tbuckley/cabot-search huggingface dataset:
Gastroenterology, Baltimore
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical Trials
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Aspiration of a Dental Appliance in a Patient With Alzheimer Disease
Authors: J. S. Oghalai
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pseudoeventration of right diaphragm
Authors: S. F. Reich
Journal: JAMA (1979)

<h3>History</h3> A 70-year-old man gave a history of shortness of breath, which had become worse in the week before admission. He had had cyanosis for three weeks. He had been treated for active pulmonary tuberculosis with chemotherapy in 1969. His blood pressure was 130/100 mm Hg; respirations, 44/min. He had venous distension of the neck but no murmurs or gallop rhythm. There were rales at both bases with diminished breath sounds at the right base. His extremities were cyanotic and cool. The admission posteroanterior and lateral teleroentgenograms are shown in Fig 1 and 2. <h3>Diagnosis</h3> Subpulmonic effusion. <h3>Comment</h3> Figure 1 shows what seems to be a lobulated elevation of the right hemidiaphragm. It extends to the level of the eighth posterior rib. There is slight blunting of the right costophrenic sulcus. Residual tuberculosis is seen in the right upper lobe. The heart is enlarged. Figure 2 shows blunting of the
Missing Title
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Controversies: Does the CD4+ Cell Count Reflect Clinical Efficacy?
Authors: Sabine Kinloch-de-Loës
Journal: JAMA (1996)

<h3>To the Editor.</h3> —We enjoyed reading Dr Levy's<sup>1</sup>Controversies on surrogate markers in acquired immunodeficiency syndrome research and concur with much of his analysis. However, on a few occasions, he may have carried his argument too far. For instance, we agree that the relationship between low viral load and favorable clinical outcomes seen in studies of the natural history of disease does not necessarily imply that similar benefits will be achieved when viral load is reduced by medication. But there is no logical reason to conclude that "a beneficial clinical outcome cannot be expected unless drug therapies mimic the natural cellular immune responses that lower the viral RNA." No clinically effective antiviral drug does this. Nor is this desirable, since natural immune responses have proved incapable of neutralizing the human immunodeficiency virus (HIV) in the long run. The value of a treatment regimen should be judged by its clinical
NIMG-14. MULTIREGIONAL RADIOMICS PROFILING FROM MULTIPARAMETRIC MRI: IDENTIFYING AN IMAGING PREDICTOR OF IDH1 MUTATION STATUS IN GLIOBLASTOMA MULTIFORME
Authors: Yin-sheng Chen, Zhong-ping Chen, Zhicheng Li, Hongmin Bai, Chaofeng Liang
Journal: Neuro-Oncology (2018)

Glioblastoma Multiforme (GBM) patients with isocitrate dehydrogenase 1 (IDH1) mutations have significantly improved prognosis than those without such mutations. We aimed to preoperatively predict IDH1 mutation status in GBM using multiregional radiomics features from multiparametric magnetic resonance imaging (MRI). In total 225 patients were recruited in this retrospective multicenter study. 1614 quantitative features were extracted from multiple tumor subregions (including enhancement area, non-enhancement area, necrosis and edema) in multiparametric MRI. After intensity normalization, tumor subregion segmentation, resampling-based data balancing and relevant feature selection, a multiregional radiomics model was built using a machine-learning method for prediction of IDH1 mutation from a primary cohort (118 patients) and tested on an independent validation cohort (107 patients). Four single-region radiomics models with features from each tumor subregion, and a model combining multiregional features with clinical factors (age, sex, and Karnofsky performance status) were also built and tested. Among four single-region radiomics models, the model built from edema region achieved the best accuracy of 96% and the best F1-score of 0.75 in the independent validation cohort. The 8-feature multiregional radiomics model achieved an improved overall performance of an accuracy 96%, an AUC 0.90 and an F1-score 0.78 in the validation cohort, which significantly outperformed the single-region models. Among all predictive models, the model combining multiregional imaging features with patient age achieved the best performance of an accuracy 97%, an AUC 0.96 and an F1-score 0.84 in the validation cohort. The radiomics-based model built with a minimal set of multiregional features from multiparametric MRI has the potential to preoperatively detect the IDH1 mutation status in GBM patients. The proposed predictor may serve as a potential noninvasive biomarker to guide preoperative GBM patient care. Keywords: Radiomics, IDH1 mutation, Multiregional imaging analysis, Glioblastoma multiforme
Ingrowing toenails
Authors: H R Youngman
Journal: BMJ (1985)

<b>Introduction:</b> Exacerbations of bronchiectasis are associated with increased airways and systemic inflammation therefor in time proper antibiotics during exacerbation are very important. <b>Objective:</b> Find the association of pathogen in bronchiectasis patient between clinically stable and during exacerbation for answering the question whether using the previous clinically stable sputum culture results are able to predict the exacerbation pathogen or not. <b>Study design:</b> Retrospective Cohort study <b>Materials and Methods:</b> Reviewing good quality and significant sputum culture results in clinically stable and during exacerbation in 98 non-cystic fibrosis bronchiectasis patients who were not exposed to inhaled or oral antibiotic for 3 months before collecting the sputum. <b>Results:</b> Most of bronchiectasis patient in this study were diffused lesion (68.6%). Previous tuberculosis infection (50.3%), idiopathic (24%) and rheumatoid arthritis (5.1%) were common causes of bronchiectasis. First three commonly pathogens being found in clinically stable sputum results were non-mycobacterium tuberculosis (30.61%), <i>Pseudomonas aeruginosa</i> (29.59%), <i>Hemophilus influenza</i> (25.51%) and during exacerbation were <i>Pseudomonas aeruginosa</i> (50.98%), <i>Klebsella pneumoniae</i> (28.43%), <i>Hemophilus influenza</i> (4.9%). Agreement for detection of bacteria by culture during clinically stable or exacerbation was good for <i>Pseudomonas aeruginosa</i> (84.8%) but poorer for other genera. (sensitivity 75% specificity 75.6% PPV 54.5% NPV 88.6%). <b>Conclusions:</b> Collecting sputum when clinically stable may helpful for sputum guidance for exacerbation if the colonized sputum pathogens were <i>Pseudomonas aeruginosa</i>.
On death and dying
Authors: E. Kubler-Ross
Journal: JAMA (1972)

Dr. J. Russell Little, Chief, Division of Infectious Disease, the Jewish Hospital of St. Louis and Associate Professor of Medicine and Microbiology, Washington University School of Medicine: Our guest this morning is Elisabeth Kübler-Ross, MD. Dr. Ross has become something of a celebrity since the feature story in<i>Life</i>magazine (Nov 21, 1969, p 36) concerning her and her work and the appearance of her recent book entitled<i>On Death and Dying</i>.<sup>1</sup>The book provides a fascinating account of an experiment in teaching and therapy concerned with the emotional problems of seriously ill and dying patients. We have decided to dispense with the traditional case presentation today even though Dr. Ross could discuss any of our hospitalized patients with a terminal disease. Instead we shall turn over the entire hour to her discussion of her approach to the emotional problems of dying patients. Dr. Elisabeth Kübler-Ross, Medical Director, South
Enteric dysmotility/acquired chronic intestinal pseudoobstruction (ED/CIPO)-relationship between small intestinal manometric and neurohistopathological findings
Authors: A. T. M. D. H. Chowdhury, A. Raimundo, A. Darzi, J. E. Martin, D. Silk
Journal: Gut (2011)

<h3>Introduction</h3> Enteric dysmotility is an important clinical subgroup of the gastrointestinal neuromuscular disorders.1 Of a personal series of 130 patients recorded on our data base 89 have undergone both 24 h ambulatory studies of small intestinal motility and laparoscopic full thickness jejuna biopsies. The aim of the present study was to examine the relationship between the manometric and neurohistopathological findings. <h3>Methods</h3> Prospective qualitative analysis of small intestinal motility tracings and abnormalities of 15 parameters of phasic activities of the intestinal interdigestive Migrating Motor Complex (IMMC) together with the occurrence of nocturnal abdominal pain during the study were documented. Neurohistopathological analysis of the full thickness biopsies was performed as previously described.2 <h3>Results</h3> All the small intestinal motility studies were abnormal 83 of 89 full thickness biopsies (93.3%) were abnormal. 51 (57.3%) α actin epitope deficiency alone, 26 (29.2%) α actin epitope deficiency with other pathology, 6 (6.7%) other pathology alone. Nocturnal abdominal pain was significantly related to the presence of vasculitis (p &lt;0.05) and smooth muscle atrophy (p &lt; 0.05). Sustained uncoordinated phasic pressure activity and discrete cluster contractions were both related to myenteric plexus pathology (p&lt;006, p&lt; 0.04). Aberrant phase III MMC configuration was related to smooth muscle biopsies (p&lt;0.003) and smooth muscle atrophy (p&lt;0.05) as well as vasculitis (p&lt;0.05). A reduction in numbers of phase III MMC was related to vasculitis (p&lt;0.007) and smooth muscle atrophy (p&lt;0.007). Generalised low pressure activity was related to amyloid deposition (p&lt;0.002) and lack of fed pattern to the deposition of amphophilic bodies (p&lt; 0.03). <h3>Conclusion</h3> The present findings suggest that abnormal small intestinal manometry is a good indicator of the presence of underlying neuromuscular pathology. Patients suspected of having ED/CIPO with abnormal manometry should undergo laparoscopic full thickness biopsies.
Handling of epidermal growth factor and number of epidermal growth factor receptors are changed in aged male rats
Authors: U Marti
Journal: Hepatology (1993)

In the aged liver, cell proliferation and induction of DNA synthesis by epidermal growth factor is impaired. Changes in the hepatic handling of epidermal growth factor may be important for these effects. I compared epidermal growth factor handling in the livers of young and old rats. Epidermal growth factor binding capacity of plasma membranes was reduced from 1.30 ± 0.15 to 0.51 ± 0.19 pmol/mg in young and old animals, respectively. Intracellular handling of epidermal growth factor was assessed by means of portal injection of 125I-labeled epidermal growth factor and collection of bile samples. The extraction of epidermal growth factor showed no significant difference. After 60 min the remaining radioactivity in the aged liver was half that in young liver. The total radioactivity secreted into bile was reduced from 16.5% ± 5.7% to 10.0% ± 2.3% of the injected dose in young and old animals, respectively. Per gram of liver and per 106 cpm injected, the old animals secreted only 30.9% of the amount secreted by young animals. The secretion of immunologically intact epidermal growth factor into bile was reduced from 1.6% ± 0.8% to 0.78% ± 0.2% of the injected dose in the young and old animals, respectively. Perfusion experiments showed that in aged liver the amount of total radioactivity secreted into the perfusate was increased to 133.6% that of the young liver. Per gram of liver and per 106 cpm injected, however, we found a reduction to 80.7%. Exocytosis at the canalicular and basolateral membrane appeared to be differently affected by aging. (HEPATOLOGY 1993;18:1432–1436.)
Asthma after consumption of snails in house-dust-mite-allergic patients: a case of IgE cross-reactivity
Authors: R. van Ree, L. Antonicelli, J. H. Akkerdaas, G. B. Pajno, G. Barberio, L. Corbetta, G. Ferro, M. Zambito, M. S. Garritani, R. C. Aalberse, F. Bonifazi
Journal: Allergy (1996)
Transactions of the Colorado State Medical Society held in Denver, June, 1884.
Authors: None C. E. W.
Journal: JAMA (1884)

These transactions show a commendable activity on the part of the profession in Colorado. A paper by S. E. Solly, M.D., on the influence of the local climate on Bright's disease presents as its chief physiological points, the fact that the urine in that dry region is somewhat concentrated, and as its conclusions " That acute nephritis is not especially induced by the climate, but having arisen, is in its onset aggravated by it," and respecting chronic nephritis, that the tendency of the climate is toward its cure. He does not consider that either of these propositions is fully established. The climatic charts, two for each of the four seasons of the year, 1882, show respectively the absolute humidity in grains to the cubic foot of air and mean cloudiness in tenths, for the whole country. They are issued by the society and published at its suggestion and expense by the
Erratum for the Research Article: “Wireless, battery-free, flexible, miniaturized dosimeters monitor exposure to solar radiation and to light for phototherapy” by S. Y. Heo, J. Kim, P. Gutruf, A. Banks, P. Wei, R. Pielak, G. Balooch, Y. Shi, H. Araki, D. Rollo, C. Gaede, M. Patel, J. W. Kwak, A. E. Peña-Alcántara, K.-T. Lee, Y. Yun, J. K. Robinson, S. Xu, J. A. Rogers
Journal: Science Translational Medicine (2019)
Changes over time in the knowledge base of practicing internists
Authors: P. G. Ramsey
Journal: JAMA (1991)

<h3>Objective.</h3> —To determine factors affecting the knowledge base of practicing internists. <h3>Design.</h3> —An 82-item multiple-choice examination with questions from the 1988 American Board of Internal Medicine (ABIM) certifying examination was used to assess the knowledge base of 289 internists. <h3>Setting and Participants.</h3> —Participants were selected from among practicing internists in New York, New Jersey, and Pennsylvania who had received ABIM certification 5 to 15 years previously. <h3>Results.</h3> —A significant inverse correlation (<i>r</i>= -.30) was found between examination scores and the number of years elapsed since certification. Knowledge declined sharply within 15 years of certification. In addition, procedure-oriented subspecialists (cardiologists and gastroenterologists) had lower scores than other internists in this examination of general medical knowledge. Multivariate analyses showed that independent variables that predicted test performance were initial ABIM certifying examination score, time elapsed since certification, subspecialty classification, medical school type, and residency type. <h3>Conclusions.</h3> —These results support the recent decision for time-limited certification of internists and raise questions related to content and standard setting for recertification examinations. (<i>JAMA</i>. 1991;266:1103-1107)
Oral Surgery. A Text-Book on General Medicine and Surgery as Applied to Dentistry.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effect of intervention on a quality measure of pain management at Medstar Washington Cancer Institute.
Authors: Vishal Navnitray Ranpura, Puja Chokshi, Charan Yerasi, Sundeep Agrawal, Lynne Wood, Jaylon Harkness, Linda Self, Sekwon Jang
Journal: Journal of Clinical Oncology (2014)

218 Background: Appropriate cancer pain documentation is one of the quality indicators in American Society of Clinical Oncology (ASCO)’s Quality Oncology Practice Initiative (QOPI). Medstar Washington Cancer Institute (MWCI) has participated in QOPI since 2008. Documentation of plan of care for moderate/severe pain defined as a pain score of ≥4 on a numeric pain scale was 69%, (compared to QOPI aggregate of 79%) during the fall 2011 round which led to a quality improvement project with an aim of ≥ 90%. Methods: MWCI created a team of physicians, nurses and administrative staff. We attended ASCO’s quality training workshop from October 2013 to March 2014 for guidance. We implemented a Plan Do Study Act (PDSA) methodology for our quality improvement project. We created a process map, cause and effect diagram and Pareto chart based on survey of physicians citing common reasons for lack of documented plan of care for pain. Results: Baseline rate of documented plan of care for pain control in November 2013 was 70%. In January 2014, we implemented action plans to increase the awareness of pain documentation (Electronic Health Record (HER) trigger for pain ≥ 4, fellows and mid level education and faculty consensus on documenting management for pain unrelated to cancer). After intervention, the pain documentation rate was improved to 90.2% (Table). Conclusions: After one cycle of PDSA, we achieved our goal of pain documentation rate. In order to sustain our project, we will continue to monitor the pain documentation rate quarterly in 2014 and continue the process of education and orientation to new staff as well rotating residents and fellows. [Table: see text]
The use of Doppler flow studies in the diagnosis of giant cell arteritis. Selection of temporal artery biopsy site is facilitated
Authors: J. Barrier
Journal: JAMA (1982)

Sixty patients, for whom a diagnosis of giant cell arteritis (GCA) was clinically suspected, underwent Doppler study as a method of guiding temporal artery biopsy. In group A (23 patients with normal Doppler results), only one had a positive histological lesion. In group B (14 patients with discrete Doppler abnormalities), none had inflammatory lesions. Twelve of the 23 patients in group C (stenosis or thrombosis) had a biopsy result corresponding to GCA. Forty-three percent of the patients in group C had degenerative arterial lesions leading to a decrease in blood flow. There is a small probability, according to this preliminary study, of diagnosing GCA by artery biopsy even when findings from the ultrasonic examination are normal or only slightly irregular. However, a negative Doppler result should in no case exclude a biopsy if the clinical picture is suggestive. (<i>JAMA</i>1982;248:2158-2159)