tbuckley/cabot-search huggingface dataset:
Twenty-third Annual Report oe the State Board of Health of Massachusetts.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
In vitro Germination Characteristics of Maize Pollen to Detect Biological Activity of Environmental Pollutants
Authors: Paul L. Pfahler
Journal: Environmental Health Perspectives (1981)

In vitro pollen germination was examined as a method to determine the mutagenic and physiological effects of environmental pollutants on higher organisms. Results were presented indicating that mutations could be distinguished by their in vitro germination characteristics if sporophytes homozygous for the mutated allele were tested. The addition of agents directly into the in vitro medium was shown to be an effective method to assess their physiological effects. The exposure of pollen grains during the in vitro germination process to ultraviolet radiation in the B range (280-320 nm) was found to produce little or no change in the germination or ruptured percentage but a sharp decrease in pollen tube growth after 1 hr. In vitro pollen germination appears to be a valuable method to examine the mutation types and physiological effects produced by a broad range of environmental pollutants. In fact, since in vitro germination is related to reproduction and gene transmission, the biological activity of these agents on in vitro germination should be tested routinely to determine their possible effects on food production and gene frequency changes in future generations.
Boards of Examiners in the Basic Sciences
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A randomised placebo controlled trial of pegylated interferon in active ulcerative colitis
Authors: H Tilg
Journal: Gut (2003)

Pilot studies of interferon alpha (IFN-alpha) suggest a high remission rate in the treatment of active ulcerative colitis. We evaluated the safety of pegylated interferon alpha (PegIFN) and its role in induction of remission in patients with active ulcerative colitis, in a multicentre placebo controlled trial.Sixty patients with a clinical activity score (CAI) of >6 were randomised to receive placebo (n=20), PegIFN 0.5 microg/kg (n=19), or PegIFN 1.0 microg/kg body weight (n=21) once weekly (PegIntron; Schering-Plough, USA) over 12 weeks. Patients receiving 5-aminosalicylates, steroids, and/or azathioprine in stable dosages were included.Serious adverse events were seen in none of the placebo patients, in 3/19 patients in the PegIFN 0.5 microg/kg group (hospitalisation due to disease flare up n=3), and in 3/21 in the PegIFN 1.0 microg/kg group (hospitalisation due to disease flare up n=1; thrombosis n=1; grand mal seizure n=1). Otherwise, we observed only minor IFN-alpha side effects. Clinical remission rates at week 12 (CAI < or =4) were 7/20 (35%) in the placebo, 9/19 (47%) in the PegIFN 0.5 microg/kg group, and 7/21 (33%) in the PegIFN 1.0 microg/kg group (NS). Early withdrawal from the study was observed in 11/20 placebo patients, in 6/19 in the PegIFN 0.5 microg/kg group, and in 10/21 in the PegIFN 1.0 microg/kg group, mainly due to lack of efficacy. The higher PegIFN dose was associated with a significant decrease in levels of C reactive protein (p=0.003, day 0 v 85).PegIFN is safe but not effective, at the dosages used, in patients with ulcerative colitis.
Tuberculous meningitis in a puerperal woman
Authors: R. D. Brandstetter
Journal: JAMA (1980)

ALTHOUGH tuberculous meningitis (TBM) rarely complicates pregnancy and seldom occurs in puerperal women,<sup>1</sup>the prognosis for such patients has been surprisingly poor. Despite a younger patient population and the availability of effective antituberculous therapy, between 32% and 68% of pregnant or puerperal women with TBM have died.<sup>1,2</sup>We report a case of TBM in a previously healthy woman whose signs and symptoms developed immediately after delivery and were initially attributed to postpartum depression and a puerperal-acquired bacterial infection. Although unusual, this case illustrates another clinical setting in which reactivated tuberculosis may first be manifested. <h3>Report of a Case</h3> After 39 weeks of pregnancy, a previously healthy, 24-year-old woman spontaneously gave birth to a healthy infant. One day later, low-grade fever developed. During the next three days, she became withdrawn and noncommunicative and was thought to be depressed. Fever persisted despite oral cephalexin monohydrate therapy; on the fourth hospital
Sella turcica und Konstitution: Versuch einer Sellagrössen- und Formdeutung innerhalb konstitutionsmedizinischer Gefügue
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Exome Sequencing Identifies Recurring FLT3 N676K Mutations in Core Binding Factor Leukemia
Authors: Sabrina Opatz, Harald Polzer, Tobias Herold, Nikola P Konstandin, Bianka Ksienzyk, Alexander Graf, Stefan Krebs, Helmut Blum, Karl Peter Hopfner, Purvi M. Kakadia, Stephanie Schneider, Annika Dufour, Jan Braess, Michael Heuser, Wolfgang Hiddemann, Karsten Spiekermann, Stefan K Bohlander, Philipp A Greif
Journal: Blood (2012)
Pulmonary phycomycosis without obvious predisposing factors
Authors: N. B. Record
Journal: JAMA (1976)

THE PHYCOMYCETES (<i>Mucor, Absidia</i>, and<i>Rhizopus</i>) are common saprophytes. Infection with these fungi occurs primarily in patients with severe underlying illness, especially leukemia, lymphoma, and uncontrolled diabetes mellitus.<sup>1</sup>Our case is note-worthy because<i>Rhizopus</i>pneumonia occurred without obvious predisposing factors. <h3>Report of a Case</h3> A 66-year-old man was hospitalized because of cavitary pneumonia. Two months previously, bilateral knee surgery was performed, with cephalothin sodium prophylaxis. Two weeks before admission, fever, chills, pleurisy, and cough with yellow, blood-tinged sputum developed. One week before admission, a chest x-ray film disclosed left lower lobe infiltrate, and penicillin V potassium was given orally. Despite clearing of the initial infiltrate, symptoms worsened, and the chest x-ray film showed a new, left upper lobe infiltrate with central cavitation (Figure). Results of a physical examination on admission were unremarkable except for bibasilar and left axillary rales, decreased knee mobility, and moderate dyspnea. Multichannel (SMA-12) chemistry profiles
ORIGINAL INVESTIGATIONS ON THE NATURAL HISTORY, (SYMPTOMS AND PATHOLOGY) OF YELLOW FEVER. 1854-1894.
Authors: JOSEPH JONES
Journal: JAMA (1894)

(<i>Continued from page 948</i>.) Chapter II. The following cases will serve to illustrate the effects of a preceding attack of malarial paroxysmal fever, upon the progress of the symptoms and pathology of yellow fever: PATHOLOGY OF YELLOW FEVER RELATIONS TO MALARIAL FEVER. <i>Case 17</i>.—Remittent fever followed by yellow fever; patient reduced in strength and anemic before the attack of yellow fever; fatal issue; liver presented the marks of both yellow fever and malarial fever. Mark Curtis; age 22; native of Germany. Entered Charity Hospital, Oct. 18,1873. Patient states that on October 3 he was seized with vomiting followed by high fever; the vomiting and fever returned every alternate day, until his entrance into the hospital. Previous to this time had been exposed to the malaria of the swamps; came to New Orleans on October 3, 1873. Has resided in America five years, and in Louisiana since October 1 of the
British ponder 'presumed consent' for organ harvesting
Authors: C. Marwick
Journal: JAMA (1984)

The British government also is mounting a new publicity campaign to try to increase public awareness of the need for organs for transplantation, and to encourage the carrying of signed organ-donor cards. However, the British have decided to postpone consideration of a proposal that would permit organs to be transplanted from anyone who, during life, does not specifically deny permission. Nonetheless, the government has agreed to reconsider the proposal "in a positive manner" next year. Under the present system, popularly known as "opting in," organs cannot be gathered from suitable cadavers without permission from the next of kin. The exception is if the person previously had completed an organ card indicating that in the event of death those organs can be collected. However, surveys, such as a recent one by the British Kidney Patients Association, have shown that while two thirds of those questioned were willing to donate their kidneys
Coexistence of palmoplantar lichen planus and lupus erythematosus with response to treatment using acitretin
Authors: E. M. G. J. JONG, P. C. M. KERKHOF
Journal: British Journal of Dermatology (1996)

Lichen planus and lupus erythematosus may occur as an overlap syndrome.Here we report the clinical characteristics of a 49-year-old man with palmoplantar lichen planus and lupus erythematosus.He showed a remarkable clinical response to treatm ent with acitretin, which resulted in prolonged remission of the disorder.Lichen planus and lupus erythem atosus m ay coexist 1 C
Oral Pathology
Authors: Paul E. Boyle
Journal: JAMA (1961)

Certain texts tower above all others. Their appearance in the medical literature often marks the gathering together into a single volume of contributions hitherto published in many journals and texts. Thoma's<i>Oral Pathology</i>, which first appeared in 1941, summarized the then available knowledge in this field and demonstrated that diseases of the face, jaws, teeth, and oral mucosa had developed a literature worthy of comparison with that of diseases of the eye or other specific anatomical areas. Professor Thoma was eminently qualified for this undertaking. His background included the general practice of dentistry, the teaching of prosthetic dentistry in the dental school and anatomy in the medical school, authorship of one of the early and outstanding texts on oral roentgenology followed by editorship of a leading dental journal, and then a distinguished career as an oral surgeon. When the first edition appeared he was the Charles A. Brackett Professor of
Cystathioninuria
Authors: George W. Frimpter, Asher Haymovitz, Melvin Horwith
Journal: New England Journal of Medicine (1963)

A MAN with cystathioninuria, as well as physical and mental abnormalities, is described below. We believe that this patient represents the second reported case of this entity. Five of his relatives also had elevated cystathionine excretion but were otherwise normal.Cystathioninuria was first described in 1959 by Harris, Penrose and Thomas1 in a sixty-four-year-old female imbecile who had bilateral talipes calcaneovalgus. Two of the patient's relatives also had cystathioninuria of a lesser degree but were otherwise normal.Case ReportA 44-year-old pocketbook maker was admitted to the hospital because of progressive enlargement of the hands and inability to work. He . . .
Marriages
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Book Review Dizionario di medicina per medici e famiglie . By Dott. Giulio Casalini. F°, cloth. Vol. 1, 868 pp., with 1550 illustrations and 24 color plates; Vol. 2, 917 pp., with 1912 illustrations and 35 color plates. Torino, Italy: Corso Taffaello, 1939. Lire 300.
Journal: New England Journal of Medicine (1941)
Brentuximab Vedotin with Chemotherapy for Stage 3/4 Classical Hodgkin Lymphoma (cHL): 4-Year Update of the Echelon-1 Study
Authors: Nancy L. Bartlett, David J. Straus, Monika Dlugosz-Danecka, Sergey Alekseev, Arpad Illes, Ewa Lech-Maranda, Tatyana A. Feldman, Piotr Smolewski, Kerry J Savage, Jan Walewski, Radhakrishnan Ramchandren, Pier Luigi Zinzani, Martin Hutchings, Joseph M. Connors, John Radford, Javier Munoz, Won-Seog Kim, Ranjana H Advani, Stephen M Ansell, Anas Younes, Andrea Gallamini, Harry Miao, Rachael Liu, Keenan Fenton, Andres Forero-Torres, Marco Picardi
Journal: Blood (2019)
BioPrep. A premedical program for rural high school students
Authors: H. J. Knopke
Journal: JAMA (1986)

To address physician maldistribution in Alabama and the Southeast region, The University of Alabama established the Biomedical Sciences Preparation Program (BioPrep) in five rural high schools. Its purpose is to help rural, disadvantaged high school students develop academically and socially so that they will be motivated and able to enroll in and progress successfully through college, specifically in pre-health professional curricula. It aims to develop their desire to return eventually to rural areas of Alabama as professionals. Project students are compared with two control groups. Performance on the American College Testing Program college entrance examination revealed significantly higher achievement by the project students. The project students also chose professional careers earlier and more frequently than matched high school students not receiving this special program, but similar to medical students and premedical students. The implications of the project for increasing the size of the rural, disadvantaged student applicant pool are discussed. (<i>JAMA</i>1986;256:2548-2551)
Eltrombopag For The Management Of Thrombocytopenia Associated With Tyrosine Kinase Therapy In Patients With Chronic Myeloid Leukemia and Myelofibrosis
Authors: Gautam Borthakur, Srdan Verstovsek, Elias Jabbour, Jairo Matthews, Tapan M. Kadia, Naval Daver, Hagop M. Kantarjian, Jorge Cortes
Journal: Blood (2013)
Puncture of the gallbladder during percutaneous transhepatic cholangiograhy
Authors: C. J. DeMasi
Journal: JAMA (1967)

Seven cases of unintentional puncture of the gallbladder occurred during percutaneous transhepatic cholangiography. Adequate visualization of the biliary tree was obtained in each case. Biliary leakage developed in one patient who had complete obstruction due to carcinoma of the pancreas. As more percutaneous transhepatic cholangiography is performed, we may expect more instances of inadvertent puncture of the gallbladder to appear. Suggestions are offered that may help reduce the complications and yet allow the procedure to be performed even in instances where puncture of the gallbladder seems inevitable.
Calcification in soft tissues
Authors: V. L. Stewart
Journal: JAMA (1983)

THE PRESENCE of calcification in soft tissues and its radiological appearance may aid in the diagnosis and treatment of certain systemic disorders. When the soft-tissue calcification occurs with an elevated serum calcium-phosphorus ion product, it is termed<i>metastatic calcification</i>. In these patients, amorphous calcium phosphate and calcium hydroxyapatite crystals are deposited in multiple locations. The appearance of metastatic calcification is typical but not disease specific. Microscopically, the deposition of calcium salts may be observed in the lung, stomach, and kidney. Vascular calcification is also present, as are large, periarticular soft-tissue masses. When soft-tissue calcification occurs in altered, necrotic, or dead tissue in patients whose serum calcium and phosphorus levels are normal, it is called<i>dystrophic calcification</i>, which is influenced by multiple physiological factors. These include serum calcium, phosphorus and alkaline phosphatase,<sub>p</sub>H of the tissue, vitamin D, hormonal balance, blood supply, and injury of soft tissues.<sup>1</sup> <h3>Metastatic Calcification</h3>
Isolated proximal left anterior descending coronary artery stenosis: Long-term clinical outcome after percutaneous interventions Irene Bossi, Catherine Klersy, Christian Jordan, Bibi Fatemeh Hayerizadeh, Fadi Bou Aoun, Jean Claude Laborde, Bruno Bernard Cassagneau, Jean Fajadet, Jean Marco. Clinique Pasteur - UCI, Toulouse, France
Journal: Journal of the American College of Cardiology (2001)
Gynecology
Authors: Joe V. Meigs
Journal: JAMA (1962)

The first sentence in one of the forewards, "Every once in a while a new idea in writing a book on an old subject is born," expresses exactly the feelings of this reviewer. This volume presents a new type of gynecology. Omitted, and correctly so, are descriptions of various operations, as gynecologic surgery is so well illustrated in Parson's and Ulfelder's<i>An Atlas of Pelvic Operations</i>. Diseases of the female, from infancy to old age, are carefully described, pathologically oriented, and their treatments suggested. The comprehensive discussions answer many troublesome female problems. So often monographs on gynecology do not contain the solutions to problems arising in the newborn and in old age. Segregating the decades in the book was a wise choice, for, obviously, certain ages are more prone to particular diseases than others. Perhaps this method has led to a few repetitions, but they are deliberate and fall into
<i>Circulation</i> : Clinical Summaries
Journal: Circulation (2012)

Cardiovascular disease and heart failure are highly prevalent among those who undergo cardiac surgery, contributing to hemodynamic stress that may be poorly characterized by clinical history.Consequently, natriuretic peptide biomarkers that better characterize this underlying physiology have become well established in the diagnosis and management of patients with heart failure.In this study, 1139 adults who underwent cardiac surgery were evaluated from 6 centers to establish whether preoperative brain natriuretic peptide (BNP) levels predict postoperative acute kidney injury (AKI; defined by Acute Kidney Injury Network definitions; at least mild AKI was a Ͼ0.3-mg/dL [26 mol/L] or 50% rise in creatinine, and severe AKI was either a doubling of creatinine or the requirement of acute renal replacement therapy).In this high-risk cohort, AKI was common (at least mild AKI, nϭ407 [36%]; severe AKI, nϭ58 [5.1%]).After adjustment for different preoperative characteristics, preoperative BNP was a strong and independent predictor of mild and severe AKI.Compared with the lowest BNP quintile, the highest quintile had significantly higher risk of at least mild AKI (risk ratio, 1.87) and severe AKI (risk ratio, 3.17).After adjustment for clinical predictors, the addition of BNP improved the area under the curve to predict at least mild AKI and severe AKI.Compared with clinical parameters alone, BNP also improved risk prediction of AKI cases into lower and higher risk.Preoperative BNP level is associated with postoperative AKI in high-risk patients undergoing cardiac surgery and may be a valuable component of future efforts to improve preoperative risk stratification among surgical candidates.See p 1347.
Spirometry in a medical clinic
Authors: S. W. Rosner
Journal: JAMA (1965)

Discriminant function analysis was performed on several measurements from the forced expiratory spirogram obtained in a group of first-visit patients at a medical clinic. The analysis provided a discriminant function score which is a predictive index of the presence or absence of respiratory dysfunction. The forced vital capacity as a percentage of the predicted vital capacity and the forced expiratory volume at two seconds as a percentage of the forced vital capacity were the prime discriminants. The spirometric score value was a helpful diagnostic aid to the physician in detecting a ventilation abnormality.
Outcomes of Patients (pts) with Myelodysplatic Syndrome (MDS) and Chronic Myelomonocytic Leukemia (CMML) Post Clofarabine Failure
Authors: Hady Ghanem, Guillermo Garcia Manero, Stefan Faderl, Koichi Takahashi, Farhad Ravandi, Jorge E. Cortes, Susan O'Brien, Naval G. Daver, Lakshmikanth Katragadda, Naveen Pemmaraju, Sherry A. Pierce, Alfonso Quintás-Cardama, Tapan M. Kadia, Hagop M. Kantarjian, Elias J. Jabbour
Journal: Blood (2012)