tbuckley/cabot-search huggingface dataset:
Cell-surface fibronectin
Authors: K. M. Yamada
Journal: JAMA (1980)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Development of a fully human T cell engaging bispecific antibody for the treatment of multiple myeloma.
Authors: Ben Buelow, Duy Pham, Starlynn Clarke, Shelley Force Aldred, Kevin Dang, Payal Pratap, Harshad Ugamraj, Katherine Harris, Nathan Trinklein, Ute Schellenberger, Arun Wiita, Wim Van Schooten, Ben Buelow
Journal: Journal of Clinical Oncology (2017)

8017 Background: Although BCMA is a plasma cell specific surface molecule attractive as an antibody target in multiple myeloma, its scarcity on the cell surface may limit the efficacy of a conventional antibody. T-cell engaging bispecific antibody approaches are highly efficacious and are particularly well suited for a membrane target with limited expression, such as BCMA. Teneobio has developed a multivalent antibody platform based on modular human VH domains, which allowed us to build T cell engaging bispecific antibodies with low and high T cell agonistic activities. Methods: UniRats were immunized with either CD3 or BCMA antigens and antigen-specific UniAbs were identified by antibody repertoire sequencing and high-throughput gene assembly, expression, and screening. High affinity binding VH sequences were selected using recombinant proteins and cells. In vitro efficacy studies included T-cell activation by cytokine- and tumor cell kill by calcein-release assays. In vivo efficacy of the molecules was evaluated in NSG mice harboring myeloma cells and human PBMCs. Results: BCMA-specific UniAbs bound plasma cells with high affinities (100-700pM) and cross-reacted with cynomolgus plasma cells. Strong and weak T cell agonists were identified that bound human T cells with high and low affinities respectively and cross-reacted with cynomolgus T cells. T cell engaging bispecifics with a strong (H929 cytotoxicity:EC 50 =27pM) and a weak T cell activating arm (H929 cytotoxicity: EC 50 =1170pM) demonstrated T-cell activation and tumor-cell cytotoxicity in vitro; bispecifics with a weak CD3 engaging arm showed markedly reduced cytokine production even at doses saturating for cytotoxicity. In viv o, BCMAxCD3 bispecific antibodies reduced tumor load and increased survival when co-administered with human PBMCs as compared to controls. Conclusions: Our results suggest that T cell engaging bispecifics with low-affinity anti-CD3 arms could be preferred for the treatment of Multiple Myeloma.
BERLIN
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Error in Trends, Major Medical Complications, and Charges Associated With Surgery for Lumbar Spinal Stenosis in Older Adults
Authors: R. A. Deyo, S. K. Mirza, B. I. Martin
Journal: JAMA (2011)

To the Editor: We recently discovered an analytical error in our study on lumbar stenosis surgery.1 This affects our results regarding time trends for surgical procedures (Figure in the article) but not the data concerning complications or charges.
Different Genomic Changes Underlie Adaptive Evolution in Populations of Contrasting History
Authors: Sofia G Seabra, Inês Fragata, Marta A Antunes, Gonçalo S Faria, Marta A Santos, Vitor C Sousa, Pedro Simões, Margarida Matos
Journal: Molecular Biology and Evolution (2019)

Experimental evolution is a powerful tool to understand the adaptive potential of populations under environmental change.Here, we study the importance of the historical genetic background in the outcome of evolution at the genomewide level.Using the natural clinal variation of Drosophila subobscura, we sampled populations from two contrasting latitudes (Adraga, Portugal and Groningen, Netherlands) and introduced them in a new common environment in the laboratory.We characterized the genome-wide temporal changes underlying the evolutionary dynamics of these populations, which had previously shown fast convergence at the phenotypic level, but not at chromosomal inversion frequencies.We found that initially differentiated populations did not converge either at genome-wide level or at candidate SNPs with signs of selection.In contrast, populations from Portugal showed convergence to the control population that derived from the same geographical origin and had been long-established in the laboratory.Candidate SNPs showed a variety of different allele frequency change patterns across generations, indicative of an underlying polygenic basis.We did not detect strong linkage around candidate SNPs, but rather a small but longranging effect.In conclusion, we found that history played a major role in genomic variation and evolution, with initially differentiated populations reaching the same adaptive outcome through different genetic routes.
A forecast of disaster for Pakistan
Authors: None The Lancet
Journal: The Lancet (2005)

More than 100 000 men, women, and children are dead as a result of the earthquake that hit Pakistan on Oct 8. And the same number again will likely perish over the coming months as the 3 million people left homeless prepare to face the unforgiving Himalayan winter. The effects on children have been especially devastating—almost 40 000 deaths, and hundreds of spinal injuries and amputations. The priorities, as set out by WHO, are clear: to maximise access to health care; prevent disease and suffering; and to address the mental-health needs of a population struggling to come to terms with the loss of family and friends, possessions, and livelihoods.
Pathogenesis of diquat-induced liver necrosis in selenium-deficient rats: Assessment of the roles of lipid peroxidation and selenoprotein P*1
Authors: R BURK
Journal: Hepatology (1995)

A dose of diquat below the amount injurious to selenium-replete animals causes lipid peroxidation and massive liver necrosis in selenium-deficient rats. The current study was undertaken to characterize the lipid peroxidation with respect to the liver injury and to correlate the presence of several selenoproteins with the protective effect of selenium. Lipid peroxidation was assessed by measurement of F2 isoprostanes. Diquat caused an increase in liver and plasma F2 isoprostanes. A gradient of these compounds was detected across the liver in some animals, indicating that this organ was a source of some of the plasma F2 isoprostanes. A time-course experiment showed that liver F2 isoprostane concentration increased before plasma alanine transaminase (ALT) levels rose. Selenium-deficient rats were injected with selenium doses from 2 to 50 μg/kg and studied 12 hours later. A dose of 10 μg/kg or more prevented diquat-induced lipid peroxidation and liver injury. This dose increased plasma selenoprotein P substantially, and a dose-response was present. Liver cellular and plasma glutathione peroxidase activities remained below 2% of their values in control rats for all selenium doses. In selenium-deficient rats given diquat, hepatic lipid peroxidation precedes hepatic necrosis and could therefore be an important mechanism of the necrosis. Selenoprotein P levels were increased by selenium injections, which protected against diquat injury, but glutathione peroxidase activity was not increased. This is consistent with selenoprotein P being the mediator of the selenium effect.
Reply:
Authors: Marina Berenguer
Journal: Hepatology (2009)

In patients infected with HCV who have end-stage renal disease, patient survival is significantly better with kidney transplantation compared to remaining on hemodialysis. However, HCV infection has a detrimental effect on survival after kidney transplantation.1 Unfortunately, interferon-based therapy is not recommended after renal transplantation because of the risk of acute rejection and graft dysfunction. Therefore, eradication of this virus should be actively pursued before transplantation. Preliminary data support the efficacy of interferon-based therapy in this setting, but the experience with pegylated interferon formulations is still limited, and it is still unclear whether there are differences between the two pegylated interferons.2 Although ribavirin is usually not recommended in these patients because the drug is not removed during conventional dialysis and its accumulation causes a dose-dependent hemolytic anemia, recent promising data involve the combination of pegylated interferon and reduced dose of ribavirin with ribavirin plasma concentration monitoring. The data though are still limited to a few studies that include small sample sizes.3, 4 We therefore fully agree with Dr. Casanova that there is a need for additional research, particularly controlled clinical studies to assess the potential benefits of adding ribavirin, the potential differences of the two pegylated interferons, as well as analyzing the impact of the dialysis technique on treatment outcome. Marina Berenguer*, * Hepatogastroenterology Service, Hospital La Fe, Facultad de Medicina de la Universidad de Valencia, Valencia, Spain and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD).
Ophthalmoplegia Syndromes
Authors: ALBERT S. LEVEILLE
Journal: Annals of Internal Medicine (1980)

Letters and Corrections1 December 1980Ophthalmoplegia SyndromesALBERT S. LEVEILLE, M.D., FRANK W. NEWELL, M.D.ALBERT S. LEVEILLE, M.D.Search for more papers by this author, FRANK W. NEWELL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-93-6-931_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We read with interest the paper "Mitral Valve Prolapse and Ophthalmoplegia: A Progressive, Cardioneurologic Syndrome" by Darsee and associates (1). We wish to comment on several points.Some of the confusion regarding patients with external ophthalmoplegia, heart block, and other abnormalities arises because of the overused, obfuscating term "ophthalmoplegia plus" that links clinically similar conditions obviously not related. Patients with external ophthalmoplegia, retinal pigmentary degeneration, heart block, and other abnormalities, who do not have Bassen-Kornzweig or Refsum diseases, have the Kearns-Sayre syndrome. Cases with only one or two findings, but not the complete triad, should be referred...References1. DARSEEMIKLOZEKHEYMSFIELDHOPKINSWENGER JCSLN. Mitral valve prolapse and ophthalmoplegia: a progressive, cardioneurologic syndrome. Ann Intern Med. 1980;92:735-41. LinkGoogle Scholar2. WILNERCOLLINSVICKKILLIP GPNT. Cardiovascular-neurologic correlations in Kearn's syndrome. Clin Res. 1976;24:561A. Abstract. Google Scholar3. LEVEILLENEWELL AF. Autosomal dominant Kearns-Sayre syndrome. Ophthalmology. 1980;87:99-108. CrossrefMedlineGoogle Scholar4. BASTIAENSEN L. Chronic Progressive External Ophthalmoplegia. Winchester, Massachusetts: Sijthoff-Noordoff International Publishers; 1978;323-40. Google Scholar5. HYMANPATTENDODSON BBR. Mitochondrial abnormalities in progressive external ophthalmoplegia. Am J Ophthalmol. 1977;83:362-71. CrossrefMedlineGoogle Scholar6. NEWELLPOLASCIK FM. Mitochondrial Disease and Retinal Pigment Degeneration. Amsterdam: Excerpta Medica, 1979:615-7. (International Congress Series no. 450.) Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Eye Research Laboratories University of Chicago Chicago, IL 60637 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1980Volume 93, Issue 6Page: 931-931KeywordsHeartHeart diseasesMitral valve prolapse Issue Published: 1 December 1980 PDF DownloadLoading ...
Adaptive coping mechanisms in adult acute leukemia patients in remission
Authors: J. B. Sanders
Journal: JAMA (1977)

The adult leukemia patient in a drug-induced remission possesses a unique set of emotional responses as he adjusts to an altered life-style and a life-threatening disease. Six patients, ranging in age from 24 to 62 years and being treated with monthly maintenance chemotherapy, were interviewed over a six-month period. The adaptive coping mechanisms most frequently identified were denial of being sick, identification with fellow patients to form a "hospital family," and anticipatory grief of one's own losses by participation in grieving another patient's death. The means of adjustment was to adapt to the "hospital family" and benefit from the therapeutic milieu established on the ward. The patient's total response to remission in acute leukemia can be influenced positively by appropriate intervention based on an assessment of his previous and present patterns of coping. (<i>JAMA</i>238:952-954, 1977)
THE NEW GOSPEL OF DIRT.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
From the Centers for Disease Control and Prevention. Availability of diabetes information on the Internet
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Results of the interim analysis of the EORTC randomized phase III CATNON trial on concurrent and adjuvant temozolomide in anaplastic glioma without 1p/19q co-deletion: An Intergroup trial.
Authors: Martin J. Van Den Bent, Sara Erridge, Michael A. Vogelbaum, Anna K. Nowak, Marc Sanson, Alba Ariela Brandes, Wolfgang Wick, Paul M. Clement, Jean-Francois Baurain, Warren P. Mason, Helen Wheeler, Olivier L. Chinot, Michael Weller, Vassilis Golfinopoulos, Ken Aldape, Winand N.M. Dinjens, Pieter Wesseling, Thierry Gorlia, Johan M Kros, Brigitta G. Baumert
Journal: Journal of Clinical Oncology (2016)

LBA2000 The full, final text of this abstract will be available at abstracts.asco.org at 2:00 PM (EDT) on Friday, June 3, 2016, and in the Annual Meeting Proceedings online supplement to the June 20, 2016, issue of the Journal of Clinical Oncology. Onsite at the Meeting, this abstract will be printed in the Sunday edition of ASCO Daily News.
Correction: Risk of disability and mortality due to overweight in a Finnish population
Journal: BMJ (1990)

Plastic bullets have been available to police forces in the United Kingdom since 1988' but have been used to control public disorder and riots in Northern Ireland since 1975.They were intended to be more accurate and no more damaging than the rubber bullet that they replaced.2They are unique in that they are fired to inflict non-penetrating blunt trauma in an effort to immobilise rather than kill.Over 54 000 rounds were fired during the 13 years of this study from 1975.In this time 80 patients presented to hospitals in Belfast with injuries to the chest caused by plastic bullets.We assessed the outcome of these injuries.
High-Dose Oral Vitamin D Supplementation and Risk of Falls in Older Women
Authors: Maurizio Gallieni
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Yellow Fever.
Authors: Irving C. Rosse
Journal: JAMA (1899)

Washington, D. C., Aug. 5, 1899. <h3>To the Editor.</h3> —Among the outbreaks of yellow fever that have prevailed at Fortress Monroe, Va., and its vicinity let me mention one that has never been reported. In the early part of August, 1869, I had just come from quarantine duty at the mouth of the Rio Grande River, Texas, and being ordered to Fortress Monroe, found a French man-of-war quarantined in Hampton Roads because of yellow fever. Many of the crew having died, as well as the medical officers, the ship was visited daily by a surgeon from the fort, who went unrestrained about his duties after coming ashore. It was not long, however, before an unmistakable case of the fever broke out in a member of the family of one of the surgeons who had most to do with the fever patients on shipboard. We decided to keep the matter strictly
The Prospective Mother:. A Handbook for Women During Pregnancy
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal