tbuckley/cabot-search huggingface dataset:
THU0495 IL-22 Drives the Initiation and Augmentation of TH17-Dependent Experimental Arthritis
Authors: D.M. Roeleveld, R.J. Marijnissen, W.B. van den Berg, M.I. Koenders
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Rheumatoid arthritis (RA) is a chronic, inflammatory autoimmune disease that leads to progressive destruction of cartilage and bone. IL-22 and IL-22-producing T helper cells are elevated in RA patients, suggesting a role for this cytokine in the pathogenesis of this disease. Interestingly, IL-22 is a dual cytokine with both proinflammatory and anti-inflammatory properties, and therefore its exact role in RA pathology requires further investigation. <h3>Objectives</h3> The aim of this study was to explore the role of IL-22 in the initiation and severity of a spontaneous model of experimental arthritis by using gene knockout mice and neutralizing antibodies for IL-22. In addition, we aimed to determine the influence of IL-22 on T cell subsets and cytokines in our mouse model. <h3>Methods</h3> IL-1Ra-deficient mice develop spontaneous arthritis due to excess IL-1 signaling, and we previously demonstrated the importance of IL-17 and Th17 cells in this model (Koenders, Arthritis Rheum 2008). To investigate the role of IL-22 in this Th17-dependent arthritis model, we compared IL-1Ra<sup>–/–</sup> x IL-22<sup>+/+</sup> mice to mice lacking both IL-1Ra and IL-22. Paw joint swelling was scored weekly, and mice were sacrificed at the age of fifteen weeks. In addition, IL-1Ra-deficient mice were treated for 4 weeks with anti-IL-22 neutralizing antibodies administered after onset of arthritis to inhibit disease progression. <h3>Results</h3> IL-1Ra<sup>–/–</sup> mice also deficient for IL-22 showed reduced incidence of arthritis, as well as reduced joint swelling and bone erosion. In line with the suppressed arthritis, the proinflammatory Th1 and Th17 cell numbers were decreased in spleens of mice lacking IL-22. Interestingly, also the levels of Treg cells were suppressed in the double knockout mice. Furthermore, IL-1Ra-deficient mice treated with anti-IL-22 antibodies after the clinical onset of arthritis showed reduced progression on inflammation and significant inhibition on bone erosion. This indicates that not only the onset but also the progression of arthritis is dependent on IL-22. Interestingly, reduced IL-17 serum levels were found after IL-22 blocking, suggesting a not previously observed feedback loop of IL-22 on Th17 cells. <h3>Conclusions</h3> These findings suggest that the Th17 cytokine IL-22 plays an important role both in initiation and augmentation of experimental arthritis, and might therefore be an interesting new target in RA treatment. <h3>Disclosure of Interest</h3> : None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.3528
Aspirin effects on mortality and morbidity in patients with diabetes mellitus. Early Treatment Diabetic Retinopathy Study report 14. ETDRS Investigators
Journal: JAMA (1992)

<h3>Objectives.</h3> —This report presents information on the effects of aspirin on mortality, the occurrence of cardiovascular events, and the incidence of kidney disease in the patients enrolled in the Early Treatment Diabetic Retinopathy Study (ETDRS). <h3>Study Design.</h3> —This multicenter, randomized clinical trial of aspirin vs placebo was sponsored by the National Eye Institute. <h3>Patients.</h3> —Patients (N=3711) were enrolled in 22 clinical centers between April 1980 and July 1985. Men and women between the ages of 18 and 70 years with a clinical diagnosis of diabetes mellitus were eligible. Approximately 30% of all patients were considered to have type I diabetes mellitus, 31% type II, and in 39% type I or II could not be determined definitely. <h3>Intervention.</h3> —Patients were randomly assigned to aspirin or placebo (two 325-mg tablets once per day). <h3>Main Outcome Measures.</h3> —Mortality from all causes was specified as the primary outcome measure for assessing the systemic effects of aspirin. Other outcome variables included cause-specific mortality and cardiovascular events. <h3>Results.</h3> —The estimate of relative risk for total mortality for aspirin-treated patients compared with placebo-treated patients for the entire study period was 0.91 (99% confidence interval, 0.75 to 1.11). Larger differences were noted for the occurrence of fatal and nonfatal myocardial infarction; the estimate of relative risk was 0.83 for the entire follow-up period (99% confidence interval, 0.66 to 1.04). <h3>Conclusions.</h3> —The effects of aspirin on any of the cardiovascular events considered in the ETDRS were not substantially different from the effects observed in other studies that included mainly nondiabetic persons. Furthermore, there was no evidence of harmful effects of aspirin. Aspirin has been recommended previously for persons at risk for cardiovascular disease. The ETDRS results support application of this recommendation to those persons with diabetes at increased risk of cardiovascular disease. (<i>JAMA</i>. 1992;268:1292-1300)
SportsMedUpdate
Authors: Martin P Schwellnus
Journal: British Journal of Sports Medicine (2009)

▸ Bedair HS, Karthikeyan T, Quintero A, et al . Angiotensin II receptor blockade administered after injury improves muscle regeneration and decreases fibrosis in normal skeletal muscle. Am J Sports Med 2008; 36 :1548–54. ### Background: Inhibition of fibrosis and improving regeneration after injury in skeletal muscle may be achieved by transforming growth factor β1 antagonists such as angiotensin receptor blockers ### Research question/s: In an animal model of a laceration injury of the skeletal muscle, does an angiotensin receptor blocker decrease fibrosis and improve muscle regeneration? ### Methodology: Subjects: 40 mice Experimental procedure: All the animals underwent bilateral gastrocnemius lacerations and were then assigned randomly to three treatment groups: a control group (CON — tap water), a low-dose angiotensin receptor blocker group (losartan, 0.05 mg/ml, dissolved in tap water and administered enterally) (ARBld), or a high-dose angiotensin receptor blocker group (0.5 mg/ml) (ARBhd). Animals were killed 3 or 5 weeks after injury, and the lacerated muscles were examined histologically for muscle regeneration and fibrosis Measures of outcome: Muscle regeneration (number of regenerating myofibres within a high power field), area of fibrosis (%) at 3 weeks and 5 weeks ### Main finding/s: ### Conclusion/s:
Structural variants of prolactin: occurrence and physiological significance
Authors: Y. N. Sinha
Journal: Endocrine Reviews (1995)

Journal Article Structural Variants of Prolactin: Occurrence and Physiological Significance Get access Y. N. Sinha Y. N. Sinha 1Department of Biochemistry and Clinical Physiology, Whittier Institute for Diabetes and Endocrinology La Jolla, California 92037 *Address correspondence to: Y. N. Sinha, Ph.D., 8385 Aries Road, San Diego, California 92126. Search for other works by this author on: Oxford Academic Google Scholar Endocrine Reviews, Volume 16, Issue 3, 1 June 1995, Pages 354–369, https://doi.org/10.1210/edrv-16-3-354 Published: 01 June 1995
Early Surgical Treatment of Valvular Endocarditis
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reprieve
Authors: Judith Skillman
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reimbursement, beneficence, and advance directives
Authors: Kenneth Grant
Journal: JAMA (1991)

<h3>To the Editor.</h3> —The thoughtful discussion of the Patient Self-Determination Act of 1990 by La Puma et al<sup>1</sup>and White and Fletcher<sup>2</sup>is timely because of the recent December 1,1991, deadline for the act's implementation by hospitals, nursing homes, and hospices. However, there is a danger that health care professionals forced by legislatively imposed time constraints merely to comply with the act, may then, in their zeal, mistakenly become salesmen of advance directives to acutely ill hospitalized patients. Both sets of<i>JAMA</i>authors agree that the acute care setting is not optimal for discussion of advance directives, and then inexplicably go on to discuss additional ways to involve the attending physician and primary nurses in such discussions. It seems that the authors agree that it is not just legally expedient, but ethically correct to make the treating physician the salesman of advance directives to patients who, the authors
YELLOW FEVER.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Transplantation, Baltimore
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Lumleian Lectures on the Pathology of Intra-Uterine Death
Authors: W. O. Priestley
Journal: BMJ (1887)

case in which aeute dilatation with bemonptysis had occurred fromr over-exertion; a mitral aystolic mumur remalned; tbe artery was noi large.li Lthe e-e from which the second was taken there were breath- lessness, difficulty of lying down, and enlargement of the lirer, all of which were relieved by treatment.The patient whose pulse is represnted by the third, was liable to stagger and even fall, on ris- ing from a semi-recumbent position, with momentary loss of conscious- ness, anA.nin Flijet exprtiin, he wonld suddenly lose all pn'wer.The artery ws alw&ys lulil betwtee the beats, uotwithstaiiding tLe appear- ance of the trace.He improved under treatment, could walk eight miles, was more cheerful, and could lie on his side; the ptils,-oave :~~~~~~~~~~~t he second trace.Later, over-exertion aggravated the dilatation, and thrombosis of the left middle cerebral artery occurred, the case endincg fatally.
Effectiveness of nicotine patches in relation to genotype in women versus men: randomised controlled trial
Authors: Patricia Yudkin, Marcus Munafò, Kate Hey, Sarah Roberts, Sarah Welch, Elaine Johnstone, Michael Murphy, Siân Griffiths, Robert Walton
Journal: BMJ (2004)

as smoking and exposure to secondhand smoke outside the home were more prevalent in New Zealand in the early 1980s.This may explain the apparently stronger association between household exposure and mortality in the 1996-9 cohort compared with the 1981-4 cohort.The results from this study add to the weight of evidence of harm caused by passive smoking and support steps to reduce exposure to other people's smoke-in the home and in other settings.We thank Jackie Fawcett and June Atkinson for technical help with data extraction and analysis.
Omission of Name and Affiliation of a Source in: Traumatic Brain Injury a Growing Problem Among Troops Serving in Today's Wars
Authors: Rachel Nardin, Leah Zallman, Cassie Frank, Benjamin Day, Ma Boyd
Journal: JAMA (2011)

ing discourages students from seeking both MHT and SAT. 5 The study may have underestimated the MHT available to medical students, who may access care through student health centers or have more generous coverage through their schools or parents.Coverage offered by US medical schools is unlikely to be worse than that available to the nonstudent population.Most private insurance plans have annual limits; for example, one study found that 90% of plans limit outpatient MHT and 93% limit outpatient SAT. 6This parity is not reassuring given the importance to the medical profession and patients of aggressively treating these disorders.
Abstract 857: Identification and functional analysis of FGFR2 binding proteins in diffuse-type gastric carcinoma
Authors: Takuya Shirakihara, Ryuichi Sakai
Journal: Cancer Research (2019)

Abstract Diffuse-type gastric carcinoma (DGC) is highly invasive subtype of gastric adenocarcinomas and frequently exhibit scattered peritoneal metastasis. Previous studies have shown that genes of receptor tyrosine kinases (RTKs) such as FGFR2 or Met are amplified in DGC cell lines with high frequency. Hence, these cells exhibit oncogene addiction to sustained activity of these RTKs for maintenance of malignant phenotype. In order to gain novel insight in the downstream signaling pathway of DGC-specific RTKs, phosphoproteomic analysis was performed. Phosphotyrosine-containing proteins associated with RTKs were purified through two sequential rounds of immunoprecipitation from lysates of RTK-amplified DGC cell lines. Here we will show the initial functional data of transferrin receptor (TFRC), one of the identified proteins by MS analysis. In the DCG cells with FGFR2 amplification, TFRC proteins were found to bind FGFR2 and were phosphorylated at Tyr20. Moreover, shRNA knockdown of TFRC as well as inhibitor of FGFR2 revealed effective impairment in cell proliferation. These results suggest that TFRC has essential roles in malignancy of FGFR2-dependent DGC. Citation Format: Takuya Shirakihara, Ryuichi Sakai. Identification and functional analysis of FGFR2 binding proteins in diffuse-type gastric carcinoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 857.
Preservation of normal lung regions in the adult respiratory distress syndrome. Analysis by computed tomography
Authors: R. J. Maunder
Journal: JAMA (1986)

In this report, we challenge the commonly held assumption that the adult respiratory distress syndrome (ARDS) is a homogeneous process associated with generalized and relatively uniform damage to the alveolar capillary membrane. We studied 13 patients with ARDS, comparing the pulmonary parenchymal changes seen by standard bedside chest roentgenograms with those seen by computed tomography of the chest. Three patients demonstrated generalized lung involvement by both radiologic techniques. In another eight patients, despite the appearance of generalized involvement on the standard chest x-ray film, the computed tomographic scans showed patchy infiltrates interspersed with areas of normal-appearing lung. Two patients showed patchy involvement by both techniques. The fact that ARDS spares some regions of lung parenchyma is useful knowledge in understanding the gas-exchange abnormalities of ARDS, the variable responsiveness to positive end-expiratory pressure, and the occurrence of oxygen toxicity. The problem of regional inhomogeneity should also be kept in mind when interpreting lung biopsy specimens or bronchoalveolar lavage fluid in patients with ARDS. (<i>JAMA</i>1986;255:2463-2465)
Chest Pain as an Unusual First Symptom in Patients with Systemic Amyloidosis
Journal: Annals of Internal Medicine (1999)

Summaries for Patients7 December 1999Chest Pain as an Unusual First Symptom in Patients with Systemic AmyloidosisSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-131-11-199912070-00029 SectionsAboutFull Text ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Systemic amyloidosis is a rare disease caused by the buildup of an abnormal protein substance called amyloid in body tissues. Amyloidosis can affect many organs of the body, but involvement of the heart and blood vessels is the most common cause of illness and death in patients with this disease. In patients whose heart and blood vessels are affected by amyloidosis, shortness of breath, leg swelling, or abnormal heart rhythms are usually the first signs that they have this disease. Angina pectoris (chest pain) has not been thought ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Systemic Amyloidosis Presenting with Angina Pectoris.” It is in the 7 December 1999 issue of Annals of Internal Medicine (volume 131, pages 838-841). The authors are J. Al Suwaidi, J.L. Velianou, M.A. Gertz, R.O. Cannon III, S.T. Higano, D.R. Holmes Jr., and A. Lerman.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine. Previousarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoSystemic Amyloidosis Presenting with Angina Pectoris Jassim Al Suwaidi , James L. Velianou , Morie A. Gertz , Richard O. Cannon III , Stuart T. Higano , David R. Holmes Jr. , and Amir Lerman Metrics Cited byHeart involvement in AL-amyloidosis. Current state of the issue 7 December 1999Volume 131, Issue 11Page: 838KeywordsAmyloidosisAnginaBiopsyBlood vesselsCardiovascular therapyCatheterizationHeartHeart diseasesIschemiaMyocardial infarction ePublished: 15 August 2000 Issue Published: 7 December 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.Loading ...
The Pullman System of Epuration of Sewerage.
Journal: JAMA (1884)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal