tbuckley/cabot-search huggingface dataset:
LONDON
Journal: JAMA (1929)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Unarranged
Authors: Sharon Pretti
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CHILDREN IN HOSPITAL
Authors: None Cohen Of Birkenhead, H.M.T. Coles, L.G. Kingdom, C.W. Kesson, Margaret Manford, R.H. Metcalfe, H.H. Nixon, P.K. Orton, E.D.L. Simpson, G.T. Stbwart, R.G. Thomas, B.C.H. Ward
Journal: The Lancet (1959)
THE AMEBIC DYSENTERY EPIDEMIC
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
My Condolences
Authors: Vikram Padmanabhan
Journal: Annals of Internal Medicine (2008)

On Being a Doctor21 October 2008My CondolencesVikram Padmanabhan, BS, MAEdVikram Padmanabhan, BS, MAEdFrom Albert Einstein College of Medicine, Bronx, NY 10461.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-149-8-200810210-00013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail “All I want is a way to clean myself after I make a mess.”I began mentally reviewing my patient's CT findings: metastatic cervical cancer to the lungs, lumbar spine, and liver and left lower-extremity deep venous thrombosis. I spent most of the previous night poring over the literature: How do I talk to her about her “goals of therapy”? Can I search PubMed for a script? The books state that in medicine, there are 2 options for therapy: curative versus palliative—black and white in a world full of grays. What does “palliative” mean to a 36-year-old mother of 2, ... Author, Article, and Disclosure InformationAffiliations: From Albert Einstein College of Medicine, Bronx, NY 10461.Corresponding Author: Vikram Padmanabhan, BS, MAEd, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Box 546, Bronx, NY 10461; e-mail, [email protected]yu.edu. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDeterminants of Medical Students' Perceived Preparation To Perform End-of-Life Care, Quality of End-of-Life Care Education, and Attitudes Toward End-of-Life Care 21 October 2008Volume 149, Issue 8Page: 591-592KeywordsBloodChildrenComputed axial tomographyIntensive care unitsLungsPalliative careSpineUreaUreterUrine ePublished: 21 October 2008 Issue Published: 21 October 2008 Copyright & PermissionsCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Iron in Enriched Wheat Flour, Farina, Bread, Buns, and Rolls
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Announcement Spotlight Issue on New Roles of Nitric Oxide in Cardiovascular Signaling
Journal: Cardiovascular Research (2006)

A Spotlight Issue on the new roles of nitric oxide (NO) in cardiovascular signaling is scheduled to appear in July, 2007, that will address the main topics which have emerged in recent years concerning the roles of NO in cardiovascular physiology and pathophysiology.In particular, the issue will focus on new aspects of intercellular signalling and intracellular signal transduction in the vascular wall and cardiac tissue where NO is an active player.Preliminary topics of invited review articles related to the new roles of NO in cardiovascular signaling include:
On a New Therapeutic Method Consisting in the Use of Organic Liquids Extracted from Glands and Other Organs
Authors: C. E. Brown-Sequard
Journal: BMJ (1893)

at the Paris School of.Medicine, I delivered several lectures, the principal object of which was to establish that all glands, with or without excretory ducts, give to the blood, by an internal secretion, principles which are of great import-
Journal of Chronic Diseases, St. Louis
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Carcinogenicity of Saccharin
Authors: Melvin Dwaine Reuber
Journal: Environmental Health Perspectives (1978)

Saccharin is carcinogenic for the urinary bladder in rats and mice, and most likely is carcinogenic in human beings. The neoplasms of the urinary bladder are malignant and invade and metastasize. Male rats are more susceptible to urinary bladder carcinogenesis than female rats. Rats exposed as fetuses develop neoplasms more readily than rats exposed as weanlings. The lesions in the urinary bladder go through the stages of hyperplasia, hyperplastic nodules, and later carcinomas. The male of the human species ingesting saccharin, as for rats, is more susceptible to carcinogenesis of the urinary bladder than the female. Neoplasms of the urinary bladder in rats were not caused by stones, parasites, sodium, or impurities. There is a cocarcinogenic effect between saccharin and methylnitrosurea for the urinary bladder. Even through carcinomas of the urinary bladder are present in rats given the higher doses of saccharin, one was observed in a female rat given 0.5%. Chronic renal disease develops in rats ingesting saccharin. The disease is more advanced at the lower doses than at the higher doses, suggesting that saccharin at the lower doses does not reach the urinary bladder. Early neoplasms are seen in the renal pelvis of rats given the higher doses of saccharin. The risk ratios for urinary bladder carcinomas in human beings increase with both frequency andduration of saccharin usage. Benign and malignant neoplasms at all sites are significantly increased in mice and rats ingesting the higher doses of saccharin. These neoplasms are present in the reproductive and hematopoietic systems, and to a lesser extent in the lungs, vascular system and squamous epithelium. Neoplasms in some organs develop with the lower doses of saccharin. Lymphosarcomas of the lung are significantly increased in rats given 0.01% saccharin. Chronic renal disease in rats given saccharin interferes with the health and life span and consequently with development of neoplasms. Saccharin initiates neoplasms of the skin when its application is followed by croton oil. Epidemiological studies have not been done for neoplasms other than the urinary bladder in human beings.
Premenstrual Fever
Authors: Hobart A. Reimann
Journal: JAMA (1961)

<h3>To the Editor:—</h3> The answer to the question about premenstrual fever inThe Journal, Oct. 29, 1960, page 1221, is incomplete. Premenstrual "fever" occurs in some women beginning at ovulation and ending at the beginning of the flow. It rarely rises to 105° F. (40.6° C.), but unusual instances no doubt happen. The menstrual period may be preceded or accompanied by edema, purpura, neutropenia, and other reactions as well. It is doubtful that antimicrobics influenced the fever as stated in the query.
Light Reflectance from the Ocular Fundus
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 262: Myofibroblast-Specific Transforming Growth Factor β Suppression Reduces Fibrosis in a Proteotoxic Cryab <sup>R120g</sup> Mouse Model of Heart Failure
Authors: Bidur Bhandary, Qinghang Meng, James Gulick, Hanna Osinska, Kritton Shay-Winkler, Jeffrey Robbins
Journal: Circulation Research (2017)

Introduction: Transforming Growth Factor beta (TGFβ) is an important cytokine in mediating cardiac fibrosis. Cardiomyocyte-specific expression of a mutant αB-crystallin (CryAB R120G ) that is responsible for human Desmin Related Myopathy results in significant cardiac fibrosis and cardiac remodeling leading to heart failure. Onset of fibrosis is initiated by the activation of a quiescent fibroblast population to an active, “myofibroblast” state and TGFβ binding is thought to mediate an essential signaling pathway underlying this process. Our central hypothesis is that myofibroblast-based TGFβ signaling can result in significant cardiac fibrosis. Here, we have partially ablated TGFβ signaling in cardiac myofibroblasts to observe if cardiac fibrosis is altered. Objective: To understand the contributions of myofibroblast-based TGFβ signaling to the development of cardiac fibrosis. Methods and Results: To test the hypothesis we partially ablated myofibroblast specific TGFβ signaling by crossing CryAB R120G mice with mice containing a floxed allele of TGFβ’s receptor 1 (TGFβr1). The double transgenic animals were further crossed with activated myofibroblast specific Cre mice in which Cre expression was driven off the periostin promoter so that TGFβr1 would be ablated subsequent to myofibroblast conversion as the periostin promoter became active. Echocardiography, Masson’s Trichome staining, the hydroxyproline assay, PCR arrays, immunohistochemistry and western blots were used to characterize fibrosis and cardiac function in mice lacking TGFβr1 in the myofibroblasts were used to characterize the resultant animals. Conclusion: Myofibroblast-targeted knockdown of Tgfβr1 signaling resulted in reduced fibrosis and improved cardiac function.
Graduated patient responsibility
Authors: W. J. Grace
Journal: JAMA (1975)

GRADUATED Patient Responsibility is supervised patient care in the setting of medical education. It is based on the premise that the vast majority of medical students and house staff are responsible individuals who are fully cognizant of the importance of their work. How, then, does one take a responsible person in a "learning" situation and allow him to assume patient care commensurate with the level of his achievement and medical competence? Can this be done and supervised in such a way as to assure growth and progress of the student? How do we protect the patient from inexperience? If Graduated Patient Responsibility is to function for the benefit of all, appropriate supervision must prevail at all levels. The "student" of medicine, be he clerk, intern, or resident, must not be permitted to flounder about in a sea of confusion, uncertainty, and misdirection. He cannot be left to "work it out
Pseudoscleroderma in hypertrophic osteoarthropathy
Authors: R. G. Gray
Journal: JAMA (1981)

EDEMA and induration of the skin that clinically resemble the dermal lesions of progressive systemic sclerosis have been reported in diverse disorders (Table).<sup>1-3</sup>We describe a patient with scleroderma-like skin changes that preceded other findings of tumor-associated hypertrophic osteoarthropathy, resolving rapidly after lobectomy for lung carcinoma. <h3>Report of a Case</h3> A 39-year-old woman was seen in January 1977 with a three-week history of bilateral ankle pain that was neither aggravated by weight bearing nor relieved by rest or elevation. She denied trauma, Raynaud's phenomenon, dermatitis, skin or hair changes, alopecia, previous serositis, oral ulcers, ocular or gastrointestinal symptoms, fever, weight loss, dyspnea and cough, morning stiffness, and family history of inflammatory rheumatic disease. A total abdominal hysterectomy and bilateral salpingo-oophorectomy for menometrorrhagia were performed seven years earlier; a 45 pack-year history of cigarette smoking was related. Physical examination showed a healthy woman with tenderness over the anterior tibiotalar joint
Members of the House of Delegates
Journal: JAMA (1984)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The future of rural maternity units
Authors: A. S. Cunningham
Journal: JAMA (1986)

<h3>To the Editor.—</h3> Hein<sup>1</sup>pleads for the preservation of rural maternity units and, based on regionalized perinatal care in Iowa, shows that they can provide excellent care at reasonable cost. Iowa's experience parallels that of New Zealand, where the smallest maternity units have the lowest perinatal mortality rates.<sup>2</sup>Perinatal care in upstate New York is not so well organized. Recent data highlight certain problems that add perspective to Hein's observations. Excluding New York City, the neonatal mortality rate in 1983 for all babies born in hospitals with fewer than 500 annual births was 6.6 per 1000. The same hospitals in Iowa (Hein's class Ia) had a rate of 2.7. There must be several reasons for this difference, but an important one is that too many high-risk babies are still being delivered in small hospitals asNew York's system of perinatal care continues to evolve. Table 1 shows that
Intrauterine Surgery
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mortality from myocardial infarction
Authors: B. Monroe
Journal: JAMA (1982)

<h3>In Reply.—</h3> Buehler and Sullivan have expressed concern in the use of Liquisol (Damon Diagnostics) free T<sub>4</sub>assay in patients with nonthyroidal illness (NTI) as described in our report. The interpretation of thyroid function tests in NTI must be undertaken with the knowledge that the "true" state of thyroid function in these persons is unknown, although most observers agree they are clinically euthyroid. The contention that the Liquisol assay provides "excellent clinical correlation," providing their normal reference ranges are used, overlooks a critical clinical situation. Using either the reference range we determined in our own control subjects or using the reference range given with the Liquisol kit literature (0.8 to 2.4 ng/dL), the assay failed to identify both patients in our report with primary hypothyroidism and associated NTI. Recently, others have shown that Liquisol assay for free T<sub>4</sub>failed to identify 50% of persons with uncomplicated hypothyroidism.<sup>1</sup>
Platelet Production
Authors: L. A. Harker
Journal: New England Journal of Medicine (1970)

PhysiologyMEGAKARYOCYTES arise from mononuclear precursors and undergo nuclear replication within a common cytoplasm as the initial identifiable phase of the life cycle of the cells. The number of nuclei doubles with each mitosis. In normal bone marrow about 65 per cent of the megakaryocytes contain eight diploid nuclei, 25 per cent have 16 nuclei, and 10 per cent have four nuclei.1 , 2 The cell then accumulates cytoplasm in direct proportion to the number of nuclei formed during nuclear proliferation — that is, the cell consists of four, eight or 16 "nuclear units."3 Cell maturation, which occurs mainly after nuclear proliferation, . . .