tbuckley/cabot-search huggingface dataset:
Penicillamine nephropathy.
Authors: D R Swinson, E E Hamilton, F E Dische
Journal: Annals of the Rheumatic Diseases (1975)

<h3>Abstract</h3> <h3>Background</h3> Standard BOLD connectivity analyses depend on aggregating the signals of individual voxels within regions of interest (ROIs). In certain cases, this spatial aggregation implies a loss of valuable functional and anatomical information about subsets of voxels that drive the ROI level connectivity. <h3>New Method</h3> We use the FGES algorithm, a data-driven score-based graphical search method, to identify subsets of voxels that are chiefly responsible for exchanging signals between ROIs. We apply the method to high-resolution resting state functional magnetic resonance imaging (rs-fMRI) data from medial temporal lobe regions of interest of a single healthy individual measured repeated times over a year and a half. <h3>Results</h3> The FGES algorithm recovered subsets of voxels within larger medial temporal lobe ROIs of entorhinal cortex and hippocampus subfields that show spatially consistency across different scanning sessions, and are statistically significant under tests that validate the role of these subsets as main drivers of effective connectivity between hippocampal regions of interest. <h3>Comparison with Existing Methods</h3> In contrast to standard functional connectivity methods, the FGES algorithm is robust against false positive connections produced by transitive closures of adjacencies (correlation methods) and common effect conditioning (Markov random field methods). <h3>Conclusions</h3> The FGES algorithm allows for identification of communication subsets of voxels driving the connectivity between regions of interest, recovering valuable anatomical and functional information that is lost when ROIs are aggregated. The FGES algorithm is specially suited for voxelwise connectivity research, given its short running time and scalability to big data problems.
Influence of the Common Human d-Aminolevulinate Dehydratase Polymorphism on Lead Body Burden
Authors: James G. Wetmur
Journal: Environmental Health Perspectives (1994)

&Aminolevulinate dehydratase (ALAD) is the second enzyme in the heme biosynthesis pathway.ALAD is a zinc metalloenzyme, and its inhibition by lead substitution for zinc is one of the most sensitive indicators of blood-lead accumulation, a measure of recent lead exposure.Stoichiometry calcu- lations indicate that a significant portion of blood lead is stored in ALAD.Human ALAD exhibits a charge polymorphism, with about 20% of Caucasians expressing the rarer ALAD2 allele.Human ALAD1 and ALAD2 cDNAs and the 16-kb ALAD gene have been cloned and sequenced.A simple polymerase chain reaction test has been established and validated for determining ALAD genotypes.Two population studies have indicated that lead-exposed individuals with the ALAD allele have blood-lead levels about 10 pg/dl greater than similarly exposed individuals carrying only the ALAD1 allele.Ongoing work is directed toward determining the biochemistry underlying the allele-specific accumulation of blood lead, and toward determining the contribution of human ALAD genotype to lead accumulation in other tissues in transgenic mouse models and to final lead deposi- tion in bone in both mouse and man.-
Induced Differentiation of Erythroleukemia Cells by Hexamethylene Bisacetamide: A Model for Cytodifferentiation of Transformed Cells
Authors: Paul A. Marks, Richard A. Rifkind
Journal: Environmental Health Perspectives (1989)

There is considerable evidence that malignant transformation need not eliminate the potential for a cell to express its developmental capabilities. This review explores the process whereby polar compounds, hexamethylene bisacetamide (HMBA) in particular, induce murine erythroid leukemoid cells (MELC) to express the differentiated erythroid phenotype, including hemoglobin production and cessation of cell division. This is a multi-step process which, although the mechanisms of action of HMBA are not yet fully understood, is amenable to experimental definition and analysis. Early effects, including changes in protein kinase C activity, in ion transport, and in expression of certain nuclear proto-oncogenes, have been examined in relation to the onset of terminal cell differentiation. This experimental experience has formed the context for initiating preliminary clinical studies designed to examine the pharmacology of HMBA and to explore its potential for modifying the natural history of cancer.
Corrigenda
Journal: BMJ (1938)

profits to the date of death, and should be supplied.From August 12 to November 1 the executors are liable in respect of the profits of that period-if the income tax authorities are willing to accept the amount of the cash receipts as the amount of the gross income of that period that is obviously convenient, but they can insist on the value of the gross bookings being taken if they desire, and that course is the one which is legally correct.From November 1 onwards " H. C. M." is personally liable, and
College Commencements.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
NEWS ITEMS.
Journal: JAMA (1883)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bortezomib ± irinotecan in relapsed/refractory colorectal cancer (CRC): Interim analysis results from phase (ph) 2b study
Authors: T. Dragovich, H. J. Lenz, C. M. S. Rocha Lima, P. Kozuch, H. Hochster, B. O'Neil, O. Atiq, J. M. Pipas, O. Kashala, D. P. Schenkein
Journal: Journal of Clinical Oncology (2004)

3591
Crohn Disease
Authors: Richard S Blumberg
Journal: JAMA (2008)

This article describes, in clinical and pathologic detail, a disease of the terminal ileum characterized by a subacute or chronic necrotizing and cicatrizing inflammation. The ulceration is reported to be accompanied by a disproportionate connective tissue reaction of the involved intestinal wall, which frequently leads to stenosis of the lumen and is associated with the formation of multiple fistulas.The disease is clinically featured by symptoms resembling those of ulcerative colitis, ie, fever, diarrhea, emaciation, and a mass in the right iliac fossa usually requiring surgical resection. The etiology is unknown.See PDF for full text of the original JAMA article.
Independent Review of Industry-Generated Data
Authors: Devra L. Davis, A. Karim Ahmed
Journal: Environmental Health Perspectives (1998)

Thus, despite Katsnelson's interesting model for testing arsenic for carcinogenicity and his findings of a few unusual application-site gastric tumors, we remain uncon- vinced that the collective experimental findings on arsenic can be taken as proof that arsenic is carcinogenic to animals; by this we mean, on the singular basis of the available animal data (and, for the moment, ignoring the human data), that neither IARC nor the National Toxicology Program (NTP) would judge arsenic as a "probable" or "reasonably anticipated" human carcinogen.The available animal data alone simply do not meet the cri- teria for either IARC or the NTP to consider the laboratory evidence as being adequate and sufficient to list arsenic as a likely carcinogen to humans.Of course, both organizations do consider arsenic and arsenic compounds as being unequivocally carcinogenic to humans based on epidemiological data.
CANCER AS A CHRONIC DISEASE
Journal: JAMA (1953)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Anesthesiology
Authors: E. M. Papper, S. H. Ngai
Journal: New England Journal of Medicine (1954)

Infant ResuscitationThe provision of a painless labor for the mother is always accompanied by the possibility of respiratory depression of the newborn infant by anesthetic agents. Obstetric complications in addition to prematurity and malformation of the newborn can interfere with normal respiratory and circulatory functions, and are responsible for many neonatal complications and deaths. The value of most methods of infant resuscitation has not been on a secure basis since gross survival rates have been the only clinical measure of success or failure. To establish objectively the condition of the newborn Apgar142 proposed a new method of clinical evaluation. . . .
Lucid
Authors: Jonathan H. Marks
Journal: JAMA (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
"Nine Years of Diphtheria."
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ectopic Thyroid Tissue and Ectopic Thyroid Carcinoma: Review of the Literature and Report of a Case
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Evaluating the Effects of Endocrine Disruptors on Endocrine Function during Development
Authors: Robert Bigsby, Robert E. Chapin, George P. Daston, Barbara J. Davis, Jack Gorski, L. Earl Gray, Kembra L. Howdeshell, R. Thomas Zoeller, Frederick S. vom Saal
Journal: Environmental Health Perspectives (1999)

The major concerns with endocrine disruptors in the environment are based mostly on effects that have been observed on the developing embryo and fetus.The focus of the present manuscript is on disruption of three hormonal systems: estrogens, androgens, and thyroid hormones.These three hormonal systems have been well characterized with regard to their roles in normal development, and their actions during development are known to be perturbed by endocrine- disrupting chemicals.During development, organs are especially sensitive to low concentrations of the sex steroids and thyroid hormones.Changes induced by exposure to these hormones during development are often irreversible, in contrast with the reversible changes induced by transient hormone exposure in the adult.Although it is known that there are differences in embryonic/ fetal/neonatal versus adult endocrine responses, minimal experimental information is available to aid in characterizing the risk of endocrine disruptors with regard to a number of issues.Issues discussed here include the hypothesis of greater sensitivity of embryos/fetuses to endocrine disruptors, irreversible consequences of exposure before maturation of homeostatic systems and during periods of genetic imprinting, and quantitative information related to the shape of the dose-response curve for specific developmental phenomena.
Gastrointestinal cancer. Treatment with fluorouracil-nitrosourea combinations
Authors: C. G. Moertel
Journal: JAMA (1976)

GASTROINTESTINAL cancer will afflict 168,000 Americans this year, and 102,000 will die.<sup>1</sup>This incidence exceeds that for any other organ system by a wide margin. Management of cases resistant to traditional curative efforts is, therefore, one of the most commonplace major disease problems encountered in American medical practice. Over the past 17 years, the only accepted tool for specific treatment of advanced gastrointestinal cancer has been fluorouracil (5-FU). This drug has been able to produce only incomplete and transient tumor shrinkage for a small minority of patients (usually in the 15% to 20% range). There is no evidence that such treatment contributes to patient survival regardless of the stage of the disease at which it is applied. Regrettably, intensive research has uncovered no other single drug that exceeds or even matches the limited accomplishments of fluorouracil for the patient with gastrointestinal cancer. Recently, therefore, increased attention has been given
What Next?
Authors: H. EDWARD HOLLING
Journal: Annals of Internal Medicine (1971)

Letters, Comments, and Corrections1 August 1971What Next?H. EDWARD HOLLING, M.D.H. EDWARD HOLLING, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-75-2-323_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: As the new Editor (formerly the Associate Editor) takes over, your readers look for clues to indicate what trends the ANNALSwill follow. What are we to make of the "gram Positive" editorial in the May issue? Was the editorial play on the wordspenogram, renogram, penohemogram, and penohemorheoradiogramwhat it seemed, a display of semasiology, or was it provoked by an upsurge of phallicism? Will the ANNALSjoin with Masters and Johnson in counteracting prudery? Does the new Editor believe with them that "the penis constantly has been viewed but rarely seen. . . . Our... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: H. EDWARD HOLLING, M.D.Affiliations: Hospital of the University of Pennsylvania Philadelphia, Pa. 19104 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1971Volume 75, Issue 2 Page: 323-323 Keywords Penis ePublished: 1 December 2008 Issue Published: 1 August 1971 PDF downloadLoading ...
Thyroid nodules after high-dose external radiotherapy. Fine-needle aspiration cytology in diagnosis and management
Authors: H. T. Pretorius
Journal: JAMA (1982)

From 1974 to 1980, we studied six patients, five treated for Hodgkin's disease and one for a hemangioma, in whom thyroid nodules developed after high-dose (2,500 to 4,000 rad) thyroid radiation. Fine-needle aspiration cytology of the thyroid in five cases showed moderate to severe cellular atypia in four (three of whom had elevated serum thyrotropin levels) and mild atypia in one (who was overtly hypothyroid). In the four with marked atypia, surgical pathology disclosed Hashimoto's thyroiditis in one, diffuse hyperplasia and epithelial atypia in two, and a sclerosing papillary carcinoma in one. Among five patients who had total thyroidectomy, three had carcinoma (microscopic papillary, papillary-follicular, or sclerosing papillary) in addition to one or more follicular adenomas or colloid nodules. Thyroid nodules and neoplasia may be more common than previously appreciated in patients exposed to high-dose radiation. (<i>JAMA</i>1982;247:3217-3220)
EDITORIAL
Journal: British Journal of Sports Medicine (1980)

This issue is devoted almost completely to the Proceedings of the Sports Injuries Symposium held at the University of Exeter in September, 1979, sponsored by the Boots Company Ltd., and organised by their agents, the Biggs Commun- ications Group Ltd., who were responsible for tape recording the conference and transcribing the tapes.These transcriptions of papers delivered verbally had to be edited, and in many cases rewritten, then checked by the authors before the usual procedures of typesetting, proof correction, incorporation of illustrations and final make-up and indexing could be done, hence the inevitible delay.Regular readers will notice some changes in the format of the journal, in expanding the information given about methods of purchasing it, and contact addresses of the officers of the British Association of Sport and Medicine, the organisation that publishes the journal.We also welcome most warmly the appointment of Surgeon Rear Admiral Stanley Miles to the newly created office of Chairman of the Editorial Board, and know that his previous experience
Long-term survival following abdominal aortic aneurysmectomy
Authors: A. G. Baker
Journal: JAMA (1970)

Long-term results of resection of unruptured abdominal aortic aneurysms confirm the value of this operation. The conditions of 240 such patients from the Hospital of the University of Pennsylvania were followed up for a minimum of three years. Since the operative mortality has been consistently falling, the early high mortality figures unrealistically lower present long-term survival. Therefore, data including and excluding operative mortality were studied. For the entire series, the five- and ten-year survivals were 54% and 22%. For the 217 operative survivors, the percentages were 61% and 25%. These results appear to show a nearly doubled life expectancy of patients subjected to operation when compared to those not operated upon.
Dose-Response Relationship in Radiogenic Breast Cancer: Reply
Authors: Irwin D. J. Bross
Journal: JNCI Journal of the National Cancer Institute (1978)

Dose-Response Relationship in Radiogenic Breast Cancer: Reply Get access Irwin D. J. Bross, Ph.D. Irwin D. J. Bross, Ph.D. Director of Biostatistics Roswell Park Memorial Institute Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 60, Issue 4, April 1978, Pages 728–729, https://doi.org/10.1093/jnci/60.4.728-a Published: 01 April 1978