tbuckley/cabot-search huggingface dataset:
Chlorate Poisoning
Authors: Niels C. Klendshoj
Journal: JAMA (1962)

REPORTED CASES of chlorate poisoning are not rare. In many of these cases the use of chlorates was intended for medical purposes, particularly in infections of the throat. Chlorates have also been employed as a toothpaste ingredient and poisoning has occurred from such use. The ease whereby the words "chloride" and "chlorate" can be interchanged by mistake has been, and still is, a cause of accidental poisoning. Our case falls in this category. Witthaus, in 1911, collected 155 cases of which 116 were fatal. Eighteen of these were either suicidal or homicidal. Cochran and Smith reported a case of Bright's disease in which potassium chlorate had mistakenly been given instead of potassium chloride. There was evidence that the patient took approximately 35 gm. over a period of 3 days. Death occurred on the 5th day after the last dose. Ansbacher described a rapidly progressing case of a pharmacy student who
International Comments
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 78: Cardiopulmonary and Automatic External Defibrillator handling skills evaluation in lay persons
Authors: Thiago L Silva, Luana D Olival, Ana P Quilici, Maria Margarita Gonzalez, Sergio Timerman
Journal: Circulation (2007)

Background: Since the public access of defibrillation law was approved in Sao Paulo city in 2005, it has been increasing the number of lay people who demand for cardiopulmonary resuscitation (CPR) and Automatic External Defibrillator (AED) training courses. According to the law, subway stations should have an AED and 30 per cent of the Agents should be trained in Heartsaver AED. The American Heart Association advises a Basic Life Support (BLS) refresh every two years. However, recent published papers demonstrated a significant decrease in CPR skills only 6 months following a BLS course. Hypothesis: we hypothesized that retention of skills in CPR and AED use considerably diminish after 8 month of training in Heartsaver AED course. Methods: This is an observational prospective study on the retention of CPR and AED handling skills. Twenty Subway Agents who were previously trained in these maneuvers were evaluated . The evaluation of the skills retention was performed 8 months after the success completion of the first Heartsaver AED course, consisting in a cardiopulmonary arrest simulation in a training mannequin. An experienced Heartsaver AED instructor evaluated the following performed skills: Check for response; Activate Emergency Response System and Get an AED; Open airway; Check breathing; Give two breaths; Perform compressions hard and fast in a correct hands position; AED operation Results: It was observed that the totality of the participants did not fill, at least, one of the requirements of the evaluation: 85% of the participants checked response, 55% asked for help after check response, 45% asked for help at another moment, 45% opened correctly the airway, 30% checked breathing, 50% gave two breathings, 80% performed 30 compressions, 35% performed compressions in a correct frequency and 60% had performed correct chest place CPR. Concerning the AED use, 30% powered the AED in an appropriated manner and 15% correctly attached the pads but 15% removed the pads after the chock. Conclusion: The results suggest a possible necessity of a continuous CPR and AED training in view of a significant decreasing in the performance of these skills 8 months following the first training course.
Portable liquid oxygen and exercise ability in severe respiratory disability
Authors: Andrew Bush
Journal: Thorax (1993)

cases diagnosed as a result of the contact tracing described in this paper is small, however, and it would be a pity if the possibility of late tuberculosis were discounted on the grounds that no such cases were found in South Glamorgan.We recently reported on a child who was found to have a tuberculous pleural effusion six months after being a close contact of a patient with smear positive tuberculosis.'This child had been thought to be negative on being screened six weeks after the last contact.In children at least, longer follow up may be appropriate.
High Frequency Apparatus: Design, Construction and Practical Application. A Practical Treatise for Electrical Engineers, Electricians, Physicians, Students and Experimenters. Covers the Design and Construction of all Kinds of High Frequency Apparatus for Use in Experimental, Medical and Plant Cultivation Work. Includes also directions for the Construction of a Complete Stage Outfit for Both Low and High Potential Work.
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Modern Aspects of Treatment of Hemophilia. II
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Metabolism and Toxicology of Pyrethroids with Dihalovinyl Substituents
Authors: Luis O. Ruzo, John E. Casida
Journal: Environmental Health Perspectives (1977)

Replacement of the photolabile and biodegradable isobutenyl substituent of pyrethroids with a dihalovinyl group often leads to improved insecticidal potency and enhanced photostability. This type of structural modification does not greatly alter the ease of detoxification in mammals since other sites in the molecule undergo metabolic attack. The available toxicological information on dihalovinyl pyrethroids indicates that they are suitable replacements for other insecticides with less favorable persistence and toxicological characteristics.
"Asplenia"?
Authors: ROBERT W. MOWRY
Journal: Annals of Internal Medicine (1970)

Letters and Comments1 July 1970"Asplenia"?ROBERT W. MOWRY, M.D.ROBERT W. MOWRY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-73-1-140_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Drs. Bisno and Freeman (1) described a patient whose spleen at autopsy was atrophic, weighing only 29 g. Sickle-cell disease is an established cause of splenic atrophy (2). Was sickle-cell disease excluded adequately in this patient? Is it not preferable to reserve the term "asplenia" for those instances in which the spleen is congenitally or surgically absent? "Asplenia" seems needlessly arcane compared with the more appropriate, if mundane, terms such as splenic atrophy, fibrosis, or hyposplenism....References1. BISNO A and FREEMAN J: The syndrome of asplenia, pneumococcal sepsis, and disseminated intravascular coagulation. Ann Intern Med 72:389-393, 1970 LinkGoogle Scholar2. DIGGS L and CHING R: Pathology of sickle cell anemia. Southern Med J 27:839-845, 1934 CrossrefGoogle Scholar1. RODRIGUEZ-ERDMAN F, RUBIN A, and DAMESHEK W: Heparin in thrombotic microangiopathy. Lancet 1:1033, 1966 CrossrefGoogle Scholar2. MERSKY C, JOHNSON A, and KLEINER G: The defibrination syndrome: clinical features and laboratory diagnosis. Brit J Haematol 13:528, 1967 CrossrefMedlineGoogle Scholar1. KABINS S and LERNER C: Fulminant pneumococcemia and sickle cell anemia. JAMA 211:467-471, 1970 CrossrefMedlineGoogle Scholar2. PEARSON H, SPENCER R, and CORNELIUS E: Functional asplenia in sickle-cell anemia. New Eng J Med 281:923-926, 1969 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ROBERT W. MOWRY, M.D.Affiliations: Department of Pathology The Medical Center University of Alabama in Birmingham Birmingham, Ala. 35233 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBibliography – RW MOWRY 1 July 1970Volume 73, Issue 1 Page: 140-141 Keywords Atrophy Autopsy Fibrosis Spleen ePublished: 1 December 2008 Issue Published: 1 July 1970 PDF downloadLoading ...
Cholestasis
Authors: Zeki Karasu, Ilker Turan, Soner Duman, Murat Sozbilen, Omer Unalp, Fulya Gunsar, Galip Ersoz, Angela Papadopoulos-Köhn, Jörg Timm, Guido Gerken, Kerstin Herzer, Stefanie Kluge, Carola Dröge, Dieter Häussinger, Ralf Kubitz
Journal: Hepatology (2013)

MDRD at baseline (MDRD0), 3-month (MDRD3), and 6-month (MDRD6) were: 47.18±10.59,48.06±12.89,and 51.67±12.99,respectively.No statistical difference was found between CrCl0 vs CrCl3, CrCl0 vs CrCl6, and MDRD0 vs MDRD3, but the difference was significant between MDRD0 vs MDRD6 (p=0.017).Of 10 patients who had elevated CK levels underwent electrophysiological tests, 7 patients (18%) diagnosed polyneuropathy (n=5) or myopathy (n=2), with a median duration of 6 (range, 2-9) months after switching to telbivudine.Conclusions: Although telbivudine may provide a promising beneficial effect on renal functions in LT recipients, high polyneuropathy/myopathy rates observed in our study group indicate that it is necessary to be very careful with its use in LT settings.
Anaphylaxis and stinging insect hypersensitivity
Authors: M. D. Valentine
Journal: JAMA (1992)

THE TERM<i>anaphylaxis</i>was coined by the biologists Portier and Richet<sup>1</sup>at the beginning of the 20th century. While guests aboard the yacht of the Prince of Monaco on a Mediterranean cruise, they injected dogs with the toxin of sea anemones in hopes of promoting tolerance to the venom's toxic effects on reinjection. To the contrary, the dogs had more severe reactions on repeat injection. The phenomenon was dubbed<i>anaphylaxis</i>("ana" + "phylaxis" = antiprotection) to denote a state without protection. In the modern era, von Pirquet and Schick,<sup>2</sup>when writing about serum sickness, observed that individuals who developed serum sickness after the administration of heterologous serum antitoxin produced in rabbits or horses, eg, diphtheria antitoxin, were prone to severe, acute reactions when reexposed to a smaller dose of the same serum that caused the original episode of serum sickness. Anaphylaxis is now the term applied to the clinical manifestations
Olfactory meningiomas. The missed diagnosis
Authors: L. Bakay
Journal: JAMA (1984)

Olfactory meningiomas are benign, slow-growing intracranial tumors arising from the dura along the cribriform plate. The first clinical symptom is anosmia followed, usually after several years, by dementia and visual deterioration. A series of 36 patients are presented; in all cases but one, their conditions were diagnosed late and not until the tumor had reached a very large size. By the time the proper diagnosis was made and the tumors were surgically removed, mental or visual disability was often irreversible. Conditions of patients initially seen with anosmia should be investigated by presently available noninvasive diagnostic methods including computed tomographic scanning. (<i>JAMA</i>1984;251:53-55)
Pharmacodynamic phase I study using FLT PET/CT in advanced solid malignancies treated with a sequential combination of X-82 and docetaxel.
Authors: Gil Edward Harmon, Murtuza M. Rampurwala, Matt Scarpelli, Jens C. Eickhoff, Lakeesha Carmichael, Jill Kolesar, Kimberly Binger, Jennifer Heideman, Scott Perlman, Chris Liang, Gary Dukart, Robert Jeraj, Glenn Liu, Justine Yang Bruce
Journal: Journal of Clinical Oncology (2017)

e14088 Background: Increased tumor proliferation has been observed during withdrawal of anti-angiogenic therapy, known as withdrawal flare, which has been demonstrated using [18-F] fluorothymidine [FLT] PET/CT . Sequencing chemotherapy may increase therapeutic window by better synchronizing treatment with tumor proliferation during the flare. This study utilizes FLT PET/CT to assess X-82, a novel VEGFR TKI, used in sequence with docetaxel. Methods: Pts with at least 1 lesion evaluable with FLT PET/CT underwent 21-day treatment cycles with X-82 daily on days 2-15. Starting in cycle 2 (C2), docetaxel was given on day 1 of each cycle. FLT PET/CTs were obtained on days 1 and 15 in cycles 1 and 2. Tumors were identified by a nuclear medicine physician and manually segmented. The maximum tumor FLT uptake SUV max and the total tumor FLT uptake SUV total were extracted for each tumor. To quantify changes in tumor FLT uptake, SUVs were log transformed and included in mixed effects models with random effects accounting for intrapatient correlation of tumor responses. Results: 14 pts were treated with median 3.5 cycles (range 0-12). 4 pts with 13 metastatic tumors completed all PET scans and were included in the pharmacodynamic assessment. 1 pt had an unconfirmed PR and 7 pts had stable disease per RECIST 1.1. The mean percent (%) change in tumor SUV during C1 (X-82 monotherapy) was -13% for SUV max (P = 0.04) and -17% for SUV total (P = 0.14). The mean % change in tumor SUV during C2 (X-82 + docetaxel) was -44% for SUV max (P = 0.03) and -59% for SUV total (P &lt; 0.01). There was a significantly greater decrease in SUV in C2 than in C1 for both SUV max (P = 0.03) and SUV total (P = 0.02). Ten grade 3 AEs possibly related to X-82 were noted in 6 pts, including infections, cytopenias, and vascular complications. Conclusions: Diminished tumor proliferation was observed during X-82 treatment, indicating successful targeting of VEGFRs. Sequential combination of X-82 plus docetaxel showed greater decreases in tumor proliferation compared to X-82 monotherapy indicating value in sequencing chemotherapy during VEGFR TKI treatment breaks. There is evidence that combination therapy is both safe and effective. Clinical trial information: NCT 02146222.
Medical Economics
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Toxicity of podophyllum.
Authors: P Daggem
Journal: BMJ (1972)

sH mEDICAL jouRNAL 16 smm 1972 interpret.Ultrasound detects bowel move--ment because the bowel wall in peristalsis presents a moving iterface which "modu- lates" the beam of ulrasond, which is then converted to sound.The results are qualitative but they provide the important information on whether bowel activity is present.The technique is easily applicable to con- valescent patients, is simple to interpret, and in this series provided reliable and useful information.Ultrasound can be a useful additional tool in the assessment of the silent abdomen.-Iam, etc.,
Resident Forum
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Isolation and enrichment of two sublobular compartment-specific endothelial cell subpopulations from liver sinusoids
Authors: F Vidal-Vanaclocha
Journal: Hepatology (1993)

Similar to the well-recognized phenotypical heterogeneity of hepatocytes, in situ sublobular variations have recently been detected in the cell structure, fenestration patterns, filtrating efficiency, surface glycosylation, scavenger function and pathological responses of the sinusoidal lining endothelium. However, unlike other liver cell populations, until now no endothelial cell subpopulations had been isolated or defined with clarity, much less with sublobular/acinar zone-related differential properties. On the basis of our previous studies showing that periportal segments of mouse liver sinusoids express a significantly higher number of wheat germ agglutinin–binding sites than do perivenous ones, we used this differential feature for in vitro labeling of the specific sublobular derivation of isolated sinusoidal lining endothelial cells to correlate their original lobular position with other features determined on flow cytometry, centrifugal elutriation, discontinuous arabinogalactan density gradients and electron microscopy. Our results revealed additional heterogeneous properties whose association with high or low wheat germ agglutinin–binding capacity made it possible to define in vitro two dominant endothelial cell subpopulations that appear similar to the differential features in the periportal and perivenous sinusoidal segments. Type 1 endothelial cells had low forward angle light scatter and high integrated side scatter, low cytoplasmic porosity index (12% ± 5%) and high wheat germ agglutinin–binding efficiency (160 ± 35 fluorescence intensity units/cell size); these findings are similar to what was observed in situ in the periportal sinusoidal endothelium. On the other hand, type 2 endothelial cells, with high forward angle light scatter and low integrated side scatter, had a high cytoplasmic porosity index (25% ± 8%) and low wheat germ agglutinin–binding efficiency (60 ± 15 fluorescence intensity units/cell size), findings similar to in situ observations of the perivenous sinusoidal lining endothelium. Moreover, these physical and morphological differences entail different cell sedimentation behaviors: type 1 endothelial cell sedimented at high centrifugal elutriation counterflow rates (23 to 37 ml/min) and high arabinogalactan density gradient levels (10% to 15%), whereas type 2 endothelial cell sedimented at low counterflow rates (18 to 23 ml/min) and low density levels (6% to 10%). The combination of these separation procedures made it possible to isolate a 90%-enriched type 1 endothelial cell population in the 12% to 15% interphase of the 23 and 37 ml/min elutriation flow rates and a 75%-enriched type 2 endothelial cell population in the 6% to 10% interphase of the 18 and 23 ml/min flow rates. (HEPATOLOGY 1993;18:328–339).