tbuckley/cabot-search huggingface dataset:
Medicolegal
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cocaine in Herbal Tea
Authors: Mahmoud A. Elsohly
Journal: JAMA (1986)

<h3>To the Editor.—</h3> South Americans have been drinking coca leaf tea for hundreds of years with no ill effects and some medical benefit. Since December 1983, coca leaf tea has been imported into the United States and sold in grocery and health food stores and through mail order. The tea, packaged in Peru and exported by the National Enterprise of Coca (an agency of the Peruvian Government), is sold as "Health Inca Tea" (HIT) and its ingredients are listed as "decocainized coca leaves." "Mate de Coca" is also available but the Spanish labels do not list ingredients. Both teas are promoted as natural stimulants without caffeine, and advertisements promise that "just one cup leaves you feeling up." Total sales have been estimated at 1.5 million tea bags, and at least one cocaine treatment center supplies patients with the tea as a diuretic and cocaine substitute. The patients report that the
Diabetic Neuropathy
Authors: D A Greene, A F Sima, M A Pfeifer, J W Albers
Journal: Annual Review of Medicine (1990)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease 2019 (COVID-19), emerged in China in December 2019 and quickly spread around the globe, killing more than 4 million people and causing a severe economic crisis. ...Read More
CHINA AND THE OPIUM TRAFFIC.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A phase 1/2 study of TRC105 in combination with sorafenib in hepatocellular carcinoma (HCC).
Authors: Austin G. Duffy, Chi Ma, Susanna Varkey Ulahannan, Oxana V. Makarova-Rusher, Suzanne Fioravanti, Melissa Walker, Baris Turkbey, Jane Trepel, Liang Cao, Seth M. Steinberg, William Douglas Figg, Tim F. Greten
Journal: Journal of Clinical Oncology (2015)

4083 Background: Endoglin (CD105) is an endothelial cell membrane receptor highly expressed on proliferating tumor vasculature, including in HCC. CD105 is essential for angiogenesis and its expression is upregulated by hypoxia and VEGF inhibition. TRC105 is a chimeric IgG1 anti-CD105 monoclonal antibody that inhibits angiogenesis and causes ADCC and apoptosis of proliferating endothelium. Sorafenib is the only FDA-approved drug in HCC and anti-endoglin antibody potentiates sorafenib in preclinical models Methods: Patients with HCC (Childs Pugh A/B7), ECOG 0/1, were enrolled in a phase I study of TRC105 at 3, 6, 10, 15mg/kg q 2wks plus sorafenib 400mg bid. Correlative biomarkers included DCE-MRI, color Doppler ultrasonography, circulating endothelial and endothelial progenitor cells, plasma levels of angiogenic factors, soluble CD105 and tumor IHC for CD105. Samples were also collected for analysis of immune subsets and pharmacokinetics. Results: 21 pts were enrolled (N = 2 inevaluable); 12 with cirrhosis; Hep B/C/NA: 2/10/7; M:F 13:6; Mean age of 60 (range 18-76); 1 DLT (increased AST) occurred at 10mg/kg. The most frequent toxicity was low grade epistaxis. One patient experienced an infusion reaction and was replaced. One patient with coronary stenosis developed a fatal myocardial infarction and one patient developed G3 cerebral tumor hemorrhage. Four of sixteen (25%) pts evaluable for response achieved PR by RECIST (3/6 at Dose Level 4). Four patients had confirmed stable disease, one of whom was treated for 22 months. Median PFS was 4.1 months for first N = 18 patients, 5 months at dose level 4. Conclusions: TRC105 combined with sorafenib was well tolerated at the recommended single agent doses of both drugs. Encouraging evidence of activity (PR rate 25%) was observed and the study is now in the phase 2 stage. Full correlative and clinical data will be presented. Clinical trial information: NCT01306058.
Abstract A1-26: Inhibiting stemness and invasion property of glioma stem cells by biguanide compound
Authors: Junjeong Choi, Ji-Hyun Lee, Jin-Kyoung Shim, Kim Pilnam, Seok-Gu Kang
Journal: Cancer Research (2015)

Abstract Introduction: Ever since pharmacoepidemiologic clues of antineoplastic actions of metformin were reported in 2005, potential application of biguanide for the treatment of several types of cancer has been evaluated. To overcome limited pharmacokinetic properties of prototype biguanides such as metformin and penformin, a newly developed biguanide compound HL156A was developed. In the present, we assessed the potential biologic effect of HL156A on the glioma stemness and invasion properties. Methods: Using patient derived glioma cancer stem cells (gCSCs), we assessed cell viability, AMPK-mTOR pathway, stemness, differentiation, tumor invasion and epithelial-mesenchymal properties of gCSCs. In addition, expression profiles with drug treatment were obtained using Illumina HumanHT-12 v4 Expression BeadChip and gene set enrichment analysis (GSEA) was performed with GSEA application. Orthotopic tumor model was generated and assessed for tumor margin. Results: The compound activated p-AMPK and reduced phosphorylation of mTORC-1-regulated proteins. It decreased stemness of gCSCs, proved by sphere formation assay and decreased expression of stemness markers. The invasive properties of gCSCs were inhibited on 3D invasion assay and the expression of proteins related with epithelial-mesenchymal transition was inhibited by the compound. GSEA revealed cell adhesion related gene set was altered in the compound treated groups. Orthotopic model of the tumor showed less invasive tumor margin on the treatment of the compound. Citation Format: Junjeong Choi, Ji-Hyun Lee, Jin-Kyoung Shim, Kim Pilnam, Seok-Gu Kang. Inhibiting stemness and invasion property of glioma stem cells by biguanide compound. [abstract]. In: Proceedings of the AACR Special Conference on Translation of the Cancer Genome; Feb 7-9, 2015; San Francisco, CA. Philadelphia (PA): AACR; Cancer Res 2015;75(22 Suppl 1):Abstract nr A1-26.
Two Short Courses—Epidemiology and Toxicology
Journal: JNCI Journal of the National Cancer Institute (1985)

Journal Article Two Short Courses—Epidemiology and Toxicology Get access JNCI: Journal of the National Cancer Institute, Volume 74, Issue 5, May 1985, Page 1154, https://doi.org/10.1093/jnci/74.5.1154 Published: 01 May 1985
Issue Information
Authors: Nora Singer, Kelli Allen, Chapel Hill, Shervin Assassi, Cecilia Chung, Eric Gapud, Kim Jones, Brian Kotzin, Angeles Linda, C Li, Jane Diamond, Atlanta Parry, Atlanta Lesley, W Allen, Patricia Mabley, Atlanta Kristin, W Mitchell, Atlanta Emily, W Wehby, Atlanta Weinberg, Atlanta Barraza, Atlanta Swett, Haven Roth, Richard Bucala, Daniel Solomon, Joseph Craft, New Haven, David Felson, Richard Loeser, Peter Nigrovic, Christopher Ritchlin, Rochester Varga, Robert Terkeltaub, San Diego, Michael Weinblatt, Daniel Aletaha, Heather Allore, Lenore Buckley, Daniel Clauw, Ann Arbor, Robert Colbert, Karen Costenbader, Nicola Dalbeth, Kevin Deane, Patrick Gaffney, Oklahoma City, Tatsuya Atsumi, Charles Auffray, Dominique Baeten, Amsterdam André Ballesteros-Tato, Lorenzo Beretta, Bryce Binstadt, Jaime Calvo-Alen, Vitoria Canna, Mark Genovese, Palo Alto, Andrew Haims, Insoo Kang, Haven Kavanaugh, La Jolla, Wan-Uk Kim, Seoul Lim, Anne-Marie Malfait, Paul Monach, Chester Oddis, Andras Perl, Andrew Cope, London Niek De Vries, Amsterdam Jörg, H Distler, Liana Fraenkel, Erica Herzog, Hui-Chen Hsu, Mariana Kaplan, Jonathan Kay, Dwight Kono, Janet Pope, Timothy Radstake, William Robinson, Georg Schett, Nan Shen, Betty Tsao, Ronald Van Vollenhoven, Fredrick Wigley, Martin Kriegel, Francis Lee, Sang-Il Lee, Bing Lu, Tony Merriman, Yukinori Okada, Osaka Raghunathayammani, Winston-Salem Kazuki Yoshida, David Daikh, San Francisco, Paula Marchetta, New York, Charles King, Ellen Gravallese, Mark Andrejeski, Jane Falconer, Anne Murphy, Stephen Young, Andrew Clark, Stefano Tiziani, Monica Guma, Neil Basu, Chelsea Kaplan, Eric Ichesco, Tony Larkin, Richard Harris, Alison Murray, Gordon Waiter, Isabel Lopez-Oliva, Akshay Paropkari, Shweta Saraswat, Stefan Serban, Zehra Yonel, Praveen Sharma, Paola De Pablo, Karim Raza, Andrew Filer, Iain Chapple, Thomas Dietrich, Melissa Grant, Takahisa Suzuki, Shoichi Fukui, Kunihiko Umekita, Junya Miyamoto, Masataka Umeda, Ayako Nishino, Akitomo Okada, Tomohiro Koga, Shin-Ya Kawashiri, Naoki Iwamoto, Kunihiro Ichinose, Mami Tamai, Keita Fujikawa, Toshiyuki Aramaki, Akinari Mizokami, Naoki Matsuoka, Yukitaka Ueki, Katsumi Eguchi, Shuntaro Sato, Janneke De Winter, Manouk De Hooge, Marleen Van De Sande, Henriëtte De Jong, Lonneke Van Hoeven, Anoek De Koning, Inger Berg, Roberta Ramonda
Journal: Arthritis & Rheumatology (2018)
Peripheral blood access for hyperalimentation. Use of expanding polytetrafluoroethylene arteriovenous conduit
Authors: T. J. Buselmeier
Journal: JAMA (1977)

TOTAL parenteral nutrition may be complicated in patients who have central venous lines and who require long-term therapy. Use of standard arteriovenous fistulas has generally been unsuccessful in the normally coagulable nonuremic patient. Arteriovenous shunts have been successful at times but have their drawbacks.<sup>11</sup>An expanded polytetrafluoroethylene graft was used for repeated vascular access for hyperalimentation in a patient whose initial alimentary therapy was interrupted by recurrent infection of the central venous line used for caloric administration. <h3>Report of a Case</h3> A 36-year-old obese woman was admitted to the University of Minnesota Hospitals. She had several draining abdominal fistulas two months after a jejunoileal bypass had been performed. She had hepatic insufficiency, several abdominal fistulas, and diffuse signs of malnutrition. A central venous line was placed, and hyperalimentation was started in February 1977 using a combination of soybean oil, 25% dextrose in water and 4.25% amino acid, synthetic solution
ANTITUBERCULIN.
Authors: JOSEPH McFARLAND
Journal: JAMA (1897)

The enthusiastic reception of the "Blutserum- Blutserumtherapie" led many of our esteemed colleagues to entertain the most ardent expectations of miraculous results in all divisions of the field of infective diseases. The constantly increasing number of recoveries from diphtheria that were reported and the occasional recoveries from tetanus that were hurried into print, convinced large numbers of professional, as well as lay men, that "Blutserumtherapie" led to an almost unlimited field of usefulness. In those early days, I was frequently asked what the chances of serum treatment were likely to be and why I did not hasten to occupy that field and be among the first to benefit mankind with that much-needed boon, a "cure for consumption.". My answers to these inquiries were received with incredulous looks, and my endeavors to show why serum therapy for tuberculosis was likely to fail in the majority of cases, were unheeded. It was
Advances in Understanding of Alcoholism Initiate Evolution in Treatment Programs
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Care of Tuberculosis Patients: Reprise
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Marriages
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
International Abstracts
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The paradox of appropriate care
Authors: J. E. Wennberg
Journal: JAMA (1987)

A Bostonian is about twice as likely to undergo a carotid endarterectomy as a New Havenite; for coronary bypass operations the risk is the reverse.<sup>1</sup>New Haven residents experience substantially higher rates for hysterectomies and back surgery, while the rates for knee and hip replacements are much greater for Bostonians. Across a wide spectrum of common acute and chronic conditions such as back pain, gastroenteritis, pneumonia, and diabetes, the incidence of hospitalization is much greater for residents of Boston than for those of New Haven, even though the populations are very similar in demographic characteristics related to the need for care. These overall differences in utilization translate into large differences in expense to third-party insurers. For example, in 1982, the Medicare program's outlays were $2647 per enrollee for Boston residents while the average expenditure in New Haven county was $1561. As recently emphasized by Secretary of the Department of
Medical aspects of north sea oil.
Authors: J Mccrae, Mr Cumming, W Davidson, K Donald, R Houston, G Roberts, H Robinson, G Smith, J Taylor, C Falconer, Whittington Hospital, London N19 3ua, Arnold Bloom, T Hayes, D Gamble
Journal: BMJ (1975)

In May 1974 the Scottish Council of the B.M.A. set up a working party* to study the medical aspects of the rapid growth of the oil industry in Scotland and the North Sea, and its report is being published this week.Copies of thefull report, The Medical Implica- tions of Oil Related Industry, are available from the B.M.A. price C1 00.Printed below is a condensed version of the report's main findings.The oil industry operates in two contrasting situations: on land, and on sea.The onshore sites in Scotland are all on the coast line and are placed from Campbeltown to Burntisland.Often their choice has been determined by the local depth of the sea, which in turn has positioned them in remote, "out back" areas.Remoteness has a bearing on medical care.There are steel platform sites at Nigg Bay, Ardersier, and Methil; concrete platform sites at Ardyne and Loch Kishorn; platform sites with planning permission at Hunterston, Portavadie, Campbeltown, Alness, and Burntisland; oil or gas terminals at Sullom Voe, Flotta, Cruden Bay, Grangemouth, Dalmeny, and St. Fergus and service bases at Shetland, Orkney, Peterhead, Aberdeen, Montrose, Dundee and Leith.Aberdeen-not least owing to its geographical proximity-is accepted as the oil capital in the North-East and provides the centre of communications, and we believe that Shetland as a base will come next in activity.Since 1971 some 200 firms have moved into the Aberdeen/Angus area; 5500 houses are under construction and a further 2000 await approval.The expression "offshore" is misleading.The nearest rigs are 100 miles off the coast-
Research scientist
Authors: Irene M. Pepperberg
Journal: Behavioral and Brain Sciences (2002)

Viewing communication as a dynamic system is laudable; arguing that the approach is novel is questionable. Some researchers studying nonhuman communication other than ape language have been using such an approach for decades. A brief description of an avian system provides one such example. Interestingly, the dynamic social system described in the target article may have a developmental neuronal basis.
A measles vaccine withdrawn.
Journal: BMJ (1969)

A. M. Connell and his colleagues9 have been able to define a syndrome of abdominal pain associated with colonic hyper- motility after meals.These are patients with "x-ray- negative dyspepsia " who suffer from uncomfortable flatu- lence and sometimes severe pain, particularly after food, and who also have overactivity of the colon.The relationship between the hypermotility of the colon and the pain is uncertain, because vigorous contractions can occur without symptoms of any kind, but these authors suggest the likeliest explanation is that the exaggerated segmental contraction produces a functional obstruction.Recently D. J. Holdstock and his colleagues10 from the Central Middlesex Hospital have described the results of manometric studies in nine patients suffering from attacks of severe abdominal pain for which no cause was found after thorough investigation, including in some cases laparotomy.These attacks seemed to be related to changes in intraluminal pressures in either the small or the large bowel.Seven of the patients developed typical attacks of abdominal pain during the manometric studies, and in each of these cases the symptoms coincided with marked alterations in the records of intraluminal pressure.In four patients the intra- venous injection of propantheline produced simultaneous relief of pain and reduction of activity in the bowel, which strongly suggests a relationship between the two.However, two patients whose records were qualitatively similar to the others remained free of pain throughout their tests despite the fact that pain was a prominent feature of their com- plaint.The often disappointing results of treatment with oral propantheline and related drugs in the management of such cases can be accounted for by the difficulty of obtaining adequate dosage without intolerable side-effects.