tbuckley/cabot-search huggingface dataset:
From Muskegon, Michigan.
Authors: None F. W. G.
Journal: JAMA (1889)

<h3>To the Editor:</h3> —A new medical club has recently been organized at this place. Its membership will be limited to a specified number. It begins with a charter membership of seven, as follows: Drs. J. P. Stoddard, J. M. Cook, O. C. Williams, C. P. Donelson, J. VanderLaan, G. S. Williams, and F. W. Garber. Dr. VanderLaan has been made president, and Dr. Garber secretary and treasurer. Meetings will be held bi-monthly. The first regular meeting will be held Tuesday, January 22. Twenty-eight cases of diphtheria have been reported to the Health Officer since December 1, 1888. These, together with the cases not reported, would make about forty cases within that time. With but one or two exceptions, the disease has manifest itself in a very mild form. Three deaths only have been reported. Muskegon, Mich., January 14.
Phase I Multicenter Trial of Brentuximab Vedotin for Steroid Refractory Acute Graft-Vs.-Host Disease (GVHD)
Authors: Yi-Bin Chen, Shuli Li, Sarah Konkel, Colleen Loiselle, Yvonne A. Efebera, Steven M. Devine, Areej El-Jawahri, Steven L. McAfee, Robert J. Soiffer, Jerome Ritz, Corey S Cutler, Miguel Perales
Journal: Blood (2015)
POISONING BY WOOD ALCOHOL.CASES OF DEATH AND BLINDNESS FROM COLUMBIAN SPIRITS AND OTHER METHYLATED PREPARATIONS.
Authors: FRANK BULLER
Journal: JAMA (1904)

These additional cases of death and blindness from the ingestion of methyl alcohol, collected by Dr. Wood, demonstrate that the baleful influence of the poison is still on us in undiminished force. The form of the drink has, as might be expected, assumed a variety in keeping with its extended employment. Thus we find that in some hitherto unpublished instances the victims drank, in addition to the commoner forms of wood spirits, methylated "essence of peppermint," numerous patent medicines whose chief menstruum was "deodorized" methyl alcohol, "eau de cologne," "Florida water," "bay rum," "witch hazel," lemon "extract," "punch," "high-balls," "hot drops," and red ink. In other respects the histories parallel those collected by Dr. Buller. We propose to use the histories thus made available for a few additional remarks on the general subject of methyl alcohol intoxication. <h3>TOTAL NUMBER OF METHYL ALCOHOL VICTIMS.</h3> From Dr. Buller's tables of
CLINICAL MICROSCOPY.
Authors: W. B. LA FORCE
Journal: JAMA (1895)

In presenting a paper on the subject of scientific medicine and the microscope, I have no discoveries to reveal, nor shall I attempt to review the progress in the science of medicine brought about through the revelations of the microscope; but rather will I direct your attention to its clinical value. With this in view, we will omit detailed reference to the important facts revealed by studying the minute anatomy of the different organs in both their normal and diseased conditions. It is axiomatic that the more we know of the structure, both macroscopic and microscopic, of organs healthy or diseased, the more capable are we to understand the physiologic and pathologic processes which occur in those organs or tissues; and so we will not dwell on those points. Moreover a large part of such knowledge has been acquired through study of the post-mortem specimen. But to-day I desire to
Changes to Wording and Descriptions Throughout Text
Journal: JAMA Internal Medicine (2018)

In the Original Investigation titled "Intra-aortic Balloon Pump Therapy for Acute Myocardial Infarction: A Meta-analysis," published in the June 2015 issue of JAMA Internal Medicine, 1 the positive and negative numbers on the x-axis of Figure 5 were transposed.The numbers should read from 0 to 5 on the left side of the axis and from 0 to -5 on the right side.This article was corrected online.
Re: Michal Sarfaty, Moshe Leshno, Noa Gordon, et al. Cost Effectiveness of Nivolumab in Advanced Renal Cell Carcinoma. Eur Urol. In press. http://dx.doi.org/10.1016/j.eururo.2017.07.041
Authors: Jacopo Giuliani, Andrea Bonetti
Journal: European Urology (2017)
Parallel 24: Hepatitis B: Virology and Immunology
Authors: Sven Francque, Pierre Bedossa, Joost Drenth, Sandra Phillips, Jason Coombes, Sameer Mistry, Roger Wil- Liams, Wing-Kin Syn, Shilpa Chokshi, Shun Kaneko, Sei Kakinuma, Yasuhiro Asahina, Akihide Kamiya, Sayuri Nitta, Tomoyuki Tsunoda, Masato Miy- Oshi, Hiroko Nagata, Fumio Goto, Satoshi Otani, Miyako Murakawa, Fukiko Kawai-Kitahata, Yasuhiro Itsui, Mina Nak- Agawa, Seishin Azuma, Mamoru Watanabe, Yasuhiro Asa- Hina, Masato Miyoshi, Mina Nakagawa, Upkar Gill, Laura Rivino, Nina Le Bert, Kamini Kunasega- Ran, Damien Tan, Sarene Koh, Machteld Van Den Berg, Yang Cheng, Navjyot Hansi, Graham Foster, Evan New- Ell, Antonio Bertoletti, Patrick Kennedy
Journal: Hepatology (2015)
Medical News
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Transfusion, Milwaukee
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Preventing Electrocutions During Work With Scaffolds Near Overhead Power Lines
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PLoS Medicine Issue Image | Vol. 1(1) October 2004
Journal: PLoS Medicine (2004)

I have been a print maker for over ten years. During that time, I have traveled from Korea to Japan, Canada, and America, and my memories of these other cultures and people are built into my art. Etching and woodcut are my main media for expression. Using etching, I can show delicate feelings and complicated images, especially of the body and nature. In this work, I show the harmony of humans and nature that I remember from childhood. Image Credit: Heejae Suh (heejaes@yahoo.com)
Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12
Authors: Burkhard Becher, Brigit G. Durell, Randolph J. Noelle
Journal: Journal of Clinical Investigation (2002)

IL-12 is considered a critical proinflammatory cytokine for autoimmune diseases such as multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE). IL-12 is a heterodimer composed of a p35 subunit and a common p40 subunit shared by other cytokines. Both IL-12 p40–/– and p35–/– mice fail to produce IL-12 p70 heterodimer. However, in contrast to p40–/– mice, p35–/– mice are highly susceptible to the induction of EAE, establishing that IL-12 p70 is not essential for the development of EAE. When compared with wild-type mice, both p40–/– and p35–/– mice show deficiencies in primary IFN-γ responses by lymph node cells. Expression profiling of the inflamed CNS revealed that Th2 cytokines such as IL-4 and IL-10 are upregulated in p35–/– mice, whereas LT-α and TNF-α levels are reduced. These studies show that a molecule other than IL-12 p70, which uses the p40 subunit, fulfills the functions previously attributed to IL-12 with regard to the development and pathogenesis of this autoimmune disease.
Transplantation of gut microbiota derived from MCJ-KO genotype determines a protective profile against non-alcoholic fatty liver disease in germ-free mice
Authors: Naroa Goikoetxea, David Porras, María-Victoria García-Mediavilla, Héctor Rodríguez, Esther Nistal, María Juárez, Susana Martinez Florez, Maider Bizkarguenaga, Mercedes Rincón, Javier González-Gállego, Marta Varela-Rey, Leticia Abecia, Juan Anguita, María Luz Martínez-Chantar, Sonia Sánchez-Campos
Journal: Journal of Hepatology (2020)
Final results from a phase II study of 5-fluorouracil, oxaliplatin, and dasatinib (FOLFOX-D) in previously untreated metastatic pancreatic adenocarcinoma.
Authors: Thomas J. George, Jason Scott Starr, Hiral D. Parekh, Alison Marguerite Ivey, Susan P. McGorray, Yu Wang, Long H. Dang, Karen Colleen Daily, Carmen Joseph Allegra, David L. DeRemer, Steven J. Hughes, Margaret A. McEwan, Isis Barnes, Jessica L Cioffi, Jose Gilberto Trevino
Journal: Journal of Clinical Oncology (2018)

4124 Background: Systemic chemotherapy for pancreatic adenocarcinoma (PCa) improves survival but most targeted agents have consistently failed to demonstrate clinical benefits. Src is overexpressed in PCa and promotes an aggressive cancer phenotype. Dasatinib (D) is an oral multi-tyrosine kinase inhibitor (TKI) affecting tumor proliferation through inhibition of Src, Bcr-Abl, CKit and other pathways. Inhibition of Src is associated with biologic modifications favorably modifying the PCa phenotype and has synergy with restoring inherent chemosensitivity. Src inhibition can also increase oxaliplatin activity and modulate Tcell responses. The addition of D to the well-established backbone of FOLFOX represents a multifaceted line of scientific investigation. Methods: This phase II trial is to determine activity and toxicity of FOLFOX + D in previously untreated metastatic PCa. Pts must have at least 1 RECIST measurable target lesion, ECOG PS 0-2, normal QTc and adequate organ function. Treatment is standard q14d cycles of mFOLFOX6 with continuous D (150mg PO daily). Tumor assessments occur q8w. Endpoints are PFS (primary), objective and biochemical response rates, clinical benefit rate, freedom from metastases, overall survival (OS), toxicity, and quality of life. Exploratory tissue, CTC and serum analyses to identify predictors of response are planned. Sample size is based on a 50% improved median PFS from 4 (historical) to 6 mo. Results: 42 of 44 enrolled pts are evaluable. Baseline demographics are in Table 1. Median PFS was 4.0 mo (95% CI 2.3-8.5; range 0.1-43.3) and OS was 10.6 mo (95% CI 6.9-12.7; range 0.1-47.9). RR was 24% with clinical benefit rate (CR + PR + SD) of 60%. 10 pts (24%) were on active therapy more than a year with a few long term exceptional responders. Toxicity has been previously reported. Molecular profiling of Src expression and circulating biomarkers is ongoing. Conclusion: Addition of D to FOLFOX failed to significantly improve PFS in an unselected cohort of PCa pts. Toxicity was manageable. Analysis of Src expression in exceptional responders is ongoing. Clinical trial information: NCT01652976.Baseline patient demographics. Variable Median value (%) Age 65 (range 29-81) Race Caucasian n = 37 (88) Gender Male n = 28 (67) Prior adjuvant therapy 7 (17); gemcitabine-based History of diabetes 11 (26) Current or Former smoker 20 (48) Serum CA19-9 3011 (range 1- > 10000) U/mL ECOG PS 0 (n = 22); 1 (n = 17); 2 (n = 3)
Mercury in fish
Authors: T. H. Jukes
Journal: JAMA (1975)

POLLUTION and contamination with mercury is an interesting and complex story, for in a toxicological sense there are "two mercurys." On the one hand, mercuric chloride and methylmercury are highly poisonous. Compounds of mercury, especially in fish and shellfish, have caused widely publicized incidents of poisoning in human beings. On the other hand, mercurous chloride was used as a laxative, and mercury and its compounds are employed in chemotherapy, in diuretics, and by dentists. All of the poisonings with mercury were tragic; some were caused by flagrant and inexcusable neglect by industry; others by illiteracy or even stupidity. The uproar over mercury in swordfish and canned tuna was unnecessary and somewhat ludicrous. The discovery of the protective effect of selenium was fascinating, and did much to clear the air. "All the rivers run into the sea, yet the sea is not full; unto the place from whence the rivers come,
Ochrobactrum anthropi Meningitis Associated With Cadaveric Pericardial Tissue Processed With a Contaminated Solution—Utah, 1994
Journal: JAMA (1996)

From October 22 through November 3, 1994, three cases of Ochrobactrum anthropi meningitis were diagnosed among pediatric patients at a hospital in Utah (hospital A). The three patients had undergone neurosurgical procedures in which pericardial grafts processed at hospital B were used to close defects of the dura mater. This report summarizes the case investigations, which document that the cases resulted from human pericardial tissue grafts contaminated with O. anthropi.
The Quality Oncology Practice Initiative Program: Experience in Spain.
Authors: Rafael Lopez, Antonio Anton, Enrique Aranda, Alfredo Carrato, Manuel Constenla, Juan Jesús Cruz, Eduardo Díaz-Rubio, Margarita Feyjoo, Jesús García Foncillas, Pedro Gascon, Vicente Guillem, Ilse Lugo, Carlos Camps
Journal: Journal of Clinical Oncology (2019)

e18267 Background: Patient care quality is a discipline with enormous relevance in today’s healthcare. Quality Oncology Practice Initiative (QOPI) is a referral worldwide in quality for oncology practices. The ECO Foundation is a collaboration of experts representing the major Spanish hospitals in the pursuit of excellence in cancer treatment. ECO reached an agreement with QOPI to involve Spanish hospitals in the QOPI program. Methods: 7 rounds of data collection have taken place (Fall 2015 to Round 2 2018). Practices had to register online and submit data into the QOPI platform, and the ECO Foundation offered them the necessary support. 18 Spanish hospitals have participated in the 7 rounds, and 12 of them have repeated participation. Core, Lung Cancer and Breast Cancer modules were completed. Results: During the 7 rounds, 2341 charts were submitted by the Spanish practices. The percentage of participating practices that presented results higher than 70% was successively 64%, 50%, 75%, 100% in the three following rounds and 88% in the last round. For the 12 hospitals that repeated participation, 8 reported improvements at different degrees of their global scores. These hospitals specifically show an improvement in the QOPI measures related to the signed patient consent for chemotherapy and the documentation of the patient consent in the practitioner note, the chemotherapy intent documentation, the appropriate completion of the chemotherapy planning, the documentation of the number of chemotherapy cycles and the development and documentation of the pain assessment. On the other hand, regarding QOPI Certification, three Spanish hospitals have received this accreditation in September 2017 and one in June 2018. Conclusions: These preliminary results are a good starting point for the continued implementation of the QOPI program in Spain, thus providing a well-structured approach to analyze cancer care. The ECO Foundation will continue pursuing excellence and quality with further activities like the QOPI Certification program and Quality Training Program, with these performed for the first time in Spain in 2017 and 2018 respectively.
Medical Education and State Boards of Registration
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 932: Temporal Changes In The Contribution Of Protein Kinase C Isoforms To Myogenic Constriction In Rat Posterior Cerebral Arteries
Authors: Toshihide Kashihara, Koichi Nakayama, Tomohisa Ishikawa
Journal: Circulation (2007)

Background Cerebral arteries respond to an increase in intraluminal pressure with vasoconstriction, being referred to as myogenic tone. A number of studies have postulated the mechanisms involved in the development of myogenic tone; however, less information is available about how myogenic tone is maintained. The present study thus investigated the mechanisms underlying sustained myogenic constriction in isolated rat posterior cerebral arteries. Methods and Results Long-term elevation of intraluminal pressure from 5 to 60 mmHg for 1 hr caused sustained constriction and [Ca 2+ ] i elevation. In the presence of rottlerin, a PKCδ inhibitor, the pressure-induced constriction and [Ca 2+ ] i elevation were gradually declined, and nearly abolished at the end of the 1-hr stimulation (sustained phase). In contrast, Gö 6976, a cPKC inhibitor, significantly inhibited the constriction for up to 5 min after the start of stimulation (initial phase), but had no effects on the [Ca 2+ ] i elevation. The pressure stimulation induced small [Ca 2+ ] i elevation even in the presence of nicaripine. Ruthenium red (RuR), a TRPV inhibitor, significantly inhibited the nicardipine-resistant [Ca 2+ ] i elevation in the initial phase. However, slowly developing [Ca 2+ ] i elevation was still observed in the sustained phase. In contrast, rottlerin had little effect on the initial phase, but significantly inhibited the sustained one. Moreover, the combination of RuR and rottlerin nearly abolished the nicardipine-resistant [Ca 2+ ] i elevation. PKCα, γ, δ, and ε, but not PKCβ, were detected by immunohistochemisty in smooth muscle cells of rat posterior cerebral arteries. Conclusions PKC isoforms have different roles in the development and maintain of the myogenic constriction in rat posterior cerebral arteries: cPKC (α and/or γ) mediates Ca 2+ sensitization in the initial phase, whereas PKCδ mediates [Ca 2+ ] i elevation via the activation of RuR-resistant cation channels in the sustained phase. Table. Effects of PKC inhibitors on pressure-induced constriction and [Ca 2+ ] i elevation
JAMA 75 YEARS AGO
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Deutsche Medizinische Wochenschrift, Stuttgart
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal