tbuckley/cabot-search huggingface dataset:
Is syncope related to moderate altitude exposure?
Authors: R. Nicholas
Journal: JAMA (1992)

<h3>Study Objective.</h3> —To investigate factors related to syncope occurring on recent ascent to moderate altitude. <h3>Design.</h3> —A 1-year retrospective case-control study, using local acclimatized residents as a control group. <h3>Setting.</h3> —The two main ambulance destinations for Summit County, Colorado (elevation, 2770 m). <h3>Patients.</h3> —All patients with a diagnosis of syncope, near-syncope, or fainting whose medical records were available for review. <h3>Results.</h3> —There was a significant relationship (<sup>P</sup>&lt;.05) between syncope of unknown origin and recent arrival at altitude (&lt;24 hours), and a significant inverse relationship (<i>P</i>&lt;.05) between syncope of unknown origin and arterial oxygen saturation as measured by pulse oximetry. <h3>Conclusions.</h3> —Short-term exposure to moderate altitude may be related to otherwise unexplained syncope in healthy young adults. We suggest the name<i>high-altitude syncope</i>for this entity and encourage further research in this area. (<i>JAMA</i>. 1992;268:904-906)
Wegener's granulomatosis. Successful treatment with chlorambucil
Authors: S. K. McIlvanie
Journal: JAMA (1966)

Regression of all lesions and relief of symptoms occurred in two patients with Wegener's granulomatosis treated with chlorambucil. One patient is living and well after 22 months of treatment and the other after 12 months. Both have shown a striking reversal of abnormal protein electrophoretic patterns. Therapy with chlorambucil has been continuous.
Lack of histological steatohepatitis features in advanced fibrosis could impact in screening failure rate: a comparison with FDA clinical criteria
Authors: Javier Ampuero, Rocío Aller, Rocío Gallego-Durán, Javier Crespo, José Luis Calleja Panero, Carmelo García-Monzón, Judith Gómez-Camarero, Juan Caballería, Oreste Lo Iacono, Rafael Bañares, Francisco Javier Garcia-Samaniego Rey, Agustin Albillos, Rubén Francés, Conrado Fernández- Rodríguez, Moises Diago, German Soriano, Raul J. Andrade, Raquel Latorre Martínez, Francisco Jorquera, Rosa Ma Morillas, Desamparados Escudero-García, Pamela Estevez, Manuel Hernandez-Guerra, Salvador Augustin, Jesus M. Banales, Patricia Aspichueta, Salvador Benlloch, Jose Miguel Rosales Zabal, Javier Salmerón, Juan Turnés, Manuel Romero Gomez
Journal: Journal of Hepatology (2020)
Pulmonary Hypertension in <i>Circulation</i> and the <i>Circulation</i> Subspecialty Journals
Journal: Circulation (2012)

The following articles are being highlighted as part of Circulation's Topic Review series. This series will summarize the most important manuscripts, as selected by the editors, published in Circulation and the Circulation subspecialty journals. The studies included in this article represent the articles related to pulmonary hypertension that were published in Circulation and the Circulation subspecialty journals in 2010 and 2011.
T030 (0103) BENDAMUSTINE, GEMCITABINE, AND DEXAMETHASONE (BGD) CHEMOTHERAPY FOLLOWED BY AUTOLOGOUS STEM CELL TRANSPLANTATION (ASCT) IS EFFECTIVE TREATMENT FOR PATIENTS WITH RELAPSED/REFRACTORY HODGKIN LYMPHOMA (RHL) – RESULTS OF THE POLISH LYMPHOMA RESEARCH GROUP (PLRG) PILOT STUDY – PRE‐PLRG‐HL1 (BURGUND)
Journal: HemaSphere (2018)
Resolution of psoriasis upon blockade of IL-15 biological activity in a xenograft mouse model
Authors: Louise S. Villadsen, Janine Schuurman, Frank Beurskens, Tomas N. Dam, Frederik Dagnæs-Hansen, Lone Skov, Jørgen Rygaard, Marleen M. Voorhorst-Ogink, Arnout F. Gerritsen, Marc A. van Dijk, Paul W.H.I. Parren, Ole Baadsgaard, Jan G.J. van de Winkel
Journal: Journal of Clinical Investigation (2003)

Psoriasis is a chronic inflammatory disease of the skin characterized by epidermal hyperplasia, dermal angiogenesis, infiltration of activated T cells, and increased cytokine levels. One of these cytokines, IL-15, triggers inflammatory cell recruitment, angiogenesis, and production of other inflammatory cytokines, including IFN-γ, TNF-α, and IL-17, which are all upregulated in psoriatic lesions. To investigate the role of IL-15 in psoriasis, we generated mAb's using human immunoglobulin-transgenic mice. One of the IL-15–specific antibodies we generated, 146B7, did not compete with IL-15 for binding to its receptor but potently interfered with the assembly of the IL-15 receptor α, β, γ complex. This antibody effectively blocked IL-15–induced T cell proliferation and monocyte TNF-α release in vitro. In a human psoriasis xenograft model, antibody 146B7 reduced the severity of psoriasis, as measured by epidermal thickness, grade of parakeratosis, and numbers of inflammatory cells and cycling keratinocytes. These results obtained with this IL-15–specific mAb support an important role for IL-15 in the pathogenesis of psoriasis.
PCLN-02. EVALUATING THE POWER OF PATIENT TUMOR-DERIVED ORTHOTOPIC XENOGRAFT (PDOX) MODELS OF PEDIATRIC BRAIN TUMORS TO PREDICT DRUG RESPONSES IN HUMANS
Authors: Sarah Injac, Yuchen Du, Mari Kogiso, Frank Braun, Huiyuan Zhang, Lin Qi, Holly Lindsay, Sibo Zhao, Xiao-nan Li
Journal: Neuro-Oncology (2018)

Brain tumors are the leading cause of cancer-related death in children. A major hurdle for clinical drug development is the lack of model systems that can accurately predict drug responses in human patients. To address this issue, our lab has established a large panel (>80) of orthotopic xenograft mouse models of brain tumors that have been shown to replicate the histopathological features phenotypes and gene expression profiles of the original primary tumors. In addition, treatment information and clinical outcomes are available for the patient’s from which these models were derived. To test whether these patient tumor-derived orthotopic xenograft tumor respond to anti-cancer therapies similarly to the corresponding human primary tumors, we designed treatment schedules based on original patient treatment data for 8 pediatric glioblastoma models, 9 medulloblastoma models, and 5 DIPG models and treated them accordingly. We are able to demonstrate the feasibility of combining radiation and multi-agent cytotoxic chemotherapy our mouse models. Furthermore, our results correlate with what has been seen in large scale human clinical trials with glioblastoma and DIPG models showing little benefit from standard treatments while medulloblastoma models show a significant increase in survival time.
American Review of Respiratory Diseases, New York
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Identification and Quantitation of Asbestos in Talc
Authors: Arthur N. Rohl, Arthur M. Langer
Journal: Environmental Health Perspectives (1974)

The currently used analytical methods for identification, characterization and quantitation of asbestos fiber in consumer talcum products include polarized light microscopy, x-ray diffraction analysis, transmission electron microscopy with selected area electron diffraction and electron microprobe techniques. Light microscope methods have severe limitations imposed by the ultimate size resolution of the light-optical system. Small particles go unresolved; those marginally resolved may possess optical properties different from those properties cited in the literature; most optical properties, e.g., indices of refraction, are difficult to measure on small particles. In addition to these difficulties, talc fibers often possess optical properties different from those of talc plates, which further confound analysis. Light microscopy is recommended for use only as a preliminary tool on limited, large-sized, samples. Transmission electron microscopy is a good standard technique for visualization of contaminant asbestos fibers. Together with selected area electron diffraction, talc fibers may be easily differentiated from amphibole asbestos fibers on the basis of both morphological and structural characterization. Chrysotile fibers are easily distinguished on this basis as well. The amphibole asbestos minerals require chemical characterization to differentiate among the different fiber types. Probe analysis is mandatory for such fibers. The major drawbacks to electron beam instrumentation for the mineralogical characterization of talcum products are the time and effort required for data acquisition. These techniques do not lend themselves to routine study. X-ray diffraction analysis, utilizing the step-scan method, offers a relatively rapid, quantitative technique for gross fiber analysis. Based on comparison with standard specimens the fiber content of talcs may be quantitatively determined. It is essential to employ a specimen preparation technique which yields homogeneously dispersed particles. Tremolite may be determined at levels as low as 0.10% by weight, chrysotile 0.25%, and anthophyllite at 2.0% by weight occurrence in talc. The variance of these values depends upon many factors, including the mass absorption coefficient of the fiber types as compared to talc and selected diagnostic reflections and their relative intensities. Each of the above techniques is described in detail. A method for routine analysis of consumer talcum products is suggested.
Announcement
Authors: Chiara Brombin, Ernesto Caffo, J. Wiltink, P. Bech, H.V. Hansen, L.V. Kessing, C. Faravelli, C. Ravaldi, E. Truglia, T. Zucchi, F. Cosci, V. Ricca, Johann F. Kinzl, Katharina Hauer, Christian Traweger, Ingrid Kiefer, Chiara Ruini, Carlotta Belaise, A. Dippel, M. Szczepanski, R. Thiede, Yi-Ching Lu, M.E. Beutel, Giovanni A. Fava, Silvana Grandi, Stefania Fabbri, Naike Panattoni, Elisabetta Gonnella, Isaac Marks, Nina Rieckmann, Matthew M. Burg, William Gerin, William F. Chaplin, Lynn Clemow, Karina W. Davidson, Johan Denollet, Jacqueline J. Strik, Richel Lousberg, Adriaan Honig, Bih-Ching Shu, Yong-Yuan Chang, For-Wey Lung, Boudewijn van Houdenhove, Victor I. Spoormaker, Jan van den Bout
Journal: Psychotherapy and Psychosomatics (2006)
Obstructive uropathy mimicking volume depletion
Authors: L. M. Hoffman
Journal: JAMA (1976)

WHEN volume depletion, heart failure, or other salt-retaining states occur, the reabsorption of sodium in the proximal and distal renal tubules is enhanced.<sup>1,2</sup>As a result, the urine is usually hyperosmotic to plasma, with a sodium concentration equal to or less than 10 to 15 mEq/liter.<sup>3</sup>Based on these facts, one laboratory criterion for volume depletion, or other prerenal factors, in the etiogenesis of acute oliguria is a low urinary sodium concentration.<sup>3</sup> The physicians managing two patients with acute urinary tract obstruction and low urinary sodium values were misled by laboratory values to an initial diagnosis of volume depletion. <h3>Report of Cases</h3><h3>Case 1.—</h3> An 82-year-old man who, during December 1970, fell and sustained a comminuted fracture of the left hip. A pin was inserted in the femur several days after the accident. At that time, a Foley catheter was inserted. On Jan 12,1971, the Foley catheter
Analysis of DPYD and UGT1A1 genotype in patients with advanced pancreatic cancer treated with modified FOLFIRINOX
Authors: C. Vivaldi, E. Arrigoni, R. Morganti, I. Pecora, L. Fidilio, S. Catanese, G. Restante, L. Fornaro, S. Crucitta, M. Lencioni, E. Rofi, E. Vasile, A. Falcone, R. Danesi, M. Del Re
Journal: Annals of Oncology (2017)
Researcher Traces Rare Disease Back to the 17th Century
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Surgical Therapies
Authors: C.-Y. Kim, M. Tate, E. Chang, M.-Y. Polley, M. Berger, L. Mercier, R. F. Del Maestro, K. Petrecca, D. L. Collins, F. Doglietto, F. Salehi, R. Ridout, F. Gentili, G. Zadeh, R. K. Shrivastava, M. Ghesani, C. Sen, R. K. Shrivastava, A. Tabaee, K. D. Lee, J. J. DePowell, E. Air, A. K. Dwivedi, C. M. McPherson, M. V. Mishra, D. Andrews, J. Evans, J. Glass, A. P. Dicker, Y. R. Lawrence, M. Kirsch, T. Juratli, K. Meyer, G. Schackert, J. M. Cho, E. H. Kim, M. C. Oh, J. H. Chang, S. H. Kim, K. S. Lee, J. M. Cho, E. H. Kim, M. C. Oh, J. H. Chang, S. H. Kim, K. S. Lee, H. Adams, J. Avendano, S. M. Raza, A. Olivi, A. Quinones-Hinojosa, R. F. Del Maestro, V. Siu, M. Seyed sadr, J. Alshami, C. Sabau, E. Seyed sadr, M. Anan, M.-C. Guiot, A. Samani, P. Del Maestro, A. Galameau, K. Greaves, J.-F. Pouliot, F. Mangano, D. Pruitt, T. Hummel
Journal: Neuro-Oncology (2010)
CAPE TOWN
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
U.S. trials show heroin not superior to morphine
Authors: B. Bolsen
Journal: JAMA (1982)

Contrary to its reputation as a uniquely effective analgesic used by British physicians to ease the pain of patients dying of cancer, heroin has emerged from clinical trials in the United States looking much like morphine, from which it is derived. Clinical comparisons of the two agents were begun several years ago at Georgetown University School of Medicine, Washington, DC, and Memorial Sloan-Kettering Institute for Cancer Research, New York City, in response to public pressure for legalization of heroin as a pain medication (<i>JAMA</i>MEDICAL NEWS 1978;240:1567-1575). The American Medical Association continues to oppose such legalization. In neither trial did heroin, also called diamorphine and diacetylmorphine, differ significantly from equianalgesic doses of morphine in its ability to relieve pain, alter mood, or cause side effects, according to pharmacologists Robert F. Kaiko, PhD, of Sloan-Kettering, and William T. Beaver, MD, of Georgetown. The Sloan-Kettering investigators found heroin to be twice as
QUERIES RE SCHIZOPHRENIA
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
OCULAR VERTIGO
Authors: ALLEN GREENWOOD
Journal: JAMA (1913)

îïbwever, after the handling of the operation may be assumed to have lost its spasm and any double vision would then indicate an over effect.Many opthalmologists would refuse to operate for insufficiency of convergence with esophoria in the distance and the patient would get no relief.I wish to state most emphatically that we do not operate unless we are satisfied that exercise will not correct the insufficiency.We do not rashly advise operation.The few patients on whom we operate could obtain relief from their prostrating symptoms in no other way.They should be relieved because if help is refused they go from pillar to post, have their glasses eter- nally changed, and become prey for quacks.
The Exchange
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Penelope
Authors: George N. Braman
Journal: Annals of Internal Medicine (2004)

Ad Libitum6 January 2004PenelopeGeorge N. Braman, MDGeorge N. Braman, MDFrom Bronx, NY 10471Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-140-1-200401060-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail She waits, repeating patterns, ripping them out,Unweaving her work, concealing her ruse,Observing the suitors grumble and pout—Adhering to her implacable muse.She dreams of Odysseus, far away,Plowing the seas as once he plowed the field—Casting about with each tempest or spray—And still she resists, refusing to yield;And still she sits, prepared for his return,Watching the ocean for signs of a sail,Prompting the suitors to languish and burn—The long years unraveled to no avail.At last he comes home and she makes him wait—Their entwined deceptions to contemplate. Author, Article, and Disclosure InformationAffiliations: From Bronx, NY 10471Current Author Address: George N. Braman, MD, 6142 Delafield Avenue, Bronx, NY 10471. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 6 January 2004Volume 140, Issue 1Page: 66KeywordsBurnsDeception ePublished: 6 January 2004 Issue Published: 6 January 2004 Copyright & PermissionsCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Infant Feeding
Authors: M. Dynski-Klein
Journal: BMJ (1964)

IL-4 receptor signaling is supposed to play a major role in anti-inflammatory polarization and proliferation of adipose tissue macrophages. In this study, we examined the metabolic and inflammatory phenotype of C57BL/6J mice (<i>IIl4ra</i>) with LysM-dependent knockout (<i>IIl4ra</i><sup>Δmyel</sup>) of the IL-4 receptor α-chain (IL-4Rα), the mandatory signaling component of IL-4 and IL-13, on chow and high-fat diet. Lean <i>IIl4ra</i><sup>Δmyel</sup> mice showed decreased insulin sensitivity, no divergent adipose tissue macrophage polarization, but an increased percentage of CD8<sup>+</sup> T cells in visceral adipose tissue. After 20 wk of a high-fat diet, <i>IIl4ra</i><sup>Δmyel</sup> mice exhibited higher glucose tolerance, no changes in the lymphocyte compartment and fewer M1 macrophages in visceral adipose tissue. In vivo adipose tissue macrophage proliferation measured by BrdU incorporation was unaffected by <i>Il4ra</i> knockout. Interestingly, we show that IL-4Rα signaling directly augmented <i>Itgax</i> (<i>Cd11c</i>) gene expression in bone marrow–derived macrophages and increased the amount of CD11c<sup>+</sup> macrophages in adipose tissue explants. Myeloid cell–specific knockout of <i>Il4ra</i> deteriorated insulin sensitivity in lean mice but improved parameters of glucose homeostasis and partially protected from adipose tissue inflammation in obese mice. Hence, IL-4Rα signaling probably plays a minor role in maintaining the macrophage M2 population and proliferation rates in vivo. Moreover, our data indicate that IL-4 signaling plays a proinflammatory role in adipose tissue inflammation by directly upregulating CD11c on adipose tissue macrophages.