tbuckley/cabot-search huggingface dataset:
Treatment of Breast Cancer With High-Energy Electrons Produced by 24-Mev Betatron
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PRECEDENT: A randomized phase II trial comparing EC145 and pegylated liposomal doxorubicin (PLD) in combination, versus PLD alone, in subjects with platinum-resistant ovarian cancer.
Authors: R. W. Naumann, R. L. Coleman, R. A. Burger, T. J. Herzog, R. Morris, E. A. Sausville, E. Kutarska, S. A. Ghamande, N. Y. Gabrail, S. De Pasquale, E. Nowara, L. Gilbert, J. R. Caton, R. H. Gersh, M. G. Teneriello, W. A. Harb, P. Konstantinopoulos, J. T. Symanowski, C. Lovejoy, R. A. Messmann
Journal: Journal of Clinical Oncology (2011)

5045
Dose-Response Analysis in Risk Assessment: Evaluation of Behavioral Specificity
Authors: John R. Glowa
Journal: Environmental Health Perspectives (1996)

Several methods of quantitative risk assessment that have been described recently are particularly applicable to neurotoxic end points.These methods can be broadly divided into two types of approaches based on their treatment of dose-response data to estimate risks.Benchmark approaches estimate risks using variability in response to a fixed dose level in comparison with background control variability.Probabilistic approaches estimate risks using the variability in the dose to produce a small effect in the sample population.The current report seeks to extend the development of probabilistic approaches for neurotoxic end points.Because behavioral data are often used to assess therapeutic efficacy as well as toxicity (unwanted effects), this analysis focused on the relative risks of producing these effects with the same agent.The therapeutic potential of GBR 12909 was determined by its ability to decrease cocaine-maintained responding in monkeys.The effects of this agent were also assessed in the same monkeys using food-maintained responding to provide an indication of behavioral toxicity.GBR 12909 decreased both behaviors, with complete decreases on drug-seeking behavior occurring at doses that had minimal effects on food-maintained responding.The difference in the estimates of doses to decrease drug-seeking and food-maintained behavior suggested that specific therapeutic effects could be obtained in the absence of unwanted side effects for a definable proportion of the population.These results also suggest that multiple behavioral end points can be useful for identifying specific effects of chemicals for the purposes of risk assessment.
Blocking MAIT cell activation accelerates liver fibrosis regression
Authors: Morgane Mabire, Hegde Pushpa, Manon Allaire, Al Sayegh Rola, JingHong Wan, Emmanuel Weiss, Richard Moreau, Hélène Gilgenkrantz, De La Grange Pierre, Sophie Lotersztajn
Journal: Journal of Hepatology (2020)
Progress in Cancer Registration
Authors: R. M. Vick
Journal: BMJ (1958)

This is a progress report showing the rapid development of a cancer records bureau.An earlier article (Vick, 1955) is used for comparison (Table I).These figures are a sufficient indication of the steadily rising number of registrations and of cases followed up year by year.TABLE I 1953 1956 Increase Total No. of cases registered .. 39,179 65,549 26,370 No. of new cases registered .. 6,588 8,867 2,279 No. of cases followed up .. 16
Influence of Surfactant Components and Exposure Geometry on the Effects of Quartz and Asbestos on Alveolar Macrophages
Authors: Jutta Schimmelpfeng, Elisabeth Drosselmeyer, Vera Hofheinz, Arnulf Seidel
Journal: Environmental Health Perspectives (1992)

Bovine (BAM) and rat (RAM) alveolar macrophages were incubated in vitro with DQ12 quartz or UICC chrysotile asbestos either alone or in the presence of dipalmitoyl lecithin (DPL). The reaction of the cells of both species to the untreated dust particles was similar qualitatively and quantitatively, with a loss of viability and release of lactate dehydrogenase and N-acetyl-beta-glucosaminidase after 20 hr of incubation. In the presence of DPL, the toxicity of quartz to BAM disappeared completely, whereas the protective influence of the phospholipid was distinctly diminished in the case of RAM. The presence of lavage fluid was less effective than that of pure DPL. There was no protective influence of DPL with asbestos either for BAM or for RAM. The effects of phagocytizable, suspended quartz particles were compared with the effects of the same type of particles fixed on a glass surface to exclude the possibility of phagocytosis. The effect of the suspended particles on the viability and release of enzymes was more pronounced than that of the fixed particles. On the other hand, superoxide anion production was stimulated to a much higher degree by the fixed quartz particles. This could be explained by the continuing contact of the outer cell membrane with the silica surfaces, whereas free particles were rapidly phagocytized. The release of lysosomal enzymes induced by fixed quartz particles was a secondary phenomenon following cell death.
Endosomal sorting of Notch receptors through COMMD9-dependent pathways modulates Notch signaling
Authors: Haiying Li, Yeon Koo, Xicheng Mao, Luis Sifuentes-Dominguez, Lindsey L. Morris, Da Jia, Naoteru Miyata, Rebecca A. Faulkner, Jan M. van Deursen, Marc Vooijs, Daniel D. Billadeau, Bart van de Sluis, Ondine Cleaver, Ezra Burstein
Journal: The Journal of Experimental Medicine (2015)
The Beat
Authors: E Dooley
Journal: Environmental Health Perspectives (2001)

Every year in the United States wildfires destroy hundreds of homes and cause millions of dollars in damage.From January through May of this year, for example, 2,702 wildfires scorched 198,228 acres in Florida amidst one of the worst droughts in a century.Although wildfires can actually be good for the environment, helping it to stay healthy and restore itself, they can have harmful human consequences, both directly and indirectly.People in close proximity to a wildfire, such as firefighters, can suffer respiratory problems and burns, and in rare instances are killed.In addition, people living near a fire's burn who are predisposed to environmental health problems such as asthma and emphysema may be affected.Perhaps more importantly for those living downwind, forest fire smoke contains many contaminants that in the long term can, depending on the length of the exposure, produce both acute and chronic effects in humans.Wildfires are characterized as brush and forest fires that commonly happen in relatively undeveloped areas.But as
Leads from the MMWR. Alcohol-related deaths--United States, 1968 to 1978
Journal: JAMA (1984)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Massachusetts Medical Society
Authors: Robert W. Buck, William Chasen, Leo Alexander, Robert Mezer, Robert Arnot, Jerome A. Whitney
Journal: New England Journal of Medicine (1967)

STATED MEETING OF THE COUNCILA stated meeting of the Council will be held in the Georgian Room, Statler Hilton Hotel, Boston, on Wednesday, February 8, 1967, at 10:00 a.m. Business: 1. Call to order at 10:00 A.M.2. Presentation of record of meeting held October 19, 1966, as published in Vol. 275, Supplement No. 1, November 24, 1966, of the New England Journal of Medicine.3. Reports of Standing and special committees.4. Such other business as may legally come before this meeting.CIRCULAR OF ADVANCE INFORMATIONCopies of the Circular of Advance Information for Councilors will . . .
Contempo '91
Authors: Jody W. Zylke
Journal: JAMA (1991)

Reflecting on the events and achievements of the year past is commonplace. Most corporations publish an annual report. News organizations compile a "year in review." And<i>JAMA</i>recaps the year in medicine with its Contempo issue. Each year we ask leaders from some of the many medical specialties and related fields to cite what they believe are the most important developments in their areas. The aim is to inform physicians about advances in medicine outside their fields. Thirty-eight articles constitute this year's issue. As always, because of space limitations, not all specialties can be included. Much has happened in world events since our last Contempo issue. Germany was reunified, and a multinational coalition waged war against Saddam Hussein. Nationally, attention ranged from the effects of the recession to the President's dislike of broccoli. Political freedom, the horrors of war, want in America, the presidential palate. A year of contrasts. So
Status asthmaticus in children
Authors: W. Richards
Journal: JAMA (1968)

<h3>To the Editor:—</h3> In a recent letter to the editor, Dr. Fontana, in reference to our paper, "Status Asthmaticus in Children" (<b>201</b>:75, 1967), criticized our recommendation that "corticosteroids be promptly administered to all patients with status asthmaticus." He further implied that this position was not representative of other allergists' views. In explaining his stand, he condemned the indiscriminate use of steroids and advised reserving them for "life-saving situations." We are in total agreement with this contention! On the other hand, our experiences contrast sharply with regard to the management of status asthmaticus in children. It is now widely accepted that status asthmaticus is often a life-threatening situation whether or not the patient previously had received steroid therapy and, consequently, that steroids should be used for this critical complication of asthma.<sup>1-3</sup>In addition, because of the potential danger of adrenal insufficiency, with-holding of steroids for the treatment of status
THE HARVEY SOCIETY.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cimetidine in the treatment of acute intermittent porphyria
Authors: E. Baccino
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Rationing.
Authors: H. Bourne
Journal: BMJ (1992)

ficulties of taking into account the comparative purchasing power of currencies -outside the Organisation for Economic Cooperation and Development,4 and the countries' large "black economy."But people in most types of occupation, both manual and non-manual, seem to work in the black economy.Relative deprivation was seen not necessarily in relation to direct income distribution but in relation to privileges such as the ability to travel abroad or access to Western goods, privileges that in the West are related to income.Eastern Europe will be a testing ground for Wilkinson's hypothesis in view of the introduction of market forces, which will widen income dif- ferentials appreciably.
Untoward reactions
Authors: D. H. Keeling
Journal: Clinical Nuclear Medicine (1998)

Radiopharmaceuticals are used for both diagnostic and therapeutic purposes, though the great majority of administrations are for diagnostic investigations. However, the pattern of use is quite unlike that of normal drug therapy. They are not given in courses over a considerable time period, and are frequently administered only once to an individual patient. Further, they are also given in minute chemical quantities, and no pharmacological effect is intended; indeed, most are designed simply to act as tracers and not to perturb the normal or pathological processes of the body which they are tracing. Thus, it is not surprising that adverse effects attributed to them are very infrequent, particularly when compared with normal therapeutic drugs or even the newer non-ionic radiological contrast agents.
Obituary Listing
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Predictive value of diminutive colonic adenoma trial: The PREDICT trial
Authors: Philip Schoenfeld, Javaid Shad, Eric Ormseth, Walter Coyle, Brooks Cash, James Butler, William Schindler, Walter J Kikendall, Christopher Furlong, Leslie H Sobin, Christine M Hobbs, David Cruess, Douglas Rex
Journal: Clinical Gastroenterology and Hepatology (2003)
A New Test for Recurrent Colon Cancer
Journal: Annals of Internal Medicine (1999)

Summaries for Patients7 December 1999A New Test for Recurrent Colon CancerAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-131-11-199912070-00024 SectionsAboutFull Text ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?In less advanced stages (stages I and II), cancer of the colon (large intestine) does not extend outside of the large intestine, and cancer cells are not seen under the microscope in the lymph nodes that lie near the large intestine. Surgery alone is used to treat these early stage cancers; chemotherapy is reserved for cancers at more advanced stages. Despite the fact that cancer cells cannot be found with ordinary testing of the lymph nodes in early stage colon cancers, the cancer recurs after initial surgery in ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled "Guanylyl Cyclase C Messenger RNA Is a Biomarker for Recurrent Stage II Colorectal Cancer." It is in the 7 December 1999 issue of Annals of Internal Medicine (volume 131, pages 805-812). The authors are B. Cagir, A. Gelmann, J. Park, T. Fava, A. Tankelevitch, E.W. Bittner, E.J. Weaver, J.P. Palazzo, D. Weinberg, R.D. Fry, and S.A. Waldman.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoGuanylyl Cyclase C Messenger RNA Is a Biomarker for Recurrent Stage II Colorectal Cancer Burt Cagir , Alyssa Gelmann , Jason Park , Tracy Fava , Alexander Tankelevitch , Edwin W. Bittner , Eric J. Weaver , Juan P. Palazzo , David Weinberg , Robert D. Fry , and Scott A. Waldman Metrics 7 December 1999Volume 131, Issue 11Page: 805KeywordsCancer chemotherapyCancer preventionCancer treatmentCellsColorectal cancerLarge intestineLymph nodesMessenger RNAResearch laboratoriesSurgery ePublished: 15 August 2000 Issue Published: 7 December 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.Loading ...
First Payment
Authors: John Arun Mukand
Journal: JAMA (1985)

In the waiting room, she releases her white hair from a blue gauze scarf. Her body has accepted the disease with no cure, her questions are dried snail shells. The pain stays, with the appetite of crabgrass. She cannot reach inside, pluck it out by the roots. Some days, she wants to be only a gust of winter wind sweeping the fresh snow into drifts &amp; whorls on the prairie, filtering through an apple orchard. She might linger, wrap herself around naked branches, wait for spring buds. She might even learn to be patient for the orange sun to drag the bleached skeleton of each day behind the snow-tinted hills. The intercom calls. Clenching her body, she lifts herself up with a gnarled, polished walking stick. In the examining room, her eyes wander over the fresh table, the chrome lamp with its fixed gaze. The student knocks and enters, ready
Biologic Concomitants of Alcoholism
Authors: Jack H. Mendelson
Journal: New England Journal of Medicine (1970)

DependenceThe occurrence of withdrawal signs and symptoms upon cessation of drinking is evidence of physiologic dependence. Dependence is the second major pharmacologic criterion of alcohol addiction. At one time it was thought that the withdrawal syndrome reflected intercurrent illness or vitamin and nutritional deficiency rather than the effects of cessation of drinking. This interpretation of withdrawal phenomena was challenged by the clinical observations of Victor and Adams94 and the studies of Isbell et al.13 Subsequently, it was demonstrated experimentally that withdrawal signs and symptoms occur in alcoholics as a function of cessation of drinking and cannot be accounted for . . .
Can healthy people benefit from health apps?
Journal: BMJ (2015)

Furthermore, the sentence that reference 2 supports notes that the app Lose It "works just as well as or even better than paper based or website based weight loss plans."In fact, the study on Lose It compared the app against a paper based method and the memo feature on a smartphone (not a website).Finally, the lists of "deserving" and "undeserving" illnesses are the wrong way round in the penultimate paragraph.
Bitter Truth
Authors: Joan Stephenson
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal