tbuckley/cabot-search huggingface dataset:
<i>Circulation:</i> Clinical Summaries
Journal: Circulation (2013)

Incident Atrial Fibrillation and Risk of End-Stage Renal Disease in Adults With Chronic Kidney DiseaseAtrial fibrillation frequently occurs among patients with chronic kidney disease (CKD) and is associated with adverse outcomes.In this study, we evaluated the association of incident atrial fibrillation with progression of CKD to end-stage renal disease, defined as the need for dialysis or renal transplant, among a large cohort of adults with CKD.Among 206 229 adults with CKD, 16 463 (8.0%) developed incident atrial fibrillation.Incident atrial fibrillation was independently associated with a 67% increased relative rate of end-stage renal disease, even after adjustment for demographics, cardiovascular risk factors, and pertinent medication use.This association was strong and consistent among all age, race, sex, and CKD category subgroups.Therefore, incident atrial fibrillation may be an important risk factor for progression of CKD to end-stage renal disease.Further study is needed to identify potentially modifiable pathways through which atrial fibrillation leads to a higher risk of progression to end-stage renal disease.See p 569.
THE MODERN READING OF TEA LEAVES
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mortality Attributable to HIV Infection/ AIDS—United States, 1981-1990
Journal: JAMA (1991)

From 1981 through 1990, 100,777 deaths among persons with acquired immunodeficiency syndrome (AIDS) were reported to CDC by local, state, and territorial health departments; almost one third (31,196) of these deaths were reported during 1990. During the 1980s, AIDS emerged as a leading cause of death among young adults in the United States. By 1988, human immunodeficiency virus (HIV) infection/AIDS had become the third leading cause of death among men 25-44 years of age and, by 1989, was estimated to be second, surpassing heart disease, cancer, suicide, and homicide (Figure 1). In 1988, HIV infection/AIDS ranked eighth among causes of death among women 25-44 years of age (Figure 2); in 1991, based on current trends, HIV infection/AIDS is likely to rank among the five leading causes of death in this population (1).
A Treatise on Diseases of the Hair.
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Heavy Metal Exposure from Foods
Authors: K. R. Mahaffey, P. E. Corneliussen, C. F. Jelinek, J. A. Fiorino
Journal: Environmental Health Perspectives (1975)

The Food and Drug Administration has a continuing program of monitoring foods for their content of lead, cadmium, mercury, zinc, arsenic, and selenium to determine trends of increasing or decreasing levels. The monitoring protocol is that of the Total Diet Study, in which
Congress and a Health Bureau or National Board of Health.
Journal: JAMA (1885)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A phase II study of gefitinib in combination with FOLFOX-4 (IFOX) in patients with metastatic colorectal cancer
Authors: G. A. Fisher, T. Kuo, C. D. Cho, J. Halsey, C. N. Jambalos, E. J. Schwartz, R. V. Robert, R. H. Advani, H. A. Wakelee
Journal: Journal of Clinical Oncology (2004)

3514 Background: Gefitinib (ZD1839, Iressa) is an inhibitor of epidermal growth factor receptor-1 and has been shown to produce growth inhibition and shrinkage in human tumors. Here we report the preliminary results of a trial to evaluate the efficacy and toxicity of Gefitinib (I) with FOLFOX-4 in patients (pts) with advanced colorectal cancer. Methods: Each cycle consisted of 14 days. Cycle 1 consisted of FOLFOX-4 while cycle 2 and subsequent cycles consisted of FOLFOX-4 with gefitinib at 500 mg PO qd. Pts were stratified by prior therapy for metastatic disease; Group A with no prior therapy and Group B with prior therapy Results: 56 pts have been enrolled (Group A: N=32; Group B: N=24) to date. Median age 54 years (range, 37–79) and median ECOG PS 0 (range 0–1). No patient had prior oxaliplatin. 359 cycles have been administered to date. All pts were assessable for toxicity and 49 were assessable for response. Two pts withdrew prior to completing 4 cycles due to unacceptable toxicity. Grade 3/4 toxicities included neutropenia (53%), diarrhea (49%), nausea (28%), and vomiting (21%). There was one treatment-related death (E. coli sepsis). In Group A, 21 of 27 pts (78%) achieved a partial response (PR). Nine patients in Group A went on to have liver metastases resected; only four of whom were deemed to have resectable disease at study entry. In Group B, 8 of 22 pts (36%) achieved PR. 18 of 22 Group B pts (82%) had received both Irinotecan and 5-FU. Conclusions: Gefitinib with FOLFOX 4 represents an active regimen with response rates that are thus far encouraging compared with previously reported results using FOLFOX alone. Accrual continues to date. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration AstraZeneca; Bristol-Myers Squibb; Genentech; Sanofi-Synthelabo Roche AstraZeneca
Abstract 1128: The Leukocyte Integrin Mac-1 Promotes Acute Cardiac Allograft Rejection
Authors: Koichi Shimizu, Peter Libby, Masashi Sakuma, Yunmei Wang, Richard N Mitchell, Daniel I Simon
Journal: Circulation (2007)

Background: In allograft rejection, donor endothelial cells (EC) are the principal early targets of host leukocytes and alloantibodies. Although the leukocyte integrin Mac-1(αmβ2, CD11b/ CD18) facilitates leukocyte-leukocyte as well as leukocyte-EC interactions, its roles in allograft survival and vasculopathy remains unclear. This study used murine cardiac transplantation to test the hypothesis that Mac-1 deficiency in the recipient reduces accumulation of graft infiltrating cells and attenuates cardiac allograft rejection. Results: In total-allomismatched murine cardiac allografts (BALB/c donor hearts and C57BL/6 recipients), survival averaged 13.8 ± 2.3 days (n=6) for allografts in Mac-1-deficient (Mac-1−/−) recipients compared to 8.3 ± 1.3 days (n = 18, p&lt;0.0001) in wild-type (WT) recipients. At 7 d post-transplantation, allografts in Mac-1−/− recipients had significantly lower parenchymal rejection (PR) scores (2.3 ± 0.4) than WT recipients (3.0 ± 0.4, p&lt;0.01). Allograft accumulation of neutrophils, T cells, and macrophages (Mϕ) significantly diminished in Mac-1−/− compared to WT recipients. To determine the cell type involved in acute graft dysfunction, we performed adoptive transfer experiments. Adoptive transfer of WT, but not Mac-1−/−, Mϕ exacerbated parenchymal rejection of 7-day allografts placed into Mac-1−/− recipients (PR score: 2.3 ± 0.4 for WT vs. 1.5 ± 0.5 for Mac1−/− Mϕ; p &lt; 0.05), and significantly reduced graft survival (8.0 ± 1.4 vs. 13.5 ± 2.6 days, p&lt;0.01). Neither WT nor Mac-1−/− neutrophil adoptive transfer affected graft survival in Mac-1−/− recipients. Mac-1−/− Mϕ co-cultured with allo-EC (BALB/c) expressed significantly lower levels of the co-stimulatory molecules CD40 and CD80, and mixed leukocyte reaction using allo-EC-primed Mac-1−/− Mϕ showed significantly lower antigen-presenting function than WT Mϕ. Despite attenuating acute rejection, recipient Mac-1-deficiency did not prevent graft arterial disease. Conclusion: These studies demonstrate that Mac-1 contributes to acute allograft rejection by modulating macrophage recruitment, antigen presentation, and T cell priming. These observations establish a molecular target for modulating recipient responses to prolong graft survival.
Misunderstanding
Authors: Eric L. Dyer
Journal: Annals of Internal Medicine (1993)

Ad Libitum15 April 1993MisunderstandingEric L. Dyer, MDEric L. Dyer, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-118-8-199304150-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Morning rounds, the intern's order: Discontinue TLC, a word and three letters puzzling to me, displayed so near approaching death and this cold robot of volume and flow quantitating every breath. How inappropriate, it seems, to discontinue tender loving care for this spare woman scored with tearsstrange enough for me, embarrassed to inquire of love with a stethoscope tickling my ears, to ask her nurse the meaning of this doctor's order.Oh, she reported, that's Triple Lumen Catheter in this ICU.So, now I understand the meaning of TLC in room 262, where we are headed this morning, what a ... Author, Article, and Disclosure InformationAffiliations: Previousarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEpilepsy Suspected Seizure and Control in a California Sea Lion(Zalophus californianus) 15 April 1993Volume 118, Issue 8Page: 647KeywordsIntensive care unitsLumen cathetersNurses Issue Published: 15 April 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Peanut, Milk, and Wheat Intake During Pregnancy Is Associated With Reduced Allergy and Asthma In Children
Authors: Supinda Bunyavanich, Sheryl Rifas-Shiman, Thomas A.E. Platts-Mills, Lisa J. Workman, Joanne Sordillo, Carlos Camargo, Matthew Gillman, Diane R. Gold, Augusto A. Litonjua
Journal: Journal of Allergy and Clinical Immunology (2014)
Declining Prevalence of No Known Major Risk Factors for Heart Disease and Stroke Among Adults—United States, 1991-2001
Journal: JAMA (2004)

Despite declines in recent years, heart disease and stroke remain the first and third leading causes of death in the United States, respectively. Of all U.S. deaths in 2001, heart disease accounted for 29.0% and stroke for 6.8%. The major risk factors for both conditions are high blood pressure, high cholesterol, diabetes, smoking, and obesity, all of which have been targeted by national prevention programs. In addition, the prevalence of multiple major risk factors has been a matter of increasing concern. However, few studies of national and state-level data have examined the prevalence of no known major risk factors among adults and how that prevalence has changed during the preceding 10 years. To assess changes in prevalence of no known risk factors for heart disease and stroke during 1991-2001, CDC analyzed data from the Behavioral Risk Factor Surveillance System (BRFSS). This report summarizes the results of that analysis, which indicate that prevalence of no known major risk factors is decreasing among men and women in nearly all states, racial/ethnic populations, age groups, and education levels. In addition, the prevalence of individual major risk factors is increasing. These findings underscore the potential for an increased burden of heart disease and stroke on the health-care system. To prevent the debilitating outcomes of heart disease and stroke among the aging U.S. population, increased prevention efforts and treatment interventions are needed.
THE FEMALE MEMBERSHIP IN THE BRITISH MEDICAL ASSOCIATION.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Scientists ponder diet's behavioral effects
Authors: K. Simmons
Journal: JAMA (1985)

How "what you eat may affect the way you act" was the theme of a conference convened by the American Medical Association, the International Life Sciences Institute, and the Nutrition Foundation. "Diet and Behavior: A Multidisciplinary Evaluation" attracted a group of about 275 scientists, who discussed the effects of diet and nutrients on such behaviors as sleep, cognitive functioning, criminality, and hyperactivity. At the same time that speakers expressed caveats about prematurely manipulating the diet to correct aberrant behavior, they appeared to agree that at least certain foods can indeed influence certain behaviors. And, as their testimony indicates, dietary pharmacology is no longer at the fringe of medicine. According to Robin B. Kanarek, PhD, associate professor of psychology, Tufts University School of Nutrition, Medford, Mass, "ideas and beliefs about a causative role for diet and behavior have existed for literally thousands of years." She notes that therapeutic uses for food
Retrospective Address: Delivered at the Seventh Anniversary of the Reading Pathological Society, June 21st, 1848
Authors: C. Vines
Journal: BMJ (1848)

THE RESPIRATORY SYSTEM.From the nervous we pass on to the diseases of the respiratory system.On the 19th January, 1848, Mr. May presented the larynx and trachea of a boy, aged tour and a half, who died with symptoms of croup.The rima glottidis was extremelv amall; mucous and sub-mucous tissues engorged and vascular; a slight ulceration within the glottis, and the opening blocked up with a small firm muco-purulent mass.The in- flammation did not extend below the larynx; duration of the disease, two days.The treatment consisted of caustics, local bleeding, tartarized antimony, calomel and hot fomentations.Tracheotomy was considered, but not performed, in accordance with the prevailing medical opinion in this country.Mr. May remarked, that though in croup the inflammation generally involved the tracbea and bronchi, more or less, it might be limited to the opening of the glottis, and that thisNo. 22, November 1, 1848.
THE STEREOGNOSTIC SENSE.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CONCERNING SNAPSHOT DIAGNOSIS.
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The University Marine Biological Association.
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hypophysäre Krankheitsbilder
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal