Vitamin K to Correct Overanticoagulation
Authors: Vittorio Pengo
Journal: Annals of Internal Medicine (2009)

Letters15 September 2009Vitamin K to Correct OveranticoagulationVittorio Pengo, MD, Gentian Denas, MD, and Seena Padayattil Jose, MDVittorio Pengo, MDFrom Padua University Hospital, 35122 Padua, Italy.Search for more papers by this author, Gentian Denas, MDFrom Padua University Hospital, 35122 Padua, Italy.Search for more papers by this author, and Seena Padayattil Jose, MDFrom Padua University Hospital, 35122 Padua, Italy.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-151-6-200909150-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We read with interest the study by Crowther and colleagues (1). On the one hand, we appreciated the attempt to create some order in the management of patients who have received excessive anticoagulation, but on the other hand, we are concerned because the authors' conclusions suggest that changing the treatment policy used in many thrombosis centers in Italy is needed. Since the publication of our first work in the field (2), we usually give oral vitamin K to patients without bleeding events whose INR is greater than 5.0. In a recent retrospective study (3), we reported 1043 ...References1. Crowther MA, Ageno W, Garcia D, Wang L, Witt DM, Clark NP, et al. Oral vitamin K versus placebo to correct excessive anticoagulation in patients receiving warfarin: a randomized trial. Ann Intern Med. 2009;150:293-300. [PMID: 19258557] LinkGoogle Scholar2. Pengo V, Banzato A, Garelli E, Zasso A, Biasiolo A. Reversal of excessive effect of regular anticoagulation: low oral dose of phytonadione (vitamin K1) compared with warfarin discontinuation. Blood Coagul Fibrinolysis. 1993;4:739-41. [PMID: 8292723] CrossrefMedlineGoogle Scholar3. Denas G, Marzot F, Offelli P, Stendardo A, Cucchini U, Russo R, et al. Effectiveness and safety of a management protocol to correct over-anticoagulation with oral vitamin K: a retrospective study of 1,043 cases. J Thromb Thrombolysis. 2009;27:340-7. [PMID: 18338109] CrossrefMedlineGoogle Scholar4. Denas G, Cucchini U, Iliceto S, Pengo V. An oral vitamin K protocol to reverse over-anticoagulation in patients presenting with an international normalised ratio above 10.0 [Letter]. Thromb Haemost. 2009;101:410-1. [PMID: 19190831] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Vittorio Pengo, MD; Gentian Denas, MD; Seena Padayattil Jose, MDAffiliations: From Padua University Hospital, 35122 Padua, Italy.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoOral Vitamin K Versus Placebo to Correct Excessive Anticoagulation in Patients Receiving Warfarin Mark A. Crowther , Walter Ageno , David Garcia , Luqi Wang , Dan M. Witt , Nathan P. Clark , Mark D. Blostein , Susan R. Kahn , Sara K. Vesely , Sam Schulman , Michael J. Kovacs , Marc A. Rodger , Phillip Wells , David Anderson , Jeffery Ginsberg , Rita Selby , Sergio Siragusa , Mauro Silingardi , Mary Beth Dowd , and Clive Kearon Vitamin K to Correct Overanticoagulation Robert C. Pendleton and Sara Vazquez Vitamin K to Correct Overanticoagulation Ayad Jindeel Vitamin K to Correct Overanticoagulation P. Dileep Kumar Vitamin K to Correct Overanticoagulation Mark A. Crowther and David Garcia Vitamin K to Correct Overanticoagulation Mark W. Swaim and B. Gail Macik Metrics Cited byShort-term warfarin reversal for elective surgery - using low-dose intravenous vitamin K: safe, reliable and convenient* 15 September 2009Volume 151, Issue 6Page: 433KeywordsConflicts of interestDrugsHemorrhageInternational normalized ratioRetrospective studiesThrombosisVitamin K ePublished: 15 September 2009 Issue Published: 15 September 2009 Copyright & PermissionsCopyright © 2009 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...