tbuckley/cabot-search huggingface dataset:
Cardiovascular Autonomic Dysfunction in Africans Infected with Human Immunodeficiency Virus
Authors: Divine Nzuobontane, Blackett Kathleen Ngu, Kuaban Christopher
Journal: Journal of the Royal Society of Medicine (2002)

The effects of human immunodeficiency virus (HIV) on cardiovascular autonomic function have been little investigated in African patients. We performed standard heart-rate and blood pressure tests on 75 consecutive consenting patients referred for an HIV test in Yaounde, Cameroon. 54 patients proved to be HIV-infected (30 having progressed to AIDS). Cardiovascular autonomic dysfunction was present in 8 (28%) patients with AIDS and in 1 (4%) HIV-positive patient without AIDS; no HIV-negative individuals had abnormal results. If borderline results are included, over 80% of HIV-positive patients had cardiovascular autonomic dysfunction. In HIV-infected patients, simple tests such as blood pressure responses to standing or handgrip can warn of cardiovascular autonomic dysfunction, thus signalling the need for added precautions when invasive procedures are proposed.
Targeting autophagy potentiates tyrosine kinase inhibitor–induced cell death in Philadelphia chromosome–positive cells, including primary CML stem cells
Authors: Cristian Bellodi, Maria Rosa Lidonnici, Ashley Hamilton, G. Vignir Helgason, Angela Rachele Soliera, Mattia Ronchetti, Sara Galavotti, Kenneth W. Young, Tommaso Selmi, Rinat Yacobi, Richard A. Van Etten, Nick Donato, Ann Hunter, David Dinsdale, Elena Tirrò, Paolo Vigneri, Pierluigi Nicotera, Martin J. Dyer, Tessa Holyoake, Paolo Salomoni, Bruno Calabretta
Journal: Journal of Clinical Investigation (2013)

The bottom
Antibody responses in viral hepatitis, type B
Authors: L. F. Barker
Journal: JAMA (1973)

Most individuals with viral hepatitis, type B, acquire a serum antigen (hepatitis-B antigen [HB Ag])<sup>1</sup>at some time during the incubation period or the acute phase of the disease. Serial sera from 88 patients with viral hepatitis, type B, were examined for antibodies against HB Ag (anti-HB Ag) by passive hemagglutination (PHA) and radioimmunoassay (RIA) methods. Seventy individuals (79.5%) were found to develop serum anti-HB Ag at some time after exposure. Overt occurrences of hepatitis were usually followed by primary-type anti-HB Ag responses. However, early- or secondary-type anti-HB Ag responses were seen in 17 individuals who subsequently developed clinical hepatitis. Most individuals who were resistant to infection after parenteral exposure to materials known to transmit hepatitis had secondary antibody responses. We conclude that primary antibody responses to HB Ag are common after viral hepatitis, type B, and that protective immunity frequently but not invariably follows early exposure to hepatitis-B virus.
Adverse Events and Their Association With Treatment Regimens in the Diabetes Control and Complications Trial
Journal: Diabetes Care (1995)

OBJECTIVE To describe the incidence of adverse events associated with intensive versus conventional therapy of insulin-dependent diabetes mellitus (IDDM) as implemented in the Diabetes Control and Complications Trial (DCCT). RESEARCH DESIGN AND METHODS The DCCT was a randomized, controlled clinical trial conducted at 26 centers in the U.S. and 3 centers in Canada. All data were collected from patient notifications of events and/or standardized, quarterly interviews that were validated and analyzed at a data coordinating center as events per 100 patient-years. The 1,441 volunteers were between the ages of 13 and 39 with IDDM for 1–15 years. Average length of follow-up was 6.5 years (range 3–9). Subjects were randomly assigned to conventional or intensive diabetes treatment. RESULTS The two treatment groups did not differ in mortality, major morbidity secondary to accidents, or ketoacidosis. However, intensive therapy was associated with a threefold increase in the risk of severe hypoglycemia (for hypoglycemia requiring assistance, the event rate per 100 patient-years was 61.2 in the intensive treatment group versus 18.7 in the conventional treatment group; for hypoglycemia involving coma or seizure, the rate was 16.3 vs. 5.4). Intensive therapy was also associated with a 73% higher risk of becoming overweight. There was a 46% reduction in the incidence of vaginitis in the intensive treatment group, but there were no significant differences in the rates of other infections. CONCLUSIONS The major adverse effect of intensive therapy of IDDM is a threefold increase in the risk of severe hypoglycemia with potentially serious sequelae. An increased incidence of becoming overweight, the long-term significance of which has yet to be determined, was also observed. Because the results of the DCCT were attained in highly selected, healthy IDDM patients who received attentive clinical management and frequent health education, DCCT adverse event rates may not reflect incidence or prevalence rates that would be expected in nonselected populations or in other clinical settings.
THE SURGERY OF THE URETERS: A CLINICAL, LITERARY AND EXPERIMENTAL RESEARCH.Read in the Section on Surgery and Anatomy at the Forty-fourth Annual Meeting of the American Medical Association June 8, 1893.
Authors: WELLER VAN HOOK
Journal: JAMA (1893)

SYNOPSIS. 1. Introductory remarks. 2. Anatomical considerations. 3. Wounds of the ureter. A. Drainage. B. Bacterial conditions, asepsis, sepsis, putrefaction. C. Location; pelvis, continuity, outlet (male and female). D. Relation to injury of other structures. E. Direction of the wound. 1. Longitudinal. <i>a</i>. Drainage and its relation to the peritoneum. <i>b</i>. Suture; utility and advisability. 2. Transverse wounds. <i>a</i>. Incomplete, drainage, suture. <i>b</i>. Complete transverse injury without loss of substance. 1. In the continuity of the ureter. Suture. Special devices. The writer's method. 2. At renal extremity. 3. At vesical extremity. <i>c</i>. Complete transverse injury with loss of substance. 1. Urine still made to enter the bladder by A. Using foreign bodies to produce a connective tissue channel into the bladder. B. By double implantation of the ureter into an isolated knuckle of the bowel. C. The writer's plastic methods of extending the bladder to meet the ureter. <i>a</i>. Extra-peritoneal
Senate Bill No
Journal: JAMA (1976)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
'Office Difficulties' Plague Physicians
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Alcohol-induced liver injury is attenuated by human beta defensin in experimental ALD via improvements in the gut-liver axis
Authors: Jeffrey Warner, Ida Larsen, Dennis Warner, Josiah Hardesty, Ying Song, Rui Sun, Zhongbin Deng, Peter Nordkild, Craig J. McClain, Benjamin Jensen, Irina Kirpich
Journal: Journal of Hepatology (2020)
Kyrie: Poems
Authors: William H. McNeill
Journal: JAMA (1996)

Kyrie is a collection of poems about the 1918-1919 influenza pandemic, reminiscent of Edgar Lee Masters' Spoon River Anthology. In the informative afterword, the author writes, "In one year, one quarter of the total U.S. population contracted influenza; one out of five never recovered. Nevertheless, the national memory bears little trace." The following poem from the collection is reprinted by permission of the publisher (copyright 1995 by Ellen Bryant Voigt): Circuit rider, magic leather credential at my feet with its little vials of morphine and digitalis, I made my rounds four days at a stretch out from the village, in and out of their houses and in between, in sunlight, moonlight, nodding on the hard plank seat of the buggy— it didn't matter which turn the old horse took: illness flourished everywhere in the county. At Foxes' the farmhouse doors were barred by snow; they prised a board from a
Administrative Case Rounds
Authors: Stanley Joel Reiser
Journal: JAMA (1991)

GOVERNING the institutions of health care provision is becoming increasingly difficult. This is largely caused by an accelerating pace of technological innovation that alters their financial status and internal structure, a growing number of constituencies in society that demand authority to influence institutional policies, and a widening gap between the professional and administrative staff of institutions concerning goals and purpose. To better cope with these issues, institutional leaders should recognize and learn to fulfill effectively the pedagogic role they take on for their staff and constituents when they create and carry out policy. They also should consider holding regular discussions about institutional policy alternatives within the framework of one of the most significant and powerful means of teaching and research in medicine—the case round. In reaching decisions, administrators who govern health care institutions, such as hospitals or health science centers, frequently separate the policies developed to guide institutional action from
Hospital Museum
Authors: Joan Baranow
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Atlas der Erkrankungen der oberen Luftwege mit besonderer Berücksichtigung des Epipharynx.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BUDAPEST
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Why Celebrate?
Authors: Lester S. King
Journal: JAMA (1976)

We are now celebrating the 200th anniversary of the Declaration of Independence—not the signing of that document but its assertion; literally, the<i>declaration</i>. In any such celebration, the personal reactions will vary. There may be thankfulness that we have passed a milestone; or pride in comparisons with the past— "That was the way things were then, but<i>this</i>is the way they are now"; or humility that the present is so imperfect and that so much remains to be done. But in the present bicentennial year, what is specifically medical? Why should physicians as a professional group make any special commemoration? The bicentennial celebration gives physicians an opportunity to think about the past and its relation to the present, not in regard to political events but rather in regard to our medical heritage and medical problems. There is an invitation to become, for a short time, a historian. Many people
Measles campaign
Authors: K. C Calman
Journal: BMJ (1995)

and 73% (3147/4286) in those in category 7.Conversely, the proportions of pregnancies that resulted in termination were 50% (362/731) in women in deprivation category 1 and 14% (602/4286) in those in category 7. When planning health services to meet the needs of the population it is obviously essential to have information by deprivation category.
Sampling of Vehicle Emissions for Chemical Analysis and Biological Testing
Authors: Dennis Schuetzle
Journal: Environmental Health Perspectives (1983)

Representative dilution tube sampling techniques for particulate and gas phase vehicle emissions are described using Teflon filter media and XAD-2 resin. More than 90% of the total gas (C8-C18) and particulate direct acting Ames assay mutagenicity (TA 98) was found in the particulate phase. The gas and particulate phase material was fractionated by HPLC into nonpolar, moderately polar and highly polar chemical fractions. The moderately polar chemical fraction of the particulates contained more than 50% of the direct acting Ames assay mutagenicity for the total extract. The concentration of oxygenated polynuclear aromatic hydrocarbons (oxy-PAH) and nitrated PAH (nitro-PAH) identified in the moderately polar particulate fractions are given. Nitro-PAH account for most of the direct-acting (TA 98) Ames assay mutagenicity in these moderately polar fractions. Reactions and kinetic expressions for chemical conversion of PAH are presented. Chemical conversion of PAH to nitro-PAH during dilution tube sampling of particulates on Teflon filters and gases on XAD-2 resin is a minor problem (representing 10-20%, on the average, of the 1-nitropyrene found in extracts) at short (46 min) sampling times, at low sampling temperatures (42 degrees C), and in diluted exhaust containing 3 ppm NO2. Particulate emissions collected from dilution tubes on filter media appear to be representative of what is emitted in the environment as based upon a comparison of highway and laboratory studies.
TETRALOGY OF FALLOT
Journal: JAMA (1961)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The contrasting effects of dopamine and norepinephrine on systemic and splanchnic oxygen utilization in hyperdynamic sepsis
Authors: P. E. Marik
Journal: JAMA (1994)

<h3>Objective.</h3> —To compare the effects of dopamine and norepinephrine on systemic and splanchnic oxygen utilization in patients with hyperdynamic sepsis. <h3>Design.</h3> —A randomized short-term, interventional study. <h3>Setting.</h3> —An intensive care unit of a university hospital. <h3>Patients.</h3> —Twenty septic patients with a cardiac index greater than 3.2 L.min<sup>-1</sup>.m<sup>-2</sup>and either a mean arterial pressure (MAP) less than 60 mm Hg or a systemic vascular resistance index less than 1200 dyne.s.cm<sup>-5</sup>.m<sup>-2</sup>. <h3>Methods and Interventions.</h3> —Patients were randomized to receive an infusion of either dopamine or norepinephrine titrated to increase the MAP to greater than 75 mm Hg. The hemodynamic profile, oxygen delivery, oxygen consumption (determined by indirect calorimetry), and gastric intramucosal pH (pHi) (determined by gastric tonometry) were determined at baseline and after 3 hours of achieving the target MAP. <h3>Results.</h3> —Dopamine increased the MAP largely by increasing the cardiac index whereas norepinephrine increased the MAP by increasing the systemic vascular resistance index while maintaining the cardiac index. Although oxygen delivery and oxygen consumption increased in both groups of patients, the pHi increased significantly in those patients treated with norepinephrine whereas the pHi decreased significantly in those patients receiving dopamine (<i>P</i>&lt;.001, for corrected 3-hour value). <h3>Conclusions.</h3> —This study suggests that dopamine may cause an uncompensated increase in splanchnic oxygen requirements in septic patients. Norepinephrine, however, may have a more favorable hemodynamic profile and improve splanchnic tissue oxygen utilization in sepsis. (<i>JAMA</i>. 1994;272:1354-1357)
Book Review Gonorrhea and Kindred Affections . Gonorrhea in the male, Chancroid and Verruca Acuminata. By George Robertson Livermore, M.D., F.A.C.S., Professor of Urology, Medical Department, University of Tennessee, etc.; and Gonorrhea in the female, and the Infectious Granulomata. By Edward Armin Schumann, A.B., M.D., F.A.C.S. Associate Professor of Obstetrics, University of Pennsylvania.
Journal: New England Journal of Medicine (1929)
Cyclosporine: vital in today's transplantation, but questions remain about tomorrow
Authors: T. Randall
Journal: JAMA (1990)

THE PACE of transplantation has accelerated from a crawl to a sprint since the advent of cyclosporine. But a decade out of the starting blocks, this immuno-suppressant's Achilles' heel, renal toxicity, is beginning to throb. Whether this throb will prove manageable with lower doses and careful monitoring or will eventually disqualify this lifesaving drug from long-term immunosuppression therapy has fueled a long-standing controversy within the transplantation community. Most needed and yet noticeably absent from these debates has been the element of time. Patient and graft survival curves when cyclosporine is used extend 9 or 10 years at most, yet endstage renal failure can take decades to develop. Hypertension, hypercholesterolemia, and diabetes—other risk factors associated with the concomitant use of steroids—also loom over the survival curves. How many years after transplantation, if ever, will the penalty paid by the "innocent bystanders," that is, the nontransplanted organs, outweigh the benefits? Recently, participants
Little consensus on prescribing of estrogens for postmenopausal women
Authors: J. Elliott
Journal: JAMA (1979)

The latest consensus development conference at the National Institutes of Health tackled the thorny problem of estrogen replacement therapy for postmenopausal women. Those at the meeting, sponsored by the National Institute of Aging, concluded that exogenous estrogens clearly have been shown to increase the risk of endometrial cancer. The hormones are effective, however, in controlling the vasomotor symptoms, atrophy of vaginal epithelium, and osteoporosis that often accompany menopause. Still, aside from discouraging high-dose or longterm use of estrogen therapy, the consensus panel refrained from formulating specific guidelines for the prescribing of estrogens for postmenopausal women. They concluded, rather, that physicians should discuss the benefits and risks of the treatment with each patient and then leave the final decision up to her. Currently fewer than 7 million of the more than 30 million American women past menopause are using estrogens. In contrast, about 20 million prescriptions for the various estrogen compounds