tbuckley/cabot-search huggingface dataset:
Colorectal Disease
Authors: R. Dale Liechty
Journal: JAMA (1983)

For a century and a half, St Mark's Hospital has been a leading world center in the management of diseases of the hind gut. In this anthology of colorectal and anal disease, 49 staff members, friends, and associates of St Mark's have pooled their knowledge, which originated in a lecture series for those preparing for the fellowship examination of the Royal College of Surgeons. The result is most pleasing: a concise, practical course in colorectal and anal disease. Beginning with investigative procedures and physiology (normal and disordered function of the large bowel), this book continues with "Principles of Surgical Management" and "Management of Complications." The authors devote the first half of the text to basic considerations, the last to diseases of the large bowel and anus—an excellent blend of theory and practice. Take, for example, the lowly hemorrhoid. The St Mark's group has discarded the old concept, "from the times
Frontiers in surgery. A perspective
Authors: J A Pierce, B E Sobel
Journal: JAMA (1991)

TWO BRILLIANT advances in surgery summarized in this issue ofThe Journal<sup>1,2</sup>elucidate fundamental phenomena in the pathophysiology of end-stage pulmonary disease and atrial fibrillation. <h3>Lung Transplantation</h3> The positive experience with lung transplantation summarized by Trulock and associates<sup>1</sup>is a consequence of a remarkable sequence of developments in immunology and surgery. In their series of consecutive patients with end-stage pulmonary disease, the survival rate is impressive, and the functional recovery is dramatic, with improved expiratory airflow and reduction to normal pulmonary artery pressures in those operated on for pulmonary hypertension. A majority of the patients returned to rather active lives following transplantation, in great contrast to their pretransplantation status.
University News.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Massive hepatic apoptosis associated with TGF-β1 activation after Fas ligand treatment of IGF binding protein-1–deficient mice
Authors: Julia I. Leu, Mary Ann S. Crissey, Rebecca Taub
Journal: Journal of Clinical Investigation (2003)

Acute liver failure caused by viral hepatitis or toxic damage involves both apoptotic and necrotic pathways.IGF binding protein-1 (IGFBP-1), a hepatocyte-derived secreted protein, is required for normal liver regeneration.To determine whether IGFBP-1 could prevent liver injury that entails direct stimulation of hepatocyte apoptosis, IGFBP-1 -/-mice, IGFBP-1 +/+ mice, and mice pretreated with Ab's against IGFBP-1 were treated with a normally sublethal dose of Fas agonist.IGFBP-1 deficiency was associated with massive hepatocyte apoptosis and caspase activation within 3 hours of Fas agonist treatment, which could be corrected by pretreatment with IGFBP-1.IGFBP-1-deficient livers had enhanced signaling via the integrin receptor at early times (0.5 to 1 hour) after Fas agonist treatment accompanied by elevated activated matrix metalloproteinase-9 (MMP-9), a known target of fibronectin signaling and activator of TGF-β.Within 3 hours of Fas agonist treatment, elevated expression of active TGF-β1, a hepatocyte apoptogen, was observed in IGFBP-1-deficient livers that correlated with the appearance of the apoptotic process.Both MMP-9 and TGF-β1 expression were suppressed by IGFBP-1 treatment, supporting their role in the apoptotic process.IGFBP-1 -/-mice also displayed increased injury in a toxic hepatic injury model caused by CCl 4 .These findings indicate that IGFBP-1 functions as a critical hepatic survival factor in the liver by reducing the level of proapoptotic signals.
Roles of Long-term Treatment Ward and Community Based Integrated Care Ward in the Terminal Care of Lung Cancer
Authors: Kan Kato, Naoki Iwashita, Gou Matumoto, Maya Izawa, Eitetu Jyo, Toshihiko Okabe, Kageaki Watanabe, Yuusuke Ookuma, Yukio Hosomi
Journal: Annals of Oncology (2016)
Reply
Authors: Scott W. Canna, Charlotte Girard, Louise Malle, Adriana de Jesus, Neil Romberg, Judith Kelsen, Lea F. Surrey, Pierre Russo, Andrew Sleight, Eduardo Schiffrin, Cem Gabay, Raphaela Goldbach-Mansky, Edward M. Behrens
Journal: Journal of Allergy and Clinical Immunology (2017)
STATISTICS OF THE STATE BOARD EXAMINATIONS
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prevalence of significant hepatic fibrosis using magnetic resonance elastography in a health check-up clinic population
Authors: Kyung A Kang, Dae Won Jun, Joo Hyun Sohn, Jihyun An, Eileen Yoon, Jaeyoon Jeong, Sang Bong Ahn, Hyo Young Lee, Jinhwa Park, Yong Kyun Cho, Bo-Kyeong Kang, Mi Mi Kim
Journal: Journal of Hepatology (2020)
The Mineral Content of the Lung in Chronic Berylliosis
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Association of step count with PROMIS health-related quality of life measures in children and adolescents with persistent asthma
Authors: Allison Burbank, Michelle Hernandez, Nicole Lucas, Courtney Mann, Li Lin, Wanda Phipatanakul, Jessica Brown, Misha Sims, Sally Ivins, Antonia Bennett, Amparito Cunningham, Michelle Maciag, Nicole Akar-Ghibril, Bryce Reeve
Journal: Journal of Allergy and Clinical Immunology (2021)
Local Government and Sanitary Department
Journal: BMJ (1873)

Although several subjects for examination are in each instance given, .Iis is rather to afford the option of one or more to the candidates than .cinduce them to present a superficial knowledge of several.Indeed, it is expressly stated by some of the colleges that good clear knowledge cf ore or two subjeets will be more esteemed than a general knowledge of several.Candidates, especially those who are not members of the 'University, will, in most instances, be required to show a fair know- i'dge of classics and mathematics, such, for example, as would enable tLem to pass the previous examination.There is no restriction on the ground of religious denomination in the case of these or of any of the scholar-slhips or exhibitions in the colleges or in the University.Fur- h;er infor-mation may be obtained from the tutors of the respective colleges.It may be added that Trinity College will give a fellowship for Natural Science once, at least, in three years: and that most of
Cigarette smoking cessation and extracranial carotid atherosclerosis
Authors: G. S. Tell
Journal: JAMA (1989)

Using B-mode ultrasonography, cigarette smoking was found to be a strong, independent risk factor for extracranial carotid atherosclerosis in 1692 black and white men and women admitted for diagnostic evaluation of the carotid arteries. We found that the difference in mean plaque thickness was smaller between past smokers and nonsmokers than between current smokers and nonsmokers, suggesting that the rate of progression of carotid atherosclerosis may be slower in people who quit smoking compared with people who continue to smoke. (<i>JAMA</i>1989;261:1178-1180)
ON THE ORIGIN AND TREATMENT OF CHRONIC DISEASES OF THE SKIN
Authors: T. Hunt
Journal: BMJ (1855)

OOKKUNIOATI.-s-t6, 1, Te geneal comcidence of a dimnsd dishage with inerease of hearing.This will appear by the notes taken March the 3rd and 28th, April the 29th, May the 13th and 27th, affording evidence of the influence of mecha- uical impediments in the production of deafness.Too much ,tresi however, must not be laid on this explanation;
Eccrine sweat glands associate with the human hair follicle within a defined compartment of dermal white adipose tissue
Authors: E. Poblet, F. Jimenez, E. Escario-Travesedo, J.A. Hardman, I. Hernández-Hernández, J.L. Agudo-Mena, J.J. Cabrera-Galvan, C. Nicu, R. Paus
Journal: British Journal of Dermatology (2018)

It has always been assumed that sweat glands are distributed throughout the skin unconnected with hair follicles (hair “roots”) and their associated sebaceous (or “grease”) glands, which, together with other specialised glands and the muscles that make hairs stand up, are known as pilosebaceous units. Sweat glands and pilosebaceous units, in other words, have always been considered separate structures, with sweat glands opening on to the skin surface between hairs rather than alongside them. Sweat glands on the palms of the hands and the soles of the feet develop differently and were not considered in this study. Using a number of techniques, including looking down the microscope at sections of hair follicles taken from the scalp during hair transplants, and at manual and computer‐assisted 3D reconstructions of sections of scalp skin, this study from Spain and Manchester, UK, suggests that in hair‐bearing areas the deepest part of the sweat gland, a coiled structure, is in fact located very close to the deepest part of the pilosebaceous unit, sitting right by the sheath of the hair follicle, below the sebaceous gland and the point where the hair muscle attaches. Moreover, these structures sit together within cone‐shaped projections of fat that reach upwards into the lowest layer of the skin, the thick reticular dermis, from the fat underneath. The authors speculate that sweat glands, pilosebaceous units and this particular fatty tissue (collectively the “adnexal skin unit”) may interact in certain skin diseases, during wound healing and with drug treatments.
THE OVERCROWDING OF THE MEDICAL PROFESSION
Authors: W. Gordon
Journal: BMJ (1903)

Overcrowding in the Medical Profession.The reports of the American Consuls at Chemnitz and Frankfort on overcrowding of the medical profession in Germany will b3 read with interest by every medical man in the United Kingdom.Mr. Monaghan, writing from Chemnitz, says that the overcrowding ia the medical profession in Germany is yearly growing worse, yet more and more
The weakening of the Oslerian tradition. The changing emphasis in departments of medicine
Authors: W. Regelson
Journal: JAMA (1978)

SIR William Osler, in his speech on "Teacher and Student" in 1892, said "an academic system without the personal influence of teachers upon pupils, is an arctic winter; it will create an ice bound, petrified, cast-iron university, and nothing else."<sup>1</sup> A generation or two ago, the professor of medicine was molded on the rational and humanistic Oslerian tradition. The essential characteristics of the teacher of medicine were a concern for students and patients and a broad knowledge of clinical medicine. Concern for the patient was a prime responsibility, on a one-to-one basis in a bond of ego and morality that placed the internist as the first arbiter between dissolution and death. The patient was an individual, and the interaction could transcend readily into concerns for economic, family, and emotional factors. The student and house staff were equally involved as people fascinated by the professor's knowledge and performance. The peer
Pyrolysis Products of PCBs
Authors: Jaakko Paasivirta, Rainer Herzschuh, Tarmo Humppi, Erkki Kantolahti, Juha Knuutinen, Mirja Lahtipera, Risto Laitinen, Juhani Salovaara, Juhani Tarhanen, Liisa Virkki
Journal: Environmental Health Perspectives (1985)

Model compound studies which were previously done for impurities and environmental residues of chlorophenols and for wastes of chlorination processes were extended to the impurities and pyrolysis products of polychlorinated biphenyls (PCBs). Model compounds were commercial products or synthesized and their structures proven by spectroscopic methods. These models were used as analytical reference substances in GC/ECD and GC/MS studies of the pyrolyzed PCB samples. In addition to previously known neutral components like polychlorinated dibenzofurans (PCDFs), chlorophenolic substances, especially polychlorophenols (PCPs) and polychlorinated biphenylols (PCB-OHs) were observed as major pyrolysis products of PCBs. Capacitor fires are suggested to produce in many cases chlorophenols which are major toxic hazards to people.
Creatine kinase-BB: A marker of liver sinusoidal damage in ischemia-reperfusion
Authors: M Vaubourdolle
Journal: Hepatology (1993)

Cell damage within the sinusoidal lining of human liver grafts during transplantation is an early event that is critical in ischemia-reperfusion injury and probably plays a key role in primary liver dysfunction after transplantation. No simple biochemical marker for sinusoidal injury is currently available. Because creatine kinase activity has been described in heart endothelial cells, we hypothesized that release of this enzyme might serve as an index of sinusoidal injury. To test this hypothesis, we used several in vivo and in vitro experimental models. Occlusion of the rat hepatic pedicle in situ for 60 min (normothermic ischemia) induced a significant increase in serum creatine kinase levels relative to those in laparotomized controls (2,530 ± 530 vs. 389 ± 64 IU/L, mean ± SEM; p < 0.005). In the isolated perfused rat liver, 60-min ischemia induced early (≤ 3 min) creatine kinase and AST release (0.87 ± 0.14 vs. 0.08 ± 0.01 IU/min/gm liver, respectively). A similar phenomenon was observed after 24-hr or 48-hr hypothermic conservation in University of Wisconsin solution. Electrophoretic analysis and immunoinhibition studies showed that creatine kinase activity comprised creatine kinase-BB (≈ 50%) and mitochondrial creatine kinase. Trypan blue infusion showed a loss of viability in sinusoidal cells, whereas hepatocytes were relatively spared. Finally, murine sinusoidal cells were isolated, cultured and then lysed by a freeze-thaw cycle and sonication. Creatine kinase activity was found in endothelial cells (creatine kinase-BB), Kupffer cells (creatine kinase-BB) and Ito cells (creatine kinase-MM). Creatine kinase-BB was not found in hepatocytes, but mitochondrial creatine kinase was detected. These results indicate that liver ischemia-reperfusion injury induces a release of creatine kinase-BB from sinusoidal cells and of mitochondrial creatine kinase from hepatocytes, suggesting that creatine kinase-BB activity could provide a simple index of cell damage within the sinusoidal lining. (HEPATOLOGY 1993;17:423–428.)
Women's Health
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Smoking and health
Journal: JAMA (1980)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Single-dose treatment of urinary tract infections
Journal: JAMA (1979)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dupilumab 临床试验中的结膜炎
Authors: B. Akinlade, E. Guttman‐Yassky, M. Bruin‐Weller, E.L. Simpson, A. Blauvelt, M.J. Cork, E. Prens, P. Asbell, E. Akpek, J. Corren, C. Bachert, I. Hirano, J. Weyne, A. Korotzer, Z. Chen, T. Hultsch, X. Zhu, J.D. Davis, L. Mannent, J.D. Hamilton, A. Teper, H. Staudinger, E. Rizova, G. Pirozzi, N.M.H. Graham, B. Shumel, M. Ardeleanu, A. Wollenberg
Journal: British Journal of Dermatology (2019)

结膜炎是一种导致眼睛变红、瘙痒和渗出的常见疾病。它在特应性皮炎(也称为湿疹)和其他过敏性疾病(包括哮喘)的患者中常见。除了过敏,感染、化学品、刺激物和其他疾病也可引起结膜炎。Dupilumab 是一种处方药,在美国批准用于不能通过局部外用(外用到皮肤)处方药控制或不能局部外用药物的≥ 12 岁中重度 AD 患者,在其他国家批准用于通过现有治疗无法控制的 AD 成人,和用于通过当前用药无法控制的≥12 岁中重度哮喘患者的维持治疗。Dupilumab 可阻滞导致这些过敏性疾病的特定物质的活性。在大部分 AD 研究中,接受dupilumab治疗患者中的结膜炎发生率多于安慰剂(模拟药物)组。为了研究这一作用,作者们评估了在 AD、哮喘、慢性鼻窦炎伴鼻息肉(CRSwNP) 和嗜酸性粒细胞性食管炎(EoE) 中开展的 11 项 dupilumab 研究中的结膜炎的发生率、风险因素、严重程度和结局。在 6 项 AD 研究的 5 项中,dupilumab治疗患者较安慰剂治疗患者更容易发生结膜炎。没有确认因感染导致的结膜炎,其性质似乎也不是过敏性的。进入这些研究时 AD 较严重患者或之前曾患过结膜炎的患者更容易患结膜炎。在哮喘和 CRSwNP 研究中,dupilumab 和安慰剂组的结膜炎发生率均低于 AD 研究,且dupilumab 和安慰剂组相似。在 EoE 研究中,没有人患有结膜炎。在所有研究中,结膜炎大部分为轻中度;大部分病例在治疗期间恢复。需要进一步研究 dupilumab治疗患者中的结膜炎原因。