tbuckley/cabot-search huggingface dataset:
Month of birth may be linked to risk of developing Crohn's disease
Journal: BMJ (2001)

Thyroxine does not benefit euthyroid people with symptoms of hypothyroidism Thyroxine is no more effective than placebo in improving cognitive function and psychological wellbeing in patients with symptoms of hypothyroidism but with thyroid function tests within the normal range.In addition, thyroxine does not improve cognitive function and psychological wellbeing in healthy adults.Pollock and colleagues (p 891) conducted a randomised, double blind, placebo crossover trial on 22 patients with symptoms of hypothyroidism, but biochemically euthyroid, and 19 healthy controls.They also found that there was no significant changes in clinical measurements such as blood pressure, pulse rate, or weight during the study. Metered dose inhalers are most cost effective for asthma drugsPressurised metered dose inhalers are the most cost effective method for delivering 2 agonists and corticosteroids in patients with stable asthma.In two systematic reviews (pp 896 and 901), the National Health Technology Assessment Inhaler Review Group found no significant differences between pressurised metered dose inhalers and other inhaler devices.These included dry powder inhalers, breath actuated devices, and hydrofluoroalkane devices.Use of a spacer device did not affect the results.Since pressurised metered dose inhalers are usually the cheapest form of treatment, they should be used as first line treatment unless there are specific contraindications.
Retraction Notice to: The Unfolded Protein Response Element IRE1α Senses Bacterial Proteins Invading the ER to Activate RIG-I and Innate Immune Signaling
Authors: Jin A. Cho, Ann-Hwee Lee, Barbara Platzer, Benedict C.S. Cross, Brooke M. Gardner, Heidi De Luca, Phi Luong, Heather P. Harding, Laurie H. Glimcher, Peter Walter, Edda Fiebiger, David Ron, Jonathan C. Kagan, Wayne I. Lencer
Journal: Cell Host & Microbe (2018)
You wrote it; you own it!
Authors: Emma Hill, Mike Rossner
Journal: The Journal of Experimental Medicine (2008)

Authors of papers published in Rockefeller University Press journals (The Journal of Cell Biology, The Journal of Experimental Medicine, or The Journal of General Physiology) now retain copyright to their published work. This permits authors to reuse their own work in any way, as long as they attribute it to the original publication. Third parties may use our published materials under a Creative Commons license, six months after publication.
THE FUNCTION OF THE SPLEEN IN THE EXPERIMENTAL INFECTION OF ALBINO MICE WITH BACILLUS TUBERCULOSIS
Authors: Paul A. Lewis, Arthur Georges Margot
Journal: The Journal of Experimental Medicine (1915)

Experiments are reported which show that in all probability the increased resistance to tuberculous infection which is imparted to mice by the removal of the spleen is a consequence of the loss of a function of the organ. This function can be restored by the feeding of fresh spleen. For the present we attribute these changes to the removal and restoration, as the case may be, of a particular substance for which the designation tuberculosplenatin is suggested. This substance is assumed to be related to the spleen as adrenalin is related to the adrenal gland. It is peculiar to the organ but not to the species. It is not found in other organs of the body so far as our observations have extended. The absence of the substance from the lymphatic glands seems of especial importance in this connection.
A COUNTY BACTERIOLOGIST.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Randomized Trial of Lenalidomide Plus High-Dose Dexamethasone (RD) Versus Lenalidomide Plus Low-Dose Dexamethasone (Rd) in Newly Diagnosed Multiple Myeloma (E4A03): A Trial Coordinated by the Eastern Cooperative Oncology Group.
Authors: S. Vincent Rajkumar, Susanna Jacobus, Natalie Callander, Rafael Fonseca, David Vesole, Michael Williams, Rafat Abonour, David Siegel, Philip Greipp
Journal: Blood (2007)
Copy Number Alterations that Predict Metastatic Capability of Human Breast Cancer
Authors: Yi Zhang, John W.M. Martens, Jack X. Yu, John Jiang, Anieta M. Sieuwerts, Marcel Smid, Jan G.M. Klijn, Yixin Wang, John A. Foekens
Journal: Cancer Research (2009)

We have analyzed the DNA copy numbers for over 100,000 single-nucleotide polymorphism loci across the human genome in genomic DNA from 313 lymph node-negative primary breast tumors for which genome-wide gene expression data were also available. Combining these two data sets allowed us to identify the genomic loci and their mapped genes, having high correlation with distant metastasis. An estimation of the likely response based on published predictive signatures was performed in the identified prognostic subgroups defined by gene expression and DNA copy number data. In the training set of 200 patients, we constructed an 81-gene prognostic copy number signature (CNS) that identified a subgroup of patients with increased probability of distant metastasis in the independent validation set of 113 patients [hazard ratio (HR), 2.8; 95% confidence interval (95% CI), 1.4-5.6] and in an external data set of 116 patients (HR, 3.7; 95% CI, 1.3-10.6). These high-risk patients constituted a subset of the high-risk patients predicted by our previously established 76-gene gene expression signature (GES). This very poor prognostic group identified by CNS and GES was putatively more resistant to preoperative paclitaxel and 5-fluorouracil-doxorubicin-cyclophosphamide combination chemotherapy (P = 0.0048), particularly against the doxorubicin compound, while potentially benefiting from etoposide. Our study shows the feasibility of using copy number alterations to predict patient prognostic outcome. When combined with gene expression-based signatures for prognosis, the CNS refines risk classification and can help identify those breast cancer patients who have a significantly worse outlook in prognosis and a potential differential response to chemotherapeutic drugs.
Cat-Scratch Disease
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Biopsy of occult breast lesions. Analysis of 1261 abnormalities
Authors: J. E. Meyer
Journal: JAMA (1990)

From January 1, 1987, to December 31, 1988, roentgenographically guided biopsies of 1261 occult breast abnormalities were performed. There were 626 (49.6%) masses and 635 (50.4%) lesions with calcification as the dominant feature. Of the total, 237 (18.8%) were found to be malignant, including 85 cases of ductal carcinoma in situ. Biopsies performed for a mass yielded a 20.8% (130/626) incidence of cancer; and for calcification, 16.9% (107/635). The biopsy results were supported by the interpretations of four radiologists (J.E.M., P.C.S., and M.R.S.) who were practicing at Brigham and Women's Hospital in 22.2% of the total (280), whereas the remaining 981 lesions were discovered on mammograms that were performed and interpretated elsewhere and were referred to our hospital for surgical consultation. The biopsy results of the mammograms from other facilities yielded a positive predictive value of 16.7% (164/981) vs 26.1% (73/280) for the Brigham and Women's Hospital group. This statistically significant difference lends support to the value of a second opinion in patients with biopsy recommendations for occult breast lesions, especially when findings are inconclusive. (<i>JAMA</i>. 1990;263:2341-2343)
CLIN-EPIDEMIOLOGY
Authors: R. B. Khan, M. M. Hudson, E. Brannon Morris, D. Ledet, C.-H. Pui, H. Scott, E. Browne, D. Crom, P. Hinds, L. Zhu, S. Kumar, K. K. Ness, L. R. Rogers, Q. Ostrom, J. Vengoechea, Y. Chen, P. Davitkov, K. Strodtbeck, W. R. Selman, S. Gerson, C. Nock, M. Machtay, S. Lo, A. E. Sloan, J. Barnholtz-Sloan, D. R. Johnson, P. A. Decker, A. C. Hanson, J. E. Hammack, E. S. Amirian, J. C. Goodman, P. New, M. E. Scheurer, C. Kruchko, T. A. Dolecek, B. J. McCarthy, B. H. Mulpur, L. B. Nabors, K. M. Egan, J. E. Browning, J. J. Olson, R. C. Thompson, M. H. Madden, P. J. Lupo, Y. Cai, D. Nousome, M. E. Scheurer, B. P. O'Neill, P. A. Decker, J. R. Cerhan, J. L. Villano, V. Moirangthem, T. Pittman, E. B. Durbin, C. J. Campen, J. Von Behren, P. Reynolds, P. G. Fisher, V. L. Merker, W. H. Slattery, A. Muzikansky, F. G. Barker, S. R. Plotkin, L. E. Rotman, Q. Ostrom, J. Vengoechea, B. Kuhns, L. Rogers, A. Sloan, J. Barnholtz-Sloan, M. M. Mrugala, P. Y. Wen, L. R. Rogers, A. M. Sonabend, B. E. Zacharia, H. Goldstein, S. Bruce, J. N. Bruce, T. Kim, V. L. Chiang, J. B. Yu
Journal: Neuro-Oncology (2012)
Corrigendum
Journal: Behavioral and Brain Sciences (1994)

On p. 611 of Continuing Commentary by Martin Davis [ BBS 16(3) 1993] on Roger Penrose's “Précis of The emperor's new mind: Concerning computers, minds, and the laws of physics” [BBS 13(4) 1990] the author neglected to note that the quotation from Gödel in the cited book by Rudy Rucker had originally been obtained by Rucker from Hao Wang's (1974) From mathematics to philosophy , Routledge &amp; Kegan Paul; Humanities Press, p. 324.
Sickle cell anemia and hyperuricemia
Authors: M. S. Gold
Journal: JAMA (1968)

Sickle cell anemia, hyperuricemia, and gout occurred in a 53-year-old woman. The hyperuricemia is felt to be the result of the increased erythropoiesis of sickle cell disease. This concept is supported by the finding of a significant incidence of hyperuricemia in other patients with sickle hemoglobinopathies.
Multiple pathways for estrone sulfate uptake in isolated rat hepatocytes . Faculty of Pharmacy# and Department of Pharmacology*, University of Toronto, Canada
Journal: Hepatology (1995)

A common neurologic disorder occurring in patients with AIDS is a progressive dementia, referred to as AIDS dementia complex, characterized by increasingly severe cognitive, behavioral and motor impairment. The progression of this disorder is associated with the presence and replication of HIV in the central nervous system (CNS). Many of the dideoxynucleosides effective in the treatment of HIV infections are quite polar molecules and exhibit limited penetration into the CNS. Studies in our laboratories in rats have shown that the steady-state concentration of 2',3'-dideoxyinosine (ddI) in the cerebrospinal fluid is less than 2% of the simultaneously determined plasma concentration, indicating that approaches to increase the CNS uptake of ddI and other dideoxynucleosides are needed. A compartmental model has been developed to describe the pharmacokinetics and CNS uptake of ddI and to simulate various approaches for increased delivery of ddI to the CNS. Two general approaches considered are inhibition of the rate of efflux from the cerebrospinal fluid by coadministration of active transport inhibitors and enhancement of the rate of entry into the CNS through chemical modification (prodrugs). Model simulations suggested that increases in steady-state concentrations of ddl in cerebrospinal fluid of ≈ 5-fold could be achieved by inhibiting the rate of efflux. Coadministration of the active transport inhibitor probenecid was shown to increase ddI concentrations in cerebrospinal fluid by 5.4-fold. Much larger increases in delivery of ddI to the CNS are possible via the prodrug approach, according to model calculations, but a number of variables, including lipophilicity, bioconversion t12 in brain tissue, and systemic bioconversion t12, must be optimized to achieve these increases. A series of 5'-esters of ddl were shown to provide little, if any, advantage in CNS delivery due to their high ratios of bioconversion rates in plasma relative to brain tissue. A series of 6-halo-dideoxypurines, which are activated by adenosine deaminase, have been shown to undergo more rapid bioconversion to the parent drug in brain tissue than in blood. Thirty minute infusions of 6-Cl-ddP in rats resulted in ddI concentrations in cerebrospinal fluid and brain parenchyma which were 5-fold and 24-fold higher, respectively, than when ddI was administered at the same infusion rate. Model calculations suggest that further increases are possible.
Cardiac Exercise Hemodynamics Late After Partial Left Ventriculectomy
Authors: Karen B. James, Garrie Haas, Suzanne R. Lutton, David Prior, Kathy Wolski, Tiffany Buda, Patrick M. McCarthy
Journal: Circulation (2000)

Background —Although some patients report favorable activity levels late after partial left ventriculectomy (PLV), their exercise physiology has not been well described. Methods and Results —We performed upright bicycle hemodynamics in 10 patients (9 men) aged 56±12 years at 1.7 years after PLV. Ejection fraction was 25±4%. Patients biked 10±7 minutes. With exercise, the mean pulmonary arterial pressure rose from 36±12 to 52±10 mm Hg ( P =0.0003). The mean pulmonary capillary wedge pressure rose from 25±14 to 36±9 mm Hg ( P =0.0566), and the cardiac index rose from 2.2±0.5 to 3.8±1.6 L · min −1 · m −2 ( P =0.0077). The mixed venous oxygenation with exercise declined from 44±9% to 24±17% ( P =0.0220), and the pulmonary vascular resistance increased from 2.0±0.9 to 2.3±1.1 Wood units ( P =0.5566). Conclusions —In late follow-up after PLV with exercise, the cardiac index is significantly augmented. However, there are further rises in pulmonary artery and pulmonary capillary wedge pressures, suggesting abnormal compliance, with marked decline in mixed venous oxygenation. Elucidating late physiology after PLV may help pave the way for future innovative heart failure surgeries.
CRYOGLOBULINEMIA
Authors: G. H.
Journal: JAMA (1960)

Farmer, Cooper, and Pascuzzi,<sup>1</sup>in an article currently appearing in the<i>Archives of Internal Medicine</i>, discuss disease states characterized by the presence of a cold-precipitable serum globulin. Wintrobe and Buell in 1933 observed in a 56-year-old patient with multiple myeloma that the serum formed a viscid layer when cooled to 4† C., and that a suspension of white material developed which dissolved when the serum was warmed to room temperature. This patient had a total serum protein of 11.9 Gm./100 ml. He had symptoms suggestive of Raynaud's disease, which it was thought were related to the concentration of abnormal globulin. The term "cryoglobulin," derived from the Greek "<i>kryos</i>" meaning cold, was given to this protein by Lerner and associates in 1947. They described a patient with cardiovascular renal disease and a cryoglobulin concentration of 800 mg./100 ml. serum who had purpura when exposed to cold. They believed the cryoglobulin
Council on Medical Education and Hospitals
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Relation of Micro-Organisms to Disease.
Journal: JAMA (1883)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sebocytes contribute to skin inflammation by promoting the differentiation of T helper 17 cells
Authors: M. Mattii, M. Lovászi, N. Garzorz, A. Atenhan, M. Quaranta, F. Lauffer, A. Konstantinow, M. Küpper, C.C. Zouboulis, L. Kemeny, K. Eyerich, C.B. Schmidt-Weber, D. Törőcsik, S. Eyerich
Journal: British Journal of Dermatology (2018)

The main function of cells in the skin called sebocytes is considered to be the production of lipids (oils) to moisturize the skin. It used to be thought that they were bystander cells during skin inflammation with no impact on the body's immune response, meaning they did not help the body to fight off signs of infection on inflammation. However, it recently became apparent that sebocytes do in fact respond to signs of inflammation (proinflammatory stimuli) as well as the presence of bacteria, and they release tiny protein molecules called chemokines and cytokines which play a role in inflammation. This discovery prompted scientists from Germany and Hungary to examine samples of skin with acne and skin without acne, to see if sebocytes also have any influence over white blood cells of the immune system (immune cells). The researchers found that sebocytes do indeed participate in inflammatory processes in the skin by recruiting and communicating with immune cells, and this interaction leads to the generation of Th17 cells. Further studies have to clarify whether this relationship between sebocytes and Th17 cells helps the immune system or, on the contrary, contributes to the development not only of acne, but also of several inflammatory skin diseases.
Finding Ping
Authors: Alexander C. McLeod
Journal: Annals of Internal Medicine (2003)

Letters7 October 2003Finding PingAlexander C. McLeod, MD, MBAAlexander C. McLeod, MD, MBAFrom Nashville, TN 37205-0451.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-139-7-200310070-00026-w1 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:This letter is written as a follow-up to an earlier essay (1). The encounter with Jiajia occurred in May 2001. When I returned to the United States in June, I initiated a search for her. In July, the U.S. Consulate General in Chengdu responded, providing the name of Jiajia's father and his address in a village near Chongqing. I sent him a letter, in English, with no real expectation of a reply. In November, a letter came from him, in Chinese, that included a photograph of Jiajia.A Chinese graduate student translated the letter, which stated that ...Reference1. McLeod AC. Finding Ping. Ann Intern Med. 2003;138:432-3. [PMID: 12614098] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Nashville, TN 37205-0451. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoFinding Ping Alexander C. McLeod Metrics 7 October 2003Volume 139, Issue 7Page: W-71KeywordsChildrenFeversForecastingGraduate medical educationInfectious diseasesLungsMemoryMotivationPneumonia ePublished: 7 October 2003 Issue Published: 7 October 2003 Copyright & PermissionsCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
THE EVOLUTION OF SPECIFIC THERAPY.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal