tbuckley/cabot-search huggingface dataset:
Acta Medica Scandinavica, Stockholm
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Missing the boat on drinking and boating
Authors: J. Howland
Journal: JAMA (1993)

PUBLIC policy has approached drinking and boating as though they are analogous to drinking and driving. Accordingly, recent federal and state laws to prevent drinking and boating have focused solely on alcohol use by the boat operator. Similarly, boating safety campaigns conducted by the alcohol industry have promoted the strategy of the "designated boater," which suggests that passengers are free to drink as much as they like as long as the person driving the boat remains sober. This singular emphasis on the drinking behavior of boat operators, as opposed to all occupants of the boat, may have several sources. First, there are indeed boating fatalities caused by drunken helmsmen crashing their vessels into other boats, rocks, piers, or other objects, as in the recent tragic crash in Florida involving three professional baseball players. While infrequent, these events tend to be more memorable and attract more publicity than the more common
Phase II trial of bevacizumab, gemcitabine, oxaliplatin in patients with metastatic pancreatic adenocarcinoma
Authors: G. P. Kim, A. L. Oberg, N. R. Foster, A. Jaslowski, P. J. Flynn, D. Campbell, E. Hedrick, L. Gray, A. Grothey, S. Alberts
Journal: Journal of Clinical Oncology (2007)

4553 Background: The combinations of gemcitabine and oxaliplatin (GemOx) and bevacizumab and gemcitabine have activity in pancreatic cancer. Based on these observations, the NCCTG initiated a multicenter phase II study to evaluate the combination of an active cytotoxic doublet and a targeted agent to determine whether improvement in 6-month survival in previously untreated patients with metastatic pancreas cancer could be achieved. Methods: Treatment consists of gemcitabine 1000 mg/m 2 IV over 100 minutes and bevacizumab 10 mg/kg IV given on day 1, 15; oxaliplatin 100 mg/m 2 IV is given on day 2, 16, repeated every 28 days. Eligibility includes: no prior chemotherapy, ECOG PS 0–2, bili&lt; 2x UNL, AST&lt; 5x UNL. Pts with stable full dose anticoagulation are eligible. Bevacizumab specific exclusions include no recent stroke, heart attack, embolus, tumor invasion or significant proteinuria. CT scans are obtained every 2 cycles. Treatment continues until disease progression, severe adverse events (AEs), or patient refusal. Results: Eighty-two patients were enrolled from 7/05 to 2/06. Median age was 63 (range: 32 - 86). 24 of 82 (29%) evaluable pts had a maximum grade ≥ 4 AE (at least possibly related to treatment). Grade 4 events included (% of pts): neutropenia (7%), thrombosis (6%), thrombocytopenia (5%), pneumonitis (2%), ischemia-cerebral (1%), abdominal infection (1%), small intestine perforation (1%), and small bowel leak (1%). Three patients died from grade 5 events (1-gastric perforation, 1-cerebral ischemia, 1-multi-organ failure). 80 patients were evaluable for outcome assessment (excludes 2 ineligible cases). Median follow-up was 10.3 months (range: 6.3 - 14.7) in the 19 patients still alive. 6-month survival was 65.0% (95% CI: 53.5% - 75.3%). Median survival was 8.1 months (95% CI: 6.5 - 9.3) and median TTP was 5.7 months (95% CI: 4.4 - 6.4). The confirmed response rate was 11.3% (95% CI: 5.3 - 20.3%) with 1 complete and 8 partial responses. Conclusions: In this multi-centered, cooperative group study, promising efficacy with this three-drug combination was observed especially in regards to six- month and median survival. The observed adverse events are comparable to historical controls although caution should be exercised in light of the three grade 5 events. [Table: see text]
Parotid Gland as a Focus of Metastasis
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Investigation of intermittent claudication.
Journal: BMJ (1968)

Senile Psychiatric Disorders-Postwhere temporary or terminal hospital admission becomes necessary.The geriatrician (or, where the patients physical health had been good, the psychiatrist) will have had previous knowledge of the case and thus be more likely to offer early relief within a rationally conducted health service for the aged.Emergency problems will continue to be unavoidable in the case of socially isolated old people, but these present a small minority even under modern living conditions.
In Utero AAV-Mediated Gene Transfer to Rabbit Pulmonary Epithelium
Authors: Michael P Boyle, Raymond A Enke, Robert J Adams, William B Guggino, Pamela L Zeitlin
Journal: Molecular Therapy (2001)

In utero intra-amniotic administration of adeno-associated virus (AAV) for treatment of cystic fibrosis (CF) has the potential to be an efficient way to target the rapidly dividing undifferentiated cells of the fetal pulmonary epithelium, while simultaneously treating other tissues involved in CF (such as the intestines), but has never before been studied. Intra-amniotic administration of 1×1012 particles of AAV-luciferase vector to 110 fetal rabbits at 24–25 days gestation resulted in transgene expression in amniotic membranes, trachea, and pulmonary epithelium. The highest level of transgene expression was found in amniotic membranes. Transgene expression peaked in the lungs 10 days after vector delivery, decreased at day 17, and was no longer detectable after 24 days. The number of pulmonary cells transduced was approximately 1 in 500 and immunohistochemical analysis showed expression in varying cell types, including alveolar cells. Transgene expression was not detected in fetal rabbit intestines, skin or liver, nor in maternal ovaries or liver. Intra-amniotic administration of AAV does not result in the tissue inflammation and fetal loss previously documented with in utero adenoviral administration, and results in high levels of transgene expression in amniotic membranes with lower levels in fetal pulmonary epithelium.
FAMILY FORM OF CYSTINURIA.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Breast cancer. What the Department of Defense should do with its $210 million
Authors: S. M. Love
Journal: JAMA (1993)

HOW IN the world did the Department of Defense (DOD) end up with $210 million for breast cancer research? In January 1991, women across the United States organized the National Breast Cancer Coalition, one of the most effective medical lobbying groups ever. By the spring of 1992, approximately 600 000 letters urging federal attention to the breast cancer epidemic flooded Capitol Hill. Scientific hearings established the need for additional research dollars, and the DOD became the incidental recipient of "earmarked" or "reprogrammed" money, more than doubling the previous federal funding for breast cancer research. This is just the beginning of the battle. The women and men who care about breast cancer across the country and who fought so hard for this money are very concerned that it be well spent.<sup>1</sup> Last year, the DOD was appropriated $25 million for breast cancer research. Funds were quickly expended for high-technology stereotaxic
Treatment for delayed stress response
Authors: M. Annexton
Journal: JAMA (1978)

A husband dies unexpectedly. His wife makes funeral arrangements, receives comfort from family and friends, and apparently accepts the tragedy. Then one day she realizes she feels emotionally numb, the shock sets in, and she can no longer cope. A man suffers serious injuries when his car collides with another. He recuperates from his physical injuries after extended hospitalization. Then the psychological trauma strikes; coping is impossible. In both cases, the emotional stress response is similar. Patients with such stress response syndromes now are being treated with a modified, brief psychotherapy approach by Mardi Horowitz, MD, and associates at the Langley Porter Institute of the University of California at San Francisco. The goal is to restore psychosocial homeostasis with (if possible) only 12 hours of therapy. In each case the patient is assigned to an interviewer and a therapist. Interviews are audiotaped and videotaped to provide the therapist with insight
Geriatrics
Authors: Aman Nanda
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PARIS
Journal: JAMA (1921)

<h3>International Conference on Epizootic Diseases</h3> Last October, following the appearance of cattle plague in Belgium, the Comité consultatif des épizooties of France requested, at the suggestion of its president, that the various governments be invited to appoint delegates to a conference for the purpose of deciding on the proper measures to be taken to prevent, or at least to check the progress of, epizootic diseases. The minister of agriculture, recognizing the value of the suggestion, submitted it to the ministerial council, by which corresponding action was taken. Invitations were promptly sent to foreign governments with the result that they readily entered into the plan. Forty-two countries, colonies or dominions, besides France, expressed their approval and were represented at the conference. In 1871, exceptional conditions analogous to those of today were the occasion for a conference of like nature. The Austrian government at that time took the initiative with the view
Changes in hepatic lobe volume in biliary tract cancer patients after right portal vein embolization*1
Authors: M NAGINO
Journal: Hepatology (1995)

Changes in lobar volume of the liver and in total hepatic function were studied in 19 patients with biliary tract cancer who underwent right portal vein embolization as preoperative management for extensive liver resection. Computed tomography (CT) was performed to estimate liver volume before and approximately 11 days after embolization. An indocyanine green (ICG) test was performed before and 11 to 13 days after embolization. The calculated volume of the right lobe decreased from 761 ±181 cm3 to 625 ± 110 cm3 11 days after embolization (P < .0001), whereas the volume of the left lobe increased from 420 ±94 cm3 to 555 ±110 cm3 (P < .0001). Thus, portal embolization produced a gain in left lobe volume of 136±62 cm3 and an almost equivalent loss in right lobe volume. The hypertrophy ratio of the left lobe, expressed as percentage of postembolization volume of the left lobe to preembolization size, of the 5 patients with diabetes mellitus (DM) was lower than that of the 14 patients without diabetes (116.7 ±6.3% vs. 140.4 ±18.4%; P < .005). The ICG disappearance rate in 16 patients improved from 0.163 ±0.034 to 0.177 ±0.027 (P < .05). The improvement was especially evident in 9 of 14 postjaundice patients, although the rate decreased slightly in 2 patients without jaundice. We conclude that right portal vein embolization can produce a compensatory hypertrophy of the left lobe within 11 days without seriously affecting hepatic function. In diabetic patients, however, a longer interval between embolization and operation may be needed to achieve sufficient hypertrophy of the left lobe.
Family Medicine: the need for research
Authors: R. E. Rakel
Journal: JAMA (1983)

In this issue ofThe Journal(p 63), Culpepper and Franks have succinctly identified the problems facing research in family medicine in its second decade. Although the federal government has recognized the need for improved primary care, such improvement cannot occur without an equivalent emphasis on research to develop new knowledge and improved skills in this area. Unfortunately, this need occurs at a time when the federal government is reducing its commitment to research and is unlikely to shunt remaining funds away from other areas. If primary care is to be the base for an efficient health care system, however, adequate resources must be devoted to improving the knowledge and developing the skills to do this well. Residency training has improved the quality of care provided by family physicians. We now need to pursue vigorously the expansion of knowledge in family medicine. Federal research funds have traditionally gone to academic
REASSESSMENT OF CARDIAC FUNCTION AND IMPLANTABLE CARDIOVERTER-DEFIBRILLATOR USE AMONG MEDICARE PATIENTS WITH LOW EJECTION FRACTION AFTER MYOCARDIAL INFARCTION
Authors: Sean Pokorney, Amy Leigh Miller, Anita Chen, Laine Thomas, Gregg Fonarow, James de Lemos, Sana Al-Khatib, Eric Peterson, Tracy Wang
Journal: Journal of the American College of Cardiology (2015)
THE SURGICAL TREATMENT OF OLD EMPYEMATA.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE REED MEMORIAL.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
2. Classification and Diagnosis of Diabetes:<i>Standards of Medical Care in Diabetes—2021</i>
Journal: Diabetes Care (2020)

The American Diabetes Association (ADA) "Standards of Medical Care in Diabetes" includes the ADA's current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA Professional Practice Committee, a multidisciplinary expert committee (https://doi.org/10.2337/dc21-SPPC), are responsible for updating the Standards of Care annually, or more frequently as warranted. For a detailed description of ADA standards, statements, and reports, as well as the evidence-grading system for ADA's clinical practice recommendations, please refer to the Standards of Care Introduction (https://doi.org/10.2337/dc21-SINT). Readers who wish to comment on the Standards of Care are invited to do so at professional.diabetes.org/SOC.
Correction
Journal: BMJ (1947)

National Health Service SIR,-I, like many others, feel that the sands are running out in connexion with the nationalization of the medical profession.At the moment all is apparently quiet on the horizon.The Minister of Health is being entertained by certain of the royal medical societies and all is peaceful.But one morning we shall wake up to find the profession in the position of a third-rate Civil Service, and all is lost.The Socialist Medical Society is working quietly but effectively in spreading their propaganda in town and country, and unless we rouse ourselves we shall find ourselves " too late "-as Carlyle remarked, " the two saddest words in the English language."May I suggest, that, as the
Rectal biopsy in patients with Crohn's disease. Normal mucosa on sigmoidoscopic examination
Authors: B. I. Korelitz
Journal: JAMA (1977)

Of 99 patients with Crohn's disease whose rectal segment appeared normal on sigmoidoscopy, there was histologic inflammation in 45% and features characteristic of Crohn's disease in 30% of rectal biopsy specimens. Granulomas were found in 18% of patients, including 13% of those with ileitis, 13% of those with ileocolitis, and 37% of those with colitis. Eleven of the 17 granulomas were small, undemarcated microgranulomas. Rectal biopsy specimens are of value to confirm the diagnosis in Crohn's disease and to determine the state of clinical activity even when the sigmoidoscopic appearance is normal. (<i>JAMA</i>237:2742-2744, 1977)
THE ACTION OF TOXIC SERUMS ON PERIPHERAL NERVES.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal