tbuckley/cabot-search huggingface dataset:
Nautical Medicine
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Two Lectures on Tumours of the Larynx; Their Pathology, Symptoms, and Treatment, with Illustrative Cases
Authors: D. Newman
Journal: BMJ (1886)

forehead, and with both feet.A current of fourteen volts was passed for half an hour.The resistance was found to be 600 ohms, rising to 680, and, when corrected by Mance's method, 543 ohms.Of this, 137 ohms were due to polarisation.The third had also had diabetes, and a current of 10 volts was passed in the same way.The resistance was found to be 1,100 ohms, rising to 1,160, and, when corrected by Mance's method, 1,025 ohms.Polarisation was equal to 145 ohms, a larger electromotive force than had been before demonstrated.Dr. Stone then gave a very excellent measurement, made independenitly of himself, and which is represented by two curves on the diagram.The first part of the curve below the line in the middle is the period of charge.All the measurements are given.Then the discharge takes place where the vertical line is.The galvanometer shoots up to the point C, and comes down again, but not to the line ,of zero.On the contrary, it remains steadily, and for a very con- siderable time-very much longer than be anticipated-discharging through the galvanometer without losing its charge.In that case, there are tenl iminutes given, and the fall in the current is very slight.In many cases, he had been able to produce a much larger effect than that.It was iintentionally taken with a small current, so that we should be able to rmeasure it with a delicate galvanometer.The Initial T'hrow.-As to the great initial throw, it could not be said, without experiment, how much of this was due to the needle swinging under its owii inertia.This poinat had been de- termined, at Dr. Stone's request, by Mr. Wilkinson, Mr. Lant Car- penter's assistant.An experiment was made under exactly the same conditions, but with an inert instead of a polarisable resistance, and the permanent deflection reproduced.The throw, under these con- (litions, did not reach the point of discharge given from the body.The difference between the two was due to the effect of self-induction it was exceedingly small in the experiment, because the electro- motive force used was very low-about two volts, compared with the ele-tromotive force of the body, which was about one volt.It was difficult to separate polarisation from capacity, but this experiment showed that there was some self-induction.The discharge from the patient observed in Messrs. Lant Carpenter and Wilkinson's experiment, referred to in the first lecture (see page 729), when no battery was in circuit, was 60 micro-amperes.After three minutes, it fell to 48.7 micro-amp6res, and, after two minutes more, to 45 micro-amperes.The body, therefore, had discharged itself like a secondary battery.
Haven
Authors: Timothy Lahey
Journal: Annals of Internal Medicine (2002)

Ad Libitum5 November 2002HavenTimothy Lahey, MDTimothy Lahey, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-137-5_Part_1-200209030-00013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail I drive in,pelted by hail.Each impact feels like a curse,a bitter recollectionof our minor atrocities,our inability to be concerned.After I park, and run,my white coat gets wet,and weighs heavier by the second.Entering, I await the moment thatthe beeping and whirring inside,disguise the staccato rebukeof the storm outside.the ... Author, Article, and Disclosure InformationAffiliations: Current Author Address: Timothy Lahey, MD, Beth Israel Deaconess Medical Center, One Autumn Street, Kennedy-6, Boston, MA 02215 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 5 November 2002Volume 137, Issue 9Page: 767KeywordsIntensive care unitsNursesStormsTrachea ePublished: 5 November 2002 Issue Published: 5 November 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Abstract AS20: DNA-PKcs is amplified in high grade serous ovarian cancer (HGSC), correlates with poor outcome and drives resistance to platinum therapy via the AKT signaling pathway
Authors: E Curry, A Cheraghchi-Bashi-Astaneh, M Chen, P Cunnea, C De Sousa, E Maginn, Y Dai, E Liu, H Wasan, G Mills, D Bowtell, H Gabra, EA Stronach
Journal: Clinical Cancer Research (2015)

Abstract High grade serous ovarian cancer is typified by p53 mutation, high degrees of genomic instability and the development of chemo-resistance. Genomic translocations result from incorrectly repaired DNA double strand breaks (DSBs). DNA-PKcs is a central catalytic component of the error prone non-homologous end joining (NHEJ) DSB repair mechanism. We report here that DNA-PKcs is frequently amplified in copy number in HGSC and that amplification correlates with higher DNA-PKcs gene expression and poorer patient outcome (PFS/OS) using both in-house and publicly available datasets (TCGA). Targeting DNA-PKcs, pharmacologically or by RNAi, enhances apoptosis in response to platinum treatment in platinum resistant cell lines and primary models. Furthermore we report that inhibition of DNA-PK restores response to cisplatin in chemoresistant ovarian cancer cells in vivo. SKOV-3 tumor xenografts were implanted subcutaneously into Balb/c Nu/Nu mice and treated with DNA-PKcs inhibitor NU7441 for 2 weeks alone or in combination with cisplatin. DNA-PK inhibition or cisplatin treatment alone were ineffective however in combination they decreased tumor growth at 14 days by 90%, relative to platinum only treatment. On investigating the mechanism of DNA-PKcs mediated chemoresistance we revealed that, in response to DNA damage, DNA-PKcs phosphorylates AKT on serine residue 473 in the nucleus of platinum resistant ovarian tumor cells, but not sensitive cells from the same patient. Phosphorylation at AKT threonine 308 is unaffected and DNA-PK inhibition does not interfere with insulin-mediated phosphorylation of AKT S473. DNA-PK mediated AKT activation in chemoresistant cells results in inhibitory phosphorylation of the pro-apoptotic protein BAD and stabilisation of the anti-apoptotic Bcl-2 protein resulting in the observed attenuation of apoptotic response to platinum treatment. DNA-PK inhibition is an attractive therapeutic strategy for resensitising resistant tumors to platinum based therapy, directly linking the DNA damage caused by platinum to the pro-survival AKT pathway, without interfering with normal physiological roles of AKT. Citation Format: Curry E, Cheraghchi-Bashi-Astaneh A, Chen M, Cunnea P, De Sousa C, Maginn E, Dai Y, Liu E, Wasan H, Mills G, Bowtell D, Gabra H &amp; Stronach EA. DNA-PKcs is amplified in high grade serous ovarian cancer (HGSC), correlates with poor outcome and drives resistance to platinum therapy via the AKT signaling pathway [abstract]. In: Proceedings of the 10th Biennial Ovarian Cancer Research Symposium; Sep 8-9, 2014; Seattle, WA. Philadelphia (PA): AACR; Clin Cancer Res 2015;21(16 Suppl):Abstract nr AS20.
Biliary tract
Authors: D Conte, M Barisani, P Fraquelli, P Casarinl, M Bodini2, G Borzio3, C Aimo4
Journal: Gut (1993)

Background Several studies have described an increased prevalence of gallstones (GS) in cirrhosis; furthernore, an annual incidence of 2.6% (1) and a global cumulative incidence of 5.5 cases/100 patients/year have recently (2) been reported.Aim To estimate the probability of GS development and related risk factors in 400 patients with cirrhosis of different etiology, GS free at enrollment.Patients 400 patients (257 men and 143 women; mean age 58 ± SD 10 yr, and 61 + SD 10 yr., respectively) with cirrhosis related to alcohol abuse (n=169), HBV or HCV chronic infection (n=138), HBV or HCV chronic infection and alcohol abuse (n=50) and -niscellanTus; (n=4-3>)-At enrollment 231 patients were in Child's A class, 130 in B and 39 in C. Follow up consisted of clinical examination, liver function test and ultrasound liver scan (US) every six months.Diagnosis of GS was based on consistent US findings or emergency cholecystectomyfor GS.Methods The cumulative probability of developing GS was estimated by the Kaplan-Meier method.Possible risk factors for GS were studied by logistic regression analysis which included the following variables: sex, age, body mass index (BMI), alcohol intake, Child's class, etiology of cirrhosis, HBsAg, albumin, bilirubin, AST, ALT, yGT, alkaline phosphatase, cholesterol,
The 'slippery slope': handling HIV-infected health workers
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 3668: Endothelial Progenitor Cells Express Connexins which may be Important for the Functional Integration of Circulating Progenitor Cells into the Endothelium
Authors: Vasileios Petoumenos, Georg Nickenig, Nikos Werner
Journal: Circulation (2008)

Bone marrow (BM)-derived endothelial progenitor cells (EPC) enhance endothelial cell (EC) repair after focal EC damage, improve endothelial dysfunction, and are an important cellular risk predictor for cardiovascular mortality. For an effective EC repair, functional integration of circulating EPC into the damaged endothelium is a pre-requisite. Here, we determine the importance of connexins (Cx) for the interaction with mature ECs. Expression of Cx was evaluated on magnetic-bead selected CD133+ cells using immunocytochemistry and flow cytometry. CD133+ cells expressed Cx 40 and Cx 43 but not Cx 37. Mononuclear cells were cultivated to obtain early outgrowth EPC or colony forming units-endothelial cells (CFU-EC). Cx 37, 40, and 43 were expressed on cultured EPC. Co-culture experiments with mature human coronary artery endothelial cells (HCAEC) and EPC demonstrated the development of Cx 40, and 43 positive gap-junctions between both cells types. In order to investigate whether the interaction between HCAEC and EPC results in a functional communication between cells, dye transfer experiments were performed. Di-Ac-LDL labelled EPC transformed into Di-Ac-LDL and Calcein AM double positive cells when co-cultured with Calcein AM positive HCAEC and vice versa. In order to study the role of connexins in reendothelialization, C57bl6 (wild-type, WT) mice were subjected to a focal endothelial cell denudation and repetitively treated with WT and Cx37−/− deficient mononuclear cells. In contrast to the treatment with WT mononuclear cells, treatment with Cx37−/− cells was not associated with enhanced reendothelialization. Furthermore, endothelial function of isolated aortic rings derived from Cx37−/− mice showed an impaired endothelial-dependent vasorelaxation compared to WT mice. We provide evidence that connexins are differentially expressed on immature naíve EPC and cultured early-outgrowth EPC. The expression of connexin 37, 40, and 43 may be required for the functional integration of endothelial progenitor cells into the damaged endothelium.
The management of cancer metastatic to bone
Authors: A. D. Aaron
Journal: JAMA (1994)

<h3>SELECTED CASE</h3> A 61-year-old woman with a 4-year history of breast cancer and known metastatic bone disease presented with bilateral hip pain for 3 months. Roentgenograms of the left hip revealed a destructive lesion involving the inter-trochanteric region of the left proximal femur. The left femoral lesion measured approximately 2 by 3 cm and involved 60% of the cortex. Right hip roentgenograms demonstrated an acetabular lesion of unknown extent. Bone scan revealed no other lesions. The patient subsequently underwent irradiation of both hips with excellent pain relief on the left but continued symptoms on the right. Orthopedic consultation was requested to evaluate the patient's risk for pathological fracture on the left. Computed tomography (CT) of the pelvis demonstrated a pathological fracture of the right acetabulum. Since the patient was free of pain on the left hip, a cemented total-hip arthroplasty was performed on the right hip. The patient did well
Barriers to hepatitis C virus elimination in Germany: why aren’t diagnosed patients initiating therapy?
Authors: Peter Buggisch, Hans Heiken, Stefan Mauss, Bernd Weber, Maria-Christina Jung, Herbert Görne, Renate Heyne, Holger Hinrichsen, Dennis Hidde, Bettina König, Ana Gabriela Pires dos Santos, Claus Niederau, Heiner Wedemeyer, Thomas Berg
Journal: Journal of Hepatology (2020)
Diagnostic accuracy of liver stiffness measurement by fibroscan in liver transplant recipients
Authors: Zeynep Melekoğlu Ellik, Aysun Caliskan, Serkan Duman, Mesut Gümüşsoy, Abdullah Mübin Özercan, Ramazan Erdem Er, Atilla Halil Elhan, Ramazan Idilman
Journal: Journal of Hepatology (2020)
Traffic death toll may be declining, but experts not ready to celebrate
Authors: C. Marwick
Journal: JAMA (1992)

TRAFFIC FATALITIES in the United States for the past year appear to total about 41 150. That is a preliminary figure, subject to change with the arrival of late reports and further analysis. But, tragic as each death is, an annual toll of approximately that number would be the lowest in recent years. What is more, some experts predict this trend will continue amid the nation's traffic violence. At a national meeting of the Automotive Safety Foundation in Washington, DC, recently, leaders in highway traffic and safety set what they held were reasonable goals: reducing the annual traffic deaths to no more than 35 500 by 1995 and again to 26 000 by the year 2000. The National Highway Traffic Safety Administration reports that in 1990 there were 44 529 fatalities on the nation's highways. <h3>Lowest and Highest</h3> This compares with 42 583 deaths in 1983; and 51 093 deaths
Catalogo dell Officina Ortopedica dell Istituto Rizzoli in Bologna.
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The challenge of medicine in the '70s. Health care through education
Authors: C. P. Kimball
Journal: JAMA (1971)

Make no little plans. They have no magic to stir men's blood and probably themselves will not be realized. Make big plans. Aim high in hope and work, remembering that a noble, logical diagram once recorded will never die, but long after we are gone will be a living thing, asserting itself with ever-growing insistence. Remember that our sons and grandsons are going to do things that would stagger us. Let your watchword be order and your beacon beauty. Think big. Daniel Burnham, Pioneer Chicago Architect and City Planner
A Correction
Journal: BMJ (1896)

LM2zC" 1237 accompanying sketch showing the faults of other syringes.rn this illustration the gonorrhceal matter should be observed pushed back down the urethra by the imperforate bulb, and the injection fluid flying in the opposite direction, retiring as it were before the enemy, leaving the gonococci masters of the situation.In the first illustration the gonorrheeal matter
Commercial Fishing Fatalities—California, Oregon, and Washington, 2000-2006
Journal: JAMA (2008)

During 2000-2006, commercial fishing was one of the most dangerous occupations in the United States, with an average annual fatality rate of 115 deaths per 100,000 fishermen. By contrast, the average annual occupational fatality rate among all U.S. workers during the same period was four deaths per 100,000 workers. During the 1990s, safety interventions in Alaska fisheries were followed by declines in that state's commercial fishing fatality rates. To assess the need for similar safety improvements in the other three Pacific Coast states, CDC analyzed data on commercial fishing fatalities from California, Oregon, and Washington during 2000-2006. The results of that analysis indicated that the three states combined had an average annual commercial fishing fatality rate of 238 deaths per 100,000 full-time equivalent (FTE) fishermen, approximately double the fishing fatality rate nationwide during the same period. CDC also determined that safety equipment (e.g., immersion suits or life rafts) had not been used adequately in these fatal events, and that the Northwest Dungeness crab fishery had the highest fatality rate of any fishery located off the coasts of California, Oregon, and Washington. To reduce fatalities among the Pacific Coast commercial fishermen at greatest risk, additional prevention measures tailored to the Northwest Dungeness crab fishery should be considered.
Women's Health in <i>Circulation</i> and the <i>Circulation</i> Subspecialty Journals
Journal: Circulation (2012)

The following articles are being highlighted as part of Circulation's Topic Review series. This series will summarize the most important manuscripts, as selected by the editors, published in Circulation and the Circulation subspecialty journals. The studies included in this article represent the articles related to women's health that were published in Circulation and the Circulation subspecialty journals in 2010 and 2011.
Fortification of flour and bread with iron
Journal: JAMA (1973)

<h3>To the Editor.—</h3> An editorial from the AMA Council on Foods and Nutrition<sup>1</sup>reflects a softening of official posture in the matter of fortification of bread with additional iron. The weight of the Council has been thrown repeatedly in favor of a Food and Drug Administration (FDA) proposal that requires that the iron in enriched flour and bread be increased by some 300%. Prior to the recent editorial, the matter of hazard from excess iron was ignored in the planning and belittled in the defense of this unfortunate proposal.<sup>2-4</sup>Now the Council concedes that a "potential hazard" exists. "The Council appreciates, also, that factual information concerning both the beneficial and possible harmful effects of this fortification is limited and that very little research has been carried out in this area during the past two years when fortification has been under discussion." The Council now calls for research into
Pulse THE MEDICAL STUDENT SUPPLEMENT OF JAMA
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
&lt;TITLE&gt;Lymphoma&lt;/TITLE&gt;
Journal: JAMA (2001)

information and recommendations appearing on this page are appropriate in most instances, but they are not a substitute for medical diagnosis.For specific information concerning your personal medical condition, JAMA and the AMA suggest that you consult your physician.This page may be reproduced noncommercially by physicians and other health care professionals to share with patients.Any other reproduction is subject to AMA approval.