tbuckley/cabot-search huggingface dataset:
JAMA Internal Medicine
Authors: Phil Fontanarosa, Annette Flanagin, Paula Glitman, Lauren Fischer, John Mcfadden, Donald Smith, Karen Boyd, Rochelle Lodder, Diane Cannon, Connie Manno, Fred Marshall, Laura Copyreaders, Catherine Adamcyzk, Jan Alden, Mary Clavey, Gillian Coerver-Connolly, Laura Dickens, Juliann King, Donna Tarsney, Caroline Thordsen, Wanda Assistant, Larry Bryant, Monica Mungle, Elaine Managers, Staff Gardner- Gullens, Fanny Brown, Paul Frank, Rachell Lozano, Michaela Mark, Kathryn Muskovich, J Neff, Kate Pezalla, Gale Saulsberry, Michael Berkwits, Michelle Kurzynski, Eric Butkus, Christopher Hastings, Craig Mccaffrey, Reuben Rios, Ronna Henry, Staff Bird, Alison Burke, Cassio Lynm, David Song, Deputy Livingston, Thomas Cole, Marla Hall, Deanna Willis, Yolanda Davis, Joseph Thornton, Jann Ingmire, Deanna Bellandi, Jim Periodical, Thomas Staff, Monica Smith, Jeffery Bonistalli Manager, Kathy Staff, Mirna Monal, Patricia Quilty, Thalia Moss, Tem Harrier, Susan Henning, Mark Thornbury, Tricia Castellano, Saskia Bolore, Gretchen Linder, Brian Mccartney, Rebecca Haas, Christine Hearne, Irma Lara, Audra Lawlor, Scott Marketing, Matt Herron, Elizabeth Solaro, Geoffrey Flick, Paul Gee Managers, Rick Bell, Michael Mcgraw, Sara Nagy, Stacy Staff, Millette Jackson-Bates, Karen Adams-Taylor, Karl Elvin, Sue Sherrill, Brian Shields Managers, David Antos, Chris Borden, Debbie Camp, Lydia Cruz, Diane Darnell, Colleen Kelly, Chris Meyer, Jaye Mize, Annemarie Neff, Sean O'donnell, Sean Ohlson, Phil O'leary, Ryan Patella, Susan Price, Denise Steinhauser, Production Services, Kim Boler, Rhonda Brown, Timothy Burke, Daniel Degroot, Jordynn Farrar, Euwanaha Joiner-Smith, Cindy Rendlen, Ellen Yoshihara, Circulation Services, Julie Burton, Dexter Golden, Erin Hinchcliff, Noemi Rivera, Geneine Van, Someren Composition, New Media, Gail Barrett, Regina Brownlee, Brenda Chandler-Grayer, Scott Curl, Amy Evers, Teri Hutchison, Mary Kuranda, Joshua Lampinen, Patricia Panek, La Son, Diggs Sledge, George Thomson Graphics, Joe Amft, Maria Duda, Fred Furtner, Carolyn Hall, Maria Kowalkowski, Proofreading Carol, Joy Farrell, Daniel James, Judith Literskis, Teresa Omiotek, James Madara, Bernard Hengesbaugh, Jeffrey Tabas, San Francisco, Paul Varosy, Gregory Marcus, Nora Goldschlager, California Cme, Rebecca Larson, California Less, Is More, Deborah Grady, Mitchell Katz, Los Angeles, Patrick California, David Glidden, John Neuhaus, Kenneth Covinsky, Joseph Ross, New Haven, Raman Khanna, Kathleen Mckibbin, Katherine Gilhooley, Mary Kohut, Howard Bauchner, Rita Redberg, Rosemary Gibson, Shannon Brownlee, Robert Steinbrook, Judyann Bigby, Ezekiel Emanuel, Mark Feinglos, Chi-Yuan Hsu, Kurt Kroenke, Grace Lin, Mary Mcdermott, C Noel, Bairey Merz, Samia California, Robert Phillips, Michael Pignone, Chapel Hill, North Carolina, Judith Prochaska, Bruce Psaty, Kathryn Rexrode, Mary Tinetti, Nicolas Rodondi, Iona Heath
Journal: JAMA Internal Medicine (2013)
GI highlights from the literature
Authors: Mairi H McLean
Journal: Gut (2016)

<h3>Background and Aims:</h3> Acute pancreatitis is an inflammatory disease involving acinar cell injury, and the rapid production and release of inflammatory cytokines, which play a dominant role in local pancreatic inflammation and systemic complications. Toll-like receptor 4 (TLR4) initiates a complex signalling pathway when it interacts with lipopolysaccharide (LPS), which ultimately results in a proinflammatory response. We hypothesised that TLR4 is important in the pathophysiology of acute pancreatitis, independently of LPS. Using two different models of acute pancreatitis, we investigated how genetic deletion of TLR4 or its co-receptor CD14 effects its progression and severity. <h3>Methods:</h3> We induced acute pancreatitis by administering either caerulein or l-arginine to wild-type, TLR4<sup>−/−</sup>, and CD14<sup>−/−</sup> mice. Control mice received normal saline injections. The severity of acute pancreatitis was determined by measuring serum amylase activity, quantifying myeloperoxidase (MPO) activity in the pancreatic tissue, and histologically assessing acinar cell injury. <h3>Results:</h3> It was found that administering caerulein and l-arginine to wild-type mice resulted in acute pancreatitis (as assessed by hyperamylasaemia, oedema, increased pancreatic MPO activity, and pancreatic necrosis) and associated lung injury. The same treatment to TLR4<sup>−/−</sup> or CD14<sup>−/−</sup> mice resulted in significantly less severe acute pancreatitis, and reduced lung injury. We found no evidence of either bacteria or LPS in the blood or in pancreatic tissue. <h3>Conclusions:</h3> The severity of acute pancreatitis is ameliorated in mice that lack either TLR4 or CD14 receptors. Furthermore, these results indicate that TLR4 plays a significant pro-inflammatory role independently of LPS in the progression of acute pancreatitis.
'Pre-Olympic' games, now in progress, demand world-class medical teamwork
Authors: V. M. Cowart
Journal: JAMA (1987)

US ATHLETES currently are competing in the Pan-American Games in Indianapolis. Keeping them fit for competition is the main task of the US medical team, a job that the chief physician says often calls for resourcefulness because of the unique demands of sports medicine. For example, "an injury of lesser severity for you or me could be devastating for an elite athlete," says William A. Grana, MD, the chief physician. "These people have to be ready to compete all the time. They can't just take three or four days off." The US medical contingent includes Grana, an Oklahoma City orthopedic surgeon; orthopedic surgeons David Joyner, MD, Camp Hill, Pa, and Melvin Hayashi, MD, Thousand Oaks, Calif; family practitioner Richard Levandowski, MD, Princeton, NJ; Joseph Perlman, MD, a plastic surgeon from Waco, Tex; and about 25 other persons, primarily trainers. They have been in Indianapolis since July 30. Although most athletes
Effects of endothelin-1 on airway and parenchymal mechanics in guinea-pigs
Authors: A Adamicza, F Petak, T Asztalos, Z Hantos
Journal: European Respiratory Journal (1999)

The contributions of the airways and the parenchyma to the overall lung mechanical response to endothelin-1 (ET-1) have not been systematically studied. In this investigation, the ET-1 induced changes on lung mechanics in guinea-pigs were separated into airway and parenchymal components. Pulmonary impedance (ZL) data were collected between 0.5 and 21 Hz in six anaesthetized, paralysed, open-chest animals by introducing small-amplitude pseudorandom oscillations into the trachea through a wave tube. ZL was calculated before and following intravenous boluses of ET-1, with doses doubled from 0.125-2 microg x kg of body weight(-1). A model containing an airway resistance (Raw) and inertance (Iaw) and tissue damping (G) and elastance (H) was fitted to the ZL spectra in each condition. Parenchymal hysteresis (eta) was calculated as G/H. After each dose, ET-1 induced significant increases in Raw (at peak response mean+/-SEM: 424+/-129%), G (400+/-80%), H (95+/-22%) and eta (156+/-33%), whereas Iaw decreased following the two highest doses (-291+/-77%). These data suggest that the parenchymal constriction was accompanied by inhomogeneous constriction of the peripheral airways.
PRAGTIGAL NOTES.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
EXTERMINATION OF MALARIA.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
"GROUP PRACTICE; DIAGNOSTIC AND PAY CLINICS"
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medicine To-day
Authors: G. Birdwood
Journal: BMJ (1965)

U.W.I.) confirmed the predictive value of bacteriuria as an index of subsequent clinical pyelonephritis and showed the higher incidence of pre- maturity and the hypertensive disorders of pregnancy in bacteriurics than in non- bacteriurics.An important study on renal function in infantile malnutrition by Dr. G. A. 0. ALLEYNE (Jamaica) showed that there was a consistent reduction in glomerular filtration rate, an inability to excrete free water, and an impairment in the ability of the kidney to produce a concentrated urine.Improvement in these indicators of kidney function took place during recovery from severe protein-calorie malnutrition.Dr. J. S. GARROW (M.R.C.Tropical Metabolism Research Unit, Jamaica) presented results of measurement of total body potassium in infantile malnutrition by means of a scintilla- tion counter.A reduction of up to 50%. of the normal value of total body potassium was found in the oedematous kwashiorkor infant even if serum potassium levels were normal.Disappearance of clinical oedema was asso- ciated with a rapid increase of total body potassium.Marasmic infants or nonoedematous malnourished infants showed a relatively smaller deficit of total body potassium.Dr. P. CURZEN (U.W.I.) reported results of investigations of enzyme histochemistry on 92 placentae obtained from normal and abnormal pregnancies of different stages of gestation.The author suggested that a high concentration of alkaline phosphatase and glucose-6-phosphatase, together with a low concentration of acid phosphatase, constituted the histochemical indices of placental in- sufficiency.A paper by Dr. J. B. DAVIES of the Sandfly Research Unit, Jamaica, demonstrated that the emergence rates of three species of culicoides were closely related to the tidal amplitude and mean weekly tide levels, thus establishing that control of these insects could be brought about by water management methods.Dr. T. M. W. POON-KING (Trinidad) reported on an epidemic of acute glomerulonephritis which occurred recently in South Trinidad.Two hundred and ninety-seven patients were admitted to hospital, and children between the ages of 3 and 9 years were most frequently affected.
Dermatitis Herpetiformis
Authors: Louis A. Duhring
Journal: JAMA (1983)

Under the name Dermatitis Herpetiformis I propose to place a number of cases of skin disease that I have encountered from time to time. These cases at present are for the most part nameless, having been regarded and diagnosed, either as peculiar manifestations of one or another of the commoner and well-known diseases, as eczema, herpes, or pemphigus, or, in some cases, as undescribed diseases. From these remarks it will be inferred that the disease is rare, and such in a measure is the fact. At the same time I have met with a sufficient number of cases during the last fifteen years, to warrant the view that the disease is worthy of a special description and a name. I first recognized the affection as being peculiar as far back as 1871, but with the few cases observed at that time was at a loss to classify or to treat
Oregon's methods. Did cost-effectiveness analysis fail?
Authors: D. M. Eddy
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Therapy of Ischemic Cerebral Vascular Disease Due to Atherothrombosis
Authors: J. Philip Kistler, Allan H. Ropper, Roberto C. Heros
Journal: New England Journal of Medicine (1984)

MOST ischemic cerebral vascular disease results from arterial narrowing or occlusion. The pathologic process may involve vessels of any size and may be intrinsic to the vessel, as in atherosclerosis, lipohyalinosis, inflammation, or dissection, or it may arise when embolic material from the heart or extracranial circulation lodges in an intracranial vessel. Because the brain cannot repair itself by forming new tissue, therapy in ischemic cerebrovascular disease is primarily preventive, though protecting ischemic brain tissue from the secondary effects of stroke is sometimes successful. The prelude to therapy is a precise diagnosis that includes not only characterization and localization of . . .
Book Review
Authors: R. DOUGLAS COLLINS
Journal: Annals of Internal Medicine (1977)

Comments and Correction1 April 1977Book ReviewR. DOUGLAS COLLINS, M.D., F.A.C.P.R. DOUGLAS COLLINS, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-86-4-511_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I find Stanley Goldfarb's review of my bookIllustrated Manual of Fluid and Electrolyte Disorders(Ann Intern Med85:833-834, 1976) both inaccurate and full of value judgements. For example, he states the book proposes that "pathologic diaphoresis somehow leads to water excess." In fact, nowhere in the illustration on page 94 or in the discussion of pathologic diaphoresis on page 95 is water excess demonstrated or mentioned.His conclusion that the section on differential diagnosis proposes a "concept that the diagnosis of fluid and electrolyte metabolism should be learned by rote" is simply illogical because the text...Reference1. MCCURDY D: Book review—Illustrated Manual of Fluid and Electrolyte Disorders by R. Douglas Collins, in Gastroenterology 72:188-189, 1977 CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Internal Medicine Pensacola Education Program Baptist, Sacred Heart, and University Hospitals 1000 West Moreno Street Pensacola, FL 32501 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1977Volume 86, Issue 4Page: 511-511 ePublished: 12 March 2020 Issue Published: 1 April 1977 PDF downloadLoading ...
Chronic Obstructive Airway Diseases
Authors: John E. Hodgkin
Journal: JAMA (1975)

THE TWO major objectives of a comprehensive respiratory care program are to (1) control and alleviate as much as possible the symptoms of respiratory impairment and (2) teach the patient how to achieve optimal capacity to carry out his activities of daily living. There is evidence<sup>1-9</sup>that patients treated by a systematized care program of a type summarized in this article are likely to remain functional for longer periods of time and become better able to cope with the demands of their daily living. The focus of the state-of-the-art communication (part of a study funded by the National Science Foundation) on the diagnosis and systematized care of patients suffering from emphysema, chronic bronchitis, and asthma is on the individual and his particular situation, not just the manifestations of his disease. It includes concern for his environmental situation and his personality makeup. Thus, systematized care involves rehabilitation medicine, consideration of
Diabetes management in the USA and England: comparative analysis of national surveys
Authors: A. G Mainous
Journal: Journal of the Royal Society of Medicine (2006)

ObjectivesTo compare diabetes management in adults between England and the United States, particularly focusing on the impact of a universal access health insurance system. DesignAnalysis of the nationally-representative surveys Health Survey of England, 2003 (unweighted n=14 057) and the National Health and Nutrition Examination Survey, 2001–2002 (unweighted n=5411). Main Outcome MeasuresGlycaemic, lipid and blood pressure control and medication use among individuals with previously diagnosed diabetes. ResultsAmong those aged 20–64 the prevalence of diagnosed diabetes was lower in England (2.7%) than in the USA (5.0%). The proportion with diabetes receiving treatment was similar for the two countries. However, the mean HbA1c in England was 7.6%: in the USA it was 7.5% for those with insurance and 8.6% for those without insurance. The proportion of individuals on ACE inhibitors in England was 39%: in USA it was 39% for those with insurance, and 14% for those without. ConclusionsIndividuals in a healthcare system providing universal access have better managed diabetes than those in a market based system once one accounts for insurance.
Clinical Expression of Neurotoxic Injury and Diagnostic Use of Electromyography
Authors: Pamela M. Le Quesne
Journal: Environmental Health Perspectives (1978)

The clinical features of neurological damage produced by acrylamide, lead, organophosphates, hexacarbon solvents, and methylmercury are described, and the differences in effects of these compounds are stressed.The characteristic pattern of electrophysiological changes for each group of substances are described and correlated with pathological rmdings.
Oral Surg, Oral Med and Oral Path, St. Louis
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Questions and Answers
Authors: Walter W. Bond
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal