“Buffalo Humps” Associated with Protease Inhibitors
Authors: John T. Schindler
Journal: Annals of Internal Medicine (1999)

Letters2 February 1999“Buffalo Humps” Associated with Protease InhibitorsRaphael B. Stricker, MD and Billi Goldberg, MPARaphael B. Stricker, MDCalifornia Pacific Medical Center; San Francisco, CA 94120 (Stricker)International DNCB Study Group; San Francisco, CA 94114 (Goldberg)Search for more papers by this author and Billi Goldberg, MPACalifornia Pacific Medical Center; San Francisco, CA 94120 (Stricker)International DNCB Study Group; San Francisco, CA 94114 (Goldberg)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-130-3-199902020-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The letter by Schindler and colleagues (1) and recent articles by Lo (2) and Miller (3) and their coworkers describe cervicodorsal fat deposits (“buffalo humps”) and abdominal fat accumulation (“protease paunch”) in patients with HIV infection treated with protease inhibitors. The reports do not demonstrate a cause for the fat deposits, although Cushing disease was apparently excluded (1, 2).On the basis of these reports, there appears to be a spectrum of fat accumulation in HIV-infected patients receiving antiretroviral therapy. At one end of the spectrum is the “buffalo hump,” which Lo and colleagues found in some ...References1. Schindler JT, Spooner KM, Decker CF. “Buffalo humps” associated with protease inhibitors [Letter]. Ann Intern Med. 1998;129:164. LinkGoogle Scholar2. Lo JC, Mulligan K, Tai VW, Algren H, Schambelan M. “Buffalo hump” in men with HIV infection. Lancet. 1998;351:867-70. CrossrefMedlineGoogle Scholar3. Miller KD, Jones E, Yanovski JA, Shankar R, Feuerstein I, Falloon J. Visceral abdominal-fat accumulation associated with use of indinavir. Lancet. 1998;351:871-5. CrossrefMedlineGoogle Scholar4. Goldberg B, Stricker RB. HIV protease and the pathogenesis of AIDS. Res Virol. 1996;147:375-9. CrossrefMedlineGoogle Scholar5. Stricker RB, Goldberg B. Weight gain associated with protease inhibitor therapy in HIV-infected patients. Res Virol. 1998;149:123-6. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: California Pacific Medical Center; San Francisco, CA 94120 (Stricker)International DNCB Study Group; San Francisco, CA 94114 (Goldberg) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee Also“Buffalo Humps” Associated with Protease Inhibitors John T. Schindler , Katherine M. Spooner , and Catherine F. Decker “Buffalo Humps” Associated with Protease Inhibitors John T. Schindler , Katherine M. Spooner , and Catherine F. Decker Protease Inhibitors and Prohormone Processing Raphael B. Stricker and Billi Goldberg Metrics Cited ByProtease Inhibitors and Prohormone ProcessingRaphael B. Stricker, MD and Billi Goldberg, MPAOral Thrush and HIV Protease Inhibitors 2 February 1999Volume 130, Issue 3Page: 241-242KeywordsFatsHIVHormonesInsulin-like growth factorsNucleosidesProtease inhibitor therapyProtease inhibitorsProteasesViral loadWeight gain Issue Published: 2 February 1999 CopyrightCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...