tbuckley/cabot-search huggingface dataset:
Hepatitis C virus infection in kidney transplant recipients
Authors: J Lau
Journal: Hepatology (1993)

To determine the prevalence and significance of hepatitis C virus infection in kidney transplant recipients, paired serum samples collected from 100 renal allograft recipients on admission for kidney transplantation and 1 yr after transplantation were tested for antibody to hepatitis C virus with second-generation enzyme immunoassay and recombinant immunoblot assay and for hepatitis C virus RNA with reverse transcription–polymerase chain reaction. Before kidney transplantation, hepatitis C virus antibody was detected with second-generation enzyme immunoassay in 18 patients (12 second-generation recombinant immunoblot assay–positive, 6 second-generation recombinant immunoblot assay–indeterminate). Nine of 12 second-generation recombinant immunoblot assay–positive and 2 of 6 second-generation recombinant immunoblot assay–indeterminate samples were hepatitis C virus RNA positive. In addition, 7 of 82 patients who had no detectable antibody on second-generation enzyme immunoassay or second-generation recombinant immunoblot assay were hepatitis C virus RNA positive. After kidney transplantation, hepatitis C virus antibody was detected in 19 patients (12 second-generation recombinant immunoblot assay–positive, 7 second-generation recombinant immunoblot assay–indeterminate, 14 seropositive for hepatitis C virus antibody). Eleven of 12 patients with second-generation recombinant immunoblot assay–positive results and 4 of 7 with second-generation recombinant immunoblot assay–indeterminate results were positive for hepatitis C virus RNA. Hepatitis C virus RNA was present in 28 patients 1 yr after kidney transplantation. Six patients appeared to have acquired active hepatitis C virus infection 1 yr after kidney transplantation (seroconverted to hepatitis C virus RNA positivity). We found no correlation between the presence of hepatitis C virus markers in the pretransplant and posttransplant sera and clinical/biochemical parameters or clinical outcome. Hepatitis C virus infection was clinically silent in most patients. Semiquantitation of serum hepatitis C virus RNA in 25 patients with hepatitis C virus infection showed that the hepatitis C virus RNA titer remained the same (n = 12) or increased at least 10-fold (n = 12), and only 1 patient had a decrease in serum hepatitis C virus RNA level. These data suggest that (a) the prevalence of hepatitis C virus infection is high in kidney transplant recipients, (b) active hepatitis C virus replication may be present in the absence of hepatitis C virus antibody, (c) many of these patients who are second-generation enzyme immunoassay–positive but second-generation recombinant immunoblot assay–indeterminate are hepatitis C virus RNA positive, (d) hepatitis C virus infection is usually clinically silent during the initial follow-up period and (e) antirejection immunosuppression may enhance hepatitis C virus replication. (HEPATOLOGY 1993;18:1027-1031).
PRE-COLUMBIAN LEPROSY.
Authors: ALBERT S. ASHMEAD
Journal: JAMA (1895)

Mr. Saville tells me that in the pottery of ancient Mexico there are symbolic pictures of death; human faces with blinded eyes. It is at least his opinion that this extinction of the eyes means death; for the god of death of these peoples is always represented with a stick puncturing the eyes. But nothing that can be considered as disease representations has ever been found there. In Chiapas, Mexico, he says images have been recently found showing clubbed feet, arms in cramped positions, etc. This find is believed by archæologists to be exceedingly valuable, but it has not been, as yet, much reported upon. If leprosy existed in America in pre-Columbian times, and if these deformations on<i>huacos</i>pottery are intended to represent lepers, the same idea must have been conceived previously in Japan, or Eastern Asia in general, from whence the disease itself would be likely to have
Chronic Littritis
Authors: R. C. Webster
Journal: BMJ (1938)

Diseases Officer, Salford Chronic inflammation of the glands of Littre is one of the common sequelae of acute gonorrhoea.It is of considerable importance not only to the individual affected but also to the community, since it may cause the infective state to persist or may provoke a non-specific leucorrhoea in the patient's sexual partner.It is largely, if not-indeed entirely, due to improper treatment and is therefore preventable. Signs and SymptomsUrethral discharge, which is commonly slight in amount but may be profuse for longer or shorter periods, especially in neurotic patients, is usually most marked in the morning before micturating ; its appearance is often intermittent.Microscopical examination shows tangled tlhreads of mucus, epithelial cells, a few pus cells, and some bacteria; the urinary threads show similar appearances.Pus cells of polymorphonuclear type are not numerous, but may be more abundant during exacerbations.The bacteria are scanty as a rule ; various types of cocci are seen, a few bacilli, and occasionally some coarsely spiral organisms;
Monitoring Potential Neurotoxic Effects of Hazardous Waste Disposal
Authors: Herbert H. Schaumburg, Peter S. Spencer, Joseph C. Arezzo
Journal: Environmental Health Perspectives (1983)

This report reviews neurotoxicological principles relevant to situations of hazardous waste disposal. Some of the diagnostic techniques currently used for field assessment of nervous system dysfunction are critically evaluated. These include nerve conduction velocity, evoked potentials, neuropsychological testing and use of the Optacon.
Predominance of early endometrial cancers after long-term estrogen use
Authors: B. S. Hulka
Journal: JAMA (1980)

Clinical stage and pathological characteristics of endometrial cancer cases were related to several aspects of estrogen prescribing. In comparing 256 cases with 321 community control subjects, estrogen use of less than 3 1/2 years' duration did not increase the risk of endometrial cancer for any stage, grade, histological type, or extent of invasion. With long-term estrogen use (3 1/2 years or more), relative risks were significantly increased (5.2 to 7.6) for the early cancers—those clinically stage IA, histologically grade 1, and invading the endometrium only. These increases were seen with both high-dose (&gt;0.625 mg) and low-dose (≤0.625 mg) preparations. Risks were only minimally increased for the more advanced cancers. However, long-duration estrogen use did produce an increased risk of advanced cancer when administration was continuous rather than cyclic. (<i>JAMA</i>244:2419-2422, 1980)
Coronary Collaterals
Authors: MARSHALL FRANKLIN
Journal: Annals of Internal Medicine (1971)

Letters and Comments1 January 1971Coronary CollateralsMARSHALL FRANKLIN, M.D.MARSHALL FRANKLIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-74-1-147_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I am writing you concerning the article in your August 1970 issue entitled "Coronary Atherosclerosis, Coronary Collaterals, and Their Relation to Cardiac Function" by Drs. Richard H. Helfant, Harvey G. Kemp, and Richard Gorlin. It is my opinion that their article, as written, was well studied and well performed; however, I do feel certain additive "notations" should be made.1. Appropriate Timing of Collateralization: In order for collaterals to protect myocardial integrity, they must form before the vessel that receives them (recipient vessel) totally occludes.2.Adequacy of Collateralization:If a collateral vessel is only partially formed... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: 17 Old King's Hwy. S Darien, Conn. 06820 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 January 1971Volume 74, Issue 1Page: 147-147KeywordsStable coronary artery disease Issue Published: 1 January 1971 PDF downloadLoading ...
Intestinal Absorption — Aspects of Structure, Function and Disease of the Small-Intestine Mucosa
Authors: Leonard Laster, Franz J. Ingelfinger
Journal: New England Journal of Medicine (1961)

The Absorptive Process — Sugars, Lipids, Amino Acids and Vitamin B12 To study absorption, two different approaches have been used. In vivo methods, such as measuring the disappearance of a test substance from the gut, its appearance in body fluids or its fecal output, tend to yield over-all results determined by a number of metabolic processes of which absorption is only one. If excised intestinal tissue is studied in vitro as a whole segment, discrete absorptive activities may be delineated, and if it is studied as a homogenate, biochemical pathways may be analyzed, but the unnatural experimental conditions must . . .
γ-Cleavage-Independent Functions of Presenilin, Nicastrin, and Aph-1 Regulate Cell-Junction Organization and Prevent Tau Toxicity In Vivo
Authors: Laura E. Doglio, Ritu Kanwar, George R. Jackson, Mar Perez, Jesús Avila, Colin Dingwall, Carlos G. Dotti, Mark E. Fortini, Fabián Feiguin
Journal: Neuron (2007)
COLOR DESCRIPTION
Authors: Francesco Ronchese
Journal: JAMA (1960)

<h3>To the Editor:—</h3> In science, art, and industry, the descriptive terms such as very pale, very light, brilliant, light, moderate, and medium suggested in the letter by Dr. Appel inThe Journal, April 23, page 1971, may be adequate and acceptable, but the concern of a teacher or of a writer is to describe color to students, as well as to the conference of the experts, in a readily understandable way. Scientifically, it is appropriate to use the terms very pale, very light, brilliant, very brilliant, moderately brilliant, and dozens of varieties of the kind because eventually the scientist will refer to his Munsell Book of Colors or the ISSCC-NBS Method of Designating Colors. If one is to stick unequivocally to science, one should not use the terms carbon-dioxide snow, orange or olive color, butterfly rash, rusty sputum, ivory white, or map-of-Maine and map-of-California hyperpigmentation because the student may come
Limit Lifted
Authors: Mike Mitka
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hantavirus Pulmonary Syndrome—United States, 1995 and 1996
Journal: JAMA (1996)

Sporadic cases of hantavirus pulmonary syndrome (HPS), a severe cardiopulmonary illness first identified in 1993, continue to be recognized in the United States (1,2). This report describes the investigation of two cases of Sin Nombre virus (SNV)-associated HPS involving feedlot workers in a single household during May-June 1995, and summarizes national reporting for HPS through March 21, 1996. The findings of this investigation and of other investigations suggest that, although domestic and occupational exposures to rodents have rarely resulted in infection, sporadic clusters of HPS probably will continue to occur even though individual cases will predominate.
Abstract 24: Novel STAT3 &amp; HDAC inhibitors that selectively target triple-negative breast cancer cell
Authors: Bocheng Wu
Journal: Cancer Research (2019)

Abstract Signal transducer and activator of transcription 3 (STAT3) is an oncogenetic transcriptional factor which can modulate cancer cells apoptosis. Stimulation of cancer cells by cytokines such as IL-6, INF-a, etc., can induce phosphorylation of STAT3, resulting in the translocation of p-STAT3 into the nucleus where it facilitates the expression of anti-apoptosis genes. This p-STAT3 anti-apoptotic activity is one drug resistance mechanism developed by cancer cells against chemotherapies including histone deacetylase inhibitors (HDACi). Pyrimethamine has been reported to inhibit STAT3 phosphorylation, mRNA transcriptional level, and STAT3-dependent cell viabilities. In this presentation, we disclosed novel pyrimethamine-based bifunctional STAT3-HDAC inhibitors as potential therapeutic agents for p-STAT3-dependent cancers. We will describe the design, synthesis and biological activities of STAT3-HDAC inhibitors. We will show that these bifunctional agents inhibit HDAC deacetylase activity and STAT3 phosphorylation. A subset of these compounds is more cytotoxic to MDA-MB-231, a triple-negative breast cancer cell line that is highly dependent on STAT3. Citation Format: Bocheng Wu. Novel STAT3 &amp; HDAC inhibitors that selectively target triple-negative breast cancer cell [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 24.
MIGRAINE
Authors: C. L. HARTSOCK
Journal: JAMA (1927)

It is with some hesitation that one attempts to add to the literature on a subject about which so much has already been written and about which so little is actually known. But when one is confronted almost daily with patients complaining of migraine and finds that only in the exceptional case has any attempt been made to establish a rational therapeutic regimen, the treatment having been limited, as a rule, to the relief of the immediate attack, one feels that any suggestion is worth while which may lead to a method of treatment that will give more satisfactory results both to the patient and to the physician. The apparently careless attitude of the physician toward migraine may possibly be explained in several ways: No dire consequences are associated with the disease, and therefore the preservation of the patient's general health does not demand that the attacks be prevented; the
Rituximab (Mabthera) Improves the Treatment Results of DHAP-VIM-DHAP and ASCT in Relapsed/Progressive Aggressive CD20+ NHL. A Prospective Randomized HOVON Trial.
Authors: Edo Vellenga, Annelise Notenboom, Mars van ‘t Veer, Josée Zijlstra, Willem E. Fibbe, Rien van Oers, Gustaaf W. van Imhoff, Elly Lugtenburg, P.C. Huijgens
Journal: Blood (2006)
Biotransformation Enzymes in the Rodent Nasal Mucosa: The Value of a Histochemical Approach
Authors: Matthew S. Bogdanffy
Journal: Environmental Health Perspectives (1990)

An increasing number of chemicals have been identified as being toxic to the nasal mucosa of rats.While many chemicals exert their effects only after inhalation exposure, others are toxic following systemic administration, suggesting that factors other than direct deposition on the nasal mucosa may be important in mechanisms of nasal toxicity.The mucosal lining of the nasal cavity consists of a heterogeneous population of ciliated and nonciliated cells, secretory cells, sensory cells, and glandular and other cell types.For chemicals that are metabolized in the nasal mucosa, the balance between metabolic activation and detoxication within a cell type may be a key factor in determining whether that cell type will be a target for toxicity.Recent research in the area of xenobiotic metabolism in nasal mucosa has demonstrated the presence of many enzymes previously described in other tissues.In particular, carboxylesterase, aldehyde dehydrogenase, cytochromes P-450, epoxide hydrolase, and glutathione S-transferases have been localized by histochemical techniques.The distribution of these enzymes appears to be cell-type-specific and the presence of the enzyme may predispose particular cell types to enhanced susceptibility or resistance to chemical-induced injury.This paper reviews the distribution of these enzymes within the nasal mucosa in the context oftheir contribution to xenobiotic metabolism.The localization of the enzymes by histochemical techniques has provided important information on the potential mechanism of action of esters, aldehydes, and cytochrome P-450 substrates known to injure the nasal mucosa.
Report of the Librarian
Authors: Henry R. Viets
Journal: New England Journal of Medicine (1954)

THE Librarian herewith presents his annual report, the sixteenth accounting of the state of the Library since he took office in 1938. This report covers the calendar year 1953, a year of increased use of the books and journals, with more readers than at any time in the last six years, In addition to the increase in service there was the usual growth of the Library in books and catalogued pamphlets, 378,897 items being made available to readers. It is of interest to notice the trends of the Library since 1936. The increase in size has been between 3000 and . . .
Smoking History
Authors: Robert N. Proctor
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ANTIVIVISECTIONISTS AND THE "BRITISH MEDICAL JOURNAL."
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
International Symposium on Cancer Biology and Therapeutics
Journal: JNCI Journal of the National Cancer Institute (1985)

Journal Article International Symposium on Cancer Biology and Therapeutics Get access JNCI: Journal of the National Cancer Institute, Volume 75, Issue 6, December 1985, Page 1147, https://doi.org/10.1093/jnci/75.6.1147-a Published: 01 December 1985
Gastrectomy
Authors: None Moynihan
Journal: BMJ (1935)

<b>BACKGROUND AND PURPOSE:</b> Vertebral osteomyelitis can have different imaging manifestations. The purpose of this study was to demonstrate the unusual MR imaging patterns of vertebral osteomyelitis with intraosseous lesions mimicking metastases. <b>MATERIALS AND METHODS:</b> From September 2000 to August 2007, 7 patients were selected from our data base of 214 patients with confirmed vertebral osteomyelitis and MR images. All of those having misinterpreted MR imaging reports and unusual imaging patterns were analyzed. The presence of a peripheral curvilinear area of low signal intensity in an osseous lesion (the rim sign) and a peripheral rim of high signal intensity on T2-weighted images around an osseous lesion (the halo sign) was evaluated. Follow-up MR imaging studies were performed in all patients. <b>RESULTS:</b> The patients were 5 men and 2 women, with an age range of 42–80 years. MR imaging findings of those with vertebral osteomyelitis showed a solitary lesion in 2 and multiple lesions in 5 patients. The intraosseous lesions revealed low signal intensity on T1-weighted images, mixed or high signal intensity on T2-weighted images, high signal intensity on short τ inversion recovery images, and global or marginal enhancement. The rim sign was found in 6 (86%) patients; halo sign, in 7 (100%); preserved intervertebral disks, in 7 (100%); and limited paraspinal or epidural inflammation, in 6 (86%). Images of all patients demonstrated healing or almost healed changes on the follow-up MR imaging studies. <b>CONCLUSION:</b> Vertebral osteomyelitis can have MR imaging patterns mimicking osseous metastases. Recognition of these unusual imaging manifestations, together with clinical and histopathologic analysis, may aid in reaching the correct diagnosis.
ORIGINAL INVESTIGATIONS ON THE NATURAL HISTORY, (SYMPTOMS AND PATHOLOGY) OF YELLOW FEVER. 1854-1894.
Authors: JOSEPH JONES
Journal: JAMA (1895)

<h3>Chapter X.</h3><h3>Case 2.</h3> —Yellow fever, black vomit, death. John Sullivan entered Charity Hospital Oct. 8, 1873, about fourth day of disease, great congestion of capillaries of face, neck and extremities, jaundice, hiccough, nausea, pain in head especially in frontal region. Pulse 82, respiration 28, temperature of axilla 98.2. October 9, 8 A.M., pulse 72, respiration 28, temperature 97.1; black vomit. The liquid ejected in abundance is of low specific gravity and strong acid reaction and contains numerous dark specks and flakes resemblihg coffee grounds. Hands feel cold. Great congestion of peripheral capillaries. Jaundice; conjunctiva of eyes congested and yellow; tongue red at tip and edges. Gums very red with some oozing of blood. Patient says that he has pain everywhere. Urinary excretion suppressed. 8 P.M., pulse 80, respiration 30, temperature 99.2. Spits up black vomit all over the bed. October 10, 8 A.M., pulseless, respiration 40; temperature 92.2. Suppression