tbuckley/cabot-search huggingface dataset:
The Physicians Who Care plan. Preserving quality and equitability in American medicine
Authors: R. S. Bronow
Journal: JAMA (1991)

THE AMERICAN health care system is under siege. The costs of advanced technology continue to overwhelm any short-term savings from managing care. This has led to a crisis situation, creating a need to develop new policies immediately.<sup>1</sup> During the past several years, it has been generally agreed on that we must expand access to health care to all Americans. But how? The issue is whether we should build on the existing employer-based and private insurance system or abandon it and replace it with a taxpayer-financed system. Concerned parties across the country are now choosing sides. One side argues that, in order to guarantee health care access to all, we should have a national health care program based on the Canadian system.<sup>2</sup>It is the belief of Physicians Who Care that such a program will not work in the United States.<sup>3</sup> We propose, instead, an extensive reshaping of
Gastrointestinal response to food
Authors: Mccullough Js, Carr Ke, B Ratcliffet, N Mandir2, Ra2 Goodlad, S Lewis, K Heaton
Journal: Gut (1996)

Conventional and germ-free rats were fed a fibre-free diet with or without the addition of a mixture of fermentable dietary fibres.Intestinal epithelial crypt cell production rates in the colon were dramatically increased by fibre, but only in the conventional group, suggesting that it is the breakdown of fibre by the colonic microflora that is responsible for its proliferative actions in the hind gut.Morphometrical analysis demonstrated that fibre also had direct effects on the number of crypts per circumference, and the number of goblet cells per crypt in the colon.The total number of goblet cells was also influenced by the presence of bacteria.Significant effects of fibre and bacteria on muscle nuclei were also observed, suggesting a direct effect of fibre on muscle mass.There was a large increase in the number of branched crypts (Crypt Branching Index) in the mid colon of the germ free rats (32.4% ±9.5 vs 7.6 ±1.7; P<0.001 (mean ± SEM n=15)), with little effect of fibre being observed.Crypt branching can lead to the production of new crypts -if they go on to fission, and this may be mediated by the disregulation of cell adhesion.Crypt branching may thus be an important process in the development of, or clonal expansion of, carcinogenesis.However. the large number of branched crypts seen in the aerm-free rats suggests that not all crypts have to undergo crypt fission, and that crypt branching does not necessarily equate with crypt fission.
Studying Hyperactive Children With Unique Monitoring Device
Journal: JAMA (1983)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Survey of American Chemistry. Volume I. July 1, 1925, to July 1, 1926. Including Reports from Scientific Committees, Division of Chemistry and Chemical Technology, National Research Council.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mass media campaign on folic acid did not alter socioeconomic differences
Journal: BMJ (1999)

Community exercise classes help people with back painAlthough patients with back pain should return to normal activities as soon as possible, many are afraid of further injury or making their pain worse and therefore reduce their activities.This can lead to chronic disability.Klaber Moffett et al (p 279) show that referring patients to a progressive exercise programme of eight evening sessions led by physiotherapists helped patients to cope better with their pain and function better.The benefits were maintained for at least a year, and patients' initial preferences for type of management did not affect outcome.Coxiella burnetii infection may be linked to cardiovascular disease
Primary Hyperparathyroidism
Authors: Arthur Hecht
Journal: JAMA (1975)

The serum calcium level measured in the research laboratory was 10.8 mg/100 ml or more in all of 73 patients with primary hyperparathyroidism, though many of the values were normal when measured in the hospital laboratories. Postoperatively, all patients successfully operated on showed an immediate increase in renal phosphorus reabsorption to 95% to 100%, and a decrease, which averaged 54%, in urinary hydroxyproline levels. Seven patients who had hyperplasia had no clinical or laboratory features distinguishing them from those with adenomas. Uremia, an ominous sign, was found in six patients, five of whom died. (<i>JAMA</i>233:519-526, 1975)
Abstract 737: NF-κB pathway activation by clonal mutations contributes to the recurrence of nasopharyngeal carcinoma
Authors: Rui You, You-Ping Liu, Ming-Yuan Chen
Journal: Cancer Research (2019)

Abstract Objectives: Identification and characterization of the genomic features that potentially drive NPC recurrence. Methods: We performed whole-genome/whole-exome sequencing of fresh tumors and corresponding blood samples from 55 rNPC and 44 pNPC patients. Additionally, previously published pNPC exome data were integrated for analysis. Immunohistochemistry and histologic analyses were performed to identify novel biomarkers among the differential mutational events between pNPC and rNPC in independent cohorts of 148 rNPC and 237 pNPC samples with complete clinical follow-up. Results: rNPC and pNPC tissues had similar mutational burdens; however, the number of clonal mutations was increased in rNPC samples. TP53 and three NF-κB pathway components (TRAF3, CYLD and NFKBIA) were significantly mutated in both pNPC and rNPC. Notably, mutations in TRAF3, CYLD and NFKBIA were all clonal in rNPC; however, 55.6-57.9% of them were clonal in pNPC (P &amp;lt; 0.05). In general, the number of clonal mutations in NF-κB pathway-associated genes was significantly higher in rNPC than in pNPC (P &amp;lt; 0.05). Moreover, the nuclear abundance of NF-κB protein was significantly greater in pNPC samples with local regional relapse than in those without relapse (P = 0.006). Further, in both the pNPC training and validation cohorts, high nuclear NF-κB levels were an independent negative prognostic marker for locoregional relapse-free survival (LRRFS) in pNPC. Accordingly, concurrent chemotherapy for patients with high nuclear NF-κB reduced the rate of locoregional relapse. Lastly, we functionally validated that inhibition of NF-κB enhanced both radiosensitivity and chemosensitivity in NPC cells, strongly supporting our in vivo results. Conclusion: NF-κB pathway activation by clonal mutations plays an important role in promoting the recurrence of NPC. Moreover, nuclear accumulation of NF-κB is a prominent biomarker for predicting LRRFS and suggesting treatment for pNPC patients. Finally, blocking NF-κB activity may be a novel and effective therapeutic modality for treating NPC. Citation Format: Rui You, You-Ping Liu, Ming-Yuan Chen. NF-κB pathway activation by clonal mutations contributes to the recurrence of nasopharyngeal carcinoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 737.
Thioacetamide Hepatocarcinogenesis&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Authors: F F Becker
Journal: JNCI Journal of the National Cancer Institute (1983)

Thioacetamide (TAA) was administered to inbred male ACI rats for 1 year to determine its hepatocarcinogenicity. The carcinogen was fed at a level of 0.035% in a semipurified diet so that other components could be manipulated. The following groups were used: group I, TAA alone; group II, TAA with riboflavin content at 0.002% (one-third of the daily requirement); group III, TAA plus a supplement of 0.05% crude bovine thyroid; and group IV, TAA, 0.002% riboflavin, and thyroid supplement. All groups demonstrated cirrhosis, neoplastic nodules, and cholangiofibromas to varying degrees. Group IV was invariably the most advanced in all lesions, while group II demonstrated the next most advanced picture of cholangiofibromas. These lesions persisted for 1 year after cessation of the diet. Primary hepatocarcinomas (PHC) were produced by groups I, III, and IV, with the highest number being in group IV. Group II evoked only primary cholangiocarcinomas (PCC). A number of both types of carcinomas transplanted successfully. Thus TAA appears to be a hepatocarcinogen capable of inducing either PHC or PCC, with the tumor type evoked somewhat dependent on the associated diet.
Correction to: Targeting TR4 nuclear receptor suppresses prostate cancer invasion via reduction of infiltrating acrophages with alteration of the TIMP-1/MMP2/MMP9 signals
Authors: Xianfan Ding, Dong-Rong Yang, Liqun Xia, Bide Chen, Shicheng Yu, Yuanjie Niu, Mingchao Wang, Gonghui Li, Chawnshang Chang
Journal: Molecular Cancer (2020)

An amendment to this paper has been published and can be accessed via the original article.
A PROBLEM IN ELIMINATION.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Messengers
Authors: Michael V. Slayter
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The ultimate consumer in nuclear medicine. The nuclear pioneer lecture of the Society of Nuclear Medicine, 1969, honoring Herrman L. Blumgart, MD
Authors: M. Brucer
Journal: JAMA (1969)

Herrman Blumgart (born Newark, NJ, 1895; SB 1917; MD 1921; honorary SD 1962; Harvard University) interned at Peter Bent Brigham Hospital, Boston. After a fellowship in London, he entered academic medicine on the Harvard Service at the Boston City Hospital and joined the staff of Beth Israel Hospital. In 1946 he became professor of medicine at Harvard, physician-in-chief and director of medical research at Beth Israel. In 1962 he retired to emeritus status, but continues to serve as special consultant. Dr. Blumgart, with many students and colleagues, has published 162 scientific articles, primarily in cardiology. In 1946 he introduced radioiodine for the treatment of intractable cardiac disease as an improvement over his trials, during the 30's, of surgically induced hypometabolism. In 1931 he summarized six years of work on the velocity of blood flow that involved Geiger chambers four years before the G-M tube, a natural radioactive tracer ten years before artificially produced radioactivity, production of a radiopharmaceutical 28 years before a radiopharmaceutical industry; and he was practicing nuclear medicine 30 years before its Society was founded. In 1969, for its tenth annual selection, the Society of Nuclear Medicine named the first physician, Dr. Blumgart, to its Honor Roll of Nuclear Pioneers.
Committee Leaders Omitted, Report Available
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Highlights
Journal: JAMA (2014)

Hypothermia reduces death or disability in neonatal hypoxic ischemic encephalopathy.In a randomized clinical trial that enrolled 364 full-term infants with hypoxic ischemic encephalopathy, Shankaran and colleagues found that compared with hypothermia at 33.5°C for 72 hours, longer duration (120 hours), deeper cooling (32.0°C), or both did not reduce rates of neonatal intensive care unit death.In an Editorial, Robertson and Marlow discuss hypothermia for perinatal hypoxic ischemic encephalopathy.
Reproductive mortality.
Authors: R A Wiseman
Journal: BMJ (1979)

Surely the classical process is from the general to the particular, and by going from the particular to the general they have got the process upside down.Either disease is a "unified concept" or it is not a concept at all.To end with I will ask two questions.How do they define the corresponding concept health?Is it possible that we are all, lay and professional alike, pursuing a mirage in our National Health Service ?
Correction
Authors: D Oppenheimer, W Ormerod, G Rushworth, P Blackett, A Blake, R Murray, F Albert-Recht, A Watt, I Olson, R Johnston, J Smith, R Downie, Bryan Kennedy, W Lumsden, Mary Macdonald, R Inkster, A Williams, Mr Kessel, Alistair Munro, Maxwell Jones, R Porter, D.-Marjorie Barry, H Devlin, R Emerson, I Diploma, Obstetrics.- K Ahmed, M Baruah, J Khanum, B Shah, S Geraghty, Mary O'connor, D Part, Helen Lloyd, Elizabeth Luke
Journal: BMJ (1963)
Cracow Contributions
Authors: Walter K. Frankel
Journal: JAMA (1964)

<h3>To the Editor:—</h3> The contributions in recognition of the 600th anniversary of the Cracow School of Medicine (<i>JAMA</i><b>188:</b>662, 668 [May 18] 1964) were thought-provoking. Drs. Tochowicz and Nowak state that by 1553 the salt miners of Wieliczka had occupational medical care. Actually, Paracelsus' father was a physician in the Fugger mines in Carinthia about 50 years earlier, and there the young Paracelsus learned about "Bergsucht," the mining disease later described by Agricola in<i>De Re Metallica</i>, which Herbert Hoover and his wife translated in 1912. In his stimulating contribution on Copernicus, Dr. Skulimowski mentions that "Cracow University at the end of the 15th century attracted young men from Germany...." In the 17th century Engelbert Kaempffer, a native of the German principality of Lippe, studied medicine at Cracow and later was a physician for the Dutch East India Company in Batavia, Indonesia. From 1693 to 1699 he served in
Unexplained Severe Illness Possibly Associated With Consumption of Kombucha Tea—Iowa, 1995
Journal: JAMA (1996)

Kombucha tea is a popular health beverage made by incubating the Kombucha mushroom in sweet black tea. Although advocates of Kombucha tea have attributed many therapeutic effects to the drink (1-3), its beneficial and/or adverse effects have not been determined scientifically. During April 1995, cases of unexplained severe illness (including one death) occurred in two persons in a rural town in northwestern Iowa who had been drinking Kombucha tea daily for approximately 2 months. Based on the findings of a preliminary investigation by the Iowa Department of Public Health (IDPH), on April 10 IDPH issued a news release recommending that persons refrain from drinking Kombucha tea until the role of the tea in the two cases of illness had been evaluated fully. This report summarizes the investigation of these cases by the IDPH, CDC, and the Food and Drug Administration (FDA).
Possible reproductive detriment in LSD users
Authors: C. B. Jacobson
Journal: JAMA (1972)

One hundred forty women and their consorts, admitting to the use of lysergic acid diethylamide (LSD) prior to or during pregnancy were observed through 148 pregnancies. There were 83 live newborns; 8 had major congenital defects. There were 65 abortions; 53 therapeutic and 12 spontaneous. Four of 14 embryos from therapeutic abortions showed gross anomalies. Forty-three percent of first-trimester pregnancies ended in spontaneous abortions. Four of eight serial pregnancies resulted in defective embryos or infants. Eight of 12 women have been unable to conceive again over an 18-month period. The ingestion of other illicit drugs, the presence of infectious disease, and marginal maternal nutrition preclude a definitive correlation of increased reproductive risk with LSD ingestion. The presence of LSD ingestion, coupled with studies in animals and supported by DNA studies, suggests that LSD might be hazardous to human reproduction.
Syringomyelia
Authors: Elliot Wilner
Journal: JAMA (1967)

<h3>To the Editor:—</h3> The case of syringomyelia reported by Drs. Magee and Schneider (<b>200</b>:795, 1967) was certainly unusual and noteworthy for its unusual clinical finding of loss of deep pain with otherwise normal sensory perception. However, the theories which they propose to rationalize this finding strike me as less attractive than another theory which might be forwarded: The syrinx caused damage to the ventral spinothalamic tract, as well as to the adjacent ventral horn, but did not involve other sensory pathways (ie, lateral spinothalamic tract or dorsal columns). The ventral spinothalamic tract is believed to carry fibers subserving deep pain and pressure, and first-order fibers course for as many as eight segments up or down the cord in dorsal white matter before synapsing and decussating to form this tract.<sup>1</sup>Damage to this tract, then, might give dissociated loss of deep-pain sensation; and the fact that ventral spinothalamic fibers
Error in First Sentence of Results
Authors: Niek Achten, Claus Klingenberg, Frans Plötz
Journal: JAMA Pediatrics (2020)

Samir Soneji, PhD; Jessica L. Barrington-Trimis, PhD; Thomas A. Wills, PhD; Adam M. Leventhal, PhD; Jennifer B. Unger, PhD; Laura A. Gibson, PhD; JaeWon Yang, BA; Brian A. Primack, MD, PhD; Judy A. Andrews, PhD; Richard A. Miech, PhD; Tory R. Spindle, MS; Danielle M. Dick, PhD; Thomas Eissenberg, PhD; Robert C. Hornik, PhD; Rui Dang, PhD; James D. Sargent, MD