tbuckley/cabot-search huggingface dataset:
PWE-028 HALO radiofrequency ablation for high grade dysplasia and early mucosal neoplasia arising in Barrett's oesophagus: interim results form the UK HALO radiofrequency ablation registry
Authors: R J Haidry, J Dunn, M Banks, A Gupta, M A Butt, H Smart, P Bhandari, L-A Smith, R Willert, G Fullarton, M Di Pietro, I Penman, H Barr, C Gordon, P Patel, P Boger, N Kappor, B Mahon, M Burnell, M Novelli, L B Lovat
Journal: Gut (2012)

<h3>Introduction</h3> Barrett9s oesophagus (BE) is the pre-cursor to oesophageal adenocarcinmoa (OAC). High grade dysplasia (HGD) and early mucosal neoplasia in BE has historically been treated with surgery. Recently there is a shift towards minimally invasive endotherapy with endoscopic mucosal resection (EMR) and Radiofrequency ablation (RFA). <h3>Methods</h3> Prospective registry from 14 UK centers to audit RFA outcomes in patients with HGD and early neoplasia in BE. Prior to RFA, any visible lesions were first removed by EMR. Patients then underwent RFA 3 monthly until all visible BE was ablated or cancer developed. Biopsies were taken at the end of this protocol. <h3>Results</h3> 216 patients have completed protocol, mean age 68.6 years (40–90), 81% male. Mean time to protocol end 11.3 months (IQR 8–14.3), median 2 ablations and mean of 2.4 (2–6) during protocol with mean 1.4 circumferential ablations and 1.2 focal ablations performed during protocol. Mean length BE segment ablated is 5.8 cm (1–20). CR-HGD was achieved in 83% patients at protocol end biopsy. CR-D was 76% and CR-BE 50% at this point. CR-D was more likely in short segment BE (&lt;5 cm) at protocol end (82% vs 54%, p&lt;0.0001, Fisher9s exact test). Patients who required EMR during RFA protocol were less likely to achieve CR-D than those who had RFA alone (52% vs 79%, p=0.002, fishers exact test). 3.7% patients progressed to invasive cancer at protocol end. Complications include one perforation and 1% incidence of superficial tears. 37 patients have at least 12 months or more follow-up after successful completion of protocol (range 12–42), median 16.2 months. Durability in these is excellent with 95% dysplasia free at most recent biopsy. <h3>Conclusion</h3> This is the largest series to date of patients undergoing RFA from 14 UK centers. End of protocol CR-D is satisfactory at 76% and successful eradication appears to be durable. Patients with short segment BE are likely to respond better. Our data represent real life outcomes of integrating minimally invasive endotherapy into demanding endoscopy service commitments. <h3>Competing interests</h3> None declared.
The Chemical Laboratory
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sarcoidosis of the Skull
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE SPECIFICITY OF HEMOLYTIC STREPTOCOCCI
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Journal of Surgical Research, Philadelphia
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Getting the Word Out on Lead
Journal: Environmental Health Perspectives (1995)

hillsides."We have no idea why," said Morrison."It would just be wild speculation to give a reason."Mice belonging to this genus include deer mice, brush mice, and white-footed mice.They generally weigh about an ounce and are a few inches long.Morrison says his findings will be com- piled with those of researchers doing simi- lar studies in different geographical regions of the state to try to determine when hantavirus infection is highest in rodents and thus when it may most likely be spread to humans.With such information, people can be told to be careful in certain habitats or to avoid being near rodents during cer- tain times of year.Although the chances of contracting HPS are low, according to Levy, concern is high because one out of two people who get the disease die.For the present, Levy advises avoiding all contact with rodents and making sure homes are rodent-proofed by caulking and sealing holes and other possible entrances. Frauenfelder Straddles BorderIn November 1993, the North American Free Trade Agreement (NAFTA) created the Border Environment Cooperation Commission (BECC) to deal with envi- ronmental issues along the U.S.-Mexican border.Last February, the U.S.
Treatment of acute respiratory acidosis in chronic obstructive lung disease
Authors: L. J. Kettel
Journal: JAMA (1971)

In the treatment of 87 episodes of acute respiratory acidosis in 62 patients with chronic obstructive lung disease, the basic approach to therapy was maintenance of adequate arterial oxygenation by low-flow controlled oxygen supplementation, with relatively infrequent use of intubation and controlled ventilation. The overall survival rate of 71.3% (62 patients survived episode, 25 died) compares favorably with survival rates of other reported series in which artificial ventilation was emphasized, especially when one considers the severity of the episodes and the nature of the disease.
Evaluation of long-term use of propranolol in angina pectoris
Authors: E. A. Amsterdam
Journal: JAMA (1969)

The effect of propranolol hydrochloride therapy for angina pectoris was evaluated by double-blind trial in 121 patients with the anginal syndrome. Ninety-five patients had coronary artery disease, and 26 had normal coronary arteries. Successful therapy was achieved in 83 patients (86%) with coronary artery disease, whereas only six (23%) with normal coronary arteries responded favorably. Not distinguishing features could be found between those patients with coronary artery disease successfully treated with propranolol and those who failed to respond. Side effects occurred in 31% of the patients but necessitated withdrawal of treatment in only two instances. These results indicate that propranolol is highly effective in the prolonged treatment of angina pectoris when this is caused by coronary atherosclerosis and the dose of drug is individualized for each patient.
Dyspareunia
Authors: T. Robinson
Journal: BMJ (1955)

Decisions have to be made about allocating health resources. Currently the best economic evaluation method for doing this is cost-utility analysis. This compares the costs of different procedures with their outcomes measured in "utility based" units--that is, units that relate to a person9s level of wellbeing. The most commonly used unit is the quality adjusted life year (QALY). QALYs are calculated by estimating the total life years gained from a procedure and weighting each year to reflect the quality of life in that year. To compare outcomes of different programmes the Rosser index is one measure that is widely used to assign quality of life scores to patients. Combined with a measure of life years gained from a procedure, this enables QALYs to be calculated and procedures ranked according to cost per QALY gained. In this article Ray Robinson explains the measures used and discusses how QALY league tables can be used to guide decisions on resource allocation.
THE ANTIVIVISECTION QUESTION.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Eighty-Five
Authors: Barbara Quick
Journal: Annals of Internal Medicine (2013)

Ad LibitumDecember 17, 2013Eighty-FiveBarbara QuickBarbara QuickFrom Cotati, California.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-159-12-201312170-00005 Audio Reading - “Eighty-Five” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Eighty-Five," by B. Quick. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Eighty-five nowand living your life in a placeyou never called home.From your windows you look at it every day:your son's house, where he lives with his newest wife.Only sometimes it seems certainthat he is your husband, six years dead, not your son.When you see his car and your dogs bark their joy,he turns the wrong way—toward that house.Toward her.The ... Author, Article, and Disclosure InformationAffiliations: From Cotati, California.Current Author Address: Barbara Quick; e-mail, [email protected]. PreviousarticleNextarticle Advertisement Audio Reading - “Eighty-Five” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Eighty-Five," by B. Quick. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics December 17, 2013Volume 159, Issue 12Page: 805 ePublished: 17 December 2013 Issue Published: December 17, 2013 Copyright & PermissionsCopyright © 2013 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
THE PERMANENT LOCATION.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Insight
Authors: Elizabeth B Gay
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Error in Figure
Authors: Chittaranjan Andrade
Journal: JAMA Neurology (2016)

Nicole Reams, MD; James T. Eckner, MD, MS; Andrea A. Almeida, MD; Andrea L. Aagesen, DO; Bruno Giordani, PhD; Hank Paulson, MD; Matthew T. Lorincz, MD, PhD; Jeffrey S. Kutcher, MD
Five Years of the Kahn Test.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
GENE-07. MOLECULAR NEUROPATHOLOGY 2.0 - INCREASING DIAGNOSTIC ACCURACY IN PEDIATRIC NEUROONCOLOGY
Authors: Dominik Sturm, David T.W. Jones, David Capper, Felix Sahm, Andreas von Deimling, Stefan Rutkoswki, Monika Warmuth-Metz, Brigitte Bison, Marco Gessi, Torsten Pietsch, Stefan M. Pfister
Journal: Neuro-Oncology (2017)

aggressive surgery (gross total resection x 6) followed by involved field radiation therapy (XRT), with a median event-free survival of 6 months and 4 of 8 patients dead of disease.Frequent and potentially targetable genetic alterations were detected in the MAPK pathway in 4 of 8 cases (BRAF V600E x 3, NTRK2-BEND5) and in PI3K/MTOR pathway genes in 3 of 8 cases (TSC1 x 2, PTEN).Additional aberrations related to the MAPK pathway were identified in 4 patients, including high copy gains in MET and KIT and 2 novel fusions (SOS1-MAP4K3 and MAP3K11-GFAP) which were validated by targeted sequencing and require further functional characterization.Other alterations in known high-grade glioma genes were also detected, including homozygous CDKN2A/B loss (n=3), TP53 mutation (n=2), and amplification events involving MYCN, CDK6, MET, and KIT.CONCLUSION: MEGNT is an aggressive tumor with poor response to conventional therapies.The frequency of potentially-targetable molecular alterations identified in this study indicates an opportunity to test the use of novel targeted agents for children with these tumors.
THE INTRAVENOUS USE OF CORPUS LUTEUM EXTRACT IN NAUSEA OF PREGNANCY
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
UTERINE INERTIA
Authors: L. Clark Hepp
Journal: JAMA (1953)

During the past two decades, marked changes have occurred not only in the teaching but also in the practical application of obstetrics. The "watchful waiting" of some of the best teachers and clinicians has been replaced by sound knowledge and thoughtful application of facts learned, instead of the noninterference advocated formerly. The "newer obstetrics" inquires into the factors that cause uterine inertia, with sound clinical judgment used in determining when passive expectancy should be replaced with active help for the patient. Many teachers are now beginning to teach what they practice rather than to practice radicalism and to teach conservatism. This approach has resulted from the realization that so-called normal labor can result in great harm to both mother and child. A prolongation of either the first or second stage of labor due to inertia may lead to fetal damage if the condition is not corrected by a sane approach
Guides to the Evaluation of Permanent Impairment
Authors: Mark E. Battista
Journal: JAMA (1989)

The third edition of the<i>Guides</i>will be a major asset to those who are not already owners/users of the second, published in 1984. No other authoritative document has such a finely honed collection of impairment classifications or comes even close to the sophistication of measurement indices this provides. The potential value of the<i>Guides</i>far transcends its common use in the evaluation of Workers' Compensation claimants. Of course, virtually every physician involved in any aspect of the disability benefits matrix<sup>1</sup>will find it valuable, and there is much evidence of a greater demand for expertise in this area.<sup>2,3</sup>The<i>Guides</i>continues to emphasize the distinction between impairment and disability. One cannot help but wonder, though, if the emphasis is diminished by adherence to the concept of percentage impairment of the whole person. While providing a relative measure of the severity of impairment, the primary use of the