tbuckley/cabot-search huggingface dataset:
Worldwide Survey on the Methods, Efficacy, and Safety of Catheter Ablation for Human Atrial Fibrillation
Authors: Riccardo Cappato, Hugh Calkins, Shih-Ann Chen, Wyn Davies, Yoshito Iesaka, Jonathan Kalman, You-Ho Kim, George Klein, Douglas Packer, Allan Skanes
Journal: Circulation (2005)

Background— The purpose of this study was to conduct a worldwide survey investigating the methods, efficacy, and safety of catheter ablation (CA) of atrial fibrillation (AF). Methods and Results— A detailed questionnaire was sent to 777 centers worldwide. Data relevant to the study purpose were collected from 181 centers, of which 100 had ongoing programs on CA of AF between 1995 and 2002. The number of patients undergoing this procedure increased from 18 in 1995 to 5050 in 2002. The median number of procedures per center was 37.5 (range, 1 to 600). Paroxysmal AF, persistent AF, and permanent AF were the indicated arrhythmias in 100.0%, 53.0%, and 20.0% of responding centers, respectively. The most commonly used techniques were right atrial compartmentalization between 1995 and 1997, ablation of the triggering focus in 1998 and 1999, and electrical disconnection of multiple pulmonary veins between 2000 and 2002. Of 8745 patients completing the CA protocol in 90 centers, of whom 2389 (27.3%) required &gt;1 procedure, 4550 (52.0%; range among centers, 14.5% to 76.5%) became asymptomatic without drugs and another 2094 (23.9%; range among centers, 8.8% to 50.3%) became asymptomatic in the presence of formerly ineffective antiarrhythmic drugs over an 11.6±7.7-month follow-up period. At least 1 major complication was reported in 524 patients (6.0%). Conclusions— The findings of this survey provide a picture of the variable and evolving methods, efficacy, and safety of CA for AF as practiced in a large number of centers worldwide and may serve as a guide to clinicians considering therapeutic options in patients suffering from this arrhythmia.
The Effects of PCB Exposure and Fish Consumption on Endogenous Hormones
Authors: Victoria Persky, Mary Turyk, Henry A. Anderson, Lawrence P. Hanrahan, Claire Falk, Dyan N. Steenport, Robert Chatterton, Sally Freels, None The Great Lakes Consortium
Journal: Environmental Health Perspectives (2001)

Previous studies have suggested that exposure to polychlorinated biphenyls (PCBs) may alter thyroid function, but data on effects of PCB exposure on other endogenous hormones has been lacking. The current study is ancillary to a larger investigation of the effects of Great Lakes fish consumption on PCBs and reproductive function. In the current study we examine associations of PCBs, 1,1-bis (4-chlorophenyl)-2,2-dichloroethene (DDE), and fish consumption with thyroid and steroid hormones in 178 men and PCBs, DDE, and fish consumption with thyroid hormones in 51 women from the original study. Serum PCB level and consumption of Great Lakes fish are associated with significantly lower levels of thyroxine (T(4)) and free thyroxine index (FTI) in women and with significantly lower levels of T(4) in men. Fish consumption, but not PCB level, is significantly and inversely associated with triiodothyronine (T(3)) in men. Results for thyroid-stimulating hormone (TSH) are inconsistent. Among men, there are significant inverse associations of both PCB and fish consumption with sex hormone-binding globulin (SHBG)-bound testosterone, but no association with SHBG or free testosterone. There are no significant overall associations of PCB, DDE, or fish consumption with estrone sulfate, follicle-stimulating hormone, luteinizing hormone, or dehydroepiandrosterone sulfate. The results of this study are consistent with previous studies showing effects of fish consumption and PCB exposure on thyroid hormones and suggest that PCBs may also decrease steroid binding to SHBG. Elucidation of specific mechanisms must await future investigations.
British Journal of Ophthalmology, London
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bronchial hyperreactivity in cystic fibrosis and asthma Mitchell, I. Corey, M., Woenne, R., Krastins, I.R.B., and Levison, H.: J. Pediatr. 93:744, 1978
Authors: Murray Albertbrooklyn, Bernard Siegel Brooklyn, N Friedman, David Stein, Spring Valley
Journal: Journal of Allergy and Clinical Immunology (1979)
Water Arsenic Exposure and Children’s Intellectual Function in Araihazar, Bangladesh
Authors: Gail A. Wasserman, Xinhua Liu, Faruque Parvez, Habibul Ahsan, Pam Factor-Litvak, Alexander van Geen, Vesna Slavkovich, Nancy J. Lolacono, Zhongqi Cheng, Iftikhar Hussain, Hassina Momotaj, Joseph H. Graziano
Journal: Environmental Health Perspectives (2004)

Exposure to arsenic has long been known to have neurologic consequences in adults, but to date there are no well-controlled studies in children. We report results of a cross-sectional investigation of intellectual function in 201 children 10 years of age whose parents participate in our ongoing prospective cohort study examining health effects of As exposure in 12,000 residents of Araihazar, Bangladesh. Water As and manganese concentrations of tube wells at each child's home were obtained by surveying all wells in the study region. Children and mothers came to our field clinic, where children received a medical examination in which weight, height, and head circumference were measured. Children's intellectual function on tests drawn from the Wechsler Intelligence Scale for Children, version III, was assessed by summing weighted items across domains to create Verbal, Performance, and Full-Scale raw scores. Children provided urine specimens for measuring urinary As and creatinine and were asked to provide blood samples for measuring blood lead and hemoglobin concentrations. Exposure to As from drinking water was associated with reduced intellectual function after adjustment for sociodemographic covariates and water Mn. Water As was associated with reduced intellectual function, in a dose–response manner, such that children with water As levels > 50 μg/L achieved significantly lower Performance and Full-Scale scores than did children with water As levels < 5.5 μg/L. The association was generally stronger for well-water As than for urinary As.
Reduced fracture of the forearm in a child
Authors: O. Aufranc
Journal: JAMA (1965)

Dr. Kirby vonKessler: Shortly after finishing a large picnic lunch, an 8-year-old boy fell from a fence and injured his left wrist. One hour later he arrived at the emergency ward of the Massachusetts General Hospital. Motion and sensation in his hand were normal in spite of an obvious deformity of the distal forearm. The radial pulse was easily palpable. The skin over the deformity was intact. X-ray films showed fractures of the distal third of both the radius and ulna (Fig 1) with posterior and lateral displacement of the distal fracture fragments. There was approximately 1 cm of overriding of the fracture fragments. Dr. Aufranc: Dr. Arthur Pappas will discuss this fracture of both bones of the forearm in a child. Dr. Arthur Pappas: In the overall evaluation of a displaced fracture, there are three important factors to consider: the patient's age and cooperation, the anatomical location of the
Many questions, fewer answers, about pot
Authors: J. Elliott
Journal: JAMA (1980)

In the emotionally volatile area of marijuana research, a verdict for or against America's favorite recreational drug is still forthcoming. The data, coming mostly from animal studies or anecdotal evidence, are neither definitive nor complete. Moreover, almost all research focuses on heavy, long-term use of marijuana. Nevertheless, a number of physicians and medical researchers are starting to agree that marijuana represents a health hazard in various ways and that its growing use, particularly among the young, is a serious matter for concern. Currently 43 million Americans, roughly 30% of the adult population, are known to have tried marijuana at least once. Sixteen million use it regularly and, most alarming, there are 4 million regular users under age 17. Compared with the heyday of marijuana research in the 60s, research into the biologic effects of the drug today is a mere shadow of its previous self. This stems in part from
Incidence of Bleeding with Clot Retention in Suprapubic Prostatectomy
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Resuscitation of Drowned Children
Authors: J. R. Gibbs
Journal: BMJ (1971)

Save the Children Fund. Mental Health ResearchWith inflation at its present rate, says the Annual Report of the Mental Health Re- search Fund, each year 20% more money must be raised just to continue the support of a constant volume of research.Projects of high scientific merit are being turned down for lack of funds.Among research currenly receiving support is a study of the biochemistry of schizophrenia at Edinburgh; investigation of infant behaviour at Cam- bridge; and work on psychogenic amenorr- hoea.
GOVERNMENT CONTROL OF VACCINE VIRUS.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A phase II trial of trastuzumab combined with irinotecan in patients with advanced HER2-positive chemo-refractory gastric cancer: OGSG1203 (HERBIS-5).
Authors: Naotoshi Sugimoto, Daisuke Sakai, Junji Kawada, Ryohei Kawabata, Kazuhiro Nishikawa, Tomono Kawase, Yoshio Oka, Takeshi Shimizu, Junichi Nishijima, Hiroko Hasegawa, Shunji Endo, Yutaka Isozaki, Yutaka Kimura, Jin Matsuyama, Yukinori Kurokawa, Toshio Shimokawa, Kazumasa Fujitani, Taroh Satoh
Journal: Journal of Clinical Oncology (2016)

e15546 Background: Irinotecan is a key drug in second- or further-line chemotherapy for patients with advanced gastric cancer. Continuous administration of trastuzumab beyond first progression is expected to contribute to the benefit of chemotherapy for HER2-positive gastric cancer. We assessed the efficacy and safety of combination chemotherapy with trastuzumab and irinotecan in Japanese patients with advanced HER2-positive chemo-refractory gastric cancer. Methods: Intravenous infusion of irinotecan every 2 weeks at a dose of 150 mg/m2; intravenous infusion of trastuzumab at a dose of 8 mg/kg on day 1 of the first cycle, followed by 6 mg/kg every 3 weeks. Administration of irinotecan and trastuzumab were repeated in independent schedules. The primary endpoint was disease control rate (DCR). The secondary endpoints were adverse events (AEs), response rate (RR), time-to-treatment failure (TTF), progression-free survival (PFS) , overall survival (OS), and RR stratified by prior trastuzumab use. This study was conducted by the Osaka Gastrointestinal Cancer Chemotherapy Study Group (OGSG). Results: From October 2012 to Augst 2014, 30 patients were enrolled and one patient withdrew before study treatment. Accordingly, 29 patients were assessable for efficacy and safety. The DCR was 65.5% [95% C.I. 45.7 - 82.1%], and the RR was 20.7% [95% C.I. 8.0 - 39.7%]. The median PFS and OS were 3.7 and 7.5 months, respectively. The major grade 3/4 AEs were neutropenia (24%); anemia (24%); leucopenia (21%); anorexia (11%); fatigue (14%); hypoalbuminemia (24%); and hypokalemia (14%). One death (NOS) was considered to be related to the study. Treatment courses and relative dose intensity of each drugs were 6times (range: 1-23), 91.1 % (52.9-101.4) in irinotecan, and 5 times (1-17), 100.0% (61.3-102.9) in trastuzumab, respectively. Conclusions: The results of combination trastuzumab with irinotecan showed feasible and promising efficacy against advanced HER2-positive chemo-refractory gastric cancer. These findings indicated that trastuzumab continuation use might be beneficial. Clinical trial information: 000008626.
DEGENERACY OF PITCAIRN ISLANDERS.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
One-Stage Penectomy and Phalloplasty for Epithelioid Sarcoma of the Penis in an Adolescent: Part 2
Authors: Piet B. Hoebeke, Sylvie Rottey, Nathalie Van Heddeghem, Geert Villeirs, Patrick Pauwels, Wim Schrauwen, Peter Ceulemans, Stanislas Monstrey
Journal: European Urology (2006)
Peptide YY (PYY) Gene Polymorphisms in the 3′-Untranslated Region and Proximal Promoter Regions Regulate Cellular Gene Expression and PYY Secretion and Metabolic Syndrome Traits in Vivo
Authors: Pei-an Betty Shih, Lei Wang, Stephane Chiron, Gen Wen, Caroline Nievergelt, Manjula Mahata, Srikrishna Khandrika, Fangwen Rao, Maple M. Fung, Sushil K. Mahata, Bruce A. Hamilton, Daniel T. O'Connor
Journal: Endocrine Reviews (2009)

Obesity is a heritable trait that contributes to hypertension and subsequent cardiorenal disease risk; thus, the investigation of genetic variation that predisposes individuals to obesity is an important goal. Circulating peptide YY (PYY) is known for its appetite and energy expenditure-regulating properties; linkage and association studies have suggested that PYY genetic variation contributes to susceptibility for obesity, rendering PYY an attractive candidate for study of disease risk. To explore whether common genetic variation at the human PYY locus influences plasma PYY or metabolic traits, we systematically resequenced the gene for polymorphism discovery and then genotyped common single-nucleotide polymorphisms across the locus in an extensively phenotyped twin sample to determine associations. Finally, we experimentally validated the marker-on-trait associations using PYY 3′-untranslated region (UTR)/reporter and promoter/reporter analyses in neuroendocrine cells. Four common genetic variants were discovered across the locus, and three were typed in phenotyped twins. Plasma PYY was highly heritable (P < 0.0001), and genetic pleiotropy was noted between plasma PYY and body mass index (BMI) (P = 0.03). A PYY haplotype extending from the proximal promoter (A-23G, rs2070592) to the 3′-UTR (C+1134A, rs162431) predicted not only plasma PYY (P = 0.009) but also other metabolic syndrome traits. Functional studies with transfected luciferase reporters confirmed regulatory roles in altering gene expression for both 3′-UTR C+1134A (P < 0.001) and promoter A-23G (P = 0.0016). Functional genetic variation at the PYY locus influences multiple heritable metabolic syndrome traits, likely conferring susceptibility to obesity and subsequent cardiorenal disease.
The Harveian Oration Delivered before the Royal College of Physicians
Authors: G. Rolleston
Journal: BMJ (1873)

I PASS from this reflection to an exposition of the claims which have been put forward on behalf of Walter Warner, the editor in i63t of Harriott's Algebra, to the discovery of the circulation of the blood; and I do this by a natural transition, Walter WVarner having been a man in whose mind, all his mathematics notwithstanding, the idola in question greatly abounded.Warner's claims are alluded to by Dr. Willis in a note to his excellent Life of Harvey (see p.
Society Proceedings.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Family Practice
Authors: Robert E. Rakel
Journal: JAMA (1984)

It has been 15 years since the discipline of family practice was formally established. During this time a large body of literature devoted to primary health care has developed. A recent analysis of this literature has shown a steady increase in the number of articles that report the results of clinical research.<sup>1</sup>Most studies in family practice have focused on improving the provision of primary health care services, but there is also a special emphasis on the family and the effect of its close personal relationships on health and disease. Many of the developments of the past year are of importance not only to the family physician but to all physicians involved in primary health care. Foremost among these are advances in the areas of depression, hypertension, cancer detection, smoking cessation, and health care provision, especially the use of computers. Significant advances have been made in the diagnosis and
Incorrect Follow-up Period
Journal: JAMA Internal Medicine (2014)

Jeff C. Huffman, MD; Carol A. Mastromauro, LICSW; Scott R. Beach, MD; Christopher M. Celano, MD; Christina M. DuBois, BA; Brian C. Healy, PhD; Laura Suarez, MD; Bruce L. Rollman, MD; James L. Januzzi, MD
More on the GUSTO Trial
Authors: Kerry L. Lee
Journal: Annals of Internal Medicine (1994)

Letters15 November 1994More on the GUSTO TrialKerry L. Lee, Eric J. Topol, and Robert M. CaliffKerry L. LeeSearch for more papers by this author, Eric J. TopolSearch for more papers by this author, and Robert M. CaliffSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-121-10-199411150-00035 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Before our article was published [1], the GUSTO data were updated to reflect the most current and complete information available from the trial. The updated rates of coronary bypass surgery were 9.0% for accelerated tPA and 8.3% for streptokinase, rather than 9.5% and 8.5%, respectively. We regret that Ridker and colleagues were not provided with this latest information before its publication. However, even with the rates that Ridker and colleagues had available to them, their statement that “the actual difference in rates of bypass surgery was larger than any reported mortality difference in the trial” [2] was inaccurate. ...References1. Lee KL, Califf RM, Simes J, Van de Werf F, Topol EJ, for the GUSTO Investigators. Holding GUSTO up to the light. Ann Intern Med. 1994; 120:876-81. Google Scholar2. Ridker PM, O'Donnell CJ, Marder VJ, Hennekens CH. A response to “holding GUSTO up to the light.” Ann Intern Med. 1994; 120:882-5. Google Scholar3. Lee KL, Califf RM, Topol EJ. The last word on GUSTO, for now (Letter). Ann Intern Med. 1994; 120:970. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 November 1994Volume 121, Issue 10Page: 818-820KeywordsCoronary arteriesDrug administrationDrugsEmotionsMortalitySurgeryTissue plasminogen activator ePublished: 15 August 2000 Issue Published: 15 November 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...