tbuckley/cabot-search huggingface dataset:
Lack of Effect of Drinking Water Chlorine on Lipid and Thyroid Metabolism in Healthy Humans
Authors: Robert G. Wones, Colleen C. Deck, Betsy Stadler, Suzanne Roark, Elizabeth Hogg, Lawrence A. Frohman
Journal: Environmental Health Perspectives (1993)

Animal studies and a single human epidemiological study have suggested that chlorine in drinking water may raise the level of blood cholesterol. The purpose of this study was to determine whether a 4-week exposure to drinking water chlorine (1.5 L per day) at a concentration of 20 ppm (ppm = mg/L) under controlled conditions would alter circulating parameters of lipid metabolism in healthy humans. Thirty men and thirty women each completed an 8-week protocol during which diet (600 mg cholesterol per day, 40% calories as fat) and other factors known to affect lipid metabolism were controlled. For the first 4 weeks of the protocol, all subjects consumed distilled water. For the second 4 weeks, half of the subjects were assigned randomly to drink 1.5 L per day of chlorinated water (20 ppm), while the others continued drinking distilled water. Four blood samples were collected from each subject at the end of each 4-week study period. Compared to the control group, those subjects given chlorine showed no significant changes in total plasma cholesterol, triglycerides, HDL-cholesterol, LDL-cholesterol, or apolipoproteins A1, A2, or B. There was a trend toward low serum thyroxine and triiodothyronine levels in men given chlorine, though thyroid-stimulating hormone levels were unchanged. This trend, if real, was not clinically significant. Thus, short-term exposure to chlorinated drinking water at 20 ppm appears to have no significant impact on parameters of lipid or thyroid metabolism in healthy humans.
Contents
Authors: Katrin Wacker, Keith Baratz, William Bourne, Sanjay Patel, Eric Hwang, Claudia Perez-Straziota, Sang Kim, Marcony Santhiago, J Randleman, Stephen Klyce, Yu Sawada, Makoto Araie, Hitomi Shibata, Makoto Ishikawa, Toyoto Iwata, Takeshi Yoshitomi
Journal: Ophthalmology (2018)
Hormonal Regulation of Cytosolic Free Calcium and Its Functional Consequences: The GH-Cell Model
Authors: Armen H. Tashjian
Journal: Environmental Health Perspectives (1990)

Use of clonal strains of prolactin (PRL)- and growth hormone-producing rat pituitary cells has proven informative in elucidating a number of the early biochemical, ionic, and secretory events regulated by the hypothalamic tripeptide, thyrotropin-releasing hormone (TRH). TRH causes biphasic changes in the concentration of cytosolic free calcium [( Ca2+]i) in GH4C1 cells and biphasic changes in hormone secretion. Early changes occur on a msecond to second scale and late changes, on a time scale of minutes. Although increases in [Ca2+]i are essential for enhanced secretion, at least in the case of the rapid initial phase, the TRH-induced increase in [Ca2+]i is necessary, but not sufficient to enhance secretion. A co-mediator with calcium appears to be diacylglycerol. The majority of the calcium involved in the early phase of rise in [Ca2+]i induced by TRH is derived from intracellular sources, while essentially all of the calcium rise observed in the late phase is derived from extracellular calcium entering the cell through both voltage-dependent and voltage-independent conductances. Because TRH causes an elevation of inositol(1,4,5) trisphosphate [Ins(1,4,5)P3] within seconds, but not mseconds, further studies are required before it can be concluded unequivocally that Ins(1,4,5)P3 is the sole mediator of the rapid phase of rise in [Ca2+]i induced by TRH in GH-cells.(ABSTRACT TRUNCATED AT 250 WORDS)
The Clinical Use of Diuretics
Authors: Howard S. Frazier, Henry Yager
Journal: New England Journal of Medicine (1973)

Adjuvant Therapy — Spironolactone and TriamtereneIf the underlying disease progresses, it may eventually become impossible to control the formation of edema on a program that includes tolerable levels of salt restriction and administration of benzothiadiazides. One explanation for the development of the thiazide-fast state is an increase in sodium reabsorption at sites in the nephron both proximal and distal to those where thiazides act, including the sites whose activity is enhanced by aldosterone. Under these circumstances, renewed diuresis will often result from the addition of an agent such as spironolactone or triamterene to the regimen. Substitution of one of . . .
Incorrect Row Labels in Table 2
Authors: Nikhil Dhurandhar, Diana Thomas
Journal: JAMA (2015)

Leticia Nogueira, MPH, PhD; Claudia Foerster, PhD; John Groopman, PhD; Patricia Egner, MS; Jill Koshiol, PhD; Catterina Ferreccio, MD, MPH; for the Gallbladder Cancer Chile Working Group
Osteopontin drives HBV replication and HBV-driven fibrogenesis and represents a novel therapeutic target to achieve functional cure in chronic hepatitis B
Authors: Sandra Phillips, Sameer Mistry, Jason Coombes, Tanya Hadzhiolova, Ewald Doornebal, Nicola Harris, Elena Palma, Antonio Riva, Slava Pavlova, Marieta Simonova, Luca Urbani, Lola Ajayi, Dipa Natarajan, Krum Katzarov, Krishna Menon, Andreas Prachalias, Parthi Srinivasan, Nigel Heaton, Michail Pizanias, Ane Zamalloa, Melissa Preziosi, Yoh Zen, Rosa Miquel, Corina Cotoi, Maesha Deheragoda, Caroline Robinson, Patrick Kennedy, Upkar Gill, Thiago A Pereira, Fausto Edmundo Pereira, Roger Williams, Wing Syn, Shilpa Chokshi
Journal: Journal of Hepatology (2020)
"PROBLEM OF THE NARCOTIC ADDICT"
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
HOUT-11. EXTENSIVE BRAINSTEM INFILTRATION, NOT MASS EFFECT, IS A COMMON FEATURE OF END-STAGE CEREBRAL GLIOBLASTOMAS
Authors: Michael Drumm, Karan Dixit, Sean Grimm, Priya Kumthekar, Rimas Lukas, Jeffrey Raizer, Kwok-Ling Kam, Matthew McCord, Sean Sachdev, Timothy Kruser, Alicia Steffens, Rodrigo Javier, Kathleen McCortney, Craig Horbinski
Journal: Neuro-Oncology (2019)

Abstract BACKGROUND Progress in extending the survival of glioblastoma (GBM) patients has been slow, suggesting that preclinical and clinical trial approaches may not fully take into account the nature of this cancer. A better understanding of why GBM patient survival remains poor is critical to developing new strategies. Postmortem studies on GBM can shed light on how GBM spreads and how GBM patients are dying. METHODS The brains of 25 GBM patients were autopsied and examined for gross and microscopic abnormalities. Clinical-pathologic correlations were accomplished through detailed chart reviews. Data were compared with older published autopsy GBM studies that predated the use of concurrent radiation and temozolomide (RT/TMZ). RESULTS In pre-RT/TMZ GBM autopsy series, mass effect was observed in 72% of brains, with herniation in 50% of cases. Extensive infiltration of tumor into the brainstem occurred in only 21% of those older cases. In the current series, only 7 of 25 (28%) GBMs showed mass effect (P=0.0004), and none (0%) showed herniation (P&lt; 0.0001). However, extensive GBM infiltration through the cerebral peduncles, into the brainstem, was present in 17 cases (68%, P&lt; 0.0001), with accompanying destruction of the brainstem and white matter tracts. There was a direct correlation between longer patient survival and the presence of brainstem infiltration (P=0.001). CONCLUSIONS With improving care, severe mass effect is less common in GBM patients today, whereas life-threatening brainstem invasion is now more frequent. This has major implications regarding preclinical GBM models, as well as the design of clinical trials aimed at further improving patient survival.
"THE WILL TO BELIEVE"
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Noncontraceptive hormones and rheumatoid arthritis in perimenopausal and postmenopausal women
Authors: J. P. Vandenbroucke
Journal: JAMA (1986)

The use of noncontraceptive hormones<i>before</i>onset of joint disease was compared between 490 perimenopausal and postmenopausal women with rheumatoid arthritis and a control group of 659 women with soft-tissue rheumatologic disorders and/or osteoarthritis. Both groups were sampled randomly from the attendees of five rheumatologic clinics. A negative association was found between the onset of rheumatoid arthritis and the previous use of noncontraceptive hormones (odds ratio, 0.32; 95% confidence interval, 0.16 to 0.64). This association persisted on univariate and multivariate control of potentially confounding variables and on subgroup analysis. The protective effect of oral contraceptives on the development of rheumatoid arthritis was confirmed. (<i>JAMA</i>1986;255:1299-1303)
Possible naproxen-induced relapse of subacute cutaneous lupus erythematosus
Authors: A. Parodi
Journal: JAMA (1992)

<h3>To the Editor.</h3> —A 59-year-old woman had been diagnosed as having subacute cutaneous lupus erythematosus (SCLE) 2 years previously and was given chloroquine and prednisone (250 mg/d), which cleared her skin lesions. In such a quiescent state, she began taking calcitonin and 250 to 500 mg per day of naproxen sodium. One month later, in spring, without any recreational or occupational sun exposure, typical SCLE lesions developed on her upper chest and forearms (Figure). The patient was given azathioprine (50 mg/d) and hydroxychloroquine sulfate (500 mg/d) without any benefit. Azathioprine was discontinued 15 days later and naproxen 1 month later. Only then did the SCLE lesions clear. Results of routine laboratory tests were normal or negative, but her creatinine level was high (190 μmol/L; normal, &lt;100 μmol/L), and creatinine clearance was low (0.44 mL/s; normal, 1.24 to 2.08 mL/s). Before naproxen treatment she had anti-SS-A/Ro antibodies at 1:4 titer that
Pathology and Morbid Anatomy.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Farsightedness-Reply
Authors: Dale E. Hammerschmidt
Journal: JAMA (1985)

<h3>In Reply.—</h3> I thank Drs Smith and Krogh for their kind comments; I confess that I have occasionally resorted to Dr Caccamise's solution (and more often have wished that I had done so!). The rule I presented doesn't require a calculator with fresh batteries; the calculations were presented just to show the basis for my simple guideline: <h3>NINE DOUBLE-SPACED LINES OF FIFTY CHARACTERS WILL ALMOST ALWAYS BE LEGIBLE; EXCEED THAT ONLY AT RISK OF LOSS OF AUDIENCE.</h3> The corollary mentioned by Drs Smith and Krogh is a useful one, though. In glancing through the slides currently (dis)arrayed on my desk, I find it tough to read the ones with more than ten or 12 lines at normal reading distance. I wasn't familiar with the "rule of eight," as stated by Dr Smith. I did pull out my calculator to check and found that—if the guidelines to which he alludes are
Habañera
Authors: Edythe Haendel Schwartz
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SMALLPOX IN GREAT BRITAIN
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Section 30.—Bursitis
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hormonal Treatment of Cancer
Authors: Ira T. Nathanson, Rita M. Kelley
Journal: New England Journal of Medicine (1952)

Carcinoma of the Prostate GlandThe treatment of cancer of the prostate gland by attacking the endocrine balance of the patient rests on firmer physiologic grounds, is better understood and yields more predictable results than the hormonal treatment of mammary carcinoma. The past six years have permitted a relatively long-term follow-up of the first patients treated by these methods, as well as an opportunity to study large series of cases. These observations have contributed much to the establishment of a rational basis for the palliative treatment of advanced prostatic cancer.4–9, 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 The concepts are based primarily on the fundamental work of . . .
Plural, Not Pleural
Authors: Michael Natalino, Richert Goyette, Loren Owensby, Ronald Rubin
Journal: JAMA (1978)

hepatomegaly, and jaundice.This diagnosis was confirmed by a liver biopsy specimen and hepatic venogra- phy.3Sickle cell anemia has been re¬ ported as causing Budd-Chiari syn¬ drome."Our patient had only 38% hemoglobin S on hemoglobin electro- phoresis and manifested no anemia.Further, no evidence of sickling was seen in the biopsy tissue.Therefore, sickling did not appear to play a role in our patient.Further hématologie evaluation, including measurement of antithrombin III levels, was within normal limits.We propose that the development of the Budd-Chiari syndrome in our patient was the result of extrinsic compression on hepatic veins by inflammation and edema from sar- coid granulomas, leading to narrow¬ ing of venous channels, venous stasis, and subsequent thrombosis.No other apparent cause for hepatic vein occlu¬ sion was demonstrable by history, laboratory studies, or anatomic find¬ ings at laparotomy.The findings in our patient indicate that the Budd- Chiari syndrome can complicate sar- coid involvement of the liver.
Medical Research Helps US Olympic Athletes Improve on Swimming Records
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal