tbuckley/cabot-search huggingface dataset:
Handbuch der inneren Sekretion. Eine umfassende Darstellung der Anatomie, Physiologie und Pathologie der endokrinen Drüsen.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Errata
Authors: Thomas Cossar, Joseph Eastwood, Derbyshire Chesterfield, John Langdon, David Mickle, John Roiuse, Great Torrington, Devon August, Burton Crescent, Francis Beall
Journal: BMJ (1851)

The great lengtlh of the report of the Meeting at Brighton prevented our inserting the annexed statemert in its proper place in the business part of the Anniver- sary, and we now place it before our readers withl other matters connected with the late meeting.
Function of ε-Aminocaproic Acid
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 1905: Quantification Of Macrophages In Atherosclerotic Plaques Of Rabbits Using The Novel Specific Ct Contrast Agent N1177: A Comparison With 18f-fdg Uptake On Pet-ct And Histology
Authors: Fabien Hyafil, James H Rudd, Jean-Christophe Cornily, Ash Rafique, Laurent J Feldman, Josef Machac, Valentin Fuster, Zahi A Fayad
Journal: Circulation (2007)

Introduction. N1177 is a novel computed tomography (CT) contrast agent taken up by macrophages. Purpose. We tested if the enhancement detected on CT in aortic wall of rabbits 2 hours after injection of N1177 correlates with metabolic activity measured with 18F-FDG uptake on positron emission tomography (PET)-CT and macrophage area on histology. Methods. Atherosclerotic plaques were induced in the aorta of 7 New-Zealand White rabbits by a repeated balloon injury (4 weeks apart) and 4 months of hyperlipemic diet. Three non-injured rabbits fed a chow diet were used as controls. A CT of the aorta (n=10) was acquired in each rabbit before and 2 hours after intravenous injection of N1177 (250 mg iodine/kg). One week later, the same rabbits were imaged on a PET-CT 3 hours after injection of 1 mCi/kg of 18F-FDG. Enhancement of the aortic wall after injection of N1177 was compared to the SUV on PET-CT, and to macrophage area on immunohistochemistry (anti-RAM-11 antibody) of corresponding sections. Results. A significant higher enhancement was measured on N1177-enhanced CT in the aortic wall of atherosclerotic compared to control rabbits (mean increase of 10.0 ± 5.2 Hounsfield Units vs. 2.0 ± 2.1 HU, respectively; p&lt;0.05). We found a strong correlation between the enhancement of the aortic wall measured on N1177-enhanced CT (Fig .: before (A) and 2 hours after (B) injection of N1177) and FDG uptake on PET-CT (Fig. C ; r=0.61, p&lt;0.001), macrophage area on immunohistology (Fig. D ; r=0.63, p&lt;0.001). Conclusion. Enhancement detected in the aortic wall of rabbits with N1177-enhanced CT correlated with intense metabolic activity measured with 18-F-FDG on PET-CT and with macrophage area on histology.
Hypoglycemia in a Patient with a Fibrous Tumor
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Feeling Death
Authors: C. Scott Williams
Journal: Annals of Internal Medicine (2009)

Ad Libitum16 June 2009Feeling DeathC. Scott Williams, MDC. Scott Williams, MDFrom Huntsville, AL 35801.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-150-12-200906160-00010 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail If death is a fingerGrief is its print,The lasting mark,The light blocking smudge,The opacity of soul,The unique ridgesOf rising and falling selfCircling nowhere and back.If death is a handGrief is its grip,The tearful tetanyThat cannot let go,The terrified squeezeDesperately clingingTo that which cannotBe held any longer.C. Scott Williams, MDFrom Huntsville, AL 35801. Author, Article, and Disclosure InformationAffiliations: From Huntsville, AL 35801.Current Author Address: C. Scott Williams, MD, 420 Lowell Drive, Suite 107, Huntsville, AL 35801. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 16 June 2009Volume 150, Issue 12Page: 868KeywordsEmotionsHand strength ePublished: 16 June 2009 Issue Published: 16 June 2009 Copyright & PermissionsCopyright © 2009 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
<i>Annual and Analytical Cyclopedia of Practical Medicine.</i>By Chas. E. De M. Sajous and one hundred associate editors, assisted by corresponding editors, collaborators and correspondents. Illustrated with chromolithographs, engravings and maps. Vol. I. Philadelphia, New York, Chicago. The F. A. Davis Company, publishers, 1898
Authors: H. M. B.
Journal: American Journal of Psychiatry (1898)
Metabolites and analogues of vitamin D. Which for what?
Authors: M. R. Haussler
Journal: JAMA (1982)

The discovery and chemical synthesis of several biologically active derivatives of vitamin D have increased the number of compounds available for the treatment of disorders of bone and mineral metabolism. Calcitriol is the most active natural metabolite of vitamin D, but analogues like dihydrotachysterol and calcifediol also are safe and effective therapeutic agents. These vitamin D congeners have been useful in the treatment of renal osteodystrophy, hypoparathyroidism, and other disorders refractory to vitamin D therapy. Certain analogues may offer distinct advantages over vitamin D, depending on the nature of the defect. All vitamin D derivatives should be used cautiously, with frequent monitoring of serum calcium levels to prevent toxic reactions. (<i>JAMA</i>1982;247:841-844)
BOOK REVIEWS
Journal: JNCI Journal of the National Cancer Institute (1991)

BOOK REVIEWS Get access Prostate Cancer and Testicular Cancer: Progress in Clinical and Biological Research, Volume 357 . Donald W. W. Newling , William G. Jones , eds. New York : Wiley-Liss , 1990 , 348 pp. $79.95. JNCI: Journal of the National Cancer Institute, Volume 83, Issue 5, 6 March 1991, Page 365, https://doi.org/10.1093/jnci/83.5.365 Published: 06 March 1991
Epilepsy
Authors: H. A. Ring
Journal: Clinical Nuclear Medicine (1998)

Epilepsy was described by Hughlings Jackson in 1886 as involving 'sudden, excessive, rapid and local discharges of the grey matter' of the brain. This simple definition remains a useful summary of the phenomenon. Epilepsy is relatively common. In both the UK and the USA, studies suggest that five out of each thousand people will suffer from the condition. The incidence is highest in childhood and lowest in middle life. It has been estimated that approximately 5% of the population will have at least one seizure at some time in their life.KeywordsPositron Emission TomographyTemporal Lobe EpilepsyEpileptic FocusTransient Global AmnesiaJuvenile Myoclonic EpilepsyThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
FRI0010 Identification of an Antigen-Specific Regulatory B Cell Subset in Humans
Authors: J.-O. Pers, L. Le Pottier, C. Goutsmedt
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Several studies in mice have suggested that the B cell receptor (BCR) stimulation in addition to CD40 was required for regulatory B cell (Breg) development. Fault of model in humans, the effect of an antigen-specific stimulation on the regulatory function of B cells has never been studied. <h3>Objectives</h3> We took advantage of the influenza vaccination campaign to study the regulatory function of B cells in response to hemagglutinin (HA), the antigen contained in the vaccine. <h3>Methods</h3> B and T cells were isolated from blood of 19 healthy donors before (W0), 3 weeks (W3), 3 months and 6 months after vaccination. To evaluate the functional regulatory properties of peripheral blood B cells in the presence or absence of rHA (antigen-specific stimulation) or a (Fab9)2 anti-IgM Ab used to stimulate BCR (polyclonal stimulation), a co-culture assay was performed to assess the ability of pre-activated B cells with multimeric forms of CD40L to inhibit polyclonal anti-CD3 and anti-CD28 Ab-induced proliferation of autologous T cells. Antigen specific B cells (B HA+) have been phenotyped by FACS. <h3>Results</h3> Influenza vaccination induces HA specific B cells (B HA+) (2.52±0.1% at W3 versus 0.95±0.1% at W0, p&lt;0.001). Before vaccination, when B cells were added to the co-culture assay, the proliferative response of T cells was inhibited by 19.2±2.5%, confirming their regulatory function. The addition of rHA has no additive effect whilst BCR engagement enhanced the suppressive effect of B cells on T cell proliferation (21.1±2.6% vs 35.3±3.8%, p&lt;0.005). Interestingly, when the same experiment was performed 3 weeks after influenza vaccination, the presence of rHA in the co-culture assay increased the regulatory function of B cells (32.7±3.5% of T cell proliferation inhibition with rHA versus 22.6±2.6% without rHA, p&lt;0.001) without achieving the inhibition of T cell proliferation observed after BCR engagement (37.3±4.3%). The regulatory functions of B cells pass through the induction of regulatory T cells and the secretion of TGFβ in an IL-10-independent manner. We identified by FACS analysis after vaccination, a B cell subset specific for HA (CD19+ HA+ IgD+ CD38+ CD27- CD24- CD22+) that was positively correlated with the increase in the inhibition of T cell proliferation in response to HA. <h3>Conclusions</h3> After vaccination, an antigen-specific B cell subset prone to be induced in Bregs is generated in addition to antigen-specific effector B cells. <h3>Disclosure of Interest</h3> None declared
Bats, Mosquitoes and Dollars.
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstracts
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dementia and Hypoglycemic Episodes in Patients With Type 2 Diabetes Mellitus—Reply
Authors: Rachel A. Whitmer
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Perioperative Nutrition
Authors: JEFFREY ASKANAZI
Journal: Annals of Internal Medicine (1988)

Letters and Corrections1 June 1988Perioperative NutritionJEFFREY ASKANAZI, M.D., VLADIMIR KVETAN, M.D., TERRY HENSLE, M.D.JEFFREY ASKANAZI, M.D.Search for more papers by this author, VLADIMIR KVETAN, M.D.Search for more papers by this author, TERRY HENSLE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-108-6-912_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We are responding to the position and background papers on perioperative nutrition in the August 1987 issue (1, 2). Citing the iatrogenic complications from parenteral nutrition the authors concluded that although perioperative nutrition may be justified in certain high-risk patients, further studies were needed to show its effectiveness in other patient populations, particularly previously well-nourished patients.Hyperalimentation, total parenteral nutrition, parenteral nutritional support, and parenteral feedingwere used interchangeably in both papers, although these terms can have very different meanings. Although different nutrient compositions will have different rates of effectiveness and complications in different patient groups, no attempt...References1. . Perioperative parenteral nutrition: a position paper. Ann Intern Med. 1987;107:252-3. LinkGoogle Scholar2. DETSKY A, BAKER J, O'ROURKE K, and GOEL V. Perioperative parenteral nutrition: a meta-analysis. Ann Intern Med. 1987;107:195-203. LinkGoogle Scholar3. STARKER P, LASALA P, and ASKANAZI J. Placement of Broviac catheters for total parenteral nutrition. Surg Gynecol Obstet. 1983;156:229-30. MedlineGoogle Scholar4. ASKANAZI J, HENSLE T, and STARKER P. Effect of immediate postoperative nutritional support on length of hospitalization. Ann Surg. 1986;203:236-9. CrossrefMedlineGoogle Scholar5. FOSTER K, ALBERTI K, and ALLEN N. The influence of early post-operative intravenous nutrition on recovery after total cystectomy. Br J Urol. 1978;50:319-23. CrossrefMedlineGoogle Scholar6. STARKER P, LASALA P, ASKANAZI J, TODD G, HENSLE T, and KINNEY J. The influence of preoperative total parenteral nutrition upon morbidity and mortality. Surg Gynecol Obstet. 1986;162:569-74. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JEFFREY ASKANAZI, M.D.; VLADIMIR KVETAN, M.D.; TERRY HENSLE, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1988Volume 108, Issue 6Page: 912-912KeywordsNutrientsNutritionPopulation statisticsTotal parenteral nutrition ePublished: 1 December 2008 Issue Published: 1 June 1988 PDF downloadLoading ...
"Swiss Cheese" Nuclei: An Incubation Deduced Lesion of Infectious Mononucleosis Lymphocytes
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Nuclear Receptor Corepressor (NCoR) Controls Thyroid Hormone Sensitivity and the Set Point of the Hypothalamic-Pituitary-Thyroid Axis
Authors: Inna Astapova, Kristen R. Vella, Preeti Ramadoss, Kaila A. Holtz, Benjamin A. Rodwin, Xiao-Hui Liao, Roy E. Weiss, Michael A. Rosenberg, Anthony Rosenzweig, Anthony N. Hollenberg
Journal: Endocrine Reviews (2011)

The role of nuclear receptor corepressor (NCoR) in thyroid hormone (TH) action has been difficult to discern because global deletion of NCoR is embryonic lethal. To circumvent this, we developed mice that globally express a modified NCoR protein (NCoRΔID) that cannot be recruited to the thyroid hormone receptor (TR). These mice present with low serum T4 and T3 concentrations accompanied by normal TSH levels, suggesting central hypothyroidism. However, they grow normally and have increased energy expenditure and normal or elevated TR-target gene expression across multiple tissues, which is not consistent with hypothyroidism. Although these findings imply an increased peripheral sensitivity to TH, the hypothalamic-pituitary-thyroid axis is not more sensitive to acute changes in TH concentrations but appears to be reset to recognize the reduced TH levels as normal. Furthermore, the thyroid gland itself, although normal in size, has reduced levels of nonthyroglobulin-bound T4 and T3 and demonstrates decreased responsiveness to TSH. Thus, the TR-NCoR interaction controls systemic TH sensitivity as well as the set point at all levels of the hypothalamic-pituitary-thyroid axis. These findings suggest that NCoR levels could alter cell-specific TH action that would not be reflected by the serum TSH.
A study of workers exposed to detergent enzymes
Authors: H. Weill
Journal: JAMA (1971)

Respiratory symptoms in detergent-industry workers have been associated with exposure to the dust of proteolytic enzymes derived from<i>Bacillus subtilis</i>. This study characterizes the clinical and physiologic features in affected workers and relates them to environmental exposure and skin test response to the enzyme extract. Sensitization was common. Less frequent were symptoms which typically included cough, wheezing, chest tightness, and dyspnea appearing several hours after leaving work. Airways obstruction was not accompanied by the constitutional, roentgenographic, or pulmonary function abnormalities usually associated with the alveolar inflammatory reactions encountered after exposure to some organic dusts. Symptomatic workers frequently had an atopic history and positive skin test and usually improved after reduction or elimination of exposure. Analysis of physiologic data in exposed groups suggests that chronic irreversible impairment of pulmonary function has not occurred.