tbuckley/cabot-search huggingface dataset:
Abstract 5733: Coronary Flow Reserve obtained by Transthoracic Echocardiography in Patients with Normal Coronary Arteries and Systolic Dysfunction, Normal Function and Coronary Artery Disease and Normal Function and Normal Coronary Arteries
Authors: Marta F Lima, Jeane Tsutsui, Ingrid Kowatsch, Altamiro Osorio, Wilson Mathias
Journal: Circulation (2008)

Coronary Flow Reserve (CFR) has already been shown a reliable marker of physiological significance of coronary artery disease (CAD) and has recently been demonstrated to be an independent predictor of events in patients with dilated cardiomyopathy (DCM). Objective: To determine CFR in patients (pts) with DCM without obstructive CAD and in pts with normal systolic function and with obstructive CAD. Methods: We prospectively studied 67 pts with normal systolic function (mean age 46+/− 12 years, 48% male, left ventricular ejection fraction (EF) &gt;65%) and 47 pts with DCM (mean age 59 +/− 11 years, 52% male, EF&lt;35%) who underwent coronary angiography within 6 months from stress echocardiography. Diastolic velocity flow in the mid left anterior descending coronary artery was obtained by transthoracic echocardiography with use of intravenous commercially available contrast agent (Definity, Bristol-Myers Squibb) at baseline and during adenosine infusion (140 mcg/Kg/min, for 6 minutes). CFR was determined as the ratio of peak diastolic velocity in hyperemic/baseline conditions. All pts underwent quantitative coronary angiography (QCA). Results: Feasibility for assessing CFR was 83% in pts with normal function and 91% in DCM. Among the 56 pts in the final study with normal function, 25 had significant CAD and 31 had normal coronary arteries. Peak diastolic velocities in each group are described in Table . CFR was 2.86+/−0.58 ín pts with normal function and no CAD, 1.57+/−0.32 in pts with normal function and CAD, and 2.14+/−0.49 in pts with DCM and no CAD (p&lt;0.01 between groups). Sensitivity, specificity and accuracy for detecting CAD in pts with normal function was 96%, 94% and 95%, respectively. However, when considering the group with DCM, sensitivity was 74%, specificity 66% and accuracy 69%. Conclusions: CFR can accurately detect pts with CAD when systolic function is normal. Pts with DCM have diminished CFR that lowers the predictive value of this parameter to detect CAD.
Evaluation of Pancreatic Biopsy
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Text-Book of Physiology.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Macrophage inflammatory protein–1α as a costimulatory signal for mast cell–mediated immediate hypersensitivity reactions
Authors: Dai Miyazaki, Takao Nakamura, Masako Toda, Kam-Wa Cheung-Chau, Ricardo M. Richardson, Santa Jeremy Ono
Journal: Journal of Clinical Investigation (2005)

Regulation of the immune response requires the cooperation of multiple signals in the activation of effector cells. For example, T cells require signals emanating from both the TCR for antigen (upon recognition of MHC/antigenic peptide) and receptors for costimulatory molecules (e.g., CD80 and CD60) for full activation. Here we show that IgE-mediated reactions in the conjunctiva also require multiple signals. Immediate hypersensitivity reactions in the conjunctiva were inhibited in mice deficient in macrophage inflammatory protein–1α (MIP-1α) despite normal numbers of tissue mast cells and no decrease in the levels of allergen-specific IgE. Treatment of sensitized animals with neutralizing antibodies with specificity for MIP-1α also inhibited hypersensitivity in the conjunctiva. In both cases (MIP-1α deficiency and antibody treatment), the degranulation of mast cells in situ was affected. In vitro sensitization assays showed that MIP-1α is indeed required for optimal mast cell degranulation, along with cross-linking of the high-affinity IgE receptor, FcεRI. The data indicate that MIP-1α constitutes an important second signal for mast cell degranulation in the conjunctiva in vivo and consequently for acute-phase disease. Antagonizing the interaction of MIP-1α with its receptor CC chemokine receptor 1 (CCR1) or signal transduction from CCR1 may therefore prove to be effective as an antiinflammatory therapy on the ocular surface.
Angiogenic Cytokines Are Increased in the Serum of Patients with Waldenastrom’s Macroglobulinemia (WM): Correlations with Clinical Data.
Authors: Athanasios Anagnostopoulos, Evangelos Terpos, Konstantinos Zervas, Efstathios Kastritis, Vangelis Eleftherakis-Papaiakovou, Irini Katodritou, Konstantinos Tsionos, Meletios A. Dimopoulos
Journal: Blood (2006)
Succinylcholine and trauma
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Peer Review Revamp
Journal: JAMA (2008)

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Diabetes Care at Diabetes Camps
Journal: Diabetes Care (2005)

opened the doors of the first diabetes camp in Michigan in 1925, the concept of specialized residential and day camps for children with diabetes has become widespread throughout the U.S. and many other parts of the world.It is estimated that worldwide camps serve 15,000 -20,000 campers with diabetes each summer (1).The mission of camps specialized for children and youth with diabetes is to allow for a camping experience in a safe environment.An equally important goal is to enable children with diabetes to meet and share their experiences with one another while they learn to be more personally responsible for their disease.For this to occur, a skilled medical and camping staff must be available to ensure optimal safety and an integrated camping/educational experience. • • • •
Riots and health.
Journal: BMJ (1971)

the Institute of Experimental Psychology at Oxford, are investigating the speed with which a person responds to a visual stimulus in relation to whether a previous stimulus was the same or different.They showed that, as might be expected, the second response was faster than the first if the two stimuli were similar in characters that had to be watched for.But they also showed that other characters not watched for quickened the response even more.Thus the first response seems to depend on a perception of the whole displayed object rather than individual features of it.Since much the greater part of the earth's surface is covered with water, it is only right that we should be deeply concerned about its denizens, and two exhibits were on this theme.The Government's Fisheries Radiobiological Laboratory at Lowestoft in Suffolk controls the main dis- charges of radioactive waste into lakes, rivers, and seas, giv- ing advice as well as monitoring the disposal of this most dangerous of man's effluvia.Among its investigations is one into the chronic effects of gamma-radiation on fish.Government laboratories at Burnham on Crouch in Essex and at Pitlochry in Perthshire also had a joint demonstration of their work on the monitoring of pesticides in fish.These two exhibits are symptomatic of a slight change in emphasis on the direction of scientific research.Though it may be carried out primarily to satisfy man's curiosity, the justification is commonly advanced that research is for his benefit.Now the question is being asked whether it is also for the benefit of other living organisms for the destruction of species and their habitats in the last hundred years is nothing less than alarming.
Conference of State Medical Examining and Licensing Boards.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Eine Methode zur Messung von Röntgen-, Radium- und Ultrastrahlung nebst einige Untersuchungen über die Anwendbarkeit derselben in der Physik und der Medizin: Mit einem Anhang Enthaltend einige Formeln und Tabellen für die Berechnung der Intensitätsverteilung bei γ-Strahlungsquellen
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mechanisms of the Biological Effects of PCBs, Polychlorinated Dibenzo-p-Dioxins and Polychlorinated Dibenzofurans in Experimental Animals
Authors: Robert A. Neal
Journal: Environmental Health Perspectives (1985)

Polychlorinated biphenyls, certain polychlorinated dibenzo-p-dioxins and certain polychlorinated dibenzofurans cause a variety of biological effects in experimental animals. The mechanism of the induction of certain enzymes is perhaps best understood. That is, there is binding of certain chlorinated biphenyls, dibenzo-p-dioxins and dibenzofurans to a receptor, translocation of the compound-receptor complex into the nucleus followed by an increased activity of a number of enzymes in the cell. Although the concentration of this receptor in various tissues of some mouse strains correlates well with the intensity of some of the biological effects observed in the mouse strains exposed to these compounds, this correlation apparently does not extend across various species. The current evidence suggests that the acute toxic effects of TCDD in various species is in some way associated with binding of TCDD to the receptor. However, biological effects of TCDD in addition to those resulting from binding to the receptor may be required to produce acute toxicity and, perhaps, other effects. The acute toxic effects of TCDD are probably caused by the parent compound rather than metabolites; however, this conclusion must be viewed as tentative. Also, it cannot be excluded at this time that biological effects other than acute toxicity may be caused by metabolites of TCDD. Finally, the acute toxic effects of TCDD appear not to be related, at least not directly, to the rate of metabolism of TCDD in experimental animals nor to the half-life of excretion.
How the UK drug regulator became the herbalists’ marketer
Journal: BMJ (2014)

the herbalists' marketerIn this No Holds Barred column by Margaret McCartney, she suggested in the first paragraph that the Medicines and Healthcare Products Regulatory Agency (MHRA) had approved devil's claw, arnica flower, palmetto fruit, and feverfew for efficacy (BMJ 2014;348:g3194, doi:10.1136/bmj.g3194).To clarify, the MHRA has granted these herbs "traditional herbal registration," which since 2005 has enabled endorsement without any evidence of efficaciousness from clinical trials, but the MHRA says that long term uses "indicate that efficacy is at least plausible.
Questions cliniques d'actualité. 4e série
Journal: JAMA (1935)

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Abstracts
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Social determinants of medical knowledge
Authors: R. Dubos
Journal: JAMA (1965)

Exactly 100 years ago, in the fall of 1865, Claude Bernard published his<i>Introduction to the Study of Experimental Medicine</i>, now regarded as one of the medical classics. Despite its austere language, the<i>Introduction</i>immediately achieved popularity with the educated public. The intellectual atmosphere was favorable for Claude Bernard's thesis because of the general awareness that the time had come to convert medicine from an empirical art into a scientific discipline. Claude Bernard would probably regard the event we are celebrating as the most suitable form of commemoration for the centenary of his book. However, it is for another reason that I have mentioned him. My purpose is to illustrate that social forces exert a profound influence on the success of scientific philosophies and medical institutions. Medicine became scientific through anatomical, physiological, and biochemical studies. Yet, the first large research institutes were not organized around these sciences; they were devoted
Examination of Sources of Public Water-Supplies.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
From the National Institutes of Health
Authors: William Raub
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal