tbuckley/cabot-search huggingface dataset:
Correction
Journal: BMJ (1950)

ANY QUESTIONS?BRrIJrAL solution of potassium permanganate (1 in 4,000) with subse- quent scraping with the edge of a glass slide and the applica- tion of iodine, dithranol, or other fungicide.Fractional doses of x rays may be tried, either alone or with these measures, but no treatment is very successful, and treatment even after surgical removal fails in a considerable proportion of cases.Some fungi penetrate more deeply into the nail substance than others and are in consequence less easily cured.Wom Incisors Q.-Can anything be done to improve the appearance when the upper incisors begin to wear down in middle age ?A.-The remedy is the construction of porcelain or acrylic jacket crowns.The discoloured enamel is removed from the teeth and replaced by a shell of porcelain or acrylic resin.With this method of crowning the nerve of the tooth is left intact. Allergic RhinitisQ.-What investigations should be carried out to establish a diagnosis of allergic rhinitis ?What is the treatment ?Is there any known association between allergic rhinitis and glucose tolerance or gastric acidity ?A.-The patient should be asked about the mode of onset and any seasonal incidence of the symptoms, and about his occupation and environment, with special reference to any food, dust, or other specific factor which might be a cause of the symptoms.Any substances suspected can be tested by appropriate cutaneous tests to ascertain if the patient is sensi- tive to it.If such sensitivity is established, treatment consists in avoiding the allergen where possible, a carefully graduated course of injections to desensitize the patient, or, if multiple sensitivity is present, a combination of these.Many allergic patients have some degree of achlorhydria, and children who suffer from asthma have low blood sugars in over 60% of cases." Chloromycetin " and Hoarseness Q.-Can chloromycetin ever produce hoarseness or aphonia ?A.-The most serious " toxic " effect of chloromycetin is the production of mucous membrane lesions.These commonly affect the tongue, mouth, and throat and give rise to infection, oedema, and pain." Black tongue" has been described.The lesions are probably due to yeast infection, and it has been suggested that induced riboflavin deficiency may be a factor in causing these changes.Hoarseness and aphonia might well result, but the writer has not seen it reported.Less commohly, proctitis, vaginitis, and perineal irritation may occur and may persist for a considerable time after treatment is stopped.Nausea, anorexia, and diarrhoea are common symptoms during chloromycetin administration.
Follicle-stimulating isohormones: characterization and physiological relevance
Authors: A. Ulloa-Aguirre
Journal: Endocrine Reviews (1995)

Journal Article Follicle-Stimulating Isohormones: Characterization and Physiological Relevance Get access Alfredo Ulloa-Aguirre, Alfredo Ulloa-Aguirre 1Department of Reproductive Biology, Instituto Nacional de la Nutricioón "Salvador Zubirán," 14000 Mexico D.F., Mexico (A.U.-A); and Department of Pediatrics and the Reproductive Sciences Program, University of Michigan Ann Arbor, Michigan 48109-0718 *Address reprint requests to: Alfredo Ulloa-Aguirre, M.D., D.Sc, Department of Reproductive Biology, Instituto Nacional de la Nutricioón "Salvador Zubirán," 14000 Mexico D.F., México, or Vasantha Padmanabhan, Ph.D., Department of Pediatrics, D3253 MPB, Box 0718, The University of Michigan, Ann Arbor, Michigan 48109. Search for other works by this author on: Oxford Academic Google Scholar A. Rees Midgley, Jr., A. Rees Midgley, Jr. 1Department of Reproductive Biology, Instituto Nacional de la Nutricioón "Salvador Zubirán," 14000 Mexico D.F., Mexico (A.U.-A); and Department of Pediatrics and the Reproductive Sciences Program, University of Michigan Ann Arbor, Michigan 48109-0718 Search for other works by this author on: Oxford Academic Google Scholar Inese Z. Beitins, Inese Z. Beitins 1Department of Reproductive Biology, Instituto Nacional de la Nutricioón "Salvador Zubirán," 14000 Mexico D.F., Mexico (A.U.-A); and Department of Pediatrics and the Reproductive Sciences Program, University of Michigan Ann Arbor, Michigan 48109-0718 Search for other works by this author on: Oxford Academic Google Scholar Vasantha Padmanabhan Vasantha Padmanabhan 1Department of Reproductive Biology, Instituto Nacional de la Nutricioón "Salvador Zubirán," 14000 Mexico D.F., Mexico (A.U.-A); and Department of Pediatrics and the Reproductive Sciences Program, University of Michigan Ann Arbor, Michigan 48109-0718 Search for other works by this author on: Oxford Academic Google Scholar Endocrine Reviews, Volume 16, Issue 6, 1 December 1995, Pages 765–787, https://doi.org/10.1210/edrv-16-6-765 Published: 01 December 1995
Blood, New York
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Legionella bozemanii. Still another cause of pneumonia
Authors: J. D. Sobel
Journal: JAMA (1983)

<i>LEGIONELLA bozemanii</i>was first isolated from lung tissue by Bozeman in 1959. The isolate came from a healthy scuba diver in Florida with fatal bronchopneumonia and was termed<i>WIGA</i>.<sup>1</sup>A second isolate, MI-15, was recovered in 1979 from lung tissue from a patient with lymphatic leukemia in whom a fulminant pneumonia developed after submersion in brackish swamp water.<sup>2</sup>In both cases, the organism was recovered on charcoal yeast extract (CYE) by guinea pig inoculation. Testing of the patient's serum sample with indirect fluorescent antibody (FA) showed an increase in antibody titer against both the MI-15 and WIGA isolates. Genetic and antigenic studies subsequently showed that the two isolated belonged to the same species. The proposed species name was<i>L bozemanii</i>.<sup>3</sup> In addition, the Centers for Disease Control (CDC), Atlanta, found serologic evidence of the association of<i>L bozemanii</i>in ten other cases of community-acquired pneumonia.<sup>4</sup>Immunofluorescent
Hepatology Highlights
Authors: Muhammad Amir, Ravi S. Vora, Zaid H. Tafesh, Arun Jesudian, Vikas Gupta, Robert E. Schwartz, Nick Russo, Christopher J. Danford, Daryl T.Y. Lau, Robert S. Brown, Nidhi Jalan‐Sakrikar, Jessica L. Maiers, Rajani Sharma, Brett E. Fortune, Moira Hilscher, Sayed Obaidullah Aseem
Journal: Hepatology (2019)

Amir, Muhammad; Vora, Ravi S.; Tafesh, Zaid H.; Jesudian, Arun; Gupta, Vikas; Schwartz, Robert E.; Russo, Nick; Danford, Christopher J.; Lau, Daryl T.Y.; Brown, Robert S. Jr; Jalan‐Sakrikar, Nidhi; Maiers, Jessica L.; Sharma, Rajani; Fortune, Brett E.; Hilscher, Moira; Aseem, Sayed ObaidullahEditor(s): Brown, Robert S. Jr.5; Schwartz, Robert E.5 Author Information
Abstract 1124: S100A14 suppresses metastasis of nasopharyngeal carcinoma via inhibition of NF-kB signaling
Authors: Dong-Fang Meng, Chao-Nan Qian
Journal: Cancer Research (2019)

Abstract Nasopharyngeal carcinoma (NPC) has a high incidence rate in southern China and Southeast Asia. Distant metastasis is the main reason for treatment failure. By analyzing our previously published whole genomic expression profiling data comparing low- versus high-metastasis NPC cells, we found that S100A14 expression was dramatically suppressed in high-metastasis cells. The reduced expression of S100A14 protein in the primary NPC collated with poorer overall survival of the NPC patients. Our preliminary experiments showed that S100A14 could inhibit the migratory and invasive abilities, as well as the epithelial-mesenchymal translation of NPC cells. RNA sequencing analyses found that NF-kB signaling pathway was the most dramatically influenced pathway by S100A14 with a negative relationship found between S100A14 and NF-kB signaling. We therefore propose a hypothesis that S100A14 inhibits NPC metastasis through inhibition of NF-kB signaling. In the proposed study, we will use a series of in vitro and in vivo approaches to clarify the inhibitory effects of S100A14 in terms of nuclear localization of P50 and P65, expression of IL-1beta, phosphorylation activation of the key molecules in NF-kB signaling pathway, as well as the in vivo metastasis of NPC cells. The accomplishment of the proposed study will reveal a novel mechanism of inhibiting NPC metastasis via inhibitory effects of S100A14 upon NF-kB signaling, which should be composed of drugable targets for metastasis prevention and treatment. Citation Format: Dong-Fang Meng, Chao-Nan Qian. S100A14 suppresses metastasis of nasopharyngeal carcinoma via inhibition of NF-kB signaling [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1124.
A Text-Book of Therapeutics Including the Essentials of Pharmacology and Materia Medica.
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Manual of Normal Physical Signs.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Genetic Milestone
Authors: Joan Stephenson
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Achieving hepatitis C elimination in people who inject drugs - interim results of an innovative screen-and-treat program in Austria
Authors: Caroline Schmidbauer, Raphael Schubert, Angelika Schütz, Cornelia Schwanke, Enisa Gutic, Roxana Pirker, Tobias Lang, Thomas Reiberger, Hans Haltmayer, Michael Gschwantler
Journal: Journal of Hepatology (2020)
Studies Raise Doubts About Benefit of Athletics in Reducing Unhealthy Behavior Among Adolescents
Authors: Andrew A. Skolnick
Journal: JAMA (1993)

ATHLETICS has been regarded widely as a means of encouraging children and adolescents to develop healthy habits and steering them away from smoking, drug abuse, and other detrimental behavior. Recent studies, however, raise some doubts about the role of sports in fostering healthy habits among the young. At the 40th annual meeting of the American College of Sports Medicine, held in Seattle, Wash, new data were presented. Deborah J. Aaron, a doctoral student in epidemiology at the University of Pittsburgh (Pa) Graduate School of Public Health, reported preliminary findings of a 3-year longitudinal study of high-risk behavior among children in a metropolitan school district near Pittsburgh. Results from the first year suggest that school- and community-based athletic programs may provide little overall benefit in discouraging unhealthy behavior among adolescents, Aaron says. In a related presentation at the conference, UCLA School of Medicine, Los Angeles, Calif, researchers reported study findings suggesting
Use of the Internet for Health Information and Communication
Authors: Tracey Bessell, Jeremy Anderson, Lloyd Sansom, Janet Hiller
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction
Authors: C Anah, Henry Hutchinson, Stewart Pre-Medical Scholar- Ship, P Mayne, Francis Andrew, Kathleen Dixon, B Medal, T Pringle, G Walter, G Smith Prize, P Prize, Smith Aquilla, Susan Prize, Craig Memorial Prize, Carolyn De Wolfe, Wytt Ball Prizes, J Heaney, M Asbury, K Fitz-Patrick, Norman Memorial, M Hartman, Friel Sheldon, D Prize, M London, D.-A Ho, M Moss, Nina Wedderburn, Welsh Wales, M Roberts, J Owen-Thomas, G Randle, S Khaliq, J Clark, G Foster, R Grieve, I Harrison, A Owen, C Weatherley, M -', Brigid Davison, R Hunter, J Jacques, J Morrison, M Scott, R Clarke, L Mcardle, D Oreopoulos, R Sinniah, B -', J Bryars
Journal: BMJ (1969)
Topotecan weekly versus routine 5-day schedule in patients with platinum-resistant ovarian cancer (TOWER): A randomized, multicenter trial of the North-Eastern German Society of Gynecological Oncology (NOGGO)
Authors: J. Sehouli, G. Oskay-Oezcelik, D. Stengel, P. Harter, C. Kurzeder, A. Belau, A. Belau, S. Markmann, R. Lorenz, L. Mueller, W. Lichtenegger
Journal: Journal of Clinical Oncology (2009)

5553 Background: In women with platinum-resistant recurrent ovarian cancer, weekly administration of topotecan (Tw) may be equally effective, but better tolerated than conventional 5-day dosing (Tc). We conducted a randomized multicenter trial to validate this assumption. Methods: The trial was pre-registered at clinicaltrials.gov ( NCT00170677 ). Women with platinum-resistant ovarian and fallopian tube cancers or primary peritoneal carcinoma, and measurable or assessable disease (GCIG criteria) were randomized to receive either Tw (d1,8,15/q28d, 4 mg/m 2 ) or Tc (d1–5/q21d, 1.25 mg/m 2 ). The predefined stopping rule, based on the primary endpoint of best CA-125 or tumor response, was not reached (presented at ASCO 2007, Abstract 5526). This permitted the accrual of 194 patients, 154 of whom could be assessed for CA-125 or tumor response (SD + CR + PR). We also compared progression-free (PFS) and overall survival (OS), as well as toxicity between trial groups. Results: Mean age was 61.8 (SD 9.8) years, and 59 women were on third-line treatment. Patients received a total of 809 cycles of chemotherapy. Demographic baseline characteristics, tumor stages and grades, and previous lines of chemotherapy were well balanced between treatment groups. There were 35 / 75 (47%) and 45 / 79 (57%) responses in the Tw and Tc groups, respectively (risk ratio [RR] 1.22, 95% CI 0.89–1.66). Median PFS and OS did not differ markedly between both regimens (3.2 versus 4.4 months, hazard ratio [HR] 1.30, 95% CI 0.96–1.77 and 9.8 versus 10.0 months, HR 1.08, 95% CI 0.77–1.52). The risk of grade III/IV hematological toxicity was significantly lower in the Tw group (anemia: RR 0.35, p = 0.007, neutropenia: RR 0.38, p = 0.0001, thrombopenia: RR 0.23, p = 0.0004). Conclusions: Weekly administration of topotecan shows no substantial difference in endpoints of effectiveness compared to conventional dosing, but is associated with a significantly lower likelihood of severe hematological toxicity. Weekly topotecan should be considered as a possible treatment alternative in women with platinum-resistant ovarian cancer because of its favourable benefit-risk-profile. No significant financial relationships to disclose.
Rethinking Warfarin for Atrial Fibrillation
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2022 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lectures ON DISEASES OF THE MALE URETHRA
Authors: F. S. Kidd
Journal: BMJ (1917)

<b>Background:</b> Body system impairments following stroke have a complex relationship with functional activities. Although gait and balance deficits are well-documented in people after stroke, the overlapping influence of body impairments makes it difficult to prioritize interventions. <b>Objective:</b> This study examined the relationship between prospectively selected measures of body function and structure (body mass index, muscle strength, sensation, and cognition) and activity (gait speed, gait endurance, and functional balance) in people with chronic stroke. <b>Design:</b> This was a cross-sectional, observational study. <b>Methods:</b> Twenty-six individuals with mean (SD) age of 57.6 (11) years and time after stroke of 45.4 (43) months participated. Four variables (body mass index, muscle strength difference between the lower extremities, sensation difference between the lower extremities, and Mini-Mental Status Exam score) were entered into linear regression models for gait speed, Six-Minute Walk Test distance, and Berg Balance Scale score. <b>Results:</b> Lower-extremity strength difference was a significant individual predictor for gait speed, gait endurance, and functional balance. Cognition significantly predicted only gait speed. <b>Limitations:</b> The authors did not include all possible factors in the model that may have influenced gait and balance in these individuals. <b>Conclusions:</b> Strength deficits in the hemiparetic lower extremity should be an important target for clinical interventions to improve function in people with chronic stroke.
An Address Delivered at the Opening of the Section of Psychology
Authors: F. Needham
Journal: BMJ (1890)

RBtraint.-ChemicalRstraint.-TheImprovement in Atten- dant and Nurses.-Ladiesas Nurses.-TheValue of Outdoor Exercise.-TheStudy of the Pathology of Insanity.-TheThera- peutics of Insanity.-Drugsand their Uses
Cardiac rupture. Three operations with two long-term survivals
Authors: B. W. Cobbs
Journal: JAMA (1973)

The first two long-term survivors treated surgically for cardiac rupture after myocardial infarction have been followed up for one and three years. Acute electromechanical dissociation in a patient previously without serious hemodynamic problems after a myocardial infarction is the cardinal feature, allowing the diagnosis of most salvageable cases. Immediate and, if necessary, continuous pericardicentesis, volume loading, and the administration of inotropic amines may give enough time for surgical intervention in some patients.