tbuckley/cabot-search huggingface dataset:
A retrospective analysis of patients with poor-risk germ cell tumor (PRGCT) treated at Indiana University from 2000 to 2010.
Authors: Nabil Adra, Costantine Albany, Daniel Sonnenburg, Yan Tong, Nasser H. Hanna, Lawrence H. Einhorn
Journal: Journal of Clinical Oncology (2013)

4557 Background: PRGCT represents 14% of germ cell tumors, with 2-year PFS of 50%. PRGCT is defined by primary mediastinal non-seminomatous germ cell tumor (PMNSGCT), non-pulmonary visceral metastasis (NPVM), AFP &gt; 10,000 or hCG &gt; 50,000. This analysis attempts to identify subsets of patients with more or less favorable outcomes among the poor risk groups. Methods: Retrospective analysis of all patients with testicular cancer seen at Indiana University (IU) from 2000-2010. 291 patients with PRGCT identified of whom 79 received initial therapy at IU. We analyzed the following variables: primary site testis/retroperitoneal (T/RP) vs. PMNSGCT, pulmonary vs. NPVM, and the amplitude of serum tumor markers. We identified groups of patients according to the level of tumor marker elevation with cutoff points of AFP 20,000 and hCG 200,000. Results: Mean age 29, mean AFP 8,283, mean hCG 185,667. 24% had PMNSGCT, 48% NPVM, 11% AFP&gt;20,000, and 25% hCG&gt;200,000. When hCG was analyzed as a continuous variable, every 10,000 unit increase in hCG caused the hazard of progression to increase by 1% (p value 0.01). Patients with NPVM had significantly worse PFS. NPVM with elevated hCG had worse outcome than NPVM with normal hCG. This did not correlate as well with AFP. PFS was worse with NPVM than elevated pre-chemotherapy tumor markers. Multiple different criteria for poor risk disease carried significantly worse impact on PFS and OS when compared to having a single criterion for poor risk disease. Conclusions: Our data indicate that patients with NPVM or more than one criteria for PRGCT have a worse outcome compared to other PRGCT subgroups. [Table: see text]
GENERAL PRINCIPLES OF HUMAN REFLEXOLOGY. AN INTRODUCTION TO THE OBJECTIVE STUDY OF PERSONALITY. By<i>V. M. Bechterev.</i>English Translation by<i>Emma</i>and<i>William Murphy</i>, from the Russian fourth (1928) edition. (New York: International Publishers, 1933.)
Authors: A. J. R.
Journal: American Journal of Psychiatry (1934)
Errors in Ratings Table
Authors: David Tunkel, Stephanie Jones, Richard Rosenfeld
Journal: JAMA (2016)

We reviewed the guideline rating table in the synopsis, which rated the external review process as fair and the updating process as poor for this guideline.The tinnitus clinical practice guideline, like all guidelines developed by the American Academy of Otolaryngology-Head and Neck Surgery Foundation (AAO-HNSF), followed a defined, published process that includes extensive review as well as plans for updating each guideline in a timely manner. 3he review process for this guideline included internal implementability assessment, external stakeholder review from multiple disciplines, open public comment, and editorial peer review, each of which led to many comments and substantive edits in the draft guideline prior to publication.This tinnitus guideline was published less than 2 years ago, and the document explicitly stated the plan to update in 5 years (unless new literature is published that would change the guideline recommendations).This is consistent with Institute of Medicine standards. 4e suggest that the external review process for the tinnitus guideline be rated as good and the updating process as fair based on the criteria for rating in these types of articles.
ELUCIDATING THE ASSOCIATION OF FRAMINGHAM AND REYNOLDS RISK SCORES WITH INCIDENCE AND PROGRESSION OF CORONARY ARTERY CALCIFICATION IN THE MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS
Authors: Andrew P. DeFilippis, Michael J. Blaha, Matthew J. Budoff, Donald M. Lloyd-Jones, Robyn L. McClelland, Chiadi Ndumele, Susan G. Lakoski, Mary Cushman, Nathan D. Wong, Roger S. Blumenthal, Khurram Nasir
Journal: Journal of the American College of Cardiology (2010)
Tetanus
Authors: A. R. Holder
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Variety=Destiny?
Authors: Joan Stephenson
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medicolegal
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Spermatozoa and Sterility: A Clinical Manual
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Angio-Conray: New Angiographic Contrast Agent
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A twin study of human obesity
Authors: A. J. Stunkard
Journal: JAMA (1986)

Height, weight, and body mass index (BMI) were assessed in a sample of 1974 monozygotic and 2097 dizygotic male twin pairs. Concordance rates for different degrees of overweight were twice as high for monozygotic twins as for dizygotic twins. Classic twin methods estimated a high heritability for height, weight, and BMI, both at age 20 years (.80,.78, and.77, respectively) and at a 25-year follow-up (.80,.81, and.84, respectively). Height, weight, and BMI were highly correlated across time, and a path analysis suggested that the major part of that covariation was genetic. These results are similar to those of other twin studies of these measures and suggest that human fatness is under substantial genetic control. (<i>JAMA</i>1986;256:51-54)
November Rain
Authors: George N. Braman
Journal: Annals of Internal Medicine (2010)

Ad Libitum2 March 2010November RainGeorge N. Braman, MDGeorge N. Braman, MDFrom Bronx, NY 10471-1609.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-152-5-201003020-00011 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail He loved the cold fingertipsOf November rain. I knowHe didn't want to think of deathThat morning when the sun rose shivering,But even when his mind drank inThe walking chill of open airThis icicle was there.He dreaded giving up the smellOf damp summer dawn, the sightOf naked trees barren in the wind,The touching lightly of a woman's thigh(For that alone he was afraid to die).How could I answer thenAs he looked at me with wild eyes?It was not mine but divine graceWhen a drop of rain just touched his face. Author, Article, and Disclosure InformationAffiliations: From Bronx, NY 10471-1609.Current Author Address: George N. Braman, MD, 5903 Liebig Avenue, Bronx, NY 10471-1609. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 2 March 2010Volume 152, Issue 5Page: 323KeywordsDeoxyadenosine monophosphateSmellWalking ePublished: 2 March 2010 Issue Published: 2 March 2010 Copyright & PermissionsCopyright © 2010 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Polychlorinated Biphenyl Induction of Hepatocellular Carcinoma in the Sprague-Dawley Rat
Authors: D. H. Norback, Robert H. Weltman
Journal: Environmental Health Perspectives (1985)

Male and female Sprague-Dawley rats (70 males and 70 females in the initial group) were fed a diet containing a polychlorinated biphenyl mixture (Aroclor 1260, 100 ppm for 16 months and 50 ppm for an additional 8 months) for 2 years followed by a control diet for 5 months. A control group initially consisted of 63 males and 63 females. Sequential morphologic changes were evaluated throughout the study. In the PCB-exposed group the following hepatocellular lesions developed in sequence: centrolobular cell hypertrophy at 1 month, foci of cell alteration at 3 months, areas at 6 months, neoplastic nodules at 12 months, trabecular carcinoma at 15 months, and adenocarcinoma at 24 months. In addition, simple and cystic cholangioma at 18 and 23 months, respectively, and adenofibrosis at 22 months were present. With the exception of hepatocyte hypertrophy and adenofibrosis, all lesions contained cells that were positive for gamma glutamyl transpeptidase activity. In the PCB-exposed group that was examined after 18 months, hepatocellular neoplasms were present in 95% of the 47 females and in 15% of the 46 males. Distant organ metastases did not occur and the mortality rate was not increased in the PCB exposed group. In 81 control rats examined after the 18th month, only 1 hepatocellular neoplasm (a neoplastic nodule) occurred. PCB- exposed and control rats developed simple cholangioma, cystic cholangioma and adenofibrosis; the incidence of each was greater in the PCB group. Thus, within the Sprague-Dawley rat group exposed to a diet with relatively high concentrations of Aroclor 1260 for 2 years a hepatocarcinogenic effect manifested by formation of slowly growing hepatocellular carcinomas was produced.
A Clinical Lecture on the Surgery of the Male Perinaeum and External Organs of Generation
Authors: C. G. Wheelhouse
Journal: BMJ (1886)

Now let me tell you how we used to see the operation performed here in my early days, and you will see how my method grew up in iy mind.A. full-sized silver catheter, or as large a one as the urethra would admit, was passed down to the stricture; then the point was tnrned round, and pressed outward in the perinoeum until it could be clearly and unmistakably felt there.Next, it wa,s cat down upon, annd the urethra was opened upon its point, and thle parts in the middle line were carefully divided, until the point of the catheter could be carried on into the bladder.In this wayi, no douibt, a roa4 of some kind was cleared into the dilated portion of the urethra be- hind the stricture, from which Mr. Cock would have made his start; and happy was the patient in whose case it was effected in any moderate time, anl the catheter was then passed onwards into the bladder.But, gentlemen, I cannot adequately describe to you the difficulty which seemed generally to attend upon this part of the proceed- ing.The very recollection of it is distressing to me now ; and", after all, we had no guarantee that we had really followed the tine course of the urethra through the stricture.Further, we had nothing really to guide us to the distal portion of the urethral tra6k, and the efforts I have seen made to find that have been painful beyond de- scription, and often unsuccessfuil after all.Was it not possible then to think out some means of simplifying this, apparently the crucial difficulty of all?I suppose there were .nogreatei.or more skilful lithotomists in Eng- land than the late Mr. Smith and the late Mr. Teale, and in watching their operations I learned the next step in my own.They were always very careful in their teaching to point out to us the infinite danger accompanying too free division of the prostate ; and Mr.Teale, in order to avoid this, invented a special dilator with which, after he had opened the urethra, and had lightly incised the prostate,
PRIMARY SYSTEMIC AMYLOIDOSIS
Authors: H. J. L. M.
Journal: Annals of Internal Medicine (1953)

ExcerptWhen a clinical syndrome indicates involvement of several systems, the diagnostician thinks of disease processes with a widespread common denominator. The blood and blood vessels permeate every organ in the body; the lymphatic system is widespread; the endocrines, by virtue of their hormones, have far-reaching effects; metabolism is universal; connective tissue is common to all organs and systems; infectious agents can take root far and wide. The clinician therefore considers:(1) blood diseases, such as leukemia, polycythemia, multiple myeloma, sickle cell anemia;(2) vascular diseases, such as atherosclerosis, thromboangiitis obliterans, thrombophlebitis migrans;(3)lymphomatousdiseases, such as Hodgkin's disease, lymphosarcoma,...
Recombinant Human Thrombopoietin in Combination With Granulocyte Colony-Stimulating Factor Enhances Mobilization of Peripheral Blood Progenitor Cells, Increases Peripheral Blood Platelet Concentration, and Accelerates Hematopoietic Recovery Following High-Dose Chemotherapy
Authors: George Somlo, Irena Sniecinski, Anna ter Veer, Jeffrey Longmate, Gaylord Knutson, Stanimir Vuk-Pavlovic, Ravi Bhatia, Warren Chow, Lucille Leong, Robert Morgan, Kim Margolin, James Raschko, Stephen Shibata, Merry Tetef, Yun Yen, Stephen Forman, Dennie Jones, Mark Ashby, Gwen Fyfe, Susan Hellmann, James H. Doroshow
Journal: Blood (1999)
The Potential of Exposure Biomarkers in Epidemiologic Studies of Reproductive Health
Authors: Carol J. Rowland Hogue, Marge A. Brewster
Journal: Environmental Health Perspectives (1991)

1l urthr tbe delopment and ap a ofexposure marker in ffid igons in reproductive epidemiooy, we have synthesizd recent min s ofthe iums sn dng expoe _ in rt ep oductiveeThe specific godds Ofthis pper are to die e e d e le their pkuiel u, ar took The tests for glucaric ad, m idty, and po n p meet the genal criteria for usel ex- posure screens.For certain enobodc agents, the tests ydiferentateposure k , as demonstrated in occuptional and niromental studies.As urinary screens, they are noninvasve and apble on a large scale with current labo techniques For short-term esue, glucaric acid, thloetbers, and mug tests are usefl.Fpyn pattrs may measr cumulative effectsasswell acurrent eqxu klveh The ness ofthese testsin epidemiologic udesofei ental effectson repducthealth ha yet to be studied.'lb do so, the battery must be _ed for pregant wemen, and ts reults must be correlaed with measured adverse ep u comes such as g Inllgh and l ht.Tis a i p il y Im at bece m a e e rater tIu feti exposure isbeingm d Theex eUttowhichIntohtic chemiaiscrooathep barriermqvary greadyt de-pendng on the type of epsues, tming in p and materal Wi better eqre measures, ep studies of halt probably Wm not ci ienobiotic fegotoc* agents in the environment.However, with an adeq battery ofnecf expsre blmarkers, prospective studies of en- vironmental effects on pregnancy outcomes might be possible.lb narrow the lst of potentil exposures, these prospec- tive studies could be foLowed by case-cntrol studies of more specific blomarks dired at upect exposures.
The electrophoresis of human gastric juice: Part II In patients with gastric ulcer
Journal: Gut (1962)

Part II In patients with gastric ulcerAbstract The electrophoretic patterns of the proteins of the gastric juice of a series of patients with gastric ulcer, a control group, and a group of patients with miscellaneous gastric and systemic diseases were studied, autodigestion being prevented by maintaining the pH of the gastric contents above 7. A slow moving anodal band (band 2) was present in 50% of the observations on gastric ulcer patients, whereas this band was present in only 10% of the patients who did not have a gastric ulcer.
Typographic Data Reporting Error
Journal: JAMA Internal Medicine (2014)

Elsayed Z. Soliman, MD, MSc, MS; Monika M. Safford, MD; Paul Muntner, PhD; Yulia Khodneva, MD, PhD; Farah Z. Dawood, MD; Neil A. Zakai, MD; Evan L. Thacker, PhD; Suzanne Judd, PhD; Virginia J. Howard, PhD; George Howard, DrPH; David M. Herrington, MD, MHS; Mary Cushman, MD, MSc
INTERLINGUA
Authors: Giorgio Canuto
Journal: JAMA (1960)

<h3>To the Editor:—</h3> The Journalhas invited comments on the usefulness of its summaries in Interlingua. I was able to understand the summaries because I speak Italian, Esperanto, French, German, a little English, Latin, and other languages. But I am sure that a person who speaks only his mother tongue, especially if this is not a romance language, would be unable to understand such texts. The real problem in this field is not the immediate intelligibility or unintelligibility for persons who already speak several languages; rather, it is how to enable people without knowledge of foreign languages to communicate with each other. That can be done only through a full medium of communication, i. e., by a complete language which can not only be understood when read but can also be easily and freely spoken and written by everybody. Interlingua does not fulfil these requirements. The International Language, known also
Effects of ranitidine on blood alcohol levels after ethanol ingestion. Comparison with other H2-receptor antagonists
Authors: C. DiPadova
Journal: JAMA (1992)

<h3>Objective.</h3> —To determine whether the H<sub>2</sub>-receptor antagonist, ranitidine, which is a potent inhibitor of gastric alcohol dehydrogenase activity in vitro, increases the bioavailability of orally administered ethanol (0.3 g/kg of body weight) and to compare the resulting blood alcohol concentrations with those of two other H<sub>2</sub>-antagonists, cimetidine and famotidine, the latter of which does not inhibit gastric alcohol dehydrogenase. <h3>Design.</h3> —For each of the H<sub>2</sub>-receptor antagonists, a different group of subjects was used. In each group, a paired design was adopted with each subject serving as his own control. <h3>Setting.</h3> —Hospital laboratory. <h3>Subjects.</h3> —Normal, healthy men aged 24 to 46 years. <h3>Intervention.</h3> —Eight men were treated for 1 week with ranitidine (300 mg/d), six with cimetidine (1000 mg/d), and six with famotidine (40 mg/d). <h3>Measures.</h3> —Peak blood alcohol concentrations, areas under the blood alcohol curve, first-pass metabolism, and bioavailability of orally consumed ethanol. <h3>Results.</h3> —Relative to baseline, ranitidine increased the mean peak concentration and the area under the curve of blood alcohol concentrations by 34% (<i>P</i>&lt;.05) and 41% (<i>P</i>&lt;.01), respectively. First-pass metabolism of ethanol was decreased from 70±10 to 31±9 mg/kg of body weight, with a corresponding increase in ethanol bioavailability of 79.6% to 92.6%. By comparison, cimetidine had even a greater effect on blood alcohol levels, while famotidine had no significant effects. <h3>Conclusion.</h3> —Patients treated with ranitidine or cimetidine should be warned of possible functional impairments after consumption of amounts of ethanol considered safe in the absence of such therapy. (<i>JAMA</i>. 1992;267:83-86)