tbuckley/cabot-search huggingface dataset:
Long-term pervenous atrial pacing from the proximal portion of the coronary vein
Authors: A. J. Moss
Journal: JAMA (1969)

Long-term left atrial pacing was successfully accomplished in three patients by positioning permanently implanted pervenous pacemaker catheters in the proximal portion of the coronary vein. Left atrial stimulation was documented by the configuration of the P waves on the electrocardiogram—the P waves were inverted in leads I and V<sub>6</sub>and upright in V<sub>1</sub>. Roentgenograms of the chest revealed that the pacemaker electrodes were located inferiorly and posteriorly to the left atrium. In one patient, angiocardiography was used to document the position of the catheter in the coronary vein. One patient died of causes unrelated to the pacemaker one month after implantation, and the catheter tip was located in the coronary vein which was not thrombosed. The other two patients are doing well 13 and 18 months, respectively, after pacemaker placement, and consistent and stable atrial pacing has continued throughout this period of time.
Essential fatty acids in the plasma phospholipids of patients with atopic cataracts
Authors: M.F. MUHLEMANN, M.S. MANKU, T.J.K. LEONARD, J.J. CREAM
Journal: British Journal of Dermatology (1987)

Abnormal levels of the essential fatty acids (EFA) in plasma phospholipids have been reported in atopic dermatitis. We have compared EFA levels in 10 patients with atopic cataracts and 29 atopic dermatitis patients without cataracts and found no 0significant differences, with the exception that higher levels of adrenic acid occurred in those with cataracts.
Effect of Stanozolol on Liver Function
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The olympic games
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diseases of Nerves
Authors: James F. Toole
Journal: JAMA (1971)

Here is another of the projected 30 volumes of the<i>Handbook of Clinical Neurology</i>. This and its companion volume, part 1, undoubtedly will constitute the definitive work on the subject for years to come. Part 2 begins with chapters on affectations of peripheral nerves caused by metabolic, dysproteinemic, and endocrine disorders and will be of interest to specialists in those fields. In Chapter 9, "Peripheral Neuropathy Associated with Malignant Disease," Henson and Urich continue the debate and document convincingly their contention that certain neoplasms exert an indirect effect on sensory and motor nerves, resulting in neuropathy. Taking the London Hospital as their criterion (a debatable point because of a probable bias in case selection caused by their well-known interest in the subject), they suggest that the syndrome is much more common than is commonly believed, and they cite statistics to prove it. This wealth of clinical detail makes fascinating reading
CODE OF MEDICAL ETHICS.WHERE AND HOW SHALL THE MEDICAL STUDENT GET INFORMATION CONCERNING MEDICAL ETHICS?
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Air Pollution and Daily Mortality in Seoul and Ulsan, Korea
Authors: Jong-Tae Lee, Dongchun Shin, Yong Chung
Journal: Environmental Health Perspectives (1999)

The relationship between air pollution and daily mortality for the period 1991-1995 was examined in two Korean cities, Seoul and Ulsan. The observed concentrations of sulfur dioxide (SO2; mean = 28.7 ppb), ozone (O3; mean = 29.2 ppb), and total suspended particulates (TSP; mean = 82.3 microg/m3) during the study period were at levels below Korea's current ambient air quality standards. Daily death counts were regressed separately in the two cities, using Poisson regression on SO2, O3, and/or TSP controlling for variability in the weather and seasons. When considered singly in Poisson regression models controlling for seasonal variations and weather conditions, the nonaccidental mortality associated with a 50-ppb increment in a 3-day moving average of SO2 concentrations, including the concurrent day and the preceding 2 days, was 1.078 [95% confidence interval (CI), 1.057-1.099] for Seoul and 1.051 (CI, 0.991-1.115) for Ulsan. The rate ratio was 1.051 (CI, 1.031-1.072) in Seoul and 0.999 (CI, 0. 961-1.039) in Ulsan per 100 microg/m3 for TSP, and 1.015 (CI, 1. 005-1.025) in Seoul and 1.020 (0.889-1.170) in Ulsan per 50 ppb for 1-hr maximum O3. When TSP was considered simultaneously with other pollutants, the TSP association was no longer significant. We observed independent pollution effects on daily mortality even after using various approaches to control for either weather or seasonal variables in the regression model. This study demonstrated increased mortality associated with air pollution at both SO2 and O3 levels below the current World Health Organization recommendations.
Acute Suffocative Pulmonary Oedema
Journal: BMJ (1926)

Acute pulmonary ae dema may be defined as a morbid syndrome constituted by a sudden serous transudation from the lung-eapillaries into the pulmonary interstices, alveoli and bronchioles.This serous inundation of the cavities of the lungs impedes the respiratory function and may become an obstacle to the pulmonary circulation by compressing the capillaries.The resulting severe dyspnoe a with the feeling of impending suffocation accounts for the designation of "Acute suffocative pulmonary ® dema* as usually applied to the condition in this country.This form of title appears to have been first employed by Dr. (afterwards Professor) Lindsay Steven in a clinical lecture delivered by him in the Glasgow Royal Infirmary on
Ginseng and Warfarin Interactions
Authors: Chun-Su Yuan
Journal: Annals of Internal Medicine (2004)

Letters7 December 2004Ginseng and Warfarin InteractionsChun-Su Yuan, MD, PhDChun-Su Yuan, MD, PhDFrom Tang Center for Herbal Medicine Research, University of Chicago, Chicago, IL 60635.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-141-11-200412070-00031 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We appreciate the comments of Dr. Plotnikoff and his colleagues. Their letter addresses important issues that warrant clarification and further discussion.Our data showed that American ginseng (Panax quinquefolius L.), a commonly used herb in the United States, reduces the anticoagulant effect of warfarin. Limitations on the length of our article prevented us from providing information about other types of ginseng, which were discussed in our previous publications (1, 2). We did not extrapolate our data on American ginseng to other species of ginseng. Our study, however, provides an example of drug–herbal interaction. Herbal medicines, such as American ...References1. Attele AS, Wu JA, Yuan CS. Ginseng pharmacology: multiple constituents and multiple actions. Biochem Pharmacol. 1999;58:1685-93. [PMID: 10571242] CrossrefMedlineGoogle Scholar2. Ang-Lee MK, Moss J, Yuan CS. Herbal medicines and perioperative care. JAMA. 2001;286:208-16. [PMID: 11448284] CrossrefMedlineGoogle Scholar3. Assinewe VA, Baum BR, Gagnon D, Arnason JT. Phytochemistry of wild populations of Panax quinquefolius L. (North American Ginseng). J Agric Food Chem. 2003;51:4549-53. [PMID: 14705875] CrossrefMedlineGoogle Scholar4. Harkey MR, Henderson GL, Gershwin ME, Stern JS, Hackman RM. Variability in commercial ginseng products: an analysis of 25 preparations. Am J Clin Nutr. 2001;73:1101-6. [PMID: 11382666] CrossrefMedlineGoogle Scholar5. Yuan CS, Wu JA, Osinski J. Ginsenoside variability in American ginseng samples [Letter]. Am J Clin Nutr. 2002;75:600-1. [PMID: 11864869] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Tang Center for Herbal Medicine Research, University of Chicago, Chicago, IL 60635. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoBrief Communication: American Ginseng Reduces Warfarin's Effect in Healthy Patients Chun-Su Yuan , Gang Wei , Lucy Dey , Theodore Karrison , Linda Nahlik , Spring Maleckar , Kristen Kasza , Michael Ang-Lee , and Jonathan Moss Ginseng and Warfarin Interactions Gregory A. Plotnikoff , Dennis McKenna , Kenji Watanabe , and Mark Blumenthal Metrics 7 December 2004Volume 141, Issue 11Page: 894-895KeywordsAttentionClinical trialsDrug interactionsDrug therapyDrugsFallsForecastingHerbal medicineResearch laboratoriesTemperature ePublished: 7 December 2004 Issue Published: 7 December 2004 CopyrightCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
'Rocker-Bottom Thymus'
Authors: Marvin S. Kogutt
Journal: JAMA (1981)

THE OCCURRENCE of pneumomediastinum and pneumothorax in the neonate is relatively common. Pneumomediastinum is secondary to alveolar rupture with dissection of air along the pulmonary interstitium into the mediastinum.<sup>1</sup>This condition usually causes little or no respiratory distress. The classic configuration of pneumomediastinum is caused by elevation of the thymic lobes by air loculated within the anterior mediastinum. Several descriptive terms, including the "angel-wing" or "spinnaker sail" thymus, are well known.<sup>2</sup>Mediastinal air may also enter the subpleural space causing the "extrapleural air sing."<sup>3</sup>This article describes a previously unreported configuration of the thymus in pneumomediastinum. This should not be confused with more serious abnormalities such as mediastinal masses, anomalous vessels, or other pathological structures. <h3>Report of Cases</h3><h3>Case 1.—</h3> A 2,200-g infant was born after a full-term gestation and delivery. The infant was referred to this hospital after experiencing mild respiratory distress, and a chest roentgenogram
Medical Ethics
Authors: Robert M. Veatch
Journal: JAMA (1980)

The 1970s could be said to be the decade when medical ethics came of age. More precisely, perhaps, it was the decade when it came of age once again, for there have been other periods in history when medical ethics flourished as a lively, vibrant field of study and debate. But the 1970s was a decade when a field of scholarly and applied study of important, practical ethical problems in medicine emerged as a serious, sustained endeavor. This evolution paralleled important social events in medicine. <h3>Practical Ethics</h3> At the beginning of the decade, the heart transplant was a new, exciting, and morally challenging procedure. It forced on us debates about the definition of death, the ethics of cadaver organ use, and even the ethics of moving from one human to another the organ that has been thought to be the seat of the soul. It even generated science fiction speculation
Microscopic haematuria
Authors: F. H Schroder
Journal: BMJ (1994)

<h3>BACKGROUND AND PURPOSE:</h3> Intracerebral hemorrhage growth independently predicts disability and death. We hypothesized that noncontrast quantitative CT densitometry reflects active bleeding and improves predictive models of growth. <h3>MATERIALS AND METHODS:</h3> We analyzed 81 of the 96 available baseline CT scans obtained &lt;3 hours post-ICH from the placebo arm of the phase IIb trial of recombinant factor VIIa. Fifteen scans could not be analyzed for technical reasons, but baseline characteristics were not statistically significantly different. Hounsfield unit histograms for each ICH were generated. Analyzed qCTD parameters included the following: mean, SD, coefficient of variation, skewness (distribution asymmetry), and kurtosis (“peakedness” versus “flatness”). These densitometry parameters were examined in statistical models accounting for baseline volume and time-to-scan. <h3>RESULTS:</h3> The coefficient of variation of the ICH attenuation was the most significant individual predictor of hematoma growth (adjusted <i>R</i><sup>2</sup> = 0.107, <i>P</i> = .002), superior to BV (adjusted <i>R</i><sup>2</sup> = 0.08, <i>P</i> = .006) or TTS (adjusted <i>R</i><sup>2</sup> = 0.03, <i>P</i> = .05). The most significant combined model incorporated coefficient of variation, BV, and TTS (adjusted <i>R</i><sup>2</sup> = 0.202, <i>P</i> = .009 for coefficient of variation) compared with BV and TTS alone (adjusted <i>R</i><sup>2</sup> = 0.115, <i>P</i> &lt; .05). qCTD increased the number of growth predictions within ±1 mL of actual 24-hour growth by up to 47%. <h3>CONCLUSIONS:</h3> Heterogeneous ICH attenuation on hyperacute (&lt;3 hours) CT imaging is predictive of subsequent hematoma expansion and may reflect an active bleeding process. Further studies are required to determine whether qCTD can be incorporated into standard imaging protocols for predicting ICH growth.
Low Back Pain
Authors: A. B. Coyer, I. H. M. Curwen
Journal: BMJ (1955)

During HIV-1 particle formation, the requisite plasma membrane curvature is thought to be solely driven by the retroviral Gag protein. Here, we reveal that the cellular I-BAR protein IRSp53 is required for the progression of HIV-1 membrane curvature to complete particle assembly. Partial gene editing of IRSp53 induces a decrease in viral particle production and a viral bud arrest at half completion. Single molecule localization microscopy at the cell plasma membrane shows a preferential localization of IRSp53 around HIV-1 Gag assembly sites. In addition, we observe the presence of IRSp53 in purified HIV-1 particles. Finally, HIV-1 Gag protein localizes preferentially to IRSp53 I-BAR domain induced curved membranes on giant unilamellar vesicles. Overall, our data reveal a strong interplay between IRSp53 I-BAR and Gag at membranes during virus assembly. This highlights IRSp53 as a crucial host factor in HIV-1 membrane curvature and its requirement for full HIV-1 particle assembly.
Epidemiology in Action Course
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Health Effects of Particulate Air Pollution: Time for Reassessment?
Authors: C. Arden Pope, David V. Bates, Mark E. Raizenne
Journal: Environmental Health Perspectives (1995)

Numerous studies have observed health effects of particulate air pollution. Compared to early studies that focused on severe air pollution episodes, recent studies are more relevant to understanding health effects of pollution at levels common to contemporary cities in the developed world. We review recent epidemiologic studies that evaluated health effects of particulate air pollution and conclude that respirable particulate air pollution is likely an important contributing factor to respiratory disease. Observed health effects include increased respiratory symptoms, decreased lung function, increased hospitalizations and other health care visits for respiratory and cardiovascular disease, increased respiratory morbidity as measured by absenteeism from work or school or other restrictions in activity, and increased cardiopulmonary disease mortality. These health effects are observed at levels common to many U.S. cities including levels below current U.S. National Ambient Air Quality Standards for particulate air pollution.
The Neurological Practice of Medicine. A Cursory Course of Selected Lectures in Neurology, Neuriatry, Psychology and Psychiatry. Applicable to General and Special Practice. With 177 Illustrations. After the Author's Class-Room Methods as a Teacher of Students. Designed for Students and General Practitioners of Medicine and Surgery.
Journal: JAMA (1903)

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ALIMENTARY FACTORS INFLUENCING ABSORPTION OF CALCIUM AND PHOSPHORUS
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Regulation of rat liver S-adenosylmethionine synthetase during septic shock: Role of nitric oxide
Authors: M Avila
Journal: Hepatology (1997)

We investigated the modulation of rat liver S-adenosylmethionine (SAM) synthetase in a model of acute sepsis. Our results show that animals treated with bacterial lipopolysaccharide experience a marked decrease in liver SAM synthetase activity. No changes were detected in the hepatic levels of SAM synthetase protein, suggesting that inactivation of the existing enzyme was the cause of the observed activity loss. Lipopolysaccharide treatment resulted in the expression of calcium-independent/cytokine-inducible nitric oxide (NO) synthase in liver and the accumulation in plasma of the NO-derived species nitrite and nitrate. NO implication in the in vivo regulation of SAM synthetase was evaluated in animals treated with the NO donor molecule 3-morpholinosydnonimine. The analysis of liver enzymatic activity, along with protein and messenger RNA levels yielded results similar to those obtained with lipopolysaccharide treatment. To assess directly the sensitivity of SAM synthetase to NO, the rat liver-purified high- and low-molecular weight forms of the enzyme were exposed to various doses of 3-morpholinosydnonimine and other NO donors such as S-nitroso-N-acetylpenicillamine, resulting in a dose-dependent inhibition of enzymatic activity. This effect was reversed by addition of the reducing agents beta-mercaptoethanol and glutathione. Finally, cysteine 121 was identified as the site of molecular interaction between NO and rat liver SAM synthetase that is responsible for the inhibition of the enzyme. To reach this conclusion, the 10 cysteine residues of the enzyme were changed to serine by site-directed mutagenesis, and the effect of NO on the various recombinant enzymes was measured. (Hepatology 1997 Feb;25(2):391-6)