tbuckley/cabot-search huggingface dataset:
Plasma tissue factor antigen levels in capillary whole blood and venous blood: Effect of tissue factor on prothrombin time
Authors: Emmanuel T. Quien, Enid Morales, Laura A. Cisar, Hugh C. Kim, Catherine Cimini, Parvin Saidi, Claire S. Philipp
Journal: American Journal of Hematology (1997)

To measure the amount of tissue factor released during specimen collection and its potential effect of shortening the prothrombin time, we measured tissue factor and prothrombin time in twenty-three paired venous and capillary blood samples from anticoagulated patients and in ten paired samples from controls. We also compared venous prothrombin time determined by a plasma-based assay with venous and capillary prothrombin time determined with a whole blood assay. Venous specimens were obtained using a two-syringe technique; capillary specimens were obtained by fingerstick after wiping the first drop of blood. Plasma tissue factor was determined by an enzyme-linked immunoabsorbant assay. The patients' mean venous tissue factor (235 ± 101 pg/ml) and capillary tissue factor (268 ± 106 pg/ml) were higher than those of the controls (161 ± 42 pg/ml and 187 ± 63 pg/ml, respectively, P < 0.05). These differences disappeared after adjusting for age. Capillary tissue factor levels were higher than venous tissue factor (244 ± 102 pg/ml vs. 213 ± 93 pg/ml), with a mean difference of 31 pg/ml (P = 0.0001). In addition, whole blood prothrombin time was lower in the capillary than in the venous samples (17.7 ± 5 sec vs. 18.3 ± 5.4 sec, P = 0.004). However, there was no correlation between capillary-venous differences in tissue factor and capillary-venous differences in the whole blood prothrombin time. Whole blood capillary and venous prothrombin times highly correlated with the plasma-based venous prothrombin time (r = 0.98, P < 0.0001). These results demonstrate that obtaining blood by fingerstick does not result in a clinically significant release of tissue factor. In addition, we did not observe any interference of plasma tissue factor with the whole blood prothrombin time assay. A direct relationship between tissue factor and age was observed. Am. J. Hematol. 55:193–198, 1997. © 1997 Wiley-Liss, Inc.
HIV co-infection is associated with lower risk of liver cancer after HCV-cure
Authors: Anaïs Corma-Gómez, Juan Macias Sanchez, Francisco Téllez Pérez, Luis Enrique Morano Amado, Antonio Rivero-Juarez, Miriam Serrano, Maria José Riós Villegas, Juan Carlos Alados Arboledas, Francisco J Vera-Méndez, Nicolas Merchante, Marina Villalobos, Ignacio De Los Santos, Paloma Geijo, Dolores Merino, Arkaitz Imaz, Maria José Galindo, Juan Pineda
Journal: Journal of Hepatology (2020)
The new vital sign. Assessing and documenting smoking status
Authors: M. C. Fiore
Journal: JAMA (1991)

AT THE turn of the last century, the American medical community developed a standardized assessment to help clinicians confront the leading cause of death at that time, infectious disease. This assessment, known as vital signs, included temperature, pulse rate, respiratory rate, and, later, blood pressure.<sup>1-3</sup>Over time, the measurement of vital signs became an expected part of every clinic visit and an essential component of the database physicians use to evaluate, diagnose, and treat patients. As we approach the next century, American medicine is challenged by a different cause of illness and death—tobacco use. Cigarettes are now responsible for more than 430000 deaths each year in the United States.<sup>4</sup>As with past epidemics of this magnitude, institutional changes in the practice of medicine must be adopted to overcome the enormous disease burden resulting from tobacco use. Making smoking status the "new vital
Absorption and Distribution of Xenobiotics
Authors: Frank G. Standaert
Journal: Environmental Health Perspectives (1988)

Extrapolation of pharmacokinetic data between species has been simplified by the advent of more sensitive methods of analysis of chemicals in body tissues and by the capability of inexpensive computers to perform complex calculations. These new methods enable investigators to observe the rates at which target tissues reach equilibrium in different species and to develop mathematical models of these processes. The evaluation of physiological pharmacokinetics from classical or compartmental kinetics is improving the ability to project the long-term behavior of chemicals in body fluids and organs based on independently derived physical, chemical, and physiological constants obtained from simple chemical reactions, tissue culture experiments, or short-term animal studies. Accurate prediction of chemical behavior by such models gives support to hypothetical mechanisms of distribution and accumulation, while significant deviations from predicted behavior signal the existence of previously unsuspected pathways. These techniques permit the simulation of the impact of linear, nonlinear, and saturation kinetics on chemical behavior; the prediction of integrated tissue exposure; and the mapping of the sequence of alternate metabolic pathways that lead to toxicity or detoxification. The discussion will identify the research needs for improving extrapolations between species.
Erratum: RUNX1 mutations in acute myeloid leukemia are associated with distinct clinico-pathologic and genetic features
Authors: V I Gaidzik, V Teleanu, E Papaemmanuil, D Weber, P Paschka, J Hahn, T Wallrabenstein, B Kolbinger, C H Köhne, H A Horst, P Brossart, G Held, A Kündgen, M Ringhoffer, K Götze, M Rummel, M Gerstung, P Campbell, J M Kraus, H A Kestler, F Thol, M Heuser, B Schlegelberger, A Ganser, L Bullinger, R F Schlenk, K Döhner, H Döhner
Journal: Leukemia (2016)
Association between oral contraceptives and myocardial infarction. A review
Authors: H. W. Ory
Journal: JAMA (1977)

Analysis of the association between oral contraceptive use and the development of myocardial infarction in women less than 50 years of age shows that cigarette smoking is the most important factor in increasing the likelihood of myocardial infarction. This effect is independent of oral contraceptive use but oral contraceptive use also appears to be a risk factor; however, their use in the absence of other predisposing factors appears to have only a small effect on increasing the risk of dying from myocardial infarction. This small increase is of the same order of magnitude as the increased risk of death from thromboembolic disease. Oral contraceptive users more than 30 years of age who have other factors that increase the likelihood of myocardial infarction appear to have a substantially higher death rate. (<i>JAMA</i>237:2619-2622, 1977)
A human immunodeficiency caused by mutations in the PIK3R1 gene
Authors: Marie-Céline Deau, Lucie Heurtier, Pierre Frange, Felipe Suarez, Christine Bole-Feysot, Patrick Nitschke, Marina Cavazzana, Capucine Picard, Anne Durandy, Alain Fischer, Sven Kracker
Journal: Journal of Clinical Investigation (2015)

The authors recently identified an error in the identification numbers assigned to patient samples that resulted in an incorrect clinical and immunological description of patient 4 (P4).The error did not affect the conclusions of the manuscript; however, the correct immunological profile is now included in the revised version of Table 1, which appears below.
一项探究长期使用生物制剂（包括停药后重新开始使用）对银屑病患者是否安全有效的研究
Journal: British Journal of Dermatology (2020)

银屑病是一种慢性疾病，可引起皮肤瘙痒、鳞屑状斑块。全世界有多达 3% 的人受银屑病困扰。中度至重度银屑病患者可能会使用注射药物，称为生物制剂。然而，银屑病患者可能需要长期用药，因此了解生物制剂是否可有效清除皮损且能够长期安全使用至关重要。此外，银屑病患者有时会停药一段时间后重新开始治疗，因此了解生物制剂是否能够在治疗中断一段时间后仍能保持皮损清除效果也很重要。
The continuing challenge of preterm delivery
Authors: M. M. Adams
Journal: JAMA (1995)

Each year in the United States, approximately 31000 fetuses die before delivery and 22 000 newborns die during the first 27 days of life. Approximately 71% of fetal deaths and 74% of neonatal deaths occur among preterm infants (&lt;37 weeks' gestation). The rate of severe morbidity is several times higher for preterm survivors than infants born at term.<sup>1</sup>Because of the increased risks for death and morbidity associated with preterm delivery, its prevention is an important public health goal. Yet the rate of preterm delivery in the United States did not decrease during the 1980s. See also p 709. Wilcox and colleagues<sup>2</sup>conclude that an excess rate of preterm delivery in the United States, compared with Norway, accounts for excess perinatal mortality. This conclusion is supported by previous comparisons of the two countries in which a higher percentage of very low-birth-weight infants (&lt;1500 g), nearly all of whom
Commentary
Authors: Michael Dooley
Journal: British Journal of Sports Medicine (2001)

Objective-Synchronised swimming is a sport that shares certain characteristics with other aesthetically pleasing sports such as gymnastics and dance.The purpose of this investigation was to ascertain whether the highest ranked synchronised swimmers in the United Kingdom experience menstrual abnormalities, a common medical problem seen in these related activities.Methods-Twenty three members of the Great Britain synchronised swimming squad completed a questionnaire on menstrual history.Body composition and VO 2 MAX were measured in the laboratory during regular physiological screening.Results-Three of the 23 subjects were oligomenorrhoeic and none were amenorrhoeic.All were postmenarchal.Mean estimated body fat percentage was 23%, and mean VO 2 MAX was 47.2 ml/kg/min.Conclusions-It appears that synchronised swimmers in the United Kingdom are relatively protected from menstrual disturbances for reasons that cannot be explained in isolation.
<i>Announcement</i>: Diabetes Alert Day — March 22, 2016
Journal: MMWR Morbidity and Mortality Weekly Report (2016)

March 22 is Diabetes Alert Day, dedicated to raising awareness about type 2 diabetes, its risk factors, and its prevention.Type 2 diabetes, which accounts for 90%-95% of all cases of diagnosed diabetes in U.S. adults, might be prevented through lifestyle changes, such as losing weight and increasing physical activity (1,2).In the United States, 86 million adults have prediabetes, putting them at increased risk for developing type 2 diabetes, heart disease, and stroke.Only 10% of adults with prediabetes know they have it (1,3).In partnership with the Ad Council, the American Diabetes Association, and the American Medical Association, CDC's Division of Diabetes Translation developed and launched the first national prediabetes awareness campaign to encourage people to take steps to prevent type 2 diabetes.The website DoIHavePrediabetes.org(https://doihaveprediabetes.org) features a short test for people to find out their prediabetes risk and includes lifestyle tips and links to CDC-recognized prevention programs across the country that are part of the National Diabetes Prevention Program (http://www.cdc.gov/diabetes/prevention/index.html).The U.S. Diabetes Surveillance System includes an updated Diabetes State Atlas (http://www.cdc.gov/diabetes/data) that allows users to view data and trends on any mobile device.In addition to containing the latest state-level data, the atlas now presents estimates of the percentage of adults without diagnosed diabetes who report having had a test for diabetes or high blood glucose in the past 3 years.Additional information about diabetes prevention and control is available from CDC (http://www.cdc.gov/diabetes).
Treatment of phencyclidine intoxication
Authors: E. F. Domino
Journal: JAMA (1979)

<h3>To the Editor.—</h3> The letter by Maurice S. Albin, MD (240:529,1978), deserves further comment in view of the widespread abuse of phencyclidine hydrochloride. Severe intoxication from phencyclidine and its congeners induces coma and respiratory, cardiovascular, and renal complications.<sup>1</sup>The latter are secondary to rhabdomyolysis<sup>2</sup>resulting from an interaction of phencyclidine, skeletal exertion, and limb restraints, which should not be used. We have been unable to show any global improvement using tetrahydroaminoacridine or another cholinesterase inhibitor, physostigmine, in dogs severely poisoned with phencyclidine (unpublished data, 1979). In patients poisoned with phencyclidine, I recommend the use of urine acidification and symptomatic therapy maintaining vital functions in cases of severe overdose.<sup>3</sup>Because phencyclidine has a pK<sub>a</sub>of 8.5 to 9.5, 3 pH units lower (5 to 6) will allow most of the phencyclidine in the urine to remain ionized and hence not be reabsorbed by the renal tubules. Although
The House of Delegates
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 578: Investigation of the effect of hypoxia on presentation of HPV16-derived antigens - implications for therapeutic vaccine design
Authors: Nitya Mohan, Maria Bonsack, Jonas Förster, Alina Steinbach, Renata Blatnik, Mogjiborahman Salek, Angelika B. Riemer
Journal: Cancer Research (2019)

Abstract Human papillomavirus type 16 (HPV16) is a causal factor of ~50% of cervical cancers, and of ~95% of extra-cervical (other anogenital and oropharyngeal) HPV-mediated cancers. The aim of our group is to develop a therapeutic vaccine against HPV16-induced malignancies. To find optimal vaccine antigens, it is important to assess the effect of the tumor microenvironment on viral antigen presentation. Hypoxia has been reported to regulate HLA class-I expression levels in the context of various tumors. Thus, the aim of the present study was to explore the effect of hypoxia on various components of the antigen processing machinery (APM) in HPV16-positive tumor cells and on the HPV16 E6- and E7-derived HLA class-I epitope repertoire. We are investigating the effect of hypoxia on cervical cancer cells transformed with HPV16 variant lineages (European, Asian-American and African) correlated with differences in oncogenic potential. This is achieved by comparing cells cultured under hypoxia (1.2% O2) or normoxia (21% O2). We investigate E6 protein levels by immunoblotting and HLA-A2 surface expression by flow cytometry. Subsequently, quantitative PCR and immunoblotting are used to assess whether components of the APM are affected by hypoxia. Cervical cancer cell lines transformed by sublineages of the HPV16 European variant (CaSki and SNU17) showed a decrease in E6 protein levels upon hypoxic treatment. HLA-A2 levels were increased in SNU17 cells (HPV16 European Asian prototype), but no change was observed in CaSki cells (European Prototype 2). First qPCR experiments of SNU17 cells showed changes in additional components of the APM at the mRNA level, which still have to be assessed at the protein level. Cell lines transformed by HPV16 variants other than European will be subjected to the same analysis. Potential changes in the HPV16 epitope repertoire will be investigated using a targeted mass spectrometry-based epitope detection strategy established in the lab. These investigations may yield novel insights into HPV16 immune evasion pathways. Furthermore, the identification of epitopes that are presented under both normoxic and hypoxic conditions will provide optimal candidates for therapeutic vaccine design against HPV-induced malignancies. Citation Format: Nitya Mohan, Maria Bonsack, Jonas Förster, Alina Steinbach, Renata Blatnik, Mogjiborahman Salek, Angelika B. Riemer. Investigation of the effect of hypoxia on presentation of HPV16-derived antigens - implications for therapeutic vaccine design [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 578.
Writing and speaking in medicine.
Journal: BMJ (1976)

Advice centre for postgraduate medical educationThe three Councils for Postgraduate Medical Education (in England and Wales, Scotland, and Northern Ireland) are setting up a National Advice Centre to advise doctors on opportunities for postgraduate medical edu- cation and training in the United Kingdom.The centre will bring together several separate agencies at present helping doctors (part- icularly those from overseas).The service will incorporate that provided by the BMA for non-members and that run by the British Postgraduate Medical Federation for overseas doctors.The BMA will continue to advise its own members and those of affiliated organ- isations.The centre,
Statement of Principle
Authors: Elizabeth R. Seaquist, Andrew J.M. Boulton, R. Mack Harrell, George Grunberger, Richard J. Santen
Journal: Endocrine Reviews (2014)

Statement of PrincipleWe, as representatives of scientific organizations devoted to improving health care and advancing research, reaffirm that it is the mission of our respective medical journals to report and disseminate data from scientific investigation, evolving medical care, and innovative treatments.We believe these reports serve to unite basic scientists, clinical investigators, and medical professionals regardless of their country of origin, ethnic group, or political leaning.We believe that these efforts achieve the common goal of advancing scientific discoveries that lead to improved health of people worldwide.On the basis of our goals and principles, our respective journals will refrain from publishing articles addressing political issues that are outside of either research funding or health care delivery.
Response: Re: Age-Specific Evaluation of Primary Human Papillomavirus Screening vs Conventional Cytology in a Randomized Setting
Authors: Maarit Leinonen, Pekka Nieminen, Laura Kotaniemi-Talonen, Nea Malila, Jussi Tarkkanen, Pekka Laurila, Ahti Anttila
Journal: JNCI Journal of the National Cancer Institute (2010)
Integrated analysis of GWAS and mRNA microarray identified IFN-? and CD40I as the central upstream-regulators in primary biliary cholangitis
Authors: Kazuko Ueno Ueno, Yoshihiro Aiba, Yuki Hitomi, Shinji Shimoda, Olivier Gervais, Yosuke Kawai, Minae Kawashima, Nao Nishida, Kaname Kojima, Masao Nagasaki, Katsushi Tokunaga, Minoru Nakamura
Journal: Journal of Hepatology (2020)
Transactions of the Thirty-ninth Annual Meeting of the Illinois State Medical Society
Journal: JAMA (1890)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dyslexia
Authors: Larry Burd
Journal: JAMA (1989)

<h3>To the Editor.—</h3> The recent report on dyslexia by the Council on Scientific Affairs<sup>1</sup>suggests that treatment of persons with dyslexia has outpaced research in etiology and classification. In response to the suggestion that research strategies in those latter areas need modification, we suggest the following strategies: (1) Have the National Institutes of Health fund identification of a core group of persons with dyslexia. These would be identified based on an agreed on set of diagnostic criteria. Each of these persons and their families would then be given an extensive battery of tests, both neuropsychological and biologic. A more effective nomenclature that would identify these individuals by positive and negative findings with less reliance on exclusionary criteria could be developed. (2) After the data (both biologic and neuropsychological) have been collected and analyzed and a syndromal classification system has been proposed by the initial study group, the National Institutes
ENDOXAN ALOPECIA
Authors: GEOFFREY FALKSON, E. J. SCHULZ
Journal: British Journal of Dermatology (1960)

Journal Article ENDOXAN ALOPECIA Get access GEOFFREY FALKSON, GEOFFREY FALKSON Department of Medicine Search for other works by this author on: Oxford Academic Google Scholar E. J. SCHULZ E. J. SCHULZ Section of Dermatology, University of Pretoria, Transvaal Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 72, Issue 8-9, 1 August 1960, Pages 296–301, https://doi.org/10.1111/j.1365-2133.1960.tb13897.x Published: 01 August 1960
Anisocoria from scopolamine patches
Authors: J. A. McCrary
Journal: JAMA (1982)

Incidental discovery of a dilated and fixed pupil in a patient with no clinical evidence of impaired oculomotor nerve function or increased intracranial pressure should suggest the diagnosis of pharmacologic dilation of the pupil. The diagnosis can be confirmed without the need for extensive neuroradiological evaluation by instillation of 0.5% to 1.0% pilocarpine hydrochloride in the affected eye. (<i>JAMA</i>1982;248:353-354)
Medical explorers in Africa
Authors: R. M. Goldwyn
Journal: JAMA (1969)

The physician-explorers of Africa left a unique legacy of achievement and adventure. Their medical training not only provided knowledge useful for their survival but also cultivated the traits of self-discipline and tenacity necessary for their arduous work. One of the earliest medical pioneers to penetrate the interior of Africa was Mungo Park (1771-1806). Having graduated from the University of Edinburgh, he began his unusual career as a surgeon to the East India Company. His first trip was a voyage to Sumatra, and, on his return, he presented new species of fish and plants to the Linnaean Society. Some members of that influential group were so impressed by Park that they arranged for him to replace Major Daniel Houghton, who had died during an unsuccessful search for the source of the Niger River, known to Europeans only by hearsay. Park's account of his own efforts,<i>Travels in the Interior of Africa</i>
Editorial Comment on: Microsatellite Analysis of Voided-Urine Samples for Surveillance of Low-Grade Non-Muscle-Invasive Urothelial Carcinoma: Feasibility and Clinical Utility in a Prospective Multicenter Study (Cost-Effectiveness of Follow-Up of Urinary Bladder Cancer Trial CEFUB)
Authors: Henk G. van der Poel
Journal: European Urology (2008)