tbuckley/cabot-search huggingface dataset:
Microbial Contamination of Shellfish: Prevalence, Risk to Human Health, and Control Strategies
Authors: R. J. Wittman
Journal: Annual Review of Public Health (1995)

There has been significant concern in recent times about the safety of molluscan shellfish for human consumption. Despite extensive efforts to assure a safe supply of molluscan shellfish, the number of cases of disease and death are still great enough to cause concern among the public. The number of cases of illness and death associated with the ingestion of shellfish falls in the lower end of the range of other similar microbial pathogen-related foodborne disease. Disease and deaths due to viruses and naturally occurring bacteria are now of greatest concern because they are the most often cited casusative agents. The greatest risk of disease or death due to shellfish consumption is among the population with underlying health conditions who choose to consume raw shellfish. Control strategies to limit shellfish-borne disease should focus upon disease and death caused by viruses and naturally occurring bacteria among at-risk populations.
Abstract 3983: An efficient new detection method of colorectal cancers from blood samples
Authors: Joon Kim, Seon Hahn Kim, Kyung-Hwan Cho, Yeongkeun Kwon, Tae-Sung Kim, YouJin Jung, Hag Dong Kim
Journal: Cancer Research (2019)

Abstract Colorectal cancer incidence in Korea is known to be one of the highest in the world. However, the detection methods from patients’ blood samples show relatively inefficient. Ribosomal protein S3 (rpS3), a multifunctional protein with a DNA repair endonuclease activity, has been known to be overexpressed and secreted from cancer cells but not from normal cells. Western blotting using antibodies against rpS3 protein revealed that this protein is overexpressed from cancer tissues of colorectal cancer patients comparing to normal tissues from the same patients. However, other proteins including other ribosomal proteins did not show this phenomenon. We also tested the secretion level of the protein using newly developed S3-1 antibody in the serum samples from 50 colorectal cancer patients and 50 healthy people to test the possibility as a cancer marker. All the diagnosed blood samples which were randomly selected among subjects in National Biobank of Korea were collected and serum was acquired by centrifugation. Samples were analyzed by dot blotting and ELISA methods. The detection level of S3-1 from the serum of colorectal cancer patients showed significantly higher than that from healthy control group. Also more than 60% from colorectal cancer patients’ serum showed sensitivity signals with 90% specificity which are significantly better than those of CEA or CA19-9 showing a possibility as a novel colorectal cancer biomarker. Citation Format: Joon Kim, Seon Hahn Kim, Kyung-Hwan Cho, Yeongkeun Kwon, Tae-Sung Kim, YouJin Jung, Hag Dong Kim. An efficient new detection method of colorectal cancers from blood samples [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3983.
CONSTITUTION AND HEART DISEASE
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 2440: The microRNA-mRNA interactions in <i>ALK</i>-rearranged lung adenocarcinoma
Authors: Sophia Subat, Kentaro Inamura, Hironori Ninomiya, Hiroko Nagano, Sakae Okumura, Yuichi Ishikawa
Journal: Cancer Research (2019)

Abstract Background: ALK-rearranged lung adenocarcinoma, which is responsive to ALK inhibitors, exhibits distinct clinicopathological and molecular features. In ALK-rearranged lung cancer, miRNA/mRNA expression signatures or individual miRNA-mRNA interactions have been reported. However, no study has performed integrative analysis to identify comprehensive miRNA-mRNA interactive network in this type of tumor. Therefore, we conducted this study to reveal a landscape of miRNA-mRNA interactions present in ALK-rearranged lung adenocarcinoma. Methods: To identify differentially expressed miRNAs and mRNAs according to ALK-rearranged status, microarray expression profiling was conducted using 77 surgically resected specimens of lung adenocarcinoma with a known ALK status (42 ALK-positive and 35 ALK-negative cases). We made a multistep bioinformatics approach to build an miRNA-mRNA regulatory network observed in ALK-rearranged lung tumors. Results: Seventy-three miRNAs (comprising 56 downregulated and 17 upregulated miRNAs) were differentially expressed according to ALK-rearranged status. The 56 miRNAs included miR-19a-3p, miR-362-5p, and miR-340-5p, all of which have been reported to be downregulated in ALK-rearranged lung tumors. On the basis of miRNA expression data, we identified 80 distinct biological processes in ALK-positive tumors, which included “proteoglycans in cancer”, “FoxO signaling pathway”, “pathways in cancer”, “mTOR signaling pathway”, and “HIF-1 signaling pathway”. The mRNA expression signature of ALK-rearranged tumors included ALK, ETV1, and CX3CL1, all of which have been associated with lung tumorigenesis or tumor progression. Integrative analyses of miRNA and mRNA expression data revealed a refined list of putative miRNA-mRNA correlations. Of 136 putative miRNA-mRNA interactions, we identified 101 distinctive interactions with potential involvement in oncogenic machinery in ALK-positive tumors, such as miR-19a-3p/TLR2, miR-362-5p/SLC34A2, miR-1260b/ETV1, and miR-4481/CX3CL1 pairs. Network structural analysis provided a comprehensive view of complex miRNA-mRNA interactions in ALK-rearranged lung adenocarcinoma. Conclusion: Overall, this observational study provides insight into the unique miRNA-mRNA regulatory network present in ALK-rearranged lung adenocarcinoma. Our findings, if validated, would inform future research examining the interplay of miRNAs and mRNAs in ALK-rearranged tumors. Citation Format: Sophia Subat, Kentaro Inamura, Hironori Ninomiya, Hiroko Nagano, Sakae Okumura, Yuichi Ishikawa. The microRNA-mRNA interactions in ALK-rearranged lung adenocarcinoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2440.
Night Thoughts
Authors: George N. Braman
Journal: Annals of Internal Medicine (2007)

Ad Libitum15 May 2007Night ThoughtsGeorge N. Braman, MDGeorge N. Braman, MDFrom Bronx, NY 10471.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-146-10-200705150-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail “Thus conscience does make cowards of us all …”—William Shakespeare, Hamlet, Act III, Scene I... Author, Article, and Disclosure InformationAffiliations: From Bronx, NY 10471.Current Author Address: George N. Braman, MD, 6142 Delafield Avenue, Bronx, NY 10471. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 May 2007Volume 146, Issue 10Page: 756KeywordsFallsSleepSurgeons ePublished: 15 May 2007 Issue Published: 15 May 2007 Copyright & PermissionsCopyright © 2007 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Green's Encyclopedia and Dictionary of Medicine and Surgery.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PHRENIC HERNIA
Authors: E. Copeman
Journal: BMJ (1855)

THEc remarks I am about to make refer to a case of unusual occurrence, a disease about which, as far as I how, there is not much information to be obtained from published records.Such reports as I have been able to find, after a not very prolonged search, I shall bring before you in a condensed form, after having noticed the particular case which leads to these observations.The brief history is, that I was summoned to a patient, -aged 38 years, whom I found in a dying state, with great dyspnwa, cold extremities, and an almost imperceptible pulse.She was a fat woman, of middle height, the mother of several children, and again pregnant.She had for seve- mal years been the subject of umbilical hernia, about the size of a large orange, and caused by exertion during one of her labours.Four days before I saw her, she had been attacked with pain in the left shoulder and arm, extending to, and fixing itself in the region of the stomach.Vomiting soon followed, and became more and more frequent, until every- thing she took was almost immediately returned.There was no alvine evacuation, but the matter vomited was not stercoraceous.Next came fixed pain in the left side of the chest, and hurried breathing, terminating in death.On examining the body, it was found that the peritoneum was perfectly healthy, and there was no constriction in the situation of the umbilical hernia.A considerable portion of the stomach had passed upwards through an opening in the diaphragm large enough to admit three fingers, about two inches anterior and to the left of the natural cesophagean opening.Probably more than a third of the stomach, together with a portion of omentum, both very much in- famed, had escaped through this opening, and excited severe inflammation of the pleura, in the cavity of which they lay.The left side of the chest contained a considerable quantity of serum and recently formed lymph; and
Hydatid disease.
Authors: U G Meneghelli, A L Martinelli, M G Villanova
Journal: Gut (1995)

Intestinal permeability EDITOR,-We read with interest the paper by Dr Oriishi and colleagues (Gut 1995; 36: 891-6) investigating intestinal permeability and the immune response to enteric bacterial antigens in patients with inflammatory bowel disease.Their finding of an increased systemic concentration of antibodies to lipid A in patients with inflammatory bowel disease is in agreement with studies showing increased titres of antibodies to the endotoxin core,l to peptidoglycan-polysaccharide complexes,2 and to a variety of enteric bacteria3 in these diseases.These studies offer indirect evidence of mucosal barrier dysfunction in patients with inflammatory bowel disease, which supports the more direct evidence provided by the measurement of systemic endotoxin concen- tration or by bacterial culture studies.' 4
THE QUARTERLY JOURNAL OF MEDICINE.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Possible cyclosporin–danazol interaction in a patient with aplastic anaemia
Authors: J. Borrás‐Blasco, J.D. Rosique‐Robles, J. Peris‐Marti, J. Navarro‐Ruiz, M. Gonzalez‐Delgado, V. Conesa‐Garcia
Journal: American Journal of Hematology (1999)
BOOK REVIEWS
Authors: P. M. WILCOX
Journal: JNCI Journal of the National Cancer Institute (1990)

BOOK REVIEWS Get access Dr. Susan Love's Breast Book . Susan M. Love with Karen Lindsey . Reading, Mass : Addison-Wesley Publishing Co. , 1990 , 455 pp. $18.95. PATTI M. WILCOX PATTI M. WILCOX Consultation Unit, The Johns Hopkins Oncology Center550 N Broadway, Suite 1003 Dr. Baltimore, MD 21205 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 82, Issue 21, 7 November 1990, Page 1717, https://doi.org/10.1093/jnci/82.21.1717 Published: 07 November 1990
Endoscopic ultrasonography
Authors: M. Bhutani
Journal: Endoscopy (2007)

A large number of abstracts on the subject of endoscopic ultrasound (EUS) were presented at Digestive Disease Week 2007, and it would be a difficult task to review each and every abstract in this article. However, in making a selection I have highlighted a number of abstracts that have explored new, emerging, or controversial issues. I have also selected other abstracts based on these, following a common theme, because it is not uncommon for interesting and brilliant ideas to occur at the same time to independent and unconnected groups of scientists and researchers.
What's new this month in BMJ Journals
Authors: Harvey Marcovitch
Journal: BMJ (2006)

Silence soothes the savage breastDifferent types of music (and silence) have a detectable effect on blood flow, blood pressure, and breathing characteristics.Twelve musicians and 12 controls listened in random order to six types of music: slow and fast classical, dodecaphonic, techno, rap, and raga.They were monitored throughout for heart rate, blood pressure, cerebral artery blood velocity, respiratory movements, and end tidal CO 2 .In all subjects, breathing rate, heart rate and blood pressure increased proportionally to the tempo and, perhaps, complexity of the rhythm.Music style or personal preference had little effect.Musicians had slower baseline breathing rates but breathed faster than controls at faster tempos, presumably because they are trained to breathe in synchrony with music.Pauses for silence reduced all the variables so that the subjects were more relaxed than when music was playing.The authors speculate that pleasure may arise from controlled alternation between arousal and relaxation.They suggest this phenomenon could be used to reduce sympathetic activity and induce relaxation in cardiac patients.
A Genetic Disorder Reveals a Hematopoietic Stem Cell Regulatory Network Co-Opted in Leukemia
Authors: Richard Voit, Liming Tao, Fulong Yu, Blake Cohen, Liam Cato, Xiaotian Liao, Claudia Fiorini, Satish Kumar Nandakumar, Lara Wahlster, Kristian Teichert, Aviv Regev, Vijay G. Sankaran
Journal: Blood (2021)
Acute gastric anisakiasis. Analysis of 178 cases
Authors: K. Sugimachi
Journal: JAMA (1985)

From 1969 to 1984, we treated 178 patients with acute gastric anisakiasis caused by gastric mucosal penetration of the<i>Anisakis</i>larvae. Because the larvae of<i>Anisakis</i>can always be observed by endoscopy and removed with biopsy forceps, early performance of endoscopy is highly recommended for patients in whom acute gastric anisakiasis is suspected and for those who have eaten raw fish within 12 hours before onset of the gastric symptoms. Endoscopic removal is essential to relieve the intolerable pain; after relief, the administration of antacids will repair the damaged gastric mucosa. Ulcer formation is rare. (<i>JAMA</i>1985;253:1012-1013)
The Fate of Trenbolone Acetate and Melengestrol Acetate after Application as Growth Promoters in Cattle: Environmental Studies
Authors: Bettina Schiffer, Andreas Daxenberger, Karsten Meyer, Heinrich H. D. Meyer
Journal: Environmental Health Perspectives (2001)

The steroids trenbolone acetate (TbA) and melengestrol acetate (MGA) are licensed as growth promoters for farm animals in several meat-exporting countries. Although many studies have explored their safety for both animals and consumers, little is known about their fate after excretion by the animal. Our study aimed to determine the residues and degradation of trenbolone and MGA in solid dung, liquid manure, and soil. In animal experiments lasting 8 weeks, cattle were treated with TbA and MGA. Solid dung and, in case of trenbolone, liquid manure were collected and spread on maize fields after 4.5 and 5.5 months of storage, respectively. Determination of the hormone residues in all samples included extraction, clean-up (solid-phase extraction), separation of metabolites and interfering substances by HPLC (RP-18), and quantification by sensitive enzyme immunoassay. Procedures were validated by mass spectrometry (MS) methods. During storage of liquid manure the level of trenbolone decreased from 1,700 to 1,100 pg/g (17alpha-isomer), corresponding to a half-life of 267 days. Before storage, the concentrations in the dung hill ranged from 5 to 75 ng/g TbOH and from 0.3 to 8 ng/g MGA. After storage, levels up to 10 ng/g trenbolone, and 6 ng/g MGA were detected. In the soil samples trenbolone was traceable up to 8 weeks after fertilization, and MGA was detected even until the end of the cultivation period. The results show that these substances should be investigated further concerning their potential endocrine-disrupting activity in agricultural ecosystems.
INTRADERMAL VACCINATION
Authors: John N. Force
Journal: JAMA (1925)

<h3>To the Editor:</h3> —In a reply to an inquiry regarding intradermal vaccination (The Journal, January 17, p. 223) occurs the sentence, "To class the Force method with the intradermal method is likely to be confusing, for his description of the method used appears to be subcutaneous rather than intracutaneous." I have never published a description of the method used at this university, and I am at a loss to determine on what this opinion is based. Recently I sent a personal communication to Dr. J. C. Geiger of the University of Chicago, giving directions for intradermal vaccination, in which these words occur: "The needle should not enter the subcutaneous tissue, and the bevel should not show through the epidermis. The proper site for an intradermal smallpox vaccination is neither subcutaneous (as in the ordinary hypodermic injection), nor subepidermal (as in the Schick test), but<i>intradermal</i>." I might further amplify this
Review and Update of Leukemia Risk Potentially Associated with Occupational Exposure to Benzene
Authors: Susan M. Brett, Joseph V. Rodricks, Vernon M. Chinchilli
Journal: Environmental Health Perspectives (1989)

Since the 1980 U.S. Supreme Court decision on the Occupational Safety and Health Administration's (OSHA) proposal to lower the occupational benzene standard from 10 ppm to 1 ppm, numerous quantitative assessments of the leukemia risk of benzene exposure have been prepared. The primary difference between these risk assessments has been in the way in which benzene exposure has been estimated and in the models applied to describe the dose-response relationship. The more recent assessments, in attempting to estimate benzene exposures on an individual basis, and in applying models which make maximal use of the available data points, represent a substantial improvement over earlier assessments. In this paper, we will review the available risk assessments and the data upon which they are based and will present our own assessment, which builds on prior efforts. Our reevaluation of the underlying data on the cohort that we judged to be most suitable for quantitative risk analysis suggested that past assessments may have overestimated risk by a factor of 3 to 24. In addition, we will present some recently made available data of relevance to the benzene exposure histories of cohort of concern. These data provide additional suggestion that the total benzene exposure of certain members of this cohort has likely been seriously underestimated, the extent to which remains to be determined. Further analysis of these data and pursuit of additional sources to improve the characterization of the benzene exposure of this cohort appear to be warranted in order to define more precisely the benzene-leukemia dose-response relationship.
Identification of cell cycle–arrested quiescent osteoclast precursors in vivo
Authors: Toshihide Mizoguchi, Akinori Muto, Nobuyuki Udagawa, Atsushi Arai, Teruhito Yamashita, Akihiro Hosoya, Tadashi Ninomiya, Hiroaki Nakamura, Yohei Yamamoto, Saya Kinugawa, Midori Nakamura, Yuko Nakamichi, Yasuhiro Kobayashi, Sakae Nagasawa, Kimimitsu Oda, Hirofumi Tanaka, Mitsuo Tagaya, Josef M. Penninger, Michio Ito, Naoyuki Takahashi
Journal: The Journal of Experimental Medicine (2009)
THE FUEL FOR STRENUOUS EXERCISE
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal