tbuckley/cabot-search huggingface dataset:
Phase II feasibility study of adjuvant S-1 plus docetaxel for stage III gastric cancer patients after curative D2 gastrectomy (OGSG 1002).
Authors: Jin Matsuyama, Kazumasa Fujitani, Shigeyuki Tamura, Yutaka Kimura, Hiroshi Imamura, Junya Fujita, Shohei Iijima, Shugo Ueda, Toshio Shimokawa, Yukinori Kurokawa, Taroh Satoh, Toshimasa Tsujinaka, Hiroshi Furukawa
Journal: Journal of Clinical Oncology (2014)

e15032 Background: An adjuvant chemotherapy with S-1 has become the standard treatment for patients (pts) with stage II/III gastric cancer (GC) in Japan. But, it is assumed that the survival benefit for stage III pts who received S-1 is modest. S-1 plus docetaxel has shown that the response rate and median overall survival (OS) were 56% and 14.3 months in pts with advanced GC. Our previous phase II study (OGSG0604), 4 cycles of S-1 plus docetaxel, had also showed good feasibility(78.8%). The aims of this phase II study were to evaluate the feasibility and safety of adjuvant S-1 plus docetaxel repeated for 6 months in pts with stage III GC who underwent D2 gastrectomy. Methods: Pts with pathological stage III GC who underwent D2 gastrectomy received oral S-1 (80 mg/m2/day) administration for consecutive 2 weeks and intravenous docetaxel (40 mg/m2) on day 1, repeated every 3 weeks (1 cycle). The treatment was started within 45 days after surgery, and repeated for 6 months, followed by S-1 administration until 1 year after surgery. The primary endpoint was feasibility of the 6 months administration of S-1 plus docetaxel; secondary endpoints were safety, PFS, OS and feasibility of S-1 administration. Sample size was set to be 60, which was determined to reject the feasibility of 50% under the expectation of 68% with power of 90% and two-sided α of 5%. Results: We enrolled 62 pts, 41 males and 21 females with a median age of 63.5 years (range, 30-79), between December 2010 and December 2012. Pathological stages included IIIA in 32 pts and IIIB in 30 pts. The feasibility of planned 6 months of treatment was 77.4% (95% CI 65.0-87.1%, P<0.001). Grade 4 neutropenia was observed in 19% of pts with no grade 3 or more febrile neutropenia. Non-hematological toxicities of grade 3 or more involved fatigue in 10%, anorexia in 18%, diarrhea in 2%, and nausea in 2%. No treatment-related deaths occurred. Conclusions: Adjuvant S-1 plus docetaxel therapy had good feasibility with moderate toxicities for stage III GC pts who have undergone D2 surgery. This regimen will be a candidate for future phase III trial seeking for the optimal adjuvant chemotherapy for stage III GC pts after D2 gastrectomy. Clinical trial information: UMIN000004440.
"The Atlanta Clinic"; Change of Management.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Progress Toward Poliomyelitis Eradication—Turkey, 1994-1997
Journal: JAMA (1998)

In 1989, as part of the global poliomyelitis eradication initiative, Turkey adopted the goal of eliminating polio by 2000; since then, substantial progress has been made toward achieving this objective. Turkey is a priority country for the global polio eradication initiative because of its large population (1996 population: 60 million), strategic location between Europe and Asia, and proximity to countries with endemic polio. This report summarizes progress during 1994-1997 in Turkey toward implementing the four polio eradication strategies recommended by the World Health Organization (WHO), reviews the cluster of polio cases in 1997, and suggests that recent poliovirus transmission might have resulted from suboptimal vaccination coverage in some areas of Turkey.
Characterization of Indoor Particle Sources: A Study Conducted in the Metropolitan Boston Area
Authors: Eileen Abt, Helen H. Suh, George Allen, Petros Koutrakis
Journal: Environmental Health Perspectives (2000)

An intensive particle monitoring study was conducted in homes in the Boston, Massachusetts, area during the winter and summer of 1996 in an effort to characterize sources of indoor particles. As part of this study, continuous particle size and mass concentration data were collected in four single-family homes, with each home monitored for one or two 6-day periods. Additionally, housing activity and air exchange rate data were collected. Cooking, cleaning, and the movement of people were identified as the most important indoor particle sources in these homes. These sources contributed significantly both to indoor concentrations (indoor-outdoor ratios varied between 2 and 33) and to altered indoor particle size distributions. Cooking, including broiling/baking, toasting, and barbecuing contributed primarily to particulate matter with physical diameters between 0.02 and 0.5 microm [PM((0.02-0.5))], with volume median diameters of between 0.13 and 0.25 microm. Sources of particulate matter with aerodynamic diameters between 0.7 and 10 microm [PM((0.7-10))] included sautéing, cleaning (vacuuming, dusting, and sweeping), and movement of people, with volume median diameters of between 3 and 4.3 microm. Frying was associated with particles from both PM((0.02-0.5)) and PM((0.7-10)). Air exchange rates ranged between 0.12 and 24.3 exchanges/hr and had significant impact on indoor particle levels and size distributions. Low air exchange rates (< 1 exchange/hr) resulted in longer air residence times and more time for particle concentrations from indoor sources to increase. When air exchange rates were higher (> 1 exchange/hr), the impact of indoor sources was less pronounced, as indoor particle concentrations tracked outdoor levels more closely.
Pediatrics.
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Infectious Diseases
Authors: R. Gordon Douglas
Journal: JAMA (1989)

Infectious diseases continue to be the focus of exciting new developments in detection of new infections, treatment and prevention of known diseases, and better understanding of their pathogenesis. In the past decade many new cephalosporins and penicillins have been introduced, as well as the new fluorinated quinolones. Some drugs offered significant pharmacokinetic advantages in addition to an expanded spectrum of activity, and the new quinolones offered, for the first time, oral therapy for serious gram-negative rod infections. One of the most exciting new agents is fluconazole, a new oral triazole antifungal agent that hopefully will be licensed soon. It is related to the imidazole, ketaconazole, but possesses significant advantages. It is well absorbed from the gastrointestinal tract and penetrates the blood-brain barrier so that cerebrospinal fluid levels are 70% to 80% of simultaneous blood levels. As a result of a serum half-life of 30 hours, once-a-day dosing is possible. It
Book Listings
Journal: Annals of Internal Medicine (2002)

Book Listings5 February 2002Book ListingsSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-136-3-200202050-00025 SectionsAboutFull Text ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Cardiology100 Questions in CardiologyD Holdright and H Montgomery, eds. 222 pages. London: BMJ; 2001. $42.00. ISBN 0727914898. Order phone 011-44-171-387-4499.ABC of Hypertension4th edition. G Beevers, GY Lip, and E O'Brien. 108 pages. London: BMJ; 2001. $25.00. ISBN 0727915223. Order phone 011-44-171-387-4499.Advances in the Treatment of Atrial Tachyarrhythmias: Pacing, Cardioversion, and DefibrillationCW Israel and S Barold, eds. 446 pages. Armonk, NY: Futura; 2002. $127.00. ISBN 0879934972. Order phone 800-877-8761.Cardiac Arrhythmias after Surgery for Congenital Heart DiseaseS Balaji, PC Gillette, and CL Case, eds. 360 pages. Boston: Arnold; 2001. $99.00. ISBN 0340762071. Order phone 800-368-5777.Cardiac Pacing and ... Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 5 February 2002Volume 136, Issue 3Page: B1 ePublished: 5 February 2002 Issue Published: 5 February 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.Loading ...
An improved system for reporting congenital malformations
Authors: S. D. Minton
Journal: JAMA (1986)

To improve the system of reporting congenital malformations on the birth certificates of newborns, we initiated the following procedural changes at Utah Valley Regional Medical Center in 1981: (1) transference of the responsibility of reporting congenital malformations from the mother's physician to the newborn's physician; (2) development of a congenital malformation reporting sheet included in each newborn's file; and (3) appointment of a centralized single hospital medical records person to review the files and to complete the birth certificate. For 4949 births in 1982, the results of these changes were reviewed retrospectively and compared with those of a previous study at the institution. This system markedly improved the overall completeness of reporting while it identified inaccurate reporting of some malformations, incomplete reporting of multiple malformations, and the reporting of nonmalformations as congenital malformations. (<i>JAMA</i>1986;256:2976-2979)
Routine postprandial blood glucose determinations in a general hospital
Authors: R. F. Berris
Journal: JAMA (1966)

The value and feasibility of performing routine twohour blood glucose determinations on all admissions to a general hospital was studied in 2,472 patients. A high percentage (13%) of positive results was obtained with more than half of these showing carbohydrate intolerance after glucose tolerance test. The number of positive reactions increases markedly with age. New criteria are needed for the diagnosis of diabetes mellitus in the inactive, sick, or aged patient, but the carbohydrate intolerance demonstrable on two-hour postprandial blood glucose tests appears to be of value in discovering the asymptomatic potential diabetic. The glucose tolerance test should be performed if diabetes mellitus is clinically suspected, even though the two-hour postcibum test is normal. Clinical acumen was rewarded with evidence of diabetes mellitus in 25% of suspects with normal postprandial glucose levels.
SAMUEL GARTH (1661-1718) THE KIT-KAT POET
Journal: JAMA (1966)

Samuel Garth, clever and fashionable physician in London, left no medical manuscripts, but his doggerel verse attests to literary accomplishments which justified his membership in the Kit-Kat Club. The scanty information regarding his professional and private life was brought up to date by Harvey Cushing early in this century.<sup>1</sup>It is known that Garth lived in Covent Garden, London, was in demand as a practicing physician, typified the upper-class man of his day, and grew rich in practice. Under George I he was knighted and became physician-in-ordinary to the king and physician-general to the army. Garth was born in the West Riding of York-shire, was schooled at Ingleton, and entered Peter-house in Cambridge where he graduated BA in 1679 and MA in 1684. After studying medicine at Leyden he received the MD degree from Cambridge in 1691 and then settled in London. Two years later he was elected a
Building or Extending a Hospital Department: Radiology a Path through the Planning Minefield
Authors: E J Roebuck, D J Manton, G L Fordham
Journal: Journal of the Royal Society of Medicine (1987)

This is the first of a series of articles on the planning and building of a new radiology department or the extension of an old one. While the series focuses on a radiology department, it will be of interest to anyone who is planning any part of a hospital, particularly in the detailed information about the planning process and the part to be played by hospital staff during the subsequent building and commissioning.
Communitywide Cryptosporidiosis Outbreak—Utah, 2007
Journal: JAMA (2008)

Cryptosporidiosis is a nationally notifiable gastrointestinal illness caused by chlorine-resistant protozoa of the genus Cryptosporidium. Fecal-oral transmission of Cryptosporidium occurs via ingestion of contaminated recreational water, drinking water, or food, or via contact with infected persons or animals (e.g., cattle). Incidence peaks in late summer and coincides with the summer swimming season. The number of nonoutbreak cryptosporidiosis cases reported nationally increased from 3,411 cases in 2004 to nearly 8,300 in 2007 (CDC, unpublished data, 2008). This substantial increase (143%) mirrors the increase in the number of nationally reported cryptosporidiosis outbreaks associated with treated recreational water venues (e.g., pools, water parks, and interactive fountains): seven reported treated recreational water-associated outbreaks in 2004, 19 in 2006, and, as of September 5, 2008, provisional reports of 26 in 2007 (CDC, unpublished data, 2008). This report describes a communitywide cryptosporidiosis outbreak in Utah that likely was associated initially with treated recreational water venues and subsequently with person-to-person transmission. Cryptosporidium's ability to cause communitywide outbreaks, which is attributable to factors such as its chlorine resistance, underscores the need for more rapid implementation of control measures once an increase in case reporting is noted rather than waiting for an outbreak investigation to implicate a specific source of transmission. Such a response should include 1) pre-outbreak planning and preparation, 2) pre-outbreak adoption of a disease action threshold (e.g., a twofold to threefold increase in cases over baseline), and 3) rapid mobilization of community partners to implement control measures once the threshold is exceeded.
Epidemiology of AIDS in women in the United States. 1981 through 1986
Authors: M. E. Guinan
Journal: JAMA (1987)

An analysis of 1819 cases of acquired immunodeficiency syndrome (AIDS) in women reported between 1981 and 1986 showed that the majority of women with AIDS were intravenous drug users. The second most common risk group was heterosexual contact with a person at risk for AIDS. The proportion of women with AIDS in this risk group increased significantly between 1982 and 1986, from 12% to 26%. This trend may prove to be a good marker for following trends in heterosexual transmission. Since the majority of childhood AIDS cases are a result of perinatal transmission from the mother, trends in AIDS cases in women may also predict future trends for AIDS in children. (<i>JAMA</i>1987;257:2039-2042)
Caspase-8 inactivation in T cells increases necroptosis and suppresses autoimmunity in<i>Bim</i><sup>−/−</sup>mice
Authors: Toshiyuki Bohgaki, Julien Mozo, Leonardo Salmena, Elzbieta Matysiak-Zablocki, Miyuki Bohgaki, Otto Sanchez, Andreas Strasser, Anne Hakem, Razqallah Hakem
Journal: The Journal of Experimental Medicine (2011)
Heberden Society
Journal: Annals of the Rheumatic Diseases (1955)

Manchester University): Spondylitis and Heart Disease.A group of patients was encoun- tered who appear to have developed valvular heart lesions, an unusual form of spondylitis, and in some cases a chronic peripheral polyarthritis, after repeated and prolonged attacks of rheumatic fever.A few patients with typical ankylosing spondylitis were found to be suffering from aortic incompetence.The relationship of heart and joint lesions in these patients was discussed.
Minerva
Journal: BMJ (2005)

with the findings of Hill et al and Devereaux et al might reflect the difference in response rate, criteria for adequate concealment, recentness of the included trials, or the strategies for contacting and phrasing the questions to the investigators.It is prudent to assume that a notable fraction of the overestimation of the treatment effect associated with unclear allocation concealment is caused by selection bias.This fraction can be reduced through several mechanisms.Journals should endorse and enforce the consolidated standards of reporting trials statement (www.consort-statement.org),which recommends explicit description of the allocation procedures in publications of trials, and the gatekeepers who sanction protocols for funding and approval should demand that adequate methods are described in protocols and implemented in trials.Furthermore, our study adds to the argument that protocols should be made publicly available, 9 18 19 because public access would increase the reliability of critical appraisal of the fraction of trials where the protocol does describe methods for allocation concealment.We thank the scientific and ethical committees for Copenhagen and Frederiksberg, who provided access to the trial protocols and offered administrative support; the researchers who responded to the questionnaires; and J Hedegaard for secretarial support.
BRONCHIAL ASTHMA
Authors: David L. Engelsher
Journal: JAMA (1952)

<h3>To the Editor:</h3> —The articles on bronchial asthma by Drs. Unger and Abramson that appeared in the Oct. 11, 1952, issue ofThe Journalwere excellent. Emphasis must be placed repeatedly on the danger of using morphine in asthma, as it so often is a cause of death in status asthmaticus. This applies to other strong respiratory depressants, like meperidine hydrochloride. I should like to add a suggestion for the prevention of what I call "nasal-descending asthma," a condition frequently following "head colds," which may provoke, especially in children, acute exacerbations of the severest type. I classify this into two forms, one in which severe asthma follows the nasal symptoms after minutes to hours and the other in which the severe chest symptoms occur after one or two days. The use of epinephrine in oil as Dr. Unger suggests is good for the first type, the more rapidly developing form.
National Cancer Institute Monograph No. 13
Journal: JNCI Journal of the National Cancer Institute (1964)

Journal Article National Cancer Institute Monograph No. 13 Get access JNCI: Journal of the National Cancer Institute, Volume 32, Issue 4, April 1964, Page 960, https://doi.org/10.1093/jnci/32.4.960 Published: 01 April 1964
Highlights
Journal: JAMA (2016)

Eff ect of Noninvasive Imaging Strategies on Angiography Rates 1051Rates of angiography are considered too high among patients with suspected coronary heart disease (CHD), and limited empirical data address strategies to reduce angiography rates.In a randomized trial that enrolled 1202 patients from 6 hospitals in the United Kingdom, Greenwood and colleagues found that a cardiovascular magnetic resonance imaging (CMR)-guided care strategy produced a lower probability of protocol-defi ned unnecessary angiography in the subsequent 12 months than care guided by the UK National Institute for Health and Care Excellence guidelines.Unnecessary coronary angiography rates did not diff er between CMR-guided and myocardial perfusion scintigraphy-guided care. A Value-Driven Outcomes Program, Health Care Cost, and Quality 1061Lee and colleagues assessed the association of a value-driven outcomes tool that allocates cost of care and quality measures to individual patient encounters with cost reduction and health outcome optimization in an analysis of data from 1 health care system with 1.7 million patient visits per year.In before-and-after comparisons, the authors found that implementation of the analytic tool was associated with reduced costs and improved quality for the 3 designated project outcomes-total joint replacement, laboratory testing among medical inpatients, and sepsis management.In an Editorial, Porter and Lee discuss the transition from volume to value in health care.
Highlights From the <i>Circulation</i> Family of Journals
Authors: Benjamin Steinberg, Dajuanicia Holmes, Karen Pieper, Larry Allen, Paul Chan, Michael Ezekowitz, James Freeman, Gregg Fonarow, Bernard Gersh, Elaine Hylek, Peter Kowey, Kenneth Mahaffey, Gerald Naccarelli, James Reiffel, Daniel Singer, Eric Peterson, Jonathan Piccini, Rachel Ogilvie, Michael Genuardi, Jared Magnani, Susan Redline, Martha Daviglus, Neomi Shah, Mayank Kansal, Jianwen Cai, Alberto Ramos, Barry Hurwitz, Sonia Ponce, Sanjay Patel, Carlos Rodriguez, Giuseppe Tarantini, Giulia Masiero, Luca Fovino, Jason Wasfy, Michael Hidrue, Jacqueline Ngo, Varsha Tanguturi, Elizabeth Cafiero- Fonseca, Ryan Thompson, Natalie Johnson, Susan Mcdermott, Jagmeet Singh, Marcela Del Carmen, Timothy Ferris, Jesse Veenis, Hans-Peter Brunner, La Rocca, Gerard Linssen, Marco Van Gent, Arno Hoes, Jasper Brugts
Journal: Circulation (2020)

This study assessed factors associated with improvements in quality of life among outpatients with atrial fibrillation in ORBIT-AF (Outcomes Registry for Better Informed Treatment of Atrial Fibrillation).Potentially treatable atrial fibrillation risk factors were associated with large health-related qualityof-life improvement, and less reversible conditions appeared negatively associated with healthrelated quality of life improvement.The study suggests that identifying which patients are most likely to have large health-related quality-of-life improvement will facilitate targeting interventions for high-value care that optimizes patient-reported outcomes in atrial fibrillation risk.
Polymorphisms of factor V Leiden, prothrombin e methylenetetrahydrofolate reductase in patients with coronary disease Antonio P. Mansur, Joyce M. Annicchino-Bizzacchi, Jos� A.F. Ramires. Heart Institute (InCor), University of S�o Paulo Medical School, S�o Paulo, Brazil
Journal: Journal of the American College of Cardiology (2001)