tbuckley/cabot-search huggingface dataset:
Hematology: 'Sustained Explosion of Knowledge'
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mammographic Screening
Authors: John K. Cherry
Journal: JAMA (1994)

<h3>To the Editor.</h3> —The Editorial by Drs Davis and Love<sup>1</sup>contains several points that warrant comment. First, they accurately state that "diagnostic mammographic evaluation is indicated at any age if a woman has a lump." Although accurate, this statement should be accompanied by the proviso that the mammographic evaluation in this circumstance is directed solely to the contralateral breast and to those portions of the ipsilateral breast outside the confines of the palpable mass. Mammograms cannot be used in the evaluation of a palpable breast mass given the "false-normal" rate, as well as the ability to perform needle aspiration or excisional biopsy, and thereby establish histologic diagnosis. Second, while it is also true that no study has yet demonstrated an improvement in the death rate among younger women through the use of mammography, such a study that would meet the standards necessary for statistical validity (ie, comprising the appropriate
Inotuzumab Ozogamicin in Combination with Low-Intensity Chemotherapy (mini-hyper-CVD) As Frontline Therapy for Older Patients (≥60 years) with Acute Lymphoblastic Leukemia (ALL)
Authors: Elias Jabbour, Susan O'Brien, Deborah A. Thomas, Koji Sasaki, Guillermo Garcia-Manero, Farhad Ravandi, Gautam Borthakur, Sergernne York, Rebecca Garris, Jorge E. Cortes, Hagop M. Kantarjian
Journal: Blood (2014)
Personal Exposure to JP-8 Jet Fuel Vapors and Exhaust at Air Force Bases
Authors: Joachim D. Pleil, Leslie B. Smith, Sanford D. Zelnick
Journal: Environmental Health Perspectives (2000)

JP-8 jet fuel (similar to commercial/international jet A-1 fuel) is the standard military fuel for all types of vehicles, including the U.S. Air Force aircraft inventory. As such, JP-8 presents the most common chemical exposure in the Air Force, particularly for flight and ground crew personnel during preflight operations and for maintenance personnel performing routine tasks. Personal exposure at an Air Force base occurs through occupational exposure for personnel involved with fuel and aircraft handling and/or through incidental exposure, primarily through inhalation of ambient fuel vapors. Because JP-8 is less volatile than its predecessor fuel (JP-4), contact with liquid fuel on skin and clothing may result in prolonged exposure. The slowly evaporating JP-8 fuel tends to linger on exposed personnel during their interaction with their previously unexposed colleagues. To begin to assess the relative exposures, we made ambient air measurements and used recently developed methods for collecting exhaled breath in special containers. We then analyzed for certain volatile marker compounds for JP-8, as well as for some aromatic hydrocarbons (especially benzene) that are related to long-term health risks. Ambient samples were collected by using compact, battery-operated, personal whole-air samplers that have recently been developed as commercial products; breath samples were collected using our single-breath canister method that uses 1-L canisters fitted with valves and small disposable breathing tubes. We collected breath samples from various groups of Air Force personnel and found a demonstrable JP-8 exposure for all subjects, ranging from slight elevations as compared to a control cohort to > 100 [mutilpe] the control values. This work suggests that further studies should be performed on specific issues to obtain pertinent exposure data. The data can be applied to assessments of health outcomes and to recommendations for changes in the use of personal protective equipment that optimize risk reduction without undue impact on a mission.
CURRENT LITERATURE
Journal: British Journal of Dermatology (1931)

British Journal of DermatologyVolume 43, Issue 1 p. 42-49 CURRENT LITERATURE First published: January 1931 https://doi.org/10.1111/j.1365-2133.1931.tb09443.xCitations: 1AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Citing Literature Volume43, Issue1January 1931Pages 42-49 RelatedInformation
AN INTRODUCTION TO THE STUDY OF PNEUMONIC FEVER.
Authors: EDWARD F. WELLS
Journal: JAMA (1889)

From the cradle to the grave—from the earliest infancy to the greatest age—man is liable to attacks of pneumonic fever. The newly-born babe, the prattling child, the rollicking boy and winsome girl, the bashful youth and demure maiden, the man in his strength and his mate in her loveliness, the sedate of both sexes as they descend the decline of life, and the aged totterers upon the brink of the grave; all furnish victims to this devouring enemy of mankind. Although no age is exempt, yet the disease is met with much more frequently at some periods of life than at others. During early childhood pneumonic fever finds easy and exceedingly numerous victims. From 5 to 20 years of age the mortality sinks to its lowest level. From 20 to 40 years the proportion is increased somewhat, to be again considerably augmented during the next score of years. Old age
Psychiatric side effects of levodopa in man
Authors: F. K. Goodwin
Journal: JAMA (1971)

Levodopa is the amino acid precursor of the cathecholamines, dopamine and norepinephrine. Along with serotonin, these catecholamines serve as neurotransmitters in areas of the brain related to psychomotor, vegetative, and emotional functions; thus, it is not surprising that the administration of levodopa is associated with mental changes. The documentation and quantification of these mental effects is particularly important because of the potential for increasing our basic understanding of the relationship between brain amines (particularly dopamine) and psychological states both normal and abnormal. When administered to animals, levodopa has been shown to produce a variety of behavioral effects depending to some extent on the dose and species employed; in general, high doses of levodopa produce alerting, motor activation and increased aggressiveness. These studies have recently been the subject of extensive reviews.<sup>1,2</sup> The rationale for the use of levodopa in Parkinsonism is based on evidence that a dopamine deficiency exists in
ROENTGEN-RAY TREATMENT OF CUTANEOUS CANCER
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Transactions of the Medical Society of the State of North Carolina.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Screening for alcoholism
Authors: R. M. Morse
Journal: JAMA (1979)

ALCOHOLISM is one of the most prevalent conditions to confront the primary care physician. In six different hospital studies,<sup>1-3</sup>alcoholism was found in 3.7% to 9.9% of women and in 15.3% to 29% of men. We believe that all general medical patients should be screened for alcoholism and think that this can be done simply and reliably. In general, one must have a high index of suspicion, ask the proper questions, gather the evidence, and understand the condition. We suggest the following approach. <h3>The Right Questions</h3> Two commonly asked questions should be avoided. "How much do you drink?" and "Are you an alcoholic?" usually bring guarded replies and produce little useful information. We think that four simple screening questions can go a long way toward alerting the clinician to alcoholism. "Do you drink?" obviously must begin the screening process. The patient who denies drinking at all should then be
Termination of Dietary Treatment for Phenylketonuria
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BROKEN SLEEP
Authors: G. Rankin
Journal: BMJ (1918)

IN these strenuous times there has been probably no greater interference with the ordinary comfort of humanity than the broken sleep that bas become such a widespread experience since:'the outbreak of war.The disturbance manifests itself in' various ways: some ca'nnot get off, but, once asleep,' rest comfortably till morning'; others go to sleep immediately.'ongettin,g into 'bed, but' wake during the early 'hours.to' toss and tumble a longer or 'shorter time until they fall 'anew, into 'a troubled, and 'uinretreshing slumber,; others, again, hardly sleep at all, if' teir state- ments can be relied upon, though in most instances they at least doze more tlhan they know.To all who suffer thus, in whatever degree, sleep, such' as it is, brings no morning sense of refreshment and reinvigoration, and many are able only too truly to say with Job, " ' When' I lie dow;n.I say,.When shall I arise and the night be
Fetal loss associated with caffeine intake before and during pregnancy
Authors: C. Infante-Rivard
Journal: JAMA (1993)

<h3>Objective.</h3> —To determine if caffeine intake before and during pregnancy was associated with an increased risk for fetal loss. <h3>Design.</h3> —Incidence-density case-control study. <h3>Setting.</h3> —University-affiliated obstetric and pediatric hospital in Montréal, Québec. <h3>Participants.</h3> —A total of 331 women with fetal loss and 993 controls with a normal pregnancy at the same period of pregnancy as the case. <h3>Outcome Measures.</h3> —Crude and adjusted odds ratios (ORs) for fetal loss were estimated using conditional logistic regression. A trend test for increasing caffeine intake was also used. <h3>Results.</h3> —Caffeine intake was divided into quartiles; the baseline for comparison was less than 48 mg per day. The adjusted ORs for fetal loss associated with caffeine intake before pregnancy were 1.29 (95% confidence interval [CI], 0.85 to 1.95) for 48 to 162 mg; 1.37(95% CI, 0.92 to 2.04) for 163 to 321 mg; and 1.85(95% CI, 1.18 to 2.89) for more than 321 mg. The same comparisons were made for caffeine intake during pregnancy, and the respective adjusted ORs were 1.15 (95% CI, 0.82 to 1.63), 1.95 (95% CI, 1.29 to 2.93), and 2.62 (95% CI, 1.38 to 5.01). After controlling for confounding factors, there was a strong association of caffeine intake during pregnancy and fetal loss, compatible with a linear trend on the logistic scale in which ORs increased by a factor of 1.22 (1.10 to 1.34) for each 100 mg of caffeine ingested daily during pregnancy. <h3>Conclusions.</h3> —Caffeine intake before and during pregnancy was associated with an increased risk of fetal loss, supporting the US Food and Drug Administration recommendation to pregnant women, largely based on animal studies, to reduce their caffeine intake. (<i>JAMA</i>. 1993;270:2940-2943)
Nonsurgical closure of large arteriovenous fistulas
Authors: W. R. Castaneda-Zuniga
Journal: JAMA (1976)

We report a nonsurgical closure of large postnephrectomy arteriovenous fistulas in two patients. To our knowledge, this method has not previously been attempted because of the large size of the communication and the risk of pulmonary embolization. However, the development of new embolization techniques makes a nonsurgical approach feasible and safe. (<i>JAMA</i>236:2649-2650, 1976)
Morning Rounds
Authors: George N. Braman
Journal: Annals of Internal Medicine (2010)

Ad Libitum15 June 2010Morning RoundsGeorge N. Braman, MDGeorge N. Braman, MDFrom Bronx, NY 10471-1609.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-152-12-201006150-00028 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail He'd sometimes stop and stare long into spaceIn mid-sentence, as if recalling sounds;“He's lost the thread again,” I'd muse, and graceThe awkward pause the words, resuming rounds.He'd stop at still another patient's sideAnd he'd start an easy conversation(At which he was adept), then gently glideTo the chart, lodged at the nurses' station.“He's still the master,” I'd grant, and concludeNot to let him down, even if the factOf this or that lab value might eludeHis grasp, or his Rx was inexact;His patients glowed with convalescent thanks;We, his entourage, gladly filled the blanks.George N. Braman, MDBronx, NY 10471-1609 Author, Article, and Disclosure InformationAffiliations: From Bronx, NY 10471-1609.Current Author Address: George N. Braman, MD, 5903 Liebig Avenue, Bronx, NY 10471-1609. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 June 2010Volume 152, Issue 12Page: 832KeywordsChartsHand strength ePublished: 15 June 2010 Issue Published: 15 June 2010 Copyright & PermissionsCopyright © 2010 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
ALOPECIA AREATA
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Infectious mononucleosis, autoimmunity, and vasculitis. A case report
Authors: G. S. Hoffman
Journal: JAMA (1979)

EPSTEIN-BARR virus (EBV) has a wide range of effects on its human hosts, the best known being infectious mononucleosis (IM). In most instances, this infection is subclinical. The typical features of fever, sore throat, lymph node enlargement, and hepatitis are present in only 25% to 50% of persons with detectable antibody to EBV. Some patients may chronically harbor EBV in their saliva without apparent ill effects.<sup>1</sup> There is evidence that many of the clinical features of mononucleosis are mediated by the effects of immune complexes on serum and the various tissues in which they are deposited. Mixed cryoglobulins, cold agglutinins, antinuclear antibodies, and rheumatoid factors have been demonstrated in more than half of the cases surveyed for these abnormalities.<sup>2,3</sup>As many as one third have been found to be hypocomplementemic early in the course of the illness.<sup>4</sup>Wands et al<sup>5</sup>have described a patient with IM
Efficacy of bevacizumab plus chemotherapy as first-line treatment of patients with metastatic colorectal cancer: Updated results from a large observational registry in the US (BRiTE)
Authors: M. Kozloff, J. Hainsworth, S. Badarinath, A. Cohn, P. Flynn, R. Steis, W. Dong, S. Suzuki, M. Sugrue, A. Grothey
Journal: Journal of Clinical Oncology (2006)

3537 Background: Bevacizumab (BV) prolongs overall survival and progression-free survival (PFS) when added to standard chemotherapy (CT) in patients with metastatic colorectal cancer (mCRC). BRiTE is a large, community-based observational registry of patients with mCRC receiving BV plus first-line CT. Safety and efficacy information in unselected patients with mCRC are collected. Chemotherapy regimen choice is at the physician’s discretion. Methods: 1968 patients receiving BV plus first-line CT were enrolled at 248 sites in 49 states between Feb 2004 and Jun 2005. Patients are followed for up to 3 years, with data reporting every 3 months (mo) including disease status as assessed by investigator using his/her method of choice. Patients were grouped twice by CT. Cox regression models, adjusted and unadjusted for treatment assignment, were used to identify baseline characteristics (BC) and differential chemotherapy effects on PFS. Results: Cohort demographics were consistent with the NCI Surveillance, Epidemiology, and End Results (SEER) database for mCRC. Median study follow-up was 10 months by Nov 4, 2005. CT regimens included FOLFOX (55.8%), FOLFIRI (14.1%), and IFL (9.7%). Based on observed progression events (n=800) or deaths (n=123), projected median PFS is 11.3 mo (95% CI: 10.4–11.7). Median PFS was comparable in patients treated with CT regimen based on irinotecan (11.3 mo), oxaliplatin (11.4 mo), or neither (10.2 mo) (CT Grouping 1); or 5FU infusion (11.5 mo), 5-FU bolus (9.7 mo), or capecitabine (11.6 mo) (CT Grouping 2). Significant BC in adjusted and unadjusted models are ECOG performance status (PS), primary disease site, and albumin, with no significant difference among CT regimens. Conclusions: This large, community-based registry included a patient population with demographics consistent with the SEER database for mCRC. Preliminary median PFS of 11.3 mo compares favorably to that reported in the pivotal trial. Median PFS appears to be comparable for all CTs when combined with BV. Higher baseline albumin, PS of 0, and primary disease site of rectum were associated with improved outcome. [Table: see text]
Software
Authors: John C. Johnson
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal