tbuckley/cabot-search huggingface dataset:
THE PURE FOOD QUESTION.
Journal: JAMA (1905)

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Pulmonary manifestations of Behçet's disease
Authors: F Erkan, A Gül, E Tasali
Journal: Thorax (2001)

HistoryBehçet's disease is a chronic inflammatory disorder of unknown aetiology characterised by recurrent attacks.8][9][10] Diagnosis Since Behçet's disease does not have pathognomonic symptoms or laboratory findings, the diagnosis is made on the basis of the criteria proposed by the International Study Group for Behçet's disease in 1990 (table 2). 11According to the criteria, recurrent oral ulceration must be present and at least two of the following: recurrent genital ulceration, eye lesions, skin lesions, or a positive pathergy test (development of a papule or pustule following a needle prick to the skin, as in table 2). Epidemiology3][14][15][16][17][18] The highest prevalence rate was reported from Turkey as 80-370 per 100 000.The prevalence ranges from two to 30 cases per 100 000 in
Deaths and Obituaries.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
HFE mutations and chronic hepatitis C: H63D and C282Y heterozygosity are independent risk factors for liver fibrosis and cirrhosis
Authors: A. Erhardt, A. Maschner-Olberg, C. Mellenthin, G. Kappert, O. Adams, A. Donner, C. Niederau, D. Haeussinger
Journal: Journal of Hepatology (2003)
银屑病中严重感染的风险预测模型
Authors: Z.Z.N. Yiu, C. Sorbe, M. Lunt, S.J. Rustenbach, L. Kühl, M. Augustin, K.J. Mason, D.M. Ashcroft, C.E.M. Griffiths, R.B. Warren
Journal: British Journal of Dermatology (2019)

这项研究由一组来自曼彻斯特和汉堡的皮肤科研究者执行。它使用来自德国银屑病登记数据库和英国皮肤病学会生物干预登记数据库(或 BADBIR,旨在采集用于银屑病的新型生物制剂相关使用和结局的信息)的信息。该团队开发并评估了一个模型,用于预测哪些银屑病患者最可能在开始系统接受治疗(即作用于全身的治疗,而非只是外用于皮肤上)后一年内发生严重感染。评估的治疗范围包括从口服药物的老方法(如甲氨蝶呤或环孢素)到较新的注射生物制剂治疗(如依那西普或优特克单抗)。评估小组就待调查的潜在风险因素(如年龄、性别、疾病严重程度和初始治疗以及其他)达成了一致。这类严重感染是指在患者开始这些治疗后一年内导致患者长时间住院、接受抗生素静脉注射治疗或者死亡的感染。1.7% 的 BADBIR 和德国患者发生了重度感染。严重感染可能性增高的风险因素包括性别为女性、其他潜在疾病(如慢性肺病)、酒精摄入较多和接受生物制剂利妥昔单抗治疗。令人感兴趣的是,年龄本身不会导致感染风险增高。这项研究将被证实极其有助于帮助皮肤科医生决定治疗哪些患者、使用何种药物,以及就饮酒等生活方式选择为患者提供建议。
The Role of Fat and Calcium in the Production of Foci of Aberrant Crypts in the Colon of Rats Fed 2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]-Pyridine
Authors: John H. Weisburger, Joanne Braley, Joel Reinhardt, Cesar Aliaga, Abraham Rivenson, Gordon C. Hard, Xue-Ming Zhang, Mami Takahashi, Hiroyasu Esumi, Takashi Sugimura
Journal: Environmental Health Perspectives (1994)

The modulation by dietary fat levels of intestine carcinogenesis is well documented.New developments suggest that calcium ions may also play a role.A rapid bioassay, the induction of foci of aberrant crypts in the colon, was used to explore the interaction between dietary fat and calcium.Male F344 rats 6 weeks of age were placed on diets containing 5 or 20% corn oil, and 0.04 or 0.32% calcium ion, as calcium lactate.Each dietary group was fed 400 ppm 2-amino-i-methyl-6-phenylimidazo[4,5-blpyridine (PhIP), and negative controls received the diets alone.A positive control group was given 2 mg N-nitrosomethylurea (NMU) intrarectally four times in a 2-week period.All rats were killed after 9 weeks.The intestinal tract was rinsed with Krebs-Ringer buffer.After staining a 6-cm segment of the descending colon and rectum with 0.2% methylene blue, foci of aberrant crypts were evaluated microscopically.With PhIP as a carcinogen, the rats on a high-fat, low-calcium level had more foci of aberrant crypts than animals on a low-fat level.With the higher calcium level, there were fewer foci and aberrant crypts, but the effect of fat was still significant.With NMU and a low-calcium level, the effect of fat level was evident.However, with the higher calcium intake, there were considerably more foci of aberrant crypts than on the low-calcium level, and the effect of the dietary fat level was not obvious.Thus, with the dietary carcinogen PhIP, an enhancing effect of high fat intake and a protective effect of a higher calcium intake on the induction of intestinal foci of aberrant crypts could be visualized in a 9-week test.With limited intrarectal administration of NMU, the association with dietary fat was evident on a low-calcium intake.On a high-calcium intake, there was a considerably higher number of aberrant crypt foci, perhaps because of the more advanced carcinogenic process with NMU.-Environ Health Perspect 1 02(Suppl 6): 53-55 (1994) Key words: food carcinogens
CHLORIDE IN DIABETIC ACIDOSIS
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Experimental Method for the Study of Aortic Insufficiency
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Corrections
Authors: Hedley Atkins, Peter Medawar, A Heath, B Rau, Hcdley Atkins, L Pyrah, Mr Edwards, Mr Eyre-Brook, Mr Lawrie, Mr Nevin, St Thomas, M Jenkins, E Soares, H Poulsen, I Zhorov, J Lincoln, Otology.-A Adhya, J Barker, T Baruah, D Berzon
Journal: BMJ (1968)
Prognostic index for recurrence of seizures after remission of epilepsy. Medical Research Council Antiepileptic Drug Withdrawal Study Group.
Authors: D Chadwick
Journal: BMJ (1993)

OBJECTIVES--To develop and test a prognostic index for the recurrence of seizures after a minimum remission of seizures of two years in people with a history of epilepsy. DESIGN--Information from a large prospective randomised study of withdrawal of antiepileptic drugs was used to identify clinical and treatment factors of prognostic importance in determining the recurrence of seizures. A split sample approach was used to test the internal validity of predictions made on the basis of identified prognostic factors. SETTING--Centres in six European countries. MAIN OUTCOME MEASURES--Comparison of predicted and observed rates of recurrence of seizure. SUBJECTS--1013 patients randomised to the Medical Research Council study for antiepileptic drug withdrawal. RESULTS--The Cox proportional hazards model identified several factors that increased the risk of seizures recurring. These included being 16 years or older; taking more than one antiepileptic drug; experiencing seizures after starting antiepileptic drug treatment; a history of primary or secondarily generalised tonic-clonic seizures; a history of myoclonic seizures; and having an abnormal electroencephalogram. The risks of seizures recurring decreased with increasing time without seizures. The model allowed estimation of the risk of seizures recurring in the next one and two years under the policies of continued antiepileptic drug treatment and slow withdrawal of drugs. Split sample validation suggested that the model was well calibrated. CONCLUSION--The model is currently the best available aid for counselling the many patients in the community with epilepsy currently in remission who seek advice about the risks of seizures recurring if they stop antiepileptic drug treatment. The model requires validation in a broad population of patients, and such studies are in progress.
A Practical Medical Dictionary of Words Used in Medicine with Their Derivation and Pronunciation, Including Dental, Veterinary, Chemical, Botanical, Electrical, Life Insurance and Other Special Terms; Anatomical Tables of the Titles in General Use, the Terms Sanctioned by the Basle Anatomical Convention and Those Suggested by the Nomenklatur-Kommission; Pharmaceutical Preparations, Official in the U. S. and British Pharmacopœias and Contained in the National Formulary, and Comprehensive Lists …
Journal: JAMA (1934)

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Reply
Authors: D C Carter
Journal: Gut (1986)

Effect of cimetidine and omeprazole on aspirin and taurocholate-induced gastric mucosal damage SIR,-The study by Utley et al (Gut 1985; 26: 770-5) concludes that cimetidine, but not omeprazole can protect the pylorus ligated rat against gastric mucosal injury induced by topical aspirin or tauro- cholate.These conclusions are not strictly valid, because the gastric mucosal injury was only assessed macroscopically.If a study is designed to investigate and compare the cytoprotective qualities of two drugs, then surely a histological assessment of the gastric mucosal injury is mandatory.The omission of histology in the earlier studies by
Apnea Test
Authors: Gregory L. Repass
Journal: Annals of Internal Medicine (2014)

Ad Libitum21 January 2014Apnea TestGregory L. Repass, MDGregory L. Repass, MDFrom Jacksonville, Florida.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M13-0803 Audio Reading - “Apnea Test” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Apnea Test," by G.L. Repass. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail A relationship that began with the platitude“No words” stood fading;Ceremoniously hostage to a crisp, stapled protocolWith discrete instructionsPurported to define “brain death.”Unfeeling criteria to exclude human lifeThat a room, and hallway, full of loved ones were poised to contradict with Extemporaneous anecdoteTo describe “brain life.”Tubes and lines dematerializing as polite conversation mimicked testimonyOf home-cooked gourmet meals and hockey lessons to a step-son,A loving companion,A boisterous promoter of “the good life”Who lay still.Purpose returned with the departure of the anxious fatherAs memory succumbed to vigilance.My eyes scanning without seeingThe mechanical monitors and pumps,Escaping without acknowledgingThe earnest, hopeful glances.... Author, Article, and Disclosure InformationAffiliations: From Jacksonville, Florida.Current Author Address: Gregory L. Repass, MD; e-mail, greg.[email protected]com. PreviousarticleNextarticle Advertisement Audio Reading - “Apnea Test” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Apnea Test," by G.L. Repass. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 21 January 2014Volume 160, Issue 2Page: 139KeywordsApneaBrainHeartMemoryThorax ePublished: 21 January 2014 Issue Published: 21 January 2014 CopyrightCopyright © 2014 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Maternal-infant transmission of hepatitis C virus infection
Authors: Eve A. Roberts, Latifa Yeung
Journal: Hepatology (2002)

Mother-to-infant transmission of hepatitis C virus (HCV) is comparatively uncommon. The prevalence of antibody to HCV (anti-HCV) in pregnant women is 0.1% to 2.4%, although in some endemic areas it is much higher. The proportion of women with anti-HCV who have active infection with viremia is 60% to 70%. Transmission of HCV occurs only when serum HCV RNA is detectable and may be related to higher levels (above 10 6 copies per mL). The rate of mother-to-infant transmission is 4% to 7% per pregnancy in women with HCV viremia. Co-infection with human immunodeficiency virus (HIV) increases the rate of transmission 4 to 5 fold. The actual time and mode of transmission are not known. Elective Cesarean section is not recommended for women with chronic HCV infection alone. The role of treatment to prevent transmission is limited by the fetal toxicity of currently available medications for hepatitis C. Breast feeding poses no important risk of HCV transmission if nipples are not traumatized and maternal hepatitis C is quiescent. Pregnant women at high risk for HCV infection should be screened for anti-HCV, and HCV RNA testing should be performed if anti-HCV is positive. Infants of women with hepatitis C should be tested for HCV RNA on two occasions, between the ages of 2 and 6 months and again at 18 to 24 months, along with serum anti-HCV. The natural history of mother-to-infant hepatitis C remains uncertain, especially the course in the first year of life when some infants appear to have spontaneous resolution. (Hepatology 2002;36:S106-S113).
Top Executives
Authors: E. C. Livingston
Journal: BMJ (1959)

<h3>Introduction</h3> Dilated Cardiomyopathy is an important cause of heart failure in children. It often has an idiopathic aetiology, but may also be caused by infection and can be inherited. Hypocalcaemia is a rare but important reversible cause of dilated cardiomyopathy. Vitamin D deficiency is the main cause of hypocalcaemia in almost all reported cases. <h3>Case Report:</h3> An 8 month-old, Afro-Caribbean boy, presented with acute heart failure and respiratory distress. He was born in the UK and exclusively breastfed until 6 months of age. Cardiovascular examination revealed a gallop rhythm and a grade 2/6 pan systolic murmur at the apex, with a 2cm liver edge palpable. There was clinical evidence of rickets. Investigations included a chest X-ray, which showed cardiomegaly and plethoric lung fields. ECG showed increased left ventricular voltages and a prolonged QTc interval. Venous blood gas revealed a metabolic acidosis and a low ionised calcium level (0.6mMol/l). Echocardiogram revealed a poorly functioning and dilated left ventricle with severe mitral regurgitation. Hypocalcaemia secondary to severe vitamin D deficiency was diagnosed by screening blood tests. In addition to supportive treatment for cardiac failure (furosemide and captopril) he was treated with alphacalcidiol and Calcium-Sandoz. Echocardiogram 2 months later showed a near normal left ventricular function with a well contracting ventricle. His biochemical profile normalised within 4 weeks of treatment. <h3>Discussion</h3> Nutritional vitamin D deficiency leading to dilated cardiomyopathy has been increasingly reported, and indicates it as an important aetiology to consider in heart failure. A recent retrospective review showed that such infants can present in extremis, requiring inotropic and ECMO support. However, compared to other cardiomyopathies, there is a relatively good prognosis, with a mean recovery of left ventricular shortening reported at 12.4 months.<sup>1</sup> Rickets itself has seen a resurgence, especially in developed countries<sup>2</sup> This is a preventable condition, but obstacles<sup>3,4</sup> have been reported, despite NICE<sup>5</sup> and DoH<sup>6</sup> guidelines for antenatal care, post-natal supplementation and clinical management. <h3>Conclusion</h3> This case represents a serious consequence for undiagnosed vitamin D deficiency. In view of its preventable nature, healthcare professionls should have greater awareness. This has been supported by the recent RCPCH position statement calling for practical sign-posting.<sup>7</sup>
Leads from the MMWR. Premature mortality due to malignant neoplasms--United States, 1983
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Annals of Allergy, Boston
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Journal of Pediatrics, St. Louis
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal