tbuckley/cabot-search huggingface dataset:
To Emptiness
Authors: Donna Pucciani
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mobilization of Mercury and Arsenic in Humans by Sodium 2,3-Dimercapto-1-Propane Sulfonate (DMPS)
Authors: H. Vasken Aposhian
Journal: Environmental Health Perspectives (1998)

Sodium 2,3-dimercapto-1-propane sulfonate (DMPS, Dimaval) is a water-soluble chelating agent that can be given by mouth or systemically and has been used to treat metal intoxication since the 1960s in the former Soviet Union and since 1978 in Germany.To better approximate the body burdens of Hg and As in humans, DMPS-Hg and DMPS-As challenge tests have been developed.The tests involve collecting an overnight urine, administering 300 mg DMPS at zero time, collecting the urine from 0 to 6 hr, and determining the urinary Hg before and after DMPS is given.The challenge test, when applied to normal college student volunteers with and without amalgam restorations in their mouths, indicated that two-thirds of the Hg excreted in the urine after DMPS administration originated in their dental amalgams.In addition, there was a positive linear correlation between the amalgam score (a measure of amalgam surface) and urinary Hg after the challenge test.When the DMPS-Hg challenge test was used to study dental personnel occupationally exposed to Hg, the urinary excretion of Hg was 88, 49, and 35 times greater after DMPS administration than before administration in 10 dental technicians, 5 dentists, and 13 nondental personnel, respectively.DMPS also was used to measure the body burden of humans with a history of drinking water containing 600 pg As/liter.DMPS administration resulted in a tripling of the monomethylarsonic acid percentage and a halving of the dimethylarsinic acid percentage as related to total urinary As.Because South American animals studied were deficient in arsenite methytransferase, a hypothesis is presented that arsenite and arsenite methyltransferase may have had a role in the evolution of some South American animals.
Comparison of 2,17-Dimethyl Testosterone and Fluoxymesterone in Metastatic Breast Cancer
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Streptokinase still lysing coronary clots
Authors: P. Gunby
Journal: JAMA (1983)

While tissue-type plasminogen activator (t-PA) is the<i>big</i>news in thrombolytic therapy for an evolving myocardial infarction (MI), evaluation of streptokinase for the same purpose is<i>continuing</i>news (<i>JAMA</i>1981;245:689-694, 1982;248:805-811). In recent weeks, discussions at meetings sponsored by the Texas Heart Institute in Houston, the American College of Chest Physicians in Chicago, and the American Heart Association in Anaheim, Calif, have addressed these questions: How do results of streptokinase thrombolysis compare with results of other attempts to halt or limit an evolving MI? Should streptokinase be administered via an intracoronary or peripheral intravenous (IV) route? How soon should streptokinase be administered, and for how long, and what are the benefits in terms of survival and heart function? Part of the answer to the first question may come from an ongoing prospective study supported by the National Heart, Lung, and Blood Institute (NHLBI), Bethesda, Md. The study
THE PATHOLOGY OF SUNSTROKE.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Stevens' cure for tuberculosis
Authors: E Ernst
Journal: Journal of the Royal Society of Medicine (2002)

Stevens' cure for tuberculosis I was fascinated by Dr Newsom's account of Stevens' cure (September 2002 JRSM 1 ).In 1927 my father was apparently close to death in Talgarth TB sanatorium, South Wales, with severe bilateral lung disease and multiple haemoptyses.He was considered too ill for the thoracoplasty operation fashionable at the time.His father, himself dying of TB, had advised him on his deathbed to try Stevens' cure and at this stage of his illness he did.His recovery started from that date.He never had another haemoptysis and within 3-4 years was able to obtain life insurance and marry.The medical examiner was said to have flung down his stethoscope in amazement, declaring 'no sign of disease at all'.My father continued to take the umckaloabo root on and off for years but never had another attack.The distinctive pungent odour of what seemed to be an infusion would often fill the house and signal that Dad was not feeling too good for some reason.He worked as a chemistry teacher till he was 65 with never a day 'off sick' and died of heart failure at 77.When I went to Oxford to read medicine in 1958 I was found, to my surprise, to be Mantoux-test negative.My father, who possessed a lot of newspaper articles and one of the books on Stevens' cure, thought the BMA had been very unfair to Stevens (a non-medic) and very unscientific in their approach to a much needed avenue of possible TB research.Perhaps today, with the widespread resistance to TB drugs, the root should be properly evaluated.
OBITUARY.
Journal: JAMA (1889)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE ANTIVIVISECTION BILL AGAIN.
Journal: JAMA (1900)

The Senate Committee on the District of Columbia will hear arguments for and against the Gallinger antivivisection bill on some day in February, the exact date not given. We may assume it as certain that the zoöphiles will be there in force, with all the documentary support they can command, to reinforce their personal efforts. It is not too late to ask all physicians, medical societies and organizations that have not yet spoken to exert their influence by resolutions, memorials and direct individual work against the bill. Its possibilities for evil have been well pointed out in the medical press, but it is essential that the committee be collectively and individually enlightened. Whoever, therefore, like Dr. R. T. Morris, whose communication has already been noticed inThe Journal, can give his personal testimony as to the value of animal experiments should do so at once. Society resolutions and memorials are
Abstract 1586: CCL18 signaling from breast tumor-associated macrophages fosters the activation of fibroblasts into a chemoresistance-inducing phenotype
Authors: Xiaoqian Zhang, Jianing Chen, Shicheng Su, Erwei Song
Journal: Cancer Research (2020)

Abstract Carcinoma-associated fibroblasts (CAFs) are abundant and heterogeneous stromal cells in tumor microenvironment critically involved in cancer progression. Our recent study identified a specific CAFs subset by two cell-surface molecules, CD10 and GPR77. We proved that CD10+GPR77+ CAFs could promote tumor formation and chemoresistance by providing a survival niche for cancer stem cells (CSCs). However, their origin and underlying activating initiation mechanism are unclear. Tumor-associated macrophages (TAMs) are the most abundant immune-related stromal cells and the important source of inflammatory cytokine. Here, we demonstrated that CCL18 secreted by TAMs could induces the activation of normal breast fibroblasts into a CD10+GPR77+ CAFs phenotype, which are not only resistant to chemotherapy themselves, but also can induce chemoresistance in cancer cells by abundantly producing IL-8 and IL-6 and enriching the population of cancer stem cells. In conclusion, our studies have identified an inflammatory signaling network in the interaction of different kind of stroma cells in tumor microenvironment and highlighted its potential values as predictive markers and therapeutic targets to abrogate tumor formation and improve chemotherapeutic efficacy. Citation Format: Xiaoqian Zhang, Jianing Chen, Shicheng Su, Erwei Song. CCL18 signaling from breast tumor-associated macrophages fosters the activation of fibroblasts into a chemoresistance-inducing phenotype [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 1586.
Psychiatric Services to a Sustained Social Protest Campaign: An On-Site, Walk-In Clinic at Resurrection City
Journal: American Journal of Psychiatry (1969)

The walk-in mental health clinic described here provided brief, supportive treatment for participants in the Poor People's Campaign who were referred by the general medical staff or sought such help on their own. Although the mental health team members were confronted with some disturbing challenges arising from the unique social context in which the clinic operated, they report that the clinical program seemed useful to the campaign and provided a valuable experience for the participating professionals. Included in this report are several recommendations pertaining to the provision of similar services for future social action programs.
Cardiology
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
RHODOPSIN
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Environmentally Induced Autoimmune Diseases: Potential Mechanisms
Authors: Tharaknath Rao, Bruce Richardson
Journal: Environmental Health Perspectives (1999)

Environmental and other xenobiotic agents can cause autoimmunity.Examples include drug-induced lupus, toxic oil syndrome, and contaminated L-tryptophan ingestion.Numerous mechanisms, based on in vitro evidence and animal models, have been proposed to explain how xenobiotics induce or accelerate autoimmunity.The majority of these can be divided into three general categories.The first is those inhibiting the processes involved in establishing tolerance by deletion.Inhibiting deletion can result in the release of newly generated autoreactive cells into the periphery.The second mechanism is the modification of gene expression in the cells participating in the immune response, permitting lymphocytes to respond to signals normally insufficient to initiate a response or allowing the antigen-presenting cells to abnormally stimulate a response.Abnormal gene expression can thus disrupt tolerance maintained by suppression or anergy, permitting activation of autoreactive cells.The third is the modification of self-molecules such that they are recognized by the immune system as foreign.Examples illustrating these concepts are presented, and related mechanisms that have the potential to similarly affect the immune system are noted.Some mechanisms appear to be common to a variety of agents, and different mechanisms appear to produce similar diseases.However, evidence that any of these mechanisms are actually responsible for xenobiotic-induced human autoimmune disease is still largely lacking, and the potential for numerous and as yet unidentified mechanisms also exists.
Ginkgo and Memory
Authors: P. Murali Doraiswamy, Nunzio Pomara
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reports to the Membership
Authors: Maria Oquendo
Journal: American Journal of Psychiatry (2014)

A majority vote (.50%) is necessary in a three-way contest.If a majority does not exist after tallying all first-choice votes, voters' second-choice votes for the candidate with the least amount of first-choice votes are tallied and added to the remaining candidates' tallies.This follows the procedure for "preferential voting" outlined in Sturgis' The Standard Code of Parliamentary Procedure.
Detection of early arteriosclerosis by external pulse recording
Authors: D. Cooper
Journal: JAMA (1967)

Measurement, during reactive hyperemia, of the systolic slope of the pulse rate as recorded from a pneumatic cuff applied to the calf, appears to differentiate sharply normal subjects from arteriosclerotic subjects. There is slight overlap between the two groups for systolic slope at the foot and for mean pulse deflection at either level. Characteristic low values for systolic slope were obtained in all the arteriosclerotic subjects with symptomatic occlusion, and in limbs labeled as "normal" as opposed to "unilateral" disease. The test appears to depend upon arterial constriction or rigidity, with or without a pressure gradient, and should thus be more sensitive for identifying early disease than tests based upon pressure changes alone. This simple method is proposed for the epidemiological evaluation of arteriosclerosis. Its validity in predicting symptomatic disease will require further prospective studies.
Abstract 2822: Imaging of the Propagation of the Contraction Wave Using RF-Based Speckle Tracking In Vivo
Authors: Elisa E Konofagou, Jianwen Luo, Deepak Saluja, Kana Fujikura, Daniel Cervantes, James Coromilas
Journal: Circulation (2007)

OBJECTIVE : Using a combination of high-frequency ultrasonography, ECG gating, and RF-based motion estimation, our laboratory has developed a novel technique for the noninvasive mapping of contraction waves in the intact murine left ventricle. In this study, we sought to measure the velocity and direction of contraction waves in the murine heart during native conduction and pacing. METHODS : Twelve wild-type mice were anesthetized with IP pentobarbital, and an octapolar pacing catheter introduced into the right ventricle (RV) through the external jugular vein. In vivo ultrasound RF frames (30 MHz) were acquired at 8000 fps (Vevo 770, Visualsonics, Inc.), using ECG gating. Axial frame-to-frame motion were estimated using a speckle tracking method. Images were obtained in the parasternal long axis view under three conditions; sinus rhythm (SR), right atrial (RA) pacing, and RV pacing. Contraction was analyzed using ciné-loop images. RESULTS : Distinct contraction patterns were noted during isovolumic contraction (IC) ejection under all conditions. In SR, during IC, convergent motion of the septal wall (SW) and posterior wall (PW) began during the latter half of the QRS at the apex and spread basally, causing divergent movement at the base. At the onset of ejection, medial contraction spread to the base. Similar results were obtained with RA pacing. During RV pacing, the IC phase began with convergent motion of the basal SW and PW that spread apically, causing divergent motion of the apical SW and PW. During ejection, convergent motion of the apical SW and PW developed which spread to the basal SW and PW. This difference between SR/RA pacing and RV pacing was found in all mice (n=12). We found a significantly slower contraction wave velocity during RV pacing (0.5213 +/- 0.3125 m/s) than during SR/RA pacing (0.8496 ± 0.2214 and 0.8379 ± 0.1967 m/s, respectively) (p&lt;0.01), in line with previously reported results. CONCLUSION : This study demonstrates the ability of this modality to noninvasively map the velocity and direction of contraction waves. Using this technique, we demonstrate the difference in motion patterns between native conduction and ventricular pacing. This technique has potential applications in the noninvasive assessment of ventricular dyssynchrony.