Vitamin K to Correct Overanticoagulation
Authors: Robert C. Pendleton
Journal: Annals of Internal Medicine (2009)

Letters15 September 2009Vitamin K to Correct OveranticoagulationRobert C. Pendleton, MD and Sara Vazquez, PharmD, BCPS, CACPRobert C. Pendleton, MDFrom University of Utah, Salt Lake City, UT 84108.Search for more papers by this author and Sara Vazquez, PharmD, BCPS, CACPFrom University of Utah, Salt Lake City, UT 84108.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-151-6-200909150-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We read with interest the article by Crowther and colleagues (1) evaluating the efficacy of low-dose oral vitamin K to correct excessive anticoagulation in patients receiving warfarin. First, Crowther and colleagues should be commended for carrying out such an important and well-designed study in an area that has received little attention. Despite warfarin accounting for one of the highest annual rates of adverse drug event–related deaths in the United States, the management of excessive anticoagulation in a clinical practice setting has received little study.Although Crowther and colleagues could not demonstrate a reduction in bleeding events with ...References1. Crowther MA, Ageno W, Garcia D, Wang L, Witt DM, Clark NP, et al. Oral vitamin K versus placebo to correct excessive anticoagulation in patients receiving warfarin: a randomized trial. Ann Intern Med. 2009;150:293-300. [PMID: 19258557] LinkGoogle Scholar2. Fang MC, Go AS, Hylek EM, Chang Y, Henault LE, Jensvold NG, et al. Age and the risk of warfarin-associated hemorrhage: the anticoagulation and risk factors in atrial fibrillation study. J Am Geriatr Soc. 2006;54:1231-6. [PMID: 16913990] CrossrefMedlineGoogle Scholar3. Schulman S, Beyth RJ, Kearon C, Levine MN; American College of Chest Physicians. Hemorrhagic complications of anticoagulant and thrombolytic treatment: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest. 2008;133:257S-298S. [PMID: 18574268] CrossrefMedlineGoogle Scholar4. Ansell J, Hirsh J, Hylek E, Jacobson A, Crowther M, Palareti G; American College of Chest Physicians. Pharmacology and management of the vitamin K antagonists: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest. 2008;133:160S-198S. [PMID: 18574265] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From University of Utah, Salt Lake City, UT 84108.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoOral Vitamin K Versus Placebo to Correct Excessive Anticoagulation in Patients Receiving Warfarin Mark A. Crowther , Walter Ageno , David Garcia , Luqi Wang , Dan M. Witt , Nathan P. Clark , Mark D. Blostein , Susan R. Kahn , Sara K. Vesely , Sam Schulman , Michael J. Kovacs , Marc A. Rodger , Phillip Wells , David Anderson , Jeffery Ginsberg , Rita Selby , Sergio Siragusa , Mauro Silingardi , Mary Beth Dowd , and Clive Kearon Vitamin K to Correct Overanticoagulation Ayad Jindeel Vitamin K to Correct Overanticoagulation P. Dileep Kumar Vitamin K to Correct Overanticoagulation Mark A. Crowther and David Garcia Vitamin K to Correct Overanticoagulation Mark W. Swaim and B. Gail Macik Vitamin K to Correct Overanticoagulation Vittorio Pengo , Gentian Denas , and Seena Padayattil Jose Metrics 15 September 2009Volume 151, Issue 6Page: 433-434KeywordsConflicts of interestDrugsHemorrhageSurgeryThoraxVitamin K ePublished: 15 September 2009 Issue Published: 15 September 2009 CopyrightCopyright © 2009 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...