tbuckley/cabot-search huggingface dataset:
UNCLASSIFIED MYCOBACTERIAL INFECTIONS
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Empirical Bayes Methods for Smoothing Data and for Simultaneous Estimation of Many Parameters
Authors: Takemi Yanagimoto, Nobuhisa Kashiwagi
Journal: Environmental Health Perspectives (1990)

A recent successful development is found in a series of innovative, new statistical methods for smoothing data that are based on the empirical Bayes method. This paper emphasizes their practical usefulness in medical sciences and their theoretically close relationship with the problem of simultaneous estimation of parameters, depending on strata. The paper also presents two examples of analyzing epidemiological data obtained in Japan using the smoothing methods to illustrate their favorable performance.
As AIDS Epidemic Approaches Second Decade, Report Examines What Has Been Learned
Authors: Marsha F. Goldsmith
Journal: JAMA (1990)

ONCE UPON a time, no one in the world had ever heard of the acquired immunodeficiency syndrome (AIDS). Neither was the human immunodeficiency virus (HIV) known. That state of innocence ended forever less than 10 years ago. A new report from the Committee on AIDS Research and the Behavioral, Social, and Statistical Sciences, a part of the National Research Council, sums up what has been learned in the past 9 years and discusses the evolving course of the epidemic in the United States.<i>AIDS: The Second Decade</i>(edited by Heather G. Miller, Charles F. Turner, and E. Lincoln Moses, National Academy Press, Washington, DC, 1990), was introduced in San Francisco in conjunction with the Sixth International Conference on AIDS. <h3>Prevention, Intervention</h3> The report addresses such topics as disease prevention and behavioral intervention, adolescents at risk, new problems concerning the blood supply, and issues involved in conducting the surveys deemed vital
THE ANNUAL RECKONING.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PENETRATION OF ULTRAVIOLET RAYS OF THE MERCURY VAPOR LAMP
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
<i>QuickStats:</i> Age-Adjusted Rates* of Suicide,† by State— National Vital Statistics System, United States,§ 2017
Journal: MMWR Morbidity and Mortality Weekly Report (2019)

Abbreviation: DC = District of Columbia.* Deaths per 100,000 population, age-adjusted to the 2000 U.S. standard population.† Suicides are identified using the International Classification of Diseases, Tenth Revision underlying cause of death codes U03, X60-X84, and Y87.0.§ The overall U.S. age-adjusted rate for suicide was 14.0 per 100,000 population in 2017.In 2017, the U.S. age-adjusted suicide rate was 14.0 per 100,000 population, but rates varied by state.The five states with the highest rates were Montana (28.9 deaths per 100,000 population), Alaska (27.0), Wyoming (26.9),New Mexico (23.3), and Idaho (23.2).The five with the lowest rates were the District of Columbia (6.6), New York (8.1),New Jersey (8.3), Massachusetts (9.5), and Maryland (9.8).
Current Studies Of 'Near-Drowning'
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Essai randomisé comparant prophylaxie pharmacologique seule versus endoprothèse pancréatique et prophylaxie pharmacologique pour la prévention de la pancréatite post-cpre chez les patients à risque élevé
Journal: Endoscopy (2019)

La pancréatite post-CPRE (PPC) survient chez 9 à 42 % des patients, selon les facteurs de risque et les indications de la CPRE. L'efficacité des anti-inflammatoires non stéroïdiens (AINS) administrés par voie rectale pour la prévention de la PPC a été démontrée et l'administration rectale d’AINS pendant la CPRE est recommandée chez les patients à risque élevé. Les nitrates peuvent également jouer un rôle dans la prévention de la PEP, ainsi qu’une hydratation adéquate par solution de Ringer lactate.
An Industrial Approach to Evaluation of Pyrolysis and Combustion Hazards
Authors: R. S. Waritz
Journal: Environmental Health Perspectives (1975)

In addition to the usual toxicology studies necessary for the safe manufacture and use of polymers at room temperature, special studies are needed for polymers which will be used at elevated temperatures. This paper discusses various areas to be investigated and principles for deciding on test materials, tests, and test conditions, polytetrafluoroethylene (PTFE) and fluorinated polyethylene-propylene (PFEP) pyrolysis studies being used as an illustrative case history. Some limitations of animal testing also are mentioned. A toxicological spectrum relating toxicological determinants to PTFE temperature is developed.
Heberden Society: Annual Report, 1960
Authors: Rhys Davies, C Clark, P Davis, Charlotte Feldman, V Steinberg, J Scott, H Wykeham- Balme, D Newton, C Croft, E Hamilton, Mary Carter, I Porter, W Wenley, G Asherson, J Golding, R Parkins, A Willcox, M Keech, F Baragar, J Webb, E Hess, J Forestier, J De Blcourt, K Meijers, F Hart, G Kersley, Barbara Ansell, G Newnes, W Copeman, Harley Street, W London, Wilfred Wilks, F Econ, M Andrews, Arthur Stanley
Journal: Annals of the Rheumatic Diseases (1961)
Localization and cellular sources of activins in normal and fibrotic rat liver
Authors: P De Bleser
Journal: Hepatology (1997)

Activins are dimeric proteins, members of the transforming growth factor β (TGF-β) gene superfamily, consisting of the β-subunits of inhibin (βA and βB). Recently, it was shown that activin A (βA:βA) inhibits DNA replication and induces apoptosis in rat parenchymal cells in vitro and in vivo. Cryostat sections of normal livers and livers of rats treated with intraperitoneal injections of CCl4 were stained for the different inhibin subunits and desmin, a marker for stellate cells (SC). Staining for inhibin-α was invariably negative, both in normal and fibrotic rat liver. In normal liver, inhibin-βA subunit immunoreactivity was localized in parenchymal cells (PC). Staining for inhibin-βB was weaker but similarly distributed. In fibrotic livers, connective tissue septa were strongly immunoreactive for inhibin-βA. Desmin-positive stellate cells (SC) accumulated in areas strongly immunoreactive for inhibin-βA and several cells were positive for both desmin and inhibin-βA. Staining for inhibin-βB was weaker but similarly distributed. As above data pointed to a possible role for PC and SC, we examined by Northern blot analysis, the expression of inhibin-α, -βA, and -βB messenger RNA (mRNA) in total RNA extracted from freshly isolated SC and PC of normal and CCl4-treated liver and in cultured SC. Inhibin-βA mRNA was predominantly expressed in PC of normal liver. Expression was lost in PC of CCl4-treated liver. Inhibin-βB mRNA expression was induced in SC of CCl4-treated liver. Inhibin-βA mRNA, and to a lesser extent, inhibin-βB mRNA expression was rapidly induced in cultured SC. The presence of activin A in conditioned media of cultured SC was shown by Western blotting. Apoptotic cells, identified by terminal deoxy-transferase mediated X-dUTP nick end labeling (TUNEL)-staining, were found predominantly in and near the fibrotic septa. In conclusion: 1) while activin A was constitutively expressed in PC of normal liver, its expression was lost in PC of fibrotic liver; 2) expression of activins was induced in activated SC; and 3) apoptotic cells were found predominantly near the septa, in support of the hypothesis that activin A, derived from activated SC in the septa, contributes to the induction of cell death in neighboring PC.
Air Pollution, Public Health, and Inflation
Authors: Bart David Ostro
Journal: Environmental Health Perspectives (1980)

Since the passage of the environmental legislation in the early 1970's, critics have attacked these laws as being unnecessary and for contributing significantly to the problem of inflation in the United States. This paper is an attempt to put the inflationary costs of air pollution into perspective by considering them in light of the cost, especially to public health, of not proceeding with pollution control. There is now a great deal of evidence that the concentration of certain pollutants in the air can contribute significantly to the incidence of respiratory and cardiovascular diseases and to certain forms of cancer. On the basis of the results of a recent study of the impacts of pollution control on inflation, the annual reduction in purchasing power of the average family is calculated to be $31 per family. To determine the average costs of air pollution on human health, research by Lave and Seskin is utilized. First, the implications of air pollution for mortality and morbidity rates are determined. Then, the reduction in direct health costs and indirect costs (lost productivity of workers) as a result of pollution abatement is estimated. These annual health costs from pollution total approximately $250 per family. The results suggest that the inflationary costs of air pollution control are more than offset by the damages to public health from unabated air pollution.
Gene Expression and Therapy
Authors: Agustin Gonzalez, Tomas Rybertt, Juan Arab, Margarita Pizarro, Nancy Solis, Marco Arrese, Huang Feng, Dan Wang, Pu Chen, Ping Yang, Cao Ju, Zhang Ping, Yutaka Midorikawa, Shogo Yamamoto, Hiroki Ueda, Kotaro Sonoda, Shingo Tsuji, Kenji Tatsuno, Tatsuhiro Shibata, Kyle Covington, David Wheeler, Tadatoshi Takayama, Hiroyuki Aburatani, Daniela Sia, Bojan Losic, Kate Revill, Ke Hao, Laia Cabellos, Zhongyang Zhang, Yujin Hoshida, Sasan Roayaie, Swan Thung, Myron Schwartz, Samuel Waxman, Vincenzo Mazza- Ferro, Eric Schadt, Josep Llovet, Ana Sobrevilla-Navarro, Ana Sandoval-Rodriguez, Jesus Gar- Cia-Banuelos, Luis Hernández-Ortega, Jose Macias-Barragan, Juan Armendáriz-Borunda, Adriana Salazar Montes, Zoe Raglow, Chuanghong Wu, Yu- Jui Wan, Khaleel Jamil, Kuldeep Cheent, Michael Heneghan, Marco Purbhoo, Salim Khakoo
Journal: Hepatology (2013)

PG. Cyp7a1 hepatic expression was induced in and .This was associated to a reduced ileal Fgf15 gene expression in both groups (relative mRNA levels: 0.38±0.1 in PG and 0.08±001 in CTM vs. 1.102±0.23 in CG, p<0.05).Of note, CTM ileal gene expression of Fgf15 was significantly lower than PG (p<0.05).Conclusions: We confirmed the occurrence of down-regulation of export and import biliary genes and an upregulation of hepatic Cyp7a1 gene expression during pregnancy in mice.Ileal down-regulation of FGF15 gene expression is likely contributory to the observed pregnancy-associated upregulation of Cyp7a1 gene expression in the liver.In a setting of decreased canalicular export, increased expression of Cyp7a1 may raise bile salt levels inside the hepatocyte and contribute to cholestasis during pregnancy.
Use of Angiotensin as Adjuctive Agent to Correct Hypotensive States During Anesthesia
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mercury Exposure Among Residents of a Building Formerly Used for Industrial Purposes—New Jersey, 1995
Journal: JAMA (1996)

Potential sources of elemental mercury in residential settings include mercury switches, mercury-containing devices (e.g., thermostats and thermometers), and mercury obtained from laboratories, dental offices, or other industrial sources. In January 1995, pools of elemental mercury were found in a five-story factory building that had been converted to residential use in Hoboken, New Jersey; the building previously had been used to manufacture mercury vapor lamps. This report summarizes the investigation by the New Jersey Department of Health (NJDOH), the U.S. Environmental Protection Agency (EPA), the Agency for Toxic Substances and Disease Registry (ATSDR), the Hoboken Board of Health, and the Hudson Regional Health Commission (HRHC), which identified high levels of mercury vapor in the building and indicated that residents had been exposed to high levels of mercury.
A Call for Action
Authors: Sen John D. Rockefeller
Journal: JAMA (1991)

After a year of deliberation and investigation, the Pepper Commission recommended action to ensure that all Americans would have health insurance protection in an efficient, effective health care system. Because it believes that action is urgent, the commission would build universal coverage by securing, improving, and extending the combination of job-based and public coverage we now have. Reform would entail the following elements: a combination of incentives and requirements that would guarantee all workers (with their nonworking dependents) insurance coverage through their jobs; replacement of Medicaid with a new federal program that would cover all those not covered through the work-place and workers whose employers find public coverage more affordable; guaranteed affordable coverage for employers—through reform of private insurance, tax credits for small employers, and the opportunity to purchase public coverage; a minimum benefit standard for private and public plans that would cover preventive and primary services as well as catastrophic care and would include cost sharing, subject to ability to pay; and a combination of public and private sector initiatives to promote quality and contain costs. (<i>JAMA</i>. 1991;265:2507-2510)
Use of BRCA1 mRNA expression levels to predict survival in breast cancer patients (p) treated with neoadjuvant chemotherapy
Authors: M. Margelí, B. Cirauqui, E. Castellà, G. Tapia, C. Costa, A. Gimenez-Capitan, O. Etxaniz, A. Ariza, M. Tarón, R. Rosell
Journal: Journal of Clinical Oncology (2008)

11510 Background: A fraction of sporadic breast cancers have low BRCA1 expression. These p can respond to DNA damage-based chemotherapy but not to antimicrotubule drugs. In addition, DNA damage-based chemotherapy confers a significant survival advantage to BRCA1 mutation carriers compared to non-mutation carriers. Also ovarian cancer p with low levels of BRCA1 mRNA have improved survival following platinum-based chemotherapy compared to p with high levels of BRCA1 mRNA (Quinn et al, CCR 2007). Methods: Tumor biopsies were obtained from 86 p with locally advanced breast cancer who were treated with four cycles of neoadjuvant fluorouracil, epirubicin and cyclophosphamide (FEC). Estrogen receptor (ER), progesterone receptor (PR), HER2, cytokeratin 6/7, vimentin, Huntingtin interacting protein 1 (HIP1) and BRCA1 were examined by tissue microarray. HER2 was also assessed by CISH, and BRCA1 mRNA was analyzed in samples of 41 p by quantitative PCR. Results: Pathological response was attained in 57% of p. Median disease-free survival (DFS) was 30 months (m) and median survival (MS) was 41 m. There was no correlation between BRCA1 protein expression by immunohistochemistry and BRCA1 mRNA expression. In the multivariate analysis for DFS and MS, low levels of BRCA1 mRNA, positive PR and negative lymph node involvement predicted significantly lower risk of relapse, and low levels of BRCA1 mRNA and positive PR were the only variables associated with significantly better survival (table). Conclusions: We provide evidence to support a major role for BRCA1 mRNA expression as a predictive marker of DFS and MS in sporadic breast cancers. These findings can be useful for customizing chemotherapy. DFS MS N HR (95% CI) p HR (95% CI) p BRCA1 mRNA Low 13 1 1 by terciles Intermediate 14 7.68 (2.41-24.55) 0.001 4.52 (1.51-13.46) 0.007 High 12 4.52 (1.50-13.63) 0.007 2.94 (0.99-8.71) 0.05 PR Negative 26 4.15 (1.61-10.69) 0.003 2.43 (0.99-5.93) 0.05 Positive 13 1 1 Lymph node involvement Negative 6 1 Positive 33 12.01 (1.51-95.16) 0.02 No significant financial relationships to disclose.
A Randomized Trial of Integrated Group Therapy Versus Group Drug Counseling for Patients With Bipolar Disorder and Substance Dependence
Authors: Roger Weiss
Journal: American Journal of Psychiatry (2007)

Objective: Although bipolar disorder and substance use disorder frequently co-occur, there is little information on the effectiveness of behavioral treatment for this population. Integrated group therapy, which addresses the two disorders simultaneously, was compared with group drug counseling, which focuses on substance use. The authors hypothesized that patients receiving integrated group therapy would have fewer days of substance use and fewer weeks ill with bipolar disorder. Method: A randomized controlled trial compared 20 weeks of integrated group therapy or group drug counseling with 3 months of posttreatment follow-up. Sixty-two patients with bipolar disorder and current substance dependence, treated with mood stabilizers for ≥2 weeks, were randomly assigned to integrated group therapy (N=31) or group drug counseling (N=31). The primary outcome measure was the number of days of substance use. The primary mood outcome was the number of weeks ill with a mood episode. Results: Intention-to-treat analysis revealed significantly fewer days of substance use for integrated group therapy patients during treatment and follow-up. Groups were similar in the number of weeks ill with bipolar disorder during treatment and follow-up, although integrated group therapy patients had more depressive and manic symptoms. Conclusions: Integrated group therapy, a new treatment developed specifically for patients with bipolar disorder and substance dependence, appears to be a promising approach to reduce substance use in this population.