tbuckley/cabot-search huggingface dataset:
On the Cure of the Morphia Habit Without Suffering. With a Note on the Physiologic Method of Relieving the Craving for Drink.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Myotomie endoscopique (POEM) dans l’achalasie chez les patients naïfs de tout traitement comparée aux patients en échec des autres traitements
Journal: Endoscopy (2018)

La question posée de cette étude est celle de l’influence d’un traitement antérieur de l’achalasie sur l’efficacité de la POEM. Pour répondre à cette question, cette équipe Indienne a analysé rétrospectivement tous les patients ayant eu une POEM dans leur centre de janvier 2013 à novembre 2016, en les séparant en 2 groupes: le groupe “naïf” (de tout traitement) et le groupe “échec des traitements antérieurs” (prior treatment failure ou PTF). Les éléments de comparaison pris en compte étaient: le succès technique et clinique, les effets secondaires et le temps opératoire.
Marital and family therapy for troubled physicians and their families. A bridge over troubled waters
Authors: I. D. Glick
Journal: JAMA (1984)

Because individual therapy for troubled physicians has been notoriously difficult and often ineffective, we report our experience using a treatment—marital therapy—newly applied to such problems in the medical community. The sample involved 13 male physicians and their spouses with emotional difficulties in themselves and/or their relationships. After marital treatment, there was substantial improvement in more than 92% (12/13) of the physicians, their spouses, and/or their marital relationships. (<i>JAMA</i>1984;251:1855-1858)
Abstract 4245: Establishment of patients’ primary ovarian cancer xenograft models for test of anticancer agents
Authors: Changnian Liu, Yan Li, Tianfu Yue, Wenwei Li, Wen Zhou, Yong Liu, Fang He, Rui Zhou, Chang Bai
Journal: Cancer Research (2012)

Abstract BACKGROUND Human xenograft tumor models established by transplantation of human tumor cell lines into immunodifficient mice have been routinely used for preclinical test of anticancer agents. But tumor cell lines have a relatively low transplantability, which resulted in a limited number of tumor models available for test of novel anticancer agents. Recently, we have developed a large number of patients’ primary ovarian tumor xenograft models by transplanting human fresh ovarian tumor tissues into nude mice, which have been employed for preclinical test of clinically used drugs and novel anticancer agents for their chemosensitivity screening. METHODS The fresh ovarian tumor samples were collected from local hospitals. The tumor fragments of 2-3 mm were subcutaneously implanted in the flanks of nude mice by trocar needle. Sixteen tumor fragments were grafted into four mice from one patient tumor tissue (passage 1). The clinically used drugs included cisplatin, carboplatin, paclitaxel, and docetaxel. The histology and gene sequence of the established primary tumor models were analyzed and compared with patients’ original tumors. RESULTS A total of 76 patients’ ovarian tumor samples were implanted into nude mice; and 35 primary tumor models have been established with a tumor taking rates of 47% for the first passage. The tumor taking rates were higher in the later passages ranged from approximately 70-100%. The therapeutic efficacy of the test anticancer drugs was consistent with their clinical findings. The patients’ primary ovarian tumor xenografts from all 5 passages retained a similarity in architecture, histopathological morphology, and genomic mutation status to their patients’ original tumors. CONCLUSIONS The patient primary tumor model system can provide a larger number of models for selection of right models for preclinical testing novel agents based on their anticancer mechanism. The primary tumor models retain a similarity in histology and genomic mutation status to their patients’ original tumors. They may predict more relevant clinical response rate and higher correlation with clinical findings than use of traditional xenograft models established from long-term cultured cancer cell lines. Especially, they have advantages for test of target-oriented therapeutics in new drugs development programs. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4245. doi:1538-7445.AM2012-4245
HIV antibody testing among those at risk for infection. The National AIDS Behavioral Surveys
Authors: D. C. Berrios
Journal: JAMA (1993)

<h3>Objective.</h3> —To determine the prevalence of testing for human immunodeficiency virus (HIV) antibody among adults with various risk factors for infection, particularly those residing in large metropolitan areas where the bulk of cases of acquired immunodeficiency syndrome (AIDS) have occurred. <h3>Design.</h3> —A nationwide, population-based telephone survey eliciting testing, sexual, and injection drug use histories. <h3>Participants.</h3> —A total of 2673 randomly chosen US residents and 8263 randomly chosen residents of 23 metropolitan areas containing 64% of reported cases of AIDS. <h3>Interventions.</h3> —None. <h3>Main Outcome Measure.</h3> —Testing for HIV antibody. <h3>Main Results.</h3> —Overall, rates of individuals ever tested were only slightly higher in the urban areas (23%) than in the nation as a whole (21%). Testing frequencies were low among all risk groups (less than 40%), except men engaging in same-sex sexual activity (60%) and male and female injection drug users (46% and 73%, respectively). The low rate of testing (35%) among the largest risk group, heterosexual men and women engaging in unprotected sexual intercourse with multiple partners, was particularly worrisome. <h3>Conclusions.</h3> —To encourage antibody testing among the many at risk for infection who have not yet been tested, promotional campaigns should explain the universal susceptibility to infection among those at risk, and the availability of prophylactic medical therapies and social support services to persons who are HIV-seropositive. As there were comparable levels of risk-taking behavior among subjects in both samples, these campaigns must be designed to reach all segments of the population. (<i>JAMA</i>. 1993;270:1576-1580)
Course of Lectures on Venereal Affections Delivered at the Hopital Du Midi, Paris
Authors: P. Ricord
Journal: BMJ (1843)

Diagnosis-Simple absorption-Examination of sy- philitic patients-EBamination by speculum.GENTLEMEN,-The diagnosis of most diseases is attended with great difficulties; but in no branch of science are those difficulties so great as in general affections, wherein the surgeon has not only to
Deaths from Nine Chronic Diseases—United States, 1986
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PROFESSOR HORATIO C. WOOD.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Barrett’s esophagus
Authors: A. Rastogi, P. Sharma
Journal: Endoscopy (2006)

The last few decades have seen an appreciable rise in the incidence of esophageal adenocarcinoma in Western countries [1] [2] [3] [4]. The majority of esophageal cancers in the USA and Western Europe are now adenocarcinomas [2] [4]. The prognosis after a diagnosis of esophageal adenocarcinoma is generally poor, with the 5-year survival rate in patients with advanced disease being less than 20 % [5] [6]. Since Barrett’s esophagus is a recognized risk factor for esophageal adenocarcinoma, there has been a sustained research interest in this clinical entity. Several interesting abstracts on Barrett’s esophagus were presented at Digestive Disease Week (DDW) in Los Angeles this year.
Reading Epilepsy
Authors: Harold Stevens
Journal: New England Journal of Medicine (1957)

A WIDE variety of sensory or psychic experiences may presage or precipitate a convulsive seizure. The knowledge of this premonitory and sequential pattern of events that introduce the seizure often reveals the epileptogenic focus, and, in addition, it may permit precise classification of the convulsive syndrome. Therefore, thorough exploitation of the patient's history is particularly rewarding in the study of the epileptic patient.Primary reading epilepsy, a new syndrome delineated by Bickford and his co-workers,† is an example of this principle. It is diagnosed by the history of a generalized grand-mal seizure occurring only after reading. Fairly prolonged reading is . . .
Letters to the Editor
Authors: Karl H. Schütte
Journal: JNCI Journal of the National Cancer Institute (1969)

Journal Article Letters to the Editor Get access Karl H. Schütte Karl H. Schütte Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 43, Issue 2, August 1969, Pages iii–iv, https://doi.org/10.1093/jnci/43.2.iii Published: 01 August 1969
Circulating regulatory anti–T cell receptor antibodies in patients with myasthenia gravis
Authors: Florence Jambou, Wei Zhang, Monique Menestrier, Isabelle Klingel-Schmitt, Olivier Michel, Sophie Caillat-Zucman, Abderrahim Aissaoui, Ludovic Landemarre, Sonia Berrih-Aknin, Sylvia Cohen-Kaminsky
Journal: Journal of Clinical Investigation (2003)

Serum anti–T cell receptor (TCR) Ab's are involved in immune regulation directed against pathogenic T cells in experimental models of autoimmune diseases. Our identification of a dominant T cell population expressing the Vβ5.1 TCR gene (TCRBV5-1), which is responsible for the production of pathogenic anti-acetylcholine receptor (AChR) autoantibodies in HLA-DR3 patients with early-onset myasthenia gravis (EOMG), prompted us to explore the occurrence, reactivity, and regulatory role of anti-TCR Ab's in EOMG patients and disease controls with clearly defined other autoantibodies. In the absence of prior vaccination against the TCR, EOMG patients had elevated anti-Vβ5.1 Ab's of the IgG class. This increase was restricted largely to EOMG cases with HLA-DR3 and with less severe disease, and it predicted clinical improvement in follow-up studies. EOMG patient sera containing anti-TCR Ab's bound specifically the native TCR on intact Vβ5.1-expressing cells and specifically inhibited the proliferation and IFN-γ production of purified Vβ5.1-expressing cells to alloantigens in mixed lymphocyte reaction and the proliferation of a Vβ5.1-expressing T cell clone to an AChR peptide, indicating a regulatory function for these Ab's. This evidence of spontaneously active anti-Vβ5.1 Ab's in EOMG patients suggests dynamic protective immune regulation directed against the excess of pathogenic Vβ5.1-expressing T cells. Though not sufficient to prevent a chronic, exacerbated autoimmune process, it might be boosted using a TCR peptide as vaccine.
ESGE Newsletter
Journal: Endoscopy (2007)

The 15th United Gastroenterology Week in France attracted an overwhelming number of participants, and proved how keen the interest in discourse and knowledge exchange on gastroenterologic topics is on an international level. The lively interest in the live video sessions and all of the offerings in the ESGE Learning Area, especially the talks in the Lecture Theatre and the Hands-on-Training on Biologic Models, is rewarding evidence that the ESGE plays an active role in promoting good endoscopy in Europe.
RELIABLE DRUGS.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE ORIGIN OF SOME MILK CONSTITUENTS
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MANIFEST-2, a Global, Phase 3, Randomized, Double-Blind, Active-Control Study of CPI-0610 and Ruxolitinib Vs. Placebo and Ruxolitinib in JAK-Inhibitor-Naive Myelofibrosis Patients
Authors: John Mascarenhas, Claire Harrison, Katarina Luptakova, Jessica Christo, Jing Wang, Jennifer A Mertz, Gozde Colak, James Shao, Suresh Bobba, Patrick Trojer, Adrian Senderowicz, Jeffrey S Humphrey, Srdan Verstovsek
Journal: Blood (2020)
Massachusetts Medical Society
Authors: Edward P. Bagg
Journal: New England Journal of Medicine (1969)

A great medical leader — Dr. Edward Parsons Bagg, Jr. — died in his native Holyoke on May 9, 1969.Born on December 4, 1883, Dr. Bagg graduated from Yale University in 1907 and from Harvard Medical School in 1911. After an internship at the Massachusetts General Hospital he returned in 1913 to Holyoke, where he practiced his chosen specialty of pediatrics for more than 50 years. His competence and compassion inspired love and confidence in all who came under his care. He was chief of the Pediatric Service of the Skinner Clinic and chief of staff and of the . . .
Pancreatitis In Patients Treated With Brentuximab Vedotin: A Previously Unrecognized Serious Adverse Event
Authors: Mitul Gandhi, Andrew M Evens, Timothy S. Fenske, Paul Hamlin, Bertrand Coiffier, Andreas Engert, Alison J. Moskowitz, Nilanjan Ghosh, Adam M. Petrich, Jon Lomasney, Amy Chadburn, Gary S. Wood, Katrin Salva, Steven M Trifilio, Dennis W. Raisch, Dennis West, Leo I. Gordon, Jane N. Winter
Journal: Blood (2013)
Correction
Journal: BMJ (1958)

ANY QUESTIONS?Brucella Abortus in Milk Q.-What should be done when samples of tuberculintested, unpasteurized milk are foun7d to contain Brucella abortus ?A.-There is no obligation on local authorities to take any action when milk is shown to contain Br. abortus, although they are obliged to do so if the organism found is Br.melitensis: the usual course in that uncommon event is to prohibit marketing of the milk pending further investi- gation.A proceeding which safeguards the consumer, and should involve no hardship to producer or retailer, is to require that milk from the infected source be pasteurized.Investigations can then be made to trace the exact source of the infection.The "ring" test, an extremely simple test for Brucella agglutinin in milk, will serve to identify first the herd and then the individual animal(s) responsible.Final results may be verified by the whey agglutination test and culture or guinea-pig inoculation.If only one or two animals are affected, and the herd is a good one and well protected against reinfection, the elimination of these animals is in the farmer's interests as well as in those of the public health.
Trichinosis Encephalitis: Study of Electroencephalographic and Neuropsychiatric Abnormalities
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MEDICAL EDUCATION AND THE SUPPLY OF RURAL PHYSICIANS
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Rationing and the Americans with Disabilities Act
Authors: D. Orentlicher
Journal: JAMA (1994)

LAST year, when the Bush administration rejected Oregon's plan to ration medical care, it surprised observers with its reliance on the Americans With Disabilities Act (ADA) as the basis for the rejection.<sup>1</sup>When limitations in health care coverage have been challenged under other laws protecting the disabled, courts have not been sympathetic. In addition, in concluding that quality of life and functional status should not be taken into account at all in making rationing decisions,<sup>2</sup>the Bush administration called into question any serious attempts to ration health care (<i>Am Med News</i>. November 9, 1992:1). Nevertheless, there were problems with the Oregon plan. For example, there was unfair discrimination in Oregon's decision to deny liver transplants to rehabilitated patients with alcoholic liver disease but not to patients with other causes of liver failure.<sup>3</sup>Oregon modified its plan in response to the rejection and in response to further objections