tbuckley/cabot-search huggingface dataset:
PARIS
Journal: JAMA (1953)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
EUROPEAN LETTER.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cutaneous Herpesvirus hominis (type 2) infection after renal transplantation
Authors: K. K. Arora
Journal: JAMA (1974)

In an unusual case of disseminated herpesvirus hominis type 2 infection after renal transplantation, survival of the patient and maintenance of graft function were accomplished while immunosuppressive therapy was reduced to allow healing of the cutaneous lesions. (<i>JAMA</i>230:1174-1175, 1974)
Alopecia areata in children: treatment with diphencyprone
Authors: M-LA. SCHUTTELAAR, J.J. HAMSTRA, E.P.B. PLINCK, J.D.R. PEEREBOOM-WYNIA, V.D. VUZEVSKI, P.G.H. MULDER, A.P. ORANJE
Journal: British Journal of Dermatology (1996)
Choosing an antidepressant.
Journal: BMJ (1978)

component appears to be polygenic.What is not inherited, it appears, is the rate of rise of blood pressure with advancing years-though this rise does not seem to alter the ranking order for height of pressure in groups observed at intervals.Kass and his colleagues13 studied this "tracking" phenomenon and found that blood pressure ranking was relatively stable in groups of children studied over an eight-year period.The crucial question may well be how early in life we can detect the combination of an inherited blood pressure level and a "tracking" pattern that will expose an individual to un- acceptable cardiovascular risk in later life.De Swiet et al14 have suggested that an infant's blood pressure at four to six days correlates significantly with its pressure at five to seven weeks, while Kass and his colleagues13 have shown that "sibling to sibling aggregation of blood pressure ... probably begins during the first few -months of life and mother-child aggregation seems to be present -from the first days of life."Clearly the best precaution a newborn baby can take over its arterial blood pressure and therefore its cardiovascular risk in later life is to choose its parents carefully.
PMO-230 Clinical risk factors for Crohn's disease postoperative recurrence are reflected in alterations in mucosally adherent microbiota at surgical resection
Authors: A U Murugananthan, D O Bernardo, P Tozer, A L Hart, S C Knight, K Whelan, N Arebi, H O Al-Hassi
Journal: Gut (2012)

<h3>Introduction</h3> Clinical risk factors for Crohn9s disease (CD) recurrence after ileo-caecal resection (ICR) include smoking status, perforating disease and &gt;1 surgical resection. The underlying mechanisms contributing to clinical risk are unknown. We aimed to study the relationship between risk factors and gut microbiota. <h3>Methods</h3> Samples of macroscopically inflamed and non-inflamed small bowel from patients undergoing surgical resection for CD were analysed. Samples were snap frozen in liquid nitrogen. Cryosections were cut and the frozen sections were hybridised with oligonucleotide probes targeting the microbial 16S rRNA of total bacteria, <i>Escherichia coli</i>, Bacteroides-Prevotella, <i>Faecalibacterium prausnitzii</i>, <i>Clostrium coccoides</i>- <i>Eubacterium rectale</i> and bifidobacteria. The hybridised mucosa associated microbiota (MAM) were identified and quantified. Patients with ≥1 risk factor were classified as high risk for disease recurrence. <h3>Results</h3> Fifteen patients underwent ICR (10 female); 9 were high risk (6 smokers, 4 fistulating disease and 2 recurrent resection- 3 patients had multiple risk factors). <i>Faecalibacterium prausnitzii</i> numbers in inflamed operative samples were lower in smokers compared with non-smokers (p=0.036). High-risk patients had lower numbers of bifidobacteria in both inflamed (p=0.006) and non-inflamed (p=0.01) operative samples compared with low risk patients. <h3>Conclusion</h3> The risk of post-operative CD recurrence may be predetermined at a pre-operative stage due to dysbiosis. The role of MAM as a tool to stratify risk requires further study. Drugs that modulate MAM may, in future, play a role in reducing post-operative recurrence. <h3>Competing interests</h3> None declared.
Management of Severe Injury of Spinal Cord of Civilians
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Painful iceberg.
Authors: F G Fowkes, A Ferguson
Journal: BMJ (1981)

The clinical features of the multiple pterygium syndrome are multiple congenital joint contractures, multiple skin webs, camptodactyly, vertebral anomalies, short stature, ptosis, and antimongoloid eye slant. We present 11 new cases to show the evolution of the full phenotype from birth and to confirm autosomal recessive inheritance. We emphasise morbidity secondary to respiratory impairment and that conductive deafness may be part of the syndrome.
The Neel of National Quarantine.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A World Malaria Map: Plasmodium falciparum Endemicity in 2007
Authors: Simon I Hay, Carlos A Guerra, Peter W Gething, Anand P Patil, Andrew J Tatem, Abdisalan M Noor, Caroline W Kabaria, Bui H Manh, Iqbal R. F Elyazar, Simon Brooker, David L Smith, Rana A Moyeed, Robert W Snow
Journal: PLoS Medicine (2009)

Background Efficient allocation of resources to intervene against malaria requires a detailed understanding of the contemporary spatial distribution of malaria risk. It is exactly 40 y since the last global map of malaria endemicity was published. This paper describes the generation of a new world map of Plasmodium falciparum malaria endemicity for the year 2007. Methods and Findings A total of 8,938 P. falciparum parasite rate (PfPR) surveys were identified using a variety of exhaustive search strategies. Of these, 7,953 passed strict data fidelity tests for inclusion into a global database of PfPR data, age-standardized to 2–10 y for endemicity mapping. A model-based geostatistical procedure was used to create a continuous surface of malaria endemicity within previously defined stable spatial limits of P. falciparum transmission. These procedures were implemented within a Bayesian statistical framework so that the uncertainty of these predictions could be evaluated robustly. The uncertainty was expressed as the probability of predicting correctly one of three endemicity classes; previously stratified to be an informative guide for malaria control. Population at risk estimates, adjusted for the transmission modifying effects of urbanization in Africa, were then derived with reference to human population surfaces in 2007. Of the 1.38 billion people at risk of stable P. falciparum malaria, 0.69 billion were found in Central and South East Asia (CSE Asia), 0.66 billion in Africa, Yemen, and Saudi Arabia (Africa+), and 0.04 billion in the Americas. All those exposed to stable risk in the Americas were in the lowest endemicity class (PfPR2−10 ≤ 5%). The vast majority (88%) of those living under stable risk in CSE Asia were also in this low endemicity class; a small remainder (11%) were in the intermediate endemicity class (PfPR2−10 > 5 to < 40%); and the remaining fraction (1%) in high endemicity (PfPR2−10 ≥ 40%) areas. High endemicity was widespread in the Africa+ region, where 0.35 billion people are at this level of risk. Most of the rest live at intermediate risk (0.20 billion), with a smaller number (0.11 billion) at low stable risk. Conclusions High levels of P. falciparum malaria endemicity are common in Africa. Uniformly low endemic levels are found in the Americas. Low endemicity is also widespread in CSE Asia, but pockets of intermediate and very rarely high transmission remain. There are therefore significant opportunities for malaria control in Africa and for malaria elimination elsewhere. This 2007 global P. falciparum malaria endemicity map is the first of a series with which it will be possible to monitor and evaluate the progress of this intervention process.
Correction
Journal: Thorax (2016)

Corrections have been made to the 'Results' section of this abstract.The changes are in bold.Results 73 patients presented with a PSP.34 patients required chest tube drainage, 25 of which were managed as an outpatient with a Pneumostat.The median LOS in the outpatient group was 1.0 day (IQR 0.0-2.0days) vs 4.0 days (IQR 2.0-7.0 days) in the inpatient group.A total of 99 bed days were saved using the device.Based on a cost of £25.70 per Pneumostat and £312 per bed day, the overall saving was £30,245.50.Patients who required thoracic surgery were kept on the "inpatient waiting list" and could be admitted directly from home.In the outpatient group, there was 1 drain site infection, 1 drain displacement and 1 patient failed to attend follow-up but returned a week later with a resolved pneumothorax.
Physical Fitness
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Book: Incontinence
Authors: C. J Fowler
Journal: BMJ (2000)

Eds Malcolm Lucas, Simon Emery, John Beynon ![Graphic][1]</img> Blackwell Science, £69.50, pp 384 ISBN 0 632 05003 9 Rating:![Graphic][2]</img>![Graphic][3]</img>![Graphic][4]</img>![Graphic][5]</img> The idea that there are boundary walls in the pelvis labelled “urology,” “gynaecology,” and “coloproctology” which surgeons must not cross is a view now losing ground, and this book, which covers urinary and faecal incontinence, supports the modern approach. This has been possible because the three editors are consultant surgeons at Swansea NHS Trust in urology, obstetrics and gynaecology, and colorectal surgery respectively … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif [4]: /embed/inline-graphic-4.gif [5]: /embed/inline-graphic-5.gif
Neurological Manifestations of Angioedema
Authors: Theodore R. Sunder
Journal: JAMA (1982)

Two children had recurrent neurological symptoms associated with angioedema. Extensive clinical and laboratory investigations failed to reveal a separate cause for the neurological changes. Only 19 prior cases of this association have been reported. Seizures and headaches are the most common symptoms, but a wide variety of focal and generalized deficits may occur. The release of vasoactive substances such as histamine, serotonin, and prostaglandins, which are also putative neurotransmitters, is postulated to be the cause of the cerebral symptoms. (<i>JAMA</i>1982;247:2005-2007)
T-Cell Mutation Leads to GI Polyps
Journal: Cancer Discovery (2018)

Peutz-Jeghers syndrome, a cancer predisposition syndrome that causes benign gastrointestinal polyps, results from a germline mutation in a single allele of STK11, the gene that encodes for LKB1. Researchers established a possible mechanism for how a STK11 mutation in T cells could lead to polyps associated with the syndrome.
Adrenogenital Syndrome: Absence of Vagina with Pregnancy and Successful Delivery
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A randomized trial (MA.17R) of extending adjuvant letrozole for 5 years after completing an initial 5 years of aromatase inhibitor therapy alone or preceded by tamoxifen in postmenopausal women with early-stage breast cancer.
Authors: Paul E. Goss, James N. Ingle, Kathleen I. Pritchard, Hyman Muss, Julie Gralow, Karen A. Gelmon, Timothy Joseph Whelan, Kathrin Strasser-Weippl, Sheldon Rubin, Keren Sturtz, Antonio C. Wolff, Eric P. Winer, Clifford A. Hudis, Alison Stopeck, J. Thaddeus Beck, Judith Salmon Kaur, Kate Whelan, Dongsheng Tu, Wendy R. Parulekar
Journal: Journal of Clinical Oncology (2016)

LBA1 The full, final text of this abstract will be available at abstracts.asco.org at 7:30 AM (EDT) on Sunday, June 5, 2016, and in the Annual Meeting Proceedings online supplement to the June 20, 2016, issue of the Journal of Clinical Oncology. Onsite at the Meeting, this abstract will be printed in the Sunday edition of ASCO Daily News.
Epidemic Hepatitis
Authors: Prem N. Wahi, M. M. Arora
Journal: New England Journal of Medicine (1953)

AN epidemic of hepatitis occurred in Uttar Pradesh, India, during the months of May to September, 1949. Some of the 88 patients studied had been admitted to S. N. Hospital and the Military Hospital in Agra and to the P. L. Sharma Hospital, Police Hospital and Dufferin Hospital in Meerut.There were various clinical diagnoses (Table 1). Twenty patients died. Liver biopsy was performed in most cases.Three adult patients, as well as 4 fetuses of women with fulminant epidemic hepatitis who later died, were completely studied at autopsy. In these 88 cases, 20 of which were fatal, 37 patients . . .
The DREAM Protein Is Associated to Thyroid Enlargement and Nodular Development
Authors: Marcos Rivas, Britt Mellström, Begoña Torres, Gaetano Cali, Alfonso M. Ferrara, Daniela Terracciano, Mariastella Zannini, Gabriella Morreale de Escobar, Jose R. Naranjo
Journal: Endocrine Reviews (2009)

G protein-coupled receptors (GPCR) are involved in the pathophysiology of a wide range of diseases and constitute an attractive therapeutic target. In the thyroid gland, thyroid-stimulating hormone receptor (TSHR), a member of the GPCR family, is a major regulator of thyroid differentiation and function. Alterations in TSHR activity are often involved in the development of pathologies such as thyroid cancer and thyroid enlargement (goiter). Here we show that DREAM (downstream regulatory element antagonist modulator) modulates TSHR activity through a direct protein-protein interaction that promotes coupling between the receptor and Gαs. In transgenic mice, DREAM overexpression provokes a marked enlargement of the thyroid gland. Increased levels of DREAM protein were observed in human multi-nodular goiters, suggesting a novel etiopathogenic mechanism in nodular development in humans. Taken together, these findings identify a mechanism for the control of TSHR activity and provide a new approach for the study and treatment of thyroid pathologies associated with impaired TSHR function.
In This Issue
Journal: Journal of Clinical Investigation (2007)

Sensing inflammatory painPARs are a subfamily of G protein-coupled receptors that share a unique mechanism of activation and are known to play important roles in the response to tissue inflammation.TRPA1 is a member of the transient receptor potential (TRP) family of cation channels that has been reported to be activated by icilin, a chemical that induces a cooling sensation, and by temperatures of 17°C or less and thus is proposed to be the painful cold receptor.Here, Dai and colleagues, using morphological and electrophysiological analyses, show a functional interaction of these two inflammation-related molecules in primary rat sensory neurons (pages 1979-1987).A PAR2-activating peptide increased the TRPA1 currents evoked by allyl isothiocyanate (AITC) or cinnamaldehyde in HEK293 cells expressing TRPA1 as well as in primary sensory neurons.This potentiation was inhibited by phospholipase C inhibitors; however, its downstream PKC activation was not involved in the AITC- or cinnamaldehyde-activated TRPA1 currents.This potentiation mechanism is different from that in TRPV1 currents.These findings reveal a novel mechanism through which mediators of tissue inflammation might trigger the sensation of pain by TRPA1 activation.
1O Inducible T cell co-stimulatory (ICOS) receptor agonist, GSK3359609 (GSK609) alone and combination with pembrolizumab: Preliminary results from INDUCE-1 expansion cohorts in head and neck squamous cell carcinoma (HNSCC)
Authors: C. Le Tourneau, D. Rischin, S. Groenland, A. Lim, J. Martin-Liberal, V. Moreno, J.M. Trigo, M. Mathew, D. Cho, A. Hansen, D. Vincente Baz, M. Maio, A. Italiano, J. Bauman, M. Chisamore, H. Zhou, C. Ellis, M. Ballas, A. Hoos, E. Angevin
Journal: Annals of Oncology (2020)