tbuckley/cabot-search huggingface dataset:
The Public Service.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lettsomian Lectures on the Pathology and Treatment of Some Diseases of the Liver
Authors: S. O. Habershon
Journal: BMJ (1872)

THE connection of the liver with the nervous system occupied our at- tention at the last lecture, and we will now pass to the consideration of some of those pathological conditions which are connected with the vascular supply of the gland.The hepatic veins, the vena portie, and the hepatic artery, constitute three blood-channels to or from the gland; they unite at the. minute lobules, but the import of their pathological
Deaths.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AB0085 Serum Levels of CXCL13 Are Increased in Untreated Patients with Rheumatoid Arthritis from the First Weeks of Disease Development
Authors: R.A. Moura, H. Canhão, J. Polido-Pereira, M. Navalho, M.J. Leandro, G. Cambridge, J.E. Fonseca
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> CXCL13 (C-X-C motif ligand 13), also known as B-cell chemo-attractant, is an important B-cell chemokine that directly affects the migration and organization of B cells within follicles of lymphoid tissues. CXCL13 plays an important role as a major regulator of B-cell recruitment towards secondary lymphoid organs and inflammatory sites and it has recently been proposed as a serum biomarker of synovitis in patients with rheumatoid arthritis (RA). <h3>Objectives</h3> The aim of this study was to quantify CXCL13 serum levels in untreated very early polyarthritis patients to understand the dynamics of B-cell trafficking since early disease onset. <h3>Methods</h3> CXCL13 levels were measured by ELISA in serum samples from untreated very early RA (VERA) with &lt;6 weeks of disease duration, and compared with arthritis due to other conditions of the same duration (non-RA) (VENRA), untreated early RA (ERA) (&lt;1 year), other early arthritis patients (non-RA) (ENRA) (&lt;1 year), established treated RA and healthy controls (HC). Statistical analysis was performed with Mann-Whitney, Kruskal-Wallis and Spearman tests (p&lt;0.05). <h3>Results</h3> We found that untreated polyarthritis patients with &lt;6 weeks of disease duration (VERA and VENRA) had significantly higher CXCL13 serum levels in comparison with HC (p=0.01 and p=0.02, respectively). ERA and established RA patients also had significantly higher circulating levels of CXCL13 when compared to HC (p=0.04 and p=0.003, respectively), but no significant differences were observed in comparison with VERA. Moreover, no significant differences were found in ENRA patients when compared to HC. However, all patients diagnosed with RA (VERA, ERA and established RA) had significantly higher levels of CXCL13 when compared to ENRA (p&lt;0.05). VENRA also had significantly higher CXCL13 levels when compared to ENRA. Furthermore, no correlation was observed between CXCL13 serum levels with age, DAS28, ESR, VAS, tender and swollen joint counts. <h3>Conclusions</h3> CXCL13 serum levels were significantly increased in untreated polyarthritis patients who subsequently resolved into a clinical diagnosis of RA. This was found in both early RA cohorts (VERA and ERA). Although VERA and VENRA (&lt;6 weeks of disease duration) had similar CXCL13 levels, only ERA and not ENRA had significantly higher levels suggesting that chronicity was strongly associated with CXCL13 in RA patients. Overall, our results might reflect an interaction between CXCL13-producing cells (activated macrophages, follicular dendritic cells, or Th17-cells) with B-cells in secondary lymphoid tissues such as the spleen, lymph nodes and possibly in inflammatory sites i.e., joints. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.2281
Condylomata acuminata.
Authors: M Waugh
Journal: BMJ (1972)

idealistic perfection, our's of the practical care of children.Finally, a standard dosage regimen recom- mended for nitrofurantoin is 7 mg/kg/24 hours.'For a 2-year-old weighing approximately 12 kg 75 mg per day is not excessive.Not being blessed with foresight, we were not able to foresee the results firom Professor de Wardener's department that Dr. Bailey refers to,2 as these had not been published at the time we draf:ed our article, let alone at the time we were treating the child con- oerned.-Weare, etc.,
Concurrent thrombotic thrombocytopenic purpura and immune thrombocytopenic purpura in an HIV‐positive patient: Case report and review of the literature
Authors: Lisa S. Yospur, Nora C.J. Sun, Priscilla Figueroa, Yutaka Niihara
Journal: American Journal of Hematology (1996)

Immune thrombocytopenic purpura (ITP) and thrombotic thrombocytopenic purpura (TTP) have each been associated with HIV infection. Sequential occurrence of these two diseases with a disease-free interval has been occasionally reported in the literature, whereas simultaneous manifestations of these two diseases have not been described. Here, we report an AIDS patient who was initially diagnosed as having TTP and showed an apparent partial response to plasmapheresis but was found to have a clinical course similar to ITP. Although precise mechanisms for the development of TTP and ITP in these patients are unclear, we offer several hypotheses. It is important to recognize that these two processes may be seen concurrently. © 1996 Wiley-Liss, Inc.
Medicolegal Rounds
Authors: Richard P. Bergen
Journal: JAMA (1974)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Manual of Surgery for Students and Graduates.
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Recall of Drinking Patterns
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Commentary: Environmental Health Sciences Education. A Tool for Achieving Environmental Equity and Protecting Children
Authors: Luz Claudio, Teresa Torres, Eva Sanjurjo, Lloyd R. Sherman, Philip J. Landrigan
Journal: Environmental Health Perspectives (1998)

Children are highly susceptible to deleterious effects of environmental toxins.Those who live in underserved communities may be particularly at risk because environmental pollution has been found to be disproportionately distributed among communities.Mounting evidence suggests that asthma rates are rising and that this disease can be caused or aggravated by air pollution.Although ambient air quality has generally improved, these improvements have not reached minority communities in equal proportions.This and other data has fueled the concept of environmental justice or environmental equity, which has led to community activism and government actions.One possible example of environmental inequity and its consequences is the Hunt's Point community, in the South Bronx, New York.This community experiences a high pollution burden with the siting of facilities that emit hazardous wastes into the air.Our approach to this problem has been the formation of mechanisms for bidirectional communication between community residents, government entities, and academic institutions such as Mount Sinai Medical Center.As a result of this experience, we believe that the key to achieving environmental health, especially in communities of color where many children are at risk, is to empower residents to take charge of their environment by providing relevant educational opportunities.Strategies for environmental health education include multitiered training approaches that include community residents, parent education, direct children education, and community education through professional counselors and train-the-trainer approaches.We propose that academic researchers must use community residents not just as subjects of our studies, but to increase our mutual understanding of environmental health, resulting in active participation of community members in research design, data collection, analysis, and dissemination of results in order to make intervention strategies more effective.
at a glance..: one-minute abstracts of the literature on leukemia
Journal: CA A Cancer Journal for Clinicians (1959)

Chemotherapy of Acute LeukemiaSixty-five patients with acute leukemia were allocated at randoni to two combina tion cheniotherapeutic regimens.All pa tients were given 6-mercaptopurine 3 mg.per Kg.daily.One group was given in ad dition 2.5 mg.methotrexate daily and the other group 7.5 mg.methotrexate every three days.No differences in frequency of remission, extent of remission or toxicity were observed between the two groups.Remissions occurred only in children with acute lymphocytic leukemia and in adults with acute myelocytic leukemia.Remis sions in adults were longer than those in children.Remission, partial or complete, occurred in 36 per cent of the children and in 19 per cent of the adults.There were 17 deaths, eight in the first 10 days pre sumably froni leukemia and not drug tox icity.Five patients died with hypoplastic marrows ascribed to drug toxicity.The mean survival time from onset of symp toms for all the children was 12 months; for adults, seven months.This figure is similar to that reported from other clinics, showing that the patients were not harmed by these studies.
Effects of Temperature and Air Pollutants on Cardiovascular and Respiratory Diseases for Males and Females Older Than 65 Years of Age in Tokyo, July and August 1980-1995
Authors: Frank Ye, Warren T. Piver, Mitsuru Ando, Christopher J. Portier
Journal: Environmental Health Perspectives (2001)

We studied exposures to higher daily maximum temperatures and concentrations of air pollutants in Tokyo during the summer months of July and August from 1980 to 1995 and their effects on hospital emergency transports for cardiovascular and respiratory diseases for males and females > 65 years of age. Cardiovascular diseases were angina, cardiac insufficiency, hypertension, and myocardial infarction. Respiratory diseases were asthma, acute and chronic bronchitis, and pneumonia. Except for pneumonia, daily maximum temperatures were not associated with hospital emergency transports. Increasing daily maximum temperatures, however, were associated with decreased hospital emergency transports for hypertension. Concentrations of nitrogen dioxide or particulate matter < or = 10 microm, however, were associated with daily hospital emergency transports for angina, cardiac insufficiency, myocardial infarction, asthma, acute and chronic bronchitis, and pneumonia. For cardiac insufficiency, hypertension, myocardial infarction, asthma, chronic bronchitis, and pneumonia, the expected daily number of emergency transports per million were greater for males than for females. For angina and acute bronchitis, there were no differences for the expected daily numbers of emergency transports per million between males and females.
Poster Discussions
Authors: P. Siebenlist, R. Klobe, W. Gattenlöhner, A. N. Djugehev, V. F. Kovalev, M. D. Fomin, V. A. Sokolov, E. I. Vereschagin, T. Kasai, S. Endo, K. Inada, T. Takakuwa, Y. Yamada, T. Suzuki, S. Taniguchi, C. Hamilton-Davies, A. R. Webb, X. H. T. Wehrens, E. Lutgens, H. A. J. M. Kurvers, M. G. A. oude Egbrink, D. W. Slaaf, R. S. Reneman, P. J. E. H. M. Kitslaar, M. J. A. P. Daemen, G. Ramsay
Journal: Intensive Care Medicine (1996)
Looking at Cancer
Authors: J Barlow
Journal: CA A Cancer Journal for Clinicians (1973)

Commentary on the a compelling study in which 24 women with advanced cervi August1973(Volume .28, Number8)issue calcancerunderwentaortic lymph nodebiopsy, and in23 of them the histologic results confirmed the lymphangiographic findirtgs.They suggest that without lymphangiography, a A.Raventos, M.D. substantial number ofpatients withhighstage pelvic cancer Associate Editor would nothavethefull extent oftheir tumortreated.Unfor tunately, data is not now available to show whether or not treatment of para-aortic metastases is effective.Some au thorities interpret the finding of positive nodes as indication for radical surgical or radiation therapy, and others consider it an indication to retreat to minimal palliative measures.Several studies of pulmonary function after mantle field ir radiation in Hodgkin â€˜¿ s disease have demonstrated serious damage to the irradiated lungs.Examination of multiple parameters in 17 patients, by H. Host and J. R. Vale (Norwe gian Radium Hospital, Oslo, Norway) indicated that ventila tory impairment can be quite low if the pulmonary paren chyma is effectively shielded during the radiation.Adriamycin is a very effective but toxic cancer chemo therapeutic agent.E. A. Lefrak and others (Baylor College of Medicine, Houston, Texas) studied the cardiotoxic effects of adriamycin in 399 patients.Eleven patients developed severe congestive heart failure, which was fatal to eight of them.The mechanism appeared to be a diffuse myocar diopathy, with a striking decrease in the number of cardiac muscle cells and degeneration of those remaining.They cor relate the complication with dose of the drug and suggest that the total dose of adriamycin should be limited to less than 550 mg./m2 to permit safe use.Chordomas are tumors noted for their long but inexorable course.M. J. Heffelfinger and others (Mayo Clinic, Roches ter, Minnesota) have assembled an unusually large series of 155 chordoma cases.Among other observations they note that surgical intervention appeared to be most important in prolonging useful survival, but that many tumors also
Urinary Hexagons
Authors: Leonard B. Berman
Journal: JAMA (1974)

CYSTINURIA is an uncommon, easily diagnosable, and treatable disease. The latter two points make it a matter of interest to the practicing physician. We may define the disorder from the point of view of the nephron and from that of the patient. Present concepts hold that a congenital defect of kidney function prevents proper reabsorption by the proximal tubular epithelium of cystine, lysine, ornithine, and arginine. The solubility of cystine is such that crystallization and stone formation may occur. Other nephron functions, such as glomerular filtration, tubular reabsorption, and secretion of various solutes are intact. Clinically, a young person is seen with recurrent, radiopaque stones and no other problems. The diagnosis may be made in several ways, including microscopic examination of urine. It is this point whence the title of this discussion takes its name. Cystine crystals are hexagonal. Virtually<i>no other urine crystal is so shaped</i>. Second, crystals are
Ernst Kretschmer (1888-1964) body and mind
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Negative Chemical Ionization of Alcohols
Authors: R. Houriet, D. Stahl, F. J. Winkler
Journal: Environmental Health Perspectives (1980)

Reactions of the oxygen radical anion at low pressure (ICR conditions) with aliphatic alcohols are seen to give a limited number of product anions which allows for unambiguous determination of the structure of the neutral. The reactions of OH- are also investigated and mechanisms of reactions are discussed. Analytical application of NCI is also considered. OH- negative chemical ionization mass spectra, negative metastable ion spectra, and negative collisional activation spectra (negative product from negative precursor ions) have been applied to stereochemical problems of cyclic diols. The spectra of the cis and trans isomers of 1,3- and 1,4-cyclohexanediols and 1,2- cyclopentanediols show substantial and characteristic differences. The (M-H)- alkoxide anions produced by OH- reagent ions are stabilized for the cis isomers by formation of an intramolecular hydrogen bridge involving both oxygen functions. However, trans geometry of the (M-H)- ions is indicated by abundant (M-H3)- and/or (M-H-H2O) fragment ions. The stereospecificity increases with ion internal energy (high temperature, collisional activation) or especially with ion life times (metastable ions). It is shown that in F- negative chemical ionization the relative intensities of the fluoride attachment ions MF- and of the proton abstraction ions (M-H)- reflect the stereochemistry of the cyclic diols. The results demonstrate the potential of negative ion mass spectrometry for stereochemical investigations.
The spleen in immune thrombocytopenia
Authors: Julia T. Geyer, James B. Bussel
Journal: HemaSphere (2018)

1Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY 2Department of Pediatrics, Division of Hematology/Oncology, Weill Cornell Medicine, New York, NY, USA This is an open access Abstract Book distributed under the Attribution-NonCommercial-NoDerivs (CCBY-NC-ND), which allows third parties to download the abstracts and share them with others as long as they credit the author and the abstract book, but they cannot change the content in any way or use them commercially. http://creativecommons.org/licenses/by-nc-nd/4.0