tbuckley/cabot-search huggingface dataset:
Acquired pure megakaryocytic aplasia report of two cases with long‐term responses to antithymocyte globulin and cyclosporine
Authors: Joseph W. Leach, Khader K. Hussein, James N. George
Journal: American Journal of Hematology (1999)

Acquired pure megakaryocytic aplasia is a rare disorder defined by severe thrombocytopenia with no other hematologic abnormalities and absent, or severely decreased marrow megakaryocytes. The etiology may be immune suppression of megakaryocyte development. Two patients are described who both responded rapidly to a combination of antithymocyte globulin and cyclosporine and who remain in remission 13–20 months after discontinuation of cyclosporine. This regimen is well described for treatment of aplastic anemia and may also be effective for acquired pure megakaryocytic aplasia. Am. J. Hematol. 62:115–117, 1999. © 1999 Wiley-Liss, Inc.
A persistent pain
Authors: None The Lancet Neurology
Journal: The Lancet Neurology (2016)

The number of people experiencing chronic pain—pain that lasts longer than 3 months—is substantial, yet treatment for these patients is far from optimum. Long-term opioid use for the management of chronic pain is increasingly prevalent; however, data supporting the long-term efficacy of these drugs, including codeine, oxycodone, and tramadol, are scarce. Opioids can be useful in some circumstances but can also present serious risks. Consequently, prescribing opioids has become very complex, and many experienced physicians are opting out of prescribing them in favour of referring patients to specialists, which may delay the establishment of adequate pain control.
REORGANIZATION OF STATE SOCIETIES.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 371: Assessment of Catheter Position Above or Below the Aortic Valve by Evaluation of Characteristics of the Local Electro Gram: an Acute Canine Study
Authors: Deepak Pa, Chance Witt, Alan M Sugrue, Scott Suddendorf, Joanne Powers, Dejae Ladewig, Budimir Drakulic, Thomas Foxall, Samuel Asirvatham
Journal: Circulation Research (2017)

Background: Ablation in the sinuses of Valsalva (SoV) within the aorta is fraught with risk, owing to the proximity of the coronary arteries. Assessment of catheter tip position is not very easy at this location owing to complex local anatomy and poor images from available modalities. Objectives: We propose the use of novel local unipolar electrogram characteristics using a new signal recording system to guide the assessment of catheter tip position in this region. Methods: We recorded unipolar signals from above the SoV, within the coronaries and below the SoV using the PURE-EP™ (BioSig Technologies, MN) signal processing system in 4 anesthetized canines in the setting of an acute study. We used fluoroscopy, intracardiac echocardiography and angiography for confirmation of the position of the catheter tip. We recorded changes in the signals when transitioning between (1) the coronary arteries and the SoV and (2) the SoV and below the SoV. Results: The unipolar signal showed a negative current of injury (COI) when the catheter tip was present in the SoV, whereas within the coronary artery or below the SoV, the COI was positive. We propose that the difference in the distribution of ventricular muscle below and above the SoV is responsible for this phenomenon. These changes in the COI were noted immediately when transitioning from one location to another and were present reproducibly in all the dogs. ( Figure 1 ) Conclusions: Analysis of the changes on the local electrogram can provide information about the location of the catheter tip which could prove critical in saving lives.
<i>Circulation:</i> Clinical Summaries
Journal: Circulation (2012)

A Nutrient-Wide Association Study on Blood PressureRaised blood pressure (BP) is a major risk factor for coronary heart disease and stroke.Risk increases in graded fashion across the BP range, with substantial risk of death and disability attributed to raised BP at normal and high-normal BPs, below current treatment thresholds.Thus, nonpharmacologic as well as pharmacological approaches are needed to deal with the population-wide BP problem.Dietary habits are known to be related to high BP, but the role of many nutrients is unclear despite intensive research efforts.We used a nutrient-wide association study design to systematically test and validate multiple associations between a wide range of nutrients and BP.We initially tested associations of 82 nutrients and 3 urine electrolytes/electrolyte ratios with BP in a 50% random sample of the population-based study, the International Collaborative Study on Macro-/Micronutrients and Blood Pressure (INTERMAP).Significant findings were validated in the remainder 50% INTERMAP population and among participants in the National Health and Nutrition Examination Survey (NHANES).We identified inverse associations between BP and intake of B vitamins (folacin, riboflavin, thiamin) previously poorly studied, and reidentified sodium-to-potassium ratio and alcohol with BP (direct), and non-heme iron, phosphorus, and magnesium intake with systolic BP (inverse).Our results highlight a complex array of nutritional correlates with BP and emphasize why traditional approaches of testing 1 association at a time may be suboptimal compared with our inclusive nutrient-wide association study paradigm.Findings for BP and B vitamins may represent potentially causative associations, which need to be probed in further observational and interventional studies.See p 2456.
Arcuate NPY Controls Sympathetic Output and BAT Function via a Relay of Tyrosine Hydroxylase Neurons in the PVN
Authors: Yan-Chuan Shi, Jackie Lau, Zhou Lin, Hui Zhang, Lei Zhai, Guenther Sperk, Regine Heilbronn, Mario Mietzsch, Stefan Weger, Xu-Feng Huang, Ronaldo Enriquez, Lesley Castillo, Paul Baldock, Lei Zhang, Amanda Sainsbury, Herbert Herzog, Shu Lin
Journal: Cell Metabolism (2013)
Painful swelling over right tibia
Authors: T. E. Shea
Journal: JAMA (1967)

Dr. S. Boyd Eaton: A 43-year-old construction worker sustained minor trauma to his right tibia 11 months prior to admission to the hospital. He consulted a physician at that time and was assured that there had been no significant bony injury. Despite this he continued to have slight swelling and mild pain at the site of injury. The pain gradually increased in severity over the ensuing months and he again sought medical attention. Physical examination revealed a small hard mass over the anterior region of the tibia about 5 cm below the tibial tubercle. There were no other significant physical findings and the laboratory values were within normal limits. <h3>Discussion</h3> Dr. Laurence L. Robbins: Dr. Weber, how would you interpret this case? Dr. Alfred L. Weber:There is an obvious lytic lesion in the upper shaft of the right tibia, and there is erosion of the anterior cortex on its
Correction
Journal: BMJ (1949)

ANY QUESTIONS?MICALJOURNAL in the baby were related to a noxious agent in the milk.Indeed, the whole picture suggests that the basis is one of over-anxiety.Colonic spasm is likely to be the cause of the left-sided pain and to give rise to occasional right-sided pain from the caecum.The abdominal discomfort has probably always been of bowel origin, and the ovary which was removed was blameless.The general disturbance associated with menstruation represents exaggerated molimina, amounting to what is sometimes called a " menstrual tension state," which again often has a psycho- logical underlay.Night sweats, sometimes most profuse and disturbing, are common enough during the puerperium and early weeks of lactation, and in the absence of pyrexia they are not of any real significance.Persistence of red lochial discharge for six weeks after delivery is also not necessarily pathological.Cyclical ulceration of the mouth associated with menstruation and perhaps causing discomfort in the gums is a condition the cause of which is unknown.It may be an allergic manifesta- tion, and is dealt with at some length in replies to questions in
NIMG-13. RADIOLOGICAL RESPONSE ASSESSMENT IN THE ERA OF BEVACIZUMAB: RANO OR VOLUMETRY? A REPORT FROM THE BELOB TRIAL
Authors: Renske Gahrmann, Martin van den Bent, B. van der Holt, R. Vernhout, W. Taal, Martin Taphoorn, J.C. de Groot, L. Beerepoot, J. Buter, Z. Flach, M. Hanse, B. Jasperse, Marion Smits
Journal: Neuro-Oncology (2016)

To determine whether volumetric methods are preferable to the 2D RANO-criteria for assessing treatment response in bevacizumab-treated recurrent glioblastoma. Patients with MRI-data from the BELOB-trial (n=148), treated with lomustine (CCNU) and/or bevacizumab, were included. Progressive disease (PD) was determined with 1.RANO and 4 volumetric methods: 2.enhancing volume (T1w+C), 3.subtracted enhancing volume (T1w+C minus pre-contrast T1w), 4.enhancing plus FLAIR-volume, and 5.subtracted enhancing plus FLAIR-volume. Volumetric PD was defined as ≥40% increase in enhancing/subtracted volume, ≥25% increase in FLAIR-volume, or new lesions. RANO assessment was performed by 2 experienced raters; volumetric analysis by a single observer. At 6 and 12 weeks follow-up (FU1, FU2), differences in overall survival (OS) for PD versus non-PD per method were assessed with the log-rank test and cox-model. Hazard ratios (HR) with 95% confidence interval (CI) were analyzed in all patients together and per treatment group (CCNU or bevacizumab+/-CCNU). Results were considered valid if posthoc power was >.80. For all patients together at FU1 and FU2, all methods, except method 3 at FU1, showed significant differences in OS between PD and non-PD (p<.001). The largest HR was found with method 1 at both FU1 and FU2: respectively 2.81(95% CI,1.92-4.10) and 2.80(1.75-4.49). The CCNU-group was excluded from further analysis (power<.80). In the bevacizumab-group, analyses were valid for methods 1,2,4 and 5 at FU1 and methods 1 and 4 at FU2. All showed significant differences in OS between PD and non-PD. At FU1, the largest HR was found with method 2: 7.21(3.20-16.2). At FU2 the HR for methods 1 and 4 were respectively 2.44(1.46-4.08) and 2.35(1.32-4.19). No significant differences between methods were found in any of the analyses. Our results indicate that volumetric and subtraction methods are not superior for response evaluation of recurrent glioblastoma (treated with bevacizumab) compared to RANO.
ARTERIOSCLEROSIS
Authors: Louis M. Warfield
Journal: JAMA (1926)

<h3>To the Editor:</h3> —After careful reading of the papers inThe Journal, Nov. 28, 1925, by those who took part in the symposium on vascular and renal disease at the Atlantic City session, I am confused as to the definition of the term arteriosclerosis, so frequently used. Apparently the authors do not all use this word in the same sense. The criteria for diagnosis are clinical, obtained by palpating the available superficial arteries and by measuring the blood pressure. The theories, however closely reasoned and deduced from observation, are nevertheless based on individual opinion of the thickness of palpable arteries and the course of the patients' condition under various forms of treatment. These are well recognized methods of clinical research, yet they are open to considerable objection and can hardly be used to develop anything more than a pure theory. It is not my intention to develop a theory but
Back Pain: The History and Physical Examination
Authors: Bruce M. Rothschild
Journal: JAMA (1993)

<h3>To the Editor.</h3> —Given the scope of the article by Deyo et al,<sup>1</sup>I was surprised that the authors did not discuss fibromyalgia. It may well be the most common cause of low back pain and is identifiable by notation of typical tender "trigger" points.<sup>2</sup>Pressure, manually applied to specific sites, identifies the presence of such "trigger areas." These sites include the temporalis (above the ear), anterior to the tragus of the ear, scalenus capitis, sternocleidomastoid, low anterior neck, pectoralis minor, manubrium of sternum, anterior and posterior axillary folds, low posterior neck, trapezius ridge, upper and lower rhomboids, parasagittal thoracolumbar spine, iliac crest, mid buttocks, mid vastus lateralis, and the quadriceps insertion at the patella. While trigger points are not necessarily limited to the low back, low back pain is often the presenting complaint. The pain is often modulated by physical activity, weather changes, anxiety, and stress. It
Treatment cascade of hepatitis C in a non-university hospital setting, that uses a hub-and-spoke model, in southern Switzerland
Authors: Adriana Baserga, Benedetta Terziroli, Lorenzo Magenta, Antonella Robatto, Manuela Balmelli, Alberto Moriggia, Daniel Hagara, Odile Stadler, Sheila Appadoo, Andrea De Gottardi, Andreas Cerny
Journal: Journal of Hepatology (2020)
Acute and late toxicity in high-risk prostate cancer patients treated with androgen suppression and hypofractionated pelvic radiotherapy.
Authors: Sergio Faria, Russel RUO, Fabio Cury, Marie Duclos, Luis Souhami
Journal: Journal of Clinical Oncology (2017)

47 Background: Two recent large randomized trials confirm that 60Gy in 20 fractions is an effective regimen compared to conventionally fractionated escalated doses in localized prostate cancer. However, in these two trials the prostate was the only target volume irradiated. The purpose of this study is to report acute and late toxicity in patients with high-risk prostate cancer treated with the same moderate hypofractionated radiotherapy (HypoRT) to two target volumes at the same time: prostate and pelvic nodes. Methods: High-risk prostate cancer patients received 60Gy/20 fractions (4 weeks) to the prostate while the pelvic-nodes received 44Gy delivered with intensity modulated radiation therapy (IMRT) with a simultaneous integrated boost (SIB) during the same 20 fractions. ADT started 2-3 months before HypoRT. Acute and late toxicity were prospectively assessed according to CTCAE.v3. Results: 105 patients treated between September/2010 and November/2013 were reviewed. Median follow up is 41 months. Median ADT duration was 18 months. Acute grade &gt; 2 gastrointestinal (GI) or genitourinary (GU) toxicity was seen in 17% and 17% respectively, with only 1 and 3 patients experiencing GI and GU acute grade 3 toxicity, respectively. The worst grade &gt; 2 late GI and GU toxicity was seen in 7% and 8% of patients, respectively. There was no grade 4-5 toxicity. At the last follow-up, the rates of grade = 2 GI and GU toxicity were 5% and 3%, respectively with no residual grade &gt; 3 toxicity. The 48-month actuarial progression free survival is 82%. We found only 8 publications on this topic, all delivered the HypoRT in 25-28 fractions, but only one has long-term toxicity. Conclusions: ADT with HypoRT delivered with IMRT and SIB to the prostate (60Gy) and pelvic nodes (44Gy) in 20 fractions is feasible and well tolerated after 41months of median follow-up. Our approach shortens treatment duration, is convenient and its results support a needed randomized trial. Clinical trial information: NCT02107287.
American Journal of Medical Sciences, Philadelphia
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
"A COURT OF DECENCY FOR PHYSICIANS"
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Kindlin-3–mediated signaling from multiple integrin classes is required for osteoclast-mediated bone resorption
Authors: Sarah Schmidt, Inaam Nakchbandi, Raphael Ruppert, Nina Kawelke, Michael W. Hess, Kristian Pfaller, Pierre Jurdic, Reinhard Fässler, Markus Moser
Journal: The Journal of Experimental Medicine (2011)
Scientific exhibits
Authors: Robert Reinecke, Paul Lichter, Ann Arbor, David Worthen, Charles Koester, Calvin Roberts, Anthony Donn, Frank Hoeffe, New York, John Cowden, Clifford Harding, Karni Frank, Stanley Susan, Frederick Brightbill, Gary Mackman, Christopher Larson, Frank Myers, George Bresnick
Journal: Ophthalmology (1979)
Heat-Related Deaths—Dallas, Wichita, and Cooke Counties, Texas, and United States, 1996
Journal: JAMA (1997)

During July 2-8, 1996, high maximum daily temperatures in Dallas County, Texas, ranged from 101 F (38.3 C) to 106 F (41.1 C), and high maximum daily heat indexes (a measure of the effect of combined elements [e.g., heat and humidity] on the body) ranged from 105 F (40.6 C) to 112 F (44.4 C). Although guidelines for issuing heat advisories or warnings vary by geographic location and climate, the National Weather Service generally suggests issuing a heat advisory when a daytime heat index reaches > or =105 F (> or =40.6 C), and a night time minimum ambient temperature of 80 F (26.7 C) persists for at least 48 hours. In Dallas County, the criterion used by the medical examiner's (ME's) office to designate a heat wave is > or =3 consecutive days of temperatures > or =100 F (37.8 C). This report describes four cases of heat-related death in Dallas, Wichita, and Cooke counties, Texas, in 1996; summarizes risk factors for this problem; and reviews measures to prevent heat-related morbidity and mortality. The findings in this report indicate that, although a large proportion of heat-related deaths occur during the summer and during heat waves, such deaths occur year-round.
Dying
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Trends in Cholesterol Screening and Awareness of High Blood Cholesterol--United States, 1991-2003
Journal: JAMA (2005)

High blood cholesterol (HBC) (i.e., total cholesterol > or =240 mg/dL) is a major risk factor for heart disease, the leading cause of death in the United States. As a result, public health agencies and their partners have attempted to reduce the prevalence of HBC through screening and by increasing public awareness of HBC and strategies for reducing it. A national health objectives of Healthy People 2010 is to increase to 80% the proportion of adults aged > or =20 years who have been screened for HBC within the preceding 5 years. For this report, data from the Behavioral Risk Factor Surveillance System (BRFSS) collected during 1991-2003 were analyzed to examine trends in the percentage of adults screened for HBC and the percentage of those screened who were told they had HBC. The findings indicated that both percentages increased during 1991-2003 but that few states had achieved the national health objective for screening. Further emphasis on cholesterol screening is needed, particularly among Hispanic and Asian/Pacific Islander populations and young adults.