tbuckley/cabot-search huggingface dataset:
NHGRI Reorganized
Authors: Bridget M. Kuehn
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hydatid Disease, Vol. II.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical applications of fish oils
Authors: J. Z. Yetiv
Journal: JAMA (1988)

Fish oil supplements are currently being nationally advertised, and many physicians are being queried about their clinical utility. Epidemiologic studies reveal a low incidence of cardiovascular disease in people, such as the Eskimos, who eat large amounts of seafood. Cardiovascular health may be improved because fish and fish oil supplements lower plasma lipid levels (especially triglycerides), inhibit platelet aggregation, and may decrease blood pressure and viscosity and increase high-density lipoprotein (HDL) levels. Preliminary observations also suggest a<i>potential</i>future role for fish oils in the treatment of some autoimmune diseases, such as atopic dermatitis, psoriasis, and rheumatoid arthritis. Patients with serum triglyceride levels greater than 5.64 mmol/L and/or cholesterol levels greater than 7.75 mmol/L refractory to dietary management may benefit from a medically supervised trial of fish oil supplements. Data currently available are insufficient to recommend fish oil supplements for the general public, or for patients with other diseases, and side effects must also be considered. These include occasional<i>adverse</i>lipid changes, potential for bleeding and vitamin E deficiency, and, with some preparations, vitamin A and D toxicity. (<i>JAMA</i>1988;260:665-670)
Acute Kidney Injury
Authors: Andrew S. Levey, Matthew T. James
Journal: Annals of Internal Medicine (2018)

Letters5 June 2018Acute Kidney InjuryAndrew S. Levey, MD and Matthew T. James, MDAndrew S. Levey, MDTufts Medical Center, Boston, Massachusetts (A.S.L.) and Matthew T. James, MDUniversity of Calgary, Calgary, Alberta (M.T.J.)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/L18-0017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Dr. Finucane questions whether a decline in GFR in the setting of an acute illness actually represents injury to the kidney. We believe that this is a question of semantics. Decreased GFR may be viewed as a physiologic response to decreased kidney perfusion, which may resolve rapidly with restoration of perfusion; however, it does not mean that there has been no kidney injury. The current KDIGO criteria for AKI are based on changes in biomarkers related to GFR (serum creatinine level and urine flow rate) without regard to changes in structure or in other biomarkers, and the KDIGO ... Author, Article, and Disclosure InformationAffiliations: Tufts Medical Center, Boston, Massachusetts (A.S.L.)University of Calgary, Calgary, Alberta (M.T.J.)Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=AITC201711070. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAcute Kidney Injury Andrew S. Levey and Matthew T. James Acute Kidney Injury Tom Finucane Acute Kidney Injury Joana Gameiro , Sofia Jorge , and José António Lopes Metrics Cited byAcute kidney injury in Japanese type 2 diabetes patients receiving sodium–glucose cotransporter 2 inhibitors: A nationwide cohort studyA Comprehensive Review of Receptor-Type Tyrosine-Protein Phosphatase Gamma (PTPRG) Role in Health and Non-Neoplastic DiseaseRelationship between early serum sodium and potassium levels and AKI severity and prognosis in oliguric AKI patientsActivation of aryl hydrocarbon receptor by 6‐formylindolo[3,2‐b]carbazole alleviated acute kidney injury by repressing inflammation and apoptosisLinarin Protects the Kidney against Ischemia/Reperfusion Injury via the Inhibition of Bioactive ETS2/IL-12Acute Kidney InjuryPrimary prevention for acute kidney injury in ambulatory patientsAcute Kidney Injury Pharmacokinetic Changes and Its Impact on Drug PrescriptionAcute Kidney Injury in the AgedExpression changes of autophagy-related proteins in AKI patients treated with CRRT and their effects on prognosis of adult and elderly patientsToward Better Stewardship: Gaining Control Over Controlled SubstancesLynn E. Fiellin, MD and David A. Fiellin, MD 5 June 2018Volume 168, Issue 11Page: 837KeywordsAcute kidney injuryAcute renal failureCreatinineDisclosureDrugsNephritisRenal failureSepsisUltrasound imagingUrine ePublished: 5 June 2018 Issue Published: 5 June 2018 Copyright & PermissionsCopyright © 2018 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Asbestos exposure and laryngeal carcinoma
Authors: S. Freifeld
Journal: JAMA (1977)

THE association of asbestos exposure with and an increased incidence of malignant neoplasms has been reported.<sup>1</sup>Two articles have recently suggested an association between exposure to asbestos and an increased incidence of laryngeal carcinoma.<sup>2,3</sup>The three patients of Libshitz et al<sup>2</sup>all had a history of smoking and were treated with radiotherapy or total laryngectomy with apparently good initial results. This is a report of a nonsmoker who worked for 30 years in an asbestos processing plant and who had epidermoid carcinoma involving the left vocal cord. <h3>Report of a Case</h3> A 63-year-old man complained of persistent hoarseness for several months. A biopsy specimen at another hospital prior to referral showed epidermoid carcinoma of the left vocal cord. He had worked for 30 years in a factory concerned with production of asbestos products. A brother had succumbed to pulmonary asbestosis with respiratory insufficiency. A preoperative chest x-ray
Hooked on Hormones?
Authors: Kenneth B. Kashkin
Journal: JAMA (1989)

Widespread illicit anabolic steroid use has recently been reported. A review of available evidence suggests that elevations of serum levels of steroid hormones, including anabolic steroids, have profound psychological effects. Long-term, high-dose anabolic steroid use may lead to a preoccupation with drug use, difficulty stopping despite psychological side effects, and drug craving. Reductions in serum levels of steroid hormones appear to result in acute hyperadrenergic withdrawal symptoms that respond to steroid replacement or to agents that also ameliorate withdrawal symptoms in alcohol and opioid dependence. A delayed depression syndrome when serum steroid levels drop precipitously has been reported that appears similar to that observed in withdrawing cocainedependent individuals. We conclude that a proportion of anabolic steroid abusers may develop a previously unrecognized sex steroid hormone—dependence disorder and that treatment should be based on research into steroid effects on opioid and aminergic neurotransmission systems and relapse prevention. (<i>JAMA</i>. 1989;262:3166-3170)
Constant intravenous insulin infusion in diabetic ketoacidosis
Authors: S. M. Genuth
Journal: JAMA (1973)

Insulin administration by continuous intravenous infusion was evaluated in the therapy of diabetic ketoacidosis. A priming intravenous injection of 50 units followed by continuous infusion of 50 units/hr was employed as a standard protocol. Irrespective of severity, all patients showed clear-cut biochemical and clinical response. Plasma β-hydroxybutyrate levels fell from 11.3 millimols/liter to 1.1 millimols/liter during four to ten hours. Plasma glucose level declined to approximately 300 mg/100 ml or less in an average of five hours. No deaths occurred and there were no complications specifically attributable to this mode of therapy. There are advantages to a standard protocol delivering all insulin by continuous infusion.
Manuscripts Approved for JNCI, April 15 to May 15, 1961
Journal: JNCI Journal of the National Cancer Institute (1961)

Journal Article Manuscripts Approved for JNCI, April 15 to May 15, 1961 Get access JNCI: Journal of the National Cancer Institute, Volume 26, Issue 6, June 1961, Page 1478, https://doi.org/10.1093/jnci/26.6.1478 Published: 01 June 1961
Drug Combo Beats Vemurafenib Alone for Colorectal Cancer
Journal: Cancer Discovery (2017)

Vemurafenib doesn't shrink BRAF-mutated colorectal tumors, but a regimen that also includes irinotecan and cetuximab improves vemurafenib's effectiveness, more than doubling progression-free survival in patients with metastatic tumors. The drug trio also increases disease-control rates.
50-Hertz Magnetic Field and Calcium Transients in Jurkat Cells: Results of a Research and Public Information Dissemination (RAPID) Program Study
Authors: Howard E. Wey, David P. Conover, Patty Mathias, Mark Toraason, W. Greg Lotz
Journal: Environmental Health Perspectives (2000)

An effect on intracellular calcium continues to be proposed as a biochemical pathway for the mediation of biologic effects of electrical-power-frequency magnetic fields (MF). However, reproducible results among laboratories are difficult to attain and the characteristics of magnetic field effects on intracellular free calcium ([Ca(2+)](i)) are not well understood. We attempted to repeat the studies of Lindström et al. [Intracellular Calcium Oscillations in a T-Cell Line by a Weak 50 Hz Magnetic Field. J Cell Physiol 156:395-398 (1993)] by investigating the effect of a 1.5-G 50-Hz MF on [Ca(2+)](i) in the Jurkat lymphocyte T-cell line. Changes in [Ca(2+)](i) were determined using microscopic imaging of fura-2 loaded Jurkat cells on poly-l-lysine-coated glass coverslips. The MF was generated by a single coil constructed with bifilar wire and located in the same plane as the cells. Cells were randomly exposed for 8 min to MF, sham field (SF), or no field (NF) conditions. The exposure condition remained coded until data analysis was complete. Each exposure period was preceded by an 8-min data collection to establish a baseline for [Ca(2+)](i). After each exposure condition, cells were exposed to anti-CD3 antibody that induced a rapid increase in [Ca(2+)](i) in responsive cells; this provided a positive control. [Ca(2+)](i) was analyzed for individual cells as spatially-averaged background-corrected 340/380 nm ratios, and a [Ca(2+)](i) transient was considered significant for positive deviations from baseline of 3 [multiple] an estimate of noise in the baseline. Typically, 25-50 cells/field were viewed and approximately 50% had no [Ca(2+)](i) transients in the baseline period and also responded to positive control. Only cells responding to positive control and lacking changes in [Ca(2+)](i) during the baseline period were considered qualified for assessment during the exposure period. The incidences of [Ca(2+)](i) transients during the exposure period for two experiments (40 [multiple] objective) were 16.5, 14.6, and 14.2% for MF, SF, and NF, respectively, and were not statistically significantly different. Previous studies by Lindström et al. [Intracellular Calcium Oscillations in a T-Cell Line after Exposure to Extremely-Low-Frequency Magnetic Fields with Variable Frequencies and Flux Densities. Bioelectromagnetics 16:41-47 (1995)] showed a high response rate (92%) for exposure to 1. 5-G 50-Hz MF when individual cells were preselected for investigation. We found no such effect when examining many cells simultaneously in a random and blind fashion. These results do not preclude an effect of MF on [Ca(2+)](i), but suggest that responsive cells, if they exist, were not identified using the approaches that we used in this study.
Laboratory Findings in Massively Bleeding Gastroduodenal Ulcers
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Highlights from this issue
Authors: Nicholas Hart, Gisli Jenkins, Alan Smyth
Journal: Thorax (2016)

May is the month of the American Thoracic Society meeting.Once again, we return to California for one of the highlights of the annual calendar.To celebrate the rising submissions, and acceptances, from North American authors and the continued collaboration between the British and American Thoracic Societies, we felt it was an important step to deliver a North American themed issue for May.
Tuberculosis Vaccine
Authors: Tracy Hampton
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Acribia
Authors: Henry J. L. Marriott
Journal: New England Journal of Medicine (1949)

THE practice of medicine is said to be an art as well as a science. Certainly at its best it is a happy blend of both. But today science is nurtured at art's expense, with the unhappy result that doctors are more and more enthralled by numbers and devices, and less and less concerned to cherish precision of their own. Yet this personal precision is as much to be desired as it is sorely lacking, both in clinical skill and in literary expression. The Greeks, as usual, had a word for it, άκῥιβεια, whose shades of meaning have been well . . .
Ranibizumab for Macular Edema Due to Retinal Vein Occlusions; Implication of VEGF as a Critical Stimulator
Authors: Peter A Campochiaro, Gulnar Hafiz, Syed Mahmood Shah, Quan Dong Nguyen, Howard Ying, Diana V Do, Edward Quinlan, Ingrid Zimmer-Galler, Julia A Haller, Sharon D Solomon, Jennifer U Sung, Yasmin Hadi, Kashif A Janjua, Nida Jawed, David F Choy, Joseph R Arron
Journal: Molecular Therapy (2008)
Evaluation continues of 'HBO' clinical uses
Journal: JAMA (1981)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ефективність комбінованого гепатопротектора Форслів у лікуванні хронічних дифузних захворювань печінки
Authors: Yu.M. Stepanov, Yu.S. Breslavets, I.Yu. Zavyalova, S.V. Kosynska, V.B. Yagmur, N.G. Zaichenko, V.M. Gladun, D.V. Popok, M.L. Pleschenko, S.L. Melanych, O.V. Mosyntseva, I.I. Slakva, L.V. Borodina, V.Yu Poleshko, J.V. Stepanova
Journal: GASTROENTEROLOGY (2014)

У статті наведені результати дослідження сироваткового рівня аланінамінотрансферази у хворих на хронічні дифузні захворювання печінки на фоні застосування комплексного гепатопротектора Форслів. За результатами дослідження встановлено вірогідне зниження даного показника у всіх обстежених, що засвідчує ефективність вищезазначеного гепатопротектора.
Reducing Drowsy Driving Crashes
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Investigating the role of TAM family receptors in Merlin deficient tumours
Authors: Dr Sylwia Ammoun, Ms Foram Dave, Dr David Hilton, Dr Claire Ada, Dr Emanuela Elcorano, Dr Sassan Hafizi, Prof Clemens Oliver Hanemann
Journal: Neuro-Oncology (2018)

TAM (TYRO3, Axl and MER) family of receptor tyrosine kinase has been recognised to be upregulated in tumours of diverse origin. Moreover, they are shown to be under negative control of protein merlin, encoded by Neurofibromatosis type II (NF2) gene. Mutation of NF2 gene is responsible for the development of multiple nervous system tumours such as schwannomas, meningiomas and ependymomas. Conventional chemotherapy is ineffective for this group of tumours due to their benign nature, and surgery/radiosurgery carry significant risk due to the multiplicity and location of tumours, thus effective drug therapy is urgently needed. In this study, we are using schwannomas and meningiomas tumour lysates and primary cells to examine the functional and direct correlation of TAM family receptors using confocal microscopy, co-immunoprecipitation and lentivirus based knockdown experiments followed by western blot. Confocal microscopy revealed close association of all three receptors however, co-immunoprecipitation experiments showed direct interaction only between AXL and TYRO3 in schwannomas. Moreover, expression of AXL found to be dependent on TYRO3 and MER. Besides interaction with own members, TAM family receptors also interact with other receptor groups such as integrin β1. Moreover, meningiomas also showed overexpression of all three TAM members in grade-I tumours. Overexpression and activation of TYRO3, AXL and MER found in NF2-/- meningiomas primary cells and which could be reversed on Merlin reintroduction. Investigating the role of TAM family receptors in pathobiology of schwannoma and meningioma will help to determine the best molecule to target therapeutically for NF2 tumours.
Routine preoperative screening for HIV
Journal: JAMA (1988)

<h3>To the Editor.—</h3> I wish to take issue with the SPECIAL COMMUNICATION entitled "Routine Preoperative Screening for HIV: Does the Risk to the Surgeon Outweigh the Risk to the Patient?"<sup>1</sup>The authors, three nonsurgeons, make a number of assumptions, such as a "first-order approximation" of the rate of skin penetration from intraoperative injuries to the surgeon's hands of 2%. The reverse calculation of skin-puncture rate from seroconversion to hepatitis B virus among surgeons is farfetched and not particularly pertinent. More pertinent would be an attempt to estimate the highest possible risk. Such data are critical to those of us who are exposed. The skin-puncture rate could be assumed to be equal to the glove-puncture rate, since multiple punctures may occur during the same procedure and frequent glove changes are common. If the glove-puncture rate is 25% and the risk of human immunodeficiency virus (HIV) infection after skin puncture is