tbuckley/cabot-search huggingface dataset:
THE UNION OF MEDICAL SCHOOL AND UNIVERSITY.
Journal: JAMA (1889)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pediatrics, Springfield, Ill.
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dilemmas and solutions
Authors: F. R. Harrison
Journal: JAMA (1974)

RECENTLY, the popular press has carried articles dealing with the biomedical sciences and technology, and human values. It is stated that physicians seem perplexed by some of the complicated moral decisions thrust on them in the practice of their profession. Situations such as the following are said to generate moral dilemmas that cannot be easily, if at all, sequestered in a physician's daily work. An infant is born with a critical physical defect that is not correctable given current medical knowledge and technology. What should the attending physician do? Two persons need a kidney transplant in order to survive, but there is only one kidney available. How can the surgeon determine which candidate will undergo surgery? A person needs an immediate heart transplant, but at the time there are no available hearts. However, a patient has made provisions to donate his heart on death. This patient is,
Recent developments in secondary prevention and cardiac rehabilitation after acute myocardial infarction
Journal: BMJ (2004)

69-81 months, P = 0.05; doctor diagnosed asthma, 91 months, P = 0.005), it should be noted that, because of small numbers in some groups, the confidence intervals were wide and the results did not support the hypothesis.When we adjusted for potential confounding factors we detected no significant associations (P = 0.1-0.8).took part and the midwives for their cooperation and help in recruitment.The whole ALSPAC study team comprises interviewers, computer technicians, laboratory technicians, clerical workers, research scientists, volunteers, and managers who continue to make the study possible.The ALSPAC study is part of the European Longitudinal Study of Parents and Children initiated by the World Health Organization.Contributors:
Chicago.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Problem of Multiple Inference in Identifying Point-Source Environmental Hazards
Authors: Duncan C. Thomas
Journal: Environmental Health Perspectives (1985)

Point-source environmental hazards are often identified by examination of unusual clusters of disease cases. The very large number of potential clusters give rise to the statistical problem of "multiple inference," i.e., the more clusters examined, the greater the risk of "false-positive" associations emerging by chance alone. This paper first distinguishes the situation of clusters identified by anecdotal observation from those that emerge from systematic searches. The latter may or may not include a systematic enumeration of potential causal factors associated with each potential disease cluster. If exposure information is not systematically available, empirical Bayes procedures are suggested as a basis for ranking the observed clusters in order of priority for further investigation. If exposure information is systematically available, empirical Bayes procedures can be used to select associations to report or to rank them in order of priority for confirmation. In addition, procedures are described for testing the global null hypothesis of no exposure-disease associations and for estimating the number of true-positive associations. These approaches are advocated in preference to classical frequentist approaches of multiplying p values by the number of tests performed.
Error in Affiliations
Authors: Michael Yokell, Scb Delgado, Nickolas Zaller, N Wang, Samuel Mcgowan, Traci Craig Green
Journal: JAMA Internal Medicine (2014)

The economic and health care utilization burden that overdose exacts on US EDs and the health care system in general was substantial in our national sample.These findings suggest that the costs associated with opioid overdose are significant and that strategies to reduce morbidity and mortality resulting from overdose are urgently needed, including enhanced access to substance abuse treatment.This study found 135 971 visits to US EDs for opioid overdose in 2010 alone.This number represents only a portion of all opioid overdoses because many individuals never present to an ED or die without activation of the emergency medical services system.
Editorial: Sexual development in mentally handicapped children.
Journal: BMJ (1976)

Regarding the issue of sterilization of the mentally handicapped, there has recently been a televised debate sponsored by the Royal Institution on this topic which has served the purpose of revealing the confused thinking that has characterized this subject. Sterilization of children has been confused with the issue of sterilization of adolescents, and, additionally, no clear distinction has been made betwe en the problems of the more severely and the mildly retarded individuals. The concern about reproduction by the mentally handicapped generally is based on the questions of whether the child will be retarded and whether the mentally handicapped parent can be a good parent. In regard to the 1st question, most of the children of the mentally handicapped have intelligence within a normal range. In the cases of the severe mentally handicapped, pregnancy is usually unlikely, the etiology is unknown, and the genetic risk is low. Regarding whether the mother will be capable of caring for the child, recent surveys have reflected a wide range of circumstances and social conditions that may be found, but there is, in fact, no good reason for the prophylacit sterilization of the mentally handicapped child. For mildly retarded children, sterilization is contraindicated for different reasons. Most of these children need to be a part of the community and be gainfully employed. A few of this group may wish to marry and have children. This group has the same need for sexual education as intelligent children, and they may request or be advised on contraception. If pregnancy occurs under the age of 16, abortion may be considered, but any relatively irreversible procedure such as sterilization should be performed only after serious consideration by both the individual and her advisors.
THE JOURNAL.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nurses and Nursing.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dr Mom
Authors: Margaret Levy
Journal: JAMA (1987)

I am not a liberated woman. I am incarcerated in a world and life-style far more complex and complicated than my great-grandmother (raising her 11 children in an apartment in the Bronx) could have imagined. I don't care whether I am addressed as Miss, Mrs, Ms, doctor, nurse, chairman, chairperson, sir, ma'am, or hey-there. I used to become very angry when patients would call out to me, "Hey, nurse, I need a bedpan." It's far easier just to give them a bedpan. When I was a medical student, I was naive enough to believe that I could do everything I wanted to do. I had no role model. Yes, I knew women who were physicians, even a couple of whom were surgeons. But these people were aberrations to me—unhappy, unbalanced, androgynous, and often downright hostile. Now that a decade has passed since I was graduated from medical school, I realize
Update: HIV Counseling and Testing Using Rapid Tests—United States, 1995
Journal: JAMA (1998)

Approximately 25 million persons each year in the United States are tested for antibody to human immunodeficiency virus (HIV). Publicly funded counseling and testing (CT) programs conduct approximately 2.5 million of these tests each year. CT can have important prevention benefits; however, in 1995, 25% of persons testing HIV-positive and 33% of persons testing HIV-negative at publicly funded clinics did not return for their test results. Rapid tests to detect HIV antibody can be performed in an average of 10 minutes, enabling health-care providers to supply definitive negative and preliminary positive results to patients at the time of testing, potentially increasing the overall effectiveness of CT. In comparison, results from enzyme immunoassays (EIAs) currently used for HIV screening often are not available for 1-2 weeks. To quantify the potential advantages and disadvantages of using rapid tests for CT, CDC estimated the potential impact on the number of persons who would learn their HIV-test results. This report summarizes the results of the analysis and provides the basis for changing the Public Health Service (PHS) recommendations for providing HIV-test results.
Abstract 23074: The Department of Justice Investigation and ICD Implantations Not Meeting Medicare’s National Coverage Determination
Authors: Nihar R Desai, Craig Parzynski, Ralph Brindis, Erica Spatz, Claire Masters, Karl Minges, Pamela Peterson, Fred Masoudi, William Oetgen, Alfred Buxton, Douglas Zipes, Jeptha Curtis
Journal: Circulation (2017)

Background: In 2010, the Department of Justice (DOJ) announced an investigation into the placement of implantable cardioverter defibrillators (ICDs) outside CMS’ National Coverage Determination (NCD). Recently, more than 500 hospitals reached settlements with the DOJ totaling $250 million. We sought to examine the potential impact of the DOJ investigation on clinical practice. Methods: Within the NCDR ICD registry, we calculated the proportion of initial primary prevention ICDs among Medicare beneficiaries not meeting NCD criteria between January 2007 and December 2015 stratified by whether the implanting hospital eventually paid a settlement to the DOJ. To examine changes in primary and secondary prevention ICD volume, we restricted to facilities implanting at least 10 ICDs in each year of the study. Results: A total of 331,349 ICD procedures from 1820 hospitals were included; 452 of these hospitals settled with the DOJ. Prior to announcement of the DOJ investigation in 2010, hospitals that eventually settled had significantly higher proportions of primary prevention ICDs that did not meet NCD criteria (P&lt; 0.001, Figure left panel). Following the announcement of the DOJ investigation, the proportion of implantations not meeting NCD criteria declined at all hospitals, but the pace of decline accelerated and was significantly larger in hospitals that settled (P int = 0.009). Over the study period, there was a 33% decline in primary prevention ICD volume at hospitals that settled with DOJ as compared with a 17% reduction at hospitals that did not settle. In contrast, the volume of secondary prevention ICDs remained relatively constant over time (Figure, right panel). Conclusion: The proportion of primary prevention ICDs not meeting NCD criteria has declined at all hospitals. Announcement of the DOJ investigation was associated with more rapid and larger reductions at hospitals that settled without evidence of unintended consequences on secondary prevention ICDs.
THE OFFICE PRACTICE OF INTERNISTS
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
OUR NOBEL LAUREATES
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Goulstonian Lectures ON AUTO-INTOXICATION: ITS RELATION TO CERTAIN CARDIO-VASCULAR DISORDERS: Delivered before the Royal College of Physicians of London on March 13th, 15th, and 20th, 1906
Authors: H. B. Shaw
Journal: BMJ (1906)

Jo I of the pyrexia was 4.0 days; 103.6°F.was the highest temperature recorded.In most of the cases the thermometer did not rise above 101°.The pulse was quick, but examination of the heart revealed nothing beyond hurried action, nor was there any other sign or symptom found to suggest a rheumatic origin for the condition of the throat.In a few cases patches of transient non-punctate erythema capriciously distributed over the trunk and limbs were observed.In onie case a tlhick crop of herpes developed on the chin.Though albuminuria might have been present at an earlier stage of the disease it did not recur at this period.The faucial exudation was almost always discrete, disappearing in a few days with or without ;syringing of the throat.In only one case was antitoxin injected, as the patches showed a tendency to coalesce.Three successive negative cultures proved that the angina was not diphtherial.Owing to the aggravated form which serum manifesta- tions assume wlhen antitoxini lhas been administered afresh, after an interval of a few weeks, faucial deposit occurrinig late in convalescence from diphtheria as distinct fromn that designated anigina redux, wliich usually requires no treatment, should be dealt witlh first by local measures.As will be seen from the above figures, the chances in favour of the tonsillitis being non-specific in origin dlecidedly outweigh those of its being due to a fresh attack of diphtheria.
Phase Ib study of drozitumab combined with first-line FOLFOX plus bevacizumab (BV) in patients (pts) with metastatic colorectal cancer (mCRC).
Authors: C. S. Rocha Lima, J. C. Baranda, J. Wallmark, Y. Choi, S. Royer-Joo, C. C. Portera
Journal: Journal of Clinical Oncology (2011)

546 Background: Drozitumab is a monoclonal antibody that triggers tumor cell apoptosis by selective agonistic interaction with the Apo2 ligand/TNF-related apoptosis-inducing ligand death receptor 5. This study assessed the safety of drozitumab combined with FOLFOX+BV as first-line therapy in mCRC pts. Methods: Multicenter, open-label study of 2 sequential dose cohorts. Cohort 1 = 3.5mg/kg after 5 mg/kg loading dose (n=3); Cohort 2 = 7mg/kg after 10mg/kg loading dose (n=6). Pts were treated on 14-day cycles (drozitumab, FOLFOX, and BV 5mg/kg on Day 1 of cycle) until disease progression or toxicity. Dose-limiting toxicity (DLT; primary outcome measure) was assessed through 2 cycles (Days 1-28). Adverse events (AE) were recorded through all cycles. Response was assessed by RECIST. Results: A total of 9 pts received 1-22 cycles (median 11) of drozitumab. No DLTs occurred. Most frequent AEs were neutropenia (89%), diarrhea (78%), nausea (78%), fatigue (67%), and anemia (56%). Most frequent Grade ≥3 AEs were fatigue (33%), anemia (22%), diarrhea (22%), hypokalemia (22%), and neutropenia (22%). One pt was discontinued from study drug due to serious AE of vancomycin-resistant enterococcal sepsis assessed as unrelated to drozitumab. Other reasons for discontinuation included disease progression (4 pts), physician's decision (3 pts) and patient's decision (1 pt). Among the 9 patients, best responses included five Partial Responses (2 confirmed and 3 unconfirmed), three Stable Disease, and one missing. The sponsor stopped the study enrollment early for reasons unrelated to safety or efficacy. Conclusions: Addition of drozitumab to first-line FOLFOX+BV was well tolerated overall in these mCRC pts. AEs were similar to those previously reported for FOLFOX+BV alone. Tumor responses suggest no adverse interactions between drozitumab and the chemotherapy evaluated in this study. [Table: see text]