tbuckley/cabot-search huggingface dataset:
Pediatric Orthopedics
Authors: Jonathan Cohen
Journal: JAMA (1991)

<h3>Lovell and Winter's Pediatric Orthopedics, vols 1,2, edited by Raymond T. Morrissy, 3rd ed, 1228 + pp, with 1283 illus, $195, ISBN 0-397-50914-6, Philadelphia, Pa, JB Lippincott, 1990.</h3> Both the four-volume textbook by Tachdjian and the two-volume work edited by Morrissy are new editions. Each has been a standard reference in every library for pediatric orthopedic surgeons in the United States, and the new editions undoubtedly will continue to be popular. There are significant changes in each book that are noteworthy. Tachdjian, in the 18-year interval between editions, has rewritten the entire text and doubled its size, and he now emphasizes his personal preferences as to treatment. Morrissy, having assumed editorial responsibility from Lovell and Winter, has substituted new authors for about half the chapters, has written two of them himself, and has divided up a few of the others. However, the organization of both books has not changed significantly and
ERRATA
Journal: Circulation (1952)

In the article "Surgery for Mitral Stenosis. A Review of Progress," by Dr. Edward F. Bland ( 5: 290, 1952), the following changes should be read in table 2: the footnote "†Operations by Drs. J. G. Scannell and R. Warren" applies to the entry "Author's series (Boston)" rather than to the "Totals." Please note that Dr. Warren has no middle initial.
MEDICAL MOTION PICTURES
Journal: JAMA (1953)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Acidic Sulfate Aerosols: Characterization and Exposure
Authors: Paul J. Lioy, Jed M. Waldman
Journal: Environmental Health Perspectives (1989)

Exposures to acidic aerosol in the atmosphere are calculated from data reported in the scientific literature. The majority of date was not derived from studies necessarily designed to examine human exposures. Most of the studies were designed to investigate the characteristics of the atmosphere. However, the measurements were useful in defining two potential exposure situations: regional stagnation and transport conditions and local plume impacts. Levels of acidic aerosol in excess of 20 to 40 micrograms/m3 (as H2SO4) have been observed for time durations ranging from 1 to 12 hr. These were associated with high, but not necessarily the highest, atmospheric SO4(2)- levels. Exposures of 100 to 900 micrograms/m3/hr were calculated for the acid events that were monitored. In contrast, earlier London studies indicated that apparent acidity in excess of 100 micrograms/m3 (as H2SO4) was present in the atmosphere, and exposures less than 2000 micrograms/m3/hr were possible. Our present knowledge about the frequency, magnitude, and duration of acidic sulfate aerosol events and episodes is insufficient. Efforts must be made to gather more data, but these should be done in such a way that evaluation of human exposure is the focus of the research. In addition, further data are required on the mechanisms of formation of H2SO4 and on what factors can be used to predict acidic sulfate episodes.
Hepatic amyloidosis: Clinical appraisal in 77 patients
Authors: M Gertz
Journal: Hepatology (1997)

The purpose of this study was to assess prognostic factors and survival in patients with liver involvement in immunoglobulin light-chain amyloidosis. Comparisons were made with other patients with immunoglobulin light-chain amyloidosis who did not have liver involvement. A total of 77 consecutively seen patients were evaluated: 19 had hepatic amyloidosis and 58 had amyloidosis without liver involvement. Eighteen of 19 patients with liver amyloidosis could be histologically diagnosed without needle biopsy of the liver. All but 2 had a detectable free light chain in the serum or urine, distinguishing this from other infiltrative liver processes. Patients with liver amyloid had significantly higher alkaline phosphatase levels and C-reactive protein levels compared with patients without hepatic amyloid. The majority of patients had extrahepatic involvement predominantly in the kidney (47%) or heart (42%). The presence of hyposplenism was not a good screening test for the presence of hepatic amyloid. Seven of 19 patients responded to chemotherapy with objective regressions of the clinical manifestations of renal, hepatic, or cardiac involvement. We conclude that the survival of patients with liver involvement in amyloidosis is no different than other patients with amyloidosis. This results from the high proportion of patients having associated renal or cardiac involvement. Most patients can be diagnosed without a liver biopsy when a monoclonal protein is found in the serum or urine. Serum albumin and C-reactive protein levels appear to distinguish patients with liver involvement from those without.
Abstract 296: Fibroblast Proliferation Dynamics in the Mouse Heart with Myocardial Infarction Injury <i>in vivo</i>
Authors: Xing Fu, Onur Kanisicak, Hadi Khalil, Jeffery Molkentin
Journal: Circulation Research (2017)

After MI, dead cardiomyocytes are permanently replaced by scar tissue mainly composed of fibroblasts and extracellular matrix (ECM) proteins due to the lack of cardiomyocyte regeneration. Previous attempts to characterize fibroblasts after MI were greatly hindered by the lack of specific cardiac fibroblast markers. By employing newly established mouse lines with the Tcf21 locus-driven MerCreMer cDNA or Postn locus-driven MerCreMer cDNA, which when used with a loxP-dependent genetic reporter line will lineage trace either all resident cardiac fibroblasts and all activated cardiac fibroblasts, respectively. Here we show that upon MI injury, cardiac fibroblasts within the area of injury were quickly activated and showed dramatic increases in cellular proliferation followed by an overlapping differentiation phase, resulting in a large number of smooth muscle α-actin (αSMA) positive myofibroblasts within the developing scar region. However, αSMA + cardiac fibroblasts were no longer observed by 2 weeks post MI, although collagen deposition increased significantly. Lineage tracing indicates that loss of αSMA + fibroblasts within the stabilized scar was due to the loss of αSMA expression in these lineage traced and differentiated fibroblasts, rather than due to their apoptosis. Moreover, additional stimulation of these activated fibroblasts within the stable scar with Angiotensin II - phenylephrine osmotic pumps, which robustly induces new fibroblasts to differentiate and express αSMA in previously uninjured hearts, was not able to re-activate or induce proliferation of the fibroblasts within the scarred region 4 weeks post MI, which suggests that these cardiac fibroblasts were not fully dedifferentiated. We proposed that αSMA + myofibroblasts are unique to the early post MI stage in providing structural support before the collagen matrix and additional ECM is fully matured. We will present the results of RNA-sequencing of cardiac fibroblasts isolated from the scar region at different post MI stages to show their more stable intermediate stages.
Abstract 488: Direct real-time visualization and quantification of T cell receptor dynamics
Authors: Jillian N. Rosenberg, Guoshuai Cao, Fernanda Borja-Prieto, Yanran He, Hans Schreiber, Jun Huang
Journal: Cancer Research (2019)

Abstract The mechanism by which a T cell utilizes its T-cell receptors (TCRs) to recognize foreign peptide major histocompatibility complexes (pMHCs) has not yet been fully deciphered. Much contention still exists surrounding TCR nanostructures before, during, and after synapse formation. Accurate measurements of single TCR location, diffusion/trafficking, clustering, and signaling at the live T-cell membrane have been hindered by the microscopy techniques available. Recently developed Lattice Light-Sheet Microscopy uses a structured light sheet to excite fluorescence in successive planes of a living T cell such that it can record 4D (x, y, z directions and time) images with exceptionally high temporal resolution (10ms/frame, ~1s/volume), finally allowing for precise single molecule tracking. Here we show that TCRs pre-exist in small microclusters prior to synapse formation in both naïve and stimulated resting CD4+ T cells. These clusters are very fast-moving, explaining the previous difficulties of tracking TCR motion and revealing a fast responding mechanism for antigen recognition. Upon encountering antigens, these smaller TCR nanoclusters traffic globally and quickly to the cell interface, aggregate into larger microclusters, and form the immunological synapse. Finally, we compare and contrast the receptor dynamics of CAR-T cells with those of naturally occurring T cell receptors. These findings precisely quantify TCR and CAR dynamics three-dimensionally, suggesting new mechanistic details of the speed and accuracy of TCR signaling and providing new information upon which to base future immunotherapies. Citation Format: Jillian N. Rosenberg, Guoshuai Cao, Fernanda Borja-Prieto, Yanran He, Hans Schreiber, Jun Huang. Direct real-time visualization and quantification of T cell receptor dynamics [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 488.
THE ACTION OF DIGITALIS ON THE HEART.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Xylose test.
Authors: R Schneider, R D Montgomery, H G Sammons
Journal: BMJ (1973)

were disappointed that one of the first pro- tagonists of active management had not taken the opportunity to eamine this Question more closely.kt would be interesting to ca~are fetal heart rate changes, scalp blood samples, incidence of caesarean section for fetal distress, condition of the fetus at birth, perinatal mortality, and the resuts of an early neurological and developmental assessment on all babies in a grup of mothers and fetuses given oxytocin with a matched group before the policy of active management was insituted.In the context of infection we were suirprised that in 63 patients 24 hours were allowed to elapse after amniotcmny before giving oxytocin,2 particularly as one baby was lost from infection in the induction of labour group.We agree with Professor O'Driscoli that active management of labour is a logical ex- tension of modern techniques, but we feel that the indications for intervention in labour might be better defined if the above data were availale.-Weare, etc.,
Chronic thromboembolic pulmonary hypertension
Authors: P. Dartevelle, E. Fadel, S. Mussot, A. Chapelier, P. Hervé, M. de Perrot, J. Cerrina, F.L. Ladurie, D. Lehouerou, M. Humbert, O. Sitbon, G. Simonneau
Journal: European Respiratory Journal (2004)

Pulmonary arterial hypertension is a severe disease that has been ignored for a long time. However, over the past 20 yrs chest physicians, cardiologists and thoracic surgeons have shown increasing interest in this disease because of the development of new therapies, that have improved both the outcome and quality of life of patients, including pulmonary transplantation and prostacyclin therapy. Chronic thromboembolic pulmonary arterial hypertension (CTEPH) can be cured surgically through a complex surgical procedure: the pulmonary thromboendarterectomy. Pulmonary thromboendarterectomy is performed under hypothermia and total circulatory arrest. Due to clinically evident acute-pulmonary embolism episodes being absent in > 50% of patients, the diagnosis of CTEPH can be difficult. Lung scintiscan showing segmental mismatched perfusion defects is the best diagnostic tool to detect CTEPH. Pulmonary angiography confirms the diagnosis and determines the feasibility of endarterectomy according to the location of the disease, proximal versus distal. The technique of angiography must be perfect with the whole arterial tree captured on the same picture for each lung. The lesions must start at the level of the pulmonary artery trunk, or at the level of the lobar arteries, in order to find a plan for the endarterectomy. When the haemodynamic gravity corresponds to the degree of obliteration, pulmonary thromboendarterectomy can be performed with minimal perioperative mortality, providing definitive, excellent functional results in almost all cases.
Request for Comments on Policy on Promotion of Unapproved Uses
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PENSIONS FOR PHYSICIANS
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Use of the hospital in a randomized trial of prepaid care
Authors: A. L. Siu
Journal: JAMA (1988)

Health maintenance organizations (HMOs) achieve their cost savings through lower rates of hospital admissions. To determine whether HMOs selectively avoid discretionary hospitalizations, medical records were reviewed from a randomized trial where families were assigned to either HMO or fee-for-service care. Physicians who were blinded to system reviewed 244 medical records and judged the appropriateness both of the hospital setting and of the medical indications for hospitalization. The rate of discretionary surgery was lower in the HMO, while the rate of nondiscretionary surgery was equivalent in the two systems. For medical admissions, rates of discretionary and nondiscretionary admissions were lower in the HMO. There were no observable adverse effects on health from the lower rates of nondiscretionary hospitalization, either because the net effect on health was small or because the HMO substituted appropriate ambulatory services. We conclude that HMO reductions in hospitalization rates do not occur "across the board"; discretionary surgery is selectively avoided. (<i>JAMA</i>1988;259:1343-1346)
Abstract 143: Immune landscape in lung adenocarcinoma drawn by single-cell RNA sequencing
Authors: Bo Mi KU, Nayoung Kim, Kyung Young Lee, Jong-Mu Sun, Se-hoon Lee, Jin Seok Ahn, Keunchil Park, Hong Kwan Kim, Hae-Ock Lee, Myung-Ju Ahn
Journal: Cancer Research (2019)

Abstract Immune cells in the tumor microenvironment from an ecosystem that modulates cancer progression. However, the exact nature and dynamics of tumor microenvironment in lung cancer remain largely unknown. To depict the baseline landscape of the composition of tumor microenvironment at different stages, we conduceted single-cell RNA sequencing of 58 samples from 43 lung adenocarcinoma patients. Here, we analyzed 11 early-stage lung tumor and normal pairs that had been resected before systemic therapy, 11 late-stage lung tumor biopsy, and 5 metastatic pleural-effusion or 10 metastatic brain tumor samples and revealed differential immune profiles encompassing lymphoid and myeloid compartment. In normal lung, large numbers of macrophages and T cells consistently comprised the immune cell repertoire across patients. In paired cancer tissues, decrease in macrophage but increase in B cell proportions were evident indicating the activation of humoral immunity. In addition, diverse effector T cell populations mark the cancer tissues both at the primary and metastatic sites, corroborating the activation of cellular adaptive immunity. These data provide valuable insight of tumor-driven immune changes in lung cancer. Citation Format: Bo Mi KU, Nayoung Kim, Kyung Young Lee, Jong-Mu Sun, Se-hoon Lee, Jin Seok Ahn, Keunchil Park, Hong Kwan Kim, Hae-Ock Lee, Myung-Ju Ahn. Immune landscape in lung adenocarcinoma drawn by single-cell RNA sequencing [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 143.
Manuscripts Approved for JNCI, January 15 to February 15, 1961
Journal: JNCI Journal of the National Cancer Institute (1961)

Manuscripts Approved for JNCI, January 15 to February 15, 1961 Get access JNCI: Journal of the National Cancer Institute, Volume 26, Issue 3, March 1961, Page 784, https://doi.org/10.1093/jnci/26.3.784-a Published: 01 March 1961
Facing It
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
“Community-acquired pneumonia in younger patients is an entity on its own.” Benjamin Klapdor, Santiago Ewig, Mathias W. Pletz, Gernot Rohde, Hartwig Schütte, Tom Schaberg and Tobias Welte for the CAPNETZ study group.<i>Eur Respir J</i>2012; 39: 1156–1161.
Journal: European Respiratory Journal (2012)

We regret that throughout the above manuscript, the term ''CURB-65'' was incorrectly used instead of the correct term ''CRB-65''.All affected sentences are corrected as follows.Page 1156; abstract, third paragraph: Most younger patients presented with mild CAP (74.0% had a CRB-65 score of 0 (confusion of new onset, respiratory rate of o30 breaths?min -1 , blood pressure ,90 mmHg or diastolic blood pressure f60 mmHg, age o65 yrs)).Page 1157; Methods section, fourth subsection: CRB-65 score and mortality The CRB-65 score (confusion of new onset, respiratory rate of o30 breaths?min -1 , systolic blood pressure ,90 mmHg or diastolic blood pressure f60 mmHg, age o65 yrs) was determined in all patients.One point is given for each parameter present, which results in CRB-65 scores of 0-4.For each patient, the CRB-65 score was calculated with patient data assessed at first presentation.Page 1157; Results section, second paragraph: The distribution of CRB-65 risk classes (in patients with complete data sets) was as follows: CRB-65 score of 0 in 34.3% (n52,677), 1-2 in 50.6% (n53,945) and 3-4 in 4.2% (n5328) of patients.Page 1158; first column, fourth paragraph: CRB-65 risk class distribution was very similar across all younger decades (72-75% risk class 1, 24-28% risk class 2 and ,1% risk class 3).Page 1158; second column, final paragraph: CRB-65 score was determined as 0 in three, as 1-2 in four and as 3-4 in one of them.Page 1160; second column, third paragraph: First, younger patients were hospitalised in nearly 50% of cases, despite the fact that around 75% of patients had a CRB-65 score of 0. ERRATUM ''Reproducibility of 6-minute walking test in patients with COPD''.N.