tbuckley/cabot-search huggingface dataset:
ANGINA PECTORIS
Authors: William Martin
Journal: JAMA (1924)

<h3>To the Editor:</h3> —InThe Journal, September 20, the current comment on "Angina Pectoris" attracted my attention. The statement is made that the multiplicity of theories of its causation demonstrates the lack of unanimity. There is a class of anginas with all the earmarks of true angina, accurring in persons past middle life, in whom there are circulatory disturbances and the usual clinical features of this syndrome. If properly tested for left brachial neuritis, a large number or all of these will respond to the test. A definite diagnosis of neuritis may be made and thus the patient's mind relieved of fear of the more dangerous disease. We know that the left brachial plexus has a cardiac branch, and such a neuritis will convey all or practically all the symptoms of an angina. To test, I use the static wave current, placing an electrode over the area. As the current
Aldosteronism in Man
Authors: Jerome W. Conn
Journal: JAMA (1963)

STUDIES upon the mechanism by which normal<sup>1</sup>men acclimatize to heat, carried out in our laboratory between 1943 and 1946, gave information which was responsible for the recognition of primary aldosteronism as a clinical entity. This included evidence that: In the process of heat adaptation an endogenous desoxycorticosterone-like steroid is produced in large amounts as reflected in decreasing concentrations of sodium in thermal sweat. Administered desoxycorticosterone produced the same effects. Increased steroidal activity of this type continued in the absence of evidence of increased activity of the adrenal cortex in other respects. The ability of the acclimatizing man to maneuver himself into a condition of positive sodium balance, despite large sweat volumes, was accomplished by an integrated response of the kidney and sweat glands with respect to salt conservation, and that this was mediated by increased activity of the endogenous desoxycorticosteronelike steroid. Renal escape from
Abstract 17568: Phospholipase C Gamma-1 Mediated Akt-notch1 Signaling is Essential for Intima Formation
Authors: Jianhui Zhuang, Dongyang Jiang, Wenhui Peng, Yuyan Lu, Qian Zhao, Lin Gao, Chen Chi, Xiangbing Xu, Chen Yan, Yawei Xu, Junbo Ge, Jinjiang Pang
Journal: Circulation (2015)

Introduction: Vascular smooth muscle cell (VSMC) proliferation, migration and dedifferentiation are critical for vascular diseases, such as atherosclerosis and restenosis after angioplasty. Recently, it is demonstrated that after vascular injury Notch 1and Notch 3 knockout (KO) mice have decreased intima formation whereas Notch 2 KO mice have increased one. Therefore, it is important to investigate the specific regulatory pathways that activate the different Notch receptors. Methods and Results: There was a time and dose dependent activation of Notch1, as determined by western blot of N1-ICD but not Notch 2 and 3 in VSMC. As Akt activates Notch signaling in endothelial cells and phospholipase C gamma-1 (PLCγ1) binds to and activates Akt in tumor cells, we therefore propose that PLCγ1 mediated Akt -Notch1 pathway is critical for intima formation by increasing VSMC proliferation, migration and dedifferentiation. To test our hypothesis, we measured PLCγ1 and Akt interaction in VSMC. We observed an association between PLCγ1 and Akt, which was increased upon AngII or PDGF stimulation. Depletion of PLCγ1 by siRNA significantly inhibited Akt and Notch1 activation. As the major target gene of Notch1, Hey2 protein expression was increased 1.8 fold and 2.3 fold respectively after AngII and PDGF stimulation. PLCγ1 siRNA treatment inhibited it by 68.3% and 64.7%. Depletion of PLCγ1 significantly inhibited PDGF induced VSMC proliferation, migration and dedifferentiation but increased apoptosis. In vivo, PLCγ1 and control siRNA were delivered periadventitially in pluronic gel after carotid ligation. Morphometric analysis 21days after ligation demonstrated that PLCγ1 depletion attenuated intima area (2.2 ± 0.7 vs 4.3 ± 1.0, *104 μm2) and intima/media ratio (0.21 ± 0.09 vs 0.43 ± 0.12) compared to the control group. Conclusions: In conclusion, PLCγ1 mediated Akt-Notch1 signaling is crucial for intima formation. The PLCγ1 and Akt interaction will be a promising target for therapeutic stratergies that inhibit vascular remodeling.
Measurement of Myocardial Blood Flow With Positron Emission Tomography Before and After Transmyocardial Laser Revascularization
Authors: O Rimoldi, S M Burns, S D Rosen, T E Wistow, P M Schofield, G Taylor, P G Camici
Journal: Circulation (1999)

Transmyocardial laser revascularization (TMLR) has been proposed for treatment of refractory angina. It has been hypothesized that transmural left ventricular channels created by laser improve myocardial blood flow (MBF) in the treated zones. We aimed to assess the effect of TMLR on MBF and coronary vasodilator reserve (CVR).We measured MBF by means of PET with (15)O-labeled water in 7 patients with refractory angina, Canadian Cardiovascular Society (CCS) class 3.6+/-0.5, on 3 occasions: before and at 7.5+/-2.8 weeks (FU-1) and 34.6+/-4.7 weeks (FU-2) after TMLR performed with a synchronized, high-powered CO(2) laser. In each study, MBF was measured at rest and during maximal intravenous dobutamine. CVR was computed as dobutamine divided by resting MBF. After TMLR, CCS class was 2.2+/-1.7 at FU-1 and 2.4+/-1 at FU-2 (P=0.04 versus pre-TMLR). Resting MBF in both lasered and nonlasered regions was unchanged after TMLR. Dobutamine MBF at baseline was 1.45+/-0.52 and 1.55+/-0.52 mL. min(-1). g(-1) in lasered and nonlasered regions, respectively (P=NS). At FU-1, dobutamine MBF in nonlasered regions had increased significantly to 1.89+/-0.82 mL x min(-1) x g(-1) (P<0.05) and was higher than in lasered regions (1.51+/-0.61 mL x min(-1) x g(-1); P<0.05 versus nonlasered). At FU-2, dobutamine MBF in nonlasered regions was still higher than in lasered regions (1.56+/-0.54 versus 1.21+/-0.44 mL x min(-1) x g(-1); P<0.01). CVR was comparable in nonlasered and lasered regions at baseline and FU-1, whereas it was higher in nonlasered regions at FU-2 (1.86+/-0.67 versus 1.53+/-0.72 mL x min(-1) x g(-1); P<0.05).TMLR has been shown to reduce angina in severely diseased patients. The results of our study do not support the hypothesis that the symptomatic benefit of TMLR can be ascribed to improved myocardial perfusion or CVR in lasered areas.
CHLORAMPHENICOL (CHLOROMYCETIN®) AND AUREOMYCIN
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Error in Figure Label and Caption
Authors: Kadri Altundag
Journal: JAMA Oncology (2018)

Joanne Kotsopoulos, PhD; Jacek Gronwald; Beth Y. Karlan, MD; Tomasz Huzarski, MD; Nadine Tung, MD; Pal Moller, MD; Susan Armel; Henry T. Lynch, MD; Leigha Senter; Andrea Eisen, MD; Christian F. Singer, MD, MPH; William D. Foulkes, MBBS, PhD; Michelle R. Jacobson, MD, MHSc; Ping Sun, PhD; Jan Lubinski; Steven A. Narod, MD; for the Hereditary Breast Cancer Clinical Study Group
Number Concentration and Size of Particles in Urban Air: Effects on Spirometric Lung Function in Adult Asthmatic Subjects
Authors: Pasi Penttinen, Kirsi Liisa Timonen, Pekka Tiittanen, Aadu Mirme, Juhani Ruuskanen, Juha Pekkanen
Journal: Environmental Health Perspectives (2001)

Daily variations in ambient particulate air pollution are associated with variations in respiratory lung function. It has been suggested that the effects of particulate matter may be due to particles in the ultrafine (0.01-0.1 microm) size range. Because previous studies on ultrafine particles only used self-monitored peak expiratory flow rate (PEFR), we assessed the associations between particle mass and number concentrations in several size ranges measured at a central site and measured (biweekly) spirometric lung function among a group of 54 adult asthmatics (n = 495 measurements). We also compared results to daily morning, afternoon, and evening PEFR measurements done at home (n = 7,672-8,110 measurements). The median (maximum) 24 hr number concentrations were 14,500/cm(3) (46,500/cm(3)) ultrafine particles and 800/cm(3) (2,800/cm(3)) accumulation mode (0.1-1 microm) particles. The median (maximum) mass concentration of PM(2.5) (particulate matter < 2.5 microm) and PM(10) (particulate matter < 10 microm in aerodynamic diameter) were 8.4 microg/m(3) (38.3 microg/m(3)) and 13.5 microg/m(3) (73.7 microg/m(3)), respectively. The number of accumulation mode particles was consistently inversely associated with PEFR in spirometry. Inverse, but nonsignificant, associations were observed with ultrafine particles, and no associations were observed with large particles (PM(10)). Compared to the effect estimates for self-monitored PEFR, the effect estimates for spirometric PEFR tended to be larger. The standard errors were also larger, probably due to the lower number of spirometric measurements. The present results support the need to monitor the particle number and size distributions in urban air in addition to mass.
Decree of Nullity of Marriage Obtained by Blood Test
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
JAMA Dermatology
Journal: JAMA Dermatology (2018)

Mission Statement JAMA Dermatology publishes information concerning the skin, its diseases, and their treatment.Its mission is to explicate the structure and function of the skin and its diseases and the art of using this information to deliver optimal medical and surgical care to the patient.We attempt to enhance the understanding of cutaneous pathophysiology and improve the clinician's ability to diagnose and treat skin disorders.This journal has a particular interest in publishing clinical and laboratory studies that reveal new information pertinent to the interests and needs of the medical dermatologist, dermatologic surgeon, and all those concerned with state-of-the-art care of cutaneous disease.We believe that knowledge derived from well-designed clinical trials and studies of cost-eff ectiveness are especially important for improving the practice of dermatology.Studies that increase the understanding of the outcome of treatment or the means by which the burden of dermatologic disease can be measured and reduced to promote the health of patients with skin disease will receive special priority.The journal regularly publishes reports on clinical investigations, editorials, and reviews.It also features reports and discussions on clinicopathologic correlations; clinical disorders of unique didactic value; pharmacologic, medical and surgical therapeutics; and ethical, moral, socioeconomic, and political issues.
Preoperative chemoradiotherapy and postoperative chemotherapy with 5-fluorouracil and oxaliplatin versus 5-fluorouracil alone in locally advanced rectal cancer: First results of the German CAO/ARO/AIO-04 randomized phase III trial.
Authors: C. Roedel, H. Becker, R. Fietkau, U. Graeven, W. Hohenberger, T. Hothorn, M. Lang-Welzenbach, T. Liersch, L. Staib, H. Christiansen, C. Wittekind, R. Sauer
Journal: Journal of Clinical Oncology (2011)

LBA3505 The full, final text of this abstract will be available in Part II of the 2011 Annual Meeting Proceedings, distributed onsite at the Meeting on June 4, 2011, and as a supplement to the June 20, 2011, issue of Journal of Clinical Oncology.
Abstract 27: Elevated Soluble Interleukin 2 Is A Risk Of Treatment Resistance And Coronary Artery Abnormalities In Kawasaki Disease
Authors: Shinichi Takatsuki, Junko Takebe, Kazuyuki Naoi, Satoshi Ikahara, Tomotaka Nakayama, Hiroyuki Matsuura, Toshisuke Morita, Tsutomu Saji
Journal: Circulation (2015)

Background and objective: Soluble ST2 (sST2), an interleukin (IL)-1 receptor family member, has been identified as a novel biomarker for cardiac stress. Although sST2 were reported to be elevated in acute Kawasaki disease (KD) and correlated with cardiac diastolic dysfunction, relation between sST2 levels and treatment resistance and risk of coronary artery abnormalities (CAAs) is not studied. The aim of this study is to evaluate clinical utility of sST2 in acute KD. Methods: We measured serum sST2 from 54 children (median age; 22 months, 29 boys and 26 girls) with acute KD before and after initial treatment, 10 febrile controls (FC) (median age; 14 months) and 2 healthy controls (HC). Using Kobayashi score from RAISE study, patients were divided into high (&gt;score 5)and low risk group (≤score 4) for IVIG resistance. Results: Serum sST2 in KD significantly elevated compared with FC and HC (median; KD vs FC 0.81 vs 0.25 ng/ml, p&lt;0.05, KD vs HC 0.81 vs 0.12 ng/ml, respectively, p&lt;0.05). Compared with sST2 levels before treatment, sST2 decreased at 4 days after initial therapy, but it was not significant (median 0.81 vs 0.67 ng/ml). Statistically significant differences were observed in sST2 between high risk group and low risk group (median; 1.80 vs 0.54 ng/ml, respectively, p&lt;0.05). Additionally, sST2 levels in non-responders to initial treatment were significantly higher than those in responders (median; 1.65 vs 0.64 ng/ml, respectively, p&lt;0.05). There were no significant correlations between sST2 level at diagnosis and plasma brain natriuretic peptide (r = -0.05), C-reactive protein (r = 0.04), and AST (r = 0.07). Overall, 4 children (7%) had CAAs at 4 weeks of illness. sST2 levels at diagnosis were not significantly different between children with and without CAAs, median sST2 levels in children without CAAs (1.68 vs 0.79 ng/ml, respectively, p=0.07). At 4 days after initial therapy, median sST2 levels decreased in children without CAAs, (0.79 vs 0.65, p=0.1), whereas median sST2 levels increased in children with CAAs (1.68 vs 1.70, p=0.9). Conclusions: Elevated sST2 may be a potential risk factor of initial treatment resistance and developing CAAs in acute KD.
Current Tobacco, Alcohol, Marijuana, Cocaine Use
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Clinical Lecture on a Third Series of Cases of Total Extirpation of the Prostate for Radical Cure of Enlargement of that Organ: Delivered at the Medical Graduates' College and Polyclinic
Authors: P. J. Freyer
Journal: BMJ (1902)

had. to get up and go to the sick ward, as pain came on acutely with swelling, and he vomited.The second case occurred in a lad of 20, who gave no history of injury.Clinically the case presented the same course as the former, and the result was extreme atrophy of the testis.
Abstract 4429: Delivery of miR-143 and miR-506 with novel nano carrier to arrest cell cycle in lung cancer
Authors: A K M Nawshad Hossian, Chandra Mohan Reddy Muthumula, George Mattheolabakis
Journal: Cancer Research (2019)

Abstract Lung cancer is the leading cause of cancer related deaths worldwide. Although targeting the cell cycle of cancer cells has been a promising approach, no such therapy has translated for the treatment of lung cancer. In our previous work, we identified that the combinatorial treatment of two miRNAs, miR-143 and miR-506, inhibited the cell cycle of lung cancer cells in vitro. These miRs downregulated the CDK1 and CDK4/6 genes, which are involved in the G1/S and G2/M transitions, respectively. Nucleic acid delivery has met formidable challenges, such as short in vivo half-life and rapid degradation in the circulation, as well as limited cell penetration or endosomal escape. We developed a novel nanocarrier, composed of tocopherol (vitamin E), polyethylenenimine, and polyethylene glycol (TPP) in 1:1:1 molar ratio for the delivery of miRNAs. Proper characterization with NMR and FTIR confirmed the synthesis of this molecule. We found it can form nanomicelles, and the positively charged of polyethyleneimine allowed for the complexation of miRNAs, as was detected by a gel retardation assay. Fluorescently tagged TPP micelles were uptaken by cancer cells, and the carrier successfully transfected cancer cells with the combinatorial miRNA treatment inducing gene downregulation. In vivo pharmacokinetics study using a subcutaneous mouse model of lung cancer indicated prolonged accumulation of the TPP-miRNA micelles in the tumor area. In vivo administration of the miR-143/506 in TPP micelles, along with cisplatin co-treatment, inhibited tumor growth in a subcutaneous mouse model of lung cancer. Overall, the promising role of miR-143 and 506 for the regulation of LC growth may be achieved by this novel TPP-based nanocarrier, which merits further evaluation. Citation Format: A K M Nawshad Hossian, Chandra Mohan Reddy Muthumula, George Mattheolabakis. Delivery of miR-143 and miR-506 with novel nano carrier to arrest cell cycle in lung cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4429.
THE AMERICAN PHYSICIAN IN FACT AND IN FICTION
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Incorrect Table Title
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Asthma Prevalence and Mold Levels in US Northeastern Schools
Authors: Evin Howard, Stephen Vesper, Barbara Gunthrie, Carter Petty, Valeria Ramden, Will Sheehan, Jonathan Gaffin, Perdita Permaul, Peggy Lai, Lisa Bartnikas, Amparito Cunningham, Marissa Hauptman, Diane Gold, Sachin Baxi, Wanda Phipatanakul
Journal: Journal of Allergy and Clinical Immunology (2021)