tbuckley/cabot-search huggingface dataset:
QuickStats: Age-Adjusted* Alzheimer’s Disease Death Rates† Among Persons Aged ≥65 Years, by State§ — United States, 2015
Journal: MMWR Morbidity and Mortality Weekly Report (2017)

In 2015, the age-adjusted Alzheimer's disease death rate among persons aged ≥65 years in the United States was 231.0 per 100,000 population. The five states with the highest age-adjusted death rates for Alzheimer's disease were South Carolina (362.8), Washington (349.6), Mississippi (346.5), Tennessee (340.8), and Louisiana (333.6). New York had the lowest rate (99.0), followed by Maryland (128.2), Alaska (131.7), Connecticut (149.3), and the District of Columbia (152.2).
Scientific Independence To Be Major Feature Of AMA Institute for Biomedical Research
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Lumleian Lectures on Some Points in the Natural History of Primitive Dry Pleurisies
Authors: A. Clark
Journal: BMJ (1885)

Lersivirine [UK-453,061, 5-((3,5-diethyl-1-(2-hydroxyethyl)(3,5-<sup>14</sup>C<sub>2</sub>)-1<i>H</i>-pyrazol-4-yl)oxy)benzene-1,3-dicarbonitrile] is a next-generation non-nucleoside reverse transcriptase inhibitor, with a unique binding interaction within the reverse transcriptase binding pocket. Lersivirine has shown antiviral activity and is well tolerated in HIV-infected and healthy subjects. This open-label, Phase I study investigated the absorption, metabolism, and excretion of a single oral 500-mg dose of [<sup>14</sup>C]lersivirine (parent drug) and characterized the plasma, fecal, and urinary radioactivity of lersivirine and its metabolites in four healthy male volunteers. Plasma <i>C</i><sub>max</sub> for total radioactivity and unchanged lersivirine typically occurred between 0.5 and 3 h postdose. The majority of radioactivity was excreted in urine (∼80%) with the remainder excreted in the feces (∼20%). The blood/plasma ratio of total drug-derived radioactivity [area under the plasma concentration-time profile from time zero extrapolated to infinite time (AUC<sub>inf</sub>)] was 0.48, indicating that radioactive material was distributed predominantly into plasma. Lersivirine was extensively metabolized, primarily by UDP glucuronosyltransferase- and cytochrome P450-dependent pathways, with 22 metabolites being identified in this study. Analysis of precipitated plasma revealed that the lersivirine-glucuronide conjugate was the major circulating component (45% of total radioactivity), whereas unchanged lersivirine represented 13% of total plasma radioactivity. In vitro studies showed that UGT2B7 and CYP3A4 are responsible for the majority of lersivirine metabolism in humans.
THE CLOSE OF THE WORLD'S FAIR.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Errata
Journal: BMJ (1845)

MISCELLAN EOUS.bourhood of Edinburgh, but in various districts of Scotland, England, and lreland-excursions to which, as we well, know, his pupils look back with.feelings of the ii'gl,sst satisfaction and delight.The first long ex'ursion was made in 1826, when Stntherlandslire was the distr ct' e;xPfb&.'In 1827 he paid another visit to the same county, accompanied by several pupils.These exculrsions were continued annually in the month of August, and in this way were explored the Floras of various parts of Scotland, stuch as Clova, Glen-Igla, Braemar, B)n-Lawers, the Breadalbane districts, Wigtownshire, Rossshire, &c.The Floras of Cunnemnara, in Ireland, and of North Wales, were also in this way carefilly examined.No one enjoved these trips more than the Professor;and no one was better able to endure their attendant fatigues and hardships.His walking powers were un-
ERRATUM
Authors: William Figg, Nilofer Azad, Edwin Posadas, Virginia Kwitkowski, Seth Steinberg, Lokesh Jain, Christina Annunziata, Lori Minasian, Gisele Sarosy, Herbert Kotz, Ahalya Premkumar, Liang Cao, Deborah Mcnally, Catherine Chow, Helen Chen, John Wright, Elise Kohn
Journal: Journal of Clinical Oncology (2008)
Correction
Journal: BMJ (1955)

can be achieved.More emphasis should be laid on the health visitors' visiting duties than on those of acting as clinic receptionists.Co-operation with the General Practitioner Occasionally a doctor will find that a parent quotes the health visitor as offering advice contrary to his own.This apparent contradiction is usually due to a misapprehension on the part of the mother.Nevertheless, even the most minor difference in advice can be exaggerated to such an extent that the parent is hopelessly confused.
Wound Repair
Authors: John H. Wulsin
Journal: JAMA (1977)

In the second edition of this scholarly work, the title has been shortened by omitting the words "biology and surgery" because, as the authors claim in their preface, "the use of such words seems to stake out claims and define territorial rights rather than meld interest and information." The new volume includes 65 more pages, but the print is somewhat larger. Aside from the addition of occasional paragraphs here and there, such as those dealing with the pharmacology of fibrosis, and aside from a few new references at the end of each chapter, the text, the chapters, and the illustrations are basically unchanged from the first edition. Thus, readers who own and enjoy a first edition need not rush to acquire the second, for their old friend is hardly outdated in style, appearance, manner, or content. Despite the progress in biochemical study of wound healing during the past five years,
Association News.
Authors: M. L. Harris
Journal: JAMA (1904)

<h3>Place of Session of the American Medical Association for 1905.</h3> —Attention is called to the action taken at the last session of the American Medical Association to the effect that any city wishing to invite the Association to meet at that place should present the invitation, together with all available facts concerning hotel accommodations, number and seating capacity of halls available for section meetings, intramural means of transportation, railroad facilities, etc., at least three months before the annual session of the preceding year. In accordance with the above, it is hoped that those cities which desire the Association in 1905 will send their invitations, with all information possible, on or before March 1, 1904.
Schweizerische Medizinische Wochenschrift, Basel
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medical education in the United States. IV. Continuing medical education
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Peripheral Vascular Diseases
Authors: Robert R. Linton
Journal: New England Journal of Medicine (1959)

(Continued)Other grafts. Attempts to utilize other materials for prostheses have not been too encouraging. These include fascial-tube grafts,38,39 tubes of stainless-steel wire mesh42 and chamois.41 Experiments with these were not encouraging; furthermore, most of them were used as replacements of short segments of the abdominal aorta in dogs and therefore did not produce comparable conditions for the longer replacements that are necessary in the human being, especially for long segments to bypass the femoral-artery occlusive disease. Wagner et al.,40 however, reported 3 successful implants of tailored vascular grafts made from the cutis of the abdomen. Unfortunately, their longest follow-up . . .
New group tracks hospitals' drug-resistant bugs
Authors: R. Voelker
Journal: JAMA (1996)

FOR SEVERAL years, infectious disease specialists and public health officials have warned of the onslaught of antibiotic-resistant pathogens. But with little in the way of active, national surveillance, tracking microbial susceptibility patterns has been difficult at best. Now early findings from a new nongovernmental surveillance network confirm some fears and soothe others. "The most serious problem we have is vancomycin-resistant enterococcus," says Richard Wenzel, MD, MSc, professor and chair of internal medicine at the Medical College of Virginia, Richmond, and a director of the Surveillance and Control of Pathogens of Epidemiologic Importance (SCOPE) network. Many of the findings "are consistent with data generated over the past decade" by the Centers for Disease Control and Prevention (CDC), Atlanta, Ga, adds Michael Pfaller, MD, also a SCOPE director and codirector of clinical microbiology laboratories at the University of Iowa College of Medicine, Iowa City. <h3>Trends in Resistance Tracking</h3> SCOPE began collecting data
Inflammatory Bowel Disease
Authors: Howard M. Spiro
Journal: JAMA (1988)

Seven hundred eighty-three pages is a lot to write about one disease, or group of diseases, even if you agree with the editors that there have been enormous advances since a previous edition. Rightly boasting 32 new contributors and many revised chapters, they claim the inevitable duplication as a "convenience." Tighter editing, however, might have cut out 100 pages or so. Still, this book, which the editors regard as a guide to future investigation, is the place to find out what is known—or, alas, what is not known—about inflammatory bowel disease (IBD). The reader of this book is likely to be a gastroenterologist or surgeon, someone delving into IBD in more than cursory details. The sections not only summarize what is known, but establish guidelines for what should be sought out in the future. Some of this might be pie in the sky, but second-year gastroenterology fellows looking to do
Bone Marrow Transplantation
Authors: James O. Armitage
Journal: New England Journal of Medicine (1994)

Bone marrow transplantation is the intravenous infusion of hematopoietic progenitor cells to reestablish marrow function in a patient with damaged or defective bone marrow (Figure 1). Although some have traced the origin of this procedure to the end of the past century, when patients were given bone marrow orally as a treatment for hematologic disorders,1 a more realistic starting point is a 1939 report of a patient who received 18 ml of intravenous marrow from his brother as a treatment for aplastic anemia2. The beginning of modern bone marrow transplantation can be traced to work showing that rodents could . . .
Posttransplant primary CNS lymphoma
Authors: Thanh G. Phan, Brian P. O'Neill, Paul J. Kurtin
Journal: Neuro-Oncology (2000)

The records and neuro-imaging studies of 8 cases of posttransplant primary CNS lymphoma (PT-PCNSL) diagnosed at Mayo Clinic Rochester between 1970 and 1998 were reviewed retrospectively.All patients received organ transplantation.Patients who had hematologic transplantation were not included in the analysis.The median and mean age of the 4 men and 4 women was 45 years (range, 34 to 50 years).The median duration of symptoms before diagnosis was 36 days (range, 5 to 98 days).At diagnosis, the neurologic examination was focally abnormal in 6 of 8 patients.Compared with the initial computed tomographic study, MRI showed 25 additional brain lesions.Only 43.7% of lesions enhanced with contrast agent; of those that did, all but one were heterogeneous.Ependymal contact occurred in 5 patients.MRI lesion burden increased proportionally to the interval between scans.Diagnostic tissue was obtained by stereotactic biopsy from 6 patients and by open biopsy from 2. Hemorrhage occurred in the biopsy area in 4 patients who had stereotactic biopsy and 2 died (all had normal coagulation studies).Slides available for review (7 patients) showed that the tumors were of CD20-positive lineage and were positive for Epstein-Barr virus, using in situ hybridization.Six patients died.Median survival for the cohort was 13 weeks.PT-PCNSL has clinical and imaging features distinct from typical PCNSL.In our series, (1) PT-PCNSL presented nonspeci cally and progressed rapidly, (2) stereotactic brain biopsy had signi cant morbidity, and (3) despite multimodal therapy, survival was poor.
Identification and Quantitation of Microparticles in Solid Materials
Authors: D. R. Bowes
Journal: Environmental Health Perspectives (1974)

Variation in the precise conditions of geological formation may produce variations in the ex- act composition of asbestos minerals of a particular class, and thus in their biological interac- tions.Examples are given of differences in 018/016 ratios, TiO2 content, lattice substitutions, substitution of Al (III) for Si (IV) and attachments to spare hydrostatic charges.
Burns
Authors: Robert H. Demling
Journal: New England Journal of Medicine (1985)

BURNS remain a major health problem throughout the world, although the United States has the highest incidence of burns among all industrialized countries. A U.S. citizen has a 1 in 70 chance of being hospitalized for a burn during his or her lifespan. Only in the past two to three years has there been any evidence of a decline in the incidence of burns. In 1982, more than 2 million patients with burns required medical attention in the United States and more than 10,000 burn-related deaths occurred. Only motor vehicle accidents cause more accidental deaths than burns.1 2 3 The epidemiologic aspects . . .
Correction
Journal: Circulation (2015)

In the article by Mozaffarian et al, “Heart Disease and Stroke Statistics—2015 Update: A Report From the American Heart Association,” which published online December 17, 2014, and appeared in the January 27, 2015, issue of the journal (Circulation. 2015;131:e29–e322. DOI:10.1161/ CIR.0000000000000152), several corrections were needed. These corrections have been made to the current online version of the article, which is available at http://circ.ahajournals.org/content/131/4/e29.full.
HEALTH AND PHYSICAL EDUCATION UNDER FEDERAL SUPERVISION
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Environment & Economics Partners in Progress
Authors: Rebecca Clay
Journal: Environmental Health Perspectives (1995)

ENVIRONMENT & El I rogressWhen 25 high-level represen- tatives from industry and govern- ment, as well as environmental, labor, and civil rights organizations, first sat down together in Washington in the fall of 1993, the event might have been compared to the lion sitting down with the lamb.Often adversaries over the years, these diverse and critical sectors of American society had been assigned the joint challenge of helping to craft realistic U.S. policies that simultaneously encourage economic growth, create jobs, and protect the environment.These leaders are members of the President's Council on Sustainable Development (PCSD), established in June
Clinical Psychiatry. A Text-book for Students and Physicians, Abstracted and Adapted from the Seventh German Editionof Kraepelin's "Lehrbuch der Psychiatrie."
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Evaluation of AMG 531 Efficacy in Nonsplenectomized Patients with Chronic Immune Thrombocytopenic Purpura (ITP) in a Randomized Placebo-Controlled Phase 3 Study.
Authors: David J. Kuter, James B. Bussel, Francis M. Senecal, Louis M. Aledort, Craig M. Kessler, Miguel A. Sanz, Howard A. Liebman, Frank T. Slovick, Reggie Kelly, Matthew Guo, Janet L. Nichol
Journal: Blood (2007)
Remembrances of the war and the bomb
Authors: T. Takemi
Journal: JAMA (1983)

<h3>The Ending of the War</h3> ON THE morning of Aug 6, 1945, an awesome explosion destroyed the city of Hiroshima in the south of the island of Honshu, Japan. Blast and heat devastation from the<i>pikadon</i>were followed by an all-consuming firestorm (<i>pika</i>[bright flash of light];<i>don</i>[loud sound];<i>pikadon</i>came to mean to the people of Hiroshima an explosion consisting of a flash and a boom). There had been severe bombing of many cities in Japan earlier, especially by incendiary bombs, and many sweeping fires had destroyed large areas of cities. The people of Japan were told only that the destruction of Hiroshima was caused by a new kind of bomb. In 1945, I was the only physician studying nuclear physics at the Institute of Physical and Chemical Researches in Tokyo. Dr Yoshio Nishina was our professor. We at the institute immediately surmised that the Hiroshima explosion may
Gastrointestinal Amyloidosis
Authors: Shinji Izuka, Hiroyuki Yamashita
Journal: New England Journal of Medicine (2021)

A 60-year-old woman with rheumatoid arthritis presented with diarrhea and anorexia. Biopsy of colonic erosions showed amyloid deposits with apple-green birefringence on Congo red staining, and a diagnosis of gastrointestinal amyloidosis was made.