tbuckley/cabot-search huggingface dataset:
光疗祛痘:包含等级评估的缩减版科克伦系统综述
Authors: J. Barbaric, R. Abbott, P. Posadzki, M. Car, L.H. Gunn, A.M. Layton, A. Majeed, J. Car
Journal: British Journal of Dermatology (2018)

寻常痤疮是一种常见的皮肤问题,可导致黑头、白头以及红斑。痤疮通常会留下非常难治的痘印。痤疮可能导致严重的心理和社交问题,包括自尊心受挫、焦虑、沮丧以及情绪低落。许多光疗法已试验用于治疗寻常痤疮,但其效果和安全性尚不明确。光疗法使用具有不同性质(比如波长和强度)的光。虽然具体机理尚未完全弄清,但有三个因素至关重要:光、感光剂(即:吸收并随后通过光激化的分子)以及通过激化产生的氧化应激。大家认为,这种氧化应激有助于破坏致菌痤疮并防止毛孔堵塞。该研究综述了不同的光疗祛痘试验。研究人员发现,有关使用光疗祛痘的高质量证据尚且缺乏。有证据表明甲基氨基酮戊酸盐光动力疗法(红光)有效,证据质量尚可。此外,有证据表明氨基酮戊酸光动力疗法(蓝光)在作为标准疗法治疗中度到重度痤疮方面有效,但证据质量不高。通过该综述,更加有必要确定标准化结果测量指标(定义治疗是否成功的方法)、扩大更高质量的研究规模并且充分报告未来研究。
LAY INFLUENCES IN MEDICAL AFFAIRS.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Survival of Elderly Patients with Colon Cancer Treated with Chemotherapy
Journal: Annals of Internal Medicine (2002)

Summaries for Patients5 March 2002Survival of Elderly Patients with Colon Cancer Treated with ChemotherapySearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-136-5-200203050-00002 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Colon cancer is cancer of the large intestine. If colon cancer is found in its early stages, it can often be successfully treated with surgery. If colon cancer has spread outside of the colon to the lymph nodes (node-positive colon cancer), the addition of chemotherapy that includes the drug 5-fluorouracil (5-FU) helps patients survive longer. However, such treatment is less common in patients 65 years of age and older than it is among younger patients. Some think that doctors are reluctant to advise older patients to have chemotherapy ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Survival Associated with 5-Fluorouracil-Based Adjuvant Chemotherapy among Elderly Patients with Node-Positive Colon Cancer.” It is in the 5 March 2002 issue of Annals of Internal Medicine (volume 136, pages 349-357). The authors are V Sundararajan, N Mitra, JS Jacobson, VR Grann, DF Heitjan, and AI Neugut.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians–American Society of Internal Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoSurvival Associated with 5-Fluorouracil–Based Adjuvant Chemotherapy among Elderly Patients with Node-Positive Colon Cancer Vijaya Sundararajan , Nandita Mitra , Judith S. Jacobson , Victor R. Grann , Daniel F. Heitjan , and Alfred I. Neugut Metrics 5 March 2002Volume 136, Issue 5Page: I-19KeywordsChemotherapyColorectal cancerDrugsElderlyLarge intestineLymph nodesMedicarePatientsStatistical methodsSurgery ePublished: 5 March 2002 Issue Published: 5 March 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Liquid Air
Authors: Daniel C. Weaver
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PARIS
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Update: Influenza Activity— United States and Europe, 1993-94 Season
Journal: JAMA (1994)

In collaboration with the World Health Organization (WHO) international collaborating laboratories and with state and local health departments in the United States, CDC conducts surveillance to monitor influenza activity and to detect antigenic changes in the circulating strains of influenza viruses. Laboratory surveillance indicates the predominance of influenza type A so far this season. This report summarizes influenza activity in the United States and Europe from mid-September through mid-November 1993.
Hypercalcitoninemia, pheochromocytoma, and C-cell hyperplasia. A new variant of Sipple's syndrome
Authors: M. D. Ram
Journal: JAMA (1978)

IN 1961, Sipple<sup>1</sup>reported an increased incidence of carcinoma of the thyroid in patients with pheochromocytoma and noted that this association was 14 times greater than in the general population. However, it was apparently not appreciated by Sipple that the carcinoma was of the medullary type. In 1962, it was reported that parathyroid adenomas also occur with some degree of frequency in this syndrome. Williams<sup>2</sup>reviewed the pathologic characteristics of the thyroid carcinomas and found that they were all of the medullary variety. Since then, Sipple's syndrome has been recognized as a form of multiple endocrine adenopathy, and in the last few years, other features, eg, familial incidence, carcinoid syndrome, mucosal neuromas, marfanoid habitus, megacolon, and Cushing's syndrome, have all been reported. We report a new variant of Sipple's syndrome in which the patient had a pheochromocytoma, hypercalcitoninemia, and C-cell hyperplasia. We believe this to be the first
P154 Safety of tiotropium in pre-school children with symptomatic persistent asthma
Journal: Thorax (2016)

AbstractH Bisgaard has been a consultant for AstraZeneca, Boehringer Ingelheim and Chiesi; M Vandewalker has received research grants and personal fees from Boehringer Ingelheim; L Graham made no relevant disclosures;P Moroni-Zentgraf is an employee of Boehringer Ingelheim; M Engel is an employee of Boehringer Ingelheim; G El Azzi is an employee of Boehringer Ingelheim; SD Vulcu is an employee of Boehringer Ingelheim; H Finnigan is an employee of Boehringer Ingelheim; EJLE Vrijlandt has received personal fees from Boehringer Ingelheim
Hepatitis delta virus replication and liver cell proliferation in neoplastic and non-neoplastic liver tissue . Gastroenterology Division and 3Dept. of Pathology, University Hospital, Geneva, Switzerland; 1Dept. Biomedical Sciences and Human Oncology, University of Torino; and 2Institute of Morbid Anatomy, Mauriziano Hospital, Torino, Italy
Journal: Hepatology (1995)
Maternal Death
Authors: Joan Stephenson
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
IRREVERSIBLE SIDE EFFECTS OF PHENOTHIAZINES
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Canadian multicenter double-blind randomized controlled trial of ursodeoxycholic acid in primary biliary cirrhosis
Authors: E Heathcote
Journal: Hepatology (1994)

Ursodeoxycholic acid, a dihydroxyl bile acid normally present in human beings in minimal amounts, becomes incorporated into the bile salt pool when taken orally. In cholestasis, bile acids are retained in the liver and are hepatotoxic. Ursodeoxycholic acid is the least-known hepatotoxic bile acid, has choleretic properties and is reported to benefit patients with chronic cholestasis. In a nationwide Canadian controlled trial, 222 patients with primary biliary cirrhosis were treated with ursodeoxycholic acid (14 mg/kg/body wt/day) or placebo for 24 mo. Only patients with a diagnosis confirmed by liver biopsy and serum positive for antimitochondrial antibodies were enrolled; 88% were symptomatic on entry. The primary outcome measure was percent change in total serum bilirubin from baseline to final follow-up. Treated patients (111) and controls (111) were comparable with regard to age, gender, biochemical parameters and liver histological condition. Although treatment was not associated with any improvement in symptoms, ursodeoxycholic acid therapy caused the bilirubin to fall significantly within the first 3 mo of therapy (p<0.001). Significant falls in serum alkaline phosphatase, aminotransferases, cholesterol and IgM levels were also noted in the treated group. Improvement in some histological features was observed but there was no difference between the groups in the number of patients who reached the endpoints of death or liver transplantation. Ursodeoxycholic acid, given to patients with primary biliary cirrhosis, leads to an improvement in serum markers of cholestasis. A larger sample size is needed to determine whether ursodeoxycholic acid therapy has a beneficial effect on the survival of patients with primary biliary cirrhosis. (HEPATOLOGY 1994;19:1149–1156.)
Regional Deposition of Inhaled Fog Droplets: Preliminary Observations
Authors: Stephen M. Bowes, Beth L. Laube, Jonathan M. Links, Robert Frank
Journal: Environmental Health Perspectives (1989)

The regional deposition of a monodisperse 10-micron mass median aerodynamic diameter fog was studied in four healthy adult male nonsmokers. The fog was radiolabeled with technetium-99m sulfur colloid to enable detection by an Anger camera of deposited activity in the following regions of the respiratory tract: oropharynx, larynx, trachea, and intrapulmonary airways. Intrapulmonary deposition was further analyzed by computer with inner, intermediate, and outer zones, and within apical, intermediate and basal zones of the right lung. The radiolabeled aerosol was inhaled by mouth through a face-mask with the nasal airway occluded. Respiratory frequency, tidal volume, and jaw position were controlled and were commensurate with the oral component of oronasal breathing during moderate exercise. Deposition in the larynx, trachea, and intrapulmonary airways was a function of the scrubbing efficiency of the oropharynx, which differed substantially among subjects, and ranged from 72 to 99%. The density of the aerosol deposit in the larynx probably exceeded that of any of the subdivisions of the tracheobronchial tree and lung. Within the lung, deposition favored the inner zone (assumed to contain the larger airways) over the outer zone (assumed to be dominated by smaller airways and alveoli). Intrapulmonary aerosol distribution in an elderly subject with borderline evidence of airway obstruction differed from that observed in younger subjects. The possible consequences of altered lung elastic recoil, as may occur with aging, for regional dosimetry is discussed.
Fatalities Among Volunteer and Career Firefighters—United States, 1994-2004
Journal: JAMA (2006)

Approximately 800,000 firefighters in the United States are volunteer firefighters and 300,000 are career firefighters. Volunteer firefighters primarily serve communities with fewer than 25,000 inhabitants, whereas most career firefighters serve communities of more than 25,000 persons. To characterize fatalities among volunteer and career firefighters, CDC analyzed data from the U.S. Fire Administration (USFA). This report summarizes the results of that analysis and, to illustrate the most common types of volunteer and career firefighter fatalities, describes two cases investigated by the National Institute for Occupational Safety and Health (NIOSH) Firefighter Fatality Investigation and Prevention Program. Fifty-three percent (610 of 1,141) of U.S. firefighters who died while on duty during 1994-2004 were volunteers, and 32% (368) were career firefighters. The remaining 15% (163) of deaths were among other firefighters (e.g., wildland, paid on-call, and part-time paid firefighters). Among volunteer firefighters, sudden cardiac death (e.g., from myocardial infarction or arrhythmia) and motor vehicle (MV) crashes during emergency response were the leading causes of fatality. Among career firefighters, sudden cardiac death and asphyxiation were leading causes of death. Adoption and enforcement of existing fire-service recommendations regarding fitness standards, mandatory medical evaluations with appropriate work restrictions, and emergency vehicle response protocols are needed to prevent these fatalities among firefighters.
Assessment of hepatic iron overload in thalassemic patients by magnetic resonance spectroscopy
Authors: R Dixon
Journal: Hepatology (1994)

The transverse relaxation time of water protons is shortened by the presence of iron. This shortening depends on the amount and the environment of iron in the sample. We have developed a method for measuring short transverse relaxation time noninvasively by magnetic resonance spectroscopy. To evaluate magnetic resonance spectroscopy as a means of assessing hepatic iron content in patients with transfusional iron overload, we compared the results obtained with this method with those obtained by other means of assessing total body iron content. The correlation between the liver biopsy iron concentration and 1/transverse relaxation time was highly significant (r = 0.95, p < 0.004, n = 6) for iron loads up to 3% dry weight. The correlation between serum ferritin and 1/transverse relaxation time was also significant, but the correlation coefficient was much lower (r = 0.67, p < 0.002, n = 20). The correlation between 24-hr urinary iron excretion and 1/transverse relaxation time was not significant, nor was that between AST and 1/transverse relaxation time. We conclude that magnetic resonance spectroscopic determination of the transverse relaxation time of hepatic water is an accurate method of measuring liver iron content, especially when the iron content is below 3%. Because it is a noninvasive method that is associated with negligible side effects, it could provide clinicians with an excellent means of assessing the effectiveness of the various therapeutic strategies used in the management of patients with iron overload. (HEPATOLOGY 1994;19:904–910.)
Instructions for Authors
Journal: JAMA (1984)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Drug promotion in a family medicine training center
Authors: A. F. Shaughnessy
Journal: JAMA (1988)

<h3>To the Editor.—</h3> Advertising of pharmaceuticals is so commonplace that its potential impact on the practice of medicine often is overlooked. A family medicine residency training center was surveyed to determine the extent of drug promotion within this teaching environment. <h3>Study.—</h3> The family medicine center studied serves as a university-affiliatedtraining site for 39 family medicine residents and medical and pharmacy students. Patient-care areas consist of 24 examination rooms, five nursing stations, a waiting area, and four common hallways where prescription pads and prescribing information are kept. Access of medical service representatives to the center is limited to a "display room" that residents, students, and staff may visit to discuss the advertised product. Samples are kept in a locked cabinet. Any promotional material found in the center other than in these two areas is placed there by faculty or staff. Each patient-care area was surveyed for any type of promotional
Care of pregnant women infected with HIV
Authors: P. Wortley
Journal: JAMA (1994)

<h3>To the Editor.</h3> —Because no recognized guidelines specifically address prophylactic treatments such as zidovudine and primary<i>Pneumocystis carinii</i>pneumonia prophylaxis for pregnant women infected with the human immunodeficiency virus (HIV),<sup>1,2</sup>current physician prescribing practices for such women may vary widely. In this analysis, we reviewed medical records of a sample of pregnant women from the Adult and Adolescent Spectrum of HIV Disease Project (ASD), a large, multisite, observational study started in January 1990 in which medical records of HIV-infected persons receiving medical care are reviewed at regular intervals.<sup>3</sup>Among2050 women identified before November 1992, 367 (18%) had been pregnant during the previous year. Using information collected routinely in this project and additional information specifically abstracted for the pregnant women in this analysis (eg, exact dates of pregnancy and drug prescription), we examined physicians' prescription practices for 86 pregnant women with CD4<sup>+</sup>T-lymphocyte cell counts less than 0.50×10<sup>9</sup>
Trimethoprim-Sulfamethoxazole
Authors: Jan Koch-Weser, Robert H. Rubin, Morton N. Swartz
Journal: New England Journal of Medicine (1980)

Trimethoprim–sulfamethoxazole (TMP-SMX) is a fixed combination of two antimicrobial agents — a diaminopyrimidine (trimethoprim) and a sulfonamide (sulfamethoxazole) — purposely chosen to provide sequential and synergistic inhibition of bacterial folate metabolism. Although a parenteral formulation of this combination is currently under evaluation, TMP-SMX is generally available only for oral use. It is marketed in a fixed drug ratio of one part TMP to five parts SMX (single-strength tablets contain 80 mg of TMP and 400 mg of SMX, double-strength tablets contain 160 mg of TMP and 800 mg of SMX, and an oral suspension contains 40 mg of TMP and . . .