tbuckley/cabot-search huggingface dataset:
Part 2: Abstracts from the NCCN 19th Annual Conference: Advancing the Standard of Cancer Care™
Authors: Samuel Gaster, Julie Dixen, Kristine Gaster, Stefan Glück, Jivesh Sharma, Peter Belafsky, Mary Delmedico, Susan Spruill, Liz Rolison, David Drutz
Journal: Journal of the National Comprehensive Cancer Network (2014)

Background: From soma to psyche, the effects of cancer extend well beyond abnormal, uncontrollable cells or invaded tissue to far within the deepest areas of a person's mind, body, and spirit (van der Kolk, 1996; Institute of Medicine, 2008).Consequently, patients with cancer often experience a range of physical, psychological, and spiritual problems.Therefore, to provide the highest quality of care empirically-validated models should be adopted to provide routine psychosocial services that address these complex needs (IOM, 2008; IOM, 2013).Recently, the Avera Cancer Institute in Sioux Falls, South Dakota, adopted the NCCN Guidelines for Distress Management.These guidelines were used to develop a protocol to assess the level and nature of patients' distress using the NCCN Distress Thermometer and refer patients to support staff based on their responses to a 46-item adapted Problem List.Compliance was evaluated using the American Psychosocial Oncology Society's quality indicators for psychosocial care.Methods: Data include audits of 1544 office visits in the medical oncology clinic at the Avera Cancer Institute from October 7th to November 29th, 2013.For data analysis, charts were first reviewed for evidence that current distress was screened.Next, records were evaluated for evidence that problems were assessed in each office visit when moderate to severe distress (ie, >3) was reported.Third, charts were assessed for evidence that action was taken to address reported problems.Results: Results indicate that current distress was assessed in 1488 (96.37%) of the 1544 office visits and that policy compliance was observed in 1522 office visits (98.58%).Of the 1488 office visits in which distress was screened, moderate to severe distress (ie, >3) was reported in 361 (24.26%), and of these, the nature of patients' distress, or their problem areas, were assessed in 322 of the visits (89.20%).Lastly, evidence of action taken to address patients' problems was available for 361 (100%) of the office visits in which patients expressed moderate to severe distress, with referrals documented in 129 (35.73%) of these visits and evidence of patient refusal in 232 (64.27%).Conclusions: These results indicate a high compliance with guidelines for effective distress management and quality indicators for psychosocial care.This project also provides support for increased multidisciplinary and collaborative care to meet certain needs, including depression and traumatic stress.Thus, future efforts should be made to include a more formal model to address these needs.It is possible that existing models within primary care may prove useful to deliver such services.
A Novel Role Of Tescalcin-Sodium/Hydrogen Exchange Axis Underlying Sorafenib Resistance In FLT3-ITD+ AML
Authors: Cheuk Him Man, Anskar Y.H. Leung, Stephen Sze Yuen Lam, Murphy Ka Hei Sun, Howard Chun Hung Chow, Harinder Gill, Yok Lam Kwong
Journal: Blood (2013)
Telomerase Activity in Well-Differentiated Papillary Thyroid Carcinoma Correlates with Advanced Clinical Stage of the Disease
Authors: Leticia Bornstein-Quevedo, M. L. García-Hernández, Ignacio Camacho-Arroyo, Miguel F. Herrera, Arturo Angeles Angeles, Ofelia González Treviño, Armando Gamboa-Domínguez
Journal: Endocrine Pathology (2003)
Errors in Hazard Ratios, Labels in Figures, and Text
Authors: Kerstin Eitz
Journal: JAMA Oncology (2020)

Kerstin A. Eitz, PhD; Simon S. Lo, MD; Hany Soliman, MD; Arjun Sahgal, MD; Aimee Theriault, MD; Mark. B. Pinkham, MD; Matthew C. Foote, MD; Andrew J. Song, MD; Wenyin Shi, MD; Kristin J. Redmond, MD; Chenchen Gui, MD; Aryavarta M. S. Kumar, MD; Mitchell Machtay, MD; Bernhard Meyer, MD; Stephanie E. Combs, MD
History and Bibliography of Anatomic Illustration in Its Relation to Anatomic Scienie and the Graphic Arts.
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Peritoneal response to injury--clinical and experimental aspects
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Highlights
Journal: JAMA (2018)

Treatments for Ceftriaxone-Resistant Infections 984Alternatives to carbapenem antibiotics are needed for the treatment of infections caused by ceftriaxone-resistant bacteria to avoid the emergence of carbapenem resistance.Harris and colleagues for the MERINO Trial Investigators and the Australasian Society for Infectious Disease Clinical Research Network randomized 379 patients who had bloodstream infections with ceftriaxone-resistant Escherichia coli or Klebsiella pneumoniae and found that treatment with piperacillin-tazobactam compared with meropenem did not result in a noninferior outcome of 30-day mortality.In an Editorial, Hayden and Won recommend studies of novel therapies to limit carbapenem exposure.Editorial 979 CME jamanetwork.com/learning Levofl oxacin to Prevent Bacteremia 995Bacteremia is a leading cause of morbidity and mortality in children receiving chemotherapy for leukemia or undergoing hematopoietic stem cell transplantation.In a randomized trial by Alexander and colleagues for the Children's Oncology Group that enrolled 624 patients, levofl oxacin prophylaxis reduced the incidence of bacteremia in children with leukemia but not in children undergoing hematopoietic stem cell transplantation.
An influenza B epidemic within a remote Alaska community. Serologic, epidemiologic, and clinical observations
Authors: P. S. Clark
Journal: JAMA (1970)

During January 1969 an epidmic of influenza B was documented in Klawock, Alaska, a remote insular community 80 miles west of Ketchikan. One person died and 149 others developed an acute respiratory disease characterized by fever, cough, headache, and coryza. A fourfold or greater rise in hemagglutination-inhibiting (HI) antibody titer to influenza B developed in 26 persons, and influenza B virus was isolated from 5 patients. Reciprocal HI testing of the Alaska strain (B/Alaska/4-69) did not disclose a significant antigenic difference from the vaccine strain (B/Massachusetts/3-66). However, 36 of the 46 persons who had been vaccinated during the preceding 3 to 12 months developed clinical influenza, and the attack rate within this group did not differ significantly from the attack rate among the unvaccinated population.
Research in emergency circumstances
Authors: C. Marwick
Journal: JAMA (1995)

THE PERFORMANCE of clinical research under emergency circumstances, when the patient is unable to give consent, has come to a virtual halt. Where it is still being done, it is in danger of being seriously compromised. The situation is of concern to researchers, review bodies, and regulators. To discuss the problem and try to resolve the issues, the Food and Drug Administration (FDA) and National Institutes of Health (NIH) convened a public forum in January. While hardly new, the situation has surfaced only relatively recently because of two principal developments. The first is the appearance of several new and potentially useful treatments for lifethreatening conditions such as stroke, cardiac arrest, and traumatic injury. These treatments require evaluation for clinical effectiveness. The second is that both the NIH and FDA—the two agencies mainly responsible for overall review of clinical research studies—have recently stopped or otherwise curtailed a number of clinical studies
Acute bacteremia in asplenic renal transplant patients
Authors: G. P. Schroter
Journal: JAMA (1977)

Four cases of overwhelming bacteremia were observed in asplenic renal transplant patients 12 to 20 months after transplantation. The bacteriologic findings and presentation of these infections are characteristic of postsplenectomy sepsis reported in nontransplant patients. It is suggested that the absence of the spleen, more than immunosuppression with azathioprine and prednisone, predisposes to these late, uncommon infections after transplantation. (<i>JAMA</i>237:2207-2208, 1977)
Books Received
Journal: JAMA (1981)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
In-vitro delivery of non-stimulatory cardiac contractility modulating electric signals improve intrinsic contractile function of cardiomyocytes isolated from dogs with chronic heart failure Victor A. Maltsev, Bella Felson, Yuval Mika, Nissim Darvish, Sidney Goldstein, Shlomo Ben-Haim, Hani N. Sabbah. Henry Ford Health System, Detroit, MI
Journal: Journal of the American College of Cardiology (2001)
The Pathogenesis of Cardiac Cachexia
Authors: Joseph G. Pittman, Phin Cohen
Journal: New England Journal of Medicine (1964)

Cellular HypoxiaThe air hunger of congestive heart failure calls attention to the role of chronic cellular hypoxia in the pathogenesis of cardiac cachexia. One would anticipate that prolonged circulatory failure could lead to a cellular oxygen lack, which in turn would derange the delicate balance between anabolic and catabolic processes. Although easily stated, this hypothesis is less easily proved.Blood gas studies in congestive heart failure are plentiful5,15,25,26,30,39, 73 74 75 and show in general normal or only slightly reduced arterial oxygen tensions and saturations, with normal carbon dioxide contents and tensions, although there is often a tendency toward hypocapnia because of . . .
Blood, New York
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Erratum: The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions
Authors: Hamid Bolouri, Jason E Farrar, Timothy Triche, Rhonda E Ries, Emilia L Lim, Todd A Alonzo, Yussanne Ma, Richard Moore, Andrew J Mungall, Marco A Marra, Jinghui Zhang, Xiaotu Ma, Yu Liu, Yanling Liu, Jaime M Guidry Auvil, Tanja M Davidsen, Patee Gesuwan, Leandro C Hermida, Bodour Salhia, Stephen Capone, Giridharan Ramsingh, Christian Michel Zwaan, Sanne Noort, Stephen R Piccolo, E Anders Kolb, Alan S Gamis, Malcolm A Smith, Daniela S Gerhard, Soheil Meshinchi
Journal: Nature Medicine (2018)
Statin use at the time of initiation of androgen deprivation therapy and time to progression in patients with hormone-sensitive prostate cancer.
Authors: Lauren Christine Harshman, Xiaodong Wang, Mari Nakabayashi, Wanling Xie, Loana Bueno Valenca, Lillian Werner, Yongjiang Yu, Aaron Kantoff, Christopher Sweeney, Lorelei A. Mucci, Mark Pomerantz, Gwo-Shu Mary Lee, Philip W. Kantoff
Journal: Journal of Clinical Oncology (2015)

5024 Background: Statin use has been associated with improved prostate cancer outcomes such as decreased risk of recurrence after local therapy and a lower risk of prostate cancer mortality. DHEAS is a precursor of testosterone and a substrate for SLCO2B1, an organic anionic transporter. We previously demonstrated that genetic variants of SLCO2B1 correlated with time to progression (TTP) on androgen deprivation therapy (ADT). Statins utilize SLCO2B1 to enter cells, thus, we hypothesized that statin use at ADT initiation might prolong TTP by competing with DHEAS uptake. Methods: To determine if statins interfere with DHEAS uptake, we performed in vitro studies using prostate cancer cell lines. Next, we queried our institutional clinical database for patients treated with ADT for biochemical or metastatic recurrence or de novo metastatic prostate cancer (ADT cohort). The association between statin use and TTP on ADT was estimated using multivariable Cox regression and adjusted for known prognostic factors. Results: In vitro, we demonstrated that statins block DHEAS uptake by competitively binding to SLCO2B1. In our ADT cohort of 926 patients treated between January 1996 and November 2013, 283 (31%) were taking a statin at ADT initiation. After a median follow-up of 5.8 years, 644 patients (70%) had progressed on ADT. Median TTP on ADT was 20.3 months (95% CI: 18,24). Men on statins had a longer median TTP on ADT compared to non-users (27.5 vs. 17.4 months, p = 0.0005). The association remained statistically significant after adjusting for pre-defined prognostic factors [adjusted HR = 0.83 (p = 0.039)]. The positive statin effect was observed for both patients with and without metastases. Conclusions: Statin use at ADT initiation was associated with a significantly longer TTP on ADT even after adjusting for known prognostic factors. Our in vitro findings that statins competitively reduce DHEAS uptake and thus, effectively decrease the available intratumoral androgen pool, afford a plausible mechanism to support the clinical observation of prolonged TTP in statin users.
Neonatal herpetic infection. A fatal consequence of penile herpes in a serviceman
Authors: J. H. Zavoral
Journal: JAMA (1970)

A fatal case of disseminated herpetic infection occurred in a newborn whose mother had primary genital type 2 herpes. The source of the infection was the father, a serviceman who returned from overseas with active penile herpes one week prior to his wife's delivery. Cesarean section, after rupture of membranes, failed to prevent the infant from acquiring the infection. Pregnant women, particularly in the last trimester, should avoid contact with males with known penile herpes.
Prevalence of Arthritis—United States, 1997
Journal: JAMA (2001)

Arthritis and other rheumatic conditions (i.e., arthritis) are among the most prevalent diseases in the United States (1) and the most frequent cause of disability (2). In 1985, an estimated 35 million persons were affected by arthritis (3); in 1990 (1), a study using a broader arthritis definition estimated that 38 million were affected. To better characterize these conditions, CDC analyzed a variety of data for 1997 using common definitions from the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM). The findings of one such analysis in the National Health Interview Survey (NHIS) indicated that, in 1997, the prevalence of persons with arthritis had increased by approximately 750,000 per year since 1990. Findings also support earlier projections that by 2020, 60 million persons may be affected by arthritis and that the activities of 11.6 million persons may be limited by arthritis (1). More widespread implementation of existing interventions may reduce the occurrence and progression of arthritis.
The Yugoslavia Prospective Study of Environmental Lead Exposure
Authors: Pam Factor-Litvak, Gail Wasserman, Jennie K. Kline, Joseph Graziano
Journal: Environmental Health Perspectives (1999)

The Yugoslavia Prospective Study of environmental lead exposure has studied the associations between exposure to lead and pregnancy outcomes; childhood neuropsychological, behavioral, and physical development; and hematologic, renal, and cardiovascular function. The cohort comprises 577 children born to women recruited at midpregnancy in two towns in Kosovo, Yugoslavia; one town is the site of a lead smelter, refinery, and battery plant and the other is 25 miles away and relatively unexposed. A sample of these children has been followed at 6-month intervals through 7.5 years of age. Blood lead concentrations ranged from 1 to 70 microg/dl. Exposure to lead was not associated with adverse pregnancy outcomes. Exposure was associated with modest decrements in intelligence, small increases in blood pressure, higher risks of proteinuria, small increases in behavior problems, and perturbed hematopoiesis. Only at low level exposures (i.e., <16 microg/dl) were small associations with decreased height found. We discuss methodological problems that may hinder causal interpretation of these data, namely, use of blood lead concentration as an exposure measure, confounding, and town-specific associations. We conclude that while reported associations are small, collectively they lend support to the notion that lead is a toxicant with numerous adverse health effects.
Announcements
Journal: Neuro-Oncology (2000)

The American Brain Tumor Association (ABTA) proudly announces their intention to award $685,000 in awards for basic, translational, and clinical research this year.Fellowships are $60,000, payable over 2 years.Qualified applicants are MDs within 2 years of residency completion or PhDs with no more than 30 months of postdoctoral laboratory experience
Radiotherapy after definitive surgery for breast cancer
Authors: S. H. Levitt
Journal: JAMA (1977)

(1) Radiotherapy after definitive surgery for breast cancer has not been proved to have a deleterious effect on patient survival. (2) The beneficial effect of radiation therapy is to decrease significantly local recurrences (<i>P</i>&lt;.001), which are very difficult to control once they develop. (3) In the hands of experienced radiotherapists, the incidence of complications is quite low. (4) Adjuvant chemotherapy effects on the prevention of local recurrence are most encouraging but still experimental and should at this stage be used mainly in study situations. (5) Until more detailed information is obtained, radiation therapy remains the most effective, least toxic method for the control of local disease. (<i>JAMA</i>237:153-155, 1977)
Parasite Transmission
Authors: Howard B. Shookhoff
Journal: JAMA (1972)

<h3>To the Editor.—</h3> The writer of the letter titled "Snakes in the Grass, Or, the Worm Turns On" (221:917, 1972) has provided your readers with a bit of rib-tickling rhetoric, but more than a modicum of misinformation. One must take exception not only to the doses of pyrvinium pamoate for<i>Enterobius vermicularis</i>infection, the use of furazolidin for<i>Dientamoeba fragilis</i>infection, and the homeopathic dose of diiodohydroxyquin, but also to the assumption that raw marihuana was the cause of this kaleidoscopic array of parasitic infections. Such a panoramic succession of single or combined infections is not unusual in the experience of myself and my associates among male homosexuals. Given the multiplicity and versatility of sexual contacts in this group, it is not surprising that fecaloral transmission of a variety of infectious agents occurs frequently. The source is much more likely to be venereal than vegetable.
Penetration of Cells by Asbestos Fibers
Authors: J. M. G. Davis, R. E. Bolton, J. Garrett
Journal: Environmental Health Perspectives (1974)

Studies on the behavior of asbestos fibers within tissues have shown that the only cells that regularly contain asbestos are macrophages and their derivatives. However, these cells actively incorporate the asbestos fibers by the process of phagocytosis, and there is little evidence of direct penetration. Examination of the gut lining after prolonged asbestos ingestion has shown no evidence of dust penetration either through or between the epithelial cells. The structure and arrangement of these cells is discussed, and it is suggested that they are exceptionally well adapted to prevent penetration by any solid material.
Frequency of appropriate shocks in the patients with implanted defibrillators for MADIT (Multicenter Automatic Defibrillator Implantation Trial) or MUSTT (Multiple Unsustained Tachycardia Trial) criteria Gunjan J. Shukla, S. Dinakar Satti, G. Muqtada Chaudhry, Patricia E. Pacetti, Thomas F. Marchese, Charles I. Haffajee. St. Elizabeth's Medical Center, Boston, MA, Tufts University School of Medicine, Boston, MA
Journal: Journal of the American College of Cardiology (2001)