tbuckley/cabot-search huggingface dataset:
Incorrect Wording
Authors: J H Halpern
Journal: JAMA (1999)

In the Medical News &amp; Perspectives article entitled "New Marijuana Laws in 2 States Prompt Caution" published in the December 11, 1996, issue of THE JOURNAL (1996;276:1786-1787), the words "and methamphetamine" should be deleted from the end of the second sentence of the 12th paragraph.
Section 49.—Sickle Cell Disease and Related Hemoglobinopathies
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
In Reply:
Authors: Guido Sauter, Ronald Simon, Khawla Al-Kuraya, Luigi Terracciano
Journal: Journal of Clinical Oncology (2005)

In a Letter to the Editor regarding our previous article 1 in the Journal of Clinical Oncology, Arroyo et al describe KIT expression in three of 50 gallbladder carcinomas.Although this result is not significantly different from our previous data (zero of 20 positive; P ϭ .15),these data raise a number of important issues.First, since immunohistochemistry (IHC) data are increasingly driving treatment decisions, it is vital to understand that IHC results from different laboratories can hardly be compared with each other.Differences in antibody selection, IHC protocols, and staining interpretation often result in highly discrepant results.This also applies for differences in tissue processing, which cannot be eliminated by using standardized US Food and Drug Administration-approved reagents.For example, Arroyo et al used a microwave slide pretreatment followed by overnight incubation.Although detailed information on critical experimental conditions (eg, incubation temperature) are not provided, the Arroyo protocol clearly differs from our procedure, which included a 3-minute pressure cooker pretreatment and 2.5 hours of room temperature incubation. 1 This procedural divergence alone could explain major variations of staining results between our study 1 and the study by Arroyo et al.In fact, given the notorious variability of IHC data, the major value of the data set provided in our previous study is the unusually high degree of standardization (for IHC studies), ie, the simultaneous analysis of samples from more than 120 different tumor entities in a single experiment under identical experimental conditions.This permits comparability of the expression levels and frequency between different tumor categories.
Thyroid storm with normal serum triiodothyronine level during diabetic ketoacidosis
Authors: N. Ahmad
Journal: JAMA (1981)

IT IS now established that nonthyroidal illness can alter thyroid hormone metabolism in such a way that the serum level of triiodothyronine (T<sub>3</sub>) is decreased and the level of reverse triiodothyronine (rT<sub>3</sub>) is elevated in otherwise euthyroid persons.<sup>1</sup>The list of such nonthyroidal illnesses in which these findings occur has been growing. In patients with hyperthyroidism and intercurrent, nonthyroidal illness, the serum T<sub>3</sub>level may be normal or even less than normal and there is a concomitant increase in the rT<sub>3</sub>level.<sup>2-4</sup>Although one recent report describes a patient with diabetic ketoacidosis, hyperthyroidism, and a normal T<sub>3</sub>level,<sup>4</sup>and another describes a patient in whom thyroid storm developed postoperatively and who at that time had a normal T<sub>3</sub>level,<sup>5</sup>the occurrence of thyroid storm in a patient with a normal T<sub>3</sub>level and severe intercurrent illness has not been
Correction: Hypokalaemia and diuretics
Authors: Harold Ellis, Nalin Perera
Journal: BMJ (1980)

not prevented swarms of bright young Welsh graduates from going elsewhere, particularly to London, for further training or employment; nor has it succeeded in seeding the general practices in Wales with fresh supplies of Welsh doctors.Dr Jones would obviously like to direct labour, but I am afraid that shutting down medical schools in London will not help to staff other parts of our islands.
Applied Microbiology, Baltimore
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Perinatal Mortality and Congenital Malformations in Infants Born to Women With Insulin-Dependent Diabetes Mellitus—United States, Canada, and Europe, 1940-1988
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diagnosis of Significant Bacteriuria in Pregnancy
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Predictors of Marijuana Use in Adolescents Before and After Licit Drug Use: Examination of the Gateway Hypothesis
Authors: Ralph E. Tarter, Michael Vanyukov, Levent Kirisci, Maureen Reynolds, Duncan B. Clark
Journal: American Journal of Psychiatry (2006)

Objective: The authors investigated whether the transition from licit drug use to marijuana use is determined by particular risk factors, as specified by the gateway hypothesis. They also evaluated the accuracy of the "gateway sequence" (illicit drug use following licit drugs) for predicting a diagnosis of substance use disorder. Method: Boys who consumed licit drugs only (N=99), boys who consumed licit drugs and then transitioned to marijuana use (gateway sequence) (N=97), and boys who used marijuana before using licit substances (alternative sequence) (N=28) were prospectively studied from ages 10–12 years through 22 years to determine whether specific factors were associated with each drug use pattern. The groups were compared on 35 variables measuring psychological, family, peer, school, and neighborhood characteristics. In addition, the utility of the gateway and alternative sequences in predicting substance use disorder was compared to assess their clinical informativeness. Results: Twenty-eight (22.4%) of the participants who used marijuana did not exhibit the gateway sequence, thereby demonstrating that this pattern is not invariant in drug-using youths. Among youths who did exhibit the gateway pattern, only delinquency was more strongly related to marijuana use than licit drug use. Specific risk factors associated with transition from licit to illicit drugs were not revealed. The alternative sequence had the same accuracy for predicting substance use disorder as the gateway sequence. Conclusions: Proneness to deviancy and drug availability in the neighborhood promote marijuana use. These findings support the common liability model of substance use behavior and substance use disorder.
Quantitative systematic review of topically applied non-steroidal anti-inflammatory drugs
Journal: BMJ (1998)

Objective: To compare risk of myocardial infarction associated with smoking in men and women, taking into consideration differences in smoking behaviour and a number of potential confounding variables.Design: Prospective cohort study with follow up of myocardial infarction.Setting: Pooled data from three population studies conducted in Copenhagen.Subjects: 11 472 women and 13 191 men followed for a mean of 12.3 years.Main outcome measures: First admission to hospital or death caused by myocardial infarction.Results: 1251 men and 512 women had a myocardial infarction during follow up.Compared with non-smokers, female current smokers had a relative risk of myocardial infarction of 2.24 (range 1.85-2.71)and male smokers 1.43 (1.26-1.62);ratio 1.57 (1.25-1.97).Relative risk of myocardial infarction increased with tobacco consumption in both men and women and was higher in inhalers than in non-inhalers.The risks associated with smoking, measured by both current and accumulated tobacco exposure, were consistently higher in women than in men and did not depend on age.This sex difference was not affected by adjustment for arterial blood pressure, total and high density lipoprotein cholesterol concentrations, triglyceride concentrations, diabetes, body mass index, height, alcohol intake, physical activity, and level of education.Conclusion: Women may be more sensitive than men to some of the harmful effects of smoking.Interactions between components of smoke and hormonal factors that may be involved in development of ischaemic heart disease should be examined further. Table 1 Overview of study population Cohort of origin* No of women No of men Year of examination Age at examination No of myocardial infarctionsCopenhagen city heart study
Abstract P336: Are Post-Operative Length-of-Stay and Rehospitalization Linked to Caregiving among Cardiac Surgery Patients?
Authors: Heidi Mochari-Greenberger, Matthew Mosca, Brooke Aggarwal, Tianna M Umann, Lori Mosca
Journal: Circulation (2012)

Background: Cardiac surgery patients are frequently cared for by family members or paid aides, potentially impacting clinical outcomes, yet data are sparse. The purpose of this study was to evaluate the association between access to paid or informal (unpaid) caregiving among cardiac surgery patients and post-operative length-of-stay, and death or rehospitalization at 1 year. Methods: We prospectively studied 665 consecutive patients admitted for cardiac surgery at a university hospital as part of a NHLBI-sponsored clinical outcomes study (93% participation rate). Participants (mean age 65 years; 35% female; 21% minority) completed an interviewer-assisted questionnaire at baseline to determine if they had a caregiver and the extent of care received. A hospital-based clinical information system was used to document post-operative length-of-stay and death or rehospitalization at 1 year (supplemented by standardized questionnaire). Demographics and comorbid conditions were documented by electronic chart assessment; comorbidity score was calculated using the Ghali comorbidity index. Associations between caregiving and clinical outcomes were evaluated by multiple logistic regression, adjusted for demographics (age, race, sex, marital status, health insurance) and comorbid conditions. Results: At baseline, 28% (183/665) of cardiac surgery patients reported having a caregiver (8% paid; 20% informal only). Having a caregiver was significantly associated with longer (&gt;7 days) post-operative length-of-stay (OR=1.86; 95%CI=1.30−2.65). This association varied by whether patients had a paid (OR=3.00; 95%CI=1.57−5.74) or informal caregiver (OR=1.55; 95%CI=1.04−2.31) versus none and was attenuated after multivariable adjustment ( paid caregiver OR=2.15; 95%CI=1.02−4.52, informal caregiver OR=1.23;95%CI=0.78−1.95). Having a paid caregiver was significantly associated with death or rehospitalization at 1 year in univariate analysis (OR=2.09; 95%CI=1.18−3.69) and was significantly attenuated after multivariable adjustment (OR=1.40; 95%CI=0.74−2.62). There was a non-significant univariate association between having an informal caregiver and death or rehospitalization at 1 year (OR=1.39; 95%CI=0.94−2.06). Conclusions: Cardiac surgery patients who identified having a caregiver had longer post-operative stays and a higher rate of death or rehospitalization at 1 year compared to those without a caregiver, not fully explained by comorbidities/confounders. These data suggest that assessment of caregiver status may be a powerful predictor and a simple method to identify cardiac surgery patients at risk for adverse clinical outcomes.
Alzheimer Memoir
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Air-quality standards
Authors: M. Bader
Journal: JAMA (1980)

<h3>To the Editor.—</h3> Although I assume 4 mg to be the dose of chlorpheniramine maleate used in the study "Effectiveness of Antihistamines in the Symptomatic Management of the Common Cold" by Howard et al (242:2414, 1979), it seems a significant oversight that the dose is never mentioned. For a well-designed study, it is a glaring omission.
PTU-165 The Better Definition of Nodal Staging in the 7Th Edition of TNM Manual does not Predict Survival or Translates into better Prognosticating Ability in Oesophago-Gastric Junctional Adenocarcinoma
Authors: R Y Kannan, M Davies, C Jenkins, A Rasheed
Journal: Gut (2013)

<h3>Introduction</h3> The 7th TNM staging defines a minimum number of nodes, recommends an optimal number for each T stage, emphasises the prognostic importance of number of regional nodes involved and upstages based on the number of metastatic lymph nodes. We intend on studying the impact of application of 7th TNM rules on nodal staging (N) of resected and pathologically reported oesophago-gastric junctional (OGJ) adenocarcinomas during the last 10 years stratifying them according to the 7th edition TNM staging and to compare against the original staging and assess possible impact of nodal neo-staging on survival. <h3>Methods</h3> A retrospective database was used to capture the clinico-pathological data of all consecutive curative resections of OGJ adenocarcinomas over the last 10 years in two UK Upper GI Units. Any report with less than 12 lymph nodes was considered inadequate and denoted as (Nx). All cases were re-reported and re-staged according to the 7th TNM staging rules. We compared the impact of the 7th TNM staging rules on neo-staging. Overall survival was analysed using the 6th and 7th TNM staging respectively. Overall survival was sub-stratified into 2 years, 5 years and 10 years post curative resection. <h3>Results</h3> Fifty seven (57) pathology reports confirming OGJ adenocarcinomas were reviewed. Adequate lymphadenectomy (minimum of 12 nodes) was noted in 33 patients. Overall stage migration was noted in 36 (63%) reports with the 7th TNM staging. Of those who had adequate lymphadenectomy (33), 20 reports(60.6%) had stage migration. Survival was calculated from the time of initial surgery. Two year survival was assessed in the whole group (n = 57). Five year survival for patients operated between 2000 to 2007 (n = 34) and 10 year survival for those operated on between 2000 to 2002 (n = 10). For stage 3b and stage 3c (7th TNM) there was a 12.5%, 8.9% and 8.9% higher survival rate respectively (for 2.5 and 10 years), compared to the original 6th TNM staging for stage 3. Correspondingly for stage 1b, the survival rate was 5.3%, 3.6% and 3.6% respectively. <h3>Conclusion</h3> The 7th edition of TNM staging provides a detailed documentation of the lymphatic staging. This better defined lymphatic staging does not seem to predict survival or have a superior prognosticating ability. <h3>Disclosure of Interest</h3> None Declared
PROPRIETARY MEDICINES.
Authors: A. JACOBI
Journal: JAMA (1906)

Goethe once said that the most interesting book that could be written would be a treatise on human errors. In that book, large like a library, the history of quackery—well meant or deceitful—would fill a large place. The distrust of medicine and its powers is as old as the world, for not many ever knew or cared to appreciate what medical science or art is capable or not of accomplishing, or should be held responsible for. Besides, the more uncultured or uncontrolled the human intellect the greater is the predominance of mysticism. In Greece quackery was rife and Aristophanes made it the subject of ridicule. The elder Cato, who advised the use of cabbage against all sorts of disease and employed witchcraft and incantations for luxations, demanded the expulsion from Rome of the Greek physicians. The iatromechanics, who taught the direct interdependence of stars and man and prescribed pills compounded
Female Athletics
Authors: Richard W. Corbitt
Journal: JAMA (1974)

THE Committee on the Medical Aspects of Sports reiterates<sup>1</sup>the beneficial aspects of sports and exercise participation for girls and women. Female participation in such programs previously was discouraged due to societal and cultural stereotypes that considered such participation a departure from the "traditional role." Much to the contrary, physiological and social benefits are to be gained by girls and women through physical activity and sports competition. In many cases, vigorous physical activity improves the distinctive biological functions of the female. Usually, dysmenorrhea is unaffected by sports participation or subsides as a result of such participation.<sup>2,3,4,5,6</sup>Exercise can also improve regulation of the menstrual cycle. Following active sports involvement of international caliber, female athletes have experienced a greater number of complication-free pregnancies and greater ease of delivery than recorded for a normal but less physically active control group.<sup>3(pp66-68),7,8</sup>These specific benefits often accrue to female athletes quite