tbuckley/cabot-search huggingface dataset:
Reply
Authors: Kshaunish Das, Abhijit Chowdhury
Journal: Hepatology (2010)

We read with great interest the comments by Dr. Maitra regarding our article1 published in HEPATOLOGY. We thank the author for his kind interest in our work and welcome the opportunity to clarify the points raised by him. First, there is a difference between a field study and a clinic-based study. Despite its fallacies, the measurement of alanine aminotransferase remains the most cost-effective screening tool for significant underlying liver disease, even nonalcoholic fatty liver (NAFL) disease.2 Moreover, an elevated alanine aminotransferase level is one of the components of the various noninvasive scoring systems used for identifying NAFL subjects with advanced liver disease.3 Unfortunately, despite attempts to develop multiple noninvasive (but not necessarily cheap) scoring systems or tests for identifying subjects with nonalcoholic steatohepatitis, liver biopsy remains the ultimate gold standard for diagnosing nonalcoholic steatohepatitis.3 Second, despite the concerns regarding the unconventional forms of ethanol consumption by tribals in India, there were only 35 tribals (1.8%) among the 1911 subjects, and we rigorously excluded alcohol consumption in our study population (see the supporting information for our article1). Finally, we also speculated about the role of malnutrition in the genesis of NAFL in our population.1 However, in a case-control substudy of subsets of subjects with a body mass index < 18.5 kg/m2, we found that those with NAFL had higher indices of adiposity and a higher prevalence of markers of metabolic syndrome versus those without NAFL (see the supporting tables for our article1). We agree with Maitra that the thrifty phenotype hypothesis,4 introduced approximately 20 years ago to explain the associations between poor fetal and infant growth and the increased risk of developing impaired glucose tolerance and metabolic syndrome in adult life, can play a pathophysiological role in the development of the third-world NAFL phenotype, as highlighted by us.1 Kshaunish Das*, Abhijit Chowdhury , * Divisions of Gastroenterology, Institute of Postgraduate Medical Education and Research, Kolkata, India, Hepatology, School of Digestive and Liver Diseases, Institute of Postgraduate Medical Education and Research, Kolkata, India.
The Impact of Prior Malignancies on Second Malignancies and Survival in MM Patients: A Population-Based Study
Authors: Gudbjorg Jonsdottir, Sigrún H. Lund, Magnus Björkholm, Ingemar Turesson, Anders Wahlin, Malin Hultcrantz, Anna Porwit, Ola Landgren, Sigurdur Y Kristinsson
Journal: Blood (2016)
Spectrochemical Abstracts. Vol. 11: 1938-1939
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
GMC's Professional Conduct Committee
Journal: BMJ (1982)

committees about the dispersal of vacant medical practices, the GMSC should look at the effect of delays in decisions being reached on such issues, and seek guidance from the DHSS on what is 'sufficient time' for consultation and how long an appeal by a community health council to the Secretary of State might take."The committee decided, as a matter of urgency, to look at the whole question of family practitioner commlittee consultation with community health councils.
Kidney Transplantation
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Radiation and Mortality of Workers at Oak Ridge National Laboratory: Positive Associations for Doses Received at Older Ages
Authors: David B. Richardson, Steve Wing
Journal: Environmental Health Perspectives (1999)

We examined associations between low-level exposure to ionizing radiation and mortality among 14,095 workers hired at the Oak Ridge National Laboratory between 1943 and 1972. Workers at the facility were individually monitored for external exposure to ionizing radiation and have been followed through 1990 to ascertain cause of death information. Positive associations were observed between low-level exposure to external ionizing radiation and mortality. These associations were larger for doses received after 45 years of age, larger under longer lag assumptions, and primarily due to cancer causes of death. All cancer mortality was estimated to increase 4.98% [standard error (SE) = 1.5] per 10-mSv cumulative dose received after age 45 under a 10-year lag, and 7.31% (SE = 2.2) per 10-mSv cumulative dose received after age 45 under a 20-year lag. Associations between radiation dose and lung cancer were of similar magnitude to associations between radiation dose and all cancers except lung cancer. Nonmalignant respiratory disease exhibited a positive association with cumulative radiation dose received after age 45, whereas ischemic heart disease exhibited no association with radiation dose. These findings suggest increases in cancer mortality associated with low-level external exposure to ionizing radiation and potentially greater sensitivity to the carcinogenic effects of ionizing radiation with older ages at exposure.
Abstract 1112: Re-isolation and Functional Characterization of Cardiomyocytes after Implantation of Bone Marrow Stromal Cells or Neonatal Cardiomyocytes in Rat Heart
Authors: Motoki Sato, Carolyn A Carr, Daniel J Stuckey, Suzanne M Watt, Kiernan Clarke, Sian E Harding
Journal: Circulation (2007)

Background: Replacement of cardiac muscle is a key goal of cell therapy, but uncertainty exists about whether cell implantation strategies actually generate true functioning cardiomyocytes. We therefore aimed to re-isolate implanted bone marrow stromal cells (BMSCs) to determine their functional characteristics ex vivo . Neonatal cardiomyocytes (NCMs), in which the myocyte phenotype was established before implantation, were used as a gold standard. Methods: NCMs from GFP-transgenic rats were injected into the hearts of nude rats (n=4), and re-isolated after 1, 2 or 4 weeks. These were compared with adult myocytes, and with myocytes from 2 and 4 week-old (2W-O and 4W-O) rats. labelled myocytes detected 2 weeks after implantation of DiI and iron-labelled BMSCs (2W-BI) into infarcted rat hearts (n=4) were studied. Results: GFP-labelled myocytes approaching the adult morphology (rod-shaped, with defined sarcomeres) were not detected until 2 weeks after implantation of NCMs (2W-I), and were significantly shorter than adult myocytes in cell length (52 ± 5μm, n=10 vs. 99 ± 9μm, n=9, p&lt;0.001), but the similar length to those from 2W-O (56 ± 3μm, n=15). Contraction amplitude (% shortening) was significantly lower and time to 50 % relaxation (R50) longer for the re-isolated cells compared with adult. By 4 weeks after implantation (4W-I), re-isolated myocytes were close to the adult phenotype, although cell length (64 ± 5μm, n=20, p&lt;0.01) showed immature characteristics. After implantation of BMSCs, DiI-labelled myocytes were detected in only 4/10 rats and then at low levels (0.4–21 per 10,000). Labelled myocytes, isolated 2 weeks after implantation of BMSCs, had similar length (101 ± 20, n=21), contraction amplitude and beat duration to adult myocytes. Conclusions: Implanted NCMs mature within the heart over a period of at least 4 weeks. The adult phenotype of labelled myocytes after BMSC implantation is inconsistent with a process of transdifferentiation and maturation.
Increased Effort Needed to Prevent Falls as the US Population Ages
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Befriending illness
Authors: Geoffrey Marsh
Journal: BMJ (2006)

positive predictive values might be slightly overestimated.The observed total number of cancers in the practice was similar to the predicted number calculated from national incidence figures, apart from in the oldest age group, where fewer cancers occurred than were expected.When positive predictive values from the three retrospective studies are recalculated for patients aged 50 or more, they are 11% (6.9% to 16.0%), 11% (5.1% to 21.0%), and 2.6% (2.2% to 3.0%). 2-4In the fourth study, 5.2% was quoted for patients aged 60 years or more. 5The lowest of these sets of values comes from a study that examined all rectal bleeding, whereas in the other three studies rectal bleeding was the main reason for consultation.The annual rate of new rectal bleeding in our population was 8.9/1000, compared with 7-21/1000 in the Belgian and UK studies. 3-5The proportion of patients with colorectal cancer in our practice who presented with rectal bleeding was 39%, which is similar to the proportion reported by the largest of the retrospective studies. 4These comparisons suggest that our figures are representative.Only two of our patients with new rectal bleeding and cancer had accompanying diarrhoea.This contrasts with the findings of other studies, and it is important because rectal bleeding without diarrhoea does not qualify for an urgent referral under the current guidance, unless the patient is aged 60 or more, the bleeding persists for six weeks, and no anal symptoms exist.The risk of 5.7% for rectal bleeding on its own for colorectal cancer and 10.6% for all neoplasia suggests that new rectal bleeding in patients aged 45 or over should qualify for urgent referral, whether or not they have other symptoms.The Department of Health's Referral Guidelines for Suspected Cancer published in July 2000 estimated the resources that would be needed to ensure that all patients with suspected cancer would be seen by a specialist within two weeks. 7This estimate was based on a population in which, for every case of colorectal cancer that was diagnosed, 15 other patients would be found to have benign disease.Thus, the population with suspected colorectal cancer referred using this guidance should have about a 7% (1 in 16) absolute risk of having the condition.This implies that a symptom (or pattern of symptoms) with such a level of absolute risk warrants urgent referral.We believe that most patients would accept that the level of risk we found-even at our lower confidence interval of 3.2%-is an adequate reason for investigation, and that current guidelines should be changed.Thanks to the Bristol Bath Gloucestershire Primary Care Network.
Presidential candidate disability
Authors: R. Scalettar
Journal: JAMA (1984)

AS A NEW presidential campaign is about to begin, the health of the presidential candidates should not be ignored. The presence of an ongoing medical problem, intemperate habits such as abuse of alcohol or other drugs, or the development of an acute medical illness during the campaign could easily result in the victory of a candidate elected not necessarily by the will of the people but by default because of an opponent's medical illness. It has now been more than 20 years since the historic presidential campaign of 1960, which resulted in the election of John F. Kennedy. His opponent, the vicepresident of the United States in 1960, Richard M. Nixon, was defeated in an extremely close election. Although the vice-president's political fortune was to decline immediately after this defeat, his presidential victory in 1968 crowned a remarkable political comeback to be followed by his resignation in 1973. The purpose
Functional Diseases of the Intestines
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Small intestinal complications of diverticulitis of the sigmoid colon
Authors: D. Frager
Journal: JAMA (1986)

THE CLINICAL and radiological manifestations of diverticulitis of the sigmoid colon are well recognized. Mild cases respond to medical therapy, while more severe and complicated cases require surgical intervention in approximately 25% to 33% of instances.<sup>1,2</sup>The barium enema examination usually demonstrates the following: (1) paracolic abscess or fistula, (2) spasm of the sigmoid colon, (3) stricturing of the sigmoid, often with complete obstruction, and (4) fistulas to other viscera, particularly the urinary bladder.<sup>3</sup>This study describes the less recognized clinical and radiological findings of small intestinal involvement as a complication of diverticulitis of the sigmoid colon. <h3>Materials and Methods</h3> One hundred forty cases of<i>pathologically documented</i>diverticulitis of the sigmoid, identified at Montefiore Medical Center between January 1980 and December 1985, were reviewed retrospectively. Ten (7.1%) of the patients had evidence of small intestinal involvement at surgery. Nine of these ten patients had a contrast enema examination,
Sussex University
Authors: Paolo Pinelli, D Aitken, I Alloub, K Amatayakul, H Amini, R Barnes, R Brennan, T Busuttil, S Campbell, Ashurst Coles, Lorna Dow, J Ellis, El-S El-Minabbawy, J Felton, Frances Fountain, Mack Hart, H Hart, J Hill, Mary Hutcheon, T Macdonald, Helen Mcewan, R Malone, K Mathie, Krishna Mitra, J Nel, I Orr, E Parry, Mary Paterson, R Pool, Christine Puxon, Saroja Ramaswamy, J Rees, Rita Shannon, Anmola Sinha, Christine Snodgrass, R Stearn, W Sutherland, G Swapp, Brenda Taylor, P Thew, A Thursz, F Walker, A White, G Williams, D Aickin, P Amara- Singhe, R Ansari, Susanta Basu, F Betheras, G Bird, Rohini Borkotoky, C Chapman, Purnima Chatterjee, L Collins, Mck Coltman, J Crow- Ley, Jaon Curtis, Deba Das, Dilip Das, Rajani Das, M L D N K P, De Silva, Sinniah Dharmalingam, J Dommisse, G Duncan, A Dutton, H Edelstein, S Fernando, S George, Meenakshi Ghos, P Glenning, I Goldman, Kshitindra Gun, Dnys Heginbotham, Hilary Jolly, W Jones, J Karunaratne, Anwara Khatun, Ethel Lewin, A De, B Lopes, Therese Lu, F Macdonald, Bimla Mehra, Malika Mehra, A Miller, Zakia Minhas, Charu Mitra, Suryamoni Mitra, Subimal Mukerjee, Nanda Mukherjee, Barun Mukherji, Hasmukh Patel, S Perera, Eva Popper, C Primmer, H Radden, T Ramarao, D Sen, Sen Gupta, R Sivasamboo, Mck Smith, E Still, T Van Helsdingen, D Waghmarae, E Welch, L Wright, C Yu, A Ghosh
Journal: BMJ (1976)

6 Penywern Road, Earls Court, London SW5 9ST.The Organisation of the Inpatient's Day Recommendations from nurses' training requirements to the treatment of children in hospital, the choice of meals, and visiting arrangements are made in a report, The Organisation of the Inpatient's Day, produced by a committee of the Central Health Services Council (HMSO, £135).There are chapters on the care of the dying, admission and discharge procedures, amenities and recreation, and avoidable noise.Inpatients today are normally in hospital for a shorter time and their treatment tends to be more intensive and complicated.The report, according to the authors, has taken account of "the emotional and social needs of the patients, together with aspects of the work of the hospital that most closely affect their comfort and well-being."
老年人的特应性皮炎
Authors: S. Williamson, J. Merritt, A. De Benedetto
Journal: British Journal of Dermatology (2020)

特应性皮炎(AD,也称为特应性湿疹)是一种慢性复发性皮肤病,影响全世界超过 2.3 亿人。它常见于其他过敏症患者, 包括哮喘和过敏性鼻炎(花粉热), 其可通过瘙痒性皮疹和干燥的刺激性皮肤加以辨认。 大多数患者最初在年轻时出现 AD,但也可能在生命中的以后时间发生。随着老年人口的不断增长, 以及对高品质生活质量的期望, AD 对老年人的影响应该获得一些关注。许多老年患者因皮肤瘙痒和干燥到皮肤科、过敏和初级护理诊所就诊, 而且临床医生缺乏关于这些患者正确诊断和管理的信息。 实际上, 大多数关于 AD 的研究和临床护理指南不包括 60 岁及以上的患者, 此群体独立于年轻成人。这篇来自美国的回顾论文旨在概述衰老过程中自然发生的身体变化,这可能导致老年患者容易罹患 AD。 有趣的是, 许多年龄相关的变化与 AD 的关键特征重叠,例如,皮肤屏障功能减退、损害性炎症及细菌(尤其是葡萄球菌) 感染增加。这项工作旨在更好地了解 AD 的衰老相关性病理生理学(身体内的工作)信息, 并发现知识缺口, 从而开拓新的研究领域, 以便将来进行研究。 This summary relates to the study: 老年人的特应性皮炎:一项关于临床和病理生理学标志的回顾
Syphilis
Authors: G. Marshall Crawford
Journal: New England Journal of Medicine (1950)

Benign Late SyphilisThere has been more interest in geriatrics during recent years, but the index of suspicion of syphilis is relatively low when one is faced with the complaints of older patients. It has been claimed that unsuspected and unadmitted syphilis is not uncommon in old age.115 Syphilis may cause symptoms suggesting any known disease, including the chronic illnesses to which the aged are more susceptible. Serologic tests may be confusing in these situations, especially when the syphilis may be of thirty or forty years' duration and the reagin titer will be low or vacillating from positive to negative . . .
Fatty Acid Content of Cadaver Sera in Fatal Ischemic Heart Disease
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Massachusetts Department of Public Health
Authors: Morton A. Madoff
Journal: New England Journal of Medicine (1969)

AVAILABILITY OF VACCINIA IMMUNE GLOBULIN (HUMAN) IN MASSACHUSETTSThe Division of Biologic Laboratories of the State Laboratory Institute receives many inquiries from physicians interested in obtaining Vaccinia Immune Globulin (Human) for clinical use. This biologic product is not distributed by the Biologic Laboratories but is available under the auspices of the American National Red Cross. It may be obtained locally from the Distribution Center of the Massachusetts Red Cross Blood Program, 314 Dartmouth Street, Boston, Massachusetts, 02116 — telephone: (617) 262–1860. This product is distributed at no charge. It is now an official product licensed by the National Institutes of . . .
Scientific Proceedings&lt;subtitle&gt;Papers Read&lt;/subtitle&gt;
Journal: JNCI Journal of the National Cancer Institute (1950)

Scientific Proceedings: Papers Read Get access JNCI: Journal of the National Cancer Institute, Volume 10, Issue 6, June 1950, Pages 1341–1381, https://doi.org/10.1093/jnci/10.6.1341 Published: 01 June 1950