tbuckley/cabot-search huggingface dataset:
Stem Cell Assays in the Evaluation of Myelotoxicity
Authors: Aroop Mangalik, William A. Robinson
Journal: Environmental Health Perspectives (1981)

The concept and characteristics of different types of hematopoietic cells have been described. Hematopoietic stem cells are currently considered to exist in a variety of populations with different degrees of commitment towards a particular cell line. By a combination of animal studies and studies with hematopoietic disorders, the concept of dividing hematopoietic stem cells into uncommitted and committed types has emerged in the past several years. Uncommitted stem cells are capable of differentiation, under the proper stimulus, into either of the cell lines of the hematopoietic system. These cells form a resting population of cells with a low mitoitic rate and a long resting (G0) phase. The committed stem cells are partially differentiated and mature only into one type of cell. The committed stem cell population is relatively more active than the population of uncommitted stem cells. A variety of assays both in vivo and in vitro are currently available for the study of different hematopoietic stem cells. These assays are semiquantitative. The number of colonies of mature cells which develop after the infusion or plating of a population of cells containing the stem cells is proportional to the total number of cells infused. A variety of toxic as well as biological substances have been assayed in these systems and a quantitative depression of the number of colonies produced has been noted by a variety of workers. The degree of depression in the number of colonies varies with the agent in use and the type of assay employed. These studies have demonstrated that toxicity of chemicals on the hematopoietic stem cells can be studied with these in vitro and animal studies to give an assessment of their potential toxicity in the intact organism. The recent development of the Dexter two-layer liquid culture system has provided a new impetus to the research on the uncommitted stem cell in a variety of organisms.
ABSTRACTS
Journal: Journal of Clinical Investigation (1967)

The correlation between arterial blood pressure and plasma renin has not been consistent.In the present ex- periments the possibility that changes in renal small artery pressure occur without similar changes in systemic arterial pressure was tested in 19 anesthetized dogs.¶f Stimulation of renal nerves at 3, 6, and 12 cycles per second for 20 seconds caused reductions in renal blood flow averaging 71, 83, and 120 ml per minute and increases in small artery pressure averaging 7, 17, and 22 mm Hg, respec- tively.Aortic pressure at the level of the renal arteries did not change significantly and small vein pressure decreased.Inj ections of norepinephrine (2, 4, and 8 ltg) into the aorta caused reductions in renal flow averag- ing 31, 56, and 76 ml per minute, respectively; there was a transient rise followed by a more sustained decrease in small artery pressure; aortic pressure increased slightly and small vein pressure decreased.Bilateral carotid occlusion did not change renal flow or small vein pres- sure; both aortic and small artery pressures increased by averages of 47 and 44 mm Hg, respectively.¶f Acute reductions in renal blood flow by compression of the renal artery caused significant reductions in both small artery and small vein pressures.When the kidney was perfused at constant flow, the increases in perfusion pres- sure and small artery pressure were similar during the interventions.ff Perfusion of a portion of the venous return from the kidney into the hind paw indicated that a vasodilator substance is released from the kidney during the ischemia associated with nerve stimulation.A vaso- constrictor substance was released during nerve stimula- tion at constant renal flow.¶ The results indicate that changes in systemic arterial pressure do not always reflect the magnitude or direction of changes in small renal artery pressure.
Coronary reactivity to acetylcholine varies with a polymorphism in the angiotensin II type 1 receptor gene in women: Data from the NHLBI-sponsored women's ischemia syndrome evaluation (WISE) study Greg O. von Mering, Carl J. Pepine, Susan P. McGorray, Richard A. Kerensky, Paul K. Humphlett, Sheryl F. Kelsey, Dennis M. McNamara, Steven E. Reis, Barry L. Sharaf, George Sopko, Daniel F. Pauly. University of Florida, Gainesville, FL
Journal: Journal of the American College of Cardiology (2001)
Sensitivity Training
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Renal failure and tubular dysfunction due to zomepirac therapy
Authors: S. E. Warren
Journal: JAMA (1983)

RENAL failure has been described due to the use of several nonsteroidal anti-inflammatory drugs that are also inhibitors of prostaglandin synthesis—phenylbutazone,<sup>1</sup>indomethacin,<sup>2</sup>aspirin,<sup>3</sup>fenoprofen,<sup>4</sup>tolmetin,<sup>5</sup>naproxen,<sup>6</sup>and ibuprofen.<sup>6</sup>This report describes acute reversible decline in glomerular filtration rate (GFR) associated with use of zomepirac sodium (Zomax), a new nonnarcotic analgesic that is also an in vitro inhibitor of prostaglandin synthesis. <h3>Report of Cases</h3><h3>Case 1.—</h3> A 65-year-old woman was undergoing treatment for multiple medical problems, including late-onset multiple sclerosis, hypertension, hypothyroidism, and a mixed connective-tissue disease syndrome of nondeforming arthritis, esophageal dysfunction, intermittently present speckled antinuclear antibodies, and increased ESR. She had, in addition, undergone mastectomies in 1949 and 1962 for breast carcinoma, without subsequent recurrence. She came to the nephrology service in 1979 with subnephrotic-range proteinuria and a creatinine clearance of 65 mL/min. Renal biopsy was deferred because of her fragile medical
Tables and Notes on Human Osteology for the Use of Students of Medicine.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Index to Volume XXV, 1966
Journal: Annals of the Rheumatic Diseases (1966)

contribution to a discussion Acid, anthranilic, excretion of, 556 ,-aminocaproic, in scleroderma, failure of, 175 flufenamic, in rheumatoid arthritis, *574 hyaluronic, in Heberden's nodes, 145 kynurenic, excretion of, 556 nicotinic, test of endogenous iron, 547 phosphastase in joint fluid, 137 uric, and public health, *478 reduction of production of, in treatment of gout, 353 in serum, body weight and, 456 estimation of, 184 xanthenuric, excretion of, 556
Acute respiratory distress syndrome
Authors: P V Dicpinigaitis
Journal: BMJ (1994)

length of stay was 30 (30 5) days after entry to the study, and 2367 bed days (8% of the beds in the medical directorate) were used.For those treated, the mean input per patient per weekday spent in hospital was 19-1 (9 9) minutes from physio- therapy, 15-3 (12-2) minutes from occupational therapy, 13 2 (7 9) minutes from speech therapy, and 4-7 (6) minutes from a dietitian.We estimated that 10-12 beds were required for stroke care in our 500 bed district general hospital, which serves a population of 138 000.Previous research suggests that stroke rehabilitation is most effectively provided by flexible use of beds in a rehabilitation ward rather than a demarcated unit.2As a result of our study we have set up a stroke rehabilitation service, for patients of all ages, in an existing rehabilitation ward of a geriatric unit, and physiotherapy for patients with stroke has been increased.This has been achieved by reorganisation with no specific cost implications.We expect this reorganisation to improve medical management.In addition, we hope to improve outcome, as Kalra et al recently showed that a given amount of paramedical treatment is more effective in a stroke unit than a general medical ward'-perhaps because of the contribution made by fimctionally oriented nursing care.4This kind of reorganisation, with no or minimal cost, to provide a stroke service might also be possible for other hospitals.
Mycoplasma pneumoniae infection with arthritis and a varicella-like eruption
Authors: W. Sequeira
Journal: JAMA (1981)

<i>MYCOPLASMA pneumoniae</i>has been recognized as a cause of respiratory tract infections in adults and children for the past 20 years.<sup>1</sup>Since that time, sporadic reports of involvement of other organ systems have appeared in the literature. In 1975 Murray et al<sup>2</sup>reviewed the protean manifestations of this infection. A variety of skin and mucous membrane lesions, while often not of major clinical importance, may occur.<sup>3</sup>Arthritis associated with<i>M pneumoniae</i>infection, though rare, is also well documented.<sup>4-6</sup>Both monoarticular and polyarticular arthritis have been reported, and the duration has varied from a transient episode in the course of a febrile illness to a more chronic disease lasting up to 18 months.<sup>5</sup> This report describes a patient with an acute febrile disorder characterized by a varicella-like eruption, polyarthritis, and a fourfold increase in antibodies to<i>M pneumoniae</i>. There was no evidence of lower respiratory tract
Abstracts of the Annual Meeting of The Endocrine Society
Journal: Endocrine Reviews (1982)

Journal Article Abstracts of the Annual Meeting of The Endocrine Society Get access Endocrine Reviews, Volume 3, Issue 4, 1 October 1982, Pages 417–418, https://doi.org/10.1210/edrv-3-4-417 Published: 01 October 1982
Ruth
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Nasogastric Tube and Pulmonary Ventilation
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cesarean delivery for women presenting with genital herpes lesions. Efficacy, risks, and costs
Authors: A. G. Randolph
Journal: JAMA (1993)

<h3>Objective.</h3> —To assess the effect of cesarean delivery on neonatal and maternal morbidity and mortality and their associated costs for two populations of women presenting with genital herpes lesions at delivery: those with and those without a history of genital herpes. <h3>Data Sources.</h3> —MEDLINE (search for herpes simplex virus and neonatal, cesarean, and mortality) and recognized experts. <h3>Data Extraction.</h3> —The quality of the overall data used for baseline values was graded using a predetermined scale. <h3>Results.</h3> —The practice of cesarean delivery for women with a history of genital herpes lesions that recur at delivery results in more than 1580 excess cesarean deliveries performed for every poor neonatal outcome prevented, a cost per neonatal herpes case averted of $2.5 million and a cost per quality-adjusted life-year gained of $203 000. For these women, lowering the efficacy of cesarean delivery or the herpes simplex virus vertical transmission rate could result in maternal deaths outnumbering neonatal deaths prevented. In contrast, cesarean delivery for women with no history of genital herpes simplex virus who have lesions at delivery has low maternal costs per neonatal benefit and saves money. <h3>Conclusions.</h3> —Women who present with their first clinical episode of genital herpes at delivery should have a cesarean section performed. However, the current practice of cesarean delivery for women with a history of genital herpes lesions that recur at delivery results in high maternal morbidity and mortality at substantial financial expense, underscoring the urgency of examining alternative management strategies. (<i>JAMA</i>. 1993;270:77-82)
Commentaire du travail de Schmidt A et al., pp. 430
Journal: Endoscopy (2015)

See also: Wing-shaped plastic stents vs. self-expandable metal stents for palliative drainage of malignant distal biliary obstruction: a randomized multicenter studyEndoscopy 2015; 47(05): 430-436DOI: 10.1055/s-0034-1391232
Glucose-Dependent Changes in Aortic Wall Metabolism
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Active and Passive Smoking and Pathological Indicators of Lung Cancer—A Report of Limited Value?
Authors: Peter Lee
Journal: JAMA (1993)

<h3>To the Editor.</h3> —Trichopoulos et al,<sup>1</sup>in their autopsy study, report a statistically significant increase in prevalence of EPPL in nonsmokers in relationship to marriage to a smoker. Their argument that this supports "the body of evidence linking passive smoking to lung cancer" is questionable. Use of EPPL is problematic. It is surprising that values of this supposed index of lung cancer risk were somewhat higher in the young than the old, in women than men, and in rural than urban dwellers. Nor was EPPL clearly related to occupation or elevated in ex-smokers. Though it reportedly was raised significantly in current smokers, there was no dose-response, with heavy smokers having virtually identical values to nonsmokers. Although the authors claim their "inspiration and methodologic approach... drew heavily from the studies of Auerbach," Auerbach's results differed greatly. Notably, Auerbach reported a massive difference between smokers and nonsmokers, with nonsmokers showing virtually
Advanced Planning Can Help Prevent Heat-Related Deaths
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SPONTANEOUS GANGRENE.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bendectin—Birth Defects Controversy
Authors: Stuart A. Newman
Journal: JAMA (1990)

<h3>To the Editor.—</h3> The recent Medical News article by Skolnick<sup>1</sup>on issues concerning the morning sickness drug Bendectin, which has been claimed to cause limb reduction and other birth defects, states that "nearly every study provided reassuring evidence that Bendectin was safe." Perhaps he was alluding to epidemiologic studies, which have proved inconclusive. He certainly could not have been referring to the published experimental literature on the direct effects of Bendectin and its antihistamine component doxylamine on isolated limbforming tissues. All of these studies,<sup>2-4</sup>which were performed in one avian and two mammalian species, confirm that Bendectin, at a concentration of approximately 10 mg/L, drastically curtails the formation of embryonic cartilage, the tissue that forms the primordia of the developing skeleton.<sup>5</sup>This is the same concentration range in which diphenylhydantoin, a known teratogen, impairs development of these cells.<sup>2</sup> One recent study<sup>4</sup>has shown that in
ALCOHOLIC NEURITIS.
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal