tbuckley/cabot-search huggingface dataset:
A phase II randomized trial of observation versus stereotactic ablative radiation for oligometastatic prostate cancer (ORIOLE).
Authors: Ryan Phillips, Noura Radwan, Ashley Ross, Steven P. Rowe, Michael A. Gorin, Emmanuel S. Antonarakis, Curtiland Deville, Stephen C Greco, Samuel R. Denmeade, Channing Judith Paller, Daniel Y. Song, Maximilian Diehn, Hao Wang, Michael Anthony Carducci, Kenneth J. Pienta, Martin G. Pomper, Theodore L. DeWeese, Adam P. Dicker, Mario A. Eisenberger, Phuoc T. Tran
Journal: Journal of Clinical Oncology (2017)

TPS5094 Background: ORIOLE is a randomized, non-blinded Phase II interventional study evaluating the safety and efficacy of SBRT in biochemically recurrent, oligometastatic, hormone-sensitive prostate cancer at 3 centers in the US. Patients will be stratified by clinical characteristics and randomized 2:1 to SBRT or observation. The primary clinical endpoint is progression at 6 months defined by PSA increase, radiologic or clinical evidence, ADT initiation, or death from any cause. Secondary endpoints include local control at 6 months, SBRT-associated toxicity and quality of life, and ADT-free survival. Imaging and laboratory correlates will characterize, in isolation, the effects of SBRT on oligometastatic disease. Methods: Eligible patients are hormone-sensitive, have undergone prior definitive treatment and recurred with 1-3 asymptomatic bone or soft tissue metastases diagnosed within 6 months, PSA doubling time (PSADT) &lt; 15 months, ECOG performance status ≤ 2, and normal organ and marrow function. Minimization will be used to balance assignment by primary intervention, prior ADT, and PSADT. Accrual of 54 patients provides 85% power to detect a decrease in progression rate from 80% to 40% with type I error = 0.05 using one-sided Fisher’s exact test. Hazard ratios and Kaplan-Meier estimates of progression free survival, ADT free survival, and time to locoregional and distant progression will be calculated based on intention-to-treat. Local control will be assessed using RECIST 1.1 criteria. Withdrawal prior to 6 months will be counted as progression. Adverse events will be summarized and quality of life pre- and post-SBRT will be measured by Brief Pain Inventory. The investigational targeted imaging agent 18 F-DCFPyL will be compared to bone scan and CT for identifying oligometastases before SBRT and monitoring disease response following SBRT. Biological alterations induced by SBRT will be investigated using circulating tumor cell analysis, deep sequencing of circulating tumor DNA, and T-cell repertoire profiling. A hereditary cancer assay will inform efforts to advance personalized screening and therapy. Clinical trial information: NCT02680587.
Respiratory Values
Journal: JAMA (1977)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Vpr R77Q is associated with long-term nonprogressive HIV infection and impaired induction of apoptosis
Authors: Julian J. Lum, Oren J. Cohen, Zilin Nie, Joel G. Weaver, Timothy S. Gomez, Xiao-Jian Yao, David Lynch, André A. Pilon, Nanci Hawley, John E. Kim, Zhaoxia Chen, Michael Montpetit, Jaime Sanchez-Dardon, Eric A. Cohen, Andrew D. Badley
Journal: Journal of Clinical Investigation (2003)

The absence of immune defects that occurs in the syndrome of long-term nonprogressive (LTNP) HIV infection offers insights into the pathophysiology of HIV-induced immune disease. The (H[F/S]RIG)2 domain of viral protein R (Vpr) induces apoptosis and may contribute to HIV-induced T cell depletion. We demonstrate a higher frequency of R77Q Vpr mutations in patients with LTNP than in patients with progressive disease. In addition, T cell infections using vesicular stomatitis virus G (VSV-G) pseudotyped HIV-1 Vpr R77Q result in less (P = 0.01) T cell death than infections using wild-type Vpr, despite similar levels of viral replication. Wild-type Vpr-associated events, including procaspase-8 and -3 cleavage, loss of mitochondrial transmembrane potential (Δψm), and DNA fragmentation factor activation are attenuated by R77Q Vpr. These data highlight the pathophysiologic role of Vpr in HIV-induced immune disease and suggest a novel mechanism of LTNP.
Detection of ras Gene Mutations in Human Lung Cancer: Comparison of Two Screening Assays Based on the Polymerase Chain Reaction
Authors: Kirsti Husgafvel-Pursiainen, Maaret Ridanpaa, Peter Hackman, Sisko Anttila, Antti Karjalainen, Agneta Onfelt, Anne-Lise Borresen, Harri Vainio
Journal: Environmental Health Perspectives (1992)

We studied the prevalence of point mutations in ras oncogenes (K-ras and N-ras) in DNA from white blood cells and tumor tissue from 36 untreated patients with non-small-cell lung cancer, all of whom were smokers or ex-smokers. We observed somatic K-ras mutations in one-third of the lung carcinomas studied but no N-ras mutation. K-ras codon 12 mutations were found more frequently in adenocarcinomas than in the other histopathological subtypes studied. More than 60% (10/16) of the lung adenocarcinomas had a codon 12 mutation, most of which were G to T transversions. No mutations was found in white blood cell DNA. Two polymerase chain reaction screening methods, oligonucleotide hybridization and denaturing gradient gel electrophoresis (DGGE), were used to detect the mutations. The oligonucleotide method appears to be more sensitive than DGGE, but DGGE proved to be a reliable nonradioactive method for rapid screening of point mutations in genes relevant to carcinogenesis.
PELVIC MASSAGE.
Authors: LLEWELLYN P. BARBOUR
Journal: JAMA (1899)

The recent papers in theJournal of the American Medical Associationdiscussing massage have been of much interest and of much worth to the general practitioner. It is to be regretted that this valuable remedial measure is not more widely appreciated by all who deal with pathologic conditions of the female pelvis. There is nothing in its technic that may not be done by the general practitioner with a good knowledge of the anatomy and physiology of the pelvis, and with ordinary dexterity. My attention was forcibly called to the subject six years ago by Dr. Dudley, of the New York Post-Graduate School, and the results I have since obtained have been a source of much satisfaction to me. I will report two recent cases, not because they surpass the success of the previous ones, but because they are recent, and because they serve as an example of what can
Electron-Beam Computed Tomography for Evaluating Coronary Artery Disease
Authors: Anthony S. Fiorino
Journal: Annals of Internal Medicine (1998)

Letters15 December 1998Electron-Beam Computed Tomography for Evaluating Coronary Artery DiseaseAnthony S. Fiorino, MD, PhDAnthony S. Fiorino, MD, PhDNew York, NY 10019Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-129-12-199812150-00026 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSEI appreciate Dr. Raggi's and Dr. Shields's comments. Dr. Raggi points out that electron-beam CT is the most sensitive tool available for the detection of minimal, subclinical disease, given that vascular remodeling may make lesions undetectable on angiography. Although the sensitivity of electron-beam CT is greater than that of other methods for the detection of non-flow-limiting lesions, some of these lesions may nevertheless be missed. Thus, the benefit lies in identifying patients with any calcium in their coronary arteries; if calcium is present, high-risk lesions are very likely. I look forward to further outcome studies that document electron-beam ...References1. Baumgart D, Schmermund A, Goerge G, Haude M, Ge J, Adamzik M, et al. Comparison of electron beam computed tomography with intra-coronary ultrasound and coronary angiography for detection of coronary atherosclerosis. J Am Coll Cardiol. 1997; 30:57-64. Google Scholar Author, Article, and Disclosure InformationAffiliations: New York, NY 10019 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 December 1998Volume 129, Issue 12Page: 1077KeywordsAngiographyCalciumComputed axial tomographyCoronary arteriesCoronary artery calcificationLesionsStable coronary artery diseaseStenosisUltrasound imagingVascular diseases Issue Published: 15 December 1998 CopyrightCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
A comparison of smoking patterns in the People's Republic of China with the United States. An impending health catastrophe in the middle kingdom
Authors: J. J. Yu
Journal: JAMA (1990)

Half of the global increase in tobacco use from 1976 to 1986 occurred in the People's Republic of China. In 1984, the first national smoking survey was conducted in China, involving over a half-million subjects. Sixty-one percent of Chinese males over age 15 smoke, with higher rates in all occupational groups than for corresponding groups in the United States. Current smoking patterns in China are similar to those in the United States during the 1950s, and these patterns forecast a steadily increasing epidemic of smoking-related deaths. It is estimated that by 2025, two million Chinese men will die annually from smoking. Foreign tobacco companies are mounting massive production and advertising campaigns in China. Government health education programs lack funds to counter these influences with sustained and comprehensive educational and interventional campaigns. To avert an impending national health catastrophe, China must launch a comprehensive smoking-control initiative aimed at public education, cessation, and legislation and policy. (<i>JAMA</i>. 1990;264:1575-1579)
Change to Licensing Type
Journal: JAMA Oncology (2020)

Toni K. Choueiri, MD; Daniel Y. C. Heng, MD; Jae Lyun Lee, MD; Mathilde Cancel, MD; Remy B. Verheijen, PhD; Anders Mellemgaard, MD; Lone H. Ottesen, MD; Melanie M. Frigault, PhD; Anne L’Hernault, PhD; Zsolt Szijgyarto, PhD; Sabina Signoretti, MD; Laurence Albiges, MD
Ximelagatran versus Warfarin To Prevent Blood Clots after Knee Replacement Surgery
Journal: Annals of Internal Medicine (2002)

Summaries for Patients15 October 2002Ximelagatran versus Warfarin To Prevent Blood Clots after Knee Replacement SurgerySearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-137-8-200210150-00003 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Deep venous thrombosis (DVT), a condition in which blood clots form in leg veins and cause pain and swelling, is a common complication of knee replacement surgery. Pieces of these clots can break off and travel to the lungs, causing a serious and potentially deadly condition called pulmonary embolism. To prevent DVT, doctors prescribe blood thinners around the time of knee replacement surgery. Warfarin is a common blood thinner used for this purpose. Unfortunately, up to almost half of patients still develop DVT after knee replacement surgery even ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Ximelagatran versus Warfarin for the Prevention of Venous Thromboembolism after Total Knee Arthroplasty. A Randomized, Double-Blind Trial.” It is in the 15 October 2002 issue of Annals of Internal Medicine (volume 137, pages 648-655). The authors are CW Francis, BL Davidson, SD Berkowitz, PA Lotke, JS Ginsberg, JR Lieberman, AK Webster, JP Whipple, GR Peters, and CW Colwell Jr.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoXimelagatran versus Warfarin for the Prevention of Venous Thromboembolism after Total Knee Arthroplasty Charles W. Francis , Bruce L. Davidson , Scott D. Berkowitz , Paul A. Lotke , Jeffrey S. Ginsberg , Jay R. Lieberman , Anne K. Webster , James P. Whipple , Gary R. Peters , and Clifford W. Colwell Jr. Metrics 15 October 2002Volume 137, Issue 8Page: I-38KeywordsBloodDeep vein thrombosisHematologic testsHemorrhageKneesPulmonary embolismSurgeryThrombosisTotal hip replacementVenous thromboembolism ePublished: 15 October 2002 Issue Published: 15 October 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Decreasing Liver Biopsy Complications
Authors: Keith D. Lindor
Journal: Annals of Internal Medicine (1993)

Letters1 September 1993Decreasing Liver Biopsy ComplicationsKeith D. Lindor, MD and Christine H. Janes, MDKeith D. Lindor, MDSearch for more papers by this author and Christine H. Janes, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-5-199309010-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We are aware of literature, based on retrospective data, suggesting that the Menghini needle is associated with fewer complications than the Tru-Cut needle; however, to our knowledge, randomized comparative trials of the two types of needles in an adequate number of patients have not been reported. We chose the cutting-type needle because many of our patients have relatively advanced fibrotic liver disease. Our general impression, and that of others, suggests that this type of needle has a better rate of retrieval of interpretable tissue than the aspiration-type needles.Common sense dictates that the more experience an operator has ... Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1993Volume 119, Issue 5Page: 436-437KeywordsBiopsyLiverLiver diseasesOrthotopic liver transplantation ePublished: 15 August 2000 Issue Published: 1 September 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Silent victims. Children who witness violence
Authors: B. M. Groves
Journal: JAMA (1993)

THE CRISIS of violence in the United States has expanded to include more than the traditional emphasis on the victim and perpetrator. We would like to bring attention to a previously underrecognized group of victims in this public health epidemic: the children who witness the violence. These usually silent, indirect victims show no physical sign of harm and are commonly overlooked. In urban pediatric practices, clinicians increasingly are told that their young patients hear gunshots outside their homes, witness shootings on the playground, or have a family member (often an older sibling) involved with violence. Recent studies support this. One of every 10 children attending Boston (Mass) City Hospital pediatric primary care clinic witnessed a shooting or stabbing before the age of 6 years,<sup>1</sup>half in the home, half on the streets. The average age of the children in this study was 2.7 years. A survey of elementary-school-aged children
Persistence of efficacy of three antiemetic regimens and prognostic factors in patients undergoing moderately emetogenic chemotherapy. Italian Group for Antiemetic Research.
Journal: Journal of Clinical Oncology (1995)

PURPOSE To evaluate antiemetic efficacy and tolerability of granisetron, dexamethasone, and their combination over repeated courses of moderately emetogenic chemotherapy, and the influence of the prognostic factors on occurrence of nausea and vomiting. PATIENTS AND METHODS Four hundred twenty-eight consecutive cancer patients were entered onto a multicenter, randomized, double-blind study to compare granisetron 3 mg intravenously, dexamethasone 8 mg intravenously, and 4 mg orally every 6 hours for four doses, or the combination of dexamethasone plus granisetron at the same doses, administered for three consecutive cycles. Occurrence of nausea, retching, and vomiting was monitored for 24 hours after chemotherapy administration by a diary card. RESULTS Three hundred ninety-eight patients were assessable for clinical efficacy at the first cycle, 354 were assessable at the second cycle, and 322 were assessable at the third cycle of chemotherapy. Dexamethasone plus granisetron induced significantly greater complete protection from vomiting, nausea, and both nausea and vomiting than granisetron alone in all three cycles. With respect to dexamethasone alone, complete protection from vomiting was significantly greater at the first and second cycle, and complete protection from nausea and from both nausea and vomiting only at the first cycle. Complete protection did not differ significantly among the three cycles in patients receiving dexamethasone plus granisetron or dexamethasone alone, whereas it decreased significantly, at least for vomiting, in patients receiving granisetron alone. Protection obtained in the previous cycle of chemotherapy was the most important prognostic factor in the occurrence of nausea and vomiting. CONCLUSION The combination of dexamethasone plus granisetron offers the best antiemetic protection because of its greater efficacy with respect to the other two regimens at first cycle, and because its activity is maintained in the subsequent cycles of chemotherapy.
American Journal of Digestive Diseases, New York
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Railroad Rates.
Authors: Henry C. Fairbank
Journal: JAMA (1894)

Flint, Mich., April 9,1894. <h3>To the Editor:</h3> —I wish to emphasize all that Dr. Daniel Lichty, of Rockford, says in your issue of the 7th inst., in reference to railroad transportation for members of ourAssociationand their families, who have in the past, and who want to attend in the future the annual meetings of theAssociation. Joining theAssociationmyself at the New Orleans meeting in 1869, and attending its annual gatherings quite regularly for several years thereafter, I found that the comparatively small rebate in railroad fares afforded members, together with the necessary drafts upon time and purse, were a serious consideration when contemplating a trip to the place of meeting, each year, and have been among the absentees for several years past. The first meeting of theAssociationin San Francisco was held when money was plenty and the U. P. and C. P. railroads were
Deaths
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Teenage suicide clusters
Authors: M. S. Gould
Journal: JAMA (1990)

<h3>In Reply.—</h3> Dr Gould raises important points in directing attention to our study's limited ability to assess the relationship between media exposure and suicide risk and to the possibility of selection bias. Her first point is that the control subjects lived longer than the suicide cases and thus they had more chances than the case subjects to be exposed to media coverage of the suicides. We recognized that earlier case subjects had fewer opportunities for media exposure than control subjects and stated that our small number of cases precluded analysis by opportunity for exposure. However, since exposure via television was reported for only 1 of the 13 case subjects, we believe that the differences are actual and cannot be solely ascribed to increasing opportunities for exposure during the series. Still, we agree with Dr Gould's point and believe that it would have been better to state that our study data