tbuckley/cabot-search huggingface dataset:
Doctor's orders
Authors: R. M. Veatch
Journal: JAMA (1985)

The "do not resuscitate" (DNR) order has become an important phenomenon in the evolution of more responsive and humane care of critically and terminally ill patients. Guidelines for decisions pertaining to resuscitation have been developed and are the source of much research,<sup>1,2</sup>therapeutic discussion,<sup>3,4</sup>and policy debate.<sup>5</sup> Underlying these discussions about decisions to forego resuscitation and a whole range of other decisions in the medical sphere is a broader conceptual problem: the problem of the metaphor of<i>orders</i>. What is going on when an institution as important as health care chooses the image of order giver? At the same time, society and the health professions alike are moving toward a consensual or covenantal model in which the patient makes choices with the support of significant others including family, friends, clergy, and health care professionals. Is the language of order giver compatible with these new, exciting developments that signal
Tobacco Addiction
Authors: Tracy Hampton
Journal: JAMA (2007)

A new genetic study funded by the National Institute on Drug Abuse (NIDA) and the National Cancer Institute has revealed a number of genetic variants that may influence risk for nicotine dependence (Saccone SF et al. Hum Mol Genet. doi:10.1093/hmg/ddl438 [published online November 29, 2006]).
Cell counts of bursal fluid provide a simple test for septic bursitis
Journal: BMJ (1998)

Quality of care before admission to intensive care is often poor Emergency admissions have risen by 50% since 1984, but this rise in quantity should not be at the expense of quality.McQuillan et al (p 1853) used confidential inquiry methods to investigate the quality of care received by a consecutive cohort of 100 adult emergency patients in two hospitals.Oxygen therapy; management of airway, breathing, or circulation; or monitoring was suboptimal in over 50 patients.At least 39 patients were admitted late in their illness.These factors may be associated with increased morbidity and mortality and avoidable admissions to intensive care.The authors suggest a back to basics approach to managing dysfunction of airway, breathing, and circulation.The structure and process of acute care need reviewing to meet the challenge of the increasingly frenetic workload of the NHS.
Medical Organization.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 4422: Molecular and functional characterization of alpha satellite non-coding RNAs
Authors: Rodrigo E. Cáceres, Marco A. Andonegui, Diego A. Oliva, Rodrigo González, Fernando Luna, Cristian G. Arriaga, Alejandro López, Diddier G. Prada, Clementina Castro, Paulina Molina, Carlos De la Rosa, José L. Reyes, Sabrine Hédouin, Florent Hubé, Claire Francastel, Luis A. Herrera
Journal: Cancer Research (2019)

Abstract Eukaryotic cell cycle progression requires the coordination of multiple molecular events in space and time to bring about proper transition from one phase to the next, and to ensure faithful genomic inheritance to daughter cells. The roles of coding transcription, translation, and RNA/protein degradation in cell cycle regulation are straightforward, since they control the abundance of proteins necessary for its progression. However, the contribution of non-coding transcription to this process is poorly understood. Non-coding transcription is notoriously interesting in mitosis for two reasons: First, transcription is repressed in most of the genome, but it is active in the centromere itself during mitosis; second, centromeric transcription produces non-coding RNA molecules which are integral components of the centromere and kinetochore and have functional roles in chromosome segregation. Here, we characterized the centromeric human alpha satellite non-coding RNAs (cencRNAs). We detected that the centromere produces high-molecular-weight (&amp;gt5 kb) alpha satellite transcripts in sense and antisense orientation in several cancer cell lines and normal human leukocytes. These RNAs have a half-life of ~ 30 min and vary in abundance, but not in size, throughout the cell cycle. By analyzing their abundance under various conditions that promote mitotic arrest, we discovered a new association between proteasome inhibition and cencRNAs overexpression in G2/M HCT116 cells. We also show that their transcriptional inhibition mitigates the mitotic arrest induced by proteasome inhibitors. Furthermore, we demonstrate that exogenous expression of cencRNAs can slightly increase the mitotic index of SW480 cells. Using mass spectrometry-coupled RNA pulldown, we discovered that these RNAs interact with proteins essential for chromosome segregation. Our data show that centromeric transcription is regulated by proteasomes. Proteasomal inhibition promotes abnormal mitotic progression owing to the overexpression of non-coding RNAs at the onset of mitosis and the presumed impairment of their partner proteins functions in mitosis. Citation Format: Rodrigo E. Cáceres, Marco A. Andonegui, Diego A. Oliva, Rodrigo González, Fernando Luna, Cristian G. Arriaga, Alejandro López, Diddier G. Prada, Clementina Castro, Paulina Molina, Carlos De la Rosa, José L. Reyes, Sabrine Hédouin, Florent Hubé, Claire Francastel, Luis A. Herrera. Molecular and functional characterization of alpha satellite non-coding RNAs [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4422.
Current Comment
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PTH-087 Fam5C, a Possible Causal Molecule in Ulcerative Colitis Revealed through a Transcriptomic Analysis of the Bowel Mucosa
Authors: P J Smith, A P Levine, G W Sewell, N R O’Shea, M Rodriguez-Justo, M R Novelli, R Vega, S L Bloom, A M Smith, A W Segal
Journal: Gut (2013)

<h3>Introduction</h3> Abnormalities of the colonic mucosa have been implicated in the pathogenesis of ulcerative colitis (UC). We investigated mRNA profiles of macroscopically non-inflamed mucosal biopsies from the colon in patients with UC, Crohn’s disease (CD) and control subjects without gastrointestinal disease (HC), to identify genes that might be involved in the aetiology of the disease. <h3>Methods</h3> Paired biopsies were taken for histology and mRNA extraction from macroscopically non-inflamed mucosa in the ascending and descending colon, and the rectum, from 24 patients with UC, 14 with CD and 27 HCs undergoing routine colonoscopy. Patients were in complete clinical remission and were either on no treatment or on 5-aminosalicylates ± azathioprine. cRNA was hybridised to Illumina HumanHT-12 v4 Expression Beadchips. Array expression data were log transformed and normalised. Only probes with a detection p-value &lt; 0.01 were analysed. Differential gene expression analysis between groups (using p &lt; 0.05 FDR correction) and outlier analysis (p &lt; 0.005, fold change (FC) ≥1.5) were performed at each location using customised software. Results were verified by qPCR and candidate molecules were examined in an independent cohort of UC patients. <h3>Results</h3> In group comparisons, of the 26,261 expressed probes, Family with Sequence Similarity 5, member C (<i>FAM5C</i>) was the only gene to be significantly under-expressed in UC, both in the rectum (FC = –1.58, p = 0.0008) and the descending colon (FC = –1.64, p = 0.0011). Outlier analysis showed that <i>FAM5C</i> was also grossly under-expressed in the ascending colon in 37.5% of UC patients, demonstrating that its expression is abnormal throughout the colon in a significant proportion of individuals. Expression levels were not abnormal in CD. Expression of <i>FAM5C</i> in UC did not correlate with the known markers of inflammation, <i>IL-8</i>, <i>S100A8</i>, <i>DEFA5</i> and <i>DEFA6</i>, or with treatment. The under-expression of <i>FAM5C</i> in UC was confirmed in biopsies of non-inflamed rectal mucosa from an independent cohort of patients (FC = –1.68, p = 0.0073) and by qPCR (p &lt; 0.001). <h3>Conclusion</h3> This is the first description of the under-expression of <i>FAM5C</i> in UC. As these observations were made in non-inflamed mucosa, low levels of this protein might be involved in the pathogenesis of the disease. Indications that <i>FAM5C</i> may function as tumour suppressor [1], could link to the observed predisposition to colonic malignancy in UC. <h3>Disclosure of Interest</h3> None Declared. <h3>Reference</h3> Kuriowa T<i> et al.</i> (2009) Oncol Rep, 1005–11.
Levamisole and interferon in children with chronic hepatitis B
Authors: M Ruiz-Moreno
Journal: Hepatology (1993)

To evaluate the possible usefulness of simultaneous administration of levamisole and interferon, we randomly allocated 38 children with chronic hepatitis B to receive either 10 MU/m2 interferon-α-2a, three times a week for 6 mo (group 1, n = 20) or 90 mg/m2 of levamisole for 45 days, together with 10 MU/m2 of interferon-α-2a, three times a week for 6 mo (group 2, n = 18). At the end of the follow-up period (15 mo), no significant differences were observed between the groups with respect to loss of hepatitis B virus DNA and HBeAg from serum and normalization of serum ALT levels. During therapy, a significant increase in the serum levels of ALT and soluble interleukin-2 receptor was observed in both groups but was higher in patients from group 2. The combination of levamisole with interferon was associated with severe side effects. In summary, the combination of levamisole with interferon in children with chronic hepatitis B does not improve the results obtained with interferon alone. (HEPATOLOGY 1993;18:264–269).
Citations
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cervical osteomyelitis
Authors: J. A. D'Elia
Journal: JAMA (1979)

<h3>To the Editor.—</h3> Drs Parker and Tuazon have succinctly described two patients with vertebral osteomyelitis acquired in association with chronic hemodialysis (240:50, 1978). Other reports have suggested urinary tract disease,<sup>1</sup>intravenous drug abuse,<sup>2</sup>and indwelling intravenous catheters<sup>3</sup>as the route of entry. In a review of our experience with vertebral osteomyelitis among insulin-dependent diabetics,<sup>4</sup>we uncovered only one with chronic bacteriuria and one with prior osteomyelitis as potential portals of entry. Subsequently, we have observed vertebral osteomyelitis in an immunosuppressed patient following successful renal transplantation at a time when glucocorticoid-induced diabetes had developed. We have not found vertebral osteomyelitis in our dialysis patients. Thus, we would emphasize the importance of underlying systemic disease in predisposition to vertebral osteomyelitis, as well as the probability of an increased incidence with the use of immunosuppressive drugs. The absence of an obvious portal of entry reinforces the concept of a diagnostic
Endogenous Bak inhibitors Mcl-1 and Bcl-x<sub>L</sub>: differential impact on TRAIL resistance in Bax-deficient carcinoma
Authors: Bernhard Gillissen, Jana Wendt, Antje Richter, Anja Richter, Annika Müer, Tim Overkamp, Nina Gebhardt, Robert Preissner, Claus Belka, Bernd Dörken, Peter T. Daniel
Journal: The Journal of Experimental Medicine (2010)
American Journal of Diseases of Children, Chicago
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CAT SCRATCH DISEASE AND PARINAUD'S OCULOGLANDULAR SYNDROME
Journal: JAMA (1953)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The AIDS Litigation Project. A national review of court and human rights commission decisions, Part I: The social impact of AIDS
Authors: L O Gostin
Journal: JAMA (1990)

NO OTHER infectious disease in recent history compares with human immunodeficiency virus (HIV) infection in the ways it has affected our relationships with each other and with our social institutions. Sharp differences in perception of public health, ethics, and civil liberties have created the largest body of legal cases attributable to a single disease in the history of American jurisprudence. Litigation related to the acquired immunodeficiency syndrome (AIDS) impacts powerfully on the major social institutions of our nation—schools, health care, the blood supply, the judiciary, prisons, and the military. The litigation has an equal impact on cherished constitutional principles of privacy, freedom of speech and association, and liberty. The HIV epidemic even reaches into intimate personal relationships, sparking litigation against sexual partners and family members. This article is the first in a two-part series reviewing 469 cases that are decided, settled, pending, or filed at the federal, state, and local
Tuberculosis and the Inflammatory Processes of Obesity in Human Evolution—Reply
Authors: Jesse Roth
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BLUE GLASS REDIVIVUS.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Continuous intravenous deferoxamine infusion. Treatment of secondary hemochromatosis in adults
Authors: K. G. Blume
Journal: JAMA (1978)

Adult patients with chronic iron overload were given oral ascorbic acid and continuous intravenous infusions of deferoxamine mesylate. The dosage of deferoxamine mesylate was altered every 48 hours from 1 g/sq m/24 hr to 2 or 4 g/sq m/24 hr. The average iron mobilization was 55.6 mg per day at the 1 g/sq m/24 hr dosage level, 78.6 mg every 24 hours at the 2 g/sq m/24 hr dosage level, and 90.1 mg every 24 hours at the 4 g/sq m/24 hr dosage level. Iron mobilization was undiminished when successive 14-day courses of deferoxamine separated by six-week intervals were administered. (<i>JAMA</i>239:2149-2151, 1978)
1,25-Dihydroxyvitamin D3 is a negative endocrine regulator of the renin-angiotensin system
Authors: Yan Chun Li, Juan Kong, Minjie Wei, Zhou-Feng Chen, Shu Q. Liu, Li-Ping Cao
Journal: Journal of Clinical Investigation (2002)

Inappropriate activation of the renin-angiotensin system, which plays a central role in the regulation of blood pressure, electrolyte, and volume homeostasis, may represent a major risk factor for hypertension, heart attack, and stroke. Mounting evidence from clinical studies has demonstrated an inverse relationship between circulating vitamin D levels and the blood pressure and/or plasma renin activity, but the mechanism is not understood. We show here that renin expression and plasma angiotensin II production were increased severalfold in vitamin D receptor–null (VDR-null) mice, leading to hypertension, cardiac hypertrophy, and increased water intake. However, the salt- and volume-sensing mechanisms that control renin synthesis are still intact in the mutant mice. In wild-type mice, inhibition of 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] synthesis also led to an increase in renin expression, whereas 1,25(OH)2D3 injection led to renin suppression. We found that vitamin D regulation of renin expression was independent of calcium metabolism and that 1,25(OH)2D3 markedly suppressed renin transcription by a VDR-mediated mechanism in cell cultures. Hence, 1,25(OH)2D3 is a novel negative endocrine regulator of the renin-angiotensin system. Its apparent critical role in electrolytes, volume, and blood pressure homeostasis suggests that vitamin D analogues could help prevent or ameliorate hypertension.