tbuckley/cabot-search huggingface dataset:
Buying Patients.
Authors: T. D. Crothers
Journal: JAMA (1898)

Hartford, Conn., Dec. 1, 1898. <h3>To the Editor:</h3> —Recently a physician who has attained some prominence in his neighborhood, wrote me asking what I was accustomed to give the family physician who sent his patient to my care. I replied that I never bought practice and never gave anything to physicians who sent me cases. He answered that he always received a fee of $10 for sending cases who could pay $20 and more a week. Where the bills amounted to several hundred dollars, most medical men sent him 5 per cent. on all accounts over $200. From inquiries I found that two gold cure establishments had received some cases from this physician and an obscure New York specialist had also received and treated some cases sent by him. Within five years, since the prominence of "gold cures," I have heard of offers of this kind from managers of such
Randomized, controlled trial of clonidine for smoking cessation in a primary care setting
Authors: P. Franks
Journal: JAMA (1989)

Clonidine hydrochloride has been reported to reduce tobacco withdrawal symptoms and facilitate smoking cessation. We enrolled 185 subjects, 92 receiving clonidine and 93 receiving placebo, in a randomized, double-blind study of clonidine for smoking cessation in a primary care setting. Clonidine had no demonstrable effect on withdrawal (8 of 11 measures favoring placebo). At 4 weeks, 17 (18%) subjects receiving clonidine had quit compared with 13 (14%) receiving placebo (χ<sup>2</sup>= 0.7; 90% confidence interval of benefit from clonidine, —4% to 13%). At 4 weeks, the mean number of cigarettes smoked was 17.7 for those receiving clonidine and 17.5 for those receiving placebo (<i>t</i>=0.1; 90% confidence interval of benefit from clonidine, —4.1 to 3.7 cigarettes per day). These results provide little support for a beneficial effect of clonidine on tobacco withdrawal symptoms, quitting, or smoking reduction in a primary care setting. (<i>JAMA</i>. 1989;262:3011-3013)
Surgery Gynecology and Obstetrics, Chicago
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reply
Authors: Don C. Rockey, Stephen H. Caldwell, Zachary D. Goodman, Rendon C. Nelson, Alastair D. Smith
Journal: Hepatology (2009)

We thank Dr. Puoti and colleagues for their interest in our article, and appreciate the identification of an important issue in everyday clinical practice. Not only do the authors make a valid point about the potential disparity between a "normal" alanine aminotransferase (ALT) concentration and the presence of clinically important hepatic fibrosis, they also raise two further issues. First, there is continuing debate as to what constitutes a "normal ALT" level.1-3 There is evidence to suggest that a value above 19 IU/L in a woman and 25 IU/L in a man should be considered abnormal, whereas the upper limit of the normal range at many clinical laboratories (be this in community or academic medical center settings) is 40 U/L, and in some instances higher still. Second, we believe that the authors may have understated the importance of the role of liver biopsy in management of patients with a normal ALT concentration and chronic hepatitis C virus (HCV) infection: it is the information that liver histology provides in the context of the clinical picture that is critical. These data may mean the difference between embarking upon antiviral therapy or not. For example, a patient with minimal fibrosis but an otherwise unfavorable treatment outcome profile (obese, African American, male, genotype 1) could very well be counseled to wait for additional therapies, particularly if his duration of infection is longstanding. Alternatively, the clinician might be more aggressive with a young patient having fibrosis that borders on advanced, and who has a favorable treatment outcome profile. Thus, biopsy and histological assessment can play an important role in decision-making in the setting of HCV with normal aminotransferases. To the extent that human immunodeficiency virus (HIV) modifies the fibrogenic response to HCV, as intimated by Puoti et al., we believe histologic assessment is often even more important in this setting. Therefore, we endorse the view that liver biopsy is potentially very useful in patients with HCV, with or without HIV. Don C. Rockey M.D.*, Stephen H. Caldwell M.D. , Zachary D. Goodman M.D. , Rendon C. Nelson M.D.§, Alastair D. Smith MB, ChB, FRCP (Glasg)¶, * Division of Digestive and Liver Diseases, University of Texas Southwestern Medical Center, Dallas, TX, Gastroenterology Division, University of Virginia, Charlottesville, VA, Armed Forces Institute of Pathology, Washington, DC, § Department of Radiology, Duke University Medical Center, Durham, NC, ¶ Department of Gastroenterology Division Department of Medicine, Duke University Medical Center, Durham, NC.
Biotechnology industry calls for active US role
Authors: C. Marwick
Journal: JAMA (1994)

SIGNS that the biotechnology industry is not growing as fast in the mid 1990s as it did in the 1980s have the industry's members, academic leaders, and investors worried. They have joined in an effort to halt any further erosion and to shape a national agenda to ensure United States preeminence in biotechnology. If the meeting they held in Washington, DC, described as the National Biotechnology Summit, did not exactly allay the industry's fears for the future, it did examine some of the problems the industry faces. Speaker after speaker pointed with alarm to cuts in federal funding for medical research, delays in drug approval, and doubts about the way new drug price controls, likely to be incorporated into health system reform legislation, may work. <h3>Expensive Toys?</h3> More than one speaker called up the specter of an administration that they say views new medical technologies as expensive toys to be
Effect of training traditional birth attendants on neonatal mortality (Lufwanyama Neonatal Survival Project): randomised controlled study
Journal: BMJ (2011)

Effect of training traditional birth attendants on neonatal mortality (Lufwanyama Neonatal Survival Project): randomised controlled studyAn incorrect numerator was used to calculate the rate ratio of neonatal deaths from serious infection in this paper by Christopher J Gill and colleagues (
Overexpression of E2F1 in glioma-derived cell lines induces a p53-independent apoptosis that is further enhanced by ionizing radiation
Authors: Hui-Kuo G. Shu, Carol M. Julin, Felix Furman, Garret L. Yount, Daphne Haas-Kogan, Mark A. Israel
Journal: Neuro-Oncology (2000)

Glioma cell lines show variable responses to radiation in a manner in uenced by their p53 status.Irradiation of glioma cell lines does not generally induce apoptosis.When wild-type p53 is present, these cells undergo a G 1 arrest that is closely associated with increased radiosensitivity as measured by clonogenic survival.Previously, others have shown that dysregulated overexpression of E2F1 induces apoptosis in cell lines with either functional or inactivated p53.We found that regardless of p53 status, apoptosis induced by overexpression of E2F1 in glioma cell lines was further enhanced by treatment with ionizing radiation.BAX induction did not follow E2F1 overexpression or irradiation in the glioma cell lines tested.Thus, the apoptotic response of glioma-derived cells to irradiation can be enhanced by E2F1 by a mechanism that does not involve the induction of BAX.
THE BENEFICENT SPIDER.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CAPE TOWN
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Presse Médicale, Paris
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Chart to Illustrate the History of Biochemistry and Physiology.
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Arthropathy as the major clinical indicator of occult iron storage disease
Authors: A. M'Seffar
Journal: JAMA (1977)

Chronic arthritis was the only symptom that led to the detection of increased iron stores in four patients. In these persons, the serum iron was ordered at the time of initial examination, and ranged from 212 to 237 μg/dl with a transferrin saturation of 83% to 100%. Liver biopsy specimens showed hepatocyte iron deposition in each person, with definite cirrhosis in only one patient. These cases illustrate that a chronic arthropathy may be the first clinical manifestation of iron overload, and can lead to discovery of the disease in patients and their family members. Treatment may then be initiated before extensive tissue damage has occurred. (<i>JAMA</i>238:1825-1828, 1977)
Medical Education and the Regulation of the Practice of Medicine in the United States and Canada.
Journal: JAMA (1884)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CLAUDE BERNARD — A RETROSPECT
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reply
Authors: Hideko Kamino, Hiromaru Kiryu, Howard Ratech
Journal: Journal of the American Academy of Dermatology (1991)

as the first melanoma had been euploid; the authors stated that this provided evidence that the second melanoma was an additional primary tumor and not a metastasis.Flow cytometry has been used to demonstrate that the proportion of melanomas that are aneuploid increases in this order: thin primary, thick primary, metastasis.l5This suggests that there is a progressive accumulation of genetic abnormalities as an individual melanoma progresses, a concept that has been supported by cytogenetic 6, 7 and restrietion fragment length polymorphism analyses.8 For this reason, the DNA complement of a metastasis may not be identical to the complement of its primary and, in fact, is likely to be more abnormal.This divergence has been demonstrated in individual patients by cytogenetics and flow cytometry.3, 6,a Thus that the second melanoma in the case of Kamino et al. was aneuploid constitutes, if anything, evidence that it was a metastasis, regardless of the ploidy of the first melanoma.The histologic features of the second melanoma arc indeed consistent with primary melanoma, but the results of flow cytometry do not lend additional support to this diagnosis.
Regulation of monocyte procoagulant activity in acute myocardial infarction: Role of tissue factor and tissue factor pathway inhibitor Ilka Ott, Martin Andrassy, Dominik Zieglg�nsberger, Stefanie Geith, Valerie Malcouvier, Franz-Josef Neumann. 1. Medizinische Klinik und Deutsches Herzzentrum der TU M�nchen, Munich, Germany
Journal: Journal of the American College of Cardiology (2001)
Urokinase
Authors: SOL SHERRY
Journal: Annals of Internal Medicine (1968)

Although a practical and effective form of thrombolytic therapy has not yet been established, progress continues in achieving this objective. Current interest centers about urokinase, a promising thrombolytic agent obtained from human urine. Since a major clinical trial to evaluate urokinase in the treatment of acute pulmonary embolism is scheduled to begin shortly, this article describes the agent's development. The latter, requiring the close cooperation of the scientific community, the pharmaceutical industry, and the National Heart Institute, has resulted in [1] production of preparations suitable for clinical investigation; [2] evidence that the intravenous administration of the agent produces a reasonably predictable, reproducible, and sustained thrombolytic state in man; [3] demonstration that urokinase-induced states of accelerated thrombolytic activity are capable of inciting the lysis of thrombi; and [4] accomplishment of thrombolysis with minimal toxicity except that, on occasion, the thearpy is complicated by excessive bleeding induced by the intense thrombolytic state.
Metaphysical symbolism in 16th- and 17th-century medicine
Authors: P. Krivatsy
Journal: JAMA (1970)

The connections of man and nature have engaged the attention of physicians and philosophers from earliest times. One of the seminal ideas in the history of thought is the relationship expressed by the terms "macrocosm" and "microcosm," the great universe and the individual small universe which mirrors the great one. A world soul was considered to animate the universe, and the human body, with its own soul, was a miniature universe. The events which take place in the great universe found a reflection in the individual man. The ancient Greeks thought much about the problem. Ionian philosophers speculated about the multiplicity of things in nature, and the Pythagoreans and others concluded that a kinship between man and nature must be close, since the universe was one, divine, and eternal. The parallel between man and the cosmos was mentioned by Anaximenes and Democritus. The idea of the macrocosm and the microcosm
AIDS
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Studies of atomic bomb survivors. Understanding radiation effects
Authors: J. D. Boice
Journal: JAMA (1990)

Public concern about ionizing radiation, particularly radiation produced by nuclear processes, originated at the end of World War II, when atomic bombs were dropped on Hiroshima and Nagasaki, Japan. We owe much to the members of the Joint Commission for the Investigation of the Effects of the Atomic Bombs, who, in 1946, had the vision, in the face of the destruction and turmoil brought about by the bombings, to see that essential knowledge on the health effects of radiation might be gained from that dreadful experience.<sup>1</sup> To this end, the epidemiologic studies of atomic bomb survivors have provided the single most important source of information on the immediate and delayed effects of acute, wholebody exposure to ionizing radiation. These ongoing studies are reviewed in three articles in this issue ofThe Journalby Yoshimoto,<sup>2</sup>Yamazaki and Schull,<sup>3</sup>and Shimizu and colleagues.<sup>4</sup>The studies, which are now