tbuckley/cabot-search huggingface dataset:
NECROLOGY.
Authors: William B. Atkinson
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Artificial Corneal Endothelium Tested
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
American Journal of Psychiatry, Hanover, NH
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effects of cytokines on the liver
Authors: T Andus
Journal: Hepatology (1991)

A complex network of mediator molecules constitutes a communication system coordinating different cells and tissues within the body, thus maintaining or restoring physiological homeostasis.In the past few years, progress in molecular immunobiology has led to the characterization of a still growing number of hormonelike proteins that, besides the classical hormones, mediate the interaction between different cells and tissues.These hormonelike proteins are called cytokines or peptide regulatory factors (1-5).Most of these cytokines are glycoproteins with a molecular mass below 80,000 Da.Cells involved in cytokine synthesis include blood cells such as monocytes, lymphocytes, neutrophils and platelets; stromal cells such as fibroblasts, endothelial cells and smooth muscle cells; and epithelial cells such as keratinocytes and hepatocytes.Cytokines usually act in picomolar concentrations through specific high-affinity cell surface receptors.In contrast to the classical hormones, they act mainly in a paracrine and autocrine manner on neighboring cells and themselves, but they can also act in an endocrine manner on distant cells.A single cytokine may not only be produced by a variety of cell types in response to different stimuli but may also have multiple biological effects on different target cells (Table 1).Most cytokines have been identified by analyzing mediator molecules responsible for the dramatic changes occurring during inflammation.Cytokines represent the signal substances causing the changes during the inflammatory response such as fever, leukocytosis and thrombocytosis, immune responses and the hepatic acute-phase response.Most of what we know about the effects of cytokines is related to inflammatory events.Therefore little is known about cytokine functions under normal physiological conditions.Until now these could only be deduced from the knowledge of their action during inflammation.Molecular cloning of cytokines has allowed the study of the effects of pure cytokines i n vitro and in viuo, and such an approach will help us learn more about their functions.Not only does the liver play a pivotal role as a major organ of intermediary metabolism, but it also partici-
European Perspectives
Journal: Circulation (2012)

Professor Bodi has received 4 research grants as principal investigator from the Spanish Society of Cardiology over the past 8 years.The projects have investigated the evolution of left ventricular volumes and systolic function after acute myocardial infarction and the role of the coronary microcirculation (funded in 2004), the prognostic value of vasodilator stress perfusion cardiac magnetic resonance in patients with known or suspected ischaemic heart disease (2007), acute deregulation of the immune system in acute myocardial infarction and assessment of experimental therapeutic options (2008), and the efficacy of local gene therapy for reducing infarct size and microvascular obstruction in a swine model of myocardial infarction (2009).The 2004 and 2007 grants were used in the design and management of databases and development of a core lab on cardiac imaging, enabling a line of research on the pathophysiology and risk stratification of ischaemic heart disease using cardiac magnetic resonance.This allowed
Final Stages of Poliomyelitis Eradication—Western Pacific Region, 1997-1998
Journal: JAMA (1999)

In 1988, the World Health Assembly resolved to eradicate poliomyelitis globally by 2000. A plan of action for polio eradication in the Western Pacific Region (WPR) by 1995 was adopted in 1990. The plan was based on routine and supplemental vaccination activities with oral poliovirus vaccine (OPV) and acute flaccid paralysis (AFP) surveillance in the eight countries where polio was endemic (Cambodia, China, Laos, Malaysia, Mongolia, Papua New Guinea, Philippines, and Vietnam). Regionwide, the number of reported polio cases decreased from approximately 6000 in 1990 to zero in 1998. This report describes the extensive efforts to eliminate the last chains of poliovirus transmission in the Mekong River area.
A Primer on the Prevention of Deformity in Childhood
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Die aesthetische Erscheinungsweise der Farben.
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Aging Better
Authors: Edward W. Campion
Journal: New England Journal of Medicine (1998)

Eighteen years ago, the Journal published an article entitled “Aging, Natural Death, and the Compression of Morbidity,” which has been widely cited and hotly debated ever since.1 The author, James Fries, challenged the assumption that the aging of a population is necessarily accompanied by an increasing amount of disability and functional impairment. At least in the developed societies of the world, improvements in public health, nutrition, and medical care have led to large declines in the numbers of deaths in childhood, youth, and middle age. Most people can now expect to live for a period approaching a full life span. . . .
Cardiovascular responses to serotonin in experimental liver disease
Authors: G Jacob
Journal: Hepatology (1991)

Recent evidence suggests that serotonergic mechanisms within the cardiovascular system are activated and may be important in the development of the hyperkinetic circulation and the maintenance of portal hypertension in cirrhotic patients. The in vivo pressor and positive chronotropic response together with the in vitro contractile responses of aortic rings and portal veins to serotonin were studied in three different rat models of cirrhosis, portal hypertension and jaundice: the portal vein–ligated rat, the carbon tetrachloride–induced cirrhotic rat, the chronic bile duct–ligated cirrhotic rat and the 3-day noncirrhotic, nonportal hypertensive–jaundiced rat. In addition, the activity of the enzyme monoamine oxidase type A was determined in lung homogenates prepared from the four groups of sham and treated animals. In the four different groups of sham-treated or operated pithed rats, serotonin caused a dose-dependent increase in mean arterial blood pressure without any effect on the heart rate. The pressor responses to serotonin in the three models of portal hypertension were significantly attenuated from their respective sham group. In the 3-day noncirrhotic, nonportal hypertensive–jaundiced rats, the pressor response was no different than that seen in the sham-operated rats. No evidence of consistent potentiated or blunted in vitro reactivity to serotonin of arterial rings and portal veins from the four groups of rats was seen. Portal hypertension, cirrhosis and hyperbilirubinemia had no effect on the activity of monoamine oxidase type A. These data demonstrate that portal hypertension is associated with an attenuated pressor response to serotonin. The mechanism of this attenuated response is not linked to altered in vitro reactivity of arterial rings to serotonin or increases in the activity of pulmonary monoamine oxidase. Because the in vitro reactivity of portal veins from portal hypertensive rats was not hypersensitive to serotonin, our data are consistent with the proposal that serotonin2-antagonists exert their portal hypotensive action by lowering resistance in the mesenteric and collateral circulation of cirrhotic patients. (HEPATOLOGY 1991;14:1235–1242).
Book Review pathologic de l'Appareil Circulatoire (Coeur et Vaisseaux) . Two volumes comprising Section X of the Nouveau Traité de Médecine edited by Roger, Widal, Teissier and Garnier. Masson et Cie, Paris, 1933. Tome I, 135 fr. Tome II, 115 fr.
Journal: New England Journal of Medicine (1933)
A model for primary care delivery to a widely dispersed medically indigent population
Authors: V. Bigelow
Journal: JAMA (1991)

Access to Care is a unique program uniting private and public resources to provide primary care to the uninsured poor. The model was designed to serve a medically indigent population that is dispersed over a large geographic area, where clinics are not a practical option. Care for illness is provided in the offices of private physicians throughout the area and supported by laboratory, radiology, and pharmacy services. The program is designed for the estimated 88 000 persons in suburban Cook County, Illinois, with family incomes of less than twice the federal poverty level, who are uninsured and ineligible for Medicaid and Medicare. Supported by grants from foundations and local governments, the program, which has been in operation for 2 years in two demonstration areas, is administered by a private not-for-profit confederation of four health and social service organizations. (<i>JAMA</i>. 1991;266:563-564)
2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines
Authors: Paul K. Whelton, Robert M. Carey, Wilbert S. Aronow, Donald E. Casey, Karen J. Collins, Cheryl Dennison Himmelfarb, Sondra M. DePalma, Samuel Gidding, Kenneth A. Jamerson, Daniel W. Jones, Eric J. MacLaughlin, Paul Muntner, Bruce Ovbiagele, Sidney C. Smith, Crystal C. Spencer, Randall S. Stafford, Sandra J. Taler, Randal J. Thomas, Kim A. Williams, Jeff D. Williamson, Jackson T. Wright
Journal: Circulation (2018)
Presidential Address
Authors: H. Strotzka, Marianne Ringler, Elisabeth Jandl-Jager, N.H. Groenman, H.C. Sauër, Maurizio Fava, Giovanni A. Fava, Robert Kellner, Maire T. Buckman, Jonathan Lisansky, Emanuela Serafini, Leopoldo DeBesi, Ismaele Mastrogiacomo, G. Koptagel-Ilal, Ö. Tunçer, G. Enbiyaoğlu, Z. Bayramoğlu, A.C. Woodmansey, Wolfram Schüffel, Deirdre Paulley, Ian G. Tait, Chase Patterson Kimball, Peter E. Sifneos, George Spyros Philippopoulos, Xenia Lucas, Grethe Rasmussen, Truls-Eirik Mogstad, Walter Hewer, J.W. Paulley, Ronald Grossarth-Maticek, Dusan T. Kanazir, Hermann Vetter, Peter Schmidt, H. Kordy, M. von Rad, W. Senf, R.M. Rosser, C.M. Moynihan, J. Denford, A. Heslop, B. Muir, D. Macklin, A. Guz, H.-C. Deter, G. Allert, D.G. Byrne, W. Langosch, G. Brodner, H. Borcherding, R. Beunderman, D.J. Duyvis, J. van Dixhoorn, J. de Loos, H.J. Duivenvoorden, R.A. Ramsay, F. Engelsmann, Heinz G.F. Schepank, Peter J. Cooper, Dennis H. Gath
Journal: Psychotherapy and Psychosomatics (1983)
Abnormal insulin molecules: an alternative cause of diabetes?
Authors: T. Ziporyn
Journal: JAMA (1984)

"Diabetes i^iabetes is a heterogeneous group of disorders. It's already quite clear that we cannot diagnose it as one condition, but clearly there are multiple factors and causes which all can give rise to the common end point of hyperglycemia." So says Arthur H. Rubenstein, MD, Lowell T. Coggeshall Professor of Medical Sciences and chair of medicine at the University of Chicago's Pritzker School of Medicine, who spoke at the AMA's recent Third Annual Conference for Science Writers in Chicago. According to Rubenstein, the present characterization of diabetes into type I and type II is too simplistic: "We now are beginning to dissect out numerous causes." <h3>"We now are beginning to dissect out numerous causes."</h3> Besides autoimmunity or insulin resistance, possible causes suggested by work in the past two or three years include abnormal insulins and insulin precursors, circulating antibodies that bind insulin, and circulating antagonists that impair the action
Reproductive toxicology. Ethylene glycol monomethyl ether.
Authors: Robert Chapin, Dushyant Gulati, Esther Hope, Robin Mounce
Journal: Environmental Health Perspectives (1997)

FWmore sensitive otn F,? Yes Postnal toxicity.Yes Legend:-, no change; e, no observation; , or 1, statistically significant change (p0.05); - no change in males or females
Software
Authors: Mark T. Parker
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Efficacy and Safety of Trastuzumab as a Single Agent in First-Line Treatment of <i>HER2</i>-Overexpressing Metastatic Breast Cancer
Authors: Charles L. Vogel, Melody A. Cobleigh, Debu Tripathy, John C. Gutheil, Lyndsay N. Harris, Louis Fehrenbacher, Dennis J. Slamon, Maureen Murphy, William F. Novotny, Michael Burchmore, Steven Shak, Stanford J. Stewart, Michael Press
Journal: Journal of Clinical Oncology (2002)

PURPOSE: To evaluate the efficacy and safety of first-line, single-agent trastuzumab in women with HER2-overexpressing metastatic breast cancer. PATIENTS AND METHODS: One hundred fourteen women with HER2-overexpressing metastatic breast cancer were randomized to receive first-line treatment with trastuzumab 4 mg/kg loading dose, followed by 2 mg/kg weekly, or a higher 8 mg/kg loading dose, followed by 4 mg/kg weekly. RESULTS: The objective response rate was 26% (95% confidence interval [CI], 18.2% to 34.4%), with seven complete and 23 partial responses. Response rates in 111 assessable patients with 3+ and 2+ HER2 overexpression by immunohistochemistry (IHC) were 35% (95% CI, 24.4% to 44.7%) and none (95% CI, 0% to 15.5%), respectively. The clinical benefit rates in assessable patients with 3+ and 2+ HER2 overexpression were 48% and 7%, respectively. The response rates in 108 assessable patients with and without HER2 gene amplification by fluorescence in situ hybridization (FISH) analysis were 34% (95% CI, 23.9% to 45.7%) and 7% (95% CI, 0.8% to 22.8%), respectively. Seventeen (57%) of 30 patients with an objective response and 22 (51%) of 43 patients with clinical benefit had not experienced disease progression at follow-up at 12 months or later. The most common treatment-related adverse events were chills (25% of patients), asthenia (23%), fever (22%), pain (18%), and nausea (14%). Cardiac dysfunction occurred in two patients (2%); both had histories of cardiac disease and did not require additional intervention after discontinuation of trastuzumab. There was no clear evidence of a dose-response relationship for response, survival, or adverse events. CONCLUSION: Single-agent trastuzumab is active and well tolerated as first-line treatment of women with metastatic breast cancer with HER2 3+ overexpression by IHC or gene amplification by FISH.
IL-2 Adenovector-Transduced Autologous Tumor Cells Induce Antitumor Immune Responses in Patients With Neuroblastoma
Authors: Laura Bowman, Michael Grossmann, Donna Rill, Michael Brown, Wan-yun Zhong, Barbara Alexander, Thasia Leimig, Elaine Coustan-Smith, Dario Campana, Jesse Jenkins, Diane Woods, Geoffrey Kitchingman, Elio Vanin, Malcolm Brenner
Journal: Blood (1998)
GW28-e0219 Chronic exercise training modulated the autonomic nervous system imbalance without increasing the incidence of spontaneous arrhythmia in myocardial infarction mice
Authors: Rujie Qin, Nobuyuki Murakoshi, DongZhu Xu, Kazuko Tajiri, Duo Feng, Endin Nokik Stujanna, Saori Yonebayashi, Akira Koike, Kazutaka Aonuma
Journal: Journal of the American College of Cardiology (2017)
Tetracyclina in Tractamento de Febre "Q"
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal