tbuckley/cabot-search huggingface dataset:
Mimeae Septicemia
Authors: Robert L. Richardson
Journal: JAMA (1969)

<h3>To the Editor:—</h3> Mimeae infections occur only under unusual circumstances and only recently<sup>1-7</sup>have been recognized as clinically significant. This report presents four cases believed to represent Mimeae infections that were successfully treated. <h3>Report of Cases:—Case 1.—</h3> A 7-year-old white girl with severe congestive heart failure and septicemia was found to have initial cultures of the blood positive for<i>Staphylococcus aureus</i>which was sensitive to penicillin and chloramphenicol. A satisfactory initial response was obtained and cultures of the blood were negative during the second and third weeks. During the fourth week fever returned and failure became progressively worse. A grade 3 systolic murmur became audible. Blood cultures on the 27th hospital day revealed a heavy growth of<i>Herellea</i>and it was the consensus that a diagnosis of endocarditis due to<i>Herellea</i>was justified. Kanamycin was given immediately and marked clinical improvement was noted within 48 hours. Subsequent
A Novel Bone Substitute with High Bioactivity, Strength, and Porosity for Repairing Large and Load‐Bearing Bone Defects
Authors: Jiao Jiao Li, Colin R. Dunstan, Ali Entezari, Qing Li, Roland Steck, Siamak Saifzadeh, Ameneh Sadeghpour, John R. Field, Austin Akey, Martin Vielreicher, Oliver Friedrich, Seyed‐Iman Roohani‐Esfahani, Hala Zreiqat
Journal: Advanced Healthcare Materials (2019)

Adv. Healthcare Mater. 2019, 8, 1801298 In the initially published version of this article, the author list and affiliations were incorrect. The correct author list is as follows: Jiao Jiao Li, Colin R. Dunstan, Ali Entezari, Qing Li, Roland Steck, Siamak Saifzadeh, Ameneh Sadeghpour, John R. Field, Austin Akey, David C. Bell, Martin Vielreicher, Oliver Friedrich, Seyed-Iman Roohani-Esfahani, and Hala Zreiqat* The correct affiliation for D.C.B. is as follows: Dr. A. Akey, Prof. D. C. Bell Center for Nanoscale Systems Harvard University Cambridge, MA 02138, USA
Confidentiality of Occupational Health Records
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Arsenic Methylation Patterns before and after Changing from High to Lower Concentrations of Arsenic in Drinking Water
Authors: Claudia Hopenhayn-Rich, Mary Lou Biggs, David A. Kalman, Lee E. Moore, Allan H. Smith
Journal: Environmental Health Perspectives (1996)

Inorganic arsenic (In-As), an occupational and environmental human carcinogen, undergoes biomethylation to monomethylarsonate (MMA) and dimethylarsinate (DMA). It has been proposed that saturation of methylation capacity at high exposure levels may lead to a threshold for the carcinogenicity of In-As. The relative distribution of urinary In-As, MMA, and DMA is used as a measure of human methylation capacity. The most common pathway for elevated environmental exposure to In-As worldwide is through drinking water. We conducted a biomarker study in northern Chile of a population chronically exposed to water naturally contaminated with high arsenic content (600 micrograms/l). In this paper we present the results of a prospective follow-up of 73 exposed individuals, who were provided with water of lower arsenic content (45 micrograms/l) for 2 months. The proportions of In-As, MMA, and DMA in urine were compared before and after intervention, and the effect of other factors on the distribution of arsenic metabolites was also analyzed. The findings of this study indicate that the decrease in arsenic exposure was associated with a small decrease in the percent In-As in urine (from 17.8% to 14.6%) and in the MMA/DMA ratio (from 0.23 to 0.18). Other factors such as smoking, gender, age, years of residence, and ethnicity were associated mainly with changes in the MMA/DMA ratio, with smoking having the strongest effect. Nevertheless, the factors investigated accounted for only about 20% of the large interindividual variability observed. Genetic polymorphisms in As-methylating enzymes and other co-factors are likely to contribute to some of the unexplained variation. The changes observed in the percent In-As and in the MMA/DMA ratio do not support an exposure-based threshold for arsenic methylation in humans.
Film Reviews
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Autoimmune cholangiopathy: Part of the spectrum of autoimmune chronic active hepatitis
Authors: Z Ben-Ari
Journal: Hepatology (1993)

We describe four patients with features overlapping those of primary biliary cirrhosis and autoimmune chronic active hepatitis. Three were female and one was male; only one was symptomatic. Serum biochemical study showed increases in alkaline phosphatase and α-glutamyltranspeptidase levels. Markers of hepatitis B and C viruses were absent. In all four patients, serum mitochondrial antibodies could not be detected on immunofluorescence study and serum M2 antibodies were absent. All four patients had high titers of serum antinuclear antibody of diffuse type. Serum actin antibodies were detected in all four patients. Liver biopsy specimens showed histological features of primary biliary cirrhosis, with marked cellular infiltration of the portal areas and bile duct damage. Intralobular inflammation and piecemeal necrosis were mild. Three patients were treated with prednisolone and showed rapid clinical and biochemical remission. Serial liver biopsy specimens showed reduced inflammation, but bile duct lesions persisted. These patients probably form a subgroup of autoimmune chronic active type 1 with predominant bile duct damage. The subgroup might be termed autoimmune cholangiopathy. (HEPATOLOGY 1993;18:10–15).
The recognition of hepatic metastases through radioisotope color scanning
Authors: S. Baum
Journal: JAMA (1966)

With the color technique for radioisotope scanning, gold Au 198 scans of the liver were correlated with the pathological findings in 116 patients. Scans were interpreted as being positive for space-occupying lesions in 46 patients, of whom 41 were proved to have metastases. In 70 patients, the scan was interpreted as showing no evidence of space-occupying lesions. This diagnosis was borne out pathologically in all but one patient. Since each color represents a given percentage of radioactivity, it is possible to interpret the color scan in a semiquantitative manner. Space-occupying lesions of the liver, indicated by areas of reduced radioactivity, can be easily identified on the scan. It is suggested that the close correlation between the scan and pathological findings is due to more objective evaluation of semiquantitative data when the color technique is used.
Protection of left ventricular function with recombinant soluble P-selectin glycoprotein ligand-Ig in the canine coronary balloon occlusion model Kai Wang, Zhongmin Zhou, Xiaorong Zhou, Khaldoun Tarakji, Jian Xin Qin, Marta Sitges, Marta Sitges, Takahiro Shiota, Eric Topol, A. Michael Lincoff. The Cleveland Clinic Foundation, Cleveland, OH
Journal: Journal of the American College of Cardiology (2001)
Role of Fat Replacers in Diabetes Medical Nutrition Therapy: American Diabetes Association
Journal: Diabetes Care (1996)

Foods with fat replacers have the potential to help people with diabetes reduce total and saturated fat intake and may therefore, in time, reduce the increased prevalence of dyslipidemia in type II diabetes. However, for these foods to have any potential benefit to people with diabetes, people with diabetes must learn to use them appropriately. People with diabetes should receive self-management training on how to identify ingredients that are fat replacers on labels, how to use the food label to determine serving sizes, and how to incorporate these foods into their food/meal plan, along with the selection of a wide variety of nutritious foods. Health professionals and people with diabetes need to keep current with the ever-changing market-place, available food products, and growing body of scientific literature. Additional research is needed to assess the impact of the use of fat replacers on the macronutrient content of the diet, metabolic parameters related to diabetes, and potential health and nutrition benefits for the person with diabetes.
How costly is brain cancer? Healthcare services use and costs from across the US
Authors: L. Kutikova, L. Bowman, S. Chang, S. Long
Journal: Journal of Clinical Oncology (2004)

1559 Background: Our research goal was to provide timely estimates of economic burden of brain cancer to the US healthcare system for patients (pts) across the US, and identify primary cost drivers. Methods: Retrospective cohort analysis of direct costs and healthcare services use in brain cancer pts and controls was conducted using MarketScan™ US employers' claims databases of over 3 million individuals. Cases were pts newly diagnosed with brain cancer in 1999–2000. Controls were individuals without cancer diagnosis and matched 3:1 with cases (97.5% match) on age, gender, healthcare coverage, region (e.g., West), and follow-up length. Utilization of healthcare services and costs were standardized to monthly means. Results: The study consisted of 652 cases and 1,959 controls. 40% of cases had late stage disease. Median age was 56 years for cases and 55 years for controls. Mean follow-up was 10.9 months for both groups. Mean monthly rates of hospitalizations, length of stay, emergency room visits, office visits, outpt radiology and laboratory procedures, and pharmacy-dispensed prescription drugs were all higher for cases than controls (p<0.0001). Cases had a 20 times higher monthly rate of hospitalization than controls (0.2 vs. 0.01). Mean monthly rate of office visits was 5.1 for cases vs. 0.8 for controls. Cases had more mean monthly prescription drugs than controls (3.4 vs. 1.1). Similarly, mean monthly total, inpt and outpt costs of cases were several times higher compared to controls (p<0.0001). Mean monthly total costs were $7,081 for cases and $237 for controls, hospitalizations accounted for $4,502 of the mean monthly total costs for cases and $58 for controls. Mean monthly costs associated with office visits were $1,501 for cases vs. $97 for controls. Conclusions: Pts with brain cancer accrued costs that were 23 times higher than demographically similar population without cancer. Office visits were the most frequent service; inpt costs were drivers of total costs. Despite its small incidence, the burden of brain cancer to the healthcare system is substantial and suggests a need for increased prevention or new therapies to impact resource use and healthcare costs. No significant financial relationships to disclose.
EFFECT OF UNDERNOURISHMENT ON MAMMALIAN OVARY AND THE SEXUAL CYCLE
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Need for awareness and monitoring of ocular toxicities (OT) due to weekly docetaxel administration: experience during a trial of neoadjuvant docetaxel (D) and mitoxantrone (M) for patients with high-risk prostate cancer (PC)
Authors: C. S. Higano, T. M. Beer, M. Garzotto, C. W. Ryan, M. Pitzel, C. R. Works, S. P. Hall
Journal: Journal of Clinical Oncology (2004)

4577 Background: Epiphora (E), excessive tearing (ET) due to insufficient drainage, is toxicity unique to 5FU or D. It is more common with q wk versus q 3 wk D (Esmaeli, Ophthalmology 2002). D is secreted in tears and causes inflammation and canalicular stenosis resulting in E, which can cause significant problems with reading, driving, and other activities as well as present the false impression of crying. While it has been reported mainly in pts with breast cancer, E has also been seen in other tumors treated with weekly D. Our preliminary experience in PC pts is presented. Methods: Pts with high-risk PC were treated with neoadjuvant D 35 mg/M2 and M 4 mg/M2 q wk x 3, with 1 wk off, for a total of 12 doses prior to radical prostatectomy. Pts who developed ET were instructed to use artificial tears; if symptoms (sx) did not improve, 1% prednisolone acetate eye drops were prescribed on the day before, the day of, and the day after chemotherapy. Results: Of 41 pts on protocol, 21 had ocular sx including blurry vision (1), eye irritation (1), ET (15), dry eyes (2–1 had ET later), photophobia (1), ingrown eyelashes (1), or infection of the upper eyelid (1). ET occurred at a median of 7.5 weeks (range 1–17) after starting chemotherapy. None of 6 pts treated with steroid eye drops improved and 1 with pre-existing glaucoma experienced an increase in intra-ocular pressure (IOP) requiring addition of a beta-blocker eye drop. In five pts who saw an ophthalmologist, ET was due to canalicular stenosis (2), ingrown eyelashes (1), “floppy eyelid syndrome”(1), normal (1). Conclusions: Weekly D and M can cause significant OT. Given these findings, baseline ophthalmologic evaluation and monthly follow-up are recommended. As weekly D administration is widespread and the impact of OT on quality of life can be significant, prophylactic use of artificial tears and/or steroid drops, and early intervention with silicone intubation of the canaliculi should be studied. Better documentation of the range and grading of OT due to D is needed. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Aventis
Several choices available for repair of ligamental tears in the knee
Authors: V. S. Cowart
Journal: JAMA (1990)

ONCE A TEAR is diagnosed, some surgeons still open the knee for repair, but the move is toward arthroscopic surgery, which has dramatically reduced the morbidity associated with knee surgery. Most often, it appears, the orthopedic surgeon simply mends the tear in the ligament. But when it has failed completely, reconstruction or replacement of the ligament will be necessary. The choices for repair include autografts, allografts, and prosthetic ligaments. Some surgeons have used the patellar tendon as a substitute for the anterior cruciate ligament. Other graft choices include semitendinosus, gracilis, iliotibial band, fascia lata, and retinaculum. Frank R. Noyes, MD, Cincinnati (Ohio) Sportsmedicine Center, prefers to use allografts of the anterior cruciate ligament. But he cautions they should be irradiated to guard against transmission of human immunodeficiency virus. The key to successful surgery, Noyes says, is the placement of the graft at the ideal isometric point. "The most common mistake
Respiratory and Cardiac Arrest After Intravenous Administration of Kanamycin with Reversal of Toxic Effects by Neostigmine
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Multi-institutional validation of the predictive value of Ki-67 in patients with high-grade urothelial carcinoma of the upper urinary tract.
Authors: Laura-Maria Krabbe, Aditya Bagrodia, Ahmed Haddad, Payal Kapur, Dina Khalil, Linda S. Hynan, Christopher G. Wood, Jose A. Karam, Alon Z. Weizer, Jay D. Raman, Mesut Remzi, Nathalie Rioux-Leclercq, Andrea Haitel, Marco Roscigno, Christian Bolenz, Karim Bensalah, Arthur I. Sagalowsky, Shahrokh F. Shariat, Yair Lotan, Vitaly Margulis
Journal: Journal of Clinical Oncology (2015)

4569 Background: To validate the independent predictive value of Ki-67 in patients with high-grade upper tract urothelial carcinoma (UTUC). Methods: 475 patients from the international UTUC collaboration who underwent extirpative surgery for high-grade UTUC were included in this study. Immunohistochemical staining for Ki-67 was performed on tissue microarray (TMA) formed from this patient cohort. Ki-67 expression was assessed in a semi-quantitative fashion and considered overexpressed at a cut-off of 20%. Multivariate analyses (MVA) were performed to assess independent predictors of oncological outcomes and Harrell’s C indices (HCI) were calculated for predictive models. Results: Median age of the cohort was 69.7 years and 55.2% of patients were male. Ki-67 was overexpressed in 25.9% of patients. Ki-67 overexpression was significantly associated with ureteral tumor location, higher pT-stage, lymphovascular invasion, sessile tumor architecture, tumor necrosis, concomitant carcinoma in situ (CIS), and regional lymph node metastases. In Kaplan-Meier analyses, overexpressed Ki-67 was associated with worse recurrence-free (RFS) (HR 12.6, p < 0.001) and cancer-specific survival (CSS) (HR 15.8, p < 0.001). In MVA, Ki-67 was an independent predictor of RFS (HR 1.6, 95% CI 1.07-2.30, p = 0.021) and CSS (HR 1.9, 95% CI 1.29-2.90, p = 0.001). Ki-67 improved HCI from 0.66 to 0.70 (p < 0.0001) for both RFS and CSS in our preoperative model, and from 0.81 to 0.82 (p = 0.0018) for RFS and 0.81 to 0.83 (p = 0.005) for CSS in our post-operative model. Conclusions: Ki-67 was validated as an independent prognostic predictor of RFS and CSS in patients treated with extirpative surgery for high-grade UTUC in a large, multi-institutional cohort.
Correction: General medical disorders and the eye
Journal: BMJ (1988)

with summary bias equal to -0-0003.Sample variances ranged between 0-000 and 0-023 with a summary variance of 0 006.The summary estimate of mean square error was 0 007.Thus, the estimated bias, variance, and mean square error of the power estimates were small.All users correctly determined power within 5% of the true power in eight or more of the 11 examples, with a 90% overall rate of correct determina- tions.Eight of the 17 participants correctly determined power for all examples.After the evaluation the graphs were refined using computer plotting with improved scaling of the abscissa, which should enhance the accuracy of the aid.
A CANADIAN ANANIAS.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal