tbuckley/cabot-search huggingface dataset:
THE DISFIGUREMENTS OF SMALLPOX.
Journal: JAMA (1896)

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Prescription Notes.
Journal: JAMA (1926)

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DRUNKENNESS.
Journal: JAMA (1906)

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No Pretending Not to Know
Authors: Loren A. Rolak
Journal: JAMA (1989)

<h3>To the Editor.—</h3> Regarding the article "No Pretending Not to Know,"<sup>1</sup>we feel that Dr Brown, as a consultant, has made an error in judgment by revealing unfavorable diagnostic and prognostic information to a patient who directly asked him the results of an examination that he had just performed. He defends his revelation as justifiable because to do otherwise and "lie" would be improper, and "it was what any physician would have done." We would not have done so. Dr Brown obviously is aware of the traditional arguments against such revelations because he enumerates them by admitting that he is not the patient's primary physician, not familiar with all the details of her case, not knowledgeable of almost any of the events leading to his contact with her, and not aware of who, if anyone, will discuss the results and implications of this test with her. He feels that
OA 07.06 Innate Genetic Evolution of Lung Cancers and Spatial Heterogeneity: Analysis of Treatment-Naïve Lesions
Authors: K. Suda, J. Kim, I. Murakami, L. Rozeboom, C. Rivard, T. Mitsudomi, A. Tan, F.R. Hirsch
Journal: Journal of Thoracic Oncology (2017)
Economics of care
Journal: Hepatology (2013)

Background.Drug compounds have been shown to exert certain effects on pathophysiological mechanisms involving hepatobiliary transporters in toxic hepatitis (TH) leading to liver dysfunction.Localization and individualized substrate specificities have been proposed to be crucial in TH development.Aims.Evaluate the expression of MDR1, MRP2, MRP3 and BSEP and their association with drug type administered in liver biopsies of patients with TH.Methods.We analyzed data from 16 patients with clinical, biochemical and histopathological diagnosis of TH and 16 without TH (Non-TH).TH patients presented a multidrug-therapy pattern which includes principally immunosuppressive, analgesics and antibiotic drugs.Hepatobiliary transporter expression was analyzed by quantitative real-time PCR and immunohistochemistry. RUCAM score was used to associate a specific expression pattern for a particular drug.Results.Sixteen patients (7 women and 9 men) with a mean age of 43.6 years.mRNA expression was significantly lower in TH group than in Non-TH group in MRP2 (p< 0.03), MRP3 (p< 0.05) and BSEP (p< 0.0009).In protein expression MDR1 and MRP2 showed a 100% positivity expression in both groups; however in terms of intensity, MDR1 expression was higher in TH group (75%) than in Non-TH group (45%) (P<0.01),opposite to MRP2 expression which was lower In TH group (31%) than in Non-TH group (45%) (P<0.01).Regarding MRP3, TH group showed a 56% of positivity expression; meanwhile it was not detectable in Non-TH group.Finally, BSEP presented a lower positivity expression (50%) in comparison to Non-TH group (95%) (Figure).Conclusion.In TH patients there was a down-regulation in BSEP, an increased expression in MRP3 and apparently no change in MRP2 and MDR1 expression.One of the main pathophysiological mechanisms involves the modulation of hepatobiliary transporter expression by drugtype administered in TH.Further studies which precise and determine the molecular mechanism involved in the regulation of TH development and drug therapy in order to design therapeutic options that become applicable to improve the prognostic in these patients.
What has happened to the AAMC since the Coggeshall Report of 1965?
Authors: W. G. Anlyan
Journal: JAMA (1969)

There was a day when the part-time dean could steer his medical school. His responsibility involved the four years of undergraduate medical education. Once a year, he could adequately represent his medical school on the national scene at the annual meeting of the Association of American Medical Colleges (AAMC), which was founded in 1876. Today the dean finds himself at the helm of an academic medical center comprising a complex of undergraduate medical education programs; graduate PhD programs in the basic sciences; graduate medical education with interns, residents, and fellows equal in number to the number of medical students; continuing education for physicians in the region; a multimillion dollar research program (which in many instances is multidisciplinary and multidepartmental); one or more teaching hospitals which hover on the brink of financial insolvency; a fast-changing and expanding interest of federal and state government in health affairs; expanding needs of society in
Annales de Pediatrie, Paris
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Forms and Prevalence of Intersexuality and Effects of Environmental Contaminants on Sexuality in Cricket Frogs (Acris crepitans)
Authors: A. L. Reeder, G. L. Foley, D. K. Nichols, L. G. Hansen, B. Wikoff, S. Faeh, J. Eisold, M. B. Wheeler, R. Warner, J. E. Murphy, V. R. Beasley
Journal: Environmental Health Perspectives (1998)

Cricket frogs (Acris crepitans) from several different sites in Illinois were collected to assess the effects of environmental contamination on the prevalence of intersex gonads. Of 341 frogs collected in 1993, 1994, and 1995, 2.7% were intersex individuals. There was no statistically significant relationship between the chemical compounds detected and cricket frog intersexuality. However, there was an association approaching significance (p = 0.07) between the detection of atrazine and intersex individuals. A comparison of reference sites with sites that had point polychlorinated biphenyl (PCB) and polychlorinated dibenzofuran (PCDF) contamination revealed a significant relationship between sex-ratio reversal and contamination with PCBs and PCDFs. The sex ratio of juvenile frogs studied from three sites with PCB and PCDF point contamination favored males over females, which was the opposite of the sex ratio in control ponds (p = 0.0007). The statistically significant correlation between organochlorine contamination and sex-ratio reversal suggests PCBs and PCDFs can influence cricket frog sexual differentiation. The current study suggests that in cricket frogs, sex ratios and the prevalence of intersex gonads are altered by environmental contamination.
Vertebrobasilar injuries following cervical manipulation
Authors: K. P. Schellhas
Journal: JAMA (1980)

Four cases of brainstem stroke syndromes followed mechanical cervical manipulation; vascular injury was confirmed angiographically. A comprehensive review of the literature on vertebrobasilar injuries disclosed the various mechanisms of injury and pathogenesis of subsequent vascular complications following cervical manipulation. Emphasis is given to the potentially devastating neurological complications, particularly in view of the increasing utilization of chiropractic therapy. (<i>JAMA</i>244:1450-1453, 1980)
Heterogeneity of coronary heart disease risk factors in Indian, Pakistani, Bangladeshi, and European origin populations; cross sectional study: Table 6.
Journal: BMJ (1999)

Objective To compare coronary risk factors and disease prevalence among Indians, Pakistanis, and Bangladeshis, and in all South Asians (these three groups together) with Europeans.Design Cross sectional survey.Setting Newcastle upon Tyne.Participants 259 Indian, 305 Pakistani, 120 Bangladeshi, and 825 European men and women aged 25-74 years.Main outcome measures Social and economic circumstances, lifestyle, self reported symptoms and diseases, blood pressure, electrocardiogram, and anthropometric, haematological, and biochemical measurements.Results There were differences in social and economic circumstances, lifestyles, anthropometric measures and disease both between Indians, Pakistanis, and Bangladeshis and between all South Asians and Europeans.Bangladeshis and Pakistanis were the poorest groups.For most risk factors, the Bangladeshis (particularly men) fared the worst: smoking was most common (57%) in that group, and Bangladeshis had the highest concentrations of triglycerides (2.04 mmol/l) and fasting blood glucose (6.6 mmol/l) and the lowest concentration of high density lipoprotein cholesterol (0.97 mmol/l).Blood pressure, however, was lowest in Bangladeshis.Bangladeshis were the shortest (men 164 cm tall v 170 cm for Indians and 174 cm for Europeans).A higher proportion of Pakistani and Bangladeshi men had diabetes (22.4% and 26.6% respectively) than Indians (15.2%).Comparisons of all South Asians with Europeans hid some important differences, but South Asians were still disadvantaged in a wide range of risk factors.Findings in women were similar.Conclusion Risk of coronary heart disease is not uniform among South Asians, and there are important differences between Indians, Pakistanis, and Bangladeshis for many coronary risk factors.The belief that, except for insulin resistance, South Asians have lower levels of coronary risk factors than Europeans is incorrect, and may have arisen from combining ethnic subgroups and examining a narrow range of factors.
Hemoglobin electrophoresis
Authors: A. L. Louderback
Journal: JAMA (1967)

Electrophoretic separation of sickle-cell hemoglobins in 1949 introduced the concept of "molecular diseases." Since then, electrophoretic techniques have been perfected to separate, identify, and quantitate other normal and abnormal hemoglobins. The simple approach of electrophoresis makes it possible to diagnose the chief inherited disorders of hemoglobin, including sickle cell disease and the thalassemias. A molecule of human hemoglobin contains two pairs of polypeptide chains, each composed of more than 140 amino acid residues.<sup>1</sup>Fetal hemoglobin (F) consists of one pair of alpha and one pair of gamma chains, whereas adult hemoglobin (A) consists of pairs of alpha and beta chains. Hemoglobin A2, which is generally 2.5% of the hemoglobin in the adult, consists of alpha and delta chains. The alpha chains in the three varieties of normal hemoglobin are identical, but there are multiple differences in the amino acid sequences of the gamma, beta, and delta chains. The abnormalities
TENEMENTS.
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Advances in Electrocardiography
Authors: David H. Spodick
Journal: JAMA (1972)

The distinguished editors of this symposium, both of them household names in cardiology and cardiac physiology, have quite modestly eschewed direct participation, but they have very successfully recruited toplevel contributors to report the most significant basic and clinical advances in electrocardiography. It is difficult to select particularly outstanding contributions because of the uniform excellence of 26 well-chosen topics. These, grouped in broad areas, include general electrophysiology, conduction and rhythm disturbances, pre-excitation, cardiac hypertrophy, and infarction. Readers long familiar with the excellent studies of Horan and Flowers will not be disappointed by their three very helpful chapters: "Subtle Signs of Right Ventricular Enlargement," "Diagnostic Power of the Q-Wave" and "Mid- and Late Changes in the QRS Complex." The beautiful pathologico-clinical demonstrations of another distinguished team, James and Sherf, are nicely recapitulated in "P-Waves, Atrial Depolarization and Pacemaking Site" and "QRS Abnormalities in A-V Block." Elsewhere, Dr. James critically analyzes "hot" problems
DOMESTIC ABSTRACTS
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Relationship Between Early Diastolic Intraventricular Pressure Gradients, an Index of Elastic Recoil, and Improvements in Systolic and Diastolic Function
Authors: Michael S. Firstenberg, Nicholas G. Smedira, Neil L. Greenberg, David L. Prior, Patrick M. McCarthy, Mario J. Garcia, James D. Thomas
Journal: Circulation (2001)

Background Early diastolic intraventricular pressure gradients (IVPGs) have been proposed to relate to left ventricular (LV) elastic recoil and early ventricular “suction.” Animal studies have demonstrated relationships between IVPGs and systolic and diastolic indices during acute ischemia. However, data on the effects of improvements in LV function in humans and the relationship to IVPGs are lacking. Methods and Results Eight patients undergoing CABG and/or infarct exclusion surgery had a triple-sensor high-fidelity catheter placed across the mitral valve intraoperatively for simultaneous recording of left atrial (LA), basal LV, and apical LV pressures. Hemodynamic data obtained before bypass were compared with those with similar LA pressures and heart rates obtained after bypass. From each LV waveform, the time constant of LV relaxation (τ), +dP/dt max , and −dP/dt max were determined. Transesophageal echocardiography was used to determined end-diastolic (EDV) and end-systolic (ESV) volumes and ejection fractions (EF). At similar LA pressures and heart rates, IVPG increased after bypass (before bypass 1.64±0.79 mm Hg; after bypass 2.67±1.25 mm Hg; P &lt;0.01). Significant improvements were observed in ESV, as well as in apical and basal +dP/dt max , −dP/dt max , and τ (each P &lt;0.05). Overall, IVPGs correlated inversely with both ESV (IVPG=−0.027[ESV]+3.46, r =−0.64) and EDV (IVPG=−0.027[EDV]+4.30, r =−0.70). Improvements in IVPGs correlated with improvements in apical τ (Δτ =5.93[ΔIVPG]+4.76, r =0.91) and basal τ (Δτ =2.41[ΔIVPG]+5.13, r =−0.67). Relative changes in IVPGs correlated with changes in ESV (ΔESV=−0.97[%ΔIVPG]+23.34, r =−0.79), EDV (ΔEDV=−1.16[%ΔIVPG]+34.92, r =−0.84), and EF (ΔEF=0.38[%ΔIVPG]−8.39, r =0.85). Conclusions Improvements in LV function also increase IVPGs. These changes in IVPGs, suggestive of increases in LV suction and elastic recoil, correlate directly with improvements in LV relaxation and ESV.
HEIDENHAIN'S MICRO-TECHNIQUE.
Journal: JAMA (1892)

The course of science is from the simple to the complex; and then again, the extension of science depends upon the adoption of the simpler for more intricate and complex tools and methods. Histology and pathology advanced with the perfection of the microscope and then rested until the microtome gave them a new impulse. We hear no longer of microscopists, but of microtomists. The new impulse whichFlemmingandAltmanhave given microtomy depends upon more perfect and successful methods of fixation and staining. These methods have been too difficult and the materials too unstable to permit of their general use. It is, therefore, with satisfaction that we read in the<i>Medical News</i>, of November 19,Ohlmacher'srecommendation of the simpler method ofHeidenhain. This method is especially adapted to operators and physicians. The perfectly fresh tissue is cut in cubes no more than three-eighths of an inch square. It
Costs outweigh benefits of interferon in multiple sclerosis
Journal: BMJ (1999)

Alcohol lowers risk of heart disease through effect on lipids and haemostatic factors Results from observational studies provide strong evidence that people who drink moderate amounts of alcohol have a lower risk of developing coronary heart disease than those who abstain, but some have suggested that this association is spurious.Rimm et al (p 1523) conducted a meta-analysis of all experimental studies of alcohol intake to summarise the effects of alcohol on lipid and haemostatic factors and to explain the inverse association between alcohol intake and risk of coronary disease.With an alcohol intake of 30 g a day the authors project a 24.7% reduction in risk of coronary heart disease mediated through changes in concentrations of high density lipoprotein cholesterol, fibrinogen, and triglyceride.
American Journal of Medicine, New York
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal