tbuckley/cabot-search huggingface dataset:
Experimental Lead Nitrate Poisoning: Microscopic and Ultrastructural Study of the Gills of Tench (Tinca tinca, L.)
Authors: V. Roncero, J. A. Vincente, E. Redondo, A. Gazquez, E. Duran
Journal: Environmental Health Perspectives (1990)

A microscopic, ultrastructural, and morphometric study was made of the gills of tench (Tinca tinca, L.) subjected to acute experimental lead nitrate poisoning.Twenty-one adult tench were subjected to poisoning and a further 22 were used as controls.Lesions were characterized by the appearance of edema and epithelial hyperplasia and necrosis, both in cells fonning part of the filtration barrier and in those in the interlamellar space.These processes developed in the course of the experiment, leading to the death of tench after 12 to 15 days of exposure to 75 ppm lead nitrate, at which point the concentrations of lead in the gills had reached their maximum.
THE POSSIBILITIES OF THE MEDICAL DEPARTMENT OF AN ARMY.
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
NEW BLOOD TEST MAY DETECT OVARIAN CANCER EARLY
Journal: CA A Cancer Journal for Clinicians (2002)

cancer, and all causes of death combined associated with higher levels of particulate air pollution.Fine particulates (smaller than 2.5 microns) and sulfur oxides were the two pollutants most clearly associated with the increases in mortality.The risk of lung cancer death increased by eight percent with every ten micrograms of fine particles per cubic meter of air, and death rates for heart disease and non-neoplastic lung diseases increased by six percent.The impact of these two disease categories was to increase the all-cause death rate by four percent for every such increase in fine particulates.The association between particulate air pollution and increased death rates persisted in Cox proportional hazards analyses adjusted for demographic factors (age, sex, race, education, and marital status) and environmental or lifestyle exposures (smoking, alcohol, occupational dust, and diet).
Bacteriuria Again
Journal: BMJ (1971)

Save the Children Fund. Mental Health ResearchWith inflation at its present rate, says the Annual Report of the Mental Health Re- search Fund, each year 20% more money must be raised just to continue the support of a constant volume of research.Projects of high scientific merit are being turned down for lack of funds.Among research currenly receiving support is a study of the biochemistry of schizophrenia at Edinburgh; investigation of infant behaviour at Cam- bridge; and work on psychogenic amenorr- hoea.
Preface
Authors: Richard D. deShazo
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Book Review Treatment of Some Common Diseases (Medical and Surgical) . By various authors. Edited by T. Rowland Hill, M.D. (Lond.), M.R.C.P. (Lond.). 8°, cloth, 398 pp., with 90 illustrations, and tables. Baltimore: William Wood &amp; Co., 1939. $5.00.
Journal: New England Journal of Medicine (1940)
Modulation of rat hepatocyte proliferation by bile salts:In vitro andIn vivo studies
Authors: M Barone, A Francavilla, L Polimeno, E Ierardi, D Romanelli, P Berloco, A Di Leo, C Panella
Journal: Hepatology (1996)

In this study, the stimulatory effect of bile salts (BS) was evaluated both In vitro , using hepatocyte primary cultures, and In vivo , in normal and 40% partially hepatectomized rats previously fed on BS- enriched diets for 4 weeks. In vitro results show that conjugated cholate (CA) and chenodeoxycholate (CDCA) augmented proliferative activity in rat hepatocytes cultured in absence of mitogens, whereas conjugated deoxycholate (DCA), and ursodeoxycholate (UDCA) did not have any significant effect. None of these BSs increased significantly the replicative response induced by submaximal concentrations of epidermal growth factor (EGF). In vivo , at the end of dietary treatment all animals fed on CA or DCA but not those fed on either CDCA, or UDCA, or tauroursodeoxycholate (TUDCA) developed cholestatic hepatitis and a burst of damage-induced hepatocyte proliferation. After 40% partial hepatectomy (PH), CA- and DCA-treated groups underwent a deterioration of cholestatic hepatitis. On the other hand, in CDCA-, and UDCA-, and TUDCA-treated groups liver histology, serum glutamic pyruvic transaminase (SGPT) and cholestasis indices did not change significantly compared with controls. As far as the proliferative activity, a significant increase was observed not only in CA and DCA but also in UDCA- and TUDCA-fed groups compared with controls, whereas a slight decrease was observed in CDCA-treated animals. In conclusion, our data indicate that conjugated BSs had only a modest stimulatory effect on hepatocyte proliferation In vitro . However, In vivo , in PH rats, UDCA or TUDCA treatment determined a further increase of hepatocellular proliferation not attributable to hepatotoxic effects. Our result suggest that modifications of bile acid pool could modulate hepatocellular proliferation.
Exposure Estimates to Disinfection By-Products of Chlorinated Drinking Water
Authors: Clifford P. Weisel, Hekap Kim, Patricia Haltmeier, Judith B. Klotz
Journal: Environmental Health Perspectives (1999)

Exposure to disinfection by-products (DBPs) of drinking water is multiroute and occurs in households serviced by municipal water treatment facilities that disinfect the water as a necessary step to halt the spread of waterborne infectious diseases. Biomarkers of the two most abundant groups of DBPs of chlorination, exhaled breath levels of trihalomethanes (THMs) and urinary levels of two haloacetic acids, were compared to exposure estimates calculated from in-home tap water concentrations and responses to a questionnaire related to water usage. Background THM breath concentrations were uniformly low. Strong relationships were identified between the THM breath concentrations collected after a shower and both the THM water concentration and the THM exposure from a shower, after adjusting for the postshower delay time in collecting the breath sample. Urinary haloacetic acid excretion rates were not correlated to water concentrations. Urinary trichloroacetic acid excretion rates were correlated with ingestion exposure, and that correlation was stronger in a subset of individuals who consumed beverages primarily within their home where the concentration measurements were made. No correlation was observed between an average 48-hr exposure estimate and the urinary dichloroacetic acid excretion rate, presumably because of its short biological half-life. Valid biomarkers were identified for DBP exposures, but the time between the exposure and sample collection should be considered to account for different metabolic rates among the DBPs. Further, using water concentration as an exposure estimate can introduce misclassification of exposure for DBPs whose primary route is ingestion due to the great variability in the amount of water ingested across a population.
Resource implications and health benefits of primary prevention strategies for cardiovascular disease in people aged 30 to 74: mathematical modelling study
Journal: BMJ (2002)

population as a whole.Overinclusion is acceptable for screening instruments designed for disorders with high mortality rates, particularly as the questionnaire is short and easy to administer.Positive results should be followed by further questioning rather than by automatic referral.The SCOFF questionnaire is efficient at detecting cases of eating disorders in adult women in primary care.We recommend its use by healthcare professionals in primary care.Future work will assess the validity of the questionnaire in other populations, such as adolescents, in whom the prevalence may be higher.
Dealing with sexual problems of cancer patients
Authors: P. Gunby
Journal: JAMA (1981)

The sexual problems of cancer patients are now getting the attention that used to be directed chiefly to the sexual aspects of cardiovascular disease and spinal cord injury. Frank J. Rauscher, Jr, PhD, senior vice-president for science of the American Cancer Society (ACS) and former director of the National Cancer Institute, speaks of the importance of preventing "the ultimate trauma [cancer] from depriving patients of the ultimate joy [of sex]." He expressed annoyance during an ACS seminar in Daytona Beach, Fla, "that we haven't paid more attention to this." However, at the ACS's national conference on gynecologic cancer last October in Los Angeles, George W. Morley, MD, director of gynecologic oncology, University of Michigan Medical Center, Ann Arbor, emphasized consideration of the patient's sexuality in treating cancer of the vulva. For example, he said, the surgeon should preserve the clitoris when possible. Also at that Los Angeles meeting, Melvin J.
CITY CHILDREN DURING THE SUMMER.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Books Received
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical Observations Following Asbestos Exposure
Authors: Arthur L. Frank
Journal: Environmental Health Perspectives (1980)

There is a spectrum of clinical entities following occupational exposure to asbestos. Methods of evaluation for these problems are reviewed. Nonmalignant clinical conditions include asbestos warts, asbestos bodies, parenchymal fibrosis (asbestosis), pleural fibrosis and calcification, and benign asbestotic pleural effusion. Asbestosis, though a benign process, is a significant cause of death. Malignant conditions associated with asbestos exposure include lung cancer, accounting for about 20% of all deaths among insulation workers and significantly related to cigarette smoking. The lung cancers tend to occur more frequently in the lower lobes and are more peripheral. Pleural and peritoneal mesothelioma and some excesses in gastrointestinal cancers are found with asbestos exposure, although these are not related to cigarette smoking. Increased rates of malignancy first become significant after 20 years from onset of exposure and are also related to duration of exposure. Difficulties with the use of death certificate data are reviewed.
The Expanding Scope of Nasal Surgery
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Operative Neurosurgery
Authors: Lester J. Wallman
Journal: JAMA (1970)

The propriety of offering a text on operative surgery is well established. Such books do not encourage "cook book" surgery but rather find their rightful place as aids to the resident who wishes to prepare himself the night before he is to assist at a procedure, and also to the more mature surgeon who can benefit from the opportunity to review the approach to a lesion which he is called upon only occasionally to treat. The third edition of this standard work fulfills the requirements very well. It is authoritative. The operations described have weathered the test of practice in the hospitals of the Wayne State University School of Medicine. Each section opens with a short summary of the pertinent anatomy and physiology. The text is well illustrated and the present reviewer is pleased to find that the original drawings which were so diagrammatic as to be confusing have been
The changing mole
Authors: A. J. Sober
Journal: JAMA (1985)

What should be done about a changing mole? Do all changing pigmented lesions need to be removed? More information is available about change in the setting of malignant melanoma than change in benign nevi. Change is a relatively common event in cutaneous melanoma and has been well studied. The frequencies of certain changes have been correlated with the extent of development. Fifty-five percent of early melanoma (≤0.85 mm in thickness) have had an increase in size and 49% have had a change in color noted by the patient before diagnosis.<sup>1</sup>Bleeding, pain, and ulceration are rarely seen in early melanoma and benign nevi but are significant findings encountered in 63%, 19%, and 50% of advanced primary tumors (≥3.65 mm), respectively. Lesional itching is noted by at least one of four patients with melanoma.<sup>1</sup> Changes occurring in benign nevi have not been as well studied. Because only 1% of
Merkel Cell Carcinoma
Authors: W. Goessling
Journal: Journal of Clinical Oncology (2002)

Article Tools REVIEW ARTICLE Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2002.20.2.588 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 11786590 Merkel Cell Carcinoma Wolfram GoesslingxWolfram GoesslingSearch for articles by this author , Phillip H. McKeexPhillip H. McKeeSearch for articles by this author , Robert J. MayerxRobert J. MayerSearch for articles by this author Show More From the Department of Adult Oncology, Dana-Farber Cancer Institute, and Departments of Medicine and Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA. https://doi.org/10.1200/JCO.2002.20.2.588 First Page Full Text PDF Figures and Tables © 2002 by American Society of Clinical Oncology
Rubella immunisation.
Authors: R Ellman
Journal: BMJ (1979)

ished the average gestational age for detection.5I agree with Dr Jarvis that the early diagnosis of twin pregnancy is a prerequisite for adequate antenatal care and management of delivery.In my opinion ultrasound, if available, is the diagnostic method of choice.With modem technology and with trained operators the method is highly reliable as a screening method.More than one scan should not be necessary-certainly not if twins are suspected and specially sought.With the new real-time scanners it is tempting to make it everyone's tool.However, I wish to stress that ultrasound diagnostics, similar to radiology diagnostics, should be performed by specially educated and trained operators if the method is not to be brought into disrepute.
Tamm-Horsfall glycoprotein links innate immune cell activation with adaptive immunity via a Toll-like receptor-4–dependent mechanism
Authors: Marcus D. Säemann, Thomas Weichhart, Maximilian Zeyda, Günther Staffler, Michael Schunn, Karl M. Stuhlmeier, Yuri Sobanov, Thomas M. Stulnig, Shizuo Akira, Alexander von Gabain, Uwe von Ahsen, Walter H. Hörl, Gerhard J. Zlabinger
Journal: Journal of Clinical Investigation (2005)

Tamm-Horsfall glycoprotein (THP) is expressed exclusively in the kidney and constitutes the most abundant protein in mammalian urine. A critical role for THP in antibacterial host defense and inflammatory disorders of the urogenital tract has been suggested. We demonstrate that THP activates myeloid DCs via Toll-like receptor-4 (TLR4) to acquire a fully mature DC phenotype. THP triggers typical TLR signaling, culminating in activation of NF-κB. Bone marrow–derived macrophages from TLR4- and MyD88-deficient mice were nonresponsive to THP in contrast to those from TLR2- and TLR9-deficient mice. In vivo THP-driven TNF-α production was evident in WT but not in Tlr4–/– mice. Importantly, generation of THP-specific Abs consistently detectable in urinary tract inflammation was completely blunted in Tlr4–/– mice. These data show that THP is a regulatory factor of innate and adaptive immunity and therefore could have significant impact on host immunity in the urinary tract.
Does This Patient Have Appendicitis?
Authors: James M. Wagner
Journal: JAMA (1996)

Appendicitis is a common cause of abdominal pain for which prompt diagnosis is rewarded by a marked decrease in morbidity and mortality. The history and physical examination are at least as accurate as any laboratory modality in diagnosing or excluding appendicitis. Those signs and symptoms most helpful in diagnosing or excluding appendicitis are reviewed. The presence of a positive psoas sign, fever, or migratory pain to the right lower quadrant suggests an increased likelihood of appendicitis. Conversely, the presence of vomiting before pain makes appendicitis unlikely. The lack of the classic migration of pain, right lower quadrant pain, guarding, or fever makes appendicitis less likely. This article reviews the literature evaluating the operating characteristics of the most useful elements of the history and physical examination for the diagnosis of appendicitis.
Experts Air New Findings on Lung Diseases
Authors: J. Stephenson
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal