tbuckley/cabot-search huggingface dataset:
Expanded phase I study of vorinostat (VOR) in combination with capecitabine (CAP) in patients (pts) with advanced solid tumors
Authors: C. Townsley, A. M. Oza, P. Tang, L. L. Siu, G. R. Pond, P. Sarveswaran, S. Webster, J. A. Zwiebel, E. X. Chen
Journal: Journal of Clinical Oncology (2008)

11096 Background: VOR (suberoylanilide hydroxamic acid; SAHA) is a small molecule inhibitor of histone deacetylase (HDAC) that binds directly to the enzyme’s active site in the presence of a zinc ion. Aberrant HDAC activity has been implicated in a variety of cancers. The combination of 5-fluorouracil and VOR is synergistic in preclinical tumor models. Methods: This expanded phase I study evaluated safety, tolerability, and the recommended phase II dose (RPTD) of VOR and CAP in pts with advanced solid tumors. VOR was administered orally daily while CAP was administered orally bid on days 1–14 of a 21 d cycle. Results: Three dose levels were evaluated (VOR (mg/d) /CAP (mg/bid)): 300/750, 300/1000 and 400/1000. Twenty-eight pts have been treated: 7M/21F, median age 59 (range 36- 73), ECOG 0:1:2 = 12:15:1, prior therapy 1:2:3 or more = 7:8:13. Pts had colorectal cancer (n=9), nasopharyngeal (n=3) and various other tumors. A total of 137 cycles have been administered, with median = 4 (range 1–15). One dose limiting toxicity (DLT) (grade 3 diarrhea) occurred in 6 patients at dose level 1. No DLT were observed at dose level 2, and 2 DLTs (grade 3 fatigue and grade 3 nausea/vomiting) occurred at dose level 3. RPTD was determined to be VOR 300 mg/d and CAP 1000 mg/bid. This dose level was then expanded to include a total of 14 patients. The most frequent adverse events experienced of any grade were anemia (20 [71%] patients across 90 [66%] cycles), fatigue (16 [57%] patients across 87 [64%] cycles) and hyperglycemia (23 [82%] patients across 63 [46%] cycles). Grade 3 adverse events experienced by 3 or more patients were HFS (5 patients), fatigue and lymphopenia (4 patients each), diarrhea and vomiting (3 patients each). One pt died on study from ventricular fibrillation due to sotalol and hypocalcemia from pre-existing hypoparathyroidism. No other grade 4 or 5 adverse events occurred. One patient with breast cancer had a PR in cycle 2 followed by an unconfirmed CR in cycle 4, and three patients with various tumor types had a PR. In addition, disease stabilization was seen in 18 patients. Conclusions: VOR and CAP are well tolerated, and this combination is active in several tumor types. Further evaluations of VOR and CAP are warranted. No significant financial relationships to disclose.
Antibody–Drug Conjugate Kills Neuroblastoma Cells
Journal: Cancer Discovery (2019)

Researchers have developed an antibody-drug conjugate with the potential to treat neuroblastoma. The agent targets ALK, which is found on neuroblastoma cells but not healthy cells, delivering a drug that causes DNA cross-links. Researchers have found that the antibody-drug conjugate kills ALK-expressing cells in vitro and increases survival in mouse models of neuroblastoma.
Normal Hematopoiesis and Neurofibromin-Deficient Myeloproliferative Disease Require Erk
Authors: Karl Staser, Yi Zeng, Su-jung Park, Steven D. Rhodes, Yongzheng He, Matthew A. Shew, Jeff Gehlhausen, Donna Cerabona, Shi Chen, Zejin Sun, Grzegorz Nalepa, Feng-chun Yang, D. Wade Clapp
Journal: Blood (2012)
Discharge from Psychiatric Hospitals
Authors: M. Quinn
Journal: BMJ (1972)

<h3>Background</h3> Evidence suggests reducing consumption of sugar-sweetened beverages is important to reducing weight gain and chronic disease risk. Indonesia’s large population is a growing market for sugar-sweetened beverages. Taxation to reduce consumption is of interest, but considered fiscally regressive. Little is known about differential effects between income groups in low-income countries. <h3>Methods</h3> This modelling study uses a proportional multistate life table to model reduced daily energy intake following a $0.30 per litre tax on sugar-sweetened beverages and subsequent shifts in Body Mass Index (BMI) distribution for income groups in Indonesia. Energy balance equations calculate reduced BMI. Reduced incidence of type 2 diabetes mellitus, ischaemic heart disease and stroke is determined from the relative risk of the BMI shift and subsequent health-adjusted life years gained calculated. <h3>Results</h3> The tax’s effect was greater for higher income quintiles than lower. Energy intake reduced most in higher income quintiles. Cases of overweight and obesity for women decreased by approximately 15 000 in the lowest income quintile, but 417 000 for the highest. For men, this was 12 000 and 415 000. Over 25 years, 63 000 cases of diabetes were averted in the lowest quintile and 1 487 000 in the highest. Similar magnitudes were observed for stroke and ischaemic heart disease. Tax paid over 25 years was $0.5 billion for the lowest income quintile and $15.1 billion for the highest. <h3>Conclusion</h3> Sugar-sweetened beverage taxation can help to reduce the number of overweight and obese, and prevent over a million cases of diabetes in Indonesia. Higher income groups would benefit more than lower income groups. The tax would raise $920 million in the first year and $27.3 billion over 25 years.
DISSEMINATION OF BACTERIA FROM THE MOUTH DURING SPEAKING, COUGHING, AND OTHERWISE.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A CASE OF CIKCULAB INSANITY STUDIED FROM CLINICAL, DIFFERENTIAL AND FORENSIC STANDPOINTS.
Authors: RICHARD DEWEY
Journal: JAMA (1904)

<h3>FIFTH MANIC-DEPEESSIVE CYCLE.</h3> In October, 1895, a petition<i>de lunatico</i>was again filed, and at the hearing it was testified that he had shown an immoral photograph to a young girl of twelve. This hearing was interrupted by a scuffle and altercation in court between X. and a witness, and by his calling the judge a "cheap skate." He was committed to jail for contempt. Immediately after he made three applications for a habeas corpus before as many judges, two of which were denied. He was released on the third and immediately rearrested, and when later the hearing on the question of insanity came up before a jury, the latter brought in a verdict of sanity, and he was never declared insane or committed to an institution for the insane again; not because he did not continue to exhibit an unbalanced mind, but apparently because all attempts to control
Recollected
Authors: Donna Pucciani
Journal: JAMA (2013)

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MEDICAL ENGLISH AS SHE IS WROTE
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Bundle of Information
Journal: JAMA (1971)

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Medical School Deans
Authors: Ransom J. Arthur
Journal: JAMA (1971)

<h3>To the Editor.—</h3> If one grants that there are such entities as human beings who possess bodies and psyches (and perhaps even souls), and if one further grants that these humans can develop infirmities of the body or mind, then it should not be surprising if the possessors of these malfunctions seek out other individuals who might put things right. These other individuals, whom we call healers, of necessity operate within a certain conceptual framework. From the beginning of recorded time both in the Occident and in the Orient, these healers have utilized, however imperfectly, disciplines which we might call anatomy, physiology, pathology, and pharmacology to bring about the hoped for therapeutic results in the afflicted individual. Whether the healer was in Africa, ancient Greece, or modern Europe and North America, he still had to initially learn certain concepts in order to pursue his medical practice. Perhaps Martians or some
A REMARKABLE SURVIVAL OF SEVERE INJURIES.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cancer Risk Assessment of 1,3-Butadiene
Authors: Ila L. Cote, Steven P. Bayard
Journal: Environmental Health Perspectives (1990)

This paper discusses the Environmental Protection Agency's (EPA) risk assessment of 1,3-butadiene. The assessment focuses on estimation of increased cancer risk to populations living near industrial sources of 1,3-butadiene emissions rather than occupationally exposed populations. Incremental cancer risk estimates based on extrapolation from laboratory animal data are presented. Pharmacokinetic data published since the EPA's 1985 assessment are incorporated, which somewhat alters the earlier assessment of cancer risk. Characterization of emission sources, estimates of ambient air concentrations, and population exposure are also discussed. The estimate presented in this paper of excess cancer cases resulting from point source exposure to 1,3-butadiene is decreased to approximately 40% of the estimate published in 1985 from 6.4 in 10 to 2.5 chances in 10 for a lifetime exposure to 1 ppm. The current estimate is no more than eight additional cancer incidences in the general population. Increased risk to the most exposed individuals is not anticipated to be greater than 1 in 10. This reduction in the risk estimate is due to a change in the estimate of 1,3-butadiene potency (i.e., incremental unit risk estimate) based on incorporation of new pharmacokinetic data.
THE PROPAGATION OF YELLOW FEVER.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The European Union provides funding to strengthen the protection against zoonoses and animal diseases
Authors: Collective Eurosurveillance editorial team
Journal: Eurosurveillance (2011)

Preview this article: The European Union provides funding to strengthen the protection against zoonoses and animal diseases, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/16/46/art20019-en-1.gif
THE EDINBURGH TRADITION AND CLINICAL INSTRUCTION.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction
Journal: Circulation (2010)

was an error on line 8 of the Methods and Results section of the Abstract.In the published article, the authors referred to "impaired insulin tolerance."This should have read "impaired fasting glucose."The corrected text should appear as follows: "Among the metabolic syndrome components, obesity (age-and sex-adjusted hazard ratio [HR], 1.64), elevated blood pressure (HR, 1.69), low high-density lipoprotein cholesterol (HR, 1.52), and impaired fasting glucose (HR, 1.44 [NCEP-ATP III] and 1.35 [AHA/NHLBI]) showed an increased risk for AF."Corrections have also been made to Tables 2 and4, where the authors used "impaired glucose tolerance."This has been replaced with "impaired fasting glucose.
SURGICAL TREATMENT OF EXTENSIVE BASAL CELL CARCINOMA
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Kallmann's syndrome associated with atrial septal defect
Authors: C. Dimitrovski
Journal: JAMA (1982)

THE EXISTENCE of hypogonadism with anosmia was first described in an autopsy case in 1856 by Maestre de San Juan.<sup>1</sup>In 1944, Kallmann et al<sup>2</sup>suggested sex-linked inheritance of hypogonadotropic hypogonadism with anosmia and noted occurrence of harelip, cleft palate, and craniofacial asymmetry. Since then, other clinical cases associated with various skeletal, ophthalmic, urogenital, and cardiovascular abnormalities have been reported.<sup>3-5</sup> This article reports an association of Kallmann's syndrome with atrial septal defect (ASD)-type ostium secundum. <h3>Report of a Case</h3> A 22-year-old male student was admitted to our clinic because of great concern about his small penis and inadequate masculinization. He had never shaved or ejaculated. There was a history of lifelong insensitivity to common odors but no family history of hypogonadism, sterility, anosmia, or cardiovascular disorder. Physical examination showed a eunuchoidal man with some increased adipose tissue over the abdomen and hips. His height was 173 cm
Abstract B04: Targeting CREB-CBP transcription factor complex using small molecule inhibitors with multifunctional anticancer mechanisms.
Authors: Jong Woo Lee, Hee Sun Park, Sin-aye Park, Roy S. Herbst, Jaseok Peter Koo
Journal: Clinical Cancer Research (2014)

Abstract This abstract is being presented as a short talk in the scientific program. A full abstract is printed in the Proffered Abstracts section (PR03) of the Conference Proceedings. Citation Format: Jong Woo Lee, Hee Sun Park, Sin-aye Park, Roy S. Herbst, Jaseok Peter Koo. Targeting CREB-CBP transcription factor complex using small molecule inhibitors with multifunctional anticancer mechanisms. [abstract]. In: Proceedings of the AACR-IASLC Joint Conference on Molecular Origins of Lung Cancer; 2014 Jan 6-9; San Diego, CA. Philadelphia (PA): AACR; Clin Cancer Res 2014;20(2Suppl):Abstract nr B04.
Hypoglycemia and the Postprandial Syndrome
Authors: F. John Service
Journal: New England Journal of Medicine (1989)

Although low blood glucose concentrations were known to occur in patients with various diseases in the 19th century, a clinical syndrome of hypoglycemia was not recognized until the early 1920s, when symptoms similar to those of insulin-induced hypoglycemia were observed in persons without diabetes. A new disease called hyperinsulinism and characterized by "hunger, weakness and the anxiety neuroses," was postulated.1 The subsequent identification of a pancreatic islet-cell tumor in a patient who had such symptoms concomitantly with low blood glucose concentrations confirmed the existence of hyperinsulinism.2 Whipple3 recommended that the sine qua non for the diagnosis of hyperinsulinism be the . . .
Effect of fructose on alcohol concentrations in the blood in man
Authors: L. M. Lowenstein
Journal: JAMA (1970)

Fructose has previously been found to be the most effective experimental compound in increasing the metabolism of alcohol (ethanol). In this clinical study, fructose, glucose, or saline infusions were administered intravenously to subjects who simultaneously drank 300 ml of bourbon. Fructose infusions resulted in a lowering of the alcohol levels in the blood by 43% compared to the values obtained during saline solution infusions. Glucose infusions were ineffective. The lowering of the alcohol levels by fructose may occur because the dissociation of the alcohol dehydrogenase-NADH complex is accelerated by intermediary metabolites of fructose.