tbuckley/cabot-search huggingface dataset:
Pathology
Authors: George D. Lundberg
Journal: JAMA (1981)

<h3>Quality Control in Medical Laboratories</h3> The most important recent publication in this modern field was another landmark supplement to the<i>American Journal of Clinical Pathology</i>entitled "Report on the Quality Assurance Programs of the College of American Pathologists." This is a cyclic product of the premier organization in the world that deals with human laboratory quality control. This report, however, only samples the colossal data base accumulated by the College of American Pathologists in these efforts. The supplement includes 18 articles and should be reviewed in toto by all medical laboratorians. Gilbert and Platt<sup>1</sup>reported on seven years of calcium and potassium analyses by thousands of laboratories. A remarkable improvement in both analyses was demonstrated between 1971 and 1977, with coefficients of variation decreasing from 6.5% to 4.3% and 4.1% to 2.3% for serum calcium and potassium, respectively. This improvement was attributed to widespread application of new and better
Another smoking gun linking cigarettes and heart disease
Authors: P. F. Cohn
Journal: JAMA (1989)

That cigarette smoking is harmful to the heart has long been maintained by a variety of concerned health professionals— and just as vehemently denied by the tobacco industry. This denial is made possible because the evidence linking cigarette smoking to ischemic heart disease is largely indirect and circumstantial, ie, smokers have a greater chance of developing and dying from coronary artery disease than do nonsmokers. This association has been confirmed by one epidemiologic survey after another, but what is lacking are smoking guns, direct connections between cigarettes and cardiac pathophysiology. In this issue ofThe Journal, Barry and colleagues<sup>1</sup>supply a smoking gun that is especially important because it relates to real-life settings rather than the experimental laboratory. The smoking gun is really a small box, the Holter monitor, previously used only to record arrhythmias and conduction disturbances but in the last several years adapted to a new use—the
Tenofovir alafenamide versus tenofovir disoproxil fumarate for the treatment of HBeAg-positive chronic hepatitis B virus infection: a randomised, double-blind, phase 3, non-inferiority trial
Authors: Henry L Y Chan, Scott Fung, Wai Kay Seto, Wan-Long Chuang, Chi-Yi Chen, Hyung Joon Kim, Aric Josun Hui, Harry L A Janssen, Abhijit Chowdhury, Tak Yin Owen Tsang, Rajiv Mehta, Edward Gane, John F Flaherty, Benedetta Massetto, Anuj Gaggar, Kathryn M Kitrinos, Lanjia Lin, G Mani Subramanian, John G McHutchison, Young-Suk Lim, Subrat K Acharya, Kosh Agarwal
Journal: The Lancet. Gastroenterology & hepatology (2016)
Medical Genetics
Authors: Edward R. B. McCabe
Journal: JAMA (1996)

Three areas of genetics that remain active include gene identification, disease susceptibility, and gene therapy. Examples of the power of the genetic approach to identify genes without prior knowledge of the function of the gene products are the genes for ataxiatelangiectasia (AT), the infantile subtype of neuronal ceroid lipofuscinosis (NCL), and autosomal dominant polycystic kidney disease. Knowledge of the roles of specific gene products in fundamental developmental biological processes of model organisms also has permitted the identification of mutant genes in human disorders and improved the understanding of syndromic birth defects. Examples of mutant genes that predispose to cancer, in addition to the<i>AT</i>gene, are the breast cancer genes,<i>BRCA1</i>, and the newly cloned<i>BRCA2</i>gene, which are responsible for many of the familial breast cancers. Finally, gene therapy remains an area of great, but unfulfilled, promise, leading to expressions of concern about gene therapy from 2 panels sponsored
American Journal of Surgery, New York
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Alzheimer Disease, Apolipoprotein E, and Apolipoprotein(a)
Journal: Annals of Internal Medicine (2000)

Summaries for Patients4 April 2000Alzheimer Disease, Apolipoprotein E, and Apolipoprotein(a)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-7-200004040-00038 SectionsAboutFull Text ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Alzheimer disease is a medical condition in which abnormal substances build up in the brain, causing brain cells to gradually degenerate. As the brain tissue shrinks, patients experience a loss of mental abilities known as dementia. Apolipoproteins help transport fatty substances, or lipids, in the blood. Apolipoproteins and lipids form large particles called lipoproteins. There are several types of apolipoproteins. One particular apolipoprotein, apolipoprotein E (apoE) is thought to have something to do with Alzheimer disease. That is, people who carry a gene for a certain form of ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Interactions between Apolipoprotein E and Apolipoprotein(a) in Patients with Late-Onset Alzheimer Disease.”. It is in the 4 April 2000 issue of Annals of Internal Medicine (volume 132, pages 533-537). The authors are V. Mooser, N. Helbecque, J. Miklossy, S.M. Marcovina, P. Nicod, and P. Amouyel.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoInteractions between Apolipoprotein E and Apolipoprotein(a) in Patients with Late-Onset Alzheimer Disease Vincent Mooser , Nicole Helbecque , Judit Miklossy , Santica M. Marcovina , Pascal Nicod , and Philippe Amouyel Metrics 4 April 2000Volume 132, Issue 7Page: 533KeywordsAlzheimer diseaseApolipoproteinsBloodBrainGeographic areasLipidsLipoproteinsMedical conditionsNursing homesPopulation statistics Issue Published: 4 April 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.Loading ...
The Crab
Authors: Susan Beck
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
European Association for the Study of the Liver
Authors: S Erlinger, M Dumont, W Horak, G Grabner, G Paumgartner, J Nielsen, P Dietrichson, P Elling
Journal: Gut (1971)

Recent experimental reports support the hypothesis that a large fraction of hepatocytic bile is not dependent on bile salt excretion.However, the mechanism of elaboration of this fraction is not established.Suppression of this bile salt-independent flow in the rabbit by inhibitors of sodium transport suggests that it may be the result of active sodium transport by the hepatocytes.These studies were undertaken to examine the influence on bile forma- tion in the dog of theophylline, an agent known to stimulate sodium transport.In ten anaesthetized dogs, the bile duct was cannulated, a bile salt infusion (6 gmoles/min) wasgiven to obtain a stable bile flow. (1)Theophylline (280 j,umoles followed by a constant infusion of 20 ,moles/min) produced a significant increase in
Response: Labeling and LHAMA
Authors: Monona Rossol
Journal: Environmental Health Perspectives (1997)

sumers/users to comply with the supplied information.Safety assessment and risk communication is a dynamic process.Our knowledge base is constantly increasing, and society's interpretation ofwhat constitutes safety is an evolving process.As newer technology becomes available to better qualify and quantify the potential adverse effects of materials, safe and acceptable conditions for use become available and affordable for artists, whether their studios are located at homes, schools, or workplaces.Further, as toxicologists who certify compliance with LHAMA, we must reassess and recertify each unchanged art material every five years.Any changes that may have occurred in the product formulation or the state of knowledge since the initial certification are revisit- ed.In this way, new information and concerns for safety are added to our knowledge base and to the label.
Isotope demonstration of CSF pathways. Guide to antifungal therapy in coccidioidal meningitis
Authors: D. C. McCullough
Journal: JAMA (1969)

Obstruction of the outlets of the fourth ventricle and high spinal subarachnoid block developed in a patient with<i>Coccidioides immitis</i>meningitis. Radioisotope visualization procedures demonstrated absence of communication between basal meningeal areas, cerebral ventricles, and spinal theca. Drugs instilled in the crebrospinal fluid could not be effectively delivered to the basal meninges because of the two blocks. Isotope ventriculography and cisternography may be particularly useful in evaluating routes of drug administration in chronic fungal meningitis.
The risk and cost of coronary angiography. I. Cost of coronary angiography in Washington State
Authors: C. E. Hansing
Journal: JAMA (1979)

The National Guidelines for Health Planning require 300 cardiac studies per year in cardiac catheterization laboratories for adequate economic use and safety. To study how these guidelines would affect existing laboratories, data were collected on the cost of coronary angiography and use of all cardiac catheterization laboratories in Washington. The average cost of coronary angiography was $1,363, with the total cost affected by the duration of hospital stay, cardiac laboratory charges, and professional fees. Total angiographic use ranged from 293 to 791 studies per room, but eight laboratories did not perform 300 cardiac studies during 1977. Health planners recommend high use rates based on the theory that there is an inverse correlation between the number of studies and cost. In this study, the regression equation showed no fall in charges with increased number of studies. Therefore, while it may be reasonable from an economic point of view to expect 300 angiographic cases per year in existing laboratories, there is no economic justification for requiring a certain number of cardiac studies per year. (<i>JAMA</i>242:731-734, 1979)
Compounded Errors
Authors: Joseph Berkson
Journal: JAMA (1967)

<h3>To the Editor:—</h3> My attention has been called to a letter from Susan J. Standfast, MD,<sup>1</sup>which, commenting on an article by Dr. Philip Rubin,<sup>2</sup>says: He has made an error in interpretation of Fig 1. By referring back to Dr. Rubin's source, one discovers that he has borrowed Berkson's poorly labelled graph without the benefit of the statistician's accompanying text which clarifies and correctly describes the figure. I am grateful to Dr. Standfast for absolving me from responsibility for the error she says Dr. Rubin committed. But in looking at her Fig 1,I did not recognize any figure I had ever drawn. I did find in Dr. Rubin's article a figure reproduced from a paper by Berkson and coworkers,<sup>3</sup>but the legend (label?) differed from the original one. A reader who scrutinized the communication suggested that the legends of Dr. Standfast's Fig 1 and Fig 2
Poster session 4: Molecular diagnosis, patient selection and prognosis
Authors: E Stepanova, A Bokhjan, N Petrovichev, A Aliev, M Baryschnikov, I Hubeek, F Goemans, C Zwaan, A Loonen, K Ha ¨hlen, D Reinhardt, U Creutzig, M Heinrich, G Kaspers
Journal: Annals of Oncology (2005)
Limitatoins of surgical methods of pericardial drainage. Echocardiographic observations
Authors: P. A. Chandraratna
Journal: JAMA (1979)

To assess the efficacy of surgical methods of pericardial drainage in preventing the accumulation of pericardial effusion, we performed M-mode and cross-sectional echocardiograms in 26 patients before and one week after the creation of a pericardial window or leaving the pericardium open after cardiac surgery. A pericardial window was created in six patients (group 1) who had pericardial effusions. Group 2 consisted of 20 patients who had heart surgery. Echocardiography disclosed moderate or large pericardial effusions preoperatively in all group 1 patients but in none of the group 2 patients. Following operation, three of the group 1 patients had complete clearing of pericardial effusion, while three showed reaccumulation. In group 2, thirteen patients had either no effusion or a small effusion. Seven patients had moderate or large pericardial effusions that were located posterior to the heart; only one had an anterior pericardial effusion. Cross-sectional echocardiography showed posterior loculation of effusion in six of the seven patients. Pericardial drainage is not always effective in preventing accumulation of pericardial effusions. (<i>JAMA</i>242:1062-1063, 1979)
New protective antigen of group A streptococci
Authors: James B. Dale, Edna Y. Chiang, Shaoyou Liu, Harry S. Courtney, David L. Hasty
Journal: Journal of Clinical Investigation (1999)

It is widely believed that the surface M protein of group A streptococci is the predominant surface protein of these organisms containing opsonic epitopes. In the present study, we identified a new surface protein, distinct from M protein, that evokes protective antibodies. A type 18 M-negative mutant was found to be both resistant to phagocytosis in human blood and virulent in mice. The wild-type strain, but not the M-negative mutant, was opsonized by antisera against purified recombinant M18 protein or a synthetic peptide copying the NH2-terminus of M18. However, antisera raised against a crude pepsin extract of the M-negative mutant opsonized both strains, indicating the presence of a protective antigen in addition to type 18 M protein. This antiserum was used to identify and purify a 24-kDa protein fragment (Spa, streptococcal protective antigen) that evoked antibodies that opsonized the M18 parent and the M-negative mutant. The results of passive mouse protection tests confirmed the presence of protective epitopes within Spa. The deduced amino acid sequence of a 636-bp 5′ fragment of the spa18 gene showed no homology with sequences in GenBank. These studies reveal the presence of a new protective antigen of certain strains of group A streptococci that may prove to be an important component of vaccines to prevent streptococcal infections.
Stem cell transplantation: preventing relapse of transplant
Authors: Charles Craddock
Journal: HemaSphere (2018)

Centre for Clinical Haematology, Queen Elizabeth Hospital, Birmingham, United Kingdom This is an open access Abstract Book distributed under the Attribution-NonCommercial-NoDerivs (CCBY-NC-ND), which allows third parties to download the abstracts and share them with others as long as they credit the author and the abstract book, but they cannot change the content in any way or use them commercially. http://creativecommons.org/licenses/by-nc-nd/4.0
Bizarre and Wide QRS After Liver Transplant—Diagnosis
Journal: JAMA Internal Medicine (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Congenital Aneurysm of Aortic Root with Fistula to Left Ventricle: Case Report with Autopsy Findings
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
KERATOSIS ALBA
Authors: J. D. SMITH, JERRY E. DICKSON, JOHN M. KNOX
Journal: British Journal of Dermatology (1971)

Summary.— A hypopigmented lesion is described, which on initial inspection appears to be macular, but on closer examination and palpation is appreciated to be slightly elevated. It is oval or round in shape with a cauliflower‐like, scalloped border and cobblestone surface. Histopathologically it appears to be a variant of seborrhoeic keratosis.
The Surgery
Authors: Jane Galin
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Deficiency of cathepsin S reduces atherosclerosis in LDL receptor–deficient mice
Authors: Galina K. Sukhova, Yaou Zhang, Jie-Hong Pan, Youichiro Wada, Takashi Yamamoto, Makoto Naito, Tatsuhiko Kodama, Sotirios Tsimikas, Joseph L. Witztum, Michael L. Lu, Yasuhiko Sakara, Michael T. Chin, Peter Libby, Guo-Ping Shi
Journal: Journal of Clinical Investigation (2003)

Human atherosclerotic lesions overexpress the lysosomal cysteine protease cathepsin S (Cat S), one of the most potent mammalian elastases known. In contrast, atheromata have low levels of the endogenous Cat S inhibitor cystatin C compared with normal arteries, suggesting involvement of this protease in atherogenesis. The present study tested this hypothesis directly by crossing Cat S–deficient (CatS–/–) mice with LDL receptor–deficient (LDLR–/–) mice that develop atherosclerosis on a high-cholesterol diet. Compared with LDLR–/– mice, double-knockout mice (CatS–/–LDLR–/–) developed significantly less atherosclerosis, as indicated by plaque size (plaque area and intimal thickening) and stage of development. These mice also had markedly reduced content of intimal macrophages, lipids, smooth muscle cells, collagen, CD4+ T lymphocytes, and levels of IFN-γ. CatS–/–LDLR–/– monocytes showed impaired subendothelial basement membrane transmigration, and aortas from CatS–/–LDLR–/– mice had preserved elastic laminae. These findings establish a pivotal role for Cat S in atherogenesis.