tbuckley/cabot-search huggingface dataset:
The Goal
Authors: None Name Withheld by Request
Journal: JAMA (1983)

I am the wife of a sixth-year surgical resident. My husband is in a highly selective surgical subspecialty. In a field replete with top-notch members, my husband competes and succeeds. The price of his success has been the loss of a meaningful life outside the hospital milieu. The life-and-death events that my husband handles on a daily basis with skill, dedication, and empathy perhaps have served as catalysts in his change from a loving, caring husband and father to an exhausted, passive "boarder" who only occasionally arrives home during daylight hours. The intensity of a surgeon's training has been traditionbound to "break the man but not his mind." Eight years ago, when we married, my husband was a medical student. I listened to him, as class president, deliver his medical school's graduation speech, and I did so with a commitment to help him become the physician he dreamed of becoming—a
Clinical Summaries
Journal: Circulation (2009)

This study tested whether low-amplitude shocks delivered via 2 field electrodes were capable of terminating atrial fibrillation in isolated perfused canine atria.Our expectation was that the fields induced by the 2 physical electrodes would create many "virtual" electrodes that could then be used to overdrive-pace the fibrillating tissue and thereby terminate fibrillation.The observation that this method, which we call far-field antifibrillation pacing, converted atrial fibrillation reliably (93% success rate) with the use of field strengths that were only 13% of the energy required to cardiovert with a single shock suggests that this method may have clinical utility.Cardioversion of atrial fibrillation with the use of lower energies could reduce the pain and tissue damage associated with a large single shock and prolong the battery life of implantable devices.Further experimental studies are needed, however, to optimize the shock protocol and to determine whether far-field antifibrillation pacing is effective and safe in vivo.See p 467.
Ethical conundrums: they just keep on coming
Journal: BMJ (2002)

NHS nursing shortages: retention is the biggest problem About a third of newly graduating nurses in the United Kingdom do not register to practise, and no one knows why.In their two part discussion of the nursing crisis in the NHS (pp 538, 541) Finlayson and colleagues document the changing structure of the nursing profession in the UK, with fewer nurses trained in the UK and a rising average age.Staffing shortages-which raise costs and reduce morale-are most acute in hospitals in London and other inner cities.The government is trying to tackle the major underlying causes by increasing pay, recruiting extra nurses to help relieve heavy workloads, extending the clinical roles of nurses, and trying to counter racism and violence and foster family friendly policies.But, argue the authors, these initiatives may not be enough.Workforce issues are still nowhere near the top of managers' agendas.
Calcium and parathyroid disorders in children. Chronic renal failure and treatment with calcitriol
Authors: J. C. Chan
Journal: JAMA (1979)

Progression of renal failure, represented by rising serum creatinine concentrations, was correlated with progressive elevation of serum parathyroid hormone (PTH) concentrations in 23 children. A significant linear relationship was established. Despite normal serum calcium concentrations in 11 children receiving maintenance hemodialysis, circulating PTH concentrations were elevated after six months. Progressive deterioration with time occurred in all variables tested, at six-month intervals. These complications were reversible with kidney transplantation or treatment with 0.25 to 2 μg/day of calcitriol for four to 20 weeks. (<i>JAMA</i>241:1242-1244, 1979)
Bcl-2 is overexpressed and alters the threshold for apoptosis in a cholangiocarcinoma cell line
Authors: D Harnois
Journal: Hepatology (1997)

Cholangiocarcinoma is a malignant neoplasm originating from cholangiocytes. The mechanisms responsible for oncogenesis of cholangiocytes are unknown. Resistance to apoptosis, especially by altered expression of B-cell lymphoma/leukemia 2 (Bcl-2) family members, has been implicated as a mechanism contributing to malignant transformation. Thus, our aim was to test the hypothesis that altered expression of Bcl-2 family members by cholangiocarcinoma cells renders them resistant to apoptosis. We compared the apoptotic threshold and expression of the Bcl-2 protein family members, Bcl-2, Bcl-XL, and Bax, in two human cell lines: 1) nonmalignant human cholangiocytes immortalized by transfection with the simian virus 40 (SV 40) large T antigen; and 2) a malignant human cholangiocarcinoma cell line. Apoptosis was induced pharmacologically using beauvericin. Bcl-2, Bcl-x long, and Bax protein expression were evaluated by immunoblot analysis, and Bcl-2 expression was modulated using antisense technology. The cholangiocyte and malignant/nonmaligant phenotype of both cell lines was verified using both in vitro and in vivo approaches. Beauvericin induced apoptosis of nonmalignant cholangiocytes in a concentration- (0 to 25 µmol/L) and time- (0 to 6 hours) dependent manner. In contrast, malignant cholangiocytes were resistant to apoptosis. Although expression of Bcl-x long and Bax protein were similiar in the two cell lines, Bcl-2 protein expression was 15-fold greater in malignant than in nonmalignant cholangiocytes. An 18 mer bcl-2 antisense oligonucleotide reduced expression of Bcl-2 protein by 50% and increased the rate of beauvericin-induced apoptosis more than threefold in the malignant cells. Our results support the hypothesis that resistance to apoptosis by overexpression of Bcl-2 may be a feature of cholangiocarcinoma.
NCCN NewsNCCN Launches NCCN Congress Webinar Series: Biomarkers 101NCCN Radiation Therapy Compendium is Now Complete, Providing Radiation Treatment Recommendations for All 41 Disease SitesNew Patient Guidelines From NCCN Offer Much-Needed Clarity Around a Group of Rare Blood CancersNCCN Academy Brings Together Experts to Deliberate Challenges and Opportunities for Patient Access, Collaboration, and Guidelines Development
Authors: Ross Camidge, John Pfeifer
Journal: Journal of the National Comprehensive Cancer Network (2017)

NCCN will host its latest live webinar series-Biomarkers 101.Through the NCCN Congress Webinar Series: Biomarkers 101, esteemed faculty from NCCN Member Institutions provide updates on the latest advances in the use of biomarkers in state-of-the-art care for patients with cancer.The science and practice of oncology are rapidly evolving based on more complete knowledge of cancer genomes and the specific genetic events that drive cancer.This knowledge, coupled with advances in medicinal chemistry, has ushered in an era of precision oncology.Use of molecular testing followed by therapies tailored to the particular molecular landscape of a patient's disease can allow appropriate therapies to be given to patients who are most likely to benefit, while avoiding unnecessary treatment of patients who are unlikely to benefit.Although the availability of new cancer biomarkers is encouraging for diagnosis, prognosis, and treatment decision-making, determining the clinical usefulness and selection of the appropriate testing methodologies can represent a daunting challenge for practitioners.With the field of biomarkers rapidly advancing, clinical research directly affects how oncologists manage patients.Keeping up with advances in biomarker testing allows clinicians to offer state-of-the-art care to their patients with cancer and to better identify patients that are appropriate for biomarker-directed clinical trials.The Biomarkers 101 series includes the following webinars:• What Are Biomarker Tests and How Are They Approved?Friday, November 3
Melioidosis
Authors: E. B. Cooper
Journal: JAMA (1967)

Because of the return of a large number of persons, both military and civilian, from Southeast Asia, knowledge of melioidosis, endemic to that area, is of great importance. Through February 1967, 35 cases have been diagnosed in USA troops from that area, with eight fatalities. (Nine fatalities were reported by the Office of the Surgeon General, but one fatality included on the basis of clinical diagnosis proved, on autopsy, not to have been due to melioidosis.) Melioidosis is a disease of man and animals caused by a gram-negative motile bacillus,<i>Pseudomonas pseudomallei</i>. It is most commonly recognized as an acute pneumonia, but the clinical picture is variable, with a spectrum which includes asymptomatic infections manifested only by a positive serological reaction, asymptomatic pulmonary infiltration, acute toxic pneumonitis, and overwhelming fatal septicemia. Localized extrapulmonary forms may occur in any organ of the body. The disease may present several years after an
A Culdoscopy Support
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Serum enzyme alterations in neuromuscular disorders
Authors: T. L. Munsat
Journal: JAMA (1973)

Serum enzyme studies were made on a large, well-defined group of patients with neuromuscular diseases. Control values for creatine phosphokinase, aldolase, and lactic dehydrogenase were significantly higher in males. (P&lt;.05,.005, and.01, respectively). A rapid drop in creatine phosphokinase was observed after age 10 in patients with Duchenne dystrophy, and after age 20 in carriers with elevated enzyme levels. A significant negative age-enzyme correlation for creatine phosphokinase levels in carriers was observed (r = —.48, P&lt;.01). This emphasizes the importance of early carrier detection studies in the suspect female patient. Elevations in the Becker and Duchenne forms of X-linked dystrophy were found to be similar in frequency and degree, even though the rapidity of cellular breakdown is quite different. Of all the disorders studied, only spinal muscular atrophy demonstrated a positive correlation for creatine phosphokinase disease duration.
Analgesic Nephritis
Authors: Francis X. Fellers
Journal: JAMA (1963)

<h3>To the Editor:</h3> —We have read with interest the articles on analgesic nephritis by Reynolds and Edmondson and by Harrow and his associates in the May 11 issue ofThe Journal(<b>184</b>:435, 445). With the young albino rat as the experimental animal, we have been able to reproduce the characteristic lesion of renal papillary necrosis and renal tubular acidosis following the administration of salicylate or salicylate and acetazolamide sodium. These lesions occur with serum levels of salicylate (20-70 mg/100 ml) comparable to those obtainable in humans with the described oral dosage of 100 mg/kg by weight per day, which, in the face of the described severe renal impairment, were most likely cumulative levels. Although bacterial cultures of the urine or kidney tissues were not made in these animals, microscopic studies of these tissues involved failed to show an inflammatory response or the presence of bacteria in the kidney lesions
Cracking urinary bladder stones.
Journal: BMJ (1977)

Low birth weight should be avoided because it threatens the life of the child and prejudices growth and nonverbal intelligence among apparently normal survivors. Clearly the length of gestation has an important effect on the birth weight. Sex also influences birth weight as does birth order. It is suggested that the increased birth weight of 2nd births is due to the increased serum volume of the mother. In the 1st pregnancy serum volume is at its peak at 34 weeks. In the succeeding pregnancy this peak is reached at 30 weeks. Other determinants of fetal birth weight are environmental temperature, altitude, nutritional status, exposure to particular disease, and smoking. It is important to identify possible conditions in the patient which might lead to low birth weight and to remedy them.
A lean, mean cyclotron revs up neutron therapy
Authors: T. Randall
Journal: JAMA (1992)

THE STATE-OF-THE-ART in both physics and medicine joined forces again recently when the first superconducting cyclotron dedicated to cancer therapy began to be used for treating patients at Harper Hospital in Detroit, Mich. Radiation oncologists there say they hope to achieve the potential benefits of neutron therapy by uniting this powerful technology with several other independent advances, such as threedimensional treatment planning and tailoring the neutron beam to the shape of the tumor. With the new cyclotron, oncologists say they now can conduct a more evenhanded comparison between neutron and
Transjugular intrahepatic portosystemic shunt in cirrhotic elderly patients with refractory ascites - to do or not to do?
Authors: Lena Thöle, Marie Schultalbers, Tammo Lambert Tergast, Svetlana Gerbel, Jan Hinrichs, Nicolas Simon, Markus Cornberg, Michael P. Manns, Bernhard Meyer, Benjamin Maasoumy
Journal: Journal of Hepatology (2020)
Consultant Contract
Authors: G. d. B. Mitford-Barberton, P. S. Andrews, H. J. Voss, L. R. MacLean, P. E. Wallace, E. G. Hadaway, D. E. Sibson, J. M. Ritchie, B. K. Samtani, I. S. Hodgson-Jones, A. B. Jones, T. H. Cullen, P. Willis, R. M. Ingram, G. Gerrard, T. Partington, T. C. Beer, J. R. Pettman, G. Baines
Journal: BMJ (1974)
FALL OF BLOOD PRESSURE AFTER INJECTIONS OF NEO-ARSPHENAMIN
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
LAW &amp; MEDICINE
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Announcement
Journal: Psychotherapy and Psychosomatics (1975)

s Welfare (IMAN).The Inter-American Conference on Mental Health of Children and Youth will be formed with the professionals appointed as active participants, by the National Committees of the American countries, by the experts appointed by the Organizing Committee, by the officials of the Inter-American Council of Psychiatric Associations, by the technical adminis trative staff of IMAN, and by an undetermined number of observers and special guests.The number of active participants will be limited to 400.Each participant will be responsible for his travelling, hotel and food expenses during the 3 days of the Conference.Each active participant shall pay a $ 500 fee (five hundred pesos Mexican currency).
Congenital defects of the abdominal wall. A review of the experience in New Mexico
Authors: M. D. Klein
Journal: JAMA (1981)

Omphalocele, umbilical cord hernia, and gastroschisis are surgically correctable defects of the abdominal wall. Each of these defects has a distinct embryologic basis that results in a characteristic clinical picture. Twenty-five infants with congenital defects of the abdominal wall were treated at the University of New Mexico Hospital in the past four years. Six infants had omphalocele, one had umbilical cord hernia, and 18 had gastroschisis. Survival among infants who underwent a corrective operation was as follows: omphalocele, 50%; umbilical cord hernia, 100%; and gastroschisis, 82%. Long-term survival for the entire group was 72% (18/25). Gastroschisis, which had a lower incidence of major associated anomalies, had a better prognosis than omphalocele. The mortality of congenital abdominal wall defects was related to presence of severe associated anomalies and to poor clinical condition on admission. Prompt and informed initial care may increase the chance of survival. (<i>JAMA</i>1981;245:1643-1646)
A NEWSPAPER FREE FROM NOSTRUM ADS.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Neonatal herpes simplex virus infection occurring in second twin of an asymptomatic mother. Failure of a modern protocol
Authors: W. A. Growdon
Journal: JAMA (1987)

A case of neonatal herpes that occurred after vaginal delivery in the absence of genital lesions is presented. The mother had a history of drug addiction and genital herpes. Asymptomatic shedding of herpes simplex virus type 2 from the cervix was noted in the second trimester of pregnancy. Despite being followed with a protocol of close surveillance and serial culturing of the genital tract, the patient gave birth to twins, one of whom developed herpes simplex virus type 2 in the postpartum period. This report presents discussion of this case and herpes surveillance protocols. (<i>JAMA</i>1987;257:508-511)
Two-year biochemical, virological, and histological follow-up in patients with chronic hepatitis c responding in a sustained fashion to interferon alfa-2b treatment*1
Authors: O REICHARD
Journal: Hepatology (1995)

Fourteen patients with chronic hepatitis C who had a sustained response to a 60-week interferon alfa-2b treatment course were followed, biochemically and virologically, 2 years after treatment cessation. Biopsies were repeated in 12 of 14 for histological and virological evaluation at 2-year follow-up. All 14 patients had normal serum alanine transaminase (s-ALT) levels and were negative for hepatitis C virus (HCV) RNA in serum during treatment and at short-term follow-up 6 months post-treatment. At 2-year follow-up, 13 patients still had normal ALT levels (<0.6 μkat/L for women; <0.8 μkat/L for men), 1 a near normal level (0.76 μkat/L); all were HCV RNA negative in serum, and 11 of 12 also in the liver. Liver histology improved during treatment and remained stable during the 2-year follow-up. The authors conclude that most sustained responders, who have normal ALT levels and are nonviremic at short-term follow-up 6 months after interferon treatment, will continue to have a durable long-term response without relapse of the viremia.