tbuckley/cabot-search huggingface dataset:
Abstract LB-120: Acetylated Kruppel-like factor 5 and transforming growth factor-β mediated drug resistance in prostate cancer
Authors: Yixiang Li, Baotong Zhang, Jin-Tang Dong
Journal: Cancer Research (2019)

Abstract Purpose: In this study, we explored the role of Kruppel-like factor 5 (KLF5) and its acetylated form on lysine 369 in transforming growth factor-β (TGFβ) induced drug resistance to promote antitumor synergy and overcome drug resistance in advanced stage prostate cancer. Procedures: Two aggressive prostate cancer cell lines DU 145 and PC-3 were treated with docetaxel to measure cytotoxicity. To assess docetaxel resistance, we used in-vitro cell survival assay, colony survival assay and xenograft mouse model. In addition, TGFβ1 and SB505124 (TGFβ receptor I inhibitor) were used to explore TGFβ induced docetaxel resistance. To measure function of KLF5 and its different acetylation form on lysine 369, stable cell lines were constructed with different KLF5 acetylation status mimics after knocking out endogenous KLF5, utilizing the CRISPR-Cas9 system. Results: We found that KLF5 alone induced docetaxel resistance in vivo, but not in vitro. Moreover, endogenous knocking out of KLF5 inhibited TGFβ induced docetaxel resistance. In addition to previous findings that TGFβ recruits P300 acetyl-transferase to acetylate KLF5 on lysine 369, we further found that TGFβ induced docetaxel resistance depends on acetylation of KLF5. In addition, Mass Spectrometry analysis revealed that JUNB, a downstream target of non-canonical TGFβ pathway, is a direct binding target of acetylated KLF5 but not de-acetylated KLF5. Knocking down of JUNB in acetylated KLF5 mimic cell line inhibited TGFβ induced docetaxel resistance. Conclusions: These suggested that acetylated KLF5 is indispensable in TGFβ induced drug resistance through interaction with JUNB. Our study introduced a novel mechanism of acetylated KLF5 and JUNB mediated docetaxel resistance in prostate cancer and contributed to an advanced therapy combination for advanced prostate cancer patients. Citation Format: Yixiang Li, Baotong Zhang, Jin-Tang Dong. Acetylated Kruppel-like factor 5 and transforming growth factor-β mediated drug resistance in prostate cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr LB-120.
Stem cell transplantation in myelofibrosis
Authors: Nicolaus Kröger
Journal: HemaSphere (2018)

Department of Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg Germany This is an open access Abstract Book distributed under the Attribution-NonCommercial-NoDerivs (CCBY-NC-ND), which allows third parties to download the abstracts and share them with others as long as they credit the author and the abstract book, but they cannot change the content in any way or use them commercially. http://creativecommons.org/licenses/by-nc-nd/4.0
Is It Worth a Dam?
Authors: Stephanie Joyce
Journal: Environmental Health Perspectives (1997)

Once a sign of modernization and growth, dams are often seen today as symbols of environmental and social devastation. Over 800,000 dams have been built worldwide to provide drinking water, flood control, hydropower, irrigation, navigation, and water storage. Dams do indeed provide these things,but at the cost of several adverse, unexpected effects: disruption of ecosystems, decline of fish stocks, forced human and animal resettlements, and diseases such as malaria, which are borne by vectors that thrive in quiet waters.
Continuity of care
Authors: J. S. Gonnella
Journal: JAMA (1980)

. Continuity of care is of value only to the extent that it has an impact on the outcome of care, the prevention or reduction of physical, mental, or social disabilities, the satisfaction of patients, and the costs of care. It is important that research studies include patients with a broad range of social characteristics and that costs as well as health care benefits be measured. An accountability model describing the contributions of physicians, health care institutions, patients, and the local community to health outcomes is recommended. The following three principles are outlined for the evaluation of health care: (1) determine the patient's health status before and after care, (2) use appropriate measures of health outcomes, and (3) consider potential effects of factors extrinsic to medical care. (<i>JAMA</i>243:352-354, 1980)
The environment we live in
Authors: None The Lancet Public Health
Journal: The Lancet Public Health (2017)

The air we breathe. The water we drink. The house we live in. The environment we live in is a crucial determinant of population health. For too long neglected, dismissed, or disregarded, the importance of the environment we live in can no longer be ignored. Evidence of the impact on health of the quality of our environment is mounting. According to WHO's latest environmental burden of disease assessment, 12·6 million individuals die worldwide every year because of unhealthy environment. The Global Burden of Disease Study estimates that disease caused by all forms of pollution was responsible for 268 million disability-adjusted life years in 2015.
Empathy
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prospective, Longitudinal Assessment of Developmental Neurotoxicity
Authors: Joseph L. Jacobson, Sandra W. Jacobson
Journal: Environmental Health Perspectives (1996)

Methodological issues in the design of prospective, longitudinal studies of developmental neurotoxicity in humans are reviewed.A comprehensive assessment of potential confounding influences is important in these studies because inadequate assessment of confounders can threaten the validity of causal inferences drawn from the data.Potential confounders typically include demographic background variables, alcohol and smoking during pregnancy, the quality of parental stimulation, the child's age at test, and the examiner.Exposure to other substances is assessed where significant exposure is expected in the target population.In most studies, control variables even weakly related to outcome are included in all multivariate statistical analyses, and a toxic effect is inferred only if the effect of exposure is significant after controlling for the potential confounders.Once a neurotoxic effect has been identified, suspected mediating variables may be added to the analysis to examine underlying processes or mechanisms through which the exposure may impact on developmental outcome.Individual differences in vulnerability may be examined in terms of either an additive compensatory model or a synergistic "risk and resilience" approach.Failure to detect real effects (Type 11 error) is of particular concern in these studies because public policy considerations make it likely that negative findings will be interpreted to mean that the exposure is safe.Important sources of Type 11 error include inadequate representation of highly exposed individuals, overcontrol for confounders, and inappropriate correction for multiple comparisons.Given the high cost and complexity of prospective, longitudinal investigations, cross-sectional pilot studies focusing on highly exposed individuals can be valuable for the initial identification of salient domains of impairment.
Éléments de pharmacodynamie spéciale: Étude de l'action des divers médicaments.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
X-Ray Diagnosis: A Manual for Surgeons, Practitioners and Students.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lupus Carditis
Authors: Mary Betty Stevens
Journal: New England Journal of Medicine (1988)

The cause of the cardiac problems that develop in patients with systemic lupus erythematosus, especially those who are taking corticosteroids or are immuno-suppressed, is often a complex clinical problem. Key therapeutic decisions depend on whether the problem results from an inflammatory, immune-mediated lesion of active systemic lupus erythematosus, a subsequent complication of the disease and its therapy, or an intercurrent process (especially infection) for which the patient is at particularly high risk. Usually, the diagnosis of true lupus carditis is made by exclusion as well as by association with extracardiac features of systemic lupus erythematosus.In this issue of the . . .
INTRAUTERINE TRANSFUSION
Authors: W. D. Bowman
Journal: JAMA (1965)

The development by Liley<sup>1</sup>of a practical method of in utero treatment of the infant severely afflicted with hemolytic disease would appear to have altered profoundly the prognosis for many babies who would otherwise die of their disease before 32 weeks gestation, too early for induction of labor to hold any hope for survival. Queenan, in this issue ofThe Journal(p 943), reports the case of an infant whose life was saved by two intrauterine transfusions. Several other reports of the successful use of this procedure have appeared recently.<sup>2,3</sup> Experience in Winnipeg, where intrauterine transfusion has been practiced extensively for the past year, confirms its value but demonstrates that there are problems and difficulties involved.<sup>4</sup>To date 45 intrauterine transfusions have been given to 23 patients. In all cases the decision to transfuse was based on amniotic fluid examination,<sup>5</sup>usually at 24 to 26 weeks
Bacterial Vaginosis
Authors: Dominic Pennachio
Journal: JAMA (1986)

<h3>To the Editor.—</h3> We write with reference to the recent article by Swedberg et al<sup>1</sup>entitled "Comparison of Single-Dose vs One-Week Course of Metronidazole for Symptomatic Bacterial Vaginosis." We find it difficult to support the authors' conclusions that prolonged therapy with metronidazole is more effective than "one-dose" therapy since such a large number of subjects were unavailable for follow-up. Only 65% (64/98) completed the trial, with most of the dropouts coming from the single-dose group. It is quite likely that those unavailable for follow-up had become asymptomatic and were therefore more likely to be cured. This could well reduce or abolish the differences in outcomes between the two study groups. The exclusion of any demographic data makes it difficult to determine the applicability of the results to other practices. In addition, the small number of patients makes it impossible to draw any conclusions about the efficacy of treating sexual
Ambulatory Pediatrics
Authors: J. C. Haworth
Journal: JAMA (1968)

In no other branch of medicine has the pattern of practice changed more during the past few decades than in pediatrics. Gone are the days when children's wards were filled with patients suffering from a variety of infectious diseases, nutritional deficiency diseases, and orthopedic deformities resulting from poliomyelitis or osteomyelitis. Pediatricians are finding that they have less need to admit children to hospital, because of advances in diagnostic techniques and the availability of specific and rapidly acting drugs. Other factors responsible for the increasing use of ambulatory care include increasing costs of maintaining children in hospital, shortage of nursing staff, fear of cross infection, and concern about the psychological effects on the small child separated from his home and parents. The appearance of this book is therefore timely. It deals with every aspect of child health care outside the hospital wards—in the home, the doctor's office, the hospital out-patient department,
Foetal Cries
Authors: W. Hartston
Journal: BMJ (1947)

divisions-extractions, by which the whole varicose vein could be extirpated through incisions-rarely more than 1/4 to 1/3 in. (0.63-0.85 cm.) in length-at intervals along the vein, the sites for incision carefully selected in the standing patient and indelibly marked before operation.The incisions, Wiade parallel to the lines of tension of the skin, gape but little and do not require suLturing.Only very few ligations of severed veins are ever necessary, and perforating veins and tributaries can be divided and ligated or, if small, torn off flush with the deep fascia with- out the use of a vein enucleator.In some cases new varicose veins have appeared so soon after extirpation of the old as to raise inescapably the question of overloading in the deep veins and a new compensatory reflux through deep communicating veins, and the wisdom of severing all deep communications, if that were feasible.Here I take opportunity to record my indebtedness to Mr.
Last Impressions
Authors: Lawrence M. Linett
Journal: JAMA (1986)

I disliked him immediately. He was one of the last patients I worked up during my internship, a seemingly interminable year that was finally coming to a close. His diagnosis was inoperable lung cancer, the deadly seed of which had already blossomed in his liver and bones. He had refused chemotherapy in the past, consenting only to local radiation therapy. Concerned about his increasing confusion, hostility, and disorientation, his family had brought him that night to the emergency room for evaluation. As I approached him, I could sense his hostility. He looked older than his 72 years; the ravages of cancer were obvious in his pasty complexion and marked muscle wasting. His eyes sat deep in their sockets, and the sparse white tufts of hair on his head reminded me of dead trees on a mountain ridge. "I don't like doctors and I don't want to stay," he began. "Who
Paediatric specialist registrars' views of educational supervision and how it can be improved: a questionnaire study
Authors: B W Lloyd, D Becker
Journal: Journal of the Royal Society of Medicine (2007)

Objectives To determine what paediatric specialist registrars think of the educational supervision they have received and what advice they would give to a consultant who wanted to be a more effective educational supervisor.Design A questionnaire study.Setting The North Thames Deanery, UK.Participants 129 year 3, 4 or 5 paediatric specialist registrars in the North Thames Deanery.Main outcome measures Reported value of educational supervision on a Likert scale; what elements of educational supervision were reported to be most useful; what elements of educational supervision were reported to be done poorly; what advice would specialist registrars give to a consultant who wanted to be a more effective educational supervisor.Results 86/129 specialist registrars responded (67%).The mean score on the Likert scale (0-a complete waste of time; 100-excellent) was 57 with 37% of respondents giving a score of less than 50.The most valued aspects of educational supervision were: feedback on performance-cited by 50 respondents (56% of respondents); career advice-cited by 43 (48%); objective setting-cited by 36 (40%); pastoral support-cited by 25 (28%).Aspects of educational supervision that were reported to be often not done well were: commitment to educational supervisioncited by 44 respondents (49% of respondents); ensuring sessions are bleep-free-cited by 43 (48%); listening rather than talking-cited by 23 (26%); being encouraging-cited by 18 (20%).Advice to consultants about how to improve educational supervision included: listen rather than talk; be encouraging; treat the trainee as an individual with individual needs. ConclusionsWe can find no other study of trainees' views about how educational supervision can be improved.Although some trainees found educational supervision very valuable, many did not.Educational supervision should only be carried out by consultants who are committed to the task.An educational supervisor should listen carefully in order to understand the trainee's individual ambitions and needs, should provide specific feedback on performance and should be encouraging.
Diagnostic Errors and Patient Safety
Authors: Robert M. Wachter
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Experimental Hepatoma Conference&lt;xref ref-type="fn" rid="fn1"&gt;2&lt;/xref&gt;
Journal: JNCI Journal of the National Cancer Institute (1955)

Experimental Hepatoma Conference JNCI: Journal of the National Cancer Institute, Volume 15, Issue Supplement_5, April 1955, Page III, https://doi.org/10.1093/jnci/15.Supplement_5.III Published: 01 April 1955
The Use of Fish for Mosquito Control.
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Percutaneous mitral balloon valvotomy and the new demographics of mitral stenosis
Authors: J. D. Carroll
Journal: JAMA (1993)

<h3>Objective.</h3> —This review discusses the latest developments in selected clinical features and catheter-based therapy of mitral stenosis. <h3>Data Sources.</h3> —English-language journal articles and reviews in the clinical and epidemiological literature as related to mitral valve stenosis from 1965 through March 1993, identified by bibliography review and expert consultation. <h3>Study Selection.</h3> —Selected studies included clinical trials with adequate patient population description and short- and long-term (5 years) follow-up for topics related to mitral valve stenosis in the clinical literature. <h3>Data Extraction.</h3> —Two reviewers participated in extracting the data with the aim of presenting a balanced and comprehensive review of the subject. <h3>Data Synthesis and Conclusions.</h3> —The main conclusions are (1) mitral stenosis should no longer be viewed as a largely "geriatric disease" in the United States due to a recent inflow many young immigrants from countries where rheumatic fever continues partially or wholly unabated; (2) clinical and anatomical features of mitral stenosis are age-dependent; when clinical presentation occurs at 30 vs 70 years of age, for example, the degree of valve obstruction may be similar but differences exist in the frequency of atrial fibrillation, the magnitude of reduction in cardiac output, the degree of valve deformity and calcification, and the frequency of coexistent coronary artery disease; and (3) mitral stenosis therapy has undergone a reorientation with the introduction of percutaneous mitral balloon valvotomy, which has proven to be safe, cost-effective, and to provide short- and long-term improvements in symptomatic and hemodynamic status in selected patients. (<i>JAMA</i>. 1993;270:1731-1736)