tbuckley/cabot-search huggingface dataset:
Concurrent chemoradiotherapy of twice weekly paclitaxel and cisplatin followed by esophagectomy for locally advanced esophageal cancer
Authors: C.-H. Hsu, C.-C. Lin, K.-H. Yeh, J. C. Chen, L.-L. Ting, J.-M. Lee, Y.-C. Lee, H.-P. Wang, J.-T. Lin, A.-L. Cheng
Journal: Journal of Clinical Oncology (2004)

4033 Background: Concurrent chemoradiotherapy (CCRT) followed by surgery has recently become a promising treatment for esophageal cancer. Twice weekly chemotherapy using paclitaxel & cisplatin was a potentially highly active regimen for esophageal cancer (Lokich JJ, et al. Cancer 1998;34:659). The pilot part of this study had been reported (Proc Am Soc Clin Oncol 21:132b, 2002 [abstr 2340]). In this study, we incorporated the twice weekly paclitaxel & cisplatin regimen into CCRT. Methods: Between Feb 2000 & Dec 2003, 50 patients (13 pilot, 37 phase II) (median age: 56 yrs, range 41–76 yrs; M : F = 44 : 6) with locally advanced esophageal squamous cell carcinomas (T3 or N1) were enrolled. The CCRT regimen included paclitaxel (35 mg/m2 1hr infusion, Mon & Thu), cisplatin (15 mg/m2 3hr infusion, Tue & Fri), and radiotherapy (2 Gy/day, Mon to Fri). When accumulated radiation dose reached 40 Gy, all patients were evaluated for the feasibility of esophagectomy. For patients who were not feasible for esophagectomy, CCRT was continued to a dose of 60 Gy. Results: The average given / planned dose of paclitaxel & cisplatin was 86% & 84%, respectively. 5 patients are still under the protocol treatment now. 2 patients died of ruptured aorto-esophageal fistula during CCRT. 18 patients were not suitable for esophagectomy. 10 of these 18 patients achieved clinical complete response (CR). The pathological CR of 25 patients who underwent esophagectomy was 36% (9/25) (95% CI: 16 – 55%). 2 patients died of hepatic failure & invasive fungal infection, 25 & 114 days after esophagectomy, respectively. 16 of the remaining 23 patients were relapse-free until Dec 2003 with a median follow up of 24 months. The median survival of the whole group has not been reached (range: 0.5–20+ months) and 1-year survival was 59%. Grade 3/4 leukopenia & thrombocytopenia developed in 12/50 & 8/50 patients, respectively. Sepsis occurred in 8/50 patients. Grade 3/4 non-hematologic toxicity was seen in 16/50 patients. Conclusion: CCRT with twice weekly paclitaxel & cisplatin regimen followed by esophagectomy is highly active in the treatment of locally advanced esophageal cancer. No significant financial relationships to disclose.
Symposium on Immunodeficient Animals in Cancer Research
Journal: JNCI Journal of the National Cancer Institute (1979)

Symposium on Immunodeficient Animals in Cancer Research Get access JNCI: Journal of the National Cancer Institute, Volume 62, Issue 1, January 1979, Page 213, https://doi.org/10.1093/jnci/62.1.213b Published: 01 January 1979
Nutrition Therapy Recommendations for the Management of Adults With Diabetes
Authors: Alison B. Evert, Jackie L. Boucher, Marjorie Cypress, Stephanie A. Dunbar, Marion J. Franz, Elizabeth J. Mayer-Davis, Joshua J. Neumiller, Robin Nwankwo, Cassandra L. Verdi, Patti Urbanski, William S. Yancy
Journal: Diabetes Care (2013)
Medical Education
Authors: C. Holman
Journal: BMJ (1900)

and not spirits.The association of pigmentation in many cases occurring suddenly and rapidly, completely covering the whole body, the occurrence of eruptions and soreness of the eyes, pointed to the suggestion that there was some poisonous agent in the food or drink, and a new light has been thrown upon the matter by Dr. E. S. Reynolds of Manchester who has actually found arsenic in samples of beer.
Scleredema "Adultorum" in Children: Report of Three Cases With Histochemical Study and Review of World Literature
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Breast Cancer Screening Guidelines Agreed On by AMA, Other Medically Related Organizations
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Law of the Morphology or Metamorphosis of the Textures of the Human Body
Authors: W. Addison
Journal: BMJ (1847)

Scrofula is the term used to designate a particular state or condition of the living body, rendered apparent by the phenomena of its nutrition and diseases.The term, whatever may have been its origin, seems like many others in medical science, to have been handed down with reference to the buman structure for con- venience sake, rather than for any other reason.Writers upon the subject of scrofula, for the most part, reiterate one after another certain external appearances in the general contour of the person-in the eyes, lips, nose, countenance, or complexion, bv which they say those individuals who are scrofulous may be distinguished from otbers who are not so.But we shall hereafter sbew that no satisfactory practical distinctions can be safely made upon such grounds, the constitutional disposition not declaring itself until the qualities of the textures, and their capacity of withstanding injurious iufluences, have been tested and declared by some irritating or disturbing cause, giving rise to an unusual local increase of nutritive matter; when the form of the morphology or meta- rnorphosis-the conformable or unconformable type of the changes-pronounces the constitutional diatbesis.If there be one fact better established than others in respect of scrofula and scrofulous diseases, it is their hereditary character, the offspring exhibiting
Study of 93 Cases of Renal Injury Due to Gunshot Wound
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 19981: Relationship of Cardiorespiratory Fitness and Adiposity With Left Ventricular Peak Systolic Strain in Middle-age Adults: The Dallas Heart Study
Authors: Ambarish Pandey, Colby Ayers, Ian J Neeland, Susan Matulevicius, Anand Rohatgi, Ronald Peshock, Mark Drazner, Satyam Sarma, James De Lemos, Jarett D Berry
Journal: Circulation (2015)

Introduction: Low cardiorespiratory fitness (CRF) and obesity are associated with an increased risk for heart failure (HF). However, the mechanisms through which CRF and adiposity might increase HF risk are not fully understood. Because impaired left ventricular (LV) peak systolic strain is an early subclinical marker of HF, we evaluated the association of CRF and adiposity with LV peak systolic strain. Methods: We studied Dallas Heart Study-II participants without cardiovascular disease who had CRF estimated as the peak oxygen uptake from a submaximal treadmill test using the Givoni’s equation and Hellerstein’s formula and total body fat measured by dual x-ray absorptiometry. The participants also had ECG-gated tissue-tagged cardiac MRI imaging using 3-T MRI. Peak mid-wall systolic circumferential strain (Ecc) was determined by harmonic phase imaging. Associations of CRF and measures of overall adiposity [percent body fat (%BF)] and visceral adiposity [waist circumference (WC)] with Ecc were determined using multivariable adjusted linear regression analysis. Results: A total of 1,493 participants (57% women, 42% African Americans) were included in the analysis. After adjustment for baseline risk factors, higher LV mass (β = 0.17; P&lt; .0001), lower ejection fraction (β = -0.32; P = &lt; .0001), higher hs-cTnT levels (β = 0.06; P= 0.04), and lower CRF (β = -0.16; P&lt; .0001) were each associated with higher Ecc (indicating worse systolic function). Higher WC was also significantly associated with higher Ecc (β = 0.07; P= .0006) while %BF was not associated with Ecc (P= 0.08). The relationship between CRF and Ecc did not change after additional adjustment for %BF and other significant confounders (Table). Conclusion: Lower CRF, but not total body fat, is associated with reduced peak systolic strain independent of LV mass and ejection fraction.These findings highlight the independent contributions of low fitness in mid-life towards heart failure risk at a later age.
Supraventricular Tachycardias
Authors: Delon Wu
Journal: JAMA (1983)

SUPRAVENTRICULAR tachycardia is a common clinical arrhythmia, occurring in patients with and without heart disease. The attacks of tachycardia are characterized as paroxysmal, being of sudden onset and abrupt termination, and occurring without a period of gradual acceleration in rate. The rate of tachycardia is usually around 150 to 220 beats per minute. The episode is usually initiated by premature atrial and/or ventricular beats. During tachycardia the QRS complex manifests a regular RR interval and is of normal duration unless bundle-branch block is present. When visible, the morphology of the P wave is different from that of the sinus P wave and may occur before, simultaneously with, or after the QRS complex. Vagal maneuvers frequently terminate the tachycardia. Reentry is the mechanism of tachycardia in most patients, while in some patients the mechanism may be due to enhanced automaticity. The classification, diagnosis, and management of supraventricular tachycardia are discussed in
Synthetic and Oxidative Studies on 8-(Arylamino)-2 prime -Deoxyguanosine and -Guanosine Derivatives
Authors: Francis Johnson, Chin-Yi Huang, Pei-Lin Yu
Journal: Environmental Health Perspectives (1994)

Facile aerial oxidation is a general feature of guanine ribo-and 2'-deoxyribonucleosides that are substituted at the 8-position by an aminoaryl group.In previous work, it had been suggested that two of the major oxidation products are a pair of diastereomers having a spiro structure.These were presumed to be related by a chiral difference at the spiro carbon atom.The pattern of the oxidative process involves a contraction of the pyrimidine ring.It was thought to be analogous to that suggested by other investigators for the oxidation of uric acid, but for which no really definitive evidence had been presented.We have been able now to isolate in a crystalline state one of the diastereomers produced by the aerial oxidation of 8-phenyl- aminoguanosine under alkaline conditions.Analysis by X-ray diffraction has now confirmed the type of spiro structure promulgated previously.These findings also imply that spiro compounds are likely to be produced during the aerial oxidation of any 8-arylaminoguanine nucleoside or 2'-deoxynucleoside.In addition, this work adds considerable weight to the results of Poje and Sokolic-Maravic who proposed that a spiro intermediate is produced during the aerial oxidation of uric acid (12,13).However, they found this compound to be unstable to base, in contrast to the arylaminoguanine oxi- dation products.In the course of the above work we showed that the 8-arylamino derivatives of guanosine can be converted by the Barton deoxy- genation method to the corresponding 2'-deoxyribonucleosides.This makes available a number of the latter compounds, which are not easily prepared by other methods.-Environ Health Perspect 102(Suppl 6): 143-149 (1994)
THE TURKISH BATH AS A REMEDY.
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Recommendations for Waste Disposal of Phosphorus-32 and Iodine-131 for Medical Users.
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Disseminated aspergillosis in a presumably immunocompetent host
Authors: H. D'Silva
Journal: JAMA (1982)

Disseminated aspergillosis was found in an apparently healthy man. Although he had a history of diabetes and recent alcohol ingestion, there was no pathological evidence of diabetes mellitus or cirrhosis at autopsy. (<i>JAMA</i>1982;248:1495-1497)
Sponsor Omitted
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Maintaining vigilance over quality of EU research
Authors: None The Lancet
Journal: The Lancet (1999)

3 weeks ago the European Union faced its worst crisis in its 42 years. All 20 commissioners resigned in the wake of a report of corruption and mismanagement at the European Commission. Among the allegations, largely of financial irregularities and nepotism, was the appointment by Edith Cresson, the Research and Education Commissioner, of her dentist friend to supervise an EU project on AIDS.
Some Like It Hot!
Authors: Bruce D. Cheson
Journal: Journal of Clinical Oncology (2001)

Article Tools EDITORIAL Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2001.19.19.3908 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 11579110 Some Like It Hot! Bruce D. ChesonxBruce D. ChesonSearch for articles by this author Show More National Cancer Institute, Bethesda, MD https://doi.org/10.1200/JCO.2001.19.19.3908 First Page Full Text PDF Figures and Tables © 2001 by American Society of Clinical Oncology
Guanase Activity in Normal and Neoplastic Human Tissue
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE CHIROPRACTIC THEORY OF LAW
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Is This Patient Pregnant?
Authors: Lori A. Bastian
Journal: JAMA (1997)

This review addresses a common problem facing the clinician: "When treating or evaluating a woman of childbearing years, what is the value of historical or physical examination features in determining the probability of early pregnancy?" We focus on the clinical examination findings that may help the clinician rule in or rule out early pregnancy. Generally accepted indicators of pregnancy include amenorrhea, morning sickness, tender or tingling breasts, and, after 8 weeks' gestational age, an enlarged uterus with a soft cervix. We reviewed the value (ie, sensitivity and specificity) of these indicators, as well as home pregnancy test results, as predictors of the diagnosis of early pregnancy. The available evidence suggests that some historical features, when absent, are fair but not reliable for ruling out pregnancy. When diagnosing early pregnancy, the clinician should not rely on the clinical examination or a home pregnancy test—a laboratory test should be requested.