tbuckley/cabot-search huggingface dataset:
Traité de physiologie; normale et pathologique. Par G.-H. Roger, professeur de physiologie à la Faculté de médecine de Paris. Tome VIII: Physiologie musculaire. Chaleur animale.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Subcutaneous and Visceral Adipose Tissue: Their Relation to the Metabolic Syndrome
Authors: B. L. Wajchenberg
Journal: Endocrine Reviews (2000)

Methods for assessment, e.g., anthropometric indicators and imaging techniques, of several phenotypes of human obesity, with special reference to abdominal fat content, have been evaluated. The correlation of fat distribution with age, gender, total body fat, energy balance, adipose tissue lipoprotein lipase and lipolytic activity, adipose tissue receptors, and genetic characteristics are discussed. Several secreted or expressed factors in the adipocyte are evaluated in the context of fat tissue localization. The body fat distribution and the metabolic profile in nonobese and obese individuals is discussed relative to lipolysis, antilypolysis and lipogenesis, insulin sensitivity, and glucose, lipid, and protein metabolism. Finally, the endocrine regulation of abdominal visceral fat in comparison with the adipose tissue localized in other areas is presented.
569. Gene Therapy of Uterine Leiomyoma: Adenovirus-Mediated Herpes Simplex Virus Thymidine Kinase/Ganciclovir Treatment Inhibits Growth of Human and Rat Leiomyoma Cells In Vitro and in a Nude Mouse Model
Authors: Salama A. Salama, Marwa W. Kamel, Gregory M. Christman, Hui Q. Wang, Ayman A. Al-Hendy
Journal: Molecular Therapy (2006)

BACKGROUND: Leiomyomas (fibroids) are the most common uterine tumors that affect a high percentage of reproductive aged women. Lack of effective and safe non-surgical treatment is a challenge in the management of this disorder. Currently, hysterectomy remains the main stay treatment. However, this option is not alwaysappropriate or desirable treatment especially for women who want to preserve their fertility. Thus, the development of a safe, effective, non-surgical and localized method of treatment for uterine leiomyomas is an urgent need in women's health care.
King-Anderson Hearings and the `Sanctions' Charge
Journal: JAMA (1961)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
New, poorly recognized echocardiographic findings. Occurrence in patients with pericardial effusion
Authors: S. Zoneraich
Journal: JAMA (1976)

New, poorly recognized echocardiographic findings were recorded in six patients with pericardial effusion. These findings were apparent prolapse of mitral and tricuspid valves, apparent systolic anterior motion of mitral valve, and midsystolic notching of pulmonic valve. Beat-to-beat variation of the dimensions of right and left ventricle and in the diastolic opening amplitude of the anterior mitral valve were present in cardiac tamponade. Substantial decrease or resolution of effusion resulted in disappearance of the observed abnormalities. Serial echographic studies before and after fluid resolution may prevent misleading echographic and clinical diagnoses. (<i>JAMA</i>236:1954-1957, 1976)
SOAPS IN RELATION TO THEIR USE FOR HAND WASHING
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
High detection rate of T-cell receptor beta chain rearrangements in T-cell lymphoproliferations by family specific polymerase chain reaction in combination with the GeneScan technique and DNA sequencing
Authors: Chalid Assaf, Michael Hummel, Edgar Dippel, Sergij Goerdt, Hans-Henning Müller, Ioannis Anagnostopoulos, Constantin E. Orfanos, Harald Stein
Journal: Blood (2000)
The Association between Use of Certain Medicines and Cancer of the Esophagus
Journal: Annals of Internal Medicine (2000)

Summaries for Patients1 August 2000The Association between Use of Certain Medicines and Cancer of the EsophagusSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-133-3-200008010-00027 SectionsAboutFull Text ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?The esophagus is the tube that connects the mouth and the stomach. In recent years, the frequency of adenocarcinoma, one of the two main types of cancer of the esophagus, has been increasing while the frequency of squamous-cell cancer, the other type, has stayed the same. Gastroesophageal reflux, a condition in which stomach contents wash up into the esophagus, is thought to contribute to the development of adenocarcinoma of the esophagus. A muscle between the esophagus and stomach, known as the lower esophageal sphincter (LES), normally keeps stomach ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Association between Medications That Relax the Lower Esophageal Sphincter and Risk for Esophageal Adenocarcinoma” It is in the 1 August 2000 issue of Annals of Internal Medicine (volume 133, pages 165-175). The authors are J. Lagergren, R. Bergström, H.-O. Adami, and O. Nyrén.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAssociation between Medications That Relax the Lower Esophageal Sphincter and Risk for Esophageal Adenocarcinoma Jesper Lagergren , Reinhold Bergström , Hans-Olov Adami , and Olof Nyrén Metrics 1 August 2000Volume 133, Issue 3Page: 165KeywordsCardiaDrugsEsophageal adenocarcinomaEsophageal cancerEsophagusGastric cancerHeart diseasesLungsMusclesStomach ePublished: 15 August 2000 Issue Published: 1 August 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.Loading ...
Abstract 106: microRNA-33a Regulates Myocardin Expression and Attenuates Cardiac Remodeling in Renal Artery Ligation Model of Heart Failure
Authors: Madhu Khullar, Anupam Mittal, Santanu Rana, Rajni Sharma, Vikas Arige, Sanskriti Khanna, Nitish Mahapatra, Sagartirtha Sarkar, Uma N Saikia, Ajay Bahl
Journal: Circulation Research (2017)

Myocardin (MYOCD), a cardiac specific transcriptional co-activator is up-regulated in heart failure (HF). Up-regulation of MYOCD expression has been proposed to be an important adaptive response in cardiac remodelling. However, molecular mechanisms contributing to increased cardiac MYOCD expression in HF are not known. The goal of this study was to identify microRNA(s) regulating cardiac MYOCD expression and to study the effect of cardiac modulation of MYOCD specific miRNA in an animal model of HF. miRNA(s) targeting MYOCD were identified using in silico approach and validated by 3’-UTR luciferase reporter assay. Cardiac expression of miRNA was measured in endomyocardial biopsies from idiopathic DCM (IDCM) patients, renal artery ligation rat model of HF (RAL) and in Ang II treated cardiomyocytes by real-time PCR. miRNA-33a, miRNA-33b, miRNA-139 and miRNA-542 were identified with MYOCD as putative target. Cardiac expression of miRNA-33a and miRNA-33b was significantly decreased, whereas expression of miRNA-139 and miRNA-542 was not altered in IDCM. miRNA-33a expression was also decreased in RAL and in Ang II treated cardiomyocytes. Luciferase assay confirmed MYOCD as target gene for miRNA-33a. miRNA-33a overexpression significantly decreased expression of MYOCD, ANP and fibrotic genes in Ang II treated cardiomyocytes. Cardiac specific delivery of miRNA-33a, using a homing peptide conjugated siRNA, attenuated cardiac hypertrophy and fibrosis, decreased expression of ANP, β-MHC and fibrotic genes and ameliorated the impaired diastolic dysfunction in RAL. Our results provide the first evidence that miRNA-33a regulates MYOCD expression and cardiac specific augmentation of miRNA-33a attenuated cardiac remodelling and partially restored left ventricular function. Our results suggest miR-33a as a potential therapeutic target in reversal of cardiac remodelling and improvement in heart function in HF.
Cerebral Circulation: Effects of Sympathetic Nerves and Protective Mechanisms During Hypertension
Authors: Frank M. Faraci, William G. Mayhan, Andrew H. Werber, Donald D. Heistad
Journal: Circulation Research (1987)

The first goal of this study was to examine bilateral effects of reflex activation of sympathetic nerves on the cerebral circulation.Seizures, which activate sympathetic nerves, were induced in animals with intact nerves and after bilateral cervical sympathetic denervation.Increases in cerebral blood flow (microspheres) and decreases in cerebral vascular resistance were similar in denervated and innervated animals.Thus, during intense metabolic stimulation, metabolic factors are the primary determinant of cerebral blood flow, and bilateral effects of sympathetic nerves are minimal.The second goal of this study was to examine the role of vascular hypertrophy in protection of the cerebral circulation.Cerebral perfusion pressure was decreased on one side by clipping one carotid artery in 4-week-old stroke-prone spontaneously hypertensive rats.Two to four months later, the clip was removed, and seizures were induced.Disruption of the blood-brain barrier in the cerebrum occurred predominantly on the clipped side.We suggest that reduction in perfusion pressure attenuates development of cerebral vascular hypertrophy and thereby increases susceptibility to disruption of the blood-brain barrier.Thus, hypertrophy of cerebral vessels during chronic hypertension may protect the cerebral circulation.
Hereditary Nonspherocytic Hemolytic Anemia: Type II Pyruvate Kinase Deficient Prototype
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
New Names
Journal: JAMA (1974)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Highlights from this issue
Journal: Thorax (2019)

The TriumvirateFireworks Night is an annual British event that marks the occasion of the foiling of the Gunpowder Plot on the 5 th November 1605.These nocturnal festivities recount the arrest of Guy Fawkes, whilst he was guarding the explosives secretly placed beneath the House of Lords.Airwaves reports the gunpowder, treason and plot found in this month's Thorax… ExpEcting thE unExpEctEd…Guys Fawkes would never have expected to be arrested for his part in the Gunpowder Plot.Indeed, predicting this unplanned event would have been far from the plotter's thoughts.However, Nazir Lone and colleagues (see page 1046).have done exactly that and focused on predicting unplanned events, in this case predicting the risk of unplanned hospital readmission in survivors of critical illness.By population based analysis, and using the Scottish linking registry data for patients discharged from ICU, the authors observed that not only were unplanned 90 day hospital readmissions common following ICU survival, but pre-existing illness better predicted readmission than acute illness.Understanding modifiable risk factors could improve outcome, although this is all a little late for Guys Fawkes and his colleagues who did not plan for the unexpected.
POVERTY AND DISEASE
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Apoptosis in the liver after discontinuation of hepatocyte growth factor administration in rats 1)1st Dept. of Internal Med., Univ. of Tokyo, Tokyo, 2)3rd Dept. of Internal Med., Saitama Medical School, Saitama, 3)Life Science Research Institute, Snow Brand Milk Products Co., Ltd., tochigi, Japan
Journal: Hepatology (1995)

To clarify the role of basophils in the pathogenesis of allergic disease, we developed a new method for performing surface phenotyping of these cells in centrifugation-enriched mononuclear cell fraction. This method identified basophils on the basic of a negative reactivity with mixed FITC-conjugated monoclonal anti-bodies (mAbs) (anti-CD2, -CD14, -CD16, and -CD19) with analysis performed by flow cytometry. The validity of this approach was confirmed by sorting experiments. Various PE-conjugated mAbs were also used to examine binding to FITC-negative basophils. Basophils from asthmatic patients (n = 14) as well as from normal subjects (n = 6) were shown to express CDw32 (FcγRII), CD25 (IL-2R), but not CD64 (FcγRI). We also detected binding of IgG1 and IgG4 to basophils. This method of phenotyping was very rapid and simple. It thus appears to be useful in the study of allergic disease, as well as of the biology of the basophil.
As Number of Trials Increases, Gene Therapy Begins to Look Promising for Medicine's Future
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Development and use of home-care services. Suggestions for physicians
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal