tbuckley/cabot-search huggingface dataset:
Two Different Breast Cancer Screening Strategies Are Equally Effective
Journal: JNCI Journal of the National Cancer Institute (2008)

Two Different Breast Cancer Screening Strategies Are Equally EffectiveAn organized population-based breast cancer screening program in Norway and an approach to screening that relies on physician-and self-referrals in Vermont are equally sensitive for detecting cancer, researchers report in the July 29 online issue of the Journal of the National Cancer Institute .But the recall rate for abnormal mammograms was lower in Norway.
Enlarged jugular foramen
Authors: A. E. James
Journal: JAMA (1968)

Dr. Robert F. Rider: A 25-year-old white woman noted a mass in the right side of her neck that had increased in size for three years. The patient stated that she experienced diminished hearing and later deafness, pain over the right mastoid, serous discharge from the right ear, and, most recently, hoarseness and difficulty in swallowing. Her husband had noted facial asymmetry and also that her right pupil was smaller than the left. She described a feeling of "tiredness" of the entire right side of her face. The feeling had persisted for the past five months. Physical examination revealed a Horner's syndrome on the right, negative vestibular response, auditory nerve deafness on the right, deviation of the palate and tongue to the right, and paralysis of the right facial nerve. A firm, immobile, nontender 10 × 6-cm mass was palpable from the mastoid process to the right mandibular angle. On
Survival after cardiopulmonary resuscitation
Authors: G. A. Hofkin
Journal: JAMA (1967)

Survival after cardiopulmonary resuscitation was studied in 78 cases. The long-term survival rate of 12% was double that of a previous report from this same hospital. Training of nursing personnel in resuscitation fundamentals appeared as one factor in the improved survival. Postresuscitation critiques allowed detection of errors in technique. It was found that diagnosis of primary respiratory arrest was obscured by early use of mechanical ventilators. Use of mouth-to-mouth or bag breathing during the early resuscitation efforts helped overcome this problem.
Editorial Board
Authors: Bruce Thiers, Dirk Elston, Detra Davis, Kenneth Katz, Jack Lesher, Mary Spellman, Jeffrey Weinberg, Dermatologic Surgery, Clifford Perlis, Julie Prendiville, Frcpc Dermatopathology, John Maize, Social Media, Emily Altman, Robert Dellavalle, J Smith, Editors Emeritus, Richard Dobson, Jeffrey Bernhard, Calvin Mccall, Brett Sloan, James Solomon, Stephen Tyring, George Hruza, Pediatric Dermatology, Kelly Cordoro, Dermatopathology Carlson, Tammie Ferringer, Cyberdermatology Consultant, Daniel Siegel, Clara Kim, Bryan Anderson, Salvador Arias-Santiago, Trisha Beute, John Binhlam, Diana Bolotin, Markus Braun-Falco, Nooshin Brinster, Patrick Carrington, Zoe Draelos, Nananamibia Duffy, Laura Ferris, David Fivenson, Joel Gelfand, Camille Introcaso, Nathaniel Jellinek, Jonathan Kantor, Matthew Kanzler, Kevin Kia, Nikki Levin, Kenneth Linden, Jason Lott, Omar Lupi, J Am, Acad Dermatol
Journal: Journal of the American Academy of Dermatology (2016)
International Cancer Research Technology Transfer Program (ICRETT)
Journal: JNCI Journal of the National Cancer Institute (1985)

Journal Article International Cancer Research Technology Transfer Program (ICRETT) Get access JNCI: Journal of the National Cancer Institute, Volume 75, Issue 2, August 1985, Page 395, https://doi.org/10.1093/jnci/75.2.395-b Published: 01 August 1985
GENERALIZED VACCINIA OF ERUPTIVE TYPE.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Consensus conference. Urinary incontinence in adults
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Antiviral activity, pharmacokinetics and safety of the second-generation hepatitis B core inhibitor ABI-H2158 in Phase 1b study of patients with HBeAg-positive chronic hepatitis B infection
Authors: Kosh Agarwal, Junqi Niu, Yanhua Ding, Edward Gane, Tuan Nguyen, Katia Alves, Marc Evanchick, Hany Zayed, Qi Huang, Steven Knox, Luisa Stamm, Richard Colonno, Tarek Hassanein, Dong Joon Kim, Young-Suk Lim, Man-Fung Yuen
Journal: Journal of Hepatology (2020)
Powdered tantalum. A new contrast medium for roentgenographic examination of human airwaysNadel, J. A., Wolfe, W. G., Graf, P. D., Youker, J. E., Zamel, N., Austin, J. H. M., Hinchcliffe, W. A., Greenspan, R. H., and Wright, R. R.: New Eng. J. Med. 283: 281, 1970
Journal: Journal of Allergy and Clinical Immunology (1971)
How It Strikes the Country Practitioner.
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
LUPUS ERYTHEMATOSUS
Authors: HENRY WALDO
Journal: British Journal of Dermatology (1901)

Journal Article LUPUS ERYTHEMATOSUS Get access HENRY WALDO, M.D., M.R.C.P. HENRY WALDO, M.D., M.R.C.P. Physician to the Bristol ‘Royal Infirmary and in charge of the Department for Skin Diseases Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 13, Issue 8, 1 August 1901, Pages 292–300, https://doi.org/10.1111/j.1365-2133.1901.tb16393.x Published: 01 August 1901
First Real-World Effectiveness Analysis of Preschool Peanut Oral Immunotherapy
Authors: Lianne Soller, Elissa Abrams, Stuart Carr, Sandy Kapur, Gregory Rex, Per Lidman, Timothy Vander Leek, Joanne Yeung, Mary McHenry, Tiffany Wong, Victoria Cook, Kyla Hildebrand, Thomas Gerstner, Raymond Mak, Elaine Hsu, Scott Cameron, Edmond Chan
Journal: Journal of Allergy and Clinical Immunology (2020)
Efficient Whole-body Transduction with Trans-splicing Adeno-associated Viral Vectors
Authors: Arkasubhra Ghosh, Yongping Yue, Chun Long, Brian Bostick, Dongsheng Duan
Journal: Molecular Therapy (2007)

Limited packaging capacity has hampered adeno-associated virus (AAV)-mediated gene therapy for many common genetic diseases such as cystic fibrosis (CF) and Duchenne muscular dystrophy (DMD). Trans-splicing AAV (tsAAV) vectors double AAV packaging capacity but their transduction efficiency has been too low to be useful. We have recently overcome this hurdle by rational vector design. We have shown that a pair of optimized mini-dystrophin tsAAV vectors can reach the same transduction efficiency as that of a single AAV vector after local injection in dystrophic muscle. However, global gene transfer is required to treat diseases like DMD. To test whether systemic delivery can be achieved with tsAAV vectors, we generated a set of optimized alkaline phosphatase (AP) tsAAV vectors. We delivered AAV serotype 9 pseudotyped AP tsAAV intravenously to newborn mice. Six weeks later, we observed high-level transduction in all body skeletal muscle and the heart, the tissues that are affected in DMD. We also detected efficient transduction in the lung, the primary organ affected in CF. Our results provide the first evidence of whole-body transduction with tsAAV vectors and further raise the hope of tsAAV gene therapy for DMD and CF. Limited packaging capacity has hampered adeno-associated virus (AAV)-mediated gene therapy for many common genetic diseases such as cystic fibrosis (CF) and Duchenne muscular dystrophy (DMD). Trans-splicing AAV (tsAAV) vectors double AAV packaging capacity but their transduction efficiency has been too low to be useful. We have recently overcome this hurdle by rational vector design. We have shown that a pair of optimized mini-dystrophin tsAAV vectors can reach the same transduction efficiency as that of a single AAV vector after local injection in dystrophic muscle. However, global gene transfer is required to treat diseases like DMD. To test whether systemic delivery can be achieved with tsAAV vectors, we generated a set of optimized alkaline phosphatase (AP) tsAAV vectors. We delivered AAV serotype 9 pseudotyped AP tsAAV intravenously to newborn mice. Six weeks later, we observed high-level transduction in all body skeletal muscle and the heart, the tissues that are affected in DMD. We also detected efficient transduction in the lung, the primary organ affected in CF. Our results provide the first evidence of whole-body transduction with tsAAV vectors and further raise the hope of tsAAV gene therapy for DMD and CF.
The Somnos Habit.
Authors: None H. B.
Journal: JAMA (1907)

Philadelphia, June 10, 1907. <h3>To the Editor:</h3> —I have been consulted recently for a condition that I think should be given publicity through the columns ofThe Journal. A fellow practitioner called me in consultation under the following conditions: He was attending a woman in the higher walks of life who was, unfortunately, a victim of the morphin habit. By skilful treatment he had almost effected a cure, when he noticed some peculiarities suggestive of the use of a narcotic, but could not ascertain positively what and how the suspected agent was being used. One evening the patient was found unconscious, with weak, depressed circulation, reduced temperature, embarrassed respiration, in a word, in profound narcotism, and the character of the symptoms showed that it was unquestionably the profound narcosis of chloral. Investigation subsequently showed that one of her employés had been bribed to obtain Somnos from a druggist who should
Abstract 2107: Seeing glycolysis on PDAC: Applying deep learning convolutional neural network model
Authors: Peiling Tsou, Chang-Jiun Wu
Journal: Cancer Research (2020)

Abstract The reprogramming of cellular metabolism to support continuous proliferation is a hallmark of cancer. Accumulating evidence indicates that the reprogramming of tumor metabolism is under the control of various oncogenic signals. The Kras oncogene is known to induce aerobic glycolysis, and pancreatic adenocarcinoma (PDAC) cells have been shown previously to have metabolism consistent with elevated aerobic glycolysis. Several glycolytic inhibitors are currently in preclinical and clinical development. It had been reported that cancer metabolic status could play a role in the interaction with tumor microenvironment. We hypothesized that cancer glycolysis activity could affect tumor-stromal interaction in PDAC. As a proof-of-concept study, we trained a deep learning convolutional neural network (CNN) model (Google Inception v3) on histopathologic images obtained from The Cancer Genome Atlas (TCGA) PDAC cohort to classify tumors with high and low glycolysis pathway activity. We aimed to answer whether CNNs can predict PDAC glycolysis status using images as the only input. The accuracy on independent validation set is 77.4% with area under ROC curve as 0.698 (Pearson correlation=0.418, p=0.026). Survival analysis showed that higher glycolysis activity was associated with worse clinical outcome in TCGA PDAC. The current study demonstrates the potential of deep learning approaches for histopathologically classifying cancer based on metabolic status. This information could be of value in assisting clinical decisions on targeting cancer metabolism. Citation Format: Peiling Tsou, Chang-Jiun Wu. Seeing glycolysis on PDAC: Applying deep learning convolutional neural network model [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 2107.
Erratum to: Genomic Insights into the Origin and Evolution of Molluscan Red-Bloodedness in the Blood Clam <i>Tegillarca granosa</i>
Authors: Yongbo Bao, Qifan Zeng, Jing Wang, Zelei Zhang, Yang Zhang, Sufang Wang, Nai-Kei Wong, Wenbin Yuan, Yiyi Huang, Weifeng Zhang, Jing Liu, Liyuan Lv, Qinggang Xue, Shanjie Zha, Zhilan Peng, Hanhan Yao, Zhenmin Bao, Shi Wang, Zhihua Lin
Journal: Molecular Biology and Evolution (2021)
Obituary Listing
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
List of Tuberculosis Hospitals.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Parallel 2: Antivirals, Acute Liver Failure in Liver Transplantation
Authors: Bryan Fuchs, Christian Farrar, Danielle Deperalta, Helen Day, Boris Keil, Gregory Lauwers, Lan Wei, Arun Subramaniam, Bashar Aqel, Surakit Pungpapong, K Werner, Amy Chervenak, Jorge Rakela, Kymberly Watt, Michael Leise, Jennifer Murphy, Tanisha Henry, Kristen Ryland, Andrew Keaveny, Hugo Vargas
Journal: Hepatology (2014)

tent.Results: Collagen deposition in response to BDL increased over time as assessed by Hyp analysis and Sirius red staining.Compared to sham controls, liver ΔR1 increased significantly in BDL rats at 10 and 18 days (p=0.04 and p<0.01, respectively).Liver ΔR1 also correlated with ex vivo Gd concentration (R=0.65).Rapamycin inhibited biliary fibrosis progression as measured by Sirius red staining (p<0.01).Consistently, a significant decrease in ΔR1 was observed in BDL rats that received rapamycin (p=0.01).Interestingly, marked heterogeneity was observed by Sirius red staining between the left and right lobes of a "non-responder" rapamycin-treated rat, and this difference was detected on the ΔR1 maps.Conclusion.Quantitative 3D ΔR1 maps can be used to monitor progression of biliary fibrosis throughout the entire liver, and ΔR1 is sensitive to changes in liver fibrosis in response to rapamycin treatment.EP-3533 should be examined for its ability to image liver fibrosis in humans.
Effects of Chrysotile Co-Exposure on BaP Binding in Normal Human Fibroblasts
Authors: Ming J. W. Chang, Narendra P. Singh, Ronald W. Hart
Journal: Environmental Health Perspectives (1983)

The effects of chrysotile and benzo(a)pyrene (BaP) co-exposure on uptake, metabolism and BaP binding to nucleic acids were investigated in normal human fibroblasts. A significant enhancement in these parameters was found when co-exposure was carried out under serum-free conditions. In the presence of serum, only a slight enhancement of BaP uptake was detected, while metabolism and binding to nucleic acids were not affected over the 8-hr incubation period studied.
Relationship between stimulating mechanisms of gastric secretion in dogs
Authors: P. J. Jordan
Journal: JAMA (1967)

Observations by Straaten<sup>1</sup>and Unvas<sup>2</sup>suggested that the cephalic phase of gastric secretion was dependent on a neurohumoral mechanism originating in the antrum. Thein and Schofield<sup>3</sup>later provided critical evidence to support the concept that gastric secretion in response to vagal stimulation was partly due to vagal release of gastrin. Subsequently, it was demonstrated by Olbe<sup>4</sup>and ourselves<sup>5</sup>that antrectomy reduced the secretory response to cephalic stimulation by sham feeding. Olbe<sup>6</sup>further showed that administration of a subthreshold dose of gastrin restored to normal the sham feeding response reduced by antrectomy. That only a small amount of gastrin was required to permit full vagal response of parietal cells was suggested further by our work which estimated that vagally released gastrin approximated 16% of that released by direct chemical stimulation of the antrum.<sup>5</sup> The present experiments were designed to study further potentiation of acid
"CROWNER'S QUEST LAW."
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Error in Table 3
Journal: JAMA Internal Medicine (2014)

Anne M. Walling, MD, PhD; Diana Tisnado, PhD; Steven M. Asch, MD, MPH; Jennifer M. Malin, MD, PhD; Philip Pantoja, MA; Sydney M. Dy, MD; Susan L. Ettner, PhD; Ann P. Zisser, RN; Hannah Schreibeis-Baum, MPH; Martin Lee, PhD; Karl A. Lorenz, MD, MSHS
Melanoma
Authors: Daniel G. Coit, Robert Andtbacka, Christopher J. Anker, Christopher K. Bichakjian, William E. Carson, Adil Daud, Raza A. Dilawari, Dominick DiMaio, Valerie Guild, Allan C. Halpern, F. Stephen Hodi, Mark C. Kelley, Nikhil I. Khushalani, Ragini R. Kudchadkar, Julie R. Lange, Anne Lind, Mary C. Martini, Anthony J. Olszanski, Scott K. Pruitt, Merrick I. Ross, Susan M. Swetter, Kenneth K. Tanabe, John A. Thompson, Vijay Trisal, Marshall M. Urist
Journal: Journal of the National Comprehensive Cancer Network (2012)

In 2010, an estimated 68,130 new cases of melanoma were diagnosed and approximately 8700 patients died of the disease in the United States. 1 However, these figures for new cases may represent a substantial underestimation, because many superficial and in situ melanomas treated in the outpatient setting are not reported.The incidence of melanoma continues to increase dramatically.Melanoma is increasing in men more rapidly than any other malignancy, and in women more rapidly than any other malignancy except lung cancer.For someone born in the United States in the year 2005, the lifetime risk for developing melanoma may be as high as 1 in 55. 2 The median age at diagnosis is 59 years.Therefore, melanoma ranks second to adult leukemia in terms of loss of years of potential life, per death.