tbuckley/cabot-search huggingface dataset:
Medizinische Welt, Stuttgart
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Neuroendocrinology
Authors: Seymour Reichlin
Journal: New England Journal of Medicine (1963)

Regulation of Thyrotropic-Hormone SecretionInitially conceived of as a sluggishly reactive system concerned primarily with long-term metabolic adjustments, the pituitary-thyroid axis has been shown to be quickly responsive to changes in blood levels of thyroid hormone,126 , 127 to changes in the external environment126 and to acute disturbances in brain function such as hypothalamic stimulation.128 As with the other pituitary-target-gland systems, impressive evidence has been marshaled that indicates that the regulation of thyrotropic function is influenced both by a feedback system involving thyroid and pituitary glands and by neural influences. How these two systems of control are integrated has been the subject . . .
An artifice of war
Authors: G. G. Liddle
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A prescription for the rising cost of medical care
Authors: V. H. Mark
Journal: JAMA (1977)

THE RECENT presidential and congressional elections have refocused public attention on the steeply rising cost of health care. Some influential critics have put the blame on new medical technologies and have suggested a moratorium on the installation of expensive medical equipment such as computerized tomographic scanning units. Other observers have indicted the malpractice crisis and the increasing tendency of physicians to practice "defensive medicine." The reputed list of excessive cost-producers includes nearly every person and institution taking part in the provision of health care. However, physicians remain the central figures in our medical system; and whether they are directly or indirectly involved in the financial crisis in medicine, they must share the responsibility and participate in any reasonable solution. At least three problem areas in medicine require change—change that can be initiated, or at least stimulated, by physicians. <h3>Outpatient Care</h3> There is general agreement that outpatient care is less expensive
Abstract LB-126: S100A14 promotes breast cancer metastasis via CCL2 dependent macrophage recruitment
Authors: Hongyan Chen, Xukun Li, Zhihua Liu
Journal: Cancer Research (2019)

Abstract S100A14 is a member of S100 calcium-binding protein family. Our previous studies have reported that S100A14 modulates a variety of tumorigenic processes by functioning both as intracellular and extracellular factors. Emerging evidence indicated that the biology of most S100 proteins is complex and multifactorial. Herein, we identify S100A14 is upregulated in Lymph Node (LN) metastasis breast cancer (BC) and associated with LN metastasis and prognosis. Through gain and loss of function approaches, we find that S100A14 promotes cell migratory and invasive capabilities in vitro and lung metastasis in vivo. More convincingly, S100A14 knockout also suppresses the lung metastases without affecting the primary tumor growth in MMTV-PyMT mouse models. Using a combination of iTRAQ based quantitative proteomics and transcriptomics, we identified CCL2 as a downstream target of S100A14. Importantly, systemic delivery of anti-CCL2 antibody significantly inhibited S100A14-enhanced cell migration and invasion, tumor-associated macrophages (TAMs) accumulation and lung metastasis. Finally, we indicated that the increased serum S100A14 levels could be used for the detection of BC and the prediction of LN metastases. These findings provide a plausible mechanism for S100A14-modulated tumor microenvironment in metastasis and show that S100A14-mediated CCL2 signaling plays a prominent role in breast cancer metastasis, which may have clinical implications for providing novel biomarkers and potential therapeutic targets of breast cancer in future. Note: This abstract was not presented at the meeting. Citation Format: Hongyan Chen, Xukun Li, Zhihua Liu. S100A14 promotes breast cancer metastasis via CCL2 dependent macrophage recruitment [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr LB-126.
SAT0757-HPR Significant improvement of rheumatoid arthritis (RA) outcome with repeated self-assessment applying smart system of disease management (SSDM) mobiles tools: a cohort study of RA patients in china
Authors: J Yang, Y Wang, F Li, H Wei, J Xue, H Wang, J Ru, R Mu, J Huang, X Zuo, X Xin, F He, X Shi, Z Li, F Xiao, H Xiao, Y Liu, Y Jia, Z Li
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> There are more than 5 million RA patients in China, but only 5,000 rheumatologists. Treat-to-Target (T2T) strategy are critical for the treatment of RA, but the Chinese rheumatologists can hardly provide patients with a complete assessment in the clinic due to limited time. The SSDM includes interfaces of both physicians9 and patients9 application. After entering the data of lab test records, treatment regiments, and executing DAS28 assessment by patients themselves, all data can be synchronized automatically to the authorized physicians9 mobile tool. The rheumatologists can adjust treatment regiments base on patients9 profile. Our previous study showed that patients in China can master the application of SSDM for accurately evaluating DAS28 and health assessment questionnaire (HAQ) after training. <h3>Objectives</h3> The purpose of this study is to explore the effectiveness of applying SSDM in improvement of disease activity after repeated self-assessment in Chinese RA patients. <h3>Methods</h3> Patients were educated to assess DAS28 with SSDM and asked to repeat the self-assessment once a month. Descriptive statistics were performed for patient and disease characteristics. According to DAS28 scores, disease activity was divided into four groups: remission (Rem), low disease activity (LDA), moderate disease activity (MDA) and high disease activity (HDA). <h3>Results</h3> From Aug 2014 to Jan 2017, a total of 11,867 RA patients from 459 centers in China participated in the study. The mean age was 49.27±14.35 (18 to 99) years and the median disease duration was 11.43 months. All patients performed self-assessment of DAS28, HAQ and morning stiffness time for 20,376 times. Proportion of patients in Rem, LDA, MDA and HDA was 16%, 12%, 46% and 25% respectively at baseline. Of which, 3,472 patients performed repeated assessment for 8,509 times. Proportion of patients in Rem, LDA, MDA and HDA changed into 34%, 18%, 38% and 10% at the last assessment. The proportion of T2T (DAS28 &lt;3.2) at the last assessment was higher than that of baseline significantly (P&lt;0.001). According to the assessments, the rate of T2T from baseline to 6 times were 28%, 41%, 49%, 51%, 56% and 58% (see Figure 1).With the increase of the times of self-assessment, the T2T rate was significantly improved (p&lt;0.001). <h3>Conclusions</h3> Under repeated self-assessment of DAS28 using SSDM, RA patients can achieve better T2T result. SSDM can assist rheumatologist to rationally adjust treatment for RA patients. <h3>Disclosure of Interest</h3> None declared
PRISON REFORM.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Illness Photography
Authors: Seth C. Hawkins
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Massachusetts Medical Society
Authors: John Figgis Jewett
Journal: New England Journal of Medicine (1958)

ARTHUR W. ALLEN, M.D.Dr. Arthur Wilburn Allen, president of the Massachusetts Medical Society from 1949 to 1950 and of the Boston Medical Library since 1952, was born in McKinney, Kentucky, on November 30, 1887, and died in Boston on March 18, 1958.Dr. Allen graduated from Georgetown College, in Kentucky, in 1909 and from Johns Hopkins Medical School in 1913. From then on his basic associations were with Boston and the Massachusetts General Hospital, for he started his surgical internship at the Hospital in 1913 and rose steadily to become chief of the East Surgical Service from 1936 to . . .
THE IMMORTALITY OF WORDS
Journal: JAMA (1960)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Quo Vadis?
Authors: LEMUEL C. MCGEE
Journal: Annals of Internal Medicine (1963)

Editorials1 January 1963Quo Vadis?LEMUEL C. MCGEE, M.D., F.A.C.P.LEMUEL C. MCGEE, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-1-192 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe phenomenal growth in a variety of prepayment plans to cover a major part of hospital and surgical costs for the care of patients is one of the remarkable socioeconomic developments on the North American continent during the past thirty years. Responding to the impetus of the depression following the 1929 financial debacle and the critical need to keep open hospital doors, Blue Cross plans rapidly became a way of life. Civic leaders, sociologists, hospital administrators, managers in industry, officers serving organized labor, welfare administrators, insurance actuaries, and many others became interested in the prepayment method to defray hospital and... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: 910 Market Street Wilmington, Delaware PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited by 1 January 1963Volume 58, Issue 1Page: 192-193KeywordsPatients ePublished: 1 December 2008 Issue Published: 1 January 1963 PDF downloadLoading ...
The safety of tricyclic antidepressants in cardiac patients. Risk-benefit reconsidered
Authors: A. H. Glassman
Journal: JAMA (1993)

IN 1977, we first reported the antiarrhythmic effect of imipramine hydrochloride.<sup>1</sup>Prior to that time, physicians generally believed that the tricyclic antidepressants (TCAs) caused arrhythmia. That belief stemmed from the propensity of overdoses of these drugs to provoke arrhythmias.<sup>2</sup>However, it subsequently became apparent, both from our studies<sup>3-6</sup>and the work of others,<sup>7</sup>that at plasma concentrations therapeutic for depression,<sup>8</sup>TCAs suppress arrhythmias, and their cardiac effects closely resemble those of class I antiarrhythmic drugs.<sup>9,10</sup>Until recently, it was our belief that depressed patients with preexisting arrhythmias would benefit from the antiarrhythmic effect of TCAs.<sup>11,12</sup>Unfortunately, recent studies indicate that this opinion may need to be revised. Ventricular premature depolarizations (VPDs) are a well-documented risk factor for sudden death after myocardial infarction (MI)<sup>13,14</sup>and the assumption had been that drugs that suppress VPDs would reduce this associated mortality. However, in 1983, Furberg
Studies on the Effects of Tolbutamide on Insulin Secretion
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The case for deregulating drug efficacy
Authors: R. Dorsey
Journal: JAMA (1979)

IN RECENT years growing dissatisfaction with existing federal drug law has been expressed by numerous groups. Physicians have complained of excessive delays in the introduction of new drugs and of growing intrusion by the Food and Drug Administration into the practice of medicine. The pharmaceutical industry has contended that resources are increasingly being shifted from productive research to administrative compliance. Consumerists, a predominantly young, healthy, and cause-oriented group, have berated the FDA for not regulating industry and physicians more tightly, to general approbation in the news media and Congress. On the other hand, genuine respresentatives of patients and the sick themselves have recently moved in precisely the opposite direction. For example, in the case of valproate sodium, the Epilepsy Foundation of America strongly urged the FDA and Congress to accelerate approval of this valuable new drug for seizure control.<sup>1,2</sup> Even more dramatically, cancer patients and their families have rejected
Medical News
Journal: JAMA (1974)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Human sources and absorption of vitamin K in relation to anticoagulation stability
Authors: J. A. Udall
Journal: JAMA (1965)

Available vitamin K was studied by serial prothrombin tests in ten anticoagulated and ten healthy subjects in one approach to the problem of long-term anticoagulation instability. Dietary manipulations of vitamin K produced a profound and predictable effect on anticoagulation stability. This fat soluble vitamin (K) is apparently not absorbed from the colon, probably the site of most bacterial synthesis. Foods, rather than intestinal bacterial synthesis, probably provide most vitamin K for humans.
Dyslipidemia
Authors: Laurie Kopin, Charles J. Lowenstein
Journal: Annals of Internal Medicine (2017)

Dyslipidemia is an important risk factor for coronary artery disease and stroke. Long-term, prospective epidemiologic studies have consistently shown that persons with healthier lifestyles and fewer risk factors for coronary heart disease, and particularly those with favorable lipid profiles, have reduced incidence of coronary heart disease. Prevention and sensible management of dyslipidemia can markedly alter cardiovascular morbidity and mortality.
Peroneal tenography
Authors: R. P. Eichelberger
Journal: JAMA (1982)

PERONEAL tenography, a radiological procedure, permits direct evaluation of peroneal tendon entrapment or displacement, as well as strong indirect evidence of calcaneofibular ligament tears. Although it has been described chiefly in the orthopedic literature previously, peroneal tenography is being requested of radiologists with increasing frequency. Our purpose is to describe the procedure and to present examples of the normal and abnormal findings that may be encountered. <h3>Indications</h3> Peroneal tenography provides anatomic definition of the peroneal tendons and their relationships to the lateral malleolus, calcaneus, and the lateral ligamentous structures of the ankle. The most common long-term complaints following fracture of the calcaneus are stiffness and inability to control the foot and ankle.<sup>1</sup>This inability results frequently in twisting or spraining the foot and ankle, as the patient is unable to resist the turning in (inversion) of the foot, particularly on irregular surfaces. Anatomically, this disability can be ascribed to
Highlights
Journal: JAMA (2017)

Exercise is associated with improved survival in the general population, but individuals with hypertrophic cardiomyopathy who participate in competitive athletics are at risk for sudden cardiac death.In a randomized clinical trial by Saberi and colleagues of 136 patients with hypertrophic cardiomyopathy, 16 weeks of moderate-intensity exercise training, compared with usual activity, resulted in a statistically signifi cant but small increase in exercise capacity.In an Editorial, Owens and Cappola caution that the fi ndings of this trial are preliminary, and they recommend larger studies with longer durations of follow-up to assess the safety of recreational exercise for patients with hypertrophic cardiomyopathy.