tbuckley/cabot-search huggingface dataset:
Abstract 17570: Therapeutic Impact of Autophagy-inducing Peptide on Pressure Overload-induced Heart Failure
Authors: Akihiro Shirakabe, Yoshiyuki Ikeda, Peiyong Zai, Toshiro Saito, Junichi Sadoshima
Journal: Circulation (2015)

Tat-Beclin1 (TB1), which binds human immunodeficiency virus-1 Nef, is a potent inducer of autophagy. We investigated the therapeutic potential of TB1 in the heart during pressure overload (PO). At baseline, treatment of cardiomyocytes (CMs) with 25 μM TB1 significantly increased both GFP/RFP double positive (Yellow) LC3 puncta (8.3±1.1 vs 1.4±0.2, P&lt;0.05) and RFP LC3 puncta (4.2±1.1 vs 1.5±0.3, p&lt;0.05) compared to treatment with Tat-scrambled (TS). After treatment for 2 weeks with TB1 or TS at 20 mg/kg daily, GFP-LC3 puncta were significantly increased in mouse hearts with TB1 compared to those with TS, with (31.6±5.0 and 20.3±5.9, p&lt;0.05) or without chloroquine (21.7±4.3 and 8.1±2.2, p&lt;0.05), indicating that TB1 stimulates autophagy in the heart. We investigated whether lysosomal clearance of mitochondria, reflecting mitochondrial autophagy, is stimulated by TB1, using Mito-Keima. Puncta with a high ratio of excitation at 560/440 nm co-localized with Alexa 488 Dextran, reflecting lysosomal localization of Mito-Keima, were significantly increased after TB1 compared to after TS treatment (5.68±1.18 vs 1.37±0.76, p&lt;0.05). In order to evaluate the effect of TB1 upon the heart during PO, C57BL/6J mice were subjected to i.p. injections of TB1 or TS for 2 weeks, and the mice were sacrificed after 1 week. Ejection fraction (EF) was maintained (78.3±1.2 vs 63.3±3.0, p&lt;0.05), lung weight/tibial length was lower (7.9±0.3 vs 8.2±0.2, p&lt;0.05), the pressure gradient was greater (89.3±4.4 vs 71.8±4.3, p&lt;0.05), and the end diastolic pressure (EDP) was lower (8.2±0.9 vs 11.5±1.5, p&lt;0.05) in TB1- than in TS-treated mice. Mitochondrial ATP production was better preserved in TB1- than in TS-treated mice (1.72±0.16 vs 1.00±0.16, p&lt;0.05). Mitochondrial DNA content (0.54±0.05 vs 1.00±0.11, p&lt;0.05) and the Cox1 level in mitochondria (0.47±0.11 vs 1.00±0.18, p&lt;0.05) were lower in TB1- than in TS-treated mice, consistent with increased degradation of mitochondria. In EM analyses of the mouse heart, autophagosomes containing mitochondria were observed after TB1 treatment, but not TS treatment. These results suggest that TB1 induces general autophagy and mitophagy in the heart and acts protectively against cardiac dysfunction after PO.
Electrical Injuries
Authors: W Mills, W E Switzer, J A Moncrief
Journal: JAMA (1966)

Electrical injuries constitute an important, distinctive, but often poorly understood, variety of trauma. In our complex society, and home utilization of electric power, we are continually faced with a significant incidence of electrical accidents, and their morbidity and mortality are high. It has been estimated that approximately 1,100 electrical fatalities now occur annually in this country. Most physicians are aware that electrical burns differ from ordinary thermal injuries of other etiologies, but the specific manner in which they are dissimilar is frequently not understood. Electrical burns present certain distinctive pathological and clinical features, knowledge of which is important for their proper management. The purpose of this scientific exhibit, presented at the recent convention of the American Medical Association in New York, was to stress the pathophysiology, clinical manifestations, and management of electrical injuries by means of illustrative photographs derived from clinical material at our Burn Center (US Army Surgical Research
Nephron, A Journal of Nephrology
Authors: E. J. H.
Journal: Annals of Internal Medicine (1965)

Editorials1 February 1965Nephron, A Journal of NephrologyE. J. H.E. J. H.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-2-413 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt is proper that the newest journal to roll onto my desk from the growing stream of medical publishing is Nephron, concerned obviously with that structure that generates its own yellow rivulet. Serving as organ—but of communication—for the International Society of Nephrology, this journal will pass information on the normal and abnormal kidney among the islands of disciplines—physiology, pathology, clinical observation—and from country to country.ThatNephronwill, indeed, be aninternationaljournal seems to be assured by the selection of its distinguished editors and associate editors from antipodal Melbourne and Stockholm and many points between. The American representatives are... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1965Volume 62, Issue 2Page: 413-413KeywordsClinical pathologyKidneysNephrologyNephronsRivers ePublished: 1 December 2008 Issue Published: 1 February 1965 PDF downloadLoading ...
BACTERIOLOGIC RELATIONS OF THE BILE.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Deaths
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
How Physicians Identify Victims of Domestic Violence
Journal: Annals of Internal Medicine (1999)

Summaries for Patients19 October 1999How Physicians Identify Victims of Domestic ViolenceSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-131-8-199910190-00040 SectionsAboutFull Text ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Unfortunately, domestic violence (physical abuse by family members or domestic partners) is a common problem. Domestic violence can have bad effects on physical and psychological health. Yet persons who are abused often do not tell their doctors about it because they are afraid, embarrassed, do not think of it as a health problem, or do not think doctors would be able to help them. Also, many doctors do not ask about this problem because they forget, find the subject is uncomfortable, or believe that there is little they ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “A Qualitative Analysis of How Physicians with Expertise in Domestic Violence Approach the Identification of Victims.” It is in the 19 October 1999 issue of Annals of Internal Medicine (volume 131, pages 578-584). The authors are B. Gerbert, N. Caspers, A. Bronstone, J. Moe, and P. Abercrombie.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoA Qualitative Analysis of How Physicians with Expertise in Domestic Violence Approach the Identification of Victims Barbara Gerbert , Nona Caspers , Amy Bronstone , James Moe , and Priscilla Abercrombie Metrics 19 October 1999Volume 131, Issue 8Page: 578KeywordsDomestic violenceEmergency department ePublished: 15 August 2000 Issue Published: 19 October 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.Loading ...
ANNIVERSARY OF THE NATIONAL NUTRITION CONFERENCE
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Urinary leukocyte esterase screening test for asymptomatic chlamydial and gonococcal infections in males
Authors: M. A. Shafer
Journal: JAMA (1989)

We evaluated the ability of the urinary leukocyte esterase test to predict culture-verified chlamydial and gonococcal urethritis among asymptomatic adolescent males. Nine hundred forty-eight sexually active males provided first-catch urine samples for esterase screening, and 76 (8%) tested positive (≥1 + ). Among 435 boys who agreed to undergo urethral culture, the esterase was positive in 66 (15%),<i>Chlamydia trachomatis</i>was isolated from 39 (9%), and Neisseria gonorrhoeae was isolated from 14 (3%). The sensitivity, specificity, and positive and negative predictive values for the esterase test were 72%, 93%, and 58% and 96%, respectively. Using the esterase test to screen asymptomatic males for urethritis, we identified 38 culture-verified infections that otherwise would have remained undetected. The urinary leukocyte esterase test is a noninvasive and cost-effective screening method to detect urethritis among asymptomatic adolescent males. (<i>JAMA</i>. 1989;262:2562-2566)
The Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering (MIRACL) Trial: Effects of Intensive Atorvastatin Treatment on Early Recurrent Events After an Acute Coronary Syndrome
Authors: G. G. Schwartz, A. G. Olsson, M. D. Ezekowitz, P. Ganz, M. F. Oliver, D. Waters, A. Zeiher, B. Chaitman, S. Leslie, T. Stern
Journal: Circulation (2000)
How Physicians Can Become Better Public Speakers: Part 1
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE VACCINATION QUESTION.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Update: Human Plague—India, 1994
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Proteomic Markers of DNA Repair and PI3K Pathway Activation Predict Response to the PARP Inhibitor BMN 673 in Small Cell Lung Cancer—Response
Authors: Robert J.G. Cardnell, Lauren A. Byers
Journal: Clinical Cancer Research (2014)

In a Letter to the Editor about our recent publication (1), Haifeng Qiu suggests that further clarification is needed about the relationship between sensitivity to BMN 673 and dysregulated PI3K/mTOR signaling, given the potential association between PTEN loss and PARP inhibitor sensitivity in other cancer types.Although we agree that PTEN inactivation is common in human malignancies and may be associated with sensitivity to PARP inhibitors in some cancers, PTEN loss is only one of several possible mechanisms by which the PI3K/mTOR pathway can be activated, each of which may have different implications for drug sensitivity. For small cell lung cancer (SCLC), this distinction was illustrated in a recent publication (2) that showed activity of a selective oral phosphoinositide 3-kinase (PI3K) inhibitor, PF-4989216, in SCLC preclinical models harboring activating PIK3CA mutations, but not PTEN loss.Genomic analysis by Peifer and colleagues (3) indicates that PTEN loss occurs in a minority of SCLC tumors (10%). Of the cell lines used in our analysis, only one—NCI-H2081—carries a PTEN mutation and this cell line was not included in the proteomic analysis. The H2081 cell line fell in the middle of the range of sensitivities to BMN 673 (6.3 nmol/L; IC50 range, 1.7–15 nmol/L), suggesting that PTEN deficiency was not responsible for the observed sensitivity of our SCLC cell lines to BMN 673, nor was it the cause of greater PI3K/mTOR pathway activation observed in the more resistant lines.As described in Dr. Qiu's letter, an association between PTEN deficiency and PARP inhibitor sensitivity has been described in other cancers, including breast, prostate, and endometrial cancers. However, even among cancers with PTEN loss, there are likely to be additional factors that affect sensitivity, as suggested by a recent study that showed sensitivity of tumors with PTEN loss was dependent on levels of circulating estrogen (4). Furthermore, the potential benefit of dual PARP–PI3K pathway inhibition has also been suggested in breast cancer based on preclinical models of triple-negative and BRCA-mutated breast cancers (5) and is being explored in an ongoing clinical trial.In conclusion, we agree with Dr. Qiu that the connection between PARP inhibitors and the PI3K/mTOR pathway warrants further exploration. However, our data indicate that the association between baseline PI3K/mTOR pathway activity and in vitro activity of BMN 673 is independent of PTEN and suggests a distinct mechanism of PARP inhibitor activity in SCLC.See the original Letter to the Editor, p. 2236L.A. Byers has received clinical trial funding and is an advisory board member for BioMarin. No potential conflicts of interest were disclosed by the other author.
Sex Differences in Revascularization
Authors: William A. Ghali
Journal: Annals of Internal Medicine (2003)

Letters4 February 2003Sex Differences in RevascularizationWilliam A. Ghali, MD, MPHWilliam A. Ghali, MD, MPHUniversity of Calgary; Calgary, Alberta T2N 4N1, Canada (Ghali)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-138-3-200302040-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Dr. Groeneveld is correct to suggest that administrative data can often be used to generate useful information on disparities in access to care. He is also correct in highlighting that the need for detailed clinical information may not apply to all administrative databases nor to all potential research questions on issues of access and disparity of care. Given these valid comments, the challenge for researchers and readers then becomes how to know when an analysis is applying sufficiently detailed data to make meaningful conclusions.Dr. Groeneveld has made two concrete recommendations: 1) Researchers should vigilantly identify and report ... Author, Article, and Disclosure InformationAffiliations: University of Calgary; Calgary, Alberta T2N 4N1, Canada (Ghali) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoSex Differences in Access to Coronary Revascularization after Cardiac Catheterization: Importance of Detailed Clinical Data William A. Ghali , Peter D. Faris , P. Diane Galbraith , Colleen M. Norris , Michael J. Curtis , L. Duncan Saunders , Vladimir Dzavik , L. Brent Mitchell , Merril L. Knudtson , and Sex Differences in Revascularization Peter W. Groeneveld Metrics 4 February 2003Volume 138, Issue 3Page: 237KeywordsDatabasesHealth careHealth disparitiesHealth information technologyInformation storage and retrievalMultivariate analysisRevascularization ePublished: 4 February 2003 Issue Published: 4 February 2003 CopyrightCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
PHOSPHORUS IN RICKETS
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal