tbuckley/cabot-search huggingface dataset:
Drugs for Postmenopausal Osteoporosis
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Carbohydrate restriction reverses NAFLD by altering hepatic mitochondrial fluxes in humans
Authors: Panu Luukkonen, Sylvie Dufour, Kun Lyu, Xian-Man Zhang, Antti Hakkarainen, Tiina E. Lehtimäki, Gary W. Cline, Kitt Falk Petersen, Gerald I. Shulman, Hannele Yki-Järvinen
Journal: Journal of Hepatology (2020)
Competition and the cost of hospital care, 1972 to 1982
Authors: J. C. Robinson
Journal: JAMA (1987)

Using 1982 data from 5732 US hospitals, we found that costs were substantially higher in hospitals operating in more competitive local environments than in hospitals in less competitive environments. After controlling for wage rates, patient case mix, state regulatory programs, and hospital teaching role, average costs per admission were found to be 26% higher in hospitals in the most competitive markets (more than ten hospitals within a 24-km radius) than in hospitals with no competitors within a 24-km radius. Average costs per patientday were 15% higher in the most competitive markets than in hospitals with no neighbors. These findings on the cost implications of nonprice competition among hospitals suggest that the new modes of hospital payment will have a greater disruptive impact on hospital behavior in areas with many, rather than few, hospitals. In anticipating the effects of new modes of payment on hospital behavior, policymakers should consider the nature of quality competition as well as price competition within local markets. (<i>JAMA</i>1987;257:3241-3245)
"Properties of the COPD assessment test in a cross-sectional European study." P.W. Jones, G. Brusselle, R.W. Dal Negro, M. Ferrer, P. Kardos, M.L. Levy, T. Perez, J.J. Soler Cataluna, T. van der Molen, L. Adamek and N. Banik. Eur Respir J 2011; 38: 29-35.
Journal: European Respiratory Journal (2011)
Book Review Voice Science Edited by Robert Thayer Sataloff. 291 pp., illustrated. San Diego, CA, Plural Publishing, 2005. $79.95. 1-59756-038-3 Clinical Assessment of Voice Edited by Robert Thayer Sataloff. 382 pp., illustrated. San Diego, CA, Plural Publishing, 2005. $79.95. 1-59756-039-1 Treatment of Voice Disorders Edited by Robert Thayer Sataloff. 435 pp., illustrated. San Diego, CA, Plural Publishing, 2005. $79.95. 1-59756-040-5
Authors: Paul W. Flint, Robin Samlan
Journal: New England Journal of Medicine (2006)
New Drugs and Developments in Therapeutics
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE EDUCATION OF THE INTERNE.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Straight arteriovenous shunt for long-term hemodialysis
Authors: A. Shimizu
Journal: JAMA (1971)

Over a 35-month period straight silicone rubber shunts for long-term hemodialysis have been used at St. Joseph's Hospital, Hamilton, Ontario in 30 patients. The average survival time of the arterial cannula varied with the time the patient had been in treatment with the long-term dialysis program: 24.5 months if the patient was admitted to the program in 1967, 14 months if he was admitted to the program in 1968, and 6.6 months if he was admitted to the program in 1969. The main advantage with this type of shunt was that declotting was readily achieved. The average venous-cannula survival time for the present cannula was six months.
TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1–TRAF2 complex to sensitize tumor cells to TNFα
Authors: James E. Vince, Diep Chau, Bernard Callus, W. Wei-Lynn Wong, Christine J. Hawkins, Pascal Schneider, Mark McKinlay, Christopher A. Benetatos, Stephen M. Condon, Srinivas K. Chunduru, George Yeoh, Robert Brink, David L. Vaux, John Silke
Journal: The Journal of Experimental Medicine (2008)
Editorial: Humidification of inspired air.
Journal: BMJ (1975)

the safety and efficacy of the 36 000 products which can be prescribed and which existed before it was set up.The Committee must surely have priorities in examination of established medicines, and it might be useful for it to review the antirheumatic drugs as one of those priorities.Anti- rheumatic drugs account for half the commonly reported iatrogenic deaths in Britain, and gold therapy produces the highest number of deaths per prescription.7So the question still remains in 1975, is gold therapy worth the risk ?
Carpals
Authors: Paula Tatarunis
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sodium Fluoride and Cell Growth
Authors: C. G. Learoyd
Journal: BMJ (1964)

injected to pregnant rats.No cardiovascular abnormalities were produced, but anoph- thalmia occurred in some of the test foetuses.In addition abnormalities of the central nervous system were produced.The net incidence of malformations in this series was similar to that occurring in my own.In view of the work of Robson and his co-workers,' who have demonstrated abnor- malities in the rodent placenta following the administration of 5H.T., it is tempting to suggest the possibility that microphthalmia and other abnormalities in the derivatives of the neural ectoderm in these animals could be related to anoxia.This possibility is supported by the findings of Brent and Franklin,4 who clamped the uterine vessels for up to three hours on the ninth day of gestation of the rat.On the twenty-first day the abnormalities observed were microphthalmia, renal aplasia and agenesis, anen- cephaly, and hydrocephalus.
Tamoxifen Flare
Authors: Daniel J. Arnold
Journal: JAMA (1979)

<h3>To the Editor.—</h3> The recent article "Tamoxifen Flare in Advanced Breast Cancer" by Plotkin et al (240:2644, 1978) emphasizes an often-ignored phenomenon. We have analyzed our experience with this agent in treating 68 postmenopausal patients with advanced breast cancer. The flare phenomenon was specifically sought in a prospective fashion. Six patients experienced a transient flare of bone or soft-tissue pain. One of these flares was accompanied by mild and transient hypercalcemia. Of these six patients, two attained objective response, and one showed a subjective improvement accompanied by a lessthan-50% reduction in measurable disease. Two patients had progressive disease while receiving tamoxifen citrate. Early in the study, tamoxifen therapy was discontinued in one patient because of flare, before there was any. possibility of evaluating her response. She subsequently failed to respond to therapy with doxorubicin hydrochloride (Adriamycin) or megestral acetate (Megace) before dying of progressive disease three months after the tamoxifen
Third European Conference on Clinical Oncology and Cancer Nursing
Journal: JNCI Journal of the National Cancer Institute (1984)

Journal Article Third European Conference on Clinical Oncology and Cancer Nursing Get access JNCI: Journal of the National Cancer Institute, Volume 72, Issue 6, June 1984, Page 1465, https://doi.org/10.1093/jnci/72.6.1465-d Published: 01 June 1984
The Thrombocytopenia of Wiskott Aldrich Syndrome Is Not Related to a Defect in Proplatelet Formation
Authors: Elie Haddad, Elisabeth Cramer, Christel Rivière, Philippe Rameau, Fawzia Louache, Josette Guichard, David L. Nelson, Alain Fischer, William Vainchenker, Najet Debili
Journal: Blood (1999)
<i>I Principi Fondamentali della Anthropologia Criminale. Guida per i Guidizi Medico-forensi nelle questioni di imputabilita.</i> Dei Dottore Guissepe Antonini. Manual Hoepli. (Milano: Ulrico Hoepli, 1906.)
Authors: W. R. D.
Journal: American Journal of Psychiatry (1906)
The Kinase IKKβ Regulates a STING-and NF-κB-Dependent Antiviral Response Pathway in Drosophila
Authors: A. Goto, K. Okado, N. Martins, H. Cai, V. Barbier, O. Lamiable, L. Troxler, E. Santiago, L. Kuhn, D. Paik, N. Silverman, A. Holleufer, R. Hartmann, J. Liu, T. Peng, A. Hoffmann J., C. Meignin, L. Daeffler, L. Imler J.
Journal: Immunity (2020)
Chemical Nature and Immunotoxicological Properties of Arachidonic Acid Degradation Products Formed by Exposure to Ozone
Authors: Michael C. Madden, Mitchell Friedman, Nancy Hanley, Elizabeth Siegler, Jacqueline Quay, Susanne Becker, Robert Devlin, Hillel S. Koren
Journal: Environmental Health Perspectives (1993)

Ozone (O3) exposure in vivo has been reported to degrade arachidonic acid (AA) in the lungs of rodents. The O3-degraded AA products may play a role in the responses to this toxicant. To study the chemical nature and biological activity of O3-exposed AA, we exposed AA in a cell-free, aqueous environment to air, 0.1 ppm O3, or 1.0 ppm O3 for 30-120 min. AA exposed to air was not degraded. All O3 exposures degraded > 98% of the AA to more polar products, which were predominantly aldehydic substances (as determined by reactivity with 2,4-dinitrophenylhydrazine and subsequent separation by HPLC) and hydrogen peroxide. The type and amount of aldehydic substances formed depended on the O3 concentration and exposure duration. A human bronchial epithelial cell line (BEAS-2B, S6 subclone) exposed in vitro to either 0.1 ppm or 1.0 ppm O3 for 1 hr produced AA-derived aldehydic substances, some of which eluted with similar retention times as the aldehydic substances derived from O3 degradation of AA in the cell-free system. In vitro, O3-degraded AA induced an increase in human peripheral blood polymorphonuclear leukocyte (PMN) polarization, decreased human peripheral blood T-lymphocyte proliferation in response to mitogens, and decreased human peripheral blood natural killer cell lysis of K562 target cells. The aldehydic substances, but not hydrogen peroxide, appeared to be the principal active agents responsible for the observed effects. O3-degraded AA may play a role in the PMN influx into lungs and in decreased T-lymphocyte mitogenesis and natural killer cell activity observed in humans and rodents exposed to O3.
From an excess of fat, diabetics die
Authors: G. Steiner
Journal: JAMA (1989)

In 1927, Joslin<sup>1</sup>prophetically wrote: "I believe the chief cause of premature development of arteriosclerosis in diabetes, save for advancing age, is an excess of fat, an excess of fat in the body (obesity), an excess of fat in the diet, and an excess of fat in the blood. With an excess of fat diabetes begins and from an excess of fat diabetics die, formerly of coma, recently of arteriosclerosis." Despite the seven decades that have passed and the considerable knowledge that has been gained since that time, physicians continue to pay little attention to the control of plasma lipid disorders in their diabetic patients. This is the conclusion reached by Stern and colleagues<sup>2</sup>in this issue ofThe Journal. It is well recognized that coronary artery disease is approximately 2.5 times more common in diabetics than in nondiabetics. The comparable figure for peripheral vascular disease is an
The Diabetic Foot
Authors: Reginald R. Cooper
Journal: JAMA (1994)

The authors of<i>The Diabetic Foot</i>have found it necessary to expand this text in the five years since the fourth edition. The increase in size reflects our growing knowledge about the pathogenesis and management of lower limb problems in diabetic patients. Thanks to educational efforts by multiple specialties, many of the growing and aging diabetic population now understand their disease, the possible complications, the danger of foot lesions, and the absolute necessity for proper foot care to avoid joining the 60 000 with major amputations in the United States each year. The very magnitude of diabetes, occurring in 14 million Americans, 15% of whom develop foot ulcers, and with a cost of $1 billion in direct medical care, warrants still more attention to this increasing problem. Sixteen percent of hospital admissions of diabetics are for foot problems. The authors have continued to direct their efforts to the prime goal
Comparative Histopathology of the Development of Selected Neoplasms of the Liver, Pancreas, and Urinary Bladder in Rodents
Authors: Dante G. Scarpelli
Journal: Environmental Health Perspectives (1988)

The valid extrapolation of carcinogenesis data from one species to another depends, in part, on strong similarities of the metabolic and cellular mechanisms involved in the carcinogenic process and similarities in the nature and behavior of the various lesions that appear during the development of neoplasia between the species involved. Although there are many biological differences between the various rodent species used in carcinogenesis research, there are more similarities, in keeping with the surprising unity of basic cellular and tissue organization and function that is evident throughout biological systems at every level of evolutionary development. An understanding of intraspecies similarities and differences, especially as these modify the morphologic responses of the host to carcinogenic chemicals, is of central importance if carcinogenesis data from one species are to be used to predict carcinogenic risk in another. In this manuscript the histopathology of the various lesions that appear during chemically induced cancer of the liver, pancreas, and bladder in several rodent species has been selected to compare and contrast similarities and differences that exist among them and among the spontaneous premalignant lesions and carcinomas of these organs in humans.
Intracavitary Irradiation of Malignant Brain Tumors
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ingested Foreign Bodies in Childhood
Authors: R. Burkitt
Journal: BMJ (1971)

portant to exclude inhalation of the object.A 4-year-old boy was brought to this department recently thought to have ingested a foreign body, "ingestion" being associated with a short bout of coughing.Clinically he showed no adverse effects and he was not x-rayed.Three days later his mother brought him back stating that he seemed unwell in himself and appeared to be breathless.X-rays showed a foreign body lodged in the right main bronchus.May we therefore suggest the following indications for x-raying children suspected of ingesting foreign bodies when presenting
Biological defense research: charting a safer course
Authors: J. A. Jacobson
Journal: JAMA (1989)

THE ARMY'S research on biological agents has escalated dramatically since 1980 and raised concerns in the scientific and medical communities about its propriety, utility, and safety. In an article in this issue ofThe Journalregarding chemical and biological warfare, Orient<sup>1</sup>asks whether defenses should be researched. Defenses are, of course, being researched, but some of this research may undermine the 1972 Biological and Toxin Weapons Convention, which bans the use and development of biological weapons. We will comment on some aspects of the current US Biological Defense Research Program and suggest ways that physicians can be sure that research on biological agents, if it is necessary, is safe, appropriate, and likely to decrease rather than increase the threat of a biological arms race. We propose changes in responsibility for some biological defense research, more openness in the conduct of research, and reinforcement of the 1972 treaty. The basis
The PRaCTICaL study of nurse led, intensive care follow-up programmes for improving long term outcomes from critical illness: a pragmatic randomised controlled trial
Journal: BMJ (2009)

Objectives To test the hypothesis that nurse led follow-up programmes are effective and cost effective in improving quality of life after discharge from intensive care.Design A pragmatic, non-blinded, multicentre, randomised controlled trial.Setting Three UK hospitals (two teaching hospitals and one district general hospital).Participants 286 patients aged ≥18 years were recruited after discharge from intensive care between September 2006 and October 2007.Intervention Nurse led intensive care follow-up programmes versus standard care.Main outcome measure(s) Health related quality of life (measured with the SF-36 questionnaire) at 12 months after randomisation.A cost effectiveness analysis was also performed.Results 286 patients were recruited and 192 completed one year follow-up.At 12 months, there was no evidence of a difference in the SF-36 physical component score (mean 42.0 (SD 10.6) v 40.8 (SD 11.9), effect size 1.1 (95% CI -1.9 to 4.2), P=0.46) or the SF-36 mental component score (effect size 0.4 (-3.0 to 3.7), P=0.83).There were no statistically significant differences in secondary outcomes or subgroup analyses.Follow-up programmes were significantly more costly than standard care and are unlikely to be considered cost effective.Conclusions A nurse led intensive care follow-up programme showed no evidence of being effective or cost effective in improving patients' quality of life in the year after discharge from intensive care.Further work should focus on the roles of early physical rehabilitation, delirium, cognitive dysfunction, and relatives in recovery from critical illness.Intensive care units should review their follow-up programmes in light of these results.
THE JUMPERS OF MAINE REVISITED
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal