tbuckley/cabot-search huggingface dataset:
Effect of chronic ethanol feeding on lipid peroxidation and protein oxidation in relation to liver pathology
Authors: H Rouach
Journal: Hepatology (1997)

Liver lipid peroxidation, nonheme iron, antioxidants, and protein oxidation were investigated in experimental alcohol-induced liver disease in the rat. Wistar male rats were intragastrically and continuously infused for 4 weeks with a high-fat diet plus an ethanol or an isocaloric amount of dextrose, maintaining a high blood alcohol level (200-300 mg%). This model induced fatty liver, spotty necrosis, and focal inflammation. This pathology was associated with an enhanced lipid peroxidation and a decrease in the major antioxidant factors. Hepatic alpha-tocopherol and glutathione concentrations were significantly decreased in ethanol-fed rats. Glutathione peroxidase (GPx) was also decreased, whereas glutathione S-transferase (GST) was unaffected. The nonheme iron level was significantly decreased. Protein oxidation was assessed through three parameters: protein thiols, protein carbonyl groups, and the activity of glutamine synthetase (GS), a centrilobular enzyme particularly susceptible to free-radical- mediated damage. Ethanol-fed rats had decreased protein thiol concentrations and reduced GS activity, together with increased protein carbonyls. A significant correlation between GS activity and the pathological score was observed. This study confirms the ethanol-related increase in lipid peroxidation and shows that ethanol impairs the hepatic antioxidant potential. Furthermore, evidence of oxidative protein damage is given, including decreased activity of a key enzyme of ammonia metabolism. These protein disturbances may contribute to the pathogenesis of the observed liver damage.
Renovascular Hypertension
Authors: Irvine H. Page
Journal: JAMA (1982)

Renovascular hypertension was among the first models of hypertension to receive true scientific expression, but it has taken 50 years to arrive at some consensus as to how to treat it. Breslin, Swinton, Libertino, and Zinman have edited a book aimed at guiding the clinician. Their contributors have been well chosen. The coverage includes pathophysiology, natural history, radiology, renal angioplasty, and surgical treatment of renovascular hypertension. It is good that the interrelatedness of the varied regulatory mechanisms controlling blood pressure and tissue perfusion comes through, although not formally stated. Thus, too much dependence in diagnosis is not placed on any single datum, such as plasma renin activity. What needs constant emphasis is that the main reason for angioplasty, or surgical correction, is maintenance of renal function. Modern treatment of hypertension, renovascular or otherwise, can be very effective. Patients resistant to some form of treatment are rare indeed, if such exist.
Erratum: Prenatal and Childhood Traffic-Related Pollution Exposure and Childhood Cognition in the Project Viva Cohort (Massachusetts, USA)
Authors: Maria H. Harris, Diane R. Gold, Sheryl L. Rifas-Shiman, Steven J. Melly, Antonella Zanobetti, Brent A. Coull, Joel D. Schwartz, Alexandros Gryparis, Itai Kloog, Petros Koutrakis, David C. Bellinger, Roberta F. White, Sharon K. Sagiv, Emily Oken
Journal: Environmental Health Perspectives (2019)
BOOK REVIEWS
Authors: DAVID M. GOLDENBERG
Journal: JNCI Journal of the National Cancer Institute (1992)

Journal Article BOOK REVIEWS Get access Immunoscintigraphy: Practical Aspects and Clinical Applications A. C. Perkins , M. V. Pimm . New York : John Wiley & Sons , 1991 . 208 pp. $ 59.95. DAVID M. GOLDENBERG DAVID M. GOLDENBERG Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 84, Issue 1, 1 January 1992, Pages 53–54, https://doi.org/10.1093/jnci/84.1.53-a Published: 01 January 1992
Staphylococcal food poisoning in the United States. New facts and old misconceptions
Authors: S. D. Holmberg
Journal: JAMA (1984)

To determine the current epidemiologic characteristics of staphylococcal food-borne disease (SFD), we reviewed 131 outbreaks reported to the Centers for Disease Control, Atlanta, from 1977 through 1981. Staphylococcal food-borne disease was the second most common cause of reported food-borne illness, affecting more than 7,000 persons during the five-year period; 10% of these patients visited or were admitted to hospitals for their illnesses. The proportion of outbreaks attributable to<i>Staphylococcus aureus</i>enterotoxins A through E has changed, with enterotoxin A being the only toxin incriminated during the last three years of this review. Milk—the most common source of enterotoxin C- and D-producing strains—and commercially packed foods are less common causes of SFD outbreaks now than they were before 1960. However, previously cooked, proteinaceous foods remain preeminent in causing SFD. The presence or absence of fever in infected persons, skin lesions in food handlers, or large numbers of staphylococci in food were unreliable as diagnostic criteria. Thorough epidemiologic investigation remains crucial to identifying SFD and its sources. (<i>JAMA</i>1984;251:487-489)
Dissociation of serum bilirubin and alkaline phosphatase in infectious mononucleosis
Authors: F. Shuster
Journal: JAMA (1969)

Liver function tests were performed on 46 patients with infectious mononucleosis. Abnormal values were found in 38 (83%). Thirty (65%) had dissociation between serum bilirubin concentration and alkaline phosphatase activity. Occasionally serum alkaline phosphatase activity rose to unusually high levels, even with normal bilirubin concentration. These findings may be helpful in diagnosis and differential diagnosis of infectious mononucleosis.
Book Review Textbook of Surgery: The biological basis of modern surgical practice Fourteenth edition. Edited by David C. Sabiston, Jr. 2208 pp., illustrated. Philadelphia, W.B. Saunders, 1991. $75. ISBN 0–7216–3492–3 . Sabiston Review of Surgery By David C. Sabiston, Jr. 291 pp. Philadelphia, W.B. Saunders, 1992. $29.95. ISBN 0–7216–3534–2 . Textbook of Surgery: Pocket companion Edited by David C. Sabiston, Jr., and H. Kim Lyerly. 1044 pp. Philadelphia, W.B. Saunders, 1992. $18.95. ISBN 0–7216–…
Authors: Charles J. McCabe
Journal: New England Journal of Medicine (1992)
Interactions of Chrysotile Asbestos with Erythrocyte Membranes
Authors: Arnold R. Brody, Lila H. Hill
Journal: Environmental Health Perspectives (1983)

Chrysotile asbestos causes lysis of red blood cells. It has been proposed that the mechanism of hemolysis is mediated through interactions between asbestos and cell membrane glycoproteins. Our studies support this concept and the following results are reported. Electron microscopy shows that asbestos fibers distort red blood cells and bind to cell membranes which may become wrapped around the fibers. This reaction is prevented by pretreatment of the cells with neuraminidase. The distribution of lectins which bind to membrane glycoproteins is altered by treating the cells with asbestos. Cell distortion and membrane deformation consequent to asbestos treatment correlate with a clear increase in the ratio of intracellular Na+:K+ ions.
Pain
Authors: Charles B. Wilson
Journal: JAMA (1967)

Reflecting careful planning, an imposing list of contributors immediately prepares the reader for an authoritative and fresh look at a multifaceted subject, pain. Few symposia have produced as much information. Forty-one papers are grouped by subject into six sections. The opening section deals with anatomical substrata for pain perception. Among other papers, an anatomico-clinical study of 74 cordotomies by Nathan and Smith will particularly interest surgeons. Contributors to the next section, parameters of pain and analgesia, consider narcotic and non-narcotic analgesics—their site and mode of action, their assay in animals and in man, their use in the control of pain, and determination of drug dependence and dependence liability. A separate section concerns operative techniques for the relief of pain arising in the body. Noordenbos ascribes recurrence of pain after cordotomy to a multisynaptic afferent system for pain conduction. Advocates of thoracic, high cervical, and percutaneous cordotomy discuss each procedure and
Physiology and Pathology of the Semicircular Canals.
Journal: JAMA (1910)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ITALY
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The International Medical Annual and Practitioners' Index.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Cause of Cancer
Journal: JAMA (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Inaugural Address
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
General Surgery
Authors: R. Dale Liechty
Journal: JAMA (1980)

With the current emphasis on updated information, this loose-leaf book revives an important concept: each year the subscriber receives revised material. He snaps open the five-ring binder, discards the old pages, and locks in the new. Medical books no longer have to stagnate for four or more years. Indeed, the authors might include information they gather at meetings, and, theoretically, this new material could reach the subscriber about the same time it appears in a journal—all of this because of new computer-assisted printing technology. Almost any number of changes in the text or in the references can be made while leaving the body of the book intact. For example, I received 14 basic chapters (448 pages) along with five revised chapters. Dr Block updates his excellent chapter on endocrinology by inserting transphenoidal microdissection of pituitary adenomas (to replace heavy particle irradiation) as the preferred treatment for Cushing's disease. Similarly, Dr
Care of the patient with advanced cancer
Authors: C. G. Moertel
Journal: JAMA (1980)

During 1980 cancer will afflict more than 700,000 Americans, and some 400,000 Americans will die of cancer. As a cause of death, cancer is second only to heart disease. Certainly from the standpoint of emotional impact of disease it is second to none. As such, cancer presents a major challenge to the practicing physician in every area of medicine from surgery, therapeutic radiology, and medical oncology to dermatology, psychiatry, and family practice. Although the pages of this and other medical journals, the programs of postgraduate courses, and the curricula of our medical schools often present measures for early diagnosis of cancer, as well as advances in treatment with surgery, radiation, and chemotherapy, it must regrettably be admitted that these measures will be successful in terms of cure for only 4096 of cancer patients. The majority of patients with malignant disease will suffer the effects of advanced cancer and will present
The effect of head elevation on cerebral perfusion pressure in fulminant hepatic failure , Depts. of Medicine, Neurosurgery and Neurology, Jefferson Medical College, Philadelphia, PA
Journal: Hepatology (1995)

The inhibitor titer is the most important clinical measurement in inhibitor patients, and the Nijmegen method is preferable to the original and well-established Bethesda assay for this purpose; however, both methods have high inter-laboratory variability. Monitoring inhibitor patients after treatment with bypassing agents is difficult. Treatment with recombinant activated factor VII (rFVIIa; NovoSeven®, Novo Nordisk, Bagsværd, Denmark) can be monitored with assays for FVII clotting activity or with a specific assay for FVIIa; while the latter is more reproducible, its relevance to the clinical response of individual patients remains unclear. Recent years have also witnessed a revival of global assays, which contribute useful additional information and which may be more relevant to the hemostatic state of individual inhibitor patients. One such assay currently undergoing a renaissance is the thrombin generation test (TGT). The TGT has many methodological variations—several of which have been studied in our laboratory—and shows the most promise for use in treatment monitoring. This article reviews the assays most appropriate for monitoring inhibitor patients and discusses some of the most recent developments in the use of global assays in this indication.
Digital tools for mental health in a crisis
Authors: None The Lancet Digital Health
Journal: The Lancet Digital Health (2021)

In January, 2021, WHO member states stressed the importance of integrating mental health into response and preparedness plans for public health emergencies, such as the current COVID-19 pandemic. To meet these aims, the WHO Executive Board urged member states to develop and strengthen services for mental health and psychosocial support (MHPSS) by promoting equitable access to remote health services during the pandemic and beyond, and to study the impact of the pandemic on mental health. What has been the role of digital tools for mental health during the pandemic thus far, and how might it help health services identify challenges that are still to come?
General urology
Authors: Duncan E. Govan
Journal: JAMA (1963)

Dr. Donald Smith, chairman of the Department of Urology at the University of California School of Medicine in San Francisco, has released the fourth edition of his book<i>General Urology</i>. The preface indicates that it originally was written for the medical student and for the medical practitioner. This new edition retaining the original format is again a very didactic book containing positive statements designed to give the student as many concrete facts as possible in the shortest period of time. This method of approach has great advantages for the medical student and practitioner. Dr. Smith stresses the importance of a clinical history and physical examination and indicates in great detail the special examinations common to the urologist. In general, the author's remarks concerning investigative principles are superb and well portrayed. However, many will take exception to Dr. Smith's thoughts on the significance of the urine culture. The chapter on hydroflux,
Anti-retroviral treatment regimens and immune parameters in the prevention of systemic HIV-related non-Hodgkin's lymphoma
Authors: M. Bower, J. Stebbing, C. Thirlwell, T. Newsom-Davis, A. Waterston, S. Mandalia, B. Gazzard
Journal: Journal of Clinical Oncology (2004)

1034 Background: Immunosuppression induced by the human immunodeficiency virus (HIV) leads to an increased risk of non Hodgkin's lymphoma (NHL). We measured the influence of immunological factors and highly active antiretroviral therapy (HAART) regimes on this risk. As there are few data demonstrating that non nucleoside reverse transcriptase inhibitors (NNRTI) can protect from AIDS-defining illnesses, we compared different HAART regimens. Methods: The protective effect of HAART regimens, containing protease inhibitors (PI) and/or NNRTIs on the development of NHL was examined in a prospectively recorded cohort of 9,621 HIV-infected individuals. Lymphocyte and natural killer subset data were also examined and entered in a univariate and multivariate analysis to establish risk of NHL. Results: 280 patients have been diagnosed with lymphoma including 206 with systemic NHL, 55 with primary cerebral lymphoma and 19 with Hodgkin's disease. During the HAART era (1996–2003), 5,832 individuals have been identified as being at risk of systemic NHL, representing a total of 34,133 patient years of follow up. Of these, 102 patients have been diagnosed with systemic HIV-related NHL. Univariate analysis demonstrated that increased age, higher nadir CD4 and CD8 T cell counts, CD19 B cell count, CD16/56 natural killer count and exposure to NNRTI or PI containing HAART conferred significant protection against NHL (p<0.05). In a multivariate analysis, age, nadir CD4 and CD8 T cell counts and exposure to HAART were independent predictors of risk of NHL (p < 0.02). NNRTI based HAART (adjusted rate ratio 0.4, 95% CI 0.3 to 0.5) had an identical protective effect to PI-based HAART and these were significantly more protective than nucleoside analogues alone (rate ratio 0.5, 95% CI 0.4 to 0.7) or no anti-retrovirals (p<0.001). Conclusions: HAART induced maintenance of CD4 and CD8 counts protects from systemic AIDS-related NHL. No significant financial relationships to disclose.
Specialty Abstracts
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal