tbuckley/cabot-search huggingface dataset:
Prolonged Weakness and Vecuronium
Authors: Michio Hirano
Journal: Annals of Internal Medicine (1993)

Letters1 April 1993Prolonged Weakness and VecuroniumMichio Hirano, MD, Eric C. Raps, MD, and Jay Cowen, MDMichio Hirano, MDSearch for more papers by this author, Eric C. Raps, MDSearch for more papers by this author, and Jay Cowen, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-118-7-199304010-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:A growing body of literature describes prolonged weakness after concomitant administration of corticosteroids and nondepolarizing neuromuscular blocking drugs [1-4]. Most of these patients suffer from a severe myopathy. In our review [3], we found 33 patients with moderate to severe weakness, noted 4 days to 2 weeks after initiation of high-dose corticosteroids. Approximately 90% (30 of 33) of the patients were given nondepolarizing neuromuscular blocking agents (pancuronium or vecuronium). The serum creatine kinase level was often but not always elevated (10 of 16 patients). On nerve conduction studies and electromyography, 6 of 19 patients showed evidence of ...References1. Kupfer Y, Namba T, Kaldawi I, Tessler S. Prolonged weakness after long-term infusion of vecuronium bromide. Ann Intern Med. 1992; 117:484-6. Google Scholar2. MacFarlane I, Rosenthal F. Severe myopathy after status asthmaticus. Lancet. 1977; 2:615. Google Scholar3. Hirano M, Ott BR, Raps EC, Minetti C, Lennihan L, Libbey NP, et al. Acute quadriplegic myopathy: a complication of treatment with steroids, nondepolarizing blocking agents, or both. Neurology. 1992; 42:2032-7. Google Scholar4. Coursin DB. Neuromuscular blockade: should patients be relaxed in the ICU? Chest. 1992; 102:988-9. Google Scholar5. Segredo V, Caldwell JE, Matthay MA, Sharma ML, Gruenke LD, Miller RD. Persistent paralysis in critically ill patients after long-term administration of vecuronium. N Engl J Med. 1992; 327:524-8. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDiseases of the Peripheral Nervous SystemAcute Weakness Syndromes in Critically Ill Patients—A Reappraisal 1 April 1993Volume 118, Issue 7Page: 569-571KeywordsAction potentialsDrugsMetabolitesMuscle biopsiesMusclesMyosinsNervesNeuropathyParalysisRenal failure ePublished: 15 August 2000 Issue Published: 1 April 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Repeat Syphilis Cases Point to Need for Comprehensive Prevention
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ginkgo- tree dermatitis, stomatitis, and proctitis
Authors: L. E. Becker
Journal: JAMA (1975)

ALLERGENS causing skin sensitization also can result in allergic contact reactions of mucous membranes including cheilitis, stomatitis, proctitis, and pruritus ani. The present case illustrates an unusual cause of such allergy from the fruit of the female ginkgo tree. <h3>Report of a Case</h3> A 63-year-old man was observed in the Dermatology Clinic for porphyria cutaneatarda. His urinary uroporphyrins had decreased to 227μg/24 hr with abstinence from alcohol. During a scheduled return visit, perioral erythema and swelling were noted. The patient related a history of burning, tingling, and soreness of his mouth, and a thick feeling in his tongue which began that morning. He denied the ingestion of new foods, new toothpaste, chewing gum, or oral medications. Results of a physical examination showed perioral erythema, swollen lips, and erythema of the buccal mucosa, tongue, and tonsillar pillars. The patient was advised to change toothpaste, avoid chewing gum, gargle with salt water,
Endoscopy free papers 033-048
Authors: S Parry, J Barton, M Welfare, I Mohammed, L Cherkas, S Riley, T Spector, N Trudgill, S Lal, J Mclaughlin, G Giampaolo, G Dockray, A Varro, D Thompson, J Jones, D Kendall, P Millns, C Hawkey, S Dunlop, D Jenkins, R Spiller, L Gregory, L Yaguez, S Coen, E Amaro, S Smale, A Hobson, S Williams, Q Aziz, V Chudleigh, E Brennan, S Tarry, S Myers, S Lewis, G Smith, K Palmer
Journal: Gut (2002)

Introduction: Previous studies, many uncontrolled, suggest 4 to 32% of people develop irritable bowel syndrome (IBS) after ID.Little information is available on the development of other FGIDs after ID.Aim: To determine if patients with stool culture confirmed bacterial diarrhoea were more likely to develop gut symptoms consistent with a diagnosis of IBS, functional dyspepsia or functional diarrhoea at 3 and 6 month follow up compared with community controls.Methods: A prospective community-based case-control study over one year.Subjects with stool positive bacterial infectious diarrhoea and control subjects from the same primary care practice were invited to participate.The presence or not of IBS, functional dyspepsia or functional diarrhoea was diagnosed at the start and at follow up using self-complete Rome II modular questionnaires.The diagnosis of a baseline FGID excluded subjects from continuing.There were 128 cases and 219 community controls eligible and who consented to participate.Results: At follow up there was a higher incidence of FGIDs in the cases compared with controls, mainly due to a higher incidence of IBS (see table ).There was no difference in the incidence of functional dyspepsia between cases and controls.Conclusions: IBS and functional diarrhoea is diagnosed more frequently in people at three and six-month follow up after an episode of stool positive bacterial diarrhoea compared with community controls despite careful exclusion of people with pre-existing FGIDS and adds further support for the concept of post-infectious IBS.
Some recent events of special interest to medical education
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Relevance of Recertification for Primary Care Physicians
Authors: Edward J. Volpintesta
Journal: Annals of Internal Medicine (2008)

Letters1 July 2008Relevance of Recertification for Primary Care PhysiciansEdward J. Volpintesta, MDEdward J. Volpintesta, MDFrom Bethel, CT 06801.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-149-1-200807010-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Dr. Gonzalez's response confirms my belief about the shortcomings of the recertification process. Physicians' practices, particularly those of primary care physicians, become customized over time, and it is wrong for any board examination to rate them according to academic standards that are disconnected from the practical problems these physicians face every day.More important, the idea of failing a physician on a recertification examination is abhorrent and an affront to physicians' professionalism. Ideally, such examinations are meant to uncover areas of weakness and to recommend areas for remedial study. They are not meant to stigmatize physicians or impinge ... Author, Article, and Disclosure InformationAuthors: Edward J. Volpintesta, MDAffiliations: From Bethel, CT 06801.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoRelevance of Recertification for Primary Care Physicians Edward J. Volpintesta Relevance of Recertification for Primary Care Physicians Emilio B. Gonzalez Metrics 1 July 2008Volume 149, Issue 1 Page: 66-67 Keywords Conflicts of interest Primary care physicians ePublished: 1 July 2008 Issue Published: 1 July 2008 Copyright & PermissionsCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
<i>Helicobacter pylori</i> and Idiopathic Thrombocytopenic Purpura
Authors: Francesco Franceschi
Journal: Annals of Internal Medicine (2004)

Letters16 November 2004Helicobacter pylori and Idiopathic Thrombocytopenic PurpuraFrancesco Franceschi, MDFrancesco Franceschi, MDFrom Catholic University of Rome, 00168 Rome, Italy.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-141-10-200411160-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:In our previous study (1), in 1998, we described improved platelet count in patients with ITP after the eradication of H. pylori infection. A few months later, we investigated the prevalence of CagA-positive strains of H. pylori in the same patients and found that all patients were infected by those strains (2). None of the patients received steroids after eradication of H. pylori infection in 1998 because they maintained high platelet levels.We used the Dixon test in our previous study (1), and the disappearance of the antiplatelet antibodies was related to the negative results of this test ...References1. Gasbarrini A, Franceschi F, Tartaglione R, Landolfi R, Pola P, Gasbarrini G. Regression of autoimmune thrombocytopenia after eradication of Helicobacter pylori [Letter]. Lancet. 1998;352:878. [PMID: 9742983] CrossrefMedlineGoogle Scholar2. Franceschi F, Gasbarrini A, Tartaglione R, Sanz Totte E, Ojetti V, Candelli M, et al. Healing of autoimmune thrombocytopenia after H. pylori eradication: 1 year of follow up [Abstract]. Gastroenterology. 1999;116:G713. Google Scholar Author, Article, and Disclosure InformationAuthors: Francesco Franceschi, MDAffiliations: From Catholic University of Rome, 00168 Rome, Italy. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoHelicobacter pylori and Idiopathic Thrombocytopenic Purpura Francesco Franceschi , Nicholas Christodoulides , Michael H. Kroll , and Robert M. Genta Helicobacter pylori and Idiopathic Thrombocytopenic Purpura Giovanni Emilia , Mario Luppi , and Giuseppe Torelli Metrics Cited byH. pylori and platelet counts 16 November 2004Volume 141, Issue 10Page: 820KeywordsAntibodiesAntigensAntiplatelet antibodiesArteriesCellsHelicobacter pyloriHelicobacter pylori infectionIdiopathic thrombocytopenic purpuraPlateletsSteroids ePublished: 16 November 2004 Issue Published: 16 November 2004 Copyright & PermissionsCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
The Acquired Immune Deficiency Syndrome The Ever-Broadening Clinical Spectrum
Authors: Anthony S. Fauci
Journal: JAMA (1983)

The acquired immune deficiency syndrome (AIDS) is characterized by a severe and apparently irreversible acquired defect in cell-mediated immunity that predisposes the host to severe opportunistic infections and/or unusual neoplasms such as Kaposi's sarcoma.<sup>1</sup>It has attracted an extraordinary amount of attention, interest, and concern in the medical community as well as among the general public. Indeed, the concern is justified, since we are witnessing at the present time the evolution of a new disease process of unknown etiology with a mortality of at least 50% and possibly as high as 75% to 100% and with a doubling of the number of patients afflicted every six months. The disease was first believed to be confined to a particular epidemiologically defined segment of the population, ie, male homosexuals.<sup>2,3</sup>Earlier hypotheses suggested that there was something within the life-style of male homosexuals that predisposed them to this syndrome. Various theories
Unclear Statement
Journal: JAMA (2019)

This Adult Patient Develop Severe Alcohol Withdrawal?The Rational Clinical Examination Systematic Review," 1 published online and in the August 28, 2018, print issue of JAMA, the positive likelihood ratio under Laboratory Findings was incorrect.The sentence should read "A blood urea nitrogen of more than 26 mg/dL (to convert to millimoles per liter, multiply by 0.357) at admission (LR, 1.6 [95% CI, 0.67-3.88])was associated with an increased likelihood of developing delirium tremens in another study."This has been changed in Table 1 along with the sensitivity, specificity, and negative likelihood ratio, and in eTable 6, along with the case number, sample size, sensitivity, specificity, and negative likelihood ratio.Also, the version of the Prospective Validation Study of the Prediction of Alcohol Withdrawal Severity Scale (PAWSS) from the article by Maldonado et al 2 has replaced the earlier version used in Box 2 and eTable 7.This article was corrected online.
Ethmoid sinus cancer
Authors: N. M. Bleehen
Journal: JAMA (1972)

The ethmoid sinus is a collection of approximately nine air cells situated between the upper limit of the nasal fossa and the orbit and closely related to the posterio superior aspect of the maxillary antrum. Cancer in any of these regions may spread rapidly to the adjacent areas, especially as the early disease is frequently asymptomatic. Cancer involving the ethmoid sinus alone is therefore a rare entity, but is more usually part of an uncommon regional disease. A series of 715 tumors of the upper jaw collected by Lederman et al<sup>22</sup>over a period of 35 years included 176 cases of ethmoid cancer, ie, 25%. The basement membrane lining the sinus easily undergoes squamous metaplasia, and approximately 50% of the tumors are squamous cell carcinoma of varying degrees of differentiation, the majority of which are poorly differentiated. The remaining lesions include adenocarcinoma, lymphoma, Ringertz tumor, sarcoma, melanoma, and the
A President in shirtsleeves
Journal: Journal of the Royal Society of Medicine (2002)

The new President of the Royal Society of Medicine, Sir Barry Jackson, took office in mid-July 2002. A consultant surgeon at St Thomas’ Hospital for nearly thirty years, he is a longstanding Fellow of the Society—a member of the sections of Surgery, History of Medicine and Coloproctology (of which he became President) and serving on the Scientific and Executive Committee and the Council. Other presidencies have included the Association of Surgeons of Great Britain and Ireland and, most recently, the Royal College of Surgeons of England. He is an Honorary Consultant Surgeon to the Army and was formerly Surgeon to the Queen. He is interviewed here by Robin Fox.
Oral Medicine: Diagnosis and Treatment
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MEDICAL MEN IN THE CORONER'S OFFICE.
Journal: JAMA (1890)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CHRONIC SCURVY
Authors: ANNE WALKER
Journal: British Journal of Dermatology (1968)

SUMMARY— The clinical findings of long standing vitamin C deficiency in 7 patients are described. The outstanding features are a curious "woody" oedema of the legs associated with pain and discoloration and severe mental depression. These findings are contrasted with those seen in experimentally induced vitamin C deficiency in man. The difficulties of obtaining an accurate dietary history are emphasised. The suspected diagnosis should be confirmed biochemically.
Mature CD8+ T lymphocyte response to viral infection during fetal life
Authors: Arnaud Marchant, Victor Appay, Marianne van der Sande, Nicolas Dulphy, Corinne Liesnard, Michael Kidd, Steve Kaye, Olubukola Ojuola, Geraldine M.A. Gillespie, Ana L. Vargas Cuero, Vincenzo Cerundolo, Margaret Callan, Keith P.W.J. McAdam, Sarah L. Rowland-Jones, Catherine Donner, Andrew J. McMichael, Hilton Whittle
Journal: Journal of Clinical Investigation (2003)

Immunization of newborns against viral infections may be hampered by ineffective CD8+ T cell responses. To characterize the function of CD8+ T lymphocytes in early life, we studied newborns with congenital human cytomegalovirus (HCMV) infection. We demonstrate that HCMV infection in utero leads to the expansion and the differentiation of mature HCMV-specific CD8+ T cells, which have similar characteristics to those detected in adults. High frequencies of HCMV-specific CD8+ T cells were detected by ex vivo tetramer staining as early as after 28 weeks of gestation. During the acute phase of infection, these cells had an early differentiation phenotype (CD28–CD27+CD45RO+, perforinlow), and they acquired a late differentiation phenotype (CD28–CD27-CD45RA+, perforinhigh) during the course of the infection. The differentiated cells showed potent perforin-dependent cytolytic activity and produced antiviral cytokines. The finding of a mature and functional CD8+ T cell response to HCMV suggests that the machinery required to prime such responses is in place during fetal life and could be used to immunize newborns against viral pathogens.
International Teleradiology
Authors: Robert M. Wachter
Journal: New England Journal of Medicine (2006)

Interview with Dr. Robert Wachter on the outsourcing of medical services. (07:22)Download Imagine two patients arriving in the emergency department of a Maine hospital at midnight. The first has a presentation consistent with pulmonary embolism; the second, appendicitis. A decade ago, the first patient might have been started on heparin therapy and scheduled for an early-morning ventilation–perfusion scan. The second patient would have been seen by a surgeon, who would have made a judgment call regarding the diagnosis of appendicitis and the need for surgery.Today, both of these patients and hundreds of others like them would receive middle-of-the-night CT scans, taxing the hospital's radiologists. But midnight in Bangor, Maine, is 10:30 . . .
Applications of Monoclonal Antibodies to Neuroscience Research
Authors: K. Valentino
Journal: Annual Review of Neuroscience (1985)

The brain's default mode network consists of discrete, bilateral and symmetrical cortical areas, in the medial and lateral parietal, medial prefrontal, and medial and lateral temporal cortices of the human, nonhuman primate, cat, and rodent brains. Its ...Read More
Vesicoureteral reflux. A classification based on cause and the results of treatment
Authors: L. R. King
Journal: JAMA (1968)

Two hundred and forty-eight children were evaluated to ascertain the cause of vesicoureteral reflux. Bladder outlet obstruction was corrected when present. Ureteral reimplantation was performed when infection persisted, hydronephrosis worsened, or renal clearances deteriorated. Except in patients with neurogenic bladder and exstrophy, reflux ceased, improved or stabilized in 81%, without operation. When reflux was due to infection or occurred through a normal ureterovesical junction behind an obstruction, reimplantation was unnecessary. Reflux due to a short intravesical ureter usually stopped while a completely gaping orifice often required surgical revision. The more abnormal the ureteral orifice appears, the more likely it is that antireflux surgery will be required. Deterioration of renal function was occurring in spite of therapy in some of the 19% of refluxing renal units requiring reimplantation. It is not possible to successfully manage all patients with reflux without operation.