tbuckley/cabot-search huggingface dataset:
Rheumatic Polytendovaginitis
Authors: I. L. Sperling
Journal: Annals of the Rheumatic Diseases (1950)

Inflammatory changes in the tendon sheaths are recognized as a common accompaniment of many rheumatic diseases (Sperling, 1949).In rheumatoid arthritis this is a part of the general rheumatic involvement.Baumgartner (1946) pointed out that the rheumatic picture may present itself primarily with tendon sheath involvement.This picture is apparently rare, with few reports in the literature.For that reason the following case history is given in detail. Case HistoryThe patient, a 45-year-old white, married man, was first seen on Nov. 12, 1948, with a fifteen-year history of progressive development of nodulations over the finger joints, thickening of the palms, and generalized joint pain.The history revealed nothing important, and there had been no gonorrhoea.He had been a heavy drinker for many years, but had stopped five years previously.He was a mechanical engineer, but had recently, up to the time of his hospitalization, worked as a house painter.Fifteen years previously he noted a swelling over the dorsum of the proximal interphalangeal joints of the right index finger.This gradually became nodular and was associated with a mildly painful swollen joint.He gradually developed swellings over the proximal interphalangeal joints of many fingers of both hands, chiefly on the dorsum but also anteriorly (Fig. 1, p. 45).During this period he described " bumps " which came and went over the dorsum of the extensor surface of the forearm at the elbow.Five years before he was seen, thickening of the palms had begun, with gradual extension into the fingers on the medial side of the palm (Fig. 2, p. 45).Recently he had developed a nodular swelling over the right infra-patellar area.During this period there were periodical regressions and recurrence of these infiltra- tions and swellings for variable periods, with eventual increased extension.He also had generalized aches and pains in the shoulders, knees, wrists and feet.These were not associated with swelling, redness, or increased joint temperatures.The pains were dull, worse in the morning or after excessive activity.Movement of the joints caused only slight increase in the pain.Periodically there were pains and swelling of the elbows with some restricted motion.A year and a half before he was seen, following a bout of biliary obstruction with jaundice, a cholecystectomy was performed.The jaundice remained for almost a month, and during this period he had complete relief from joint pains and stiffness with marked recession of the finger nodules.Several months later the swellings and symptoms recurred.Before hospitalization, following heavy physical effort, he developed severe pains in the shoulders, ankles, and knees.Examination.-Thepatient was a well-developed white male, rather distressed and apprehensive.There was a small non-tender nodule over the sixth cervical spine.The shoulders were slightly painful on movement.There was tenderness above and below 43
Pretransplantation clinical status and outcome of emergency transplantation for acute liver failure
Authors: J DEVLIN
Journal: Hepatology (1995)

Emergency transplantation for acute liver failure has a significantly inferior outcome than transplantations performed for elective indications. The severity of the pretransplantation clinical illness in this group will contribute to the reduced patient survival. We have reviewed the outcome of our first 100 consecutive adult patients who received transplants for acute liver failure and have evaluated and determined which recipient clinical parameters present on admission and at transplantation act as risk factors in early posttransplantation outcome. In patients who received transplants for nonacetaminophen-induced liver failure (n = 79), no static variable determinable on admission (including age, sex, year of transplantation, hospital admission to transplantation period, and fulminant or late-onset presentation) other than cause was predictive of 2-month patient survival. Fulminant Wilson's disease and idiosyncratic drug reactions with 2-month survival rates of 100% and 12.5%, respectively, had significantly different outcomes from other causes. By the time of transplantation, of four dynamic variables significant in a univariate analysis (serum creatinine, encephalopathy grade, Apache 111 and organ system failure scores, and P values < .05), only the creatinine level was an independent variable in a stepwise logistic regression for 2-month survival (r = .33). In patients who received transplants for acetaminophen hepatotoxicity (n = 21), overdose to hepatectomy period was the only significant static variable, with no parameter predictive of outcome present on admission. Of two dynamic variables that were significant at transplantation (serum bilirubin and Apache 111 score, P < .05) only the latter parameter was an independent variable in the regression model (r = .51). Selection of candidates experiencing acute liver failure for transplantation depends on assessment of both the prognosis of the primary hepatic illness on admission and, for a successful outcome, the clinical status at the time of proposed grafting. (HEPATOLOGY 1995; 21:1018–1024.)
Lifetime benefits and costs of intensive therapy as practiced in the diabetes control and complications trial. The Diabetes Control and Complications Trial Research Group
Journal: JAMA (1996)

To examine the cost-effectiveness of alternative approaches to the management of insulin-dependent diabetes mellitus (IDDM).A Monte Carlo simulation model was developed to estimate the lifetime benefits and costs of conventional and intensive insulin therapy. Data were collected as part of the Diabetes Control and Complications Trial (DCCT) and supplemented with data from other clinical trials and epidemiologic studies.Twenty-nine academic medical centers.Persons with IDDM in the United States who meet demographic and clinical eligibility criteria for enrollment in the DCCT.Conventional vs intensive diabetes management.Approximately 120 000 persons with IDDM in the United States meet DCCT eligibility criteria. Implementing intensive rather than conventional therapy in this population would result in a gain of 920 000 years of sight, 691 000 years free from end-stage renal disease, 678 000 years free from lower extremity amputation, and 611 000 years of life at an additional cost of $4.0 billion over the lifetime of the population. The incremental cost per year of life gained is $28 661.Over a lifetime, DCCT-defined intensive therapy reduces complications, improves quality of life, and can be expected to increase length of life. From a health care system perspective, intensive therapy is well within the range of cost-effectiveness considered to represent a good value.
Measurement in Clinical Respiratory Physiology
Journal: Thorax (1985)

<b>Aim:</b> Evaluate the influence of socioeconomic factors on visual acuity (VA) at presentation in exudative age-related macular degeneration (AMD). <b>Methods:</b> The medical records of all consecutive patients with newly diagnosed exudative AMD examined at the Ophthalmology Departments of Grampian University Hospitals-NHS Trust, Aberdeen, and Gartnavel General Hospital, Glasgow, between July-2004 and June-2005, were reviewed. Demographics, duration of symptoms, VA in study and fellow eye, exudative AMD characteristics, status of fellow eye, and patient home address, used to determine the Scottish Index of Multiple Deprivation (SIMD) score, were recorded. The effect of these parameters on VA at presentation was investigated using general linear modelling. <b>Results:</b> Two-hundred and forty patients (median age 79 years) were included in this study; forty-four (18.3%) belonged to the lowest 20% SIMD score (most deprived). Age and location and type of the choroidal neovascularization were statistically significantly associated with VA at presentation (p = 0.003, p &lt; 0.001, and p &lt; 0.001 respectively). Neither SIMD scores (p = 0.959 ), area (Glasgow/Aberdeen) (0.247) or VA in the fellow eye (p = 0.056) were associated with presenting vision. <b>Conclusions:</b> Age, location and type of CNV, but not socio-economic deprivation were associated with VA at presentation in exudative AMD.
PLoS Medicine Issue Image | Vol. 2(10) October 2005
Journal: PLoS Medicine (2005)

Rob Frankle is an illustrator and graphic designer. In both disciplines, his goal is to communicate issues with simplicity and psychological impact. He believes that the process of painting is a dialogue between external and internal reality. From childhood, he has always been fascinated with how marks on paper can often reach below the surface of experience and connect with viewers. In this painting, Frankle focuses on the common yet not fully understood condition we call "dementia." The main symptom of dementia is an acute decline in mental ability. With this, an upheaval of personal reality occurs. One's normal construct of time and place often dissolves. Dementia dramatically reveals to us the critical nature of brain function in defining our reality. Frankle holds a B. F. A. degree from The Cooper Union for the Advancement of Science and Art and resides in Brewster, New York. Image Credit: Rob Frankle (www.robfrankle.com)
Parallel synthesis with fluorous reagents and reactants
Authors: Dennis P. Curran
Journal: Medicinal Research Reviews (1999)

Fluorous reagents and reactants provide emerging new options in parallel synthesis because they are easily prepared, reacted, and then separated from the desired reaction products. Some background information on fluorous reaction and separation techniques is provided, and the utility of fluorous reagents and reactants is illustrated with a number of case studies that feature both liquid-liquid and solid-solid separations. © 1999 John Wiley & Sons, Inc. Med Res Rev, 19, No. 5, 432–438, 1999.
Vasopressin gene expression in rats with experimental cirrhosis
Authors: J Kim
Journal: Hepatology (1993)

Impaired ability to excrete a water load occurs in a substantial number of patients with advanced cirrhosis and in animals with experimental cirrhosis. The nonosmotic stimulation of arginine vasopressin release from the pituitary has been implicated as an important factor in the abnormal water excretion in patients and animals with cirrhosis. In this study, arginine vasopressin hypothalamic gene expression was studied in cirrhotic rats. Cirrhosis was induced by a combination of phenobarbital treatment in drinking water and weekly intragastric administration of carbon tetrachloride for 13 to 15 wk. Severe cirrhosis was confirmed by morphological analysis and the presence of ascites. Plasma arginine vasopressin was also significantly higher in rats with cirrhosis (control = 1.77 ± 0.16 and cirrhotic rats = 4.14 ± 0.62 pg/ml, n = 9, p < 0.002). Hypothalamic arginine vasopressin messenger RNA was also significantly higher in cirrhotic rats (control = 762.1 ± 132.3 and cirrhotic rats = 1,834.2 ± 271.9 pg/hypothalamus, n = 9, p < 0.005). Pituitary arginine vasopressin content was significantly lowered in cirrhotic rats (control = 3.69 ± 0.98 and cirrhotic rats = 1.57 ± 0.09 μg/pituitary, n = 9, p < 0.05). No difference was seen in hypothalamic arginine vasopressin content between the two groups (control = 4.64 ± 0.34 and cirrhotic rats = 4.23 ± 0.33 ng/hypothalamus, n = 9, NS). Oxytocin messenger RNA in the hypothalamus was also not significantly different between the two groups (control = 8.61 ± 0.68 and cirrhotic rats = 9.33 ± 0.65 unit of density, n = 9, NS). No differences were seen in plasma sodium (control = 145.7 ± 1.62 and cirrhotic rats = 145.9 ± 1.09 mmol/L), plasma osmolality (control = 296.6 ± 2.6 and cirrhotic rats = 297.1 ± 4.2 mOsm/kg H2O), creatinine clearance and blood urea nitrogen between the two groups. These results therefore provide support for increased hypothalamic biosynthesis and pituitary release of arginine vasopressin in experimental cirrhosis in the rat. (HEPATOLOGY 1993;17:143–147.)
Encephalitis and Poliomyelitis in the Adult Due to Coxsackie Virus, Group B, Type 5
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Organ donor recruitment. Council on Scientific affairs
Journal: JAMA (1981)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Video Comment on Attam R et al.
Journal: Endoscopy (2015)

See also: EUS-guided sutured gastropexy for transgastric ERCP (ESTER) in patients with Roux-en-Y gastric bypass: a novel, single-session, minimally invasive approachEndoscopy 2015; 47(07): 646-649DOI: 10.1055/s-0034-1391124
MAGNESIUM SULPHATE SOLUTION AS AN AID IN ANESTHESIA
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Highlights from this issue
Authors: Emad El-Omar, Alexander Gerbes, William Grady, Thomas Rösch
Journal: Gut (2014)

LUMINAL PPI and community acquired pneumoniaPrevious observational studies have found that PPI's are associated with an increased risk of hospitalisation for communityacquired pneumonia (HCAP).However, these studies are confounded by gastroesophageal reflux disease and protopathic bias.Such confounders could be overcome by studying patients prescribed PPI's as prophylaxis for NSAIDs.In this issue of Gut, Filion et al performed one of the largest studies ever on this subject.They formed eight restricted cohorts of new users of NSAIDs, aged ≥40 years, using a common protocol in eight databases (Alberta, Saskatchewan, Manitoba, Ontario, Quebec, Nova Scotia, US MarketScan and the UK's General Practice Research Database (GPRD)).After adjustment, PPIs were not associated with an increased risk of HCAP (OR=1.05;95% CI 0.89 to 1.25).Histamine-2 receptor antagonists yielded similar results (OR=0.95,95% CI 0.75 to 1.21) suggesting a lack of dose-response relationship between potency of gastric acid suppression and the risk of HCAP (table 1).The authors conclude that concerns regarding HCAP should not influence prescribing of gastric acidsuppressing medications.
Increased Cholecystectomy Rate After Introduction of Laparoscopic Cholecystectomy
Authors: David A. Foster
Journal: JAMA (1994)

<h3>To the Editor.</h3> —In their article, Legorreta et al<sup>1</sup>suggest that the introduction of laparoscopic cholecystectomy may have caused an increase in the overall consumption of health care resources. They base their conclusion on an apparent increase of almost 60% from 1988 through 1992 in use rates for cholecystectomy from a 500 000-enrollee health maintenance organization (HMO) in southeastern Pennsylvania. While the studied data may be an accurate reflection of one HMO's claims experience, these findings are not supported by an examination of cholecystectomy utilization in three different national data sets. In order to determine whether such an increase in cholecystectomy rates can be generalized to the nation, we analyzed all-payer data from the National Hospital Discharge Survey (NHDS),<sup>2</sup>Medicare data from the Health Care Financing Administration (HCFA), and hospital discharge data compiled by the HCIA in conjunction with the Commission on Professional and Hospital Activities. Our analysis
Collateral Susceptibility of Isoniazid-Resistant Tubercle Bacilli to Nitrofurans
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
KARL A. VON BASEDOW (1799-1854)
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
Authors: Martin D. Young
Journal: JAMA (1952)

<h3>To the Editor:—</h3> I have read in the May 10 issue ofThe Journal, page 169, the editorial entitled "Eradication of Malaria." I should like to congratulate you on the excellence of this editorial, which is in keeping with editorials on the same subject in recent years in your journal. I should like to point out an error in the reference to Dr. Russell's article, the reference being listed as The American Journal of Tropical Medicine, volume 1, 1952. The name of the journal is incorrect. There is no longer an American Journal of Tropical Medicine, as the society, along with the National Malaria Society, was dissolved at the Chicago meeting in November, 1951. A new society was formed by the amalgamation of the National Malaria Society and the American Society of Tropical Medicine, which new society is known as the American Society of Tropical Medicine and Hygiene. It publishes
What are physicians for?
Authors: R. A. Carson
Journal: JAMA (1977)

To make this interaction (between doctor and patient) as productive as possible in terms of the relief of human suffering is the object of everything we do in medicine.<sup>1</sup> WHAT are physicians for? Does anyone know the answer to this question anymore? One reads and hears a variety of answers, from the very narrow to the extremely broad. Physicians, some argue, should attend to what they know best. The proper business of medicine is pathology, the diagnosis and treatment of disease. Others argue that disease must be seen contextually, as belonging to a whole human being who is a part of a web of relationships, who holds a certain job, has responsibilities, shares this belief system and not that, and so on. For the disease-oriented physician, this latter approach only clutters the mind and confuses the issue. For the advocate of the whole-man approach, focusing on disease alone is