tbuckley/cabot-search huggingface dataset:
Stentocarditis
Authors: Benno J. Rensing, Robert Jan van Geuns, Maarten Janssen, Matthijs Oudkerk, Pim J. de Feyter
Journal: Circulation (2000)

T he patient was a 67-year-old man who had received 3 single venous aortocoronary bypass grafts in 1978.He remained free of symptoms until mid-1998, when he was admitted with unstable angina.Angiography revealed severe stenoses in the vein grafts to both the right coronary artery (RCA) and the obtuse marginal (OM) branch of the circumflex artery.Three stents were successfully implanted in the OM graft, and 1 stent was implanted in the graft to the RCA.The postprocedural course was uneventful, and the patient was discharged the next day.Four days later, however, he was readmitted with high fever, chills, and malaise.Blood cultures were repeatedly positive for Staphylococcus aureus, and treatment with intravenous antibiotics was begun.During admission, he developed chest pain, with minimal STsegment depression in the inferolateral ECG leads.Creatine phosphokinase levels rose to 1500 IU/L (normal Ͻ240 IU/L).An extensive search for the source of the infection was negative.We decided to perform an electron-beam tomographic (EBT, or ultrafast CT) examination of the thorax to look for a pulmonary, mediastinal, or cardiac source for the infection and to check bypass graft patency.
Colorectal cancer.
Authors: R. H. Begent
Journal: BMJ (1992)

White indurated base of a solitary rectal ulcer viewed through a proctoscope. ManagementOther anorectal abnormalities are excluded by anorectal examination.Biopsy specimens of solitary rectal ulcers show characteristic fibromuscular obliteration of the lamina propria.Constipation is treated and patients are advised to avoid excessive straining at stool.Many agents, including topical steroid enemas, have been used but none significantly affects the course of the disease.Surgery is usually unrewarding, but some doctors advocate rectopexy if there is evidence of abnormal descent.Symptoms tend to be intermittent and usually little more than a nuisance.Occasionally profuse haemorrhage may occur, which may necessitate urgent excision of the rectum. Proctalgia fugaxTreatment of proctalgia fugax * Explanation and reassurance * Analgesics * Antispasmodics * Glyceryl trinitrate * Puborectalis stretchProctalgia fugax is a benign condition that usually affects young men with anxiety.It is often familial and is characterised by attacks of pain in the rectum, perineum, or urethra, which rise to a crescendo of severe pain, lasting from a few minutes to half an hour.It is not especially related to defecation and often occurs at night, waking the patient up.The pain is spasmodic and responds to smooth muscle relaxants such as nitrates.Treatment, after exclusion of other organic disease, is centred on explaining the symptoms and reassuring patients that there is no serious underlying pathology.Analgesics or glyceryl trinitrate may be tried if necessary, but treatment with drugs is not generally satisfactory.In severe cases the patient should be taught to insert a gloved and lubricated finger into the rectum and stretch the puborectalis which is in spasm, in much the same way as forcibly extending a gastrocnemius in spasm during an attack of cramp.
RELATION OF HYPERPLASIA OF ENDOMETRIUM TO SO-CALLED FUNCTIONAL UTERINE BLEEDING
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Immunology
Authors: Philip Anderson
Journal: JAMA (1985)

In its beginnings, immunology was a part of bacteriology, deriving its first renown from the control of epidemic diphtheria. Such simplistic immunology is far behind us. The new connection is to biochemistry and cytology. The new concept of immunity is of a physiological system, akin to the nervous system, more a means of humoral regulation and cellular control than a defensive device activated by illness to clear away bacteria. An important subject in modern immunology is the anatomy and function of the cell membrane, where much of the work of the immune system is done. Immunologists are foremost in the study of glycoproteins, glycans, and other slimes and mucins so crucial to living cells. This up-to-date textbook teaches the new viewpoints for the scholarly undergraduate biologist. It is carefully planned for classroom use and to meet simple teaching objectives, one by one. Because these books are over simplified, they may
THE NEW EDITOR, ASSISTANT EDITOR, AND EDITORIAL BOARD
Authors: DWIGHT L. WILBUR
Journal: Annals of Internal Medicine (1961)

Editorials1 April 1961THE NEW EDITOR, ASSISTANT EDITOR, AND EDITORIAL BOARDDWIGHT L. WILBUR, F.A.C.P., Chairman Committee on PublicationsDWIGHT L. WILBUR, F.A.C.P., Chairman Committee on PublicationsSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-54-4-831 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe Annals of Internal Medicine, The American College of Physicians, and Maurice Pincoffs seemed inseparable. When, after 27 years as Editor of the ANNALS, Dr. Pincoffs announced his anticipated retirement at the end of August, 1960, the Board of Regents faced a most difficult taskin choosing his successor. Maurice Pincoffs had been all the things an outstanding editor should be: a man with a scientific and judicial mind, an able clinician, an outstanding teacher, and an expert in telling a story. He brought the ANNALSto its eminence in scientific reporting and in circulation, and with this achievement came... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByIn Memoriam: J. Russell Elkinton, MD, MACP, FRCP(L); 1910–2002; Editor, Annals of Internal Medicine, 1960–1971Edward J. Huth, MD, Editor Emeritus 1 April 1961Volume 54, Issue 4Page: 831-834 Issue Published: 1 April 1961 PDF DownloadLoading ...
A new era for tuberculosis?
Authors: None The Lancet Global Health
Journal: The Lancet Global Health (2018)

In his keynote speech at this year's Consortium of Universities for Global Health meeting in March, the former UN Secretary-General's Special Envoy for HIV/AIDS in Africa, Stephen Lewis, delivered a blistering attack on the global response to tuberculosis. Citing it as one of three glaring examples of the consequences of inequalities worldwide (the others being climate change and conflict), he pointed to the 280-fold difference in tuberculosis incidence between Canadian Inuits and the non-Indigenous Canadian-born population, and to the "callous starvation" of funding for multidrug-resistant (MDR) disease in India despite the country's massive burden.
TRAUMATIC ARTERIO-VENOUS ANEURYSMS OF THE SUBCLAVIAN VESSELS, WITH AN ANALYTICAL STUDY OF FIFTEEN REPORTED CASES, INCLUDING ONE OPERATED UPON.
Authors: RUDOLPH MATAS
Journal: JAMA (1902)

<h3>OPERATION.</h3> On Sept. 13, 1900—the ninth day after injury—after all preparations had been completed, and with the valuable assistance of Drs. H. B. Gessner, S. M. D. Clark, John Smyth, U. Maes, and Dr. Power, who acted as recorder, the operation was undertaken. The operation was begun at 9:20 a. m., and it was 2:30 p. m.—nearly five hours—before the patient was taken back to his bed, though the actual operative work did not consume three hours. Much of the time was consumed in giving the patient periods of rest, especially during the local anesthesia stage of the operation. During these rest periods, as is often done in tedious operations under local anesthesia, the patient was given freely of ice water, panopepton, toddy, and even beef tea, all of which he enjoyed immensely, and helped him greatly to control himself. Even after chloroform had been administered he was never fully
Error in Text in: Effect of Adjuvant Chemotherapy With Fluorouracil Plus Folinic Acid or Gemcitabine vs Observation on Survival in Patients With Resected Periampullary Adenocarcinoma: The ESPAC-3 Periampullary Cancer Randomized Trial
Journal: JAMA (2012)

Effect of Adjuvant Chemotherapy With Fluorouracil Plus Folinic Acid or Gemcitabine vs Observation on Survival in Patients With Resected Periampullary Adenocarcinoma: The ESPAC-3 Periampullary Cancer Randomized Trial
DOGS IN WAR.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SOUTHERN SURGICAL AND GYNECOLOGICAL ASSOCIATION.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE EXAMINATION OF SCHOOL CHILDREN'S EYES.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ten-Year Experience of Chordal Replacement With Expanded Polytetrafluoroethylene in Mitral Valve Repair
Authors: Junjiro Kobayashi, Yoshikado Sasako, Ko Bando, Kenji Minatoya, Kazuo Niwaya, Soichiro Kitamura
Journal: Circulation (2000)

Background —Mitral valve repair is the procedure of choice to correct mitral regurgitation (MR). Although chordal replacement with expanded polytetrafluoroethylene (ePTFE) has been widely accepted to repair anterior mitral prolapse and other difficult situations, the long-term results of the repair and the fate of ePTFE have not been delineated. Methods and Results —From July 1988 to April 1999, 74 patients (49 males, 25 females) aged 17 to 77 years (mean age 55.3±14.8 years) underwent mitral valve repair with chordal replacement with ePTFE. The follow-up period was from 6 months to 11.3 years (mean 4.6±3.2 years). The causes of MR were degenerative in 65 patients (88%) and infective in 9 (12%). Three patients had active infective endocarditis. Valve lesions were anterior in 35 patients, posterior in 10, and both anterior and posterior in 29. Various procedures for plasty of leaflets were necessary in 37 patients (50%). Atrial fibrillation was associated in 38 patients (51%), and the maze procedure has been performed in a selected group of 30 patients (41%) since July 1992. There was 1 in-hospital death (1.4%) and 3 late cardiac deaths (4.1%). More than moderate MR developed in 12 patients (17%) during the follow-up period. Three of these patients required early reoperation within 1 year due to hemolysis. Two patients underwent mitral valve replacement at 6 and 8 years after repair, respectively. The actuarial reoperation-free rates at 5 and 10 years were 94.3±2.8% and 81.7±9.1%, respectively. Sinus rhythm was restored in 21 patients (70%) with the maze procedure. There was only 1 thromboembolic episode (0.3%/patient-y) in a patient with atrial fibrillation who did not undergo the maze procedure. Event-free survival rates as assessed by the freedom from cardiac death, thromboembolism, reoperation, and anticoagulation-related hemorrhage at 5 and 10 years were 91.3±3.4% and 71.6±9.7%, respectively. There was no relationship between recurrent MR and the change of ePTFE. Structural analysis of the ePTFE resected during reoperation revealed no calcification and showed remaining flexibility and pliability. Protein infiltration was observed in the ePTFE, and collagenous proliferation was recognized at the site of fixation to the valve leaflet and the papillary muscle. The surface of the ePTFE was completely endothelialized, which may induce antithrombogenicity. C onclusions —The long-term durability and biological adaptation of ePTFE as artificial chordae for mitral valve repair of MR were proved for &gt;10 years.
Elevated Putamen D&lt;char aid="99821877" id="sub"&gt;2&lt;/char&gt; Receptor Binding Potential in Major Depression With Motor Retardation: An [&lt;char aid="99821878" id="sup"&gt;11&lt;/char&gt;C]Raclopride Positron Emission Tomography Study
Authors: Jeffrey Meyer
Journal: American Journal of Psychiatry (2006)

Objective: Several antidepressants raise striatal dopamine, but the role of striatal dopamine during major depressive episodes is unclear. Striatal [ 11 C]raclopride binding potential measured with positron emission tomography is an index of D 2 type receptors and is sensitive to extracellular dopamine levels (higher D 2 binding potential occurs when dopamine is lower). It was hypothesized that putamen D 2 binding potential would be higher during major depressive episodes featuring motor retardation. Method: Drug-free, nonsmoking subjects experiencing a major depressive episode (N=21) underwent [ 11 C]raclopride PET imaging as did 21 healthy age-matched comparison subjects. Motor retardation was measured with the finger tapping test. Results: The depressed subjects exhibiting motor retardation had significantly higher D 2 binding potential in both the left and right putamen than did healthy subjects, and putamen D 2 binding potential correlated significantly with motor speed in the depressed subjects. Conclusions: The results argue that extracellular dopamine is lower in subjects experiencing a major depressive episode that features motor retardation. This depression subtype should preferentially benefit from dopamine-increasing medications and should be targeted in future clinical trials of dopamine reuptake inhibitors.
Pulmonary Medicine
Authors: Thomas L. Petty
Journal: JAMA (1987)

In 1987, the prevention of chronic pulmonary disorders remains a major challenge.<sup>1</sup>But to organize effective preventive therapy or treatment of early stages of disease, an understanding of disease mechanisms is required. Recent studies indicate that proteolytic and/or oxidative mechanisms insidiously damage alveoli and small airways and finally result in chronic obstructive pulmonary disease (COPD).<sup>2</sup>This pathogenetic mechanism has been well established for emphysema associated with inherited α-antiprotease deficiency states,<sup>2</sup>and similar pathogenetic processes may be active in adult respiratory distress syndrome<sup>3</sup>and lung cancer. Attempts at therapy have been initiated. Newly completed animal studies, for example, show that emphysema experimentally produced by human elastase derived from polymorphonuclear leukocytes can be ameliorated by intratracheal instillation of an antiprotease, eglin-c, produced by recombinant DNA technology. The antiprotease offered protection with no evidence of bronchial toxic reactions.<sup>4</sup>Clinically, augmentation of α-antiprotease levels in antiprotease-deficient individuals has been
CORRIGENDA.
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Highlights
Journal: JAMA Psychiatry (2018)

Very Low-Nicotine Cigarettes and Cigarette Consumption 995The US Food and Drug Administration is considering limiting cigarettes to very low nicotine levels, but it is not known how such a change would affect nondaily smokers' behavior.Shiffman and colleagues randomized 238 such participants to their own brand of cigarettes or very low-nicotine-content ones and found that the latter was associated with a significant reduction of 1.6 cigarettes per day consumed without a change in abstinence rates.Thus, very low-nicotine-content cigarettes reduce consumption without increasing quitting.In an Editorial, Hatsukami discusses implications for the field.
Donor Statin Treatment Protects against Severe Acute Graft-Versus-Host Disease After Related Allogeneic Hematopoietic Cell Transplantation.
Authors: Marcello Rotta, Barry E Storer, Rainer F Storb, Paul J Martin, Shelly Heimfeld, Amanda Peffer, Brenda M Sandmaier, David G Maloney, H. Joachim Deeg, Frederick R Appelbaum, Marco Mielcarek
Journal: Blood (2009)
East River Greenway, New York City
Journal: JAMA Internal Medicine (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
THE KEELEY CURE INSTITUTES.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal