THE RELATION OF SPECIFIC IMMUNITY TO RECOVERY FROM PNEUMOCOCCUS PNEUMONIA TREATED WITH THE SULFONAMIDES
Authors: P. C.
Journal: Annals of Internal Medicine (1942)

Editorial1 March 1942THE RELATION OF SPECIFIC IMMUNITY TO RECOVERY FROM PNEUMOCOCCUS PNEUMONIA TREATED WITH THE SULFONAMIDESP. C.P. C.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-16-3-577 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe remarkably successful results obtained clinically in the treatment of pneumococcus pneumonia with the sulfonamide drugs have stimulated interest in the mechanism of their action, and in their influence on the development of immunity to this organism.Earlier studies by Whitby1and others of the effect of sulfapyridine on pneumococci in vitro showed that in concentrations such as can be obtained in the animal body, it exerts a bacteriostatic effect, inhibiting the growth of the organisms without actually destroying them. In higher concentrations an actual bactericidal action may be manifested. This action is not exerted immediately. In a freshly inoculated...1 WHITBY LE: Chemotherapy of pneumococcal and other infections with 2 (p-amino-benzenesulfonamido) pyridine, Lancet, 1938, i, 1210-1212. CrossrefGoogle Scholar2 MCINTOSHWHITBY JLE: The mode of action of drugs of the sulfonamide group, Lancet, 1939, i, 431-435. CrossrefGoogle Scholar3 SPRINGLOWELLFINLAND WCFCM: Studies on the action of sulfapyridine on pneumococci, Jr. Clin. Invest., 1940, xix, 163-177. CrossrefGoogle Scholar4 WOODLONG WBPH: Observations upon the experimental and clinical use of sulfapyridine. III. The mechanism of recovery from pneumococcal pneumonia in patients treated with sulfapyridine, ANN. INT. MED., 1939, xiii, 612-617. Google Scholar5 FINLANDSPRINGLOWELL MWCFC: Immunological studies on patients with pneumococcic pneumonia treated with sulfapyridine, Jr. Clin. Invest., 1940, xix, 179-198. CrossrefGoogle Scholar6 FINLAND M: Sulfadiazine: therapeutic evaluation and toxic effects on 446 patients, Jr. Am. Med. Assoc., 1941, cxvi, 2641-2647. CrossrefGoogle Scholar7 KNEELANDMULLIKEN YB: Antibody formation in cases of lobar pneumonia treated with sulfapyridine, Jr. Clin. Invest., 1940, xix, 307-312. CrossrefGoogle Scholar8 FOXROSIWINTERS WWRWL: The Sabin agglutination test and the polysaccharide skin test (Francis) as indices of recovery in pneumonia, Am. Jr. Med. Sci., 1940, cc, 649-655. CrossrefGoogle Scholar9 HAVILAND JW: Type 1 pneumococcal pneumonia. Clinico-immunological studies with special reference to the rationale of combined serum and drug therapy, Bull. Johns Hopkins Hosp., 1941, lxviii, 32-50. Google Scholar10 CURNENMCLEOD ECCM: The effect of sulfapyridine upon the development of immunity to pneumococcus in rabbits, Jr. Exper. Med., 1942, lxxv, 77-92. CrossrefGoogle Scholar11 PLUMMER N: Chemotherapy versus combined chemotherapy and serum, Jr. Am. Med. Assoc., 1941, cxvi, 2366-2371. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1942Volume 16, Issue 3Page: 577-580KeywordsAttentionDrugsImmunityPneumococcusPneumoniaSulfonamide ePublished: 1 December 2008 Issue Published: 1 March 1942 PDF downloadLoading ...