tbuckley/cabot-search huggingface dataset:
Total serum IgD is increased in atopic subjects
Authors: Z. Peng, R. Fisher, N. Franklin Adkinson
Journal: Allergy (1991)

We have developed a sandwich‐type ELISA system for measuring total IgD levels in the serum of atopics and non‐atopic controls. In this ELISA system, affinity purified goat anti‐human IgD was used for capture. Results were superior to those obtained with monoclonal anti‐human IgD antibody. No cross‐reactivity could be demonstrated to IgG, IgM, IgA or IgE. The assay showed minimal non‐specific binding even with initial serum dilutions of 1:2. The results obtained were reproducible among replicates (Mean CV SEM = 0.03 0.002; n = 251), between dilutions (CV = 0.08 0.006; n = 108), and between assays (CV = 0.05 0.12; n = 5). We used routine radioimmunoassay for measuring total serum IgE. Using these assays total serum IgD and IgE levels were measured in 75 atopic patients and 33 normal subjects. None of the atopics had recent immunotherapy. As expected, the geometric mean serum IgE in atopics (373 ng/ml) was significantly higher than that in normal subjects (49 ngiml) ( P &lt; 0.01). However, geometric mean serum IgD was also significantly higher in atopics (20.3 μg/ml) than that in normal subjects (8.4 μg/ml) ( P &lt; 0.02). In both atopic and normal groups, mean serum IgD level did not differ significantly on the bases of age, sex or asthmatic status. Furthermore, total serum IgD was not significantly correlated with total serum IgE (r = 0.14; P = 0.14; n = 108), indicating that immunoregulatory control of the basal levels of the two isotypes is not linked. In a subset of more thoroughly studied atopic patients, total serum IgD but not serum IgE was correlated with D 2 O‐induced basophil histamine release (r = 0.34: P &lt; 0.05; n = 37). There was no correlationship of serum IgD or serum IgE to methacholine inhalation challenge, to spontaneous basophil histamine release or that induced by anti‐IgE, calcium ionophore, or a platelet‐derived histamine releasing factor (PD‐HRF). However, among poor responders to PD‐HRF, serum IgD was also correlated with PD‐HRF induced histamine release (r = 0.59; P &lt; 0.025; n = 21). Our preliminary results indicate that the role of IgD in atopic disorders deserves further investigation.
'Artificial Fat' Prevents Bed Sores
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dosage and Algorithm Updated
Authors: Job Hermans, Jolanda Luime, Duncan Meuffels
Journal: JAMA (2013)

vided the width of the estimated LR (95% CI) to express the uncertainty.Knowing this, a reader can decide whether the evidence supports using the findings or not.The Cochrane review 1 based their conclusions on 18 studies without creating summary measures.For the findings that were replicated on individual signs in our review, we calculated summary measures that suggest the well-known test of Hawkins, Neer, Gerber, and the empty can test are not of high diagnostic accuracy.In addition, in the online supplemental content for our review, we elaborated on verification bias and how it might affect the estimates of sensitivity, specificity, and the accompanying LRs.We showed that when verification bias exists in published studies, the findings conducted by specialists with a high positive LR ought to be the findings that a generalist tries to emulate because it is likely that a positive test will perform even better in a broader population.Based on the best available evidence, we recommend that generalist physicians develop proficiency in the 5 tests with the best LRs and the narrowest 95% confidence intervals.The results of these tests can be combined with the presented population prevalence of RCD.In the end, this supplies the generalist physician with practical means to estimate the posterior probability of disease without the necessity of using imaging for every patient.
The Menopause
Authors: Joseph Rogers
Journal: New England Journal of Medicine (1956)

DESPITE a voluminous literature concerning the menopause, there are misconceptions and confusion about the significance and the proper management of this period in woman's life. Discussion continues regarding which of the symptoms associated with the menopause are due to hypoestrogenism and which are due to psychogenic factors, although several excellent reviews have been presented.1 2 3 4 5 6 7 8 9 10 11 12 There is disagreement about the use of hormones in menopausal therapy. The nature of the advertising appearing in both medical and lay publications, the unfortunate practice of attributing any symptom arising in the middle-aged woman to the menopause and the misconceptions still passed from mother to . . .
<i>An Atlas of the Medulla and Midbrain.</i>By Florence R. Sabin. pp. 123; 7 colored plates, one black plate and 52 figures. (Baltimore: The Friedenwald Company, 1901.) Price $1.75
Authors: G. E. S.
Journal: American Journal of Psychiatry (1902)

the section should remain in each reagent.This alone makes the book of greatest possible value to the beginner of neurological histology'.As will be seen the methods given are the best of their kind and the ones most commonly used by students of the nervous system.
Cardiogenic Shock
Authors: Robert M. Califf, James R. Bengtson
Journal: New England Journal of Medicine (1994)

Major advances in the management of congestive heart failure1 and acute myocardial infarction2 have ushered in a new era of optimism about the prognosis of patients with these disorders. Cardiac failure with cardiogenic shock continues to be a frustrating clinical problem, however, because of persistent mortality rates of 30 to 90 percent and substantial morbidity among hospitalized patients3,4. The management of this condition requires a rapid, well-organized approach. Avoiding futile intervention that is unlikely to prolong life or give patients a reasonable chance of functional recovery is also increasingly important in this era of limited resources and public . . .
Prevalence of Overweight in Selected States— Behavioral Risk Factor Surveillance, 1986
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Survival analysis of patients undergoing dialysis
Authors: P. J. Held
Journal: JAMA (1987)

We analyzed the five-year survival of 4661 patients with end-stage renal disease whose first dialysis occurred in 1977. The analysis incorporated characteristics of patients and dialysis institutions. Results showed that mortality was positively correlated with patient age, initial conditions leading to renal failure, being male and white, open staffing, and the number of staff physicians. In addition, lower death rates were observed for patients treated in larger dialysis units and units that had been long-term reusers of dialyzers. Patients treated in for-profit and not-for-profit units appeared to have the same mortality, although patients treated in freestanding units had lower mortality. The direction of causation was not always clear in these results. (<i>JAMA</i>1987;257:645-650)
Multi institutional phase II trial of single agent regorafenib in refractory advanced biliary cancers.
Authors: Richard D. Kim, Andrew Stewart Poklepovic, Andrew B. Nixon, Dae Won Kim, Heloisa P. Soares, Jongphil Kim, Jun Min Zhou, Fatima Tariq, Natalie Burgess, Hanna Kelly Sanoff
Journal: Journal of Clinical Oncology (2018)

4082 Background: There is currently an unmet medical need for patients with advanced biliary cancer (BC) who have failed one prior gemcitabine based systemic therapy.Regorafenib is an oral multi-kinase inhibitor that targets both receptor tyrosine kinases (RTKs), as well as the tumor cell proliferation/survival signaling pathway kinases (RAS/RAF/MEK/ERK). Methods: Pts with histologically proven BC who progressed on at least one line of systemic therapy received regorafenib 160 mg daily 21 days on 7 days off in a 28 days cycle. The single arm design was used to access 6 month overall survival (OS) as a primary endpoint. The study tested the null hypothesis of ≤30% of OS at 6 month against the alternative of ≥50% of OS at 6 month (HR = 0.578 ). With one-sided α of 10% and 86% power, the experimental treatment was deemed to have good activity if ≥14 out of 32 evaluable patients (43.8%) survive 6 months or longer. The secondary objectives included median OS, RR and PFS. Results: Thirty nine pts received at least 1 dose of regorafenib of whom 32 pts were evaluable for efficacy. Twenty pts failed 1 line of therapy and 12 pts failed two lines of therapy. Median age was 62 (range: 27-88) years and the primary sites of tumor were intrahepatic cholangiocarcinoma (68.8%), extrahepatic (18.8%), and gallbladder (12.5%). Pts were considered evaluable for efficacy if patients received more than 1 cycle of regorafenib. Seven pts were not evaluable because one pt withdrew consent, 5 pts expired due to clinical progression within a month and 1 pt due to toxicity. For 32 evaluable pts, 6 month OS was 50.9% (95% CI: 32.1%-67.0%), 12 month OS was 35% (95% CI 16.2-53.7) and 18 month OS was 35% (95% CI 16.2-53.7). Median PFS was 3.7 months (95% CI: 2.3-5.5) and median OS was 9.9 months (95% CI: 3.7-20.1). PR was achieved in 2 (6.2%) pts, SD in 18 (56.2%) pts with DCR of 62.4%. The overall toxicity profile was as expected with grade 3/4 AE of 71.8%. The most common adverse events were fatigue (56.4%) and hypertension (53.8%). Dose modification was required in 49% of the patients. Plasma samples were collected in all pts with planned correlative studies underway. Conclusions: The primary endpoint was met in this study. Further randomized trials are warranted to confirm the efficacy Clinical trial information: NCT02115542.
Book Review Recent Advances in Medical Science: A study of their social and economic implications . A Rede Lecture delivered before the University of Cambridge, on April 28, 1939. By Sir Edward Mellanby, K.C.B., M.D., F.R.C.P., F.R.S., K.H.P. 12°, paper, 62 pp. Cambridge, England: At the University Press, 1939. $.75.
Journal: New England Journal of Medicine (1940)
Factors influencing primary cesarean rates
Authors: S. M. Taffel
Journal: JAMA (1994)

<h3>To the Editor.</h3> —The article by Dr Parrish and colleagues<sup>1</sup>stimulated us to reanalyze national primary cesarean rates. Parrish et al found that demographic changes (maternal age, parity, birth weight, and plurality) in the childbearing population from 1970 through 1990 accounted for a quarter of the rise in primary cesarean rates in Washington State. We replicated their analysis using national data for 1971 through 1991 (national data on plurality was not available for 1970) and found that changes in maternal age, parity, birth weight, and plurality considered simultaneously accounted for 21% of the rise in the national primary cesarean rate over this 20-year period (from 4.4% in 1971 to 15.9% in 1991) (the 1971 rate is based on unpublished data from the 1971 National Hospital Discharge Survey conducted by the National Center for Health Statistics; the 1991 rate is based on birth certificate data from the national vital registration
α5β1 integrin recycling promotes Arp2/3-independent cancer cell invasion via the formin FHOD3
Authors: Nikki Rosanna Paul, Jennifer Louise Allen, Anna Chapman, Maria Morlan-Mairal, Egor Zindy, Guillaume Jacquemet, Laura Fernandez del Ama, Nermina Ferizovic, David Green, Jonathan David Howe, Elisabeth Ehler, Adam Hurlstone, Patrick T. Caswell
Journal: The Journal of Experimental Medicine (2015)
Prolonged bleeding times and bleeding diathesis associated with moxalactam administration
Authors: M. R. Weitekamp
Journal: JAMA (1983)

A reversible bleeding diathesis associated with marked prolongation of the bleeding time was recognized in five patients receiving the new antibiotic moxalactam disodium (Moxam). Platelet dysfunction secondary to interference with adenosine diphosphate-induced aggregation has been demonstrated in vitro. Clinically important hemorrhage consequent to the use of this antibiotic may be more common than previously thought. (<i>JAMA</i>1983;249:69-71)
Abstract 1821: LINC00346 regulates c-Myc transcriptional activity through CTCF in pancreatic cancer
Authors: Wan-Xin Peng, Yin-Yuan Mo
Journal: Cancer Research (2019)

Abstract Pancreatic ductal adenocarcinoma (PDAC), a most challenging malignant disease, is estimated to become the second leading cause of cancer-related deaths in the United States between the year 2020 and 2030. Although the aberrant activation of KRAS has been demonstrated as the driving force of PDAC progression, the contribution of other molecules, especially long non-coding RNAs (lncRNAs), to PDAC progression remain largely unknown. In the present study, we interrogated the pancreatic adenocarcinoma dataset of the Cancer Genome Atlas (TCGA) consisting of 186 cases. Among 2,730 lncRNAs analyzed, LINC00346 revealed the highest alterations among these lncRNAs with 11% frequency at the RNA level. In addition, its upregulation was significantly associated with overall survival (OS) and disease-free survival (DFS), respectively. To determine the biological function of LINC00346 in pancreatic cancer, we next performed loss-of-function assay in pancreatic cancer cell lines MIA PaCa-2 and BxPC-3 by CRISPR/Cpf1 technology using dual gRNA approach. The results showed that knockout (KO) of LINC00346 impaired pancreatic cancer cell proliferation, tumorigenesis, migration and invasion ability, while these phenotypes were restored by LINC00346 re-expression in KO cells (i.e., rescue experiment). Mechanistically, LINC00346 functions as a positive regulator of c-Myc. Further characterizations demonstrated that LINC00346 transcriptionally activates c-Myc expression by interaction with CTCF. Together, these results suggest that LINC00346 contributes to PDAC pathogenesis by activating c-Myc, and thus, LINC00346 may serve as a potential target for pancreatic cancer therapy. Note: This abstract was not presented at the meeting. Citation Format: Wan-Xin Peng, Yin-Yuan Mo. LINC00346 regulates c-Myc transcriptional activity through CTCF in pancreatic cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1821.
Section on Materia Medica and Pharmacy.
Journal: JAMA (1891)

<h3>To the Editor:</h3> —On behalf of the officers of the Section on Materia Medica and Pharmacy of the American Medical Association, I invite the members to prepare papers to be read at the Detroit meeting of the Association. The first meeting of this section was held at Washington last May, and proved successful in every respect. The titles of papers for the section should be submitted as soon as determined. It will not be necessary to submit the article until a date nearer the coming meeting; for further information address the secretary of the Section,Dr. H. M. Whelpley, St. Louis.
CHOLERA IN THE PACIFIC.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
"CALCIUM AND PARATHYROID GLANDS IN RELATION TO HYPERESTHETIC RHINITIS"
Authors: Robert Sonnenschein
Journal: JAMA (1925)

<h3>To the Editor:</h3> —In Paragraph 1, the writers state that "it is neither reasonable nor scientific to establish a wide range of normality for the calcium content of the blood serum." Unfortunately, in the face of facts, it is impossible to establish a theoretical standard. Vines (The Parathyroid Glands in Relation to Disease, London, 1924), states very plainly that the amount of calcium present in the serums of normal individuals lies between 9 and 11 mg. per hundred cubic centimeters of serum, according to the methods of estimation used. This last phrase is of extreme importance, since our present-day methods of determining calcium content in the blood serum are not accurate. We are fortified in this statement by the opinions of leading laboratory workers and physiologists, among them Prof. A. J. Carlson of the University of Chicago. In their preliminary report (Novak and Hollender:The Journal, Dec. 15, 1923), workers
DISEASES AND HOSPITALS OF THE EAST COAST OF AFRICA.
Authors: NICHOLAS SENN
Journal: JAMA (1906)

Salisbury, Mashonaland, June 8, 1906. <h3>GERMANY'S BATTLE WITH TROPICAL DISEASES IN EAST AFRICA.</h3><h3>TUBERCULOSIS.</h3> No cases of tuberculosis have been seen among the natives living on the mountain plateaus in the interior. On the lowlands, and especially on the coast, where natives come most frequently in contact with foreigners, isolated cases of pulmonary tuberculosis are beginning to come to the notice of physicians, and I saw a few cases in the hospitals I visited. There is every reason to fear that this disease will become more and more prevalent, despite the efforts made to prevent its spread. The lung appears to be the organ pre-eminently predisposed to infection, as all the physicians whom I have met on the coast have never seen any cases of glandular, bone or joint tuberculosis, and among the thousands of natives that came under my observation I failed to find any of the remote results
Rectal bleeding in a 4-month-old boy
Authors: J. A. Dutro
Journal: JAMA (1986)

<h3>Clinical Information</h3> A 4-month-old boy was seen initially with a 24-hour history of painless hematochezia. His parents had noted two episodes of maroon-colored stool that did not appear to be associated with any abdominal distress. No history of hematemesis or diarrhea was obtained. His medical history was unremarkable, with normal growth and development. Physical examination revealed a well-nourished, well-hydrated infant in no apparent distress. Vital signs were normal. The abdomen was soft, with no palpable masses and active bowel sounds. Rectal examination revealed no masses, but bright-red blood was noted on the examining finger. Findings from the remainder of the examination were normal. Laboratory data demonstrated a hemoglobin level of 7.7 g/dL (77 g/L) and a hematocrit of 22.8% (0.22). The white blood cell count was 6600/mm<sup>3</sup>(6.6×10<sup>9</sup>/L). An upright roentgenogram of the abdomen was obtained and demonstrated no abnormalities. The abdominal technetium scan is shown in
Primary mesenteric vein thrombosis associated with antithrombin III deficiency
Authors: F. R. Arko
Journal: JAMA (1979)

PRIMARY mesenteric vein thrombosis associated with hereditary antithrombin III (AT III) deficiency has recently been reported as a new clinical entity.<sup>1</sup>Primary mesenteric vein thrombosis is a result of abnormal coagulation, whereas most cases of mesenteric vein occlusions are secondary to some other disease process. This case report of a patient who had segmental infarction, recurrent infarction, postresection morbidity, and clinical evidence of hypercoagulability depicts and reemphasizes the diagnostic and therapeutic difficulties encountered by the surgeon who must deal with this problem. <h3>Report of a Case</h3> A 47-year-old man was first seen with a six-day history of midepigastric pain and nausea. Pain was strikingly intensified by food ingestion. History disclosed deep-vein thrombosis in the left leg, for which the patient had received anticoagulant therapy three years previously. Family history disclosed that the patient's father died of peritonitis, which, according to the patient, was secondary to a "blood clot to
Severe thrombocytopenia suggesting immunological mechanisms in two cases of vivax malaria
Authors: Sayuri Yamaguchi, Tatsumi Kubota, Takahiro Yamagishi, Kiyoshi Okamoto, Tomoyuki Izumi, Masashi Takada, Shigeyuki Kanou, Mamoru Suzuki, Jun Tsuchiya, Takuji Naruse
Journal: American Journal of Hematology (1997)

Case 1: A 27-year-old woman, referred to our hospital because of relapsing fever after travel to Thailand, was given a diagnosis of vivax malaria. Clinical investigation revealed thrombocytopenia, elevated platelet-associated IgG (PAIgG), and negative antibody against Plasmodium vivax antigen. After antimalarial treatment, the levels of both the platelets and PAIgG returned to normal. Case 2: A 28-year-old Sri Lankan man was admitted to our hospital with a complaint of fever. The patient had thrombocytopenia, elevated PAIgG, and positive antibody against Plasmodium vivax antigen. He contracted malaria in Sri Lanka about 6 months prior to this admission. After treatment, the platelet count and PAIgG level returned to normal. In these two cases, high levels of PAIgG may have been involved in the development of the thrombocytopenia. In the first patient, in particular, the thrombocytopenia was thought to be induced by some immunological mechanism prior to the detection of antimaralial antibodies in serum. Am. J. Hematol. 56:183–186, 1997. © 1997 Wiley-Liss, Inc.