tbuckley/cabot-search huggingface dataset:
Botulism Associated With Commercially Canned Chili Sauce—Texas and Indiana, July 2007
Journal: JAMA (2007)

On July 7 and July 11, 2007, public health officials in Texas and Indiana, respectively, reported to CDC four suspected cases of foodborne botulism, two in each state. Investigations conducted by state and local health departments revealed that all four patients had eaten brands of Castleberry's hot dog chili sauce before illness began. Botulinum toxin type A was detected in the serum of one Indiana patient and in a leftover chili mixture obtained from his home. CDC informed the Food and Drug Administration (FDA) of the apparent link between illness and consumption of the chili sauce. On July 18, FDA issued a consumer advisory, and the manufacturer, Castleberry's Food Company (Augusta, Georgia), subsequently recalled the implicated brand and several other products produced in the same set of retorts (commercial-scale pressure cookers for processing canned foods) at the same canning facility. Examination of the canning facility in Georgia during the outbreak investigation had identified deficiencies in the canning process. On July 19, the U.S. Department of Agriculture Food Safety and Inspection Service (FSIS) issued a press release that announced a recall of chili and certain meat products from the Castleberry canning facility and provided recommendations to consumers. That recall was expanded on July 21 to include additional canned products. A fifth case of botulism potentially linked to one of the recalled products is under investigation in California. This report describes the ongoing investigation by members of OutbreakNet and others and the measures undertaken to control the outbreak, which is the first outbreak of foodborne botulism in the United States associated with a commercial canning facility in approximately 30 years. Clinicians should be vigilant for symptoms of botulism, including symmetric cranial nerve palsies, especially if accompanied by descending flaccid paralysis. Consumers should not eat any of the recalled chili sauce or other recalled products and should carefully dispose of all recalled products. Information regarding product disposal is available at http://www.cdc.gov/botulism/botulism_faq.htm.
Vigilance Needed to Diagnose, Treat Dengue Virus Infection
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Suramin therapy in AIDS and related disorders. Report of the US Suramin Working Group
Authors: B. D. Cheson
Journal: JAMA (1987)

Suramin sodium is a reverse transcriptase inhibitor with in vitro activity against the human immunodeficiency virus (HIV), the causative agent of acquired immunodeficiency syndrome (AIDS). Ninety-eight patients with AIDS manifest as opportunistic infections (n = 38), AIDS with Kaposi's sarcoma (n = 38), AIDS-related complex (n = 20), or AIDS-associated non-Hodgkin's lymphoma (NHL) (n = 2) were treated with suramin sodium at 0.5,1.0, or 1.5 g/wk for six weeks followed by maintenance therapy with 0.5 or 1.0 g/wk. Of 72 patients who were HIV culture positive before therapy and were assessable for subsequent HIV culture 40% became culture negative during treatment, with no apparent correlation between virus recovery and serum suramin concentration. No immunologic improvement was noted. One complete clinical remission was noted in a patient with Kaposi's sarcoma and stage IV NHL. Seven minor clinical responses were also noted. Toxic reactions were generally reversible, and included fever (78%), rash (48%), malaise (43%), nausea (34%), neurologic symptoms (33%), and vomiting (20%). Suramin-induced neutropenia was noted in 26%, thrombocytopenia in 12%, a serum creatinine level of 180 μmol/L or higher (≥2.1 mg/dL) in 12%, liver dysfunction in 14%, and clinical and/or laboratory evidence of adrenal insufficiency in 23%. Sixteen patients died while receiving suramin or within three weeks of discontinuation of drug therapy due to infection (n = 6), hepatic failure (n = 3), pulmonary Kaposi's sarcoma (n = 2), AIDS encephalitis (n = 2), AIDS-associated NHL (n = 1), iatrogenic hemopneumothorax (n = 1), or pulmonary disease of uncertain etiology. Suramin as currently administered cannot be recommended as effective therapy for AIDS. (<i>JAMA</i>1987;258:1347-1351)
Letter: Poisoned children.
Authors: J Linde, K Siersbmk-Nielsen, J Hansen, V Fuglsang-Frederiksen, C Munk, J Hulf, Ian Corall, Leo Strunin, K Knights, J Newton
Journal: BMJ (1975)

Anticonvulsant Osteomalacia and Vitaniln D SIR,--Controversial data concerning the effect of vitamin D on anticonvulsant osteomalacia have recently been reported in the B.M.7.1-3In 1971 we reported a preliminary study using photon absorptiometry in which we found de- creased bone mineral content (B.M.C.), decreased serum calcium values, and increased alkaline phosphatase activity in nine epileptic patients treated with anticonvulsants as compared with 10 psychiatric patients resident in the same epileptic colony.4 5 Six months' treatment with 50 000 IU vitamin D2 daily was unable to affect the mean values of B.M.C. in any of the groups.6In the following year both groups were given a reduced dose of 2400 IU vitamin D2 daily without dietary calcium supplements, but the B.M.C. values re- mained constant.In the following six months a dietary calcium supplement of calcium lactate 3 g/day was added to the vitamin D treatment, B.M.C. values remaining unaltered.The serum calcium values gradually returned to normal and have remained normal since the eighth month of vitamin D treatment.Serum alkaline phosphatase levels remained elevated in the epileptic patients during the whole period of treatment.Our results of long-term treatment with varying doses of vitamin D and calcium intake in a small group of epileptic patients are in some respects in disagreement with those of Clristiansen et al.,' who were able to demonstrate a 4% increase in B.M.C. following three months' treatment with 2000 IU vitamin D2 and calcium supplements in a large group of epileptics.Our finding of unaltered serum alkaline phosphatase values for more than two years of treatment seem to support the assumption of Rowe and Stamp2 that the elevated levels in adult epileptics are mainly due to increase in the hepatic isoenzyme.We have been unable to relate variations in serum calcium to B.M.C. values, but we agree with the statement of Christiansen et al. that prophylactic vitamin D supplements might prove to be beneficial to antiepileptic- treated patients.-Weare, etc.,
Sclerotic lesion in the right sphenoid wings
Authors: R. G. Ware
Journal: JAMA (1966)

Dr. Bruce J. Haskin: A 23-year-old woman was admitted for evaluation of right exophthalmos. During the five months before admission she had noted progressive discomfort behind her right eye. Protrusion of the eye developed with intermittent blurring of vision. She was seven months pregnant. Except for the enlarged uterus and the proptosis, the results of her general physical examination were unremarkable. There was blurring of the right nasal disk margin, but the visual fields were full. The remainder of the neurological examination was within normal limits. The roentgenographic examination of the skull (Figure) showed marked sclerosis of the greater wing of the right sphenoid and moderate sclerosis of the lesser sphenoid wing. There was narrowing of the right superior orbital fissure. It was thought that the lambdoid suture and the convolutional impressions were prominent, raising the question of increased intracranial pressure. <h3>Discussion</h3> Dr. Laurence L. Robbins: Dr. Dreyfuss, what are
Early clinical signs identify low-risk patients with acute upper gastrointestinal hemorrhage
Authors: D. R. Bordley
Journal: JAMA (1985)

Early identification of patients at low risk for poor outcome after acute upper gastrointestinal hemorrhage would allow reduction of diagnostic and therapeutic interventions. We identified six early predictors of good outcome: age less than 75 years, no unstable comorbid illness, no ascites found on physical examination, normal prothrombin time, and, within an hour after presentation, systolic blood pressure of 100 mm Hg or greater and nasogastric aspirate free of fresh blood. Presence of all six predictors defined the low-risk population. Among 162 patients in the development and retrospective validation phases of our study, all 74 low-risk patients had good outcomes. A prospective validation study of 111 patients further established the accuracy of our predictive method; only two of 52 low-risk patients had poor outcomes. Application of our method should allow more selective management of patients with acute upper gastrointestinal hemorrhage. (<i>JAMA</i>1985;253:3282-3285)
SERUM BICARBONATE IN ACUTE HEART FAILURE: RELATIONSHIP TO TREATMENT STRATEGIES AND CLINICAL OUTCOMES
Authors: Lauren Cooper, Robert Mentz, Dianne Gallup, Anuradha (Anu) Lala-Trindade, Justin Vader, Omar AbouEzzeddine, Javed Butler, Bradley Bart, Horng Chen, Margaret Redfield, Lynne Stevenson, Christopher O’Connor, Kevin Anstrom, Adrian Hernandez, G. Michael Felker
Journal: Journal of the American College of Cardiology (2015)
The Pathogenesis of Congenital Cardiovascular Anomalies
Authors: Benjamin T. Jackson
Journal: New England Journal of Medicine (1968)

MOST congenital cardiovascular anomalies have their genesis early in gestation while the individual organs or organ systems are being formed within the embryo. A number of such anomalies are clearly of genetic origin, resulting from either familial inheritance or chromosomal aberrations. Specific environmental influences are of primary significance as the causative factors in an additional number. For the majority of cases of congenital heart disease, however, no clear-cut etiologic basis has been established. A number of authors have speculated that a large percentage of congenital cardiovascular anomalies are the result of varied environmental factors acting in persons with genetic tendencies . . .
Minerva Medica, Turin
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diarrheal deaths in American children. Are they preventable?
Authors: M S Ho, R I Glass, P F Pinsky, N C Young-Okoh, W M Sappenfield, J W Buehler, N Gunter, L J Anderson
Journal: JAMA (1988)

We reviewed national mortality data for 1973 through 1983 to assess the importance of diarrheal diseases as a cause of preventable childhood death in the United States. An average of 500 children aged 1 month to 4 years died each year with diarrhea reported as the cause of death. These diarrheal deaths were most common among children who were younger than 1 year of age, black, and living in the South, and were most common during the winter. In Mississippi, review of fatal cases of diarrhea identified maternal factors--black race, young age, unmarried status, low level of education, and little prenatal care--to be most associated with diarrheal death in the child. Fifty percent of these deaths occurred after a child had reached a medical facility. Our findings suggest that diarrheal deaths may be preventable and that targeted interventions could contribute to improved child survival in the United States.
WILHELM HIS, JR. (1863-1934)
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Incorrect Data in a Table
Authors: Bronwyn Kingwell, Anuradha Aggarwal, Kellie D'orsa, Melissa Dmu, Anthony Formosa, Ravi Savarirayan, Anthony Dart
Journal: JAMA (2015)

1 We do not believe that management guidelines for Marfan syndrome have been changed as a result of this small clinical trial.While clinical governance procedures have been strengthened since publication of this study, the Institute has commenced a review with the purpose to further strengthen current audit practices and to minimize any possible risk of recurrence of such behavior.
Cardiac and Pulmonary Complications in Duchenne's Progressive Muscular Dystrophy
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
涉及毛发生长周期的一组基因的研究
Authors: N.J. Hawkshaw, J.A. Hardman, M. Alam, F. Jimenez, R. Paus
Journal: British Journal of Dermatology (2020)

个体毛发从毛囊中生长,经过一个包含不同阶段的周期。在“生长期”毛发生长旺盛,在“退化期”毛囊萎缩,而“休止期”是在下一个生长期之前毛发脱落的静止期。 毛发生长异常通常反映了毛发周期异常。例如,未能从休止期重新进入生长期,或者生长期持续时间短,导致毛发生长不良,而从休止期回到生长期的转变过度则会导致毛发过多。 如果我们能够了解如何控制这些阶段,则有可能开发出有效的治疗。 之前,科学家们已经成功在实验室中培养个体人生长期毛囊,但只能研究从生长期转变为退化期。这项最新研究的作者来自英国、西班牙、德国和美国,首次成功分离人休止期和早期生长期毛发。他们使用 5 名接受毛发移植的男性的头皮样本,并在显微镜下分离了相关毛发。 通过使用特异性抗体(体内的一种蛋白)来研究休止期毛囊,他们发现一组称为 WNT 通路的基因可通过促进毛芽(毛囊的一部分)中的某些细胞繁殖而诱发生长期。 通过研究可开始或关闭 WNT 过程的各种蛋白,他们能够大概了解在生长期开始时发生的事件,这将帮助未来科学家开发针对头发疾病的靶向治疗。 本摘要涉及研究:破译人毛发周期的分子形态:休止期到生长期转变过程中的 WNT 信号传导。
GENUINE DIPHTHERIA OF THE SKIN.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Indwelling Intravenous Polyethylene Catheters
Authors: Peter C. Fuchs
Journal: JAMA (1971)

To assess complications secondary to the use of indwelling intravenous polyethylene catheters, a study was conducted in which 500 catheter tips were cultured and results correlated with data obtained in each case. A catheter colonization rate of 3.8% occurred. The major factor influencing the frequency of catheter colonization is the presence of other catheter complications, such as subcutaneous infiltrations and phlebitis. The low colonization rate is attributed in part to the nature of this hospital and its patient population, and in part to the use of a team of specially trained "IV" nurses for insertion of most and maintenance care of all intravenous catheters. Frequent observation of catheters and their immediate removal at the first sign of patient distress or catheter malfunction are essential to successfully maintaining a lowered rate of colonization, infection, and septicemia.
Hematologic abnormalities in children with congenital heart disease
Authors: S. B. Kontras
Journal: JAMA (1966)

Hematologic studies were done on 145 children with congenital heart disease prior to open-heart surgery. Sixty-five of 111 patients with acyanotic-type disease showed some laboratory evidence of a preexisting hemorrhagic diathesis. Postoperative hemorrhage occurred in 40% of this group as opposed to 15% in the group with no demonstrable abnormality. Twenty-four of the 34 children with cyanotic congenital heart disease had abnormal blood studies and 10 of these had hemorrhage. Increased bleeding time with or without increased capillary fragility was most common in acyanotic types indicating either a microvascular abnormality or a qualitative platelet defect. Circulating fibrinolysin with decreased fibrinogen levels was seen in cyanotic tetralogy of Fallot. Twenty-two of 25 patients showed improvement in the hemorrhagic diathesis after definitive surgery.
The silent clap
Authors: A. E. Washington
Journal: JAMA (1981)

Asymptomatic gonorrhea, once considered the exclusive domain of women, is increasingly being recognized among men. Confirming earlier studies,<sup>1</sup>investigators in the 1970s have documented asymptomatic prevalence rates as high as 60% among infected men who are sexual partners of high-risk women,<sup>2-4</sup>ie, repeaters and women with gonococcal pelvic inflammatory disease (PID). Such reports highlight new opportunities for an improved strategy of control and for the physician's role in preventing cases. Potterat and King in this issue ofThe JOURNAL(p 578) argue that case interview resources should be redirected toward selected women, away from symptomatic men, with the intent of discovering more asymptomatic men. They attribute a reduction in gonorrhea incidence rates in their community to this new approach. The new approach began in El Paso County (Colorado) in late 1975. It is interesting to examine their comparative data for the period before their new program was initiated
A phase I, pharmacokinetic (PK) and pharmacodynamic (PD) study of the combination of an oral antimicrotubular agent, DJ-927 (D), and capecitabine (C) in patients (Pts) with advanced solid tumors
Authors: M. Beeram, M. W. Saif, J. Sarantopoulos, G. Schwartz, A. Patnaik, A. W. Tolcher, P. Cheverton, M. Kimura, M. Danna, C. H. Takimoto
Journal: Journal of Clinical Oncology (2005)

2037 Background: DJ-927 (D), an oral, microtubule stabilizer that causes growth arrest in a wide variety of human tumor cell lines, has impressive cytotoxic activity in taxane-sensitive, -resistant, and -refractory tumors and is associated with an acceptable incidence of hematologic toxicity. Taxane and Capecitabine (C) combinations are active in treating solid tumors such as breast cancer. Non-overlapping mechanisms of action and toxicity profiles and the convenience of an all orally administered combination therapy have prompted a phase I evaluation of the safety and tolerability of the combination. D was administered orally once on day 1 and C for 14-days (D1–14), every three weeks. Methods: Eligible pts had advanced, evaluable cancer, minimal prior therapy and performance status ≤ 2. Pts received D starting at 18 mg/m2 once on day 1and concurrent C 1,250 mg/m2 orally twice daily during wks 1 and 2, of a 3-weekly schedule. Incremental doses of both drugs are being explored until the maximum tolerated dose (MTD) is reached. Results: To date, 19 pts [12 Male/ 7 Female; median age (range)- 58 yrs (33–70); PS 0–2pts; PS 1- 17pts] have received 53 cycles of treatment [median (range)- 3 (1–6)] in 4 cohorts, with D and C 18/ 1250 mg/m2 (n = 3), 27/ 1250 mg/m2 (n = 7), 27/ 1900 mg/m2 (n = 6), and 27/ 2500 mg/m2 (n = 3). Dose-limiting toxicity (DLT) was observed in 1 of 6 pts at 27/ 1900 mg/m2 dose [grade (gr) 4 neutropenia & gr 4 thrombocytopenia]. Delayed toxicities observed include neutropenic fever (1), 2), gr 3 hand-foot syndrome (2) and gr 3 diarrhea (1). One pt with hepatocellular carcinoma had partial response at cycle 2 and 5 pts experienced disease stabilization lasting ≥ 16 weeks. Preliminary PK analysis suggests that C does not significantly alter the disposition of D. Conclusions: The combination of D and C appears safe and is well tolerated. Preliminary data suggest that this regimen may be active in pts with advanced cancers. Dose escalation continues at 35/ 1900 mg/m2 of D and C respectively. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Daiichi Medical Research Daiichi Medical Research