tbuckley/cabot-search huggingface dataset:
The Diary of a Resurrectionist 1811-1812 to which are added an account of the resurrection men in London, and a short history of the passing of the Anatomy Act.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Error in Byline
Journal: JAMA Pediatrics (2019)

Yoram Unguru, MD, MS, MA; Melanie Brooke Bernhardt, PharmD, MS; Stacey L. Berg, MD; Liza-Marie Johnson, MD, MPH, MSB; Kimberly Pyke-Grimm, PhD, RN, CNS; Catherine Woodman, MD; Conrad V. Fernandez, MD
MORE ON PURE-FOOD LEGISLATION.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hospital readmissions among survivors six months after myocardial revascularization
Authors: B. A. Stanton
Journal: JAMA (1985)

One neglected but important measure of early morbidity after coronary artery bypass graft (CABG) operations is rehospitalization. As part of a prospective study of recovery after elective CABG procedures conducted at four academic medical centers, data from all readmissions occurring within the first six postoperative months were collected for 326 patients. A total of 24% of patients had readmissions. The most common categories of readmission discharge diagnoses were cardiac (57%), noncardiac (26%), and surgical sequelae (17%). Factors from the initial hospitalization identified as risk factors for rehospitalization included: length of stay in intensive care unit after surgery, severe noncardiac complications, duration of preoperative cardiac symptoms, intra-aortic balloon insertion, and preoperative resting angina. These findings help to identify a subset of at risk patients for whom more careful surveillance might be beneficial. (<i>JAMA</i>1985;253:3568-3573)
Proposed Law Governing Medical Corps Promotions.
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medical Parasitology
Authors: Yezid Gutierrez
Journal: JAMA (1987)

This is the sixth edition of this book, now well known by medical students and physicians, who use it regularly. It contains 17 chapters filling 371 pages. The first two chapters deal with generalities about parasites and their relations with their hosts, the last seven with techniques, symptoms and signs, diagnosis, serological tests, etc. The bulk of the text, eight chapters (289 pages), deals with the parasites of human importance, divided loosely into groups either by organ system (eg, lumen-dwelling protozoa) or phylogenetically (eg, the cestodes). The book is well illustrated with photographs in both black and white and color, ranging from classic clinical examples to scanning electron microscopy of some parasites. There are diagrams and tables well chosen from known articles in the literature. The arrangement of the book by organ, tissue, or group of parasite appears at first somewhat erratic, and in some instances the relationships of the
Modified skin lesions during concurrent varicella and measles infections
Authors: T. C. Merigan
Journal: JAMA (1968)

Seven patients with measles and chickenpox concurrently were observed. In five children evidence of viral interference was present, which resulted in a clearly discernible modification of one or the other exanthem. A phenomenon not previously described was observed in three patients; the number of varicella lesions were markedly diminished when the measles appeared concomitantly with the chickenpox. In a fourth similar patient there appeared to be later breakthrough of varicella lesions. In a single patient the chickenpox lesions appeared before those of the measles, and local sparing of skin by the rubeola rash about the varicella lesions was noted.
Sexual activity and vaginal colonization with genital mycoplasmas
Authors: W. M. McCormack
Journal: JAMA (1972)

The relationship of sexual activity to vaginal colonization with the genital mycoplasmas (T-strain mycoplasmas and<i>Mycoplasma</i>hominis) was studied in 183 student and graduate nurses. Participants with no history of sexual contact were virtually free of mycoplasmas, whereas 37.5% of those with a history of intercourse with a single partner and 75.0% of those who had had intercourse with three or more partners were colonized with T-mycoplasmas. These data suggest that T-mycoplasmas are acquired through sexual contact and are part of the vaginal flora of healthy sexually active young women.
The Metabolic N-Oxidation of Carcinogenic Arylamines in Relation to Nitrogen Charge Density and Oxidation Potential
Authors: Fred F. Kadlubar, Peter P. Fu, Hyewook Jung, Ali U. Shaikh, Frederick A. Beland
Journal: Environmental Health Perspectives (1990)

The N-oxidation of carcinogenic arylamines to form N-hydroxy arylamines has long been regarded as a necessary metabolic step for conversion to proximate carcinogenic derivatives. In contrast, arylamine ring-oxidation has been generally considered to be an important detoxification mechanism. Both enzymatic reactions are carried out in the liver and usually involve the cytochrome P-450 monooxygenases. Studies on the metabolic oxidation of certain arylamines have indicated that the relative charge density on nitrogen versus ring-carbon atoms for a nitrenium/carbenium ion-enzyme intermediate correlates with the relative proportion of N-versus ring-hydroxylated products that are formed. A further examination of this approach now shows that positive charge density on the nitrogen, as estimated by Hückel molecular orbital calculations, is consistent with the formation of N-hydroxy arylamines from aniline, 4-aminoazobenzene, 2-naphthylamine, 4-aminobiphenyl, 2-aminofluorene, and 6-aminochrysene, but not from 1-naphthylamine, 1-aminopyrene, 6-aminobenzo[a]pyrene, or 7-aminobenz[a]anthracene. Since greater positive charge on the arylamine nitrogen implies a greater charge localization during the transition state of the enzyme-substrate complex, we envisioned that higher oxidation potentials for arylamines, which might be expected to correlate inversely with the ease of total oxidation, would instead be predictive of the relative extent of N-oxidation.(ABSTRACT TRUNCATED AT 250 WORDS)
Microsurgical treatment of transient cerebral ischemia. Preliminary results in 50 patients
Authors: D. S. Samson
Journal: JAMA (1979)

Extracranial-intracranial arterial bypass is a microneurosurgical procedure recently introduced in the treatment of a variety of cerebrovascular ischemic states. Fifty patients with transient ischemic attacks (TIAs) localized to the distribution of the internal carotid artery underwent this procedure during a 48-month period. All have been followed up for at least 14 months after surgery. There were no operative deaths, and notable postoperative morbidity has been experienced in less than 8% of cases. Seventy-six percent of patients have been asymptomatic since surgery, 14% have continued to experience TIAs, and 6% have had completed strokes (2% occurring in the operative hemisphere). (<i>JAMA</i>241:376-378, 1979)
Abstract 2318: Selective Mitochondrial Translocation of Phosphorylated PKCε in Viable Myocytes Overexpressing Urocortin after Cardioplegic Arrest and Reperfusion: Physical Interaction of Phosphorylated PKCε with the Kir6.1 Cardiac Potassium Channel Subunit as a Potential Mechanism of Cardioprotection
Authors: Carol Chen-Scarabelli, Giuseppe Faggian, Maddalena Tessari, Zhaokan Yuan, Justin Di Rezze, Louis Saravolatz, Alessandro Mazzucco, Tiziano M Scarabelli
Journal: Circulation (2008)

Cardioplegic arrest and subsequent reperfusion inevitably expose the heart to an iatrogenic ischemia/reperfusion injury (iIRI). We previously reported that iIRI caused myocyte induction of urocortin, an endogenous cardioprotective peptide. This study investigates in patients undergoing cardiac surgery the cardioprotective role and the mechanism of action of Ucn, with respect to PKCε expression, activation and relocation. Two sequential biopsies were obtained from the right atrium of 25 patients undergoing coronary artery bypass grafting at the start of grafting (internal control) and 10 minutes after release of the aortic clamp. In hearts exposed to iIRI, induction of Ucn was documented both at the mRNA (255% of basic levels; p &lt; 0.05) and protein level (four-fold increase; p &lt; 0.01). iIRI also induced a selective increase of PKC-ε mRNA (225% of internal control; p &lt; 0.05) and a two-fold overexpression of total PKCε (p &lt; 0.05), which paralleled a 2.9-fold increase in PKCε phosphorylation (p &lt; 0.01). Mitochondrial translocation of activated PKCε was only observed in post-cardioplegic samples, using both subcellular fractionation (p &lt; 0.05) and immunostaining techniques (p &lt; 0.05). Importantly, enhanced PKCε/mitochondria colocalization was selectively observed in viable myocytes, showing concurrently positive staining for urocortin (p &lt; 0.05). Finally, co-immunoprecipitation experiments documented an iIRI-enhanced physical interaction of phosphorylated PKCε with the Kir6.1 subunit of the K ATP channels (p &lt; 0.05). Following iIRI, urocortin expression in viable cells selectively colocalized with enhanced phosphorylation and mitochondrial relocation of PKCε, suggesting a cardioprotective role for endogenous Ucn. The physical interaction of activated PKCε with Kir6.1, enhanced by cardioplegic arrest, may represent a conjectural mechanism of urocortin-mediated cardioprotection.
Abstract 3311: Relationships Among Renal Function Loss Within the Normal to Mildly Impaired Range, Arterial Stiffness, Inflammation and Oxidative Stress
Authors: masanobu yoshida, Hirofumi Tomiyama, Chisa Matsumoto, Jiko Yamada, Kazuki Shiina, Akira Yamashina
Journal: Circulation (2007)

Objective: This study was conducted to clarify whether subjects with mildly impaired renal function {glomerular filtration rate (GFR) = 60 – 89 mL/min per 1.73 m 2 body surface area} show increased arterial stiffness, microinflammation and oxidative stress as compared to those with normal renal function, and also to examine the association of these parameters with GFR loss in middle-aged Japanese men with a low cardiovascular risk. Methods and Results: The brachial-ankle pulse wave velocity (baPWV) and plasma levels of C-reactive protein (CRP) and lipid peroxides (LipOX) were measured in 1873 male subjects (42±9 years old). The baPWV, but not the CRP or LipOX, was increased in subjects with mildly impaired renal function (Figure ). Multiple linear regression analysis demonstrated a significant relationship between the GFR and the baPWV independent of the conventional atherosclerotic risk factors (beta = −0.08, t-value = −2.19, p&lt;0.05). This relationship was significant even in subjects with renal function within the normal range. Conclusions : Increased arterial stiffness, rather than microinflammation and/ or oxidative stress, may underlie the elevated cardiovascular risk in subjects with mildly impaired renal function. The association between GFR loss and arterial stiffness seems to precede the occurrence of microinflammation and/or oxidative stress associated with GFR loss.
Abstract 158: Mutantp53, MAPK and STAT3 promote metastasis to the brain: Demonstrated by protein, gene, and functional analysis
Authors: John V. Wainwright, Jared B. Cooper, Anisha Chandy, Chirag D. Gandhi, Meic H. Schmidt, Meena Jhanwar-Uniyal
Journal: Cancer Research (2019)

Abstract Metastatic tumors to the brain arise from a specific subset of neoplastic cells originating from primary tumors such as lung, breast, colon, etc which disseminate specifically to the cerebral gray/white matter junction. Genetic and epigenetic mechanisms of this complex metastatic transformation are yet to be defined. Inactivation of the tumor suppressor gene p53 is one of the most frequent genetic alterations seen in human cancers. Further, extracellular regulated kinase (ERK), a component of mitogen activated protein kinase (MAPK) and Signal transducer and activator of transcription 3 (STAT3) plays a crucial role in differentiation, proliferation and migration, and is aberrant in many tumors. We hypothesize that aberrant p53, ERK1/2 and STAT3 contribute to metastatic brain tumors. Results demonstrated that: 1. Immunohistochemical analysis (IHC) of mutant p53 (mt-p53), phosphorylated-ERK1/2 Thr202/Tyr204 (pERK 1/2) and phosphorylated-STAT3Tyr705 revealed that 66% of metastatic brain tumors expressed mt-p53, 86% of tumors expressed pERK 1/2, and 75% nuclear expression of pSTAT3Tyr705; 2. Gene expression profiling showed that 17, 44 and 21 differentially expressed genes in metastatic tumors were p53, MAPK and STAT3 associated, respectively with alterations in genes associated with cell cycle regulation, neurogenesis, and differentiation and reprogramming and metastases; and 3. Metastatic breast cancer cells grown in astrocytic media displayed increased cell proliferation and enhanced S-phase cell cycle entry. Migration of primary tumor cells was significantly enhanced in astrocytic media as well. Inhibitors of MAPK (U0126) and STAT3 (STAT3 inhibitor SVI-201) suppressed cell proliferation and migration. Metastatic tumor cells and astrocytes were shown to grow amicably together, forming cell-to-cell interactions. These findings suggest that mt-p53 and aberrant MAPK and STAT3 play a crucial role in brain metastasis, and that the cerebral milieu provides a suitable microenvironment for metastatic cells to grow and disseminate and inhibition of aforementioned pathway can provide suitable therapeutic strategies. Citation Format: John V. Wainwright, Jared B. Cooper, Anisha Chandy, Chirag D. Gandhi, Meic H. Schmidt, Meena Jhanwar-Uniyal. Mutantp53, MAPK and STAT3 promote metastasis to the brain: Demonstrated by protein, gene, and functional analysis [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 158.
The Extra Pharmacopoeia of Martindale and Westcott.
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE PAN-AMERICAN MEDICAL CONGRESS.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
What about fellowships?
Authors: R. Tracy
Journal: JAMA (1978)

The annualMedical Education Numberof<i>JAMA</i>customarily makes only a passing reference to basic science fellowships and clinical fellowships in summarizing teaching responsibilities of faculties. Persons seeking clinical fellowships find that published data are almost nonexistent. No specific accrediting mechanism exists. Fellowships, subspecialty training, and residencies are not easily distinguishable by definition. A time-honored statement used by the Council on Medical Education of the American Medical Association was: A fellowship is a form of apprenticeship which in some cases is indistinguishable from a residency although it usually offers a greater opportunity for teaching, the study of basic sciences, and research. Ordinarily, a fellowship is a university rather than a hospital appointment. Fellowships vary in length, but they are usually of one or two years' duration. At one time, the Council on Medical Education evaluated graduate training programs under a listing of "Residencies and Fellowships," but in 1959 the term
Functional recovery and orthopedic management of brachial plexus palsies
Authors: M. M. Hoffer
Journal: JAMA (1981)

Functional recovery in 133 patients with brachial palsy is documented over a five-year period. Clinical examination is more reliable than electromyogram or myelogram for obtaining prognostic information. Erb's C V, VI palsies have improved function with cuff transfers and elbow flexor plasties. Posterior cord palsies often require extension plasties of the hand and glenohumeral fusions. C V, VI, VII palsies may require all of these procedures. Klumpke C VIII-T I palsies develop arm-trunk holding power. Adults with total palsies often complain of continued pain, which may be relieved by orthoses. (<i>JAMA</i>1981;246:2467-2470)
Congenital rubella syndrome: a continuing problem
Authors: W. A. Orenstein
Journal: JAMA (1982)

The 1964-1965 rubella pandemic resulted in approximately 20,000 malformed infants and 30,000 stillbirths in the United States, with an estimated economic impact of approximately $1.5 billion.<sup>1</sup>The opportunity to prevent similar tragedies was provided when rubella vaccine was licensed in 1969. Initial control efforts in the United States were aimed at preschool and young school-aged children to decrease the overall number of rubella cases and, consequently, the chances of exposing a susceptible pregnant female. Vaccination of susceptible postpubertal females was given lower priority. Implementation of this strategy has resulted in an interruption of the characteristic epidemics of rubella at six- to nine-year intervals, a marked reduction in the overall incidence of rubella, and prevention of epidemics of congenital rubella syndrome (CRS).<sup>2</sup>The major impact has been on young school-aged children, among whom rubella incidence decreased 89% between 1966-1968 and 1975-1977. Unfortunately, less progress has been made in controlling
Fever of unknown origin
Journal: BMJ (2006)

diabetes are improved by better control, largely based around the diabetes control and complications trial and the UK prospective diabetes study, 3 14 although the evidence base for desirable monitoring intervals is weaker, as these trials did not aim to examine periodicity of monitoring.The physiology of HbA 1c described above, however, forms a logical basis for avoiding very frequent testing, as no data assessing rate of change over short periods exist.The guidance makes little reference to situations in which HbA 1c measurement is known not to be valid. 15These are established from observational studies and follow from the physiology of HbA 1c .No evidence is available on the use of HbA 1c in these situations.Theoretically, if the factor influencing HbA 1c is stable, changes in the value over time might still reflect changes in diabetic control even if absolute values cannot be compared with target values.However, as situations of increased haemoglobin turnover are often not stable, if these values are interpreted at all this should logically be combined with home glucose measurement as an indicator of day to day control.We thank Susan Richardson for typing