tbuckley/cabot-search huggingface dataset:
Treatment of patients with hepatitis C and normal serum aminotransferase levels
Authors: Bruce R. Bacon
Journal: Hepatology (2002)

Approximately 30% of patients with chronic hepatitis C have normal serum alanine aminotransferase (ALT) levels and another 40% have ALT levels that are less than twice the upper limit of the normal range. Most patients with normal ALT levels have mild degrees of inflammation with mild or no fibrosis, and the rate of disease progression is reduced compared with that in patients with elevated ALT levels. Some patients with normal ALT levels have advanced fibrosis and cirrhosis on liver biopsy. Treatment of patients with normal ALT levels with either interferon monotherapy or interferon/ribavirin combination therapy has shown sustained virological response (SVR) rates that are equivalent to those achieved for patients with elevated ALT levels. Thus, patients with chronic hepatitis C should not be excluded from therapy based on ALT levels alone. The decision to initiate therapy with interferon and ribavirin should be based on a combination of factors independent of ALT levels including amount of fibrosis on liver biopsy, hepatitis C virus (HCV) genotype and viral level, patient age and motivation, and co-morbid illness, and the presence of other complicating conditions. (Hepatology 2002;36:S179-S184).
Carcinoma and colitis
Authors: D. J. Fleischli
Journal: JAMA (1967)

Dr. Donald J. Fleischli: This 43-year-old woman was in good health until six months before admission to the hospital when she became intermittently constipated. Three months later her constipation was accompanied by crampy pain in the lower part of the abdomen. The pain became severe and was accompanied by vomiting. When admitted to a nearby hospital, she was unable to move her bowels. Shortly after admission, however, profuse diarrhea spontaneously developed with relief of obstructive symptoms. Findings from physical examination and routine laboratory studies were within normal limits. A barium enema was performed at that hospital (Figure). <h3>Discussion</h3> Dr. Laurence L. Robbins: Dr. Tomchik, what do you see to account for her problems? Dr. Frederick S. Tomchik: There is an eccentric, partially constricting lesion in the sigmoid colon. It is somewhat sessile and has a central area of ulceration as well as shelf-like edges which suggest tumor. Carcinoma causing partial
Conditional knockout of TMEM16A/anoctamin1 abolishes the calcium-activated chloride current in mouse vomeronasal sensory neurons
Authors: Asma Amjad, Andres Hernandez-Clavijo, Simone Pifferi, Devendra Kumar Maurya, Anna Boccaccio, Jessica Franzot, Jason Rock, Anna Menini
Journal: The Journal of Experimental Medicine (2015)

Chemosensation is used by animals to obtain information from the environment and to regulate their behavior.In most mammals, both the main olfactory epithelium and the vomeronasal epithelium are involved in chemodetection (Brennan, 2009;Tirindelli et al., 2009;Touhara and Vosshall, 2009).Sensory neurons in these epithelia detect chemicals and, through different second messenger-mediated transduction pathways, generate action po ten tials that are transmitted to different regions of olfactory bulbs.In vomeronasal sensory neurons, the binding of chemicals with vomeronasal receptors occurs in the microvilli, at the apical region of the neuron's dendrite.In rodents, these neurons express one or a few members of three families of G protein-coupled receptors: V1Rs, V2Rs, and formyl peptide receptors (FPRs) (
The Postmenopausal Estrogen/Progestin Interventions Trial
Authors: Fredrick R. Abrams
Journal: JAMA (1995)

<h3>To the Editor.</h3> —With all due respect to the numerous institutions and conscientious physicians who participated in the Postmenopausal Estrogen/Progestin Interventions (PEPI) trial research project,<sup>1</sup>there is a serious shortcoming that must be addressed. Those of us who practiced medicine in the 1970s and 1980s became unhappily aware of the incidence of premalignant and malignant endometrial lesions induced by unopposed estrogen. This was amply confirmed by the literature, and the entire enterprise of estrogen replacement fell into disrepute until concomitant progestin therapy was added.<sup>2-5</sup> In the face of this knowledge, the addition of an unopposed estrogen arm to the PEPI project needlessly exposed patients to a foreseeable harm that, in fact, the published outcome demonstrated to have occurred. Despite the precaution of periodic endometrial biopsies, major surgical interventions became necessary. Minimal risks may be accepted by an informed subject, but only if there is no other way to
Questions and Answers
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Simultaneous versus staged resection for synchronous colorectal cancer liver metastases: A population-based cohort study.
Authors: Pablo Emilio Serrano Aybar, Jessica Bogach, Julian Wang, Sameer Parpia, Julie Hallet, Marko Simunovic
Journal: Journal of Clinical Oncology (2019)

3612 Background: Simultaneous resection of colorectal cancer primary and liver metastases is not performed routinely due to concerns about safety. We hypothesized that simultaneous resection has steadily increased overtime and that the outcomes are similar. Methods: Population-based cohort study of patients undergoing resection for synchronous (resection of the primary colorectal cancer and liver metastases within six months) liver metastases from 2006-2015 by linking administrative datasets in Ontario, Canada. Outcomes: post-operative complications, length of hospital stay, and overall survival. Survival for the staged group was measured from the last surgical resection to death and estimated using Kaplan Meier and compared with the log-rank test. Cox proportional hazard models were used to calculate risks for death. We aimed to identify practice patterns, outcomes of simultaneous vs. staged resections for these patients. Results: Of 2,738 patients undergoing colorectal and liver resection for colorectal cancer, 1,168 were synchronous, of which, 442 underwent simultaneous resection. Rate of synchronous disease presentation increased on average by 3% per year (p = 0.02). Median length of stay was shorter (8 vs. 11 days, p &lt; 0.001); rate of major liver resections were lower (17% vs. 65%, p &lt; 0.001), and 90-day post-operative mortality was higher (6% vs. 1%) for simultaneous resections. Major postoperative complications were higher in the simultaneous group (28% vs. 23%, p = 0.067), mostly due to a higher reoperation rate (6% vs. 3%, p = 0.034). Median overall survival was worse with simultaneous resection (40 months, 95%CI 35-46 vs. 78 months, 95%CI 59-86). Risks factors for worse survival were comorbidities, rurality, right-sided primary and simultaneous resection. There is selection bias that favours survival in the staged group, as patients must have survived the first operation and have stable disease in order to undergo the second operation. Conclusions: Simultaneous resection is associated with worse postoperative outcomes. Considering selection bias, randomized studies would be necessary to determine the role of simultaneous.
Circulation, New York
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Physician's all Requisite Time and Labor-Saving Account Book.
Journal: JAMA (1890)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Inhaled industrial acetylene. A diabetic ketoacidosis mimic
Authors: R. J. Foley
Journal: JAMA (1985)

DIABETIC ketoacidosis is a relatively simple diagnosis in a patient known to have diabetes, yet the differential diagnosis on the initial presentation of a new patient includes all the standard causes of an elevated anion gap acidosis.<sup>1</sup>In a patient with severe anion gap acidosis, hyperglycemia, and ketonuria, the presumptive diagnosis would be diabetic ketoacidosis. Because ketones can elevate serum creatinine levels through chemical interference, an inappropriately elevated serum creatinine level provides indirect evidence for ketosis.<sup>2</sup>The following case report describes a patient with marked anion gap acidosis, hyperglycemia, glycosuria, elevated creatinine levels, and ketonuria who did not have diabetic ketoacidosis or diabetes mellitus. <h3>Report of a Case</h3> A 28-year-old man was brought to the emergency room after being found "down" at his work site 15 minutes after the start of his shift. He was conscious on arrival (30 minutes after being found) and complained of severe chest
The Signature Features of Influenza Pandemics — Implications for Policy
Authors: Cyril Moers, Jacques Pirenne, Andreas Paul, Rutger Ploeg
Journal: New England Journal of Medicine (2012)

of kidneys donated after brain death.Despite the large reduction in delayed graft function by machine perfusion in kidneys donated after circulatory death that we reported previously, 3 we found no beneficial effect of machine perfusion on graft survival in this subgroup.This finding could suggest a different type of delayed graft function in kidneys donated after circulatory death, as compared with those donated after brain death.
Response
Authors: JON J. MICHNOVICZ, H. LEON BRADLOW
Journal: JNCI Journal of the National Cancer Institute (1992)

Journal Article Response Get access JON J. MICHNOVICZ, JON J. MICHNOVICZ Search for other works by this author on: Oxford Academic PubMed Google Scholar H. LEON BRADLOW H. LEON BRADLOW Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 84, Issue 15, 5 August 1992, Pages 1211–1212, https://doi.org/10.1093/jnci/84.15.1211 Published: 05 August 1992
From the Centers for Disease Control and Prevention. Update: barrier protection against HIV infection and other sexually transmitted diseases
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Body Balance and Space Perception
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Indoctrination
Authors: Irina Shklyar
Journal: Annals of Internal Medicine (2014)

Ad Libitum4 March 2014IndoctrinationIrina Shklyar, BSIrina Shklyar, BSFrom Boston, Massachusetts.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M13-2251 Audio Reading - “Indoctrination” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Indoctrination," by I. Shklyar. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail As we crossed the gleaming glass walkwayTo the wards—sterile, off-white, uninvitingThe stars glistened as thoughA hummingbird flew upAnd pierced the sky repeatedlyTenaciouslyTrying to break free from the swathing black fabricAnd remember, he intonedA preacher addressingHis rapt congregationWe are thrust down withThe mendacious filth of earthRotting flesh,And the slithering, wily wormsThat ensnare us dailyWith drug-seeking, litigation, false promisesI shook my head, unwilling and unableTo believeI had seen quiet struggles, smiles of triumphIllness battled with indomitable spiritBut the night team assentedIn world-weary hushed voicesWhile the angry flapOf hummingbird wingsResonated in the air.Irina Shklyar, BSBoston, Massachusetts Author, Article, and Disclosure InformationAffiliations: From Boston, Massachusetts.Current Author Address: Irina Shklyar, BS; e-mail, irina.[email protected]edu. PreviousarticleNextarticle Advertisement Audio Reading - “Indoctrination” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Indoctrination," by I. Shklyar. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 4 March 2014Volume 160, Issue 5Page: 358KeywordsDrugs ePublished: 4 March 2014 Issue Published: 4 March 2014 Copyright & PermissionsCopyright © 2014 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
THE METHOD OF ZADIG IN MEDICINE.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
HIV Diagnoses Among Injection-Drug Users in States With HIV Surveillance--25 States, 1994-2000
Journal: JAMA (2003)

Injection-drug use is a risk factor for acquired immunodeficiency syndrome (AIDS). Of the 765,559 cumulative AIDS cases diagnosed as of December 2000, a total of 193,527 (25%) occurred among injection-drug users (IDUs). IDUs become infected with human immunodeficiency virus (HIV) through sharing injection-drug equipment with HIV-infected persons or by engaging in other risk behaviors such as having unprotected sex. Since 1995, AIDS incidence among IDUs has declined. This report presents data on initial HIV diagnoses among IDUs aged >/=13 years, with and without AIDS at the time of HIV diagnosis, by year, during 1994--2000. The findings indicate that HIV diagnoses among IDUs have leveled in the majority of demographic groups during this period in the 25 states for which HIV surveillance data are available. Because IDUs and their sex partners represent approximately one third of persons infected in the HIV epidemic and continue to be at risk for transmitting HIV, prevention efforts targeting IDUs and their sex partners should be enhanced.
It's never too late to stop smoking. But how old are your lungs?
Authors: T. L. Petty
Journal: JAMA (1993)

It is well-known that smoking is a major contributor to premature morbidity and mortality from cardiovascular diseases, lung cancer and at least six other cancers, and chronic obstructive pulmonary disease. But what is not commonly known is that pulmonary function impairment is a powerful predictor of patients at risk for premature morbidity and mortality from these smoking-related diseases. A reduced forced vital capacity, forced expiratory volume in 1 second, or both identify patients at increased risk of these smokingrelated disease states compared with patients matched by age, sex, and smoking histories who do not have pulmonary function impairment. Accordingly, simple spirometric measurements are both specific and nonspecific predictors of premature mortality from many causes. See also p 2741. More than a century ago, John Hutchinson, MB, a surgeon, invented the spirometer.<sup>1</sup>He offered his device to the insurance industry of London, England, as a potential tool to predict patients
PUBLIC HEALTH.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal