tbuckley/cabot-search huggingface dataset:
Ex-AMA president Max Parrott, MD, also served
Journal: JAMA (1994)

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Effects of Intermittent Positive Pressure Breathing on Intrathoracic Pressure, Pulmonary Mechanics and Work of Breathing
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Disclaimer.
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Treatment of Alcoholism and Nicotine Dependence-Reply
Authors: Richard D. Hurt
Journal: JAMA (1996)

<h3>In Reply.</h3> —There is no doubt that improvement in functional outcome is an important measure of the effectiveness of alcoholism treatment. However, if the patient has achieved social stability and psychosocial adjustment but still dies prematurely because of an untreated addictive disorder, we believe this is a less than desirable outcome. Mortality is the ultimate outcome by which many medical treatments are judged. Many studies point out that mortality is an important outcome following alcoholism treatment.<sup>1,2</sup> The problem in most addictions treatment programs at this time is that nicotine dependence is not addressed in the same way that other addictive disorders are treated. Historically, the early efforts at treatment of alcoholism by the Salvation Army did include the treatment of nicotine dependence.<sup>3</sup>Somewhere between then and the early 1960s when inpatient treatment programs began to develop, that concept was lost and the emphasis was on treating the alcoholism to the
Health Professionals Persecuted in Violation of Their Human Rights: A Partial List of Cases
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Virtual Brain and Skull
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Heart Rate Alternans
Authors: Philip F. Binkley
Journal: Annals of Internal Medicine (1995)

Letters1 September 1995Heart Rate AlternansPhilip F. Binkley, MDPhilip F. Binkley, MDThe Ohio State University; Columbus, OH 43210-1228Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-123-5-199509010-00025 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:The authors appreciate Dr. Spodick's insight into our observations. As he notes, the truly novel aspect of this observation is the demonstration of a high-frequency band of heart rate variability whose origin differs from that of the phasic variation of vagal tone (classically described in the current literature on heart rate spectral analysis). Indeed, previous reports of frequency analysis of heart rate variability in patients with congestive heart failure have uniformly found that high-frequency variations in heart rate are markedly reduced. This was shown in our patient during periods in which pulsus alternans was not evident. Therefore, as ...References1. Spodick DH, St. Pierre JR. Pulsus alternans. Physiologic study by noninvasive techniques. Am Heart J. 1976; 80:766-77. Google Scholar2. Spodick DH, Khan AH, Pigott VM. Systolic and diastolic time intervals in pulsus alternans. Am Heart J. 1974; 87:5-10. Google Scholar3. Lewis T. Notes upon alternation of the heart. Q J Med. 1911; 4:141-4. Google Scholar Author, Article, and Disclosure InformationAuthors: Philip F. Binkley, MDAffiliations: The Ohio State University; Columbus, OH 43210-1228 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1995Volume 123, Issue 5Page: 394KeywordsBlood pressureElectrocardiographyHeart failureHeart ratePeer review ePublished: 15 August 2000 Issue Published: 1 September 1995 Copyright & PermissionsCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
TCT-91 1-Year Outcomes From the Multicenter, Prospective Study With the Novel PASCAL Transcatheter Valve Repair System for Patients With Mitral Regurgitation in the CLASP Study
Authors: Saibal Kar, Martin Ng, Scott Lim, Darren Walters, John Webb, Neil Fam, Michael Rinaldi, Robert Kipperman, Azeem Latib, Gideon Cohen, Robert Smith, Konstantinos Spargias, William O'Neill, Ulrich Schäfer, Ted Feldman
Journal: Journal of the American College of Cardiology (2019)
National Health Service
Authors: H. D. F. Fraser
Journal: BMJ (1948)

<h3>Background</h3> It is unclear whether increased pulmonary arterial (PA) reactivity to hypoxia observed in preterm infants who develop chronic lung disease of prematurity (CLD) persists into childhood. <h3>Aim</h3> We assessed and compared PA pulse wave velocity (PWV) in air and after 12% hypoxia using velocity-encoded MRI between children who had CLD in infancy and preterm-born and term-born controls. <h3>Methods</h3> From 67 recruited children, 59 (13 CLD, 21 preterm, 25 term), 9–12-year-old children successfully completed the study. Velocity-encoded phase-contrast MR PA images were acquired breathing air and during breathing 12% hypoxia. PA PWV was derived as the ratio of flow to area changes during early systole. <h3>Results</h3> There were no differences in mean (SD) PA PWV between the groups breathing air (CLD=1.3 (0.4) m/s, preterm control=1.3 (0.4) m/s, term control=1.3 (0.3) m/s)) but increased following hypoxia to 1.9 (0.7) m/s, 1.6 (0.6) m/s and 1.5 (0.5) m/s in CLD, preterm and term groups, respectively. The mean differences (95% CI) for PA PWV between CLD and the preterm and control groups were 0.37 (0.08 to 0.70) and 0.34 (0.05 to 0.70), respectively. There was no difference for change in PA PWV with hypoxia between the two control groups, mean difference 0.23 (−0.2 to 0.3). <h3>Conclusions</h3> Children who had CLD in infancy had increased pulmonary arterial reactivity during hypoxia, thus long-term follow-up is warranted in this population.
Let's Operate.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 1746: Insulin Like Growth Factor Binding Protein-3 (IGFBP-3) Mediates Vascular Repair By HDL Receptor Activation And Sphingosine Kinase (SK-1)/Sphingosine 1-Phosphate (S1P) Dependent Nitric Oxide (NO) Generation
Authors: Sergio Li Calzi, Jennifer L Kielczewski, Evan McFarland, Kyung Hee Chang, Aqeela Afzal, Lynn C Shaw, Yagna Jarajapu, Tailoi Chan-Ling, Maria B Grant
Journal: Circulation (2008)

Purpose: We demonstrated that IGFBP-3 stimulates hematopoietic stem cells (HSC) to differentiate into endothelial cells, form capillaries, and stabilize the vasculature (Chang, et al, PNAS 2007). Local IGFBP- 3 production is increased by hypoxia and facilitates the homing of HSC to areas of injury. In the circulation, IGFBP-3 is bound to HDL. In this study, we investigated the signaling pathways responsible for the robust migratory effects of IGFBP-3. Methods: The effects of IGFBP-3 on NO generation in human vascular precursors (CD 34 + , CD14 − ), human lung microvascular endothelial cells, and human umbilical vein endothelial cells were examined using DAF-FM fluorescence. Western analysis was use for detection of eNOS and vasodilator-stimulated phosphoprotein (VASP), which redistributes to lamellipodia forming an active motor complex that supports motility and is phosphorylated in response to NO. Localization of VASP was performed by immunohistochemistry. SK-1 was assessed following IGFBP-3 stimulation. Results: In CD34 + cells and endothelial cells, IGFBP-3 stimulated eNOS phosphorylation at Ser1177 (102 ± 1.8%, P = 0.0002) and increased NO generation (275 ± 50%, P = 0.05) by increasing SK-1 and S1P generation. IGFBP-3 was bound and internalized by the HDL receptor, scavenger receptor 1B (SR1B). NO generation following IGFBP-3 exposure was reduced by SK inhibitors or SR-1B blocking antibody pretreatment (35 ± 5%, P &lt; 0.02). IGFBP-3 generated NO increased phosphorylation of VASP at Ser239 and promoted the redistribution of VASP to lamellipodia. Conclusions: IGFBP-3 effects on cell migration are NO dependent and mediated in part by activation of the HDL receptor SR1B suggesting that some of the beneficial effects of HDL are mediated by the association of IGFBP-3.
Ocular Adnexal Lymphoma: A Clinicopathological Study of a Large Cohort of Patients with No Evidence for an Association with Chlamydia psittaci.
Authors: Manuel F. Rosado, Gerald E. Byrne, Feying Ding, Keneth A. Fields, Phillip A. Ruiz, Sander R. Dubovy, Gale R. Walker, Arnold Markoe, Lossos S. Izidore
Journal: Blood (2005)
Repair of Mitral Insufficiency Associated with Ruptured Chordae Tendineae
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
DEXA
Authors: Wilhelm Börner
Journal: JAMA (1992)

<h3>To the Editor.</h3> —The issues surrounding dual-energy x-ray absorptiometry (DEXA) may have an impact in Germany, as these devices have been launched in Germany in quite large numbers.<sup>1</sup>As members of the German advisory board for quality assurance in nuclear medicine and radiology instrumentation, we would like to comment on this report. We are able to confirm the figures for the precision of DEXA cited in the article and the specification of its inaccuracies. But we do not agree with the conclusions drawn. For 2½ years we have been using DEXA for comparison during the clinical evaluation of a peripheral quantitative computed tomography (pQCT) system, which was commercialized 4 years ago. The pQCT has met with a large demand in Germany. The method has been well described and clinically evaluated,<sup>2,3</sup>and it is reimbursed by the public health care program. There is now increasing interest in it in
Phosphodiesterase in Psoriasis
Authors: F. Zaruba, M. Karasek, K. Farber
Journal: British Journal of Dermatology (1970)

Journal Article Phosphodiesterase in Psoriasis Get access F. Zaruba, F. Zaruba Stanford University Medical Center California Search for other works by this author on: Oxford Academic Google Scholar M. Karasek, M. Karasek Stanford University Medical Center California Search for other works by this author on: Oxford Academic Google Scholar K. Farber K. Farber Stanford University Medical Center California Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 82, Issue 1, 1 January 1970, Page 90, https://doi.org/10.1111/j.1365-2133.1970.tb02199.x Published: 01 January 1970
Representative sequencing: Profiling extreme tumor diversity
Authors: K. Litchfield, C. Swanton, S. Turajlic
Journal: Annals of Oncology (2018)

Background: While next-generation sequencing (NGS) has been applied to thousands of solid tumors to date, there exists a fundamental undersampling bias inherent in current methodologies. This is caused by a biopsy input sample of fixed dimensions, which becomes grossly under-powered as tumor volume scales. Indeed, analysis of pan-cancer data reveals that current protocols sample on average only 1.5% of cancer cells, decreasing to 0.3% for stage IV tumors. Failure to address this bias risks undermining the clinical utility of genomic medicine in cancer. Methods: Here we demonstrate Representative Sequencing (Rep-Seq), as a novel method to achieve unbiased sampling of solid tumor tissue. The Rep-Seq protocol comprises homogenization of all residual tumor material not taken for pathology into a well-mixed solution, coupled with NGS. Rep-Seq was implemented on a proof of concept basis in > 10 tumors, and benchmarked against single and multi-region sequencing approaches. Results: Rep-Seq achieved a linear rate of novel variant discovery in whole-exome sequencing across 0 to 5,000x coverage, detecting four-fold more mutations as compared to multi-region sequencing at equivalent total read depth. All variants were validated using custom panel and Ion Torrent platforms. Targeted panel Rep-Seq at 50,000x showed sensitivity to detect extreme parallel evolution, with 16 independent mutations in the gene SETD2 observed in a single tumor. Clonal clustering analysis revealed rapid convergence of cancer cell fraction estimates in Rep-Seq towards true values, as validated in > 70 biopsies taken from a single tumor. As a consequence, 97% of variants were correctly classified as clonal by Rep-Seq, compared to > 85% in single biopsy sequencing. Finally, in a rapid autopsy setting Rep-Seq was able to accurately reconstruct the clonal phylogency of advanced stage disease, recovering a high proportion of all primary and metastatic variants, from deep sequencing of primary tissue alone. Conclusions: Rep-Seq effectively implements unbiased tumor sampling, drawing DNA molecules from a well-mixed solution of the entire tumor mass, hence removing spatial bias inherent in current approaches. As a result, Rep-Seq detects more mutations, and achieves greater accuracy in determining clonal from subclonal variants. Legal entity responsible for the study: The Francis Crick Institute. Funding: Roche. Disclosure: C. Swanton: Consulting and speaker fees from Boehringer Ingelheim, Eli Lilly, Novartis, and Roche; Research grants from Roche. S. Turajlic: Research grants from Roche. All other authors have declared no conflicts of interest.
Erratum: Constitutive activation of p38 MAPK in tumor cells contributes to osteolytic bone lesions in multiple myeloma
Authors: J Yang, J He, J Wang, Y Cao, J Ling, J Qian, Y Lu, H Li, Y Zheng, Y Lan, S Hong, J Matthews, M W Starbuck, N M Navone, R Z Orlowski, P Lin, L W Kwak, Q Yi
Journal: Leukemia (2015)
Prophylactic Mastectomy for Familial Breast Cancer
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal