tbuckley/cabot-search huggingface dataset:
Postpartum acquired factor VIII inhibitors: results of a survey
Authors: Susan Solymoss
Journal: American Journal of Hematology (1998)

Postpartum factor VIII inhibitors are rare; thus, collecting clinical and treatment data may provide valuable information in guiding patient management. This paper reports the results of a survey of United States and Canadian hemophilia centers on 14 patients with postpartum acquired factor VIII inhibitors. Patients ranged in age from 23 to 40 years. Parity at diagnosis was most frequently the first gestation. Two patients were diagnosed prepartum, but two patients only up to one year postpartum. Initial inhibitor titers ranged from two to 550 Bethesda units (BU), and rose to five to 885 BU. The median duration of the inhibitor was 27 months, with two of the 14 inhibitors unresolved at the time of the survey. A total of 80 bleeding episodes occurred, five of which were life or limb threatening. Three patients received no blood products and were not hospitalized. Of those treated for hemostasis, activated prothrombin complex concentrates and porcine factor VIII were most often reported to be effective. For immunosuppression, all patients received steroids and most received additional treatment. Steroids were reported ineffective more frequently than cyclophosphamide. No adverse fetal events were noted and there was no maternal mortality. These results underline the clinical heterogeneity of the severity of postpartum factor VIII inhibitors, and provide treatment guidelines in the absence of prospective studies. Am. J. Hematol. 59:1–4, 1998. © 1998 Wiley-Liss, Inc.
Role of dactinomycin in the improved survival of children with Wilms' tumor
Authors: D. J. Fernbach
Journal: JAMA (1966)

Thirty consecutive cases of histologically proved Wilms' tumor followed for a minimum of two years have been reviewed. The overall survival rate was 70%, with 47% beyond the period of risk (Collins'). Of 14 children treated by nephrectomy and postoperative radiotherapy, 43% (6 of 14) are living and apparently free of tumor. Of 13 children treated with dactinomycin in addition to nephrectomy and postoperative radiotherapy, 92% (12 of 13) are living and apparently free of tumor. It was concluded that the survival of children with Wilms' tumor is markedly prolonged by the administration of dactinomycin at the time of diagnosis. The beneficial effect of dactinomycin was attributed to the "cidal" action of this drug on small or poorly established metastases.
WORKSHOP: H PYLORI - MICROBIOLOGY AND GENETICS
Authors: N Akopyants, D Kersulyte, D Bm
Journal: Gut (1995)

Most Helicobacter pylori strains implicated in peptic ulcers and gastric cancer produce a vacuolating cytotoxin and an immunodominant cytotoxin-associated protein, encoded by the vacA and cagA genes, respectively.In contrast, many strains from asymptomatic carriers do not produce either protein.We searched for new genes associated with virulence using our ordered library of H. pylori cosmid clones (Molec.Micro. 11:509-523, 1994), and by hybridizing restriction digests of each cosmid with DNA from several cagAand control cagA+ strains.A -21 kb segment was found that was present only in the cagA+ strains.We propose that it be called "cagIIr, for "second cytotoxin-associated gene" segment.Most of cagII was cloned as a set of seven BglII fragments, which were also used as hybridization probes.They hybridized with DNAs from each of 73 cagA+ strains, but not with DNAs from 32 of 33 cagA-strains.The left end of cagIl in our type strain (NCTC1 1638) was mapped; PCR primers specific for that end and for adjacent sequences were then constructed to assess whether cagII tends to occur at one site, or at many locations (e.g. as with typical transposons).These primers allowed amplification of a -300 to ~500 bp product from each of 15 cagII+ strains tested, but gave no product with any of 15 cagll-controls.Thus, the cagIlI location is constant in most cagII+ strains; there is also some diversity among strains in cagII terminal sequences and/or adjacent chromosomal DNA.Further analysis of cagII ends and corresponding regions in cagI-strains should help us learn how cagII is gained or lost from its unique site during evolution.Our mapping showed that cagII is far from vacA and cagA in the H. pylori genome.Accordingly, we propose that the association of these three loci reflects joint selection for their various functions, not chromosomal linkage.In parallel studies, the DNA sequence of caglI has been determined and is being analysed (S.Clifton et al., this meeting), in the expectation that some cagll-encoded proteins will be important in host interactions during infection --perhaps as mediators of tissue damage, of immune or inflammatory responses, or of cellular proliferation.
THE LAST WORD IN MICROSCOPES
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hepatology Highlights
Authors: Zaid H. Tafesh, Robert S. Brown, Joseph F. Pisa, Robert E. Schwartz, Russell Rosenblatt, Nicholas Russo, Nicole T. Shen, Shawn Shah, Amit Mehta, Vikas Gupta
Journal: Hepatology (2018)

Tafesh, Zaid H.; Brown, Robert S. Jr.; Pisa, Joseph F.; Schwartz, Robert E.; Rosenblatt, Russell; Russo, Nicholas; Shen, Nicole T.; Shah, Shawn; Mehta, Amit; Gupta, Vikas Author Information
Guanethidine
Authors: Jan Koch-Weser, Raymond L. Woosley, Alan S. Nies
Journal: New England Journal of Medicine (1976)

Although guanethidine has been available for treatment of hypertensive patients for more than 15 years, sufficient recent data are available so that it is appropriate to review the current use of the drug and its role in the management of hypertension.Mechanism of ActionGuanethidine has actions that are uniquely targeted to the peripheral sympathetic nervous system. Its selective action results from the fact that the drug is a substrate for the pump that transports norepinephrine into the nerve ending. Guanethidine is actively transported into the neuron by this "norepinephrine pump"; inhibition of the norepinephrine pump also inhibits guanethidine uptake . . .
ESSENTIAL HEMATURIA
Authors: Edgar G. Ballenger
Journal: JAMA (1933)

<h3>To the Editor:</h3> —InThe Journal, April 1, page 1076, is an abstract of an article on essential hematuria, by Löfberg. In reference to the treatment of this condition, the statement is made that "of the various operative procedures, nephrectomy best meets the indications." Löfberg reports eight cases observed in the course of ten years at the General Hospital at Malmö, Sweden. A nephrectomy was performed in seven. During the past seventeen years I have seen ten patients with hematuria in whom no lesion could be found to account for the profuse bleeding. Ureteral strictures were among the disorders suspected as causative factors and were excluded by the usual urologic methods. Yet, in all of these patients, dilation of the ureters was followed by cessation of blood. From one to three dilations were required, according to the size of the catheters introduced and the length of time they were retained.
Hematology
Authors: Joseph M. Baron
Journal: JAMA (1986)

The latest (fourth) edition of Beck's<i>Hematology</i>carries on the tradition of earlier versions. Its aim is to provide medical students and those interested in reviewing a rapidly moving, diverse field with up-to-date lecture-chapters by multiple experts in a carefully edited outline format. The major emphasis is on pathophysiology, with only cursory attention given to principles of management. The text is liberally sprinkled with excellent diagrams, tables, and illustrations. The information is presented in a condensed but quite readable form. A limited number of key references are included after each lecture. The expansion and updating of lectures on lymphoma, leukemia, and coagulation complements the traditionally strong coverage of red blood cell topics. This book achieves its stated goals and more. It is a welcome addition to the internist's or hematologist's library.
Error in Reference.
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Acute pulmonary embolism: mortality prediction by the 2014 European Society of Cardiology risk stratification model
Authors: Cecilia Becattini, Giancarlo Agnelli
Journal: European Respiratory Journal (2017)

The correspondence by S. Ozsu concerns several issues. The first issue is the identification of low-risk patients with acute pulmonary embolism. According to the 2014 European Society of Cardiology (ESC) guidelines, a Simplified Pulmonary Embolism Severity Index (sPESI) score of zero efficiently identifies patients at low risk for death; assessment of right ventricle dysfunction by imaging or biomarkers is optional in patients with sPESI 0 [1]. Our study reports a simulation of what would happen in clinical practice by adopting the risk stratification model proposed by the 2014 ESC guidelines (see table 2 of our article) [2]. Patients at low risk (sPESI 0) would not undergo assessment of right ventricle dysfunction by imaging or biomarkers. The warning here is that ∼40% of these patients have right ventricle dysfunction at imaging and ∼30% of them have increased troponin levels [2]. Are these abnormalities of clinical value? It depends on the clinical relevance of the 0.5% observed 30-day mortality. In our opinion, 0.5% mortality at 30 days does not justify the mandatory assessment of right ventricle dysfunction and biomarkers in all patients with sPESI 0. However, we believe that right to left ventricle dimension ratio should be evaluated and reported for all patients who have computed tomography angiography for the diagnosis of pulmonary embolism [3]. This assessment will help clinicians to properly select low-risk patients (sPESI 0 and no right ventricle dilation) without performing any additional test. Further studies are needed to improve risk stratification in acute pulmonary embolism at intermediate risk for death <http://ow.ly/BYZo304vmUy>
Masthead
Authors: Bennett Blitzer, Francis Chisari, La Jolla, California Jayanta, Roy Chowdhury, New York, Sheila Cohen, New Jersey, Jules Dienstag, John Farber, Michael Gerber, Ellen Gordon, Carl Goresky, Canada Montreal, Virginia Richmond, G William, San Hardison, Alan California, San Hofmann, Jay California, Maryland Bethesda, G Kamal, Washington Ishak, D Albert, L Jones, San Francisco, California Jones, Maryland Kaplan, Neil Boston, Los Kaplowitz, Ralph California, Cape Kirsch, South Town, Richard Africa, Maryland Bethesda, F Nicholas, Rochester Larusso, Minnesota Lauterburg, Roger Lester, M Phillips, Lawrie Powell, Robert Purcell, Maryland Lola, Reid York, Telfer Reynolds, David Schachter, Steven Schenker, Antonio San, Daniel Texas, Francis Simon, Clifford Denver, Maryland Bethesda, San Stem, Irmin Francisco, New Sternlieb, Anthony Tavill, Howard Cleveland, John Thomas, Jack Denver, John Boston, Herbert Watkins, W Allan, New Wolkoff, George York, Hyman Zimmerman
Journal: Hepatology (1985)
European Perspectives
Journal: Circulation (2012)

It Was Catastrophic.We Lost 700 Cages of Mice, and Key Projects Had to Be Abandoned" Few weather events can be said to have played a part in groundbreaking medical research, but one that did was Allison, the major US tropical storm that wandered its way up from the Gulf of Mexico in June 2001.Despite never reaching hurricane force, it impacted massively on the states of Texas and Louisiana.In places as much as 40 inches (1 metre) of rain fell.Downtown Houston, TX, was particularly badly affected, with extensive flooding that made thousands of people homeless and destroyed many buildings, including some on university and medical campuses.One of those who watched on helplessly, knowing that years of painstaking research had been decimated, was Professor Schneider.In the previous year, he had been appointed to the MD Anderson Foundation Chair at Baylor College of Medicine, Houston, 7 years after arriving in Houston as an assistant professor.During this time, he had led teams of researchers investigating the molecular biology and cell biology of the heart, with an emphasis on the mechanisms that control the growth and development of f91
Thrombocytosis
Authors: Andrew I. Schafer
Journal: New England Journal of Medicine (2004)

Thrombocytosis is usually discovered incidentally, but the differential diagnosis is important. In cases of reactive, or secondary, thrombocytosis, the underlying disease may require treatment. Clonal thrombocytosis, in contrast, is associated with both thrombotic and bleeding complications, and cytoreductive treatment may be necessary. This review also summarizes the current understanding of platelet production.
Maternal age and births in the 1980s
Authors: M. M. Adams
Journal: JAMA (1982)

Projections from the US Bureau of the Census show that as the large "baby boom" cohort ages in the 1980s, the percentage of births to women 35 years or older will increase by 37%, while the percentage of births to teenaged women, the small post-baby-boom cohort, will decrease by 32%. Between 1980 and 1990, for women aged 35 to 44 years, fertility rates are projected to increase modestly, whereas for teenagers aged 15 to 19 years, fertility rates are projected to decrease modestly. Assuming that half of pregnant women aged 35 years or older request prenatal chromosomal diagnosis, an estimated 1.1 million pregnant women aged 35 years or older will request this service during the 1980s, increasing substantially the demand for it. Simultaneously, demand for prenatal care for teenagers will decrease, due to the decrease in births to teenagers. (<i>JAMA</i>1982;247:493-494)
A phase II study of weekly docetaxel (T) and capecitabine (X) in patients with metastatic gastric cancer (GC)
Authors: H. K. Kim, J. H. Chun, J. S. Lee, J. Y. Choi, H. G. Lee, I. J. Choi, K. W. Ryu, Y.-W. Kim, J. S. Lee, J.-M. Bae
Journal: Journal of Clinical Oncology (2004)

4057
THE BARRING OF CONSUMPTIVE HEALTH-SEEKERS.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Evidence for a Dose-Dependent Inflammatory Response to Quartz in the Rat Lung and Its Significance in Early Changes in Collagen Metabolism
Authors: S. E. Sykes, A. Morgan, S. R. Moores, S. T. Jones, A. Holmes, W. Davison
Journal: Environmental Health Perspectives (1983)

The response of the rat lung to a range of doses of quartz at 50 and 100 days after its administration by intratracheal instillation has been assessed by bronchopulmonary lavage. The effects on the number of polymorphonuclear leukocytes (PMN), lymphocytes and macrophages are described. In addition the concentrations of soluble protein and hydroxyproline and the activities of lactate dehydrogenase, PZ peptidase and collagenase in lavage fluid supernatants were measured and an assessment of the hydroxyproline content of recovered cells was made. Finally PZ peptidase and collagenase were assayed in PMN-enriched cell fractions and in samples obtained from short-term culture of recovered macrophages. There was a dose-dependent increase in the recovery of all three cell types, and in the amounts of lactate dehydrogenase, protein and hydroxyproline in lavage fluids, which showed no signs of resolution over the 100-day period studied. Measurements of PZ peptidase and collagenase suggested that the PMN, not the macrophages, are the major source of these degradative enzymes. The relevance of these findings with regard to the importance of PMN in quartz-induced fibrosis is discussed.
A randomized, open-label, phase 2 study of everolimus in combination with pasireotide LAR or everolimus alone in advanced, well-differentiated, progressive pancreatic neuroendocrine tumors: COOPERATE-2 trial
Authors: M.H. Kulke, P. Ruszniewski, E. Van Cutsem, C. Lombard-Bohas, J.W. Valle, W.W. De Herder, M. Pavel, E. Degtyarev, J.C. Brase, L. Bubuteishvili-Pacaud, M. Voi, R. Salazar, I. Borbath, N. Fazio, D. Smith, J. Capdevila, R.P. Riechelmann, J.C. Yao
Journal: Annals of Oncology (2019)

Ann Oncol 2017; 28(6): 1309–1315 (doi: 10.1093/annonc/mdx078) The following funding information has been added: “This work was supported in part by The University of Texas MD Anderson Cancer Center Support Grant P30 CA016672.” A randomized, open-label, phase 2 study of everolimus in combination with pasireotide LAR or everolimus alone in advanced, well-differentiated, progressive pancreatic neuroendocrine tumors: COOPERATE-2 trialAnnals of OncologyVol. 28Issue 6PreviewSeveral studies have demonstrated the antitumor activity of first-generation somatostatin analogs (SSAs), primarily targeting somatostatin receptor (sstr) subtypes 2 and 5, in neuroendocrine tumors (NET). Pasireotide, a second-generation SSA, targets multiple sstr subtypes. We compared the efficacy and safety of pasireotide plus everolimus to everolimus alone in patients with advanced, well-differentiated, progressive pancreatic NET. Full-Text PDF Open Archive
Editorial Board
Authors: Samuel Didier, Christopher Day, Peter Galle, Richard Moreau, Thomas Baumert, Pierre-Alain Clavien, Derek Mann, Fabio Marra, Philippe Mathurin, Vincenzo Mazzaferro, Jorg Petersen, Robert Schwabe, Stefan Zeuzem, Scott Friedman, Daniel Shouval, Graeme Alexander, Josep Llovet, Detlef Schuppan, Raphael Porcher, Sheila Sherlock, Gustav Paumgartner, Simona Negrini, Esther Dohmann, Joe ¨l Walicki, Laurence Zulianello, Juan Abraldes, Canada Ackerman, Israel Zvi, Simon Afford, U Alberti, Italy Alpini, Usa Gianfranco, Usa Paul, Quentin Anstee, Ben-Ari Ziv, Israel Berg, Germany Thomas, Antonio Bertoletti, Austria Forner, Spain Forns, Garcia-Paga Xavier, Juan ´n, Garcia-Tsao Carlos, Usa Geier, Germany Gine, Spain Gores, Usa Gregory, Italy Laura, Zakiyah Kadry, Usa Kaneko, Japan Shuichi, Jia-Horng Kao, Taiwan Kaplowitz, Italy Mieli-Vergani, U Giorgina, Satdarshan Monga, Usa Moshage, O Grady, Oude Elferink, Sweden Wiest, Germany Reiner, Chau-Ting Yeh, Taiwan Zarsky, France Zuckerman, Israel Governing, Markus Peck-Radosavljevic, Laurent Castera, France Treasurer, Mauro Bernardi, Matı ´as, A Avila, Frank Lammert, Germany Helen, Louise Reeves, Alessio Aghemo, Cecilia Rodrigues
Journal: Journal of Hepatology (2013)
Risk factors for hypoglycemia associated with pentamidine therapy for Pneumocystis pneumonia
Authors: H. Waskin
Journal: JAMA (1988)

In 1984, three patients died of severe hypoglycemia after receiving pentamidine isethionate to treat<i>Pneumocystis</i>pneumonia. These deaths occurred on days 8,12, and 19 of treatment, respectively. To assess risk factors associated with pentamidine treatment and hypoglycemia, we reviewed records of patients treated with pentamidine in New York City in 1984; ninety-seven percent of these patients had a diagnosis of acquired immunodeficiency syndrome. Hypoglycemia occurred in 23 (14%) of 164 patients. Hypoglycemia was more likely to occur in patients who received therapy of longer duration and an increasing dosage of pentamidine. Patients at greater risk for hypoglycemia also included those who had received pentamidine previously and those who experienced azotemia during treatment. This serious, potentially fatal, reaction should be considered in all patients who are treated with pentamidine, particularly those receiving prolonged or recurrent therapy. (<i>JAMA</i>1988;260:345-347)
SIR HENRY HEAD (1861-1940)
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal