tbuckley/cabot-search huggingface dataset:
Abstract 3467: Fibulin-2 Enhances Angiotensin-II-Induced Transforming Growth Factor (TGF)-β Activation in Promoting Cardiac Remodeling in the Mouse Model I <i>n Vivo</i>
Authors: Hangxiang Zhang, Hailong Dong, Jing Wu, Mon-Li Chu, Takeshi Tsuda
Journal: Circulation (2008)

Background: Angiotensin-II (Ang-II) is a potent neurohormone responsible for progression of cardiac remodeling in which TGF-β serves as a principal downstream mediator. In our previous study, genetic deletion of fibulin-2 attenuated progression of ventricular dysfunction after experimental myocardial infarction (MI). Because Ang-II plays a central role in post-MI ventricular remodeling, we tested the hypothesis that fibulin-2 modulates Ang-II-induced cardiac remodeling. Methods: Subpressor dosage of Ang-II (0.2 μg/kg/min) was infused over 4 weeks by mini-osmotic-pump in age matched wild-type (WT), heterozygous, and fibulin-2 null (Fbln2 −/− ) adult male mice. Sham mice received normal saline. Results: There was no blood pressure change throughout Ang-II treatment. WT developed significant left ventricular (LV) hypertrophy by Ang-II, whereas Ang-II-treated Fbln2 −/− mice showed no noticeable hypertrophy compared with sham: LV/body weight ratio (WT 4.83±0.18 vs. Fbln2 −/− 4.01± 0.12 mg/g, p &lt; 0.05) and LV posterior wall thickness by echocardiogram (WT 0.76± 0.03 vs. Fbln2 −/− 0.71± 0.02 mm, p &lt; 0.05). Atrial natriuretic peptide (ANP) mRNA expression was significantly increased in Ang-II-treated WT compared with sham, but not in Ang-II-treated Flbn2 −/− . Ang-II also induced significant up-regulation in fibulin-2, Collagen I, Collagen III, and MMP-2 mRNA level in WT, but not in Fbln2 −/− . Both TGF-β1 mRNA and protein expression were significantly up-regulated in Ang-II-treated WT, but were unchanged in Ang-II-treated Fbln2 −/− compared with sham. Activation of TGF-β downstream signaling proteins, phosphorylated forms of Smad2, TGF-β-activated kinase 1 (TAK1), and p38MAPK, were all significantly increased in Ang-II-treated WT, as opposed to no increase in Ang-II-treated Fbln2 −/− compared with sham. Heterozygous mice showed intermediate increase in LV hypertrophy, matrix protein synthesis, and activation of TGF-β downstream signaling pathways between WT and Fbln2 −/− . Conclusions: Our data suggest that fibulin-2 enhances Ang-II-induced myocardial hypertrophy via up-regulation of TGF-β and its downstream signaling pathways in dose-dependent fashion and that fibulin-2 is required for Ang-II-induced TGF-β activation. This research has received full or partial funding support from the American Heart Association, AHA Great Rivers Affiliate (Delaware, Kentucky, Ohio, Pennsylvania &amp; West Virginia).
Tobacco, Policy
Authors: Jonathan M. Samet, Heather L. Wipfli
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Portal Hypertension
Authors: Carroll M. Leevy, Gilbert R. Cherrick, Charles S. Davidson
Journal: New England Journal of Medicine (1960)

SEQUELAE of portal hypertension directly or indirectly constitute the principal cause of morbidity and mortality in chronic liver disease. The pathologic physiology of this state is incompletely understood, and many of the therapeutic measures in current use are unsatisfactory. Nevertheless, considerable information concerning the mechanics of portal hypertension has recently been gained by correlation of indirect measurements of portal pressure with clinical and biochemical findings, histology and radiologic study of the vascular bed of the liver. Although the results of such studies have not yet significantly altered therapy for complications of this state, they provide new information that should be . . .
The Hydriatic Treatment of Typhoid Fever
Journal: JAMA (1892)

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Meetings of Medical Interest
Journal: JAMA (2003)

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Cervical Cancer Consensus
Journal: JAMA (1996)

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Correction: Dog's Milk in Infant Feeding.
Journal: JAMA (1920)

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NETHERLANDS
Journal: JAMA (1930)

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Acute Glutethimide Poisoning
Authors: Noel Wright
Journal: JAMA (1970)

Glutethimide poisoning occurred in 31 patients. They were treated by intensive supportive therapy; no patient was treated with hemodialysis. The overall mortality of 3% (one) in this series compares favorably with that of other series. It is concluded that hemodialysis is not essential in the management of severely poisoned patients.
THE PROMOTION OF GROWTH
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
QuickStats: Prevalence* of Anemia† Among Adults Aged ≥65 Years, by Sex and Age Group — National Health and Nutrition Examination Survey, 2013–2016
Journal: MMWR Morbidity and Mortality Weekly Report (2018)

Age group (yrs) [75][76][77][78][79][80][81][82][83][84] Percentage * With 95% confidence intervals indicated with error bars.† Anemia was defined using World Health Organization standards: hemoglobin <13 g/dL for men and <12 g/dL for women.During 2013-2016, the prevalence of anemia among persons aged ≥65 years increased with increasing age for both men and women.Among men, the prevalence increased from 7.4% for those aged 65-74 years to 39.5% for those aged ≥85 years.The percentage of women with anemia increased from 7.6% for those aged 65-74 years to 21.9% for those aged ≥85 years.The prevalence of anemia was higher for men compared to women among those aged 75-84 years and those aged ≥85 years.
Introduction to Physiological and Pathological Chemistry
Journal: JAMA (1953)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Retinoid Metabolism and Mode of Action
Authors: Luigi M. De Luca, Wlodzimierz Sasak, Sergio Adamo, Pangala V. Bhat, Irene Akalovsky, Carol S. Silverman-Jones, Nancy Maestri
Journal: Environmental Health Perspectives (1980)

Vitamin A and its derivatives (retinoids) are necessary for the maintenance of normal phenotypic expression.An attempt at understanding the biochemical role of vitamin A has led to the demonstration of a new pathway for retinol.In this pathway, vitamin A is phosphorylated to retinylphosphate (RP), which is then glycosylated to retinylphosphatemannose (MRP).These two derivatives have been found in a variety of tissues in vivo and in vitro and appear to be ubiquitous components of cellular membranes.The suggestion has been made that MRP may mediate specific cellular interactions by functioning as a lipid intermediate in the biosynthesis of specific glycoconjugates.A study on spontaneously-transformed mouse fibroblasts (Balb/c 3T12-3 cells) has shown that retinoids are active in increasing the adhesive properties ofthese cells as measured in an EDTA-mediated detachment assay.Various retinoids were tested for their activity in the adhesion test, and this activity was found to correlate well with their biological activity in maintaining the expression of normal epithelial differentiation in other systems.Retinoic acid, 5,6-epoxyretinol, and 5,6-epoxyretinoic acid were the most active compounds.Retinoids without biological activity in other systems were also inactive in inducing adhesive properties of 3T12-3 cells.Among these were the synthetic derivatives of retinol, anhydroretinol, and 4,5-monoeneperhydroretinol, and the phenyl derivative of retinoic acid./3-Ionone, abscisic acid, and juvenile hormone, which are devoid of vitamin A activity in other systems, were also inactive in this system.Retinoid-induced changes in cell surface proteins were investi- gated but no difference in 1251-fibronectin (MW 220,000) was detectable between retinoid-treated and untreated cells.However, these cells synthesized retinylphosphatemannose and the incorporation of 2-3H- mannose into a specific glycoprotein (gp 180) was found to be enhanced specifically by retinoid treatment.Investigations of the involvement of gp 180 in adhesion are in progress.
Evidence for spontaneous immunosuppression in autoimmune hepatitis*1
Authors: A LOHSE
Journal: Hepatology (1995)

Autoimmune hepatitis (AIH) runs a variable clinical course. Slow disease progression or even spontaneous remissions can be observed and suggest that the autoimmune process can, at least to a certain extent, be controlled by regulatory elements of the patient's own immune system. In experimental autoimmune hepatitis (EAH) spontaneous recovery is regularly observed and associated with antigen-specific and antigen-nonspecific suppression. The aim of the current study was to search for similar immunoregulatory phenomena in patients with AIH. We examined T-cell reactivity to soluble human liver antigens in 11 patients with active autoimmune hepatitis and 30 patients with other liver diseases (chronic viral hepatitis, primary biliary cirrhosis, fatty liver). T-cell reactivity to liver antigens was almost exclusively confined to the AIH patients. In 9 of these 11 patients we were able to compare the T-cell response in active untreated disease, directly after initiation of immunosuppressive therapy and in remission, at which point T-cell reactivity was found to be markedly reduced. Addition of irradiated peripheral blood cells from the active disease phase or the remission phase to the responding cells taken before treatment showed that in eight of the nine patients there was marked suppression of the liver-specific T-cell response by cells from the remission phase. Study of the in vivo immune responsiveness by giving a tetanus toxoid booster immunization to nine patients with active untreated AIH as well as healthy controls and patients with other liver diseases showed that none of the patients with AIH showed a response to the tetanus immunization, whereas almost all the other patients showed marked responses. Taken together these results show the presence of active suppression of T-cell autoreactivity in vitro in AIH and marked nonresponsiveness to in vivo challenge with an unrelated antigen, suggesting generalized spontaneous immunosuppression that is more pronounced in vivo than what can be measured in vitro. Spontaneous immunosuppression, however, is not sufficient to effectively suppress the disease process. Immunosuppressive therapy is required for remission induction, but is apparently helped by the patient's own immunoregulatory activity. These observations support the concept of peripheral control mechanisms being operative in patients with AIH, and these could be the basis for a more effective and specific immunotherapy of this condition in the future.
Chelation therapy in workers exposed to lead. A critical review
Authors: R. Lilis
Journal: JAMA (1976)

THE ACCELERATED rate of development of modern technology has considerably expanded the range of possible occupational health hazards. Unfortunately, other industrial health hazards known for centuries and extensively studied have not been completely eliminated, and disease continues to be seen. Inorganic lead is probably one of the most obvious examples of such long-known occupational hazards. The detection of lead poisoning, its diagnosis, treatment, and possible long-term effects remain areas of scientific and practical interest; much progress has been achieved in the last two decades. Chelation therapy in lead poisoning represented one such advance, and experience accumulated over 20 years has largely confirmed its effectiveness.<sup>1</sup> Among the various chelating agents, the polyaminocarboxylic acids and particularly edetate disodium calcium have emerged as the agents of choice for the treatment of lead poisoning. Edetate disodium calcium has been shown, in terms of lead elimination and excretion, to be superior to both dimercaprol
Five New Pedigrees with Inherited RUNX1 Mutations Causing Familial Platelet Disorder with Propensity to Myeloid Malignancy (FPD/AML)
Authors: Carolyn J Owen, Cynthia L Toze, Anna Koochin, Donna L. Forrest, Clayton A. Smith, Shannon C Jackson, Man-Chiu Poon, Gary D. Sinclair, Brian Leber, Peter Johnson, Anthony Macheta, John AL Yin, Michael J. Barnett, T. Andrew Lister, Jude Fitzgibbon
Journal: Blood (2008)
Universal screening for diabetes in patients aged over 45 should not be adopted in Britain
Journal: BMJ (2001)

Meningitis in infancy leads to developmental disabilitiesChildren who have meningitis in infancy have a 10-fold increase in the risk of developing permanent severe or moderate disabilities.Bedford et al (p 533) followed up 1717 children aged 5 years who had had meningitis.General practitioners and parents completed questionnaires about the health and development of 1584 children who had had meningitis and 1391 control children.Those in the meningitis group were more likely to have subtle deficits, such as middle ear disease and visual and behavioural problems.There was considerable variation in outcome depending on the age at infection and the causative organism.All children who have had meningitis should be carefully assessed. Post-traumatic stress disorder is a valid and useful diagnosisPost-traumatic stress disorder is a valid and useful diagnosis but it is not the only psychiatric response to trauma.The disorder is associated with high rates of psychiatric comorbidity and impaired social and occupational functioning and has a prevalence of 1%-7.8% in the general population.Mezey and Robbins (p 561) argue that the diagnosis of post-traumatic stress disorder is important for both patients and doctors and that it can be differentiated from other psychiatric diagnoses by biochemical, neuroanatomical, and phenomenological characteristics.Any concerns about the diagnosis in victims of chronic and lifelong trauma could be resolved by further refining the diagnostic criteria.