tbuckley/cabot-search huggingface dataset:
Poster Session 1: Experimental Cholestasis
Authors: Juan Carlos, Harry Janssen, Elisabeth Plompen, Darwish Sarwa, Massimo Murad, Elwyn Primignani, Jonel Elias, Luc Trebicka, Bettina Lasser, Dominique Hansen, Frank Valla, Kelly Mcdaniel, Fanyin Meng, Heather Francis, Yuyan Han, Julie Venter, Nan Wu, Morgan Quezada, Ying Wan, Shan- Non Glaser, Gianfranco Alpini
Journal: Hepatology (2014)

increased risk of .Conclusions: In this study, blood group non-O was discovered as an independent risk factor for the development of PVT.Interestingly, this factor was not associated with BCS.Blood group non-O is therefore the first discriminant etiological factor described and may be a lead to the unresolved issue of site-specificity of these conditions.
How cost sharing reduced medical spending of participants in the health insurance experiment
Authors: E. B. Keeler
Journal: JAMA (1983)

In a controlled trial of the effects of medical insurance on spending and health status, much less was spent on medical care when patients had to pay for it themselves. They economized by being less prone to seek treatment or be hospitalized for their illnesses. The average cost per hospitalization and per ambulatory episode was the same for all insurance plans. (<i>JAMA</i>1983;249:2220-2222)
AS Disease?
Authors: Paul Heller
Journal: JAMA (1972)

<h3>To the Editor.—</h3> Your EDITORIAL (221:500,1972) on mass screening programs for sickle cell hemoglobin contained many highly controversial statements, but the one that requires urgent correction concerns the designation of the sickle cell trait as a disease. This opinion is not shared by the large majority of hematologists and other knowledgeable physicians working in the field. The use of the term "AS disease," which I hope does not have the editorial endorsement ofThe Journal, is a disservice to the two million black Americans who are heterozygotes for hemoglobin S. Unfortunately, this EDITORIAL accepted the occasional case reports on the coexistence of certain diseases with the sickle cell trait as scientific evidence of a cause-effect relationship. Such generalizations have no greater scientific validity than a statement would have that attributes to all people whose name starts with an "N" and ends with an "n" certain well-defined personality features. The evidence
Hernia.
Authors: Leo M. Zimmerman
Journal: JAMA (1963)

The name of Amos Koontz is closely identified with the subject of hernia, since he has probably written more on the subject than has anyone else in this country. It has long been anticipated that his many articles would be combined in book form and his friends have pressed him to bring out such a volume. His book has finally appeared. This small monograph is written in an informal and conversational style which reflects the genial personality of its author. It is also singularly free from strong bias and enthusiasm for any particular operative method. Koontz includes a large number of operative techniques in his armamentarium and selects them to suit the needs of the individual case. He quotes Finney to the effect, "Make your operation fit the patient. Don't try to make the patient fit your operation." Over the span of many years Koontz has been interested in various
Possible Neurologic Effects of Aspartame, a Widely Used Food Additive
Authors: Timothy J. Maher, Richard J. Wurtman
Journal: Environmental Health Perspectives (1987)

The artificial sweetener aspartame (L-aspartyl-L-phenylalanyl-methyl ester), is consumed, primarily in beverages, by a very large number of Americans, causing significant elevations in plasma and, probably, brain phenylalanine levels. Anecdotal reports suggest that some people suffer neurologic or behavioral reactions in association with aspartame consumption. Since phenylalanine can be neurotoxic and can affect the synthesis of inhibitory monoamine neurotransmitters, the phenylalanine in aspartame could conceiveably mediate neurologic effects. If mice are given aspartame in doses that elevate plasma phenylalanine levels more than those of tyrosine (which probably occurs after any aspartame dose in humans), the frequency of seizures following the administration of an epileptogenic drug, pentylenetetrazole, is enhanced. This effect is simulated by equimolar phenylalanine and blocked by concurrent administration of valine, which blocks phenylalanine's entry into the brain. Aspartame also potentiates the induction of seizures by inhaled fluorothyl or by electroconvulsive shock. Perhaps regulations concerning the sale of food additives should be modified to require the reporting of adverse reactions and the continuing conduct of mandated safety research.
Splenoportography
Authors: M. G. Baron
Journal: JAMA (1968)

In 1951, Abeatici and Campi<sup>1</sup>demonstrated that there was free vascular communication between the splenic pulp and the portal venous system. Soon thereafter, Leger<sup>2</sup>performed the first successful splenoportogram in a human. Contrast material injected directly into the substance of the spleen flowed rapidly through multiple venous radicles into the splenic vein and then into the portal vein and liver, opacifying these structures in turn. In the past 15 years, percutaneous splenoportography has come into wide use and has made a major contribution in delineation of the pathologic anatomy and hemodynamics in patients with portal hypertension.<sup>3-6</sup> The portal vein (Fig 1) is formed by the confluence of the splenic and superior mesenteric veins behind the neck of the pancreas overlying the vertebral bodies of L-1 and L-2. The portal vein courses upward and to the right behind the first portion of the duodenum and enters the liver
Practical Text-Book of Midwifery, for Nurses and Students.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Biologic Activity of Cold-Reacting Autoantibodies
Authors: Waldemar Pruzanski, Kenneth H. Shumak
Journal: New England Journal of Medicine (1977)

Reactions of Non-Erythroid Cells with Cold AgglutininsRecently, it has been shown that cold agglutinins react with Ii antigens on many types of normal and malignant cells in addition to red cells. In the presence of complement, the interaction of cold agglutinins with these cells in vitro leads to the death of the cells and sometimes to lysis. Cytotoxic cold-reacting antibodies distinguishable from cold agglutinins have also recently been recognized.LymphocytesIn 1966, Franks reported that anti-I and anti-i cold agglutinins were absorbed at 4°C by adult human leukocytes, suggesting that these cells possess the I . . .
Still more on streptococcal pharyngitis: an important disease with yet unresolved clinical issues
Authors: V. A. Fulginiti
Journal: JAMA (1985)

The report by Krober et al<sup>1</sup>in this issue ofThe Journalkeeps alive the controversies that have surrounded the management of group A β-hemolytic streptococcal pharyngitis (GABS) in clinical practice. The physicians from the Tripler and Madigan Army Medical Centers have shown that early penicillin treatment resulted in significant clinical improvement when contrasted to a 72-hour delay in the initiation of penicillin treatment. This issue has also recently been addressed with the reincarnation of a study by John Nelson<sup>2</sup>performed in 1958-1959, and reported in 1984. Both studies suggest that early treatment improves clinical symptoms, despite expert statements and studies to the contrary. The "standard" management of streptococcal pharyngitis has been a mainstay of infectious disease dogma for decades. Physicians were comfortable with the liberal use of the throat culture in children with sore throats and their contacts; in some cases of recurrent disease, even pets were
Eye Injuries
Authors: Joel G. Sacks
Journal: JAMA (1971)

The definitive care of ocular injuries is obviously the province of the specially trained ophthalmologist. However, in this day of industrial, automotive, and military injuries it is frequently the general surgeon who sees the patient first, and it is essential that he have at least some knowledge of the initial management of ocular injuries and that he be aware of some of the late ocular complications of head trauma. The author of this book has attempted to write a reference text for ophthalmologists and for general surgeons who deal with ocular trauma. When the author is writing from his first-hand experience (which is obviously large), he is at his best. However, in an attempt to be complete, he has included many entities that bear little relationship to ocular injuries; for example, flicker fusion perimetry, dyslexia, psychodynamics of self-mutilation. Further, he has devoted very little space to such everyday trauma as
A Correction
Authors: Eric Beatty, Connaught Edge, N Collins, Inniskilling Fusil, Counity Collins Of Laghey, Charles Mcconaghey, John Jack, William Wyatt, Randolph Noel, Churchill Murray, Inniskilling Royal, G Fusiliers, E Not', R Mr
Journal: BMJ (1916)

suddenly on May 8th at Belfast of heart failure, following his exertions in Dublin during the rebellion.He had served in South Africa, anid hela the Queeni's medal with four clasps.He had retired from the army for some years, but rejoined when the war broke out, and was attached to tlje Royal Irish Rifles.
Dysphagia megalatriensis
Authors: B. T. Le Roux, M. A. Williams
Journal: Thorax (1969)

Death from haematemesis is recorded in a patient with a giant left atrium which had caused dysphagia of such severity that a plastic naso-gastric feeding tube had been introduced and retained for some days. Vascular causes of dysphagia are briefly reviewed. It is thought that the rarity of dysphagia with left atrial enlargement justifies its recognition by a new term.
Mosaic analysis of insulin receptor function
Authors: T. Kitamura
Journal: Journal of Clinical Investigation (2004)

Insulin promotes both metabolism and growth. However, it is unclear whether insulin-dependent growth is merely a result of its metabolic actions. Targeted ablation of insulin receptor (Insr) has not clarified this issue, because of early postnatal lethality. To examine this question, we generated mice with variable cellular mosaicism for null Insr alleles. Insr ablation in approximately 80% of cells caused extreme growth retardation, lipoatrophy, and hypoglycemia, a clinical constellation that resembles the human syndrome of leprechaunism. Insr ablation in 98% of cells, while resulting in similar growth retardation and lipoatrophy, caused diabetes without β-cell hyperplasia. The growth retardation was associated with a greater than 60-fold increase in the expression of hepatic insulin-like growth factor binding protein-1. These findings indicate that insulin regulates growth independently of metabolism and that the number of insulin receptors is an important determinant of the specificity of insulin action.
Physician-Controlled Utilization Management
Authors: Eve A. Kerr
Journal: Annals of Internal Medicine (1996)

Letters1 May 1996Physician-Controlled Utilization ManagementEve A. Kerr, MD, MPH, Robert H. Brook, MD, ScD, and Brian S. Mittman, PhD, MDEve A. Kerr, MD, MPHUniversity of California, Los Angeles; Los Angeles, CA 90095-1736RAND; Santa Monica, CA 90407-2138Veterans Affairs Medical Center; Sepulveda, CA 91343Search for more papers by this author, Robert H. Brook, MD, ScDUniversity of California, Los Angeles; Los Angeles, CA 90095-1736RAND; Santa Monica, CA 90407-2138Veterans Affairs Medical Center; Sepulveda, CA 91343Search for more papers by this author, and Brian S. Mittman, PhD, MDUniversity of California, Los Angeles; Los Angeles, CA 90095-1736RAND; Santa Monica, CA 90407-2138Veterans Affairs Medical Center; Sepulveda, CA 91343Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-124-9-199605010-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We agree with Dr. Temianka that utilization management that is conducted thoughtfully and grounded in evidence-based medicine can often both control costs (by decreasing utilization) and increase appropriateness of care. In fact, RAND has been at the forefront in documenting the inappropriate overutilization of many procedures [1, 2]. In describing the variability of utilization management methods currently used by capitated physician groups, we sought to help physicians focus on methods that are most valid and would help physicians produce the most value for the cost.We also agree that current guidelines are numerous and vary in quality. We ...References1. Hilborne LH, Leape LL, Bernstein SJ, Park RE, Fiske ME, Kamberg CH, et al. The appropriateness of use of percutaneous transluminal coronary angioplasty in New York state. JAMA. 1993; 269:761-5. Google Scholar2. Winslow CM, Kosecoff JB, Chassin M, Kanouse DE, Brook RH. The appropriateness of performing coronary artery bypass surgery. JAMA. 1989; 260:505-9. Google Scholar3. Field MJ, Lohr KN. Guidelines for Clinical Practice. Washington, DC: National Academy PR; 1992. Google Scholar Author, Article, and Disclosure InformationAuthors: Eve A. Kerr, MD, MPH; Robert H. Brook, MD, ScD; Brian S. Mittman, PhD, MDAffiliations: University of California, Los Angeles; Los Angeles, CA 90095-1736RAND; Santa Monica, CA 90407-2138Veterans Affairs Medical Center; Sepulveda, CA 91343 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1996Volume 124, Issue 9Page: 856KeywordsEvidence based medicineHealth care qualityPatientsTreatment guidelines ePublished: 15 August 2000 Issue Published: 1 May 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Abstract O.61: Coronary Artery Stenosis Risk and Progression in Kawasaki Disease Patients: Experience at a U.S. Tertiary Pediatric Center
Authors: Alok Patel, Margaret Bruce, Whitney Harrington, Michael Portman
Journal: Circulation (2015)

Objective: Risk and natural progression of coronary artery stenosis in Kawasaki Disease is not well-defined and is a potential cause of long term morbidity, despite treatment with IVIG. We present a novel study at a US tertiary pediatric care center identifying risk factors for stenosis. Methods: We reviewed charts of all children that underwent cardiac catheterization for coronary artery abnormalities from 1998 to January 2014 at a tertiary pediatric care center. All demographic and diagnostic data was recorded including time intervals to echocardiographic changes and catheterization confirmed cases of stenosis. Multivariate survival analysis was used to identify risk factors with stenosis formation as the main outcome measure. Results: Fifty-two children met inclusion criteria and 18 (34.6%) developed stenosis. The highest risk group overall were children under the age of 6 months (HR 3.66, p=0.005) and those with giant coronary aneurysms (GCA). In a subset of only cases of GCA (33), children under the age of six months were at highest risk (HR 2.62, p=0.04). IVIG administration, gender, and ethnicity were statistically insignificant. The majority of individuals with GCA went on to develop stenosis (19/33). The presence of GCA was 100% sensitive for cases of stenosis. Conclusions: This is a novel study in an American population and demonstrates a relatively high incidence of stenosis in children with KD and coronary vascular abnormalities. Overall, a majority of GCA cases progressed into stenosis, with children under the age of 6 months being at highest risk.
Psychotherapy reduces disability, saves money
Authors: L. Lamberg
Journal: JAMA (1997)

REPORTS OF psychotherapy's death are greatly exaggerated, its proponents say. Psychotherapy works. It saves money for patients and insurers. It improves job and social performance, prevents lost workdays, reduces the inappropriate use of other medical services, and enhances quality of life, the American Psychiatric Association (APA) Commission on Psychotherapy by Psychiatrists (COPP) asserted, offering a wealth of data to support these claims at the APA annual meeting in San Diego, Calif, in May. "The social costs of untreated psychiatric illness are enormous," said Norman Clemens, MD, COPP chair, clinical professor of psychiatry at Case Western Reserve University, Cleveland, Ohio, and a member of the APA Board of Trustees. "These disorders not only harm individuals in their work and family lives but also reverberate through society," he said. "This is dramatically apparent in the welfare and criminal justice systems." <h3>Relic or Potential Help?</h3> With increasingly effective psychotropic medications and unrelenting pressure
Lectures on the Principles of Surgical Diagnosis: Especially in Relation to Shock and Visceral Lesions
Authors: F. Le Gros Clark
Journal: BMJ (1868)

PRESIDENT AND GENTLEMEN,-There are certain effects of in- jury to the head, apart from lesions of the encephalic centre, to the diagnosis of which I will now briefly advert, before discussing the symptoms of direct injury to the brain itself.Although I have verified, from repeated observation, the impunity with which fissure of the skull may be sustained, my own experience has likewise confirmed the observation of others, that blows, unattended
Designing prevention programmes to reduce incidence of dementia: prospective cohort study of modifiable risk factors
Journal: BMJ (2010)

Objective To estimate the percentage reduction in incidence of dementia that would be obtained if specific risk factors were eliminated.Design Prospective seven year cohort study.Setting General population, Montpellier, France.Participants 1433 people aged over 65 with a mean baseline age of 72.5 (SD 5.1) years.Main outcome measures Diagnosis of mild cognitive impairment or dementia established by a standardised neurological examination.Results Cox models were constructed to derive hazard ratios and determine confounding and interaction effects for potentially modifiable risk factors for dementia.Mean percentage population attributable fractions were calculated with 95% confidence intervals derived from bootstrapping for seven year incidence of mild cognitive impairment or dementia.The final model retained crystallised intelligence (population attributable fraction 18.11%, 95% confidence interval 10.91% to 25.42%), depression (10.31%, 3.66% to 17.17%), fruit and vegetable consumption (6.46%, 0.15% to 13.06%), diabetes (4.88%, 1.87% to 7.98%), and apolipoprotein E ε4 allele (7.11%, 2.44% to 11.98%).Conclusions Increasing crystallised intelligence and fruit and vegetable consumption and eliminating depression and diabetes are likely to have the biggest impact on reducing the incidence of dementia, outweighing even the effect of removing the principal known genetic risk factor.Although causal relations cannot be concluded with certainty, the study suggests priorities that may inform public health programmes.
PDTM-11. YAP1 IS NECESSARY FOR TUMORIGENESIS AND CANCER STEM CELLMAINTENANCE IN SHH-INDUCED MEDULLOBLASTOMAS
Authors: Sivaraman Natarajan, Joshy George, James M Olson, Fernando Camargo, Kyuson Yun
Journal: Neuro-Oncology (2017)

Anti-cancer treatments with minimal adverse effects are particularly important for pediatric brain tumor patients to preserve normal brain development and function. We propose that SHH medulloblastomas may be safely treated with a YAP1 inhibitor. YAP1, a transcriptional effector of the Hippo signaling pathway, is amplified or over-expressed specifically in the SHH subgroup of medulloblastomas. To directly test whether this observation reflects significant functional interaction between the SHH pathway and YAP1, we genetically deleted Yap1 in a mouse model of SHH-induced medulloblastoma, SMO-M2;GFAP-Cre. All SMO-M2;GFAP-Cre mice succumb to medulloblastomas by weaning age. However, when Yap1 is genetically deleted, ~50% of Yap1f/f; SMO-M2;GFAP-Cre mice are rescued from medulloblastoma formation. Analyses of young pups indicate that Yap1is dispensable for tumor initiation but necessary for tumor maintenance. Considering its known function in stem cell homeostasis, we hypothesized that Yap1 may be necessary to maintain cancer stem cells (CSCs). To test this, we isolated and manipulated Yap1 levels in tumorspheres from two different SHH medulloblastoma models: Ptch+/-;p53 and SMO-M2;GFAP-Cre. 100% of SMO-M2;GFAP-Cre tumors generated tumorsphere cultures that can be passaged for > 10 passages. In contrast, all Yap1-null cultures from Yap1f/f; SMO-M2;GFAP-Cre mice quickly exhausted their self-renewal ability by passage 3. Furthermore, either siRNA or a small molecule inhibitor (verteporfin) treatment in established Ptch+/-;p53 or SMO-M2;GFAP-Cre tumorspheres significantly reduced the number of secondary spheres, indicating that Yap1function is necessary to maintain SHH medulloblastoma CSCs. To determine whether YAP1 inhibition has potential therapeutic value, we treated SMO-M2;GFAP-Cre pups with verteporfin in vivo and observed significant increase in overall survival. Importantly, neither verteporfin treatment nor genetic deletion of Yap1 showed gross adverse effects in brain development or neural stem cell function, indicating a clear therapeutic window. In summary, this study provides compelling evidences that YAP1 inhibitors may provide significant therapeutic benefit to treating SHH medulloblastomas.
BUDAPEST
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal