tbuckley/cabot-search huggingface dataset:
The Plastic Corneal Implant
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Induction of Internucleosomal DNA Fragmentation by Carcinogenic Chromate: Relationship to DNA Damage, Genotoxicity, and Inhibition of Macromolecular Synthesis
Authors: Francis C. R. Manning, Lori J. Blankenship, John P. Wise, Jian Xu, Laura C. Bridgewater, Steven R. Patierno
Journal: Environmental Health Perspectives (1994)

Hexavalent chromium (Cr) compounds are respiratory carcinogens in humans and animals.Treatment of Chinese hamster ovary cells with 150 and 300 pM sodium chromate (Na2CrO4) for 2 hr decreased colony-forming efficiency by 46 and 92%, respectively.These treatments induced dose- dependent internucleosomal fragmentation of cellular DNA beyond 24 hr after chromate treatment.This fragmentation pattern is characteristic of apoptosis as a mechanism of cell death.These treatments also induced an immediate inhibition of macromolecular synthesis and delayed progression of cells through S-phase of the cell cycle.Cell growth (as evidenced by DNA synthesis) was inhibited for at least 4 days and transcription remained suppressed for at least 32 hr.Many of the cells that did progress to metaphase exhibited chromosome damage.Chromate caused the dose-dependent formation of DNA single-strand breaks and DNA-protein cross-links, but these were repaired 8 and 24 hr after removal of the treatment, respectively.In contrast, Cr-DNA adducts (up to 1/100 base-pairs) were extremely resistant to repair and were still detectable even 5 days after treatment.Compared with other regions of the genome, DNA-protein cross-links and Cr adducts were preferentially associated with the nuclear matrix DNA of treated cells, which was 4.5-fold enriched in actively transcribed genes.Chromium adducts, formed on DNA in vitro at a similar level to that detected in nuclear matrix DNA, arrested the progression of a DNA polymerase in a sequence-specific manner, possibly through the formation of DNA-DNA cross-links.Total RNA and mRNA synthesis and induction of expression of the inducible GRP78 gene were suppressed in a concentration-and time-dependent manner by chromate.The effects of chromate on GRP78 induction correlated most closely with the presence of DNA-protein cross-links but suppression of total RNA and mRNA synthesis correlated with the presence of DNA-Cr adducts in cells.These results suggest that the persistent Cr-DNA adducts may be responsible for the protracted cell cycle delay and transcriptional inhibi- tion caused by chromate.Escape from apoptosis may be one of the steps involved in chromate-induced carcinogenesis.-
Error in Article Title
Journal: JAMA Pediatrics (2018)

Blood Cell Counts to Identify Febrile Infants 60 Days or Younger With Invasive Bacterial Infections," 1 published online September 11, 2017, and printed in the November 2017 issue of JAMA Pediatrics, there was an error in the second paragraph of the Key Points.The numerical value for the absolute neutrophil count should be Ն10 000/μL.This article was corrected online.
EFFECT OF TONSILLECTOMY ON GENERAL HEALTH IN FIVE THOUSAND CHILDREN
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Society for Molecular Biology and Evolution Council and Business Meetings, 2003 Newport Beach, California, USA
Authors: Simon Easteal, G Golding, Jody Hey, Michael Clegg, John Avise, Marta Wayne, Elizabeth Raffaele, Cathy Ken- Nedy, Pete Hoffmann, Daniel Dykhuizen, Brandon Gaut, Cecilia Saccone, Marcy Uyenoyama, William Birky, Jeffrey Powell, Mark Batzer, Sudhir Kumar, Laura Katz, Kenneth Wolfe
Journal: Molecular Biology and Evolution (2003)
Prospects for prevention of and early intervention against HIV
Authors: D. P. Bolognesi
Journal: JAMA (1989)

THE IMMUNE response that develops subsequent to infection with human immunodeficiency virus (HIV) consists of both humoral and cellular elements that, when assessed in vitro, can inhibit virus infection and lyse virus-infected target cells. If such activities were operative in vivo, one would expect that they would suppress virus replication and virus-induced cytopathic effects. The antiviral immune response may thus represent one of the primary host defense mechanisms responsible for the protracted asymptomatic phase of the disease, which, in most patients, can last several years. An important question to be answered for development of vaccine strategies against HIV is whether this response might be an effective barrier to HIV infection de novo. If the immune response can indeed control the virus even for a limited period, then the issue would not be whether it is possible to mount a protective immune response against HIV, but whether it may be necessary
MEETINGS
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Deborah Doniach
Journal: BMJ (2004)

An immunologist who initiated our understanding of autoimmune diseases Deborah Doniach was part of a groundbreaking team that showed that Hashimoto's disease of the thyroid was caused by autoimmunity.Hitherto it was thought that antibodies in blood were specifically targeted against external agents, mainly bacteria and viruses.The discovery led to the wider concept of organ-specific autoimmunity, later found to be a major causal factor in other endocrine disorders.Doniach postulated that Addison's disease, thyrotoxicosis, myxoedema, pernicious anaemia, and hypoparathyroidism might have the same aetiology, as diabetes mellitus was common in all of them.The eldest of three daughters of a Ukrainian concert pianist and a bohemian Norwegian teacher of therapeutic dance, Doniach was charming and cultivated, and a talented musician.Her father, a passionate Zionist who had changed his name from Joseph Niswitzki to Arieh Abileah, eventually became professor of music at the Jerusalem Conservatory.Deborah was educated at the Lycée Molière in Paris and studied medicine at the Sorbonne, interrupting her studies in 1934 to marry Israel "Sonny" Doniach, whom she had first met in Palestine when she was 15; they spent 75 years together.Moving to London, she enrolled at the Royal Free Hospital Medical School.She spent three years as house physician, surgeon, and junior medical officer in the London County Council service, followed by four years as assistant lecturer in chemical pathology at the Middlesex Hospital.In 1951 she moved to the Royal Free, returning to the Middlesex as an endocrinologist two years later.She spent the rest of her career there, becoming one of the first immunopathologists and rising to the rank of professor in 1974.Doniach discovered that patients with thyroiditis-Hashimoto's disease-had raised
On the Pathology and Treatment of Ovarian Diseases
Authors: L. Tait
Journal: BMJ (1874)

Inactivation of antigen processing and presentation (APP) pathways is one of the major mechanisms for immune evasion in many cancer types including high-grade endometrial cancer (HGEC). Impairments in APP pathways may contribute to the low immunotherapy response rate among the patients. However, lack of pre-clinical models for HGEC poses a significant challenge in studying critical therapeutic aspects of the cancer such as cancer-immune cell interactions. To our knowledge, we have established the largest endometrial biobank comprising primary tissues, patient-derived organoids (PDO), and their matching immune cells from all existing endometrial cancer types, enabling us to establish the interaction between cancer and immune cells in vitro. Using a subset of our biobank, we performed RNA-seq on 68 PDOs and found that genes involved in APP pathways are downregulated in HGEC organoids compared to their matching normal pairs. We found that MHC-I and -II could be upregulated by IFNg and Tazemetostat, an EZH2 inhibitor. We further assessed the effects of enhanced MHC-I and -II expression mediated by the two molecules on cancer-immune cell interactions by setting up syngeneic organoid-immune cell co-cultures. We found that HGEC organoids that were pre-treated with IFNg or Tazemetostat displayed a greater immune cell co-localization and immune cell-mediated apoptosis during the co-culture period. Our proof-of-principle experiments demonstrate the utility of our co-culture system in studying the cancer-immune cell interactions in vitro. Our system could be used to test the efficacy of current therapeutics or to screen potential drugs which enhance immune responses against HGEC, which lacks effective treatment options. This research was supported by grants from The Mark Foundation for Cancer Research (20-028-EDV630), NCI CancerCenter Support&nbsp;Grant (5P30CA045508),and CSHL-northwell transitional research fund.
Boxing
Authors: James M. Corkum
Journal: JAMA (1985)

<h3>To the Editor.—</h3> Amid the barrage of disparaging and admonitory media coverage, I would like to offer another point of view concerning the sport of boxing. As a former world-ranked professional boxer and current medical student, I think that I have a unique vantage. There are many aspects of the fight game that the average spectator and, most assuredly, the avid critic cannot appreciate. Through rigorous training and diligent practice, individuality and a sense of self are nurtured. How better can one realize one's capabilities and limitations than through controlled, physical, one-on-one competition? Motivating him with the desire to win and the threat of defeat, the situation of the fight brings forth the finest in the athlete, psychologically as well as physically. The costs and rewards of hard work are quickly realized. Determination and self-discipline are unquestionably admirable qualities. Developed through necessity, they become a part of the fighter's person.
THE TRAVELING ADVERTISING DOCTOR TURNED DOWN.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Headache
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lymphoepithelial Structures and Autoimmune Disease
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Deferred consent. A new approach for resuscitation research on comatose patients
Authors: N. S. Abramson
Journal: JAMA (1986)

Methodological constraints inherent in the rapidly growing field of resuscitation research have created an apparent conflict with newly promulgated federal regulations, especially those concerning informed consent requirements. We propose that two new concepts be applied to resuscitation research to satisfy the current federal regulations governing biomedical research. The first of these concepts is "minimal differential risk," ie, in resuscitation medicine, the difference between the risk of an undesirable outcome when standard, commonly accepted therapy may be used and the risk of an undesirable outcome with experimental therapy is minimal. The second concept is "deferred consent," ie, obtaining consent to<i>continue</i>with an experimental therapy after administration of that therapy has already begun. We believe that the emergency exception to informed consent applies to resuscitation research. Recognition of the applicability of these concepts to resuscitation research should allow compliance with federal and state regulations that otherwise might inhibit or preclude such research endeavors. (<i>JAMA</i>1986;255:2466-2471)
Editorial Board
Authors: Daniel Cattran, P Coates, Andrew Davenport, Tilman Drueke, Paris Ckd, Associated Complications, Masaomi Nangaku, Jai Radhakrishnan, New York, Maria Rastaldi, W Reeves, San Antonio, Detlef Schlöndorff, Michael Ross, Qais Al-Awqati, York New, Christina Wyatt, Vic Hasselblad, Jacksonville Zhezhen, Joseph Kim, Yi-Ju Li, , Durham, Dorothea Nitsch, London Ramakrishnan, Anupam Agarwal, Hans Anders, Jonathan Barratt, Daniela Leicester, São Barreto, David Paulo, Tomas Basile, Francois Denver, Joseph Berthoux, Emmanuel Boston, São Burdmann, Giovambattista Paulo, Christos Napoli, Yi-Pu Paris, Erik Chen, Steven Christensen, New Coca, Terence York, London Cook, D Vivette, New Agati, Farhad York, John Danesh, Ian Chicago, Marc De Boer, Antwerp De Broe, Vikas Zurich, St Dharnidharka, Zheng Louis, Adriana Dong, Kai-Uwe Oviedo, Erlangen Eckardt, Eiam-Ong Somchai, Michael Emmett, Dallas Endre, Sydney Evan, Pieter Evenepoel, Sarah Leuven, Denver Faubel, Steven Faul, Danilo Mineola, Jürgen Homburg, Agnes Aachen, Alessia Nashville, Barry Miami, Winston-Salem Freedman, Isehara Masafumi Fukagawa, Vesna Garg, Rochester Garovic, Laguna Glassock, Glenda Niguel, David Gobe, New Goldfarb, Matthew York, Mark Griffin, Angeles Haas, John Haase, Cijiang He, Michelle Hladunewich, Thomas Hostetter, Chi-Yuan Cleveland, San Hsu, Tobias Francisco, Benjamin Huber, St Humphreys, Reiko Louis, Jula Tokyo, Dallas Inrig, Francisco Kirsten Johansen, Roberto Kamyar Kalantar-Zadeh, Iowa Kalil, Yashpal City, Chicago Kanwar, New Kaskel, Krzysztof York, York Kiryluk, Clayton Kitching, Matthias Kopp, Ann Kretzler, Christian Arbor, Christophe Bonn, Paris Legendre, Los Lemley, Adeera Angeles, Philip Levin, Hong Li, Christoph Kong, John Toronto, Rochester Lieske, Jiannong Little, Kathleen Liu, San Liu, Youhua Francisco, Zhi-Hong Liu, Nanjing Liu, Dallas Lu, Matthias Berlin, Johannes Mack, Peter Mann, Hamilton Margetts, Kunihiro Amiens, William Matsushita, Atlanta Mcclellan, Timothy Mehrotra, Palo Meyer, Jeffrey Alto, St Miner, William Louis, Houston Mitch, Jeremiah Moeller, St Morrissey, Rosa Louis, São Moysés, Rama Paulo, Peter Duarte, David Nelson, Clayton Nikolic-Paterson, Klaus Charlottesville, Juan Oliver, York Charles O'neill, Atlanta Panzer, Mark Perazella, New Haven, Janos Peti-Peterdi, Los Angeles, Laura Plantinga, Atlanta Pollak, Didier Boston, Ambra Charlottesville, Susan Pozzi, Chicago Quaggin, Jochen Reich, Giuseppe Reiser, Sharon Bergamo, Mariano Clayton, Mitchell Rodriguez, Robert Rosner, Simone Safirstein, New Sanna-Cherchi, Antonio York, Kai Santoro, New Schmidt-Ott, Kumar York, La Sharma, Edward Jolla, Katalin Siew, Philadelphia Susztak, C Sydney, Hong Tang, Ravi Kong, Joshua Boston, Jens Denver, Marcello Nashville, Frank Tonelli, Manjeri Van Der Sande, San Venkatachalam, Carsten Antonio, Joel Wagner, Ann Weinberg, Matthew Arbor, Donald Weir, Temple Wesson, Jack Westenfelder, Adam Wetzels, Myles Whaley-Connell, Keng-Thye Wolf, Kwan-Dun Woo, Taiwan Wu, Yusuke Suzuki, Tokyo Zeisberg
Journal: Kidney International (2016)
Nonoperative treatment of unilateral renal vein thrombosis in the newborn
Authors: A. B. Belman
Journal: JAMA (1970)

Acute renal vein thrombosis in the newborn has been considered a surgical emergency. More recently, survival without surgical intervention has been reported. Seven patients were treated without operation. There were six survivors with pyelographically demonstrated return of visualization on the affected side in four. One atrophic kidney resulted. Diagnosis of renal vein thrombosis is made when flank mass and hematuria are present in association with pyelographic nonvisualization and thrombocytopenia. It occurs most often in children of diabetic mothers and in the presence of diarrhea. Dialysis is recommended in the event of bilateral involvement, as return of renal function is likely.
GENEVA
Journal: JAMA (1926)

<h3>Dentistry in Switzerland</h3> The practice of dentistry in Geneva has at last been settled, thanks to the following case: A certain dentist of Swiss nationality possessed a French diploma of dentistry. He had obtained from the council of state of Geneva the permission to practice temporarily, although this permission was contrary to the law. Therefore, the syndicate of dentists of Geneva appealed to the federal court, which decided against the decree of the council of state, basing its decision on article 4 of the federal constitution, on "suppression of privileges and equality of citizens before the law." Then the dentist in question launched a popular vote to change the law in his favor. The change consisted in adding the paragraph: "Every Swiss or naturalized Swiss for ten years, having obtained the diploma of dentist in any foreign country which entails the right to practice in that country, can practice his