tbuckley/cabot-search huggingface dataset:
Purified Candida albicans proteinase in the serological diagnosis of systemic candidosis
Authors: F. Macdonald
Journal: JAMA (1980)

An inducible, exocellular proteinase enzyme, purified from culture filtrates of<i>Candida albicans</i>, was tested as an antigen for the detection of serum anti-<i>Candida</i>precipitins. The purified proteinase was a more specific antigen for the serological diagnosis of systemic candidosis than traditional cytoplasmic extracts of the fungus. Precipitin titers to purified proteinase exceeded 1:4 in 75% of serum samples from 12 patients with confirmed systemic<i>Candida</i>infection, in 23% of serum samples from 22 patients positive for<i>Candida</i>anticytoplasm antibodies but without corroborative diagnostic evidence of systemic candidosis, and in none of 28 serum samples from patients without either candidosis or anticytoplasm antibodies. (<i>JAMA</i>243:2409-2411, 1980)
Debates
Journal: JAMA (1961)

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Neonatal Resuscitation
Authors: K Shaffer
Journal: JAMA (1992)

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Acta Soc Med Upsaliensis, Uppsala
Journal: JAMA (1965)

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Interim results of PEANUT: pembrolizumab and nanoparticle albumin-bound paclitaxel (nab-paclitaxel) as salvage therapy for metastatic urothelial carcinoma (UC).
Authors: Andrea Necchi, Daniele Raggi, Marco Bandini, Elena Farè, Patrizia Giannatempo, Maurizio Colecchia, Filippo Pederzoli, Andrea Gallina, Laura Marandino, Giuseppina Calareso, Russell Madison, Alberto Briganti, Jeffrey S. Ross, Francesco Montorsi
Journal: Journal of Clinical Oncology (2020)

494 Background: Pembrolizumab (pembro) is a new standard of care in chemotherapy (CT) pre-treated patients (pts) with metastatic UC. Nab-paclitaxel (nPtx) demonstrated preliminary activity in advanced UC. In the PEANUT study (NCT03464734) we investigate their combination in advanced UC after CT failure. Methods: In an open-label, single-arm, phase 2 trial, pts receive 200 mg pembro, intravenously (IV), on D1 and 125 mg/m 2 IV nPtx on D1 and D8, every 3 weeks, until disease progression (PD) or onset of unacceptable toxicity. Key inclusion criteria are: predominant UC histology, failure of ≤2 platinum-based CT for metastatic disease. Response is evaluated by RECIST v.1.1 criteria every 2 cycles. Biomarkers include PD-L1 expression with the combined positive score (CPS) and comprehensive genomic profiling on tumor and blood samples (FoundationONE and FoundationACT assay). The primary endpoint of the study is the progression-free survival (PFS). The target is to detect an improvement in the median PFS from ≤3.0 months (H0) to ≥5.0 months (H1). Results: Between 01 and 08/2019, PEANUT enrolled 46 pts evaluable for the study endpoint: 26% female, median age 66 y (range 43-78); 70% had failed 1 prior systemic therapy vs 30% 2 prior therapies; 24% had ECOG-performance status 1; 28% had liver metastases. The median TMB was 6.9 mut/Mb. After median follow-up of 5 months, 18 pts have relapsed (39%). The projected median PFS was 7 months (95%CI: 4-not achieved). The confirmed objective response-rate (ORR) was 47.8% (95%CI: 32.9-63.1): 18 partial responses and 4 complete responses (8.7%). Grade 3 treatment-related adverse events (TRAE) were seen in 6 pts (13%). Most common any-grade TRAE included alopecia (91%), asthenia (21.7%), and neutropenia (15%). Neither TMB nor CPS were significantly associated with PFS on univariable analyses. 7/8 pts with PI3KCA mutations in matched tumor/blood samples had an objective response (87.5%). Conclusions: Preliminary results from PEANUT study demonstrated a promising PFS and a clinically meaningful ORR in II-III line setting of advanced UC. Updated data, including mature PFS, duration of response and biomarkers will be presented. Clinical trial information: NCT03464734.
Algorithm for modified alkaline diuresis in salicylate poisoning
Authors: Nicholas Treble, Nigel Henderson, Hasmukh Dasani, Mr Treble
Journal: BMJ (1984)

but a low titre to the porcine agent.3Before operation a test dose was given to ascertain the therapeutic response and to detect side effects.4In this case shivering, nausea, and back pain occurred but were rapidly relieved by oral chlorpheniramine.During the early post- operative period we gave 100 mg hydrocortisone and 10 mg chlorpheniramine intravenously before each infusion, later using chlor- pheniramine alone.The platelet count remained unchanged.Altogether 270 000 units of porcine factor VIII were given without any appreciable rise in the titre of antibodies to this agent or an increased tendency towards side effects.Though a prolonged conservative approach to management of a pseudotumour may be successful, it was clearly failing in this patient.The new porcine factor enabled us to overcome the problem of achieving and maintaining haemostasis during and after major surgery.We thank Professor R B Duthie and Dr C Rizza for permission to report on their patient
LEPER COLONY IN BRITISH COLUMBIA.
Journal: JAMA (1891)

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External validation of hepatic estimated steatosis index using magnetic resonance image
Authors: Dong Hwi Rim, Dae Won Jun, Jinhwa Park, Dong Hee Koh, Eun Chul Jang, Eileen Yoon, Jae Yoon Jeong, Sang Bong Ahn, Hyo Young Lee, Yong Kyun Cho, Bo-Kyeong Kang, Mi Mi Kim
Journal: Journal of Hepatology (2020)
Candida and Candidiasis
Authors: Claire L. Taschdjian
Journal: JAMA (1971)

<h3>To the Editor.—</h3> The EDITORIAL "Candidiasis: Colonization vs Infection" (<b>215</b>:285-286, 1971) presented the clinician's dilemma but few clues to its resolution. It quoted Ellis and Spivack's 12 cases of repeated candidemia and noted that six cases came to autopsy. Two cases were considered to be preterminal candidemia, in which no lesions were found at autopsy. Four cases showed widespread major organ candidiasis. Six patients got "well," two with the aid of antifungal therapy. The absence of a fatality in these six cases does not disprove the presence of candidal infection. Major organ disease in four out of 12 cases with persistent candidemia should give serious pause to any clinician. The review of Toala et al (<i>Arch Intern Med</i><b>126</b>:983, 1970) on the lack of significance of 371<i>Candida</i>isolates from specimens submitted for bacteriological examination leads only to more befuddlement. Although<i>Candida</i>from any specimen should not be
PNEUMOCOCCUS ULCERATION OF THE STOMACH.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Smile and Say "Cheese"
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
为什么银屑病患者锻炼不足？
Journal: British Journal of Dermatology (2020)

银屑病是一种慢性皮肤病，可导致鳞屑状斑块。约 2% 的人群受其困扰。银屑病患者比其他人更容易患心血管疾病（例如，心脏病或脑卒中）。众所周知，定期体育锻炼可降低心血管疾病的风险，但是令人担忧的是，银屑病患者的运动量少于大多数人。
Goodman and Gilman's The Pharmacological Basis of Therapeutics
Authors: Robert C. Hastings
Journal: JAMA (1996)

Pharmacology-Therapeutics As I remarked when I had the privilege of reviewing the last edition of this textbook for this journal, being asked to review<i>Goodman and Gilman's The Pharmacological Basis of Therapeutics</i>is a lot like being asked to comment on motherhood. "<i>G &amp; G</i>," the Blue Bible of pharmacology (the jacket is an even darker blue than the last edition) is the gold standard and has been for over 50 years. The preface informs us that the new ninth edition "is the first edition of this book that has not been painstakingly edited, word for word, by a member of the Goodman or Gilman family." In keeping with the exploding body of information in pharmacology and biomedicine in general, the textbook contains new subject headings, current information on newer drugs, and even new fields of information compared with the last edition. The eighth edition had four editors; the present
Human disease caused by Brucella canis. A clinical and epidemiologic study of two cases
Authors: R. S. Munford
Journal: JAMA (1975)

Nonlaboratory-associated human illness caused by<i>Brucella canis</i>occurred in two persons. Fever, chills, malaise, and weight loss were prominent symptoms in both patients. Epidemiologic investigation identified a household dog as the likely source of one patient's infection, and serologic studies and blood cultures on neighborhood dogs showed that approximately 30% were positive for<i>B canis</i>. Persons exposed to infected dogs appeared to have a low risk of disease. Although routine<i>Brucella</i>agglutinin tests do not detect antibodies to<i>B canis</i>, available methods for diagnosis include a specific<i>B canis</i>serologic test and culture techniques. (<i>JAMA</i>231:1267-1269, 1975)
Basic and Clinical Immunology
Authors: Paul P. VanArsdel
Journal: JAMA (1982)

When this book first appeared in 1976, the editors stated in the preface their intent to offer new editions biennially. They have done so, and done so very well. The new edition is the result of the most extensive revision yet. There are now three sections instead of the previous four. The first section, "Basic Immunology," now includes also what had been a separate second section in previous editions, "Immunobiology." The last two sections, "Immunologic Laboratory Tests" and "Clinical Immunology," are the same as before. Most of the major changes are found in the first section. New chapters have been added, "The Gene Organization and Assembly of Immunoglobulins," "Chemotaxis and Effector Functions of Macrophages and Granulocytes," and "Reproductive Immunology." The chapters on immune mechanisms in tissue damage and on the effect of sex hormones, nutrition, and aging on the immune response have been substantially expanded in scope from previous editions.
Relationship between summertime ambient ozone levels and emergency department visits for asthma in central New Jersey.
Authors: C P Weisel, R P Cody, P J Lioy
Journal: Environmental Health Perspectives (1995)

The 5-year retrospective study of the association between temperature and emergency department (ED) visits for asthma with mean ambient ozone levels between 10:00 and 15:00 was conducted in central New Jersey during the summer months. An association was identified in each of the years (1986-1990). Between 8 and 34% of the total variance in ED visits for asthma was explained by the two environmental variables in the step-wise multiple regression analysis. ED visits occurred 28% more frequently when the mean ozone levels were > 0.06 ppm than when they were < 0.06 ppm. This result was statistically significant in a covariance analysis. An evaluation of the effects of ozone on asthmatics reported in the literature was completed to determine if, as proposed by Bates, the results from different types of studies were coherent among the health metrics. A consistency in the magnitude of reported effects and the time lag between exposure and response for four different health indices (symptom reports, decrements in expiratory flow, ED visits, and hospital admissions) was identified and indicates a coherence between ozone and respiratory response to ozone exposure. This supports a proposition that ozone adversely affects asthmatics at levels below the current U.S. standard.
Influence of Food-Environment Interactions on Health in the Twenty-First Century
Authors: Owen Fennema
Journal: Environmental Health Perspectives (1990)

The quality and safety of foods are affected by the environment, and the quality and safety of the environment are, in turn, affected by foods and food processing. To explore these interrelationships, as they might exist in the twenty-first century, one must speculate regarding future changes in foods and food processing. Several trends in food processing seem likely to predominate into the twenty-first century, and they will be, for the most part, evolutionary in nature and of low consumer visibility. These trends are greater use of foods marketed in a refrigerated state, greater use of irradiation and combination processes, greater automation and optimization of processes, and greater use of biotechnology. It is also reasonable to assume that food products of the following types will increase in importance, namely, those that are convenient (includes eating away from home), those that are tailored to specific dietary needs, those containing chemically modified components such as altered proteins and carbohydrates, and fabricated foods. If these trends in foods and food processes prevail then concern must be directed to the following areas: Microbiological concerns--refrigerated foods; food service operations; new or altered procedures for processing, handling and storing foods; and new foods or food formulations; attention must be given both to controlling known pathogens as well as newly perceived pathogens. Chemical concerns--toxicants occurring naturally in foods; contaminants; chemicals developing in foods during processing, handling and storage; chemicals used in fabricated foods; and chemicals of newly perceived importance, especially those having adverse, covert effects. Several of these chemical concerns are influenced in seriousness by composition of the food environment.
Orthopedics
Authors: John Schwappach
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Techniques courantes de chimie clinique: Urine, liquide céphalo-rachidien sang, chimisme gastrique, bile, fèces.
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The ecologic method in the study of environmental health. I. Overview of the method.
Authors: S D Walter
Journal: Environmental Health Perspectives (1991)

This paper summarizes the salient features of the ecologic method, with emphasis on its application in the study of environmental health. Various types of ecologic design are described, with examples. Finally, the main advantages and disadvantages are indicated. A companion paper discusses the methodology of ecologic designs in more detail and describes a census of data sets with potential suitability for the ecologic study of water quality and human health.