tbuckley/cabot-search huggingface dataset:
Vaccine-acquired paralytic poliomyelitis in an unvaccinated mother
Authors: L. J. Morse
Journal: JAMA (1966)

LIVE oral poliovirus vaccine is responsible for the almost complete elimination of paralytic polio-myelitis.<sup>1,2</sup>Henderson et al's<sup>1</sup>data reveal the risk of paralytic poliomyelitis from live oral vaccine to vary according to the vaccine type and age of the recipient. The rate for type I vaccine is 0.17 per million doses administered; for type II, 0.02; and for type III, 0.4. In the older age group, especially for type III vaccine, the rate is 0.64 per million doses given. Dissemination of poliovirus occurs in close contacts following exposure to a recent vaccine recipient; however, cases of paralytic poliomyelitis acquired in such a manner have been exceedingly rare.
THE USE OF MERCUROCHROME IN PATHOLOGIC AND BACTERIOLOGIC TECHNIC
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abnormal intracellular distribution of O6-alkylguanine-DNA-alkyltransferase in hepatitis B cirrhotic human liver: A potential cofactor in the development of hepatocellular carcinoma
Authors: S Lee
Journal: Hepatology (1996)

The expression of O6-alkylguanine-DNA-alkyltransferase (ATase), which is responsible for repair of the promutagenic and cytotoxic DNA lesion O6-alkylguanine, was examined by immunostaining in a series of liver sections from normal and hepatitis-B cirrhosis patients using a polyclonal anti-human ATase antiserum. In 10 normal liver sections, the ATase staining was predominantly nuclear and very intense in the majority of the hepatocytes with a panacinar distribution. In contrast, in 15 hepatitis-B sections, the ATase was located mainly in the cytoplasm of the majority of the hepatocytes and had a perinuclear distribution. Scattered hepatocytes showed a more intense staining involving all or part of their cytoplasm; nuclear staining, however, was reduced in intensity, being inconspicuous in seven and patchy and weak in eight. ATase activity in extracts of 10 of the hepatitis-B livers varied from approximately 90 to 360 fmoles/mg protein and there was no apparent relationship between these levels and the cellular distribution of the enzyme. The sequestration of the ATase protein in the cytoplasm, away from its site of action in the cell nucleus suggests that in hepatitis-B cirrhosis, the repair of O6-alkylguanine lesions by ATase may be less efficient than in normal hepatocytes. The abnormal cellular distribution of ATase may thus be an additional cofactor in the development of hepatitis-B-associated hepatocellular carcinoma.
CAPE TOWN
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Zeitschrift fur Orthopädie, Stuttgart
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Acute Renal Failure
Authors: Ravi Thadhani, Manuel Pascual, Joseph V. Bonventre
Journal: New England Journal of Medicine (1996)

Acute renal failure is characterized by a deterioration of renal function over a period of hours to days, resulting in the failure of the kidney to excrete nitrogenous waste products and to maintain fluid and electrolyte homeostasis. In the past five decades, several important causes of acute renal failure and the pathophysiologic mechanisms that underlie renal dysfunction have come to be understood. In this article we highlight the epidemiology, general causes, and evaluation of acute renal failure in adults. We then expand on the pathophysiology of ischemic acute renal failure and discuss the rationale for both current and future therapies. . . .
A phase II trial of riluzole, an antagonist of metabotropic glutamate receptor (GRM1) signaling, in advanced melanoma.
Authors: J. M. Mehnert, Y. Wen, J. H. Lee, L. Dudek, L. Pruski-Clark, W. Shih, S. Chen, J. S. Goydos
Journal: Journal of Clinical Oncology (2011)

8557 Background: Preclinical studies demonstrate that GRM1 is a potential therapeutic target in melanoma, with > 60% of human melanomas ectopically expressing GRM1. Moreover, GRM1 over-expression renders melanoma cells more sensitive to treatment with riluzole, an oral agent that blocks glutamate release. Our phase 0 trial of riluzole in patients (pts) with resectable melanoma demonstrated a 34% (4 of 12 pts) PET response to 14 days of riluzole at 100 mg bid, with responding pts demonstrating decreased levels of pERK and pAKT in post treatment tumor biopsies. To further explore the activity of riluzole in advanced melanoma, we performed a phase II trial with the primary objective of response rate. Methods: Eligibility included pts with stage III (unresectable) or IV melanoma, ECOG PS ≤ 2 who received no more than 1 prior chemotherapy regimen. 100 mg bid of riluzole was administered for 6 week cycles. Paired tumor biopsies were collected in most pts to compare levels of pERK and pAKT. The trial employed a Simon two stage minimax design to test the response rate of 5 vs. 20% at alpha=0.05 and power=80%, requiring 1 response of 13 pts in stage 1 to continue to enroll 14 additional pts in stage 2. Results: 13 pts have been enrolled in stage 1, all with GRM1 positive tumors. No RECIST responses have yet been seen in 12 of 13 pts with 1 pt awaiting restaging. Stable disease was noted at first re evaluation in 5 of 12 pts. Riluzole was well tolerated with dizziness (30%) and fatigue (30%) the most common toxicities. 1 pt was taken off study for grade 3 dizziness. 1 pt remains on study with stable disease at 34 weeks. Of 8 paired tumor samples, 6 showed a significant decrease in pERK with 3 of these also showing a significant decrease in pAKT post-treatment. These last 3 pts each experienced stable disease at first re evaluation. Testing for B-raf and N-ras mutational status is in progress. Conclusions: Riluzole was well tolerated. Although no responses were yet seen by RECIST criteria, initial stable disease was seen in 42% of previously progressing pts. While biologically active, the modest antitumor activity suggests that riluzole should be tested in combination with other anticancer agents. Funded by NIH 1R21CA139473-02.
Use of Human Lung Tissue for Studies of Structural Changes Associated with Chronic Ozone Exposure: Opportunities and Critical Issues
Authors: Morton Lippmann
Journal: Environmental Health Perspectives (1993)

Definitive information on the chronic effects of exposure to ozone (03) in humans is not available.There is a strong concern that ozone could pro- duce chronic lung damage in humans on the basis that exposures are ubiquitous at levels that produce transient symptoms, function deficits, and lung inflammation in humans and chronic lung damage in laboratory animals.Both prospective and national population surveys suggest an association between chronic 03 exposure and reduced lung function, and a pilot investigation of autopsied lungs of accident victims in Los Angeles reported an unexpectedly high incidence of disease in the centriacinar region, the lung region known to receive the highest dose of inhaled 03.This paper discusses the advantages and limitations of further studies of structural changes in human lung tissue in relation to chronic 03 exposure.The major advantages of such studies are that a) measurable effects may be related to realistic chronic exposures, b) the effects may be described quantitatively and compared directly to those obtained in chronic animal inhalation exposures, and c) evidence for chronic effects may be obtained much more rapidly than in prospective studies.The major limitations are the difficulties in obtaining sufficient reliable information on residential history, physical activity out-of-doors, and smoking and other confounding exposures to lung irritants from next of kin, and limited availability of adequate air quality data for determining ambient concentrations at places of residence and/or outdoor exercise.The paper also discusses approaches to minimizing these limitations in the design of specific studies.
Distant Healing
Authors: Ted J. Kaptchuk
Journal: Annals of Internal Medicine (2001)

Letters20 March 2001Distant HealingTed J. Kaptchuk, OMDTed J. Kaptchuk, OMDHarvard Medical School; Boston, MA 02215 (Kaptchuk)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-134-6-200103200-00025 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The thoughtful systematic review of the efficacy of “distant healing” by Astin and colleagues raises many questions (1). For me, the most interesting conundrum is not whether distant healing works (I'm highly skeptical) but how such a discussion reveals the contradiction within medicine between a rational perspective, exemplified by laboratory-based scientific knowledge, and the clinical–empirical approach currently based primarily on randomized, controlled trials (2). Will more trials of distant healing with increased methodologic rigor be helpful? If the results of such trials are negative, there is no problem: Rational and empirical knowledge agree. If the results of ...References1. Astin JA, Harkness E, Ernst E. The efficacy of “distant healing”: a systematic review of randomized trials. Ann Intern Med. 2000;132:903-10. [PMID: 0010836918] LinkGoogle Scholar2. Wulff HR, Pederson SA, Rosenberg R. Philosophy of Medicine. Oxford: Blackwell; 1986. Google Scholar3. Linde K, Clausius N, Ramirez G, Melchart D, Eitel F, Hedges LV, et al. . Are the clinical effects of homeopathy placebo effects? A meta-analysis of placebo-controlled trials. Lancet. 1997;350:834-43. [PMID: 0009310601] CrossrefMedlineGoogle Scholar4. Vandenbroucke JP. 175th anniversary lecture. Medical journals and the shaping of medical knowledge. Lancet. 1998;352:2001-6. [PMID: 0009872263] CrossrefMedlineGoogle Scholar5. Goodman SN. Toward evidence-based medical statistics. 2: The Bayes factor. Ann Intern Med. 1999;130:1005-13. [PMID: 0010383350] LinkGoogle Scholar Author, Article, and Disclosure InformationAuthors: Ted J. Kaptchuk, OMDAffiliations: Harvard Medical School; Boston, MA 02215 (Kaptchuk) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe Efficacy of “Distant Healing” John A. Astin , Elaine Harkness , and Edzard Ernst Distant Healing John Astin , Elaine Harkness , and Edzard Ernst Distant Healing Kevin Courcey Metrics Cited byWe are All Bayesian, Everyone is Not a Bayesian‘Are We One Body?’ Body Boundaries in Telesomatic ExperiencesIntercessory prayer and healing prayer 20 March 2001Volume 134, Issue 6 Page: 532 Keywords Homeopathy Jewish people Systematic reviews ePublished: 20 March 2001 Issue Published: 20 March 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
The significance of yellow bone. Evidence for tetracycline in adult human bone
Authors: S. A. Oklund
Journal: JAMA (1981)

Tetracycline binds to growing bone and imparts a brilliant and fluorescent yellow to this tissue. The cumulative deposition of tetracycline in cortical bone during many years resulted in levels of 156, 270, and 290 μg/g, respectively, of bone wet weight in three patients who used this antibiotic for acne vulgaris. Although tetracycline in high doses impairs mineralization of growing bone in the fetus and young, its long-term use in therapeutic dosages in the human adult has no known deleterious effect. Yellow bone appears safe for the human carrier and as a transplantable tissue. (<i>JAMA</i>1981;246:761-763)
Medico-Chirurgical Transactions.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PHENOLPHTHALEIN DERMATITIS
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Erratum
Authors: Giancarlo Isaia, Giovanni Targher, Eugene Tull, Robert Hegele, Stewart Harris, Bernard Zinman, Anthony Hanley, Henian Cao
Journal: Diabetes Care (2001)

Evidence of Macrovascular Complications Elevated plasma total homocysteine (tHcy) levels are a powerful risk factor for atherosclerotic vascular disease (1), but it is still unclear by which pathophysiological mechanisms tHcy may promote atherothrombosis.In both experimental animal and cell culture studies (2,3), acute hyperhomocysteinemia induces endothelial dysfunction, leading to a low-grade inflammatory state that results in increased leukocyte adher-
Joining Forces for Children's Health
Authors: Kathryn S. Brown
Journal: Environmental Health Perspectives (1998)

From airborne particulatesto pesticide-laden fruit, children probably encounter more pollutants than adults. Because their bodies are rapidly developing, children may react more strongly to these toxins, too. The NIEHS hopes to learn more about how several hazardous agents specifically affect kids. Together, the NIEHS and the EPA are spending $10 million to establish up to six Centers for Children's Environmental Health and Disease Prevention Research. The CDC, a third partner,will later help apply center research to public health.
Abstract 2515: Comprehensive analysis of the histologically distinct components of an adenosquamous carcinoma of the lung
Authors: Arthur Krause, Maria R. De Filippo, Thomas Lorber, Spasenija Savic, Salvatore Piscuoglio, Charlotte K. Ng, Lukas Bubendorf
Journal: Cancer Research (2019)

Abstract Background: Adenosquamous carcinoma (ASC) is a rare subtype of non-small-cell lung cancer, consisting of an adenocarcinoma (AC) and a squamous cell carcinoma (SCC) component. Little is known about the molecular makeup of the two components in ASC. In this study, we applied a comprehensive analysis including whole exome sequencing (WES) and RNA sequencing to understand the evolutionary relationship between the AC and SCC components of an ASC of the lung. Methods:FFPE tumor tissue of three ASC patients was used in this study. Samples were stained with FastRed to visualize the nuclei. AC and SCC components were scratched separately from histological slides for DNA and RNA extraction. WES analysis was performed to assess the mutational profile and copy number alterations (CNAs). The transcriptome was investigated in each of the components using RNA sequencing. Results:WES analysis of the AC and SCC components of one patient revealed a common trunk of 118 mutations, including driver mutations EGFR exon 19 deletion and TP53 p.192*, indicating a common clonal origin of the components and the presence of bona fide drivers in the common ancestor. AC shows more private mutations than SCC (234 vs 134). Potential drivers are private to AC included TP53 and AKT1 mutations, while TLX1 and TRBV5-1 mutations are restricted to SCC. AC and SCC have highly similar CNA profiles, suggesting that all CNAs are early evolutionary events of the ASC. Mutational signature of the truncal mutations is similar to that of the mutations private to AC, while mutations private to SCC showed a distinct pattern enriched in T&amp;gt;G, suggesting that SCC may have derived from an AC ancestor cell. Transcriptomic profiling shows that genes related to oxidative phosphorylation, fatty acid metabolism and peroxisome pathways are highly expressed in AC, in contrast to genes related to epithelial-mesenchymal-transition, hedgehog signaling and IL6-JAK-STAT3-signaling pathways in SCC. Conclusion:Macroscopic dissection and separate analysis of the histologically distinct components of an ASC of the lung demonstrated the clonal relatedness of the AC and SCC. The diverse phenotype of the components is associated with distinct genetic profiles and mutational signatures. Analysis of additional ASCs of the lung may reveal genetic and/or transcriptomic underpinnings of the phenotypes. Citation Format: Arthur Krause, Maria R. De Filippo, Thomas Lorber, Spasenija Savic, Salvatore Piscuoglio, Charlotte K. Ng, Lukas Bubendorf. Comprehensive analysis of the histologically distinct components of an adenosquamous carcinoma of the lung [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2515.
The efficacy of post-deployment balloon dilatation for the current generation stents: A serial volumetric intravascular ultrasound study Seung-Ho Hur, Katsuhiro Kitamura, Yoshihiro Morino, Yasuhiro Honda, Michael Jones, Kenneth S. Korr, Bernard Reen, III, Christopher J. Cooper, Gary S. Niess, Leonard Christie, Woodrow Corey, John Messenger, Paul G. Yock, Frank Cummins, Peter J. Fitzgerald. Stanford University, Stanford, CA
Journal: Journal of the American College of Cardiology (2001)
Journal of Pediatrics, St. Louis
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal