tbuckley/cabot-search huggingface dataset:
ROYAL FREE HOSPITAL: ULCER OF THE STOMACH (?), COMPLICATED WITH AMENORRHOEA, TREATED SUCCESSFULLY
Authors: W. Brinton
Journal: BMJ (1856)

was admitted an out-patient of the Royal Free Hospital on the 13th of November, 1855.As a child, her health had been good.She began to menstruate at the usual age, and continued to do so regularly almost up to the above date.The quantity of the flux had,however,gradually becomemore scanty during the last five or six months; though 't was only at the last menstrual period prior to her application at the Hospital that its decrease amounted to complete amenorrhea.About two years before the date of her admission she began to suffer from symptoms of severe indigestion :-espe- cially capricious (generally deficient) appetite; pain in the region of the stomach and between the shoulders, usually coming on about an hour after eating; and irregular (mostly sluggish) action of the bowels.After about twenty months of these symptoms, vomiting, which had previously
City Sunlight
Authors: M. Therese Southgate
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CHESS criteria for the screening of varices in patients with compensated advanced chronic liver disease: a multicenter study
Authors: Xiaolong Qi, Chuan Liu, Jia Li, Yan Wang, Huihong Huang, Xiaoling Chi, Yong Zhang, Li Yang, Chaohui He, Fangze Huang, Lili Zhao, Huanming Xiao, Lin Zhang, Wenjuan Wang, Liting Zhang, Xiaorong Mao, Dan Xu, Yifei Huang, Changqing Yang, Guo Zhang, Zicheng Jiang, Ye Gu, Fengmei Wang, Jiahong Dong
Journal: Journal of Hepatology (2020)
DROWNING ACCIDENTS.
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The complementary role of environmental and security biological control regimes in the 21st century
Authors: G. S. Pearson
Journal: JAMA (1997)

As we approach the 21st century, there is increased worldwide concern about disease, whether natural or deliberate, in humans, animals, and plants. There are 2 driving forces for multilateral biological control regimes: international/ national security and environmental protection. With respect to deliberately caused disease, these seemingly disparate forces are mutually reinforcing as demonstrated by simultaneous moves to strengthen the Biological and Toxin Weapons Convention and the entry into force of the Convention on Biological Diversity. Future multilateral biological control regimes based on these developments will aid the security, prosperity, and health of the world community.
How Much Rituximab Do We Need: A Multicenter, Randomized Trial Comparing 1, 3 or 6 Infusions of Rituximab Added to 6 Cycles of CHOP Chemotherapy in Untreated Patients with Advanced Follicular Non-Hodgkins Lymphoma (HD2000-Trial).
Authors: Manfred Hensel, Lars Scheuer, Hans Salwender, Juergen Finke, Dieter Buerkle, Heinz Albert Duerk, Andreas Kaebisch, Ralf Naumann, Hans-Juergen Staiger, Ingo Schmidt-Wolf, Martin Kornacker, Eugen Leo, Joseph Fischer, Anthony D. Ho
Journal: Blood (2004)
Adverse Events and Quadrivalent Human Papillomavirus Recombinant Vaccine—Reply
Authors: John Iskander
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lung Dysfunction and Chronic Liver Disease
Authors: Carl A. Brodkin
Journal: Annals of Internal Medicine (1996)

Letters1 February 1996Lung Dysfunction and Chronic Liver DiseaseCarl A. Brodkin, MD, MPHCarl A. Brodkin, MD, MPHUniversity of Washington; Seattle, WA 98104Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-124-3-199602010-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In their review article on the hepatopulmonary syndrome, Lange and Stoller [1] provide an excellent discussion of possible pathogenic mechanisms and therapeutic options for intrapulmonary vascular dilatations associated with chronic liver disease. The authors' description of spring-coil embolization therapy as “disappointing” may, however, be overly pessimistic. As reported by the authors, the patient described by me [2] and by Felt and colleagues [3] had moderate improvement in room air Pao2, from 38 mm Hg before embolization to 53 mm Hg after embolization. It must be emphasized that this change in oxygenation was accompanied by substantial improvement in ...References1. Lange PA, Stoller JK. The hepatopulmonary syndrome. Ann Intern Med. 1995; 122:521-9. Google Scholar2. Brodkin CA. Multiple pulmonary arteriovenous fistulas in a cirrhotic female: a case of pulmonary spider nevi. American College of Physicians 67th Annual Session, San Francisco, April 1986:24. Google Scholar3. Felt RW, Kozak BE, Rosch J, Duell BP, Barker AF. Hepatogenic pulmonary angiodysplasia treated with coil-spring embolization. Chest. 1987; 91:920-2. Google Scholar4. Hatfield DR, Fried AM. Therapeutic embolization of diffuse pulmonary arteriovenous malformation. AJR Am J Roentgenol. 1981; 137:861-3. Google Scholar5. Terry PB, Klemens BH, Kaufman SL, White RI. Balloon embolization for treatment of pulmonary arteriovenous fistulas. N Engl J Med. 1980; 302:1189-90. Google Scholar Author, Article, and Disclosure InformationAuthors: Carl A. Brodkin, MD, MPHAffiliations: University of Washington; Seattle, WA 98104 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1996Volume 124, Issue 3Page: 369KeywordsChronic liver diseaseDyspneaExerciseLungsOxygenPathogens ePublished: 15 August 2000 Issue Published: 1 February 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Gene mappers form collaborations
Authors: C. Marwick
Journal: JAMA (1988)

NEW ALLIANCES are forming to address one of this century's greatest scientific challenges—mapping and sequencing the human genome. In recent months, organizations with an interest in tackling the problem have decided to collaborate in deciding how the ambitious project will be managed nationally and internationally. The National Institutes of Health (NIH) and the Department of Energy (DOE), the two agencies that were considered major rivals for leadership of the US program, reached a rapprochement of sorts in September. That month, the NIH director, James B. Wyngaarden, MD, and Robert O. Hunter, PhD, director of the DOE's Office of Energy Research, drafted a memorandum of understanding establishing a joint scientific advisory commission and interagency working group, both consisting of representatives from the two agencies. The memorandum had the two agencies agreeing to sponsor an annual symposium to evaluate progress, to share information, and to cooperate in awarding research grants. They also
mIR-21 is increased in patients with NASH-associated HCC and contributes to hepatocarcinogenesis in mice with NAFLD
Authors: Pedro Miguel Rodrigues, Marta B. Afonso, André Simão, Tawhidul Islam, Maria Manuela Gaspar, Colm O Rourke, Jesper Andersen, Alvaro Santos-Laso, Raul Jimenez-Aguero, Emma Eizaguirre, Luis Bujanda, María Jesús Pareja, Carina Prip-Buus, Jesus M. Banales, Cecília M.P. Rodrigues, Rui E. Castro
Journal: Journal of Hepatology (2020)
Diabetes
Authors: Elliott P. Joslin, Leo P. Krall, C. C. Bailey, Howard F. Root, Priscilla White, Alexander Marble
Journal: New England Journal of Medicine (1948)

Metabolic Changes Clinical reports as well as chemical studies emphasize certain new features in diabetic acidosis. The case report of Holler13 showed that it is possible for a patient in diabetic acidosis to develop a critically low level of potassium in the blood serum, with paralysis of respiration that may be relieved by the administration of a potassium-containing solution.Martin and Wertman14 have analyzed serial measurements of the serum potassium, magnesium and calcium concentrations in 14 patients with diabetic acidosis (carbon dioxide combining power below 9 milliequiv. per liter). Three patients were comatose on admission, 3 were semicomatose, and 8 . . .
Abstract 3107: Arm Exercise Stress Testing Variables Predict Survival and Adverse Clinical Outcomes
Authors: Nasreen Ilias, Xian Hong, Cindi Inman, Wade Martin
Journal: Circulation (2007)

Valuable prognostic and clinical information from treadmill exercise testing (GXT) includes exercise capacity (METs), heart rate, and electrocardiographic (ECG) responses. However, little or no prognostic data are available for arm ergometer stress testing (AXT). To determine whether AXT variables predict survival, myocardial infarction (MI), or coronary revascularization (CVASC), we performed AXT from 1997 to 2002 in 359 patients, mean age 63 +/− 11 (SD) years, referred for clinical reasons but unable to perform GXT, and followed for 63 +/− 24 months, during which 98 deaths occurred (27%). Average annual mortality, MI, CVASC, and combined adverse event rates were 5.2%, 1.7%, 2.2%, and 7.1%, respectively. Student’s t-tests were used to assess differences between outcome groups. Cox regression models were employed to determine hazard ratios (HR) and 95% confidence intervals (CI). Kaplan-Meier survival models were used to compare survival curves among AXT groups. AXT METs was highly predictive of survival after adjustment for age and beta blocker treatment (p &lt; 0.001; when stratified by tertiles; death HR 0.47, CI 0.22– 0.71 middle vs. lowest; HR 0.61, CI 0.28 – 0.94 highest vs. middle). A greater delta (peak-rest) heart rate was associated with survival (p = 0.0003) and/or event-free outcome as were faster % age-predicted peak heart rate (death HR 0.58, CI 0.36 – 0.80 for &gt;70% vs.&gt; 70%), higher exercise systolic blood pressure (SBP) (p = 0.002) and peak heart rate x SBP product (PRPP) (p = 0.0006). A positive (+) AXT ECG was observed in 22% of deaths and 10% of survivors, 27% of MI and 12% with no MI, and 32% of CVASC versus 11% with no CVASC. A+AXT ECG was a powerful predictor of adverse outcome, even after accounting for peak heart rate, peak SBP and PRPP (death HR 2.2, CI 1.94 –2.43; MI HR 2.9, CI 2.48 –3.30; CVASC HR 4.1, CI 3.73– 4.43; combined events HR 2.8, CI 2.55–2.98). Sensitivity, specificity, positive and negative predictive values of a +AXT ECG in prognosticating adverse outcomes ranged from 22–31%, 88 –92%, 18 – 61%, and 62–92%, respectively. Thus, in veterans who are older and have more comorbidities than most other study populations based on adverse event rates, AXT is an alternative to GXT for predicting clinical outcome in patients with lower extremity disabilities.
CAN ACQUIRED IMMUNITY BE TRANSMITTED BY HEREDITY?
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A new marker for severe drug reactions in the skin ‐ interferon‐γ‐induced protein 10
Journal: British Journal of Dermatology (2020)

Stevens‐Johnson syndrome/toxic epidermal necrolysis and drug reaction with eosinophilia and systemic symptoms (DRESS) are all serious and potentially life‐threatening reactions to medicines, which differ from each other both in appearance and by the way in which the skin signs and symptoms associated with each develop.
Leadership Program Awards to Residents and Fellows
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The medical school of a land-grant university and its relation to the health care of the state. Medical manpower--a continuing crisis
Authors: V. E. Wilson
Journal: JAMA (1967)

For more than a century the federal government and the land-grant educational institutions have shared a partnership which demonstrated cooperative endeavor without mutual interference. Continuing objectives of the partnership have been the development and rapid application of new knowledge in agriculture and engineering for the direct benefit of the public. From this relationship have come dramatic changes in the pattern of rural life and the creation of the most productive agricultural system in the world. The system established by land-grant colleges and universities is most interesting when compared with present day health problems and proposed solutions. The first of the enabling legislation for these schools was passed in 1862. It represented an attempt to equalize opportunities in education and in employment. However, mitigation of an obvious economic need was not the sole aim of the architects of the Morrill Act. They were prompted, also, by an acute awareness of widespread
Diagnostic Oncology
Authors: Peter W. Nichols
Journal: JAMA (1992)

This attractive, glossy publication from Karger claims to be the only journal that pulls together in one place articles on cancer diagnosis. It will cover "pathology and cytology, imaging, endoscopy, biochemistry and immunodiagnosis." Subject matter in the first issues reflects this policy. All manuscripts are subject to editorial review. An editorial board of 16 includes four Americans and four Canadians. Each of the first three issues contains at least nine articles in 60 to 70 pages. Articles are identified as editorials, reviews, and case reports. In addition, each issue publishes several articles grouped together in a separately edited symposium. Two issues also contained a curious section on "Travel and Leisure": one had a recipe for chocolate cake and the other discussed Texas wine and European cultural festivals. The first page of each article gives a complete bibliographic citation, first author's affiliation, suggested key words, and a brief abstract. Abstracts are
Abstract 788: Identification and optimization of pro-apoptotic molecules targeting adenine nucleotide translocator 2 (hANT2) in tumor mitochondria
Authors: Nelly Buron, Claire Pertuiset, Roxane Loyant, Cécile Martel, Mathieu Porceddu, Annie Borgne-Sanchez
Journal: Cancer Research (2019)

Abstract The mitochondrial protein ANT2 is one of the four isoforms of the ADP/ATP translocase and is expressed in highly proliferating cells. ANT2 plays a crucial role in the maintenance of transmembrane potential and mitochondrial integrity in tumor cells by importing glycolytic ATP into the mitochondrial matrix. Thus, this protein is required for tumor cell survival and displays anti-apoptotic function. Recently, ANT2 upregulation was shown to be involved in drug resistance process in various cancer types. Considering ANT2 role in tumor cell metabolism, we searched for ANT2-ligand small molecules. Ligands were first identified by virtual screening of chemical library on 3D model of human ANT2 and validated as ADP/ATP translocase inhibitors using our screening platform on isolated mitochondria. Compound specificity for ANT2 isoform was validated by cellular knock-down and pull-down experiments. ANT2-ligands optimization lead to the selection of MTL105 compound that induce characteristic intrinsic apoptotic cell death, specifically in tumor cell lines at sub-µM concentrations with no effect on healthy cells, suggesting a strong safety margin. According to the NCI60 compare analysis, this compound constitutes a first-in-class product in cancer therapy with this MoA and would be particularly interesting to overcome multidrug-resistant cancers. Citation Format: Nelly Buron, Claire Pertuiset, Roxane Loyant, Cécile Martel, Mathieu Porceddu, Annie Borgne-Sanchez. Identification and optimization of pro-apoptotic molecules targeting adenine nucleotide translocator 2 (hANT2) in tumor mitochondria [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 788.
The nation's changing blood supply system
Authors: J. McCullough
Journal: JAMA (1993)

DURING the past several years, great interest has developed in the safety of the blood supply in the United States and the manner in which our nation's blood supply is obtained and distributed. Today, this country's blood bank system finds itself in a changed regulatory environment; under considerable public scrutiny; carrying out a much larger, more complex work load; in a more litigious environment; with an organizational infrastructure in need of strengthening at a time of increasing cost constraints; and viewed by some as having inadequately responded to the issues of the 1980s. The manner and effectiveness with which the present issues in blood banking are resolved will have a major impact on the system used to obtain the nation's blood supply and the safety, adequacy, and cost of that supply. This article examines the present issues of concern in the US blood banking system and describes how the outcome
Sulfamethoxazole-trimethoprim-resistant pneumococcal sepsis
Authors: M. Markman
Journal: JAMA (1982)

THE SUCCESS of bone marrow transplantation in the treatment of aplastic anemia and acute leukemia has resulted in an increasingly large number of long-term survivors of this procedure. The occurrence of infections in these patients has been recognized as a major cause of morbidity and mortality, particularly in those patients in whom chronic graft-v-host disease develops.<sup>1</sup><i>Streptococcus pneumoniae</i>has been noted to cause a substantial portion of the reported infections,<sup>1,2</sup>and it has been suggested that immunization with polyvalent pneumococcal vaccine and long-term antibiotic prophylaxis be used to prevent this complication.<sup>2</sup> Reports of pneumococci both resistant to penicillin in vitro and producing clinically important infection have been a cause of great concern.<sup>3</sup>While some of these organisms have been found to be resistant to sulfamethoxazole-trimethoprim as well as penicillin,<sup>3</sup>there have been, to our knowledge, no reports of penicillin-sensitive/sulfamethoxazole-trimethoprim-resistant pneumococci causing clinical infection. We report