tbuckley/cabot-search huggingface dataset:
Menders of the Maimed: The Anatomical &amp; Physiological Principles Underlying the Treatment of Injuries to Muscles, Nerves, Bones, &amp; Joints
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mass intervention vs screening and selective intervention for the prevention of coronary heart disease
Authors: R. E. Olson
Journal: JAMA (1986)

IN THE April 12 issue of<i>JAMA</i>, the statement of the National Institutes of Health (NIH) Consensus Development Conference on "Lowering Blood Cholesterol to Prevent Heart Disease" was published<sup>1</sup>together with three related articles. The key recommendation of the consensus conference was that all individuals in this country beyond the age of 2 years should be advised to follow fat-modified diets in the interest of preventing coronary disease regardless of their sex, their age, or the presence of other risk factors. <h3>Report on Educational Initiative to Lower Lipid Levels</h3> The first related article<sup>2</sup>was a discourse on a national educational initiative to lower plasma lipid levels in the entire population by Drs William R. Harlan and Jeoffrey K. Stross. In agreeing with the Consensus Panel, these authors proposed that it is time now to launch a massive education program for professionals and the public regarding the benefits of
Implications for Risk Assessment of Suggested Nongenotoxic Mechanisms of Chemical Carcinogenesis
Authors: Ronald L. Melnick, Michael C. Kohn, Christopher J. Portier
Journal: Environmental Health Perspectives (1996)

Nongenotoxic carcinogens are chemicals that induce neoplasia without it or its metabolites reacting directly with DNA.Chemicals classified as nongenotoxic carcinogens have been assumed to act as tumor promoters and exhibit threshold tumor dose-responses.This is in contrast to genotoxic carcinogens that are DNA reactive, act as tumor initiators, and are assumed to exhibit proportional responses at low doses.In this perspective, we examine the basic tenets and utility of this classification for evaluating human cancer risk.Two classes of so-called nongenotoxic chemical carcinogens selected for review include cytotoxic agents that induce regenerative hyperplasia (trihalomethanes and inducers of a2-microglobulin nephropathy) and agents that act via receptor-mediated mechanisms (peroxisome proliferators and dioxin).Major conclusions of this review include: a) many chemicals considered to be nongenotoxic carcinogens actually possess certain genotoxic activities, and limiting evaluations of carcinogenicity to their nongenotoxic effects can be misleading; b) some nongenotoxic activities may cause oxidative DNA damage and thereby initiate carcinogenesis; c) although cell replication is involved in tumor development, cytotoxicity and mitogenesis do not reliably predict carcinogenesis; d) a threshold tumor response is not an inevitable result of a receptor-mediated mechanism.There are insufficient data on the chemicals reviewed here to justify treating their carcinogenic effects in animals as irrelevant for evaluating human risk.Research findings that characterize the multiple mechanisms of chemical carcinogenesis should be used quantitatively to clarify human dose-response relationships, leading to improved scientifically based public health decisions.Excessive reliance on oversimplified classification schemes that do not consider all potential contributing effects of a toxicant can obscure the actual causal relationships between exposure and cancer outcome.
Clinical Convention To Offer Varied Scientific Program, Medical Forum
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Forensic Medicine
Authors: David M. Spain
Journal: JAMA (1966)

In the opening chapter there are brief reviews of the medical-legal systems of England entitled "The Colonial System," "The European Medical-Legal System," and "The Medical Examiners System of the United States and of the Australian States." These reviews are brief but informative and should prove valuable to those who are still trying to institute modern medical examiner systems where they do not exist in this country. Despite the fact that the legal code is not exactly the same in Australia as it is in the United States, there is still much that can be learned from those sections that deal with registration of deaths, burial, cremation, professional responsibility, liability, and negligence. The chapter on sudden death from natural causes presents statistics comparable to those seen in this country, although sudden death from coronary atherosclerosis is a more important cause in the United States. It was interesting to note that among
"RELATIONSHIP BETWEEN AIRWAY NARROWING, PATCHY VENTILATION AND LUNG MECHANICS IN ASTHMATICS". N.T. TGAVALEKOS, G. MUSCH, R.S. HARRIS, M.F. VIDAL MELO, T. WINKLER, T. SCHROEDER, R. CALLAHAN, K.R. LUTCHEN AND J.G. VENEGAS. EUR RESPIR J 2007; 29: 1174 1181.
Journal: European Respiratory Journal (2007)
Treatment without consent: emergency. By our legal correspondent.
Journal: BMJ (1985)

A brief overview of the legal aspects of emergency care in England is provided by the British Medical Journal's legal correspondent. Since little case law exists in this area, the author offers guidance on how far a doctor might go in treating without consent by suggesting how a physician's actions in various circumstances might be viewed by the courts. Among the emergency situations described are those of unconscious adults or children who are unable to give consent, unconscious adults or children whose family members refuse treatment, and patients who consent to surgery for one condition but then present on the operating table with an additional ailment requiring treatment.
FIRST REPORT OF A SECONDARY AORTO-JEJUNAL FISTULA DIAGNOSED BY DOUBLE-BALLOON ENTEROSCOPY
Authors: A Murino, N Koukias, A Telese, N Lazaridis, EJ Despott
Journal: Endoscopy (2018)

Aorto-jejunal fistula (AJF) is a very rare, life threatening condition which may result in catastrophic gastrointestinal (GI) bleeding. Secondary AJF is usually associated with a history of previous surgical repair of an abdominal aortic aneurysm (AAA).
Gene Expression Analysis Uncovers Similarity and Differences Among Burkitt Lymphoma Subtypes
Authors: Pier Paolo Piccaluga, Giulia De Falco, Manjunat Kustagi, Anna Gazzola, Annalisa Astolfi, Claudio Agostinelli, Eleonora Leucci, Anna Onnis, Claudio Tripodo, maria Rosaria Sapienza, Cristiana Bellan, Stefano Lazzi, Lynnette Tumwine, Michael Mawanda, Martin Ogwang, Valeria Calbi, Serena Formica, Andrea Califano, Stefano Pileri, Lorenzo Leoncini
Journal: Blood (2010)
Nontraumatic mediastinitis
Authors: R. W. Enquist
Journal: JAMA (1976)

ACUTE mediastinitis is distinctly uncommon; when it occurs, it usually follows an esophageal perforation or median sternotomy incision during open heart surgery. Nontraumatic causes include infections of the upper respiratory tract, infections of the lung and pleura, subphrenic infections, vertebral and rib osteomyelitis, and metastatic infections. These latter conditions may initially present as acute mediastinitis, requiring prompt and vigorous treatment as well as a thorough search for the underlying cause. This communication describes a case of nontraumatic acute mediastinitis and reviews the literature pertaining to the bacteriologic spectrum and treatment of mediastinitis of nontraumatic origin. <h3>Report of a Case</h3> A 64-year-old man in previously good health had the onset of fever, myalgia, sore throat, and malaise. Three days later, because persistent substernal chest pain developed, he was seen as an outpatient and pharyngitis was noted. His chest roentgenogram and complete blood cell count were unremarkable. No cultures were done, and
<i>Erratum:</i> Vol. 68, No. 45
Authors: Benjamin C. Blount, Mateusz P. Karwowski, Maria Morel-Espinosa, Jon Rees, Connie Sosnoff, Elizabeth Cowan, Michael Gardner, Lanqing Wang, Liza Valentin-Blasini, Lalith Silva, Víctor R. De Jesús, Zsuzsanna Kuklenyik, Cliff Watson, Tiffany Seyler, Baoyun Xia, David Chambers, Peter Briss, Brian A. King, Lisa Delaney, Christopher M. Jones, Grant T. Baldwin, John R. Barr, Jerry Thomas, James L. Pirkle, Christina Brosius, Kevin Caron, Carolina Fernandez, Cory Holder, Rudy Johnson, Cody Newman, Chris Reese, Denise Tevis, Dana Meaney Delman, Kara Polen, Anita Patel, Bobby N. Brewer, Macarena Garcia, Ian Williams, Kevin Chatham-Stephens, Jennifer Freed, Donald Hayes, Matt Ritchey
Journal: MMWR Morbidity and Mortality Weekly Report (2020)
Immunotherapy
Authors: M. Fujita, G. Kohanbash, H. A. McDonald, L. Delamarre, S. A. Decker, J. R. Ohlfest, H. Okada, H. Okada, P. Kalinski, R. Ueda, A. Hoji, G. Kohanbash, T. E. Donegan, A. H. Mintz, J. A. Engh, D. L. Bartlett, C. K. Brown, H. Zeh, M. P. Holtzman, T. A. Reinhart, T. L. Whiteside, L. H. Butterfield, R. L. Hamilton, D. M. Potter, I. F. Pollack, A. M. Salazar, F. S. Lieberman, M. R. Olin, B. M. Andersen, P. T. Grogan, M. Hunt, F. E. Popescu, Z. L. Xiong, C. Seiler, C. L. Forster, K. S. SantaCruz, W. Chen, B. R. Blazar, J. R. Ohlfest, J. Hu, C. J. Wheeler, S. Phuphanich, J. Rudnick, M. Nuno, N. Serrano, J. Dantis, J. Richardson, M. Mazer, H. Q. Wang, R. Chu, K. L. Black, J. Yu, Y. M. Li, D. A. Vallera, W. A. Hall, J. D. Rudnick, C. J. Wheeler, S. Phuphanich, R. M. Chu, M. Mazer, H. Wang, N. Serrano, M. Nuno, J. Richardson, J. Hu, K. L. Black, J. S. Yu, I. Yang, S. Han, T. Tihan, M. Wrensch, A. T. Parsa, Y. M. Li, D. A. Vallera, W. A. Hall, B. M. Andersen, M. A. Hunt, J. L. Gallardo, C. Seiler, G. E. Pluhar, J. R. Ohlfest, C. E. Brown, R. Starr, C. Martinez, J. Bading, J. A. Ressler, B. Badie, M. C. Jensen, R. P. Glick, A. Ksendzovsky, R. Zengou, P. Polak, V. Simonini, T. Lichtor, D. Feinstein, K. K. Chow, N. Ahmed, V. S. Salsman, Y. Kew, S. Powell, R. Grossman, H. E. Heslop, S. Gottschalk, F. H. Barnett, V. Marchetti, M. Wang, A. Johnson, L. Scheppke, R. Jacobson, G. Nemerow, M. Friedlander, N. Ahmed, V. Salsman, Y. Kew, A. M. Leen, C. M. Bollard, S. Powell, R. Grossman, C. Rooney, H. E. Heslop, S. Gottschalk, P. Z. New, C. M. Bollard, B. Salvoldo, H. Heslop
Journal: Neuro-Oncology (2010)
European Perspectives
Journal: Circulation (2009)

Liège, is best known for his pioneering studies on the role of dobutamine echocardiography for detecting myocardial ischaemia and viability.In addition, he established the importance of exercise echocardiography in ischaemic mitral regurgitation and asymptomatic aortic stenosis.Born in the south of Belgium to 2 secondary school teachers, Piérard enrolled as a medical student at the University of Liège at the age of 16.After graduation in 1975, he underwent a 5-year training period in internal medicine and cardiology and then moved to the renowned Thoraxcentre in Rotterdam, the Netherlands,
Highlights
Journal: JAMA (2015)

Use and Outcomes of Intracytoplasmic Sperm Injection 255Intracytoplasmic sperm injection (ICSI) is increasingly used in assisted reproduction involving patients without severe male factor infertility and without evidence of benefit compared with conventional in vitro fertilization (IVF).Boulet and colleagues assessed US trends in ICSI use in an analysis of 1996-2012 registry data from nearly 1.4 million fresh IVF cycles.The authors found that ICSI use doubled between 1996 and 2012, with the largest relative increase in cycles without a diagnosis of male factor infertility, and ICSI was not associated with improved reproductive outcomes, irrespective of a diagnosis of male factor infertility.
Leads from the MMWR. Yellow fever vaccine
Journal: JAMA (1984)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Burkitt's Lymphoma
Authors: Denis Burkitt
Journal: JAMA (1972)

<h3>Identification</h3> This tumor was first identified as a clinical syndrome early in 1957. The recognition that a number of tumors appearing in different but characteristic sites tended to occur together in the same individual, suggested that these might all be but different manifestations of a single tumor. Characteristic sites included the jaw, eyes, ovaries, kidneys, adrenals, salivary glands, thyroid, and testes. This clinical impression of a unitary process was subsequently strengthened by the observation that the age distribution among patients with the different tumors was similar and the geographical distribution identical. Subsequently, the histological and cytological features of the tumors were also shown to be identical. <h3>Previous Treatment</h3> These tumors were formerly diagnosed according to the organ or structure involved, eg, eyes: retinoblastoma; ovary: granulosa-cell tumor; adrenal: neuroblastoma; jaw: sarcoma, and were usually treated surgically. There was no follow-up, and there were no known survivors. <h3>First Treatment With Chemotherapy</h3> The
Study of DNA Methylation by Tobacco-Specific N-Nitrosamines
Authors: Andre Castonguay, Peter G. Foiles, Neil Trushin, Stephen S. Hecht
Journal: Environmental Health Perspectives (1985)

An enzyme-linked immunosorbent assay (BA-ELISA) involving use of biotin-labeled anti-rabbit IgG and avidin-labeled horseradish peroxidase was developed for the measurement of O6-methyl-2'-deoxyguanosine (O6-MedGuo). Up to 5 micrograms of methylated DNA was enzymatically hydrolyzed, and the extent of inhibition of binding of immobilized O6-MedGuo-bovine serum albumin to rabbit anti-O6-MedGuo was measured. Fifty percent inhibition of antigen-antibody binding was achieved with 2.5 pmole of of O6-MedGuo. Separation of O6-MedGuo from unmodified nucleosides by high-performance liquid chromatography (HPLC-BA-ELISA) allowed detection of 700 fmole O6-MedGuo in 1 mg of DNA. Among the tobacco-related carcinogens, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is one of the most potent. In F344 rats it induces nasal cavity, lung and liver tumors. Four hours after a single IV injection of NNK to F344 rats (87 mg/kg body weight), O6-MedGuo was present in target organs (mumole O6-MedGuo/mole dGuo) (nasal mucosa, 219; lung, 13.2; and liver, 34.5) but was not detectable in nontarget organs. F344 rats receiving daily IP injections of NNK (40 mg/kg body weight) for 14 days were sacrificed 24 hr after the last injection. The levels of (O6-Medguo/dGuo) were 7.9 and 11.4 mumole/mole in the nasal mucosa and lung, respectively. In the liver no O6-MedGuo was detected, but 1050 mumole of 7-MeGua/mole Gua was measured by HPLC-fluorimetry. No DNA methylation was observed in the nasal mucosa or liver of F344 rats treated with the nicotine-derived carcinogen N'-nitrosonornicotine.(ABSTRACT TRUNCATED AT 250 WORDS)
Reply
Authors: Steven R. Kohn, Maritza I. Perez
Journal: Journal of the American Academy of Dermatology (1994)

jected cases.In histamine-injected skin, CFA was increased in all patients tested.ELT values in patients with SS did not show any statistical difference from controls.A significant increase of vWF:Ag (but not of factor VIII [FVIII:C]) was observed in all patients with SS.The vWF:Ag!FVIII:C ratio did not show any difference between patients and normal controls.Likewise, .B-thromboglobulin did not show any statistical differences with the control group.Values of PAR, AT III, and serum plasminogen levels (increased!) showed significant differences when compared with those of control subjects.There was no correlation between the laboratory variables (vWF:Ag, FVIII:C, PAR, ELT, AT III, .B-thromboglobulin, plasminogen) and patient age, disease duration, digital ulcers, or number of organ systems involved.No appreciable statistical correlation among laboratory variables was found.Our findings suggest that there may be two distinct patterns of microvessel injury in SS: arteriolar damage and venular damage.In fact, in the skin tPA is usually stored in and released by the venular endothelial cells.Therefore deficient plasma levels of tPA and!or PFA would merely reflect a venular endothelial impairment in SS.On the basis of our and other authors' reports, this latter phenomenon, in contrast, does not actually occur.These findings are in agreement with the hypothesis of a predominant arteriolar microvessel injury and consequent release of endothelial-related proteins from relatively hypoxic venular endotheliocytes in patients with SS.Thus the PAR seems to indicate the presence of reversible platelet aggregates in patients with SS without abnormal release of the content of o-granules (insignificant increase of J3-thromboglobulin).Our data suggest that the venules in patients with SS are regularly able to release tissue-type activator. 4Indeed, histamine injection demonstrates that the venular endothelium maintains further fibrinolytic potential.The investigation of CFA and PFA could help clinicians test the residual endothelial pool of P A and monitor endothelial injury, but it should not be assumed that there is deficient release of tPA in patients with SS and Raynaud's phenomenon.Thus we suggest that treatment of SS with fibrinolysis-enhancing drugs?should be limited to those uncommon patients who show exhaustion of plasma and!or cutaneous fibrinolytic activity.
Neonatal Hypoglycemia
Authors: Boris Senior
Journal: New England Journal of Medicine (1973)

CLAMPING the cord abruptly changes the fuel economy in the newborn from total dependence on the mother to total dependence on self. For survival of the newborn, the flow of fuel must be maintained virtually without interruption during this critical phase of transition to independent existence. In the vast majority of infants, this continuation of flow is accomplished. The infant is not unprepared. Fuel is conserved and stored during intrauterine life and promptly mobilized after delivery. Nevertheless, the very complexity of these processes renders them susceptible to a variety of adverse influences and therefore also renders the newborn prone to . . .
Critique and Cavil
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Record of the Class of '98, Keokuk Medical College.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal