tbuckley/cabot-search huggingface dataset:
DNA damage is a novel response to sublytic complement C5b-9–induced injury in podocytes
Authors: Jeffrey W. Pippin, Raghu Durvasula, Arndt Petermann, Keiju Hiromura, William G. Couser, Stuart J. Shankland
Journal: Journal of Clinical Investigation (2003)

In response to Ab-complement–mediated injury, podocytes can undergo lysis, apoptosis, or, when exposed to sublytic (<5% lysis) amounts of C5b-9, become activated. Following the insertion of sublytic quantities of C5b-9, there is an increase in signaling pathways and growth factor synthesis and release of proteases, oxidants, and other molecules. Despite an increase in DNA synthesis, however, sublytic C5b-9 is associated with a delay in G2/M phase progression in podocytes. Here we induced sublytic C5b-9 injury in vitro by exposing cultured rat podocytes or differentiated postmitotic mouse podocytes to Ab and a complement source; we also studied the passive Heymann nephritis model of experimental membranous nephropathy in rats. A major finding was that sublytic C5b-9–induced injury caused an increase in DNA damage in podocytes both in vitro and in vivo. This was associated with an increase in protein levels for p53, the CDK inhibitor p21, growth-arrest DNA damage-45 (GADD45), and the checkpoint kinases-1 and -2. Sublytic C5b-9 increased extracellular signal-regulated kinase-1 and -2 (ERK-1 and -2), and inhibiting ERK-1 and -2 reduced the increase in p21 and GADD45 and augmented the DNA damage response to sublytic C5b-9–induced injury. These results show that sublytic C5b-9 induces DNA damage in vitro and in vivo and may explain why podocyte proliferation is limited following immune-mediated injury.
Pituitary Apoplexy
Authors: Robert Raskind
Journal: JAMA (1981)

<h3>To the Editor.—</h3> Regarding the article on pituitary apoplexy by Fitz-Patrick et al (1980;244:59), in the light of such excellent computed tomograms (CTs), I am wondering what the reason is for carrying out angiography and pneumoencephalography (PEG) in these cases. Carotid angiography was done to rule out a giant aneurysm in the days before CT scanning was available, but with high-resolution contrasted scans, I have considered this more or less pointless. With such a clear-cut history of endocrinopathy and enlargement and erosion of the sella turcica, I cannot figure out in any way how a spinal puncture contributes to the diagnosis and management. From the time the patient is seen in the emergency room, plain skull films, drawing of the endocrine panel, completion of the necessary preoperative lab work, and CTs can all be carried out within a space of four to six hours, and surgery can be carried out
Color Organ Scanner Refines Isotope Diagnostic Technique
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Development of Screening Tests for Aneuploidy Induction by Environmental Pollutants
Authors: Ilse-Dore Adler, James M. Parry
Journal: Environmental Health Perspectives (1993)

When legally required mutagenicity testing of chemicals is undertaken, the important genetic end point of aneuploidy is not included because validated test methods are lacking.Therefore, the Commission of the European Communities (CEC) has funded a research program to develop and validate tests for aneuploidy induction.Ten chemicals, selected on the basis of their ability to interact with cell organelles relevant for aneuploidy induction, were tested in 11 laboratories.The assays ranged from in vitro tubulin assembly studies to in vivo germ-cell tests.The results allow several conclusions: a) Fungal aneuploidy tests are not capable of detecting inhibitors of mammalian tubulin polymerization such as colchicine and vinblastine.Therefore, they will not play a role in screening for aneuploidy but are of value for studying the relationship between induced aneuploidy and recombination.b) Chemicals that induce aneuploidy in mammalian germ cells are readily detected in the in vitro mammalian cell systems.Some chemicals such as thiabendazole and thimerosal induce aneuploidy in vitro but do not appear to be very effective in vivo.c) Cell division aberrations induced in mammalian cells in vitro seem to be predictive for aneuploidy induction in the same cell type.Likewise, c-mitotic effects and cell cycle delay in vivo in mitotic and meiotic cells correlate with aneuploidy induction in the respective tissue.A second CEC Aneuploidy Program has started recently to refine the most promising test protocols, to provide understanding of the variety of mechanisms by which chemicals induce aneuploidy, and to establish a data base for aneugens among environmental pollutants.
Benefits and cost of computerized tomography in radiation therapy
Authors: M. U. Goitein
Journal: JAMA (1980)

The use of computerized tomography (CT) to guide the radiation therapy of cancer has been shown in several studies to have a major impact on the treatment process. The implications of these observations for the likely outcome of treatment provide two indications of the cost-effectiveness of CT in this application. First, the cost of CT relative to that of therapy is compared with the estimated increment in benefit due to CT relative to the benefit of therapy without CT. In this comparison, CT is found to be cost-effective by a factor of 5.5. Second, the cost of CT is compared with an estimate of the average increased cost of treatment when initial therapy has failed. This comparison favors CT by a factor of 4.6. These estimates are conservative and do not take into account possible reductions in morbidity for which CT may be responsible. (<i>JAMA</i>244:1347-1350, 1980)
Dr. Vallbona's Name Incorrect on Cover
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Construction of Contract to Cure Physician.
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction
Authors: Vinay Kamat
Journal: Annals of Internal Medicine (2002)

Ad Libitum15 January 2002CorrectionVinay Kamat, MDVinay Kamat, MDAlton, IL 62002Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-136-2-200201150-00027 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Yesterday, I droveflanked by lifeless buildings.The road sublimatedinto a pair of menwhose fates were sealedin reflective veststhat confessed:Department of Corrections.As one gatheredlitter, the otherinquiredthrough vacuouseyes:Given featuresso akin,where did our fatesjackknife?And I,built up speedto leavehis reflectiona few milesbehind. Author, Article, and Disclosure InformationAffiliations: Alton, IL 62002Corresponding Author: Vinay Kamat, MD, 2 Memorial Drive, Suite 220, Alton, IL 62002. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byA Rollercoaster Ride of Czech Credit Unions 15 January 2002Volume 136, Issue 2Page: 135KeywordsInterleukins ePublished: 15 January 2002 Issue Published: 15 January 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
The Thymic Wave Sign
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Capsule Endoscopy
Authors: M. Pennazio
Journal: Endoscopy (2005)

This year’s Digestive Disease Week saw the presentation of more than 80 studies focusing on capsule endoscopy (CE); this review discusses in detail the 20 most significant of these. Alongside various reports concerning technical aspects of the procedure, possible new applications have been studied, including in celiac disease. Obscure bleeding is now a consolidated indication to CE; however, prospective data on the impact of CE on clinical outcomes are still scarce. Opinions diverge on the effective role of CE in Crohn’s disease, and further research is needed to define this role. Research is also underway to develop capsules with propulsive and therapeutic capabilities. The strong interest in small-bowel endoscopy is also shown by the numerous studies concerning double-balloon enteroscopy, a complementary procedure to CE (Figure [1]).
Report of the Woman's Auxiliary
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
From the Food and Drug Administration
Authors: Stuart L. Nightingale
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
DOMESTIC CORRESPONDENCE.
Authors: Edward W. Jenks
Journal: JAMA (1885)

Detroit, Mich., December 15, 1884. To the Editor of the Journal of the American Medical Association: TheJournalof the 29th ult. contained a report of a case of " Unilocular Ovarian Cyst weighing ninety-five pounds, successfully removed by Dr. George E. Ranney, of Lansing, Michigan." In this report Dr. Ranney claims to have performed the operation, and generously gives Dr. Post, of Lansing, and myself, credit for valuable assistance which we rendered him. Inasmuch as the<i>Medical Age</i>, of this city, in its issue of October 25, contained a notice of this same case in which I was credited with having performed the operation, assisted by Dr. Ranney and others, the discrepancy has called forth sufficient comment to warrant, if not, indeed, to demand a statement from me. This statement I am constrained to make rather in the interest of truth and honesty than from a desire to enter into
Section 24.—Degenerative Joint Disease (Osteoarthritis)
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Chronic active hepatitis in hepatitis B surface antigen (HBsAg) carriers. The need for liver biopsy
Authors: R. Sampliner
Journal: JAMA (1977)

Four cases of chronic active hepatitis were found in hepatitis B surface antigen (HB<sub>s</sub>Ag) positive blood donors. Despite minimal symptoms, the full histologic spectrum of chronic hepatitis was seen. Because clinically occult liver disease can be histologically severe, liver biopsy is indicated when liver enzyme levels are persistently abnormal in long-term HB<sub>s</sub>Ag carriers. (<i>JAMA</i>237:50-51, 1977)
RETROPHARYNGEAL ABSCESS
Authors: CALVIN C. RUSH
Journal: JAMA (1918)

The subject of retropharyngeal abscess is so vaguely understood by many general practitioners, and the results of an error in diagnosis may be so disastrous, that the report of a case should be of value. The case is reported not on account of original material, but because of the lesson that it teaches. We are too prone to adopt the habit of looking for the usual condition in a part affected, and to overlook the unusual condition when it appears. The careless physician commits the sin of assuming the usual condition. In this case the baby's life could have been saved in hardly more time than a physician would consume in putting on his overcoat. One of two conclusions must be drawn, either a physician was not called or, having been called, was negligent. A digital examination would have given him the diagnosis. No history of the disease can be
&lt;emph&gt;Book Notices&lt;/emph&gt;
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
New Methods for Detection of Low Levels of DNA Damage in Human Populations
Authors: William A. Haseltine, William Franklin, Judith A. Lippke
Journal: Environmental Health Perspectives (1983)

The use of a postlabeling method to characterize and to detect infrequent base modifications in DNA is outlined. This method has the advantage that low levels of DNA modifications, approximately 1 modified base per 10(5) nucleotides, can be detected. Moreover, a broad spectrum of modification can be identified by using this methodology. The basis for the method involves transfer of a radioactive phosphate from the gamma position of ATP to the 5'-hydroxyl terminus of 3'-phosphoryl nucleotides that are derived from modified DNA by appropriate nuclease digestion. The second method involves use of a defined DNA sequence within human cells. The alpha sequence is used as a probe for DNA damage to specific nucleotides. The alpha DNA sequence is reiterated approximately 300,000 times in the human genome and exists in tandem arrays. It comprises approximately 1% of the entire genome. The reiterated sequence is sufficiently homogeneous to permit its use as a probe for a site specific in DNA damage. Examples of the application of both of these methodologies to DNA damage inflicted in human cells by chemicals and ultraviolet light are provided.
Sentence Added to Author Contributions
Journal: JAMA Internal Medicine (2017)

Drew B. Day, PhD; Jianbang Xiang, BS; Jinhan Mo, PhD; Feng Li, MD, PhD; Mingkei Chung, PhD; Jicheng Gong, PhD; Charles J. Weschler, PhD; Pamela A. Ohman-Strickland, PhD; Jan Sundell, MD; Wenguo Weng, PhD; Yinping Zhang, PhD; Junfeng (Jim) Zhang, PhD
A fragment of secreted Hsp90α carries properties that enable it to accelerate effectively both acute and diabetic wound healing in mice
Authors: Chieh-Fang Cheng, Divya Sahu, Fred Tsen, Zhengwei Zhao, Jianhua Fan, Rosie Kim, Xinyi Wang, Kathryn O’Brien, Yong Li, Yuting Kuang, Mei Chen, David T. Woodley, Wei Li
Journal: Journal of Clinical Investigation (2012)

In Figure 2, concentrations of the recombinant Hsp90α added to the real wounds in mice were inaccurate.The correct figure and legend appear below.