tbuckley/cabot-search huggingface dataset:
Aging does not reduce the hepatocyte proliferative response of mice to the primary mitogen TCPOBOP
Authors: Giovanna M. Ledda-Columbano, Monica Pibiri, Costanza Cossu, Francesca Molotzu, Joseph Locker, Amedeo Columbano
Journal: Hepatology (2004)

It has been shown that the magnitude of DNA synthesis and the time at which maximal DNA synthesis occurs after two-thirds partial hepatectomy (PH) is greatly reduced in the liver of aged rodents compared to young animals. This reduction could represent an intrinsic defect in proliferation or a more specialized change in the response to PH. We therefore evaluated the proliferative capacity of hepatocytes in aged animals, following treatment with primary liver mitogens. We show that treatment of 12-month-old CD-1 mice with the hepatomitogen 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP) caused an increase in hepatocyte proliferation similar to that seen in young (8-week-old) mice. The labeling index was 82% in the livers of aged mice versus 76% in young animals. Histological observation demonstrated that the number of hepatocytes entering mitoses was similar in both groups; the mitotic indices were 2.5 per thousand and 2.7 per thousand, respectively. Additional experiments showed that the timing of DNA synthesis and M phase were nearly identical in both aged and young mice. Stimulation of hepatocyte DNA synthesis was associated with increased expression of several cell cycle-associated proteins (cyclin D1, cyclin A, cyclin B1, E2F, pRb, and p107); all were comparable in aged mice and young mice. TCPOBOP treatment also increased expression of the Forkhead Box transcription factor m1b (Foxm 1b) to a similar degree in both groups. In conclusion, hepatocytes retain their proliferative capacity in old age despite impaired liver regeneration. These findings suggest that therapeutic use of mitogens would alleviate the reduction in hepatocyte proliferation observed in the elderly. (Hepatology 2000;40:981-988).
THE EARLY DIAGNOSIS OF CARCINOMA OF THE STOMACH, WITH THE BACTERIOLOGY OF THE STOMACH CONTENTS.
Authors: FENTON B. TURCK
Journal: JAMA (1895)

The product formed in the growth of carcinoma of the stomach—whatever it may be—seems early to alter the gastric, secretory and motor functions. The mucous membrane is markedly affected by this product, so that even before the complete suppression of HCl and other secretory changes have occurred a soil is rendered fertile for the growth of microörganisms, especially the bacterium lacticus and in many cases investigated, seemed the predominating microörganisms. In the Chicago Post-Graduate Medical School, clinic (on diseases of the stomach and intestines), the Cook County Hospital clinic and in private practice, it is my routine custom to make microscopic slides in almost every case stained for the detection of bacteria. In selected cases of various gastric diseases, pure cultures are made to determine as far as possible the predominant germs. The various cultures are secured from the mucous membrane, by using a revolving sponge introduced into the empty
Lead poisoning due to hai ge fen. The porphyrin content of individual erythrocytes
Authors: S. B. Markowitz
Journal: JAMA (1994)

A 45-year-old Korean man developed abdominal colic, muscle pain, and fatigue. Following a 3-week hospitalization, acute intermittent porphyria was diagnosed based on the symptoms and a high level of urinary δ-aminolevulinic acid (378 μmol/L [4.95 mg/dL]). However, discovery of an elevated blood lead level (3.7 μmol/L [76 μg/dL]) subsequently led to the correct diagnosis. No occupational source of lead exposure was identified. The patient reported ingesting a Chinese herbal preparation for 4 weeks prior to becoming ill. A public health investigation revealed that the source of lead exposure was<i>hai ge fen</i>(clamshell powder), one of the 36 ingredients of the Chinese herbal medicine. We used fluorescence image—based cytometry to determine the frequency distribution of the zinc protoporphyrin content in circulating red blood cells and found that 70% of the patient's cells contained elevated levels of zinc protoporphyrin, consistent with the duration of lead exposure and effect of lead on heme synthesis. Analysis of zinc protoporphyrin content in circulating red blood cell distributions may be useful in the diagnosis, therapy, and kinetic modeling of lead poisoning. Environmental lead poisoning is best addressed through the close collaboration of clinicians, public health specialists, and laboratory scientists. (<i>JAMA</i>. 1994;271:932-934)
Medical Tests
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction
Journal: BMJ (1966)

We publish below a selection of questions and answers of general interest.Hazards from Aminofluoride Flux Q.-Is there any danger in inhaling the fumes given off when soldering aluminium with Kynal flux ?Are there any toxic effects from handling the flux, and does it affect the skin?A.-Kynal is an organic aminofluoride flux.McCann' studied the possible health hazards arising from the use of such fluxes.Health and safety problems in soldering and brazing and the preventive measures to be taken are outlined in detail in an Institute of Welding publication.2The active constituents of fluxes such as Kynal are believed to be ammonium fluoroborate, aminoethylethanolamine, and zinc oxide.The fumes evolved from soldering may contain ammonia, boric acid, hydrogen
A SUMMARY AND ANALYSIS OF RECENT OBSERVATIONS AND THEORIES AS TO THE PROCESSES OF INFECTION AND PROTECTION IN THE ORGANISM
Authors: H. W. Armit
Journal: BMJ (1902)

THE immune body has been spoken of as amboceptor because it anchors the complement and the red cell.Its action is merely that of a coupler, but it is specific in a sense, inasmuch as only a suitable receptor can be made use of by a single type of complement.'lhe specificity depends further ,on the presence of a specific binding group, which anchors it to the red cell.The amboceptor is produced specifically by the introduction of the blood cells of a species into the organ- ism of another, or it may exist normally in the blood of certain species.Now it has been shown that antibodies are nothing more than receptors cast off from the cells, and as the amboceptor is a side chain produced by the red corpuscle, it must be accepted that what was previously spoken of as a receptor of the blood cell, after being cast off, becomes an amboceptor.This applies to bacteriolysin as well as to haemolysin.Bel-
An Essay on the Chemical, Botanical, Physical, and Parturient Properties of the Secale Cornutum
Journal: BMJ (1841)

ROYAL MEDICAL AND,CHIRURGIC&L SOCIETY.farther, and must rest satisfied with having briefly indicated the general fact of the high ratio of mor- tality of insanity, and especially among pauper patients treated in, or perhaps we should say, re- ceived into, certain private asylums.We purpose, upon some future occasion, to resume the subject, and shall then endeavour to point out other cir- cumstances in the general condition and mode of management of the insarne, which require careful investigation.
This Week in &lt;EMPH&gt;JAMA&lt;/EMPH&gt;
Journal: JAMA (2005)

Susan M. Chang, MD; Ian F. Parney, MD, PhD; Wei Huang, MS; Frederick A. Anderson, PhD; Anthony L. Asher, MD; Mark Bernstein, MD; Kevin O. Lillehei, MD; Henry Brem, MD; Mitchel S. Berger, MD; Edward R. Laws, MD; for the Glioma Outcomes Project Investigators
Refresher Course in Radiation Therapy and Physics
Journal: JNCI Journal of the National Cancer Institute (1974)

Journal Article Refresher Course in Radiation Therapy and Physics Get access JNCI: Journal of the National Cancer Institute, Volume 52, Issue 3, March 1974, Page 1026, https://doi.org/10.1093/jnci/52.3.1026 Published: 01 March 1974
Brief Report: Foodborne Botulism From Home-Prepared Fermented Tofu—California, 2006
Journal: JAMA (2007)

cides or of undetermined intent might have been unintentional and therefore not analyzed in this study.The extent of this error is not known.Effective response to increasing fatal drug overdoses requires strengthening regulatory measures to reduce unsafe use of drugs, increasing physician awareness regarding appropriate pharmacologic treatment of pain and psychiatric problems, supporting best practices for treating drug dependence, and potentially modifying prescription drugs to reduce their potential for abuse.State agencies that manage prescription-monitoring programs should use such systems to proactively identify (1) patients who abuse drugs and fill multiple prescriptions from different health-care providers and (2) providers whose prescribing practices are outside the standards of appropriate medical care.Both federal and state prevention measures should be evaluated periodically to determine their effectiveness.
Outlines Of Early Development for Obstetric Students.
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Treatment of metastatic hypernephroma
Authors: R. W. Talley
Journal: JAMA (1969)

Metastatic hypernephroma has been notoriously resistant to control by conventional methods of therapy. A review of 72 patients treated by various methods revealed that patients in whom metastases recurred 18 months or longer after initial diagnosis had a median survival of almost 15 months; those patients in whom metastases recurred less than 18 months after diagnosis had a median survival of about 8 months. Treatment with radiation therapy frequently palliated symptoms produced by local metastases, but did not alter survival patterns. Excision of single metastatic deposits was associated with increased survival in three of four patients with pulmonary metastases and in two of three patients with thyroid metastases. Systemic chemotherapy was generally unrewarding. However, two excellent objective regressions were observed in 16 patients treated with progestational agents.
Breast Cancer Probabilities
Journal: JAMA (1977)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An Address Delivered at the Opening of the Section of Public Medicine
Authors: J. B. Russell
Journal: BMJ (1876)

The flavoprotein inhibitor, diphenyleneiodonium (DPI), inhibits the action of glyceryl trinitrate (GTN) and the d-enantiomer of isoidide dinitrate (IIDN), but not the l-enantiomer (l-IIDN), in isolated rat aorta via inhibition of the bioactivation of these prodrugs. Paradoxically, a vascular NAD(P)H oxidase, which also is inhibited by DPI, has been proposed to generate superoxide that quenches nitric oxide (NO) produced during GTN biotransformation, and increased oxidase levels are proposed to contribute to the phenomenon of organic nitrate tolerance. We examined the effect of DPI on isolated rat aorta using an in vivo model of organic nitrate tolerance. The EC<sub>50</sub> values for GTN-,d-IIDN-, and l-IIDN-induced relaxation of aorta from GTN-tolerant rats were increased 4.5- to 7.5-fold. Treatment of blood vessels with DPI (0.3 μM) increased the EC<sub>50</sub> values for GTN and d-IIDN by the same magnitude in control and tolerant aortae, a result that would not be predicted if DPI and GTN tolerance affected common targets. The expression of NADPH-cytochrome P450 reductase (CPR) during in vivo tolerance was assessed by NADPH-dependent cytochrome <i>c</i> reductase activity of aortic microsomes, immunoblotting, and Northern analysis. By all three determinants, CPR expression was unchanged in aorta from GTN-tolerant rats. Superoxide dismutase-inhibitable NADPH-dependent cytochrome <i>c</i> reductase activity (a measure of superoxide generation) of tolerant rat aortic microsomes was not different from that of controls. Superoxide dismutase-inhibitable NADH-dependent cytochrome <i>c</i> reductase activity was detected only in microsomes from tolerant animals. DPI caused a modest increase in the sensitivity for relaxation by the NO donor DEA NONOate to an equal extent in tolerant and nontolerant tissues, whereas the superoxide scavenger, 4,5-dihydroxy-1,3-benzene disulfonic acid (Tiron), had no effect on the sensitivity for relaxation by GTN. These results would not be expected if tolerance-induced increases in superoxide were a causative factor for the reduced relaxation response in tolerance. We conclude that neither reduced flavoprotein-dependent metabolic activation of organic nitrates, such as that mediated by CPR, nor increased superoxide due to increased NAD(P)H oxidase activity can account for the development of in vivo tolerance to GTN.
Vegetable Dust and Airway Disease: Inflammatory Mechanisms
Authors: J. Allen D. Cooper, Marion G. Buck, J. Bernard L. Gee
Journal: Environmental Health Perspectives (1986)

Exposure to cotton or grain dust causes an obstructive bronchitis in certain subjects, mechanisms of which are poorly understood. A difficulty encountered in discerning mechanisms of this airway disease is the lack of knowledge of the active components of these dusts. Clinical features suggest common but not exact mechanisms of the airway disease associated with these vegetable dusts. Human and animal studies show evidence of acellular and cellular inflammatory mechanisms of the bronchoconstriction and inflammation associated with these disorders. Potential cellular sources include alveolar macrophages, polymorphonuclear leukocytes, mast cells, basophils, eosinophils and lymphocytes. Acellular origins include the complement and humoral antibody systems, both of which have been implicated, although their pathogenic role in grain or cotton dust disorders is uncertain. In this review we critically address potential inflammatory mechanisms of airway alterations resulting from cotton or grain dust exposure. General mechanisms of bronchoconstriction are first presented, then specific studies dealing with either of the two dusts are discussed. We believe this area of research may be fruitful in dissecting mechanisms of bronchoconstriction and airway inflammation, especially as more human studies are undertaken.
Correction
Journal: BMJ (1948)

the oval window, or the vestibular nerve may be cut.Tetra- ethyl-ammonium chloride is used to reduce high blood pressure but, so far as the writer knows, has no place in the diagnosis and treatment of Meniere's syndrome.Sprue and Malignant Disease Q.-Does sprue predispose to malignant disease ?If a patient with sprue developed a carcinoma of the bowel laparotomy could not be undertaken because of the weakness and emaciation, and death might be wrongly attributed to the sprue.A.-There is no reliable evidence that sprue predisposes to malignant disease.With adequate treatment most cases of sprue respond rapidly and satisfactorily enough to permit exploratory operation where indicated.
BELGIUM
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Beclovent
Journal: JAMA (1976)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Care of the mentally handicapped.
Authors: M Chadd, P Elwood, S Gray
Journal: BMJ (1972)

on the need for concentrates of the pro- thrombin complex, particularly for treatment of liver disease, prompts us to report our experience in this field.We are just completing a pilot study on the feasibility of preparing such a concentrate at a regional blood transfusion centre.We chose the method of Bruning and Loeliger,' with slight modifications, for the following reasons: (1) supernatant ACD on 19 August
DYNAMIC ILEUS.
Authors: JOHN C. MUNRO
Journal: JAMA (1907)

The term ileus signifies not a disease, not a symptom, but a group of symptoms associated with many and widely varying causes. These symptoms are abdominal pain, nausea or vomiting, distension and intestinal obstruction. The relative importance of each symptom varies in the individual case, while collectively they may indicate a condition that varies between harmless postoperative discomfort and a rapidly fatal obstruction. The simplest classification of ileus includes, on the one hand, the mechanical type, where the intestinal obstruction is due to some form of physical interference with the intestinal current, and, on the other hand, the dynamic ileus, in which the obstructions are secondary to some interference with the neuromuscular mechanism of the gut. In the mechanical class we should include stricture, tumors, invaginations, bands, etc. In the dynamic class would fall those cases due to peritonitis, trauma, sepsis, reflex irritations, spinal lesions, etc. But even in the
Fundamental Principles of the Pathogenesis of General Infections.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal