tbuckley/cabot-search huggingface dataset:
In Reply
Authors: Kenneth Offit, Kelly Kohut, Donna Bernstein, Shelly Cummings, Melody White, Michal Sagi, Jessica G. Davis
Journal: Journal of Clinical Oncology (2007)

As stated in our article, we agree that preimplantation genetic diagnosis for common cancer syndromes "has not been incorporated into common practice," 1 and will not be appropriate in some cases for psychological or other personal reasons.However, increasing physician awareness of assisted reproductive technologies (ART) is not synonymous with imposing discussion of these options on every individual.Without communicating availability of these options to reproductive-age patients, how can they make truly informed decisions?For example, such discussions will come up in the setting of patients of reproductive age with newly diagnosed cancer who may consider ART for fertility preservation, or infertile individuals with cancer predisposing mutations who seek to utilize in vitro fertilization to achieve pregnancy.Oncologists can recognize those instances when ART may be of potential interest to a couple at risk for hereditary cancer, and then make referrals to professionals who can reliably discuss reproductive options with sensitivity to the emotional aspects and ethical issues.In an effort to guide clinicians and policy makers as they attempt to distinguish circumstances for which discussions of preimplantation genetic diagnosis may be appropriate for families affected by cancer, we have recently provided an analytic framework. 2This framework takes into consideration: the age at onset of the disorder, the penetrance of the syndrome, the severity of the syndrome, the means available to decrease genetically acquired cancer risk, the availability of assisted reproduction options and the potential risks of preimplantation genetic diagnosis itself (eg, exposure to exogenous hormones).A broader discussion of the medical aspects, as well as ethical challenges of assisted reproduction will ensure its most responsible transition to clinical practice.
Importance of Radiotherapy in the Outcome of Patients With Primary CNS Lymphoma: An Analysis of the CHOD/BVAM Regimen Followed by Two Different Radiotherapy Treatments
Authors: E. M. Bessell, A. López-Guillermo, S. Villá, E. Verger, B. Nomdedeu, J. Petit, P. Byrne, E. Montserrat, F. Graus
Journal: Journal of Clinical Oncology (2002)

PURPOSE: To assess the effect of a reduced dose of radiotherapy (RT) in patients with primary CNS lymphoma (PCNSL) responding to the cyclophosphamide, doxorubicin, vincristine, and dexamethasone (CHOD)/carmustine, vincristine, methotrexate, and cytarabine (BVAM) regimen. PATIENTS AND METHODS: Patients received one cycle of CHOD and two of BVAM. In the first trial, all 31 patients received 45-Gy whole-brain RT (CHOD/BVAM I). In the second, with 26 patients, RT dose was reduced to 30.6 Gy if there was a complete response (CR) after chemotherapy (CHOD/BVAM II). RESULTS: Age, performance status, and chemotherapy received were similar in both protocols. CR rate at the end of all treatment was 68% for CHOD/BVAM I and 77% and for CHOD/BVAM II. Treatment modality was the only predictor of relapse, with 3-year relapse risks of 29% and 70% for CHOD/BVAM I and II, respectively. This was specifically important in the 25 patients less than 60 years old (3-year relapse risk, 25% v 83%; P = .01). The 5-year overall survival (OS) was 36%. Age (&lt; 60 v ≥ 60 years) was the only predictor for OS in the multivariate analysis (relative risk, 2.1; 95% confidence interval, 1.4 to 2.8). RT dose was the only predictor of OS in patients younger than 60 years old who achieved CR at the end of all treatment (3-year OS, 92% v 60% for patients receiving 45 or 30.6 Gy, respectively; P = .04). CONCLUSION: Reduction of the RT dose from 45 Gy to 30.6 Gy in patients younger than 60 years old with PCNSL who achieved CR resulted in an increased risk of relapse and lower OS.
Triiodothyronine thyrotoxicosis
Authors: S. Vaisrub
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Alien Doctors
Authors: M. Tannenbaum
Journal: BMJ (1945)

OBJECTIVE: to determine if bedside interpretation of quantative EEG analysis by non-clinical neurophysiologist is reliable for detection of seizures and changes in amplitude/frequency of EEG background. BACKGROUND: There are increasing numbers of continuous EEG being performed in the ICU setting. Rapid and real time interpretation of this data is becoming increasingly labor intensive. Availability of digital quantitative EEG analysis and display is being relied upon more frequently to recognize neurophysiological changes, and this is being used more often by non-neurophysiology trained personnel. DESIGN/METHODS: We did a retrospective review of 1000 prolonged EEGs performed between Jan 2012-Sept 2013. The reports generated after revieweing the raw data by Neurophysiologist was compared to the report of the QEEG analysis. The interpretations were compared and analyzed to obtain a false negative ratio[FNR] as well as positive predictive value[PPV] of QEEG. RESULTS: Preliminary data suggests that QEEG was as reliable as interpretation by neurophysiologist for identification of changes in amplitude/ frequency of large hemispheric lesions. However, FNR was high for seizure detection. CONCLUSIONS: While QEEG is useful as a preliminary bedside review tool for identifying asymmetries in terms of hemispheric suppression, review of raw data by trained neurophysiologist still has better PPV for seizure detection. <b>Disclosure:</b> Dr. Ozbalik has nothing to disclose. Dr. Gonzalez-Montoya has nothing to disclose. Dr. Gowda has nothing to disclose. Dr. Morton has nothing to disclose.
How About Your Kidneys, Doctor?
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Association News
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
FORCED SPINAL DRAINAGE IN ACUTE POLIOMYELITIS
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THU0138 The acute phase response does not fully explain dyslipidemia and insulin resistance in inflammatory arthritis
Authors: PH Dessein, BI Joffe, AE Stanwix, Z Moomal
Journal: Annals of the Rheumatic Diseases (2001)

<h3>Background</h3> An increased frequency of insulin resistance (IR) and dyslipidemia has been identified in inflammatory arthritis (IA). These metabolic disturbances may be attributable to disease activity and were implicated in the excess cardiovascular disease mortality as reported in IA. <h3>Objectives</h3> In the present study we evaluated insulin sensitivity and lipid metabolism, as well as the potential role of the acute phase response as a predictor of these metabolic disturbances in IA. <h3>Methods</h3> Eighty seven patients (38 rheumatoid arthritis, 29 spondyloarthropathy, 20 undifferentiated inflammatory arthritis) and 30 age-, gender- and race matched healthy controls (CN) were enrolled. Patients who had taken glucocorticoids during the previous 2 months or were taking agents known to affect insulin sensitivity or lipid metabolism were excluded. The body mass index (kg/m<sup>2</sup>) was calculated in each subject. The erythrocyte sedimentation rate (ESR), plasma glucose, serum insulin and total cholesterol (chol), LDL-chol, HDL-chol and triglycerides were determined on fasting blood samples. IR was estimated by the homeostasis model assessment (HOMA). Results were expressed as mean (SD). <h3>Results</h3> The BMI was 26.5 (4.2) in the patients and 22.9 (2.8) in the CN (p &lt; 0.001). The HOMA (uU.mmol/ml.l) was 1.9 (1.3) in patients as compared to 1.1 (0.5) in CN (p = 0.001). The HDL-chol was lower (p = 0.002) and the total chol/HDL-chol was higher (p &lt; 0.001) in patients as compared to CN. Only after controlling for the BMI in addition to the ESR, was the HOMA no longer different between patients and CN. The ESR and HOMA, but not the BMI, significantly predicted (p &lt; 0.05) high chol/HDL-chol ratios. However, after controlling for these variables, this lipid parameter remained different in patients as compared to CN. Also, IA was associated with a positive family history for premature coronary artery disease (p &lt; 0.03). <h3>Conclusion</h3> Metabolic disturbances were identified in the majority of our patients and should therefore be addressed in the management of IA. IR could be attributed to the acute phase response and excess weight. However, dyslipidemia was associated with IA independent of the ESR, BMI and IR. Dyslipidemia may constitute a risk factor for IA. <h3>References</h3> Svenson KL, <i>et al</i>. Metabolism 1988;37:125–30 Park YB, <i>et al</i>. J Rheumatol. 1999;26:1701–4 Dessein PH, <i>et al</i>. Rheumatology 2001, in press
Trauma
Authors: M. J. Ruiz-Lopez, A. Serrano-Gonzalez, A. Ruíz-Beltran, J. Garcia-Perez, J. Casado-Flores, R. B. Carrington da Costa, J. Pimentel, A. Rebelo, J. J. Costa, J. P. A. Sousa, V. Femandes, A. Simões, C. Robalo-Cordeiro, L. Mesqulta, R. Azevedo Berrarda, L. Beretta, G. Citerio, A. Dell’Acqua, L. Napolitano, C. Frascoli, M. Cenzato, N. Anzalone, C. Charpentier, G. Audibert, J. Garric, P. Welfringer, M. C. Laxenaire, G. Vazquez Mata, A. Perez Aragon, R. Rivera Fernandez, P. Navarrete Navarro, E. Fernandez Mondejar, F. Ruiz Ferrón, J. Barth, G. Hochhaus, H. W. Möllmann, F. Schumann, U. Bötel, E. v. Winden, H. Derendorf, P. Velasco, C. Domingo, R. Rincón, R. Tomás, J. Esquirol, S. Armengol, J. Gener, Ž. Djordjević, V. Antunović, B. Nestorović, B. Djurović, I. Jovanović, R. Talvik, N. O’Konnel-Bronina, Zhou Huping, Hou Zhongmin, A. Quesada, J. L. Teja, J. Serrano, J. M. Rabanal, F. L. Espadas, S. G. Herrera, G. D. Regañon, C. Garrido, B. Kremžar, A. Špec-Marn, H. Burja, L. Toš, P. Ciaglia, J. Barron, K. Graniero, W. Marx, D. D. Tran, M. A. Cuesta, P. A. M. van Leeuwen, R. I. C. Wesdorp, P. Mavrocordatos, R. Chiolero, J. -P. Revelly, C. Cayeux, J. -J. Livio, B. Bui-Xuan, None Godard, C. Guillaume, J. M. Vedrinne, P. Bachmann, B. Allaouchiche, M. E. Reverdy
Journal: Intensive Care Medicine (1992)
New concept in university community mental health services
Authors: P. Mechanick
Journal: JAMA (1969)

A group of medical students under faculty supervision has developed an experimental advisory service to assist troubled college students who are reluctant to seek formal psychiatric care because of fears of its "stigma," suspicion of university administration, and/or a belief that older professional personnel cannot understand the problems of their generation. A medical student advisor has unique positive attributes of clinical training and experience, yet is of peer age. Walk-in centers ("Talking Points"), located at strategic areas on campus, are manned during key hours. Complete anonymity of contacts is guaranteed. Psychiatric staff members hold regular supervisory sessions to review cases. In the first 14 weeks of operation, 71 clients (1% of the undergraduate population) were seen. Problems have included depression, social maladjustment, incipient psychosis, fear of pregnancy, and suicidal attempts. Clients requiring professional care are referred.
THE UNRULY PRESS.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Analgesic use, agranulocytosis, and aplastic anemia
Journal: JAMA (1987)

<h3>To the Editor.—</h3> I read with great interest the results of the International Agranulocytosis and Aplastic Anemia study.<sup>1</sup>This article gives rise, however, to some fundamental questions. First, was the method of calculation used appropriate to the study of a disease (agranulocytosis) that is largely drug induced? Second, what is the real meaning of the rate ratio estimate? Usually, a case-control study is concerned with a naturally occurring disease. The risk to the users of a particular drug is estimated by comparing the ratio of users and nonusers of the drug among cases (a/b) and controls (c/d). However, when patients with systemic diseases that can cause neutropenia are excluded, as was done in this study, the remaining cases of agranulocytosis are largely due to drugs.<sup>2</sup>If we focus on a particular drug, say X, then group b can be subdivided into patients with agranulocytosis due to drugs other
Rheumatoid nodules of the vocal cords as the initial manifestation of systemic lupus erythematosus
Authors: I. S. Schwartz
Journal: JAMA (1980)

INVOLVEMENT of the larynx in rheumatoid disease is not rare and is most commonly manifested as cricoarytenoid joint arthritis. While not symptomatic in all cases, it has been present in almost 50% of autopsies of patients with rheumatoid disease.<sup>1</sup>Less frequently, symptoms are due to laryngeal myositis or neuropathy of the recurrent laryngeal nerve, attributed to rheumatoid vasculitis.<sup>2</sup>There have been relatively few documented cases of rheumatoid nodule formation involving the vocal cords or other parts of the larynx.<sup>2-5</sup>These have been limited to patients with a previously established diagnosis of rheumatoid arthritis at the time of laryngeal symptomatology. We recently diagnosed rheumatoid granulomas on vocal cord biopsy material from a patient who had no evidence of rheumatoid disease or other connective tissue disorder at the time. During follow-up, she showed development of manifestations of systemic lupus erythematosus (SLE). <h3>Report of a Case</h3> A 28-year-old woman complained
UICC Postgraduate Courses on Clinical Cancer Chemotherapy
Journal: JNCI Journal of the National Cancer Institute (1979)

Journal Article UICC Postgraduate Courses on Clinical Cancer Chemotherapy Get access JNCI: Journal of the National Cancer Institute, Volume 62, Issue 5, May 1979, Page 1319, https://doi.org/10.1093/jnci/62.5.1319-b Published: 01 May 1979
Book Review The Principles of Anatomy: As seen in the hand . By Frederic Wood Jones, D.Sc. (Lond., Adelaide and Melbourne), F.R.S., F.R.C.S. Second edition. 8°, cloth, 418 pp., with 144 illustrations. Baltimore: The Williams and Wilkins Company, 1942. $7.50.
Journal: New England Journal of Medicine (1943)
The Organotypic Multicellular Spheroid Is a Relevant Three-Dimensional Model to Study Adenovirus Replication and Penetration in Human Tumors
Authors: J GRILL, M LAMFERS, V VANBEUSECHEM, C DIRVEN, D PHERAI, M KATER, P VANDERVALK, R VOGELS, W VANDERTOP, H PINEDO
Journal: Molecular Therapy (2002)

The use of adenoviruses for gene transfer and as oncolytic agents is currently receiving widespread attention. As specific constraints to adenovirus distribution and spread cannot be studied in cell cultures, there is a need for an in vitro three-dimensional (3D) model mimicking the in vivo biology of tumors. We studied the interactions between tumor and adenoviruses using multicellular spheroids grown from primary brain tumor material. Using β-galactosidase and luciferase reporter genes expressed by replication-defective adenoviruses, we showed that infection was restricted to the first layer of cells. Using a replication-competent adenovirus expressing the luciferase gene, we showed that transgene expression in the spheroid was considerably enhanced and that viral spreading deep into the 3D structure took place. In addition, a tetrazolium salt–based metabolic assay could be used to compare the oncolytic activity of different concentrations of replication-competent adenoviruses. We can conclude that organotypic spheroids offer a versatile in vitro system for studying distribution, spread, and oncolysis by adenoviruses in a clinically relevant model.
Inducing potency of aryl hydrocarbon hydroxylase activity in human lymphoblastoid cells and mice by polychlorinated dibenzofuran congeners.
Authors: J Nagayama, C Kiyohara, Y Masuda, M Kuratsune
Journal: Environmental Health Perspectives (1985)

Aryl hydrocarbon hydroxylase (AHH)-inducing potency of eight polychlorinated dibenzofuran (PCDF) isomers, 3,4,5,3',4',5'-hexachlorobiphenyl (HCB) and 2,3,7,8-tetrachlorodibenzo-p-dioxon (TCDD) in two inbred mouse strains (AHH responsive and nonresponsive mouse strains) and eight human lymphoblastoid cell lines (four males and four females) was investigated to evaluate their relative toxic potency. In AHH nonresponsive DBA mouse strain, only TCDD induced hepatic AHH activity at a dose of 30 micrograms/kg, while in AHH responsive C57 mouse strain, six PCDF isomers besides TCDD could enhance the enzyme activity significantly. 2,3,7,8-Tetrachlorodibenzofuran (2,3,7,8-TCDF), 1,2,3,7,8-pentachlorodibenzofuran (1,2,3,7,8-PCDF) and 2,3,4,7,8-pentachlorodibenzofuran (2,3,4,7,8-PCDF) showed the highest AHH inducing activity among the PCDF isomers tested. In contrast with the results obtained from the mouse experiments, in human lymphoblastoid cells, 2,3,4,7,8-PCDF, 1,2,3,4,6,7-hexachlorodibenzofuran (1,2,3,4,6,7-HCDF) and 1,2,3,7,8-hexachlorodibenzofuran (1,2,3,4,7,8-HCDF) elicited the highest AHH induction and were as potent AHH inducers as TCDD. These observations suggest that toxicities of 2,3,4,7,8-PCDF, 1,2,3,4,6,7-HCDF and 1,2,3,4,7,8-HCDF in human tissues may be comparable to that of TCDD. It was also observed that in both male and female human cell lines, the degree of AHH inducibilities of these compounds were roughly parallel to that of 3-methylcholanthrene, possibly indicating that genetic susceptibility among human population to the toxic compounds are also present similar to those reported among mouse strains.