tbuckley/cabot-search huggingface dataset:
Biliary atresia: Current concepts and research directions. Summary of a symposium
Authors: W Balistreri
Journal: Hepatology (1996)

Biliary atresia (BA) is the end result of a destructive, inflammatory process that affects intra- and extrahepatic bile ducts, leading to fibrosis and obliteration of the biliary tract with the development of biliary cirrhosis. It is the commonest cause of chronic cholestasis in infants and children, and therefore is the most frequent indication for liver transplantation in this age group. The disease occurs worldwide, affecting an estimated 1 in 8,000 to 12,000 live births. At present, there is no specific therapy for BA; however, sequential surgical therapy begins with creation of a hepatoportoenterostomy (HPE); in those with end-stage liver disease, liver transplantation is indicated. Since most candidates are young children of small size, there is a shortage of size-matched donors for liver transplantation. At present, an increased awareness to ensure early diagnosis and development of methods to prevent progressive fibrosis are needed. These considerations are dependent on detailed studies of the pathogenesis of BA. Recent studies have focused on normal and altered bile duct morphogenesis and the role of various factors (infectious or toxic agents and metabolic insults) in isolation or in combination with a genetic or immunologic susceptibility in the etiology of BA.
SPAIN
Authors: A. P. Fernandez
Journal: BMJ (1905)

Dr. Santini desires to alter this so as to allow only those who have obtained an Italian diploma to practise.As a pre- liminary he has succeeded in making the obtaining of this diploma far more difficult for foreign medical mnen.By the taw of 1859 graduates of a foreign University of the first tank were permitted to enter for the final examina- -tion, which, if they passed, entitled them to the diploma of M.D.By Dr. Santini's modification foreign graduates will be examined in one of the subjects of the second biennial period of the Italian medical curriculum -namely, physiology, pathological anatomy, general and epecial pathology, and materia medica, chosen by lot, and also in any of the subjects in which it may be considered that they have not been properly instructed at their own univer- sity.This modification renders it necessary for each Medical Faculty to examine into the course of studies pursued at the ,university whence the candidate comes, an undertaking which -permits of the greatest possible deliberation.Thus the Medical Faculty of the University of Rome has taken in one linstance over three years to examine into the value of an ,Oxford M.D. curriculum without coming to any decision.Dr. Santini has succeeded in uniting all the various Ordine ,dei Medici on this subject, and by skilfully utilizing it as a ,point d'appui, has almoat succeeded in welding together a politico-medical party under his leadership, which, although it owes its birth to a retrograde idea, may yet become an ,Instrument of the greatest use, and may even develop new political ideals of great consequence to thewell-being of the people.In the meanwhile it is by no means unlikely that he *will pass his measure in the near future for the exclusion of loreign medical practitioners from Italy.SPAIN.
Surgery of Childhood.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BRAIN HEMORRHAGE.
Authors: WILLIAM A. DICKEY
Journal: JAMA (1905)

functional disturbance of the glands, or whether there is actually some anatomic alteration, is not known.I have been entirely unable to obtain portions of the stomach from a fatal case of lead poisoning in order to determine this point, but the opportunity will cer¬ tainly arise in the course of time.The only conclusions that are at present justifiable appear to be:1.In a series of 12 cases of lead poisoning, or sus¬ pected lead poisoning, there was deficiency in the se¬ cretion of HCl in 10 of the chronic cases, and no de¬ ficiency in 2, one of which was doubtful and the other acute.2. This deficiency in the secretion of free HCl in the majority of cases is associated with an extreme re¬ duction in the percentage of peptic digestion, and with the presence of lactic acid.3. It is not justifiable at present to regard it as an indication for treatment, at least not until the effects of the ordinary treatment for achylia gastrica in cases of lead poisoning have been tested.
Effect of Rimonabant on Weight and Cardiometabolic Risk Factors—Reply
Authors: F. Xavier Pi-Sunyer
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
COMPARISON OF OUTCOMES IN PATIENTS UNDERGOING RENAL TRANSPLANTATION WITH IMPAIRED VERSUS NORMAL LEFT VENTRICULAR EJECTION FRACTION
Authors: Tigran Khachatryan, Deepika Narasimha, Haig Lafian, Mehron Deriss, David Chung, Carolyn Krystal, Antoine Sakr, Kenneth Jutzy, Anthony A. Hilliard, Amir Abdi Pour, Islam Abudayyeh, Liset Stoletniy
Journal: Journal of the American College of Cardiology (2018)
LRP10 in α-synucleinopathies
Authors: Demis A Kia, Marya S Sabir, Sarah Ahmed, Joanne Trinh, Sara Bandres-Ciga, Alastair J Noyce, Rauan Kaiyrzhanov, Ben Middlehurst, Demis A Kia, Manuela Tan, Henry Houlden, Huw R Morris, Helene Plun-Favreau, Peter Holmans, John Hardy, Daniah Trabzuni, Jose Bras, John Quinn, Kin Y Mok, Kerri J. Kinghorn, Kimberley Billingsley, Nicholas W Wood, Patrick Lewis, Sebastian Schreglmann, Rita Guerreiro, Ruth Lovering, Lea R'Bibo, Mie Rizig, Mina Ryten, Sebastian Guelfi, Valentina Escott-Price, Viorica Chelban, Thomas Foltynie, Nigel Williams, Alexis Brice, Fabrice Danjou, Suzanne Lesage, Jean-Christophe Corvol, Maria Martinez, Claudia Schulte, Kathrin Brockmann, Javier Simón-Sánchez, Peter Heutink, Patrizia Rizzu, Manu Sharma, Thomas Gasser, Aude Nicolas, Mark R Cookson, Sara Bandres-Ciga, Cornelis Blauwendraat, David W. Craig, Faraz Faghri, Raphael J. Gibbs, Dena G Hernandez, Kendall Van Keuren-Jensen, Joshua M. Shulman, Hirotaka Iwaki, Hampton L. Leonard, Mike A. Nalls, Laurie Robak, Steven Lubbe, Steven Finkbeiner, Niccolo E. Mencacci, Codrin Lungu, Andrew B Singleton, Sonja W. Scholz, Xylena Reed, Roy N. Alcalay, Ziv Gan-Or, Guy A. Rouleau, Jacobus J van Hilten, Johan Marinus, Astrid D. Adarmes-Gómez, Miquel Aguilar, Ignacio Alvarez, Victoria Alvarez, Francisco J. Barrero, Jesús A. Bergareche Yarza, Inmaculada Bernal-Bernal, Marta Blazquez, Marta Bonilla-Toribio, Juan A. Botía, María Teresa Boungiorno, Dolores Buiza-Rueda, Ana Cámara, Fátima Carrillo, Mario Carrión-Claro, Debora Cerdan, Jordi Clarimón, Monica Diez-Farien, Oriol Dols-Icardo, Jacinto Duarte, Raquel Duran, Francisco Escamilla-Sevilla, Mario Ezquerra, Cici Feliz, Manel Fernández, Rubén Fernández-Santiago, Ciara Garcia, Pedro García-Ruiz, Pilar Gómez-Garre, Maria Jose Gomez Heredia, Isabel Gonzalez-Aramburu, Ana Gorostidi Pagola, Janet Hoenicka, Jon Infante, Silvia Jesús, Adriano Jimenez-Escrig, Jaime Kulisevsky, Miguel A. Labrador-Espinosa, Jose L. Lopez-Sendon, Adolfo López de Munain Arregui, Daniel Macias, Irene Martínez Torres, Juan Marín, Maria Jose Marti, Juan Carlos Martínez- Castrillo, Carlota Méndez-del-Barrio, Manuel Menéndez González, Marina Mata, Adolfo Mínguez, Pablo Mir, Elisabet Mondragon Rezola, Esteban Muñoz, Javier Pagonabarraga, Pau Pastor, Francisco Perez Errazquin, Teresa Periñán-Tocino, Javier Ruiz-Martínez, Clara Ruz, Antonio Sanchez Rodriguez, María Sierra, Esther Suarez-Sanmartin, Cesar Tabernero, Juan Pablo Tartari, Cristina Tejera-Parrado, Eduard Tolosa, Francesc Valldeoriola, Laura Vargas-González, Lydia Vela, Francisco Vives, Alexander Zimprich, Lasse Pihlstrom, Mathias Toft, Sulev Koks, Pille Taba, Sharon Hassin-Baer
Journal: The Lancet Neurology (2018)
Constitutive Expression of Fas (Apo-1/CD95) Ligand on Multiple Myeloma Cells: A Potential Mechanism of Tumor-Induced Suppression of Immune Surveillance
Authors: Andreas Villunger, Alexander Egle, Ingrid Marschitz, Marion Kos, Günther Böck, Heinz Ludwig, Stephan Geley, Reinhard Kofler, Richard Greil
Journal: Blood (1997)
Chemical Structure, Reactivity, and Carcinogenicity of Halohydrocarbons
Authors: Benjamin L. Van Duuren
Journal: Environmental Health Perspectives (1977)

This review summarizes studies concerning the covalent binding of [14C]TCE to rat liver microsomal protein and exogenous DNA, in vitro, the enhancement of this binding by inducers of mixed-function oxidases, and inhibition of binding by inhibitors of these enzymes.Furthermore, recent studies on this type of binding in various strains of mice and rats of both sexes and using microsomal preparations from various organs are briefly reviewed.Other work reviewed here concerns the synthesis of TCE epoxide and its reaction with nucleophiles since it is believed that TCE epoxide is the activated carcinogenic inter- mediate of TCE.The utility of structural prognostication of carcinogenic activity and the importance of considering possible metabolic pathways for other chlorinated olefins is also discussed.
Recessive epidermolysis bullosa simplex associated with plectin mutations: infantile respiratory complications in two unrelated cases
Authors: J.E. MELLERIO, F.J.D. SMITH, J.R. McMILLAN, W.H.I. McLEAN, J.A. McGRATH, G.A.J. MORRISON, P. TIERNEY, D.M. ALBERT, G. WICHE, I.M. LEIGH, J.F. GEDDES, E.B. LANE, J. UITTO, R.A.J. EADY
Journal: British Journal of Dermatology (1997)
Herpes simplex virus encephalitis
Authors: S. U. Ho
Journal: JAMA (1982)

Herpesviruses capable of causing human neurological disease include herpes simplex, varicella-zoster, cytomegalovirus, and the Epstein-Barr (EB) virus. They are DNA viruses that contain a glycolipid envelope and replicate in the nucleus of the host cell. Members of this group share the property of causing primary (initial) infection and subsequent reactivation of latent infections. There are two serological strains of herpes simplex virus (HSV). The type 1 strains (HSV-1) cause almost all cases of herpes simplex encephalitis and meningitis in adults. Infections with the type 2 strains (HSV-2) occur as a vesicular eruption on genital mucosa, transmitted by sexual contact. Also associated with HSV-2 are disseminated disease of the newborn and occasional cases of viral meningitis in adults. Type 1 HSV is the single most important cause of fatal sporadic encephalitis in the United States and England. All age groups are affected, and there is no seasonal predominance of incidence. In
The Structure of the Atom.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Characterization of ASC-2 as an Anti-Atherogenic Transcriptional Coactivator of Liver X Receptors in Macrophages
Authors: Geun Hyang Kim, Keunhee Park, Seon-Yong Yeom, Kyung Jin Lee, Gukhan Kim, Jesang Ko, Dong-Kwon Rhee, Young Hoon Kim, Hye Kyung Lee, Hae Won Kim, Goo Taeg Oh, Ki-Up Lee, Jae W. Lee, Seung-Whan Kim
Journal: Endocrine Reviews (2009)

ABSTRACT Activating signal cointegrator-2 (ASC-2) functions as a transcriptional coactivator of many nuclear receptors and also plays important roles in the physiology of the liver and pancreas by interacting with liver X receptors (LXRs), which antagonize the development of atherosclerosis. This study was undertaken to establish the specific function of ASC-2 in macrophages and atherogenesis. Intriguingly, ASC-2 was more highly expressed in macrophages than in the liver and pancreas. To inhibit LXR-specific activity of ASC-2, we used DN2, which contains the C-terminal LXXLL motif of ASC-2 and thereby acts as an LXR-specific, dominant-negative mutant of ASC-2. In DN2-overexpressing transgenic (Tg) macrophages, cellular cholesterol content was higher and cholesterol efflux lower than in control macrophages. DN2 reduced LXR ligand-dependent increases in the levels of ABCA1, ABCG1, and apoE transcripts, as well as the activity of luciferase reporters driven by the LXR response elements (LXREs) of ABCA1, ABCG1, and apoE genes. These inhibitory effects of DN2 were reversed by overexpression of ASC-2. Chromatin immunoprecipitation analysis demonstrated that ASC-2 was recruited to the LXREs of the ABCA1, ABCG1, and apoE genes in a ligand-dependent manner and that DN2 interfered with the recruitment of ASC-2 to these LXREs. Furthermore, low density lipoprotein receptor (LDLR)-null mice receiving bone marrow transplantation from DN2-Tg mice showed accelerated atherogenesis when administered a high-fat diet. Taken together, these results indicate that suppression of the LXR-specific activity of ASC-2 results in both defective cholesterol metabolism in macrophages and accelerated atherogenesis, suggesting that ASC-2 is an anti-atherogenic coactivator of LXRs in macrophages.
Clinical Summaries
Journal: Circulation (2010)

Trial of 3 Therapeutic Strategies for Multivessel Coronary Artery DiseasePatients who are symptomatic because of coronary artery disease can be managed with medical therapy (MT), percutaneous coronary interventions (PCI), bypass surgery (CABG), or a combination of these strategies.It is unknown which treatment approach is best for specific patient subgroups.Here, we report 10-year follow-up of the second Medicine, Angioplasty, or Surgery Study (MASS II), a study that evaluated MT alone, PCI, or CABG among stable coronary patients with multivessel disease.No differences were observed in overall mortality in patients treated with CABG, PCI, or MT.Nevertheless, compared with CABG, MT was associated with a significantly higher incidence of cardiac death, subsequent myocardial infarction, and additional revascularization.Overall, compared with CABG, MT was associated with a 2.29-fold increased risk of combined events.Event rates for PCI patients were intermediate between MT and CABG.Indeed, by finding the lowest rate of further interventions in the CABG group, our results support a strategy of revascularization, and in particular CABG, in addition to MT for selected stable coronary patients with multivessel disease.See p 949. Long-Term Administration of Endothelin Receptor Antagonist Improves Coronary Endothelial Function in Patients With Early AtherosclerosisEndothelial dysfunction is considered critical in the initiation, progression, and complications of coronary artery disease and is independently associated with cardiovascular events.It is a reversible process that represents the functional expression of an individual's overall cardiovascular risk factor burden, and many therapies that restore endothelial function also decrease cardiovascular events.Coronary endothelial function is regulated by the balance of endothelium-derived vasodilator and vasoconstrictor factors such as endothelin-1.This study provides evidence that long-term ET A receptor antagonist administration improves coronary microvascular endothelial function in humans and supports a role for endogenous endothelin in the mechanism and potentially the treatment of coronary endothelial function in humans.See p 958.
Use of the Glycophorin A Human Mutation Assay to Study Workers Exposed to Styrene
Authors: Penelope J. E. Compton-Quintana, Ronald H. Jensen, William L. Bigbee, Stephen G. Grant, Richard G. Langlois, Martyn T. Smith, Stephen M. Rappaport
Journal: Environmental Health Perspectives (1993)

The glycophorin A (GPA) assay is a human mutation assay that is potentially useful for large epidemiological studies. The assay is rapid and requires a minimal amount of blood, which can be stored before analysis. The data presented here were collected from workers exposed to styrene in a boat manufacturing plant. This study was the first to apply the GPA assay to an occupationally exposed population. Subjects with a mean styrene exposure of 30 ppm had a higher frequency of GPA N phi variant cells than subjects with mean exposure of 1 ppm, but the subjects differed in respect to smoking and age distribution. Results indicate that the original 1-W-1 version of the assay may not be suitable for studies of small numbers of exposed subjects due to variability and artifacts. The newer BR6 version, however, has much lower variability and shows promise for use in the occupational setting.
Correction
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Simvastatin lowers plasma levels of C-reactive protein in hyperlipidemic patients Jonathan Isaacsohn, Michael H. Davidson, Donald Hunninghake, Helmut Schrott, Evan A. Stein, Yale B. Mitchel, Michele Mercuri, Michael E. Stepanavage. Metabolic and Atherosclerosis Research Center, Cincinnati, OH, Merck Research Laboratories, Rahway, NJ
Journal: Journal of the American College of Cardiology (2001)