tbuckley/cabot-search huggingface dataset:
Anti-idiotype antibodies may do what vaccines don't
Authors: K. Simmons
Journal: JAMA (1986)

A new type of vaccine that may prove useful for protecting humans against a variety of diseases is being developed in experimental animals and reportedly has produced immunity against numerous viruses, bacteria, and parasites. Reports say that, with this vaccine (and unlike conventional vaccines), no pathogenic antigen is needed to stimulate the host's immunity. Instead, this approach enlists "anti-idiotype antibodies." An idiotype—the site where an antigen binds to an antibody—can itself act as an antigen to stimulate antibody production. Antibodies that are stimulated by idiotypes are called anti-idiotype antibodies. If the idiotype could be represented by a domino with, say, four dots, the antigen might be a four-two combination and the anti-idiotype antibody might be a four-three. Both will hook up with the idiotype even though they are different "molecules." It is debatable how far in the future this technique will be tried in humans. Some researchers suggest it will
A medical non sequitur
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Oral Contraceptive Steroids as Promoters or Complete Carcinogens for Liver in Female Sprague-Dawley Rats
Authors: James D. Yager
Journal: Environmental Health Perspectives (1983)

Published reports have described an increased incidence of adenomas and of hepatocellular carcinomas in livers of women with a history of long-term oral contraceptive use. Evidence derived from human and experimental animals suggests that oral contraceptive steroids may be liver tumor promoters. Experiments were designed to determine the initiating and/or promoting potential of two oral contraceptive steroids, namely mestranol and norethynodrel. The results show that: mestranol and norethynodrel can promote DEN-initiated hepatocarcinogenesis, as indicated by increased numbers of gamma-glutamyl transpeptidase-positive, putative preneoplastic lesions and by the appearance of carcinomas. Various synthetic estrogens fail to cause detectable levels of DNA damage in hepatocytes. Mestranol has weak, if any, initiating potential. Neither mestranol nor norethynodrel exhibits antiglucocorticoid activity. Mestranol and norethynodrel inhibit metabolic cooperation in V-79 Chinese hamster cells. Taken together, these results and those reported by others demonstrate that oral contraceptive steroids are relatively strong promoters of hepatocarcinogenesis and have little if any genotoxic effect.
Effects of ventilation, humidity and temperature on airway responsiveness to methacholine in rats
Authors: F.M. Arantes-Costa, S. Zoriki, M.H.C. Santos, C.H.P. Kobata, J.E. Vieira, M.A. Martins
Journal: European Respiratory Journal (1999)

The six minute walking distance (6MWD) test is a commonly used test to estimate functional exercise capacity in patients with chronic diseases including chronic obstructive lung disease. Surprisingly, no attempt has been made to establish normal values for the 6MWD. The aim of this study, therefore, was to evaluate the 6MWD in healthy elderly volunteers and to evaluate its determining factors. Fifty-one healthy subjects aged 50-85 yrs volunteered to participate in the trial. All subjects were free of diseases that could interfere with performance in a walking test. Tests were performed in a quiet 50-m long hospital corridor. Patients were encouraged every 30 s to continue walking as quickly as possible. Walking distance averaged 631+/-93 m and was 84 m greater in the male compared to female subjects (p&lt;0.001). The 6MWD showed significant correlations with age (r=-0.51, p&lt;0.01) and height (r=0.54, p&lt;0.01). Stepwise multiple regression analysis showed that age, height, sex and weight were independent contributors to the 6MWD in healthy subjects, thus explaining 66% of the variability. It is concluded that the six minute walking distance can be predicted adequately using a clinically useful model in healthy elderly subjects. Its variability is explained largely by age, sex, height and weight. Results of the six minute walking distance may be interpreted more adequately if expressed as a percentage of the predicted value.
Blue vitiligo
Authors: R Ivker, M Goldaber, M R Buchness
Journal: Journal of the American Academy of Dermatology (1994)

The progression of vitiligo and postinflammatory hyperpigmentation simultaneously in a patient with AIDS led to the appearance of a blue color on much of the patient's skin. The blue coloration subsequently resolved with follicular repigmentation typical of resolving vitiligo. We believe this is the first reported case of "blue vitiligo."
The Scientific Exhibit
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TETANUS BACILLI IN THE HUMAN INTESTINE.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The use (and misuse) of urinary sodium and chloride measurements
Authors: R. A. Sherman
Journal: JAMA (1982)

MEASUREMENT of urinary sodium and chloride concentrations is useful whenever knowledge of whether the kidney is retaining salt will narrow the differential diagnosis. Any concentration of sodium or chloride in the urine is normal if it favors maintenance of normal systemic fluid and electrolyte status. Only when a patient's fluid and electrolyte status is abnormal and one can predict what a normal kidney's protective response would be can study of the urine electrolytes be of value. <h3>Detection of a Salt-Retaining State</h3> Urinary sodium and urinary chloride concentrations should both be determined whenever the concentration of one or the other electrolyte is sought. If the kidney is in a saltretaining state, both urinary sodium and chloride concentrations usually are less than 20 mEq/L. It is, however, not unusual for one or the other electrolyte level to be deceptively high due to the need for electroneutrality in the urine. For example, in
Knock your SOCS off!
Authors: Derek LeRoith, Peter Nissley
Journal: Journal of Clinical Investigation (2005)

The growth hormone/IGF-1–signaling (GH/IGF-1–signaling) system is involved in numerous physiological processes during normal growth and development and also in the aging process. Understanding the regulation of this system is therefore of importance to the biologist. Studies conducted over the past decade have shown that the JAK/STAT pathways are involved in GH signaling to the nucleus. More recently, evidence has been presented that a member of the SOCS family, SOCS2, is a negative regulator of GH signaling. This story began several years ago with the dramatic demonstration of gigantism in the SOCS2-knockout mouse. A more specific definition of the role of SOCS2 in GH signaling is provided in this issue of the JCI by the demonstration that the overgrowth phenotype of the SOCS2–/– mouse is dependent upon the presence of endogenous GH and that administration of GH to mice lacking both endogenous GH and SOCS2 produced excessive growth.
Smallpox Redux?
Authors: Lola V. Stamm
Journal: JAMA Dermatology (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Response to Letter Regarding Article, “High-Dose Folic Acid Pretreatment Blunts Cardiac Dysfunction During Ischemia Coupled to Maintenance of High-Energy Phosphates and Reduces Postreperfusion Injury”
Authors: An L. Moens, Hunter C. Champion, Azeb Haile, Muz Zviman, Djahida Bedja, Kathy L. Gabrielson, Nazareno Paolocci, David A. Kass, Rebecca S. Elsaesser, Marc J. Claeys, Dirk J. Borgonjon, Paul Cos, Christiaan J. Vrints, Luc Van Nassauw, Jean-Pierre Timmermans, Floris L. Wuyts, Barbara Tavazzi, Giuseppe Lazzarino, Pawel M. Kaminski, Michael S. Wolin
Journal: Circulation (2008)
Enteritis and colitis associated with mefenamic acid
Authors: Andrie Schulman
Journal: BMJ (1984)

Voicing opposition to "apartheid" is, in most sectors of South African society, as prudent and fashionable as it is outside South Africa.It is unfortunate that the South African newspapers referred to by Mr Bennun are unavailable to most BMJ readers.A reading in toto of each of the articles referred to does not in fact give the same impression of maltreatment and malpractice produced by Mr Bennun's extracts.65Also, in the case of the trial of Mr Motaung, although Mr Bennun refers to the Rand Daily Mail of 28 and 29 July 1982, and the Sowetan of 29 July, he does not refer to their 30 July issues.On this date, the Rand Daily Mail reported the judge to have summed up: that the accused had lied about the extent of his injuries and the pain he had suffered; that his bullet wounds were not that serious; that' the security police had not deliberately kept him from seeing a doctor or sending him to hospital; that his demeanour in the witness box was thoroughly unsatisfactory; and that he had fabricated his evidence.9According to the Sowetan, the judge found the accused to have been a shrewd person in the witness box and quoted the district surgeon as saying that one shot had grazed the accused's private parts and that he had also suffered a super- ficial wound.10The events giving rise to the trial consisted of multiple killings, attempted killings, and attacks on police and power stations by a gang armed with AK-47 rifles, TNT explosives, and hand grenades.5Mr Bennun is making a sociolegal study of the application of South African security laws.This is, I imagine, a feasible undertaking because of the wealth of independent news- paper reporting and reliable documentation of open court hearings, a set of circumstances now unique in Africa.Without being entirely rhetorical, may I ask Mr Bennun how he would do a similar study of African Common- wealth countries ?What would be the sources of one's research material ?
Government Services
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TUBERCULOSIS OF THE THORACIC DUCT.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Symposium on Management of Gaseous Wastes From Nuclear Facilities
Journal: JNCI Journal of the National Cancer Institute (1979)

Journal Article Symposium on Management of Gaseous Wastes From Nuclear Facilities Get access JNCI: Journal of the National Cancer Institute, Volume 63, Issue 1, July 1979, Page 269, https://doi.org/10.1093/jnci/63.1.269-c Published: 01 July 1979
Analyses of intermediate-stage hepatocellular carcinoma patients receiving transarterial chemoembolization before designing clinical trials comparing transarterial chemoembolization and immune checkpoint inhibitor-based therapies
Authors: Keisuke Koroki, Sadahisa Ogasawara, Yoshihiko Ooka, Hiroaki Kanzaki, Kengo Kanayama, Susumu Maruta, Kazufumi Kobayashi, Soichiro Kiyono, Masato Nakamura, Naoya Kanogawa, Tomoko Saito, Takayuki Kondo, Eiichiro Suzuki, Shingo Nakamoto, Akinobu Tawada, Tetsuhiro Chiba, Makoto Arai, Tatsuo Kanda, Hitoshi Maruyama, Jun Kato, Satoshi Kuboki, Masayuki Ohtsuka, Naoya Kato
Journal: Journal of Hepatology (2020)
The Anatomy of the Human Head and Neck.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cerebral tuberculoma
Authors: P D. G Rajakaruna
Journal: Thorax (2006)

Cerebral tuberculomaA 22 year old HIV negative Asian woman was diagnosed with tuberculosis (TB) following onset of cough, fevers, and weight loss.A chest radiograph showed bilateral reticulonodular shadowing and bronchoscopy cultured fully sensitive Mycobacterium tuberculosis.She began routine quadruple therapy and her symptoms resolved.Four months into treatment she developed an occipital headache, tinnitus and diplopia, with papilloedema on examination.A CT scan (Niopam contrast enhanced, 5 mm slices) showed multiple ring enhancing lesions in the cerebral hemispheres and brainstem consistent with cerebral tuberculomas (fig 1), but no signs of raised intracranial pressure.An MRI scan (non-contrast) revealed an asymptomatic tuberculoma in the lower spinal cord (fig 2).The patient was treated with high dose oral steroids and continuation of her antituberculous chemotherapy, with resolution of all symptoms.Cerebral tuberculomas are a rare but well recognised complication of TB and most cases have associated tuberculous meningitis.Paradoxical development or enlargement of tuberculomas during antituberculous chemotherapy has also been reported, and possibly has an immunological basis. 1-3 Treatment is with high dose steroids and continuation of antituberculous therapy, often for a prolonged course.Surgery has been used in isolated cases. 4 5Tuberculomas should be considered in patients with TB presenting with focal neurology or signs of raised intracranial pressure, even when established on treatment.
The nuclear receptor PPARγ selectively inhibits Th17 differentiation in a T cell–intrinsic fashion and suppresses CNS autoimmunity
Authors: Luisa Klotz, Sven Burgdorf, Indra Dani, Kaoru Saijo, Juliane Flossdorf, Stephanie Hucke, Judith Alferink, Nina Novak, Marc Beyer, Gunter Mayer, Birgit Langhans, Thomas Klockgether, Ari Waisman, Gerard Eberl, Joachim Schultze, Michael Famulok, Waldemar Kolanus, Christopher Glass, Christian Kurts, Percy A. Knolle
Journal: The Journal of Experimental Medicine (2009)