tbuckley/cabot-search huggingface dataset:
Clinical use of radionuclide bone imaging in a university medical center
Authors: S. D. Fihn
Journal: JAMA (1982)

To assess the diagnostic utility of radionuclide bone imaging, we reviewed all examinations performed during a two-year period in a university medical center. The indication(s) for each bone image and its interpretation were compared by reviewing requisition forms and medical records. Thirty-nine percent of 988 studies demonstrated relevant abnormalities. Yields of pertinent positive findings were greatest in patients with cancers of the breast (40%) and prostate (38%) and lowest in women with uterine cancer (15%), patients with previously normal bone images, and individuals with suspected but unconfirmed malignancy. Incidental findings, unrelated to the indication for imaging, occurred frequently (up to 41% of cases). We did not find a sizable number of negative studies that could readily be labeled as unnecessary, suggesting that bone imaging is generally a useful procedure as applied by physicians in this setting. (<i>JAMA</i>1982;248:439-442)
Intestinal Metabolism
Authors: John W. Porteous
Journal: Environmental Health Perspectives (1979)

The anatomy of the intestine is outlined. The kinetics of cell proliferation, differentiation, and migration in intestinal epithelium are described. The distribution of cell types between the proliferation and differentiation compartments of the epithelium is summarized. Seven preparations of intestine in current use for metabolic studies are listed. An outline review is presented of recent results on glucose, amino acid and ketone body metabolism obtained with three of these preparations: the ligature-isolated loop of intestine in vivo; the vascularly and luminally perfused intestine in vitro; and suspensions of respiring intestinal epithelial cells in vitro. Reasons are given for thinking that these experimental systems are among the most useful currently available for metabolic studies, perhaps especially in the investigation of the metabolic fate of potentially toxic materials to which animal species may be exposed.
European Perspectives
Journal: Circulation (2010)

is a neuroradiologist, and his sister-in-law, Gesine Behnike, is a cardiologist.In fact, all his close relatives are involved in medicine, apart from his wife, Sabine, who is an architect. "Every Case [of Congenital Heart Disease] Is Different"It was against this medical background that Professor Kuehne took what was at the time a "considered" decision not to study medicine, and he spent the first 2 years of university life studying electrical engineering in Berlin.He says, "I then saw that was not the right subject for me, and I changed to medicine."He went on to complete his medical training at universities in Kiel, Germany, Paris, France, and Berlin.His thesis, "In vitro and in vivo evaluation of magnetic resonance imaging flow analysis in patients with congenital heart disease," shaped his career as a cardiac imaging specialist with a special interest in congenital heart disease.In particular, the combination of "imaging, intervention, and surgery in the complex settings of congenital heart diseases" inspired him to go into cardiology.Professor Kuehne believes there is more variety in the field of congenital heart disease than in any other medical
Cost of Primary Care Plans
Journal: JAMA (1981)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
July 1977, Vol. 59, No. 1
Journal: JNCI Journal of the National Cancer Institute (1977)

July 1977, Vol. 59, No. 1 Get access JNCI: Journal of the National Cancer Institute, Volume 59, Issue 3, September 1977, Pages 1035–1038, https://doi.org/10.1093/jnci/59.3.1035-d Published: 01 September 1977
A Multi-Center, Open-Label Study To Evaluate the Safety and Efficacy of Pentostatin, Cytoxan, and Rituxan (PCR) in the Treatment of Previously Untreated or Treated, Stage II, III or IV CLL.
Authors: Raul R. Mena, Robert Robles, Michael Auerbach, Mehdi M. Moezi, David Headley
Journal: Blood (2006)
Segmentation And Segmental Differentiation In The Development Of The Central Nervous Systems Of Leeches And Flies
Authors: M Levine
Journal: Annual Review of Neuroscience (1990)

The brain's default mode network consists of discrete, bilateral and symmetrical cortical areas, in the medial and lateral parietal, medial prefrontal, and medial and lateral temporal cortices of the human, nonhuman primate, cat, and rodent brains. Its ...Read More
<i>Announcement:</i> Drowsy Driving Prevention Week — November 6–13, 2016
Journal: MMWR Morbidity and Mortality Weekly Report (2016)

Drowsy Driving Prevention Week, the National Sleep Foundation's annual campaign to educate the public about the hazards of driving while sleepy, will be observed November 6-13, 2016. A report released by the AAA Foundation for Traffic Safety in 2014 concluded that drowsy drivers were involved in an estimated 21% of fatal crashes, based on a nationally representative sample of motor vehicle crashes during 2009-2013 (1).
Colon Polyps and Cancer
Authors: J. H. Bond
Journal: Endoscopy (2003)

A large number of studies published last year in peer-reviewed medical journals help to better define the advantages and limitations of the different options for colorectal cancer screening. Direct colonoscopy screening appears to have the greatest potential to markedly reduce both the incidence and mortality of colorectal cancer, but many obstacles limiting its widespread use in the general at-risk population still exist, and many questions remain incompletely answered. Recent studies stress the fact that finding and resecting advanced adenomatous polyps, and thereby preventing cancer, is becoming a primary objective of screening programs. Several papers also show the potential of emerging new methods of screening for specific markers in stool and for imaging the colon with computed-tomographic colonography (virtual colonoscopy). Other important publications highlighted in this review deal with the diagnosis of colorectal neoplasia, familial colorectal cancer, colorectal polyps and the adenoma-carcinoma sequence, and new and novel methods of improving the efficiency and safety of colonoscopic polypectomy.
Progress in nursing home care
Authors: F. M. Foote
Journal: JAMA (1967)

By classifying nursing homes in five categories by services and resources available, and by tying payment for state patients to rates set in relation to this classification, one state has greatly improved the quality of care provided. Nursing, dietary, and medical services have been upgraded, and many more homes are providing other rehabilitative and therapeutic services. Now, after five years, there are more than five times as many beds in homes in the highest class and only one-fifth as many beds in the lowest category.
BOOK REVIEWS
Authors: W. E. FOGLER
Journal: JNCI Journal of the National Cancer Institute (1989)

BOOK REVIEWS Get access Immunity to Cancer. II. Progress in Clinical and Biological Research. Volume 288. Malcolm S. Mitchell, ed. New York: Alan R. Liss, Inc., 1989, 520 pp. $90. WILLIAM E. FOGLER WILLIAM E. FOGLER Investigational Drug Branch, Cancer Therapy Evaluation Program, Division of Cancer Treatment, National Cancer InstituteExecutive Plaza North, Rm. 715, Bethesda, MD 20892 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 81, Issue 19, 4 October 1989, Pages 1506–1507, https://doi.org/10.1093/jnci/81.19.1506 Published: 04 October 1989
IMpower150: An exploratory analysis of efficacy outcomes in patients with EGFR mutations
Authors: T.S.K. Mok, M.A. Socinski, M. Reck, R.M. Jotte, D.W.-T. Lim, F. Cappuzzo, F.J. Orlandi, D. Stroyakovskiy, N. Nogami, D. Rodríguez-Abreu, D. Moro-Siblot, C.A. Thomas, F. Barlesi, G. Finley, A. Lee, G. Shankar, W. Yu, M. Kowanetz, W. Lin, M. Nishio
Journal: Annals of Oncology (2018)
Hailey
Authors: William B. Weeks
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A phase 2, open-label study of pan-genotype regimen of SH229 plus daclatasvir in Chinese patients with chronic hepatitis C virus infection
Authors: Rui Hua, Fei Kong, Guangming Li, Yuexin Zhang, Xiaofeng Wen, Qingfang Xiong, Jiayu Chen, Chenxin Meng, Hong Ma, Youwen Tan, Yan Huang, Yongfang Jiang, Yujuan Guan, Xiaorong Mao, Jiefei Wang, Yongning Xin, Hainv Gao, Bin Xu, Cheng Li, Xian Zhang, Zhiqiang Wang, Yanhua Ding, Junqi Niu
Journal: Journal of Hepatology (2020)
Comparison between diazepam and sodium thiopental during DC countershock
Authors: J. J. Muenster
Journal: JAMA (1967)

SYNCHRONIZED, external direct-current (DC) countershock has proved to be a valuable tool for the correction of cardiac arrhythmias since its introduction by Lown and his co-workers in 1962.<sup>1,2</sup>Sodium thiopental has been used as the anesthetic agent for this procedure in most clinical studies.<sup>3-5</sup>Recently, Nutter and Massumi<sup>6</sup>reported using diazepam intravenously for the brief period of analgesia-amnesia necessary for DC countershock. In this laboratory 108 patients have had elective DC countershock, in the period August 1962 to December 1965, under sodium thiopental anesthesia. Analysis of continuous electrocardiograms made before, during, and after the DC countershock disclosed the occurrence of premature ventricular contractions in many patients. In each instance when this additional arrhythmia occurred, it appeared after induction of anesthesia but before the DC countershock was given. The occurrence of this additional arrhythmia was disturbingly frequent. These premature ventricular complexes often persisted for several minutes after the
Hepatitis B surface antigen and antibody in asymptomatic blood donors
Authors: J. C. Sinclair
Journal: JAMA (1976)

Seventy-two volunteer blood donors who had hepatitis B surface antibody (anti-HB<sub>s</sub>) were studied and compared with 115 carriers of hepatitis B surface antigen (HB<sub>s</sub>Ag). Anti-HB<sub>s</sub>-positive donors gave a history of greater possible exposure to hepatitis B virus, there was a lower male-female ratio, and they had a much lower frequency of abnormal hepatic function test results. Those who were positive by counterimmunoelectrophoresis (CIEP), which indicated a high titer of antibody (&gt;1:2,000 as measured by passive hemagglutination assay [PHA]), also had an ethnic origin similar to that of the donor panel, ie, predominantly Canadian and northern European. The HB<sub>s</sub>Ag carriers, on the other hand, had a high frequency of origin from Mediterranean and Far Eastern countries. Low-antibody-titer (positive PHA but negative CIEP) donors had ethnic origins that more closely approximated those of HB<sub>s</sub>Ag carriers. (<i>JAMA</i>235:1014-1017, 1976)
Dysphagia in parkinsonism
Authors: E. D. Palmer
Journal: JAMA (1974)

WHEN the patient with parkinsonism develops dysphagia, it is almost always hypopharyngeal dysphagia. Fortunately, this is not a common problem in parkinsonism, for the tracheopulmonary consequences are potentially disastrous, and the patient's distress is almost unbearable. For the individual patient, efforts to pin down the cause of the dysphagia have often left the clinician uncertain. The reason is that cinefluoroscopy, ordinarily an excellent method for investigating hypopharyngeal dysphagia, proves strangely difficult to interpret when there is parkinsonism. "Neuromuscular incoordination" is about as far as the interpretation can go. When the fuzziness of cinefluoroscopy is replaced by the sharpness and clarity of the 105-mm 6 or 12/sec photofluoroscopic technique, however, it becomes clear that the whole problem is caused simply by classical cricopharyngeal achalasia. In this form of hypopharyngeal neuromuscular incoordination, the cricopharyngeus muscle either does not open quickly enough as the bolus descends through the pharynx or it closes again
Correction
Journal: BMJ (1954)

ANY QUESTIONS?MEDICALJou suggested that serum hepatitis is the more severe.The chances of cirrhosis in a previously healthy subject are probably in the region of 0.5-1%, but this figure may be higher after subsequent attacks.Oil at WorkQ.-I have a patient whose normal work is that of machine-tool setter, but he has developed what appears to be a sensitivity to the oil used.lIe was put on another job
Archiv für Kreislaufforschung, Darmstadt
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SUICIDE IN THE UNITED STATES.
Journal: JAMA (1903)

The Journalhas previously noticed the communications published by Mr. Frederick Hoffman of the Prudential Life Insurance Company in the<i>Spectator</i>on the subject of suicides in the United States. In that journal, August 27, he gives a review of the suicide records of fifty of the principal cities in this country for 1902, with a comparison with the ten years preceding—1892 to 1901, inclusive. The record shows an increase in the rate during the year in twenty-eight towns, a decrease in twenty-one, and in one small town only was the ratio unchanged. The total gives the decided increase of from only twelve in 1890 to over seventeen per 100,000 of the population. Another table shows that the suicide rate has increased during the past thirteen years from twelve per 100,000 in 1890 to 1902. The gradual progressive increase would indicate that a still higher ratio may be reached in
Development of 19 F NMR for Measurement of [Ca 2+ ] i and [Pb 2+ ] i in Cultured Osteoblastic Bone Cells
Authors: Francis A. X. Schanne, Terry L. Dowd, Raj K. Gupta, John F. Rosen
Journal: Environmental Health Perspectives (1990)

Lead (Pb) has been shown to perturb cellular calcium (Ca) homeostasis, altering sizes and flux rates of cellular pools of exchangeable Ca and impairing Ca-mediated cell processes.To date, however, a direct effect of Pb on intracellular-free Ca2+ has not yet been demonstrated.Heavy metals bind to the commonly used fluorescent Ca ion indicators with greater afflnity than does Ca and thereby interfere with the expected Ca-dependent fluorescence.In this study, the fluorinated Ca ion indicator, 1,2-bis(2-amino-5-fluorophenoxy)ethane N,N,N',N'-tetraacetic acid (5F-BAPTA), and "F NMR were used to measure the free intracellular Ca ion concentration ([Ca2`],) in the rat osteoblastic bone cell line, ROS 17/2.8.Both Pb and Ca bind to 5F-BAPTA with high affinity, but the Pb-5F-BAPTA comple produces a "9F NMR signal at a chemical shift distinct from 5F-BAPTA and the Ca-5F-BAPTA complex.The apparent dissociation constants for Pb-5F-BAPTA and Ca-5F-BAPTA are 2 x 10-10 M and 5 x 10-7 M, respectively, at 30'C, pH 7.1, and Mg2+ (0.5 mM).Thus, this methodology allows for the simultaneous identification and quantification of free Pb and free Ca ion concentrations.Determinations of [Ca2+1J were based on "9F NMR measurements of 5F-BAPTA-loaded ROS 17/2.8 osteoblastic bone cells that were attached to collagen-coated mictocarrier beads.Cells were continuously superfused with freshly oxygen- ated medium at 30'C.Under these conditions, the [Ca2+J1 of ROS 17/2.8 cells was observed to be 128 ± 14 nM.Treatment with parathyroid hormone produced a nearly 2-fold increase in [Ca2+J within the first half hour, with a subsequent return to pretreatment levels.This work demon- strates the usefubness of 5F-BAPTA and "9F NMR for measuring [Ca2+], in cells in monolayer culture in response to physiologic agents, and it indicates its potential for studies of the toxic effect of heavy metals on cellular Ca homeostasis.
Research in Bariatric Surgery
Authors: Roman Schumann
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SYPHILITIC AORTITIS AND ANEURISM.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Physicians and Statistics
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The BCG controversy. A methodological and statistical reappraisal
Authors: J. D. Clemens
Journal: JAMA (1983)

Because of the conflicting results of eight major controlled trials, BCG vaccination against tuberculosis remains controversial despite more than 50 years of use. Suspecting a methodological source for the controversy, we reviewed the scientific and statistical quality of each trial. The analysis showed that (1) although biased allocation of the vaccine appeared an unlikely explanation for the disparate results, adequate demonstration of unbiased detection of tuberculosis was available only for the three trials reporting 75% or greater protective efficacy; and (2) in most trials reporting low efficacy, the results had wide confidence intervals that could not exclude high efficacy, but the trials reporting high efficacy all had narrow confidence intervals that excluded low efficacy. Because the trials with the best methodological quality and greatest statistical precision reported high efficacy, the evidence suggests that BCG can confer a high degree of protection against tuberculosis and that bias or inadequate statistical power may have contributed to the conflicting data. (<i>JAMA</i>1983;249:2362-2369)