tbuckley/cabot-search huggingface dataset:
In Reply
Authors: S. Yousuf Zafar, Amy P. Abernethy, David Currow
Journal: Journal of Clinical Oncology (2009)

THE EDITOR: In addition to the problems with such studies as discussed by Zafar et al, 1 another surprisingly unaddressed issue is the frequency of patient visits by health care professionals.In the panitumumab versus best supportive care (BSC) studies, 2,3 patients who received the drug were presumably seen by health care professionals every 2 weeks at the time of drug delivery, whereas those receiving only BSC were assessed, perhaps only, radiographically every 4 or even 8 weeks.In the cetuximab study, 4 the differences in frequency of visits were even greater, with the treated group seen weekly and the BSC group seen every 4 weeks.This may result in the treated group having a shorter progressionfree survival because of earlier recognition of disease progression.On the other hand, complications and problems can be noted and addressed earlier in the treated group, possibly prolonging time on treatment, progression-free survival, and altering overall survival.In the future, such studies should consider having patients seen with the same frequency in both the treatment and BSC arms.Given that the overall survival differences were either not significant 3 or perhaps not clinically meaningful, 4 especially given the cost of the treatment, collecting the data in such a manner may have led to results different from those obtained.
Erratum for the Research Article: “Two recombinant human monoclonal antibodies that protect against lethal Andes hantavirus infection in vivo” by J. L. Garrido, J. Presscott, M. Calvo, F. Bravo, R. Alvarez, A. Salas, R. Riquelme, M. L. Rioseco, B. N. Williamson, E. Haddock, H. Feldmann, M. I. Barria
Journal: Science Translational Medicine (2019)
Radiological Observations in Acute Ureteral Obstruction
Journal: JAMA (1963)

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Brodalumab 用于对乌司奴单抗应答不足的患者
Authors: R.G. Langley, A.W. Armstrongi, M.G. Lebwohl, A. Blauvelt, S. Hsu, S. Tyring, S. Rastogi, R. Pillai, R. Israel
Journal: British Journal of Dermatology (2019)

银屑病是一种慢性病,可导致皮肤表面出现红色、鳞状斑点。治疗方法包括局部用(涂抹于皮肤上)乳膏、口服药物和注射用药物。银屑病由一种自身免疫反应所引起,自身免疫反应是指身体自己的免疫系统攻击健康的细胞和组织。为了治疗中度至重度银屑病,医生有时会使用名为抗体的特异性药物,抗体药物可阻断导致银屑病的自身免疫反应作用于身体不同部位。虽然这类抗体治疗有可能非常有效,但并不能对所有患者都有作用。本研究回顾了两项针对中度至重度银屑病患者的临床研究得出的数据。在每项研究中,患者最初接受以下两种抗体治疗之一:乌司奴单抗或 Brodalumab。有些最初接受乌司奴单抗或 Brodalumab 治疗的患者在第 16 周时的皮肤病变清除率不达标;这些患者或者开始使用 Brodalumab(如果他们最初接受乌司奴单抗治疗),或者继续使用 Brodalumab(如果他们最初接受 Brodalumab 治疗),直至第 52 周。第 16 周后对初始治疗应答不足的患者继续接受初始治疗,直至第 52 周。第 52 周时,因对乌司奴单抗应答不足而改用 Brodalumab 的患者表现出皮肤病变清除率提高。对于第 16 周后出现应答不足并继续使用乌司奴单抗的患者,其皮肤病变清除的彻底性不如第 16 周时因应答不足而改用 Brodalumab 的患者。此外,改用 Brodalumab 的患者和继续使用乌司奴单抗的患者出现的副作用相似。本研究的结果表明,对于使用其他银屑病疗法达不到足够皮肤病变清除率的中度至重度银屑病患者,Brodalumab 可能会表现出良好的疗效。
Intravenous administration of follistatin: Delivery to the liver and effect on liver regeneration after partial hepatectomy
Authors: K Kogure
Journal: Hepatology (1996)

When 1 μg 125I-follistatin was administered into a rat intravenously, radioactivity levels in serum decreased rapidly. Analysis with a biexponential equation showed that the initial half- life and the terminal half-life were 4.0 and 130.8 minutes, respectively. After 2 hours of infusion, approximately 9% of the follistatin infused remained in the liver, which was much more than that in kidney, spleen, pancreas, intestine, or lung. Autoradiography of the liver obtained at 24 hours of infusion revealed that numerous grains were located in parenchymal cells. Radioactivity of 125I- follistatin in the liver remained elevated until 72 hours and declined markedly thereafter. When a booster shot of 125I-follistatin was administered at 72 hours, radioactivity in the liver at 120 hours was markedly increased compared with that in rats that received a single shot of 125I-follistatin. We then examined the effect of intravenous infusion of follistatin on liver regeneration after hepatectomy of 70%. Immediately after the hepatectomy, either 1 microgram follistatin or saline was infused intravenously. In some rats, a booster shot was infused at 72 hours. After 120 hours of hepatectomy of 70%, remnant liver weight, liver regeneration rate, and DNA content were significantly (P < .05) higher in rats that received a booster shot of follistatin at 72 hours than those in control rats. These results indicate that follistatin administered intravenously accumulates in the liver and promotes liver regeneration after partial hepatectomy.
Anticoagulation: A contraindication to intrauterine-device insertion
Authors: L. E. Knight
Journal: JAMA (1978)

THROMBOPHLEBITIS in an otherwise healthy woman using oral contraceptives calls for change in the method of contraception. The usual method of choice would be the intrauterine device (IUD). Of two recent articles listing instances in which the use of an IUD would be proscribed,<sup>1,2</sup>neither mentioned the current use of anticoagulants. We suggest that anticoagulation may be a contraindication to IUD insertion. <h3>Report of a Case</h3> A 20-year-old woman (gravida 0) who was taking birth control pills for three years experienced a spontaneous episode of thrombophlebitis in the right leg. She was hospitalized and treated with heparin sodium and antibiotics. When discharged from the hospital, she was instructed to take warfarin sodium, 5 mg/day. The patient came in for IUD insertion on the second day of her menses. After a routine bimanual examination, the uterus was sounded to ascertain the depth of the cavity, and a copper-wrapped IUD was
TUBERCULOSIS OF RABBITS INDUCED BY DROPLET NUCLEI INFECTION
Authors: H. L. Ratcliffe, W. F. Wells
Journal: The Journal of Experimental Medicine (1948)

Rabbits were caused to inhale known numbers of virulent bovine tubercle bacilli as separated cells in droplet nuclei. For approximately 5 weeks after infection the growth of the bacilli and the response of rabbits to their growth was homogeneous; i.e., all reacted in the same way and to the same degree. After 6 weeks individual differences in the rate of progress of the initial tubercles and of the infection as a whole became evident. These variations in the response seemed to be influenced by the number of initial tubercles and by the number of bacilli found in the lesions. It is concluded that, as evidenced by the homogeneous phase of infection, rabbits do not differ in their resistance to initial growth of bovine tubercle bacilli. However, the later, heterogeneous pattern of response suggests that these animals vary widely in their capacity to acquire resistance.
RELIEF FOR THE TYROLESE
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Role of the laboratory in the diagnosis of anemia
Authors: R. O. Wallerstein
Journal: JAMA (1976)

ANEMIA is a common clinical finding that can be assessed by a systematic use of the laboratory. More than 30 tests dealing directly with the cause of anemia are available in good hospital laboratories (Table). Problems with anemia can usually be solved by a few judiciously selected procedures. The tests can be separated into screening and specific classifications (Table). The screening tests can establish the category in which the anemia belongs, and the specific tests enable further study of the anemia in that category. It is convenient to begin the workup by considering the four categories of anemia: (1) iron deficiency, (2) megaloblastic, (3) hemolytic, and (4) bone-marrow failure, which has four subcategories—absolute (eg, aplastic anemia, leukemia, myeloma), relative (anemia associated with chronic disease, eg, infection, azotemia, liver diseases), ineffective erythropoiesis (ie, intramedullary hemolysis or refractory normoblastic anemia), and pure red blood cell (RBC) anemia. The most common anemias are
Confounded Caps
Authors: Robert Hawkins
Journal: JAMA (1974)

<h3>To the Editor.—</h3> The latest in the savior-rebuffing syndrome is the patient response to the kiddy-proof pill bottles. More than one patient has confided to me that, when confronted by one of these confounded caps, he does the same thing he did 30 years ago when handed a machine-capped drink: hands it back and asks to have the cap removed. Then, he takes it home<i>with the cap loose!</i>This solves the problem with cumbersome caps of all types, but it introduces a new one. Medication that may be damaged by humidity will be damaged to some extent if not tightly capped. Perhaps we could revive the skull and crossbones for "external use only" preparations, as well as for toxic and caustic compounds of all types. I would suggest a red skull and crossbones for the purposes originally intended. In addition, a second, green skull and crossbones would mean "use
Richard Powell (1767-1834)
Journal: JAMA (1969)

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Spring
Authors: M. Therese Southgate
Journal: JAMA (2000)

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Evaluation of routine ECG screening of an outpatient population with computer diagnoses
Authors: A. Fieldman
Journal: JAMA (1968)

A study was performed at the Hartford Hospital to determine the value of routine screening electrocardiography in an outpatient population. Screening electrocardiograms were abnormal in 1,197 of 2,924 cases (40.9%). Dependence upon physician request or upon a positive response to a cardiovascular questionnaire resulted in the exclusion of almost one half of presumably unsuspected abnormalities. In a few clinics, the screening yield of abnormality approached the yield resulting from ECGs requested by physicians. In others, in the face of a virtual lack of requested ECGs, there was a significant frequency of screening abnormalities. Screening electrocardiography produced a yield of abnormality sufficient for it to be recommended as a regular hospital procedure. Interpretation of ECGs and compilation of statistical data were performed by automated methods, with the use of computer analysis.
Psychiatric and Psychological Aspects in Rehabilitation of Patients with Congenital Malformations Associated with Thalidomide
Journal: JAMA (1963)

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Miscellanea Medica
Journal: JAMA (1992)

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Autologous blood transfusion is more cost effective than allogenic transfusion
Journal: BMJ (2002)

Some caution is needed in interpreting Cochrane reviewsCochrane reviews contain methodological and other weaknesses, in particular the over-rating by the reviewers in their conclusions of the benefits of new interventions.Olsen and colleagues (p 829) assessed the quality of a sample of 53 reviews first published in the Cochrane Library in 1998 and found major problems in 15.The evidence did not fully support the conclusion in nine reviews, the conduct or reporting was unsatisfactory in 12, and stylistic problems (such as errors in spelling or grammar) occurred in 12.The authors say that although the Cochrane Library remains a key source of evidence on the effects of health interventions, the reviews should be interpreted cautiously.
Early HIV Detection Is Goal of Updated Testing Guidelines
Journal: JAMA (2014)

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ITALY
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
2011 ASA/ACCF/AHA/AANN/AANS/ACR/ASNR/CNS/SAIP/SCAI/SIR/SNIS/SVM/SVS Guideline on the Management of Patients With Extracranial Carotid and Vertebral Artery Disease
Authors: Thomas G. Brott, Jonathan L. Halperin, Suhny Abbara, J. Michael Bacharach, John D. Barr, Ruth L. Bush, Christopher U. Cates, Mark A. Creager, Susan B. Fowler, Gary Friday, Vicki S. Hertzberg, E. Bruce McIff, Wesley S. Moore, Peter D. Panagos, Thomas S. Riles, Robert H. Rosenwasser, Allen J. Taylor
Journal: Circulation (2011)
Update: HIV-2 Infection Among Blood and Plasma Donors—United States, June 1992-June 1995
Journal: JAMA (1995)

Human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) both cause acquired immunodeficiency syndrome (AIDS). Following the licensure of combination HIV-1/HIV-2 screening enzyme immunoassays (EIA), the Food and Drug Administration (FDA) recommended that beginning in June 1992 all donated whole blood, blood components, and source plasma be screened for antibody to HIV-2 because not all persons infected with HIV-2 can be detected by HIV-1 testing (1,2). This report describes the first two cases of HIV-2 infection detected among potential blood donors since the implementation of recommended HIV-2 screening and summarizes national data about persons known to be infected with HIV-2 during December 1987-June 1995.