tbuckley/cabot-search huggingface dataset:
Abstract 121: Cellular Origins of Postnatal Cardiomyogenesis in the Normal, Infarcted and Cell-Treated Heart
Authors: Konstantinos Malliaras, Eduardo Marbán
Journal: Circulation Research (2013)

Background: Controversy surrounds the putative mechanisms of cardiomyocyte (CM) replenishment in adult mammals. Using genetic fate mapping and bone marrow allotransplantation, we investigated the postnatal origins of CMs in the normal, infarcted and cell-treated heart. Methods &amp; Results: Tamoxifen pulsing of non-infarcted bitransgenic MerCreMer-ZEG mice (αMHC promoter driving inducible Cre) resulted in specific labeling of CMs by GFP. Comparison of BrdU incorporation (after 5 weeks of BrdU administration) in GFP+ and GFP- CMs (by flow cytometry, immunocytochemistry and histology) indicated that in the normal adult mouse heart, CM turnover occurs predominantly through proliferation of resident small mononucleated CMs at an annual rate of ~1.3%, independent from CM polyploidization, multinucleation, cell fusion or DNA repair. After myocardial infarction (MI), new CM formation in the border zone arises from both progenitor cells (PCs) as well as pre-existing CMs. Transplantation of cardiosphere-derived cells (CDCs) upregulates both host CM cycling and recruitment of PCs. To investigate the identity of endogenous PCs, bitransgenic mice underwent MI, followed by tamoxifen pulsing. One week later, FACS of myocyte-depleted hearts resulted in isolation of small non-myocyte GFP+ cells, which exhibit activated αMHC post-MI (~1.5% of cells in risk area vs &lt;0.2% in sham controls). These novel PCs (Sca1+ [53%]/ nestin+ [11%]/ ckit-/ ABCG2-) express cardiac transcription factors (Nkx 2.5, GATA4, MEF2C, FOXC2), cardiogenic molecules (BMP2) and cardiac structural proteins (at both transcript &amp; protein level), beat spontaneously in vitro and form CMs when injected into recipient hearts. Bone marrow transplantation demonstrated that recruited PCs do not arise from hematogenous seeding. Cell therapy with CDCs stimulates recruitment of PCs (~4.2% of cells in risk area), while improving heart function and increasing viable myocardium. Conclusions: The normal adult mouse heart replenishes lost CMs through proliferation of pre-existing CMs. After MI, proliferation of resident CMs increases, but new CMs also arise from recruited PCs. CDCs boost both CM proliferation as well as recruitment of endogenous PCs, resulting in myocardial regeneration.
Screening Procedures in the Asymptomatic Adult
Authors: Barbara Woo
Journal: JAMA (1985)

To assess attitudes and practices regarding screening tests and preventive procedures, we surveyed 83 physicians in a hospital-based ambulatory care practice and compared their recommendations with the recommendations in published guidelines, the desires of 188 of their own patients, and the physicians' actual practice patterns on the surveyed patients. The surveyed physicians recommended screening procedures more frequently than the published guidelines in 48 situations and less frequently in 18 situations. Physicians at earlier levels of training tended to recommend more procedures than those who had completed training. Patients desired far more frequent screening than recommended either by their physicians or by the published guidelines. Physicians did not live up to their own recommendations for four of 14 procedures or to published guidelines for five of 14 procedures, with such failure occurring principally in situations where the test or procedure would normally be done personally by the physician. (<i>JAMA</i>1985;254:1480-1484)
Association Between Altitude and Mortality in Incident Dialysis Patients
Authors: Stanley Shaldon
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Orotracheal Intubation
Authors: Marie Godet
Journal: New England Journal of Medicine (2010)

The advantages of endotracheal intubations are many: patency of airway is reasonably assured, secretions may be removed easily from the tracheobronchial tree, the airway is better protected against aspiration, ventilation can be regulated, and drugs can be administered. The procedure is the "gold standard" of airway control, and the oral route is the most common used. The patient is assessed for potential difficulties that may arise from abnormalities of face and mouth: large face, large tongue, hypoplastic mandible, prominent or diseased maxillary teeth or facial fractures; or abnormalities of the neck: potential or real cervical spine instability, swelling, or laryngeal trauma. A plan is devised, together with one or more alternatives, should unforeseen difficulties arise, and in adherence to the principle of never removing the compensations of a coping patient. The skill is learned and practiced so that a gentle facility is always present at times of greatest need.
Natural Science
Authors: Lewis Thomas
Journal: New England Journal of Medicine (1973)

THE essential wildness of science as a manifestation of human behavior is not generally perceived. As we extract new things of value from it, we also keep discovering parts of the activity that seem in need of better control, more efficiency, less unpredictability. We'd like to pay less for it and get our money's worth on some more orderly, businesslike schedule. The Washington planners are trying to be helpful in this, and there are new programs for the centralized organization of science all over the place, especially in the biomedical field.It needs thinking about. There is an almost ungovernable, . . .
THE ATONIC ABDOMINAL WALL
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pertussis vaccine injury. AMA Ad Hoc Panel on Pertussis Vaccine Injury
Journal: JAMA (1985)

An ad hoc panel of the American Medical Association prepared a report to identify severe, irreversible pertussis vaccine reactions and to establish criteria for attributing such reactions to the vaccine. Severe but reversible reactions, their likely duration and effects, and the clinical criteria for attribution were also examined. Three types of reactions which may produce residual brain damage lasting more than one year are encephalopathy, complex febrile convulsions, and afebrile convulsions. Serious pertussis vaccine reactions which are unlikely to have persistent adverse effects are simple febrile convulsions, anaphylaxis, and shock collapse. The panel also noted that there is no evidence that killed vaccine such as the pertussis vaccine can cause any insidious, delayed harmful effects.
Chemotherapy's negative aspects: whose concern?
Journal: JAMA (1980)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
First International Symposium on Primary Prevention and Cancer
Journal: JNCI Journal of the National Cancer Institute (1986)

Journal Article First International Symposium on Primary Prevention and Cancer Get access JNCI: Journal of the National Cancer Institute, Volume 76, Issue 1, January 1986, Page 165, https://doi.org/10.1093/jnci/76.1.165 Published: 01 January 1986
New Schizophrenia Treatment; No Significant Improvement
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The search for a magic bullet to fight sepsis
Authors: R. C. Bone
Journal: JAMA (1993)

Recently, excitement among the clinical researchers trying to identify additional treatments for sepsis and its associated disorders reached a fever pitch after the publication of two controlled, multicenter clinical trials of monoclonal antibodies against endotoxin. The results of these trials indicated that these antibodies could improve survival in some subgroups of patients suspected of having gram-negative sepsis.<sup>1,2</sup> See also p 2221. These trials followed an earlier study that showed that antisera from volunteers injected with the J5<i>Escherichia coli</i>mutant could improve survival in patients with gram-negative sepsis.<sup>3</sup>Because of these studies, it was widely perceived that Food and Drug Administration approval of one or both of these antibodies would be imminent following publication of the controlled clinical trial results. Clinicians and clinical investigators attempted to develop guidelines for the appropriate use of these therapies—albeit among patients most likely to benefit—so that if approved, they would be used
Collision with spring-loaded football tackling and blocking dummies. Report of near-fetal and fatal injuries
Authors: J. S. Torg
Journal: JAMA (1976)

APPROXIMATELY 1,200,000 individuals participate in organized tackle football in this country each fall. Recent reports place the incidence of time-loss injury from this vigorous contact sport at 50% to 86% of the population at risk per season.<sup>1,2</sup>Fatality rates have averaged two per 100,000 participants per year for direct causes over a 43-year period.<sup>3</sup>Of the fatalities due to direct causes, the overwhelming majority have been due to head and neck injuries. Schneider<sup>4</sup>has described a variety of mechanisms responsible for near-fatal and fatal head and neck injuries. These include knee-to-head injuries, tackling by face mask, hyperflexion injuries secondary to spearing and buttblocking, and hyperextension injuries of the cervical spine due to the levering effect of the face mask. The purpose of this communication is to describe a cause of near-fatal and fatal head and neck injury, to our knowledge previously unreported: collision with spring-loaded blocking and
Comparison of Screening Mammography in the United States and the United Kingdom
Authors: Renke Maas, Rainer Bo ¨ger, Edzard Schwedhelm, Juan Casas, Patricio Lo ´pez-Jaramillo, Norma Serrano, Luis Dı ´az
Journal: JAMA (2004)

mester at delivery), severity of pre-eclampsia, gestational age at delivery, and birth weight (Table 1) were comparable with those from previous studies from Western Europe. 2,3,5In light of the lack of ethnicity-related differences in ADMA concentrations in our sample, ethnicity does not appear to explain our results.Thus, our results support the hypothesis that preeclampsia in low-and high-risk populations may have distinct underlying causes.
Testing for Nondisjunction in the Mouse
Authors: Ann C. Chandley, R. M. Speed
Journal: Environmental Health Perspectives (1979)

Tests for nondisjunction have been carried out in male and female mice. Ten-day fetal progeny of control and treated adults have been karyotyped to establish spontaneous and induced levels of aneuploidy. In males, the effects of 100 rad x-rays on type A spermatogonia and early primary spermatocytes, and the effects of Mitomycin C (2 mg/kg) on early primary spermatocytes, have been tested. The results show insensitivity of primary spermatocytes to both agents, but a 3.5-fold increase in nondisjunction following spermatogonial irradiation. In females, comparisons have been made between young controls, young x-rayed (5 rad), aged controls and aged x-rayed (5 rad) animals. The "ageing effect" on nondisjunction is observed, but too few fetuses have been analyzed to reach conclusions regarding enhancement of nondisjunction levels by low doses of x-rays.
SOCS1 Cooperates with FLT3-ITD In the Development of Myeloproliferative Disease by Promoting the Escape From External Cytokine Control.
Authors: Christian H. Brandts, Pavankumar Reddy, Bülent Sargin, Chunaram Choudhary, Carsten Muller-Tidow, Wolfgang E. Berdel, Hubert Serve
Journal: Blood (2010)
The pink vans: Bringing cancer screening closer to home.
Authors: Frederic Ivan Leong Ting, Louis Mervyn Banua Leones, Abigail Sy Chan, Jorge Garcia Ignacio
Journal: Journal of Clinical Oncology (2020)

e14021 Background: A global survey reported that among 15 Asian countries, the Philippines has the highest breast cancer mortality rate and the lowest mortality-to-incidence ratio. This may be due to the fact that majority of breast cancers are diagnosed in locally advanced or metastatic stages among low- and middle-income countries. Studies show that in the Philippines more than half (53%) of patients with breast cancer were diagnosed at stages III and IV, while only 2-3% of cases were treated at Stage I. This translates to a dismal 58.6 % 5-year survival rate. Furthermore, socioeconomic factors were identified as one of the major causes for the lack of access to early detection and treatment. These include lower educational level, higher poverty rates, inadequate or no health insurance, lack of transportation, and/or the unavailability of health services in far-flung areas. These findings are currently of urgent national concern since the improvements in breast cancer survival rates brought by advances in treatments are mainly dependent on early detection, screening and timely treatment. Methods: In response to this gap in the delivery of services to promote early cancer detection, the University of the Philippines – Philippine General Hospital (UP-PGH) Cancer Institute established the Mobile Breast Cancer Diagnostic Clinic Program, a first in the country where two fully equipped “pink” vans are sent out to far flung areas and provide breast cancer screening and diagnostic services (eg. Mammogram, breast ultrasound, biopsies of suspicious masses, etc). These vans are manned by medical and surgical oncologists, and various paramedical professionals. Results: In the first 6 months of the program, the “pink” vans were able to visit 3 strategically identified areas in the country. These three tours have served a total of 189 women who all underwent screening mammography. 18 had their suspicious lesions biopsied, and two-thirds of which were found to be malignant. These patients were then referred to our institution for further work-up and management. Conclusions: As the Philippine health department continues to emphasize clinical and self-breast exam as part of its breast cancer control program, efforts like the UP-PGH “Pink Vans” may eventually help supplement the gap in the country’s breast cancer screening endeavors with the goal of improving survival by identifying the disease at its earliest stage.
Blood Lead Levels of Primary School Children in Dhaka, Bangladesh
Authors: Reinhard Kaiser, Alden K. Henderson, W. Randolph Daley, Mary Naughton, Manzurul H. Khan, Mushior Rahman, Stephanie Kieszak, Carol H. Rubin
Journal: Environmental Health Perspectives (2001)

Dhaka, Bangladesh, has one of the highest air lead levels in the world. In February 2000, we evaluated children at five primary schools in Dhaka to determine blood lead (BPb) levels, sources of environmental exposure, and potential risk factors for lead poisoning. Selected schools represented a range of geographic and socioeconomic strata. A total of 779 students 4-12 years of age participated. The mean BPb level was 15.0 microg/dL (range 4.2-63.1 microg/dL). Most students (87.4%) had BPb levels above the Centers for Disease Control and Prevention's level of concern (10 microg/dL). Elevated BPb levels correlated with soil eating [odds ratio (OR) = 3.31; 95% confidence interval (CI), 1.30-8.39], low parental education (OR = 2.72; 95% CI, 1.97-3.75), living close to major roads (OR = 2.30; 95% CI, 1.23-4.29), and increasing age (OR = 1.11; 95% CI, 1.06-1.16). BPb levels measured were similar to those in other countries that use leaded gasoline. No other potential sources of lead exposure were consistently identified. Combustion of leaded gasoline is the main source of lead exposure in Dhaka, resulting in ubiquitous contamination of the environment. The increase in BPb levels with age, a finding contrary to observations in the United States and Australia, may be related to increased outdoor activities. The Bangladeshi government recently announced a plan to eliminate leaded gasoline. Baseline BPb surveys are critical to develop and evaluate intervention policies. Strategies to reduce BPb levels need to address variations in socioeconomic status, construction type and location of housing, and levels of hygiene.
GROUP PRACTICE; DIAGNOSTIC AND PAY CLINICS
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal