tbuckley/cabot-search huggingface dataset:
Saint Thomas' Hospital Reports.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prontuario di Posologia Dei Rimedi Più Usati Nella Terapie Infantile.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Regulation of Mammary Differentiation by the Extracellular Matrix
Authors: Joanne L. Blum, Mary E. Zeigler, Max S. Wicha
Journal: Environmental Health Perspectives (1989)

In multicellular organisms cell growth and differentiation are influenced by soluble factors, cell-cell interactions and cell-extracellular matrix interactions. We have used the rat mammary gland as a model system to study the role of extracellular matrix components in the regulation of milk protein gene expression. Since mammary epithelial cells differentiate on a basement membrane in vivo, we investigated the effects of basement membrane components on the expression of the milk protein genes, alpha-casein, alpha-lactalbumin, and transferrin. We have demonstrated that a basement membrane gel, as well as its major basement membrane component, laminin, induced alpha-casein and alpha-lactalbumin expression as much as 160-fold compared to tissue culture plastic. We demonstrate that laminin affects mRNA stability as well as having an effect on protein stability and secretion. Laminin interacts with mammary epithelial cells via an 68 kD cell surface receptor which is capable of interacting with the cellular cytoskeleton. In order to provide evidence that laminin affects on mammary differentiation are mediated through this receptor via the cytoskeleton, we examined the effects of cytoskeletal disrupting agents on milk protein gene expression. We demonstrate that cytochalasin D or colchicine selectively block laminin-mediated milk protein gene expression by affecting mRNA stability. Based on these experiments, we propose a model in which laminin affects mammary gene expression through interaction with cell surface receptors which interact with the cytoskeleton resulting in stabilization of mRNAs for milk protein genes.
Nathan Smith Davis(1817-1904), founder, teacher, editor
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
References and Reviews
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nonalcoholic Steatohepatitis
Authors: Basil E. Akpunonu
Journal: Annals of Internal Medicine (1997)

Letters1 September 1997Nonalcoholic SteatohepatitisBasil E. Akpunonu, MD, MSc and Douglas J. Federman, MDBasil E. Akpunonu, MD, MScMedical College of Ohio; Toledo, OH 43699Search for more papers by this author and Douglas J. Federman, MDMedical College of Ohio; Toledo, OH 43699Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-127-5-199709010-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In their review of NASH, Sheth and colleagues [1] reaffirmed the proposed diagnostic criteria for this condition; liver biopsy specimens showing moderate to gross macrovesicular fatty infiltration with inflammatory processes in the absence of serologic evidence of known viral hepatitides and substantial alcohol consumption.Conditions almost always associated with NASH include obesity, diabetes mellitus, and hyperlipidemia (hypercholesterolemia, hypertriglyceridemia, or both). However, the temporal relation between NASH and diabetes mellitus has not been described previously. While evaluating patients with chronically elevated liver function test results, we noted that the diagnosis of NASH preceded the diagnosis of diabetes mellitus ...References1. Sheth SG, Gordon FD, Chopra S. Nonalcoholic steatohepatitis. Ann Intern Med. 1997; 126:137-45. Google Scholar2. Wanless IR, Lentz JS. Fatty liver hepatitis (steatohepatitis) and obesity: an autopsy study with analysis of risk factors. Hepatology. 1990; 12:1106-10. Google Scholar3. McGarry JD, Foster DW. Regulation of hepatic fatty acid oxidation and ketone body production. Ann Rev Biochem. 1980; 49:395-420. Google Scholar Author, Article, and Disclosure InformationAuthors: Basil E. Akpunonu, MD, MSc; Douglas J. Federman, MDAffiliations: Medical College of Ohio; Toledo, OH 43699 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byA case–control study of non-alcoholic fatty liver disease in breast cancer 1 September 1997Volume 127, Issue 5Page: 410KeywordsBiopsyDiabetes mellitusHepatitisHyperlipidemiaInsulinLiverNonalcoholic steatohepatitisObesityThyroidType 2 diabetes ePublished: 15 August 2000 Issue Published: 1 September 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Elective Intra-aortic Balloon Pump Placement in High-Risk Percutaneous Coronary Intervention
Authors: Annemarie E. Engström, Krischan D. Sjauw, José P. S. Henriques
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Moving In Three-Dimensional Space: Frames Of Reference, Vectors, And Coordinate Systems
Authors: J. Soechting
Journal: Annual Review of Neuroscience (1992)

The brain's default mode network consists of discrete, bilateral and symmetrical cortical areas, in the medial and lateral parietal, medial prefrontal, and medial and lateral temporal cortices of the human, nonhuman primate, cat, and rodent brains. Its ...Read More
Pelvic Haematocele
Authors: F. Imlach
Journal: BMJ (1886)

was recommended by my first patient, Dr. M., to come to nie, as he was suffering from traumatic deafness of the right ear, and the left was useless through complete occlusion of its meatus by a large ivory exostosis.In the earlier of two operations for the removal of the tumour, the steel guard broke in the ear, and could only with difficulty be extracted.An iron guard, which I had by me, was then substituted.It is important, I may here note, to have the guard made of metal that will bend with- out snapping when subjected to strain.The treatment, after the drilling of the exostosis in this case, resolved itself into the removal of granulations from the opening made, and the patient then recovered his hearing.CASE IV. -In my next case, that of Miss M., aged 19, sent to me by Dr. McMunn in September, 1881, there were two osseous growths in the right ear, which caused complete deafness as regarded air-con- ducted sounds.Both were pedunculate, and one was attached to the posterior, the other to the anterior, wall of the mettus.They were removed by means of a denti4t's stump-forceps, not being of an ivory- like consistency.Cases similar to this are not unfrequent in hospital- practice, in which the ivory-like growths are of comparatively rare occurrence.CASE v.-Miss A. was first seen by me on February 17th, 1882.She had, in consequence of measles at the age of 6, for twelve years been the subject of a constant purulent discharge through the right membrana tympani; and, since Christmas, 1881, she had been increasingly deaf.I discovered an ivory exostosis attached to the posterior wall of the meatus, but, as this had not attained size sufficient to impede free escape of the discharge, I deferred treatment for a while.In the following May, when I next saw my patient, the exostosis had so increased in size that only a slender probe could be passed between it and the anterior wall of the meatus, the flow of the discharge was hindered, and deafness was complete.Removal of the obstruction was now evidently requisite, as retention of pus in the meatus might have been attended with serious risk to the patient's life.The com- plete drilling of the growth was effected in about half an hour ; and, very soon after the operation, the patient's hearing began to return, and, after the lapse of a couple of months, it was fairly restored, not- withstanding the existence of a perforation in the membranatympani.In this case, the origin of the exostosis was evidently inflammation set up by a perpetual discharge from the middle ear.CASE vi.-J.F., a girl, aged 18, came to me as a hospital patient,
Desmopressin: A Nontransfusional Hemostatic Agent
Authors: P. Mannucci
Journal: Annual Review of Medicine (1990)

CD40 is a cell-surface member of the TNF (tumor necrosis factor) receptor superfamily. Upon activation, CD40 can license dendritic cells to promote antitumor T cell activation and re-educate macrophages to destroy tumor stroma. Numerous agonist CD40 ...Read More
Using tools of epidemiology, physicians monitor medical care
Authors: D. E. Riesenberg
Journal: JAMA (1986)

For more than a decade, small-area analysis has been quietly progressing, mostly in New England. Not coincidentally, that is where John Wennberg, MD, and Phillip Caper, MD, work. Small-area analysis refers to the process of examining variations in medical care among hospital market areas, usually within the same state or region. "These studies extend classic epidemiologic approaches to the study of health services, allowing us to find differences in ways those services are being received," says Caper, professor of public policy at Dartmouth Medical School, Hanover, NH. In the 1970s, Wennberg, now professor of epidemiology at Dartmouth Medical School, discovered considerable differences in the rate of hysterectomies performed (per 10,000 residents) among various "small areas" in Maine. The method of analysis controlled for age, sex, and "border crossing" in the populations studied (<i>The Journal of the Maine Medical Association</i>1975;66:123-149). He had soon found similar variations in the rates of
Sleep Apnea
Journal: JAMA (1981)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Transplantation, Baltimore
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Physician-oriented data processing
Authors: S. Raymond
Journal: JAMA (1975)

PATIENT care as a primary objective of the laboratory computer has often been overlooked by people who design laboratory systems. The clinical pathologists, microbiologists, chemists, hospital administrators, laboratory equipment manufacturers, and especially the computer designers have frequently tried to decide what the laboratory itself needs, and what kind of services it will provide, rather than asking what the physician needs and wants from the laboratory for the care of his patients. There has been a fairly high degree of agreement within the computer industry as to what the clinical laboratory needs and wants, although in practice their systems have not achieved widespread success (fewer than 3% of clinical laboratories have computer systems<sup>1</sup>). Computer industry proposals usually call for a high degree of automation and for complete computerization of the clinical laboratory. The systems proposed are usually based on large central computers to be used for all hospital data processing
Highlights
Journal: JAMA Surgery (2015)

Although previous studies have analyzed risk factors for hospital readmission following major surgery, the eff ect of weekend discharge has not been investigated.Cloyd et al used the California Offi ce of State Health Planning and Development database to show that patients discharged on a weekend following abdominal aortic aneurysm repair, colectomy, pancreatectomy, or hip replacement surgery were not at an increased risk for hospital readmission.
Ear wax:
Authors: Tony Wright
Journal: BMJ (2015)

<h3>Abstract</h3> <h3>Background</h3> Previous kinship models analyze female kin through female lines of descent, neglecting male kin and male lines of descent. Because males and females differ in mortality and fertility, including both sexes in kinship models is an important unsolved problem. <h3>Objectives</h3> The objectives are to develop a kinship model including female and male kin through all lines of descent, to explore approximations when full sex-specific rates are unavailable, and to apply the model to several populations as an example. <h3>Methods</h3> The kin of a focal individual form an age×sex-classified population and are projected as Focal ages using matrix methods, providing expected age-sex structures for every type of kin at every age of Focal. Initial conditions are based on the distribution of ages at maternity and paternity. <h3>Results</h3> The equations for two-sex kinship dynamics are presented. As an example, the model is applied to populations with large (Senegal), medium (Haiti), and small (France) differences between female and male fertility. Results include numbers and sex ratios of kin as Focal ages. An approximation treating female and male rates as identical provides some insight into kin numbers, even when male and female rates are very different. <h3>Contribution</h3> Many demographic and sociological parameters (e.g., aspects of health, bereavement, labor force participation) differ markedly between the sexes. This model permits analysis of such parameters in the context of kinship networks. The matrix formulation makes it possible to extend the two-sex analysis to include kin loss, multistate kin demography, and time varying rates.
Health hazard evaluation program
Authors: T. W. Thoburn
Journal: JAMA (1981)

<h3>To the Editor.—</h3> In the article "Areawide Chemical Contamination: Lessons From Case Histories" by Robert W. Miller, MD (1981;245:1548), the overall theme is that the alert clinician evaluating the alert patient is often the key to recognition and correct diagnosis of diseases caused by environmental hazards. One source of help for the physician in evaluating such hazards, if they involve the workplace, is the Health Hazard Evaluation Program of the National Institute for Occupational Safety and Health (NIOSH), an institute in the Centers for Disease Control (CDC). A physician who suspects that he may have encountered disease caused by occupational exposure may obtain advice, consultation, or a full-fledged field investigation of the problem by contacting the Hazard Evaluation and Technical Assistance Branch at 4676 Columbia Pkwy, Cincinnati, OH 45226, telephone (513) 684-2176; program director, James Melius, MD. Assistance can also be obtained from any of the ten regional offices (Table).
AAV-Directed Persistent Expression of a Gene Encoding Anti-Nicotine Antibody for Smoking Cessation
Authors: Martin J. Hicks, Jonathan B. Rosenberg, Bishnu P. De, Odelya E. Pagovich, Colin N. Young, Jian-ping Qiu, Stephen M. Kaminsky, Neil R. Hackett, Stefan Worgall, Kim D. Janda, Robin L. Davisson, Ronald G. Crystal
Journal: Science Translational Medicine (2012)

Gene therapy with an anti-nicotine monoclonal antibody limits nicotine access to the brain in mice and may be a potential therapy for cigarette addiction.
WASHINGTON NEWS
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal