tbuckley/cabot-search huggingface dataset:
Tuberculosis
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Parallel 12: Hepatitis C: New Agents -Part 1
Journal: Hepatology (2014)

Hepatitis C is the commonest cause of hepatocellular cancer (HCC) in the US and the incidence is expected to increase further as the HCV population ages and develops more cirrhosis.Management of HCC is very heterogenous with multiple non-surgical and surgical options.The true cost of care of the HCV patient with HCC is unknown.AIMS: To evaluate the total direct health care costs of different approaches to HCC care in HCV patients in a major referral and transplant center.METH-ODS: 101 patients were randomly selected by computer from a list of all HCC patients with HCV between 2003 and 2013.All patients were biopsy-proven HCC or met UNOS OPTN criteria.Patients were categorized by the primary treatment modality of TACE, Cyberknife radiotherapy, radiofrequency abalation (RFA), chemotherapy or resection.Patients could have multiple treatment modalities and also go on to liver transplant, which is considered as a separate modality for cost determination.The direct cost includes the cost of the procedure, imaging, hospitalizations and all subsequent care of the HCC patient until either death or transplant including cost of HCV treatment and immunosuppression post-transplant.Costs were derived from the Medicare fee schedule abstracted from the HCUP NIS sample 2011.Medication costs used were wholesale acquisition costs (Redbook 2014).RESULTS: 101 patients, 82 male mean age 59years (range 49-82) were included.All had HCV cirrhosis at diagnosis with a median CTP score of 7 ( range 5-11) and a median MELD of 8. Genotype 1 (74%) and genotype 3 (16%) were predominant.31 patients were HCV treatment naïve, 65 treatment failures and 4 had had a prior SVR.Majority of HCC were detected through cross-sectional radiological screening programs.Liver staging using the Barcelona score was A1 20%; A2 18%; A3 16% and A4 27%; B 12% and C 7%.Tumor size was mean 2.8cms with a range from 1 -14cms.Mean follow up was 32 months with a range from 4 -118 and 37 patients have died.Initial primary treatment modalities were RFA 53%; TACE 26%; Cyberknife 10%, resection 8% and chemotherapy 2%.43 patients went on to liver transplantation.Calculated overall cost of HCC care for this group of patients was $22,030,108 for a mean cost per patient of $218,120.The 43 patients who underwent transplant accounted for $17,025,037 of the overall costs at $395,000 per transplanted patient compared to $5,817,300 for the non transplant patients for a mean cost of $100,299 per patient.CONCLUSIONS: Pharmaco-economic studies of HCV treatment need to model real life estimations of true direct cost of HCC care.
Enteral Stenting in 21 Patients with Malignant Gastroduodenal Obstruction
Authors: Tjun Tang, Mike Allison, Dunkley Irene, Phil Roberts, Richard Dickinson
Journal: Journal of the Royal Society of Medicine (2003)

Placement of an enteral stent is emerging as an effective alternative to surgery for symptomatic relief in patients with malignant gastric outflow and duodenal obstruction. We report experience in a series of patients who had the Wallstent enteral prosthesis inserted. 21 consecutive patients with inoperable obstruction, median age 75 years, had twenty-three procedures for insertion of the Wallstent under fluoroscopic guidance. Stent implantation was successful in 18 patients (86%), all of whom gained relief from nausea and vomiting. There were no short-term complications. Median survival after the procedure was four months (longest ten months), and no deaths were related to insertion. The efficacy and lack of complications in this series support use of the endoscopically placed stent for palliative management of malignant upper gastrointestinal obstruction.
P2.13-07 CUX1-ALK: A Novel ALK Rearrangement That Responds to Crizotinib in Non-Small-Cell Lung Cancer
Authors: M. Zhang, Q. Wang, Y. Ding, G. Wang, Y. Chu, X. He, X. Wu, Y.W. Shao, K. Lu
Journal: Journal of Thoracic Oncology (2018)
AUTHOR'S REPLY
Authors: C P Van Der Schans
Journal: Thorax (1992)

Body composition and exercise per- formance in patients with chronic ob- structive pulmonary disease (COPD)The original article ofDr A M W J Schols and others in the October issue of Thorax' shows that exercise performance, as indicated by the distance walked in 12 minutes, is related to the fat free mass of the patient.Fat free mass was taken to be an indicator of muscle mass, but the investigators found that arm muscle size was not well related to other measures of muscle mass.Several possible reasons for the relation- ship, two of which were related to respiratory muscle performance, were considered.There are, however, two other obvious possibilities.Firstly, muscle loss may well be from the lower limbs.If this were so, then exercise capacity could be reduced because of the smaller capacity for this type of exercise, irrespective of respiratory muscle function.Secondly, the patients who performed badly might take little regular exercise, or indeed may be limited by their symptoms in their exercise.Such patients would display lower limb muscle wasting.Consequently, performance may be related to muscle mass (particularly in the legs) by loss of activity.In the clinical evaluation of patients who are housebound with severe lung or cardiac dis- ease wasting of the quadriceps femoris and calf muscles is often a striking feature.Dr Schols and his colleagues suggest that a compromised nutritional state may con- tribute to impaired performance, and that muscle mass determines exercise performance.Unwary readers may be led to conclude that patients do badly because of malnutrition, or even that improved nutrition might be beneficial.This is not necessarily so.Correlation does not indicate cause and effect: even if there is such a relationship, which is cause and which is effect may not be self evident.
Grundriss der Mikrobiologie
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Remember nephrogenic diabetes insipidus in acute surgical patients taking lithium
Journal: BMJ (2001)

Helicobacter pylori testing is useful only in high risk patientsHelicobacter pylori testing in primary care is useful only in those at higher risk of developing peptic ulcer disease and is of no value in those at lower risk Three simple points from a patient's history-smoking, pain on an empty stomach, and history of peptic ulcer disease-can distinguish between those at high risk and those at low risk of peptic ulcer disease.In their cross sectional study of 565 primary care patients in the Netherlands, Weijnen and colleagues (p 71) found that these three variables had odds ratios of 5.5, 2.8, and 2.0 respectively.In those found to be at higher risk using this scoring rule, the predictive value for the presence of peptic ulcer disease increased from 16% to 26% after a positive Helicobacter pylori test.
Allergic reaction to transfused cephalothin antibody
Authors: D. R. Branch
Journal: JAMA (1979)

Antibodies to cephalothin sodium (Keflin) can be transferred passively via whole blood transfusion. In one case a mild allergic-type reaction was initiated in a patient who was receiving cephalothin therapy. This case is differentiated from a penicillin-caused allergic reaction. All patients that demonstrate allergic-type transfusion reactions should give drug histories. Investigation of passive transfer of antibodies to these drugs might be of benefit in any evaluation made. (<i>JAMA</i>241:495-496, 1979)
Les ferments des leucocytes en physiologie, pathologie et thérapeutique générales.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MNGI-38. LONG-TERM PROGNOSIS OF ATYPICAL AND MALIGNANT MENINGIOMA: OUTCOME AND PROGNOSTIC FACTORS
Authors: Sun-il Lee
Journal: Neuro-Oncology (2018)

AIMS: Twenty one atypical and fifteen malignant meningiomas were analyzed for long time to understand the long-term outcome and associated prognostic factors retrospectively. Thirty three (92%) meningiomas were macroscopically complete-resected in Simpson Grade I resection and three (8%) meningiomas were resected in Simpson Grade II. Ninety-one percent of all patients received whole brain radiotheraphy(WBRT) with nean dose of 52 Gy. We analyze the long-term survival, recurrence-free survival and prognostic significance of the grade of surgical resection and the difference between two groups. Recurrence free survival and median time to recurrence were significantly longer in atypical than malignant meningioma. But, the benefit of adjuvant radiotherapy was not effective significantly. Also the grade of surgical resection (Simpson Grade I vs II-III) were significantly related to prognostic survival. Pathological grade and the grade of surgical resection can be definite prognostic factors. However, multicenter prospective studies are necessary to clarify the management and the correct timing of radiotherapy in such a rare disease.
Effets des traitements de première intention de l’achalasie sur les résultats cliniques de la myotomie endoscopique (POEM)
Journal: Endoscopy (2019)

La POEM dans l’achalasie est une option thérapeutique après échec des traitements endoscopiques (injection de toxine botulique, dilatation pneumatique, prothèse oesophagienne) ou traitement chirurgical (myotomie de Heller). La question posée de cette étude est celle de l’influence d’un traitement antérieur de l’achalasie sur l’efficacité de la POEM. Pour répondre à cette question, cette équipe chinoise a analysé rétrospectivement tous les patients de leur centre ayant eu une POEM d’août 2010 à décembre 2014.
Brain Scans in Nonneoplastic Intracranial Lesions
Authors: Marvin C. Overton
Journal: JAMA (1965)

In the course of using chlormerodrin Hg 203 and chlormerodrin Hg 197 to detect and localize intracranial lesions, positive scans were obtained from numerous patients with nonneoplastic lesions. The diagnoses on these 66 patients have included cerebral infarction and contusion, intracerebral hematoma, aneurysms, arteriovenous malformations, brain abscesses, and subdural hematomas and abscess. Localization was possible in 70% of the patients, but cerebral angiography and at times air studies were necessary to determine the nature, severity, and surgical accessibility of the lesions. In some instances positive brain scans were indistinguishable from the scans associated with neoplasms encountered in patients with nonneoplastic lesions. We believe that it is imperative for the clinician to evaluate patients with positive scans carefully to determine the course of the abnormal concentration, rather than to assume that positive scans are evidence of neoplasms.
BOOK REVIEWS
Authors: P. A. VOLBERDING
Journal: JNCI Journal of the National Cancer Institute (1993)

Journal Article BOOK REVIEWS Get access AIDS: Etiology, Diagnosis, Treatment and Prevention, 3rd Edition , Vincent T. DeVita , Samuel Hellman , Steven A. Rosenberg , eds . Philadelphia : J. B. Lippincott , 1992 . 607 pp. $69.50. ISBN 0-397-51229-5 PAUL A. VOLBERDING, M.D. PAUL A. VOLBERDING, M.D. AIDS Program, Ward 84 San Francisco General Hospital995 Potrero Ave. San Francisco, CA 94110 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 85, Issue 1, 6 January 1993, Page 63, https://doi.org/10.1093/jnci/85.1.63 Published: 06 January 1993
Blue Madonna
Authors: Heather Treseler
Journal: JAMA (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ambulatory Electrocardiography
Authors: HAROLD L. KENNEDY
Journal: Annals of Internal Medicine (1979)

Letters and Correction1 January 1979Ambulatory ElectrocardiographyHAROLD L. KENNEDY, M.D.HAROLD L. KENNEDY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-1-124 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: A "natural history" follows the introduction of a new or innovative diagnostic technology as reported in the medical literature and may be described as follows: [1] initial reports exploring potential applications of the technology; [2] enthusiasts seeking and reporting advantages and usefulness of the new technology; [3] objective reports of the limitations or errors of such technology; and [4] correct clarification of the technology with regard to its indications, limitations, and adjunctive value for the practicing clinician. It seemed that the recent article by Crawford and associates (1) would contribute data to the third step of the...References1. CRAWFORD M, MENDOZA C, O'ROURKE R, WHITE D, BOUCHER C, and GORWIT J: Limitations of continuous ambulatory electrocardiogram monitoring for detecting coronary artery disease. Ann Intern Med 89:1-5, 1978 LinkGoogle Scholar2. FEINSTEIN A: Clinical biostatistics. XXXI. On the sensitivity, specificity, and discrimination of diagnostic tests. Clin Pharmacol Ther 17:104-116, 1975 CrossrefMedlineGoogle Scholar3. VECCHIO T: Predictive value of a single diagnostic test in unselected populations. N Engl J Med 274:1171-1173, 1966 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: HAROLD L. KENNEDY, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byComparison of ambulatory electrocardiography and exercise testing 1 January 1979Volume 90, Issue 1Page: 124-125KeywordsElectrocardiography ePublished: 1 December 2008 Issue Published: 1 January 1979 PDF downloadLoading ...
OP0049 A Genetic Variant in the Region of MMP-9 is Associated with Serum Levels and Progression of Joint Damage in Rheumatoid Arthritis
Authors: D. De Rooy, A. Zhernakova, R. Tsonaka, A. Willemze, F. Kurreeman, G. Trynka, L. van Toorn, R. Toes, T. Huizinga, J. Houwing-Duistermaat, P. Gregersen, A. van der Helm-van Mil
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> The severity of joint destruction is highly variable between Rheumatoid Arthritis (RA) patients. The majority of its heritability is still unexplained. Several auto-immune diseases share genetic risk variants that may also influence disease progression. <h3>Objectives</h3> We aimed to identify genetic risk factors for the severity of joint damage in RA by studying genetic susceptibility loci of several auto-immune diseases. <h3>Methods</h3> In phase-1, 3143 sets of X-rays of 646 Dutch RA-patients taken over 7-years (Sharp-van der Heijde (SHS) scored) were studied. Genotyping was done by Immunochip. Associations of SNPs with MAF &gt;0.01 and joint destruction were analyzed. In phase-2, 686 North-American RA-patients with 926 SHS-scored X-rays over 15 years of follow-up were evaluated. In both phases multiple testing corrections were done for the number of uncorrelated SNPs; the thresholds for significance were p&lt;1.1x10<sup>-6</sup> and p&lt;0.0036. MMP-9 levels were measured with ELISA in baseline serum samples. <h3>Results</h3> In phase-1, 109 SNPs associated significantly with joint destruction (p&lt;1.1x10<sup>-6</sup>). Of these, 76 were located in the HLA-region; the 33 non-HLA variants were studied in phase-2. Here two variants were associated with the severity of joint destruction: rs451066 on chromosome 14 (p=0.002, MAF=0.20) and rs11908352 on chromosome 20 (p=0.002, MAF=0.21). Rs11908352 is located near the gene encoding Matrix Metalloproteinase-9 (MMP-9). Serum levels of MMP-9 were significantly associated with the rs11908352 genotypes (p=0.007). <h3>Conclusions</h3> These data indicate that two loci that confer risk to other autoimmune diseases also affect the severity of joint destruction in RA. Rs11908352 may influence joint destruction via MMP-9 production. <h3>Acknowledgements</h3> This work has been supported by grants from the Dutch Arthritis Foundation (Reumafonds) and the Dutch organization of Health research and development (Zon-MW). The authors also would like to acknowledge the RACI study group. The Immunochip analyses were supported by BBMRI-NL. <h3>Disclosure of Interest</h3> None Declared
TINKERING WITH THE PURE-FOOD BILL.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Contents page + Editorial Board
Authors: Benjamin Leung, Scott Waddell, William Schwartz, Johanna Meijer, Matthew Benson, Roy Sillitoe, Derek Blake, Yoland Smith, Dinesh Raju, Jean-Francois Pare, Mamadou Sidibe, Sonia Garel, John Rubenstein, Brian Ackley, Yishi Jin, Evangelos Antzoulatos, John Byrne, Istvan Mody, Robert Trendsin, Sian Lewis, Heather Yeomans, Kate Burke, Manager Moulton
Journal: Trends in Neurosciences (2004)
David Sackett
Authors: R. Smith
Journal: BMJ (2015)

Recurrent miscarriage is frustrating for the physician and a heartbreaking experience for the patient. Approximately 5% of couples trying to conceive have two consecutive miscarriages. Despite a thorough study of patients, the aetiology of this common obstetric complication is unknown in 50% of cases. Known causes include abnormal chromosomes, endocrinological disorders and uterine abnormalities. Although antiphospholipid antibodies have been demonstrated in miscarriages, the role played by alloimmune mechanisms remains unclear. New immunological approaches such as natural killer cells, regulatory T cells, tumour necrosis factor α, cell-derived microparticles, leptin, certain glycoproteins and cytokines should be considered. The management of thyroid diseases and immunological disorders is continuously evolving. Several genetic diagnostic procedures such as parental karyotyping and preimplantation genetic screening should probably not be used routinely. Antiphopholipid syndrome and some recurrent miscarriage-related endocrinological disorders can be effectively treated. Finally, new therapeutic approaches and the pleiotropic effects of old ones have led to improved fetal–maternal outcomes.