tbuckley/cabot-search huggingface dataset:
A man with upper respiratory tract infections, general weakness and fever
Authors: MV Berge, WJ Snoek, EW Nijboer, AJ Julius, R Aalbers
Journal: European Respiratory Journal (1999)

Mucociliary clearance (MCC), the process in which airway mucus together with substances trapped within are moved out of the lungs, is an important defence mechanism of the human body.Drugs may alter this process, such that it is necessary to know the effect of the drugs on MCC.Indeed, agents stimulating MCC may be used therapeutically in respiratory medicine, especially in patients suspected of having an impairment of their mucociliary transport system.In contrast, caution should be taken with drugs depressing MCC as an undesired side-effect, independently of their therapeutic indication.Since cough clearance (CC) serves as a back-up system when MCC fails, the influence of drugs must be examined not only on MCC but also on CC.Ultimately, the clinical repercussions of alterations in mucus transport induced by drug administration must be studied.Tertiary ammonium compounds (anticholinergics), aspirin, anaesthetic agents and benzodiazepines have been shown to be capable of depressing the mucociliary transport system.Cholinergics, methylxanthines, sodium cromoglycate, hypertonic saline, saline as well as water aerosol have been shown to increase MCC.Adrenergic antagonists, guaifenesin, S-carboxymethylcysteine, sodium 2-mercapto-ethane sulphonate and frusemide have been reported not to alter the mucociliary transport significantly.Amiloride, uridine 5'-triphosphate (UTP), quaternary ammonium compounds (anticholinergics), adrenergic agonists, corticosteroids, recombinant human deoxyribonuclease (rhDNase), N-acetylcysteine, bromhexine and ambroxol have been reported either not to change or to augment MCC.Indirect data suggest that surfactant as well as antibiotics may improve the mucociliary transport system.As for the influence of drugs on CC, amiloride and rhDNase have been demonstrated to increase the effectiveness of cough.A trend towards an improved CC was noted after treatment with adrenergic agonists.The anticholinergic agent ipratropium bromide, which is a quaternary ammonium compound, has been suggested to decrease CC significantly.Bromhexine, ambroxol and neutral saline seemed not to alter CC, either positively or negatively.Finally, treatment with either amiloride, recombinant human deoxyribonuclease, bromhexine, ambroxol, N-acetylcysteine, S-carboxymethylcysteine or hypertonic saline has been suggested as a possible cause of clinical improvement in patients, such as the experience of dyspnoea, the case of expectoration or the frequency of infective exacerbations.Other agents did not show a clinical benefit.
National health care reform. The aura of inevitability intensifies
Authors: G. D. Lundberg
Journal: JAMA (1992)

Major political change in a democratic republic such as ours comes about when a cluster of forces temporally coalesces to form a critical political mass of sufficient strength to power that change. Sometimes, tangential, seemingly unrelated events create that coalescence although the need for such change, people wanting it, and the resources necessary to produce it were long present. So it is with national health care reform in this country. See also pp 2503 and 2509. In my opinion, five salient events have brought health care reform to the forefront of the US national agenda: 1. The nasty recession that began in 1990 and has lingered into 1992, causing large numbers of politically active voters without adequate health insurance to join the politically impotent poor in insisting on reform. 2. The expanding tragedy of the AIDS epidemic, which created a large new group of highly educated and financially secure individuals
PAROXYSMAL TACHYCARDIA ASSOCIATED WITH PREGNANCY
Authors: D. F. Anderson
Journal: BMJ (1932)

seen to have a golden brown material deposited around them.Many, especially the bodies that have slender spicules as central cores, present the double and single bulbous ends and the-annular arrangement of the deposit so frequently seen in the bodies in asbestosis.In asbestosis these bodies are present in myriads, and are of all sizes and shapes, from minute forms resembling streptococci to bodies 130 , or more in length, as in Fig. 1 on Plate.Their size depends upon the length of the fibre and the size of the particles of asbestos dust which act as nuclei.In chrysotile dust there are black angular particles of biotite and magnetite, and in asbestosis some of these particles have the same appearance as those found in this case, and showvn in Figs. 7, 8, 9, and 10.The particles in powdered iron pyrites closely resemble the large spicules.The curious bodies are not nearly so numerous or so varied in form as in asbestosis.Tylecote and Dunn4 have recently published the finding of
Proceedings and Addresses at a Sanitary Convention held at Hanover, Mich., June 3 and 4, 1897.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE PUBLIC SERVICES
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Randomized phase III trial of imatinib (IM) rechallenge versus placebo (PL) in patients (pts) with metastatic and/or unresectable gastrointestinal stromal tumor (GIST) after failure of at least both IM and sunitinib (SU): RIGHT study.
Authors: Yoon-Koo Kang, Min-Hee Ryu, Baek-Yeol Ryoo, Hyun Jin Kim, Jong Jin Lee, Changhoon Yoo, Byung-Ho Nam, Nikhil Ramaiya, Jyothi Priya Jagannathan, George D. Demetri
Journal: Journal of Clinical Oncology (2013)

LBA10502 Background: To palliate and prolong disease control after failure of all available treatment in advanced GIST, resumption of IM dosing has been commonly practiced based on evidence of rapid GIST progression after discontinuation of all TKIs. We evaluated the efficacy of IM rechallenge in pts with advanced GIST following failure of all TKIs. Methods: Eligible pts had metastatic and/or unresectable GIST with prior benefit from first-line IM (defined as disease control for &gt; 6 months), progressive disease (PD) on first-line IM, PD on or intolerance to SU, and ECOG performance status 0-3. Pts were randomized 1:1 to receive best supportive care with either IM 400 mg po once daily or PL. At the time of PD, pts were unblinded and allowed to cross-over to open-label IM. The primary endpoint was progression-free survival (PFS) determined by blinded external radiology review according to RECIST v1.0. Secondary endpoints included overall survival (OS), time to progression, disease control rate (DCR) at 12 weeks, and safety. Results: Between July 2010 and January 2013, 81 pts were randomized (IM: 41, PL: 40) at a single Korean center. All baseline characteristics were balanced between the arms and 40% of pts received ≥ 3 prior TKIs. The planned final analysis in March 2013 demonstrated that the primary endpoint was met, with significantly greater PFS for pts randomized to IM vs. PL : 1.8 vs. 0.9 months, respectively (p=0.002), hazard ratio (HR) 0.45 (95% CI, 0.27-0.76). DCR at 12 weeks was 32% for IM vs. 5% for PL (p=0.003). With 92.5 % of PL pts rapidly crossing over to IM, median OS was 8.2 months for IM vs. 7.5 months for PL (HR of 0.99, p=0.982). The most common treatment-emergent AEs (&gt; grade 3) during double-blind period in the IM arm included anemia (29%), fatigue (10%), and hyperbilirubinemia (7%). Conclusions: Rechallenge of IM significantly improves PFS and DCR in pts with advanced GIST after failure of at least IM and SU, likely by continuous kinase inhibition of the bulk of disease clones which retain IM sensitivity. However, TKI-resistant clones continue to progress leading to relatively brief duration of benefit. Clinical trial information: NCT01151852.
Tracheogenic Carcinoma
Authors: Eugene J. Ranke
Journal: JAMA (1962)

The occurrence of tracheogenic carcinoma has not paralleled the increasing occurrence of primary cancer of the bronchi and larynx. Only one of 1,000 patients with cancer can be expected to have primary carcinoma of the trachea. Early diagnosis may be obscured and delayed because of the paucity of identifying symptoms and findings. Tracheogenic carcinoma should be suspected in a patient with a negative chest x-ray film who has a hacking, irritating cough with paroxysmal, alarming, wheezing episodes and occasionally blood-streaked sputum. Surgical resection procedures and cobalt-60 therapy have increased the effectiveness of treatment.
Acute Hemorrhagic Conjunctivitis
Authors: Peter A. Patriarca
Journal: JAMA (1983)

An outbreak of acute hemorrhagic conjunctivitis (AHC) due to enterovirus type 70 occurred in Dade County, Florida, from September to December 1981. Younger age groups, members of larger households, and the poor were at significantly greater risk of acquiring AHC than others in the community. Schoolchildren were most likely to introduce AHC into the household. After exclusion of all affected children from school, there was a dramatic reduction in reported cases, with attack rates declining more rapidly for school-aged children than for other age groups. Although AHC spread readily among family members, a retrospective study of 124 affected households showed an association between lower attack rates and simple hygienic measures. Should outbreaks of AHC recur, measures to reduce transmission should include exclusion of affected schoolchildren and educating the public about hygienic precautions. (<i>JAMA</i>1983;249:1283-1289)
Book Review Clinical Tuberculosis Edited by P.D.O. Davies. 426 pp., illustrated. New York, Chapman &amp; Hall, 1994. $99.95. 0-412-48630-X Tuberculosis: Current concepts and treatment Edited by Lloyd N. Friedman. 366 pp., illustrated. Boca Raton, Fla., CRC Press, 1994. $179.95. 0-8493-4825-0 Tuberculosis: Pathogenesis, protection, and control Edited by Barry R. Bloom. 637 pp., illustrated. Washington, D.C., ASM Press, 1994. $72. 1-55581-072-1
Authors: Keith P.W.J. McAdam
Journal: New England Journal of Medicine (1995)
Conference on Alternatives to Mastectomy 1982: Conservative Surgery and Radiation as Primary Treatment for Early Breast Cancer
Journal: JNCI Journal of the National Cancer Institute (1981)

Journal Article Conference on Alternatives to Mastectomy 1982: Conservative Surgery and Radiation as Primary Treatment for Early Breast Cancer Get access JNCI: Journal of the National Cancer Institute, Volume 67, Issue 6, December 1981, Page 1369, https://doi.org/10.1093/jnci/67.6.1369-c Published: 01 December 1981
Amer J of Roentgenology, Springfield, Ill
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Unusual complication from a cardiac pacemaker
Authors: W. E. Matern
Journal: JAMA (1977)

WE PRESENT an unusual complication that resulted from pacemaker placement in the abdominal wall. <h3>Report of a Case</h3> An 86-year-old man was admitted to the hospital in January 1977 because of severe cramping abdominal pain, nausea, and vomiting, starting six hours earlier. In March 1972, a bipolar demand pacemaker was placed in the left lower abdominal quadrant between the peritoneum and the deep fascia, because of complete heart block. The abdominal site was chosen because a pacemaker previously placed in the right anterior chest wall became infected. The abdominal pacemaker functioned well until September 1974, when the rate slowed spontaneously. A chest x-ray film showed a broken lead. Surgery was then performed and the lead found to be conducting poorly. This lead was capped, creating a unipolar system. On this present admission, physical examination disclosed blood pressure, 120/90 mm Hg; pulse rate, 96 beats per minute; respirations, 32/min; and temperature,
Transmission of herpes simplex virus type 1 infection in rugby players
Authors: W. B. White
Journal: JAMA (1984)

Skin infections, both bacterial and viral, are endemic in contact sports such as wrestling and rugby football. In this report, we describe four cases of extensive cutaneous herpes simplex virus in players on a rugby team. All players had a prodrome of fever, malaise, and anorexia with a weight loss of 3.6 to 9.0 kg. Two players experienced ocular lesions associated with cutaneous vesicular lesions of the face. A third player, who had herpetic lesions on his lower extremity, experienced paresthesias, weakness, and intermittent urinary retention and constipation. All infected players on the team were forwards or members of the "scrum," which suggests a field-acquired infection analogous to the herpetic infections seen in wrestlers (herpes gladiatorum). Considering the serious sequelae of recurrent herpes simplex keratitis, the traumatic skin lesions in rugby football players should be cultured for herpes virus, and infected individuals should be restricted from playing until crusted lesions have disappeared. (<i>JAMA</i>1984;252:533-535)
Contents
Authors: Jean-Claude Mwanza, Jonathan Oakley, Donald Budenz, Douglas Anderson, Harsha Rao, Addepalli Kumar, B Opt, Jonnadula Babu, Sirisha Senthil, Chandra Garudadri, Shenton Chew, Sushil Vasudevan, Hussain Patel, Lulu Gurria, Nathan Kerr, Greg Gamble, Jonathan Crowston, Helen Danesh-Meyer, Nicola Rosa, Michele Lanza, Maria Borrelli, Maddalena De Bernardo, Alberto Palladino, Maria Grazia, Di Gregorio, Fabrizia Pascotto, Luisa Politano, Jose Santiago Lo ´pez-Garcı ´a, Luis Rivas Jara, Isabel Garcı ´a-Lozano, Eduardo Conesa, Isabel Elosua De Juan, Juan Murube, Del Castillo, Ludwig Heindl, Stephan Riss, Bjoern Bachmann, Kathrin Laaser, Friedrich Kruse, Claus Cursiefen, Yanny Cheng, Nienke Visser, Jan Schouten, Robert-Jan Wijdh, Elisabeth Pels, Hugo Van Cleynenbreugel, Catharina Eggink, Michel Zaal, Wilhelmina Rijneveld, Rudy Nuijts
Journal: Ophthalmology (2011)
PHARMACOLOGY OF THE ORGANIC NITRATES.
Journal: JAMA (1900)

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Abortion
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Lipid Research Clinics Coronary Primary Prevention Trial results. II. The relationship of reduction in incidence of coronary heart disease to cholesterol lowering
Journal: JAMA (1984)

In the Lipid Research Clinics Coronary Primary Prevention Trial (LRC-CPPT), a 19% lower incidence of coronary heart disease (CHD) in cholestyramine-treated men was accompanied by mean falls of 8% and 12% in plasma total (TOTAL-C) and low-density lipoprotein (LDL-C) cholesterol levels relative to levels in placebo-treated men. When the cholestyramine treatment group was analyzed separately, a 19% reduction in CHD risk was also associated with each decrement of 8% in TOTAL-C or 11% in LDL-C levels (P less than .001). Moreover, CHD incidence in men sustaining a fall of 25% in TOTAL-C or 35% in LDL-C levels, typical responses to the prescribed dosage (24 g/day) of cholestyramine resin, was half that of men who remained at pretreatment levels. Adherence to medication was associated with reduced incidence of CHD only when accompanied by falls in TOTAL-C and LDL-C levels. Small increases in high-density lipoprotein cholesterol levels, which accompanied cholestyramine treatment, independently accounted for a 2% reduction in CHD risk. Thus, the reduction of CHD incidence in the cholestyramine group seems to have been mediated chiefly by reduction of TOTAL-C and LDL-C levels.
Fatal tricuspid valve obstruction due to a large infected thrombus attached to a Hickman catheter
Authors: A. Chakravarthy
Journal: JAMA (1987)

LONG-TERM home parenteral nutrition (HPN) has been associated with septic, mechanical, and metabolic complications.<sup>1,2</sup>We recently observed a catheter-related complication that has not, to our knowledge, been reported in an adult. A large infected thrombus was attached to the tip of a Hickman catheter and obstructed the tricuspid orifice; it was probably the source of the patient's fever of undetermined origin, metastatic soft-tissue infections, and death. <h3>Report of a Case</h3> A 56-year-old woman with a history of arthritic symptoms was diagnosed to have progressive systemic sclerosis on the basis of Raynaud's phenomenon, sclerodactyly, finger ulcers, dysphagia, telangiectasis, antinuclear antibody (positive at a 1:4096 titer, nucleolar pattern), and rheumatoid factor (reactive at a 1:640 titer). During the next two years, her symptoms worsened. She was hospitalized three times in two months for recurrent bouts of intestinal pseudo-obstruction. A Hickman catheter was placed for HPN after efforts at enteral nutrition failed.
Massachusetts Medical Society
Authors: John Figgis Jewett
Journal: New England Journal of Medicine (1956)

COMMITTEE ON MATERNAL WELFAREHeart Disease and Congestive Heart FailureA twenty-four-year-old gravida III, para I, with serious rheumatic heart disease known to have been present since childhood, died approximately three weeks before term.With a history of chorea at fourteen years of age, asymptomatic mitral stenosis and aortic stenosis had been diagnosed and were clinically insignificant until the fifth month of the first pregnancy, when pulmonary edema followed an upper respiratory infection. Digitalized and dehydrated by salt restriction the patient suffered a spontaneous miscarriage. At that time she had atrial fibrillation.Four months later, persistent left-sided heart failure with . . .