tbuckley/cabot-search huggingface dataset:
A case of CD56+ cutaneous aleukaemic granulocytic sarcoma with myelodysplastic syndrome
Authors: Y. Murakami, S. Nagae, E. Matsuishi, K. Irie, M. Furue
Journal: British Journal of Dermatology (2000)

Journal Article A case of CD56+ cutaneous aleukaemic granulocytic sarcoma with myelodysplastic syndrome Y. Murakami, Y. Murakami Department of Dermatology, Faculty of Medicine, Kyushu University, Maidashi 3‐1‐1, Higashi‐ku, Fukuoka 812‐8582, Japan Divisions of Y.Murakami. E‐mail: murakamy@dermatol.med.kyushu‐u.ac.jp Search for other works by this author on: Oxford Academic Google Scholar S. Nagae, S. Nagae Department of Dermatology, Faculty of Medicine, Kyushu University, Maidashi 3‐1‐1, Higashi‐ku, Fukuoka 812‐8582, Japan Divisions of Search for other works by this author on: Oxford Academic Google Scholar E. Matsuishi, E. Matsuishi Internal Medicine and Search for other works by this author on: Oxford Academic Google Scholar K. Irie, K. Irie Pathology, Saga Prefectural Hospital Koseikan, 1‐12‐9 Mizugae, Saga 840‐8571, Japan Search for other works by this author on: Oxford Academic Google Scholar M. Furue M. Furue Department of Dermatology, Faculty of Medicine, Kyushu University, Maidashi 3‐1‐1, Higashi‐ku, Fukuoka 812‐8582, Japan Divisions of Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 143, Issue 3, 1 September 2000, Pages 587–590, https://doi.org/10.1111/j.1365-2133.2000.03714.x Published: 01 September 2000
Ultrasound Used For Transdural Echo-Ranging
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Resident Forum
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hereditary spherocytosis
Authors: P. Agre
Journal: JAMA (1989)

<h3>CASE PRESENTATION</h3> —Wafik El-Deiry, MD A 28-YEAR-OLD woman was referred for evaluation of an abnormal peripheral blood smear. She had been cared for 1 week earlier in the emergency department because of a sore throat, and was noted to have a mild anemia. The patient knew that she had undergone splenectomy at age 6 years but was unaware of any ongoing hematologic abnormality. Her medical records indicated that she had experienced neonatal jaundice requiring exchange transfusions, and at 6 years of age she had been evaluated for severe anemia. At that time, her peripheral blood smear showed erythrocyte morphology consistent with hereditary spherocytosis. This diagnosis was confirmed by osmotic fragility testing and she underwent splenectomy. She has subsequently been asymptomatic and has had two normal children born after uncomplicated pregnancies. Both of her parents were found to be clinically normal and had normal erythrocyte fragility, but one brother died of
Inferior vena caval and ovarian vein ligation for antepartum pulmonary thromboembolism
Authors: R. D. Sautter
Journal: JAMA (1966)

MASSIVE PULMONARY thromboembolism in the antepartal period is a rare but often fatal condition. This disease has been estimated to cause 18 deaths per 1 million pregnancies each year.<sup>1</sup>The precise etiology is obscure. Maternal mortality without treatment has been reported to vary from 15% to 60%.<sup>2,3</sup>The usual therapy consists of anticoagulation with sodium heparin or sodium warfarin.<sup>4</sup>However, when sodium warfarin is used, the fetal mortality rate (18%) is excessive. Fatal results from recurrent pulmonary thromboembolism have been reported in patients in which the anticoagulant state was maintained with sodium heparin.<sup>5,6</sup>Ligation of the inferior vena cava and ovarian veins offers near absolute protection against further and possibly fatal pulmonary embolism. This procedure was carried out in the patient in the case to be reported, with the survival of the mother and baby. <h3>Report of a Case</h3> A 27-year-old housewife was admitted to the
Steroid ulcers.
Authors: M. C. de Kaski, S. Levi, R. Rentsch, H. J. Hodgson
Journal: BMJ (1992)

for medical recognition of nursing autonomy and expertise in this field.'>In view of the medicolegal and other implications of this article, I wish to state that I and many other dermatologists consider that short term use of a Eusol dressing to clear adherent slough from an ulcer is perfectly reasonable.We object to the way in which Eusol has been effectively banned by nursing diktat without appropriate consultation and for no very good reason.
NOCTURNAL ENURESIS
Authors: Roland Fischer
Journal: JAMA (1953)

<h3>To the Editor:</h3> —In an article inThe Journal(<b>152</b>:381 [May 30] 1953), T. V. Geppert reports favorable results in treating a group of patients with chronic nocturnal enuresis. They were treated by being awakened by an automatic electric alarm immediately after the commencement of nocturnal urination. I proposed a similar type of therapy a few years ago in the<i>Swiss Medical Weekly (Schweiz. med. Wchnschr.</i><b>78</b>:361, 1948). The purpose of my procedure was the same: to condition the patients to awaken at the very moment of enuresis. Instead of an automatic electric alarm, which may disturb other persons too, a harmless but awakening electric current was used to condition the patient. This conditioning therapy allows the treatment of many children in the same room with individual conditioning stimuli.
CASES IN MIDWIFERY
Authors: T. Radford
Journal: BMJ (1856)

CAsZ vi.June 22nd, 1825, at the request of Mrs. Capper, I visted a hospital patient residin, at Knot Mill.She wa in her ninth month, and was flooding excessively when I saw her.She was faint; her countenance was very pallid; and her pulse feeble and flutterinig.During the previous six weeks she had two attacks, for which there was no obvious cause; but the hnemorrhage was compara-
Unresponsiveness of hepatic nitrogen metabolism to glucagon infusion in patients with cirrhosis: Dependence on liver cell failure
Authors: A Fabbri
Journal: Hepatology (1993)

Glucagon exerts an up-regulatory effect on hepatic nitrogen metabolism in healthy subjects, but its potential role in the presence of liver failure is uncertain. The effects of glucagon on urea synthesis and hepatic nitrogen clearance during alanine infusion were studied in five control subjects and six cirrhotic patients in paired experiments at spontaneous glucagon concentrations and at high physiological glucagon levels (≈ 300 to 500 pmol ˙ L−1) induced by a 7.5-hr continuous glucagon infusion. In all experiments the urea nitrogen synthesis rate increased linearly with increasing α-amino-nitrogen concentrations. At spontaneous glucagon concentrations the dynamics of α-amino nitrogen to urea nitrogen conversion (functional hepatic nitrogen clearance) were significantly reduced in cirrhosis (23.2 ± 6.7 L ˙ hr−1 vs. 35.3 ± 8.0 L ˙ hr−1, p < 0.05) in relation to decreased liver function. Glucagon superinfusion caused a 63% increase in the dynamics of the process in controls (57.7 ± 11.0 L ˙ hr−1; p vs. spontaneous glucagon, p < 0.01), whereas in cirrhosis it increased on average by only 15% (26.7 ± 10.7; p = NS). The glucagon-induced change in functional hepatic nitrogen clearance significantly correlated with galactose elimination capacity and antipyrine clearance (r = 0.905 and 0.964, respectively). Glucagon, in high physiological concentrations achieved with glucagon infusion, does not produce significant effects on hepatic nitrogen metabolism in cirrhosis. The reduced sensitivity of the cirrhotic liver to glucagon seems to be dependent on decreased hepatocellular function. These data do not support the role of glucagon as a “catabolic” hormone in cirrhosis. (HEPATOLOGY 1993;18:28–35).
A CASE OF ABDOMINAL PREGNANCY AT SEVENTEEN MONTHS
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Archives of Environmental Health, Chicago
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ERRATUM
Authors: Daniel Oh, Melissa Troester, John Foekens, David Atkins, Yi Zhang, Fred Sweep, Nadia Harbeck, Angelo Paradiso, Tanja Cufer, Anieta Sieuwerts, Dmitri Talantov, Paul Span, Vivianne Tjan-Heijnen, Alfredo Zito, Katja Specht, Heinz Hoefler, Rastko Golouh, Francesco Schittulli, Manfred Schmitt, Monica Spinola, Peter Meyer, Stefan Kammerer, F Falvella, Melanie Boettger, Carolyn Hoyal, Carmen Pignatiello, Reiner Fischer, Richard Roth, Ugo Pastorino, Karl Haeussinger, Toshiyuki Takeuchi, Shuta Tomida, Yasushi Yatabe, Takayuki Kosaka, Daniel Haller
Journal: Journal of Clinical Oncology (2006)

Tier 4: $1,140 US, $1,395 Int'l; Tier 5: contact JCO for a quote.
The Practice of Surgery.
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Vigorous Physical Activity Among High School Students—United States, 1990
Journal: JAMA (1992)

Vigorous physical activity can improve the health of both adults and children. Among adults, regular physical activity can reduce risk for chronic diseases such as coronary heart disease, hypertension, noninsulin-dependent diabetes mellitus, colon cancer, and depression, as well as lower all-cause death rates (1,2). Among children, regular physical activity can reduce chronic disease risk factors such as obesity, elevated cholesterol, and hypertension (3). Physical activity patterns established during childhood may extend into adulthood (4). This report examines the prevalence of vigorous physical activity among U.S. students in grades 9-12.
Preschool screening for cryptorchidism.
Authors: S. A. Kaul, D. P. Roberts
Journal: BMJ (1992)

death reported by Lim2 is unlikely to have been due to flumazenil,4 while the mechanism of action in the death reported by Burr et al was a withdrawal of the protective action of benzodiazepines in a patient who had taken a multiple drug overdose.3The same mechanism also explains the precipitation of ventricular arrhythmias in the report that Katz and colleagues quote in support of their own case.5Benzodiazepines have a dampening effect on sympathetic nervous system activity,6 and animal studies suggest that they can increase the electrical stability of the heart in patients with acute myo- cardial infarction.7There is little doubt that sympathetic activity in restless, waking, intubated patients is increased.This is primarily the result of irritation due to the endotracheal tube, a response that is augmented in the presence of hypoxia or pain, or both.In this setting reversing sedation with flumazenil unmasks increased sympathetic drive and cardiac electrical instability, thereby precipitating ventricular arrhythmias in an already severely damaged myocardium with compromised left ventricular function.The conclusion can be only that the fatal drug actions in this case are similar to those reported elsewhere.35There is no evidence for any direct cardiac effect of flumazenil.
Intrathoracic hibernoma.
Authors: A D Morgan, E M Jepson, J D Billimoria
Journal: Thorax (1966)

Benign tumours morphologically resembling the brown fat of the human embryo or infant and the interscapular gland of hibernating animals were first recognized 60 years ago.The term 'hibernoma', as applied to a human neoplasm, may be objectionable, but it has become justified by usage.In human embryos brown fat is found in the interscapular region, neck, and axillae; in the mediastinum and below the parietal pleura; in the omental, periadrenal, and perinephric fat; in the groins and, as detached foci, in the peripheral parts of the limbs (Shaw, 1901 ; Rasmussen, 1923; Aherne and Hull, 1964).Microscopically it con- sists of lobules of round cells about half the size of fat cells, with a granular or foamy cytoplasm and a small round centrally placed nucleus (Fig. 1).The brown colour is apparently due to a high concentration of cytochromes (Joel and Ball, 1960).;eN.-S,< t .v
Emergency cardiac care. The science behind the art
Authors: J. A. Paraskos
Journal: JAMA (1992)

At the very birth of medicine as a rational endeavor, the centrality of the scientific method was firmly established. In the Hippocratic writings, we are told of the conditions necessary for the proper conduct of medicine: "There are in fact two things, science and opinion; the former begets knowledge, the latter ignorance."<sup>1</sup>The art (the<i>technē</i>) of medicine is characterized in the same passage as the use made of that knowledge in the light of accumulated clinical experience, so that "rashness indicates want of art." In harmony with these concepts and underscoring their importance, the 1992 National Conference on Cardiopulmonary Resuscitation (CPR) and Emergency Cardiac Care (ECC) grades its recommendations according to the merit of the scientific evidence that led to them. Rules of evidence were delineated by the ECC Committee of the American Heart Association (AHA) that were used to evaluate the merit of the scientific data.<sup>2(p2174)</sup>
Abstract 376: Therapeutic role of <i>ESR1</i>-<i>CCDC170</i> gene fusion in breast cancer endocrine resistance
Authors: Li Li, Jamunarani Veeraraghavan, Yiheng Hu, Xian Wang, Ying Tan, Rachel Schiff, Xiaosong Wang
Journal: Cancer Research (2019)

Abstract Background: Gene fusions resulting from genomic rearrangements are important drivers for cancer initiation and progression. Estrogen receptor-positive (ER+) breast cancer is the most common type of breast cancer, and luminal B confers a more aggressive phenotype and higher risk of early relapse and prone to resistance to endocrine therapy. Identify new druggable genetic driver will be critical to improve clinical outcome of aggressive luminal B tumors. Our lab has identified a recurrent rearrangement between the estrogen receptor gene ESR1 and its neighbor gene CCDC170, in 6-8% of luminal B tumors. The exon 2 of ESR1 fused with the exon 6, 7, 8 or 10 of CCDC170, which enables the expression of different-sized N-terminally truncated CCDC170 (ΔCCDC170) under ESR1 promoter. Ectopic expression of ΔCCDC170 led to malignant transformation phenotypes in ER+ breast cancer cells, such as increase the cell migration, invasion and anchor-independent cell growth, as well as enhance xenograft tumor growth in mice. Methods: The effect of ESR1-CCDC170 on endocrine resistance was examined by cologenic assay in vitro, and by xenograft mouse model in vivo. Bioinformatics approaches, Reverse Phase Protein Array (RPPA) analysis and Bimolecular Fluorescence Complementation assay were used to elucidate the potential molecular mechanism. Results: This study aimed to determine the role of ESR1-CCDC170 in breast cancer endocrine resistance and elucidate the potential mechanisms as well as the therapeutic effect thereof. Our results show that ectopic expression of fusion variants in ER+ T47D cell line sustains the cell proliferation ability under estrogen deprivation (ED), and decreases the sensitivity to 4-OH Tamoxifen treatment. While silencing of ESR1-CCDC170 in fusion positive HCC1428 cell line increases the sensitivity to 4-OHTamoxifen and Fulvestrant treatment. Results from T47D xenograft tumor models show that ESR1-CCDC170 fusion induces endocrine resistance in vivo. Further mechanism studies show that ESR1-CCDC170 possesses a potential ATP binding pocket, has the ability to form homodimers. Conclusion: These results demonstrate the important role of ESR1-CCDC170 fusions in breast cancer endocrine resistance, and suggest that ESR1-CCDC170 fusion could be a potential therapeutic target for the treatment of breast cancer. Citation Format: Li Li, Jamunarani Veeraraghavan, Yiheng Hu, Xian Wang, Ying Tan, Rachel Schiff, Xiaosong Wang. Therapeutic role of ESR1-CCDC170 gene fusion in breast cancer endocrine resistance [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 376.
Treatment of hyperparathyroidism with etidronate disodium
Authors: A. A. Licata
Journal: JAMA (1983)

THE DIPHOSPHONATES are synthetic inhibitors of skeletal resorption that have been used expermentally to treat hyperparathyroidism.<sup>1-3</sup>Much evidence has accumulated about the beneficial effect of the different forms of this class of drugs in normalizing the biochemical abnormalities of the disease, but there are few data about the clinical response of patients. This report describes an elderly woman with hyperparathyroidism who was treated with the commercially available form of the drug, etidronate disodium (Didronel). It shows the clinical and biochemical response during treatment with small doses of the drug. <h3>Report of a Case</h3> A 75-year-old woman was referred to the Endocrine Clinic for skeletal pain caused by primary hyperparathyroidism. She had associated problems of congestive heart failure, angina, and hypertension, which precluded surgical treatment. For several years, she had proximal weakness of the forearms, increased fatigue, forgetfulness, constipation, and hemorrhoids. For one year she noted severe pains in the
Cor Leopardum
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal