tbuckley/cabot-search huggingface dataset:
Gerontology researchers sharpen focus but face more complex challenges as 21st century looms
Authors: P. Gunby
Journal: JAMA (1995)

FUTURE LONGITUDINAL studies of aging will examine, among other factors, how the process of growing older reduces independent functioning and increases vulnerability to morbidity and mortality, plus what can be done about this and when to do it. That is the prediction of James L. Fozard, PhD, and some colleagues in Baltimore, Md, at the Gerontology Research Center (GRC), National Institute on Aging (NIA), where the Baltimore Longitudinal Study of Aging (BLSA) has been under way since 1958 (<i>JAMA</i>. 1967;201:32). Fozard, who is the NIA's associate scientific director for the BLSA, says it is important to study prospectively the often subtle age-related changes in the underlying mechanisms of human functioning. That is, many gerontology researchers are saying, it is important to understand those factors associated with aging that lead to the increasing susceptibility to disease and loss of functional ability. <h3>Cost of 'Growing Up'</h3> The underlying mechanisms begin to exert
Radium in Gynecology.
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
癌症患者中的大疱性类天疱疮风险
Authors: C.T. Chen, H.Y. Hu, Y.T. Chang, C.P. Li, C.Y. Wu
Journal: British Journal of Dermatology (2019)

大疱性类天疱疮 (BP) 是一种导致皮疹和皮肤瘙痒性水泡的皮肤病。它是由于人体对自身皮肤产生了抗体 ‐ 即所谓的自身免疫性导致的。疾病发作可导致极度不适,需要来自皮肤科医生和他们家人的努力来照料患者。确诊患有 BP 的人群通常已经患有其他疾病,例如糖尿病、神经系统疾病(包括帕金森病和阿尔茨海默病)和心血管疾病,这些是 BP 的已知风险因素。但是,癌症和 BP 的关系仍有争议。这项来自中国台湾的研究旨在探讨癌症患者之后发生 BP 的风险是否增高。此外,计划探索哪些类型癌症可能有最强的相关性。作者们使用中国台湾健康数据库(包括 100 万随机采样的受益人)进行了这一研究。共选择了 36,838 名癌症患者和 147,352 名非癌症患者(后者作为对照组)。为计算发病率(广泛意义上某疾病出现新病例的比率),科学家按“人年”计算了发病率,期间将该研究中的人数、每个人参与研究的总时间、研究期间出现该疾病的人数等多方面因素考虑在内。使用这一方法,在 2002 和 2011 年间,癌症患者中有 22 人发生 BP(17.2 例/10 万人年),对照组中有 171 人 (19.8 例/10 万人年)。癌症患者中的 BP 发生率并不高于对照。发现年龄、糖尿病和脑血管疾病是 BP 的风险因素。这项研究还发现,脑和其他神经系统癌症患者之后 BP 的发生率(128.3 例/10 万人年)相对高于其他类型癌症的患者。这项研究的结果提供了癌症不是 BP 风险因素的确凿证据。
BOSTON LETTER.
Authors: G. R. Henry
Journal: JAMA (1883)

Burlington, Iowa, July 23, 1883. <h3>Dear Doctor.</h3> —I have received your first number, and am delighted with it as a journal; but I am not so pleased with your advertisements. Parke, Davis &amp; Co. have bored the physicians of the Northwest sufficiently with their ready-made prescriptions. In fact, they have taken the place of Ayer's Pectoral and Humbold's Buchu, and are patronized by all the quacks and all the patent medicine men in this country. Soon I presume you will advertise Warner's safe cure for kidney trouble. Now, I protest right here against the organ of the American Medical Association being the means of disseminating any such advertisements. I ask a place for this in your correspondent's column, and see if I am not indorsed by nine-tenths of the physicians in the land. Yours truly,
ChIP sequencing of cyclin D1 reveals a transcriptional role in chromosomal instability in mice
Authors: Mathew C. Casimiro, Marco Crosariol, Emanuele Loro, Adam Ertel, Zuoren Yu, William Dampier, Elizabeth A. Saria, Alex Papanikolaou, Timothy J. Stanek, Zhiping Li, Chenguang Wang, Paolo Fortina, Sankar Addya, Aydin Tozeren, Erik S. Knudsen, Andrew Arnold, Richard G. Pestell
Journal: Journal of Clinical Investigation (2013)

During the processing of this manuscript, the Western blot in Figure 3D
News and Notices
Authors: P Agrawal, R George, M Thomas, E S C H M I, M Leverkus, S Galli, G Nilsson, F Levi, U Blank, W Weninger, M Au
Journal: British Journal of Dermatology (2015)

most ASBDs reported to date demonstrate autoantibodies of the IgG4 subclass. 12The blister-inducing capacity of autoantibody subclasses in ASBD has been examined, and provides mechanistic insight into disease pathogenesis.In our patient, the steroid resistance and the rapid and remarkable response to colchicine were noteworthy.Interestingly, the only ASBD with good clinical responses to (adjuvant) colchicine is EBA. 5 This supports the suggestion that the present case may be best classified as an unusual form of childhood EBA.As scarring and milia are disfiguring, early intervention with colchicine, as successfully demonstrated in our case, is advisable.Our case highlights the need for further careful study of such rare ASBDs in childhood.
Estimating incidence of stroke using capture-recapture models
Authors: Kate Tilling, Jonathan AC Sterne, Charles DA Wolfe
Journal: Circulation (2001)

P57 Background:Incidence of stroke (and other cardiovascular diseases) is often estimated using population-based registers. No register is 100% complete, and cases missed may differ from those registered, for example by having less severe disease. Failure to estimate the number of cases missed will lead to under-estimation of the true incidence of disease. Comparisons between areas, or examination of trends over time, will also be biased if the probability of being registered varies between them. Methods: Recently developed capture-recapture models including covariates were used to estimate incidence of stroke using data from a population-based register in South London, UK. The model parameters were used to estimate ascertainment-adjusted age-standardised incidence rates. Confidence intervals which allow for the uncertainty in the estimation of population size were calculated. Results:The crude capture-recapture model (not including covariates) under-estimated the number of non-fatal strokes. Probability of capture by the register was associated with both demographic variables and stroke-severity indicators. A capture-recapture model including these covariates led to more plausible estimates of the numbers of both fatal and non-fatal strokes, and suggested that the stroke register was approximately 88% complete. Adjusting for the number of cases missed increased the estimated incidence from 1.31 (95% confidence interval 1.21 to 1.42)to 1.49 (95% confidence interval 0.38 to 2.60) per 1,000 people. Conclusions: Using these methods, data from an incomplete register can be used to calculate both incidence and age-standardised incidence. However, sparse data in subgroups can lead to wide confidence intervals for adjusted rates. Routine registers might be made more cost-effective by using the combination of sources and covariates which most accurately estimates the population size, instead of aiming for 100% completeness. Comparisons of incidence between registers should be based on rates which are adjusted for the number and type of cases missed.
The Epidemiology and Control of Open Angle Glaucoma: A Population- Based Perspective
Authors: J. M. Tielsch
Journal: Annual Review of Public Health (1996)

Chronic open angle glaucoma is an etiologically heterogeneous group of diseases characterized by damage to the optic nerve, resulting in peripheral visual loss that can progress to involve the fovea and central vision. Open angle glaucoma can be divided into primary conditions and conditions which are secondary to another ocular or systemic disease. Causes of secondary glaucoma include uveitis, cataract, trauma, and disorders affecting the development structure of the angle. This review focuses on primary open angle glaucoma (POAG), since it accounts for the vast majority of the disease burden in the US population and its etiology remains unknown.
Identification of the activated form of the progesterone receptor (PR) in breast cancer (BC).
Authors: Jacques Bosq, Jean-Michel Caillaud, Carol A. Lange, Suzanne A. W. Fuqua, Joyce O'Shaughnessy, Erard M. Gilles, Alexander A. Zukiwski, Jacques Bonneterre
Journal: Journal of Clinical Oncology (2013)

593 Background: Upon ligand binding, PRs dimerize and form a discrete focal subnuclear distribution pattern (FDP), which are associated with transcriptional activation of PR (APR). FDP and are observed in BC independently of menopausal status. The feasibility of using an IHC technique to characterize the PR functional status has previously been reported in BC and presence/absence of APR is hypothesized to predict anti-progestin activity. This study describes an immunohistochemistry (IHC) method, by which a biomarker could be developed to investigate this hypothesis. Methods: 303 paraffin embedded/formalin fixed archival BC samples were processed with PR-A or PR- B isotype specific antibodies. Nuclear morphology was analyzed with standard microscopy at x1000, interpretation of the IHC slides was done by an experienced pathologist. Standard PR, estrogen receptor (ER), and Ki67 testing were done. Tumor grading/stage was obtained from the patients’ records. Results: Histology was ductal 85%, lobular 13%, other 2%. Consistent with prior research observations, tumors had two PR nuclear morphologies: 1. Diffuse pattern (D) where the PR was distributed evenly in a fine granular pattern or, 2. Aggregate pattern (A) where the PR is distributed in discrete clumps or aggregates. This defined 3 tumor phenotypes: A cells only (A), D cells only (D), and a heterogenous mix of A+D cells (AD). The APR pos group is defined as the A and A+ D phenotypes. Tumors were PR positive in 76% for PRA and 80% for PRB. Tumors were APR pos for PRA in 23% and independent of PR intensity score, ER, Ki67, and HER2, but associated with higher PR % positivity and higher tumor grade. Tumors were APR pos for PRB in 22% and associated with lower PR intensity and higher tumor grade, independent of ER pos %, PR pos %, Ki67 and HER2. Conclusions: PR positive BC tumors can be grouped in two categories based on PR nuclear morphology: 1. a group with diffuse and homogenous nuclear staining, 2. a group with heterogeneous area of cells having a nuclear pattern consistent with a functional or activated PR (APR). The described IHC technique to identify APR has the potential to be developed as companion diagnostic as a potential predictor of anti-progestin efficacy in patients with BC.
First Report of the Clinic for the Treatment of Communicable Pulmonary Diseases. Department of Health, City of New York.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Third Great Plague. A Discussion of Syphilis for Everyday People.
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tampons and Toxic Shock Syndrome
Authors: M. T. Osterholm
Journal: JAMA (1983)

<h3>To the Editor.—</h3> The recent article inThe Journal(1982;247:835) by the Centers for Disease Control (CDC), Atlanta, regarding their second toxic shock syndrome (TSS) case-control study also discussed the results of our Tri-State Toxic Shock Syndrome Study (TSTSSS).<sup>1</sup>We believe some of their study findings and ours have been misinterpreted in the CDC article. In the CDC report, emphasis was placed on the finding of the association of menstrually related TSS with the use of Rely brand tampons and the lack of difference found between cases and controls in the absorbency of the tampon product used. The discussion regarding the lack of a relationship between absorbency and the risk of TSS developing is incomplete and misleading. First, every tampon brand has two to five different brand styles (regular, super, and super plus) that have different absorbency levels. In September 1980, all five major tampon brands included brand styles
Surgical treatment of morbid obesity
Authors: J. A. Buckwalter
Journal: JAMA (1979)

<h3>To the Editor.—</h3> Overt bleeding is rarely the presenting manifestation of gastric malignant neoplasm. Most reported series of cases of carcinoma that does not extend beneath the submucosa do not mention clinically evident hemorrhage as a feature. Early gastric carcinoma is uncommonly diagnosed in the United States but has a favorable prognosis. The following is a report of superficial gastric carcinoma with bleeding. <h3>Report of a Case.—</h3> A previously healthy 58-year-old woman was hospitalized with melena. Findings from physical examination were normal. Endoscopic examination showed a focal, indeterminate, gastric mucosal abnormality with an adherent blood clot and active bleeding. Her hemoglobin level decreased to 9.0 g/dL, but the bleeding stopped. A few days later, the endoscopic examination was repeated. An area of mucosa in the anterior corpus, approximately 2 cm in diameter, appeared slightly mammillated and had delicate submucosal hemorrhages surrounding a small stellate erosion. The remainder of the stomach
The Ciliary Transportability of Sputum is Slow on the Mucus-depleted Bovine Trachea
Authors: Peter J. Wills, Maria J. Garcia Suarez, Andrew Rutman, Robert Wilson, Peter J. Cole
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

Mucus retention in the lungs is a feature of several chest diseases. It is unclear to what extent suboptimal mucus transportability is responsible for the poor clearance of lung secretions. We describe a new model, the mucus-depleted bovine trachea, for measurement of the ciliary transportability of respiratory mucus. Mucus depletion was demonstrated microscopically and functionally, and it was accomplished by simple physical means without impairing ciliary action. Control mucus from the tracheas of humans and animals was transported rapidly on this system. However, sputum from 54 patients with bronchiectasis was transported slowly, at a mean of 15% of the rate of control mucus. There was no correlation between sputum transportability and either purulence or the presence of Pseudomonas aeruginosa. This work suggests that there is a serious defect in the ciliary transportability of sputum that is unrelated to the presence of infection. The model should allow in vitro assessment of agents designed to aid mucociliary clearance.
Early changes in circulating FGF19 and ANG-2 levels as a possible predictive biomarker for lenvatinib therapy in hepatocellular carcinoma
Authors: Makoto Chuma, Haruki Uojima, Kazushi Numata, Hisash Hidaka, Hidenori Toyoda, Atsushi Hiraoka, Toshifumi Tada, Shunji Hirose, Takashi Nakazawa, Masanori Atsukawa, Norio Itokawa, Taeang Arai, Manabu Morimoto, Katsuaki Ogushi, Akito Nozaki, Tatehiro Kagawa, Takashi Kumada, Shin Maeda
Journal: Journal of Hepatology (2020)
Measles Vaccine
Authors: Samuel Karelitz
Journal: JAMA (1961)

Clinical and serological observations have been made on 103 children who received an attenuated strain of live measles virus. The vaccine was prepared from the Edmonston strain of Enders, propagated in tissue cultures of chick embryo. Safety tests were carried out in rabbits, mice, and guinea pigs. Antibody responses were determined by 2 methods, one involving the cytopathogenic effect of mixtures of virus with serum, the other involving a metabolic inhibition test. In 10 children the fever and malaise were like those of mild measles; the other children carried on as usual. No secondary cases were found. Of the 88 children who had been nonimmune, the 86 who could be followed gave serological evidence of immunization similar to that following ordinary measles. Complications were rare, and the vaccine was generally accepted by parents and physicians.
Rehabilitation: an evolving concept
Authors: C. G. Eustace
Journal: JAMA (1966)

The word rehabilitation is relatively new and our present concept has attained form and subtance only recently. The idea, however, is as ancient as the practice of medicine. I shall attempt to put into a meaningful picture what we are dealing with in a vocational rehabilitation center. The things I have to say may perform as aids to memory and as challenges to more effective operation, the modest duties of a sketchbook. It is sometimes possible to catch something of the recovery of the past and the delineation of the present, in the swift movement of a lightly penciled sketch. And, if I may be permitted to mix metaphors, I must confess that "I have gathered a posie of other men's flowers/And nothing but the thread that binds them is mine own." I suppose the first recorded case of rehabilitation is to be found in the book of Genesis, with
New demands for medical manpower
Authors: P. R. Lee
Journal: JAMA (1966)

The crisis in American medicine certainly has been diagnosed and treated in a hundred different ways in the last ten years. There is increasing concern that the eye of the storm is health manpower. In a recent series of articles in the<i>Los Angeles Times</i>, the outstanding<i>Times</i>reporter, Harry Nelson, noted as follows: Now that we have Medicare, and other far more revolutionary medical programs are on the horizon, where are we going to get all of the doctors to provide the services? The answer is, that the United States will not have enough doctors for a long, long time, if ever. An affluent society that is becoming increasingly health conscious is making greater demands than the medical and auxiliary health professions can supply. In a few words, Mr. Nelson summarized what I am presenting in more detail. We have a variety of factors influencing the rising tide of
CORRECTION
Journal: Circulation (1953)

In the paper entitled "Intramural Depolarization Potentials in Myocardial Infarction: A Preliminary Report," by Prinzmetal, Kennamer, Shaw, Kimura, Lindgren and Goldman, published in the January 1953 issue of CIRCULATION, one statement requires correction. In the next to last sentence of the foreword, it is stated: "In the normal ventricle, positive depolarization potentials greatly predominate over negative potentials." This sentence should read: "In the normal ventricle, negative depolarization potentials greatly predominate over positive potentials."
Therapeutic Use of Albumin: 2
Authors: Michael R. Alexander
Journal: JAMA (1982)

It has previously been shown that albumin costs in a Veterans Administration Hospital constituted a large portion of the pharmacy drug budget and that much albumin was prescribed inappropriately. Therefore, a program of education and use monitoring was instituted to improve understanding and prescribing of this product. Inappropriate use declined from 41% to 26% of total albumin units and, more dramatically, total cost of albumin used had decreased by 90% one year after this program was initiated. Projected yearly savings from decreased use was more than $85,000. These results demonstrate that such a program can promote more appropriate use of albumin and effect a cost savings for hospitals. (<i>JAMA</i>1982;247:831-833)
CITY WATER WORKS
Journal: JAMA (1960)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal