tbuckley/cabot-search huggingface dataset:
Structure-Activity Relationships of Estrogens
Authors: V. Craig Jordan, Shubhra Mittal, Barbara Gosden, Rick Koch, Mara E. Lieberman
Journal: Environmental Health Perspectives (1985)

The last 50 years has seen an exponential rise in the published reports about estrogen action. The model to describe the early events in the mechanism of action of estrogens via the estrogen receptor is updated in this paper to incorporate some of the recent data on the subcellular localization of the receptor. New evidence suggests that the receptor is a nuclear protein, so it appears that estrogens must first diffuse into the nuclear compartment to initiate estrogen action via the receptor complex. This review traces the development of potent estrogenic compounds by the study of their structure-activity relationships. Studies of structure-activity relationships in vivo using Allen Doisy or 3-day uterine weight tests can provide much valuable information, but the assays suffer from the complex problems of pharmacokinetics and metabolic transformation. Studies in vitro using primary cultures of rat pituitary or uterine cells to assay the ability of a compound to induce prolactin synthesis or progesterone receptor synthesis, respectively, can provide essential information about the structural requirements for a compound to produce estrogenic effects. Nevertheless, it should be pointed out that studies in vivo are required to determine whether a compound is metabolically activated to an estrogen. Estrogen receptor binding models are presented to describe the changes in a molecule that will predict high affinity for the ligand and agonist, partial agonist and antagonist properties of the ligand-receptor complex. Most estrogenic pesticides and phytoestrogens comform to the predictions of the estrogen receptor binding model.
Ankle Injury
Authors: Jack Edeiken
Journal: JAMA (1978)

ANKLE injury is one of the most frequent injuries examined by the primary care physician. In the absence of fracture, he must distinguish sprains from complete ligamentous tears. At times he must request stress roentgenograms of the ankle. Ankle injuries may be classified into three broad categories: (1) mild sprain, (2) moderate to severe injuries as indicated by moderate soft-tissue swelling and pain, and (3) severe injury with gross fracture and dislocation. Fortunately, most injuries are mild sprains, and no permanent damage ensues. Severe injuries are generally referred to an orthopedic surgeon for roentgenographic examination and subsequent management and, therefore, are not a problem to the primary care physician. However, the second group of moderate injuries is of most concern. Some moderate injuries are entirely ligamentous or include a small chip fracture, indicating instability of the ankle mortise. The seriousness of these injuries is often unrecognized and inadequately treated, and
My Mirror
Authors: Robert A. Green
Journal: Annals of Internal Medicine (1998)

Ad Libitum15 July 1998My MirrorRobert A. Green, MDRobert A. Green, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-129-2-199807150-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail I have watched you searchyour face in the mirroreach morning.Neck up, neck down, side turn, side turn.I know it is not vanitynot the wrinkles themselvesfor which you search.It is for the signs-the first signsthe first tracksthe first intimations of changeof age of death of dissolutionmortality.I smile. I know the announcement will not come for me this way,bit by bit.Not for me.Not a minuscule omenbut a bangan epiphanya sign of blood, a flash of pain, a lump of tissuea trumpet call.And then today.A periodic examination.With the radiologist, I look at the IVP, the ... Author, Article, and Disclosure InformationAffiliations: Previousarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 July 1998Volume 129, Issue 2Page: 159KeywordsBladderBloodComputed axial tomographyHerniaIntravenous pyelographyMortalityRadiologistsSpine ePublished: 15 August 2000 Issue Published: 15 July 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Massachusetts Medical Society
Authors: John F. Conlin
Journal: New England Journal of Medicine (1949)

COMMITTEE ON LEGISLATIONOne of the most controversial issues before the Massachusetts General Court during the current legislative session was the Cash Sickness Compensation Bill. This bill was strongly supported and strongly opposed. Hearings were stormed and stormy.The bill provided for a state-operated monopolistic compulsory cash sickness program for workers. Major argument hinged chiefly upon this proviso. A spokesman for the CIO stated before committee, "I think this is legislation that is long overdue. It happens to be in the Governor's message and I want to say very emphatically that if we don't get a state fund program, we . . .
Heritability of blood pressure.
Journal: BMJ (1978)

Heritability of blood pressure Ever since Morgagnil commented on the familial occurrence of apoplexy investigators have been trying to determine whether cardiovascular risk factors are inherited.Soon after measure- ment of the arterial blood pressure became a common proce- dure Stocks2 showed that there was a stronger correlation between the blood-pressure levels of monozygotic than of dizygotic twins.Kahler and Weber3 confirmed these observa- tions, finding that the difference in pressure between mono- zygotic twins was 6 3 mm Hg but between dizygotic twins 11 i4 mm Hg; while Feinleib et a14 found a correlation coefficient of 0 55 for male monozygotic twins but only 0-25 for dizygotic pairs.In all these studies it was difficult to separate the effect of common genes from that of shared environment.In theory, studies on the blood-pressure correlation between husbands and wives should answer this question, since they share their environment but not their genetic material.The results of such investigations have been less clear-cut than those of twin studies,5 but the correlation coefficient seems in general much lower for spouse pairs than for genetically related members of the same family.Adopted children also show a very low
Prolonged survival of E coli but not Staphylococcus aureus in monocytes from patients with Crohn's disease
Authors: T. R. Elliott, B. Hudspith, C. Karaiskos, N. Rayment, J. D. Sanderson
Journal: Gut (2011)

<h3>Introduction</h3> A primary macrophage defect has been proposed to play a role in Crohn9s disease (CD) pathogenesis.1 In CD, <i>Escherichia coli</i> persist within lamina propria macrophages and peripheral blood monocytes are unable to effectively kill <i>E coli</i> in vitro.23 It is uncertain whether this abnormal bacterial handling by monocytes and macrophages in CD is limited to certain strains of <i>E coli</i> or whether a broader bacterial killing defect exists. The aim of this study was to compare intracellular survival of <i>E coli</i> with <i>Staphylococcus aureus</i> (not a usual resident of gut flora) within CD-derived and control monocytes. <h3>Methods</h3> Peripheral blood was taken from eight healthy controls and nine CD patients. CD distribution was ileal (n=1) and ileocolonic (n=8). Three CD patients were on thiopurines. Monocyte isolation was performed by iodixanol barrier flotation. Monocytes were challenged with a CD-derived strain of <i>E coli</i> and <i>methicillin sensitive Staphylococcus aureus</i> (MSSA). After 1 h incubation, the gentamicin protection assay was performed. Monocytes were lysed to release internalized bacteria after further incubation for 1 and 4 h. Cell lysates were plated on agar and incubated for 24 h at 37°C. Colony forming units (CFU) were counted after both 1 and 4h incubation. The CFU counts at these time points allowed relative replication to be determined. <h3>Results</h3> Viable CD-derived <i>E coli</i> were cultured from cell lysates at 1 and 4 h from 9/9 CD patients, and in 3/8 HC9s (mean increase CFUs from 1 to 4 h: CD +394%, HC −7%). Viable <i>S aureus</i> was cultured in cell lysates at 1 and 4 h respectively from 1/9 and 0/9 CD patients and 0/8 healthy controls at both time points. The difference in the number of CFU9s present for each subject at 1 and 4 h was calculated and there was a statistically significant difference in mean rank of (CFU (4 h) – CFU (1 h)) between CD and HC9s for <i>E coli</i> but not for staph aureus (Mann–Whitney U test). <h3>Conclusion</h3> Within CD-derived peripheral monocytes, intracellular survival is prolonged for <i>E coli</i> but not for <i>S aureus</i>, illustrating that impairment of killing by monocytes in CD is restricted to particular bacteria. This is consistent with the clinical observation that CD primarily affects the gut which has an extensive but specific microbiome, rather than causing systemic immunodeficiency characterised by infections in other systems.
Incremental Value of Thallium-201 Imaging
Authors: Raghuveer K. Halkar
Journal: Annals of Internal Medicine (1995)

Letters1 June 1995Incremental Value of Thallium-201 ImagingRaghuveer K. Halkar and Yavuz A. TarcanRaghuveer K. HalkarSearch for more papers by this author and Yavuz A. TarcanSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-122-11-199506010-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Christian and colleagues [1] included in their paper a paragraph about limitations, citing the main limitation as referral bias. However, we wonder whether it is fair to assess the incremental value and cost-effectiveness of any test in a study in which the result of the test itself influenced the decision to proceed to the end point of the study. The structured abstract format (summary) uses subtitles such as objective, design, participants, measurements, setting, results, and conclusions; however, casual readers may not realize the study has serious limitations. We suggest including a limitations subtitle. This suggestion may also ...REFERENCE1. Christian TF, Miller TD, Bailey KR, Gibbons RJ. Exercise tomographic thallium-201 imaging in patients with severe coronary artery disease and normal electrocardiograms. Ann Intern Med. 1994; 121:825-32. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1995Volume 122, Issue 11Page: 881-883 ePublished: 15 August 2000 Issue Published: 1 June 1995 Copyright & PermissionsCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
New Volume of Hare's System of Practical Therapeutics.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Money Value of a Man.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dependence on cyanocobalamin injections
Authors: H. L. Newbold
Journal: JAMA (1989)

<h3>To the Editor. —</h3> The April 7<i>JAMA</i>article by Drs Lawhorne and Ringdahl<sup>1</sup>ignores vitamin B<sub>12</sub>dependency disorders and thus may leave readers with the false impression that only patients with low serum vitamin B<sub>12</sub>levels require the administration of cyanocobalamin. Patients suffering from vitamin B<sub>12</sub>dependency disorders do not thrive without extra amounts of the vitamin. The<i>Merck Manual</i><sup>2</sup>states: "Several specific disorders of cobalamin-dependent metabolism have been reported. In each there is some defect either in (1) cellular uptake of the vitamin precursor, (2) conversion of the vitamin to the coenzyme form, or (3) coenzymeapoenzyme interaction.... These disorders usually respond to massive doses of vitamin B-12 (1000 mcg/day IM)." Rosenberg<sup>3</sup>reported on vitamin B<sub>12</sub>dependency disorders, and I have published an article correlating psychological tests scores with serum vitamin B<sub>12</sub>levels in eight patients suffering from vitamin B<sub>12</sub>dependency
American Journal of Medical Sciences, Philadelphia
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lectures on the History of Medicine
Authors: A. Henry
Journal: BMJ (1860)

results are obtained.They are deduced from the whole of the figures employed, and not from a part of them only.It is not out of every forty-five persons living in England and Wales in one year that one death happens.We could not undertake to say that, out of forty-five persons occupying some large country mansion, or some school, or some small group of houses, throughout a year, one would die.We should prove very bad prophets if we did.Our assertion that one in forty-five of the living population dies annually applies to the whole population of England and Wales, of both sexes, and all ages, but not to every group of five and forty persons, and especially not to every group of forty-five infants or forty-five aged men or women.It must be obvious to the meanest capacity that this large truth, expressed in numbers, has no practical application whatever to any individual man, woman, or child; and that it could not even be safely applied to any single group of forty-five persons, though closely resembling, in the sexes and ares of the persons of whom it consists, the population of England and Wales of which it forms a part.
Multiple Asymptomatic Violaceous Macules on the Thigh—Diagnosis
Journal: JAMA Dermatology (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Oral contraceptives and thromboembolic disease
Authors: V. A. Drill
Journal: JAMA (1968)

The average normal incidence of thrombophlebitis in nonpregnant women of childbearing age is one case per 1,000 women per year based on data from hospital admissions, and 2.2 cases per 1,000 women per year based on data from visits to the physician. The antepartum incidence is 0.5 cases per 1,000 women per nine months. In studies with oral contraceptives, the average incidence was 0.5 cases per 1,000 women per year. Evidence does not indicate that the administration of oral contraceptives to women with a history of thrombophlebitis increases the chance of recurrence of the disease. Data in the United States do not demonstrate an increase in death rate from pulmonary embolism, and vital statistics for England do not show an increase in the ratio of women to men dying from thromboembolic diseases since the introduction of oral contraceptives.
A Lecture on Urinary Calculi
Authors: L. Beale
Journal: BMJ (1861)

pulsation in the tumour, and greater freedom of breathing.I did not see her from 1851 till 1856, when, being in London, she called to show herself, saying how well she was.The pulse in the radial had not returned; but there was no pulsation in the tumour, and only a sort of roughness in the sound of the artery.She felt confident herself of the good effect of the starving treatment.I have taken the opportunity of your having two patients together under your eye to bring this sub- ject before you, because of late the objections urged against venesection in excess and in improper cases have produced a fashion of decrying its use alto- gether, and especially in thoracic aneurism.Bleed- ing and starving, say they, induce debility and anvemia; that is to say, in physiological language, they lower the force of the heart, and they cause a comparative excess of fibrine over blood-discs in the blood.These are both steps towards the mode adopted by Nature to effect a cure in aneurism, and perhaps in some other diseases also.So that, I con- tend, not merely is it the best mode, but that it is the only honest mode, of treating aneurism of the trunk-vessels; because it is the only one we at present know consonant to reason and experience. Cavturc
Leads from the MMWR. Illness and death due to environmental heat--Georgia and St Louis, 1983
Journal: JAMA (1984)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Methandrostenolone and Nandrolone Decanoate in Muscular Dystrophy: A Controlled Trial
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal