tbuckley/cabot-search huggingface dataset:
Abstract B05: The RNA-binding protein HuR enhances exosome secretion in colorectal cancer
Authors: Ranjan Preet, Wei-Ting Hung, Shufei Zhuang, Lane K. Christenson, Dan A. Dixon
Journal: Cancer Research (2017)

Abstract Enhanced secretion of exosomes by cancer cells is recognized as a means of transferring oncogenic information within the tumor microenvironment. Through their ability to carry specific RNA and protein cargo, tumor-derived exosomes are now being recognized for their ability to impact the tumor microenvironment and as promising cancer biomarkers. However, our knowledge of the cellular factors that promote increased exosome production from tumor cells and how they impact the loading of specific tumor-promoting RNA cargo is limited. Our prior work has established that colorectal cancer (CRC) cells and tumors overexpress the key RNA-binding protein HuR (ELAVL1) early in GI tumor development. When overexpressed and present in the cytoplasm, HuR can promote mRNA stabilization of tumor-promoting genes through binding of 3'UTR AU-rich elements (ARE). These same mRNAs are within tumor-derived exosomes, suggesting a role for HuR. To test this, Tet-regulated HuR-inducible HeLa cells were used to demonstrate that cytoplasmic HuR overexpression promoted a 4-fold increase in exosome production. Furthermore, HuR was detected in exosomes produced only from HuR-overexpressing cells. The presence of HuR in exosomes directly impacted mRNA cargo, as selective uptake of ARE-containing mRNAs were observed in exosomes derived from HuR overexpressing cells. To assess if these effects were seen in CRC cells that endogenously overexpress HuR, exosome levels from CRC cells were compared to normal human intestinal epithelial and myofibroblast cells. CRC cells secrete ~3-fold greater exosome levels than normal cells and enhanced exosome production was dependent upon HuR. siRNA knockdown and CRISPER/Cas9 knockout of HuR in CRC cells showed a &amp;gt;2-fold decrease in secreted exosomes, similar to the levels observed in normal cells. Furthermore, HuR knockout CRC cells showed a ~3-fold reduction in xenograft tumor growth compared to parental CRC cells. These findings were reflected in vivo where GI-tumor bearing APCMin/+ mice produced ~3-fold more serum exosomes, with HuR as exosomal cargo in APCMin/+ mice, whereas limited expression of exosomal HuR was detected in wild-type mice. This work has identified a novel connection between HuR-mediated post-transcriptional regulation and tumor-derived exosome production, along with providing the first preclinical evidence indicating the presence of exosomal HuR as a serum-based CRC biomarker. Citation Format: Ranjan Preet, Wei-Ting Hung, Shufei Zhuang, Lane K. Christenson, Dan A. Dixon. The RNA-binding protein HuR enhances exosome secretion in colorectal cancer. [abstract]. In: Proceedings of the AACR Special Conference on Colorectal Cancer: From Initiation to Outcomes; 2016 Sep 17-20; Tampa, FL. Philadelphia (PA): AACR; Cancer Res 2017;77(3 Suppl):Abstract nr B05.
Beethoven's deafness
Authors: K. M. Stevens
Journal: JAMA (1970)

Beethoven's deafness began in his left ear at the age of 27 years but soon became a bilateral loss of high-frequency hearing associated with severe tinnitus, recruitment, and poor discrimination. He used ear trumpets and a wooden stick applied to his teeth to aid his hearing. He never had vertigo or purulent otitis. The three periods of Beethoven's composition correspond closely to stages in the progression of his deafness. This interesting correlation has led the authors to speculate on the effect his deafness might have had on the style of his musical composition. Of the possible diagnoses, including syphilis, typhoid fever, and vascular insufficiency, only cochlear otosclerosis as a single otological disease can explain all the clinical symptoms and pathological findings.
Nasal ventilation in COPD exacerbations: early and late results of a prospective, controlled study
Authors: G. Bardi, R. Pierotello, M. Desideri, L. Valdisserri, M. Bottai, A. Palla
Journal: European Respiratory Journal (2000)

Noninvasive positive pressure mechanical ventilation (NIPPV) in exacerbated chronic obstructive pulmonary disease (COPD) has been investigated early and after 1 yr of follow-up. To this end, 30 patients were enrolled in a prospective, controlled trial: 15 had early administration of NIPPV (Group A), 15 had medical therapy only (Group B); assignment was made on the basis of equipment availability only. In-hospital mortality, need for endotracheal intubation and mean length of hospitalization were lower in Group A, though the difference was not statistically significant. Arterial oxygen tension in arterial blood (Pa,O2), carbon dioxide tension in arterial blood (Pa,CO2) and HCO3- improved significantly in both groups from admission to discharge: 45.8+/-8.6 versus 64.9+/-10.0; 59.4+/-11.8 versus 48.6+/-7.3; 34.3+/-4.3 versus 30.1+/-3.4 in group A; 49.2+/-11.4 versus 60.9+/-8.2; 52.6+/-15.9 versus 44.4+/-8.7; 31.7+/-5.9 versus 28.0+/-3.6 in group B, respectively, p&lt;0.05 for all comparisons; pH, percentage forced expiratory volume in one second (FEV1) and tidal volume (VT) improved significantly in patients of group A only: 7.36+/-0.04 versus 7.41+/-0.02; 39.8+/-13.6 versus 49.4+/-11.7; 0.71+/-0.3 versus 0.84+/-0.4, respectively, p&lt;0.05. During follow-up, 3, 6, and 12 months survival rates were significantly higher in Group A than in Group B (p&lt;0.02). Hospital new admissions over 1 yr were more frequent in Group B (n=6, incidence rate: 0.216%) than in Group A (n=4, incidence rate: 0.084%). Therefore, noninvasive positive pressure mechanical ventilation may be added to "conventional" medical therapy in exacerbated chronic obstructive pulmonary disease.
Results of a Phase 1 Trial of Gda-201, Nicotinamide-Expanded Allogeneic Natural Killer Cells (NAM-NK) in Patients with Refractory Non-Hodgkin Lymphoma (NHL) and Multiple Myeloma (MM)
Authors: Veronika Bachanova, David H. McKenna, Xianghua Luo, Todd E. DeFor, Fiona He, Murali Janakiram, Erica D. Warlick, Rose Wangen, Zuzan Cayci, Bartosz Grzywacz, Guy Brachya, Tony Peled, Jeffrey S. Miller
Journal: Blood (2019)
Highly Invasive New Bacterium Isolated From US East Coast Waters
Journal: JAMA (1984)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mitogen-activated protein kinase activation in hepatocyte growth factor-stimulated rat hepatocytes: Involvement of protein tyrosine kinase and protein kinase C
Authors: T Adachi
Journal: Hepatology (1996)

Hepatocyte growth factor (HGF) stimulated mitogen-activated protein (MAP) kinases and MAP kinase kinase in primary cultured rat hepatocytes. Inhibitors for protein kinase C (PKC), Ro31-8425, H-7, and calphostin C, reduced HGF-induced MAP kinase activity. A PKC activator, phorbol myristate acetate (PMA), induced MAP kinase activation in a concentration-dependent manner. Protein tyrosine kinase (PTK) inhibitors, genistein, and ST638 also inhibited HGF-induced MAP kinase activation. Furthermore, HGF increased formation of Ras guanosine triphosphate (GTP) complex, indicating Ras activation. Genistein inhibited HGF-induced Ras activation, but Ro31-8425 was without effect. On the other hand, Ro31-8425 decreased HGF-induced [3H]arachidonic acid (AA) release and [3H]thymidine incorporation. Genistein also prevented [3H]AA release and [3H]-thymidine incorporation. Moreover, a commonly used phospholipase A2 (PLA2) inhibitor, quinacrine, decreased HGF- induced [3H]AA release and [3H]thymidine incorporation. The inhibitory profile of [3H]AA release was well correlated with that of [3H]thymidine incorporation in Ro31-8425-, genistein-, and quinacrine- treated cells. A cyclooxygenase inhibitor, indomethacin, which suppressed HGF-induced DNA synthesis, had minimal effect on MAP kinase activation. In contrast, prostaglandin (PG) E1, E2, or F2α, which stimulate [3H]thymidine incorporation to the same level as that caused by HGF in hepatocytes, caused very weak activation of MAP kinases. These results suggest that PTK, Ras, and PKC play roles in MAP kinase activation induced by HGF and that MAP kinase activation resulting in AA release is involved in DNA synthesis in rat hepatocytes.
THE PRACTICE OF MEDICINE.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Appointments Announced By M.D.Anderson Cancer Center
Journal: JNCI Journal of the National Cancer Institute (1988)

Journal Article Appointments Announced By M.D.Anderson Cancer Center Get access JNCI: Journal of the National Cancer Institute, Volume 80, Issue 10, 20 July 1988, Page 719, https://doi.org/10.1093/jnci/80.10.719-a Published: 20 July 1988
Consequences of the AF-2 Incident in Japan
Authors: Y. Tazima
Journal: Environmental Health Perspectives (1979)

The discovery of the potent mutagenicity of AF-2, which was once used in Japan as a food preservative, has exerted a great influence not only on screening procedures for carcinogenic compounds but also on legislative approaches to mutagenic substances. It promoted the synthesis of exceedingly sensitive and reliable tester strains in Salmonella and supported the hypothesis of a common mechanism between mutagenicity and carcinogenicity. Thus preliminary screening for carcinogenic substances has become feasible using mutagenicity as an index. It also contributed greatly to the formulation of legislative measures for chemical substances which for the first time gave due attention to mutagenicity. Furthermore, the exposure of a large population to such a potent mutagen raised a question as to what extent the genetic constitution of the Japanese population might have been damaged. This suggested that urgent need for a system to monitor the total genetic damage to a human genome.
Prospective payment for physician services. Impact on medical consultation practices
Authors: S. R. Lowenstein
Journal: JAMA (1985)

IN THE near future Congress is expected to begin formal consideration of "physician diagnosis-related groups" (DRGs). The debate will undoubtedly prove contentious and controversial, as policymakers, physicians, and economists confront a number of important questions: Will extending DRGs to cover physician payments actually save money? Will DRGs provide fair and equitable reimbursement for physicians? Will physicians circumvent the system by pursuing the counterproductive incentives inherent in the DRGs? What will happen to quality of patient care and access to services? This last question is particularly vexing; how will quality and accessibility of care be preserved, even as physicians may receive less for their work and perform fewer services for patients? This article examines the potential impact of a physician DRG system on one important clinical activity that has often been equated with good quality medical care—the referral of patients for consultations. <h3>Background</h3> Efforts to curb the alarming escalation of Medicare
Abstract 2955: Development of non-apoptotic, caspase-independent cell death inducers against cancer cells
Authors: Mariah A. Pasternak, Noor Hussein, Karthikeyan Chandrabose, Paul W. Erhardt, Amit K. Tiwari
Journal: Cancer Research (2019)

Abstract Since most cancer therapeutics currently exert their effects using apoptotic pathways to which cancer cells can become resistant, it is important to develop new drug molecules that work through non-apoptotic pathways. A novel, non-apoptotic cell death mechanism called “methuophagy,” which combines features of both autophagy and methuosis, is being examined using structure-activity relationship (SAR) studies of synthesized compounds. Methuosis is a non-apoptotic cell death that includes macropinocytosis and the fusing of smaller vesicles into larger vesicles that is seen along with cell death. BAPT compounds that induce methuophagy have been synthesized, and minor changes on a primary scaffold are being used to determine the SAR for the series. The series retains the 4-pyridinyl moiety that induced methuosis with the compound MOMIPP. Screening experiments with HCT-116 colorectal cancer cells (CRC), BT-20 triple-negative breast cancer cells (TNBC), and U-251 glioblastoma cancer cells (GBM) have shown that compounds having a rigid, completely aromatic structure with three aromatic centers induce methuophagy more potently than compounds with a “hydrazone-like” moiety or a non-aromatic linker. The cell death caused by methuophagy can be seen as early as 6 hours, with small vacuoles that coalesce together to form larger vacuoles. From these screening experiments, it has been concluded that the completely aromatic compounds are the most promising candidates for methuophagy drug development and will be used in experiments to determine protein targets and in vivo to further determine efficacy. Citation Format: Mariah A. Pasternak, Noor Hussein, Karthikeyan Chandrabose, Paul W. Erhardt, Amit K. Tiwari. Development of non-apoptotic, caspase-independent cell death inducers against cancer cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2955.
Ibrutinib Resistance in Chronic Lymphocytic Leukemia
Authors: Gustaaf Reurink, Gert Goudswaard, Maarten Moen, Adam Weir, Jan Verhaar, M Sita, Mario Maas, Johannes Tol
Journal: New England Journal of Medicine (2014)

corrections 0.96; 95% confidence interval [CI], 0.61 to 1.51; P = 0.66) (Fig. 1).The reinjury rate was 16% in the PRP group and 14% in the placebo group (odds ratio, 1.17; 95% CI, 0.33 to 4.18; P = 0.81).There were no serious adverse events.Although the 95% confidence interval still allows for a small chance that there was a clinically relevant between-group difference, our study demonstrated no benefit for intramuscular PRP injections, as compared with placebo injections, in patients with acute hamstring injuries.
Chemotherapy Of Leprosy
Authors: R. Hastings
Journal: The Annual Review of Pharmacology and Toxicology (1988)

Heme oxygenases (HO) catabolize free heme, that is, iron (Fe) protoporphyrin (IX), into equimolar amounts of Fe2+, carbon monoxide (CO), and biliverdin. The stress-responsive HO-1 isoenzyme affords protection against programmed cell death. The mechanism ...Read More
Manuscripts Approved for JNCI, October 1 to November 1, 1967
Journal: JNCI Journal of the National Cancer Institute (1967)

Manuscripts Approved for JNCI, October 1 to November 1, 1967 Get access JNCI: Journal of the National Cancer Institute, Volume 39, Issue 6, December 1967, Page 1271, https://doi.org/10.1093/jnci/39.6.1271 Published: 01 December 1967
The Family Scrapbook
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ACTINOMYCOSIS
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prognosis of alcoholic or viral B/C cirrhosis according to ABO blood group: results of abocirralvir, from CIRRAL and ANRS CO12 CirVir cohorts
Authors: Isabelle Ollivier-Hourmand, Pierre Nahon, Cendrine Chaffaut, Thong Dao, Nga Nguyen, Marcellin Patrick, Dominique Roulot, Victor de Lédinghen, Stanislas Pol, Dominique Guyader, Isabelle Mabile-Archambeaud, Fabien Zoulim, Frédéric Oberti, Albert Tran, Jean-Pierre Bronowicki, Louis Dalteroche, Denis Ouzan, Jean Marie Peron, Jean-Pierre Zarski, Marc Bourliere, Dominique Larrey, Alexandre Louvet, Paul Cales, Armand Abergel, Philippe Mathurin, Ariane Mallat, Jean-Frédéric Blanc, Eric Nguyen Khac, Ghassan Riachi, Laurent Alric, Lawrence Serfaty, Tereza Antonini, Christophe Moreno, Pierre Attali, Dominique Thabut, Christophe Pilette, Jean Didier Grange, Christine Silvain, Nicolas Carbonell, Brigitte Bernard Chabert, Odile Goria, Claire Wartelle-Bladou, Romain Moirand, Christos Christidis, Gabriel Perlemuter, Violaine Ozenne, Jean Henrion, Sophie Hillaire, Vincent Di Martino, Xavier Amiot, Angela Sutton, Nathalie Barget, Yohann Repesse, Sylvie Chevret, Nathalie Ganne-Carrié
Journal: Journal of Hepatology (2020)
Environmental Illness
Authors: Leo Galland
Journal: JAMA (1991)

<h3>To the Editor.—</h3> Black et al<sup>1</sup>draw the wrong conclusions in reporting on psychological profiles of patients with EI. It is not surprising that individuals who have stopped working (69%) or have been hospitalized (50%) because of illness show a higher prevalence of mood, anxiety, or somatoform disorders than healthy controls. The most important statistic in their report is this: if the three psychiatric clinic patients are excluded, 40% of patients with EI showed no significant psychopathology, past or present. This finding contradicts their notion that EI is basically a psychiatric illness in disguise.<sup>2</sup> In conducting a study comparing patients with EI and patients with somatic complaints who denied sensitivity to environmental chemicals,<sup>3</sup>I had to discard 68% of potential control patients because a thorough history revealed that these patients experienced ill effects from ordinary exposures to solvents, automobile exhaust, and other volatile materials. Adverse reactions to
PHYSICIAN AS WITNESS TO WILL WAIVES SPECIAL PRIVILEGE.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal