tbuckley/cabot-search huggingface dataset:
Status of the Global Laboratory Network for Poliomyelitis Eradication, 1994-1996
Journal: JAMA (1997)

In 1988, the World Health Assembly adopted the goal of global poliomyelitis eradication by the year 2000. Since then, appropriate strategies have been developed, and substantial progress toward the implementation of these strategies has been reported from each region of the World Health Organization (WHO). The establishment of sensitive surveillance systems to detect polio cases and poliovirus is critical to guide program activities and eventually permit the certification of polio eradication. This report describes the proficiency of the global laboratory network, which operates in each WHO region and provides virologic laboratory support to all countries with endemic polio.
Pharyngeal Gonorrhea
Authors: William O. Harrison
Journal: JAMA (1981)

The continuing pandemic of gonococcal infections in the United States and elsewhere, combined with the increasing frequency of oral-genital sexual activity, necessitates an awareness on the part of clinicians that pharyngeal infections caused by gonococci are no longer unusual occurrences. Tice and Rodriguez report their experiences with gonococcal pharyngitis caused by penicillin-resistant gonococci in this issue (p 2717). Their observations are of significance for several reasons. The first is that penicillinase-producing<i>Neisseria gonorrhoeae</i>(PPNG) appear to be equally well adapted to the pharynx and the urethra. The prevalence data of Tice and Rodriguez indicate that the increase in resistant strains in the Far East, from less than 1% in 1973 to 35% to 50% in 1980, is reflected in pharyngeal as well as genital infection. Their observations show that the various modes of transmission of gonococci from one partner to the other are no different with penicillin-resistant strains than with
Marihuana
Authors: Joseph Stokes
Journal: JAMA (1972)

<h3>To the Editor.—</h3> I was dismayed to read the lead article in the Oct 2,1972 issue ofThe Journalby Kolansky and Moore, and I was further jolted by the associated lead EDITORIAL in the same issue. Not only did they add fuel to the emotional fire regarding the burning issue of the long-term effects of marihuana use, but they also raised the question as to whether or notThe Journalhas become a journal of opinion rather than a journal of fact. In essence, Kolansky and Moore have presented nothing more than 13 distorted anecdotes that do little more than underscore the old adage that a collection of gossip is gossip, nonetheless. The second sentence in their summary that states that "all demonstrated symptoms... disappeared within 3 to 14 months after cessation of drug use" contradicts their description of case 3, since the patient "left town before we could
Making medical messages stick
Authors: E. Wager
Journal: Journal of the Royal Society of Medicine (2007)

Emperaire, an artist and a friend of Paul Ce ´zanne, was born in Aix-en-Provence in 1829, ten years after Ce ´zanne.Little is known about his life.In his early career, he moved frequently between Paris and Aix, working under the influence of the painter Thomas Couture and subsisting on only fifteen francs a month, often by copying pictures in the Louvre. 1 His artistic output was not prolific, but his paintings, particularly his nudes, show a fullness of form, an abundance of curves, and romantic inspiration similar to the works of Delacroix and Seurat.He repeatedly and unsuccessfully tried to exhibit his work at the Salon, the official art exhibition of the Acade ´mie des Beaux-Arts in Paris. 2 Ce ´zanne had an on-off relationship with Emperaire, at times helping him to gain employment, for example as a financial administrator for the Socie ´te ´des Artistes Franc ¸ais in Paris, but he frequently, and cruelly, did not support Emperaire through long periods of financial hardship.However, Ce ´zanne did appreciate his friend's work, and ten years before Emperaire's death in Aix in 1898 he wrote of him in a letter to Gasquet as follows: 'If I had been given the chance to ''realiser'', it is I who should have remained in my corner with some of the studio colleagues with whom we used to go to drink a stein of beer.I still have a good friend from those days; ah well, he didn't succeed, but just the same he was devilishly more painter than the bemedalled and decorated tramps that make one sweat.'
Polypoid and Junctional Squamous Cell Carcinoma of the Tongue and Larynx with Spindle Cell Carcinoma (Pseudosarcoma)
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CBIO-02. MUTANT IDH EXPRESSION DRIVES TERT PROMOTER REACTIVATION AS PART OF THE CELLULAR TRANSFORMATION PROCESS
Authors: Shigeo Ohba, Andrew Mancini, Joydeep Mukherjee, Tor-Christian Johannessen, Tracy Chow, Matthew Wood, Lindsey Jones, Tali Mazor, Roxanne Marshall, Pavithra Viswanath, Yuichi Hirose, Kyle Walsh, Arie Perry, Robert Bell, Joanna Phillips, Joseph Costello, Sabrina Ronen, Russell Pieper
Journal: Neuro-Oncology (2016)

metastases in patients with known previous diagnosis of malignancy(s) from tumors which seldom spread to the nervous system, and dural/epidural masses requiring emergent spinal decompression are more likely to prompt surgical intervention.Metastatic prostatic carcinoma is encompassed in the two latter categories.We reviewed our databases for all cases in which metastatic prostatic carcinoma was strongly clinically suspected and/ or diagnosed at biopsy, 2000-present.As expected 16 cases were dural-based tumors, but 5 were intraparenchymal in pituitary region, right frontal and occipital lobes, cerebellum, right temporal lobe and right thalamus.The latter has been reported only rarely.Conversely, patients with known histories of prostatic carcinoma and suspected metastases were identified having neurocytoma, skull base chordoma, ectopic pituitary adenoma to clival region (detailed in Clin Neuropathol.2012;31(1):24-30), anaplastic meningioma, and undifferentiated malignancies.Two more presented morphologically-challenging diagnoses, including a small cell neuroendocrine variant of prostatic carcinoma and one extremely poorly differentiated with loss of several diagnostic immunohistochemical markers.We conclude that metastatic prostatic carcinoma to the nervous system continues to provide pre-biopsy diagnostic challenges in modern day practice, due to the mixed dural and parenchymal involvement that can be seen, coupled with the frequency with which a diagnosis of previous prostatic carcinoma has been rendered in a patient presenting with new intracranial and/or dural mass(es).Our cohort suggests that intraparenchymal prostatic metastases are likely more frequent than cited incidences.
Long interspersed nuclear element-1 (line-1) hypomethylation is associated with poor outcomes via the activation of ST18 in human hepatocellular carcinoma
Authors: Yu Rim Lee, Gyeonghwa Kim, Hye Won Lee, Se Young Jang, Soo Young Park, Won Young Tak, Young Oh Kweon, Jung Gil Park, Min Kyu Kang, Keun Hur
Journal: Journal of Hepatology (2020)
Central Nervous System
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Alcohol use and psychiatric illness in emergency patients
Authors: D. A. Rund
Journal: JAMA (1981)

Screening for alcoholism and associated psychiatric disorders using preselected research criteria demonstrated an overall prevalence of alcoholism of 20% in 200 emergency department patients. The nighttime prevalence of alcoholism was 29%, while the daytime prevalence was 11%. The psychiatric disorders most frequently associated with alcoholism were primary affective disorder (depression) and antisocial personality. The alcoholics had chief complaints relating to trauma in 63% of the cases, vague neuropsychiatric complaints in 23% of the cases, and complaints directly related to alcohol in 8% of the cases. Screening for alcoholism and associated psychiatric illnesses is important in determining an overall treatment strategy for emergency patients. (<i>JAMA</i>1981;245:1240-1241)
Diabetes
Authors: J. D. N. Nabarro
Journal: BMJ (1967)

tance.McGlashan agrees that such insight points the way to the world of meaning implicit in the primordial images, and these carry an impetus which the futilities of power politics can never subdue.To elevate to the community level the exclusively rational values leads to the highly irrational conclusion of war.In the individual a similar process culminates in neurosis.Primitive force, in unexpected guise, is much in evidence and demands recognition: boys in gaudy clothes with feminine hair- cuts; girls masculine and bizarre as in the masquerade.In such display McGlashan detects the sleeping urge to anarchy that hides in the adolescent-and adult-heart.In contrast stands the calm thinking of static perfection, and that no one seems to want.Our dreams bear witness to iconoclastic impulses which unthinkingly we put aside.In the symbolism of our dreams we enter a savage and beautiful country-the uncon- scious.The actuality of this inner world is widely accepted, though interpretations vary.McGlashan follows Jung, who first called attention to the autonomy of the unconscious and sought to chart its landmarks.With expectation the hope is expressed of a new direction and delicacy of perception of as high an order as that needed for scientific research.This original approach to the significance of the unconscious will have a wide appeal, and not least to psychiatrists concerned with analytical work.
A phase I study of vorinostat in combination with bortezomib in refractory solid tumors
Authors: W. R. Schelman, J. Kolesar, K. Schell, R. Marnocha, J. Eickhoff, D. Alberti, G. Wilding, H. Bailey
Journal: Journal of Clinical Oncology (2007)

3573 Background: Vorinostat (suberoylanilide hydroxamic acid, SAHA) is a histone deacetylase (HDAC) inhibitor that has anti- tumor activity in hematologic malignancies and advanced solid tumors. Based on studies showing that HDAC inhibitors increase the activity of the 26S proteasome, vorinostat has been postulated to act synergistically with bortezomib. This study was conducted to determine the toxicities and efficacy of vorinostat with bortezomib. Correlative studies included pharmacokinetics and the effects of vorinostat/bortezomib on cell cycle, proteasome inhibition, histone acetylation, gene expression and apoptosis. Methods: This study used standard eligibility criteria except pts must have had no prior bortezomib. The treatment plan consisted of vorinostat given orally on days 1–14 with bortezomib IV on days 1, 4, 8 and 11 of a 21-day cycle. Starting dose (Step A, level 1) was once-daily vorinostat (400 mg) and bortezomib (0.7 mg/m 2 ). Step B consisted of twice-daily dosing of vorinostat (200mg) with bortezomib at MTD established in Step A. RECIST was used to measure response. Effects on G2/M-phase arrest in buccal mucosa cells (BMC) were measured using flow cytometry. Samples were collected on days 1 and 9, at 0, 2 and 4 hr following treatment. Results: 22 pts have been enrolled; 14 men, 8 women. Tumor types: 5 sarcoma, 5 colorectal, 3 pancreatic, 2 lung, 1 breast, 1 ovarian, 1 bladder, 1 gastric, 1 germ cell, 1 mesothelioma, 1 GIST. Grade 3–4 toxicities at least possibly related to vorinostat at any dose level were as follows: fatigue (3), n/v (1), thrombocytopenia (1), and hyponatremia (1). One pt was unevaluable. DLTs included fatigue (3), hyponatremia (1) and elevated ALT (1). The MTD for Step A was established at vorinostat 400mg daily and bortezomib 1.3 mg/m 2 . One pt with refractory soft tissue sarcoma had a PR &gt; 9 mo. There was no effect on cell cycle arrest observed with vorinostat in BMCs. Conclusions: The MTD for Step A was established at vorinostat 400mg daily and bortezomib 1.3 mg/m 2 . Accrual continues at Step B, dose level 1. Subjective and objective evidence of clinical activity has been observed in pts with refractory solid tumors. (Supported by NCI grant UO1 CA062491, NCI SAIC contract 25XS097 and GCRC M01 RR03186.) No significant financial relationships to disclose.
Fluroxene anesthesia for pheochromocytoma removal
Authors: T. A. Joas
Journal: JAMA (1969)

In 1951 Apgar and Papper stated, "There appears to be no agreement in the literature on the most desirable means of anesthetic management for pheochromocytoma excision."<sup>1</sup>This statement applies equally well today, even with better understanding of the autonomic nervous system<sup>2</sup>and the concept of alpha- and beta-adrenergic receptors and blockers.<sup>3</sup>Concomitant with development of adrenergic pharmacology has been the introduction of the halogenated anesthetic agents, halothane, methoxyflurane, and fluroxene. The literature is replete with reports of pheochromocytoma removal utilizing alpha- and beta-adrenergic blockade in conjunction with many general anesthetic agents.<sup>4-6</sup>Halothane is a popular general anesthetic agent and has both advocates<sup>4</sup>and opponents<sup>7</sup>concerning its use alone or with other drugs. Several reports have described the use of methoxyflurane for the removal of pheochromocytoma,<sup>8,9</sup>but, to our knowledge, there is only one published instance of fluroxene anesthesia for pheochromocytoma removal.<sup>10</sup> We have
Missed linkage to care for patients with chronic hepatitis C virus infection in a tertiary care center: results of the telepass project
Authors: Francesca Ponziani, Francesco Santopaolo, Massimo Siciliano, Antonio De Belvis, Annalisa Tortora, Vincenzina Mora, Caterina Fanali, Alisha Morsella, Fulvio Balducci, Giuseppe Vetrugno, Maria Elena D’Alfonso, Andrea Cambieri, Roberto Cauda, Rocco Bellantone, Maurizio Sanguinetti, Maurizio Pompili, Antonio Gasbarrini
Journal: Journal of Hepatology (2020)
Casopis Lekaru Ceskych, Prague
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Possible Interrelations among Environmental Toxicants, Amphibian Development, and Decline of Amphibian Populations
Authors: Cynthia Carey, Corrie J. Bryant
Journal: Environmental Health Perspectives (1995)

Many amphibian populations are declining in a number of geographical locations throughout the world.In most cases, the cause or causes are unknown, but are assumed to result from man-made alterations in the environment.We review existing evidence concerning how environmental xenobiotics could contribute to declines of amphibian populations by impacting growth and development of the young.This paper examines the potential roles of toxicants in: a) affecting the susceptibility of young to disease; b) retarding growth and development of amphibian young; c) affect- ing the ability of larvae to avoid predation; d) affecting the development of physiological, morphological, or behavioral processes in a manner that subsequently impairs the ability of the young for future reproduction; and e) directly causing mortality of young.These issues are not well studied, and more studies are needed before the roles of environmental xenobiotics in amphibian declines are fully understood.
Soft Tissue Sarcoma: Review of 200 Cases
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Glasgow Royal Maternity and Women's Hospital. Medical Report for the Year 1931.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dehydration Fever
Authors: S. McDermott
Journal: BMJ (1943)

MEDICALTIJIURNAL 455 _~~~~~~~~~~EIA ORA treatment personally two fersolate tablets were given thrice daily till a normal count was attained.In Table lI the details of the gastric analysis are given.TABLE II.-Fractional Test Meals.(Cases 1, 6, 7, 8, and 9 showed comnplete achlorhydria) Specimens (hours) Case--.Fasting i
PARIS
Journal: JAMA (1931)

<h3>Cancer and Magnesium in the Soil</h3> Professor Delbet is carrying on research on the relation that he alleges exists between the dearth of magnesium in the soil and the development of cancer. He stimulates research by other investigators and publishes results that appear to confirm his thesis. He presented recently to the Academy of Medicine the results of the research of Dr. Robinet of Moret. The latter prepared statistics on cancer mortality in the small rural communes with less than 5,000 inhabitants, who live directly from the soil. He then made investigations to determine the magnesium content of the French soil. He presented two maps, one showing the distribution of magnesium and the other the relative incidence of cancer. The relationship between the two maps is striking. Of the twenty-five districts with a very low cancer incidence, twenty-four have a soil with a high magnesium content. Of the twenty-four districts
RETROPERITONEAL PERIRENAL LIPOMAS
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal