tbuckley/cabot-search huggingface dataset:
Research Highlights
Journal: Nature Immunology (2008)

Anti-inflammatory antibodiesIntravenous immunoglobulin is commonly administered to lessen inflammatory episodes in patients with autoimmune disease.In Science, Ravetch and colleagues elucidate the molecular structure of the carbohydrate moiety that confers anti-inflammatory properties onto the immunoglobulin G (IgG) molecules.N-linked 2,6-sialylated but not 2,3-sialylated Fc fragments protect mice from serum-induced autoantibody arthritis in the K/BxN mouse model.A recombinant IgG1 fragment glycosylated in vitro by sequential β1,4-galactosylation and 2,6-sialylation also confers protection against inflammation.Marginal zone macrophages show 'preferential' binding of the 2,6-sialylated Fc molecules.The authors hypothesize that these macrophages express a specific lectin receptor that binds these inhibitory IgG1 molecules to dampen inflammation.The identity of that putative lectin receptor remains unknown.
GLIMPSES OF THE PRACTICE OF MEDICINE AND SURGERY IN BRITISH AND SPANISH HONDURAS.
Authors: N. SENN
Journal: JAMA (1902)

<h3>SPANISH HONDURAS.</h3> Puerto Cortez, the principal seaport town on the Atlantic side of Spanish Honduras, is reached from Belize by boat in twelve hours. On the downward trip the steamers of the United Fruit Company make a short stop at Port Barrios. The larger part of the voyage is made in what is practically an inland sea made by the numerous islands, or keys, as they are called, situated some distance from the coast, constituting as they do a broken seawall. Port Barrios is a small dilapidated village notwithstanding it is the Atlantic terminus of the Guatemala Railroad. The cornerstone laid for a public building by the late General Barrios remains as he left it, but is beginning to show the effects of the ravages of the elements and the gradual decay of old age. Puerto Cortez is a strange little city, lining as it does the shore for more
Abstract 1758: Splicing component ISY1 interacts with APE1 and regulates base excision repair
Authors: Aruna Jaiswal, Elizabeth Williamson, Bhavita Patel, Gayathri Srinivasan, Kimi Kong, Carrie Lomelino, Satya Narayan, Robert Hromas
Journal: Cancer Research (2019)

Abstract Cellular genome is continuously challenged by endogenous and exogenous DNA damaging agents. In the genome, base modifications are the most common form of DNA damage. Base excision DNA repair (BER) is the most important pathway for the removal of oxidized or alkylated DNA. If these base modifications continue to persist, the replisome may stall at DNA lesions, causing the replication fork to collapse, leading to genetic instability. While the main components of the BER pathway are well defined, its regulatory mechanism remains poorly understood. We report here that apurinic/apyrimidinic endonuclease 1 (APE1), a multifunctional protein interacts with the pre-mRNA splicing factor ISY1. However, this interaction is independent of DNA or RNA based upon our pull-down experimental results. ISY1 expression is induced by oxidative or DNA alkylation damage, which would then provide an immediate up-regulation of APE1 activity in vivo and enhanced BER of oxidized bases. This was supported from our results of in vitro reconstituted experiment suggesting that ISY1 can stimulate 5’-3’ endonuclease 1 activity of APE1 in both the short- and long-patch BER pathways and increase its binding to AP site DNA. The interaction between ISY1 and APE1 also establishes a connection between DNA damage repair and pre-mRNA splicing. Based upon these results, we propose that ISY1 is an important regulator of BER and enhances the ability of APE1 to efficiently recognize abasic sites in DNA. Role of ISY1 becomes important in aging tissues where decreased APE1 activity results in the accumulation of oxidative genomic damages. Therefore, ISY1 may work as an anti-aging factor. Induction of ISY1 in malignancies could constitute a mechanism to avoid apoptotic death after treatment with alkylating agents. Citation Format: Aruna Jaiswal, Elizabeth Williamson, Bhavita Patel, Gayathri Srinivasan, Kimi Kong, Carrie Lomelino, Satya Narayan, Robert Hromas. Splicing component ISY1 interacts with APE1 and regulates base excision repair [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1758.
Association between vaginal douching and acute pelvic inflammatory disease
Authors: P. Wolner-Hanssen
Journal: JAMA (1990)

The vaginal douching habits of 100 consecutive municipal hospital patients with verified pelvic inflammatory disease (cases) were compared with those of 762 randomly selected controls (random controls) and 119 women thought to have pelvic inflammatory disease but in whom the diagnosis was not confirmed by laparoscopy and/or endometrial biopsy specimen (internal controls). Because patients had been symptomatic for no more than 3 weeks, current douching was arbitrarily defined as any douching during the previous 2 months. Current douching was more common among those with pelvic inflammatory disease than among random controls or internal controls. Among current douchers, pelvic inflammatory disease was significantly related to frequency of douching. For example, when cases were compared with random controls, those who douched three or more times per month were 3.6 times more likely than those who douched less than once per month to have confirmed pelvic inflammatory disease. A logistic regression model was used to adjust for demographic, behavioral, and other possible confounding variables. Even after adjustments, douching during the previous 2 months remained associated with pelvic inflammatory disease. These data suggest that among these women vaginal douching may be a risk factor for pelvic inflammatory disease. (<i>JAMA</i>. 1990;263:1936-1941)
Amputations for ischaemia.
Journal: BMJ (1969)

ArticlesMB~m 69 had a virus titre of 108.4 TCID5O (tissue culture infectious dose) and was free from all extraneous agents.In Kempe's first study 594 children, all of whom had eczema, were vaccinated either by multiple pressure or by the sub- cutaneous route with doses of virus from 30,000 to 1,000 TCID50.Compared with 36 normal children given com- mercially available smallpox vaccine, they showed less febrile reaction, and they had no complications. When 30,000
Corrigenda
Journal: BMJ (1936)

ANSWERSMTEDBICATTNL the same time for five minutes or so.Then the enamel dish is lifted off with a towel, emptied, drained, and shaken rapidly until quite dry and still sterile.Next the saucepan is taken off and the water drained off as rapidly and as completely as possible; with the aid of the instrument lifter practically all the, water can be drained off without the instruments falling out.As soon as possible the plunger should be fitted to the syringes, all water ejected, and the plunger worked up and down a few times to help the drying process.Then quickly the needles are fitted in turn and any moisture ejected-the plunger being well back, so that no moisture comes in on the back stroke.The plunger is then worked up and down a few times, so that hot air passes through needle.Enamel dish, needles, and syringes are still hot, of course, and my experience is that
TREASON AGAINST THE GOVERNMENT.
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medical News
Journal: JAMA (1980)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
New Antibiotic For Gonorrhea
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Phase II study: Induction chemotherapy and transoral surgery as definitive treatment (Tx) for locally advanced oropharyngeal squamous cell carcinoma (OPSCC)—An update and retrospective review of non-study patients.
Authors: Robert S. Siegel, Arjun Joshi, Reza Taheri, Nader Sadeghi, Punam Thakkar, Anonglack Vongpachith, Joseph Goodman
Journal: Journal of Clinical Oncology (2019)

6072 Background: The standard of care for OPSCC includes chemoradiation (CRT) or surgery with adjuvant radiation (RT). However, RT is associated with significant life long morbidity. We assessed the efficacy of a two-drug induction regimen, followed by transoral robotic assisted surgery (TORS) &amp; neck dissection for locally advanced OPSCC. Methods: This is an IRB approved single-arm phase II study for untreated stage III or IVA (AJCC 7 th edition) OPSCC patients (pts) with an ECOG &lt; 2 and GFR &gt; 50 cc. Induction cisplatin 75 mg/m2 and docetaxel 75 mg/m2 was administered every 21 days for 3 cycles. Patients then underwent TORS and neck dissection(s). At post-op visits, flexible laryngoscopy, blood tests, and imaging with PET/CT and/or MRI were done. Short and long term toxicity, progression-free survival, overall survival, and quality of life (QOL) were evaluated in all pts. Results: Twenty oropharyngeal pts were treated, 19 were male, 17 were Caucasian, and 19 were HPV+. Median age at dx was 57. Three pts were stage III, and 17 were stage IVA. Pathologic CR at the primary site occurred in 15 pts and CR among LN neck dissections occurred in 13 pts. Four pts were given dose-reduced chemo and 1 pt was changed to carboplatin per protocol because of renal dysfunction. Pre vs post tx QOL scores did not change. At a mean follow-up of 33 months (range 19.6 to 44.1), 18 pts are alive and NED. Three pts recurred a mean of 2.2 mos after surgery, and were treated with salvage CRT. Two pts died of metastatic disease, the third is alive and well. All 3 pts had positive LN (9 LN, 3 LN and 1 LN) at surgery. A fourth pt had 12 pos LN and received radiation. He has not recurred. A retrospective review of an additional 20 twenty pts treated in the same way, were also reviewed for efficacy. Mean age was 61.5. Two pts died of metastatic disease. Fourteen pts have been followed for &gt; 7 mos, and their mean overall survival is 44 mos. Conclusions: Cisplatin + docetaxel followed by TORS &amp; neck dissection(s) appears to be an effective model for the definitive treatment for OPSCC, while avoiding the adverse effects of RT.
Incorrect Reference.—
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Implementing the Report of the Citizens Commission on Graduate Medical Education
Authors: J. W. Haviland
Journal: JAMA (1969)

In late 1962 when the Board of Trustees of the American Medical Association asked the Citizens (Millis) Commission to study the problem of graduate education for physicians, it was in recognition of the need to make a broad and forwardlooking appraisal of the field with an eye to recommending apropriate and necessary changes. The extent of the proposed appraisal is best told by the following quotation from the specific charge to the commission, which was to make: (1) A determination of the various kinds of professional medical careers necessary to provide... society with medical services of a quality limited only by available knowledge. To the extent it is feasible, this would include an estimation of the quantitative distribution of the differing medical talents within the medical profession as a whole. (2) A definition of the general and specific characteristics of educational programs beyond medical school which will most effectively provide
Some current issues relating to rubella vaccine
Authors: S. R. Preblud
Journal: JAMA (1985)

At the time of licensure in 1969, available data indicated that rubella vaccines were safe, noncommunicable, and effective. Since vaccine virus could cross the placenta and infect the fetus, cautious use of the vaccines in childbearing-age women was recommended. Over the past 15 years, additional information about the vaccines has been accumulated. This article provides an update of data on (1) the risk and degree of joint symptoms following vaccination and revaccination, (2) the duration of vaccine-induced immunity, (3) the protective effect of low levels of vaccine-induced antibody, and (4) the risks to the fetus following maternal vaccination. The data support continued vaccination of all young children as well as increased efforts to vaccinate susceptible adolescents and young adults, especially women. Only by more effective vaccination of the latter can elimination of congenital rubella syndrome be hastened. (<i>JAMA</i>1985;254:253-256)
A phase I study of amrubicin (AMR) and irinotecan (CPT-11) in relapsed small cell lung cancer(SCLC)
Authors: M. Kawahara, A. Kubo, K. Komuta, M. Fukushima, T. Daimon, K. Furuse, T. Mio
Journal: Journal of Clinical Oncology (2008)

13548 Background: AMR and CPT-11 have shown excellent activity in extensive small cell lung cancer (SCLC). The aim of this study was to determine the maximum tolerated dose (MTD) of amrubicin in combination with a fixed dose of CPT-11. Methods: Eligibility criteria were patients having pathologically proven SCLC, had relapsed after one or two previous chemotherapies, ECOG performance status (PS) of 0–2 and adequate organ function. Irinotecan was delivered as 50 mg/m2 on days 1 and 8, every 21 days. AMR was delivered on day 1. Doses of AMR were level 1: 80mg/ m2, level 2: 90 mg/m2 and level 3: 100 mg/ m2. Dose elevation was determined using continuous reassessment method (CRM). Tolerability was assessed after the 1st cycle. Another two cycles were conducted when disease progression or unacceptable toxicities were not observed. Results: Between June 2004 and October 2006, 18 patients were enrolled with the following characteristics: male/female, 15/3; median age, 66.3 years (range 57–61); PS 0/1/2: 4/14/0. Median number of previous treatment cycles was 5. A total of 40 courses were conducted. Grade 3/4 hematological toxicities of 1st cycle were: leukocytopenia: 67% (G3/4: 8/4); neutropenia: 89% (G3/4: 6/10), thrombocytopenia: 11% (G3/4: 1/1). Grade 3 febrile neutropenia occurred in 1 patient. Other grade 3 or greater non-hematological toxicities were observed in 4 of 40 courses (grade 3 infection in 3 courses and diarrhea in 1). In the first course, DLT was observed in 2 of 6 patients at dose level 2 (prolonged grade 4 neutropenia, febrile neutropenia), in 1 of 6 at dose level 3 (prolonged grade 4 neutropenia), Both MTD and recommended dose of amrubicin determined by CRM were 100 mg/m2 (level 3). Objective response was obtained in 4 patients (29%). Median survival time was 1.1 year and 1-yr survival rate was 68%. Conclusions: This combination was well tolerated and showed encouraging activities in SCLC. Randomized phase II trials are being planned in chemo naïve SCLC. No significant financial relationships to disclose.
Enoxaparin pharmacokinetics and pharmacodynamics in obese subjects Ger-Jan Sanderink, Aim� Le Liboux, Navin Jariwala, Neasa Harding, Marie-Laure Ozoux, Umesh Shukla, Guy Montay, Bruno Boutouyrie, Adelaida Miro. Aventis Pharma, Antony, France, Novum Pharmaceutical Research Services, Pittsburgh, PA
Journal: Journal of the American College of Cardiology (2001)
Chemo-Electrical Transduction in Insect Olfactory Receptors
Authors: K-E Kaissling
Journal: Annual Review of Neuroscience (1986)

The brain's default mode network consists of discrete, bilateral and symmetrical cortical areas, in the medial and lateral parietal, medial prefrontal, and medial and lateral temporal cortices of the human, nonhuman primate, cat, and rodent brains. Its ...Read More
Preventing Falls in Assisted Living Facilities
Journal: Annals of Internal Medicine (2002)

Summaries for Patients21 May 2002Preventing Falls in Assisted Living FacilitiesSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-136-10-200205210-00003 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Falls are a major problem in frail older people who reside in assisted living facilities. They often result in serious injuries, such as hip fractures. Many factors predispose frail older people to falls, including unsteady gait and balance, weak muscles, poor vision, medications, and dementia (memory loss and confusion). External factors, such as poor lighting, loose rugs, poorly fitting shoes, clutter, and beds or toilets without handrails, also may cause falls. Preventing falls in frail older people requires many approaches to deal with the large number of predisposing ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Fall and Injury Prevention in Older People Living in Residential Care Facilities. A Cluster Randomized Trial.” It is in the 21 May 2002 issue of Annals of Internal Medicine (volume 136, pages 733-741). The authors are J Jensen, L Lundin-Olsson, L Nyberg, and Y Gustafson.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians–American Society of Internal Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoFall and Injury Prevention in Older People Living in Residential Care Facilities: A Cluster Randomized Trial Jane Jensen , Lillemor Lundin-Olsson , Lars Nyberg , and Yngve Gustafson Metrics 21 May 2002Volume 136, Issue 10Page: I-50KeywordsDementiaExerciseFallsHipHip fracturesMemoryMusclesRandomized trialsVisionWheelchairs ePublished: 21 May 2002 Issue Published: 21 May 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Loss of doctors from NHS remains stable
Journal: BMJ (1998)

Tobacco will kill a third of the young men in China China now consumes a third of the world's cigarettes, and on pp 1411 and 1423 Liu et al and Niu et al report large nationwide retrospective and prospective studies of the hazards of tobacco, with closely concordant results.The pattern of disease caused by smoking varies widely from one part of China to another, and between China and the West, but the overall risk is substantial and growing.In Britain and America about half of all persistent cigarette smokers are eventually killed by tobacco, and about the same overall risks will be seen in China.Two thirds of the young men become persistent smokers, so about 100 million of the 0.3 billion Chinese men now aged 0-29 will be killed by tobacco in middle or old age.