tbuckley/cabot-search huggingface dataset:
Cigarette smoking and invasive cervical cancer
Authors: L. A. Brinton
Journal: JAMA (1986)

A case-control study of 480 patients with invasive cervical cancer and 797 population controls, conducted in five geographic areas in the United States, included an evaluation of the relationship of several cigarette smoking variables to cervical cancer risk. Although smoking was correlated with both age at first intercourse and number of sexual partners, a significant smoking-related risk persisted for squamous cell carcinoma after adjustment for these factors (relative risk, 1.5). The risk of squamous cell cancers increased significantly with intensity and duration of smoking. Twofold excess risks were seen for those smoking 40 or more cigarettes per day and those smoking for 40 or more years. In addition, users of nonfilter cigarettes were at particularly high risk. Increased risks, however, were observed only among recent and continuous smokers. In contrast to squamous cell cancer, no relationship was observed between smoking and risk of adenocarcinoma or adenosquamous carcinoma (n=63). These results suggest a causal relationship between cigarette smoking and invasive squamous cell cervical cancer, perhaps through a late-stage or promotional event, although the mechanisms of action require further elucidation. (<i>JAMA</i>1986;255:3265-3269)
Serogroup C meningococcal outbreaks in the United States. An emerging threat
Authors: L. A. Jackson
Journal: JAMA (1995)

<h3>Objective.</h3> —Multiple outbreaks of serogroup C<i>Neisseria meningitidis</i>have recently been reported from diverse areas of the United States. To better define the characteristics of this increasingly important problem, we reviewed data on all known serogroup C outbreaks in the United States from January 1980 through June 1993. <h3>Data Sources.</h3> —MEDLINE searches, Centers for Disease Control and Prevention records, state health department officials, infectious disease experts, and the meningococcal vaccine manufacturer. <h3>Definition of an Outbreak.</h3> —Three or more cases of serogroup C meningococcal disease within a 3-month period, either among members of a community or persons attending a single school or other institution, for which those cases represented an attack rate of at least five per 100 000 population. <h3>Results.</h3> —Twenty-one outbreaks of serogroup C meningococcal disease were identified; eight occurred since 1991. In 1992 and the first half of 1993, approximately 180 000 doses of vaccine were administered for outbreak control, compared with approximately 34000 doses from 1980 to 1991. Approximately 50% of community-outbreak cases were between the ages of 5 and 24 years, compared with only 19% of sporadic serogroup C cases (<i>P</i>&lt;.001). Subtyping of patient isolates indicates that outbreaks are clonal; however, at least five distinct but closely related strains have caused recent outbreaks. <h3>Conclusions.</h3> —Serogroup C outbreaks are occurring more frequently in the United States. The effectiveness of preventive measures depends on early recognition; therefore, physicians should promptly report all cases of suspected meningococcal disease, and the causative serogroup should be established for every case. (<i>JAMA</i>. 1995;273:383-389)
Toxicology and Applied Pharmacology, New York
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Selected Abstracts
Journal: JAMA (1974)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
WHO SHOULD TREAT CANCER?
Authors: J.S Tobias, M.J Peckham, P.G Harper, M.H.N Tattersall, J.M.A Whitehouse, C.J Williams, H Macdonald, R.H Ryle, P.E Bodkin, R Buchanan, V Hall, J.S Malpas, P.S.M Wrigley, T.A Lister, T.J Mcelwain, J.F Smythe, K.C Calman, T Habeshaw, D Crowther
Journal: The Lancet (1981)
Emotion theory?
Authors: Nico H. Frijda
Journal: Behavioral and Brain Sciences (2000)

The book contains a masterly review of Rolls's single-neuron research reflecting rewards. It places that research in the context of the neo-behaviorist theory of emotions. That theory provides a useful first approximation to emotion-eliciting conditions but has little to tell about emotions as motivational states or response dispositions: nor does it give a rationale for what are considered to be primary rewarding stimuli.
Appointment to Norman, Okla., Institution.
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Penicillin-Gentamicin
Authors: Donald Kaye
Journal: JAMA (1973)

<h3>To the Editor.—</h3> Weinstein and Moellering<sup>1</sup>recommend penicillin in combination with gentamicin instead ofstreptomycin for therapy of enterococcal endocarditis. This recommendation is based in part on our series<sup>2</sup>that reported a 17% mortality rate in patients with enterococcal endocarditis treated with penicillin in combination with streptomycin. Weinstein and Moellering attributed our failures to inadequate antibiotic response. However, we clearly stated that none of the failures was related to failure of antibiotic therapy but to congestive heart failure, emboli, ruptured aneurysm, myocardial infarction, vasculitis, and even metastatic carcinoma occurring<i>during therapy</i>, often early in therapy. These complications (excluding carcinoma) are well known to occur in spite of control of infection. In fact, our results with enterococcal endocarditis treated with penicillin and streptomycin compare favorably with our results in nonenterococcal streptococcal endocarditis.<sup>3</sup>The favorable results in our report and subsequent experience with enterococcal endocarditis is excellent evidence for recommending
Pituitary Function Following Treatment with Reproductive Toxins
Authors: Ralph L. Cooper, Jerome M. Goldman, Georgia L. Rehnberg
Journal: Environmental Health Perspectives (1986)

Appropriate regulation of reproductive processes are dependent upon the integrity of pituitary function. In this selected review, we evaluate the evidence that certain environmental compounds exert their effect on reproductive function via a direct action on the pituitary gland. We also discuss examples of changes in pituitary hormone secretion that occur in response to changes in neuronal or gonadal control of the pituitary. A limited number of studies suggest that measures of pituitary hormone secretion provide an early and sensitive measure of a compound's potential effects on the reproductive system. However, the most striking aspect of this area is the sparse and inconsistent information describing pituitary function following exposure to environmental pollutants.
Optical coherence tomography of basal cell carcinoma: influence of location, subtype, observer variability and image quality on diagnostic performance
Authors: J. Holmes, T. von Braunmühl, C. Berking, E. Sattler, M. Ulrich, U. Reinhold, H. Kurzen, T. Dirschka, C. Kellner, S. Schuh, J. Welzel
Journal: British Journal of Dermatology (2018)

Nonmelanoma skin cancer (NMSC) is the most common cancer affecting white‐skinned people worldwide, outnumbering all other cancers combined. Basal cell carcinoma (BCC) is the most common NMSC, with at least 100 000 new cases diagnosed in the UK each year, rising 4–10% every year, placing an ever‐increasing burden on healthcare services. At least 50% of skin biopsies for BCC are negative (no cancer tumour present) and so dermatologists wish for a non‐invasive imaging tool (i.e. using an image rather than biopsy surgery) that could provide more information to make a diagnosis to avoid unnecessary biopsies. This study of 256 BCC patients was performed at 6 centres based in Germany. The study examined the accuracy of diagnosis of BCC using a novel imaging device, the VivoSight Optical Coherence Tomography (OCT) scanner. A 2015 publication from this study (Ulrich et al., Brit. J. Dermatology, (15), 173, pp 428–435) reported that the accuracy of diagnosis using OCT was much improved over clinical/dermoscopic examination, in which a doctor examines the skin just by sight or using a handheld magnifier called a dermatoscope. In the present paper, the authors report on further analysis of the data: diagnostic performance – meaning the accuracy of the diagnosis – did not depend on where the lesion (affected patch of skin) was located on the body; that diagnostic performance was reduced when the lesion had scales/crusting (but was still superior to clinical/dermoscopic examination); that diagnostic performance was consistent between different medics (meaning their diagnoses were largely the same) and that they were more likely to be correct when they had high confidence in their diagnosis; and that BCC subtype can be diagnosed from OCT with moderate accuracy (62–72%). These conclusions support the targeted use of OCT to aid the diagnosis of BCC, potentially improving the standard of care by enabling more early‐stage BCCs to be detected and by supporting the use of non‐invasive treatment options.
Abstract 41: Evidence Against Mycoplasma pneumonia as An Etiologic Agent of Kawasaki Disease
Authors: Samuel R Dominguez, Marsha S Anderson, Heather R Heizer, Pei-Ni Jone, Christine C Robinson, Mary P Glodé
Journal: Circulation (2015)

Background: The etiology of Kawasaki Disease (KD) remains unknown. The majority of KD patients present with a history of, or concurrent respiratory symptoms. Isolated case reports of Mycoplasma pneumoniae (Mp) associated with KD have been reported. Since Mp can cause mucous membrane disease (eye and mouth lesions), rash, and fevers, it remains a possible etiological agent for KD. Objective: To evaluate the prevalence of Mp identified in the upper respiratory tract of patients admitted with a diagnosis of KD. Methods: All KD patients admitted to Children’s Hospital Colorado (CHCO) over a 14 month period (Feb 2013 - Mar 2014) who had a nasopharyngeal wash (NPW) submitted for diagnostic testing were included in the study. Mp PCR was performed using the Film Array Respiratory Panel (BioFire Diagnostics, Salt Lake, City, UT). Furthermore, a CDC investigated pediatric outbreak of Mp in our community afforded the opportunity to investigate an epidemiological association between Mp and KD by comparing the incidence of KD to the incidence of Mp positive respiratory samples from Jan 2013 - May 2014. Results: Forty-seven (65%) of 72 KD patients had a NPW submitted and tested for Mp. None of these 47 patients tested positive for Mp. During 2013 - 2014 there was no correlation between the overall incidence of Mp positive respiratory samples and the incidence of KD. Conclusions: Our data do not support the hypothesis that Mp is an etiological agent of KD. Although unlikely, this study does not exclude the possibility that another Mycoplasma species could be involved in the pathogenesis of KD.
Lehrbuch der inneren Medizin. Band III: Innere Sekretion, Stoffwechsel, Niere, Muskeln, Gelenke, Knochen, Infektionen, Intoxikationen
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Stomach Cancer
Authors: Janet M. Torpy
Journal: JAMA (2004)

Stomach CancerI n the United States, more than 20,000 individuals are diagnosed with gastric (stomach) cancer each year.Men are more likely to have stomach cancer than women are.Stomach cancer usually affects persons who are older than 55 years, although it may occur at younger ages.Individuals from Asia have the highest rates of stomach cancer.Because stomach cancer may occur without symptoms, it may be in advanced stages by the time the diagnosis is made.Treatment is then directed at making the patient more comfortable and improving quality of life.Stomach cancer can metastasize (spread) to other organs of the body.The January 14, 2004, issue of JAMA includes an article about gastric cancer.
Lactoferrin: Molecular Structure and Biological Function
Authors: B. Lonnerdal
Journal: Annual Review of Nutrition (1995)

Lactoferrin is an 80-kDa, iron-binding glycoprotein present in milk and, to a lesser extent, in exocrine fluids such as bile and tears. It consists of a single-chain polypeptide with two gobular lobes and is relatively resistant to proteolysis. The complete cDNAs for lactoferrin from human milk, neutrophils, and bovine milk have been reported, and recombinant proteins have been produced. Owing to its iron-binding properties, lactoferrin has been proposed to play a role in iron uptake by the intestinal mucosa and to act as a bacteriostatic agent by withholding iron from iron-requiring bacteria. Its presence in neutrophils and its release during inflammation suggest that lactoferrin is also involved in phagocytic killing and immune responses. Additionally, lactoferrin may function in ways not related to iron-binding, e.g. as a growth factor and as a bactericidal agent. This review attempts to evaluate these proposed functions and their biological significance in more detail.
3. Oral Cephalosporins
Journal: JAMA (1977)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
使用智能手机和深度学习技术来帮助诊断皮肤癌
Authors: Y.Q. Jiang, J.H. Xiong, H.Y. Li, X.H. Yang, W.T. Yu, M. Gao, X. Zhao, Y.P. Ma, W. Zhang, Y.F. Guan, H. Gu, J.F. Sun
Journal: British Journal of Dermatology (2020)

基底细胞癌 (BCC) 是最常见的皮肤癌,发病率迅速上升。BCC 的诊断需要仔细检查皮肤的显微镜下图像,由于需要分析的图像很多,因此是一项劳动密集型的工作。 已开发出计算机辅助性疾病诊断方法,以帮助分析病理学中的显微镜下图像(即通过检查已切除的组织来研究和诊断疾病)。尤其是深度学习方法(即机器“学习”执行任务的一种方法)能够识别和捕获图像中的模式,并且在病理学图像相关任务上表现出显著改善的性能。 在这项来自中国的研究中,作者旨在开发基于智能手机捕获的显微镜目镜图像 (MOI) 而非全切片图像 (WSI) 的 BCC 自动识别的深度学习框架。使用智能手机摄像机从显微镜目镜拍摄 MOI。共收集了 8046 个 MOI 和 128 个 WSI,用于构建模型。 开发了两种识别 BCC 的深度学习框架,具有高灵敏度和特异度(指准确度)。与接受 WSI 培训的模型相比,通过智能手机识别 BCC 可被视为未来的临床选择。 本摘要涉及研究: 通过深度神经网络识别智能手机捕获的数字组织病理学图像上的基底细胞癌
Dairy intake and the insulin resistance syndrome in the CARDIA Study.
Authors: Mark A Pereira, David R Jacobs, Joan E Hilner, Linda Van Horn, Martha L Slattery, David S Ludwig
Journal: Circulation (2001)

P71 Little is known about the potential role of dairy consumption in the etiology of cardiovascular disease. We studied associations between reported dairy intake and components of the insulin resistance syndrome in a prospective study of young black and white adults. Participants attended up to five clinic examinations over a 10-year period beginning in 1985/6 (age = 18 to 35 years). The baseline and year-7 exam included a comprehensive diet history interview. Dependent variables include body mass index (BMI), waist-hip ratio (WHR), systolic blood pressure (SBP), and concentrations of fasting serum insulin, plasma triacylglycerol (Trg), and plasma HDL-cholesterol. Final sample size was 2929 after attrition and exclusions for diabetes, medication use, and pregnancy. Year 10 means of these variables were compared across quintiles of total dairy food and beverage intake with adjustment for their baseline values and for age, physical activity, smoking, education, race, sex, and intake of energy, alcohol, saturated fat, dietary fiber, and vitamin supplements. Dairy intake was associated with all components of the insulin resistance syndrome in a protective manner as follows: BMI: quintile 5 (&gt; 28.4 times/wk) - quintile 1 (&lt; 9.5 times/wk) = -0.5 kg/m2, p for linear trend across quintiles = .003; WHR: -0.01, p =.02; SBP: -1.9 mmHg, p=.02; insulin: -0.6 μU/ml, p = .02; Trg: -4.3 mg/dl, p = .04; HDL:+0.9 mg/dl, p = .12. Studies are needed to determine the mechanisms through which dairy intake may modify risk factors for cardiovascular disease.
The Practical Care and Feeding of Children.
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Circulating immune-profile as predictor of outcome in NSCLC patients treated with nivolumab
Authors: M. Tiseo, M. Veneziani, F. Gelsomino, F. Facchinetti, P. Bordi, E. Rapacchi, A. Squadrilli, S. Buti, G. Missale, A. Ardizzoni
Journal: Annals of Oncology (2017)
Ohio State Sanitary Association.
Journal: JAMA (1883)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal