tbuckley/cabot-search huggingface dataset:
Oncology
Authors: Mace Rothenberg
Journal: JAMA (1990)

Over the past few years, advances have been made in the prevention, detection, and treatment of many of the most common cancers. Some of these advances have direct clinical application and are expected to save or lengthen the lives of thousands of patients with cancer each year. Important achievements have been made in the laboratory as well, where scientists have gained valuable insight into the molecular and genetic events that cause malignant transformation of normal cells. It is likely that the practice of oncology in the 1990s will incorporate much of this knowledge into the optimal treatment of patients with cancer. Colon cancer strikes about 110 000 individuals per year in the United States.<sup>1</sup>Of these, approximately 21000 have tumor that involves regional lymph nodes (ie, Dukes' stage C) at the time of diagnosis. Although all visible tumor may be removed by surgery, 50% to 60% of individuals with
Quantitative and Molecular Analyses of Genetic Risk: A Study with Ionizing Radiation
Authors: A. W. Hsie, Z. Xu, Y. Yu, J. An, M. L. Meltz, J. L. Schwartz, P. Hrelia
Journal: Environmental Health Perspectives (1993)

Mammalian cells in culture have been used to study the genetic effects of physical and chemical agents.We have used Chinese hamster ovary (CHO) cells, clone K1-BH4, to quantify mutations at the X-linked, large (35 kb) hypoxanthine-guanine phosphoribosyltransferase (hprt) locus (the CHO/HPRT assay) induced by environmental agents.By transfecting an hprt-deletion mutant CHO cell line with the plasmid vector pSV2gpt, we isolated a transformant, AS52.AS52 cells carry a single functional copy of an autosomal, small (456 bp) xanthine-guanine phosphoribosyltransferase (gpt) gene (the bacterial equivalent of the mammalian hprt gene; AS52/GPT assay).We found that ionizing radiations such as X-rays and neutrons and oxidative genotoxic chemicals such as Adriamycin, bleomycin, hydrogen peroxide, and potassium superoxide are much more mutagenic to the gpt gene in AS52 cells than to the hprt locus in K1-BH4 cells.The hypermutability of the gpt gene probably results from a higher recovery of multilocus deletion mutants in AS52 cells than in K1-BH4 cells, rather than a higher yield of induced mutants.These results demonstrate that the use of the hprt locus alone could lead to an underestimate of the genetic risk of these agents.Analyses of the mutation spectrum using a polymerase chain reaction-based deletion screening and DNA sequencing procedure showed that a high proportion of HPRT-and GPTmutants induced by X-rays carry deletion mutations.Thus, both the mutant frequency and mutation spectrum need to be considered in assessing the genetic risk of ionizing radiation and oxidative genotoxic chemicals.
Bureau of Investigation
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Helminthic Infections Among Peace Corps Volunteers in Nepal
Authors: Eli Schwartz
Journal: JAMA (1990)

<h3>To the Editor.—</h3> From February 1986 to December 1987 our clinic analyzed stool specimens from 209 Peace Corps volunteers. Volunteers are posted to villages in rural areas throughout Nepal. Most volunteers spend 27 months in the country. Approximately 30% live in the Terai (subtropical lowlands) and the rest live in the middle hill region of the country. The predominant illness in volunteers is diarrheal disease, which accounts for more than 50% of clinic visits. In this study, we estimated the prevalence of helminthic infection and reviewed the length of time in the country prior to infection. <h3>Study.—</h3> A total of 209 volunteers submitted 994 specimens during their tours. Forty-one specimens were positive for helminths, 2 of which represented recurrent infections. There were no mixed helminthic infections, although helminths were found in association with other pathogens in 8 samples. Of the 209 volunteers, 29 (14%) had positive stool samples for
Carcinoma in situ of the genitalia
Authors: M. E. Bender
Journal: JAMA (1980)

THE incidence of carcinoma in situ (CIS) of the genitalia either is increasing or is being diagnosed more frequently. It may resemble a variety of benign cutaneous abnormalities, and the clinician may not appreciate the malignant biological features of these lesions unless a biopsy is performed. We describe the multiple clinical appearances of CIS occurring on the male and female genitalia. We describe the clinical features of 19 cases and review the relevant literature on this subject. <h3>Patients and Methods</h3> The 19 patients reported in this series were seen for diagnosis and treatment of cutaneous genital lesions. The relevant clinical data are summarized in the Table. All patients had biopsy confirmation of CIS made by light microscopy. The histologic diagnosis of CIS was made by consulting dermatopathologists and pathologists. Prior to diagnosis, several of our referred patients were thought to have condyloma acuminata, dermatitis, lichen planus, or other dermatoses that
Subscribers.
Journal: JAMA (1884)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
LECTURE.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Gaspare Tagliacozzi (1545-1599) Plastic Surgeon
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Text-Book of Embryology.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE THEORIES OF ECTOPIC PREGNANCY.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
No Fun in the Sun
Journal: Environmental Health Perspectives (1994)

II I I determined.The treaty signers will meet later this year to discuss this and other problems that have already surfaced.One such problem is that there is considerable scientific uncertainty as to how, or if, many species can even be saved.Another problem is how to balance access to genetic material with biotechnology profits.The treaty signers also face questions about how the treaty will be financed, how the technology will be shared, and how the permanent secretariat will be established.The treaty became legally binding after the 30th signer, Mongolia, ratified it.Among the other countries that have ratified the treaty are industrialized nations such as Canada, Japan, Norway, and Australia, and a number of developing countries such as Uganda, Nepal, the Philippines, and Ecuador."I think its worth remarking that the first 30 ratifications came overwhelmingly from the lower-income countries," Angela Cropper of Trinidad and Tobago, executive secre- tary of the treaty's interim secretariat, told the The New York Times."Biological diver- sity-our food and medicines as well as the treasure house of animals and plantscome mainly from the tropical and devel- oping nations.If we want to continue to profit from this wealth, we must make it worthwhile for poor countries to protect this heritage," she said.
RAPIER DUELING AND SURGERY
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hyperkinetic Adult
Authors: L. Eugene Arnold
Journal: JAMA (1972)

A form of the hyperkinetic syndrome, assumed to be a juvenile condition, has been found in an adult with a previously undiagnosed condition. The pathognomonic paradoxical calming of the hyperkinetic by amphetamine was shown in a 22-year-old man and further elucidated by quantitative self-estimation of mood following doubleblind administrations of dextroamphetamine sulfate and placebo. Compared to his response to placebo, he not only showed externally visible calming and depression, but also subjectively reported decreased anxiety, increased depression, and increased concentration, with no change in self-esteem.
Fleas, Flukes &amp;amp; Cuckoos: A Study of Bird Parasites.
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Vesiculobullous skin disease with prominent immunologic feature
Authors: L. E. Millikan
Journal: JAMA (1987)

WISE et al<sup>1</sup>first explored the realm of cutaneous immunofluorescence in 1962. After these initial steps, the landmark work of Beutner and Jordon<sup>2</sup>in the early '60s rapidly moved forward the diagnostic utility of cutaneous immunofluorescence and advanced our knowledge of the various vesiculobullous skin diseases, in which immunoreactants are demonstrated and thought to play a significant role. Even more sophisticated techniques have been developed that now provide remarkable insight into the anatomy of the dermal-epidermal structures and their interface and also provide insight into pathogenesis of these diseases and therapeutic potential for them. Since the last review of this situation in 1982, many advances have occurred in our understanding of the dermal-epidermal interface and pathophysiology of the mechanobullous or vesiculobullous diseases. This section updates our understanding of diseases previously covered (pemphigus, pemphigoid, dermatitis herpetiformis, chronic bullous dermatosis of childhood, and herpes gestationis) and adds an overview of
PNEUMOCOCCUS HEMOTOXIN
Authors: Rufus Cole
Journal: The Journal of Experimental Medicine (1914)

Solutions of the bodies of pneumococci, obtained by dissolving them in dilute solutions of sodium cholate, by permitting them to undergo autolysis, or by first freezing, drying, and then grinding in salt solution, are actively hemolytic for rabbit, sheep, guinea pig, and human red blood corpuscles. The substance on which this hemolytic property depends is very labile, much of its activity is lost on passing through a filter, and it is destroyed by the action of trypsin. In its properties it corresponds to the substance contained in such solutions which causes the death of guinea pigs on intravenous injection. Its activity is prevented by the presence of minute amounts of cholesterin. Following the injection of this solution into rabbits and sheep, the sera of these animals acquire increased power of inhibiting its hemolytic action. It therefore possesses antigenic properties. It may therefore be concluded that the bodies of pneumococci contain a toxin that is hemolytic for red blood corpuscles. This substance is not simply a product of autolysis but undoubtedly exists preformed in the bacterial cell. However, it is not given up to the surrounding fluid as long as the bodies of the bacteria are intact. It may therefore be considered a hemolytic endotoxin.
Update: Hantavirus Disease— Southwestern United States, 1993
Journal: JAMA (1993)

Since May 1993, the state health departments in Arizona, Colorado, New Mexico, and Utah; the Indian Health Service; and CDC, with the assistance of the Navajo Nation Division of Health, have been investigating an outbreak of acute respiratory illness related to a newly recognized hantavirus (1-5). This report updates the investigation and presents information on a recent case of hantavirus-associated respiratory disease in a resident of Nevada.
Nutrition and Physical Activity During and After Cancer Treatment: An American Cancer Society Guide for Informed Choices
Authors: J. K. Brown, T. Byers, C. Doyle, K. S. Courneya, W. Demark-Wahnefried, L. H. Kushi, A. McTiernan, C. L. Rock, N. Aziz, A. S. Bloch, B. Eldridge, K. Hamilton, C. Katzin, A. Koonce, J. Main, C. Mobley, M. E. Morra, M. S. Pierce, K. A. Sawyer
Journal: CA A Cancer Journal for Clinicians (2003)

Cancer survivors are often highly motivated to seek information about food choices, physical activity, dietary supplement use, and complementary nutritional therapies to improve their treatment outcomes, quality of life, and survival. To address these concerns, the American Cancer Society (ACS) convened a group of experts in nutrition, physical activity, and cancer to evaluate the scientific evidence and best clinical practices related to optimal nutrition and physical activity after the diagnosis of cancer. This report summarizes their findings and is intended to present health care providers with the best possible information on which to help cancer survivors and their families make informed choices related to nutrition and physical activity. The report discusses nutrition and physical activity issues during the phases of cancer treatment and recovery, living after recovery from treatment, and living with advanced cancer; selected nutritional and physical activity issues such as body weight, food choices, and complementary and alternative nutritional options; and selected issues related to breast, colorectal, lung, prostate, head and neck, and upper gastrointestinal cancers. In addition, handouts containing commonly asked questions and answers and a resource list are provided for survivors and families. Tables that grade the scientific evidence for benefit versus harm related to nutrition and physical activity for breast, colorectal, lung, and prostate cancers are also included for this growing body of knowledge to provide guidance for informed decision making and to identify areas for future research.
Polypoid mass in the stomach
Authors: R. A. Seltzer
Journal: JAMA (1965)

<h3>Dr. Donald L. Stone:</h3> This upper-gastrointestinal series is that of a 46-year-old white woman who had experienced some occasional epigastric discomfort for one year, and more recently had been noted to be somewhat pale. She had lost 5 lb (2.3 kg) over the two months prior to this examination. Laboratory data included a guaiac test of the stool which was 2 + and a hemoglobin level of 10.2 gm/100 cc. <h3>Discussion</h3><h3>Dr. Laurence L. Robbins:</h3> Is the fluoroscopist here? <h3>Dr. Willard Perry:</h3> I examined this patient and found a large radiolucent filling defect in the antral portion of the stomach (Fig 1,<i>left</i>). It seemed to vary in size and shape with peristaltic activity (Fig 1,<i>right</i>). It appeared to be on a stalk, but it did not prolapse into the duodenum. I thought a gastric polyp was the most likely diagnosis, although I also suggested a lipoma because of the