tbuckley/cabot-search huggingface dataset:
Hypertensive pulmonary arteritis
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Text-Book of Diseases of the Eye. A Handbook of Ophthalmic Practice for Students and Practitioners.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PROGRAM OF SECTIONS.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SWINE POX AND VACCINIA
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
WITCHCRAFT EPIDEMICS IN THE UNITED STATES.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Morphometry of the liver after liver transplantation in the rat: Significance of an intact arterial supply
Authors: D Zhao
Journal: Hepatology (1993)

Two models of orthotopic liver transplantation in the rat currently used are with and without reconstruction of the hepatic artery. The aim of this study was to assess the importance of the arterial blood supply to liver structure after orthotopic liver transplantation with advanced morphometric methods. Orthotopic liver transplantation was performed in male Lewis rats, of which 11 underwent reconstruction of the hepatic artery and 11 did not. A group of untreated controls (n = 5) and a group of animals with hepatic artery ligation (n = 4) were included. Eight weeks after surgery liver tissue was harvested and subjected to systematic random sampling. A point-counting method was used, volume fractions of tissue components were determined. Liver samples from rats that underwent hepatic artery reconstruction had preserved lobular architecture, and estimated bile duct (0.71% ± 0.33% [S.D.]) and connective tissue (1.89% ± 0.52%) volumes were not significantly different from those of controls (bile duct, 0.34% ± 0.17%; connective tissue, 0.70% ± 0.07%). In contrast, liver samples from rats that did not undergo hepatic artery reconstruction showed bile duct proliferation (7.19% ± 4.83%; p < 0.05) and an increase in connective tissue volume (7.54% ± 3.68%; p <0.05) associated with a decrease in hepatocyte volume (controls, 87.3% ± 0.3%; rats that underwent arterialization, 85.5% ± 1.0%; rats that did not undergo arterialization, 73.2% ± 8.2% [p < 0.05]). Interestingly, hepatic artery ligation had no significant effect on any parameter. These findings show that in contrast to orthotopic liver transplantation with arterialization, orthotopic liver transplantation without arterialization may lead to derangement of liver structure, thus demonstrating the crucial role of an intact arterial supply for the biliary tree in orthotopic liver transplantation. The lack of change with hepatic artery ligation may indicate the presence of an additional arterial supply to the bile duct under normal conditions. (HEPATOLOGY 1993;17:310–317.)
The hospitalized elderly
Authors: J. S. Tobis
Journal: JAMA (1982)

The White House Conference on Aging of 1981 has awakened much of the American public to the importance of the elderly as a political constituency. The marked rise in our country in the percentage of people 65 years or older from 4% in 1900 to 1196 today<sup>1</sup>reflects in part a reason for this awakening. Concomitant with this rise in the population of the elderly is the anticipation that federal expenditures for this group will increase from 25% of the federal budget for 1981 to above 3296 by the year 2000. With these major demographic and economic changes, community services—including health care—must be vigorously reassessed to meet more effectively the needs—and demands—of this politically powerful segment of our society. This population of people older than 65 years contributes to 2396 of hospital discharges and 3596 of total hospital days and experiences 5096 longer stays in hospital.<sup>2</sup> In this
DANGERS FROM THE USE OF PROPRIETARY REMEDIES.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Exaggeration of acute liver damage by hepatic sympathetic nerves and circulating catecholamines in perfused liver of rats treated withD-galactosamine
Authors: M Iwai, T Shimazu
Journal: Hepatology (1996)

Effects of electrical stimulation of the hepatic nerves on acute liver damage were examined using isolated rat liver perfused in situ , 24 hours after intraperitoneal injection with d-galactosamine (800 mg/kg). The leakage of lactate dehydrogenase (LDH) and aspartate aminotransferase (AST) from the liver was used as markers of acute liver damage. In perfused livers after treatment with galactosamine, nerve stimulation (20 V, 20 Hz, 2 ms) increased the leakage of LDH and AST about 3-fold over the basal level accompanied by the decrease in flow rate, whereas with control livers the leakage of LDH and AST into the effluent was almost undetectable throughout the perfusion. The rapid increase in the leakage of LDH and AST was observed during nerve stimulation even under conditions where perfusion flow was maintained constant. Such effects of hepatic nerve stimulation on galactosamine-treated livers were mimicked well by infusion of noradrenaline or phenylephrine, and inhibited by the α 1 -antagonist bunazosin. Artificial reduction of perfusion flow alone did not induce the rapid leakage of LDH and AST into the effluent. On the other hand, low concentration (10 nmol/L) of noradrenaline only minimally decreased the flow rate but apparently augmented liver cell damage. The acute liver damage augmented by noradrenaline was dependent on extracellular Ca 2+ . These results indicate that in the liver, already having been injured slightly, the activation of hepatic sympathetic nerves and circulating catecholamines exaggerates acute liver damage through an action on liver cells, which depends on the influx of extracellular Ca 2+ .
Medicinal Foods.
Authors: David L. Edsall
Journal: JAMA (1907)

Philadelphia, May 11, 1907. <h3>To the Editor:</h3> —The report of the Council on Pharmacy and Chemistry in regard to medicinal foods inThe Journal, May 11, 1907, is exceedingly important and most instructive. The knowledge that we had before was such as to have led very many exact and thoughtful clinicians to consider these foods of extremely limited value. The report gives most clear and impressive evidence that this is indeed true. In the teaching and practice of dietetics we need more than anything else, I think, greater exactness. We need this most of all in those cases in which the diet is necessarily very restricted and in which, consequently, inaccuracies may be dangerous. The report is especially welcome, therefore, for it is in this class of cases that these foods are most likely to be used and misconceptions regarding their value are very general. The common use of these
Abstract 319: Cardiomyocyte-specific Overexpression of Type 5 Phosphodiesterase Impairs Postinfarction Myocardial Function and Left Ventricular Remodeling.
Authors: Peter Pokreisz, Marijke Pellens, An Van Den Bergh, Hilde Gillijns, Virginie Bito, Ilse Lenaerts, Liesbeth Biesmans, Glenn Marsboom, Pieter Vermeersch, Jan D’hooge, Karin Sipido, Paul Herijgers, Luc Schoonjans, Kenneth D Bloch, Stefan Janssens
Journal: Circulation (2007)

Background : Cyclic guanosine monophosphate (cGMP), a second-messenger regulator of cardiovascular function, modulates acute and chronic stress responses in the heart. Myocardial cGMP levels are determined by the balance between production via guanylate cyclases and hydrolysis via phosphodiesterases (PDEs). To better understand the role of cGMP hydrolysis in the myocardial response to hemodynamic challenge, we generated transgenic mice with cardiomyocyte-specific overexpression of a cGMP-specific PDE (PDE5TG) and compared the LV remodeling response to myocardial infarction (MI) with wild-type littermates (WT). Methods : PDE5 expression was examined in hearts of WT and PDE5TG using qRT-PCR, immunoblot analysis, confocal microscopy, and measurement of cGMP hydrolysis. Cell shortening and calcium (Ca) handling were determined in paced cardiomyocytes from adult PDE5TG (n = 7) and WT (n = 5). LV function and dimensions, as well as hemodynamic parameters, were compared in anesthetized PDE5TG and WT using echocardiography and pressure-volume catheter techniques at baseline (n = 20) and 10 weeks after proximal LAD ligation (n = 16). Results : The PDE5 transgene was selectively but homogeneously expressed in cardiomyocytes of PDE5TG and resulted in a 10-fold increase in cGMP hydrolysis. Ca transients, Ca currents and cell shortening did not differ between PDE5TG and WT cardiomyocytes and baseline echocardiographic and hemodynamic parameters were comparable. After MI, cardiac dimensions were larger in PDE5TG than in WT and for a similar infarct size, LV end-diastolic volumes and pressures were larger in PDE5TG than in WT (81 ± 15 vs 50 ± 20 μL, P &lt; 0.01 and 9 ± 5 vs 4 ± 4 mmHg, P &lt; 0.05 respectively), and isovolumic relaxation was more prolonged (11 ± 2 vs 8 ± 3 ms, P = 0.01). Preload-recruitable stroke work and maximal elastance tended to be lower in PDE5TG than in WT (P = 0.07 and 0.05, respectively). After MI, extravascular lung water weight was greater in PDE5TG than in WT (P &lt; 0.05). Conclusions : Cardiomyocyte-specific overexpression of PDE5 does not alter baseline cardiac structure or function, but significantly impairs systolic and diastolic function and LV remodeling after MI. Myocardial PDE signaling is an important novel target in post-infarction heart failure.
Nuclear Export of the NF-κB Inhibitor IκBα Is Required for Proper B Cell and Secondary Lymphoid Tissue Formation
Authors: Shelly M. Wuerzberger-Davis, Yuhong Chen, David T. Yang, Jeffrey D. Kearns, Paul W. Bates, Candace Lynch, Nicholas C. Ladell, Mei Yu, Andrew Podd, Hu Zeng, Tony T. Huang, Renren Wen, Alexander Hoffmann, Demin Wang, Shigeki Miyamoto
Journal: Immunity (2011)
Book Review Medical Diseases of War . By Sir Arthur Hurst, D.M. (Oxon.), F.R.C.P. With the co-operation of H. W. Barber, M.B. (Cantab.), F.R.C.P.; H. B. F. Dixon, M.D. (Dub.), F.R.C.P.; F. A. Knott, M.D. (Lond.), M.R.C.P.; T. A. Ross, M.D. (Edin.), F.R.C.P.; and Arnold W. Stott, M.A. (Cantab.), F.R.C.P. Second edition. 8°, cloth, 427 pp., with 8 plates. Baltimore: The Williams and Wilkins Company, 1941. $5.50.
Journal: New England Journal of Medicine (1943)
Gastrointestinal bleeding
Authors: Mário Dinis-Ribeiro
Journal: Endoscopy (2013)

GI bleeding remains an important health outcome. A significant number of abstracts were presented during Digestive Disease Week in Orlando, Fla, from May 18 to 21, 2013, noting the global management of patients with GI bleeding and reporting the efficacy of endoscopic interventions for upper or lower GI bleeding, the management after bleeding occurring as a complication of diverse therapeutic interventions in the GI tract. Presented here is a putative summary of the most relevant abstracts.
Editorial Board
Authors: Lekshmy Balakrishnan, Milka Kostic, Basil Nyaku, Peggy Kristanto, Philip Patenall, S Amara, N Birdsall, N Bowery, J Crawley, A Cuello, B Fredholm, L Hunyady, T Kenakin, M Mishina, W Moolenaar, C Page, R Ruffolo, R Summers, Australia Tanaka, Japan Watson, Andrew Holmes, Lin Shen, S Alireza, Robert Siliciano, Michael Bird, Andrew Lawrence
Journal: Trends in Pharmacological Sciences (2009)
More cautionary labeling appears on isotretinoin
Authors: C. Marwick
Journal: JAMA (1984)

The Food and Drug Administration and Roche Laboratories, Nutley, NJ, have agreed on more cautionary labeling for the company's isotretinoin (Accutane) anti-acne product. The laboratories are a division of Hoffmann-LaRoche Inc. The labeling contains two boxed warnings that were not in the earlier version. These emphasize in boldface type that the drug should not be used by women who are pregnant or who have immediate plans to become pregnant. The warning also draws attention to the association of isotretinoin with cases of pseudotumor cerebri, pointing out that early signs of this disorder include papilledema, headache, nausea and vomiting, and visual disturbances. Further, in what is held by some to be an unusual move, the FDA has advised the blood banking community that patients receiving isotretinoin should not donate blood for transfusion for 30 days after use of the drug. The director of the Division of Blood
The long-term pathological evolution of chronic hepatitis C
Authors: M Yano
Journal: Hepatology (1996)

Most patients infected with hepatitis C virus (HCV) develop chronic hepatitis. Unfortunately, the pathological evolution of this disease over time is not completely understood. We studied 70 HCV-positive patients, from whom 2 to 10 liver biopsy specimens (mean, 3.9) had been obtained during an interval of 1 to 26 years (mean, 8.8 years). Each biopsy specimen was evaluated independently by four pathologists who each provided a numerical score for the grade of portal/periportal necroinflammation (0-4), grade of lobular necroinflammation (0-4), their sum (final grade), and the stage of fibrosis (1-4). The scores were correlated with progression of disease, if any, and transition to cirrhosis. During follow-up, 35 patients (50%) developed cirrhosis. Cirrhosis developed in all patients with a high final grade (≥ 5) of necroinflammation on initial biopsy who were followed for 10 years and in 96% of patients with an intermediate final grade (3.5-4.9) who were followed for 17 years. Only 30.4% of patients with low final grade (≤ 3.4) on initial biopsy developed cirrhosis after 13 years. All patients with evidence of septal fibrosis with incomplete nodularity (stage 3.0-3.4) in the initial biopsy progressed to unequivocal cirrhosis by 10 years. The rate of progression to cirrhosis was accelerated in patients whose initial biopsies showed high-grade and -stage lesions. This study demonstrates the importance of grading and staging liver biopsy lesions in chronic hepatitis C, particularly for patients with high-grade necroinflammation, septal fibrosis, and regions of modularity on initial biopsy who are at high risk of developing advanced cirrhosis in the ensuing decade.
Book Review The Kosher Code of the Orthodox Jew: Being a literal translation of that portion of the sixteenth-century codification of the Babylonian Talmud which describes such deficiencies as render animals unfit for food (Hilkot Terefot, Shulhan 'Aruk); to which is appended a discussion of Talmudic anatomy in the light of the science of its day and of the present time . By S. I. Levin and Edward A. Boyden, Ph.D. 8°, cloth, 243 pp., with 5 illustrations. Minneapolis: University of Minnesota …
Journal: New England Journal of Medicine (1940)
Tests on the pill for carcinogenicity.
Authors: M Lamy
Journal: BMJ (1972)

OCTOBER 1972 on the risks of future children being affected the specific genetic syndromes should first be considered.The recurrence risk will be that for the syndrome.In cases due to progestin or sex chromosome anomalies the risk for future offspring will usually be sma For the rest, the empirical risk for later brothers of patients born to unaffected fathers may be taken to be about 10%.1 S0rensen, H. R. Hypospadias with Special Reference to Aetiology.
Ethics and Regulation of Clinical Research
Authors: John A. Robertson
Journal: JAMA (1982)

Research with human subjects is an essential part of modern medicine. Since the 1960s, when knowledge of research abuses surfaced and federal regulation of human subject research began, it has been a focus of ethical and regulatory controversy. Today, a regulatory system of prior review by mixed-peer bodies, called "institutional review boards" (IRBs), is firmly in place in every hospital, medical school, and research facility in the country. Robert Levine's<i>Ethics and Regulation of Clinical Research</i>is an excellent summary of the key ethical and regulatory issues that arise in running the IRB system. The author draws on his wide experience in human subject research as chair of the Human Use Committee of the Yale University School of Medicine, as consultant and member of various national commissions, as editor of<i>Clinical Research</i>and<i>IRB: A Review of Human Subject Research</i>, and as a prolific writer and speaker on the subject.