tbuckley/cabot-search huggingface dataset:
Hemodynamic Studies of a Monoamine Oxidase Inhibitor, DL-Serine-N2-Isopropylhydrazide (RO 4-1038): Mechanism of Hypotensive Action
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells
Authors: Michael G. Kharas, Matthew R. Janes, Vanessa M. Scarfone, Michael B. Lilly, Zachary A. Knight, Kevan M. Shokat, David A. Fruman
Journal: Journal of Clinical Investigation (2017)

An incorrect image was included for the β-actin blot.In addition, the blots for 4EBP-1, p-AKT, and total AKT were stretched in the original figure.
Neural Mechanisms in Poliomyelitis
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Morning Prayer
Authors: Jay S. Auslander
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Otolaryngology—Head and Neck Surgery
Authors: Byron J. Bailey
Journal: JAMA (1981)

The name change of our specialty's two largest organizations (the Academy and the Council) to "otolaryngology-head and neck surgery" reflects the evolution and emphasis of training and practice during the past three decades and should serve to identify us more clearly for patients and other physicians. <h3>Otology</h3> Secretory otitis, or otitis media with effusion, is the most common reversible otologic condition we encounter. A number of provocative articles published recently have given us more insight into this problem. Using a new micro-method, Ingelstedt et al<sup>1</sup>have shown that the effusion fluid has an average PO<sub>2</sub>of 41 mm Hg, a PCO<sub>2</sub>of 58 mm Hg, and a pH of 7.24. They suggest that these findings reflect decreased perfusion of the middle-ear membranes but doubt that the fluid would be favorable for growth of anaerobic bacteria. Important etiologic factors in secretory otitis were analyzed by Tos et al,
Treatment of soft-tissue infection with cephalexin. An orally administered cephalosporin antibiotic
Authors: J. Page
Journal: JAMA (1970)

Cephalexin monohydrate, an orally administered cephalosporin C antibiotic, was evaluated in the treatment of 25 patients with soft-tissue infections of sufficient severity to warrant antibiotic therapy. All strains of Staphylococcus aureus, both penicillin-sensitive and penicillinresistant, were inhibited by 12.5μg or less of cephalexin monohydrate per milliliter. These concentrations of cephalexin were usually achieved in the serum one to two hours after a 500-mg oral dose and correlated with serum inhibitory activity against the infecting microorganism. Excellent clinical response and elimination of the pathogen were noted within seven days after initiation of therapy in all but one patient. Side effects were severe diarrhea in one patient which necessitated discontinuation of cephalexin therapy after the first day; eosinophilia in one patient; and a slight rise in the value of serum glutamic oxaloacetic transaminase in one patient.
ANTENATAL CLINICS AND PREMATERNITY PRACTICE AT THE EDINBURGH ROYAL MATERNITY HOSPITAL IN THE YEARS 1909-1915
Authors: J. W. Ballantyne
Journal: BMJ (1916)

prematernity work was definitely commenced in the Edinburgh Royal Maternity Hospital with the opening of the Hamilton Bed-a bed set apart and endowed for the purpose of the treatment of the diseases peculiar to, or accidental during, pregnancy.A few -Years later, with the consent of the directors of the h1ospital, th1e bed became a ward, and was known as the "prematernity ward"; and I bave from time to time reported on th1e work-done therein, sometimes in the form of descriptions of special cases, and at other times in that of lists of maladies dealt with.My last report, which summarized the Cases treated in the autumn quarter of 1908, appeared in the February and MarCh parts of the Journal of Obstetrics and Gynaecology of the British Emipire for 1909.1 Since 1908 I have continued to be in charge of the hospital during the autumn quarter of each1 year, and I now bring forward notes on the cases dealt With1 during these seven recurriPg periods in the pe- m11aternity ward.Before, however, the records of these experiences are set forth it may be useful and interesting to outline the exteu1sions of .theprematernity and antenatal work of the
Up‐regulation of amphotrophic retroviral receptor expression in human peripheral blood CD34+ cells
Authors: Andreas Kaubisch, Maureen Ward, Stuti Schoetz, Charles Hesdorffer, Arthur Bank
Journal: American Journal of Hematology (1999)

Retroviral-mediated gene transfer into hematopoietic stem cells provides the only means of stable transduction of these cells and their progeny for use with a variety of potentially therapeutic genes. Expression of the Moloney amphotropic retroviral receptor—pit-2 or GLVR-2—is critical to the recognition and entry of Moloney leukemia virus-derived viruses into human target cells such as CD34+ hematopoietic cells. GLVR-2 functions as a sodium-dependent phosphate transporter as well as a receptor. We have previously shown that the expression of the murine homologue of the amphotropic receptor Ram 1, also a phosphate transporter, is developmentally regulated in murine hematopoietic fetal liver cells. We also demonstrated that culture of murine fetal liver cells in phosphate-free (PO4-free) medium increases levels of receptor mRNA and makes murine fetal liver cells susceptible to Moloney amphotropic viral gene transfer. We now examine the effect of culture conditions on the expression of GLVR-2 in human CD34+ cells. In this report, we demonstrate that there is a 2–3 fold increase in GLVR-2 mRNA levels in CD34+ cells after 3 days in culture with interleukin 3, interleukin 6, and stem-cell factor. In addition, the use of PO4-free medium increases expression of GLVR-2 an additional 2-fold in these cells during this time. These results indicate that GLVR-2 expression can be up-regulated on these cells, and may permit improved retroviral gene transfer efficiencies. Am. J. Hematol. 61:243–253, 1999. © 1999 Wiley-Liss, Inc.
Immunization
Authors: Donald C. Anderson
Journal: JAMA (1987)

PREVENTION of disease by immunization predates knowledge of infection or immunology in human history. Inoculation of smallpox material intranasally in an effort to prevent smallpox was first noted in 590 BC in the Sung Dynasty. From such empiric beginnings are derived immunization practices, built on centuries of casual and painstaking observation, intuition, and scientific experiment. Current immunization practices are based on immunologic aspects of the host response, the state of microbiological technology, restraints of practicality, and economic, ethical, and medicolegal considerations. The recent elimination of smallpox represents the final chapter in a 2500-year history of vaccination that has included all of the previously mentioned factors.<sup>1</sup> Active immunization is based on the premise that immunologic mechanisms appropriate for defense against microorganisms can be evoked in the absence of significant infectious risk to the host. Exposure to an infectious agent initiates a variety of cellular and molecular responses. Collectively, these responses
The Practical Care of the Baby.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Utah Instead of Michigan.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Investigators Examine Effects Of Acceleration
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Effect of 60-Hz Magnetic Fields on Co-Promotion of Chemically Induced Skin Tumors on SENCAR Mice: A Discussion of Three Studies
Authors: Jack R. N. McLean, Art Thansandote, David Lecuyer, Michael Goddard
Journal: Environmental Health Perspectives (1997)

Three independent experiments involving a total of 288 SENCAR mice were used to study the effects of 60-Hz magnetic fields on the growth and development of skin tumors. Given the constraints imposed by the experimental design, the results did not support a role for magnetic fields as a tumor co-promoter. This negative finding could also be interpreted to mean that the SENCAR mouse skin tumor model was not sensitive enough to detect the action of a weak co-promoter. The two-stage (initiation/promotion) model was used to assess the genotoxic potential of magnetic fields because it had been widely used to evaluate chemical carcinogens. This model, however, lacks the sensitivity to detect all but the most potent direct-acting carcinogens, and the tumor response to the action of low doses of promoter results in large random fluctuations in tumor incidence, yield, and multiplicity. The need to limit tumor incidence in the sham is a necessary condition to ensure that a magnetic field-induced effect on tumorigenesis would have a reasonable chance of being detected. This requirement, and the variability in tumor development between and within experiments, increases the level of uncertainty in the system and makes a weak response to the magnetic field difficult to detect and interpret.
Science, Washington
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dr. Burns Installed as President.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Angiographic and clinical reasons for the higher mortality of women with acute myocardial infarction in comparison with men when treated with primary angioplasty Ra�l Moreno, Eulogio Garcia, Leopoldo P�rez de Isa, Javier Soriano, Manuel Abeytua, Rafael Rubio, Esteban L�pez de S�, Jos�-Send�n. Hospital Gregorio Mara��n, Madrid, Spain
Journal: Journal of the American College of Cardiology (2001)
The greater risk of alcoholic cardiomyopathy and myopathy in women compared with men
Authors: A. Urbano-Marquez
Journal: JAMA (1995)

<h3>Objective.</h3> —To compare the cardiac and muscular status of male and female alcoholics to determine if the response of women to alcohol is different from that of men. <h3>Design.</h3> —Cross-sectional study. <h3>Setting.</h3> —An ambulatory alcoholism treatment unit in the Hospital Clinic of Barcelona. <h3>Patients.</h3> —Fifty asymptomatic alcoholic women, 100 asymptomatic alcoholic men, and 50 female nonalcoholic controls. <h3>Main Outcome Measures.</h3> —Studies included clinical assessment of muscle strength, muscle biopsy, echocardiography, radionuclide cardiac angiography, and treadmill exercise electrocardiographic recording test. <h3>Results.</h3> —The mean strength of the deltoid muscle in alcoholic women was significantly lower than that in controls (<i>P</i>&lt;.001) and half suffered clinical weakness (muscle strength ≥2 SD below controls). Muscle biopsy specimens from half of all asymptomatic women showed histologic evidence of myopathy. Left ventricular ejection fractions tended to be depressed, and a third of the alcoholic women had evidence of cardiomyopathy. Muscular strength and ejection fractions in women were inversely correlated with the total lifetime dose of ethanol, whereas the left ventricular mass showed a direct correlation. Of the alcoholic men, 39% suffered clinical weakness, and 45% had histologic evidence of myopathy. Evidence of cardiomyopathy was found in almost a third of the men, and their ejection fractions also correlated inversely with the total lifetime dose of ethanol. However, the threshold dose for the development of cardiomyopathy was considerably less in women than in men, and the decline in the ejection fraction with increasing alcohol dose was significantly steeper (<i>P</i>&lt;.001). <h3>Conclusions.</h3> —Despite the fact that the mean lifetime dose of alcohol in female alcoholics was only 60% that in male alcoholics, cardiomyopathy and myopathy were as common in female alcoholics as in male alcoholics. This finding, together with a more pronounced response of the ejection fraction to the dose of ethanol, indicates that women are more sensitive than men to the toxic effects of alcohol on striated muscle. (<i>JAMA</i>. 1995;274:149-154)
THE INFLUENCE OF BURNS ON THE ANIMAL ORGANISM.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hofrat Riehl
Authors: Gustav Riehl
Journal: JAMA (1967)

<h3>To the Editor:—</h3> Your editorial on Gustav Riehl (<b>200</b>:790, 1967) was another of your laudable contributions to the history of medicine. Within it, however, lies a small misunderstanding, which may have occurred during a translation. The article stated that Riehl served a short internship in Bamberg. Undoubtedly this referred to his service as an "Aspirant" (1879-1880) in the clinic of Professor Bamberger. This would have been the equivalent of the first stage of an internship. I remember how puzzled I was one day in 1949 at Obermayer's clinic in Los Angeles, when a student read a paper about a German dermatologist,—I think it was Neisser. What struck me was the great sense of tradition and interest in history of medicine. The article on my father struck me for the same reason. What the author writes seems pretty accurate, except for a few little things. My father was born, not