tbuckley/cabot-search huggingface dataset:
Spontaneous Hyphema and Acute Glaucoma as Initial Signs of Recurrent Iris Melanoma
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Two Rooms
Authors: Elisha Waldman
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Incorrect Unit in Laboratory Value
Authors: Falk Leichsenring, Christiane Steinert
Journal: JAMA (2018)

US Preventive Services Task Force; Kirsten Bibbins-Domingo, PhD, MD, MAS; David C. Grossman, MD, MPH; Susan J. Curry, PhD; Michael J. Barry, MD; Karina W. Davidson, PhD, MASc; Chyke A. Doubeni, MD, MPH; John W. Epling Jr, MD, MSEd; Alex R. Kemper, MD, MPH, MS; Alex H. Krist, MD, MPH; Ann E. Kurth, PhD, RN, MSN, MPH; C. Seth Landefeld, MD; Carol M. Mangione, MD, MSPH; William R. Phillips, MD, MPH; Maureen G. Phipps, MD, MPH; Michael Silverstein, MD, MPH; Melissa A. Simon, MD, MPH; Chien-Wen Tseng, MD, MPH, MSEE
A multicenter phase II study of sequential paclitaxel and S-1 (TXL/S-1) as postoperative adjuvant chemotherapy for gastric cancer (GC)
Authors: N. Nagata, A. Tsuburaya, M. Kimura, Y. Emi, N. Hirabayashi, M. Kobayashi, H. Itoh, J. Sakamoto
Journal: Journal of Clinical Oncology (2005)

4067 Background: Of patients who undergo R0 resection for GC with serosal invasion (T3–4), more than half recur mainly in the peritoneum (and eventually need palliative chemotherapy). So far compliance of early postoperative chemotherapy was low and it has failed to suppress peritoneal relapse. Since TXL and S1 exhibited efficacy for diffuse type and peritoneal tumors in the phase II studies, we have investigated the safety and feasibility of TXL/S1 as sequential adjuvant chemotherapy following radical resection of T3–4 gastric cancer. Methods: Eligibility criteria included histologically proven GC; sT3–4; sN0–2; M0 (except peritoneal cytology); post D2–3 gastrectomy and R0–1; ECOG PS 0–1; and 20–80 years old. On postoperative day 14 to 56, patients received 3 courses of weekly TXL (80mg/m2 on day 1, 8 for the 1st course and on day 1, 8, 15 for the 2nd and 3rd courses, repeated every 3 or 4 weeks) followed by 4 courses of S1 (80mg/m2 daily for 2 weeks, repeated every 3 weeks). The primary endpoints were % of patients who completed all 7 courses (compliance) and incidence of severe toxicities and the secondary endpoints were survival and toxicities. Primary analysis was to see whether the lower 95% confidence limit of compliance was greater than 69% and sample size of 50 was calculated. Results: 50 patients were accrued from May 2003 to March 2004. The median age was 63 (range 33–74); male/female: 34/16; pT2/T3/T4: 2/41/4; f-stage2/3a/3b/4: 11/13/16/7. In 4 patients treatment was terminated for toxicities, in 2 for refusal, and in one for recurrence; thus compliance of 87.9% (95%CI:81–98%) was achieved. Grade 4 hematological toxicities in 2% and grade 3 non-hematological toxicities in 4% of the patients were observed. The analysis for survival will be performed in 2007. Conclusions: Sequential chemotherapy with TXL/S1 was safe and well tolerated as a postoperative adjuvant treatment for patients with T3 tumors. Its survival benefit will be assessed in a large phase III study (the SAMIT trial). No significant financial relationships to disclose.
Differential and Limited Expression of Mutant Alleles in Multiple Myeloma
Authors: Adam Sperling, Naim Rashid, Niccolo Bolli, David Wedge, Peter Van Loo, Yu-Tzu Tai, Masood Shammas, Mariateresa Fulciniti, Mehmet Kemal Samur, Paul G. Richardson, Florence Magrangeas, Stephane Minvielle, P Andrew Futreal, Kenneth C. Anderson, Herve Avet-loiseau, Peter J. Campbell, Giovanni Parmigiani, Nikhil Munshi
Journal: Blood (2014)
Emergency contraception.
Authors: P. J M Davis
Journal: BMJ (1991)

this hospital and in other hospitals) performed significantly better (p<005) in the practical test than those who had had less than regular training.In addition, the house officers performed signifi- cantly better (p<002) than the senior house officers.The Royal College of Physicians has recom- mended an improvement in training in cardiopulmonary resuscitation and assessment of skills at both undergraduate and postgraduate levels.'Only a third of this study group had been questioned on cardiopulmonary resuscitation in a formal examination; none had ever been asked to demonstrate their practical skills.The Royal College of General Practitioners is the only royal college that requires examination candidates to be competent in cardiopulmonary resuscitation; perhaps other colleges ought to change their requirements.Surveys continue to highlight the inadequacies of training in cardiopulmonary resuscitation for junior doctors,6 and it is reasonable to assume that these shortcomings will extend throughout the medical hierarchy as time goes by.There is a need for regular training in cardiopulmonary resuscita- tion and more formal testing of skills both in medical examinations and in the workplace.At present the situation falls far short of the ideal.
A PATHOLOGICAL INQUIRY INTO THE EFFECTS OF SYPHILIS UPON THE UTERINE ORGANS
Authors: F. W. Mackenzie
Journal: BMJ (1854)

WWw &*S* I now add to eh eparate quantity of ipecac wie or other vehicle, the exact number of drops of chloro form necwy for the dose, and thus avoid the uncertainty which must attend a careless or imperfect mixture of the ingredients.Chloroform possesses one great advantage over most medicines; children do not dislike its taste, and properly mixed, they will take it readily.In some cases of hysterical spasmodic cough, seen by Dr.Andrew Wood, and reported to the Medico-Chimrgical So- ciety of Edinburgh in March last, he administered chloro- form with success; I am not sufficiently satisfied of the dis- tinctive character of hooping cough to think that a remedy successful in the one case might not be so in the other.Considering uncomplicated hooping cougrh to partake more of a spasmodic than of any other nature, I hold the general indications of treatment to be:To relieve or prevent the spasmodic paroxysms: this will be most effectually done by the internal use of chlo- roform.To remove any obstruction collecting in the air passages by the use of occasional emetics, of which ipecacuan wine is the best.To support the system under the weakening effects of the disease.
Multiple Mechanisms for the Carcinogenic Effects of Asbestos and Other Mineral Fibers
Authors: J. Carl Barrett, Patricia W. Lamb, Roger W. Wiseman
Journal: Environmental Health Perspectives (1989)

Asbestos and other mineral fibers are carcinogenic to humans and animals but differ from many carcinogens in that they do not induce gene mutations. An understanding of these interesting human carcinogens, therefore, is an important problem in cancer research. Asbestos and other fibers induce predominantly two types of cancers: mesotheliomas and bronchogenic carcinomas. Fiber size is an important factor in the carcinogenic activity of these substances as has been shown for mesothelioma induction. For bronchogenic carcinomas, but not for mesotheliomas, a synergistic effect of asbestos exposure and cigarette smoke has been observed in humans. The mechanisms by which fibers alone versus fibers in concert with other carcinogens induce cancers are probably distinct. In addition to fiber dimensions, fiber durability and surface properties of fibers are important properties affecting carcinogenicity. Evidence exists that asbestos is a complete carcinogen, an initiator and a promoter. Multiple mechanisms must be operative to explain the diverse effects of mineral fibers. Although asbestos is inactive as a gene mutagen, there is now clear evidence that it induces chromosomal mutations (aneuploidy and aberrations) in a wide variety of mammalian cells including mesothelial cells. Asbestos also induces transformation of cells in culture including mesothelial cells and fibroblasts. A mechanism for cell transformation, which is dependent on fiber dimension, has been proposed. The fibers are phagocytized by the cells and accumulate in the perinuclear region of the cells. When the cell undergoes mitosis, the physical presence of the fibers interferes with chromosome segregation and results in anaphase abnormalities. The transformed cells show aneuploidy and other chromosome abnormalities.(ABSTRACT TRUNCATED AT 250 WORDS)
Natural leukocyte interferon‐α therapy in patients with chronic granulocytic leukemia who have antibody‐mediated resistance to treatment with recombinant interferon‐α
Authors: Ayalew Tefferi, Darryl C. Grendahl
Journal: American Journal of Hematology (1996)

Two patients with chronic-phase chronic granulocytic leukemia initially responded to recombinant interferon α-2a (rIFN-α-2a) but relapsed as a result of development of high-titer neutralizing antibodies to rIFN-α-2a. Both patients were subsequently treated with natural leukocyte IFN-α (IFN-α-n3), and one of the two patients achieved a durable second hematologic and cytogenetic remission. IFN-α-n3 may be considered for patients in whom antibody-mediated resistance to rIFN-α-2a develops. © 1996 Wiley-Liss, Inc.
Das dextrocardias: Subsidio ao seu estudo clinico e electro-cardiographico.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Gene Therapy
Authors: J. L. Mehta
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Absence of Association or Genetic Linkage between the Angiotensin-Converting–Enzyme Gene and Left Ventricular Mass
Authors: Klaus Lindpaintner, MinAe Lee, Martin G. Larson, V. Srinivas Rao, Marc A. Pfeffer, Jose M. Ordovas, Ernst J. Schaefer, Alexander F. Wilson, Peter W.F. Wilson, Ramachandran S. Vasan, Richard H. Myers, Daniel Levy
Journal: New England Journal of Medicine (1996)

Homozygous carriers of the D allele of the angiotensin-converting–enzyme (ACE) gene have been reported to be at increased risk for various cardiovascular disorders, including left ventricular hypertrophy. We investigated the potential role of the ACE gene in influencing left ventricular mass.
The number and distribution of hepatic natural killer cells (pit cells) in normal rat liver: An immunohistochemical study
Authors: Dianzhong Luo, Karin Vanderkerken, Luc Bouwens, Peter J. K. Kuppen, Evelyne Crabbé, Eddie Wisse
Journal: Hepatology (1995)

Pit cells are a unique population of cells in sinusoids and peripheral blood, which can be considered natural killer (NK) cells with large granular lymphocyte (LGL) morphology. The aim of this study was to investigate the use of the monoclonal antibody (MAb) 3.2.3 as a specific marker of rat pit cells to detect their number and distribution in the liver. The number of 3.2.3-positive cells was comparable to the number of LGL in liver low-density (LD) and high-density (HD) pit cell fractions and in blood lymphocytes ( P &gt; 0.05). Immunoelectron microscopy showed that nearly all LGL in hepatic LD and HD and in blood fractions were 3.2.3 positive. Using MAb 3.2.3 immunoperoxidase staining, the mean number of pit cells in liver frozen sections was determined to be 13.7 ± 1.1/mm 2 . The number of pit cells was similar in the different liver lobes ( P &gt; 0.05). Reduced nicotinamide-adenine dinucleotide (NADH) oxidase histochemical staining, to visualize a portal to central vein gradient, combined with immunostaining was used to analyze the lobular distribution of pit cells. We found that 61.3% (17.1/mm 2 ) of pit cells were in the periportal area and 38.7% (10.8/mm 2 ) in the central area. We conclude that MAb 3.2.3 can be used as a specific marker of rat pit cells and therefore can be used to quantify rat pit cell number in various experimental models.
THE ATLANTIC CITY SESSION.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SOCIETY PROCEEDINGS.
Journal: JAMA (1889)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Book review
Authors: Andres T. Blei
Journal: Hepatology (1998)

Ammonia continues to be inexorably linked to the pathogenesis of hepatic encephalopathy.Dissection of its ability to affect multiple neurochemical pathways in the brain is the research challenge.The complexity of the relationship between ammonia and hepatic encephalopathy was analyzed at an International Symposium held in Valencia on December 1996, which was organized by a Spanish research group interested in metabolic encephalopathies.A full discussion of 17 presentations forms the basis of this volume.As is usually the case with such multiauthored volumes, the extent and quality of discussions are variable.Nonetheless, different insights into the pathogenesis of hepatic encephalopathy are presented, and hepatologists who have followed the controversy on mechanisms of neurotoxicity in liver disease should enjoy this focused neurochemical update.Abnormalities in neurotransmission are at the core of the disturbance of mental state and much work has been done in animal models to dissect their relative importance.The role of serotoninergic (Bengtsson, Lund) and glutamatergic (Butterworth, Montreal) abnormalities in chronic liver disease and acute liver failure are discussed, as well as in the case of the glutamate and cholinergic systems that are linked to ammonia itself (Felipo, Valencia).The alteration of
Magnetic resonance 'sees' lesions of multiple sclerosis
Authors: T. Ziporyn
Journal: JAMA (1985)

The ability of magnetic resonance imaging (MRI) to distinguish white matter from gray and to define demyelinative lesions led to predictions, only a little over a year ago in the<i>Annals of Neurology</i>(1983; 13:592-600), of a promising future for this technique in diagnosing multiple sclerosis as well as in evaluating disease progression and response to treatment. Now, at the University of British Columbia (UBC), Vancouver, some of these predictions are becoming realities. "We got our foot in the door early," says Donald W. Paty, MD, head of the Division of Neurology at UBC, explaining the major commitment of his university and the Medical Research Council of Canada to MRI imaging (once called nuclear magnetic resonance or NMR) for multiple sclerosis research in particular. The need for extensive MRI research on multiple sclerosis is there. As Michael Brant-Zawadzki, MD (<i>JAMA</i>[MEDICAL NEWS] 1983;249:857-867), associate professor of radiology at the University
Government Services
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SOME CURRENT TENDENCIES IN VITAMIN RESEARCH
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal