tbuckley/cabot-search huggingface dataset:
Abstract A1-48: Whole genome expression based drug repurposing
Authors: Paul Geeleher, Steven Bhutra, Jacqueline Wang, R. Stephanie Huang
Journal: Cancer Research (2015)

Abstract Currently, personalizing cancer chemotherapy relies on pathology and more recently molecular biomarker-based approaches. However, as the driving biology is normally not fully understood, the majority of existing biomarkers do not capture a substantial proportion of variability in drug response. This partly explains the commonly observed lack of reproducibility of findings (e.g. from many conventional gene expression signatures) when these markers are applied to new datasets. We developed an approach to predict in vivo drug sensitivity that leverages whole-genome gene expression microarray data and allows the expression of every gene to influence the prediction by a small amount. Our approach builds statistical models from gene expression and drug sensitivity data in a very large panel of cell lines, then applies these models to gene expression data from primary tumor biopsies. In this study, we applied this approach to tumor samples collected in The Cancer Genome Atlas (TCGA). We derived predicted sensitivity for over one hundred drugs in each of the tumor samples. As a proof-of-concept, we demonstrated that a targeting agent (lapatinib) designed against a specific tumor marker (HER2 positive) is indeed predicted to be more sensitive in HER2 positive breast cancers when compared to the other type of cancers. Meanwhile, we identified other agents that exhibit similar or superior sensitivity when compared to commonly prescribed agents in different disease settings. These findings warrant further evaluation of these agents to be repurposed for possible new indications. Interestingly, some of our derived drug sensitivity predictive estimates are correlated with observed survival outcomes in certain cancer patients. When screening all tumor types based on their molecular profiles, we defined several classes of drugs that maybe differentially effective based on tumor molecular profiles. In conclusion, a genome-wide expression drug sensitivity model built in cell lines can be a powerful approach in repurposing drug in cancer treatment. Citation Format: Paul Geeleher, Steven Bhutra, Jacqueline Wang, R. Stephanie Huang. Whole genome expression based drug repurposing. [abstract]. In: Proceedings of the AACR Special Conference on Translation of the Cancer Genome; Feb 7-9, 2015; San Francisco, CA. Philadelphia (PA): AACR; Cancer Res 2015;75(22 Suppl 1):Abstract nr A1-48.
Aplastic anemia and agranulocytosis in patients using methazolamide for glaucoma
Authors: T. P. Werblin
Journal: JAMA (1979)

Carbonic anhydrase inhibitors used in the treatment of glaucoma, seizure disorders, and hypertension are rarely associated with blood dyscrasias. Several case reports of aplastic anemia with use of acetazolamide, and two cases with use of methazolamide, have appeared in the literature. This article describes two cases of aplastic anemia, at least one of which was almost certainly induced by the use of methazolamide, and one case of agranulocytosis related to the use of methazolamide. (<i>JAMA</i>241:2817-2818, 1979)
REDUCED FEES AND INCREASED RISKS.
Journal: JAMA (1995)

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Antimicrobial Therapy
Authors: Luther Pat Rhodes
Journal: JAMA (1977)

<h3>To the Editor.—</h3> The Journalis to be congratulated for presenting the 18 guideline-audits for antimicrobial therapy. The Veterans Administration Ad Hoc Interdisciplinary Advisory Committee on Antimicrobial Drug Usage—Calvin M. Kunin, MD, Chairman (237:1001, 1977) outlined the purposes of the series and invited discussion. I suggest revision for two points: (1) the dosage schedule for meningococcal exposure prophylaxis (237:1134, 1977) and (2) the requirement for dosage modification of the lincosamines in renal failure (237:1003 and 1482, 1977). The recommendation of rifampin, 500 mg daily for five days, is difficult to follow since the drug is currently available in 300-mg preparations. A dose of 600 mg twice daily for two days (or once daily for five days) seems more widely recommended and applicable. The use of minocycline hydrochloride must be reconsidered in light of current evidence of vestibular toxicity. A more convenient schedule might be that presented by Finley.<sup>1</sup> Individual
Blood Simple
Authors: Joan Stephenson
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
JAMA Psychiatry
Authors: Phil Fontanarosa, Annette Flanagin, Brenda Gregoline, Tracy Frey, Kevin Brown, Amanda Ehrhardt, Iris Lo, M Newman, Suzanne Walker, Connie Manno, Sara Billings, Timothy Gray, Paul Ruich, Sam Wilder, Catherine Alden, Stephanie Beckmeyer, Jane Calayag, Jan Clavey, Mary Coerver-Connolly, Paula Glitman, Laura King, Regina Lilly, Rebecca Ritka, Thressa Smith, Donna Thordsen, Carolina Woods, Aggie Zarkadas, Wanda Assistant, Larry Bryant, Jacob Kendall-Taylor, Monica Mungle, Fanny Brown, Anna Bukowski, Lee Calibeo, Lenette Gardner-Gullens, Tosca Hall, Erin Kato, Rachell Lozano, Caroline Sietmann, Angelia Waltower, Michael Berkwits, Eric Butkus, Michelle Kurzynski, Emily Ling, Jesse Mcquarters, Daniel Morrow, Daniella Peting, Reuben Rios, Carrie Butt, Mary Ferkaluk, Karen Bucher, Andy Rekito, Nick Reback, David Song, Deputy Livingston, Thomas Cole, Marla Hall, Deanna Willis, Yolanda Davis, Joseph Thornton, Deanna Bellandi, Jim Michalski, Sara Dibari, Martin Paulus, Helen Simpson, New York, John Torous, Helena Chmura Kraemer, Palo Alto, Howard Bauchner
Journal: JAMA Psychiatry (2019)
Editorial: Analgesic nephropathy or phenacetin poisoning.
Journal: BMJ (1974)

They can also comment on area plans for the Service, in- cluding such things as hospital closures.Hospital waiting lists and visiting times are another legitimate interest and the councils can inspect clinics, health centres, and hospitals as well as look at domiciliary services.This gives their 20 or so members, appointed largely by local authorities and voluntary organizations, quite a powerful voice in the N.H.S.If the profession can make allies of these new bodies then the consequences for the N.H.S. might be surprisingly constructive.But should the councils overplay their inspectorial role then the outcome would be less happy.
THE DRAINAGE CANAL OF CHICAGO.ONE OF THE GREAT SANITARY WORKS OF THE AGE.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE OPHIDIANS.
Authors: JOSEPH JONES
Journal: JAMA (1895)

In the summer of 1851, I began on Colonel's Island, Liberty County, Ga., a series of investigations upon the anatomic and physiologic differences and relations of various animals, and especially of closely related species. These have been continued from time to time in my leisure moments, but the interruptions necessary upon the performance of the practical duties of an arduous and exacting profession, and wholly unavoidable during four years of active service in the Confederate Army, 1861-1865, have prevented the rapid and continuous prosecution, and the desired perfection of these, to me, interesting labors. The preparations which I have dissected, injected and preserved, numbering over two thousand, are at present deposited in the Museum of the Medical Department of the University of Louisiana (now Tulane), and serve as illustrations of some of the results of these investigations. The following measurements and drawings with the accompanying observations are mere fragments of my
Erratum
Authors: John Davis, Franicis Goldsmitb, Griffith Griffiths, John Robinson, Arthur Rudge, Fakenham James, Cummin Toshack, Charles West, Cornwall Gentlemen, Licentiates Thursday, James Crow, Suffolk Gorleston, John Clarke, Frederick Duke, Hastings Philip, William Govett, John Higginbottom, Thomas Hutchinson, James Newnham, Lyme Regis, William Slheppard, Isaac Tucker, Leigh David, Morris Thomascwmamman, Edmund Whitaker, Lancashire Thomas, John Warburton, Joseph Clarke, Robert Collins, James Begbie
Journal: BMJ (1849)
Correction
Journal: BMJ (1962)

of 1.25%.When income tax has been deducted . . .? Let us fce further facts.The Minister seems to envisage a time when no N.H.S. practice will cater for more than 1,500 insured patients.At present rates a practice of 1,500 units brings in about £2,000 a year gross.With the mooted "inducement" it would be £2,037 10s.To me this is a Treasury pipe-dream.Sir, is it or is it not a fact that there is already a shortage of G.P.s, and is it not also a fact that the shortage is likely to become worse ?I suggest that the Minister's advisers have slipped up badly.Already the idea of differential payments (merit awards) for general practitioners has met with much opposition.
Canadian Medical Association Journal, Toronto
Journal: JAMA (1967)

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Mass voluntary immunization campaigns for meningococcal disease in Canada: media hysteria
Authors: S. E. Hume
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Neurogenetic Directory
Authors: James F. Toole
Journal: JAMA (1982)

Here is No. 42 of the epic work in which Vinken and Bruyn have undertaken to assemble the body of knowledge of clinical neurology. This potpourri volume contains much that has already been published elsewhere within the set but in fragmentary form. In the preface is the surprising statement that about one third of all disorders known or suspected to be of genetic origin affect the nervous system. The editors add that most neurologists are unable to use genetic information for the management of their patients owing perhaps to the meager training most have had in this field. By collecting such information in one location, presumably isolated examples of neurogenetic disorders will be brought to the attention of the scientific community so that further cases can be added. This broad subject is covered by limiting each consideration to a page or two of clinical pathological, biochemical, epidemiologic, and genetic characteristics
Breast screening: a response to Dr Maureen Roberts.
Journal: BMJ (1989)

therefore, I believe that breast screening is good for women, though perhaps not for the taxpayer.How I wish, dear Maureen, that I could pursue this cost-benefit argument in friendly conversation with you, as in the past.We must continue the work you did with such dedication to try to control this disease not "brainwashed in the expectation of a dramatic impact" but with realism that screening is the best we can offer at present.It will be a happy day when we can drop the screening programme because a treatment effective against advanced disease has been discovered.
PINCH GRAFT
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Infections with Escherichia coli O157:H7 in Washington State. The first year of statewide disease surveillance
Authors: S. M. Ostroff
Journal: JAMA (1989)

In 1987, Washington became the first state to require that infection with Escherichia coli serotype O157:H7 be reported. In the first year of surveillance, 93 cases were reported, yielding an annual incidence of 2.1 cases per 100,000 population. The median age of case patients was 14 years (range, 11 months to 78 years), with the highest attack rate among children younger than 5 years (6.1 cases per 100,000 population per year). Bloody diarrhea was present in 95% of reported cases, 12% of patients developed either hemolytic-uremic syndrome or thrombotic thrombocytopenic purpura, and one patient died. Suspected secondary cases were seen in 5% of households. Fifty-six (60%) cases occurred during June through September, as did 73% of the cases of hemolytic-uremic syndrome or thrombotic thrombocytopenic purpura. Cases reported during the summer months were more likely than cases reported at other times of the year to be in children younger than 10 years. Medications, including antimicrobial medications, did not influence the duration of symptoms, nor did they appear to alter the risk of developing hemolytic-uremic syndrome or thrombotic thrombocytopenic purpura. This newly established surveillance system in Washington demonstrates that E coli O157:H7 is an important and common cause of bloody diarrhea in the United States.
ACP Journal Club
Authors: Donald P. Warren
Journal: Annals of Internal Medicine (1991)

Letters15 April 1991ACP Journal ClubDonald P. Warren, MDDonald P. Warren, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-114-8-707_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editors:I have readACP Journal Cluband have found it the best summarizing service ever. I shall fall upon it every 2 months.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: 285 17th Street West Vancouver, British Columbia V7V 3S6 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEpistemologga de la Medicina: CCmo saben los mmdicos que lo que saben es verdadero? El saber mmdico en la era del saber inducido por la industria farmaccutica: El caso Vioxx (Medicine's Epistemology: How Do Doctors Know What They Know is True? The Medical Knowledge in the Era of Big Pharma-Induced Knowledge: The Vioxx Case)Risks and Benefits of Evidence in Educational Practice 15 April 1991Volume 114, Issue 8Page: 707-707KeywordsFalls ePublished: 1 December 2008 Issue Published: 15 April 1991 PDF downloadLoading ...
Centrifugal Analysis.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Psychiatric Ethics
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ovarian cancer
Authors: G. S. Richardson
Journal: JAMA (1993)

In this issue of<i>JAMA</i>, the article by Hand et al<sup>1</sup>gives us the opportunity to inspect data drawn not from a specialized referral center but from many Illinois hospitals representing 72% of all cases of ovarian carcinoma reported in the state. It is interesting that the study's results are in accordance with data collected from many major centers around the world. Actuarial 5-year survival rates of patients in the study by Hand et al with stage I, II, and III disease are 77%, 62%, and 24%, respectively, with 55% for all three combined, compared with 79%, 57%, 23%, and 55%, respectively, for the international figures.<sup>2</sup>Neither of these sets of data excludes patients with borderline tumors (ie, tumors of low malignant potential). See also pp 1119 and 1123. The 37% of patients with stage I, II, and III disease who were surgically staged and more completely resected