tbuckley/cabot-search huggingface dataset:
Bioequivalence of Levothyroxine Preparations: Issues of Science, Publication, and Advertising
Authors: E. Chester Ridgway
Journal: JAMA (1997)

<h3>To the Editor.</h3> —The study by Dr Dong and colleagues<sup>1</sup>confirms clinical experience that generic and brand-name levothyroxine preparations may be used for treating hypothyroidism. However, another important issue is whether substitution of 1 thyroxine preparation for another results in clinically significant changes in thyroid status. Based on a sophisticated statistical analysis that relies exclusively on comparing mean serum hormone levels, the authors conclude that the 4 thyroxine preparations tested "are interchangeable in the majority of patients." Given that serum thyrotropin levels provide the most accurate assessment of thyroid status, and that this parameter is used by virtually all clinicians to adjust thyroxine therapy, it is unfortunate that the authors did not provide the thyrotropin levels for individual patients in their study. These unpublished data have recently been released into the public domain,<sup>2</sup>and they raise serious concerns about the conclusions and recommendations advanced by these investigators. Of the 24 thyroxine-treated
EDITORIAL
Authors: W. N. Dodds
Journal: British Journal of Sports Medicine (1986)

Varied topics are featured in this issue, again illustrating the broad spectrum encompassed by sports medicine.The papers on upper limb injuries in rock climbing and the case report of pancreatic trauma during karate, stress the importance of careful history taking and physical examination.When this is overlooked there is likely to be delay in diagnosis and hence, treatment.This point is again emphasised in the correspondence concerning pneumothorax in a soccer player.
From the Centers for Disease Control. Recommendations for preventing transmission of human immunodeficiency virus, hepatitis B virus to patients during exposure-prone invasive procedures
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
African Trypanosomiasis
Authors: Judy A Streit, Eiyu Matsumoto
Journal: New England Journal of Medicine (2016)

A previously healthy 60-year-old woman presented with fevers, chills, myalgias, headache, and two pruritic areas on her back. She had returned 3 days earlier from a 2-week trip to Botswana and Zimbabwe that had included canoeing and camping.
Epidemic Poliomyelitis
Authors: Harry M. Weaver
Journal: New England Journal of Medicine (1950)

ALTHOUGH human poliomyelitis was first described in 1789,1 anthropologic studies indicate that this disease has afflicted mankind since antiquity.2 In endemic form, it has been reported from most parts of the world, but in a number of different geographic areas there has been a transition from an endemic disease to one of epidemic character. This transition occurred first in Scandinavia in the 1870's, in Europe in the 1880's, in the northern United States and Australia in the 1890's, in New Zealand in the 1920's, in the southern United States in the 1930's, in the large metropolitan areas of Japan (Osaka . . .
Pertussis Vaccine Injury
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Parathyroid hormone inhibits renal phosphate transport by phosphorylation of serine 77 of sodium-hydrogen exchanger regulatory factor–1
Authors: Edward J. Weinman, Rajat S. Biswas, Quihong Peng, Lily Shen, Christina L. Turner, Xiaofei E, Deborah Steplock, Shirish Shenolikar, Rochelle Cunningham
Journal: Journal of Clinical Investigation (2013)
Mammography
Authors: Arthur I. Holleb
Journal: JAMA (1986)

<h3>To the Editor.—</h3> I offer a word of caution about the COMMENTARY, "A Word of Caution Concerning Mammography."1 James F. Newsome and Robert McLelland are concerned that physicians using mammography as a diagnostic procedure in symptomatic women might use a negative result as justification for not doing a biopsy. Such a circumstance would certainly be cause for concern, and, in fact, it was of sufficient concern to make clear the distinction between detection and diagnosis, and between asymptomatic and symptomatic women, that prompted the American Cancer Society to write, in its original statement on mammography in 1982<sup>2</sup>: Since the symptomatic women with a dominant mass or persistent discomfort, nipple discharge, or other symptoms and findings may have breast cancer, all such women should have a thorough breast examination including mammography and any other diagnostic study needed to determine if cancer is present....<i>Physicians must be aware of the limitations</i>
Theatrum Instrumentorum
Authors: Stephen J. Lurie
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
White Matter Abnormalities in First-Episode, Treatment-Naive Young Adults With Major Depressive Disorder
Authors: Ning Ma
Journal: American Journal of Psychiatry (2007)

Objective: The aim of this study was to explore the microstructural integrity of whole-brain white matter by diffusion tensor imaging in first-episode, treatment-naive young adults with major depressive disorder. Method: Diffusion tensor imaging scans were obtained from 14 first-episode, treatment-naive young adult patients with major depressive disorder and 14 healthy comparison subjects. A voxel-based method was used to analyze the scans. Results: The patient group exhibited significantly lower fractional anisotropy values than healthy comparison subjects in the white matter of the right middle frontal gyrus, the left lateral occipitotemporal gyrus, and the subgyral and angular gyri of the right parietal lobe. There were no regions of significantly higher fractional anisotropy values in patients compared with healthy comparison subjects. Conclusions: These findings suggest that abnormalities of brain white matter may be present early in the course of major depressive disorder. They also support the idea that white matter lesions may disrupt the neural circuits involved in mood regulation and thus contribute to the neuropathology of major depressive disorder.
Myocarditis
Authors: CLARENCE E. DE LA CHAPELLE, CHARLES E. KOSSMANN
Journal: Circulation (1954)

A review of selected papers on myocarditis published during the past decade and an analysis of some original data together with personal experiences have been presented. All of these indicate that the clinical diagnosis of myocarditis is made far too infrequently as contrasted with the high incidence of this disease as recognized by pathologists. It is estimated that approximately 10 per cent of all patients coming to necropsy will demonstrate some evidence of myocarditis. The discrepancy between the clinical and the pathologic incidences can possibly be ascribed to two factors, namely, (a) the relatively innocent nature of the clinical and laboratory findings in many cases, and (b) the apparent reluctance of the clinician to make the diagnosis. It is likely that a correct diagnosis of myocarditis will be made more often and cardiac catastrophies avoided if the clinician will consider the possibility of the diagnosis, particularly in the course of all types of infectious diseases.
Physical Diagnosis
Authors: Jack Coulehan
Journal: Annals of Internal Medicine (2014)

Ad Libitum15 July 2014Physical DiagnosisJack Coulehan, MD, MPHJack Coulehan, MD, MPHFrom Setauket, New York.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M14-0149 Audio Reading - “Physical Diagnosis” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Physical Diagnosis," by J. Coulehan. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail InspectionWe snap on both lights and shake himuntil he wakes. To get a good look,we make him flip to the prone positionand untie his gown. Amazing! Well-worththe extra trip. His lesions blanketthe upper back like thousands of fish eggsin a salmon-colored cloud. Among themare jagged claws of excoriations—he can't stop scratching. Even drugsdon't calm him down. His only comfortis sleep. Sleep and studio wrestling.to ignore us grimaces when ... Author, Article, and Disclosure InformationAffiliations: From Setauket, New York.Current Author Address: Jack Coulehan, MD, MPH, e-mail, John.[email protected]edu. PreviousarticleNextarticle Advertisement Audio Reading - “Physical Diagnosis” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Physical Diagnosis," by J. Coulehan. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics Cited byToward a Renascence of Physical Diagnosis in the Intensive Care Unit 15 July 2014Volume 161, Issue 2Page: 160KeywordsBatsDrugsHearingHeartInflammationLesionsScarsSleepSpleenSystolic ejection murmur ePublished: 15 July 2014 Issue Published: 15 July 2014 Copyright & PermissionsCopyright © 2014 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
JAMA reference directories
Journal: JAMA (1977)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Zen Macrobiotic Diets
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Flow System for Automated Analysis of Maize Pollen
Authors: Etsuo Amano
Journal: Environmental Health Perspectives (1981)

Pollen grains are haploid gametes of uniform shape and size, and can be obtained in large quantity. If appropriate traits are used, they can be an excellent material for investigation of rare but important biological events like intracistronic recombinations or mutations induced by very low level of mutagens. This advantage will be further improved, if the laborious counting and examination can be made automatically. For automation of pollen analysis, techniques of flow analysis and image analysis would be applicable. Flow analysis with a optical detector was tested using maize pollen. Pollen grains were transported by gentle suction through a glass capillary which was placed under a microscope. Interruptions of the light path by pollen grains were detected by a silicon photocell after optical magnification and converted into electric pulses. The frequency distribution of pulse height was examined by a multichannel pulse height analyzer. 10(6) pollen grains would be counted and classified within about 30 min for a pollen suspension dilute enough for separation of each pulse. The flow system tested seems promising for detection of Wx mutant pollen in a wx pollen population after iodine staining if illumination of sample particles is improved.
LAMINECTOMY.
Authors: JOHN C. MUNRO
Journal: JAMA (1900)

The following cases of laminectomy, eighteen operations on seventeen patients are reported in the hope that they may furnish some encouragement for interference in one of the most interesting if discouraging fields for surgical operation, and because the writer is convinced that by a simplification of the technique the operation risk is much lessened, and that in the midst of numerous failures, so far as the power of giving life is concerned, occasionally a brilliant success is possible, while in certain other conditions, relief of suffering and prolongation of life is sure to follow. Furthermore, instead of the field for operation becoming narrower, there is every reason to believe that new and untried conditions may be amenable to surgical interference. For most complete and invaluable neurologic data, the writer is indebted, in twelve of the cases, to Dr. William N. Bullard, whose interest and judgment have ever been most helpful
Childhood Asthma and Steroid Therapy as Influences on Growth
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Life After Breast Cancer
Authors: Hester Hill Schnipper
Journal: Journal of Clinical Oncology (2001)

Article Tools THE ART OF ONCOLOGY: WHEN THE TUMOR IS NOT THE TARGET Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2001.19.15.3581 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 11481368 Life After Breast Cancer Hester Hill SchnipperxHester Hill SchnipperSearch for articles by this author Show More From the Beth Israel Deaconess Medical Center, Boston, MA https://doi.org/10.1200/JCO.2001.19.15.3581 First Page Full Text PDF Figures and Tables © 2001 by American Society of Clinical Oncology
PWE-062 Long-term infection of<i>Helicobacter pylori</i>48GX, and output strains 12.2 and 12.3, results in hypergastrinaemia, gastric carcinoids and dysplasia in Mongolian gerbils
Authors: C Duval, K Bransfield, M M Walker, A Varro, P A Robinson, J E Crabtree
Journal: Gut (2010)

<h3>Introduction</h3> <i>H pylori cagA</i><sup>+</sup> 48GX strain with a functional <i>cag</i> PAI was isolated from a patient in Guangxi Province, PRC, an area of high incidence of gastric cancer. Inoculation of 48GX into gerbils for 4 weeks resulted in recovery of 12.2 and 12.3 output strains from two gerbils, with RAPD profiles and <i>glmM</i> sequence identical to 48GX, and variable ability to activate IL-8 transcription in gastric epithelial cells. The aims of the study were to recover output strains from gerbils inoculated with 12.3 to evaluate stability of <i>cag</i> PAI function, and to examine the effects of long-term infection with 12.2 and 12.3 on pathology. <h3>Methods</h3> Male Mongolian gerbils were orally infected with either 12.2 or 12.3 output strains. Gerbils colonised with strain 12.3 were sacrificed at 6 and 21 weeks to recover output strains. At 60 weeks post-infection 12.2 and 12.3 infected gerbils and controls were sacrificed. Gastric tissue was taken for pathology. Plasma gastrin was measured by radioimmunoassay. Ability of strains to induce IL-8 transcription was determined by an IL-8 reporter assay in L5F11 epithelial cells. <h3>Results</h3> Six week isolates (41.1 and 41.11) from two gerbils infected with strain 12.3 induced lower IL-8 transcription than the input strain. In contrast, 21-week isolates (36.1–36.9) showed variability in inducing IL-8 transcription: four stimulated IL-8 transcription equivalent to, or greater than, the parent strain, whereas five had minimal, or reduced, IL-8 transcription relative to 12.3 input strain. At 60 weeks, gross morphological changes and increased mucosal thickness were evident in 12.2 and 12.3 infected gerbils compared to controls. Infection with 12.2 and 12.3 increased plasma gastrin (p&lt;0.001) relative to uninfected gerbils (142.7+15.7 and 117.3+12.6 vs 18+3.17 pM, respectively). Infection with both strains was associated with extensive intramucosal and submucosal inflammation, mucous metaplasia, cystic and foveolar hyperplasia. Gastric carcinoids were evident in two gerbils with hypergastrinaemia, infected with 12.2 (gastrin 194 pM), and 12.3 (gastrin 168 pM) strains. Dysplasia was evident in 4/12 and 5/12 gerbils infected with 12.2 and 12.3 strains, respectively. Overall 11/25 (44%) of gerbils infected with 48GX output strains had gastric dysplasia or carcinoids at 60 weeks post-infection. <h3>Conclusion</h3> These studies identify a new gerbil colonising <i>cag</i> PAI+ <i>H pylori</i> strain which induces severe pathology. They also demonstrate the functional instability of the <i>cag</i> PAI in vivo in the gerbil model, and provide multiple output strains for analysis of in vivo genomic modifications in <i>H pylori</i>.
Pruning an old root: premedical science and medical school
Authors: E. D. Pellegrino
Journal: JAMA (1980)

If there is anything harder than planting a new idea, it is uprooting an old one. Everyone shrinks from the periodic pruning that old ideas demand if they are to remain healthy. To evict an old idea is to precipitate a panic of identity. What, then, must be our response to the study by Dickman and associates elsewhere in this issue (p 2506)? They challenge one of the most cherished notions of medical educators—the indispensability of college preparation in science for perform. ance in medical school and, implicitly, for practice as well. Indeed, they show that nonscience majors do as well as, and in some instances better than, science majors during both the basic and clinical years and that they choose the same specialties later on. These conclusions will be heretical to many educators. The idea that medicine is synonymous with science is so inextricably insinuated into their minds that