tbuckley/cabot-search huggingface dataset:
Acute Poisoning with Chlorpromazine
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 3863: Specifically targeting PDIA1 with indene inhibitors leads to bortezomib-potentiation in multiple myeloma
Authors: Reeder M. Robinson, Leticia Reyes, Ravyn Duncan, Nathan Dolloff
Journal: Cancer Research (2019)

Abstract Protein disulfide isomerase (PDI) is an emerging therapeutic target in oncology. PDI inhibitors have demonstrated a unique propensity to overcome resistance to existing cancer therapies, although drug candidates have not yet progressed to the stage of clinical development. We recently reported the discovery of lead indene compound E64FC26 as a potent pan-PDI inhibitor that enhances the cytotoxic effects of proteasome inhibitors (PIs) in panels of Multiple Myeloma (MM) cells and MM mouse models [1]. An extensive medicinal chemistry program has led to the generation of a diverse library of indene-containing molecules with varying degrees of PI-potentiating activity. The results show detailed structure activity relationships (SAR) with a high degree of correlation between potency of PDIA1 inhibition and bortezomib (Btz) potentiation in MM cells. Inhibition of PDIA1 in MM leads to ER and oxidative stress characterized by the accumulation of misfolded poly-ubiquitinated proteins and the induction of UPR biomarkers ATF4, CHOP, and Nrf2. Furthermore, an advanced derivative, E64FC65, was identified as a PDIA1 selective inhibitor as it was significantly weaker against PDIA3, PDIA4, TXNDC5, PDIA6, and thioredoxin when compared to E64FC26 (Table 1). We purified the redox-active a and a’ thioredoxin-like domains of PDI and found that E64FC65 only inhibited the a domain while E64FC26 inhibited both a and a’ domains. The PDI isoform and domain selectivity of E64FC65 imparted increased anti-cancer activity while reducing toxicity against primary activated human T-cells. Additionally, E64FC65 exhibited improved pharmaceutical properties in ADME assays. This work shows the generation of a PDIA1 a domain specific indene inhibitor that potentiates Btz cytotoxicity in MM cells while abrogating toxicity in normal cells. E64FC65 is thus a favorable PDI inhibitor candidate for further development. Citation Format: Reeder M. Robinson, Leticia Reyes, Ravyn Duncan, Nathan Dolloff. Specifically targeting PDIA1 with indene inhibitors leads to bortezomib-potentiation in multiple myeloma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3863.
Social policy considerations in noncoital reproduction
Authors: S. Elias
Journal: JAMA (1986)

NOW THAT 1984 has come and gone, Huxley's vision of our future in<i>Brave New World</i>looms larger than Orwell's. Huxley envisioned the abolition of parenthood and the family, which would take place with the full cooperation of society as it attempted to improve on natural reproduction. We are on our way toward Huxley's vision, and 1984 saw significant scientific and societal developments in noncoital human reproduction and corresponding steps to redefine parenthood and family relationships. On the scientific side, the year saw the first birth from surrogate embryo transfer (SET)<sup>1</sup>and the first birth from a frozen embryo (<i>New York Times</i>, April 11, 1984, p A16). On the societal side, the year saw major reports by government-appointed panels on noncoital reproduction in the United Kingdom (the Warnock Report)<sup>2</sup>and Australia (the Waller Report)<sup>3</sup>and Congressional hearings on the subject in the United States.<sup>4</sup> Techniques for
Hepatic Toxicity Possibly Associated With Kava-Containing Products—United States, Germany, and Switzerland, 1999-2002
Journal: JAMA (2003)

Since 1999, health-care professionals in Germany, Switzerland, and the United States have reported the occurrence of severe hepatic toxicity possibly associated with the consumption of products containing kava (i.e., kava kava or Piper methysticum). A total of 11 patients who used kava products had liver failure and underwent subsequent liver transplantation. On March 25, 2002, in response to five such case reports (four in Europe and one in the United States), the Food and Drug Administration (FDA) issued a consumer advisory and subsequently completed an investigation already underway of a similar U.S. case. This report presents the investigation of the two U.S. cases of liver failure associated with kava-containing dietary supplement products and summarizes the European cases. FDA continues to advise consumers and health-care providers about the potential risk associated with the use of kava-containing products.
Lymph Node Examination Rate, Survival Rate, and Quality of Care in Colon Cancer
Authors: Elke Peters
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Video Terminal—Light-Pen Device For Ordering Medical Tests
Authors: Robert G. Siekert
Journal: JAMA (1968)

In order for a physician to obtain the advantage of an automated laboratory ordering and reporting system, he must have easy access to the system. The access device or technique should be easy to use and should require no new skills. A television screen with a light-pen pointer was found acceptable. Furthermore, the laboratory tests may be organized in several ways, enabling the user to order appropriate clusters of tests.
<i>In vivo</i> confocal microscopy of multiple myeloma associated crystalline keratopathy
Authors: Caleb Busch, Shizuka Koh, Yoshinori Oie, Michiko Ichii, Yuzuru Kanakura, Kohji Nishida
Journal: American Journal of Hematology (2018)

Am J Hematol. 2017;92:593–594 - DOI 10.1002/ajh.24692 First published: 21 February 2017 We have a correction on the woman's age to the first sentence (incorrect) 81 (correct) 75. Correction: An 75-year-old Japanese woman, who had been diagnosed 5 years previously with smoldering multiple myeloma, was referred to the ophthalmology department for blurry vision.
Poetry and Medicine
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Evaluation of microcrystalline griseofulvin therapy in tinea capitis
Authors: N. Zaias
Journal: JAMA (1966)

Three hundred twenty-four cases of scalp ringworm among Negro school children were studied in Miami, Fla. Approximately one half of these were nonfluorescent infections due to<i>Trichophyton tonsurans</i>, the remainder being fluorescent<i>Microsporum</i>infections, of which one in every four cases was due to<i>M rivalieri</i>, a newly described African species closely related to<i>M audouinii</i>. In the<i>T tonsurans</i>infections, neither a single 3-gm dose of microcrystalline griseofulvin nor four 1-gm doses at weekly intervals was considered effective therapy. Daily doses of griseofulvin are recommended for the treatment of nonfluorescent tinea capitis. In contrast, a single 3-gm dose plus a topically applied benzoic and salicylic acid (Whitfield's) ointment was curative in 88% of the<i>Microsporum</i>infections. Attention is again drawn to the increasing incidence of nonfluorescent<i>Trichophyton</i>infections of the scalp in the United States.
AUTHORS' REPLY
Authors: G Nierop, E. Bel, J. Dijkman
Journal: Thorax (1992)

Auranofin in steroid dependent asthmaWe read with interest the article by Dr Nierop and others (May 1992;47:349-54) concerning oral gold in the treatment of steroid dependent asthma.We were surprised to notice that most patients did not receive maximal high dose inhaled corticosteroids when included in the study; this was the case with nine patients in the placebo group (69%) and eight patients in the auranofin group (53%).This must be pointed out as high dose inhaled corticosteroids (that is, beclometha- sone 1500-2000 pg/day or budesonide 1200- 1600 pg/day) are known to be more effective
Home device for breast cancer detection?
Authors: J. Henahan
Journal: JAMA (1982)

An experimental breast cancer screening device intended for home use is reported to have picked up mammary tumors as small as 2 mm in diameter in asymptomatic women. "This is way before [two to ten years] the tumor becomes palpable or visualizable by mammogram," said cardiologist Harold L. Karpman, MD, associate clinical professor of medicine at the UCLA School of Medicine. He spoke at the Third International Congress of Thermology in Bath, England. The "Breast Cancer Screening Indicator" he described is composed of two plastic disks containing heat-sensitive chemicals that are worn inside a woman's brassiere for 15 minutes each month so she can observe color changes that could indicate a breast abnormality. In 179 symptomatic women who used the device under supervision of clinicians at Memorial Sloan-Kettering Cancer Center in New York, MD Anderson Hospital in Houston, Brotman Memorial Hospital in Los Angeles, and UCLA, 74 of 84 unilateral
2010 ACCF/AHA/AATS/ACR/ASA/SCA/SCAI/SIR/STS/SVM Guidelines for the Diagnosis and Management of Patients With Thoracic Aortic Disease: Executive Summary
Authors: Loren F. Hiratzka, George L. Bakris, Joshua A. Beckman, Robert M. Bersin, Vincent F. Carr, Donald E. Casey, Kim A. Eagle, Luke K. Hermann, Eric M. Isselbacher, Ella A. Kazerooni, Nicholas T. Kouchoukos, Bruce W. Lytle, Dianna M. Milewicz, David L. Reich, Souvik Sen, Julie A. Shinn, Lars G. Svensson, David M. Williams
Journal: Circulation (2010)
ACRIFLAVINE BASE IN VENEREAL PROPHYLAXIS
Journal: JAMA (1929)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Is it all right for women to drink small amounts of alcohol in pregnancy?
Authors: Pat O'Brien, Vivienne Nathanson, Nicky Jayesinghe, George Roycroft
Journal: BMJ (2008)

The National Institute for Health and Clinical Excellence draft guidance on drinking during pregnancy has added to confusion about safety. <b>Pat O9Brien</b> believes that telling women to abstain is overly paternalistic on current evidence, but <b>Vivienne Nathanson</b><b>and</b><b>colleagues</b> argue that this is the safest message
Bromocriptine induced psychosis in acromegaly.
Journal: BMJ (1983)

important match is unjustified when they are led to believe that the team is more important than the individual.These attitudes need urgent reappraisal.In May 1979 the Medical Officers of Schools Association issued a series of guidelines in an attempt to prevent or reduce the number of injuries.8In response the Rugby Football Union began collecting information about the number of neck injuries sustained in school matches with a view to publishing a definitive statement.6An accurate and definitive statement is long overdue on what has been a recognised problem for some time.The registration of all such injuries by schools and rugby clubs should be made com- pulsory and rigorously maintained by the Rugby Football Union or a similar responsible central body.This should include a description of the incident; the player's age, weight, and height; and, after consultation with an orthopaedic surgeon, details of the injury sustained.Meanwhile, the onus is on players to refrain from foul play and illegal tactics and on referees to be aware continually of the risks, to control the game, and to penalise the players appropriately.We hope that the spectacle of wheelchair bound, paraplegic, former rugby players being lined up to be greeted by their more fortunate colleagues will not be perpetuated.
THE MEAT-PREPARING INDUSTRY IN SOUTH AMERICA
Journal: BMJ (1930)

MF;)nTI sri81 at the Middlesex Hospital was that tlhe, stanidai,d of kntow- ledlge 'of these first-year stude6ntts w-as inferior to that reaached by tlose wlho begail to study tlhe preliminiary Scielnces in their owni medical sellool.ANNUAL D-u.The annl-ual (llin]ler of past aid present students was held in the eveningg of thie samie day at the Savoy Hotel, un1der the clhairm ofanshmips of Dr. r .E. LAKIN, physiciani to the hospital.In proposing tlhe.toast of " Prosrerity to the Middlesex Hospital anid Medical School," tlle-clhairmiiani expressed regret at the absence of Prince Artlhur of C'on11na11g11ht, who was presidinig that evening over-the .Guildhall banquet to oversea Premiers.He said that the reconstruetioq of the hospital ra's goinlg forward very well imideed.More than two-t}hird-s of the building programme was finished and paid for, twro-thir ds of the, £1,100,000 asked for havini-g already been collected.Whenl this great sem-}eLa1e w:-as completed they would hiave a miioderni hospital Df nearly 700 beds.More than a quarter of a miillioin was t ill nieeded to pay for the last section, bUt he did iiot (dOlbt thIat it would be forthcoming.The toast was responded to
The temporomandibular syndrome
Authors: C. S. Greene
Journal: JAMA (1973)

Patients with facial pain frequently consult physicians or dentists, or both, about their problems. Sometimes the diagnosis can be made easily, as in cases of obvious otitis, sinusitis, or dental abscess. Other conditions, however, can be considerably more difficult to identify or to manage. One such condition is the temporomandibular joint (TMJ) pain-dysfunction syndrome, which has been described extensively in the medical and dental literature over the past 40 years. Yet, a recent survey published in the<i>Journal of the American Dental Association</i><sup>1</sup>showed that many physicians and dentists still are either uninformed about the syndrome, or they are following outdated concepts of diagnosis and treatment for TMJ problems. In fact, a substantial number of practitioners in both professions did not even acknowledge the existence of a TMJ pain-dysfunction syndrome. In the survey, which included a random group of physicians and a sampling of members of the American Association
Communication Gaps Hinder Full Recovery From Depression
Authors: R. Voelker
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Intravenous Arginine-Vasopressin in Children With Vasodilatory Shock After Cardiac Surgery
Authors: Erika Berman Rosenzweig, Thomas J. Starc, Jonathan M. Chen, Suzanne Cullinane, Donna M. Timchak, Welton M. Gersony, Donald W. Landry, Mark E. Galantowicz
Journal: Circulation (1999)

Background —Recent investigations at our institution have studied a variety of vasodilatory shock states that are characterized by vasopressin deficiency and pressor hypersensitivity to the exogenous hormone. Our experience in adults prompted the use of arginine-vasopressin (AVP) in a similar group of critically ill children. Methods and Results —This report describes our early experience (from February 1997 through April 1998) in 11 profoundly ill infants and children (5 male, 6 female) ages 3 days to 15 years (median, 35 days) treated with AVP for hypotension after cardiac surgery which was refractory to standard cardiopressors. Although underlying heart disease was present (congenital heart defects in 10 and dilated cardiomyopathy in 1), only 2 patients had severely depressed cardiac function as demonstrated by 2D echocardiogram before administration of AVP. All patients were intubated and receiving multiple catecholamine pressors and inotropes, including dobutamine (n=10), epinephrine (n=8), milrinone (n=7), and dopamine (n=4) before receiving AVP. Five patients received AVP intraoperatively immediately after cardiopulmonary bypass, 5 in the intensive care unit within 12 hours of surgery, and 1 on postoperative day 2 for hypotension associated with sepsis. The dose of AVP was adjusted for patient size and ranged from 0.0003 to 0.002 U · kg −1 · min −1 . During the first hour of treatment with AVP, systolic blood pressure rose from 65±14 to 87±17 mm Hg ( P &lt;0.0001; n=11), and epinephrine administration was decreased in 5 of 8 patients and increased in 1. Plasma AVP levels before treatment were available in 3 patients and demonstrated AVP depletion (median, 4.4 pg/mL; n=3). All 9 children with vasodilatory shock survived their intensive care unit stay. The 2 patients who received AVP in the setting of poor cardiac function died, despite transient improvement in blood pressure. Conclusions —Infants and children with low blood pressure and adequate cardiac function after cardiac surgery respond to the pressor action of exogenous AVP. AVP deficiency may contribute to this hypotensive condition.
&lt;TITLE&gt;Giving life&lt;/TITLE&gt;
Authors: Mi Hwang
Journal: JAMA (1998)

common point of self-reflection is whether we have truly accomplished anything worthwhile during our lifetime.One way to ensure that you leave a lasting legacy that could help save other people's lives is to become an organ and tissue donor.There are almost 58,000 Americans on a national waiting list to receive organ transplants.However, fewer than 5,500 organs were retrieved after donors' deaths last year.That means thousands of people who need organs die each year because organs are not available.In addition, there are currently approximately 3 million Americans who have received new skin for their burns, new corneas to help them see, or new bones, among other things, through tissue transplants.Studies, such as a current one by the United Network for Organ Sharing in the October 7, 1998, issue of JAMA, show that more people over the last decade have been able to live longer after receiving an organ transplant.The researchers report that there are more transplant programs today, more transplants being performed, and longer survival rates for all organs.
DIABETES MELLITUS*
Authors: J. VALLANCE-OWEN
Journal: British Journal of Dermatology (1969)

Journal Article DIABETES MELLITUS Get access J. VALLANCE‐OWEN J. VALLANCE‐OWEN Department of Medicine, Queen's University, Belfast, Northern Ireland Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 81, Issue s2, 1 March 1969, Pages 9–13, https://doi.org/10.1111/j.1365-2133.1969.tb12839.x Published: 01 March 1969