tbuckley/cabot-search huggingface dataset:
Abstract 140: A study on 15 patients with Kawasaki disease who underwent coronary bypass surgery at our hospital
Authors: Masao Ohtaka, Katsumi Akimoto, Asuka Nakamura, Mana Harada, Takeshi Furukawa, Hideo Fukunaga, Masahiro Ohtsuki, Ken Takahashi, Masahiko Kishiro, Toshiaki Shimizu
Journal: Circulation (2015)

Background: Kawasaki Disease (KD)-related coronary artery aneurysm results in stenotic lesions due to thrombus formation and intimal thickening. In its acute phase, KD may follow an acute course due to thrombotic occlusion leading to myocardial infarction. On the other hand, in the convalescent phase, it does not follow a rapid course due to the development of collateral circulation and often occurs with chest pain. In this study, we retrospectively analyzed the following variables in patients who underwent bypass surgery: clinical course until initiation of surgical treatment, indication of surgical treatment. Subjects and Methods: The subjects were 15 patients who underwent coronary artery bypass graft (CABG) surgery at our hospital (male:female ratio, 8:7; age, 24-58 years; mean age, 38.3 years). In these subjects, we examined the age at onset, period until initiation of surgical treatment, presence or absence of symptoms, radiographic findings, indications for surgical treatment, and operative methods. Results: The age at onset of KD was between 6 months and 12 years. For 3 patients, KD was not diagnosed in childhood and the diagnosis was based on calcification and chest radiography findings. The period from onset to surgical treatment ranged 7-42 years (mean, 25.6 years). Most of the subjects underwent surgical treatment during adulthood. Radiography showed bilateral lesions in 14 patients, complete occlusion of the right coronary artery in 5 patients, and calcification in 4 patients. Collateral circulation developed in all subjects who underwent surgical treatment during adulthood. Although exertional chest pain was observed in 9 patients, no patient required emergency CABG. Surgical treatment involving the bilateral inferior mesenteric arteries was performed in 14 patients. In 2 patients, a bulky mass was resected from the right coronary artery. Conclusion: The mean age at surgery was approximately 40 years. There were many subjects in whom the time elapsed since disease onset was long, which was presumably attributed to the development of collateral circulation. Therefore, it is necessary to examine such patients using diagnostic imaging or stress myocardial scintigraphy even if they are asymptomatic.
Diagnosis and Classification of Diabetes Mellitus
Journal: Diabetes Care (2009)

OF DIABETES MELLITUS -Diabetes is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both.The chronic hyperglycemia of diabetes is associated with long-term damage, dysfunction, and failure of differentorgans, especially the eyes, kidneys, nerves, heart, and blood vessels.Several pathogenic processes are involved in the development of diabetes.These range from autoimmune destruction of the ␤-cells of the pancreas with consequent insulin deficiency to abnormalities that result in resistance to insulin action.The basis of the abnormalities in carbohydrate, fat, and protein metabolism in diabetes is deficient action of insulin on target tissues.Deficient insulin action results from inadequate insulin secretion and/or diminished tissue responses to insulin at one or more points in the complex pathways of hormone action.Impairment of insulin secretion and defects in insulin action frequently coexist in the same patient, and it is often unclear which abnormality, if either alone, is the primary cause of the hyperglycemia.Symptoms of marked hyperglycemia include polyuria, polydipsia, weight loss, sometimes with polyphagia, and blurred vision.Impairment of growth and susceptibility to certain infections may also accompany chronic hyperglycemia.Acute, life-threatening consequences of uncontrolled diabetes are hyperglycemia with ketoacidosis or the nonketotic hyperosmolar syndrome.Long-term complications of diabetes include retinopathy with potential loss of vision; nephropathy leading to renal failure; peripheral neuropathy with risk of foot ulcers, amputations, and Charcot joints; and autonomic neuropathy causing gastrointestinal, genitourinary, and
Medical liability reform
Authors: C. T. Yarington
Journal: JAMA (1988)

<h3>To the Editor.—</h3> I write concerning the recent article by Dr Abraham<sup>1</sup>on medical liability reform in the July 1 issue of<i>JAMA</i>. He mentions one-way and two-way fee shifting as mechanisms to limit litigation, but states that two-way fee shifting might reduce access to the courts by less prosperous plaintiffs who have otherwise meritorious claims. I suggest that another mechanism to limit litigation, which apparently has had success elsewhere, is for a system of two-way fee shifting in which a losing defendant pays the costs of the plaintiff, including legal fees (as now exists), but in which a losing plaintiff pays all costs incurred by the victorous defendant, including legal fees. Should the plaintiff be indigent or otherwise unable to pay this cost, the burden would shift to the plaintiff's attorney, and bond would be required prior to litigation to ensure that both parties could meet this potential
MECHANISM OF THE VESICANT ACTION OF MUSTARD GAS
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
EMERGENCY MEDICAL RELIEF AND THE CIVIL WORKS ADMINISTRATION
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Distinguishing Central Nervous System Lymphoma from Toxoplasma Encephalitis
Authors: Howard A. Fine
Journal: Annals of Internal Medicine (1994)

Letters1 May 1994Distinguishing Central Nervous System Lymphoma from Toxoplasma EncephalitisHoward A. Fine, MD and Robert J. Mayer, MDHoward A. Fine, MDDana-Farber Cancer Institute; Havard Medical School; Boston, MA 02115Search for more papers by this author and Robert J. Mayer, MDDana-Farber Cancer Institute; Havard Medical School; Boston, MA 02115Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-120-9-199405010-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We agree with Dr. Marra that in a patient with AIDS who has a single intracerebral lesion and a negative serum anti-toxoplasmosis IgG, the likelihood of toxoplasmosis encephalitis is small. In such a case, proceeding directly to biopsy is reasonable. Thallium-SPECT scanning and assessment of Epstein-Barr virus DNA in cerebrospinal fluid are promising new diagnostic modalities; however, their value in differentiating between cerebral toxoplasmosis and lymphoma has not been tested in large-scale, prospective trials. In general, if some chance exists that newly diagnosed intracerebral lesions are the result of toxoplasmosis and the patient is neurologically stable, we believe ... Author, Article, and Disclosure InformationAffiliations: Dana-Farber Cancer Institute; Havard Medical School; Boston, MA 02115 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1994Volume 120, Issue 9Page: 812-813KeywordsBiopsyCentral nervous systemCerebrospinal fluidDNAEncephalitisEpstein-Barr virusLesionsLymphomaToxoplasmaToxoplasmosis ePublished: 15 August 2000 Issue Published: 1 May 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Resurgence of scabies
Authors: M. Orkin
Journal: JAMA (1971)

This study on the current status of scabies is based upon information obtained from a survey form completed by 86 American and 73 foreign dermatologists, and comprehensive review of the world literature. Although the disease became uncommon in the 1950s, there has been since 1963 and 1964 a progressive increase in scabies in many parts of the world, to epidemic proportions in some areas. The epidemic has not yet involved the United States or Canada, except for sporadic outbreaks and small foci (mainly hippies). The cause of this recent resurgence is not clear; demographic and immunologic considerations seem particularly worthy of further study.
Response to Letters Regarding Article, “Aspirin Plus Clopidogrel Versus Aspirin Alone After Coronary Artery Bypass Grafting: The Clopidogrel After Surgery for Coronary Artery Disease (CASCADE) Trial”
Authors: Alexander Kulik, Michel R. Le May, Pierre Voisine, Jean-Claude Tardif, Robert DeLarochelliere, Sarika Naidoo, George A. Wells, Thierry G. Mesana, Marc Ruel
Journal: Circulation (2011)
Phase II study of gemcitabine, trastuzumab, and pertuzumab for HER2-positive metastatic breast cancer after prior pertuzumab-based therapy
Authors: N.M. Iyengar, L.M. Smyth, D. Lake, A. Gucalp, J.C. Singh, T.A. Traina, P. Defusco, M.N. Dickler, M.N. Fornier, S.B. Goldfarb, K. Jhaveri, S. Modi, T. Troso-Sandoval, K. Jack, G. Ulaner, M. Jochelson, J. Baselga, L. Norton, C.A. Hudis, C.T. Dang
Journal: Annals of Oncology (2017)
Injuries associated with three-wheeled, all-terrain vehicles, Alaska, 1983 and 1984
Authors: S. M. Smith
Journal: JAMA (1986)

From January 1983 through December 1984, twenty deaths and at least 534 injuries in Alaska were associated with three-wheeled, all-terrain vehicles. Age at death ranged from 12 to 53 years; 15 deaths (75%) were in the 15- to 34-year age group. Of the 20 fatalities, 12 (60%) might have been prevented had the riders been wearing a helmet. Alcohol use was detected or highly suspected as the major contributing cause of the fatal crash for 12 of 15 drivers and three of five female passengers. Potential risk factors for injuries associated with all-terrain vehicles include alcohol use, failure to use helmets, rider inexperience and inattention, and excessive speed. (<i>JAMA</i>1986;255:2454-2458)
THE ALLEGED FREQUENCY OF INSANITY AMONG FARMERS.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MOUTH-BREATHING.
Authors: JAMES M. CRAWFORD
Journal: JAMA (1899)

My paper has reference to those cases where mouth-breathing is the rule and not the exception. If one will take the pains to minutely examine the interior of the nose and its function, he will not be surprised to learn that there is a penalty for those who persistently use the mouth as a breathing apparatus. The object of nasal breathing is twofold, to moisten and to warm the air before its reception into the bronchial tubes. We need not be surprised, then, if many cases of bronchitis are caused by mouth-breathing, the cold and dry air coming in contact with the bronchial tubes and air-cells, causing congestion, and later inflammation. The same condition often causes asthma. We no longer attribute mouth-breathing to habit, and scold the patient for not breathing through the nose, but on the contrary, we know that in these cases there is an obstruction in the
Abdominal pain
Authors: A. Sadiq, M. Hershman, D. Luke, D. Durrans, D. Wells
Journal: BMJ (2011)

A 14 year old girl was referred by her general practitioner with a two week history of abdominal pain, nausea, and vomiting. At presentation the pain had become localised to the right iliac fossa. No bowel or urinary symptoms were reported. Her last menstrual period had started one week previously. Ten days previously, she had been seen by the paediatrics team with symptoms of diarrhoea, frequency, and dysuria associated with a dull suprapubic ache. On the basis of these symptoms and a positive nitrate urine dipstick, a diagnosis of urinary tract infection was made and a five day course of trimethoprim prescribed. On general examination she seemed mildly dehydrated, with a pulse of 115 beats/min and a respiratory rate of 24 breaths/min. Her temperature was 37.1°C, and her blood pressure was 122/92 mm Hg. Abdominal examination showed tenderness in the right iliac fossa with localised guarding and rigidity, tympanic percussion, and reduced bowel sounds. Examination of other systems was unremarkable. Urine dipstick and pregnancy testing were negative, and capillary blood sugar was 3.9 mmol/L. Blood investigations showed haemoglobin at 13.3 g/L (reference range 11.5-16 g/dL, total white blood cell count 17.7 x 109/L (4.0-11.0 x 109), mean corpuscular volume 82.3 fl (76-96 fl), platelets 561 x 109/L (150-400 x 109), sodium 138 mmol/L (135-145), potassium 4.4 mmol/L (3.5-5.0), urea 7.5 mmol/L (2.5-6.7), and creatinine 57 µmol/L (79-118). ### 1 What are the differential diagnoses and which is the most likely? #### Short answer Differential diagnoses include:
Text-Book of Pediatrics.
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TRICHOPHYTON ROSACEUM
Authors: ROBT. A. BOLAM
Journal: British Journal of Dermatology (1912)

IN England cases of ringworm due to the Trichophyton rosaceum have not been recorded in any great number.Adamson, in 1908 (l), exhibited before the Dermatological Section of the Royal Society of Medicine the first case recognised in this country.Subsequently (1909) Whitfield (2) drew attention to a second case of beard ringworm due to the same parasite, Two further cases giving similar cultures were reported by Haldin Davis (3).Sabouraud, in his classical work Lss Teignes, says that this special inoculation in man is very rare, for in seven years, and out of 800 cultures, he only encountered this variety eight times.It is now well recognised, largely as an outcome of his work, that in different countries, or even districts, it may be anticipated that the varieties of fungi found in apparently similar clinical lesioiis may differ widely.In certain parts of the Continent the rarity of Trichophyton rosaceum would seem not to be so pronounced as in France, since Dalla Fnvera ( 5 ) has recorded a number of cases occurring in Parrna, aud his statistics show that this variety forms sornethiiig like 4 per cent. of all trichophytons studied in the course of his researches.I have been fortunate enough to meet with a considerable number of cases in the North of England, and to encounter lesions due to this fungus, which show that the early generalisations on their clinical aspects require to aome extent revision, as, iudeed, Sabournud has himself pointed out (6). 'l'hus he desoribes the lesions as epidermic
Primary biliary cirrhosis: Prediction of short-term survival based on repeated patient visits
Authors: P MURTAUGH
Journal: Hepatology (1994)

The progression of primary biliary cirrhosis was studied in 312 patients who were seen at the Mayo Clinic between January 1974 and May 1984. Follow-up was extended to April 30, 1988, by which time 140 of the patients had died and 29 had undergone orthotopic liver transplantation. These patients generated 1,945 patient visits that enabled us to study the change in the prognostic variables of primary biliary cirrhosis (age, bilirubin value, albumin value, prothrombin time and edema) from the time of referral. Also, using this database and the Cox proportional-hazards regression model, we developed an updated model for primary biliary cirrhosis that can be used to predict short-term survival at any time in the course of the disease. This model uses the values of the prognostic variables measured at the latest patient visit. Comparison of predicted survival from the update model and the natural history model of primary biliary cirrhosis showed that the updated model was superior to the original model for predicting short-term survival. This finding applied to both the Mayo Clinic patients and an independent set of 83 Dutch patients. The Mayo updated model is recommended for improving the accuracy of predictions of survival during the 2 yr after a patient visit. (Hepatology 1994;20:126–134.
Francis Delafield and T. Mitchell Prudden, a Hand-book of Pathological Anatomy and Histology.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Multifunctional Receptor Model for Dioxin and Related Compound Toxic Action: Possible Thyroid Hormone-Responsive Effector-Linked Site
Authors: James D. McKinney
Journal: Environmental Health Perspectives (1989)

Molecular/theoretical modeling studies have revealed that thyroid hormones and toxic chlorinated aromatic hydrocarbons of environmental significance (for which dioxin or TCDD is the prototype) have similar structural properties that could be important in molecular recognition in biochemical systems. These molecular properties include a somewhat rigid, sterically accessible and polarizable aromatic ring and size-limited, hydrophobic lateral substituents, usually contained in opposite adjoining rings of a diphenyl compound. These molecular properties define the primary binding groups thought to be important in molecular recognition of both types of structures in biochemical systems. Similar molecular reactivities are supported by the demonstration of effective specific binding of thyroid hormones and chlorinated aromatic hydrocarbons with four different proteins, enzymes, or receptor preparations that are known or suspected to be involved in the expression of thyroid hormone activity. These binding interactions represent both aromatic-aromatic (stacking) and molecular cleft-type recognition processes. A multiple protein or multifunctional receptor-ligand binding mechanism model is proposed as a way of visualizing the details and possible role of both the stacking and cleft type molecular recognition factors in the expression of biological activity. The model suggests a means by which hormone-responsive effector-linked sites (possible protein-protein-DNA complexes) can maintain highly structurally specific control of hormone action. Finally, the model also provides a theoretical basis for the design and conduct of further biological experimentation on the molecular mechanism(s) of action of toxic chlorinated aromatic hydrocarbons and thyroid hormones.