tbuckley/cabot-search huggingface dataset:
Pediatrics
Authors: L. A. Barness
Journal: JAMA (1992)

Excitement and enthusiasm accompany the discovery of a rapid economical way to diagnose the most common form of inherited mental retardation, the fragile X syndrome. Fragile X, a cytogenetic abnormality in the X chromosome, previously detected by the manipulation of the folate content of the cell culture medium, occurs in one of every 1000 mentally retarded boys and in one of every 2000 girls. The physical signs in boys with the syndrome include moderate to severe mental retardation, macro-orchidism, large ears, and a long plantar crease between the first and second toes. Other features, including a family history of mental retardation, are also common, but none is diagnostic. Verkerk et al<sup>1</sup>identified the gene, making recognition of this disorder easier than using special cultures of cells and scanning the karyotypes. Rousseau et al<sup>2</sup>and Sutherland et al<sup>3</sup>developed methods for direct diagnosis of the syndrome by DNA
Reply
Authors: Matthew J. Stiller
Journal: Journal of the American Academy of Dermatology (1993)

1 entitled, "Tinea Corporis Gladiatorum: An Epidemic of Trichophyton tonsurans in Student Wrestlers".There have been four reported outbreaks and/or epidemics of tinea corporis in wrestlers in the last three decades, three of the four appearing in the past 6 months. 1 -4 Whether the recent surge in publications on this dermatomycosis represents an actual increased incidence or merely an increased awareness remains to be determined.Cohen and Schmidt 2 suggested the term tinea gladiatarum as analogous to the accepted term herpes gladiatarum S , 6 used to describe outbreaks of herpes simplex virus infection in wrestlers.We dislike the term tinea gladiatorum because it is imprecise and not at all analogous to herpes gladiatorum.Herpes refers to a specific genus.The term tinea is much more vague.There is tinea pedis, tinea manuum, tinea cruris, tinea corporis, tinea unguium, and tinea faciale, each of which can be caused by dermatophytes of several genera.There is also tinea versicolor caused by a lipophilic yeast, not a dermatophyte, and tinea amiantacea,7 describing an asbestos-like pattern of scale on the scalp not induced by a fungus.When one uses the term herpes gladiatarum the genus of the infectious agent and fundamental morphology are immediately communicated.On the other hand, tinea gladiatorum communicates less information.All four epidemics of tinea corporis in wrestlers were caused by dermatophytes of the genus Trichophyton: the Swedish epidemic of 1966 by T. verrucosum 3 and the three 1992 reports by T. tonsurans.!' 2, 4 Certainly, the term trichophytosis gladiatorum more precisely describes these epidemics/outbreaks than the disturbingly imprecise tinea gladiatorum.We suggest that the terms tinea gladiatorum and tinea corporis gladiatorum 2 be eliminated to avoid superfluous synonymy.
ABC of complementary medicine: Herbal medicine
Journal: BMJ (1999)

changes on the basis of nutritional tests provided by commercial companies which advertise laboratory services in the pages of health magazines.Nutritional consultations may be given by a wide range of practitioners with varying levels of training and experience, from complementary practitioners who mainly practise other disciplines through trained nutritional therapists and naturopaths to nurses and doctors who have undertaken further training in nutrition.Nutritional medicine can be a relatively expensive form of complementary medicine.Diagnostic tests can cost from £15 to over £100 per test, nutritional supplements may cost £10-£50 a month, and dietary changes involving organic produce or wholefoods may also have substantial cost implications.
MB-03 * FUNCTIONAL CHARACTERIZATION OF NOVEL BIOMARKERS IN SELECTING FOR SUBTYPE SPECIFIC MEDULLOBLASTOMA PHENOTYPES
Authors: L. Liang, C. Aiken, R. McClelland, L. Morrison, M. Remke, V. Ramaswamy, M. Del Bigio, M. Taylor, T. Werbowetski-Ogilvie
Journal: Neuro-Oncology (2015)
Comparative effects of second-line therapy with obeticholic acid or fibrates in primary biliary cholangitis patients
Authors: Anna Reig, Carmen Álvarez-Navascués, Mercedes Vergara Gómez, Elena Gómez Domińguez, Adolfo Gallego Moya, Indhira Pérez-Medrano, Emilio Fábrega, Manuel Hernández Guerra, Marina Berenguer Haym, Pamela Estevez, Ana Arencibia Almeida, Rosa Morillas, Diana Horta, Agustin Albillos, Marta Casado, Gemma De la Cruz, Eva Fernandez Bonilla, Esther Molina, Lander Hijona, Moises Diago, Conrado Manuel Fernandez Rodriguez, Jesús M. González-Santiago, Margarita Sala, Judith Gómez-Camarero, Manuel Romero Gomez, Francisco Suárez, Vićtor Manuel Vargas Blasco, Carlos Ferre Aracil, Raul J. Andrade, Nadia Chahri, Albert Pares
Journal: Journal of Hepatology (2020)
Limitations of Thrombo-Endarterectomy Described
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Immunologic Aspects of Renal Disease
Authors: John H. Peters, Philip Freedman
Journal: New England Journal of Medicine (1959)

IN discussing disease of the kidney with albuminous urine, Richard Bright1 was moved to remark, "... it may be fairly asserted that no other disease is more interesting in its history and origin, affords so many instances of the consent and dependence of the different functions upon each other, gives so much scope for pathological observations, or is so fertile in facts interesting to the cultivation of animal chemistry, as the disease of which we now speak." Despite the passage of the years, the increase in knowledge and understanding of "Bright's disease" and the growth of an enormous literature on . . .
Efficacy of transjugular intrahepatic porto-systemic shunt in cirrhotic patients with hepatorenal syndrome - chronic kidney disease
Authors: Paola Ponzo, Martina Rizzo, Daniela Campion, Ilaria Giovo, Michele Roma, Felice Rizzi, Alessandra Risso, Gian Paolo Caviglia, Giorgio Maria Saracco, Carlo Alessandria
Journal: Journal of Hepatology (2020)
Gonococcal Infections
Authors: EDWARD W. HOOK
Journal: Annals of Internal Medicine (1985)

Gonorrhea may be the most extensively studied infection of the past 20 years. The gonorrhea epidemic in the United States began in the early 1960s and peaked in 1975. Ironically, since 1976 the declining overall incidence has been offset by the advent of plasmid-mediated beta-lactamase production by Neisseria gonorrhoeae and by a growing problem with outbreaks due to strains with chromosomally mediated penicillin and tetracycline resistance. This new antimicrobial resistance, coupled with the frequency of concurrent chlamydial infection in developed countries and concurrent syphilis in some developing countries, has created a need for new approaches to gonorrhea therapy. With the introduction of certain new antimicrobial agents, highly effective forms of therapy are again available. New approaches to rapid diagnosis are also becoming available, but require critical appraisal. Unfortunately, in most of the world's population, gonorrhea remains epidemic, diagnosis of gonorrhea in women is extremely difficult, and highly effective antimicrobial agents are no longer affordable. Thus, vaccine development remains an extremely important goal. Although no candidate gonococcal vaccine currently holds high promise, the increasing understanding of the biology of the gonococcus and the pathogenesis of gonorrhea will serve to focus future research on vaccine development.
LONDON
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Successful treatment of hepatic coma by exchange transfusions
Authors: M. L. Gelfand
Journal: JAMA (1967)

Hepatic coma developed in a 25-year-old Negro woman with serum hepatitis 24 days after admission. The patient deteriorated and became moribund despite therapy with g'ucose administered intravenously, neomycin sulphate, large doses of steriods, and careful attention to electeolyte balance. Four days later exchange transfusions were begun. She received 5 pt of properly matched blood treated with heparin sodium the first day; 10 pt the second day, and 8 units the third day. Twelve hours after the last exchange, the patient dramatically awoke from her coma and subsequently recovered completely. We believe that exchange transfusions played a significant role in the result obtained and recommend its early use in hepatic coma resulting from fulminating hepatitis.
Satellite dialysis. An economic approach to the delivery of hemodialysis care
Authors: R. T. Bilinsky
Journal: JAMA (1971)

The delivery of hemodialysis care to the population of southern Illinois was extended from the main unit in Springfield by the establishment of several satellite facilities. Utilizing leased space in private medical buildings and small community hospitals, more than 5,000 hemodialyses have been performed during the past 29 months at a cost 50% less than for center dialysis. An increasing patient load has been accepted with ease. Stable patients receiving long-term dialysis are treated in satellite facilities, freeing the main unit to deal more flexibly with acute and complicated dialysis problems. Medical complications in the satellites have been infrequent, and the "back-up" dialysis rate at the main unit is only 4%. Patient acceptance has been excellent due to reduced travel fatigue, savings in travel costs averaging $2,448 per year, and time gained for other activity.
A Randomized Trial of Aspirin and Sulfinpyrazone in Threatened Stroke
Journal: New England Journal of Medicine (1978)

Five hundred and eighty-five patients with threatened stroke were followed in a randomized clinical trial for an average of 26 months to determine whether aspirin or sulfinpyrazone, singly or in combination, influence the subsequent occurrence of continuing transient ischemic attacks, stroke or death. Eighty-five subjects went on to stroke, and 42 died. Aspirin reduced the risk of continuing ischemic attacks, stroke or death by 19 per cent (P less than 0.05) and also reduced risk for the "harder," more important events of stroke or death by 31 percent (P less than 0.05), but this effect was sex-dependent: among men, the risk reduction for stroke or death was 48 per cent (P less than 0.005), whereas no significant trend was observed among women. For sulfinpyrazone, no risk reduction of ischemic attacks was observed, and the 10 per cent risk reduction of stroke or death was not statistically significant. No overall synergism or antagonism was observed between the two drugs. We conclude that aspirin is an efficacious drug for men with threatened stroke.
ACE-536 Increases Hemoglobin and Reduces Transfusion Burden in Patients with Low or Intermediate-1 Risk Myelodysplastic Syndromes (MDS): Preliminary Results from a Phase 2 Study
Authors: Uwe Platzbecker, Ulrich Germing, Aristoteles Giagounidis, Katharina Goetze, Philipp Kiewe, Karin Mayer, Oliver Ottman, Markus P. Radsak, Thomas Wolff, Detlef Haase, Monty Hankin, Dawn M. Wilson, Adberrahmane Laadem, Matthew L. Sherman, Kenneth M. Attie
Journal: Blood (2014)
From<i>JAMA</i>’s Daily News Site
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Consejos Practicos de Higiene Infantil.
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
In This Issue
Journal: Circulation Research (2012)

KLF4 Binds SM22␣ Promoter Via a G/C Repressor Site (p 685)Salmon et al uncover a mechanism in smooth muscle cells that controls the switch from quiescence to proliferation.In walls of blood vessels, smooth muscle cells (SMCs) proliferate only in extreme circumstances.During vessel injury, for example, SMCs increase their numbers to repair the wound, and during atherosclerosis, they contribute to the formation of plaques.Thus, understanding what regulates SMC proliferation could help both with vessel healing and attenuating atherosclerosis.It is known that genes associated with the differentiated SMCs-SMC marker genes-are downregulated when these cells switch from noncycling to a cycling phenotype and that this switch is promoted by the transcription factor KLF4.However, there was no direct evidence that KLF4 actually downregulated the marker genes in questionuntil now.Salmon et al showed that after vascular injury in mice, KLF4 binds to a sequence element upstream of the marker gene SM22␣, recruits other transcription factors, and causes transcriptional suppression.This element-called a G/C repressor-is present in other SMC marker genes, and so the authors suggest that these additional marker genes would be similarly regulated.In addition to examining these genes, it will be interesting to see if KLF4 also controls the proliferation switch that contributes to plaque formation in atherosclerosis.
CLINICAL TEACHING.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Enzymes.
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Phase I Clinical and Pharmacokinetic Study of Carboplatin and Autologous Bone Marrow Support
Authors: Thomas C. Shea, Mary Flaherty, Anthony Elias, Joseph P. Eder, Karen Antman, Colin Begg, Lowell Schnipper, Emil Frei, William D. Henner
Journal: Journal of Clinical Oncology (1989)

The key to Fig 1 in the report by Shea et al published in the May issue (J Clin Oncol 7:651–661, 1989) contained several errors. It is reprinted here correctly with the figure in its entirety. Please see the PDF for Figure.
Facts versus ideology in the cloning debate
Authors: None The Lancet
Journal: The Lancet (2004)

Feb 21, 2024. 10 am, and I am waiting to hear whether I can have my pancreas transplant. When the doctors took out some of my eggs, replaced their nuclei, and induced them to become pancreatic cells, they warned me that, even 20 years after this technique was first described, the success rate was low. But I have got nothing to lose. Any remaining eggs I have will just die month by month. Why not use them to grow a new line of cells that might replace my failing pancreas?
Intravenous gammaglobulin‐associated acute renal failure
Authors: N. Gupta, I. Ahmed, S. Nissel‐Horowitz, D. Patel, B. Mehrotra
Journal: American Journal of Hematology (2001)

Intravenous gammaglobulins are used for the treatment of various auto-immune hematological disorders. Renal failure is a relatively rare, but an increasingly recognized side effect of gammaglobulin therapy. Although the renal failure is usually reversible, renal replacement therapy is required occasionally. A high index of suspicion, early recognition and appropriate intervention can prevent this complication. We herewith describe two patients with an immune hematological disorder, who developed acute renal failure after treatment with intravenous gammaglobulins. A brief review of the possible risk factors, pathophysiology and management of this complication is provided. Am. J. Hematol. 66:151–152, 2001. © 2001 Wiley-Liss, Inc.
Children's drawings and nuclear war
Authors: A. Brauner
Journal: JAMA (1986)

<b>Background: The Children of War</b>Certain experiences are never forgotten. During the Spanish Civil War (1936-1939), one of us (F.B.) worked as a physician and the other (A.B.) organized homes for children who had been evacuated from combat zones. Many of these children were pathetically shocked and grieved. Although we are neither "art therapists" nor psychologists, we felt that describing their experiences, in words or pictures, might help release the children from their memories. We offered them paper and pencils, but it was only several months later that they had recovered enough to be able to draw.<sup>1</sup>We attempted to hide these 10 000 drawings when the German army invaded Paris in 1940, but almost all were discovered and destroyed by the Gestapo. Fifty-six hidden by F.B. were rediscovered in a demolished house 30 years later.<sup>2</sup> In 1939, we cared for 130 Jewish children from Germany and Austria
Blood lead and blood pressure. Relationship in the adolescent and adult US population
Authors: W. R. Harlan
Journal: JAMA (1985)

Heavy lead exposure has been connected to cardiovascular disease, but modest exposures encountered in the general environment have not been associated previously with disease risk. The relationship between blood lead levels and blood pressures was examined using data from the second National Health and Nutrition Examination Survey. A direct relationship was found between blood lead levels and systolic and diastolic pressures for men and women and for white and black persons aged 12 to 74 years. Blood lead levels were significantly higher in younger men and women (aged 21 to 55 years) with high blood pressure, but not in older men or women (aged 56 to 74 years). In multiple regression analyses, the relationship of blood lead to blood pressure was independent of other variables for men, but not for women. Dietary calcium and serum zinc levels were inversely related to blood pressure. (<i>JAMA</i>1985;253:530-534)