tbuckley/cabot-search huggingface dataset:
Aberrant Expression and Function of Gap Junctions during Carcinogenesis
Authors: H. Yamasaki
Journal: Environmental Health Perspectives (1991)

Gap junctional intercellular communication plays a key role in the maintenance of homeostasis in multicellular organisms. Reflecting deranged homeostasis in cancer cells, most transformed or cancerous cells show aberrant gap junctional intercellular communication; they have decreased junctional communication between each other and/or with surrounding normal cells. Studies with in vitro cell transformation and animal carcinogenesis models suggest an involvement of blocked intercellular communication in later stages of carcinogenesis. Analysis of expression of gap junction proteins (connexins) and corresponding mRNA indicates that a number of regulation sites are involved in aberrant function of gap junctions during carcinogenesis. Suppression of transformed phenotypes is often seen when transformed cells are physically in contact with their normal counterparts. Some studies suggest that gap junctional intercellular communication is involved in such tumor suppression.
BERLIN
Journal: JAMA (1924)

<h3>Physicians and the Health Insurance Societies</h3> January 4, renewed negotiations for a settlement of the question of medical assistance took place in the federal ministry of labor. The proposal of the physicians to restore former contract conditions was rejected by the health insurance societies. Thereupon the representative of the federal ministry of labor called the attention of both parties to their obligations toward one another as laid down in the Berlin agreement of Dec. 23, 1913, to which I have already referred. According to this agreement, which has the force of law, after cancelation of a contract between physicians and health insurance societies, the conditions of the old contract remain binding on both parties until a new contract has been entered into. The representatives of the physicians were, for the most part, willing to accept this view, but the health insurance societies denied obligation of the health insurance societies to
Racial and ethnic differences in outcome in zidovudine-treated patients with advanced HIV disease. Zidovudine Epidemiology Study Group
Authors: P. J. Easterbrook
Journal: JAMA (1991)

<h3>Objectives.</h3> —To determine if racial-ethnic differences exist in survival, disease progression, and development of myelosuppression in zidovudine-treated patients with advanced human immunodeficiency virus (HIV) disease. <h3>Design.</h3> —Prospective observational study. <h3>Setting.</h3> —Hospital and private clinics in 12 metropolitan centers. <h3>Patients.</h3> —The study included 754 non-Hispanic white, 165 black, and 106 Hispanic patients with the acquired immunodeficiency syndrome (AIDS) or advanced AIDS-related complex (ARC) who received up to 2 years of zidovudine therapy. <h3>Outcome Measures.</h3> —Survival, development of<i>Pneumocystis carinii</i>pneumonia (PCP), other opportunistic infections, and myelosuppression. <h3>Results.</h3> —At initiation of zidovudine therapy, Hispanic and particularly black patients had more advanced HIV disease than white patients, as indicated by lower baseline CD4<sup>+</sup>counts, hematocrits, and AIDS-defining diagnoses. Black patients with AIDS also had a worse prognosis compared with white and Hispanic patients with AIDS. The product-limit survival rates at 2 years for white, black, and Hispanic patients with AIDS were 40%, 27%, and 39%, respectively (black vs white,<i>P</i>=.01; Hispanic vs white,<i>P</i>=.32, by the log-rank test). The respective proportions of patients who developed PCP at 2 years were 46%, 66%, and 44% (black vs white,<i>P</i>=.0001; Hispanic vs white,<i>P</i>=.86) and for other opportunistic infections the proportions were 56%, 63%, and 63%, respectively (black vs white,<i>P</i>=.03; Hispanic vs white,<i>P</i>=.09). There were no significant racial-ethnic differences in survival or in the development of opportunistic infections for patients with ARC, and there were no differences in the incidence of myelosuppression or dose reduction or suspension for patients with either ARC or AIDS. After adjusting for more advanced HIV disease (mainly low CD4<sup>+</sup>counts and hematocrits), black race was no longer a significant independent predictor of survival. Adjustment for racial differences in the use of PCP prophylaxis accounted for most of the excess risk for the development of PCP in black patients compared with white patients with AIDS. <h3>Conclusions.</h3> —Racial differences in survival and the development of opportunistic infections are mainly due to the more advanced HIV disease in black patients when zidovudine therapy is started and to their less frequent use of PCP prophylaxis. Innovative approaches are needed to ensure more widespread use of and earlier access to zidovudine therapy and PCP prophylaxis. (<i>JAMA</i>. 1991;266:2713-2718)
THE NEW AMERICAN MEDICAL DIRECTORY
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Progress in the water story.
Journal: BMJ (1978)

this feature is not inevitable.Equally, leakage may occur when the swelling of the optic disc is due to other causes.'4Parsons's papilloedema is therefore not a single pathological entity but is composed of a number of recognisable elements.Because it is initiated by generalised swelling of the brain it is nearly always bilateral.The raised tissue pressure within the swollen optic nerve leads to disturbance of several intra- neural low-pressure flow systems and in certain circumstances may threaten the microcirculation of the optic nerve.'5
Leads from the MMWR. Enterically transmitted non-A, non-B hepatitis--East Africa
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Book Review . . . And a Time to Die: How American Hospitals Shape the End of Life By Sharon R. Kaufman. 400 pp. New York, Scribner, 2005. $28. 0-7432-6476-2 Physician-Assisted Dying: The Case for Palliative Care and Patient Choice Edited by Timothy E. Quill and Margaret P. Battin. 342 pp. Baltimore, Johns Hopkins University Press, 2004. $49.95 (cloth); $26.95 (paper). 0-8018-8069-6 (cloth); 0-8018-8070-X (paper).
Authors: James L. Bernat
Journal: New England Journal of Medicine (2005)
Obituary
Authors: Bruce B. Dan
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Domestic Abstracts
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AMENORRHEA AND BRAIN TUMOR.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Lecture on the Theory of Construction of the Nervous System
Authors: W. H. Broadbent
Journal: BMJ (1876)

GrNT1,EMFiN,-The shiortness of the timie at miy disposal saves mec PR trouble in one respect, hy rendering impossible any introdluctor-y re- R mark,s.I eniter, therefore, at once uploni the subject auniouttiieed the.Theory of Constr-uctioni of the Nervous System.The wordI thieory is not altogethler free fiomu objection, as hiere enmployndI ; buit, as thle facts ANA of structure have to be interpretedI by experiment, the conicluisions Fio-and -2.-PR antl A\, rrpet ent ti itrioIr aid In r reached, however definite and certain they may uiltimiately becOme, canl PN and ANtheir re,;pective nervses.PR1 an, :\R ir- .ypi.cessrs for reflex actior.'rorn PR upd stward-~ti: -i rhc tr ist scarcely be otlier than a tlleory.Tii AR dlcscendts the inotor tract MI. iot..i~iii . IIIIWe must begin as usual wvith the spinal cord, whiichi is tiaiCtnels.iraitils for rc:lex actioDn t-, aaice [ioms instrument of the brain andI the meduium of communication between it and thle outer world, but offers, in its lplan of construiction, a key to the direct the motor manifestations.Thle pre(lotoi-inace of tii.sensorv more comiplex structure of the higher centres.The spinal corcl, as is side of the nervouis apparatus over tie nvtur iswi~th'- Ic borneii iii well knowi, is at the same time an iindependlent centre for reflex mind.action, and the channel by whichi sensory itupre~ssions, are tranusmitteud 'lie channel of voluntary mlotor-inWilusc' ii tlh., ckri i-fiiu,( b)y
Herpesvirus infections in the acquired immune deficiency syndrome
Authors: G. V. Quinnan
Journal: JAMA (1984)

Herpesvirus infections were studied in persons with or at risk for the acquired immune deficiency syndrome (AIDS). The infections diagnosed were as follows: patients with AIDS, cytomegalovirus (CMV) in 34 of 34, Epstein-Barr virus (EBV) in 33 of 34, herpes simplex viruses (HSV) in eight of 34, and varicella zoster virus in four of 34; patients with chronic lymphadenopathy syndrome, CMV in eight of nine and EBV in nine of nine; in healthy homosexual men, CMV in five of 13 and EBV in seven of eight. Cytomegalovirus infections were frequently related to disease and death. Herpesvirus infections are frequent causes of serious diseases in AIDS. The prevalence of EBV and CMV infections in AIDS and the chronic lymphadenopathy syndrome may be the result of an important interaction between these viruses and the cause of AIDS. (<i>JAMA</i>1984;252:72-77)
The care of patients with oral cavity and lip cancer. Surgical principles
Authors: E. L. Frazell
Journal: JAMA (1971)

Both surgery and irradiation have a role in the treatment of mouth cancer. Alone or in combination, they are the only effective means currently available. Depending on the facilities at hand and the experience and skill of the clinician, small lesions (3 cm or less) may be successfully treated by either local surgery or local irradiation. High cure rates may be expected in almost equal numbers by either method.<sup>6</sup>Their relative merits are not the subject of this discussion. In a significant portion of patients with oral cancer—the majority in our experience — the initial clinical presentation is unfavorable. Extensive infiltration at the primary site plus invasion of adjacent structures lessens the chance of local control of the disease by either irradiation alone or surgery alone. Likewise, clinical evidence of regional lymph node spread indicates a poor prognosis. Just how poor it is is seldom appreciated.<sup>7</sup> The shortcomings
Abstract 12908: Effects of Metabolic Syndrome on In-Stent Restenosis After PCI: Obesity Paradox and Sex-Associated Differences
Authors: Kenji Sakamoto, Naohiro Komura, Kenichi Tsujita, Kenshi Yamanaga, Noriaki Tabata, Tomonori Akasaka, Takashi Miyazaki, Eiichiro Yamamoto, Sunao Kojima, Koichi Kaikita, Sunao Nakamura, Seiji Hokimoto, Hisao Ogawa
Journal: Circulation (2015)

Background: The impact of metabolic syndrome (MetS) on the efficacy of PCI remains controversial. Hypothesis: This controversy may be due in part to a positive influence of obesity (the “obesity paradox”) among the factors included in the definition of MetS. Fat distribution also varies by sex, possibly confounding the impact of obesity. Methods: To elucidate the possible effects of obesity in MetS patients on in-stent restenosis (ISR) or target lesion revascularization (TLR), 546 patients treated with coronary stents (BMS or DES) were stratified according to the presence of MetS with or without obesity, using NCEP-ATP III guidelines. Waist circumference or BMI (in patients without waist circumference data) was used for diagnosis of obesity. Follow-up angiography was scheduled 8 to 9 months after PCI to obtain ISR, which was defined as %diameter stenosis (%DS)&gt;50%. Results: Mean age of the subjects was 70.5±9.8 years, and 32.1% were female. By standard criteria, 286 patients (52.4%) were diagnosed as MetS, and 320 patients (58.6%) met criteria for obesity. Among MetS patients, 61 patients (21.3% of MetS patients) were categorized as non-obesity. At 8 to 9 months follow-up, % DS, ISR rates, and TLR rates had trends to be higher in MetS than no-MetS (ISR; 26.6% in MetS, 20.0% in non-MetS, p=0.085). These parameters showed no difference between obesity and non-obesity (ISR; 23.8% in obesity, 23.0% in non- obesity, p=0.918, TLR; 14.1% in obesity, 15.0% in non-obesity, p=0.805). In patients with MetS (Figure), however, the ratio of %DS and ISR were significantly greater in the absence of obesity in female patients, whereas no difference was observed in male patients. In multivariate analysis, non-obesity was an independent predictor for ISR or TLR in female patients with MetS. Conclusions: Overall, obesity was not related to ISR or TLR after PCI. In female MetS patients, however, comorbidity of obesity appeared to be paradoxically protective.
Medical News
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Immunopharmacology
Authors: John W. Hadden
Journal: JAMA (1987)

IMMUNOPHARMACOLOGY involves the study of the regulation of the immune system and of methods that selectively modify immune function in the treatment of human diseases. The earliest origins of immunotherapy lie in the development of the vaccines that today are the mainstay of specific immunoprophylaxis for cholera, poliomyelitis, smallpox, tetanus, diphtheria, measles, pertussis, influenza, and mumps. The future will see effective vaccines for hepatitis, gonorrhea, cytomegalovirus, and herpesvirus. Novel approaches, using modified antigens, may lead to future vaccines yielding specific tolerance for transplantation alloantigens and allergens or yielding resistance to certain cancers and even to the acquired immunodeficiency syndrome (AIDS). With the definition of the immunoglobulins, the administration of γ-globulins followed naturally in the 1950s for treatment of agammaglobulinemia, for hepatitis prophylaxis, and for immunization with live attenuated virus vaccines. The elucidation of the severe combined immunodeficiency disease brought bone marrow transplantation, now a successful and currently accepted treatment for
Books Received
Journal: JNCI Journal of the National Cancer Institute (1976)

Books Received Get access Clinical Implications of Air Pollution Research (Finkel AJ, Duel WC, eds.). Acton, Massachusetts, Publishing Sciences Group Inc., 1975, $20.00, 400 pp. Colo-Rectal Cancer (Weisburger JH, Reddy BS, Joftes DL, eds.). Monthey, Switzerland, Imprimerie Montfort International Union Against Cancer, 1975, 143 pp. Cancer Detection and Prevention: Proceedings of the Second International Symposium, Bologna, April 9–12, 1973 (Burch PR, Chesters MS, Maltoni C, eds.). Amsterdam, Excerpta Medica; New York, Elsevier, 1974, 661 pp. Smith EA: A Comprehensive Approach to Rehabilitation of the Cancer Patient. Houston, University of Texas Health Science Cente, 1975, 234 pp. Dunn TB: The Unseen Fight Against Cancer. Experimental Cancer Research: Its Importance to Human Cancer. Charlottesville, Va., Bates, 1975, 204 pp. Bostock DE, Owen LN: A Colour Atlas of Neoplasia in the Cat, Dog, and Horse. London, Wolfe Medical Publications; Chicago, Year Book Medical Publishers, 1975, 144 pp. Unclassifiable Leukemias: Proceedings of a Symposium, Paris, October 11–13, 1974 (Baccarini M., ed.). Berlin, Springer-Verlag, 1975, 267 pp. Fundamental Aspects of Neoplasia (Bishop DH, Gottlieb AA, Plescia OJ, eds.). New York, Springer-Verlag, 1975, 424 pp. Characterization of Human Tumors: Proceedings of the Fifth International Symposium on the Biological Characterization of Human Tumors, Bologna, April 4–6, 1973 (Burch PR, Davis W, Maltoni C., eds.). Amsterdam, Excerpta Medica; New York, Elsevier, 1974, 335 pp. Clinical Cancer Chemotherapy (Greenspan EM., ed.). New York, Raven Press, 1975, 414 pp. Proceedings of the Symposium on Chemical Carcinogens, June 28-29, 1973, Pittsburgh, Industrial Health Foundation, 1973, 151 pp. Early Breast Cancer: Detection and Treatment (Gallager HS, ed.). New York, Wiley, 1975, 231 pp. Seydel HG, Chait A, Gmelich JT.: Cancer of the Lung. New York, Wiley, 1975, 200 pp. Immunological Aspects of Neoplasia: A Collection of Papers Presented at the Twenty-sixth Annual Symposium on Fundamental Cancer Research, Houston, Texas, 1973. Baltimore, Williams and Wilkins, 1975, 733 pp. JNCI: Journal of the National Cancer Institute, Volume 56, Issue 5, May 1976, Page CO3, https://doi.org/10.1093/jnci/56.5.CO3 Published: 01 May 1976