tbuckley/cabot-search huggingface dataset:
Polycystic liver disease. Report of a case with verification by hepatic sonography
Authors: C. J. Sanner
Journal: JAMA (1976)

POLYCYSTIC liver disease is a relatively rare condition with a reported autopsy incidence varying from 1/687 autopsies to 8/11, 245 autopsies.<sup>1-3</sup>Ante-mortem diagnosis is usually made at surgery.<sup>4,5</sup>It is the purpose of this report to discuss the noninvasive approach to the diagnosis of polycystic liver disease and to emphasize the role of abdominal sonography in evaluating selected cases of unexplained hepatomegaly. <h3>Report of a Case</h3> A 53-year-old woman was admitted to a hospital for a whiplash injury in 1971 and was told that she had an enlarged liver. Liver function tests were normal. Liver biopsy was done and reportedly showed cirrhosis. On Dec 3, 1974, the patient was again admitted to another hospital with an acute onset of right upper quadrant pain and with an enlarging mass in that area. Physical examination showed a large, tender liver with an irregular margin. Laboratory studies disclosed normal values for complete blood
Induction of Drug Metabolizing Enzymes in Polybrominated Biphenyl-Fed Lactating Rats and Their Pups
Authors: Robert W. Moore, Ghazi A. Dannan, Steven D. Aust
Journal: Environmental Health Perspectives (1978)

Polybrominated biphenyls (PBBs) cause a mixed-type (phenobarbital- plus 3-methylcholanthrene-like) induction of liver microsomal drug metabolizing enzymes in rats. However, 2,2',4,4',5,5'-hexabromobiphenyl and 2,2',3,4,4',5,5'-heptabromobiphenyl, which together comprise less than 80% of PBBs (FireMaster), were shown to be strictly phenobarbital-type inducers. Other components (unidentified) must therefore cause the 3-methylcholanthrene-like effects. The potential for PBBs to exert effects on neonates through milk was examined. Lactating rats were fed 0, 0.1, 1.0, or 10 ppm FireMaster for the 18 days following delivery, at which time mothers and most pups were sacrificed. Pups nursing from mothers fed 10 ppm PBBs showed significant increases in liver weights and microsomal protein, and both mothers and pups had increased cytochrome P-450, aminopyrine demethylation, benzo[a]pyrene hydroxylation, and UDP-glucuronyltransferase. Pups nursing from rats fed 1.0 ppm had increases in microsomal protein, cytochrome P-450, aminopyrine demethylation, and benzo[a]pyrene hydroxylation, while their mothers were unaffected. Several pups from the 0, 0.1, and 1.0 ppm groups were maintained on their mother's diets, raised, and allowed to mate. Their pups showed much the same responses to PBBs as did the original group of pups. The effects on both generations of adult female rats were also comparable. PBBs cause a mixed-type induction in both lactating rats and their nursing pups; PBB components responsible for both aspects of this induction must be transmitted through milk. Nursing rats are approximately tenfold more sensitive to the effects of PBBs in their mother's diets than are the dams. The approximate no-effect level for microsomal induction in nursing rats is 0.1 ppm PBBs in the diet of the adult.
Do von Willebrand victims have less plaque?
Authors: P. Gunby
Journal: JAMA (1980)

There now is a registry of patients with the congenital coagulation disorder called von Willebrand's disease, particularly the more severe forms. National Heart, Lung, and Blood Institute (NHLBI) officials in Bethesda, Md, say that when the needed technology becomes available—probably in the form of refinements in ultrasound equipment and techniques—some of these patients probably will be asked to take part in prospective studies on the development of atherosclerosis. One hypothesis is that at least the severe forms of von Willebrand's disease (named for the Finnish physician who first reported it in 1926) may protect against atherosclerosis. If ultrasound monitoring lives up to expectations, it may be possible to study the blood vessels of such patients noninvasively to see if atherosclerotic plaque forms. According to the NHLBI, 344 patients on the list are classified as having severe von Willebrand's disease, while 115 have less serious forms. Harvey J. Weiss, MD, professor
Nonrandom chromosomal rearrangements of 14q32.3 and 19p13.3 and preferential deletion of 1p in 21 patients with multiple myeloma and plasma cell leukemia
Authors: M Taniwaki, K Nishida, T Takashima, H Nakagawa, H Fujii, T Tamaki, C Shimazaki, S Horiike, S Misawa, T Abe
Journal: Blood (1994)
Abstracts
Journal: Annals of the Rheumatic Diseases (1958)

The results are reported of a psychiatric study of eight patients with Sydenham's chorea admitted to the Children's Mercy Hospital, Kansas City, over a period of 18 months.The personality of the patients was marked by passivity, with inability to express anger or assertion or to accept with equanimity the hostility of others.There was withdrawal from interpersonal relationships, varying from that of extreme shyness to schizophrenia, and much basic anxiety and suppressed anger.Depression and phobic and obsessive symptoms were noted in some of the children, one of whom could be assertive and angry, but later experienced strong feelings of guilt as a consequence.Two were definitely schizophrenic and five were schizoid; seven of the patients were the eldest or second eldest in the family.None of the patients' siblings had suffered from Syden- ham's chorea.The sex incidence was equal and the ages ranged from 7 to 16 years.No evidence of rheumatic fever was found in three cases, and in one other it was indefinite.In five cases the onset of chorea closely followed severe emotional stress, while in two others the correlation with such stress was equivocal.Brief histories of all eight cases are presented.
TROPICAL BRONCHOPULMONARY MYCOSIS
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Caesarean section rates are too high in Latin America
Journal: BMJ (1999)

Sweetness and sucking have analgesic effect in babiesTreating pain in the newborn is essential for ethical reasons and because pain can lead to decreased oxygenation, haemodynamic instability, or increased intracranial pressure.Simple interventions such as sweet oral solutions or sucking a pacifier can reduce pain in neonates during painful minor procedures.On p 1393 Carbajal et al report the results of a comparison of the analgesic effects of these two simple interventions during venepuncture in neonates by using a behavioural pain scale.They found that the non-nutritive sucking of a pacifier was more effective than the oral administration of 30% glucose or 30% sucrose.A 30% glucose solution, which is readily available in any hospital, showed at least the same analgesic effect as a 30% sucrose solution.A synergistic analgesic effect was observed for sucrose and pacifiers.These simple and safe interventions should be widely used for minor procedures in neonates.
Nonoxynol-9 Spermicide Contraception Use—United States, 1999
Journal: JAMA (2002)

Most women in the United States with human immunodeficiency virus (HIV) become infected through sexual transmission, and a woman's choice of contraception can affect her risk for HIV transmission during sexual contact with an infected partner. Most contraceptives do not protect against transmission of HIV and other sexually transmitted diseases (STDs), and the use of some contraceptives containing nonoxynol-9 (N-9) might increase the risk for HIV sexual transmission. Three randomized, controlled trials of the use of N-9 contraceptives by commercial sex workers (CSWs) in Africa failed to demonstrate any protection against HIV infection; one trial showed an increased risk. N-9 contraceptives also failed to protect against infection with Neisseria gonorrhoeae and Chlamydia trachomatis in two randomized trials, one among African CSWs and one among U.S. women recruited from an STD clinic. Because most women in the African studies had frequent sexual activity, had high-level exposure to N-9, and probably were exposed to a population of men with a high prevalence of HIV/STDs, the implications of these studies for U.S. women are uncertain. To determine the extent of N-9 contraceptive use among U.S. women, CDC assessed data provided by U.S. family planning clinics for 1999. This report summarizes the results of that assessment, which indicate that some U.S. women are using N-9 contraceptives. Sexually active women should consider their individual HIV/STD infection risk when choosing a method of contraception. Providers of family planning services should inform women at risk for HIV/STDs that N-9 contraceptives do not protect against these infections.
Triglyceride concentration and coronary heart disease
Authors: A. M Garber, A. L Avins
Journal: BMJ (1994)

figures hold true at least 400 staff a year may experience post-traumatic stress disorder.Some health care settings have taken steps to reduce problems in staff after incidents,45 but in Britain the best example of an attempt at a co- ordinated programme may be that of the Scottish prison service.It has produced a structured response to assaults on staff, which is supported by a programme ofmanagement education.Immediate care includes the opportunity for privacy followed by a one to one interview with a person in a senior management or counselling position to assess the effects of the assault and allow an opportunity for the victim to talk about it.This is followed by a psychological debriefing.The victim is provided with information on possible psychological effects of the assault and on how to seek help if symptoms persist.Longer term care, if needed, is provided by an experienced clinical psychologist.Care is supplemented by the involvement of management, with flexible allocation of duties.This type of care has gained widespread acceptance even in the previously "macho" culture of the prison service.The NHS must do what it can to prevent its staff-its most important resource experiencing similar problems to those experienced by Bende and Philpott's patient.This can best be done by acknowledging the frequency of violence and by learning from the example of other organisations and providing structured support for staffvictims.
Book Review Manual of the International List of Causes of Death. Based on the fifth decennial revision by the International Commission, Paris, October 3-7, 1938. Manual of Joint Causes of Death . Fourth edition, 1939. Prepared under the supervision of Halbert L. Dunn, M.D. 8°, cloth, 452 pp. Washington: United States Government Printing Office, 1940. $1.25.
Journal: New England Journal of Medicine (1941)
Erythrocyte sensitization and anemia due to isoantibodies in lyophilized pooled plasma
Authors: H. A. Oberman
Journal: JAMA (1966)

EARLY in this century it was thought that the isoantibodies in group O blood were of no consequence to recipients of other blood groups. This soon was proved incorrect by reports of intravascular hemolysis following use of this blood in such a manner.<sup>1</sup>As a result, only group O bloods having low saline anti-A and anti-B titers (less than 1:50), low immune anti-A and anti-B titers (less than 1:20) or lacking hemolysins, or group O packed cells are acceptable for transfusion to patients of other blood groups.<sup>2</sup> Not so well recognized is the danger of erythrocyte sensitization and destruction due to isoantibodies in pooled plasma. Such plasma pools are constituted by mixing plasma from donors of the various blood groups, thereby presumably neutralizing and diluting the isoantibodies. Such plasma was used extensively in World War II, with no reports of resultant hemolysis.<sup>3</sup>Shortly after the war, Ebert
Dementia, History
Authors: Patrick Fox
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dilatation of the Colon (Toxic Megacolon) in Acute Fulminating Ulcerative Colitis
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SUPPLEMENTARY COMMENTS ON THE RECENT WORK ON THE PNEUMOCOCCUS.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
<i>Notes from the Field</i>: Evidence of Zika Virus Infection in Brain and Placental Tissues from Two Congenitally Infected Newborns and Two Fetal Losses — Brazil, 2015
Authors: Roosecelis Brasil Martines, Julu Bhatnagar, M. Kelly Keating, Luciana Silva-Flannery, Atis Muehlenbachs, Joy Gary, Cynthia Goldsmith, Gillian Hale, Jana Ritter, Dominique Rollin, Wun-Ju Shieh, Kleber G. Luz, Ana Maria de Oliveira Ramos, Helaine Pompeia Freire Davi, Wanderson Kleber de Oliveria, Robert Lanciotti, Amy Lambert, Sherif Zaki
Journal: MMWR Morbidity and Mortality Weekly Report (2016)
Splinting vs Surgery for Carpal Tunnel Syndrome
Authors: Benjamin M. Sucher
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Course of Lectures on Venereal Affections Delivered at the Hopital Du Midi, Paris
Authors: P. Ricord
Journal: BMJ (1843)

toms-Diagnosis-Employment of the speculum uteri.GENTLEMEN,-Before we enter upon the history of gonorrhreal ophthalmiia, I think it is an indispensable complement of the description of blenorrhagia to allude to the peculiarities presented by this disease when it occurs in women.The vulva, urethra, vagina, and uterus, may be either simultaneously or separately affected.Let me premise that communicated gonorrheia is far more frequent in the male than in the female subject, perhaps in the proportion of four to one.Young persons are more easily infected than full-grown women, and that, during the performance of the catamenial function, females are, in a great measure, protected against contagion.Premonitory signs are generally absent, and even the first symptoms of the incipient stage may escape our notice, on account of the great abundance of natural secretions in those parts.
Proposal to make investigational new drugs available without clinical trial participation in certain cases is receiving mixed responses
Authors: C. Marwick
Journal: JAMA (1987)

A LONG-standing controversy over allowing patients access to drugs before Food and Drug Administration (FDA) approval has surfaced again with revival of a 1983 proposal to make it easier for some patients to obtain certain experimental drugs. The proposed change has appeared in the<i>Federal Register</i>, and is expected to take effect in a few days. In one respect the FDA's new proposal codifies a decade-long but ad hoc situation. This has to do with so-called compassionate investigational new drugs (INDs). In certain circumstances and on a case-by-case basis, compassionate INDs have allowed patients access to a drug still under investigation. Under the new proposal, the agency would permit the physician of a patient with a life-threatening or serious illness to obtain an experimental drug, if it is likely the patient would benefit and even if the patient is not participating in a clinical trial of that drug. The FDA's
The ERCC1 C8092A polymorphism and grade III/IV gastrointestinal (GI) toxicity in non-small cell lung cancer (NSCLC) patients treated with chemoradiation
Authors: R. Suk, S. Gurubhagavatula, S. Park, W. Zhou, L. Su, T. J. Lynch, J. C. Wain, D. Neuberg, G. Liu, D. C. Christiani
Journal: Journal of Clinical Oncology (2004)

2014 Background: ERCC1 is the lead enzyme in nucleotide excision repair of platinum-induced DNA adducts. The ERCC1 C8092Apolymorphism may lead to an altered capacity to regenerate chemotherapy-damaged normal tissue and greater treatment-related toxicity. Methods: Using logistic regression models, we evaluated the ERCC1 C8092Apolymorphism and its association with the occurrence of Grade III or IV toxicity in 147 locally advanced and metastatic NSCLC patients treated first-line with chest radiation and platinum-based chemotherapy. Results: Median age was 62 yrs; 50% were male; 93% had ECOG PS 0/1; 6% had inoperable early stage disease, 46% were stage IIIA, 39% were stage IIIB, and 9% were stage IV. Forty-two percent received cisplatin and 58% received carboplatin. Thirty-one (21%) patients experienced Grade III/IV GI toxicity (nausea, n=10; vomiting, n=4; esophagitis, n=20). After adjusting for type of platinum agent and PS, patients carrying at least one ERCC1 variant allele (C/A, A/A) were found to have an increased risk of GI toxicity compared to patients with the C/Cgenotype (see table), with similar results in a subgroup analysis on the 125 stage IIIA/B patients. Incidence of Grade III/IV toxicity from all causes was non-significantly increased in patients carrying the variant ERCC1allele (OR=1.84, 95% CI: 0.92–3.65, p=0.08). ERCC1 polymorphism was not associated with Grade III/IV hematologic toxicity (p=0.44). Conclusions: Carrying at least one ERCC1 8092Aallele is associated with a greater than two-fold increase in Grade III/IV GI toxicity among NSCLC patients treated with chemoradiation. Supported by NIH grants CA074386, CA71345. No significant financial relationships to disclose.