tbuckley/cabot-search huggingface dataset:
ANGINA PECTORIS
Authors: E. FLETCHER INGALS
Journal: JAMA (1918)

I do not know of any greater service I can render the fellows of this institute and the public than by considering, from a very intimate acquaintance, the timeworn affection that forms the subject of this article. I cannot hope to add much that is new, but I confidently hope to call attention to vital points that may have been overlooked by some practitioners, though of the highest importance to sufferers from this malady. Just at the beginning of the world war, Sir Clifford Allbutt published an exhaustive work on diseases of the arteries and angina pectoris, in which he presents many arguments against some of the long-accepted views on these subjects. But the very comprehensiveness of the two large volumes places the matter far beyond the time limit of the average practitioner, and almost beyond that of the specialist devoted to diseases of the circulatory organs. A careful study
In Brief
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Cover
Authors: Brian P. Pace
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Enhanced generation of monocyte tissue factor and increased plasma prothrombin fragment12 levels in patients with polycythemia vera: Mechanism of activation of blood coagulation
Authors: Abraham Kornberg, Naomi Rahimi‐Levene, Rivka Yona, Abraham Mor, Eliezer A. Rachmilewitz
Journal: American Journal of Hematology (1997)

Polycythemia vera (PV) is associated with a high incidence of thrombosis. The association of apparent and secondary polycythemia with thrombosis is not clear. It was suggested that activation of the coagulation system contributes to thrombus formation in PV. However, the mechanism of activation is unknown. Monocytes generate a potent tissue factor (TF) upon stimulation with various substances, which is involved in thrombus formation in various disorders. Therefore, we studied the possibility that the factor is involved in the activation of coagulation and thrombus formation also in PV. Unstimulated peripheral blood mononuclear cells (PBMC) from each of the different types of polycythemia expressed weak TF activity (2 U) and antigen (41.4 to 52.9 pg/ml), which were similar to normal controls. Following stimulation with endotoxin, PBMC from normal controls and from apparent and secondary polycythemia showed a 3.9- to 4.5-fold increase in TF, while cells from PV showed a 21-fold increase (P < 0.001). Similar levels were generated by PBMC after treatment of PV and at the spent phase. TF was generated by monocytes but not by lymphocytes. Plasma prothrombin fragment1+2 (F1+2) levels, assayed at the same time, were significantly higher in PV (2.46 nm) compared to normals and apparent and secondary polycythemia (0.22 to 0.32 nm), and were in a significant correlation with monocyte TF activity and antigen levels (r = 0.77, 0.87). The high levels of F1+2 confirm that the coagulation system is activated in PV. The increased capacity of monocytes to generate TF may be responsible for the activation of the coagulation system and thrombus formation. The hypercoagulability state that is induced by this mechanism suggests that long-life oral anticoagulation should be considered once thrombosis has been developed in PV. Am. J. Hematol. 56:5–11, 1997 © 1997 Wiley-Liss, Inc.
Evils of Infusions
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Autologous Transfusion
Authors: George Milles
Journal: JAMA (1971)

<h3>To the Editor.—</h3> In a letter to the Editor (<b>215</b>:1329, 1971), Allen reviews some of the legal implications of transfusions. He did not indicate that the complications and sequelae of homologous transfusions are nonexistent with autologous transfusions. It cannot be emphasized too strongly that the patient is the only source of blood that will guarantee against reactions or transmitted disease. These facts need to be emphasized, since Allen covered much the same subject in the<i>Archives of Surgery</i>(<b>102</b>:122,1971) and there, too, did not mention the advantages of the patient as his own donor.
tooth in the appendix?
Authors: A. F. White
Journal: JAMA (1971)

Dr. Joseph A. Guzzetta: The patient is a 26-year-old white man who was well until about one year prior to admission, when he experienced intermittent episodes of pain in the right lower quadrant of the abdomen. The episodes were characterized by pain and tenderness on the right side of the lower abdomen, without nausea, vomiting, chills, or fever. The pain did not radiate. The medical history was noncontributory. His temperature was 99 F (37.2 C). There was no palpable adenopathy. Results of examination of the chest were normal. Examination of the abdomen revealed tenderness and a diffuse mass in the right lower quadrant, the boundaries of which were indistinct by palpation. Bowel sounds and results of rectal examination were normal. Results of laboratory studies were normal. Roentgenograms of the chest and abdomen were taken on admission. <h3>Discussion</h3> Dr. Laurence L. Robbins: Dr. Land, what is your opinion? Dr. Richard E.
CRIME AND THE NEWSPAPERS.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CHOLERA INTELLIGENCE
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Incorrect Statement.
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medical News
Journal: JAMA (1979)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
From the Food and Drug Administration
Authors: Stuart L. Nightingale
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Comparison of Recombinant Hirudin with Heparin for the Treatment of Acute Coronary Syndromes
Authors: The Global Use of Strategies to Open Occluded Coronary Arteries (GUSTO) IIb Investigators
Journal: New England Journal of Medicine (1996)

Thrombin has a pivotal role in the pathogenesis of acute coronary thrombosis. We compared the clinical efficacy of a potent, direct thrombin inhibitor, recombinant hirudin, with that of heparin (an indirect antithrombin agent) in patients with unstable angina or acute myocardial infarction.
Large Litter Rearing Enhances Leptin Sensitivity and Protects Selectively Bred Diet-induced Obese Rats from Becoming Obese
Authors: Christa M. Patterson, Sebastien G. Bouret, Sunny Park, Boman G. Irani, Ambrose A. Dunn-Meynell, Barry E. Levin
Journal: Endocrine Reviews (2010)

Abstract Because rearing rats in large litters (LLs) protects them from becoming obese, we postulated that LL rearing would protect rats selectively bred to develop diet-induced obesity (DIO) from becoming obese by overcoming their inborn central leptin resistance. Male and female DIO rats were raised in normal litters (10 pups/dam) or LLs (16 pups/dam) and assessed for anatomical, biochemical, and functional aspects of leptin sensitivity at various ages when fed low-fat chow or a 31% fat high-energy (HE) diet. LL rearing reduced plasma leptin levels by postnatal d 2 (P) 2 and body weight gain by P8. At P16, LL DIO neonates had increased arcuate nucleus (ARC) binding of leptin to its extracellular receptors and at P28 an associated increase of their agouti-related peptide and α-MSH axonal projections to the paraventricular nucleus. Reduced body weight persisted and was associated with increased ARC leptin receptor binding and sensitivity to the anorectic effects of leptin, reduced adiposity, and enhanced insulin sensitivity in LL DIO rats fed chow until 10 wk of age. The enhanced ARC leptin receptor binding and reduced adiposity of LL DIO rats persisted after an additional 5 wk on the HE diet. Female LL DIO rats had similar reductions in weight gain on both chow and HE diet vs. normal litter DIO rats. We postulate that LL rearing enhances DIO leptin sensitivity by lowering plasma leptin levels and thereby increasing leptin receptor availability and that this both enhances the ARC-paraventricular nucleus pathway development and protects them from becoming obese.
Inebriety.
Authors: W. P. Howle
Journal: JAMA (1895)

Oran, Mo., Feb. 25, 1895. <h3>To the Editor:</h3> —Is a man who has been confined in prison ten or twelve years and who has not drank a drop of liquor in all these years an inebriate? Thousands of drunkards have been imprisoned, and not allowed to drink, and after a number of years released well, so far as physical appearances would indicate. The extreme scientists may assert that such men are diseased because many, so soon as they are released get drunk. If carelessness for public opinion is indicative of disease, then drunkenness is possibly a disease too. The remedy is rather curious but it is very effective. It "almost hardly ever fails." Prisoners are rarely troubled with this malady after the first day in jail. The remedy that cures this malady in so short a time is rarely used in other diseases. Moral suasion is another effective remedy in
Sclerotherapy plus octreotide versus sclerotherapy alone in the prevention of early rebleeding from esophageal varices: A randomized, double-blind, placebo-controlled, multicenter trial
Authors: Massimo Pkimignani, Bruno Andreoni, Luca Carpinelli, Alfonso Capria, Gabriele Rocchi, Ivano Lorenzini, Carlo Staudacher, Luigi Beretta, Roberta Motta, Roberto DeFranchis
Journal: Hepatology (1995)

Because of its ability to decrease portal pressure, azygos blood flow, and postprandial splanchnic hyperemia, octreotide administration could be effective in reducing early rebleeding in patients undergoing endoscopic variceal sclerotherapy (EVS). We report the results of a trial comparing EVS + octreotide versus EVS alone. Consecutive patients with cirrhosis and endoscopically proven variceal hemorrhage were considered eligible for the trial if hemodynamically stable for at least 24 hours after bleeding stopped. Patients with advanced liver cancer or having received EVS treatment in the past were not enrolled. After enrollment patients were submitted to EVS (day 1); all patients were randomized to receive octreotide, 100 μg three times a day subcutaneously, or an identical placebo, up to day 29; EVS was repeated at days 8, 15, and 29. Fifty-eight patients were randomized to receive either EVS + octreotide (n = 26) or EVS alone (n = 32). The two groups were evenly balanced for sex, age, Child-Pugh class, history of previous bleeding, endoscopic appearance of varices, or treatment received in emergency. Eight of 26 (31%) patients in the EVS + octreotide group rebled, compared with 11 of 32 (34%) in the EVS group. Four of the eight (50%) patients in the former group and 8 of 11 (73%) in the latter, respectively, bled within day 15. There were 10 (38.5%) deaths in the EVS + octreotide group (seven bleeding-related), compared with seven (21.9%) (five bleeding-related) in the EVS group; these differences did not reach statistical significance. Administration of octreotide, 100 μg three times a day, subcutaneously, to patients undergoing EVS for prevention of recurrent variceal bleeding does not decrease the incidence of early rebleeding.
Medical Evidence in Railway Accidents
Authors: J. C. Hall
Journal: BMJ (1868)

BRITISH MEDICAZ 70WRNAL. [March il, i868. was soft and dilatable.He pushed on, sought for the feet of the child in utero, turned, and rescued his patient from impending death.Many years afterwards I was requested to visit, at midnight, a pool woman in a neighbouring village who was suffering from uterine hemor.rhage about six weeks before her expected labour.Thinking it mighi be accidental rather than a!navoidable, I sent my pupil, whom I had carefully lectured on the principles and practice of midwifery, with in.structions how to act in the suppression of an ordinary hxmorrhage.He went, and, by carrying out the usual plans, succeeded in arresting it pro tempore.About a week afterwards, a similar midnight message aroused me from my slumbers.It immediately occurred to me, that the case was probably one of unaavoidable rather than accidental uterine haemorrhage from malposition of the placenta, and that consequently it would be unsafe to send my pupil.The decision was a happy and providential one.The deatlh of the patient might, in all likelihood, have resulted from an opposite course.Accordingly, despite all weariness of the flesh, I went in propria person&; and as I crossed the threshoid of the cottage, I heard the rush of blood, as she lay floating in it in bed.I instantly seated myself by her side, ascertained the presence of the placenta at the os uteri, and the dilatability of the latter; and, after succeeding in my attempt to allay the woman's fears, and inspire courage by holding out her probable safety, if she would but submit to the needful management, I prepared for action.Within five minutes the child was turned, the hxemorrhage arreste(l, and both lives saved.The patient recovered well.From that hour, I never again employed a pupil in cases of midwifery.P.S.The present paper is designed to sul)plement the one which I wrote "On the Indications for Manual Interference and other Agencies in the Treatment of Abortion" (vide BRITISH MEDICAL JOURNAL for July 13th, I867).Both the series of cases challenge the attention more especially ofthe junior members of the profession, both with an eye to their present advantage, and as an example of the value of recording all im- portant cases at the time of their occurrence.I feel how impossible it would be to describe the details of such histories from memory alone, still less to clothe them with the freslness of a living interest.
Dorland's Illustrated Medical Dictionary
Authors: John K. Dirckx
Journal: JAMA (1988)

As little as two or three decades from now, the publication of reference works such as medical dictionaries in book form may virtually cease. The change from printed books to on-line computer services will not only enable editors and compilers to make additions and corrections daily, but free them from the need to exclude valuable material in order to control the sheer bulk of their products. Until that day comes, medical dictionaries will continue to be revised only at intervals of years, and during those intervals the material they contain will grow increasingly stale, and the material they do not contain increasingly conspicuous by its absence. The appearance of a new edition of a major medical dictionary is therefore an event of some moment, raising a number of important questions. Have previous standards of correctness, conciseness, consistency, and comprehensiveness been maintained? Are the very latest terms included, and are the