tbuckley/cabot-search huggingface dataset:
Halothane Hepatotoxicity
Authors: MICHAEL C. BRAUNSTEIN
Journal: Annals of Internal Medicine (1979)

Letters and Corrections1 January 1979Halothane HepatotoxicityMICHAEL C. BRAUNSTEIN, M.D.MICHAEL C. BRAUNSTEIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-1-131_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Miller, Dwyer, and Klatskin state in their paper "Halothane Hepatitis: Benign Resolution of a Severe Lesion" (Ann Intern Med89:212-215, 1978) that halothane hepatitis is a sensitization reaction. There is no evidence for this mechanism at the cellular level and little evidence at the clinical level. At the cellular level, the antigen has not been found. At the clinical level, there is also little support. Fever is no more common after halothane than after other anesthetics (1). The causes of eosinophilia are legion and include viral hepatitis (2, 3). Tests for antimitochondrial antibodies are conflicting (4) and...References1. DYKES M: Unexplained postoperative fever. Its value as a sign of halothane sensitization. JAMA 216:641-644, 1971 CrossrefMedlineGoogle Scholar2. DYKESGILBERTSCHURCOHEN MJPE: Halothane and the liver: a review of the epidemiologic, immunologic and metabolic aspects of the relationship. Can J Surg 15:217-238, 1972 MedlineGoogle Scholar3. DAL SANTO G (ed.): Biotransformation of general anesthetics. Int Anesthesiol Clin 12(2):1-182, 1974 Google Scholar4. VAN DYKE R: Current concepts of halothane metabolism. Audio Digest 19(9), 1977 Google Scholar5. BROWN B: Current concepts of halogen hepatotoxicity. Audio Digest 18(5), 1976 Google Scholar1. FARRSPECTOR RS: What is asthma, in The Asthmatic Patient in Trouble, edited by PETTY TL. Greenwich, Connecticut, C.P.C. Communications, Inc., 1975 Google Scholar2. WILLIAMSBEUTLERERSLEYRUNDLES WEAR (eds.): Hematology. New York, McGraw-Hill, 1972, p. 657 Google Scholar3. WINTROBE M: Clinical Hematology, 7th ed. Philadelphia, Lea & Febiger, 1974, p. 1285 Google Scholar4. MIDDLETONREEDELLIS ECE (eds.): Allergy: Principles and Practice, vol. 2. St. Louis, C. V. Mosby, 1978, p. 604 Google Scholar5. BIERMANVAN ARSDEL CP: Penicillin allergy in children: the role of immunological tests in its diagnosis. J Allergy 43:267-272, 1969 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: C.C.A.A., Inc. Las Vegas, NV 89109 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByGeneral anaesthetics and therapeutic gases 1 January 1979Volume 90, Issue 1Page: 131-132KeywordsAnestheticsAntigensAntimitochondrial antibodiesEosinophiliaFeversHepatitisHepatitis ALesions Issue Published: 1 January 1979 PDF DownloadLoading ...
Laser may have uses in bladder tumors, esophageal blockages
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 5289: Abnormally Tight Domain-Domain Interaction at Mutation Site Could be a Primary Cause of Catecholaminergic Polymorphic Ventricular Tachycardia: Insight from RyR2 <sup>S2246L/+</sup> Knock-In Mouse Model
Authors: Takeshi Suetomi, Masafumi Yano, Xiaojuan Xu, Makoto Ono, Hitoshi Uchinoumi, Hiroki Tateishi, Shinichi Okuda, Shigeki Kobayashi, Takeshi Yamamoto, Yasuhiro Ikeda, Tomoko Ohkusa, Masunori Matsuzaki
Journal: Circulation (2008)

Mutations in cardiac ryanodine receptor 2 (RyR2) have been shown to be associated with catecholaminergic polymorphic ventricular tachycardia (CPVT). To study the underlying mechanism of this lethal arrhythmia, we developed knock-in (KI:RyR2 S2246L/+ ) mice model with the human CPVT-associated RyR2 mutation (S2246L). The KI mice revealed no structural or histological abnormality in hearts, and also had no contractile or relaxation dysfunction at rest. In all KI mice (n=6), however, bi-directional ventricular tachycardia (VT) was observed after exercise with treadmill (Ex:6/6), but not observed in wild-type (WT) mice (Ex:0/7). In isolated cardiomyocytes, line scan images were obtained to measure local Ca 2+ release events using a confocal microscopy with fluo-4 AM as a Ca 2+ indicator. In the KI cardiomyocytes, the frequency of Ca 2+ sparks (SpF: s −1 ·100μm −1 ) was much more increased in response to 100 nM isoproterenol than in WT cardiomyocytes (KI:4.7±0.5 vs WT:1.9±0.2, p&lt;0.01). Using the canine cardiac SR, we fluorescently labeled RyR2 with methylcoumarin acetamido (MCA), using either DP 2232–2266 or DP 2232–2266 mut; Ser is mutated to Leu (S2246L), as a carrier; DP 2232–2266 harbors the same CPVT mutation site as KI mice (S2246L). The binding affinity of DP 2232–2266 mut to RyR2 (Kd=0.08μM) was higher than that of DP 2232–2266 (Kd=0.32μM), suggesting that abnormally tight interaction of the domain pair (between the domain2232–2266 and another putative domain) may be formed by the S2246L mutation. Interestingly, addition of DP 2232–2266 to the SR dose-dependently inhibited the cAMP (30μM)-induced Ca 2+ leak; IC50=0.1μM, although DP 2232–2266 had no effect on the cAMP-induced increase in 2808Ser phosphorylation. In conclusion, some type of RyR2 mutation in CPVT may causatively induce hyper-activated channel gating by forming abnormally tight domain-domain interaction, triggering diastolic Ca 2+ release and hence lethal arrhythmia. Interruption of such abnormal domain-domain interaction (by competing with native domain) may lead to a new therapeutic strategy against CPVT.
ASBESTOSIS IN URBAN POPULATIONS
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The New Year and the ANNALS
Authors: J. R. E.
Journal: Annals of Internal Medicine (1968)

Editorials1 January 1968The New Year and the ANNALSJ. R. E., E. J. H.J. R. E.Search for more papers by this author, E. J. H.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-68-1-241 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOnce again the coming of the New Year leads your editors to look to the needs of the future as well as to the achievements of the past. A journal, like a person, has an ongoing life that strives to approach an ideal but never arrives. In a word, there is always room for improvement—a journal needs to grow. We have tried to keep your journal growing in quality and in usefulness.During the past year we have introduced the new feature of duplicateAbstracts of Articlesappearing in the same issue. These abstracts, printed in 3- by 5-inch boxes... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 January 1968Volume 68, Issue 1Page: 241-242KeywordsForecasting ePublished: 1 December 2008 Issue Published: 1 January 1968 PDF downloadLoading ...
From the National Institutes of Health
Authors: James B. Wyngaarden
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THANK YOU, DOCTOR ACTON
Authors: J. R. E.
Journal: Annals of Internal Medicine (1961)

Editorials1 March 1961THANK YOU, DOCTOR ACTONJ. R. E.J. R. E.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-54-3-588 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWith the January, 1961, issue, there came to an end the last editorial service to be performed in Baltimore. For almost 23 years, with the exception of an interval for war service, Dr. Conrad Acton of Baltimore has carefully screened each sheet of page-proof of each issue of the ANNALS. To him this task was a challenge in the unending battle against error, to this task he brought professional acumen and a dedicated thoroughness. To the former editorial staff he must have been a bulwark; to the new editorial staff he has been a great help in a time of... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1961Volume 54, Issue 3Page: 588-588 ePublished: 1 December 2008 Issue Published: 1 March 1961 PDF downloadLoading ...
Commentaire du travail de Tae HJ et al., pp. 845
Journal: Endoscopy (2014)

See also: Deep biopsy via endoscopic submucosal dissection in upper gastrointestinal subepithelial tumors: a prospective studyEndoscopy 2014; 46(10): 845-850DOI: 10.1055/s-0034-1377627
Incorporating geriatric patient reported outcomes into novel screening tool of distress and supportive care concerns.
Authors: Christine B. Weldon, Joanna Martin, Amy Scheu, Paramjeet Khosla, Betty Roggenkamp, Rosa Berardi, Selina Lai-ming Chow, Julia Rachel Trosman, Mary Pasquinelli, Lawrence Eric Feldman, William Dale, Sean O'Mahony, James Gerhart, Patricia B. Mumby, Ana Gordon, Lauren Allison Wiebe, Catherine Deamant
Journal: Journal of Clinical Oncology (2018)

10115 Background: The Institute of Medicine (IOM) 2013 Report recommends that supportive oncology care start at cancer diagnosis; the Commission on Cancer (CoC) Standard 3.2 requires distress screening and indicated action. The Supportive Oncology Collaborative, collaborative of 100+ clinicians funded by The Coleman Foundation, developed a patient-centric screening tool (CSOC-ST) adapted from ASCO Distress, NCCN Distress Problem List, IOM report and CoC standards, and other validated sub-tools (Weldon, ASCO-Q 2017). The Collaborative then revised the CSOC-ST tool to align with geriatric guidelines. Methods: Literature and guidelines review of geriatric screening, added items to CSOC-ST, and piloted at 4 sites. Descriptive statistics and Fisher’s exact test used. Results: 473 patients screened with added geriatric relevant items to CSOC-ST: self-care concerns (PROMIS Instrumental Support), living alone (ASCO Distress 2014), and memory / cognition (PROMIS item bank). Treatment/care concern items were revised to identify interest in health care power of attorney and advance directives. Geriatric related items endorsed by patients, see Table. PHQ4, Anxiety and Depression, average score 2.4 (mild > 3). Higher scores on the PHQ-4 were significantly associated with each of the following: self-care concerns, memory/cognition concerns and specific treatment/care concerns (p < .0001). Conclusions: Pilot results and comparison to geriatric guidelines identified important items to support geriatric patient reported outcomes screening. After pilot, added 3 items for falls/frailty. Eight sites implementing this CSOC-ST. Screening Item Frequency n = 473 I want help letting my family, friends and team know my medical wishes if unable to do so myself [health care power of attorney] 38% I want help discussing, with my family and friends, my treatment options and what is important to me [advance directives] 36% I have difficulty concentrating, difficulty remembering things, and/or difficulty finding the words I want to say 35% Are you concerned about having someone available to help: if you cannot get out of bed, you feel sick and cannot do daily chores, and/or you cannot run errands? 31% I live alone 26%
AN EXTRAORDINARY CASE OF SITUS INVERSUS VISCERUM TOTALIS
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Cover
Authors: M. Therese Southgate
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Decreased expression of p33ING1 mRNA in lymphoid malignancies
Authors: M. Ohmori, M. Nagai, T. Tasaka, H.P. Koeffler, K. Riabowol, J. Takahara
Journal: American Journal of Hematology (1999)

The ING1 is a newly cloned putative tumor-suppressor gene, which is involved in the p53 signaling pathway. We found decreased expression of ING1 mRNA in 4 of 5 T-cell lines and 5 of 11 B-cell lines including two Burkitt lymphomas and two myelomas. These observations suggest that decreased ING1 expression might play an important role in the development or progression of some lymphoid tumors. Polymerase chain reaction-SSCP and sequencing analyses found neither point mutations nor small deletions in the ING1 gene, suggesting that decreased expression is due to transcriptional or post-transcriptional mechanisms. Am. J. Hematol. 62:118–119, 1999. © 1999 Wiley-Liss, Inc.
Vascular Access in Patients Receiving Hemodialysis
Authors: Nauman Qureshi
Journal: JAMA (1997)

<h3>To the Editor.</h3> —The increasing use of arteriovenous (AV) grafts compared with fistulas in the United States reported by Dr Hirth and colleagues<sup>1</sup>is all the more surprising given the increased availability of a dialysis catheter with the subcutaneous tunnel (Perm catheter, Quinton, Seattle, Wash). Fistulas generally require 6 to 12 weeks to "mature," which is 3 to 4 times longer than grafts.<sup>2</sup>Dialysis is needed during the interim, especially among the late-referred patients. A tunneled catheter is preferable for longer-term "temporary" access. The increased availability of this type of catheter between 1986 and 1990 would presumably have allowed the permanent access more time to mature and, hence, would have favored arteriovenous fistula (AVF) placement over AV graft placement. In addition, Hirth et al<sup>1</sup>mention that in Japan 100% of patients newly treated with hemodialysis receive a fistula as their first method of access. Is there a
PROLONGED ADVERSE REACTIONS TO LSD
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin–induced intestinal fluid secretion
Authors: Tonghui Ma, Jay R. Thiagarajah, Hong Yang, Nitin D. Sonawane, Chiara Folli, Luis J.V. Galietta, A.S. Verkman
Journal: Journal of Clinical Investigation (2002)

Secretory diarrhea is the leading cause of infant death in developing countries and a major cause of morbidity in adults. The cystic fibrosis transmembrane conductance regulator (CFTR) protein is required for fluid secretion in the intestine and airways and, when defective, causes the lethal genetic disease cystic fibrosis. We screened 50,000 chemically diverse compounds for inhibition of cAMP/flavone–stimulated Cl– transport in epithelial cells expressing CFTR. Six CFTR inhibitors of the 2-thioxo-4-thiazolidinone chemical class were identified. The most potent compound discovered by screening of structural analogs, CFTRinh-172, reversibly inhibited CFTR short-circuit current in less than 2 minutes in a voltage-independent manner with KI approximately 300 nM. CFTRinh-172 was nontoxic at high concentrations in cell culture and mouse models. At concentrations fully inhibiting CFTR, CFTRinh-172 did not prevent elevation of cellular cAMP or inhibit non-CFTR Cl– channels, multidrug resistance protein-1 (MDR-1), ATP-sensitive K+ channels, or a series of other transporters. A single intraperitoneal injection of CFTRinh-172 (250 μg/kg) in mice reduced by more than 90% cholera toxin–induced fluid secretion in the small intestine over 6 hours. Thiazolidinone CFTR inhibitors may be useful in developing large-animal models of cystic fibrosis and in reducing intestinal fluid loss in cholera and other secretory diarrheas.
Probable Trichomonas vaginalis epididymitis
Authors: A. D. Amar
Journal: JAMA (1967)

ONLY within the past decade has infection with<i>Trichomonas vaginalis</i>as the explanation for a significant proportion of cases of "nonspecific" urethritis been widely recognized. As far as I am aware, however, attention has not been drawn to<i>T vaginalis</i>as a cause of epididymitis. That trichomoniasis is transmitted venereally, at least in most instances, appears to be rather well established.<sup>1"</sup>The importance of adequate, and if repeated examination of the symptomatic or asymptomatic sexual partner of the woman with this disease, and of eradication of the infection in the male if treatment is to have permanent effect in the female, has been stressed by Perl<sup>3</sup>and others. It is equally true that, for the man with this disease, effectual management must include adequate investigation and treatment of the female partner. Trichomoniasis, long familiar to gynecologists, is thus also a problem for the urologist and the family physician.