tbuckley/cabot-search huggingface dataset:
Calculators for overall survival (OS) and progression-free survival (PFS) in metastatic colorectal cancer (mCRC): Construction from 19,678 ARCAD patients.
Authors: Katrin Marie Sjoquist, Carsten Bokemeyer, Lindsay A. Renfro, John Simes, Niall C. Tebbutt, Stephen John Clarke, Richard Adams, Cornelis J. A. Punt, Eric Van Cutsem, Jean-Yves Douillard, J. Randolph Hecht, Volker Heinemann, Ioannis Sougklakos, Eduardo Diaz-Rubio, Rainer Porschen, Jeffrey P. Meyers, Wilson I. Gonsalves, Daniel J. Sargent, Aimery De Gramont, John Raymond Zalcberg
Journal: Journal of Clinical Oncology (2015)

3555 Background: Predicting survival in mCRC is difficult; even experienced oncologists can be inaccurate. Estimation of prognosis based on readily available clinicopathologic factors has the potential to inform clinical practice and aid in risk stratification for clinical trials. We constructed prognostic calculators for OS and PFS in mCRC using the multi-trial ARCAD database. Methods: 19,678 mCRC pts accrued to 24 randomized phase III clinical trials since 1997 used to construct and validate Cox models for PFS and OS, stratified on treatment arm within study. Candidate variables included age, sex, BMI, performance status, colon vs. rectal cancer, prior chemotherapy, number of metastatic sites, sites of metastases (liver, lung, lymph nodes), and baseline bilirubin, albumin, white blood cell count, hemoglobin, platelets, and absolute neutrophil count. Missing data ( < 11%) were imputed, continuous variables modeled with splines, and clinically relevant pairwise interactions considered if p < 0.001.Final models were internally validated (bootstrapping to obtain optimism-corrected calibration, discrimination C-indices) and externally validated using a 10% holdout sample from each trial. Results: Sex, liver, and lung metastases were not prognostic for OS; prior chemo, colon vs. rectum, liver and lymph node metastases, and sex did not predict PFS. No clinically relevant pairwise interactions were identified. Models for OS and PFS using remaining variables and were well calibrated with C-indices of 0.66 and 0.60, respectively. In external validation, concordance of predicted ( > vs. < 50% probability) and actual (yes/no) 1-year OS and 6-month PFS was 71% and 67%, respectively, and median 1-year OS and 6-month PFS predictions fell within the actual 95% Kaplan-Meier intervals. Work is ongoing to include molecular markers (BRAF, KRAS mutation); calculators will be updated to include these markers by the time of presentation. Conclusions: The proposed calculators are well calibrated and internally and externally valid. These tools have the potential to aid prognostication and patient/physician communication, and balance risk in randomized trials in mCRC.
The supply of primary care physicians
Authors: Steven R. Towner
Journal: JAMA (1991)

<h3>To the Editor.</h3> —Recently, much has been written about the paucity of young physicians entering primary care specialties. A recent article by Politzer et al<sup>1</sup>indicated that the primary emphasis for increasing physician supply ought to be at the level of medical education training. This analysis completely missed the main reason why more physicians have not entered primary care specialties. The reason is life-style. Three primary life-style factors that discourage more physicians from entering primary care include the following: (1) being on call; (2) finances; and (3) spouses. To elaborate, the on-call schedule of primary care physicians is, in most circumstances, far more rigorous than that for specialists. The type of work that is done on call is often performed for little financial reward. Second, the finances of primary care physicians are such that most can prolong their medical education from 8 to 9 or 10 years, counting medical
Medicine in the USA: historical vignettes. XV. Clinical science gets enthroned. Part I
Authors: L. S. King
Journal: JAMA (1983)

What we now call clinical science started to flourish vigorously in the early years of the 20th century. Within a brief decade or so several important institutions were founded, the attitudes of leading physicians began to change, and a new awareness and expectancy affected laymen. These various aspects helped to lay the foundation of clinical science, but they did not come into being suddenly. Rather, they were the culmination of a long preparation, comparable to the way a butterfly emerges after a long course of development. Earlier essays in this series described some of the specific events that reflected the changes of the 1880s and 1890s. We must now focus more precisely on the continuity out of which clinical science developed. The whole story falls within a frame of about 40 years, from approximately 1870 to 1910, give or take a few years at either end. Within this period a
Histopathological study of intrahepatic aberrant vessels in cases of noncirrhotic portal hypertension
Authors: M Ohbu
Journal: Hepatology (1994)

Aberrant vessels, which are defined as dilated blood vessels immediately adjacent to the peripheral portal tract, appear under conditions of extrahepatic portal obstruction and nodular regenerative hyperplasia as well as idiopathic portal hypertension. Our study was undertaken to compare their morphological aspects in these three disease cases. Aberrant vessels were found in 84% of cases of idiopathic portal hypertension, 67% of cases of extrahepatic portal obstruction infantile type, 78% of cases of extrahepatic portal obstruction adult type and 83% of cases of nodular regenerative hyperplasia. They were divided into three types: type I–no communication with the portal vein, the lumen of which is normally open; type II–communication with the portal vein; and type III–no communication with the portal vein, which is occluded. The most common types of aberrant vessel were type III in idiopathic portal hypertension (51%), type I in extrahepatic portal obstruction infantile type (46%), type II in extrahepatic portal obstruction adult type (43%) and type III in nodular regenerative hyperplasia (45%). Serial sections revealed transition between types I, II and III, at frequencies between types II and III, types I and II, and types I and III of 35.7%, 33.7% and 30.6%, respectively. Aberrant vessels demonstrated the same immunoreactivity as portal veins for collagen type IV, laminin, factor VIII and ulex europaeus agglutinin-I. They were concluded to arise from the vasa septalis or inlet venules, which would be used as intrahepatic shunts draining portal blood flow blocked by stenosed portal veins. Increased portal pressure would be expected to enhance development of aberrant vessels. They open into sinusoids, and differ from portovenous shunts, which are observed in liver cirrhosis. Therefore, the hepatic parenchyma is supplied with portal blood through aberrant vessels and thereby escapes from collapse induced by blockage of portal blood flow in spite of marked stenosis of peripheral portal veins in idiopathic portal hypertension. (Hepatology 1994;20:302–308.)
Ticks and disease.
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Female Gonadal Toxicities after Treatment of Primary Hodgkin Lymphoma (HL). Analysis of the LENT-SOMA Questionnaire Registered in the Database of the German Hodgkin Study Group (GHSG).
Authors: Karolin Behringer, Elena Gilman, Peter Borchmann, Eva Heuser, Beate Pfistner, Volker Diehl, Andreas Engert
Journal: Blood (2006)
Clouds on the 'private Medicare' horizon
Authors: B. R. Tresnowski
Journal: JAMA (1986)

IN THIS issue ofThe Journal, the American Medical Association's Council on Medical Service publishes a detailed description of a Board of Trustees-proposed conversion of the federal Medicare program to private insurers, at a rate that includes prefunding of benefits for future generations.<sup>1</sup>The goals of the program are ambitious: prefunded, affordable accessibility of comprehensive protection for an increasing cohort of the elderly in a system rationalized by means testing. The system would depend on the private market to underwrite the benefits, which are defined as "all services presently covered by Medicare Parts A and B, with additional benefits including periodic health examinations and other preventive services" and catastrophic expense "above a specified beneficiary cost sharing limit." Presumably there are statistics that would suggest the extent to which the proposed increase in the age of eligibility would limit liability, but this feature of the proposal may not go as
Pyridoxine-Responsive Anemia with Neuropathy
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Shifting Images: American News Photographs, 1861–1945
Authors: Brunet, François
Journal: Circulation (2017)

Shifting Images: American News Photographs, 1861–1945Thierry GervaisCirculationBetween the Civil War and World War II the illustrated press in America gradually came to use photography as a news medium. This major development in visual information was the outcome not simply of technical advances enabling recording of the visible with a minimum of human...AuthorThierry GervaisPublisherTerra Foundation for American ArtCopyright© 2017, Terra Foundation for American ArtRelated print edition pages: pp.78-111 https://doi.org/10.37862/aaeportal.00191.003 Stable URL: https://aaeportal.com/?id=-19913Copy Chapter subject tags:Documentary photography--United StatesPortrait photography--United StatesPhotojournalism
A Prospective, Randomized, Double-blind, Placebo-controlled Study of Orbital Radiotherapy for Graves’ Ophthalmopathy
Authors: Colum A. Gorman, James A. Garrity, Vahab Fatourechi, Rebecca S. Bahn, Ivy A. Petersen, Scott L. Stafford, John D. Earle, Glenn S. Forbes, Robert W. Kline, Erik J. Bergstralh, Kenneth P. Offord, Diana M. Rademacher, Nancy M. Stanley, George B. Bartley
Journal: Ophthalmology (2020)
The Uniform Anatomical Gift Act
Authors: P. A. Byrne
Journal: JAMA (1982)

<h3>To the Editor.—</h3> The Council on Scientific Affairs has addressed the issue of organ donor recruitment (1982; 246:2157). Reference is made to the Uniform Anatomical Gift Act (UAGA), which does not always involve "donation." The UAGA takes away the individual's right to refuse being an organ donor unless there is available an "actual notice of contrary indications by the decedent." In the absence of such actual notice, there is incorporated into the UAGA a descending order of classes of persons who may grant authority for use of "all or any part of the decedent's body," eventually reaching "any other person authorized or under obligation to dispose of the body." Furthermore, "the persons authorized... may make the gift after death or immediately before death." While the UAGA does not distinguish these two states, there is certainly a difference from the point of view of the defenseless individual. While the members of
Pasteurella Endocarditis
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Incorrect Legends
Journal: JAMA (1982)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
DOES LACTOSURIA OCCUR IN INFANCY?
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sexual Abuse
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
744 MANAGEMENT OF HYPOVASCULAR HEPATOCELLULAR NODULES SHOWING LOW SIGNAL INTENSITY IN THE HEPATOBILIARY PHASE OF GD-EOB-DTPA ENHANCED MRI
Authors: A. Sakamoto, R. Kita, E. Iguchi, S. Ako, Y. Koshikawa, T. Inuduka, H. Takeda, J. Nakajima, F. Matsuda, K. Hatamaru, S. Henmi, T. Ishikawa, S. Saito, H. Nishikawa, T. Kimura, Y. Osaki
Journal: Journal of Hepatology (2012)
Highlights
Journal: JAMA Psychiatry (2014)

Using postmortem human brain tissue, Konopaske and colleagues observe dendritic spine loss and reduced dendritic complexity in the dorsolateral prefrontal cortex from patients with schizophrenia and bipolar disorder.The dendritic spine loss in bipolar disorder is a novel finding and suggests that schizophrenia and bipolar disorder may share some important pathophysiological features.
Abstract LB-175: Genome-wide scan of the effect of cis-eSNPs on gastric cancer in Chinese population
Authors: Jing Ni, Jing Han, Meng Zhu, Guangfu Jin, Zhibin Hu
Journal: Cancer Research (2019)

Abstract Background: Previous genome-wide association studies (GWASs) have identified multiple single-nucleotide polymorphisms (SNPs) for gastric cancer risk. However, only a tiny fraction of heritability can be explained. Methods: We performed a comprehensive analysis to evaluate the associations between cis-expression quantitative trait SNPs (eSNPs) and susceptibility to gastric cancer in two GWAS datasets, including 2,631 gastric cancer cases and 4,373 controls. Gene-based and pathway analysis were conducted by the sequence kernel association test (SKAT-C) and the adaptive rank truncated product (ARTP) method, respectively. Results: A total of 314,518 eSNPs were remained after quality control, which mapped to 5,155 genes and 1,077 pathways. We identified six novel eQTL SNPs in unknown loci which can explain approximately 3.56% of the phenotypic variances combined with known GWAS related variants. Function analysis revealed that rs3129206 might affect the susceptibility of gastric cancer via regulating the expression of HSD17B8, while rs6930376 regulating the expression of PSORS1C3. Pathway-based analysis showed a total of seven potential pathways might account for the risk of gastric cancer (Pfdr&amp;lt;0.1). Conclusion: Our findings demonstrate an overview of the associations between eSNPs and gastric cancer risk in Chinese population, which provide insight into genes and pathways that may be biologically relevant for risk of gastric cancer. Citation Format: Jing Ni, Jing Han, Meng Zhu, Guangfu Jin, Zhibin Hu. Genome-wide scan of the effect of cis-eSNPs on gastric cancer in Chinese population [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr LB-175.
Migraine
Authors: E. Anne MacGregor
Journal: Annals of Internal Medicine (2017)

This issue provides a clinical overview of migraine, focusing on risk, prevention, diagnosis, treatment, follow-up, and practice improvement. The content of In the Clinic is drawn from the clinical information and education resources of the American College of Physicians (ACP), including MKSAP (Medical Knowledge and Self-Assessment Program). Annals of Internal Medicine editors develop In the Clinic in collaboration with the ACP's Medical Education and Publishing divisions and with the assistance of additional science writers and physician writers.
THE PATHOLOGIC EXHIBIT AT ATLANTIC CITY
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Educational Number: Corrections
Journal: BMJ (1899)

Aspiration of the joint, followed by firm pressure obtained by wool pads, and a bandage, and the fitting of a "calliper" Thomas's knee splint so that the patient can get about, is often a successful, measure in such a case.Incision and washing out has been practised, but there is often a tendency to recurrence alter this operation, though many cases are reported as cured.SALINE INJECTIONS IN COLLAPSE.E. D.