tbuckley/cabot-search huggingface dataset:
Effect of octreotide on endogenous vasoactive systems and renal function in cirrhotic patients with ascites . Department of Gastroenterology, Hospital de la SAnta Cr�u i Sant Pau, *Neurochemistry Laboratory, CSIC, Barcelona, Spain
Journal: Hepatology (1995)

A rapid and simple method based on immunoaffinity extraction, stable isotope dilution and gas chromatography—mass spectrometry has been developed for profiling urinary metabolites of prostacyclin and thromboxane. 6-Ketoprostaglandin F1α (6-keto-PGF1α), 2,3-dinor-6-ketoprostaglandin F1α (2,3-dinor-6-keto-PGF1α), thromboxane B2 (TXB2) and 2,3-dinor-thromboxane B2 (2,3-dinor-TXB2) were quantitatively extracted from human or rat urine spiked with deuterated internal standards using mixed-bed columns containing immobilized anti-6-keto-PGF1α and anti-TXB2 antibodies (cross-reacting with 2,3-dinor-6-keto-PGF1α and 2,3-dinor-TXB2, respectively). The extract was directly derivatized to form pentafluorobenzyl ester, methyloxime, trimethylsilyl ether derivatives. Quantitation was performed by stable isotope dilution assay and high-resolution gas chromatography-negative ion chemical ionization mass spectrometry, by monitoring the carboxylate anions (M — 181) of the derivatized metabolites. The method was applied to evaluate the urinary excretion of 6-keto PGF1α, 2,3-dinor-6-keto-PGF1α, TXB2 and 2,3-dinor-TXB2 in humans and rats. Results were in accordance with previously reported data obtained by other methods. Novel data on the urinary excretion of 2,3-dinor-6-keto-PGF1α in rats under basal conditions are presented. This sensitive and selective method represents a significant advance in terms of rapidity and simplicity over other immunoaffinity—gas chromatography-mass spectrometry methods for measuring single prostanoids, such as 6-keto-PGF1α or TXB2, since it allows profiling of a group of metabolites whose balance is important in several physiopathological conditions.
The Religio-Medical Masquerade.
Journal: JAMA (1910)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Omitted Statistical Analysis Description and Errors in Figure
Authors: Eric Leppink, Samuel Chamberlain, Jon Grant
Journal: JAMA Psychiatry (2016)

Clemens W. Janssen, PhD; Christopher A. Lowry, PhD; Matthias R. Mehl, PhD; John J. B. Allen, PhD; Kimberly L. Kelly, MPA; Danielle E. Gartner, BA; Angelica Medrano, BA; Tommy K. Begay, PhD; Kelly Rentscher, MA; Joshua J. White, BS; Andrew Fridman, BS; Levi J. Roberts, BA; Megan L. Robbins, PhD; Kay-u Hanusch, MSc; Steven P. Cole, PhD; Charles L. Raison, MD
Candidiasis: colonization vs infection
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medical Economics
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
White Fingers
Journal: JAMA (1971)

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The public Service.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hypoglycemia from IGF2 Overexpression Associated with Activation of Fetal Promoters and Loss of Imprinting in a Metastatic Hemangiopericytoma
Authors: Elizabeth A. Lawson, Xun Zhang, Jonathan T. Crocker, Wei-Lien Wang, Anne Klibanski
Journal: Endocrine Reviews (2009)

ABSTRACT Context The mechanism of IGF2 overexpression in non-islet-cell tumor hypoglycemia is not understood. Objective We investigated the imprinting control and promoter usage for IGF2 expression to identify a mechanism for increased IGF-II production in non-islet-cell tumor hypoglycemia. Patient and Methods A patient with metastatic hemangiopericytoma was studied. Tissue from the original hemangiopericytoma, metastatic tumor, and uninvolved liver was analyzed for IGF-II immunohistochemistry. IGF2, a paternally imprinted gene, shares a control region with maternally imprinted H19, a putative tumor suppressor. IGF-II and H19 mRNA expression was compared in metastatic tumor and uninvolved liver by quantitative RT-PCR. Imprinting of IGF2/H19 genes and IGF2 promoter usage in metastatic tumor was investigated by RT-PCR and sequence analysis, and the methylation pattern in the IGF2/H19 imprinting control region was analyzed. Results IGF-II protein expression was increased in metastatic tumor vs. uninvolved liver and original tumor. In the metastatic tumor, IGF-II mRNA was increased 60-fold, but H19 mRNA was comparable to uninvolved liver; loss of imprinting of IGF2, but not H19, was identified; no major change in methylation of the IGF2/H19 imprinting control regions was observed; and transcripts from four different IGF2 promoters were detected, compared to two in uninvolved liver. Conclusions IGF-2 overexpression, newly acquired in the metastatic tumor, was associated with loss of IGF2 gene imprinting and different promoter usage. The imprinting control mechanism governing the IGF2/H19 locus was intact, as evidenced by normal levels of H19, maintenance of H19 imprinting, and no major change in methylation of the imprinting control regions.
Blood pressure and calcium supplementation
Authors: F. P. Cappuccio
Journal: JAMA (1987)

<h3>To the Editor.—</h3> Given the controversy over possible effects of calcium supplementation on high blood pressure,<sup>1-4</sup>rigorously designed and carefully presented studies are needed to answer such a basic question as whether oral calcium does or does not lower high blood pressure. In this regard, we wish to comment on the article by Lyle et al.<sup>5</sup> The authors' choice of a normotensive population, with an average baseline blood pressure below 120/75 mm Hg, does not appear to be appropriate for providing the answer to this question, despite the finding of "statistically significant" falls in blood pressure of 2.3 to 2.8 mm Hg. Furthermore, the presentation of the data is puzzling: since the placebo and calcium groups within each racial group were comparable in terms of blood pressure, age, body weight, and plasma and urinary variables, the need for adjusting the data on blood pressure, urinary variables, and even
Technological imperatives and paradoxes
Authors: S. B. Sheps
Journal: JAMA (1988)

That concepts and techniques for the assessment of diagnostic technologies have been well described since Yerushalmy's article<sup>1</sup>about total body roentgenography<sup>2-4</sup>and that these concepts and techniques seem to have had relatively little influence on the diffusion of diagnostic technology in medicine<sup>5</sup>are paradoxical observations inconsistent with both the scientific basis of medicine and the rhetoric of health care planners and administrators. While science and rhetoric provide a picture of the ideal (which admittedly in the "real" world is rarely achieved) and though the number of decision-makers (each with his or her perspective) influencing the diffusion of health care technology is large, the persistence of this paradox should be of concern. Although one assumes that various decision-makers are well intentioned and seek to promote the use of the best possible health care technology, it must be remembered that behavior rather than intention is of critical importance: "The
Low-tryptophan diet in treatment of psoriasis
Authors: J. W. Petrozzi
Journal: JAMA (1968)

Of all the dietary regimens proposed for the treatment of psoriasis, none has excited more public interest than the turkey diet low in tryptophan recently reported by Spiera and Lefkovits.<sup>1</sup>The authors recorded dramatic clearing in four patients with long-standing psoriasis within two weeks after instituting treatment with the "tryptophan deficient" diet. The following case reports show failure of response in three hospitalized patients with psoriasis who were given a diet believed to be low in tryptophan. Analysis of the dietary constituents revealed that turkey, the main protein component of the diet, actually contained significant amounts of tryptophan. <h3>Report of Cases.—Case 1.—</h3> A 16-year-old white boy had disabling pustular psoriasis for the past two years. The disease was first observed during infancy and then subsided without recurrence until the age of 13. During the past two years he had required hospitalization several times because of generalized pustular
Keyword Index ? Volumes 63+64
Journal: Cardiovascular Research (2004)

Keyword Index -Volumes 63 + 64 Acidosis (63) 700 Actin-binding protein (64) 315 Acute hemorrhagic shock (63) 357 Adenosine (63) 313, (63) 739 Adenoviral expression (64) 132 Adenylyl cyclase (63) 709 Adrenergic (63) 561 Adrenergic agonists (64) 125 Adrenergic antagonists (63) 662, (64) 32 Adrenergic receptors (63) 391 h-Adrenoceptors (63) 423 h-Adrenergic receptors (63) 414 Adrenocorticotropin (63) 357 Advanced glycation end products (63) 582 Ageing (64) 544 Alpha receptor (63) 443 Alpha (63) 561 Amphetamine (63) 98 Angiogenesis (63) 226, (64) 603, (64) 115, (64) 356, (64) 421 Angioplasty (63) 22, (64) 165 Angiotensin (63) 236, (63) 423 Angiotensin II (63) 433, (63) 553 Angiotensin-II (63) 176 Anoxia/reoxygenation (63) 323 ANP (63) 443 Aorta (63) 709, (63) 719 Apocynin (63) 323 Apoptosis (63) 208, (63) 487, (63) 682, (64) 144, (64) 365, (64) 496 Arachidonic acid (64) 234 2-Arachidonoyl glycerol (63) 155 Arrhythmia (63) 653 Arrhythmia (mechanism) (64) 52 Arrhythmia (mechanisms) (63) 520, (64) 467 Arrhythmia therapy (64) 12 Arrhythmias (63) 236, (64) 260, (64) 488 Arterial hypertension (63) 176 Arterial injury (63) 603 Aspirin (64) 243 Atherosclerosis (63) 139, (63) 149, (63) 176, (63) 347, (63) 582, (63) 593, (64) 144, (64) 208, (64) 544 Atrial ectopy (64) 250 Atrial fibrillation (63) 236, (64) 387 Atrial fibrosis (64) 387 Atrial myocytes (64) 84 Atrial natriuretic peptide (63) 528 Atrial remodeling (64) 387 Atrioventricular block (64) 268 Autonomic nervous system (64) 72, (64) 125, Beta-receptor (63) 443 Blood flow (63) 331, (64) 356 Ca 2+ /calmodulin-dependent protein kinase II (63) 476 Ca 2+ channel (64) 52 Ca 2+ (64) 227 Ca-channel (64) 536 Calcineurin (63) 467 Calcium (63) 283, (63) 537, (63) 561 Calcium (cellular) (63) 245, (63) 450, (63) 545, (63) 662, (64) 52 Calpain (64) 105 Calsequestrin (63) 264, (64) 227 Capillary permeability (63) 149, (64) 337 Capillary (63) 731 Cardiac contractility (63) 414 Cardiac hypertrophy (63) 196, (63) 391, (63) 423, (63) 458, (63) 467, (63) 476, (63) 537 Cardiac myocytes (63) 98 Cardiac preconditioning (63) 414 Cardiomyocyte (63) 51 Cardiomyocytes (64) 496, (64) 516 Cardiomyopathy (63) 293, (63) 689 Cardiovascular diseases (64) 179 Catheters (64) 208 Caveolin proteins (63) 747 Caveolin (64) 234 CDK (63) 11 Cell culture/isolation (64) 94 Cell culture (63) 98 Cell cycle (63) 617, (64) 132, (64) 395 Cell differentiation (64) 94 Chemokine (63) 51 Cholesterol (64) 144, (64) 346 CK2 (63) 264 Collateral circulation (64) 356 Computer modeling (64) 250 Conduction (block) (64) 40 Conduction system (63) 77 Conformation (64) 227 Congenital defects (64) 40, (64) 365 Congenital long QT syndrome (64) 268 Connexin 43 (63) 98 Connexin43 (63) 109 Connexins (63) 77 Contractile activity (63) 537 Contractile function (63) 245, (63) 283, (63) 673 Contraction band necrosis (63) 109 Coronary circulation (63) 338 Coronary disease (64) 172 Coronary intervention (64) 165 Cross-talk (63) 305, (63) 423, (63) 443 CUG-FGF-2 (63) 458 Cx40 (64) 402 Cyclic strain-mediated regulation (63)
REVELATIONS
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The effect of posture on central blood volume in patients with preascitic cirrhosis on a sodium-restricted diet
Authors: F Wong, P Liu, Y Allidina, L Blendis
Journal: Hepatology (1996)

The status of the central blood volume in cirrhosis is controversial. A combination of sodium restriction and upright posture, which redistributes intravascular volume to dependent parts of the body should further aggravate a contracted central blood volume reduction. The aim of this study was to determine the effect of upright posture and sodium restriction on central blood volume (CBV) in preascitic cirrhotic patients, compared with controls. Eight male, preascitic, alcoholic cirrhotic subjects and eight healthy male controls were studied while on a 20-mmol/d sodium diet. Measurements of CBV by radionuclide angiography, and neurohumoral factors were performed on day 7 in both supine and erect positions and cardiac output and systemic vascular resistance (SVR) was calculated. Sodium restriction resulted in less weight loss in the cirrhotic patients ( P = .03), with significantly lower plasma renin activity ( P = .001). Similar central blood volumes and systemic hemodynamics were observed in both groups in the supine posture. In contrast to the cirrhotic patients, in the control subjects, upright posture resulted in a significant reduction in cardiac output ( P = .002) and increase in SVR ( P = .005), associated with a decrease in all blood volumes which were significantly less than in the cirrhotic patients. Mean arterial pressure was maintained in both groups in both postures. In conclusion, with sodium restriction, preascitic cirrhotic patients have less intravascular volume contraction than control patients. Erect posture results in redistribution of this relatively expanded intravascular volume to the CBV. Therefore, a low-sodium diet can be safely administered in preascitic cirrhotic patients.
Sudden Intimacies
Authors: Michael Radetsky
Journal: JAMA (1985)

For over a year this infant had spent more of his time in the hospital than out. He had a form of histiocytosis X with immunodeficiency, but no one truly knew the prognosis. We had all hoped for the best: that he would slowly outgrow his disease while we treated the interminable complications as they arose. He was a darling boy, with a round face, a willing smile, his father's tendency to crinkle up his nose, and blond hair that stood up vertically on his head. He was readmitted to the hospital because his fever had returned and the eczematous rash had flared up. None of us thought that he would die. But, he developed a right-sided facial palsy, began to choke on his secretions, and had to be intubated. Seizures followed, with coma and eventual brain death due to uncertain causes. One week before his death, the boy's father
Vitamin A physiology
Authors: O. A. Roels
Journal: JAMA (1970)

The earliest knowledge of the nutritional value of vitamin A stemmed from the recognition of the abnormal physiology which resulted from its absence. One of the first symptoms is night blindness. Its nutritional cure has been known for thousands of years. Eber's papyrus, written about 3,500 years ago, prescribed roast ox liver or the liver of black cocks to prevent night blindness. One thousand years later, Hippocrates also recommended the use of ox liver for the cure of night blindness. In 1956, I found that cock's liver was still prescribed by medicine men in Ruanda (central Africa) to treat young boys for night blindness and Bitot's spots. However, it was not until the early part of the 20th century that experimental observations led to the discovery of vitamin A.<sup>1</sup>Osborne and Mendel at Yale University and McCollum and Davis at the University of Wisconsin realized that a fat-soluble factor
The role of crying activity in Apgar scoring. Intercomparisons among the signs of the Apgar scale
Authors: S. Karelitz
Journal: JAMA (1966)

THE APGAR SCORE<sup>1</sup>is designed to determine the physical condition or viability of the newborn 60 seconds after birth, and it has been established that there is a strong association between low scores and neonatal mortality.<sup>1-4</sup>Two of the five segments comprising the score involve crying, and the response sought to one of them (respiratory effort) is a "strong cry" (Table 1). The second sign(reflex irritability) lists "cry" in response to a tangential foot slap. The diagnostic value of the cry alone, reported in previous studies,<sup>5,6M</sup>suggested the potential importance of its role within the Apgar score; thus, it seemed feasible to isolate for study the two segments, respiratory and reflex, in order to determine their relative contribution to the total score. Since Apgar<sup>2</sup>has already mentioned that some of the signs of her test may be more discriminative than others, it was decided to compare each of the signs with the other and with the total score. The cry segments and the total score were also compared with an independent measure of the newborn's crying activity taken from magnetic tape recordings made in the delivery room. In this manner, the "on-the-spot" Apgar evaluation of the cry