tbuckley/cabot-search huggingface dataset:
Pathologische Histologie. Ein Unterrichtskurs für Studierende und Aerzte.
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Motor accident mortality and compulsory inspection of vehicles
Authors: V. R. Fuchs
Journal: JAMA (1967)

The relation between motor accident mortality and compulsory vehicle inspection is examined by regressing age-standardized mortality ratios on inspection and other variables across states. The adjusted coefficient of multiple determination is typically about 0.85. Inspection is negatively related to mortality, but the net effect of inspection is less than one third as large as the gross difference between states that require inspection and those that do not and does not generally differ from zero at high levels of statistical significance. The effect of inspection appears to be greater in states with more than one annual inspection. It is greater in low income than in high income states, and greater in high education than in low education states. Dollar estimates of the benefits of inspection are found to exceed estimated costs; the difference, however, is not as large as is often alleged.
Machines and people: who and what are important?
Authors: H. G. Jacobson
Journal: JAMA (1984)

In the past decade, a startling revolution has occurred in diagnostic radiology with the introduction of highly sophisticated (and expensive) imaging equipment and the development of at least one new discipline. These additions include ultrasonography (US), computed tomography (CT), computed digital radiography, positron emission tomography, single-photon emission computed tomography, and, most recently, imaging with magnetic resonance (MR). The new discipline is interventional radiology in various anatomical sites (eg, angioplasty of coronary arteries, embolization by catheter of intracranial arteriovenous malformations). Information gained from these various developments has proved to be priceless. Definitive diagnoses are now possible in areas not even remotely envisioned in the past. Many examples abound, including, the diagnosis of fetal abnormalities in utero (by US) and myocardial infarcts (by MR). Thus, the newly acquired diagnostic skills of the radiologist have virtually changed the face of radiology and even the practice of medicine. Certain questions intrude, however: What is
Immune profile of gut mucosa t cells associated with e coli laden macrophages in crohn's disease
Authors: V. Avgousti, N. B. Rayment, T. Elliott, B. N. Hudspith, C. Karaiskos, J. Brostoff, J. D. Sanderson
Journal: Gut (2011)

<h3>Introduction</h3> There is increasing evidence that a defect in the handling of intracellular bacteria is involved in the pathogenesis of Crohn9s disease (CD). In CD, we have previously demonstrated a population of intestinal macrophages harbouring viable <i>E coli</i> and it is therefore possible that this failure of bacterial killing contributes to the observed inflammatory response. Previous studies showed that <i>E coli</i> laden (<i>E coli</i> positive) macrophages produce less TNFα compared to those not infected with bacteria (<i>E coli</i> negative). T cells are seen clustering around these infected macrophages suggesting T cell activation is altered between the innate and adaptive immune systems. <h3>Aims</h3> To use co-localisation immunofluorescent techniques to investigate the immunological profile of T cells associated with <i>E coli</i> positive and negative macrophages, and those from control mucosa. <h3>Methods</h3> Snap frozen mucosal biopsies were taken at routine colonoscopy from patients with CD and controls with normal colorectal mucosa and cryostat section made. <i>E coli</i> positive/negative macrophages were identified using CD-68 staining and a polyclonal anti <i>E coli</i> antibody and the T cells were identified using an anti CD3 antibody. In serial sections the T cells were labelled with anti IL10, IL17, TNFα, TGFβ, FoxP3 or IL23 receptor and the results analysed using confocal microscopy. <h3>Results</h3> The profile of T cells surrounding <i>E coli</i> positive macrophages compared to <i>E coli</i> negative macrophages demonstrated an elevated number of cells with a regulatory phenotype. More of these T cells expressed IL-10 (67% vs 11%; p=0.001) and FoxP3 (14% vs 2%; p= 0.001). In contrast, increased numbers of pro-inflammatory T cells were seen surrounding <i>E coli</i> negative macrophages as measured by cells staining positive for TNFα (22%), IL-17 (26%) and IL23 (30%), which were not seen in association with <i>E coli</i> positive macrophages. <h3>Conclusion</h3> There is an increased number and specific distribution of regulatory or inflammatory T cells surrounding lamina propria macrophages in CD according to intracellular persistence of <i>E coli</i>. The results suggest that despite <i>E coli</i> persistence, an appropriate immune containment occurs while it is the macrophages and T cells free of <i>E coli</i> which make the main contribution to active inflammation. Further studies are needed to determine the immune interplay between these populations and whether other microbial factors are present in <i>E coli</i> negative macrophages.
Paraquat Toxicity: Proposed Mechanism of Action Involving Lipid Peroxidation
Authors: James S. Bus, Steven D. Aust, James E. Gibson
Journal: Environmental Health Perspectives (1976)

The purpose of this study was to investigate the hypothesis that paraquat pulmonary toxicity results from cyclic reduction-oxidation of paraquat with sequential generation of superoxide radicals and singlet oxygen and initiation of lipid peroxidation. In vitro mouse lung microsomes catalyzed an NADPH-dependent, single-electron reduction of paraquat. Incubation of paraquat with NADPH, NADPH-cytochrome c reductase, and purified microsomal lipid increased malondialdehyde production is a concentration dependent manner. Addition of either superoxide dismutase or a single oxygen trapping agent 1,3-dipheylisobenzo furan inhibited paraquat stimulated lipid peroxidation. In vivo, pretreatment of mice with phenobarbital decreased paraquat toxicity, possibly by competing for electrons which might otherwise reduce paraquat. In contrast, paraquat toxicity in mice was increased by exposure to 100% oxygen and by deficiencies of the antioxidants selenium, vitamin E, or reduced glutahione (GSH). Paraquat, given IP to mice, at 30 mg/kg, decreased concentrations of the water-soluble antioxidant GSH in liver and lipid soluble antioxidants in lung. Oxygen-tolerant rats, which hae increased activities of pulmonary enzymes which combat lipid peroxidation, were also tolerant to lethal doses of paraquat as indicated by an increased paraquat LT50. Furthermore, rats chronically exposed to 100 ppm paraquat in the water had elevated pulmonary activities of glucose-6-phosphate dehydrogenase and GSH reductase.These results were consistent with the hypothesis that lipid peroxidation is involved in the toxicity of paraquat.
Predictors of positive test results in patients with cancer undergoing hepatitis B screening before chemotherapy.
Authors: Jessica Hwang, Anna S. F. Lok, Scott B. Cantor, Michael Fisch, Andrea G. Barbo, Heather Y. Lin, Maria E. Suarez-Almazor
Journal: Journal of Clinical Oncology (2016)

116 Background: Optimal hepatitis B virus (HBV) screening strategies for patients with cancer awaiting chemotherapy are unknown. We aimed to identify predictors of HBV infection in a large cohort of patients with cancer who were systematically screened for HBV before chemotherapy. Methods: In this prospective observational study, patients with cancer at MD Anderson Cancer Center awaiting first administration of chemotherapy in an outpatient chemotherapy unit were identified and approached for HBV screening. Enrolled patients completed a CDC risk survey and had blood tests to screen for HBV (HBsAg, anti-HBc) and hepatitis C virus (anti-HCV) infection. We developed a logistic regression model to identify clinical predictors of either chronic (HBsAg+/anti-HBc+) or resolved (HBsAg-/anti-HBc+) HBV infection. Model fit was assessed using the Hosmer-Lemeshow goodness-of-fit test. Results: From July 2013 to December 2014, 2124 patients (mean [SD] age, 58 [13] years) completed the risk survey and had HBV screening. Of these, 54% were women, 11% Hispanic, 77% non-Hispanic white, 8% black, and 4% Asian. Nearly 20% had a hematologic malignancy, 1% liver cancer, and 79% had a solid tumor other than liver cancer. Almost 12% of patients were born outside of the US. Seven patients (0.3%) had chronic and 128 (6%) had resolved HBV infection. Among the latter, 13 patients were also anti-HCV+. Predictors (odds ratio [OR]; 95% CI) of having either HBsAg+ or anti-HBc+ result included black race (4; 3-7), Asian race (4; 2-7), birthplace outside the US (5; 3-9), and having lived with someone with HBV (2; 1-4). Older age and lower education level were also predictive of positive HBV test results. Patients who reported ever injecting drugs (OR 10; 5-22) or being a man currently having sex with another man (OR 28; 6-135) had a high risk of HBsAg+ or anti-HBc+ result. The area under the curve for the model predicting positive HBV tests was 0.80. Conclusions: Known HBV risk factors are predictive of chronic or resolved HBV infection in patients with cancer. Future model validation using bootstrapping will allow varying levels of sensitivity in order to develop best HBV screening strategies.
The worldwide smoking epidemic. Tobacco trade, use, and control. Council on Scientific Affairs
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Council on Drugs. List No. 99. New names
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
FELLOWSHIPS IN MEDICAL JOURNALISM
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Early surgical treatment of valvular endocarditis
Authors: B. R. Wilcox
Journal: JAMA (1967)

Three patients with valvular destruction secondary to bacterial endocarditis were treated by early valvular replacement. Operative intervention prior to completion of the conventional prolonged course of antibiotic therapy was necessitated by hemodynamic collapse in two patients and by drug resistance in a third patient. Six weeks after valve replacement in the patient in case 1, he successfully underwent left pneumonectomy for carcinoma of the lung. Following surgery, the three patients are doing well, with no evidence of infection or congestive heart failure.
Neurology
Authors: Robert J. Joynt
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE MEDICAL SAMPLE BUSINESS.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
[776] Withdrawn
Authors: T Yoshida, S Yamagishi, H Koga, K Nakamura, T Matsui, T Imaizumi, T Ueno, M Depurtments, S Zelber-Sa~i',~, D Nitzan-Kaluski', Z Halpern'~~, R Orer~', ~ The
Journal: Journal of Hepatology (2007)
P1.09-21 Circulating Tumor DNA Improves Genotypification and Detection of Targetable Alterations in Selected Lung Cancer Patients
Authors: Z. Zatarain-Barrón, F. Barron, A. Cardona, G. Cruz-Rico, O. Arrieta, K. Flores-Veles, C. Espenschied, V. Raymond, R. Lanman, C. Vargas
Journal: Journal of Thoracic Oncology (2018)
Abstract 1603: Factors and Mechanisms Associated with Improved Cardiopulmonary Performance after Cardiac Resynchronization Therapy. An Exercise Echocardiography Study.
Authors: Juraj Madaric, Marc Vanderheyden, Christophe Van Lathem, Ann Feys, Sofie Verstreken, Marc Goethals, Bernard De Bruyne, Jozef Bartunek
Journal: Circulation (2007)

Background: Cardiac resynchronization therapy (CRT) leads to better cardiopulmonary performance in congestive heart failure (CHF) patients (pts). Mechanisms underlying the benefits are not fully elucidated. Aim: To investigate factors and mechanisms associated with improved cardiopulmonary performance after CRT. Methods: Twenty-three pts (EF 26±7%, QRS complex 170±26 msec) were studied by simultaneous quantitative semi-supine exercise echocardiography and cardiopulmonary exercise testing before and 3 months after CRT. Pts with an increase (Δ) in peak VO 2 ≥1.1 ml/kg/min were considered clinical responderes. Effective regurgitant orifice (ERO) of the mitral regurgitation (MR) was assessed using the PISA method. Results: In the entire population, CRT was associated with a decrease in LV dyssynchrony from 53±2 to 23±9 msec (p&lt;0.001), increase LV ejection fraction (EF) from 26±7 to 36±9% (p&lt;0.001) and ERO reduction from 0.24±0.11 to 0.13±0.06 cm 2 (p&lt;0.001) In addition, peak VO 2 increased from 11.6±2.3 to 12.9±3.6 ml/kg/min (p&lt;0.01) and Nt-pro BNP decreased from 2795±1644 to 2021±1353 pg/ml (p&lt;0.05). At follow-up (Table ), ERO at rest was similar but exercise-induced ERO and Nt-pro BNP were significantly lower in responders vs nonresponders. Change in peak VO 2 correlated inversely with the extent of exercise-induced MR at follow-up (r=−0.47, p&lt;0.05), with baseline Nt-pro BNP levels (r=−0.53, p&lt;0.05) and change in LVESV (r=−0.49, p&lt;0.05). Conclusions. Improved cardiopulmonary performance after CRT is related to changes in exercise-induced MR rather than resting MR. Thus, effects on the exercise-induced MR in parallel to reverse LV remodelling appear to contribute to improved cardiopulmonary performance and clinical benefits of the CRT.
Noah Webster and the medical profession
Authors: T. H. Brown
Journal: JAMA (1975)

BECAUSE Noah Webster's monumental philological achievement in compiling the great<i>American Dictionary</i>has long overshadowed his many other significant contributions to the cultural and educational development of the new nation, little attention has been given to his other accomplishments. However, as one commentator has observed, "he left some mark of his influence" on every field of activity he entered into, including medicine.<sup>1(p755)</sup> Born in West Hartford, Conn, in 1758, Webster graduated from Yale with the famous class of 1778. Yale's most distinguished class up to the Civil War included, besides Webster, Joel Barlow, poet and minister to France, and Josiah Meigs, publisher and President of the University of Georgia.<sup>2-4</sup>On his graduation at the age of 20, penniless, unemployed, and with no prospects for the future, Webster returned to his father's home in West Hartford, hoping to study law. But his father, having already mortgaged the family farm
A mechanically-engineered spray to increase brain penetration of chemotherapeutic nanoparticles in the treatment of high-grade gliomas
Authors: Phoebe McCrorie, Vincenco Taresco, Zeyuan Xu, Alison Ritchie, Phillip Clarke, Maria Marlow, Ruman Rahman
Journal: Neuro-Oncology (2019)

Abstract Design and implementation of innovative local drug delivery systems (DDS) may overcome current limitations in GBM treatment, such as the lack of therapeutic drug concentrations reaching residual GBM cells following surgery. Here we describe a novel DDS which utilises a bespoke mechanically engineered spray device, designed for safe surgical use, to deliver a mucoadhesive hydrogel containing chemotherapeutic nanoparticles (NPs) into the tumour resection margins. The overall aim is to spray a NP and polymer solution onto the resection cavity and potentially increase penetration of anti-cancer drugs within the 2 cm reoccurrence zone beyond the infiltrative margin. The mucoadhesive gel of choice, pectin, is currently used in other in vivo applications; however we have repurposed this for the brain. Pectin is biocompatible with GBM and human astrocyte cells in vitro and showed neither toxicity nor inflammation for up to 2 weeks upon orthotopic brain injection. Pectin is biodegradable in artificial CSF and is capable of being sprayed from the engineered device. A panel of polymeric, oil-based and polymer-coated NPs have been developed and optimised to maximise drug encapsulation of etoposide and olaparib as proof-of-concept for combination drug delivery. Etoposide/olaparib was chosen due to cytotoxicity from 5 GBM cell lines, including primary lines isolated from the invasive tumour margin (Mean IC50 of 1.1 µM and 8.3 µM respectively). The optimal NP/drug formulation (based on drug encapsulation, spray capability and bio-adhesiveness) will ultimately be assessed for tolerability and efficacy using orthotopic allograft and xenograft high-grade glioma models.
New Publication on Radiation and the LymphatiC System
Journal: JNCI Journal of the National Cancer Institute (1976)

Journal Article New Publication on Radiation and the LymphatiC System Get access JNCI: Journal of the National Cancer Institute, Volume 57, Issue 1, July 1976, Page 227, https://doi.org/10.1093/jnci/57.1.227-b Published: 01 July 1976