tbuckley/cabot-search huggingface dataset:
Right Bundle-Branch Block
Authors: Andrew G. Kumpuris
Journal: JAMA (1979)

RIGHT bundle-branch block (RBBB) is an unusual complication of non-penetrating trauma to the chest. Rankin and Patterson<sup>1</sup>in 1952 and Parmley et al<sup>2</sup>in 1958 described transient intraventricular conduction defects that they concluded were due to myocardial contusion. We report a case of transient RBBB that developed following nonpenetrating chest trauma without myocardial injury as evidenced by serial ECGs, technetium Tc 99m pyrophosphate scan, and cardiac enzyme values. <h3>Report of a Case</h3> A 55-year-old man who had been previously healthy was seen in the emergency room of the Houston Veterans Administration Hospital following an automobile accident in which he had sustained blunt trauma to the anterior chest wall. His only complaint was of nonradiating pleuritic chest pain. The patient was in mild distress. The cardiac apical impulse was in the sixth intercostal space of the midclavicular line. His pain increased following firm palpation of the anterior chest wall. Otherwise,
Renal cell carcinoma with perirenal fat invasion: Is partial nephrectomy as good as radical surgery?
Authors: Mauricio Cordeiro, Diogo Assed Bastos, Fabio Pescarmona Gallucci, Joao Arthur Brunhara Barbosa, Eder Nisi Ilario, Paulo Afonso de Carvalho, Henrique T. S. Nonemacher, George Lins Albuquerque, Romulo Loss Mattedi, Arnaldo Fazoli Carvalho, William Carlos Nahas
Journal: Journal of Clinical Oncology (2017)

e16056 Background: Partial nephrectomy (PN) is the standard of care in the management of cT1a tumors, while radical nephrectomy (RN) is indicated in more advanced tumors. Recent studies provided evidence that PN could be performed in patients with tumors greater that 7 cm with complication rates and oncological outcomes comparable with those undergoing RN. This study compares the recurrence-free survival (RFS), overall (OS) and cancer-specific survival (CSS) of PN and RN in patients with non-metastatic pathological T3a renal cell carcinoma (RCC) with perirenal fat invasion only. Methods: We reviewed 1202 patients undergoing RN (n = 653) and PN (n = 549), at a oncological referral center, from January 2003 to June 2016. Of all patients, we identified 25 RN and 41 PN pT3a tumors with exclusively perirenal fat invasion. None had nodal or distant metastasis at pretreatment clinical staging. Patients characteristics were compared with Mann-Whitney U test and Student t-test for categorical and numeric variables with normal distribution, respectively. Both groups were compared for RFS, OS and CSS with a Kaplan-Meier survival analysis. Results: All patients included had pT3a stage with isolated perirenal fat invasion. Groups undergoing RN and PN were not significantly different regarding Charlson Comorbidity Index (Median 3 for RN vs 4 for PN, p = 0.24) or Age (Mean 65.3 for RN vs 62.0 for PN, p = 0.99). Patients undergoing RN had bigger tumors (7.9 cm vs 4.6, p &lt; 0.001) and higher Fuhrman grade (p = 0.01). Median follow-up was 36 months for RN and 34 months for PN. At the end of follow-up, recurrence was seen in 3 patients undergoing RN (12%) and 2 undergoing PN (5%), p = 0.36. Mortality was similar across groups (16% for RN vs 15% for PN, p = 0.99) as well as Cancer-specific mortality (4% for RN vs. 5% for PN, p = 0.99). At the end of follow-up, RFS was 80% (20/25) for RN and 82% (34/41) for PN. Conclusions: In our data, renal cell carcinoma with T3 stage due to perirenal fat invasion exclusively had similar outcomes when treated with Radical or Partial Nephrectomy. OS as well as RFS were comparable for both surgical modalities, suggesting that, although RN is currently the gold standard for this staging, PN may provide similar oncologic results.
Commentary
Authors: Mathieu Pioche
Journal: Endoscopy (2021)

Gastric hyperplastic polyps are a strange epithelial disease, lying somewhere between neoplasia [1] [2] and exuberant scarring facilitated by chronic liver disease or Helicobacter pylori infection. Therefore, it is theoretically preferable to check that the lesion is not neoplastic by resecting it although invasive cancers are rare. But recurrence after resection is not uncommon, and sometimes in an even more exuberant form [3]. This approach of Perisetti et al., by elastic ligation, is interesting if it reduces the risk of recurrence, though at the cost of not performing a histological analysis. Strategies combining band ligation and resection could be evaluated to solve the different issues if long-term follow-up and larger series revealed low recurrence rates with band ligation compared to endoscopic resections.
Atypical pyoderma gangrenosum with leukemia
Authors: S. J. Lewis
Journal: JAMA (1978)

Pyoderma gangrenosum (PG) has been increasingly reported in association with myeloproliferative disorders. Monoclonal gammopathy, myeloma, myeloid metaplasia, and polycythemia have all been found in association with PG. Recently, seven cases of PG in association with leukemia have been described: three cases with acute myeloblastic leukemia, two cases with chronic myelogenous leukemia, one case with acute lymphoblastic leukemia, and one case with acute leukemia of either plasma cell or myeloblast origin. To these we add two cases of PG with acute myeloblastic leukemia. These patients often have an atypical clinical presentation for PG, with bullae and relatively superficial involvement obscuring the correct diagnosis. (<i>JAMA</i>239:935-938, 1978)
Renin Inhibitors
Authors: Edgar Haber
Journal: New England Journal of Medicine (1984)

RENIN INHIBITORSIN the May 4, 1978, issue of the Journal, Gavras et al. reported the first clinical trial of a new agent that promised a different approach to the treatment of hypertension — the inhibition of the renin–angiotensin system.1 Renin, a proteolytic enzyme, is secreted by the juxtaglomerular cells of the kidney. It cleaves angiotensin I from a circulating protein substrate, angiotensinogen. Angiotensin I is in turn cleaved by another protease, converting enzyme, to form the potent pressor hormone, angiotensin II.The drug Gavras et al. tested was captopril, a converting-enzyme inhibitor that prevents the formation of angiotensin . . .
Cancer of the breast
Authors: J. A. del Regato
Journal: JAMA (1977)

IN THE Third National Cancer Survey (1969 to 1971), cancer of the breast was found to make up 27.5% of all cancer in white women and 23% of all cancer in black women.<sup>1</sup>In 1975 an estimated 88,700 new cases of cancer of the breast occurred in the United States; the risk, low for women younger than 25 years of age, rises thereafter and never declines, so that the older the patient, the greater her chance of having cancer of the breast. Progress made in this century in the diagnosis and treatment of malignant tumors has brought about a reduction in the mortality from some major forms of cancer: carcinoma of the cervix stands as a notable example. However, despite earlier diagnosis, reduced operative mortality, and the development of surgical adjuvants, there has been no reduction in the mortality from cancer of the breast. In the United States, the
Incorrect Values in Table
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
外泌汗腺与已确定的皮肤白色脂肪组织室内的人毛囊相关
Authors: E. Poblet, F. Jimenez, E. Escario-Travesedo, J.A. Hardman, I. Hernández-Hernández, J.L. Agudo-Mena, J.J. Cabrera-Galvan, C. Nicu, R. Paus
Journal: British Journal of Dermatology (2018)

一直以来的假设是汗腺分布于皮肤,未与毛囊相连(毛发“根部”)。与其相关的脂肪腺以及其他专用腺和使毛发站立的肌肉被统称为毛囊皮脂腺。换句话说,汗腺和毛囊皮脂腺一直被视为单独的结构,汗腺通向毛发之间(而不是毛发旁边)的皮肤表面。手掌和脚底的汗腺发育方式不同,因此不在本研究范围内。这项来自西班牙和英国曼彻斯特的研究使用多种技术,包括通过显微镜观察在毛发移植期间从头皮采集的毛囊剖面以及通过人工和计算机辅助3D方式重建头皮皮肤剖面,最后展现出,在生长毛发的区域,汗腺最深的部位(螺旋结构)实际上在脂肪腺和毛发肌肉连接点下方紧靠毛囊皮脂腺最深的部位,位于毛囊鞘旁。此外,这些结构聚集在从下层脂肪向上延伸至最低层皮肤(网状真皮层)的脂肪的锥形突出内。作者们推断,汗腺、毛囊皮脂腺和这种特殊的脂肪组织(统称为“附属皮肤单位”)会在特定皮肤病中和伤口愈合期间相互作用,也会与药物治疗发生反应。
THE DISPENSARY AS A FACTOR IN MEDICAL EDUCATION AND AS A DIAGNOSTIC CLINIC
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Use of Niacin During Non–ST-Segment Elevation Acute Coronary Syndromes—Reply
Authors: Ty J. Gluckman, Molly Sachdev, Steven P. Schulman, Roger S. Blumenthal
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Kokopelli
Authors: A. Vogl
Journal: JAMA (1970)

<h3>To the Editor.—</h3> In his article "Kokopelli of Indian Paleology" (<b>212</b>: 1678, 1970), Dr. Wellman finds the diagnosis of Pott's disease unlikely to account for the gibbus of the Kokopelli since it would appear incompatible with their liveliness, their physical fitness, their role as medicine men, the depicted location of a gibbus in the lumbosacral region, and the paralysis of the legs which is apparent on some of these pictures (Figure). May I draw attention to the fact that all this is not uncommonly found in achondroplastic dwarfs?<sup>1,2</sup>They are known for their strength and skill (many of them have been famous as circus clowns), their intelligence and wit (medieval paintings show them as court jesters), and they have enjoyed the reputation of having unusual sexual prowess. Many of the achondroplastic dwarfs have a prominent dorsolumbar gibbus, and quite a few develop paraplegia later in life due to the
Transactions of the Indiana State Medical Society.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Eleventh Annual Meeting of the International Society for Experimental Hematology
Journal: JNCI Journal of the National Cancer Institute (1982)

Eleventh Annual Meeting of the International Society for Experimental Hematology Get access JNCI: Journal of the National Cancer Institute, Volume 68, Issue 4, April 1982, Page 695, https://doi.org/10.1093/jnci/68.4.695-a Published: 01 April 1982
Bioavailability of Cd to Food Crops in Relation to Heavy Metal Content of Sludge-Amended Soil
Authors: Frank T. Bingham
Journal: Environmental Health Perspectives (1979)

Results of greenhouse and laboratory experiments on factors influencing uptake and accumulation of Cd by economic crops are summarized. Tolerance to Cd is highly crop-specific. For example, 21 different economic crops were grown in pots filled with a calcareous soil treated with increasing amounts of Cd. Yields versus Cd addition rate relations showed yield reductions to occur with Cd sensitive plants (spinach, soybean, curlycress, and lettuce) at addition rates varying from 5 to 15 μg Cd/g soil, whereas tolerant crops (tomato, squash, cabbage, and rice) did not suffer a yield reduction when treated at rates less than 150 μg Cd/g soil. Nutrient solution experiments likewise revealed marked differences in growth of crops. Corn, turnip, beets, bean, and tomato plants grown in solution cultures containing 0.1 μg Cd/ml accumulated different amounts of Cd in leaf tissue depending upon crop species; leaf Cd concentrations ranged from a low of 9 μg Cd/g leaf for beans to 200 μg Cd/g leaf for beets. Large differences also occur with regard to distribution of Cd within the plant. Fruit and seed tissue contain less Cd than leaves. Experiments comparing the toxicity of Cd to Cu, Ni, and Zn in an acid soil ± lime showed Cd to be the most phytotoxic. While interactive effects occur with regard to metal uptake and accumulation by plants, Cd uptake is essentially dependent upon the Cd concentration of the soil. Studies of chemical speciation of Cd in relation to Cd availability indicate that the free Cd2+ concentration correlates better with Cd uptake than Cd total of the soil solution.
Peroneal Tenography
Authors: Robert P. Eichelberger
Journal: JAMA (1982)

PERONEAL tenography, a radiological procedure, permits direct evaluation of peroneal tendon entrapment or displacement, as well as strong indirect evidence of calcaneofibular ligament tears. Although it has been described chiefly in the orthopedic literature previously, peroneal tenography is being requested of radiologists with increasing frequency. Our purpose is to describe the procedure and to present examples of the normal and abnormal findings that may be encountered. <h3>Indications</h3> Peroneal tenography provides anatomic definition of the peroneal tendons and their relationships to the lateral malleolus, calcaneus, and the lateral ligamentous structures of the ankle. The most common long-term complaints following fracture of the calcaneus are stiffness and inability to control the foot and ankle.<sup>1</sup>This inability results frequently in twisting or spraining the foot and ankle, as the patient is unable to resist the turning in (inversion) of the foot, particularly on irregular surfaces. Anatomically, this disability can be ascribed to
INDIGENT CARE
Journal: JAMA (1961)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
HARDLY THE CODE.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
EPCT-24 THE REMIND TRIAL: MULTI-ANTIGEN TARGETED T CELLS FOR PEDIATRIC CNS TUMORS
Authors: Melanie Grant, Maria Fortiz, Lu Wang, Haili Lang, Anushree Datar, Emily Reynolds, Madeleine Terpilowski, Ashley Geiger, Chris Lazarski, Jay Tanna, Adriana Pitino, Nan Zhang, Fahmida Hoq, Patrick Hanley, C Russell Cruz, Lindsay Kilburn, Roger Packer, Brian Rood, Catherine Bollard
Journal: Neuro-Oncology (2021)

Abstract Background Patients with relapsed CNS malignancies or DIPG face terrible prognoses. We hypothesized that T cells specific for 3 tumor-associated antigens (TAA), WT1, PRAME and survivin, would be safe and elicit anti-tumor immunity. Methods Patients (n=18) received autologous tumor antigen-associated T cells (TAAT) (up to 8x107/m2) for newly diagnosed DIPG (Group A) or recurrent CNS malignancies (Group B) on a Phase I dose-escalation study (NCT03652545) and were monitored for safety and response. Results/Discussion 16/18 patients who received TAAT completed the 45-day safety monitoring phase with no dose-limiting toxicities. Adverse events were minimal despite multiple pretreatments in Group B. Infused cells were predominantly CD3+ T cells (median 96%; range: 87–99%), with CD4+ and CD8+ comprising 16% (range: 5–87%) and 40% (range: 4–67%) respectively. Specificity for 1–3 TAAs was demonstrated in 11/18 TAAT by a-IFN-γ ELISPOT. Dose escalation is complete, and clinical and immunologic response assessments are ongoing. Plasma cytokine and proteomic analyses demonstrated dynamic post-infusion immune cytokine and protein responses. Consistent with an infusion-mediated immune response all patients in Grp A showed increased T cell effector, inflammatory and immune-stimulatory cytokines IFN-γ, TNF-α, IL-2, IL-5, IL-7, IL-1β, IL-6, IL-8, IL-12p70, IL-17A and GM-CSF at Weeks 1 and 2 post-infusion (n = 6). Of 9 patients who have been tested, 29/92 plasma proteins showed significant differences between dose levels 1 and 2, including increased IL-7 (p &amp;lt;0.0004) and CD40L (p &amp;lt;0.046) and reduced IL-4 (p &amp;lt;0.0004). T cell receptor sequencing showed expansion and persistence of clones detected in infusion products. In summary, TAAT have thus far been safe and elicit immune responses in vivo. Clinical and immunologic response assessments are ongoing.
Goya's living skeleton.
Authors: R H Park, M P Park
Journal: BMJ (1991)

Clusius used the copy ofthe "Colloquios" nov in Cambridge University library to prepare a Latin version that was used in European universities for the next two centuries copy of da Orta's Coloquios in Lisbon the year after its publication in Goa.He translated it into Latin; he also edited, annotated, and abridged it, trimmning it of nonmedical and anecdotal digressions.The new version, published in Antwerp in 1567, was titled Aromatum et Simplicium Aliquot Medicamentorum Apud Indios Nascentiun Historia.It achieved great popularity in European universities, ran into five editions in Clusius's lifetime, and is the form in which da Orta's original work was chiefly disseminated for the next two centuries.Clusius's own copy of the da Orta book, as originally published in Portuguese-autographed, dated (1564), and copiously annotated by the Flemish physician-lies in the Cambridge University library (fig 2).2 Staying on in GoaGarcia da Orta did not accompany his patron Affonso de Sousa back to Portugal, nor did he retire there to enjoy a prosperous old age, as did most colonials then and since.His decision to remain in Goa may have been due to political or religious exigencies,3 but also perhaps to the fact that the lush verdant beauty of Goa had hiiii in its spell.The picturesque beaches, ancient temples, and cosy villages with their pretty parish churches-all interlaced by drowsy, palm fringed roads-have changed little in the four centuries since my own ancestors inhabited a Goan village across the Mandovi River from where da Orta practised and Portuguese viceroys and inquisitors ruled.Nothing remains of the magnificent city of old Goa but half a dozen huge, empty (but well preserved) sixteenth century churches, one of which contains the mummified body of St Francis Xavier in a massive tomb of incredible splendour.Garcia da Orta himself has been commemorated in twentieth century Goa (now part ofIndia) not by tomb, bust, or statue but by a small public garden in an unfrequented nook of Panjim, the state's capital.