tbuckley/cabot-search huggingface dataset:
Annals of Oncology
Authors: George J. Bosl
Journal: JAMA (1993)

<i>Annals of Oncology</i>, the official journal of the European Society of Medical Oncology, is in its third year of publication. In its inaugural issue, Dr Cavalli, the editor-in-chief, wrote that "the journal's inception is primarily the expression of a rapidly changing European reality." Furthermore, it "reflects a recognition of the rapidly expanding amount of oncologic research being carried out in Europe, and its primary goal is the expeditious publication of the results of this research." The journal's instructions to authors state that<i>Annals of Oncology</i>publishes manuscripts that "describe new findings of particular significance in any area related to clinical oncology and clinically oriented basic cancer research." The journal's format consists of solicited editorials, full articles, short reports including negative phase II trials, special articles reviewing a specific field, reviews and commentaries, and a section entitled "Arena" for opinionated contributions. Methodologic guidelines for reporting clinical trials are explicitly given in
Medizinische Kolloidlehre
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A PHYSICIAN'S PERSONAL HOBBIES AND PRESCRIPTIONS.
Journal: JAMA (1890)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Conjunctival Icterus
Authors: John J. Kuiper
Journal: Annals of Internal Medicine (2001)

Letters20 February 2001Conjunctival IcterusJohn J. Kuiper, MDJohn J. Kuiper, MDUniversity of California, Los Angeles, School of Medicine; Los Angeles, CA 90095-1736 (Kuiper)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-134-4-200102200-00029 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Medical students learn that scleral icterus is an important and often early sign of hyperbilirubinemia. Yet, in each of the eight editions (1892 to 1916) of the classic textbook of medicine that he authored, William Osler defined icterus as yellow "tinting of the skin and conjunctivae." The first six editions (1927 to 1943) of Cecil's Textbook of Medicinelocalize the initial appearance of yellow pigmentation in jaundice to the conjunctiva. In the mid-1940s, sclera displaced the conjunctiva as the site of localization of ocular icterus in textbooks (1, 2)—on the basis of studies published a decade earlier in ...References1. Christian HA. 15th ed The Principles and Practice of Medicine, Originally Written by Sir William Osler. New York: Appleton-Century; 1944:730. Google Scholar2. Cecil RL. A Textbook of Medicine. 7th ed. Philadelphia: Saunders; 1947:845. Google Scholar3. With TK. The pathogenesis and different forms of jaundice. Acta Med Scand. 1947;128:25-41. CrossrefMedlineGoogle Scholar4. Sherlock S. Diseases of the Liver and Biliary System. Oxford: Blackwell; 1955:17. Google Scholar Author, Article, and Disclosure InformationAffiliations: University of California, Los Angeles, School of Medicine; Los Angeles, CA 90095-1736 (Kuiper) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byGastrointestinal and Nutritional DisordersPediatric liver diseases and ocular changes: What hepatologists and ophthalmologists should know and share with each otherAdult Coats' Disease, Dubin-Johnson Syndrome, and the Search for Targeted TherapiesPeriocular, periorbital, and orbital pathology in liver diseaseClinical examination: EyesDiagnosing Jaundice by Eye—Outpatient Assessment of Conjunctival Icterus in the NewbornScreening neonatal jaundice based on the sclera color of the eye using digital photographyBilirubin Concentrations in Jaundiced Neonates with Conjunctival IcterusUnilateral conjunctival icterus and no 'glass eye'Xanthoderma: A clinical review 20 February 2001Volume 134, Issue 4Page: 345-346KeywordsAttentionAutopsyBilirubinMucous membranes ePublished: 20 February 2001 Issue Published: 20 February 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Audit: aiming high.
Journal: BMJ (1981)

human epidermis, and may form hapten-protein carrier complexes that can behave as inmunogens.Alternatively, the basal cell antibodies might be formed in response to death and breakdown of basal cells as a result of the accumulation of the drug or its derivative.Thus the deposition of immunoglobulin and complement in drug-induced bullous eruptions at sites identical with those in the classical bullous dermatoses should stimulate the investigator to a closer look for the initial site and cause of metabolic or immunological disturbance that leads to the formation of blisters.We may hope that the drug-induced mimicry will serve as an experimental model.Moreover, drug ingestion is an important triggering factor that must be considered by the clinical dermatologist faced with patients presenting with bullous eruptions, especially if these are atypical.
DOMESTIC CORRESPONDENCE.
Authors: E. J. Doering
Journal: JAMA (1893)

<h3>To the Editor of the Journal of the American Medical Association:</h3><h3>Sir:</h3> —Belonging to those who are opposed to any revision of the Code, I send you the following remarks addressed to the Chicago Practitioner's Club at a recent meeting when this matter was discussed: In this country, where liberty is confounded with unbridled license, where justice is so often an article of merchandise, where statesmanship is supplanted by political trickery, where science is used as a cloak to cover ignorance, where, in short, quackery, humbuggery and criminality flourish like vegetation in the tropics, in such a land there is need for a standard around which honorable men gather and by the strength of union elevate their calling to a higher plane, for their own personal good and for the benefit of the generation to follow. For this reason, gentlemen. I am a firm believer first, last and all the
The Fetus Becomes a Patient
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Radon and Lung Cancer Risk: Taking Stock at the Millenium
Authors: Jonathan M. Samet, George R. Eradze
Journal: Environmental Health Perspectives (2000)

Radon is a well-established human carcinogen for which extensive data are available, extending into the range of exposures experienced by the general population.Mounting epidemiologic evidence on radon and lung cancer risk, now available from more than 20 different studies of underground miners and complementary laboratory findings, indicates that risks are linear in exposure without threshold.Radon is also a ubiquitous indoor air pollutant in homes, and risk projections imply that radon is the second leading cause of lung cancer after smoking.Recommended control strategies in the United States and other countries, which include testing of most homes and mitigation of those exceeding guideline levels, have been controversial.Further research is needed, drawing on molecular and cellular approaches and continuing the follow-up of the underground miner cohorts, and scientists should work toward constructing mechanistically based models that combine epidemiologic and experimental data to yield risk estimates with enhanced certainty.
Highlights
Journal: JAMA Oncology (2019)

MSI-H, dMMR, and Management of Prostate Cancer 471In this case series, Abida and colleagues prospectively evaluated prostate tumors for microsatellite instability-high (MSI-H) or mismatch repair-deficient (dMMR) biomarkers to assess the use of immune checkpoint blockade in patients with MSI-H or dMMR disease.Results showed that although the MSI-H/dMMR molecular phenotype is uncommon, there is potential for durable responses to immune checkpoint blockade.Reichert et al provide an Invited Commentary.
Is 'male menopause' real or just an excuse?
Authors: A. A. Skolnick
Journal: JAMA (1992)

CASE WESTERN RESERVE University Hospitals' comprehensive (MacDonald) women's facility and School of Medicine in Cleveland, Ohio, are establishing a "climacteric gynecology" gellowship program. In announcing the program this fall, University Hospitals of Cleveland predicted that more than 20 million women in this country will reach menopausal age by the turn of the century. Fellowship training will focus on managing menopausal changes, including hormone replacement, and "menopause-related Wulf H. Utian, MBBCh, PhD, president, North American Menopause Society, and president-elect, International Menopause Society, is director, Department of Obstetrics and Gynecology, University MacDonald; professor and chair, Department of Reproductive Biology, Case Western Reserve University School of Medicine; and director, Cleveland Menopause Clinic. (Please see preceding articles.) Fellowship funding is through a grant from Wyeth-Ayerst Laboratories, Philadelphia, Pa.
P156 Efficacy, safety and tolerability of once-daily tiotropium respimat® add-on therapy in children with moderate symptomatic asthma
Journal: Thorax (2016)

AbstractO Schmidt has received research grants from Boehringer Ingelheim; E Hamelmann has received research grants and other fees from Boehringer Ingelheim and non-financial support from Boehringer Ingelheim; C Vogelberg has participated in an advisory board for Boehringer Ingelheim; I Laki has nothing to disclose; G El Azzi is an employee of Boehringer Ingelheim; M Engel is an employee of Boehringer Ingelheim; P Moroni-Zentgraf is an employee of Boehringer Ingelheim; H Finnigan is an employee of Boehringer Ingelheim; M Vandewalker has received research grants and personal fees from Boehringer Ingelheim.
Popliteal vein aneurysm with recurrent pulmonary thromboemboli
Authors: J. R. Dahl
Journal: JAMA (1976)

PULMONARY thromboembolism has been the subject of excellent reviews.<sup>1-3</sup>In none of these, however, could we find mention of peripheral venous aneurysm as an underlying cause of this disorder. We report such a case. <h3>Report of a Case</h3> A 59-year-old housewife was brought to the emergency room because of a sudden onset of severe pain in her left leg, which was preceded by dyspnea of two days' duration. She appeared lethargic and cyanotic. Her blood pressure was 140/90 mm Hg, her pulse rate was 120 beats per minute with frequent premature ventricular contractions, and her respirations were 16/min. Her left leg was pallid, cool, and pulseless beyond the femoral level. Although a popliteal artery embolus was diagnosed immediately, embolectomy was deferred until her cardiopulmonary status had been further clarified and stabilized. On admission to the ward, her hematocrit reading was 41% and her leukocyte count was 11,300/cu mm, with
Abstract SY28-03: Extending the paradigm of hormonal dependency of cancer to account for effects of lifestyle on risk and prognosis
Authors: Michael N. Pollak
Journal: Cancer Research (2019)

Abstract Cancer behavior is determined by cancer metabolism. Abnormalities in cancer cell metabolism are determined in part by intrinsic or autonomous characteristics of each cancer cell, which relate to in part to genetic alterations in oncogenes and cancer suppressor genes, and in part to host effects, which are mediated in large part by hormones and growth factors. Dietary and lifestyle factors that influence cancer risk or cancer prognosis influence levels of hormones such as insulin. We now recognize that these hormones influence the behavior of a subset of common cancers. Attempts to treat cancer by altering the hormonal milieu related to gonadal steroids have led to many widely used treatments for cancer of the breast and prostate, but it remains uncertain if this paradigm can be extended to lifestyle and nutritionally regulated hormones such as insulin, which have been found to be growth-stimulatory in certain preclinical models. We will review these concepts, including recent laboratory and clinical data related to metformin, an anti-diabetic drug under study for possible anti-neoplastic activity. Citation Format: Michael N. Pollak. Extending the paradigm of hormonal dependency of cancer to account for effects of lifestyle on risk and prognosis [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr SY28-03.
IFP News Section
Authors: Cornelis G. Kooiman, Sonja van Rees Vellinga, Philip Spinhoven, Nel Draijer, Rutger W. Trijsburg, Harry G.M. Rooijmans, Luis Gonçalves Sobrinho, Graeme J. Taylor, R. Michael Bagby, Nicoletta Sonino, Cecilia Navarrini, Chiara Ruini, Fedra Ottolini, Agostino Paoletta, Francesco Fallo, Marco Boscaro, Giovanni A. Fava, Piero Porcelli, Valeria Affatati, Antonello Bellomo, Massimo De Carne, Orlando Todarello, Graeme J. Taylor, Peter Kjær Graugaard, Kjersti Holgersen, Arnstein Finset, Michael Rufer, Iver Hand, Anne Braatz, Heike Alsleben, Susanne Fricke, Helmut Peter, Hans Joergen Grabe, Bertram Möller, Carsten Willert, Carsten Spitzer, Tim Rizos, Harald Juergen Freyberger, S. Fabbri
Journal: Psychotherapy and Psychosomatics (2004)
Unconscious on a corner...
Authors: D. Hilfiker
Journal: JAMA (1987)

THE POLICE brought Mr W. to the emergency room. They had found him unconscious on a corner in Washington, DC, one more drunk littering the city, disturbing our view. Fiftytwo years old, black, dressed in rags, homeless, he was no different from the countless other tragedies that find their way to the ER. But Mr W. was not drunk. His jaw had previously been broken and—at another emergency room—wired shut to heal, whereupon he had been discharged back to the streets. He couldn't eat or drink enough to keep himself going, and so it was that the police found him, severely dehydrated, unconscious, close to death. Mr W. was initially rehydrated with intravenous solutions, but his condition deteriorated, and he was readmitted to the intensive care unit. Tests were ordered, examinations repeated, consults held. At last it was clear: Mr W. had the syndrome of inappropriate antidiuretic hormone secretion with
Effects of Promoters on N-Butyl-N-(4-hydroxybutyl)nitrosamine-Induced Urinary Bladder Carcinogenesis in the Rat
Authors: Nobuyuki Ito, Shoji Fukushima, Tomoyuki Shirai, Keisuke Nakanishi
Journal: Environmental Health Perspectives (1983)

It has been shown that the occurrence of the preneoplastic lesion, papillary or nodular hyperplasia (PN hyperplasia) in rat urinary bladder induced by carcinogens is correlated with that of cancer. Therefore, the promoting effects of chemicals in two-stage bladder carcinogenesis were judged by measuring their ability to induce PN hyperplasia in rats. Male rats were given N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) for 4 weeks and then one of 16 test chemicals for 32 to 34 weeks. Saccharin, ascorbate, DL-tryptophan, allopurinol, and diphenyl promoted development of PN hyperplasia. The dose-response of the promoters were examined in both sexes of rats by administration of saccharin at doses of 0.04, 0.2, 1.0 and 5.0% for 32 weeks after BBN treatment. The occurrence of PN hyperplasia was significantly increased in the group given 5% saccharin. Dose-response curves showed enhanced hyperplastic responses in both sexes given 0.2 to 5% saccharin. The organ specificities of promoters were studied in rats initiated with BBN or 2-acetylamino-fluorene (2-AAF) followed by phenobarbital or saccharin for 32 weeks. Phenobarbital greatly enhanced hepatocarcinogenesis. Saccharin significantly enhanced the occurrence of both BBN-induced and 2-AAF-induced PN hyperplasia. However, there was no effect of phenobarbital on the urinary bladder or of saccharin on the liver. The rats showed a strain difference in susceptibility of the urinary bladder to saccharin; ACI rats were most susceptible and Sprague Dawley rats were most resistant to saccharin. The membrane potential of superficial epithelial cells in the urinary bladder of rats treated with saccharin was measured with an intracellular microelectrode and found to be higher than that of controls.
RATIONAL DIETARY ADVICE
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PCB Levels in Breast Milk: Data from the UNEP/WHO Pilot Project on Biological Monitoring and Some Other Recent Studies
Authors: Stuart A. Slorach, Reggie Vaz
Journal: Environmental Health Perspectives (1985)

The levels of polychlorinated biphenyls (PCBs) in human milk provide an index of exposure of the mother to these compounds and enable the intake by the breast-fed child to be estimated. For valid comparisons between different studies, concentrations should be expressed on a milk fat basis. In a recently completed UNEP/WHO pilot project on monitoring of organochlorine compounds in human milk in ten countries, great emphasis was placed on analytical quality assurance. To obtain comparable data, a common procedure, that of Sawyer, was adopted for quantitation of PCBs, using Aroclor 1260 as standard. In addition, certain criteria (e.g., age and parity) were established for selection of the mothers to be sampled. In contrast to the situation with p,p'-DDT and p,p'-DDE, the levels of PCBs in human milk fat were higher in the European countries and Japan than in China, India and Mexico. In fact, PCBs were not detected in human milk in the latter three countries. Although PCBs were detected in some samples in the USA, the median level was below the limit of detection of the method used there (1 mg/kg fat). The median PCB levels reported from Belgium, Israel, Japan and Yugoslavia were 0.81, 0.45, 0.35 and 0.63 mg/kg fat, respectively. Higher median levels were reported from Sweden and the Federal Republic of Germany (0.97 and 2.1 mg/kg fat, respectively). The German samples were not analyzed by the Sawyer method.
Journal Correction
Journal: Journal of Clinical Oncology (2010)

contained an error.In the Patients and Methods section, under Treatment and Follow-Up, Arm A, the dose for bleomycin was given as 30,000 U, whereas it should have been 30,000 IU (30 mg), as follows:"One cycle of BEP chemotherapy was administered using following dosages: cisplatin 20 mg/m 2 , days 1 to 5, 60-minute infusion; etoposide 100 mg/m 2 , days 1 to 5, 60-minute infusion; bleomycin 30,000 IU (30 mg), days 1, 8, and 15, bolus infusion."The online version has been corrected in departure from the print.
Selective ET A receptor antagonism reduces neointimal hyperplasia in a porcine coronary stent model
Authors: C.J. McKenna, S.E. Burke, T.J. Opgenorth, R.J. Padley, L.D.J. Camrud, A.R. Camrud, P.J. Carlson, A. Lerman, D.R. Holmes, R.S. Schwartz
Journal: Journal of the American College of Cardiology (1998)