tbuckley/cabot-search huggingface dataset:
CEREALS AND EXPERIMENTAL RICKETS
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pneumatosis cystoides esophagi. Case report supporting theory of submucosal spread
Authors: B. Vanasin
Journal: JAMA (1971)

A patient with lower esophageal stricture developed pneumatosis cystoides esophagi after many years. Proximal to the stricture air had penetrated the submucosa into the deep muscle layers, suggesting that air entering through a mucosal defect proximal to the stricture was driven into deeper layers by high pressures resulting from partial obstruction. Distal to the stricture air cysts were limited to the submucosa suggesting that air had dissected caudally by peristalsis through loose submucosal tissue to the stomach and proximal small intestine.
Targeted intraoperative radiotherapy tumour bed boost during breast conserving surgery after neoadjuvant chemotherapy.
Authors: Hans-Christian Kolberg, Gyoergy Loevey, Leyla Akpolat-Basci, Miltiades Stephanou, Peter A. Fasching, Michael Untch, Cornelia Liedtke, Max Bulsara, Jayant S. Vaidya
Journal: Journal of Clinical Oncology (2016)

e12528 Background: The safety and efficacy of targeted intraoperative radiotherapy (TARGIT – IORT) as a tumour bed boost after breast conserving surgery for women with early breast cancer is well established. We present its use in patients undergoing breast conservation following neoadjuvant therapy, a higher risk group. Methods: This non-randomised cohort study involved 116 consecutive patients who had neoadjuvant chemotherapy followed by breast conserving therapy. We compared the outcomes of 61 patients who received their tumour bed boost with TARGIT IORT using Intrabeam at the time of lumpectomy (20Gy to surface of tumour bed in a single dose) after it was introduced, vs. 55 patients treated in the previous 13 months with external beam radiotherapy (EBRT) boost of 10Gy in 5 fractions. All patients received whole breast external beam radiotherapy (25 fractions 50Gy). Local recurrence free survival, disease free survival, distant disease free survival, breast-cancer mortality, non-breast-cancer mortality and overall mortality were compared. Results: Median follow up was 49 months. The differences in local recurrence free survival, disease free survival and breast cancer survival were not statistically significant. The 5-year Kaplan-Meier estimate of overall survival was significantly better by 15% with TARGIT: TARGIT 2 events 96.7%(95%CI 87.5 – 99.2), EBRT 9 events 81.7% (95%CI 67.6 – 90.1), HR 0.19 (0.04 – 0.87), log rank p = 0.016, mainly due to a reduction of 10.1% in non-breast-cancer mortality: TARGIT 0 events 0%, EBRT 89.9% (77.3 – 95.7), HR (not calculable), log rank p = 0.015. There was also a 17.5% improvement in distant disease free survival: TARGIT 7 events 88.5% (77.4 - 94.4), EBRT 12 events, 71.0% (52.0 – 83.6), HR 0.53(0.20-1.36), log rank p = 0.18. Conclusions: TARGIT-IORT during lumpectomy after neoadjuvant chemotherapy is safe and may lead to superior overall survival. These data support the much debated idea that TARGIT-IORT may have beneficial systemic effects, a hypothesis that is being tested in the TARGIT-B(oost) international randomised trial.
American Journal of Psychiatry, Hanover, NH
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Jiang S, Alberich-Jorda M, Zagozdzon R, Parmar K, Fu Y, Mauch P, Banu N, Makriyannis A, Tenen DG, Avraham S, Groopman JE, Avraham HK. Cannabinoid receptor 2 and its agonists mediate hematopoiesis and hematopoietic stem and progenitor cell mobilization. Blood. 2011;117(3):827–838.
Journal: Blood (2011)
Estrogen Therapy for Prostate Carcinoma
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Alcohol Use
Authors: David P. Dooley, Thomas M. Brown
Journal: Annals of Internal Medicine (2016)

Letters6 September 2016Alcohol UseDavid P. Dooley, MD and Thomas M. Brown, MDDavid P. Dooley, MDFrom University of Texas Health Science Center at San Antonio and Audie L. Murphy Veterans Affairs Medical Center, San Antonio, Texas.Search for more papers by this author and Thomas M. Brown, MDFrom University of Texas Health Science Center at San Antonio and Audie L. Murphy Veterans Affairs Medical Center, San Antonio, Texas.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L16-0108 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We are encouraged by the attention that Edelman and Fiellin give to the features of alcohol use (1). Their discussion was not meant to be comprehensive, but it might be useful to mention the occasional occurrence of thiamine deficiency (with frank beriberi), ascorbic acid deficiency (with frank scurvy), or both in seemingly well-nourished alcoholics who present with congestive heart failure, edema, easy bruising, or poor wound healing. We have frequently observed both of these conditions in our medium-sized hospital (2, 3). Awareness is important because both require more than the traditional “banana bag”—that is, large doses of ...References1. Edelman EJ, Fiellin DA. In the Clinic. Alcohol use. Ann Intern Med. 2016;164:ITC1-16. [PMID: 26747315]. doi:10.7326/AITC201601050 LinkGoogle Scholar2. Veerapaneni K, Brown TM, Dooley DP. Combined deficiencies of vitamins B1 and C in well-nourished patients. Prim Care Companion CNS Disord. 2014;16. [PMID: 25664204] doi:10.4088/PCC.14br01649 CrossrefMedlineGoogle Scholar3. Brown TM. Neuropsychiatric scurvy. Psychosomatics. 2015;56:12-20. [PMID: 25619670] doi:10.1016/j.psym.2014.05.010 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From University of Texas Health Science Center at San Antonio and Audie L. Murphy Veterans Affairs Medical Center, San Antonio, Texas.Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L16-0108. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAlcohol Use E. Jennifer Edelman and David A. Fiellin Alcohol Use Alain Braillon and David B. Menkes Alcohol Use E. Jennifer Edelman and David A. Fiellin Metrics 6 September 2016Volume 165, Issue 5Page: 379KeywordsAlcoholicsAlcoholsBeriberiConflicts of interestDisclosureEdemaHeart failureThiamineWound healing ePublished: 6 September 2016 Issue Published: 6 September 2016 Copyright & PermissionsCopyright © 2016 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Internalizing communication
Authors: Gerard O'Brien, Jon Opie
Journal: Behavioral and Brain Sciences (2002)

Carruthers presents evidence concerning the cross-modular integration of information in human subjects which appears to support the “cognitive conception of language.” According to this conception, language is not just a means of communication, but also a representational medium of thought. However, Carruthers overlooks the possibility that language, in both its communicative and cognitive roles, is a nonrepresentational system of conventional signals – that words are not a medium we think in, but a tool we think with. The evidence he cites is equivocal when it comes to choosing between the cognitive conception and this radical communicative conception of language.
Help the Underprivileged
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
News From the American Heart Association
Journal: Circulation (2007)

Understanding the Complexity of Trans Fatty Acid Reduction in the American Diet: American Heart Association Trans Fat Conference 2006.Read about the current status and future implications of reducing trans fatty acids without increasing saturated fats in the food supply, while functionality and consumer acceptance of packaged, processed, and prepared foods are maintained.Product code 71-0326.• AHA Guideline: Evidence-Based Guidelines for Cardiovascular Disease Prevention in Women: 2007 Update.This update provides the most current clinical recommendations for the prevention of cardiovascular disease in women Ն20 years of age and is based on a systematic search of the highest-quality science, interpreted by experts in the fields of cardiology, epidemiology, family medicine, gynecology, internal medicine, neurology, nursing, public health, statistics, and surgery.These guidelines also cover the primary and secondary prevention of chronic atherosclerotic vascular diseases.Product code 71-0401.• AHA Guideline: Prevention of Infective Endocarditis.This guideline updates the recommendations for the prevention of infective endocarditis that were last published in 1997.Product code 71-0407.• AHA Policy Statement: Nonfinancial Incentives for Quality.Four principles were crafted to guide the structure and metrics used in pay-for-quality programs, and they identified at least 6 areas that required additional research to serve as criteria that should be considered when designing and evaluating pay-for-quality programs.Product code 71-0387.
Guy's Hospital has seen changes in 163 years, now initiates 'model management' of its own
Authors: J. F. Henahan
Journal: JAMA (1989)

ON FEBRUARY 1, the Conservative Thatcher government in Great Britain proposed a series of major changes in the country's National Health Service that are more drastic and far-reaching than anything that has occurred since "socialized medicine" was introduced by the then Labour government 40 years ago. The changes (detailed in the accompanying article) will have a major impact on how medicine will be practiced in the United Kingdom in the future and will inevitably influence how physicians will treat their patients and the extent to which patients will be able to get good medical care. (Activation of the new plan awaits approval by the British Parliament, but considering that Prime Minister Margaret Thatcher's Conservative party has a majority of about 100, it will almost certainly be voted into law. However, even if that happened immediately, it is estimated that it would take about 3 years before it was fully implemented.)
Perforation of a Duodenal Diverticulum by Peroral Suction Biopsy
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Anesthesiology
Authors: John S. Hattox
Journal: JAMA (1981)

Steady scientific progress continues to be made on broad fronts in the specialty of anesthesiology. There are several that deserve highlighting and are presented here, not necessarily in order of their importance. <h3>Invasive Monitoring</h3> Invasive monitoring continues to receive substantial attention in the literature and at postgraduate symposia. The difficult question is when to monitor and, more specifically, when to monitor pulmonary capillary wedge pressures. Guidelines for use of balloon-tipped catheters were first suggested by Swan and Ganz<sup>1</sup>in 1974. However, the topic continues to be debated heavily. One is struck with the wide spectrum of positions taken on this subject. Swan<sup>2</sup>revealed his own bias by declaring central venous pressure (CVP) monitoring to be outmoded. Mangano,<sup>3</sup>in admirable fashion, has recently made an effort to compare the CVP with the pulmonary capillary wedge pressure under varying conditions in a group of patients undergoing cardiopulmonary bypass. Simultaneous
Is the Heat Labile Variant of Methylene Tetrahydrofolate Reductase (MTHFR-HL) Associated with Elevated Plasma Total Homocysteine (tHcy) and Premature Coronary Artery Disease (CAD)?
Authors: Paul N. Hopkins, Rima Rozen, Steven C. Hunt, Lily L. Wu
Journal: Circulation (2001)

P18 Patients with premature CAD (onset ≤55 in males, ≤65 in females) generally have higher tHcy while MTHFR-HL has been inconsistently associated with CAD. To address this issue we determined MTHFR genotype (HL vs wild type = WT), and measured tHcy, plasma folate, vitamins B12 and B6, and standard risk factors in 224 (74% male, mean age 56.0 ± 6.0) patients with premature, familial CAD (cases) and in 146 controls (56% male, mean age 48.7 ± 6.5). As expected, tHcy was significantly higher in cases (p &lt; 0.0001) and in subjects with low folate (&lt;16 nmol/L, p &lt;0.0001). Furthermore, there was a significant interaction between case status, MTHFR-HL homozygosity (HL/HL), and low folate as shown in the figure (shown are least-square means ± 95% CI; p = 0.0072 for interaction term; “other” refers to WT/WT and WT/HL genotypes). However, the frequency of MTHFR-HL homozygosity was not different in cases (10.71%) versus controls (10.96%), nor was there an excess of risk associated with having both HL/HL and low folate though numbers were small (4.9% of cases versus 4.1% of controls). Thus, the MTHFR-HL variant may contribute to high tHcy in premature CAD cases with low folate status, but a direct effect of MTHFR-HL on CAD risk appears to be unlikely, at least in populations with sufficient folate intake. Figure 1.
Biological terrorism. Preparing to meet the threat
Authors: J. D. Simon
Journal: JAMA (1997)

The threat of terrorists using biological warfare agents has received increased attention in recent years. Despite the hope that, with the right mix of policies, security measures, and intelligence gathering, a major biological warfare terrorist attack can be prevented, the history of conventional terrorism indicates otherwise. The greatestpayoff in combating biological terrorism lies in focusing on how best to respond to a terrorist attack. The medical and emergency service communities will play the most important role in that process. Ensuring that they are trained to recognize the symptoms of diseases caused by biological warfare agents and have Critical Incident Stress Debriefing teams available to help them cope with the emotional aspects of treating exposed survivors should be part of contingency planning. By improving our readiness to respond to biological terrorism, many lives can be saved and terrorists denied their goal of creating panic and crisis throughout the country.
Evaluation of the role of CFTR in alcohol related pancreatic disease
Authors: J OCKENGA, M STUHRMANN, M P MANNS
Journal: Gut (2001)

Editor,—In up to 30% of patients with idiopathic pancreatitis (IP) a mutation of at least one or both alleles of the cystic fibrosis transmembrane conductance regulator (CFTR) gene can be identified.1-3 The study by Malats et al ((2001) Gut 48:70–4; [OpenUrl][1][Abstract/FREE Full Text][2]) addressed the question of whether CFTR mutations, possibly together with environmental factors such as alcohol, may be associated with chronic pancreatitis or pancreatic cancer. The vast majority of the pancreatic patients (86.4%) investigated by Malats et al were diagnosed as having alcoholic pancreatitis (AP), and 75.4% of the cancer patients were daily drinkers. The authors found no statistically significant difference in the prevalence of delta-F508 (0%; 2.4%) and the 5T allele (10.5%; 5.5%) in the AP or cancer groups compared with the expected prevalence in the general population. The lack of a positive association of both delta-F508 and the 5T allele with AP is neither surprising nor argues against involvement of CFTR variations in the development of AP, considering the following. In cystic fibrosis (CF), the degree of correlation … Dr Malats. nuria{at}imim.es [1]: {openurl}?query=rft.jtitle%253DGut%26rft.stitle%253DGut%26rft.aulast%253DDaniele%26rft.auinit1%253DB%26rft.volume%253D48%26rft.issue%253D1%26rft.spage%253D28%26rft.epage%253D33%26rft.atitle%253DOral%2Bglutamine%2Bin%2Bthe%2Bprevention%2Bof%2Bfluorouracil%2Binduced%2Bintestinal%2Btoxicity%253A%2Ba%2Bdouble%2Bblind%252C%2Bplacebo%2Bcontrolled%252C%2Brandomised%2Btrial%26rft_id%253Dinfo%253Adoi%252F10.1136%252Fgut.48.1.28%26rft_id%253Dinfo%253Apmid%252F11115819%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/ijlink?linkType=ABST&journalCode=gutjnl&resid=48/1/28&atom=%2Fgutjnl%2F49%2F2%2F312.2.atom