tbuckley/cabot-search huggingface dataset:
Cutaneous sporotrichosis in forestry workers. Epidemic due to contaminated Sphagnum moss
Authors: K. E. Powell
Journal: JAMA (1978)

In December 1975 and January and February 1976, an epidemic of cutaneous sporotrichosis occurred in Mississippi among forestry workers and other persons exposed to sphagnum moss used in packing pine seedlings. Seventeen cases were identified, 15 of which were from patients who had been exposed to sphagnum moss from a single source. Attack rates were significantly higher among workers exposed to this moss than among those not exposed.<i>Sporothrix schenckii</i>was cultured from the implicated batch of sphagnum moss but not from other batches. The source of contamination of the sphagnum moss that caused this epidemic and sphagnum moss associated with similar epidemics is unknown. One worker without cutaneous sporotrichosis may have had asymptomatic pulmonary sporotrichosis. (<i>JAMA</i>240:232-235, 1978)
Continuing Education Opportunities for Physicians
Journal: JAMA (1988)

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Twelfth Annual Report of the State Board of Health of Ohio.
Journal: JAMA (1898)

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VITAMIN BALANCE
Journal: JAMA (1930)

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Miscellaneous II
Authors: J. -C. Farkas, Th. Lecompte, S. Combe, C. Laurian, M. M. Samama, J-M. Cormier, H. Romo, A. Maldonado, C. Montenegro, J. J. Rubio, C. Chamorro, M. A. Romera, M. Nieto, M. A. Estecha, J. M. Molina, M. Jimenez Lendinez, C. Pascual, V. Cerdeno, S. Yus, J. Lopez, R. Denia, J. Anon, A. Minuto, A. Sicignano, S. Vesconi, C. Foroni, A. Riboni, F. Hernández Altemir, E. Voß, R. Strauß, E. G. Hahn, M. U. Schneider, A. Gianotti, G. Simoni, A. Ardia, A. de Lassence, J. Beaune, J. Fleury, E. Escudier, C. Cordonnier, N. Roche, B. Verdière, G. Moret, D. Boule, L. Ngwintin, C. Bazin, F. Fraisse, J. Klementaviĉienê, A. Lukoŝeviĉiutê, J. Xirgu, P. Torrabadella, J. Klamburg, J. M. Payá, A. Galan, P. Velasco, A. J. Challiner, G. B. Smith, Finn Redke, Sven Björkman, Einar Vernersson, P. Ferrer, C. Tormo, G. Albiñana, E. Vega, R. Sesma, C. Pérez, J. Arroyo, I. García, A. Sánchez, F. W. Santman, A. F. Grootendorst, P. F. Hulstaert, C. Wigant
Journal: Intensive Care Medicine (1992)
Critical Windows of Exposure for Children's Health: The Reproductive System in Animals and Humans
Authors: Jon L. Pryor, Claude Hughes, Warren Foster, Barbara F. Hales, Bernard Robaire
Journal: Environmental Health Perspectives (2000)

Drugs and environmental chemicals can adversely affect the reproductive system.Currently, available data indicate that the consequences of exposure depend on the nature of the chemical, its target, and the timing of exposure relative to critical windows in development of the reproductive system.The reproductive system is designed to produce gametes in far greater excess than would seem to be necessary for the survival of species.Ten to hundreds of millions of spermatozoa are generated daily by most adult male mammals, yet very few of these germ cells succeed in transmitting their genetic material to the next generation.Although the number of oocytes produced in mammalian females is more limited, and their production occurs only during fetal life, most ovaries contain several orders of magnitude more oocytes than ever will be fertilized.Toxicant exposures may affect critical events in the development of the reproductive system, ranging from early primordial germ cell determination to gonadal differentiation, gametogenesis, external genitalia, or signaling events regulating sexual behavior.Although there are differences between the human reproductive system and that of the usual animal models, such models have been extremely useful in assessing risks for key human reproductive and developmental processes.The objectives for future studies should include the elucidation of the specific cellular and molecular targets of known toxicants; the design of a systematic approach to the identification of reproductive toxicants; and the development of sensitive, specific, and predictive animal models, minimally invasive surrogate markers, or in vitro tests to assess reproductive system function during embryonic, postnatal, and adult life.
Meeting report from the Third European Congress of Virology, 1-5 September 2007 in Nuremberg, Germany
Authors: Collective Editorial team
Journal: Eurosurveillance (2007)

Nuremberg was the third European city to host the European Congress of Virology in September this year (http://www.eurovirology.org). Some 1,500 scientists from Europe and elsewhere came together to share their knowledge on basic and applied research in clinical, veterinary and plant virology. The main focus was on human pathogenic viruses, providing a platform where basic research and clinical application came into contact. The topics covered all areas of research in virology, from basic molecular biology and immunology to epidemiology, vaccine development, and diagnostics. For this meeting report, the Editorial team has selected some of our highlights out of the many excellent keynote lectures and workshop contributions.
Author’s correction for Euro Surveill. 2017;22(32)
Authors:  Eurosurveillance Editorial Team
Journal: Eurosurveillance (2017)

© This work is licensed under a Creative Commons Attribution 4.0 International License. Closure This is a corrected article applying to the following content: Cyclosporiasis in travellers returning to the United Kingdom from Mexico in summer 2017: lessons from the recent past to inform the future
Some Account of the Operations Practised in the Nineteenth Century for the Relief of Tension of the Eyeball, Glaucoma, etc
Authors: J. V. Solomon
Journal: BMJ (1863)

That the various questions arising on the subejects of diag-nosis, prognoosis, etiology, and contagion, admit of more satisfiictory solution; and That treatment having muore reliable indications i)econmes less empirical, more rational, and more success- ful.
BOOK REVIEWS
Authors: A. J. KOLETSKY
Journal: JNCI Journal of the National Cancer Institute (1992)

Journal Article BOOK REVIEWS Get access Geriatric Oncology Lodovico Balducci , Gary H. Lyman , William B. Ershler , eds., Philadelphia : J. B. Lippincott , 1992 . 409 pp., illus. $89.50., ISBN 0-397-51210-4 ALAN J. KOLETSKY, M.D. ALAN J. KOLETSKY, M.D. Comprehensive Cancer Center, JFK Medical CenterAtlantis, FL 33437 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 84, Issue 21, 4 November 1992, Pages 1662–1663, https://doi.org/10.1093/jnci/84.21.1662 Published: 04 November 1992
Abstract 2722: Large Scale Mutation Discovery Screen Identifies Functionally Variant UGDH Alleles in Patients with Atrioventricular Valve Defects
Authors: Jeroen Bakkers, Sonja Chocron, Victor Gouriev, Kelly Smith, Ronald Lekanne dit Deprez, Irene C Joziasse, Pieter A Doevendans, Barbara J Mulder, Melanie Simpson, Joseph Barycki, Edwin Cuppen
Journal: Circulation (2007)

Background: Congenital heart defects are the most common birth defects. Although genetic dispositions are believed to cause CHDs, only few genes have been identified that harbour mutations causing such defects. Studies in model organisms have identified many essential genes for cardiac development. UDP-glucose dehydrogenase (UGDH) enzymatic activity is required for the signal transduction of FGF and Wnt ligands and zebrafish jekyll/ugdh mutations lack AV valves. Methods and Results: From literature candidate genes were selected that are essential for AV canal-, septum-, and valve formation. By large scale sequencing we analysed the coding regions of 36 candidate genes in 192 patients with reported AVSDs. As a result we identified 457 genetic variations of which 207 variants are in flanking non-coding regions, 156 variants are in coding regions but silent and 94 variants are non-synonymous variants that alter the protein sequence. Comparison with the available databases such as HapMap and screening 350 control individuals resulted in the validation of 49 non-synonomous missense mutations in 23 genes only present in the patient group. These included novel GATA4 missense mutations (R285C and M224V) located in the highly conserved DNA binding domains, which by in vitro analysis significantly reduce transcriptional activity of the protein. Three patients with mitral valvar prolapse and mitral regurgitation were identified with novel missense mutations in the UDP-glucose dehydrogenase (UGDH) gene (R141C and E416D). In vitro experiments demonstrated a negative affect on enzyme activity and stability by a change in protein conformation. Furthermore, experiments in zebrafish jekyll/ugdh mutants showed that UGDH R141C and UGDH E416D couldn’t rescue the defects in AV formation demonstrating an inactivating effect of these missense mutations in vivo. Conclusions: A model organism based candidate gene screen in CHD patients resulted in the identification of novel functional missense mutations in the UGDH gene not previously implicated in congenital heart defects.
125P Components of the PI3K/Akt pathway as prognostic factors in metastatic HER2-positive breast cancer treated with trastuzumab
Authors: C. Veenstra, S. Ellegård, G. Pérez-Tenorio, V. Fagerström, J. Gårsjö, K. Briedis, M. Sundqvist, A. Malmström, S. Wingren, O. Stål
Journal: Annals of Oncology (2016)
Preventive medicine and public health
Authors: W. H. Foege
Journal: JAMA (1992)

The disciplines of preventive medicine and public health are not meeting their potential in reducing morbidity and mortality. Public health successes may have obscured our failures. The world has not had the level of medical care that we take for granted in this country, yet global life expectancy increased from 50 years in 1960 to an estimated 60 years in 1990.<sup>1-3</sup>India actually reported an improvement of life expectancy of 6 months per year from 1956 to 1978.<sup>4</sup> Reductions in infant mortality rates may be even more impressive. The infant mortality rate for the entire world has fallen from about 125 deaths per 1000 live births in 1960 to about half that number in the early 1990s.<sup>1-3</sup>Those areas at highest risk have fallen from 48 countries with infant mortality rates of 150 or higher in 1960 to only six countries remaining in this category by 1990.
Establishment of a cell line from a woodchuck hepatocellular carcinoma
Authors: Masashi Unoura, Kenichi Kobayashi, Kenichi Fukuoka, Fumiaki Matsushita, Hideo Morimoto, Tohru Oshima, Shuichi Kaneko, Nobu Hattori, Seishi Murakami, Hiroshi Yoshikawa
Journal: Hepatology (1985)

A new cell line derived from a woodchuck hepatocellular carcinoma serially transplanted in athymic nude mice has been established and named WH257GE10. The original tumor in the nude mouse system produces woodchuck hepatitis surface antigen and albumin. In addition, woodchuck hepatitis virus DNA is integrated into cellular DNA. Adaptation of the cells to the in vitro culture condition was completed after 15 months with the doubling time of 40 hr. The morphologic features of the cell by light microscopy are of an epithelial type. The modal chromosome number is 36 and the karyotype is mainly metacentric, similar to that observed in normal woodchuck liver cells. Ornithine and tyrosine aminotransferase activities were detected. Production of albumin was demonstrated in the cytoplasm by indirect immunofluorescence. Integration of woodchuck hepatitis virus DNA was shown by Southern blot analysis, although the secretion of woodchuck hepatitis surface antigen was not detected. This cell line provides an excellent in vitro model to study human hepatocellular carcinoma related to hepatitis B virus.
The Physician's Art: An Attempt to Expand John Locke's Fragment De Arte Medica
Journal: JAMA (1934)

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EFFECTS OF REMOVAL OF LARGE PORTIONS OF THE DIGESTIVE TRACT.
Journal: JAMA (1900)

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Enzymes.
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Antibiotic Combinations
Authors: Wilfred F. Jones, Maxwell Finland, Clare Wilcox, Ann Najarian, Mildred W. Barnes
Journal: New England Journal of Medicine (1957)

Antibacterial Action of Plasma after Ingestion of Tetracycline, Erythromycin, Oleandomycin, Spiramycin and Combinations of Tetracycline and Each of the Other 3 AntibioticsThe activity of the antibiotics under study was compared in vivo in two ways: as single doses of 1.0 gm. of each of the 4 individual agents and equal total amounts (0.5 gm. each) of tetracycline in pairs with each of the other 3 drugs; and as a single dose of 500 mg. of tetracycline alone compared with the same amount of this antibiotic combined with 250 mg. of either erythromycin, oleandomycin or spiramycin. The doses were all . . .
Adam Politzer, (1835-1920) otolaryngologist
Journal: JAMA (1969)

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From Vitamin to Hormone
Journal: JAMA (1973)

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Numerical Errors and Addition of a Sentence
Authors: Pim Cuijpers
Journal: JAMA (2019)

Gareth J. Walker, MBBS; James W. Harrison, PhD; Graham A. Heap, PhD; Michiel D. Voskuil, MD; Vibeke Andersen, MD; Carl A. Anderson, PhD; Ashwin N. Ananthakrishnan, MD; Jeffrey C. Barrett, PhD; Laurent Beaugerie, PhD; Claire M. Bewshea, MSc; Andy T. Cole, DM; Fraser R. Cummings, DPhil; Mark J. Daly, PhD; Pierre Ellul, PhD; Richard N. Fedorak, MD; Eleonora A. M. Festen, MD; Timothy H. Florin, MBBS; Daniel R. Gaya, DM; Jonas Halfvarson, MD; Ailsa L. Hart, PhD; Neel M. Heerasing, MBBS; Peter Hendy, MBBS; Peter M. Irving, MD; Samuel E. Jones, PhD; Jukka Koskela, MD; James O. Lindsay, PhD; John C. Mansfield, MD; Dermot McGovern, DPhil; Miles Parkes, DM; Richard C. G. Pollok, PhD; Subramaniam Ramakrishnan, MD; David S. Rampton, DPhil; Manuel A. Rivas, DPhil; Richard K. Russell, PhD; Michael Schultz, PhD; Shaji Sebastian, MD; Philippe Seksik, PhD; Abhey Singh, MBBS; Kenji So, MBBS; Harry Sokol, PhD; Kavitha Subramaniam, MBBS; Anthony Todd, MBChB; Vito Annese, MD; Rinse K. Weersma, MD; Ramnik Xavier, MD; Rebecca Ward, MSc; Michael N. Weedon, PhD; James R. Goodhand, MBBS; Nicholas A. Kennedy, MBBS; Tariq Ahmad, DPhil; for the IBD Pharmacogenetics Study Group