tbuckley/cabot-search huggingface dataset:
Amer J Obstetrics &amp; Gynecology, St. Louis
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE MEETING AT NEWPORT.
Journal: JAMA (1889)

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From J<i>AMA</i>’s Daily News Site
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pulmonary and Generalized Lysosomal Storage Induced by Amphiphilic Drugs
Authors: Zdenek Hruban
Journal: Environmental Health Perspectives (1984)

Administration of amphiphilic drugs to experimental animals causes formation of myelinoid bodies in many cell types, accumulation of foamy macrophages in pulmonary alveoli and pulmonary alveolar proteinosis. These changes are the result of an interaction between the drugs and phospholipids which leads to an alteration in physicochemical properties of the phospholipids. Impairment of the digestion of altered pulmonary secretions in phagosomes of macrophages results in accumulation of foam cells in pulmonary alveoli. Impairment of the metabolism of altered phospholipids removed by autophagy induces an accumulation of myelinoid bodies. The administration of amphiphilic compounds thus causes pulmonary intra-alveolar histiocytosis which is a part of a drug-induced lysosomal storage or generalized lipidosis. The accumulation of drug-lipid complexes in myelinoid bodies and in pulmonary foam cells may lead to alteration of cellular functioning and to clinical disease. Currently over 50 amphiphilic drugs are known. Unique pharmacological properties necessitate clinical use of some of these drugs. The occurrence and severity of potential clinical side effects depend on the nature of each drug, dosage and duration of treatment, simultaneous administration of other drugs and foods, individual metabolic pattern of the patient and other factors. Further studies on factors preventing and potentiating adverse effects of amphiphilic drugs are indicated.
Programmed "trendscription." A new approach to electrocardiographic monitoring
Authors: B. Lown
Journal: JAMA (1975)

A new approach to monitoring of episodic but frequently recurring arrhythmias has been developed, consisting of condensation of electrocardiographic information on a special drum recorder, a programmer that permits selection of intervals and durations for monitoring, and a telemetry unit for transmission of the electrocardiographic signal. We used this system to manage three selected cases. (<i>JAMA</i>232:39-43, 1975)
Immunologic aspects of granulomatous and interstitial lung diseases
Authors: J. N. Fink
Journal: JAMA (1987)

ASTHMA that is mediated by IgE— mast-cell mechanisms is the most common immunologic disease. However, other inflammatory lung diseases are increasingly being recognized as having an immune basis and their pathogenetic mechanisms are beginning to be understood. The granulomatous and interstitial lung diseases are an important part of this group. <h3>HYPERSENSITIVITY PNEUMONITIS</h3> Hypersensitivity pneumonitis, or extrinsic allergic alveolitis, is an immunologic inflammatory reaction involving the lung interstitium, terminal bronchioles, and alveoli and is due to hypersensitivity to antigenic organic dusts often encountered in occupations or hobbies.<sup>1</sup>Some of the more common antigens causing this reaction are listed in Table 13-1. <h3>Prevalence and Etiology</h3> The prevalence of the disease is unknown. Farmer's lung, pigeon breeder's disease, and ventilation pneumonitis are most frequently encountered in the United States. About 8% of dairy farmers have serum precipitins to thermophilic organisms and about 4% have farmer's lung. About 6% to 15% of persons
Polymerase chain reaction monitoring reduces the incidence of cytomegalovirus disease and the duration and side effects of antiviral therapy after bone marrow transplantation
Authors: H Einsele, G Ehninger, H Hebart, KM Wittkowski, U Schuler, G Jahn, P Mackes, M Herter, T Klingebiel, J Loffler
Journal: Blood (1995)
The Pulse.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Priapism following splenectomy in an unstable hemoglobin: Hemoglobin Olmsted β141 (H19) Leu→Arg
Authors: Isabelle Thuret, Josiane Bardakdjian, Catherine Badens, Henri Wajcman, Frederic Galacteros, Danielle Vanuxem, Henri Perrimond, Francis Giraud, Danielle Lena‐Russo
Journal: American Journal of Hematology (1996)

We report a case of severe priapism occurring in a patient with an unstable hemoglobin, Hb Olmsted (β141 Leu→Arg). This is a rare hemoglobin variant, which until now has been reported only once. The clinical course of the 12-year-old boy was characterized by severe hemolytic anemia leading to splenectomy and cholecystectomy at the age of 3.5 years. The priapism occurred 8 years after splenectomy, during a hemolytic febrile episode and required aspiration of the corpora cavernosa. This report raises the question of the benefit of splenectomy in patients suffering from a chronic hemolytic anemia such as that due to an unstable hemoglobin. This treatment lowers the frequency and the severity of acute hemolytic attacks, but several cases of vascular complications have been reported after splenectomy. © 1996 Wiley-Liss, Inc.
HOW THE FRENCH REGARD SURGICAL CARELESSNESS.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Efficacy of panitumumab and cetuximab in patients with chemotherapy-refractory wild-type KRAS exon 2 metastatic colorectal cancer (mCRC): Retrospective analysis of data from nationwide drug-reimbursement-access program
Authors: M. Swierkowski, A. Ptak-Chmielewska, A. Sliwczynski, T. Czeleko, Z. Teter, C. Szczylik
Journal: Annals of Oncology (2017)
HapMap Scanning of Novel Human Minor Histocompatibility Antigens
Authors: Yasuhito Nannya, Michi Kamei, Hiroki Torikai, Takakazu Kawase, Kenjiro Taura, Yoshihiro Inamoto, Taro Takahashi, Makoto Yazaki, Satoko Morishima, Koichi Miyamura, Tetsuya Ito, Yoshihisa Kodera, Yasuo Morishima, Toshitada Takahashi, Kiyotaka Kuzushima, Seishi Ogawa, Yoshiki Akatsuka
Journal: Blood (2008)
BICYCLING—PRO AND CON.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prothrombin Deficiency
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AB0055 Adalimumab elicits a restricted anti-idiotypic antibody response in autoimmune patients resulting in functional neutralization
Authors: P. van Schouwenburg, L.A. van de Stadt, R. de Jong, E. van Buren, S. Kruithof, E. de Groot, M. Hart, M. van Ham, T. Rispens, L. Aarden, G. Wolbink, D. Wouters
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Worldwide millions of patients are treated with monoclonal antibodies. These biological therapeutics can be immunogenic, resulting in antibody formation which lead to loss of response. Fully human biologics such as the anti-TNFα antibody adalimumab are considered to be weakly immunogenic, but we found that the majority of Rheumatoid Arthritis patients develop anti-drug antibodies (ADA) within 28 weeks of treatment. <h3>Objectives</h3> Here we unraveled the mechanism by which ADA lead to loss of response by investigating the full specificity of the repertoire of anti-adalimumab antibodies. <h3>Methods</h3> The specificity of the repertoire of anti-adalimumab antibodies in a cohort of 50 ADA-positive RA patients was elucidated. In inhibition experiments using TNFa and patient derived anti-adalimumab monoclonal antibodies that were recombinantly generated after isolation of adalimumab-specific B cells. <h3>Results</h3> The antibody response against adalimumab is highly restricted: Fab fragments of a single, monoclonal antibody specific for the idiotype of adalimumab inhibited 98.65% (25th-75th percentiles: 98.25- 99.90) of the total anti-adalimumab reactivity in sera of 50 different ADA-positive RA patients. Furthermore, we found that the anti-adalimumab response is confined to the TNFα binding region of adalimumab, thereby neutralizing its therapeutic efficacy. In line with this restricted specificity, we observed small immune complexes in the circulation of ADA-forming patients. <h3>Conclusions</h3> The humoral immune response against adalimumab is highly restricted and limited to the idiotype of the therapeutic antibody. All antibodies result in functional neutralization of the drug, thereby providing a mechanism in which ADA formation leads to clinical non-response. <h3>Disclosure of Interest</h3> None Declared
Serum Homocysteine levels are independently associated with mortality in Primary and Secondary Prevention patients derived from a high-risk clinic population.
Authors: Monica Acevedo, Gregory L. Pearce, Dennis L. Sprecher
Journal: Circulation (2001)

0015 Background: Elevated total homocysteine levels (tHCY) have been implicated as an independent risk factor for mortality in patients with known and no known CAD. Few data are available that compare tHCY as a predictor of mortality in both groups. Objectives: In an ongoing, high-risk cardiovascular Prevention Clinic we sought to determine whether tHCY showed evidence of short-term mortality independently of traditional risk factors in primary and secondary prevention patients. Methods: Short term mortality (mean follow-up 26 ± 15 months) was assessed in 2441 clinic patients (1103 primary and 1338 secondary prevention). Cox models were used to assess the unadjusted relationships between tHCY (quartiles: &lt; 9.4, 9.5-11.7, 11.8-14.7, &gt;14.7 μmol/L) and survival time with hazard ratios (HR) used to estimate mortality risk. Framingham global risk scores were calculated for each patient in order to adjust for traditional risk factors (age, gender, LDL-C, HDL-C, blood pressure, diabetes and smoking). Results: The mean age of the overall group was 56 ± 12 years, 34% were women and 62 patients died during the follow-up (18 for primary and 44 for secondary prevention). Serum tHCY quartile showed a relationship to mortality for primary and secondary prevention patients (HR 3.02 and 1.69 respectively) with and without adjustment for traditional risk factors and creatinine ( Table). Conclusions: Serum homocysteine levels are independently associated with mortality in primary and secondary Prevention patients derived from the same high-risk clinic population. Table 1.
Transmission of Infection by Endoscopy
Authors: Stanley B. Benjamin
Journal: Annals of Internal Medicine (1993)

Letters1 September 1993Transmission of Infection by EndoscopyStanley B. Benjamin, MD and John H. Bond, MDStanley B. Benjamin, MDSearch for more papers by this author and John H. Bond, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-5-199309010-00034 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In their recent review, Spach and associates [1] imply that infection risk is appreciable and that published reports probably represent a minority of all infections transmitted by endoscopy. The American Society for Gastrointestinal Endoscopy (ASGE) has been aware of the potential for endoscopic transmission of infection since the advent of fiberoptic flexible endoscopy, when more complicated instruments replaced rigid endoscopes. The ASGE, with other societies concerned with endoscopy, developed recommendations for the appropriate handling and care of endoscopes [2]. We are involved with the Food and Drug Administration and the Centers for Disease Control and Prevention in ...References1. Spach DH, Silverstein FE, Stamm WE. Transmission of infection by gastrointestinal endoscopy and bronchoscopy. Ann Intern Med. 1993; 118:117-28. Google Scholar2. Infection control during gastrointestinal endoscopy. Guidelines for clinical application, ASGE publication #1018. Gastrointest Endosc. 1988; 34:37S-40S. Google Scholar3. Hanson PJ, Gor D, Jeffries DJ, Collins JV. Elimination of high titre HIV from fiberoptic endoscopes. Gut. 1990; 31:657-60. Google Scholar4. Silverstein FE. Design considerations of a solution to endoscope contamination: the sheathed endoscope (Abstract). Gastrointest Endosc. 1992; 38:277. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByNatural bioburden levels detected on rigid lumened medical devices before and after cleaning 1 September 1993Volume 119, Issue 5Page: 440-441KeywordsAIDSDisclosureDisinfectionEndoscopyFood and Drug AdministrationGastrointestinal infectionsHIVHepatitis BHepatitis B virusRisk management Issue Published: 1 September 1993 CopyrightCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Risk factors for development of toxic shock syndrome. Association with a tampon brand
Authors: W. F. Schlech
Journal: JAMA (1982)

In September 1980, we interviewed by telephone 50 patients with menstrually associated toxic shock syndrome (TSS) who had onset of illness in July or August 1980. These women were asked to provide information about the type of menstrual sanitary products used during the menstrual period associated with their illness. We also interviewed 150 age-matched control subjects, who were asked the same questions for the menstrual period that occurred in the same month as the illness of the matched case. All 50 cases, but only 125 of 150 controls, used tampons. Among women using tampons, cases were more likely to have used Rely<sup>®</sup>brand tampons when compared with controls. No differences were found between cases and controls in the absorbency of tampon products used. No other factors studied through analysis of a follow-up questionnaire mailed five months after the first study were found to be significantly associated with the development of menstrually associated TSS. (<i>JAMA</i>1982;248:835-839)
Editor's Choice
Journal: British Journal of Dermatology (2019)

Topical bakuchiol for facial photoageingBakuchiol is a plant-derived phytochemical that is known to have retinoid-like eff ects in vitro.Dhaliwal and colleagues report a randomized trial in which 44 healthy participants with a mean age of 47 years applied bakuchiol 0.5% cream or retinol 0.5% cream for 12 weeks.Bakuchiol and retinol both signifi cantly decreased wrinkle surface area and hyperpigmentation, with no statistical diff erence between the compounds.Th e retinol users reported more facial skin scaling and stinging.Th e authors concluded that bakuchiol is comparable with retinol in its ability to improve photoageing and is better tolerated than retinol.
Chirurgie de la Tête et du Cou.
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal