tbuckley/cabot-search huggingface dataset:
SECONDARY TUMORS OF BONES.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Comments regarding the controversy of the "national" origin of the university in Prague
Authors: K. L. Terplan
Journal: JAMA (1966)

A short while back, a few letters were sent to the editor ofThe Journal(see also p 190 in this issue) regarding the University of Prague, which was founded by Charles IV in the year 1348. Some of these letters imply that the Charles University was from its very beginning a national Czech institution founded by the King of Bohemia, while others claim that Charles was at the same time a Roman king and emperor of the Holy Roman Empire and actually founded the university in his dual capacity as king of Bohemia and king of the Roman Empire. To the writer it appears somewhat unrealistic to try to interpret this historic event which took place more than 600 years ago in the latter half of the Middle Ages in terms of the modern connotation of the word "nationality." It was in one of the first gatherings of the
Prinzmetal Angina
Authors: L. Julian Haywood
Journal: JAMA (1976)

A 40-year-old man with severe angina had electrocardiographic changes typical of Prinzmetal angina during his attacks of chest pain. ST segment elevations in leads II, III, and aV<sub>F</sub>occurred intermittently with elevations in leads I and aV<sub>L</sub>, and with T wave flattening in V<sub>1</sub>, suggesting myocardial ischemia in areas supplied by the right coronary artery and by the circumflex branch of the left coronary artery. However, the coronary arteries appeared normal when arteriograms were made, suggesting that a reversible event caused the attacks. (<i>JAMA</i>235:53-56, 1976)
Medical schools in the United States and Canada
Journal: JAMA (1994)

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Editorial Board
Authors: James Field, Samuel Soskin, Beverly Hills, Garfield Duncan, Salman Azhar, Palo Alto, Hisham Barakat, George Bray, Jorge Calles-Escandon, Nc Charles, San Francisco, George Chrousos, Bernard Bethesda, St Davis, Leslie Louis, Frederick Degroot, Mario Derubertis, Atlanta Digirolamo, William Ga, Louis Duckworth, John Elsas, Kenneth Fain, San Feingold, Andrew Francisco, New Frantz, Gregory York, Saul Freund, Henry Cleveland, New Ginsberg, Charles York, Jane Glueck, Abbas Cleveland, Fredric Kitabchi, Stanford Kraemer, Robert Kraemer, Nelly Mauras, James May, Glenn Mortimore, Maria New, New York, Michael Pagliassotti, Ft Collins, William Pandak, Alan Richmond, Los Robinson, Peter Stacpoole, Richard Surwit, Marc Durham, John Tucson
Journal: Metabolism (2008)
Closing the Gaps in Health Insurance Coverage
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Laboratory and Human Studies on Polychlorinated Biphenyls (PCBs) and Related Compounds
Authors: Renate D. Kimbrough
Journal: Environmental Health Perspectives (1985)

Similar qualitative toxic effects have been observed in animals for a class of halogenated aromatic compounds, which include the halogenated biphenyls, naphthalenes, dibenzodioxins, and dibenzofurans.All of these compounds are lipid soluble and persist in the environment and in mammals.The polybrominated biphenyls (PBBs) are the most persistent.They are predominantly stored in fatty tissue; they pass the placenta and are excreted in milk.Some isomers of the halogenated biphenyls are more toxic than others.With some exceptions, the more toxic isomers are retained longer in tissues and are also the carcinogenic components of the mixture.Most of these chemicals seem to be promoters of carcinogenesis in animals rather than initiators.An array of toxic effects in laboratory animals has been ascribed to these compounds and numerous reviews summarizing this information are available.Less information is available on the human health effects of environmental and occupational exposure.Results of recent studies in animals to further elucidate the effects of these chemicals are presented, and results from some human studies conducted in the United States are reviewed.
Fee-for-service. Health Maintenance Organizations
Authors: R. H. Egdahl
Journal: JAMA (1979)

COST containment is now the nation's overriding priority in the issue of health care. The continuing increase in the percentage of gross national product devoted to health care and the continued stresses on state and federal budgets combine to ensure that the demand for effective control of health care costs will persist and probably escalate.<sup>1</sup>For the first time, the appropriate national allocation of expenses for medical diagnostic and treatment procedures is being seriously weighed against other pressing economic needs. The term "rationing" is being used increasingly in discussions of health care. Physicians' orders directly or indirectly account for some 70% of health care costs<sup>2</sup>and are, therefore, a logical focus of attempts to contain costs. Traditional insurance programs have failed to engage physicians, through direct financial incentives, in the difficult but necessary process of scrutinizing the massive expenditures they initiate. Traditional insurance programs have encouraged high-cost services
Prison
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A pilot study of preoperative (Pre-op), single-dose ipilimumab (Ipi) and/or cryoablation (Cryo) in women (pts) with early-stage/resectable breast cancer (ESBC).
Authors: Adi Diab, Heather L. McArthur, Stephen Barnett Solomon, Virgilio Sacchini, Christopher Comstock, Majid Maybody, Jeremy C. Durack, Brian Blum, Jianda Yuan, Sujata Patil, Deirdre A. Neville, Elizabeth Anne Comen, Elizabeth Ann Morris, Alan Kotin, Edi Brogi, Monica Morrow, James Patrick Allison, Clifford A. Hudis, Larry Norton, Jedd D. Wolchok
Journal: Journal of Clinical Oncology (2014)

1098 Background: Because intratumoral cryo with immune modulation generates a potent systemic anti-tumor immune response in murine models, this strategy may improve outcomes for women with ESBC. In this study, we evaluated the safety of pre-op cryo and/or ipi (10mg/kg) in ESBC pts and explored immune correlates including tumor infiltrating lymphocytes (TILs). Methods: Eligibility: age ≥18y with operable ≥1.5 cm invasive ESBC planning mastectomy (TM). Pts were sequentially assigned to receive pre-op: cryo alone (group A), ipi alone (B), or ipi and cryo (C). Tissue biopsies and/or cryo were performed 7-10d prior to TM. Ipi was administered 8-15d prior to TM (1-5d prior to cryo). The regimen was to be considered safe/tolerable if at least 5/6 pts in each group proceed to TM without delay. Toxicity evaluation continued for 30d after TM for group A and 12wks after ipi administration for groups B&C. Research peripheral bloods for immune correlates were obtained at baseline, biopsy, TM and 2-3 wks thereafter. Blood, biopsy and TM samples were evaluated by flow-cytometry. Results: The study is complete. Pre-op cryo-alone, ipi-alone and the combination were well tolerated and the primary safety endpoint was achieved with all 19 enrolled pts undergoing TM without delay. Group A was expanded to 7 pts after a possible technical failure in 1 pt, 6 pts enrolled to group B and 6 pts enrolled to group C. Median age was 48y (range 34-72y). Tumor necrosis/infarction was observed in 9/12 pts who underwent cryo. A trend toward an increased frequency of blood CD4+ICOS+, CD8+ICOS+, CD4+Ki67+ and CD8+Ki67+ T-cells was observed at TM compared with baseline in the ipi treated groups only. Analysis of TILs in the TM specimens suggested a higher ratio of CD8+Ki67+ T-cells to CD4+CD25+FOXP3+ (T-regulatory) cells in group C when compared with A&B. Conclusions: Pre-op cryo and ipi, alone or in combination, are safe/tolerable in pts with ESBC. Immune correlates revealed activation of T-cells in the blood in single-dose ipi treated pts and a modest increase in the ratio of tumor CD8+Ki67+ T-cells to T-regulatory cells after combination therapy only. A Phase II study of pre-op ipi and cryo in ESBC is planned. Clinical trial information: NCT01502592.
Functional health status levels of primary care patients
Authors: E. Nelson
Journal: JAMA (1983)

A cross-sectional study was conducted on functional status of adults visiting primary care practices. Limitations in physical and mental function were assessed independently in 28 practices by patients (N=1,227) and physicians (N=47) using a simple global index of disability. Results indicated 12% of patients rated their physical limitations as major and 8% rated major emotional limitations during the past month. Comparable assessments by physicians were 5% and 4%, respectively. Differences between patients and physicians were statistically significant and are demonstrated to be clinically relevant. Patients' functional limitations were associated with increased utilization of ambulatory care, older age, lower level of education, unemployment, and a primary diagnosis of a chronic condition. We conclude that functional status can be routinely recorded in medical practice to help describe severity, predict utilization, and improve the physician-patient relationship. (<i>JAMA</i>1983;249:3331-3338)
With current gene markers, presymptomatic diagnosis of heritable disease is still a family affair
Authors: B. Merz
Journal: JAMA (1987)

DNA SEQUENCES associated with heritable diseases are being identified with such regularity that molecular biologists appear to be operating a Gene-of-the-Month Club. In the last four years, genes or genetic markers have been identified for a host of disorders including Huntington's disease, cystic fibrosis, Duchenne muscular dystrophy, polycystic kidney disease, bipolar depressive disorder, retinoblastoma, Alzheimer's disease, and schizophrenia. Such discoveries have made it possible to diagnose in utero some 30 genetic diseases during the first trimester of pregnancy. Yet, while these newly discovered gene markers may be revolutionizing prenatal and presymptomatic diagnosis, they are in many respects halfway technology. Such was the opinion of several speakers at a conference sponsored by the American Medical Association in Washington, DC. At the conference, entitled DNA Probes in the Practice of Medicine, geneticists emphasized that gene markers—stretches of DNA that are usually inherited in tandem with a disease gene—are usually not sufficient for
Medical Science in Crime Detection
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Questions and Answers on Cancer
Journal: CA A Cancer Journal for Clinicians (1976)

CA: A Cancer Journal for CliniciansVolume 26, Issue 3 p. 181-185 DepartmentFree Access Questions and answers on cancer First published: May/June 1976 https://doi.org/10.3322/canjclin.26.3.181AboutSectionsPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat References 1 Laurant, J.; Debry, G., and Floquet, J.: Hypoglycemic tumours. Excerpta Medica, Amsterdam, 1971. Google Scholar 2 Marks, L. J.; Steinke, J.; Podolsky, S., and Egdahl, R. H.: Hypoglycemia associated with neoplasia. Ann. N.Y. Acad. Sci. 230: 147– 160, 1974. Wiley Online LibraryCASPubMedWeb of Science®Google Scholar 3 Kiang, D. T.; Bauer, G. E., and Kennedy, B. J.: Immunoassayable insulin in carcinoma of the cervix associated with hypoglycemia. Cancer 31: 801– 805, 1973. Wiley Online LibraryCASPubMedWeb of Science®Google Scholar 4 Castleman, B., and Kibbee, B. V.: Case records of the Massachusetts General Hospital. New Eng. J. Med. 268: 1129– 1139, 1963. Web of Science®Google Scholar 5 Hadfield, M. G.; Vennart, G. P., and Rosenblum, W. I.: Hypoglycemia: invasion of the hypothalamus by lymphosarcoma. Metastasis to blood glucose regulating centers. Arch. Path. 94: 317– 321, 1972. PubMedWeb of Science®Google Scholar 6 Unger, R. H.: The riddle of tumor hypoglycemia. Amer. J. Med. 40: 325– 330, 1966. CrossrefCASPubMedWeb of Science®Google Scholar 7 Levine, R. J., and Metz, S. A.: A classification of ectopic hormone-producing tumors. Ann. N.Y. Acad. Sci. 230: 533– 546, 1974. Wiley Online LibraryCASPubMedWeb of Science®Google Scholar 8 Unger, R. H.; Lochner, J. DeV., and Eisentraut, A. M.: Identification of insulin and glucagon in a bronchogenic metastasis. J. Clin. Endocr. 24: 823– 831, 1964. CrossrefCASPubMedWeb of Science®Google Scholar References 9 Mihm, M. C., Jr.; Clark, W. H., Jr., and From, L.: The clinical diagnosis, classification and histogenic concepts of the early stages of cutaneous malignant melanomas. New Eng. J. Med. 284: 1078– 1082, 1971. CrossrefPubMedWeb of Science®Google Scholar 10 Harris, M. N., and Gumport, S. L.: Total excision for primary malignant melanoma. J.A.M.A. 226: 354– 355, 1973. PubMedWeb of Science®Google Scholar Volume26, Issue3May/June 1976Pages 181-185 ReferencesRelatedInformation
INDIA
Journal: JAMA (1962)

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Hospital infection.
Journal: BMJ (1972)

Hospital InfectionToo many patients actually acquire infection while in hospital, and in a great variety of ways, among which new ones are still coming to light.An officially sponsored conference on nosocomial infections was held at the Center for Disease Control, at Atlanta in Georgia, in August 1970, and its proceedings have now been published.'The fact that nine of the foreign contributors were from Great Britain and only one from each of several other countries is a tribute to the effort which has been devoted in Britain to the study of this subject.It may be said to have originated here.since a sine qua non in tracing the spread of infection is to be able to suibdivide a species into as many identifiable types as possible, and this was first achieved in London by the late Frank Griffith in his studies of haemolytic streptococci.The conference dealt systematically with every aspect of its subject.Contributions on current national patterns came
Extraneous Sentence in the Abstract
Journal: JAMA Internal Medicine (2017)

Michihiko Goto, MD, MSCI; Marin L. Schweizer, PhD; Mary S. Vaughan-Sarrazin, PhD; Eli N. Perencevich, MD, MS; Daniel J. Livorsi, MD, MS; Daniel J. Diekema, MD, MS; Kelly K. Richardson, PhD; Brice F. Beck, MA; Bruce Alexander, PharmD; Michael E. Ohl, MD, MSPH
Education for the Health Services
Journal: JAMA (1949)

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