tbuckley/cabot-search huggingface dataset:
Two-year follow up results of a population-based prospective case control study of 143 stage IV colorectal cancer (CRC) patients treated with 2nd line irinotecan (iri) outside of clinical trial
Authors: I. Lang, E. Hitre, Z. Horvath
Journal: Journal of Clinical Oncology (2004)

3687 Background: 2nd line iri treatment for stage for CRC has been financed by the Hungarian Natiional Insurance Company since 2001. This therapy was found to be active in clinical trials as compared to BSC and in 5-FU treated patients. Our aim was to evaluate its effect in compassionate use in the Hungarian population. Methods: All data of the patients (>70 yr, ECOG 0–2, no brain metastasis) were reported to an independent committee prior to iri treatment, after every 2nd cycle up 6 cycles and then every six months until death. First-line chemotherapy was bolus or infusional 5-FU-Leucovorin. 62 patients had rectal cancer, 79 had colon cancer. Primary tumor was resected in 124 cases. Fifty eight % received monotherapy (350 mg/m2 q3 weeks, the rest received FOLFIRI combination (180 mg/m2 iri q2 weeks). 52,6% had liver metastases, 22,4 % had lung metastases. Results: 29,8% ORR, (CR 4%, PR 25,8%), and 61,4% SD was found. TTP was 7,41 ± 6,14 months. OS: 11,67 ± 7,2 months, mOS:11,2 month. At a two years follow-up time 35 out of 143 pts were alive (24,5 %). Median OS was significantly longer if primary tumor was removed (16,77 vs 8,43 months; p=0,0002). Grade III/IV diarrhoea, vomiting and granulocytopenia were around 20 %. Conclusions: In a population-based compassionate setting the efficacy and safety of 2nd line iri therapy was comparable to those found in randomised phase III trials. No significant financial relationships to disclose.
Temsirolimus in Combination with Bendamustine and Rituximab for the Treatment of Relapsed Mantle Cell and Follicular Lymphoma: Report on an Ongoing Phase I/II Trial
Authors: Georg Hess, Ulrich Keller, Johannes Atta, Ulrich Bitz, Christian Lerchenmueller, Wagner Karola, Christoph Medler, Christian Ruckes, Mathias Witzens-Harig, Kai Huebel, Paul LaRosee, Martin H. Dreyling
Journal: Blood (2015)
Queries and Minor Notes
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Varicella Myelopathy
Authors: Harry H. White
Journal: New England Journal of Medicine (1962)

VULNERABILITY of involvement of the nervous system in the course of the exanthematous diseases of childhood is well known. Although the exact incidence of neurologic disorders accompanying varicella is uncertain such complications occur less commonly than with measles, mumps, pertussis and scarlet fever.1 It is the purpose of this communication to report an unusual neurologic complication of varicella and to review the previously reported cases with this form of neural involvement.Case ReportA 12-year-old colored girl was admitted to Babies Hospital on June 13, 1961. The past and family histories were not remarkable. Seven days before admission she had . . .
Military rubella
Authors: D. Schlossberg
Journal: JAMA (1977)

An epidemic of rubella in 46 young adults occurred. Detailed descriptions of clinical signs and symptoms, basic laboratory evaluation and serologic investigation are provided. None of the vaccinees who became ill lacked IgM antibody. An interesting clinical observation was the 25% incidence of testicular pain. (<i>JAMA</i>238:1273-1274, 1977)
The impact of diabetes on survival following myocardial infarction in men vs women. The Framingham Study
Authors: R. D. Abbott
Journal: JAMA (1988)

The impact of diabetes on recurrent myocardial infarction (MI) and fatal coronary heart disease was examined in survivors of an initial MI using 34-year follow-up data in the Framingham Study. Among nondiabetic patients, the risk of fatal coronary heart disease was significantly lower in women compared with men (relative risk, 0.6). In the presence of diabetes, however, the risk of recurrent MI in women was twice the risk in men. In addition, the effect of diabetes doubled the risk of recurrent MI in women (relative risk, 2.1) but had an insignificant effect in men. Increased susceptibility to cardiac failure among diabetic women was an important factor in determining survivorship. Women with diabetes developed cardiac failure four times more often (16%) than women without diabetes (3.8%). Furthermore, when cardiac failure developed, 25% of diabetic women experienced a recurrent MI or fatal coronary event, more than doubling the rate when diabetes was absent. We conclude that in the diabetic patient who survives an MI, cardiac failure is a common occurrence, warranting early detection and vigorous management in periods of convalescence and follow-up. In addition, when cardiac failure appears, control of diabetes assumes added importance, particularly in women, where its effect on survivorship is considerable. (<i>JAMA</i>1988;260:3456-3460)
Safety of readministration of abciximab; interim results of the ReoPro readministration registry (R 3 )
Authors: J.E. Tcheng, D.J. Kereiakes, B.S. Georgo, G. Braden, M.A. Langrall, D. Zelinger, R. Jordan, M.B. Effron
Journal: Journal of the American College of Cardiology (1998)
Nivolumab dose selection: challenges, opportunities and lessons learned for cancer immunotherapy
Authors: Shruti Agrawal, Yan Feng, Amit Roy, Georgia Kollia, Brian Lestini
Journal: Journal for ImmunoTherapy of Cancer (2015)

Meeting abstracts Dose selection for immuno-oncology (I-O) treatments presents unique challenges and opportunities. Surrogate efficacy endpoints in early clinical studies (typically objective anti-tumor response) may not fully represent the potential for improved overall survival in pivotal trials
Antiplatelet Agents In The Prevention And Therapy Of Thrombosis
Authors: B. Coller
Journal: Annual Review of Medicine (1992)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease 2019 (COVID-19), emerged in China in December 2019 and quickly spread around the globe, killing more than 4 million people and causing a severe economic crisis. ...Read More
ABO and Rho(D) blood types in patients with multiple primary cancers
Authors: K. E. Holley
Journal: JAMA (1966)

Attempts to associate ABO and other blood types with various disease states have resulted in a large and somewhat controversial literature.<sup>1-6</sup>The necessary requirement of large numbers of patients and appropriate control data has been difficult to meet except for the more common disease states. The review articles of Roberts<sup>7</sup>and of Clarke<sup>8</sup>clearly point out the pitfalls of drawing statistical conclusions from small series of patients. Recently Fadhli and Dominguez<sup>9</sup>reported finding an increased incidence of blood type A among 125 white patients who had multiple primary cancers. It was suggested that the probability of a second primary malignant tumor developing in these patients with blood type A could be considered greater than it was in patients whose blood type was 0, B, or AB. These authors further commented, however, on the need of larger series to confirm their findings. Tsukada and associates<sup>10</sup>were
American Cancer Society Guidelines on Nutrition and Physical Activity for Cancer Prevention: Reducing the Risk of Cancer with Healthy Food Choices and Physical Activity
Authors: T. Byers, M. Nestle, A. McTiernan, C. Doyle, A. Currie-Williams, T. Gansler, M. Thun
Journal: CA A Cancer Journal for Clinicians (2002)

The American Cancer Society (ACS) has set aggressive challenge goals for the nation to decrease cancer incidence and mortality—and to improve the quality of life of cancer survivors—by the year 2015. To address these critical goals, the ACS publishes the Nutrition and Physical Activity Guidelines to serve as a foundation for its communication, policy, and community strategies and ultimately, to affect dietary and physical activity patterns among Americans. These guidelines, published every five years, are developed by a national panel of experts in cancer research, prevention, epidemiology, public health, and policy, and as such, they represent the most current scientific evidence related to dietary and activity patterns and cancer risk. The American Cancer Society guidelines include recommendations for individual choices regarding diet and physical activity patterns, but those choices occur within a community context that either facilitates or interferes with healthy behaviors. Therefore, this committee presents one key recommendation for community action to accompany the four recommendations for individual choices for nutrition and physical activity to reduce cancer risk. This recommendation for community action underscores just how important community measures are to the support of healthy behaviors by means of increasing access to healthful food choices and opportunities to be physically active. The ACS guidelines are consistent with guidelines from the American Heart Association for the prevention of coronary heart disease as well as for general health promotion, as defined by the Department of Health and Human Services' 2000 Dietary Guidelines for Americans.1,2
Anxiety-related reactions associated with magnetic resonance imaging examinations
Authors: J. C. Melendez
Journal: JAMA (1993)

<h3>Objective.</h3> —To review the epidemiology of anxiety-related reactions during magnetic resonance imaging (MRI) examinations, the feasibility of identifying patients at risk, and the management strategies that have been applied. <h3>Data Sources.</h3> —Published original articles were retrieved using computerized MEDLINE searches encompassing 1980 through April 1993. Further references were obtained from the primary sources. <h3>Study Selection and Data Extraction.</h3> —All studies obtained through the data search were chosen for review. All data relevant to anxiety-related reactions were analyzed. <h3>Data Synthesis.</h3> —Anxiety-related reactions occur in approximately 4% to 30% of patients undergoing MRI, ranging from apprehension to severe reactions that interfere with the performance of the test. Criteria for diagnosis or categorization of the reactions and identification of patients at risk are scanty. Several management strategies have been proposed, including patient education, drug therapy, and cognitive-behavioral intervention. <h3>Conclusions.</h3> —While a more precise characterization of the nature and incidence of anxiety-related reactions during MRI examinations and better methods of recognizing patients at risk are desirable, a strategy for general and individual prophylaxis, identification of patients at risk, and individual patient management can be developed on the basis of current knowledge. (<i>JAMA</i>. 1993;270:745-747)
SM-03 * A RANDOMIZED, PLACEBO-CONTROLLED PILOT TRIAL OF ARMODAFINIL FOR FATIGUE IN PATIENTS WITH GLIOMAS UNDERGOING RADIOTHERAPY
Authors: E. Lee, A. Muzikansky, S. Kesari, E. Wong, C. Fadul, D. Reardon, A. Norden, L. Nayak, M. Rinne, B. Alexander, N. Arvold, L. Doherty, D. LaFrankie, J. Pulverenti, K. Smith, S. Gaffey, A. Kenney, S. Hammond, J. Drappatz, P. Wen
Journal: Neuro-Oncology (2014)
Leads from the MMWR. Fansidar-associated fatal reaction in an HIV-infected man
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BILL TO INCREASE THE EFFICIENCY OF THE ARMY MEDICAL CORPS.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE LATE LEPROSY CONGRESS.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Book Review Clinical Pharmacology: An interactive drug reference and teaching guide CD-ROM or diskettes with manual and binder. By Stan Reents and Jon Seymour. System needed: Multimedia IBM PC or compatible, with 37 MB of hard-disk space. (Also available for multimedia Macintosh with at least 27 MB of hard-disk space and 4 MB of RAM.) Gainesville, Fla., Gold Standard Multimedia, 1995. $295 yearly subscription with quarterly updates. 1-885966-07-5
Authors: Eytan Z. Blumenthal, Daniel Mimouni
Journal: New England Journal of Medicine (1996)
Malarial Transfusions
Authors: MARCEL E. CONRAD
Journal: Annals of Internal Medicine (1967)

Editorial Notes1 September 1967Malarial TransfusionsMARCEL E. CONRADMARCEL E. CONRADSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-67-3-676 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe military need to station many soldiers in geographic areas where drug-resistant malaria is endemic has led to an increased prevalence of malaria in the United States. Most physicians have been alerted to the possibility of malaria occurring in returnees from Vietnam but do not suspect this diagnosis in civilians who become febrile days or weeks after blood transfusion (1-3).Accidental transmission of malaria cannot be avoided by blood storage or available laboratory tests of donor blood. Malarial parasites can survive for weeks in banked blood and are difficult to detect in stained thick smears from asymptomatic malarial carriers (4-6)....References1. SHEEHYREBA TWRC: Treatment of chloroquine-resistant Plasmodium falciparum infections in Vietnam. Ann. Intern. Med. 66: 616, 1967. LinkGoogle Scholar2. Resistance of malarial parasites to drugs. WHO Techn. Rep. Ser. 296: 29, 1965. Google Scholar3. CONDITPROCTORFERGUSONISAKSONSTEERBRAFF PKRREPAEH: Blood transfusion induced case of falciparum malaria. Morbidity and Mortality Weekly Report April 15, 1967, p. 119. Google Scholar4. GRANTPERINPANAYAGAMSHUTEZEITLIN DBMSPGRA: A case of malignant tertian (Plasmodium falciparum) malaria after blood-transfusion. Lancet 2: 469, 1960. CrossrefMedlineGoogle Scholar5. BLACK RH: Investigation of blood donors in accidental transfusion malaria—Plasmodium vivax, falciparum and malariae infections. Med. J. Aust. 2: 446, 1960. CrossrefGoogle Scholar6. MOLLISON PL: Blood Transfusion in Clinical Medicine, 4th ed. F. A. Davis Co., Philadelphia, 1967, p. 623. Google Scholar7. SADUNOSBORNE EHHS: Research in malaria. Milit. Med. 131: 847, 1966. CrossrefGoogle Scholar8. Chemotherapy of malaria. WHO Monogr. Ser. 27, 1955. Google Scholar9. HUNTERFRYESWARTZWELDER GWWWJC: A Manual of Tropical Medicine, 4th ed. W. B. Saunders Co., Philadelphia, 1966, p. 334. Google Scholar10. Technical Methods and Procedures of the American Association of Blood Banks, 4th ed. American Association of Blood Banks, Chicago, 1966, p. 9. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byINFECTION WITH CHLOROQUINE-RESISTANT PLASMODIUM FALCIPARUM IN MAN: PREPATENT PERIODS, INCUBATION PERIODS, AND RELATIONSHIPS BETWEEN PARASITEMIA AND THE ONSET OF FEVER IN NONIMMUNE PERSONSMalaria in Vietnam Veterans 1 September 1967Volume 67, Issue 3_Part_1Page: 676-677KeywordsArmed forcesBloodBlood banksBlood donorsBlood transfusionDrugsGeographic areasHematologic testsLaboratory testsMalaria Issue Published: 1 September 1967 PDF downloadLoading ...
Manual of Splints and Appliances for the Medical Department of the United States Army.
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
INTEGRATING DETECTION OF COPY NEUTRAL CHROMOSOMAL LOSSES IN A CLINICAL SETTING IN LEUKEMIA AND LYMPHOMA BY MEANS OF ALLELIC IMBALANCE AND READ DEPTH RATIO COMPARISON
Authors: M. C. Hansen, O. Cédile, M. Ludvigsen, E. Kjeldsen, P. L. Møller, N. Abildgaard, P. Hokland, C. G. Nyvold
Journal: HemaSphere (2019)
Medical Education, Registration and Hospital Service
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
IPPB
Authors: F. Roger Smith
Journal: JAMA (1975)

<h3>To the Editor.—</h3> The commentary, "The Indiscriminate Use of IPPB" (231:1141, 1975) implies that the staff of a respiratory therapy department may be incompetent. I am sorry that Drs Barach and Segal work in an institution where the respiratory therapy staff find hand bulb nebulizers, spontaneous coughing, and deep breathing as "inappropriate and old fashioned." This respiratory therapy staff is not representative of all in the United States. A staff of professional respiratory therapists owe it to their patients to utilize the most beneficial and least expensive methods for treatment of physiological disorders. This type of staff often approaches the physician with recommendations for discontinuance of the use of IPPB and implementation of coughing and deep breathing techniques. This does not rule out IPPB as an effective modality in the treatment of patients that cannot, for a variety of reasons, effectively cough and deep breathe. The use of IPPB may