tbuckley/cabot-search huggingface dataset:
INJURIES OF THE FEET
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction to: Imported falciparum malaria in adults: host- and parasite-related factors associated with severity. The French prospective multicenter PALUREA cohort study
Authors: Fabrice Bruneel, Florence Tubach, Jean-Paul Mira, Sandrine Houze, Sebastien Gibot, Marie-Genevieve Huisse, Bruno Megarbane, Christophe Choquet, Philippe Corne, Eric Peytel, Daniel Villers, Christophe Camus, Olivier Bouchaud, Eric Caumes, Pierre-Marie Girard, Fabrice Simon, Antoine Kalloumeh, Carine Roy, Remy Durand, Jacques Le Bras, Sophie Matheron, Michel Wolff
Journal: Intensive Care Medicine (2017)
Pregnanediol Excretion
Authors: A. M. Hain, E. M. Robertson
Journal: BMJ (1939)

BRITISHminutes, the patient remaining asleep during the rest of the operation.This group accounted for 2{ per cent. of the cases, or, if the upper abdomen be excluded, 3 per cent.3. There is a small proportion of cases-0.5 per cent.-inwhich, in spite of apparently perfect technique, a spinal anaes- thetic has no effect whatever: full sensation is present, there is no relaxation and no fall in blood pressure.In the absence of technical faults one is forced to fall back on the rather unsatisfying explanation of a "rachi-resistant " patient.This small number of cases comprised the only complete failures, and are ones that require supplementary full general anaes- thesia.
DRES-09. MECHANISMS OF RESISTANCE TO EGFR INHIBITION REVEAL METABOLIC VULNERABILITIES IN HUMAN GBM
Authors: Andrew McKinney, Olle Lindberg, Kan Lu, Erin Simonds, Theo Nicolaides, William Yong, Albert Lai, Monika Hegi, William Weiss, Joanna Phillips
Journal: Neuro-Oncology (2016)

Therapeutic targeting of EGFR signaling in GBM has had largely disappointing results in the clinic. We sought to identify cell vulnerabilities that could be targeted in combination with EGFR. Using a murine model for GBM, primary patient derived xenografts (PDXs), and human tumors we identify altered lipid metabolism and intratumoral heterogeneity as important mechanisms of resistance to EGFR inhibition. In murine tumor progenitor cells (TPCs) driven by oncogenic EGFR, inhibition of EGFR selected for a tumor cell subpopulation with a highly invasive phenotype. This drug resistant subpopulation expressed several markers associated with chemoresistance including increased expression of enzymes responsible for detoxification of lipid peroxidation products. As strong oncogenic signaling is associated with increased de novo lipogenesis, we hypothesized EGFR inhibition may increase lipid peroxidation. Indeed, upon EGFR inhibition we observed increased generation of toxic lipid peroxidation products. Cell subpopulations with increased metabolism of these toxic products demonstrated increased drug resistance and a pro-invasive phenotype upon EGFR inhibition. Examination of 92 human GBM and 9 PDX lines revealed robust expression of enzymes able to detoxify these lipid peroxidation products in a significant subset of tumors. In a PDX with EGFR signaling, EGFR inhibition increased enzyme expression and increased tumor cell invasion in an enzyme-dependent manner. Interestingly, a PDX with high endogenous enzyme expression was highly sensitive to enzyme inhibition as demonstrated by decreased tumor cell invasion and decreased cell survival. These data identify expression of enzymes that detoxify lipid peroxidation products as a mechanism of resistance to EGFR inhibition and reveal a potential metabolic vulnerability to exploit therapeutically.
Comparative Pharmacokinetics of Unbound Paclitaxel During 1- and 3-Hour Infusions
Authors: Hans Gelderblom, Klaus Mross, Albert J. ten Tije, Dirk Behringer, Stephan Mielke, Desirée M. van Zomeren, Jaap Verweij, Alex Sparreboom
Journal: Journal of Clinical Oncology (2002)

PURPOSE: The paclitaxel vehicle Cremophor EL (CrEL) profoundly influences the cellular distribution of paclitaxel in human blood in vitro by a concentration-dependent decrease of the unbound drug fraction. Because CrEL clearance increases by extending the infusion duration from 3 to 24 hours, we hypothesized that exposure to unbound paclitaxel might also be schedule-dependent. PATIENTS AND METHODS: CrEL and unbound paclitaxel pharmacokinetics were prospectively analyzed in 29 patients with advanced solid tumors treated with paclitaxel 100 mg/m 2 given as a 1-hour (n = 15) or 3-hour (n = 14) intravenous infusion. RESULTS: The systemic exposure (area under the curve [AUC]) to CrEL was significantly higher with the 1-hour as compared with the 3-hour schedule (80.2 ± 24.2 v 48.5 ± 24.1 μL·h/mL; P = .002). In contrast, the AUC of unbound paclitaxel was substantially reduced after the 1-hour infusion (0.50 ± 0.10 v 0.62 ± 0.12 μmol/L·h; P = .009). Similarly, clearance and volume of distribution were significantly dependent on infusion duration (P &lt; .005). A trend was observed toward more severe hematologic toxicity with the 3-hour schedule (P = .053), consistent with increased exposure to unbound drug. CONCLUSION: Overall, these findings explain, at least in part, previous observations that short-infusion schedules of paclitaxel lack significant myelotoxicity, whereas potentially CrEL-related side effects, including peripheral neuropathy, are augmented.
Proceedings of the British Thoracic Society, 1988 winter meeting. 8 and 9 December, London.
Authors: M Finnegan, D Jayne, S Neill, N Munro, D Currie, M Greenstone, W Hendry, P Cole, J Lapa, E Silva, D Guerreiro, B Noble, L Poulter, Cole Host, D Burnett, S Hill, P Black, R Fuller, A Knox, J Clark
Journal: Thorax (1989)

Cambridge Vasculitis complicating CF has rarely been reported (
The service team in a coordinated home care program
Authors: E. Reese
Journal: JAMA (1968)

<h3>To the Editor:—</h3> We are in general agreement with the answer of your consultant regarding the handling of a 54-year-old housewife having a weekly reactive venereal disease research laboratory (VDRL) slide test and a reactive fluorescent treponemal antibody-absorption procedure with serum (FTA-ABS) test (<b>203</b>: 996, 1968). Evidence available to me indicates that in the serodiagnosis of syphilis the FTA-ABS test is as specific as the<i>Treponema pallidum</i>immobilization (TPI) test, yet more sensitive. Of course, patients having yaws or pinta, or other treponematoses closley related to syphilis, may also be expected to react; but these diseases would not usually be considered in the United States unless the patient has lived or traveled in countries where the diseases are endemic. A subsequent correspondent (<b>204</b>: 833, 1968) agreed with your consultant's emphasis on the possibility or probability of syphilis, but also urged that efforts be made to identify factors which might be
In This Issue
Journal: American Journal of Psychiatry (2014)

Alarcón et al. (p.506) highlight the importance of immigration and culture in the case of a depressed young man from Colombia, who searched for help from a number of professionals, including a traditional healer and a non-Latino psychiatrist, and then found support from a group of Latino young adults discussing "what it means to be a Latino in the U.S." The authors suggest the use of the Cultural Formulation Interview in DSM-5 to elicit information about how patients' cultural background may have influenced their understanding of their illness and the presenting symptoms, such as somatization.Ethnic background is also a consideration in pharmacologic treatment, as CYP-450 genotype can influence drug response and side effects.Fairburn and Patel (p.495) suggest possible remedies for the global shortage of psychological treatments.Options for increasing the number of therapists include Internet-based training and training of less-qualified people.Expanding treatment on the scale needed, however, may require creation of widely available Internet self-help programs.
A Voluntary National Examining Board.
Authors: William L. Rodman
Journal: JAMA (1902)

Philadelphia, May 31, 1902. <h3>To the Editor:</h3> —There being a little misconception as to the exact purpose of a Voluntary National Board of Examiners, which I advocated at the April meeting of the Committee on National Legislation representing the American Medical Association, in the city of Washington, I will explain the plan more fully. Some have thought that such a board could only benefit recent graduates, and that it fails to give relief to practitioners. Good as it is for the recent graduates, it is much better and was really more intended to aid and benefit practitioners, who from ill health, on account of consultation practice, professorial calls, or any cause whatsoever, may wish a license in another state. My own experience upon removal to Pennsylvania has caused me to work at the problem of reciprocity for the past three years, and I have constantly agitated the subject as a
Secretory Otitis Media: The Cantekin Affair
Authors: Irwin Tessman
Journal: JAMA (1992)

<h3>To the Editor.</h3> —It was reassuring to see in Dr Rennie's long review of "The Cantekin Affair"<sup>1</sup>the statement that editors "make great efforts to judge manuscripts on the quality of research rather than the status of the researcher." It is surely a fundamental principle that authority is irrelevant; the science must always speak for itself. But are you consistent? Why do medical journals publish the academic degrees of its authors, a policy that practically no other type of scientific journal would tolerate? Rennie presents us with a telling quote from Cantekin's disapproving bosses: "Indeed, Dr Cantekin is not a physician." I wonder if it is that type of pathetic snobbery that motivates the listing of academic degrees.
Pernicious anemia, 18q deletion syndrome, and IgA deficiency
Authors: R. B. Stricker
Journal: JAMA (1982)

THE CHROMOSOME 18q deletion (18q—) syndrome is a well-described clinical entity characterized by mental retardation, short stature, and a variety of developmental abnormalities.<sup>1,2</sup>The syndrome often includes selective IgA deficiency.<sup>3</sup>Although IgA deficiency has been associated with a wide range of autoimmune disorders,<sup>4,5</sup>only a few patients with 18q— and IgA deficiency have exhibited autoimmune phenomena.<sup>6</sup> We report a case of 18q— syndrome with IgA deficiency complicated by a polyglandular autoimmune disorder composed of pernicious anemia, hypothyroidism, and hypoparathyroidism. <h3>Report of a Case</h3> A 21-year-old woman experienced the sudden onset of pallor and fatigue and was hospitalized because of severe anemia. She was the product of a normal gestation and delivery, but her growth and development were strikingly slowed. At the age of 9 years, the diagnosis of 18q— syndrome was made, with the additional finding of a ring 18p chromosome. The IgA level was 8
Tympanic membrane vs rectal temperature measurement in marathon runners
Authors: W. W. Briner
Journal: JAMA (1996)

<h3>To the Editor.</h3> —Exertional heat illness may encompass a variety of syndromes, including heat cramps, heat exhaustion, and heat stroke. All of these are more likely to occur in conditions of high heat and humidity such as may prevail at the Summer Olympic Games in Atlanta, Ga. Athletes with heat illness may sustain severe consequences, including acute renal failure and fatality. Therefore, it is essential that body temperature be assessed accurately in those who may be at risk. Endurance events such as the marathon and triathlon place athletes at greatest risk.<sup>1</sup> Most authors have recommended monitoring rectal temperatures as the best measure of core temperature in the setting of exertional thermal illness. Core temperature reflects the clinical status of these patients. Higher temperatures (especially those &gt;40.6°C [&gt;105°F]) imply heat stroke and portend a poorer prognosis.<sup>1</sup>Rectal temperature has been demonstrated to reflect core temperature measured at the pulmonary
Drug abuse in anesthesia training programs. A survey: 1970 through 1980
Authors: C. F. Ward
Journal: JAMA (1983)

Experience at our institution with drug dependence among anesthesia residents, coupled with a lack of published data, prompted us to survey US anesthesia training programs. Two hundred eighty-nine programs were surveyed, 247 (85.5%) responded, and 184 (74%) of these programs had at least one suspected incident of drug dependence to report. Three hundred thirty-four confirmed persons were reported, including a substantial number of instructors. Meperidine and fentanyl were the most frequently mentioned drugs. Behavior changes were frequently noted by staff personnel, and in general such changes led directly to detection. After confirmation of abuse, the majority of impaired anesthetists were referred for psychiatric care, with few in need of actual detoxification. Detailed follow-up was available for about 40% of the total; 71 persons were offered a return to their original place of employment, while 30 persons died of drug overdose. Chemical impairment may be more common than usually thought in anesthesia, perhaps in part because of drug availability. (<i>JAMA</i>1983;250:922-925)
Safe exclusion of pulmonary embolism using the Wells rule and qualitative D-dimer testing in primary care: prospective cohort study
Journal: BMJ (2012)

Safe exclusion of pulmonary embolism using the Wells rule and qualitative D-dimer testing in primary care: prospective cohort studyThe authors of this Research paper would like to point out that a calculation error resulted in an inaccuracy in the figure, which shows the flow of participants through the study (BMJ 2012;345:e6564, doi:10
Toward less hazardous cigarettes. Current advances
Authors: G. B. Gori
Journal: JAMA (1978)

Critical levels of selected cigarette smoke constituents have been expressed in terms of maximum numbers of pre-1960 cigarettes that a smoker may consume daily without increasing his mortality risk substantially above that of a nonsmoker. This could still imply an important risk, although it may be difficult to detect. We relate these levels to the yields of 27 current low tar and nicotine commercial cigarettes, as measured at the Oak Ridge National Laboratory. In addition, the yields of these selected constituents concomitant with the yield of 1 mg of nicotine are provided as a guide for the smoker who titrates or adjusts his smoking pattern to accommodate a fixed daily intake of nicotine. (<i>JAMA</i>240:1255-1259, 1978)
PATHOLOGIC ASEPSIS?
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Inhibition of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) messenger RNA (mRNA) expression in HL-60 leukemia cells by pentoxifylline and dexamethasone: dissociation of acivicin- induced TNF-alpha and IL-1 beta mRNA expression from acivicin-induced monocytoid differentiation
Authors: JB Weinberg, SN Mason, TS Wortham
Journal: Blood (1992)
Intrinsic Factor
Authors: Victor Herbert, William B. Castle
Journal: New England Journal of Medicine (1964)

THE demonstration,1 in 1929, that normal human gastric juice contained an "intrinsic factor" that, given simultaneously with an "extrinsic factor" present in beef muscle, caused an erythropoietic response in pernicious anemia initiated a laborious form of clinical investigation attractive to few. When, in 1948, it was shown2 that the active principle of purified liver extracts, vitamin B12, was also the so-called extrinsic factor, interest quickened. In 1952, after the preparation3 of vitamin B12 labeled with radioactive cobalt (Co60), Heinle and his associates4 demonstrated that in pernicious anemia, intrinsic factor enhanced the assimilation of the radioactive tracer, . . .
The correlation of breakpoint cluster region rearrangement and p210 phl/abl expression with morphological analysis of Ph-negative chronic myeloid leukemia and other myeloproliferative diseases
Authors: LM Wiedemann, KK Karhi, MK Shivji, SI Rayter, SM Pegram, G Dowden, D Bevan, A Will, DA Galton, LC Chan
Journal: Blood (1988)
Book Review Diseases of the Urethra and Penis . By E. D'Arcy McCrea, M.D., M.Ch. (Dub.), F.R.C.S. (Ireland), F.R.C.S. (Eng.). 8°, cloth, 306 pp., with 181 illustrations. Baltimore: Williams and Wilkins Company, 1940. $6.50.
Journal: New England Journal of Medicine (1941)
Food Allergy
Authors: Rebecca H. Buckley
Journal: JAMA (1982)

FOOD ALLERGY is widely perceived by the public as a major health problem. Although the true incidence of food allergy is unknown, it is probably much less common than thought. Its incidence among children has been variously estimated from 0.3% to 7.5%, and the incidence decreases with age. Acute allergic reactions to foods which are clearly IgE mediated can, however, develop in adults who previously tolerated foods with impunity. Clinically, food-induced reactions of the immediate hypersensitivity type are well documented and include urticaria, angioedema, and anaphylaxis. Reactions to foods mediated through cytotoxic, antigen-antibody-complex and delayed hypersensitivity mechanisms remain to be clearly demonstrated except in gluten-induced enteropathy, where immunoglobulin and complement deposition has been noted. <h3>CLINICAL FEATURES</h3> Immunologically mediated reactions to foods are expressed clinically by a diversity of signs and symptoms from abdominal pain to generalized anaphylaxis. These clinical expressions of food allergy are influenced by factors including the age
Abstract 1622: High salt Intake Superimposed On Left Ventricular Hypertrophy Activates Brain Enac And Leads To Sympathetic Hyperactivation And Ventricular Dysfunction
Authors: Koji Ito, Yoshitaka Hirooka, Kenji Sunagawa
Journal: Circulation (2008)

Background: High-salt intake often predisposes patients with left ventricular hypertrophy (LVH) to congestive heart failure. We hypothesized that high-salt intake superimposed on LVH activates brain epithelial Na channels (ENaC) and leads to sympathetic hyperactivation and LV dysfunction. Methods and Results: We used ICR mice and applied aortic banding (AB) to create LVH. Sham-operated mice served as control. Four weeks after AB, 24-h urinary norepinephrine excretion (U-NE) tended to increase rather than that in control (481±46 vs 354±42, n=10, p=0.09). AB hypertrophied LV wall thickness (WT) (2.2±0.6 vs 1.8±0.6 mm, n=8, p&lt;0.05) without changing fractional shortening (%FS). We then fed the AB mice a high salt (8%) (AB-H) or regular salt (AB-R) diet for additional 4 weeks. AB-H depressed LV function (%FS: 27±2 vs 37±1%, n=8, p&lt;0.05) and hypertrophied LVWT more than those in AB-R (WT: 2.8±0.5 vs 2.5±0.3 mm, n=8, p&lt;0.05). U-NE was higher in AB-H than in AB-R (758±86 vs 459±35 ng/day, n=10, p&lt;0.05). To examine the role of brain ENaC, we intracerebroventriculary (ICV) infused ENaC blocker (benzamil, 0.11μg/hr by osmotic pump) in AB-H for 4weeks. ENaC blocker decreased U-NE (567±35 vs 758±86 ng/day, n=10, p&lt;0.05) and improved depressed LV function (%FS: 39±1 vs 28±3 %, n=10, p&lt;0.05). To confirm the role of central Na in sympathetic hyperactivation and LV dysfunction, we administered, in AB with regular salt diet, high-Na (0.2 M) cerebrospinal fluid ICV (Na-ICV) (0.25μl/hr) for 2 weeks. Na-ICV significantly increased U-NE and deteriorates LV function (U-NE:987±103 ng/day, %FS: 31±1 %n=6) Conclusions: These results suggested that high-salt intake in the presence of LVH activates brain ENaC and leads to sympathetic hyperactivation and LV dysfunction.
Toward less hazardous cigarettes
Authors: K. E. Warner
Journal: JAMA (1979)

<h3>To the Editor.—</h3> In a recent issue ofThe Journal, Gio Gori, PhD, and Cornelius Lynch, PhD, report on "[c]ritical levels of selected cigarette smoke constituents... expressed in terms of pre-1960 cigarettes that a smoker may consume without increasing his mortality risk substantially above that of a nonsmoker." These critical levels are translated into equivalent numbers of present-day low tar and nicotine cigarettes in order to provide information to help "the smoker to wean himself to progressively less hazardous cigarettes." While the authors' motivation is beyond reproach, their analysis is predicated on some highly questionable assumptions that, if wrong, challenge the validity of their conclusion. Here I will note only two such assumptions. First, the vast majority of current regular (eg, pack-a-day) smokers inhale. Hence, for a meaningful comparison between present-day low tar and nicotine cigarette smoking and the pre-1960 ingestion of smoke constituents, the latter must be associated with