DILUTION ACIDOSIS
Authors: G T SHIRES, J HOLMAN
Journal: Annals of Internal Medicine (1948)

Article1 March 1948DILUTION ACIDOSISGEORGE T. SHIRES, JAMES HOLMAN, M.D.GEORGE T. SHIRESSearch for more papers by this author, JAMES HOLMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-28-3-557 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn studying the effects of rapid saline administration upon circulation and respiration in the dog, a constant and progressive acidosis of arterial blood has been noticed. This effect has been noticed by Odaiva,1Essen,2Skelton,3and Van Slyke,4but apparently this concept has not been advanced or recognized in the recent literature. Since it is a very common hospital practice for physicians to administer isotonic sodium chloride (.9 per cent NaCl) intravenously in many disease states, it was thought worthwhile to report the effect and action of this administration upon blood pH. This administration is an attempt on the part...Bibliography1. ODAIVA T: Influence of some neutral salt solutions, intravenously administered, on the alkali reserve of the blood, Tohokee Jr. Exper. Med., 1923, iv, 523. Google Scholar2. ESSENKOUNDERSPORGES HFO: Die Beziehungen der CO2 Spannung der Alveolarluft zu den Chloriden des Blutserums, Wien. Arch. inn. Med., 1923, v, 499. Google Scholar3. SKELTON H: The storage of H2O by various tissues of the body, Arch. Int. Med., 1922, xl, 140. Google Scholar4. VAN SLYKEWUMCLEAN DDHFC: Studies of gas and electrolyte equilibria in the blood. V. Factors controlling the electrolyte and water distribution in the blood, Jr. Biol. Chem., 1923, lvi, 765. CrossrefGoogle Scholar5. PETERSVAN SLYKE JDD: Quantitative clinical chemistry: Interpretations, Vol. I, 1946, Williams & Wilkins Co., Baltimore. Google Scholar6. GESSELL R: The chemical regulation of respiration, Physiol. Rev., 1925, v, 551. CrossrefGoogle Scholar7. HARRISON TR: Failure of the circulation, 1939, Williams & Wilkins Co., Baltimore. Google Scholar8. HEYERHOLMANSHIRES HJGT: Changes in respiratory efficiency and dynamics in experimental pulmonary congestion. To be published. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Dallas, Texas*Received for publication August 20, 1947.From the Department of Internal Medicine, Southwestern Medical College, Dallas, Texas.†Done during the tenure of a Life Insurance Medical Research Student Fellowship.‡Done during the tenure of a Fellowship provided by the William S. Merrell Company. 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