tbuckley/cabot-search huggingface dataset:
Charities and Correction.—
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Somatic Cells as Indicators of Germinal Mutations in the Mouse
Authors: Liane B. Russell
Journal: Environmental Health Perspectives (1978)

In attempts to find a prescreen for mutagens that may induce heritable mutations in mammals, an in vivo somatic mutation test has been developed in the mouse that uses a localized gene product (hair pigment), is relatively fast and cheap, and gives results that have some predictive value for point mutation induction in spermatogonia. Embryos heterozygous at specific coat color loci are exposed to the presumptive mutagen, and 3 weeks later the fur is observed for spots of altered color. It is possible to distinguish spots resulting from expression of the recessive (RS's) from spots having various other causes. In tests with seven compounds, mutation rates per locus and unit dose have been calculated on the assumption that 175 cells are at risk per 10¼-day embryo (a number derived from distribution of spot proportions). These rates are found to be roughly parallel to, but uniformly higher than spermatogonial point-mutation rates for the same seven compounds. The higher somatic rates are presumably due to the fact that RS's can result from several genetic mechanisms besides point mutations. The spot test, which has not to date given any false negatives, may thus be considered a useful in vivo prescreen for heritable germinal mutations in mammals.
Public Health
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Note from the editors: Special issue on advanced diagnostics to inform public health policy
Journal: Eurosurveillance (2018)

Preview this article: Note from the editors: Special issue on advanced diagnostics to inform public health policy, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/23/50/eurosurv-23-50-1-1.gif
VENEREAL DISEASES AND THE PUBLIC HEALTH.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fetal Loss Associated With Excess Thyroid Hormone Exposure—Reply
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Use of <i>TMPRSS2-ERG</i> gene rearrangement and quantitative ERG expression to predict clinical recurrence after radical prostatectomy.
Authors: E. A. Klein, S. M. Falzarano, T. Maddala, D. Cherbavaz, W. F. Novotny, C. Millward, C. Magi-Galluzzi
Journal: Journal of Clinical Oncology (2011)

36 Background: The association of TMPRSS2-ERG fusions and ERG expression in prostate cancer (PC) with adverse clinical outcomes has been controversial, with mixed results in the literature. We conducted a study to test whether tumor-derived gene expression profiles, including the presence of TMPRSS2-ERG fusions and ERG gene expression, are associated with clinical recurrence (cR) after radical prostatectomy (RP). Methods: All patients with clinical stage T1/T2 prostate cancer treated with RP at CC from 1987 to 2004 were identified (n∼f2,600). A cohort sampling design was used to select 127 patients with cR and 374 patients without cR after RP. For each patient a primary Gleason pattern (GP) sample, secondary (or highest) GP sample, and an adjacent nontumor tissue sample were evaluated. Surgical Gleason Score (GS) and clinical data were centrally reviewed. RNA was extracted from 6 manually dissected 10 μ m formalin-fixed paraffin-embedded sections obtained from RP specimens and expression of TMPRSS2-ERGa, TMPRSS2-ERGb, ERG and reference genes were quantified using RT-PCR. Times to cR, PSA recurrence, and PC death were analyzed using Cox PH regression. Results: Blocks from 441 patients were evaluable. Median F/U was 5.8 years. Patients were mostly Caucasian (83%), clinical stage T1 (66%), had baseline PSA &lt;10 ng/mL (82%), and had surgical Gleason score ≤7 (87%). 848 tumor samples and 410 non-tumor samples were assessed. TMPRSS2-ERGa and/or TMPRSS2-ERGb fusions were present in 51.8% of tumor samples and 7.5% of non-tumor samples. There was 89% concordance (95% CI: 86%, 92%) for TMPRSS2-ERG fusion status between the 2 tumor samples for each patient. High ERG expression was strongly associated with the presence of TMPRSS2-ERG fusions (p &lt;0.01). We did not find an association between TMPRSS2-ERG a/b gene rearrangement or ERG expression with cR, PSA recurrence, PC death, or surgical GS (p &gt; 0.2). Conclusions: This study was notable for the large number of cR events, use of a standardized quantitative assay, and rigorous central review of pathology and clinical data. We did not find an association of TMPRSS2-ERG gene rearrangements or ERG expression with aggressiveness of prostate cancer post RP. [Table: see text]
Therapy for Hypercholesterolemia; Standardization of Cholesterol Measurements
Authors: Joel I. Hamburger
Journal: JAMA (1990)

<h3>To the Editor.—</h3> As Drs Blum and Levy<sup>1</sup>indicate, cholestyramine and colestipol are insoluble powders that lower cholesterol levels by interrupting the enterohepatic circulation of bile acids. They are safe and effective agents, but there is one important contraindication to their use, ie, dependency on exogenous thyroid hormone to correct hypothyroidism. This is not news to thyroidologists. Indeed, a 1969 report in<i>JAMA</i>clearly described this problem.<sup>2</sup>However, our recent experience indicates that the information has not received adequate attention in the medical literature. In fact, this potential complication was not mentioned by Drs Blum and Levy. In the past 18 months, we have seen 11 patients (Table) who required thyroid hormone to correct or prevent hypothyroidism (7 with Hashimoto's thyroiditis, 3 who had previously been treated with radioactive iodine for hyperthyroidism, and 1 who had been treated surgically and with radioactive iodine for thyroid cancer), who
Repository of Biological Specimens From Homosexual Men
Journal: JNCI Journal of the National Cancer Institute (1985)

Journal Article Repository of Biological Specimens From Homosexual Men Get access JNCI: Journal of the National Cancer Institute, Volume 75, Issue 2, August 1985, Page 395, https://doi.org/10.1093/jnci/75.2.395 Published: 01 August 1985
Clinical Assessment of Auditory Dysfunction
Authors: W. G. Thomas
Journal: Environmental Health Perspectives (1982)

Many drugs, chemical substances and agents are potentially toxic to the human auditory system. The extent of toxicity depends on numerous factors. With few exceptions, toxicity in the auditory system affects various organs or cells within the cochlea or vestibular system, with brain stem and other central nervous system involvement reported with some chemicals and agents. This ototoxicity usually presents as a decrease in auditory sensitivity, tinnitus and/or vertigo or loss of balance. Classical and newer audiological techniques used in clinical assessment are beneficial in specifying the site of lesion in the cochlea, although auditory test results, themselves, give little information regarding possible pathology or etiology within the cochlea. Typically,, ototoxicity results in high frequency hearing loss, progressive as a function of frequency, usually accompanied by tinnitus and occasionally by vertigo or loss of balance. Auditory testing protocols are necessary to document this loss in auditory function.
Venereal disease vs Bowen's disease
Authors: N. G. McLetchie
Journal: JAMA (1977)

We read Dr Letchie's letter with interest and wish he had supported his opinion "that most people with a knowledge of the histopathology of viral infections... would opt for Bowen's disease being a viral infection" with literary references or other objective data. To our knowledge, while a relation of Bowen's disease to arsenic intake has been supported, no convincing evidence for viral etiology has been adduced.<sup>1</sup>The one instance in which generalized human virus warts are definitely associated with the development of carcinomas is epidermodysplasia verruciformis, and the resulting invasive squamous cell carcinomas do not usually have a bowenoid phase.<sup>1</sup> Dr McLetchie seems to have missed the simple message we tried to convey. After many decades during which viral warts of the genitalia have been known to have the characteristic orderly histologic structure of "condyloma acuminatum," there is now a rash of lesions that clinically are condylomata
The Making of an Automobilist.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
International Comments
Journal: JAMA (1974)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
FRANCE
Journal: JAMA (1961)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Craniopharyngioma in two siblings
Authors: J. R. Vargas
Journal: JAMA (1981)

WE DESCRIBE two siblings, both with gradual development of symptoms of diabetes insipidus and panhypopituitarism, in whom craniopharyngiomas were found. <h3>Report of Cases</h3><h3>Case 1.—</h3> A boy who had been treated intermittently for diabetes insipidus for seven years and for panhypopituitarism for five years came under our care in 1974 at age 16 years. He was prepubertal, weighed 20.6 kg, was 140 cm tall, and had grown 3 cm in height during the preceding five years. Physical examination revealed bitemporal hemianopsia and bilateral nasal optic disc atrophy. The neurological examination findings were normal. Simultaneous urine and plasma osmolalities were 207 and 295 mOsm/kg, respectively. The EEG revealed occasional focal slowing in the bitemporal region. Endocrine studies indicated panhypopituitarism (Table). Radiological studies revealed generalized enlargement of the sella turcica with ballooned floor and erosion of the dorsum sellae. A pneumoencephalogram demonstrated an intrasellar mass with 7 mm of suprasellar extension. The
Spleen in myeloproliferative neoplasms
Authors: Giovanni Barosi
Journal: HemaSphere (2018)

IRCCS Policlinico S. Matteo Foundation, Pavia, Italy This is an open access Abstract Book distributed under the Attribution-NonCommercial-NoDerivs (CCBY-NC-ND), which allows third parties to download the abstracts and share them with others as long as they credit the author and the abstract book, but they cannot change the content in any way or use them commercially. http://creativecommons.org/licenses/by-nc-nd/4.0
Hypoparathyroidism and pregnancy. Treatment with calcitriol
Authors: A. Sadeghi-Nejad
Journal: JAMA (1980)

Calcitriol was used successfully to treat a patient with hypoparathyroidism during pregnancy. Increasing dosages of calcitriol were needed during the last trimester with a prompt decrease in the requirement after delivery. The dosage changes appear to mirror the pattern of endogenous synthesis of calcitriol in normal pregnant women. (<i>JAMA</i>243:254-255, 1980)
Pregnancy Tests
Authors: Stanley L. Robbins
Journal: New England Journal of Medicine (1948)

IT IS remarkable that a condition so essentially benign and self-limited as pregnancy, which must inevitably become obvious in the due course of time, has evoked so much interest in its early diagnosis. Despite the fact that in all but possible ectopic pregnancies no great need for speed in diagnosis truly exists, constant emphasis has been attached to the time required for the performance of a pregnancy test. As a result, although the first modern pregnancy test, the Aschheim-Zondek, which was described approximately twenty years ago, has never been surpassed for accuracy, new procedures have appeared each year, designed essentially . . .
Error in Table.
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The value of coronary bypass surgery compared with medical therapy
Authors: J. W. Hurst
Journal: JAMA (1989)

I have followed the work of the clinical investigators at Duke University<sup>1</sup>for the last 15 years as they carefully observed and treated patients with atherosclerotic coronary heart disease. Whereas many experts demand randomized trials to determine the value of a specific form of treatment, our Duke friends have emphasized that observational studies are also useful in arriving at a conclusion regarding the value of a specific type of treatment. Accordingly, they studied and followed up 5809 patients who either had coronary bypass surgery or were treated medically. I, too, believe that excellent observational studies by superb clinical investigators can teach us all a great deal. So, I wish to compliment the large number of investigators who assisted in the study that is reported in this issue of<i>JAMA</i>.<sup>1</sup> During the early 1970s, bypass surgery was restricted to patients who were disabled from angina pectoris despite intensive medical
Early primary biliary cirrhosis: Just delayed or different?
Authors: K Lindor
Journal: Hepatology (1997)

biopsy specimens in 16 of 35 patients.Of note, despite using to be more optimistic about vaccines or immunoadjuvant therapies designed to elicit host anti-HCV specific CTL.vaccinia vectors encoding genotype 1a HCV epitopes in their assays, anti-HCV specific CTL activity was detected in 3 of 9 patients with genotype 1b and 3 of 9 patients with non-DWAIN L. THIELE, M.D. type 1 genotypes as well as in 10 of 17 patients with genotype Liver Unit/Internal Medicine 1a or mixed genotype 1a and 2a infections.Thus despite UT Southwestern Medical Center at Dallas concerns that CTL responses might be underestimated be-Dallas, TX cause of sequence differences between in vivo viral antigens stimulating the response and the recombinant genotype 1a REFERENCES antigens used in in vitro research assays, sufficient CTL re-1.Chisari FV, Ferrari C. Hepatitis B virus immunopathology.Springer sponses appear to be directed against conserved epitopes Semin Immunopathol 1995;17:261-281.derived from the HCV core protein to allow detection in 2. Brook MG, Karayiannis P, Thomas HC. Which patients with chronic hepatitis B virus infection will respond to a-interferon therapy?A statis-such assays of CTL responses in patients with non-type 1a tical analysis of predictive factors.