tbuckley/cabot-search huggingface dataset:
Elevated Tumor Necrosis Factor-α and Interleukin-6 in Myocardium and Serum of Malfunctioning Donor Hearts
Authors: Emma J. Birks, Paul B. J. Burton, Virginia Owen, Antony J. Mullen, Diane Hunt, Nicholas R. Banner, Paul J. R. Barton, Magdi H. Yacoub
Journal: Circulation (2000)

Background —Myocardial dysfunction is a common and important problem in donor hearts. The mechanisms responsible remain unclear. We have studied the cytokines tumor necrosis factor (TNF)-α and interleukin-6 (IL-6) in the myocardium and serum from donors with myocardial dysfunction (unused donors) and compared them with donors with good ventricular function (used donors) and patients with advanced heart failure (HF). Methods and Results —Clinical details and ventricular function were assessed in 46 donors (31 used, 15 unused). Real-time reverse transcription–polymerase chain reaction, Western blotting, and immunocytochemistry were performed on myocardium and immunoassays on serum. TNF-α mRNA was 1.6-fold higher in unused than in used donors ( P &lt;0.005) and 1.74-fold higher than in 36 patients with HF. IL-6 mRNA was 2.4-fold higher in unused than in used donors ( P &lt;0.0001) and 4.67-fold higher than in HF ( P &lt;0.0001). Western blotting showed higher TNF-α in unused (218.3±6.4, n=4 versus 187.3±5.4, n=3 OD units) than used donors ( P &lt;0.05). TNF-α expression was localized to cardiac myocytes. Serum TNF-α was higher in unused (8.72±1.3 pg/mL, n=13) than in used (6.12±0.8 pg/mL, n=25, P &lt;0.05) donors and HF (4.0±0.4 pg/mL, n=17, P &lt;0.005). Serum TNF-α receptors did not differ between unused (4.3±0.8 and 8.6±1.6 ng/mL, n=10) and used (3.5±0.4 and 6.5±1.1 ng/mL, n=24) donors. There was a trend for higher serum IL-6 in unused (16.5±2.9 pg/mL, n=9) compared with used (13.9±1.6 pg/mL, n=26, P =NS) donors. Conclusions —This study documented an increase in the expression of TNF-α and IL-6 in the myocardium of all donor hearts that was more marked in the dysfunctional (unused) donor hearts. This was accompanied by similar changes in the serum. This might have important therapeutic implications.
The Gulstonian Lectures, on Malignant Endocarditis
Authors: W. Osler
Journal: BMJ (1885)

side, or fairly braeing in1;nd, places, is oftonikiportant.dur'iig the convalescence from these diseases, but the! fatigue of long, joun"eys is" to be avoided.Preventive medicine has a verv large field in the sub,j;ect of, phthibis.1 need only remind you of the change in the mortality from phthiaig of saldiers and prisoners by improved ventilation in barraeks and prisons; anid w, must always lhave before our minds the important discovery of Bowditch and Buchanan, that drying of the soil by drainage dii4inishes the mortality from phthisis.The practical applieation re- quides no words.
Thoracic duct drainage and low back pain
Authors: I. H. Shehadeh
Journal: JAMA (1969)

Forty-seven recipients of renal allografts from living related donors underwent thoracic duct drainage as an adjunct to immunosuppressive therapy. Ten patients complained of severe low back pain upon cessation of lymphatic drainage. In three of these, the pain was promptly relieved by reinstitution of drainage and could be reproduced at will by reclamping the thoracic duct catheter. This observation is related to the anatomy, innervation, and physiology of the thoracic duct.
HEMORRHAGIC GLAUCOMA.
Authors: CHARLES A. OLIVER
Journal: JAMA (1900)

<h3>Frequency.</h3> —Fortunately, this almost universally fatal ocular condition, which, as Stirling says, "must be distinguished from hemorrhage into an already glaucomatous eye," is quite rare in this country. Risley's statistics of 4 in 20,000 cases are similar to mine of 8 in 40,000. <h3>Symptoms.</h3> —Following an intraocular hemorrhage that is, as a rule, due to some gross disturbance of the vascular system, such as endarteritis or thrombosis, it is either rapidly, or even suddenly, announced by all the expressions of a subacute or an acute attack of glaucoma. Ophthalmoscopically, if at all visible, the main retinal veins will appear engorged and tortuous, this being particularly noticeable in the larger stems as they bend into the optic nerve-head and pass through its cribriform plate. In these cases, though more particularly in the more pronounced ones, or, at times, in those eyes in which there has been a partial or a complete
Quantifying Leukemia
Authors: Alec Morley
Journal: New England Journal of Medicine (1998)

Measurement is the backbone of science, and the science of hematology is no exception. For many years, the number of normal or abnormal cells in the blood and bone marrow has been determined by counting cells visually or electronically and identifying them by microscopical inspection. In biologic terms, these traditional methods have very limited sensitivity, but recently developed, more sensitive techniques are providing new information of theoretical and practical value. The report by Cavé et al. in this issue of the Journal 1 indicates the value of a molecular method of quantifying leukemic cells in patients with acute lymphoblastic leukemia (ALL) . . .
Cryosurgery or microsurgery in the management of acromegaly
Authors: G. M. Teasdale
Journal: JAMA (1982)

Fifty-six patients with growth hormone-secreting pituitary adenomas, 28 treated by cryoablation and 28 by microsurgery, have been followed up from three to eight years. Mean serum growth hormone concentrations were less than 10 mU/L in 19 patients (68%) after microsurgery as compared with seven (25%) after cryosurgery. Hypopituitarism and operative complications were more frequent after cryosurgery. Transsphenoidal microsurgery was particularly successful in reducing growth hormone secretion without impairing normal pituitary function, when the patient had not been previously treated by another method. (<i>JAMA</i>1982;247:1289-1291)
Ætiology of Phthisis.
Journal: JAMA (1884)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hypocaloric Dwarfism and Hydronephrosis in Diabetes Insipidus
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue Access Provided by Korea University Medical Library JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account
CDC nears close of first half-century
Authors: P. Cotton
Journal: JAMA (1990)

WHAT STARTED AS a small wartime mosquito-eradication effort is now the preeminent epidemiologic agency in the world. CDC activities have swelled to undreamed of proportions, covering everything from a scientific assault on violence to the cloning of the CDC model to other countries. Yet the philosophy and approach remain virtually unchanged with time. "Insofar as [diseases] are preventable, they should not be allowed to develop. The best way to forestall them is to foster training, investigations, and control technology as continuing and permanent elements under federal auspices," said Justin Andrews, MD, deputy chief of the CDC when it was officially established in 1946. The letters then stood for Communicable Disease Center. The CDC evolved out of the Office of Malaria Control in War Areas, which was stationed in Atlanta during World War II to control<i>Anopheles gambiae</i>mosquitoes that posed a threat to soldiers and war-related industrial workers in the
Outlook for impaired physicians with appropriate treatment
Authors: R. E. Herrington
Journal: JAMA (1982)

The results reported by Shore in this issue ofThe Journal(p 3127), like those of others he cites in his article, are generally encouraging and imply an optimistic outlook for the recovery of impaired physicians, particularly those recovering from substance-use disorders. His finding, that 74% of 34 impaired physicians showed improvement on a multivariate criterion of recovery, is indeed a strong and positive indication that a great majority of physicians can resume their medical practice successfully after a period of treatment and with ongoing administrative monitoring and supervision. Moreover, his finding that after more than 3 1/2 years the relapsed physicians were no less likely to be improved than were the nonrelapsers certainly impresses us with the importance of persevering in treatment efforts. Of particular interest is the observation that 79% of the treated physicians had been impaired by substance-use disorders, with an 81.5% improvement rate for that group
FLORENCE NIGHTINGALE (1820-1910)—MILITARY NURSE
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Superfluous Glasses.
Authors: C. M. Hobby.
Journal: JAMA (1894)

Iowa City, Feb. 5, 1894. <h3>To the Editor:</h3> —In the editorial on "Superfluous Glasses," in theJournalof February 3, there are several points which I can heartily indorse, and some, naturally, that seem to me not well taken. I write now because I am preparing an article on asthenopia, based on records of more than a thousand cases seen in private practice, nearly all among professional people and students. The notes do not cover refractive errors alone, but constitutional conditions, general and local diseases, etc. More than six hundred had errors of refraction, and while relief of refractive error has always been to the advantage of the patient, the cure of asthenopia, in my experience, often requires more than simply making the eye the most perfect optical instrument possible, or securing the so called equilibrium of muscular movement of both eyes. Asthenopia occurs with one eye, with emmetropia, hyperopia,
Leads from the MMWR. Update: prevention of Haemophilus influenzae type b disease
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A retrospective multicenter study evaluating the efficacy and safety of irinotecan in patients with advanced gastric cancer: Analysis of Glasgow Prognostic Score (GPS)
Authors: T. Honda, S. Nakano, S. Yuki, K. Sawada, T. Muranaka, Y. Kawamoto, H. Nakatsumi, H. Yoshita, T. Ando, K. Harada, Y. Kobayashi, T. Miyagishima, K. Hatanaka, A. Tanimoto, A. Ishiguro, M. Dazai, T. Sasaki, Y. Komatsu
Journal: Annals of Oncology (2019)
Elevated Cerebrospinal Fluid Substance P Concentrations in Posttraumatic Stress Disorder and Major Depression
Authors: Thomas Geracioti
Journal: American Journal of Psychiatry (2006)

Objective: The authors tested the hypothesis that concentrations of the pain-transmitting neuropeptide substance P are elevated in the CSF of patients with major depression or posttraumatic stress disorder (PTSD), which have overlapping symptoms. The authors also sought to determine if CNS substance P concentrations change on provocation of symptoms in PTSD patients. Method: The authors measured CSF substance P concentrations in medication-free patients with either major depression or PTSD and in healthy comparison subjects. Next, using a within-subject, crossover design, the authors sampled CSF for 6 hours through an indwelling subarachnoid catheter in PTSD patients before, during, and after exposure to a 60-minute traumatic or neutral videotape stimulus. Results: Both depressed and PTSD patients had significantly elevated basal CSF substance P concentrations. In the challenge study, marked increases in CSF substance P concentrations were found only after precipitation of PTSD symptoms. CSF substance P concentrations increased by 169% and 90.6% of baseline levels at 10 and 70 minutes, respectively, after the start of the traumatic videotape but changed by only 1.1% and –8.1% of baseline levels 10 and 70 minutes after the start of the neutral videotape. Conclusions: These results suggest that elevated CNS substance P concentrations are involved in both major depression and PTSD. The marked increase in CSF substance P concentrations during and after the symptom-provoking stimulus, but not after the neutral stimulus, implicates CNS release of substance P in the mechanism of acute PTSD symptoms. These data also reveal that CNS substance P responds acutely to psychological stress in humans.
Announcement
Authors: Klaus Engel, Michael Stienen, Karin Barth, Geir Nielsen, Odd E. Havik, Brit Haver, Klaus Engel, Ester Mølstad, Henrik Rogge, Marit Skåtun, Astrid Nøklebye Heiberg, Holger Ursin, Johan Vanderlinden, Walter Vandereycken, James Georgas, Eliza Giakoumaki, G. Lavrentiadis, N. Manos, J. Christakis, C. Semoglou, K.R. Scherer, B. Zei, Heinz Schepank, Per Høglend, T.G. Sriram, L. Pratap, V. Shanmugham, Hans Kordy, Michael von Rad, Wolfgang Senf, Asbjorn O. Faleide, Vigdis Kjaer Galtung, Sissel Unger, Reidulf G. Watten, Akira Ikemi
Journal: Psychotherapy and Psychosomatics (1988)
Incorrect Word and Value
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Gordon Research Conferences
Authors: H. G. Schlumberger, Frederik B. Bang
Journal: JNCI Journal of the National Cancer Institute (1958)

Gordon Research Conferences H. G. Schlumberger, H. G. Schlumberger chairman Search for other works by this author on: Oxford Academic PubMed Google Scholar Frederik B. Bang Frederik B. Bang vice-chairman Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 20, Issue 4, April 1958, Pages 859–860, https://doi.org/10.1093/jnci/20.4.859 Published: 01 April 1958
Connections
Authors: Georgia Anne Thomas
Journal: JAMA (1991)

My baby is sick. I fall into a terror so disorienting that it feels like my old nightmare of stepping into a twilight world patterned like an abstract expressionist painting. Silence and sharp, angular structures are everywhere, hurting me when I try to find my way home. I cannot afford to take a deep breath, but I also cannot cry yet. It's very early in the morning—a Texas winter. The trees are dark and green against our bedroom windows; the air is cold and still. When I woke him for his bottle I still wanted to believe he only had viral gastroenteritis. In my arms he vomits propulsively, begins to wail, then abruptly falls silent. The physician inside this terrified mother notes in a flash of insight that I am observing the joint clinical manifestations of lethargy and irritability—remembering how strange I used to think it was that such polar
Roughness
Authors: Juliet Aizer
Journal: Annals of Internal Medicine (2012)

Ad Libitum7 August 2012RoughnessJuliet Aizer, MD, MPHJuliet Aizer, MD, MPHHospital for Special Surgery, New York, NY 10021Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-157-3-201208070-00016 Audio Reading - “Roughness” Audio. Listen to a reading of "Roughness" by Juliet Aizer, MD, MPH. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail As if we haven't ever wiped a tear, a nose of our ownnever studied the anatomy, don't know the sensitivitydon't careI am sorry we have the roughest tissues on the marketor Let me see I should be able to get you some amazingly rough tissues(the time it takes for a steadying breath)postures soften, a hint of a smileconcern conveyed I thinkThose commentsmumbled and stumbled upon oncethen kept like a favorite story to tell in the right settingbeside the stacked boxesWho has thoughtHow considerate to have such soft tissuesAnd of course pointing it out would not doJuliet Aizer, ... Author, Article, and Disclosure InformationAffiliations: Hospital for Special Surgery, New York, NY 10021Current Author Address: Juliet Aizer, MD, MPH, Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021; e-mail, [email protected]. PreviousarticleNextarticle Advertisement Audio Reading - “Roughness” Audio. Listen to a reading of "Roughness" by Juliet Aizer, MD, MPH. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 7 August 2012Volume 157, Issue 3Page: 216KeywordsPostural controlSoft tissuesSurgery ePublished: 7 August 2012 Issue Published: 7 August 2012 Copyright & PermissionsCopyright © 2012 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
RESPONSE: Re: Chemoprevention of Gastric Dysplasia: Randomized Trial of Antioxidant Supplements and Anti-Helicobacter pylori Therapy
Authors: P. Correa, E. T. H. Fontham, J. C. Bravo, L. E. Bravo, B. Ruiz, G. Zarama, J. L. Realpe, G. T. Malcom, D. Li, W. D. Johnson, R. Mera
Journal: JNCI Journal of the National Cancer Institute (2001)
Organization Section
Authors: Roger Austin, Dewey Bailey, Thomas Baker, Christina Baldwin, W Barry, Isaac Bercovitz, Kris Berg, Charla Berry, Mary O Blatz, Dennis Boston, R Kirby Bowen, Mary Callan, Joseph Caporusso, San Antonio, Melissa Crowe, San Francisco, Steven Degelsmith, Granada Hills, Martha Elks, Manfred Ernesti, Ma Evans, Leanne Fleagle, Diane Fonner, Gregory Foster, Martin Fox, Howard Foyt, Linda Fullerton, Edward Garr, Sarita Gonzales, Holly Grant, David Harlan, Patricia Heath, Shira Hedgepeth, Marcia Hendricks, Chas Hilton, Michael Hosford, Renn Oshi, Claire Karis, Lanice Katucki, Linda Krasnisky, Mary Leder, Nancy Levin, Des Plaines, Ronald Lynch, Larry Magnuson, Kazuhiro Masuda, Rosa Matonti-Mal, Las Vegas, Roger Mccartney, Brenda Menier, Patrice Niquille, Robert Olney, Palo Alto, Roberta Pang, Elizabeth Paz-Pacheco, Ma Boston, Michel Tallahassee, Edward Polak, Ann Post, Angelique Arbor, San Ramirez, Norma Diego, Judy Salem, Fred Roemerman, Kristine Romano, Ghand Rumney, Michael Saadeh, Christopher Schaefer, David Scheidt, Mark Scoffield, Robert Snyder, Beverly Spurs, Lori Strauss, John Swan, Hans Tandra, Susanne Welbourne, Harriet Williamson, Ping Wong
Journal: Diabetes Care (1991)