tbuckley/cabot-search huggingface dataset:
Editorial Board
Authors: Cezmi Akdis, Zuhair Ballas, Iowa City, Iowa Deputy Editor, Stanley Szefler, Colo Associate, Andrea Apter, Leonard Philadelphia, St Bacharier, Claus Louis, Joshua Boyce, Robert Bush, Javier Chinen, Raif Geha, Kyoto Japan, Carole Ober, David Peden, Chapel Hill, Harald Renz, Marburg Germany, Marc Rothenberg, Cincinnati Ohio, Hirohisa Saito, Robert Wood, In-Chief Donald, Y Leung, Jonathan Bernstein, Diane Gold, Stacie Jones, Rachel Miller, New York, Joshua Milner, Chaim Roifman, John Steinke, Stephan Weidinger, Amos Etzioni, James Gern, Robert Hamilton, Paul Bryce, Mariana Castells, Mitchell Grayson, Bruce Mazer, Ariel Munitz, Kari Nadeau, Bruce Bender, Pascal Chanez, Morton Cowan, San Francisco, Elizabeth Matsui
Journal: Journal of Allergy and Clinical Immunology (2016)
Relapsing polychondritis with glomerulonephritis. Improvement with prednisone and cyclophosphamide
Authors: J. L. Ruhlen
Journal: JAMA (1981)

A 32-year-old man presented with relapsing polychondritis (RP) and microhematuria. A renal biopsy specimen disclosed focal segmental glomerulonephritis with occasional crescents. Immunofluorescent and electron micrographic studies suggested immune complex—mediated glomerular injury. Initially, life-threatening upper airway obstruction responded to high-dose corticosteroid therapy. Subsequently, progressive renal insufficiency and proteinuria caused by increasingly active glomerulonephritis were treated by adding cyclophosphamide, with sustained improvement. This case supports the concept that RP is an immunologically mediated disease and suggests that a regimen of prednisone and cyclophosphamide warrants consideration for use in cases of RP with glomerulonephritis. (<i>JAMA</i>1981;245:847-848)
Abstract LB-124: COP1 E3 ligase modulates response to oncogenic MAPK pathway inhibition
Authors: Manasi K. Mayekar, Trever Bivona
Journal: Cancer Research (2017)

Abstract Oncogenic activation of the RAS-MAPK pathway is the underlying cause of the majority of lung adenocarcinomas. In these tumors, RAS-MAPK pathway activation occurs via diverse genetic alterations in upstream receptor tyrosine kinases such as EGFR and ALK as well as in RAS, BRAF, MEK and RAS GTPase activating protein (GAP) and tumor suppressor, NF1. Therapies targeting components of the RAS-MAPK pathway can lead to initial tumor responses in many patients. But most patients show only a partial response and many do not respond at all despite the presence of a RAS-MAPK pathway-activating genetic lesion in the tumor. Hence, it is critical to understand the molecular basis of response and resistance to targeted therapies acting against the RAS-MAPK pathway in lung adenocarcinomas in order to improve patient survival. We conducted a genetic screen to identify modifiers of response to MAPK pathway inhibition in lung cancer. Our genetic screen uncovered the E3 ubiquitin ligase COP1/RFWD2 as a novel genetic modifier. We found that depletion of COP1 and members of its complex, as well proteasomal subunits, confers resistance to RAS-MAPK pathway inhibition in human lung adenocarcinoma cells with oncogenically-activated MAPK pathway. Since two critical MAPK pathway effectors c-Jun and ETV1 have been shown to be targets of COP1 E3 ligase complex-mediated proteosomal degradation, we tested if depletion of COP1 alters the levels of phosphorylated c-Jun and ETV1. Intriguingly, we did not observe a substantial impact of COP1 depletion on the levels of these effectors. Based on these observations, we hypothesize that depletion of COP1 confers resistance to MAPK pathway inhibition in RAS-MAPK pathway driven lung adenocarcinomas through accumulation of a novel protein substrate(s) that allows the survival and/or proliferation of these cells upon MAPK pathway inhibition. We will uncover the mechanism of resistance by identifying this substrate(s) of COP1 whose accumulation facilitates cell survival and/or proliferation upon MAPK pathway inhibition. This work will improve our understanding of the molecular basis of tumor cell resilience during initial treatment as well as of primary treatment resistance. Additionally, it could lead to identification of a novel biomarker for predicting response to MAPK pathway inhibitor therapy and a therapeutic target(s) that could be co-targeted with MAPK pathway signaling to improve the patient response in MAPK pathway driven lung adenocarcinomas. Citation Format: Manasi K. Mayekar, Trever Bivona. COP1 E3 ligase modulates response to oncogenic MAPK pathway inhibition [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr LB-124. doi:10.1158/1538-7445.AM2017-LB-124
Tumors, Innocent and Malignant. Their Clinical Character and Appropriate Treatment.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
影响白癜风患者生活质量的因素:全国性研究
Authors: J.M. Bae, S.C. Lee, T.H. Kim, S.D. Yeom, J.H. Shin, W.J. Lee, M.‐H. Lee, A.‐Y. Lee, K.H. Kim, M.B. Kim, C.J. Park, S.H. Lee, D.H. Kim, H.J. Lee, D.Y. Lee, C.W. Choi, Y.C. Kim, H.Y. Kang, S. Haw, Y.B. Lee, S.J. Yun, S.‐K. Yun, S.P. Hong, Y. Lee, H.J. Kim, G.S. Choi
Journal: British Journal of Dermatology (2018)

白癜风发病部位的皮肤会脱色并变成全白。这些白色部位往往形状不规则,如同地图上的岛屿,与周围正常皮肤对比明显,在天生肤色深(棕色或黑色皮肤)的人群或有古铜肌的白种人中非常明显。白癜风患者会变得非常局促不安且沉默寡言,不愿意出门或见人。因此,日常生活质量大打折扣。白癜风发病率为 0.5% 至 2%,且治疗效果不是很理想。这项在韩国开展的研究分析了哪些与白癜风有关的因素对患者生活质量的影响最大。此项大规模研究涉及 21 家不同医院的 1,100 多个成年患者。这些患者填写了详细的 Skindex‐29 问卷,且研究组成员检查了患者的皮肤。根据问卷结果,患者最关心的是白癜风是否会恶化,以及是否属于严重疾病。患者还关心亲人对此的感受,且超过一半的患者对于自身状况感到沮丧。身体上如果有大面积或者他人容易看到的部位出现白癜风症状,尤其影响生活质量。白癜风远不止是仪容问题,虽然白癜风部位通常可盖住,但超过三分之一的患者在情绪上也受到影响。
Research Quarterly, Washington
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Practical Anaesthetics for the Student and General Practitioner.
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Intrauterine Injections
Authors: J. Whitehead
Journal: BMJ (1873)

treated, with skill and judgment, a subject in pathology of considerable importance.Chronic endometritis, with uterine catarrh, is by no means of uncommon occurrence, and is a frequent cause of a distressing form. of dysmenorrhoea, as well as of sterility, especially in early married life, but also at a later age.Somewhat more than twenty-seven years ago a case occurred to me illustrative of some of the inconveniences which Dr. Barnes mentions as liable to happen in the treatment of such cases.A patient in private practice, six years married and without progeny, laboured under yellow vaginal discharges and membranous dysmenorrhcea, which I had reason to believe to be of gonorrhoeal origin.After a prolonged treatment by
Manikin Tracheitis
Authors: George Nicklin
Journal: JAMA (1980)

<h3>To the Editor.—</h3> On recent completion of an American Heart Association course on cardiopulmonary resuscitation, I raised a question concerning the maintenance of a sterile and noninfectious technique in dealing with the manikins, which were used by various physician participants in the course to improve their competency in cardiopulmonary resuscitation. During the course, the manikins were sterilized before each use by alcohol sponges wiped over the mouth and nose area. However, the "lungs" were not sterilizable, and I noticed the day after the course that I had tracheitis. This tracheitis persisted for approximately 72 hours and then cleared gradually. It is my impression that a manikin tracheitis develops in medical technicians and physicians who are taking the cardiopulmonary resuscitation courses because of difficulty in maintaining sterile techniques of the immediate areas outside of the region of the mouth and nose. Participants in cardiopulmonary resuscitation courses and instructors should be alerted
Muscular Hypertrophy of Esophagus
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
INSTITUTIONAL DIETARY PROBLEMS AND THE MEATLESS DIET
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
How many melanomas might be prevented if more people applied sunscreen regularly?
Authors: C.M. Olsen, L.F. Wilson, A.C. Green, N. Biswas, J. Loyalka, D.C. Whiteman
Journal: British Journal of Dermatology (2018)

Malignant melanoma is the most dangerous of the commoner skin cancers, causing many thousands of deaths each year. It has become increasingly common in Western countries over recent decades. Exposure to ultraviolet rays from the sun is the major environmental factor causing melanoma. The application of sunscreen to the skin prior to sun exposure has been shown to reduce the risk of developing melanoma. This collaborative study between cancer epidemiologists in Brisbane, Australia and Manchester, U.K., explores the potential future impact of improved adherence to sunscreen use in Australia and the white population in the U.S.A. These populations were chosen because they have high rates of melanoma, and reliable comparative data on both melanoma incidence and current sunscreen use exist for these populations, allowing projections to be made. Using appropriate computer modelling tools, the study shows that if the populations adhered to a realistically achievable increase in sunscreen use (5% increase in use annually for 10 years from 2012), by 2031 there would be an 11% reduction in the incidence of malignant melanoma in the U.S.A. For Australia the reduction would be 10%. In contrast, if there was a maximum uptake of sunscreen use (100% of population using sunscreen with immediate effect) the corresponding reductions in melanoma by 2031 would be 38% and 34% respectively. These potential reductions in melanoma incidence in this study are rather disappointing, but do nevertheless represent a potential saving of thousands of lives each year with better adherence to sunscreen use.
PROTEIN SENSITIZATION
Authors: A. G. GOULD
Journal: JAMA (1923)

During the college year 1921-1922, a diagnostic and prophylactic study was made of the majority of male students having histories of hay-fever, asthma, eczema or recurring urticaria, at Cornell University. An attempt was made to diagnose these cases by means of allergic reactions to pollen, epidermal, food or bacterial proteins, and to desensitize the students by subcutaneous injections of the offending protein or by having them avoid the offending protein or proteins. The results of both studies are of interest, because of some new additions to the field, and because of their general agreement with the results of other investigators. <h3>HAY-FEVER DIAGNOSTIC STUDY</h3> Of the four kinds of disease studied, hay-fever offered the easiest approach to diagnosis. It was rare indeed to find an uncomplicated spring hay-fever case which did not respond to one or more of the group of pollen proteins which are listed in Table 1. Very satisfactory
Identification of a human splenic marginal zone B cell precursor with NOTCH2-dependent differentiation properties
Authors: Marc Descatoire, Sandra Weller, Sabine Irtan, Sabine Sarnacki, Jean Feuillard, Sébastien Storck, Anne Guiochon-Mantel, Jérôme Bouligand, Alain Morali, Joseph Cohen, Emmanuel Jacquemin, Maria Iascone, Christine Bole-Feysot, Nicolas Cagnard, Jean-Claude Weill, Claude-Agnès Reynaud
Journal: The Journal of Experimental Medicine (2014)

Mouse splenic marginal zone precursors (MZPs) differentiate into marginal zone B (MZB) cells under a signaling pathway involving Notch2 and its ligand, delta-like 1 ligand (Dll1). We report the identification of an MZP subset in the spleen of young children. These MZPs differentiate into MZ-like B cells in vitro in the presence of OP9 cells expressing human DLL1, as demonstrated by the up-regulation of classical MZB cell markers. A set of diagnostic genes discriminating IgM+IgD+CD27+ blood and splenic MZB cells from switched B cells was identified (up-regulation of SOX7, down-regulation of TOX, COCH, and HOPX), and their expression during the induction assay mirrored the one of MZB cells. Moreover, Alagille patients with a NOTCH2 haploinsufficiency display a marked reduction of IgM+IgD+CD27+ B cells in blood, whereas their switched memory B cells are not affected. Altogether, these results argue in favor of the existence of a rodent-like MZB cell lineage in humans.
Cimetidine and duodenal ulcer
Authors: M. Drury
Journal: BMJ (1979)

had no hyperacidic peptic ulceration.As regards the second patient, simply oversewing perforations leads to further surgery in 20% of cases in five years.This is extremely rarely required within two months.2The occurrence and timing of recurrence of ulceration in both cases strongly suggests that cimetidine treatment or its withdrawal was implicated.When H2-blockade of acid-secreting cells is withdrawn, it is more likely to lead to excessive sensitivity to normal stimuli than to hyperplasia.
Genetic and Molecular Analysis of Six Tumor Suppressor Genes in Drosophila melanogaster
Authors: Thomas Loffler, Jasmin Wismar, Heinz Sass, Tomio Miyamoto, Gerhard Becker, Lutz Konrad, Maria Blondeau, Ursula Protin, Sibylle Kaiser, Petra Graf, Martin Haas, Gerd Schuler, Janet Schmidt, Bounpheng Phannavong, Dietmar Gundacker, Elisabeth Gateff
Journal: Environmental Health Perspectives (1990)
Co-Alcoholism
Authors: HERBERT RAKATANSKY
Journal: Annals of Internal Medicine (1984)

Letters and Corrections1 June 1984Co-AlcoholismHERBERT RAKATANSKY, M.D.HERBERT RAKATANSKY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-100-6-921_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The UCLA Conference about alcoholism in the March issue (1) correctly emphasizes the magnitude of the problem. In addition to alcoholic persons themselves, however, many other persons are affected and ill due to alcoholism, including their relatives and friends.These behavioral disturbances and emotional problems are called co-alcoholism, and its diagnosis may be even more obscure than the diagnosis of alcoholism. Because each alcoholic has a cohort of friends and relatives, the number of people affected by co-alcoholism is even larger than the number of people affected by alcoholism.The point is well made in the conference...Reference1. WESTMAXWELLNOBLESOLOMON LDED. Alcoholism. Ann Inter Med. 1984;100:405-16. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: HERBERT RAKATANSKY, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAlcohol Withdrawal AND RELATED NURSING CARE IN OLDER ADULTSCorrection: Al-Anon for Associates of AlcoholicsHERBERT RAKATANSKY, M.D. 1 June 1984Volume 100, Issue 6Page: 921-921KeywordsAlcoholicsAlcoholismEmotions ePublished: 1 December 2008 Issue Published: 1 June 1984 PDF downloadLoading ...
DOES FATIGUE CONTRIBUTE TO SUSCEPTIBILITY TO DISEASE?
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SPIROCIDE AND THE INHALATION METHOD OF TREATING SYPHILIS
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal