tbuckley/cabot-search huggingface dataset:
STUDIES OF THE GANGLION CELLS AND THE CHANGES THAT OCCUR IN THEM IN GENERAL DISEASES AND OTHER CONDITIONS.
Journal: JAMA (1898)

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Medicolegal
Journal: JAMA (1910)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
JAMA Psychiatry
Authors: Phil Fontanarosa, Annette Flanagin, Brenda Gregoline, Tracy Frey, Kevin Brown, Amanda Ehrhardt, Iris Lo, M Newman, Suzanne Walker, Connie Manno, Sara Billings, Timothy Gray, Paul Ruich, Sam Wilder, Catherine Alden, Stephanie Beckmeyer, Jane Calayag, Jan Clavey, Mary Coerver-Connolly, Paula Glitman, Laura King, Regina Lilly, Thressa Smith, Donna Thordsen, Carolina Woods, Aggie Zarkadas, Wanda Assistant, Larry Bryant, Jacob Kendall-Taylor, Monica Mungle, Fanny Brown, Anna Bukowski, Lee Calibeo, Lenette Gardner-Gullens, Tosca Hall, Erin Kato, Rachell Lozano, Caroline Sietmann, Angelia Waltower, Michael Berkwits, Eric Butkus, Michelle Kurzynski, Emily Ling, Jesse Mcquarters, Daniel Morrow, Daniella Peting, Reuben Rios, Carrie Butt, Mary Ferkaluk, Karen Bucher, Andy Rekito, Nick Reback, David Song, Deputy Livingston, Thomas Cole, Marla Hall, Deanna Willis, Yolanda Davis, Joseph Thornton, Deanna Bellandi, Jim Periodical, Thomas Easley, Brian Shields, Karen Adams-Taylor, Paul Gee, Monica Smith, Jeff Ery, J Bonistalli, Kathy Russell, Mirna Monal, Stacey Mchugh, Marketing Thornbury, Tricia Classifi, Anna Manager, Thalia Moss, Sade Deramus-Townsend, Tony Ralenkotter, Saskia Bolore, Gretchen Linder, Brian Mccartney, Christine Hearne, Natasha Staff, David Baum, Morgan Osgood, Ron Thomas, Rick Bell, Elizabeth Solaro, Sara Zimmerman, Geoff Rey, Fergus Clare, Lindsay Dawson, Ellen Gibson, Mustafa Ishaq, Sam Ismail, Peter Litton, Craig Mccaff Rey, Michael Mcgraw, Jon Perkins, Daniel Pickhardt, Romando Rossini, Sarah Subramanian, Stacy Business, Analyst Sirisha, Alluri Staff, Millette Jackson-Bates, Tom Miller, Karl Elvin, Nancy Essex, Jaye Mize, Sean O'donnell, Sue Managers, David Antos, Anthony Bautista, Chris Borden, Debbie Camp, Jennifer Carney, Lydia Cruz, Scott Curl, Diane Darnell, Nanette Diaz, Jordynn Farrar, Allison Hughes, Colleen Kelly, Chris Meyer, Annemarie Neff, J Neff, Sean Ohlson, Phil O'leary, Bill Pedone, Susan Price, Binita Shah, Erin Spencer, Denise Steinhauser, Joe Advertising, Production Services, Ahmed Avendano, Kim Boler, Rhonda Brown, Fin Carter, Michael Deegan, Daniel Degroot, Euwanaha Joiner-Smith, Joshua Lane, Cindy Rendlen, Ellen Yoshihara, Circulation Services, Julie Burton, Ronna Hewitt, Mary Sieck, Geneine Someren, Jamaal Vargas, New Media, Gail Barrett, Regina Brownlee, Amanda Camino, Brenda Chandler-Grayer, Emily Dunn, Amy Evers, Maleeka Holden, Teri Hutchison, Dan Knowles, Joshua Lampinen, Natalie Marsh, Nathan Mitre, Patricia Panek, Marla Seidell, La Son, Diggs Sledge, Julian Graphics, Joe Amft, James Collver, Maria Duda, Fred Furtner, Carolyn Hall, Maria Kowalkowski, Carla Benton, Carol Farrell, Daniel James, Judith Literskis, Teresa Omiotek, Michael Ryder, James Madara, Bernard Hengesbaugh, Sara Dibari, Martin Paulus, Helen Simpson, New York, John Torous, Helena Chmura Kraemer, Palo Alto, Howard Bauchner
Journal: JAMA Psychiatry (2019)
Abstract 4985: TLR agonists for anticancer immunotherapy
Authors: Wenqiu Zhang, Hyunjoon Kim, Vidhi Khanna, David M. Ferguson, Thomas Griffith, Jayanth Panyam
Journal: Cancer Research (2019)

Abstract Introduction: Toll-like receptors (TLRs) are important pattern recognition receptors through which innate immune cells recognize invasive microorganisms. The immunostimulatory property of TLR agonists allows for activation of dendritic cells (DCs) and enables their use as anticancer vaccine adjuvants. Because TLR 7 and 8 can be activated by synthetic small molecules, they are of particular interest as a target in vaccine adjuvant discovery. However, a key drawback of these synthetic small molecules is that they also induce immunosuppressive cytokines, resulting in immunosuppression. Methods: We have previously developed a suite of highly substituted imidazoquinolines, which potently activate TLR 7 and/or 8. In this study, we tested some selected TLR7, TLR8 and TLR7/8 dual agonists for their ability to activate DCs without inducing immune suppressive cytokines. Murine bone marrow-derived dendritic cells (BMDCs) were generated from C57BL/6 mice. BMDCs were treated with one of seven TLR agonists for 72 hrs. Cells were collected and stained for flow cytometry analysis, and the culture supernatants were examined for secretion of pro-inflammatory cytokines, IL-12p70 and IFN-γ, and an immunosuppressive cytokine, IL-10, by ELISA. We also investigated activation of T cells by these agonists. Human peripheral blood mononuclear cells (hPBMCs) from healthy donors were incubated with one of seven TLR agonists overnight and cells were analyzed by flow cytometry for the expression of T cell activation marker CD69 and production of IFN-γ. Results: All the TLR agonists investigated activated BMDCs, as evidenced by the upregulation of costimulatory markers CD40, CD80 and CD86 on DCs. In addition, all the agonists examined induced the secretion of IL-12p70 and IFN-γ. TLR 8 agonists showed the least induction of IL-10 secretion. All the TLR agonists activated both CD4 and CD8 T cells. TLR 8 agonists induced higher production of IFN-γ in both type of T cells than other candidates. Conclusion: Both TLR 8 and TLR 7/8 agonists activated BMDCs and stimulated strong pro-inflammatory cytokine production. However, TLR8 activation was associated with less immunosuppression. These results suggest that these new imidazoquinoline esters are promising candidates for use as anti-cancer vaccine adjuvants. Citation Format: Wenqiu Zhang, Hyunjoon Kim, Vidhi Khanna, David M. Ferguson, Thomas Griffith, Jayanth Panyam. TLR agonists for anticancer immunotherapy [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4985.
Endobronchial nocardiosis
Authors: FE Casty, M Wencel
Journal: European Respiratory Journal (1994)

The presentation of a Nocardia infection is quite variable. We report a case of nocardiosis presenting as endobronchial obstruction with postobstructive pneumonia and atelectasis, in a patient with a low index of suspicion for bronchogenic carcinoma. Our report emphasizes the importance of considering the diagnosis of endobronchial nocardiosis in patients with endobronchial obstruction and a low index of suspicion for carcinoma, as well as those with a high index of suspicion, but with repeatedly negative biopsies.
International Comments
Journal: JAMA (1976)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Validation of Transgenic Mice Carrying the Human Prototype c-Ha-ras Gene as a Bioassay Model for Rapid Carcinogenicity Testing
Authors: Satoshi Yamamoto, Koji Urano, Haruko Koizumi, Shigeharu Wakana, Kyoji Hioki, Kunitoshi Mitsumori, Yuji Kurokawa, Yuzo Hayashi, Tatsuji Nomura
Journal: Environmental Health Perspectives (1998)
PRESENT STATUS OF "INSULIN"
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cecil Coggins
Authors: Harry L. Arnold
Journal: JAMA (1980)

<h3>To the Editor.—</h3> Cecil Henry Coggins, MD, could hardly have had to fight off hordes of<i>Aedes aegypti</i>mosquitoes as he lay on the ground at night in Hawaii in 1942, as related by Eugene G. Laforet, MD (243:1653, 1980).<i>Aedes aegypti</i>is our day mosquito, and they were all asleep. What he fought off was<i>Culex quinquefasciatus</i>, our night mosquito, and it would not have transmitted any yellow fever, of course. Others had been concerned, as he was, about this hazard. I was visiting the Army's chief of epidemiology and geographic medicine in Washington, DC, on Dec 9, 1941: GEN James Stevens Simmons, an army medical school classmate of my father's. The rumors had just been published that Japanese parachutists had descended on Hawaii. GEN Simmons wondered aloud whether they might have been bringing in cages of yellow fever infected mosquitoes. However, nothing came of it; indeed, to the
Continuing medical education
Authors: D. K. Wentz
Journal: JAMA (1990)

As the field of continuing medical education (CME) looked forward to the decade of the 1990s, 1989 held a number of pivotal events. This report summarizes some of those events and updates ongoing CME and American Medical Association/Physician's Recognition Award (AMA/PRA) activities that occurred between June 1989 and June 1990. <h3>COOPERATION IN CME</h3> The informal working group formed on October 8, 1988, to explore potential areas of cooperation and collaboration in CME met on October 26, 1989, in Chicago, Ill. The same "charter" organizations participated (the Alliance for Continuing Medical Education [ACME], the Accreditation Council for Continuing Medical Education [ACCME], the Association of American Medical Colleges, the Association for Hospital Medical Education, the AMA, the Council of Medical Specialty Societies, the Society of Medical College Directors of Continuing Medical Education, the Southern Medical Association, and state medical societies). Topics discussed included the Second Congress on Continuing Medical Education, the change of publisher
Gastric Ulcers in Swine
Authors: Dale E. Fuller
Journal: JAMA (1968)

Swine are afflicted with gastric ulcers which resemble those found in man. Because of the similarities, we believe that swine can provide a useful model (both research and teaching) for studying peptic ulcers of the stomach in man. Several factors may play a part in the etiology of these ulcers in swine, and some of these have parallels in ulcer disease in humans.
1119 EFFECT OF MESENCHYMAL STEM CELL ON HEPATIC FIBROSIS IN THIOACETAMIDE-INDUCED CIRRHOTIC RAT MODEL
Authors: M.Y. Kim, S.K. Baik, M.Y. Cho, S.O. Kwon, D.J. Kim, K.T. Suk, G.J. Cheon, Y.D. Kim, D.H. Choi
Journal: Journal of Hepatology (2013)
Abstract 3499: Extracellular Loop (Domain I, S5-S6) of α1D L-type Ca Channel is an Antigenic Site in Autoimmune Associated Congenital Heart Block
Authors: Eddy Karnabi, Yongxia Qu, Raj Wadgaonkar, Salvatore Mancarella, Yunkun Yue, Mohamed Chahine, Robert Clancy, Jill P Buyon, Mohamed Boutjdir
Journal: Circulation (2008)

Congenital heart block (CHB) is an autoimmune disease associated with autoantibodies against intracellular ribonucleoproteins SSB/La and SSA/Ro. The hallmark of CHB is complete atrioventricular block. We have established that anti-SSA/Ro -SSB/La autoantibodies inhibit L-type α 1D Ca current, I Ca-L and cross-react with the α 1D Ca channel protein. This study aims at identifying the possible binding sites on α 1D protein for autoantibodies from sera of mothers with CHB children. GST fusion proteins of the extracellular regions between the transmembrane segments (S5-S6) of each of the four α 1D Ca channel protein domains I–IV were prepared and tested for reactivity with sera from mothers with CHB children and controls using ELISA. Sera from 118 mothers with CHB children and 28 control healthy sera were used in this study. Seventeen of 118 (14.4%) maternal CHB sera reacted with the extracellular loop of Domain I S5-S6 region (E1). In contrast, 2 of 28 (7%) healthy control sera reacted with the E1 loop. Preincubation of E1 loop with the positive sera decreased the O.D. reading of the positive sera establishing the specificity of the response. Electrophysiological characterization of the ELISA positive sera demonstrated inhibition (44.1%) of the α 1D I Ca-L expressed in tsA201 cells. The inhibition was abolished when the sera were pre-incubated with E1 extracellular loop fusion protein. The results identified the extracellular loop of domain I S5-S6 of L-type Ca channel α 1D subunit as a target for autoantibodies from mothers with CHB children. This novel finding provides insights into the development of therapeutic peptides that could bind to the pathogenic antibodies.
Clinical and Biologic Effects Of The Angiopoietin 1/2 Neutralizing Peptibody, Trebananib (AMG 386), In Acute Myeloid Leukemia Patients
Authors: Eunice S. Wang, Gerald Fetterly, William Brady, Wei Tan, Jessica Greene, Allison Gaudy, Carlos E Vigil, Jason H. Mendler, Michael W. Becker, Kristen O'Dwyer, Jane L. Liesveld, Meir Wetzler
Journal: Blood (2013)
Abstract P137: Effect of Obesity &amp; T2DM on Cardiac Strain in Youth
Authors: Jessica E Haley, Zhiqian Gao, Philip Khoury, Stephanie N Stewart, Nicolas L Madsen, Thomas R Kimball, Lawrence M Dolan, Elaine M Urbina
Journal: Circulation (2017)

Introduction: Heart failure is a complication of long standing T2DM. Advanced echo measures can identify early sub-clinical systolic dysfunction in adults with T2DM. We hypothesized that subtle systolic dysfunction was present in young diabetics. Methods: Longitudinal strain was measured in 151 subjects with T2DM matched by age, race and sex to a lean (L=146), and non-diabetic (proven by OGTT) obese (O=162) control (23.0 ± 4.0 years, 35% male, 63% African American). Anthropometrics, BP, HR, fasting lipids, glucose and CRP and echocardiograms for LVM, shortening fraction (SF), global longitudinal 4-chamber strain (GLS) and strain rate in systole (GLSR) were obtained. ANOVA was performed to compare differences among groups for CV risk factors and strain measures and ANCOVA to determine if presence of T2DM remained an independent predictor of strain after correction for risk factors (full model=age, sex, race, presence of T2DM, BMI, SBP, DBP, HR and lab values). Results: CV risk factors worsened and there was a graded decline in GLS from L to O to T2DM subjects. GLSR was less negative and LVM/ht 2.7 was higher in O &amp; T as compared to L (all p &lt; 0.05). There was no difference in SF among groups. Presence of T2DM was an independent determinant of GLS and GLSR adjusted for most CV risk factors but lost significance when BMI was added to the model. GLS = -21.6 -age*0.088 - male*1.8 + 0.12*BMI + 0.045*DBP + 0.058*HR - 0.023*HDL (R 2 = 0.38, p&lt;0.0001); GLSR = -1.20 -male*0.093 + WHR*0.48 + DBP*0.0029 (R 2 = 0.23, p&lt;0.0001). Conclusion: Early in the course of T2D in youth, obesity has a greater deleterious effect on systolic function than T2DM. Treatment of obesity in youth is necessary for prevention of future heart failure.
Erratum: Vol. 53, No. 1
Journal: JAMA (2004)

whether for pre-or postexposure prophylaxis) must complete that vaccination series on time, using nonrecalled vaccine.Information about human rabies prevention based on current recommendations of the Advisory Committee on Immunization Practices (ACIP) is available at http://www .cdc.gov/mmwr/preview/mmwrhtml /00056176.htm.
Childbirth. An Outline of Its Essential Features and the Art of Its Management.
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Maternofetal Passage of Leukocytes and Platelets in Man
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Human Health Risk Assessment: A Case Study Involving Heavy Metal Soil Contamination after the Flooding of the River Meuse during the Winter of 1993-1994
Authors: Harma J. Albering, Sandra M. van Leusen, Edwin J. C. Moonen, Jurian A. Hoogewerff, Jos C. S. Kleinjans
Journal: Environmental Health Perspectives (1999)

At the end of December 1993 and also at the end of January 1995, the river Meuse, one of the major rivers in Europe, flooded and river banks were inundated. We investigated the possible health risks of exposure to heavy metal concentrations in river bank soils resulting from the flooding of the river Meuse at the end of 1993. Soil and deposit samples and corresponding aerable and fodder crops were collected and analyzed for heavy metals. Although the soils of the floodplain of the river Meuse appeared severely polluted mainly by Cd and Zn, the heavy metal concentrations in the crops grown on these soils were within background ranges. Incidentally, the legal standard for Cd as endorsed by the Commodities Act was exceeded in wheat crops. The main exposure pathways for the general population were through the consumption of food crops grown on the river banks and through the direct ingestion of contaminated soils. For estimating potential human exposure in relation to soil pollution, we used a multiple pathway exposure model. For estimating the actual risk, we determined metal contents of vegetables grown in six experimental gardens. From this study, it can be concluded that there is a potential health risk for the river bank inhabitants as a consequence of Pb and Cd contaminations of the floodplain soils of the river Meuse, which are frequently inundated (averaged flooding frequency once every 2 years).