tbuckley/cabot-search huggingface dataset:
AUTOGENOUS BONE TRANSPLANTATION
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ticlopidine-induced aplastic anemia: Development of chromosomal abnormalities and response to immunosuppressive therapy
Authors: Vinod A. Pullarkat, Hyan Rho, Joyce L. Murata-Collins, Howard A. Liebman
Journal: American Journal of Hematology (2000)

Severe aplastic anemia is a well-recognized complication of ticlopidine therapy that carries a high mortality. Therapy with colony-stimulating factors or corticosteroids has been largely ineffective in this disorder. We report a case of ticlopidine-induced aplastic anemia that was successfully treated with cyclosporine and high-dose dexamethasone. The patient rapidly responded to immunosuppressive therapy and had a normal hemogram after cessation of immunosuppression. On long-term follow-up, the patient developed a progressive macrocytic anemia. Repeat bone marrow evaluation demonstrated myelodysplasia with erythroid hypoplasia. An associated chromosomal abnormality consisting of a t(3;16) (q21; p13.3) translocation was detected. This is the first report of a chromosomal abnormality associated with ticlopidine induced marrow aplastic anemia. Am. J. Hematol. 63:141–144, 2000. © 2000 Wiley-Liss, Inc.
Reporting on Cancer Research
Authors: Michael B. Shimkin M.D.
Journal: CA A Cancer Journal for Clinicians (1974)

Jacobi.Kokich and Emil FreiHI report on a phase 2 study of concurrent methotrexate and bleomycin chemotherapy in 30 patients with metastatic neoplasms, primarily squamous cell carcinomas.Ten of 19 patients that could be evaluated had objective tumor regression with a median durationof fourmonths.Bleomycin-induced pulmonarytoxicity oc curred in four patients, one of whom died.The authors hoped that other modifications of the regimen may improve thera peutic effectiveness.(September) Many of the new combinations and regimens of drugs being clinically investigated are based on increasingly so phisticated cellular metabolic considerations.For example, Potu N. Rao et al. (M.D. Anderson Hospital, Houston, Texas) explored administration sequences of two drugs in vitro.Ara-C, an analog of cytidine that selectively stops DNA synthesis by blocking polymerase activity, and B-2'deoxythioguanosine (B-TGdR) were tested on the cloning ability of HeLa and Chinese hamster ovary cells.The maxi mum kill was produced by ara-C followed by B-TGdR, with synergism being due to the synchronizing effect of ara-C.The results suggest clinical trial of short pulse infusions of ara-C at a low dose, followed by B-TGdR.(October) The expanding interest in using in vitro models for extrapolations to clinical trials is also evident in the work of George M. Hahn et al. (Stanford University School of Medi cine, Stanford, California), who determined the effects of BCNU and bleomycin on cycling and non-cycling cells (September).Xenophon Yataganas et al. (Memorial S loan Kettering Cancer Center, New York, New York) analyzed cell kinetics on human lymphoid cells at various concentra tions and durations of exposure to ara-C.(October) Another approach to quantitative control in chemotherapy is the work of Merrill J. Egorin et al. (NCI Cancer Research Center, Baltimore, Maryland) who determined adriamycin and daunorubicin in hamster tissues by fluorescent micros copy.The characteristic orange-red fluorescence was local ized primarily in cell nuclei.An application to frozen tumor tissue in patients treated by these agents could be useful.(September) Francesco Bresciani et al. (University of Naples, Italy) studied cell kinetics and growth of squamous cell carcinomas of man, by means of radioactive thymidine before and after treatment.The data show the complexity of this problem of population kinetics.The faster growth of carcinoma was due both to higher cell birth rate and smaller cell loss.The higher birth rate was primarily due to a larger fraction of cells being involved in division, rather than a faster rate of division as measured by intermitotic time.These observations also will find application in selecting chemotherapeutic regimens.(September)
Trigeminal Neuralgia
Authors: Giorgio Cruccu, Giulia Di Stefano, Andrea Truini
Journal: New England Journal of Medicine (2020)

Trigeminal neuralgia is manifested by severe, paroxysmal facial pain. The classical type involves compression of the trigeminal nerve root. Sodium-channel blockers are the first-choice treatment; if they are unsuccessful, vascular decompression or ablative procedures may be used.
Income, health, and social welfare policies
Authors: None The Lancet Public Health
Journal: The Lancet Public Health (2020)

Socioeconomic status and income are determinants of health, linked to life expectancy, quality of life, and disease risk, with many diseases more prevalent in people from low socioeconomic status. Individuals from socioeconomically deprived backgrounds are also more susceptible to the effects of unhealthy lifestyles. Unequal distribution of income and health inequality are closely linked. This issue of The Lancet Public Health features research that explores further the interconnection between income and health, and the health consequences of government policies that shape personal income.
Cephaloridine and Impaired Renal Function
Authors: R. W. POSTELTHWAIT
Journal: JAMA (1971)

<h3>To the Editor.—</h3> It was not our purpose to imply that cephaloridine (a drug that is 80% excreted by the kidney) could not be nephrotoxic in high doses, but rather to put this possible nephrotoxicity in proper perspective. Under conditions with adequate glomerular filtration rate and recommended doses of cephaloridine, additional impairment of renal function did not occur in our patients; most improved or remained unchanged. Although randomized studies are desirable from a scientific standpoint, they are frequently not practical. Bennett and Porter's patient who developed acute tubular necrosis after 18 gm of cephaloridine over a three-day period should not be given cephaloridine or any other medication which is normally excreted by the kidney, for extremely high serum levels will occur. However, to imply that this small amount of cephaloridine caused the acute tubular necrosis ignores the medical obligations to recognize, identify, and treat other more likely causes of acute
THE TRIAD IN SPACE
Authors: J. H. T.
Journal: JAMA (1960)

IT IS proverbial that man must crawl before he walks. Similarly, man has learned to survive in the inner atmosphere before preparing to enter outer space. The achievements of Sir Edmund Hillary and Tenzing in 1953, which were duplicated recently by the Chinese Communists, demonstrated that acclimatization and supplementary oxygen make it possible for man to climb without other auxiliary help to an altitude of 29,002 feet. (The Chinese Reds have calculated the height of Mt. Everest to be 29,133 ft.) Preceding this "first" by two members of the free world, years of physiological investigation yielded invaluable information on the phenomenon of acclimatization to altitudes and oxygen pressures less critical than those experienced on this Himalayan peak. Studies on acclimatization to outer space are the deep concern of the astronaut-physiologist at the present time. These and other researches are detailed in a volume entitled<i>Physics and Medicine of the Atmosphere</i>
Miscellany.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Analysis and Report on Original Documentary Evidence Concerning the Use of Opium in India: [Furnished to the "British Medical Journal" by upwards of 100 Indian Medical Officers.]
Journal: BMJ (1894)

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Authors: Chia-Ming Chu
Journal: Hepatology (2008)

As described in the section of Patients and Methods, all study patients did not receive antiviral or immunomodulatory therapy before entry and during follow-up, so all 24 patients with reactivation of hepatitis B had "spontaneous" HBsAg seroclearance 3–20 years after the onset of hepatitis B. The number of patients with age at entry of 60–69 years and ≥70 years were very small, so they were grouped together with those with age at entry of 50–59 years as patients with age at entry ≥50 years. Many authors have divided the natural course of perinatally acquired chronic hepatitis B virus infection into four phases: immune tolerance, immune clearance, inactive carrier state, and reactivation of hepatitis B. However, as seen in the current study, only 16% (314/1965) of anti-HBe–positive carriers had reactivation of hepatitis B during a long-term follow-up of more than 20 years. The cumulative probabilities of reactivation of hepatitis B in this series were 9.7%, 17.1%, 19.6%, and 21.5%, respectively, after 5, 10, 15, and 20 years.1 These findings indicated that reactivation of hepatitis B tended to occur much more frequently during the first 10 years of follow-up and became relatively uncommon 15 years later. Furthermore, the natural course following spontaneous hepatitis B e antigen (HBeAg) seroconversion has been studied in two different cohorts from our unit, one involving 283 patients with HBeAg-positive chronic hepatitis B2 and the other involving 240 HBeAg-positive carriers.3 The annual rates of reactivation of hepatitis B were 3.3% and 2.2% per year, respectively.2, 3 The cumulative probability of HBeAg-negative chronic hepatitis B after 15 years was about 23%.2 Reactivation of hepatitis B occurred much more frequently during the first 10 years after HBeAg seroconversion.2 On the basis of the data of these studies, the overall incidence of reactivation of hepatitis B following HBeAg seroconversion was estimated to be as high as 25%. Accordingly, in Taiwan, following HBeAg seroconversion, only 25% of HBsAg carriers will go through the fourth phase, while the other 75% of HBsAg carriers will stop at the third phase as inactive carriers with lifelong sustained remission of hepatitis. Perhaps the incidence of reactivation of hepatitis B may be much lower for HBsAg carriers from low-endemic or intermediate-endemic areas.4 Therefore, we preferred to divide the natural course of chronic hepatitis B virus infection into three phases, because the division of the natural course of chronic hepatitis B into four phases likely will give us a misimpression that all or the majority of HBsAg carriers will go through the four phases. Chia-Ming Chu M.D.*, * Liver Research Unit, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan.
New developments in cardiothoracic surgery
Authors: D. G. Mulder
Journal: JAMA (1977)

New and innovative developments in cardiothoracic surgery include the pulmonary effects of certain inotropic drugs, the role of patent ductus closure in neonatal respiratory distress syndrome, the use of immunostimulating agents as adjuvants in the treatment of cancer of the lung, ingenious operative procedures to correct transposition of the great vessels and aortic stenosis, and improved methods to protect and assist the heart during cardiac operations. (<i>JAMA</i>237:2315-2317, 1977)
Measles immunization
Authors: P. Gunby
Journal: JAMA (1978)

Young people grow weary of hearing that they hold the key to the future. But, for the future government goal of eliminating indigenous measles by Oct 1,1982, immunization of adolescents and young adults indeed may be the key. An increasing proportion of the rubeola reported in this country is among the junior-high to young-adult group. Until recently this particular pattern of measles transmission escaped the attention of most epidemiologists. Before the vaccine came into use 15 years ago, 90% of cases of measles occurred in children under the age of 10. Now, according to a report given by A. David Brandling-Bennett, MD, at the American Public Health Association (APHA) meeting in Los Angeles, 60% of reported cases involve persons<i>over</i>10 years of age. Looking at it another way, officials at the Center for Disease Control (CDC), Atlanta, where Brandling-Bennett is chief of the Surveillance and Assessment Branch, report there
Percutaneous transluminal angioplasty of the renal arteries
Authors: D. C. Levin
Journal: JAMA (1984)

Percutaneous transluminal angioplasty (PTA) of renal artery stenosis has proved highly efficacious, particularly in patients with lateralizing renal vein renin ratios, fibromuscular dysplasia, and atherosclerotic lesions confined to one renal artery without involvement of the aortic wall surrounding the renal ostium. In some series, a moderate recurrence rate has been reported, but these recurrences usually respond well to redilatation. Complications are relatively rare and generally not serious. Early results compare favorably with those of large surgical series. Some of the disparities in published results of renal PTA may be accounted for by differences in technique. Important advances in both equipment and PTA technique have occurred since the procedure was introduced in 1978; these may prove to favorably affect the long-term results. (<i>JAMA</i>1984;251:759-763)
Miscellanea Medica
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Council on Drugs. List No. 89. New names
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sodium sulfate infusions and hypercalcemia
Authors: J. Lemann
Journal: JAMA (1965)

Life-threatening hypercalcemia may occasionally be responsible for the primary symptoms among patients with different diseases affecting calcium metabolism. In these circumstances there is a need for methods that will rapidly lower the serum calcium to less dangerous levels while various diagnostic studies are carried out and difinitive treatment is planned. During the past few years there has been interest in the use of infusions of sodium sulfate to promote renal excretion of calcium and thus combat hypercalcemia. Walser and his associates have demonstrated that sodium sulfate lowers serum calcium levels by markedly accelerating urinary calcium excretion when large quantities of the drug are infused rapidly into dogs.<sup>1</sup>In addition, they have reported, in abstract, that sodium sulfate infusions are accompained by some lowering of serum calcium levels in patients with hypercalcemia secondary to malignant diseases.<sup>2</sup>Recently, a marked fall in serum calcium was reported in association with the
Contents
Authors: Rizwan Malik, Anne Belliveau, Glen Sharpe, Lesya Shuba, Balwantray Chauhan, Marcelo Nicolela, J Michaël, Meghna Beotra, Sing Khai, Amanjeet Chin, Monica Sandhu, Eleni Clemo, Deborah Nikita, Maria Kamal, Jean Fraco, Nicholas Strouthidis, Marco Yu, Chen Lin, Robert Weinreb, Gilda Lai, Vivian Chiu, Kai-Shun Leung, M Chb, Shi Song Rong, Yao Tang, Wai Chu, Li Ma, Jason Yam, Shu Tang, Jian Li, Hong Gu, Alvin Young, Clement Tham, Chi Pang, Youn Soh, Alan Suh, Robert Le, Joseph Clark, Jay Erie, Andrew Barkmeier, David Hodge, Michael Mahr, Atsuki Kume, Tomohiro Ohshiro, Yoichi Sakurada, Wataru Kikushima, Seigo Yoneyama, Kenji Kashiwagi, Robert Bhisitkul, Shilpa Desai, David Boyer, Srinivas Sadda, Kang Zhang, Yorihisa Kitagawa, Hiroyuki Shimada, Ryusaburo Mori, Kouji Tanaka, Mitsuko Yuzawa, Timothy Jackson, Riti Desai, Andrew Simpson, James Frcophth, Robert Petrarca, Kelly Frcophth, Janet Smith, Cornelius Wittes, Luke Lewis, Richard Membrey, Mark Haynes, David Costen, Alyson Steel, Usha Muldrew, Diana Fisher, Barbara Klein, Tien Wong, Jerome Rotter, Xiaohui Li, Sandi Shrager, Gregory Burke, Ronald Klein, Mary Cotch, Luiz Roisman, Qinqin Zhang, Ruikang Wang, Giovanni Gregori, Anqi Zhang, Chieh-Li Chen, Mary Durbin, Lin An, Paul Stetson, Gillian Robbins, Andrew Miller, Fang Zheng, Philip Rosenfeld, Ursula Greferath, Robyn Guymer, Kirstan Vessey, Kate Brassington, Erica Fletcher, Frida Dalin, Grazyna Adamus, Sufang Yang, Eva Landgren, Josefine Palle, Åsa Hallgren, Britt-Marie Frost, Therése Hugosson, Nils Landegren, Daniel Eriksson, Sten Andréasson, Khalid Tabbara, Olle Kämpe, Mohammad Alimohammadi, Alfred Sommer, Tammy Reply, Chunwei Kuang, Linda Zhang, Robert Zangwill, Felipe Weinreb, Chryssa Mcalister, Colin Reply
Journal: Ophthalmology (2016)
Lipoprotein(a) Concentration and Risk of Atherothrombotic Disease
Authors: Andrew G. Bostom
Journal: JAMA (1995)

<h3>To the Editor.</h3> —In their article, Dr Ridker and colleagues<sup>1</sup>reported that there was no prospective association between lipoprotein(a) [Lp(a)] concentration and the risk of stroke. The authors summarized briefly the results of prior prospective studies of Lp(a) as a risk factor for coronary artery disease; however, certain points raised in that discussion require clarification. Namely, two studies that used the arbitrary nomenclature "apo (a)" for apolipoprotein (a) as opposed to "Lp(a)" were addressed separately. With one exception,<sup>2</sup>all studies to date have detected Lp(a) using immunoassays directed against apo(a). For example, Ridker et al<sup>1</sup>refer to "Lp(a)" and Wald et al<sup>3</sup>in the article cited by Ridker et al refer to "apo(a)"; however, both groups used the Biopool ELISA (enzyme-linked immunosorbent assay). Thus, it is neither necessary nor appropriate to dichotomize studies based on differences in nomenclature. Therefore, among prior prospective studies of Lp(a) and
Vasoconstricting Drugs Raise Blood Pressure But Do Not Improve Tissue Metabolism
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal