tbuckley/cabot-search huggingface dataset:
Influence of baseline resistance on treatment outcome in patients treated for chronic hepatitis C in Denmark: a nationwide study
Authors: Ulrik Fahnøe, Martin Schou Pedersen, Christina Sølund, Sofie Hallager, Anja Ernst, Henrik Krarup, Birgit Thorup Røge, Peer Brehm Christensen, Alex Laursen, Jan Gerstoft, Peter Thielsen, Lone Madsen, Anders Gorm Pedersen, Kristian Schønning, Nina Weis, Jens Bukh
Journal: Journal of Hepatology (2020)
Codeine caused pruritic scarlatiniform exanthemata: patch test negative but positive to oral provocation test
Authors: M. Mohrenschlager, A. Glockner, B. Jessberger, W.I. Worret, M. Ollert, J. Rakoski, J. Ring
Journal: British Journal of Dermatology (2000)

Sir, Codeine was first extracted from opium in 1832, and in 1882 its chemical formula was determined to be the methyl ester of morphine. Despite extensive use as an analgesic and antitussive drug, clear‐cut cases of codeine‐induced exanthemata are rare.1 Török, in a 10‐year observation period of ‘dermatitis medicamentosa’, found only 15 of 1303 cases to be elicited by codeine.2 We report the case of a 58‐year‐old non‐atopic male Caucasian who developed a pruritic rash affecting body and face and periorbital swelling 3 h after the ingestion of codeine 20 mg, acetylcysteine 600 mg and acetylsalicylic acid 500 mg because of influenza. There was no other history of allergic drug reactions. Previous intake of the medication had been well tolerated. The patient reported to our allergy unit 10 months later. Clinical examination demonstrated an obese patient (body mass index (BMI) 27·1 kg m−2 normal BMI range, 18·5–24·9 kg m−2) with normal appearing skin.
PUBLIC HEALTH.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Acute cerebellar ataxia associated with Epstein-Barr virus infection
Authors: T. G. Cleary
Journal: JAMA (1980)

MENINGOENCEPHALITIS, Bell's palsy, transverse myelitis, and Guillain-Barré syndrome has been associated with infectious mononucleosis. Recently, patients with these neurologic complications have had serologic studies performed that link these conditions to Epstein-Barr virus (EBV) infections.<sup>1,2</sup>The association of acute cerebellar ataxia with infectious mononucleosis is rare in adults<sup>3-9</sup>and children,<sup>10</sup>and patients with this condition have not had extensive serologic confirmation of EBV infections. We describe here a child who had an EBV infection manifesting as acute cerebellar ataxia. <h3>Report of a Case</h3> A 7-year-old girl was admitted to the pediatric service of the University of Texas Medical School, Houston, with a four-week history of increasing clumsiness and ataxia. Several days prior to the development of difficulty walking, she had complained of headache, nausea, and vomiting. She did not have sore throat, fever, or rash. The only medication she was receiving was aspirin. Physical examination showed a temperature
Dermatology
Authors: J. G. Smith
Journal: JAMA (1980)

In a supplemental issue of the<i>Journal for Investigative Dermatology</i>, a National Institutes of Health (NIH) contract-supported analysis of research needs and priorities in dermatology has been published.<sup>1</sup>The work was edited by Kenneth K. Kraning and George F. Odland of the University of Washington, Seattle, with the aid of a coordinating committee. More than 100 investigators in 12 study groups critically evaluated areas of major importance in skin disease. The current status of knowledge concerning prevalence, morbidity, costs, pathogenesis, and therapy of cutaneous disorders was reviewed. <h3>Major Problems</h3> What are some of the major problems? At least 60 million Americans show objective evidence of skin disease serious enough to warrant consultation by a physician. Based on the Health and Nutrition Examination Survey (HANES-1) of a sample of 20,749 Americans aged 1 to 74 years, the activity of an estimated 2 million people in the United States is limited by
Cesarean section rates in the United States
Journal: JAMA (1985)

<h3>To the Editor.—</h3> The recent study by Gleicher<sup>1</sup>and the comments on it by Dr Rosen<sup>2</sup>are most interesting. It appears that all studies on cesarean delivery will be incomplete until the publication of a well-designed study relative to the influence of litigation on the obstetrician's choice of procedure. The consensus conference of 1980 was unable to reach any firm conclusion in this area. This is because there are very few data on this important subject. When the average obstetrician is faced with a large neonate in the occiput posterior position and a questionable fetal heart tracing, it is much easier for him to do a cesarean than it is to stand by and wait for vaginal delivery—knowing that 20 years hence (when he is in his old age) he may well be the object of a malpractice suit by the child he is about to deliver. Such
Hyperkalemia in Elderly Patients Receiving Standard Doses of Trimethoprim-Sulfamethoxazole
Authors: Ira W. Reiser
Journal: Annals of Internal Medicine (1994)

Letters1 March 1994Hyperkalemia in Elderly Patients Receiving Standard Doses of Trimethoprim-SulfamethoxazoleIra W. Reiser, MD and Shyan-Yih Chou, MDIra W. Reiser, MDThe Brookdale Hospital Medical Center; Brooklyn, NY 11212Search for more papers by this author and Shyan-Yih Chou, MDThe Brookdale Hospital Medical Center; Brooklyn, NY 11212Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-120-5-199403010-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Before receiving the above correspondence, we were unaware of any case reports in which administration of trimethoprim-sulfamethoxazole in standard doses (160 mg of trimethoprim and 800 mg of sulfamethoxazole given twice daily) has been implicated as a cause of hyperkalemia. In fact, of the 649 patients who received trimethoprim-sulfamethoxazole in standard doses and who were monitored within a hospital setting in the Boston Collaborative Drug Surveillance Program, none developed hyperkalemia [1]. Trimethoprim-sulfamethoxazole inhibits amiloride-sensitive sodium channels in the distal nephron and reduces the transepithelial voltage favoring potassium secretion in a dose-dependent fashion [2, 3]. Standard twice-daily doses of ...References1. Lawson DH, Jick H. Adverse reactions to co-trimoxazole in hospitalized medical patients. Am J Med Sci. 1978; 275:53-7. Google Scholar2. Choi MJ, Fernandez PC, Patnaik A, Coupaye-Gerard B, D'Andrea D, Szerlip H, et al. Trimethoprim-induced hyperkalemia in a patient with AIDS. N Engl J Med. 1993; 328:703-6. Google Scholar3. Velazquez H, Perazella MA, Wright FS, Ellison DH. Renal mechanism of trimethoprim-induced hyperkalemia. Ann Intern Med. 1993; 119:296-301. Google Scholar Author, Article, and Disclosure InformationAffiliations: The Brookdale Hospital Medical Center; Brooklyn, NY 11212 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1994Volume 120, Issue 5Page: 437-438KeywordsAttentionDrugsElderlyExcretionNephronsPotassiumProspective studiesSodium channels ePublished: 15 August 2000 Issue Published: 1 March 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Lonely in Paris: when one gene copy isn't enough
Authors: R. A. Shivdasani
Journal: Journal of Clinical Investigation (2004)

Circulating platelets are continually replenished by fragmentation of terminally differentiated megakaryocytes. Processes disrupted in inherited thrombocytopenias frequently shed light on normal thrombopoietic mechanisms. An especially rare condition called Paris-Trousseau syndrome (PTS) seems to occur by virtue of hemizygous loss of the FLI1 transcription factor gene. Provocative new data suggest that FLI1 shows monoallelic expression during a brief window in megakaryocyte differentiation, which thus explains the dominant inheritance pattern of PTS despite the presence of one normal FLI1 allele .
A Post-Graduate Lecture on the Influence of the Arterioles in Relation to Various Pathological Conditions
Authors: G. Johnson
Journal: BMJ (1894)

IN'FL'JUENCE OF TlIIE ARTERIOL.ES.periments were condued (, t}le observatioil of t}le blood pre^ssure wiis somnewhat interfered wit}l by tliesuldlei varia- tiois w}liiPli l(esulte'd frojI t}sC violellt respiratory eforts; of tlle suffocated animnals; but Mr. Erielisen' subsequentlYr, 'in a series of Iiiglily iiistructive experiments, got rid of thiis disi- turbing element by elividing the spinal cord as near to the craiiium as p)os,;ibl, tlle aiiimals t}len being kept alive for a time by atificial -e^spiratioui.The resultsobtandb }i metlio of expprimenting were in entire agreemenlt wit]i thlose of Dr. Rleid., It is a well-known fact tllat iiew r-born animals bear tile exclusioil of air niucli longer thantle samle class of animals a few daysB older.Thus Dr. M. Foster 8jays,7 4 while in a full- grown dofg iecovery from drowning is unuisual after one minute and a-half, a newborn.puppyhas been known to bear an immersion of as mucli as fifty minutes; " and lie goes On to say: II The cause of tlsi i difftrence lies in the fact that in tlle quite young or ratlier just born animal the respiratory clianges of tlle tissues are much less active.Tlsese consume less oxygen, and t}1e general store of oxygen.in the blood has a less rapid demand iiiade upon it."There isproliabl some truti in tllis statement, but the explan'at'ion ignores;trie fact that in these animals for some days after birth, and so long as their eyes remain closed, the foramen ovale i'sopen, so that when air is excluded from the lungs the bliood passes directly, as in tlse fcetus, from tlle riglit to the left side of the heart, and so escapes the controlling influence of the pul- monary vessels.Mr. Erichsen performed some interesting experiments on- these newly-boi n animals, and found tllat not only did the circulation continue much longer after the exclusion of air than in older animals, but when the cheat was opened after- death there was no distenasion on the venous side of the lieart, and the amount of blood on tlle two sides was nearly equal.The description and explanation of the process of apncea which had been published b"y Dr. John Reid and Mr. Erichsen were generally accepted by physiologists.and
A NAVAL FIELD HOSPITAL.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medical News.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
High dose R-Apo-A-Imilano mobilizes tissue cholesterol and reduces plaque-lipid and macrophages within 48 hours: Implication for rapid plaque stabilization Prediman K. Shah, Juliana Yano, Charles L. Bisgaier, Odette S. Reyes, X. Helen Xu, M.k. McMurty, S. Drake, Sanjay Kaul, Kuang-Yuh Chyu, Bojan Cercek. Atherosclerosis Research Center, Cedars-Sinai Medicla Center, Los Angeles, CA, Esperion Therapeutics, Inc, Ann Arbor, MI
Journal: Journal of the American College of Cardiology (2001)
THE SIMILARITY OF SERUM COMPLEMENT AND THE DIGESTIVE ENZYMES.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Weather Forecast: Hot, Sunny—and Cover Up!
Authors: Charles Marwick
Journal: JAMA (1994)

SUN WORSHIPERS in 58 US cities no longer need guess about avoiding overexposure to skin cancer—promoting ultraviolet (UV) light. The National Weather Service is testing a program whereby local weather reports include a daily solar warning index: the likely exposure to UV radiation at noon each day in specific locations. The service will eventually cover the United States. The effort, developed by the Environmental Protection Agency (EPA), National Oceanic and Atmospheric Administration, and Centers for Disease Control and Prevention, is in response to the increasing incidence in Americans of skin cancer, cataracts, and other harmful effects of too much sun. The American Cancer Society estimates that 700 000 cases of basal cell and squamous cell skin cancer will be diagnosed here this year (leading to 2300 deaths, although such cancers are highly treatable) and 32000 cases of malignant melanoma (leading to 6900 deaths). Malignant melanoma, which occurs ten times as
From the Author
Authors: S. Suissa
Journal: European Respiratory Journal (2004)

bronchodilators (see SUISSA [1], p. 393, table 1, column 3).Comparison of table 1 in our study [2] and table 1 in SUISSA [1] shows that drug use was more irregular in the Saskatchewan database with low use of the recommended bronchodilators.In spite of this, S. Suissa9s own results using "very first regular exposure identified after diagnosis" in his "conventional intention-to-treat approach" still indicated a significant association between ICS use and mortality, rate ratio 0.75 (0.62-0.90).Furthermore, S. Suissa ignores that our study used two designs, a cohort approach for the main analysis and a nested case-control approach to explore a doseresponse relationship, with both methods indicating an association with ICS.The latter design has been described previously by SUISSA [5] as one that simplifies the cohort analysis when exposures vary over time and leads to valid estimates with negligible loss in precision.Finally, SUISSA [1] used a time-dependent exposure approach and obtained results, which suggested that inhaled corticosteroids were not better than bronchodilators at reducing the risk of death in chronic obstructive pulmonary disease patients.We are not surprised that the benefit of inhaled corticosteroids could not be established with the treatment switching approach.This methodology is known to be valid only if the reason for the switch to inhaled corticosteroids is unrelated to the patient9s subsequent risk of death [6].In our setting, the switch to inhaled corticosteroids was unlikely to be independent of mortality risk.Clinical experience suggests inhaled corticosteroids would be prescribed to sicker patients who were no longer responsive to bronchodilator therapy alone.
Platelet glycoprotein IIIa polymorphism is not a risk factor for target vessel revascularization after percutaneous revascularization Kimberly A. Skelding, Demetri Demetriou, Domnita Crisan, Laxmi Mehta, Judith A. Boura, Mark C. Pica, Debra A. Guido-Allen, Bohuslav Finta, Robert D. Safian, James A. Goldstein, Cindy L. Grines, William W. O'Neill. William Beaumont Hospital, Royal Oak, MI
Journal: Journal of the American College of Cardiology (2001)
Intravaginal estrogen creams and endometrial cancer: no causal association found
Authors: R. I. Horwitz
Journal: JAMA (1979)

In two case-control studies of estrogens and endometrial cancer, women were asked about previous use of intravaginal estrogen creams. In a set of cases and controls chosen by conventional procedures from a tumor registry, the odds ratio was 0.90. In an alternative set of cases and controls who had all received dilatation and curettage or hysterectomy, the odds ratio was 0.82. Despite the reported relationship between oral estrogens and endometrial cancer and although intravaginal estrogen creams are readily absorbed by the vaginal mucosa, we detect no causal association for their use. (<i>JAMA</i>241:1266-1267, 1979)
Compassion needs reason too
Authors: E. D. Pellegrino
Journal: JAMA (1993)

A GROWING number of physicians today believe that it is morally permissible, perhaps even required, to assist certain of their patients in the act of suicide.<sup>1-4</sup>They take their inspiration from Quill's account of the way he assisted his young patient, Diane, to kill herself.<sup>5</sup>They are impressed by Quill's compassion and respect for his patient. Like him, they would limit the physician's participation in suicide to extreme cases in which suffering is unrelenting, unrelievable, and unbearable. Like him, they follow a flawed line of moral reasoning in which a compassionate response to a request for assisted suicide is deemed sufficient in itself to justify an ethically indefensible act. See also pp 870 and 875. In his article<sup>6</sup>in this issue ofThe Journal, Quill provides a more formal and systematic outline of what he believes the appropriate response of physicians should be to a request for
Corrigendum to “EASL Clinical Practice Guidelines: Autoimmune hepatitis” [J Hepatol 2015;63:971–1004]
Authors: Ansgar Lohse, Olivier Chazouillères, George Dalekos, Joost Drenth, Michael Heneghan, Harald Hofer, Frank Lammert, Marco Lenzi
Journal: Journal of Hepatology (2015)
Chinese Journal of Integrated Traditional and Western Medicine
Authors: William Q. Wu
Journal: JAMA (1996)

This new title is actually the first English edition of a journal already distributed widely in Asia and published for 15 years in Chinese, Japanese, and Korean. The Chinese Association of the Integration of Traditional and Western Medicine and the China Academy of Traditional Chinese Medicine are joint sponsors. The 8× 11-in, two-column-format journal has few illustrations but many graphs and tables. The contents of each issue are well identified on the front cover and the first inside page. Consistent with the practice of new publications in China, the first issue contains photographs of a few prominent people with their statements of praise and of the honorary members of the Chinese Academy of Medical Science and the minister and vice minister of public health. The editorial board consists mostly of people from academic institutions in research and clinical practice. The physician member of this reviewing team has visited several of
Internal medicine chief residents want changes in education
Authors: P. G. Tuteur
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal