tbuckley/cabot-search huggingface dataset:
Adverse Outcomes Associated With Use of Proton Pump Inhibitors and Clopidogrel
Authors: Habib A. Dakik
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Identification of Hodgkin and Reed-Sternberg cell-specific genes by gene expression profiling
Authors: Ralf Küppers, Ulf Klein, Ines Schwering, Verena Distler, Andreas Bräuninger, Giorgio Cattoretti, Yuhai Tu, Gustavo A. Stolovitzky, Andrea Califano, Martin-Leo Hansmann, Riccardo Dalla-Favera
Journal: Journal of Clinical Investigation (2003)

Hodgkin lymphoma (HL) is a malignancy of unknown pathogenesis. The malignant Hodgkin and Reed/Sternberg (HRS) cells derive from germinal center B cells (or rarely, T cells) but have a heterogeneous and largely uncharacterized phenotype. Using microarrays, we compared the gene expression profile of four HL cell lines with profiles of the main B cell subsets and B cell non-HLs to find out whether HRS cells, despite their described heterogeneity, show a distinct gene expression, to study their relationship to other normal and malignant B cells, and to identify genes aberrantly or overexpressed by HRS cells. The HL lines indeed clustered as a distinct entity, irrespective of their B or T cell derivation, and their gene expression was most similar to that of EBV-transformed B cells and cell lines derived from diffuse large cell lymphomas showing features of in vitro–activated B cells. Twenty-seven genes, most of which were previously unknown to be expressed by HRS cells, showed aberrant expression specifically in these cells, e.g., the transcription factors GATA-3, ABF1, EAR3, and Nrf3. For five genes, expression in primary HRS cells was confirmed. The newly identified HL-specific genes may play important roles in the pathogenesis of HL, potentially represent novel diagnostic markers, and can be considered for therapeutic targeting.
A Confirmation
Authors: Jonathan Fink
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prevalence of Fruit and Vegetable Consumption and Physical Activity by Race/Ethnicity—United States, 2005
Journal: JAMA (2007)

Diets high in fruits and vegetables and participation in regular physical activity are associated with a lower risk for several chronic diseases and conditions. The National Cholesterol Education Program and the American Cancer Society both emphasize lifestyle modifications that include diet and physical activity to reduce disease risk. These are also two of the strategies implemented by states participating in CDC's Nutrition and Physical Activity Program to Prevent Obesity and Other Chronic Diseases. To examine the combined prevalence of 1) consumption of fruits and vegetables five or more times per day and 2) regular physical activity among U.S. adults by race/ethnicity, CDC analyzed self-reported data from the 2005 Behavioral Risk Factor Surveillance System (BRFSS). This report describes the results of that analysis, which indicated that the combined prevalence of these two behavioral strategies was higher among men of multiple/other races (16.5%) compared with non-Hispanic white men (12.6%). In addition, only 12.6% of non-Hispanic black women and 14.8% of Hispanic women, compared with 17.4% of non-Hispanic white women, engaged in these two behavioral strategies. These results underscore the need to promote diets high in fruits and vegetables and regular physical activity among all populations in the United States and among racial and ethnic minority communities in particular.
Book Review An Introduction to Clinical Perimetry . By H. M. Traquair, M.D., F.R.C.S. (Edin.). With a foreword by Norman M. Dott, M.B., Ch.B., F.R.C.S. (Edin.). Fourth edition, revised and enlarged. 8°, cloth, 332 pp., with 245 illustrations and 3 coloured plates. London: Henry Kimpton, 1942. $6.50.
Journal: New England Journal of Medicine (1944)
Use of Hospital Discharge Data to Monitor Uterine Rupture--Massachusetts, 1990-1997
Journal: JAMA (2000)

Uterine rupture (UR), a potentially life-threatening condition for both mother and infant, occurs in <0.1% of all pregnant women and <1% of women attempting vaginal birth after cesarean section (VBAC) (1-4). During 1990-1997, the proportion of vaginal deliveries among women who had previous cesarean sections (CS) in Massachusetts increased 50%, from 22.3% to 33.5% (5). Concern about a corresponding increase in UR prompted the Massachusetts Department of Public Health and CDC to initiate a state-wide investigation that included an assessment of the validity and reliability of International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) (6), codes in hospital discharge data to identify UR cases. This report summarizes the results of the investigation, which indicate that ICD-9-CM codes related to UR, designed before increased concern about UR, lack adequate specificity for UR surveillance and have not been applied consistently over time.
Guidelines for platelet transfusion
Authors: S. Murphy
Journal: JAMA (1988)

Thirty years ago platelet transfusions were not available. Thrombocytopenic bleeding led to morbidity and mortality in patients with aplastic anemia and hematologic malignancies. Now, platelet transfusions generally are as available as any physician wishes. This ready availability and the development of potent antibiotics have allowed hematologists and oncologists to employ increasingly aggressive chemotherapy and radiotherapy in the treatment of a wide variety of malignancies. This in turn has dramatically increased the size of the pool of thrombocytopenic candidates for platelet transfusion. Unfortunately, as this pool expands, the pool of physicians who cared for patients without having platelet transfusions available shrinks. Collectively, we do not remember who really needs a platelet transfusion and who does not. In this issue ofTHE JOURNAL, McCullough et al<sup>1</sup>estimate that our annual national expenditure for platelet transfusion therapy is approximately $100 million. We should ask how much of this money is well spent
Shalala Names Alternative Medicine Board
Journal: JNCI Journal of the National Cancer Institute (1994)

Shalala Names Alternative Medicine Board Get access JNCI: Journal of the National Cancer Institute, Volume 86, Issue 18, 21 September 1994, Pages 1383–1384, https://doi.org/10.1093/jnci/86.18.1383 Published: 21 September 1994
Caffeine Use During Pregnancy: How Much Is Safe?
Authors: Laura Fenster
Journal: JAMA (1993)

<h3>To the Editor.</h3> —The article by Mills et al<sup>1</sup>is one of the first prospective evaluations of the relationship of caffeine use and reproductive outcomes and, thus, is an important contribution to the field. However, we have concerns about the authors' conclusions. First, the results of this study are inconsistent with many of the findings previously reported. Nine of 12 studies representing a variety of populations and study designs found a relationship between maternal caffeine consumption and low birth weight or intrauterine growth retardation (IUGR), although the evidence for the relationship of caffeine and spontaneous abortion (SAB) is less consistent.<sup>2</sup>Both decreased birth weight and an increase in SAB have been reported in monkeys consuming caffeine in drinking water at concentrations within the range of human exposure.<sup>3</sup>There are a number of biologically plausible mechanisms for caffeine to adversely affect both of these end points, eg, vasoconstriction
Diabetic Neuropathy
Authors: Albert I. Winegrad
Journal: New England Journal of Medicine (1972)

Present evidence suggests that the diverse peripheral nervous syndromes associated with diabetes mellitus are not primarily the result of occlusive vascular disease. A possible exception is acute, painful, asymmetric neuropathy in older diabetic patients involving the ophthalmic, femoral, sciatic, or obturator nerve (or nerves) that may result from nerve infarcts. However, in biopsies of the radial and sural nerves from patients with the more common symmetrical distal polyneuropathy, the most conspicuous lesion is segmental demyelination, with evidence of repeated episodes of demyelination and remyelination, and abnormalities of the vasa nervorum are absent or infrequent.1 , 2 In these biopsies axonal loss and . . .
Evaluation of a Sedative-Hypnotic Agent
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Junior Hospital Staff Contract
Authors: F. B. V. Keane, M. R. Harrison, T. Papaioannou, A. T. Moore, A. G. Clarke, I. McClay, J. Harvey, K. E. Dunnett, J. R. Johnson, G. E. Jackson, M. A. Greenstone, B. S. Sekhawat, A. Wright, H. A. Bird, M. S. A. Kumar, B. Speculand, G. Sibley, K. R. Seath, J. P. Pollard, J. B. Jones, S. Hankey, M. J. Shanmugham, D. T. Sharpe, R. M. Gannaway, A. J. French, D. G. MacFarlane, N. J. Henderson, B. Fasher, A. F. Avery, S. S. H. Bailey, W. Hinton, G. J. Brown, B. M. Bryant, C. P. Chilton, M. R. Watts, J. A. West, M. R. Shihata, J. A. Thompson, M. H. Pelmore, R. M. Clark, W. House, R. E. Chisholm-Batten, A. Mousawi, R. Duffield, R. Rimmer, I. Davis, K. C. Vaughton
Journal: BMJ (1975)
A piece of my mind. An unexpected burden
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Epidemiological Studies for Regulatory Agencies
Authors: Vilma R. Hunt
Journal: Environmental Health Perspectives (1981)

In regulation of exposures to hazardous environmental agents, epidemiologic evidence is especially important in defining human risk estimates. The process of developing appropriate regulations is complex, however, and depends on many considerations beyond those established to a high degree of scientific certainty. Thus the needs of regulatory agencies are involved in the way epidemiologic data are developed and presented. To coordinate and review common problems associated with preventive and regulatory activities among the federal agencies concerned with regulation, an Interagency Regulatory Liaison Group (IRLG) was established in 1977. Because of difficulties encountered by these agencies or Congressional committees in evaluating epidemiologic evidence, a subcommittee of the IRLG has developed in draft form guidelines for human population studies to be used in public health decision-making. Although these guidelines have attracted much controversy, their aim is to present criteria for design and documentation of epidemiologic studies, without interfering with the initiative of investigators. Some aspects of the IRLG guidelines are discussed. The need for epidemiologic research in providing evidence for regulatory purposes is increasing, but such studies must be well done if they are to be useful.
Exercise, health, and medicine.
Authors: C C Harling
Journal: BMJ (1983)

that those who have no concern for the lives of innocent bystanders, do, to a great degree, forfeit the right to their own lives.The ethical practice of medicine is compatible with life- with all forms of life.We cannot condemn out of hand all doctors who live in dictatorships, etc. Nor should we condemn all people living in politically less fortunate countries to go without medical care.I do not like the tactics of the African National Congress or those of the South African police, nor do I agree with Professor De Klerk or Mr Bennun.But I am not prepared to condemn any of them, certainly not without a lot more evidence and a detailed knowledge of the circumstances.Overall, the people of South Africa
Reply to Urmila Dhakad and Bhupendra Pal Singh's Letter to the Editor re: Dean A. Tripp, J. Curtis Nickel, Jennifer Wong, et al. Mapping of Pain Phenotypes in Female Patients with Bladder Pain Syndrome/Interstitial Cystitis and Controls. Eur Urol. In press. http://dx.doi.org/10.1016/j.eururo.2012.05.023
Authors: Dean A. Tripp
Journal: European Urology (2012)
Maintaining standards of education while expanding physician production
Authors: J. C. Rose
Journal: JAMA (1970)

I will consider standards of education as determined by the attitudes and convictions of the faculty of an established school. When confronted with an increase in student enrollment, what are the questions we ask, the problems we foresee, and the alternative modifications in programs from which we can choose? What questions can we answer; what problems can we solve; what doubts remain? <h3>Should We Increase Enrollments?</h3> In our school, 14 of 15 department chairmen considered an increase in the size of the first-year class of a hypothetical 80% or so magnitude as "vital" or "highly desirable" (one refused to answer!). Few members of the faculty have been heard to deny the existence of a national health manpower shortage or the high priority that must be assigned to expanding enrollments. These few have directed their questions to whether the increased numbers will alleviate health care problems where they are most acute,
Future Leaders Recognized
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nitric oxide-producing CD11b+Ly-6G(Gr-1)+CD31(ER-MP12)+cells in the spleen of cyclophosphamide–treated mice: implications for T-cell responses in immunosuppressed mice
Authors: Iñigo Angulo, Federico Gómez de las Heras, José F. Garcı́a-Bustos, Domingo Gargallo, M. Angeles Muñoz-Fernández, Manuel Fresno
Journal: Blood (2000)
Chloramphenicol Today
Authors: William Kitto
Journal: JAMA (1975)

AN OCCASIONAL reassessment of one's tactics in the management of any illness should be a salutary exercise. Rather frequent reassessment is wise for infectious disease management, for here the interaction of armament and agent tends to undergo modification with elapsing time. Heavy use of an antibiotic by a patient population will reduce the available reproductive gene pool for agents sensitive to that antibiotic within the treated population, allowing hardier species or strains to occupy the available<i>lebensraum</i>. Reports of encounters with strains of<i>Haemophilus influenzae</i>showing resistance to ampicillin have been appearing for several years.<sup>1-4</sup>The variance of this pathogen and the implication of shifting dominance of strains denies validity to the premise that the ultimate drug of choice for<i>H influenzae</i>meningitis can be established by a long-term, double-blind trial.<sup>4</sup>These considerations modify the risk-benefit ratio of chloramphenicol and move it to serious contention for primary drug
Quality improvement campaign led to higher surveillance rate for hepatocellular carcinoma in primary care clinic
Authors: Kanit Bunnag, Amarat Kongsompong, Wit Jeamwijitkul, Worayon Chuerboonchai, Chutatip Charoenthanawut, Pongpan Boonmeeseeprasert, Nattawit Seetalarom, Amnart Chaiprasert, Sakkarin Chirapongsathorn
Journal: Journal of Hepatology (2020)
Leads from the MMWR. Progress toward the 1990 objectives for improved nutrition
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Update: AIDS Among Women—United States, 1994
Journal: JAMA (1995)

In 1993, human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) was the fourth leading cause of death among women aged 25-44 years in the United States (1); in addition, the incidence of AIDS is increasing more rapidly among women than men (2). Women with AIDS reported in 1994 represented 13% of the cumulative total of 58,448 cases among women. This report presents characteristics of women and men reported with AIDS in 1994, summarizes trends in cases reported during 1985-1994, and describes findings of an HIV seroprevalence survey among childbearing women during 1989-1993.
Seroprevalence and risk factors for HTLV-I/II infection among female prostitutes in the United States
Authors: R. F. Khabbaz
Journal: JAMA (1990)

We tested 1305 female prostitutes from eight areas of the United States for antibodies to human T-cell lymphotropic virus type I/II. Overall, 6.7% were human T-cell lymphotropic virus type I/II seropositive (with antibodies to both<i>gag</i>and<i>env</i>gene products). The seroprevalence rates ranged from 0% in southern Nevada to 25.4% in Newark, NJ. Human T-cell lymphotropic virus type I/II seropositivity was independently associated with race (odds ratio, 4.68), intravenous drug use (odds ratio, 2.94), hepatitis B seropositivity (odds ratio, 2.87), recruitment in Newark (odds ratio, 2.34), and more years of sexual activity (odds ratio, 1.08 per year of sexual activity). Groups with high rates included blacks, Hispanics, and American Indians, and the rates in these groups were significantly higher than among whites and Asian Americans for women both with and without a history of intravenous drug use. Among intravenous drug users, the only other independent associations were more years of sexual activity and recruitment in Newark; and in non-intravenous drug users, hepatitis B seropositivity. These data show that human T-cell lymphotropic virus type I/II infection is present among female prostitutes in some areas of the United States. Further studies are needed to evaluate patterns of transmission and long-term health effects. (<i>JAMA</i>. 1990;263:60-64)