tbuckley/cabot-search huggingface dataset:
Acute hemolytic anemia with Mycoplasma pneumoniae pneumonia
Authors: D. F. Turtzo
Journal: JAMA (1976)

A patient was seen with severe hemolysis due to cold antibodies associated with<i>Mycoplasma pneumoniae</i>pneumonia. Therapy with tetracycline hydrochloride, prednisone, and folic acid was initiated, and complete recovery ensued. Data is presented documenting the presence of autoimmune hemolysis due cold agglutinins associated with<i>Mycoplasma</i>infection. (<i>JAMA</i>236:1140-1141, 1976)
Incorrect Value in Table
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sickle-cell trait and altitude.
Authors: N Pashley, R Felix
Journal: BMJ (1972)

barium meal three days after admission suggested a shallow erosion high on the posterior aspect of the lesser curve of the stomach.Clinically there was no evidence of further bleeding.He was started on soluble insulin and timed blood sugars were in the range of 150-175 mg/100 ml.Ten days after admission fibreoptic gastro- scopy under intravenous diazepam3 was performed by one of us (R.H.F.).The gastric mucosa was studded with punctate areas compatible with a diffuse gastritis.The pylorus contracted normally with some bile reflux and no evidence of ulceration was seen.At follow up in another hospital five and a half weeks later, our patient was well and free of any gastric symptoms.His diabetes had been difficult to manage, with hypoglycaemic attacks on soluble insulin 12 units in the morning, 8 units each evening, and a 200 g carbohydrate diet.He had gained 6-1 kg in weight.We suggest that this patient's anorexia, epigastric discomfort and pain, weight loss, and ultimate gastric haemorrhage were due to overdosage with phenformin.-Weare,
Suprasellar aneurysm. An unusual cause of hypopituitarism
Authors: V. V. Shantharam
Journal: JAMA (1974)

PANHYPOPITUITARISM, an uncommon clinical disorder, may result from a variety of underlying conditions. Chromophobe adenoma is perhaps the most frequent precipitating cause. Less common but confirmed causes include postpartum pituitary infarction, granulomatous disorders, head trauma, hemorrhage, suprasellar cyst, craniopharyngioma, and suprasellar aneurysm, which is presented here. <h3>Report of a Case</h3> A 55-year-old white woman was hospitalized because of a visual field defect. Additional complaints were bifrontal headache, 18-kg (40-lb) weight loss, alopecia, cold sensitivity, and increased sleep requirements. She denied having polydipsia, polyuria, or nocturia. She had been hypertensive for many years but had remained normotensive in the last 18 months without therapy. Her pregnancies had been uncomplicated, and she had reached an uneventful menopause at age 50 years. Vital signs were normal. The optic fundi showed mild congestion of retinal vessels but no papilledema, hemorrhage, or exudates. Visual field examination by perimetry showed a bitemporal hemianopsia. Axillary hair was
ATNT-14PHASE I STUDY OF PLERIXAFOR AND BEVACIZUMAB IN RECURRENT HIGH-GRADE GLIOMA
Authors: Eudocia Lee, Alona Muzikansky, Elizabeth Gerstner, John Kuhn, David Reardon, Lakshmi Nayak, Andrew Norden, Lisa Doherty, Jennifer Stefanik, Debra LaFrankie, Julee Pulverenti, Trupti Vardam, Deirdre Stokes, Katrina Smith, Christine McCluskey, Sarah Gaffey, Tracy Batchelor, Dan Duda, Rakesh Jain, Patrick Wen
Journal: Neuro-Oncology (2015)
EMPYEMA OF THE FRONTAL SINUS.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Colitis
Authors: D S Rampton
Journal: Gut (1993)

Non-steroidal anti-inflammatory drug- induced jejunal and colonic diaphragm disease EDITOR, -Fellows and his colleagues (Gut 1992; 33: 1424-6) claim that 'most previously reported cases have shown ileal disease and no case to date has shown involvement of the colon.'We would like to draw your attention to the fact that we published a case of diaphragm disease of the colon in the April issue of Gastroenterology in 1991' several months before the case report of Fellows et al was published in Gut.We were more cautious in asking for priority and we stated 'that to our knowledge such a case had not been observed before.'The caution was indeed justified as we then saw several additional cases in a short time.We submitted this extended case report for publication to a well honoured British journal and we were informed that our cases did not contribute to the better understanding of this established condition.Moreover, Dr H Spiro, the editor of Clinical Gastroenterology, where the paper was subsequently accepted for pub- lication,2 was kind enough to draw our atten- tion to an earlier publication of two such cases in the Lancet, in 1989.Additionally we found a recent report in endoscopic studies.4We thus agree with a Lancet editorial in 1989 that colonic damage by non-steroidal anti- inflammatory drugs is probably very common.5It is of interest that all the seven cases we have seen up to now were treated with diclofenac, applied in slow release form, and it is possible that we have seen a whole series of such cases in less than two years as this drug is manufactured in Switzerland and is the most common non- steroidal anti-inflammatory drug in use in our country.It is nevertheless appreciated
News and Notices
Journal: British Journal of Dermatology (1988)

British Journal of DermatologyVolume 119, Issue 5 p. 690-690 News and Notices First published: November 1988 https://doi.org/10.1111/j.1365-2133.1988.tb03488.xAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume119, Issue5November 1988Pages 690-690 RelatedInformation
Epidemiology and Cytogenetics of Conjoined Twins
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Phase I Dose Escalation Study Of TGR-1202, a Novel PI3K-δ Inhibitor, For Patients With Relapsed Or Refractory Hematologic Malignancies
Authors: Michael Savona, Martin Gutierrez, Mark Lanasa, Changchun Deng, John Kuhn, Lauren Sade, Hari Miskin, Peter Sportelli, Swaroop Vakkalanka, Manish Patel
Journal: Blood (2013)
AB0040 Toll-like receptor 9 influences inflammatory arthritis and osteoclastogenesis
Authors: A. Fischer, S. Abdollahi-Rodsaz, A.C.Y. Yau, E. Lönnblom, B. Meyer, B. Niederreiter, R. Holmdahl, G. Steiner
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Release and insufficient removal of endogenous nucleic acids may be involved in triggering autoimmune reactions important in the initiation of systemic autoimmune diseases including rheumatoid arthritis (RA). Nucleic acid sensing molecules, such as the endosomal Toll-like receptors (TLRs) 7 and 9, have been linked to pathogenic autoimmune processes, but their role in RA is less clear. Data obtained in rats with pristane-induced arthritis (PIA) suggested involvement of TLR9 in the pathogenesis of this arthritis model<sup>1</sup>. <h3>Objectives</h3> To gain more insight into the role of TLR9 in autoimmune arthritis, TLR9 inhibition with specific oligodeoxynucleotide sequences (ODN)<sup>2</sup> was investigated in rats with PIA. To further investigate TLR9 involvement, streptococcal cell wall (SCW) arthritis was induced in TLR9<sup>-/-</sup> mice. <h3>Methods</h3> Arthritis was induced in mice with SCW lysates and in rats with the mineral oil pristane. Rats were treated with a TLR9 antagonist, starting before disease induction. Arthritis was scored using established scoring systems, inflammation and bone erosion were quantified by histological analysis. Levels of α−1-acid-glycoprotein (AGP), rheumatoid factor (RF) and IL-6 in sera were analysed. The role of TLR9 in osteoclast differentiation and activation was investigated <i>in vitro</i>. <h3>Results</h3> In PIA, the TLR9 antagonist reduced arthritis severity by ~50%, which was accompanied by a reduction of AGP, IL-6 and RF. TLR9 inhibition led to reduced inflammation, bone erosion and cartilage degradation. Moreover, the T cell-dependent chronic phase of SCW arthritis was significantly suppressed in TLR9<sup>-/-</sup> mice. Remarkably, TLR7 and TLR9 mRNA levels strongly differed in the course of <i>in vitro</i> osteoclastogenesis. Whereas TLR7 expression did not change throughout osteoclastogenesis, expression of TLR9 was higher in precursor cells than in mature osteoclasts and stimulation with a TLR9 agonist (CpG) completely inhibited osteoclastogenesis. <h3>Conclusions</h3> Taken together, the results suggest a role for TLR9 in the T cell-dependent phases of PIA and SCW arthritis thus an important involvement of the DNA (CpG) recognising TLR9 in the initiation of autoimmune arthritis and during osteoclastogenesis. The precise role(s) of TLR9 in the different stages of arthritis needs to be further elucidated in future experiments. <h3>References</h3> [1] Hoffmann MH, et al. Nucleic acid-stimulated antigen-presenting cells trigger T cells to induce disease in a rat transfer model of inflammatory arthritis. J Autoimmun, 2011;36(3–4):288–300. [2] Duramad O, et al. Inhibitors of TLR-9 act on multiple cell subsets in mouse and man in vitro and prevent death in vivo from systemic inflammation. J Immunol, 2005;174(9):5193–200. <h3>Disclosure of Interest</h3> None declared
Physiotherapy in Dermatology
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
NORWAY
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prophylactic use of hydrochlorothiazide in pregnancy
Authors: G. W. Kraus
Journal: JAMA (1966)

A randomized double-blind investigation of the early, continuous, prophylactic use of hydrochlorothiazide (50 mg daily) was undertaken with 1,030 obstetrical patients. Twenty-eight percent of the patients were teenagers and 39% were nulliparas. Hypokalemia and hyperuricemia were significantly increased in the hydrochlorothiazide group, but the patients were asymptomatic. The total incidence of hypertension was 19.6% in the hydrochlorothiazide group and 21.8% in the placebo group. Preeclampsia occurred in 3% of the former group and in 3.8% of the latter. Excessive weight gain was evident in 13.9% of the placebo group as compared to 7.7% of the hydrochlorothiazide group (<i>P</i>= 0.002). The average fetal weight and the incidence of prematurity, congenital anomalies, and perinatal mortality were similar in both groups. No complications related to thiazides were encountered in the 1,040 newborns. The data demonstrated that long-term, prophylactic use of hydrochlorothiazide in pregnancy did not alter the incidence of preeclampsia, hypertension, prematurity, congenital anomalies, or perinatal mortality.
慢性荨麻疹患者发生精神疾病的风险更高: 一项基于人群的研究
Authors: C.Y. Chu, Y.T. Cho, J.H. Jiang, C.C. Chang, S.C. Liao, C.H. Tang
Journal: British Journal of Dermatology (2020)

慢性荨麻疹 (CU) 是一种皮肤病,可导致持续至少六周的瘙痒性荨麻疹。这是一种常见疾病,影响全球 0.6% 至 0.8% 的人群。CU 会影响患者的生活质量、学业和工作表现。 尽管最近的一些研究已经探讨了精神疾病和荨麻疹的关系,但在大的人群中,尚不清楚 CU 患者各种精神疾病的相对风险和精神药物使用。 在这项研究中,作者旨在通过 CU 严重程度探讨 CU 患者精神疾病的患病率(普遍程度)和相对风险或精神药物的使用。这是中国台湾的一项基于人群的研究。 作者发现,CU 患者患精神疾病的风险是普通人群的 1.43 倍至 2.32 倍,并且开具精神药物处方的频率更高。 作者得出结论,心理健康评估和管理是 CU 管理中的重要元素。 本摘要涉及研究: 慢性荨麻疹患者发生精神疾病的风险更高: 一项基于人群的研究
MISCELLANY.
Authors: None Medicus
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Involvement of RNA in Protein Synthesis
Authors: Jonathan R. Warner, Ruy Soeiro
Journal: New England Journal of Medicine (1967)

Binding of tRNA to Ribosomes The binding of tRNA to ribosomes has been extensively studied with both bacterial and mammalian systems. There is a reaction between the 30S portion of the ribosome, poly U, and tRNA specific for phenylalanine.56 The presence of 50S ribosomes in this reaction mixture doubles the amount of tRNA bound. However, the 50S ribosomes by themselves, or in the presence of poly U, bind very little phenylalanyl tRNA. This reaction is specific in the sense that other types of tRNA will not bind to the ribosome-poly U complex, and the phenylalanyl-tRNA will not bind to the . . .
Tetanus
Authors: Louis Weinstein
Journal: New England Journal of Medicine (1973)

THE etiologic agent of tetanus is an anaerobic spore-forming rod, Clostridium tetani. None of the clinical manifestations of the disease are produced by tissue injury but result from the activity of a soluble exotoxin, tetanospasmin, which is elaborated at the site of injury by vegetative forms of the organism. Tetanus, usually an infrequent disorder in the well developed parts of the world, is common in some underdeveloped countries.Cl. tetani, in the vegetative form, is a gram-positive, slender motile rod. The sporulated form is characteristically drumstick or tennis racket in appearance, with the spore at the terminal end . . .
Methods for and Approaches to Evaluating Susceptibility of Ecological Systems to Hazardous Chemicals
Authors: Joanna Burger
Journal: Environmental Health Perspectives (1997)

Differences in genetic susceptibility to hazardous chemicals affect individuals of both human and nonhuman populations.In both cases, differences in response to chemicals or general ill health result as a function of these differences in genetic susceptibility.However, ecological systems are a compilation of hundreds or even thousands of different species, resulting in structural and functional characteristics that are themselves affected by differences in susceptibility.Although individual and population differences in susceptibility to hazardous chemicals underlie effects at the community and the ecosystem level, they do not account for all differences.propose a two- tiered approach to evaluating susceptibility to ecological systems: a general susceptibility as a function of ecosystem type (based on structure and function of that system) and a differential in susceptibility within broad ecosystem types as a function of biotic and abiotic factors.In terrestrial ecosystems, the two factors that most affect overall susceptibility are species diversity and hydrology; evaluation of the effects of hazardous chemicals involves measuring species diversity and water movement.This same methodological approach can be applied to aquatic ecosystems and to highly altered ecosystems such as agriculture, forestry, fisheries, and urbanization.
Training fellowships for intervention
Journal: Eurosurveillance (2001)

The European Programme for Intervention Epidemiology Training started in 1995. The programme is funded by the European Commission, various European Union (EU) member states, and Norway. Subject to agreement for another round of funding, the eighth cohort of fellows is planned to start in September 2002. The programme invites applications for eight fellowships for this 24-month training programme in communicable disease field epidemiology.
Pediatric Nephrology
Authors: Donald I. Moel
Journal: JAMA (1987)

Pediatric nephrology is a young sub-specialty that emerged from its infancy with the development of techniques to dialyze and perform transplants in children in the late 1960s and early 1970s. The first edition of<i>Pediatric Nephrology</i>, edited by Mitchell I. Rubin and T. Martin Barratt in 1975, was the first general textbook of pediatric nephrology. It was 927 pages long and gave a comprehensive view of pediatric nephrology; it was highly descriptive and practical. Another comprehensive text-book,<i>Pediatric Kidney Disease</i>, edited by C. M. Edelmann, was published in 1978. Pediatric nephrologists have long awaited the second edition of both books. The new<i>Pediatric Nephrology</i>, edited by Malcolm A. Holliday, T. Martin Barratt, and Robert L. Vernier, is targeted to a wide range of readers from pediatric nephrologists to medical students. In contradistinction to the first edition, this book is not a practical guide to pediatric nephrology. Like many of the
PARIS
Journal: JAMA (1925)

<h3>Clinical Types of Pulmonary Gangrene</h3> At the recent congress of medicine in Nancy, Drs. Bezançon and De Jong presented an excellent paper on clinical types of pulmonary gangrene. They emphasized that the term "pulmonary gangrene" had become more comprehensive recently. At present the conception includes all fetid suppurations of the lung. Most commonly they are complications of bronchial dilatation; less frequently they are caused by septic pulmonary embolism, air-borne infection or tracheal deglutition of food or pus. Primary types follow general weakening or are without assignable cause. The authors distinguish three principal types: 1. An acute type (the embolic type); with genuine septicemia; signs of localization lacking or not discoverable till late. In this Rist emphasized the diagnostic significance of thoracic pain. 2. An acute type with signs of localization; genuine pneumonia, rapid spreading and cavitation. Here the onset may be sudden and the evolution rapid; in other cases the