tbuckley/cabot-search huggingface dataset:
Dietary Modifiers of Carcinogenesis
Authors: Lenore Kohlmeier, Neal Simonsen, Kathleen Mottus
Journal: Environmental Health Perspectives (1995)

Dietary components express a wide range of activities that can affect carcinogenesis.Naturally occurring substances in foods have been shown in laboratory experiments to serve as dietary antimutagens, either as bioantimutagens or as desmutagens.Dietary desmutagens may function as chemical inactivaters, enzymatic inducers, scavengers, or antioxidants.Dietary components may also act later in the carcinogenic process as tumor growth suppressors.Examples of dietary factors acting in each of these stages of carcinogenesis are presented, and potential anticarcinogens such as the carotenoids, tocopherols, phenolic compounds, glucosinolates, metal-binding proteins, phytoestrogens, and conjugated linoleic acid are discussed.Individual foods typically contain multiple potential anticarcinogens.Many of these substances can influence carcinogenesis through more than one mechanism.Some substances exhibit both anticarcinogenic and carcinogenic activity in vitro, depending on conditions.Epidemiologic research indicates that high fruit and vegetable consumption is associated with lower cancer risk.Little research has focused on the effects of single substances or single foods in man.Realization of the potential of foodborne substances to reduce the human burden of cancer will only be achieved with better measurement of dietary exposures and funding of multidisciplinary research in this area commensurate with its importance.
Corrigendum
Journal: BMJ (1935)

MEA THE BRRTISN -----JOURNAL~~~~_ and if X. Y. Z. can show that his total expenses fall within that category, the excess is deductable in his assess- ment.The car is apparently used privately to some extent, and it may be difficult to establish the contention that the services of -a chauffeur are " necessary," seeing that the mileage rate implies that, in the view of the employer, the services of a chauffeur are not " necessary " to the carrying out of the duties.There may be exceptional circumstances in the case; if not, our correspondent's prospects of success in an appeal are slender.Purchase of Lease and Practice A. N." took out a lease for a branch surgery for which he paid £78.Is this allowable as practice expenditure?Similarly, is the payment of brokerage (calculated on the quarterly takings for three years) in connexion with the purchase of a practice allowable?*** In each case the expense was incurred in acquiring a capital asset 'or in extending the practice, and con- sequently both have to be regarded for income-tax purpcses as capital expenditure and are not allowable.
Ecthyma Gangrenosum
Authors: Anna K M Korte, Josephine M Vos
Journal: New England Journal of Medicine (2017)

A 21-year-old woman with acute myeloid leukemia who was undergoing induction chemotherapy presented with a lesion on her left knee. Blood and wound cultures grew Pseudomonas aeruginosa, and a diagnosis of ecthyma gangrenosum was made.
Mycologist Helpful in Mold Allergy Diagnosis
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Jahrbuch für orthopädische Chirurgie.
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 108: Effect of a Medical Decision Support Device on Quality of Basic Life Support
Authors: Elizabeth A Hunt, Kristen L Nelson, Margaret Heine, Nicole A Shilkofski
Journal: Circulation (2007)

Background: As cardiopulmonary arrest (CPA) can occur anywhere, laypersons may need to initiate CPR. However, recent literature reveals the quality of basic life support (BLS) provided during CPA is poor. There is increasing interest in whether devices can support laypeople, as well as others, to manage medical emergencies. Methods: We performed a prospective, randomized, controlled trial of simulated out of hospital CPA in which each subject was asked to manage a standardized event using the Laerdal Resusci-Anne simulator. A study member played a second rescuer to help as directed. The intervention was a device with audiovisual prompts designed to assist with decision making. Study subjects included laypeople and nursing and medical students. The primary outcome measure was the proportion of subjects who performed compressions and ventilations at a 30:2 ratio. Secondary outcome measures were proportion of subjects who insisted on switching roles with the second rescuer after 2 minutes and other measures of quality BLS. Results: Thirty-one subjects were enrolled, 16 in the intervention arm and 15 in the control arm, with similar baseline characteristics. Subjects in the intervention arm were more likely to perform compressions to ventilations at a ratio of 30:2 than controls, [15/16 (94%) vs. 4/15 (27%), p&lt;0.001], even with stratification by rescuer background: laypeople [8/9 (89%) vs. 0/4 (0%), p=0.02], medical or nursing student [7/7 (100%) vs. 4/11 (36%), p=0.01]. Intervention subjects were also more likely to insist that the second rescuer switch roles with them than controls, [12/16 (75%) vs. 2/15 (13%), p=0.001]. However, there was a delay in mean time (± standard deviation) to initiation of compressions in the intervention arm, [159.5 (±53) vs. 78.2 (± 20) seconds, p &lt; 0.001] and the no-flow fraction was very high in both arms, [72.2% (± 0.1) vs. 75.4 (± 0.8), p = 0.35]. Conclusions: The device resulted in a behavior change as intervention subjects were more likely to perform 30:2 and switch providers. Unfortunately, the device slowed the initial response time. These results are promising, but future studies should concentrate on decreasing latency time, periods without compressions and possible incorporation into automated external defibrillators.
Durability of biochemical improvements through six years of open label treatment with obeticholic acid in patients with primary biliary cholangitis who did not achieve the poise criteria
Authors: Gideon Hirschfield, Marco Carbone, David Jones, Bettina Hansen, Andreas E Kremer, Michael Trauner, Alexander Liberman, Elizabeth Smoot Malecha, Leigh MacConell
Journal: Journal of Hepatology (2020)
BIOMECHANICS AND DRUG ELUTION IN ARTERIAL RESPONSE TO PERIPHERAL STENTS: AN OCT COMPARATIVE STUDY OF 3 CONTEMPORARY STENTS IN BALLOON-PREDILATED FEMORAL ARTERIES OF FAMILIAL HYPERCHOLESTEROLEMIC SWINE
Authors: Yanping Cheng, Jennifer McGregor, Gerard Conditt, Miguel Montero-Baker, Greg Kaluza, Juan Granada
Journal: Journal of the American College of Cardiology (2018)
A phenotype combining hidradenitis suppurativa with Dowling-Degos disease caused by a founder mutation in <i>PSENEN</i>
Authors: M. Pavlovsky, O. Sarig, M. Eskin-Schwartz, N. Malchin, R. Bochner, J. Mohamad, A. Gat, A. Peled, A. Hafner, E. Sprecher
Journal: British Journal of Dermatology (2018)

Dowling‐Degos disease is rare genetic disorder that starts to appear during puberty, featuring abnormal skin colouring (pigmentation) most commonly in the folds of the skin, known as flexural areas. Familial hidradenitis suppurativa is also a rare genetic disorder that features recurrent boils in flexural areas. It usually starts to appear around puberty. Sometimes the two disorders co‐exist in the same person. Defects in the same gene, called PSENEN, were recently found in patients who have both hidradenitis suppurativa and Dowling‐Degos. The product of PSENEN is a protein that is a part of a complex named NOTCH that plays an important role in the development of the skin and other organs. Here we report 4 Jewish Ashkenazi families who presented with clinical features characteristic of both disorders. All patients were found to carry the same gene defect in PSENEN, a defect that was never shown before. We checked the area around the gene and found it to be the same in all patients. This means that all patients got the mutation from a common ancestor. In the next step of our research project we wanted to show that defect in PSENEN actually influences NOTCH. We used cells from a patient and compared it to cells from a healthy person. We showed that there is less PSENEN in the cells of the patients, and when we insert a special element inside the cells that makes them glow when NOTCH is active, patient cells glow less than cells from healthy people. In conclusion, in this present study we showed a new genetic defect in PSENEN that can cause two diseases at once: Dowling‐Degos disease and hidradenitis suppurativa. We also show that NOTCH is important in both of these diseases.
MODERN MEDICAMENT.
Authors: C. B. MEDING
Journal: JAMA (1892)

Of the physician's duty toward his patient much has been set forth by the press, medical, religious, and secular. It remains for our body to present and enlarge upon as well as to impress one another with the importance of our duty toward ourselves. Though often lost sight of, it is still of first magnitude, morally, professionally, and financially. However strongly it may be held that professional life has in consciousness its own reward, however often it may be reiterated that worldliness is no part of our creed, the truth remains that, in common with the rest of humanity, we must live and must fight for life. We have enemies, we have opposition and competition, antagonistic factors that will of necessity be victors or vanquished. Not a few of us here present have found that the voyage is not over an altogether smooth sea, is not free from storm and
Co-Existence of LMPP-Like and GMP-Like Leukemia Stem Cells In Acute Myeloid Leukemia
Authors: Nicolas Goardon, Emmanuele Marchi, Lynn Quek, Anna Schuh, Petter Woll, Adam Mead, Kate Alford, Amanda Gilkes, Kheira Beldjord, David Bowen, Graham Standen, Sally Killick, Hannah Hunter, Steven Knapper, Lisa Robinson, Alex Sternberg, James D Cavenagh, Paul Virgo, Mike Griffiths, Elizabeth A. Macintyre, Charles Craddock, Alan Burnett, Tariq Enver, Sten Eirik W Jacobsen, Catherine Porcher, Paresh Vyas
Journal: Blood (2010)
Endocrine Adenomatosis and Peptic Ulcer in a Large Kindred
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bacteria and the Telephone
Journal: JAMA (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Depression and CD4 decline
Authors: D. C. Barrett
Journal: JAMA (1994)

<h3>To the Editor.</h3> —Our recent findings on the relationship between depression and change in CD4 cell count<sup>1</sup>and Dr Lyketsos and colleagues'<sup>2</sup>failure to replicate our findings have added to the controversy concerning psychological distress and disease progression. Space limitations allow us to address only a few of the issues raised by the differences in articles and by the Editorial by Drs Perry and Fishman.<sup>3</sup> Perry and Fishman asserted that our significant findings may be a type I error attributable to our smaller sample size. The basis for this assertion is unclear. Smaller sample size diminishes power, thus making it more difficult to find a statistically significant effect (a type II error). Differences in results are therefore likely to be attributable to differences in procedures or in sample characteristics. The procedures of the two studies, though not identical, are similar. The study populations do differ on mean
Commentaire de travail de T. H. Lee et al., pp.106
Journal: Endoscopy (2013)

See also: Primary and revision efficacy of cross-wired metallic stents for endoscopic bilateral stent-in-stent placement in malignant hilar biliary stricturesEndoscopy 2013; 45(02): 106-113DOI: 10.1055/s-0032-1325928
Indications for Operation, in Disease of the Internal Organs.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical Summaries
Journal: Circulation (2008)

Repolarization reserve is an important determinant of the response to contexts involving action potential prolongation, including potassium channel-blocking drugs (both antiarrhythmic agents and compounds with collateral effects on potassium channels), bradycardic drugs, and electrolyte disturbances like hypokalemia and hypomagnesemia.Repolarization reserve is generally attributed to functionally based compensatory increases in potassium currents in response to action potential duration-prolonging tendencies that minimize the resulting action potential prolongation.The possibility that sustained action potential prolongation by potassium channel inhibition may induce remodeling of ion current expression has not been tested.Accordingly, we assessed the effects of sustained rapid delayedrectifier potassium current (I Kr ) inhibition with dofetilide on various cardiac ionic currents in isolated paced/cultured dog cardiomyocytes.Sustained dofetilide exposure led to abbreviated action potential duration and increased repolarization reserve (reduced action potential duration-prolonging response to I Kr blockade), along with increased slow delayed-rectifier current (I Ks ) density.A variety of other currents remained unchanged.The mRNA expression of I Ks subunits was unchanged, but their protein expression was increased, suggesting posttranscriptional regulation.We quantified the musclespecific microRNA subtypes miR-133a and miR-133b, which can posttranscriptionally repress protein expression of the I Ks ␣-subunit KvLQT1.Expression levels of miR-133a and miR-133b were decreased in cells cultured in dofetilide, possibly accounting for KvLQT1 protein upregulation.We conclude that chronic action potential prolongation can cause compensatory upregulation of potassium currents, possibly mediated (at least in part) by microRNA changes, adding the regulation of ion channel expression to the potential mechanisms governing repolarization reserve.Function and malfunction of this system could contribute to factors governing the occurrence of cardiac arrhythmias in repolarization dysfunction paradigms like congenital and acquired long-QT syndromes.See p 992.
Circulation
Authors: Joseph C. Greenfield
Journal: JAMA (1971)

In their book,<i>Circulation</i>, Folkow and Neil have provided students of circulatory physiology with a wellprepared monograph which treats the various aspects of this subject in moderate detail. The material is presented in a succinct manner and is well illustrated. The book was written entirely by the two authors and thus, the presentation is uniform and cohesive. It will be especially valuable to the American reader since it is documented to a major degree from the European literature and provides an easily accessible reference to this material. The book is too detailed for general use by medical students but should be an excellent beginning text for those who wish to acquire more than a minimal knowledge of the circulation. As one would expect from these authors, the best chapters are the three which describe the nervous control of the circulation. As with any monograph of this nature, it is always
Pseudomonas From Whirlpool
Journal: JAMA (1978)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The New York Board of Health.—
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal