tbuckley/cabot-search huggingface dataset:
Neonatal herpes simplex virus infection in King County, Washington. Increasing incidence and epidemiologic correlates
Authors: J. Sullivan-Bolyai
Journal: JAMA (1983)

The incidence of neonatal herpes simplex virus (HSV) infection in King County, Washington, has increased progressively from a rate of 2.6 per 100,000 live births to King County residents during the years 1966 through 1969 to 4.8, 7.4, and 11.9 cases per 100,000 live births for the years 1970 through 1973, 1974 through 1977, and 1978 through 1981, respectively. Detailed interviews of the parents of newborns with neonatal HSV-2 infection revealed clinically symptomatic genital herpes in the mother or father in 65% of the parents and serological and/or cultural evidence of HSV-2 infection in the mother in the other 35% of cases. Clinically symptomatic first episodes of genital herpes during pregnancy occurred in four of the mothers who were delivered of newborns with neonatal HSV-2 infection; two of the mothers were symptomatic at the time of birth. The other 16 interviewed mothers who delivered newborns with neonatal HSV-2 infection all had serological and/or cultural evidence of past HSV-2 infection but were asymptomatic at term. All six newborns with neonatal HSV-1 infection acquired the disease from nongenital sources, and two newborns seemed to have acquired the disease from nonmaternal sources. These data indicate that detailed interviews of the parents are often useful in increasing the clinician's index of suspicion for neonatal HSV infection. The increased prevalence of genital HSV infection in the United States seems to be associated with a concomitant increase in neonatal HSV infection. (<i>JAMA</i>1983;250:3059-3062)
A proposal to develop meaningful labeling for cigarettes
Authors: J. E. Henningfield
Journal: JAMA (1994)

SINCE the 1980s, tobacco researchers have understood that the advertised nicotine-yield ratings of cigarettes do not accurately predict nicotine intake by individual cigarette smokers.<sup>1-5</sup>Cigarette smokers obtain an average of 1 mg of nicotine from each cigarette they smoke, whether the nicotine yield is 0.1 mg or 2 mg.<sup>4,6</sup>However, smokers with whom we have spoken believe that their "light" or "ultralight" cigarettes are providing them with substantially lower doses of nicotine and other constituents of tobacco smoke. These smokers seem to assume that nicotine-yield ratings are equivalent to the content ratings provided on food products, and they are often distressed to learn that nicotine-yield ratings are not indicative of how much nicotine they can obtain. We propose a new strategy for testing and labeling cigarettes that would provide consumers with improved information about how much nicotine they will absorb by smoking a particular brand of cigarette. Our
Chronic Osteomelitis
Authors: Patrick J. Kelly
Journal: JAMA (1970)

A study was made of chronic osteomyelitis in 75 patients, 40 of whom were treated by saucerization followed by closed irrigation and suction (group 1), and 35 patients who also were treated by saucerization but, instead of closed irrigation and suction thereafter, the bone defect was filled with either autogenous bone or muscle implants or simply closed secondarily (group 2). A comparison of these two groups (years 1962 through 1966) and a group of 112 patients (years 1953 through 1961) who could have been treated with closed irrigation and suction indicates that the highest rate of success was observed in the 40 patients treated by closed irrigation and suction after saucerization.
Cancer of the ovary.
Journal: BMJ (1979)

Cancer of the ovaryCancer of the ovary is now the fourth most common cause of death from cancer in British women and the most common fatal gynaecological malignancy.As deaths from carcinoma of the uterine cervix have fallen in the past 20 years those from ovarian carcinoma have steadily risen from 2702 in 1958 to 3486 in 1974.The pattern is the same in the United States, where there is a death from carcinoma of the ovary every 50 minutes.World statistics suggest that in women of European or American origin the incidence of ovarian carcinoma is three to four times higher in Asian and African women.Since, how- ever, in countries where the disease is relatively common (Israel, Denmark, the United States, England) the maximum incidence is in women aged 55-65 years, these racial differences may be due in part to variations in life expectancy.That would
Choroidal Tubercles: A Clue to Hematogenous Tuberculosis.
Authors: D. J. Massaro
Journal: Annals of Internal Medicine (1963)

s1 April 1963Choroidal Tubercles: A Clue to Hematogenous Tuberculosis.D. J. Massaro, M.D., S. Katz, M.D., F.A.C.P., M. Sachs, M.D.D. J. Massaro, M.D.Search for more papers by this author, S. Katz, M.D., F.A.C.P.Search for more papers by this author, M. Sachs, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-4-735_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptUnfortunately, in miliary and other forms of hematogenous tuberculosis, the diagnosis is frequently dependent upon roentgen and other laboratory data. When chest film is clear, as it may be early in the course of the disease, this diagnosis is often not considered, and crucial biopsies and culture procedures are not performed or their performance is delayed, to the patients' detriment. Furthermore, when a diffuse miliary lung lesion appears in a setting consistent with miliary tuberculosis, compatible physical findings would be helpful to make the diagnosis more secure. We have found the choroidal tubercle, which has received wide recognition in the... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: D. J. Massaro, M.D.; S. Katz, M.D., F.A.C.P.; M. Sachs, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byClinical analysis of pregnancy complicated with miliary tuberculosis 1 April 1963Volume 58, Issue 4 Page: 735-736 Keywords Biopsy Lesions Lungs Miliary tuberculosis Research laboratories Thorax ePublished: 1 December 2008 Issue Published: 1 April 1963 PDF downloadLoading ...
Anna, Gravid
Authors: Donna Mae Brown
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ABSTRACTS
Journal: Journal of Clinical Investigation (1973)

Proinsulin:insulin ratios in serum are higher than in pancreatic islets.This ratio is highest in the fasting state and at late times after stimuli to insulin secretion.Differences in peripheral metabolism of endogenous insulin (ti = 4.8 min) and proinsulin (ti = 17.2 min) are partly responsible for these findings.To investigate whether differential pancreatic secretion or variable hepatic clearance of the polypeptides may also contribute, we have calculated posthepatic deliver rates (PHDR) of insulin and proinsulin after oral glucose.Specimens were obtained at 15-to 30-min intervals during 5-h oral GTT's in four healthy subjects.Proinsulin and insulin were separated by gel filtration and measured by radioimmunoassay against human proinsulin and insulin standards.Using a disappearance constant derived for endogenous proinsulin and insulin, PHDR were calculated assuming constant delivery during each time interval.The highest insulin level occurred at 30 min (2.63±0.80ng/ml), while proinsulin peaked at 105 min (1.04±0.45ng/ml).Basal insulin PHDR was 2844 pg/ml per min, and increased to 408±124 pg/ml per min at 15-30 min.Thereafter a gradual decline to 20±4 pg/ml per min occurred by 5 h.Proinsulin PHDR rose from 7±1 pg/ml per min in the basal state to plateau between 36 and 46 pg/ml per min at 15-105 min and returned to vasal values by 5 h.The fasting ratio of insulin PHDR:proinsulin PHDR was 4.5± 0.8, rose to 12.042.4 in the 0-15 min interval, and returned to basal levels by 3 hr.These observations can be explained either by preferential beta cell release of insulin in the early poststimulatory period or relatively decreased hepatic insulin extraction when insulin secretion is maximal.The significant correlation observed between the PHDR ratio of the two polypeptides and insulin PHDR supports the latter interpretation.
Schaefer's Course of Practical Histology.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Induction of T-helper cell response to hepatitis B core antigen in chronic hepatitis B: A major factor in activation of the host immune response to the hepatitis B virus
Authors: George Marinos, Francesco Torre, Shilpa Chokshi, Munther Hussain, Berwin E. Clarke, David J. Rowlands, Adrian L. W. F. Eddleston, Nikolai V. Naoumov, Roger Williams
Journal: Hepatology (1995)

The T helper (Th) cell response to hepatitis B core antigen (HBcAg) was analyzed in 76 chronic hepatitis B virus (HBV) carriers with varying degrees of hepatic inflammation and HBV replication. Fifty-five patients had active viral replication, 28 with minimal histological changes and normal alanine transaminase (ALT) and 27 with active hepatic inflammation and elevated ALT. The remaining 21 chronic hepatitis B surface antigen (HBsAg) carriers had undetectable HBV replication, minimal histological activity, and normal ALT. In addition, 34 chronic HBV carriers were studied prospectively during treatment with α-interferon. The HBcAg-specific Th cell response was evaluated by a proliferative assay using 3 H-thymidine uptake and γ-interferon production by peripheral blood mononuclear cells. The proliferative response and γ-interferon production of patients with active hepatic inflammation were significantly higher than in patients with minimal histological changes and in controls. In the longitudinal analysis during α-interferon treatment, 22 of 34 patients sustained an ALT flare accompanied by a parallel, significant Th cell response, which preceded or coincided with the ALT flare. The elevation in the Th cell response and the ALT flare were followed by a significant rise in the serum immunoglobulin (Ig) M anti-HBc index. Ten of twenty-two patients with an enhanced Th cell response and an ALT flare seroconverted after α-interferon treatment. The Th cell activity in the 10 responders rapidly subsided after hepatitis B e antigen (HBeAg) to anti-HBe seroconversion, whereas in the 12 nonresponders it remained elevated. This study demonstrates that patients with chronic hepatitis B (CAHB) have a detectable and a significant Th cell response to HBcAg, which is likely to be involved in augmenting the immune-mediated hepatocellular damage and in the activation of HBV-specific humoral immune reaction. Thus, loss of Th cell nonresponsiveness to HBcAg is an important factor in enhancing the effector immune responses to HBV in chronic hepatitis B. (Hepatology 1995; 22:1040-1049.).
Letter: Rabies.
Authors: I McIntyre
Journal: BMJ (1975)

visit Should the first level be above 7 mnnIl/l (270 mg/100 ml) or any subse- quent value exceed this figure, then the pill should normally not be commenced or con- tinued.But even where there are no facilities for such analyses the well-trained presmiber, whether medical or non-medical, and the fully informed user should be able to balance the dangers of the pill against its benefits in each individual case.
Short-term prophylaxis with cefotaxime for prostatic surgery
Authors: T B Hargreave
Journal: BMJ (1982)

A randomised controlled trial of a new cephalosporin, cefotaxime, was carried out in men undergoing trans- urethral resection of the prostate.The purpose of the trial was to determine whether 48-hour prophylaxis with this new broad-spectrum, non-nephrotoxic cephalo- sporin would reduce postoperative bacteriuria and post- operative complications.The treated patients fared significantly better than the non-treated patients in having fewer febrile episodes, fewer episodes of tachycardia, a lower incidence of appreciable bacteriuria
Alcohol Poisoning Deaths Hit Middle-Aged Men Hardest
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Semilateral decubitus breast examination
Authors: A. D. Heymann
Journal: JAMA (1980)

<h3>In Reply.—</h3> I agree entirely with Dr Portnoi that many patients currently in hospital levels of care could be served better by placement in nonhospital (extended) care levels. This is a premise central to the development of the VA's Multilevel Care System, in which its hospital and nonhospital (extended) levels of care—including skilled and intermediate nursing homes, hospital-based home care programs, personal care home programs, and domiciliaries—are linked, through carefully defined placement criteria and procedures, in a way that facilitates patient flow in both directions. Such close linkage is dictated by the needs of an aging population, which not only will require more extended care services but also will experience more acute care episodes—a fact not always appreciated by health care planners. One point of clarification: the VA's criteria for placing patients in the five hospital levels of care were not fully enumerated inThe Journalarticle, which mentioned, for
Just Words
Authors: Alexander Gode
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Withdrawing life support in Canada and the United States
Authors: L. A. Whittaker
Journal: JAMA (1995)

<h3>To the Editor.</h3> —I read with interest the article by Dr Cook and colleagues<sup>1</sup>describing factors that influence Canadian health care workers in their decision to withdraw life support from critically ill patients. There are innumerable medical and ethical considerations involved in end-of-life decisions. The authors effectively illustrate that several factors unrelated to patient characteristics influence Canadian health care workers in their decisions, leading to "extreme variability" in how these situations are handled in Canada. The situation is a little different in the United States, however, and the authors do not allude to the differences in making end-of-life decisions that exist between the two countries. An important influence on who actually makes the decision is the allocation of health care resources. Canada has a nationalized system of health care in which limited resources (including intensive care unit [ICU] beds and life support equipment) are allocated on the basis of
The cost of disposables
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Commentaire du travail de Mukai S et al., pp. 47
Journal: Endoscopy (2014)

Shuntaro Mukai, Takao Itoi, Todd H. Baron, Atsushi Sofuni, Fumihide Itokawa, Toshio Kurihara, Takayoshi Tsuchiya, Kentaro Ishii, Shujiro Tsuji, Nobuhito Ikeuchi, Reina Tanaka, Junko Umeda, Ryosuke Tonozuka, Mitsuyoshi Honjo, Takuji Gotoda, Fuminori Moriyasu, Ichiro Yasuda. Endoscopic ultrasound-guided placement of plastic vs. biflanged metal stents for therapy of walled-off necrosis: a retrospective single-center series.
HIV infection in Thailand: the use of condoms
Authors: M. VanLandingham
Journal: JAMA (1994)

<h3>In Reply.</h3> —Dr VanLandingham is critical of the measure of condom use given in our study of HIV infections in young men in northern Thailand. We used self-reported condom use with last CSW instead of usual condom use in order to improve the recall of the subjects. However, we asked participants several questions about their use of condoms, including frequency of usual condom use with CSWs and other sexual partners. Each of these condom-use variables was examined for its association with HIV-1 prevalence in univariate and multivariate analysis. In univariate analysis, we found either no significant association between reported condom use and HIV-1 prevalence or an increased prevalence associated with more frequent reported condom use with CSWs. For example, among men who reported usually using condoms with CSWs, the HIV prevalence was 18.5%, compared with 13.8% in those reporting some condom use but "less than half the time" and 9.4%
Impotence in medical clinic outpatients
Authors: M. F. Slag
Journal: JAMA (1983)

One thousand one hundred eighty men in a medical outpatient clinic were screened as to the presence of impotence. Four hundred one men (34%) were impotent, and of those, 188 (47%) chose to be examined for their problem. After a comprehensive evaluation the following diagnoses were obtained: medication effect, 25%; psychogenic, 14%; neurological, 7%; urologic, 6%; primary hypogonadism, 10%; secondary hypogonadism, 9%; diabetes mellitus, 9%; hypothyroidism, 5%; hyperthyroidism, 1%; hyperprolactinemia, 4%; miscellaneous, 4%; and unknown causes, 7%. The mean age of the impotent patients was 59.4 years, and the prevalence of alcoholism was 7%. Luteinizing hormone, follicle-stimulating hormone, testosterone, thyroxine, triiodothyronine (T<sub>3</sub>), T<sub>3</sub>resin uptake, and prolactin studies were necessary to diagnose individual cases. We conclude that erectile dysfunction is a common and often overlooked problem in middle-aged men followed in a medical clinic. (<i>JAMA</i>1983;249:1736-1740)