tbuckley/cabot-search huggingface dataset:
National Health Service
Authors: E. Graham-Little
Journal: BMJ (1948)

Podocyte loss is a major determinant of progressive CKD. Although recent studies showed that a subset of parietal epithelial cells can serve as podocyte progenitors, the role of podocyte turnover and regeneration in repair, aging, and nephron loss remains unclear. Here, we combined genetic fate mapping with highly efficient podocyte isolation protocols to precisely quantify podocyte turnover and regeneration. We demonstrate that parietal epithelial cells can give rise to fully differentiated visceral epithelial cells indistinguishable from resident podocytes and that limited podocyte renewal occurs in a diphtheria toxin model of acute podocyte ablation. In contrast, the compensatory programs initiated in response to nephron loss evoke glomerular hypertrophy, but not <i>de novo</i> podocyte generation. In addition, no turnover of podocytes could be detected in aging mice under physiologic conditions. In the absence of podocyte replacement, characteristic features of aging mouse kidneys included progressive accumulation of oxidized proteins, deposits of protein aggregates, loss of podocytes, and glomerulosclerosis. In summary, quantitative investigation of podocyte regeneration <i>in vivo</i> provides novel insights into the mechanism and capacity of podocyte turnover and regeneration in mice. Our data reveal that podocyte generation is mainly confined to glomerular development and may occur after acute glomerular injury, but it fails to regenerate podocytes in aging kidneys or in response to nephron loss.
Tularemia’s Coastal Creep
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Iatrogenic Malformations
Authors: S VAAGE, J BERCZY
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Religious investors ask health/hygiene products giant to 'kleen' out of the tobacco business
Authors: A. A. Skolnick
Journal: JAMA (1995)

TWO RELIGIOUS groups that own a large number of shares in Kimberly-Clark Corporation are asking the manufacturer of health, hygiene, and hospital products to get out of the tobacco business. The groups, the Congregation of the Sisters of Charity of the Incarnate Word, in Houston, Tex, and the Redemptorists of St Louis, Mo, are sponsors of a shareholder resolution calling on the company's management to "spin-off all tobacco business." <h3>Tobacco Program Project</h3> In addition to the 70000 company shares owned by the two groups, hundreds of thousands of additional shares are owned by other religious organizations that are members of the Interfaith Center on Corporate Responsibility (ICCR), New York, NY. As part of its Tobacco Program Project, the center has been conducting a "Kleen Out Tobacco From Kimberly-Clark" campaign to persuade the corporation to retire from the tobacco business, says ICCR's executive director Timothy Smith. Well known for its popular
CHLORACNE
Authors: K. D. Crow
Journal: British Journal of Dermatology (1970)

Journal Article CHLORACNE Get access K. D. Crow K. D. Crow Princess Margaret Hospital Swindon Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 83, Issue 5, 1 November 1970, Pages 599–600, https://doi.org/10.1111/j.1365-2133.1970.tb15749.x Published: 01 November 1970
AUTO-NEPHROTOXINS IN OPERATIONS UPON THE KIDNEYS.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prognostic value of clotting and fibrinolytic systems in a follow-up of 165 liver cirrhotic patients
Authors: Francesco Violi, Domenico Ferro, Stefania Basili, Claudio Cimminiello, Mirella Saliola, Edoardo Vezza, Corrado Cordova, The Calc Group
Journal: Hepatology (1995)

One hundred sixty-five patients with cirrhosis diagnosed by needle liver biopsy were followed for 2 years to evaluate the relation between clotting factors and survival. Patients with spontaneous bacterial peritonitis, hepatic carcinoma, and cholestatic liver diseases were excluded. Patients were classified as A (n = 34), B (n = 75), or C (n = 56) according to Child-Pugh criteria. During the follow-up 45 patients died of liver failure or gastrointestinal hemorrhage. Nonsurvivor patients had significantly higher values of bilirubin and D-dimer, a marker of fibrinolysis in vivo, lower values of albumin, prothrombin activity, fibrinogen, prekallikrein, factor VII, and a more prolonged activated partial thrombo-plastin time than survivors. All these variables and Child-Pugh classification were significantly associated with survival in a univariate analysis. Multivariate analysis (Cox's model) showed that only prekallikrein and factor VII were independently predictors of survival. Ninety-three percent of patients with prekallikrein values &lt;32% died within 32 months of follow-up, whereas factor VII &lt;34% identified 93% of patients who died within 10 months of follow-up. This study suggests that factor VII is an early predictor of survival and may be a useful test to better identify cirrhotic patients who should be candidates for liver transplantation. (Hepatology 1995 22: 96-100.)
TREATMENT OF PARAPLEGIA RESULTING FROM TRAUMA TO THE SPINAL CORD
Authors: L. W. FREEMAN
Journal: JAMA (1949)

<h3>4. Blood.—</h3> As already indicated, the first weeks after spinal cord injury are marked by an extremely abnormal blood picture. In the first twenty-four hours there begins a series of poorly understood changes. Serum protein begins to fall sharply, followed later by a drop in hemoglobin, and later by a decrease in red blood cells. At the end of the first week, the serum protein may reach levels below 5.0 Gm. per hundred cubic centimeters, the hemoglobin below 10 Gm. per hundred cubic centimeters and the red blood cells below 3,500,000 per cubic millimeter. In the presence of decubiti and bladder infection, these low levels are usually reached, and the albumin-globulin ratio is reversed. If decubiti are not present at this time, they are most likely to develop unless careful turning is carried out. It is far better to anticipate these changes by the administration of whole blood, calculated as 1 pint (473 cc.) for each 0.5 Gm. that
NEPHRECTOMY.
Authors: J. H. CARSTENS
Journal: JAMA (1898)

Formerly removal of the kidney was a most formidable operation as the mortality was from 85 to 90 per cent. It was only performed in the very last stages, as a<i>dernier ressort</i>. Diagnosis also being very difficult, the morbid conditions for which we now operate and remove the kidney, were treated by internal or external medications. But with the advent of aseptic surgery, great improvement has taken place, and the death record following operations has been so much lessened that, today, it is as low as the general run of operations involving the peritoneum. The technique has been simplified, so that today no abdominal surgeon hesitates to remove the kidney when indicated. <h3>Diagnosis.</h3> — The diagnosis of pathologic conditions requiring removal of the kidney is not easy, the symptoms in many cases being very obscure. Pain in the back is among the symptoms considered indicative of kidney troubles, and
ESGE news and upcoming events May 2021
Journal: Endoscopy (2021)

The ESGE Medtronic Research Award supports Artificial Intelligence (AI) research in the field of colonoscopy and we would like to encourage people to apply for our second application round. Winners will receive GI Genius systems, the number determined by the Award Committee on review of the successful award application plus direct costs will be covered up to a maximum total value of € 8,000 to the successful applicants’ institutions.
Mercury: Major Issues in Environmental Health
Authors: Thomas W. Clarkson
Journal: Environmental Health Perspectives (1993)

In the past, methylmercury compounds were manufactured as fungicides or appeared as unwanted byproducts of the chemical industry, but today the methylation of inorganic mercury in aquatic sediments and soils is the predominant if not the sole source of methylmercury. This form of mercury is bioaccumulated to a high degree in aquatic food chains to attain its highest concentrations in edible tissues in long-lived predatory fish living in both fresh and ocean waters. It is well absorbed from the diet and distributes within a few days to all tissues in the body. It crosses without hindrance the blood-brain and placental barriers to reach its principal target tissue, the brain. It is eliminated chiefly in the feces after conversion to inorganic mercury. The biological half-time of methylmercury in human tissues is about 50 days, but there is wide individual variation. Adult poisoning is characterized by focal damage to discrete anatomical areas of the brain such as the visual cortex and granule layer of the cerebellum. A latent period of weeks or months may ensue before the appearance of signs and symptoms of poisoning. The latter manifest themselves as paresthesia, ataxia, constriction of the visual fields, and hearing loss. The prenatal period is the most sensitive stage of the life cycle to methylmercury. Prenatally poisoned infants exhibit a range of effects from severe cerebral palsy to subtle developmental delays. Methylmercury is believed to inhibit those processes in the brain specially involved in development and growth such as neuronal cell division and migration.
Consequences of direct genetic testing for germline mutations in the clinical management of families with multiple endocrine neoplasia, type II
Authors: H. P. Neumann
Journal: JAMA (1995)

<h3>Objective.</h3> —Multiple endocrine neoplasia, type II (MEN-II) is an autosomal dominant disorder characterized by tumors of thyroid C cells and pheochromocytoma. Recently, germline mutations in the<i>RET</i>proto-oncogene have been identified in patients with MEN-II. The aims of this study were (1) to define the mutations in clinically diagnosed MEN-II families, (2) to compare the results of genetic and biochemical testing, and (3) to evaluate the impact of mutation analyses for the members of these families. <h3>Design.</h3> —Register-based survey study of clinically affected and unaffected members of MEN-II families. <h3>Setting.</h3> —Register of families from Germany and Spain with pheochromocytomas. Two research laboratories at Cambridge University in the United Kingdom. <h3>Patients.</h3> —We investigated consenting affected and unaffected members belonging to a series of 10 families who met the clinical criteria for MEN-II. <h3>Main Outcome Measures.</h3> —(1) Presence or absence of germline mutation in the<i>RET</i>proto-oncogene in affected and unaffected members of the 10 families, and (2) in the absence of<i>RET</i>mutation in a given family, presence or absence of germline mutation in the von Hippel-Lindau (<i>VHL</i>) gene, which is the susceptibility gene involved in a closely related syndrome, von Hippel-Lindau disease. <h3>Results.</h3> —In eight of these families,<i>RET</i>mutations were identified. The specific mutations were detected in all affected members. The remaining two families without<i>RET</i>mutations were subsequently shown to have a mutation within the<i>VHL</i>gene. The<i>VHL</i>mutations were identified in both families and represent a previously undescribed base change. After identification of the mutation, premorbid genetic testing was performed in all MEN-II and VHL families, resulting in detection of asymptomatic carriers in the MEN-II families. Clinically, the two VHL families differed from the eight MEN-II families by the presence of a C-cell tumor in only one individual from each family and extra-adrenal pheochromocytoma in three of nine affected individuals in the two families combined. <h3>Conclusions.</h3> —The diagnosis of MEN-II should be confirmed by molecular genetic analysis and the diagnosis of VHL syndrome should be considered for families with an absence of<i>RET</i>mutations and a preponderance of pheochromocytomas. (<i>JAMA</i>. 1995;274:1149-1151)
Autopsy Diagnosis and Technic
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Naked DNA Transfer of Factor VIII Induced Transgene-Specific, Species-Independent Immune Response in Hemophilia A Mice
Authors: P YE
Journal: Molecular Therapy (2004)

The development of antibodies to a previously unexpressed protein product may limit the success of human gene therapy approaches. We inserted B-domain-deleted factor VIII (FVIII) cDNA of human, canine, or murine origin into the multiple cloning site of a liver-specific vector, pBS-HCRHPI-A, to yield plasmids pBS-HCRHPI-FVIIIA, pBS-HCRHPI-cFVIIIA, and pBS-HCRHPI-mFVIIIA, respectively. Fifty micrograms of each plasmid in 2 ml of solution was rapidly injected into the tail vein of three groups of hemophilia A mice. Factor VIII levels ranging from 3 to 12 IU/ml were obtained from all three groups (normal is 1 IU/ml in human plasma) 3 days after treatment. These initial very high levels of functional human, canine, or murine factor VIII, however, fell gradually to undetectable levels within 2–3 weeks, and their disappearance correlated with the generation of high-titer, inhibitory anti-FVIII antibodies. Notably, this immune response occurred independent of the species of origin of the exogenous factor VIII. Antibody titers to factor VIII were detected beginning at 2 weeks, reached a plateau and remained at high levels for over 6 months. The majority of anti-hFVIII IgG was IgG1 isotype specific, suggesting a humoral response mediated by Th2-induced signals. Consistent with this idea, in a separate group of mice treated with pBS-HCRHPI-FVIIIA, transient immunosuppression by cyclophosphamide significantly delayed (5/6) or abolished (1/6) inhibitory antibody formation against the transgene.
Issue Highlights
Journal: Circulation (2004)

Morbidity and mortality are high in fetuses with isolated complete atrioventricular block (CAVB), often caused by maternal anti-Ro and anti-La autoantibodies that enter the fetal circulation and trigger immune-mediated inflammation of the atrioventricular nodal and myocardial tissues.Fetal CAVB was treated with maternal dexamethasone at CAVB diagnosis and ␤-stimulation for fetal heart rates Ͻ55 bpm.Cases treated with this protocol, compared with those who did not receive such treatment, had a lower rate of immune-mediated conditions (myocarditis, hepatitis, cardiomyopathy) resulting in postnatal death or heart transplantation.These data suggest that a standardized treatment approach including transplacental fetal administration of dexamethasone and ␤-stimulation at heart rates Ͻ55 bpm may reduce the morbidity and improve the outcome of isolated fetal CAVB.The safety and efficacy of this approach should be further tested in a prospective, randomized trial.See p 1542.
Methamphetamine Ingestion by a Breast-feeding Mother and Her Infant's Death: People v Henderson
Authors: Steven B. Karch
Journal: JAMA (1995)

<h3>To the Editor.</h3> —Last fall, a jury in Bakersfield, Calif, convicted a woman of killing her 2-month-old infant.<sup>1</sup>According to the prosecution, she had administered a lethal quantity of methamphetamine by breast-feeding. Two forensic pathologists testified for the state. They said that the death was a homicide, that the baby died of "cardiopulmonary failure due to a patent foramen ovale," and other significant findings included "methamphetamine toxicity." The foramen ovale was less than 4 mm (probe patent), and the postmortem methamphetamine level in heart blood was 39 ng/mL, comparable with levels seen in narcolepsy therapy.<sup>2</sup>Generally, amphetamine-related deaths are associated with blood concentrations of 300 to 40 000 ng/mL. Probe patent foramen ovale is a normal variant at this age, and past studies have failed to demonstrate abnormalities in the children of women who were prescribed amphetamine during their pregnancies or breast-feeding.<sup>2</sup> Although the case has received
J Thoracic &amp;amp; Cardiovascular Surgery, St. Louis
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hepatology Highlights
Authors: Alyson Kaplan, Russell Rosenblatt, Adam Buckholz, Sonal Kumar, Gopanandan Parthasarathy, Robert E. Schwartz, Petra Hirsova, Robert E. Schwartz, Joseph F. Pisa, Robert S. Brown, Nidhi Jalan‐Sakrikar, Robert E. Schwartz, Arun B. Jesudian, Nicholas W. Russo, Chaitanya Allamneni, Ravi S. Vora, Enis Kostallari, Robert E. Schwartz
Journal: Hepatology (2020)

Kaplan, Alyson; Rosenblatt, Russell; Buckholz, Adam; Kumar, Sonal; Parthasarathy, Gopanandan; Schwartz, Robert E.; Hirsova, Petra; Schwartz, Robert E.; Pisa, Joseph F.; Brown, Robert S. Jr.; Jalan‐Sakrikar, Nidhi; Schwartz, Robert E.; Jesudian, Arun B.; Russo, Nicholas W.; Allamneni, Chaitanya; Vora, Ravi S.; Kostallari, Enis; Schwartz, Robert E. Author Information