tbuckley/cabot-search huggingface dataset:
Cardiac Toxicities of Antibiotics
Authors: H. Richard Adams, Janet L. Parker, Lenard R. Durrett
Journal: Environmental Health Perspectives (1978)

Isolated heart muscle preparations are useful in the study of cardiac toxicities of drugs and environmental chemicals: such tissues allow assessment of chemical effects on heart muscle that is free from indirect in vivo influences that can mask or even accentuate cardiac responses measured in the intact animal. In the present study, left atria of guinea pigs were used to demonstrate a direct cardiac depressant effect of greater-than-therapeutic concentrations of several aminoglycoside antibiotics. The toxic effect of these antibiotics seems to be a calcium-dependent event, and may prove useful to characterize contractile responses of the heart. Other antibiotic agents can also depress cardiovascular function, as summarized in this report, but mechanisms of action have not been clearly defined.
Nocturnal Home Oximetry in Detecting the Sleep Apnea-Hypopnea Syndrome and in Working Up Hypersomnolence
Authors: Alejandro D. Chediak
Journal: Annals of Internal Medicine (1994)

Letters1 March 1994Nocturnal Home Oximetry in Detecting the Sleep Apnea-Hypopnea Syndrome and in Working Up HypersomnolenceAlejandro D. Chediak, MDAlejandro D. Chediak, MDMount Sinai Medical Center; Miami Beach, FL 33140Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-120-5-199403010-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Both the article by Series and colleagues [1] and the editorial by Pack [2] failed to address an important issue when evaluating sleepy patients who have been presumptively diagnosed as having obstructive sleep apnea. Excessive daytime sleepiness does not equate to a diagnosis of obstructive sleep apnea. Many other nonapneic respiratory and nonrespiratory sleep disorders require a comprehensive polysomnogram for diagnosis [3]. Specifically, high resistance during breathing—without apneas, hypopneas, or desaturations—can lead to frequent arousals from sleep and reversible daytime sleepiness [4]. Periodic limb movements of sleep would also be missed if oximetry alone were used.Hypersomnolent ...References1. Series F, Marc I, Cormier Y, La Forge J. Utility of nocturnal home oximetry for case finding in patients with suspected sleep apnea hypopnea syndrome. Ann Intern Med. 1993; 119:449-53. Google Scholar2. Pack A. Simplifying the diagnosis of obstructive sleep apnea. Ann Intern Med. 1993; 119:528-9. Google Scholar3. Diagnostic Classification Steering Committee. International Classification of Sleep Disorders: Diagnostic and Coding Manual. Rochester, Minnesota: ASDA; 1990. Google Scholar4. Guilleminault C, Stoohs R, Clerk A, Cetel M, Maistros P. A cause of excessive daytime sleepiness: the upper airway resistance syndrome. Chest. 1993; 104:781-7. Google Scholar5. A report of the National Commission on Sleep Disorders Research. Wake Up America: A National Sleep Alert. Volume 1; 1993. Google Scholar Author, Article, and Disclosure InformationAffiliations: Mount Sinai Medical Center; Miami Beach, FL 33140 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byUse of Ambulatory Overnight Oximetry to Investigate Sleep Apnea in a General Internal Medicine PracticeSLEEP LABORATORY TESTINGAlternativas a la polisomnografía convencional en el diagnóstico y tratamiento del síndrome de apneas durante el sueño 1 March 1994Volume 120, Issue 5Page: 439-440KeywordsApneaSleepSleep apneaSleep disorders ePublished: 15 August 2000 Issue Published: 1 March 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
In the spotlight: neuroengineering
Authors: N. Thakor
Journal: IEEE Reviews in Biomedical Engineering (2009)

This article reviews some of the highlights of what has been covered and explored at various conferences and published in major journals about neuroengineering. The "hot" areas, at least as measured by popularity and visibility, continue to be the fields of brain-computer interface (BCI) or brain-machine interface (BMI), the application of BMI to neural prosthesis, deep brain stimulation (DBS), neural interface technologies, and brain imaging.
Tracheobronchial cytologic changes during the menstrual cycle
Authors: J. Chalon
Journal: JAMA (1971)

Smears were made from bronchial washings of patients undergoing general endotracheal anesthesia. Cyclic cytomorphologic changes were observed in the ciliated columnar epithelia of younger females but not in epithelia of males and older women. During the proliferative phase of the menstrual cycle, the nuclei of the ciliated cells were found mainly in the basal position. Following ovulation they ascended to mid-position, and as the secretory phase progressed they migrated towards the apex. After approximately the 25th day, increasing numbers of cells with basal nuclei were again noticed. Intracytoplasmic mucopolysaccharide content increased with the ascent of the nucleus. When cells with basal nuclei predominated once more, goblet cells proliferated concurrently, probably indicating metaplasia from ciliated cells with high mucopolysaccharide content. These cyclic fluctuations may possibly protect females from inhaled irritants and carcinogens.
Statins use corrects the impact of direct acting antiviral agents on lipid profile in hepatitis C virus patients
Authors: Andrea Dalbeni, Anna Mantovani, Diego Faccincani, Michele Bevilacqua, Filippo Cattazzo, Donatella Ieluzzi, Veronica Paon, Laura Iogna Prat, David Sacerdoti
Journal: Journal of Hepatology (2020)
Deaths
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MEDICAL BOTANY.
Authors: WILLIAM TRELEASE
Journal: JAMA (1897)

acid and the subsequent use of a 20 per cent, guaiacol spray as recommended by Dr. P. Watson Williams.3In tuberculosis of the air-passages, external applications of pure guaiacol have been recommended by Prof. J. Solis-Cohen, and for this purpose the valer- ianate would have an especial advantage.Internally guaiacol valerianate is given either in milk, in dilute alcohol, or better, in the form of capsules.It checks bronchorrhea and reduces the number of tubercle bacilli in the sputum, at the same time that it tends, to prevent re-infection from the intestinal tract.It is well borne in moderate doses, 10 to 30 minims daily, or one to three capsules, each containing 2 grains, or 3 ;j minims, three times a day.In the treatment of gastric catarrh, chronic gastritis with gastrectasia, and other conditions associated
Journal of Bone and Joint Surgery, Boston
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Addendum: Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge
Authors: Scott G Hansen, Cassandra Vieville, Nathan Whizin, Lia Coyne-Johnson, Don C Siess, Derek D Drummond, Alfred W Legasse, Michael K Axthelm, Kelli Oswald, Charles M Trubey, Michael Piatak, Jeffrey D Lifson, Jay A Nelson, Michael A Jarvis, Louis J Picker
Journal: Nature Medicine (2011)
Abstract 2609: A novel MYB-AR cross-talk promoting castration-resistance in prostate cancer
Authors: Sanjeev Kumar Srivastava, Haseeb Zubair, Girijesh K. Patel, Mohammad Aslam Khan, Sachin Kumar Deshmukh, Seema Sing, Joel Andrews, Bin Wang, James E. Carter, Ajay Pratap Singh
Journal: Cancer Research (2019)

Abstract Progression of prostate cancer from castration-sensitive to castration-resistant disease is a complex process, which likely involves multiple genetic and epigenetic alterations. Here we report a novel mechanism where MYB acts as a novel binding partner of AR enabling its ligand-independent activation to support castration resistance in prostate cancer. MYB and AR interact and co-localize with each other predominantly in the nuclei. Androgen-depletion or enzalutamide treatment does not interfere with MYB-AR interaction, and MYB-overexpressing prostate cancer cells retain AR in the nucleus even when cultured under androgen-deprived condition. Transcriptional activity of KLK3 (an androgen-responsive gene encoding PSA) promoter is increased in MYB-overexpressing cells, while sustained under androgen-depleted condition. In silico analysis identifies a MYB-binding region in KLK3 promoter in close proximity to the AR binding site, and MYB is shown to cooperatively promote AR binding to the KLK3 promoter. MYB-overexpressing prostate cancer cells exhibit greater tumorigenicity when implanted orthotopically and quickly regain growth following castration leading to the poorer survival of mice, compared to those carrying low MYB-expressing prostate tumors. Together, these findings establish a novel and significant role of MYB-AR cross-talk in prostate cancer, which could be exploited for its therapeutic management. Citation Format: Sanjeev Kumar Srivastava, Haseeb Zubair, Girijesh K. Patel, Mohammad Aslam Khan, Sachin Kumar Deshmukh, Seema Sing, Joel Andrews, Bin Wang, James E. Carter, Ajay Pratap Singh. A novel MYB-AR cross-talk promoting castration-resistance in prostate cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2609.
THE ETIOLOGY OF SCURVY.
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
"Proven."
Authors: William H. Dudley
Journal: JAMA (1907)

Los Angeles, Cal., May 23, 1907. <h3>To the Editor:</h3> —Although the rank and file of physicians are educated men, it is nevertheless somewhat surprising how many of them who write and speak publicly, tumble headlong into the habit of using the incorrect expressions and spelling employed by others, without considering accuracy. This is especially true when the example is set by an author who is supposed to be authority on English as well as on medicine. An instance of this is seen in the use of the word proven, the past participle of the word prove. In the discussions in medical meetings and in medical books, the word occurs with surprising frequency. This was noticed recently in a medical work written by twenty-two authors, only one of whom used the expression correctly. I say correctly, taking the Standard Dictionary as authority, which under this word proven, reads: "An improper form
Corticosteroids for Patients With Septic Shock
Authors: Jan G. Zijlstra, Iwan C. C. van der Horst, Jaap E. Tulleken, Tjip S. van der Werf, Jack J. M. Ligtenberg
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Journal of Gerontology, St. Louis
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Evaluation of a New Minor Tranquilizer
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Systems-level analysis of age-related macular degeneration reveals global biomarkers and phenotype-specific functional networks
Authors: Aaron M Newman, Natasha B Gallo, Lisa S Hancox, Norma J Miller, Carolyn M Radeke, Michelle A Maloney, James B Cooper, Gregory S Hageman, Don H Anderson, Lincoln V Johnson, Monte J Radeke
Journal: Genome Medicine (2012)

Age-related macular degeneration (AMD) is a leading cause of blindness that affects the central region of the retinal pigmented epithelium (RPE), choroid, and neural retina. Initially characterized by an accumulation of sub-RPE deposits, AMD leads to progressive retinal degeneration, and in advanced cases, irreversible vision loss. Although genetic analysis, animal models, and cell culture systems have yielded important insights into AMD, the molecular pathways underlying AMD's onset and progression remain poorly delineated. We sought to better understand the molecular underpinnings of this devastating disease by performing the first comparative transcriptome analysis of AMD and normal human donor eyes. RPE-choroid and retina tissue samples were obtained from a common cohort of 31 normal, 26 AMD, and 11 potential pre-AMD human donor eyes. Transcriptome profiles were generated for macular and extramacular regions, and statistical and bioinformatic methods were employed to identify disease-associated gene signatures and functionally enriched protein association networks. Selected genes of high significance were validated using an independent donor cohort. We identified over 50 annotated genes enriched in cell-mediated immune responses that are globally over-expressed in RPE-choroid AMD phenotypes. Using a machine learning model and a second donor cohort, we show that the top 20 global genes are predictive of AMD clinical diagnosis. We also discovered functionally enriched gene sets in the RPE-choroid that delineate the advanced AMD phenotypes, neovascular AMD and geographic atrophy. Moreover, we identified a graded increase of transcript levels in the retina related to wound response, complement cascade, and neurogenesis that strongly correlates with decreased levels of phototransduction transcripts and increased AMD severity. Based on our findings, we assembled protein-protein interactomes that highlight functional networks likely to be involved in AMD pathogenesis. We discovered new global biomarkers and gene expression signatures of AMD. These results are consistent with a model whereby cell-based inflammatory responses represent a central feature of AMD etiology, and depending on genetics, environment, or stochastic factors, may give rise to the advanced AMD phenotypes characterized by angiogenesis and/or cell death. Genes regulating these immunological activities, along with numerous other genes identified here, represent promising new targets for AMD-directed therapeutics and diagnostics. Please see related commentary: http://www.biomedcentral.com/1741-7015/10/21/abstract
CONCLUSION OF VOLUME XV.
Journal: JAMA (1890)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Robert Liston (1794-1847), surgeon of Edinburgh and London
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
In Reply
Authors: Malcolm J. Moore, Wendy Parulekar, Keyue Ding
Journal: Journal of Clinical Oncology (2007)

25; P Ͻ .0001).We found that patients with VTE also had lower chance of achieving a response (P ϭ .04).This analysis indicates that VTEs are frequent and impact negatively on survival and progression-free survival in advanced pancreatic cancer.