tbuckley/cabot-search huggingface dataset:
Abstract 711: Diagnosis of Acute Myocardial Ischemia by Speckle Tacking Echocardiography -A Comparative Animal Study-
Authors: Aya Ebihara, Katsu Takenaka, Koichi Kimura, Kansei Uno, Katsuhito Fuju, Hiroshi Iwata, Yutaka Yatomi, Masataka Sata, Ryozo Nagai
Journal: Circulation (2008)

Since the subendocardium is known to be more vulnerable to ischemia than the subepicardium, indexes of subendocardial function are expected to be more sensitive than indexes of whole LV wall. The aim of our study is to compare the diagnostic values of systolic and diastolic indexes measured by 2D speckle tracking echocardiography in an animal experiment. The proximal left circumflex coronary artery was balloon-occluded for 3 minutes in 14 pigs. LV short-axis view was recorded at rest and 30 minutes after release of the occlusion by transthoracic 2D echocardiography except for one pig with ventricular fibrillation. Peak circumferential and radial strain (CR, RS), peak systolic and diastolic strain rate (CSR-S′ and CSR-E′), time from QRS to peak CS and RS, time from QRS to E′, and the incidence of post-systolic shortening (PSS) were measured in the subendocardium of the LV posterior wall. ROC curve analysis of these indexes was done for the diagnosis of acute myocardial ischemia followed by reperfusion. Only 5 indexes showed significant change before and after the occlusion. ROC curve revealed that CSR-E′ had the highest predictive value for detecting the ischemic memory, followed by peak CS, and CSR-S′. Peak early diastolic circumferential strain rate of the subendocardium was the most powerful index for diagnosing ischemic memory after acute coronary occlusion. Table. Results of meaurement (mean±SD)
Eight-day survival without adrenal steroids
Authors: J. Jain
Journal: JAMA (1977)

A patient with advanced breast cancer who had undergone a total bilateral adrenalectomy in the past refused adrenal steroid replacement therapy with the idea that this would be the easiest and quickest way to end her life. However, she continued to live for more than eight days. Survival under these circumstances is unusual, and the terminal course of her illness is described. (<i>JAMA</i>237:1715-1716, 1977)
Fluoromicroscopic Studies of Bleomycin-Induced Intracellular Oxidation in Alveolar Macrophages and Its Inhibition by Taurine
Authors: Meenakshi Bhat, Yongyut Rojanasakul, Susan L. Weber, Jane Y. C. Ma, Vincent Castranova, Daniel E. Banks, Joseph K. H. Ma
Journal: Environmental Health Perspectives (1994)

The mechanism of bleomycin-induced pulmonary fibrosis is not yet clear.Recent studies have shown that alveolar macrophages (AM) can be stimu- lated by bleomycin in vitro releasing inflammatory cytokines, suggesting that the interaction of bleomycin with AM is an important step in the drug- induced fibrotic process.Bleomycin is known to bind DNA and generate oxygen radicals through complexation with Fe2+ and oxygen.To provide more insight into the cellular oxidative property of bleomycin, we have developed a fluoromicroscopic method using 2',7'-dichlorofluorescin diacetate (DCFHDA) as an oxidative fluorescence probe to study the bleomycin-induced intracellular oxidation in rat AM and the inhibition of the oxida- tion by taurine, a compound known to inhibit the bleomycin-induced fibrosis.Bleomycin at 5 to 20 pg/ml has a moderate stimulatory effect (1.87to 2.66-fold) on the secretion of superoxide anion.A high concentration of bleomycin (20 pg/ml), however, inhibits cell response to zymosan-induced secretion of superoxide anion.At 4 pg/ml, bleomycin has no effect on cell membrane integrity or morphology but results in a significant increase in intracellular oxidation.This oxidative process is Fe2-dependent and is accompanied by an increase in intracellular calcium (35 nM).Both the intracel- lular oxidation and calcium rise induced by internalized bleomycin are inhibited by pretreatment of cells with varying concentrations of taurine (25, 125, and 187.5 pM).The inhibitory effect on intracellular oxidation was found to be 36, 57, and 60%, respectively.These results demonstrate a stimulation-inhibition relationship between bleomycin and taurine on the cellular oxidation at a subcytotoxic dose of bleomycin, suggesting that the oxida- tive effect of the intracellular bleomycin-Fe2+ complex is important in the initiation of the fibrotic process.
A Dictionary of Medicine; including General Pathology, General Therapeutics, Hygiene, and the Diseases of Women and Children.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 1710: Role of Nurr1 in cervical cancer pathogenic pathway
Authors: Kok Ting Wan, Thomas Ho Yin Leung, Michelle Kwan Yee Siu, Hextan Yuen Sheung Ngan
Journal: Cancer Research (2019)

Abstract Aims: To study the oncogenic role of Nurr1 in cervical cancer and elucidate the underlying mechanism. Background: Orphan nuclear receptor related-1 protein (Nurr1) belonging to the NR4A family is important for carcinogenesis in multiple biological processes such as cell proliferation and apoptosis. It has been reported that the expression of Nurr1 is significantly correlated with various types of cancer, such as prostate and breast cancer. However, the significance of Nurr1 in cervical cancer etiology remains poorly understood. Methods: Primary cancer cells were established from tumor tissues resected from cervical cancer patients. Six pairs of attached and spheroid cells derived from primary cervical cancer tissues were established namely CP-1A/CP-1S, CP-2A/CP-2S, CP-3A/CP-3S, CP-4A/CP-4S, CP-5A/CP-5S and CP-6A/CP-6S. A microarray was performed to identify differentially expressed genes in two pairs of attached and sphere cells, followed by validation with qPCR. Stable clones of cervical cancer cell lines with Nurr1 overexpression and knock-down were generated. The role of the selected gene was then functionally characterized by XTT assay, migration assay, spheroid formation assay, apoptosis assay, in vitro and in vivo tumorigenicity assay in cervical cancer cell lines. Downstream proteins of Nurr1 were detected by western blot. Results: Microarray analysis showed that Nurr1 was highly expressed in sphere cells as compared with attached cells. Relative expression of Nurr1 mRNA in sphere cells was approximately 200-fold more than that in attached cells in qPCR validation. Cancer cell lines, in which Nurr1 was transiently knocked down by siRNA demonstrated an attenuation in proliferation rate, migration, spheroid formation and colony formation. By flow cytometric analysis, more cells were detected in early apoptotic stage with Nurr1 siRNA transfection as compared with NTC siRNA transfected cells, suggesting the role of Nurr1 in preventing cervical cancer cells from apoptosis. Western blotting also demonstrated that there was an increased expression of Bim and p21 in Nurr1 silenced cells. This may indicate the involvement of Nurr1 in modulating the transcription of pro-apoptotic and tumor suppressor genes. Conclusion: Nurr1 is a potential oncogenic target in cervical cancer pathogenic pathway. Suppression of Nurr1 expression attenuated cancer progression and promoted apoptosis. Citation Format: Kok Ting Wan, Thomas Ho Yin Leung, Michelle Kwan Yee Siu, Hextan Yuen Sheung Ngan. Role of Nurr1 in cervical cancer pathogenic pathway [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1710.
SHOULD GOVERNMENT ENCOURAGE MEDICINE, OR QUACKERY?
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Female sterilisation--no more tubal coagulation.
Journal: BMJ (1980)

At the Tokyo 9th World Congress of Gynecology and Obstetrics presentations on female sterilization emphasized the use of occlusive devices rather than thermocoagulation. In retrospect laparoscopy may be regarded as having both beneficial and deleterious effects on developing methods of sterilization. Relatively uncontrolled unipolar electrocoagulation continues to be used despite reports of adverse consequences, including burns of the abdominal wall and bowel and of pregnancy rates higher than with alternative procedures. Bipolar cautery is safer and more controlled than unipolar coagulation, but it is still unnecessarily destructive. The newer procedure of occluding the tube by plastic and silicone clips and rings appears to result in fewer complications and less tissue destruction, with similar pregnancy rates. The data on incidence of regret following sterilization and on women requesting reversal, support the current tendency in Britain for sterilization to be performed electively and not immediately after abortion or delivery, and for minimally destructive procedures to be used.
Medicolegal
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abuse of benzodiazepines
Authors: S. C. Lin
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Endocrinology
Authors: M. E. Molitch
Journal: JAMA (1990)

Diabetes mellitus continues to be a major public health problem that affects about 12 million Americans. Interesting new observations have been made regarding the development and progression of some complications of diabetes mellitus, especially nephropathy. About 25% of patients in dialysis units have diabetic nephropathy, which eventually affects about one third of those with insulin-dependent diabetes and 5% to 10% of those with non—insulin-dependent diabetes.<sup>1</sup>Certain factors may be important in predicting who may develop end-stage renal disease. Blacks, compared with whites, have an increased risk of developing end-stage renal disease that is 1.62 times greater for insulin-dependent diabetes and 3.93 times greater for non—insulin-dependent diabetes, possibly partly related to higher blood pressures in blacks.<sup>2</sup>A history of nephropathy in a diabetic sibling puts a person with insulin-dependent diabetes at considerably increased risk for developing nephropathy.<sup>3</sup>Having a parent with hypertension results in a threefold increased risk
Is Preputioplasty Effective and Acceptable?
Authors: N J Barber, B Chappell, P G Carter, J P Britton
Journal: Journal of the Royal Society of Medicine (2003)

Foreskin complaints in childhood, if not manageable conservatively, are usually treated by circumcision. A less radical surgical option, when balanitis xerotica obliterans is absent, is preputioplasty. We sent questionnaires to the parents of 23 boys who had had this procedure and 22 replied. Mean interval since operation was 20 months (range 3-36). The main indications for surgery had been irretractable foreskin in 9, recurrent balanoposthitis in 10 and ballooning on voiding in 3 and the operation had dealt successfully with these in 7, 7, and 3, respectively. In all but one case the parents were satisfied with the cosmetic result. However, in 8 cases (36%) the parents said they would have preferred circumcision and 3 of the boys had been listed for further surgery. Preputioplasty is a satisfactory alternative to circumcision in selected cases.
Identification of the functional significance of mutations using the novel Precision Cancer Analysis System.
Authors: Nir Peled, Zohar Barbash, Naama Barabash-Katzir, Hani Nevo, Michael Vidne, Mariusz Adamek, Mordechai R. Kramer, Nikolai Goncharenko, Yakov Fellig, Karen Meir, Gabi Tarcic
Journal: Journal of Clinical Oncology (2016)

e23153 Background: Mounting evidence indicates that growth of pathologically identical cancers in each individual patient is fueled by different sets of driving mutations. The need to identify these drivers stems from the recognized necessity for tailoring therapy and scheduling future surveillance. This personalized medical approach has been shown to result in better treatment outcomes. We present a novel Precision Cancer Analysis system (PCAS) capable of identifying activated signaling pathways yielding a quantitative output of particular pathway activation levels Methods: 20 cancer patients were sequenced for a panel of 37 genes and analyzed by the PCAS. This system quantifies oncogenic activity in the majority of the oncogenic signaling pathways altered by the patients’ mutations through a functional assay and does not rely on prior knowledge of the mutations. Additionally, mutations were analyzed for their sensitivity to different targeted therapy drugs Results: In 3 tested genes, 16 different mutations were identified- 4 in EGFR, 4 in PIK3CA and 8 in KRAS. Of these 10 were classified as known mutations for which functional annotation exists, and 6 were VUS. In addition to correctly annotating all known mutations, the PCAS further quantified oncogenic activity in all the VUS tested. For a subset of mutations, the sensitivity to different drugs was measured, alone and in combination Conclusions: Measuring the functional mechanism behind known mutations and VUS provides another layer of critical information to the physician. These results clearly demonstrate the value of a functional assay in accurately identifying the optimal course of treatment, particularly by its ability to add actionable information to VUS. The study produced a comprehensive delineation of the oncogenic activity of each patient’s individual mutations demonstrating the ability of the PCAS to 1) accurately deliver comparable actionable information as found by NGS, 2) functionally characterize mutations annotated as VUS, and 3) monitor oncogenic activity of signaling pathways induced by different mutations and mutation-combinations enabling informed treatment decisions
What Are Your Chances of Dying From a Norovirus Infection?
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Hospital Library. Comprising Articles on Hospital Library Service, Organization, Administration and Book Selection, Together with Lists of Books and Periodicals Suitable for Hospitals.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Massive swelling of the foot in a 63-year-old man
Authors: K. Subbarao
Journal: JAMA (1982)

<h3>History</h3> A 63-year-old nondiabetic man residing in a nursing home experienced painless massive nodular swellings of the left ankle and foot during a period of several months. Ulceration, draining sinus tracts, and foul-smelling discharge developed in the foot. The patient was treated with multiple antibiotics, external medication, and dressing, without improvement. The patient was ill-nourished on examination and demonstrated an organic brain syndrome. Physical examination results were otherwise normal. Investigations included a complete blood cell count, ESR, and chest roentgenogram, all of which gave normal results. Roentgenograms of the foot (Figs 1 and 2) were obtained. <h3>Diagnosis</h3> Madura foot. <h3>Comment</h3> An anteroposterior view of the foot with soft-tissue technique (Fig 1) and a well-penetrated roentgenogram (Fig 2) demonstrate diffuse, lobulated, nodular soft-tissue swellings enveloping the foot. Calcification is absent in the soft-tissue nodules. The underlying osseous structures do not show any erosion, reactive new bone, periosteal reaction, or osteomyelitis. The
Marriages
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal