tbuckley/cabot-search huggingface dataset:
Nonmutagenic Mechanisms in Carcinogenesis: Role of Protein Kinase C in Signal Transduction and Growth Control
Authors: I. Bernard Weinstein
Journal: Environmental Health Perspectives (1991)

There is accumulating evidence that the multistage carcinogenic process is associated with the progressive acquisition of mutations in cellular proto-oncogenes and in growth-suppressor genes. At the same time, several types of evidence indicate that nongenotoxic agents and epigenetic events also play an important role in the evolution of tumors. One of the most intensively studied nongenotoxic agents is the phorbol ester tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA) and related compounds. Since TPA appears to exert its biologic effects through protein kinase C (PKC), a key enzyme in signal transduction, we have studied this enzyme in considerable detail. Our strategy has been to perturb signal transduction by developing cell lines that overexpress the beta 1 isoform of PKC. Such derivatives of rat fibroblasts display alterations in morphology and growth factors, altered expression of c-myc, ornithine decarboxylase, and phorbin, and increased susceptibility to transformation by certain oncogenes, H-ras, myc, and fos. These findings provide direct genetic evidence that PKC plays a critical role in growth control and the action of certain growth factors, tumor promoters, and oncogenes. In related studies, we have characterized the beta 1 isoform that is overproduced in the above cell systems in terms of its biochemical, kinetic, and immunologic properties. The enzyme has several properties characteristic of native PKCs. A surprising finding is that c-H-ras-transformed derivatives of the cells that overexpress PKC beta 1 display a several-fold increase in the expression of the endogenous alpha 1 isoform of PKC and a decrease in the expression of the endogenous epsilon isoform.(ABSTRACT TRUNCATED AT 250 WORDS)
Educating medical educators
Authors: C. G. Kardinal
Journal: JAMA (1968)

<h3>To the Editor:—</h3> I have been following your series of papers on medical writing, but I doubt that these articles will have much effect on improving the quality and clarity of clinical manuscripts. The problem seems more basic than one that can be solved by writing lessons. Yes, clinical papers are laiden with clichés, do lack style, and are burdened with long cumbersome sentences. And yes, they are forced to adhere to the introduction, methods, results, and discussion (IMRAD) form (<i>Ann Intern Med</i><b>67</b>:1117, 1967) which makes redundancy in expression inescapable. But I think a physician's ability or inability to express himself clearly in technical writing relates directly to his ability or inability to express himself in terms of thought content and speech. This in turn relates to his understanding not only of scientific discourse but also to his understanding of the arts, viz, literature, logic, and rhetoric. The
Transvenous retrieval of foreign bodies in the cardiac circulation
Authors: P. C. Block
Journal: JAMA (1973)

A series of six patients had foreign bodies (sheared or broken intravenous lines) lying free in the circulation. "Nonsurgical" transvenous removal was accomplished successfully using a wire snare. Sites of foreign body embolism and subsequent removal included the superior vena cava, the right atrium, the right ventricle, and the pulmonary artery.
MANIFESTATIONS OF OLD AGE
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Kidney transplantation under FK 506
Authors: T. E. Starzl
Journal: JAMA (1990)

The experimental immunosuppressive drug FK 506 was given to 36 renal transplant recipients, many of whom were highly sensitized.Ten were undergoing kidney retransplantation, 10 also underwent liver transplantation at an earlier time (6 patients) or concomitantly (4 patients), and 2 patients received a third organ (heart or pancreas) in addition to a liver and kidney.With follow-ups of 4 to 13 months, all but 2 of the 36 patients are alive, 29 (81 %) are dialysis free, and most have good renal function.Twenty of the 29 dialysis-free patients are receiving no or low-dose (2.5 to 5.0 mg/d) prednisone therapy.Only one kidney was lost to cellular rejection.However, patients who had antidonor cytotoxic antibodies in current or historical serum samples had a high rate (3 of 9) of irreversible humoral rejection.A low incidence of posttransplant hypertension was noteworthy.Hirsutism and gingival hyperplasia were not observed.Serum cholesterol levels in patients who took FK 506 were unexpectedly low, and the effect on the level of uric acid was minimal.The side effects of FK 506 therapy include nephrotoxicity, neurotoxicity, and potential induction of a diabetic state.These are similar to the side effects of cyclosporine use, but probably less severe.The seeming safety, efficacy, and relative freedom from side effects of FK 506 encourage further trials in kidney transplantation.
Letter: Pancuronium tachycardia
Journal: JAMA (1973)

<h3>To the Editor.—</h3> In reference to the letter by Orkin and Pegg (224:630, 1973), we want to emphasize that in our study,<sup>1</sup>specially designed to evaluate the circulatory effects of pancuronium, namely, its influence on electrocardiograms, blood pressure, plasma free-epinephrine and norepinephrine concentrations in combination with blood gases, less than 10% elevations of the heart rate and blood pressures were observed, and no rise in plasma catecholamines. These findings are further corroborated by the lack of increase in heart rate, blood pressure, and in catecholamines when pancuronium, 0.09 mg/kg of body weight, was followed by ketamine hydrochloride, 2.0 mg/kg, and these were administered to good-risk, young, gynecologic patients in our study. Evidently, pancuronium blocked the development of tachycardia, hypertension, and the rise in plasma free-norepinephrine caused otherwise by ketamine, 2.0 mg/kg, intravenously administered in our previous study.<sup>2</sup> Therefore, we routinely utilized 0.08 mg/kg pancuronium for facilitation of intubation
Correction: The eye and the nervous system
Journal: BMJ (1988)

with summary bias equal to -0-0003.Sample variances ranged between 0-000 and 0-023 with a summary variance of 0 006.The summary estimate of mean square error was 0 007.Thus, the estimated bias, variance, and mean square error of the power estimates were small.All users correctly determined power within 5% of the true power in eight or more of the 11 examples, with a 90% overall rate of correct determina- tions.Eight of the 17 participants correctly determined power for all examples.After the evaluation the graphs were refined using computer plotting with improved scaling of the abscissa, which should enhance the accuracy of the aid.
A Topical Agent for the Treatment of Superficial Fungal Infections of the Skin
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Coagulation factor V levels as a prognostic indicator in fulminant hepatic failure
Authors: S Izumi
Journal: Hepatology (1996)

Data reported by Bernuau et al. have strongly supported the measurement of coagulation factor V as the best prognostic indicator in fulminant hepatic failure (FHF) and as the test on which selection for urgent liver transplantation should be made. In this study, we have measured plasma factor V in 110 patients with FHF, in grades I-IV coma, in 88 of whom the etiology was acetaminophen overdose. On admission, patients who did not survive had significantly lower factor V levels (median, 5%; range, 1-27; n = 49), compared with those who did (median, 10%; range, 2-70; P < .001). In the 81 patients with acetaminophen-induced FHF who did not receive a transplant, there was no cutoff level of factor V that clearly separated the patients. On statistical analysis, a positive predictive value (the mortality in patients predicted to have a poor prognosis) of 0.49 was calculated for factor V <20% and 0.57 for factor V < 10%. If the prognostic criteria included deep coma (grades III and IV) as well as factor V <20%, a positive predictive value of 0.73 was calculated. This compared with a value of 0.92 for the well-established King's prognostic criteria based on pH, and a combination of international normalized ratio (INR), renal failure, and coma. In the 17 mixed, nonacetaminophen group of patients who did not receive a liver graft, the positive predictive value was 0.85 for a factor V level <20% and 1.00 for factor V <10%, compared with 0.93 for the King's criteria for that etiologic group. This study demonstrates that the predictive accuracy of plasma factor V level is much less effective than the well-validated King's criteria in the selection of patients with acetaminophen-induced FHF needing liver grafting, although it may be useful in patients with FHF due to other causes.
New Viral Exanthems.
Authors: A Martin Lerner
Journal: Annals of Internal Medicine (1964)

s1 February 1964New Viral Exanthems.A Martin Lerner, M.D.A Martin Lerner, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-2-328_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe common viral exanthems (measles, rubella, chicken pox, and herpes simplex) have been known to clinicians for as many as 200 years. However, many eruptions (particularly of childhood) have defied specific diagnosis. Descriptive phrases such as "fourth, fifth, or sixth diseases" have served little purpose. The new technology in virology has allowed isolation of previously unrecognized agents coupled with careful observation of patients and their controls. At this time five new illnesses with rash are known, which in the typical case can be recognized at the bedside. These are: (1) ECHO-9 exanthem; (2) Boston exanthem (ECHO-16); (3) vesicular stomatitis with... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Detroit, Michigan PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1964Volume 60, Issue 2_Part_1Page: 328-328KeywordsChickenpoxHerpes simplexMeaslesRashesRubellaVirology Issue Published: 1 February 1964 PDF downloadLoading ...
The Common Neuroses: Their Treatment by Psychotherapy.
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction
Journal: Circulation (2016)

Impact of DM on Clinical EventsDuring the first 12 months after PCI, death (1.9% versus 1.0%), MI (4.0% versus 2.2%), stent thrombosis (0.8% versus 0.4%), stroke (1.3% versus 0.6%), and moderate or severe bleeding (3.3% versus 2.4%, all P≤0.001) rates were higher among enrolled patients with DM than in enrolled patients without DM, respectively.
ECDC guidance on prevention of HIV and STIs suggests seven components for inclusion in national EU/EEA public health programmes
Journal: Eurosurveillance (2015)

Preview this article: ECDC guidance on prevention of HIV and STIs suggests seven components for inclusion in national EU/EEA public health programmes, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/20/25/art21168-en-1.gif
Observations on Atrial Sound in Hypertension
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Giardiasis. A cause of traveler's diarrhea
Authors: R. R. Babb
Journal: JAMA (1971)

Of 70 patients with giardiasis, 58 (83%) had been traveling outside of the United States when symptoms began. Characteristic complaints consisted of nausea, weight loss, abdominal cramps, and diarrhea with nonbloody stools. No abnormalities in blood counts or in results of liver function tests or large-bowel studies were found. Two of three patients who underwent barium sulfate examinations of the small bowel showed abnormalities, and one who underwent a peroral small-bowel biopsy showed marked inflammation.<i>Giardia lamblia</i>can be pathogenic in man, and treatment with quinacrine hydrochloride is very effective.
Incorrect Signature
Journal: JAMA (1976)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical Lectures: DELIVERED IN ST. BARTHOLOMEW'S HOSPITAL, LONDON
Authors: F. C. Skey
Journal: BMJ (1856)

me most valuable assistance and advice during the opera- tion.The hernial tumour was ovoid in shape, large and tense, and reflected over Poupart's ligament.I transfixed the integument with a long straight knife, and made the usual T shaped incisions.The superficial fascia and fascia propria were very thin, and required great care in dividing them.The sac was now fully exposed, of a very, dark colour, and so extremely tense, that I could not make out by the touch what were its contents.I then felt for the
Epidemiologists aim at new target: health risk of handgun proliferation
Authors: M. F. Goldsmith
Journal: JAMA (1989)

"HOMICIDE is not a disease, but it is a public health condition whose primary cause is possession of guns—and it could be considered an epidemic because of the high incidence in certain populations," recently said Paul Stolley, MD, president of the American College of Epidemiology, announcing that group's first policy statement calling for research on the effects of handgun control. "Nonsense!" says Paul H. Blackman, PhD, research coordinator of the National Rifle Association (NRA). "Epidemics are things that are catching, and gun ownership and use aren't catching. Calling something an epidemic doesn't make it an epidemic. That's typical of gun control people's shoddy thinking." The battle between those who favor and those who abhor regulation of gun ownership and use was joined years ago, but it's been heating up lately as medical authorities have begun to examine the relationship of guns and injury from the viewpoint of public health rather
DXplain
Authors: G. Octo Barnett
Journal: JAMA (1987)

DXplain is an evolving computer-based diagnostic decision-support system designed for use by the physician who has no computer expertise. DXplain accepts a list of clinical manifestations and then proposes diagnostic hypotheses. The program explains and justifies its interpretations and provides access to a knowledge base concerning the differential diagnosis of the signs and symptoms. DXplain was developed with the support and cooperation of the American Medical Association. The system is distributed to the medical community through AMA/NET—a nationwide computer communications network sponsored by the American Medical Association—and through the Massachusetts General Hospital Continuing Education Network. A key element in the distribution of DXplain is the planned collaboration with its physician-users whose comments, criticisms, and suggestions will play an important role in modifying and enhancing the knowledge base. (<i>JAMA</i>1987;258:67-74)
Abstract 17230: Respiratory Sinus Arrhythmia Quantified from Standard ECG for Risk Stratification of Post-Infarction Patients
Authors: Daniel Sinnecker, Petra Barthel, Alexander Müller, Karl-Ludwig Laugwitz, Georg Schmidt
Journal: Circulation (2014)

Objectives: Respiratory sinus arrhythmia (RSA) reflects modulation of the sinoatrial node discharge frequency by the autonomic nervous system. Impaired autonomic function is associated with adverse outcome in cardiac patients. We developed a method for calculating RSA from standard ECG recordings and investigated its association with mortality in survivors of acute myocardial infarction. Methods: Consecutive patients (n=941, mean age 61 years, 19% female) presenting with acute myocardial infarction and sinus rhythm were enrolled between May 2000 and March 2005 and followed up until August 2010. The main study outcome was 5-year all-cause mortality. Patients underwent 30-minute ECG recordings. Auxiliary respiratory muscle activity derived from high pass-filtered ECG signal was used to define respiratory phase. The influence of expiration on RR intervals (RRI) was assessed by bivariate phase-rectified signal averaging (PRSA), and RSA PRSA was quantified by Haar wavelet analysis. RSA PRSA ≤0 was defined as abnormal. Results: During the follow-up, 72 patients died. Five-year mortality rates in patients with normal and abnormal RSA PRSA were 4% and 14%, respectively. Under univariable analysis, RSA PRSA was a significant predictor of death (p&lt;0.001), as were GRACE score (p&lt;0.001), LVEF (p&lt;0.001), and the presence of diabetes mellitus (p&lt;0.001). Under multivariable analysis, RSA PRSA , GRACE score, LVEF, and diabetes mellitus were independently and significantly associated with outcome. Conclusions: Respiratory sinus arrhythmia, quantified by bivariate PRSA from standard ECG recordings, is an independent predictor of mortality risk in post-infarction patients.
BUENOS AIRES
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal