tbuckley/cabot-search huggingface dataset:
Preliminary evidence points to affective disorder triggered by summer weather
Authors: C. A. Raymond
Journal: JAMA (1988)

COLD SHOWERS, long a folk medicine to lessen libido, may become part of therapy to restore sexual desire, positive thinking, and motivation lost to some persons suffering from depression, according to a preliminary study by investigators at the National Institute of Mental Health in Rockville, Md (<i>Am J Psychiatry</i>1987;144:1602-1603). The report adds to a growing body of evidence incriminating dysfunctions of energy regulation in the etiology of affective disorders. It also raises the possibility of simple, nonpharmacologic treatments—such as partial sleep deprivation (please see accompanying article on p 959), phototherapy, or changes in ambient temperature—for at least some of them. This line of research garnered attention by introducing the syndrome known as seasonal affective disorder: recurring winter depression. The syndrome has been known for nearly 70 years (Kraepelin E [Barclay RM (trans)], in Robertson GM, Livingstone E, Livingstone S [eds]:<i>Manic Depressive Illness and Paranoia</i>. Edinburgh, E &amp; S
Geriatrics
Authors: James Sowers
Journal: JAMA (1997)

The third edition of<i>Geriatric Medicine</i>represents a substantial updating of the second edition, especially in the areas of geriatric primary care and delivery of care. As in the preceding two editions, the editors and contributors represent a collection of outstanding geriatric academicians. The chapters have been written by experts in such areas as demographics of aging, urinary incontinence, dementia, delirium, syncope, cardiovascular disease, and cancer in the elderly. The new edition addresses to a greater extent than the prior two the practical aspects of rendering geriatric care. Most chapters include information on primary care of the geriatric patient in the home, outpatient clinic, emergency department, nursing home, and specialized geriatric inpatient facilities. This edition also addresses difficult and controversial issues especially as they relate to medical therapy for the terminal elderly, including palliative care.
Intra-aortic balloon counterpulsation. Refractory ventricular tachycardia
Authors: A. T. Culliford
Journal: JAMA (1978)

INTRA-AORTIC balloon counterpulsation (IABCP) is a useful adjunct in the treatment of patients with serious and decompensated cardiac disease. It has been used extensively as an intraoperative and postoperative aid in hemodynamically unstable patients. In addition, it is useful in treating patients with cardiogenic shock following myocardial infarction; however, there have been few reports of its successful use in the management of refractory cardiac arrhythmias. <h3>Report of a Case</h3> A 47-year-old man was admitted to the coronary care unit of another hospital with the complaint of retrosternal chest pain that had persisted for several hours. Serial enzyme determinations and ECGs established the diagnosis of acute anterior septal myocardial infarction. Shortly before discharge, he was awakened with constricting chest pain radiating to the neck. Serial ECGs showed extension of the infarction. Supraventricular tachycardia subsequently developed, which was readily controlled with edrophonium chloride. Recurrent bouts of ventricular tachycardia developed over the following
Public Health.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Belgian PCB and Dioxin Incident of January-June 1999: Exposure Data and Potential Impact on Health
Authors: Nik van Larebeke, Luc Hens, Paul Schepens, Adrian Covaci, Jan Baeyens, Kim Everaert, Jan L. Bernheim, Robert Vlietinck, Geert De Poorter
Journal: Environmental Health Perspectives (2001)

In January 1999, 500 tons of feed contaminated with approximately 50 kg of polychlorinated biphenyls (PCBs) and 1 g of dioxins were distributed to animal farms in Belgium, and to a lesser extent in the Netherlands, France, and Germany. This study was based on 20,491 samples collected in the database of the Belgian federal ministries from animal feed, cattle, pork, poultry, eggs, milk, and various fat-containing food items analyzed for their PCB and/or dioxin content. Dioxin measurements showed a clear predominance of polychlorinated dibenzofuran over polychlorinated dibenzodioxin congeners, a dioxin/PCB ratio of approximately 1:50,000 and a PCB fingerprint resembling that of an Aroclor mixture, thus confirming contamination by transformer oil rather than by other environmental sources. In this case the PCBs contribute significantly more to toxic equivalents (TEQ) than dioxins. The respective means +/- SDs and the maximum concentrations of dioxin (expressed in TEQ) and PCB observed per gram of fat in contaminated food were 170.3 +/- 487.7 pg, 2613.4 pg, 240.7 +/- 2036.9 ng, and 51059.0 ng in chicken; 1.9 +/- 0.8 pg, 4.3 pg, 34.2 +/- 30.5 ng, and 314.0 ng in milk; and 32.0 +/- 104.4 pg, 713.3 pg, 392.7 +/- 2883.5 ng, and 46000.0 ng in eggs. Assuming that as a consequence of this incident between 10 and 15 kg PCBs and from 200 to 300 mg dioxins were ingested by 10 million Belgians, the mean intake per kilogram of body weight is calculated to maximally 25,000 ng PCBs and 500 pg international TEQ dioxins. Estimates of the total number of cancers resulting from this incident range between 40 and 8,000. Neurotoxic and behavioral effects in neonates are also to be expected but cannot be quantified. Because food items differed widely (more than 50-fold) in the ratio of PCBs to dioxins, other significant sources of contamination and a high background contamination are likely to contribute substantially to the exposure of the Belgian population.
Incorrect Degree
Authors: Serena Ruggieri, Laura De Giglio
Journal: JAMA Neurology (2018)

Marco Savarese, PhD; Lorenzo Maggi, MD; Anna Vihola, PhD; Per Harald Jonson, PhD; Giorgio Tasca, MD; Lucia Ruggiero, MD; Luca Bello, MD; Francesca Magri, MD; Teresa Giugliano, PhD; Annalaura Torella, PhD; Anni Evilä, PhD; Giuseppina Di Fruscio, PhD; Olivier Vanakker, MD; Sara Gibertini, PhD; Liliana Vercelli, MD; Alessandra Ruggieri, MSc; Carlo Antozzi, MD; Helena Luque, BSc; Sandra Janssens, MD; Maria Barbara Pasanisi, MD; Chiara Fiorillo, MD; Monika Raimondi, MD; Manuela Ergoli, MSc; Luisa Politano, MD; Claudio Bruno, MD; Anna Rubegni, MD; Marika Pane, MD; Filippo M. Santorelli, MD; Carlo Minetti, MD; Corrado Angelini, MD; Jan De Bleecker, MD; Maurizio Moggio, MD; Tiziana Mongini, MD; Giacomo Pietro Comi, MD; Lucio Santoro, MD; Eugenio Mercuri, MD; Elena Pegoraro, MD; Marina Mora, PhD; Peter Hackman, PhD; Bjarne Udd, MD; Vincenzo Nigro, MD
Comparison of the acute cardiopulmonary effects of oral albuterol, metaproterenol, and terbutaline in asthmatics
Authors: J. D. Wolfe
Journal: JAMA (1985)

The acute cardiopulmonary effects of oral albuterol, 4 mg, metaproterenol sulfate, 20 mg, and terbutaline sulfate, 5 mg, were compared over eight hours in 20 moderate to severe asthmatics. The magnitude and time course of bronchodilation following albuterol and terbutaline were comparable. Albuterol and terbutaline had a duration of action of at least eight hours and produced significantly greater bronchodilation than metaproterenol from six to eight hours. Metaproterenol produced a greater degree of bronchodilation than albuterol and terbutaline 30 minutes after drug dosing. Significantly fewer patients receiving albuterol experienced one or more central nervous system or musculoskeletal side effects than patients receiving terbutaline. These findings imply possible therapeutic advantages of oral albuterol and terbutaline wifh respect to dosing frequency, while the more rapid onset of oral metaproterenol suggests that it may have an advantage when used on an as-needed basis. (<i>JAMA</i>1985;253:2068-2072)
Hormone secretion in alcohol-induced pseudo-Cushing's syndrome. Differential diagnosis with Cushing disease
Authors: S. W. Lamberts
Journal: JAMA (1979)

We describe the clinical and biochemical characteristics of alcoholinduced pseudo-Cushing's syndrome in two patients with signs and symptoms of Cushing's syndrome and slight disturbances in liver function. An insufficient suppression of plasma cortisol to the overnight administration of 1 mg of dexamethasone was accompanied by an absent diurnal rhythm of plasma cortisol and an increased cortisol secretion rate. The plasma cortisol levels at 8 AM normalized during hospital admission (ie, alcohol withdrawal) at the same rate or parallel with the serum 7-glutamyl transferase concentration. A normal increase of plasma cortisol, adrenocorticotropic hormone, and growth hormone in response to an insulin-induced hypoglycemia was not compatible with the diagnosis Cushing's syndrome. However, the result of a differential diagnostic test with metyrapone was compatible with the presence of Cushing's disease. An erroneous diagnosis of Cushing's disease can be easily made in patients with alcohol-induced pseudo-Cushing's syndrome. (<i>JAMA</i>242:1640-1643, 1979)
Neurology
Authors: William K. Jordan, H. Houston Merritt
Journal: New England Journal of Medicine (1959)

Cerebrovascular DiseaseTwo distinctly separate pathologic processes occur in brain tissue in cerebrovascular disease. These are infarction and hemorrhage. Increased emphasis has recently been placed, however, on the many different lesions that may occur in the vascular tree of the brain, the end result of which may be the occurrence of one or both of these parenchymal disturbances. It has been estimated that about forty different diseases affect the cerebrospinal blood vessels. The majority of cases of cerebrovascular disease appear to be related to hypertension and atherosclerosis. The ultimate solution to the larger part of this problem therefore appears to . . .
Thrombocytopenic Purpura in Toluene Di-Isocyanate Workers
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
What the double helix (1953) has meant for basic biomedical science. A personal commentary
Authors: J. Lederberg
Journal: JAMA (1993)

THE ARTICLE published by Watson and Crick in 1953<sup>1</sup>was the landmark pointer to our contemporary model of DNA as a macromolecular structure. This lay on a well-worn path of biophysical analysis, reducing microscopic anatomy to the molecular level. It also helped inspire an enormous body of biochemical research that has defined DNA as<i>the</i>informational molecule, a discontinuity that has been labeled the Biological Revolution of the 20th Century. As a piece of structural analysis, the idea of the double helix includes the concepts (1) that DNA is a duplex structure, comprising two paired complementary strands, associated by secondary, noncovalent bonds; (2) that the strand pairs are coiled, forming a double helix; and (3) that these are antiparallel—the orientation of one strand being in the opposite polarity from the other. The most novel features of DNA are associated with its duplicity, rather than its helicity. Linear polymers rarely
Single Coronary Artery
Authors: Amandus H. Sharbaugh
Journal: JAMA (1974)

Two of five cases of single coronary artery had additional cardiac anomalies. A review of the literature yielded 159 cases, 41% of which had additional cardiac anomalies. The presence of a single coronary artery without other cardiac defects (59%) was usually an innocuous finding. However, a small group of 13 cases without other anomalies were associated with sudden death or cardiomyopathy in young adulthood or childhood. Hence, we think that the presence of this anomaly is of prognostic importance, and that interest in it should be maintained. (<i>JAMA</i>230:243-246, 1974)
STUDENT LOAN FORBEARANCE CLARIFICATION
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Current Comment
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
431P First-line treatment of advanced nonsquamous non-small cell lung cancer (NSCLC) in China in the era of precision medicine
Authors: X. Zhang, Q. Zhou, Y. Song, G.Y. Chen, D.S. Zhong, Z. Yu, P. Yu, Y.P. Zhang, J.H. Chen, Y. Hu, G.S. Feng, X. Song, Q. Shi, L.L. Yang, P.H. Zhang, Y-L. Wu
Journal: Annals of Oncology (2016)
Inhalation Toxicology of Isoprene in F344 Rats and B6C3F 1 Mice Following Two-Week Exposures
Authors: Ronald L. Melnick, Joseph H. Roycroft, Billy J. Chou, Harvey A. Ragan, Rodney A. Miller
Journal: Environmental Health Perspectives (1990)

Isoprene (2-methyl-1,3-butadiene) was selected for toxicologic evaluations because of its structural similarity to 1,3-butadiene, a potent rodent carcinogen.Two-week inhalation toxicology studies of isoprene were conducted in F344 rats and B6C3F1 mice at exposure concentrations of 0, 438, 875, 1750, 3500, or 7000 ppm.For rats, there were no chemically related changes in survival, body weight gain, clinical signs, hematologic or clinical chemistry parameters, or gross or microscopic lesions.Exposure of mice to isoprene did not produce mortalities and only caused a decrease in body weight gain for male mice in the 7000 ppm exposure group; however, hematologic changes and microscopic lesions including testicular atrophy, olfactory epithelial degeneration, and forestomach epithelial hyperplasia were observed in isoprene-exposed mice.Similar toxicologic effects have been previously observed in B6C3F1 mice exposed to 1,3-butadiene.A species difference in susceptibility between rats and mice exposed to isoprene was evident in these short-term exposure studies.
Journal of Pathology and Bacteriology, London
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Time Course of Aortic Valve Function and Root Dimensions After Subcoronary Ross Procedure for Bicuspid Versus Tricuspid Aortic Valve Disease
Authors: Claudia Schmidtke, Matthias Bechtel, Michael Hueppe, Hans-H. Sievers
Journal: Circulation (2001)

Background The freestanding aortic root, which is the currently preferred operative technique for pulmonary autografts, is reported to dilate and potentially promote aortic insufficiency, which has led to a controversial debate on the appropriate surgical technique, especially for congenital bicuspid aortic valve disease. Desirable data on the time course of valve function and root dimensions for the alternative subcoronary technique comparing bicuspid and tricuspid aortic valve disease are scarce. Methods and Results Echocardiographic examinations of 31 patients with congenital bicuspid aortic valve disease (group A; age 50.5±11.0 years) and 51 patients with acquired tricuspid aortic valve disease (group B; age 48.1±15.7 years) who were operated on between June 1994 and August 1998 were performed twice postoperatively. At first and second follow-up, respectively, maximum (mean) pressure gradients were 6.0±2.0 (3.6±1.0) and 5.1±2.1 (2.9±1.1) mm Hg in group A and 6.5±3.5 (3.9±1.9) and 5.0±1.7 (2.9±1.0) mm Hg in group B ( P &gt;0.05 between groups). In group A, grade 0 aortic insufficiency at first and second follow-up occurred in 8 and 7 patients, respectively, grade 0-I in 12 and 9 patients, grade I in 9 and 11 patients, grade I-II in 1 and 0 patients, and grade II in 1 and 4 patients; in group B, grade 0 aortic insufficiency occurred in 16 and 18 patients, grade 0-I in 16 and 8 patients, grade I in 17 and 21 patients, grade I-II in 0 and 1 patient, and grade II in 0 and 1 patient ( P &gt;0.05). Aortic insufficiency decreased in 10 patients (17%). However, there was an overall tendency for aortic insufficiency to increase over time (n=23, 38%), although it remained subclinical. Aortic root dimensions did not differ between groups and were constant during follow-up. Conclusions This study provides some evidence that the function of the subcoronary pulmonary autograft in bicuspid aortic valve disease is excellent, with stable root dimensions, and is not different from that of tricuspid aortic valves at least up to 5.5 years postoperatively, which suggests the subcoronary technique should be reconsidered.
Board Examinations
Authors: N. Martinez de la Cotera
Journal: JAMA (1980)

<h3>To the Editor.—</h3> Since I read the letter entitled "Board Examinations" by Gil Hauer Santos, MD (243:120, 1980), I have been laughing. As an exiled Cuban physician who was never given that kind of examination until arriving in the United States, and passed with God's help, I completely agree with Dr Santos and many hundreds of other physicians for whom this senseless and obtuse examination is more hazardous to the mind than any illness. By the way, Dr Santos' satire was better than many I have read in<i>MAD</i>magazine, and his writing style reminds me of Mark Twain's. My congratulations, and I would like to see more contributions from Dr Santos to experience again the joyous moments that I had from reading his letter.