tbuckley/cabot-search huggingface dataset:
Performance of 45 laboratories participating in a proficiency testing program for Lyme disease serology
Authors: L. L. Bakken
Journal: JAMA (1992)

<h3>Objective.</h3> —We show that significant interlaboratory and intralaboratory variations exist in Lyme disease proficiency testing. <h3>Design.</h3> —Six case-defined Lyme serum samples and three serum samples from individuals with no history of Lyme disease were randomized in four shipments and distributed to 45 participating laboratories. <h3>Results.</h3> —Interlaboratory and intralaboratory performances were highly variable. Approximately 4% to 21% of laboratories failed to identify correctly positive serum samples with titers of 512 or more using polyvalent serum or immunoglobulin G conjugates. With lower levels of anti—<i>Borrelia burgdorferi</i>antibody in the serum sample, approximately 55% of participating laboratories did not identify a case-defined serum. There was also a striking inability of many laboratories to reproduce their results on split samples from the same individual. In addition, 2% to 7% of laboratories identified serum samples from individuals with no known exposure to<i>B burgdorferi</i>as positive using polyvalent serum. The false positivity rate increased to 27% with the use of immunoglobulin G conjugate. <h3>Conclusions.</h3> —Our results indicate that there is an urgent need for standardization of current testing methodologies. Until a national commitment is made, serological testing for Lyme disease will be of questionable value for the diagnosis of the disease. (<i>JAMA</i>. 1992;268:891-895)
Irish Dispensary Doctors
Authors: R. Abraham, J. T. Elliott, J. Gordon, R. Gray, J. Keating, H. C. Manley, R. H. Newett, R. D. Patterson, J. Patterson, J. R. Phillips, R. J. Roulston, P. M. Rice, W. J. Shee, H. Warnock
Journal: BMJ (1891)
Ammonia Neutralization and Urea Synthesis in Cardiac Muscle
Authors: V. N. Smirnov, G. B. Asafov, N. M. Cherpachenko, G. B. Chernousova, V. T. Mozzhechkov, V. I. Krivov, Iu. A. Ovchinnikov, V. G. Merimson, V. G. Rozynov, M. N. Chumachenko
Journal: Circulation Research (1974)
CANCER OF THE HEAD AND FACE.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Combination therapy for hepatitis B: 2 case presentations , Medical College of Ohio, Toledo, OH 43699
Journal: Hepatology (1995)

Murine erythroleukaemic cells were studied to determine whether different isoferritins have different functions. The cells were labelled with radioactive iron and the pattern of isoferritins was analysed by chromatofocussing. No changes was found after iron-loading the cells but after inducing erythroid differentiation with dimethyl sulphoxide (DMSO), iron was incorporated into both more basic and more acidic isoferritins. This was compared to ferritin subunit synthesis; DMSO induced the synthesis of a third, minor subunit whereas iron-loading had no effect. The fate of murine erythroleukaemic cell ferritin iron was followed after incubations in iron-deficient medium containing DMSO; some, but not all, of the ferritin iron was mobilized and used for haem synthesis, and the remaining iron was found amongst the more basic isoferritins. Finally, sequential radioactive iron labels were used to demonstrate that the movement of iron from ferritin to haem was compatible with the ‘last-in-first-out’ principle, but this could not be related to different isoferritins. These results show firstly that DMSO changes the pattern of isoferritins and ferritin subunits in murine erythroleukaemic cells. Secondly, iron associated with more basic isoferritins seems to be less easily mobilized for haem synthesis. These results support the concept that different isoferritins have different functions.
Patients probably measure their own blood pressure accurately
Journal: BMJ (1999)

H pylori is weakly associated with heart diseaseChronic infection with Helicobacter pylori may be an avoidable cause of coronary heart disease, but most studies have been too small and prone to bias to assess this reliably.Danesh et al (p 1157) report two of the largest case-control studies so far.A study of 1122 cases of early onset myocardial infarction (average age 44 years) and 1122 age and sex matched controls found that myocardial infarction is about twice as common in people with serological evidence of persistent H pylori infection than in others.A weaker trend was found in a separate study of 510 sibling pairs.The authors conclude that in the context of previously published studies, their results show a weak association between H pylori and early onset heart disease.
What's new in the other general journals
Authors: Christopher Martyn
Journal: BMJ (2006)

What is the best treatment for patients with acute myocardial infarction when thrombolysis fails? It's an important question because intravenous thrombolysis restores good blood flow in the infarct related artery in only about 60% of cases. Some doctors, especially in hospitals without interventional facilities, treat such patients conservatively. Another option is to try a second dose of a thrombolytic agent. Small trials have suggested that percutaneous coronary intervention is justified, but current guidelines recommend it only for high risk patients. Credit: N ENGL J MED The results of a multicentre trial in Britain now indicate that angioplasty is probably best for everyone. In the trial 427 patients in whom thrombolytic treatment had failed (judged by lack of ST segment resolution) were randomly assigned to repeated thrombolysis, conservative therapy, or emergency percutaneous coronary intervention. The primary end point was a composite of death, reinfarction, stroke, or severe heart failure within six months. Event-free survival was significantly better among patients assigned to rescue angioplasty, even though a substantial proportion of the patients treated in this way had to be transferred from hospitals without interventional facilities. In comparison with the group receiving repeated thrombolysis, their treatment was delayed by a median time of 84 minutes. There were no differences in rates of major bleeding complications between groups, although minor bleeding episodes, mostly at the access site, occurred in more than 20% of those treated percutaneously. N Engl J Med 2005;353:2758–2768 [OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] Age related macular degeneration is the commonest cause of irreversible blindness in elderly people. We know little about its causation, but—because the retina may be particularly susceptible to oxidative stress owing to its high concentrations of oxygen, polyunsaturated fatty acids, and photosensitisers—it's thought that levels of antioxidant vitamins may be important. A randomised controlled trial found that high doses of βcarotene, vitamins C and E and zinc tended … [1]: {openurl}?query=rft.jtitle%253DNew%2BEngland%2BJournal%2Bof%2BMedicine%26rft.stitle%253DNEJM%26rft.issn%253D0028-4793%26rft.aulast%253DGershlick%26rft.auinit1%253DA.%2BH.%26rft.volume%253D353%26rft.issue%253D26%26rft.spage%253D2758%26rft.epage%253D2768%26rft.atitle%253DRescue%2BAngioplasty%2Bafter%2BFailed%2BThrombolytic%2BTherapy%2Bfor%2BAcute%2BMyocardial%2BInfarction%26rft_id%253Dinfo%253Adoi%252F10.1056%252FNEJMoa050849%26rft_id%253Dinfo%253Apmid%252F16382062%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1056/NEJMoa050849&link_type=DOI [3]: /lookup/external-ref?access_num=16382062&link_type=MED&atom=%2Fbmj%2F332%2F7533%2F105.atom [4]: /lookup/external-ref?access_num=000234246700007&link_type=ISI
Abstract 1737: FoxO4 is an Atheroprotective Factor
Authors: Qing-Jun Zhang, Wen Zhou, Zhi-Ping Liu
Journal: Circulation (2008)

Atherosclerosis is a chronic inflammatory process of arterial wall as the result of interactions between genetic and environmental factors. The pathological change of atherosclerosis involves interactions of endothelial cells, smooth muscle cells and infiltrating immune cells including macrophages and T cells. We have found that one of the family members of FoxO transcription factor, FoxO4, plays important roles in the regulation of phenotype switch of smooth muscle cells, matrix remodeling, and immune cell recruitment. Based on these observations, we hypothesize that FoxO4 may regulate atherogenesis through one or more aforementioned processes. To test this hypothesis, we generated ApoE/Foxo4 double knockout mice (DKO). The ApoE/Foxo4 DKO mice and ApoE single knockout littermates (SKO) were fed with high fat diet for 8 weeks to induce atherosclerosis. At the end of the 8 weeks, the aortas and hearts were dissected out and plasmas were collected. The aortic plaque was stained with Oil Red O en face and the percentage of plaque area to aortic face area was determined. Results show that there was no difference of plasma cholesterol level between DKO mice and control group (2300 ± 414mg/L in ApoE group vs 2667 ± 344mg/L in ApoE/Foxo4 DKO group, p = 0.28). No body weight difference was observed between these two groups of mice neither before nor after high fat diet. ApoE/Foxo4 DKO mice developed significantly more atheroscle-rotic plaques than that of ApoE SKO littermate controls (6.28 ± 1.40 in ApoE SKO group vs 9.47 ± 2.59 in ApoE/Foxo4 DKO group, p = 0.0016), suggesting that FoxO4 is an atheroprotective factor. We are currently investigating the molecular mechanism(s) by which FoxO4 regulates atherogenesis. This research has received full or partial funding support from the American Heart Association, AHA National Center.
Immunology in Histoplasmosis
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
<i>Errata:</i>Vol. 65, No. 18
Journal: MMWR Morbidity and Mortality Weekly Report (2016)

In the report, "Progress Toward Polio Eradication - Worldwide, 2015-2016," on page 471, in Table 2, the title should have read "Number of reported poliovirus cases, by country - worldwide, January 1, 2015-May 4, 2016," and the heading for the second column should have been "2015 (January-December)."
Cytotoxic Effect of Asbestos on Macrophages in Different Activation States
Authors: Annette Wright, K. Donaldson, J. M. G. Davis
Journal: Environmental Health Perspectives (1983)

The in vitro effects due to phagocytosis of asbestos by mouse peritoneal macrophages in various stages of activation have been compared. The amphiboles proved relatively inert; chrysotile, however, expressed a greater degree of cytotoxicity toward those populations of macrophages induced in vivo with asbestos, than toward any of the other populations of cells. These results are compared with data concerning the enzyme release from the different populations of macrophages following phagocytosis of asbestos. The results indicate that those macrophages that have been exposed to a prior stimulation of either amphibole or serpentine asbestos in vivo are particularly sensitive to exposure to a second dose of a toxic fiber.
Transmission Of Signals From The T Lymphocyte Antigen Receptor To The Genes Responsible For Cell Proliferation And Immune Function: The Missing Link
Authors: K. Ullman
Journal: Annual Review of Immunology (1990)

Transmission of Signals from the T Lymphocyte Antigen Receptor to the Genes Responsible for Cell Proliferation and Immune Function: The Missing Link, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/immunol/8/1/annurev.iy.08.040190.002225-1.gif
ITALY
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Opiate Drugs and δ-Receptor–Mediated Myocardial Protection
Authors: Patrick E. Benedict, Mary B. Benedict, Tsung-Ping Su, Steven F. Bolling
Journal: Circulation (1999)

Background —Hypothermic myocardial arrest is necessary to complete most cardiac surgery, which limits the success of such operations. Similarly, cold, inhospitable environments limit the survival of warm-blooded animals. Animals have successfully adapted to this challenge through hibernation. Hibernation is an energy-conserving state, now known to be governed by cyclical variation in endogenous opiate compounds. It may also be induced in nonhibernators via hibernating animal serum factors or δ-opiate peptides. Furthermore, hibernation-induction triggers extend organ preservation in many models. This study examined whether opiate drugs with an affinity for the δ-opiate receptor confer similar protection. Methods and Results —Isolated hearts harvested from New Zealand White rabbits were treated with either cardioplegia alone or δ-opiate drugs (fentanyl, morphine, buprenorphine, pentazocine) followed by 2 hours of 34°C ischemia. Hearts were then reperfused, and functional and metabolic indices of treated groups were compared with untreated controls. Isovolumic developed pressure, coronary flow, and oxygen consumption were compared as a percent of preischemia versus 45 minutes after reflow. Developed pressure and oxygen consumption were better preserved in the morphine, buprenorphine, and pentazocine groups when compared with cardioplegia alone. Conclusions —Drugs with δ-opiate activity confer myocardial protection, which is additive to cardioplegia. Use of δ-opiate drugs in this context may have important clinical implications.
Cancer prevention.
Authors: J Horton
Journal: Journal of Clinical Oncology (1985)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1985.3.6.747 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 3859583 Cancer prevention. J HortonxJ HortonSearch for articles by this author https://doi.org/10.1200/JCO.1985.3.6.747 PDF "Cancer prevention.." Journal of Clinical Oncology, 3(6), pp. 747–748© 1985 by American Society of Clinical Oncology
Fluoxetine and Sexual Dysfunction
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
American Journal of Public Health, New York
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Image registration
Authors: D. J. Hawkes
Journal: Clinical Nuclear Medicine (1998)

Image registration has emerged as an important application of computational methodology in medical imaging, and particularly so in nuclear medicine. The process allows information derived from one imaging source to be related to information from another. In other application areas such as surveillance, defence and remote sensing this combination of information is often termed 'data fusion'. Image registration methodologies are also being applied to areas of medicine using technologies of virtual reality, augmented reality and telepresence in, for example, image-guided surgery and other interventions.KeywordsMutual InformationImage RegistrationRegistration ProcessRegistration AccuracyPoint LandmarkThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Trachoma with Diagnosis by Culture
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cavernous sinus thrombosis mimicked by CNS lymphoma
Authors: L. G. Crocker
Journal: JAMA (1966)

GENERALIZED LYMPHOMA is a disease which presents in many ways, including central nervous system (CNS) involvement. The present case displays not only an unusual neurological manifestation of lymphoma, cranial nerve involvement, but also shows that the disease process lymphoma can be difficult to diagnose. The reviews of the subject of CNS lymphoma mention the difficulty of diagnosis, and the rarity of lymphoma presenting with neurological symptoms.<sup>1</sup>Whisnant presented a case of a 45-year-old man with a left 6th nerve palsy and other cranial nerve involvement due to a reticulum cell sarcoma in the left cerebellopontine angle and middle fossa.<sup>2</sup>Sparling reported 118 cases of malignant lymphoma, 13 of which had brain involvement.<sup>3</sup>Abbott described a syndrome caused by lymphomatous tumors arising in the eustacian tube, and involving all the cranial nerves in the middle fossa.<sup>4</sup>Hutchinson studied 229 patients with lymphoma over a 20-year period, and