tbuckley/cabot-search huggingface dataset:
THE DREYER VACCINE
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Propranolol in the Treatment of Essential Hypertension
Journal: JAMA (1977)

In a series of 450 patients with mild essential hypertension, propranolol alone (P), propranolol plus hydrochlorothiazide (P+T), propranolol plus hydralazine (P+H), and propranolol plus hydrochlorothiazide plus hydralazine (P+T+H) were compared to reserpine plus hydrochlorothiazide (R+T). Comparison was based on reduction of diastolic blood pressures (BP) to below 90 mm Hg and at least 5 mm Hg less than initial BP after six months of treatment. This was achieved in 92% of patients who received P+T+H, 88% taking R+T, 81% receiving P+T, 72% on P+H and 52% taking P alone. The number of drop-outs, morbid events, and terminating side effects were insignificantly different among the various regimens. In this study, P and P+H were less effective, while P+T and P+T+H were as effective as the standard regimen.
Molecular and Functional Analysis of Tumor-Suppressor Genes by Transfection
Authors: Reinhold Schafer, Jaya Iyer, Elsbeth Iten, Arto C. Nirkko, Johannes Balmer, Roman Klemenz
Journal: Environmental Health Perspectives (1991)

The transformed and tumorigenic phenotype of H-ras transfected rat FE-8 cells can be suppressed by cell fusion with normal rat embryo fibroblasts.Transfection into FE-8 cells of DNA prepared from normal human placenta followed by selective elimination of tumorigenic transfected cell clones resulted in the isolation of phenotypically normal revertants.These cells exhibited a fibroblastlike, normal morphology; were anchorage-dependent; and were unable to proliferate in medium with reduced serum concentrations.Their tumorigenicity was also reduced.The suppressed phenotype has been transferred in a second trans- fection cycle.Human repetitive DNA sequences were detected in secondary transfectant DNA.A putative human suppressor gene, designated NTS-1, has been molecularly cloned.Reintroduction of cloned NTS- 1 sequences into FE-8 cells resulted in suppression of the neoplastic phenotype in spite of a high ras expression.
A Practical Medical Dictionary of Words Used in Medicine with Their Derivation and Pronunciation, Including Dental, Veterinary, Chemical, Botanical, Electrical, Life Insurance and Other Special Terms; Anatomical Tables of the Titles in General Use, and Those Sanctioned by the Basle Anatomical Convention; Pharmaceutical Preparations, Official in the U. S. and British Pharmacopœias and Contained in the National Formulary, and Comprehensive Lists of Synonyms.
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Revised classification system for inherited epidermolysis bullosa: Report of the Second International Consensus Meeting on diagnosis and classification of epidermolysis bullosa
Authors: Jo-David Fine, Robin A.J. Eady, Eugene A. Bauer, Robert A. Briggaman, Leena Bruckner-Tuderman, Angela Christiano, Adrian Heagerty, Helmut Hintner, Marcel F. Jonkman, John McGrath, Joseph McGuire, Alan Moshell, Hiroshi Shimizu, Gianluca Tadini, Jouni Uitto
Journal: Journal of the American Academy of Dermatology (2000)
Should NHS mental health services fear the private sector? No
Authors: E. Murphy, P. Sugarman
Journal: BMJ (2010)

The coalition government wants to open up the market in the NHS. <b>Allyson Pollock </b>(doi:10.1136/bmj.c5382) thinks this will result in an impoverished and inequitable service but <b>Elaine Murphy</b> and <b>Philip Sugarman </b>believe mental health services have much to gain
Highlights
Journal: JAMA Dermatology (2018)

Vascular Malformations and Quality of Life 661Vascular malformations (VAMs) are abnormalities in blood vessel morphogenesis with a prevalence rate of 1.2% to 1.5% among children.Patients with VAMs have a lower healthrelated quality of life than the general population, but the factors related to this have been largely unknown.In this systematic review and meta-analysis, Nguyen et al demonstrate that patients with VAMs have more pain and greater mental stress than the general population.Head and neck involvement was particularly problematic because of visibility and influence on sleep functions.Understanding of the type, quality, and location of VAMS will help guide patient care.
Omission of Conflicts of Interest
Authors: Ankur Pandya
Journal: JAMA (2018)

is different from the cost-effectiveness threshold used to decide whether to disinvest from an existing strategy. 6 Every dollar spent on health care has an opportunity cost.This money could have been used to fund underused cost-effective health services, invested in nonhealth sectors such as education or housing, or given back to the public in the form of lower taxes (for publicly funded health care) or higher wages (for employerbased health coverage).As Sacristán implies, the ultimate goal of disinvesting from cost-ineffective (low-value) care is not simply to save money but to reallocate limited resources to maximize population health and well-being.
The Natural Imperfections of the Body and the Limitations of Science
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Procalcitonin-Based Guidelines and Lower Respiratory Tract Infections—Reply
Authors: Philipp Schuetz
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Expanding Uses of the 125I-Labelled Fibrinogen Uptake Test
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Massachusetts Medical Society
Authors: Robert J. Haggerty
Journal: New England Journal of Medicine (1956)

TOXIC HAZARDS*Naphthalene Poisoning†Naphthalene, a derivative of coal tar, is widely used in industry, with little toxic effects. Its ingestion by children, however, may result in a dramatic and occasionally fatal poisoning. The following case report from the Children's Medical Center, Boston, demonstrates the acute hemolytic anemia that this agent may produce:L.G., a 14-month-old boy, was admitted to the hospital desperately ill after a 3-day history of mild diarrhea, temperature of 102°F., vomiting and pallor. Pink urine had been passed on the day of admission. Physical examination revealed gasping respirations, extreme pallor with slight jaundice and a palpable . . .
1985 Annual Meeting of the American Radium SOCiety
Journal: JNCI Journal of the National Cancer Institute (1984)

Journal Article 1985 Annual Meeting of the American Radium SOCiety Get access JNCI: Journal of the National Cancer Institute, Volume 73, Issue 4, October 1984, Page 1003, https://doi.org/10.1093/jnci/73.4.1003-f Published: 01 October 1984
Issue Information ‐ TOC
Journal: Medicinal Research Reviews (2017)

The journal publishes timely critical reviews of topics related to medicinal research, broadly defined, to which the authors have made significant contributions.Appropriate topics include, but are not limited to, the underlying pathophysiology of important diseases and disease vectors; therapeutic approaches to the treatment of various diseases; the properties of molecular targets for therapeutic agents; important new methodologies facilitating the search for therapies; genomics and proteomics; structure-activity correlations of drug series; the development of new imaging and diagnostic tools; drug metabolism; drug delivery; and chemical, pharmacological, pharmacokinetic, pharmacodynamic, and clinical characteristics of important drugs.Reviews are mainly solicited by the editors; however, voluntary contributions are also encouraged.In the latter case, potential authors are asked to contact the Editor-in-Chief with an outline before beginning to write in order to avoid duplication of effort and to ensure suitability of the topic and the level of coverage.
Aversion Therapy
Authors: M. J. Raymond
Journal: BMJ (1964)

<h3>OBJECTIVE</h3> To determine if the presence of a neonatal surgical facility on site has any effect on mortality and morbidity of very premature infants with necrotising enterocolitis (NEC). <h3>DESIGN AND SETTING</h3> Retrospective review of infants of less than 29 weeks gestation cared for in the seven perinatal centres in New South Wales. <h3>PATIENTS</h3> Between 1992 and 1997, 605 infants were cared for in two centres with in house surgical facilities (group 1) and 1195 in five centres where transfers were required for surgical management (group 2). <h3>RESULTS</h3> Although use of antenatal steroids was significantly lower in group 1 centres than group 2 centres (74% <i>v</i> 85% respectively), and the incidence of hyaline membrane disease, pneumothorax, and NEC was higher, mortality was identical (27%). Fifty two (9%) infants in group 1 and 72 (6%) in group 2 of comparable perinatal characteristics and CRIB (Clinical Risk Index for Babies) scores developed radiologically or pathologically proven NEC. The overall mortality of infants with NEC in group 1 was lower but this was not statistically significant (27% <i>v</i> 35%). Significantly more infants with NEC in group 1 had surgery (69%<i>v</i> 39%). There were fewer postoperative deaths in group 1 and more deaths without surgery in group 2. The duration of respiratory and nutritional support and hospital stay for the survivors were similar in the two groups. In a multivariate analysis, shorter gestation was the only factor associated with mortality in infants with NEC; the presence of in house surgical facilities was not. <h3>CONCLUSIONS</h3> There were no significant differences in outcome of premature infants with NEC managed in perinatal centres with or without on site surgical facilities. Early transfers should be encouraged. This finding may have implications for future planning of facilities for neonatal care.
Lectures on the Experimental Investigation of the Action of Medicines
Authors: T. L. Brunton
Journal: BMJ (1871)

ological Action.DIRECT AND INDIRECT ACrION.-Whenany drug is taken up by a structure and acts upon it as curare on the ends of motor nerves, we term this its direct action.But, as all parts of the body are dependent on one another, some other structure may be affected, not by the action of the drug upon it, but by that which it has exerted on the first part.This is its indirect action.Thus, when curare has been given to an animal, it occasionally happens that the nerves going to the respiratory muscles become paralysed before those which go to the extremities.The muscles of respiration then cease to act, the blood is no longer arterialised, carbonic acid accumulates, and, by irritating the nerve- centres, produce convulsions, which cease when the action of the poison extends to other nerves.In this case neither the muscles, the blood, nor the nerve-centres, are acted on directly by the curare.The muscles will contract if stimulated, and, if the lungs be artificially supplied with air, the blood will be arterialised as usual, the convulsions will cease, and life may be preserved.The non-arterialisation of the blood, the occurrence of asphyxial convulsions, and death, are thus due to the indirect action of curare.
AMA Finances
Journal: JAMA (1978)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cost-Effectiveness of Detecting and Treating Diabetic Retinopathy
Authors: Jonathan C. Javitt
Journal: Annals of Internal Medicine (1996)

Letters1 December 1996Cost-Effectiveness of Detecting and Treating Diabetic RetinopathyJonathan C. Javitt, MD, MPH and Lloyd Paul Aiello, MD, PhDJonathan C. Javitt, MD, MPHGeorgetown University Medical Center, Washington, DC 20007.Joslin Diabetes Center, Boston, MA 02215.Search for more papers by this author and Lloyd Paul Aiello, MD, PhDGeorgetown University Medical Center, Washington, DC 20007.Joslin Diabetes Center, Boston, MA 02215.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-11-199612010-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We appreciate Dr. Lambert's interest in our work. However, contrary to his assertion, neither of the issues he raises limits the application of our study results to decision making.Dr. Lambert challenges our assumption that persons with diabetes who lose their sight are as likely to be rehabilitated as visually disabled persons in the rest of the population. He suggests that loss of proprioception and touch sensation associated with diabetes might cause persons with diabetes to value their sight more highly than do those without the disease. Although he presents no data to support this proposition, we can ...REFERENCE1. Javitt JC, Aiello LP, Ferris FL, Canner JK, Chiang YP, Greenfield SR. Preventive eye care in people with diabetes is cost-saving to the federal government: implications for health-care reform. Diabetes Care. 1994; 17:909-17. Google Scholar Author, Article, and Disclosure InformationAuthors: Jonathan C. Javitt, MD, MPH; Lloyd Paul Aiello, MD, PhDAffiliations: Georgetown University Medical Center, Washington, DC 20007.Joslin Diabetes Center, Boston, MA 02215. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRisk factors for having diabetic retinopathy at first screening in persons with type 1 diabetes diagnosed under 18 years of ageOutcomes-Based Reimbursement Policies for Chronic Care Pathways 1 December 1996Volume 125, Issue 11Page: 939KeywordsBlindnessDecision makingDiabetic retinopathyEye diseasesHealth careQuality of lifeTouchVision ePublished: 15 August 2000 Issue Published: 1 December 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Current status of immunotherapy in acute myeloid leukemia
Authors: Marion Subklewe
Journal: HemaSphere (2018)

1Department of Medicine III, University Hospital, LMU Munich, Munich, Germany 2Translational Cancer Immunology, Gene Center, LMU Munich, Munich, Germany This is an open access Abstract Book distributed under the Attribution-NonCommercial-NoDerivs (CCBY-NC-ND), which allows third parties to download the abstracts and share them with others as long as they credit the author and the abstract book, but they cannot change the content in any way or use them commercially. http://creativecommons.org/licenses/by-nc-nd/4.0
Cardiac Autonomic Control Mechanisms in Power-Frequency Magnetic Fields: A Multistudy Analysis
Authors: Charles Graham, Mary R. Cook, Antonio Sastre, Mary M. Gerkovich, Robert Kavet
Journal: Environmental Health Perspectives (2000)

Heart rate variability (HRV), a noninvasive indicator of autonomic control of cardiac activity, is predictive of long-term cardiac morbidity and mortality. Epidemiologic research suggests that occupational exposure to power-frequency magnetic fields may be associated with autonomically mediated cardiac mortality. Results from our laboratory studies of humans exposed to 60-Hz magnetic fields overnight, however, are inconsistent. HRV is altered in some studies but not others. To clarify this, the pooled data from seven studies involving 172 men were analyzed to test specific hypotheses concerning this inconsistency. After analysis, we excluded a) measurement drift or instability over time because HRV was stable under sham-exposed conditions across all studies; b) inadequate statistical power or failure to maintain double-blind controls; c) differences in field intensity (28.3 vs. 127.3 microT) or exposure pattern (intermittent versus continuous) as main effects; or d) the inclusion of individuals sensitive to magnetic field exposure in some studies but not others. Four separate analytic techniques failed to identify a valid subpopulation of sensitive individuals. In some studies, however, hourly blood samples were collected using an indwelling venous catheter. HRV alterations occurred during intermittent exposure in these studies (p < 0.05) but not in similar studies without blood sampling. This result suggests a field interaction with modest arousal or disturbance. Because HRV is tightly coupled to electroencephalographic activity during sleep, these results are physiologically plausible and suggest that HRV alterations during exposure to magnetic fields may occur when accompanied by increases in physiologic arousal, stress, or sleep disturbance.