tbuckley/cabot-search huggingface dataset:
The Pseudolymphogram
Authors: Gene P. Wegner
Journal: JAMA (1967)

Large bowel carcinoma metastatic to periaortic lymph nodes mimicked roentgenographically the appearance of retained contrast medium following lymphography in two cases. Lymphography in both patients, however, demonstrated complete metastatic tumor replacement of these nodes, with calcification. Of 368 consecutive patients with proved large bowel adenocarcinoma, six or 1.6% showed periaortic nodal calcification. We reviewed various opinions regarding the stimulus to calcification in intestinal neoplasms.
Acute and chronic vessel responses to direct stenting vs stenting with predilatation: A serial intravascular ultrasound study Shinichi Shimodozono, Yasuhiro Honda, Ronald P. Caputo, Charles D. O'Shaughnessy, Reginald L. Low, Barry D. Rutherford, Patrik C. Zetterlund, Campbell D. K. Rogers, Paul G. Yock, Donald S. Baim, Peter J. Fitzgerald. Stanford University, Stanford, CA, Brigham and Women's Hospital and Harvard Medical School, Boston, MA
Journal: Journal of the American College of Cardiology (2001)
THE HEATED TERM.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
GP intervention cuts risk factors in patients with type 2 diabetes
Journal: BMJ (2001)

Secondary prevention programmes in coronary heart disease improve care Specialised multidisciplinary clinics for patients with coronary heart disease improve patient care and quality of life or functional status.McAlister and colleagues reviewed 12 randomised controlled trials including nearly 10 000 patients and found greater prescription of efficacious drugs and better risk factor profiles in patients assigned to specialised clinics rather than usual care (p 957).Admissions to hospital were also reduced.The optimal mix of components and the cost effectiveness of the clinics remain unclear.
P1-01-12: Mesoporous Silicon Particles for the Presentation of Tumor Antigens and Adjuvant for Anti-Cancer Immunity.
Authors: IM Meraz, B Melendez, J Gu, RE Serda
Journal: Cancer Research (2011)

Abstract Custom-made vaccines based on personalized tumor antigens are realistic options for secondary therapy, with the patient's excised tumor providing antigens. Overlap in the personalized repertoire of tumor antigens among patients also provides insight into targets for preventative cancer vaccines. Nanotechnology provides carriers for shielded delivery of antigens and presentation of immunostimulatory molecules. Rapid uptake of particles by phagocytic immune cells and migration to lymphatic tissue for antigen presentation provides opportunities to elicit tumor specific immune responses. Dendritic cells (DC) are the master antigen presenting cells (APC) for efficient processing and presentation of antigens. We have tested the ability of mesoporous silicon particles (pSi) to function as substrates for DC and to activate cells via engagement of surface toll-like receptors (TLR). pSi particles, surface labeled with lipopolysaccharide (LPS) or monophosphoryl lipid (MPL), were presented to bone marrow-derived DC. This resulted in rapid uptake of particles, with an enormous capacity for number of particles internalized per cell. Confocal microscopy studies supported higher uptake of LPS and MPL conjugated as compared to unlabeled pSi. pSi particle uptake into DC was also supported by electron microscopy imaging. TLR ligands induced morphological changes in GM-CSF stimulated cells consistent with maturation towards a DC phenotype. As expected, LPS conjugation to particles resulted in significant toxicity. MPL conjugated pSi showed little or no toxicity to DC and showed improved particle uptake into DC with morphological changes consistent with maturation towards a mature DC phenotype.The impact of cytokine cocktail on DC maturation and its impact on particle uptake were also examined. Flow cytometry analysis supported greater uptake of pSi by DC stimulated with GM-CSF and IL-4 compared to GM-CSF alone, with reduced uptake in the presence of TNF-alpha. Consistent with findings reported by others, addition of TNF-alpha to the cell media also resulted in higher levels of expression of costimulatory molecules by DC, compared to cells stimulated with GM-CSF alone. Thus immature DC are better able to internalize particle-based vaccines, with cytokine or TLR-driven maturation enhancing expression of costimulatory molecules for more effective antigen presentation. Citation Information: Cancer Res 2011;71(24 Suppl):Abstract nr P1-01-12.
Die Haut- und Geschlechtskrankheiten: Eine zusammenfassende Darstellung für die Praxis
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 3237: Combinatorial immune checkpoint inhibitor therapy in anaplastic thyroid cancer
Authors: Sanjukta Chakraborty, Rachana R. Maniyar, Sina Dadafarin, Ghada Ben Rahoma, Sarnath Singh, Augustine Moscatello, Jan Geliebter, Raj K. Tiwari
Journal: Cancer Research (2019)

Abstract Anaplastic thyroid cancer(ATC) is a rare but extremely aggressive form of endocrine malignancy that accounts for only 1-2% of total thyroid cancer cases but responsible for 20-30% of annual mortality from thyroid cancer in the USA. Genetic lesion landscape in ATC is not conducive to multiple targeted therapies. BRAF mutation is one of the dominant genetic lesions observed in 30-40% of ATC cases and 98% of them are BRAFV600E positive. Due to the limited therapeutic efficacy of BRAFV600E inhibitor vemurafenib, identification of novel therapeutic candidates would provide a viable alternative. Immunecheckpoint therapies have showed huge promise in recent years but are relatively underexplored in ATC patients. To this end, 4 ATC cell lines 8505C, T238, SW1736 and HTh74; 3 PTC cell lines TPC-1, BCPAP and K1 and 1 FTC cell line CGTH-W-1 were screened for expression of 29 immune-checkpoint molecules by qRT PCR with or without 10μM vemurafenib treatment for 24 hrs. Initial screening revealed a differential expression level of the transcripts among the cells. Vemurafenib treatment further up regulated expression of CD160, HVEM, BTLA, TIM3 and galectin9 in cell lines positive for BRAFV600E mutation (8505C, SW1736, BCPAP) and the ones harboring an additional PIK3CA mutation (T238, K1). This observation was further confirmed by immunocytochemistry. CD160 was not detected in any of the cell lines except for K1, TPC-1 and NTHY at protein level. Flow cytometry confirmed presence of BTLA, HVEM and TIM3 on the surface of these tumor cells which would enable them to engage their cognate ligands on T cells and suppress antitumor immune response. Western blots confirmed upregulation of BTLA, HVEM, TIM3 and galectin 9 in response to vemurafenib in both BRAFV600E positive cell lines and HTh74. Expression of these molecules were also validated by immunohistochemistry in patient samples. In an effort to evaluate the functional activity of these immunecheckpoint molecules, co-culture studies were done. Both HVEM and BTLA showed immunomodulatory capability and were capable of redirecting T cell differentiation towards a suppressive phenotype. Preclinical studies with combination of BRAFV600E or PI3K inhibitor and antagonistic antibodies against these molecules are currently underway. This study has identified two novel immune checkpoint molecules in ATC and might provide viable therapeutic targets. Citation Format: Sanjukta Chakraborty, Rachana R. Maniyar, Sina Dadafarin, Ghada Ben Rahoma, Sarnath Singh, Augustine Moscatello, Jan Geliebter, Raj K. Tiwari. Combinatorial immune checkpoint inhibitor therapy in anaplastic thyroid cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3237.
NTP Announces Bioassay Results
Journal: Environmental Health Perspectives (1994)

asked his staff to analyze the gaps in the availability of environmental health sci- ences information to the public and devel- oping a plan for implementing the clear- inghouse."The excellent science done at NIEHS is at the heart of our mission, but unless information from our laboratories and our scientists is accessible to a wider public, NIEHS cannot fulfill its mission," Olden said."The clearinghouse will reach out to environmental journalists, environ- mental justice organizations, educators, and other target audiences.The public's requests for information and public comments received by the clearinghouse will better enable the institute to respond to the needs of the American people."When appropriate, the clearinghouse will provide written material describing NIEHS research and training programs, and callers will be referred to other clearinghouses, toll-free numbers, federal, state, and local agencies, and information sources as needed.Full use will be made of various computer networks and the developing information superhighway to make information readily available to the public.The Office of Planning and Commun- ications at the NIEHS has worked closely with Information Ventures, Inc., a Philadelphia-based contractor, to bring the Clearinghouse on-line.Daniel VanderMeer, director of the NIEHS Office of Planning and Commun- ications, has been the NIEHS project officer for the clearinghouse since the beginning planning stages."The clearinghouse is designed to
THE YELLOW FEVER GERM.
Journal: JAMA (1889)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE MILLING PROCESS AND BERIBERI IN WAR TIME
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dull in tooth and mind.
Journal: BMJ (1971)

first suggested."1Furthermore, a thoracic duct fistula is difficult to keep draining for more than a few days, and once it becomes occluded bleeding is likely to recur.In summary the control of oesophageal haemorrhage remains an unsolved problem, while the prognosis is deter- mined largely by the patient's liver function.The desirability, timing, and nature of any of the possible surgical procedures are still not established.
COUNCIL ON PHARMACY AND CHEMISTRY.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
P66.04 A Multimodal Biomarker Predicts Dissemination of Bronchial Carcinoid
Authors: E. Reuling, D. Naves, E. Thunnissen, P. Kortman, M. Broeckaert, P. Plaisier, C. Dickhoff, J. Daniels, T. Radonic
Journal: Journal of Thoracic Oncology (2021)
Cytomegalovirus retinitis and low‐grade non‐Hodgkin's lymphoma: Case report and review of the literature
Authors: L.A. Derzko‐Dzulynsky, A.R. Berger, N.L. Berinstein
Journal: American Journal of Hematology (1998)

Patients with non-Hodgkin's lymphoma may develop retinal or choroidal lesions during the course of their disease. New immunosuppressive therapies currently used in reticuloendothelial malignancies have increased the incidence of opportunistic infections in this patient population. The differentiation of lymphomatous infiltration from opportunistic infection as a cause of chorioretinal infiltrates is critical, as the treatments are fundamentally different. We report a case of a patient with non-Hodgkin's lymphoma who developed a chorioretinal infiltrate that was initially thought to represent progressive disease. The patient received radiation treatment appropriate for intraocular lymphoma. The lesion progressed further and after reevaluation a diagnosis of cytomegalovirus retinitis was made and therapy initiated. Review of the literature for intraocular lymphoma and cytomegalovirus retinitis is provided and diagnostic strategies are described. We recommend analysis of intraocular fluid when there is difficulty in clinically differentiating intraocular lymphoma from opportunistic infection. Am. J. Hematol. 57:228–232, 1998. © 1998 Wiley-Liss, Inc.
Authors' response
Authors: S. Ewig, N. Birkner
Journal: Thorax (2010)

We welcome the letter from Dr Iles and the opportunity to make additional comments on the subject of our recent editorial. 1 It is correct that the mortality rate in normotensive patients with acute pulmonary embolus (PE) reported in the recent study by Boca et al 2 refers to all-cause mortality at 3 months and not inpatient mortality, and we are pleased to have the opportunity to clarify this.A wide range of mortality rates in acute PE have been reported in published studies, depending on whether hypotensive and normotensive patients are included together or reported separately and whether inpatient, 30-day or 3-month mortality is quoted as an end point.Furthermore, identifying the exact cause of death in studies of PE is very difficult and few if any have been able to provide accurate data on this, therefore most report all-cause mortality.In the recent European Society of Cardiology guidelines on acute PE 3 it states that the risk of early mortality in normotensive patients with acute PE is dependent on the presence of right ventricular dysfunction (RVD) on transthoracic echocardiography, with studies reporting rates of 3e15% in those who are normotensive with RVD and <3% in those without RVD.Indeed, in the ICOPER study, 4 50% of normotensive patients with acute PE had RVD and the mortality in that group was 10%, much higher than in those who were normotensive but without evidence of RVD.These observations imply that, even in normotensive patients, clot burden as implied by the presence of RVD contributes to the risk of early death.This suggests that death after PE in those normotensive at presentation is not simply down to other diagnoses such as cancer but that cardiorespiratory comorbidities are likely to contribute to the risk in an additive way.In a recent study by Ibrahim and colleagues which included >15 000 patients with acute PE, the 30-day mortality rate in normotensive patients not receiving thrombolysis was 7.7% and the in-hospital mortality rate for normotensive patients who did not receive thrombolysis was 7.2 per 1000 person days. 5We therefore believe that it would be wrong to underestimate the early acute PE-associated mortality risk, even in normotensive patients.We believe this is significant in those with objective evidence on echocardiography or on cardiac biomarkers of RVD.It is this association which is eloquently described in the original article on which our editorial was based, stressing its importance to the literature.
DISCUSSION ON HYPNOTISM.
Journal: JAMA (1890)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Radiography of the Chest. Vol. 1. Pulmonary Tuberculosis.
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
STATE MEDICINE.
Journal: JAMA (1890)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal