tbuckley/cabot-search huggingface dataset:
Corneal Birefringence
Authors: Ronald C. Pruett
Journal: JAMA (1982)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Measles in previously vaccinated children. An epidemiological study
Authors: S. A. Wyll
Journal: JAMA (1971)

Between Jan 20 and March 5, 1970, 47 cases of measles occurred in residents of Scott City, Kan, which had not reported a case of measles since 1966. Spread of measles was demonstrated through four generations, involving 35 elementary-school children, 10 preschoolers, and two high-school students. Fifteen of the 47 patients had a documented history of previous measles vaccination. Based on a measles immunity survey, attack rates by school and vaccination status were calculated; the attack rates in the elementaryschool population, which generated the epidemic, were 2.6 and 30.3 for vaccinated immune and unvaccinated susceptible students, respectively. Based on these rates, measles vaccine was 91.4% effective. The immunity survey also demonstrated that a "herd immunity" level of 89% in the elementary-school population did not prevent propagation of the epidemic.
Viruses Connected with Tumors and Warts
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Harefuah, Tel-Aviv
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Blood pressure in chronic renal failure. Effect of sodium intake and furosemide
Authors: J. M. Ulvila
Journal: JAMA (1972)

Control of hypertension is important in the management of chronic renal failure. Data presented here support the view that hypertension in chronic renal failure develops because many patients must have elevated blood pressure in order to excrete the amounts of sodium usually ingested. The data indicate that there is a wide spectrum with respect to the excretion of sodium by the diseased kidney and those patients who excrete the lowest amount of sodium have the greatest difficulty with control of blood pressure. Attempts to lower blood pressure by restricting sodium in the diet often cause such a marked reduction in sodium excretion that the patient has to reduce dietary sodium intake to an intolerably low level in order to stay in balance. In such patients preliminary experience indicates that furosemide can increase sodium excretion sufficiently to maintain sodium balance on an acceptable diet without an increase in blood pressure.
Prospective study of primary Sjogren syndrome associated to HCV-infected patients: Clinical, immunological, genetical and viral genotype characteristics . CHU Montpellier, France
Journal: Hepatology (1995)

<dm:abstracts xmlns:dm="http://www.elsevier.com/xml/dm/dtd"><ce:abstract xmlns:ce="http://www.elsevier.com/xml/common/dtd" view="all" class="author" id="aep-abstract-id7"><ce:section-title>Publisher Summary</ce:section-title><ce:abstract-sec view="all" id="aep-abstract-sec-id8"><ce:simple-para id="fsabs002" view="all">Cryoglobulinemia is defined as the presence of circulating immunoglobulins (I<ce:inf loc="post">g</ce:inf>) that precipitate at temperatures &lt; 37°C and re-dissolve on re-worming. Such an in vitro phenomenon is detectable in a wide number of chronic infectious and immunological disorders, as well as in some hematological malignancies. This chapter discusses Mixed Cryoglobulinemia (MC) that refers to a distinct clinical syndrome in the absence of other well known systemic or neoplastic disorders. Clinically, MC is characterized by a typical triad—purpura, weakness, arthralgias—and by multisystem organ involvement including chronic hepatitis, membranoproliferative glomeruonephritis (MPGN), peripheral neuropathy, skin ulcers, widespread vasculitis, and less frequently lymphatic and hepatic malignancies. The treatment of MC syndrome is particularly challenging because of its complex etiopathogenesis. For a correct therapeutic approach to hepatitis C virus (HCV)-related MC, one must deal with the concomitance of conflicting conditions: HCV infection, autoimmune, and lymphoproliferative alterations. While asymptomatic patients usually do not need any treatment even in the presence of high levels of cryocrit, patients with mildmoderate symptoms—such as palpable purpura—are particularly sensitive to the smallest variations of daily steroid dosage (1-2 mg).</ce:simple-para></ce:abstract-sec></ce:abstract></dm:abstracts>
Anaesthesia, London
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correspondence
Authors: W. C. Dick, H. Hill, V. Wright, P. H. N. Wood
Journal: Annals of the Rheumatic Diseases (1975)

The Sub-Committee for Research of the Arthritis and Rheumatism Council has recently given moral and finan- cial support to enable a National Case Register of the less common rheumatic diseases to be established and main- tained at a clinical rheumatological centre.The need for such a Register springs from paucity of understanding of rare connective tissue diseases because in most rheumatology units so few cases of any one condition are seen that the acquisition of information and skill in management is often anecdotal.Many rheumatologists, perhaps wisely, refrain from publishing single cases, so unless experience is amalgamated useful knowledge is unlikely to result.The object of the register is to increase knowledge and understanding of the identification, natural history, and management of less common rheumatic diseases by establishing a National Case Register of patients suffering from these diseases.This register would provide a pool ofclinical material suitable for detailed study.Interested clinicians who agree to participate will be asked to record simple identification data on suitable cases.These records will be collected and collated by Dr. Hilary Hill at Stoke Mandeville Hospital, Aylesbury, Bucks., and will form the National Register.
Differences in an Author’s Conflict of Interest Disclosures—Reply
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 4396: Clinical Response to Recombinant Acid α-Glucosidase is Predicted by Cardiac Outcome Measures in Children with Pompe Disease
Authors: Carolyn T Spencer, Jami Levine, Deya Corzo, Steven D Colan, Dionne Graham, Priya S Kishnani, Mark Nicolino, Jennifer Li, Nancy Leslie, Ed Wraith, Hanna Mandel, Wuh-Liang Hwu, Barry J Byrne
Journal: Circulation (2008)

Background : Pompe disease is an autosomal-recessive glycogen storage disease due to deficiency of acid α-glucosidase (GAA). Clinical findings in infantile onset disease are due to glycogen accumulation leading to hypertrophic cardiomyopathy, skeletal myopathy, respiratory failure and death. Enzyme replacement therapy (ERT) with recombinant human GAA (rhGAA; Myozyme®) has been shown to prolong survival in infants. We assessed the hypothesis that myocardial response to rhGAA predicts clinical outcome in Pompe. Methods: Echos during one year of ERT were reviewed from patients enrolled in open label trials of rhGAA (n=38). A standardized echo protocol was used at specific time points (wks 0, 4, 8, 12, 26, 38, 52). A central reader made measurements off-line, blinded to study information. Variables including LV mass, volumes, and ejection fraction (EF) were determined. Clinical outcomes at study-end were analyzed in 2 groups: Group A, alive and free of assisted ventilation (AV) or Group B, died or requiring AV. Z-scores were calculated for all echo variables and median z-scores between outcome groups at wk 0 and wk 52 were compared using median scores tests. Non-linear random effects models were used to examine changes over time. Results: Mean age at first infusion = 10.9±9.8 months (range 1.2 – 43.1). At study onset, 7/38 received AV. At study end, mean time to last infusion = 115±44 weeks with 16/38 in Group A and 22/38 in Group B. For Group A vs. Group B, median z-scores at week 0 for LV mass = 6.11 vs. 7.41, mass to volume ratio (MVR) = 4.5 vs. 8.8, and EF = 0.8 for both groups; p≥ 0.12 for each measure. Median z-scores for the same outcome groups, respectively, at week 52 for LV mass = 0.57 vs. 3.41 (p=0.06), for MVR = 0.48 vs. 3.54 (p=0.001) and EF = −0.6 in both groups. In the subgroup not requiring AV at study onset (n=31), MVR is higher at all times in Group B (p≤ 0.03). Conclusion: rhGAA therapy can prolong life in young patients with Pompe, improving outcome compared to an untreated natural history cohort. Even with ERT, there is significant morbidity and mortality. Diminished myocardial response with persistence of significant LV hypertrophy predicts progression to poor clinical outcomes. These and other predictors are required to fully understand response to ERT in Pompe disease.
More Seabather's Eruption
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
'Alternate channel' approaches seek to limit myocardial damage
Authors: J. Henahan
Journal: JAMA (1984)

Coronary veins are being used as alternate channels in new techniques that seek to limit myocardial damage from coronary occlusions or in connection with cardiac surgery. Some of these new techniques still are undergoing preclinical study. Others already have entered the operating room. Many were discussed in Vienna recently at the First International Symposium on Protection of the Myocardium via the Coronary Sinus. These new approaches through the coronary sinus also might increase the efficacy of pharmacologic agents such as streptokinase, the prostaglandins, mannitol, and antiarrhythmic drugs, several participants indicated. The emphasis on the coronary system reflects a rejuvenation of interest in work carried out by Claude Beck, MD, more than 40 years ago. He attempted to treat myocardial ischemia by creating a shunt between the aorta and the coronary sinus. Although short-term improvements in heart function were seen in about 60% of the 200 patients who underwent Beck's operation,
Error in Byline and Author Contributions
Journal: JAMA Surgery (2014)

Yvain Goudard, MD; Sebastien Gaujoux, MD, PhD; Safi Dokmak, MD; Jérôme Cros, MD, PhD; Anne Couvelard, MD, PhD; Maxime Palazzo, MD; Maxime Ronot, MD; Marie-Pierre Vullierme, MD; Philippe Ruszniewski, MD; Jacques Belghiti, MD; Alain Sauvanet, MD
Pathology
Authors: K. M. Brinkhous
Journal: JAMA (1978)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Use of Mammals As Sentinels for Human Exposure to Toxic Contaminants in the Environment
Authors: Daniel J. O'Brien, John B. Kaneene, Robert H. Poppenga
Journal: Environmental Health Perspectives (1993)

The use of sentinel species shows the potential to bridge the gap between animal-based and human-based environmental health research. With regard to the assessment of environmental contamination, the use of the terms "indicator," "monitor," and "sentinel" has often been confusing and ambiguous. A set of definitions is proposed as a standard to rectify this situation. The advantages of the use of sentinel species are provided, as well as criteria for sentinel selection, based on species characteristics. The recent use of mammals as sentinels for human exposure to toxic environmental contaminants is reviewed. A tabulated review of mammals proposed as indicators or monitors is included, as these may act as a database for the selection of sentinel species for future research efforts. The complexity and subtlety of factors interacting between an organism and its environment make it imperative that one provide a focused definition of what one wants the sentinel to assess and for what particular aspect of human health. Some examples of how sentinels might be selected for particular research questions are provided. While the potential for sentinel use in the field of environmental health is enormous, future investigators need to choose sentinels carefully, based on well-defined research questions, and confine conclusions drawn to the particular problem the sentinel was chosen to assess.
Heart Disease
Authors: Morrison Hodges
Journal: JAMA (1975)

This book is a new addition to the list of encyclopedic cardiovascular texts. It is different from most in that two authors have collaborated to write all but three of the 40 chapters. In the preface, the authors state that "every modern physician and surgeon interested in cardiovascular disease must now have a firm grounding in circulatory physiology." Their aim is to provide a clinical text for the practicing physician, with a simultaneous emphasis on the physiological bases of cardiovascular diseases. To achieve this goal, each chapter was first written by the clinical author (Silber) and then reviewed and revised with the physiologist author (the late Dr Katz, one of the most distinguished cardiac physiologists). This approach seems to have worked well. The first 11 chapters, on the physiology and pathophysiology of heart disease, are clearly the best in the book. The chapters on cellular electrophysiology and cardiac arrhythmias are
An investigator's journey in cardiology
Authors: R. J. Bing
Journal: JAMA (1992)

SUMMING up 60 years in academic medicine, in hospital wards, and in research laboratories is a difficult task: memories and impressions converge and the resonance from past events continually changes. How is one to judge one's past? Many would rate it by honors received, societies elected to, or fortune amassed. I judge my life by the degree of happiness I have received from my work, from my music, and from my family. I have been fortunate in having all my life done what I love most: pursuing the science of medicine and creating music. These have formed the anchor that has given my life stability and a continuous sense of value. <h3>Student Years in Europe</h3> From the beginning of medical school I was interested in science and felt that the purely clinical side was only half the coin, for without a strong emphasis on science, medicine would become stagnant. But
SMILE A WHILE
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal