tbuckley/cabot-search huggingface dataset:
Leave practice.
Authors: D Snadden
Journal: BMJ (1993)

General practice is changing: feelings about inadequate career structure and desires to develop professionally may well lead to greater career movement among general practitioners.The current situation, where general practice principal posts are seen as jobs for life, will change.This is already happening-Snowise found that 14% of newly appointed partners had already been principals in practice and that most advertised posts received applications from at least one established principal.'Trainees and retiring principals leave pratices every year, but little has been written about leaving patients, partners, and friends with sensitivity and minimal upset.Leaving practice, in any circumstances, is a difficult time for anyone, bringing emotional and practical challenges.Emotional difficulties, once recognised and accepted, can be helped by dealing with the practicalities of leaving in a way that ensures a smooth transition within the practice.This article is based on my recent leaving experience, a return visit to the practice some months later, and the reported experiences of other colleagues on their separation from practice.The return visit showed that the handover had gone very smoothly, with few problems being experienced by the practice.Careful preparation and attention to detail, particularly in giving accurate information to patients and staff, was crucial in achieving this.The parting was amicable, though it has to be admitted that not all partings are.The main themes of this article, particularly in terms of the process of preparing the practice and its staff and patients for a smooth changeover, apply even when partnerships dissolve in a climate of animosity.It could be argued that in such circumstances attention to the details described here becomes even more important in allowing new relationships to get off to a good start.
Psychiatry History
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Vesicocolonic Fistula
Authors: MOHAN MAKHIJA, MARVIN BRODIE
Journal: Clinical Nuclear Medicine (1985)

Gastrointestinal uptake on bone imaging has been described in entities such as necrotizing enterocolitis, metastatic calcifications, other causes of intestinal infarction, excretion in liver in pediatric patients, presence of free pertechnetate, and, rarely, in Milk-Alkali syndrome. Among the differential diagnosis and appearing similar to these lesions would be a fistula between the genitourinary tract and the gastrointestinal tract, and also an active gastrointestinal bleeding with hematogenous delivery of Tc-99m MDP to the bleeding site in the bowel. A case with a carcinoma of the bladder with fistulous communication between the bladder and the colon is presented.
Acute barbiturate intoxication. Concepts of management
Authors: J. Hadden
Journal: JAMA (1969)

Deep coma resulting from barbiturate overdose was studied in 50 patients. The length of coma correlated with depth of coma and serum barbiturate level except in those patients with drug addiction and hepatic or renal disease. The complications of pneumonia, bleeding of the gastrointestinal tract, urinary tract infections, and thrombophlebitis were common; however, all patients survived. Treatment was instituted on a rotation basis with supportive care alone, mannitol diuresis, or peritoneal dialysis. Using length of coma, the slope of disappearance of serum barbiturate value, and clearance data as indicators of the effectiveness of treatment, we found that the three treatment forms did not differ. Supportive care alone was associated with less local and systemic morbidity and appears to be the best method of reducing morbidity and mortality in patients with barbiturate overdose.
Corrigendum
Journal: BMJ (1936)

Mucous ColitisPERPLEXED " -writes: I have a female patient, aged 54 years, saffering from mucous colitis, which can be fairly well controlled by diet and occasional mediciine.But there are two symptoms which are entirely unaffected by any treatment so far given, either locally or generally.These are a p)ainful tongue, especially at the base, and a severe bitterness accompanving it.Practically everything taken by mouth aggravates both symptoms.I shall be grateful for any advice as to treatment."Calcium Phosphate Stomatitis" Dr. J. ST.CLAIR wNrites: A patieint of mine has been com- plaining for a considerable tine of very dry lips.This seems to be due to the condition of the mouth, which is hot and dry and coated with a grit-like fine sand.This " grit " can be taken betw-een the tecth anid " bitten."Collections of saliva-in the absence of dentures-reveal this " grit " in the form of a Xwhite deposit, consisting chiefly of calcium phosphate, with traces of calcium carbonate and organic matter.Various treatments have beein tried: pilocarpine, mouth-washes, glycerin smeared over the mouth and lips, and potassium acetate to act as a diuretic and prevent, if possible, the formation of calcium phosphate, but so far no success has attended our efforts.AIny suggestions as to the cause and cure of this conldition would be appreciated.Chromidrosis Dr. J. A. NOBLE (Lowtthorpe, Bournemoutlh) writes in reply to Dr. Gibb (Journal
Nonparenchymal cells from regenerating rat liver generate interleukin-1? and -1?: A mechanism of negative regulation of hepatocyte proliferation
Authors: R Boulton, A Woodman, D Calnan, C Selden, F Tam, H Hodgson
Journal: Hepatology (1997)

Following experimental partial hepatectomy of 70% in the rat, there is a semisynchronized surge of hepatocyte proliferation that ceases after 48 to 72 hours. Little is known about the determinants governing the termination of the proliferative phase, although transforming growth factor (TGF) β has been implicated as an important inhibitor of hepatocyte replication in this model. We previously reported an additional non-TGF-β inhibitor in medium conditioned by nonparenchymal cells isolated from regenerating liver (CM-NPC-Reg) between 24 and 48 hours after partial hepatectomy, but it was not found in medium conditioned by nonparenchymal cells from unoperated control liver. CM-NPC-Reg suppressed replicative DNA synthesis of primary rat hepatocytes in response to hepatocyte growth factor (HGF), epidermal growth factor (EGF), or TGF-α as assessed by 3H-thymidine incorporation. We now present evidence that interleukin (IL)-1 is the major inhibitor of hepatocyte DNA synthesis present in CM-NPC-Reg. IL-1 receptor antagonist abrogated the inhibition, as did antibodies to rat IL-1α and -β a combination of both antibodies was required, implicating both IL-1α and IL-1β as active constituents in CM- NPC-Reg. To investigate in vivo changes in IL-1 expression, we assessed expression of IL-1α messenger RNA (mRNA) in whole rat liver following partial hepatectomy; mRNA was down-regulated at 10 hours in the pre-replicative phase of liver regeneration and up-regulated at 24 hours and 48 hours when proliferation is waning. Rat hepatocytes isolated from liver 24 hours after partial hepatectomy showed increased sensitivity to the inhibitory action of IL-1. Exogenous IL-1β, administered parenterally to a group of rats at 0 and 12 hours after partial hepatectomy significantly reduced the incorporation of the thymidine analogue, bromodeoxyuridine (BrdU), into hepatocytes at 18 hours. These data indicate that nonparenchymal cells isolated from regenerating rat liver elaborate IL-1, and support the hypothesis that IL-1 plays a role suppressing hepatocyte proliferation and terminating the surge of DNA synthesis induced after partial hepatectomy.
How Are the Physical and Chemical Properties of Chrysotile Asbestos Altered by a 10-Year Residence in Water and up to 5 Days in Simulated Stomach Acid?
Authors: Krisna Seshan
Journal: Environmental Health Perspectives (1983)

Although there have been a number of studies on the ingestion of asbestos, few studies exist on how the chrysotile asbestos itself is altered by the exposure to the acid stomach environment. This study has found that there are changes in the physical, chemical and surface properties of chrysotile asbestos as a result of exposure to water, strong acids, and simulated gastric juices. It was observed that the charge on the surface (the zeta potential) is changed from positive to negative; the surface becomes silicalike; and the magnesium is lost from the fibers of asbestos upon exposure to water and acid. It was also noted that the smaller the fiber diameter, the faster the loss of the magnesium. Notable among the changes in physical properties is a change in the refractive index. This means that asbestos exposed to acids or water may not be detectable using the dispersion staining techniques that identify asbestos based on the refractive index. Other physical property changes include the destruction of the gross crystallinity of the fibers. The x-ray diffraction signal disappears when fibers are exposed to acid. However, this study shows that the fibers may still be detected by electron diffraction. It appears that upon acid exposure, the magnesium ions are leached out, leaving a magnesium-free silica network. A positive ion, possibly the proton (H+) or the hydronium ion (H3O+), replaces the lost magnesium ion.
Familial pheochromocytoma associated with cerebellar hemangioblastoma. A case history and review of the literature
Authors: S. G. Mulholland
Journal: JAMA (1969)

The association of pheochromocytoma with neurocutaneous diseases and tumors of neuroectodermal origin has recently been recognized. The case reported here provides evidence to suggest that there is more than a random relationship between pheochromocytoma and these tumors of the primitive ectodermal tissue. In addition to similar etiology and pathology, it is likely that a common origin may be postulated.
MODIFICATION OF GRAVITY METHOD OF ADMINISTERING ARSPHENAMIN
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TOBACCO AMBLYOPIA.
Authors: F. W. HIGGINS
Journal: JAMA (1897)

I shall make no attempt to present anything novel on the subject of tobacco amblyopia. It is a subject that has been much discussed during the thirty-three years since Jonathan Hutchinson first clearly connected failing vision with the inordinate use of tobacco. Still the pathology of the disease was not made clear until a dozen years ago and there is still much difference of opinion among writers upon the question of its real cause. But it is not even an attempt to clear up any one of these disputed points that I have had in mind in selecting this topic, but because I think that the ascertained facts in the case have been too much neglected by us as general practitioners. Until the ability to detect the condition is in the possession of the profession generally, it seems to me that many cases are bound to go unrecognized. Even if
J Albert Einstein Med Center, Philadelphia
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Radiologia, Panama
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Wound Check
Authors: Phillip J. Cozzi
Journal: Annals of Internal Medicine (1993)

Ad Libitum1 August 1993Wound CheckPhillip J. Cozzi, MDPhillip J. Cozzi, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-3-199308010-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Speaking only Russian, Gitlya Ulanovskyyells at me in such a way that I knowshe wants to go home. Ninety years old,Gitlya lives for phone calls from two nieces.Her hands are shapeless lumps of claythat tear the tape and gauze awayto bare her belly to my reach.Her stitches, bites of skin in each,are braids in clean-cut lines of flesh.This will not stop her. Nomisplaced loop of bowel will undonearly a century of conquest,revolution, pain and love,a thousand woundsa peasant's picnic in ... Author, Article, and Disclosure InformationAffiliations: Previousarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1993Volume 119, Issue 3Page: 245KeywordsChildren ePublished: 15 August 2000 Issue Published: 1 August 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Lithium-carbonate-induced myxedema
Authors: E. D. Luby
Journal: JAMA (1971)

After six months of lithium carbonate maintenance therapy, a myxedematous state was induced in a middle-aged manic-depressive man in whom results from basal thyroid function studies were found to be normal. The diagnosis was missed because it was assumed that his mental state and psychomotor retardation were manifestations of a shift to the depressive phase. The diagnosis of myxedema should be considered when a manic-depressive patient maintained with lithium carbonate develops sluggish mentation, apathy, and facial edema in the absence of the subjective experience of depression.
Thankfulness Unlimited
Authors: Thomas J. O'Donnell
Journal: JAMA (1972)

<h3>To the Editor.—</h3> In your excellent "Thanksgiving" EDITORIAL (<b>218</b>:1296, 1971), of 18 catastrophies that you mention, nine of them haven't happened yet. Shouldn't we be thankful for that? Of nine that have happened, four aren't really so bad. Housemaids are talking about detergents, but they could (and have) talked about worse; the Chicago Kennedy expressway is a mess, but then it always has been; the railroads are on strike, but they claim they operate at a deficit, so they must save money when they don't; and I know one airline pilot that doesn't really care what kind of work he is doing because he is so thankful for his wonderful parents. How's that for intelligence in the face of adversity!
Book Review Your Teeth: Their past, present and probable future . By Peter J. Brekhus, D.D.S. With a foreword by Irvine McQuarrie, Ph.D., M.D. 8°, cloth, 255 pp., with 20 illustrations, 31 plates and 7 tables. Minneapolis: The University of Minnesota Press, 1941. $2.50.
Journal: New England Journal of Medicine (1942)
Pulling the therapeutic rug
Authors: S. Vaisrub
Journal: JAMA (1978)

<i>Primum nil nocere</i>is a principle to be kept in mind not only when therapy is initiated, but also when it is terminated. There may be iatrogenic hazard in abrupt withdrawal of a drug. A recent example of such a hazard is the severe angina, myocardial infarction, and death that can occur in patients with coronary artery disease when therapy with propranolol is suddenly discontinued (<i>JAMA</i>237:53, 1977). Sudden discontinuance of therapy with propranolol may also precipitate acute thyrotoxicosis in persons whose hyperthyroid condition had been disguised by use of the drug. Shenkman et al<sup>1</sup>reported on three patients in whom florid clinical manifestations of hyperthyroidism on abrupt withdrawal of propranolol led to the unsuspected diagnosis. The threat of a superimposed acute thyrotoxic state to a heart already damaged by ischemic or hypertensive disease cannot be overemphasized. Equally florid, albeit more transient than the acute thyrotoxicosis of propranolol withdrawal,
Abstract 3235: Activation-inducible TNFR family receptor (AITR) signaling mediates the polarization of CD4+ T cells into Th1, Th2, and Th17, converts Treg to Teff and eradicates solid tumors
Authors: Byoung S. Kwon, Seung J. Lee, Young H. Kim, Joong W. Lee, Sun H. Hwang, Dass S. Vinay
Journal: Cancer Research (2019)

Abstract AITR (activation-inducible TNFR family receptor, human GITR), an inducible costimulatory receptor of human T cells, is expressed constitutively on Treg and inducible on Teff upon antigen engagement. AITR co-stimulates T cell activation and recruits certain members of TRAF family upon interaction with its ligand. We examined whether the stimulation of distinct regions of extracellular domain of AITR can generate signals that promote different subsets of CD4+ T cells. We found that crosslinking AITR by agonistic anti-AITR Abs (A27, A41, and A35), that recognize three distinct regions of the extracellular domain, polarize CD4+ T cells into Th1, Th2 and Th17, respectively. The subset polarization evoked by these antibodies was the result of recruitment of specific TRAFs, phosphorylation of distinct STATs and expression of Th subset fate-determining master regulatory genes. Stimulation with A27 recruited TRAF-1 and -2, activated STAT-1, -4 and JNK1/2, and induced transcription factor T-bet. On the other hand, activation with A35 recruited TRAF-6, activated STAT-3 and p38 MAPK, and induced RORγt. In contrast, A41 recruited TRAF-3 and -5, activated STAT-5, -6 and ERK1/2, and produced GATA-3. Remarkably, A27 induced the conversion of CD25+Foxp3+ Treg cells to IFN-γ-producing Th1 cells with a concomitant suppression of Foxp3 and TGF-β expression both in healthy individuals as well as cancer patients. A35 also, but not A41, suppressed the expression of Foxp3 and induced IL-17 in Treg cells. A27 alone, but not others produced a strong anti-tumor effect in a human tumor xenograft model of humanized mice in an IFN-γ- and Treg conversion-dependent mechanism. Taken together, the data that AITR regulates Th subset polarization and eradicates solid tumors can be a target for broad-spectrum immune check point therapeutics against cancers and autoimmune diseases. Citation Format: Byoung S. Kwon, Seung J. Lee, Young H. Kim, Joong W. Lee, Sun H. Hwang, Dass S. Vinay. Activation-inducible TNFR family receptor (AITR) signaling mediates the polarization of CD4+ T cells into Th1, Th2, and Th17, converts Treg to Teff and eradicates solid tumors [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3235.
AAMC Data Book: Statistical Information Related to Medical Education, January 1992
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal