tbuckley/cabot-search huggingface dataset:
Diagnosis with Wood's light. II. The porphyrias
Authors: K. M. Halprin
Journal: JAMA (1967)

In this article I shall discuss the usefulness of the long-wavelength ultraviolet light emitted by the Wood's light in the diagnosis of several forms of porphyria. The porphyrias are a group of disorders due to abnormalities in the production of the protoporphyrin part of the heme molecule ( heme = protoporphyrin + iron). In all forms of the disease, excessive amounts of one or more of the various precursors of protoporphyrin or of protoporphyrin itself are produced. In acute intermittent porphyria, which is characterized by neurological complaints, the earliest precursors ( δ-aminolevulinic acid and porphobilinogen) are excreted in the urine. These compounds have not yet become porphyrins and do not fluoresce. The patients are not sensitive to sunlight. All other forms of porphyria are characterized by sun sensitivity and the presence of porphyrin compounds in serum and tissues in elevated amounts. Porphyrins absorb long-wavelength ultraviolet light (4,000 Angstrom) and emit light of a longer
From the NIH
Journal: JAMA (1979)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Notes from the Field: National Shortage of Isoniazid 300 mg Tablets
Journal: JAMA (2013)

On November 16, 2012, the Illinois State tuberculosis (TB) program notified CDC's Division of Tuberculosis Elimination of a national shortage of 300 mg tablets of the antituberculosis medication isoniazid (INH). Subsequently, other state TB programs (e.g., California, Indiana, Maryland, New York, Virginia, and Wisconsin) reported difficulty obtaining INH 300 mg tablets. Other programs (e.g., San Diego) have experienced difficulties obtaining at least one of the commercially available anti-TB preparations containing the combination of rifampin and INH (IsonaRif [VersaPharm]).
Atypical melanoma
Authors: S. Baron, V. Goulden, G. Stables
Journal: Journal of the Royal Society of Medicine (2003)

be used for prophylaxis if started 24 hours or more after the acute admission.In the case described here, cerebral haemorrhage worsened when a low-molecular-weight heparin was given a week after the original injury-and there were no apparent aggravating factors such as clotting derangements or sepsis.Although the aim was therapeutic rather than prophylactic (pulmonary embolism was suspected), the case does illustrate the hazards of these agents.Most of the published evidence on anticoagulation in headinjured patients is retrospective and thus insecure.For prophylaxis at least, until better evidence emerges, we would favour mechanical measures (antiembolism stockings, intermittent calf compression, physiotherapy) rather than heparins.
THE ETIOLOGY OF DENGUE FEVER
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
NEAR FOCUS NARROW BAND IMAGING DRIVEN ARTIFICIAL INTELLIGENCE FOR THE DIAGNOSIS OF GASTROESOPHAGEAL REFLUX DISEASE
Authors: S Gulati, J Bernth, J Liao, D Poliyivets, S Chatu, A Emmanuel, A Haji, H Liu, B Hayee
Journal: Endoscopy (2019)

To develop a near focus (NF-NBI) driven artificial intelligence (AI) model for the diagnosis of Gastoesophageal Reflux Disease (GERD).
Hospital Grounds to be Bisected.—
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TUBERCULAR INFECTION BY MILK.
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A CASE OF BILATERAL DISLOCATION OF THE HIP JOINT
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A constant ratio air-oxygen mixer
Authors: P. A. Drinker
Journal: JAMA (1967)

A new device has been developed which delivers regulated oxygen mixtures for use in respiratory therapy. The device is simple and compact for use at the bedside, and is compatible with all respirators and other gas delivery techniques. A single manual control allows selection of 100% oxygen or either of two intermediate mixture ratios. These mixtures are constant with changing ventilatory rates, and the system requires no monitoring or metering of the input gases.
Probable Variant Creutzfeldt-Jakob Disease in a US Resident--Florida, 2002
Journal: JAMA (2002)

On April 18, 2002, the Florida Department of Health and CDC announced the occurrence of a likely case of variant Creutzfeldt-Jakob disease (vCJD) in a Florida resident aged 22 years. This report documents the investigation of this case and underscores the importance of physicians increasing their suspicion for vCJD in patients presenting with clinical features described in this report who have spent time in areas in which bovine spongiform encephalopathy (BSE) is endemic.
WALTER TYRRELL, M.R.C.S
Journal: BMJ (1931)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following WALTER TYRRELL, M.R.C.S Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
From the NIH: Immune interferon in blood may aid in diagnosing active autoimmune disease
Journal: JAMA (1980)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Neuron-Derived Orphan Receptor-1 (NOR-1) Modulates Vascular Smooth Muscle Cell Proliferation
Authors: José Martínez-González, Jordi Rius, Ana Castelló, Claudia Cases-Langhoff, Lina Badimon
Journal: Circulation Research (2003)

Vascular smooth muscle cells (VSMCs) migration and proliferation play a key role in the pathophysiology of cardiovascular disease. However, the transcription factors that regulate VSMC activation are not completely characterized. By a mRNA-differential display approach, we have identified neuron-derived orphan receptor-1 (NOR-1), a transcription factor within the NGFI-B subfamily of nuclear receptors, as a immediate-early gene in VSMCs. Two NOR-1 isoforms (alpha and beta) were identified and cloned from serum-induced porcine VSMC that shared high homology with the human isoforms. Northern blot analysis revealed a strong and transient (1 to 6 hours) upregulation of NOR-1 in both porcine and human coronary SMCs by growth factors (serum, platelet-derived growth factor-BB, and epidermal growth factor) and alpha-thrombin but not by cytokines. NOR-1 upregulation is processed through G protein-coupled receptors and tyrosine kinase receptors, and involves Ca2+ mobilization, protein kinase C activation, and the mitogen-activated protein kinase pathway. This induction was closely dependent of the cAMP response elements present in NOR-1 promoter as transfection assays indicate. Human coronary atherosclerotic lesions overexpress NOR-1, and balloon angioplasty transiently induces NOR-1 in porcine coronary arteries with a pattern similar to that observed in VSMCs in culture. Antisense oligonucleotides against NOR-1 inhibited human coronary SMC proliferation (reduced de novo DNA synthesis, cell cycle progression, and VSMC wound repair) as efficiently as antisense against the protooncogene c-fos. These results show that NOR-1 modulates VSMC proliferation, and suggest that this transcription factor may play a role in both spontaneous and accelerated atherosclerosis.
Neurology
Authors: Donald J. Dalessio
Journal: JAMA (1979)

My concepts of neurology are based on the thesis that neurology is a branch of medicine (as opposed to surgery) and that it will flourish best in a situation where it is closely allied to internal medicine. Some neurological diseases (particularly stroke, headache, and movement disorders) occur with great frequency in the population, are a part of every clinician's experience, and still may produce devastating illness. Several studies dealing with these areas have been published in the past year, and because I consider them to be of interest to the medical community as a whole, I have chosen them for review. <h3>Stroke</h3> Toole and his association<sup>1</sup>provided a comprehensive study of 225 patients with transient ischemic attacks (TIAs) due primarily to atherosclerosis. The patients were followed up for periods of from 3 to 14 years (average, 5.5 years). For study purposes the patients were separated into three groups, untreated,
Subtypes of Australia Antigen and Hepatitis-B Virus
Authors: George L. Le Bouvier
Journal: JAMA (1972)

Infection with type-B-hepatitis virus causes Australia antigen (HB Ag) to appear in the serum. This antigen possesses the "group" specificity,<i>a</i>, common to all HB Ag-positive sera; and one or other of two mutually exclusive subspecificities,<i>d</i>or<i>y</i>, which distinguish the two antigenic subtypes, D and Y. We hypothesize that these determinants,<i>d</i>and<i>y</i>, reflect the activity of two distinct genotypes of hepatitis-B virus (HBV), provisionally designated HBV-D and HBV-Y. Transmission experiments have shown that these viral subtypes "breed true." Their separate identity is further attested by the usual finding of only one subtype in localized outbreaks of hepatitis B. The clinical expressions of HBV-D and HBV-Y infection are beginning to be studied. Early results suggest significant differences in subtype distribution, such as the marked preponderance of Y in drug-abusers' hepatitis.
RET Inhibitor Prompts Roche–Blueprint Alliance
Journal: Cancer Discovery (2020)

Abstract Blueprint Medicines entered into a strategic partnership with Roche to jointly develop and commercialize pralsetinib, a targeted agent for RET-driven malignancies. If pralsetinib is approved, Roche's vast commercial network and diagnostic abilities could help the drug compete against another RET inhibitor, Eli Lilly's selpercatinib, which was approved in May.
Comparative analysis of durable responders on immune checkpoint inhibitors (ICI) versus other systemic therapies: A meta-analysis of phase III trials.
Authors: Elvire Pons-Tostivint, Aurélien Latouche, Pauline Vaflard, Francesco Ricci, Delphine Loirat, Marie-Paule Sablin, Roman Rouzier, Maud Kamal, Claire Morel, Charlotte Lecerf, Vincent Servois, Christophe Le Tourneau
Journal: Journal of Clinical Oncology (2018)

3070 Background: Durable responses have been reported with ICI. We aimed at quantifying the proportion of patients experiencing a durable response on ICI, and comparing it to the proportion observed with other systemic therapies including targeted therapy and chemotherapy. Methods: We retrieved all phase III trials that included at least one ICI arm. The proportion of durable responders was evaluated for each treatment arm by estimating the proportion of patients who had a progression-free survival (PFS) exceeding 3 times the median PFS. The proportion of patients who experienced an overall survival (OS) that exceeded 2 times the median OS was also estimated in each arm, from the published survival curves. The impact of the tumor type and the line of treatment were evaluated. Groups were compared using the Mann-Whitney test. Results: 20 phase III trials involving 12,834 pts (8275 in ICI arms) treated for 8 different types of cancer in 44 treatment arms were retrieved. Median follow up was 15 months [range: 5.6-36.6]. Treatment was ICI alone, chemotherapy, a tyrosine kinase inhibitor, a vaccine, a placebo and ICI + chemotherapy in 24 (54.5%), 13 (29.5%), 1 (2.3%), 1 (2.3%), 2 (4.5%), and 3 (7%) arms. The mean median PFS was 3.8 [95%CI: 3-4.7] vs 3.5 months [95%CI: 2.9-4.1] in the ICI alone arm and in the control arms. Mean median OS was 13.9 [95%CI: 10.6-17.2] vs 9.7 months [95%CI: 7.8-11.6] in the ICI alone arm and in the control arms (p = 0.01). The proportion of patients who experienced a durable response defined as a PFS exceeding 3 times the median PFS was 24.6% [95%CI:20.9-28.3] vs 11% [95%CI:8.5-13.5] in the ICI alone and control arms, respectively (p < 0.0001). The proportion of patients who survived longer than 2 times the median OS was 29.7% [95%CI: 28-31.3] in the ICI alone group vs 21.8% [95%CI: 19.4-24.2] in the control group (p < 0.0001). The effect was similar even in patients treated beyond the first-line metastatic setting and in non-melanoma tumor types. Conclusions: The proportion of patients experiencing a durable response was more than twice higher on ICI than on other treatments, even in patients treated beyond the first-line metastatic setting and in non-melanoma tumor types.
Low HBcrAg and HBsAg levels identify patients most likely to achieve sustained response after nucleos(t)ide analogue cessation: results from a global individual patient data meta-analysis (create study)
Authors: Milan Sonneveld, Jun Yong Park, Wai-Kay Seto, Yasuhito Tanaka, Ivana Carey, Margarita Papatheodoridi, Fabien Zoulim, Sang Hoon Ahn, George Dalekos, Christoph Hoener zu Siederdissen, Markus Cornberg, Man-Fung Yuen, Kosh Agarwal, Andre Boonstra, Maria Buti, George Papatheodoridis, Benjamin Maasoumy
Journal: Journal of Hepatology (2020)
Nuclear war must not be fought—so our 'SAC warriors' will stay on alert
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Vitamin B Complex
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal