tbuckley/cabot-search huggingface dataset:
Immunohistochemistry Versus Microsatellite Instability Testing in Phenotyping Colorectal Tumors
Authors: Noralane M. Lindor, Lawrence J. Burgart, Olga Leontovich, Richard M. Goldberg, Julie M. Cunningham, Daniel J. Sargent, Catherine Walsh-Vockley, Gloria M. Petersen, Michael D. Walsh, Barbara A. Leggett, Joanne P. Young, Melissa A. Barker, Jeremy R. Jass, John Hopper, Steve Gallinger, Bharati Bapat, Mark Redston, Stephen N. Thibodeau
Journal: Journal of Clinical Oncology (2002)

To compare microsatellite instability (MSI) testing with immunohistochemical (IHC) detection of hMLH1 and hMSH2 in colorectal cancer.Colorectal cancers from 1,144 patients were assessed for DNA mismatch repair deficiency by two methods: MSI testing and IHC detection of hMLH1 and hMSH2 gene products. High-frequency MSI (MSI-H) was defined as more than 30% instability of at least five markers; low-level MSI (MSI-L) was defined as 1% to 29% of loci unstable.Of 1,144 tumors tested, 818 showed intact expression of hMLH1 and hMSH2. Of these, 680 were microsatellite stable (MSS), 27 were MSI-H, and 111 were MSI-L. In all, 228 tumors showed absence of hMLH1 expression and 98 showed absence of hMSH2 expression: all were MSI-H.IHC in colorectal tumors for protein products hMLH1 and hMSH2 provides a rapid, cost-effective, sensitive (92.3%), and extremely specific (100%) method for screening for DNA mismatch repair defects. The predictive value of normal IHC for an MSS/MSI-L phenotype was 96.7%, and the predictive value of abnormal IHC was 100% for an MSI-H phenotype. Testing strategies must take into account acceptability of missing some cases of MSI-H tumors if only IHC is performed.
Diseases of the Colon and Rectum, Philadelphia
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
REFORM IN CHARITABLE INSTITUTIONS.
Journal: JAMA (1905)

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The American Medico-Psychological Association
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cerebral Hemorrhage in Carotid Artery Surgery
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction
Journal: BMJ (1966)

We publish below a selection of questions and answers of general interest.Sterilizing Plastic Pessaries Q.-How should plastic vaginal pessaries be sterilized?Are Hodge-Smith pessaries, with a flexible mid-part, still considered useful, and are they obtainable ?A.-Articles made of vulcanite, nylon, polypropylene, polyvinyl chloride, and poly- ethylene can be sterilized by boiling, though pessaries made of the last two materials are softened with heat and may be deformed if they are handled while hot.Polyvinyl chloride becomes cloudy on boiling owing to the absorption of water, though its properties are unaffected.Polyethylene cannot be autoclaved, and this method of sterilization is unsuitable for polyvinyl pessaries, since they are liable to distortion.Plastic pessaries can also be sterilized by immersing them in an antiseptic solution such as chlorhexidine.Phenolic compounds should not be used, since they are absorbed by plastic materials.However, modern plastic pessaries need not be changed more than once every six months, and they are cheap enough to be discarded and replaced by new ones after use.Hodge pessaries (and various modifica- tions of this basic shape) are mainly used for the temporary correction of retroversion.
Leads from the MMWR. Measles prevention: supplementary statement
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Long term outcomes of Dynamic Sentinel Lymph Node Biopsy (DSNB) for clinically impalpable (cN0) penile cancer patients- an eUROGEN study
Authors: E. Pozzi, O.O. Cakir, F. Castiglione, N. Schifano, P. Hadway, R. Nigam, R. Rees, M. Albersen, A. Parnham, M. Lau, H.M. Alnajjar, S. Vijai, A. Muneer
Journal: European Urology (2021)
Primum non nocere
Authors: R. W. Gifford
Journal: JAMA (1977)

THE DICTUM<i>primum non nocere</i>—first, do no harm—is a carry-over from the distant past and probably originated with Hippocrates, when therapeutics was not based on sound scientific knowledge and rationale and the medicaments available were more likely to be harmful than helpful. If indeed this phrase originated with Hippocrates, it was undoubtedly taken out of context. In "Epidemics," Hippocrates wrote, "As to diseases, make a habit of two things—to help, or at least to do no harm." <h3>The Benefit-Risk Ratio</h3> This was obviously Hippocrates' attempt to define what we now call the "benefit-risk ratio" in modern therapeutics. The problem is that, strictly interpreted and applied in the modern era of scientific therapeutics,<i>primum non nocere</i>prohibits any risk and therefore effectively prevents any meaningful therapeutic endeavor. It becomes the shield of the therapeutic nihilist, the battle cry of consumer advocates to thwart new drug development, and the justification of
Lectures
Authors: D. S. Chen, D. M. Feltquate, F. Smothers, A. Hoos, S. Langermann, S. Marshall, R. May, M. Fleming, F. S. Hodi, A. Senderowicz, K. G. Wiman, S. de Dosso, W. Fiedler, L. Gianni, S. Cresta, H. B. Schulze-Bergkamen, L. Gurrieri, M. Salzberg, B. Dietrich, A. Danielczyk, H. Baumeister, S. Goletz, C. Sessa, D. Strumberg, B. Schultheis, A. Santel, F. Gebhardt, W. Meyer-Sabellek, O. Keil, K. Giese, J. Kaufmann, M. Maio, G. Choy, A. Covre, G. Parisi, H. Nicolay, E. Fratta, E. Fonsatti, L. Sigalotti, S. Coral, P. Taverna, M. Azab, E. Deutsch, C. Lepechoux, J. P. Pignon, Y. T. Tao, S. Rivera, B. C. Bourgier, M. Angokai, R. Bahleda, K. Slimane, E. Angevin, B. B. Besse, J. C. Soria, K. Dragnev, J. H. Beumer, B. Anyang, T. Ma, F. Galimberti, C. P. Erkmen, W. Nugent, J. Rigas, K. Abraham, D. Johnstone, V. Memoli, E. Dmitrovsky, E. E. Voest, L. Siu, F. Janku, J. C. Soria, A. Tsimberidou, R. Kurzrock, J. Tabernero, J. Rodon, R. Berger, A. Onn, G. Batist, C. Bresson, V. Lazar, J. J. Molenaar, J. Koster, M. Ebus, D. A. Zwijnenburg, P. van Sluis, F. Lamers, L. Schild, I. van der Ploeg, H. N. Caron, R. Versteeg, J. Pouyssegur, I. Marchiq, J. Chiche, D. Roux, R. Le Floch, S. E. Critchlow, R. F. Wooster, S. Agresta, K. E. Yen, P. A. Janne, E. R. Plummer, G. Trinchieri, L. Ellis, S. L. Chan, W. Yeo, A. T. Chan, F. Mouliere, S. El Messaoudi, C. Gongora, P. J. Lamy, M. del Rio, E. Lopez-Crapez, B. Gillet, M. Mathonnet, D. Pezet, M. Ychou, A. R. Thierry, V. Ribrag, W. Vainchenker, S. Constantinescu, H. Keilhack, I. A. Umelo, A. Noeparast, G. Chen, M. Renard, C. Geers, J. Vansteenkiste, E. Teugels, J. de Greve, O. Rixe, X. Qi, Z. Chu, J. Celerier, L. Leconte, N. Minet, J. Pakradouni, B. Kaur, F. Cuttitta, A. J. Wagner, Y. X. Zhang, E. Sicinska, J. T. Czaplinski, S. P. Remillard, G. D. Demetri, S. Weng, L. Debussche, L. Agoni, E. P. Reddy, C. Guha, K. Silence, A. Thibault, H. de Haard, T. Dreier, P. Ulrichts, M. Moshir, S. Gabriels, J. Luo, C. Carter, A. Rajan, S. Khozin, A. Thomas, A. Lopez-Chavez, C. Brzezniak, L. Doyle, C. Keen, M. Manu, M. Raffeld, G. Giaccone, S. Lutzker, J. M. Melief, S. G. Eckhardt, L. Trusolino, G. Migliardi, E. R. Zanella, F. Cottino, F. Galimi, F. Sassi, S. Marsoni, P. M. Comoglio, A. Bertotti, M. Hidalgo, S. J. Weroha, P. Haluska, M. A. Becker, S. C. Harrington, K. M. Goodman, S. E. Gonzalez, M. al Hilli, K. A. Butler, K. R. Kalli, A. L. Oberg, I. J. Huijbers, R. Bin Ali, C. Pritchard, M. Cozijnsen, N. Proost, J. Y. Song, P. Krimpenfort, E. Michalak, J. Jonkers, A. Berns, U. Banerji, A. Stewart, P. Thavasu, S. Banerjee, S. B. Kaye
Journal: Annals of Oncology (2013)
Underreporting of AIDS cases in South Carolina, 1986 and 1987
Authors: G. A. Conway
Journal: JAMA (1989)

An evaluation of the completeness and accuracy of case reporting of the acquired immunodeficiency syndrome (AIDS) for the 18-month period from January 1, 1986, through June 30, 1987, was conducted for South Carolina. A total of 596 585 hospital discharge billing records were searched by computer for conditions defining AIDS. The resulting 1513 records were manually reviewed. Of these, 349 discharges for 163 individuals were classified as being definitely AIDS related, the clinical features of these cases meeting Centers for Disease Control criteria for AIDS diagnosis. Of these cases, 153 were reportable to the South Carolina AIDS registry at the time of their diagnosis. Comparison of this case list with registry records revealed that only 91 (59.5%) had been reported. Reporting was significantly poorer for cases among blacks (53.1%) than for cases among whites (71.6%). These findings may have important implications for the interpretation of AIDS surveillance data and for planning activities in which awareness of complete case counts may be critical. (<i>JAMA</i>. 1989;262:2859-2863)
Update: Interim Guidelines for Health Care Providers Caring for Pregnant Women and Women of Reproductive Age with Possible Zika Virus Exposure — United States, 2016
Authors: Titilope Oduyebo, Emily E. Petersen, Sonja A. Rasmussen, Paul S. Mead, Dana Meaney-Delman, Christina M. Renquist, Sascha R. Ellington, Marc Fischer, J. Erin Staples, Ann M. Powers, Julie Villanueva, Romeo R. Galang, Ada Dieke, Jorge L. Muñoz, Margaret A. Honein, Denise J. Jamieson
Journal: MMWR Morbidity and Mortality Weekly Report (2016)
NECROLOGY. [Death From Autopsical Injury or Infection]
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Guidelines for ethics committees in health care institutions. Judicial Council
Authors: Judicial Council
Journal: JAMA (1985)

These guidelines for the establishment and operation of ethics committees in hospitals or other health facilities were drawn up by the Judicial Council of the American Medical Association and approved in December 1984 by the AMA's House of Delegates. The voluntary, educational, and advisory nature of the ethics committee is emphasized, as is the importance of confining its functions to ethical matters. Advice is given on choosing members for the committee, which the Council recommends should be composed primarily of health care professionals. Among the other issues covered by the guidelines are the sources of matters to be considered by the committee, how committee recommendations should be recorded, and the relationship between the committee and the health care institution of which it is a part.
Vaginal spermicides and congenital disorders
Authors: H. Jick
Journal: JAMA (1981)

Among 763 liveborn infants of white women who had obtained a vaginal spermicide in the ten months before conception, the prevalence of certain major congenital anomalies was 2.2%. The prevalence of such anomalies in a comparison group of 3,902 infants was 1.0%. The difference between these groups was due to an excess of limb-reduction deformities, neoplasms, syndromes associated with chromosomal abnormalities, and hypospadias in the infants whose mothers are presumed to have used vaginal spermicides. Pregnancies in women who had used vaginal spermicides ended in spontaneous abortion requiring hospitalization 1.8 times more commonly than did pregnancies in those who had not. Since a well-defined syndrome among babies with congenital disorders whose mothers used spermicides was not present, these results should be considered tentative until confirmed by other data. (<i>JAMA</i>1981;245:1329-1332)
Mechanisms and Molecules that Control Growth Cone Guidance
Authors: C. S. Goodman
Journal: Annual Review of Neuroscience (1996)

The brain's default mode network consists of discrete, bilateral and symmetrical cortical areas, in the medial and lateral parietal, medial prefrontal, and medial and lateral temporal cortices of the human, nonhuman primate, cat, and rodent brains. Its ...Read More
In Utero Fetal Surgery
Journal: JAMA (1983)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Milk Precipitins
Authors: Mary G. McCrea
Journal: JAMA (1968)

Sera from 932 individuals were tested for the presence of precipitins to bovine milk with the micro double-diffusion test in agar. Sixteen percent of the total tested population were positive reactors. Mongols, nonmongoloid patients with profound mental retardation, patients with anemia, and individuals belonging to non-O blood groups manifested a strikingly higher percentage of serum milk precipitins than did the other subjects.
Long-Term Dosing of AMG 531 in Thrombocytopenic Patients with Immune Thrombocytopenic Purpura: 2-Year Update.
Authors: James B. Bussel, D.J. Kuter, J.Th.M de Wolf, T.H. Guthrie, A. Newland, J.S. Wasser, S.I. Hamburg, L. Bjorkquist, M. Guo, J. Nichol
Journal: Blood (2007)
Cardiac arrest due to anesthesia. A study of incidence and causes
Authors: R. L. Keenan
Journal: JAMA (1985)

Cardiac arrests due solely to anesthesia were studied in a large university hospital over a 15-year period. There were 27 cardiac arrests among 163,240 anesthetics given, for a 15-year incidence of 1.7 per 10,000 anesthetics. Fourteen of these patients (0.9 per 10,000) subsequently died. Detailed examination of the data from these 27 patients revealed that the pediatric age group had a threefold higher risk than adults, and that the risk for emergency patients was six times that for elective patients. Failure to provide adequate ventilation caused almost half of the anesthetic cardiac arrests, and one third resulted from absolute overdose of an inhalation agent. Hemodynamic instability in very ill patients was an association in 22%. Specific errors in anesthetic management could be identified in 75%. Progressive bradycardia preceding the arrest was observed in all but one case. (<i>JAMA</i>1985;253:2373-2377)
Reversal of central anticholinergic syndrome in man by physostigmine
Authors: R. C. Duvoisin
Journal: JAMA (1968)

Physostigmine salicylate in doses of 1 to 2 mg administered parenterally was found to be an effective antidote to intoxication with centrally active anticholinergic agents. Confusion, agitation, hallucinations, stupor, ataxia, dysarthria, and other symptoms were promptly reversed in 26 consecutive patients in whom toxic reactions developed after receiving scopolamine, atropine, or drugs for Parkinson's disease. Physostigmine deserves a place in therapeutics as an antidote to anticholinergic intoxication.
DEDICATION OF THE INSTITUTE FOR BIOMEDICAL RESEARCH
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal