tbuckley/cabot-search huggingface dataset:
Catch-up' hepatitis protection for adolescents
Authors: C. Marwick
Journal: JAMA (1994)

YOUNG ADOLESCENTS are urged to get immunized against hepatitis B. At its October meeting at the Centers for Disease Control and Prevention (CDC), Atlanta, Ga, the Advisory Committee on Immunization Practices unanimously voted to recommend that children who had not been vaccinated against hepatitis B should be immunized by the time they reach age 11 to 12 years. The committee's recommendation is part of a general statement on adolescent immunization that is in the drafting stage and probably will be issued early next year. Hepatitis B vaccine has been available since 1982, yet both acute and chronic hepatitis B infection remain a public health problem (<i>MMWR</i>. 1994; 43:605-608). Vaccination of adolescents has been part of the considered strategy to prevent disease transmission, but reaching this age group has been difficult because they do not routinely attend health care clinics or go to see physicians. "The concept is catch-up immunization. We
Palliative care in chronic obstructive pulmonary disease: a review for clinicians
Authors: David A Seamark, J Seamark Clare, David M G Halpin
Journal: Journal of the Royal Society of Medicine (2007)

Chronic obstructive pulmonary disease (COPD) is a progressive condition characterized by airflow obstruction which ultimately kills many patients. It is common in both men and women and there is a 24—30% 5-year survival rate in the UK for those with severe disease. The annual death rate in the UK from COPD approaches that from lung cancer. Patients’ symptoms can be improved by drug therapy, but stopping smoking is also an effective way of improving the outcome in patients at all stages of COPD. Predicting prognosis has been difficult in COPD due to the variable illness trajectory. However, assessment of severity of lung function impairment, frequency of exacerbations and requirement for long term oxygen therapy can help identify patients entering the final 12 months of life. Symptom burden and impact on activities of daily living for patients with COPD are comparable with that of cancer patients, and palliative care approaches are equally necessary, yet few publications exist to guide clinicians in this area. An evidence base exists for the management of dyspnoea with oxygen therapy and opioid drugs. There is less evidence for the effective treatment of depression and anxiety, fatigue and pain, and treatment is based on experience and considered best practice. This review discusses the problems that patients experience and offers practical guidance. The management of patients should be shared between primary and secondary care, with multidisciplinary teams being involved at an early stage. Patients and their families require honest and clear communication about the condition and what to expect in the future. The strict application of advance care planning and directives may not be feasible or appropriate, but there is evidence that attitudes towards resuscitation and artificial ventilation can be explored without distress. The requirement by patients and carers for surveillance and timely support is acknowledged, but how to provide such input is as yet unclear, with little evidence to support the widespread implementation of nurse-led management interventions. The hospice movement has become increasingly involved in the management of life-threatening, non-malignant disease and should be involved in the multidisciplinary care of patients dying from COPD.
Twelve-year "cure" of lung cancer with metastasis to the brain
Authors: W. H. Mosberg
Journal: JAMA (1976)

In managing lung cancer with metastasis to the brain, the clinician must decide whether to treat the primary lesion, the metastasis, neither, or both. A patient enjoying a useful survival of five years or more following treatment may be regarded as apparently cured. This patient was functioning normally twelve years after surgical treatment of the brain and lung lesions. Lung cancer with metastasis to the brain is not always a hopeless situation; occasionally a patient will derive great benefit from treatment. (<i>JAMA</i>235:2745-2746, 1976)
Author Omitted.
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Treatment of today's scabies and pediculosis
Authors: M. Orkin
Journal: JAMA (1976)

RECENTLY we noted<sup>1</sup>the increase of scabies in the United States following an eight-year pandemic in most of the world.<sup>2,3</sup>The cyclic nature of scabies epidemics is not understood, but immunologic factors, especially delayed hypersensitivity, probably play a significant role.<sup>4</sup>Based on extrapolation from experience in previous cycles in this century, the current epidemic may abate by approximately 1980. <h3>SCABIES</h3><h3>Principles of Management</h3> The diagnosis should be made with certainty, preferably by identifying the mite (principally in direct skin scrapings, at times by cutaneous biopsy) prior to instituting therapy. If the mite cannot be detected, there should be a review of suggestive features, and the more such features, the more positive is the diagnosis. A decision as to risk-to-benefit ratio must take into account the efficacy of the scabicide. Unfortunately, there has been limited interest in comparative, controlled efficacy trials of scabicides since World War II. The
Nuclear Medicine
Authors: Thomas P. Haynie
Journal: JAMA (1975)

Between 1968 and 1974, a series of articles concerning nuclear medicine appeared in<i>Hospital Practice</i>under the editorship of Henry N. Wagner Jr. The present book is a re-publication of those articles, updated at the end of 1974. Somehow it seems appropriate that this new approach to book production should recognize the newest of medical specialities, nuclear medicine. As the breadth and scope of nuclear medicine changes, it is difficult to produce a book about what nuclear medicine is and will be, rather than what it has been. The book is divided into sections on technology, clinical applications, and radioassay. A historical chapter in the beginning makes a good time-spanner to reduce the "future shock" of what follows. The section on technology is authored by such names as Beck, Anger, Winchell, Adelstein, in addition to Wagner. It discusses semiconductors, spark chambers, and tomographic scanners, computers, color, and ultra-short-lived positron emitters.
THE ILL-HEALTH OF RICHARD WAGNER.
Authors: GEORGE M. GOULD
Journal: JAMA (1903)

By no means is he out of the wood with his nerves, for he has to send apologies through Uhlig to another correspondent next day for not answering at once: "That sort of letter always takes a deal out of me." Not a word about the poem; nor in that to Liszt on the morrow, October 13. "Nothing further to-day. Used up as I am, it would only be lame.... Your old tormentor, Richard Wagner." On the 14th, just three days after the "forced pause" has been made in his poem, the migraine seems to have renewed its attack: "I wanted to work, but felt so ill that I had to pass the whole forenoon on the divan, half asleep, half awake. There'll have to be an alteration in me." That I have been unable to work to-day has terribly depressed me! How I should have liked a couple of days'
Editorial: Diagnosis of childhood spinal muscular atrophy.
Journal: BMJ (1973)

Starting YoungThough the dangers of cigarette smoking are plain enough to medical men they appear unconvincing to a large num- ber of lay people.But if the young are ever to be deterred from starting the habit at least one necessity is for their elders to set a better example than many do at present.Children would not be human if they did not imitate adults.That plenty do so to become smokers even at the age of 10 is apparent from a recent report.
Tobogganing injuries
Authors: K D Blake, B E Buckley, M A Meates
Journal: BMJ (1991)

Harold Shipman was an English general practitioner who murdered at least 215 of his patients between 1974 and 1998. A public inquiry is underway, but general practitioners and all doctors also need to consider the implications for their profession. The aim of this paper is to stimulate debate. Issues identified as important to consider include: trust between doctors; attitudes towards failing systems such as cremation certification; acceptance of the duty of accountability; ensuring patients can have reasonable confidence in their doctors; commitment to preventing such a case occurring again; and relationships with patients. It is argued that restricting debate to methods to detect doctors who murder would limit the opportunity to improve medical practice and would constitute a failure to fulfil the duty owed by doctors to Shipman’s victims and their families.
Confidential Spanish Registry of HIV-Infected Individuals
Authors: X. Bosch
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
EXPERT MEDICAL ADVICE FOR FOREIGN COUNTRIES
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Termination of Cardiopulmonary Resuscitation for Out-of-Hospital Cardiac Arrest—Reply
Authors: Arthur B. Sanders
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Assessing Medicare's prospective payment system
Authors: C. Davis
Journal: JAMA (1987)

Sager et al<sup>1</sup>raise some interesting and important issues in this issue ofThe Journal. By reviewing hospitalization and mortality data for the Wisconsin-Medicaid elderly population in nursing homes and comparing the data with those for the noninstitutionalized Medicaid population, the authors claim a strong causal relationship between the advent of a prospective payment system (PPS) to hospitals and the rise in admissions to hospitals of the institutionalized elderly Medicaid patients. Likewise, they compare these two population groups for length of stay in the hospitals, noting a significantly greater decrease in length of stay for the institutionalized Medicaid patients than for the noninstitutionalized. Last, they describe a shift in mortality rates, with an increase in nursing home deaths and a corresponding decrease in hospital deaths. This study raises a number of significant issues that I will address, although I may be perceived as somewhat defensive of a system that
Oxytuberculin.
Authors: E. H. Smith
Journal: JAMA (1898)

Santa Clara, Cal., March 15, 1898. <h3>To the Editor:</h3> —In theJournalof March 12, 1898 (p. 621), Dr. J. O. Hirschfelder writes of "Oxytuberculin." In his article he states that "it was and is my desire that the doctrine of the curative effect of oxidized toxins should be most skeptically investigated, etc." That is just what I have been doing. The more I investigate the more skeptic I become, especially as regards "oxytuberculin." As to the Doctor not having "entered upon the field of animal experimentation, but limiting my work entirely to the clinical and bacteriologic sphere, etc.," I beg leave to call Dr. Hirschfelder's attention to plate 1, page 268 of the "Transactions of the Medical Society of the State of California" for 1897. This plate shows a dog upon whom the Doctor claimed to have experimented. The same plate, or one purporting to be the same, appeared
Call for Stepped-up Research on Antidepressant Use During Pregnancy
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Platelets Constitutively Express Interleukin-33 Protein and Modulate Eosinophilic Airway Inflammation
Authors: Tomohiro Takeda, Hirotoshi Unno, Hideaki Morita, Kyoko Futamura, Maiko Sugie, Ken Arae, Susumu Nakae, Hirohisa Saito, Kenji Matsumoto, Akio Matsuda
Journal: Journal of Allergy and Clinical Immunology (2015)
A program to recruit and educate medical students to practice family medicine in underserved areas
Authors: H. K. Rabinowitz
Journal: JAMA (1983)

In an attempt to address the problem of physician maldistribution, Jefferson Medical College initiated the Physician Shortage Area Program (PSAP) in 1974, a special admissions program that preferentially selects applicants who intend to practice family medicine in physician shortage areas in Pennsylvania. Forty-seven students in four classes have been graduated from the program. Evaluation of these students during medical school shows that their academic performance has been similar to their classmates. Follow-up evaluation indicates that PSAP graduates are five times as likely as their peers (non-PSAP) to enter a family medicine residency program during the first postgraduate year (62% v 12%), and almost twice as likely to enter family medicine as a comparable group of non-PSAP students who originally entered Jefferson with plans of becoming a family physician (62% v 33%). (<i>JAMA</i>1983;249:1038-1041)
PHENOLPHTHALEIN INTOXICATION
Authors: BEN A. NEWMAN
Journal: JAMA (1933)

Phenolphthalein has been generally looked on as a harmless drug, and because of the ease of administration it has gained very wide usage. In 1918, Abramowitz<sup>1</sup>and Fox<sup>2</sup>pointed out that in susceptible persons the ingestion of phenolphthalein causes a peculiar eruption of the skin. Since then, numerous reports have appeared in the literature of atypical as well as typical eruptions, and in a few instances visceral disturbances have been reported. At present the dermatosis is familiar, nineteen patients with phenolphthalein eruptions having been observed in our own clinic during the past year. The characteristic eruption is easy for the dermatologist to recognize immediately on inspection. As far as is known, only three other substances, antipyrine, arsphenamine (neoarsphenamine) or amidopyrine, are capable of provoking identical eruptions. The eruption may be spread over the entire body or may be confined to favorite sites, as the forearms, neck or thighs.
Induction of potent antitumor immunity by in situ targeting of intratumoral DCs
Authors: Katsuyoshi Furumoto, Luis Soares, Edgar G. Engleman, Miriam Merad
Journal: Journal of Clinical Investigation (2004)

Recent reports of tumor regression following delivery of autologous tumor antigen–pulsed DCs suggest that defective antigen presentation may play a key role in tumor escape. Here we show in two different murine tumor models, CT26 (colon adenocarcinoma) and B16 (melanoma), that the number and activation state of intratumoral DCs are critical factors in the host response to tumors. We used CCL20/macrophage inflammatory protein-3α (MIP-3α) chemokine to increase the number of tumoral DCs and intratumoral injections of CG-rich motifs (CpGs) to activate such cells. Expression of CCL20 in the tumor site attracted large numbers of circulating DCs into the tumor mass and, in the case of CT26 tumors, led to complete tumor regression. Intratumoral CpG injections, in addition to CCL20, were required to induce therapeutic immunity against B16 tumors. In this model CpG overcame tumor-mediated inhibition of DC activation and enabled tumoral DCs to cross-present tumor antigens to naive CD8 T cells. CpG activation of tumoral DCs alone was not sufficient to induce tumor regression in either tumor model, nor was systemic delivery of the DC growth factor, Flt3 ligand, which dramatically increased the number of circulating DCs but not the number of tumoral DCs. These results indicate that the number of tumoral DCs as well as the tumor milieu determines the ability of tumor-bearing hosts to mount an effective antitumor immune response. Our results also suggest that DCs can be manipulated in vivo without delivery of defined tumor antigens to induce a specific T cell–mediated antitumor response and provide the basis for the use of chemokines in DC-targeted clinical strategies.
The role of the school and the community in sex education and related problems
Authors: T. E. Shaffer
Journal: JAMA (1966)

There is a universal feeling that not enough nor the right kind of sex education is being done at home, in the school, or elsewhere. Most parents, teachers, physicians, ministers, nurses, youth leaders, and school and college youth would agree that there could be improvements. Sex education is a complex topic. There is, however, as we all know, more to it than classroom instruction, because under this "umbrella" are a number of related but individual goals. Among these are answering simple questions of children; supplying facts about the anatomy and physiology of the organs of reproduction; providing help and direction to boys and girls in establishing appropriate masculine and feminine roles; developing acceptable sexual behavior; preparation for marriage; a foundation for responsible parenthood and achievement of a happy, stable family life; comprehending the issues in population controls; teaching the importance of preventing certain infectious diseases; and reducing the problems of