tbuckley/cabot-search huggingface dataset:
Abstract O.19: Fine Specificity Of Natural Regulatory T Cells That Modulate Vascular Inflammation
Authors: Alessandra Franco, Ranim Touma, Robert L Padilla, Adriana H Tremoulet, John Sidney, Alessandro Sette, Jane C Burns
Journal: Circulation (2015)

Objective: We recently defined that a critical mechanism of IVIG therapy in KD patients is the activation and expansion of natural regulatory T cells (nTreg) that recognize the heavy constant region (Fc) of IgG1. Lack of circulating Fc-specific nTreg in the sub-acute phase of KD strongly correlates with arterial complications. Notably, Fc-specific nTreg are always detectable in circulation in healthy donors, suggesting their importance in maintaining vascular homeostasis. Here we aim at the characterization of the fine specificity of these nTreg by testing the immunogenicity of synthetic peptides (&gt; 97% purity) 15 amino acid long, overlapping 10 amino acids, spanning the whole Fc protein. Methods: To define the immunodominat Fc sequences for nTreg expansion, T cell lines have been established with pools of two consecutive overlapping peptides been generated from PBMC ex vivo from: 1) healthy donors, 2) sub-acute KD subjects (2 weeks after IVIG), and 3) KD subjects that received IVIG 1-2 years earlier. IL-10 secretion and CD4+ CD25high T cell expansion have been the read-outs in these experiments. Results: 14 peptides have been defined immunogenic in all the 3 cohorts with several peptides recognized by the large majority of the subject studied, including patients with arterial complication that did not respond to the whole Fc protein. The algorithm prediction of the HLA binding affinity of these nTreg peptide epitopes suggests that these immunodominant regions of the Fc protein are promiscous for HLA binding and very good candidate for future therapeutic use. Clinical relevance of the findings: Immunodominat Fc peptides are an optimized, low cost alternative to IVIG, potentially capable to overcome the lack of nTreg responses in KD patients that develop arterial complications.
Double-Blind Trial of Carisoprodol
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
What the educators are saying
Authors: Lambert Schuwirth, Peter Cantillon
Journal: BMJ (2004)

What the educators are saying Identifying poorly performing junior doctorsBeing able to identify poorly performing doctors early in their careers is an attractive idea.A recent qualitative study describes the development of a 360°appraisal tool for use in the intern (preregistration house officer) year.Focus group data identified 51 critical behaviours grouped under eight dimensions: clinical skills, practical skills, patient investigation, patient management, communication, decision making, teamwork, and professionalism.Appraisers can be the educational supervisor, specialist registrars, fellows, senior house officers, and nurses.The tool now needs to be validated.
<i>Disease of the Mid-brain Region, with Special Reference to Ophthalmoplegia, and a Note on Post-hemiplegic Ataxia.</i>By B. Sachs. M. D., Professor of Mental and Nervous Diseases in the New York Polyclinic. From the<i>American Journal of the Medical Sciences,</i>March, 1891
Journal: American Journal of Psychiatry (1891)
BUDAPEST
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Active Immunization
Authors: Geoffrey Edsall
Journal: New England Journal of Medicine (1949)

Tetanus Effectiveness of Toxoid The results of tetanus-toxoid immunization in the United States Army in World War II have been presented in illuminating detail by Long and Sartwell,310 whose paper has been abstracted in extenso in the Journal.311 Long8 has also presented a brief summary of this material. The remarkable results obtained in the United States Army have been so well publicized that it will suffice to present here only the essential facts. The procedure employed was to administer three doses of 1 cc. each, at intervals of three to four weeks, followed by a single stimulating dose of . . .
PTH-014 Does flexible sigmoidoscopy increase the polyp and cancer detection yield when used to supplement CT colonography?
Authors: C P Selinger, J Mullender, S Choudhury, P E Jones, S Sukumar, J Ramesh
Journal: Gut (2010)

<h3>Introduction</h3> Flexible sigmoidoscopy (FS) increases the polyp and carcinoma detection yield when used as an addition to double contrast Barium enema.1 The addition of FS to Barium enema has therefore been advised as standard practice.2 CT colonography (CTC) has replaced Barium enemas in many hospitals. We aim to explore whether FS increases the polyp and carcinoma detection yield when used as an addition to CTC. <h3>Methods</h3> Using endoscopy and radiology databases patients who underwent both FS and CTC between 2007 and 2009 were identified. Data were collected from those databases and the electronic patient records. Analysis was based on performed tests regardless of quality of bowel prep (FS and CTC), ability to retain gas (FS and CTC) or extent of procedure (FS). Yields of polyp, adenoma and carcinoma detection were calculated. Serious pathology was defined as cancers and adenomas &gt;9 mm. <h3>Results</h3> A total of 294 patients (179 female; 60.8%), with a mean age of 67 years were included. CTC detected 36 patients with carcinomas while FS detected 26. One rectal cancer not seen on CTC was diagnosed by FS. Polyps were seen by CTC in 71 and by FS in 47 patients. In five patients FS found polyps that were not detected by CTC, 3 of which were small (5 mm) adenomas. FS detected extra adenomas or carcinomas in four of 294 cases, producing a yield of 1.36%. The number needed to endoscope to detect one extra adenoma was 74. Serious additional pathology was detected by FS in a single case, producing a yield of 0.34%. The number needed to endoscope to detect one extra serious pathological finding was 294. <h3>Conclusion</h3> FS has a low yield of adenomas when used as an additive to CTC. The yield for serious pathology was very small in our series. Based on these findings the usefulness of routine use of FS as a supplement to CTC for adenoma and carcinoma detection is questionable. FS can however provide valuable additional information about inflammation, infection or vascular lesions depending on indication.
A Model for the Release of Adsorbed Molecules from the Surfaces of Airborne Particulate Matter Based on Liquid-Phase Desorption from Amorphous Carbon Blacks
Authors: Terence H. Risby, Shelley S. Sehnert, Long Jiang, Bhim S. Dhingra
Journal: Environmental Health Perspectives (1988)

The release of molecules adsorbed on the surfaces of amorphous carbon blacks has been studied using liquid-solid chromatography. Adsorbate molecules, adsorbents, and mobile phases were selected on the basis of their relevance as models for the release of toxic agents adsorbed on inhalable environmental particulate matter that originates from the incomplete combustion of organic materials. The presence of surface active groups on the carbon blacks has been shown to adsorb and retain adsorbate molecules selectively, and this selectivity can be reduced by competition for these active groups by the displacing solvent. Release is also governed by the surface coverage of the particles and increases as coverage approaches the monolayer.
Maternal and foetal outcomes, biochemistry and immunology changes during pregnancy in patients with autoimmune hepatitis
Authors: Kathryn Olsen, James Hodson, Vincenzo Ronca, Jennifer Hayden, Grace Wootton, Ellen Knox, Omar El-Sherif, Matthew Armstrong, Tracey Johnston, James Ferguson, Fiona Thompson, David Adams, Ye Oo
Journal: Journal of Hepatology (2020)
Medical Paris of To - Day: Notes Made in December, 1888
Authors: E. Hart
Journal: BMJ (1889)

Hardy's Treatment of the Itch.IF it is to the SalpftriKre that the student of neuropathology-the curious rare forms of hypnotism and hysteria major-and the connoisseurs of diagnostic acumen and highly developed clinical teaching will first direct their steps, it is, on the other hand, to the H8pital St. Louis, situated in an opposite quarter of Paris, that the devotee of dermatology and the student of syphilography will make his first visit.He finds there a great mass of material, a developed system of examination and teaching, special museums and methods of treatment, many of whieh have originated on the spot, and are applied with precision and success.
PHYSICAL FITNESS
Journal: JAMA (1961)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Repetitive Publication
Authors: DONALD S. COFFEY
Journal: Annals of Internal Medicine (1987)

Letters and Corrections1 October 1987Repetitive PublicationDONALD S. COFFEY, Ph.D.DONALD S. COFFEY, Ph.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-107-4-603_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The recent editorial comment on repetitive publication (1) addresses the important issue of duplication of published data; but the spirit in which the editorial was written and the example chosen were unfortunate. As presented, the editorial misled readers in a far more biased way than does the situation that the editorial addresses. The specific case of duplicate publication cited in the editorial was not as simple as it was made to appear.In reviewing this situation, I found that the authors presented the original manuscript toAnnalsfor peer review and it was accepted for publication (2)....References1. HUTH E. Repetitive publication: a clinical trial of norfloxacin. Ann Intern Med. 1987;106:906. LinkGoogle Scholar2. KARPMERZHENDRICKSEN JWC. Oral norfloxacin for prevention of gram-negative bacterial infections in patients with acute leukemia and granulocytopenia: a randomized, double-blind, placebo-controlled trial. Ann Intern Med. 1987;106:1-7. LinkGoogle Scholar3. KARPMERZHENDRICKSEN JWC. Infection management during antileukemia treatment-induced granulocytopenia: the role for oral norfloxacin prophylaxis against infections arising from the gastrointestinal tract. Scand J Infect Dis. 1986;48(supp):66-78. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: The Johns Hopkins Oncology Office Baltimore, MD 21205 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAuthor's ReplyEditor's Reply 1 October 1987Volume 107, Issue 4Page: 603-604KeywordsPeer review Issue Published: 1 October 1987 PDF downloadLoading ...
Isoenzymes of Serum Alkaline Phosphatase in Hepatobiliary and Skeletal Disease
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 2866: Surfaceome profiling in osteosarcoma: Identification of the candidate immunotherapeutic target
Authors: Yifei Wang, Zhongting Zhang, Sankaranarayanan Kannan, Wendong Zhang, Michael Roth, Jonathan B. Gill, Zhaohui Xu, Xiangjun Tian, Jing Wang, Richard Gorlick
Journal: Cancer Research (2019)

Abstract Osteosarcoma (OS) is the most common primary malignant bone tumor in pediatric patients. Current developments in targeted therapeutic strategies show potential clinical implications in cancer treatments. However, immunotherapies such as antibody-drug conjugates (ADCs) or CAR-T cell therapy have not been sufficiently studied in OS because of the lack of tumor-specific target. In this study, we developed a multi-step RNA-seq based pipeline. First, we did RNA sequencing for our OS PDX models and 17 patient-derived OS cell lines. The results are then pooled with the RNQ-seq data from 111 OS patient via the Therapeutically Applicable Research to Generate Effective Treatments project (TARGET). All these tumor data are subsequently compared with normal tissue RNA-sequencing data from NIH Genotype-Tissue Expression (GTEx) database. The significantly differentially expressed genes (log fold change tumor versus normal &amp;gt;1 for each tissue, p &amp;lt; 0.01) are selected. We further filtered this gene list by cell surface protein prediction based on Gene Ontology, the TransMembrane prediction using hidden Markov models (TMHMM), and glycosylphosphatidylinositol (GPI)-anchored protein annotations. Based on the transcriptomic result, ranks of differentially expressed genes were generated. CD276, LCLAT1, and OR8B12 are the surface markers with high ranks. To validate the transcriptomic results, we prepared surface protein extraction of the PDX models and patient-derived OS cell lines. We are profiling these surface proteins by proteomic mass spectrometry. Further validation for the expression level and location of these markers are underway. Our current finding is not previously reported in OS. The results warrant further development of ADC and car-T cell therapy. Note: This abstract was not presented at the meeting. Citation Format: Yifei Wang, Zhongting Zhang, Sankaranarayanan Kannan, Wendong Zhang, Michael Roth, Jonathan B. Gill, Zhaohui Xu, Xiangjun Tian, Jing Wang, Richard Gorlick. Surfaceome profiling in osteosarcoma: Identification of the candidate immunotherapeutic target [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2866.
Hypoplastic Anemia
Authors: Mario Stefanini
Journal: JAMA (1961)

<h3>To the Editor:—</h3> A 19-year-old Canadian worker who had been exposed to paints and solvents for at least a year showed marked pallor and hemosiderotic tinge. The liver was felt 2 fingerbreadths below the costal margin; the spleen was not palpable. Blood tests showed the following findings: hemoglobin level, 5 Gm.%; red blood cell count, 1,770,000 per cubic millimeter; white blood cell count, 1,250, with 2% band forms, 21% neutrophils, and 77% lymphocytes; and platelets, 45,000 per cubic millimeter ( measured by the direct method ). Repeated bonemarrow aspirations and one surgical biopsy specimen showed severely hypoplastic bone marrow. The serum iron level was 227 mcg.%. The serum contained agglutinins against homologous white cells and platelets at a titer of 1/32 and 1/128 respectively. There were no incomplete or coating antibodies against homologous red cells. The patient had received at least 200 transfusions over the past three years. One hundred mg. of
TO PREVENT ADULTERATED DRUGS.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Thermal Modification of Chrysotile Asbestos: Evidence for Decreased Cytotoxicity
Authors: R. Valentine, M. J. W. Chang, R. W. Hart, G. L. Finch, G. L. Fisher
Journal: Environmental Health Perspectives (1983)

Many asbestiform minerals exhibit temperature-dependent thermoluminescence. Since thermoluminescence involves electronic transitions within crystalline materials, the effect of temperature on asbestos cytotoxicity was evaluated. Heat pretreatment of Canadian chrysotile asbestos reduces its cytotoxicity towards cultured human fibroblasts and bovine alveolar macrophages. When monitored 44 hr after the addition of either 200 degrees C or 400 degrees C heat-pretreated asbestos, alveolar macrophage viability was approximately 40% higher than comparable amounts of unheated asbestos. Similarly, asbestos toxicity, expressed as fibroblast growth inhibition, was inversely related to the asbestos pretreatment temperature in the following manner, 70 degrees C greater than 200 degrees C greater than 400 degrees C = unexposed fibroblast controls. Pretreatment of chrysotile asbestos to 400 degrees C reduced its adsorptive capacity for bovine serum albumin by 25%. Furthermore, asbestos heated to 200 degrees C followed by irradiation with 4 MeV X-rays (4500 rads) resulted in reactivation of asbestos cytotoxicity. Scanning electron microscopy indicated that the ratios of free to fiber-associated alveolar macrophages and the fiber fragment size distributions were unaffected by either heat pretreatment or X-ray irradiation. These observations strongly suggest that the surface charge characteristics and electronic state of asbestos fibers may be responsible for its biological activity.
Correction: Effects of oral propranolol on parathyroid hormone secretion in chronic renal failure
Journal: BMJ (1980)

lymphocytes, polymorphonuclear leucocytes, plasma cells, and occasional eosinophils.The cortical infiltrations were often around the glomerular vascular pole and one or two aggregations of macrophages were noted in the adventitia of small interlobular arteries.Early diffuse diabetic glomerulosclerosis was present.Immunofluorescence to IgG, IgA, fibrin, and C3 was found in glomerular capillary walls and mesangial regions.The appearances suggested that a granulomatous arteritis was developing in addition to interstitial nephritis.Clofibrate was discontinued and the rash faded over two days.The urine output was always greater than 800 ml/24 h, but despite appropriate fluid, electrolyte, and insulin treatment the blood urea concentration rose over five days to 56 mmol/l (337 mg/100 ml).It then fell, without dialysis, to 6-5 mmol/l (39 mg/100 ml) nine days later, with a daily diuresis of 5-7 1.Three weeks after admission creatinine clearance was 85 ml/min and the urine was protein free.