tbuckley/cabot-search huggingface dataset:
Improved Outcome of Allogeneic Transplantation in High-Risk Multiple Myeloma Patients After Nonmyeloablative Conditioning
Authors: Ashraf Badros, Bart Barlogie, Eric Siegel, Michele Cottler-Fox, Maurizio Zangari, Athanasios Fassas, Christopher Morris, Elias Anaissie, Frits Van Rhee, Guido Tricot
Journal: Journal of Clinical Oncology (2002)

PURPOSE: We present our experience with relapsed and recently diagnosed patients with high-risk multiple myeloma (MM) receiving immunosuppressive, nonmyeloablative melphalan (MEL)-based conditioning regimens (mini-allograft). PATIENTS AND METHODS: Thirty-one MM patients received allografts from HLA-matched siblings (n = 25) or unrelated donors (n = 6) using a mini-allograft. Seventeen had progressive disease (PD) and 14 had responsive disease (RD) (six with primary RD and eight with responsive relapse). Thirty patients had received one (n = 13) or two or more (n = 17) prior autologous transplantations (ATs). Median age was 56 years (range, 38 to 69 years). Twenty-one patients had chromosome 13 abnormality. Two patients were hemodialysis dependent. Blood and bone marrow grafts were administered to 28 and three patients, respectively. Donor lymphocyte infusions were given to 18 patients either to attain full donor chimerism (n = 6) or to eradicate residual disease (n = 12). RESULTS: By day 100, 25 (89%) of 28 patients were full donor chimeras, one was a mixed chimera, and two had autologous reconstitution. Acute graft-versus-host disease (GVHD) developed in 18 patients (58%), and 10 progressed to chronic GVHD (limited in six and extensive in four). At a median follow-up of 6 months, 19 (61%) of 31 patients achieved complete/near complete remission. Twelve patients (39%) have died: three of PD, three of early treatment-related mortality (TRM) (before day 100), and six of late TRM. Median overall survival (OS) was 15 months. At 1 year, there was a significantly longer event-free survival (86% v 31%, P = .01) and OS (86% v 48%, P = .04) when a mini-allograft was performed after one versus two or more prior ATs, respectively. When compared with historical MM controls (n = 93) receiving conventional allografts, early TRM was significantly lower (10% v 29%, P = .03), and OS at 1 year was better (71% v 45%; P = .08) in the mini-allograft MM patients. CONCLUSION: Mini-allograft induced excellent disease control in MM patients with high-risk disease, but is still associated with a significant GVHD.
Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachyury (T) gene family Li, Q.Y. et al. Nat. Genet. 15, 21–29 Mutations in human TBX5 cause limb and cardiac malformation in Holt-Oram syndrome Basson, C.T. et al. Nat. Genet. 15, 30–35
Journal: Trends in Genetics (1997)
Acute ischemic optic neuropathy
Authors: J. A. Goodwin
Journal: JAMA (1985)

Acute anterior ischemic optic neuropathy (AION) is a common cause of profound visual loss in the elderly and the not-so-elderly and is often associated with systemic disorders. Even so, this condition is not frequently discussed in the medical literature outside ophthalmology specialty journals. For these reasons it is appropriate to call readers' attention to an article that appears in the August issue of Archives OF Ophthalmology in which Guyer et al<sup>1</sup>have analyzed the incidence of cerebrovascular and cardiovascular events in patients with ischemic optic neuropathy. As the name implies, acute anterior ischemic optic neuropathy is defined as an infarct of the optic nerve, usually at the level of the optic disc. This results in abrupt visual loss in one eye and swelling of the optic nerve head.<sup>2</sup>The area of ischemic damage is limited to a small region within the optic nerve, so there is generally no
Medical Education Programs Sponsored by Governmental Agencies
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Geneeskundige Gids, Den Haag
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MEMBERS of the HOUSE of DELEGATES
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
New Catheter Therapy for Air Embolism
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Chloramphenicol Palmitate Dosage
Journal: JAMA (1964)

and enchondral new bone formation; arthritis and periarthritis; synovitis; tendonitis and peritendinitis; focal myositis (near affected bones and joints only); and perivasculitis, non-necrotising (infre¬ quently seen).Plasma-cell neoplasms were produced in seven of 64 mice after intraperitoneal injections of heat- killed Staphylococcus-pa.va.tan oil adjuvant emul¬ sion by Potter and Robertson.5According to Lieberman and Mantel,8 Staph aurews-paraffin oil adjuvant mixtures induced as- cites earlier than adjuvant alone.Several of these mice developed plasma-cell tumors after six to eight months.Mansmann,2 referring to the above, emphasizes
A Single Session With an Earthquake Simulator for Traumatic Stress in Earthquake Survivors
Authors: M. Basoglu
Journal: American Journal of Psychiatry (2003)

OBJECTIVE: This study examined the effectiveness of a single session of earthquake simulator-assisted exposure treatment of traumatic stress in earthquake survivors. METHOD: Ten earthquake survivors in Turkey were given one session of exposure to simulated earthquake tremors. Assessments were at pre- and postsession and at 2, 4, 8, and 12 weeks posttreatment. RESULTS: All measures showed significant improvement at all assessments. Eight patients were markedly and two slightly improved at follow-up. CONCLUSIONS: A single exposure session with an earthquake simulator appears to be effective in treating postearthquake traumatic stress. Controlled studies are needed to confirm these findings.
Data Torturing
Authors: J L Mills
Journal: New England Journal of Medicine (1993)

“If you torture your data long enough, they will tell you whatever you want to hear” has become a popular observation in our office. In plain English, this means that study data, if manipulated in enough different ways, can be made to prove whatever the investigator wants to prove. Unfortunately, this is generally true. Because every investigator wants to present results in the most exciting way, we all look for the most dramatic, positive findings in our data. When this process goes beyond reasonable interpretation of the facts, it becomes data torturing. The unfortunate result of torturing data is the . . .
Challenges for Kids With Seizures
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
DABIGATRAN VERSUS WARFARIN IN PATIENTS WITH ATRIAL FIBRILLATION - AN ANALYSIS OF PATIENTS UNDERGOING CARDIOVERSION
Authors: Meghashyam J. Koti, Amit Parekh, Stuart J. Connolly, Lars Wallentin, Paul A. Reilly, Salim Yusuf, Rangadham Nagarakanti, Janice Pogue, Gregory C. Flaker, Michael D. Ezekowitz
Journal: Journal of the American College of Cardiology (2010)
DIRE CONSEQUENCES OF A PHYSICIAN OVERSUPPLY
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AB0529 Rituximab therapy monitoring by mtor, autophagy-related ULK1, caspase 3, CDK-inhibitor P21, TNF alpha, and osteoclast-specific cathepsin K and gelatinase MMP-9 gene expression in the peripheral blood of rheumatoid arthritis patients
Authors: E.V. Tchetina, K.H. Kuzikyants, A.Y. Devyataikina, G.V. Lukina, E.L. Nasonov
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovial hyperplasia, mononuclear cell infiltration, bone erosion and joint destruction. Altered rates of cell proliferation and apoptosis were also observed in RA. We hypothesized that expression of the genes responsible for cell growth and proliferation (mTOR, p21), autophagy (ULK1), apoptosis (caspase 3), inflammation (TNFalpha), and bone resorption (cathepsin K and gelatinase MMP-9) measured in the peripheral blood could serve important biomarkers for anti-rheumatic therapy monitoring. <h3>Objectives</h3> To find peripheral blood gene expression indicators pointing to treatment efficacy of rituximab in RA patients. <h3>Methods</h3> 12 seropositive RA females aged 52±12.0 years old, disease duration 7.6±5.8 years (with previous failure to DMARD and anti-TNFalpha blockers) treated with rituximab (0.5-1g) for a single treatment course, and 47 healthy age-matched control femaleswere examined in this study. Clinical response was assessed by disease activity score (DAS) 28, erythrocyte sedimentation rate (ESR), serum levels of anti-CCP antibodies, C-reactive protein (CRP), and rheumatoid factor (RF). Bone erosion and joint space narrowing scores were monitored by X-ray analysis. Total RNA isolated from the peripheral blood was used in gene expression studies performed with quantitative Real-time RT-PCR. p70-S6K, p21, and caspase 3 protein levels were quantified by ELISA. <h3>Results</h3> Expression of all the examined genes measured in the peripheral blood was significantly upregulated (p&lt;0.05) in RA patients compared to control at baseline. Rituximab treatment resulted in a significant decrease (p&lt;0.05) in DAS 28, ESR, and CRP values. This was associated with significant downregulation of mTOR, p21, caspase 3, ULK1, MMP-9, and cathepsin K gene expression, which attained the levels observed in healthy subjects. TNFalpha gene expression has also decreased (p&lt;0.05) versus the baseline values. However it remained significantly higher than that in control subjects. No effect on erosion numbers or joint space narrowing was observed in response to rituximab therapy. <h3>Conclusions</h3> Our results show that the examined gene expression measured in the peripheral blood could provide essential information for disease monitoring in RA patients treated with rituximab. Residual upregulated TNFalpha gene expression after rituximab treatment course might indicate the risk of further disease relapse. <b>Acknowledgments:</b> This study was funded by Russian Foundation for Basic Research (project no. 09-04-01158-r and no. 12-04-00038-r). <h3>Disclosure of Interest</h3> None Declared
Unilateral Superior Vena Caval Obstruction in a Case of Bilateral Superior Venae Cavae
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Behçet's Syndrome
Authors: D. Geraint James
Journal: New England Journal of Medicine (1979)

The Royal Society of Medicine of London has recently held a multidisciplinary symposium on Behçet's syndrome, arranged by Professor T. Lehner of Guy's Hospital and Dr. Colin Barnes of the London Hospital; the transactions are to be published shortly.1 Behçet2 was a Turkish dermatologist who described in 1937 the triad of relapsing iridocyclitis with recurrent oral and genital ulceration. The numerous masquerades of this disease are reminiscent of syphilis in the pre-penicillin era. It was always important to remain alert to the possibility of syphilis; otherwise, it was occasionally overlooked. The same may now be said for the multisystem patterns . . .
Sex Determination and Differentiation
Authors: Joel Howell
Journal: New England Journal of Medicine (2004)

current understanding of obesity took root, a cult of thinness had developed, from which we have not yet emerged.Eighteenth-century critics shared our contemporary concern about overpopulation.William Godwin trusted individuals to solve the problem, believing that as medicine enabled people to live forever, sexual urges would abate and reproduction would thus cease.Perhaps the most poignant part of this book comes in Porter's discussion of the great historian and autobiographer Edward Gibbon, author of the classic, six-volume Decline and Fall of the Roman Empire.Gibbon suffered from a whole host of painful and obvious ailments.But those ailments were merely of the body, subordinate to the life of the enlightened mind.Gibbon did not believe in an immortal soul, but he hoped that his Memoirs would mean that "one day his mind [would] be familiar to the grandchildren of those who are yet unborn."As Porter observed, "His mind will thus live on" through his immortal words.One could make the same observation for the words of Roy Porter, and for that we all should be very thankful.
Our Journal.
Authors: J. F. Jenkins
Journal: JAMA (1896)

Tecumseh, Mich., July, 4, 1896. <h3>To the Editor:</h3> —TheJournal of the American Medical Associationwas born and passed through its early infantile life in Chicago, arrived at robust manhood in that city, and in Chicago I vote forThe Journalto remain, where it will be in touch with cosmopolitan schools and hospitals. Respectfully,
Reclassification of the Thrombocytopenias by the Cr<sup>51</sup>-Labeling Method for Measuring Platelet Life Span
Authors: Phin Cohen, Frank H. Gardner, G. Octo Barnett
Journal: New England Journal of Medicine (1961)

Predominant Peripheral DestructionThe "immune" variety of idiopathic thrombocytopenic purpura illustrates the third category of lifespan studies of Cr51-labeled platelets — namely, thrombocytopenia secondary to increased platelet destruction with a relatively normal or increased production. This is exemplified by the response noted in Figure 7. The initial study was performed at a time when a bleeding diathesis was evident and the platelet count was 10,000 per cubic millimeter. Isologous platelets showed a markedly shortened life span. Treatment with prednisone raised the platelet count, reversed the bleeding diathesis and increased the half life of isologous Cr51-labeled platelets to one and . . .
Editorial: Mitochondrial antibodies in collagen disorders.
Journal: BMJ (1974)

As to acute overdosage, both aspirin and paracetamol may cause fatal poisoning.From equal numbers of tablets the hepatic damage produced by paracetamol22 is more likely to be fatal than the effects of aspirin poisoning.But recent ad- vances in the treatment of paracetamol poisoning give hope that early treatment will save many lives.23To sum up, aspirin remains a satisfactory mild analgesic for many patients.It should not be taken regularly over a long period except under medical supervision, and the doctor should keep in mind the possibility ofoccult loss ofblood as a cause of iron deficiency anaemia.In patients for whom aspirin is inadvisable or contraindicated, or who cannot tolerate it because of dyspepsia, paracetamol is usually a satisfactory alternative.Patients should be warned of the danger of overdosage with paracetamol.In terms of efficacy as an analgesic phenacetin does not have any advantages over these two drugs and it is potentially more toxic.Thus there does not appear to be a place for the prescription of phenacetin in medical practice.
Aplastic Anemia in a Petrochemical Factory Worker
Authors: Young Mann Baak, Byoung Yong Ahn, Hwang Shin Chang, Ji Hong Kim, Kyoung Ah Kim, Young Lim
Journal: Environmental Health Perspectives (1999)

A petrochemical worker with aplastic anemia was referred to our hospital. He worked in a petroleum resin-producing factory and had been exposed to low-level benzene while packaging the powder resin and pouring lime into a deactivation tank. According to the yearly environmental survey of the working area, the airborne benzene level was approximately 0.28 ppm. Exposure to benzene, a common chemical used widely in industry, may progressively lead to pancytopenia, aplastic anemia, and leukemia. The hematotoxicity of benzene is related to the amount and duration of exposure. Most risk predictions for benzene exposures have been based on rubber workers who were exposed to high concentrations. In the petroleum industry, the concentration of benzene is relatively low, and there are disputes over the toxicity of low-level benzene because of a lack of evidence. In this paper we report the case of aplastic anemia induced by low-level benzene exposure.