tbuckley/cabot-search huggingface dataset:
Suspected Testicular Torsion: A Survey of Clinical Practice in North West England
Authors: I Pearce, S Islam, I G Mcintyre, K J O'Flynn
Journal: Journal of the Royal Society of Medicine (2002)

Several aspects of the management of suspected testicular torsion are controversial. A questionnaire was mailed to all 33 consultant urologists in the North West region of England to elicit their policies for routine clinical management. 29 of 33 questionnaires were returned (2 incomplete). As regards radiological investigation, 4 consultants always request ultrasound examination; the others do not favour routine imaging. When the diagnosis of testicular torsion is confirmed at operation, all consultants would perform bilateral testicular fixation, although with considerable variations in technique; most use Vicryl sutures (66%) and three-point fixation (57%). One-third would do an ipsilateral orchidopexy if there was no clear evidence of testicular torsion at operation. The variation revealed by this survey prompted an attempt to formulate a protocol for management. A review of the published work indicates that, in cases of proven testicular torsion, treatment should include bilateral fixation with delayed-absorption or non-absorbable sutures; fixation should be at three points. When torsion is not found at operation, there is no evidence of benefit from orchidopexy.
HERPES GESTATIONIS.
Authors: BRIAN RUSSELL, N. A. THORNE
Journal: British Journal of Dermatology (1957)

Journal Article HERPES GESTATIONIS. Get access BRIAN RUSSELL, M.D.(Lond.), F.R.C.P., D.P.H., BRIAN RUSSELL, M.D.(Lond.), F.R.C.P., D.P.H. Physician in Charge of the Skin Department, The London Hospital Search for other works by this author on: Oxford Academic Google Scholar N. A. THORNE, M.D.(Lond.), M.R.C.P. N. A. THORNE, M.D.(Lond.), M.R.C.P. Physician in Charge of the Skin Department, Prince of Wales's General Hospital, Tottenham Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 69, Issue 10, 1 October 1957, Pages 339–357, https://doi.org/10.1111/j.1365-2133.1957.tb13770.x Published: 01 October 1957
Immunoassay of Insulin with Insulin Antibody Precipitate-C. N. Hales and P. J. Randle
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Indirect Radiotherapy
Authors: W. Vignal
Journal: BMJ (1942)

BRITISHsupport to this notion.In Case 5 one cannot believe that the bees should have missed the veins a dozen times a year for 20 years and in the ensuing 9 months punctured them 11 times in succession.And in Cases 1, 2, and 3 it is hard to imagine that not one out of so many hundreds of stings should have struck a vein in the dermis.In fact, this theory of venepuncture is superfluous.A better explanation of such sudden deaths can be given in terms of idiosyncrasy, hypersensitiveness, allergy, or anaphylaxis.If the signs and symptoms observed in severe or fatal cases of bee-stings are compared with those recorded (Bray, 1934; Lamson, 1924) in severe or fatal cases of Kerum disease, as in the accompanying Table, the two -are seen to be nearly identical, and death in each case can properly be set down to anaphylactic shock. SummaryThe frequency of bee-stings in Kenya Colony is noted.Three cases of multiple bee-stings with recovery and 2 fatal cases are recorded.The suggestion that fatal cases occur when the sting penetrates a vein is discredited.It is argued that death in fatal cases of bee-stings is due to anaphylactic shock, as it is in fatal cases of serum disease.
Correction: Decontamination of instruments and control of cross infection in general practice
Journal: BMJ (1990)

determine the cause of limited mobility: osteoarthritis of hips or knees, chiropody problems, etc.In contrast, disease oriented or problem oriented screening would require a long checklist of problems to be gone through-a much more time consuming method.It is also inefficient as it will almost certainly create a long list of problems -that is, apparent unmet needs - when in reality many of these problems are of minimal functional importance.In terms of chiropody it is less important to determine the number of older people with corns and bunions than those who are experiencing difficulties with footwear or walking because of chiropody problems.Criteria forfunctional assessment ofpatients aged over 75 Mobility Senses Continence General function Gait Problems with conversation or television Frequency Cooking Negotiating stairs Ear wax Dysuria Diet Rising from chair Use of hearing aid Stress incontinence Shopping Transferring Able to read newspapers Prostatic symptoms Dressing Balance Recognises faces across the room Pattern of bowel function Bathing Use of aids State of glasses Recent changes Toileting Laxative use Faecal staining
Recruitment of Phagocytizing Cells into the Respiratory Tract as a Response to the Cytotoxic Action of Deposited Particles
Authors: Boris A. Katsnelson, Larissa I. Privalova
Journal: Environmental Health Perspectives (1984)

Recruitment of phagocytizing cells into the lower respiratory tract plays a very important role in the pulmonary dust clearance, depending both on the number of particles deposited therein and on their aggressiveness. The higher cytotoxicity of the particles, the greater the number of such cells recruited and the higher the contribution of the neutrophilic leukocytes (NL) into the free cellular population of airways which normally is represented chiefly by alveolar macrophages (AM). Adaptation of the alveolar dust phagocytosis to properties of inhaled particles operates through autoregulation of this process in which a key role is played by macrophage breakdown products (PMB). A series of experiments in vitro and in vivo showed that PMB stimulate AM and NL, enhance their recruitment into airways with a dose-dependent increase of the NL/AM ratio, promote recruitment of their precursors via blood and replenishment of such precursor reserves. The most active factor of the PMB appears to be lipidic by nature. The variability between individuals and between groups of alveolar phagocytosis response to particles of a given cytotoxicity may be due to differences of the host's neurohormonal status. It was shown that influencing the latter significantly shifts response to a standard dose of the PMB.
Monomachy With Cholesterol
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Leisure Corner
Authors: Lester S. King
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tumor Immunology
Authors: Suyu Shu
Journal: JAMA (1997)

Malignant tumors express antigens that may stimulate and serve as targets for antitumor immunity. Virally induced tumors usually contain integrated proviral genomes in their cellular genomes and often express viral genome—encoded proteins that may stimulate specific host immune responses. Antigens unique to individual tumors that stimulate specific rejection of transplanted tumors have been demonstrated only in experimental animals. Other tumor antigens that potentially can stimulate immune responses are shared by different tumors. These include products of mutated or rearranged oncogenes or tumor-suppressor genes. Tumors may also overexpress tissue differentiation antigens or embryonic antigens, which also have the potential to be recognized by the immune system. The recent identification of tumor antigens recognized by cytotoxic T cells opens up new possibilities for constructing chemically defined antigens for specific immunotherapy. Treatment of malignant tumors in humans by immunologic approaches, although theoretically attractive, has not yet succeeded on a large scale. Important progress in immunotherapy of cancer is emerging with several different treatment modalities.
The Pathology, Diagnosis, and Treatment of Cardiac Diseases
Authors: W. O. Markham
Journal: BMJ (1859)

THE stuidy of pathological anatomy-that is to say, the study of the diseased conditions of the different organs and parts of the body as presented to us by the lknife of the anatomist after 'death-is inecessarily one of the stepping-stones over which we must pass to arrive at a perfect understanding of diseased processes.But the physician soon learns that a knowvledge of the nature of diseases is not to be obtained by the mere study of the structural changes of the body.Diseases, as he lknows them, are not simple but complicated processes, involving a chaini, aindI often a long chain, of actions, which run the one into the other; and of these actions, the pathological ana- I
Many physicians following own advice about not smoking
Authors: C. Marwick
Journal: JAMA (1984)

The American Lung Association has designed a community and school-based program that seeks to arm preteenagers with the information needed to say "no" to marijuana. American Lung Association data suggest that marijuana use by Americans has increased 30-fold in 20 years. Of the possible 20 million marijuana smokers in the United States, association officials estimate, 2.7 million are teenagers. Also, these officials say, virtually every American child between ages 12 and 14 years is at some point faced with the decision of whether to smoke marijuana. The purpose of this health education campaign—entitled "Marijuana: A Second Look"—is "to reach children before that time," says James A. Swomley, managing director of the association. "We want to reach the 9-, 10-, and 11-year-old fourth- and fifth-graders who still respond to parental and teacher guidance," he explains. The project is sponsored jointly by the association and by the American Council for Drug Education.
FOR REVENUE ONLY!
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Adaptive response of the enterohepatic circulation of bile acids to extrahepatic cholestasis
Authors: R DUMASWALA
Journal: Hepatology (1996)

Experimental cholestasis induced by ligation of the common bile duct results in morphological and functional changes in the rat hepatocyte. The aim of this study was to evaluate the adaptive response of the transport process involved in the enterohepatic circulation of bile salts to obstructive cholestasis. Male Sprague-dawley rats with common bile duct ligation were killed after 48 and 72 hours. Portal and systemic blood and duodenal aspirates were collected. Taurocholate transport was measured in isolated ileal brush border (BBM) and liver basolateral membranes (BLM). Drastic reduction in intraluminal bile salt concentrations in ligated rats accompanied decreases in saturable taurocholate uptake by ileal BBMs. Kinetic analysis indicated that the decrease was attributable to reduction in transporter density and alteration in affinity for the substrate, both of which accentuated with increase in postligation time. In contrast, despite 20-fold higher portal venous bile salt concentrations, taurocholate uptake by hepatic sinusoidal membrane was lower in rats. Kinetic analysis and immunoblots developed using polyclonal antisera to the liver BLM bile acid transporter demonstrated a gradual decrease in transporter density with increase in postligation time accompanied by reduced taurocholate uptake by basolateral membrane. These results further support the concept that the ileal brush border membrane transporter is regulated by the availability of the substrate, whereas regulation of the bile salt transport across the liver BLM is independent of portal venous bile acid concentration.
Hippocampal and Amygdalar Volumes in Dissociative Identity Disorder
Authors: Eric Vermetten, Christian Schmahl, Sanneke Lindner, Richard J. Loewenstein, J. Douglas Bremner
Journal: American Journal of Psychiatry (2006)

Objective: Smaller hippocampal volume has been reported in several stress-related psychiatric disorders, including posttraumatic stress disorder (PTSD), borderline personality disorder with early abuse, and depression with early abuse. Patients with borderline personality disorder and early abuse have also been found to have smaller amygdalar volume. The authors examined hippocampal and amygdalar volumes in patients with dissociative identity disorder, a disorder that has been associated with a history of severe childhood trauma. Method: The authors used magnetic resonance imaging to measure the volumes of the hippocampus and amygdala in 15 female patients with dissociative identity disorder and 23 female subjects without dissociative identity disorder or any other psychiatric disorder. The volumetric measurements for the two groups were compared. Results: Hippocampal volume was 19.2% smaller and amygdalar volume was 31.6% smaller in the patients with dissociative identity disorder, compared to the healthy subjects. The ratio of hippocampal volume to amygdalar volume was significantly different between groups. Conclusions: The findings are consistent with the presence of smaller hippocampal and amygdalar volumes in patients with dissociative identity disorder, compared with healthy subjects.
Drug control of diuretic-induced hyperuricemia
Authors: A. N. Brest
Journal: JAMA (1966)

ORAL SULFONAMIDE diuretics are the mainstays of the current diuretic armamentarium. In addition to the thiazide derivatives, other potent oral sulfonamide diuretics, including phthalimidine and quinazoline drugs, are currently available. The untoward reactions which may be encountered with these various compounds include electrolyte disequilibriums, systemic idiosyncratic reactions, and metabolic alterations. The last-named include azotemia, hyperglycemia, hyperammoniemia, and hyperuricemia. The purpose of this communication is to describe the frequency, significance, and control of hyperuricemia induced by the quinazoline diuretic quinethazone. The reported incidence of hyperuricemia during oral-sulfonamide-diuretic therapy has varied widely, ranging from 1% to 75%.<sup>1,2</sup>This extreme variability probably reflects differences in patient selection, frequency with which serum-uric-acid determinations have been performed, and, possibly, diet. In addition to primary gout, such diverse organic illnesses as coronary-artery disease, diabetes mellitus, and renal disease may affect serum-uricacid levels. Hence the type of patient population will significantly influence the reported findings. Abundant
Neurology
Authors: Robert J. Joynt
Journal: JAMA (1985)

Molecular biologic techniques are playing an increasing role in the study of neurological diseases, particularly the inherited diseases. Not only are more inherited diseases being identified, but fundamental knowledge about detection, modification, pathophysiology, and putative attempts at therapy are emerging. Many of the autosomal recessive disorders exhibit characteristic markers in the storage of detectable products. This is not the case with many autosomal dominant disorders, for example, Huntington's disease in which there is neuronal degeneration. Despite this, locus assignment of the offending gene is proceeding in various disorders, and if the pedigree conditions are correct, presymptomatic detection can occur, or even prenatal detection as in Duchenne muscular dystrophy.<sup>1</sup>In some genetic diseases more information about the fundamental defect is emerging. For example, in myotonic muscular dystrophy, the fundamental defect may be glucose intolerance with reduced affinity of the insulin receptors.<sup>2</sup>While gene therapy has not yet been tried
One way 'the latest health news' may benefit patients through physicians' response
Authors: M. F. Goldsmith
Journal: JAMA (1988)

HEARTS MAKE NEWS, not only when they're palpitating with political passion but increasingly nowadays because they're revealing their secrets to science. As researchers learn more about such vital topics as the relationship of cholesterol levels and cardiovascular disease, the role of stress in hypertension, and the efficacy of aspirin for preventing myocardial infarction, the news media excitedly relay their pronouncements to the public—frequently with the caveat "before you attempt to apply this information to yourself, see your physician." Using the information may well be a good idea for several reasons, not only the obvious one of self-preservation. The bill for cardiovascular disease—the number one cause of death in this country, with 1 million fatalities attributed to it annually—in the United States is thought to have approximated $85 billion last year (<i>JAMA</i>1988;259:786), including $71 billion in direct health expenses and the rest owing to the indirect costs of disabling and
Osteitis Pubis in Women
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction to: Immunotherapy Utilizing the Combination of Natural Killer– and Antibody Dependent Cellular Cytotoxicity (ADCC)–Mediating Agents with Poly (ADP-ribose) polymerase (PARP) Inhibition
Authors: Kathleen E. Fenerty, Michelle Padget, Benjamin Wolfson, Sofia R. Gameiro, Zhen Su, John H. Lee, Shahrooz Rabizadeh, Patrick Soon-Shiong, James W. Hodge
Journal: Journal for ImmunoTherapy of Cancer (2019)

AbstractFollowing publication of the original article [1], an error was noted in the GAPDH in the western blot depicted in Figure 4b.The original article can be found online at 10.1186/s40425-018-0445-4 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.