tbuckley/cabot-search huggingface dataset:
Reply to Tine Hajdinjak and Nadja Kokalj-Vokač’s Letter to the Editor re: Re: Mecedes Marín-Aguilera, Lourdes Mengual, María José Ribal et al. Utility of Fluorescence In Situ Hybridization as a Non-invasive Technique in the Diagnosis of Upper Urinary Tract Urothelial Carcinoma. Eur Urol 2007;51:409–15 and Alan M. Nieder, Mark S. Soloway and Harry W. Herr. Should We Abandon the FISH Test? Eur Urol 2007;51:1469–71. Eur Urol 2007;52:287–9
Authors: Johannes Alfred Witjes
Journal: European Urology (2007)
Correlates of distress for cancer patients: Results from multi-institution use of holistic patient-reported screening tool.
Authors: Christine B. Weldon, James I. Gerhart, Frank J. Penedo, Mary Pasquinelli, Joanna Martin, Paramjeet Khosla, Teresa Lillis, Shelly S. Lo, Lawrence Eric Feldman, Catherine Deamant, Rosa Berardi, Harry Miranda, Carol Newsom, Anne Bowman, Betty Roggenkamp, Julia Rachel Trosman
Journal: Journal of Clinical Oncology (2019)

199 Background: The Commission on Cancer (CoC) Standard 3.2 requires distress screening and indicated action for cancer patients. NCCN and ASCO supportive care and age-related guidelines include patient reported concerns beyond distress. This study compares PHQ4 scores to other patient reported concerns. Methods: The Coleman Supportive Oncology Collaborative aggregated “best of” screening tools to assess patient reported needs and concerns aligned with CoC, NCCN and ASCO guidance. This supportive care screening tool was implemented at 8 sites from July 2015 thru July 2018. Analysis used chi squared test. Results: Most patients, 86% (10,635/12,295), reported one plus concerns and/or above threshold scores on PHQ4, PROMIS Pain, Fatigue or Physical Function. A chi squared comparison of patients with at least mild distress on PHQ4 to patients with no distress resulted in p values &lt; .0001 for every screening category. Conclusions: Patients with a PHQ4 distress score of mild, moderate or severe also reported statistically significant levels of practical, family, physical, nutrition and treatment concerns. These patients also scored threshold levels for PROMIS Pain, Fatigue, and Physical Function. Screening only for distress without screening for other patient concerns may direct patients to services that do not address or focus on the underlying cause of the distress. [Table: see text]
Seat-Belt Hernia
Authors: Elliot S. Hurwitt
Journal: JAMA (1965)

THE USE of automobile seat belts has been shown to be effective in reducing mortality and severity of injuries sustained during automobile accidents, and has found increasing acceptance throughout the United States as well as other parts of the world. With the increase in use of automobile seat belts, one may anticipate finding a gradually increasing number of injuries attributable to the snubbing action of the seat belt itself. The case to be reported in this paper involves a young woman whose life was undoubtedly saved by a lap-type seat belt during a spectacular automobile accident. Approximately seven months later an unusual ventral hernia developed in the left upper quadrant of the abdomen, presumably caused by the snubbing action of the seat belt during the accident. This case is apparently unique, and possibly representative of a type of injury to be seen much more commonly in the future. <h3>Report of</h3>
Lixisenatide in Patients with Type 2 Diabetes and Acute Coronary Syndrome
Authors: Marc A. Pfeffer, Brian Claggett, Rafael Diaz, Kenneth Dickstein, Hertzel C. Gerstein, Lars V. Køber, Francesca C. Lawson, Lin Ping, Xiaodan Wei, Eldrin F. Lewis, Aldo P. Maggioni, John J.V. McMurray, Jeffrey L. Probstfield, Matthew C. Riddle, Scott D. Solomon, Jean-Claude Tardif
Journal: New England Journal of Medicine (2015)

Cardiovascular morbidity and mortality are higher among patients with type 2 diabetes, particularly those with concomitant cardiovascular diseases, than in most other populations. We assessed the effects of lixisenatide, a glucagon-like peptide 1–receptor agonist, on cardiovascular outcomes in patients with type 2 diabetes who had had a recent acute coronary event.
Lucky Lady
Authors: Eldad Ben-Chetrit
Journal: New England Journal of Medicine (1993)

A 24-year-old woman in the 21st week of her first pregnancy was admitted to the hospital with severe leg edema. Three years earlier, after arthritis and a facial rash had developed, a diagnosis of systemic lupus erythematosus had been made, and she had been treated with hydroxychloroquine. Laboratory tests at that time showed thrombocytopenia and anti-DNA antibodies. A year earlier the patient had had pure red-cell aplasia that was unresponsive to high-dose steroids but responsive to intravenous immune globulin. During the six months before conception she was receiving only prednisone (5 mg daily). She was asymptomatic until the 21st . . .
Fecal occult blood screening for colorectal cancer. Is mortality reduced by chance selection for screening colonoscopy?
Authors: C. A. Lang
Journal: JAMA (1994)

Annual fecal occult blood test (FOBT) screening using rehydrated Hemoccult slides has been reported in the Minnesota Colon Cancer Control Study to reduce colorectal cancer mortality by about 33%. However, some of the benefit of FOBT screening may come from "chance" selection of persons for colonoscopic examination because of the high positivity rate of FOBT (about 10%) that may occur for reasons other than a bleeding cancer or polyp. To determine how much this mechanism could account for the benefit of FOBT screening, we used a simple mathematical model to simulate the course of a cohort of screened persons, incorporating published data including those from the Minnesota study. The results suggest that one third to one half of the mortality reduction observed from FOBT screening in the Minnesota study may be attributable to chance selection for colonoscopy. We conclude that annual FOBT screening with rehydration is a haphazard method for selecting persons for colonoscopy. (<i>JAMA</i>. 1994;271:1011-1013)
SECTION REPRINTS.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Proceedings of the Connecticut Medical Society, 1883.
Journal: JAMA (1883)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Exposure Measurement Error in Time-Series Studies of Air Pollution: Concepts and Consequences
Authors: Scott L. Zeger, Duncan Thomas, Francesca Dominici, Jonathan M. Samet, Joel Schwartz, Douglas Dockery, Aaron Cohen
Journal: Environmental Health Perspectives (2000)

Misclassification of exposure is a well-recognized inherent limitation of epidemiologic studies of disease and the environment. For many agents of interest, exposures take place over time and in multiple locations; accurately estimating the relevant exposures for an individual participant in epidemiologic studies is often daunting, particularly within the limits set by feasibility, participant burden, and cost. Researchers have taken steps to deal with the consequences of measurement error by limiting the degree of error through a study's design, estimating the degree of error using a nested validation study, and by adjusting for measurement error in statistical analyses. In this paper, we address measurement error in observational studies of air pollution and health. Because measurement error may have substantial implications for interpreting epidemiologic studies on air pollution, particularly the time-series analyses, we developed a systematic conceptual formulation of the problem of measurement error in epidemiologic studies of air pollution and then considered the consequences within this formulation. When possible, we used available relevant data to make simple estimates of measurement error effects. This paper provides an overview of measurement errors in linear regression, distinguishing two extremes of a continuum-Berkson from classical type errors, and the univariate from the multivariate predictor case. We then propose one conceptual framework for the evaluation of measurement errors in the log-linear regression used for time-series studies of particulate air pollution and mortality and identify three main components of error. We present new simple analyses of data on exposures of particulate matter < 10 microm in aerodynamic diameter from the Particle Total Exposure Assessment Methodology Study. Finally, we summarize open questions regarding measurement error and suggest the kind of additional data necessary to address them.
'Normal'-pressure hydrocephalus and the saga of the treatable dementias
Authors: R. P. Friedland
Journal: JAMA (1989)

<h3>SELECTED CASE</h3> A 74-YEAR-OLD widow presented to the Laboratory of Neurosciences of the National Institute on Aging in February 1985 with a 4-year history of progressive cognitive impairment. She had experienced gradual onset of memory loss, with occasional urinary incontinence. There was no history of hypertension, cardiovascular disease, diabetes, head trauma, stroke, or intracranial bleeding or infection. She was not taking any medications. Social and family histories were not contributory. Findings from a general physical examination were normal. Neurological examination disclosed a mild dementia, with impaired memory, calculations, and constructions. Her score on the Mini-Mental State Examination<sup>1</sup>was 22 (23 to 30 is normal), and her score on the Blessed Memory and Information Concentration Test was 22 (normal score is 37).<sup>2</sup>She had poor balance but normal gait. Results from routine laboratory tests of blood and urine were normal, as was an electroencephalogram. Cerebrospinal fluid protein level, glucose
Polymorphism in Vitamin D-Binding Protein as a Genetic Risk Factor in the Pathogenesis of Endometriosis
Authors: Klaus Faserl, Georg Golderer, Leopold Kremser, Herbert Lindner, Bettina Sarg, Ludwig Wildt, Beata Seeber
Journal: Endocrine Reviews (2010)

Context Previous studies have implicated a deficiency in the inflammatory response in women who develop endometriosis. The specific immunological deficits have not been completely elucidated. Objective Our objective was to identify differences in protein expression in serum that might shed light on the pathophysiology of endometriosis. Design and Setting This cross-sectional study of women undergoing laparoscopy between 2003 and 2005 took place at a university medical center. Patients Patients included consenting women age 18-49 yr undergoing surgery for pain and/or infertility or elective tubal ligation. Women with acute or chronic medical conditions were excluded. Intervention Blood was collected preoperatively. Main Outcome Measure Proteomic analysis of serum was done using two-dimensional difference gel electrophoresis. Results We found 25 protein spots with a significant difference in abundance between women with endometriosis and controls, including acute-phase proteins and complement components. The abundance of vitamin D-binding protein was higher in all endometriosis pools by a factor of approximately 3 compared with the control pool (P &amp;lt; 0.02). Analysis of specific allele products using nano-LC-ESI-MS indicated that it was the GC*2 allele product that was in greater concentration in serum pools, as well as in single validation samples, in women with endometriosis (P = 0.006). In contrast to the GC*1 allele product, which is readily converted to a potent macrophage factor (Gc protein-derived macrophage-activating factor), the GC*2 allele product undergoes practically no such conversion. Conclusions We speculate that the inability to sufficiently activate macrophages’ phagocytotic function in those carrying the GC*2 polymorphism (more prevalent in endometriosis) may allow endometriotic tissues to implant in the peritoneal cavity. Future studies evaluating specific vitamin D-binding protein polymorphisms as a risk factor for endometriosis in larger populations of women are warranted.
Regular Exercise May Reduce Serum Triglyceride Levels
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Secondary Hyperparathyroidism
Authors: Mordecai M. Popovtzer
Journal: JAMA (1975)

In three patients with advanced renal disease (inulin clearance, 4.6 to 9.1 ml/min) and systemic manifestations of secondary hyperparathyroidism, concentrations of serum calcium and phosphorus were maintained within our normal limits (9 and 3.5 mg/100 ml, respectively) with phosphate-binding antacids and orally given calcium carbonate. The result was progressive disappearance of symptoms related to secondary hyperparathyroidism, healing of osteitis fibrosa, and normalization of serum concentrations of immunoreactive parathyroid hormone. (<i>JAMA</i>231:960-962, 1975)
A cost-effectiveness analysis of prophylaxis against deep-vein thrombosis in major orthopedic surgery
Authors: G. Oster
Journal: JAMA (1987)

A number of methods of prophylaxis can reduce the likelihood of postoperative deep-vein thrombosis in patients undergoing major orthopedic surgery. Using techniques of decision analysis, we examine the cost-effectiveness of several of these—warfarin sodium, low-dose subcutaneous heparin sodium, graduated compression stockings, intermittent pneumatic compression, heparin plus dihydroergotamine mesylate, and heparin plus stockings—compared with clinical diagnosis and treatment only. Our results show that 153 deaths per 10 000 patients occur when no prophylaxis is used; with most prophylaxes, this number is at least halved, and the most effective methods may reduce the number of deaths by three fourths. In addition, all of the prophylaxes considered are cost saving: average costs of care (including prophylaxis costs) are reduced by $19.40 to $181.60 per patient. Prophylaxis against deep-vein thrombosis in major orthopedic surgery therefore saves both lives and health care dollars. (<i>JAMA</i>1987;257:203-208)
Trauma, Disease, Compensation: A Handbook of Their Medico-Legal Relations.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Rectorragies: qui s’en plaint et que fait-on?
Journal: Endoscopy (2004)

Introduction: A l’heure des campagnes régionales de dépistage du cancer colorectal par hémoccult, la prévalence et les filières de prise en charge des saignements digestifs bas de la population française sont mal connues. L’objectif de cette étude était de les préciser à travers une enquête de sondage de type déclaratif. Patients et Méthodes: Un questionnaire auto administré de 31 questions a été adressé par voie postale à un échantillon représentatif de la population française (n = 10000 personnes de 15 ans et plus, 1217 hommes, 1699 femmes): 7196 questionnaires ont été retournés entre le 20 mai et le 26 juin 2003 et exploités après pondération (redressement: âge, sexe, PCS individu et lieu d’habitation). Résultats: Au cours des 12 derniers mois, 1358 personnes (18,9%) ont constaté au moins une fois la présence de sang lors de la défécation. Il s’agissait de la plainte proctologique la plus gênante pour 20,6% d’entre eux (n = 275): ils avaient plus de 35 et plus de 45 ans dans 67 et 42% des cas respectivement. Les saignements existaient depuis plus d’un an dans 72% des cas et depuis plus de 5 ans dans 32% des cas: ils n’ont jamais donné lieu à une demande de soin dans 56,3% des cas. Parmi les personnes qui ont consulté pour cette raison au cours des 12 derniers mois, 72% y ont eu recours dans les 6 mois qui ont suivi l’apparition des saignements. La démarche diagnostique a été entreprise dans le cadre de l’urgence dans 2% des cas. Chez les personnes qui ont consulté, aucune exploration n’a été proposée et/ou entreprise dans près de la moitié des cas. Un gastro-entérologue n’a été sollicité que dans moins d’un tiers des cas et une coloscopie n’a été réalisée qu’une fois sur quatre. Conclusion: Même lorsque les rectorragies sont jugées gênantes, le recours à une demande de soins et à des explorations diagnostiques est très insuffisant. A côté des campagnes de dépistage, une politique de sensibilisation de la population française est hautement souhaitable.
Book Review Radiologic Physics . By Charles Weyl, M.S.; S. Reid Warren, Jr., Sc.D.; and Dallett B. O'Neill. With a foreword by Eugene P. Pendergrass, M.D. 8°, cloth, 460 pp., with 166 illustrations and 33 tables. Springfield, Illinois: Charles C Thomas, 1941. $5.50.
Journal: New England Journal of Medicine (1941)
Lumen mapping: Pressure based algorithms to define intraluminal dimensions and physiologic characteristics in stenotic vessels Carlo Di Mario, Francesco Liistro, Antonio Colombo, Hylton Miller, Henri Noskowicz, Evgeny Shalman, Michael Simkhis. St. Raffaele Hospital, Milano, Italy, Tel Aviv Medical Center, Tel Aviv, Israel
Journal: Journal of the American College of Cardiology (2001)
Symposium on the Biochemical Cytology of Liver
Journal: JNCI Journal of the National Cancer Institute (1959)

Journal Article Symposium on the Biochemical Cytology of Liver Get access JNCI: Journal of the National Cancer Institute, Volume 22, Issue 1, January 1959, Page 205, https://doi.org/10.1093/jnci/22.1.205-a Published: 01 January 1959
Extravascular Albumin
Authors: Marcus A. Rothschild, Murray Oratz, Sidney S. Schreiber
Journal: New England Journal of Medicine (1979)

Albumin, the major secretory protein synthesized by the liver, is widely distributed throughout the body and is present in the vascular and extravascular volumes of all organs and tissues. In normal persons, approximately one third of the total exchangeable albumin mass is located within the plasma, and two thirds is in the extraplasma spaces.1 When albumin is injected into the plasma, it appears to enter interstitial compartments at two distinct rates, one relatively rapid and the other slow. The slow exchange probably occurs primarily in the interstitial space of skin and muscle, with the skin containing the largest fraction of . . .
Institution-wide accreditation and corporate responsibility
Authors: A. D. Hunt
Journal: JAMA (1970)

Accreditation of social institutions is a process by which the professions establish criteria, and apply them to the institutions under consideration so as to provide assurance that these institutions are meeting their goals and objectives in the interest of the society which they serve. In the case of institutions involved in the education of physicians, the accreditation process is perforce particularly stringent, in view of the life-and-death decisions entrusted by society to their products and of the extraordinarily sensitive and even dangerous nature of the therapeutic agents and technical ministrations available to them in the pursuance of their métier. Added to the burden of ensuring that citizens can entrust their lives to the graduates of our institutions is the burden of providing appropriate incentives to help institutions change so as to meet requirements and demands of a rapidly proliferating and changing society. The agencies with the responsibility of accrediting the