tbuckley/cabot-search huggingface dataset:
Are Continuing Studies of Metabolic Control and Microvascular Complications in Insulin-Dependent Diabetes Mellitus Justified?
Journal: New England Journal of Medicine (1988)

The role of intensive therapy with the goal of achieving normal or nearly normal glycemia in patients with insulin-dependent diabetes mellitus has been actively debated.1 2 3 4 The crux of this debate is whether intensive therapy for diabetes can prevent or ameliorate the vascular complications that accompany the disorder. Retinopathy, nephropathy, and neuropathy occur in the majority of patients after they have had diabetes for variable periods. Besides metabolic control, environmental, genetic, and other factors, such as hypertension, have been proposed as risk factors for the development of complications. Although several recent reviews4 , 5 have considered the risks and putative benefits of intensive . . .
Mortality Among Patients with Mental Disease
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Positive troponin-I predicts early and late mortality after percutaneous coronary intervention Andrea S. Abizaid, Roxana Mehran, George Dangas, Shmuel Fuchs, Alexandre Abizaid, Alexandra J. Lansky, Ran Kornowski, Ron Waksman, Augusto D. Pichard, Lowell F. Satler, Gregg W. Stone, Martin B. Leon. Cardiovascular Research Foundation, New York, NY, Washington Hospital Center, Washington, DC
Journal: Journal of the American College of Cardiology (2001)
More Snakes
Authors: Claude A. Frazier
Journal: JAMA (1985)

<h3>To the Editor.—</h3> In the article entitled "One Snake or Two?"<sup>1</sup>it was said that "the snake is an appropriate symbol for the healing art" and that the symbol came from Greek mythology. The Greek mythology explains the origin of the snake as the staff of Aesculapius. I think that it is time to rethink and change the symbol of a physician from a snake to a healing hand. Satan comes to be identified with the serpent because of the story of the fall in Genesis 3. In the Bible, it is the serpent (Satan) who is the<i>cause of illness and pain</i>(Luke 13:16; Acts 10:38; 2 Corinthians 12:7). In Revelations 12:9, Satan, the serpent, is the deceiver of all mankind (2 Corinthians 11:31). In the New Testament, Satan becomes the tempter, the seducer, the leader astray of men. This power of evil is Satan. Satan, the serpent,
Abstract 19003: Extracellular ATP Induces Vascular Inflammation and Atherosclerosis via P2Y2 in Mice
Authors: Peter Stachon, Serjosha Geis, Adrian Heidenreich, Natalie Hoppe, Bianca Dufner, Marco Idzko, Andreas Zirlik
Journal: Circulation (2015)

Introduction: A solid body of evidence supports a role of extracellular ATP and ist P2-receptors in innate and adaptive immunity. It promotes inflammation as a danger signal in various chronic inflammatory diseases. Hypothesis: We hypothesize contribution of extracellular ATP and its receptor P2Y2 in vascular inflammation and atherosclerosis.Methods: Leukocyte rolling and adhesion after stimulation with ATP was determined with intravitalmicroscopy in P2Y2-competent and P2Y2-deficient mice. Migration was analyzed with peritonitis model. To test the role of extracellular ATP in atherosclerosis, ATP or saline as control was injected intraperitoneally three times a week in LDLR-/- mice consuming high cholesterol diet (HCD). Furthermore, P2Y2-competent or P2Y2-deficient mice consumed a HCD for 16 weeks. Atherosclerosis was determined with immunhistochemistry and lesional expression of inflammatory molecules was measured with realtime PCR. Results: Extracellular ATP induced leukocyte rolling, adhesion, and migration as assessed by intravital microscopy and in sterile peritonitis. Atherosclerosis significantly increased after 16 weeks in ATP-treated mice (n=13; control group 0.26mm2; ATP group 0.33mm2, p=0.01). To gain into the role of ATP-receptor P2Y2 in ATP induced leukocyte recruitment, ATP was administered systemically in P2Y2-deficient or -competent mice. In P2Y2-deficient mice the ATP induced leukocyte adhesion was significantly reduced. P2Y2 expression in atherosclerosis was measured by real-time PCR and immunohistochemistry and demonstrates an increased expression s mainly due to influx of P2Y2-expressing macrophages. To investigate the functional role of P2Y2 in atherogenesis, P2Y2-deficient LDLR-/- mice consumed HCD. After 16 weeks P2Y2-deficient mice showed significantly reduced atherosclerotic lesions with decreased macrophages compared to P2Y2-competent mice (n=11; aortic arch: control group 0.25mm2; P2Y2-deficient 0.14mm2, p=0.04). Mechanistically,atherosclerotic lesions from P2Y2-deficient mice expressed less lesional VCAM-1 and ICAM-1 RNA . Conclusion: We show for the first time that extracellular ATP induces vascular inflammation and atherosclerosis via activation of P2Y2.
Ethnic Labels in Medical Writing
Authors: J. R. E.
Journal: Annals of Internal Medicine (1969)

Editorials1 May 1969Ethnic Labels in Medical WritingJ. R. E., E. J. H.J. R. E.Search for more papers by this author, E. J. H.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-70-5-1041 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn a letter to the Editor published in this issue (p. 1050) the writer has objected both to the "racial identification of patients chiefly of Afro-American heritage" in the ANNALS and to our non-capitalization of the word negro. Because we sympathize strongly with the need to abolish racial discrimination and to reduce racial tensions, we have given much thought to these problems in medical writing, and we wish to state our editorial position.The first—and major—issue raised by Dr. Jenkins in this letter is whether ethnic descriptions ("racial tags") have any place in medical writing today. Is there any medical...Reference1. MCKUSICK VA: The ethnic distribution of disease in the United States (editorial). J. Chronic Dis. 20: 115, 1967. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1969Volume 70, Issue 5Page: 1041-1043KeywordsRacial and ethnic discrimination ePublished: 1 December 2008 Issue Published: 1 May 1969 PDF downloadLoading ...
A SECOND ATTACK OF MENINGITIS AFTER AN INTERVAL OF EIGHTEEN MONTHS
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SHOCK
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Transplacental transfer of influenza virus
Authors: D. H. Yawn
Journal: JAMA (1971)

Transplacental passage of virus occurred in a fatal case of influenza during the last trimester of pregnancy. The influenza virus (A2/Hong Kong/8/68) was identified in numerous extrapulmonary maternal tissues, amniotic fluid, and fetal heart. The maternal extrapulmonary tissues, fetal tissues, and placenta were free of any morphological abnormality which could be attributed to virus infection.
THE CAUSES OF SOME RAPID CHANGES IN BODY WEIGHT
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Archives of Dermatology, Chicago
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pathogenesis and treatment of varicoceles
Journal: BMJ (2004)

They should stimulate debate on the impact of pharmacogenomics on the clinical environment and, conversely, on the effect of clinical factors on the development and implementation of pharmacogenomics.Other criteria and examples may well emerge in the course of such a discussion, and the clinical validity, utility, and uptake of these strategies may change along with advances in technology or revisions to how health professionals (particularly doctors and pharmacists) are trained.Pharmacogenomics and related genomic advances are clearly placing a unique lens on the multiple actors participating in the development, regulation, and prescription of drugs, as well as the complex interactions within our health systems.Finally, the ethical, legal, social, economic, and regulatory implications of such a framework require further investigation, including considerations of equity, distributive justice, and the particular opportunities and challenges presented by various health systems and their organisation.
Neuroimmunology
Authors: Barry G.W. Arnason
Journal: New England Journal of Medicine (1987)

ON July 6, 1885, Joseph Meister, age nine, was brought by his mother to Louis Pasteur. The day before, he had been bitten 14 times by a rabid dog. Pasteur boldly treated the boy with a rabies-prophylaxis technique that he had been studying in dogs. Pasteur knew that spinal-cord tissue from rabbits with rabies lost virulence when it was desiccated. Beginning with cord tissue dried for 14 days, he gave Meister 12 injections over 10 days. Each day he gave fresher material; the final preparation had been in the desiccator for only one day. Meister survived. Rabbits injected with the . . .
CENTENARIANISM.
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
On the physical death of Jesus Christ
Authors: William Edwards, Wesley Gabel, Mdiv Floyd
Journal: JAMA (1986)

Jesus of Nazareth underwent Jewish and Roman trials, was flogged, and was sentenced to death by crucifixion.The scourging produced deep stripelike lacerations and appreciable blood loss, and it probably set the stage for hypovolemic shock, as evidenced by the fact that Jesus was too weakened to carry the crossbar (patibulum) to Golgotha.At the site of crucifixion, his wrists were nailed to the patibulum and, after the patibulum was lifted onto the upright post (stipes), his feet were nailed to the stipes.The major pathophysiologic effect of crucifixion was an interference with normal respirations.Accordingly death resulted primarily from hypovolemic shock and exhaustion asphyxia.Jesus' death was ensured by the thrust of a soldier's spear into his side.Modern medical interpretation of the historical evidence indicate that Jesus was dead when taken down from the cross.
Abstract 1908: Assessment of Coronary Segment Inflammation With Combined 18-Fluorodeoxyglucose Positron Emission Tomography and 64-slice Multidetector Computed Tomography.
Authors: Ian S Rogers, Amparo L Figueroa, Khurram Nasir, David Vermylen, Ricardo C Cury, Udo Hoffmann, Alan J Fischman, Thomas J Brady, Ahmed Tawakol
Journal: Circulation (2007)

Background : It has been well demonstrated that inflammation is strongly associated with ruptured plaques. Invasive angiographic studies have shown that vulnerable plaques tend to be clustered proximally in the coronary arteries. We tested the hypotheses that patients with ACS have a higher overall level of inflammation in their proximal coronary vessels compared to patients with stable coronary disease and that a gradient of inflammatory activity is seen within the coronary vasculature. Methods : Twenty-five patients (mean age 57.9 ± 9.8 years, 72% male) who underwent coronary angiography for chest pain were studied. Ten patients underwent PCI for ACS, 5 underwent PCI for chronic stable angina; and 10 with previously placed stents underwent diagnostic cath but did not require additional PCI. 64-slice MDCT angiography was performed (Siemens Sensation) followed by PET imaging (Siemens ECAT HR+) with 13mCi 18-FDG. PET imaging was done 3 hours after FDG injection. Myocardial uptake of FDG was minimized by a dietary intervention and beta blockade. Images were coregistered, SUVs were obtained at the locations of interest, and target to background ratios (T/B) were calculated. Results : Inflammation, measured as FDG activity (T/B), in the proximal coronary segments was significantly greater in patients presenting with ACS than with stable coronary disease (2.31 ± 0.62 vs. 1.84 ± 0.53, p = 0.0004). Similarly, aortic root inflammation was significantly greater in ACS patients presenting with ACS than in patients not presenting with ACS (3.61 ± 1.27 vs 2.52 ± 0.68, p = 0.028). A strong correlation was also observed between aortic root and proximal coronary inflammation in all patients (r = 0.76). Finally, a gradient of glycolytic activity (likely due to inflammation) was observed, as the left main T/B were significantly greater than the proximal vessels (2.38 ± 0.59 vs 1.77 ± 0.40, p &lt; 0.001) in all patients. Conclusion: This preliminary investigation demonstrates that metabolic activity - a surrogate for inflammation - is higher in patients with ACS and that a gradient of inflammatory activity is seen within the coronary vasculature. With further advances in methodology and technology, coronary PET imaging may prove useful for assessment of risk and response to therapy.
Issue Information
Journal: Medicinal Research Reviews (2020)

The journal publishes timely critical reviews of topics related to medicinal research, broadly defined, to which the authors have made significant contributions.Appropriate topics include, but are not limited to, the underlying pathophysiology of important diseases and disease vectors; therapeutic approaches to the treatment of various diseases; the properties of molecular targets for therapeutic agents; important new methodologies facilitating the search for therapies; genomics and proteomics; structure-activity correlations of drug series; the development of new imaging and diagnostic tools; drug metabolism; drug delivery; and chemical, pharmacological, pharmacokinetic, pharmacodynamic, and clinical characteristics of important drugs.Articles are mainly solicited by the editors; however, voluntary contributions are also encouraged.In the latter case, potential authors are asked to contact the Editor-in-Chief with an outline before beginning to write in order to avoid duplication of effort and to ensure suitability of the topic and the level of coverage.
219P Relationship among PDL1, androgen receptor (AR) and tumour infiltrating lymphocytes (TILs) in early triple negative breast cancer
Authors: L.F. Sánchez-Cousido, E. Honrado Franco, Ó. Sanz Guadarrama, L. López González, A. García-Palomo, M. López Flores, M. Rojas Piedra, B. Távara Silva, I. Delgado Sillero, C. Castañón López, P. Diz Taín, Á. Rodríguez Sánchez, B. Nieto Mangudo, A. López-González
Journal: Annals of Oncology (2020)
RECENT INVESTIGATIONS BEARING ON INFECTIOUS DISEASES OF UNKNOWN ETIOLOGY.
Authors: LUDVIG HEKTOEN
Journal: JAMA (1903)

There is a number of transmissible diseases, both human and animal, some of them exquisitely contagious, the causes of which are still unknown, notwithstanding the most careful search. Of the human diseases belonging to this group I would mention especially scarlet fever, measles, chicken-pox, yellow fever, typhus fever and hydrophobia. Smallpox and vaccinia may also be left here for the present. Of the animal diseases of this group the most important are foot and mouth diseases, peripneumonia, bovine pest, sheep-pox (clavelée), chicken-typhus or chicken-pest, "horse sickness" and epithelioma contagiosum of fowls. The "mosaic disease" of the tobacco plant ("Mosaik oder Fleckenkrankheit des Tabaks") may be given as an example of a contagious plant disease of unknown etiology. <h3>THE INFECTIOUS NATURE OF THE DISEASES DISCUSSED.</h3> In discussing the probable nature of diseases of this kind perhaps the first question to arise will be, "What evidence is there that they are caused
Jailhouse Blues
Authors: Joseph E. Paris
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal