tbuckley/cabot-search huggingface dataset:
The course of galactose elimination capacity in patients with alcoholic cirrhosis: Possible use as a surrogate marker for death
Authors: C Merkel, G Marchesini, A Fabbri, S Bianco, G Bianchi, E Enzo, D Sacerdoti, M Zoli, A Gatta
Journal: Hepatology (1996)

There is increasing interest for the use of surrogate end points in the evaluation of treatments in patients with liver disease, but adequate validation is seldom available. This study aimed to describe the different course of galactose elimination capacity in patients with alcoholic cirrhosis who continued to drink or abstained from alcohol consumption during follow–up, and to validate changes in galactose elimination as a surrogate end point for death from liver–related causes. Forty–five patients with alcoholic cirrhosis (22 who continued drinking throughout the study period, and 23 who stopped drinking and were abstinent throughout the study period) were retrospectively selected among patients who had galactose elimination capacity measured at 6–month intervals. During follow–up 10 drinkers and 3 abstainers died of liver–related causes ( P = .025). Abstainers showed a transient improvement in galactose elimination capacity, followed by a decrease. Continuous drinkers showed a reduction from the beginning. According to Cox's regression analyses, persistent alcohol abuse and galactose elimination capacity were separately related to the risk of death, but, when a time–dependent model was fitted containing galactose elimination capacity and persistent alcohol abuse, only the former remained significant. This implies that variations in the risk of death occurring as a consequence of abstinence from alcohol consumption may be predicted from changes in galactose elimination capacity, and that the mechanisms through which abstinence influences survival are strictly linked to the mechanisms responsible for the changes in the test. Because of the strict association of decrease in galactose elimination capacity and short survival, as proved in several series, this observation represents adherence to the criteria requested for adequacy of a surrogate end point. In conclusion, in alcoholic cirrhosis the decrease in galactose elimination capacity is an adequate surrogate end point for death from liver–related causes, which is worth testing in other conditions and in response to other treatments.
MR. HULL AND THE ARMY MEDICAL BILL.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
EPILEPSY AND RESPONSIBILITY.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fault
Authors: Gordon D Rubenfeld
Journal: Annals of Internal Medicine (2009)

On Being a Doctor16 June 2009FaultGordon D. Rubenfeld, MDGordon D. Rubenfeld, MDFrom University of Toronto, Toronto, Ontario M4N 3M5 Canada.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-150-12-200906160-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Crude tattoos of “LOVE” and “HATE” unfurled as the angry, muscular man clenched and unclenched his fists. I am not a small man, but this guy was scaring me.“How the hell do you let my boy lay there for 4 days before you even call me?”“Mmm-hmm,” echoed the large woman at his side who had introduced herself as the boy's mother. In her shadow was a nervous girl who had been crying or screaming a lot. She fidgeted and picked at invisible things on her blouse—I wondered briefly what she was withdrawing from.Behind them were at least ... Author, Article, and Disclosure InformationAffiliations: From University of Toronto, Toronto, Ontario M4N 3M5 Canada.Note: The names and some details have been changed to protect the anonymity of the participants.Corresponding Author: Gordon D. Rubenfeld, MD, University of Toronto, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Room D503, Toronto, Ontario M4N 3M5, Canada; e-mail, gordon.[email protected]ca. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 16 June 2009Volume 150, Issue 12Page: 887-888KeywordsBloodBrainCardiopulmonary resuscitationChartsCocaineHeartIntensive care unitsNursesVentilatorsVentricular fibrillation ePublished: 16 June 2009 Issue Published: 16 June 2009 Copyright & PermissionsCopyright © 2009 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Youthful Recollections
Authors: John Brett Langstaff
Journal: JAMA (1969)

To think of Sir William Osler is, for me, to recall England and America at their best. Others are better qualified to pay tribute to him as a great teacher and trailblazer of the medical profession whose vision opened the way into a new world of modern medicine. To me, however, was given the privilege of an intimate friendship during the latter years of Sir William's life. His magnetic optimism, humor, and generosity—which led many of his contemporaries into effective enterprises for public health and individual well-being—was to be an inspiration for me in another field of endeavor. Among the many British physicians who esteemed Sir William Osier was the Vice-Chancellor of London University, Philip Henry Pye-Smith, who died in 1914. In that year Dr. Pye-Smith's son—we were undergraduates together at Magdalen College, Oxford—took me to 13, Norham Gardens and introduced me to his late father's friend. Then something uncanny
LET'S CUT WASTE FROM INTERNSHIPS AND RESIDENCIES
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
JAMA 75 YEARS AGO
Journal: JAMA (1979)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ethical issues in health care system reform. The provision of adequate health care. Council on Ethical and Judicial Affairs, American Medical Association
Journal: JAMA (1994)

AS AMERICAN Medical Association (AMA) policy states, society should afford every citizen access to adequate health care: "The patient has a basic right to have available adequate health care."<sup>1</sup>In this report, the Council discusses the ethical foundations of society's obligation to ensure that none of its members is denied access to adequate health care because of an inability to pay for it. This obligation rests primarily on the belief that a just society affords its members reasonable protection from illness and disability to ensure that they have a fair opportunity to pursue their goals in life.<sup>2,3</sup> The Council also discusses the definition of "adequate health care" in this report, because determining an adequate level of health care is an essential step in guaranteeing meaningful universal access. The Council believes that the definition should follow sound ethical principles and fair procedures and take the form of a basic
Determinants of favorable outcome following extracorporeal membrane oxygenation for cardiac failure in 128 adults: A single center experience Ko Bando, Yoshikado Sasako, Shunichi Miyazaki, Junjiro Kobayashi, Hiroaki Konishi, Toshihiko Sato, Takeshi Aiba, Kazuo Niwaya, Toshikatsu Yagihara, Osamu Tagusari, Soichiro Kitamura. National Cardiovascular Center, Osaka, Japan
Journal: Journal of the American College of Cardiology (2001)
Part 1: Introduction
Authors: This document presents international consensus statements on the science of resuscitation and, wherever possible, treatment recommendations. ILCOR member organizations will subsequently publish resuscitation guidelines that are consistent with the science in this consensus document, but they will also take into account geographic, economic, and system differences in practice and the availability of medical devices and drugs. All ILCOR member organizations strive to minimize international differences in resuscitation practice and to optimize the effectiveness of instructional methods, teaching aids, and training networks.
Journal: Circulation (2005)
HmPg Doctor
Authors: Saty Satya Murti
Journal: JAMA (1996)

The URL for the page created for this review is: http://ourworld.compuserve.com/homepages/gno/. The interface between medicine and the Internet is still in the formative stages. Therefore, I wish to review this software in two parts, the HmPg Doctor program first, and, next, the trend toward establishing home pages on the World Wide Web. The program: HmPg Doctor is a CD-ROM. It provides a framework for creating and launching a physician's Web page on the Internet. The program installed easily from my CD drive and created a Windows 95 icon. It provided very convenient templates for text entry. There are eight index tabs under which I may key in the message that I wish to broadcast to the Web world. After a personal introduction, I announce my office hours and "new" messages, if any. The program allows me to receive e-mail also, from my readers. Next, I may create a discussion
Pansies
Authors: M. Therese Southgate
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE PSEUDO-DIPHTHERITIC BACILLUS.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
NEUROSURGERY
Authors: C. Charalampaki, C. Eyth, M. Morgan, C. Charalampaki, C. Eyth, M. Morgan, C. Charalampaki, C. Eyth, M. Morgan, H. Ogiwara, C. Kiyotani, K. Terashima, N. Morota, C. Charalampaki, A. Igressa, A. Igressa, C. Charalampaki, B. Pettorini, B. Pizer, A. Kanwar, S. Avula, C. Mallucci, H.-A. Leroy, M. Baroncini, I. Delestret, M. Vinchon, T. Kato, T. Hankinson, R. Dudley, S. Poonia, M. Torok, M. Handler, A. Liu, D. Harter, M. Karajanis, J. Wisoff, H. Weiner, I. Toidze, V. Tsikarishvili, N. Lobjanidze, I. Elizbarashvili, N. Akiashvili, T. Maisuradze, A. Jaiswal, S. Jaiswal, A. Mehrotra, A. Srivastava, R. Sahu, S. Behari, S. Jaiswal, A. Jaiswal, A. Mehrotra, S. Behari;, T. Hankinson, D. Curry, J. Honeycutt, B. O'Neill, M. Handler, T. George, N. U. Gerber, A. Muller, O. Bozinov, C. Berger, M. A. Grotzer, I. Kamaly-Asl, R. Alston, M. McCabe, J. Birch, R. Gattamaneni, E. Estlin, G. Coelho, F. Kunsler, L. Lessa, S. Epelman, N. Zanon
Journal: Neuro-Oncology (2014)
Ultrasound examination of the gallbladder. An alternative to "double-dose" oral cholecystography
Authors: R. J. Bartrum
Journal: JAMA (1976)

THE LONG-APPRECIATED problem of poor gallbladder visualization following a single dose of an orally administered contrast agent continues to stimulate controversy. None of the various orally administered agents consistently gives satisfactory opacification with standard dosage. Nearly everyone agrees that the traditional remedy of a "double dose" (actually a repeat single dose) is costly in both physician and patient time, as well as in increased radiation exposure. Some physicians advocate using a "double dose" initially.<sup>1,2</sup>Others believe that this is wasteful, because it subjects the majority of patients to unnecessary overdosage, and prefer diet modifications, oral cholecystogogues, or bile salts.<sup>3</sup> We believe that ultrasonic examination of the initially nonvisualized gallbladder is superior to any of these suggestions. <h3>Materials and Methods</h3> Fifty patients with a nonvisualized gallbladder following a single 3-gm dose of tyropanoate sodium (Bilopaque) were examined with a commercially available bistable B-scanner and a 2.25-MHz transducer. The ultrasound
Diabetic Retinopathy
Authors: Med H.-G. Grigoleit
Journal: JAMA (1976)

<h3>To the Editor.—</h3> I refer to the editorial by Dr Vaisrub(233:1303, 1975) where several intravascular factors in diabetic retinopathy are enumerated. Hemorrheological research within the last decade disclosed that additional factors have to be taken into consideration. It seems that disturbed flow properties of whole blood and plasma play a role in the development of diabetic retinopathy or microangiopathy, respectively. More than 30 articles cite an increase in whole blood or plasma viscosity in diabetics. This increase is caused by factors mentioned in the editorial (fibrinogen, α<sub>2</sub>-macroglobulin), but additional changes in blood constituents as β-globulins,<sup>1</sup>hemoconcentration,<sup>2</sup>pH changes,<sup>3,4</sup>and changes in plasma osmolarity in diabetic coma (influence on red blood cell deformability) have to be considered. Microrheological changes in the blood of diabetics might be responsible for the development of diabetic microangiopathy, since these alterations act mainly in the microcirculation. Furthermore, recent research has shown
Michael B. Gregg, M.D., In Honor of 21 Years' Service as Editor, MMWR
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Question of risk still hovers over routine prenatal use of ultrasound
Authors: B. Bolsen
Journal: JAMA (1982)

In the past ten years, ultrasound has developed from a research instrument into a valuable and widely used diagnostic tool in the practice of obstetrics. Its ability to "see" inside the womb, its noninvasiveness, and its apparent safety have led a growing number of obstetricians to advocate its routine use in prenatal care. But at a recent symposium concerning the effects of ultrasound on the fetus, research scientists and clinicians shied away from such a recommendation, citing their inability to quantify the risk. Until physicians can say with assurance that ultrasound does not produce subtle or delayed harmful effects, it should be used only when medically indicated, most of the participants agreed. The meeting, sponsored by the March of Dimes Birth Defects Foundation and Columbia University College of Physicians and Surgeons in New York, included a discussion of recent in vitro, in vivo, and epidemiological investigations and their implications for
Accidental Hypothermia
Authors: Daniel F. Danzl, Robert S. Pozos
Journal: New England Journal of Medicine (1994)

Accidental hypothermia is defined as an unintentional decline in the core temperature below 35 °C. At this temperature, the coordinated systems responsible for thermoregulation begin to fail, since the compensatory physiologic responses to minimize heat loss through radiation, conduction, convection, respiration, and evaporation are very limited.14 In this article, we shall present an overview of the pertinent pathophysiology and guidelines for resuscitation and rewarming.Nuclei in the preoptic anterior hypothalamus coordinate heat conservation. Activation of these thermostats and the cutaneous cold receptors initiates a cascade of compensatory physiologic events (Table 1). After the initial stimulus, there is progressive depression . . .
Emergency Surgery: The Military Surgery of the World War Adapted to Civil Life.
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal