tbuckley/cabot-search huggingface dataset:
Presse Médicale, Paris
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Drug Combo Bests Sunitinib in RCC
Journal: Cancer Discovery (2018)

The phase III IMmotion151 trial found that the combination of atezolizumab and bevacizumab boosts progression-free survival compared with sunitinib in patients with advanced or metastatic renal cell carcinoma. The increase was 2.8 months in all patients and 3.5 months in patients with PD-L1-positive tumors.
Diazinon-Dimpylate
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BI25: Lessons learnt: our experience of a specialist surveillance dermatology clinic for immunosuppressed patients at a UK tertiary centre
Journal: British Journal of Dermatology (2021)

for diabetes and renal impairment were unremarkable.Further biopsies revealed shallow, cup-shaped disruptions of acanthotic epidermis with thick plugs of basophilic debris and collagen elimination to the surface, consistent with an acquired perforating dermatosis (APD).Prominent elimination of elastic fibres was also observed.Natalizumab was considered the most likely culprit, prompting a switch to ocrelizumab (anti-CD20 monoclonal antibody).Narrowband ultraviolet B therapy was started.Within 2 months, his skin demonstrated significant improvement.APD is typically associated with conditions such as diabetes, renal impairment, malignancies and, more rarely, drugs.We herein present a case of natalizumab-induced APD, which adds to the list of recognized skin complications from natalizumab, including alopecia, urticaria and flushing.To date, there has been one other case report of natalizumab-induced APD (Piqu e-Duran E, Egu ıa P, Garc ıa-V azquez O. Acquired perforating dermatosis associated with natalizumab.J Am Acad Dermatol 2013; 68: e185-7).APD has been reported to relate to other biologics, which have a variety of therapeutic targets.The mechanism by which these monoclonal antibodies contribute to a perforating dermatosis is unknown.Medication-associated APD is most commonly found in men over 50 years of age, with the development of this skin condition typically within months of treatment onset.Our patient uniquely extends this time window to 5 years.Histologically, biological therapy-induced APD features perforation of collagen alone, compared with our case, which showed perforation of both collagen and elastic fibres.Natalizumab-induced APD should be considered in people with RRMS who present with pruritic eczematous eruptions, irrespective of the duration of therapy.
PET/CT allows for a reliable assessment of the real nodal burden in clinically node-positive prostate cancer patients candidate for radical prostatectomy: Results from a multi-institutional series
Authors: G. Gandaglia, R.J. Karnes, C. Berghen, W. Everaerts, G. Devos, S. Joniau, D. Robesti, A. Stabile, S. Scuderi, F. Barletta, V. Cucchiara, E. Mazzone, G. Rosiello, A. Salonia, P.I. Karakiewicz, H. Van Poppel, F. Montorsi, A. Briganti
Journal: European Urology (2021)
North of England evidence based guidelines development project: summary version of evidence based guideline for the primary care management of asthma in adults
Authors: None Given
Journal: BMJ (1996)

The aim of this guideline is to provide recommendations (evidence based when possible) to guide primary health care professionals in their management of adult patients with asthma. It is a summary version of the full guideline,1 to which reference should be made for clarification or further information. The development group assumes that health care professionals will use general medical knowledge and clinical judgment in applying the general principles and specific recommendations in this document to the management of individual patients. Recommendations may not be appropriate for use in all circumstances. Decisions to adopt any particular recommendation must be made by the practitioner in the light of available resources and circumstances presented by individual patients. Throughout this guideline categories of evidence (cited as I, II, and III) and the strength of recommendations (A, B, or C) are as described in the first article in the series.2 Aspects covered by the guideline are the use of peak flow measurement in diagnosis and management, drug treatment, non-drug treatment, and referral. All recommendations are for primary health care professionals and apply to adult patients attending general practice with asthma. Comment—British Thoracic Society guidelines state the aims of treatment as patients having the least possible symptoms; the least possible need for relieving bronchodilators; the least possible limitation of activity; the least possible circadian variation in peak flow; the least possible adverse effects from medicine; and the best peak flow possible.3 It is preferable to adjust treatment to cover exposure to day to day triggers such as exercise and cold air because avoidance imposes inappropriate restrictions on lifestyle. Specific comments about adjusting the dosages of drugs are made within the relevant sections on drug treatment.
Early maternal hypothyroxinemia alters histogenesis and cerebral cortex cytoarchitecture of the progeny
Authors: Rosalía Lavado-Autric, Eva Ausó, José Victor García-Velasco, María del Carmen Arufe, Francisco Escobar del Rey, Pere Berbel, Gabriella Morreale de Escobar
Journal: Journal of Clinical Investigation (2003)

Epidemiological studies from both iodine-sufficient and -deficient human populations strongly suggest that early maternal hypothyroxinemia (i.e., low circulating free thyroxine before onset of fetal thyroid function at midgestation) increases the risk of neurodevelopmental deficits of the fetus, whether or not the mother is clinically hypothyroid. Rat dams on a low iodine intake are hypothyroxinemic without being clinically hypothyroid because, as occurs in pregnant women, their circulating 3,5,3′-triiodothyronine level is usually normal. We studied cell migration and cytoarchitecture in the somatosensory cortex and hippocampus of the 40-day-old progeny of the iodine-deficient dams and found a significant proportion of cells at locations that were aberrant or inappropriate with respect to their birth date. Most of these cells were neurons, as assessed by single- and double-label immunostaining. The cytoarchitecture of the somatosensory cortex and hippocampus was also affected, layering was blurred, and, in the cortex, normal barrels were not formed. We believe that this is the first direct evidence of an alteration in fetal brain histogenesis and cytoarchitecture that could only be related to early maternal hypothyroxinemia. This condition may be 150–200 times more common than congenital hypothyroidism and ought to be prevented both by mass screening of free thyroxine in early pregnancy and by early iodine supplementation to avoid iodine deficiency, however mild.
Error in Text
Authors: Michael Yokell, Scb Delgado, Nickolas Zaller, N Wang, Samuel Mcgowan, Traci Craig Green
Journal: JAMA Internal Medicine (2014)

Jennifer Tjia, MD, MSCE; Becky A. Briesacher, PhD; Daniel Peterson, MA; Qin Liu, MD, PhD; Susan E. Andrade, ScD; Susan L. Mitchell, MD, MPH
Diabetes insipidus
Authors: R. Utiger
Journal: JAMA (1969)

Dr. Philip Lebovitz, Junior Assistant Resident in Medicine, Jewish Hospital of St. Louis and Assistant in Medicine, Washington University School of Medicine: A 62-year-old white man was hospitalized on March 27, 1968, because of increasing exertional dyspnea of two weeks' duration. Thirty years previously a diagnosis of rheumatic heart disease with atrial fibrillation had been made. In 1953, following a pulmonary embolus, the patient was treated with warfarin sodium for several months. In 1956 the patient was given digoxin and in 1964 chlorothiazide. Three months before hospitalization furosemide was substituted for chlorothiazide. One month later the patient noticed increasing thirst, a craving for ice water, polyuria, and nocturia. There was no chest pain, cough, hemoptysis, syncope, orthopnea, paroxysmal nocturnal dyspnea, headache, vertigo, or visual disturbance. A stone in the left kidney was removed surgically 12 years before admission and nine years later a suprapubic prostatectomy was performed. Physical examination revealed
Androgen Metabolism
Authors: Mortimer B. Lipsett, Stanley G. Korenman
Journal: JAMA (1964)

THE TERM "ANDROGEN" operationally defines a class of substances that possess certain biological activities. Among these activities are the maintenance of the structure and function of the prostate and seminal vesicles, production of the pattern of sexual hair growth characteristic of the male, increase in the sex drive of the male animal, and promotion of muscular development. Many synthetic steroids have all of these properties and are therefore androgens. Although several naturally occurring steroids are androgenic in varying degrees, depending on the bioassay system used, it is the present consensus that the physiologically important androgen in man is testosterone. The introduction of new analytical methods has resulted in a rapid expansion of our knowledge of testosterone metabolism. We shall summarize these data and try to focus current concepts on problems in clinical medicine. We have limited this discussion to studies in man and a few relevant experiments with animals. For
Interstate Reciprocity and Frauds in Medical Schools.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Familial Occurrence of Infantile Cortical Hyperostosis
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Liver: Morphology, Biochemistry, Physiology. Vol 1
Authors: F. W. Hoffbauer
Journal: JAMA (1964)

This volume, the first of two, contains 11 chapters prepared by 14 contributors. It deals in comprehensive manner with the embryology, gross, microscopic, and ultramicroscopic morphology of the liver, and certain aspects of physiology and biochemistry. The editor is an outstanding histologist and pioneer in the study of the ultrastructure of the liver. He has selected authoritative investigators in the preclinical sciences, half from this continent and half from European centers, to present extensive reviews with emphasis on recent developments in given areas. Each section represents a separate entity. There is very little repetition; the material has been carefully edited. The initial chapter on embryology of the liver is informative and the translation to English is excellent. Two chapters deal with anatomy. That by A. M. Rappaport discusses the acinar concept and its application to the structural alterations seen in the various forms of cirrhosis. An extensive review of the
THE LUNG COMPLICATIONS OF APPENDICITIS.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Physiology
Authors: Hebbel E. Hoff, H. J. Scott
Journal: New England Journal of Medicine (1948)

Special Circulations The Liver The unusual nature of the hepatic circulation has been emphasized by recently acquired evidence103 that the oxygen supply to the liver may constitute the dominant factor determining whether shock becomes irreversible. It has been stated that the liver depends in large measure on portal blood for its oxygen,104 and that increasing the oxygen content of portal blood by transfusion of arterial blood into the portal circulation protects the recipient against death from shock.105 This view is in keeping with the classic anatomic opinion that the portal circulation is the major source of blood for the liver . . .
The Cliché
Authors: Charles G. Roland
Journal: JAMA (1967)

What is a cliché? Most dictionaries provide only cursory and unsatisfactory definitions, and the<i>Oxford English Dictionary</i>, generally considered the most complete and authoritative of modern dictionaries, does not define "cliché" as a grammatical term. To say that a cliché is a trite or hackneyed phrase is not to make much progress, for then we must define "trite" and "hackneyed." And even when this is done, how much more do we know about the cliché? I consider a cliché to be a word or phrase which has become trite or hackneyed within a certain context, and according to a majority of auditors or readers. When first used, a cliché may have been an especially apt way of expressing a thought; whether this is true or not, it represents a formula, or an automatic response or expression. There are several categories of clichés. After separating those which are quotations from those
Pancytopenia following low-dose methotrexate therapy
Authors: E. A. Abel
Journal: JAMA (1988)

Drs Shupack and Webster<sup>1</sup>have refreshed our awareness of the risk-benefit considerations for methotrexate therapy for nononcological disorders by means of their pertinent and timely description, in this issue ofTHE JOURNAL, of two patients who developed pancytopenia following low-dose methotrexate therapy for psoriasis. Six additional cases of methotrexate-related bone marrow suppression<sup>2</sup>are also reviewed. Their report is particularly relevant in view of the See also p 3594. increasing use of methotrexate therapy for rheumatoid arthritis<sup>3,4</sup>and extra-articular manifestations of rheumatoid arthritis, including vasculitis.<sup>5</sup>In addition, low-dose methotrexate has been investigated as a steroid-sparing agent in patients with severe asthma.<sup>6</sup> Methotrexate is a highly effective therapy for patients with severe disabling psoriasis that is resistant to conventional topical therapy and photochemotherapy with methoxsalen and ultraviolet-A irradiation (PUVA). The drug is administered orally or intramuscularly in a weekly dosage of 7.5 to 15 mg. As a
Frequent detection of hepatitis A viral RNA in serum during the early convalescent phase of acute hepatitis A
Authors: K Fujiwara, O Yokosuka, T Ehata, F Imazeki, H Saisho, M Miki, M Omata
Journal: Hepatology (1997)

The diagnosis of type A hepatitis is performed mainly by immunoglobulin M (IgM) anti-hepatitis A antibody assay, but it has not been established whether there is a correlation between changes in viremia and the clinical course of type A hepatitis. We examined hepatitis A virus (HAV) RNA in the sera from type A and non-A, non-B, non-C acute hepatitis and analyzed the relation of HAV viremia with alanine aminotransferase (ALT) and IgM-HA levels. Two hundred sera from 38 patients with type A acute hepatitis and 20 patients with non-A, non-B, non-C acute hepatitis were examined for the presence of HAV RNA. HAV RNA was detected by nested reverse transcription-polymerase chain reaction (RT-PCR) with primers located at the 5′ non-translated region of HAV. HAV RNA was detected in 35 of 38 (92%) type A hepatitis patients and in 60 of 156 (38%) serum samples. In contrast, it was detected in none of 44 serum specimens from 20 non-A, non-B, non-C acute hepatitis patients. In type A hepatitis, the mean ALT level in HAV RNA positive specimens was 1,481 ± 2,042 (range, 20-10,370) IU/L and that in HAV RNA negative specimens 186 ± 330 (range, 8-1,698). The positivity of HAV RNA was correlated with the level of transaminase at the time of sample collection. The mean duration from the onset of symptoms to disappearance of HAV RNA was 18 ± 14 days. The mean titer of IgM-HA in HAV RNA positive cases was 5.0 ± 1.4, in negative cases 5.7 ± 1.1, with no statistical difference. Our results indicate that HAV RNA in serum is detectable in the majority of type A hepatitis cases in their early convalescent phase by nested RT-PCR.
Retrieval of fragmented pacemaker catheter from the heart
Authors: K. R. Falchuk
Journal: JAMA (1969)

<h3>To the Editor:—</h3> Levodopa and 5-hydroxytryptophan have been reported to be of benefit to people with Parkison's disease, and 2-amino-4-hydroxy - 6 - 7 - dimethyltetrahydropteridine has been found to be a cofactor required by tryptophan and tyrosin hydroxylase (Hosada, A., and Glick, D.:<i>J Biol Chem</i><b>241</b>:192, 1966; Nagatin, F., et al:<i>J Biol Chem</i><b>239</b>: 2810, 1964). It has been suggested that this co-factor may be deficient in people with Parkinson's disease (Kuehl, et al:<i>Nature</i><b>217</b>:1368, 1967). Wouldn't this cofactor be a likely prospect as a drug for parkinsonism?
School pregnancies.
Journal: BMJ (1980)

School pregnanciesFrom 1974 to 1976 in England and Wales 14 739 school- girls below the age of 16 became pregnant and 10 273 of these pregnancies were legally terminated.' 2 Against the 1 740 000 births and 317 000 legal abortions that took place nationally during the same period these numbers seem small.Never- theless, the problems that stem from pregnancy at such an early age are especially distressing for the girl, for her family, and for those in the medical, social, and educational services who have to deal with the immediate and long-term effects.Some of the consequences are well established; information on others-many others-is either scanty or non-existent.Compared with older teenagers and women up to the age of 35, these young girls are more likely to have complicated pregnancies: morbidity and mortality rates are higher for the young mothers and their babies.3 8Both social deprivation and physical and psychological immaturity are likely to play some part in this poor reproductive performance, but the relative importance of each is uncertain.National figures show that gynaecologists tend to terminate most of the pregnancies, but one difficulty is that the very young often delay their request for abortion.In 1968 and 1969-immediately after the Abortion Act-49% of the abortions carried out on girls under the age of 16 were beyond 13 weeks' gestation; the comparable figure for girls aged 16 to 19 was 40%.By 1975 the figures had dropped respectively to 30% and 25%.9This trend towards earlier termination in