tbuckley/cabot-search huggingface dataset:
Transparent reporting of a multivariable prediction model for individual prognosis or diagnosis (TRIPOD): the TRIPOD statement
Authors: G. S. Collins, J. B. Reitsma, D. G. Altman, K. G. M. Moons
Journal: BMJ (2015)

Prediction models are developed to aid health care providers in estimating the probability or risk that a specific disease or condition is present (diagnostic models) or that a specific event will occur in the future (prognostic models), to inform their decision making. However, the overwhelming evidence shows that the quality of reporting of prediction model studies is poor. Only with full and clear reporting of information on all aspects of a prediction model can risk of bias and potential usefulness of prediction models be adequately assessed. The Transparent Reporting of a multivariable prediction model for Individual Prognosis Or Diagnosis (TRIPOD) Initiative developed a set of recommendations for the reporting of studies developing, validating, or updating a prediction model, whether for diagnostic or prognostic purposes. This article describes how the TRIPOD Statement was developed. An extensive list of items based on a review of the literature was created, which was reduced after a Web based survey and revised during a three day meeting in June 2011 with methodologists, health care professionals, and journal editors. The list was refined during several meetings of the steering group and in e-mail discussions with the wider group of TRIPOD contributors. The resulting TRIPOD Statement is a checklist of 22 items, deemed essential for transparent reporting of a prediction model study. The TRIPOD Statement aims to improve the transparency of the reporting of a prediction model study regardless of the study methods used. The TRIPOD Statement is best used in conjunction with the TRIPOD explanation and elaboration document. To aid the editorial process and readers of prediction model studies, it is recommended that authors include a completed checklist in their submission (also available at www.tripod-statement.org). To encourage dissemination of the TRIPOD Statement, this article is freely accessible on the <i>Annals of Internal Medicine</i> Web site (www.annals.org) and will be also published in <i>BJOG</i>, <i>British Journal of Cancer</i>, <i>British Journal of Surgery</i>, <i>BMC Medicine</i>, <i>The BMJ</i>, <i>Circulation</i>, <i>Diabetic Medicine</i>, <i>European Journal of Clinical Investigation</i>, <i>European Urology</i>, and <i>Journal of Clinical Epidemiology</i>. The authors jointly hold the copyright of this article. An accompanying explanation and elaboration article is freely available only on www.annals.org; <i>Annals of Internal Medicine</i> holds copyright for that article.
P09.35 Gross total resection of glioblastoma multiforme: influencing factors &amp; survival outcomes - a single centre experience
Authors: S. Mukherjee, J. Start, N. Burnet, G. Sivakumar, S. Thomson, R. Corns
Journal: Neuro-Oncology (2017)

Objectives: We studied factors influencing the extent of resection of glioblastoma multiforme (GBM) and attendant overall survival (OS) and functional performance. Methods: Retrospective data were collected on 100 consecutive patients who underwent debulking surgery for histologically proven GBM between September 2013 and February 2016 by sub-specialty surgeons at a single institution. Survival data and correlations were calculated using the Kaplan-Meier and linear regression analyses. Results: Gross total resection (GTR) with tumour residuum<0.175 cm3 was achieved in 66% of small tumours (<37.2 cm3) whilst in 34% of large tumours (>37.2 cm3) (p<0.05). Volume of tumour residuum was significantly correlated with pre-operative tumour volume (p = 0.01). GTR was achieved in 53% versus 29% of tumours involving single versus multiple lobes respectively (p = 0.08). Comparison of 24 patients with complete resection versus 52 patients with near total resection (thin rim of enhancement) versus 24 patients with subtotal resection did yield significant differences in survival (15.9 vs 13.2 vs 11.1 months, respectively, Log-Rank p = 0.03). We also found significant correlation between post-operative tumour volume and overall survival. Conclusions: Factors influencing GTR include pre-operative tumour size and involvement of more than one lobe. Categorising patients with respect to complete, near total and subtotal resection did yield small but significant differences in survival, and the size of post-operative tumour volume is correlated with survival.
Vincristine Neurotoxicity
Authors: SUSAN ROSENTHAL
Journal: Annals of Internal Medicine (1974)

Vincristine sulfate, a useful agent in treatment of childhood leukemia, lymphoma, and a great variety of solid tumors, is a potentially serious neurotoxin. A mixed sensory-motor neuropathy is the most common manifestation of drug toxicity, but other effects have been attributed to this drug, including seizures, mental changes, orthostatic hypotension, inappropriate secretion of antidiuretic hormone, and potentiation of preexisting neurological disease. A critical review of published data does not confirm a causal relation between vincristine administration and these neurotoxic effects. Only in the cases of hyponatremia that are secondary to inappropriate secretion of antidiuretic hormone has a convincing causal relation been established.
P01.144 TTFields for newly diagnosed Glioblastoma: Impact of consultation strategy
Authors: A Haj, C Doenitz, C Hohenberger, A Brawanski, M A Proescholdt
Journal: Neuro-Oncology (2018)

After a positive randomized clinical trial showing significant survival benefits, Tumor Treating Fields (TTFields) have been implemented in the management of newly diagnosed glioblastoma (GBM). However, this treatment critically depends on patient’s motivation for this therapy plus a high compliance rate. Hair shaving, skin care, application of the arrays and carrying the power source in daily life requires an adequate level of commitment from the patients and their relatives. Based on our clinical experience, it became evident that structure and didactics of the initial and follow up consultations profoundly influence these parameters. In the primary time segment of 4 months after publication of the EF-14 trial results, we have informed our patients during inpatient stay shortly after resection and histological diagnosis about this treatment option. After initially unsatisfactory experiences regarding patient motivation for TTFields treatment, we have initiated a designated outpatient clinic for TTFields therapy consultation in analogy to consultation for radiation and chemotherapy. In this setting, we allow about one hour for each patient appointment to meet the need for information about mode of action, clinical efficacy, compliance aspects as well as practical issues with the device application. We developed a standardized patient education concept for intense and open communication about the disease, prognosis and treatment options with advantages and drawbacks. Using the initial consultation strategy, we were unable to motivate any patients with newly diagnosed GBM to get TTFields treatment. In contrast, after changing the setting into a more patient - centered approach, and standardization of the consultation didactics, 68% of all newly diagnosed patients agree to apply TTFields therapy. In addition, the average compliance rate was well above 90%, which ensures clinical efficacy of this treatment modality. Motivation for and compliance to TTFields therapy may critically depend on the consultation setting and strategy.
The Milroy Lectures on the Earth in Relation to the Preservation and Destruction of Contagia: Delivered at the Royal College of Physicians of London
Authors: G. V. Poore
Journal: BMJ (1899)

Jow&z 52 may therefore, describe two forms of right duodenal hernia, the iormer as hernia mesenterico-parietalis parajejunalis, and the latter as hernia mesenterico-parietalis paraduodenalis.In both varieties the anterior margin of the sac contains the
Nonmenstrual toxic shock syndrome: the growing picture
Authors: A. L. Reingold
Journal: JAMA (1983)

Toxic shock syndrome (TSS), formerly known as staphylococcal scarlet fever, has been recognized as a distinct clinical entity since 1927.<sup>1</sup>While, in retrospect, one or more of the cases in the series of Todd et al<sup>2</sup>may have been associated with menstruation, it is clear that most of the earliest reported cases of TSS were nonmenstrual. The number of such cases reported before 1980 was small, however, and it was not until TSS and its now well-verified association with menstruation and tampons were the subject of widespread publicity that physicians were stimulated to look for and report cases. The case described by Jacobson and colleagues (p922) nicely illustrates a number of important aspects of a disease in which the clinical and epidemiologic dimensions continue to expand. As has been noted previously in postoperative and postpartum TSS cases,<sup>3-13</sup>the incubation period can be remarkably short, frequently 12 to
Editorial: Transfer of registrars.
Journal: BMJ (1973)

Transfer of RegistrarsAfter 25 years of undisputed supremacy within the N.H.S. the teaching hospitals-and especially those in London-are at last facing a serious challenge to their power and influence.Further increase in their numbers of registrars and senior registrars is not only to be halted, it is to be reversed; indeed by March 1974 the number of these posts in teaching institu- tions in England and Wales is to have been reduced by 59.This is the initial stage in a series of cuts recommended by the
Hematology
Authors: J. McCullough
Journal: JAMA (1980)

<h3>Anticoagulants</h3> During the 1970s, blood transfusion therapy medicine underwent remarkable evaluation. The acid-citrate-dextrose (ACD) anticoagulant used since the 1940s was discarded in favor of the citrate-phosphate-dextrose (CPD) anticoagulant, which provides better RBC survival and oxygen-carrying capacity. Conversion to another anticoagulant preservative, CPD-adenine (CPD-A), is under way.<sup>1</sup>Adenine improves RBC viability, extending the shelf life of blood from 21 to 35 days, a most dramatic improvement. Red blood cells maintain their oxygencarrying capacity during storage in CPD-A as well as in the CPD presently used. Other blood components prepared from blood collected in CPD-A function normally. <h3>Blood Component Therapy</h3> In the use of specific components for specific clinical situations, blood component therapy has become the standard form of transfusion therapy. Whole blood is used only when the patient requires both RBCs (for oxygen transport) and volume replacement. Since most patients receive RBCs, the plasma can be used to prepare coagulation-factor
PSYCHIATRY IN INDUSTRY
Authors: FREDERICK W. DERSHIMER
Journal: American Journal of Psychiatry (1946)

I. Industrial management is open-minded about the application of psychiatry in industry provided the psychiatrist is willing to learn about industry and its problems. In our own experience, we find that top management increasingly asks for psychiatric help in personnel problems. This, in time, will result in improved mental health throughout the entire organization, if our advice is sound. This—the top—is the place preventive psychiatry must start to be effective. II. It seems obvious that the basic causes of all functional mental disease exist, grow and cause some manifestations in normal people; that normal people are the hosts or carriers from whom unfortunate individuals contract the more serious, recognized forms of this group of ills. Until we learn far more than we now know about this part of the cycle, we cannot hope to learn how to treat and prevent mental disease. Industry offers the psychiatrist an unique opportunity to explore this important area, now one of almost complete darkness. III. We have already developed a psychotherapeutic approach with which, in several hundred cases of psychoneuroses and a few psychoses, it is possible to obtain lasting good results with a very few interviews while the patients continue at their regular work.
Leukemia and lymphoma
Authors: P. G. Rigby
Journal: JAMA (1966)

Ninety-two families whose probands had leukemia or lymphoma and 69 control families have been studied with an intensive interview technique. Twenty-one multiple family instances of leukemia and lymphoma have been recorded, and an impressive aggregate of neoplastic involvement was observed. No difference was detected in the exposure to various animal and other environmental agents by the methods employed between the leukemialymphoma group and the control group. The occurrence of leukemia and lymphoma was 2.5 times more frequent in the family members of the leukemia-lymphoma proband group than in the control group. These data suggest that hereditary factors are important in the etiology of leukemia and lymphoma.
Abstract 3315: Workplace program that offers annual fecal immunochemical testing improves adherence to colorectal cancer screening guidelines
Authors: Carmen H. Tong, Anita Satish, Maren S. Fragala, Lance A. Bare, Charles E. Birse
Journal: Cancer Research (2019)

Abstract Background: Although regular screening reduces the incidence and mortality of colorectal cancer, ~ 35% of eligible adults remain non-adherent to screening guidelines. We asked if a workplace screening program, using a non-invasive fecal immunochemical test (Insure FIT), would improve adherence to guidelines. Methods: An employer-sponsored program provided eligible employees (age 50-75 years) the opportunity to participate in colorectal cancer screening. InSure FIT collection kits were mailed annually to: (i) newly eligible employees, (ii) new hires, (iii) those who had participated the previous year and (iv) those who requested testing. Employees returned kits by mail for quantitative detection of human hemoglobin in fecal samples. Those with positive test results were contacted by phone and mail with a recommendation to contact their physician for follow up diagnostic testing. Using a limited data set of health plan claims, we identified those employees, with continuous medical coverage over the 5-year study period (2013-2017), who were adherent to current screening guidelines (colonoscopy any year or FIT every year). Colonoscopy procedures were identified in professional services and outpatient event files using current procedural terminology (CPT) codes. Results: Approximately a third (32.7%; 1,858/5,686) of eligible employees participated in the program. Some 42.7% (794/1,858) of participants underwent colonoscopy over the 5-year study period. An additional 15.9% (296/1,858) were tested with InSure FIT all 5 years. In total 58.7% (1,090/1,858) of participants were adherent to guidelines (colonoscopy any year or annual FIT). In comparison, only 34.6% (1,323/3,828) of non-participants were adherent to guidelines. ParticipantsNon-ParticipantsTotal1,8583,828Mean age, y (SD)55.9 (4.2)55.7 (4.3)Female, n (%)1,314 (70.7%)2,470 (64.5%)Adherent to screening guidelines, n (%)1,090 (58.7%)1,323 (34.6%) Conclusion: Participants in an employer-sponsored FIT program had 24% higher adherence to guidelines for colorectal cancer screening compared to non-participants. Citation Format: Carmen H. Tong, Anita Satish, Maren S. Fragala, Lance A. Bare, Charles E. Birse. Workplace program that offers annual fecal immunochemical testing improves adherence to colorectal cancer screening guidelines [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3315.
Atlas of Clinical Medicine.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Erratum
Journal: BMJ (1898)

a Queries, answers, and communications relating to subjects to wUhich cpecial departments of the BRITISH MBDICAL JOURNAL are directed will be found uncer their respective headings. QIERIES.Civis asks where he is likely to obtain authentic information for esti- mating the relative monetary compensation for the loss of an eye, limb, or finger, computing total permanent disablement or death at ;30oo.J. H. would be glad to know of a suitable institution for a boy aged 81 years, who has been having epileptic attacks regularly for the last four years, and whose mental condition is becoming linpaired.J. I. M. asks where he can obtain information dealing with the proper proportions of the human body, for example, relative circumference of chest at nipples and abdomen at the level of the navel.SENILITY will be glad to be informed whether there is anly home or hospital, in Sussex if possible, to which an aged gentlemen over 8o, who is suffering from senile dementia, could be sent.His family are in straitened circumstances, and at present have to employ a day and night nurse to look after him.They are prepared to pay the sum of 2 guineas per week to have him taken care of.G. G. writes: Is there any home or other institution in which we could place a woman, aged 40, epileptic, and partly imbecile, but otherwise strong and healthy ?Her friends could contribute 4S. or 5S. a week, but it must be mainly a work of charity.When not suffering from fits she can do a little work.Cumberland or its neighbourhood preferred, so that her friends can visit occasionally.A MEMBER writes: I should like if possible to have definite information on the following points: What is the largest dose of iodide of potassium -if any-which can be given for an indefinite time-say years-to a rheumatic'patient ?My patient, a married woman, aged 30, improves under its use, but gets worse immediately on stopping it.The rheum- atism is articular.Can anyone speak well of the hydro-electric treatment of rheumatism?Could it be carried out successfully with- out complete immersion, and would an ordinary Spamer's battery be of any use ?
Oral contraceptives and blood pressure
Authors: I. R. Fisch
Journal: JAMA (1977)

Both cross-sectional and longitudinal analyses of data from 13,358 women showed that oral contraceptive use is associated with a slight but statistically significant (<i>P</i>&lt;.05) rise in mean blood pressure, which is reversible. The age-adjusted proportion of oral contraceptive users with a blood pressure over 140/90 mm Hg was about three times that of nonusers. These findings are caused by a uniform upward shift in the blood pressure distribution of oral contraceptive users compared to nonusers. Women continuing oral contraceptive use had no appreciably greater change in blood pressure between two visits than persistent nonusers. The clinical implications of a mild contraceptive-induced blood pressure elevation (systolic, 5 to 6 mm Hg; diastolic, 1 to 2 mm Hg) remain unsettled but disturbing. (<i>JAMA</i>237:2499-2503, 1977)
Toxic Effects of Lead in the Developing Nervous System: In Oculo Experimental Models
Authors: Barry J. Hoffer, Lars Olson, Michael R. Palmer
Journal: Environmental Health Perspectives (1987)

Modern man is chronically exposed to lead in the biosphere at levels several orders of magnitude higher than the natural level that once existed. There is much concern about the possible adverse effects of this population-wide, low-level lead exposure, particularly on the developing organism, wherein the central nervous system may be one primary target. We have developed in oculo test systems, which permit temporal and spatial discrimination of possible effects of lead and other potential neurotoxic agents in the environment on the developing central nervous system as well as on different types of peripheral nerves in the adult. In one experimental protocol, defined areas of the fetal rat brain are grafted to the anterior chamber of the eye of adult rat recipients that are exposed to lead. Such grafts will become vascularized from the host iris and continue developing in oculo. Thus, grafted brain tissue and host brain will share circulation and therefore be exposed to similar amounts of lead. Studies of cerebellar grafts revealed that, although there was a normal gross cytological development in the presence of lead, there was a marked and permanent impairment of spontaneous discharge rates of the grafted Purkinje neurons as observed with electrophysiological techniques long after cessation of lead treatment. The host Purkinje neurons were not affected. A similar, although less dramatic, impairment of cerebellar function could be subsequently demonstrated in intact animals when newborn rats were given lead during the first 20 days of life and studied as adults.(ABSTRACT TRUNCATED AT 250 WORDS)
New Classification for Deaths and Injuries Involving Terrorism
Journal: JAMA (2002)

Classification of the deaths and injuries that occurred as the result of the events of September 11, 2001, presented CDC's National Center for Health Statistics (NCHS) with a dilemma. Under the current classification systems for mortality and morbidity, the World Health Organization's International Classification of Diseases, Tenth Revision (ICD-10) and the United States' International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM), deaths and injuries associated with acts of terrorism could not be identified uniquely.
PROFESSOR VIRCHOW IN ENGLAND.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal