tbuckley/cabot-search huggingface dataset:
Student Loan Deferment Heads AMA-RPS Interim Meeting Issues
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BROMIDE OF GOLD IN HYSTERIA.
Journal: JAMA (1890)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
From the Centers for Disease Control and Prevention. Hepatitis E among US travelers, 1989-1992
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Contents
Authors: D Fusco, R Chung, Nash Machado, H Cortez-Pinto, C Abe, H Hayes, T Ochi, M Maekawa, D Tsuge, F Miki, N Mitsui, M Hiraga, S Imamura, M Takahashi, Y Kubo, K Nakamura, E Girardi, P Scognamiglio, M Sciarrone, M Loffredo, C Gnesivo, P Noto, G Antonucci, M Capobianchi, G Ippolito, The Geas, B Bose, A Das, R Kumar, D Gondal, P Kumar, M Manns, M Bourlière, Y Benhamou, S Pol, M Bonacini, C Trepo, D Wright, T Berg, J Calleja, P White, J Stern, G Steinmann, C.-L Yong, G Kukolj, J Scherer, W Boecher, C Costentin, F Roudot-Thoraval, E.-S Zafrani, F Medkour, J.-M Pawlotsky, A Mallat, C Hézode
Journal: Journal of Hepatology (2011)
Nonmutagenic Carcinogens Induce Intrachromosomal Recombination in Dividing Yeast Cells
Authors: Robert H. Schiestl
Journal: Environmental Health Perspectives (1993)

A large number of animal and human carcinogens without apparent genotoxic activity exist (nonmutagenic carcinogens) that are difficult or impossible to detect with the currently used short-term tests.Because of the association of carcinogenesis with genome rearrangement, a system selecting for intrachromosomal recombination (DEL recombination) that results in genome rearrangement has been constructed in the yeast Saccharomyces cerevisiae.Because DEL recombination is under different genetic control than interchromosomal recombination and meiotic recombination, it is probably due to a different mechanism.It has been found that DEL recombination is readily inducible by 10 mutagenic carcinogens and 17 nonmutagenic car- cinogens that are not detectable (false negatives) with the Ames assay.In addition, three out of four mutagens that do not cause cancer (false positives in the Ames assay) do not induce DEL recombination.DEL recombination is inducible by UV only in dividing cells but not in cells synchronized in the G, or G2 phase of the cell cycle.Interchromosomal recombination, on the other hand, is inducible in GI but not in G2.The nonmutagenic carcinogens induce DEL recombina- tion only in actively growing cells, which may give some indication as to their mechanism.Further characterization of the mechanism involved in induction of DEL recombination may contribute to the understanding of the biological activity of nonmutagenic carcinogens.
Systemic light chain AL with cardiac and liver involvement can be predicted by transient elastography
Authors: Speranta Iacob, Andreea Jercan, Sorina Badelita, Camelia Dobrea, Ruxandra Jurcut, Monica Popescu, Mihaela Ghioca, Razvan Iacob, Liana Gheorghe, Daniel Coriu
Journal: Journal of Hepatology (2020)
Abstract 13785: Left Ventricular Contractile Entropy in 99mTc-Sestamibi SPECT is a Novel Prognostic Predictor in Patients with Non-ischemic Dilated Cardiomyopathy
Authors: Naoaki Kano, Takahiro Okumura, Akinori Sawamura, Naoki Watanabe, Hiroaki Mori, Kenji Fukaya, Ryota Morimoto, Akihiro Hirashiki, Yasuko Bando, Toyoaki Murohara
Journal: Circulation (2014)

Background: It has been reported that mechanical dispersion of myocardial contraction is increased in failing myocardium. However little is known about the association between contractile entropy evaluated by myocardial scintigraphy and prognosis in patients with non-ischemic dilated cardiomyopathy (NIDCM). Purpose: We aimed to investigate the prognostic value of contractile entropy in patients with NIDCM. Methods: Forty-seven patients (38 male, 55.1 years) with NIDCM were performed gated 99mTc-sestamibi myocardial perfusion SPECT (GMPS) and endomyocardial biopsy. Entropy was automatically calculated as a result of contractile phase analysis for each myocardial sampling point from GMPS, and it reflects a dispersion of global mechanical contraction. All patients were allocated into two groups based on the median of entropy; HE-group: entropy≥0.61 and LE-group: entropy&lt;0.61. All patients were followed up at the mean of 2.8 years. Results: The mean QRS duration, left ventricular ejection fraction (LVEF) and plasma brain natriuretic peptide (BNP) levels were 114 msec, 35% and 225 pg/mL, respectively. Although there were no significant differences in QRS duration and plasma BNP levels between the two groups, LVEF was lower in the HE-group than in the LE-group (31.1% vs 39.8%, p=0.002). In Kaplan-Meier survival analysis, cardiac event rate was significantly higher in the HE-group (Figure). Cox proportional hazard analysis revealed that the HE-group was a significant determinant of cardiac events (Hazard Ratio: 7.66; 95%CI: 0.070-2.532; p=0.033). The mRNA expression level of sarcoplasmic endoplasmic reticulum Ca2+ ATPase (SERCA2a) in biopsy specimens was significantly lower in the LE-group (p=0.015). Conclusion: Contractile entropy, reflecting an impairment of global left ventricular contraction, might be useful to predict a poor prognosis in patients with NIDCM.
Abortion
Authors: Lonny Myers
Journal: JAMA (1971)

<h3>To the Editor.—</h3> Since no ethical doctor would perform any medical procedure (abortion or any other), unless that procedure was intended to preserve or improve the mental or physical health of the patient, a recent Surpreme Court decision accepts abortion as an integral part of the practice of medicine. What sets abortion apart from other medical procedures is that abortion remains under the criminal code. This means that if the state can prove beyond reasonable doubt that the abortion was performed for reasons other than the mental or physical health of the patient, the doctor is guilty of a felony rather than malpractice. Since it is difficult to imagine an elective abortion not relieving the anxiety produced by an unwanted pregnancy, it would appear that physicians are now free to include abortion as an important resource in the treatment of problem pregnancies. The key is that the burden of proof
&lt;emph type="ital"&gt;Medical Economics&lt;/emph&gt;&lt;break /&gt; AN OPEN LETTER TO PRESIDENTIAL CANDIDATES
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
POLITICS AND CHARITABLE INSTITUTIONS.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bacterial meningitis in the United States, 1978 through 1981. The National Bacterial Meningitis Surveillance Study
Authors: W. F. Schlech
Journal: JAMA (1985)

From 1977 to 1981, 18,642 cases of bacterial meningitis were reported to the Centers for Disease Control. We analyzed data from 27 states with full participation from 1978 through 1981.<i>Hemophilus influenzae</i>was the most frequent cause of bacterial meningitis (48.3%), followed by<i>Neisseria meningitidis</i>(19.6%) and<i>Streptococcus pneumoniae</i>(13.3%). Overall attack rates for males were greater than for females (3.3 v 2.6 cases per 105 population per year). Attack rates were highest in children under 1 year of age (76.7 per 105 population per year). Case-fatality ratios were highest for gram-negative and miscellaneous causes of bacterial meningitis (33.7%) and lowest for meningitis caused by<i>H influenzae</i>(6.0%).<i>Neisseria meningitidis</i>and<i>S pneumoniae</i>meningitis occurred preponderantly during the winter, while<i>H influenzae</i>meningitis had peak activity in the spring and fall. Ampicillin resistance among<i>H influenzae</i>increased from 18.7% in 1978, to 23.9% in 1981. Serogroup<i>B Neisseria meningitidis</i>was the most common serogroup identified during the reporting period (51.1%), followed by serogroup C (22.3%), serogroup Y (5.8%), and serogroup A (4.7%) infections. (<i>JAMA</i>1985;253:1749-1754)
Small-Intestinal Pathology on Capsule Endoscopy: Spectrum of Vascular Lesions
Authors: M. Pennazio
Journal: Endoscopy (2005)

Corrected by: Small-Intestinal Pathology on Capsule Endoscopy: Spectrum of Vascular LesionsEndoscopy 2005; 37(10): 1029DOI: 10.1055/s-2005-870548
Characterization of Acute 4,4'-Methylene Dianiline Hepatotoxicity in the Rat
Authors: Marc B. Bailie, Thomas P. Mullaney, Robert A. Roth
Journal: Environmental Health Perspectives (1993)

Methylene dianiline (DDM) is a chemical intermediate in the production of isocyanates and other industrial chemicals, and it is hepatotoxic in humans. The acute hepatotoxicity of orally administered DDM was characterized in rats. Rats receiving DDM (25-225 mg/kg, per os) demonstrated a dose-dependent elevation in serum alanine aminotransferase activity, g-glutamyltransferase activity, and serum bilirubin concentration. DDM also caused a decrease in bile flow and an elevation in liver weight. Significant changes in these markers of liver injury occurred between 8 and 12 hr after a single, oral administration of DDM. Histologically, DDM caused multifocal, necrotizing hepatitis with neutrophil infiltration. Changes in the portal regions consisted of bile ductular necrosis, portal edema, neutrophil infiltration, mild fibrin exudation, and segmental necrotizing vasculitis. The role of cytochrome P450 monooxygenase (MO)-mediated metabolism in DDM hepatotoxicity was evaluated using the MO inhibitors, aminobenzotriazole and SKF-525A and the MO inducers phenobarbital and beta-naphthoflavone. Aminobenzotriazole provided protection from DDM-induced hepatotoxicity, whereas SKF-525A had no effect. The effect of phenobarbital pretreatment depended on the dose of DDM administered. At a dose of DDM that produced a maximal hepatotoxic response, phenobarbital did not influence hepatotoxicity. However, phenobarbital pretreatment provided protection against the hepatotoxic effects of a lower dose of DDM. beta-naphthoflavone pretreatment had a more modest effect on DDM-induced hepatic insult. These results demonstrate that DDM causes acute hepatotoxicity in the rat that is dose and time dependent. Results using inducers and inhibitors of MO suggest that DDM requires bioactivation to exert toxicity; however, the relationship between metabolism and toxicity may be complex.
Sun Exposure and Malignant Melanoma among Susceptible Individuals
Authors: Neil Dubin, Miriam Moseson, Bernard S. Pasternack
Journal: Environmental Health Perspectives (1989)

The purpose of this case-control study was to identify susceptible subgroups, primarily based on pigmentary characteristics, at higher risk of developing melanoma when exposed to the sun. The study group, which was interviewed from 1979 to 1982, consisted of 289 consecutive patients with melanoma and 527 randomly selected controls without cancer. In general, the risk of melanoma associated with sun exposure was greater for individuals expected to be susceptible on the basis of poor ability to tan, but not other pigmentary traits. There were, in addition, some noteworthy interactions between age and sun exposure. Among subjects with poor tanning ability, the risk of melanoma associated with outdoor occupation was more than 3-fold [odds ratio (OR) = 3.3] compared to indoor occupation. In contrast, the analogous OR was much less elevated among subjects with a good ability to tan (OR = 1.5). Mixed indoor and outdoor job exposure was protective among good tanners (OR = 0.80), but not among poor tanners (OR = 1.5). A similar pattern was seen for recreational sun exposure and, when applying multiple logistic regression, for the patient's overall subjective assessment of his lifetime sun exposure. However, quantitative assessment of average hours of sun exposure did not prove to be a good indicator of melanoma risk, even among susceptible individuals. A history of severe sunburn with blistering was associated with nearly 3-fold risk among poor tanners (OR = 2.9) but was protective among good tanners (OR = 0.79). A history of nonmelanoma skin cancer or solar keratosis was a very strong risk factor (OR = 7.3), which, however, did not significantly differ in magnitude among susceptibility subgroups.
Metal Transport in Cells: Cadmium Uptake by Rat Hepatocytes and Renal Cortical Epithelial Cells
Authors: Zahir A. Shaikh, Mark E. Blazka, Tetsuya Endo
Journal: Environmental Health Perspectives (1995)

The toxic metals appear to use the transport pathways that exist for biologically essential metals.In this regard interactions between the toxic and essential metals are possible.This report summarizes recent findings on the transport of cadmium in rat hepatocytes and renal cortical epithelial cells in the presence or absence of certain essential metals.The transport of cadmium in hepatocytes does not require energy and, therefore, is not an active process.It occurs primarily (80%) by temperature-sensitive processes, i.e., ion channels and carriers, that involve interaction with sulfhydryl groups.These processes apparently exist for the transport of essential metals like copper, zinc and calcium.The remaining 20% of the cadmium in hepatocytes is transported via a temperature-insensitive process, possibly by diffusion.In comparison with the hepatocytes, a smaller fraction (30%) of the cadmium transport through the basolateral membrane and none from the apical membrane of the renal cortical epithelial cells is temperature-sensitive.Total accumulation through the basolateral membrane is about twice that through the apical membrane.A majority of the cadmium transport in the renal cells is by diffusion.As in hepatocytes, copper, zinc and mercury antagonize cadmium transport through the apical membranes of the renal cells.The relative antagonism by copper is the same (25%); however, the antagonism by zinc (16%) and mercury (10%) is 4-to 6-fold lower than in hepatocytes.It appears that the relative contribution of various transport pathways available for cadmium uptake is different in each cell type and apparently depends on the morphological and functional differences between the cell membranes.-
Efficacy and Tolerability of CEP-18770 in Combination with Dexamethasone and Lenalidomide Using a SCID-Hu Model of Multiple Myeloma (MM)
Authors: Eric Sanchez, Cydney M Nichols, Alison C Lam, Mingjie Li, Jennifer Li, Cathy Wang, Colsen A Beveridge, Jacob T Lista, Haiming Chen, James R. Berenson
Journal: Blood (2011)
Dietary Patterns and the Risk for Type 2 Diabetes in U.S. Men
Journal: Annals of Internal Medicine (2002)

Summaries for Patients5 February 2002Dietary Patterns and the Risk for Type 2 Diabetes in U.S. MenSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-136-3-200202050-00003 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Type 2 diabetes mellitus, the most common form of diabetes, interferes with the body's ability to store foods, resulting in high blood levels of sugar. Over time, high blood sugar levels lead to complications such as blindness, kidney failure, and heart disease. Being overweight and physically inactive increases a person's chances of developing type 2 diabetes. Diet probably affects the risk for this disease, but it is difficult to separate the risk of diet from the risks of being overweight and inactive. Moreover, previous studies of diet and ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Dietary Patterns and Risk for Type 2 Diabetes Mellitus in U.S. Men.” It is in the 5 February 2002 issue of Annals of Internal Medicine (volume 136, pages 201-209). The authors are RM van Dam, EB Rimm, WC Willett, MJ Stampfer, and FB Hu.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoDietary Patterns and Risk for Type 2 Diabetes Mellitus in U.S. Men Rob M. van Dam , Eric B. Rimm , Walter C. Willett , Meir J. Stampfer , and Frank B. Hu Metrics Cited byWhat happens when you compare yourself to a model eating a cheeseburger? An experiment testing the impact of models promoting calorie-dense foods on beliefs about weight maintenance, body satisfaction, and purchase intent 5 February 2002Volume 136, Issue 3Page: I-30KeywordsCardiovascular therapyDietExerciseFoodMeatOverweightRenal diseasesRenal failureRisk managementType 2 diabetes ePublished: 5 February 2002 Issue Published: 5 February 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...