tbuckley/cabot-search huggingface dataset:
Individual Medicine
Authors: Willoughby Lathem
Journal: New England Journal of Medicine (1968)

COMMUNITAS University School of Medicine was a renowned institution. From a modest start, it had, in time, acquired an international reputation for its quality, standards, scholarship, originality and research. It was widely emulated throughout the world and was a focus for advanced training of physicians and other health personnel from many countries. Its staff served on a multiplicity of important national and international organizations and committees, and acted as advisers at the highest level of government. Appointments to the faculty were highly prized and carefully made. Its students were scrupulously selected from a large number of gifted applicants, and as . . .
Recurrent hypoglycaemia in a diabetic patient as a result of unexpected renal failure
Journal: BMJ (2004)

group, 4 but another study showed that virtual groups may be less effective than face to face groups to sustain weight loss. 13In terms of the outcome measures used, future studies should also include measures of resource use, as it is currently not clear whether participation in a peer to peer group reduces or increases the use of health care.Given the abundance of unmoderated peer to peer groups on the internet, researchers must focus their efforts not only on sophisticated professionally led systems, but shift their attention to consumer led, self help venues.Perhaps in this way the research community can best help consumers to help themselves, a guiding principle of support groups regardless of the venue in which they occur.
Variations in interpretation of prescription instructions. The need for improved prescribing habits
Authors: J. M. Mazzullo
Journal: JAMA (1974)

Sixty-seven patients interpreted instructions on each of ten prescription labels. Not once was a label uniformly interpreted by all patients. Besides variability in the interpretation of imprecise instructions, frequent misinterpretation of explicit instructions occurred. With five prescriptions whose instructions were not ambiguous, the frequency of interpretive errors ranged from 9% to 64%. These observations illustrate the need for physicians to provide medication instructions that are consistent with the patient's daily activities and to review these instructions with the patient.
LETTER FROM NEW YORK.
Authors: None P. B. P.
Journal: JAMA (1891)

(FROM OUR OWN CORRESPONDENT.) The health of the city continues to be in a very satisfactory condition. During the week ending September 12th 747 deaths were reported, representing an annual death rate of 23.05 per thousand inhabitants in a population of 1,690,076, against 822, the average number for the same week during the past five years, and the average rate 23.48. This is an increase of 11 on the mortality of the preceding week, and this slight increase was chiefly due to diseases of the respiratory organs. The deaths from this class of diseases were, bronchitis, 25, pneumonia, 51, and phthisis, 102. In contagious diseases there were 24 cases of measles, with one death, 80 cases of diphtheria, with 21 deaths, and 42 cases of typhoid fever, with 9. deaths. Diarrhceal diseases, one fatal in 112 cases, and there were 341 deaths among children under 5 years of age. The
Topical Antihistamines
Authors: P. W. Grant
Journal: British Journal of Dermatology (1968)

Journal Article Topical Antihistamines Get access P. W. Grant P. W. Grant Raigmore Hospital, Inverness Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 80, Issue 5, 1 May 1968, Page 344, https://doi.org/10.1111/j.1365-2133.1968.tb12314.x Published: 01 May 1968
Recent Events of Special Interest to Medical Education
Authors: C. H. William Ruhe
Journal: JAMA (1978)

Since 1966, section I of the EDUCATION ISSUE has been devoted to a review of "Recent Events of Special Interest to Medical Education." Information has been included about special studies, reports, legislation, and other events and activities that are related to medical education and may be expected to influence its future course and direction. During the past year, several important trends were evident. One was growing concern over the cost of medical care, with resultant proposals for cost containment at various points in the system, including medical education. Coupled with rising inflation and taxpayers' revolts against government spending, the desires to restrain expenditures seem certain to increase the fiscal problems of educational institutions. Changes in admission policies and problems were forecast by the Supreme Court's decision on the<i>Bakke</i>case and by a significant downturn in applicants for admission to health schools, the first in many years. Implementation of the
First annual medical alliance month starts today
Authors: Phil Gunby
Journal: JAMA (1995)

THIS IS the first day of the first annual Medical Alliance Month. More than 60 000 women and men are active in Medical Alliance programs in connection with local and state medical societies and the American Medical Association (AMA). Medical Alliance is today's name for what most medical associations once called the Medical Auxiliary. Much of the credit for the month-long observance that begins today, AMA Alliance officials say, goes to Barbara Tippins, the current national president (and wife of an Atlanta, Ga, area obstetrician-gynecologist). Among other goals, this month's effort emphasizes Medical Alliance dedication to public health. <h3>Nationwide Challenges</h3> As Medical Alliance Month gets under way, some 602 alliance initiatives in 36 states are engaged in heightening public awareness of family violence and providing support to its victims. In addition, more than 2200 alliance programs have begun to address the challenges associated with immunization, tobacco addiction, sex education, teenage
Large doses of procainamide for paroxysmal ventricular tachycardia
Authors: R. D. Patton
Journal: JAMA (1969)

Although recurrent ventricular tachycardia can be controlled in many patients with standard doses of procainamide hydrochloride or quinidine sulfate, the occasional patient with a condition refractory to this therapy has been treated with beta- adrenergic blocking agents, cardiac sympathectomy, or pacemakers. In four patients with refractory ventricular tachycardia, 7.5 to 10.5 gm procainamide hydrochloride successfully controlled the arrhythmia without adverse sequelae. Physicians should consider large doses of procainamide before they utilize more radical therapy.
Physiological Principles in Treatment.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
GREATER PNEUMONIA MORTALITY IN FLATS.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Infection control in nursing homes
Authors: P. W. Smith
Journal: JAMA (1985)

Approximately 2.1 million infections occur annually in acute care hospitals and 1.5 million occur in nursing homes, according to estimates by the Centers for Disease Control.<sup>1</sup>Several surveys of nursing homes<sup>2-4</sup>and a recent textbook<sup>5</sup>point out that the risk of developing an infection in a nursing home is comparable to the risk of developing a hospital-acquired infection, about 5% to 10% per year. Nursing home beds are categorized as skilled nursing beds or intermediate care beds. Residents in skilled care beds require more intensive nursing, and presumably have a greater risk of developing an institutionally acquired (nosocomial) infection. However, reliable data on comparative infection rates are lacking. Elderly residents of nursing homes are vulnerable to infections because of an age-related waning of immunity, and because of multiple medical problems (eg, cancer, diabetes mellitus, peripheral vascular disease, and incontinence) and therapeutic interventions (eg, urinary catheters and steroid therapy).
Gastroduodenal Endoscopy with Fiberscope: Analysis of 500 Examinations
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Obituary
Authors: J.S. Pegum
Journal: British Journal of Dermatology (1995)

Journal Article Obituary Get access J.S. Pegum J.S. Pegum Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 132, Issue 1, 1 January 1995, Page 149, https://doi.org/10.1111/j.1365-2133.1995.tb08642.x Published: 01 January 1995
P1.01-015 Crizotinib in ROS1 Rearranged or MET Deregulated Non-Small-Cell Lung Cancer (NSCLC): Final Results of the METROS Trial
Authors: L. Landi, R. Chiari, C. Dazzi, M. Tiseo, A. Chella, A. Delmonte, L. Bonanno, D. Cortinovis, F. De Marinis, G. Minuti, R. Buosi, A. Morabito, G. Spitaleri, C. Gridelli, P. Maione, D. Galetta, F. Barbieri, F. Grossi, S. Novello, R. Bruno, G. Alì, A. Proietti, G. Fontanini, A. Joseph, L. Crinò, F. Cappuzzo
Journal: Journal of Thoracic Oncology (2017)
Absence of Plant Uptake and Translocation of Polybrominated Biphenyls (PBBs)
Authors: S. F. Chou, L. W. Jacobs, D. Penner, J. M. Tiedje
Journal: Environmental Health Perspectives (1978)

Studies of polybrominated biphenyl (PBB) uptake by plants have been conducted in hydroponic solutions and in greenhouse experiments with soil. Autoradiograms of corn and soybean seedlings grown in hydroponic solutions showed no translocation of 14C-PBB from 14C-PBB-treated solutions to plant tops or within the leaf from 14C-PBB-treated spots on the upper leaf surface. A significant portion of the 14C-PBB associated with the roots was removed when the roots were dipped in acetone. Three root crops (radishes, carrots, and onions) were grown in two soils, each treated with a mixture of FireMaster BP-6 (PBB) and 14C-PBB to achieve final concentrations of 100 ppm and 100 ppb. All roots showed more PBB when grown in the soil with the lower clay and organic matter content than they did when grown in the soil with more clay and organic matter. In the latter soil (clay loam) no PBB was detected in any roots from the 100 ppb treatment. More PBB was associated with roots of carrot than of radish or onion. Corn leaf whorls containing dust from a PBB contamination soil and washed radishes from a heavily contaminated garden showed no PBB.
The use of pulse oximetry during conscious sedation. Council on Scientific Affairs, American Medical Association
Authors: Yank D. Coble, A. Bradley Eisenbrey, E. Harvey Estes, Mitchell S. Karlan, William R. Kennedy, Patricia Joy Numann, William C. Scott, W. Douglas Skelton, Richard M. Steinhilber, Jack P. Strong, Christine C. Toevs, Henry N. Wagner, Jerod M. Loeb, Robert C. Rinaldi, Joan B. Vatz
Journal: JAMA (1993)

SINCE its introduction in the early 1980s, pulse oximetry has been one of the most rapidly diffusing electronic monitoring technologies in medicine.<sup>1</sup>Use of pulse oximetry during procedures requiring general anesthesia quickly became standard practice in the United States because it is noninvasive, requires no special training, gives continuous realtime estimates of arterial oxygen saturation (SaO<sub>2</sub>) in the range of 70% to 100%, and gives early warning of loss of pulse.<sup>1-3</sup>This report provides background information concerning the development of oximetry technology and its use during "conscious sedation," a state of minimally depressed consciousness elicited by sedating agents used during certain procedures. <h3>HISTORY</h3> Oximetry originated in Germany in the 1930s with the work of Nicolai, Kramer, and Matthes.<sup>4</sup>They studied the kinetics of tissue oxygenation and applied the Beer Lambert law, which relates the concentration of a solute to the intensity of light transmitted through the
Cimetidine Hypersensitivity
Authors: RUSSELL B. LEFTWICH
Journal: Annals of Internal Medicine (1982)

Letters and Corrections1 October 1982Cimetidine HypersensitivityRUSSELL B. LEFTWICH, M.D., RONALD A. SIMON, M.D.RUSSELL B. LEFTWICH, M.D.Search for more papers by this author, RONALD A. SIMON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-97-4-620_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We wish to comment on the letter on hypersensitivity to cimetidine that appeared in the July issue (1). The patient developed urticaria and angioedema 30 minutes after a third intravenous dose of cimetidine. She had not received this medication previously and the first dose had presumably been administered approximately 12 hours earlier. The authors suggest that the reaction was a type I hypersensitivity reaction to cimetidine. This suggestion would seem untenable because the time needed to develop a primary antibody response is considerably longer than 12 hours and is on the order of days.A pruritic, erythematous,...References1. SANDHUREQUENA BR. Hypersensitivity to cimetidine [Letter]. Ann Intern Med. 1982;97:138. LinkGoogle Scholar2. PRAUSNITZKUSTNER CN. Studien uber Ueberemprindlien-Keit. Zentral B.D. Bakteriol. 1921;86:160. Google Scholar3. VANARDSEL P. Adverse drug reactions. In: MIDDLETON E JR, ed. Allergy Principles and Practice. St. Louis: C. V. Mosby; 1978:11-72. Google Scholar4. LICHENSTEINGILLESPIE LE. Inhibition of histamine release by an H2 receptor. Nature. 1973;244:287-8. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Scripps Clinic and Research Foundation La Jolla, CA 92037 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAdverse Reactions and Interactions with H2-Receptor AntagonistsTHE FIRST REPORT OF CIMETIDINE-INDUCED ANAPHYLAXIS IN JAPANESECimetidine and HypersensitivityBALDEV S. SANDHU, M.B. CH.B., RAMIRO REQUENA, M.D. 1 October 1982Volume 97, Issue 4Page: 620-621KeywordsAntibody productionHypersensitivityUrticaria Issue Published: 1 October 1982 PDF DownloadLoading ...
Government Services
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The significance of human jagged 1 mutations detected in severe cases of extrahepatic biliary atresia
Authors: T Kohsaka
Journal: Hepatology (2002)

Mutations of human jagged 1 (JAG1) gene are responsible for Alagille Syndrome (AGS), whose 2 main symptoms are intrahepatic bile duct hypoplasia and pulmonary stenosis. We examined the JAG1 mutation in extrahepatic biliary atresia (EHBA), which is similar in phenotype to AGS, although a different pathogenesis is suggested. In 102 cases of EHBA, 9 missense mutations were detected, including 2 intrafamilial expressions in the propositus and an aunt of one family. These mutations were all missense and sporadic except for those of this particular family. The JAG1 gene mutations were generally found in severely ill patients subjected to liver transplantation at less than 5 years of age. None of the 9 cases of EHBA revealed any of the 5 major symptoms of AGS nor any identical pathological findings after 3 years of follow-up. Our cases were clearly separated from AGS by pathological findings and clinical features, and could be diagnosed as EHBA and not as atypical AGS. The increase of interleukin 8 (IL-8) production induced by tumor necrosis factor α (TNF-α) in Huh 7 cells was suppressed by the coexistence of JAG1 protein. We examined the different influences between wild-type cells and the 3 kinds of mutants detected in EHBA on Huh 7 cells and found that 2 of 3 mutants showed about half of the repressed activity compared with that of wild type. In conclusion, these results suggest that the JAG1 gene abnormality may be an aggravating factor in EHBA. (HEPATOLOGY 2002;36:904-912.)
Fuller on Male Sexual Disorders. Disorders of the Sexual Organs in the Male
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Contraception
Authors: H. C. McLaren
Journal: BMJ (1954)

Background: Radiation and systemic chemotherapy are standard treatment strategies for advanced or metastatic head and neck cancer. However, little is known about the implications and changes in the tumor microenvironment, including the T-helper (TH)<sub>1</sub>/TH<sub>2</sub> balance in response to these treatment regimens. The aim of the current study was to unravel the effects of chemotherapeutic drugs and radiation on cytokine changes. Materials and Methods: In this study, the effect of radiation and chemotherapeutic treatment (5-fluorouracil and cisplatin) on eight cell lines was determined. Before and after exposure, cytokine levels in culture supernatants of cell lines were evaluated using the Bio-Plex Assay (Bio-Rad) and the Human TH<sub>1</sub>/TH<sub>2</sub> Cytometric Bead Array (Becton Dickinson). Results were correlated with parallel measurements for cellular proliferation assessed by cytotoxicity assay. Results: Seven out of eight cell lines of primary tumors or metastases demonstrated an enhanced level of the cytokines interleukin (IL)-1β, IL-6, IL-8, granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage-colony stimulating factor (GM-CSF) and tumor necrosis factor-α (TNF-α), after sub-lethal radiation doses. Under treatment with low concentrations of 5-fluorouracil and cisplatin, all examined cell lines showed an increasing secretion of the cytokines IL-6 and G-CSF. In contrast, sub-lethal doses of both cytostatic drugs revealed a dose-dependent decrease in secretion IL-1β. Regarding GM-CSF and TNF-α, we demonstrated an increase in secretion by the primary tumors under low doses of 5-fluorouracil and cisplatin, whereas the metastases showed a sharp drop of GM-CSF and TNF-α secretion. Chemotherapeutic treatment led to no changes of the IL-8 cytokine profile. Conclusion: The results suggest complex cytokine changes of the tumor microenvironment and more aberrant expression profiles under treatment with radiation and the chemotherapeutic drugs 5-fluorouracil and cisplatin.