tbuckley/cabot-search huggingface dataset:
Radiation as primary treatment for local control of breast carcinoma. A progress report
Authors: E. Weber
Journal: JAMA (1975)

One hundred patients with localized breast carcinoma have been treated by radiation alone from July 1,1968, until June 30,1973, at the Joint Center for Radiation Therapy. Patients were referred for many reasons, including changing opinions as to the indications for mastectomy. External beam therapy to the tumor bearing volume and its regional nodal chains has been frequently supplemented by iridium 192 interstitial implantation. Local control has been excellent, particularly in early stage disease. Regionally advanced mammary carcinoma, despite apparently adequate local therapy, demonstrates a rapidly falling survival curve, suggesting the need for early systemic chemotherapy. (<i>JAMA</i>234:608-611, 1975)
Ventricular Tachycardia
Authors: Julius L. Bedynek
Journal: JAMA (1966)

EXTERNAL direct-current and alternating-current countershock has proved effective in terminating ventricular tachycardia. Various medications have also been used to control this arrhythmia. This paper describes the successful use of frequent intermittent, intravenous administration of lidocaine (Xylocaine) hydrochloride to control recurrent ventricular tachycardia after the failure of other commonly available drugs. <h3>Report of a Case</h3> A 31-year-old white woman was admitted to the hospital for elective pelvic surgery. There was a history of eight normal full-term deliveries, two spontaneous abortions, and dilation and curettage had been done five times. She had had two brief episodes of palpitations, 13 and 9 months previously. Evaluation after the latter episode revealed an innocent cardiac murmur. On this admission a grade II (of VI), basal, systolic ejection murmur was heard and considered to be innocent. Results of urinalysis and serological study were normal, and a hemogram and chest roentgenogram were normal. An electrocardiogram was not
Mental Health and Split-Level Thinking
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The role of medicine within a business organization
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Incorrect Company Name
Authors: Gary Plotnick, Mary Corretti, Robert Vogel
Journal: JAMA (1998)

cholesterol lowering, 5 large randomized trials have now shown 24% to 36% reductions in major cardiovascular events. 3 This clinical significance was predicted, but not proven, by the mechanistic angiographic trials.In our case, 2 recent articles have confirmed that short-term fat intake impairs endothelial function and increases blood coagulability. 4,5The observed magnitude of changes in the intermediate biological outcomes studied was similar to our findings.The clinical significance of these findings on the vascular biology of fat and antioxidant vitamin intake awaits clinical trials with appropriate end points generated from these statistically significant and interesting observations.
Correction
Journal: BMJ (1965)

should be some attempt to signpost these routes.Defining techniques need not mean "splitting hairs."The weakness of the term "therapeutic community " is that it so readily means all things to all psychiatrists.All communities intra-communicate.Many pro- mote mental health.Presumably what distinguishes the " thera- peutic community " from other communities is that it is psychotherapeutic.Historically this psychotherapy has had some links with psycho-analysis.Group communication based on analytic technique differs fundamentally in kind from that described by Dr. Mary Lightbody and Dr. S. Jacobson (2 January, p. 47).Either may or may not be therapeutic-this
Comprehensive genomic profiles of metastatic and relapsed salivary gland carcinomas are associated with tumor type and reveal new routes to targeted therapies
Authors: L.M. Gay, J.S. Ross, K. Wang, J.-A. Vergilio, J. Suh, S. Ramkissoon, D. Bowles, H. Serracino, J. Russell, S. Ali, V. Miller, P. Stephens, J.A. Elvin
Journal: Annals of Oncology (2016)
THE SO-CALLED BICHLORIDE OF GOLD TREATMENT FOR INEBRIETY.
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The earliest roentgenographic signs of carcinoma of the lung
Authors: L. G. Rigler
Journal: JAMA (1966)

Despite the more general use of sputum cytology and bronchoscopy, the most available, least expensive, and simplest method for the detection of a malignant lesion in the lung, when it is small, is roentgen examination.<sup>4</sup>A single posteroanterior roentgenogram made in inspiration is an effective method for finding cases in their presymptomatic stage. An additional number of small lesions would be discovered if it were possible to add a second film so that stereoscopic or posteroanterior and lateral views would be made in each case. Obviously, additional roentgenograms, such as those made in the oblique positions, apical lordosis, and in expiration would increase the productivity, but it is impractical to make such elaborate examinations in asymptomatic individuals. The presence of symptoms which are at all suggestive of carcinoma of the lung should lead to such a thorough investigation, to which should be added body-section roentgenography and, if needed, bronchography.
National survey of tuberculosis notifications in England and Wales 1978--9. Report from the Medical Research Council Tuberculosis and Chest Diseases Unit.
Authors: J Nunn, Naznin Bhimji, Janet Darby- Shire, K Citron
Journal: BMJ (1980)

A survey of all tuberculosis notifications in England and Wales for a six-month period showed that 70% of 3732 newly notified, previously untreated patients had respiratory disease only, 23% had non-respiratory disease only, and 7% had both. Fifty-seven per cent of patients were of white and 35% were of Indian subcontinent (Indian, Pakistani, or Bangladeshi) ethnic origin, the latter group contributing over half the cases of non-respiratory disease. The estimated overall annual notification rate per 100 000 population for 1978--9 was 16.4 for England and 13.5 for Wales. The rates differed considerably between the different ethnic groups in England, the highest rates occurring in the Indian and in the Pakistani and Bangladeshi groups and the lowest in the white group; the differences in the non-respiratory rates were the more striking. Nearly a quarter of patients with respiratory disease had large pulmonary lesions, the proportion being higher for the white group than for the Indian subcontinent group. Over half the patients had positive cultures for tubercle bacilli and over a third had positive smears; both proportions were higher for the white group. This survey has identified many of the problems which tuberculosis presents in England and Wales today. These include the substantial number of patients with sputum-positive disease, the considerable variation in the rates in the different ethnic groups, and the not uncommon occurrence of childhood tuberculosis.
ETIOLOGY OF GENERAL PARALYSIS OF THE INSANE.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Growth and Metastasis of Tumor In Organ Culture
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 4355: Altered acetate metabolism in cisplatin resistant bladder cancer
Authors: Jayoung Kim
Journal: Cancer Research (2019)

Abstract Introduction and Objective: Cisplatin is an important chemotherapeutic agent against metastatic bladder cancer, but resistance often limits its usage. With the recent recognition of lipid metabolic alterations in bladder cancers, we studied the metabolic implications of cisplatin resistance using cisplatin-sensitive (T24S) and resistant (T24R) bladder cancer cells. Methods: To test whether there should be differences in metabolism and metabolism-associated pathways between cisplatin-sensitive and resistant bladder cancer cells, we applied the live metabolomics approach that we recently developed to isogenic bladder cancer cell lines T24S (cisplatin sensitive) and T24R (cisplatin resistant). The metabolites generated from 13C-glucose tracer were monitored with 2D 1H-13C HSQC NMR in real time. Results: Real-time live metabolomics revealed that T24R cells consume more glucose, leading to higher production of glucose-derived acetate and fatty acids. Along with the activation of general metabolic regulators, enzymes involved in acetate usage (ACSS2) and fatty acid synthesis (ACC) and a precursor for fatty acid synthesis (acetyl-CoA) were elevated in T24R cells. Consistently, metabolic analysis with 13C isotope revealed that T24R cells preferred glucose to acetate as the exogenous carbon source for the increased fatty acid synthesis, contrary to T24S cells. In addition, ACSS2, rather than the well-established ACLY, was the key enzyme that supplies acetyl-CoA in T24R cells through glucose-derived endogenous acetate. The relevance of ACSS2 in cisplatin resistance was further confirmed by the abrogation of resistance by an ACSS2 inhibitor and, finally, by the higher expression of ACSS2 in the patient tissues with cisplatin resistance. Conclusions: Our results may help improve the treatment options for chemoresistant bladder cancer patients and provide possible vulnerability targets to overcome the resistance. Citation Format: Jayoung Kim. Altered acetate metabolism in cisplatin resistant bladder cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4355.
Prospective study of human parvovirus (B19) infection in pregnancy. Public Health Laboratory Service Working Party on Fifth Disease.
Authors: Richard Doll, Elisabeth Cardis, Sarah Darby, Ichiro Kawachi
Journal: BMJ (1990)

To determine the fetal infection rate and outcome of pregnancy among women who acquire infection with human parvovirus (B19) in the antenatal period.Prospective study of infected pregnancies till time of delivery or abortion with virological investigation of fetuses, neonates, and 1 year old infants.England and Wales during 1985-8.190 Pregnant women with serologically confirmed B19 infection in pregnancy, their fetuses, neonates, and 1 year old infants.Of 186 mothers who elected to go to term, 156 (84%) delivered a normal baby. Follow up of 114 of these infants to the age of 1 year disclosed no appreciable abnormalities, although 27 had serological evidence of intrauterine infection. The overall fetal loss rate (30 cases; 16%) was similar to that in an uninfected antenatal sample (unmatched), but there was a pronounced excess of fetal loss in the second trimester in the B19 infected mothers (11.8%; 95% confidence interval 6.8% to 17.8%). Based on virological findings in the aborted fetuses the risk of fetal death due to B19 in an infected pregnancy was estimated to be 9%. The transplacental transmission rate was estimated to be 33%.Most women with B19 infection in pregnancy had a satisfactory outcome, but there was nevertheless a substantial risk of fetal loss in the second trimester. In view of the absence to date of any evidence of damage to babies who survive maternal infection therapeutic termination of pregnancy is not indicated.
Calcium-Mediated Mechanisms In Chemically Induced Cell Death
Authors: P Nicotera
Journal: The Annual Review of Pharmacology and Toxicology (1992)

Over the past two decades, deadly coronaviruses, with the most recent being the severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) 2019 pandemic, have majorly challenged public health. The path for virus invasion into humans and other ...Read More
In Reply
Authors: Philippe Morice, Catherine Uzan, Enrica Bentivegna, Sebastien Gouy, Sophie Leboulleux, Martin Schlumberger, Christine Haie-Meder
Journal: Journal of Clinical Oncology (2008)

We read the article by Boughanim et al 1 with great interest.The authors observed that 8% of patients (three of 38 patients) with stage IB/II cervical cancer who had no evidence of para-aortic node metastasis on their pretreatment positron emission tomography/computed tomography (PET/CT) scan actually had para-aortic nodal metastasis at the time of surgery.In the study, one of the suggested explanations for the nonvisualization of positive paraaortic nodes was the metastasis during the interval between PET/CT scan and the lymphadenectomy.][4] Between October 2003 and January 2006, 27 patients with stage IB-IVA squamous cell cervical carcinoma were enrolled.Twenty-four patients (88.9%) had no evidence of para-aortic node involvement at PET/CT scan.The median age was 49 years (range, 26 to 67 years), and the distribution of International Federation of Gynecology and Obstetrics stage was as follows: IB2 (n ϭ 1), IIA (n ϭ 1), IIB (n ϭ 19), and IIIA (n ϭ 3).After laparoscopic staging, two patients (8.3%) were shown to have para-aortic node metastasis.Although we performed surgical staging before treatment, the frequency of falsenegative PET/CT scan was strikingly similar to the data provided by Boughanim et al. 1 Moreover, two recently published studies reported that para-aortic lymph node assessment by PET/CT had false negativity rates from 4.3% (one of 23) to 16.7% (two of 12). 5,6The pooled analysis of the three studies 2,5,6 suggests that negative para-aortic status assessed by PET/CT has a false-negative rate of 8.5% (95% CI, 3.2% to 19.4%).Therefore, it is more likely that para-aortic node assessment by PET/CT has innate false negativity.If correct, this notion raises an important concern regarding the role of concurrent chemotherapy.If the false-negative rate of PET/CT for para-aortic nodal status does not differ pre-and post-treatment, it would suggest that concurrent chemotherapy has little role in eradicating occult para-aortic nodal metastasis without extended-field ra-
Buoyant density of hepatitis C virus recovered from infected hosts: Two different features in sucrose equilibrium density-gradient centrifugation related to degree of liver inflammation
Authors: T Kanto
Journal: Hepatology (1994)

Hepatitis C virus is reported to have a low buoyant density in sucrose. To determine the density of hepatitis C virus in the circulation of infected hosts and its association with the degree of liver inflammation, we examined serum samples from 10 patients who were positive for both hepatitis C virus antibody (C100 antigen) antibody and serum hepatitis C virus RNA. After the serum was ultracentrifuged in sucrose density gradient (10 to 60), the hepatitis C virus RNA titer in each collected fraction was quantified by means of competitive reverse transcription–polymerase chain reaction. In samples from five blood donors, the hepatitis C virus RNA titer had a single peak at fractions with densities of 1.08 to 1.11 gm/ml. In samples from five patients with ALT abnormalities, the titer had two peaks at fractions with 1.09 to 1.10 gm/ml and 1.22 to 1.25 gm/ml. After the selected samples were treated with detergents and ultracentrifuged, the titer in the 1.08 to 1.11 gm/ml fractions decreased and that in the 1.22 to 1.25 gm fractions increased. This result implied that the hepatitis C virus density changed with removal of the viral envelope by lipid solvents. Thus the buoyant density of hepatitis C virus in sucrose was 1.08 to 1.11 gm/ml for an intact virion and 1.22 to 1.25 gm/ml for what was presumed to be a nucleocapsid. These results demonstrated that HCV virion is a dominant form in the circulation of blood donors without ALT abnormalities. In patients with liver inflammation HCV particles with higher densities of 1.22 to 1.25 gm/ml coexist with virion in the circulation, which might be presumed nucleocapsids. (Hepatology 1994;19:296–302).
Fatal nonbacterial pneumonia associated with Adenovirus type 4. Occurrence in an adult
Authors: S. Levin
Journal: JAMA (1967)

Fatal nonbacterial pneumonia occurred in a previously healthy young adult. Epidemiological, virological, and pathological studies suggest an etiological relationship between adenovirus type 4 isolation and this fatal pneumonia. This is the first such relationship in a previously healthy adult which has been reported to our knowledge.
Plain Language Summaries
Journal: British Journal of Dermatology (2015)

Basal cell carcinoma (BCC) is the most common type of skin cancer and has a number of different sub-types.The thickness of the tumour, meaning how far it goes down into the skin from the surface, helps doctors to decide on the best treatment.For thinner tumours, topical treatments may be used, such as creams applied to the skin.However, the depth of the tumour is not always easy to establish just by examining it with the naked eye (known as a clinical examination), and at present, biopsy to provide a sample for histopathological evaluation (under a microscope) of the tumour thickness is considered the 'gold standard'.Even so, BCC is sometimes treated without histopathological investigation of its thickness.This study, from Norway, used data from 159 BCC thickness measurements to compare clinical with histopathological results, thereby to evaluate whether the clinical assessment of tumour thickness is accurate.The authors found that for tumours of approximately 1Á6 mm thickness, the clinical and histological results agreed.However, clinical examination overestimated the thickness of tumours thinner than approximately 1Á6 mm, and underestimated the thickness of thicker tumours.The authors conclude that these results suggest that biopsy for histopathological measurement of tumour thickness should occur, before doctors decide to use topical therapy.Hidradenitis suppurativa and metabolic syndrome: a comparative cross-sectional study of 3207 patients