tbuckley/cabot-search huggingface dataset:
Position statement on substance-related disorders
Journal: American Journal of Psychiatry (1996)

Substance-related disorders are widespread among the general public and are often accompanied by other psychiatric disorders. However, historical social stigma and other factors have led to underdiagnosis and limited access to care. Cost-effective treatment is best delivered in a comprehensive, flexible continuum of services, which should be accessible on the same basis as other medical care. The American Psychiatric Association should continue to promote access to care, high-quality treatment, education, training, research, parity in third-party coverage, and equal treatment for patients suffering from addictive disorders. This statement was drafted by the Task Force on Psychiatric Services for Addicted Patients. It was approved by the Assembly in November 1995 and by the Board of Trustees in December 1995.
VAGINAL SECTION.
Authors: LEWIS SCHOOLER
Journal: JAMA (1897)

years of age, were regular, of fair quantity and slightly painful.The last two periods had differed however, the first being very scant and of short duration, while the last had been continuous during the four weeks previous to admission.She complained of severe pain in the lower part of the abdomen and of great weakness.An examination revealed blanched mucous mem branes, great emaciation, a very frequent and small pulse and rapid respiration.A mass was found extending from the pelvis behind the uterus, upward about 7 cm.above the pubes, very sensitive to the touch and slightly fluctuating.The uterus was found to be slightly enlarged, fixed anteriorly and above its usual plane.The lower part of the mass was quite soft and encroached on the vagina.September 24 vaginal puncture was made and two liters of solid and fluid blood with fetal membranes evacuated.Free irrigation of the cavity was done and as no bleeding was pres- ent, nothing further was deemed necessary.The left append age was found very much enlarged and ragged, but was not disturbed but packed for a few days with iodoform gauze.Two weeks later she sat out of bed and was allowed to go home one week later, though the left tube was still enlarged.Case 5.-Mrs.-hadhad four children and one abortion, but
CARL WEIGERT (1845-1904)
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Allogeneic Transplantation of Normal Epidermal Cells and Squamous Cell Carcinomas in SENCAR Mice
Authors: Claudio J. Conti, JoAnn W. Fries, Claudio M. Aldaz, Andres J. P. Klein-Szanto, Thomas J. Slaga
Journal: Environmental Health Perspectives (1986)

A method used in our laboratory for the transplantation of single cell suspensions of epidermis and skin carcinomas is described. Silicone chambers were placed into a subcutaneous granulation tissue formed by the implantation of a glass disk. The skin was closed on top of the chamber by using Michael autoclips. Cells were injected 24 to 48 hr later through the skin using a syringe and needle. The neoformation of epithelia with adnexa was observed when newborn epidermal cells were injected. When a fresh cell suspension of squamous cell carcinoma was used, a typical differentiated carcinoma was formed within 2 to 4 weeks. However, after 4 weeks, some of the grafts showed mild signs of rejection. The technique described is a useful system to transplant squamous cell carcinomas and can also be used as a rapid assay for malignancy.
Inhibition of anaphylatoxin C3a- and C5a- but not nerve stimulation- or Noradrenaline-dependent increase in glucose output and reduction of flow in Kupffer cell-depleted perfused rat livers
Authors: G Puschel
Journal: Hepatology (1996)

In isolated in situ perfused rat livers, infusion of anaphylatoxins C3a and C5a, activation peptides of the complement system, as well as stimulation of sympathetic hepatic nerves have been shown to increase hepatic glucose output and to reduce hepatic flow. These effects were mediated via an at least partially prostanoid-dependent intercellular signalling chain between nonparenchymal cells and hepatocytes. Kupffer cells have been implicated as the source of prostanoids in the anaphylatoxin-dependent signalling chain and Ito cells in the nerve stimulation-dependent signalling chain, because anaphylatoxins and noradrenaline increased prostanoid synthesis in isolated Kupffer and Ito cells, respectively. To further corroborate this hypothesis, anaphylatoxins were infused and hepatic nerves were stimulated in perfused rat livers in which Kupffer cells had been largely depleted by treatment of the animals with gadolinium chloride. Native human anaphylatoxin C3a (nhC3a) and recombinant rat anaphylatoxin C5a (rrC5a) increased prostanoid formation as well as glucose output and reduced flow in perfused rat liver. In Kupffer cell-depleted rat livers, the nhC3a- and rrC5a-mediated prostanoid formation was nearly abolished, and the increase in glucose output and the reduction of flow were reduced to between 30% and 50% (area under the curve [AUC]) of control livers. In contrast, stimulation of hepatic nerves increased glucose output and reduced flow to a similar extent in Kupffer cell-depleted livers as in control livers. These results indicate that Kupffer cells were not involved in the prostanoid-mediated nerve stimulation-dependent increase in glucose output and reduction of flow. Kupffer cells seemed, however, to be at least one major source of the anaphylatoxin-mediated prostanoid formation and, consequently, stimulation of glucose release and flow reduction in perfused liver. Because the metabolic and hemodynamic anaphylatoxin effects were not completely blocked in livers of gadolinium-treated animals, either Kupffer cells may not have been entirely eliminated, or yet another nonparenchymal cell type and mediator might be involved in the anaphylatoxin-elicited intercellular communication between nonparenchymal cells and hepatocytes.
THE MANNER OF INFECTION IN BUBONIC PLAGUE.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Peripheral Nerve Regeneration
Authors: J W Fawcett, R J Keynes
Journal: Annual Review of Neuroscience (1990)

The brain's default mode network consists of discrete, bilateral and symmetrical cortical areas, in the medial and lateral parietal, medial prefrontal, and medial and lateral temporal cortices of the human, nonhuman primate, cat, and rodent brains. Its ...Read More
Surgical Technique
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AMERICAN GYNECOLOGY.
Journal: JAMA (1889)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A false phoenix
Journal: BMJ (1986)

I wonder if I might add some points to Dr Linda Beeley's answer on whether antibiotic drugs reduce the effectiveness of oral contraceptives (22 February, p 528).Rifampicin is known to induce hepatic enzymes and this can cause a reduction in the effectiveness of anticoagulants, corticosteroids, digitalis preparations, oral contraceptives, and oral hypoglycaemic agents.'Pregnancies have apparently resulted from this interaction.2 3In the data sheet for rifampicin it is recommended that women taking oral contraceptives should use an alternative, non-hormonal method of contraception during rifampicin treatment.4Although UK product licences do not allow the recommenda- tion of rifampicin for treatment ofany condition other than tuberculosis, it is known to be used in (among others) short course prophylaxis for contact with meningococcal meningitis.Enzyme induction has been shown to occur in a matter of days,5 and the warning should also be given to patients treated with short course prophylaxis.1 Acocella G, Conti R. Interaction of rifampicin with other drugs.
Comparison of the clinical impact of endoscopic ultrasound-guided choledochoduodenostomy and hepaticogastrostomy for bile duct obstruction with duodenal obstruction
Authors: Takeshi Ogura, Yasutaka Chiba, Daisuke Masuda, Masayuki Kitano, Tatsushi Sano, Onda Saori, Kazuhiro Yamamoto, Hiroshi Imaoka, Akira Imoto, Toshihisa Takeuchi, Shinya Fukunishi, Kazuhide Higuchi
Journal: Endoscopy (2015)

Correction to: Comparison of the clinical impact of endoscopic ultrasound-guided choledochoduodenostomy and hepaticogastrostomy for bile duct obstruction with duodenal obstructionEndoscopy 2016; 48(02): 156-163DOI: 10.1055/s-0034-1392859
QUARANTINE APPROPRIATIONS.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Practical Observations on 'Supporting the Perinaeum.'
Authors: G. Hewitt
Journal: BMJ (1861)

or relatively, of any one of these, or of two or more By i + T Un W + associated, is sufficient to produce laceration.It is impossible to dissociate all these elements ON in arriving at a real conclusion as to the cause of 'SUPPORTING THE PERIN.iUI." the laceration in a particular case, as will be at once admitted on looking the facts fairly in the face.13Y Thus, when we are told that "great size of the GRAILY HEWITT, M.D., M.R.C.P., child's head" was the cause in a particular instance, 'HYSICIANT TO THE BRITISH LYING-IN HOSPITAL; LECTURER ON this may convey but a very small part of the truth.
Racial inequalities in the use of procedures for ischemic heart disease
Authors: M. D. Holmes
Journal: JAMA (1989)

<h3>To the Editor. —</h3> We commend the study by Drs Wenneker and Epstein<sup>1</sup>entitled "Racial Inequalities in the Use of Procedures for Patients With Ischemic Heart Disease in Massachusetts" in the January 13 issue of<i>JAMA</i>. However, both the authors and the subsequent media coverage obscured the most important point: the most likely reason for these inequalities is that physicians value black lives less than white lives. We are physician-researchers. We recognize that in scientific studies, the cause of a finding is rarely established beyond a shadow of a doubt. We also recognize the need to consider alternative hypotheses, usually in decreasing order of likelihood, that would explain the observed effect. The authors stress the hypothesis that black patients are less likely to accept surgery and other technological interventions when offered. They refer to this as a "cultural difference." This comes dangerously close to blaming the victim. The cultural
Brain tumors in the elderly
Authors: T. Tomita
Journal: JAMA (1981)

Eighty patients older than 65 years underwent craniotomy for primary or secondary brain tumors. Glioblastoma was the most common tumor, followed by metastatic carcinoma and meningioma. Three patients died within 30 days of surgery. Twenty-three patients showed development of postoperative systemic complications, of which pulmonary complications were most common. Thirty-seven (44%) of the patients showed significant improvement, but 13 (21%) became worse after surgery. Most brain tumors in elderly patients are operable. However, the surgical indications should be determined by the nature of the tumor and the condition of the individual patient. Preoperative and postoperative management must be more demanding if systemic complications are to be avoided. (<i>JAMA</i>1981;246:53-55)
Immunomodulation by HDAC inhibition: Results from a phase II study with entinostat and high-dose interleukin 2 in metastatic renal cell carcinoma patients (CTEP#7870).
Authors: Roberto Pili, David I. Quinn, Hans J. Hammers, Paul Monk, Saby George, Tanya B. Dorff, Thomas Olencki, Li Shen, Dominick M Lamonica, Alan Hutson, Adrienne Groman, Richard Piekarz, Michael Anthony Carducci
Journal: Journal of Clinical Oncology (2016)

4560 Background: Immunosuppressive factors such as regulatory T cells (Tregs) and myeloid-derived suppressive cells (MDSCs) limit the efficacy of immunotherapies. Histone deacetylase (HDAC) inhibitors have been shown to have immunomodulatory effects. We have previously reported that the class I selective HDAC inhibitor entinostat has synergistic antitumor effects in combination with high dose interleukin-2 (IL-2) in a renal cell carcinoma model by down-regulating Foxp3 expression and function of Tregs. Thus, we have conducted a Phase I/II clinical study with entinostat and high dose IL-2 in patients (pts) with metastatic clear cell renal cell carcinoma. Methods: The primary objectives were to evaluate the safety, tolerability and efficacy of this combination strategy. The main eligibility criteria were clear cell histology, no prior treatments, and being fit to receive high dose IL-2. The phase I portion consisted of two dose levels of entinostat (3 and 5 mg, PO every 14 days) and a fixed standard dose of IL-2 (600,000 units/kg every 8 hrs). To test our hypothesis, the fixed sample size at the Phase II dose level is 36 with a type I/II error of 10%. If 11 or more of the pts have a response, the hypothesis that the response rate is ≤ 20% is rejected. Results: Dose levels 1 and 2 were completed without DLTs and 5 mg was the Phase II recommended dose for entinostat. The most common transient grade 3/4 toxicities were hypophosphatemia (16%). lymphopenia (15%), and hypocalcemia (7%) We have enrolled 47 pts (44 at dose level 2), and 38 have completed one cycle (84 days) treatment. Four pts were not evaluable. 13 pts have achieved objective response (34%; 10 PR, 3 CR). The overall median PFS is 16.1 months (6.2, 27.8) and the median PFS of responders is 28.5 months (12,NR). To date the median OS is 65.3 months (52.6, 65.3). Decreased Tregs have been observed following treatment and lower numbers have been associated with response. Conclusions: The results from this clinical trial suggest that entinostat may increase the therapeutic effect of high dose IL-2 by modulating immunosuppressive cells. Clinical trial information: NCT01038778.
Clinical Summaries
Journal: Circulation (2009)

Serum Long-Chain n-3 Polyunsaturated Fatty Acids and Risk of Hospital Diagnosis of Atrial Fibrillation in MenFish consumption has been associated with reduced risk of atrial fibrillation (AF) and the long-chain n-3 polyunsaturated fatty acids (PUFAs) in fish have been suggested to account for the beneficial effects.The present study assessed the relationship between serum concentrations of long-chain n-3 PUFAs eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA) and docosahexaenoic acid (DHA), which also serve as a marker of fish or fish oil consumption, and risk of AF in middle-aged or older men in Eastern Finland.During 17.7 years of follow-up, 240 men from the total cohort of 2174 men experienced an AF event that required hospitalization.Men in the highest quartile of serum EPAϩDPAϩDHA had a 35% lower risk of AF compared with men in the lowest quartile.Of the individual fatty acids, only serum DHA was associated with the risk, with a 38% lower risk in the highest quartile.No association with the risk was found with serum intermediate chain-length n-3 PUFA, alpha-linolenic acid, not even when the serum EPAϩDPAϩDHA concentration was low.Although previous studies in this study population have shown an association between long-term low-level mercury exposure and risk of cardiovascular diseases, high mercury concentration in hair was not associated with the risk of AF in this study.In summary, long-chain n-3 PUFAs, and especially DHA, may be effective in reducing the risk of AF in men.See p 2315.
Antibiotic Selection
Authors: Frederick B. Traub
Journal: JAMA (1967)

<h3>To the Editor:—</h3> The article of Gantner and Laskowski (<b>200</b>:431,1967), entitled "Antibiotic Selection Based Upon Immediately Available Data," failed to take into account several important points. Many institutions are beginning to program computers for instant retrieval of laboratory data, particularly antibiotic susceptibility results. While information thus available is a valuable adjunct to our general knowledge of antibiotic activity it can not and should not be used to supplant judgment based on a knowledge of clinical and microbiologic principles of antibiotic action. Two serious errors are immediately evident. In the work sheet illustrated trade names are often used instead of generic names, and thus, antibiotics with identical in vitro activities are listed separately, eg, Ilosone-erythromycin, and Staphcillin-Prostaphlin. In the prediction report form, illustrating a report on a sample of sputum, nitrofurantoin (Furadantin) is classified as 98% sensitive. This could lead an inexperienced clinician to choose this drug although nitrofurantoin should
Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species
Authors: Li Qian, Joshua D. Wythe, Jiandong Liu, Jerome Cartry, Georg Vogler, Bhagyalaxmi Mohapatra, Robyn T. Otway, Yu Huang, Isabelle N. King, Marjorie Maillet, Yi Zheng, Timothy Crawley, Ouarda Taghli-Lamallem, Christopher Semsarian, Sally Dunwoodie, David Winlaw, Richard P. Harvey, Diane Fatkin, Jeffrey A. Towbin, Jeffery D. Molkentin, Deepak Srivastava, Karen Ocorr, Benoit G. Bruneau, Rolf Bodmer
Journal: The Journal of Experimental Medicine (2011)
General surgery
Authors: C. H. Organ
Journal: JAMA (1995)

Ambulatory surgery, a landmark innovation driven by payment system changes, now accounts for approximately 50% of all surgery in the United States. It produces outcomes equivalent to those of inpatient surgery at considerable per-patient savings. This represents a dramatic shift in the locus of providing surgical care. In 1995, more than 3.5 million endoscopic procedures will be performed in ambulatory surgery units. Ambulatory surgery has achieved its quality-enhancing and cost-saving potential.<sup>1</sup> In a prospective, randomized evaluation of parietal cell vagotomy and selective vagotomy with antrectomy for the treatment of duodenal ulcer complications, Jordan and Thornby<sup>2</sup>found both procedures to be effective and safe operations when used appropriately. Selective vagotomy with antrectomy is preferable for patients with pyloric and prepyloric ulcers and those with pyloric obstruction. Meisner et al<sup>3</sup>from Denmark studied the long-term recurrence rate after parietal cell vagotomy in duodenal, pyloric, and prepyloric ulcers. Of 350