tbuckley/cabot-search huggingface dataset:
Right upper lobe mass in a shepherd
Authors: J. Dexter
Journal: JAMA (1981)

<h3>History</h3> A 44-year-old Basque man (13-year resident of southern California) was hospitalized because of a ten-day episode of cough, right-sided chest pain, and mild hemoptysis. He had been a shepherd in Spain as well as in southern California. His immigration chest x-ray film in 1965 was reported as "normal," and his history was otherwise noncontributory. An intermediate-strength (5-TU biological equivalent) skin test was nonreactive; a Casoni skin test reaction was negative; a complete blood cell count, including levels of eosinophils, was normal. Bilirubin and liver enzymes levels were normal. The liver-spleen scan did not demonstrate focal defects. Posteroanterior and lateral roentgenograms of the chest at the time of admission are shown in Fig 1 and 2. <h3>Section Coordinators:</h3> Thomas C. Beneventano, MD (Case of the Month); Juan A. del Regato, MD (Therapeutic Radiology); Jack Edeiken, MD (Diagnostic Radiology); Barry B. Goldberg, MD (Ultrasonography); E. Robert Heitzman, MD (Diagnostic Radiology); Stanley
Contents
Authors: Mi Lee, Sung-Il Cho, Ho Kim, Yun-Mi Song, Kayoung Lee, Jong-Il Kim, Dong-Myung Kim, Tae-Young Chung, Youn Kim, Jeong-Sun Seo, Don-Il Ham, Joohon Sung, Felipe Medeiros, Robert Weinreb, Grant Moore, Jeffrey Liebmann, Christopher Girkin, Linda Zangwill, Angelo Tanna, Donald Budenz, Jagadeesh Bandi, William Feuer, Robert Feldman, Leon Herndon, Douglas Rhee, Julia Whiteside-De Vos, Joyce Huang, Douglas Anderson, Raghavan Lavanya, Mani Do, Rajesh Baskaran, Hon-Tym Kumar, Ed Wong, Paul Chew, Paul Foster, David Friedman, Tin Aung, Jeremy Kieval, Carol Karp, Mohamed Shousha, Anat Galor, Rodrigo Hoffman, Sander Dubovy, Jianhua Wang, Yoshihiro Inamoto, Xiaoyu Chai, Brenda Kurland, Corey Cutler, Mary Flowers, Jeanne Palmer, Paul Carpenter, Mary Heffernan, David Jacobsohn, Madan Jagasia, Joseph Pidala, Nandita Khera, Georgia Vogelsang, Daniel Weisdorf, Paul Martin, Steven Pavletic, Stephanie Lee, Maria Blasi, Alessandra Tiberti, Paola Valente, Michela Laguardia, Maria Sammarco, Angelo Balestrazzi, Luigi Larocca, Emilio Balestrazzi, Ahmad Otri, Usama Fares, Mouhamed Al-Aqaba, Harminder Dua, Andrea Leonardi, Daniela Lazzarini, Massimo Bortolotti, Federico Piliego, Edoardo Midena, Iva Fregona, Kevin Kalwerisky, Brett Davies, Lisa Mihora, Craig Czyz, Jill Do, Sheri Foster
Journal: Ophthalmology (2012)
THE CALIFORNIA FUND.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Brexanolone (Zulresso) for Postpartum Depression
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ocular integrity after refractive procedures: Author’s reply
Authors: Lester W Peacock
Journal: Ophthalmology (1998)

Dr. Casebeer has inquired about the method of radial keratotomy performed on our donor eyes. As stated in the Materials and Methods section of the paper, we used a modified Lindstrom mini-RK nomogram and performed a limbal-sparing technique as described for this nomogram. Limbal-sparing techniques were preferred at the time of the study as a result of prior similar articles which revealed that limbal-sparing techniques preserve the integrity of the globe much better than those that involve the limbus. We apologize for any confusion on this point.
Final results of phase I and pharmacokinetic trial of SJG-136 administered on a daily x 3 schedule
Authors: I. Puzanov, W. Lee, J. D. Berlin, M. W. Calcutt, D. L. Hachey, W. L. Vermeulen, V. J. Spanswick, J. A. Hartley, A. P. Chen, M. L. Rothenberg
Journal: Journal of Clinical Oncology (2008)

2504 Background: SJG-136 is a pyrrolobenzodiazepine dimer that forms DNA crosslinks and has demonstrated a broad antitumor activity. Daily x 5 schedule led to edema and delayed liver toxicity (AACR/EORTC/NCI 2006). We report results of a daily x 3 schedule with dexamethasone premedication (dex) and diuretic support. Methods: Pts with refractory solid tumors received SJG-136 IV daily x 3, every 21 days, starting dose 20 μg/m2/day and 3+3 design with fixed-dose increments. Pts received dex on D -1 to 3 of each cycle and followed a diuresis protocol with spironolactone (S). Pharmacokinetics was assessed on Days 1 and 3 of Cycle 1 and 2 using a sensitive HPLC/MS/MS assay. Single cell gel electrophoresis (comet) was used to detect DNA crosslinks in PBMCs. Results: 14 pts (8M, 6F) were enrolled. Median age: 55 (range: 41–81), median PS: 1 (0–1), median # of prior regimens: 3 (1–5). Dose levels tested (μg/m2/day): 20 (3 pt), 25 (3 pt), 30 (6 pts), 35 (2 pts). DLT/Toxicity: DLT was Gr 3 soft tissue edema, dyspnea, fatigue in one and Gr 3 transaminitis in the second pt at the 35 μg/m2/day. Gr 1 edema occurred during Cycles 2–4 in 4 additional pts treated at the 30 μg/m2/day dose level. This was manageable with diuretics without need for dose interruption. Other toxicities: hypophosphatemia, hypoalbuminemia, myalgias. No significant myelosuppression was observed. MTD/RPTD: 30 μg/m2/day daily x 3 q 21 days. Pharmacokinetics: The PK analysis revealed dose-dependent increases in AUC and Cmax on Day 1 of Cycle 1. In some patients, repeated SJG-136 dosing appeared to induce substantial changes in the PK parameters of SJG-136, in particular, volume of distribution (Vss). Pharmacodynamics: DNA crosslinks were detectable in PBMCs on D3. Responses: 2 PR (ovarian CA, poorly dif. CA) by RECIST. 1 pt with SD for 4.5 months (leiomyosarcoma), 2 pts with SD (SCLC, bladder) > 3 months. Conclusions: The RPTD of SJG-136 administered on a daily x 3 basis is 30 μg/m2/day. At this dose 2 out of 6 pts achieved PR. The premedication with dex and S diuresis can successfully manage the delayed hepatotoxicity and soft tissue edema. Day 3 increase in Vss may correlate with subsequent development of significant soft tissue edema. DNA crosslinks were detectable in PBMCs on Day 3. Supported by NIH U01 CA099177, M01 RR00095 and CRUK C2259/A3083. No significant financial relationships to disclose.
Incidence and prognostic significance of extramural venous invasion in T3-4 esophageal cancer.
Authors: Zohra Faiz, Lotte Huijgen, Hanadi Alqethami, Gursah Kats-Ugurlu, John Theodorus Plukker
Journal: Journal of Clinical Oncology (2017)

44 Background: Extra mural venous invasion (EMVI) is known as an adverse prognostic indicator of survival and an important predictor of systemic recurrences in colorectal carcinoma. However, the incidence and significance of EMVI in esophageal cancer (EC) have not been studied well. Aim: To estimate the incidence and the prognostic significance of EMVI in pathological stage T3-4 EC resection specimens without neoadjuvant chemoradiotherapy (nCRT) Methods: From a prospective maintained database we retrospectively review the resected specimens of patients with an EC. For adequate EMVI assessment we only included patients without nCRT and excluded patients without previous malignancies and patients with cardia/gastroesophageal junction tumors. A total of 76 patients were included between 2000 and 2012. EMVI was assessed on haematoxylin and eosin slides and for confirmation additional Elastica van Gieson staining was performed. Disease free survival was analyzed using a multivariable logistic regression and Kaplan-Meier method. Results: Evidence of EMVI was found in 18 patients (23.7%). The incidence of EMVI was significantly higher in squamous cell carcinomas (p &lt; 0.05) and among tumors located in the mid-esophagus (p &lt; 0.05). In the univariate analysis, pathological N- stage (HR 3.6 95%Cl: 1.5-8.5; p = 0.004) and positive circumferential resection margin (CRM) (HR 2.3 95% Cl: 1.2-4.5 p = 0.015) were independent prognostic factors. By stepwise multivariate Cox regression analysis, pathological tumor length (HR 2.5 95%Cl: 1.0-6.5 p = 0.05), pathological N- stage (HR 2.7 95%Cl: 1.3-6.2 p = 0.008), positive CRM (HR 2.3 95% Cl: 1.2-4.5 p = 0.009) and EMVI (HR 2.2 95% Cl: 1.0-4.5 p = 0.04) were shown to be independent prognostic factors for disease free survival. Conclusions: A search for EMVI may provide additional prognostic information in esophageal cancer, especially in squamous cell carcinoma.
Bacterial Meningitis — A Review of Selected Aspects
Authors: Morton N. Swartz, Philip R. Dodge
Journal: New England Journal of Medicine (1965)

Special Features Recurrent bacterial meningitis. Repeated episodes of bacterial meningitis represent a clinical entity limited almost exclusively to the antibiotic era. Such a clinical problem introduces the following important considerations: gross anatomic defects, congenital or acquired, of the central nervous system and its coverings; parameningeal foci of infection; and impaired antibacterial or immune responses.During the years encompassed by this review 6 cases of recurrent bacterial meningitis were encountered. All could be related to an anatomic defect, most often of traumatic origin. Although a parameningeal focus of infection (sinus or mastoid) was implicated many times, and brain abscess once, as . . .
Pellagra.
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Smoking cessation and decreased risk of stroke in women
Authors: I. Kawachi
Journal: JAMA (1993)

<h3>Objective.</h3> —To prospectively examine the relationship of time since stopping smoking with risk of stroke in middle-aged women. <h3>Design.</h3> —An ongoing prospective cohort of women with 12 years' follow-up data (1976 to 1988), in which information on smoking habits was updated every 2 years by postal questionnaire. <h3>Population Studied.</h3> —A total of 117 006 female registered nurses aged 30 to 55 years in 1976 and free of coronary heart disease, stroke, and cancer at baseline. <h3>Main Outcome Measures.</h3> —Incident strokes (fatal and nonfatal), further subdivided into ischemic stroke, subarachnoid hemorrhage, and cerebral hemorrhage. <h3>Results.</h3> —The age-adjusted relative risk of total stroke among current smokers compared with never smokers was 2.58 (95% confidence interval, 2.08 to 3.19). The corresponding relative risk among former smokers was 1.34 (95% confidence interval, 1.04 to 1.73). For total and ischemic stroke, the excess risks among former smokers largely disappeared from 2 to 4 years after cessation. The same patterns of decline were observed regardless of number of cigarettes smoked, the age at starting, or the presence of other risk factors for stroke. <h3>Conclusions.</h3> —The risk of suffering a stroke among cigarette smokers declines soon after cessation and the benefits are independent of the age at starting and the number of cigarettes smoked per day. (<i>JAMA</i>. 1993;269:232-236)
1999 Albert Lasker Medical Research Awards Presented
Authors: M. F. Goldsmith
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
RELATIONS OF PHARMACY TO THE MEDICAL PROFESSION.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Development of a comprehensive supportive care team for the hopelessly ill on a university hospital medical service
Authors: R. W. Carlson
Journal: JAMA (1988)

We developed a supportive care service for a university hospital medical service that serves a socially and medically disadvantaged urban population. The team includes a faculty physician and a clinical nurse specialist who provide primary medical care, family support, and in-service guidance to hospital staff about ethical issues. A multidisciplinary approach incorporates nursing, pastoral care, social work, and other hospital services. We report our experience from November 1985 through May 1987, during which time 222 patients were referred to the team; 212 patients were accepted. The goals and operation of the service are described. The most common (n=62, 29%) diagnosis on referral was global central nervous system anoxia following cardiopulmonary arrest. Other severe neurological conditions accounted for an additional 79 patients (37%). Comparison of patients on the service with a similar group revealed no difference in survival rate, although hospital length of stay and charges were progressively reduced after implementation of the service. This approach to the care of hopelessly ill patients may serve as an alternative method of treatment in similar hospital settings. (<i>JAMA</i>1988;259:378-383)
Subcutaneous injection of metallic mercury
Authors: I. T. Krohn
Journal: JAMA (1980)

METALLIC mercury poisoning is unusual. Oral intake of metallic mercury is usually of no consequence to the patient's health. However, subcutaneous or intravenous injection of mercury poses a definite health hazard. We present a case of intentional self-injection of metallic mercury; systemic mercury absorption was monitored by laboratory determinations of mercury concentrations in serum and urine. <h3>Report of a Case</h3> A 13-year-old boy, who had a history of destructive and attention-getting behavior, drank a tablespoonful of metallic mercury nine days before hospital admission "to see what would happen." There was no apparent reaction, and two days before admission, he injected metallic mercury subcutaneously in six different sites using one of his mother's insulin syringes. He estimated that he had injected 0.1 mL into each site, which became painful. At the time of admission, there were two small, nonfluctuant, tender masses on the left forearm, two on the dorsum of the
ANEMIA IN PORTO RICO.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Personal View
Authors: J. Rawles
Journal: BMJ (1987)

<h3>Abstract</h3> A DNA double strand break (DSB) is primed for homologous recombination (HR) repair through the nucleolytic processing (resection) of its ends, leading to the formation of a 3′ single-stranded DNA (ssDNA). Generation of the ssDNA is accompanied by the loading of several repair factors, including the ssDNA binding factor RPA and the recombinase Rad51. Then, depending upon the availability and location of a homologous sequence, different types of HR mechanisms can occur. Inefficient or slow HR repair results in the activation of the DNA damage checkpoint (DDC)<sup>1</sup>. In budding yeast, the 53BP1 ortholog Rad9 acts as a scaffold, mediating signal from upstream kinases Mec1 and Tel1 (ATR and ATM in human) to downstream effectors kinases Rad53 and Chk1 (CHK2 and CHK1 in human). In addition to its role in DDC, Rad9 limits DSB resection <sup>2</sup>. Remarkably, this function is conserved in 53BP1, also being implicated in cancer biology in human cells <sup>3,4</sup>. Here we show that Rad9 limits the recruitment of the helicases Sgs1 and Mph1 on to a DSB, promoting Rad51-dependent recombination with long track DNA conversions, crossovers and break-induced replication (BIR). This regulation couples the DDC with the choice and effectiveness of HR sub-pathways, and might be critical to limit genome instability with implication for cancer research.
An Aid to Materia Medica.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Endobronchial nocardial infection.
Authors: K D McNeil, D W Johnson, W A Oliver
Journal: Thorax (1993)

The rare presentation of nocardial infection as an endobronchial "tumour" is reported. Haematogenous dissemination occurred after fibreoptic bronchoscopy and biopsy, a phenomenon not previously described in nocardial infections. This case highlights the difficulties in diagnosing pulmonary nocardial infection and the potential for invasive procedures to disseminate the disease.