Models in the Development of Clinical Practice Guidelines
Authors: J. Dik F. Habbema, Timothy J. Wilt, Ruth Etzioni
Journal: Annals of Internal Medicine (2015)

Letters7 April 2015Models in the Development of Clinical Practice GuidelinesJ. Dik F. Habbema, PhD, Timothy J. Wilt, MD, MPH, and Ruth Etzioni, PhDJ. Dik F. Habbema, PhDFrom Erasmus MC University Medical Center, Rotterdam, the Netherlands; University of Minnesota School of Medicine, Minneapolis, Minnesota; and Fred Hutchinson Cancer Research Center, Seattle, Washington.Search for more papers by this author, Timothy J. Wilt, MD, MPHFrom Erasmus MC University Medical Center, Rotterdam, the Netherlands; University of Minnesota School of Medicine, Minneapolis, Minnesota; and Fred Hutchinson Cancer Research Center, Seattle, Washington.Search for more papers by this author, and Ruth Etzioni, PhDFrom Erasmus MC University Medical Center, Rotterdam, the Netherlands; University of Minnesota School of Medicine, Minneapolis, Minnesota; and Fred Hutchinson Cancer Research Center, Seattle, Washington.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L15-5075-2 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We welcome Dr. Zacharioudakis and colleagues' comment about the effect of internal validity on model quality and the corresponding guideline. Internal validity, or calibration, refers to successful fitting of the model to the results of primary studies (1). Models with high internal validity are necessary to reliably inform guideline developers. Zacharioudakis and colleagues' statements reaffirm our remark that consensus standards for model quality have not been established.We believe that their suggestion that models should be calibrated to “every meaningful measurement that is published” is not realistic. Given the enormous amount of published meaningful measurements, judgments on data ...References1. Kopec JA, Finès P, Manuel DG, Buckeridge DL, Flanagan WM, Oderkirk J, et al. Validation of population-based disease simulation models: a review of concepts and methods. BMC Public Health. 2010;10:710. [PMID: 21087466] doi:10.1186/1471-2458-10-710 CrossrefMedlineGoogle Scholar2. Wever EM, Draisma G, Heijnsdijk EA, Roobol MJ, Boer R, Otto SJ, et al. Prostate-specific antigen screening in the United States vs in the European Randomized Study of Screening for Prostate Cancer-Rotterdam. J Natl Cancer Inst. 2010;102:352-5. [PMID: 20142584] doi:10.1093/jnci/djp533 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Erasmus MC University Medical Center, Rotterdam, the Netherlands; University of Minnesota School of Medicine, Minneapolis, Minnesota; and Fred Hutchinson Cancer Research Center, Seattle, Washington.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M14-0845. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoModels in the Development of Clinical Practice Guidelines J. Dik F. Habbema , Timothy J. Wilt , Ruth Etzioni , Heidi D. Nelson , Clyde B. Schechter , William F. Lawrence , Joy Melnikow , Karen M. Kuntz , Douglas K. Owens , and Eric J. Feuer Models in the Development of Clinical Practice Guidelines J. Dik F. Habbema , Timothy J. Wilt , Ruth Etzioni , Heidi D. Nelson , Clyde B. Schechter , William F. Lawrence , Joy Melnikow , Karen M. Kuntz , Douglas K. Owens , and Eric J. Feuer Models in the Development of Clinical Practice Guidelines Ioannis M. Zacharioudakis , Fainareti N. Zervou , and Eleftherios Mylonakis Models in the Development of Clinical Practice Guidelines Ioannis M. Zacharioudakis , Fainareti N. Zervou , and Eleftherios Mylonakis Metrics 7 April 2015Volume 162, Issue 7Page: 530-531KeywordsColorectal cancerDisclosureObservational studiesScreening guidelinesTreatment guidelines ePublished: 7 April 2015 Issue Published: 7 April 2015 CopyrightCopyright © 2015 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...