tbuckley/cabot-search huggingface dataset:
Readability of informed consent forms for research in a Veterans Administration medical center
Authors: M. T. Baker
Journal: JAMA (1983)

This study examined the effects of federal regulations on the readability and length of consent forms used in medical research from 1975 through 1982. Materials evaluated were 49 information sheets from four sample time periods and the 1975 and 1979 revisions of the Veterans Administration consent document. Flesch readability scores were at college level for both the consent documents and information sheets from all sample time periods. Thus, consent forms always may have been too difficult for typical volunteers to comprehend. Changes in length and content of the consent documents suggest that difficulty levels actually may have increased since 1975. Efforts to protect the rights of research subjects through federal regulations have resulted in presentation of appropriate information, but little progress has been made in ensuring that the information is comprehensible, understood, and used. (<i>JAMA</i>1983;250:2646-2648)
J Coll Gen Practitioners, Dartmouth, England
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Mineralocorticoid Excess Syndrome Presumably Due to Excessive Secretion of Corticosterone
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 1613: Enhanced Expression of Tenascin-C in Granulomas of Patients With Active Cardiac Sarcoidosis
Authors: Fumio Terasaki, Michiaki Hiroe, Kyoko Imanaka-Yoshida, Bin Tsukada, Kaoru Otsuka, Takashi Katashima, Shuichi Fujita, Hiroaki Shimomura, Toshimichi Yoshida, Yasushi Kitaura
Journal: Circulation (2007)

Introduction: Tenascin-C (TN-C) is a member of the matricellular proteins that do not subserve a primary structural role, but function rather as modulators of cell-matrix interactions, with being evident at sites of inflammation, tissue remodeling or wound healing. Although TN-C is likely involved in the inflammatory process in the granulomatous tissue, their in situ expression in the sarcoid heart has not been clarified. Hypothesis: We assessed the hypothesis that serum levels of TN-C are increased in patients with sarcoidosis, and the expression of TN-C is upregulated in the myocardium of patients with active cardiac sarcoidosis. Methods: Serum TN-C levels were measured in 40 patients with sarcoidosis and 23 patients with idiopathic dilated cardiomyopathy (DCM). Sera from 20 normal volunteers served as controls. In addition, we immunohistochemically examined the expression profiles of TN-C in the myocardium from 12 patients with active cardiac sarcoidosis and 10 DCM patients. Results: Serum TN-C levels were significantly higher in patients with sarcoidosis than in normal controls [79.7±43.3 (SD) ng/ml vs. 30.9±8.8 ng/ml, p=0.001]. In the sarcoidosis group, serum TN-C levels in patients with definite cardiac involvement (n=10) were significantly higher than in those without it (n=30) (119.6±45.0 ng/ml vs. 66.4±34.0 ng/ml, p=0.005) and they were also higher than in DCM patients (vs. 68.2±24.3 ng/ml, p=0.006). Immunohistochemically, expression of TN-C was markedly enhanced in the extracellular matrix surrounding multinucleated giant cells and macrophages in the sarcoid granulomas. TN-C expression was limited to areas with well-formed, active granulomas. Conclusions: TN-C, produced in extracellular matrix, may be involved in the pathogenesis of sarcoid granulomas. The measurement of serum TN-C levels is useful for the diagnosis of sarcoidosis, and their higher levels may suggest the cardiac involvement.
MEXICO CITY
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE RIGHTS OF THE CHILD
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Williams Obstetrics
Authors: Nathan Kase
Journal: JAMA (1966)

<b>Beck's Obstetrical Practice</b>, by E. Stewart Taylor, ed 8; 658 pp, 735 illus, $14.50, Baltimore: Williams &amp; Wilkins Co., 1966. When established texts undergo revision, a major concern is how to build on the existing foundation a new edition which is contemporary in substance but does not sacrifice the successful qualities of the original work. This difficulty can be resolved only through careful compromises, which accommodate important new concepts but exclude diversions and fads which may preoccupy the current literature. Orderly adaptation of new material can be achieved by unusual competence and discretion on the part of the authors. In less fortunate circumstances, this resolution may be left to the passage of time, which delays incorporation of information and increases the frequency of necessary revision. Amidst the profusion of medical literature, the textbook must define the central issues of the subject and provide information in sufficient depth that the reader
THE ALCOHOLIC QUESTION AND THE INEBRIATE.
Journal: JAMA (1890)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Heroin Epidemics
Authors: Daniel X. Freedman
Journal: JAMA (1973)

In a number of studies in Metropolitan Chicago, Hughes and the University of Chicago group<sup>1-3</sup>have found that heroin addiction occurs in epidemics, that heroin use spreads from peer to peer, and that newly involved cases are much more "contagious" than are chronic cases. Microepidemics— 5 to 15 new cases over a five-year period—are seen in some locales, and macroepidemics—more than 50 new cases over a five-year period—in others. Hughes et al believe that macroepidemics are most likely in areas of high unemployment and crime, deterioration in housing, poor or absent neighborhood leadership, a large recent influx of povertylevel persons, and the many other expressions of urban blight. Their observations parallel those of Leighton et al,<sup>4</sup>who found a strong positive correlation between social disorganization and a wide range of behavior disorders. Exploratory work carried out by the Illinois Drug Abuse Program, a cooperative venture sponsored by the
Lysozyme
Authors: David Lagunoff
Journal: JAMA (1974)

All of us have accidents; few of us make significant discoveries. A drop of mucus from his running nose falling on a bacterial colony was the accident that led Fleming to his discovery of lysozyme, and, as if that weren't enough, it was Fleming's keenly "prepared mind" that later initiated the transmutation of a fungal contaminant on another bacterial culture into penicillin. This book is the record of a 1972 symposium commemorating Fleming's discovery of lysozyme in 1922. The contributions summarize both what is known of the biochemistry of lysozyme and what is unknown of its biology. It is ironic that our present knowledge of the structure of the enzymology of lysozyme exceeds that for almost any other enzyme, yet Fleming knew virtually all that is sure concerning lysozyme's functions. In a charming introductory essay, Lady Fleming quotes her husband "We shall hear more about lysozyme." We have and we
WHAT IS A "COMPETENT" PHYSICIAN?
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Maximal Lentivirus-Mediated Gene Transfer and Sustained Transgene Expression in Human Hematopoietic Primitive Cells and Their Progeny
Authors: S AMSELLEM, E RAVET, S FICHELSON, F PFLUMIO, A DUBARTKUPPERSCHMITT
Journal: Molecular Therapy (2002)

Gene therapy using permanent modifications of hematopoietic stem cells (HSC) has increasing potential applications for both genetic and acquired diseases. Considerable progress has been made recently in gene transfer to HSC by the use of lentivirus-derived vectors, which have the capacity to transduce noncycling cells. However, overall efficiency of HSC transduction reported so far is still not sufficient for numerous applications. We describe here an improved HSC transduction protocol, using the previously described lentiviral vector, that leads to more than 90% transduction of human CD34+ cells from cord blood, including NOD-LtSz-scid/scid repopulating cells. Moreover, under the same conditions, we transduce more than 75% and 80% of CD34+ cells mobilized in peripheral blood and from bone marrow, respectively. We further show that transgene expression is stable through time and hematopoietic cell differentiation in vitro as well as in vivo. Such a high HSC transduction efficiency opens new opportunities for both gene therapy applications and functional studies of regulator proteins of hematopoiesis.
CATS AS PLAGUE PREVENTERS
Authors: A. Buchanan
Journal: BMJ (1908)

ICATS AS PLAGUE PREVENTERS.[T BJazzus I231 'hospital, or licensed house.".Inquiry.shouldbe made as to whether it has been, necessary to forcibly hold the patient.downor to struggle.withhim or restrain him by .mechanicalmeans.. Also as to whether he has lately had falls or other accidents.If any of these events lhave -happened, a physical examination slhould be made.It is -a most unpleasant thing for all concerned, when a patient -is discovered on his arrival at the asylum to have broken ribs or severe, perhaps fatal, internal injuries, or to be suffering from small-pox or other infectious fever.This -section throws on,the certifier direct responsibility for the detection of such conditions and for proper precautions being taken. 5.The fifth head certifies that the medical man has at first read the section of the Act (printed at the foot of the page), An terms of which it is a misdemeanour to make any wilful ,misstatement in this or any other report or certificate '.under the Act.Then sign, as required, with full postal -address, and finally insert the date-that is, the date on which the certificate is written.This is usually the same *as the date on which the examination of the patient was .made,but it need not be so.
Studies on the Evaluation of the Toxicity of Various Salts of Lead, Manganese, Platinum, and Palladium
Authors: David J. Holbrook, Mildred E. Washington, Hansford B. Leake, Paul E. Brubaker
Journal: Environmental Health Perspectives (1975)

Preliminary studies have been conducted on various parameters in order to assess the possible and relative toxicities of a number of metallic salts. Upon oral administration in lethal-dose experiments, two soluble Pt4+ salts were more toxic than the other salts tested. Following intraperiotneal injection in lethal-dose experiments, PbCl2 was less toxic than several of the soluble or partially soluble salts of Pt4+, Pd2+, and Mn2+. An intake of a total of approximately 250 mg of Pt4+ per rat in the drinking fluid over a 30-day interval did not affect the activities of aniline hydroxylase and aminopyrine demethylase in rat liver microsomes. In rats receiving soluble Pt4+ salts in the drinking fluid, the highest concentration of Pt was found in the kidney and an appreciiable concentration was found in the liver.
A MILITARY PATHOLOGIC PROBLEM.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Comparative Toxicity and Tissue Distribution of Lead Acetate in Weanling and Adult Rats
Authors: J. I. Rader, J. T. Peeler, K. R. Mahaffey
Journal: Environmental Health Perspectives (1981)

The relative toxicity of low doses of lead acetate provided steadily in drinking water or by mouth once per week was studied in weanling and adult rats. Free erythrocyte protoporphyrin and urinary delta-aminolevulinic acid levels were measured, as well as lead levels in blood and kidney. The accumulation of lead in brain tissue and in bone (femur) was measured to determine the effect of age and schedule of administration on tissue distribution and retention of lead. Total intakes of lead during the 60-week experimental period were: weanling and adult rats exposed to drinking water supplemented with 200 microgram of lead acetate/ml: 127 +/- 10 mg and 160 +/- 16 mg, respectively; weanling and adult rats dosed with lead acetate orally once per week: 132 mg and 161 mg, respectively. Increased toxic effects of lead in the weanling animals were apparent in most of the parameters measured (urinary delta-aminolevulinic acid and blood, brain, femur and kidney lead levels). This pattern was observed in weanling rats exposed to lead steadily through drinking water or dosed orally with an equivalent quantity of lead once per week. Lead levels in blood were highly correlated with the accumulation of lead in brain, femur, and kidney tissue in both groups of weanling rats. In adult rats, significant correlations between blood lead and kidney lead and between blood lead and femur lead were found only in the rats receiving lead steadily in drinking water.
Mechanisms of Airway Narrowing and Hyperresponsiveness in Viral Respiratory Tract Infections
Authors: Richard G. Hegele, Shizu Hayashi, James C. Hogg, Peter D. Paré
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

Viral respiratory tract infections are associated with an acute increase in airway responsiveness in normal subjects and patients with asthma. Airway responsiveness is also increased at least transiently in animals during acute viral infections. In this article, we discuss possible mechanisms whereby viral infections can increase airway responsiveness, emphasizing the effects of viral-induced airway epithelial damage during acute lytic infection and the mechanical consequences of airway inflammation and edema, both internal and external to the smooth muscle layer. We also describe possible mechanisms by which acute lytic viral infections could induce chronic sequelae in atopic individuals and contribute to the development of persistence of asthma. Finally, results of recent studies from our laboratory that document adenoviral genome in lungs of patients with chronic obstructive pulmonary disease (COPD) and long-term persistence of respiratory syncytial viral genome and protein in an animal model are discussed in terms of the possible role of latent and persistent viral infections in the pathogenesis of asthma and COPD.
RELATION BETWEEN HEMODYNAMIC PARAMETERS ON ADMISSION AND WORSENING RENAL FUNCTION (WRF) IN EARLY PHASE IN PATIENTS WITH ACUTE DECOMPENSATED HEART FAILURE (ADHF)
Authors: Yuichi Kawase, Kazushige Kadota, Takeshi Tada, Takeshi Maruo, Harumi Katoh
Journal: Journal of the American College of Cardiology (2016)
One-Fifth of Nursing Posts Vacant
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Congenital Syphilis
Authors: Antonio C Arrieta, Jasjit Singh
Journal: New England Journal of Medicine (2019)

A 6-month-old girl whose parents had recently received a diagnosis of syphilis was referred for evaluation after testing suggested that she also had syphilis. Physical examination revealed frontal bossing and a soft-tissue perirectal mass. A biopsy specimen was positive for spirochetes on immunostaining.