tbuckley/cabot-search huggingface dataset:
Abstract 397: SMARCA4 is a selective vulnerability in SMARCA2-deficient esophageal squamous cell carcinoma cell lines
Authors: Katharina Ehrenhöfer-Wölfer, Teresa Puchner, Silvia Blaha-Ostermann, Alexandra Hörmann, Wolfgang Sommergruber, Norbert Schweifer, Thomas Zichner, Andreas Schlattl, Ralph A. Neumüller, Manfred Koegl, Mark P. Petronczki, Mark Pearson, Simon Wöhrle
Journal: Cancer Research (2019)

Abstract Esophageal squamous cell carcinoma (ESCC) is a highly prevalent tumor type with poor prognosis and limited treatment options. In this study, we aimed to discover potential novel drug targets using a pooled epigenome sgRNA viability screen in a panel of ESCC cell models. We identify the BAF chromatin remodeling helicase subunit SMARCA4/BRG1 as a novel dependency in a subset of ESCC cell lines. In line with the established synthetic lethal interaction of SMARCA4 and SMARCA2/BRM, the two mutual exclusive catalytic subunits of the BAF complex, SMARCA4-dependent cell lines display low or absent expression of SMARCA2. In rescue studies using SMARCA4 variants, we demonstrate that SMARCA4-dependency is linked to its ATPase/helicase activity, but not to bromodomain function. Similarly, ectopic expression of wild-type and bromodomain-mutant SMARCA2, but not a helicase-dead variant, rescues from loss of SMARCA4 in SMARCA2-low ESCC cells. SMARCA2-proficient ESCC cell models are rendered SMARCA4-dependent upon CRISPR/Cas9-mediated knock-out of SMARCA2. We further identify SMARCA4-dependent cell models from additional tumor types (colon, ovarian and pancreas carcinoma) with low or absent SMARCA2 expression. These findings expand the concept of SMARCA2/SMARCA4 paralog dependency and indicate pharmacological inhibition of SMARCA4 as a novel opportunity for targeted therapy of SMARCA2-deficient cancers. Citation Format: Katharina Ehrenhöfer-Wölfer, Teresa Puchner, Silvia Blaha-Ostermann, Alexandra Hörmann, Wolfgang Sommergruber, Norbert Schweifer, Thomas Zichner, Andreas Schlattl, Ralph A. Neumüller, Manfred Koegl, Mark P. Petronczki, Mark Pearson, Simon Wöhrle. SMARCA4 is a selective vulnerability in SMARCA2-deficient esophageal squamous cell carcinoma cell lines [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 397.
Detection of Diabetes Mellitus
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Response
Authors: K. T. BOGEN
Journal: JNCI Journal of the National Cancer Institute (1990)

Journal Article Response Get access KENNETH T. BOGEN KENNETH T. BOGEN University of California Lawrence Livermore National Laboratory Environmental Sciences Division L-453P.O. Box 808 Livermore, CA 94550 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 82, Issue 4, 21 February 1990, Page 320, https://doi.org/10.1093/jnci/82.4.320-a Published: 21 February 1990
Registrars’ Symposium
Journal: British Journal of Dermatology (2012)

British Journal of DermatologyVolume 167, Issue s1 p. 8-12 Free Access Registrars’ Symposium First published: 03 July 2012 https://doi.org/10.1111/j.1365-2133.2012.10936.xAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Volume167, Issues1Special Issue: Abstracts for the British Association of Dermatologists 92nd Annual Meeting. Birmingham, U.K. 3-5 July 2012.July 2012Pages 8-12 RelatedInformation
SURG-23. PATIENT EXPERIENCE AND SATISFACTION WITH DEXMEDETOMIDINE IN AWAKE CRANIOTOMY FOR BRAIN TUMOURS
Authors: Joy Roach, Crispin Weidmann, Richard Chapman, Vasileios Apostolopoulos, Victoria Wykes, Paul Grundy
Journal: Neuro-Oncology (2016)

Gross total excision of high and low grade gliomas has been proven beneficial both by prolonging progress free survival and overall survival. In this context awake craniotomies for tumour resections as close as possible to eloquent brain have become popular. Patient experience has improved dramatically with the advent of the electromagnetic navigation which does not require rigid pin fixation and allows conscious sedation throughout the procedure (AAA). Similarly new sedative medications like Dexmedetomidine have become available aiming to achieve the same level of sedation with less respiratory depression. In this survey we used Dexmedetomidine intravenously to achieve conscious sedation in 40 consecutive patients undergoing awake craniotomy for an eloquently located brain tumour. After the patients recovered from the operation and were discharged, they were asked to complete a questionnaire that explored the way they experienced the awake craniotomy before, during and after the procedure. Dexmedetomidine use for awake craniotomies is standard practice in North America, but in this work we present the first UK experience of a series of patients. 32/40 responses received. Amongst these 19 patients remember being comfortable during the operation, 6 patients felt some discomfort, and 7 patients were not able to remember and comment on their experience during the operation. From the anaesthetic point of view none of these patients required any intraoperative airway intervention. The satisfaction results are comparable to a previous survey carried out in our unit in 2011 looking at the level of satisfaction with Propofol and Remifentanil. The outcome of our survey looking at the use of dexmedetomidine +/- remifentanil matches the previous study in our institution using remifentanil+/-propofol and appears to be as equally as tolerated by patients. The use of dexmedetomidine has the added benefit of little or no respiratory depression. Larger studies are required to explore the true potential of dexmedetomidine further.
Design of practical fat-controlled diets. Foods, fat composition, and serum cholesterol content
Authors: H. B. Brown
Journal: JAMA (1966)

The effects of changing the kind and amounts of animal products, eggs, and oil in a vegetable-oil (standard) diet on serum cholesterol levels was studied in young, normal subjects in 18-day quantitative diet tests. Comparison of serum cholesterol reduction with standard and variant diets in the same subjects showed that effective diets with 38% of calories as fat contained less than 20 gm of animal fat, no more than 8 oz of lean meat/day and 4 eggs/week, and oil with at least 48% polyunsaturates. The fatty acid composition should be below 14% of calories as saturates and more than 15% polyunsaturates. The diet should contain less than 450 mg of cholesterol. An effective moderate fat diet (30% of calories) contained under 10% saturates and over 13% polyunsaturates.
Studies of the Toxic Interactions of Disinfection By-Products
Authors: R. Dana Laurie, J. Peter Bercz, Thomas K. Wessendarp, Lyman W. Condie
Journal: Environmental Health Perspectives (1986)

A large number and variety of compounds are formed in the process of chlorinating drinking water. The classes of compounds formed include trihalomethanes, haloacetic acids, haloacetonitriles, halophenols, and halopropanones. Many of the compounds have been shown to be toxic and are currently being further evaluated by the U.S. Environmental Protection Agency (EPA). One group of the halopropanones found in chlorinated drinking water is the dichloropropanones. The toxicological properties of this group have not been well characterized. In addition, a number of investigators have shown that ketones potentiate the hepatotoxicity of haloalkanes. We conducted a series of studies to explore both the toxicity of the dichloropropanones and their potential interactions with a well-characterized haloalkane, carbon tetrachloride. A variety of toxicological and biochemical endpoints were used to evaluate the toxicity of the dichloropropanones and their interaction with CCl4, including cytochrome P-450 concentration, reduced glutathione levels, pentane generation, serum enzyme activities, and histopathology. Administration of 1,1-dichloropropanone (DCP) resulted in elevated serum enzymes associated with periportal necrosis. Glutathione levels were reduced by the administration of 1,1-DCP; pentane generation was not increased. When 1,1-DCP was given prior to CCl4, the data were consistent with additivity. Administration of 1,3-DCP did not result in elevated serum enzymes, nor was there histopathologic evidence of necrosis. Glutathione levels and pentane generation in the 1,3-DCP-treated groups were the same as those of controls. Inhibition of the toxicologic effects of CCl4 in a dose-related manner was observed when 1,3-DCP was administered prior to CCl4.
THE PROBLEM OF OTOSCLEROSIS
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tryptophan-associated eosinophilic connective-tissue disease. A new clinical entity?
Authors: D. J. Clauw
Journal: JAMA (1990)

Seven patients who developed a syndrome of eosinophilia, connective-tissue disease, and cutaneous abnormalities while ingesting tryptophan were examined. Other clinical manifestations commonly seen were pulmonary symptoms, fever, lymphadenopathy, and the development of myopathy. Laboratory features included mild elevations of aldolase and lactate dehydrogenase levels, with essentially normal creatine kinase levels, erythrocyte sedimentation rates, and C-reactive protein levels. Biopsy findings included features of scleroderma, small-vessel vasculitis, fasciitis, and myopathy. Discontinuation of tryptophan administration and implementation of corticosteroid therapy were of some benefit in relieving the intense myalgias and cutaneous findings that developed. Although temporally related to tryptophan ingestion, it is unclear whether this substance, a metabolite, or a contaminant were causal. We speculate that the pathogenesis of this syndrome may relate to abnormalities in tryptophan metabolism. (<i>JAMA</i>. 1990;263:1502-1506)
Epidemiology in Action Course
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pediatric AIDS: The Challenge of HIV Infection in Infants, Children, and Adolescents
Authors: None Pizzo
Journal: JAMA (1991)

<i>Pediatric AIDS: The Challenge of HIV Infection in Infants, Children, and Adolescents</i>is a welcome, much-needed book on the important subject of the acquired immunodeficiency syndrome (AIDS) in these age groups. Drs Pizzo and Wilfert have compiled an excellent resource in a timely and complete manner. Considering how rapidly this field is moving, the book is remarkably up to date. This book is superb as a reference; it is inclusive and well documented. Six major sections (each with multiple chapters) deal with epidemiology, biology, diagnosis, clinical manifestations, treatment, and prevention and public policy. However, it is not written or edited to be read from cover to cover, as there is significant overlap among many of the chapters. Individual chapters, particularly those under organ-specific complications, provide extremely useful reviews of a variety of topics, such as skin disorders, myopathies, and the like, not provided by any other source. I hope the
CAPD PERITONITIS
Authors: S.P. Borriello, Pauline Honour, S.F. Beardsworth, H.J. Goldsmith, E. Whitfield, F.M. Parsons, I.H. Ahmed-Jushuf, A.M. Brownjohn, S.J. Coltman, J. Gibson, G.A. Young, J.B. Young, L.D. Gruer, R.S.C. Rodger, J.H. Turney, D. Adu, J. Michael, H.H. Gray, S.J. Eykyn
Journal: The Lancet (1983)
Erythropoiesis
Authors: Frederick Stohlman
Journal: New England Journal of Medicine (1962)

Assay and StandardsA variety of assay methods have been introduced over the past several years. The production of polycythemia, although theoretically an ideal end point, is impractical owing to the time and the amount of erythropoietin required. Moreover, at low doses the effect of erythropoietin appears to be "dampened out" after several injections, and polycythemia does not result.63 Accordingly, a number of assays have been devised having in common measurement of the erythropoietic response of animals with suppressed erythropoiesis. Irradiated,64 fasted,65 dehydrated,66 polycythemic,65 hypophysectomized67 and nitrogen-mustard-treated68 animals have been used. It is difficult to achieve clear-cut results with small . . .
Septic Bursitis
Authors: CHRISTINE SIMONELLI
Journal: Annals of Internal Medicine (1978)

Letters and Corrections1 October 1978Septic BursitisCHRISTINE SIMONELLI, M.D., DAVID ZOSCHKE, M.D., ARTHUR BANKHURST, M.D., RONALD MESSNER, M.D.CHRISTINE SIMONELLI, M.D.Search for more papers by this author, DAVID ZOSCHKE, M.D.Search for more papers by this author, ARTHUR BANKHURST, M.D.Search for more papers by this author, RONALD MESSNER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-89-4-575_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The article "Septic Bursitis in the Prepatellar and Olecranon Bursae. An Analysis of 25 Cases" by Ho, Tice, and Kaplan (Ann Intern Med 89:21-27, 1978) was a welcome update of the scant literature on septic bursitis. One important complication of septic olecranon bursitis not mentioned by these authors is osteomyelitis in the adjacent olecranon process. We are presently treating such a case, as described below.A 28-year-old unemployed black man with systemic lupus erythematosus was admitted with arthralgias, myalgias, and extension of his lupus rash. Medications on admission were 60 mg of prednisone and 3.8 g of...Reference1. MURRAYFIALKROBERTS HMR: Candida arthritis. A manifestation of disseminated candidiasis. Am J Med 60:587-595, 1976 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of New Mexico School of Medicine Albuquerque, NM 87131 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySoft tissue diseaseSeptic bursitisSOFT TISSUE INFECTIONSSEPTIC BURSITIS: EXPERIENCE IN A COMMUNITY PRACTICEInfections of Bursae and TendonsKrankheiten der SchleimbeutelBacterial Infection of the Superficial Subcutaneous BursaePredisposing Factors, Bacteriology and Antibiotic Therapy in 35 Cases of Septic BursitisSeptic bursitis in systemic lupus erythematosusAntibiotic therapy of septic bursitisLesions of Bursae, Tendons and Tendon Sheaths 1 October 1978Volume 89, Issue 4Page: 575-576KeywordsArthralgiaLupus erythematosusMyalgiaOsteomyelitisRashes Issue Published: 1 October 1978 PDF downloadLoading ...
Searle, Not SIBA
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
GUANIDINE BASES AND ESSENTIAL HYPERTENSION
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medicolegal Rounds
Authors: Joseph E. Simonaitis
Journal: JAMA (1974)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BOOK REVIEWS
Authors: E. A. SAUSVILLE
Journal: JNCI Journal of the National Cancer Institute (1990)

BOOK REVIEWS Get access Growth Factors and Their Receptors: Genetic Control and Rational Application, UCLA Symposia on Molecular and Cellular Biology, New Series, Volume 102 . Russell Ross Anthony W. Burgess Tony Hunter , eds. New York : Alan R. Liss, Inc. , 1989 , 318 pp. $120. EDWARD A. SAUSVILLE EDWARD A. SAUSVILLE Division of Medical Oncology Department of Medicine Vincent T. Lombardi Cancer Research Center Georgetown University Medical Center800 Reservoir Rd., N.W. Washington, DC 20007-2197 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 82, Issue 10, 16 May 1990, Pages 874–875, https://doi.org/10.1093/jnci/82.10.874 Published: 16 May 1990