tbuckley/cabot-search huggingface dataset:
NEUROFIBRILS.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Retrait progressif du stylet versus aspiration standard pour les biopsies guidées par échoendoscopies de masse solides pancréatiques: un essai randomisé multicentrique
Journal: Endoscopy (2018)

La ponction à l’aiguille fine guidée par écho-endoscopique est la technique de référence pour le diagnostic des lésions solides du pancréas. La technique du retrait lent du stylet de l’aiguille, appelée technique de “slow-pull”, est une alternative à l’aspiration à la seringue, qui permettrait, entre autres, de limiter la contamination des prélèvements par le sang.
Cardiovascular and metabolic toxicity of abiraterone in castration-resistant prostate cancer: Post-marketing experience.
Authors: Phoebe A. Cheng, Jason P. Estes, Jennifer J. Griggs, David C. Smith, Megan Veresh Caram
Journal: Journal of Clinical Oncology (2018)

e17043 Background: Abiraterone improves survival in metastatic castration-resistant prostate cancer (mCRPC) but may result in the development or worsening of comorbid conditions. We assessed the course of these conditions in patients receiving abiraterone in clinical practice and compared outcomes to those in clinical trials. Methods: Medical records of patients with mCRPC who started abiraterone at the University of Michigan between 2012-2015 were reviewed for emergency department (ED) visits, hospitalizations, and the development and/or worsening of key comorbid conditions while on abiraterone. Patient characteristics and adverse events were compared with those from clinical trials. Results: In a cohort of 174 patients, 16% experienced development and 24% worsening of a comorbid disease; 8% required an ED visit or hospitalization due to known adverse effects of abiraterone. Increasing age (odds ratio, OR 1.08, 95% confidence interval, CI 1.01-1.17), higher prostate specific antigen at initiation of treatment (OR 1.68, 95% CI 1.18-2.47), and preexisting uncontrolled hypertension (OR 7.61, 95% CI 1.22-38.70), congestive heart failure (OR 7.61, 95% CI 1.22-38.70), and cardiac arrhythmias (OR 4.73, 95% CI 1.39-15.12) were associated with increased odds of an ED visit or hospitalization due to known adverse effects of abiraterone. Significantly fewer patients (6%) discontinued abiraterone due to toxicity than in one phase III trial that demonstrated abiraterone's efficacy. Conclusions: Few patients discontinued abiraterone due to toxicity; however, the fact that over one quarter of patients experienced the development or worsening of cardiovascular and metabolic diseases warrants development of team-based approaches to the management of these comorbid conditions.
SANITATION IN THE CANAL ZONE.
Authors: W. C. GORGAS
Journal: JAMA (1907)

Being a working doctor and one not accustomed to addressing audiences, I must ask your indulgence in making the attempt. Indeed, I would never have thought of making this address, except that your dean, Dr. Polk, assured me that some account of our sanitary work at Panama would be acceptable. And I can see that an outline of the sanitary work at Panama might be of use to men just being graduated into our profession, as an illustration of a new avenue of useful work in the way of tropical sanitation that has developed in the last eight or ten years. Great advances have been made in this line of work in that period, due to important discoveries made just prior to that time, and the English and Americans have done a great deal of useful work in sanitation in their tropical colonial possessions. The discovery that the bite of
Sentinel node biopsy following neoadjuvant chemotherapy in biopsy proven node positive breast cancer: The SN FNAC study.
Authors: Jean-Francois Boileau, Brigitte Poirier, Mark Basik, Claire Holloway, Louis Gaboury, Lucas Sideris, Sarkis H. Meterissian, Angel Arnaout, Muriel Brackstone, David R. McCready, Stephen Eric Karp, Frances Catriona Wright, Rami Younan, Louise Provencher, Erika Patocskai, Atilla Omeroglu, Andre Robidoux
Journal: Journal of Clinical Oncology (2013)

1018 Background: A significant and increasing proportion of patients (&gt;30%) with biopsy proven node positive breast cancer will obtain a pathological complete response (pCR) in the axilla after neoadjuvant chemotherapy (NAC). If sentinel node biopsy (SNB) can accurately identify these patients, they could potentially avoid the morbidity of an axillary node dissection. The primary aim of this study is to evaluate the identification rate (IR), false negative rate (FNR) and accuracy of SNB in this setting. The accuracy of post NAC axillary ultrasound and clinical examination are evaluated as secondary endpoints. Methods: Patients with biopsy proven node positive breast cancer (T0-3, N1-2, M0) treated with NAC were eligible to participate in this multi-centre prospective trial. Following NAC, axillary ultrasound and clinical examination results were obtained. At time of surgery, all participants underwent both a SNB and a completion node dissection. A SNB IR greater than 90% and a FNR of less than 10% were pre-determined as being optimal. Results: From September 2009 to December 2012, 153 patients were accrued to the study. 7 patients were not eligible and 5 patients had not yet undergone surgery at the time of analysis. Axillary pCR rate = 34.0% (48/141). SNB IR = 87.2% (123/141), 95% CI [81.7%-92.7%] and FNR = 9.9% (8/81), 95% CI [3.4%-16.4%]. If only one sentinel node was removed, FNR = 19.0%(4/21); if there were 2 or more sentinel nodes, FNR = 6.6% (4/61) (p &lt; 0.0001). Accuracy of SNB, axillary ultrasound and clinical examination were 93.5%, 63.2%, and 45.5% respectively. Conclusions: SNB following NAC in biopsy proven node positive breast cancer is associated with a suboptimal IR. FNR (less than 10%) and accuracy of SNB in this study are comparable to that of patients that present with clinically negative nodes. The FNR decreases when more than one sentinel node is identified. However, in an era where regional nodal radiation is increasingly used, the relevance of leaving residual disease in the undissected axilla after NAC is unknown and remains to be investigated. Clinical trial information: NCT00909441.
Publishing Ethics
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
New observations in erythroblastosis fetalis
Authors: R. L. Naeye
Journal: JAMA (1967)

A quantitative morphologic study has been made of body size, organ size, and cellular structure in 23 newborn infants with erythroblastosis fetalis. Spleen, liver, heart, and adrenals were enlarged for gestational age while thymus, brain, and lymph nodes were subnormal in size. The quantitative analysis revealed a hyperplasia of myocardial fibers, of pancreatic islet cells, and of fetal zone adrenal cortical cells. Islet cells and adrenal cortical cells were hypertrophic while cells in other organs had normal dimensions. Individual aspects of these morphologic abnormalities resemble features of other disorders and in some instances a similar pathogenesis may exist.
Infantile overnutrition.
Authors: P D Hooper
Journal: BMJ (1973)

despite vaccination and a good "take," can develop modified smallpox.With regard to the question of severe chickenpox versus smallpox, I think it is sensible and wise to err on the wrong side and regard all severe cases of chickenpox as potential cases of smallpox until proved otherwise.In such situations, in my ex- perience, mapping of the lesions on a ohart and comparing it with Langer's lines2 as shown in the accompanying figure has been found very useful, as the distribution of lesions in chickenpox follows the Langer's lines very closely, whereas those of smallpox do not.Lastly, with regard to laboratory diagnosis I think agar-gel diffusion based on antigen and antibody reaction, a test devised by Dumbell and Nizamuddin,3 has proved outstandingly successful, giving reliable, rapid results in about six hours.-Iam, etc.,
WASHINGTON NEWS
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
KLIEG EYES
Authors: Albert L. Brown
Journal: JAMA (1926)

<h3>To the Editor:</h3> —Recently I investigated the etiology and pathology of Kleig eyes in motion picture studios. The symptoms were so distressing for the time, and of such inconvenient duration, that the persons engaged were at a loss to cope with the situation. The patients have great photophobia and lacrimation, and even when the trouble is not especially severe, are incapacitated because of their appearance and their inability to look at light. The early stages appeared to be a hyperemia, which, if allowed to continue, orexposed to the studio lights for any time, quickly merged into a mild chronicity, which resolved itself into a type of follicular conjunctivitis. In mild cases I sectioned a few specimens of the engorged and follicular conjunctiva, and found beginning hyperplasia of the interstitial tissue, and the follicles were evidently a lymphoid hyperplasia The most effective remedy in early stages seems to be a rather
Facing the complex issues of pediatric AIDS: a public health perspective
Authors: M. T. Osterholm
Journal: JAMA (1987)

Almost seven years have passed since the first recognition of the acquired immunodeficiency syndrome (AIDS) in this country, and during the past four years we have been able to identify many of the clinical and epidemiologic consequences of human immunodeficiency virus (HIV) infection. Although children with AIDS were recognized early in the epidemic, the impact of pediatric AIDS on clinical medicine and society in general is only now being fully appreciated. In this issue ofTHE JOURNAL, Landesman et al<sup>1</sup>provide us with important insights into the pediatric HIV infection problem of today and the AIDS problem of tomorrow through their survey of women delivered of infants at King's County Hospital Center in Brooklyn, NY. In their study of HIV seroprevalence in cord blood samples from 602 infants delivered in an inner-city municipal hospital, Landesman and colleagues found a demographic and HIV risk factor history similar to what is currently
Allergy to Local Anesthetics
Authors: J. Antonio Aldrete
Journal: JAMA (1969)

<h3>To the Editor:—</h3> Two letters appeared in the March 24 issue (<b>207</b>: 2283, 1969) commenting on our article entitled "Allergy to Local Anesthetics (<b>207</b>:356, 1969). Both letters warned against the skin testing of definitely allergic drugs; in this particular case, local anesthetics. Contrary to what was stated in one of the letters (L. H. Criep), this group of drugs cannot be compared to penicillin since their chemical composition is different and the incidence of allergic reactions is considerably larger with the latter drug. Therefore, while the skin testing to penicillin has been debatable, it was recently proven as relatively safe, as indicated in the 13 cases reported by Rosenblum (<i>J Allerg</i><b>42</b>:309, 1968). In the other ten patients that we alluded to in our paper, skin tests were done with local anesthetics and their responses assessed by the passive transfer method (<i>Anesth Analg</i>, to be published). As stated priorly,
Pneumonitis caused by metronidazole
Authors: M. Kristenson
Journal: JAMA (1988)

<h3>To the Editor.—</h3> As many as 50% of patients are admitted to the hospital because of adverse drug reactions; up to 18% of hospitalized patients suffer from side effects of drugs, which sometimes may be fatal.<sup>1</sup>Over 20 years, metronidazole has earned a reputation of being remarkably safe, although in recent years doses and duration of treatment have gradually increased, for example, when treating Crohn's disease.<sup>2</sup> Adverse reactions have mostly been mild and reversible, such as nausea, vomiting, fever, urticaria, and metallic taste, but sometimes can be more severe, such as polyneuropathy, mental confusion, convulsions, and leukopenia. Recently, cases of serum sickness and meningitis have been described. We report a case of pneumonitis caused by metronidazole.<sup>2</sup> <h3>Report of a Case.—</h3> A 42-year-old woman was admitted to the hospital for the first time on Aug 3,1985. She had a known pollen allergy, but no known hypersensitivity to drugs.
The Accumulation of Nickel in Human Lungs
Authors: David A. Edelman, Victor L. Roggli
Journal: Environmental Health Perspectives (1989)

Using data from published studies, lung concentrations of nickel were compare for persons with and without occupational exposure to nickel. As expected, the concentrations were much higher for persons with occupational exposure. To estimate the effects of nickel-containing tobacco smoke and nickel in the ambient air on the amount of nickel accumulated in lungs over time, a model was derived that took into account various variables related to the deposition of nickel in lungs. The model predicted nickel concentrations that were in the range of those of persons without known nickel exposure. Nickel is a suspected carcinogen and has been associated with an increased risk of respiratory tract cancer among nickel workers. However, before the nickel content of cigarettes can be implicated in the etiology of lung cancer, further studies are needed to evaluate the independent effects of smoking and exposure to nickel.
Clevenger on Spinal Concussion.
Journal: JAMA (1890)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction
Journal: BMJ (1961)

Inheritance of Fraglitas 0i ,Q.-What is the hereditary nature of fragilitas ossium?Is there any tendency for it to be transmitted through males or females ?A.-Fragilitas ossium (or osteogenesis imperfecta) in nearly all, perhaps all, cases is due to a dominant mutant gene.' 2 a This is probably true also of the congenital forms (Vrolik's disease), though the lethal nature of this most severe variant of the disorder makes genetic study difficult.The condition is transmitted equally through males and females.
Gold Cures.
Authors: T. D. Crothers
Journal: JAMA (1898)

Hartford, Conn., Nov. 28, 1898. <h3>To the Editor:</h3> —In my paper on "Gold Cures in Inebriety," in theJournalof October 1, no reference was made to any combination of gold with other drugs for any diseases beyond inebriety. The managers of mercauro and arsenauro, well-known combinations of mercury and arsenic with gold, have misconstrued my statements to be reflections on their preparations. In this they are very much mistaken; no possible criticism was, or could be intended, and more especially as I have used this prescription in many cases with good results, and have repeatedly spoken of it in the<i>Journal of Inebriety</i>. My criticism was directed only to specifics of any form which sought to bring about results known to be impossible. Very truly,
Psychiatric Jargon
Authors: W. KEITH C. MORGAN
Journal: Annals of Internal Medicine (1977)

Letters and Corrections1 December 1977Psychiatric JargonW. KEITH C. MORGAN, M.D.W. KEITH C. MORGAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-87-6-798_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In the review article by Leigh and Reiser (Ann Intern Med87:233-239, 1977) is the following passage: "As Lipowski pointed out in 1974, the essence of consultation-liaison psychiatry today is a holistic approach to the total patient, in his biologic, psychologic, and social dimensions. This approach is obviously inimical to the simple reductionistic ones, whether to unconscious conflicts or twisted molecules." I assume the first sentence could equally well read, "Psychiatrists (behavioral medicine specialists?) when doing consultations should consider the whole patient." I cannot but wonder how one can have a holistic approach to a less than... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited BySynthesis and antitumor activity of bicyclo[3.3.1]nonenol derivatives 1 December 1977Volume 87, Issue 6Page: 798-798KeywordsBiologics Issue Published: 1 December 1977 PDF DownloadLoading ...
Late Breaking Poster Session LB TPS 10-18
Journal: Allergy (2016)

Background: Reactions to an extensively hydrolysed formula (eHF) has been reported in patients with cow's milk protein allergy(CMPA), but they ultimately responded therapeutically to an amino acid-based formula (AAF).The purpose of the open-label prospective postregistration trial was to evaluate the efficacy and safety of feeding AAF longterm in infants who were intolerant to eHF.Method: Thirty one infants (mean age 4.9 AE 1.2 months) with CMPA with moderate and severe atopic dermatitis (AD) who were intolerant to eHF defined as persistence of: AD and/or gastrointestinal (GI) manifestations of CMPA-17 children (bloody stools, vomiting, diarrhea, colic, irritability/tears and failure to thrive) were recruited.We determined if fecal calprotectin (FC) can be used as a marker for follow-up inflammation in GI tract in CMPA.AD was assessed using SCORAD, weight and height were documented.Patients received an AAF for at least 6 months were then orally challenged with the eHF.At the end of the study parents filled out the questionnaire about their experience of using AAF.Results: AAF was used for a duration of 6 to 12 months or more and proved safe in all cases.All infants gained weight and increased height statistically significant (P < 0.005).During 4-week dietotherapy cycle there was an abolishment of skin symptoms of CMPA (SCORAD 46.84 (SD 4.16) and 2.52 (SD 2.2)) and reduction in needs for topical glucocorticosteroids, calcineurin inhibitors and antihistamines (P < 0.001).After 14 days of treatment with AAF all children demonstrated clinical resolution of their GI symptoms.We found significant reduction of FC level in 18 children with increased level (15 children with GI and 3 without GI manifestations of CMPA) since one month of treatment (P < 0.001).38.7% of children were transferred to eHF in 6 months, 12.9% and 25.8% in 9 and 12 months respectively.So 77.4% of children with CMPA were successfully transferred to eHF during 12 months.Conclusion: Using AAF in children under one year with CMPA is highly effective and safe method of treatment, based on doctor's and parent's opinions.The test formula is well tolerated and ensures child's growth and development.During dietotherapy cycle there was an abolishment of GI and skin symptoms of CMPA and reduction in needs for topical drugs and antihistamines.AAF doesn't prolong the period of tolerance's formation.The determination of FC levels may be a useful marker for follow-up treatment of CMPA.