tbuckley/cabot-search huggingface dataset:
Abstracts: Part IV
Authors: P Bovo, V Di, M Marcon, B Vaona, M Filippini, G Talamini, M Brunori, L Frulloni, M Leardini, E Dall'o', G Cavallini, E Niebergall-Roth, S Teyssen, M Hartel, D Wetzel, C Beglinger', M Singer, A Fung, G Tsiotos, M Sarr, G Rollandi, A Talenti, E Biscaldi, E Bonifacino, N Gandolfo, R Perrone, P Hammel, H Voitot, V Vilgrain, R Levy, J Fl6jou, P Ruszniewski, P Bemades, U Boggi, G Candio, P Giulianotti, F Sbrana
Journal: Gut (1996)

Gut 1996; 39 (Suppl3) very sensitive and specific identification in serum of the test substances in serum.We found good separation between healthy controls and patients with pancreatic insufficiency.Further studies of applicability and diagnostic efficiency are justified.
Shrinkers
Authors: George M. Sheehan
Journal: JAMA (1971)

<h3>To the Editor.—</h3> A year or two ago a query about the origin of the word "shrink" as applied to a psychiatrist failed to yield a definite answer from your consultant. I believe I may have found a possible original source in a poem entitled "Psychoanalysts," attributed to Christopher Morley: The old mandarin was always pleased When in his philosophical reading He encountered the names of Deep Thinkers. What an excellent name for a psychoanalyst Is Schrenk-Notzing For Truly They shrink from nothing.
Bird Fancier's Lung.
Journal: BMJ (1967)

PointersArrhythmias in Myocardial Infarction: Inci- dence and subsequent mortality found to be directly related to severity of the acute episode in a series of 200 cases monitored by Dr. E. Stock and colleagues from Melbourne (p.719).Leader at p. 715.Multiple Sclerosis in South Africa: In a 10- year survey of the white population Dr. Geoffrey Dean found higher prevalence in immigrant European stock than in local-born population (p.724).Progestogen for Contraception: Successful results without inhibition of ovulation in over 1,000 cases treated by Dr. J. Martinez- Manautou and colleagues from Mexico (p.730).Pregnancy in Adolescence: Increased incidence of pre-eclampsia in patients under 16 reported by Mr. B. V.
Effects of Massive X-Irradiation on Rat Electroencephalograms and Brain Serotonin
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Autonomic hyperreflexia in urologic surgery
Authors: R. M. Nieder
Journal: JAMA (1970)

Patients with cervical or high thoracic cord lesions frequently develop autonomic hyperreflexia during urologic procedures. The resulting severe hypertension may increase the danger of cerebral vascular accidents and cardiovascular derangement. Frequent monitoring of blood pressure is essential, and the hyperreflexia may be treated satisfactorily with ganglionic blocking agents. Sympatholytic agents have been ineffective. Prophylactic spinal or epidural anesthesia are alternative methods of abolishing this reflex.
Orthotopic liver transplantation for patients with hepatitis B virus-related liver disease
Authors: S Todo
Journal: Hepatology (1991)

Fifty-nine patients with prior hepatitis B virus infection underwent orthotopic liver transplantation.During the first 2 mo, mortality was not significantly different in the hepatitis B virus-infected group (25.5%) vs. a hepatitis B virus-immune control group (21 %).Beyond 2 mo, the mortality, rate of graft loss, need for retransplantation and incidence of abnormal liver function were significantly higher in the hepatitis B virus-infected group.Treatment of the hepatitis B virus infection was attempted with passive immunization, combined active and passive immunization, α-interferon or nothing.The clinical outcome was not significantly influenced by any of these therapies.However, of the patients who lived more than 60 days, 6 of 22 treated with active plus passive immunization were cleared of HBsAg, something achieved once in 16 patients treated with α-interferon, never in 3 patients with passive immunization only and once in 4 patients with no therapy.In patients with recurrent hepatitis B virus infection, the pace of hepatitis development in the graft appeared to be accelerated, and this was particularly striking in patients who underwent multiple retransplantations at progressively shorter intervals.None of the patients who became HBsAg-negative had HBeAg preoperatively.How to manage patients with HBV who undergo transplantation after developing end-stage chronic disease or fulminant hepatic failure (FHF) has been one of the unanswered questions in hepatology ever since it was realized that HBV can cause early or later graft loss (1,2).Liver replacement transiently lowers the viral titer in the blood, as determined by serial HBsAg testing (1-5).However, the virus is difficult to eradicate, almost ensuring that the viral infection will persist and that recurrent hepatitis will occur and impair the recovery and subsequent health of most recipients (3,4,6).Hepatitis B hyperimmune globulin (HEIG) (5-7), hepatitis B vaccine (HBVx) (5) and α-interferon (α-IFN) (8) have been administered alone or in some combination to such patients to prevent recurrent HBV infection in the new liver.The effectiveness of such therapies at clearing either the infection or the antigenemia is not established.This study reports observations on 59 adult patients who had chronic or fulminant HBV infection at the time of liver transplantation.Follow-ups are at least 19 mo.We have compared the courses of those 59 recipients with those of 38 other patients with postnecrotic cirrhosis (PNC) who were HBsAg negative but whose serum had anti-HBs, reflecting a previous HBV infection and presumed subsequent immunity.
Contempo 1997: family medicine
Authors: S. M. Solan
Journal: JAMA (1997)

<h3>In Reply.</h3> —We agree with Dr Solan that evidence for the efficacy of vitamin E in the prevention of coronary artery disease is less compelling than that for antiplatelet agents and estrogen in women. However, there is considerable evidence of benefit. Large prospective epidemiological cohort studies have shown strong associations between vitamin E use and decreased risk of cardiovascular events. Four populationbased studies involving more than 172 000 men and women show remarkable agreement, with high vitamin E intake being associated with a consistent reduction in risk of cardiovascular morbidity and mortality of between 36% and 58%.<sup>1-2</sup> Randomized controlled trials, primarily of secondary prevention, have yielded less impressive results. A large randomized controlled trial of large doses of natural (not synthetic) vitamin E in smokers and nonsmokers with proven coronary artery disease showed a risk reduction for nonfatal myocardial infarction and cardiovascular death of 47% in the vitamin E group, but
Computer Program Simplifies Record Keeping at Hospital
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Epidemic cutaneous herpes simplex in wrestlers (herpes gladiatorum)
Authors: C. E. Wheeler
Journal: JAMA (1965)

Infection of the skin with herpes simplex assumes a variety of forms which are classified as either primary or recurrent.<sup>1</sup>Primary infection is the initial infection, whereas recurrent disease represents activation of a herpetic focus which has lain dormant for weeks, months, or sometimes years. Cutaneous involvement in primary herpes simplex may accompany gingivostomatitis, keratoconjunctivitis, vulvovaginitis, balanitis, or urethritis.<sup>1</sup>In visceral herpes of the newborn, hepatitis of the malnourished, or herpetic meningoencephalitis, skin lesions are too inconspicuous and occur too infrequently to be of much diagnostic value.<sup>1-4</sup>Localized primary infections in which the skin is the portal of entry are probably most common on the hand, especially about the fingers, although they may occur anywhere. The so-called herpetic whitlow is a special hazard for dentists, nurses, and physicians who work about the mouths of persons who harbor the virus.<sup>5,6</sup>Primary Kaposi's varicelliform eruption is a generalized
Long-lasting behavioral changes following prednisone withdrawal
Authors: O. M. Wolkowitz
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diabetes Among Young American Indians—Montana and Wyoming, 2000-2002
Journal: JAMA (2004)

Type 2 diabetes is increasing among young American Indians (AIs) and other populations, and accurate surveillance is important to monitor trends in diabetes prevalence. The Indian Health Service (IHS) patient database has been used to identify cases of diabetes and estimate diabetes prevalence among AIs aged > or =15 years. However, limited studies have assessed the use of health databases to ascertain diabetes cases in young persons. The Montana Department of Public Health and Human Services (MDPHHS), in collaboration with the Billings Area IHS, conducted a study to assess use of the IHS patient database to identify AIs aged <20 years with diabetes in Montana and Wyoming. This report summarizes the results of that study, which found that diabetes cases were identified more accurately by using at least two patient visits for diabetes rather than only one patient visit. To reduce misclassification of diabetes, health-care systems and managed care organizations that use patient databases for diabetes surveillance should evaluate the accuracy of case ascertainment periodically and ensure adequate training for staff responsible for coding health-care visits and database entry.
The accuracy of diagnostic radiology. Arteriography and nephrotomography
Authors: J. Evans
Journal: JAMA (1968)

Cancer of the kidney frequently presents without overt signs or symptoms. Almost one third of such patients, in our experience, do not have signs or symptoms suggesting renal disease. Many patients with unsuspected renal neoplasms are discovered to have a renal mass during some nonurologic roentgenographic examination. Differentiation between renal cyst and neoplasm is usually not possible by conventional urographic means, except in those cases where there is characteristic deformity of the renal collecting system. In order to test the diagnostic vulnerability of conventional pyelography in the differentiation of renal cyst from neoplasm, we presented a series of 50 cases of undiagnosed renal masses to five experienced radiologists and found that a careful study allows correct diagnosis of either cyst or neoplasm in only 50% of cases. It is of further interest that in only 10% of the series was there agreement among the five observers in the diagnosis of
Abstract 3879: Inhibition of CXCR4 driven colorectal cancer progression by Nef-M1 peptide
Authors: Venkat R. Katkoori, Zeynoire Anderson, Upender Manne, Harvey Bumpers
Journal: Cancer Research (2019)

Abstract Introduction: The Nef-M1 peptide (Nef-M1) competes effectively with the natural ligand of CXCR4, SDF-1α, and exhibits anti-tumorigenic activity in human colorectal cancer (CRC). However, the molecular mechanisms of action of Nef-M1 on CRC remain unclear. In this study, we evaluated the inhibition of CXCR4 driven molecular signaling mechanisms that is involved in CRC progression. Experimental Design: Cell line derived xenografts (CDX), patient derived explant (PDE) and in vitro cell based models were used to examine the mechanisms of action of Nef-M1. The severe combined immunodeficient (SCID) mice with tumor were treated intraperitoneally with either Nef-M1 or scrambled amino acids sequence Nef-M1 (sNef-M1) that is the control. Preparation of CRC tissue, explant complete media, and cultures and treatment for 48 hours were performed for the PDE study. Sections from tumors were evaluated by immunostaining (IHC) for signaling proteins thus, implicating CRC progression. Western blot (WB) analyses were also performed on lysates of both cell lines and tumors to assess the effect of Nef-M1 on the signaling pathways that promote CRC progression. Results: The present study revealed that PDE recapitulate multiple biological features of the disease and these were found to be very similar to the corresponding original CRC. CXCR4 overexpressing CRC cells displayed activation of CXCR4/CREB signaling as demonstrated by an increased activation of CREB, and expression of B-Myb and APOBEC3B (A3B). IHC analysis for Ub-H2B, a stem cell signaling protein that correlates with advanced disease and metastasis indicated that Nef-M1 treated CDX or PDE tumors had low expression of Ub-H2B. However, sNef-M1 treated tumors had high expression of Ub-H2B. WB analyses indicated that Nef-M1 not only suppressed the expression of Ub-H2B, but also significantly suppressed the expression of A3B. Cells expressing CXCR4 became susceptible to Nef-M1-induced inhibition of Akt, mTOR activation and Ub-H2B expression. Conclusions: These results indicate that Nef-M1 suppresses CXCR4 driven activation of CXCR4/CREB signaling and the expression of Ub-H2B. Therefore, Nef-M1 inhibition of these signaling pathways may be a promising therapeutic strategy for CRC. This work was supported by NIH/NCI Workforce Diversity Grant R21-CA171251. Citation Format: Venkat R. Katkoori, Zeynoire Anderson, Upender Manne, Harvey Bumpers. Inhibition of CXCR4 driven colorectal cancer progression by Nef-M1 peptide [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3879.
The Eye in General Medicine: The Constitutional Factor in the Causation of Diseases with Special Reference to the Treatment of Diseases of the Eye.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Gabriela Tobias
Authors: C. Highton
Journal: BMJ (2009)

<h3>Abstract</h3> A large body of work suggests that biomolecular condensates ensuing from liquid-liquid phase separation mature into various material states. How this aging process is controlled and if the naive and mature phases can have differential functions is currently unknown. Using <i>Caenorhabditis elegans</i> as a model, we show that MEC-2 Stomatin undergoes a rigidity phase transition during maturation from fluid to viscoelastic, glass-like condensates that facilitate either transport or mechanotransduction. This switch is promoted by the SH3 domain of UNC-89/Titin/Obscurin through a direct interaction with MEC-2 and suggests a physiological role for a percolation transition in force transmission during body wall touch. Together, our data demonstrate a novel function for rigidity maturation during mechanotransduction and a previously unidentified role for Titin homologs in neurons.
P-276 Safety and Efficacy of mFOLFOX6 + Panitumumab Combination Therapy and 5-FU/LV + Panitumumab Combination Therapy in Patients with Chemotherapy-Naïve Metastatic Colorectal Cancer (SAPPHIRE)
Authors: N. Nagata, H. Mishima, S. Kurosawa, K. Oba, J. Sakamoto
Journal: Annals of Oncology (2016)
Reduction in types I and III collagen gene expression by an alphavbeta1 integrin inhibitor correlates with a decrease in PRO-C1 and PRO-C3 levels in precision-cut liver tissue slices from cirrhotic non-alcoholic steatohepatitis patients
Authors: Johanna Schaub, Steve Ho, Vikram Rao, Megan Marlow, Eric Lefebvre, Diana Leeming, Mette Juul Nielsen, Natasja Gudmann, Morten Karsdal, Scott Turner
Journal: Journal of Hepatology (2020)
Contents page + Editorial Board
Authors: Richard Masland, Tamara Glaser, Oliver Bru, John Mchaffie, Terrence Stanford, Barry Stein, Ve ´ronique Coizet, Peter Redgrave, Robert Stickgold, Matthew Walker, Andrew Singleton, Arin Bhattacharjee, Leonard Kaczmarek, Rui Costa, Camilla Drew, Alcino Silva, William Carlezon, Ronald Duman, Eric Nestler, Bazbek Davletov, Mark Bajohrs, Thomas Trendsin, Sian Lewis, Heather Yeomans, Patrick Liu, Manager Moulton
Journal: Trends in Neurosciences (2005)
EMANUEL SWEDENBORG (1688-1772) NATURAL SCIENTIST, NEUROPHYSIOLOGIST, THEOLOGIAN
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Error in Byline
Journal: JAMA Oncology (2015)

Sibylle Loibl, MD, PhD; André Schmidt, PhD; Oreste Gentilini, MD; Bella Kaufman, MD; Christine Kuhl, MD; Carsten Denkert, MD; Gunter von Minckwitz, MD; Anastasia Parokonnaya, MD; Hanne Stensheim, MD, PhD; Christoph Thomssen, MD; Kristel van Calsteren, MD, PhD; Philip Poortmans, MD, PhD; Paul Berveiller, MD; Udo R. Markert, MD; Frederic Amant, MD, PhD
Personalized Nanomedicine
Authors: Twan Lammers, Larissa Y. Rizzo, Gert Storm, Fabian Kiessling
Journal: Clinical Cancer Research (2012)

Personalized medicine aims to individualize chemotherapeutic interventions on the basis of ex vivo and in vivo information on patient- and disease-specific characteristics. By noninvasively visualizing how well image-guided nanomedicines-that is, submicrometer-sized drug delivery systems containing both drugs and imaging agents within a single formulation, and designed to more specifically deliver drug molecules to pathologic sites-accumulate at the target site, patients likely to respond to nanomedicine-based therapeutic interventions may be preselected. In addition, by longitudinally monitoring how well patients respond to nanomedicine-based therapeutic interventions, drug doses and treatment protocols can be individualized and optimized during follow-up. Furthermore, noninvasive imaging information on the accumulation of nanomedicine formulations in potentially endangered healthy tissues may be used to exclude patients from further treatment. Consequently, combining noninvasive imaging with tumor-targeted drug delivery seems to hold significant potential for personalizing nanomedicine-based chemotherapeutic interventions, to achieve delivery of the right drug to the right location in the right patient at the right time.