tbuckley/cabot-search huggingface dataset:
BITS OF MEDICAL HISTORY OF PURITAN BOSTON.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A prospective investigation of pulmonary embolism in women and men
Authors: D. A. Quinn
Journal: JAMA (1992)

<h3>Objective.</h3> —The aim of this study was to compare, in women and men suspected of pulmonary embolism, the frequency, risk factors, diagnosis, and presentation of pulmonary embolism as well as the accuracy of the ventilation/ perfusion scan (V/Q scan) as a diagnostic tool. <h3>Design.</h3> —Data were collected during a prospective study (the Prospective Investigation of Pulmonary Embolism Diagnosis) to establish the accuracy of the V/Q scan compared with pulmonary angiograms. <h3>Setting.</h3> —Six tertiary medical centers in Massachusetts, Michigan, Connecticut, Pennsylvania, and North Carolina. <h3>Participants.</h3> —Patients suspected of pulmonary embolism for whom a request was made for a V/Q scan or pulmonary angiogram (496 women and 406 men). <h3>Results.</h3> —Women 50 years old and under had a decreased frequency of pulmonary embolism compared with men of that age (16% vs 32%), but there was no difference in patients over 50 years old (Breslow-Day test,<i>P</i>&lt;.01). Risk factors for pulmonary embolism, the usefulness of the V/Q scan, and 1-year mortality were not different for women and men. Estrogen use in women was not associated with an increased frequency of pulmonary embolism, except in women using oral contraceptives who had undergone surgery within 3 months; four of five (80%) had emboli compared with four of 28 (14%) age-matched surgical patients not using estrogens (<i>P</i>&lt;.01). <h3>Conclusion.</h3> —Women 50 years old and under (even young women using oral contraceptives) who were suspected of having pulmonary emboli and were enrolled in the Prospective Investigation of Pulmonary Embolism Diagnosis study had a smaller frequency of pulmonary embolism than men of that age, The risk factors for pulmonary embolism were the same for women and men, except that women using oral contraceptives had an increased risk of pulmonary embolism following surgery. Although the V/Q scan was a useful tool in the preliminary evaluation for pulmonary embolism in these women, a pulmonary angiogram was often needed for accurate diagnosis. (<i>JAMA</i>. 1992;268:1689-1696)
Current Comment
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The role of tumor necrosis factor-α in acute endotoxin-induced hepatotoxicity in ethanol-fed rats
Authors: J Hansen
Journal: Hepatology (1994)

An in vivo model of ethanol ingestion in rats was used to examine tumor necrosis factor-α production after intravenous injection with lipopolysaccharide or saline solution. Four groups of 125-gm male Sprague-Dawley rats were given one of the following four diets: liquid ethanol diet (ethanol, 36% of calories), liquid control diet, chow ad libitum or control liquid diet pair-fed to match calories consumed by ethanol-fed rats. After 6 wk of diet, all rats were injected with 1 mg/kg lipopolysaccharide or 0.9% saline. AST concentrations in the ethanol-lipopolysaccharide group (388 ± 54 U/ml) were significantly increased compared with those in control-saline, ethanol-saline and control-lipopolysaccharide groups (166 ± 23, 166 ± 18, 219 ± 47; p<0.01). Serum tumor necrosis factor-α concentrations for the ethanol-LPS group (3,990 ± 624 pg/ml) were increased compared with those in control-saline (87 ± 18), ethanol-saline (68 ± 24) and control-LPS (695 ± 165) groups (p<0.001). A strong correlation was seen between serum tumor necrosis factor-α and AST concentrations (r=0.91, p<0.001). Treatment with lipopolysaccharide also increased transcriptional levels of tumor necrosis factor-α-specific mRNA from hepatic Kupffer cells isolated from rats fed the long-term ethanol diet by a factor of 3 compared with control rats. From these data, we conclude that long-term ethanol administration sensitized hepatic Kupffer cells to secrete high levels of tumor necrosis factor-α after lipopolysaccharide injection. Increased serum tumor necrosis factor-α concentrations correlated directly with increased levels of serum transaminase, which may have reflected hepatic injury. (Hepatology 1994;20:461–474.)
Conversations on the social services.
Authors: V Kale, D Woodward, George Hospital, J Chadda
Journal: BMJ (1974)

affected bowel was resected.The patient was given massive doses of steroids, antibiotics, and fluid replacement for septicaemic shock and gradually recovered.Clinical features of myxoedema were then apparent and this was confirmed by iodine studies.The patient's appearance and bowel habit returned to normal with thyroxine.Histologically, the resected bowel showed features of acute ischaemic colitis.Constipation and albdominal distension are well-recognized features of hypothyroidism.Gross colonic dilatation in this patient was followed by mucosal ischaemia and necrosis, allowing the development of septicaemic shock secondary to invasive infection.The usually fatal outco.me in this condition was avoided by prompt excision of the diseased bowel and intensive therapy for septicaemic shock.-Weare, etc.,
ERRATUM
Journal: Journal of Clinical Oncology (2007)

In the Results section, under HRQL, the third to last sentence gave the 1-year QRLS score for FU as 8.3, whereas it should have been 8.4.In Table 3, the column headings for all time points were inadvertently switched, so that those labeled FU should have been UFT, and those labeled UFT should have been FU.Also, the QRLS score for 52 weeks was given as 8.3 for UFT, whereas it should have read 8.4 for FU.The corrected table is reprinted below in its entirety.
Racial/Ethnic Disparities in Self-Rated Health Status Among Adults With and Without Disabilities—United States, 2004—2006
Journal: JAMA (2008)

Self-rated health status has been found to be an independent predictor of morbidity and mortality, and racial/ethnic disparities in self-rated health status persist among the U.S. adult population. Black and Hispanic adults are more likely to report their general health status as fair or poor compared with white adults. In addition, the prevalence of disability has been shown to be higher among blacks and American Indians/Alaska Natives (AI/ANs) (3). To estimate differences in self-rated health status by race/ethnicity and disability, CDC analyzed data from the 2004-2006 Behavioral Risk Factor Surveillance System (BRFSS) surveys. This report summarizes the results of that analysis, which indicated that the prevalence of disability among U.S. adults ranged from 11.6% among Asians to 29.9% among AI/ANs. Within each racial/ethnic population, adults with a disability were more likely to report fair or poor health than adults without a disability, with differences ranging from 16.8 percentage points among Asians to 37.9 percentage points among AI/ANs. Efforts to reduce racial/ethnic health disparities should explicitly include strategies to improve the health and well being of persons with disabilities within each racial/ethnic population.
Impact of contrast agent type (nonionic vs. ionic) used for coronary angiography and PCI on angiographic, electrocardiographic, and clinical outcomes following thrombolytic administration in acute MI Sabina A. Murphy, Ajay J. Kirtane, Susan J. Marble, Kristin C. Schuhwerk, James de Lemos, C. Michael Gibson. University of California San Francisco, San Francisco, CA, Brigham and Women's Hospital, Boston, MA
Journal: Journal of the American College of Cardiology (2001)
<i>The Defective Delinquent and Insane. The Relation of Focal Infections to their Causation, Treatment and Prevention.</i> By Henry A. Cotton, M. D. With a Foreword by Adolf Meyer, M. D. (<i>Princeton, N. J., Princeton University Press, 1921.</i>)
Authors: E. D. B.
Journal: American Journal of Psychiatry (1922)
<i>Clinical Psychiatry</i>. A Text-book for Students and Physicians, abstracted and adopted from the Sixth German Edition of Kraepelin's "Lehrbuch der Psychiatrie." By A. Ross Defendorf, M. D., Lecturer in Psychiatry in Yale University. (New York: The MacMillan Co.; London: MacMillan &amp; Co., Ltd., 1902.) All rights reserved
Journal: American Journal of Psychiatry (1902)
Continuous Flow Blood Cell Separator
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE TREATMENT OF AMEBIASIS
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE BORDERLAND IN MEDICAL LIBRARIES.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A randomized controlled trial comparing modified gemcitabine plus oxaliplatin (mGEMOX) to gemcitabine plus cisplatin in management of unresectable gall bladder cancer.
Authors: Atul Sharma, Surendra Pal Chaudhary, N. K. Shukla, BK Mohanti, S. V. S. Deo, Sujoy Pal, Sanjay Thulkar, Sreenivas Vishnubhatla, Rakesh Kumar, Venkateswaran K Iyer, Vinod Raina
Journal: Journal of Clinical Oncology (2014)

TPS4152 Background: Gemcitabine and platinum compound have become preferred regimen for treatment of advanced/unresectable gall bladder cancer (Best supportive care compared with chemotherapy for unresectable gall bladder cancer:A randomized controlled study. Sharma A, Dwary A D, Mohanti B K,et al. J Clin Oncol. 2010; 28: 4581-4586; Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer. J W Valle, H S Wasan, D D Palmer, et al. N Eng J Med. 2010; 362:1273-81). This ongoing equivalence study has been planned to see whether the combination of gemcitabine and oxaliplatin (mGEMOX) is equivalent to gemcitabine and cisplatin (GemCis). Methods: Primary end point of the study is overall survival in subjects receiving mGEMOX or GemCis regimen. Secondary end points are: A-Comparison of progression free survival in 2 groups, B- Response rates in two groups,C-Identification of genes predictive of responses in a subset of patients, D-To evaluate role of PET CT in GBC patients predicting disease activity Sample size was calculated taking median survival of 9.5 months in our previous study with mGEMOX and 11.7 months with GemCis. For this total of 216 patients are required (108 in each arm); to make for major protocol violation and lost to follow up additional 22 patients in each arm will be enrolled. Thus in total 260 patients (130) in each arm will be recruited. This will have alpha and beta values of 0.05 and 0.20 respectively. So far 152 patients have been enrolled. Treatment protocol: Cycles will be repeated every 3 weeks Arm A- mGEMOX Inj Oxaliplatin 80 mg/m2 2 hours infusion in Dextrose 5% Day 1 and 8 Inj Gemcitabine 900 mg/m2 IV 30 minutes infusion day1 and 8 maximum of 6 cycles Arm B- GEMCIS Inj Cisplatin 25 mg/m2 PO Days 1 and 8 Inj Gemcitabine 1,000 mg/m2 IV 30 minutes infusion day 1 and 8 maximum of 8 cycles. Clinical trial information: CTRI/2010/091/001406.
From the Food and Drug Administration
Authors: S. L. Nightingale
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
To <i>JAMA</i> Peer Reviewers and Authors— Thank You
Authors: Phil B. Fontanarosa, Catherine D. DeAngelis
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Review of Pulmonary Effects of Poly(Vinyl Chloride) and Vinyl Chloride Exposure
Authors: Ruth Lilis
Journal: Environmental Health Perspectives (1981)

The contributions of several recent reports to the definition of pulmonary effects of PVC dust inhalation are reviewed. Granulomatous reaction, with inclusion of PVC particles in macrophages and histocytes, and associated interstitial pulmonary fibrosis have been found to lead to exertional dyspnoea, diffuse micronodular chest radiographic opacities and restrictive pulmonary dysfunction. The effects of vinyl chloride (VC) monomer (gas) on proteins and the immunologic mechanisms triggered by the altered protein are possible mechanisms for the development in some cases of interstitial pulmonary fibrosis secondary to VC exposure. Vinyl chloride, a confirmed carcinogen, has been associated with, among other malignant tumors, a significant increase in the incidence of lung cancer. The magnitude of this effect has not yet been completely evaluated.
Ablation par radiofréquence guidée par écho endoscopie pour les tumeurs neuroendocrines et les cystadénomes pancréatiques: une étude prospective multicentrique
Journal: Endoscopy (2019)

Cette étude a été menée dans le cadre d'une étude prospective de phase I multicentrique, ouverte, non randomisée, sur patients patients présentant des TNE ou des lésions mucineuses afin d’évaluer la morbidité et l’efficacité d’un traitement par radiofréquence guidée par voie endocavitaire sous échoendoscopie.
Tobacco dependence and the nicotine patch. Clinical guidelines for effective use
Authors: M. C. Fiore
Journal: JAMA (1992)

<h3>Objective.</h3> —A comprehensive review of transdermal nicotine treatment for tobacco dependence, with recommendations derived from the research literature. <h3>Data Sources.</h3> —English-language clinical trials. <h3>Study Selection.</h3> —Clinical trials using placebo-controlled, double-blind methodology (11 studies) with at least 6 months of follow-up after treatment (eight studies) and biochemical verification of smoking status. <h3>Data Synthesis.</h3> —Nicotine patches produce end-of-treatment smoking cessation rates that range from 18% to 77%; these rates are about twice those of placebo-treated subjects. Nicotine patches produced 6-month abstinence rates of 22% to 42%, while placebo patches produced quit rates of 5% to 28%. Nicotine patches appear to reduce some, but not all, nicotine withdrawal symptoms. For instance, while the patch reduces craving for cigarettes and negative moods, it does not appear to reduce hunger or weight gain. The clinical trials literature suggests that proper adjuvant smoking cessation counseling is crucial in determining successful long-term outcome with the nicotine patch, and suggests that 6 to 8 weeks of patch therapy may be an adequate duration for most patients. <h3>Conclusions.</h3> —Nicotine patches are an effective aid to tobacco dependence treatment. However, success rates vary greatly across research studies and may be influenced highly by the nature and intensity of adjuvant smoking cessation counseling. More research is needed to identify optimal duration, dosage, and individualization of patch therapy. The impact of nicotine patches (more than 5 million users with $1 billion in sales for 1992) also raises important ethical and public health issues. (<i>JAMA</i>. 1992;268:2687-2694)
A Clinical Lecture ON WHEN TO OPERATE FOR APPENDICITIS
Authors: R. P. Rowlands
Journal: BMJ (1910)

It is certain that a great many people die of appendicitis who could be saved by timely operation, and that we in England err on the side of conservatism, Whereas it is probably true that some American surgeons go to the other extreme.What a pity that we cannot lay down absolute rules which would always guide us to take the right course; but in this, as in oth4er branches of surgery, no such laws can be made because of a variety of circum- stances.Diagnosis is difficult; patients may grin and bear in silence, or refuse to be guided, and a skilful surgeon may not be available at short notice.In this lecture I propose to give my own opinions, formed after some years' experience.A.-AFTER ONE ATTACK.Most physicians and surgeons are now of opinion that it is wise to remove the appendix after one attack of appendicitis.It is certainly true that one attack does not usually protect against another; it nearly always predis- poses.Moreover, it is never certain that a second or subseuent attack may be trivial like the first.The