tbuckley/cabot-search huggingface dataset:
Drug Legalization, Harm Reduction, and Drug Policy
Authors: Harry J. Kanin
Journal: Annals of Internal Medicine (1996)

Letters15 April 1996Drug Legalization, Harm Reduction, and Drug PolicyHarry J. Kanin, MDHarry J. Kanin, MDMilwaukee, WI 53233Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-124-8-199604150-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The article and editorial on the perception and regulation of drug use in the United States [1, 2] were illuminating but not convincing. One factor about legalization of drugs was not discussed; that is, nationalization of drugs and free distribution to all addicts, an approach that would eliminate the profit from drug use. The advantage of this approach would be twofold. First, the addict would not need to commit a crime to obtain money to buy drugs. The drug to which he or she is addicted would be given free. Second, because no profit would be associated ...References1. DuPont RL, Voth EA. Drug legalization, harm reduction, and drug policy. Ann Intern Med. 1995; 123:461-5. Google Scholar2. Musto DF. Perception and regulation of drug use: the rise and fall of the tide [Editorial]. Ann Intern Med. 1995; 123:468-9. Google Scholar Author, Article, and Disclosure InformationAffiliations: Milwaukee, WI 53233 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 April 1996Volume 124, Issue 8Page: 776KeywordsAddictsCrimeDrug administrationDrug distributionDrug policyDrug regulationDrugsHeroinMotivationPerception Issue Published: 15 April 1996 CopyrightCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Statement on Hypertension in Diabetes
Journal: Diabetes Care (1987)

Hypertension and diabetes mellitus are commonly associated. Hypertension contributes substantially to morbidity and mortality in the diabetic population. This report was prepared as a practical guide for the management of hypertension in diabetic patients. Although treatment of hypertension in most diabetic patients does not differ from that in nondiabetic patients, this report outlines some special considerations relevant to the presence of both diseases. For both hypertension and diabetes, basic nonpharmacologic therapy consists of dietary alterations, exercise, weight management, smoking cessation, and restricted alcohol intake. These measures should be instituted as initial therapy or concomitant with pharmacologic measures. The stepped-care approach to drug treatment in essential hypertension serves as a guide to therapy. Flexibility in the use of antihypertensive drugs is suggested, and selected practical issues in drug treatment are reviewed.
Health Effects in a Casual Sample of Immigrants to Israel from Areas Contaminated by the Chernobyl Explosion
Authors: Ella A. Kordysh, John R. Goldsmith, Michael R. Quastel, Svetlana Poljak, Ludmilla Merkin, Rachel Cohen, Rafael Gorodischer
Journal: Environmental Health Perspectives (1995)

We analyzed questionnaire and physician examination data for 1560 new immigrants from the former USSR divided into three groups by potential exposure to Chernobyl radiation. Two groups were chosen according to soil contamination by cesium-137 at former residences, as confirmed by our findings in a 137Cs body burden study. The third group consisted of "liquidators," persons who worked at the Chernobyl site after the disaster. Liquidators had greater self-reported incidences of symptoms commonly accepted as acute effects of radiation exposure, increases in prevalence of hypertension, and more health complaints. Excesses of bronchial asthma and health complaints were reported in children from the more exposed communities. Asthma prevalence in children potentially exposed in utero appears to be increased eightfold. Older adults from more exposed areas had more hypertension as assessed by history and measurements. These findings suggest the possible association of radiation exposure with several nonmalignant effects.
Neuropathology of Hereditary Dystopic Lipidosis
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MEDICAL HISTORY.
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Volunteer?
Authors: J. Garrott Allen
Journal: JAMA (1976)

<h3>To the Editor.—</h3> In the article by Holley et al (234:1051, 1975), the authors obfuscate the meaning of the terms "volunteer" and "paid" blood donors as they use them at their Fitzsimmons operation.<i>Both</i>groups are actually paid donors. Contrary to the ordinary connotation in civilian blood banking, their "volunteer" group consists of transient army personnel on active duty who are given three-day passes for the donations, a salary equivalent of $30. The hepatitis surface antigenpositive reaction rate of this group was nine times greater than for the second group, just as is that of the paid transient donor population in civilian life. The second group, labeled "paid," consists of stable active and retired military personnel on steady incomes. Their group resembles the civilian volunteer population, except that those at Fitzsimmons were paid $10 in cash. Why was this group paid at all? Was it as an honorarium, or was
Detection of Notifiable Diseases Through Surveillance for Imported Plague— New York, September-October 1994
Journal: JAMA (1995)

Recent reports of bubonic and pneumonic plague outbreaks in India (1,2) prompted the New York City Department of Health (NYCDOH) and the New York State Department of Health (NYSDOH), in conjunction with CDC, to develop an emergency response plan to detect and manage suspected cases imported by international air travel. This report describes the surveillance system implemented by CDC on September 27 and supplemental efforts by NYC/NYSDOH to guide and inform physicians about the outbreak, and summarizes clinical findings for 11 travelers who had symptoms suggestive of plague.
Correction
Journal: BMJ (1955)

Antibiotics for Holiday in Hot Climate Q.-I am about to undertake a motor tour in Yugoslavia, and should like to take a supply of antibiotics which would deal with as wide a variety of infections as possible.I believe the heat in summer is so great that it would be necessary to take a very stable compound in the absence of refrigeration facilities.What would you recommend?A.-Antibiotics in the dry solid form are not materially affected by short periods in a hot climate: the stability factor need therefore not affect the choice made.The commonest ailment during a holiday abroad is diarrhoea, and for treating this, if it is severe enough to suggest a dysenteric or other such infection, it is usual to take one of the less soluble sulphonamides, such as sulphaguanidine.Possible indications for antibiotics are septic infection of skin or wounds, acute sore throat, and pneumonia.Most of the bacteria likely to be responsible for any of these conditions are sensitive to the tetracyclines, and whichever of these is preferred would be a useful all-purpose drug in these circumstances.
The Cover
Authors: Elizabeth Pease
Journal: JAMA (1981)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
American Cancer Society National Conference—Gastrointestinal Cancer—1981
Journal: JNCI Journal of the National Cancer Institute (1981)

American Cancer Society National Conference—Gastrointestinal Cancer—1981 Get access JNCI: Journal of the National Cancer Institute, Volume 67, Issue 3, September 1981, Page 742, https://doi.org/10.1093/jnci/67.3.742-b Published: 01 September 1981
PRIMAQUINE FOR VIVAX MALARIA
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Benjamin Rush on politics and human nature
Authors: E. T. Carlson
Journal: JAMA (1976)

Of the dedicated band of 57 men who put their signatures to the Declaration of Independence on July 4, 1776, five were physicians—Josiah Bartlett and Matthew Thornton of New Hampshire, Lyman Hall and Oliver Wolcott of Connecticut, and Benjamin Rush of Pennsylvania. Rush, in particular, would soon exert a great influence on the new nation, both in medicine and politics, and he took special pride in participating in the independence effort<i>as a physician</i>, for he believed physicians were naturally inclined to patriotism, and that they had a great opportunity to exercise it.<sup>1</sup> Rush had begun agitating for political reform two years earlier. Angered like so many others by the June 1773 Act of Parliament that placed an import tax on tea, he published a series of articles in a Philadelphia newspaper under the pseudonym "Hamden," after John Hampden, hero of the Cromwellian rebellion, who had died fighting for
Recent progress in understanding the hormonal regulation of phosphodiesterases
Authors: M. Conti
Journal: Endocrine Reviews (1995)

LAYER after layer of novel regulatory circuits have been added to the map charting the signal transduction pathways that transport information throughout the cell. New components of these pathways are found at a breathtaking pace, and new functions for old components are continuously uncovered. It is now recognized that the complexity of these pathways resembles the intricacy and integration of the pathways of intermediate metabolism. This is especially true for the cyclic nucleotide-dependent signal transduction and its components, including cyclic nucleotide phosphodiesterases (PDEs).These are the enzymes that with cyclases control the intracellular concentration of cyclic nucleotides. With the development of new molecular tools, a wealth of new information has accumulated on the structure and function of these enzymes. Four years ago we reviewed the current knowledge on the mechanisms of hormonal regulation of PDEs (1). Here, we update this survey, reporting the most recent developments of this field. Since our previous review, many primary structures of the human and mammalian PDEs have been elucidated. This has brought about a better understanding of the structure/function relationship of these proteins. Furthermore, PDE gene structure is being actively investigated, adding a further dimension to the regulation of these enzymes and opening new avenues of investigation. Novel mechanisms of regulation have been uncovered, linking these enzymes to new hormone-dependent functions. As we will discuss in detail, the overall picture derived from these findings reinforces the concept that PDEs may serve three major functions in the cell target for hormones and neurotransmitters: 1) They are effectors in signal transduction, 2) they play a role in integrating different signal transduction pathways, and 3) they may also serve as a dampening device to decrease or terminate hormonal stimulation.
Painful mass in the thigh
Authors: G. F. Zinninger
Journal: JAMA (1966)

Dr. Thomas E. Shea: An 18-year-old girl was admitted because of pain in her thigh. She had been well until six months previously when she noted localized tenderness in the posterior aspect of her thigh. Two months before admission, she noted pain in the same area, which became more severe and persistent. Two weeks prior to admission she noted a mass in the thigh. Physical examination revealed a 15-cm soft-tissue mass in the posterolateral aspect of the thigh, which was tender but not fluctuant. <h3>Discussion</h3> Dr. Laurence L. Robbins: Dr. Hanelin, would you comment on this? Dr. Joseph Hanelin: There is a large soft-tissue mass and possibly some edema in the soft tissues (Fig 1), which indicates the presence of a deeply situated neoplasm or, less likely, an inflammatory process. There is no calcification within the tumor. There is a localized irregularity and destruction of a short segment of the
Reviewing new, very complicated drugs
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A serum pattern predictive of breast cancer
Authors: B. Mansfield, C. D. Shriver, P. Yip, B. Hitt, J. Hooke, S. Somiari, J. Flynn, M. Liebman
Journal: Journal of Clinical Oncology (2005)

9545 Background: Serum profiling may detect malignant disease. Low volume, high resolution mass spectrometry is capable of generating high complexity spectral profiles of the serum. Combined with powerful data-mining algorithms, coordinated changes in multiple serum species can be correlated with malignancy. Methods: 691 serum samples were analyzed: 32 women with no breast disease; 659 women with breast abnormalities (clinical or radiologic) made up of 204 benign non-neoplastic conditions; 111 benign neoplastic conditions; 24 atypical ductal hyperplasia only; 234 invasive cancer; 86 in situ CA, (61 DCIS and 25 LCIS). All sera were collected prior to biopsy, and processed promptly by a standard protocol. Individual diagnosis was based on pathology of tissue biopsy. Sera were analyzed on an ABI QSTAR time-of-flight mass spectrometer equipped with an Advion Nanomate System. Spectra obtained were used to build models using the Correlogic Systems Inc. ProteomeQuest software which combines lead cluster mapping with a genetic algorithm to identify patterns predictive of disease status. We held an independent set of spectra files out from model development as a blinded validation set to emulate a clinical setting. Results: A number of models were created which demonstrated sensitivities and specificities in the range of 80 - 90% on the blinded validation set. We identified three regions in the spectra that together contain at least 8 m/z features, which are very powerful in discriminating between invasive cancer and non-malignant conditions. Singly, the features are not very informative, but combined in a multi-dimensional model to reflect coordinated changes in the serum, the features are highly predictive of disease. One model, combining 10 features yielded 98.5% specificity (95% CI 95.2 - 99.6%) and 90.3% sensitivity (95% CI 82.4 - 95%) on a testing set of 196 non-malignant sera and 103 invasive sera, which dropped to 92% specificity (95% CI 74.5 - 93.6%) and 86% sensitivity (95% CI 76.4 - 97.8%) on a truly blinded validation set of 54 non-malignant and 41 invasive sera. Conclusions: Serum profiling using this technology and algorithm is reasonably accurate in classifying women with breast abnormalities prior to undergoing biopsy. Results support a larger study of these models. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Correlogic Systems
TOPICS OF THE WEEK.
Journal: JAMA (1890)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A randomized phase II study of individualized stereotactic body radiation therapy (SBRT) versus transarterial chemoembolization (TACE) with DEBDOX beads as a bridge to transplant in hepatocellular carcinoma (HCC).
Authors: Francis W. Nugent, Amir Qamar, Keith E. Stuart, Kari Galuski, Sebastian Flacke, Chris Molgaard, Frederick Gordon, Shams Iqbal, Klaudia Urbaniak Hunter, Erin Hartnett, Krishna Gunturu
Journal: Journal of Clinical Oncology (2017)

223 Background: For HCC pts undergoing LT, local regional treatment as a "bridge" is standard to decrease tumor progression. The most common treatment is TACE, but the best bridging modality is unclear. Recently, SBRT has been shown to be both safe and effective when used in pts with locally advanced HCC. We prospectively compare SBRT to TACE as a bridge for HCC pts undergoing LT. Methods: 60 pts planned for accrual. From 9/2014-9/2016, 29 pts within Milan Criteria with C-P Class A/B cirrhosis were randomized to TACE vs. SBRT. TACE pts received 2 treatments one month apart utilizing DEBDOX beads (n = 15). TACE pts were hospitalized after each TACE. Pts receiving SBRT (n = 12) received a median total dose of 45Gy delivered over 5 fractions using fiducials. Mean liver dose, Veff, and NTCP were utilized to determine the prescription dose. Pts were assessed by imaging using mRECIST criteria at 2 months and every 3 months thereafter until LT or death. Toxicity and quality of life were assessed before treatment, during treatment, two weeks post-treatment, and then every three months using the PIQ-6 Pain Impact Questionnaire and the SF-36v2 Health Survey. Primary endpoint was time to retreatment of treated lesion(s). Secondary endpoints include toxicity, pathologic response, radiologic response, number of subsequent treatments, cost, and QOL. Results: A. Demographics/Toxicity. Conclusions: For HCC patients with C-P Class A/B liver cirrhosis, SBRT appears equally effective to TACE as a bridge to liver transplantation, may engender less toxicity, and eliminates hospitalizations. Clinical trial information: NCT02182687. [Table: see text][Table: see text]