tbuckley/cabot-search huggingface dataset:
New Test for Milk.
Journal: JAMA (1887)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
New dimensions to dementia.
Journal: Environmental Health Perspectives (1997)

Xenohormones, endogenous hormones CYP450-dependent 17p-oxidoreductase aromatase Total bioavailable estradiol E2 ' El CYP450-dependent hydroxylases 2-OHEI, 2-OHE2 16a-OHE1, 4-OHEl 2-MeOHE1 4-OHE2 (E2 antagonists) (E2
Dermatologie Formulary
Journal: JAMA (1953)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Utopia
Authors: Thomas More
Journal: Annals of Internal Medicine (1997)

Brief Communications1 December 1997UtopiaThomas MoreThomas MoreSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-127-11-199712010-00005 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail He is a poor physician indeed who cannot cure a patient without producing another disease.Thomas MoreUtopiaSubmitted by:Mark R. Tonelli, MDUniversity of Washington School of Medicine; Seattle, WA 98195 Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDo cryptocurrencies really have (no) intrinsic value?Needed yesterday: a world that never wasGulliver and the Gentle Reader1[Dream] Images of Earth in Quarantine – Some Photographs in Times of Crisis without HumansRethinking Utopia: the search for ‘topias’ in the Paris catacombsOld Age and Euthanasia in Anthony Trollope’s The Fixed PeriodApprehending Global Civilisation in The Magic Lamp : Giving the World a New LiteratureEvoking the Female ‘Asexual’: Narrating the Silenced SelfDomesticating the future?: Citizen’s income discussion in EstoniaHaunted by the Holocaust: Hogan’s Heroes, The Producers, Fiddler on the RoofNotes on some possible hierarchies within anthropology’s anarchism(s)A short note on Martin Luther’s idea of business ethicsNarrativas de percursos e percursos narrados na superquadra modelo e na Vila do Boa: utopias e distopias em BrasíliaAnticipations: on the state of the planning imaginationThe discourse of counter-monuments: semiotics of material commemoration in contemporary urban spacesThe “Dying Role”: Its Time Had ComeIntroduction to the SymposiumMinimal Justice and Regime Change in Brian Orend's Political Ethics“A Parthenon on the Banks of the Clyde: Antiquity and Equality in The Revolt of the BeesUtopia’s Bubbles: Pneumatic Architecture of the 1960s and 1970s as a Vehicle for Urban ExhibitionismGlobal Forms: Allegory, Collage, and Virginia Woolf’s American UtopiaLe care, la migration et l’ordre de genreKhōra: An Inquiry Into Polytopian Philosophy and Cosmopolitan GovernanceCurious Prose and the History of English Interest in the AmericasStadsvernieuwing en utopie in Brussel : van ideaal naar realiseerbaar ?BibliographieS.E.K. Mqhayi: forerunner to democratic South AfricaCalvin on SuicideConcepts of Mental Retardation in Pakistan: Toward Cross-cultural and Historical PerspectivesBibliografiaAmare utopie 1 December 1997Volume 127, Issue 11Page: 980 Issue Published: 1 December 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Abstract A12: YAP-dependent induction of amphiregulin identifies a non-cell-autonomous component of the Hippo pathway
Authors: Jianmin Zhang, Jun-Yuan Ji, Min Yu, Michael Overholtzer, Gromoslaw A. Smolen, Joan S. Brugge, Nicholas J. Dyson, Daniel A. Haber
Journal: Cancer Research (2009)

Abstract The Hippo signaling pathway was initially identified in Drosophila and components in this pathway are highly conserved in mammals. We and others have recently shown that the Hippo pathway regulates cellular proliferation and survival, thus exerting profound effects on normal cell fate and tumorigenesis. The pivotal effector of this pathway is YAP, a transcriptional co-activator amplified in mouse and human cancers, where it promotes epithelial to mesenchymal transition (EMT) and malignant transformation. To date, studies of YAP target genes have focused on cellautonomous mediators. Here, we show that YAP-expressing MCF10A breast epithelial cells secrete growth factors that enhance the proliferation of neighboring untransfected cells, implicating a non-cell autonomous mechanism. Using cytokine and growth factor array analysis, we identified the epidermal growth factor receptor (EGFR) ligand, amphiregulin (AREG), as a transcriptional target of YAP, whose induction contributes to YAP-mediated cell proliferation and migration. Knockdown of AREG or addition of an EGFR kinase inhibitor abrogates the proliferative effects of YAP expression. Suppression of the negative YAP regulators LATS1/2 is sufficient to induce AREG expression, consistent with a physiological regulation of AREG by the Hippo pathway. Furthermore, genetic interactions between the Drosophila YAP orthologue Yki and Egfr signaling components support the link between these two highly conserved signaling pathways. In conclusion, YAP-dependent secretion of AREG implicates activation of EGFR signaling as an important non-cell autonomous effector of the Hippo pathway, with relevance for the regulation of both physiological and malignant cell proliferation. Citation Information: Cancer Res 2009;69(23 Suppl):A12.
The Cancer Process.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Which Transplant Technique Will Let Cystic Fibrosis Patients Breathe Easier?
Authors: Marsha F. Goldsmith
Journal: JAMA (1990)

NEW LUNGS for old as a means of prolonging the lives of persons with cystic fibrosis is a prospect that has inspired researchers in the past few years. At two recent meetings, developments in this specialized area of organ transplantation were reported. In Toronto, Ontario, participants in the annual meeting of the American Association for Thoracic Surgery heard from Marc R. deLeval, MD, who is the group's 24th Evarts A. Graham Memorial Traveling Fellow. DeLeval has been working in the Lung Transplant Research Unit at Papworth Hospital, Cambridge, England. The program there receives worldwide recognition. He presented a report on heart-lung transplantation performed there during the past 4 years on 32 patients who were severely impaired—near death from advanced respiratory failure—because of cystic fibrosis. He then compared the results in this group with results in 61 patients without the disease who received heart-lung transplants at Papworth Hospital during the same
Irradiation to the head and neck area and thyroid cancer
Authors: O. H. Beahrs
Journal: JAMA (1980)

THIS COMMENTARY is being written in response to the article by Royce et al, entitled "Value of Postirradiation Screening for Thyroid Nodules" (<i>JAMA</i>242:2675-2678, 1979). The communication comes from principals involved in a workshop on this subject sponsored by the National Cancer Institute, which resulted in the recommendations now brought into question by that article. One conclusion in the article is that irradiation of the head and neck may not be a causative factor in the development of thyroid cancer. This point of view was emphasized in the accompanying editorial by Robert T. Utiger, MD, in the same issue, entitled "Is External Irradiation a Risk Factor for Thyroid Disease and Thyroid Carcinoma?" (242:2702, 1979). It may create great concern among those patients who have had surgery for a thyroid nodule, possibly discovered as a result of the publicity on this subject during the last five years, and it may deter
Platelet monoamine oxidase values and genetic heterogeneity in schizophrenia research
Authors: M. Baron
Journal: JAMA (1981)

Platelet monoamine oxidase (MAO) activity is significantly reduced in chronic schizophrenics with family history of schizophrenia. The degree of reduction is related to the extent of genetic load. Schizophrenics with no affected relatives do not differ from control subjects. These findings are consistent with the hypothesis of genetic heterogeneity in schizophrenia. Discrepancies among previously reported data sets can thus be explained by overrepresentation of nongenetic phenocopies with normal MAO levels. The implications for biologic and genetic research in schizophrenia are discussed. (<i>JAMA</i>1981;246:1418-1421)
Travel Notes.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Vesiculobullous Skin Disease With Prominent Immunologic Feature
Authors: Larry E. Millikan
Journal: JAMA (1987)

WISE et al<sup>1</sup>first explored the realm of cutaneous immunofluorescence in 1962. After these initial steps, the landmark work of Beutner and Jordon<sup>2</sup>in the early '60s rapidly moved forward the diagnostic utility of cutaneous immunofluorescence and advanced our knowledge of the various vesiculobullous skin diseases, in which immunoreactants are demonstrated and thought to play a significant role. Even more sophisticated techniques have been developed that now provide remarkable insight into the anatomy of the dermal-epidermal structures and their interface and also provide insight into pathogenesis of these diseases and therapeutic potential for them. Since the last review of this situation in 1982, many advances have occurred in our understanding of the dermal-epidermal interface and pathophysiology of the mechanobullous or vesiculobullous diseases. This section updates our understanding of diseases previously covered (pemphigus, pemphigoid, dermatitis herpetiformis, chronic bullous dermatosis of childhood, and herpes gestationis) and adds an overview of
EMBR-27. NEOPLASTIC AND IMMUNE SINGLE CELL TRANSCRIPTOMICS DEFINE SUBGROUP-SPECIFIC INTRA-TUMORAL HETEROGENEITY OF CHILDHOOD MEDULLOBLASTOMA
Authors: Andrew Donson, Kent Riemondy, Sujatha Venkataraman, Nicholas Willard, Anandani Nellan, Bridget Sanford, Andrea Griesinger, Vladimir Amani, Siddhartha Mitra, Todd Hankinson, Michael Handler, Martin Sill, Jennifer Ocasio, Seth Weir, Daniel Malawsky, Timothy Gershon, Alexandra Garancher, Robert Wechsler-Reya, Jay Hesselberg, Nicholas Foreman, Rajeev Vibhakar
Journal: Neuro-Oncology (2021)

Abstract Medulloblastoma (MB) is a heterogeneous disease in which neoplastic cells and associated immune cells contribute to disease progression. To better understand cellular heterogeneity in MB we used single-cell RNA sequencing, immunohistochemistry and deconvolution of transcriptomic data to profile neoplastic and immune populations in childhood MB samples and MB genetically engineered mouse models (GEMM). Neoplastic cells clustered primarily according to individual sample of origin which is in part due to the effect of chromosomal copy number gains and losses. Harmony alignment of single cell transcriptomic data revealed novel MB subgroup/subtype-associated subpopulations that recapitulate neurodevelopmental processes and are associated with clinical outcomes. This includes photoreceptor-like cells and glutamatergic lineage unipolar brush cells in both GP3 and GP4 subgroups of MB, and a SHH subgroup nodule-associated neuronally-differentiated cell subpopulation. We definitively chart the spectrum of MB immune cell infiltrates, which reveals unexpected degree of myeloid cell diversity. Myeloid subpopulations include subgroup/subtype-associated developmentally-related neuron-pruning as well as antigen presenting myeloid cells. Human MB cellular diversity is recapitulated in subgroup-specific MB GEMM, supporting the fidelity of these models. These findings provide a clearer understanding of both the neoplastic and immune cell heterogeneity in MB and how these impact subgroup/subtype classification and clinical outcome.
From the NIH
Journal: JAMA (1978)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
WATER
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cephalosporin-associated pseudomembranous colitis
Authors: J. F. Tures
Journal: JAMA (1976)

Diarrhea and pseudomembranous colitis appeared in a patient receiving antibiotic therapy with cephalosporin derivatives only. There was a prompt remission following treatment with cholestyramine resin. (<i>JAMA</i>236:948-949, 1976)
A CASE OF CONGENITAL OBSTRUCTION OF THE POSTERIOR URETHRA
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sixty-Eighth Annual Meeting of the American Association for Cancer Research
Journal: JNCI Journal of the National Cancer Institute (1976)

Sixty-Eighth Annual Meeting of the American Association for Cancer Research Get access JNCI: Journal of the National Cancer Institute, Volume 57, Issue 6, December 1976, Page 1429, https://doi.org/10.1093/jnci/57.6.1429 Published: 01 December 1976
OP0211 Reprogramming of Metabolic Pathways Inhibits TLR2-Induced Inflammation in RA
Authors: T. Mcgarry, M. Biniecka, D. Veale, U. Fearon
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Recent studies have emphasized a tight link between the metabolic state and phenotype of immune/inflammatory cells. Metabolic turnover of the inflamed synovium may induce a cellular switch in energy production, characterised by a glycolytic flux, suppression of mitochondrial function and potentiation of inflammation. The role of Toll-like receptors (TLRs) in immune responses is well documented, however emerging evidence suggests they also play a role in metabolism. <h3>Objectives</h3> In this study, we examine mitochondrial function, cellular metabolism and synovial inflammation in response to TLR2 activation. <h3>Methods</h3> RA synovial explant cultures and RA synovial fibroblasts (RASFC) were cultured with TLR2-ligand Pam3CSK4 (1μg/ml). Mitochondria DNA (mtDNA) mutations were assessed using a Random Mutation Capture assay and reactive oxygen species (ROS), mitochondrial membrane potential (MMP) and ATP levels were quantified using fluorescent probes. Mitochondrial and glucose metabolism gene arrays were quantified by RT-PCR and the mitochondrial ultrastructure assessed by transmission electron microscopy (TEM). Surrogate markers of glycolysis PKM2, GLUT1, ATP5B and GAPDH were quantified in RA/OA synovium by immunohistochemistry. PKM2 was also assessed by western blotting and immunofluorescence. Finally, we examined the effect of glycolytic inhibitor 3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one (3PO) (20μM) on TLR2–induced cytokine production, invasion/migration and signalling components NFκBp65, Notch-1IC and p-STAT3. <h3>Results</h3> Pam3CSK4 significantly induced mtDNA mutation frequency, ROS, and inhibited the MMP. In parallel, Pam3CSK4 differentially regulated key mitochondrial genes SOD2, BNIP3 and BBC3 (all p&lt;0.05) and markedly altered the ultrastructure of mitochondria. Consistent with this, we demonstrated altered metabolic activity in RASFC, with induced PKM2 nuclear translocation, increased ATP levels and differential regulation of metabolic genes FBP1/2, PGAM2 and ACo2 (all p&lt;0.05), resulting in metabolic shift in favour of glycolysis. This change in metabolic activity was mirrored <i>in-vivo</i> where expression of PKM2, GLUT1 and ATP5B were significantly higher in RA synovium compared to OA (p&lt;0.05). Finally, reprogramming of metabolism using 3PO significantly inhibited TLR2-induced cytokine production, cell migration/invasion and transcriptional regulation of NFκBp65 and p-STAT3. <h3>Conclusions</h3> Reprogramming of metabolic activity in RA resulted in resolution of inflammation. These results show close interactions between innate immunity, metabolism and inflammation, further elucidation of these interactions may provide new insights to new therapeutic approaches in RA. <h3>Disclosure of Interest</h3> None declared