tbuckley/cabot-search huggingface dataset:
Impaired autophagic flux mediates acinar cell vacuole formation and trypsinogen activation in rodent models of acute pancreatitis
Authors: Olga A. Mareninova, Kip Hermann, Samuel W. French, Mark S. O’Konski, Stephen J. Pandol, Paul Webster, Ann H. Erickson, Nobuhiko Katunuma, Fred S. Gorelick, Ilya Gukovsky, Anna S. Gukovskaya
Journal: Journal of Clinical Investigation (2009)

The pathogenic mechanisms underlying acute pancreatitis are not clear. Two key pathologic acinar cell responses of this disease are vacuole accumulation and trypsinogen activation. We show here that both result from defective autophagy, by comparing the autophagic responses in rodent models of acute pancreatitis to physiologic autophagy triggered by fasting. Pancreatitis-induced vacuoles in acinar cells were greater in number and much larger than those induced with fasting. Degradation of long-lived proteins, a measure of autophagic efficiency, was markedly inhibited in in vitro pancreatitis, while it was stimulated by acinar cell starvation. Further, processing of the lysosomal proteases cathepsin L (CatL) and CatB into their fully active, mature forms was reduced in pancreatitis, as were their activities in the lysosome-enriched subcellular fraction. These findings indicate that autophagy is retarded in pancreatitis due to deficient lysosomal degradation caused by impaired cathepsin processing. Trypsinogen activation occurred in pancreatitis but not with fasting and was prevented by inhibiting autophagy. A marker of trypsinogen activation partially localized to autophagic vacuoles, and pharmacologic inhibition of CatL increased the amount of active trypsin in acinar cells. The results suggest that retarded autophagy is associated with an imbalance between CatL, which degrades trypsinogen and trypsin, and CatB, which converts trypsinogen into trypsin, resulting in intra-acinar accumulation of active trypsin in pancreatitis. Thus, deficient lysosomal degradation may be a dominant mechanism for increased intra-acinar trypsin in pancreatitis.
Dramatic Responses Seen with TRK Inhibitor
Journal: Cancer Discovery (2017)

Presenting data on 50 of 55 patients with advanced TRK fusion-positive tumors, researchers reported that 76% of patients responded to the selective pan-TRK inhibitor larotrectinib, and 12% of patients experienced complete responses; 93% of responders remain on therapy. The targeted therapy was well tolerated, with just 13% of patients requiring a dose modification. None of the patients discontinued treatment due to adverse events.
Ezekiel
Authors: Rebekka DePew
Journal: Annals of Internal Medicine (2018)

Ad Libitum6 February 2018EzekielRebekka DePewRebekka DePewFrom Vanderbilt University School of Medicine, Nashville, Tennessee.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M17-1296 Audio Reading - “Ezekiel” Audio. Virginia L. Hood, MD, Annals Associate Editor, reads "Ezekiel," by R. DePew. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail First year preclinical we were learning about bonesand I loved them because they heal, as so few thingsever heal. In lecture hall, I would tell my friends aboutmy newfound love of broken bones, how they are notlike the other wounds that scar, like hormone levelsthat overcorrect, cancers that come back. Bones getbroken and reform stronger. Split edges realign anda new matrix is laid down, a building self-sufficient inits own scaffolding.cast of ... Author, Article, and Disclosure InformationAffiliations: From Vanderbilt University School of Medicine, Nashville, Tennessee.Current Author Address: Rebekka DePew; e-mail, [email protected]com. PreviousarticleNextarticle Advertisement Audio Reading - “Ezekiel” Audio. Virginia L. Hood, MD, Annals Associate Editor, reads "Ezekiel," by R. DePew. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 6 February 2018Volume 168, Issue 3Page: 169KeywordsBoneBone fractureDustEmotionsHormonesOsteoporosisScarsSpine ePublished: 6 February 2018 Issue Published: 6 February 2018 Copyright & PermissionsCopyright © 2018 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Abstract 18275: Serial Echocardiography Demonstrates Reversible Myocardial Dysfunction After Resuscitation From Cardiac Arrest
Authors: Jacob C Jentzer, Asher Shafton, Meshe Chonde, Gavin Hickey, Hussein Abu-Daya, Andrew Althouse, Jon Rittenberger
Journal: Circulation (2015)

Introduction: Reversible myocardial dysfunction after cardiac arrest (CA) appears common, but few studies have performed serial echocardiography in patients resuscitated from CA. Hypothesis: Evidence of reversible LV systolic dysfunction will be identified on serial echocardiography early after CA. Methods: We prospectively performed repeat transthoracic echocardiography (TTE) between 72 and 96 hours after CA in 17 patients who had undergone an initial TTE within 24 hours after CA. We compared mean values derived from 2D measurements, LVEF, spectral Doppler of mitral inflow and LV outflow, and peak systolic and early diastolic tissue Doppler of the mitral annulus between echocardiograms using paired t-tests. Mean changes in TTE parameters were compared between hospital survivors and non-survivors using paired t-tests. Results: In these 17 subjects, there were significant increases in LV fractional shortening (+0.12, p = 0.028), LV outflow tract velocity-time integral (+3.82cm, p = 0.002) and both septal (+2.6, p = 0.016) and lateral (+1.8, p = 0.014) mitral annular systolic tissue Doppler (s’) velocities on repeat TTE. There were nonsignificant increases in estimated LVEF (+11.25%, p = 0.063) and TAPSE (+0.32, p = 0.065) between initial and repeat TTE. Other TTE parameters did not differ significantly between initial and repeat TTE, although not all parameters were available in all patients. Hospital non-survivors had a significant decrease in their LV end-systolic diameter (-0.68cm, p = 0.0161) and a non-significant decrease in their LV end-diastolic diameter (-0.4cm, p = 0.0549) on repeat TTE, whereas survivors did not. Changes in both septal (6 vs. 1.5, p = 0.0044) and lateral (3.67 vs. 0.88, p = 0.0161) mitral annular s’ velocities were higher in non-survivors. Other changes in echocardiographic parameters did not significantly differ between survivors and non-survivors. Conclusions: LV fractional shortening, LV outflow tract velocity time integral and mitral annular s’ velocities increase between 24 hours and 72-96 hours after CA, consistent with reversible myocardial dysfunction. Hospital non-survivors had greater changes in LV dimensions and mitral annular s’ velocities between 24 hours and 72-96 hours than hospital survivors.
AMA's Bureau of Investigation exposed fraud
Authors: T. Ziporyn
Journal: JAMA (1985)

The American Medical Association has had a longstanding interest in debunking patent medicines and exposing quacks. Besides its campaign against patent medicine advertisement in the early 20th century (see main story), in fact, for many years the AMA's Bureau of Investigation analyzed suspicious nostrums and alerted both the medical profession and the public to unscrupulous promoters. Originally headed by Arthur J. Cramp, MD, the bureau was formed in 1906 under the name "Propaganda Department." (Until about 1920, "propaganda" simply meant information.) This department prepared abstracts of government reports on the chemical composition of nostrums seized in interstate commerce. It also arranged to have many widely advertised nostrums examined in the AMA's Chemical Laboratory and published the results inThe Journal. Later years brought increased activity to the department, whose name was changed to the Bureau of Investigation in 1925. The bureau added other forms of quackery to its investigations and
Discovering the individual
Authors: Z. Danilevicius
Journal: JAMA (1978)

Historians will probably call the 20th century an age of scientific progress and enlightenment. They will also call it the century that brought enormous disregard for human life, a century that will be remembered for its wars, rebellions, and subsequent loss of millions of innocent lives. All that is good in man has been accentuated, all that is creative in him has been awakened, but much that is bad in him has triumphed. What a paradox! Understandably, these events have caused many to regard man's future with some trepidation. Jean Hamburger,<sup>1</sup>however, does not share this fear. A pure scientist, teacher, pioneer in kidney transplantation, and prolific writer, he sees hope for mankind. In his new book,<i>Discovering the Individual</i>,<sup>1</sup>Hamburger presents a fascinating description of recent advances in immunology and genetics. From these he draws some philosophical conclusions concerning built-in or genetic possibilities for the action of
Midnight Supper
Authors: Jack Coulehan
Journal: Annals of Internal Medicine (2010)

Ad Libitum7 December 2010Midnight SupperJack Coulehan, MD, MPHJack Coulehan, MD, MPHFrom Setauket, NY 11733.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-153-11-201012070-00008 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Cold spaghetti and thirty two ouncesof Coke at midnight supper. A litteredfoursome, in which the first announcedthere was another hit to work up. The embitteredsecond stabbed his plastic tray with a pen.The third intern shuffled through a stackof index cards. His wife's father in Johnstownhad just died of cancer. The last attackeda stale Portuguese roll with his fork.Gears grinding, motors turning, but nothinghappening. The ozone-like smell of stale work.Did they suffer from sleep deprivation?Thirty-six on, twelve off. What a sublimemethod of learning the value of time. Author, Article, and Disclosure InformationAffiliations: From Setauket, NY 11733.Current Author Address: Jack Coulehan, MD, MPH, 4 Townsend Court, Setauket, NY 11733. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 7 December 2010Volume 153, Issue 11Page: 750KeywordsSleep deprivationSmell ePublished: 7 December 2010 Issue Published: 7 December 2010 Copyright & PermissionsCopyright © 2010 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Efficacy of low-frequency positive-pressure ventilation-extracorporeal CO2 removal.
Authors: F Brunet, J P Mira, J F Dhainaut, J Dall'ava-Santucci
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

"Efficacy of low-frequency positive-pressure ventilation-extracorporeal CO2 removal.." American journal of respiratory and critical care medicine, 151(4), pp. 1269–1270
Detained
Authors: Merlys Rodriguez-Hernandez, Tara C. Pilato, Kayleigh A. Yerdon, Ian M. Kysel, Faten Taki, Stephen Yale-Loehr, Gunisha Kaur, Alison E. Burke, Natalie Koscal
Journal: New England Journal of Medicine (2021)

This Graphic Perspective tells the story of a Cuban doctor who, having been targeted by her government as a dissident, seeks asylum in the United States, only to find herself trapped in a detention center for many months during the Covid-19 pandemic.
Involvement of Cytochrome P450, Glutathione S-Transferase, and Epoxide Hydrolase in the Metabolism of Aflatoxin B 1 and Relevance to Risk of Human Liver Cancer
Authors: F. Peter Guengerich, William W. Johnson, Yune-Fang Ueng, Hiroshi Yamazaki, Tsutomu Shimada
Journal: Environmental Health Perspectives (1996)
Complement Activation and Inhibition in Myocardial Ischemia and Reperfusion Injury
Authors: J. Homeister
Journal: The Annual Review of Pharmacology and Toxicology (1994)

Heme oxygenases (HO) catabolize free heme, that is, iron (Fe) protoporphyrin (IX), into equimolar amounts of Fe2+, carbon monoxide (CO), and biliverdin. The stress-responsive HO-1 isoenzyme affords protection against programmed cell death. The mechanism ...Read More
Problem Children
Authors: Ida Mae D.
Journal: JAMA (1979)

MEN and women often consult physicians about problems with their spouse, but problems with their children seem to be in a different category. Any defect—emotional or physical—in our offspring causes a terrible feeling of guilt. Most good parents somehow have been led to believe that they should be able to control every aspect of their children's development. Because of this sensitivity, it takes an understanding physician to announce that drug abuse may be the cause of some of the problems that bring the frantic family to his office. Understandably, many physicians hesitate to convey their suspicions to the parents or even to discuss them with the patient. Many a young patient has already become adroit at veiling the true situation. Often the physician is at a loss to suggest a remedy to the family. For years physicians have referred families with the problem of alcoholism to Alcoholics Anonymous and Al-Anon.
Medical genetics
Authors: C. T. Caskey
Journal: JAMA (1990)

Medical genetics can be said to be the first subspecialty of molecular medicine. Rapid incorporation of recombinant DNA technology into the clinical diagnostics of genetic disease has been the modus operandi of the field. At the 1989 American Society of Human Genetics meeting, more than 60% of manuscripts were molecular descriptions of disease genes. Application of DNA-based diagnostics has been accelerated by development of the polymerase chain reaction. Yeast artificial chromosome vectors and other methods for cloning large DNA segments and data flow from the Human Genome Initiative will accelerate disease gene identifications far beyond the expectations of 1 or 2 years ago. In only about 100 of the more than 3000 known heritable diseases has the mutant gene been isolated.<sup>1</sup>We anticipate identification of all 50 000 to 100 000 human genes within 10 to 15 years. To accommodate the application of DNA technology for molecular medicine, we
THE SURGERY OF THE THYROID FROM A NEUROLOGIC STANDPOINT.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hematopoietic Stem Cell Function in β-Thalassemia Is Impaired and Is Rescued By Targeting the Bone Marrow Niche
Authors: Annamaria Aprile, Alessandro Gulino, Isabella Villa, Stefano Beretta, Ivan Merelli, Alessandro Rubinacci, Maurilio Ponzoni, Sarah Marktel, Claudio Tripodo, Maria Rosa Lidonnici, Giuliana Ferrari
Journal: Blood (2019)
The role of adhesion molecules in the recruitment of hepatic natural killer cells (pit cells) in rat liver
Authors: D Luo
Journal: Hepatology (1996)

Previous studies showed that blood large granular lymphocytes (LGL), which possess natural killer (NK) activity, develop within rat liver sinusoids into high-density (HD) and subsequently into low-density (LD) pit cells which show an increasing level and spectrum of tumor cytotoxicity. In this study, we investigated the role of adhesion molecules, such as CD2, CD11a, CD18, and CD54 in the recruitment of pit cells to the liver. Immunostaining for electron microscopy, and two color flow cytometry showed that most pit cells expressed CD2, CD11a, CD18, and CD54. After intravenous injections into rats with anti-CD2, anti-CD11a, and anti-CD18 antibodies, the number of pit cells per square millimeter in frozen sections of liver tissue decreased. Treatment of rats with zymosan increased the number of pit cells fivefold, whereas subsequent treatment with anti-adhesion-molecule antibodies resulted in approximately 60% lower number of pit cells. Anti-CD54, supposed to block CD54 expression on sinusoidal endothelial cells, also decreased the number of pit cells. The number of blood LGL was, however, not affected by these antibodies. These results indicate that blocking of CD2, CD11a, CD18, and CD54 antigens on blood LGL and/or liver endothelium decreased the number of pit cells in the liver. These adhesion molecules therefore play an important role in the recruitment of pit cells in the liver.
Border Lines
Authors: Margaret Divish
Journal: Annals of Internal Medicine (2000)

Ad Libitum6 June 2000Border LinesMargaret Divish, MDMargaret Divish, MDCharlotte Medical Clinic; Charlotte, NC 28226 (Divish)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-11-200006060-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail She oozesBlack, sticky sludgeInto my exam roomPoundingRelentlessly.Her needs, her pain, her lonelinessWashing against my wallsSeeping over the top, underneath the foundationFinding the cracks and spilling throughMelting the mortar not yet dry.Crumbling the stones.Her burden licks at my ankles, climbs to my knees,Pours onto my lap.In the midst of the rubble she stares at me.This childTrapped in the pain of the wounds,Which are never her fault,Never her responsibilityThose people—her parents, husband, daughter, the judge, the police,The other doctors.Someone must care for these wounds.She oozes up to my chest, my neckAnd over my head. Author, Article, and Disclosure InformationAffiliations: Charlotte Medical Clinic; Charlotte, NC 28226 (Divish)Corresponding Author: Margaret Divish, MD, Charlotte Medical Clinic, 7810 Providence Road, Suite 103, Charlotte, NC 28226. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoClinical Utility of Blood Cultures Drawn from Indwelling Central Venous Catheters in Hospitalized Patients with Cancer Jeffrey A. DesJardin , Matthew E. Falagas , Robin Ruthazer , John Griffith , Dorothy Wawrose , David Schenkein , Kenneth Miller , and David R. Snydman Metrics 6 June 2000Volume 132, Issue 11Page: 921KeywordsAnklesKneesSludgeThorax ePublished: 15 August 2000 Issue Published: 6 June 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Transactions of the Michigan State Medical Society.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TOC
Authors: Anne Van Kempen, Johannes Romijn, An Ruiter, Erik Endert, Gerrit Weverling, Johanna Kok, Hans Sauerwein, David Leaf, Jennifer Altomonte, Sonal Harbaran, Anja Richter, Hengjiang Dong, Nelly Mauras, Annie Rini, Susan Welch, Brenda Sager, Suzanne Murphy, Samuel Murray, Eugenia Duarte, Elsa Brochmann, Marta Santure, Maryse Pitre, Andre ´nadeau, He ´le `ne Bachelard, Denise Papineau, Annemarie Gagnon, Alexander Sorisky, Michael Macdonald, Giuseppe Licata, Tiziana Chiara, Anna Licata, Giovanni Triolo, Christiano Argano, Antonio Pinto, Gaspare Parrinello, Salvatore Corrao, Giovanni Duro, Rosario Scaglione, J Gonza ´lez-Barranco, J Rı ´os-Torres, L Castillo-Martı ´nez, J Lo ´pez-Alvarenga, C Aguilar-Salinas, C Bouchard, J Depre, Debendranath Dey, Satya Medicherla, Partha Neogi, Maya Gowri, Jin Cheng, Coleman Gross, Somesh Sharma, Gerald Reaven, Bishwajit Nag, Hirohito Sone, Hitoshi Shimano, Hiroyuki Ebinuma, Akimitsu Takahashi, Yoshihiro Yano, Tada Iida, Hiroaki Suzuki, Hideo Toyoshima, Yasushi Kawakami, Yukichi Okuda, Yuichi Noguchi, Koji Ushizawa, Kazunori Saito, Nobuhiro Yamada, Yuval Heled, Yair Shapiro, Yoav Shani, Dani Moran, Leah Langzam, Liora Braiman, Sanford Sampson, Joseph Meyerovitch, Marius Carstensen, Claus Thomsen, Kjeld Hermansen, Ana Wa, Jordi Ordo ´n ˜ez-Llanos, Rosa Arcelus, Rosa Bonet, Oscar Jorba, Jose Sa ´nchez-Quesada, Esther Alonso, Josep Julve, Antonio Pe ´rez, J Van Wijk, C Halkes, D Erkelens, M Castro Cabezas, C Courtney, A Atkinson, C Ennis, B Sheridan, P Bell, Paul Poirier, Peter Bogaty, Caroline Garneau, Claudette Fortin, Jean-G Dumesnil, A Xavier, M Garo ´falo, R Migliorini, I Kettelhut, Martin Muurling, Ronald Mensink, Hanno Pijl, Louis Havekes, Peter Voshol
Journal: Metabolism (2003)
Confirmation of brain death at bedside by isotope angiography
Authors: J. M. Goodman
Journal: JAMA (1977)

Documentation of the absence of cerebral circulation is useful as a confirmatory test of brain death. Intravenous isotope angiography performed at the bedside with a mobile γ camera is a safe, convenient, rapid, reliable, and easily understood method of proving the absence of cerebral blood flow that occurs in brain death. (<i>JAMA</i>238:966-968, 1977)
Wallet Sciatica
Authors: David R. Cooper
Journal: JAMA (1978)

<h3>To the Editor.—</h3> I read with great interest the letter by Elmar G. Lutz, MD, regarding credit-card-wallet sciatica (240:738, 1978). As an orthopedic surgeon I find this syndrome most intriguing. After reading the letter I started asking patients with sciatic complaints on what side they carried their wallets. When the wallet was on the side of the complaint, I made the patient remove the wallet and allow me to inspect the contents. To my surprise a number of patients had a large amount of green currency, which was obviously causing the wallet to bulge and was giving them the extreme symptoms they described. I simply removed the green currency from the patient's wallet and put it in my own wallet Patients were extremely happy to find that their symptoms had been relieved. Not only do patients find this rewarding, but I also find it so, except for one small problem.