tbuckley/cabot-search huggingface dataset:
Ophthalmological Memoranda
Journal: BMJ (1887)

ISIS,Z#j*iQYX4o I[t1wI tumours-of the.phari have bee-n observed by Porter and Syme, due to,eum of the intern'al carotid; and BarnesP has deqcribed a phAryngeaspulsating tumour which was arrested by applying psrwsure, to the external carotid artery.Cresswell Baber3 ha recently reported a cosetppulsating artery on the posterior wall of the pliaryax.It is probable that this condition is by no means rare, since it has been oboorved at the Throat Hospital at least twice during the last year.
From the Secretary of Health and Human Services
Authors: L. W. Sullivan
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PERICARDIECTOMY: 50 YEARS OF EXPERIENCE
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Use of CA9 gene single nucleotide polymorphisms to predict prognosis and treatment response of metastatic renal cell carcinoma
Authors: M. de Martino, T. Klatte, D. B. Seligson, J. LaRochelle, B. Shuch, R. R. Caliliw, Z. Li, F. F. Kabbinavar, A. J. Pantuck, A. S. Belldegrun
Journal: Journal of Clinical Oncology (2009)

5003 Background: Carbonic anhydrase 9 gene (CA9) is located in a prognostically relevant chromosomal area on chromosome 9p and is encoding for one of the most significant protein markers in metastatic renal cell carcinoma (MRCC), CAIX. In contrast to CAIX protein, however, no efforts have been made to date to study CA9 gene in metastatic RCC. Here, we test the hypotheses that single nucleotide polymorphisms (SNPs) and mutations of the CA9 gene are associated with CAIX expression, response to immunotherapy and survival. Methods: Genomic DNA was extracted from frozen tumor samples of 54 patients with clear cell MRCC. All exons of the CA9 gene were PCR-amplified and sequenced. The antibody M75 was used to evaluate CAIX protein expression immunohistochemically. Statistical associations of CA9 gene status and CAIX protein expression with response to IL-2 based immunotherapy and overall survival were assessed with chi-square tests, t-tests, Kaplan-Meier survival estimates and Cox proportional hazards regression models. Results: CA9 reference SNP (rs) 2071676 was found in 59%, rs12553173 in 15%, rs3829078 in 11% and rs1048638 in 33% of the patients. The deletion c.376del393 was observed in two patients. CAIX expression was high (&gt;85%) in 65% of the patients. None of the SNPs was significantly associated with CAIX expression. Patients with the C allele variant of rs12553173 had improved median survival (27.3 vs. 13.6 months, p = 0.0431) and a greater likelihood of response to IL-2 (57% vs. 22%, p = 0.081) Likewise, high CAIX expression was associated with longer median survival (25.5 vs. 8.5 months, p &lt; 0.0001) and a greater IL-2 response rate (37% vs. 8%, p = 0.070). In a multivariate Cox model, both C allele variant of CA9 SNP rs12553173 and CAIX expression were retained as independent prognostic factors. Conclusions: CA9 SNPs are frequently found in patients with MRCC. The C allele variant of rs12553173 is associated with improved overall survival and a greater likelihood of response to IL-2. CA9 rs12553173 and CAIX are both independent prognostic factors of overall survival and complementary in predicting prognosis of MRCC. No significant financial relationships to disclose.
Renal colic shows a circadian pattern
Journal: BMJ (2002)

Some caution is needed in interpreting Cochrane reviewsCochrane reviews contain methodological and other weaknesses, in particular the over-rating by the reviewers in their conclusions of the benefits of new interventions.Olsen and colleagues (p 829) assessed the quality of a sample of 53 reviews first published in the Cochrane Library in 1998 and found major problems in 15.The evidence did not fully support the conclusion in nine reviews, the conduct or reporting was unsatisfactory in 12, and stylistic problems (such as errors in spelling or grammar) occurred in 12.The authors say that although the Cochrane Library remains a key source of evidence on the effects of health interventions, the reviews should be interpreted cautiously.
Abstracts
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Adaptive Coping Mechanisms in Adult Acute Leukemia Patients in Remission
Authors: Judith B. Sanders
Journal: JAMA (1977)

The adult leukemia patient in a drug-induced remission possesses a unique set of emotional responses as he adjusts to an altered life-style and a life-threatening disease. Six patients, ranging in age from 24 to 62 years and being treated with monthly maintenance chemotherapy, were interviewed over a six-month period. The adaptive coping mechanisms most frequently identified were denial of being sick, identification with fellow patients to form a "hospital family," and anticipatory grief of one's own losses by participation in grieving another patient's death. The means of adjustment was to adapt to the "hospital family" and benefit from the therapeutic milieu established on the ward. The patient's total response to remission in acute leukemia can be influenced positively by appropriate intervention based on an assessment of his previous and present patterns of coping. (<i>JAMA</i>238:952-954, 1977)
Syphilis
Authors: G. Marshall Crawford
Journal: New England Journal of Medicine (1946)

TherapyThe use of penicillin in the treatment of syphilis has developed with an explosive force almost analogous to that of the atomic bomb. The literature on this particular phase of the treatment of syphilis is so voluminous as to warrant a completely separate category. Consequently, it will be discussed in a separate section of this progress report.Moore42 has given a most instructive discussion of the chemotherapy of syphilis from the time of the first knowledge of the disease. This covers a period of four hundred and fifty-one years, which is divided into three main periods according to the . . .
Canadian Journal of Biochemistry, Ottawa
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Gender-Related Behavior in Women Exposed Prenatally to Diethylstilbestrol
Authors: Retha R. Newbold
Journal: Environmental Health Perspectives (1993)

Accumulating evidence in experimental animals over the past three decades suggests that mammalian brain development and differentiation of the central nervous system are influenced by perinatal exposure to sex hormones. Hence, changes in human behavioral patterns may be associated with prenatal exposure to estrogenic substances such as diethylstilbestrol (DES). This paper reviews relevant studies from a series of laboratories and finds that no clear-cut differences can be demonstrated to date between unexposed and DES-exposed women in gender-related behavior, although the physical and psychological impact of the problems associated with exposure to DES are well documented. If both prenatal and postnatal influences such as social, economic, and environmental factors are taken into consideration, individual variation is more apparent than differences in gender-related behavior between unexposed and DES-exposed women. In summary, gender-related behavior is determined by a complex array of interacting factors, and prenatal influences are only one of many developmental events. More studies are needed using larger populations with carefully controlled selection criteria to suggest a direct role of prenatal DES exposure on subsequent gender-related behavior.
Response
Authors: LEO UZYCH
Journal: JNCI Journal of the National Cancer Institute (1992)

Journal Article Response Get access LEO UZYCH LEO UZYCH Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 84, Issue 6, 18 March 1992, Pages 450–451, https://doi.org/10.1093/jnci/84.6.450-a Published: 18 March 1992
Effect of Tumor Necrosis Factor on the Human Fibrinolytic System
Authors: Paula Silverman, George H. Goldsmith, Thomas R. Spitzer, Esther H. Rehmus, Nathan A. Berger
Journal: Journal of Clinical Oncology (1990)

At the request of the authors, the following is a correction of reference 4 cited in the report "Effect of Tumor Necrosis Factor on the Human Fibrinolytic System" by Silverman et al (J Clin Oncol 8:468–475, 1990): Reference 4. Helson L, Green S, Carswell EA, et al: Effect of tumor necrosis factor on cultured human melanoma cells. Science 258:731–732, 1975.
MEDICAL PROGRESS.
Journal: JAMA (1883)

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Shifting work, sleep cycles are on the way to becoming another public health issue
Authors: C. A. Raymond
Journal: JAMA (1988)

GETTING A LITTLE SHUT-EYE used to be no more than a personal concern. Now it's becoming a public health issue. One of four American workers is engaged in shift work, according to a 1977 study from the National Institute of Occupational Safety and Health. The effects of this phenomenon now are at issue among police officers and power plant workers alike, in industries as diverse as medicine and manufacturing. Experts in sleep research hope that concrete changes in work schedules will be made, enabling workers to function in good health. Their concerns were outlined in a recent report warning of threats to public safety if policymakers ignore the impact of shift work (<i>Sleep</i>1988;1:101-109). And a recently completed first-of-its-kind study indicates that such changes can benefit both workers and employers. Investigators acknowledge that it will be difficult to implement changes without a clear-cut mandate and considerable agreement between labor and
ITALY
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hygiene for Freshmen
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
2018 BCVS Honorees: BCVS Melvin L. Marcus Young Investigator Award
Authors: Melvin Bcvs, Markus Wallner, Steven Houser'
Journal: Circulation Research (2019)

to enhance his scientific training in an outstanding lab.His main interest lies in heart failure (HF), more specifically, HF with preserved ejection fraction (HFpEF).While in Dr Houser's lab, Markus performed a cardiopulmonary characterization of a large animal model that mimics critical features of HFpEF and used this model to test the effects of inhibiting histone deacetylase catalytic (HDAC) activity.The pan-HDAC inhibitor SAHA exerted robust anti-remodeling effects, reduced left ventricular filling pressures, and improved myofibril relaxation and pulmonary function.Furthermore, HDAC inhibition affected the plasma metabolome and skeletal muscle fiber composition, both known to be impaired in human HFpEF.Markus's long-term goal is to be a translational scientist who develops therapies for patients with cardiovascular diseases in which the standard of care is inadequate.In June 2018, Markus moved back to Austria where he is currently finishing his residency at the Medical University of Graz, Division of Cardiology, chaired by Prof Andreas Zirlik.Markus looks forward to combining his interest in translational research and his commitment to treating patients.Furthermore, he is an active member of the European Society of Cardiology, serving as a current board member for Heart Failure Specialists of Tomorrow and Cardiologists of Tomorrow.He believes that stepping out of your comfort zone and getting comfortable with being uncomfortable is essential for evolving.Besides his passion for research and medicine, sports have had a central role throughout his life.Markus played for the Austrian youth national soccer team and still tries to stay as active as possible, but the most important thing in his life is family, especially his two little boys.
Reply
Authors: A. Fawcett
Journal: Gut (1996)

Letters to the editor, Book reviews cularis, and serosa receive their blood supply by secondary branches from the submucosal plexus of vessels.' 8 Vasa recta have clearly been demonstrated passing through the bowel wall and joining the submucosal plexus.' 6 Hence it seems probable that reduced serosal perfusion stems from either extramural vascular disease or obliterative lesions within the submocosal plexus.The colonic microcirculation represents the final common pathway for the delivery of oxygen and nutrients to the tissues of the bowel wall and we agree with Fawcett et al that its integrity is critical to successful anasto- motic healing.However, the importance of the serosal plexus, as emphasised by these authors remains open to question.It is note- worthy that the distal two thirds of the rectum is devoid of serosa and hence it is untenable that the vascularity of this layer plays any part in the healing of anastomoses below the peri- toneal reflection.Based on our own microradiographic and fluorescent x ray analysis studies,' 12-14 the submucosal region provides the cornerstone of perfusion of other layers of the bowel well.We believe that preservation of the submucosal plexus by careful extramucosal appositional anastomosis provides the most favourable set of circumstances for uneventful anastomotic healing.
Therapeutics.
Journal: JAMA (1900)

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