tbuckley/cabot-search huggingface dataset:
WORKSHOP: H PYLORI - IMMUNE RESPONSE INCLUDING VACCINES
Authors: H Pylori, N Dubois, E Fiala, G Incecik, M Perez-Perez, D Blaser, A Mccqlm, J Bagshaw, C Omalley, A Mclaren
Journal: Gut (1995)

Analyses of H. ylori colonization and virulence factors require models that closely match humans in terms of anatomy, physiology and genetics.Rhesus monkeys may meet this need.We report here the successful experimental infection of these monkeys by H. pylori strains of human as well as of monkey origin, and indications of differences among H. pylori strains in specificity for individual hosts.Five animals that were H. pylori negative by culture and histology, and a sixth animal that was later found to have a low grade H. pylori infection, were challenged with a mixture of 2 laboratory-passaged human strains and 1 monkey strain.Two ofthe five H. pylori-free animals, and "monkey 6" became persistently colonized after challenge, but the other 3 monkeys were not.Arbitrarily primed PCR DNA fingerprinting showed that all strains recovered from the first two monkeys, and most of those from "monkey 6" were of monkey origin.The exceptional isolates from "monkey 6" were closely related to its resident strain, but nevertheless distinguishable by a few RAPD bands.The 3 monkeys that had resisted the initial challenge were again challenged this time with two fresh human isolates, and each became colonized.In each case, DNA fingerprinting showed that colonization had been by only 1 of the 2 human strains.The successful colonization by a human strain of monkeys that had previously resisted colonization by a "monkey" strain suggests that individual H. pylori strains may be better suited for certain individual hosts, and that other strains may be best suited for other hosts.In this context, the special isolates from "monkey 6" that seemed to have diverged from the resident strain may have arisen by recombination between this resident strain and the input strain(s).Those new bacterial genotype(s) that were now better adapted to this individual host would then have been selected in the gastric mucosa.In conclusion, the present results show that monkeys can, indeed, be infected by H. pylori of human origin, and suggest that these animals will be very useful for understanding how bacterial genotype and host genotype, physiology and history of past disease, all affect whether a given exposure to H. pylori results in colonization and disease.
Pharmaceutical Dissolution of Gallstones
Journal: JAMA (1983)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Error in Results and in Table 3
Journal: JAMA Network Open (2019)

Violence in Video Games on Children's Dangerous Behavior With Real Guns: A Randomized Clinical Trial," 1 published May 31, 2019, the medians provided in the Time Spent Holding a Handgun and Trigger Pulls subsections of the Results section should have been described as adjusted medians.In Table 3, all the means (SEs) and medians (interquartile ranges) should have been labeled as adjusted.This article has been corrected. 1
Publisher Correction: Multi-trait analysis of genome-wide association summary statistics using MTAG
Authors: Patrick Turley, Raymond K. Walters, Omeed Maghzian, Aysu Okbay, James J. Lee, Mark Alan Fontana, Tuan Anh Nguyen-Viet, Robbee Wedow, Meghan Zacher, Nicholas A. Furlotte, Patrik Magnusson, Sven Oskarsson, Magnus Johannesson, Peter M. Visscher, David Laibson, David Cesarini, Benjamin M. Neale, Daniel J. Benjamin
Journal: Nature Genetics (2019)
The puberty that almost wasn't: helping men mature
Authors: E. R. Gonzalez
Journal: JAMA (1982)

A few adult men have recently gone through puberty for the first time, as a result of intermittent therapy with luteinizing hormone-releasing hormone (LHRH). These men "generally look like 12-year-olds," says Andrew R. Hoffman, MD, assistant professor of medicine at Stanford University School of Medicine, California. They are beardless, lack muscle mass, and have genitals one half to one third the normal adult size. They tend to live "celibate, almost monastic lives," Hoffman adds. "It's very sad," he elaborates. "They don't date women because of the fear that they will be asked to perform sexually, and they obviously can't. And they usually stop buddying around with men by the time they're 17 or 18 because it's embarrassing to go into a locker room." The men's problems result from idiopathic hypogonadotropic hypogonadism—in most cases congenital—so called because, for unknown reasons, the hypothalamus does not secrete LHRH in sufficient quantities, or in
DRUG MANUFACTURERS AS MEDICAL TEACHERS.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
HIV-Infected Patients Participating in Autologous Blood Programs
Authors: Robert G. Hoff
Journal: JAMA (1993)

<h3>To the Editor.</h3> —The recent article by Mintz<sup>1</sup>makes some interesting and valid points about the issues surrounding the collection of autologous blood from persons who are infected with blood-borne pathogens such as the human immunodeficiency virus (HIV). The points that he raised could easily be extended to individuals who are infected with hepatitis B, because many autologous programs do not collect blood from such individuals. The problem, however, with Mintz's article is that it focuses on the wrong transfusion issues for HIVinfected persons. Because of anemia many HIV-infected persons would not meet the hemoglobin standards for autologous donation and would be disqualified on that criterion alone. Second, 40% to 60% of autologous donations are never transfused to the originally intended recipient.<sup>2</sup>The reason is that most autologous units are collected prior to surgical procedures or for conditions that do not routinely require blood transfusion (eg, cholecystectomy, hysterectomy,
TWO NEW AMERICAN JOURNALS
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Biliary, as Well as Urinary, Calculi Become the Targets of New, Improved Shock Wave Lithotripsy
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Chlamydia pneumoniae and inflammatory markers in acute coronary syndrome: 12 months outcome Harish R. Chandra, Nivedita Choudhary, Carol O'Neill, Marcus J. Zervos, Judith Boura, Gerald C. Timmis, William W. O'Neill. William Beaumont Hospital, Royal Oak, MI
Journal: Journal of the American College of Cardiology (2001)
MEDICAL CONSIDERATION OF THE METHODS OF PUBLIC EDUCATION.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Food for Thought
Authors: Joseph D. Wassersug
Journal: JAMA (1988)

Knowing that I had been invited to a drug company—sponsored lecture cum gourmet dinner, a couple of my colleagues asked me if I would drive them to the affair, since they were both hesitant about driving at night. They were in their mid80s while I, at that time, was a mere youngster of 74. Compared with them, I still had some of the bravado of my youth. So, I was the chauffeur while my two old friends sat in the back seat discussing, mostly, the state of their health. Both of them admitted to being in good health and requiring no special medicines or treatments. Both were almost smug in their self-satisfaction in having been able to maintain an active medical practice for more than 50 years. What worried them most, however, was their mode of dying. Each confessed to having prayed fervently and frequently for a quick and easy
Preoperative determination of the surgical procedure for hepatectomy using technetium-99m-galactosyl human serum albumin (99mTc-GSA) liver scintigraphy
Authors: A Kwon
Journal: Hepatology (1997)

Technetium-99m-diethylenetriaminepentaacetic acidgalactosyl human serum albumin (Tc-GSA) is a new liver scintigraphy agent which binds to the asialoglycoprotein receptors. We evaluated the preoperative assessment for hepatectomy using Tc-GSA liver scintigraphy. Ninety patients with hepatocellular carcinoma were admitted for elective hepatectomy. Tc-GSA scintigraphy was conducted after the intravenous injection of Tc-GSA, and maximal removal rate of Tc-GSA (GSA-Rmax) was calculated using a radiopharmacokinetic model. Measurement of GSA-Rmax, conventional liver function, and 15-minute retention rate of indocyanine green (ICGR15) was carried out preoperatively. The relationships between liver functions, histological activity index (HAI), ICGR15, and GSA-Rmax values were estimated. A significant correlation was obtained between GSA-Rmax and ICGR15 (r = .534, P < .0001). Preoperative discrepancies between GSA-Rmax and ICGR15 values were seen in 15 patients. In these cases, the GSA-Rmax values correlated well with the total HAI scores (r = .595, P < .02), but no significant correlation was seen between the ICGR15 and HAI scores. Two patients died of postoperative liver failure within 2 months of the operation. These two patients were found to have severe discrepancies between their preoperative GSA-Rmax and ICGR15 values. We concluded that GSA-Rmax might be useful for selecting candidates for hepatectomy and that extended hepatectomies (di- and tri-segmentectomy) are high-risk surgical procedures in the case of low GSA-Rmax scores (below 0.35).
Chairman's Message
Authors: Dan Tunstall Pedoe
Journal: British Journal of Sports Medicine (1989)

money and encouraged a foreign attendant to inject British performers with, believe it or not, an intramuscular nostrum of ox-blood and honey.This sort of medievalism must be changed.We have many excellent team doctors-but, clearly, we need urgently to raise the public image of sports medicine to the level where our sportsmen and women can take responsible care for granted.
Notices
Authors: Petr Hulek, B Rau
Journal: Hepatology (2003)

Hepatology Meeting 2003 will be focused on clinically significant stages in hepatology.Leading speakersoutstanding hepatologists from Europe and the United States-will present in ten program blocks new ideas and suggestions on pathophysiology, diagnostics, and therapy of liver diseases.Main topics include Cirrhosis, Guidelines in Hepatology, Cholestasis, Acute Liver Failure, Indications for LTx, Techniques of LTx, Complications of LTx, Fibrogenesis, Viral Hepatisis B, and Viral Hepatitis C.Lower registration fees will be granted to early registering participants and young doctors.
Antithrombin III supplementation reduces heparin requirement and platelet loss during hemodialysis of patients with fulminant hepatic failure
Authors: P Langley
Journal: Hepatology (1991)

Previous studies have shown that antithrombin III levels are low in fulminant hepatic failure, and heparin kinetics are abnormal, making control of heparinization difficult during hemodialysis of these patients who are at risk of bleeding. In this study, we have performed a controlled, randomized trial of antithrombin III supplementation on heparin activity, occurrence of bleeding and the platelet count and activation during hemodialysis in 24 patients with fulminant hepatic failure. The treated group of 12 patients was given 3,000 units of antithrombin III before hemodialysis. Antithrombin III supplementation was shown to normalize antithrombin III levels during hemodialysis (prelevels: 0.22 ± 0.03 U/ml S.E.; at 1 hr 0.99 ± 0.06 U/ml; p <0.001; control prelevels: 0.24 ± 0.03 U/ml; at 1 hr 0.23 ± 0.04 U/ml). Total heparin usage was significantly decreased by antithrombin III supplementation (median 5,200 U; range = 2,005 to 13,000) as compared with the control group (median 10,200 U; range = 5,000 to 16,500; p <0.005). Blood heparin level (antifactor Xa activity) after the initial bolus was significantly greater in the antithrombin III—supplemented subjects (0.40 ± 0.07 U/ml compared with 0.22 ± 0.05 U/ml in the control group; p < 0.05). The significant reduction in platelet count observed in the control patients (18% ± 6% at 1 hr; p < 0.05) did not occur in antithrombin III patients (6% ± 4% at 1 hr), which was reflected by a lower release of the platelet-specific protein β-thromboglobulin. Two of 12 patients in both groups showed minor bleeding around vascular access sites during the first hemodialysis. Over the course of the study, no significant difference was seen in the frequency of bleeding from vascular access sites, gastrointestinal tract or other locations. Thus in a controlled study, supplementation of antithrombin III markedly reduced the amount of heparin required during hemodialysis of patients with fulminant hepatic failure and also reduced platelet losses. Antithrombin III supplementation may be of benefit in hemodialysis, continuous arteriovenous hemofiltration or other invasive techniques requiring anticoagulation in these patients at particular risk of bleeding. (HEPATOLOGY 1991;14:251–256.)
Plasma Ghrelin paradoxically rises upon feeding in active Crohn's disease
Authors: G. Moran, J. McLaughlin
Journal: Gut (2011)

<h3>Introduction</h3> Ghrelin is an orexigenic hormone. Circulating levels normally rise between episodes of food ingestion and then fall upon eating. Ghrelin may also be a signal to prime the gut for nutrient absorption. An anti-inflammatory role has also been proposed. A single previous report has suggested an increase in plasma fasting acylated ghrelin expression in active inflammatory bowel disease (IBD), with levels returning to normal once the disease is in remission. The postprandial response of ghrelin in intestinal inflammation has never been described. <h3>Methods</h3> 21 patients with active Crohn9s disease (CD) and 12 healthy controls were recruited. Disease activity was classified through independent histopathological/endoscopic assessments, validated patient questionnaires and biochemical scores. Gut hormone responses to a mixed nutrient test meal were studied using a multiplex ELISA technique (Luminex). Patient symptoms were assessed using a validated visual analogue score (VAS). A subgroup of patients who achieved remission (without surgery or anti-TNFα treatment) was also re-studied later. <h3>Results</h3> CD patients with active inflammation displayed a ∼6-fold significant reduction in basal appetite parameters as measured by VAS (p &lt; 0.0001). The pattern of the postprandial ghrelin response was paradoxically altered in the CD group with a rise noted postprandially. In the control group ghrelin levels displayed the expected drop after the test meal. Consequently, acylated ghrelin levels were higher in the CD group with a 3-fold increase noted in the total ghrelin level after the test meal. A significant correlation (p = 0.019) was noted between the total acetylated ghrelin secreted and the Crohn9s Disease Activity Index. A significant correlation also existed between ghrelin secretion and stool frequency (p = 0.01), more so in the SB CD group (p = 0.004). There was a significant negative correlation noted between the abdominal pain scores in the visual analogue score specifically in the SB CD group (p = 0.0008). After treatment of CD, the VAS reverted to those of normal controls and ghrelin responses to the test meal now showed a postprandial fall, as expected physiologically. <h3>Conclusion</h3> Ghrelin levels show an unexpected rise in response to a test meal in ileal CD. Ghrelin is not expressed in the healthy distal small bowel. It is now necessary to explore whether inflammation induces its expression there, or whether gastric secretion of ghrelin is somehow amplified at a distance. In intestinal inflammation, it may be that ghrelin assumes more its secondary role, that of an anti-inflammatory peptide. This plays a protective role when the antigen load of a meal is presented to the inflamed gut. The changes noted after treatment tend to corroborate this. Its postprandial response may also present a useful novel biomarker of disease activity.
No obvious reason for HBV double hit
Authors: C. Marwick
Journal: JAMA (1983)

Complete clinical recovery from active hepatitis B (HBV) viral infection is no guarantee that the disease will not recur if the experience of a group of investigators at the National Institutes of Health (NIH) is any guide. Of 25 patients seen at the NIH's Clinical Center with a history of chronic HBV infection, all of whom were deemed to have made a complete recovery, eight subsequently redeveloped active disease—apparently spontaneously. The finding adds yet another element of mystery to the still-unfolding story of HBV. "It is a new and distinct phenomenon that may have serious implications concerning the prognosis and progression of liver disease in these patients," Gary L. Davis, MD, told the annual meeting of the American Gastroenterological Association in Washington, DC. Davis is with the Liver Diseases Section, Digestive Diseases Branch, National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases, Bethesda, Md. Reactivation of hepatitis B has been
Current Comment
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal