tbuckley/cabot-search huggingface dataset:
Nontraumatic plexitis and heroin addiction
Authors: Y. B. Challenor
Journal: JAMA (1973)

Brachial and lumbosacral plexitis were observed as new complications of intravenous injection of heroin-adulterant mixtures in 13 patients (eight with brachial and five with lumbosacral plexitis). Clinical features included monoparesis with impaired sensation and hyporeflexia in the involved limb. Severe causalgia-like pain was a frequent symptom for lowerextremity lesions. Electrodiagnostic studies showed denervation in the weak limb, with localization of the causative lesion at a plexus rather than at a radicular or peripheral nerve level in 12 patients. One patient showed a radicular localization. The lesions appeared to be at least partially reversible. A direct toxic effect of the injectant or hypersensitivity reactions are possible causes.
Convolutional neural networks of H&amp;E-stained biopsy images accurately quantify histologic features of non-alcoholic steatohepatitis
Authors: Francesco Paolo Casale, Michael D. Bereket, Rohit Loomba, Arun Sanyal, Stephen Harrison, Zobair M. Younossi, Catherine Jia, Marianne Camargo, Chuhan Chung, Mani Subramanian, Robert Myers, Eilon Sharon, Matthew Albert, Daphne Koller
Journal: Journal of Hepatology (2020)
Chest Injuries
Authors: Jack W. Love
Journal: JAMA (1975)

THORACIC injuries are seen in two broad categories: blunt trauma (also known as closed-chest injury) and penetrating trauma. The predominant type of injury likely to be seen in the emergency room depends on the patient population served. The large urban hospital, especially if it serves a ghetto area, will see a predominance of penetrating trauma. The smaller, more rural hospital, especially if it is near a highway, will see a predominance of blunt trauma. As might be expected, penetrating injuries associated with substantial organ involvement may require urgent treatment. Blunt trauma is often less urgent and more subtle. These two types of injuries will be considered separately. <h3>PENETRATING INJURIES</h3> Penetrating chest wounds generally are caused by knives and bullets. Experience has taught that the bulk of penetrating chest injuries, unlike penetrating abdominal injuries, can be managed without surgery. This implies that most of these injuries do not result in substantial
Endotoxin/Mediators
Authors: F. Schneider, Ph. Lutun, P. Bilbault, I. Runge, J. Robles, J. D. Tempé, C. Bernard, Y. Gillaux, R. Merval, A. Tedgul, J. C. Farkas, A. Cabié, C. Filling, J. M. Cavaillon, C. Laurian, J. M. Cormier, R. P. Bleichrodt, C. RosMan, G. Wübbels, W. Manson, Ba. van Goor, A. L. Scholte, K. Kooi, J. Grond, B. M. Hameter, P. Westra, F. L. van der Zande, A. A. T. M. M. Vinks, R. Lieuwen, D. J. Touw, J. A. M. de Haas
Journal: Intensive Care Medicine (1992)
MEDICAL NEWS
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AB0144 Studying of the efficiency of the synvisk in osteoartrosis
Authors: LG Groppa, MG Moshneaga
Journal: Annals of the Rheumatic Diseases (2001)

<h3>Background</h3> <h3>Objectives</h3> At present for improvement of life quality in patients with osteoartrosis is necessary to solve some problems: precluding of development of degenerative process in cartilage of affected joint, relieving of pain and improvement of the function of the joint. <h3>Methods</h3> For these aims we studied the efficiency of the chondroprotective drug Synvisk by Boenhringer Ingelheim in 25 patients with arthrosis of the knee in medium age of 61,2 ± 1,7 years, 16 women and 8 men, with duration of the disease 5,8 ± 0,9 years. <h3>Results</h3> Conform X-ray data the distribution of the patients by stages of the disease was as follow: I grade ? 20%, II grade ? 64%, and III grade ? 16%. In experimental group the drug was administered intraarticular by blind method in dose of 2,0 ml one time in a week, 3 injections for the course, which were repeated after 6 and 12 months. The control group was matched by gender, duration of disease and X-ray date; in this group was administrated placebo conforming same scheme. Evaluation of the effectiveness and tolerability of compared drugs was carried out in evolution of clinical (pain, functional index by Lesquesne, volume of movement on affected joints), X-ray parameters and functional methods (ultrasonography, scintigraphy with Te99m. In the basic group were mentioned decreasing of the pain intensity and improvement of the joint functions after single injection in one third of the patients, while in control groups similar cases were absent. After 3 courses of the treatment in the basic group the effects were obtained in 86,7% of the patients, including 33,3% very good effect, in 53,4% moderate effect and only in 13,3% the effects were absent. In control group there were no effect in 80% of the patients, and in 20% of the patients there were mentioned moderate effects; good effects were are not observed. <h3>Conclusion</h3> Thus, a presented result suggests that administration of Synvisk lead to significant improvement of the life quality in the patients with arthrosis of the knee.
<i>Caveat Scriptor</i>
Authors: Marcus Backer
Journal: New England Journal of Medicine (1958)

THE ways of culture are expected of a learned profession. In literature, above all else, the doctor should live up to such expectation. His written word, like the opinion of the judge on the bench, should be scrupulous, grammatically correct, lucid, logical and foolproof in its use of quotations and foreign language. It should certainly pass examination by a good high-school teacher as well as the editor. For "scripta manent": indelible is the stigma of the written word. And piercing, when deserved, is the sting of that old rapier, "si tacuisses, philosophus mansisses": if you had kept still, you might . . .
Contempo 1992
Journal: JAMA (1992)

A coin in a fountain. A rub of a lamp. A wish on a star. Only the most cynical among us refrain from dreaming of wishes come true. And even if our wishes are not granted, the act of defining hopes and dreams may begin the actual work of fulfilling them. This year, we gave our Contempo authors a chance to make a wish—three, in fact—that, if granted, would change medicine in the United States today. Many responded with wishes that were far reaching but not unrealistic. They tended to focus on political, social, and practice issues rather than clinical ones. No one, for example, wished for cures for cancer. A few hoped for an HIV vaccine; this was the only specific scientific advance on the wish lists. No one explicitly wished for billions of dollars for medical care or research. By far the most frequently mentioned wish was for
The Anatomy of the Nervous System: Its Development and Function.
Journal: JAMA (1953)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TRAUMATIC PNEUMOCEPHALUS
Authors: S. W. MILLER
Journal: JAMA (1931)

The tremendous increase in cranial injuries since the advent of the more rapid means of transportation, such as the automobile and airplane, has served to demonstrate the inadequacy of our knowledge of the nature, extent and treatment of certain of these injuries. We are reporting the following case because of the great damage sustained by the cerebrum with at least temporary infection, the associated introduction of air into the ventricles, operation and complete recovery. <h3>REPORT OF CASE</h3> W. F., a white man, aged 20, was admitted to the Lancaster General Hospital, Sept. 29, 1928, following an automobile accident. There was profuse nasal bleeding; both eyes were ecchymotic and numerous lacerations covered his face and hands. He was unconscious and very restless. Roentgenograms showed multiple fractures of the frontal bones with lines of fracture extending into both frontal sinuses and both orbital plates (figs. 1 and 2). One week elapsed before
Prostatic crystalloids
Authors: B D Bennett, W A Gardner
Journal: JAMA (1988)

Intraluminal crystalline structures having distinctive morphological characteristics were noted by Holmes<sup>1</sup>in 1977 in association with prostatic adenocarcinoma. In her series of 335 cases, she found these crystalloids in 23%. The structures were almost exclusively confined to malignant glands and were not seen in benign prostates. A study by Jensen et al<sup>2</sup>and a subsequent study by Ro et al<sup>3</sup>found crystalloids in approximately 10% of cases of prostate cancer, suggesting that Holmes' 23% was an overestimation. These differences, however, are probably related to sampling, since recent investigations using whole-organ tissue sections revealed crystalloids in the majority of cases of prostatic adenocarcinoma.<sup>4</sup>Although most commonly seen in well-differentiated neoplasms, prostatic crystalloids have been noted in metastatic sites.<sup>5</sup>They have also been found in fine-needle aspirates of the prostate (G. F. Worsham, MD, B. W. Kellough, MD; B. S. Collins, MD, unpublished data, 1987). The significance
Influence of metronidazole resistance on efficacy of quadruple therapy for Helicobacter pylori eradication Reply
Authors: M C BATESON, R W M V. D. HULST, A HOMAN, G N J TYTGAT, A V. D. ENDE, P ROORDA, J DANKERT
Journal: Gut (1998)

Influence of metronidazole resistance on eYcacy of quadruple therapy forHelicobacter pylori eradication
Ehrlichia
Authors: J. S. Dumler
Journal: JAMA (1991)

<h3>To the Editor.</h3> — During the recent sesquiannual meeting of the American Society for Rickettsiology and Rickettsial Diseases held in Galveston, Tex, several investigators presented data concerning human ehrlichiosis, a newly recognized human zoonosis. Also published in the April 24 issue of<i>JAMA</i>was a report<sup>1</sup>that was misleading and implied the discovery of the agent of human ehrlichiosis by me and my coworkers. In fact, the report concerns data we presented at the March 1991 annual meeting of the United States and Canadian Academy of Pathology, which details the pathology of several cases and the first documentation of an immunohistologically identified<i>Ehrlichia</i>in human tissues from one case of fatal ehrlichiosis. During the meeting of rickettsiologists, Jacqueline Dawson, MS, of the Centers for Disease Control, Atlanta, Ga, described the first isolation of<i>Ehrlichia</i>organisms from a patient in the United States.<sup>2</sup>Ms Dawson and her Centers for
THE TREATMENT OF ERYSIPELAS WITH THE SERUM OF ERYSIPELATOUS PATIENTS.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The 12th Report of the Human Renal Transplant Registry. Prepared by the Advisory Committee to the Renal Transplant Registry
Journal: JAMA (1975)

This report, the 12th, from the Renal Transplant Registry summarizes current results of kidney transplantation in man. There has been a trend toward increasing use of cadaveric sources for kidney transplantation. Results are summarized in five-year life-table analyses of recipient survival and graft function. Also, a summary of the results of special studies is provided. These include preparation of the recipient for transplantation by nephrectomy in various disease states, comparison of simple flushing with machine perfusion in cadaveric kidney storage, results of transplantation in the pediatric recipient, and the development of malignant neoplasm in graft recipients. A large study relating typing to graft function presents information at some variance from previous reports published in the United States.
Abstract 1771: Role of Tsc2-mTORC1 signaling in homeostasis of intestinal epithelium and its relation to inflammation and cancer
Authors: Takenori Kotani, Jajar Setiawan, Yoji Murata, Yasuyuki Saito, Takashi Matozaki
Journal: Cancer Research (2019)

Abstract Intestinal tumorigenesis driven by mutations in adenomatous polyposis coli gene requires the mammalian target of rapamycin complex 1 (mTORC1) activity, whereas the physiological roles of mTORC1 in the homeostasis of intestinal epithelial cells (IECs) remain virtually unknown. We here generated mice, in which tuberous sclerosis complex 2 (Tsc2), a negative regulator of mTORC1, was specifically ablated in IECs (Tsc2 CKO mice). Tsc2 CKO mice manifested the enhanced proliferative activity of IECs in intestinal crypts as well as the promoted migration of these cells along the crypt-villus axis. In vitro study showed that conditional ablation of Tsc2 in IECs promoted development of intestinal organoids, while mTORC1 inhibitor, rapamycin, diminished this phenotype. Tsc2 CKO mice also manifested the increased apoptotic rate of IECs as well as the increased ectopic Paneth cells, which are one of the major differentiated IECs. In addition, such conditional ablation of Tsc2 resulted in a suppressed expression of Wnt target genes in the colonic epithelium. Finally, we found that Tsc2 CKO mice manifested the increased susceptibility for dextran sulfate sodium (DSS)-induced colitis. Although mTORC1 and Wnt signaling pathways are thought to cooperated to promote oncogenesis in the intestinal epithelium, our results thus suggest that the mTORC1 signaling unexpectedly counter-regulates the Wnt signaling with the maintenance of intestinal homeostasis. Citation Format: Takenori Kotani, Jajar Setiawan, Yoji Murata, Yasuyuki Saito, Takashi Matozaki. Role of Tsc2-mTORC1 signaling in homeostasis of intestinal epithelium and its relation to inflammation and cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1771.
Whole Transcriptome Sequencing Reveals Recurrent NOTCH1 Mutations in Mantle Cell Lymphoma
Authors: Robert Kridel, Barbara Meissner, Sanja Rogic, Merrill Boyle, Adele Telenius, Jay Gunawardana, Chris Cochrane, Arla J Yost, David W Scott, King Tan, Bruce Woolcock, Susana Ben-Neriah, Stephen Opat, Laurie H. Sehn, Joseph M. Connors, Andrew P Weng, Christian Steidl, Randy D. Gascoyne
Journal: Blood (2011)
The Bottom Line
Authors: Naomi Bluestone
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Journals, Academics, and Pandemics
Journal: PLoS Medicine (2010)

Medicine highlight the problem of how to effectively share information in the wake of a rapidly spreading disease, and prompted us to ask the question ''How well are journals doing?''with regard to this important goal.The answer, sadly, seems to be ''not well enough.''Although the potential of the Internet for improving the dissemination of information is now taken for granted, it would seem that the attitudes of those involved in sharing this information have not kept pace with the technology.Accordingly, it is fair to ask whether the flow of information in the face of a crisis is truly enabled by publication in medical journals (even online journals) or whether we need new avenues for rapid data sharing.An article appearing this month in PLoS Medicine by Weijia Xing and colleagues [1] dissected the publication of a subset of epidemiological papers during the severe acute respiratory syndrome (SARS) epidemic of 2003.Based on their findings, it would be hard to conclude that journal publication was a successful mechanism for rapidly sharing information.As the authors note, ''Only 22% of the studies were submitted, 8% accepted, and 7% published during the epidemic.''What were the reasons behind these findings?The authors argue that the lack of standard methods for data collection and manuscript preparation may have played a part.In addition, despite journals' best efforts to speed up times to publication (reflected in shorter publication times compared with control articles on unrelated topics, submitted at the same time), the time to publication was over 200 days for many articles.It's not possible to know whether these delays were compounded by articles being sequentially submitted to a number of different journals before being published.But it is notable that while the 311 SARS articles were published in 137 different journals, the first ten published studies appeared in The Lancet (n = 7) and The New England Journal of Medicine (n = 3).However, the impact factors of journals publishing articles on SARS decreased significantly as time went on.Put another way, it seems that at the beginning of the epidemic, highprofile journals were willing to publish papers on SARS, but their interest waned rapidly.In addition, it is likely that, as with
Abstract 805: Adaptation of mitochondrial organization to aggregation in serous ovarian cancer
Authors: Joseph P. Grieco, Stephanie Edwards, Mitchell Allen, Yao Wang, Justin Perry, Yipei Song, Nathan Swami, David Brown, Eva Schmelz
Journal: Cancer Research (2019)

Abstract During metastasis, ovarian cancer cells exfoliate from the primary tumor and disseminate throughout the peritoneal cavity mostly as aggregates with a higher survival rate and metastatic potential. To determine how the mitochondrial morphology and dynamic expression of fusion and fission-regulating proteins contribute to spheroid survival, in this study we investigated changes in mitochondrial morphology in order to identify phenotypic alterations that are associated with changes in mitochondrial function. We compared monolayers and spheroids of murine and human benign, late-stage, and tumor-initiating cells in hypoxia using fluorescent microscopy and western blot analysis. In addition, we investigated how the mitochondrial membrane potential (Δψm) and ROS production contributed to this phenotype using the InCell analyzer with TMRM and Amplex Red dyes respectively. The data from this study suggest that the morphology and dynamic protein expression are highly altered during tumorigenesis, aggregation, and in hypoxic conditions, indicating a direct correlation of mitochondrial morphology in regulating survival, apoptosis and proliferation. The identification of these molecular events and changes that allow for the survival of metastatic cancer cells in an environment low in oxygen and nutrients may provide specific targets for interventions that would suppress successful metastatic outgrowth of disseminating cells and could potentially be used as a biomarker for treatment efficacy. Citation Format: Joseph P. Grieco, Stephanie Edwards, Mitchell Allen, Yao Wang, Justin Perry, Yipei Song, Nathan Swami, David Brown, Eva Schmelz. Adaptation of mitochondrial organization to aggregation in serous ovarian cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 805.