tbuckley/cabot-search huggingface dataset:
Medicolegal
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
FireMaster BP-6: Fractionation, Metabolic and Enzyme Induction Studies
Authors: S. Safe, J. Kohli, A. Crawford
Journal: Environmental Health Perspectives (1978)

FireMaster BP-6 is a commercial polybrominated biphenyl (PBB) preparation containing a complex mixture of isomers with the major component being identified as 2,2',4,4',5,5'-hexabromobiphenyl. Column chromatographic techniques have been developed in which the crude FireMaster is separated into three fractions, F1, F2, and F3, in increasing order of polarity. F1 consists of highly purified 2,2',4,4',5,5'-hexabromobiphenyl (94%) whereas F2-F3 contain less of this isomer and correspondingly more of the other bromobiphenyl components. Previously we have shown that crude FireMaster BP-6 is metabolized in mammals to give hydroxylated degradation products and the metabolism of F1, not unexpectedly, gives comparable results. It is well known that PBBs are effective inducers of diverse microsomal enzymes including including the aryl hydrocarbon hydroxylase (AHH) system. The effects of FireMaster BP-6 and F1-F3 as AHH inducers have been investigated by using the following approach: the substrates used to monitor AHH activity are model halogenated aromatic compounds; the levels of metabolites and metabolite conjugates formed have been quantitated for control and induced enzymes; the levels of macromolecular adducts have also been quantitated for the inducers. This approach thus not only measures the rate of increase of detoxification products (metabolites and metabolite conjugates) but also monitors the macromolecule adduct formation which represents a toxification route. The effects of the PBBs as AHH inducers will be discussed in terms of the above approach.
Effect of synchronized, systolic, lower body, positive pressure on hemodynamics in human septic shock. A pilot study.
Authors: J P Gunter, B P deBoisblanc, B S Rust, W D Johnson, W R Summer
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

The pathophysiologic disturbance observed in volume-resuscitated patients with septic shock is primarily that of hyperdynamic circulation with a markedly reduced systemic vascular resistance. We hypothesized that external, mechanically applied, phasic lower body positive pressure could increase systemic vascular resistance and, thus, blood pressure in patients with refractory septic shock. A total of nine studies were performed on seven patients with septic shock refractory to volume resuscitation and vasopressors. All pre-existing therapies were continued unaltered during the study period. Phasic lower body positive pressure was produced by rapid synchronized inflation of pneumatic fabric cuffs fitted around each lower extremity. The cuffs were inflated for 200 ms to a pressure of 150 mm Hg, and the timing of inflation was adjusted to coincide with the peak systolic arterial pressure. Hemodynamic measurements were obtained at baseline and after 15 min of phasic lower body positive pressure. This off-on cycle was repeated twice for each study. Phasic lower body positive pressure increased mean arterial pressure by 12% and cardiac index by 14% (p = 0.01) over baseline (p < or = 0.001). Heart rate, central venous pressure, pulmonary capillary wedge pressure, arterial pH, arterial pO2, and mixed venous pO2 were unchanged. Synchronized external systolic compression of the lower extremities increased mean arterial pressure and cardiac output in seven patients with refractory septic shock. This hemodynamic improvement was independent of changes in calculated systemic vascular resistance.
Abstract B56: A lineage-selective transcriptional pathway linking lung differentiation and cancer metastasis
Authors: William K.C. Cheung, Minghui Zhao, Zongzhi Liu, Paul D. Cao, Laura E. Stevens, Thomas F. Westbrook, Don X. Nguyen
Journal: Cancer Research (2013)

Abstract Lung cancer is the leading cause of cancer-related deaths worldwide. This poor prognosis is due to the rapid metastatic progression of this disease, yet the mechanisms that govern lung cancer dissemination and colonization are unclear. Through an integrated approach, we identified an alveolar cell-selective gene signature that stratifies lung adenocarcinoma (ADC) into molecular subtypes of distinct prognosis and differentiation states. This transcriptional program is regulated in part by the cell fate transcription factors, GATA6 and HOPX, which are normally required for proper alveolar differentiation. In an experimental model, suppression of GATA6 and HOPX cooperatively enhances metastatic competence of lung ADC cells. Whole genome RNA sequencing reveals that this transcriptional network can modulate specific target genes and pathways involved in airway epithelial differentiation and invasion. Our findings identify a novel cell lineage molecular program whose perturbation enhances lung cancer metastasis. Citation Format: William K.C. Cheung, Minghui Zhao, Zongzhi Liu, Paul D. Cao, Laura E. Stevens, Thomas F. Westbrook, Don X. Nguyen. A lineage-selective transcriptional pathway linking lung differentiation and cancer metastasis. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Invasion and Metastasis; Jan 20-23, 2013; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2013;73(3 Suppl):Abstract nr B56.
Clinical measurement of systolic pressures in limbs with arterial occlusive disease
Authors: S. A. Carter
Journal: JAMA (1969)

Systolic pressures can be measured easily in the limbs with arterial occlusive disease using blood pressure cuffs. Pulse pick-ups, ultrasonic flow detector, spectroscope, or visual "flush" technique may be used to detect the end point. Systolic pressures were measured in 202 limbs with angiographically documented arterial disease and in 86 control limbs. The pressures were abnormal in all limbs with complete proximal occlusion and in the majority of limbs with proximal stenosis. Such measurements are helpful in the evaluation of cases with doubtful arterial disease, in selection of patients for arterial surgery, in the objective assessment of the results of treatment, and in the follow-up of patients. The described techniques should find wide clinical application, particularly since the measurements can be carried out easily at bedside and in the physician's office.
Surveys and Symposia
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effects of low molecular weight heparin, alone or combined with antithrombin III, on mortality, fibrin deposits and hemostatic parameters in endotoxin‐induced disseminated intravascular coagulation in rabbits
Authors: J. Hermida, R. Montes, M.C. Muñoz, J. Orbe, J.A. Páramo, E. Rocha
Journal: American Journal of Hematology (1999)

The effect of low molecular weight heparin (LMWH) with or without antithrombin III (AT III) has been studied in a rabbit model of disseminated intravascular coagulation (DIC) induced by continuous infusion of 100 µg/kg/hr of Escherichia coli endotoxin for 6 hr.LMWH (5 and 10 IU/kg/hr/6 hr), alone or in combination with AT III (20 U/kg/hr/6 hr), or saline were administered simultaneously with endotoxin.Hemostatic markers at 0, 2, and 6 hr as well as kidney fibrin deposits and the mortality rate at 24 hr were determined.Rabbits receiving only endotoxin showed an impairment in hemostasis, as well as high kidney fibrin deposits and a high mortality rate.LMWH alone did not exert any effect.The simultaneous infusion of LMWH and AT III exerted a beneficial effect on the hemostatic markers and reduced the kidney fibrin deposits as well as the mortality rate in a LMWH dose-dependent manner.Fibrinogen and protein C consumption were significantly higher and renal fibrin deposits more intense in the rabbits that had died in the first 24 hr.There was also a significant positive correlation between kidney fibrin deposits and platelets, fibrinogen, and protein C consumption, taking the whole rabbit population.It is concluded that the simultaneous infusion of LMWH and AT III is useful in this DIC model and would make it possible to reduce significantly the AT III doses used when AT III is given alone.Am.
Modern Treatment
Authors: H. M. Flanagan
Journal: BMJ (1953)

A proposal to allow prisoners to save their lives or to be eligible for commutation of sentence by donating kidneys for transplantation has been a subject of controversy in the Philippines. Notwithstanding the vulnerabilities associated with imprisonment, there are good reasons for allowing organ donations by prisoners. Under certain conditions, such donations can be very beneficial not only to the recipients but to the prisoners themselves. While protection needs to be given to avoid coercion and exploitation, overprotection has to be avoided. The prohibition on the involvement of prisoners in organ transplantation constitutes unjustified overprotection. Under certain conditions, prisoners can make genuinely independent decisions. When it can be reasonably ascertained that they are able to decide freely, society should recognise an obligation to help them implement their decisions, such as when they intend to donate an organ as a way of asserting their religious faith and performing a sacrifice in atonement for their sins.
PWE-038 Influence of postoperative morbidity on longterm cancer survival after oesophagogastric surgery
Authors: A Eltweri, S Satheesan, S Ubhi, D Bowrey
Journal: Gut (2012)

<h3>Introduction</h3> Previous studies have shown that postoperative adverse events after colorectal resection predict a poor prognosis with early cancer relapse. The aim of this study was to report the outcome of patients undergoing oesophagogastric resection to assess the influence of in-hospital factors on longterm cancer survival. <h3>Methods</h3> Retrospective review of patients undergoing oesophagogastric resection for carcinoma during the years 2006–2010 at our institution. Minimum follow-up of 12 months was required. <h3>Results</h3> The study population was 164 patients (110 male) of median age 64 years (range 32–84). 84 underwent oesophagectomy, 80 gastrectomy. 99 received neoadjuvant chemotherapy. The 90-day, 1-year and 3-year survivals were 92%, 84% and 49% respectively. 69 patients (42%) developed postoperative complications (commonest: pneumonia 19%, anastomotic leak 7%, wound infection 6%). None of tumour site (oesophagus vs stomach, p=0.73), length of ITU stay (&lt;3 days vs &gt;3 days, p=0.50) or development of postoperative complications (p=0.70) influenced longterm prognosis. The only two factors that influenced longterm outcome were UICC stage (p&lt;0.001) and circumferential resection margin (positive vs negative, p&lt;0.001). <h3>Conclusion</h3> Patients experiencing postoperative morbidity can expect the same longterm oncologic outcome as those not suffering these early setbacks. <h3>Competing interests</h3> None declared.
Part 3: Abstracts From the NCCN 19th Annual Conference: Advancing the Standard of Cancer Care™
Authors: Palak Patel, Surbhi Shah, Khawar Siddiqui, Amani Al-Kofide, Rafat Jafri, Asim Belgaumi, Daniel Pryma, Daniel Sullivan, Camilo Jimenez, Julie Schwarz, Richard Noto, Thomas Armor, John Babich
Journal: Journal of the National Comprehensive Cancer Network (2014)

Background: Prostate cancer continues to represent a major source of medical expenditure.As the health care delivery costs continue to increase along with the rates of diagnosis and survival, increased attention must be paid to the patient's expenditure.The main purpose of this study is to analyze trends in total expenditure in patients with prostate cancer from 2006 to 2010.Because prostate cancer is highly prevalent in black men, the secondary objective of this study is to evaluate the total expenditure in prostate cancer based on race.Methods: A longitudinal retrospective database analysis was performed from 2006 to 2010 using Medical Expenditure Panel Survey data.Various files, such as medical condition; prescription drugs; outpatient, inpatient, and emergency visits; office-based and home health care; and full-year consolidated files were combined and analyzed when patients with prostate cancer were identified using Clinical Classification Code 29.Descriptive statistics were used to assess trends, whereas domain analysis was used to estimate expenditure based on race.Results: Total expenditure in patients with prostate cancer was found to be approximately $3.7 billion in 2006, followed by approximately $12.0 billion in 2007, $5.7 billion in 2008, $7.4 billion in 2009, and nearly $5.6 billion in 2010.Thus, the expenditure was inconsistently reduced after 2007.Results of domain analyses showed that, on average, white patients spent more on health care than black patients in all years except 2007.Conclusions: Prostate cancer expenditure was found to be higher in 2007.The literature has reported that overuse of health care services among patients with prostateThe following abstracts were accepted for presentation at the
<i>QuickStats:</i> Age-Adjusted Death Rates* from Female Breast Cancer,† by State — National Vital Statistics System, United States,§ 2017
Journal: MMWR Morbidity and Mortality Weekly Report (2019)

Abbreviation: DC = District of Columbia.* Data were age-adjusted to the 2000 U.S. standard population.† Breast cancer deaths were those with International Classification of Diseases, Tenth Revision underlying cause of death code C50.§ The U.S. death rate for female breast cancer was 19.9 per 100,000 population in 2017.In 2017, the overall age-adjusted death rate for female breast cancer was 19.9 per 100,000 population.The highest death rates were in Mississippi (25.5),DC (24.3), and Louisiana (23.6).The lowest death rates were in Hawaii (15.6), Alaska (16.3),New Hampshire (16.3),Wyoming (16.5),Rhode Island (16.6), Minnesota (16.7),South Dakota (17.3),Wisconsin (17.4), and Vermont (17.4).
Error in Collaborator Name
Authors: Jeffrey Swanson, Richard Bonnie, Paul Appelbaum
Journal: JAMA (2016)

Ildiko Lingvay, MD, MPH, MSCS; Federico Pérez Manghi, MD; Pedro García-Hernández, MD; Paul Norwood, MD; Lucine Lehmann, MD; Mads Jeppe Tarp-Johansen, PhD; John B. Buse, MD, PhD; for the DUAL V Investigators
Study of Incidence and Characteristics of Blood Donor Reactors
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Neurosurgery
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE ETIOLOGY OF ECZEMA.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
DISCRIMINATING AMONG DISCRIMINANTS IN ADVANCED BREAST CANCER
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal