tbuckley/cabot-search huggingface dataset:
La créatine: Étude physio-pathologique
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Exophthalmic Goitre.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Is Aspirin a Cost-Effective Addition to Colorectal Cancer Screening?
Journal: Annals of Internal Medicine (2001)

Summaries for Patients6 November 2001Is Aspirin a Cost-Effective Addition to Colorectal Cancer Screening?Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-135-9-200111060-00003 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Colorectal cancer is cancer of the colon (large intestine) or rectum. Screening decreases deaths from colorectal cancer by detecting precancerous abnormalities (polyps) and removing them before they become cancer and by detecting cancer in an early stage when it can still be cured with surgery. Screening tests include fecal occult blood testing (FOBT), flexible sigmoidoscopy, and colonoscopy. FOBT uses a chemical reaction to detect blood hidden in stool. Polyps and colorectal cancers can cause blood to leak into the stool, so a positive result on FOBT suggests the ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Aspirin as an Adjunct to Screening for Prevention of Sporadic Colorectal Cancer. A Cost-Effectiveness Analysis.” It is in the 6 November 2001 issue of Annals of Internal Medicine (volume 135, pages 769-781). The authors are U Ladabaum, CL Chopra, G Huang, JM Scheiman, ME Chernew, and AM Fendrick.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAspirin as an Adjunct to Screening for Prevention of Sporadic Colorectal Cancer: A Cost-Effectiveness Analysis Uri Ladabaum , Cathy Lee Chopra , Grace Huang , James M. Scheiman , Michael E. Chernew , and A. Mark Fendrick Metrics 6 November 2001Volume 135, Issue 9Page: I-51KeywordsAspirinCancer screeningColonoscopyColorectal cancerColorectal cancer screeningFlexible sigmoidoscopyHealth economicsHematologic testsRectumSimulation and modeling ePublished: 6 November 2001 Issue Published: 6 November 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Defining HLA-II ligand processing and binding rules with mass spectrometry enhances cancer epitope prediction
Authors: Jennifer G. Abelin, Dewi Harjanto, Matthew Malloy, Prerna Suri, Tyler Colson, Scott P. Goulding, Amanda L. Creech, Lia R. Serrano, Gibran Nasir, Yusuf Nasrullah, Christopher D. McGann, Diana Velez, Ying S. Ting, Asaf Poran, Daniel A. Rothenberg, Sagar Chhangawala, Alex Rubinsteyn, Jeff Hammerbacher, Richard B. Gaynor, Edward F. Fritsch, Joel Greshock, Rob C. Oslund, Dominik Barthelme, Terri A. Addona, Christina M. Arieta, Michael S. Rooney
Journal: Immunity (2021)
Transjugular renal biopsy in the treatment of patients with cirrhosis and renal abnormalities
Authors: P Jouet
Journal: Hepatology (1996)

When renal lesions are suspected in patients with cirrhosis, clotting disorders often preclude percutaneous renal biopsy. This study was undertaken to determine whether transjugular renal biopsy is possible, safe, and useful in such patients. From 1987 to 1994, 70 patients with cirrhosis and clotting disorders underwent transjugular renal biopsies, providing renal tissue in 55. Of these 55 patients, 41 were Child-Pugh class B or C, 35 were alcoholic, serum creatinine levels were ≥ 130 μmol/L in 46, and proteinuria was ≥ 0.5 g/d in 37. Clinically significant complications of transjugular renal biopsy were persistent hematuria in 4 and perirenal hematoma in 4, requiring blood transfusions in 1 and 2 cases, respectively. There were no deaths related to renal biopsy. Renal lesions were identified as glomerular in 41 (74.5%), interstitial in 7, and end-stage in 2 and were absent in 5. Transjugular renal biopsy influenced treatment in 21 patients (38%), including 11 who were proposed for liver transplantation and 4 who had chronic liver rejection. Decisions based on results of transjugular renal biopsy were to perform liver transplantation in 8 and combined renal and liver transplantation in 5, whereas 2 were refused. In 6 other patients, the results of renal biopsy modified the medical regimen. We conclude that transjugular renal biopsy may be a useful procedure in patients with cirrhosis and clotting disorders. This technique does not entail undue risks and may influence treatment decisions, particularly in patients proposed for liver transplantation.
Internet
Authors: Saty Satya-Murti
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pediatric phase I trial and pharmacokinetic (PK) study of dasatinib: A report from the Children’s Oncology Group Phase I Consortium
Authors: R. Aplenc, L. C. Strauss, S. Shusterman, A. M. Ingle, S. Agrawal, J. Sun, J. J. Wright, S. M. Blaney, P. C. Adamson
Journal: Journal of Clinical Oncology (2008)

3591 Background: Dasatinib is an orally-available tyrosine kinase inhibitor with low-nanomolar activity against SRC-family kinases, BCR-ABL, c-KIT, EPHA2, and the PDGFβ receptor. The compound had selective activity against several xenograft tumor types in the Pediatric Preclinical Testing Program. Methods: A phase I study of dasatinib in pediatric patients with refractory solid tumors or imatinib refractory Ph+ leukemia was performed. Dose levels of 50, 65, 85 and 110 mg/m2/dose, administered orally twice daily for 28 d, with courses repeated without interruption, were studied. PK studies were performed with the initial dose. Results: 35 patients (27 solid tumor, 6 CML, 2 ALL), 53% male, with a median (range) age of 11 (2 - 20) yrs, were enrolled. No DLTs were observed in cohorts of 3 pts with solid tumors at the 50, 65 and 85 mg/m2 dose levels. At 110 mg/m2, 2/6 pts experienced DLT: Gr 3 diarrhea (n = 1) and headache (n = 1). In leukemia pts, Gr 3 hypokalemia (n = 1, 50 mg/m2) and diarrhea (n=1, 85 mg/m2) were observed. Dasatinib was otherwise well tolerated in the first course of therapy. DLTs in subsequent courses included pleural effusion (n = 2) and hemangiomatosis with GI hemorrhage (n = 1). There were no CRs or PRs observed in pts with solid tumors; 2 pts had SD for 3 months duration. There were 2 CRs and 3 PRs in response evaluable patients with CML. Dasatinib was rapidly absorbed with a median Tmax of 1 h. The geometric mean (% CV) Cmax and AUC(TAU) were 65.0 (73) ng/mL and 235.8 (26) ng.h/mL at 50 mg/m2 (n=4) and 142.4 (45) ng/mL and 321.9 (41) ng.h/mL at 65 mg/m2 (n=4), respectively. The mean (SD) terminal half-life (t1/2) was 2.2 (0.4) hours. Conclusions: Dasatinib is effective in treatment of pediatric patients with CML. The 85 mg/m2/dose of dasatinib administered twice daily appears to be well tolerated in children, and this dose cohort is being expanded for additional tolerability and PK data. Exposure of dasatinib appears to increase with increasing dose, but the t1/2 in pediatric patients appears shorter compared with the 3–6 hrs observed in adults. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Expert Testimony Other Remuneration Bristol-Myers Squibb Bristol-Myers Squibb
Survival of spermatozoa in a human sperm bank. Effects of long-term storage in liquid nitrogen
Authors: K. D. Smith
Journal: JAMA (1973)

Human semen was frozen and stored in liquid nitrogen for periods of time up to eight years and two months. A total of 1,764 vials containing 1.1 ml of semen from 533 ejaculates provided by 207 donors were frozen. The freezing and thawing process induced a loss of approximately 50% of the original motility. Storage in liquid nitrogen for periods up to 36 months resulted in no further significant loss in mean motility. However, after this time, a progressive significant loss in motility was observed throughout the period of this study. Specimens with initial sperm counts between 40 and 200 million/ml and initial motilities between 60% and 89% appeared to withstand long-term storage best.
LONDON LETTER
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Evidence for the effectiveness of CME. A review of 50 randomized controlled trials
Authors: D. A. Davis
Journal: JAMA (1992)

<h3>Objective.</h3> —To assess the impact of diverse continuing medical education (CME) interventions on physician performance and health care outcomes. <h3>Data Sources.</h3> —Using<i>continuing medical education</i>and related phrases, we performed regular searches of the indexed literature (MEDLINE, Social Science Index, the National Technical Information Service, and Educational Research Information Clearinghouse) from 1975 through 1991. In addition, for these years, we used manual searches, key informants, and requests to authors to locate other indexed articles and the nonindexed literature of adult and continuing professional education. <h3>Study Selection.</h3> —From the resulting database we selected studies that met the following criteria: randomized controlled trials; educational programs, activities, or other interventions; studies that included 50% or more physicians; follow-up assessments of at least 75% of study subjects; and objective assessments of either physician performance or health care outcomes. <h3>Data Extraction.</h3> —Studies were reviewed for data related to physician specialty and setting. Continuing medical education interventions were classified by their mode(s) of activity as being predisposing, enabling, or facilitating. Using the statistical tests supplied by the original investigators, physician performance outcomes and patient outcomes were classified as positive, negative, or inconclusive. <h3>Data Synthesis.</h3> —We located 777 CME studies, of which 50 met all criteria. Thirty-two of these analyzed physician performance; seven evaluated patient outcomes; 11 examined both measures. The majority of the 43 studies of physician performance showed positive results in some important measures of resource utilization, counseling strategies, and preventive medicine. Of the 18 studies of health care outcomes, eight demonstrated positive changes in patients' health care outcomes. <h3>Conclusion.</h3> —Broadly defined CME interventions using practice-enabling or reinforcing strategies consistently improve physician performance and, in some instances, health care outcomes. (<i>JAMA</i>1992;268:1111-1117)
Ten-year follow-up of behavioral, family-based treatment for obese children
Authors: L. H. Epstein
Journal: JAMA (1990)

Using a prospective, randomized, controlled design, we examined the effects of behavioral family-based treatment on percent overweight and growth over 10 years in obese 6- to 12-year-old children. Obese children and their parents were randomized to three groups that were provided similar diet, exercise, and behavior management training but differed in the reinforcement for weight loss and behavior change. The child and parent group reinforced parent and child behavior change and weight loss, the child group reinforced child behavior change and weight loss, and the nonspecific control group reinforced families for attendance. Children in the child and parent group showed significantly greater decreases in percent overweight after 5 and 10 years (-11.2% and -7.5%, respectively) than children in the nonspecific control group ( + 7.9% and + 14.3%, respectively). Children in the child group showed increases in percent overweight after 5 and 10 years ( + 2.7% and +4.5%, respectively) that were midway between those for the child and parent and nonspecific groups and not significantly different from either. At 10 years, child height was related strongly to the height of the parent of the same sex (r=.78): children were 1.8 cm taller than their parents, with no differences in height between groups. (<i>JAMA</i>. 1990;264:2519-2523)
THE BRITISH TRENCH FEVER COMMITTEE REPORT
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PERICOLITIS SINISTRA.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hospitalization for Epilepsy—United States, 1988-1992
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BOOK REVIEWS
Authors: DAVID MURRAY
Journal: JNCI Journal of the National Cancer Institute (1991)

BOOK REVIEWS Get access An Introduction to Radiobiology . A. H.W. Nias . Chichester,England : John Wiley & Sons , 1990 , 360 pp. $35.95. DAVID MURRAY DAVID MURRAY Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 14, 17 July 1991, Page 1028, https://doi.org/10.1093/jnci/83.14.1028 Published: 17 July 1991
Laparoscopic Cholecystectomy
Authors: Bruce M. Wolfe
Journal: JAMA (1991)

<h3>In Reply.</h3> —Jako and Rozsos describe an alternative limited-access technique to laparoscopic cholecystectomy in which the need for carbon dioxide insufflation is replaced by retraction on the anterior abdominal wall. This technique may have merit as an adjunct to laparoscopic cholecystectomy in cases in which the pneumoperitoneum cannot safely be established or fails for technical reasons. Potential disadvantages to Jako and Rozsos' technique include the need for a larger upper abdominal incision and limitations to the extent to which complete inspection of the peritoneal cavity can be accomplished. It is doubtful that Jako and Rozsos' procedure is more economical than laparoscopic cholecystectomy, as specialized instruments and optical systems are required. The insufflator is the least expensive of the components needed for laparoscopic cholecystectomy. Disposable trocars and clip appliers as well as lasers are not needed for safe accomplishment of laparoscopic cholecystectomy.<sup>1</sup> Schonberg has concluded, based on the DATTA report,