tbuckley/cabot-search huggingface dataset:
Abstract 5165: Secreted CCDC80 from hepatic stellate cells promote metastasis of hepatocellular carcinoma
Authors: Kwang-Suck Kim, SaeHwan Lee, Nayoung Jun, Hyog Young Kwon
Journal: Cancer Research (2019)

Abstract Liver cirrhosis is the most important risk factor for hepatocellular carcinoma (HCC) and hepatic stellate cell (HSC) has pivotal role in developing cirrhosis by producing various extracellular matrix (ECM). HSC are essential mediators of tumor microenvironment of HCC through remodeling of ECM and angiogenesis. We found that CCDC80 expression is upregulated in activated HSCs from RNA-sequencing with human fetal stellate cell. However, the role of CCDC80 was not well known in hepatocarcinogenesis. First, we validated mRNA expression of CCDC80 was increased in activated HSC lines and protein expression was also increased in cultured media. Functional analysis of knockdown and over expression CCDC80 was investigated in both HCC and HSC cell lines, and HCC cell lines were analyzed for proliferation (MTT assay), migration (using transwell), invasion (using Matrigel-coated transwell), and wound healing assay with condition media of CCDC80 knockdown HSCs. Expression of epithelial-mesenchymal transition (EMT) markers in HCC was evaluated with conditioned media. Knockdown of CCDC80 resulted in significantly reduced invasion, migration and wound healing behaviors of HCC cell lines. Overexpression of CCDC80 was increased invasion and migration. Expression of E-cadherin was increased and snail and vimentin expression were decreased in HCC cell lines cultured with conditioned media of CCDC80 knockdown HSCs. The associations between CCDC80 and EMT markers were validated in CCDC80 transfected HSC cell line compared with control. The mouse xenograft model also has shown the lower tumor growth, tumor weight and metastatic tumor nodule number in CCDC80 knockdown HSC with HCC co-injection compared with normal HSC and HCC co-injected mouse. Taken together, secreted CCDC80 from HSCs affected the aggressiveness and EMT of HCC cell lines. CCDC80 might be a novel biomarker and therapeutic target for patients with HCC. Citation Format: Kwang-Suck Kim, SaeHwan Lee, Nayoung Jun, Hyog Young Kwon. Secreted CCDC80 from hepatic stellate cells promote metastasis of hepatocellular carcinoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 5165.
Leçons cliniques sur le diabète.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
From the National Institutes of Health
Authors: Bernadine Healy
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Telecardiography and Use of Simple Computers
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Oral cephalosporins
Authors: C. M. Kunin
Journal: JAMA (1977)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Leads from the MMWR. Polysaccharide vaccine for prevention of Haemophilus influenzae type b disease
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AMA grams
Journal: JAMA (1974)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Rubella in pregnancy: a guide to rational counseling
Authors: V. A. Fulginiti
Journal: JAMA (1981)

In an article elsewhere in this issue (p 1647), Mann and colleagues have made an important addition to our ability to analyze and advise on the risk of congenital rubella after a possible exposure of a pregnant woman to an illnesswith rash. In one sense they are helping to ease the congestion of the national telephone lines, as many physicians in this dilemma call their favorite rubella experts (often at medical schools or at the Centers for Disease Control) for some help in estimating the probabilities of an adverse outcome. The method Mann et al have chosen is the preparation of three algorithms that speak to commonly encountered situations. The three algorithms deal with three periods between exposure to illness -with rash and the time of assessment—within one week, one to five weeks, and greater than five weeks—and the interpretation of the available standard laboratory test results. They also
Rectal injury during barium enema examination
Authors: C. L. Witte
Journal: JAMA (1983)

<h3>To the Editor.—</h3> In TOPICS IN RADIOLOGY (1982;248:1375), Walker and colleagues describe massive extravasation of extraperitoneal air in an elderly woman after double-contrast barium enema (DCBE) examination. Although the authors note a low reported incidence (0.02%) of rectal injury from DCBE examination and allude to wide variations in quantities of extraperitoneal and intraperitoneal air that may accumulate, they conspicuously underemphasize the potential lethality of this complication. Because these patients have fortuitously been thoroughly cleansed of stool by preexamination enemas and laxatives, such injuries may be treated expectantly. Nevertheless, as the following case report exemplifies, rectal tear from DCBE examination endangers life and may require prompt aggressive treatment. <h3>Report of a Case.—</h3> A 51-year-old asymptomatic woman underwent DCBE examination for follow-up of a benign polyp removed from the sigmoid colon three years earlier. Toward the end of the examination, the retention balloon suddenly ruptured, expelling the catheter. Although no immediate discomfort
EH1.1 Results of the interim analysis of the EORTC randomized phase III CATNON trial on concurrent and adjuvant temozolomide in anaplastic glioma without 1p/19q co-deletion, an intergroup trial
Authors: M. J. van den Bent, S. Erridge, M. Vogelbaum, A. Nowak, M. Sanson, A. A. Brandes, V. Golfinopoulos, T. Gorlia, J. M. Kros, B. G. Baumert
Journal: Neuro-Oncology (2016)
Pseudo-Sciences and Your Three Minds
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Analysis of Mouse LMIR5/CLM-7 as An Activating Receptor: Differential Regulation of LMIR5/CLM-7 in Mouse Versus Human Cells
Authors: Yoshinori Yamanishi, Jiro Kitaura, Kumi Izawa, Toshihiko Oki, Toshiyuki Takai, Toshio Kitamura
Journal: Blood (2008)
Ovarian dysfunction associated with an anticonvulsant drug
Authors: R. Cash
Journal: JAMA (1969)

Multiple endocrinopathies associated with the longterm administration of an anticonvulsant drug, aminoglutethimide (Elipten), were observed in a 19-year-old girl. The patient demonstrated minimal thyroid dysfunction with virilization as the major clinical manifestation of drug toxicity. Virilization was attributed to a disturbance in ovarian steroidogenesis. Evaluation of ovarian function should be undertaken in all women who continue to receive the drug for prolonged periods.
Reprint of: Nitric oxide-releasing polysaccharide derivative exhibits 8-log reduction against Escherichia coli, Acinetobacter baumannii and Staphylococcus aureus
Authors: Adoracion Pegalajar-Jurado, Kathryn A. Wold, Jessica M. Joslin, Bella H. Neufeld, Kristin A. Arabea, Lucas A. Suazo, Stephen L. McDaniel, Richard A. Bowen, Melissa M. Reynolds
Journal: Journal of Controlled Release (2015)
Reye's Syndrome and Salicylates
Authors: R. William Soller
Journal: JAMA (1987)

<h3>To the Editor.—</h3> A key aspect of the seven-year controversy concerning Reye's syndrome<sup>1,2</sup>has been the growing recognition of the importance of data sharing from publicly funded studies. Data sharing can be defined as the process whereby access to research data (eg, information in questionnaires and medical records) is granted by study investigators to outside parties for their scrutiny and analysis in order to assess the merits of the study—without unwarranted invasion of a study participant's privacy or interference with an investigator's freedom to publish. On this issue, the National Academy of Sciences Subcommitte on Sharing Research Data concluded that "sharing data should be a regular practice" and that "data relevant to public policy should be shared as quickly and widely as possible."<sup>3</sup>Department of Health and Human Services Under Secretary Don M. Newman stated in February 1987 that "we agree, in principle, that data sharing is important,
Aortic valve replacement in hemophilia. Report of a case
Authors: S. K. Brockman
Journal: JAMA (1972)

A patient with classical, severe hemophilia had his aortic valve replaced with use of extracorporeal circulation. To our knowledge, this is the first such patient who has undergone an open-heart operation. He was given enough antihemophilic factor (AHF) before, during, and after operation to effect normal hemostasis. The techniques for operation and extracorporeal circulation were not altered from the usual routine. The patient recovered from operation with disappearance of the left atrioventricular failure, incipient syncope, and angina that were present preoperatively. Four months after operation, the patient died following a massive, spontaneous intracerebral hemorrhage that was not related to the surgical procedure. We believe that open-heart operations can be performed safely in hemophiliac patients.
Mutagenic Metabolites of Benzene Detected in the Microscreen Assay
Authors: Toby G. Rossman, Catherine B. Klein, Carroll A. Snyder
Journal: Environmental Health Perspectives (1989)

The reactive metobolite responsible for benzene hematotoxicity and carcinogenicity is unknown.It can be hypothesized that the ultimate carcinogen derived from benzene metabolism might also act as a muta- gen.This laboratory has recently developed a new assay that can detect mutagens of all types, using a sin- gle strain of bacteria, E. coli WP2s (A), as a target.Different genetic end points can be monitored in the same exposed population of bacteria.When a number of known metabolites of benzene were assayed, only trans,trans-muconic acid gave a strong positive response.Mutations were induced at two genetic loci (Trp + revertants and T5 resistance).The mutagenic activity was greatly increased when a rat liver metabolizing system was added.We speculate that trans,trans-muconic acid is metabolized to a diepoxide, which may be the ultimate mutagen and possibly the ultimate carcinogen.
Erratum: Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemia
Authors: Daniel J Hodson, Michelle L Janas, Alison Galloway, Sarah E Bell, Simon Andrews, Cheuk M Li, Richard Pannell, Christian W Siebel, H Robson MacDonald, Kim De Keersmaecker, Adolfo A Ferrando, Gerald Grutz, Martin Turner
Journal: Nature Immunology (2010)
The Review Body's Award
Authors: D. G. Barrowcliffe, I. Ross-Smith, A. Sloane, K. M. King, C. C. B. Guest, J. B. Parkin, K. B. Jones, R. A. L. Smith, G. R. B. Whitaker, M. B. Collins, R. H. Mathews, A. O. Flint, J. S. McCarthy, W. W. Mathews, J. P. Thomson
Journal: BMJ (1965)
Synergism between allergens and viruses and risk of hospital admission with asthma: case-control study
Authors: Angela Huertas, Maaike Kruseman, Valdo Pezzoli, Finn Johnsen
Journal: BMJ (2002)

Our review indicates that there is no reliable evidence supporting the effectiveness of pedestrian education for preventing injuries in children and inconsistent evidence that it might improve their behaviour, attitudes, and knowledge.While the value of safety education of pedestrians remains in doubt, environmental modification and the enforcement of appropriate speed limits may be more effective strategies to protect children from road traffic. ConclusionsPedestrian safety education can improve children's knowledge of the road crossing task and can change observed road crossing behaviour, but whether this reduces the risk of pedestrian-motor vehicle collision is unknown.No trial focused on the other vulnerable road users, elderly pedestrians.None of the trials was conducted in low and middle income countries.
Contents
Authors: P Schirmacher, P Bedossa, T Roskams, D Tiniakos, E Brunt, J Zucman-Rossi, M Manns, P Galle, S Alter, S Jost, L Rihn, B Reyor, M Nolan, R Ghebremichael, M Bosch, G Altfeld, L Zhang, N Jilg, R.-X Shao, W Lin, D Fusco, H Zhao, K Goto, L Peng, W.-C Chen, R Chung, M Schneider, H Ledermann, C Saegesser, C Dorn, F Hellerbrand, L Chen, A Charrier, A Leask, S French, D Brigstock, Hepatectomy Miura, N Kimura, T Yamada, T Shimizu, N Nanashima, D Yamana, K Hakamada, S Tsuchida, T Nakano, Y.-F Cheng, C.-Y Lai, L.-W Hsu, Y.-C Chang, J.-Y Deng, Y.-Z Huang, H Honda, K.-D Chen, C.-C Wang, K.-W Chiu, B Jawan, H.-L Eng, S Goto, C.-L Chen, Coa Aires, A Van Cruchten, L Ijlst, I De Almeida, M Duran, R Wanders, M Silva, Steatohepatitis Lo, S Mclennan, P Williams, J Bonner, S Chowdhury, G Mccaughan, D Gorrell, S Yue
Journal: Journal of Hepatology (2011)
Advantages of peritoneal dialysis in chronic renal failure
Authors: A. Rae
Journal: JAMA (1973)

There are occasions when peritoneal dialysis is the appropriate treatment for patients with chronic renal failure. Some patients are best treated in this way permanently, and in others temporary treatment is indicated. In this study, an indwelling silicone rubber tube is used for this purpose in 34 patients. The procedure is simple and safe, and, apart from its benefit in the clinical situations outlined, it is of great value in relieving the congestion often found in chronic renal failure units.
Chronic Granulomatous Disease
Authors: Michael J. Chusid
Journal: JAMA (1975)

SURVIVAL beyond adolescence is unusual in chronic granulomatous disease of childhood because of a marked susceptibility to serious bacterial and fungal infection.<sup>1</sup>Therefore, diagnosis of this disease in patients older than 18 years of age is rarely reported.<sup>2,3</sup>Recently, we have diagnosed chronic granulomatous disease in a 27-year-old man suffering from atypical mycobacterial pneumonitis and osteomyelitis. <h3>Report of a Case</h3> A 27-year-old man was referred to the National Institutes of Health (NIH). He had had pneumonitis for two months, and his past history included a staphylococcal thigh abscess and several bouts of facial cellulitis. The patient's 12-year-old sister was known to have chronic granulomatous disease complicated by chronic<i>Nocardia</i>osteomyelitis, and a brother had died of disseminated tuberculosis at 1 year of age. Two months prior to referral, pleuritic chest pain developed with fever, night sweats, chills, and a 13.5-kg (30-lb) weight loss. A chest x-ray film showed
Man Shocks Wasp—For Heart Research
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal