tbuckley/cabot-search huggingface dataset:
USE OF ADHESIVE PLASTER IN CLOSING ABDOMINAL INCISIONS
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Phase II study of atorvastatin in combination with radiotherapy and temozolomide In patients with glioblastoma (ART): interim analysis report
Authors: A.K. Altwairgi, W. Alghareeb, F. Alnajjar, E. Alsaeed, A. Balbaid, H. Alhussain, S. Aldanan, Y. Orz, A. Lari, A. Alsharm
Journal: Annals of Oncology (2016)
Numeracy
Authors: Lisa M. Schwartz
Journal: Annals of Internal Medicine (1998)

Letters1 May 1998NumeracyLisa M. Schwartz, MD, MS and Steven Woloshin, MD, MSLisa M. Schwartz, MD, MSVeterans Affairs Medical Center; White River Junction, VT 05009.Search for more papers by this author and Steven Woloshin, MD, MSVeterans Affairs Medical Center; White River Junction, VT 05009.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-9-199805010-00030 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We are pleased by Dr. Blank's interest in our study. We agree that the issue of physician numeracy merits attention. We do not know of any studies specifically assessing physician's facility with numbers or ability to communicate quantitative information about disease risk or treatment benefit. Although higher levels of educational attainment are related to better quantitative ability [1], even highly educated people may have difficulty with basic numerical concepts. In our study, for example, only 10 of 31 women with postgraduate degrees answered all three numeracy questions correctly. In the National Adult Literacy Survey, 11% of respondents who ...References1. Kirsch I, Jungeblut A, Jenkins L, Kolstad A. Adult Literacy in America. Washington, DC: National Center for Education Statistics; 1993. Google Scholar Author, Article, and Disclosure InformationAuthors: Lisa M. Schwartz, MD, MS; Steven Woloshin, MD, MSAffiliations: Veterans Affairs Medical Center; White River Junction, VT 05009. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1998Volume 128, Issue 9Page: 783KeywordsForecastingGraduate medical educationLiteracyNumeracyRivers ePublished: 15 August 2000 Issue Published: 1 May 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
The productivity costs of providing or withholding treatment
Authors: G. W. Anstadt
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ophthalmic Operations as Practiced on Animals' Eyes.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE TESTIMONIAL AND THE MEDICAL PRESS.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Analysts differ over implications of more hospital closings than openings since 1987
Authors: E. Friedman
Journal: JAMA (1990)

SIX HUNDRED ninety-eight hospitals closed from 1980 through 1989, according to the American Hospital Association (AHA). This is not a simple case of a steadily diminishing number of US hospitals. A small number of facilities open each year, and in the early part of the decade, more hospitals opened than closed. However, since 1987, closings have been more common than openings. Between 1980 and 1989, of the 698 hospitals that closed, 508 were "community" hospitals (that is, general acutecare facilities) and 190 were "noncommunity" (specialty or other non—acutecare facilities). Of the community hospitals, 256 were urban and 252 were rural; 43.1% were not-for-profit, 37.4% were for-profit, and 19.5% were nonfederal government facilities. They tended to be small; 81.1% had fewer than 100 beds, and 54.1% had fewer than 50 beds. <h3>Every State</h3> The largest numbers of community hospitals closed in Texas (95), California (52), New York (37), Illinois (24), Michigan
Graphs showing risks help communication
Journal: BMJ (1999)

Decision aids do improve patients' decision makingTrials of aids to help patients consider the benefits and harms of medical treatments show that they improve patients' knowledge, comfort, and participation in decision making without increasing anxiety.The systematic review by O'Connor et al (p 731) also found that decision aids had little effect on satisfaction and an inconsistent effect on patients' decisions.The trials of decision aids focused on hormone therapy, circumcision, screening for cancer and genetic disorders, and treatments for prostate cancer, breast cancer, and heart disease.The results consistently showed that decision aids were better than usual practice.
Awakening
Authors: Maureen O'Dea
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TWO CASES OF HYPERTROPHIC CIRRHOSIS OF THE LIVER IN THE SAME FAMILY
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correspondence
Authors: C.M. Ridley
Journal: British Journal of Dermatology (1982)

Journal Article Correspondence Get access C.M. Ridley C.M. Ridley Whittington Hospital, London N19 5NF Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 106, Issue 3, 1 March 1982, Page 373, https://doi.org/10.1111/j.1365-2133.1982.tb01741.x Published: 01 March 1982
Clinical Epidemiology
Authors: George L. Fite
Journal: JAMA (1966)

Paul's presentation of epidemiology is a cocktail to be taken before beginning investigation in the medical sciences. Although a straightforward treatise, it does not handle epidemiology as if it were methodology. Epidemiology develops as an attitude toward learning, and application of intelligence to the search. Paul's epidemiology is bound by no techniques, nor is it confined by tight definitions. Even in the samples of diseases given, the sense of freedom is retained, and the effect is to endow epidemiology with a flavor and character it may not always exhibit in practice. The current revision has naturally taken notice of events intervening since the 1958 edition. Fortunately, even with the remarkable additions to knowledge in many fields, the epidemiological approach to disease has changed little, if at all, in this time. So, Dr. Paul's epidemiology is as current as it has always been; only the examples to which he refers needed
Retraction of paper on maternal diabetes
Journal: BMJ (2003)

composition, ranging from lone consultant nurses to multiprofessional teams, and in their working patterns and activity. 9Some outreach teams follow up patients as described in our study, whereas others attend once patients show early warning criteria (see box).The results of our study are therefore not transferable. LimitationsOur study design could have confounded the results; before and after studies are retrospective, therefore variables cannot be controlled.In our study a concomitant innovation in the hospital could have produced the same results.Patients were, however, discharged from critical care to different areas of the hospital, and at the time of the study there was no other innovation that could have had an effect on patients.The median predicted probability of mortality was 16.1% compared with 20.4% in the historical cohort.Although this was not statistically significant, part or all of the effect seen might be explained by this difference.Several authors have, however, questioned the ability of the tool to predict mortality and it is currently the subject of further investigation by the Intensive Care National Audit Research Centre.The tool therefore might explain some of the variation in outcome but not all of it.Before and after studies may also show a lack of equivalence between comparators, and interventions may vary.Both our groups had similar risk factors.These were chosen for their association with mortality and readmission and seemed to be appropriate for the purposes of our study.The interventions undertaken by team members did vary, possibly owing to length of time available for the intervention or the manner in which the intervention was undertaken by the individual and on a particular day.It is unlikely, however, that one individual or one intervention can be associated with the findings.Rather, the combined effect of the interventions seems to have had a beneficial effect on outcomes.The use of routine audit data, rather than specific data collected for research purposes, may also have produced erroneous results.The database was examined on a random basis for reliability and seemed sound.If the innovation described here had not been introduced so hastily, owing to political imperative, we could have conducted a prospective randomised controlled trial.Evidence for innovation in service delivery will always be prone to limitations where evaluation is not undertaken before wholesale application.Policy makers should consider testing health service innovation using cluster randomised controlled trials with the hospital as the sampling unit.An example of this is the medical early response intervention and therapy study currently being undertaken in Australia to assess medical emergency teams. 10
BOOK REVIEWS
Authors: J. B. REDMOND
Journal: JNCI Journal of the National Cancer Institute (1992)

Journal Article BOOK REVIEWS Get access A Word Book in Oncology and Hematology—Including Terminology of AIDS Sheila B. Sloane . Philadelphia : B. C. Decker , 1992 . 280 pp., illus. $24.95 JULIA B. REDMOND JULIA B. REDMOND Management Analyst and Book Review Coordinator Journal of the National Cancer InstituteBldg.82, Rm.227 903 Old Georgetown Rd. Bethesda, MD 20814 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 84, Issue 20, 21 October 1992, Page 1598, https://doi.org/10.1093/jnci/84.20.1598 Published: 21 October 1992
Objective pathological diagnosis of coal worker's pneumoconiosis
Authors: E. R. Fisher
Journal: JAMA (1981)

Pertinent pathological features of lungs obtained at autopsies from 99 coal miners were compared with those observed in the lungs of 268 male town dwellers of comparable age who were not occupationally related to the coal mining or other industries at risk for development of pneumoconiosis. The degree of anthracotic pigment deposition and severity of type of pigmented lesion with its accompanying reticulum fiber formation and fibrosis were significantly greater in lungs of miners. There was a high degree of overlap in degrees of pigment deposition, particularly those quantitated as grades 1 and 2 and in lesions regarded as types 1 and 2. The greatest divergence was observed for prevalence of nodular pulmonary lesions (type 4). There was also a considerable divergence in the type 3 alteration characterized by nonnodular aggregates of carbon-laden macrophages accompanied by minimal reactive fibrosis. It appears that an objective pathological diagnosis of coal workers' pneumoconiosis (CWP) can be rendered only by the demonstration of type 4 lesions. Approximately 25% of coal miners exhibited unequivocal features of CWP. No significant differences concerning incidence or types of emphysema or frequency of chronic cor pulmonale were encountered between the two populations. (<i>JAMA</i>1981;245:1829-1834)
Genomic and phenotypic evidence for prostate cancer osteomimicry in circulating tumor cells from men with metastatic castration resistant prostate cancer (mCRPC) treated with radium-223.
Authors: Andrew J. Armstrong, Santosh Gupta, Patrick Healy, Gabor Kemeny, Lauren Beth Leith, Michael Zalutsky, Charles Spritzer, Catrin Davies, Colin Rothwell, Katie Ware, Jason Somarelli, Kris Wood, Thomas Ribar, Drew Gerber, Monika Anand, Susan Halabi, Simon Gregory, Daniel J. George
Journal: Journal of Clinical Oncology (2018)

5029 Background: Radium-223 is a targeted alpha-therapy that improves survival in men with mCRPC. The biologic basis for radium-223 efficacy is not completely understood. We hypothesized that PC osteomimicry, a form of epithelial plasticity leading to an osteoblastic phenotype, may contribute to the intralesional deposition of radium-223 and subsequent irradiation of the tumor microenvironment. Methods: We conducted a pharmacodynamic study (NCT02204943) of radium-223 in men with bone metastatic CRPC to investigate genomic and phenotypic alterations in circulating tumor cells (CTCs), ctDNA, and metastases. Prior to and 3 & 6 months after radium, we collected liquid and metastatic biopsies including CTCs for phenotypic characterization and CTC/ctDNA genomic analysis. The primary objective was to describe the prevalence of CTC bone alkaline phosphatase (BAP) over time. We measured radium-223 decay products in tumor and surrounding normal bone during treatment. Results: We enrolled 20 men with heavily pre-treated symptomatic bone predominant mCRPC and treated with radium-223 over a median of 6 doses; 55% had elevated serum BAP. PFS was 5.5 mo; OS was 13.3 mo; 13% had unfavorable (≥5) to favorable ( < 5) Cellsearch CTC conversion; 5% had ≥30% PSA decline. We found evidence of persistent BAP+CTCs in the majority of men over time during radium-223 therapy despite serum BAP normalization in 53% of men. We identified genomic gain of key osteomimicry regions in CTC DNA, including gains of BAP, osteopontin, and OB-cadherin. We observed greater gamma emission from radium-223 from tumor biopsies than adjacent normal bone. CTC DNA and matched ctDNA studies suggested persistence of aggressive genomic alterations such as AR, FOXA1, and MYC/N-MYC gain and PTEN, GRHL2, FGFR2, and BRCA1 loss. We established several prostate CTC cultures exhibiting evidence of epithelial plasticity and BAP expression. Conclusions: Osteomimicry may contribute to the uptake of Radium-223 within bone metastases and may thereby enhance the therapeutic benefit of radium-223. We found genomic and phenotypic evidence of osteomimicry in CTCs from men with mCRPC. Clinical trial information: NCT02204943.
Significance of anti-HBx antibodies in hepatitis B virus infection
Authors: M Levrero
Journal: Hepatology (1991)

Serological responses to hepatitis B virus–X determinants have been noted in human sera, but conflicting findings concerning the correlation of anti-HBx antibodies with different stages of hepatitis B virus infection or pathological sequelae have been reported. Using an adenovirus-based eukaryotic vector, the 17 kD X protein was efficiently expressed in 293 cells. Cellular extracts containing the eukaryotic X protein have been used to screen for anti-HBx antibodies by immunoblot analysis in a large panel of sera from patients affected by hepatitis B virus chronic hepatitis, hepatocellular carcinoma and acute viral hepatitis. Sera from 32 of 171 (19%) chronic hepatitis B virus patients were positive for anti-HBx antibodies. Only one of thirty-two (3%) HBsAg-negative, anti-HBs/anti-HBc—positive chronic hepatitis serum was anti-HBx positive. Very few sera from primary hepatocellular carcinoma patients showed positivity for anti-HBx (8 of 149 or 5%). Anti-HBx were also detected in 8 of 48 (17%) acute viral hepatitis patients. In the four cases that were followed up weekly, anti-HBx anti-bodies appeared 3 to 4 wk after the onset of the clinical signs. To compare the X protein expressed in eukaryotic and prokaryotic cells as a substrate for anti-HBx antibody detection, 171 sera were screened with HBx fusion proteins expressed in Escherichia coli. The prokaryotic cell extract test seems to be more sensitive. During the chronic phase of hepatitis B virus infection, the presence of anti-HBx antibodies detected with the eukaryotic cell extract correlates with the presence of well-established markers of ongoing viral replication: serum hepatitis B virus-DNA (p < 0.001) and intrahepatic HBcAg expression (p < 0.001). (HEPATOLOGY 1991;13:143—149).