tbuckley/cabot-search huggingface dataset:
Percutaneous Balloon Catheterization
Authors: Stuart B. Paster
Journal: JAMA (1974)

We have employed balloon catheters to establish hemostasis in two patients with arterial hemorrhage caused by pelvic trauma. The catheters were introduced percutaneously under fluoroscopic guidance with a standard catheter-guidewire system. Within 24 hours, the bleeding had ceased in both patients. No sequelae associated with the therapy developed. Alternative therapy for these patients is surgical arterial ligation or clot embolization. Both of these approaches have inherent hazards that are obviated by balloon obstruction. (<i>JAMA</i>230:573-575, 1974)
Predictors of and trends in high-intensity end-of-life care among children with cancer: A population-based study using health services data.su.
Authors: Sumit Gupta, Rinku Sutradhar, Jason D Pole, Alisha Kassam, Adam Rapoport, Katherine Nelson, Craig Earle, Joanne Wolfe, Kimberley Widger
Journal: Journal of Clinical Oncology (2016)

10521 Background: Children with cancer often receive high-intensity (HI) medical care at the end-of-life (EOL), possibly increasing already high symptom burdens. Previous EOL studies are limited to single centers or lack detailed clinical data. We determined predictors of and trends in HI-EOL care by linking population-based clinical and health services databases. Methods: A retrospective cohort of all children with cancer who died 2000-2012 in Ontario, Canada was assembled using the provincial childhood cancer registry POGONIS, and linked to population-based healthcare data capturing all inpatient, outpatient, emergency (ER) and home care visits. The primary composite outcome, HI-EOL care, comprised any of: IV chemotherapy < 14 days from death; > 1 ER visit, > 1 hospitalization, or any intensive care unit (ICU) admission < 30 days from death. Secondary outcomes included individual indicators and measures of highest intensity EOL care [e.g. mechanical ventilation (MV) < 14 days of death]. We determined predictors of study outcomes with appropriate regression models. In sensitivity analyses, we used POGONIS cause of death data to exclude cases of treatment-related mortality (TRM). Results: 815 patients met inclusion criteria. 331 (40.6%) experienced HI-EOL care, with patients with hematologic malignancies at significantly higher risk [odds ratio (OR) 2.5, 95thconfidence interval 1.8-3.6; p < 0.001)]. Patients with hematologic cancers, living close to a treatment center, and who died in 2005-2008 and 2009-2012 were significantly more likely to experience indicators of highest intensity care (e.g. ICU, MV; ORs ranging from 2.2-4.9). Excluding cases of TRM did not substantively change the results. Conclusions: Ontario children with cancer continue to experience HI care at the EOL. Patients with hematologic malignancies are at highest risk even when excluding those with TRM. Worryingly, rates of highest intensity EOL care have increased over time despite increased palliative care access. Linkage of health services and clinical data offers a method of monitoring population trends in EOL care and identifying high-risk populations targetable by future interventions.
Nordisk Medicin, Copenhagen
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Modern Progress and History.
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Combination of the hyperCVAD Regimen with Dasatinib Is Effective in Patients with Relapsed Philadelphia Chromosome (Ph) Positive Acute Lymphoblastic Leukemia (ALL) and Lymphoid Blast Phase Chronic Meyloid Leukemia (CML-LB)
Authors: Elias Jabbour, Susan O’Brien, Deborah A. Thomas, Stefan Faderl, Charles Asa Koller, Samuel Dara, Rebecca Garris, Jorge Cortes, Hagop M Kantarjian, Farhad Ravandi
Journal: Blood (2008)
The Indolizidine Alkaloids, Slaframine and Swainsonine: Contaminants in Animal Forages
Authors: H. Broquist
Journal: Annual Review of Nutrition (1985)

The Indolizidine Alkaloids, Slaframine and Swainsonine: Contaminants in Animal Forages, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/nutr/5/1/annurev.nu.05.070185.002135-1.gif
Paths
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction
Journal: Endoscopy (2003)

Polkowski, M, Regula J, Wronska E, Pachlewski J, Rupinski M, Butruk E. Endoscopic Ultrasonography for Prediction of Postpolypectomy Bleeding in Patients with Large Nonpedunculated Rectosigmoid Adenomas. Endoscopy 2003; 35: 343 -347.
Catecholamine Stimulation, Substrate Competition, and Myocardial Glucose Uptake in Conscious Dogs Assessed with Positron Emission Tomography
Authors: Michael E. Merhige, Robert Ekas, Kurt Mossberg, Heinrich Taegtmeyer, K. Lance Gould
Journal: Circulation Research (1987)

Uptake of radiolabelled deoxyglucose out of proportion to reduced coronary flow demonstrated by positron emission tomography has been used to identify reversibly ischemic, viable myocardium.For this concept to be applied reliably in the clinical setting, factors that may depress glucose availability independent of tissue viability, such as adrenergic stimulation and substrate competition, must be examined.Accordingly, we studied the effect of catecholamine stimulation by dopaniine on myocardial glucose uptake in vivo using chronically instrumented, intact dogs and positron emission tomography.We measured myocardial activity of [2-18 F]-2-deoxyglucose (FDG) and M Rb in glucose-loaded animals randomly studied during dopamine infusion, during insulin infusion, and then during their combined infusion.Myocardial FDG uptake was significantly decreased when animals were treated with dopamine, compared with treatment in the same animals with insulin.When insulin was added to the dopaniine infusion, myocardial FDG uptake was restored.In contrast, myocardial activity of 82 Rb, which is taken up in proportion to coronary flow, was similar under all three experimental conditions.Plasma glucose, free fatty acid, and lactate concentrations were determined before and during each infusion.The depression of myocardial FDG activity seen during dopamine infusion and its reversal with addition of insulin can be explained on the basis of effects of these hormones on substrate availability and competition.(Circulation Research 1987;61(suppl II):II-124-11-129) R elative uptake of the major fuels of the heart, i.e., free fatty acids, glucose, and lactate, de-" pend primarily on their arterial concentrations. 1 Under fasting conditions, free fatty acid levels rise in plasma, providing up to 70% of myocardial energy requirements.After a carbohydrate meal, glucose becomes the major cardiac fuel.During vigorous exercise, lactate may serve as the major substrate for myocardial intermediary metabolism.Under hypoxic conditions, there is a marked increase in myocardial glucose uptake as glycolytic flux increases in response to falling intracellular citrate and ATP levels.This shift toward anaerobic glucose utilization has been used to identify ischemic viable myocardium during experimental infarction in animals as well as clinically by positron emission tomography (PET) in patients with acute myocardial infarction.Ischemic but viable tissue is metabolically active and may be recognized by the uptake of radiolabelled glucose analogues out of proportion to coronary flow. 2 For this concept to be valid, factors that may depress glucose uptake in the heart, independent of tissue via-
PEKING, CHINA
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Wilson's Disease: A Correction
Journal: BMJ (1946)

MEDICAL JOURNAL is healthy and there are no vitamin or hormone deficiencies there is no treatment indicated at present.Absence of teeth is not infrequently hereditary.It is of interest in this particular case that the mother had no lower incisors.Unfortunately if the condition is hereditary there are no known precautions that can be taken to prevent a similar condition in the next child, though of course such absence may not necessarily be an inherited character with every child. Cocaine SensitivitxQ.-M) Does cocaine seaisitizalion exist or is it a myth ?(2) Is it safe to use cocaine hlydrochlloride as a local andes- thetic injected into the tissues ?(3) Is it safe to use a cocaine hYdrochloride throat spray (say' 10% as a preparation for laryngeal intubation) as a routtinie without first testing for susceptibility ?A.-(l) Cocaine sensitization exists in the sense that some people require very much less cocaine to acquire a certain degree of anaesthesia than others; it exists also in the sense
Masthead: (Adv. Healthcare Mater. 20/2016)
Journal: Advanced Healthcare Materials (2016)

Citizenship: Wiley's Corporate Citizenship initiative seeks to address the environmental, social, economic, and ethical challenges faced in our business and which are important to our diverse stakeholder groups.Since launching the initiative, we have focused on sharing our content with those in need, enhancing community philanthropy, reducing our carbon impact, creating global guidelines and best practices for paper use, establishing a vendor code of ethics, and engaging our colleagues and other stakeholders in our efforts.
Variations in cataract extraction rates in Medicare prepaid and fee-for-service settings
Authors: C. L. Goldzweig
Journal: JAMA (1997)

Objective.\p=m-\Tocomparerates of cataract extraction in 2 prepaid health settings and in traditional fee-for-service (FFS) settings.Design.\p=m-\A cross-sectional analysis using 1993 health maintenance organization (HMO) Medicare claims and encounter files, the Health Care Financing Administration (HCFA) 5% Medicare Part B provider/supplier file, and the HCFA October 1992 100% Medicare population file.Setting.\p=m-\SouthernCalifornia Medicare FFS settings and the staff-model and independent practice association (IPA) plans of a large California HMO.Patients.\p=m-\1993Medicarebeneficiaries aged 65 years and older.The study in- cluded 43 387 staff-model HMO enrollees, 19050 IPA enrollees, and 47150 FFS beneficiaries (a 5% sample of all Southern California FFS beneficiaries).Main Outcome Measure.\p=m-\Age and risk-factor adjusted rates of cataract extraction per 1000 beneficiary-years.Results.\p=m-\After controlling for age, sex, and diabetes mellitus status, FFS ben- eficiaries were twice as likely to undergo cataract extraction as were prepaid ben- eficiaries (P<.01).Female FFS beneficiaries were nearly twice as likely to undergo the procedure as were male FFS beneficiaries (P<.001); there were no extraction rate differences by sex in the prepaid settings.Conclusion.\p=m-\Becauseof the potential implications for vision care in the elder- ly, the significantly different rates of cataract extraction in FFS and prepaid settings warrant further clinical investigation to determine whether there is overuse in FFS vs underuse in prepaid settings.Such investigations must assess the appropriateness of cataract surgery by evaluating its use relative to clinical need.
Septicemia and total parenteral nutrition. Distinguishing catheter-related from other septic episodes
Authors: J. D. Dillon
Journal: JAMA (1973)

Septic episodes in 122 patients receiving total parenteral nutrition (TPN) were analyzed to determine criteria helpful in distinguishing catheterrelated septicemia from septicemia due to other causes. The five patients (4.1%) with catheter-related septicemia had positive blood and cathetertip cultures with the same organism and no other site of infection with that organism. Four of the six organisms recovered were either<i>Candida</i>or staphylococci. The 14 patients (11.5%) with septicemia due to other causes had positive blood cultures but negative catheter-tip cultures. Another site could be demonstrated to be infected with the same organism and was thought to be the origin of the bacteremic episode. Of the organisms recovered, 83% were gram-negative bacilli or enterococci. The implication of TPN catheters in the genesis of septicemia may be exaggerated in the literature.
Dioxinlike Properties of a Trichloroethylene Combustion-Generated Aerosol
Authors: S. Alex Villalobos, Michael J. Anderson, Michael S. Denison, David E. Hinton, Katherine Tullis, Ian M. Kennedy, A. Daniel Jones, Daniel P. Y. Chang, GoSu Yang, Peter Kelly
Journal: Environmental Health Perspectives (1996)

Conventional chemical analyses of incineration by-products identify compounds of known toxicity but often fail to indicate the presence of other chemicals that may pose health risks. In a previous report, extracts from soot aerosols formed during incomplete combustion of trichloroethylene (TCE) and pyrolysis of plastics exhibited a dioxinlike response when subjected to a keratinocyte assay. To verify this dioxinlike effect, the complete extract, its polar and nonpolar fractions, some containing primarily halogenated aromatic hydrocarbons, were evaluated for toxicity using an embryo assay, for antiestrogenicity using primary liver cell cultures, and for the ability to transform the aryl hydrocarbon receptor into its DNA binding form using liver cytosol in a gel retardation assay. Each of these assays detect dioxinlike effects. Medaka (Oryzias latipes) embryos and primary liver cell cultures of rainbow trout (Oncorhynchus mykiss) were exposed to concentrations of extract ranging from 0.05 to 45 micrograms/l. Cardiotoxicity with pericardial, yolk sac, and adjacent peritoneal edema occurred after exposure of embryos to concentrations of 7 micrograms/l or greater. These same exposure levels were associated with abnormal embryo development and, at the higher concentrations, death. Some of the fractions were toxic but none was as toxic as the whole extract. In liver cells, total cellular protein and cellular lactate dehydrogenase activity were not altered by in vitro exposure to whole extract (0.05-25 micrograms/l). However, induction of cytochrome P4501A1 protein and ethoxyresorufin O-deethylase activity occurred. In the presence of whole extract, estradiol-dependent vitellogenin synthesis was reduced. Of the fractions, only fraction 1 (nonpolar) showed a similar trend, although vitellogenin synthesis inhibition was not significant. The soot extract and fractions bound to the Ah receptor and showed a significantly positive result in the gel retardation/DNA binding test. Chemical analyses using GC-MS with detection limits for 2,3,7,8-tetrachlorodibenzo-p-dioxin and dibenzofuran in the picomole range did not show presence of these compounds. Our results indicate that other chemicals associated with TCE combustion and not originally targeted for analysis may also pose health risks through dioxinlike mechanisms.
Abstract 3380: Methylome analysis of non-alcoholic fatty liver disease-associated hepatocellular carcinoma reveals etiology-specic pathway perturbations
Authors: Qiong Wu
Journal: Cancer Research (2019)

Abstract Chronic hepatitis B infection (HBV) and non-alcoholic fatty liver disease (NAFLD) have been shown to induce aberrant DNA methylation that may contribute to the development of hepatocellular carcinoma (HCC), which is one of the most common liver cancers. Most previous studies on DNA methylation in HCC have focused on altered methylation at gene promoters and CpG islands/shores. However, it has been increasingly recognized that DNA methylation in other genomic regions, including distal enhancers and gene bodies, could also play important roles in gene regulation in cancers. In our whole-genome bisulfite sequencing (WGBS) analysis of 10 human HBV-associated tumors and 10 human NAFLD-associated tumors, methylation states at all CpG sites in the genome of HCC tumors are comprehensively studied. To see how the methylomes of these two groups of HCC samples are related to other liver-related normal and pathogenic samples, we collected published WGBS data for HCC tumor, tumor adjacent and normal liver samples. Global hypermethylation of NAFLD-HCC has been identified compared with HBV-HCC and differentially methylated regions in enhancer and gene body regions also have been detected. Different methylation patterns for HCC pathogenesis with different etiologies have been detected and may offer potentially more specific therapeutic targets. This project is supported by Collaborative Research Fund C4017-14G and the Focused Innovations Scheme 1907309. Citation Format: Qiong Wu. Methylome analysis of non-alcoholic fatty liver disease-associated hepatocellular carcinoma reveals etiology-specic pathway perturbations [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3380.
Abstract 2087: Mechanistic studies reveal novel molecular insights on anticancer properties of F10 compound in human colon cancer cells
Authors: Chinnadurai Mani, William Gmeiner, Komaraiah Palle
Journal: Cancer Research (2019)

Abstract Fluoropyrimidine (FP) drugs, mainly 5-Fluorouracil (5-FU), constitute the backbone of combination chemotherapy regimens (e.g. FOLFOX and FOLFIRI) for treating colorectal cancer (CRC) and provide a survival benefit for patients with stage II, III, and IV colorectal cancer. However, 5 year survival rate for CRC patients with metastatic disease is less than 10%. This dreadful situation suggests urgent need for novel and more potent FPs to improve the outcomes of these patients. We have developed novel fluoropyrimidine drug polymers (e.g. F10) that show promising antitumor activity in multiple pre-clinical models even while displaying reduced systemic toxicities. F10 is taken up by malignant cells via active transport compared to 5-Fluorouracil, which is taken up by diffusion in malignant and non-malignant cells. Additionally, F10 compound is primarily incorporated into DNA, and produced thymidylate synthase and topoisomerase toxic metabolites at greater levels, whereas 5-Fluorouracil is primarily incorporated into RNA, and only has about 5-10% production of active form of thymidylate synthase toxic metabolites. MMR is involved in repairing the DNA mismatches and FP drugs induced DNA damage. Interestingly, our studies show that F10 acts by different mechanisms compared to 5-FU. Particularly, F10 treated CRC cells exhibit replication stress as evidenced by paused and slow progression of replication forks and R-loops formation at the active transcriptional regions, suggesting replication and transcription dependent generation of DNA lesions in these cells. F10 treatment induced several fold increased DNA double strand breaks (DSB) as measured by COMET assays and about 1000 folds more cytotoxicity to CRC cells compared to 5-FU. Similarly, F10 treatment activated distinctive DNA damage responses in MMR proficient CRC cells compared MMR deficient cells. Additionally, our studies suggest F10 as a promising therapeutic agent for CRC therapy either alone or in combination with CHK1 and PARP inhibitors. Citation Format: Chinnadurai Mani, William Gmeiner, Komaraiah Palle. Mechanistic studies reveal novel molecular insights on anticancer properties of F10 compound in human colon cancer cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2087.