tbuckley/cabot-search huggingface dataset:
Archives of Disease in Childhood, London
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Health Values of the Seriously Ill
Authors: Joel Tsevat
Journal: Annals of Internal Medicine (1996)

Letters15 January 1996Health Values of the Seriously IllJoel Tsevat, MD, MPH, David B. Matchar, MD, and Albert W. Wu, MD, MPHJoel Tsevat, MD, MPHUniversity of Cincinnati Medical Center; Cincinnati, OH 45267, David B. Matchar, MDUniversity of Cincinnati Medical Center; Cincinnati, OH 45267, and Albert W. Wu, MD, MPHUniversity of Cincinnati Medical Center; Cincinnati, OH 45267Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-124-2-199601150-00033 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:The time-tradeoff method is a standard value-preference-utility measure that ascertains the desirability of a state of health [1], in this case, the patient's own state of health. It is not necessarily a measure of the "'value' of their lives," as Dr. Letvak states. We do not believe that the time-tradeoff method is biased or leading [1]. Neither do we believe that preferences for cardiopulmonary resuscitation and for life-extending care even at the expense of pain and discomfort represent "true values" of life.Aside from eliciting time-tradeoff utilities, we sought to determine their potential determinants. In response to Dr. ...References1. Torrance GW. Measurement of health state utilities for economic appraisal: a review. J Health Econ. 1986; 5:1-30. Google Scholar2. Tsevat J, Cook EF, Green ML, Matchar DB, Dawson NV, Broste SK, et al. Health values of the seriously ill. Ann Intern Med. 1995; 122:514-20. Google Scholar3. Revicki DA, Kaplan RM. Relationship between psychometric and utility-based approaches to the measurement of health-related quality of life. Qual Life Res. 1993; 2:477-87. Google Scholar4. Tsevat J, Solzan JG, Kuntz KM, Ragland J, Currier JS, Sell RL, et al. Health values of HIV-infected patients: relationship to mental health and physical functioning. Med Care. (In press). Google Scholar5. Tsevat J, Weeks JC, Guadagnoli E, Tosteson AN, Mangione CM, Pliskin JS, et al. Using health-related quality-of-life information: clinical encounters, clinical trials, and health policy. J Gen Intern Med. 1994; 9:576-82. Google Scholar Author, Article, and Disclosure InformationAffiliations: University of Cincinnati Medical Center; Cincinnati, OH 45267 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByPreferences For Prolonging Life: A Prospect Theory Approach 15 January 1996Volume 124, Issue 2Page: 279KeywordsCardiopulmonary resuscitationMathematical models Issue Published: 15 January 1996 CopyrightCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Iron deficiency in the United States
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 587: Ablation of AngiotensinIV Receptor Attenuates Hypofibrinolysis and Inhibits Neointimal Formation in Murine Vascular Injury Model
Authors: Yasushi Numaguchi, Ryuji Kubota, Masakazu Ishii, Xiuyang Ma, Tetsuro Nagasaka, Shigehiko Mizutani, Toyoaki Murohara
Journal: Circulation (2007)

Reduced fibrinolytic activity is associated with adverse cardiovascular events. Recently, it has been shown that angiotensin (Ang) IV receptor (AT4R) regulated fibrinolyasis via plasminogen activator inhibitor-1 (PAI-1) activation. However, it remains unknown how much this Ang IV-AT4R signaling affects the neointimal formation in the reparative process after vascular injury. To investigate if AngIV would inhibit fibrinolysis and promote neointimal formation, we evaluated the degree of proliferation of vascular smooth muscle cells and compared with the role of AT1R using AT1R and AT4R knockout mice ( AT1R − / − and AT4R − / − , respectively). [Methods and Results] AT1R − / − and AT4R − / − showed normal hemostasis patterns including bleeding time if compared with wild type mice (C57BL6/J; WT). To assess fibrinolysis in an acute thrombosis model, renal glomerular fibrin deposition was counted after lipopolysaccharide injection (0.2mg/kg, i.v., n=5). Fibrin deposition was reduced in AT4R − / − as compared to WT and AT1R − / − at 4 hrs (12±3% of total glomeruli, 27±4% and 25±4%, p=0.012 vs. WT). The levels of plasma active PAI-1 antigen measured by ELISA were also reduced in the order of AT4R − / − , AT1R − / − and WT (4.2±0.8*, 8.0±1 and 14±3 ng/mL, *p&lt;0.001vs. WT). For a vascular injury model, neointimal formation was observed over 7 days after carotid artery ligation and cuff placement. In the carotid arteries of WT and AT1R −/− , significant hyperplasia of adventitial tissues and neointimal formation were observed after vascular injury, while those of AT4R −/− were minimally affected (n=6 each) in accordance with greater lumen diameters. In this model, genetic ablation of AT4R, but not AT1R, showed beneficial effects in vascular remodeling. [Conclusions] In murine vascular injury model, disruption of AngIV-AT4R signaling leads to accelerated fibrinolysis and decreased neointimal formation, suggesting that AT4R is a novel therapeutic target against cardiovascular disease. Morphometric Analyses of the Sections from Murine Carotid Arteries
From the Centers for Disease Control. Possible transmission of human immunodeficiency virus to a patient during an invasive dental procedure
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Linkage of the hepatitis C virus genotype and interleukin-28B genetic polymorphisms in Asian patients
Authors: Marco Antonio Montes-Cano, José Raúl García-Lozano, Cristina Abad-Molina, Fuensanta Torrecillas, Almudena Torres, Luis Felipe Lopez-Cortes, Antonio Núñez-Roldán, María Francisca González-Escribano
Journal: Hepatology (2010)

We thank Huang and colleagues for their comments on our article recently published in HEPATOLOGY.1 In this study, we found an overrepresentation of individuals with the interleukin-28B (IL-28B) genotype predictor of sustained virological response (rs12979860CC) among patients infected by non–genotype 1 (non-G1) hepatitis C virus (HCV). In their study, Huang et al. confirmed our results by genotyping another IL-28B single-nucleotide polymorphism, rs8099917 (which is also associated with the response to treatment), in a large Asian HCV cohort that included G2-infected patients at a high rate. We also confirmed our previous results in a new cohort consisting of 182 patients coinfected with human immunodeficiency virus and HCV who had a higher rate of non-G1 infection (48% with G1, 1% with G2, 36% with G3, and 15% with G4). The distribution of IL-28B genotypes among individuals stratified by their viral genotypes was similar to the distribution in the cohort previously reported. Figure 1 displays the results from the mixing of both cohorts; the CC genotype was underrepresented in patients infected by G1 (36%) or G4 (33%) and was overrepresented in patients infected with G2 (85%) or G3 (64%) in comparison with our uninfected population (45%). Thus, both the IL-28B variants and viral genotypes predicting a sustained virological response and the factors predicting an unsustained virological response were found together more often than expected. In conclusion, our results, together with those reported by Huang et al. in their letter and by others,2, 3 draw a scenario in which genetic factors from the host and virus are found to be unexpectedly associated. Although these results are difficult to explain with our current knowledge, it is necessary to take these findings into account because the relationship between the virus and the host genetic background can act as a confounding factor introducing study bias. Rates of the IL-28B rs12979860CC genotype among patients infected with various HCV genotypes (G1-G4). The rates of patients infected with G1 and G4 or G2 and G3 are displayed. A comparison of the G1+G4 group and the G2+G3 group was statistically significant (P = 7.13 × 10−9). Marco Antonio Montes-Cano M.D.*, José Raúl García-Lozano M.D.*, Cristina Abad-Molina M.D.*, Fuensanta Torrecillas M.D.*, Almudena Torres M.D. , Luis Felipe Lopez-Cortes M.D., Ph.D. , Antonio Núñez-Roldán M.D., Ph.D.*, María Francisca González-Escribano Ph.D.*, * Servicio de Inmunología, Hospital Universitario Virgen del Rocío/Instituto de Biomedicina de Sevilla, Seville, Spain, Servicio de Enfermedades Infecciosas, Hospital Universitario Virgen del Rocío/Instituto de Biomedicina de Sevilla, Seville, Spain.
Abstract 3375: leveraging protein dynamics to identify mutational hotspot communities in cancer driver genes
Authors: Sushant Kumar, Declan Clarke, Mark Gerstein
Journal: Cancer Research (2019)

Abstract Large-scale exome sequencing of tumor genomes has enabled the identification of cancer driver genes using recurrence analysis and clustering-based approaches. Some of these methods also employ 3D protein structural data to identify missense mutational hotspots in many cancer-associated genes. However, in determining such mutational clusters in protein structures, a majority of these approaches overlook the role of protein dynamics. In this work, we present a novel framework to identify cancer driver genes using a more sensitive search of mutational hotspot communities on protein structures by incorporating models of protein dynamics. We applied our method to the TCGA pan-cancer atlas missense mutation catalog to identify cancer genes with hotspot mutational clusters within their associated PDB structures. Overall, our analysis predicts one or more mutational hotspot within the resolved structures of known as well as novel cancer driver genes. Ontological enrichment analysis implicates the roles of genes with predicted hotspots in vital biological processes, including cell differentiation, cell proliferation, signal transduction, kinase activity, and nucleotide binding. Furthermore, a comparison between our approach with previous 3D structure-based cancer hotspot detection methods suggests that the including protein dynamics significantly improves the identification of additional putative driver genes. In summary, our proposed framework predicts novel cancer driver genes and provides mechanistic insight into cancer progression through the lens mutational hotspots. Citation Format: Sushant Kumar, Declan Clarke, Mark Gerstein. leveraging protein dynamics to identify mutational hotspot communities in cancer driver genes [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3375.
Post-Transplant Cyclophosphamide Versus Antithymocyte Globulin in Patients with Acute Myeloid Leukemia Undergoing Allogeneic Stem Cell Transplantation from HLA-Identical Sibling Donors: A Retrospective Analysis from the Acute Leukemia Working Party of the EBMT
Authors: Giorgia Battipaglia, Myriam Labopin, Rose-Marie Hamladji, Didier Blaise, Patrice Chevallier, Armin Gerbitz, Gerard Socie, Boris Afanasyev, Fabio Ciceri, Ellen Meijer, Yener Koc, Jan J Cornelissen, Anne Huynh, Hakan Ozdogu, Johan Maertens, Franciane Paul, Hélène Labussière-Wallet, Mahmoud Aljurf, Ali Bazarbachi, Bipin N. Savani, Arnon Nagler, Mohamad Mohty
Journal: Blood (2019)
Involvement of annexin I and annexin II in hepatocyte proliferation: Can annexins I and II be markers for proliferative hepatocytes?
Authors: T Masaki
Journal: Hepatology (1994)

Annexin is the name of a new family of Ca2+-dependent membrane-binding proteins. Eleven types of its related proteins have been reported to date. Among those, annexin I and annexin II have been reported to possess many biological functions in vitro. Its actual role in vivo, however, is yet unknown. The involvement of annexin I and annexin II in the proliferation processes of hepatocytes was examined in the following aspects: (a) hepatocyte proliferation after carbon tetrachloride—induced liver damage, (b) hepatocyte regeneration after partial hepatectomy and (c) postnatal development of hepatocytes. These results showed collectively that annexin I and annexin II were increased in proliferative (or regenerative) hepatocytes, suggesting that both proteins play a certain role in the proliferation event. Furthermore, annexin I—and annexin II—positive hepatocytes always show a wider distribution than that of proliferating cell nuclear antigen or cytokeratin 7—positive hepatocytes, indicating that annexin I and annexin II may be useful markers for detecting not only actively proliferating hepatocytes but also hepatocytes in preproliferative and postproliferative stages. (Hepatology 1994;20:425–435.)
The Cure of Obesity. By Dr. Jean Frumusan.
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bath Thermal Mineral Waters: Their Uses and Abuses
Authors: A. B. Brabazon
Journal: BMJ (1878)

THE BRITISH MEDICAL (OURNAL.407 was being compressed by Heath of Manchester for aneurism of the common femoral, when death resulted from rupture of an unrecognised abdominal aneurism above the point of compression.In my case, the rupture took place into the retroperitoneal tissue ; and, therefore, death did not at once result, but a false aneurism was formed, which attained an enormous size.It is worthy of note, however, that in cases of distal ligature at the root of the neck, there has often not been increased pulsation in the sac, but, on the contrary, a speedy diminution in both the impulse and the size of the aneurism.Thus, while fiiy recognising the risks accompanying distal compression of the aorta, we are justified in adopting this treatment with some hope of success; and more especially because we have to do with a disease that is almost invariably fatal-it may be very speedily-if left to itself.I do not consider that my patient's life was materially shortened by the result of the treat- ment, seeing that he lived seven weeks after it, and that, when it was adopted, the aneurism was making rapid progress and the patient was apparently fast dying from exhaustion.
Increased seizure frequency with generic primidone
Authors: E. Wyllie
Journal: JAMA (1987)

GENERIC drugs produced by different pharmaceutical companies may have different rates of extent of absorption.<sup>1-8</sup>This is particularly important to epileptic patients, because most of the antiepileptic medications have low therapeutic indexes. If a patient switches from an antiepileptic preparation with fairly complete absorption to one with less complete absorption, then the serum drug concentration may drop and the patient could have an increased frequency of seizures. If a patient is switched in the other direction, from a less well-absorbed preparation to one that is better absorbed, then the serum concentrations may rise and the patient could have symptoms of toxic effects. Even if the new product has the same completeness of absorption, there may still be a faster or slower rate of absorption that could affect dosing schedules. These problems have occurred for patients with epilepsy. Previous reports have shown differences in bioequivalence for preparations of phenytoin sodium
Reply to Alessia Cimadamore, Liang Cheng, Antonio Lopez-Beltran, Marina Scarpelli, and Rodolfo Montironi’s Letter to the Editor re: Scott Wilkinson, Huihui Ye, Fatima Karzai, et al. Nascent Prostate Cancer Heterogeneity Drives Evolution and Resistance to Intense Hormonal Therapy. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2021.03.009: Focus on Intraductal Carcinoma of the Prostate
Authors: Scott Wilkinson, Huihui Ye, Rosina T. Lis, Adam G. Sowalsky
Journal: European Urology (2021)
Risks with continuous subcutaneous insulin infusion can be serious
Authors: G Knight
Journal: BMJ (2001)

Mercury sphygmomanometers: disposal has far reaching consequencesEditor-The papers by O'Brien and Beevers et al have documented the trend away from the use of the mercury sphygmomanometer. 1 2 But the ethical, legal, economic, and public health consequences associated with their disposal have not been so well documented.This lack of advice is surprising since mercury has well known toxic properties.Haphazard disposal of mercury inevitably leads to environmental recycling and bioconcentration, with ecological damage at best and human poisoning at worst. 3 The Special Waste Regulations 1996 classify mercury and waste material containing more than 3% mercury as special waste and require extensive documented control of, and the use of approved contractors for, each stage of the disposal process.Noncompliance can result in a major fine, together with a custodial sentence.Although technically only the mercury component is special, it would not be safe for staff to break sphygmomanometers open to access the mercury in uncontrolled conditions.In addition, we considered it likely that standard mercury containing sphygmomanometers used in general prac-tice in England and Wales would contain more than 3% mercury and should therefore be considered special waste.We obtained four intact mercury sphygmomanometers from a general practitioner's surgery and drained and weighed the mercury under laboratory conditions.Each contained more than 3% mercury (average 6.5%).The NHS must develop a policy for the storage and ultimate disposal of retired mercury sphygmomanometers that accords with the Special Waste Regulations 1996.Data from Birmingham health authority show that more than 30 000 mercury sphygmomanometers are still in active use by general practitioners in the UK.If plans are not made to dispose of these sphygmomanometers safely, some 1800 kg of mercury could enter the environment.The contamination that would result from the haphazard disposal of all mercury sphygmomanometers used in the NHS would be much greater, and the volumes involved suggest that collection and recycling may be commercially viable.What should general practitioners, hospitals, and other NHS trusts do?Expecting each to negotiate a suitable system of collection and disposal would be burdensome, inefficient, and impractical, although it is their legal responsibility to do so.We are working with the environment agency in our region to develop an approved scheme that will reduce the bureaucratic demands on individual practices while protecting them from statutory action and, at the same time, provide a safe, efficient, and cost effective storage, transport, and disposal service.