tbuckley/cabot-search huggingface dataset:
Miscellany
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MEDICAL JOURNALS AND COMMERCIALISM.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An Address Delivered at the Opening of the Section of Medicine
Authors: S. Wilks
Journal: BMJ (1885)

time after time, but there is a particular reason for now moving in this direction.The first Report of the Royal Commission for inquiring into the Housing of the Working Clases has been published.The Commis- sioners say that public opinion must be the moving power.Through this assembly, I appeal to that public opinion to move those who have the power to take this one step forward in the path of progress and of orderly supervision.The step, if taken, would not be costly, as it would need merely a readjustment of duties, and certain changes of redence from town to country.I feel convinced that, if sanitary superintendents, having authority in well defined districts, were appointed, in a very few years such a clear elucidation of the removable causes of disemes would be ob- tained; such definite means for their removal would be pointed out; such a thorough organisation of an efficient sanitary service would be produced, that the working of the laws for the promotion of the public health would be thoroughly effective, and tihe benefit to the people immense.In making this appeal to you, that this fancy of mine, long held and frequently proclaimed, may be realised, I will " rely upon that, without which all fancy sooner or later dies, upon that which, once received into the heart, is the basis of untiring faith-I will rely upon Hope.
Exposure to Mercury Alters Early Activation Events in Fish Leukocytes
Authors: Kent C. MacDougal, Matthew D. Johnson, Karen G. Burnett
Journal: Environmental Health Perspectives (1996)

Although fish in natural populations may carry high body burdens of both organic and inorganic mercury, the effects of this divalent metal on such lower vertebrates is poorly understood. In this report, inorganic mercury in the form of mercuric chloride (HgCl2) is shown to produce both high-dose inhibition and low-dose activation of leukocytes in a marine teleost fish, Sciaenops ocellatus. Concentrations of inorganic mercury > or = 10 microM suppressed DNA synthesis and induced rapid influx of radiolabeled calcium, as well as tyrosine phosphorylation of numerous cellular proteins. Lower concentrations (0.1-1 microM) of HgCl2 that activated cell growth also induced a slow sustained rise in intracellular calcium in cells loaded with the calcium indicator dye fura-2, but did not produce detectable tyrosine phosphorylation of leukocyte proteins. These studies support the possibility that subtoxic doses of HgCl2 may inappropriately activate teleost leukocytes, potentially altering the processes that regulate the magnitude and specificity of the fish immune response to environmental pathogens.
Reply to Nirmish Singla and Vitaly Margulis’s Letter to the Editor re: Geraldine Pignot, Antoine Thiery-Vuillemin, Jochen Walz, et al. Nephrectomy After Complete Response to Immune Checkpoint Inhibitors for Metastatic Renal Cell Carcinoma: A New Surgical Challenge? Eur Urol. In press. https://doi.org/10.1016/j.eururo.2019.12.018. The Next Surgical Frontier in Kidney Cancer: Nephrectomy After Immune Checkpoint Inhibition
Authors: Géraldine Pignot, Antoine Thiery-Vuillemin, Jochen Walz, Pierre Bigot, Karim Bensalah, Gwenaelle Gravis, Philippe Barthélémy
Journal: European Urology (2020)
表皮熟化、维生素C与透明质酸代谢
Authors: L. Hämäläinen, E. Kärkkäinen, P. Takabe, L. Rauhala, G. Bart, R. Kärnä, S. Pasonen-Seppänen, S. Oikari, M.I. Tammi, R.H. Tammi
Journal: British Journal of Dermatology (2018)

表皮是人体皮肤表层,由角质细胞组成。角质细胞会在皮肤更深层分裂(产生更多细胞)并逐渐移向表面。角质细胞最终在皮肤表面形成死亡细胞层,作为主要防护屏障来抵御可能损害或刺激皮肤的因素,比如化学物质和细菌。而在更下方的活细胞层中,角质细胞周围存在一种被称为透明质酸的黏性物质。各种表皮损伤(比如创伤、感染和晒伤)都会引发角质细胞出现强烈的炎症反应。这些反应包括角质细胞分裂增加、角质细胞移动帮助损伤部位恢复以及透明质酸生成和流动增加。许多皮肤病都是由于角质细胞对损伤出现过度(甚至是完全多余的)反应,从而造成危害。因此,用于平息这一反应的因素和治疗是某些皮肤病的潜在用药之策。本项研究在芬兰库奥皮奥开展,研究了透明质酸在实验室开发的特殊模型中的代谢(即分裂);在该模型中,角质细胞会分离,产生看上去正常的表皮。通过此模型,研究人员证明,维生素C能够抑制透明质酸在表皮中的生成和降解。由于透明质酸迅速代谢是炎症的征兆,因此抗氧化剂维生素C也许能够用于抑制角质细胞的反应。本项研究需要通过更多工作来了解维生素在临床实践中的作用机制以及可能作用。
Ricky
Authors: Patricia Taner Leff
Journal: JAMA (1988)

The subway lurched as my eyes swung past headlines routinely dotting the urban landscape: "Teen Arrested in School Rape." A jolt. I read and reread the name—a child's name. Ricky. Ricky indeed would be 15 years old this year. Could that chubby, troubled 9-year-old boy I had known and treated so many years ago be today's "teen monster," a molester of little girls? Memories of Ricky. Ricky's world of rage and of sadness. "Mommy," the maternal grandmother (a diabetic woman in her 60s who required extensive medical attention), was his caretaker. She gasped for breath and struggled to regain her composure. "Dr Leff, he was 30 pounds and 5 years old when I got him. With the help of the Lord.... Look at him now.... My daughter drank too much.... My daughter...." She sighed and fixed her eyes on the fat, morose boy grimly drawing in the corner. "Ricky, stand
Questions and Answers
Journal: JAMA (1961)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Review of Surgical Aortic Valve Repair. Indications and techniques for the General Cardiologist
Authors: Jeremy Docekal
Journal: Clinical Cardiology and Cardiovascular Interventions (2020)

In a recently published study on this topic, the authors conclude that their study found a "shorter life expectancy in patients after aortic valve replacement (AVR) compared with the general population.The estimated loss in life expectancy was substantial, and increased with younger age (Figure 1) [1]."Their observation may be explained, in part, by the fact that longer life expectancy predicts increased exposure to prostheticvalve-related complications such as degeneration leading to reoperation, bleeding, and thromboembolism [2].
Correction.
Authors: Jas. T. Jelks
Journal: JAMA (1897)

Hot Springs, Ark., Nov. 26, 1897. <h3>To the Editor:</h3> —On page 1065 of yourJournal, in the discussion of the paper by Dr. C. A. L. Reed, entitled "Gall Stones in their Relation to Cancer of the Gall Ducts," in the last line on said page the reporter makes me say that I had "seen cancer of the uterus unmistakably produced by gall stone infection." Of course there is a mistake in this on the part of the reporter. It should have been "liver" instead of "uterus." Yours truly,
Treatment of hemolytic anemia due to red blood cell fragmentation using recombinant human erythropoietin
Authors: B. Gitler
Journal: JAMA (1995)

<h3>To the Editor.</h3> —Since 1989, recombinant human erythropoietin has been available for management of the anemia of end-stage renal disease.<sup>1</sup>There have been reports of the use of erythropoietin in the treatment of other anemias, including anemia of malignancy associated with bone marrow infiltration,<sup>2</sup>anemia of prematurity,<sup>3</sup>zidovudine-induced anemia in human immunodeficiency virus infection,<sup>4</sup>anemia of myelodysplastic syndromes,<sup>5</sup>and anemia of rheumatoid arthritis.<sup>6</sup>I describe two patients who had hemolytic anemia due to red blood cell (RBC) fragmentation in association with prosthetic heart valves. They were treated with erythropoietin, which eliminated their need for blood transfusions. The first patient was a 75-year-old woman who had rheumatic heart disease and double valve replacement in December 1985 for aortic and mitral stenosis. She received a Starr-Edwards aortic valve and a Medtronic-Hall mitral valve. Eighteen years prior to her heart surgery, she had a splenectomy after a
Gallbladder Disease as a Side Effect of Drugs Influencing Lipid Metabolism Experience in the Coronary Drug Project
Journal: New England Journal of Medicine (1977)

We analyzed data obtained during the Coronary Drug Project to discover the influence of the drugs used on the frequency of gallbladder disease. Of 2680 placebo-treated men who had had myocardial infarction, gallbladder disease developed in 69. Corresponding figures for those given 2.5 mg of estrogen, 5.0 mg of estrogen and 1.8 g of clofibrate per day were 46 of 1061, 47 of 1081 and 42 of 1051, respectively. Each treatment group differed from placebo by over twice the standard error of the difference, life-table analysis yielding P less than 0.05 for each drug-placebo comparison. Forty-five variables, including age, body weight, blood pressure, serum lipids and blood sugar, were evaluated as risk factors. Age significantly correlated with prevalence of known gallbladder disease at entry (r = 0.066, P less than 0.001). No variable yielded a strong and consistent correlation with the incidence of subsequent new gallbladder disease. Gallstone formation is a risk whenever clofibrate or estrogen is prescribed.Data obtained during the Coronary Drug Project were analyzed to determine the influence of drugs on the frequency of gall bladder disease. All subjects were males with a history of myocardial infarction. The cholesterol-lowering drugs tester were mixed conjugated equine estrogens in doses of 2.5 and 5 mg/day, clofibrate 1.8 gm/day, dextrothyroxine 6 mg/day, nicotinic acid 3 gm/day, and placebos. The observation period was over 5 years. Patients receiving clofibrate and both estrogen dosage groups had the highest incidence of cholecystitis or cholelithiasis. Each treatment group, except those taking dextrothyroxine, exceeded the placebo-taking group in incidence of gallbladder disease (p .05). Of 45 variables evaluated as risk factors, only age of the subject correlated with incidence of gallbladder disease prior to the tests (p .001). None of these variables gave a constant correlation with the incidence of subsequent new gallbladder disease. The development of gallstones must be accepted as an anticipated risk whenever estrogens or clofibrate are prescribed.
Paleopathology
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sunlight, skin cancer, and suncreens
Authors: L. H. Kaminester
Journal: JAMA (1975)

THE SOLAR electromagnetic spectrum ranges widely from below the short ultraviolet wavelength through the visible light spectrum and beyond. The ozone in our stratosphere 25 km above the earth effectively protects us from the short-wave, highenergy ultraviolet (UV) light. But UV light that does penetrate the atmosphere contains the erythrogenic spectrum that causes the all-too-familiar sunburn reaction. Redness begins two to eight hours after exposure and usually peaks at 24 hours. When the exposure has been longer than five times the minimum erythema dose (MED) (ie, the amount of energy from a defined light source, like the sun, producing a barely perceptible sunburn or erythema of the skin under stated conditions), blistering, pain, and fever may also occur. Although immediate darkening of pigment may accompany such erythema, due to oxidation of colorless preformed melanin already in the skin, it is transient, fading within a few hours. The socially sought-after, durable
Drugs Related to the Exacerbation or Amelioration of Hepatic Coma and Their Effect on Ammonia Toxicity
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Vagotomy
Authors: Arthur E. Baue
Journal: JAMA (1965)

This concise monograph traces the development of vagotomy for the treatment of peptic ulcer disease, from the therapeutic implications of Pavlov's studies and Dragstedt's contributions, to selective vagotomy currently being evaluated. The book includes sections on gastric physiology, applied anatomy of the vagus nerves, the effects of vagal denervation, postvagotomy diarrhea, and incomplete nerve section, all clearly described, and based on the author's own work as well as that of others. Much of the book is devoted to the present place of vagotomy in the treatment of duodenal ulcer, gastric ulcer, the pyloric channel syndrome, stomal ulcer, and hiatus hernia with esophagitis. Since this procedure is never performed alone except for stomal ulcer, but is combined with a drainage procedure, ie, pyloroplasty or gastroenterostomy, the title might more descriptively have been "Vagotomy and Drainage Procedures for Ulcer Disease." Incomplete nerve section producing persistent gastric hypersecretion, inadequate drainage of the antrum,
A Randomized Trial of Intrapartum Fetal ECG ST-Segment Analysis
Authors: Michael A. Belfort, George R. Saade, Elizabeth Thom, Sean C. Blackwell, Uma M. Reddy, John M. Thorp, Alan T.N. Tita, Russell S. Miller, Alan M. Peaceman, David S. McKenna, Edward K.S. Chien, Dwight J. Rouse, Ronald S. Gibbs, Yasser Y. El-Sayed, Yoram Sorokin, Steve N. Caritis, J. Peter VanDorsten
Journal: New England Journal of Medicine (2015)

It is unclear whether using fetal electrocardiographic (ECG) ST-segment analysis as an adjunct to conventional intrapartum electronic fetal heart-rate monitoring modifies intrapartum and neonatal outcomes. We performed a multicenter trial in which women with a singleton fetus who were attempting vaginal delivery at more than 36 weeks of gestation and who had cervical dilation of 2 to 7 cm were randomly assigned to "open" or "masked" monitoring with fetal ST-segment analysis. The masked system functioned as a normal fetal heart-rate monitor. The open system displayed additional information for use when uncertain fetal heart-rate patterns were detected. The primary outcome was a composite of intrapartum fetal death, neonatal death, an Apgar score of 3 or less at 5 minutes, neonatal seizure, an umbilical-artery blood pH of 7.05 or less with a base deficit of 12 mmol per liter or more, intubation for ventilation at delivery, or neonatal encephalopathy. A total of 11,108 patients underwent randomization; 5532 were assigned to the open group, and 5576 to the masked group. The primary outcome occurred in 52 fetuses or neonates of women in the open group (0.9%) and 40 fetuses or neonates of women in the masked group (0.7%) (relative risk, 1.31; 95% confidence interval, 0.87 to 1.98; P=0.20). Among the individual components of the primary outcome, only the frequency of a 5-minute Apgar score of 3 or less differed significantly between neonates of women in the open group and those in the masked group (0.3% vs. 0.1%, P=0.02). There were no significant between-group differences in the rate of cesarean delivery (16.9% and 16.2%, respectively; P=0.30) or any operative delivery (22.8% and 22.0%, respectively; P=0.31). Adverse events were rare and occurred with similar frequency in the two groups. Fetal ECG ST-segment analysis used as an adjunct to conventional intrapartum electronic fetal heart-rate monitoring did not improve perinatal outcomes or decrease operative-delivery rates. (Funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development and Neoventa Medical; ClinicalTrials.gov number, NCT01131260.).
Erratum: LEF-1 is crucial for neutrophil granulocytopoiesis and its expression is severely reduced in congenital neutropenia
Authors: Julia Skokowa, Gunnar Cario, Murat Uenalan, Axel Schambach, Manuela Germeshausen, Karin Battmer, Cornelia Zeidler, Ulrich Lehmann, Matthias Eder, Christopher Baum, Rudolf Grosschedl, Martin Stanulla, Michaela Scherr, Karl Welte
Journal: Nature Medicine (2006)
Dermatologic Therapy
Authors: John G. Downing
Journal: New England Journal of Medicine (1953)

THE older the dermatologist, the fewer the drugs he uses. Dermatologic therapy is quite an art. The trained observer makes the correct diagnosis and fits the therapy to the various stages of the eruption and the attending complications. Despite the many new "wonder drugs," well established methods of therapy are still needed. Although the necessary medicaments may be few, external therapy cannot be limited to tap water and vaseline, for the patient expects and should have relief and suitable therapy to shorten the course of his disease, even a self-limited one. There is still need for proper local therapy, and . . .