tbuckley/cabot-search huggingface dataset:
32nd Annual Meeting and Pre-Conference Programs of the Society for Immunotherapy of Cancer (SITC 2017): Late-Breaking Abstracts
Journal: Journal for ImmunoTherapy of Cancer (2017)

BackgroundImmune activating antibodies are being explored as the next generation of immuno-oncology therapeutics.Activation of CD40 can stimulate both innate and adaptive immune responses against cancer, making it an ideal target for the immune activating approach.CD40 engagement with its ligand CD154 leads to antigen presentation, maturation and expression of co-stimulatory molecules and cytokine production by antigen presenting cells (APC), which are requisite for optimal antigen-specific T-cell activation.Apexigen is developing APX005Ma humanized IgG 1 CD40 agonistic antibody that binds with high affinity to human CD40 (Kd=0.12nM)and carries an S267E mutation in the Fc region.APX005M recognizes a unique epitope that overlaps with the CD40 ligand binding sites and uses FcRγIIb to cluster and activate CD40 thus mimicking CD154 engagement. MethodsIn a "first in human" Phase 1 dose escalating clinical trial, APX005M was administered every 21 days at doses ranging from 0.0001 mg/kg to 1 mg/kg to 30 adult subjects with solid tumors.Primary objectives
Elevated platelet-associated IgG in thrombotic thrombocytopenic purpura
Authors: J. Morrison
Journal: JAMA (1977)

A 41-year-old woman with thrombotic thrombocytopenic purpura (TTP) was treated with prednisone and splenectomy with complete recovery from her illness. Analysis of the patient's platelets for immunoglobulins showed abnormally elevated levels in the range of those seen in thrombocytopenic patients with systemic lupus erythematosus, immune vasculitis, and infectious mononucleosis. This finding is consistent with the concept that the immune system may play a role in the pathogenesis of TTP. (<i>JAMA</i>238:1944-1945, 1977)
Incidence of human immunodeficiency virus seroconversion in US Navy and Marine Corps personnel, 1986 through 1988
Authors: F. C. Garland
Journal: JAMA (1989)

From 1986 through 1988, the US Navy and US Marine Corps administered 1 956 631 enzyme-linked immunosorbent assay screening tests for antibodies to the human immunodeficiency virus to 1 070 511 active-duty enlisted and officer personnel. This study identified all persons who had an initial test with negative results. This population was then followed up and those who later tested positive for human immunodeficiency virus were identified as seroconverters. There were 582 seroconversions identified from a total of 987 479 person-years at risk. The age adjusted seroconversion rate and 95% Poisson confidence intervals for navy personnel was 0.69 per 1000 person-years (95% confidence interval, 0.63 to 0.76). Age-adjusted rates in men were 5.0 times those of women. Age-adjusted rates in blacks were 3.7 times those of whites. The age-adjusted seroconversion rate in Marine Corps personnel was 0.28 per 1000 person-years (95% confidence interval, 0.22 to 0.36). Similar demographic patterns were present in the Marine Corps and the US Navy. This study is one of the first reports of incidence of human immunodeficiency virus seroconversion by demographic characteristics in a large, young, and apparently healthy population. (<i>JAMA</i>. 1989;262:3161-3165)
State Boards of Registration
Journal: JAMA (1910)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abrogation of Donor T Cell IL-21 Signaling Leads to Tissue-Specific Modulation of Immunity and Separation of Gvhd From GVL
Authors: Alan M. Hanash, Lucy W. Kappel, Nury L. Yim, Rebecca A. Nejat, Gabrielle L. Goldberg, Odette M. Smith, Uttam K. Rao, Lindsay Dykstra, Il-Kang Na, Amanda M. Holland, Chen Liu, George F. Murphy, Warren J Leonard, Glenn Heller, Marcel R.M. van den Brink
Journal: Blood (2010)
Judaism and Science, with Other Addresses and Papers from the Writings of Solomon Solis-Cohen and with a Bibliography of the Writings and Addresses of Solomon Solis-Cohen
Journal: JAMA (1941)

This book, which contains the writings of Solomon Solis-Cohen, was published by friends of the author in honor of his eighty second birthday. The volume is limited to his nonmedical writings. However, some of the papers bear some relation to medicine, such as "Washington's Death and the Doctors," "Can Our Procedures for the Judicial Determination of the Cause of Death be Bettered?" "The Proper Scope of Scientific (So-Called Expert) Testimony in Trials Involving Pharmacological Questions" and "Tuberculosis: A Social Question." In addition there are papers of general interest, such as "Henry George" and "Franklin, the Philadelphian." All the other papers deal with Jewish life, particularly with Jewish history. A bibliography of all of Solis-Cohen's writings, nonmedical as well as medical, is included in the volume. There is also a list of books that have been dedicated to him by various authors. The book shows the many and varied interests of
Common tests of thyroid function in serum
Authors: H. A. Selenkow
Journal: JAMA (1967)

Correct diagnosis of most common disorders of thyroid function can usually be achieved by a thorough clinical evaluation and confirmed by a few carefully selected laboratory procedures. There are now available a number of relatively specific and accurate tests for measurement of thyroid hormone synthesis, secretion, transport, and metabolic action. Unfortunately, none alone is fully diagnostic of any single thyroid disorder and all can be misleading as a result of a wide variety of factors which influence their pathophysiologic significance. This presentation will be limited to a brief discussion of a few serum measurements of thyroid function of clinical importance to medical practice. The reader interested in more detailed considerations of this extensive subject is referred to recent reviews.<sup>1,2</sup> The two principal thyroid hormones, thyroxine (T<sub>4</sub>) and triiodothyronine (T<sub>3</sub>) are normally secreted into the circulation under the control of pituitary thyrotropin (TSH). They are transported through the
Access to Health Care for the Uninsured: The American Academy of Family Physicians-Reply
Authors: Glen F. Aukerman
Journal: JAMA (1991)

<h3>In Reply.</h3> —I appreciate Dr Brody's recognition of the continuing efforts of the AAFP to address the broad policy concerns of providing access to care for all Americans. As an academy, we are wrestling with the difficult (for physician organizations) issues of cost containment, delivery system reform, and primary care physician supply as components of a health care access reform proposal, and we contemplate development of a more comprehensive policy statement in the next year. Ms Zanca's letter poignantly illustrates the plight of Medicaid patients today—lack of access to physicians. The AAFP recognizes that expanding access through Medicaid must include substantial revision of the Medicaid program (and probably a new identity as well) to overcome the real obstacles she and her son so unfortunately experienced.
Anicteric Hepatitis
Authors: William H. J. Summerskill
Journal: JAMA (1962)

THE ANICTERIC FORM of hepatitis deserves greater attention as an individual entity for several reasons. Considerable evidence suggests that it is as common as viral hepatitis with jaundice, yet the diagnosis is made much less frequently, thus contributing to spread of the disease. In addition, anicteric hepatitis is a cause of obscure and occasionally serious illness and has an uncertain relationship to the later development of cirrhosis Many aspects of anicteric hepatitis are similar to those associated with hepatitis complicated by jaundice. Studies from transmission experiments or epidemics indicate that both diseases may result from the same virus or viruses and that the incubation periods are similar. Anicteric hepatitis implies the absence of clinical jaundice, and this is the most practical definition of the disorder, but many prefer to restrict the diagnosis to patients in whom there is no abnormality of the serum bilirubin concentration. In either instance, at some
FRIDAY 25TH MARCH
Journal: Gut (1994)

Background: Distension of the human jejunum provokes the peristaltic reflex characterised by proximal excitation and distal inhibition mediated by intrinsic nervous pathways.Aim: To investigate enteric neural function of transposed jejunal loops following gastrectomy in patients with and without symptoms of loop dysfunction of stasis.Patients: Ten patients were studied (mean age: 63.1, sex: M;5, F;5), following partial gastrectomy in 5, total gastrectomy with Roux-en-Y in 3, and proximal gastrectomy and interposition of a jejunal loop in 2. Four patients were asymptomatic (AS) and six had postoperative symptoms (S).Methods: After an overnight fast a multilumen manometric catheter with a 4cm silicone balloon was placed in the transposed jejunal loop, and stepwise balloon distension in 10ml increments was performed.Data Analysis: Manometric changes were recorded 2 and 4cm proximal and distal to the balloon and assessed by measuring the area under the curve (AUC) and the peristaltic reflex assessed as ratios of proximal vs distal response.Perception at each volume was scored.Result: The ratios of AUC in AS group were higher than the S group at each increment reached significance at 10ml distension (AS vs S; 3.32±1.50vs 0.84±0.20 (p<0.05)).The sensory thresholds in AS group were significantly higher than those in S group (AS vs S; 46.5+2.4 vs 30±4.8 (p<0.05)) and the sum of the perception scores in AS group were significantly lower than those in S group (AS vs S; 1.25 ±0.5 vs 7.8±2.2 (p<0.05)).Conclusion: In the S group an abnormal peristaltic reflex and the lower sensory threshold in transposed jejunal loop correlates with the stasis symptoms.Both abnormalities may relate to the poor tolerance of food.
Fellowships, Grant, Awards
Journal: JNCI Journal of the National Cancer Institute (1993)

Fellowships, Grant, Awards Get access JNCI: Journal of the National Cancer Institute, Volume 85, Issue 18, 15 September 1993, Pages 1530–1531, https://doi.org/10.1093/jnci/85.18.1530 Published: 15 September 1993
Artificial heart still holds promise, DeVries says; program continues
Authors: H. Cole
Journal: JAMA (1985)

Three patients—two in the United States and one in Sweden—are now living with Jarvik-7 total artificial hearts, and the number of patients sustained with this device is likely to increase in the coming months despite the death of the latest patient. According to William C. DeVries, MD, attending surgeon, Humana Heart Institute International, Humana Hospital-Audubon, Louisville, centers in at least four other states are in the process of seeking Institutional Review Board and Food and Drug Administration (FDA) approval to begin clinical investigations with the artificial heart. DeVries, who is the only surgeon authorized by the FDA to implant the Jarvik-7 heart, has permission to implant the heart in seven patients before reapplying for another go-ahead from the FDA. In an interview on the eve of performing his fourth implant, DeVries discussed the future of the artificial heart program and his experience thus far with the heart recipients: "I don't
Ulcerative colitis
Authors: A. C. Ford, P. Moayyedi, S. B. Hanauer
Journal: BMJ (2013)

<h3>Objective</h3> The aim of this study was to assess the impact of the evolving role of the addition of chemotherapy to postoperative radiotherapy on oncological outcomes and toxicity in patients with early-stage cervical cancer after radical hysterectomy. <h3>Methods</h3> Retrospective cohort study of patients with stage IB1–IIB FIGO 2009 cervical cancer treated from November 1999 to May 2015 by primary surgery and radiotherapy (46–50.4 Gy in 1.8–2.0 Gy fractions) with or without concurrent cisplatin (40 mg/m<sup>2</sup>, 5–6 weekly cycles) with or without a brachytherapy boost. Chemotherapy was allocated depending on the risk factors for recurrence. Incidences of all outcomes were calculated using Kaplan–Meier’s methodology and compared by log-rank tests. Risk factors for recurrence and survival were identified using Cox’s proportional hazards models. <h3>Results</h3> A total of 154 patients were included, median follow-up was 9.6 years (IQR: 6.1–12.8). Five-year pelvic recurrence-free survival was 75.3%; 74.7% in patients with high-risk factors treated with radiotherapy; and 77.3% in those treated with chemoradiation (P=0.43). Distant metastasis-free survival at 5 years was 63.4%; 63.6% in high-risk patients after radiotherapy; and 57.1% after chemoradiation (P=0.36). Five-year overall survival was 63.9%: 66.8% and 51.6% after radiotherapy and after chemoradiation in patients with high-risk factors (P=0.37), respectively. Large tumor size was a risk factor for vaginal and pelvic recurrence, ≥2 involved lymph nodes was a significant risk factor for para-aortic recurrence and death. Mild treatment-related late toxicity was observed in 53.9% of the patients. Five-year severe (grade 3–5) late rectal, bladder, bowel, and vaginal toxicities were, respectively, 1.3%, 0%, 3.4%, and 0.9%. Any late severe toxicity was observed in 5.5% of patients treated with radiotherapy and in 15.3% of those treated with chemoradiation (P=0.07). <h3>Conclusion</h3> Postoperative (chemo)radiation for early-stage cervical cancer patients with risk factors for recurrence yields adequate pelvic tumor control, but overall survival is limited due to distant metastasis.
Wading through Questions about Aquatic Toxins
Authors: Carla Burgess
Journal: Environmental Health Perspectives (1997)

The toxic dinoflagellate Pfiesteria piscicida may have captured the spotlight along the coast of North Carolina and Maryland, but this nefarious creature is not the only one of its kind.Worldwide, toxic aquatic organisms responsible for such maladies as red tides, cholera outbreaks, and seafood poisoning have surfaced with increasing frequency and geographic distribution during the past 20 years.Such surfacings have brought moreAnabeena circinalis questions than answers, ques-
OPIUM POISONING.
Authors: J. R. Barnett
Journal: JAMA (1883)

<h3>Editor Journal of the American Medical Association:</h3> The treatment of opium poisoning by atropine has been too long and successfully practiced to need the support of any new clinical facts, still there are modifications of the treatment which may merit notice, inasmuch as it does not always happen in emergencies of this class, which the physician is called upon to meet, that he finds a salt of atropia accessible. In such cases he is not without resources if his pocket medicine case is ordinarily well equipped. A few days ago a two-days-old baby was given one-fourth grain of morphine by mistake. I saw it nine hours later, when at first sight, it seemed to be dead, as the friends believed it to be. Deeply cyanotic, it showed no sign of respiration, and the pulse at the wrist was absent, as indeed it remained, except at short intervals, for many hours.
Landmark perspective: Dermatitis herpetiformis. A commentary
Authors: J. B. Kalis
Journal: JAMA (1983)

The early 19th century marked the birth of dermatology as a specialty in Europe. Postgraduate training in dermatology was available only in the European capitals. When Louis Duhring returned to his native Philadelphia after two years of specialty training in London, Paris, and Vienna, he established a private practice and a public dispensary devoted to the diagnosis and treatment of skin disorders. Duhring's keen clinical sense, pragmatic approach, clarity of prose, and thorough knowledge of the literature soon gained him local recognition. In 1873, he was appointed as a lecturer on skin disorders at the University of Pennsylvania, Philadelphia. In 1875, at the age of 35 years, he was appointed the first professor of dermatology at the University of Pennsylvania, a post he held for 35 years. His excellent textbooks, widely read here and in Europe, and his establishment of dermatitis herpetiformis (DH) as a distinct disease entity soon led
Detection of hepatitis C viral RNA by the polymerase chain reaction Weiner AJ, Kuo G, Bradley DW, Bonino F, Saracco G, Lee C, Rosenblatt J, et al. Detection of hepatitis C viral sequences in non-A, non-B hepatitis. Lancet 1990;335:1–3 Garson JA, Tedder RS, Briggs M, Tuke P, Glazebrook JA, Trute A, Parker D, et al. Detection of hepatitis C viral sequences in blood donations by “nested polymerase chain reaction” and prediction of infectivity. Lancet 1990;335:1419–1422
Authors: M Lucey
Journal: Hepatology (1991)
Surgery, Gynecology and Obstetrics, Chicago
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Neonatal Hyperbilirubinemia
Authors: Phyllis A. Dennery, Daniel S. Seidman, David K. Stevenson
Journal: New England Journal of Medicine (2001)

Icterus neonatorum, or neonatal jaundice, has long been recognized.1 The term "kernicterus" was introduced in the early 1900s to refer to the yellow staining of the basal ganglia observed in infants who died with severe jaundice.2 From the 1950s through the 1970s, because of a high incidence of Rh hemolytic disease and kernicterus, pediatricians were aggressive in treating jaundice.3 However, several factors have changed the management of jaundice. Studies in the 1980s and 1990s suggested that kernicterus from jaundice was rare and that too many infants were being treated unnecessarily.47 Also, newborn infants were being discharged from the hospital . . .
Tobacco Smoke Allergy
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Masthead: (Adv. Healthcare Mater. 15/2018)
Journal: Advanced Healthcare Materials (2018)

Citizenship: Wiley's Corporate Citizenship initiative seeks to address the environmental, social, economic, and ethical challenges faced in our business and which are important to our diverse stakeholder groups.Since launching the initiative, we have focused on sharing our content with those in need, enhancing community philanthropy, reducing our carbon impact, creating global guidelines and best practices for paper use, establishing a vendor code of ethics, and engaging our colleagues and other stakeholders in our efforts.
The Science of Radiology
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The use of autologous blood. The National Blood Resource Education Program Expert Panel
Journal: JAMA (1990)

The risk of transmitting disease through blood transfusions continues to fall as additional blood donor screening and testing measures are implemented. Nevertheless, when a blood transfusion is needed during the perioperative period, autologous blood is the safest option for eligible patients. Three methods for obtaining autologous blood to use during or after a planned surgical procedure are preoperative autologous blood donation, perioperative blood salvage, and acute normovolemic hemodilution. These techniques can be used alone or in combination to decrease or eliminate a patient's exposure to homologous blood. However, because all transfusions carry some health risk and blood administration costs, autologous blood should not be collected or reinfused indiscriminately. Autologous blood services should be used for eligible patients who are likely to require a transfusion but should not be employed for minor procedures in which transfusion is unlikely.