tbuckley/cabot-search huggingface dataset:
Diphyllobothriasis
Authors: W. R. Barclay
Journal: JAMA (1981)

A report of diphyllobothriasis (fish tapeworm disease) in<i>Morbidity and Mortality Weekly Report</i>(<i>MMWR</i>) (July 17, 1981) serves as a reminder that medical practice often presents physicians with unusual rather than simple, familiar diagnostic challenges. Large numbers of Americans travel abroad each year, and some of these return to the United States suffering from illnesses not normally encountered here. Others who stay at home may partake of foreign dishes that offer infectious agents as well as gustatory delight. The key to recognizing rarely encountered viral, bacterial, and parasitic infections is a carefully taken history plus knowledge of the epidemiology of these infections. The report in<i>MMWR</i>describes an outbreak of diphyllobothriasis in a group of physicians who attended a party at which sushi (made from fresh tuna and red snapper purchased in California and fresh salmon from Alaska) was served. Stool examinations confirmed the diagnosis in four of the group.
THE FUNCTION OF THE CORPUS STRIATUM
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE PIT SNAKE
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Large-dose bleomycin therapy and pulmonary toxicity. A possible role of prior radiotherapy
Authors: M. L. Samuels
Journal: JAMA (1976)

Bleomycin sulfate pulmonary toxicity was encountered in nine of 101 patients receiving high-dose therapy for widespread testicular cancer. The pulmonary presentation was separable into two categories: (1) an early or minimal form with dyspnea on exertion, minimal roentgenographic findings, and normal arterial partial pressure of oxygen at rest and (2) a severe form, with prominent roentgenographic findings and hypoxemia at rest. All five patients with the severe form died, while the remaining four patients with the minimal presentation recovered. Prior thoracic radiotherapy appeared to predispose to bleomycin pulmonary toxicity, as this complication developed in five of 12 patients receiving prior chest radiotherapy vs four of 89 not receiving radiotherapy (<i>P</i>&lt;.001). The fatality rate of 5% with high-dose bleomycin therapy is acceptable in view of the 75% response rate and substantially improved survival achieved with bleomycin combination chemotherapy in metastatic testicular cancer. (<i>JAMA</i>235:1117-1120, 1976)
Cellular and Molecular Architecture of Hematopoietic Stem Cells and Progenitors in Genetic Models of Bone Marrow Failure
Authors: Stephanie C. Heidemann, Brian Bursic, Sasan Zandi, Hongbing Li, Robert J Klaassen, Sharon Abish, Meera Rayar, Vicky R. Breakey, Houtan Moshiri, Santhosh Dhanraj, Richard de Borja, Adam Shlien, John E. Dick, Yigal Dror, Sagi Abelson
Journal: Blood (2019)
"THE NECESSITY OF CLEAR THINKING IN MILK MODIFICATION"
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Symposium on Occupational Radiation Exposure In Nuclear Fuel Cycle Facilities
Journal: JNCI Journal of the National Cancer Institute (1979)

Journal Article Symposium on Occupational Radiation Exposure In Nuclear Fuel Cycle Facilities Get access JNCI: Journal of the National Cancer Institute, Volume 62, Issue 1, January 1979, Page 213, https://doi.org/10.1093/jnci/62.1.213e Published: 01 January 1979
Viruses and human cancers: challenges for preventive strategies.
Authors: G de The
Journal: Environmental Health Perspectives (1995)

Virus-associated human cancers provide unique opportunities for preventive strategies. The role of human papilloma viruses (HPV 16 and 18), hepatitis B virus (HBV), Epstein-Barr herpes virus (EBV), and retroviruses (human immunodeficiency virus [HIV] and human T-cell leukemia/lymphoma virus [HTLV]) in the development of common carcinomas and lymphomas represents a major cancer threat, particularly among individuals residing in developing countries, which account for 80% of the world's population. Even though these viruses are not the sole etiological agents of these cancers (as would be the case for infectious diseases), different approaches can be implemented to significantly decrease the incidence of virus-associated malignancies. The first approach is vaccination, which is available for HBV and possibly soon for EBV. The long delay between primary viral infection and development of associated tumors as well as the cost involved with administering vaccinations detracts from the feasibility of such an approach within developing countries. The second approach is to increase efforts to detect pre-cancerous lesions or early tumors using immunovirological means. This would allow early diagnosis and better treatment. The third strategy is linked to the existence of disease susceptibility genes, and suggests that counseling be provided for individuals carrying these genes to encourage them to modify their lifestyles and other conditions associated with increased cancer risks (predictive oncology). Specific recommendations include: a) increase international studies that explore the causes of the large variations in prevalence of common cancers throughout the world; b) conduct interdisciplinary studies involving laboratory investigation and social sciences, which may suggest hypotheses that may then be tested experimentally; and c) promote more preventive and health enhancement strategies in addition to curative and replacement therapies.
Core Quality and Outcome Measures for Pediatric Health—Reply
Authors: William Gardner, Kelly J. Kelleher
Journal: JAMA Pediatrics (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
The Costs of Preventing Kidney Failure in People with Diabetes
Journal: Annals of Internal Medicine (1999)

Summaries for Patients2 November 1999The Costs of Preventing Kidney Failure in People with DiabetesSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-131-9-199911020-00036 SectionsAboutFull Text ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Kidney failure is a late complication of diabetes. Medicines called angiotensin-converting enzyme (ACE) inhibitors delay kidney failure in persons with diabetes. There are two ways to detect early kidney damage: testing urine for a moderate amount of protein (proteinuria) or for a small amount of protein (microalbuminuria). (Proteinuria is easier to test for but detects kidney damage later). Experts therefore recommend testing diabetic patients yearly and starting therapy with ACE inhibitors as soon as microalbuminuria develops. However, many patients with diabetes who might benefit from ACE inhibitors do ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “The Cost-Effectiveness of Treating All Patients with Type 2 Diabetes with Angiotensin-Converting Enzyme Inhibitors.” It is in the 2 November 1999 issue of Annals of Internal Medicine (volume 131, pages 660-667). The authors are L. Golan, J.D. Birkmeyer, and H.G. Welch.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe Cost-Effectiveness of Treating All Patients with Type 2 Diabetes with Angiotensin-Converting Enzyme Inhibitors Lubor Golan , John D. Birkmeyer , and H. Gilbert Welch Metrics 2 November 1999Volume 131, Issue 9Page: 660KeywordsACE inhibitor therapyACE inhibitorsHealth careKidneysMicroalbuminuriaProteinsProteinuriaQuality adjusted life yearsQuality of lifeRenal failure ePublished: 15 August 2000 Issue Published: 2 November 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.Loading ...
A NEW INSTRUMENT FOR LIGATING BLEEDING BLOOD VESSELS AFTER THE REMOVAL OF TONSILS
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 370: The PI3K inhibitor, taselisib (GDC-0032), has enhanced potency in PIK3CA mutant models through a unique mechanism of action
Authors: Kyle A. Edgar, Kyung Song, Stephen Schmidt, Don Kirkpatrick, Lilian Phu, Michelle Nannini, Rebecca Hong, Eric Cheng, Amy Young, Deepak Sampath, Lori S. Friedman
Journal: Cancer Research (2016)

Abstract Alterations of the phosphoinositide-3 kinase (PI3K)/Akt signaling pathway occur broadly in cancer via multiple mechanisms including mutational activation of the PIK3CA gene. The dysregulation of this pathway has been implicated in tumor cell growth and survival, thus PI3K is a promising therapeutic target with multiple inhibitors in clinical trials. The mechanism of action of taselisib (GDC-0032), a novel, oral, selective inhibitor of p110alpha sparing inhibition of p110beta, is investigated in these preclinical studies. Taselisib demonstrates greater potency in cancer cell lines harboring activating mutations in PIK3CA vs. wild-type lines, and induces regressions at tolerated doses in both PIK3CA mutant xenograft and patient-derived xenograft (PDX) models. When comparing taselisib to other clinical-stage PI3K inhibitors at Maximum Tolerated Dose (MTD) in vivo, taselisib confers greater activity in PIK3CA mutant models, which may indicate a larger therapeutic index. Unlike other PI3K inhibitors, taselisib has a gain of potency in PI3K alpha mutant SW48 isogenic cells compared to wildtype SW48 parental cells. Pathway inhibition and increased apoptosis are associated with the enhanced activity observed in PI3K alpha mutant cells. Other clinical PI3K inhibitors, including PI3K alpha selective and pan-PI3K inhibitors, do not have improved potency in PI3K alpha mutant cells due to their inability to maintain pathway suppression after alleviation of negative feedback. The unique mechanism of action of taselisib is most notable when comparing signaling suppression at 24 hours vs. 1 hour of drug exposure. In mutant cells, Taselisib displays greater pathway suppression at 24 hours and is more effective at maintaining pathway suppression upon re-activation of growth factor RTK signaling. This mechanism is specific to PIK3CA mutant cells and not observed in wildtype cells. Ongoing studies to further elucidate this mechanism of action will be presented. Citation Format: Kyle A. Edgar, Kyung Song, Stephen Schmidt, Don Kirkpatrick, Lilian Phu, Michelle Nannini, Rebecca Hong, Eric Cheng, Amy Young, Deepak Sampath, Lori S. Friedman. The PI3K inhibitor, taselisib (GDC-0032), has enhanced potency in PIK3CA mutant models through a unique mechanism of action. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 370.
Major Issues in Miner Health
Authors: Stephanie Joyce
Journal: Environmental Health Perspectives (1998)

As recently as the last few decades, thousands of miners died in explosions, roof collapses, fires, and floods each year, and lung disease caused by inhaling mineral dusts was ubiquitous. Miners worked virtually unprotected, and were often treated as expendable bodies fulfilling critical roles in this important industry, which in the United States comprises about 5% of the gross domestic product.
Rambling Notes of a Roving Doctor.
Authors: W. S. Caldwell
Journal: JAMA (1900)

Paris, August, 1900. <h3>PARIS EXPOSITION.</h3><h3>To the Editor:</h3> —I have a clipping from an American newspaper regarding the Paris Exposition, in which the writer claims that in the great art gallery, where the different nations have their pictures on exhibition, the United States eclipses them all. Before I read this I had visited and studied with some care this collection, and I had put the United States in about the ninth place, as compared with the works of other countries. We have, it is true, a few good pictures, especially good portraits, but the collection as a whole does not do us credit as a nation possessing a high order of artistic skill. While, I believe, it was understood that France was to have 45 per cent, of the space alloted to exhibitors, she has managed the matter so much to her advantage that she has appropriated at least three-quarters
Acute non-A, non-B hepatitis with serum sickness-like syndrome and aplastic anemia
Authors: R. P. Perrillo
Journal: JAMA (1981)

We treated a patient in whom acute non-A, non-B hepatitis was complicated by a serum sickness-like syndrome (rash, arthralgias). Serum from this patient demonstrated a fall in C3, C4, and total hemolytic complement levels during the syndrome, in association with circulating IgM immune complexes. Fatal aplastic anemia developed later in the patient. This case illustrates that non-A, non-B hepatitis may be complicated by immune complex features that have previously been emphasized to occur with acute hepatitis B. Additional evidence supporting the occurrence of this clinical picture in non-B forms of viral hepatitis is presented. (<i>JAMA</i>1981;245:494-496)
Correction: Alpha-chain disease diagnosed by rectal biopsy
Authors: Nigel Bullock, J Parrilla, L Ortega, L Pena, R De Salamanca, G Elder
Journal: BMJ (1980)

and trismus.As an acute presentation is unexpected therefore, clinical assessment in this case was difficult.A diagnosis of salivary duct calculi should always be considered in children when there is submandibular swelling and the appearances are uncharacteristic of suppurating cervical nodes.In this way inappropriate exploration of the cervical swelling will be avoided.
3C: Pathological aspects of H. pylori infections
Authors: T Havard, P Sarsfield, H Steer, Hosp Southampton General, Rd Tremona, R Suriani, E Cerutti, D Mazzucco, C Pallante, M Vajo, M Ravizza, D Dusio, G Cera, E Cardesi, Evangelico Rivoli
Journal: Gut (1996)

Using microwave antigen retrieval and an immunohistochemical technique we examined the density of Retinoblastoma gene protein (RBp) expression and the proliferative state of gastric epithelium.The tissue samples were retrieved from the non-malignant resection margins of 24 gastrectomy specimens from patients with gastric adenocarcinoma.The staining of the antibodies was quantified by cell counts and the severity of the inflammation in the specimens graded by the number of lymphoid follicles per mm of mucosa examined.The epithelial cells of the proliferative compartment, around the neck of the crypts produced the densest staining of both antibodies.Little or no uptake of either antibody in the mature differentiated epithelial cells in the deep glandular or superficial lumenal areas.There were two distinct levels of RBp expression.One group had a high level of RBp staining and included all of the cases with severe inflammation.The cases with little or no inflammation had a lower level of RBp in the epithelium.A similar relationship was found between the proliferative state of the epithelium and the RBp expression.The cell counts of the two antibod- ies (MiB-l and RBp) in the proliferative compartment had a correlation coeficient 0.78 (95% con.lim.0.53-0.88).The role of mutational loss of function of RBp in the sequence of gastric tumour development and progression is as yet undefined.Our data provides strong evidence that in the hyperproliferative state associated with chronic gastritis RBp plays a vital role in the control of cell proliferation.
Alterations in Steroidogenesis in Alligators (Alligator mississippiensis) Exposed Naturally and Experimentally to Environmental Contaminants
Authors: D. Andrew Crain, Louis J. Guillette, Andrew A. Rooney, Daniel B. Pickford
Journal: Environmental Health Perspectives (1997)

Many environmental contaminants alter the reproduction of animals by altering the development and function of the endocrine system. The ability of environmental contaminants to alter the endocrine system of alligators was studied both in a descriptive study in which juvenile alligators from a historically contaminated lake were compared to animals from a control lake and in an experimental study in which hatchling control alligators were exposed in ovo to several endocrine-disrupting standards and two modern-use herbicides. Endocrine status was assessed by examining plasma hormone concentrations, gonadal-adrenal mesonephros (GAM) aromatase activity, and gonadal histopathology. In the descriptive study, juvenile alligators from the contaminated lake had significantly lower plasma testosterone concentrations (29.2 pg/ml compared to 51.3 pg/ml), whereas plasma 17 beta-estradiol concentrations did not vary when compared to controls. GAM aromatase activity was significantly decreased n the alligators from the contaminated lake (7.6 pmol/g/hr compared to 11.4 pmol/g/hr). In the experimental study, the endocrine-disrupting standards had the expected effects. 17 beta-Estradiol and tamoxifen caused sex reversal from male to female, with a corresponding increase in aromatase activity. Vinclozolin had no apparent effect on male or female alligators. Among the herbicides tested, atrazine induced GAM aromatase activity in male hatchling alligators that was neither characteristic of males nor females, although testicular differentiation was not altered. Exposure to 2,4-dichlorophenoxyacetic acid had no effect on the endocrine parameters that were measured. Together, these studies show that exposure to some environmental chemicals (such as atrazine) can alter steroidogenesis in alligators, but the endocrine alterations previously noted for Lake Apopka, Florida, alligators can not be fully explained by this mechanism.