tbuckley/cabot-search huggingface dataset:
Molecular analysis of hereditary elliptocytosis with reduced protein 4.1 in the French Northern Alps
Authors: S Feddal, G Brunet, L Roda, S Chabanis, N Alloisio, L Morle, MT Ducluzeau, J Marechal, JM Robert, EJ Benz, J Delaunay, F Baklouti
Journal: Blood (1991)
Proliferative Lesions of the Exocrine Pancreas in Male F344/N Rats
Authors: Gary A. Boorman, Scot L. Eustis
Journal: Environmental Health Perspectives (1984)

While the rat pancreas is susceptible to experimental cancer induction, the spontaneous incidence of pancreatic cancer in this species is reported to be very low. However, we observed unusually high incidences of focal acinar hyperplasia and acinar adenoma in vehicle control male F344/N rats of some NCI/NTP 2-year toxicological studies. The vehicle in these studies was corn oil given by gavage. Focal acinar hyperplasia, acinar adenoma, and acinar carcinoma (found rarely) represent a continuous spectrum of proliferative lesions of the exocrine pancreas. While the carcinomas have clear morphological indications of malignancy, the biological behavior of focal acinar hyperplasia and acinar adenoma is not known. Although induction of acinar carcinomas is considered clear evidence of carcinogenicity of a test chemical, significantly increased incidences in treated rats of acinar adenomas but not carcinomas provides some evidence of carcinogenicity. The association of acinar hyperplasia and adenoma with vegetable oil gavage complicates the interpretation when marginally elevated incidences of these lesions are observed in rats administered the test chemical in vegetable oil vehicle. Studies of the biological behavior of exocrine pancreatic lesions in male rats would be helpful in assessing the significance of their presence when found after test compound administration.
Viral Hepatitis and Transplant
Journal: Hepatology (2013)

Background:Cardiac evaluation is an important part of the liver transplantation work up to achieve higher post-transplant survival rates.Identification of Coronary Artery Disease (CAD) among asymptomatic candidates is done by cardiac stress tests & Transthoracic ECHO.Cardiac catheterization is considered to be the gold standard in investigating for the presence and extent of CAD.Methods:We investigated the role of Cardiac Calcium Score (CCS) to predict the presence of CAD among patients with major cardiac risk factors including DM, HTN and smoking.Following IRB approval, medical records of patients evaluated at Johns Hopkins Liver Transplant Program, between 1/1/2011 & 5/1/2013 were retrospectively reviewed.Results:CCS was obtained on 66 patients out of 175, after discussing with consultant cardiologist on the liver transplant team.There were 40 males and 26 females.Mean age was 57.8 ± 0.7 years.Mean MELD was 15.2 ± 6.8.Mean CCS was 379.6 ± 639.8.Cardiac cath was done by a single experienced interventional cardiologist on 16 patients.Four patients had coronary obstruction of <50%, 12 patients had maximum obstruction of ≥50% (range 50-90%).Mean CCS was 750.3 ± 714 in patients with <49% stenosis and 883.8 ± 659.7 in patients with ≥50% stenosis.There was no statistical difference between the groups (P > 0.05).The ROC analysis revealed 91% sensitivity and 50% specificity at cutoff of 243 for the identification of occult CAD.Conclusion:Early identification of CAD is important to be able to achieve better post-transplant outcomes.Currently used Stress tests are known to have a lower sensitivity but a higher specificity.CCS above 250 can be considered to select which patients will benefit from further investigation with a cardiac cath.This may eventually eliminate unnecessary procedures in high risk patients with end stage liver disease.More data is needed to verify these findings.
Annals of Surgery, Philadelphia
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Informed Consent
Authors: S. E. Schonberg
Journal: JAMA (1976)

<h3>To the Editor.—</h3> If Dr Laforet was serious in his suggestion that the solution to the "fiction" of informed consent is increased integrity within the medical community, he should be reminded that the integrity of the physician has nothing whatsoever to do with the probability that a physician will be adjudged a tortfeasor under the present system of handling malpractice claims. It is a well-known fact that under the present faultfinding, adversary system of medicolegal "justice," the malpractice noose tightens around the necks of the most competent and honorable physicians in an arbitrary fashion right alongside those physicians who are indeed of a less wholesome character. Therefore, even if all physicians were as ethical as Dr Laforet might desire, the "fiction" would still be a prevalent problem in the malpractice arena as it now exists. Dr Laforet apparently reacted adversely to the use of informed consent forms that "spell out,
The Cover
Authors: Julie S. Berkowitz
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Allergy abstracts
Authors: David Stein S&v-N, Harold Friedman, Ohio Monroe, Coleman Stamford, Conn Eugene, Walzer Bridgeport, Cowi Sheldon Berger Freehold, N Jeremiah, Stein Cleveland, Bert Kahn, Tex Andre, J Codispoti Suffern, N Robert, Y Lin, New York
Journal: Journal of Allergy and Clinical Immunology (1987)
Face Agnosia And The Neural Substrates Of Memory
Authors: A. Damasio
Journal: Annual Review of Neuroscience (1990)

The brain's default mode network consists of discrete, bilateral and symmetrical cortical areas, in the medial and lateral parietal, medial prefrontal, and medial and lateral temporal cortices of the human, nonhuman primate, cat, and rodent brains. Its ...Read More
Gonococcal Arthritis
Authors: MARK G. PERLROTH
Journal: Annals of Internal Medicine (1970)

Letters and Comments1 December 1970Gonococcal ArthritisMARK G. PERLROTH, M.D.MARK G. PERLROTH, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-73-6-1046_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: It has taken me some time to crystallize my dissatisfaction with the article by Dr. Allan Metzger, describing his care of a patient with gonococcal arthritis complicating gonorrheal pharyngitis (Ann Intern Med 73:267-269, 1970). I have no quarrel with Dr. Metzger's careful history and physical examination, nor with his laboratory diagnosis of this patient.What I am troubled by is the time course between the events of the patient's admission workup, the bacteriologic diagnosis ofNeisseria gonorrhoeaeinfection, and the beginning of specific therapy. If we accept that the culture returned positive 48 hr after admission, the... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Medicine Stanford University School of Medicine Stanford, Calif. 94305 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1970Volume 73, Issue 6Page: 1046-1047KeywordsArthritisGonorrheaPatientsPharyngitisResearch laboratories Issue Published: 1 December 1970 PDF DownloadLoading ...
Progress Toward Global Poliomyelitis Eradication, 1985-1994
Journal: JAMA (1995)

In 1988, the World Health Assembly resolved to eradicate poliomyelitis globally by 2000 (1). Substantial progress toward this goal has been reported from all six World Health Organization (WHO) regions; 20 countries reported poliovirus transmission in December 2000 compared with 30 in 1999. WHO has prepared a global action plan that anticipates certification of polio eradication in 2005 (2). This report summarizes the status of the eradication effort and describes the remaining tasks to be completed to reach global polio eradication
Scientific Abstracts
Journal: Clinical Nuclear Medicine (2003)

Log in or Register Subscribe to journalSubscribe Get new issue alertsGet alerts Enter your Email address: Wolters Kluwer Health may email you for journal alerts and information, but is committed to maintaining your privacy and will not share your personal information without your express consent. For more information, please refer to our Privacy Policy. Subscribe to eTOC Secondary Logo Journal Logo All Articles Images Videos Podcasts Blogs Advanced Search Toggle navigation Subscribe Register Login Articles & Issues Current IssuePrevious IssuesPublished Online First Collections ACNM MeetingsCMECommunication in OrganizationCOVID-19Feedback and RewardsFrom the American College of Nuclear MedicineHighly Cited and Frequently Read ArticlesPlanning and Conducting Meetings EffectivelyQuality and Safety in Health CareRecruitment of New PhysiciansTips for Giving a Memorable PresentationTips for LeadersTips for Physicians in Getting the Right Job ACNM ArticlesACNM Website For Authors Submit a ManuscriptInformation for AuthorsLanguage Editing ServicesAuthor Permissions Journal Info About the JournalEditorial BoardAdvertisingOpen AccessSubscription ServicesReprintsRights and Permissions All Articles Images Videos Podcasts Blogs Advanced Search
What goes up must come down, but hypertension experts worldwide differ about ways, means
Authors: M. F. Goldsmith
Journal: JAMA (1990)

BLOOD PRESSURE levels that make an American physician write a prescription may elicit only advice about life-style in Switzerland. Most Australians know of the need for medical assessment of individual risk factors for cardiovascular disease, while millions of Brazilians are so unaware of potential health problems that malignant hypertension, which has nearly disappeared in the industrialized world, remains a real threat in that country. These variations and others emerged in a special panel discussion among experts from seven nations who assembled in Baltimore, Md, for the American Heart Association's (AHA) 44th annual fall conference and scientific sessions of its Council for High Blood Pressure Research. The other countries represented were Britain, Japan, and West Germany. Although national policy details may not be the same, said Stevo Julius, MD, professor of medicine and physiology, University of Michigan, Ann Arbor, smiling wryly, "one thing is no different. Hypertension is a disease treated
Heart Affections, Their Recognition and Treatment.
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nitropyrene: DNA Binding and Adduct Formation in Respiratory Tissues
Authors: M. A. Jackson, L. C. King, L. M. Ball, S. Ghayourmanesh, A. M. Jeffrey, J. Lewtas
Journal: Environmental Health Perspectives (1985)

Binding of 1-nitro (14C)pyrene (NP) or its metabolites to cellular DNA and protein in cultures of rabbit alveolar macrophages, lung tissue, and tracheal tissue was examined. DNA binding in tracheal tissue (136 +/- 18.3 pmole NP/mg DNA) was four to five times the levels measured in either lung tissue (38 +/- 9.4 pmole NP/mg DNA) or macrophages (26 +/- 7.5 pmole NP/mg DNA). Adduct analysis of DNA isolated from lung tissue incubated with 1-nitro[H3]pyrene in vitro resulted in the identification of 2 to 5% of the NP adducts as C8-deoxyguanosine 1-aminopyrene. NP was also bound to cellular protein in tracheal tissue and lung tissue, and at a lower level in macrophages. Cocultivation of the macrophages with lung and tracheal tissue decreased the DNA binding in tracheal tissue by 45%. Following intratracheal instillation of diesel particles (5 mg) vapor-coated with 14C-NP (380 ppm, 0.085 muCi/mg) particles into rats, 5-8% of the radioactivity remained in the lungs after 20 hr. Most of the diesel particles were also deposited in the lung. Examination of DNA and protein binding in this tissue showed 5 to 12% of the pulmonary 14C bound to protein and no detectable levels of 14C bound to DNA.
Allograft rejection in pediatric recipients of living related liver transplants
Authors: E ALONSO
Journal: Hepatology (1996)

The purpose of this study was to compare the inci-dence and severity of rejection episodes in a group of dence and severity of rejection episodes in a group of children receiving living related orthotopic liver transchildren receiving living related orthotopic liver transplants (LRLT) versus patients receiving cadaveric liver plants (LRLT) versus children receiving cadaveric liver transplants (CLT). transplants (CLT). Thirty-eight patients received pri-PATIENTS AND METHODS mary LRLT and 54 patients received CLT during a 3-year period ending June 1993. Baseline immunosuppressionThe study population included all pediatric patients underconsisted of cyclosporin, azathioprine, and corticostegoing primary orthotopic liver transplantation at the Univerroids.Rejection episodes were confirmed by liver histolsity of Chicago during a 3-year period beginning June 1990.ogy and were treated initially with pulse intravenous Patients were divided into two groups: those receiving their methylprednisolone, 10 mg/kg/d for 3 days.Steroid-resisfirst liver transplant from a cadaveric donor (CLT), and those tant rejection was treated with OKT3 or FK506.The mereceiving their first graft from a living related donor (LRLT).dian patient ages were 1.3 years for the CLT and .8years Patients who died or required a second transplantation durfor the LRLT recipients.Acute cellular rejection develing the first 7 postoperative days were excluded from the oped in 78% of the CLT grafts and 74% of the LRLT grafts study groups.Patients were also excluded if they were partic-(P Å ns).However, steroid-resistant rejection was signifiipating in an experimental protocol studying primary immucantly less frequent in the LRLT recipients, 13% versus nosuppression with FK506, although evaluation of data with 43% in the CLT recipients (P õ .01).Ductopenic rejection the inclusion of this cohort of patients yielded similar results.was diagnosed in 20% of CLT and 8% of LRLT grafts (P All patients had regular evaluation from the time of transõ .10),and graft loss caused by rejection was 9% in the plantation, which resulted in a follow-up period of 12 to 48 CLT and 3% in the LRLT group (P Å ns).In conclusion, months.Evaluation for clinical or biochemical evidence of the overall incidence of rejection is the same in LRLT rejection was performed at least monthly for the first 6 and CLT recipients, but LRLT recipients are less likely months after transplantation and then at least every 3 than CLT recipients to develop steroid-resistant rejecmonths for 1 year.Patients who were 18 months posttranstion or ductopenic rejection.(HEPATOLOGY 1996;23:40plantation were evaluated at 6-month intervals if there had 43.) been no rejection in the preceding observation period.Data were collected by retrospective chart review and included episodes of rejection, immunosuppressive therapy, to .3 mg/kg/d by the twenty-eighth postoperative day; and transplants; MHC, major histocompatibility complex.azathioprine 1 mg/kg/d. 9,10Six months posttransplantation,
Sporadic Jakob-Creutzfeldt Disease Presenting as Primary Progressive Aphasia
Authors: David Y. Johnson, Diana L. Dunkelberger, Maya Henry, Aissatou Haman, Michael D. Greicius, Katherine Wong, Stephen J. DeArmond, Bruce L. Miller, Maria Luisa Gorno-Tempini, Michael D. Geschwind
Journal: JAMA Neurology (2012)

Objective: To report the clinical, neuropsychological, linguistic, imaging, and neuropathological features of a unique case of sporadic Jakob-Creutzfeldt disease in which the patient presented with a logopenic variant of primary progressive aphasia.Design: Case report.Setting:
Disulfiram hypersensitivity and rubber contact dermatitis
Authors: P. K. Webb
Journal: JAMA (1979)

DISULFIRAM is a valuable adjunct in the outpatient therapy of ethanol abuse. Persons taking maintenance doses of disulfiram avoid alcohol, as ingestion causes unpleasant symptoms such as flushing, dyspnea, headache, and vomiting. The danger of a severe reaction with tachycardia and hypotension has received much publicity and is minimized by lower disulfiram doses, abandonment of intentional challenge with ethanol, and careful screening of candidates for cardiopulmonary disability. It is little recognized that screening should also seek a history of rubber contact sensitivity. No such precaution is noted in the disulfiram prescribing information. This case illustrates the dangers of administering disulfiram to a patient with this history. <h3>Report of a Case</h3> A 32-year-old white male bartender requested disulfiram therapy as an aid to resist the temptation to drink at his job. He was otherwise well, with no history of major illnesses, and had abstained from alcohol for one week. A screening
Is there still too much extrapolation from data on middle-aged white men?
Authors: P. Cotton
Journal: JAMA (1990)

A MYOPIC VIEW of confounding factors in clinical research is continuing to confound clinical practice. Efforts to streamline studies by using the most homogeneous population possible have filled medical libraries with data on middle-aged white men. Even female rats are commonly excluded from basic research. In the real world this leaves physicians to guess whether new findings can be extrapolated to the rest of their patients. For instance, no one knows if aspirin has any prophylactic value in coronary artery disease in women because virtually all the current evidence is from studies on men. And for most classes of drugs, no one knows if ethnic variations in drug metabolism exist, or where they have been seen, as with β-blockers and antidepressants, what the full extent of their clinical relevance might be. These gaps remain despite documentation of important differences in drug responses and risk profiles among women, the elderly, and
Acute purulent otitis media in children older than 5 years. Incidence of Haemophilus as a causative organism
Authors: R. Schwartz
Journal: JAMA (1977)

It is generally believed that<i>Haemophilus influenzae</i>is not commonly a causative agent of otitis media in children older than 5 years of age. We recently studied cases of 58 children, aged from 5 to 9 years, who had acute otitis media.<i>Haemophilus species</i>were the causative agents in 36% of cases. This high incidence of<i>Haemophilus isolation</i>from the middle ear exudate of these children has important therapeutic implications; antibiotics effective against<i>H influenzae</i>should be employed when dealing with otitis media in this older age group. (<i>JAMA</i>238:1032-1033, 1977)
Acute adrenal insufficiency
Authors: T. Himathongkam
Journal: JAMA (1974)

ACUTE adrenal insufficiency or "Addisonian crisis" is a life-threatening event in a patient whose physiological requirement for glucocorticoid and mineralocorticoid steroid hormones exceeds available supply. Prior to the availability of steroid therapy, acute adrenal insufficiency was the culmination of end-stage Addison disease. With an increasing use of maintenance glucocorticoid therapy, acute adrenal insufficiency has become more commonly recognized among patients with bilateral adrenalectomy, hypophysectomy, and in those on long-term glucocorticoid therapy for other disease processes. Precipitating events are various stressful situations—surgery, severe infection, and trauma—where the requirement for corticosteroids is increased and not met by the fixed steroid dosage that the patient is taking. Acute adrenal insufficiency is generally characterized by one or more of the following signs and symptoms<sup>1,2</sup>: (1) hypotension, (2) nausea and vomiting, (3) severe weakness, (4) hyperthermia, (5) hypoglycemia, and (6) hyponatremia and hyperkalemia. In addition, the intravascular volume depletion secondary to mineralocorticoid deficiency may
A metered way of life
Authors: The Lancet
Journal: The Lancet (1999)

Napoleon Bonaparte did not think much of the metre, while at around the same time early US presidents were singing the praises of the metric system. Yet France has long been metric while the USA admits to being the only country in the industrialised world that has not gone metric officially, and, if anything is slipping backwards. We read of signposts on American roads being repainted in miles as enthusiasm for the kilometre wanes, while local building regulations return to feet and inches. In science, SI (Système International d'Unités), which is just the modern version of the metric system, is well established but in medicine a liking for "conventional units" has persisted.