tbuckley/cabot-search huggingface dataset:
Insulin-like growth factor-1 enhanced expression of sarcoplasmic reticulum Ca2+-ATPase in cultured cardiomyocytes of cardiomyopathic hamsters Tomoko Nao, Tomoko Ohkusa, Masae Suetsugu, Jutaro Yamada, Shigeki Kobayashi, Masafumi Yano, Masunori Matsuzaki. The Second Department of Internal Medicine, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan
Journal: Journal of the American College of Cardiology (2001)
Not Anon
Authors: J. McCracken
Journal: BMJ (1992)

investigate the aetiology.We agree with A FThe authors state that pharmacy based trials referred to, giving optimal and instantaneous Mellon and colleagues about the usefulness of conforming to the European Commission's information.urine microscopy as an aid to diagnosing infection, guidelines for good clinical practice are possible.When these sensors and monitors go to the but we however advise caution when dealing with Compliance with some of the stipulations of the community it is paramount that those who hand children,' patients with a self induced diuresis, and guidelines, however, would be problematic.For them out fully educate the users in their use.These patients with vaginitis or cervicitis.' example, it is necessary to check case record forms moves should prevent further events similar to that Steve Higgins and Eboo Versi preach, wisely, with source documents, such as patients' notes.' reported by Emery and colleagues.that patients should have other causes of urethral This ensures that the record form accurately JASPERIEN MEINHARDT symptoms investigated, and we do not disagree.represents the facts.Unless pharmacists keep Graseby Medical, We, however, took a pragmatic approach, realising separate notes on individual patients such valida-Watford, that this was probably a low risk population' and tion would be impossible.Hertfordshire WD2 4LG that a sexual history could be used as a screeningThe guidelines state that the investigator is IEmrJLTalrM,CpetrRWieA.pna
Epidemic faintness and syncope in a school marching band
Authors: R. J. Levine
Journal: JAMA (1977)

On Sept 21, 1973, during and following a football game at which they had participated, 57 members of an Alabama high school marching band (and one accompanying adult) experienced an illness characterized by headache, nausea, weakness, or dizziness. Six girls fainted. Thirty-six students were treated at a hospital emergency room. Those who had played wind instruments and had worn heavier uniforms including an impermeable plastic jacket overlay were affected earlier and more frequently than the others. Several organic causes were examined in an epidemiologic investigation and considered unlikely to explain the epidemic. Female preponderance, a bimodal epidemic curve, hyperventilation, relapses, and clinical features characterized by subjective complaints in the absence of physical findings suggested a syncopal reaction to heat exacerbated and propagated by mass hysteria. (<i>JAMA</i>238:2373-2376, 1977)
Haemophilus influenzae type B resistant to ampicillin. A report of two cases
Authors: W. Khan
Journal: JAMA (1974)

Recently, two infants with severe infections due to ampicillin-resistant strains of<i>Haemophilus influenzae</i>type B were treated at Children's Hospital National Medical Center. In both cases, it was necessary to change therapy to chloramphenicol. One patient with meningitis died while the second with bacteremia and pneumonia recovered. A survey of 60 recent isolates of<i>H influenzae</i>type B in the Washington community showed that 10% were ampicillin-resistant. The enzyme produced by these resistant strains was found to be a β-Iactamase. Careful appraisal is now necessary to decide whether ampicillin is the drug of choice as initial therapy in<i>H influenzae</i>meningitis in pediatric patients. (<i>JAMA</i>229:298-301, 1974)
Impact of surveillance among patients with resected pancreatic cancer following adjuvant chemotherapy.
Authors: Selina Wong, Lovedeep Gondara, Daniel John Renouf, Howard John Lim, Sharlene Gill
Journal: Journal of Clinical Oncology (2020)

768 Background: Pancreatic adenocarcinoma carries a poor prognosis and high risk of recurrence even after surgery and adjuvant chemotherapy (AC). Guidelines recommend against routine surveillance imaging due to lack of evidence supporting a survival benefit. With current first-line chemotherapy options, it is unclear whether surveillance scans allow for early detection of asymptomatic disease and therefore an opportunity to offer fit patients chemotherapy. We describe the patterns of surveillance in patients followed at a Canadian provincial cancer agency and determine whether routine imaging after AC is associated with receipt of palliative chemotherapy (PC). Methods: A retrospective review was completed to identify patients treated at British Columbia (BC) Cancer centres between January 1, 2010 and December 31, 2016 who had undergone curative intent resection and received at least one cycle of AC. Baseline characteristics, number of scans done after completing AC to recurrence, and PC were collected. Logistic regression analysis was performed. Results: A total of 151 patients followed at BC Cancer were identified. Patients who recurred within 28 days after AC were excluded, leaving 142 patients, of which 115 patients had recurrence. We defined 2 cohorts based on number of scans done between completion of AC and recurrence: those with 0-1 scans were “symptomatic” recurrences (22 patients, median age 68y, 64% female, and 91% node-positive) and those with &gt; 1 scan were “surveillance” recurrences (93 patients, median age 64y, 43% female, and 81% node-positive). Patients who underwent surveillance scans were more likely to receive PC at time of recurrence, though statistical significance was not reached (OR 2.11, 95% CI 0.75-6.58, p = 0.17). Conclusions: Despite guidelines, the majority of patients treated in BC underwent surveillance imaging. Within the limits of our sample size, we demonstrated a trend towards increased likelihood of receiving PC in patients who receive surveillance scans following AC. With efficacious PC options available, studies to determine whether receipt of PC in asymptomatic recurrences detected on imaging translates into improved survival and/or quality of life are warranted.
Leukopenia secondary to sulfadiazine silver
Authors: G. L. Fraser
Journal: JAMA (1979)

SULFADIAZINE silver 1% cream has been available in the United States since 1973 for the topical treatment of burns. This bactericidal agent acts on the cell membranes and cell walls of a variety of Gram-positive and Gram-negative bacteria as well as on yeast. Its relative freedom from appreciable side effects such as electrolyte and acid-base disturbances, staining, and pain on application has contributed to its popularity. Rash (which responds to antihistamine therapy), fever, tachycardia, and leukocytosis occur infrequently. More serious in nature is the possibility that the hematologic side effects of the sulfonamides in general could be expected with sufficient systemic absorption of sulfadiazine silver. Leukopenia associated with sulfadiazine silver is one hematologic reaction that has only recently been recognized. It is a relatively common occurrence with an incidence of 3% to 5%.<sup>1,2</sup>The scarceness of information in the literature describing this possible drug-induced reaction prompted our report. <h3>Report</h3>
Secondary Survey
Authors: Meg Verrees
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pronouncements
Authors: Stephen Thomas Harvey
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 3056: Ischemia on Presentation Stratifies Mortality Risk in Surgery for Acute Type A Dissection
Authors: John G Augoustides, Arnar Geirsson, Wilson Y Szeto, Lisa Walsh, Brittany Cornelius, Alberto Pochettino, Joseph E Bavaria
Journal: Circulation (2007)

Introduction: The mortality risk of surgery for acute type A dissection (ATAD) depends on the clinical presentation in published risk models. The identified risk factors predominantly relate to preoperative ischemia whether generalized due to systemic hypotension and/or regional due to aortic branch occlusion. A focus on preoperative ischemia might further clarify mortality risk after surgery for ATAD. Hypothesis: Ischemia, whether generalized (due to systemic hypotension) and/or regional (due to local arterial malperfusion), stratifies mortality risk after operative repair of ATAD. Methods: With IRB approval, all patients undergoing operative repair of ATAD (January 1993 – December 2004) were studied. Perioperative data of interest were abstracted from the medical records and archived electronically. The standardized operative protocol included aortic arch repair with deep hypothermic circulatory arrest and retrograde cerebral perfusion. Statistical significance was defined as a probability value of &lt; 0.05. Results: The study cohort = 221. Average age was 61.6 ± 15.2 years. The cohort was divided into 2 groups: ischemia 42.1% (93/221) and no ischemia 57.9% (128/221). The ischemia subgroup was further divided as follows: generalized 36.6% (34/93); regional 41.9% (39/93); both 21.5% (20/93). Thirty-day mortality was 12.7% (28/221)): 85.7% (24/28) of all deaths were in the ischemic subgroup (p&lt;.05). Mortality was 8.3 fold higher in the presence of ischemia: ischemia 25.8% (24/93) versus no ischemia 3.1% (4/128) (p&lt;.05). The mortality in ischemia subgroups was as follows: generalized 17.6% (6/34); regional 25.6% (10/39); and, both 40% (8/20). All intraoperative deaths occurred in the ischemia group [17.8%(5/28) of all deaths]. Causes of death were grouped as follows: neurological 7/28 (25%: all in ischemia group); cardiac 7/28 (25%: 6/7 in ischemia group); bleeding 3/28 (10.7%: all in ischemia group); multisytem organ failure 11/28 (39.3%: 8/11 in ischemia group). Conclusions: Preoperative ischemia is the major risk for mortality after operative repair for ATAD. Perioperative interventions to minimize ischemia and optimize organ protection should reduce the high mortality in the subgroup with ischemia on presentation.
URIC ACID DIATHESIS IN CHILDREN.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Olaparib tablets as maintenance therapy in patients with platinum-sensitive relapsed ovarian cancer and a BRCA1/2 mutation (SOLO2/ENGOT-Ov21): a final analysis of a double-blind, randomised, placebo-controlled, phase 3 trial
Authors: Andrés Poveda, Anne Floquet, Jonathan A Ledermann, Rebecca Asher, Richard T Penson, Amit M Oza, Jacob Korach, Tomasz Huzarski, Sandro Pignata, Michael Friedlander, Alessandra Baldoni, Tjoung-Won Park-Simon, Kenji Tamura, Gabe S Sonke, Alla Lisyanskaya, Jae-Hoon Kim, Elias Abdo Filho, Tsveta Milenkova, Elizabeth S Lowe, Phil Rowe, Ignace Vergote, Eric Pujade-Lauraine, Jacob Korach, Tomasz Huzarski, Tomasz Byrski, Patricia Pautier, Michael Friedlander, Philipp Harter, Nicoletta Colombo, Sandro Pignata, Giovanni Scambia, Maria Nicoletto, Fiona Nussey, Andrew Clamp, Richard Penson, Amit Oza, Andrés Poveda Velasco, Manuel Rodrigues, Jean-Pierre Lotz, Frédéric Selle, Isabelle Ray-Coquard, Diane Provencher, Aleix Prat Aparicio, Laura Vidal Boixader, Clare Scott, Kenji Tamura, Mayu Yunokawa, Alla Lisyanskaya, Jacques Medioni, Nicolas Pécuchet, Coraline Dubot, Thibault De La Motte Rouge, Marie-Christine Kaminsky, Béatrice Weber, Alain Lortholary, Christine Parkinson, Jonathan Ledermann, Sarah Williams, Susana Banerjee, Jonathan Cosin, James Hoffman, Richard Penson, Marie Plante, Allan Covens, Gabe Sonke, Florence Joly, Anne Floquet, Susana Banerjee, Holger Hirte, Amnon Amit, Tjoung-Won Park-Simon, Koji Matsumoto, Sergei Tjulandin, Jae Hoon Kim, Laurence Gladieff, Roberto Sabbatini, David O'Malley, Patrick Timmins, Daniel Kredentser, Nuria Laínez Milagro, Maria Pilar Barretina Ginesta, Ariadna Tibau Martorell, Alfonso Gómez De Liaño Lista, Belén Ojeda González, Linda Mileshkin, Masaki Mandai, Ingrid Boere, Petronella Ottevanger, Joo-Hyun Nam, Elias Filho, Salima Hamizi, Francesco Cognetti, David Warshal, Elizabeth Dickson-Michelson, Scott Kamelle, Nathalie McKenzie, Gustavo Rodriguez, Deborah Armstrong, Eva Chalas, Paul Celano, Kian Behbakht, Susan Davidson, Stephen Welch, Limor Helpman, Ami Fishman, Ilan Bruchim, Magdalena Sikorska, Anna Słowińska, Wojciech Rogowski, Mariusz Bidziński, Beata Śpiewankiewicz, Antonio Casado Herraez, César Mendiola Fernández, Martina Gropp-Meier, Toshiaki Saito, Kazuhiro Takehara, Takayuki Enomoto, Hidemichi Watari, Chel Hun Choi, Byoung-Gie Kim, Jae Weon Kim, Roberto Hegg, Ignace Vergote
Journal: The Lancet Oncology (2021)
Severe diabetic ketoacidosis
Authors: P. M. Beigelman
Journal: JAMA (1969)

Severe diabetic ketoacidosis is defined by us as a ketoacidotic state with serum bicarbonate decreased to levels of 10 mEq/liter or less. A synonymous term used in the past was "chemical diabetic coma." Although patients are often mentally obtunded and sometimes unconscious, these features are not essential components of the severe ketoacidotic state. Successful management is based on competent monitoring of the clinical and chemical status of the patient. A short-term study of 51 episodes of severe diabetic ketoacidosis in 46 patients admitted to our service, included in this presentation, has emphasized the importance of well-directed management in preventing fatal outcome. Other causes of metabolic acidosis must also be considered. Renal acidosis reflects the failure of the kidney to excrete acid metabolites. Lactic acidosis is due to an excess of lactic acid and usually accompanies tissue anoxia when oxidative metabolism cannot be sustained because of circulatory failure. Another disorder that
Appendix
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ALCOHOLIC EPILEPSY.
Authors: T. D. CROTHERS
Journal: JAMA (1902)

The term "alcoholic epilepsy" is comparatively new in medicine and describes a class of inebriates who have convulsive symptoms resembling epilepsy. Some writers call it a form of delirium tremens and acute alcoholism; others consider it a distinct epilepsy due to the toxic action of alcohol on the brain centers. In some instances the craving for alcohol precedes the paroxysm or epileptic fit like an aura or premonition. Sometimes the convulsion is intensified and increased by alcohol, or in other instances it may be neutralized and the direction of the symptom changed. The sudden maniacal impulse to become narcotized by alcohol, as seen in the dipsomaniac and periodic inebriates, closely resembles epilepsy. A number of cases have been noted where a distinct convulsion preceded the use of spirits and was followed by a continued impulse to drink. When this craving was neutralized by treatment, the convulsion returned. When spirits were
Interfacing between spontaneous breathing and mechanical ventilation affects ventilation-perfusion distributions in experimental bronchoconstriction.
Authors: C Putensen, J Räsänen, F A López
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

The effect of interfacing between spontaneous and mechanical ventilation on ventilation-perfusion (VA/Q) distributions was determined during pressure-support ventilation (PSV) and in the presence and absence of spontaneous breathing during biphasic positive airway pressure (BIPAP) in 10 pigs with methacholine-induced bronchoconstriction. Whereas BIPAP without spontaneous breathing provides full and PSV breath-to-breath synchronized ventilatory support, BIPAP allows unrestricted spontaneous breathing throughout the mechanical cycle. Compared with BIPAP with and without spontaneous breathing, PSV effected an increase in ventilatory rate (p < 0.05) and a higher minute ventilation (VE) (p < 0.05). Spontaneous breathing during BIPAP accounted for 15 +/- 1% of the VE and increased cardiac output (CO) from 4.5 +/- 0.2 to 5.3 +/- 0.2 L/min (p < 0.05), Pao2 from 55 +/- 3 to 80 +/- 4 mm Hg (p < 0.05), and oxygen delivery (DO2) from 442 +/- 39 to 630 +/- 43 ml/min (p < 0.05). PSV did not increase CO, Pao2, and DO2. Spontaneous breathing did not affect oxygen consumption. During BIPAP spontaneous breathing accounted for a 15 +/- 2% decrease (p < 0.05) in blood flow to shunt units and a 16 +/- 2% increase (p < 0.05) in the perfusion of normal VA/Q units. Perfusion of shunt and normal VA/Q units was similar during PSV and BIPAP without spontaneous breathing. Dead space ventilation decreased with spontaneous breathing during BIPAP by 12% compared with PSV (p < 0.05). Dispersion of ventilation distribution was lowest during BIPAP. Uncoupling of spontaneous and mechanical ventilation during BIPAP improved gas exchange by allowing better VA/Q matching during experimental bronchoconstriction.(ABSTRACT TRUNCATED AT 250 WORDS)
Borrelia burgdorferi in the Central Nervous System
Authors: Jorge L. Benach
Journal: JAMA (1992)

<h3>To the Editor.</h3> —Luft et al<sup>1</sup>in their article entitled "Invasion of the Central Nervous System by<i>Borrelia burgdorferi</i>in Acute Disseminated Infection" confirm and extend our experimental and clinical observation on the early invasion of the central nervous system (CNS) by<i>B burgdorferi</i>, the agent of Lyme disease, by using a larger number of cerebrospinal fluid (CSF) specimens and a different detection procedure. Unfortunately, Luft et al misspelled the names of the first three authors of our June 1990 publication beyond recognition (see reference 14 in Luft's article). Considering this, the readership of<i>JAMA</i>interested in this topic may find it useful to have the correct citation of our earlier manuscript: Garcia Monco JC, Fernandez Villar B, Calvo Alen J, Benach JL.<i>Borrelia burgdorferi</i>in the central nervous system: experimental and clinical evidence for early invasion.<i>J Infect Dis</i>. 1990;161:1187-1193.
Surgery
Authors: Alvin M. Cotlar
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal