tbuckley/cabot-search huggingface dataset:
American Surgeon, Baltimore
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Concurrent or layered treatment with radium-223 (Ra-223) and enzalutamide (Enza) or abiraterone plus prednisone/prednisolone (Abi/pred): A retrospective study of real-world clinical outcomes in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC).
Authors: Neal D. Shore, A. Oliver Sartor, Cora N. Sternberg, Fred Saad, Bertrand F. Tombal, Kurt Miller, Jan Kalinovsky, XiaoLong Jiao, Krishna Tangirala, Celestia S. Higano
Journal: Journal of Clinical Oncology (2019)

5026 Background: In clinical practice, Ra-223 is often combined with Enza or Abi/pred. ERA 223 (NCT02043678) showed increased fracture risk with concurrent Ra-223+Abi/pred. We assessed real-world symptomatic skeletal events (SSEs) and overall survival (OS) of pts with mCRPC who received concurrent or layered Ra-223+Enza or Abi/pred. Methods: Patients with mCRPC treated with Ra-223 in US cancer clinics from 1/01/2013 to 6/30/2017 were identified from a Flatiron prostate cancer registry of electronic health records. Treatment initiation defined subgroups: concurrent (both started within 30 days) or layered (1 started ≥30 days after the other). Baseline (BL) was the first dose of Ra-223. Descriptive analysis was performed for BL characteristics, SSEs, and OS (Kaplan–Meier). Results: Of 625 pts treated with Ra-223, 48% received Ra-223+Enza or Abi/pred. Layered treatment was more common (73%) than concurrent (27%). BL characteristics and clinical outcomes were summarized [Table]. Conclusions: In a real-world setting, Ra-223+Enza or Abi/pred treatment was mainly layered. SSE rates with layered vs concurrent Ra-223+Abi/pred varied between subgroups; results must be treated cautiously given small pt numbers and a non-randomized study. The ongoing PEACE III trial is investigating concurrent Ra-223+Enza; a Phase III study (ESCALATE) exploring layered Ra-223+Enza is planned. [Table: see text]
Determination of 2-Acetylaminofluorene Adducts by Immunoassay
Authors: Miriam C. Poirier, B'Ann True, Brian A. Laishes
Journal: Environmental Health Perspectives (1983)

Antisera elicited in rabbits were used in radioimmunoassay (RIA) and enzyme-linked immunosorbent assay (ELISA) to determine femtomole quantities of deoxyguanosin-(8-yl)-acetylaminofluorene (dg-8-AAF) and deoxyguanosin-(8-yl)-aminofluorene (dg-8-AF). These adducts have been monitored in liver and kidney DNA of male Wistar-Furth rats fed 0.02% or 0.04% 2-acetylaminofluorene (2-AAF) either continuously or for a limited time followed by an interval on control diet. After 24 hr of 0.02% 2-AAF feeding, substantial levels of binding (80 fmole/μg DNA) were observed in liver DNA and increased with time, reaching a plateau of approximately 230 fmole/μg DNA at 30 days and thereafter. During the first week of continuous feeding about 80% of the total C-8 adducts in the liver DNA were deacetylated (dG-8-AF). By 25-60 days, dG-8-AF represented 97-100% of all C-8 adducts as measured by RIA and confirmed by HPLC. Values for C-8 adduct formation in kidney DNA were severalfold lower than in liver and dG-8-AF represented &gt;90% of C-8 adducts at all times studied. In removal or repair experiments, rats were fed 2-AAF for 3, 7 or 28 days, the 2-AAF diet was discontinued and the liver adducts assayed after intervals on control diet. When dietary 2-AAF administration was for 3 or 7 days, removal of adducts was efficient and almost complete by 28 days on control diet, with preferential retention of dG-8-AF. However, when dietary 2-AAF administration was for 28 days, adduct levels were higher, the repair capacity was saturated and the removal of C-8 adducts was not complete after control diet for a 28-day interval. In a preliminary experiment when [3H]-2-AAF was fed for 3 days, after 25 days of 0.02% 2-AAF, the rates of newly formed adduct formation and removal were similar to those observed for the initial 3 days of 2-AAF feeding. These results demonstrate the predominance and persistence of dG-8-AF in liver and kidney DNA of 2-AAF-fed rats and suggest that the repair capacity of the whole rat liver was not diminished after 1 month of 2-AAF feeding.
Marginal Medicine
Authors: R D Lamm
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CD20‐positive adult T‐cell leukemia
Authors: Masaki Yasukawa, Junko Arai, Miki Kakimoto, Ikuya Sakai, Hidehisa Kohno, Shigeru Fujita
Journal: American Journal of Hematology (2001)

A 67-year-old woman was admitted to our hospital because of lymphadenopathy and lymphocytosis. Monoclonal integration of HTLV-I provirus DNA was detected, and a diagnosis of adult T-cell leukemia (ATL) was made. Flow cytometry revealed that the ATL cells expressed CD20 as well as T-cell-associated antigens, and expression of CD20 mRNA was also demonstrated. A novel T-cell subpopulation expressing CD20 molecules has recently been identified. This is the first report of CD20-positive ATL, suggesting that HTLV-I can infect and transform CD20-positive T cells. Am. J. Hematol. 66:39–41, 2001. © 2001 Wiley-Liss, Inc.
Abstract O.21: Inositol 1,4,5 triphosphate 3- kinase C regulates NLRP3 Inflammasome activation in Kawasaki disease
Authors: Martin P Alphonse, Trang T Duong, Chisato Shimizu, Long T Hoang, Brian W McCrindle, Alessandra Franco, Stephane Schurmans, Dana J Philpott, Martin L Hibberd, Jane C Burns, Taco W Kuijpers, Rae S Yeung
Journal: Circulation (2015)

Background: ITPKC controls calcium homeostasis and was identified in genome-wide studies to be associated with susceptibility and severity of KD. NLRP3 is activated by danger signals, leading to inflammasome activation and release of IL-1beta and IL-18. Ca 2+ mobilization mediates NLRP3 activation. We studied the contribution of ITPKC and NLRP3 inflammasome activation in KD. Methods: Cytokine levels were measured using ELISA. Gene expression was assayed using Illumina HumanHT-12v4. EBV-transformed B-cell lines from KD patients with different ITPKC genotypes were used to study the gene and protein expression and Ca 2+ flux using qRT-PCR, Western blot analysis, and FACS respectively. In vivo and in vitro analyses from ITPKC-deficient and wildtype mice were performed using ELISA, spinning disc confocal and Westerns, to determine cytokine release, Ca 2+ flux and protein expression responses respectively. Results: Children with KD show increased circulating IL-1beta, IL-18, IL-1RA and IL18BP protein during acute phase of KD (KD n=48, febrile controls n=41 p&lt;0.001). NLRP3 and its associated inflammasome complex, and the IL-1[[Unsupported Character - Symbol Font &amp;#61538;]] and IL18 receptor genes were up-regulated nearly two fold during the acute KD compared to matched convalescent controls (n=171, p&lt;0.001). Pathway analysis showed specific up-regulation of NLRP3 related genes. The KD-associated genetic polymorphism in ITPKC (rs28493229) is functional, directly modulating [Ca 2+ ] i mobilization resulting in NLRP3 activation and increased production of IL-1beta and IL-18, as demonstrated by gene expression, circulating protein levels and functional assays of PBMCs and immortalized cell lines from affected children. These biologic data are partnered with evidence showing resistance to IVIG therapy in those with the ITPKC polymorphism associated with the highest basal and stimulated [Ca 2+ ] i levels. Studies using ITPKC-deficient mice in an animal model of KD support the molecular, cellular and clinical findings in affected children. Significance: ITPKC regulates NLRP3 activation via control of [Ca 2+ ] i mobilization, directing production of IL-1beta and IL-18, pointing to the key role of calcium mobilization in the immunopathogenesis of KD.
The effect of chyme reinfusion on the bile salt/fibroblast growth factor 19 signaling axis in intestinal failure patients with a temporary jejunal double enterostomy
Authors: Xinwei Chang, Denis Picot, Kiran Koelfat, Sander M.J. van Kuijk, Sabrina Layec, Marie Carsin, Laurence Dussaulx, Eloi Seynhaeve, Florence Trivin, Laurence Lacaze, Ronan Thibault, Frank Schaap, Steven Olde Damink
Journal: Journal of Hepatology (2020)
Tinnitus
Authors: Veneta Masson
Journal: Annals of Internal Medicine (2016)

Ad Libitum7 June 2016TinnitusVeneta Masson, RN, MAVeneta Masson, RN, MAFrom Washington, DC.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M16-0241 Audio Reading - “Tinnitus” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Tinnitus," by V. Masson. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Mine is pulsatile—I hear my own heartbeat24/7not like a drumbut high-pitched and bentlike the sound of tiny sirens passing by.At night it saves me from counting sheep.By day it masksambient noiseintrusive thoughtsdisquieting silence.I've grown to like listening to my heart,wish I could have done it earlier in lifewhen it was harder to hear,near impossible to feel.Call it a gift of agea symptom of mortalityor how about this—a doorbellwhose insistent ringwill one day be answered.And then? I'll glide throughthe wide open door in silence. Author, Article, and Disclosure InformationAffiliations: From Washington, DC. PreviousarticleNextarticle Advertisement Audio Reading - “Tinnitus” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Tinnitus," by V. Masson. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 7 June 2016Volume 164, Issue 11Page: 763KeywordsHeartMortalityTinnitus ePublished: 7 June 2016 Issue Published: 7 June 2016 Copyright & PermissionsCopyright © 2016 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Opioid Rotation in the Management of Refractory Cancer Pain
Authors: Rose Anne Indelicato, Russell K. Portenoy
Journal: Journal of Clinical Oncology (2002)

Article Tools THE ART OF ONCOLOGY: WHEN THE TUMOR IS NOT THE TARGET Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2002.20.1.348 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 11773191 Opioid Rotation in the Management of Refractory Cancer Pain Rose Anne IndelicatoxRose Anne IndelicatoSearch for articles by this author , Russell K. PortenoyxRussell K. PortenoySearch for articles by this author Show More From the Department of Pain Medicine and Palliative Care, Beth Israel Medical Center, New York, NY. https://doi.org/10.1200/JCO.2002.20.1.348 First Page Full Text PDF Figures and Tables © 2002 by American Society of Clinical Oncology
Abstract 46: The Association between Acute Mental Stress and Changes in Left Atrial Electrophysiology
Authors: Wesley T O’Neal, Zakaria Almuwaqqat, Muhammad Hammadah, Mohamad M Gafeer, Naser Abdelhadi, Kobina Wilmot, Ibhar Al Mheid, Ronnie Ramadan, J. D Bremmer, Michael Kutner, Elsayed Z Soliman, Amit J Shah, Arshed A Quyyumi, Viola Vaccarino
Journal: Circulation (2017)

Background: Acute stress may trigger atrial fibrillation, but the mechanisms are not clear. We hypothesized that acute mental stress results in abnormal atrial remodeling via electrophysiologic effects. Methods: We examined our hypothesis in 168 patients (mean age=63±8.7 years; 74% men; 65% Caucasian) with stable coronary heart disease who underwent mental (speech task) stress testing. PTFV 1 duration (ms) times the value of the depth (μV) of the downward deflection (terminal portion) of the median P-wave in lead V 1 , and was automatically measured on digital electrocardiograms (ECG) at rest, stress, recovery. Electrocardiographic left atrial abnormality was defined as P-wave terminal force in lead V1 (PTFV1) ≤ -4000 μV*ms. The mean values of PTFV 1 during stress and recovery were compared with rest. Additionally, the percentage of participants who had left atrial abnormality during stress and recovery was compared with those at rest. Results: The mean PTFV 1 at rest was -2857±2459 μV*ms. There were 51 (30%) participants who had baseline left atrial abnormality. Compared with rest, PTFV 1 became more negative with stress [mean change=-474, 95%CI=(-103, -845); p=0.013] and during recovery [mean change=-420, 95%CI=(-79, -761); p=0.016]. A larger percentage of participants showed left atrial abnormality during stress (n=63, 38%) and recovery (n=67, 40%) compared with rest. Similar changes in PTFV 1 with stress [mean change=-833, 95%CI=(-372, -1295); p&lt;0.001] and recovery [mean change=-796, 95%CI=(-389, -1204); p&lt;0.001] were observed when we excluded those with baseline left atrial abnormality. No differences were noted in the PTFV 1 response based on age, gender, race, or hemodynamic response to stress. Conclusion: Acute mental stress alters left atrial electrophysiology, as measured by PTFV 1 , suggesting that stressful situations promote adverse atrial remodeling. This possibly explains the poor cardiovascular outcomes associated with acute mental stress that are triggered by left atrial abnormalities such as atrial arrhythmias and stroke.
Gastroenteritis greatly increases risk of irritable bowel syndrome
Journal: BMJ (1999)

Impaired fertility and testicular cancer share common causes Indicators of male reproductive hazards have reportedly increased in many populations-for example, incidence of testicular cancer, low sperm counts, the dizygotic twinning rate, and the secondary sex ratio.It is unknown whether different indicators tend to occur together in individual men or whether the observed trends (if real) are just coincidental phenomena.On p 559 Møller and Skakkebaek report the results from a population based case-control study in Denmark, which shows a strong association in men between subfertility and subsequent risk of testicular cancer.The authors suggest that these results are consistent with the hypothesis that common causal factors exist that affect both a man's ability to reproduce and his probability of developing testicular cancer. Chinese herbal creams may contain steroidsPatients with eczema often report success with Chinese herbal creams.Keane et al (p 563) decided to analyse the content of creams used by their patients and found that most contained dexamethasone in various concentrations.The preparations were often supplied in unlabelled containers without clear instructions.The authors call for closer regulation of herbal medicines to ensure adequate labelling and to prevent dispensing of unlicensed products in the guise of herbal treatments.
Questions and Comments
Journal: BMJ (1960)

Any Questions.?We puiblish below a selection of those questions and answers which seem of general interest.It is regretted that it is not possible to supply answers to all questions submitted.Oral Contraceptives Q.-What is the present position about oral contraceptives ?A.-Extensive data have been collected on the use of a mixture of norethynodrel and ethinyloestradiol-3-methyl ether (" enavid ") as an oral contraceptive, and very much less experience with other agents has also accumulated.The facts indicate that enavid, in a dose of 5 or 10 mg.daily by mouth, given from the fifth day of the menstrual cycle for 20 days, inhibits ovulation and is highly effective in preventing conception.It is probable, though not yet certain, that a daily dose of 2.5 mg. is just as effective.Approxi- mately 15% of patients experience side-effects of varying degree, including nausea, vomiting, headache, dizziness, and bloating.In a few, the symptoms are of sufficient severity to make continuation of treatment impossible, but in most patients they are relatively mild and soon wear off, especially if the tablets are taken at night with a little milk.Some irregularity of the periods may be found at the beginning of treatment, but in most cases the periods soon settle down and are trouble-free (even when, for example, there may previously have been menorrhagia or dysmenorrhoea).No significant ill-effects have been observed in several hundred patients, some of whom have taken the treatment for over three years, but obviously it will require more than 20 years' observation to be sure that long-term ill-effects are nonexistent.Women who have given up the tablets in order to conceive again have succeeded in doing so, if anything more easily than might have been expected from the past history, and when, through failing to follow the instructions correctly, pregnancies.have occurred while taking the tablets, no unexpected foetal abnormalities have been seen.Undoubtedly enavid is an effective oral contraceptive, REFERENCE
Effects of Postoperative Mediastinal Radiation on Completely Resected Stage II and Stage III Epidermoid Cancer of the Lung
Journal: New England Journal of Medicine (1986)

We randomly assigned 230 patients with resected Stage II or III epidermoid (squamous-cell) lung cancer to receive postoperative adjuvant radiotherapy or no adjuvant treatment. Careful intraoperative staging had been performed in all patients. Before randomization, patients were stratified according to stage, weight loss, age, and institution. Prognostic variables, such as stage, weight loss, age, nodal-disease status, and tumor status, were equally distributed between the two groups. The mean time from randomization to analysis was 3.5 years among the 210 eligible patients. There was no evidence that radiotherapy improved survival, and although recurrence rates appeared to be somewhat reduced among patients assigned to radiotherapy, these decreases were not statistically significant. However, radiotherapy did produce a striking and significant reduction in recurrences to the ipsilateral lung and mediastinum. Moreover, overall recurrence rates were reduced by radiotherapy in patients with N2 disease (P less than 0.05), although even this subgroup had no evidence of improved survival. We conclude that radiotherapy can reduce local recurrences after resection of epidermoid carcinoma of the lung, but that it does not increase survival rates.
JAMA Pediatrics
Authors: Phil Fontanarosa, Annette Flanagin, Brenda Gregoline, Tracy Frey, Shannon Sparenga, Nicole Balin, Miriam Cintron, Paul Ruich, Diane Cannon, Connie Manno, Fred Marshall, Laura Copyreaders, Catherine Adamczyk, Stephanie Alden, Jan Beckmeyer, Mary Clavey, Roya Coerver-Connolly, Laura Khatiblou, Juliann King, Donna Tarsney, Caroline Thordsen, Wanda Assistant, Larry Bryant, Monica Mungle, Elaine Williams, Lenette Gardner-Gullens, Fanny Brown, Paul Frank, Rachell Lozano, Michaela Mark, Kathryn Muskovich, Kate Pezalla, Gale Saulsberry, Michael Berkwits, Michelle Kurzynski, Eric Butkus, Christopher Hastings, Craig Mccaffrey, Reuben Rios, Ronna Henry, Joshua Bird, David Song, Deputy Livingston, Thomas Cole, Marla Hall, Deanna Willis, Yolanda Davis, Joseph Thornton, Preeti Malani, Deanna Bellandi, Jim Periodical, Thomas Staff, Monica Smith, Jeffery Bonistalli Manager, Kathy Russell, Mirna Monal, Tim Melroy, Thalia Moss, Mike Harvey, Susan Henning, Mark Thornbury, Tricia Castellano, Saskia Bolore, Gretchen Linder, Brian Mccartney, David Baum, Rebecca Haas, Christine Hearne, Irma Millie, Lara Marketing, Matt Herron, Elizabeth Solaro, Geoffrey Flick, Paul Gee Managers, Rick Bell, Michael Mcgraw, Sara Nagy, Romando Rossini, Stacy Staff, Millette Jackson-Bates, Karen Adams-Taylor, Karl Elvin, Sue Sherrill, Brian Shields Managers, David Antos, Chris Borden, Debbie Camp, Lydia Cruz, Scott Curl, Diane Darnell, Colleen Kelly, Chris Meyer, Jaye Mize, Annemarie Neff, J Neff, Sean O'donnell, Sean Ohlson, Phil O'leary, Susan Price, Denise Steinhauser, Production Services, Kim Boler, Rhonda Brown, Timothy Burke, Daniel Degroot, Jordynn Farrar, Euwanaha Joiner-Smith, Cindy Rendlen, Ellen Yoshihara, Circulation Services, Julie Burton, Dexter Golden, Erin Hinchcliff, Noemi Rivera, Geneine Van, Someren Composition, New Media, Gail Barrett, Regina Brownlee, Amanda Camino, Brenda Chandler-Grayer, Amy Evers, Teri Hutchison, Mary Kuranda, Joshua Lampinen, Patricia Panek, La Son, Diggs Sledge, George Thomson Graphics, Joe Amft, Maria Duda, Fred Furtner, Carolyn Hall, Maria Kowalkowski, Proofreading Carol, Joy Farrell, Daniel James, Judith Literskis, Teresa Omiotek, James Madara, Bernard Hengesbaugh, Dimitri Christakis, Washington Joffe, Ron Keren, Suzanne Shuey, Benjamin French, Peter Cummings, Samir Shah, Howard Bauchner, Frederick Rivara, Joyce Lee, Ann Arbor, Jay Berry, Cherrie Boston, San Boyer, Robert Bradley, Maria Britto, John Campo, Aaron Carroll, Indiana Frank, Joseph Chaloupka, Mitchell Cohen, Chris Feudtner, Kathleen Janz, Iowa City, Terry Klassen, Michigan Michelle, Huckaby Lewis, Aaron Milstone, Maryland Baltimore, Shawn Rangel, Lisa Saiman, New York, York Samir, Martha Sola-Visner, Jean-Claude Carel, Shabir Madhi, Ben Marais, Frank Oberklaid, Susan Sawyer, Joan-Carles Surís
Journal: JAMA Pediatrics (2014)