tbuckley/cabot-search huggingface dataset:
THE NEW GENUS OF SPIROCHETE— LEPTOSPIRA
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Journal of Neurosurgery, Chicago
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
More Than 1,700 Attend Congress on Mental Illness
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
In Vitro Analysis of Multistage Carcinogenesis
Authors: P. Nettesheim, D. J. Fitzgerald, H. Kitamura, C. L. Walker, T. M. Gilmer, J. C. Barrett, T. E. Gray
Journal: Environmental Health Perspectives (1987)

Several key events in the multistep process of neoplastic transformation of rat tracheal epithelium (RTE) are described. Whether tracheal epithelium is exposed in vivo to carcinogenic agents or whether primary tracheal epithelial cells are exposed in vitro to carcinogens, initiated stem cells can be detected soon after the exposure by their ability to grow under selective conditions in culture. These initiated stem cells differ fundamentally from normal stem cells in their response to factors normally constraining proliferation and self-renewal. Thus, disruption of inhibitory control mechanisms of stem cell replication appears to be the first event in RTE cell transformation. While the probability of self-renewal (PSR) is clearly increased in initiated stem cells, most of the descendants derived from such stem cells differentiate and become terminal and do not express transformed characteristics. Progression from the first to the second stage of RTE cell transformation, the stage of the immortal growth variant (IGV), is characterized by loss of responsiveness to the growth-restraining effects of retinoic acid. In the third stage of neoplastic transformation, the stage during which neoplastic growth variants (NGV) appear, a growth factor receptor gene is inappropriately expressed in some of the transformants. Thus, it appears that loss of growth-restraining mechanisms may be an early event, and activation of a growth stimulatory mechanism a late event, in neoplastic transformation of RTE cells.
THE RECOGNITION OF GLAUCOMA BY THE GENERAL PRACTITIONER.
Authors: EDWARD JACKSON
Journal: JAMA (1884)

In his address, upon assuming the Presidency of the Opthalmological Society of the United Kingdom of Great Britain and Ireland, in October of last year, Jonathan Hutchinson said: "There is no one present who has not been pained over and over again by having to treat cases of glaucoma which were brought to him too late. In spite of all that has been done by specialists, and in spite of the fame which iridectomy cures have obtained, it is still the fact that a large proportion of the cases of acute glaucoma are unrecognized during the first fortnight by those under whose observation the patients come." Dr. Chisolm, chairman of the Section on Ophthalmology, in his address before the American Medical Association, May, 1884, says: "Very seldom does a specialist see a case of glaucoma diagnosed as such by the family physician." Doubtless this truth is felt by everyone specially
Quantitative flow cytometry for the differential diagnosis of leukemic B‐cell chronic lymphoproliferative disorders
Authors: Giovanni D'Arena, Pellegrino Musto, Nicola Cascavilla, Matteo Dell'Olio, Nicola Di Renzo, Mario Carotenuto
Journal: American Journal of Hematology (2000)

We have investigated whether the quantitative flow cytometry is an useful tool to better characterize B-cell chronic lymphoproliferative disorders (CLDs). Peripheral blood samples from 104 patients with leukemic B-cell disorders and 20 healthy donors were analyzed. Directly phycoerythrin-conjugated CD19, CD20, CD22, CD23, CD79b, and CD5 monoclonal antibodies (MoAbs) and QuantiBRITE pre-calibrated beads were used to calculate the number of antigen molecules per cell, expressed as antibody binding capacity (ABC). As compared to normal controls, in chronic lymphocytic leukemias (CLL) all MoAbs tested, with the exception of CD23 and CD5, showed lower ABC levels. In prolymphocytic leukemias (PL), CD5 and CD23 antigens were constantly absent while lower CD19 and CD22 ABC levels were observed. Hairy cell leukemias (HCL) displayed very high levels of CD20 and CD22. Of interest, splenic lymphomas with villous lymphocytes (SLVL) could be discriminated from HCL for higher CD79b and lower CD19 ABC values. Finally, higher CD20 levels were detected in follicular lymphomas (FL), whereas higher CD79b and CD5 levels characterized mantle cell lymphomas (MCL). Seven out of 61 CLL cases were defined as morphologically atypical. When compared with typical forms, lower levels of CD19 and CD23 and higher CD20 and CD22 ABC values were detected. However, we failed to demonstrate quantitative differences between atypical CLL and MCL. Our results suggest that quantitative flow cytometry may be a useful additional tool to better identify some types of B-cell CLDs. Am. J. Hematol. 64:275–281, 2000. © 2000 Wiley-Liss, Inc.
Intravascular and total body platelet equilibrium in healthy volunteers and in thrombocytopenic patients transfused with single donor platelets
Authors: Daniel B. Brubaker, Carol Marcus, Edwin Holmes
Journal: American Journal of Hematology (1998)

Instrument platelet counts used in corrected count increment (CCI) and percent platelet recovery (PPR) formulas presume the transfused platelets are in equilibrium during the first hour after platelet transfusion.The timing of the pre-transfusion count affects CCI results, and we postulate that timing of CCI post transfusion affects CCI results.Platelet equilibrium using indium-111 platelet transfusions has not been reported.Platelet redistribution was studied in 16 healthy volunteers and 12 thrombocytopenic patients by generally infusing less than 72-hr stored single-donor platelets along with an aliquot of indium-111-labeled platelets by intravenous push.Counts were measured at 10, 15, 20, 60, and 120 min, and 24, 48, 72 hr along with continuous body scanning for 2 hr in healthy volunteers, and static organ scanning in patients and volunteers.Results indicated transfused platelets do not reach intravascular equilibrium for 60 min post-infusion and that the 10-min count cannot detect platelet refractoriness.However, total body equilibrium varies considerably between normal volunteers and thrombocytopenic patients.It is recommended to continue with the 1-hr post transfusion count.Am.
Psychophysiological responses to anesthesia and operation
Authors: J. G. Williams
Journal: JAMA (1968)

Each year millions of patients undergo operations, and to many, this constitutes the ultimate threat and produces maximal stress. Those of us to whom hospital procedures are routine often fail to recognize the extent of the patient's anxiety; consequently we ignore the implications of Alexander's observation that "every emotional state has its own physiological syndrome"<sup>1</sup>and we neglect to take into account the role of anxiety as a determinant of the patient's physiological status immediately prior to and during anesthesia and operation. The pilot study reported here was undertaken in order to make possible a preliminary assessment of the degree and patterns of autonomic activity under these circumstances. Evaluations of stress and drugs to suppress stress have often been accomplished by psychological testing, but this does not permit continuous objective monitoring. Psychophysiological techniques frequently employ the<i>continuous</i>and simultaneous recording of several physiological variables in order to increase the
22. Creation of a Biological Pacemaker by Cell Fusion
Authors: Hee Cheol Cho, Yuji Kashiwakura, Eduardo Marbán
Journal: Molecular Therapy (2006)

As an alternative strategy to electronic pacemakers or to gene therapy/stem cell approaches, we explored the feasibility of converting ventricular myocytes into pacemakers by cell fusion. The idea is to create chemically-induced heterokaryons between ventricular myocytes and syngeneic fibroblasts engineered to express pacemaker ion channels, HCN1.
Abstract 12621: Gender Differences Among Implantable Cardioverter Defibrillators Recipients in the Setting of Primary Prevention
Authors: Eloi Marijon, Rui Providencia, Pascal Defaye, Didier Klug, Daniel Gras, Vincent Algalarrondo, Jean-Claude Deharo, Christophe Leclercq, Laurent Fauchier, Dominique Babuty, Pierre Bordachar, Nicolas Sadoul, Olivier Piot, Serge Boveda
Journal: Circulation (2015)

Background: Data regarding sex specificities in the use, benefits and complications of implantable cardioverter-defibrillators (ICDs) in primary prevention in the real-world European setting are sparse. Methods: Using a large multicentric cohort of consecutive patients referred for ICD implantation for primary prevention (2002-2012), in the setting of coronary artery disease or dilated cardiomyopathy, we examined potential sex differences in subjects’ characteristics and outcomes. Results: Of 5,539 patients, only 837 (15.1%) were women and 53.8% received cardiac resynchronization therapy (CRT-D). Compared to men, women presented a significantly higher proportion of dilated cardiomyopathy (60.2% vs. 36.2%, P120ms: 74.6% vs. 68.5%, P=0.003), higher New York Heart Association functional class (2.5±0.7 vs. 2.4±0.7, P=0.003) and lower prevalence of atrial fibrillation (18.7% vs. 24.9%, P&lt;0.001). During a 16,786 patient-years follow-up, overall, fewer appropriate therapies were observed in women (HR = 0.59, CI95% 0.45-0.76; P&lt;0.001). By contrast, no sex-specific interaction was observed for inappropriate shocks (OR for women = 1.00, 95%CI 0.74-1.35, P=0.997) and mortality (HR = 0.87; 95%CI 0.66-1.15, P=0.324), with similar patterns of cause of deaths. Conclusion: In our real life registry, women account for the minority of ICD recipients. While female ICD recipients present with features of more severe heart failure in the setting of primary prevention of sudden cardiac death, we observed they have a 40% lower incidence of appropriate therapies.
Action of Drugs in Health and Disease.
Journal: JAMA (1910)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bacterial Resistance to Chemotherapy
Journal: BMJ (1952)

Ehrlich's work on chemotherapy was closely linked to and much stimulated by the rapid advances in organic chemistry which were occurring at that time in cTermanyand his work was greatly facilitated by the concomitant extraordinary expansion of the German dyestuffs industry.Ehrlich, and later Domagk, tested dyestuffs for chemotherapeutic activity and in 1935 Domagk announced that prontosil (red) would cure streptococcal infections in mice.This discovery was a most important milestone in the development of chemotherapy, for it was shown for the first -time that anti-bacterial chemotherapy was a practical possibility.This observation was immediately confirmed in France.Contrary to Ehrlich's concepts, however, the chemotherapeutic effectiveness of prontosil was not due to its dye nature, but resided in the non -coloured sulphonamide moiety of the prontosil molocule.It was soon shown that numerous sulphonamide compounds were effective not only against streptococci but had a chemotherapeutic effect over a considerable range of bacterial infections.A second great advance in chemotherapy was initiated by the introduction into medicine of the antibiotics.Intensive research on antibiotics began in 1940 when Chain and Florey announced that penicillin, a metabolic product of Penicillium notatum and whose existence had been observed eleven years previously by Fleming (1928), possessed remarkable curative properties in experimental animal infections.From that time on the development of the literature on the antibiotics has shown/
Society Proceedings
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Different response of the rat left and right heart to norepinephrine
Authors: M Irlbeck
Journal: Cardiovascular Research (1996)

The in vivo hemodynamic and morphologic responses of the rat left (LV) and right (RV) ventricle to continuous long-term i.v.infusion of norepinephrine (NE) at different dosages and for different durations of infusion were studied.Female Sprague-Dawley rats received continuous intravenous infusion of norepinephrine from infors" syringe pumps for 24, 48 and 12 h at a dose of 200 pg.kg-'.h-l.Furth ermore, NE was infused for 72 h at dosages of 50, 100 and 200 pg.kg-' .h-'.The beta-adrenergic blocker and vasodilator with alpha,-blocking activity carvedilol (0.5 mg .kg-' .h-'> was coinfused with NE for 72 h.The hemodynamic effects were measured on intact, anesthetized rats with special Millar'@ ultraminiature.pressure tip catheters, and the weights of the left and right ventricles were measured.NE increased heart rate at any time or dose, whereas cardiac output and total peripheral resistance remained unchanged.LV and RV d P/d t,, were nearly doubled as compared to control values and RVSP was elevated by more than 100%.The effect of NE on LVSP was much less pronounced ( < 20%) and only significant at 50 pg .kg-' h-' for 72 h.Neither LV nor RV end-diastolic pressures were elevated, indicating that cardiac failure had not occurred.The LV developed hypertrophy with an increase of the ventricular weight/body weight ratio (LVW/BW) of 22% even after only 2 days of NE (200 pg.kg-' .h-').The RV showed no hypertrophy at any time of the experiments.The NE-induced changes in HR, d P/d t,, , RVSP and LVW/BW were completely prevented by the coinfusion of carvedilol.These studies show that the hemodynamic responses to continuous infusion of NE are more pronounced in the RV than in the LV.Conversely, NE induced hypertrophy only in the LV, not in the RV.The hemodynamic effects of chronic NE infusion did not change significantly between 1 and 3 days of infusion.The in vivo responses to exogenous NE therefore were unaffected by adaptive effects such as downregulation of adrenergic receptors.
STrengthening the REporting of Genetic Association Studies (STREGA): An Extension of the STROBE Statement
Authors: Julian Little
Journal: Annals of Internal Medicine (2009)

Making sense of rapidly evolving evidence on genetic associations is crucial to making genuine advances in human genomics and the eventual integration of this information into the practice of medicine and public health. Assessment of the strengths and weaknesses of this evidence, and hence the ability to synthesize it, has been limited by inadequate reporting of results. The STrengthening the REporting of Genetic Association studies (STREGA) initiative builds on the STrengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement and provides additions to 12 of the 22 items on the STROBE checklist. The additions concern population stratification, genotyping errors, modeling haplotype variation, Hardy-Weinberg equilibrium, replication, selection of participants, rationale for choice of genes and variants, treatment effects in studying quantitative traits, statistical methods, relatedness, reporting of descriptive and outcome data, and issues of data volume that are important to consider in genetic association studies. The STREGA recommendations do not prescribe or dictate how a genetic association study should be designed but seek to enhance the transparency of its reporting, regardless of choices made during design, conduct, or analysis.
Screening tests for nursing home patients
Authors: A. L. Komaroff
Journal: JAMA (1987)

Approximately 1.5 million individuals are cared for in more than 18 000 nursing homes in the United States. The number is expected to double in the next ten to 20 years. Admission to a nursing home is a wrenching change for any patient, a change often made more devastating by an interruption in the continuity of medical care. It is uncommon for the patient's previous physician to follow the patient into the nursing home. Furthermore, a well-organized summary of past medical care does not often accompany the patient to the nursing home. Finally, in many nursing homes the initial evaluation by the new physician is often brief. As Golodetz<sup>1</sup>has pointed out, the examination often fails to focus on the chief problems of functioning in the elderly: it does not include a detailed evaluation of the musculoskeletal system or assessment of cognition, the functioning of the special senses, or
Letter: Prisoners and their health.
Authors: I Gordon-Smith, J Hickman
Journal: BMJ (1975)

It is our ontention that, though there is some evidence that venous thrombosis after operation and impaired fibrinolysis are re- lated, the link is still only tenuous and un- likely to be of major importance.This would explain on the one hand why prophylactic regimens sudh as phenformin and ethyl- oestrenol (which increase fibrinolytic activity) have not been effective in preventing postoperative venous thuombosis7 and on the other hand why a powerful fibrinolytic in- hibitor E-amnnoaproic acid, admiiinistered during the perioperative period was not associated with an increased incidence of deep vein xirombosis.8-We are, etc.,
Incorrect Test Characteristic
Journal: JAMA (2016)

In the JAMA Diagnostic Test Interpretation entitled "Elevated Hemoglobin or Hematocrit Level," 1 published in the May 24/31, 2016, issue of JAMA, a test characteristic was incorrectly described.The sentence that read as follows: "Typically, JAK2V617F is quantitatively reported as picogram of JAK2V617F per microliter of plasma (Medicare reimbursement cost of testing, $124.87),although qualitative tests are available."should have read in the following way: "Typically, JAK2V617F is quantitatively reported as a percentage of extracted genomic DNA found to have the point mutation causing JAK2V617F (Medicare reimbursement cost of testing, $124.87),although qualitative tests are available."This article was corrected online.