tbuckley/cabot-search huggingface dataset:
Scarlet Fever
Authors: Conrad Wesselhoeft, Louis Weinstein
Journal: New England Journal of Medicine (1945)

EpidemiologyThere has been a marked decline in the severity of scarlet fever in the last thirty years.40 The mortality rate has dropped materially in the northern states, but this has not been apparent in the South.41 Furthermore, as pointed out by Stebbins,41 where the incidence of scarlet fever has declined there is not always a comparable reduction in the incidence of other streptococcic infections. This statement applies more to states and municipalities than to military organizations.In the last few years the newer technics of identifying beta-hemolytic streptococci have been used in several studies of the epidemiology of scarlet . . .
Nuclear medicine
Authors: M. L. Nusynowitz
Journal: JAMA (1979)

<h3>A Quarter Century of Progress</h3> The 25th annual meeting of the Society of Nuclear Medicine in June 1978 marked an era of tremendous growth for this dynamic multidisciplinary specialty. In the silver anniversary commemorative issue of the<i>Journal of Nuclear Medicine</i>, DeLand<sup>1</sup>enumerated those nuclear medical modalities that are currently important and available to the clinician. They include procedures that represent all aspects of the field—imaging, physiological studies, in vitro procedures, and therapy. The instrumentation, radiopharmaceuticals, and techniques developed during the past quarter century have resulted in procedures such as skeletal, hepatic, and brain imaging for the diagnosis of cancer; pulmonary ventilation and perfusion scintigraphy for the evaluation of pulmonary embolism; and thyroid function testing, imaging, and hormone radioassay, indispensable in the management of thyroid disease. <h3>Noninvasive Diagnostic Methods</h3> The momentum of the past has been sustained in more recent years as well. The marriage of the digital computer to
Clinical range of neonatal rotavirus gastroenteritis.
Journal: BMJ (1983)

contacts, however, yielded 12 patients with the disease, of whom eight were children, which underlines the efficiency of the service if properly applied.The public reaction to the articles in local papers was interesting, and evidently there are still many misconceptions about tuberculosis.Most of the people who submitted themselves for x ray examination were totally ignorant of the implications of the disease and reacted in a way more reminiscent of the plague or smallpox.This shows again how powerful an influence the media may be in medical matters.The unjustified loss of trade to the public house must also be a matter of some concern and reflects to some extent the public attitude to the disease.In conclusion, this epidemic serves to emphasise two long established but probably forgotten truths about tuberculosis.Firstly, tuberculosis still exists in this country and is not merely a disease of immigrants, social outcasts, and alcoholics; in non-vaccinated people it remains a highly contagious disease of young adulthood.The BCG vaccination, however, is safe, free from systemic side effects, and of proved efficacy when given at the age of maximum susceptibility to the disease.Every effort should be made to pursue the schools vaccination programme, particularly in children who initially default.Secondly, the public should be made aware that tuberculosis in all forms can be cured completely with drugs at little personal inconvenience.We thank the Bradford chest physicians for access to their patients. References
The Legacy
Authors: John C. Cozart
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Paroxysmal nocturnal hemoglobinuria with renal failure
Authors: H. Rubin
Journal: JAMA (1971)

A patient with paroxysmal nocturnal hemoglobinuria (PNH) associated with acute renal failure survived the episode of acute renal failure with return of renal function towards normal. Postmortem examination failed to reveal evidence of significant underlying renal disease. Acute renal failure following intense hemoglobinuria in PNH can occur in the absence of underlying renal disease. When chronic renal failure supervenes in patients with chronic hemoglobinuria, renal disease, presumably unrelated to the hemoglobinuria, is an almost uniform finding.
Constantin von Monakow (1853-1930), neurobiologic philosopher
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Estrogen Receptor Polymorphisms Associated With Enhanced Response of HDL to Estrogen Replacement Therapy in Postmenopausal Women
Authors: David M. Herrington, Timothy Howard, Allison Florance, Jianfeng Xu, Eugene R. Bleecker, Deborah A. Meyers
Journal: Circulation (2001)

P14 HDL levels in women are highly heritable and also modulated by endogenous and exogenous estrogen. Several estrogen receptor polymorphisms (ERPs) exist, however, their influence on estrogen’s effects on HDL are unknown. To determine if ERPs modify the HDL response to estrogen replacement, we studied ERP genotypes and pre/post HDL levels in 274 unrelated women (mean age 65 years, 82% white)in the Estrogen Replacement and Atherosclerosis (ERA) trial. Associations between alleles of two single nucleotide polymorphisms(XbaI and PvuII) and follow-up HDL levels were examined after adjustment for baseline levels of HDL and age, diabetes, BMI, exercise, and alcohol intake. Results. See table. Both PvuII and XbaI are in H-W equilibrium. XbaI is only 50 base pairs from PvuII, is in strong linkage disequilibrium with XbaI (p&lt;0.0000), and shows a similar association with changes in HDL levels. Conclusion. This association study suggests a drug-gene interaction between estrogen and ERPs with respect to HDL levels. Confirmation in other populations and functional genomic studies are needed to fully determine the functional and clinical significance of these polymorphisms. Table 1.
Toll-like receptor 4 inhibition acts synergistically with G-CSF to prevent organ injury and induce liver regeneration in acute-on-chronic liver failure
Authors: Cornelius Engelmann, Fausto Andreola, Abeba Habtesion, Simone Novelli, Annarein Kerbert, Nathan Davies, Sofia Ferreira-Gonzalez, Stuart Forbes, Thomas Berg, Rajiv Jalan
Journal: Journal of Hepatology (2020)
Public Health Reports, Washington
Journal: JAMA (1966)

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THE PREVENTION OF NEPHRITIS AS A COMPLICATION OF SCARLET FEVER.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Right Temporal Lobe Damage: Perception of Unfamiliar Stimuli After Damage
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medical Writing
Authors: David Hendin
Journal: JAMA (1974)

<h3>To the Editor.—</h3> Bravo to your reply to Lois DeBakey's letter (227:440, 1974). She insinuates that "authenticity, literacy, scholarship" are not compatible with readability. Indeed, as you point out, they are tantamount. I daresay that if more of what DeBakey calls "lay journalists" (I prefer "professional science or medical journalist") aided more doctors who author research reports, the results would be gratifying. Doctors don't ask me to doctor. Likewise, neither I nor my colleagues ask doctors to write our (newspaper) columns. It is a rare case when an individual can do both well. Thus, it seems that the synergism obtainable by a working together of both professions would, most of all, aid the physicians who read the journals. Even most doctors I have known admit to difficulty in slushing through the "medical-ese" in most respected journals. Up with cooperation and down with elitism.
Programs in Medical Education Sponsored by Government Agencies
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Family medicine. An emergent specialty
Authors: J. A. Sergent
Journal: JAMA (1967)

To adequately speak of family practice we should have some idea of what we are speaking about. Family practice apparently means different things to different people. Some of the discrepancies are understandable in terms of the parts of the country in which the definition arises. A physician, for example, who does family practice in a small town in South Dakota may be doing something very different from a physician who practices the same specialty in Rochester, NY. Nevertheless, until we decide on a definition that is reasonably uniform, we will not be able to establish the identity of this area of medical practice, and will, therefore, lose one of the largest potential magnets to draw students to it. Before defining what I think family practice<i>is</i>, I would describe some of the things it is<i>not</i>. <h3>Family Practice Is Not</h3> It is certainly not general practice. In urban areas now,
Effect of Co-Morbidities on Anticoagulation Rates Among Chronic Atrial Fibrillation Patients
Authors: Maria T Hernandez, Carolyn V Harper, Rita F Redberg
Journal: Circulation (2001)

P50 Background: Anticoagulation (AC) with warfarin among patients with chronic atrial fibrillation (AF) continues to be underutilized despite proven effectiveness in stroke prevention and mortality reduction. The increased benefits of AC among patients with specific co-morbidities is also well established. However, concerns about negative health outcomes may be a barrier to AC in patients with co-morbidities. This study examines the effect of co-morbidities on AC rates. Methods: A random sample of 2,450 California Medicare fee-for-service inpatient records with a discharge date in 1998 and a diagnosis of AF was selected. We analyzed rates of co-morbidities associated with an increased risk for stroke among chronic AF patients (congestive heart failure (CHF), angina pectoris, myocardial infarction, diabetes, hypertension, and prior stroke/TIA). AC rates were analyzed by chi-square and multivariate logistic regression. Results: Data was available for 2369 records (96.7%). Cases were excluded for contraindications to AC (n=731), non-chronic AF (n=717), death (n=200) and age &lt; 65 years (n=24). After exclusions, there were 697 (29.4%) cases for analysis. The majority of patients with chronic AF (56.8%, 396/697) were not prescribed warfarin at discharge. Crude rates of co-morbidities were: hypertension 70%, angina pectoris 63%, CHF 47%, myocardial infarction 37%, prior stroke/TIA 27%, diabetes 25%. Almost all patients (94%) had at least one co-morbidity. Multivariate analysis controlling for age, gender, and all co-morbidities identified prior stroke/TIA (OR 2.1, p&lt;.01) and CHF (OR 1.9, p&lt;.01) to be associated with increased AC rate. Conclusion: Although it is encouraging that AC rates were higher in high risk groups with prior stroke/TIA and CHF, prescription rates were still only about 50%, indicating many missed opportunities for stroke prevention. The markedly high prevalence of all co-morbidities in a randomized sample highlights the importance of continued education emphasizing the increased benefits of AC in patients with co-morbidities.
Gastro-Intestinal Diseases. Lectures Delivered at the James Mackenzie Institute for Clinical Research, St. Andrews Winter Session, 1927.
Journal: JAMA (1929)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Complementary medicine: time for critical engagement
Authors: None The Lancet
Journal: The Lancet (2000)

Ulrich Tröhler, professor of the History of Medicine at the University of Freiburg, Germany, has recently published a controversial analysis of the way in which numerical evidence came to underpin modern therapeutics (To Improve the Evidence of Medicine, Royal College of Physicians of Edinburgh, 2000). His work is over 20 years old, but it remains important in today's debate about the acceptability of new and sometimes unorthodox medicines. Tröhler shows how "arithmetic observationists and experimentalists" in the 18th century laid the early foundations for conducting clinical trials.
P2.01-24 CANOPY-2: Phase 3 Study of Canakinumab Plus Docetaxel as Second/Third Line Therapy in Locally Advanced/Metastatic NSCLC
Authors: L. Paz-Ares, Y. Goto, D. Lim, V. Papadimitrakopoulou, B. Mookerjee, I. Malet, Z. Zewen, M. Reck
Journal: Journal of Thoracic Oncology (2019)
THE VALUE OF MEDICAL BIOGRAPHY TO THE MEDICAL STUDENT.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Don't panic
Authors: C. Richmond
Journal: BMJ (1994)

Age-related memory impairment (AMI) is a critical and debilitating phenotype of brain aging, but its underlying molecular mechanisms are largely unknown. In <i>Drosophila</i>, AMI is highly correlated with PKA activity in the mushroom bodies, neural centers essential for forming associative olfactory memories. Heterozygous mutations in <i>DC0</i> (<i>DC0</i>/+), which encodes the major catalytic subunit of PKA (PKAc), significantly suppress AMI, while overexpression of a <i>DC0</i> transgene (<i>DC0</i><sup>+</sup>) impairs memory and occludes AMI. PKA activity does not increase upon aging, and it is not clear whether AMI is caused by continual PKA activity throughout aging or by an acute increase in PKA signaling at old ages. Likewise, it is not clear whether AMI can be ameliorated by acute interventions at old ages or whether continuous intervention throughout aging is necessary. We show here that an acute increase in PKA activity at old ages is sufficient to restore normal AMI in <i>DC0</i>/+ flies. Conversely, acute expression of a PKA inhibitory peptide at old ages is sufficient to reverse AMI in a wild-type background. These results indicate that AMI in <i>Drosophila</i> is caused by an age-dependent change in PKA-dependent signaling that can be reversed by acute interventions at old ages.
Smallpox virus destruction delayed yet again
Authors: C. Marwick
Journal: JAMA (1995)

THE PERILS of Pauline are nothing to the vicissitudes that are befalling variola. The 15-year-long maneuvering involved in getting everyone to agree to destroy the remaining stocks of the world's smallpox virus—stored in the United States and in Russia—has run into yet another hitch. The virus' destruction was originally scheduled by the World Health Organization (WHO) for December 1993, after its molecular structure had been sequenced. Destruction was delayed because some scientists believed that keeping the live virus offered opportunities for further research, and the date was set for June 1995 (<i>JAMA</i>. 1993;270:2908). Now the final date has been delayed again. The executive board of the WHO, sensing a difference of opinion among the delegates on the committee charged with deciding the virus' fate, has recommended that a vote for decision not be brought to the WHO general assembly until a greater consensus is obtained, according to a US government