tbuckley/cabot-search huggingface dataset:
Notalgia Paresthetica
Authors: A. Bernard Pleet
Journal: JAMA (1979)

<h3>To the Editor.—</h3> Although unable to comment on hexing or root work as special forms of witchcraft, we would like to discuss the dysesthesia that occurred in the patient of Hillard and Rockwell (240:1742, 1978). Their patient experienced the gradual onset of numbness in the area of the inferior border of the left scapula, with intense burning sensation in this area in response to the lightest touch. On examination a 3×8-cm area of dysesthesia was present over the lower border of the left scapula. The authors do not state that this disappeared completely after the patient's extensive psychotherapy. Although conversion reaction or a hex may have been present in this patient, this particular dysesthesia was organic and is a well-known neurological entity. We have seen more than ten cases of this during the last two years and have recently reported six cases.<sup>1</sup>A sensory neuropathy involving the posterior rami
Points from Letters: Combined Loop and Pill
Authors: P. Last
Journal: BMJ (1970)

Coronavirus pandemic is the most important public health event in the world currently. Patients with coronavirus disease 2019 (COVID-19) in a critical state are at risk of progressing rapidly into many serve complications; they require a high level of care from ICU nurses. How to avoid the virus to infect health care worker is also a critical issue. Based on the summarized experience of Chinese health workers, literature review and clinical practice, this article introduced donning and doffing of personal protective equipment (PPE) protocol and some keypoints of nursing critical care in patients with coronavirus disease 2019 (COVID-19): caring of patients requiring intubation and ventilation, venous thromboembolism (VTE) prevention, caring of patients on ECMO, caring for patients requiring enteral nutrition, psychological support and nursing management of COVID-19 ICU. This article introduced a useful protocol of donning and doffing personal protective equipment to protect health care workers, and provided key points for the ICU nurses how to take care of COVID-19 patients.
Army Seeks Better Medical Evacuation Aircraft
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Factors with impact on the agreement between different readers in the interpretation of dobutamine stress echocardiograms Rainer Hoffmann, Don Poldermans, Harald Lethen, Paolo Fioretti, Peter van der Meer, Hans-Peter Tries, Rosanna Ciani, Alexander Katz, Raimun Erbel, Peter Hanrath, Thomas Marwick. University RWTH Aachen, Aachen, Germany
Journal: Journal of the American College of Cardiology (2001)
Equipping NK Cells with CARs
Journal: Cancer Discovery (2017)

Abstract Adding a chimeric antigen receptor (CAR) to natural killer (NK) cells is garnering interest as a therapeutic strategy because this immune cell type doesn't cause graft-versus-host disease, making its widespread, off-the-shelf use feasible. Based on promising preclinical data, a phase I/II trial of one such CAR NK-cell therapy is under way, targeting CD19 in hematologic malignancies.
Changes in bone metabolism after gastric cancer surgery: A prospective observational study.
Authors: Yosuke Atsumi, Yasushi Rino, Hiroo Wada, Yuichi Kitani, Yukihiro Ozawa, Toru Aoyama, Takashi Oshima, Norio Yukawa, Takaki Yoshikawa, Munetaka Masuda
Journal: Journal of Clinical Oncology (2018)

e16050 Background: Several retrospective studies have shown that bone disorders occur after gastric cancer surgery. This study was designed to prospectively evaluate the changes in bone metabolism after gastrectomy for gastric cancer. Methods: We prospectively enrolled 48 patients (66.9±9.5 yeas, 39 men and 9 women) with early gastric cancer who underwent gastrectomy. We employed dual energy X-ray absorptiometry (DEXA) to measure BMD. DEXA was performed before and 1 and 2 years after surgery to evaluate the BMD and T score of the lumbar spine. The serum levels of calcium (Ca), alkaline phosphatase (ALP), 1,25-dihydroxy vitamin D (1,25(OH)2VD), 25-hydroxy vitamin D (25(OH)VD), and estradiol (E2) were measured before surgery and every 3 months until 2 years after surgery. Results: DEXA revealed that the percent changes from the baseline BMD were -3.99% in the first postoperative year (P < 0.001) and -0.81% in the second postoperative year (P = 0.031). The rates of change in BMD did not differ significantly among the surgical procedures and the proportion of patients with a T score of ≤-1 at 12 months after gastrectomy was up to 54.2%. There was a strong significant correlation between the rate of change in the BMD and the rate of change in the serum Ca level 12 months after surgery; the correlation coefficient was -0.66 (P = 0.004). The serum ALP level significantly increased by 47.42±58.81 IU/L 9 months after surgery (P = 0.013). The serum 25(OH)VD level significantly decreased by 5.52±8.08 ng/ml 21 months after surgery (P < 0.001), whereas the serum 1,25(OH)2VD levels were consistently in the normal range. The serum E2 level significantly increased by 2.31±6.73 pg/ml 12 months after gastrectomy (P = 0.035). There was a significant inverse correlation between the rate of change in the BMD and the rate of change in the body weight 12 months after surgery; the correlation coefficient was -0.44 (P = 0.003). Conclusions: This study showed that the BMD of patients with gastric cancer significantly decreased within 12 months after gastrectomy regardless of the operative procedure. Our results suggested that even if body weight loss would be prevented, the BMD of patients could be considerably decreased after gastric cancer surgery.
MIND AND MATTER.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Disparity in Cancer Statistics Changing
Authors: M. Mitka
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Circulating glucose and insulin in surgery for insulomas
Authors: N. Schnelle
Journal: JAMA (1971)

Serial blood glucose and plasma immunoreactive insulin measurements during operations for insulomas were clinically useful in six patients. Mean blood glucose concentration rose by 40 mg/100 ml/hr during the initial 30 minutes after tumor removal, when no further functioning insuloma remained in situ. This information was available to the surgeon with a 15-minute delay. Insulin levels determined subsequently confirmed the assumptions based on glucose measurements. In addition to helping the surgeon to resect the least amount of pancreas necessary, these measurements enhanced the patient's safety from potentially dangerous hypoglycemia during anesthesia. Preoperative celiac arteriograms were done in five patients. They were helpful in localizing tumors in two patients and were retrospectively recognized to have correctly indicated the location of the tumor in a third patient.
Further Analysis Is Required to Identify an Early Stopping Rule for Peginterferon Therapy That Is Valid for All Hepatitis B e Antigen–Positive Patients. Δ
Authors: Milan J. Sonneveld, Vincent Rijckborst, Harry L.A. Janssen
Journal: Hepatology (2011)

We thank Piratvisuth and Marcellin for their valuable contribution to the debate. First of all, it is important to note that our findings of a more pronounced hepatitis B surface antigen (HBsAg) decline in hepatitis B e antigen (HBeAg)-positive patients with a response to peginterferon were confirmed in their study, reflecting the induction of an immune response in these patients.1 Their analysis shows that failure to achieve a decline in HBsAg levels through 12 weeks of therapy does not predict nonresponse as well in their cohort as it did in our study. Possible explanations for these discrepant findings could be the type of peginterferon or duration of therapy, as suggested by Piratvisuth and Marcellin. However, the most probable explanation is the difference in hepatitis B virus (HBV) genotype distribution between the study cohorts. Preliminary data from our group show that HBsAg decline among HBeAg-positive patients treated with peginterferon is strongly related to HBV genotype.2 These differences across genotypes, particularly among patients who fail to achieve a response, may be an important determinant of the performance of a threshold-based stopping rule. Consequently, the performance of any threshold is primarily dependent upon the distribution of HBV genotypes in the study cohort. The importance of HBV genotype when applying stopping rules for peginterferon therapy in chronic hepatitis B was recently illustrated by a validation study of our stopping rule for HBeAg-negative patients. This stopping rule, recommending discontinuation of peginterferon in patients who fail to achieve a decline in HBsAg and a decline in HBV DNA of >2 log at week 12, was based on a cohort of mostly genotype D patients.3 When validated in two independent study cohorts, performance was best in genotype D patients treated with either 48 or 96 weeks of peginterferon.4 In conclusion, monitoring of HBsAg levels during peginterferon therapy of chronic hepatitis B may provide valuable insight into a patient's probability of achieving a response. However, it appears that differences in HBsAg decline across HBV genotypes have to be taken into consideration. A pooled analysis of the data from our respective studies, stratified by HBV genotype and possibly incorporating HBV DNA levels, appears to be a crucial next step. Milan J. Sonneveld*, Vincent Rijckborst*, Harry L.A. Janssen*, * Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Abstract 2600: Interaction of host cell factor-1 with the oncoprotein transcription factor MYC
Authors: Tessa M. Popay, Lance R. Thomas, Jing Wang, Qi Liu, William P. Tansey
Journal: Cancer Research (2019)

Abstract Host cell factor (HCF)-1 is a highly-conserved epigenetic scaffolding protein that is essential for development, cell cycle progression, and cellular proliferation. Through integration into several chromatin modifying complexes, HCF-1 plays a critical role in regulating the activity of key transcription factors, such as the E2F family of proteins. HCF-1 is also linked to leukemogenesis, through its regulation by the BAP1 tumor suppressor and its incorporation into the oncogenic MLL complex. Despite its role in the cell cycle, presence at chromatin, and well-defined interactions, the function of HCF-1 in cancer remains under-studied and undetermined. Here we describe the role of HCF-1 in the context of its interaction with the transcription factor and oncoprotein MYC. MYC is overexpressed in most cancers and drives tumorigenesis by regulating the expression of genes involved in ribosome biogenesis, cell growth, and metabolism. The region of MYC responsible for interaction with HCF-1 is evolutionarily conserved in all vertebrate MYC family members, and we have previously demonstrated that mutations in MYC that selectively disable interaction with HCF-1 attenuate the tumorigenicity of MYC in vivo. This demonstrates that HCF-1 is an important co-factor for MYC-driven cancer. Using a battery of contemporary genomic approaches, including ChIP-seq, SLAM-seq, RNA-seq, and PRO-seq, coupled to a decisive CRISPR/Cas9 editing approach, we reveal the relationship of MYC and HCF-1 at chromatin and how this modulates the function of MYC as a transcription factor and oncoprotein. Citation Format: Tessa M. Popay, Lance R. Thomas, Jing Wang, Qi Liu, William P. Tansey. Interaction of host cell factor-1 with the oncoprotein transcription factor MYC [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2600.
Actors' Portrayals of Depression to Test Interrater Reliability in Clinical Trials
Authors: J. Rosen
Journal: American Journal of Psychiatry (2004)

OBJECTIVE: This study determined if actors could portray depressed patients to establish the interrater reliability of raters using the Hamilton Depression Rating Scale (HDRS). METHOD: Actors portrayed depressed patients using scripts derived from HDRS assessments obtained at three points during treatment. Four experienced raters blindly viewed videotapes of two patients and two actors. They guessed if each interviewee was a patient or an actor and rated the certainty of their guesses. For each interview, they also rated the realism of the portrayal and completed the HDRS. RESULTS: Experienced raters could not distinguish actors and patients better than chance and were equally certain of their right and wrong guesses. Actors and patients received high scores on the realism of their portrayals. The HDRS scores of the actor-patient pairs were correlated. CONCLUSIONS: Actors can effectively portray depressed patients. Future studies will determine if actors can accurately portray patients with anxiety and psychosis.
Effect of Laser Radiation On Tissues, Cells Discussed
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Spinal Puncture Needle
Journal: JAMA (1977)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Waiting
Authors: Rosemary D. Lombard
Journal: Annals of Internal Medicine (2013)

Ad LibitumSeptember 3, 2013WaitingRosemary D. LombardRosemary D. LombardFrom Hillsboro, Oregon.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-159-5-201309030-00015 Audio Reading - “Waiting” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Waiting," by R.D. Lombard. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail I. Letter From RadiologyAn “area of concern,” the letter said,and it seems a long time till morningwithout the distraction of day.I make a map to the clinic.I remember that sharp right turnthat wanders backwards after the bridge,and I wonder if life will spin a tight right on me,a different path from the one I had in mind.Another test tomorrow.II. First FrostEarly morning comes with stiffened blades of grass,their frosty tips still aimed to the summer meridian.They must wish too for an easier time.I'm thankful the ... Author, Article, and Disclosure InformationAffiliations: From Hillsboro, Oregon.Current Author Address: Rosemary D. Lombard; e-mail, [email protected]. PreviousarticleNextarticle Advertisement Audio Reading - “Waiting” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Waiting," by R.D. Lombard. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics September 3, 2013Volume 159, Issue 5Page: 368KeywordsBloodDiagnostic radiologyMammographyRiversUltrasound imaging ePublished: 3 September 2013 Issue Published: September 3, 2013 Copyright & PermissionsCopyright © 2013 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Kan–1 (Bile Acid Coa:Amino Acid N –Acyltransferase) Messenger Rna As A Novel Predictive Indicator for Prognosis of Hepatocellular Carcinoma Patients After Partial Hepatectomy
Authors: M Furutani, S Arii, H Higashitsuji, M Mise, M Niwano, T Harada, H Nakayama, M Fukumoto, M Imamura, J Fujita
Journal: Hepatology (1996)

We identified kan–1 complementary DNA (cDNA), the sequence of which is identical to bile acid CoA:amino acid N–acyltransferase (BAT), a liver enzyme that catalyzes the conjugation of bile acids with glycine or taurine. kan–1 (BAT) messenger RNA (mRNA) levels of the resected specimens obtained from 37 hepatocellular carcinoma (HCC) patients were studied in an attempt to evaluate prognostic significance in HCC patients after partial hepatectomy. Using Northern blot hybridization, kan–1 (BAT) mRNA levels were quantified in tumorous and nontumorous tissues, and the ratio of the former to the latter was defined as the kan–1 (BAT) ratio. Twelve patients had a kan–1 (BAT) ratio &lt; 0.5 (low kan– 1[BAT] ratio), and 25 patients had a ratio &gt;0.5 (high kan–1 [BAT] ratio). The patients with a low kan–1 (BAT) ratio demonstrated poorer survival than the patients with a high kan–1 (BAT) ratio ( P = .0013). The overall estimated hazard ratio for death in patients with a low kan–1(BAT) ratio was 68.05 according to a multivariate model ( P = .0005). Thus, the kan–1 (BAT) ratio may serve as a new molecular prognostic marker in HCC patients, following hepatic resection.
Pancreatic ERCP
Authors: R A Kozarek
Journal: Endoscopy (2006)

Like biliary endoscopy, pancreatic endoscopic retrograde pancreatography (ERCP) has evolved from being a diagnostic procedure to a therapeutic one. The advent of magnetic resonance cholangiopancreatography and endoscopic ultrasonography have limited the need for anatomic definition and transpapillary tissue sampling, respectively. This review is therefore limited to studies published during the past year concerned either with efforts to limit the incidence of post-ERCP pancreatitis or with critical reviews of therapeutic pancreatography, including the treatment of strictures, stones, and ductal disruption.