tbuckley/cabot-search huggingface dataset:
Special Reports, Announcements, and Notices
Journal: JAMA (1967)

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Dictionary of Volapük: Volapük-English; English-Volapük.
Journal: JAMA (1889)

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Senility reconsidered. Treatment possibilities for mental impairment in the elderly. Task force sponsored by the National Institute on Aging
Journal: JAMA (1980)

The brain is particularly vulnerable to insults occurring anywhere in the body. In some older persons, the brain may respond to insult by slowly developing impairment of intellectual functions (dementia) or abruptly showing significant changes in mental state (delirium). Sometimes the two coincide, producing a variable clinical picture with features of both dementia and delirium. It is crucial for health professionals, public planners, and lay persons to recognize that many curable physical and psychological diseases in the elderly produce intellectual impairment that may be hard to distinguish from irreversible brain disease.
The Cryptic Chromosomal Deletion, del(11)(p12p13), as a New Activation Mechanism of LMO2 in Pediatric T-Cell Acute Lymphoblastic Leukemia.
Authors: Pieter Van Vlierberghe, Martine van Grotel, H. Berna Beverloo, Charles Lee, Tryggvi Helgason, Jessica Buijs-Gladdines, Monique Passier, Elisabeth R. van Wering, Anjo J.P. Veerman, Willem A. Kamps, Jules P.P. Meijerink, Rob Pieters
Journal: Blood (2006)
Traduttore, traditore
Journal: JAMA (1986)

<h3>In Reply.—</h3> Few of my papers have given me such gratification and such a feeling of having said exactly what I wanted to say as "My Dear Colleague: Are You Considering Suicide?" Almost none has elicited the intensity of response expressed in the two letters published above. Dr Sargent worked mightily on the joint American Medical Association/ American Psychiatric Association Advisory Panel on Physician Mortality. The work of his group has improved our ability to predict when physicians are at risk and to act with confidence to help prevent their suicides. The profession owes Dr Sargent and his co-workers heartfelt thanks. I now turn to his "quibbles." Indeed, at the moment that a potential victim reaches the decision to commit suicide he may be irrational. My appeal, consistent with my thesis of "confrontation and engagement," is for appropriate intervention before the potential victim has lost control. It is probable that
International Comments
Journal: JAMA (1974)

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A History of Medicine
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Effect of Critical Fusion Frequency Light Time: Dark Time Ratio and Luminance on Peripheral Sensitivity to Flicker
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Violence
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Corrosive Poisoning
Authors: J. D. P. Graham
Journal: BMJ (1955)

A corrosive is a substance which causes destruction of tissue at the site of application; in dilute solution many corrosives merely have an irritant effect, but irritants may corrode at certain sites.According to this definition the effects of a corrosive should be limited to its local action, but some of them produce serious effects from absorption, so the classification is a loose one.Corrosives may be defined more accurately therefore as " substances having an acute and predominantly local action involv- ing destruction of tissue."The speed and the destructive nature of the poisoning constitute an emergency in which early and effective treatment is essential. IncidenceAccording to the Registrar-General's Statistical Reviews, corrosives are an infrequent cause of death (see Table ).
Prognostic value of HPV infection by E1 detection and p16 expression in 78 oropharyngeal squamous cell carcinomas
Authors: C.L.o. Nigro, D. Vivenza, L. Lattanzio, M. Fortunato, N. Denaro, C. Varamo, M. Ferrero, E. Russi, M.C. Merlano
Journal: Annals of Oncology (2016)
Use of 2-Acetamidophenanthrene and 2-Acetamidofluorene in Investigations of Mechanisms of Hepatocarcinogenesis
Authors: John D. Scribner, Becky Woodworth, Gertrud Koponen, Eric H. Holmes
Journal: Environmental Health Perspectives (1983)

Comparison studies have been undertaken on the hepatocarcinogen 2-acetamidofluorene (AAF) and its nonhepatocarcinogenic analog 2-acetamidophenanthrene (AAP). Previous studies have shown that amount of compound acutely and persistently bound to rat liver DNA is comparable for the two compounds following single injections into adult Fischer rats, but that AAP fails to initiate tumors in weanling Sprague-Dawley rats. In this work we show that the amount of bound adduct from AAF and AAP is also comparable after three weeks of feeding compound to weanling Sprague-Dawley male rats. Three of the adducts found in RNA of AAP-treated rats cochromatographed on Sephadex LH-20 with two adenosine adducts and one guanosine adduct prepared by reaction of the nucleosides with N-acetoxy-N-trifluoroacetyl-2-aminophenanthrene at neutrality. Because of the lack of initiating ability of AAP in liver, we have also investigated early biochemical alterations in liver after various regimens. Feeding of either AAF or AAP to male weanling rats, followed by three weeks of DDT feeding produced no alteration in either histochemically detected γ-glutamyltranspeptidase or in ganglioside complement in total liver homogenate. Partial hepatectomy after feeding of either AAF or AAP resulted in the appearance of new fucoganglioside and alteration in the distribution of the major gangliosides. DDT feeding after partial hepatectomy resulted in foci of elevated gamma-glutamyltranspeptidase in AAF-fed rats but not in AAP-fed rats. These results support a previous proposal that AAP may initiate tumorigenesis in rat liver, but that the promoting regimens now in use lack the ability to cause further progression of the initiated cells. The data also suggests that ganglioside synthesis may be a more sensitive marker for early stages in carcinogenesis than are the various histochemical stains now in use.
Further characterization of IgE-binding antigens in horse dander, with particular emphasis on glycoprotein allergens
Authors: T. K. Johnsen, D. B. Thanh, Q. Ly, B. Smestad Paulsen, J. K. Wold
Journal: Allergy (1996)

IgE-binding components in an extract of horse dander were analyzed, especially with regard to the glycoprotein allergens. After SDS-PAGE under reducing conditions and blotting, several of the glycoprotein IgE-binding components, including two distinct bands of 27 and 31 kDa, were detected. Together with several other bands, they were shown to bind to the lectins Sambucus nigra agglutinin (SNA) and Datura stramonium agglutinin (DSA), indicating terminal sialic acid linked α2→6 to galactose, and galactose linked β1→ 4 to N-acetylglucosamine, respectively. Carbohydrate analysis after SDS-PAGE and blotting showed the presence of mannose, galactose, N-acetylglucosamine, and N-acetyl neuraminic acid in the 27-kDa band. The 14.4-kDa glycoprotein component lost its IgE-binding activity after periodate oxidation. Minor differences in allergenic activity in the other glycoprotein allergenic components were also detected, indicating that the carbohydrate part of the molecule seems to play a role in the IgE-binding activity. Two-dimensional electrophoresis and subsequent immunoblotting were performed to estimate the approximate number, molecular mass, and pI of IgE-binding components. This resulted in a cluster of such components on the blot membrane.
Intestinal Intubation
Authors: Lee Stataline
Journal: JAMA (1975)

<h3>To the Editor.—</h3> Dr Palmer's commentary on intestinal intubation (233:818, 1975) is, as usual, informative and practical. However, in the interest of reduced dry cleaning bills, may I suggest that instead of having the patient drink or sip water to facilitate swallowing the tube, have him clench a water-soaked, folded 10×10-cm gauze pad between his teeth. Thus, by biting down on the gauze the patient obtains water for swallowing. He will not damage the tube, and should he cough, the wet rag will cause less sartorial soilage than an oral tidal wave.
NEW STATE MEDICAL JOURNALS.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Errata
Journal: JNCI Journal of the National Cancer Institute (1960)

In Table 1, page 157, under column “Compound,” in 3rd box from bottom of page: In the paper entitled “Studies of Carcinogenicity in the Rat of Derivatives of Aromatic Amines Related to N-2-fluorenylacetamide,” by Harold P. Morris et al., for “N-2-fluorenyl-π-toluenesulfonamide” read “N-2-fluorenyl-p-toluenesulfonamide.”
Albumin
Authors: James L. Tullis
Journal: JAMA (1977)

PARTLY on the basis of the physiologic information given in part 1 and partly on the basis of empiric observations derived from uncontrolled clinical administration, it is believed pertinent to propose guidelines for the contemporary therapeutic use of albumin, an important plasma protein. The guidelines for this biologic are designed to assure appropriate use. Certain principles were followed in preparation of the recommendations. (1) It was believed that the selection of proper clinical circumstances for the therapeutic use of albumin should not be dictated by arbitrary or pragmatic restrictions but rather by the education of physicians in its normal physiologic function. (2) Although only a few specific disorders regularly require the use of albumin, a broad diversity of pathologic complications may justify its occasional use. (3) Many clinical disorders exist in which there is incomplete or conflicting data on the effectiveness of albumin therapy. (4) Still other disorders exist in
ASSOCIATION NEWS.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Why hasn't BCG proved dangerous in HIV-infected patients?
Authors: L. B. Reichman
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 1580: Genetic variability of H3K27me modifier genes<i>EZH2</i>,<i>KDM6A</i>and<i>KDM6B</i>in association with pancreatic cancer risk
Authors: Ye Lu, Ofure Obazee, Federico Canzian
Journal: Cancer Research (2019)

Abstract Background: Several literature reports explain the critical role of epigenetic regulation in relation to different types of cancers, however this is still an emerging research area in pancreatic cancer. Methylation of lysine 27 on histone H3 (H3K27me) plays a critical role in regulating gene expression and this modification has been reported to have oncogenic effects. Specifically, in pancreatic cancer this mechanism has only been demonstrated in relation to patient outcome. The demethylase KDM6A (UTX) or KDM6B (JMJD3, a paralog of KDM6A on a different chromosome), and methyltransferase EZH2 (KMT6A) specifically regulate the alteration level of H3K27me. Based on the hypothesis that genetic variants may influence overall gene function, it is plausible that single nucleotide polymorphisms (SNPs) in these genes may similarly affect the roles of these genes in H3K27me deregulation. Materials and methods: Using the SNPinfo tool, a total of 21 tag SNPs in EZH2, KDM6A and KDM6B were selected from European populations based on 1000 Genome project. SNPs below 80% linkage disequilibrium threshold or less than 5% frequency among Europeans were excluded. These SNPs were analysed in relation to pancreatic cancer susceptibility using logistic regression among up to 8,741 pancreatic cancer cases and 6,957 controls from publically-available GWAS data (Pancreatic Cancer Cohort Consortium (PanScan) and Pancreatic Cancer Case-Control Consortium (PanC4)). Imputation of these data sets were performed according to standard protocol and used for subsequent analyses. Results: Following adjustment for age and gender, we observed promising associations between KDM6B rs12453250 C&amp;gt;A and EZH2 rs2888566 T&amp;gt;C ((OR=0.92 95% CI (0.85-0.99), P=0.018) and (OR=1.09 95% CI (1.03-1.17), P=0.007) respectively) and pancreatic cancer risk. Interestingly, rs12453250 results in an amino acid change from Phenylalanine (F) to Leucine (L) which is predicted to have a probably-damaging effect on the KDM6B protein. Conclusions: The extent to which epigenetic markers can be incorporated into pancreatic cancer risk prediction along with genetic information is unknown. Our novel findings suggest a plausible role of EZH2 and KDM6A SNPs in relation to pancreatic cancer risk among carriers of their minor alleles. These results warrant further validation in independent studies and may enhance systematic risk assessment among Europeans. Citation Format: Ye Lu, Ofure Obazee, Federico Canzian. Genetic variability of H3K27me modifier genesEZH2,KDM6AandKDM6Bin association with pancreatic cancer risk [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1580.