tbuckley/cabot-search huggingface dataset:
Aortoduodenal Fistula
Authors: Joe A. Pinkerton
Journal: JAMA (1973)

A patient had undergone resection of an abdominal aortic aneurysm 12 years earlier in which a synthetic aortic graft was used. An aortoduodenal fistula occurred at the proximal aortic anastomosis where a false aneurysm had developed, and massive gastrointestinal bleeding resulted. In the absence of infection, the existing grafts were salvaged by division of the fistula, resection of the false aneurysm, and replacement with a new synthetic graft. The patient has had an uncomplicated course and remains well six months postoperatively. A high index of suspicion for this problem is urged for any patient with gastrointestinal bleeding who has a synthetic aortic graft.
TREPHINING FOR CEREBRAL HEMORRHAGE.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Book Listings
Journal: Annals of Internal Medicine (2000)

Book Listings18 April 2000Book ListingsSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-8-200004180-00100 SectionsAboutFull Text ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The following materials were received for review from 1 September to 31 October 1999 by Doody Publishing, a book review service based in Chicago.CardiologyHurst's The Heart: Companion Handbook9th edition. RW Alexander, RC Schlant, V Fuster, RA O'Rourke, R Roberts, and EH Sonnenblick, eds. 777 pages. New York: McGraw-Hill; 1998. $32.00. ISBN 0070010242. Order phone 800-262-4729.Management of Complex Cardiovascular Problems: The Consultant's ApproachT Nguyen, D Hu, S Saito, LY Leng, and V Dave, eds. 260 pages. Armonk, NY: Futura; 2000. $45.00. ISBN 0879934417. Order phone 800-877-8761.Obesity: Impact on Cardiovascular DiseaseGF Fletcher, SM Grundy, and L Hayman, eds. ... Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 18 April 2000Volume 132, Issue 8Page: B1KeywordsMicrobiology ePublished: 15 August 2000 Issue Published: 18 April 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.Loading ...
The case of Baby Fae
Authors: O. Jonasson
Journal: JAMA (1985)

Appearing in this issue ofThe Journalis the first full scientific report of the "case of Baby Fae"—cardiac xenotransplantation in a neonate. Many emotional editorial comments about this case have appeared in the lay press and in respected scientific publications. Critical editorial commentary by peers, based on an impartial analysis of the scientific gathering of the facts, is now appropriate. The infant, born prematurely with hypoplastic left heart syndrome, an invariably fatal form of congenital heart disease, received the heart of a young female baboon in an uncomplicated surgical procedure on Oct 26, 1984. At the time of transplantation the infant was critically ill, and urgent surgical intervention was required if she was to survive even for a brief interval. Based on his own evaluation of the alternatives, Dr Bailey had offered xenotransplantation to the mother. The alternatives were three: a risky palliative surgical procedure, the Norwood procedure,<sup>1</sup>
PROFESSOR HUXLEY.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cerebral Vasculitis Associated With Cocaine Abuse
Authors: Brian R. Kaye
Journal: JAMA (1987)

A case of cerebral vasculitis in a previously healthy 22-year-old man with a history of cocaine abuse is described. Cerebral angiograms showed evidence of vasculitis. A search for possible causes other than cocaine produced no results. We now include cocaine with methamphetamines, heroin, and ephedrine as illicit drugs that can cause cerebral vasculitis. (<i>JAMA</i>1987;258:2104-2106)
Bundle-branch block complicating acute myocardial infarction
Authors: S. Scheidt
Journal: JAMA (1972)

Nineteen patients with right bundle-branch block (RBBB) and 20 with left bundle-branch block (LBBB) were treated in a coronary care unit for acute myocardial infarction during a 4 1/2-year period. Twenty-six percent of patients with RBBB developed cardiogenic shock, 32% had complete atrioventricular block, and 26% had ventricular asystole. Mortality was 37%, primarily from myocardial failure rather than asystole or arrhythmia. Pacemaker therapy was generally unsuccessful in reducing mortality. In contrast, 70% of the group with LBBB suffered life-threatening ventricular arrhythmia during or in close proximity to the acute phase of myocardial infarction. Mortality was 35%. Electrophysiologic mechanisms may influence ventricular irritability in patients with LBBB and ischemic heart disease. Consideration should be given to prophylactic antiarrhythmic therapy in these patients at least during hospitalization for acute myocardial infarction.
FRI0291 MRI inflammation and its relation with measures of clinical disease activity and different treatment responses in patients with ankylosing spondylitis treated with a TNF inhibitor:
Authors: P. Machado, R. Landewé, J. Braun, X. Baraliakos, K.-G.A. Hermann, B. Hsu, D. Baker, D. van der Heijde
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Ankylosing spondylitis (AS) is characterized by inflammation in the spine. The relationship between MRI inflammation and measures of clinical disease activity is incompletely understood. <h3>Objectives</h3> To investigate the relationship of MRI inflammation to measures of clinical disease activity and to different treatment responses in patients with AS who were treated with a TNF inhibitor. <h3>Methods</h3> A random 80% sample of the ASSERT database was used for this analysis. ASSERT was a 24-week (wk) RCT comparing infliximab and placebo in patients with active AS, with an open extension until 102wk. MRIs at baseline, wk24 and wk102 were scored by 2 independent readers using the ASspiMRI-activity score. For this analysis, scores were re-coded using the Berlin modification in order to exclude erosions from the scores. Analyses were performed on average scores of the two readers for all patients at baseline, for changes in the infliximab group at 24wk and for changes in all patients at 102wk. Spearman correlation coefficients were determined. Treatment responses according to the ASDAS, BASDAI and ASAS20 were calculated at 24 and 102wk. For each treatment response criterion, subgroups of responders and non-responders changes in MRIa scores were compared using 3 statistical approaches: 1) the standardized mean difference (SMD), 2) the F-score and p-value of a two-sided ANOVA on van der Waerden normal scores, 3) the difference in the standardized response mean (ΔSRM). <h3>Results</h3> At baseline, ASDAS (r=0.16) and CRP (r=0.28) correlated significantly with MRIa scores. Similarly, changes in ASDAS (r=0.22 at 24wk, r=0.23 at 102wk) and changes in CRP (r=0.25 at 24wk, r=0.32 at 102wk) correlated significantly with changes in MRIa scores. Higher baseline ASDAS and CRP values were associated with greater decreases in MRIa scores (ASDAS: r=-0.14 at 24wk, r=-0.15 at 102wk; CRP: r=-0.25 at 24wk, r=-0.31 at 102wk). None of the associations described for CRP and ASDAS were present for BASDAI, individual BASDAI questions and patient global. Differences in MRIa change scores between responders and non-responders were greater when subgroups were defined according to the ASDAS response criterion than when subgroups were defined according to the BASDAI or ASAS20 response criteria (table: changes from baseline to wk102 in MRIa scores, n=179). <h3>Conclusions</h3> MRIa correlates better with CRP than with other measures of disease activity. By including both CRP and patient reported outcomes in its formula, ASDAS has the advantage of providing combined information on objective and subjective measures. As a response measure ASDAS also better reflects the spinal inflammatory disease process in AS than the other frequently used response measures. <h3>Disclosure of Interest</h3> None Declared
Tuberculin conversion
Authors: C. W. Ochs
Journal: JAMA (1967)

The tuberculin response in a crew of nearly 1,000 men on board a US Navy ship was investigated for a one-year period. The incidence of tuberculin conversion was found to be high even though no active tuberculosis was detected. Most of the men manifesting conversion had tuberculin reactions which were weak and highly variable. The reactions were similar to those attributed to atypical mycobacteria in several recently reported studies. Crossreactions from nontuberculous organisms must be considered when evaluating tuberculin test results obtained in the investigation of tuberculosis.
Heterogeneity of combinatorial human autoantibodies against PDC-E2 and biliary epithelial cells in patients with primary biliary cirrhosis
Authors: S Cha
Journal: Hepatology (1994)

The polyclonal nature of antimitochondrial autoantibodies and the limited success of generating human monoclonal antibodies have made analysis of fine specificity and antibody heterogeneity difficult to define. The major autoantigen of primary biliary cirrhosis is the E2 component of the pyruvate dehydrogenase pathway (PDC-E2). To address the relative importance of the region(s) in the PDC-E2 inner lipoyl domain to antibody binding, we report herein detailed profiles of 12 PDC-E2—specific antigen-binding fragments, SP1 through SP12, derived by screening of a combinatorial immunoglobulin library (derived from a primary biliary cirrhosis patient) with full-length native PDC-E2. All antigen-binding fragments are IgG isotypes and include a similar number of λ- and κ-chains. The antigen-binding fragments react specifically to PDC-E2 with high affinity (Ka = 10−7 to 10−10 mol/L−1) and recognize a conformational epitope in the inner lipoyl domain of PDC-E2. Furthermore, the antibodies demonstrate substantial heterogeneity in recognition of different recombinant PDC-E2 fragments and differential recognition patterns against mutant constructs of the human PDC-E2 inner lipoyl domain (amino acid residues 91 to 227). In addition, five of the antigen-binding fragment clones (SP1, 3, 4, 8 and 12) demonstrate different staining patterns on biliary epithelial cells of patients with primary biliary cirrhosis but not control liver disease; some antigenbinding fragments specifically stained the apical region of biliary epithelium, a pattern distinct from that of typical mitochondrial staining. The response to the inner lipoyl domain is not, however, monospecific, and there is much more heterogeneity in fine specificity than could be accounted for by arbitrary reshuffling of variable immunoglobulin heavy and light chains into unnatural combinations. (HEPATOLOGY 1994;20:574-;583).
Effect of Chronic hCG Administration on Alzheimer’s-Related Cognition and Aβ Accumulation in PS1KI Mice
Authors: A. M. Barron, G. Verdile, K. Taddei, K. A. Bates, R. N. Martins
Journal: Endocrine Reviews (2010)

Age-associated changes in the reproductive hormones—the gonadal steroid hormones and the gonadotropins—have been identified as potential risk factors for Alzheimer’s disease (AD). However, levels of gonadotropins and estrogens are closely linked in vivo, and it has proven difficult to separate the effects of gonadotropins from the well-documented estrogenic effects on AD-related neuropathology in experimental models of menopause. To assess the effects of gonadotropins on cognition and AD biochemical markers independent of estrogenic effects, a potent analog of luteinizing hormone [human chorionic gonadotropin (hCG)] was administered to ovariectomized Presenilin1 knock in mice (PS1KI). Gonadotropin administration was found to induce hyperactivity and anxiety (Open Field Maze and Taste Neophobia Task) and working memory dysfunction, without altering reference memory (Morris Water Maze). Although gonadotropin administration modestly altered beta amyloid (Aβ40) levels, levels of the longer more toxic form (Aβ42) were unaffected. Furthermore, altered Aβ40 levels were not associated with observed behavioral and cognitive impairments. These findings provide proof, in principle, that the gonadotropin hormones play a role in the modulation of AD-related behavior, cognition, and neuropathology.
Journal of Immunology, Baltimore
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Precursor Cells in Mouse Islets Generate New β-Cells in Vivo during Aging and after Islet Injury
Authors: H. Liu, Y. Guz, M. H. Kedees, J. Winkler, G. Teitelman
Journal: Endocrine Reviews (2010)

ABSTRACT Whereas it is believed that the pancreatic duct contains endocrine precursors, the presence insulin progenitor cells residing in islets remain controversial. We tested whether pancreatic islets of adult mice contain precursor β-cells that initiate insulin synthesis during aging and after islet injury. We used bigenic mice in which the activation of an inducible form of cAMP response element recombinase by a one-time pulse of tamoxifen results in the permanent expression of a floxed human placental alkaline phosphatase (PLAP) gene in 30% of pancreatic β-cells. If islets contain PLAP− precursor cells that differentiate into β-cells (PLAP−IN+), a decrease in the percentage of PLAP+IN+ cells per total number of IN+ cells would occur. Conversely, if islets contain PLAP+IN− precursors that initiate synthesis of insulin, the percentage of PLAP+IN+ cells would increase. Confocal microscope analysis revealed that the percentage of PLAP+IN+ cells in islets increased from 30 to 45% at 6 months and to 60% at 12 months. The augmentation in the level of PLAP in islets with time was confirmed by real time-PCR. Our studies also demonstrate that the percentage of PLAP+IN+ cells in islets increased after islet injury and identified putative precursors in islets. We postulate that PLAP+IN− precursors differentiate into insulin-positive cells that participate in a slow renewal of the β-cell mass during aging and replenish β-cells eliminated by injury.
Hybrid words in medical terminology
Authors: J. H. Dirckx
Journal: JAMA (1977)

SEVERAL communications recently published in the medical literature have stirred up the embers of an ageold controversy about compound words that contain both Greek and Latin elements. Ganias<sup>1</sup>proposed the introduction of five new ophthalmologic terms of Greek origin to rectify certain bilingual coinages that he found "complicated and confusing." In a related editorial,<sup>2</sup>Blodi approved the effort to "keep the language unadulterated," ie, to avoid coupling Greek with Latin. Hussey<sup>3</sup>took up the question of hybrid terms and dealt with it in a reasonable and practical fashion. After contributing his own balanced views, he presented the results of a small poll of other editors' opinions: all agreed that opposition to Greek-Latin hybrids is, in general, both groundless and futile. My purpose is to place the question in historical perspective and to offer practical suggestions for its resolution. <h3>THE DEVELOPMENT OF TECHNICAL NOMENCLATURE</h3> A living language evolves
Two wrongs don't make a right. Managed care, mental health, and the marketplace
Authors: M. S. Jellinek
Journal: JAMA (1993)

PRIOR to 1980, mental health coverage was primarily based on fee-for-service reimbursement through indemnity plans. Outpatient benefits varied from minimal to generous; decisions concerning psychiatric hospitalization (and to a great extent length of stay) were based on the psychiatrist's clinical judgment and only somewhat constrained by the paucity of beds. During the past 15 years, the mental health delivery system has undergone a two-stage evolution.<sup>1</sup>The first stage was free-market competitive expansion. As a result, the use of inpatient services increased, especially the for-profit psychiatric hospitalization of adolescents. The second stage was managed care, dramatically decreasing the use of psychiatric hospitalization. The engine for both the first and second set of changes was not innovative treatment or outcome studies; on the contrary, it was profit that filled psychiatric beds in the 1980s, and it is profit that empties them in the 1990s. This profit is eroding the traditional covenant
Prediabetes' Research—A Means to Eventual Prevention of Diabetes
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 19488: Improved Success in Patency and Symptomatic Relief Using Optical Coherence Tomography Guided Superficial Femoral Artery Chronic Total Occlusion Intervention Compared With Standard Techniques
Authors: Perwaiz M Meraj, Rajkumar Doshi, Pavitra Vijayaraghavan, Daniel Helfgott
Journal: Circulation (2015)

Background: Superficial femoral artery (SFA) chronic total occlusion (CTO) peripheral vascular intervention (PVI) is a challenging procedure given the longer procedure times, larger amount of radiation dose, and lesser procedural success. The aim of this single center analysis is to determine if patency and symptom relief is improved using Optical Coherence Tomography (OCT) based Ocelot versus conventional guidewires in SFA CTO PVI. Methods: We retrospectively analyzed 213 patients with SFA CTO undergoing PVI with either traditional techniques or the Ocelot device. Outcomes measured were death, vascular complications, procedural success, Rutherford class improvement, and a composite endpoint of ABI improvement above 0.9, ultrasound duplex velocity less than 250 m/s and Rutherford improvement. Unadjusted and multivariate analyses were performed. Results: 36 cases of SFA CTO were performed with the Ocelot device, while 177 were performed with traditional guidewire techniques. Both improvement in Rutherford Class and the composite endpoint of success were significantly better with using the Ocelot device in the unadjusted analysis. They remained significant after performing multivariate analysis. Conclusion: The Ocelot device is a revolutionary device the successful and effective management of SFA CTO PVI. Symptomatic relief and patency are demonstrated here to be significantly improved when utilizing the Ocelot device. Further analysis of lesion length and calcium burden are needed to determine its optimal use for procedural and long term success.