tbuckley/cabot-search huggingface dataset:
Measurable Residual Disease (MRD) in Elderly Acute Myeloid Leukemia (AML): Results from the Pethema-Flugaza Phase III Clinical Trial
Authors: Catia Patricia Simoes, Bruno Paiva, David Martínez-Cuadron, Juan-Miguel Bergua, Susana Vives, Jesús Lorenzo Algarra, Mar Tormo, Pilar Martinez, Josefina Serrano, Pilar Herrera, Fernando Ramos, Olga Salamero, Esperanza Lavilla, Cristina Gil, Jose Luiz Lopez Lorenzo, Maria-Belen Vidriales, Jorge Labrador, José F. Falantes, Maria Jose Sayas, Rosa Ayala, Joaquin Martinez-Lopez, Sara Villar, María José Calasanz, Felipe Prosper, Jesús F. San-Miguel, Miguel A. Sanz, Pau Montesinos
Journal: Blood (2020)
Quotations
Authors: George E. Ehrlich
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hemodialysis
Authors: Lazaro Gotloib
Journal: JAMA (1978)

PATIENTS with glomerulonephritis, chronic uremia, or nephrotic syndrome and uremic patients receiving maintenance hemodialysis<sup>1</sup>have elevated plasma vitamin A levels.<sup>1-3</sup>Plasma carotene levels are elevated in nephrotic patients.<sup>3</sup>Data concerning the influence of hemodialysis on vitamin A and carotene levels in plasma are lacking however. This study was designed to supply these data. <h3>Materials and Methods</h3> Hemodialysis was carried out on ten patients with chronic uremia, by means of a coil dialysis unit with 1.45 sq mm of dialyzing surface for eight hours twice weekly, by the standard technique. Blood samples were taken before and after eight hours of hemodialysis. Plasma was separated, and lipids were extracted with ethanol-petroleum ether (1:1 v/v).<sup>4</sup>Carotenoids were determined at 450 Armstrong units and vitamin A by the Carr-Price reaction<sup>5</sup>with a correction for carotenoids as described by Moore.<sup>4</sup>In some samples, β-carotene was separated from other carotenoids
St. Jude Children's Research Hospital Journey Fellowship in Biomedical Research
Journal: JNCI Journal of the National Cancer Institute (1985)

St. Jude Children's Research Hospital Journey Fellowship in Biomedical Research Get access JNCI: Journal of the National Cancer Institute, Volume 75, Issue 1, July 1985, Page 183, https://doi.org/10.1093/jnci/75.1.183-b Published: 01 July 1985
SUBOCCIPITAL MENINGOCELE
Authors: Anatole Kolodny
Journal: JAMA (1933)

<h3>To the Editor:</h3> —InThe Journal, January 28, is published a report by Dr. O. H. Fulcher of the removal of a suboccipital meningocele. Concluding his report, Dr. Fulcher says: "Suboccipital meningocele is a condition that is rare. Usually the treatment has been quite unsatisfactory. This is the first case, to my knowledge, that a suboccipital meningocele has been successfully treated by a one-stage operation." In September, 1928, while in the Iowa University hospital, I operated on a railroad employee from Davenport, Iowa, who was 40 years old and who had a suboccipital meningocele the size of the patient's fist. This was a one stage operation and a cure was accomplished. In 1929, in the same university hospital, I operated on a child, 2 months old, from Sioux City, with an enormous suboccipital meningocele, which was the size of the child's head. The same child also bad a lumbar spina
The role of diuretics in the treatment of heart failure
Authors: G. A. Porter
Journal: JAMA (1980)

TRADITIONALLY, nephrologists have focused on a defect in the salt-excreting capacity of the kidney as pivotal to edema formation in heart failure.<sup>1</sup>Furthermore, based on the concept of "effective central blood volume," they have argued that the renal response is appropriate to the afferent stimuli impacting the kidney, ie, "relative hypoperfusion of the kidneys." Thus, it seems logical that the first order for therapeutic management of congestive heart failure (CHF) would involve elimination of the excess salt and water contained principally in the extracellular volume (ECV). To accomplish this, pharmacologically active diuretic compounds have been employed with both substantial success and recognized imperfections. One might inquire as to the logic of causing a diureticinduced volume depletion that will cause a fall in cardiac output through a reduction in left ventricular end-diastolic pressure. It would be more logical to either add an ionotropic agent that would improve cardiac performance through
Semiquinone Anion Radicals of Catechol(amine)s, Catechol Estrogens, and Their Metal Ion Complexes
Authors: B. Kalyanaraman, C. C. Felix, R. C. Sealy
Journal: Environmental Health Perspectives (1985)

The characterization and identification of semiquinone radicals from catechol(amine)s and catechol estrogens by electron spin resonance spectroscopy is addressed. The use of diamagnetic metal ions, especially Mg2+ and Zn2+ ions, to detect transient semiquinone radicals in biological systems and to monitor their reactions, is discussed. A brief account of the identification and reactions of quinones is also presented.
The Histamine and Insulin Treatment of Schizophrenia and Other Mental Diseases
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
NCI-U.S.—NCI-Milan Cooperation in Basic and Clinical Cancer Research
Journal: JNCI Journal of the National Cancer Institute (1985)

Journal Article NCI-U.S.—NCI-Milan Cooperation in Basic and Clinical Cancer Research Get access JNCI: Journal of the National Cancer Institute, Volume 74, Issue 1, January 1985, Page 265, https://doi.org/10.1093/jnci/74.1.265-d Published: 01 January 1985
William Crawford Gorgas and the American Medical Association
Authors: L. H. Ellman
Journal: JAMA (1980)

THE YEAR 1979 was the 125th anniversary of the birth of William Crawford Gorgas, MD (1854-1920). Best known for the eradication of yellow fever and the control of malaria in Havana and the Panama Canal Zone, Dr Gorgas also served as president of the American Medical Association in 1908 and surgeon general of the army during World War I. The AMA and the accomplishments of William Crawford Gorgas were intertwined on several occasions and deserve recounting. A major reason for the failure of the French to build an interoceanic canal in Panama in the 1880s and the major obstacle facing the American effort in 1904 were the presence of malaria and yellow fever, the two scourges of the American tropics. Although not universally recognized by the scientific community at the time of the US initiative in Panama, the source of both yellow fever and malaria had already been discovered. Ronald
Childhood lead poisoning in 1994
Authors: L. R. Goldman
Journal: JAMA (1994)

Lead poisoning is one of the worst environmental threats to children in the United States and is also entirely preventable.<sup>1</sup>An increased understanding of the adverse effects of lead poisoning—neurological, endocrinological, hematological, reproductive, and growth—resulted in the Centers for Disease Control and Prevention lowering the acceptable blood lead level three times in the last 20 years.<sup>2</sup> The article by Pirkle et al<sup>3</sup>documents the dramatic decrease in blood lead levels from 0.62 to 0.14 μmol/L (12.8 to 2.8 μg/dL) between 1976 to 1980 and 1988 to 1991. Most significantly, the percentage of US children aged 1 to 5 years with blood lead levels 0.48 μmol/L (10 μg/dL) or greater decreased from 88.2% to 8.9%. Decreases in blood lead levels occurred for all age and income groups. This is surely one of the most remarkable public health achievements of the decade and is undoubtedly the result of government
Laboratory Diagnostic Methods. Pathological, Bacteriological, Serological and Chemical. A Manual for Physicians, Medical Students and Laboratory Technicians.
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effects of Nonselective and Selective a,-Adrenergic Blockade on Coronary Blood Flow During Exercise
Authors: Robert J. Bache, Xue-Zheng Dai, Charles A. Herzog, Jeffrey S. Schwartz
Journal: Circulation Research (1987)

This study was made to evaluate the relative importance of o t r and a j -adrenergic vasoconstrictor influences in opposing the increase in coronary blood flow that occurs during exercise.The effects of selective o ^-adrenergic blockade with prazosln were compared with nonselective a-adrenergic blockade with phentolamine on coronary hemodynamics during exercise in chronically instrumented dogs.During control conditions, graded treadmill exercise resulted in progressive increases of myocardial oxygen consumption; this was associated with increased coronary blood flow as well as with increased myocardial oxygen extraction.Although prazosin and phentolamine caused similar reductions of arterial pressure, phentolamine increased heart rate, myocardial oxygen consumption, and coronary blood flow at equivalent exercise levels, and prazosin did not significantly alter these variables.These effects of phentolamine appeared to result from blockade of presynaptic o 2 -adrenergic receptors, which normally modulate norepinephrine release, that resulted in increased sympathetic effects on the heart.However, at comparable levels of myocardial oxygen consumption, prazosin and phentolamine resulted in similar significant increases of coronary venous Po 2 and decreases of coronary vascular resistance.These data support a modest role for a r adrenergic coronary vasoconstriction during exercise but fail to document an additional role for postsynaptic « 2 adrenergic coronary vasoconstriction during exercise.(Circulation Research 1987;61(suppl II):II-36-11-41)A lthough coronary blood flow is regulated princi-/\ pally in response to local myocardial meta-2.\ -bolic needs, sympathetic vasoconstrictor influences may restrain coronary vasodilation that occurs in response to increased myocardial metabolic demands. 1 -2 In chronically instrumented dogs, exercise has been shown to produce a greater increase in coronary blood flow after nonselective a-adrenergic blockade with phentolamine. 3" 5 The greater increase in coronary blood flow during exercise after phentolamine could result from two separate mechanisms.First, blockade of central presynaptic a 2 -adrenergic receptors interrupts the negative feedback control of norepinephrine release; the resultant increased /3-adrenergic stimulation could increase coronary blood flow secondary to increased myocardial oxygen consumption. 6econd, a-adrenergic blockade could increase coronary blood flow at any given level of myocardial oxygen consumption by interrupting postsynaptic vasoconstriction, which competes with metabolic vasodilator influences.
Clinical Gastroenterology
Authors: Richard V. Lee
Journal: JAMA (1977)

I can enthusiastically recommend the second edition of Spiro's book to any physician who is engaged in what Spiro calls "the finest calling in medicine," patient care. The author's approach is eminently practical, and the book is neatly organized into clinically important units. The second edition is about 250 pages longer than the first. There is a new unit that gathers together the inflammatory bowel diseases. The discussions about the irritable bowel, hiatus hernia, and esophageal reflux should be read by all family physicians and general internists. The introduction to the dietary instructions is a distillate of common sense and priestly sensibility about food. Recent advances in current practice are illustrated by discussions about the use of transhepatic cholangiography, endoscopic retrograde cholangiopancreatography, and ultrasound for the evaluation of biliary tract and pancreatic disorders. Spiro has changed his approach to certain problems. Five years ago, he favored bypass procedures for the
Wasp-Stings
Authors: C. D. H. Drury
Journal: BMJ (1871)

infiltation.No post mortem examination was had, in consequence of his residence being fifty miles distant from Aberdeen.CASE cxcviII.-JamesClarke, aged 55, nmason, came under treat- meat on March 6th, I865, and was operated on April Ist.The stone weighed 2 ounces iA drachms, and measured 21 inches by 2 itches by I inch.With a quiet pulse, and urine both clear and opious, he went on favourably for eight days, the tongue only being dry ; yet his desire for food was natural.On the ninth day, the pulse luickened a little; but there was no tenderness or local symptom any- where, and he still took his food.On the twelfth day, he became faint, after sitting up in bed; and, continuing feeble, he expired on the evening of the thirteenth day (April 13th).Inspection revealed a collection of thick pus in the cellular tissue around the wound and neck of the bladder.The viscera of the abdomen were quite healthy.The coats of the bladder were thick and chronically inflamed.CASE cciii.-DavidStewart, aged 79, farmer, was admitted on July 7th, i866, and was operated on July 14th, The stone weighed 71 drachms, and measured IA inches by i I inches by I inches.The patient was a large-built man, with a -deep perinaeum and a large carti- laginous prostate gland; yet the blunt gorget and chloroform made the
VLA Proteins In The Integrin Family: Structures, Functions, And Their Role On Leukocytes
Authors: M. Hemler
Journal: Annual Review of Immunology (1990)

Exhausted CD8 T (Tex) cells are a distinct cell lineage that arise during chronic infections and cancers in animal models and humans. Tex cells are characterized by progressive loss of effector functions, high and sustained inhibitory receptor expression, ...Read More
Bibliography of Cancer Produced by Pure Chemical Compounds
Journal: JNCI Journal of the National Cancer Institute (1960)

Journal Article Bibliography of Cancer Produced by Pure Chemical Compounds Get access JNCI: Journal of the National Cancer Institute, Volume 24, Issue 2, February 1960, Page 518, https://doi.org/10.1093/jnci/24.2.518 Published: 01 February 1960
Instruction Course Program
Authors: Kaz Soong, Roger Meyer, Alan Sugar, Ann Arbor, Eric Donnenfeld, Rockville Centre, M Dodick, New York, Pauls Koch, Robert Morris, Ferenc Kuhn, ; James Byrne, Douglas Witherspoon, Robert Osher, Richard Lindstrom, Douglas Koch, Roger Steinert, Ma Robert F Cionni, Samuel Masket, West Hills, Stephen Lichtenstein, Walter Stark, D Gottsch, T Holladay, Marguerite Mcdonald, New Orleans, La George, Waring Ill, Ga Akef, Julia Holler, Denis O'day, Arlo Terry, San Antonio, Stephen Obstbaum, Oliver Schein, Joseph Caprioli, New Haven, Robert Stamper, San Francisco, ; Charles, P Wilkinson, Mark Blumenkranz, Kenneth Hoffer, Santa Monica, Robert Snyder
Journal: Ophthalmology (1994)
Mucosectomie froide versus chaude pour polype non pédiculé colorectal de 6–10 mm: un essai randomisé
Journal: Endoscopy (2018)

La polypectomie à l’anse froide est une méthode validée pour l’exérèse de lésions de petite taille. L’objectif de cet essai bicentrique, randomisé et de non-infériorité était de comparer les mucosectomies coliques à l’anse froide et chaude pour les polypes non pédiculés, mesurant de 6 à 10 mm.
Metabolism and Toxicity of 2,2,2-Trifluoroethyl Vinyl Ether
Authors: Vera Fiserova-Bergerova
Journal: Environmental Health Perspectives (1977)

A review on metabolism and toxicity of the fluorinated anesthetic agent, fluroxene, is presented. Fluroxene anesthesia is nontoxic to man but fatal to many experimental animals. The fluroxene molecule (2,2,2-trifluroethyl vinyl ether) is composed of two moieties; both are toxic as a result of their metabolism: the vinyl moiety destroys heme of cytochrome P-450 while being metabolized to the final product, CO2. The trifluoroethyl moiety is oxidized to trifluoroethanol (TFE) and trifluoroacetic acid (TFAA), and the acute toxicity of fluroxene is related to this pathway. The ratio of metabolities (TFAA to TFE) excreted by different species exposed to fluroxene varies; whenever highly toxic TFE is the major metabolite, fluroxene toxicity is high (rodents, dogs, phenobarbital pretreated monkeys), whenever TFAA is the major metabolite (man, monkey) fluroxene is not toxic. Toxicity in different species also correlates with the extent of glutathione depletion following fluroxene exposure. Fluroxene metabolism and toxicity are modified by drugs metabolized by or affecting the activity of the microsomal cytochrome P-450-system or enzymes involved in ethanol metabolism. The susceptibility of fluroxene to two enzymatic systems which are modified by environmental and genetic factors may explain the large differences in fluroxene toxicity to various species. The fate of one-third of fluroxene administered to man remains unknown.
寻常天疱疮口腔疾病严重程度评分
Authors: M. Ormond, H. McParland, A.N.A. Donaldson, M. Andiappan, R.J. Cook, M. Escudier, E. Hullah, J. Higham, R. McMillan, J. Taylor, P.J. Shirlaw, S.J. Challacombe, J.F. Setterfield
Journal: British Journal of Dermatology (2018)

寻常天胞疮 (Pemphigus vulgaris, PV) 是一种罕见且通常严重的自身免疫性疾病,可在许多部位引起疼痛性水疱,包括皮肤、口腔、鼻腔、咽喉或生殖器。它通过产生针对皮肤或粘膜的有害抗体来做到这一点。口腔通常是该疾病开始的部位,并且可能持续多年受影响。免疫抑制药物可用于治疗 PV, 但为了有效和安全地使用这些药物,临床医生需要一种准确且“可重现”的方法来评估和记录病变的数量和部位。可重现意味着测试可以由另一个人重复进行,且结果将是相同的。因此需使用经过科学验证的评分工具,包括自身免疫性大疱性皮肤病强度评分 (ABSIS) 和天疱疮疾病区域指数 (PDAI) 。这些包括口腔(嘴部)成分,但对于以口腔疾病为主的患者,我们设计了一种特定的口腔疾病严重程度评分 (ODSS),该评分观察口腔中的 17 个部位,但使用起来快速且简单。在这项英国研究中,我们试图验证 ODSS 并将其重现性与 ABSIS、PDAI 和医生全球评估 (Physicians Global Assessment) 评分进行比较。十名口腔医学专家,其中大多数人不熟悉这些方法中的任何一种,每人在一天内对 15 名口腔 PV 患者进行了评分。两名医生对所有 15 名患者进行了重新评分。结果表明, ODSS 既可靠又可重现,并且用于评估口腔疾病至少与 ABSIS 和 PDAI 同样有效(如果不是更好)。通过提供更详细的评估口腔 PV 的方法,我们认为 ODSS 对于长期疾病监测将更加灵敏(准确)。
Comparison of Findings among Residents on Michigan Dairy Farms and Consumers of Produce Purchased from These Farms
Authors: Ruth Lilis, Henry A. Anderson, Jose A. Valciukas, Steven Freedman, Irving J. Selikoff
Journal: Environmental Health Perspectives (1978)

Consumers who had purchased farm products from both quarantined and nonquarantined farms were examined during the cross-sectional clinical survey of 1,029 Michigan residents. Since PBB had inadvertently contaminated cattle and other farm animals, ingestion of meat, milk, eggs and other farm products was thought to have possibly resulted in significant PBB body burdens in some consumers. Findings were considered in comparison with those made among farm residents. Prevalence of symptoms in consumers of farm products from quarantined farms (CQ) was similar to that found in farmers on quarantined farms (FQ); the prevalence was lower in consumers of products from nonquarantined farms (CNQ). Liver function abnormalities were found with similar prevalence in dairy farmers and consumers. Distribution, mean and median values of PBB serum levels in consumers were found to be similar to those of dairy farmers. These results indicate that significant body burdens of PBB had been accumulated by some consumers of farm products in Michigan and that prevalence of symptoms and liver function abnormalities resembled those found among dairy farm residents.
INPUT AND OUTPUT IN RENIN RELEASE
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Phase II Study of Pemetrexed in Chemotherapy-Naïve Elderly Patients with Advanced Non-Squamous Non-Small-Cell Lung Cancer: Hanshin Oncology Group 003
Authors: M. Iwasaku, Y. Hattori, S. Morita, H. Yoshioka, K. Otsuka, N. Katakami, S. Fujita, S. Yokota, F. Imamura, S. Negoro
Journal: Annals of Oncology (2012)