tbuckley/cabot-search huggingface dataset:
The algorithm in medicine
Authors: L. B. Sheiner
Journal: JAMA (1978)

Sheiner et al write as though my intention had been to patch up their algorithm. It was not. It was to warn against taking seriously "one person's concept of how to play a game." My questions were not intended to imply that routine reticulocyte counts or routine serum iron measurements should be forced on physicians on pain of being zapped by score-keeping clinical pathologists. I intended that they illustrate how unrealistic some of the procrustean requirements appear on paper. Ordering serum folate and B<sub>12</sub>determinations in every case of macrocytic anemia with a normal reticulocyte count seems analogous to prescribing folate and B<sub>12</sub>determinations for every patient with macrocytic anemia. We should discourage such practices, not give praise. The authors' reiteration of procedures and intentions changes nothing, even though their three cases of missed iron deficiency anemia became two on retelling, and even though they say
Update: Influenza Activity—United States and Worldwide, 1995-96 Season, and Composition of the 1996-97 Influenza Vaccine
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PUBLIC HEALTH.
Authors: W. K. Curtis
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE BACILLUS DYSENTERIÆ.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
EXTH-51. ANTI-INVASIVE EFFICACY AND SURVIVAL BENEFIT OF THE YAP-TEAD INHIBITOR VERTEPORFIN IN PRECLINICAL GLIOBLASTOMA MODELS
Authors: Anne Marie Barrette, Alexandros Bouras, German Nudelman, Zarmeen Mussa, Elena Zaslavsky, Constantinos Hadjipanayis, Marc Birtwistle, Nadejda Tsankova
Journal: Neuro-Oncology (2020)

Abstract Glioblastoma (GBM) remains an incurable disease, in large part due to its malignant infiltrative spread, and current clinical therapy fails to target the invasive nature of tumor cells in disease progression and recurrence. Here, we use the YAP-TEAD inhibitor Verteporfin to target a convergence point for regulating tumor invasion/metastasis and establish the robust anti-invasive therapeutic efficacy of this FDA-approved drug and its survival benefit across several preclinical glioma models. Using patient-derived GBM cells and orthotopic xenograft models (PDX), we show that Verteporfin treatment disrupts YAP/TAZ-TEAD activity and processes related to cell adhesion, migration and epithelial-mesenchymal transition. In-vitro, Verteporfin impairs tumor migration, invasion and motility dynamics. In-vivo, intraperitoneal administration of Verteporfin in mice with orthotopic PDX tumors shows consistent drug accumulation within the brain and decreased infiltrative tumor burden, across three independent experiments. Interestingly, PDX tumors with impaired invasion after Verteporfin treatment downregulate CDH2 and ITGB1 adhesion protein levels within the tumor microenvironment. Finally, Verteporfin treatment confers survival benefit in two independent PDX models: as monotherapy in de-novo GBM and in combination with standard-of-care chemoradiation in recurrent GBM. These findings indicate potential therapeutic value of this FDA-approved drug if repurposed for GBM patients.
Lectures on the Experimental Investigation of the Action of Medicines
Authors: T. L. Brunton
Journal: BMJ (1871)

AMethod of Rejresenting Experiments.APPLICATION TO PATHOLOGY.-Thebrief sketch of the circulation which I have given, will enable you to understand and appreciate the meaning of the changes produced in our circulation by any drug, and to explain the facts we may meet with in the course of an investigation.I may remind you that the alterations in the pulse-rate and blood-pressure which we meet with in disease, as well as those produced by drugs, are due to some one or other of the causes mentioned in the previous table; and whenever you meet with a quick, slow, weak, or irregular pulse, you must try to find out to which of these causes it is due, in order that you may be able to apply scientifically the proper remedy.
Amer J of Roentgenology, Springfield, Ill
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cell Adhesion Induces p27Kip1-Associated Cell-Cycle Arrest through Down-Regulating SCFSkp2 Ubiquitin Ligase Pathway in Mantle Cell and Other Non-Hodgkin’s B-Cell Lymphomas.
Authors: Tint Lwin, Lori A. Hazlehurst, Lynn C. Moscinski, William S. Dalton, Jianguo Tao
Journal: Blood (2006)
Treatment of severe aplastic anemia with an immunosuppressive agent plus recombinant human granulocyte‐macrophage colony‐stimulating factor and erythropoietin
Authors: Zonghong Shao, Yulin Chu, Yizhi Zhang, Guibin Chen, Yizhou Zheng
Journal: American Journal of Hematology (1998)

To evaluate the therapeutic potential of hematopoietic growth factors (HGFs) during immunosuppressive treatment (IST) of severe aplastic anemia (SAA), 38 patients with newly diagnosed SAA received IST alone (group I), or IST plus recombinant human erythropoietin and granulocyte-macrophage colony-stimulating factor (rhEPO + rhGM-CSF) (group II). Eleven patients in each group received antilymphocyte globulin (ALG) for IST, and eight patients in each group received cyclosporine (CSA). Complete remission rates at one year were 26% and 74% for group I and group II patients, respectively. The ALG-treated subgroup showed the greatest differences between treatments. Compared with patients receiving ALG alone, patients treated with ALG plus HGFs had significantly better one-year survival (100% vs. 54.5%, P < 0.05), complete remission rates (91% vs. 36%, P < 0.05), more rapid and complete hematologic recovery, greater reductions in transfusion requirements, and lower infection rates. The data suggest a potential role for rhEPO + rhGM-CSF therapy in SAA patients receiving IST. Am. J. Hematol. 59:185–191, 1998. © 1998 Wiley-Liss, Inc.
The involuting hemangioma
Authors: F. A. Kingery
Journal: JAMA (1965)

The involuting hemangioma, or strawberry birthmark, is small or absent at the time of birth. During the first six or eight months of life it increases rapidly in size, and then gradually regresses over the next one to five years. In the uncomplicated lesion the best eventual result is achieved with no treatment at all. Observation alone is not possible, however, when the tumor is so situated that it interferes with the visual axis, or disturbs such vital functions as breathing or sucking. Active treatment in the form of ionizing radiation, cryotherapy, or surgical removal is sometimes necessary to preserve these functions. The tumor should not be confused with a cavernous hemangioma, which is present at birth and grows slowly as the child grows. Composed of mature endothelial cells, the cavernous hemangioma is radiation resistant, unaffected by cryotherapy, and shows no tendency toward spontaneous involution. Difficulty arises when the parents
Hospital Medication Errors
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The paradigm of the two faced Janus: NAFLD and cardiovascular disease. An integrated and multidisciplinary new model to approach outpatients affected by diabetes type 2 and NAFLD
Authors: Diego Caroli, Erik Rosa-Rizzotto, Laura Scribano, Laura Peraro, Salvatore Lobello, Maria Grazia Dal Frà, Annunziata Lapolla, Franca De Lazzari
Journal: Journal of Hepatology (2020)
Stopping postop shivers eases rewarming
Authors: E. R. Gonzalez
Journal: JAMA (1982)

Although shivering generally is an important adaptive response to cold, it "may not be the optimal method of rewarming in the postoperative period," reported anesthesiologist Jorge L. Rodriguez, MD, at the recent American College of Surgeons meeting in Chicago. This is particularly true with respect to patients with preexisting cardiopulmonary disease who have been chilled during any type of major surgery, he said. In these patients, the least physiologically debilitating approach to rewarming may be complete obliteration of normal shivering. Rodriguez reported on a study of 16 such patients who underwent major surgery at Columbia Presbyterian Hospital, New York City, and were subsequently admitted to the Surgical Intensive Care Unit, where they were maintained on mechanical ventilatory support for 24 hours. All of the patients were hypothermic, with esophageal temperatures of less than 35.8 °C, after having major body cavities exposed to a cool operating room and being unable to
Risk of lung cancer according to histologic type and cigarette dosage
Authors: W. Weiss
Journal: JAMA (1972)

The risk of developing various histologic types of bronchogenic carcinoma was determined in a ten-year prospective study of 6,136 older men in relation to smoking habits at the beginning of observation. No lung cancer developed in 830 nonsmokers. Among the 2,580 men who regularly smoked cigarettes only and who were current smokers on entry, the risk of lung cancer increased with increasing daily cigarette consumption. The cancers were typed according to a modification of the World Health Organization classification. Well-differentiated squamous-cell carcinoma, small-cell carcinoma, and adenocarcinoma showed a dose-response relationship to cigarette smoking, but poorly differentiated squamous-cell carcinoma did not.
Thrombocytopenia following doxepin treatment
Authors: D. D. Nixon
Journal: JAMA (1972)

<h3>To the Editor.—</h3> Proof of an adverse drug reaction usually depends upon circumstantial "post hoc propter hoc" evidence. Recently a patient was seen who developed thrombocytopenia following exposure to doxepin hydrochloride. Subsequent exposure to amitriptyline hydrochloride, a structurally related compound, was followed by a severe fall in platelet count, suggesting an etiological relationship. <h3>Report of a Case.—</h3> A 73-year-old housewife was admitted to Miami Heart Institute because of a severe depressive reaction and mild essential hypertension, treated with spironolactone, chlorothiazide, and reserpine for many years. Desiccated thyroid had been taken for 20 years following removal of a goiter. Four days prior to admission, doxepin hydrochloride was prescribed for relief of her depressive reaction. On the second hospital day, she developed subconjunctival hemorrhages, generalized oozing from the mouth, and showers of petechia over the extremities and trunk. The blood pressure 160/100 mm Hg. There was no significant adenopathy. Laboratory data at
Vitamin B15—whatever it is, it won't help
Journal: JAMA (1980)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bacterial Shock
Authors: Nelson R. Zide
Journal: JAMA (1976)

<h3>To the Editor.—</h3> The article by Shubin and Weil (235:421,1976) is a good general review; however, I believe that there are a couple of critical points that need reevaluation and reemphasis. The authors suggest that prior to initiation of antibiotic therapy, blood cultures are necessary and should be taken from a single venipuncture. I wish to point out that obtaining blood cultures in this situation certainly is imperative, however, most experts in the field of infectious diseases would agree that three venipunctures from a single site are probably of no greater value than one single blood culture. It is generally accepted that the timing of blood cultures in this circumstance is not necessarily critical, and indeed, all cultures may be taken a few minutes apart. With the possible exception of the neonate, these cultures should be taken from separate venipunctures.<sup>1-3</sup> In the discussion of therapy for bacteremic shock, I
641TiP Phase Ib/II trial of pembrolizumab (pembro) + vibostolimab combination therapy in patients (Pts) with adenocarcinoma metastatic castration-resistant prostate cancer (mCRPC) or treatment-emergent neuroendocrine mCRPC (t-NE): KEYNOTE-365 cohorts G and H
Authors: J.S. de Bono, N.D. Shore, G. Kramer, A.M. Joshua, X.T. Li, C.H. Poehlein, C. Schloss, E.Y. Yu
Journal: Annals of Oncology (2021)
Long-term effects of dieting on resting metabolic rate in obese outpatients
Authors: T. A. Wadden
Journal: JAMA (1990)

There is growing concern that dieting may adversely affect the metabolic rate and exacerbate efforts to control weight. In this study we measured the resting metabolic rate nine times over 48 weeks in 18 obese women (108.0 ± 3.1 kg) who were randomly assigned to one of two dietary conditions. Nine patients consumed approximately 5021 kJ/d (1200 kcal/d) throughout the 48 weeks, while the other nine consumed a 1757-kJ/d (420-kcal/d) diet for 16 of the first 17 weeks and a conventional reducing diet for the remainder of treatment. All patients increased their physical activity, primarily by walking. During the first 5 weeks, the fall in metabolic rate was more than double the relative reduction in weight. By contrast, at week 48, the metabolic rate of patients in the two conditions was reduced by 9.4% ±4.0% and 8.3% ±2.2%, respectively, while weight was reduced by 16.6% ±2.7% and 19.5%±2.7%, respectively. Thus, neither dietary regimen, combined with modest physical activity, was associated with long-term reductions in resting metabolic rate that exceeded decreases anticipated with the achievement of a lower body weight. (<i>JAMA</i>. 1990;264:707-711)
CORRELATION OF BIOLOGIC REACTIONS IN HEALTH AND IN DISEASE
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
'Medical Care for All': Questions and Answers
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pregnancy in a patient with a prosthetic mitral valve. Associated with a fetal anomaly attributed to warfarin sodium
Authors: I. J. Kerber
Journal: JAMA (1968)

Pregnancy in a patient with a prosthetic mitral valve was carried to term without any overt evidence of medical complications. The infant was born with hypoplastic nasal structures. Warfarin (Coumadin) sodium is suspected as the teratogenic agent.