tbuckley/cabot-search huggingface dataset:
ELEVENTH ANNUAL SUMMARY OF FOURTH OF JULY INJURIES
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Random allocation II
Authors: P. Sedgwick
Journal: BMJ (2009)

A randomised, single blind, controlled trial investigated whether knee tape reduced pain and disability for patients with osteoarthritis of the knee.1 The trial had three intervention arms: therapeutic tape, control tape, and no tape. A total of 87 patients were recruited from an outpatient clinic. Allocation to an intervention was undertaken using groups of three consecutive patients. Within each group of three patients, each individual received a different intervention and the order in which the interventions were allocated was random. Which one of the following statements best describes the method by which patients were allocated to an intervention?
"Opportunistic" Infections.
Authors: W. St. Clair Symmers
Journal: Annals of Internal Medicine (1968)

s1 May 1968"Opportunistic" Infections.W. St. Clair Symmers, M.D., F.R.C.P.W. St. Clair Symmers, M.D., F.R.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-68-5-1177_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAn infection may be described as "opportunistic" if it develops as a result of disease or therapy interfering with the body's resistance. Opportunistic infections are usually severe, with hematogenic dissemination and a high mortality. Many of the organisms concerned have little or no pathogenicity in ordinary circumstances; some are familiar pathogens. Among the organisms in the author's series were bacteria (for example, various gram-negative bacilli, Staphylococcus albus, Mima, commensal corynebacteria, lactobacilli), fungi (for example, Candida, Geotrichum, Torulopsis, Trichophyton, Aspergillus, Penicillium, Rhizopus), viruses (herpes simplex, cytomegalovirus, varicella-zoster), and protozoa (Pneumocystis, Toxoplasma). Multiple infections are frequent.Litle has been learned of the... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: London, PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1968Volume 68, Issue 5Page: 1177-1177KeywordsBacteriaCandidaFungal pathogensHerpes simplexInfectious diseasesMortalityOpportunistic infectionsPneumocystisStaphylococcusToxoplasma Issue Published: 1 May 1968 PDF downloadLoading ...
398PD PD-L1 status in Taiwanese lung adenocarcinoma patients: Comparison of PD-L1 immunohistochemical assays using antibody clones 22C3, SP142 and SP263 with clinicopathological correlation
Authors: Y.-C. Yeh, S.-F. Lin, C.-H. Chiu, Y.-C. Wu, W.-Y. Hsieh, H.-L. Ho, T.-Y. Chou
Journal: Annals of Oncology (2016)
PD-1/PD-1-Ligand Interaction Contributes to Immunosuppressive Microenvironment of Hodgkin Lymphoma.
Authors: Ryo Yamamoto, Momoko Nishikori, Toshio Kitawaki, Tomomi Sakai, Masakatsu Hishizawa, Masaharu Tashima, Tadakazu Kondo, Katsuyuki Ohmori, Takashi Uchiyama
Journal: Blood (2007)
Parietal Attentional System Aberrations During Target Detection in Adolescents With Attention Deficit Hyperactivity Disorder: Event-Related fMRI Evidence
Authors: Leanne Tamm
Journal: American Journal of Psychiatry (2006)

Objective: Directed attention, the ability to allocate and direct attention toward a salient stimulus, is impaired in attention deficit hyperactivity disorder (ADHD). This construct is often assessed with target detection or oddball tasks, and individuals with ADHD perform poorly on such tasks. However, to date, the specific brain structures or neural mechanisms underlying target detection dysfunction in individuals with ADHD have not been identified. The authors' goal was to investigate neural correlates of target detection dysfunction in ADHD using event-related fMRI. Method: Behavioral and brain activation data were collected while subjects performed a visual oddball task. Participants included 14 right-handed male adolescents with ADHD (combined type) and 12 typically developing age- and handedness-matched male comparison subjects. Results: Individuals with ADHD made significantly more errors of commission than comparison subjects. Further, relative to comparison subjects, individuals with ADHD showed significantly less activation in the bilateral parietal lobes (including the superior parietal gyrus and supramarginal and angular gyri of the inferior parietal lobe), right precuneus, and thalamus. Conclusions: Adolescents with ADHD demonstrated significant impairments in their ability to direct and allocate attentional resources. These difficulties were associated with significant aberrations in the parietal attentional system, which is known to play a significant role in attention shifting and detecting specific or salient targets. Thus, dysfunction in the parietal attentional system may play a significant role in the behavioral phenotype of ADHD.
Should we screen for coeliac disease? Yes
Authors: A. Fasano
Journal: BMJ (2009)

<h3>Abstract</h3> The structure and composition of the bronchial epithelium is altered in respiratory diseases such as COPD and asthma, in which goblet cell hyperplasia and reduced numbers of ciliated cells impair mucociliary clearance. We describe a robust genome editing pipeline to interrogate modulators of primary human bronchial epithelial cell (HBEC) differentiation and function. By employing plasmid- and virus-free delivery of CRISPR/Cas9 to human airway basal cells we achieve highly efficient gene inactivation without the need for positive selection. Genome edited cells are differentiated at air liquid interface (ALI) into a pseudo-stratified epithelium. We focus on profiling ciliation using imaging cytometry coupled to confocal microscopy and immunohistochemistry. To our knowledge, this is the first study to describe highly efficient genome editing of ALI cultured primary HBECs. As proof of concept, we establish that inactivation of the gene encoding the transcription factor FOXJ1 in primary human airway basal cells precludes ciliation in ALI differentiated bronchial epithelia.
Instructions to Authors
Journal: Cardiovascular Research (2002)

Cardiovascular Research is the International Basic Science Journal of the regular paper, but add (Abstract) at end.If the bibliography contains more European Society of Cardiology.The Journal is concerned with both than six authors, et al. should be added following the third author.basic and clinical research in the field of cardiovascular physiology and (10) Figures / Tables.Figures should be original laser prints or very pathophysiology.The Journal welcomes submission of papers both at the sharp, well-contrasting prints on glossy paper, suitable for immediate molecular, subcellular, cellular, organ and organism level and of clinically reproduction.Half-tone figures should be in black-and-white, very sharp, oriented papers offering insight into (patho)physiological mechanisms.well-contrasting, and on glossy paper.Any lettering in the figures should Manuscripts may be submitted as Regular Papers or as Letters to the be large enough to stand photographic reduction.Contributors should Editor.Moreover the Journal publishes Reviews and Editorials.Manu-prepare their figures for either one column width (84 mm) or the entire scripts are normally evaluated by three members from an international page width (175 mm).The maximum height is 240
Hypertensive Heartbreak
Authors: Emily S. Lau, Benjamin Scirica, Inga-Marie Schaefer, Amy L. Miller, Joseph Loscalzo
Journal: New England Journal of Medicine (2021)

A 61-year-old man with chronic knee pain was evaluated for elective total knee arthroplasty. During the preoperative visit, his blood pressure was 178/92 mm Hg. On day 1 after surgery, during physical therapy, his blood pressure increased to 216/99 mm Hg, with a heart rate of 141 beats per minute. The article is accompanied by a video.
Dysesthesia, witchcraft, and conversion reaction. A case successfully treated with psychotherapy
Authors: J. R. Hillard
Journal: JAMA (1978)

An intelligent, well-educated black woman from the rural South, through an interaction of psychopathology and cultural background, experienced dysesthesia as a conversion reaction and came to believe that she was the victim of witchcraft. After neurological evaluation showed no abnormalities, she was successfully treated with conventional psychotherapy. Belief in hexing or root work is still alive today and should be inquired about in patients with unusual symptoms and an appropriate cultural background. (<i>JAMA</i>240:1742-1744, 1978)
JOHANN FRIEDRICH MECKEL (1724-1774) FATHER OF THE DYNASTY
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hemoglobinemia and the Hemoglobinurias
Authors: Joseph F. Ross
Journal: New England Journal of Medicine (1945)

Paroxysmal Nocturnal HemoglobinuriaParoxysmal nocturnal hemoglobinuria, the strangest of this entire group of bizarre diseases, is also the most infrequent. Only 50 cases have been reported since Marchiafava and Nazari60 first recognized the condition as a separate disease entity in 1911. The disease usually appears during the third or fourth decade of life, although it has been described in a child of five and a half years61 and a woman aged fifty-two years.62 Of the reported cases, 25 have been males and 25 females. There is no demonstrable hereditary or familial tendency, and careful studies have failed to reveal predisposing . . .
The weight of pre-existing cofactors for liver disease progression in patients who successfully eradicated chronic hepatitis C viral infection: an interim analysis in the PITER cohort
Authors: Loreta Kondili, Maria Giovanna Quaranta, Monica Monti, Daniela Caterina Amoruso, Roberto Filomia, Elisa Biliotti, Andrea Iannone, Donatella Ieluzzi, Barbara Coco, Francesco Paolo Russo, Ilaria Beretta, Giustino Parruti, Pierluigi Blanc, Maria Vinci, Valentina Cossiga, Elisabetta Degasperi, Liliana Chemello, Marco Massari, Lorenzo Badia, Massimo Puoti, Serena Bruno, Martina De Siena, Valentina Panetta, Alessio Aghemo
Journal: Journal of Hepatology (2020)
Low Backache
Authors: D. Watson
Journal: BMJ (1955)

<h3>Abstract</h3> Three web-based calculators, and three analogous spreadsheets, have been generated that predict <i>in vivo</i> metal occupancies of proteins based on known metal affinities. The calculations exploit estimates of the availabilities of the labile buffered pools of different metals inside a cell. Here, metal availabilities have been estimated for a strain of <i>E. coli</i> that is commonly used in molecular biology and biochemistry research, for example in the production of recombinant proteins. Metal availabilities have been examined for cells grown in LB medium aerobically, anaerobically and in response to H<sub>2</sub>O<sub>2</sub> by monitoring the abundance of a selected set of metal-responsive transcripts by qPCR. The selected genes are regulated by DNA-binding metal sensors that have been thermodynamically characterised in related bacterial cells enabling gene expression to be read-out as a function of intracellular metal availabilities expressed as free energies for forming metal complexes. The calculators compare these values with the free energies for forming complexes with the protein of interest, derived from metal affinities, to estimate how effectively the protein can compete with exchangeable binding sites in the intracellular milieu. The calculators then inter-compete the different metals, limiting total occupancy of the site to a maximum stoichiometry of 1, to output percentage occupancies with each metal. In addition to making these new and conditional calculators available, an original purpose of this article was to provide a tutorial which discusses constraints of this approach and presents ways in which such calculators might be exploited in basic and applied research, and in next-generation manufacturing.
THE APPENDICES EPIPLOICÆ AS A CAUSE OF ABDOMINAL DISEASE.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AWARDS OF THE NOBEL PRIZES.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The second impact in catastrophic contact-sports head trauma
Authors: R. L. Saunders
Journal: JAMA (1984)

CATASTROPHIC brain injury following minor impact has been known to occur in contact sports, particularly football.<sup>1</sup>This peculiar susceptibility remains unexplained. However, the common resumption of contact play soon after concussion suggests that sequential minor impacts may occasionally lead to major cerebral pathological conditions. If these injuries have a compounding effect rather than representing isolated events, then additional impact to an already compliance-compromised brain might precipitate a catastrophic increase in intracranial pressure, perhaps through loss of vasomotor tone. We report a case documenting a preexisting cerebral contusion and the lethal effect of a second minor impact. This case suggests that clinical examination alone may sometimes be inadequate in evaluating persisting symptoms after minor head injury. In the athlete who has had a cerebral concussion, computed tomographic (CT) scanning may be required before medical clearance to resume play is justified. <h3>Report of a Case</h3> A 19-year-old, right-handed, college football player
Additional Cooperator
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Insulation in Leanness and Obesity
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 1510: Effects of the lung tumor microenvironment on T cell therapy
Authors: Leah Marie Schmidt, Oanh Tran, Cody Jenkins, Shannon Oda, Quintin Inman, Haley Leeper, Sasha Tan, Philip Greenberg
Journal: Cancer Research (2021)

Abstract Immune checkpoint therapy (ICT) is a front-line treatment for lung cancer; however, low mutational burden and ‘non-T cell inflamed' signatures predict poor responses to ICT in ~50% of patients. Adoptive cellular therapy (ACT) with T cells engineered to express T cell receptors (TCRs) specific for tumor-associated antigens (TAAs; proteins overexpressed by cancers) is an approach that circumvents the need for endogenous T cell responses. TCR-ACT is effective against hematologic cancers, but ACT against solid tumors is in the early stages of exploration. A deeper understanding of complex interactions between therapeutic cells and the tumor microenvironment (TME) is crucial for identifying successful strategies to enhance function and mitigate toxicity. Genetically engineered mouse models (GEMMs) achieve in situ tumor development alongside competent immune systems, recapitulating the native TME over the full spectrum of disease progression in a preclinical setting. KP GEMM lung tumors harbor few mutations, are poorly infiltrated by T cells, and are refractory to ICT, modeling intractable patient disease. We show that TAA-specific T cells recognize KP lung cancer cells and efficiently home to tumors, but rapidly lose function in the lung TME (compared to KP pancreatic tumors). Repetitive TCR-ACT can extend survival of animals with lung tumors, but animals eventually succumb to disease. These results show promise for TCR-ACT against lung cancer but highlight tissue-specific obstacles that must be overcome to enhance efficacy. Preliminary studies indicate that therapeutic T cells expressing immunomodulatory fusion proteins (IFPs) or accompanied by engineered helper T cells exhibit increased function in lung tumors, indicating that increased costimulatory signaling and T cell help can partially overcome T cell suppression in the lung TME. As we continue to leverage these models to advance our understanding of tissue-specific effects on therapeutic outcomes, these findings offer inroads to uncovering more effective therapies, with the ultimate goal of benefitting cancer patients. Citation Format: Leah Marie Schmidt, Oanh Tran, Cody Jenkins, Shannon Oda, Quintin Inman, Haley Leeper, Sasha Tan, Philip Greenberg. Effects of the lung tumor microenvironment on T cell therapy [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2021; 2021 Apr 10-15 and May 17-21. Philadelphia (PA): AACR; Cancer Res 2021;81(13_Suppl):Abstract nr 1510.