tbuckley/cabot-search huggingface dataset:
Prognosis After First Myocardial Infarction
Authors: Clifford J. Berger
Journal: JAMA (1992)

<h3>Objective.</h3> —To compare the short- and long-term prognosis following a first Q-wave or non-Q-wave myocardial infarction. <h3>Design.</h3> —Cohort study with a mean follow-up period of 5.1 ±4.9 years. <h3>Setting.</h3> —Population-based. <h3>Participants.</h3> —Framingham (Mass) Heart Study subjects with an initial recognized myocardial infarction during a 17-year period were studied, including 227 men and 136 women with a mean age of 67.2 years. Seventy-seven percent of first infarctions were Q-wave infarctions and 23% were non—Q-wave infarctions. <h3>Main Outcome Measures.</h3> —Reinfarction and death from coronary heart disease. <h3>Results.</h3> —During the follow-up period, subjects with non—Q-wave infarctions had a significantly higher rate of reinfarction than subjects in the Q-wave group (<i>P</i>=.02 for the entire follow-up). The 10-year reinfarction rates were 44.8% vs 27.4%. When analyzed separately by age and sex, differences in reinfarction rates were only noted in men and in those under the age of 65 years. There were no differences in coronary heart disease death rates based on Q-wave status, even when examined separately by age and sex. Multivariate analysis revealed a 1.8-fold higher risk of reinfarction in the non—Q-wave group (95% confidence interval, 1.1 to 3.1), and also demonstrated that baseline hypertension was an independent risk factor for predicting reinfarction (relative risk, 1.8; 95% confidence interval, 1.1 to 3.2). There were no differences in the rates of sudden death or all-cause mortality following the two types of myocardial infarction. Additionally, subjects with a first Q-wave infarction had a higher rate of subsequent congestive heart failure, while those with non—Q-wave infarctions had a significantly higher rate of coronary insufficiency (unstable angina with transient ST-T wave abnormalities). <h3>Conclusions.</h3> —These results confirm and extend findings from prior studies that have identified patients with first non—Q-wave myocardial infarctions as potentially unstable, with greater subsequent morbidity and similar mortality to their counterparts with Q-wave infarctions. (<i>JAMA</i>. 1992;268:1545-1551)
Highlighting Cancer Chemotherapy Reports
Journal: CA A Cancer Journal for Clinicians (1975)

on Prostatic Cancer held in June 1973 at Roswell Park Memorial Institute in Buffalo, New York.This workshop dealt with a broad range of topics con cerning prostatic cancer and should be a valuable reference source for years to come.The meeting was organized into three sessions: Etiology and Prevention, Detection and Diag nosis, and Treatment.In each session six to nine full papers as well as three to four discussion papers were presented.A general discussion followed each session.The following topics were covered in the etiology and pre vention session: Characterization of prostatic cancer among blacks (M .A. Jackson et al., Howard University, Washing ton, D.C.);
Adolescents' perceptions of factors affecting their decisions to seek health care
Authors: K. R. Ginsburg
Journal: JAMA (1995)

<h3>Objective.</h3> —To have adolescents, rather than adults, identify characteristics of health care providers and sites that affect their decision to seek care. <h3>Design.</h3> —Five stages conducted over a 10-month period: (1) focus groups to frame the study questions; (2) nominal group technique to generate student responses; (3) three surveys to assess response importance; (4) one survey to link the most important responses with the decision to seek care; and (5) focus groups to explain the variables associated with the decision to seek care. <h3>Setting.</h3> —The Philadelphia (Pa) School District. <h3>Participants.</h3> —The study population consisted of all ninth graders from 39 of Philadelphia's 42 public high schools. The 6821 students who returned the final survey comprised the study sample (69% of in-school youth). <h3>Results.</h3> —In the final survey, students used a Likert scale (1 to 5) to describe the impact of 31 ideas on their decision to seek care. The most important characteristics were provider hand washing, clean instruments, honesty, respect toward teens, cleanliness, know-how, carefulness, experience, seronegativity for the human immunodeficiency virus, equal treatment of all patients, and confidentiality. There was little variation in the order of the items by sex, race, or socioeconomic status. Factor analysis showed that the most important of four identified latent factors related to infection control and provider competency. <h3>Conclusion.</h3> —Four of the top 10 characteristics that affect an adolescent's decision to seek care involve cleanliness and infection control. These findings offer providers and planners straightforward, modifiable factors that teens believe influence their decision to seek care. (<i>JAMA</i>. 1995;273:1913-1918)
HEREDITY IN RELATION TO INSANITY AND IDIOCY.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Non-Equilibrium Behavior of Some Brain Enzyme and Receptor Systems
Authors: A. Mandell
Journal: The Annual Review of Pharmacology and Toxicology (1984)

Heme oxygenases (HO) catabolize free heme, that is, iron (Fe) protoporphyrin (IX), into equimolar amounts of Fe2+, carbon monoxide (CO), and biliverdin. The stress-responsive HO-1 isoenzyme affords protection against programmed cell death. The mechanism ...Read More
THE PUBLIC SERVICE.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SYPHILIS.
Authors: JOHN M. BATTEN
Journal: JAMA (1899)

Remembering the old maxim, that "art is long, experience deceptive, and judgment difficult." I herewith offer some questions which are not clear to my mind in the light of my present knowledge: 1. Is syphilis a curable disease, or is it possible to eradicate all the syphilitic germs from a syphilitic? 2, Is not a person once a syphilitic always a syphilitic? 3. Is the germ of tertiary syphilis the same as the germ of secondary syphilis, and also the same germ that causes the chancre? or is their virulency modified by removal from the chancre? 4. Is it possible to inoculate a non-syphilitic by semen, or secretions from a tertiary syphilitic, and produce a syphilitic chancre? 5. Should syphilitics marry? and when? In the light of my present knowledge, I believe syphilis is not an entirely curable disease. While it may be modified by specific and timely treatment, I
The Protein ATG16L1 Suppresses Inflammatory Cytokines Induced by the Intracellular Sensors Nod1 and Nod2 in an Autophagy-Independent Manner
Authors: Matthew T. Sorbara, Lisa K. Ellison, Mahendrasingh Ramjeet, Leonardo H. Travassos, Nicola L. Jones, Stephen E. Girardin, Dana J. Philpott
Journal: Immunity (2014)
Drug-drug interactions (DDIs) with pangenotypic direct-acting antivirals (DAAs) in patients with hepatitis C; understanding the populations at risk and real-world care management
Authors: Michael Curry, Naoky Tsai, Bruce Bacon, Steven Flamm, Zobair Younossi, Scott Milligan, Nicole Wick, Nezam Afdhal
Journal: Journal of Hepatology (2020)
Jewish Contributions to Medicine in America (1656-1934), with Medical Chronology and Bibliography
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Burnout
Authors: Brian Christman
Journal: Annals of Internal Medicine (2021)

Ad LibitumMarch 2021BurnoutBrian Christman, MDBrian Christman, MDVanderbilt University Medical Center, Nashville, TennesseeSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M20-0909 Audio Reading - “Burnout” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads “Burnout” by Brian Christman, MD Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Only those who have been through the abyssCan understand the hollow daysWhen supplying sustenance to the afflictedIs without meaning.Each request a stone stacked on your backAs you swim against the tide,Every required form a scoop by the taxidermistRemoving the coreLeaving form, but not substanceWith shiny crystalline eyesReflecting the light. Author, Article, and Disclosure InformationAffiliations: Vanderbilt University Medical Center, Nashville, TennesseeCurrent Author Address: Brian Christman, MD; e-mail, brian.[email protected]gov. PreviousarticleNextarticle Advertisement Audio Reading - “Burnout” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads “Burnout” by Brian Christman, MD Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics Cited byThe global prevalence of burnout among general practitioners: a systematic review and meta-analysis March 2021Volume 174, Issue 3Page: 436 ePublished: 16 March 2021 Issue Published: March 2021 PDF downloadLoading ...
Fractional Flow Reserve–Guided PCI for Stable Coronary Artery Disease
Journal: New England Journal of Medicine (2014)

notices to the reported death and 2 cases in which there was an additional major bleeding episode that was not related to the death.Of these 22 cases, there were two strokes (one in the group receiving 150 mg of dabigatran twice daily and one in the group receiving warfarin) and 20 episodes of major bleeding (5 in the group receiving 110 mg of dabigatran twice daily, 10 in the group receiving 150 mg of dabigatran twice daily, and 5 in the group receiving warfarin).Major bleeding episodes were considered to be life-threatening in four patients receiving 110 mg of dabigatran, in four patients receiving 150 mg of dabigatran, and in three patients receiving warfarin; such episodes were considered to be fatal in three patients receiving 110 mg of dabigatran, in two patients receiving 150 mg of dabigatran, and in three patients receiving warfarin.All but 2 of these additional events were discovered in patients for whom there was already a death reported.After the inclusion of these events in the RE-LY database, the effects of the two doses of dabigatran, as compared with warfarin, on rates of stroke or systemic embolism and major bleeding were only minimally changed (Table 1).These changes are scheduled for inclusion in the prescribing information for dabigatran.Taken together, these corrections, and the corrections that were reported previously, 2 do not change the conclusions of the study.
Syphilis and leprosy
Authors: K. A. Murray
Journal: JAMA (1982)

<h3>In Reply.—</h3> Dr Murray's letter concerning simultaneous syphilis and HD poses some interesting questions. It is well known that from 10% to 40% of patients with lepromatous leprosy have false-positive reagin serological tests for syphilis.<sup>1</sup>However, in these patients specific treponemal tests such as the FTA-ABS, TPI, and MHA-TP tests are generally negative.<sup>2</sup> Current incidence rates of syphilis in the United States do not approach the percentage of syphilis cases detected in Dr Murray's study population, indicating that patients with HD are at high risk. The highest incidence rate recorded in the United States from 1940 to 1979 for all stages of syphilis was in fiscal year 1943, at a rate of 447/100,000 population.<sup>3</sup>Except for some occasional minor upward fluctuations, the rate for total syphilis in the United States has been steadily declining to a rate of 30.7/100,000 in 1979. Mathematically, 447/100,000 equals 0.447%. This figure
Contempo '87
Authors: Jody W. Zylke
Journal: JAMA (1987)

A physician is a healer, but is also more than a healer. At times, a physician may be a scientist, a counselor, or a social worker; at all times, he or she is a teacher.<i>Physician</i>comes from the Latin word<i>physica</i>, a reminder of our obligation to understand physical nature, but the title "Doctor" by which the physician is called reminds us of another equal obligation—to teach others what we have learned. In CONTEMPO '87, we try to illustrate how the links between medicine and education grow stronger each year. CONTEMPO '87, the ninth issue in the series (which began in 1978), by highlighting the advances in medicine over the last year, serves to inform physicians about progress in specialties outside their own. As in years past, references for more in-depth reading are provided. Because of space limitations, not all areas of medicine can be included each year; those
Abdominal aortic aneurysm: preoperative evaluation
Authors: L. Loo
Journal: JAMA (1993)

<h3>In Reply.</h3> —We greatly appreciate the comments of Drs Loo, Fisher, Castro, and Byrne and wholeheartedly agree that patients should be fully informed about the potential risks and benefits of any planned procedure. There are, however, several points in their statement that must be clarified. The original question and our answer dealt with the preoperative evaluation of patients scheduled for elective (AAA) repair. Our preoperative risk assessment strategy was specifically targeted at this group of patients and was not intended to be used as a general preoperative guideline for all forms of noncardiac vascular surgery. In patients with an AAA, clinical risk factors are age greater than 70 years, diabetes mellitus, angina, abnormal Q-waves on electrocardiogram, and ventricular ectopy. The patients who have three or more of these factors are at high risk of having a postoperative cardiac event with an event rate of 25% as we stated. Patients with
Pathogenesis and Physiopathology of Cystic Fibrosis of the Pancreas
Authors: Paul A. di Sant'Agnese, Richard C. Talamo
Journal: New England Journal of Medicine (1967)

Eccrine Sweat DefectThe eccrine sweat defect in cystic fibrosis was recognized only in 1953,6 relatively late in the history of this disease. A striking increase in the levels of sweat sodium, chloride and to a lesser extent potassium is present in virtually all homozygotic patients with cystic fibrosis and is the most consistent and easily recognizable chemical abnormality in this disease. In contrast most other sweat solutes, as well as the rate of sweating and the response of the sweat gland to most stimuli, appear to be normal or close to normal.Morphology of Eccrine Sweat Glands Morphologically no . . .
Second look at coronary angiography. The evolution of coronary artery disease
Authors: R. J. Mark
Journal: JAMA (1973)

Twenty-eight patients who had two or more coronary angiograms with no intervening surgical procedure were studied in order to evaluate natural progression of coronary artery disease. Various clinical and laboratory data were examined to determine if any of these factors would be helpful in predicting which patients would have an accelerated progression in their coronary lesions. In the criteria studied, no correlation was found. However, we found that progression can occur in as short an interval as five weeks, and that it does not always correlate with symptoms.
From the authors:
Authors: A. Aliverti, M. Quaranta, P. M. Calverley
Journal: European Respiratory Journal (2009)

patients with moderate to severe COPD (36% of moderate to 76% of very severe patients) [3].In my group's own studies, we found that the presence of the paradoxical movement of the lower ribcage was independently associated with a higher degree of dyspnoea (both at rest and after exercise) and higher use of health resources, including hospitalisations [4].For this reason, we proposed the inclusion of this sign among the data useful for predicting outcomes in COPD [5].The paper by ALIVERTI et al.[1] adds interesting information and reinforces the usefulness of including this frequently forgotten sign in the physical examination of COPD patients.
Hypertension
Authors: NORMAN M. KAPLAN
Journal: Annals of Internal Medicine (1972)

Letters, Comments, and Corrections1 March 1972HypertensionNORMAN M. KAPLAN, M.D.NORMAN M. KAPLAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-76-3-511 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The UCLA Conference, "Hypertension—Primary and Secondary" (Ann Intern Med 75:761-776, 1971), has a number of poorly documented and possibly misleading statements. Recognizing that these are transcripts of oral presentations and that the folksy, natural style is refreshing, one could nonetheless ask for a bit more editing to sharpen the accuracy. Surely the authors, recognized authorities in this field, would welcome the chance to clarify some questionable statements."It is now acknowledged that perhaps 5%, 10%, or, at the most, 15% of hypertensive subjects" have primary aldosteronism. The latest estimate by the Michigan group is 7% (1) and...References1. CONN J: The evolution of primary aldosteronism—1954-1967. Harvey Lect 62:257-291, 1968 Google Scholar2. LARAGH J, SEALEY J, and SOMMERS S: Patterns of adrenal secretion and urinary excretion of aldosterone and plasma renin activity in normal and hypertensive subjects. Circ Res 18 (suppl 1):158-174, 1966 Google Scholar3. FISHMAN L, KUCHEL O, and LIDDLE G: Incidence of primary aldosteronism upcomplicated "essential" hypertension. JAMA 205:497-502, 1968 CrossrefMedlineGoogle Scholar4. SCHONBECK M, SIEGENTHALER W, and WEIDMANN P: Correlation of plasma renin activity and aldosterone secretion rate in hypertensive patients. Helv Med Acta 34:386-400, 1969 MedlineGoogle Scholar5. MELBY J, DALE S, and WILSON T: 18-hydroxy-deoxycorticosterone in human hypertension. Circ Res 28 (suppl II):143-152, 1971 CrossrefGoogle Scholar6. CRYER P and SODE J: Drug interference with measurement of adrenal hormones in urine: analgesics and tranquilizer-sedatives. Ann Intern Med 75:697-702, 1971 LinkGoogle Scholar7. GITLOW S, MENDLOWITZ M, and BERTANI L: The biochemical techniques for detecting and establishing the presence of a pheochromocytoma. Am J Cardiol 26:270-279, 1970 CrossrefMedlineGoogle Scholar8. BROWN J, CHINN R, and DAVIES D: Plasma electrolytes, renin, and aldosterone in the diagnosis of primary hyperaldosteronism. Lancet 2:55-59, 1968 CrossrefGoogle Scholar1. ENGELMAN K: Principles in the diagnosis of pheochromocytoma. Bull NY Acad Med 45:851-858, 1969 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: NORMAN M. KAPLAN, M.D.Affiliations: Department of Internal Medicine The University of Texas Medical School Dallas, Tex. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1972Volume 76, Issue 3Page: 511-512KeywordsHypertension ePublished: 1 December 2008 Issue Published: 1 March 1972 PDF downloadLoading ...
Knots
Authors: M. T. Cooper
Journal: JAMA (1981)

<h3>To the Editor.—</h3> I really must correct so glaring an error as that contained in Dr Ratzan's article on knots. The caduceus with two twining branches or snakes is properly associated with Hermes or Mercury, and they in turn are properly associated with trade. Asklepios or Aesculapius is the god of medicine, and he carries a staff with a serpent coiled round it.