tbuckley/cabot-search huggingface dataset:
MEDICAL ADVERTISING.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Letter: Reporting deaths to the coroner.
Authors: J D Havard
Journal: BMJ (1974)

SIR,-The Brighton commnittee of inquiry into the death of Maria Colwell, keeping to its brief, has formulated an excellent report' which pinpoints deficiencies lin the co- ordination of agencies; but examination of the evidence shows that the lack of co- ordination was a subsidiary cause of the tragedy.The crucial decision to reimove thhe child from her affectionate foster-parents did not call 'for co-ordination between tihe agencies, nor did the decision by the court to support the return of the child to her natural parents.The second crucial decision, to leave the child in a situation of hazard, arose from the misinterpretation of albundant immediate data.Co-ordinating the informa- tion of other agencies was irrevelant.A
Alcoholic Ketoacidosis
Authors: Calvin L. Weisberger
Journal: JAMA (1971)

<h3>To the Editor.—</h3> We viewed with interest the case reports of Jenkins et al (<b>217</b>:177, 1971). We recently had a comparable experience. A 46-year-old Negro woman who was admitted to Thomas Jefferson University Hospital, Philadelphia, on July 5, 1971, after having indulged in many "scotches" late on July 3. She awakened on July 4 with mid-epigastric pain, and vomited eight times. This persisted until July 5, when she came to the hospital. There was no history of gastrointestinal disease, diabetes mellitus, or other metabolic disease. She had been in good health previously. Examination showed only some slight mid-epigastric tenderness, there were no stigmas of cirrhosis, and the liver to percussion was 8 cm in the right mid-clavicular line. Initial laboratory data showed a normal hemoglobin level and hematocrit reading, with 19,500 leukocytes and 90% neutrophils. Laboratory studies gave the following values: carbon dioxide, 8 mEq/liter; chloride, 96 mEq/liter; sodium,
Funder and Disclaimer Added
Authors: Katherine Rediger, D Miles, Seth Berkowitz, Jean Terranova, John Hsu, Cecil Sheps
Journal: JAMA Internal Medicine (2019)

In Reply We appreciate the thoughtful letter from Rediger and Miles regarding our study 1 and offer a few additional points.Given the importance of nutrition for health, we share the view that a broad range of nutrition options should be available to patients.In our view, medically tailored meal programs are one important tool that we hope becomes more widely available.Improving our knowledge regarding interventions to address food insecurity is an ongoing process, but we believe that implementation of existing interventions can cooccur with the further expansion of this evidence base.For example, Community Servings, in partnership with the Center for Health Law and Policy Innovation at Harvard Law School, is leading the development of a Food is Medicine State Plan in Massachusetts. 2 The goal of this plan is to not only address the nutritional needs of individuals through the health care system, but also to foster education, advocacy, and systems change regarding nutrition needs.An opportunity to help put this plan into action is coming in January 2020, when the Massachusetts Medicaid system will introduce financing mechanisms that allow for a broad array of beneficiary nutrition services, including medically tailored meals in appropriate circumstances.Nationwide, a major opportunity for similar work is that Medicare Advantage plans now have the ability to cover nutritional services via changes enacted in the Creating High-Quality Results and Outcomes Necessary to Improve Chronic Care Act. 3lthough meeting individual-level health-related social needs, such as food and nutrition, is a vital component of care, we also think it is important to view unmet health-related social needs as the end result of many social and environmental factors that affect health.Addressing these social determinants of health goes beyond clinical programs for individuals and requires collaboration among health care systems, public health systems, government, human services organizations, local communities, and families.Ultimately, we think it is critical not only to provide the appropriate services for those in need, but also to understand, and address, why health-related social needs arise.
PRECAUTION IN TONSILLECTOMY
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Critique and Cavil
Authors: George X. Trimble
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Heparin (1 U/ml) flushes of peripheral venous catheters prolongs their potency
Journal: BMJ (1998)

Colloids no better than crystalloids for fluid replacement in hypovolaemic patientsFor decades controversy has existed over the relative benefits of colloid and crystalloid solutions for fluid resuscitation of hypovolaemic patients.In their systematic review of randomised controlled trials Schierhout and Roberts (p 961) found that, compared with crystalloids, use of colloids was associated with an increase in absolute risk of mortality of 4%.There was no evidence for differences of effect among different types of injury necessitating fluid resuscitation.The authors conclude that there is no evidence to support the continued use of the more expensive colloids for acute volume replacement in critically ill patients.
Breast reconstruction
Authors: S Ahmed, A Snelling, M Bains, I H Whitworth
Journal: BMJ (2005)

One in nine women in the United Kingdom will develop breast cancer. 1 The surgical treatment of these patients will involve either breast conserving surgery or mastectomy, both of which can result in considerable asymmetry of the breasts.Breast reconstruction offers restoration of breast symmetry to such women, achieved by creating a breast mound that is similar in size, shape, contour, and position to the opposite breast.Women thus gain the freedom to wear a variety of clothing, without needing external breast prostheses, and have been shown to have less psychological morbidity than those who have mastectomy without reconstruction. 2ere we review the indications, timing, principles, and techniques of breast reconstruction in patients who need tumour ablative surgery.We concentrate predominantly on women who have had mastectomies. Sources and selection criteriaWe searched Medline and the Cochrane database search by using the term "breast reconstruction."We
Treatment of Acute Lymphoblastic Leukaemia: PRELIMINARY REPORT BY THE LEUKAEMIA COMMITTEE AND THE WORKING PARTY ON LEUKAEMIA IN CHILDHOOD
Authors: J Hutchison, R Hardisty, K Bagshawe, J Bridges, D Evans, D Galton, R Guyer, F Harris, C Howarth, E Innes, H Jones, P Jones, H Kay, D Mainwaring, J Martin, M Philpott, M Pike, L Sacker, W Schutt, J Stuart, E Thompson, M Till, M Willoughby, S Callender, G Fairley, F Hayhoe, M Israels, A Jacobs, G Mcdonald, C Newman, C Pengelly, D Weatherall, L Professor, N Ikoku, Miss Gilham
Journal: BMJ (1971)

One hundred and ninety-one cases of acute lymphoblastic leukaemia were entered in a trial in which, for five months, all received cytotoxic therapy with prednisolone, vincristine, mercaptopurine, L-asparaginase, and methotrexate (the latter in high dosage followed by folinic acid). Patients were then randomized to receive immunotherapy (B.C.G.), twice-weekly methotrexate, or no further treatment. One hundred and seventy-seven patients (93%) achieved full remission and at the time of analysis, 26 months from the beginning of the trial, 143 were still alive, including 70 in their first remission. Median “post-intensive” remission lengths were 17 weeks (no treatment), 27 weeks (B.C.G.), and 52 weeks (methotrexate). The prolongation of remission by methotrexate was most evident in those patients with low initial white cell counts. B.C.G. seemed to cause lymphocytosis but was without other conspicuous effect. The incidence of toxic reactions is reported, including an unusually low rate of anaphylaxis with L-asparaginase. These preliminary results are discussed and compared with those of similar trials.
The American Year-Book of Medicine and Surgery for 1903. A Yearly Digest of Scientific Progress and Authoritative Opinions in All Branches of Medicine and Surgery, Drawn from Journals, Monographs, and Text-Books of the Leading American and Foreign Authors and Investigators. Arranged, with Critical Editorial Comments, by Eminent American Specialists, Under the Editorial Charge of George M. Gould, A.M., M.D.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Deaths Associated With Hurricanes Marilyn and Opal—United States, September-October 1995
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A hard-shell temperature-controlling disposable blood oxygenator. Use in clinical open-heart surgery
Authors: R. A. DeWall
Journal: JAMA (1966)

A new blood oxygenator which comes presterilized and assembled has been used in open-heart surgery. Cooling and rewarming of the patient is efficiently maintained. Blood-flow rates exceeding 5 liters/min are easily managed by the oxygenator with an oxygenating gas to blood ratio of 2:1 to 4:1. The oxygenator functions with varying priming volumes as determined by the patient's size. Total priming of the apparatus is achieved with water electrolyte solutions. Successful clinical perfusions have lasted over 3 1/2 hours with every indication that appreciably longer perfusions would be possible. Perfusions with this apparatus are capable of maintaining normal metabolic states for prolonged periods. The total inhospital blood utilization including operating room and postoperative needs by these patients has averaged 4 liters.
Commentary
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Phase I study of a combination of S-1 and weekly paclitaxel in patients with advanced or recurrent gastric cancer
Authors: Y. Ueda, H. Yamagishi, D. Ichikawa, K. Koizumi, J. Morii, A. Takenaka, M. Shimotsuma, H. Kurioka, T. Yamashita, J. Sakamoto
Journal: Journal of Clinical Oncology (2004)

4222 Background: On the basis of our preliminary study of a combination of weekly paclitaxel (PTX) and DPD-inhibitory oral fluoropyrimidines (UFT, S-1) in advanced or recurrent gastric cancer (ARGC), we devised and started a phase I trial of a combination of S-1 and weekly PTX in ARGC. Objectives of the present trial were to examine dose-limiting toxicities (DLT) of this regimen, to determine the maximum-tolerated dose (MTD) and the recommended dose (RD) of PTX, and to evaluate the anti-tumor effect preliminarily. Methods: Eligibility included patients with histologically-proven ARGC, 20–75 years old, having a PS of 0–2, and having received no prior chemotherapy (except postoperative adjuvant therapies). S-1 was administered orally (80mg/m2/day) on 14 consecutive days (days 1–14), and TXL was infused (level 1: 60mg/m2, level 0: 50mg/m2) on days 1, 8, and 15. This course was repeated every 4 weeks. DLT were defined as grade 4 hematological (including grade 3 febrile neutropenia) and grade 3 non-hematological (except appetite loss, vomiting, and depilation) toxicities. Results: Fifteen patients were enrolled in the study (6 patients in level 1, and 9 patients in level 0). At level 1, 3 patients developed DLT (grade 4 neutropenia or grade 3 febrile neutropenia), which settled the MTD on this level. At level 0, only 2 patients developed DLT. Objective responses according to RECIST criteria were observed in 4 of 9 patients who had a measurable disease. Conclusions: The RD of PTX in this regimen was settled at 50mg/m2. A combination of S-1 and weekly PTX was well tolerated and suggested to produce worthwhile responses in ARGC. These results warrant further investigation, and a phase II study has already been started. No significant financial relationships to disclose.
New panel tackles clinical research funding cuts
Authors: C. Marwick
Journal: JAMA (1995)

AS COST-CONSCIOUS managed care organizations become the predominant force in the US health care system, the future of clinical research is in jeopardy. The academic medical centers that, since the 1960s, have provided the facilities for such research are coming under increased pressure to reduce costs. Clinical research, usually more expensive than patient care, is on the firing line. Deeply concerned about this situation, Harold Varmus, MD, director of the National Institutes of Health (NIH), convened an advisory panel of 14 experts to review the problems facing clinical research in the current cost-cutting environment and make recommendations for dealing with them. Chaired by David Nathan, MD, professor of pediatrics, Harvard Medical School, Boston, Mass, the panel met on the NIH campus in Bethesda, Md, last month. As might be expected from an NIH-appointed group, the benefits of clinical research were taken as given. Members agreed with, or at least voiced
Corticotropin-releasing factor-like immunoreactivity in senile dementia of the Alzheimer type. Reduced cortical and striatal concentrations
Authors: G. Bissette
Journal: JAMA (1985)

The concentration of corticotropin-releasing factor-like immunoreactivity (CRF-LI) in the human central nervous system was measured by radioimmunoassay in postmortem tissue of control patients and in those with histologically confirmed senile dementia of the Alzheimer type (SDAT). In the controls, CRF-LI was found in high concentrations in the hypothalamus and frontal cortex (Brodmann's area 10), in moderate concentrations in amygdala, substantia innominata, temporal and parietal cortex (Brodmann's areas 38 and 7), and the caudate nucleus, and in low concentrations in posterior hippocampus and nucleus accumbens. A marked reduction in the concentration of CRF-LI was observed in the frontal and temporal cortex (approximately 50%) as well as in the caudate nucleus (approximately 70%) in the SDAT group. The present findings suggest that neurons containing corticotropinreleasing factor are pathologically altered in SDAT, in addition to the previously described cholinergic and somatostatinergic neuronal degeneration. (<i>JAMA</i>1985;254:3067-3069)
PLURIGLANDULAR THERAPY
Authors: Abraham Zingher
Journal: JAMA (1925)

<h3>To the Editor:</h3> —A remark made by Prof. John J. Abel of the Johns Hopkins Medical School at the recent Congress of Physicians and Surgeons, while speaking on "General Considerations in Respect to the Hormones," is so good and so true and of such far-reaching importance that I cannot refrain from attempting to have it brought to the attention of the medical profession in this country and abroad through the columns ofThe Journal. I am quite certain that every physician will enjoy it and get his lesson from it as much as did the great gathering of representative medical men who came to Washington to hear some of the foremost authorities speak on the hormones of the body and the normal and abnormal functional activities of the glands of internal secretion. In commenting on the many shotgun preparations of the glands of internal secretion now so extensively exploited by