tbuckley/cabot-search huggingface dataset:
Incorrect Values in Flow Diagram
Authors: Dhruv Khullar, Daniel Wolfson, Lawrence Casalino, Casalino Khullar
Journal: JAMA (2019)

have the support and freedom to address the challengesfragmented care, behavioral health problems, and unstable housing-with which the authors are concerned.Our Viewpoint highlighted several programs that illustrate this point.Medicare's Comprehensive Primary Care Plus program provides practices with up-front payments and technical assistance to learn about and meet the needs of complex patients, coordinate care with other practitioners, and share best practices.The process for selecting quality metrics at Providence St Joseph Health emphasizes identifying measures that patients care most about.Team-based reward systems, such as the system used at Geisinger Health System to reduce hemoglobin A 1c levels for diabetic patients, encourage collaboration across disciplines to improve care, whether that means educating patients with low health literacy or integrating behavioral health services for patients with comorbid psychiatric disease.It is important to specify when patient-related behaviors and social circumstances are important for health system performance and when they are not.A focus on social determinants of health-stable housing, poverty, and neighborhood violence-is critical for some populations, but surely less so for others.Professionalism, however, is vital in both contexts.Moreover, many measures of quality with profound effects on morbidity and mortality do not rely on patient-centered metrics.No amount of transportation vouchers will prevent a central line infection.Also, even in cases in which patient-related social factors are important, professionalism plays a central role.The authors close with a reasonable call for metrics that focus on patient engagement, social determinants of health, and health literacy.Realizing each of these worthwhile goals does not require softening talk of professionalism but, rather, promoting it.Consider an older, Spanish-speaking patient with multiple comorbidities and worsening diabetes for whom a physician is initiating insulin therapy.Patient-centered metrics might include ensuring that the patient is given medication instructions in Spanish and screened for stable housing with a refrigerator.But ensuring that this patient has a positive outcome requires much more, including spending extra time to ensure the patient understands the regimen with the assistance of an interpreter; discussing the case with the practice's nurse practitioner, dietician, and care manager; alerting the patient's cardiologist and neurologist to the medication change; and engaging family members to help with the patient's care.Far from distracting from patient-centered care, professionalism defines it more so than any paycheck, checklist, or check box.
Course of Clinical Lectures on Surgical Diseases: Delivered at the Hospital of La Charite'
Authors: None Velpeau
Journal: BMJ (1841)

I SHALL continue, gentlemen, my series of cases, illustrative of this affection. CASE III.-Excision of the second metatarsal bane-purulent infiltrationt of the foot-jaundice- death on the 1oth day-pus in all the veins and in the heart-numerous metastatic abscesses in other organs.-HENRICUS, nineteen years of age, about siY
Commentary
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical Connections
Journal: Arthritis & Rheumatology (2018)

Toll-like receptor 7 (TLR-7) and TLR-9 are innate pathogen-recognition receptors for single-stranded RNA and double-stranded DNA (dsDNA), respectively.They are important for host defense against viruses and bacteria; however, in systemic lupus erythematosus, self-reactive anti-RNA and anti-dsDNA autoantibody-containing immune complexes (ICs) can act as their ligands.Evidence supports a role for TLR-7 in the initial loss of selftolerance and increased expression resulting in severe disease.In contrast, despite similar signaling pathways, elimination of TLR-9 across murine models results in aggressive lupus nephritis.This is due to the protective effect of TLR-9 on excessive antibody switching to IgG and RNA specificity and the regulation of TLR-7 expression.As reported in the study by Celhar et al, in the absence of TLR-9, both the TLR-7 protein and its ligands are increased, leading essentially to a TLR-7-driven autoimmune disease phenotype. KEY POINTS• Severe disease in TLR-9 -/-Sle1 mice is associated with increased TLR-7 protein expression.• Increased TLR-7 in renal dendritic cells (DCs) precedes disease, implying their causative role.• TLR-9 deficiency drives B cell antibody specificity toward RNA-associated antigens.• Increased TLR-7-reactive ICs and TLR-7 protein combine to drive severe disease in murine lupus models.
Highlights From the <i>Circulation</i> Family of Journals
Journal: Circulation (2018)

There are limited data on predictors of long-term clinical outcomes after catheter ablation of atrial fibrillation.This secondary analysis of 750 participants enrolled in the FIRE AND ICE trial assesses the association of baseline covariates with clinical outcomes in drug-refractory paroxysmal atrial fibrillation.The study found that women had a ≈40% higher risk than men of recurrence of atrial arrhythmia and cardiovascular rehospitalization after catheter ablation of atrial fibrillation.
THE PHYSICIAN'S RESPONSIBILITY: AN IMPORTANT DECISION ON PROFESSIONAL SECRECY
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effectiveness of dupilumab treatment in 95 patients with atopic dermatitis: daily practice data
Authors: L.E.M. Wijs, A.L. Bosma, N.S. Erler, L.M. Hollestein, L.A.A. Gerbens, M.A. Middelkamp‐Hup, A.C.M. Kunkeler, T.E.C. Nijsten, P.I. Spuls, D.J. Hijnen
Journal: British Journal of Dermatology (2020)

Atopic dermatitis (AD) is a type of eczema that is very common in children, but also affects 2‐10% of all adults worldwide. The main symptom is itch, which can be severe enough to stop the person sleeping properly. It can be found on any part of the skin, including the face, but the areas that are most commonly affected are the elbows, knees, wrists and neck. The skin is usually red and dry and may bleed from scratching.
Medical Discipline
Authors: Bruce E. Vodicka
Journal: JAMA (1975)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medical News
Journal: JAMA (1907)

<h3>ALABAMA.</h3><h3>Money for Medical Department.</h3> —The lower branch of the legislature on February 20 passed a bill appropriating $1,673,000 to further the interests of education. Of this the Medical College of Alabama, Mobile, is to receive $65,000. <h3>ARIZONA.</h3><h3>Personal.</h3> —Dr. Charles H. Jones, Tempe, has been seriously ill with influenza.—Dr. Charles F. Hawley, Mesa, has removed to Bisbee.—Dr. D. D. Whedon, Tucson, has been appointed physician of Pima County. <h3>Election.</h3> —At a meeting of the Cochise County Medical Society, held at Bisbee, March 2, the following officers were elected: President, Dr. Fenn J. Hart, Bisbee; vice-presidents, Drs. Charles L. Caven, Bisbee, John E. Bacon, Tombstone, and James J. P. Armstrong, Douglas; secretary-treasurer, Dr. Edward S. Godfrey, Jr., Lowell, and censor, Dr. George A. Bridge, Bisbee. <h3>ARKANSAS.</h3><h3>Do Not Want Names Published.</h3> —At a recent meeting of the Jefferson County Medical Society, the members of the society were urged to refrain
Medical School Faculties and Educational Programs
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
&lt;TITLE&gt;Participating in Medical Research Studies&lt;/TITLE&gt;
Journal: JAMA (2001)

When we hear news of the results of new medical research, we often do not think of the individuals who participated in the study.Whether it is a study about a particular treatment, a survey about the health conditions people experience, or a study that measures sleep patterns, researchers depend on individuals like you and those who are willing to volunteer to be part of these potentially important studies.The February 7, 2001, issue of JAMA is dedicated to articles about opportunities for medical research.
Risk of Cancer in an Occupationally Exposed Cohort with Increased Level of Chromosomal Aberrations
Authors: Zdenek Smerhovsky, Karel Landa, Pavel Rossner, Marek Brabec, Zdena Zudova, Nora Hola, Zdena Pokorna, Julie Mareckova, Dana Hurychova
Journal: Environmental Health Perspectives (2001)

We used cytogenetic analysis to carry out a cohort study in which the major objective was to test the association between frequency of chromosomal aberrations and subsequent risk of cancer. In spite of the extensive use of the cytogenetic analysis of human peripheral blood lymphocytes in biomonitoring of exposure to various mutagens and carcinogens on an ecologic level, the long-term effects of an increased frequency of chromosomal aberrations in individuals are still uncertain. Few epidemiologic studies have addressed this issue, and a moderate risk of cancer in individuals with an elevated frequency of chromosomal aberrations has been observed. In the present study, we analyzed data on 8,962 cytogenetic tests and 3,973 subjects. We found a significant and strong association between the frequency of chromosomal aberrations and cancer incidence in a group of miners exposed to radon, where a 1% increase in frequency of chromosomal aberrations was followed by a 64% increase in risk of cancer (p < 0.000). In contrast, the collected data are inadequate for a critical evaluation of the association with exposure to other chemicals.
ERROR IN REPORTING PATERSON (N. J.) MORTALITY FROM TYPHOID FEVER
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Familial fatal varicella
Authors: E. B. Hook
Journal: JAMA (1968)

Five children in a family contracted chickenpox during a two-week interval and two died. Clinical observations suggested that both fatalities were due to chickenpox pneumonia and this was confirmed by necropsy study of one patient. In addition, a clinical pattern compatible with varicella pneumonia developed in another sibling who survived. The other two experienced benign illnesses. The children were between the ages of 2 and 10 years. The deaths occurred in a 9-year-old boy and a 6-year-old girl. All children in the family were in good health prior to the varicella-zoster viral infection with the exception of recent intrafamilial rubella. Study of the parents and surviving children failed to reveal an obvious immunologic deficit.
Organizations
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TCT-597 Three Year Clinical Outcomes of a Unique Sirolimus-Eluting Stent with Fully Absorbable Polymer Coating: Long-term Results from the DESSOLVE I and the DESSOLVE II Clinical Trials
Authors: John A. Ormiston, Alexandra Lansky, Dennis Donohoe, Charlene Knape, Mathias Vrolix, Stefan Verheye, Danny F. Schoors, William C. Wijns
Journal: Journal of the American College of Cardiology (2014)
Highlights
Journal: JAMA (2016)

Eff ect of Pritelivir vs Valacyclovir on Genital HSV Shedding 2495Current therapy for herpes simplex virus 2 (HSV-2) infection relies on nucleoside analogues, such as valacyclovir, which incompletely inhibit genital viral shedding.In a randomized, crossover clinical trial that enrolled 91 adults with recurrent genital herpes, Wald and colleagues assessed the effi cacy of pritelivir-a novel HSV inhibitor-compared with valacyclovir to suppress genital HSV-2 shedding during a 28-day treatment period with each drug.The authors report that compared with valacyclovir, use of pritelivir resulted in a lower percentage of genital swabs with HSV detected over the 28-day treatment period.
Calcium measurements in hyperparathyroidism
Authors: H. F. Loken
Journal: JAMA (1973)

Since McLean and Hastings<sup>1</sup>presented their classical works in the mid-thirties giving strong evidence that the ionized calcium in the biologically active fraction of the total serum calcium concentration, investigation has proceeded along two lines, one with the objective of establishing the physicochemical conditions determining the binding of calcium to serum proteins, the other trying to relate the biologically active fraction of ionized calcium to various states of disease. The biochemical research has so far enjoyed considerably greater success than the clinical. It has been shown by several subsequent scientists that the relation between ionized and protein-bound calcium is governed by physical and chemical influences, the most important being concentrations of protein and calcium, temperature, pH, and ionic strength. A third and minor fraction, consisting of calcium complexes to organic anions, is usually quite constant, but has not been as thoroughly investigated as the ionized calcium. When the factors
Excess Dosing of Antiplatelet and Antithrombin Agents in the Treatment of Non–ST-Segment Elevation Acute Coronary Syndromes—Correction
Authors: Elena Chiappini, Luisa Galli, Clara Gabiano, Pier-Angelo Tovo, Maurizio De Martino
Journal: JAMA (2006)

Limitations of our study include that, as a cohort study, there is a potential that unmeasured confounders caused the observed differences.Small sample size and few outcomes in some of the subgroups also limit the ability to reach definitive conclusions and may account for some of the differences in results compared with Berk et al. 1 As a post hoc analysis, the findings should be considered hypothesis generating.Given these factors, there is a need for randomized trials of treatment for perinatal HIV infection to understand the optimal methods of preventing disease progression.Consideration must also be given to treatment in countries where triple therapy is not available.
Clinton tinkers with health system status quo; critics seek to pick apart managed competition
Authors: P. Cotton
Journal: JAMA (1993)

THE CLINTON administration is doing more listening than talking about how to overhaul the nation's health care system, and so far is only tinkering with the status quo. Still, President William J. Clinton has promised to have a plan for universal access and cost control to Congress by May. The President took a fire-and-brimstone tone in his State of the Union address when running through the litany of health care system horrors and how they must be solved to turn the nation's economy around. However, he offered no specifics of his overall reform plan in the hour-long speech. The President's economic package calls for $26 billion more over the next 4 years in public health spending, including expansion of childhood immunization, acquired immunodeficiency syndrome (AIDS) prevention, substance abuse prevention and treatment, and women's health research. <h3>'No New Cuts'</h3> Clinton said there would be "no new cuts" in the Medicare program