tbuckley/cabot-search huggingface dataset:
The authors reply
Authors: R. Furlan, M. Pagani, A. Malliani
Journal: Cardiovascular Research (1994)

Journal Article The authors reply Get access Raffaello Furlan, Raffaello Furlan Medicina Interna 11, Universith, Ospedale "L Sacco", 20157 Milano, Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar Massimo Pagani, Massimo Pagani Medicina Interna 11, Universith, Ospedale "L Sacco", 20157 Milano, Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar Alberto Malliani Alberto Malliani Medicina Interna 11, Universith, Ospedale "L Sacco", 20157 Milano, Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 28, Issue 1, January 1994, Pages 142–143, https://doi.org/10.1093/cvr/28.1.142 Published: 01 January 1994
NCCN NewsNCCN Imaging Appropriate Use Criteria Published for 15 Additional GuidelinesNCCN Challenges Medical Community to “Just Bag It” to Eradicate Deadly Medical ErrorNew NCCN Patient Education Materials Help Patients Combat Nausea and Vomiting; New Patient App Now AvailableNCCN Chemotherapy Order Templates to be Integrated into Cerner's Electronic Health Record
Journal: Journal of the National Comprehensive Cancer Network (2016)

Uterine Cancer • Vulvar Cancer NCCN Imaging AUC are an easy-to-use, single source for AUC pertaining to cancer screening, diagnosis, staging, treatment response assessment, follow-up, and surveillance as outlined within the library of NCCN Guidelines.NCCN Imaging AUC include all imaging procedures recommended in the NCCN Guidelines, including radiographs, CT scans, MRI, functional nuclear medicine imaging (PET, SPECT), and ultrasound.NCCN Imaging AUC are available through a Web-based user interface that provides a searchable and user-customized display of approved NCCN Imaging AUC.The complete library of NCCN Imaging AUC is scheduled to be available in 2017.The NCCN Guidelines are the recognized standard for clinical policy in cancer care and are often the most thorough and most frequently updated clinical practice guidelines available in any area of medicine.Other NCCN Guidelines derivative products include:• The NCCN Drugs & Biologics Compendium (NCCN Compendium), which contains authoritative, scientifically derived information designed to support decision-making about the appropriate use of drugs and biologics in patients with cancer.The NCCN Compendium is recognized by public and private insurers alike, including CMS and UnitedHealthcare, as an authoritative reference for oncology coverage policy.• The NCCN Biomarkers Compendium, which contains information designed to support decision-making around the use of biomarker testing in patients with cancer.• The NCCN Chemotherapy Order Templates (NCCN Templates), which include chemotherapy, immunotherapy, supportive care agents, doses, schedules, monitoring parameters, and safety instructions for regimens recommended in the NCCN Guidelines.Special instructions for self administered chemotherapeutic agents are also provided.
Presenile dementia.
Authors: C D Marsden, M J Harrison
Journal: BMJ (1972)

<h3>Abstract</h3> Pediatric brain tumors are the leading cause of cancer death in children with an urgent need for innovative therapies. Here we show that the cell surface oncoprotein glypican 2 (GPC2) is highly expressed on multiple lethal pediatric brain tumors, including medulloblastomas, embryonal tumors with multi-layered rosettes, other CNS embryonal tumors, as well as definable subsets of highly malignant gliomas. To target GPC2 on these pediatric brain tumors with adoptive cellular therapies and mitigate potential inflammatory neurotoxicity, we developed four mRNA chimeric antigen receptor (CAR) T cell constructs using the highly GPC2-specific fully human D3 single chain variable fragment. First, we validated and prioritized these CARs using <i>in vitro</i> cytotoxicity and T cell degranulation assays with GPC2-expressing neuroblastoma cells. Next, we expanded the testing of the two most potent GPC2-directed CAR constructs prioritized from these studies to GPC2-expressing medulloblastoma and high-grade glioma cell lines, showing significant GPC2-specific cell death in multiple models. Finally, locoregional delivery bi-weekly of two to four million GPC2-directed mRNA CAR T cells induced significant and sustained tumor regression in two orthotopic medulloblastoma models, and significantly prolonged survival in an aggressive orthotopic thalamic diffuse midline glioma model. No GPC2-directed CAR T cell related neurologic or systemic toxicity was observed. Taken together, these data show that GPC2 is a highly differentially expressed cell surface protein on multiple malignant pediatric brain tumors that can be targeted safely with local delivery of mRNA CAR T cells. <h3>One Sentence Summary</h3> Glypican 2 is expressed on the surface of multiple pediatric brain tumors and can be successfully targeted with mRNA chimeric antigen receptor T cells.
Keys to behavior sought on remote island
Authors: J. P. Callan
Journal: JAMA (1979)

For all but two months of the year refreshing trade winds air-condition a primate laboratory 90 m above sea level on the windward side of the remote West Indian island of St Kitts. There, nestled among palm trees and fields of 8-foot sugar cane is a converted "great house" where researchers are attempting to unravel some of the complexities of human behavior and the origins of man by studying monkeys in a seminatural habitat. The project is being conducted by the private Behavioral Sciences Foundation under the direction of Frank R. Ervin, MD, now professor of psychiatry at the Allan Memorial Institute, McGill University, Montreal. Bringing investigators to the difficult-to-find island inhabited by the monkeys has an advantage over primate studies that have been conducted on caged animals far removed from their native homes, noted the tall, bearded Ervin during a recent interview with<i>JAMA</i>MEDICAL NEWS. The laboratory was
Preliminary Statistical Analysis of 64 Cases of Virilism and Stein-Leventhal Syndrome
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Glucocorticoid Use and Risks of Ocular Hypertension and Glaucoma-Reply
Authors: Edeltraut Garbe
Journal: JAMA (1997)

<h3>In Reply.</h3> —Dr Macris is concerned that there was no clear-cut definition of asthma in our study population. It was our intention to investigate ocular risks of inhaled steroids in all users of these drugs, not only patients with asthma. Regardless, there is no indication that the risk of ocular hypertension or open-angle glaucoma is associated with the underlying disease, so that the exact medical diagnosis is unimportant. Macris also points out that the high doses of steroids associated with an increased risk far exceed recommended doses in the United States. These high doses follow recommendations from treatment guidelines.<sup>1</sup>Moreover, in Canada, Europe, and Australia, inhaled glucocorticoid preparations contain larger amounts of drug per puff than similar preparations in the United States. However, Macris is correct in stating that the systemic bioavailability of the inhaled steroid also depends on the delivery device. Because of the limited number of patients continuously exposed
Rheumatology
Authors: G. S. Alarcon
Journal: JAMA (1995)

The existence of rheumatology as a subspecialty has recently been questioned. How rheumatology care will be provided in the future largely depends on the demonstration that rheumatologists are more able than generalists to treat patients afflicted with rheumatic disorders effectively. Thus, rheumatologists have joined the ranks of "outcome researchers" and are increasingly involved in this type of research. Several arthritis-specific instruments have been developed; the ones most commonly used in the United States include the Health Assessment Questionnaire, the Modified Health Assessment Questionnaire, and the Arthritis Impact Measurement Scales.<sup>1</sup>In addition, generic disease instruments, such as Short Form 36, are being recommended to complement the arthritis-specific instruments because they are better at ascertaining patients' overall quality of life. The Health Assessment Questionnaire, Arthritis Impact Measurement Scales, and the Modified Health Assessment Questionnaire have been used primarily in patients with rheumatoid arthritis (RA), but adaptations of these instruments to other
Cancer Medicine
Authors: Jacob D. Bitran
Journal: JAMA (1994)

Eleven years ago, I had the opportunity to review the second edition of<i>Cancer Medicine</i>by Holland and Frei in<i>JAMA</i>. This year the third edition of this text has been published, and I am once again afforded the privilege of reviewing it. In the preface the authors state that the third edition is an entirely new book. The number of editors has been expanded from two to six, which includes Dr Donald L. Morton (surgical oncology) and Dr Ralph R. Weichselbaum (radiation oncology). Two hundred ninety-nine experts, many of whom are new, have contributed. The first 1080 pages are devoted to basic principles of cancer biology, tumor immunology, cancer etiology and epidemiology, clinical trials, prevention, screening and early detection, cancer pathology, principles of imaging, interventional radiology, endoscopy, principles of surgical oncology, radiation oncology, medical oncology, chemotherapy, chemotherapeutic agents, endocrine therapy, biologics and biotherapeutics, bone marrow transplantation, psychooncology, oncology nursing,
Heart Failure After Myocardial Infarction - A Population-Based Study
Authors: Jens P Hellermann, Steven J Jacobsen, Barbara P Yawn, Susan Weston, Margaret M Redfield, Richard R Rodeheffer, Guy S Reeder, Veronique L Roger
Journal: Circulation (2001)

P46 While heart failure (HF), an emerging epidemic, complicates myocardial infarction (MI), little is known on the predictors of HF post-MI, in particular the impact of reperfusion therapy. This population-based study was undertaken to examine the association between clinical characteristics and post-MI HF between 1979 and 1994. Hospitalized incident MIs were validated using enzymes, chest pain, and Minnesota coding of the ECG. Framingham criteria were used to ascertain both in- and outpatient HF. Proportional hazard regression was used to identify predictors of CHF. In the study period, 1657 patients (pts.) (mean age 67.2 ± 13.9 years, 43% women) had an incident MI. History of diabetes, hypertension and prior HF was found in 19%, 54% and 11% of pts respectively. After 5 years, 43% of pts had experienced HF. Factors independently associated with HF were (see table). There was a 2% decline per year in occurrence of HF. Adding reperfusion therapy in the model attenuated the association between year and HF (adjusted RR for reperfusion 0.67, 95% CI 0.53, 0.84, p=0.006; adjusted for year 0.99; 95% CI 0.97, 1.01, p=0.37). Thus, while remaining frequent post-MI CHF has declined over time. Reperfusion therapy accounted for most of the effect of year. Table 1.
Inversionsgastroskopie
Authors: R. Ottenjann
Journal: Endoscopy (1970)

Gastroscopy with inversion of the tip of the instrument is just a few years old. Inversion gastroscopy should be performed as the last procedure in examining the stomach. The method of inversion with the different models is described. Whenever the clinical or radiological diagnosis of a circumscribed lesion in the proximal third of the stomach or of achalasia is suggested inversion gastroscopy is indicated. The examination should be performed reluctantly in major processes of the greater curvature. Complications are rare, there were a few cases with problems in retracting the instrument after inversion.
An Address Delivered at the Opening of the Section of Medicine
Authors: J. W. T. Smith
Journal: BMJ (1884)

gical wards, and designated as erysipelas, pyaemia, ichoremia, and septicemia.Such is the septicaemic theory as to the nature of puerperal fever.Those who hold it, look on the disease as preventable, and assert that its occurrence is due either to ignorance of the precautions neces- sary to prevent it, or to failure in seeing that such precautions are rigorously carried out.These precautions are of a very elaborate character.They have been very fully set out in a paper read before the New York Academy of Medicine in December last, by Dr.Gaillard Thomas.They are to be put in force in private dwellings of all classes, as well as in hospitals.When a confinement is expected, the patient's room is to be carefully prepared, all curtains and upholstery to be removed, the ceilings and floors are to be washed with' a solution of carbolic acid or bichloride of mercury, the bed- stead and mattress to be sponged with the same solution.The nurses and physician are to take care that all their clothing is free from septic infection.If they have been exposed to the effluvia of septic diseases, such as typhus or erysipelas, their clothing is to be changed, and their bodies thoroughly sponged with a saturated solution of boracic acid.As labour sets in, the nurse is to wash her hands, re- move the dirt from under her nails, and give the patient an anti-
Empty Soup
Authors: Jack Coulehan
Journal: Annals of Internal Medicine (1998)

Ad Libitum1 September 1998Empty SoupJack Coulehan, MDJack Coulehan, MDSetauket, NY 11733Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-129-5-199809010-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail We made a soup last weekfrom turnips and thistles-that's how poor we've become.In the mill, our machineryis down-we sweep the floorall week with politics.Better to be a free manthan a cog-stories like thisare spice for our pot.In our lives, too-the voiceof the Russian nationis drab and heroiclike a long family tripafter a death-so muchto do, so little time.Empty soup-that's whatthe woman from Novotnyserved for her supper.Yes, I am grateful,she said, even for the thistlesin the cracks of my life. Author, Article, and Disclosure InformationAffiliations: Setauket, NY 11733Corresponding Author: Jack Coulehan, MD, 4 Townsend Court, Setauket, NY 11733. Previousarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1998Volume 129, Issue 5Page: 421 ePublished: 15 August 2000 Issue Published: 1 September 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Do frail, disabled, poor, and very old Medicare beneficiaries have higher hospital charges?
Authors: S. F. Jencks
Journal: JAMA (1987)

To determine whether basing payments on diagnosis related groups (DRGs) results in mispayment for certain classes of patients, we examined the relation between total Medicare charges per hospitalization and eight beneficiary characteristics (including admission from a nursing home, extreme age, Medicaid enrollment, and disability). We controlled for the hospital in which care was given and the DRG to which the discharge was assigned. The largest effects were that average charges were 6.7% higher for beneficiaries who were disabled before the age of 65 years, and 6.2% higher for patients admitted from a nursing home; charges were 1.5% lower for Medicare beneficiaries who were also enrolled in Medicaid, 3.8% higher for those older than 80 years, and 1.3% lower for those older than 85 years compared with those aged from 80 to 84 years. Because these differences are very small compared with the average variation within DRGs, we conclude that using these beneficiary characteristics in the DRG classification system would only slightly improve DRGs. Medicare's DRG-based payments seem to be substantially equitable with regard to these beneficiary characteristics. (<i>JAMA</i>1987;257:198-202)
Adjuvant chemotherapy of breast cancer
Authors: W. A. Check
Journal: JAMA (1980)

Because of remarkable early success in trials of adjuvant chemotherapy for breast cancer, the National Institutes of Health recently sponsored a consensus conference to evaluate the data in this field and to examine "the impact of such trials on general medical practice." Clear-cut recommendations emerged after two days of presentations and discussions all right, but several conference attendees thought the consensus document was so general as to limit its usefulness. In the end, the recommendations' primary value may be to alert physicians to consider seriously adjuvant chemotherapy for many of their breast cancer patients and to help define which patients are most likely to receive benefit. In addition, since treatment decisions in this area are not always clear, the panel counseled that "optimal care requires frank and open communication between the physician and patient about the options available." <h3>Premenopausal Patients</h3> The premenopausal woman with breast cancer that has spread to
TCT-169 BIOFLOW-III an all comers registry with a Sirolimus Eluting Stent, Presentation of One Year Target Lesion Failure Data
Authors: Johannes Waltenberger, Stefan Hoffmann, Johannes Brachmann, Jan Van der Heyden, Gert Richardt, Ole Frobert, Markus Seige, Otmar Pachinger, Andrejs Erglis, Willem Dewilde
Journal: Journal of the American College of Cardiology (2013)
Amer J of Clinical Nutrition, New York
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Practical Surgery: A Work for the General Practitioner.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CONTINUING MEDICAL EDUCATION
Journal: JAMA (1960)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
JAMES HENRY ETHERIDGE, A.M., M.D.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal