Bone Marrow Transplantation with Intensive Combination Chemotherapy/Radiation Therapy (SCARI) in Acute Leukemia
Journal: Annals of Internal Medicine (1977)

Article1 February 1977Bone Marrow Transplantation with Intensive Combination Chemotherapy/Radiation Therapy (SCARI) in Acute LeukemiaAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-86-2-155 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail AbstractAbstractFifteen patients with acute leukemia resistant to standard chemotherapy were treated by bone marrow transplantation from HLA-matched siblings after conditioning with a new combination chemotherapy/radiation therapy regimen—SCARI. SCARI consists of 5 days of high-dose cytosine arabinoside and 6-thioguanine followed by 3 days of daunorubicin. After a rest period, cyclophosphamide and total-body irradiation are given sequentially. This regimen had acceptable morbidity. Median survival was 169 days. Overall survival and disease-free survival was 27% at over 11 months. Relapse rate was 13% of the entire group and 30% by actuarial projection. Relapses were late and initially extramedullary. Deaths from causes other than leukemia occurred early secondary to fungal infection and late secondary to interstitial pneumonia (frequently cytomegalovirus). Graft-versus-host disease and graft rejection were not causes of mortality. In these patients conditioned with SCARI, leukemic recurrences were infrequent but infectious complications were a major hazard.References1. GUNZBAIKIE FA: Leukemia, 3rd ed. New York, Grune & Stratton, 1974 Google Scholar2. THOMASSTORBCLIFT ERR: Bone-marrow transplantation. N Engl J Med 292:832-843, 895-902, 1975 CrossrefMedlineGoogle Scholar3. THOMASBUCHNERCHEEVER ECM: Marrow transplants for leukemia and aplastic anemia. Transplant Proc, 1976, in press Google Scholar4. FEIGOPELZWINTER SGH: Successful bone marrow transplantation against mixed lymphocyte culture barrier. Blood 48:385-391, 1976 CrossrefMedlineGoogle Scholar5. 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To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Gregory Sarna, Steven Feig, Gerhard Opelz, Lowell Young, F.A.C.P., Edward Langdon, Guy Juillard, Faramarz Naiem, Robert Sparkes, David Golde, Mary Territo, Charles M. Haskell, George Smith, Fawzi Fawzi, Peter Falk, John Fahey, Martin Cline, F.A.C.P., and Robert Peter Gale.▸From the Departments of Medicine, Pediatrics, Microbiology and Immunology (Human Immunobiology Group), Radiation Therapy, Pathology, and Psychiatry; University of California, Los Angeles, The Center for the Health Sciences; Los Angeles, California. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAUTOLOGOUS BONE MARROW TRANSPLANTATION IN ACUTE LEUKEMIATrying to Overcome Residual Disease After Bone Marrow Transplantation for Hematologic MalignanciesEpidemiology of digestive tract mycoses in immunocompromised patients ? 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WINSTON, M.D., GERALD SCHIFFMAN, Ph.D., DAISY C. WANG, STEVEN A. FEIG, M.D., CHENG-HSIEN LIN, EUGENE L. MARSO, WINSTON G. HO, M.D., LOWELL S. YOUNG, M.D., ROBERT P. GALE, M.D., Ph.D.Chronic graft versus host disease: A syndrome of disordered immunityBone Marrow Transplantation for Aplastic Anemia: Conditioning with Cyclophosphamide plus Low-Dose Total-Body IrradiationTumour immunity and immunotherapyMarrow transplantation for acute leukemiaBone marrow transplantation for acute leukaemiaRelapse Following Marrow Transplantation for Acute LeukemiaThe Role of Cyclophosphamide and Total-body Irradiation in Marrow Transplantation for Severe Aplastic AnemiaBone Marrow TransplantationMarrow Transplantation in the Treatment of Acute LeukemiaBONE-MARROW TRANSPLANTATION IN ACUTE LEUKÆMIAAutologous Bone Marrow Repopulation following High Dose Cyclophosphamide and Allogeneic Marrow Transplantation in Aplastic Anaemia 1 February 1977Volume 86, Issue 2Page: 155-161KeywordsBone marrow transplantationCytosineDisease free survivalImmunologyInterstitial lung diseasesMicrobiologyMorbidityMortalityPediatricsRadiation therapy ePublished: 1 December 2008 Issue Published: 1 February 1977 PDF downloadLoading ...