tbuckley/cabot-search huggingface dataset:
Dietary Vitamin E Intake and Risk of Coronary Heart Disease in a Representative Sample of US Adults: NHANES I Epidemiologic Follow-up Study
Authors: Lydia A Bazzano, Jiang He, Lorraine G Ogden, Suma Vupputuri, Catherine Loria, Leann Myers, Paul K Whelton
Journal: Circulation (2001)

P78 Epidemiologic studies suggest that dietary vitamin E intake is inversely related to the risk of coronary heart disease (CHD). We examined the relationship between dietary intake of vitamin E and incidence of and mortality from CHD and cardiovascular disease (CVD) in 9,766 men and women who participated in the NHANES I Epidemiologic Follow-up Study and were free of CVD at their baseline examination. A 24-hour dietary recall was conducted at the baseline examination and nutrient intakes were recalculated using ESHA Food Processor software. Other important risk factors for CVD including age, sex, race, serum cholesterol, blood pressure, body mass index, history of diabetes, education, physical activity, cigarette smoking, and alcohol consumption were also measured at baseline. Those risk factors and dietary intake of saturated fat and total energy were used for adjustment in multivariate analyses. Incidence and mortality data for CHD and CVD were obtained from medical records and death certificates. Cox proportional hazard models were used to examine the relationship between dietary vitamin E intake and the incidence of and mortality from CHD and CVD. Over an average of 19 years of follow-up, 1,845 incident cases of CHD (669 fatal) and 3,760 incident cases of CVD (1,197 fatal) were documented. The adjusted relative risk (RR) was 0.89 (95% confidence interval [CI], 0.77-1.02, p=0.03 for trend) for incident CHD events, 0.69 (95% CI: 0.55−.86, p=0.001 for trend) for fatal CHD events, and 0.85 (95% CI: 0.70-1.02, p=0.03 for trend) for fatal CVD events among those in the highest quartile of dietary vitamin E intake (median, 17.5 mg/d) compared with those in the lowest quartile (median, 3.0 mg/d). These findings support the hypothesis that increasing vitamin E intake may be an important element of dietary approaches to reducing the incidence of and mortality from CHD in the US population.
Aminopyrine in Hodgkin's Disease
Authors: George X. Trimble
Journal: JAMA (1963)

<h3>To the Editor:</h3> —To any undiscerning Dr. Homer, the clinical note by Dr. Paul Spear, "The Use of Aminopyrine to Control Fever in Hodgkin's Disease" (<i>JAMA</i><b>180:970</b>[June 16] 1962) might appear to be the therapeutic plum in a somewhat prolegomenous pie. However, before Dr. Horner swallows this tidbit, I would like to season it with a dash of ipecac. Although, in his note, Dr. Spear refers to the toxic hazards associated with the use of aminopyrine, he, nevertheless, cites "a firm position" of the AMA Council on Pharmacy and Chemistry favoring the use of the drug, "where it was indicated and under medical supervision." Unfortunately, it may not be obvious that the imputed "firm position" may by now be somewhat tenuous, if only because its vintage dates back to 1934. I would like to direct Dr. Spear's attention to a letter written by Dr. Maxwell Wintrobe (<i>JAMA</i><b>178</b>:1050
Giving Pediatric Immunizations the Priority They Deserve
Authors: Joanne M. Hatem
Journal: JAMA (1993)

<h3>To the Editor.</h3> —Readers ofTHE JOURNALmay be interested in the development of the "Standards for Pediatric Immunization Practices" as announced by President Bush on May 11, 1992, and published April 14, 1993.<sup>1</sup> The National Vaccine Advisory Committee, composed of national and state public health officials, academicians, and consumers, approved similar recommendations in late April 1992 (these are unpublished). The Immunization Practices Advisory Committee of the Centers for Disease Control and Prevention (CDC) reviewed and approved the recommendations after formal adoption by the US Public Health Service. These points might be insignificant except for two factors. Nineteen standards were approved by the National Vaccine Advisory Committee, but only 18 appeared 2 weeks later when signed by the President. The eliminated standard read as follows: "Providers obtain permission to vaccinate a child from a parent, legal guardian, or an adult knowledgeable about the child's medical history and responsible for
Fetal hemoglobin expression in the compound heterozygous state for −117 (G→A) Aγ HPFH and IVSII‐745 (C→G) β+ thalassemia: A case study
Authors: George V.Z. Dedoussis, Klio Sinopoulou, Marilena Gyparaki, Aphroditi Loutradis
Journal: American Journal of Hematology (1999)

We studied a family in which two inherited defects of the non-α-globin cluster segregate: Greek hereditary persistence of fetal hemoglobin (HPFH) and β-thalassemia. The compound heterozygote is a healthy man with 43% HbF, Gγ/Aγ ratio (27:73) differing from that of 10 simple heterozygotes for the Greek HPFH (92:8), normal levels of total Hb (13.3 g/dl), and reduced HbA2 levels comparing with the levels of β-thal heterozygotes for the same mutation. Molecular analysis of the β-globin genotype revealed the presence of the IVSII-745 (C→G) β+ RNA splice mutation in trans with the −117 G→A Greek HPFH. The β+ mutation was linked to haplotype VII and the Greek HPFH was associated with haplotype Ia. The father of the compound heterozygote carries the Greek HPFH in trans with the −158 C→T on the Gγ promoter, which is linked with haplotype IV. He presented 13.5% HbF with a Gγ/Aγ ratio 75:25. His daughter was a compound heterozygote for the IVSII-745 mutation in trans with the −158 C→T, while her HbF levels were 3.7% with a Gγ/Aγ ratio 31:69. Am. J. Hematol. 61:139–143, 1999. © 1999 Wiley-Liss, Inc.
The Public Service.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Brain metastases in patients with urothelial carcinoma.
Authors: Helen Jane Boyle, Emilie Lavergne, Jean Pierre Droz, Nathalie Bonnin, Aude Flechon
Journal: Journal of Clinical Oncology (2013)

282 Background: Muscle invasive urothelial cancers are infrequent. Patients (pts) with metastatic disease have poor prognosis. Brain metastases (BM) are rare. The aim of this retrospective study is to analyse the characteristics, the treatment and the evolution of patients with BM treated in a single centre. Methods: Thirty pts with BM were identified among the 1591 pts with urothelial carcinoma seen at the Centre Léon Bérard, between 1994 and 2011. The study population was described, overall survival (OS) from diagnosis of BM was estimated by Kaplan-Meier method and prognostic factors were explored using a Cox model. Results: Twenty seven pts in our series were male. Median age at initial diagnosis was 60 years (range: 33.9-78.9 years). Twenty two pts had primary bladder tumours and 8 upper urinary tract tumours. Twenty four pts underwent surgery for their primary lesion, 2 received chemoradiotherapy and 4 did not receive any radical local treatment. Six pts had metastatic disease at initial presentation: 3 were operated on. Median delay between initial diagnosis and BM was 16.6 months (range: 0-56.4 months), 3 patients had BM at initial presentation. Median time between first metastases and BM was 10 months (range=0-52 months). Eleven patients developed BM as one of the first sites of metastases. BM were symptomatic in 28 pts: specific neurological symptoms (n=25), headaches (n=6), epilepsy (n=2). For the 2 other pts, they were discovered on a systematic brain MRI. Eighteen pts had cerebral metastases only, 5 pts had cerebellar metastases only, 6 had both; the last patient had cerebral, cerebellar and meningeal involvement. Half of the pts had only 1 brain lesion. Five pts were operated on: 4 received postoperative radiotherapy; 19 patients were given radiotherapy alone and 6 did not get any local therapy. In this series, median OS from diagnosis of BM was 3.4 months (IC95% [2.2-10.3]). Only the administration of chemotherapy after the diagnosis of BM was significantly associated with OS; probably because only fit enough patients were offered treatment. Conclusions: Prognosis of patients with urothelial carcinoma and BM is poor; however some patients have long survivals. Treatment is not codified as there is little data in the literature.
Gulstonian Lectures on the Physiological Actions and Therapeutical Uses of Conium, Belladonna, and Hyoscyamus, Alone and in Combination with Opium
Authors: J. Harley
Journal: BMJ (1868)

On tlie Physiological Action and Therapeuttical Use of Henbane, alone and in Combination wit/i Opiunm; and on the Combined Operation ofBelladonina and Opium.HYOSCYAMUS, or its active principle, when given in small doses, and such as are insufficient to produce positive dryness of the mouth, rapidly subdues ordinary excitement of the pulse, and reduces it, within an hour or two, to its slowest rate; that is to say, to that condition in which it may occasionally be found after a long period of complete rest of mind and body.For example, the pulse of a man ordinarily engaged shall be 8o.After a small dose of hyoscyamus (one-fortieth of a grain of sul- phate of hyoscyamia, or four drachms of tincture of henbane), it will gradually fall to 6o or 5o.In another person, whose pulse may be 72, we shall at the end of the same time find it steadily beating about 45.Schroff states that the three-hundred-and-thirty-third of a grain of
LONDON
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ERRATUM: Complications of Fiberoptic Gastrointestinal Endoscopy - Five Years' Experience in a Central Hospital
Authors: O. Reiertsen, J. Skjøtø, C. D. Jacobsen, A. R. Rosseland
Journal: Endoscopy (1987)

Correction to: Complications of Fiberoptic Gastrointestinal Endoscopy - Five Years' Experience in a Central HospitalEndoscopy 1987; 19(01): 1-6DOI: 10.1055/s-2007-1013011
Modern Aspects of Gastro-Enterology.
Authors: Arthur Massey, H Lewis
Journal: Annals of Internal Medicine (1933)

This is a very interesting book, especially for the scientist, in which Clark sets forth the fallacies incurred in applying mathematical reasoning to pharmacological processes.He points out what type of reasoning is justified, and its limits.While valuable to the scientist, it would be of little value to the ordinary practitioner.Epidemiology.in Relation to Air Travel.
<i>A Clinical Manual: A Guide to the Practical Examination of the Excretions, Secretions, and the Blood; for the Use of Physicians and Students.</i>By Andrew MacFarlane, A. B., M. D., Instructor in Neurology and Diseases of the Chest, in the Albany Medical College; Physician to St. Peter's Hospital for Incurables. G. P. Putnam's Sons, 1894
Authors: J. M. M.
Journal: American Journal of Psychiatry (1894)
OSTEOPATHIC LEGISLATION.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Medical and Orthopaedic Management of Chronic Arthritis
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Normal and Abnormal Biology of the Beta-Amyloid Precursor Protein
Authors: D. Selkoe
Journal: Annual Review of Neuroscience (1994)

The brain's default mode network consists of discrete, bilateral and symmetrical cortical areas, in the medial and lateral parietal, medial prefrontal, and medial and lateral temporal cortices of the human, nonhuman primate, cat, and rodent brains. Its ...Read More
Intraperitoneal therapy in ovarian cancer: time's up.
Authors: R F Ozols
Journal: Journal of Clinical Oncology (1991)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1991.9.2.197 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 1988567 Intraperitoneal therapy in ovarian cancer: time's up. R F OzolsxR F OzolsSearch for articles by this author https://doi.org/10.1200/JCO.1991.9.2.197 First Page PDF © 1991 by American Society of Clinical Oncology
New MRI techniques allow noninvasive peek inside the thinking human brain
Authors: A. A. Skolnick
Journal: JAMA (1992)

NEW MAGNETIC RESONANCE imaging (MRI) techniques may allow researchers and clinicians to noninvasively make images of the thinking human brain. MRI already has been established as a high-resolution in vivo method for studying the anatomy of the human brain and other organs. However, recently developed high-speed MRI techniques that measure changes in blood volume, flow, and oxygenation are now being used to produce the first functional MRI maps of human brain activity. Until now, functional maps of the human brain have been made using the radionuclide imaging techniques, positron emission tomography (PET) and single photon computer tomography (SPECT). Still, these techniques suffer from limited spatial and temporal resolution and they require patients to be injected with radioactive compounds, says John W. Belliveau, PhD, director of Cognitive neuroimaging at Massachusetts General Hospital, Charlestown, and Harvard Medical School, Boston. Speaking recently at a conference in San Francisco, Calif, Belliveau—who with Kenneth K.
Diseases of the Thyroid Gland.
Journal: JAMA (1929)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Assessing Discrimination Loss in Children
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Thiazolidinediones
Authors: Hannele Yki-Järvinen
Journal: New England Journal of Medicine (2004)

Despite a large need for new hypoglycemic therapies, given the epidemic of type 2 diabetes, very few agents have been introduced during the past 20 years. The thiazolidinediones represent a potentially important new group of drugs with a mechanism of action differing from and perhaps complementary to that of existing therapies. This article discusses present data on mechanisms, indications, and limitations of thiazolidinedione therapy.
EXCHANGING PROGRAMS. A HINT TO SECRETARIES.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Embryonic Treatment with Xenobiotics Disrupts Steroid Hormone Profiles in Hatchling Red-Eared Slider Turtles (Trachemys scripta elegans)
Authors: Emily Willingham, Turk Rhen, Jon T. Sakata, David Crews
Journal: Environmental Health Perspectives (2000)

Many compounds in the environment capable of acting as endocrine disruptors have been assayed for their developmental effects on morphogenesis; however, few studies have addressed how such xenobiotics affect physiology. In the current study we examine the effects of three endocrine-disrupting compounds, chlordane, trans-nonachlor, and the polychlorinated biphenyl (PCB) mixture Aroclor 1242, on the steroid hormone concentrations of red-eared slider turtle (Trachemys scripta elegans) hatchlings treated in ovo. Basal steroid concentrations and steroid concentrations in response to follicle-stimulating hormone were examined in both male and female turtles treated with each of the three compounds. Treated male turtles exposed to Aroclor 1242 or chlordane exhibited significantly lower testosterone concentrations than controls, whereas chlordane-treated females had significantly lower progesterone, testosterone, and 5[alpha]-dihydrotestosterone concentrations relative to controls. The effects of these endocrine disruptors extend beyond embryonic development, altering sex-steroid physiology in exposed animals.