tbuckley/cabot-search huggingface dataset:
P130 Increase in global DNA methylation at 3 months of methotrexate use is not associated to response in early ra patients
Authors: HR Gosselt, MC de Rotte, JM Hazes, R de Jonge, SG Heil
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Introduction</h3> Methotrexate (MTX) is a first-line therapy in early Rheumatoid Arthritis (eRA). However, up to 40% of treated patients do not adequately respond to MTX. MTX interferes with the folate cycle, where it indirectly inhibits the global DNA methylation donor S-adenosylmethionine (SAM). Thus, we hypothesised that global DNA methylation changes during MTX use are associated with treatment response. <h3>Objectives</h3> To examine whether there is a change in global DNA methylation (Δ%Meth) upon MTX use and if this change is associated to MTX response (ΔDAS28) in eRA patients. <h3>Methods</h3> DNA was isolated from whole blood (n=120) and Peripheral Blood Mononuclear Cells (PBMCs, n=83) of eRA patients, before and 3 months after MTX use. Samples were collected from the Treatment in the Rotterdam Early Arthritis Cohort (tREACH), a multicenter, stratified single-blind clinical trial of eRA patients. Selected patients received triple (MTX +SSZ + HCQ) or monotherapy (MTX) combined with corticosteroids. 7 CpG sites within Long-Interspersed Nuclear Elements (LINE-1), a proxy for global DNA methylation, were quantified by Sequenom Epityper. Paired t-tests or Wilcoxon Signed Rank tests were conducted to assess a change in methylation. ΔDAS28 score over 3 months was used as a measure for response. Associations between ΔDAS28 and Δ%Meth were corrected for baseline DAS28 in a linear regression model. <h3>Results</h3> In leukocytes,%Meth did not significantly change over time. However, in PBMCs%Meth in CpG1 (ΔMeth=2.61%, p=0.008), CpG2 (ΔMeth=0.73%, p=0.039) and CpG11.12 (ΔMeth=0.56%, p=0.016) significantly increased over 3 months of MTX use after Bonferroni correction. Δ%Meth in CpG8.9 was significantly associated to the ΔDAS28 (B=0.29, p=0.039), yet this was no longer significant after Bonferroni correction. Δ%Meth was not significantly associated to ΔDAS28 in any of the other LINE1 CpG sites tested. <h3>Conclusions</h3> PBMC global DNA methylation in LINE-1 CpG sites increased upon 3 months of MTX use. However, this change in methylation is not associated to MTX response. Further research is needed to investigate the role of global DNA methylation in these patients. <h3>Disclosure of interest</h3> None declared
Bronchial Asthma — Views on Therapy
Authors: Irving W. Schiller
Journal: New England Journal of Medicine (1963)

TheophyllineUp to quite recently, orally administered theophylline or its salts have been ineffectual bronchodilators because their administration in therapeutic amounts was circumscribed. Attempts to obtain more favorable results by increasing dosage were usually followed by very disagreeable gastrointestinal effects. When administered by rectum in solution or suppository, theophylline, in my experience, was found to be absorbed erratically; its administration intravenously (as aminophylline) in "epinephrinefast" patients, though very efficacious, has limitations and obviously requires the presence of special personnel.With the development, in the past few years, of water-alcohol theophylline preparations (for example, Elixophyllin and Quibron Elixir) much of the . . .
Studies from the Rockefeller Institute for Medical Research.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cardiovascular disease
Authors: J. M. Gore
Journal: JAMA (1990)

The results of multiple clinical trials performed during the 1980s make it clear in 1990 that thrombolytic therapy should be considered for all patients with evolving myocardial infarction. The major trials that have been completed or that are in progress include the following: the Thrombolysis in Myocardial Infarction (TIMI) Trial Phase I published in 1985<sup>1</sup>found that tissue plasminogen activator (TPA) was superior to streptokinase in dissolving coronary artery thrombi. The AIMS study<sup>2</sup>reported that the recently Food and Drug Administration—approved thrombolytic agent anisoylated streptokinase plasminogen activator complex can be given as a bolus with reperfusion results similar to those achieved with streptokinase. The TIMI Trial Phase II A published in November 1988<sup>3</sup>showed that, contrary to prevailing views, there was no advantage to performing angioplasty immediately after thrombolytic therapy over performing the procedure 18 to 24 hours later. The Second International Study of Infarct Survival<sup>4</sup>
Commentarie de travail de S. I. Jang et al, pp.825
Journal: Endoscopy (2012)

See also: Porcine feasibility and safety study of a new paclitaxel-eluting biliary stent with a Pluronic-containing membraneEndoscopy 2012; 44(09): 825-831DOI: 10.1055/s-0032-1309881
Effects of Medicaid eligibility expansion on prenatal care and pregnancy outcome in Tennessee
Authors: J. M. Piper
Journal: JAMA (1990)

To investigate the effects of a 1985 Tennessee Medicaid regulatory change that expanded eligibility coverage specifically for married women during pregnancy, we studied vital statistics files linked to Medicaid enrollment files. The greatest Medicaid coverage increase in terms of an absolute difference in rates and the number of women covered occurred in white married women younger than 25 years with less than 12 years of education, where enrollment increased 18% However, in that group of mothers, as well as for the total of all mothers studied, there were no concomitant improvements in use of early prenatal care, birth weight, or neonatal mortality. Analysis of the timing of enrollment relative to the beginning of pregnancy showed that more than two thirds of the women who enrolled did so after the first trimester. (<i>JAMA</i>. 1990;264:2219-2223)
European Scientific Conference on Applied Infectious Disease Epidemiology (ESCAIDE) 2012 – call for abstracts closes 13 July
Authors: None Eurosurveillance editorial team
Journal: Eurosurveillance (2012)

Preview this article: European Scientific Conference on Applied Infectious Disease Epidemiology (ESCAIDE) 2012 – call for abstracts closes 13 July, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/17/28/art20218-en-1.gif
Lenalidomide in Combination with Melphalan and Dexamethasone in Patients with Newly-Diagnosed Light-Chain (AL)-Amyloidosis: a Multicenter Phase I/II Dose Escalation Study.
Authors: Philippe Moreau, Arnaud Jaccard, Lotfi Benboubker, Bruno Royer, Xavier Leleu, Franck Bridoux, Gilles Salles, Veronique Leblond, Murielle Roussel, May Alakl, Olivier Hermine, Jean-Luc Harousseau, Jean-Paul Fermand
Journal: Blood (2009)
Radionuclide cerebral imaging confirming brain death
Authors: J. A. Schwartz
Journal: JAMA (1983)

Cerebral blood flow (CBF) was measured by portable radionuclide cerebral imaging (RCI) and by four-vessel cerebral contrast arteriography in 15 clinically brain-dead patients, including six children. Neither technique showed evidence of CBF, although four RCI scans showed sagittal sinus activity. Portable scanning techniques are therefore considered valid determinants of brain death and may be useful in lieu of contrast cerebral arteriography. (<i>JAMA</i>1983;249:246-247)
Pneumocystis Pneumonia
Authors: ERIC P. NEIBART
Journal: Annals of Internal Medicine (1988)

Letters and Corrections1 March 1988Pneumocystis PneumoniaERIC P. NEIBART, M.D.ERIC P. NEIBART, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-108-3-489_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Conte and associates (1) report their results with reduced-dose intravenous pentamidine and inhaled pentamidine as therapy forPneumocystis cariniipneumonia in patients with the acquired immunodeficiency syndrome. Several questions, however, are raised by their presentation. Clinical and objective criteria for failure, and progression of success are not clearly defined. The authors state four patients had repeat bronchoscopy and persistent organisms were seen. Were these the patients that had relapses? The authors state that 90% of evaluable patients had a satisfactory response to inhaled pentamidine. This statement appears to be questionable if three patients had progression of disease...References1. CONTEHOLLANDERGOLDEN JHJ. Inhaled or reduced-dose intravenous pentamidine for Pneumocystis carinii pneumonia. Ann Intern Med. 1987;107:495-8. LinkGoogle Scholar2. GORDINSIMONWOFSYMILLS FGCJ. Adverse reactions to trimetheprim-sulfamethozaxale in patients with the acquired immunodeficiency syndrome. Ann Intern Med. 1984;100:495-9. LinkGoogle Scholar3. KOVACSHIEMENZMACHER JMA. Pneumocystis carinii pneumonia: a comparison between patients with the acquired immunodeficiency syndrome and patients with other immunodeficiencies. Ann Intern Med. 1984;100:663-71. LinkGoogle Scholar1. LEOUNGMILLSHOPEWELLHUGHESWOFSY GJPWC. Dapsonetrimethoprim for Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome. Ann Intern Med. 1986;105:45-8. LinkGoogle Scholar2. WHARTONCOLEMANWOFSY JDC. Trimethoprim-sulfamethoxazole or pentamidine for Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome: a prospective randomized. Ann Intern Med. 1986;105:37-44. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1988Volume 108, Issue 3Page: 489-490KeywordsAIDSBronchoscopyPneumocystisPneumocystis carinii pneumoniaPneumonia Issue Published: 1 March 1988 PDF downloadLoading ...
Arthirits and Rheumatism, New York
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
JAMA as an international public health journal. Transcending geographic and political boundaries
Authors: A. Flanagin
Journal: JAMA (1991)

Seventy-two years ago, physicians in Central and South America read about the latest advances in the diagnosis and treatment of yellow fever and influenza in the pages of<i>JAMA</i>—but in their own language. Until the turn of the century, these physicians had sought information and education in the medical literature of France and Germany.<sup>1</sup>However,<i>JAMA</i>'s entry into the international publishing arena, reflecting the rise of early 20th-century US medicine, gave these physicians another reason to look north for new medical information. The<i>Edición en Español</i>, first published on January 1, 1919, looked much like a regular issue of<i>JAMA</i>.<sup>2</sup>The first issue featured 11 articles originally published in the Englishlanguage<i>JAMA</i>on such topics as blood transfusions, pasteurian methods of prophylaxis, the value of blood chemistry, and scabies in the military. In fact, four of the articles selected for inclusion in the Spanish edition were
Calcium Metabolism Studied In Patients With Malignancies
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Experimental inclusion conjunctivitis in man: measurements of infectivity and resistance
Authors: E. Jawetz
Journal: JAMA (1965)

Trachoma is a progressive, blinding eye disease endemic in many parts of the world. In 1907 Halberstaedter and Prowazek<sup>1</sup>described the typical inclusion bodies and considered their component elementary bodies to be the etiologic agent of the disease. Soon thereafter, these same investigators<sup>2</sup>and others<sup>3,4</sup>demonstrated inclusion bodies of identical microscopic appearance in cases of a self-limited nongonorrheal conjunctivitis of the newborn. The source of infection for the newborn was promptly discovered in the adult genital tract by the finding of inclusions in the female cervix and the male urethra. Initially, both the genital tract involvement and the newborn eye disease were called "genital trachoma," but subsequent observations indicated that adult eye infections with the genital tract agent (acquired in swimming pools or by experimental inoculation) invariably ran a short, self-limited course without scars or pannus formation. Thus, the concept arose that the agent of inclusion conjunctivitis,
Albumin gene expression does not correlate with colloidosmotic pressure in rats with experimental biliary cirrhosis JL Poo, A Estanes, V Maldonado, A Huberman, C P�rez, U Ribe, A Panduro. Liver Unit and Departemnt of Biochemestry. Instituto Nacional de la Nutrici�n Salvador Zubir�n, M�xico City, M�xico
Journal: Hepatology (1993)
Hyperinsulinemia rather than hyperglicemia is responsible for the exaggerated neointimal hyperplasia after experimental balloon angioplasty in diabetic rats Daniele Torella, Ciro Indolfi, Luigi Cavuto, Carmela Coppola, Giovanni Esposito, Antonio Rapacciuolo, Emilli Di Lorenzo, Cinzia Perrino, Lorena Belardo Massimo Chiariello. Federico II University, Naples, Italy
Journal: Journal of the American College of Cardiology (2001)
Marihuana
Authors: Paul H. Kuhn
Journal: JAMA (1972)

<h3>To the Editor.—</h3> Marihuana has been widely used for more than 4,000 years. Research on the effects of the drug dates back to the 19th century. Extensive investigations on its properties have been conducted in recent years by, among others, the British, Canadian, and US governments. Thus, it seems clear that if "uncertainty about the potential dangers of marihuana usage prevails among physicians and others," it is largely because these uncertain individuals do not want to accept facts that do not fit their preconceived misconceptions (or because they are too eager to accept uncorroborated reports, such as those by Drs. Kolansky and Moore [222:35,1972], the defects of which are obvious even to laymen such as myself: no control group; a subject group too small to be statistically valid; subjects who exhibited mental impairment before ever using marihuana; subjects who used other drugs in addition to marihuana, including lysergic acid diethylamide
Radiological Atlas of Bone Tumours
Authors: Howard L. Steinbach
Journal: JAMA (1974)

This long-awaited second volume includes the features that made the first volume on malignant bone tumors an outstanding publication. The initial five pages compile statistical information on the location, age distribution, and incidence of benign and malignant tumors and of other bone diseases. Benign tumors, cysts, other tumor-like lesions, and diseases of the skeleton that produce roentgenographic abnormalities suggestive of neoplasms are discussed and depicted by photographs. A few rare lesions are presented. Preceding the numerous fine illustrations in each section is a concise presentation of general information on incidence, age, sex, location, clinical features, roentgenographic, pathologic, and histologic appearance, differential diagnosis, and treatment. The information essential for diagnosis appears in as few as two to not more than five pages of text. The reversal of black with white on the photographs provides better definition of lesions but may cause some confusion, particularly for the neophyte radiologist; however, the photographs
Erratum: Promoter swapping between the genes for a novel zinc finger protein and β-catenin in pleiomorphic adenomas with t(3;8)(p21;q12) translocations
Authors: Koen Kas, Marianne L. Voz, Eva Röijer, Anna-Karin Åström, Eva Meyen, Göran Stenman, Wim J.M. Van de Yen
Journal: Nature Genetics (1997)
DEATHS IN POLICE STATIONS.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Biliary abnormalities associated with extrahepatic portal venous obstruction
Authors: M Khuroo
Journal: Hepatology (1993)

We prospectively studied 21 consecutive patients with extrahepatic portal venous obstruction for evidence of biliary tract disease. Two patients were first seen with extrahepatic cholestasis; another had recurrent cholangitis. All three patients with clinically manifest biliary disease were adults. Another five patients had icterus on clinical examination. Liver function tests revealed elevated bilirubin levels in 14 patients (66.6%), elevated alkaline phosphatase levels in 17 (80.9%) and elevated serum ALT levels in 8 (38.0%). Endoscopic retrograde cholangiography revealed abnormal findings in 17 patients (80.9%). The changes involved the common bile duct (66.6%) more often than they did the hepatic bile ducts (38.1%). Cholangiographic abnormalities included strictures (52.4%), caliber irregularity (23.8%), segmental upstream dilatation (42.8%), ectasia (9.5%), collateral veins causing extraluminal bile duct impressions (14.3%), displacement of ducts (9.5%), angulation of ducts (4.7%) and pruning of intrahepatic ducts (9.5%). The pathogenesis of such cholangiographic abnormalities is unknown. However, possible factors in such changes include collateral veins bridging the blocked portal vein, causing bile duct impressions; fibrous scarring of porta hepatis, causing angulation of bile duct; and ischemic injury to bile duct, leading to stricture formation and caliber irregularity. Biliary disease is important in the clinical outcome of patients with extrahepatic portal venous obstruction because variceal sclerotherapy has prolonged the life expectancies of such patients. (HEPATOLOGY 1993;17:807–813.)
Reflections on Fifth
Journal: JAMA Internal Medicine (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal