tbuckley/cabot-search huggingface dataset:
Therapeutics.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 2853: Cell motility and invasiveness are promoted by guanylate binding protein 1, GBP-1 in lung adenocarcinoma
Authors: Takahiro Mimae, Ichiko Yamakita, Yasuhiro Tsutani, Yoshihiro Miyata, Akihiko Ito, Morihito Okada
Journal: Cancer Research (2019)

Abstract Previously, we identified candidate molecules involved in human lung adenocarcinoma progression from non-invasive to invasive tumor by comparing gene expression profiles of each component in the same tumor using laser microdissection and DNA microarray analysis. Among them, guanylate-binding protein 1 (GBP-1) was selected for further analysis because RT-PCR for normal lung and invasive human lung adenocarcinoma tissue samples showed that the relative GBP-1 gene expression levels normalized to GAPDH for invasive lung adenocarcinoma were approximately three-fold higher than those for normal lung samples. In addition, GBP-1 gene and protein expression levels were also higher in mesenchymal-like than in epithelial-like lung cancer cell lines. To determine whether GBP-1 is involved in lung adenocarcinoma cell motility and invasion, we performed migration and wound healing assays using RERF-LC-OK, human lung adenocarcinoma cells transfected with siRNAs. The relative migration of transfected GBP1-siRNA cells was significantly lower than that of control-siRNA cells. The relative wound healing capacities were assessed after scratching. Cells transfected with GBP1-siRNAs were also significantly lower than those of the control-siRNAcells. Moreover, Immunohistochemistry of 80 patients with stage I lung adenocarcinoma demonstrated that non-invasive component cells showed clearly negative GBP-1 expression in all cases. On the other hand, invasive component cells were GBP-1 positive in 10 cases (12.5%) and GBP-1 negative in 70 cases (87.5%). Lymphatic-vascular invasion was positive in 20 patients (25%) and positively correlated with GBP-1 expression (P&amp;lt; 0.05). In conclusion, GBP-1 might enhance lung adenocarcinoma cell motility and invasiveness and controlling of GBP-1 expression has the potential to contribute to the development of novel therapeutic strategies for lung adenocarcinoma. Citation Format: Takahiro Mimae, Ichiko Yamakita, Yasuhiro Tsutani, Yoshihiro Miyata, Akihiko Ito, Morihito Okada. Cell motility and invasiveness are promoted by guanylate binding protein 1, GBP-1 in lung adenocarcinoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2853.
Recent events of special interest to medical education
Authors: C. H. Ruhe
Journal: JAMA (1980)

For the 15th consecutive year Section I of the EDUCATION ISSUE is devoted to "Recent Events of Special Interest to Medical Education." Information has been included about special studies, reports, legislation, and other events and activities that are related to medical education and may be expected to influence its future course and direction. The most significant development during the past year has been the reconsideration and redesign of the structure and function of the various liaison committees responsible for the accreditation of medical education. Since last year's report, a new spirit of reconciliation and accommodation has prevailed among the major organizations responsible for the control and direction of medical education. At the time this report was prepared, negotiations were in progress to redefine the separate roles of the liaison committees and their relationship to each other. Fiscal restraint continues to be the most predominant factor influencing the educational programs of
Symphysiotomy.—
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Ubiquitin Ligase Smurf1 Functions in Selective Autophagy of Mycobacterium tuberculosis and Anti-tuberculous Host Defense
Authors: Luis H. Franco, Vidhya R. Nair, Caitlyn R. Scharn, Ramnik J. Xavier, Jose R. Torrealba, Michael U. Shiloh, Beth Levine
Journal: Cell Host & Microbe (2017)
Cluster headache
Authors: A. D. Nesbitt, P. J. Goadsby
Journal: BMJ (2012)

<b>Background:</b> There are many identifiable factors that contribute to resident satisfaction including work hours, time off, team dynamics, and personal factors. However there are many factors that lead to resident dissatisfaction that are not apparent in the daily work environment, even to the most astute program director. In order to shed light on resident concerns and implement meaningful change within our program we initiated weekly resident and program director meetings. This relatively simple action was designed to improve communication, as well as serve as a forum to address concerns within the program. <b>Design/Methods:</b> A weekly confidential 30 minute meeting with all neurology residents and the program director was implemented. At this meeting residents could voice any concerns with the program, as well as receive updates from the PD on departmental changes. A 10 question survey on resident satisfaction as well as several ACGME survey questions was given to each neurology resident. We collected survey data prior to and 3 months after the implementation of weekly program director meetings. <b>Results:</b> A total of 7/10 residents completed the survey. There was significant improvement in nearly all aspects of resident satisfaction. These included: Overall program satisfaction, the ability to raise concerns without fear of intimidation or retaliation, faculty and staff create an environment of inquiry, program provides a way to transition care when fatigues, responsiveness of program to resident concerns, and the likelihood that the resident would recommend the program to a neurology applicant. All residents answered that they would like to continue weekly meetings. <b>Conclusions:</b> With the simple implementation of regular meetings between residents and program directors there was a significant improvement in resident satisfaction within a small neurology program. These results may lead to improved ACGME survey results, enhanced program communication, and better team morale. <b>Disclosure:</b> Dr. Baldwin has nothing to disclose.
The use of anencephalic infants as organ sources. A critique
Authors: D. A. Shewmon
Journal: JAMA (1989)

The recent abandonment of the only active US protocol for harvesting organs from anencephalic "donors" indicates both the practical and the ethical problems inherent in such an effort. Various data suggest that surprisingly few such organs would actually end up benefiting other children. Attempts to revise either the Uniform Anatomical Gift Act or the Uniform Determination of Death Act to allow organ removal from spontaneously breathing anencephalic infants face major ethical objections. Even if this posed no ethical problem in theory, the ultimate harm to society would not be offset by the good of the few surviving recipients of these organs. Furthermore, providing anencephalic infants with intensive care would tend to preserve the brain stem as effectively as the other organs, predictably rendering the occurrence of brain death unlikely. Thus, despite the great need for newborn organs, anencephalic infants are not as attractive a source as some had hoped. (<i>JAMA</i>. 1989;261:1773-1781)
A Time-Series Analysis of Acidic Particulate Matter and Daily Mortality and Morbidity in the Buffalo, New York, Region
Authors: R. Charon Gwynn, Richard T. Burnett, George D. Thurston
Journal: Environmental Health Perspectives (2000)

A component of particulate matter (PM) air pollution that may provide one biologically plausible pathway for the observed PM air pollution-health effect associations is aerosol acidity (H(+)). An increasing number of observational studies have demonstrated associations between H(+) and increased adverse health effects in the United States and abroad. Although studies have shown significant H(+) associations with increased morbidity in the United States, similar associations have yet to be shown with daily mortality. We considered a 2.5-year record of daily H(+) and sulfate measurements (May 1988-October 1990) collected in the Buffalo, New York, region in a time-series analysis of respiratory, circulatory, and total daily mortality and hospital admissions. Other copollutants considered included particulate matter [less than/equal to] 10 microm in aerodynamic diameter, coefficient of haze, ozone, carbon monoxide, sulfur dioxide, and nitrogen dioxide. Various modeling techniques were applied to control for confounding of effect estimates due to seasonality, weather, and day-of-week effects. We found multiple significant pollutant-health effect associations--most strongly between SO(4)(2-) and respiratory hospital admissions (as indicated by its t-statistic). Additionally, H(+) and SO(4)(2-) demonstrated the most coherent associations with both respiratory hospital admissions [H(+): relative risk (RR) = 1. 31; 95% confidence interval (CI), 1.14-1.51; and SO(4)(2-): RR = 1. 18, CI, 1.09-1.28] and respiratory mortality (H(+): RR = 1.55, CI, 1. 09-2.20; and SO(4)(2-): RR = 1.24, CI, 1.01-1.52). Thus, acidic sulfate aerosols represent a component of PM air pollution that may contribute to the previously noted adverse effects of PM mass on human health, and the associations demonstrated in this study support the need for further investigations into the potential health effects of acidic aerosols.
British Association for the Study of the Liver
Authors: S Vento, L Guella, F Mirandola, L Cosco, T Ferraro, E Concia, H Devereux, T Telfer, D Brown, A Morris, G Dusheiko, V Emery, C Lee
Journal: Gut (1995)

Acute liver failure following withdrawal of chemotherapy has been described in patients with HBV related chronic liver disease; in contrast, no cases have been reported so far in patients with HCV infection.We describe two such cases.Case 1. Forty year old man with a two year history of chronic hepatitis C (genotype lb) and non-Hodgkin's lymphoma treated for 10 weeks with adriamycin, cyclophosphamide, vincristine, bleomycin, etoposide, prednisolone.Two weeks after starting prednisolone reduction from 50 to 10 mg daily, fulminant hepatitis developed (ALT 6030 IU/L, AST 3575, bilirubin 17-2 mg/dl, prothrombin 15% of normal, grade III coma).Serum HCV-RNA was positive (102 genome equivalents/ml); HBsAg, IgM anti-HBc, HDV, HAV, CMV, EBV, HIV antibodies, ANA, AMA, SMA, LKM were negative.The patient died six days later; necropsy showed massive hepatocyte necrosis.Case 2. Thirty one year old man with a six year history of chronic hepatitis C (genotype 2a) and Hodgkin's lymphoma treated with four courses of doxorubicin, bleomycin, vinblastine, dacarbazine.At the end of treat- ment HCV-RNA was very high (108/ml); ALT was 98 IUlL, AST 64.Twenty four days after stopping treatment fulminant hepatitis developed (ALT 3870, AST 3220, bilirubin 11-8 mg/dl, prothrombin 22%, grade II coma).Serum HCV-RNA was reduced to 102/ml.Autoantibodies, HIV abs, HBsAg, IgM anti-HBc, HDV, HAV, CMV, EBV were negative.The patient recovered in 50 days but HCV-RNA remained positive.Massive liver cell necrosis can occur in chronic carriers of HCV on withdrawal of chemotherapy, suggesting an immune medi- ated mechanism of hepatocyte damage.Monitoring of aminotransferases is manda- tory in HCV infected patients receiving cytotoxic treatments.
Retropubic Prostatectomy
Authors: George Austen, William C. Quinby
Journal: New England Journal of Medicine (1948)

UNTIL recently time and experience had accepted as satisfactory three principal operative approaches to the prostate: perineal prostatectomy, suprapubic transvesical prostatectomy and transurethral prostatectomy. No single one of these procedures alone is applicable for the treatment of every type of prostatic obstruction. In spite of the contention of surgeons who are strong proponents of one method to the exclusion of the others, it seems fair to say that each of these procedures has certain indications and contraindications, as well as certain limitations and disadvantages, and that each is attended by various technical difficulties that may render the results of operation . . .
Cardiac Arrest in Infants After Congenital Heart Surgery
Authors: John F. Rhodes, Andrew D. Blaufox, Howard S. Seiden, Jeremy D. Asnes, Ronda P. Gross, Julianna P. Rhodes, Randall B. Griepp, Anthony F. Rossi
Journal: Circulation (1999)

Background —The survival rate to discharge after a cardiac arrest in a patient in the pediatric intensive care unit is reported to be as low as 7%. The survival rates and markers for survival strictly regarding infants with cardiac arrest after congenital heart surgery are unknown. Methods and Results —Infants in our pediatric cardiac intensive care unit database were identified who had a postoperative cardiac arrest between January 1994 and June 1998. Parameters from the perioperative, prearrest, and resuscitation periods were analyzed for these patients. Comparisons were made between survivors and nonsurvivors. Of 575 infants who underwent congenital heart surgery, 34 (6%) sustained a documented cardiac arrest; of these, 14 (41%) survived to discharge. Perioperative parameters, ventricular physiology, and primary rhythm at the time of arrest did not influence outcome. Prearrest blood pressure was lower in nonsurvivors than in survivors ( P &lt;0.001). A high level of inotropic support prearrest was associated with death ( P =0.06). Survivors had a shorter duration of resuscitation ( P &lt;0.001) and higher minimal arterial pH ( P &lt;0.02) and received a smaller total dose of medication during the resuscitation. Although survivors had an overall shorter duration of resuscitation, 5 of 22 patients (23%) survived to discharge despite resuscitation of &gt;30 minutes. Conclusions —The outcome of cardiac arrest in infants after congenital heart surgery was better than that for pediatric intensive care unit populations as a whole. Univentricular physiology did not increase the risk of death after cardiac arrest. Infants with more hemodynamic compromise before the arrest as demonstrated with lower mean arterial blood pressure and higher inotropic support were less likely to survive. The use of predetermined resuscitation end points in this subpopulation may not be justified.
Scientific Program
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Quinidine Hepatotoxicity?
Authors: JOHN W. WINKLER
Journal: Annals of Internal Medicine (1973)

Comments and Corrections1 March 1973Quinidine Hepatotoxicity?JOHN W. WINKLER JR., M.D.JOHN W. WINKLER JR., M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-78-3-460 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In the October 1972 issue (pp. 595-597) Deisseroth, Morganroth, and Winokur report the occurrence of hepatotoxicity apparently caused by quinidine during two separate periods of its use by a patient under treatment for ventrictular premature contractions. The authors state this is the second reported case of this toxic effect, the only other case being from the Danish literature (1).The clinical and laboratory changes coincided with the administration of quinidine gluconate on two separate occasions and cleared after its withdrawal. The authors pointed out that an interaction of quinidine with one or more of the other agents...References1. COLDING H: Et tilfaelde af kinidinallergi med feber og lever-pavirkning. Ugeskr Laeger 131:1657-1658, 1969 MedlineGoogle Scholar2. DUJOVNE C and SHOEMAN D: Toxicity of a hepatotoxic laxative preparation in tissue culture and excretion in bile in man. Clin Pharmacol Ther 13:602-608, 1972 CrossrefMedlineGoogle Scholar3. FINGL E: Cathartics and laxatives, in The Pharmacological Basis of Therapeutics, 4th ed., edited by GOODMAN LS, GILMAN A. New York, The Macmillan Co., 1970, pp. 1026-1027 Google Scholar1. DUJOVNE C and SHOEMAN D: Toxicity of a hepatotoxic laxative preparation in tissue culture and excretion in bile in man. Clin Pharmacol Ther 13:602-608, 1972 CrossrefMedlineGoogle Scholar2. MCHARDY J and BALART L: Jaundice and oxyphenisatin. JAMA 211:83-85, 1970 CrossrefMedlineGoogle Scholar3. DEISSEROTH A, MORGANROTH J, and WINOKUR S: Quinidine-induced liver disease. Ann Intern Med 77:595-597, 1972 LinkGoogle Scholar4. Physicians' Desk Reference to Pharmaceutical Specialties and Biologicals, 25th ed. Oradell, N.J., Medical Economics, Inc., 1970, p. 1201 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JOHN W. WINKLERJR., M.D.Affiliations: 5800 Tenth Place Hyattsville, Maryland PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRepublished: Quinidine hypersensitivity: a side effect of a forgotten antiarrhythmicQuinidine hypersensitivity: a side effect of a forgotten antiarrhythmic 1 March 1973Volume 78, Issue 3Page: 460-460KeywordsClinical laboratoriesPatientsResearch laboratories ePublished: 1 December 2008 Issue Published: 1 March 1973 PDF downloadLoading ...
Wharton's Minor Surgery and Bandaging.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 12576: Impact of Insulin Resistance on Left Ventricular Remodeling in Patients With a First-Time ST Elevation Acute Myocardial Infarction Without Overt Diabetes Mellitus
Authors: Noriaki Iwahashi, Masaomi Gohbara, shunsuke Kataoka, Eiichi Akiyama, Nobuhiko Maejima, KEngo Tsukahara, Kiyoshi Hibi, Masami Kosuge, Toshiaki Ebina, Satoshi Umemura, Kazuo Kimura
Journal: Circulation (2014)

Backgrounds: Insulin resistance (IR) has been reported to be associated with worse prognosis in patients with coronary artery disease. However, the role of IR in patients with acute myocardial infarction(AMI) remains unclear. Therefore, we explored the impact of IR on left ventricular remodeling (LVR) after ST elevation AMI (STEMI) without overt DM. Methods: One hundred seventy patients with a first-time ST elevation AMI (STEMI) who underwent reperfusion within 12 hours were enrolled in this study. Patients had no history of diabetes mellitus prior to their first STEMI. We examined echocardiography results 24 hours after PCI and 12 months later. We measured global longitudinal strain using 3D speckle tracking echocardiography (4D LV Analysis, TOMTEC, Germany). We calculated 3D global longitudinal strain(3D-GLS) as the parameter of accurate systolic function free from tethering effect. Infarct size was defined using Tc99m-sestamibi as the area of &lt;50% uptake at 2 weeks. We checked HOMA-R at 2 weeks. The absolute difference of the LV end-diastolic volume (ΔLVEDV) after 12 months was calculated as a parameter of LVR. We excluded the patients with CKD (eGFR &lt;30ml/min/1.73m2) and the high fasting glucose level (&gt;140mg/dl). Results: Infarct size (r2=0.30, p=0.03) and HOMA-R (r2=0.50, p=0.018) had a good association with ΔLVEDV. There was a significant relationship between HOMA-R andΔLVEDV (r2=0.096, p=0.0007). Multiple regression analysis showed that HOMA-R was the strongest predictor of ΔLVEDV, followed by 3D-GLS (Table). Conclusions: Insulin resistance was the strongest predictor for the degree of LV remodeling in patients with a first STEM without overt DM.