Thyroxine Preparations
Authors: JAMES V. HENNESSEY
Journal: Annals of Internal Medicine (1984)

Letters and Corrections1 July 1984Thyroxine PreparationsJAMES V. HENNESSEY, M.D., LEONARD WARTOFSKY, M.D.JAMES V. HENNESSEY, M.D.Search for more papers by this author, LEONARD WARTOFSKY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-101-1-140 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Over the past decade a minor controversy has raged among thyroidologists in regard to the reasons underlying the observed variations in serum thyroxine concentrations in patients taking different preparations of synthetic L-thyroxine (1-3). The clinical significance of such variation lies in the risk of either iatrogenic thyrotoxicosis on the one hand or inadequate thyrotrophin suppression (in patients with history of thyroid cancer) on the other. Possible explanations for the observed variation have included differences in tablet content or methods of formulation that could influence tablet dissolution and, ultimately, bioavailability. In the May issue of theAnnals, Sawin...References1. RAMOS-GABATINJACOBSONYOUNG AJR. In vivo comparison of levothyroxine preparations. JAMA. 1982;247:203-5. CrossrefMedlineGoogle Scholar2. LEBOFFKAPLANSILVALARSEN MMJP. Bioavailability of thyroid hormones from oral replacement preparations. Metabolism. 1982;31:900-5. CrossrefMedlineGoogle Scholar3. INGBARBORGESIFLAHKLEINMANBRAVERMANINGBAR JMHRLS. Elevated serum thyroxine concentration in patients receiving "replacement" doses of levothyroxine. J Endocrinol Invest. 1982;5:77-85. CrossrefMedlineGoogle Scholar4. SAWINSURKSLONDONRANGANATHANLARSEN CMMCP. Oral thyroxine: variation in biologic action and tablet content. Ann Intern Med. 1984;100:641-5. LinkGoogle Scholar5. STOFFERSZPUNAR SW. Potency of levothyroxine products. JAMA. 1984;251:635-6. CrossrefMedlineGoogle Scholar1. STOFFERSZPUNAR SW. Potency of brand name and generic levothyroxine products. JAMA. 1980;244:1704-5. CrossrefMedlineGoogle Scholar2. STOFFERSZPUNAR SW. Potency of levothyroxine products. JAMA. 1984;251:635-6. CrossrefMedlineGoogle Scholar3. SAWINSURKSLONDONRANGANATHANLARSEN CMMCP. Oral thyroxine: variation in biologic action and tablet content. Ann Intern Med. 1984;100:641-5. LinkGoogle Scholar1. SAWINSURKSLONDONRANGANATHANLARSEN CMMCP. Oral thyroxine: variation in biologic action and tablet content. Ann Intern Med. 1984;100:641-5. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Walter Reed Army Medical Center Washington DC 20307 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe emergence of levothyroxine as a treatment for hypothyroidismIn Vitro Dissolution and In Vivo Bioavailability of Commercial Levothyroxine Sodium Tablets in the Hypothyroid Dog ModelThe Equivalency of Two L-Thyroxine PreparationsJAMES V. HENNESSEY, M.D., MAJ, KENNETH D. BURMAN, M.D., LTC, LEONARD WARTOFSKY, M.D., COL 1 July 1984Volume 101, Issue 1Page: 140-141KeywordsAttentionThyroidThyroid carcinomaThyroxine Issue Published: 1 July 1984 PDF downloadLoading ...