tbuckley/cabot-search huggingface dataset:
Anterior interbody fusion for treatment of cervical-disk conditions
Authors: D. F. Dohn
Journal: JAMA (1966)

This exhibit is based on a series of 210 anterior-cervical fusion operations performed at the Cleveland Clinic during the past six years. Its purpose is to elucidate the following: clinical manifestations of cervical-disk disease, diagnostic maneuvers useful in selecting patients for surgery, surgical technique, and clinical results. Anterior-cervical fusion was established as a clinical method for the treatment of cervical-disk problems in 1958.<sup>1-3</sup>There have been a number of subsequent reports of clinical experience with the procedure.<sup>4-7</sup>One of the difficulties in evaluating the results of the surgical treatment of cervical-disk disease, both from reported series and from the present series, has been the tendency to group together the various types of cervical-disk conditions without distinction regarding the clinical manifestations and disabilities. This has been unfortunate because each type presents different problems in management and the results should be considered separately. An attempt has been made in the
Traumatic rupture of the gallbladder with massive biliary ascites
Authors: D. J. Frank
Journal: JAMA (1978)

TRAUMATIC laceration of the gallbladder with subsequent bile leakage into the peritoneum (choleperitoneum) is a rare complication of blunt abdominal trauma. Fewer than 50 cases have been reported in the English literature. Most cases have involved either children or adolescents, as the incidence of accidents in this group is the highest. The occasional cases reported in adults are usually secondary to steering wheel or seat belt injuries. If no other visceral organ is damaged and there are no signs of shock or hemoperitoneum, the delay in diagnosis can be as long as six weeks. In the rare instance when the patient has known chronic liver disease and ascites, the diagnosis may be further delayed. We present a case in which the diagnosis was established seven weeks after admission with the aid of a "skinny-needle" percutaneous transhepatic cholangiogram (PTC). <h3>Report of a Case</h3> A 53-year-old man was admitted to the hospital
Complications of Urologic Surgery: Prevention and Management
Authors: Frank Hinman
Journal: JAMA (1977)

Here we have a book designed both to help us stay out of trouble and get us out of it once we are already in. The editors have lined up 28 outstanding urologic surgeons to tell us how. If surgical interventions were perfectly conceived and executed, complications would not occur. The authors, starting from this premise, describe operations readily available in texts or journals. But it is a convenience for the busy urologic surgeon to have the techniques reviewed for him. After explaining how to do the operation correctly, each author—himself an expert or he would not have been asked to write his chapter—describes what he conceives to be the troubles some surgeons get into (or which<i>he</i>may have endured). In each chapter, for each operation, we are told not only how we should have prevented complications (so we won't do it again), we are also taught how to
Randomized study of the treatment of phenobarbital overdose with repeated doses of activated charcoal
Authors: S. M. Pond
Journal: JAMA (1984)

We performed a prospective randomized study of the effectiveness of repeated oral doses of activated charcoal in the treatment of phenobarbital overdose. Ten comatose patients who required intubation and mechanical ventilation completed the protocol. Five patients received repeated doses of activated charcoal and sorbitol. Five other patients who received a single dose of charcoal and cathartic served as control subjects. The serum half-life of phenobarbital (mean ± SD, 36 ±13 hours) during repeated administration of charcoal and sorbitol was significantly shorter than that after charcoal administration was discontinued (93 ±7 hours) and shorter than the half-life in the single-dose group (93 ±52 hours). The length of time that patients in each group required mechanical ventilation, 39 ±24 hours (single-dose group) and 48 ±8 hours (repeated-dose group), did not differ significantly, nor did the time spent in the hospital. Although administration of repeated doses of activated charcoal to patients with phenobarbital overdose significantly increased the elimination of phenobarbital, it had no clear effects on the patients' clinical course. (<i>JAMA</i>1984;251:3104-3108)
Growth hormone replacement therapy
Authors: A. L. Rosenbloom
Journal: JAMA (1966)

Seven children with anterior hypopituitarism and two children with possible isolated growth-hormone deficiency have been treated with injections of human pituitary growth hormone (HGH) for periods of three months to 3 1/2 years. Administration of HGH was planned to demonstrate the minimal dosage and the maximal interval between injections which are efficacious in growth promotion. Weekly injections of 2.5 to 5 mg of HGH usually were effective in achieving normal or accelerated growth velocity for maturational age. Daily injections of one seventh the weekly dose were not effective, nor were single monthly injections of four times the weekly dose. In one patient, biweekly injections of 10 mg were as effective as weekly injections of 5 mg. Diminishing responsiveness with increasing duration of treatment was observed.
The coverage of cancer in the Israeli press
Authors: A. Kuten, N. Haim, E. Lev, G. Weimann
Journal: Journal of Clinical Oncology (2004)

6095 Background: Cancer, being a terminal and often incurable disease, is a source of fear and concern for people. One of the most important sources for medical information in general, and cancer specifically, is the mass media. The media can shape beliefs regarding health and influence people's decision making. The main hypothesis guiding this study, based on the theoretical framework of cultivation research, is that there will be considerable differences between media coverage and medical data regarding cancer in the Israeli population in terms of the types of cancer reported, and the emphasis on death in the context of the disease. Methods: A systematic content analysis was applied to test these hypotheses, examining all the press reports published in Israel's most popular daily newspapers during the year 2000. Data from the Israeli Ministry of Health was used for comparison with media reports. Results: The findings of the study are in accordance with the main hypothesis and show that media portrayals of cancer are not always reflecting the medical reality. Several explanations are offered to explain these findings, focusing mainly on the nature of news making and media selection as well on the impact of various interest groups such as pharmaceutical companies, hospitals, laboratories, oncology departments, and various organizations trying to promote awareness and raise funds for research. Conclusions: The findings of this study join a wide range of studies in different areas of human knowledge and judgments that have documented processes of constructing "mass-mediated realities" but in the case of a fatal disease the findings may have acute implications. No significant financial relationships to disclose.
Influence of gemfibrozil and clofibrate on metabolism of cholesterol and plasma triglycerides in man
Authors: Y. A. Kesaniemi
Journal: JAMA (1984)

Mechanisms for the hypolipidemic action of gemfibrozil were examined in seven patients with hypertriglyceridemia. In addition, seven hyperlipidemic patients were studied with and without clofibrate treatment to compare the mechanisms by which these two drugs lower plasma triglyceride levels. All patients were studied on a metabolic ward. The first month was a control period, followed by one month of either gemfibrozil or clofibrate therapy. During treatment with gemfibrozil, plasma total triglyceride levels decreased by an average of 51%, and triglyceride levels in very low—density lipoproteins (VLDLs) fell by 57%. Transport rates of VLDL triglyceride were determined by multicompartmental analysis following injection of tritiated glycerol as a precursor. Gemfibrozil decreased transport (production) of VLDL triglyceride by an average of 28% and increased the fractional catabolic rate (FCR) of VLDL triglyceride by 92%. Clofibrate reduced plasma total triglyceride values on an average of 32% and VLDL triglyceride values by 38%. In contrast to gemfibrozil, clofibrate did not change transport rates of VLDL triglyceride but increased the fractional catabolic rate of VLDL triglyceride by 35%. Gemfibrozil thus decreased production of VLDL triglyceride<i>and</i>enhanced its clearance, while clofibrate only increased clearance of VLDL triglyceride. On the average, plasma cholesterol levels did not fall during gemfibrozil treatment, but levels of cholesterol in high-density lipoproteins and in low-density lipoproteins increased by 31% and 11%, respectively. The drug produced a 30% increase in fecal excretion of neutral steroids and a 37% decrease in fecal excretion of bile acids. Outputs of total neutral steroids and net cholesterol balance thus remained unchanged. (<i>JAMA</i>1984;251:2241-2246)
THE CODE OF ETHICS.PRELIMINARY STATEMENT OF THE MINORITY OF THE COMMITTEE ON REVISION.
Authors: Henry D. Didama
Journal: JAMA (1893)

In a circular signed by the committee on revision, and published inThe Journal, November 19, 1892, every member of the Association was requested " to study anew the Code of Ethics and the Constitution and then inform the chairman of the committee on the following points: "1. Do you advise any change in these documents? "2. If you advise a change, please state specifically what that change shall be. In answering, state the section or sections you would strike out, or add to, or amend. Kindly give the exact phraseology that would best meet your views in the changes you suggest." In the same issue ofThe Journal, the present Code and Constitution were published in full for convenience of reference and study. Four months after this notice was sent to the members of the Association the committee met for conference in Buffalo. The number of letters received by the chairman indicating
ENDEMIC GOITER: THE LESSON FROM NEW ZEALAND
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fifth Annual Meeting of the Society for Clinical Trials
Journal: JNCI Journal of the National Cancer Institute (1983)

Journal Article Fifth Annual Meeting of the Society for Clinical Trials Get access JNCI: Journal of the National Cancer Institute, Volume 71, Issue 3, September 1983, Page 649, https://doi.org/10.1093/jnci/71.3.649-f Published: 01 September 1983
LETTER FROM PARIS.
Authors: None A. B.
Journal: JAMA (1889)

The Water of the Seine as a Causative of Typhoid Fever in Paris—Prof. Verneuil on the Immediate and Remote Results of Operations practiced for Local Tuberculosis—Extirpation of the Larynx—Codeine to obtain Anæthesia—Dr. Ricord's Will. It has often been asked whether the ravages made by typhoid fever among the Parisian population are not attributable to the water of the Seine which they are sometimes condemned to drink. In a report on this question, addressed to the Prefect of Police, the Council of Hygiene and of Public Salubrity pronounced its opinion in the affirmative. After having established that potable water is, in large cities the vehicle of typhoid fever, and that the distribution of water non-contaminated diminishes the number of cases of this malady in a proportion hardly credible. The reporter, Dr. Auguste Ollivier, arrived at this conclusion that as far as the water supply is concerned the sanitary condition of
Suicide Attempts Among Patients Starting Depression Treatment With Medications or Psychotherapy
Authors: Gregory Simon
Journal: American Journal of Psychiatry (2007)

Objective: This study compared the time patterns of suicide attempts among outpatients starting depression treatment with medication or psychotherapy. Method: Outpatient claims from a prepaid health plan were used to identify new episodes of depression treatment beginning with an antidepressant prescription in primary care (N=70,368), an antidepressant prescription from a psychiatrist (N=7,297), or an initial psychotherapy visit (N=54,123). Outpatient and inpatient claims were used to identify suicide attempts or possible suicide attempts during the 90 days before and 180 days after the start of treatment. Results: Overall incidence of suicide attempt was highest among patients receiving antidepressant prescriptions from psychiatrists (1,124 per 100,000), lower among those starting psychotherapy (778 per 100,000), and lowest among those receiving antidepressant prescriptions in primary care (301 per 100,000). The pattern of attempts over time was the same in all three groups: highest in the month before starting treatment, next highest in the month after starting treatment, and declining thereafter. Results were unchanged after eliminating patients receiving overlapping treatment with medication and psychotherapy. Overall incidence of suicide attempt was higher in adolescents and young adults, but the time pattern was the same across all three treatments. Conclusions: The pattern of suicide attempts before and after starting antidepressant treatment is not specific to medication. Differences between treatments and changes over time probably reflect referral patterns and the expected improvement in suicidal ideation after the start of treatment.
Ophthalmology
Authors: T. P. O'Brien
Journal: JAMA (1992)

It is fitting as ophthalmology celebrates the 75th anniversary of the American Board of Ophthalmology,<sup>1</sup>the first medical subspecialty examining board in the world, that ophthalmologists continue to make important scientific contributions not only to preserve vision, but also to decrease mortality from associated systemic diseases. The acquired immunodeficiency syndrome (AIDS) epidemic advances at alarming rates, and ophthalmologists are increasingly involved in providing care to its victims. Indeed, cytomegalovirus (CMV) retinitis is the most frequent opportunistic ocular infection in patients with AIDS,<sup>2</sup>with 20% developing retinitis due to CMV at some time in their lives.<sup>3</sup>If untreated, CMV retinitis ultimately results in blindness. Currently, two drugs are approved for treatment of CMV retinitis: ganciclovir (Cytovene, Syntex Laboratories, Inc, Palo Alto, Calif) and foscarnet (Foscavir, Astra Pharmaceutical Products Inc, Westborough, Mass). Both antiviral agents must be administered initially at high doses for induction therapy, followed by lifelong maintenance
Pulmonary Embolism
Authors: Hugh H. Hussey
Journal: JAMA (1973)

Dalen and Dexter<sup>1</sup>rightly emphasized the importance and the difficulty of diagnosing pulmonary embolism. The importance rests with the facts that the condition is frequent in hospitalized patients and that it is potentially lethal, constituting one of the three most common causes of death at the authors' hospital. The diagnosis is difficult because pulmonary embolism is a great masquerader. Thus, Dalen and Dexter named four different clinical syndromes: (1) pulmonary infarction, (2) acute cor pulmonale, (3) acute, unexplained dyspnea, and (4) aggravation of preexisting left ventricular failure. The diagnosis is assisted, of course, when a source for emboli is identified, such as evidence of phlebothrombosis in the deep veins of the calf (calf tenderness, positive Homans sign, slight cyanosis of the leg and prominence of superficial veins when the legs are dependent, an abnormal phlebogram). In the table accompanying their essay, the authors listed the important emergency diagnostic tests
Failure of recombinant FVIIa as treatment for abdominal bleeding in acquired hemophilia
Authors: M. Makris, K.K. Hampton, E.E. Preston
Journal: American Journal of Hematology (2001)

To the Editor: Mutations in the factor XI gene are responsible for a variable bleeding phenotype which correlates poorly with levels of circulating FXI product.We read with interest and concern an article published recently describing a novel nonsense mutation [1].The authors state in their discussion that "eighteen causative mutations of the congenital FXI deficiency have been reported: three nonsense mutations, ten missense mutations, and five splicing site abnormalities.Three nonsense mutations are located in exons 5 and 7, which truncate the proteins in the middle of the second and third apple domains, respectively".To our knowledge, prior to the publication of their paper, only two nonsense mutations had been described for the FXI gene, both in exon 5 [2,3].No nonsense mutation has been described in exon 7. Also, only three splicing site abnormalities have been described, not five [2,4] (Table I).Additionally, an important omission was the 14-bp type IV deletion described in Askenazi Jews [5].
THE MODERN HOSPITAL
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Contempo '81. Computers in the clinical laboratory. New problems and new solutions
Authors: A. F. Krieg
Journal: JAMA (1981)

<h3>The Physician-Laboratory-Physician Communication Loop</h3> During the past few years, we have seen steady progress toward improved accuracy and precision in the clinical laboratory. New methods, new instruments, and new quality-control systems have decreased the frequency of laboratory error due to improper analysis. Improved analytic performance means that an increasing percentage of laboratory problems are now related to communication and interpretation of results.<sup>1-3</sup>Some common problems include (1) requests that never reach the laboratory; (2) reports that never reach the patient chart; (3) unreasonable delays in the cycle of request-analysis-report; and (4) "data overload"—as the volume of laboratory data increases, interpretation becomes increasingly difficult. In some settings, more than 10% of requests never reach the laboratory; more than 10% of reports never reach the patient chart; more than 10% of results do not reach the attending physician while still relevant; and other results have little or no value in terms
Integrative Medicine
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Immediate reduction of microvascular resistances following abciximab administration in unstable angina. Insight into the mechanism of action of GPIIb/IIIa inhibitors Mario Marzilli, Gianmario Sambuceti, Roberto Testa, Silvio Fedele. Cardio Thoracic Dept, University of Pisa, Pisa, Italy, Institute of Clinical Physiology, CNR, Pisa, Italy
Journal: Journal of the American College of Cardiology (2001)
Asthma. Hay Fever and Related Disorders: A Guide for Patients.
Journal: JAMA (1933)

Musser 's book, like Cecil-s, is exclusively of United States' authorship.Perhaps the ideal text is yet to be compiled which shall be a composite of international medicine though the difficulties besetting its editorship might well be discouraging.In this text a novelty has been introduced in the matter of classification.Internal diseases are grouped in four parts: (1) infectious diseases; (2) systemic diseases, including circulatory,.respiratory, alimentary, urinary, endocrine, blood, spleen and reticulo-endothelial, and locomotor; (3) diseases of nutrition, allergy, metabolism, physical and chemical agents; (4) diseases of the nervous system, including mental disorders and organic diseases of the nervous system.While it is doubtful if this arrangement