tbuckley/cabot-search huggingface dataset:
Abstract 4288: Race specific differences in G-protein decoupling from CCR9 in prostate cancer cells contribute to the differences in docetaxel response
Authors: Neeraj Kapur, Hina Mir, Shailesh Singh
Journal: Cancer Research (2019)

Abstract Current treatment approaches have failed to reduce racial disparity in treatment outcome of prostate cancer (PCa) primarily due to the race-specific difference in the biology of PCa. Therefore, identification of race-specific molecular differences is needed to address the disparity in treatment outcome. In this study, we have determined the race-specific differences in CCR9 signaling. Phospho-proteomic profile of key pro-survival molecules following CCL25 treatment in African American (AA) and European American (EA) PCa cells was determined using antibody microarray and validated by western blot analyses. Coupling and decoupling of G-protein(s) with CCR9 in response to CCL25, which determines downstream signaling of CCR9 was ascertained by immunoprecipitation assay (IPA). Cell viability and apoptosis in response to a taxane drug docetaxel (DTX), with/without CCL25 stimulation and CCR9-blockade, were examined using MTT and flow cytometry, respectively. Levels of pro-apoptotic proteins were determined by western blot analyses. Our data show differential G-protein(s) decoupling from CCR9 in AA and EA cells. CCR9-activation dissociated Gαi2/3/Gαq/ Gα13/Gβ1γ7 –proteins in AA cells compared to Gαs/Gβ2γ9 and Gα13/Gαs/G β1/β3γ7 in EA cells, respectively, contribute to different molecular mechanisms supporting cell survival in cell lines derived from two races. Race-specific G-protein signaling in PCa cells, following CCL25 stimulation, is reflected into hyper-activation of molecules involved in PI3K/Akt and MEK/Erk1/2 signaling, which are associated with PCa aggressiveness in AA cells compared to EA counterparts. Further, activation of CCR9-CCL25 axis significantly influences the therapeutic response of PCa cells against DTX, which is highly compromised in AA cells compared to EA cells following CCL25 stimulation. However, this protective effect of CCL25 was abrogated after CCR9 blockade. Inhibition of MEK/Erk1/2 axis significantly improved DTX-induced cell death in AA cells, suggesting the importance of this axis in reducing drug response. Further, stimulation with CCL25, exclusively downregulated cleaved caspase-7, 8 and Bim in response to DTX in AA cells. In all, differential decoupling of G-proteins from CCR9 controls the downstream signaling and therefore determines disparity associated with PCa outcome and offer novel race-specific therapeutic targets for PCa. Citation Format: Neeraj Kapur, Hina Mir, Shailesh Singh. Race specific differences in G-protein decoupling from CCR9 in prostate cancer cells contribute to the differences in docetaxel response [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4288.
Erratum: Methyltransferase Dnmt3a upregulates HDAC9 to deacetylate the kinase TBK1 for activation of antiviral innate immunity.
Authors: Xia Li, Qian Zhang, Yuanyuan Ding, Yiqi Liu, Dezhi Zhao, Kai Zhao, Qicong Shen, Xingguang Liu, Xuhui Zhu, Nan Li, Zhongyi Cheng, Guoping Fan, Qingqing Wang, Xuetao Cao
Journal: Nature Immunology (2016)
THE GROWING IMPORTANCE OF PHYSICS IN MEDICINE.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Milroy Lectures ON THE HYGIENIC ASPECT OF THE COAL-MINING INDUSTRY IN THE UNITED KINGDOM: Delivered before the Royal College of Physicians of London
Authors: F. Shufflebotham
Journal: BMJ (1914)

of the case?It mlust be admitted thatlot even tlle pre- sncce of pus cells and organismls in tlle c-rebro-spinal fluid are suifficient evidenlce for a diagnosis of meniingitis, as it lias been proved thlat the same may be fotiuid in cases of uinconmplicated abscess of thle braini or in extradural abscess.In the absence of r)ost-miortem evidence ve cannot be certain that there existed a true meningitis, buit the important practical point is tbat, even when all the classical signs of meningitis are fully developed and are confirmed by the finding of pus cells and organisms in the cerebro-spinal fluid, there is still a possibility of recovery uinder energetic surgical treat-ment.No vaccines wvere used in the treatment of this case.
Mental Handicaps in Golf.
Journal: JAMA (1927)

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Hospitals, Chicago
Journal: JAMA (1964)

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Changing Patterns of Groups at High Risk for Hepatitis B in the United States
Journal: JAMA (1988)

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Review of Published Studies of Orally Administered Asbestos
Authors: Lyman W. Condie
Journal: Environmental Health Perspectives (1983)

There has been great public concern about the adverse health effects resulting from the presence of asbestos fibers in municipal drinking water supplies. This article reviews and summarizes the experimental findings of 11 published papers that have evaluated the carcinogenic potential of asbestos following its ingestion. The long-term, high-level ingestion of various types of asbestos fibers in more than one animal species failed to produce any definite, reproducible, organ-specific carcinogenic effect.
BUENOS AIRES
Journal: JAMA (1924)

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The Parotid Picture, 1962
Journal: JAMA (1963)

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Pneumococcal Vaccine
Authors: Carol Brignoli Gable
Journal: JAMA (1990)

We evaluated the efficacy and cost savings of the pneumococcal pneumonia vaccine in a retrospective cohort study of 762 vaccinated and 1161 randomly selected unvaccinated age-sex matched persons in Blue Cross/Blue Shield of Minnesota using medical and pharmaceutical claims. The pneumonia incidence and the ratio of incidence in the postvaccination to prevaccination periods (rate ratio) were examined in the vaccine group by sex and risk factors. Vaccination significantly reduced pneumonia incidence, with overall efficacy of 69% and higher efficacy in women (86%) than in men (33%). We assigned persons to risk categories based on disease conditions as recorded in the claims by the<i>ICD-9-CM (International Classification of Diseases, Ninth Revision, Clinical Modification)</i>diagnostic codes. In the risk categories, efficacy varied from 50% to 75% and was confounded by sex. Immunocompromised and immunocompetent women had high efficacy (83% to 88%), while immunocompetent and immunocompromised men had lower efficacy (33%). Persons with a precondition of pneumonia exhibited similar vaccine efficacy to the overall cohort relative to the comparison group. Projected costs of pneumonia cases are 3.6 times the observed costs of vaccination and postvaccination pneumonia costs. We conclude that the pneumococcal pneumonia vaccine is efficacious in persons having had pneumonia, persons "at risk" of developing pneumonia, or persons over 50 years of age, and it corresponds to overall savings of $141 per person. (<i>JAMA</i>. 1990;264:2910-2915)
SAUCE, PICKLES, AND CHAMPAGNE
Journal: JAMA (1967)

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JAMES LIND (1716-1794) PHYSICIAN TO THE FLEET
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prostate stem cell antigen (PSCA) and risk of bladder cancer: linking genotypes to functional mechanisms
Authors: Adam Mumy, Indu Kohaar, Patricia Porter-Gill, Wei Tang, Yi-Ping Fu, Ludmila Prokunina-Olsson
Journal: Genome biology (2011)

Deep exome resequencing is a powerful approach for delineating patterns of protein-coding variation among genes, pathways, individuals and populations.We analyzed exome data from 2,440 individuals of European and African ancestry as part of the National Heart, Lung, and Blood Institute's Exome Project, the aim of which is to discover novel genes and mechanisms that contribute to heart, lung and blood disorders.Each exome was sequenced to a mean coverage of 116×, allowing detailed inferences about the population genomic patterns of both common variation and rare coding variation.We identifi ed more than 500,000 single nucleotide variations, the majority of which were novel and rare (76% of variants had a minor allele frequency of less than 0.1%), refl ecting the recent dramatic increase in the size of the human population.The unprecedented magnitude of this dataset allowed us to rigorously characterize the large variation in nucleotide diversity among genes (ranging from 0 to 1.32%), as well as the role of positive and purifying selection in shaping patterns of proteincoding variation and the diff erential signatures of population structure from rare and common variation.This dataset provides a framework for personal genomics and is an important resource that will allow inferences of broad importance to human evolution and health.
Journal of Medical Genetics
Journal: BMJ (1963)

Noonan syndrome is a genetic autosomal dominant disorder characterized by facial dysmorphy, short stature, delayed puberty and congenital heart defects.The first gene implicated in this syndrome is PTPN11, encoding protein tyrosine phosphatase SHP-2.Several studies worldwide have identified missense mutations in this gene in patients with Noonan syndrome.Our objective focused on mutations screening of PTPN11 on a Senegalese population with Noonan syndrome.Six patients clinically diagnosed with Noonan syndrome were included in this study.DNA was extracted from whole blood by phenol chloroform.Mutation screening was performed by bidirectional sequencing of amplified polymerase chain reaction (PCR) products of PTPN11 exons frequently mutated in Noonan syndrome.This study identified in two patients, a c.923A˃C mutation in exon 8, predicting Asn308Thr (N308T) on SHP-2 protein.This is the first time that this mutation is described in Noonan syndrome in Africa, while codon 308 was reported as a hot spot mutation site in other populations.Frequently reported amino acid substitutions were Asn308Asp and Asn308Ser.All these mutations affected the protein tyrosine phosphatase domain (PTP) of SHP-2 protein exerting a gain of function which would likely explain observed phenotypes in patients.
Transfusion-induced falciparum malaria
Authors: S. J. Seligman
Journal: JAMA (1971)

<h3>To the Editor.—</h3> The increased incidence of malaria in the United States is largely attributable to returning war veterans from South Vietnam. Transfusion-induced malaria has also increased. Transfusion-induced falciparum malaria observed in an anephric patient receiving long-term hemodialysis illustrates the possibility of transmission of falciparum malaria from an asymptomatic donor, with no history of malaria, who had last been in a malarious area one year prior to blood donation. <h3>Report of a Case.—</h3> A 34-year-old white man in renal failure had been receiving hemodialysis for five years. Bilateral nephrectomy had been performed three years previously for control of hypertension. On Nov 5, 1970, six days after his last monthly transfusion, fever, chills, malaise, and headache began. Another eight days later, the 48-hour periodicity of his temperature elevations was noted. A peripheral blood smear revealed ring forms of<i>Plasmodium falciparum</i>in less than 1% of the red blood cells (RBC) (Fig
Diabetes Death Rates Among Youths Aged ≤19 Years— United States, 1968–2009
Journal: JAMA (2012)

Although diabetes mellitus most often is diagnosed in adulthood, it remains one of the most common serious chronic diseases of childhood. Youths with diabetes are at risk for diabetes-related mortality because of acute complications that can result from the condition, including diabetic ketoacidosis and hypoglycemia. In the United States in 2010, an estimated 215,000 persons aged ≤ 19 years had diagnosed diabetes. Medical care for diabetes has improved considerably in recent decades, leading to improved survival rates. However, recent trends in diabetes death rates among youths aged <10 years and 10-19 years in the United States have not been reported. To assess these trends, CDC analyzed data from the National Vital Statistics System for deaths in the United States with diabetes listed as the underlying cause during 1968-2009. This report highlights the results of that analysis, which found that diabetes-related mortality decreased 61%, from an annual rate of 2.69 per million for the period 1968-1969 to a rate of 1.05 per million in 2008-2009. The percentage decrease was greater among youths aged <10 years (78%) than among youths aged 10-19 years (52%). These findings demonstrate improvements in diabetes mortality among youths but also indicate a need for continued improvement in diabetes diagnosis and care.
Miscellany.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal