tbuckley/cabot-search huggingface dataset:
PROFESSIO
Authors: HUGH J.  MORGAN
Journal: Annals of Internal Medicine (1948)

Article1 May 1948PROFESSIOHUGH J. MORGAN, M.D., D.SC., F.A.C.P.HUGH J. MORGAN, M.D., D.SC., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-28-5-887 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Excerpt"In nothing do men more nearly approach the gods than in giving health to men."Cicero: Pro Q. Ligario Oratio.The 1948 Class of Fellows and Associates convened here for induction into the American College of Physicians finds itself in troubled times. Three years ago we were quite sure we had seen the end of a global war. With hope, with confidence even, we projected our thoughts into the future. We envisioned the resumption of our accustomed professional activities in a world at peace. We were eager to redeem the personal independence which in the time of national emergency we...Bibliography1. BUSH V: Endless horizons, 1946, The Public Affairs Press, Washington. Google Scholar2. BISHOP EL: Some traditions and responsibilities of the medical profession, Ky. Med. Jr., 1937, xxxv, 526-530. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Vanderbilt University School of Medicine Nashville, Tennessee*Presidential Address, Annual Convocation, American College of Physicians, San Francisco, April 21, 1948. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1948Volume 28, Issue 5Page: 887-891KeywordsForecasting ePublished: 1 December 2008 Issue Published: 1 May 1948 Copyright & PermissionsCopyright, 1948, by The American College of PhysiciansPDF downloadLoading ...
The sexual identity of athletes
Authors: Keith L. Moore
Journal: JAMA (1968)

The question of whether certain female athletes are in fact female will certainly arise during medical examinations at the Olympics, even though the obviously doubtful cases will likely remain at home. The rapid advances registered during the last decade in our understanding of sex and its aberrations have resulted in confusion in the minds of some, however, concerning the contribution of various factors (genetic, gonadal, hormonal) towards the sexual identity of an individual.<sup>1</sup>As a result, females have been declared ineligible for athletic competition for no other apparent reason than the presence of an extra chromosome, presumably in the sex chromosome complex. This seems grossly unfair if other criteria of sex conform with the person's social sex. In most individuals the nine components of sexual phenotype (external genital appearance, internal reproductive organs, structure of the gonads, endocrinologic sex, genetic sex, nuclear sex, chromosomal sex, psychological sex, social sex) conform
Environmental Endocrine Disruption: An Effects Assessment and Analysis
Authors: Thomas M. Crisp, Eric D. Clegg, Ralph L. Cooper, William P. Wood, David G. Anderson, Karl P. Baetcke, Jennifer L. Hoffmann, Melba S. Morrow, Donald J. Rodier, John E. Schaeffer, Leslie W. Touart, Maurice G. Zeeman, Yogendra M. Patel
Journal: Environmental Health Perspectives (1998)

This report is an overview of the current state of the science relative to environmental endocrine disruption in humans, laboratory testing, and wildlife species.Background information is presented on the field of endocrinology, the nature of hormones, and potential sites for endocrine disruption, with specific examples of chemicals affecting these sites.An attempt is made to present objectively the issue of endocrine disruption, consider working hypotheses, offer opposing viewpoints, analyze the available information, and provide a reasonable assessment of the problem.Emphasis is placed on disruption of central nervous system-pituitary integration of hormonal and sexual behavioral activity, female and male reproductive system development and function, and thyroid function.In addition, the potential role of environmental endocrine disruption in the induction of breast, testicular, and prostate cancers, as well as endometriosis, is evaluated.The interrelationship of the endocrine and immune system is documented.With respect to endocrine-related ecological effects, specific case examples from the peer-reviewed literature of marine invertebrates and representatives of the five classes of vertebrates are presented and discussed.The report identifies some data gaps in our understanding of the environmental endocrine disruption issue and recommends a few research needs.Finally, the report states the U.
VITAMIN, APPETITE AND DIGESTION
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Onset Enuresis
Authors: J. D. Paulett, E. Tuckman
Journal: BMJ (1958)

RENAL FUNCTION IN SCLERODERMA BRITLJH why the usual clinical tests fail at an early stage, and may even fail completely, to show. the presence of diseased kidneys.Once this equilibrating mechanism is upset, for whatever reason, renal function will rapidly deteriorate and uraemia develop.The morphological manifestation of this train of events constitutes what has been termed a "true scleroderma kidney."Summary In a small percentage of cases scleroderma produces characteristic morphological changes in the kidney.These consist of mucoid proliferation, accompanied by gross reduction in lumen, of the proximal parts of the interlobular arteries, while the distal parts of these arteries exhibit a fibrinoid necrosis extending to the arterioles.In the parenchyma of the renal cortex ischaemic necroses occur.The case is reported of a woman aged 43 who developed acute renal failure shortly after the institution of steroid therapy for polymyositis.The renal histology followed the pattern seen in " true scleroderma kidney."Out of 25 patients suffering'from scleroderma of vary- ing severity 80% showed a reduced CP.A.H. (for the esti- mation of R.P.F.), normal Ccr., and increased F.F. From this it is concluded that the finding of a reduced R.P.F.furnishes an earlier indication of sclerodermal renal involvement than do the commonly used clinical tests.Reduced CP.A.H., normal Ccr., and increased F.F. indi- cate that the anatomical changes in the preglomerular arteries are accompanied by spasm of the efferent vessels.The presence of a compensatory mechanism serving to maintain, so far as possible, maximum glom- erular function in the presence of a diseased renal vascu- lar system is suggested.
A Pictorial Atlas of Skin Diseases and Syphilitic Affections in Photo-lithochromes from Models in the Museum of the Saint Louis Hospital, Paris, with explanatory woodcuts and text by Ernest Besnier, A. Fournier, Tenneson, Hallopeau, Du Castel, Henri Feulard and L. Jacquet.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Scientists in the Courtroom: Basic Pointers for the Expert Scientific Witness
Authors: David L. Eaton, David Kalman
Journal: Environmental Health Perspectives (1994)

The need for expert and unbiased participation in legal proceedings by physicians, industrial hygienists, toxicologists, environmental scientists, regulators, and similar professionals is hampered by lack of familiarity with the requirements of expert testimony and lack of opportunities for professional training in this activity. Drawing on material developed in a continuing education course offered by the University of Washington, we describe the role and process of being an expert witness and provide basic information regarding good professional practices pertaining to the testifying expert role.
Organ‐on‐a‐Chip for Cancer and Immune Organs Modeling
Authors: Wujin Sun, Zhimin Luo, Junmin Lee, Han‐Jun Kim, KangJu Lee, Peyton Tebon, Yudi Feng, Mehmet R. Dokmeci, Shiladitya Sengupta, Ali Khademhosseini
Journal: Advanced Healthcare Materials (2019)

Adv. Healthcare Mater. 2019, 8, 1801363 The following conflict of interest statement was not included in the original publication of this article. The conflict of interest is: S.S. holds equity in Mitra Biotech (Mitra Life Sciences). The authors apologize for any confusion caused.
Renograms
Authors: R. G. Luke, A. C. Kennedy
Journal: BMJ (1963)

<h3>Abstract</h3> Heritability, genetic correlation and genetic associations estimated from samples of unrelated individuals are often perceived as confirmation that genotype causes the phenotype(s). However, these estimates can arise from indirect mechanisms due to population phenomena including population stratification, dynastic effects, and assortative mating. We introduce these, describe how they can bias or inflate genotype-phenotype associations, and demonstrate methods that can be used to assess their presence. Using data on educational achievement and parental socioeconomic position as an exemplar, we demonstrate that both heritability and genetic correlation may be biased estimates of the causal contribution of genotype. These results highlight the limitations of genotype-phenotype estimates obtained from samples of unrelated individuals. Use of these methods in combination with family-based designs may offer researchers greater opportunities to explore the mechanisms driving genotype-phenotype associations and identify the causes of estimate bias.
Recurrence risk perception and quality of life after treatment of breast cancer.
Authors: Sarah T. Hawley, Nancy K. Janz, Kent A. Griffith, Christopher Ryan Friese, Ann S. Hamilton, Steven J. Katz
Journal: Journal of Clinical Oncology (2016)

6516 Background: Little is known about the patterns & correlates of recurrence risk overestimation and impact on quality of life of patients with breast cancer. We explored 2 types of risk perception (numeric and descriptive) in a large, diverse population of breast cancer patients with favorable prognosis and assessed associations between overestimation and quality of life (QoL).Methods: We surveyed a weighted random sample of newly diagnosed patients with early-stage breast cancer treated in 2013-14, identified through population-based SEER registries of Los Angeles & Georgia ~3 months after surgical treatment (N=2632, RR=70%). Actual 10-year risk of distant recurrence after treatment was constructed based on clinical factors for women with DCIS (N=502) & with low risk invasive cancer (LRI: N=520, Stg 1A, ER+HER2-, Gr 1-2). Women reported perceptions of their risk numerically (0 – 100%), with values >9% for DCIS and > 19% for LRI considered overestimates. Women also reported their perceived risk descriptively, with perceptions of “moderate, high or very high” risk considered overestimates. We assessed patient and treatment correlates of both types of overestimation and report the multivariable associations between overestimation and the QoL measures of worry & PROMIS physical and mental health. Results: 38% of DCIS and 27% of women with LRI breast overestimated their risk numerically, and 13% of DCIS and 18% of LRI descriptively. Both risk overestimation measures were significantly (P< 0.01) associated with less education. In multivariable models, both overestimation measures were significantly (P<0.01) associated with more frequent worry about recurrence, and descriptive overestimation with lower PROMIS physical & mental health (P<0.01). In all models, descriptive overestimation was more strongly associated with poor outcomes than numeric overestimation. Conclusions: Marked overestimation of risk after treatment was common. Strong associations between risk overestimation and lower QoL underscores the importance of correcting risk perception. In particular, the strong influence of descriptive assessments of risk suggests the need for clinicians to discuss actual risk in ways that can be clearly understood.
Effects of immunotherapy on symptoms, PEFR, spirometry, and airway responsiveness in patients with allergic asthma to house-dust mites (D. pteronyssinus) on inhaled steroid therapy
Authors: J. C. Torres Costa, J. L. Plácido, J. P. Moreira Silva, L. Delgado, M. Vaz
Journal: Allergy (1996)

The present study was designed to investigate the effects of immunotherapy (IT) with an extract of Dermatophagoides pteronyssinus (Alergo-Merck Depot®) during a 27-month period in patients with allergic asthma to house-dust mites. We included 11 patients (mean age 18 years) treated with a combination of IT and inhaled beclomethasone dipropionate (BDP) in comparison to another II (mean age 22 years) treated with BDP alone. We evaluated symptom scores, salbutamol use, peak expiratory flow rates (PEFR), spirometry, and bronchial hyperresponsiveness (BHR) during 18 months of therapy with BDP and in the 9 months after BDP interruption. The two kinds of treatment were efficient and comparable in relation to symptom score, salbutamol use, morning PEFR, FVC, and FEV1, but patients treated with IT and BDP had a faster improvement of BHR and PEFR variability. The interruption of BDP after 18 months of therapy was linked to an impairment of all end points, which were more pronounced in patients previously treated only with BDP. These findings suggest that in selected asthmatic patients allergic to house-dust mites, the association of IT and BDP is more effective than therapy with this inhaled steroid alone due to a faster and more striking improvement during the first months of treatment and to a lower rate of relapse after the interruption of therapy with BDP.
Bacterial induction of autoantibodies to β2-glycoprotein-I accounts for the infectious etiology of antiphospholipid syndrome
Authors: Miri Blank, Ilan Krause, Mati Fridkin, Nathan Keller, Juri Kopolovic, Iris Goldberg, Ana Tobar, Yehuda Shoenfeld
Journal: Journal of Clinical Investigation (2002)

The antiphospholipid syndrome (APS) is characterized by the presence of pathogenic autoantibodies against β2-glycoprotein-I (β2GPI). The factors causing production of anti-β2GPI remain unidentified, but an association with infectious agents has been reported. Recently, we identified a hexapeptide (TLRVYK) that is recognized specifically by a pathogenic anti-β2GPI mAb. In the present study we evaluated the APS-related pathogenic potential of microbial pathogens carrying sequences related to this hexapeptide. Mice immunized with a panel of microbial preparations were studied for the development of anti-β2GPI autoantibodies. IgG specific to the TLRVYK peptide were affinity purified from the immunized mice and passively infused intravenously into naive mice at day 0 of pregnancy. APS parameters were evaluated in the infused mice on day 15 of pregnancy. Following immunization, high titers of antipeptide [TLRVYK] anti-β2GPI Ab's were observed in mice immunized with Haemophilus influenzae, Neisseria gonorrhoeae, or tetanus toxoid. The specificity of binding to the corresponding target molecules was confirmed by competition and immunoblot assays. Naive mice infused with the affinity-purified antipeptide Ab's had significant thrombocytopenia, prolonged activated partial thromboplastin time and elevated percentage of fetal loss, similar to a control group of mice immunized with a pathogenic anti-β2GPI mAb. Our study establishes a mechanism of molecular mimicry in experimental APS, demonstrating that bacterial peptides homologous with β2GPI induce pathogenic anti-β2GPI Ab's along with APS manifestations.
Evaluation of a new antipsychotic agent: thiothixene (Navane)
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Catarrhal Child
Authors: A. I. Goodman
Journal: BMJ (1956)

A 5-year-old, 29-kg, female Labrador retriever developed tachypnea, tachycardia, and ataxia following ingestion of approximately 48 mg/kg of phenylpropanolamine. Initial diagnostic tests showed multiform ventricular tachycardia, left ventricular dilatation with a focal dyskinetic region in the dorsal interventricular septum, and elevations in creatinine kinase and cardiac troponin I. All abnormalities resolved within 6 months. The transient electrocardiographic, echocardiographic, and biochemical abnormalities were consistent with myocardial necrosis from infarction or direct catecholamine-induced myocardial toxicity.
Association of unstable hemoglobin variants and heterozygous β‐thalassemia: Example of a new variant Hb acharnes or [β53(D4) Ala → Thr]
Authors: I. Papassotiriou, J. Traeger‐Synodinos, D. Promé, J. Kister, E. Stamou, T. Liakopoulou, A. Stamoulakatou, E. Kanavakis, H. Wajcman
Journal: American Journal of Hematology (1999)

We report here the functional and structural characterization of Hb Acharnes [β53(D4) Ala → Thr], an unstable and electrophoretically silent variant, that was found associated in trans with a β0-thalassemic mutation (IVSI-1 G → A), in a patient with thalassemia intermedia syndrome. This case is discussed in comparison with other sporadic cases that we have previously investigated, resulting from the co-inheritance of a β0-thalassemic mutation (CD39 C → T) with two other types of unstable hemoglobins, Hb Köln [β98(FG5) Val → Met], and Hb Arta [β45(CD4) Phe → Cys]. It may be concluded that, in these associated forms, both the degree of instability of the variant and the altered oxygen binding properties (affecting the degree of tissue hypoxia) are major determinants of their clinical expression. Am. J. Hematol. 62:186–192, 1999. © 1999 Wiley-Liss, Inc.
Translational Highlights from The Endocrine Society Journals
Journal: Endocrine Reviews (2013)

Translocator protein (TSPO; 18 kDA) is a high-affinity cholesterolbinding protein that is integrally involved in cholesterol transfer from intracellular stores into mitochondria, the rate-determining step in steroid formation.Previous studies have shown that TSPO drug ligands are able to activate steroid production by MA-10 mouse Leydig tumor cells and by mitochondria isolated from steroidogenic cells.We hypothesized herein that the direct, pharmacological activation of TSPO might induce aged Leydig cells, which are characterized by reduced T production, to produce significantly higher levels of T both in vitro and in vivo.To test this, we first examined the in vitro effects of the TSPO selective and structurally distinct drug ligands N,N-dihexyl-2-(4-fluorophenyl)indole-3-acetamide (FGIN-1-27) and benzodiazepine 4Јchlorodiazepam (Ro5-4864) on steroidogenesis by Leydig cells isolated from aged (21-24 months old) and young adult (3-6 months old) Brown Norway rats.The ligands stimulated Leydig cell T production significantly, and equivalently, in cells of both ages, an effect that was significantly inhibited by the specific 17,.Additionally, we examined the in vivo effects of administering FGIN-1-27 to young and aged rats.In both cases, serum T levels increased significantly, consistent with the in vitro results.Indeed, serum T levels in aged rats administered FGIN-1-27 were equivalent to T levels in the serum of control young rats.Taken together, these results indicate that although there are reduced amounts of TSPO in aged Leydig cells, its direct activation is able to increase T production.We suggest that this approach might serve as a therapeutic means to increase steroid levels in vivo in cases of primary hypogonadism.
PROTEOGENS IN SYPHILIS
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal