tbuckley/cabot-search huggingface dataset:
STATISTICS IN MEDICINE
Authors: PAUL E. LEAVERTON
Journal: Annals of Internal Medicine (1969)

Letters and Comments1 April 1969STATISTICS IN MEDICINEPAUL E. LEAVERTON, PH.D.PAUL E. LEAVERTON, PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-70-4-869_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: It seems apparent that Dr. Feinstein's article, "Clinical Epidemiology III: The Clinical Design of Statistics in Therapy" (Ann. Intern. Med. 69: 1287, 1968) was not reviewed by a biostatistician. Being an "average biostatistician" and since much of the discussion dealt with statistics in medical research, I feel compelled to comment on some of the misrepresentations.1. It is not true that for "statistical evaluation" a group of patients may be regarded as homogeneous only if they are all equally likely, before treatment, to achieve the condition that is the object of therapy. It is true that inattention...Reference1. COX CP: Some observations on the teaching of statistical consulting. Biometrics 24: 789, 1968. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: PAUL E. LEAVERTON, PH.D.Affiliations: Department of Statistics Department of Preventive Medicine & Environmental Health College of Medicine The University of Iowa Iowa City, Iowa PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1969Volume 70, Issue 4 Page: 869-870 Keywords Clinical epidemiology ePublished: 1 December 2008 Issue Published: 1 April 1969 PDF downloadLoading ...
The Lead Treatment of Cancer
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Protective effect ofS-adenosyl-L-methionine on bromobenzene- andD- galactosamine-induced toxicity to isolated rat hepatocytes
Authors: J Wu, H Soderbergh, K Karlsson, Å Danielsson
Journal: Hepatology (1996)

The protective effect of S -adenosyl-l-methionine (SAMe) on bromobenzene (BB)- or d-galactosamine (GalN)-induced damage to isolated rat hepatocytes and its effect on cellular glutathione (GSH) levels were investigated. SAMe at concentrations of 0.5 to 3.0 mmol/L significantly reduced lactate dehydrogenase leakage from cells exposed to 1.6 mmol/L BB ( P &lt; .05 to .001) during 2 hours’ incubation. GalN at 25 to 50 mmol/L induced a marked increase of LDH leakage from the cells during the later stage of 24 hours’ incubation and SAMe at 1.0 mmol/L clearly attenuated the LDH leakage in GalN (25 mmol/L)-exposed cells. The GSH content in the cells exposed to 2.4 mmol/L BB for 150 minutes was markedly decreased, and further decreased during 24 hours’ incubation. SAMe (1.5 mmol/L) both reduced LDH leakage and corrected GSH depletion in cells exposed to 2.4 mmol/L BB. The GSH content in 25 and 50 mmol/L GalN-exposed cells was strikingly diminished to 51.2% and 32.8% of the controls, respectively, during 24 hours’ of exposure. SAMe at 1.5 mmol/L significantly reduced the loss in GSH content in 25 mmol/L GalN-exposed cells. The findings show that SAMe has beneficial effects on both BB- and GalN-induced toxicity to rat hepatocytes. The main mechanism behind the protective effect of SAMe on BB and GalN toxicity seems to be associated with enhancement of GSH synthesis in the cells.
Correction: <i>Two roads for oncolytic immunotherapy development</i>
Authors: Michael Timaner, Ziv Raviv, Shai Shen-Orr, Yuval Shaked, Tongwu Zhang, Ksenia Magidey-Klein, Tim J Cooper, Ksenya Kveler, Rachelly Normand, Brian P. James, Roi Gazit, Ze'ev A. Ronai
Journal: Journal for ImmunoTherapy of Cancer (2021)

This correction notice is to note that second sentence of the first paragraph should be corrected from 'Globally, there are three approved oncolytic viruses, an adenovirus (H101) for the treatment of advanced head and neck cancer in China, Rigvir, an oncolytic reovirus approved for the treatment of advanced melanoma in Estonia, Latvia, Poland and Belarus, and most notably, talimogene laherparepvec (T-VEC), an oncolytic herpes simplex virus, type 1 (HSV-1) approved for the treatment of advanced melanoma in the United States, Europe and Australia. 1 2 To 'Globally, there are three approved oncolytic viruses, an adenovirus (H101) for the treatment of advanced head and neck cancer in the People's Republic of China; Rigvir, an oncolytic echovirus approved for the treatment of advanced melanoma in some Eastern European countries; and most notably, talimogene laherparepvec (T-VEC), an oncolytic herpes simplex virus, type 1 (HSV-1) approved for the treatment of advanced melanoma in the United States, Europe, Australia and Israel.' 1
Eight hours? inhalation of prostacyclin (PGI2) in healthy lambs: effects on tracheal, bronchial, and alveolar morphology
Authors: O. Habler, M. Kleen, S. Takenaka, R. Leiderer, R. Pusch, M. Welte, B. Zwissler, K. Messmer
Journal: Intensive Care Medicine (1996)
Medical Diagnosis: Present, Past, and Future
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Targeting PYK2 Mediates Microenvironment-Specific Myeloma Cell Death
Authors: Mark B Meads, Bin Fang, Linda Mathews, Jennifer Gemmer, Liang Nong, Ismael Rosado-Lopez, Tuan Nguyen, Jennifer E. Ring, William Matsui, Robert MacLeod, David T. Weaver, Jonathan A. Pachter, Lori A. Hazlehurst, John M. Koomen, Kenneth H. Shain
Journal: Blood (2015)
Response Assessment of 223Ra Treatment: Should a Fluorocholine PET/CT Be Performed?: Reply
Authors: Ana María García Vicente, Angel Soriano Castrejón
Journal: Clinical Nuclear Medicine (2018)

Nuclear Medicine Department Hospital General Universitario de Ciudad Real Ciudad Real, Spain [email protected] All the authors have participated in the writing and revision of this article and take public responsibility for its content. The present publication is approved by all authors and by the responsible authorities where the work was carried out. All the authors confirm the fact that the article is not under consideration for publication elsewhere.
BOOK REVIEWS
Authors: D. L. MCCARLEY
Journal: JNCI Journal of the National Cancer Institute (1990)

Journal Article BOOK REVIEWS Get access Therapeutic Progress in Urological Cancers: Progress in Clinical and Biological Research, Volume 303. Gerald P. Murphy , Saad Khoury , eds. New York : Alan R. Liss, Inc. , 1989 , 913 pp. $180. DEAN L. MCCARLEY DEAN L. MCCARLEY Division of Medical Oncology University of Florida College of Medicine and Gainesville Veterans Administration Medical CenterGainesville, FL 32602 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 82, Issue 3, 7 February 1990, Pages 229–230, https://doi.org/10.1093/jnci/82.3.229 Published: 07 February 1990
Colonic Irrigation.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Virus of Poliomyelitis in Stools and Sewage
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Expert consensus on standardized diagnosis and treatment for heat stroke
Journal: Military Medical Research (2016)

Heat stroke is a life-threatening disease characterized clinically by central nervous system dysfunction and severe hyperthermia (core temperature rises to higher than 40 °C). The unchecked rise of body core temperature overwhelms intrinsic or extrinsic heat generation mechanism, thus overwhelms homoeostatic thermoregulation. Hyperthermia causes cellular and organ dysfunction with progressive exacerbation resulting in multi-organ failure and death. Rapid cooling to reduce core temperatureas quickly as possible is the primary and most effective treatment, as it has been shown that the major determinant of outcome in heatstroke is the degree and duration of hyperthermia. If suppression of body temperature is delayed, the fatality rate will be elevated. This is a guideline for the management of heat stroke, developed by the People's Liberation Army Professional Committee of Critical Care Medicine lauched in June 2006. This is the first and origianl guideline for heat stroke in Chinese army and is expected to be properly used in daily clinial practice.
Concurrent Lymph Node Metastases of Medullary and Papillary Thyroid Carcinoma in a Case with RET Oncogene Germline Mutation
Authors: G. Papi, S. Corrado, M. G. Pomponi, C. Carapezzi, A. Cesinaro, V. A. LiVolsi
Journal: Endocrine Pathology (2003)
MEDICAL EDUCATIONAL STATISTICS.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Surgery
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Risk factors for cutaneous melanoma. A practical method of recognizing predisposed individuals
Authors: A. R. Rhodes
Journal: JAMA (1987)

Cutaneous melanoma is rapidly becoming a potentially curable cancer if it is detected and properly treated in an early phase of development. Unlike other cancers, which are usually hidden from detection until they are relatively large or metastatic disease has occurred, cutaneous melanoma is readily detectable simply by examining the skin. Information is now available that will be useful in selecting individuals at greatest risk. The most important melanoma risk factors (in decreasing order of importance) for a given individual are as follows: a persistently changed or changing mole, adulthood, irregular varieties of pigmented lesions (including dysplastic moles and lentigo maligna), a congenital mole, Caucasian race, a previous cutaneous melanoma, a family history of cutaneous melanoma, immunosuppression, sun sensitivity, and excessive sun exposure. Selective screening and appropriate treatment of individuals who have these risk factors may reduce the morbidity and mortality of cutaneous melanoma. (<i>JAMA</i>1987 258:3146-3154)
Glass Fiber Dissolution in Simulated Lung Fluid and Measures Needed to Improve Consistency and Correspondence to In Vivo Dissolution
Authors: Stephanie M. Mattson
Journal: Environmental Health Perspectives (1994)

The dissolution of a range of glass fibers including commercial glass and mineral wools has been studied using a modification of Gamble's solution in a flow system at pH 7.4 and 37°C.Dissolution has been followed by weight loss, effluent analysis, and morphology change of fibers and bulk glass.Flow per glass surface area can strongly affect both dissolution rate and morphology due to the effect of the dissolution process on the fluid.Effluent pH is shown to be a guide for choice of optimum flow/area conditions.These conditions provide measurable concentrations of dissolved glass in the effluent while maintaining their concentrations below the point at which they significantly affect the dissolution process.SiO2 and A1203 vary widely in the extent to which they are involved in the leaching process, which removes alkalis, alkaline earths, and B203.This makes analysis of a single component in the effluent unsuitable as a means of comparing the dissolution rates of a wide range of compositions.
Anesthesia sends shivers up one's spine, but hypothermia per se may not be culprit
Authors: C. A. Raymond
Journal: JAMA (1988)

WHO SHIVERS, but not from cold? Who is cold, but doesn't shiver? These riddles have puzzled anesthesiologists for years. Now, a team of investigators may have turned some of the accepted answers on their heads. When Daniel I. Sessler, MD, was a resident in anesthesiology at the University of California, Los Angeles (UCLA), School of Medicine in the early 1980s, he proposed an explanation for why a substantial proportion of the estimated 25 million patients who undergo surgery each year are stricken with severe tremors during postoperative recovery. The shivering phenomenon, first described in 1950, sometimes dangerously boosts a patient's heart rate and blood pressure, pulls apart incisions, or damages surgical repairs. Common wisdom has it that the tremors arise because core body temperature drops during the patient's partially clothed sojourn through the cool confines of the surgical suite, inhaling cold gases and receiving cold intravenous fluids. Sessler had a
Role of sinusoidal endothelial cells of the liver in concanavalin A-induced hepatic injury in mice
Authors: P Knolle
Journal: Hepatology (1996)

CD4+ T lymphocytes have been identified as being responsible for organ damage in the murine model of experimental liver injury induced by intravenous injection of concanavalin A (Con A). Liver sinusoidal endothelial cells (SEC) and Kupffer's cells (KC) are among the first cells that come into contact with lymphocytes in the liver sinusoid. We aimed to investigate the respective role of these cell populations in the initial steps of T-cell-mediated liver injury in Con A-induced hepatitis. By electron microscopy, we could show that intravenously applied Con A bound predominantly to SEC but not to KC. KC depletion by gadolinium chloride treatment of mice did not result in protection from liver injury, indicating that KCs are not primarily involved in the generation of liver injury. We could show that a CD4+ T-cell line (LNC.2) displayed selective cytotoxicity toward SEC (>50%) but not KC (12%) or fibroblasts (5%) in the presence of Con A in vitro. Microscopic observation revealed that the SEC monolayer was rapidly destroyed by LnC2 in the presence of Con A. Specificity of the Con A-induced cytotoxicity was shown by the ability of a competitive ligand, methyl-α-D-mannopyranoside, to reduce T-cell-mediated cytotoxicity to SEC by more than 50%. Tumor necrosis factor α (TNF-α) was produced by LnC2 in high amounts after Con A stimulation (>6 ng/mL), but antiserum to TNF-α did not reduce LnC2-mediated cytotoxicity toward SEC. In conclusion, we could show for the first time that liver SECs have accessory function and are selectively destroyed by CD4+ T lymphocytes in the presence of Con A. We speculate that SEC damage is an early event in T-cell-mediated liver injury recruiting T lymphocytes from the sinusoidal circulation. Loss of the SEC barrier function then exposes underlying hepatocytes to further attack by activated T lymphocytes. These results offer a model of initiating events in T-cell- mediated liver diseases, such as viral or autoimmune hepatitis, and suggest an important role for sinusoidal endothelial cells.
Abrupt withdrawal of maintenance methadone
Authors: M. H. Lipkowitz
Journal: JAMA (1971)

Sudden withdrawal from high levels of methadone hydrochloride can be anticipated when patients in methadone maintenance programs are arrested, hospitalized, or stopped in their treatment by other extraneous reasons. While there is general concern that such abrupt withdrawal can be dangerous, the four cases which are presented indicate that the principal responses are subjective, with little in the way of objective physical reactions.
Faculty responsibility for the competence of new physicians
Authors: R. L. Egan
Journal: JAMA (1976)

Since 1906, the American Medical Association, through its Council on Medical Education, and since 1942, in a partnership with the Association of American Medical Colleges, through the Liaison Committee on Medical Education, has accredited medical schools in the United States. Accreditation has been and is a procedure to assure that the new physician will have received an education appropriate for the responsibilities confronting him upon graduation. Parallel with the development of procedures to accredit medical schools, each of the states has, through legislation, established requirements for licensure. These requirements in general require graduation from an accredited medical school, the completion of one year of graduate medical education, and the passing of an examination. Licensure is intended to assure that the new physician is competent to practice medicine. Changes in medical education, accreditation, and licensure during the past 70 years have been numerous. The inadequate schools described by Flexner are now
ACC/AHA 2013 Methodology for Developing Clinical Data Standards: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Data Standards
Authors: Robert C. Hendel, Biykem Bozkurt, Gregg C. Fonarow, Jeffrey P. Jacobs, Judith H. Lichtman, Eric E. Smith, James E. Tcheng, Tracy Y. Wang, William S. Weintraub
Journal: Circulation (2013)
MET409, a potent, non-bile acid sustained FXR agonist, improves NAFLD activity score and exerts anti-fibrotic effects in a diet-induced obese mouse model of biopsy-confirmed fibrosing NASH
Authors: Sanne Veidal, Michael Feigh, Kirstine Tølbøl, Nicholas Smith, Brandee Wagner
Journal: Journal of Hepatology (2020)