tbuckley/cabot-search huggingface dataset:
The gut and dermatitis herpetiformis.
Journal: BMJ (1971)

5between various scientific disciplines will be encouraged, and it is hoped that the club will stimulate research.At its meeting the club will consider the size of the problem, the importance of back pain in the community, and its incidence in various types of industry.Occupational backache is common, and if the factors leading to it can be accurately defined then it should be avoidable.A session is being devoted to the structure and formation of the spine.Our knowledge of the pathology of spinal disease has been limited by the relative difficulty in obtaining pathological material.Present lines of research include measurements of the pressures within the nucleus pulposus, studies of the anatomical and functional structure of the annulus fibrosus, and calculation of forces acting through the intervertebral discs.Another session will be concerned with biochemistry.Recently it has been appreciated that the strength of collagen depends on the intermolecular and intramolecular cross- linkages and that age changes in collagen are directly dependent on alteration in these.The structure of the annulus fibrosus is obviosly of great interest.Finally the meeting is considering how back pain affects the lives of its sufferers.Though many forms of treatment have their advocates, none are satisfactory.Evern among anecdotal reports of cures of back pain when all other treatments have failed some clues may be found to fruitful research.
MEDICAL EXPERTS.
Authors: WILLIAM S. FORREST
Journal: JAMA (1894)

Justice can not be administered in our civil or criminal courts without the aid of medical science. In the detection of crime, in the demonstration of innocence, in determining the probable cause, nature and extent of personal injuries, in shedding light upon the validity of wills, in ascertaining the existence and degree of mental impairment, the courts are compelled to lean upon the special research, observation and experience of the physician. Originally, in England the medical expert aided the court by reporting to him his conclusions somewhat as is now done by a Master in Chancery. In those days he was selected by the judge and not examined by counsel. That system failed, and in its place arose the present system, which requires the expert to respond to a subpœna, if his reasonable charges are tendered him, and to submit, under oath, to examination and cross-examination. There is nothing, however,
FECAL FATS
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Shoe contact dermatitis
Authors: E. Epstein
Journal: JAMA (1969)

Allergy to shoes is a fairly common problem in a dermatologist's practice. In a five-vear period 43 cases were documented. Shoe dermatitis is often incorrectly diagnosed as fungus infection, atopic eczema, or psoriasis. Employing only clinical criteria in the diagnosis of foot dermatoses can be misleading since shoe contact dermatitis may involve such "atypical" areas as the soles and is often not symmetrical. Proper patch testing with portions of the patient's own shoes is essential in making a diagnosis and is helpful from the standpoint of treatment. A shoe "screening tray" of rubber additives and other chemicals is a useful adjunct. As rubber-based adhesives or lining materials are the most commonly encountered offenders, finding suitable nonallergenic foot-wear can be a difficult problem. The majority of patients do well once the diagnosis is made.
Reply
Authors: Rahima A. Bhanji, Kymberly D. Watt
Journal: Hepatology (2018)

Potential conflict of interest: Nothing to report. We thank Dr. Peng for the interest in our recent review.1 Two important points regarding the interaction of nonalcoholic fatty liver disease (NAFLD) and sarcopenia are raised that we appreciate the opportunity to highlight. First, the importance of defining sarcopenia. We agree, a unified definition of sarcopenia is important, moving forward, as it will reduce heterogeneity between studies and provide a more accurate prevalence of this entity.2 Second, Dr. Peng's observation regarding higher body mass index (BMI) in studies showing correlation between NAFLD and sarcopenia may be in part explained by the presence of sarcopenic obesity, defined as the presence of sarcopenia in an individual who is overweight.3 This entity has been associated with reduced survival,4 and differentiating it from the presence of sarcopenia alone may not be clinically relevant as both entities are associated with poor clinical outcomes.4 BMI values are not ideal measures of obesity, and a high BMI or obesity serves as a deterrent to identifying sarcopenia and its prognostic influence. The other point brought forward is the assessment of patients with differing etiologies separately (i.e., NAFLD/nonalcoholic steatohepatitis versus end‐stage liver disease [ESLD] due to other etiologies). Most studies to date have looked at sarcopenia in all patients with ESLD. Recent studies have shown that the pathophysiology of sarcopenia is multifactorial and may have significant overlap with conditions including NAFLD or alcohol use, but the effect of sarcopenia may not be different.5 We agree that more data are needed on the prevalence and impact of sarcopenia in patients with varying etiologies of ESLD. We thank Dr. Peng for highlighting these important issues.
THERAPEUTIC DECADENCE IN BRITAIN.
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
GENE-50. SWI/SNF COMPLEX HETEROGENEITY RELATES WITH POLYPHENOTYPIC DIFFERENTIATION, PROGNOSIS AND IMMUNE RESPONSE IN RHABDOID TUMORS
Authors: Sriram Venneti, Pooja Panwalkar, Drew Pratt, Chan Chung, Derek Dang, Paul Lee, Daniel Martinez, Jill Bayliss, Kyle Smith, Mike Adam, Steve Potter, Paul Northcott, Leo Mascarenhas, Jared Shows, Bruce Pawel, Ashley Margol, Annie Huang, Alexander Judkins
Journal: Neuro-Oncology (2019)

Abstract PURPOSE Rhabdoid tumors (RTs) arise within (Atypical Teratoid/Rhabdoid Tumor-AT/RT) or outside the brain (extraCNS-RT-eCNS-RT) and are driven mainly by inactivation of the SWI/SNF complex subunit SMARCB1. A pathognomonic hallmark of RTs is heterogeneity characterized by multilineage differentiation of tumor cells including anomalous neuronal differentiation in a subset of eCNS-RT. The mechanisms that regulate heterogeneity in RTs are unknown. Because remodeling of the SWI/SNF complex regulates differentiation, we hypothesized that SWI/SNF-BAF and PBAF complex heterogeneity correlates with both multilineage differentiation and clinical outcome. EXPERIMENTAL DESIGN: We performed an integrated analysis of SWI/SNF complex subunit alterations in the developing kidney and cerebellum (most common regions of origin for RT) in comparison to eCNS-RT (n=14) and AT/RT (n=25) tumors. RT samples were interrogated using immunohistochemistry, DNA methylation and gene expression analyses. RESULTS (A) The SWI/SNF-BAF paralogs ACTL6A/ACTL6B were expressed in a mutually exclusive manner in the developing cerebellum and kidney. In contrast, a subset of eCNS-RTs lost mutual exclusivity and co-expressed both subunits. These tumors showed aberrant DNA methylation of genes that regulate neuronal and renal development and demonstrated immunohistochemical evidence of neuronal differentiation. (B) Low expression of the PBAF subunit-PBRM1 identified a group of AT/RTs in younger children with better overall prognosis. PBRM1-low AT/RT and eCNS-RTs showed altered DNA methylation and gene expression in immune-related genes accompanied by increased CD8 cytotoxic T-cell infiltration. CONCLUSIONS Heterogeneity in SWI/SNF BAF (ACTL6A/ACTL6B) and PBAF (PBRM1) subunits correlates with histogenesis, contributes to the immune microenvironment and prognosis in RTs and may inform opportunities to develop immunotherapies.
Young Blood
Authors: Alessandro Laviano
Journal: New England Journal of Medicine (2014)

Aging, a process associated with progressive functional decline of organs and tissues, is inevitable. Increased physical dependence and progressive cognitive impairment are therefore observed in large proportions of many populations. At the clinical level, aging frequently translates into frailty — in other words, a poor ability to adapt to the environment, which increases disability, morbidity, and consequently welfare and health care costs. In progressively older societies, reversing or slowing the aging process is a key priority, but effective measures are still lacking. However, several recent studies showing the therapeutic effect of the infusion of blood obtained from young mice into . . .
HIGH STANDARDS—A LAY OPINION.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Crosby WH:What to treat in Felty's syndrome
Journal: JAMA (1973)

Felty's syndrome originally was chronic rheumatoid arthritis, splenomegaly, and granulocytopenia. Other attributes have since come to be associated with it. Mild or moderate anemia and thrombocytopenia persist in most patients. A hypercellular marrow usually indicates that the low cell counts in the blood are provoking increased production. Of more serious concern is the ofttimes association of serious infection and sometimes indolent ulcers of the legs, buttocks, mouth, and even of the cornea. The combination of granulocytopenia and infection has evoked a natural assumption of cause and effect, but the assumption may not be valid. Although the leukocyte counts are low, plenty of "polys" reach the places where they are needed. An important factor in evaluating clinical importance of any granulocytopenia is the presence of polys outside the blood.<sup>1</sup>To look for them make a smear of nasal secretions. In Felty's syndrome the polys are there, outside the blood. The
Infantile Paralysis
Journal: JAMA (1935)

The author of this book is well known for his splendid contributions to the study of constitution and its relation to disease. Few other medical authors are better qualified by virtue of medical training and philosophic background to present to the intelligent lay public a short and comprehensive discussion of a subject so diverse in its manifestations. This is not an ordinary treatment of the subject but a scholarly and dispassionate presentation filled with useful scientific information about the disease and punctuated with enough philosophical reflection so that the reader not only learns but gains a certain amount of reassurance. The author has anticipated the numerous questions which the lay reader will want to know concerning the nature of the disease, its prevention, and what can be done after the disease is contracted. Any treatise written by this author without consideration of aspects of inherent susceptibility would be to the
Carbohydrates And Carbohydrate-Binding Proteins In The Nervous System
Authors: T. Jessell
Journal: Annual Review of Neuroscience (1990)

The brain's default mode network consists of discrete, bilateral and symmetrical cortical areas, in the medial and lateral parietal, medial prefrontal, and medial and lateral temporal cortices of the human, nonhuman primate, cat, and rodent brains. Its ...Read More
Abnormal Heart Rhythm in Patients with Leukemia Treated with Arsenic Trioxide
Journal: Annals of Internal Medicine (2000)

Summaries for Patients5 December 2000Abnormal Heart Rhythm in Patients with Leukemia Treated with Arsenic TrioxideSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-133-11-200012050-00007 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Acute promyelocytic leukemia (APL) is a cancer of the blood. Arsenic trioxide is effective in treating cases of APL that have not responded to other therapies. Abnormal heart rhythms are common in patients with arsenic poisoning, so there is concern that dangerous side effects might occur when arsenic is used to treat APL. A previous report found that heart rhythm abnormalities occurred in only 8 of 47 patients with leukemia receiving arsenic; none of these heart rhythms was life-threatening. However, another report described a patient with APL who ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Prolongation of the QT Interval and Ventricular Tachycardia in Patients Treated with Arsenic Trioxide for Acute Promyelocytic Leukemia.” It is in the 5 December 2000 issue of Annals of Internal Medicine (volume 133, pages 881-885). The authors are K Ohnishi, H Yoshida, K Shigeno, S Nakamura, S Fujisawa, K Naito, K Shinjo, Y Fujita, H Matsui, A Takeshita, S Sugiyama, H Satoh, H Terada, and R Ohno.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. Previousarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoProlongation of the QT Interval and Ventricular Tachycardia in Patients Treated with Arsenic Trioxide for Acute Promyelocytic Leukemia Kazunori Ohnishi , Hitoshi Yoshida , Kazuyuki Shigeno , Satoki Nakamura , Shinya Fujisawa , Kensuke Naito , Kaori Shinjo , Yota Fujita , Hirotaka Matsui , Akihiro Takeshita , Shiho Sugiyama , Hiroshi Satoh , Hajime Terada , and Ryuzo Ohno Metrics 5 December 2000Volume 133, Issue 11Page: I-59KeywordsArsenicBloodCancer treatmentDrugsElectrocardiographyHeartLongitudinal studiesPacemakersVeinsVentricular tachycardia ePublished: 5 December 2000 Issue Published: 5 December 2000 CopyrightCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Renal failure: the agony and the ecstasy
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MILK AND ALCOHOL IN HOSPITALS.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
High- and low-potency neuroleptics in elderly psychiatric patients
Authors: M. H. Branchey
Journal: JAMA (1978)

The efficacy and side effects of a low-potency neuroleptic, thioridazine hydrochloride, and those of a high-potency neuroleptic, fluphenazine hydrochloride, were compared in 30 elderly chronic schizophrenic patients. Through a crossover design, each patient received both drugs with an intervening washout period. Although both drugs produced a similar degree of improvement, their side effects differed. Fluphenazine caused slightly more extrapyramidal effects than thioridazine, though few occurred with use of either drug. Thioridazine caused weight gain, blood pressure decreases, and ECG changes. High-potency neuroleptic agents appear to be the drugs of choice for elderly schizophrenic patients. (<i>JAMA</i>239:1860-1862, 1978)
Accidental vaccinia.
Authors: D. C. Hutfield
Journal: BMJ (1968)

MEDICLJOUALthat is, high-speed-sawing, drilling, and sandpapering.The hardwoods would pro- vide greater frictional resistance and conse- quently more breakdown products.The analogy here is with tobacco or with coal.Tobacco is not per se carcinogenic, nor is coal, whereas tobacco smoke and coal tar distillates are.If this alternative suggestion holds true the recommendation by Dr. E.
Intrahepatic hepatitis C RNA levels do not correlate with degree of liver injury in patients with chronic hepatitis C
Authors: P McGuinness
Journal: Hepatology (1996)

The balance between a direct cytopathic effect by hepatitis C virus (HCV) and immune-mediated injury remains unclear. This report aims to test the following hypotheses: (1) that intrahepatic HCV load would correlate with the degree of liver injury; (2) that interferon alfa (IFN-α) would decrease intrahepatic HCV-RNA levels. Liver tissues (n = 56) were obtained from 47 patients with chronic HCV (9 before and after IFN-α therapy). Total RNA was isolated and quantitated for specific HCV RNA by dot-blot polymerase chain reaction (DB-PCR) using a standard curve created from synthetic HCV RNA of known titer to calculate actual RNA levels. A multivariate analysis was undertaken to determine the relationship of intrahepatic HCV-RNA levels with risk factors, length of HCV exposure, and histological injury scores. The confounding effect of HCV genotype was examined by direct sequencing of the NS5b region. Liver HCV RNA ranged from 102 to 3.1 × 107 molecules per microgram total liver RNA. The multiple regression analysis showed no effect of length of HCV exposure, risk factors, degree of bile duct damage, steatosis, or total Scheuer or Knodell score on RNA levels. No significant confounding effect of HCV genotype on the degree of liver injury was observed. However, genotype 1b had a significantly higher mean intrahepatic HCV-RNA load compared with the other genotypes detected. In the 9 patients who received IFN-α, treatment, 7 had no detectable HCV after treatment. This was associated with a significant decrease in intrahepatic HCV-RNA levels (7.57 ± 2.53 × 105 to 1.82 ± 1.80 × 103 molecules per microgram total liver RNA ± SEM, n = 9, P = .0005). These results do not directly support our hypothesis that increased intrahepatic HCV load is associated with more severe liver injury. Intrahepatic viral load appears to be significantly increased in patients with genotype lb. IFN-α treatment does significantly lower intrahepatic HCV load.