tbuckley/cabot-search huggingface dataset:
Alois Alzheimer (1864-1915) Neurohistopathologist
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Characteristics of Nonsmoking Women Exposed to Spouses Who Smoke: Epidemiologic Study on Environment and Health in Women from Four Italian Areas
Authors: Francesco Forastiere, Sandra Mallone, Elena Lo Presti, Sandra Baldacci, Francesco Pistelli, Marzia Simoni, Annarita Scalera, Marzia Pedreschi, Riccardo Pistelli, Giuseppe Corbo, Elisabetta Rapiti, Nera Agabiti, Sara Farchi, Salvatore Basso, Luigi Chiaffi, Gabriella Matteelli, Francesco Di Pede, Laura Carrozzi, Giovanni Viegi
Journal: Environmental Health Perspectives (2000)

The aim of this study was to evaluate whether risk factors associated with cardiovascular or respiratory diseases and lung cancer occur differently among nonsmoking women in Italy with and without exposure to environmental tobacco smoke (ETS) from husbands that smoke. We performed a cross-sectional study of 1,938 nonsmoking women in four areas of Italy. Data on respiratory and cardiovascular risk factors and on diet were collected using self-administered questionnaires. Medical examinations and blood tests were administered; urine cotinine levels were measured. Nonsmoking women ever exposed to husbands' smoking were compared with unexposed women for several factors: education, husband's education, household crowding, number of children, current or past occupation, exposure to toxic substances at work, parental diseases, self-perceived health status, physician-diagnosed hypertension, hypercholesterol, diabetes, osteoporosis, chronic respiratory diseases, blood pressure medications, lifestyle and preventive behaviors, dietary variables, systolic and diastolic blood pressure, body mass index, waist-hip ratio, triceps skin folds, plasma antioxidant (pro-) vitamins (- and ss-carotene, retinol, l-ascorbic acid, -tocopherol, lycopene), serum total and HDL cholesterol, and triglycerides. Women married to smokers were more likely to be less educated, to be married to a less educated husband, and to live in more crowded dwellings than women married to nonsmokers. Women married to smokers were significantly less likely to eat cooked [odds ratio (OR) = 0.72; 95% confidence interval (CI), 0.55-0.93] or fresh vegetables (OR = 0.63; CI, 0.49-0.82) more than once a day than women not exposed to ETS. Exposed women had significantly higher urinary cotinine than unexposed subjects (difference: 2.94 ng/mg creatinine). All the other variables were not more prevalent among exposed compared to unexposed subjects. The results regarding demographic factors are easily explained by the social class distribution of smoking in Italy. A lower intake of vegetables among exposed women in our study is consistent with the available literature. Overall, our results do not support previous claims of more frequent risk factors for cardiovascular and pulmonary diseases among ETS-exposed subjects. In Italy, as elsewhere in Europe and North America, women who have never smoked but are married to smokers are likely to be of lower social class than those married to never-smokers. However, once socioeconomic differences are considered, the possibility of confounding in studies on the health effects of ETS is minimal.
Updated data from an ongoing study with ADP-A2AFP spear T-cells
Authors: Tim Meyer, Bruno Sangro, Amit Mahipal, Lipika Goyal, Matthew J Frigault, Debashis Sarker, Lynn G Feun, Petr F Hausner, Mitesh J Borad, Kit Wong, Anthony El-Khoureiry, Richard Finn, Ahmed Kaseb, Benjamin R Tan, Fiona Thistlethwaite, Bassel El-Rayes, Jordi Bruix, Joana Senra, Svetlana Fayngerts, Jennifer Sampson, Elliot Norry
Journal: Journal of Hepatology (2020)
Role of metals in carcinogenesis. Experimental studies in whole animal bioassay.
Authors: Thomas Clarkson, Robert Goyer, Gerald Fisher, Arthur Furst, George Kazantzis, Yasushi Kodama, Marvin Kuschner, Trent Lewis, Paul Nettesheim, Andrew Reeves, Samuel Shibko, F Sunderman
Journal: Environmental Health Perspectives (1981)
The Scientific Program
Journal: JAMA (1978)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Hand
Authors: Robert M. McCormack
Journal: JAMA (1971)

This book, an enlargement of a chapter in<i>Campbell's Operative Orthopaedics</i>, is now published as a separate volume for use by all plastic, orthopedic, and general surgeons interested in the surgery of the hand. An excellent handbook, written by an experienced hand surgeon, it is noteworthy for its clarity of presentation, accurate diagnostic principles, careful practical planning and technical descriptions. Probably nowhere can one find a more extensive compilation of the best illustrations and useful proven techniques of hand surgery than in this book. An outstanding feature is the extensive bibliography, of almost 800 separate references, classified according to the sections of the book, and comprising the most extensive practical bibliography of the English literature. The subject matter has been subdivided into 18 practical sections, so that it can be easily applied to daily problems in surgery of the hand. The descriptions of surgical techniques and after care are detailed
TRAVEL NOTES.VII. A WINTER SEMESTER.
Authors: LEWELLYS F. BARKER
Journal: JAMA (1904)

For a certain period the globe-trotting method of travel may please and satisfy, but after a time it palls. When picture galleries have been seen by the dozen, palaces by the score, and churches by the hundred, the esthetic sense becomes over-saturated and refuses to take up more. The almentary tract, too, rebels against the bustle of the railway station and the continuance of life in "grand hotels." The centers of benevolence gradually undergo cloudy swelling, hypertrophy with tendency to degeneration, through enforced over-activity in the matter of<i>la buonamano</i>. Desultory visiting of hospitals and physicians, easily stimulating for a time, meets with an ever-rising threshold as the weeks pass. The body craves a more regular life and the mind demands greater intensity and less diversity of occupation. It is, therefore, with a feeling of relief that, entering Germany from Italy
ESGE Newsletter
Journal: Endoscopy (2013)

Amsterdam Live Endoscopy 2013 December 16, 2013 Amsterdam, The NetherlandsTogether with the entire team of the department of Gastroenterology & Hepatology at AMC with top-endoscopists from around the globe, Amsterdam Live Endoscopy combines teaching of high-end therapeutic interventions with teaching of the more routine diagnostic and therapeutic interventions demonstrated in the most optimal way. The meeting is proud to have a very lively interaction between faculty and participants, either through perfect audio-lines or one on one during breakout sessions as well as coffee- and tea breaks. www.amsterdamendoscopy.com Information: Ms Van der Woude epgs@amc.uva.nl
Abstract 5393: Exosomal microRNA profiles in peritoneal fluids as a therapeutic biomarker for peritoneal metastasis of gastric cancer
Authors: Hideyuki Ohzawa, Yuko Kumagai, Hironori Yamaguchi, Yoshinori Hosoya, Naohiro Sata, Joji Kitayama
Journal: Cancer Research (2018)

Abstract Background: Repeated intraperitoneal chemotherapy (IPC) using taxane is highly effective for peritoneal metastasis. Peritoneal fluids are supposed to contain various factors derived from tumor cells seeded in peritoneal cavity. This study aimed to explore possible biomarkers for suitable IPC using exosomal miRNA profiles derived from malignant ascites or peritoneal lavages. Methods: Peritoneal fluid samples were obtained from 11 patients with peritoneal metastasis (PM+) and 14 patients who received gastrectomy for early gastric cancer (PM-). Exosomal fractions were isolated using ultracentrifuge method and total RNAs were extracted. The pooled RNA samples in both groups were mixed and expression of miRNAs were analyzed using miRNome miScript miRNA PCR Array (QIAGEN). Based on these results, we constructed the custom miRNA PCR panel and evaluates expression of miRNAs in individual samples. Results: The comprehensive PCR analysis showed that total of 56 and 54 miRNAs were strongly expressed in exosomes in PM+ and PM- peritoneal fluid sample, respectively. In analysis of individual samples, 7 upregulated miRNAs (miR-150-5p, miR-223-3p, miR-204-5p, miR-720, and miR-92a, miR-21-5p, miR-4301, and miR-342-3p) and 3 downregulated miRNAs (miR-29a-3p, miR-29b-3p, and miR-29c-3p) were identified in PM+ samples. Conclusion: In patients who receive IPC, peritoneal fluids can be repeatedly obtained from peritoneal access port. Exosomal miRNA profiles of peritoneal fluid samples might be a useful biomarker to determine the therapeutic efficacy as well as to predict the outcome in those patients with peritoneal metastasis. Citation Format: Hideyuki Ohzawa, Yuko Kumagai, Hironori Yamaguchi, Yoshinori Hosoya, Naohiro Sata, Joji Kitayama. Exosomal microRNA profiles in peritoneal fluids as a therapeutic biomarker for peritoneal metastasis of gastric cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 5393.
BACTERIA IN PREPARED INFANT FOODS
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
New Bioethics Council Offers No Recommendations
Authors: B. Vastag
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pretransplant rifaximin administration reduces posttransplant liver injury and early allograft dysfunction in mouse and human liver transplantation
Authors: Takahiro Ito, Shoichi Kageyama, Kojiro Nakamura, Hirofumi Hirao, Kentaro Kadono, Hidenobu Kojima, Ronald Busuttil, Fady M. Kaldas, Jerzy Kupiec-Weglinski
Journal: Journal of Hepatology (2020)
Letter: Effect of methohexitone on infants delivered by caesarean section.
Authors: R Palmer
Journal: BMJ (1974)

or, unless the doctor is a 'person about the deceased' (see iv)), to the coroner."It is regrettable that there is no authoritative definition of the vague and archaic phrase "person about the deceased," but it seems likely that it must mean someone, such as next of kin, who is in close daily contact with the patient before death.The doctor may be the ,ppropriate person, or the only such person in certain circumstances.It would be unfortunate if Dr.
Effects of statins in patients with chronic kidney disease: meta-analysis and meta-regression of randomised controlled trials
Journal: BMJ (2009)

Objective To analyse the benefits and harms of statins in patients with chronic kidney disease (pre-dialysis, dialysis, and transplant populations).Design Meta-analysis.Data sources Cochrane Central Register of Controlled Trials, Medline, Embase, and Renal Health Library (July 2006).Study selection Randomised and quasi-randomised controlled trials of statins compared with placebo or other statins in chronic kidney disease.Data extraction and analysis Two reviewers independently assessed trials for inclusion, extracted data, and assessed trial quality.Differences were resolved by consensus.Treatment effects were summarised as relative risks or weighted mean differences with 95% confidence intervals by using a random effects model.Results Fifty trials (30 144 patients) were included.Compared with placebo, statins significantly reduced total cholesterol (42 studies, 6390 patients; weighted mean difference -42.28 mg/dl (1.10 mmol/l), 95% confidence interval -47.25 to -37.32), low density lipoprotein cholesterol (39 studies, 6216 patients; -43.12 mg/dl (1.12 mmol/l), -47.85 to -38.40), and proteinuria (g/24 hours) (6 trials, 311 patients; -0.73 g/ 24 hour, -0.95 to -0.52) but did not improve glomerular filtration rate (11 studies, 548 patients; 1.48 ml/min (0.02 ml/s), -2.32 to 5.28).Fatal cardiovascular events (43 studies, 23 266 patients; relative risk 0.81, 0.73 to 0.90) and non-fatal cardiovascular events (8 studies, 22 863 patients; 0.78, 0.73 to 0.84) were reduced with statins, but statins had no significant effect on all cause mortality (44 studies, 23 665 patients; 0.92, 0.82 to 1.03).Meta-regression analysis showed that treatment effects did not vary significantly with stage of chronic kidney disease.The side effect profile of statins was similar to that of placebo.Most of the available studies were small and of suboptimal quality; mortality data were provided by a few large trials only.Conclusion Statins significantly reduce lipid concentrations and cardiovascular end points in patients with chronic kidney disease, irrespective of stage of disease, but no benefit on all cause mortality or the role of statins in primary prevention has been established.Renoprotective effects of statins are uncertain because of relatively sparse data and possible outcomes reporting bias.
Carbenicillin-associated hypokalemic alkalosis
Authors: S. V. Cabizuca
Journal: JAMA (1976)

IN 1968, Brunner and Frick reported severe metabolic alkalosis and hypokalemia in patients receiving large doses of penicillin G sodium.<sup>1</sup>It was suggested that penicillin promoted urinary potassium excretion by acting as a nonreabsorbable anion. Subsequently, correspondence in the medical literature implicated carbenicillin as another possible cause of hypokalemic alkalosis.<sup>2-4</sup>We report here the development of hypokalemia, hypochloremia, and metabolic alkalemia during the course of intravenous administration of carbenicillin disodium in a patient with pulmonary<i>Pseudomonas</i>infection. Serial arterial blood gas studies clearly demonstrated metabolic alkalosis in this patient. <h3>Report of a Case</h3> A 61-year-old woman had a recent thoracotomy and biopsy of a mass that demonstrated squamous cell carcinoma of the right upper lobe with metastases to the pleura and regional lymph nodes. After a week's course of postoperative radiation therapy, there was an onset of fever and a productive cough. Two sputum cultures were positive for
Gene Mutations and Treatment Outcome in Chronic Lymphocytic Leukemia: Results From the CLL8 Trial
Authors: Stephan Stilgenbauer, Raymonde Busch, Andrea Schnaiter, Peter Paschka, Marianna Rossi, Konstanze Döhner, Thorsten Zenz, Andreas Bühler, Dirk Winkler, Jennifer Edelmann, Daniel Mertens, Lars Bullinger, Sabrina Kless, Silja Mack, Sebastian Böttcher, Matthias Ritgen, Michael Kneba, Ulrich Jäger, Peter Lichter, Nancy Patten, Michael K. Wenger, Myriam Mendila, Gunter Fingerle-Rowson, Mario Cazzola, Clemens Wendtner, Anna Maria Fink, Kirsten Fischer, Michael Hallek, Hartmut Döhner
Journal: Blood (2012)
Error in Wording in: Association of
Authors: Robert Sade, David Robinson, Desmond O'neill
Journal: JAMA (2007)

To the Editor: In their Commentary, Drs Robinson and O'Neill 1 state that "to prevent erosion of the right to confidentiality after death, it is important that physicians and other health care workers strive to ensure that this confidentiality is preserved to the maximum degree possible."This is actually a familiar concept in the US medical ethics tradition.The policy of the American Medical Association (AMA) provides clear guidelines for physicians who are faced with requests to disclose medical information after a patient's death.The AMA Code of Medical Ethics 2 states that medically related confidences and information contained within a deceased patient's medical record "should be kept confidential to the greatest possible degree."This ethical standard is almost identical to that suggested by Robinson and O'Neill.In addition, the AMA ethical opinion 2 suggests that confidentiality of medical information postmortem receive the same protection as information would receive in life.Medical information during life is granted a great amount of protection, subject only to legal requirements to disclose and situations that justify disclosure due to overriding considerations (and even then, only minimal information may be disclosed). 3The ethical opinion also provides factors that should be considered when a physician is deciding whether to disclose information, such as imminence of harm to identifiable individuals or the public health, potential benefits to at-risk persons or the public health, and the impact the disclosure would have on the deceased patient.When discussing ethical issues, professional guidelines provide advice and guidance to resolve common problems faced by physicians.Although laws may not resolve the question of whether disclosure of medical information postmortem is permissible, ethical obligations do provide one answer.
Allergy and Immunology
Authors: Richard D. deShazo
Journal: JAMA (1985)

Although the mechanisms of asthma, a disease that affects 6 million Americans, are unclear, recent observations demonstrating the major role played by immunologic mechanisms and inflammatory cells and their products in the pathogenesis and perpetuation of asthma represent major A developments in the field of allergy. Airway diameter appears to be regulated in part by the autonomic nervous system through a carefully controlled balance between cholinergic and α-adrenergic bronchoconstrictor and β<sub>2</sub>-adrenergic bronchodilator effects. Bronchial smooth-muscle tone and mast cell—mediator release are known to be regulated in part by neurochemical stimulation of these cell receptors. Thus, the finding that autonomic receptor abnormalities, including increased sensitivity to α-adrenergic and cholinergic stimuli and insensitivity to β2-agonists, are common in patients with allergic diseases in general, and asthma in particular, is of special interest.<sup>1</sup>In this regard, it has recently been shown that a subset of as much as 5% of
Asteatosis and pruritus of the ear
Authors: J. C. Reynolds
Journal: JAMA (1983)

<h3>In Reply.—</h3> Soller and Stander, on the basis of an unpublished analysis of our data, raise the issue of two potential biases: protopathic and product confusion bias. The existence of protopathic bias, or bias caused by the disease preceding the risk factor, depends on how the onset of RS is defined. We defined the onset of RS as the first day of severe vomiting. In the second year of our study, aspirin was classified as a positive exposure for cases only if ingested before the first day of severe vomiting. Thus, this bias regarding the temporal association of aspirin and RS should not be a problem if the onset of vomiting properly identifies the onset of RS. Even if clinical RS can precede severe vomiting, a retrospective determination of the exact onset on the basis of a complex of nonspecific symptoms, eg, headache, fever, or sore throat, symptoms all compatible