tbuckley/cabot-search huggingface dataset:
Book Reviews
Journal: Allergy (1985)

Book Reviews in this articles: Pepys, J. (Guest Editor): Clinics in immunology and allergy. Occupational respiratory allergy. Schwartz, R. S. (ed.): Immunology of anergy and systemic lupus erythematosus. Valette, L. &amp; Hennessen, W. (eds.): Brucellosis. Developments in biological standardization.
The Frequency of Genes for Hemochromatosis in Patients Attending a Health Appraisal Clinic
Journal: Annals of Internal Medicine (2000)

Summaries for Patients5 September 2000The Frequency of Genes for Hemochromatosis in Patients Attending a Health Appraisal ClinicSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-133-5-200009050-00003 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Hereditary hemochromatosis is a genetic disease in which iron is deposited in body tissues. Iron deposits can lead to serious liver damage (cirrhosis), diabetes, heart failure, arthritis, and bronze discoloration of the skin. When hemochromatosis is detected early, organ damage can be prevented by routinely removing blood. Standard screening tests for hemochromatosis include blood tests that indicate body levels of iron. Recently, a test was developed for the HFE gene, the gene that is most commonly affected in hereditary hemochromatosis. Three different mutations are known to occur in ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “The Effect of HFE Genotypes on Measurements of Iron Overload in Patients Attending a Health Appraisal Clinic.” It is in the 5 September 2000 issue of Annals of Internal Medicine (volume 133, pages 329-337). The authors are E Beutler, V Felitti, T Gelbart, and N Ho.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe Effect of HFE Genotypes on Measurements of Iron Overload in Patients Attending a Health Appraisal Clinic Ernest Beutler , Vincent Felitti , Terri Gelbart , and Ngoc Ho Correction: Summary for Patients on Genes for Hemochromatosis Victor Herbert Metrics 5 September 2000Volume 133, Issue 5Page: I-28KeywordsBloodFerritinGenetic diseasesHeart failureHematologic testsHemochromatosisLaboratory testsLiverMutationSerum ferritin levels ePublished: 5 September 2000 Issue Published: 5 September 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Hepatitis C virus c100 antigen in liver tissue from patients with acute and chronic infection
Authors: D Sansonno
Journal: Hepatology (1993)

A pool of murine monoclonal antibodies developed against c100 antigen, a hepatitis C virus–associated protein encoded by the NS3/NS4 virus genome, was used to detect hepatitis C virus in liver biopsy specimens from patients with acute and chronic hepatitis C virus infection. The antigen was present in the cytoplasm of liver cells only. The immunoreactive signal appeared as large, distinct, brilliant fluorescent granules with no clear relationship to cellular structures. No obvious membrane c100 antigen accumulation was observed. Distribution of c100-containing hepatocytes was directly correlated with viral replication in acute hepatitis. All three acute-hepatitis patients were positive for hepatitis C virus RNA (as detected on polymerase chain reaction) in serum and displayed c100 antigen in 50% to 70% of hepatocytes, with a distinct topographical relationship with necrotic areas and inflammatory cell accumulation. Conversely, very low numbers of infected cells and no relationship between tissue c100 antigen expression and sites of liver cell necrosis and inflammation were found in 14 chronic hepatitis C virus infection patients. Furthermore, though all patients had measurable levels of serum hepatitis C virus RNA, only eight (57%) had detectable c100 antigen in liver sections. Indeed, these two distinct immunopathological patterns were inversely related to the development of c100 antibody in serum. Specificity of hepatocellular c100 antigen deposits was established through extensive absorption experiments using structural and nonstructural hepatitis C virus recombinant proteins. However, tissue processing was found to be a crucial step in the demonstration of hepatitis C virus antigen in fresh frozen liver tissue. Furthermore, monoclonal antibodies against recombinant core and NS3-encoded proteins failed to demonstrate immunofluorescent staining, suggesting that the c100 protein is the main antigen demonstrable by this method. (HEPATOLOGY 1993;18:240–245).
Book Review Lymph Node Metastases: Incidence and surgical treatment in neoplastic disease . By Grantley W. Taylor, M.D., and Ira T. Nathanson, M.D. With a foreword by Shields Warren, M.D. 8°, cloth, 498 pp., with 61 illustrations and 117 tables. London: Oxford University Press, 1942. $8.00.
Journal: New England Journal of Medicine (1943)
MRFIT and the Oslo study
Journal: JAMA (1983)

THE LARGE American three-factor<sup>1</sup>and the much smaller Norwegian two-factor<sup>2</sup>coronary heart disease (CHD) prevention trials have come out with different results, the former ending inconclusively, the latter with a significantly reduced incidence of total cardiovascular and CHD end points, and substantial, although nonsignificant, reductions in CHD and total mortality. The Oslo diet-smoking trial in 1,232 high-risk, normotensive, healthy men aged 40 to 49 years, representing the 20% upper risk of a screened male population of 16,200, combined lipid-lowering dietetic intervention with smoking cessation advice. The trial lasted from five to 6 1/2 years. <h3>Differences Between the Trials</h3> There are two main differences in study design between the two trials. The Multiple Risk Factor Intervention Trial (MRFIT) combined hygienic-dietetic intervention measures against smoking and eating habits with drug treatment of the hypertensive subjects (almost two thirds of the intervention group), while the Oslo Study management decided to exclude
Transactions of the Medical and Chirurgical Faculty of the State of Maryland.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Hint to the Dilatory.
Journal: JAMA (1883)

—Several members, who read papers in some one of the Sections of the American Medical Association at the recent meeting in Cleveland and which were referred for publication, have not yet placed such papers in the hands either of the permanent Secretary or of the editor of the Journal. They will confer a favor upon themselves as well as upon the readers of the<i>Journal</i>if they will place the papers referred to in the hands of the editor as soon as practicable. If they do not, a late publication will be the fault of no one but themselves.
A CASE OF TABETIC CHARCOT'S SPINE
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Benefit of treatment of latent tuberculosis infection in individual patients
Authors: Claudia C. Dobler, Andrew Martin, Guy B. Marks
Journal: European Respiratory Journal (2016)

We read with interest the correspondence by K. Fluegge, which discusses inclusion of additional information in our recently published decision aid for treatment of latent tuberculosis infection (LTBI) [1]. K. Fluegge suggests that the dynamic robustness of the decision aid could be strengthened by including information on 1) treatment adherence, 2) transitional alternative treatment regimens ( e.g. transition from isoniazid to rifampicin after adverse events) and 3) ethnicity (as an indicator of tolerability to isoniazid based on genetics of isoniazid metabolism). High model complexity of a decision analysis for preventive tuberculosis treatment may result in overfitting <http://ow.ly/Y8erf>
Incorrect Number.
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ON01910, a non-ATP-competitive small molecule inhibitor of Plk1, is a potent anticancer agent
Authors: Kiranmai Gumireddy, M.V. Ramana Reddy, Stephen C. Cosenza, R. Boominathan, Stacey J. Baker, Nabisa Papathi, Jiandong Jiang, James Holland, E. Premkumar Reddy
Journal: Cancer Cell (2005)
Mail-order medication contains some surprises
Journal: JAMA (1982)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Neurology
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Adverse reactions to tetanus toxoid
Authors: R. L. Jacobs
Journal: JAMA (1982)

A retrospective review of 740 charts of patients with a history of adverse reaction to tetanus toxoid immunization was undertaken. The most common reactions, by history, were local edema and tenderness (33%), fever (15%), and anaphylactoid response (33%). Three patients who had a vesicular eruption at the immunization site were found to have delayed hypersensitivity to mercury. Thirty percent of the patients had received tetanus toxoid within one year and 55% within five years of evaluation. Reactive responses to immediate skin tests were exceedingly rare (&lt;1%). None of the challenge patients suffered an adverse reaction. (<i>JAMA</i>1982;247:40-42)
Purpura fulminans in a child with pneumococcal septicemia two years after splenectomy
Authors: M. M. Adner
Journal: JAMA (1970)

Two years after splenectomy for idiopathic thrombocytopenic purpura, a 5-year-old child developed pneumococcal septicemia and meningitis, purpura fulminans, and disseminated intravascular coagulation which was treated successfully with heparin sodium and antibiotics. It is probable that the removal of the spleen predisposed the patient to the development of the infection which, in turn, initiated the coagulopathy resulting in purpura fulminans.
Outcomes Management
Authors: Paul M. Ellwood
Journal: New England Journal of Medicine (1988)

We pay dearly for the possession of the intricate machinery which gives us our vivid imagination, our retentive memory, and that power by which we are able to grasp at each moment all the threads of our past experience and to weave them into a new fabric for the service of the present. Mischief begins when the demands of this service cannot be properly met.—James J. Putnam, M.D., Shattuck Lecture, 1899.1 When the President proclaimed in 1969 that our nation faced a health care crisis, it was not news to the medical community. Costs were surging. Patients were beginning . . .
Elevated mitochondrial gene expression during rat liver regeneration after portal vein ligation
Authors: Yasuhiro Shimizu, Hiroshi Suzuki, Yuji Nimura, Shigemi Onoue, Masato Nagino, Masashi Tanaka, Takayuki Ozawa
Journal: Hepatology (1995)

We explored the molecular basis of mitochondrial energy production during rat liver regeneration after portal vein ligation. Ligation of the left branch of the portal vein induces an increase in the weight of the nonligated lobe, counterbalancing the reduced weight of the ligated lobe. Using this model, we investigated changes in mitochondrial DNA-binding proteins, mitochondrial DNA, and mitochondrial messenger RNA (mRNA) in rat hepatocytes of the nonligated lobes. The amount of mitochondrial DNA-binding protein increased maximally (200% to 300% of the preoperative level) at 12 hours after the operation, before an increase (390%) in mitochondrial DNA content at 24 hours, and parallel to an increase (240%) in mitochondrial mRNA levels at 12 hours. These results suggest that the energy supply for liver regeneration is achieved through enhancement of mitochondrial DNA replication as well as transcription, in which the mitochondrial DNA-binding proteins probably play regulatory roles. We also found that in the nonligated lobes, mRNA levels of hepatocyte growth factor increased to a detectable level only 12 hours after the operation. These molecular biochemical data help explain why preoperative portal vein embolization, which is a modification of portal vein branch ligation, is an effective method to prevent posthepatectomy liver failure. (Hepatology 1995; 22:1222-1229.).
Hepatic nodules in patients with Budd-Chiari syndrome Service de Chirurgie, H�pital Antoine B�cl�re, Clamart, France, Service d'H�patologie, de Chirurgie, de Radiologie, H�pital Beaujon, Clichy, France
Journal: Hepatology (1995)

Non-destructive ultrasonic methods for testing biological materials are applied in medicine as well as in food engineering to determine the physical parameters and the quality of agricultural products and raw materials such as meat. The purpose of this work was to identify the simplest and the most accurate of five methods for sound velocity determination across the fibers of the porcine longissimus dorsi muscle. The through-transmission technique (TT) was used for ultrasound signal acquisition with 2 MHz transducers. The first two methods (M1, M2) are based on the acquisition of a single ultrasound signal in the analyzed material, another two methods (M3, M4) rely on the acquisition of two ultrasound signals in samples with different thicknesses (two-distance method) and the last method (M5) involves the acquisition of a single ultrasound signal in the analyzed material and the acquisition of a single ultrasound signal in distilled water at the same distance between ultrasonic transducers (relative method). The results were processed by the nonparametric Kruskal–Wallis test and compared with published data. The mean values of sound velocity obtained with the use of the above methods in pork samples at post-storage, room and vital temperatures were as follows: method M1-1549.2/1581.7/1597.4 m/s, method M2-1477.7/1509.8/1597.4 m/s, method M3-1552.0/1599.0/1623.3 m/s, method M4-1557.4/1598.3/1623.6 m/s, method M5-1554.3/1583.7/1598 m/s. The experiment indicates that the choice of method for determining sound velocity significantly influences the results. Two of the five analyzed methods (namely M3 and M4), which involved measurements of the time of sound wave propagation through samples of the same material with varied thickness, produced velocity values most consistent with published data.
Lectures on Some Important Points Connected with the Surgery of the Urinary Organs.
Authors: None E. W. A.
Journal: JAMA (1885)

This work is issued in the cheap students' form (cloth or paper) and is uniform with former volumes by the same writer. Included in this volume we find (Chap. III.) the essay on " Tumors of the Bladder," and digital exploration of that organ. This includes all that was found in the little book, "Tumors of the Bladder," with the exception of the colored plates, which were of slight importance. The remainder of the chapters are supplementary to what he has repeatedly published. In the discussion of improved lithotrity full credit is given to American surgeons for modern improvements, but exception is taken to Bigelow's introduction of the word " litholopaxy " as unnecessary. The author asserts that the increased size of Bigelow's instruments is objectionable, while admitting that " Bigelow's achievement has been to demonstrate that crushing a stone, even if large, and removing all the fragments from the
Abstract 1624: Antigen-independent <i>de novo</i> prediction of cancer-associated TCR repertoire
Authors: Bo Li
Journal: Cancer Research (2019)

Abstract Cancer-associated T cells play a critical role in mediating immune responses in the anti-tumor immunity. However, due to the complex nature of cancer antigens, and the limited experimental approaches for collecting antigen-specific T cells, it remains a difficult task in cancer immunology to detect cancer-associated T cells. In this project, we have developed an antigen-independent machine learning approach to perform de novo prediction of cancer-associated T cells. Specifically, we have discovered a signature in the CDR3 sequence that can distinguish cancer-associated T cells from others. We applied this signature to immune repertoire data to define a “cancer score”, which is related to the probability of a repertoire being cancer-associated. We applied this approach to investigate 15 sample cohorts from public domain. These cohorts cover healthy donors, viral infected individuals and cancer patients from both early and late stages. Surprisingly, we observed consistently and significantly higher cancer scores using the cancer patients’ immune repertoire data, while none of the non-cancer repertoire was significant compared to healthy donors. We therefore used repertoire cancer score as a single predictor for cancer status to distinguish cancer patients from healthy donors, and observed high prediction power measured by area under the ROC (AUROC) curves. The AUROC reached 0.90 for early breast cancer patients, which is better than a number of current early prediction methods based on cancer biomarkers, such as PSA, CA-125, CEA, etc. In addition, cancer scores derived from certain late-stage cancers are associated with patient response to checkpoint blockade therapies, suggesting that it may also be used in combination with existing biomarkers, such as PD-L1 expression or cancer neoantigen load, to improve the prediction of clinical outcome of these cancer types. We anticipate broad utilities of cancer scores in cancer diagnosis and immunotherapy prognosis with the rapidly accumulating TCR repertoire sequencing data in clinical studies. Note: This abstract was not presented at the meeting. Citation Format: Bo Li. Antigen-independent de novo prediction of cancer-associated TCR repertoire [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1624.