tbuckley/cabot-search huggingface dataset:
Gas gangrene complicating fracture of the tibia
Authors: O. E. Aufranc
Journal: JAMA (1969)

Dr. Arthur L. Boland: A 29-year-old man, an iron worker, whose condition was diagnosed as gas gangrene, was transferred from a local hospital; it was his first admission to Children's Hospital Medical Center. Two days earlier, when he had been struck by a rotating truck wheel, he sustained an open fracture of his right tibia and a wringer-type soft tissue injury of the leg. When he was admitted to the other hospital, the right foot was pulseless; however, circulation returned immediately upon closed reduction of the fracture in the accident room. The wounds were then debrided and closed primarily in the operating room, and the tibial fracture was held with a Lottes nail. He was treated with intravenous administration of aqueous potassium penicillin G, streptomycin, tetanus toxoid, and hyperimmune serum. The patient's temperature was 104 F (40.0 C), 24 hours later, and the calf of his right leg was severely
IN THIS ISSUE
Journal: JNCI Journal of the National Cancer Institute (2009)

Guidelines for Metastatic Breast Cancer TreatmentCompared with early-stage breast cancer, little is known about treating metastatic breast cancer with chemotherapy.Specifically, whether to use combination or single-agent therapy is a controversial issue.The European School of Oncology Metastatic Breast Cancer Task Force held an open debate on the relative benefits of combination vs sequential therapy at the 6th European Breast Cancer Conference.Cardoso et al. (p.1174) report the recommendations of the task force.Based on existing data, the task force recommends sequential rounds of chemotherapy with a single agent for patients with advanced metastatic breast cancer without rapid progression or life-threatening metastasis, and for those who do not need rapid symptom or disease control.The choice between using combination and sequential single-agent chemotherapy should be based on patient and disease related factors.More research is needed to examine quality of life with treatment and to identify factors that can be used to help guide treatment decisions.
On the Use of Ether and Etherised Cod-Liver Oil in the Treatment of Phthisis
Authors: B. W. Foster
Journal: BMJ (1868)

Let it not be supposed for a moment, that I deny the presence in many of such cases of other, and it may be important, changes in the state of the uterus, aggravating and increasing, as they often do, the original mischief; but my experience has taught me that they are, for the most part, secondary, not only in effect, but in importance.And it is, I be- lieve, substantially true that, in nine cases out of ten, " uterine lameness" is due to flexion and analogous displacements of the organ.Lastly, I would not have it supposed that I disregard the ovary in regard to the question of lameness.I have met with several cases in which difficulty in locomotion was connected with ovaritis in various forms and degrees; but, compared with uterine lameness, ovarian lame- ness is, I believe, comparatively rare.
Injections-Reply
Authors: Harold Laufman
Journal: JAMA (1977)

<h3>In Reply.—</h3> I believe Dr Forsythe is correct in his comment that it is not good practice to administer injections in office practice when oral medications are available, both for reasons of risk of anaphylaxis and for patient economy. I thought I alluded to this point when I commented that the physician who asked the question certainly was giving a large number of injections to his patients. The low incidence of needle abscesses is obviously no excuse for the overuse of injections. I believe Dr Forsythe's commentary is important, but I would not consider my original reply inappropriate. It answered a specific question and was not intended to be a verbal scolding. Yet, I do agree that a scolding is in order.
Expression of the interferon-induced antiviral protein MXA is inhibited in vitro by the hepatitis B virus (HBV) capsid protein *INSERM U370, CHU Necker; Paris; ILaboratoire de Virologie, Hopital St Vincent de Paul, Universit� Ren� Descartes, Paris, France; $Ciba-Geigy; Base; Switzerland
Journal: Hepatology (1995)
Arteriosclerotic heart disease in Roseto, Pennsylvania
Authors: A. Keys
Journal: JAMA (1966)

Data from a recent electrocardiographic survey provide no support for the claim that people in the town of Roseto, Pa, are relatively protected from myocardial infarction. The evidence offered from death data for 1955 to 1961 does not prove that in those years the people of Roseto differed significantly from average US white residents in the rate of death from arteriosclerotic heart disease. Consideration of the diet suggests that in the past Rosetans should have enjoyed considerable protection from arteriosclerotic heart disease. Failure to establish that fact could be expected from the inadequate size of the population concerned. There is no basis to propose a protective effect of the emotional climate of Roseto.
Clinical Immunology
Authors: Stanley F. Hampton
Journal: JAMA (1972)

This book embodies 22 chapters, the majority of which have to do with diseases not commonly encountered by the practicing allergist, the knowledge of which, however, should make any clinician a better one. The only criticism I might offer would be the somewhat meager space devoted to allergic rhinitis, asthma, urticaria, and contact and atopic dermatitis, the most commonly encountered diseases in the clinical practice of allergy. These remarks are not intended to detract from the values of the book, which is most informative. The first chapter, "Immune Response," includes a comprehensive, yet concise, description of immunoglobulin structures (with an excellent table of the characteristics of IgG, IgA, IgM, IgD and IgE), the complement system, chemical mediators, and blood group substances. It is the only chapter, however, that does not have numbered references in the text. Other chapters discuss the immune responses in diseases of the kidney, including experimental and
Incidence of hepatocellular carcinoma in chronic Hepatitis B and C: A prospective study of 251 patients
Authors: S TAKANO
Journal: Hepatology (1995)

The incidence of hepatocellular carcinoma (HCC) was prospectively studied in 251 chronic hepatitis patients, and was compared between the 127 cases of hepatitis B and 124 cases of hepatitis C. All patients were diagnosed by needle biopsy on entering the study, and the cases consisted of chronic persistent hepatitis (CPH), chronic active hepatitis (CAH)2a, and CAH2b (cirrhosis was not included). Of the cases of chronic hepatitis B, 5 cases of HCC (3.9%) were detected; among the chronic hepatitis C cases, 13 cases (10.4%) were detected. Thus, although the mean follow-up periods were in the same range, the incidence of hepatocellular carcinoma was 2.7 times higher in hepatitis C than in hepatitis B (χ2 = 3.116, P < .05). Using the Kaplan-Meier method, the incidence of HCC was significantly higher in chronic hepatitis C (P = .0194, generalized Wilcoxon test). In hepatitis C, the incubation period until HCC was detected was shorter when the liver disease was more advanced. Such a tendency was not observed in hepatitis B. In the 13 cases of HCC occurring in chronic hepatitis C, noncirrhotic liver was seen in only 1 case (7.7%), whereas 2 of the 5 cases of HCC (40%) in chronic hepatitis B were noncirrhotic. The prevalence of hepatitis C virus (HCV) genotypes II and III was the same in the total followed cases and HCC cases.
NEWER ASPECTS OF THE RICKETS PROBLEM
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Saratoga Meetings.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Loss of Runx1 Perturbs Adult Hematopoiesis and Is Associated with a Myeloproliferative Phenotype.
Authors: Joseph D. Growney, Hirokazu Shigematsu, Zhe Li, Benjamin H. Lee, Jennifer Adelsperger, Rebecca Rowan, David P. Curley, Koichi Akashi, Ifor R. Williams, Nancy A. Speck, D. Gary Gilliland
Journal: Blood (2004)
Computerized management of the outpatient diabetic
Authors: R. E. Bolinger
Journal: JAMA (1971)

Examination of a semi-automated management system for the outpatient diabetic includes criteria for its performance, and a management module based on information obtained at the patient visit along with examples of the output prescription. The changes in insulin recommended by the computer agreed with those of the physician in most instances (<i>r</i>= 0.98), and in no instance did the computer make hazardous recommendations.
Acute Pericarditis due to Histoplasma Capsulatum
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction: Any Questions
Journal: BMJ (1983)

where the candidate is the last author seems to increase and thc proportion of those in which he is first author to decrease (fig 2).The total number of papers published each year for the four candi- dates was: 1, 10.40; 2, 20.53; 3, 3.55; and 4 2.59 and this was clearl, increased by time (fig 3).
Abstract LB-034: Myc instructs and maintains pancreatic adenocarcinoma phenotype
Authors: Nicole M. Sodir, Roderik M. Kortlever, Valentin J.A. Barthet, Luca Pellegrinet, Tania Campos, Steven Kupczak, Laura Soucek, Mark J. Arends, Trevor D. Littlewood, Gerard I. Evan
Journal: Cancer Research (2019)

Abstract Pancreatic ductal adenocarcinoma (PDAC) sporadically develops from pre-cancerous pancreatic intraepithelial neoplasia (PanIN). It has a very poor prognosis and lacks effective therapies. Expression of the pleiotropic transcription factor Myc is deregulated in the majority of human cancers, including PDAC. Using a rapidly and reversibly switchable genetic mouse model to toggle Myc activity, we show that Myc drives immediate transition of indolent KRasG12D-induced PanINs into aggressive pancreatic adenocarcinomas that share all the signature features of spontaneous human PDAC. Myc induces a distinct set of instructive signals, some hitherto unknown, that together orchestrate coordinated changes in the multiple, distinct stromal and inflammatory cell types that generate the characteristic PDAC stroma. We also demonstrate that continued Myc activity is required for PDAC maintenance - Myc deactivation immediately triggers meticulous disassembly of PDAC, including its attendant stroma. Thus, both the formation and deconstruction of the complex PDAC phenotype can be mediated by a single, reversible molecular switch. We have also identified a previously unknown Myc-dependent GAS6-AXL pathway that is required for stromal changes characteristic of PDAC. Using the same pre-clinical mouse PDAC model, we show that TP-0903, a specific inhibitor of AXL kinase, profoundly blocks Myc-induced influx of neutrophils into PanINs and B220+ lymphoid cells into the PanIN periphery. This significantly retards Myc-driven stellate cell activation and proliferation and impedes PDAC growth. Hence, the GAS6-AXL-mediated signaling pathway is a promising therapeutic target for pancreatic ductal adenocarcinoma. TP-0903 is currently in a Phase I/Ib clinical study in in patients with solid tumors, including PDAC. Citation Format: Nicole M. Sodir, Roderik M. Kortlever, Valentin J.A. Barthet, Luca Pellegrinet, Tania Campos, Steven Kupczak, Laura Soucek, Mark J. Arends, Trevor D. Littlewood, Gerard I. Evan. Myc instructs and maintains pancreatic adenocarcinoma phenotype [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr LB-034.
THE ACTION OF THE SPECIFIC DIURETICS
Journal: JAMA (1929)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medicine—More Than Molecules and Money
Authors: Erwin O. Hirsch
Journal: JAMA (1995)

<h3>To the Editor.</h3> —In connection with Dr Eisenberg's<sup>1</sup>thoughtful analysis of the problems facing medicine today, I wonder whether it may not be useful to draw a distinction between medicine, a body of knowledge, and the practice of medicine, the application of this knowledge. The body of knowledge as set forth in any textbook of medicine can be properly called a science because it is organized to reflect a theory and because it has been acquired by scientific methods. The theory is the one formulated by Virchow over a century ago that states illness is the manifestation of changes in the structure or function of organs, tissues, and cells; the scientific methods range from the systematic analysis of the relationship between clinical observations and pathological findings to test-tube experiments. It is the pride of the practice of medicine that it is based not merely on a body of knowledge
Serratia marcescens
Authors: Conrad J. Wilkowske
Journal: JAMA (1970)

Serratia marcescens isolation can be accomplished more frequently when biochemical criteria are used to identify the Enterobacteriaceae. During a 14-month period, 176 strains of S marcescens were isolated, predominantly from hospitalized patients. Generally, these organisms were resistant to many antibiotics. Underlying factors were preceding antibiotic or inhalation therapy and surgery and instrumentation of the urinary tract. Most strains confined to urine or sputum samples caused infections of low morbidity, but when there was associated wound or blood-stream infection the death rates were high. The isolation of S marcescens should not be ignored because it is a life-threatening complication for certain hospitalized patients.
Röntgendiagnostik der Knochen- und Gelenkkrankheiten
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Utilization of Adipose Tissue Biopsy in Characterizing Human Halogenated Hydrocarbon Exposure
Authors: Henry A. Anderson
Journal: Environmental Health Perspectives (1985)

Halogenated hydrocarbons have been successfully utilized for pest control in agriculture and public health. In industry, the polychlorinated biphenyls (PCBs) have been particularly useful. Unfortunately, residues have proven persistent and have been found widely dispersed in the environment. Because they have chemical properties that favor bioaccumulation, it is not surprising that many have been identified in animals and man. Such findings prompted public health concern and initiated review of potential adverse health impacts. In many instances this process has led to total prohibition of use or strict limitations. Highly lipophilic, the primary accumulation site in humans is adipose tissue. Analysis of adipose samples remains the preferred biologic index for estimating exposure. Improved instrumentation has lowered the limit of detection and improved the accuracy of quantification. Accumulated population experience has helped develop understanding of the dynamics of tissue partitioning in humans. Once such relationships have been adequately described, other less invasive procedures may be more confidently used for general surveillance purposes. Whenever adipose tissue is obtained, the blood compartment should also be sampled and the relationship reported. We have only begun to investigate the resulting partition ratio as an investigative tool.
A New Approach to Evaluate the Impact of Climate on Human Mortality
Authors: Laurence S. Kalkstein
Journal: Environmental Health Perspectives (1991)

The objective of this study is to introduce a new procedure to determine the impact of climate on human mortality with the use of a synoptic climatological approach. The holistic nature of synoptic categories allows for the simultaneous evaluation of numerous weather elements as they realistically appear within air masses. In addition, this approach allows for a better distinction between pollution-induced mortality and weather-induced mortality. A synoptic categorization was performed for St. Louis, Missouri, and each category was evaluated in terms of its mean daily mortality. Of 10 summer categories found in St. Louis, one possessed the highest mean mortality by far, and 8 of the top 10 mortality days in St. Louis occurred when this category was present. Further analysis determined that long, consecutive day periods of this hot, oppressive category are associated with a continuing rise in mortality. It was determined that the procedure described here has the potential to be used in a weather/mortality watch-warning system. Finally, it appears that day-to-day mortality fluctuations are much more sensitive to weather than to pollution concentrations, as the oppressive category associated with the greatest mortality possessed levels of six major pollutants that were not noteworthy.