tbuckley/cabot-search huggingface dataset:
Healthful Living
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Thyroid asymmetry.
Authors: J. D. Wiener, P. Roos
Journal: BMJ (1968)

<h3></h3> Worldwide, women face sexual and reproductive health (SRH) risks including unintended pregnancy and sexually transmitted infections (STIs) including HIV. Multipurpose prevention technologies (MPTs) combine protection against two or more SRH risks into one product. Male and female condoms are the only currently available MPT products, but several other forms of MPTs are in development. We conducted a comprehensive analysis to examine the global distribution of selected SRH issues to determine where various risks have the greatest geographical overlap. We examined four indicators relevant to MPTs in development: HIV prevalence, herpes simplex virus type 2 (HSV-2) prevalence, human papillomavirus (HPV) prevalence, and the proportion of women with unmet need for modern contraception. Using ArcGIS Desktop, we mapped these indicators individually and in combination on chloropleth and graduated symbol maps. We conducted a principal components analysis to reduce data and enable visual mapping of all four indicators on one graphic to identify overlap. Our findings document the greatest overlapping risks in sub-Saharan Africa, and we specify countries in greatest need by specific MPT indication. These results can inform strategic planning for MPT introduction, market segmentation, and demand generation, but data limitations also highlight the need for improved (non-HIV) STI surveillance globally.
Hypertension
Authors: James Brian Byrd, Robert D. Brook
Journal: Annals of Internal Medicine (2019)

Recent guidelines on diagnosis and management of high blood pressure (BP) include substantial changes and several new concepts compared with previous guidelines. These are reviewed and their clinical implications are discussed in this article. The goal is to provide a practical reference to assist clinicians with up-to-date management of patients with high BP. Important issues include new diagnostic thresholds, out-of-office BP monitoring, intensified treatment goals, and a different approach to resistant hypertension. Finally, differences among guidelines, the persistent controversies that have led to them, and their implications for clinical practice are discussed.
Suspected Nosocomial Influenza Cases in an Intensive Care Unit—Georgia
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Congress wants alternative therapies studied; NIH responds with programs
Authors: C. Marwick
Journal: JAMA (1992)

WITH CONGRESS prodding, the National Institutes of Health (NIH) is preparing to support studies evaluating some alternative therapeutic approaches. In passing the 1992 appropriations legislation, Congress requested that the institutes look into alternative approaches and provided about $2 million for this purpose. (The NIH's total budget for this year is about $8.9 billion.) <h3>New NIH Office</h3> Using the $2 million appropriation to get started, the NIH's director, Bernadine Healy, MD, has created the Office for the Study of Unconventional Medical Practices. The office, under the direction of Stephen C. Groft, PharmD, is charged with evaluating acupuncture, so-called folk remedies, use of herbs, homeopathy, naturopathy, nutritional treatments, massage therapy, and other practices that are, in general, presently considered by some to be outside mainstream therapy or patient management in this country. The NIH already has called together some 20 persons with widely diverse interests in unconventional practices. This ad hoc committee,
"Do not resuscitate" orders. Ensuring the patient's participation
Authors: R. L. Stephens
Journal: JAMA (1986)

A RECENT issue ofThe Journalcontains the encouraging results of Youngner et al,<sup>1</sup>who found a willingness among physicians in a large university hospital to write a "do not resuscitate" (DNR) order for patients then residing in the medical intensive care unit. The authors found that 14% of the patients, otherwise requiring the more concentrated nursing attention of an intensive care unit, had received a DNR order. While it was reassuring that patients were given the level of care dictated by their medical condition despite their DNR status, the authors did raise the issue of overtreatment and proper allocation of limited medical resources. In an accompanying editorial, Veatch<sup>2</sup>both praised the Youngner et al study and also raised important ethical concerns over how the decision to write a DNR order was reached. The amount of actual participation by the patient in the decision not to undergo resuscitation
Index of Authors and Participants in Discussions
Journal: JNCI Journal of the National Cancer Institute (1952)

Journal Article Index of Authors and Participants in Discussions Get access JNCI: Journal of the National Cancer Institute, Volume 13, Issue 1, August 1952, Pages 269–270, https://doi.org/10.1093/jnci/13.1.269 Published: 01 August 1952
Twelve-month interim analysis of efficacy and safety of givosiran, an investigational RNAi therapeutic for acute hepatic porphyria, in the envision open label extension
Authors: Eliane Sardh, Manisha Balwani, David Rees, Penelope Stein, Ulrich Stözel, Paula Aguilera, D. Montgomery Bissell, Herbert Bonkovsky, Sioban Keel, Charles Parket, John Phillips, Samuel Silver, Jerzy Windyga, Delia D’Avola, Gayle Ross, Peter Stewart, Bruce Ritchie, Pauline Harper, Jiaan-Der Wang, Janneke Langendonk Langendonk, Aneta Ivanova, Yutaka Horie, Karl Anderson, Paolo Ventura, Maria Domenica Cappellini, Daphne Vassiliou, Susana Monroy-Santoyo, Petro Petrides, Tomohide Adachi, David Kuter, Sushama Scalera, Craig Penz, Gary Liu, John Ko, Amy Simon, Laurent Gouya
Journal: Journal of Hepatology (2020)
Lessons in Disinfection and Sterilization. An Elementary Course of Bacteriology, Together with a Scheme of Practical Experiments Illustrating the Subject-matter.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Book Reviews
Journal: Allergy (1985)

Book reviews in this article: Clark, T. J. H. &amp; Cochrane, G. M. (eds.); Bronchodilator therapy. Wilken‐Jensen, K. &amp; Gravesen, S. : Atlas of moulds in Europe causing respiratory allergy de Vries, R. R. P. &amp; van Rood, J. J. (eds.): Immunobiology of HLA class‐I and class‐II molecules. Dukor, P., Kallos, P., Schlumberger, H. D. &amp; West, G. B. (eds.(: Idiopathic, food‐induced and drug‐induced pseudo‐allergic reactions. Gerrard, J. M. : Prostaglandins and leukotrienes. Blood and vascular cell function.
THE BORDERLAND OF RHINOLOGY, NEUROLOGY AND OPHTHALMOLOGY
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Methyl Isocyanate: Reproductive and Developmental Toxicology Studies in Swiss Mice
Authors: B. A. Schwetz, B. Adkins, M. Harris, M. Moorman, R. Sloane
Journal: Environmental Health Perspectives (1987)

Studies were conducted in Swiss (CD-1) mice to evaluate the potential of inhaled vapors of methyl isocyanate (MIC) to affect reproduction and development. Inhaled MIC at concentrations of 0, 1, or 3 ppm, 6 hr per day during days 14 through 17 of gestation caused a significant increase in the number of dead fetuses at birth and caused a significant decrease in neonatal survival during lactation. In contrast, exposure of male and female mice to 1 or 3 ppm given 6 hr per day for 4 consecutive days had no effect on reproduction during mating trials conducted 1, 8, and 17 weeks after the exposure period. Similarly, there was no evidence of a dominant lethal effect in exposed male mice.
MicroRNA profiling of peripheral blood enriched for circulating tumor cells (CTCs) in testicular germ cell tumors (TGCTs).
Authors: Jozef Mardiak, Igor Jurisica, William Klement, Paulina Gronesova, Vera Miskovska, Jana Obertova, Jan Rajec, Zuzana Sycova-Mila, Vanda Usakova, Katarina Sevcikova, Michal Chovanec, Daniela Svetlovska, Peter Bujdak, Dana Jurkovicova, Stanislav Spanik, Dalibor Ondrus, Michal Mego
Journal: Journal of Clinical Oncology (2014)

e15530 Background: CTCs are prognostic in several tumor types and are easily accessible for repeat examination. TGCTs represent a model for the cure of cancer. We investigated microRNA expression profiling of peripheral blood (PB) enriched for CTCs in TGCTs aimed to identify miR associated with treatment resistance. Methods: This prospective study included 14 patients (pt) treated with first line (11 pt) or salvage (3 pt) chemotherapy. Peripheral mononuclear cells (PBMCs) were isolated from 10mL of peripheral blood on day 1 of first cycle of chemotherapy. Isolated PBMC were depleted of cells of hematopoietic origin (CD45+) using RossetteSep kit negative selection with anti-CD45 antibody. CD45-depleted PBMC represent compartment enriched for CTCs, as shown previously. MicroRNA (miR) was extracted from CD45- PBMCs and the expression profiles were obtained using Agilent Human microRNA Microarray v2.0 (Agilent Technologies). Results: Four patients had unfavorable response to chemotherapy (other than complete response or partial response with negative serum markers). We identified 38 miRs that were expressed at significantly different levels in patients with favorable (4 pt) vs. unfavorable (10 pt) response to chemotherapy, including hsa-mir-4516, hsa-mir-6087, hsa-mir-642a-3p, hsa-mir-197-5p, hsa-mir-3960, hsa-mir-4459, hsa-mir-3676-5p; hsa-mir-29a-3p, hsa-mir-301a-3p, hsa-mir-374b-5p. We have also identified 52 miRs that were expressed at significantly different levels in patients with good prognosis (8 pt) according to IGGCCG compared to poor prognosis patients (5 pt), including hsa-mir-4530, hsa-mir-197-5p, hsa-mir-4516, hsa-mir-6090, hsa-mir-4465, hsa-mir-6087, hsa-mir-642a-3p; hsa-mir-29a-3p, hsa-mir-23b-3p. Conclusions: Our data suggest that microRNA expression profiling of PB enriched for CTCs in TGCTs is feasible, and show great promise in identifying new therapeutic targets and gene expression signature associated with treatment resistance.
Abstract 11033: Association of Albuminuria With Cardiac Dysfunction in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) Echocardiographic Study of Latinos (Echo-SOL) Ancillary Study
Authors: David B Hanna, Shuo Xu, Michal L Melamed, Franklyn Gonzalez, Robert C Kaplan, Carlos J Rodriguez, Jorge R Kizer
Journal: Circulation (2015)

Introduction: Higher urinary albumin has been associated with cardiac dysfunction in the general population. The generalizability of these findings to Hispanics/Latinos, a group in which ethnic CVD disparities have been documented, is unknown. Methods: Echo-SOL is an ancillary study of the HCHS/SOL, a population-based study of Hispanics/Latinos across 4 US sites. Echo-SOL participants underwent standard echocardiography. Urine albumin-to-creatinine ratio (UACR) was used to assess albuminuria and categorized as normal and high normal (based on the midpoint of values below microalbuminuria), microalbuminuria (≥17 mg/g for men; ≥25 for women), and macroalbuminuria (≥250; ≥355). Outcomes included left ventricular (LV) hypertrophy (using standard sex-specific cutpoints for LV mass index), LV systolic dysfunction (EF&lt;50%), and any LV diastolic dysfunction. We assessed the association of UACR with cardiac dysfunction, adjusting for demographics (sex, age, Hispanic/Latino background) and cardiometabolic factors. Results: The study sample consisted of 1,525 participants (median age 54, female 65%, median BMI 29, diabetes 27%). Overall, 43% had normal UACR, 43% high normal UACR, 12% microalbuminuria, and 2% macroalbuminuria. The prevalence of LV hypertrophy was 13%, LV systolic dysfunction 3%, and diastolic dysfunction 59%. After adjustment, both micro- and macroalbuminuria were significantly associated with LV hypertrophy but not LV systolic dysfunction (Table). Increasing levels of albuminuria, even at high normal levels, were significantly associated with greater diastolic dysfunction. Conclusions: Higher UACR was associated with LV hypertrophy and diastolic dysfunction in the largest known population sample of US Hispanic/Latinos. These findings suggest that screening and detection of even high normal UACR could be of value to guide CVD prevention efforts among Hispanic Americans, who may represent an especially vulnerable population.
Expression of the DNA-Binding Factor TOX Promotes the Encephalitogenic Potential of Microbe-Induced Autoreactive CD8+ T Cells
Authors: Nicolas Page, Bogna Klimek, Mathias De Roo, Karin Steinbach, Hadrien Soldati, Sylvain Lemeille, Ingrid Wagner, Mario Kreutzfeldt, Giovanni Di Liberto, Ilena Vincenti, Thomas Lingner, Gabriela Salinas, Wolfgang Brück, Mikael Simons, Rabih Murr, Jonathan Kaye, Dietmar Zehn, Daniel D. Pinschewer, Doron Merkler
Journal: Immunity (2019)
Managing behavior problems in nursing homes
Authors: S. F. Jencks
Journal: JAMA (1991)

This issue of<i>JAMA</i>contains two disquieting articles on the use of neuroleptics and mechanical restraints in nursing homes. These articles have a special timeliness because of a growing movement, embodied in recent Health Care Financing Administration (HCFA)<sup>1</sup>regulations, to transform nursing homes into rehabilitative environments that promote individualized care and the highest practical levels of functioning and independence. A major objective of this movement is to limit the use of medication and mechanical restraints to purposes of medical treatment. For 15 years, evidence has been accumulating that nursing home residents receive more psychotropic drugs, especially neuroleptics, than is easily explained by good medical practice.<sup>2,3</sup>Garrard et al<sup>4</sup>confirm previous evidence that the prescribing of neuroleptic drugs is widespread (not news) and show that the reasons for such prescribing are poorly documented (a new finding). Specifically, only half of the neuroleptic therapy used in the study of
Comparative Evaluation of Genetic Toxicity Patterns of Carcinogens and Noncarcinogens: Strategies for Predictive Use of Short-Term Assays
Authors: Raymond W. Tennant, Judson W. Spalding, Stanley Stasiewicz, William D. Caspary, James M. Mason, Michael A. Resnick
Journal: Environmental Health Perspectives (1987)

The results of a recent comprehensive evaluation of the relationship between four measures of in vitro genetic toxicity and the capacity of the chemicals to induce neoplasia in rodents carry some important implications. The results showed that while the Salmonella mutagenesis assay detected only about half of the carcinogens as mutagens, the other three in vitro assays (mutagenesis in MOLY cells or induction of aberrations or SCEs in CHO cells) did not complement Salmonella since they failed to effectively discriminate between the carcinogens and noncarcinogens found negative in the Salmonella assay. The specificity of the Salmonella assay for this group of 73 chemicals was relatively high (only 4 of 29 noncarcinogens were positive). Therefore, we have begun to evaluate in vivo genetic toxicity assays for their ability to complement Salmonella in the identification of carcinogens.
American Journal of Surgery, New York
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
American Cancer Society Eleanor Roosevelt International Cancer Fellowships, 1978/1979
Journal: JNCI Journal of the National Cancer Institute (1978)

Journal Article American Cancer Society Eleanor Roosevelt International Cancer Fellowships, 1978/1979 Get access JNCI: Journal of the National Cancer Institute, Volume 61, Issue 1, July 1978, Page 269, https://doi.org/10.1093/jnci/61.1.269 Published: 01 July 1978
ACIDOSIS AND THE PRODUCTION OF EDEMA
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal