tbuckley/cabot-search huggingface dataset:
Risk Factors for the Development of Cholelithiasis in Man
Authors: Lynn J. Bennion, Scott M. Grundy
Journal: New England Journal of Medicine (1978)

Conditions Associated with Pigment StonesThe demographic characteristics of persons at high risk for pigment gallstones differ from those in whom cholesterol stones are likely to develop, as noted in Table 1. Pigment stones are notably rare among American Indians, who have very high rates of cholesterol cholelithiasis,49-51 and whereas cholesterol gallstones predominate in Northern Europe52 and North and South America,53-56 pigment stones are more prevalent in the rural Orient.37,56,57 In Japan, however, the pattern has been shifting over the past several decades, with pigment stones becoming less, and cholesterol stones more, frequent.58-60 This shift has . . .
Conservative treatment of rectal tumours.
Journal: BMJ (1978)

Finally, the mode of onset of labour deserves special con- sideration in patients with unstable lie, malpresentation, or polyhydramnios.In these circumstances there is much to commend elective amniotomy in a controlled fashion in an operating theatre rather than for the obstetrician to wait for spontaneous rupture of the membranes.If the cord is going to prolapse it is preferable that it should do so while the opera- tor's fingers are still within the vagina.This approach also permits him to apply a monitoring electrode at the earliest possible moment.
A SIRT2-Selective Inhibitor Promotes c-Myc Oncoprotein Degradation and Exhibits Broad Anticancer Activity
Authors: Hui Jing, Jing Hu, Bin He, Yashira L. Negrón Abril, Jack Stupinski, Keren Weiser, Marisa Carbonaro, Ying-Ling Chiang, Teresa Southard, Paraskevi Giannakakou, Robert S. Weiss, Hening Lin
Journal: Cancer Cell (2016)
THE PHYSIOLOGIC PSYCHOLOGY OF SMELLING.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fluoroscopically assisted biopsy for mid and peripheral lung lesions
Authors: S. S. Sagel
Journal: JAMA (1974)

THE determination of the etiology of a pulmonary infiltrate or mass lesion seen in the middle third or periphery of the lung on a chest roentgenogram, is a common clinical problem. In many instances, following exclusion of a systemic disease process, the pulmonary disease cannot be diagnosed by the usual clinical work-up: sputum examination and culture (including transtracheal aspiration), serologic studies, and other procedures. Establishment of the nature and cause of the lesion or lesions depends on examination of tissue from the roentgenographically demonstrated pulmonary density. The ideal diagnostic test, with no risk and 100% yield, unfortunately does not exist. Diagnostic thoracotomy is unquestionably the most reliable method of diagnosis. However, it is also the most expensive, painful, and dangerous. A fundamental logic in medicine dictates that the procedure least likely to injure should be used first, before progressing to the more dangerous, discomforting, and expensive technique. <h3>Fiberoptic Bronchoscopy</h3> Regarding
DIET AND RELIEF
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 3946: Molecular Identification and Characterization of a Novel Gene that Regulates Endothelial Cell Apoptosis and Angiogenesis
Authors: Koji Ikeda, Masahiro Koide, Maki Uraoka, Yusuke Nakagawa, Ritsuko Nakano, Hiroaki Matsubara
Journal: Circulation (2008)

Endothelial apoptosis is a pivotal process for angiogenesis during embryogenesis as well as postnatal life. Here, we identified and characterized a novel gene (ARIA) that regulates endothelial apoptosis and angiogenesis. ARIA was expressed in a variety of human cultured endothelial cells as well as in blood vessels of e9.5d mouse embryos, suggesting its role in angiogenesis. Amino acid sequence analysis revealed that ARIA is a novel membrane protein with no homology to conserved domain structures reported before. Knockdown of ARIA in HUVEC using siRNA resulted in significant reduction of endothelial apoptosis. In contrast, ARIA-knockdown did not affect either endothelial cell migration or proliferation. Among factors associated with apoptosis, inhibitor of apoptosis (cIAP)-1 and cIAP-2 protein expression was significantly increased by ARIA-knockdown whereas their mRNA level was not changed. cIAP-1 and cIAP-2 play as ‘gardians’ of the cell death machinery by directly bind to and neutralize caspases as well as by modulate death signaling of TNF receptors. Simultaneous knockdown of cIAP-1 and cIAP-2 abolished the anti-apoptotic effect of ARIA-knockdown. On the other hand, yeast two-hybrid screening using the putative intracellular domain of ARIA as the bait identified the 20S proteasome α subunit-7 as a binding partner of ARIA. Proteasomal inhibition significantly increased cIAP-1 and cIAP-2 expression in HUVEC, indicating their proteasomal degradation in endothelial cells. ARIA-knockdown cancelled this effect of proteasomal inhibition. ARIA-knockdown also mimicked proteasomal inhibition with respect to the expression and subcellular localization of cIAP-1 and cIAP-2 in HUVEC. These results strongly suggest that ARIA plays crucial roles in the proteasomal degradation of cIAP-1 and cIAP-2 in endothelial cells via its interaction with the 20S proteasome α subunit-7. Furthermore, in vivo angiogenesis assessed by Matrigel-plug assay was significantly enhanced by ARIA-knockdown. Taken together, ARIA is a novel factor regulating endothelial apoptosis and angiogenesis through modulating proteasomal degradation of cIAP-1 and cIAP-2. Inhibition of ARIA could be a novel target for developing the better therapeutic angiogenesis.
RESPONSE: Re: Metabolites of a Tobacco-Specific Lung Carcinogen in Nonsmoking Women Exposed to Environmental Tobacco Smoke
Authors: K. E. Anderson, S. S. Hecht, R. L. Bliss, C. Le
Journal: JNCI Journal of the National Cancer Institute (2001)

The report by Anderson et al. (1) on metabolites of the tobacco-specific lung carcinogen 4-(methylnitrosoamino)-1-(3-pyridyl)-1-butanone (NNK) in nonsmoking women exposed to environmental tobacco smoke is an important contribution that explains the excess risk for lung cancer in this cohort of women.
Erratum: “Examination of the Safety of Pediatric Vaccine Schedules in a Non-Human Primate Model: Assessments of Neurodevelopment, Learning, and Social Behavior”
Authors: Britni Curtis, Noelle Liberato, Megan Rulien, Kelly Morrisroe, Caroline Kenney, Vernon Yutuc, Clayton Ferrier, C. Nathan Marti, Dorothy Mandell, Thomas M. Burbacher, Gene P. Sackett, Laura Hewitson
Journal: Environmental Health Perspectives (2015)
Women's Health
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Feasibility of robot-assisted radical prostatectomy in high elderly patients: Comparative analysis of the perisurgical/oncological outcomes with younger patients.
Authors: Noriyoshi Miura, Terutaka Noda, Kenichi Nishimura, Tetsuya Fukumoto, Yutaka Yanagihara, Yuki Miyauchi, Tadahiko Kikugawa, Akihiro Oka, Iku Ninomiya, Katsuyoshi Hashine, Takashi Saika
Journal: Journal of Clinical Oncology (2019)

120 Background: Robot-assisted radical prostatectomy (RARP) has become one of standard treatments for localized prostate cancer. However, a feasibility of RARP in high elderly patients has not been clear yet. We performed a comparative analysis of peri-surgical / oncological outcomes for younger and elder patients underwent RARP. Methods: We reviewed and compared our 553 consecutive patients who underwent RARP in 3 institutes from 6/2013 to 2/2018 for peri-surgical outcomes, including surgical times, blood loss, complications, pathological findings, continence recovery, and oncological outcomes stratified by age less than 75 and over 75 years. Results: In our cohort, 477 men were age less than 75 and 76 men were ≥75. Preoperative parameters (PSA, T factor) were similar in both younger and high elder groups. But Gleason score was higher in elder group than younger group ( p=0.009). Operative time (median: 232 vs. 212 minutes) and estimated blood loss (median 100 ml vs 100 ml) were similar in both groups. Two of elder patients (3.8%) needed transfusion. Peri/post-operative all grade complications were 1.4%/6.5% in younger group and 3.8%/9.6% in elder group. No case needed intra-operative open conversion. Surgical positive margin rates were also similar (29.5%, younger vs. 23.7%, elder). Both younger patients (93.6%) and elder patients (90.3%) recovered their continence at 12 months. After a median follow-up of 33.0 months, the 3-year PSA-free survival rates were 86.0% for elder patients and 88.9% for younger patients (p&gt;0.05). Conclusions: In our study, RARP in high elderly patients was relatively safe surgical procedure with a limited complication rate, excellent oncologic and continence outcomes. RARP is feasible even in elderly patients.
A Text-book of the Principles and Practice of Medicine,
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prensa Médica Argentina, Buenos Aires
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
List of Contributors
Journal: JAMA (1982)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A.P.C. as a Cause of Renal Disease
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A systematic assessment of acute viral hepatitis and chronic liver diseases in northeast India with special reference to strengthening of laboratories in the region
Authors: Harpreet Kaur, Vijaya Kumar Karra, Sangit Dutta, Lokeshwar Singh, Kyrshanlang G Lynrah, Tapan Majumdar, Anup Kumar Das, Basumoti Apum, Lalrothuama Lal, T Temsu, Yogesh Verma, Subhash Medhi, Biswajyoti Borkakoty, Provash Chandra Sadhukhan, Vineet Kumar Kamal
Journal: Journal of Hepatology (2020)
SOCIETY NEWS.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Carbon monoxide poisoning
Authors: P. M. Winter
Journal: JAMA (1976)

ACUTE carbon monoxide poisoning accounts for approximately 3,500 accidental or suicidal deaths per year in the United States. Many are preventable by medical management based on physiologic understanding. <h3>Pathophysiology</h3> Carbon monoxide poisoning and its mechanism have been known since Claude Bernard reported in 1857 that this gas caused death by hypoxia, consequent on its reversible combination with hemoglobin.<sup>1</sup>The equilibrium reactions were well described by Haldane in 1895.<sup>2</sup>Excellent reviews are available.<sup>3,4</sup> The effects of CO in concentrations encountered clinically are based entirely on its combination with hemoglobin, displacement of oxygen, and consequent disruption of the O<sub>2</sub>transport system. Carbon monoxide competes with O<sub>2</sub>for binding sites on the hemoglobin molecule, and carboxyhemoglobin (COHb) is without practical function as a carrier of O<sub>2</sub>. Because affinity of CO for hemoglobin is 230 to 270 times as great as that of O<sub>2</sub>, the latter is
The Androgen Receptor Modulates Expression of Genes with Critical Roles in Muscle Development and Function
Authors: Anastasia Wyce, Yuchen Bai, Sunil Nagpal, Catherine C. Thompson
Journal: Endocrine Reviews (2010)

Androgen signaling through the androgen receptor (AR), a ligand-dependent transcription factor within the steroid receptor superfamily, plays an important role in the development and maintenance of many tissues. In muscle, androgens act as anabolic agents that increase both muscle mass and strength; however, a key unanswered question is the mechanism through which AR-mediated gene expression leads to these effects. To gain further insight into the mechanism of AR action in muscle, we identified AR-binding sites in primary human muscle cells using chromatin immunoprecipitation followed by tiling microarray detection. Through this analysis, we identified 32,518 potential AR-binding sites throughout the genome that were enriched upon androgen treatment. Sequence analysis of these regions indicated that approximately 90% possess a consensus androgen response element or half-site. Among the identified AR-binding sites are genes known to be directly regulated by AR, confirming the validity of our methodology. Additionally, we identified a number of novel AR targets, including genes and micro-RNAs implicated in muscle differentiation and function, suggesting a direct role for AR-mediated transcription in muscle development. Intriguingly, binding sequences for the Mef2 family of transcription factors were enriched in the AR-bound regions, and we show that several Mef2c-dependent genes are direct targets of AR, suggesting a functional interaction between Mef2c and AR in skeletal muscle. Our results provide new insights into the mechanisms by which androgens promote muscle growth and validate AR as a potential therapeutic target for sarcopenia, muscle wasting, and other androgen-related muscle disorders.
News from the American Heart Association
Journal: Circulation Research (1973)

Stead has made significant contributions to clinical cardiology through his research accomplishments, his leadership in medical teaching, and through his role in developing leaders in medicine.His research achievements included work on plasma volume, on methods for measuring blood flow, on the uses of sodium nitrate to study circulatory collapse and on the absorption of sulphanilamide as an index of blood flow in the intestines.He developed a micro method for determining the protein content of tissue and utilized the catheterization techniques for studying blood flow of the splanchnic area, the heart, kidney and brain-procedures now used routinely by physicians.Dozens of Dr. Stead's students now hold posts in medical schools as chairmen of medical departments, and as professors of anatomy, psychiatry and pathology.In addition, he has published well over 100 papers on a variety of subjects.Active in work of the American Heart Association for many years, Dr.