tbuckley/cabot-search huggingface dataset:
Are coronary artery spasm and progressive damage to the heart associated with the hyperventilation syndrome?
Authors: L. J Freeman, P G F Nixon
Journal: BMJ (1985)

Samples of serum and cerebrospinal fluid obtained before, during, and after the period of treatment with adrenocorticotrophic hormone and plasmapheresis were assayed for complement fixing antibrain antibodies' and found to react with homogenate of human white matter (1:30 wt/vol in veronal buffer).The IgG class of the antibodies was shown by absorption and elution on Protein A-Sepharose CL-4B (Pharmacia, Sweden).Before plasmapheresis the IgG index was 0 74 and the cerebrospinal fluid antibody index' for antibrain antibodies was 27-4 (upper normal limit=2).Whereas treatment with adrenocorticotrophic hormone did not seem to affect the serum level of antibrain antibodies, plasmapheresis caused them to be virtually eliminated from serum concomitant with a pronounced drop in I ~~~~~~~IgG n
AMERICAN ASSOCIATION OF OBSTETRICIANS AND GYNECOLOGISTS.
Authors: Adam H Wright
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Recovery from acute subdural hematoma
Authors: S. A. Shatsky
Journal: JAMA (1979)

<h3>To the Editor.—</h3> It was gratifying to see what M. Seth Hockman, MD, said (241:2783, 1979) regarding the successful neurological recovery of a 49-year-old patient with a panhemispheric acute subdural hematoma. We believe, however, that his point— what the present standard of neurosurgical practice is—must be much more strongly made to the medical community. The author's first statement, "the development of fixed pupils following transtentorial herniation is such an ominous prognostic sign that only rarely have reports appeared that cite recovery from it," should be taken quite literally, that simply there have been few reports of recovery. This is not at all to say that the great majority of practicing neurosurgeons have not accumulated numerous patients who have recovered. As US Army staff neurosurgeons, we have in the past two years had five patients recover from neurological deterioration as bad as or even worse than that described. The most recent
Cancer of the gastrointestinal Tract. D. Gastric cancer: treatment principles
Authors: P. Rubin
Journal: JAMA (1974)

DESPITE the gains in therapeutic techniques, there has been no major improvement in the long-term survival of patients with stomach cancer. The detection of gastric cancer through clinical and roentgenographic findings pronounces a death sentence on the patient; merely the overt recognition of this cancer is a sign of advancement. Most clinical reports read the same<sup>1,2</sup>: for every 100 patients, 60 to 80 undergo exploratory surgery; resections are performed in 30 to 40, and 5% to 15% survive, depending on the number of patients in whom disease is limited to the stomach. Marshall<sup>3</sup>has shown that the five-year survival decreases from 34.8% to 7.2% when lymph nodal invasion occurs. This is the most critical factor in determining prognosis; lymph node invasion is present in two thirds of patients who undergo resection.<sup>3</sup> There is little correlation between the aggressiveness of surgical resection and the ultimate outcome for the patient. The
Abstract 143: Clinical Consideration of Kawasaki Disease Development in Younger and Older Children
Authors: Kenzo Sakurai
Journal: Circulation (2015)

Background: Kawasaki disease (KD) is an acute febrile illness of childhood. Most KD patients are children aged from 6 months to 4 years, although a small number of cases occur in children less than 6 months or over 5 years of age. KD symptoms are not easily observed in younger and older children, and so it is necessary to understand how the features of KD change with age. Objective: This study aimed to evaluate the clinical features of KD in children less than 6 months and greater than 5 years of age in our hospital. Methods: Patients diagnosed between October 2006 and September 2013 were divided into 2 groups: group A included 19 infants less than 6 months old and group B included 222 children who were more than 6 months old (1). On the other hand, patients were divided into another 2 groups: group C which included 219 children less than 5 years old and group D which included 29 children who were more than 5 years old (2). The features and symptoms of KD were compared between the groups; in particular, white blood cell counts, neutrophil ratios, platelet counts, total bilirubin, aspartate transaminase, alanine transaminase, sodium, C-reactive protein, fibrinogen, D-dimer, and intravenous immunoglobulin unresponsive scores were compared. Results: (1) Few infants less than 6 months old had changes in their extremities or cervical lymph node swelling; most of the infants less than 6 months old had incomplete KD. The neutrophil ratio before treatment tended to be significantly lower in infants less than 6 months old. (2) Most of the children over 5 years old had erythema, but few had significant cervical lymph node swelling. The neutrophil ratio before treatment tended to be significantly higher in infants over 5 years old. Discussion: The symptoms of KD are not easily observed in infants less than 6 months old, and so KD diagnosis can be difficult. KD in children over 5 years old is sometimes diagnosed as pyogenic cervical lymphadenitis, and these patients sometimes have to wait a long time to be diagnosed with KD. It is important to carefully observe the clinical progress of young infants with a continuing high fever and children diagnosed with pyogenic cervical lymphadenitis.
VA
Authors: Shelly Jones
Journal: Annals of Internal Medicine (1997)

Ad Libitum1 May 1997VAShelly Jones, MDShelly Jones, MDVeterans Affairs Medical Center, Des Moines, IA 50310Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-126-9-199705010-00012 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail “The usual ... Author, Article, and Disclosure InformationAffiliations: Veterans Affairs Medical Center, Des Moines, IA 50310Corresponding Author: Shelly Jones, MD, 6324 Northwest 56th Street, Johnston, IA 50131. Previousarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1997Volume 126, Issue 9Page: 736KeywordsBeerCoffeeDementiaLiverMeaslesNursesSubstance abuse Issue Published: 1 May 1997 CopyrightCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
PSROs and norms of care
Journal: JAMA (1974)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dual association of HLA DR2 and DR3 with primary sclerosing cholangitis
Authors: P Donaldson
Journal: Hepatology (1991)

Human leukocyte antigen typing was performed in 81 patients with primary sclerosing cholangitis to investigate reported associations between human leukocyte antigen type and this disease. The results showed a significant increase in the frequency of the antigens B8 and DR3 compared with controls (53% vs. 23%, p < 0.0005, and 56% vs. 21%, p < 0.0005). This was caused by a significant rise in the frequency of the human leukocyte antigen A1 B8 DR3 haplotype (32 of 81 patients, 40% vs. 12 of 100 patients, 12%, p < 0.0005). By contrast, a significant reduction was seen in the frequency of the antigens B44 and DR4 (12% vs. 31%, p < 0.005, and 12% vs. 34%, p p < 0.001, pc p < 0.011) because of the complete absence of the B44 DR4 haplotype in the patient group (p = 0.027, Fisher's exact test). When all the DR3-positive individuals (including the DR2/DR3 heterozygotes) were eliminated, a significant secondary association with DR2 was noted, 25 (69%) of 36 remaining patients being DR2-positive compared with 27 (34%) of 79 DR3 negative controls (p < 0.0005, pc p < 0.006). Only 9% of the patients were DR2-positive and DR3-positive. Kaplan-Meier analysis demonstrated that survival was not influenced by the presence of either haplotype nor by the individual antigens. Patients who were DR3-positive were first seen at a significantly younger age than those who were DR2-positive (mean ages = 33 yr and 44 yr, respectively, p p < 0.002, Student's t test). These data suggest that both human leukocyte antigen DR2 and the haplotype A1 B8 DR3 are independent factors that influence the initiation of PSC but do not determine the course of the disease. Furthermore, DR2 and DR3 may identify two etiological subsets of PSC. (HEPATOLOGY 1991;13:129–133).
Preclinical hemochromatosis in a population on a high-iron-fortified diet
Authors: K. S. Olsson
Journal: JAMA (1978)

Three hundred forty-seven (96.4%) of all persons aged 30 to 39 years were screened with serum iron and iron binding capacity measurements to determine the incidence of hemochromatosis in a population. No women had signs of iron overload; however, nine men (5%) had persistently elevated serum iron levels. In four men (2%), increased iron stores was found with a distribution like that in the early stages of hemochromatosis. In combination with recent findings of clinical hemochromatosis at our hospital, this study suggests that this condition is not as rare as has been reported earlier. (<i>JAMA</i>239:1999-2000, 1978)
Medico-Legal and Medico-Ethical
Journal: BMJ (1888)

The case of Mrs. Nunan is certainly hard, but it must be remembered that there are fixed rules with regard to pensions which cannot be departed from.In her case, however, I think that most likely the application was read by some junior clerk, who, in the flip-.pancy of youth, merely noted it as " against rule," and thought no more of theimatter.
Questions and Answers
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TRADEMARKS AND PROPRIETARY MEDICINES.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical Neurology of Aging
Authors: Charles M. Poser
Journal: JAMA (1985)

Few physicians today and even fewer tomorrow will be able to disclaim that they are gerontologists by acclamation rather than by choice, with the obvious exception of pediatricians and obstetricians. Most hospital services have found that the average age of their patients, regardless of specialty, has risen dramatically in the last five to ten years. In fact, as a practitioner of neurology, I find that to see a patient younger than age 65 years has become the exception rather than the rule. Until recently, we have ignored the very old in our descriptions of disease and, more important, in our evaluation of the normal. As more and more of us are destined to become not just elderly but very old, we wonder at those patients who in their 80s and 90s have retained all their mental faculties and lead enjoyable and even productive lives, while we commiserate with the children
Impact of Donor Serostatus on CMV Reactivation and Reconstitution of Multi-Function CMV-Specific T Cells in CMV-Positive Transplant Recipients
Authors: Wendi Zhou, Jeff Longmate, Simon F Lacey, Joycelynne Palmer, Ghislaine Gallez-Hawkins, Lia Thao, Ryotaro Nakamura, Ricardo Spielberger, Stephen J. Forman, John A. Zaia, Don J. Diamond
Journal: Blood (2008)
Abstract 853: Essential role of autocrine FGF19-FGFR4 signaling in head and neck tumorigenesis
Authors: Liwei Lang, Lixia Gao, Chloe Shay, Xiangdong Zhao, Austin Shull, Yong Teng
Journal: Cancer Research (2019)

Abstract The fibroblast growth factor 19 gene FGF19 has been reported to be amplified in several cancer types and encodes for a key autocrine signaler known to promote tumorigenic growth. Thus, it is imperative to understand which cancers are oncogenically addicted to FGF19 amplification as well as the role it serves in these cancer types. We report for the first time that high FGF19 amplification in head and neck squamous cell carcinomas (HNSCC) is associated with increased autocrine secretion of FGF19 and poor patient outcome in HNSCC. FGF19 amplification corresponded with constitutive activation of FGFR4-dependent ERK/AKT-p70S6K-S6 signaling, and addition of human recombinant FGF19 could promote proliferation and soft agar colony formation in HNSCC cells with low FGF19 expression through activating FGFR4 and downstream signaling cascades. Consistently, FGF19 knockout counteracted the observed effects in HNSCC cells carrying high endogenous FGF19, and significantly suppressed tumor growth in an orthotopic mouse model of HNSCC. This study demonstrates that FGF19 gene amplification corresponds with an increased dependency upon FGF19/FGFR4 autocrine signaling in HNSCC, revealing a therapeutic target for this cancer type. Note: This abstract was not presented at the meeting. Citation Format: Liwei Lang, Lixia Gao, Chloe Shay, Xiangdong Zhao, Austin Shull, Yong Teng. Essential role of autocrine FGF19-FGFR4 signaling in head and neck tumorigenesis [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 853.
53Altered CaMKII and ROS microdomains favor sparks in orphaned RyR after myocardial infarction
Authors: E Dries, I Lenaerts, N Macquaide, D Santiago, P Claus, KR Sipido
Journal: Cardiovascular Research (2014)

Purpose: In ventricular myocytes of rodents, ryanodine receptors (RyRs) are typically organized at Z-lines where the sarcoplasmic reticulum forms dyads with T-tubules (TTs). In large mammals, TT density is lower and not all RyRs are coupled to the TTs. Recently, we have shown that non-coupled RyRs lack a CaMKII and ROS-dependent microdomain modulation during rate adaptation. Here we examine how this microdomain modulation may be altered in ischemic cardiomyopathy where the fraction of non-coupled RyRs is increased. Methods: Using an established pig model of chronic ischemia and myocardial infarction (MI, N=7), we studied myocytes adjacent to the MI and compared these to myocytes from SHAM pigs (N=5) using whole-cell voltage clamp with Fluo-4 as a [Ca2+]i indicator and confocal line scan imaging. Spontaneous Ca2+ sparks were recorded during a 15s period following stimulation and assigned to different subcellular regions categorized as coupled or non-coupled RyR using a specific algorithm. All data were obtained in at least 3 different animals. Results: In myocytes from SHAM, we confirmed the specific modulation of coupled, but not of non-coupled, RyR as seen in control hearts, i.e. an increase of spark frequency at 2 Hz stimulation that is dependent on CaMKII and NOX2-generated ROS (#sparks/100 μm/s in SHAM: 0.8 ± 0.1 at 0.5 Hz to 2.3 ± 0.2 at 2 Hz, vs. 1.5 ± 0.2 with AIP at 2 Hz, and 1.1 ± 0.2 with gp91 ds-tat peptide at 2 Hz, p-value < 0.05 vs. control, n=7-14 in each group). In MI myocytes this modulation of coupled RyR was absent (#sparks/100 μm/s at 2 Hz not different from at 0.5 Hz and no effect of AIP and gp-91 ds-tat peptide). The fraction of non-coupled RyR was larger in MI (orphaned RyR) and their spark frequency at 2 Hz was significantly higher compared to SHAM. In contrast to SHAM, the response of these orphaned RyR was sensitive to CaMKII inhibition (AIP) (at 2 Hz #sparks/100 μm/s was 5.3 ± 0.5 at baseline vs. 3.1 ± 0.6 with AIP, p-value < 0.05, n=8-10 in each group). A significant reduction in spark frequency was observed in these orphaned RyRs after global ROS scavenging (NAC) (2 Hz #sparks/100 μm/s was 5.2 ± 0.5 at baseline vs. 2.9 ± 0.6 with NAC, p-value < 0.05, n=9-10 in each group) and after mitochondrial ROS inhibition using mitoTEMPO (at 2 Hz #sparks/100 μm/s was 2.9 ± 0.4 at baseline vs. 1.1 ± 0.3 with mitoTEMPO, p-value < 0.001, n=8 in each group) while NOX2 inhibition had no effect (gp91 ds-tat peptide, n=10–14). Conclusion: After MI there is a novel RyR microdomain organization favoring sparks in orphaned RyR, possibly related to mitochondrial ROS production.
Table of Contents
Authors: Aimee Two, Wiggin Wu, Richard Gallo, Tissa Hata, San Diego, Chelsea Cooper, Nicoleta Arva, Christina Lee, Oriol Ye´lamos, Roxana Obregon, Lauren Ba, Annette Sholl, Lisa Wagner, Joan Shen, Pedram Guitart, Pedram Gerami, Robert Cook, Maria Russell, Jeff Wilkinson, Rodabe Amaria, Rene Gonzalez, Stephen Lyle, Gilchrist Jackson, Anthony Greisinger, Clare Johnson, Kristen Oelschlager, John Stone, Derek Maetzold, Laura Ferris, Jeffrey Wayne, Keith Ba, David Delman, Chelsey Straight, Young Lee, Guodong Liu, Joslyn Kirby, ; Hershey, Kathryn Anderson, Steven Feldman, Winston-Salem North, Alexander Fogel, Sharleen Hill, Joyce Teng, Alexander Maley, Robert Swerlick, Douglas Parker, Benjamin Stoff, ; Atlanta, Jeffrey Cohen, M Husni, Abrar Qureshi, Joseph Merola, ; Boston, Jenna Peart, Carrie Kovarik, ; Philadelphia, Imran Amir, Kristen Foering, Jason Lee
Journal: Journal of the American Academy of Dermatology (2015)
THE TEXAS QUARANTINE.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Universal screening for tuberculosis infection. School's out!
Authors: J. R. Starke
Journal: JAMA (1995)

From 1984 to the present, the United States has experienced a well-publicized resurgence of tuberculosis. While the total number of tuberculosis cases in the United States increased almost 20% from 1985 to 1992, the 1707 cases in children younger than 15 years old in 1992 represented a 35% increase from case numbers in 1985.<sup>1</sup>From 1986 to 1993, the tuberculosis rate in foreign-born children was 27.7 cases per 100 000 person-years, which was 13.2 times greater than the rate among children born in the United States.<sup>2</sup>Pediatric tuberculosis is geographically focal. In 1989, only 11% of US counties reported a case of childhood tuberculosis, and six states-California, Texas, New York, Illinois, Florida, and New Jersey—reported over 70% of recent cases. See also page 613. Unfortunately, very little information is available concerning tuberculosis infection rates. The number of children in the United States infected with<i>Mycobacterium tuberculosis</i>is unknown