tbuckley/cabot-search huggingface dataset:
"Chronic ataluren (PTC124) treatment of nonsense mutation cystic fibrosis." M. Wilschanski, L.L. Miller, D. Shoseyov, H. Blau, J. Rivlin, M. Aviram, M. Cohen, S. Armoni, Y. Yaakov, T. Pugatch, M. Cohen-Cymberknoh, N.L. Miller, A. Reha, V.J. Northcutt, S. Hirawat, K. Donnelly, G.L. Elfring, T. Ajayi and E. Kerem. Eur Respir J 2011; 38: 59-69.
Authors: M Wilschanski, L Miller, D Shoseyov, H Blau, J Rivlin, M Aviram, M Cohen, S Armoni, Y Yaakov, T Pugatch, M Cohen-Cymberknoh, N Miller, A Reha, V Northcutt, S Hirawat, K Donnelly, G Elfring, T Ajayi, E Kerem
Journal: European Respiratory Journal (2011)
Books Received
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
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Authors: GEORGE W. BARTELMEZ
Journal: JAMA (1941)

In the human species, menstruation is the only overt manifestation of rhythm in the female reproductive system. In other primates there may be additional and even more obvious indications of cyclic changes. Corner<sup>1d</sup>and Edgar Allen<sup>1e</sup>have recently summarized the evidence that the rhythm is maintained by a delicate balance of endocrines. We are not dealing with "an all or none" phenomenon but with a balanced system of forces which changes as a whole when any one factor changes. The oscillations of the system may have a high amplitude or they may become almost imperceptible. The system is accordingly variable in its manifestations. This is generally conceded; the difference of opinion is largely a matter of the range of variability that is to be regarded as normal. Many clinicians are unwilling to regard a cycle as normal unless its primary purpose is achieved; i. e., unless a fertilizable
Association News.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Therapeutic Abortion
Authors: Thomas G. Wygant
Journal: JAMA (1966)

<h3>To the Editor:—</h3> I feel that the author of "Changing Attitudes Toward Therapeutic Abortion" (<b>196</b>:1140, 1966) has stepped outside the bounds of his purpose in the section under Comment. This portion of the paper admits to a great deal of tragedy and despair involved in spurious pregnancy and that which is associated with criminal rape. The tragedy and despair are an ever present part of human life and the examples given though they may deserve sympathy hardly warrent intervention by therapeutic abortion. In the article intervention is all too easily defined as therapeutic abortion which is a sterile term and ignores entirely the right to life possessed by the unborn child. This philosophy is Thomistic and well may be at variance with the author's. Still, it seems improper that the medical profession could allow itself to become the scapegoat of those suffering the social stigmata of spurious pregnancy and
The investigation of dysphagia
Journal: JAMA (1986)

<h3>To the Editor.—</h3> Kathryn Simmons<sup>1</sup>presented a valuable discussion of dysphagia management in the June 20th issue of<i>JAMA</i>, describing problems of this nature stemming from such conditions as bulbar neurological disease, Alzheimer's disease, amyotrophic lateral sclerosis, hyperthyroidism, retropharyngeal abscesses, and myasthenia gravis. However, when Martin Donner, MD, states that "the mystique of 'globus hystericus'—that somebody is hysterical and therefore can't swallow—is to a large extent nonexistent," I must challenge this conclusion. Idiomatic expressions such as "I can't swallow that" or "I can't stomach that" or "Hearing that makes me sick" did not evolve from outer space. Human beings recognized that bodily functions may echo emotions. Having been psychiatric consultant to the allergy and immunology clinic and to the family medicine department at the UCLA Medical Center, Los Angeles, for many years as well as being in private practice for over 30 years, I have encountered a number of
Intracaval endovascular ultrasonography for preoperative assessment of retrohepatic inferior vena cava infiltration by malignant hepatic tumors
Authors: T Kaneko, A Nakao, S Nomoto, T Endo, S Itoh, H Takagi
Journal: Hepatology (1996)

The accurate diagnosis of inferior vena cava infiltration is important not only for preoperative staging but also for performing surgery for hepatic tumor involving the inferior vena cava (IVC). We investigated the diagnostic value of intracaval endovascular ultrasonography (ICEUS) in the diagnosis of invasion of the IVC by a prospective study of 30 consecutive patients with hepatic tumors with possible invasion of the IVC. The procedure was performed using an 8F, 20–MHz intravascular ultrasonography (US) from the right femoral vein. Twenty–nine of the 30 patients underwent surgery, and the tumor was resected in 25 cases, including 3 cases of combined resection of the IVC. The diagnostic criterion for IVC infiltration with ICEUS was obliteration of a single echogenic layer of the IVC wall or intracaval tumor mass. The results of ICEUS were compared with those of computed tomography (CT), cavography, conventional US, and intraoperative US. Vascular invasion was identified in 7 of 30 cases and was subsequently confirmed by pathological examination of four resected specimens, including one autopsy and two operative findings. The sensitivity, specificity, and overall accuracy of ICEUS for the diagnosis of the IVC invasion was 100%, 95.8%, and 96.7%, respectively, against 85.7%, 60.8%, and 66.7% for CT, and 71.4%, 73.9%, and 73.3%, respectively, for cavography. The sensitivity, specificity, and overall accuracy of conventional US was 87.5%, 59%, and 66.7%, respectively; those of intraoperative US were 100%, 81.8%, and 86.2%, respectively. ICEUS is a useful technique that can precisely evaluate the IVC for possible hepatic tumor invasion.
The History of Yellow Fever in West Africa
Authors: R. Boyce
Journal: BMJ (1911)

MEDICAL JOURNAL24ness, and a definite edge could be felt to descend during inspiration.Elsewhere there was no abnormal tenderness or mass.There were no signs of tuberole to be found in other parts of the body.Shortly afterwards an indefinite tender mass made its appear- ance in the epigastrium, its lower border corresponding with the sharp edge previously noticed.During the first fortnight there was a slight nocturnal rise of temperature, but afterwards this subsided and remained normal.As the condition was considered to be one of abdominal tubercle, the ordinary hygienic treatment was adopted, and, throughout his stay in hospital (about three months), he slowly and, steadily gained weight and lost all symptoms.He was eventually sent to a
Active surveillance in metastatic renal cell carcinoma (mRCC): Results from the Canadian Kidney Cancer information system (CKCis).
Authors: Igal Kushnir, Naveen S. Basappa, Sunita Ghosh, Aly-Khan A. Lalani, Denis Soulieres, Georg A. Bjarnason, Lori Wood, David Dawe, Christian K. Kollmannsberger, Daniel Yick Chin Heng, Anil Kapoor, Aaron Richard Hansen, Frederic Pouliot, M. Neil Reaume
Journal: Journal of Clinical Oncology (2019)

4516 Background: Active surveillance (AS) is a commonly used strategy in patients (pts) with low tumor burden or slow growing disease. However, few studies have assessed AS for mRCC compared to immediate treatment. We aimed to assess the outcomes and safety of AS in comparison to immediate systemic treatment for mRCC pts. Methods: Using CKCis, mRCC pts diagnosed between January 1, 2011 and December 31, 2016 were identified. AS strategy was defined as: (1) start of systemic therapy ≥6 months after diagnosis of mRCC; or (2) never receiving systemic therapy for mRCC with an overall survival (OS) ≥1 yr (OS ≥ 1 yr a surrogate to exclude pts not started on treatment due to poor prognosis). Pts starting systemic treatment &lt; 6 months after diagnosis of mRCC were defined as receiving immediate systemic treatment. OS and time until 1 st line treatment failure (TTF) between the two cohorts were compared. Results: A total of 863 pts met criteria for AS (cohort A). Of these, 370 started treatment ≥ 6 months after their initial diagnosis (cohort A1) and 493 never received systemic treatment and were alive for ≥1 year (cohort A2). 848 pts received immediate systemic treatment (cohort B). Median age for pts in cohort A and B was 65.1 (19.0-91.5) vs. 62.2 yrs (23.1-87.1) (p &lt; 0.0001). Sex distribution was not statistically different. Pts in cohort A had fewer sites of metastatic disease vs. cohort B ( &lt; 0.0001) and 23% of pts in cohort A had metastasectomy vs. 5% in cohort B (P = &lt; 0.0001). Five-year OS probability was significantly greater for cohort A than for cohort B (70.2% vs. 32.1%; P &lt; 0.0001). After adjusting for IMDC risk criteria and age, both OS (HR 0.46, 0.38-0.56, P &lt; 0.0001) and TTF (HR 0.79, 0.69-0.92, P = 0.0021) were greater in cohort A1 vs. B. For cohort A1 the median time on AS was 14.2 m (range 6 – 71). Conclusions: Based on the largest analysis of AS in mRCC to date, our data suggest that a subset of pts may be safely observed without immediate initiation of systemic therapy. Prospective validation is required in the contemporary immunotherapy era.
Measles
Authors: Jonathan M Keller, Charles S. Dela Cruz, Susan Pasnick, Jane E. Gross, W. Graham Carlos, Ryan Maves, Shazia Jamil
Journal: American Journal of Respiratory and Critical Care Medicine (2019)

How is measles spread?Measles is spread from person to person.The virus enters your body through the eyes, nose, or mouth.You can get sick by being exposed to an infected person who is coughing, sneezing, or from secretions on their hands.The virus can also live up to 2 hours on surfaces and in contaminated air spaces.Measles is highly contagious: up to 90% of people who have not had vaccine and who come in close contact with an infected person will develop the disease.Symptoms start within 7-14 days of exposure.In comparison, only about 25% of the people living in the same home as a person with influenza will contract the flu themselves.
PDTM-21. MATCHING OF SINGLE CELL TRANSCRIPTOMICS FROM CEREBELLAR DEVELOPMENT IDENTIFIES PUTATIVE SUBGROUP SPECIFIC CELLS OF ORIGIN FOR MEDULLOBLASTOMA
Authors: Ibrahim El-Hamamy, Maria Vladoiu, Laura Donovan, Florence Cavalli, Vijay Ramaswamy, Hamza Farooq, Borja Lopez, Claudia Kleinman, Jennifer Chan, Sheila Singh, Nada Jabado, Lincoln Stein, Michael Taylor
Journal: Neuro-Oncology (2018)

We isolated cells from various points in murine embryonic and early post-natal cerebellar development (E10 to P14) and undertook single cell RNA sequencing to identify >30 transcriptionally distinct cell populations. Reconstruction of developmental lineages in the developing cerebellum through pseudotemporal analysis demonstrate that a progenitor cell population from the upper rhombic lip gives rise to both the external granule cell layer (EGL) and the previously under-studied unipolar brush cells (UBC). Unipolar brush cells are a glutamatergic interneuron most prevalent in the inferior and lateral cerebellum. Transcriptional matching of bulk human tumor RNA-seq data from human patients demonstrates subgroup specific transcriptional resemblances. As expected, Shh MBs resemble the developing EGL. Fascinatingly, only Shh tumors that transcriptionally mirror earlier, but not later EGL developmental time points were found to be metastatic in human patients. Group 3 tumors have a resemblance to early Nestin +ve stem cells across the entire subgroup, with additional similarities to the EGL, UBC, and GABAergic interneurons. Unexpectedly, Group 4 tumors were vastly most similar to UBCs, and on further analysis to a single known subset of UBCs (Calb2+ve UBCs). Single cell RNA-seq from human medulloblastomas (Shh, Group 3, and Group 4 MB) largely confirms the transcriptional similarities to murine cerebellar developmental lineages observed in the bulk RNA-seq data, but also demonstrates that most medulloblastomas have multiple distinct tumor cell clusters. Distinct single cell expression clusters from an individual MB demonstrate that there is a developmental lineage or hierarchy of cells with most tumors, that this hierarchy is likely hardwired from normal development, and that bulk tumor data in fact reflects a heterogeneous cell population. These data pinpoint possible cells of origin for medulloblastoma subgroups, illustrate a further layer of MB heterogeneity, and allow a comparison of normal and MB transcriptomes to further understand MB biology.
Abstract 18756: Focal Impulse and Rotor Mapping (FIRM): Analysis of Basket Electrode-endocardial Proximity
Authors: Siva Kumar R Soma, Donald R Siddoway, Raveen Bazaz, Andrew Voigt, Sandeep Jain, Samir Saba, David Schwartzman
Journal: Circulation (2015)

Introduction/Hypothesis: Reports of outcomes of atrial fibrillation (AF) ablation guided by FIRM have thus far been promising. FIRM maps are derived from atrial electrograms acquired using a 64 electrode “basket” catheter. There are significant discrepancies between atrial endocardial and basket geometries, and we sought to analyze individual basket electrode-endocardial proximities. Methods: In 13 patients with persistent AF undergoing FIRM-guided ablation, extensive fast anatomical mapping of right (RA, N=10) and/or left (LA, N=9) atria using the CARTO™ system (Biosense) yielded comprehensive, high quality endocardial geometries. Basket location projected within these geometries permitted assessment of endocardial proximity of each basket electrode. Proximity was defined as “near” (within 5 mm of nearest endocardial surface), “distant” (5-10 mm), and “very distant” (&gt;10 mm). In analyzing proximity status of groups of electrodes which comprised observed rotors, “uniform near” was defined as all electrodes within 5 mm of endocardium, “mixed” was defined as some electrodes within 5 mm and others beyond 5 mm, and “uniform far” as all electrodes beyond 5 mm. Results: Right atrium: Among 10 patients, 54% of electrodes were near, 22% of electrodes were distant, and 24% of electrodes were very distant. Among 15 discrete rotors observed in 7 patients, 6 (40%) were uniform near, 8 (53%) were mixed, and 1 (7%) was uniform far. Left Atrium: Among 9 patients, 53% of electrodes were near, 24% of electrodes were distant, and 23% of electrodes were very distant. Among 17 discrete rotors observed in 9 patients, 8 (47%) were uniform near, 9 (53%) were mixed, and none were uniform far. Conclusions: Electrodes used to construct FIRM maps are commonly distant from the endocardial surface. Contact heterogeneity is common among groups of electrodes comprising rotors. The implications of these observations for use and utility of the basket-derived FIRM technique are unclear.
MAHLON LOCKE—FOOT TWISTER EXTRAORDINARY
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diffuse colitis with right upper quadrant mass
Authors: L. S. Rosenberg
Journal: JAMA (1978)

<h3>History</h3> A 37-year-old woman was admitted to the hospital because of recent generalized myalgia, fever, and abdominal pain. There was a history of chronic diarrhea for at least three years, with four to six liquid brownish stools per day, without gross blood. Palpation of the abdomen demonstrated considerable tenderness throughout the right side. Rectal examination was painful. There was occult blood (1+) in the stool. The temperature on admission was 38 °C; the hemoglobin level, 6.5 g; and the WBC count, 20,000/cu mm. A plain film of the abdomen (Fig 1) and a diatrizoate (Hypaque) enema examination (Fig 2) were obtained. On the following day, the patient's symptoms became worse and more localized to the right upper quadrant of the abdomen. The temperature rose to 39 °C. <h3>Diagnosis</h3> Diffuse amebic colitis with ruptured amebic abscess of the liver. The plain film (Fig 1) demonstrates gaseous distension of small-bowel loops in
The association of age with acute toxicities in NRG oncology combined modality lower GI cancer trials.
Authors: Noam Avraham VanderWalde, Jennifer Moughan, Stuart M. Lichtman, Reshma Jagsi, Matthew T. Ballo, Ari M. Vanderwalde, Mohammed Mohiuddin, Neal J. Meropol, Lisa A. Kachnic, Michael C. Garofalo, Jaffer A. Ajani, Robert W. Beart, Rani Anne, Lisa Smith Evans, Amit Arora, Joshua E. Meyer, James J. Lee, John A. Keech, Gamini S. Soori, Christopher H. Crane
Journal: Journal of Clinical Oncology (2019)

649 Background: This study sought to compare adverse events (AEs) of older and younger adults with lower gastrointestinal (GI) malignancies treated on NRG studies. Methods: Data from six NRG trials (RTOG 9811/0012/0247/0529/0822 &amp; NSABP R-04), testing combined modality therapy (radiation and chemotherapy) in patients with anal or rectal cancer, were collected to test the hypothesis that older age was associated with increase in acute ( ≤ 90 days from treatment start) AEs. AEs were defined as GI, Genitourinary (GU), hematologic, or skin. AEs and compliance with protocol-directed therapy were compared between patients aged ≥ 70 years and &lt; 70 years. Categorical variables were compared across age groups using the chi-square test. The association of age on AEs was evaluated using a covariate-adjusted logistic regression model, with odds ratio (OR) reported. To adjust for multiple comparisons, a p-value &lt; 0.01 was considered statistically significant. Results: Data from 2525 patients were collected (43% female, 72% rectal cancer). There were 380 patients ≥ 70 years old (15%). Older patients were more likely to have worse baseline performance status (PS 1 or 2) (23% vs. 16%, p &lt;0.01), but otherwise baseline characteristics were similar. Older patients were less likely to have completed their chemotherapy (78% vs. 87%, p &lt; 0.01), but had similar median RT duration. On univariate analysis, patients ≥ 70 were more likely to experience grade ≥ 3 GI AEs (36% vs. 23%, OR 1.82, p &lt; 0.001), and less likely to experience ≥ 3 skin AEs (8% vs. 14%, OR 0.56, p = 0.002). There was no difference between GU or hematologic AEs. On multivariable analysis, age ≥ 70 was associated with grade ≥ 3 GI AE (OR 1.80, 95% CI: 1.40, 2.31; p &lt; 0.001) after adjusting for gender, PS, T stage, disease site, RT duration, and chemotherapy completion. Conclusions: Older patients with curable lower GI cancers who underwent combined-modality therapy were less likely to complete chemotherapy and were more likely to experience serious GI toxicity, whereas younger patients had higher rates of serious skin AEs.
Surgery promising in sclerosing cholangitis
Authors: P. Gunby
Journal: JAMA (1983)

Like many physicians who treat liver disease, surgeon John L. Cameron, MD, and internist Willis C. Maddrey, MD, have long been concerned with the lack of specific therapy for patients with sclerosing cholangitis. Multiple strictures and small fibrotic ducts characterize this chronic inflammatory disease and have complicated attempts to treat it by surgery. Then, three years ago, while reviewing cholangiograms of patients who had come to Johns Hopkins University School of Medicine in Baltimore for treatment of the condition, the two investigators noted that often the most narrowed area was at the bifurcation of the hepatic duct. They began to work on a surgical strategy, preliminary results of which were reported at the meeting of the American Association for the Study of Liver Diseases (of which Maddrey is president) in Chicago. The strategy involves resecting the hepatic duct bifurcation, gently stretching the left and right hepatic ducts with a metal
Table Errors
Journal: JAMA (1982)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal