tbuckley/cabot-search huggingface dataset:
Diagnostic and therapeutic technology assessment. Coronary rehabilitation services
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The physically disabled physician
Authors: S. F. Wainapel
Journal: JAMA (1987)

This article reviews the available literature on physically disabled physicians and discusses the attitudinal, environmental, and political barriers they may encounter. Information on 215 physicians and 92 medical students with a wide range of disabilities was analyzed. Currently available personal and technological resources are outlined and special issues pertaining to medical education are highlighted. Greater awareness and acceptance by medical peers are essential for professional success. (<i>JAMA</i>1987;257:2935-2938)
Issues and Current Applications of Interspecies Extrapolation of Carcinogenic Potency as a Component of Risk Assessment
Authors: Willard J. Visek
Journal: Environmental Health Perspectives (1988)

The Life Sciences Research Office (LSRO) of the Federation of American Societies for Experimental Biology (FASEB) is conducting this symposium under contract with the Center for Food Safety and Applied Nutrition (CFSAN) of the Food and Drug Administration (FDA). The FDA has requested information on the strengths and weaknesses of current interspecies extrapolation methods using metabolic and pharmacokinetic data, identity of data for these methods, bases for choice of extrapolation method and selection of data base, validity and uniformity of interspecies extrapolation from target organ data, and nature and completeness of supporting data. Definitions and basic concepts of dose scaling are addressed and questions regarding appropriate units of measurement (e.g., mg/kg body weight, mg/m3 respired air, mg/m2 surface area) are raised. The use of DNA damage as a marker or end point upon which to scale carcinogenic potency is considered. Genotoxic mechanisms of carcinogenesis are emphasized because the roles of DNA adducts and DNA repair processes in initiation and promotion are much better defined than the mechanism for nongenotoxic carcinogenesis. The problems encountered in evaluating the human carcinogenicity of trichloroethylene are reviewed. The broad objectives of the symposium are discussed and the development of a structured format for the presentation of invited papers is presented.
Phenformin Acidosis
Authors: Louis Freedman
Journal: JAMA (1964)

<h3>To the Editor:—</h3> Tranquada et al (<i>JAMA</i><b>184</b>:37 [April 6] 1963) reported a causal relationship between phenformin hydrochloride and irreversible lactic acidosis in three elderly diabetics with histories of azotemic renal disease. This conclusion was based on blood phenformin values reportedly obtained by a chemical method developed by Tranquada and Bender. Through the courtesy of Dr. Tranquada we were privileged to obtain the protocol of his as yet unpublished procedure. After an exhaustive study made in this laboratory, we find the procedure to be invalid for the following reasons. Spectrophotometric measurements at 233mμ, on which the procedure was based in part, are inapplicable, since other components such as creatinine absorb in this region. The procedure involves dialysis of serum in order to obtain phenformin. Creatinine and other compounds are also obtained, thus making this step invalid. We applied the proposed method to sera of four azotemic
Lecture on the Antagonism between the Actions of Active Substances
Authors: T. R. Fraser
Journal: BMJ (1872)

MR. PRESIDENT AND GENTLEMEN,-When I was honoured by the request to bring under your notice some subjects bearing upon pharmacology, I found myself placed in the difficult position of having too many good things to choose from.Within my reach were the fruits- seldom altogether ripe, but without exception temptingly attractive-of numerous investigations, conducted both in this country and abroad, in the field of pharmacological research.At my disposal, also, were the methods by which these fruits had been cultivated-the refinements of experimentation, and the mechanical appliances by whose aid, within recent years, results of surpassing beauty and interest have been ob- tained, and much progress has been made in the establishment of a sound basis for therapeutics.The consideration of either of these sub- jects, however, would have required much more time than could be found within the limits of two lectures.It was for this reason that I selected two subjects that admit of briefer discussion, while at the same time they possess a sufficiently independent interest to allow of their being treated apart from the general subject in which they are included.Definition of Anitz,ajonism.-The connection between the chemical properties and the physiological action of active substances occupies a position on the border-land of pharmacology, for it is placed between pharmacology and one of the sciences most intimately related to it.The subject which I propose this evening to bring before you is placed, on the contrary, in the centre of this region, seeing that it is chiefly
Fluoridation of water supply
Authors: E. H. Smith
Journal: JAMA (1974)

IT IS a professional truism that prevention is preferable to treatment for any disease. The simple expedient of fluoridating communal water supplies offers effective prevention of the most common disease in our nation-dental decay, which affects over 95% of our population. Water fluoridation, the least expensive dental public health measure for the control of caries, demonstrates its greatest efficacy for children, who may realize a new dental decay reduction of 60% to 70%. Adults also receive considerable benefit, though not to the same dramatic extent. At this time when the capabilities of health care providers are strained to the utmost to meet the demands placed on them, and more and more of the population view health care as the right of every citizen, it is absolutely essential that every proven public health measure be implemented. <h3>Value Established Beyond Question</h3> Extensive research, conducted over a period of 35 years, has established
Continuous Quality Improvement
Authors: Stephen B. Kritchevsky
Journal: JAMA (1991)

There has been a growing interest by health care leaders in the continuous quality improvement method of quality management. This method uses measurements of quality "indicators" to initiate and drive organizational changes in a never-ending cycle of continuous improvement. Many discussions of the continuous quality improvement method have emphasized the organizational and attitudinal changes necessary to fully implement the model while deemphasizing the uses of measures of quality to guide improvement. In this article, we emphasize the concepts behind the measurement of quality that underlie the continuous quality improvement model and give examples of how these concepts can be immediately applied to guide improvement in the quality of physician care. (<i>JAMA</i>. 1991;266:1817-1823)
Endoscopic Ultrasonography
Authors: P. Fusaroli, G. Caletti
Journal: Endoscopy (2003)

This review again uses a practical arrangement of the topics of endoscopic ultrasonography (EUS) into clinical categories rather than single diseases. The clinical categories include established indications, such as staging of gastrointestinal tract cancers, differential diagnosis of submucosal tumors, evaluation of solid and cystic pancreatic masses, detection of lymph nodes, evaluation of the biliary tree, and fine-needle aspiration (FNA). In addition to established indications, surgical and investigational techniques are presented, such as fine-needle therapeutic procedures and methods of studying portal hypertension and hepatic, abdominal, and retroperitoneal masses. This year, the new techniques and instruments presented have not included new probes or endoscopes, as these have already gained wide application in published papers and clinical practice. However, new techniques capable of facilitating the use of existing equipment are discussed, such as computer-aided EUS image analysis. Finally, some fascinating studies investigated outcomes with EUS and the cost-effectiveness of the method - stimulating both endosonographers and non-endosonographers to think about current practices and ways of improving them.
What's new this month in BMJ Journals
Authors: Harvey Marcovitch
Journal: BMJ (2005)

A survey of 156 UK children aged 2 months to 3 years admitted to hospital with encephalitis or fever and convulsions (almost all cases over a three year period) has shown that human herpesviruses 6 and 7 caused 17% of cases. These viruses have been associated with the benign infection exanthem subitum (roseola infantum) and only occasionally with convulsions or encephalitis. Investigators from the Royal Free and University College Medical School, London, recommend searching for evidence of human herpesvirus in all children with acute neurological disease, especially when there is a temporal relation with immunisation, where a mistaken claim of an adverse reaction is easily made. Arch Dis Child 2005; 90: 619–23 [OpenUrl][1][Abstract/FREE Full Text][2] [1]: {openurl}?query=rft.jtitle%253DArchives%2Bof%2BDisease%2Bin%2BChildhood%26rft.stitle%253DArch.%2BDis.%2BChild.%26rft.issn%253D0003-9888%26rft.aulast%253DWard%26rft.auinit1%253DK%2BN%26rft.volume%253D90%26rft.issue%253D6%26rft.spage%253D619%26rft.epage%253D623%26rft.atitle%253DHuman%2Bherpesviruses-6%2Band%2B-7%2Beach%2Bcause%2Bsignificant%2Bneurological%2Bmorbidity%2Bin%2BBritain%2Band%2BIreland%26rft_id%253Dinfo%253Adoi%252F10.1136%252Fadc.2004.062216%26rft_id%253Dinfo%253Apmid%252F15908629%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/ijlink?linkType=ABST&journalCode=archdischild&resid=90/6/619&atom=%2Fbmj%2F331%2F7509%2F133.atom
A real-world study of treating advanced liver cirrhosis due to chronic HCV infection genotype 1b with sofosbuvir+ ledipasvir with or without ribavirin: results from a cohort of 349 patients
Authors: Carmen Monica Preda, Liana Gheorghe, Doina Istratescu, Mircea Mănuc, Corina Pop, Grigore Andreea, Speranta Iacob, Teodora Manuc, Letiţia Ţugui, Cristian Tieranu, Mircea Mihai Diculescu, Elena Laura Iliescu
Journal: Journal of Hepatology (2020)
Errors in Number at Risk and Author Email Address
Authors: Maria Chiara Sighinolfi, Baris Turkbey
Journal: JAMA Oncology (2018)

Baohui Han, MD; Kai Li, MD; Qiming Wang, MD; Li Zhang, MD; Jianhua Shi, MD; Zhehai Wang, MD; Ying Cheng, MD; Jianxing He, MD; Yuankai Shi, MD; Yizhuo Zhao, MD; Hao Yu, MD; Yang Zhao, MD; Weiqiang Chen, MD; Yi Luo, MD; Lin Wu, MD; Xiuwen Wang, MD; Robert Pirker, MD; Kejun Nan, MD; Faguang Jin, MD; Jian Dong, MD; Baolan Li, MD; Yan Sun, MD
Massachusetts Medical Society
Authors: H. Quimby Gallupe
Journal: New England Journal of Medicine (1949)

VETERANS IN FOREIGN MEDICAL SCHOOLSAt the meeting of the Council held on October 6 a resolution (as printed in the December 2 issue of the Journal) disapproving a policy of the Veterans Administration advising veterans that they may attend foreign medical schools at the expense of the Government was unanimously adopted by the Council.Copies of the resolution were sent to every Massachusetts senator and congressman. Each has received the following letter from the Veterans Administration concerning the problem:Honorable Richard B. WigglesworthUnited States RepresentativeMilton, MassachusettsDear Mr. Wigglesworth:This will acknowledge receipt of your letter . . .
A model of comparative effectiveness research (CER): The impact of biologic agents in a cohort of patients from ethnic minorities with metastatic colorectal cancer (mCRC).
Authors: Umang H. Shah, Ashish Abhay Khot, Dharmendra Goyal, Shuang Guo, Andreas Kaubisch, Lakshmi Rajdev, Sanjay Goel, Santiago Aparo
Journal: Journal of Clinical Oncology (2014)

e14503 Background: The role of biologic agents in the treatment of metastatic colorectal cancer (mCRC) has been studied in clinical trials. These studies included 90% patients (pts) of white race. Hispanics and blacks were largely underrepresented comparative effectiveness research (CER) allows exploration of the impact of biologic agents in a cohort composed largely of pts from minorities. We present the results of a cohort of pts served by Montefiore Einstein Cancer Center (MECC) in Bronx, NY. Methods: Pts diagnosed and treated for mCRC from January 2000 to December 2011 were identified using data from the MECC Cancer Registry. Pts demographic and clinical characteristics were extracted from pts medical records. A Cox proportional—hazard model was used to assess survival differences between pts treated with chemotherapy alone vs. pts treated with chemotherapy plus biologics. Results: A total of 293 pts where identified; 45% were black, 27% were Hispanic, and 28% were white. Of the pts receiving biologics, 90% received bevacizumab and 50% received cetuximab or panitumumab. The median overall survival was 15.2 months in the chemotherapy alone group and 25.6 months chemotherapy + biologics group (p=0.003). Univariate analysis showed that 1 metastatic site vs. 2, CEA <40 ng/mL, receiving 2 lines of chemotherapy and exposure to biologics were independently associated with longer survival. Multivariate analysis of the whole cohort (n=290), which included all ethnic groups, showed that exposure to biologics offered a survival benefit (HR of 0.70, 95%Cl 0.52-0.93, p=0.02), after adjusting for gender, age, CEA, number of metastatic sites and lines of chemotherapy received. Subgroup analysis based on ethnicity showed survival benefit for whites (HR of 0.38, 95%Cl 0.22-0.66, P=0.001) but not for Hispanics (HR of 0.65, 95%Cl 0.35-01.23, p=0.18) nor blacks (HR of 1.04, 95°/0C1 0.63-1.70, p=0.87). Conclusions: In this cohort weighted heavily towards ethnic minorities, the addition of biologics to chemotherapy was associated with longer survival, an effect mainly driven by whites. Hispanics and blacks did not seem to benefit from exposure to biologics. An effort should be made to include minority pts in ongoing clinical trials.
Evaluating Three Treatments for Borderline Personality Disorder: A Multiwave Study
Authors: John Clarkin
Journal: American Journal of Psychiatry (2007)

Objective: The authors examined three yearlong outpatient treatments for borderline personality disorder: dialectical behavior therapy, transference-focused psychotherapy, and a dynamic supportive treatment. Method: Ninety patients who were diagnosed with borderline personality disorder were randomly assigned to transference-focused psychotherapy, dialectical behavior therapy, or supportive treatment and received medication when indicated. Prior to treatment and at 4-month intervals during a 1-year period, blind raters assessed the domains of suicidal behavior, aggression, impulsivity, anxiety, depression, and social adjustment in a multiwave study design. Results: Individual growth curve analysis revealed that patients in all three treatment groups showed significant positive change in depression, anxiety, global functioning, and social adjustment across 1 year of treatment. Both transference-focused psychotherapy and dialectical behavior therapy were significantly associated with improvement in suicidality. Only transference-focused psychotherapy and supportive treatment were associated with improvement in anger. Transference-focused psychotherapy and supportive treatment were each associated with improvement in facets of impulsivity. Only transference-focused psychotherapy was significantly predictive of change in irritability and verbal and direct assault. Conclusions: Patients with borderline personality disorder respond to structured treatments in an outpatient setting with change in multiple domains of outcome. A structured dynamic treatment, transference-focused psychotherapy was associated with change in multiple constructs across six domains; dialectical behavior therapy and supportive treatment were associated with fewer changes. Future research is needed to examine the specific mechanisms of change in these treatments beyond common structures.
Consultants for The Journal in 1966
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lymph Circulation in Hepatic Cirrhosis: Effect of Portacaval Shunt.
Authors: M. H. Witte
Journal: Annals of Internal Medicine (1968)

s1 May 1968Lymph Circulation in Hepatic Cirrhosis: Effect of Portacaval Shunt.M. H. Witte, M.D., A. E. Dumont, M.D., W. R. Cole, M.D., C. L. Witte, M.D.M. H. Witte, M.D.Search for more papers by this author, A. E. Dumont, M.D.Search for more papers by this author, W. R. Cole, M.D.Search for more papers by this author, C. L. Witte, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-68-5-1150_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe ability of the lymphatic system to expand its capacity as an outflow tract for the liver and intestine in hepatic cirrhosis bears directly on thedevelopment of ascites and esophageal varices. To determine the relative contribution of the liver and intestine to increased thoracic duct lymph (TDL) formation in this disease, TDL was examined in 61 patients with cirrhosis (nutritional and postnecrotic) including 9 after portacaval shunt. TDL flow, pressure, protein content, and sulfobromophthalein (BSP) retention 45 min after intravenous injection (5 mg/kg body weight) were measured. Protein in regional lymph from the liver (LL) and small intestine (IL)... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: St. Louis, Missouri, and New York, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1968Volume 68, Issue 5Page: 1150-1151KeywordsCirrhosisInterleukinsIntravenous injectionsLiverLiver diseasesLymphLymphatic systemNutritionProteinsSmall intestine Issue Published: 1 May 1968 PDF downloadLoading ...
The So-Called Scoliosis of Infants
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pervasive Deficiencies
Authors: Mike Mitka
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal