tbuckley/cabot-search huggingface dataset:
THE FATE OF FOREIGN PARTICLES IN THE BLOOD STREAM
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Primer of Psychology and Mental Diseases for the Use of Training Schools for Attendants and Nurses and in Medical Classes.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Formation and Persistence of Arylamine DNA Adducts In Vivo
Authors: Frederick A. Beland, Fred F. Kadlubar
Journal: Environmental Health Perspectives (1985)

Aromatic amines are urinary bladder carcinogens in man and induce tumors at a number of sites in experimental animals including the liver, mammary gland, intestine, and bladder. In this review, the particular pathways involved in the metabolic activation of aromatic amines are considered as well as the specific DNA adducts formed in target and nontarget tissue. Particular emphasis is placed on the following compounds: 1-naphthylamine, 2-naphthylamine, 4-aminobiphenyl, 4-acetylaminobiphenyl, 4-acetylamino-4'-fluorobiphenyl, 3,2'-dimethyl-4-aminobiphenyl, 2-acetylaminofluorene, benzidine, N-methyl-4-aminoazobenzene, 4-aminoazobenzene, and 2-acetylaminophenanthrene.
A Textbook of Bacteriology and Its Applications.
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Targeting EXT-1 Reveals a Crucial Role of Heparan Sulfate in the Growth of Multiple Myeloma.
Authors: Rogier M Reijmers, Richard W.J. Groen, Henk Rozemuller, Annemieke Kuil, Anneke de Haan - Kramer, Tamas Csikos, Anton C.M. Martens, Marcel Spaargaren, Steven T Pals
Journal: Blood (2009)
Radio-Guided Lymph Node Mapping in Bladder Cancer Using SPECT/CT and Intraoperative γ-Probe Methods
Authors: Wojciech Połom, Agnieszka Gruszecka, Marcin Markuszewski, Wojciech Cytawa, Piotr Lass, Marcin Matuszewski
Journal: Clinical Nuclear Medicine (2017)

Połom, Wojciech MD; Gruszecka, Agnieszka; Markuszewski, Marcin MD, PhD; Cytawa, Wojciech MD; Lass, Piotr MD, PhD; Matuszewski, Marcin MD, PhD Author Information
Two New Intra-Articular Injections for Knee Osteoarthritis
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Anatomy
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Isolated systolic hypertension and subclinical cardiovascular disease in the elderly. Initial findings from the Cardiovascular Health Study
Authors: B. M. Psaty
Journal: JAMA (1992)

<h3>Objective.</h3> —To assess the association between isolated systolic hypertension (ISH) and subclinical disease in adults aged 65 years and above. <h3>Design.</h3> —Medicare eligibility lists were used to obtain a representative sample of 5201 community-dwelling elderly persons for the Cardiovascular Health Study, a National Heart, Lung, and Blood Institute—sponsored cohort study of risk factors for coronary heart disease and stroke. In this cross-sectional analysis of baseline data, we excluded 3012 participants who were receiving antihypertensive medications, had clinical cardiovascular disease, or had a diastolic blood pressure of at least 90 mm Hg. <h3>Main Outcome Measures.</h3> —For electrocardiogram: myocardial infarction, left ventricular hypertrophy, and left ventricular mass as measures of myocardial damage and strain; for echocardiography: left ventricular mass, fractional shortening, and Doppler flow velocities as measures of cardiac systolic and diastolic function; and for carotid sonography: carotid arterial intima-media thickness as a measure of atherosclerosis. <h3>Results.</h3> —Among the 2189 men and women in this analysis, 195 (9%) had ISH (systolic blood pressure, ≥160 mm Hg) and 596 (23%) had borderline ISH (systolic blood pressure, 140 to 159 mm Hg). Systolic blood pressure was associated with myocardial infarction by electrocardiogram (<i>P</i>=.02). Borderline and definite ISH were strongly associated with left ventricular mass (<i>P</i>&lt;.001). While there was little association with cardiac systolic function, borderline and definite ISH were associated with cardiac diastolic function (<i>P</i>&lt;.001). Isolated systolic hypertension was also strongly associated with increased intima-media thickness of the carotid artery (<i>P</i>&lt;.001). <h3>Conclusions.</h3> —While cohort analyses of future repeated measures will provide a better assessment of risk, both borderline and definite ISH were strongly related to a variety of measures of subclinical disease in elderly men and women. (<i>JAMA</i>. 1992;268:1287-1291)
CHRONIC APPENDICITIS
Authors: JOHN A. LICHTY
Journal: JAMA (1922)

however, solid union of the fracture had taken place.Dis¬ charging sinuses due to a traumatic osteomyelitis remained.It should be stated in explanation of this unusual failure of metabolic response that the patient was a diabetic, a condition in which the whole acid-base metabolism may be altered.In addition we have some evidence which leads us to believe that patients with discharging sinuses have a low phosphate curve under circumstances which ordinarily would produce a sharp rise.Whatever may be the explanation of the low phosphate curve of this patient, the outstanding fact is that the local mechanism was able to produce normal calcification without a high concentration of phosphate in the serum.On the other hand, the second case of nonunion which came under our observation afforded evidence that a normal rise in the phosphates is not of itself sufficient to insure union :M. W. suffered a fracture of the tibia.After treatment by fixation for nine weeks, there was no clinical evidence of union, and roentgen-ray examination did not detect any callus.Examination of the blood serum revealed the usual rise in the phosp'tiate content (Chart 5).This is apparently a case in which every factor in the healing of fractures was normal, except the mecha¬ nism whereby bone salts are precipitated at the local O 16J>ays after fracture Chart 5.-Phosphate content of the serum of W. W., with simple fracture of the tibia ' and fibula, treated by fixation in plaster.Eight weeks after fracture there was no evidence of union on either clinical or roentgenographic examination.This appears to be evidence of the importance of the local mechanism as contrasted with the metabolic mechanism in the healing of fractures.focus.These two cases appear to point to the impor¬ tance of a local process, the exact mechanism of which is as yet unknown.It is known that the rate of healing of fractures varies with the age of the patient, and union is more rapid in young than in old persons.We have found that the increase in the blood serum phosphate which occurs after fractures takes place much more rapidly in young than in old persons.An increase which occurs in two to three weeks in adults takes place in patients under 25 years of age in less than one week.Whether the delayed response of the general inorganic metabolism of the body to a fracture accounts for the slower unión in elderly patients, or whether it is due also to a delayed response of the local factor, we do not know.Further investigations are being carried out in an endeavor to throw more light on this interesting problem.CONCLUSIONS 1.The inorganic phosphate content of normal serum frqrmbirth to 20 years of age is remarkably constant.At this agerit drops sharply to a lower concentration, and is again remarkably constant at this lower level throughout adult life.
LAW AND MEDICINE
Authors: George E. Hall
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Erratum
Journal: Diabetes Care (1990)

In the article titled “Fructose-2,6-Bisphosphate in Control of Hepatic Gluconeogenesis: From Metabolites to Molecular Genetics,” by Simon J. Pilkis, M.R. El-Maghrabi, and T.H. Claus {Diabetes Care 13:582-99, 1990) on p. 583, lines 47 and 48 should read “Control of gluconeogenesis occurs on three levels. The first involves regulation of substrate supply.”
Die Hormone
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Phase 1 open label trial of intraperitoneal paclitaxel (IPP) in combination with intravenous cisplatin (C) and oral capecitabine (X) in patients with advanced gastric cancer and peritoneal metastases.
Authors: Sina Vatandoust, Tim F Bright, M Nazim Abbas, Amitesh Chandra Roy, David I. Watson, Susan S H Gan, Alex Scott-Hoy, Jeff A Bull, Christos Stelios Karapetis
Journal: Journal of Clinical Oncology (2019)

4061 Background: IPP is a potential treatment option in patients with gastric cancer with peritoneal metastasis. IPP with a dose of 20 mg/m2 is well tolerated in combination with S1; however, this has been achieved in a specific genetic pool (Japanese population), and S1 is not available in some countries. We investigated the Maximum Tolerated Dose (MTD) of IPP in addition to a standard chemotherapy combination in an Australian population. Methods: Study population included synchronous or metachronous metastatic HER-2 non-amplified gastric adenocarcinoma with histologically/cytologically proven peritoneal involvement and adequate organ function. Intra-peritoneal catheter was placed surgically. 3 + 3 standard dose-escalation design was used. MTD was defined as the highest dose level at which ≤ 33% of patients had Dose Limiting Toxicity (DLT). DLT was defined within the first 3 cycles. Recommended Phase-2 Dose was defined as equal to the MTD, or cohort-3 dose if MTD was not reached. Treatment: maximum of six 21-day cycles of C (80mg/m2 IV day 1) + X (1000mg/m2 PO BD days 1-14) + IPP (days 1 and 8). IPP doses for Cohort-1, 2 and 3 were 10, 20 and 30mg/m2 respectively. Primary endpoint was the MTD of IPP. Secondary endpoints included safety, tolerability, overall response rate, ascites response rate, progression free survival and overall survival. Results: 15 patients were recruited in 3 cohorts: 9 males (60%), median age at study entry: 61y (range 32-82). All had synchronous metastatic disease and were chemo-naïve. Cohort-1 expanded to 6 patients due to 1 DLT (grade 3 diarrhea), cohort-2 included 3 patients (no DLT) and cohort-3 was expanded to 6 patients as planned and 1 DLT occurred (febrile neutropenia). MTD was not reached and Recommended Phase 2 Dose was determined as 30mg/m2. 8 patients (53%) completed all 6 cycles of treatment. The last patient on the study has completed 3 cycles and is expected to complete 6 cycles by April 2019. No grade 4 or 5 toxicity was recorded. Conclusions: MTD of IPP was not reached. IPP is safe in combination with C + X and the Recommended Phase 2 Dose is 30 mg/m2. Survival data will be presented when available. Clinical trial information: ACTRN12614001063606.
Vaginitis
Authors: M. G. Good
Journal: BMJ (1957)

<h3>Objective:</h3> To determine whether low vitamin D concentrations are associated with an increased risk of incident all-cause dementia and Alzheimer disease. <h3>Methods:</h3> One thousand six hundred fifty-eight elderly ambulatory adults free from dementia, cardiovascular disease, and stroke who participated in the US population–based Cardiovascular Health Study between 1992–1993 and 1999 were included. Serum 25-hydroxyvitamin D (25(OH)D) concentrations were determined by liquid chromatography-tandem mass spectrometry from blood samples collected in 1992–1993. Incident all-cause dementia and Alzheimer disease status were assessed during follow-up using National Institute of Neurological and Communicative Disorders and Stroke/Alzheimer9s Disease and Related Disorders Association criteria. <h3>Results:</h3> During a mean follow-up of 5.6 years, 171 participants developed all-cause dementia, including 102 cases of Alzheimer disease. Using Cox proportional hazards models, the multivariate adjusted hazard ratios (95% confidence interval [CI]) for incident all-cause dementia in participants who were severely 25(OH)D deficient (&lt;25 nmol/L) and deficient (≥25 to &lt;50 nmol/L) were 2.25 (95% CI: 1.23–4.13) and 1.53 (95% CI: 1.06–2.21) compared to participants with sufficient concentrations (≥50 nmol/L). The multivariate adjusted hazard ratios for incident Alzheimer disease in participants who were severely 25(OH)D deficient and deficient compared to participants with sufficient concentrations were 2.22 (95% CI: 1.02–4.83) and 1.69 (95% CI: 1.06–2.69). In multivariate adjusted penalized smoothing spline plots, the risk of all-cause dementia and Alzheimer disease markedly increased below a threshold of 50 nmol/L. <h3>Conclusion:</h3> Our results confirm that vitamin D deficiency is associated with a substantially increased risk of all-cause dementia and Alzheimer disease. This adds to the ongoing debate about the role of vitamin D in nonskeletal conditions.
Further Observations on the Isolated Human Jejunum
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
6. Glycemic Targets: <i>Standards of Medical Care in Diabetes—2021</i>
Journal: Diabetes Care (2020)

The American Diabetes Association (ADA) “Standards of Medical Care in Diabetes” includes the ADA's current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA Professional Practice Committee, a multidisciplinary expert committee (https://doi.org/10.2337/dc21-SPPC), are responsible for updating the Standards of Care annually, or more frequently as warranted. For a detailed description of ADA standards, statements, and reports, as well as the evidence-grading system for ADA's clinical practice recommendations, please refer to the Standards of Care Introduction (https://doi.org/10.2337/dc21-SINT). Readers who wish to comment on the Standards of Care are invited to do so at professional.diabetes.org/SOC.