tbuckley/cabot-search huggingface dataset:
Dosimetric Implications of Pulmonary Macrophage Clusters Observed within Lungs of Rats That Have Inhaled Enriched UO 2 Particles
Authors: Keith J. Morris, Caroline L. Barker, Angus L. Batchelor, Paul Khanna
Journal: Environmental Health Perspectives (1992)

Tlwenty-four wscher 34 rts were exposed to enriched uranium dioKide (UO0) aerosols to give a mean initial lung burden of291 ± 89 (SD) yg.Groups of rats were killed at 1, 7, 180, 360, 540, and 720 days post-inhalation (PI).Their lungs were fixed and inflated.Sections cut from all five lung lobes were used to prepare CR-39 neutron-induced 23.U fission frament autoradiographs.A single traverse across a CR-39 autoradiograph of a tissue section, from the left lung of all the rats, was made using a motorized microscopic stage.The traverse was divided into 10 fields.The track counts per field were used to test for homogeneity oftrack distribution and to assess if there was any tendency for tracks to be related to the peripheral region ofthe lung.FRUl raster scans across the entiretissue image were made on left lung autoradiographs from two animals kifled at each time point toassess the homogeneity offission fgment track dition ughout the entire section.There was no evidence of any temporal change in the proportion of tracks associated with the lung periphery.At all time points PI, the trck distribution was significantly nonhomogeneous, suggesting a nonuniform pattern of tissue irradiation from the 234U a particles.At time points from 180 to 720 days PI, large clusters of macrophages were observed in some of the sections taken from anl five lung lobes.The total number of macrophage clusters increased with time PI.These macrophage clusters produced many 235U fission fragment tracks within the CR-39 autoradiographs.The tracks within these macrophage clusters represented 04%4-4% ofthe entire trackcount for the section.The mean tU a-particle dose rate within these clusters was calculated to be 0.033 and 0.13 Gy/day, depending on the size of the cluster.This compares with the estimated dose rates averaged over the whole lung of Q021 Gy/day at 4 days PI and 0.0057 Gy/day at 720 days PI.
L'état réactionnel: Évolution du tissu lymphoïde en réaction.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TIPS and paracentesis for the treatment of refractory ascites (RA): Interims analysis of a randomized controlled trial A. Ochs, A.L. Gerbes*, K. Haag, J. Holl*, K. H. Hauenstein, T. Waggershausen*, M. Reiser*, G. Paumgartner*, H. E. Blum, M. R�ssle. Depts. of Medicine and Radiology Klinikum Gro?hadern, University of Munich* and MEdizinische und Radiologische Universit�tsklinik Freiburg, Germany
Journal: Hepatology (1995)
Antigen Activation and Impaired Fas-Induced Death-Inducing Signaling Complex (DISC) Formation in Large Granular Lymphocyte Leukemaia.
Authors: Jun Yang, P.K. Epling-Burrbette, Jeffrey S. Painter, Jian Zou, Fanqi Bai, Sheng Wei, Thomas P. Loughran
Journal: Blood (2007)
Dental jurisprudence.
Authors: George E. Hall
Journal: JAMA (1963)

After reading books on medical jurisprudence, which contain up to 840 pages, it is refreshing to pick up a volume on jurisprudence containing but 156 pages—including the index! This comparison is not intended to imply either that the books on medical jurisprudence are too long or that this book is too short. Neither implication would be correct. The present volume, although written primarily for dentists, is also applicable to physicians. In spite of his brevity, the author quite adequately discusses the most common causes of malpractice actions against dentists (failure to sterilize equipment, failure to x-ray, slipped instruments, foreign matter found in a patient's respiratory passages or jaw, administration of anesthetics, fractured jaws, fitting dentures, multiple extractions) and cites pertinent court decisions illustrating them. He points out the relationships which should obtain between dentists and patients, technicians, equipment salesmen, and other practitioners. In spite of its size, the book forcefully
Tardive dyskinesia and informed consent
Authors: A. M. Weinberg
Journal: JAMA (1986)

<h3>In Reply.—</h3> The letters by Drs Smith and Glass argue that patients have a right to participate in decisions about their resuscitation status. We agree. They also argue that such discussions are not anxiety provoking. We doubt it. Nevertheless, the real issue is when such discussions should be initiated. Should they take place at the time of admission to hospital? At the first office visit? In the emergency room? We believe that there is no universally correct answer to this question. Given that we cannot identify 100% of the patients who will subsequently suffer arrest, the demand that such discussions take place with each patient would mean that the issue of resuscitation should be raised with every patient on admission. We believe that this is unrealistic and possibly unwise policy. In clinical practice these discussions are initiated based on the specific circumstances of individual patients (ie, with patients who have
Barium sulfate granuloma of the rectum. A rare entity
Authors: G. F. Lull
Journal: JAMA (1971)

Barium sulfate granuloma of the rectum, a sequela of direct trauma to the rectal mucosa in the course of a barium sulfate enema examination, is a benign, usually asymptomatic lesion that must not be confused with carcinoma. This case confirms previous reports that barium sulfate crystals are inert and remain radiographically demonstrable in tissue for long periods of time. The paucity of reports of this lesion suggests that trauma to the rectal mucosa incident to barium sulfate enema studies is uncommon.
Diffuse Cystic Lung Disease. Part II
Authors: Nishant Gupta, Robert Vassallo, Kathryn A. Wikenheiser-Brokamp, Francis X. McCormack
Journal: American Journal of Respiratory and Critical Care Medicine (2015)

The diffuse cystic lung diseases have a broad differential diagnosis. A wide variety of pathophysiological processes spanning the spectrum from airway obstruction to lung remodeling can lead to multifocal cyst development in the lung. Although lymphangioleiomyomatosis and pulmonary Langerhans cell histiocytosis are perhaps more frequently seen in the clinic, disorders such as Birt-Hogg-Dubé syndrome, lymphocytic interstitial pneumonia, follicular bronchiolitis, and light-chain deposition disease are increasingly being recognized. Obtaining an accurate diagnosis can be challenging, and management approaches are highly disease dependent. Unique imaging features, genetic tests, serum studies, and clinical features provide invaluable clues that help clinicians distinguish among the various etiologies, but biopsy is often required for definitive diagnosis. In part II of this review, we present an overview of the diffuse cystic lung diseases caused by lymphoproliferative disorders, genetic mutations, or aberrant lung development and provide an approach to aid in their diagnosis and management.
Correction: Why patients were lost from follow-up at an urban diabetic clinic
Authors: W Allum
Journal: BMJ (1983)

asymmetrical distension with a tender tympanitic mass occupying the right lower quadrant.Bowel sounds were absent.Plain abdominal radiographs showed the features of acute caecal volvulus.At laparotomy a 180' anticlockwise rotation of the caecum was found with a gangrenous anterior wall.Diverticular disease of the colon was confirmed, and there was a paracolic abscess around the lower descending and upper sigmoid colon.Subtotal colectomy was carried out with a primary end to end ileorectal anastomosis.Uneventful recovery followed until 37 days post- operatively, when a small faecal fistula developed.This closed over the next 14 days, and she was discharged 55 days postoperatively.'Namba T, Brunner NG, Grob D. Myasthenia gravis in patients with thymoma, with particular reference to onset after thymectomy.
Commentaire de travail de C. Aumeran et al., pp. 895
Journal: Endoscopy (2010)

C. Aumeran, L. Poincloux, B. Souweine, F. Robin, H. Laurichesse, O. Baud, G. Bommelaer, O. Traoré. Eradication de Klebsiella Pneumoniae multirésistante après CPRE
Government Services
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Insulin Receptors
Authors: Bernard Deseuquois, Pedro Cuatrecasas
Journal: Annual Review of Medicine (1973)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease 2019 (COVID-19), emerged in China in December 2019 and quickly spread around the globe, killing more than 4 million people and causing a severe economic crisis. ...Read More
SPIROCHÆTA HEBDOMADIS, THE CAUSATIVE AGENT OF SEVEN DAY FEVER (NANUKAYAMI)
Authors: Yutaka Ido, Hiroshi Ito, Hidetsune Wani
Journal: The Journal of Experimental Medicine (1919)

1. Spirochata hebdomadis is always present in seven day fever and can be confirmed by animal experiments with guinea pigs of light weight. 2. The causative agent of this disease can also be found in film preparations of the blood of patients, though it is not present in large numbers. 3. Spirochæta hebdomadis is discharged in the urine of patients having seven day fever. The number of spirochetes in the urine is great during convalescence. 4. Seven day fever is a disease found not only in the Prefecture of Fukuoka, but in many other districts of Japan as well.
Oncogene Addiction
Authors: I. Bernard Weinstein, Andrew Joe
Journal: Cancer Research (2008)

Abstract Cancer cells contain multiple genetic and epigenetic abnormalities. Despite this complexity, their growth and survival can often be impaired by the inactivation of a single oncogene. This phenomenon, called “oncogene addiction,” provides a rationale for molecular targeted therapy. The efficacy of this strategy requires novel methods, including integrative genomics and systems biology, to identify the state of oncogene addiction (i.e., the “Achilles heel”) in specific cancers. Combination therapy may also be required to prevent the escape of cancers from a given state of oncogene addiction. [Cancer Res 2008;68(9):3077–80]
Cytomegalovirus Encephalitis
Authors: Jose R. Arribas
Journal: Annals of Internal Medicine (1996)

Purpose: To review the pathologic and clinical features of and establish the frequency of cytomegalovirus encephalitis in adults and to review the methods available for diagnosis and treatment. Data Source: MEDLINE search of all English-language articles from January 1965 to August 1995. Study Selection: Articles dealing with cytomegalovirus infection of the brain in adults. We also reviewed all unselected autopsies of these populations to establish the frequency of cytomegalovirus encephalitis in recipients of organ transplants and in patients infected with the human immunodeficiency virus (HIV). Data Extraction: Epidemiologic and pathologic characteristics, clinical manifestations, diagnostic methods, pathogenetic mechanisms, and use of anticytomegalovirus treatments. Data Synthesis: Of 676 patients receiving a diagnosis of cytomegalovirus encephalitis, 574 (85%) were infected with HIV, 81 (12%) had other causes of immunosuppression, and 21 (3%) were otherwise healthy. Cytomegalovirus encephalitis was confirmed during autopsy in 12% of HIV-infected patients and 2% of transplant recipients. The most common lesion was microglial nodule encephalitis, but the clinical findings corresponding to this pathologic entity are not well defined. In contrast, the pathologic entity of cytomegalovirus ventriculoencephalitis, found almost exclusively in patients with advanced HIV infection, has distinct clinical features that allow recognition even in patients with HIV encephalopathy. Polymerase chain reaction has been shown to be useful for diagnosis of cytomegalovirus encephalitis. Conclusions: Cytomegalovirus encephalitis is an important opportunistic infection in HIV-infected patients but is rarely recognized in other groups. Cytomegalovirus ventriculoencephalitis has emerged as a unique entity in patients with advanced HIV infection. Recent developments in diagnostic techniques allow early recognition and may make more aggressive approaches to therapy possible.
COLPOPERINEORRHAPHY AND THE STRUCTURES INVOLVED.
Authors: BYRON ROBINSON
Journal: JAMA (1898)

In 1887 Dr. Hadra of Texas contributed some valuable articles on the subject of perineorrhaphy. He suggested vivisection of the posterior vaginal wall for colporrhaphy, as is done in anterior colporrhaphy. Since 1880, the laborers in the field are legion. Gradually the operation of perineorrhaphy was modified from Paré, Baker-Brown, Dieffenbach, Langenbeck and Simon to Tait and Emmet. The modification consisted in denuding not only the perineal tears, but also denuding higher up in the posterior vaginal wall. Hildebrandt especially carried the denudation well up into the posterior vaginal wall. As regards suture material, Sims, Thomas, Emmet and others worked out the application of metallic wire to plastic labors on the perineum during the past thirty years. The modern tendency is to use silkworm gut as a non-absorbable suture. This may be left weeks in a wound, and acts as a splint in coapting the surfaces. It is easy to
Legacy
Authors: Kathryn P Celauro
Journal: Annals of Internal Medicine (2013)

On Being a DoctorJuly 2, 2013LegacyKathryn P. Celauro, MDKathryn P. Celauro, MDFrom Nashville, Tennessee.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-159-1-201307020-00014 Audio Reading - “Legacy” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Legacy," by K.P. Celauro. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail I did my grieving in the days following my father's diagnosis. Just 2 weeks after the birth of my first child, a son, and his only grandchild, I was in no place emotionally to begin a headlong dive into mourning, but that is exactly what happened. When he handed me his CT scan report—pancreatic mass, liver metastases, and lytic bone lesions—I knew that Dad had little time.I work as an obstetrician near the medical facility where Dad started treatment. He allowed me to go with him to the first appointment. Leaving bottles of pumped breast milk at home with ... Author, Article, and Disclosure InformationAffiliations: From Nashville, Tennessee.Current Author Address: Kathryn P. Celauro, MD; e-mail, [email protected]. PreviousarticleNextarticle Advertisement Audio Reading - “Legacy” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Legacy," by K.P. Celauro. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics July 2, 2013Volume 159, Issue 1Page: 70-71KeywordsBirthBoneBreast milkChemotherapyComputed axial tomographyEmotionsForecastingGene therapyGraduate medical educationInternetLiverMemoryMotivationMusclesNursesPancreatic cancerPatientsShouldersTouch ePublished: 2 July 2013 Issue Published: July 2, 2013 Copyright & PermissionsCopyright © 2013 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Asthma consensus is unconvincing to many
Authors: P. Cotton
Journal: JAMA (1993)

OFFICIALLY there is worldwide agreement on how to treat asthma. In the real world, researchers and clinicians seem to be gasping for consensus the way their patients do for air. General practitioners and many patients refuse to give anti-inflammatory drugs, especially inhaled glucocorticosteroids, the prominent place in their treatment regimen recommended time and again by randomized, controlled studies and consensus panels around the globe. The thousands of abstracts on asthma at this year's American Lung Association meeting in San Francisco, Calif, reflect both the interest and lack of understanding in this common disease, says Paul O'Byrne, MD, professor of medicine and head of respirology at McMaster University School of Medicine, Hamilton, Ontario. Wide disagreement on everything from the etiology and mechanisms of asthma to the best and most cost-effective therapy was aired at the meeting. <h3>Steroid Phobia</h3> With the asthma death rate in the United States doubling over the last
New health care research agency reflects interest in evaluating quality
Authors: C. Marwick
Journal: JAMA (1990)

RESEARCH ON HEALTH care policy has come of age and with this will come major changes in measuring and ensuring quality of care. A prime example: Congress has created the Agency for Health Care Policy and Research within the US Public Health Service. As a result of this new emphasis, "by the end of this century, no nation in the world will be as proficient as the United States in evaluating the quality of care. As a result, the American health care system will be unrivaled by the year 2000," predicts Uwe Reinhardt, PhD, Princeton (NJ) University. The new Agency for Health Care Policy and Research is charged with conducting and supporting research on health care services and delivery systems. It has three main activities: (1) research on outcomes; (2) technology assessment; and (3) development of practice guidelines. In the process, the agency will conduct demonstration projects (mostly through extramural
Poster Session 1: Fibrosis: Clinical and Translational
Journal: Hepatology (2014)

407Agroup compared to the D group.In liver, D-feeding tended to reduce Abcg5 and Abcg8 mRNA and increased mRNA expression of the xenobiotic receptors CAR and PXR target genes, including Cyp2B10, Cyp3a11, Mrp2, Mrp3, Mrp4, and Oatp1a4, compared to control mice.These data suggest that PXR and CAR might play central roles in xenobiotic sensing and detoxification after D-feeding.Compared to the D group, DE-feeding restored hepatic Abcg8 mRNA expression and enhanced hepatic mRNA expression of HMGCoAR, HMGCoAS, Cyp27a1, and the nuclear receptors PXR and FXR target genes, such as Cyp3a11, Oatp1a4, PXR, BAAT, BACS, and Bsep.These data suggest that ezetimibe might promote cholesterol and bile acid synthesis after DE-feeding, resulting in activation of the bile acid sensors FXR and PXR.In ileum, D-feeding induced mRNA expression of Cyp3a11 and ezetimibe reduced mRNA expression of LXRα, Abcg8, Mrp2, Mrp3, MTTP, and Ostα, compared to control mice.In conclusion, diosgenin induces cholestasis in mice as indicated by higher serum total bilirubin, ALP, and bile acid levels.Ezetimibe protects against diosgenin-induced cholestatic liver injury, possibly involving activation of bile acid receptors.
Giant ulcers of the transverse colon
Authors: V. S. Naiken
Journal: JAMA (1971)

<h3>To the Editor.—</h3> Giant ulcers of the colon are rare, and when present are sometimes associated with, or caused by, steroid medication.<sup>1</sup>In the case to be briefly reported, no specific etiological agent could be identified. As we have been unable to find any helpful information on discrete colonic ulcers from a recently published book on the pathology of the alimentary canal,<sup>2</sup>we wonder if your readers have encountered similar cases or have any views on the matter. <h3>Report of a Case.—</h3> A 72-year-old hypertensive woman, receiving hydrochlorothiazide medication for five years, was hospitalized in January 1971 with hoarseness, rectal bleeding, and anemia. Sigmoidoscopy revealed a small benign rectal ulcer which was biopsied. Because of continued bleeding, the rectum was again inspected and biopsy again showed acute and chronic nonspecific ulceration. A barium enema disclosed what was interpreted as a carcinoma of the transverse colon. A transverse colectomy
Prognostic implications of the e antigen of hepatitis B virus
Authors: O. Fay
Journal: JAMA (1977)

The e antigen HB<sub>e</sub>Ag and its antibody anti-HB have been said to be predictive of chronicity and resolution, respectively, in viral hepatitis. We found, as have others, a specific association with hepatitis B virus-induced disease. In addition, detectability of HB<sub>e</sub>Ag in the acute phase of type B hepatitis was followed by a sixfold higher incidence of chronic hepatitis. Unfortunately, the prediction was erroneous in 65% of positive cases and 6% of negative cases. In chronic hepatitis, HB<sub>e</sub>Ag did not necessarily disappear in advance of resolution, and its disappearance did not necessarily indicate resolution. Two patients with acute hepatitis progressing to chronicity were anti-HB<sub>e</sub>-positive in both phases, as were seven (5%) with chronic hepatitis. For individual patients, therefore, HB<sub>e</sub>Ag and anti-HB<sub>e</sub>are not prognostically useful indexes. (<i>JAMA</i>238:2501-2503,1977)