Hemorrhagic Stroke Probably Caused by Exercise Combined With a Sports Supplement Containing β-Methylphenyl-ethylamine (BMPEA): A Case Report
Authors: Pieter A. Cohen, Rickard Zeijlon, Rachel Nardin, Peter H.J. Keizers, Bastiaan Venhuis
Journal: Annals of Internal Medicine (2015)

Letters16 June 2015Hemorrhagic Stroke Probably Caused by Exercise Combined With a Sports Supplement Containing β-Methylphenyl-ethylamine (BMPEA): A Case ReportPieter A. Cohen, MD, Rickard Zeijlon, MD, Rachel Nardin, MD, Peter H.J. Keizers, PhD, and Bastiaan Venhuis, PhDPieter A. Cohen, MDFrom Harvard Medical School, Boston, Massachusetts; Sahlgrenska University Hospital, Gothenburg, Sweden; and National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands., Rickard Zeijlon, MDFrom Harvard Medical School, Boston, Massachusetts; Sahlgrenska University Hospital, Gothenburg, Sweden; and National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands., Rachel Nardin, MDFrom Harvard Medical School, Boston, Massachusetts; Sahlgrenska University Hospital, Gothenburg, Sweden; and National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands., Peter H.J. Keizers, PhDFrom Harvard Medical School, Boston, Massachusetts; Sahlgrenska University Hospital, Gothenburg, Sweden; and National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands., and Bastiaan Venhuis, PhDFrom Harvard Medical School, Boston, Massachusetts; Sahlgrenska University Hospital, Gothenburg, Sweden; and National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/L15-0106 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Background: The U.S. Food and Drug Administration has warned consumers that an isomer of amphetamine, β-methylphenylethylamine (BMPEA), is found in many sports supplements (1). The health effects of this chemical in humans are unknown (2, 3).Objective: To report a case of hemorrhagic stroke probably caused by exercise combined with BMPEA.Case Report: A 53-year-old woman presented with 1 day of numbness and clumsiness in her left hand. She reported the sudden onset of symptoms 45 minutes after beginning a vigorous exercise routine that she had repeated several times weekly for a few years.On examination, she was afebrile, blood ...References1. U.S. Food and Drug Administration. BMPEA in dietary supplements. 24 April 2015. Accessed at www.fda.gov/food/dietarysupplements/qadietarysupplements/ucm443790.htm on 28 April 2015. Google Scholar2. Pawar RS, Grundel E, Fardin-Kia AR, Rader JI. Determination of selected biogenic amines in Acacia rigidula plant materials and dietary supplements using LC-MS/MS methods. J Pharm Biomed Anal. 2014;88:457-66. [PMID: 24176750] doi:10.1016/j.jpba.2013.09.012 CrossrefMedlineGoogle Scholar3. Cohen PA, Bloszies C, Yee C, Gerona R. An amphetamine isomer whose efficacy and safety in humans has never been studied, β-methylphenylethylamine (BMPEA), is found in multiple dietary supplements. Drug Test Anal. 2015. [PMID: 25847603] doi:10.1002/dta.1793 CrossrefMedlineGoogle Scholar4. Zeijlon R, Andersson B. Hjärnblödning efter intag av prestationshöjaren "Jacked Power." Frisk kvinna insjuknade under träning efter en enda dos. Läkartidningen. 2014;111:1782-4. [PMID: 25699325] MedlineGoogle Scholar5. Edwards IR, Aronson JK. Adverse drug reactions: definitions, diagnosis, and management. Lancet. 2000;356:1255-9. [PMID: 11072960] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Harvard Medical School, Boston, Massachusetts; Sahlgrenska University Hospital, Gothenburg, Sweden; and National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOf InterestForms.do?msNum=L15-0106.This article was published online first at www.annals.org on 12 May 2015. 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