tbuckley/cabot-search huggingface dataset:
Risk of skeletal-related events (SREs) in patients with lung cancer (LC) and newly diagnosed metastases to bone.
Authors: Kathryn E. Richert-Boe, John Edelsberg, Charu Taneja, Lois Lamerato, Andrew Glass, Greg G. Wolff, Natalie Czapski, Karen Chung, Akshara Richhariya, Gerry Oster
Journal: Journal of Clinical Oncology (2012)

e18107 Background: Bone is a common site of metastatic involvement in patients (pts) with LC. Bony metastases (mets) are often associated with SREs (spinal cord compression [SCC], pathologic fracture [PF], surgery to bone [SB], radiotherapy to bone [RT]). Skeletal complications cause significant morbidity and mortality. Current estimates of SRE risk come principally from randomized clinical trials. Information from routine clinical practice is limited. Methods: Using the tumor registry and electronic data stores at a large U.S. Midwest healthcare system that serves approximately 800,000 persons, we retrospectively identified all pts aged ≥18 yrs with primary LC and newly diagnosed bone mets between 1/1/95 and 12/31/09. Electronic medical records were reviewed by trained abstractors for evidence of SREs between date of bone mets diagnosis and death, loss to follow-up, or end of study. Cumulative incidence of SREs was estimated in the presence of competing risk of death. Results: We identified a total of 272 pts with primary LC and newly diagnosed bone mets; 66 pts had evidence of SREs at initial diagnosis of bone mets and were excluded from the analyses. Among the remaining 206 pts, mean (SD) age was 65.7 yrs (10.5 yrs) and 66% were male; 47% were Caucasian and 50% were African-American. Median duration of follow-up after diagnosis of bone mets was 3.0 months (mos). At 6 mos, cumulative incidence of SREs was 45.6% (SCC, 6.9%; PF, 20.6%; SCC and/or PF, 25.0%; SB, 4.1%; RT, 34.7%) (Table). Corresponding figures at 12 mos were 50.8% (SCC, 6.9%; PF, 24.1%; SCC and/or PF, 28.3%; SB, 4.1%; RT, 39.8%). Relatively few pts (17.5%) received intravenous bisphosphonates prior to SRE. Conclusions: Pts with LC in routine clinical practice are at high risk of SREs following initial diagnosis of bone mets. [Table: see text]
Angiography
Authors: Franklin S. Alcorn
Journal: JAMA (1972)

This second edition of Dr. Abrams' well-known work represents a most complete compilation of the facts on arteriography existent under one title. In reviewing this I utilized the expertise of members of the Department of Diagnostic Radiology in the Presbyterian-St. Luke's Hospital. The section on the angiography of the head may well be the highlight of the entire volume. The chapters dealing with cerebrovascular anatomy have the same excellent photographs and beautiful line drawings used in the first edition. A considerable portion is devoted to the techniques and hazards of cerebral angiography and certainly should discourage the inexperienced from attempting these procedures without good instruction. In the section on thoracic aortography the authors have nicely presented the hazards involved in investigating aneurysms of the thoracic aorta as well as in evaluating dissecting aneurysms. The chapter on coronary arteriography is essentially a reprint of a two-article series in the<i>New England</i>
Phase III (COSMIC-312) study of cabozantinib (C) in combination with atezolizumab (A) vs sorafenib (S) in patients (pts) with advanced hepatocellular carcinoma (aHCC) who have not received previous systemic anticancer therapy
Authors: T. Yau, L. Rimassa, A.-L. Cheng, J.-W. Park, F. Braiteh, A. Chaudhry, F. Benzaghou, P. Thuluvath, S. Hazra, S. Milwee, B. Tan, R. Sinha, Z.K. Kayali, A.X. Zhu, R.K. Kelley
Journal: Annals of Oncology (2019)
Vascular lesions of cerebellum associated with lumbar intradural mass
Authors: B. J. Haskin
Journal: JAMA (1967)

Dr. Milton A. Weiner: A 22-year-old woman entered the hospital in 1964 with complaints of morning headaches, vomiting, and dizziness of several months' duration. There was a strong family history of Lindau-von Hippel disease involving numerous members of the family, including the patient's mother. At 17 years of age, she was found to have a hemangioma in the right eye which was treated by coagulation. Physical examination at the time of admission to the hospital in 1964 revealed papilledema, nystagmus, and some difficulty in coordination of her left hand. A cranial study and a left vertebral angiogram were obtained. <h3>Discussion</h3> Dr. Laurence L. Robbins: Dr. Hanelin, what is your opinion of these studies (Fig 1)? Dr. Joseph Hanelin: I would say this is a fairly typical hemangioblastoma. There is an area in the comparatively less-vascularized left cerebellar hemisphere which contains a highly vascularized nodule. This might be a cystic hemangioblastoma
BMA council 1987-8: craft nominees
Journal: BMJ (1986)

attended over 100 meetings appealing for the report to-be implemented in f.But if the conference rejected the report as a whole the -GMSC and the negotiators would-not have-its advice on some of the unportant aspects.--The.conference took his advice, moving on to insist that communty nursing should be practice based and rejecting the concept of neighbourhood nursing in the Cumberlege report.Norfolk attracted unanimous support for its motion emphasising that many of the improvements that had occurred inthe provision ofgeneral medical services were a direct result ofthe employment of-practice nurses.Because there were pro- cedures that district nurses were not able to do the practice nurses had been able to develop therskills and had become inportant members of the team, Dr A.J Lister said.He emphasis the loyalty that many practice nurses had for their primary health care team; because they were able to take on extra work he had more time to spend with patients.Dr Michael Wilson called for unanimous support for the motion because of the disgraceful way in which practice nurses had been attacked.The message should go out that general practitioners apprecated the support dtey had from their prac- tice nurses.On the Cumberlege report-the conference..-.* insisted that community nursing should be practice based.* rejected the concept of neighbourhoQd nursmg.* opposed the concept ofnurse practitioners until there was a clearer definition of their role and responsibility.* totally rejected the idea ofa formal writen agreement between general practitioners and attached members of the primary health care team.
Erratum: Corrigendum: A somatic-mutational process recurrently duplicates germline susceptibility loci and tissue-specific super-enhancers in breast cancers
Authors: Dominik Glodzik, Sandro Morganella, Helen Davies, Peter T Simpson, Yilong Li, Xueqing Zou, Javier Diez-Perez, Johan Staaf, Ludmil B Alexandrov, Marcel Smid, Arie B Brinkman, Inga Hansine Rye, Hege Russnes, Keiran Raine, Colin A Purdie, Sunil R Lakhani, Alastair M Thompson, Ewan Birney, Hendrik G Stunnenberg, Marc J van de Vijver, John W M Martens, Anne-Lise Børresen-Dale, Andrea L Richardson, Gu Kong, Alain Viari, Douglas Easton, Gerard Evan, Peter J Campbell, Michael R Stratton, Serena Nik-Zainal
Journal: Nature Genetics (2017)
Radium in General Practice.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Workshop on Culture of Human Mammary Tissue
Journal: JNCI Journal of the National Cancer Institute (1973)

Workshop on Culture of Human Mammary Tissue Get access JNCI: Journal of the National Cancer Institute, Volume 50, Issue 5, May 1973, Pages 1407–1410, https://doi.org/10.1093/jnci/50.5.1407 Published: 01 May 1973
PP-006 The gut in health and disease: scenting the difference by “electronic nose”
Authors: R P Arasaradnam, N Quraishi, S Kumar, C Nwokolo, K D Bardhan, J Covington
Journal: Gut (2010)

<h3>Introduction</h3> Resident colonic bacteria (anaerobes and firmicutes) ferment undigested fibre. The balance between their large species number is influenced by the host genetic make up. An individuals “fermentation profile” (FP) is therefore likely to comprise a stable “personal signature” and a variable portion, which is influenced by the gut environment—diet and to a lesser extent drugs, thus offering an insight into colonic microbial health. A method of monitoring FP is by analysing the gaseous release that emanates off a patient9s urine or faecal sample. This can then be characterised using various techniques, but two options are: Artificial olfaction (the so called electronic nose or e-nose), which offers a method to rapidly identify disease groups based on the a complete “bio-odorant signature”; Gas Chromatography/Mass Spectrometry, which seeks to identify all the chemical components within a sample. <h3>Aim</h3> Pilot study using an “e-nose” to determine if disease groups can be distinguished and identified from faeces and urine samples. <h3>Methods</h3> Subjects and patients: two healthy (normal) volunteers; Ulcerative Colitis (n=1; active disease induced into remission), Crohns Disease (n=1). Biological samples of faeces and urine were collected and urine samples were analysed. Samples were prepared in universal containers (10 ml) and heated to 38±0.1°C. The headspace (the air above the sample) was then analysed using a Cyrano A320 (Smith Detection) e-nose, employing 32 carbon black compositae chemoresistive chemical sensors. These instruments employ a series of sensors with overlapping sensitivity, thus creating a “fingerprint” of the total chemical composition of a sample (as with the human nose). Each headspace was sampled for 30 s, and purged for a further 30 s in laboratory air. The differential response between the sample and the background air was used for analysis. <h3>Results</h3> The PCA plot generated (not shown; high resolution) demonstrates the e-nose9s capability to distinguish between disease groups with &gt;90% selectivity. Specifically there was polarity between UC and CD subjects and importantly, shifting of profile in the UC subject with treatment towards a normal configuration. <h3>Conclusion</h3> 1. The e-nose offers a rapid and promising way of investigating FPs in health and disease. 2. Clear differences in gaseous profile between volunteers and disease subjects were demonstrated. 3. The gaseous profile changes with treatment. The study of FPs using e-nose is novel and offers a new insight into “scenting” gut health.
1966 Medical Disciplinary Report
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 548: Evaluation of novel SIRP antibodies as potential cancer therapeutics
Authors: Ronald R. Hiebsch, Myriam N. Bouchlaka, Benjamin J. Capoccia, Michael J. Donio, Prabir Chakraborty, W. Casey Wilson, Robyn J. Puro, Daniel S. Pereira
Journal: Cancer Research (2019)

Abstract Targeting immune checkpoints of adaptive immunity has shown great therapeutic efficacy in oncology, but in a limited fraction of patients. Innate immune cells represent the most abundant immune cell types in many solid tumors and are often linked to a poor prognosis. SIRPα is expressed by innate immune cells and its interaction with CD47, expressed by most tumor cells, is an important immune checkpoint of the innate response, involved in the regulation of phagocytosis by macrophages, dendritic cells and neutrophils. Recently, first generation agents targeting CD47 (CD47 antibodies and SIRPα-Fc fusion proteins) have shown promise in clinical trials, but they have also experienced hematological toxicities such as anemia or thrombocytopenia. Consequently, we have previously reported on the development of AO-176, a next generation anti-CD47 antibody that not only blocks the CD47/SIRPα interaction and induces phagocytosis, but also preferentially binds tumor versus normal cells (including RBCs where it binds negligibly) and directly kills tumor cells via a programmed cell death type III and an immunogenic cell death process. Here we report the discovery of novel anti-SIRP antibodies that recognize either SIRPα selectively or SIRPα/γ. These antibodies are being evaluated for their ability to induce phagocytosis of tumor cells - we have identified antibodies that induce phagocytosis of tumor cells alone and in combination with Rituxan. The ability of our anti-SIRP antibodies to induce immunomodulatory activities in a variety of ex vivo cultured immune cells expressing either SIRPα or SIRPα/γ is also under investigation and will be presented. Citation Format: Ronald R. Hiebsch, Myriam N. Bouchlaka, Benjamin J. Capoccia, Michael J. Donio, Prabir Chakraborty, W. Casey Wilson, Robyn J. Puro, Daniel S. Pereira. Evaluation of novel SIRP antibodies as potential cancer therapeutics [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 548.
miR-22 represses cancer progression by inducing cellular senescence
Authors: Dan Xu, Fumitaka Takeshita, Yumiko Hino, Saori Fukunaga, Yasusei Kudo, Aya Tamaki, Junko Matsunaga, Ryou-u Takahashi, Takashi Takata, Akira Shimamoto, Takahiro Ochiya, Hidetoshi Tahara
Journal: The Journal of Experimental Medicine (2011)
Determination of Monomethylarsonous Acid, a Key Arsenic Methylation Intermediate, in Human Urine
Authors: X. Chris Le, Mingsheng Ma, Xiufen Lu, William R. Cullen, H. Vasken Aposhian, Baoshan Zheng
Journal: Environmental Health Perspectives (2000)

In this study we report on the finding of monomethylarsonous acid [MMA(III)] in human urine. This newly identified arsenic species is a key intermediate in the metabolic pathway of arsenic biomethylation, which involves stepwise reduction of pentavalent to trivalent arsenic species followed by oxidative addition of a methyl group. Arsenic speciation was carried out using ion-pair chromatographic separation of arsenic compounds with hydride generation atomic fluorescence spectrometry detection. Speciation of the inorganic arsenite [As(III)], inorganic arsenate [As(V)], monomethylarsonic acid [MMA(V)], dimethylarsinic acid [DMA(V)], and MMA(III) in a urine sample was complete in 5 min. Urine samples collected from humans before and after a single oral administration of 300 mg sodium 2,3-dimercapto-1-propane sulfonate (DMPS) were analyzed for arsenic species. MMA(III) was found in 51 out of 123 urine samples collected from 41 people in inner Mongolia 0-6 hr after the administration of DMPS. MMA(III )in urine samples did not arise from the reduction of MMA(V) by DMPS. DMPS probably assisted the release of MMA(III) that was formed in the body. Along with the presence of MMA(III), there was an increase in the relative concentration of MMA(V) and a decrease in DMA(V) in the urine samples collected after the DMPS ingestion.
Neuropsychological Processing Associated With Recovery From Depression After Stereotactic Subcaudate Tractotomy
Authors: T. Dalgleish
Journal: American Journal of Psychiatry (2004)

OBJECTIVE: The authors compared patients who underwent stereotactic subcaudate tractotomy for depression, who were still depressed or recovered from depression, to identify therapeutic mechanisms. METHOD: Ten depressed and eight recovered psychosurgery patients, along with nine never-depressed subjects and nine who had recovered from depression with medication, completed the Iowa Gambling Task, a measure of decision making in the face of feedback. Psychosurgery patients also completed general neuropsychological testing. RESULTS: Recovered psychosurgery patients exhibited insensitivity to negative feedback on the Iowa Gambling Task compared to the other three groups. This difference between the groups remained when general neuropsychological performance was covaried out. CONCLUSIONS: These findings suggest acquired relative insensitivity to negative information as a specific mechanism mediating the antidepressant effect of stereotactic subcaudate tractotomy. Such insensitivity is not secondary to deficits in general neuropsychological functioning and is not a function of recovery from depression per se.
Percutaneous coronary intervention of unprotected left main stenosis in high risk patients: In-hospital, 30-day, and one-year outcome Samin K. Sharma, Annapoorna S. Kini, David Reich, Mazzulah Kamran, Jonathan D. Marmur. The Mount Sinai Medical Center, New York, NY
Journal: Journal of the American College of Cardiology (2001)
Letters to the Editor
Authors: Thomas A. Hinners
Journal: Environmental Health Perspectives (1975)

used with demonstrated accuracy and preci- sion.The purpose of our earlier publication (2) was to make a special plea for the adoption of these procedures so that the data could be more meaningfully compared on an interlaboratory basis for epidemologic studies.We were disappointed that these authors did not fully appreciate this as a useful pro- cedure.This was somewhat surprising since Hinners and Simmons (3) had sagaciously recognized an error in our writing, where the word higher was substituted for the word lower; which was overstated as serious criti- cism, but has been corrected in the literature (4).
DISTRACTION IN THE TREATMENT OF HIP DISEASE.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Annals Graphic Medicine - Dear Doctor II
Authors: K.C. Councilor
Journal: Annals of Internal Medicine (2017)

Web Exclusives5 December 2017Annals Graphic Medicine - Dear Doctor IIFREEK.C. CouncilorK.C. CouncilorFrom Madison, Wisconsin. (K.C.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/G17-0012 SectionsAboutVisual AbstractPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail KC expresses outrage at the insensitive behavior of the emergency room physician. How could things have gone so wrong? Download figure Download PowerPoint Download figure Download PowerPoint Download figure Download PowerPoint Download figure Download PowerPoint Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationAffiliations: From Madison, Wisconsin. (K.C.)Disclosures: The author has disclosed no conflicts of interest. The form can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=G17-0012.Author/Illustrator Information: KC Councilor is a cartoonist, teacher, and doctoral candidate in communication arts (rhetoric, politics, and culture) at the University of Wisconsin-Madison. He draws comics about the experience of being transgender and about being human. You can see more of his work at www.kccouncilor.com.Author Contributions: Conception and design: KC Councilor.Analysis and interpretation of the data: KC Councilor.Drafting of the article: KC Councilor.Final approval of the article: KC Councilor.Collection and assembly of data: KC Councilor.Written and illustrated by KC Councilor. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 5 December 2017Volume 167, Issue 11Page: W53-W57KeywordsBehaviorConflicts of interestDisclosureEmergency department ePublished: 5 December 2017 Issue Published: 5 December 2017 Copyright & PermissionsCopyright © 2017 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
ISRAEL
Journal: JAMA (1960)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal