tbuckley/cabot-search huggingface dataset:
Editorial Board
Authors: Lori Zeltser, Simone Brioschi, Vincent Peng, Marco Colonna, R Fields, J Dutta, Donald Pfaff, Helen Reviews, Amy Reichelt, Dominic Hare, Timothy Bussey, Lisa Saksida, Anna Bludau, Melanie Royer, Gunter Meister, Inga Neumann, Rohit Menon, Simon Hanslmayr, Nikolai Axmacher, Cory Inman, Vishnu Cuddapah, Shirley Zhang, Amita Sehgal, Moran Furman, Jessica Miles, Fred Kop, Patrick Scheffmann, Silvia Arber, Anders Björklund, J Paul Bolam, Sarah Bottjer, Rui Costa, Ann Marie, Craig Barry, J Dickson, Chris Doe, Craig Garner, Yukiko Goda, Kenneth Harris, Nancy Ip, Meyer Jackson, Maria Karayiorgou, Robert Malenka, Mark Mattson, Freda Miller, Richard Morris, Maiken Nedergaard, Eric Nestler, Anna Roe, Hitoshi Sakano, Greg Stuart, Marc Tessier-Lavigne, Chris Walsh
Journal: Trends in Neurosciences (2019)
A multicenter randomized controlled trial to evaluate the efficacy of surgery vs. radiofrequency ablation for small hepatocellular carcinoma (SURF trial).
Authors: Namiki Izumi, Kiyoshi Hasegawa, Yujiro Nishioka, Tadatoshi Takayama, Naoki Yamanaka, Masatoshi Kudo, Mitsuo Shimada, Masahumi Inomata, Shuichi Kaneko, Hideo Baba, Kazuhiko Koike, Masao Omata, Masatoshi Makuuchi, Yutaka Matsuyama, Norihiro Kokudo
Journal: Journal of Clinical Oncology (2019)

4002 Background: Surgery (SUR) and radiofrequency ablation (RFA) are both known to be effective therapy for treating patients with small oligonodular hepatocellular carcinoma (HCC), however there is only insufficient evidence about which therapy is more preferred approach. This randomized controlled trial was designed to prospectively compare the efficacy of SUR and RFA as the first approach to primary HCC. Methods: In this open-label trial undertaken at 49 hospital in Japan, we recruited patients having primary HCC with tumor foci numbering less than 3, each measuring 3 cm or less, Child-Pugh score of 7 or less, ages between 20 and 79 year. Before randomization, technical and liver functional feasibility for both treatment arms were confirmed by joint chart review by surgeons and hepatologists. Patients were then randomly assigned in a 1:1 ratio to undergo SUR or RFA, stratified by age, infection of hepatitis-C virus, number of tumors, tumor size and institution. The primary endpoint was recurrence free survival (RFS) and overall survival (OS). Results: Between April 2009 and August 2015, total 308 patients were enrolled to this trial. Because of ineligibility 15 patients were excluded, therefore 145 patients underwent SUR and 148 patients underwent RFA finally. There was no perioperative mortality. Under the median follow-up of 5 years, the 3-year RFS of patients underwent SUR and RFA was 49.8%, 47.7%, respectively (hazard ration [HR] 0.96, 95% CI 0.72-1.28; p = 0.793). OS will be analyzed and published after two years. Conclusions: SUR and RFA were both safe therapeutic approaches and provided equally RFS for early stage HCC smaller than 3 cm. Clinical trial information: UMIN000001795.
Retraction—validation of gene signatures that predict the response of breast cancer to neoadjuvant chemotherapy: a substudy of the EORTC 10994/BIG 00-01 clinical trial
Authors: Hervé Bonnefoi, Anil Potti, Mauro Delorenzi, Louis Mauriac, Mario Campone, Michèle Tubiana-Hulin, Thierry Petit, Philippe Rouanet, Jacek Jassem, Emmanuel Blot, Véronique Becette, Pierre Farmer, Sylvie André, Chaitanya R Acharya, Sayan Mukherjee, David Cameron, Jonas Bergh, Joseph R Nevins, Richard D Iggo
Journal: The Lancet Oncology (2011)
Leads from the MMWR. Recommendations for preventing transmission of infection with human T-lymphotropic virus type III/lymphadenopathy-associated virus during invasive procedures
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Acetaminophen-induced acute liver failure: Results of a United States multicenter, prospective study
Authors: William J. Holubek, Susanne Kalman, Robert S. Hoffman
Journal: Hepatology (2006)

To the Editor: We read with interest the recent article by Larson et al.1 that concluded the leading cause of acetaminophen hepatotoxicity in patients with acute liver failure in the United States is unintentional overdose. We would like to commend all the authors on their extensive effort and data collection. However, in addition to the limitations listed in O'Grady's commentary,2 we have some concerns about the inclusion criteria and the definition of unintentional ingestion. The authors assigned acetaminophen as the cause of acute liver failure if any level of acetaminophen was detected in the serum, but their exclusion criteria did not specifically include hepatitis C, hepatotoxic drug exposure, or viral etiologies. These encephalopathic patients were then defined as an unintentional ingestion if they had a history, provided by an unspecified person, of a "multiple-timepoint ingestion to relieve pain or other somatic symptoms with denial of suicidal intent." Using this criteria, patients with undiagnosed acute hepatitis who take therapeutic doses of acetaminophen for analgesia would be assigned to the unintentional ingestion group. This presents both a large recall and selection bias. Although it is important to remind physicians and the general public of the potential devastating results of supratherapeutic or concomitant use of acetaminophen products, given the assumptions and methods employed by the authors, we believe their conclusions are somewhat misleading. William J. Holubek M.D.*, Susanne Kalman M.D. , Robert S. Hoffman M.D.*, * Department of Emergency Medicine, New York University School of Medicine, New York, NY, Department of Emergency Medicine, University of Maryland School of Medicine, Baltimore, MD.
BAFF selectively enhances the survival of plasmablasts generated from human memory B cells
Authors: Danielle T. Avery, Susan L. Kalled, Julia I. Ellyard, Christine Ambrose, Sarah A. Bixler, Marilyn Thien, Robert Brink, Fabienne Mackay, Philip D. Hodgkin, Stuart G. Tangye
Journal: Journal of Clinical Investigation (2003)

The generation of Ig-secreting cells (ISCs) from memory B cells requires interactions between antigen-specific (Ag-specific) B cells, T cells, and dendritic cells. This process must be strictly regulated to ensure sufficient humoral immunity while avoiding production of pathogenic autoantibodies. BAFF, a member of the TNF family, is a key regulator of B cell homeostasis. BAFF exerts its effect by binding to three receptors — transmembrane activator of and CAML interactor (TACI), B cell maturation antigen (BCMA), and BAFF receptor (BAFF-R). To elucidate the contribution of BAFF to the differentiation of B cells into ISCs, we tracked the fate of human memory B cells stimulated with BAFF or CD40L. BAFF and CD40L significantly increased the overall number of surviving B cells. This was achieved via distinct mechanisms. CD40L induced proliferation of nondifferentiated blasts, while BAFF prevented apoptosis of ISCs without enhancing proliferation. The altered responsiveness of activated memory B cells to CD40L and BAFF correlated with changes in surface phenotype such that expression of CD40 and BAFF-R were reduced on ISCs while BCMA was induced. These results suggest BAFF may enhance humoral immunity in vivo by promoting survival of ISCs via a BCMA-dependent mechanism. These findings have wide-ranging implications for the treatment of human immunodeficiencies as well as autoimmune diseases.
Disturbances of the Heart
Journal: JAMA (2013)

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Cervical analgesic discography. A new test for the definitive diagnosis of the painful-disk syndrome
Authors: D. A. Roth
Journal: JAMA (1976)

The cervical discogenic (painful-disk) syndrome consists of scapular pain radiating into the head, shoulder, and upper arm, often associated with paresthesias but without neurologic deficit. Plain roentgenograms or myelograms are normal or show degenerative changes. Positive-contrast discography has been useful but is subject to a high percentage of false-positive results roentgenographically and nonspecific pain patterns clinically. Analgesic discography more precisely confirms the diagnosis and more accurately locates the pain-producing disk. Injection of a local anesthetic into a painful disk produces transient symptomatic relief and full neck mobility. Its use during a two-year period in 71 consecutive discogenic patients followed by anterior cervical fusion resulted in a 93% excellent or good recovery rate. Analgesic discography is the most effective test for diagnosis and location in the painful-disk syndrome. (<i>JAMA</i>235:1713-1714, 1976)
MADRID
Journal: JAMA (1925)

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Tough
Authors: David B. Frens
Journal: JAMA (1993)

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THE MILK SUPPLY OF CITIES AND TOWNS.
Journal: JAMA (1903)

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Systematic Reviews
Authors: Samuel Shapiro
Journal: JAMA (1995)

This book is a collection of papers presented at a meeting convened in 1993 to "discuss aspects of the science of reviewing clinical research." As such it suffers from the usual problems of published proceedings: a lack of cohesion combined with both inadequate coverage and redundancy. Most notably it offers virtually no theoretical foundation for the advocacy of systematic reviews. There is even a lack of clarity as to what is meant by the term. "Systematic review" is preferred to "meta-analysis" because an overall summary statistic is not always attainable, but in many places in the text there is elision from the one term to the other. Meta-analysis, however, apparently remains the "gold standard." Yet hardly any distinction is made between the meta-analysis of controlled trials (for which the approach, conceptually, is of value) and of nonexperimental (observational) data (for which the approach is not valid at all). The general
Abstract 18497: Hospital-based Exercise Training Program Post Coronary Artery Bypass Graft Surgery: Impact of Once and Twice Daily Exercise Program on Cardiac Autonomic Modulation
Authors: Renata Mendes, Camila B Pantoni, Rodrigo P Simões, Luciana Di Thommazo-Luporini, Flávia C Caruso, Erika Z Kabbach, Audrey Borghi-Silva
Journal: Circulation (2015)

Introduction: Coronary artery bypass surgery (CABG) patients with postoperative decreased cardiac autonomic modulation (CAM) have a higher mortality rate and although cardiovascular rehabilitation and exercises have substantial benefits in CAM, there is a paucity of information about its effects considering a possible "dose-dependent” autonomic adaptation in a hospital-based exercise program. The aim was to evaluate the impact of once daily versus twice daily dosing regimens of hospital-based exercise training on CAM in post CABG patients. Hypothesis: We hypothesized that there is a dose-dependent exercise adaptation on CAM and greater benefit to twice daily exercise group. Methods: Thirty-seven patients post-CABG were divided into: GEX1 (n = 12) and GEX2 (n = 11), composed of patients who underwent exercises one and two daily sessions, respectively; and of a control group (CG, n = 14) who received usual care (respiratory therapy). GEX patients initiated the exercises on post-operative day 1 (PO1), following a whole progressive program until discharge. CAM was assessed by indices of heart rate variability (HRV) analyzed from heart rate and R-R intervals signals recording at rest during 10 minutes on PO1 (baseline) and discharge time. Results: At the time of discharge after the hospital rehabilitation conclusion, GEX2 presented higher values of rMSSD index, representative of parasympathetic modulation, and also higher values of RRtri, TINN and STDRR indices, representative of overall variability of RRi compared to GC, respectively (rMSSD: 7.5±1.9 vs 5.2±1.8 ms; RRtri: 3.2±1.4 vs 2.0±0.7ms; TINN: 46.0±30.5 vs 25.7±11.0 ms and STDRR: 10.0±6.3 vs 5.4±3.3 ms), while GEX1 presented only higher values of rMSSD compared to CG (rMSSD: 7.8±2.5 vs 5.2±1.8 ms). However, no differences were observed between groups on HRV baseline and at discharge time between groups GEX1 and GEX2. Conclusion: Our results suggested that twice daily hospital-based exercise program stimulated more favorably the cardiac autonomic nervous system adaptations in patients post-CABG. Although a daily exercise session promotes beneficial adaptations, two sessions should be encouraged to additional benefits in the cardiac autonomic modulation FAPESP 2015/2015 / 16730-3.
A systematic review of pharmacogenetic studies on the response to biologics in patients with psoriasis
Authors: L.J. van Vugt, J.M.P.A. van den Reek, M.J.H. Coenen, E.M.G.J. de Jong
Journal: British Journal of Dermatology (2018)

Psoriasis is a common skin disease in which the body produces too much of a protein called 'tumour necrosis factor alpha' (TNF‐alpha) which in turn causes inflammation. Biologics are relatively new, powerful drugs used for treating moderate to severe psoriasis due to their ability to reduce the activity of TNF‐alpha. There are several different types of biologic and finding the best one for the individual patient is a process of trial and error, which may lead to a long period with treatment not working as well as hoped and unnecessary costs. Different people's genes (genetic variants) might explain why not everyone responds the same way to a biologic, and might also help predict whether a specific biologic is likely to be successful for a patient. This area of medicine is known as pharmacogenetics. This study, from the Netherlands, is a review of other published studies, looking at the association between genetic variants and effectiveness of treatment with the different biologics. 26 studies were included in the review, looking at the biologics dalimumab, etanercept, infliximab and ustekinumab. No studies on two other biologics, secukinumab or ixekizumab, were identified. Many of the studies focused on variants in genes related to the working mechanisms of TNF‐alpha. Associations between some variants of TNF‐alpha and biologics were found in some studies, but often these results were conflicting in other studies. The authors conclude that pharmacogenetic studies in psoriasis have differing results. The genetic variant HLA‐Cw6 may be promising as a predictor for efficacy of ustekinumab, but larger studies are needed to confirm this. Large scale searches for genetic biomarkers are needed to uncover the complete genetic background of biologics treatment outcome.
Abstracts
Journal: Annals of the Rheumatic Diseases (1963)

In an attempt to confirm the numerous reports suggesting that the incidence and severity of rheumatic fever have declined during the past two decades the authors have reviewed the records of all (792) patients with first attacks of confirmed rheumatic fever admitted to Bellevue Hospital, New York, between 1935 and 1958; these were examined for the three 8-year periods 1935-42, 1943-50, and 1951-58, during which 368, 195, and 229 cases respectively were seen.The three groups did not differ significantly in regard to age (peak incidence 6 to 10 years) and sex distribution, but racially there was a greater proportion of Puerto Rican patients in the third period, reflecting the population change in this district of New York.The three chief manifestations considered were arthritis, chorea, and carditis.The results were extensively analysed according to age, sex, race, period of illness before admission, and length of stay in hospital, and also in regard to the various com- plications, taken singly and in the different possible combinations, and are presented in ten tables.They show that, for the three periods respectively, the mor- tality during stay in hospital was 3 5, 2 6, and 0 9 per cent.; the incidence of marked cardiac enlargement was 7-9, 7-7, and 3-1 per cent. of pericarditis 5 4, 7 7, and 3 * 5 per cent., and of congestive heart failure 7 -3, 7 -7, and 6-6 per cent.Chorea showed a marked fall in incidence over the period, the figures being 28 5, 24-6, and 12 7 per cent.respectively.The over-all incidence of carditis was 46 5, 49 7, and 38-4 per cent.respectively, a barely significant decrease, but when the 182 patients with chorea alone were excluded the difference became more copyright.
Editorial: The cause of death
Authors: H. H. Hussey
Journal: JAMA (1974)

The first manuscript in which I shared the work 40 years ago bore the same title as this editorial. At that time Yater and I<sup>1</sup>concluded that The death certificate is an important document. The inaccuracy of many death certificates detracts greatly from their value. Clinical determination of the causes of death is often difficult, the general percentage of correct diagnoses being probably less than 50%. When two diseases coexist, it may be difficult at times to decide which is the principal cause of death and which the contributory. The exact mechanism of death in many diseases is not fully known. Intravascular infection, pneumonia, and tuberculosis are the main contributory or terminal states as shown by a study of 220 necropsies. Now, 40 years later, all the foregoing statements (with the exception of the one about tuberculosis) probably cannot be challenged. Consider especially the inaccuracy of death certificates. From time
Occupational Cancer in France: Epidemiology, Toxicology, Prevention, and Compensation
Authors: J. C. Aubrun, S. Binet, C. Bozec, P. Brochard, S. Dimerman, B. Fontaine, P. Guenel, D. Luce, Y. Martinet, J. J. Moulin, J. M. Mur, M. Pietruszynski, C. Vallayer
Journal: Environmental Health Perspectives (1999)