tbuckley/cabot-search huggingface dataset:
Abstract B39: Osteosarcoma cells interact with bronchial cells in lung to drive production of prometastatic cytokines
Authors: John Hinckley, Amy Gross, Ryan Roberts
Journal: Cancer Research (2018)

Abstract The survival rate for patients diagnosed with osteosarcoma (OS) drops from 70% to an abysmal 20% when diagnosed with lung metastasis. We have shown that metastatic colonization of lungs by OS cells depends on the production of IL6 and CXCL8 by tumor cells, which seems to increase within the metastatic niche of the lung. Identification of key tumor-host interactions that drive this phenomenon will facilitate the development of novel therapies aimed at prevention of metastases in patients diagnosed with OS. We hypothesized that OS cells interact with lung tissues in ways that establish paracrine signal amplification loops, where IL6 and CXCL8 stimulate lung-resident cells to produce secondary signaling molecules that, in turn, stimulate tumor cell production of IL6 and CXCL8 in a feed-forward mechanism. Coculture experiments identified strong interactions between OS cells and primary cultures of bronchial epithelial cells and lung smooth muscle cells. Exposure of OS cells to conditioned supernatants from the primary cell cultures and vice versa showed that these interactions result from exchange of soluble mediators secreted by each cell type. Proteomic profiling of the resultant supernatants identifies a number of interesting candidate mediators, which might also affect the growth and survival of OS cells within the microenviroment of the lung. These results suggest a mechanism for the establishment of a metastatic niche favorable to OS cells within lung tissues. Citation Format: John Hinckley, Amy Gross, Ryan Roberts. Osteosarcoma cells interact with bronchial cells in lung to drive production of prometastatic cytokines [abstract]. In: Proceedings of the AACR Special Conference: Pediatric Cancer Research: From Basic Science to the Clinic; 2017 Dec 3-6; Atlanta, Georgia. Philadelphia (PA): AACR; Cancer Res 2018;78(19 Suppl):Abstract nr B39.
HLA class II genes in chronic hepatitis C virus-infection and associated immunological disorders
Authors: M Congia
Journal: Hepatology (1996)

To investigate the factors that may confer susceptibility or protection to hepatitis C virus (HCV) infection and to HCV-associated immunological disorders, we designed two studies on 420 Sardinian transfusion-dependent thalassemia patients followed in our department in Cagliari since 1974. The first one was an epidemiological survey aimed to evaluate the prevalence of HCV infection and HCV-associated immunological disorders. In the second study, the distribution of different HLA class II genes was examined by DNA analysis in 116 HCV positive patients, 30 HCV negative patients, and 606 healthy controls. Three hundred fourteen patients became infected with HCV (74.7%) after 5.6 ± 2.8 years of regular transfusion program. Mixed cryoglobulinemia, purpura, arthritis, proteinuria, decreased complement levels, rheumatoid factor and anti-GOR, smooth muscle antibody (SMA), anti-nuclear antibody (ANA), and liver, kidney microsome (LKM) autoantibodies were significantly more represented in HCV positive patients than in negative ones (P < .05). A significant increase of HLA class II DR2 subtype (DRB1*1601,DQB1*0502) was observed in a group of 30 HCV negative patients who despite 10.3 ± 2.2 years in a regular blood transfusion program did not show any evidence of HCV infection (Pc < .0092). Our results represent clear evidence for a relationship between HCV infection and immune extrahepatic abnormalities. A gene(s) located in the human major histocompatibility complex (MHC) region may play an important role in conferring protection against HCV infection.
Hydromediastinum
Authors: R. Adar
Journal: JAMA (1970)

<h3>To the Editor.—</h3> Complications resulting from puncture and catheterization of the subclavian vein so far reported have been mainly of two types: (1) injury to surrounding structures (subclavian artery or other vessels, apical pleura, brachial plexus) or the subclavian vein itself by the needle advancing towards the vein or beyond it, or (2) complications due to the presence of a needle or a catheter in the subclavian vein, such as air embolism, phlebitis, septicemia, and catheter embolism. A different type of complication is reported here. <h3>Report of a Case.—</h3> A 73-year-old male patient underwent resection of a segment of terminal ileum because of small-bowel occlusion due to a healed ischemic lesion. A postoperative x-ray film of the chest appeared normal except for a linear atelectasis in the right lower lung field. Six days later, a breakdown of the anastomosis was treated by another resection. Before the second operation could be
Dr. Robert L. Faulkner Is Not Dead
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
EHPnet: National Center for Human Genome Research
Journal: Environmental Health Perspectives (1996)

American Free Trade Agreement created the Border Environment Cooperation Commission (BECC) to oversee pollution reduction of all kinds-air, water, and solid waste.Groups working specifically on the brickmaking problem include the Environ- mental Defense Fund (EDF), Physicians for Social Responsibility, the Federacion Mexicana de Asociaciones Privadas de Salud y Desarrollo Comunitario (FEMAP), and El Paso Natural Gas (EPNG).FEMAP and EPNG started a brickmaking school to teach the ladrilleros how to use higher quality fuel.According to EPNG vice president John Somerhalder, the school also helps the brickmakers with safety and business practices as well."A huge number of brickmakers, not only from Juarez but from all over Mexico, have been through that school," Somerhalder says.For a time, brickmakers were able to use liquefied petroleum gas (LPG), also known as butane.But in 1994 the Mexican government began to phase out its subsidy of LPG.Around the same time, the peso was also devalued.Consequently, the cost of LPG rose steeply.The brick- makers reverted to the cheaper fuels, espe- cially at night, despite the fact that the Mexican government has made it illegal to burn tires.A combined amelioration effort by EPNG and New Mexico's Los Alamos National Laboratory (LANL) has shown strong promise.LANL materials scientists Karl Staudhammer and Charles Grigsby experimented with kiln design to improve fuel efficiency."The big problem is nonuni- formity of temperature," Staudhammer says.The LANL design entails building sev- eral kilns near each other and transferring the heat that is lost during the firing of one kiln to the next one.Computer modeling enabled Staudhammer and Grigsby to design a furnace that uses 60% less gas.Somerhalder emphasizes that "as in all environmental problems, there's usually a solution; it's just a very expensive solution."Because the colonias are not equipped with natural gas lines and the cost of LPG remains high, the conversion and increased-efficiency approaches to the problem have limited effectiveness."It's a classic case of balancing the social and economic and environmental con- cerns," Somerhalder says.It would be easy, he says, to impose a strictly envi- ronmental solution from the top down by banning all dirty fuels, but the brickmakers of Mexico would probably be driven out of business altogether.
RECENT WORK ON CELL POISON OF ANIMAL ORIGIN.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Feasibility of robot-assisted radical prostatectomy in elderly patients: Comparative analysis of the peri-surgical/oncological outcomes with younger patients.
Authors: Takehiro Iwata, Takashi Saika, Kohei Edamura
Journal: Journal of Clinical Oncology (2016)

134 Background: Robot-assisted radical prostatectomy (RARP) has become one of standard treatments for localized prostate cancer. However, a feasibility of RARP in elderly patients has not been clear yet. We performed a comparative analysis of peri-surgical/oncological outcomes for younger and elderly patients underwent RARP. Methods: We reviewed and compared our initial 340 consecutive patients who underwent RARP from 9/2012 to 8/2015 for peri-surgical outcomes, including surgical times, blood loss, complications, pathological findings, continence recovery, and oncological outcomes stratified by age less than 70 and over 70 years. Results: In our cohort, 202 men were age less than 70 and 138 men were ≥70. Preoperative parameters (age, PSA, Gleason score) were similar in both younger and elder groups. Operative time (median: 167 vs. 171 minutes) and estimated blood loss were similar in both groups. One of elder patients (0.7%) needed transfusion. Peri/post-operative complications in both groups appeared to be minimal with no cases of intra-operative open conversion. One of younger patients needed a surgical settlement for port site herniation. Surgical positive margin rates in organ-confined (pT2) disease were also similar (5.6%, younger vs. 9.0%,elder). Continence at 3 months was 82% in elder patients as opposed to 87% in younger patients. Median follow-up period in in elder patients and younger patients were 15.2 and 15.3 months, respectively. Biochemical recurrence free survival rates in elder patients and younger patients were 89.9% and 93.6%, respectively (p=0.1026). Conclusions: In our study, RARP in elderly patients was relatively safe and yielded good oncologic results. RARP is feasible even in elderly patients.
Nazi Medicine
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BACTERIAL VACCINE THERAPY: ITS INDICATINS AND LIMITATIONS
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cancer Among Nuclear Test Participants-Reply
Authors: Glyn G. Caldwell
Journal: JAMA (1984)

<h3>In Reply.—</h3> We agree with Dr Gross that experimental evidence in animals and data from human populations exposed to 150 to 200 rad of ionizing radiation suggest that they experienced an increased incidence of leukemia and solid tumors, but we have no data indicating that the nuclear test participants at Smoky were exposed to that level of radiation. Furthermore, the data from studies on populations exposed to ionizing radiation in the 150- to 200-rad range have shown some solid tumors after 15 to 20 years. We do not doubt that susceptibility differs by host and organ system, since that too has been found in irradiated human populations. We have no quarrel with the theory that some synergistic response may have occurred with an unknown virus, a genetically susceptible host, or with prior or subsequent chemical or radiation exposure. We simply lack the data to ascertain if these responses could account
DDT/DDE and Infant Exposure
Authors: Koenraad Mariën
Journal: Environmental Health Perspectives (1997)

DDT/DDE and Infant ExposureThe article by L6pez-Carrillo et al. (1), which discusses the public health implica- tions of using DDT in Mexico, is a wel- come contribution to the literature.DDT is a public health concern not only in the countries still using the chemical but also in those countries that have restricted, phased out, or banned use of the chemical.Presently, it is difficult to conclude if DDT contributes to breast cancer incidence, and the lack of complete confidence in our understanding of the relationship between this xenoestrogen and breast cancer should not prevent us from finding alternatives to DDT that have less public health impact.L6pez-Carrillo et al. (1) base their concern for DDT primarily on the possible increase of breast cancer with exposure.Although this endpoint is of concern, toxicological endpoints that deserve equal attention pertain to infant exposure.Teratology studies by Eriksson et al.
Topical agents for the skin: efficacy and safety.
Journal: BMJ (1985)

Topical agents for the skin: efficacy and safety CSM Update is a regular monthly column written by members and staffofthe Committee on Safety ofMedicines to explain and discuss the committee's role in licensing drugs and monitoring adverse effects.Like systemic agents, new topical preparations have to satisfy requirements for efficacy and safety to comply with government licensing regulations.Applying these criteria to the skin presents special problems.
The Reorganization of the Harlem Hospital of New York.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Compend of Diseases of the Skin.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ENDOCRINE DWARFISM
Authors: WILLIAM ENGELBACH
Journal: JAMA (1934)

The problem of diagnosis and treatment of statural undergrowth, or dwarfism, rightfully belongs to the general practitioner and pediatrician. One has but to study the normal growth increment curve in the human being for this proof. It testifies to the fact that approximately 50 per cent of the total growth has been attained at the age of 3 years. Its increasing plateau diminishes rapidly as adolescence or sex maturity is attained. It logically follows that diagnosis and adequate treatment during the infantile and early juvenile periods should give greater therapeutic results. There is an abundance of experimental evidence that the factor concerned in somatic growth is produced by the eosinophilic cell of the anterior lobe of the hypophysis. By this is meant that every structure of the body, from an individual cell to the constitutional whole, is involved. The three postulates of hormonology, the therapeutic side of endocrinology, are completely
Reflux nephropathy
Authors: S. Vaisrub
Journal: JAMA (1981)

Although ureterovesical reflux in children was described as early as 1897,<sup>1</sup>and the glomerular changes that often ensue if these children survive to adulthood were noted half a century ago,<sup>2</sup>reflux nephropathy—a term embracing both the etiology and the sequel—is still incompletely understood. Currently, however, with opportunities provided by improved histological and histoimmunologic techniques, this condition is undergoing extensive investigation. Two recent studies—one from Lexington, Ky,<sup>3</sup>the other from the Mayo Clinic<sup>4</sup>—shed more light on the development of reflux nephropathy and its response to renal transplantation. Their conclusions are not always in accord. Bhatena et al<sup>3</sup>of the Lexington group studied 23 patients with reflux nephropathy between 1973 and 1977. All 23 underwent nephrectomies with subsequent renal transplantation, and all manifested focal and segmental glomerulosclerosis in their native kidneys. The lesions appeared to evolve from early glomerular hypertrophy to focal and segmental and occasionally
Forced Respiration.
Authors: A. W. Herzog
Journal: JAMA (1891)

<h3>To the Editor:</h3> —In a recent number ofThe JournalI find an address by Dr. G. E. Fell, on " Forced Respiration." Allow me to draw your attention to an article which appeared in the year 1822, and which may possibly be of interest to the medical fraternity. I am in possession of the<i>London Journal of Arts and Sciences</i>, Vol. 3, London, 1822, page 93: "Account of an apparatus for restoring the lost action of the lungs, in consequence of suspended animation from drowning, etc.; invented and communicated by John Murray, Esq." There is, perhaps, no subject which ought to excite a deeper interest, than that of suspended animation. The number of human beings who are hurried suddenly out of existence, by being deprived of that necessary pabulum, atmospheric air, form annually a lamentable catalogue; and, although a Goodwin, a Hawes, a Cogan, and many others of the benevolent