tbuckley/cabot-search huggingface dataset:
In Brief
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Parallel 7: Mechanisms of Hepatotoxicity
Authors: Cynthia Leveille-Webster, Andrea Johnston, Mohammed Anwer, Kunimaro Furuta, Yuichi Yoshida, Takashi Kizu, Satoshi Ogura, Mayumi Egawa, Norihiro Chatani, Yoshihiro Kamada, Shinichi Kiso, Tetsuo Takehara
Journal: Hepatology (2014)
TESTS OF ARTIFICIAL RESPIRATION
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dissecting <i>g</i>
Authors: Andreas Demetriou
Journal: Behavioral and Brain Sciences (2006)

Two studies substantiating Blair's main postulates are summarized. The first study showed that fluid cognition, reasoning, and perceived competence about reasoning are separate and equipotent partners in g . The second study showed that reasoning, understanding of emotions, and perceived competence about reasoning and emotions partake in the formation of g , substantiating Blair's claim that cognition and emotion are linked in the brain.
Acute Labyrinthitis
Authors: W. L. Burrowes
Journal: BMJ (1952)

MEDIsHJOINL that he should have adequate time to keep in close contact with all the mothers and perhaps to assist the sister in the instruction of nurses.It is noteworthy that Illingworth et al. found the services of two registrars to be necessary at the Jessop Hospital for Women, Sheffield.Where supervision is not adequate self-demand is likely to degenerate into regular feeding, with " a little drop in between if he cries."This happened in our ward not super- vised by the registrar.We wish to thank Professor T. N. A. Jeffcoate and Mr. C. H. Walsh for permitting us to make a trial of this method of feeding
Dithranol cream
Authors: R.H. Seville, G.B. Walker, M. Whitefield
Journal: British Journal of Dermatology (1979)

Journal Article Dithranol cream Get access R.H. Seville, R.H. Seville Beaumont Hospital, Lancaster Search for other works by this author on: Oxford Academic Google Scholar G.B. Walker, G.B. Walker Beaumont Hospital, Lancaster Search for other works by this author on: Oxford Academic Google Scholar M. Whitefield M. Whitefield Dermal Laboratories, Hitchin Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 100, Issue 4, 1 April 1979, Pages 475–477, https://doi.org/10.1111/j.1365-2133.1979.tb01654.x Published: 01 April 1979
History of Accreditation of Medical Education Programs
Journal: JAMA (1983)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Relevance of Short-Term Carcinogenicity Tests to the Study of the Carcinogenic Potential of Urban Air
Authors: D. G. Harnden
Journal: Environmental Health Perspectives (1978)

It is now accepted that screening for carcinogens in animals is expensive and demonstrates carcinogenic potential rather than actual carcinogenicity in man. A number of short-term tests which depend on mutagenicity, stimulation of DNA repair, ability to produce chromosome damage or other actions, and which correlate at least to some extent with carcinogenic potential, have been devised. These have the advantages of being rapid and cheap. Some can be carried out by using human cells. They may have advantages in the context of air pollution since they are sensitive down to very low dose levels and since they can deal with complex mixtures. Combinations of such tests may be of more value than any single test. Their particular value may be as a preliminary screening procedure in a tiered testing programme which may have high predictive efficiency.
Abstract 4345: Identification of Responders to CRT by Stress Echo: No Contractile Reserve, No Party
Authors: Quirino Ciampi, Lorenza Pratali, Rodolfo Citro, Massimo Della Porta, Marcello Piacenti, Giovanni Gregorio, Bruno Villari, Eugenio Picano
Journal: Circulation (2008)

Cardiac resynchronization therapy (CRT) is increasingly used, but the identification of “responders” remains challenging. Aim: to assess the value of rest (for dyssynchrony, DYS) and stress (for contractile reserve, CR) echo to identify responders. In a prospective, multicentre study design, we enrolled 55 patients (age 69±8 years; 60% with ischemic etiology) referred to CRT, all with LV ejection fraction ≤35%, NYHA ≥IIb and QRS duration ≥130 milliseconds. All patients underwent a baseline study for DYS (Tissue Doppler criteria, 6-segment approach, Bax dyssynchrony index &gt; 65 ms) and dobutamine stress echo (up to 40 mcg/Kg/min, with presence of CR defined as a wall motion score index, WMSI, increase &gt; 0.20) with core lab reading. “Responders” were identified by clinical (survivors, with NYHA class improvement ≥1 grade) and/or echocardiographic (LV end-systolic volume, ESV, decrease ≥15% at 6-months follow-up) criteria. In the follow-up, 28 (51%) patients were responders to CRT. At individual patient analysis, CR was more often associated with a favourable outcome whereas DYS criteria were equally present in the 2 groups: see figure . At multivariate analysis, CR (OR=6.2, 95% CI=1.4–27.6) and ischemic etiology (OR=0.20, 95% CI=0.05–0.73) were the best predictors of clinical and echo response to CRT, regardless of DYS. Patients with CR during stress echo show a favourable clinical and reverse LV remodelling response to CRT. This finding shifts the focus from electrical (DYS) to the myocardial substrate of functional response to CRT: no muscle, no party!
Memory T cells represent the predominant lymphocyte subset in acute and chronic liver inflammation
Authors: R Volpes
Journal: Hepatology (1991)

T cells can be divided into two main phenotypic subpopulations–i.e., the CD45RA-positive (2H4-positive) “naive” subset and the CD45RO-positive (UCHL1-positive) “memory” subset. In light of this recent functional reinterpretation of T-lymphocyte subpopulations, we reinvestigated the composition of the inflammatory infiltrate in liver biopsy specimens from patients with acute and chronic hepatitis. In normal liver, the few scattered mononuclear cells present in portal tracts and in the intralobular parenchyma consisted of both CD45RA-positive (2H4-positive) naive and CD45RO-positive (UCHL1-positive) memory T cells. In inflammatory liver diseases, portal tract and periportal and intralobular areas of inflammation consisted virtually only of CD45RO-positive (UCHL1-positive) memory T cells, which strongly expressed the CDw29 (4B4) antigen, and the adhesion molecules LFA-1, CD2, LFA-3, CD44 and VLA-4 and the activation marker human leukocyte antigen-DR. These results indicate that activated memory T cells represent the predominant subpopulation of lymphocytes in areas of liver inflammation. Memory T cells strongly express various homing receptors and adhesion molecules, which probably allow them to accumulate at inflammatory sites and to strengthen interaction with target cells. Furthermore, the increased number of memory T cells with enhanced interferon-γ production in areas of liver inflammation may contribute to the maintenance and up-regulation of immune responses occurring in inflammatory liver diseases. (HEPATOLOGY 1991;13:826–829.)
JAMA Internal Medicine
Authors: Phil Fontanarosa, Annette Flanagin, Brenda Gregoline, Lauren Fischer, John Mcfadden, Karen Boyd, Rochelle Lodder, Diane Cannon, Connie Manno, Fred Marshall, Laura Copyreaders, Catherine Adamczyk, Stephanie Alden, Jan Beckmeyer, Mary Clavey, Paula Coerver-Connolly, Roya Glitman, Laura Khatiblou, Donna King, Caroline Thordsen, Wanda Assistant, Larry Bryant, Monica Mungle, Elaine Managers, Staff Gardner- Gullens, Fanny Brown, Paul Frank, Peter Kim, Rachell Lozano, Michaela Mark, Kathryn Muskovich, Gale Saulsberry, Michael Berkwits, Michelle Kurzynski, Eric Butkus, Will English, Craig Mccaffrey, Reuben Rios, Ronna Henry, Joshua Bird, Karen Bucher, Samantha Welker, David Song, Deputy Livingston, Thomas Cole, Marla Hall, Deanna Willis, Yolanda Davis, Joseph Thornton, Preeti Malani, Deanna Bellandi, Jim Periodical, Thomas Easley, Brian Shields, Monica Smith, Jeffery Bonistalli Manager, Kathy Russell, Mirna Monal, Stacey Mchugh, Tim Melroy, Marketing Thornbury, Tricia Castellano, Thalia Moss, Mike Harvey, Susan Henning, Saskia Bolore, Gretchen Linder, Brian Mccartney, David Baum, Rebecca Haas, Christine Hearne, Irma Lara, Ron Marketing, Paul Gee, Matt Herron, Elizabeth Solaro, Geoffrey Flick Managers, Rick Bell, Lindsay Dawson, Michael Mcgraw, Romando Rossini, Stacy Staff, Millette Jackson-Bates, Karen Adams-Taylor, Karl Elvin, Jaye Mize, Sean O'donnell, Sue Managers, David Antos, Chris Borden, Debbie Camp, Lydia Cruz, Scott Curl, Diane Darnell, Colleen Kelly, Chris Meyer, Annemarie Neff, J Neff, Sean Ohlson, Phil O'leary, Bill Pedone, Susan Price, Denise Steinhauser, Production Services, Kim Boler, Rhonda Brown, Timothy Burke, Daniel Degroot, Jordynn Farrar, Euwanaha Joiner-Smith, Tiffany Jones, Cindy Rendlen, Ellen Yoshihara, Circulation Services, Julie Burton, Dexter Golden, Erin Hinchcliff, Maria Nienhaus, Noemi Rivera, Geneine Van, Someren Composition, New Media, Gail Barrett, Regina Brownlee, Amanda Camino, Brenda Chandler-Grayer, Emily Dunn, Amy Evers, Teri Hutchison, Mary Kuranda, Joshua Lampinen, Nathan Mitre, Patricia Panek, La Son, Diggs Sledge, George Thomson Graphics, Joe Amft, Maria Duda, Fred Furtner, Carolyn Hall, Maria Kowalkowski, Proofreading Carol, Joy Farrell, Daniel James, Judith Literskis, Teresa Omiotek, Sam Wilder, James Madara, Bernard Hengesbaugh, Jeffrey Tabas, San Francisco, Gregory Marcus, Nora Goldschlager, Elsayed Soliman, Carolina Cme, Rebecca Larson, Deborah Grady, Rosemary Gibson, Virginia Arlington, Howard Bauchner, Rita Redberg, Shannon Brownlee, Tanner Caverly, Ann Arbor, Brandon Combs, Christopher Moriates, Neel Shah, Robert Steinbrook, New Haven, James Colbert, Judyann Bigby, Ezekiel Emanuel, Lara Goitein, Santa Fe, New Mexico, Chi-Yuan Hsu, Kurt Kroenke, Grace Lin, Mary Mcdermott, C Noel, Bairey Merz, Los Angeles, Samia California, Robert Phillips, Judith Prochaska, Kathryn Rexrode, Mary Tinetti, Nicolas Rodondi, Iona Heath, Mitchell Katz, Patrick California, John Boscardin, John Neuhaus, Kenneth Covinsky, Joseph Ross, Blake Charlton, Rachel Stern, Charlotte Dudley, Kate Denevan
Journal: JAMA Internal Medicine (2015)
SURGEON-GENERAL STERNBERG: TWO OPINIONS.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THOMAS BLIZARD CURLING (1811-1888) CURLING'S ULCER OF THE DUODENUM
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SOCIETY NEWS.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Malarial Eye Affections: a Correction
Journal: BMJ (1899)

THYROID desires to hear of a home where a female cretin of about I2 years of age could be taken in for 25S. to 30S. a week..AJAx desires to have the experience of any member who has followed the method of treatment of the morphine habit by bromide, recommended by Dr. Neil Macleod in the JOURNAL of July Iotli, I897, and April x5th, I899.He is desirous of placing a lady under care for treatment in this way.J. A. W. would be obliged if any member would give hiim information as to the cause and treatment of the following case: A lady, aged 46, has for years been subject to the periodical appearance of large patches of ecchlymosis on lher upper and lower limbs, especially the thighs, disappearing after a few days.She is in perfect health, and her catamenia are regular.1 "THE GRAPE FRUIT."J. A. T. wants to know about the '"grape fruit" said to come from the Bahamas, and to grow as large as a melon * whether it can be got in London, and if it is of any use in cllronic cystitis as has been alleged.TREATMENT OF COLITIS.G. T. G. asks for suggestions for the treatimient of the following case: A young woman lhas suffered for more than two years from catarrhal enteritis of tile large intestine, passing.large mucous casts almost daily.The ordinary remedies have been ttied and consultants appealed to without success.MEDICAL AID AssoCIATIONS.F. M. B. asks whether the holding of the appointment of medical officer to a medical aid association is illegal.* The holding of such appointments is not illegal, but having regard
A multicenter randomized phase III trial of capecitabine with or without irinotecan driven by UGT1A1 in neoadjuvant chemoradiation of locally advanced rectal cancer (CinClare).
Authors: Zhen Zhang, Xinchen Sun, Anwen Liu, Yuan Zhu, Yaqun Zhu, Tao Zhang, Jianhui Jia, Shisheng Tan, Junxin Wu, Juying Zhou, Xin Wang, Jialin Yang, Yuanyuan Zhao, Hongyan Zhang, Chen Zhang, Gang Cai, Ji Zhu
Journal: Journal of Clinical Oncology (2019)

3510 Background: Our phase I/II study identified irinotecan dose differentiated by UGT1A1 genotype in the neoadjuvant CRT and showed improved pCR. The objective of this phase III study was to further investigate irinotecan combined with capecitabine-based chemoradiotherapy as preoperative treatment for locally advanced rectal cancer. Methods: We underwent a prospective, randomized, open-label, multicenter, phase 3 trial in China from Nov.2015 to Dec.2017. Eligible patients with clinical stage T3-4 and/or N+ rectal adenocarcinoma were randomly allocated to two arms. The approach in control arm (Arm A, n = 180) was pelvic radiation of 50 Gy/25 fractions with concurrent capecitabine 825 mg/m 2 twice daily 5 days per week, followed by a cycle of XELOX two weeks after the end of CRT. The experimental arm (Arm B, n = 180) was pelvic radiation with capecitabine 625 mg/m 2 twice daily 5 days per week and combined with weekly irinotecan. The irinotecan dose was used based on UGT1A1 genotype of 80mg/m 2 for UGT1A1*1*1 or 65mg/m 2 for UGT1A1*1*28 weekly, followed by a cycle of XELIRI. The primary endpoint is pathological complete response (pCR). This trial was registered with ClinicalTrials.gov, number NCT02605265. Results: Surgery was performed in 86.5% and 88.2% of patients in two groups, with 38.9% and 30.5% of patients got abdominoperineal resection respectively. The pCR rate was 17.5% in Arm A and 33.8% in Arm B (P = 0.001). Four and 6 patients maintained a complete clinical response status at least 12 months and were marked as cCR. The CR rate, including pCR and cCR, was 17.4% in Arm A and 33.1% in Arm B (P = 0.001). The most common grade 3-4 adverse events during preoperative treatment were leucopenia (3.4% vs. 25.3%), neutropenia (1.7% vs. 19.7%) and diarrhea (1.7% vs. 13.5%) in two arms. The overall rate of surgical complications were not significantly different between arms (11.0% vs. 14.6%). Conclusions: Adding irinotecan guided by UGT1A1 to capecitabine-based neoadjuvant chemoradiotherapy significantly increases complete tumor response. The treatment toxicities were increased but tolerable. This treatment can be as an option for ‘watch and wait’ approach. Clinical trial information: NCT02605265.
Symposium on Steroid Hormone Action and Cancer
Journal: JNCI Journal of the National Cancer Institute (1975)

Journal Article Symposium on Steroid Hormone Action and Cancer Get access JNCI: Journal of the National Cancer Institute, Volume 54, Issue 6, June 1975, Page 1498, https://doi.org/10.1093/jnci/54.6.1498e Published: 01 June 1975
Neurology
Authors: Robert J. Joynt
Journal: JAMA (1993)

The changes in the practice of neurology have been dramatic in the past decade. Physicians graduating over 20 years ago recollect a specialty with great intellectual challenges but with few therapeutic opportunities. Now therapy is advancing in many areas, and major trials are providing information about treatment efficacy, failures, side effects, and complications. Therapies are based on the fundamental knowledge of the disease processes learned through the use of new research techniques. There here is now some promise of altering the course of multiple sclerosis by vaccine therapy, intravenous immunoglobulin, or use of interferon. The vaccine is made up of immunogenic fragments of myelin basic protein. Experimental studies indicate that this vaccination will largely prevent the induction of allergic encephalomyelitis, a model for multiple sclerosis, in laboratory animals.<sup>1</sup>Intravenous immunoglobulin has been used for a number of autoimmune disorders, including chronic inflammatory demyelinating neuropathy, myasthenia gravis, and inflammatory myopathies.