tbuckley/cabot-search huggingface dataset:
The Croonian Lectures on the Difference between the Sexes in Regard to the Aspect and Treatment of Disease
Authors: J. B. Hicks
Journal: BMJ (1877)

It will be seen that the phenomena observed during life and the ap- pearances after death from the inhalation of the nitrous oxide gas are precisely similar to those which result from suspension of the respiration in the human being and in the lower animals.It is evident, from the many thousands of cases in wvhich the gas has been given and the extreme rarity of a fatal accident from its use, that, in the hands of a skilled and careful operator, no great risk attends the employment of this anaesthetic; but it is also obvious that, to a patient with a feeble fat heart, the distension of the right cavities which accompanies the disappearance of the radial pulse and the general lividity of the features must be attended with some degree of risk, and the danger must be increased when, the muscles of the trunk and limbs being convulsed, the pressure of the contracting muscles upon the veins drives the blood forcibly towards the right cavities of the heart, and so adds to their distension.
Eighth International Convocation on Immunology
Journal: JNCI Journal of the National Cancer Institute (1981)

Journal Article Eighth International Convocation on Immunology Get access JNCI: Journal of the National Cancer Institute, Volume 67, Issue 6, December 1981, Page 1369, https://doi.org/10.1093/jnci/67.6.1369-d Published: 01 December 1981
Impact of Modafinil on Prefrontal Executive Function in Schizophrenia
Authors: Michael D. Hunter, Venkatasubramanian Ganesan, Iain D. Wilkinson, Sean A. Spence
Journal: American Journal of Psychiatry (2006)

Objective: The purpose of this study was to investigate the acute effects of modafinil on prefrontal activation and cognitive control of motor activity in people with schizophrenia and prominent negative symptoms. Method: In a crossover design, 12 subjects with schizophrenia were studied twice, receiving either modafinil or placebo prior to functional magnetic resonance imaging (fMRI). Inside the scanner, they performed a task probing cognitive control that required deliberate variation of motor activity in time. Results: Modafinil administration was associated with significantly greater activation of the dorsolateral prefrontal cortex during fMRI. Its physiological and behavioral effects were correlated. This was most evident in individuals with worse baseline executive function. Focal response to modafinil in the left dorsolateral prefrontal cortex and baseline letter fluency scores predicted most of the variance in the drug's effect on cognitive control. Conclusions: Modafinil did not improve cognitive control in all schizophrenia patients. Increased activation in the dorsolateral prefrontal cortex and in neuropsychological performance were observed in patients with suboptimal baseline function.
Role of adhesion molecules in the development of massive hepatic necrosis in rats
Authors: S Mochida, A Ohno, M Arai, T Tamatani, M Miyasaka, K Fujiwara
Journal: Hepatology (1996)

Massive hepatic necrosis develops after endotoxin administration in rats pretreated with heat-killed Propionibacterium acnes as a result of microcirculatory disturbance caused by endothelial cell destruction by activated macrophages in the hepatic sinusoids. Immunohistochemical hepatic expression of intercellular adhesion molecule-1 (ICAM-1) and lymphocyte function-associated antigen 1 α (LFA-1 α) and the effect of monoclonal antibodies against both adhesion molecules on liver necrosis provoked after endotoxin administration was studied in these rats. There were increased stains of ICAM-1 in endothelial cells and LFA-1 α in macrophages in the hepatic sinusoids in Propionibacterium acnes -pretreated rats compared with normal rats. Such stains were further increased soon after endotoxin administration, followed by development of hepatic necrosis. Monoclonal antibodies against both adhesion molecules significantly attenuated the extent of liver injury compared with controls, without affecting the infiltration and activation of hepatic macrophages. Polyclonal antibodies against polymorphonuclear leukocytes eradicated circulating neutrophils, but did not change such liver injury, although gum arabic, which suppressed macrophage activation, attenuated the extent of liver injury. Thus, adhesion between endothelial cells and activated macrophages in the hepatic sinusoids via ICAM-1 and LFA-1 α is essential for the initiation of massive hepatic necrosis of this type. Contribution of neutrophils seems less likely.
Emergence of Antibiotic-Resistant Bacteria
Authors: Maxwell Finland
Journal: New England Journal of Medicine (1955)

Changes in Microflora during Antibiotic AdministrationThe material presented thus far has dealt with clearly identifiable organisms, which, for the most part, are primary pathogens and the chief targets against which the antibiotics were directed — mostly during therapy, but also in the prophylaxis of infections. Although the literature concerning these organisms was by no means exhaustively covered, and that concerning other pathogens was not considered, it seems clear that such organisms rarely become resistant within the primary host as a result of adequate antimicrobial treatment of specific infections. Exceptions are Myco. tuberculosis to various agents under certain conditions and, . . .
JAMA Dermatology
Journal: JAMA Dermatology (2014)

Mission Statement JAMA Dermatology publishes information concerning the skin, its diseases, and their treatment.Its mission is to explicate the structure and function of the skin and its diseases and the art of using this information to deliver optimal medical and surgical care to the patient.We attempt to enhance the understanding of cutaneous pathophysiology and improve the clinician's ability to diagnose and treat skin disorders.This journal has a particular interest in publishing clinical and laboratory studies that reveal new information pertinent to the interests and needs of the medical dermatologist, dermatologic surgeon, and all those concerned with state-of-the-art care of cutaneous disease.We believe that knowledge derived from well-designed clinical trials and studies of cost-effectiveness are especially important for improving the practice of dermatology.Studies that increase the understanding of the outcome of treatment or the means by which the burden of dermatologic disease can be measured and reduced to promote the health of patients with skin disease will receive special priority.The journal regularly publishes reports on clinical investigations, editorials, and reviews.It also features reports and discussions on clinicopathologic correlations; clinical disorders of unique didactic value; pharmacologic, medical and surgical therapeutics; and ethical, moral, socioeconomic, and political issues.
Cancer survivorship in the rural U.S. Columbia Pacific: A pilot study.
Authors: Jennifer L. Lycette, Paulina Cockrum, Venus Fromwiller, Kerri M. Winters-Stone
Journal: Journal of Clinical Oncology (2017)

e21614 Background: We provide the only fully staffed cancer center in the rural Columbia Pacific, serving multiple counties in OR and WA. Rural areas can lack resources to provide comprehensive survivorship care. Higher rates of medical comorbidities and socioeconomic barriers add challenges to rural survivorship. We conducted a pilot study to 1) develop a program for lifestyle and behavior modifications to fit the needs of our patients in our rural community and 2) determine feasibility and preliminary efficacy of a survivorship program for breast cancer patients. Methods: 9 women with stage I-III breast cancer completed a 12-week program consisting of 1:1 meetings every 2 weeks with a physical therapist and registered dietician; health coach support; and access to a social worker. The following pre-post measures of physical health were taken: fasting lipids and glucose, HbA1C, waist circumference, blood pressure, BMI, 3-day physical activity log and food journal, joint range of motion, and muscle strength. Pre-post well-being was assessed by EORTC QLQC30 and focus groups. Results: Decreases in systolic BP, weight, waist circumference, fasting glucose, and HbA1c were seen in a majority of participants; however, only decreases in waist circumference reached statistical significance (p = .043). On post-program survey using a 0-10 rating scale, program acceptability was rated at an average of 7, and likelihood to continue at an average of 9.4; however, overall QOL rating had no change. Focus group feedback indicated participants valued dietician visits, but requested more social work support, exercise customization, and group support to foster mentoring, education, and sense of community. Conclusions: Developing a rural comprehensive survivorship care program locally is feasible. More work is needed to translate physical health goals into enhancement of well-being and improved QOL of rural cancer survivors.
SUBJECT INDEX
Journal: Circulation Research (1963)

Absorption, capillary, coefficient in shock, 105 Acetyl strophanthidin antagonistic effects on sinoatrial node of adrenergic stimulation and, 388 effect on myocardial electrolyte and water content in congestive heart failure, 207 Acidosis, epinephrine response during, 64 Actin amino acid composition in cardiac and skeletal muscle, 474 from heart muscle, isolation and purification of, 187 properties of, 187 Adenosine diphosphate, blood platelet and cell aggregation, 392 Adrenal glands, during myocardial necrosis, .159Adrenergic nerve, stimulation, antagonistic effect on sinoatrial node, 388 Allantoic fluid, and influenza A virus in production of congenital cardiac disease in chick embryo, 572 Alveoli, gas diffusion to large pulmonary vessels, 71 Amino acids, in aetin of cardiac and skeletal muscle, 474 e-Aminocaproic add, effect on fibrinogen turnover, 432 Anemia, dextran, myocardial blood flow, and oxygen untake in, 172 Aneintensin effort, on intact forearm veins of man.239 in lymnh and renal venous blood, production by low pressures, 336 re"al effects in pregnancy, 232 Aorta atherotrenesis, histoehemioal studies, 401 l>Tf>ss»re.transients i".585 thromboplastic and fibrinolytic activity in wall lavers, 253 Arrhythmia dependence upon electric current and cardiac cvcle.21 digitalis-induced, effects of reserpine and /JTM 10, 149 following condenser discharge, 21 intracardiac pressures and, 39 ouabain-induced, 132 Arteries carotid injection of radioalbumin and effects of COs on fprehml h T nndvram'cs, 436 poststenotic dilatation, 537 computer aralysis of pressure and flow, 3 coronary, atherogenesis, 401 femoral, poststenotic dilatation, 537 poststenotic dilatation, 537 pulmonary constricted, cardiac performance during exercise, 410 hypertension in newborn calf, 557 oxygen and nitrogen ventilation on flow and pressure, 478
Genome-wide Association Study of Genetic Loci and Alzheimer Disease
Authors: Abraham M. Brown
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical Pharmacol &amp;amp; Therapeutics, St. Louis
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MEDICINE AND THE BEHAVIORAL SCIENCES
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PROTECTION FOR THE RED CROSS.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 1552: Cardioplegic Arrest And Subsequent Reperfusion Induce Urocortin Expression In Non-apoptotic Cardiac Cells Selectively Associated With Mitochondrial Relocation Of PKCϵ
Authors: Carol Chen-Scarabelli, Zhaokan Yuan, Giuseppe Faggian, Francesco Santini, Alessio Rungatscher, Maddalena Tessari, Renato Ragusa, Joshua Martindale, Justin DiRezze, David Patel, Riccardo Raddino, Alessandro Mazzucco, Louis Saravolatz, Tiziano M Scarabelli
Journal: Circulation (2007)

BACKGROUND: Cardioplegic arrest and subsequent reperfusion inevitably expose the heart to an iatrogenic ischemia/reperfusion injury (iIRI). We previously reported that iIRI caused mitochondria-initiated myocyte apoptosis, but also induction of urocortin (Ucn), an endogenous cardioprotective peptide. We also showed that Ucn induced PKCϵ-mediated opening of mitochondrial K ATP channels in isolated heart mitochondria. AIM: To investigate, in patients exposed to iIRI, the cardioprotective role and the mechanism of action of Ucn, with respect to PKCϵ expression, activation and relocation. METHODS AND RESULTS: Two sequential biopsies were obtained from the right atrium of 25 patients undergoing coronary artery bypass grafting at the start of grafting (internal control) and 10 mins after release of the aortic clamp. Mean values of ejection fraction, aortic cross-clamping time and number of grafts were 51±8; 48±8 mins; and 3.6±0.5 respectively. In hearts exposed to iIRI, RT-PCR and immunostaining showed Ucn induction at the mRNA (255% of basic levels, p&lt;0.05) and protein level (28±2.1% positive myocytes vs 3.1±0.6% of internal control; p&lt;0.01) respectively. iIRI also induced a selective increase of PKC-ϵ mRNA (225% of internal control; p&lt;0.05) and a two-fold overexpression of total PKCϵ isoform (assessed by Western blotting; p&lt;0.05), which paralleled a 2.9 fold increase in PKCϵ phosphorylation (p&lt;0.01). TUNEL positivity (&lt;0.1% and 2.9±0.7% positive myocytes pre- and post-iIRI respectively; p&lt;0.01) was only seen in Ucn-negative cells, and, of note, Ucn-positive myocytes showed concurrent mitochondrial relocation of phosphorylated PKCϵ, as documented by mitochondrial-activated PKCϵ colocalization, calculated by confocal microscopy with an image analyzer software (% overlap: 57±5 vs 11±2 in Ucn-negative cells; p&lt;0.01). Western blotting carried out in pools of cytosolic and mitochondrial fractions confirmed a 2.5 fold increase in mitochondrial localization of phosphorylated PKC-ϵ following iIRI (p&lt;0.05). CONCLUSIONS : In patients exposed to iIRI, Ucn expression in viable cells was selectively associated with phosphorylation and mitochondrial relocation of PKCϵ, suggesting a cardioprotective role for endogenous Ucn in the human heart.
Cancer, New York
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Preventive dentistry. I. Dental caries
Authors: J. C. Greene
Journal: JAMA (1989)

Primary care physicians and nurses have numerous opportunities to assist in the prevention of dental caries, periodontal diseases, malocclusion, trauma to the mouth and teeth, and oral cancer. This is the first of two articles that provide background for the US Preventive Services Task Force recommendations for interventions by physicians, nurses, and other clinicians to prevent these oral diseases and conditions. Physicians and other health professionals are urged to be aware of these opportunities and to take appropriate action in collaboration with the patient's dentist. (<i>JAMA</i>. 1989;262:3459-3463)
Correction: Improved control of brittle Parkinsonism by separate administration of levodopa and benserazide
Journal: BMJ (1982)

one patient had a false-negative test for additional coronary artery disease.The predictive value of a positive test (the percentage of patients with a positive test who have additional disease) was 100%,/0 there being no false-positive results.Thus, the sensitivity of the stress test in patients with anterior infarction was 96%' and the specificity 100%.Inferior myocardial infarction-Twenty-two (78 6%' ) of the 28
Special Article.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal