tbuckley/cabot-search huggingface dataset:
Magnetic resonance imaging of the cardiovascular system. Present state of the art and future potential. Council on Scientific Affairs. Report of the Magnetic Resonance Imaging Panel
Journal: JAMA (1988)

State-of-the-art magnetic resonance imaging (MRI) generates high-resolution images of the cardiovascular system. Conventional MRI techniques provide images in six to ten minutes per tomographic slice. New strategies have substantially improved the speed of imaging. The technology is relatively expensive, and its cost-effectiveness remains to be defined in relation to other effective, less expensive, and noninvasive technologies, such as echocardiography and nuclear medicine. The ultimate role of MRI will depend on several factors, including the development of specific applications such as (1) noninvasive angiography, especially of the coronary arteries; (2) noninvasive, high-resolution assessment of regional myocardial blood flow distribution (eg, using paramagnetic contrast agents); (3) characterization of myocardial diseases using proton-relaxation property changes; and (4) evaluation of in vivo myocardial biochemistry. The three-dimensional imaging capability and the ability to image cardiovascular structures without contrast material give MRI a potential advantage over existing noninvasive diagnostic imaging techniques. This report analyzes current applications of MRI to the cardiovascular system and speculates on their future.
Relationship between electrical and hemodynamic parameters using bi-ventricular and uni-ventricular pacing in heart failure patients Randy Lieberman, Wisam Martini, Raghava Velagaleti, Suneet Kukreja, Srinavasa Madala, Kathryn E. Hilpisch, Michael R. S. Hill. Wayne State University and Harper Hospital, Detroit, MI
Journal: Journal of the American College of Cardiology (2001)
The illness process. Psychosocial hazards of disability programs
Authors: M. R. Weinstein
Journal: JAMA (1968)

Recent studies of disability following industrial accidents illustrate an "accident process" in which social and emotional conflicts are resolved by substituting the "acceptable" disability of injury for the "unacceptable" disability of tension and depression. Aid to the Needy Disabled and other disability programs can become part of an analogous "illness process" in which medical impairment becomes the "acceptable" solution to a patient's longstanding conflicts in living. When disability programs serve this purpose, they vitiate efforts to reduce the social and emotional tensions which really disable the patient. Physicians can be trained to elicit and interpret the information necessary to understand the development of the "illness process." Health professionals must learn how to help patients find less costly ways of coping with conflict than through the pseudosolution of chronic disability.
Privacy and dignity are lacking on children's wards
Journal: BMJ (1999)

Nicotine nasal spray with patch is effective in stopping smoking On p 285 Blondal et al evaluate the efficacy of using a nicotine patch for 5 months with a nicotine spray for 1 year in stopping smoking.After 1 year, 27% of participants using the combined treatment were abstinent compared with 11% in the patch only group.Having access to nicotine in the nasal spray probably alleviated smoking urges.Five years after stopping treatment the difference in abstinence rates was double, emphasising the benefits of the combined treatment.
THE EPIDEMIOLOGY OF MALARIA.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An Exercise in Futility
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Obituary
Authors: Franklin S. Newell, Frederick C. Irving, Judson A. Smith, Arthur B. Donovan, Foster S. Kellogg, John Rock, Delos J. Bristol, Thomas R. Goethals, M. F. Eades, John B. Swift, Saul Berman, Paul Gustafson, Meinolph Kappius, William B. Young
Journal: New England Journal of Medicine (1930)
The Hysteria of Lady Macbeth.
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ADDRESSES.
Journal: JAMA (1890)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effect of ethanol on rat fetal hepatocytes: Studies on cell replication, lipid peroxidation and glutathione
Authors: B Devi
Journal: Hepatology (1993)

Studies have shown that ethanol at moderate concentrations inhibits epidermal growth factor–dependent replication of fetal rat hepatocytes in culture. This may account for the growth/development impairment associated with fetal alcohol syndrome and decreased liver regeneration in alcoholic liver disease. In this study, we further define the mechanism(s) of the negative impact of ethanol on fetal rat hepatocytes and provide evidence that ethanol-induced injury to these cells is associated with membrane damage caused by lipid peroxidation, altered cell glutathione homeostasis and deranged mitochondrial structure and function. Exposure of fetal rat hepatocyte replication to ethanol (2 mg/ml) promptly resulted in blockade of replication, as indicated by a 40% reduction in DNA synthesis (p < 0.05). Assessment of cell injury on the basis of lactate dehydrogenase and ALT leakage indicated a statistically significant but not appreciable effect, whereas 51Cr leakage was more substantially increased (p < 0.05). Within 6 hr of ethanol exposure, superoxide radical levels increased more than twofold (p < 0.05). We noted a 56% increase in levels of diene conjugates, a 131% increase in malonaldehyde concentration and a 66% increase in fluorescent products of lipid peroxidation (all p < 0.05). Glutathione levels were decreased to 47% below control values (p < 0.05). Electron microscopic studies illustrated a slight disruption of mitochondrial structure (enlargement of mitochondria and dilation of cristae). This disruption was accompanied by mitochondrial swelling (increased permeability), altered mitochondrial membrane potential (a 16% decrease in rhodamine uptake), a 28% decrease in succinate dehydrogenase activity and a 30% decrease in cellular ATP level (p < 0.05). Pretreatment of fetal rat hepatocytes with 0.1 mmol/L N-acetylcysteine or S-adenosylmethionine for 24 hr prevented the ethanol-induced reduction of ATP and glutathione levels, essentially restored cell replication, ameliorated 51Cr leakage and decreased malonal-dehyde and diene conjugate levels to 41% to 65% and 25% above control values, respectively. Pretreatment with 0.1 mmol/L vitamin E fully normalized malonal-dehyde and diene conjugate levels and 51Cr leakage but failed to improve ATP levels or to increase significantly cell replication and glutathione levels. Concomitant administration of glutathione precursors with ethanol, rather than pretreatment, did not alter the impaired cell replication. Thus our data underscore the importance of cellular glutathione and ATP in preventing ethanol-induced decreases in fetal cell replication and suggest that alleviation of cellular lipid peroxidation alone is not sufficient to prevent this abnormality in fetal rat hepatocyte function. (HEPATOLOGY 1993;18:648–659.)
Interaction of Alkylmercuric Compounds with Sodium Selenite. III. Biotransformation, Levels of Metallothioneinlike Proteins and Endogenous Copper in Some Tissues of Rats Exposed to Methyl or Ethylmercuric Chloride with and without Sodium Selenite
Authors: Elzbieta A. Brzeznicka, Jadwiga Chmielnicka
Journal: Environmental Health Perspectives (1985)

The biotransformation efficiency of alkylmercurial compounds was studied in rat liver, kidneys, blood, and brain after 2-week administration of methylmercuric chloride (MeHg) and ethylmercuric chloride (EtHg) at doses of 0.25 or 2.5 mg Hg/kg, alone or in combination with sodium selenite (Se) at a level of 0.5 mg Se/kg.Simultaneously, the level of metallothioneinlike proteins (MTP) and endogenous copper (Cu) was monitored in tissues of control rats and intoxicated rats.Regardless of the dose, the highest concentrations of inorganic mercury from both the alkylmercurials was found in the rat kidneys.Sodium selenite had a variable effect on the amount of inorganic mercury liberated, depending on the organ and the molar ratio of Hg:Se administered.A statistically significant increase in the levels of MTP and endogenous Cu, compared with control group, was found only in the kidneys of intoxicated rats.This increase was dependent on the concentration of inorganic mercury liberated by biotransformation of alkylmercurials.The observed changes appeared when the level of inorganic mercury exceeded 10,Ig Hg/g tissue and reached a plateau at about 40 ,ug Hg/g tissue.In the presence of selenium the plateau of MTP and Cu levels were no oberved in the kidneys, regardless of the amount of inorganic mercury liberated.
THE DEGENERATE JAWS AND TEETH.
Authors: EUGENE S. TALBOT
Journal: JAMA (1896)

Next to the ears, the jaws and teeth (as was to be expected from the variability of these organs in allied animals), are most affected by degeneracy. This is particularly true of the vertebrates; especially the mammals, as might have been anticipated from their phylogeny or line of descent. At the head of the vertebrates is man; at the foot is the lancelet (<i>amphioxus</i>), most akin to those semi-vertebrates the ascidians, who, in their larval phase, are higher than when adult and whose life history excellently illustrates that potent phase of evolution, degeneracy.<sup>1</sup> The lancelet<sup>2</sup>has a spinal cord inclosed in a soft semi-cartilaginous canal (the notochord). It is practically destitute of a brain. The cerebral vesicle which represents this, is a plain cavity without true subdivision into ventricles. There is no cranium and the median eye is a mere pigment spot with which it is able to
Predictive value of microalbuminuria in longstanding insulin dependent diabetes: Authors' reply
Authors: L. Groop, C. Forsblom, P.-H. Groop, A. Ekstrand
Journal: BMJ (1993)

Estimnated progressioni of mticroalbuminuria in three patienits with differenit duirationis ofdiabetes Duration of Estimated excretion Estimated time diabetes Excretion rate rate at from entrv to overt at entry at entry Estimated annual rate follow up nephropathy (years) (mg/24 h) of increase (¼) (mg/24 h) (years) 16 75 12
Correction
Authors: D Morley, J O'reilly, S Raiti, R Robinson, Patricia Russell, J Scopes, A Skynner, Pamela Zinkin, Sheila Anderson, E Battersby, H Blades, W Glover, Dorothea Halstead, Margaret Hawksley (anaes'thetics), R Brown, D Cottom, A Jackson, Ursula Shelley, R Hoare, C Hodson, A Chrispin, J Lillie, J Sutcliffe, B Ward, J Wilson, Mr Edward, Mr Keith, E Moynahan, J Pegum, Barbara Ockenden, J Wigglesworth, J Pearce
Journal: BMJ (1969)
Accuracy of the x-ray report
Authors: C. A. Stevenson
Journal: JAMA (1969)

In the early days of diagnostic roentgenology, pioneers often were disheartened when they realized that their diagnoses were more often wrong than right. The time between World Wars I and II saw the specialty develop from a crude science to an indispensable part of medical diagnosis. This period was characterized by fundamental studies establishing the roentgen criteria for diagnosis of many disease processes. As roentgenologic reports became more accurate and reliable, physicians relied increasingly on this diagnostic method and the volume of examinations grew at an astounding rate. In spite of this rapid advance and acceptance, serious students of the specialty began to question the specificity of certain roentgen findings and, in the 1930's and 1940's, became aware that instead of 3 or 4, as many as 100 or more different etiologic agents could produce somewhat similar roentgen findings in the lung fields. During this same period, variations and inconsistencies
Response to Repeated Platelet Transfusions from the Same Donor
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Surgical repair of complete acromioclavicular separation
Authors: J. P. Ahstrom
Journal: JAMA (1971)

Proper strength, endurance, and motion after acromioclavicular separation are dependent upon maintenance of proper reduction until strong ligamentous healing can occur. This is best accomplished by open reduction of the joint, removal of debris from the joint cavity, strong temporary internal fixation, and provision for proper ligamentous reinforcement or reconstruction. This last feature is provided by turning the tendon of the short head of the biceps proximal-ward and suturing it to the clavicle. This reinforces any healing which can be accomplished by the original ligaments and replaces them altogether if the injury is old. There is no chronologic age limit for this procedure which achieves the desired objectives and enables the patient to be comfortable and useful during his convalescence. The 15 cases reviewed had follow-up periods as long as 73 months.
Malabsorption Syndrome
Authors: Marvin H. Sleisenger
Journal: New England Journal of Medicine (1969)

IN recent years the malabsorption syndrome in man has been more clearly defined and hence more easily recognized. Biochemical and histologic approaches to diagnosis and therapy, based on the physiology of breakdown and transport of foodstuffs, water and minerals, are increasingly used. This report will review the malabsorption syndrome with special reference to the pathophysiologic basis for signs, symptoms and treatment.Clinical PictureThe malabsorption syndrome is characterized by weight loss, anorexia, abdominal distention, borborygmi, muscle wasting and the passage of abnormal stools, which are usually light yellow to gray, greasy and soft and, in many cases, bulky, with a . . .
Fever of unknown origin
Authors: W. R. Barclay
Journal: JAMA (1977)

One of the most difficult challenges in clinical medicine is arriving at a specific diagnosis for a fever of unknown origin (FUO). The cause of a FUO will frequently remain obscure and frustrate the best diagnostic efforts of an aggressive house staff backed up by learned consultants and a medical center equipped with the latest and most sophisticated diagnostic facilities. The FUOs can be divided into four groups on the basis of their underlying cause: (1) infections, (2) neoplasms, (3) collagen-vasculitis disorders, and (4) miscellaneous (eg, sarcoid). In the most difficult and obscure cases, the clinician may not be able to assign the cause of a FUO to one of these groups and may be reluctant to initiate a trial of corticosteroid therapy for what is believed to be a vasculitis, in case an infection such as tuberculosis is the real villain. Thus, patients with FUO are subjected to a
Adolescent medicine
Authors: M. D. Wilson
Journal: JAMA (1995)

During the past few decades, the health status of adolescents in this country has been declining. Major causes of morbidity and mortality during the second decade of life are behavioral and psychosocial rather than purely biomedical. Hence, the salient issues for adolescent health relate predominately to violence and injuries (intentional and unintentional), substance use, and the consequences of unprotected sexual activity: unintended pregnancies and sexually transmitted infections, including human immunodeficiency virus and acquired immunodeficiency syndrome. Despite increased attention, violence continues to cause major health problems for adolescents. Several large-scale surveys of adolescents underscore the extent of violence and its impact on adolescents' emotional health. In a telephone survey of a nationally representative sample of children and adolescents aged 10 to 16 years, one fourth of respondents reported having experienced an assault or abuse (victimization) in the previous year.<sup>1</sup>Victimization included assault by nonfamily or a family member, kidnapping, sexual
JAMA Instructions for Authors
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pharmacokinetics Of Recombinant Factor VIII Fc Fusion Protein (rFVIIIFc) in Pediatric Subjects With Hemophilia A: An Interim Analysis Of The Kids A-LONG Study
Authors: Guy Young, Johnny Mahlangu, Beatrice Nolan, Simon Brown, Leonard A. Valentino, Raina Liesner, Yingwen Dong, Lei Diao, Haiyan Jiang, Karen Nugent, Glenn F. Pierce, Geoffrey Allen
Journal: Blood (2013)