tbuckley/cabot-search huggingface dataset:
Effects of density and of dehydration of sickle cells on their adhesion to cultured endothelial cells
Authors: P.C.W. Stone, J. Stuart, G.B. Nash
Journal: American Journal of Hematology (1996)

Abnormal adhesion of sickle cells to vascular endothelium may be a factor in the initiation of painful vaso-occlusive crisis. The sickle cell population contains an unusually large number of less dense reticulocytes that are known to be more adhesive than mature red cells, but there is contradictory evidence regarding the adhesiveness of dense sickle cells. We used a flow-based assay of adhesion to cultured human umbilical vein endothelial cells to test the properties of density fractions of sickle cells, prepared either by density gradient or by centrifugation of packed cells. We also examined the effects of incubating sickle cells with or without cyclical deoxygenation on their adhesion. After fractionation on a Percoll-Isopaque gradient, the less dense 10% (reticulocyte-rich) cells and the most dense 10% cells adhered in greater number than the remainder (by about twofold). However, after centrifugation of packed cells, the less dense 10% were again more adhesive than the "middle" cells, but the most dense were not. Exposing sickle cells to constituents of the gradient had no consistent effect on adhesion, while centrifugal packing induced a degree of hemolysis, and tended to reduce adhesiveness of the dense fraction previously obtained from a gradient. Incubation in air at 37°C for 15 hr reduced the number of reticulocytes and the adhesiveness of less dense sickle cells compared to those held at 4°C. On the other hand, incubation at 37°C for 15 hr with cyclical deoxygenation caused formation of dense cells and increased adhesiveness compared to incubation without cyclical deoxygenation. We conclude that young, less dense sickle cells are unusually adhesive, but that this adhesiveness is reduced during maturation. However, repeated sickling in vivo causes formation of an abnormally dense subpopulation of cells which either redevelop an increased tendency to adhere to endothelial cells or preserve their initial adhesiveness. Both adhesive cell populations may be implicated in promoting vascular obstruction. © 1996 Wiley-Liss, Inc.
Progressive type of focal nodular hyperplasia characterized by multiple tumors and recurrence
Authors: D SADOWSKI
Journal: Hepatology (1995)

Focal nodular hyperplasia (FNH) is usually a stable lesion that does not enlarge when studied for long periods of time; recurrence after resection has not been reported. We present a patient with a solitary FNH lesion that enlarged, was resected, and then recurred. A second resection was performed because of abdominal pain and disclosed multiple lesions, two of which were acutely infarcted. Thirty-two months later there was ultrasound evidence of further recurrence. Histology of the lesions showed the usual appearance of FNH with ducts and ductules in the central stalk regions but also some areas with minimal ductular differentiation and scanty connective tissue. Because of the clinical and histological appearance, the lesions in this patient were distinct from the usual type of FNH and merit the name "focal nodular hyperplasia, progressive type." (HEPATOLOGY 1995; 21:970–975.)
Cancer Research, Chicago
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
POLYCYTHEMIA.
Authors: J. F. ALDRICH
Journal: JAMA (1907)

The recent exhaustive articles<sup>1</sup>on this subject have changed our plans in considering the condition in detail and referring to the previous work which has been done on this subject, but cases are still so rare that we think it expedient to report this one in considerable detail. This case seems of especial interest in that while it has the entire triad of symptoms completely developed, it differs in some important essentials from the cases previously reported. <h3>Patient.</h3> —Mrs. J. M. D., aged 53, first seen by Dr. Aldrich Jan. 11, 1906, complained of considerable dyspnea on exertion. She had also noticed that she had an immense growth in the left abdomen. <h3>Family History.</h3> —This was negative. The father was living at the age of 86, and was in reasonably good health. The mother died at 50, from a "lingering consumption." The patient had waited on her mother constantly
Computed tomography in the diagnosis of pelvic abscesses in renal transplant patients
Authors: M. J. Bia
Journal: JAMA (1981)

Two renal transplant patients had fever and graft tenderness secondary to a gas-containing abscess around the transplanted kidney. Renal ultrasonography failed to identify the abscess in these cases because of the difficulty in differentiating bowel from gas-containing collections. Gallium citrate Ga 67 scanning, performed in one patient, did not delineate the abscess because interpretation was complicated by the presence of radioactivity in the bowel. In both cases, the pelvic abscess was identified correctly with the use of computed tomography (CT). The limitations of ultrasonography in identifying gas-containing collections should be recognized, and CT should be performed as one of the initial studies in evaluating a renal transplant patient with a suspected pelvic abscess. (<i>JAMA</i>1981;246:1435-1437)
Toxicology of Organic Drinking Water Contaminants: Trichloromethane, Bromodichloromethane, Dibromochloromethane and Tribromomethane
Authors: Albert E. Munson, Larry E. Sain, Virginia M. Sanders, Bernadine M. Kauffmann, Kimber L. White, Dennis G. Page, Donald W. Barnes, Joseph F. Borzelleca
Journal: Environmental Health Perspectives (1982)

This study evaluated the subchronic toxicity of selected halomethanes which are drinking water contaminants. The compounds studied were trichloromethane, bromodichloromethane, dibromochloromethane and tribromomethane. Subchronic 14-day gavage studies were performed with the use of doses encompassing one-tenth the LD50 for the compounds. A 90-day gavage study of one of the compounds, trichloromethane, was also done. Parameters observed included body and organ weights, histopathology, hematology, clinical chemistries, and hepatic microsomal enzyme activities. Toxicity to the humoral immune system was assessed by measuring the number of splenic IgM antibody-forming cells and the serum antibody level to sheep erythrocytes. Cell-mediated immunity was evaluated by measuring the delayed type hypersensitivity response and popliteal lymph node proliferation response to sheep red blood cells. The functional activity of the reticuloendothelial system, as measured by the vascular clearance rate and tissue uptake of 51Cr sheep red blood cells was also determined. The major effects of the halomethanes were increased liver weights, elevations of SGPT and SGOT, decreased spleen weights and a decrease in the number of splenic IgM antibody-forming cells. The humoral immune system appeared to be an indicator of halomethane toxicity. There is evidence that subchronic 14-day exposure may be of greater value than long-term studies in determining the toxicity of these compounds.
Antibiotic Accountability
Authors: Calvin M. Kunin
Journal: New England Journal of Medicine (1979)

Medical practice in the 1970's is caught in the bind between advances in technology and the demand for accountability. Drug usage, particularly antibiotic usage, is a highly visible segment of medical progress. Antibiotics differ from other drugs in that they not only exert a therapeutic effect but also alter the ecology of the microflora of the body and the environment. Thus, antibiotic usage conjures up an image of fallout akin to that from a leaking nuclear reactor. There is legitimate concern about the development of antibiotic resistance and its transmission by plasmids as a result of excessive use of antibiotics . . .
Hygiene of Pregnancy.
Journal: JAMA (1910)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hepatocarcinogenesis is the sequel to hepatitis in Z#2 α1-antitrypsin transgenic mice: Histopathological and DNA ploidy studies
Authors: S Geller
Journal: Hepatology (1994)

Z mutant–associated α1-antitrypsin deficiency in human beings leads to hepatitis and, in some cases, hepatocellular carcinoma. To begin to delineate the molecular basis for the development of hepatocellular carcinoma in α1-antitrypsin deficiency, we previously developed transgenic mice using human α1-antitrypsin M and Z genomic clones. High-copy Z lineage mice (12 gene copies/haploid mouse genome; "Z#2") had hepatocytes distended with human α1-antitrypsin deficiency globules. Hepatitis was present, and the morphological changes mimicked those observed in human α1-antitrypsin deficiency-related liver disease. The numbers of hepatocytes containing α1-antitrypsin globules decreased with age, and α1-antitrypsin-negative nodular aggregates of hepatocytes increased in number and size. Hepatocytic dysplasia occurred as early as 6 wk and was almost universally present at 1 yr. Nodules of dysplastic cells demonstrating aneuploidy were seen as early as 10 wks. These became persistent, proliferative lesions. Dysplasia and aneuploidy distinctly increased with time and advancing microscopic stage as lesions progressed to malignancy. Tumors were seen after 1 yr as adenomas, which are aneuploid and most likely well-differentiated hepatocellular carcinoma, and borderline malignant lesions; and, in 82 of Z#2 mice 16 to 20 mo old, as invasive hepatocellular carcinoma. These observations suggest but do not conclusively prove that hepatocellular carcinoma in α1-antitrypsin deficiency and other hepatic disorders arises as a result of a common, endogenously stimulated pathway for hepatocellular carcinogenesis. (Hepatology 1994;19:389–397).
Aggressive lymphoma
Authors: M Merli, M Spina, S Luminari, C Stelitano, V Ferretti, C Gabutti, C Targhetta, C Visco, A Levis, D Rossi, L Rigacci, A Ambrosetti, A Chiappella, P Musto, L Arcaini, A Gang, M Pedersen, F D'amore, L Pedersen, A Bukh, B Pedersen, M Moeller, O Gadeberg, S Ingeberg, T Mourits-Andersen, S Pulczynski, T Klausen, P Brown, J Yarber, S Otis, B Robinson, L Gordon, J Winter, R Advani, A Evens, F Nicholson, N Maka, R Jackson, M Leach, P Mckay, E Pardal, C Grande, A Martı, A Marı ´n-Niebla, C Panizo, E Conde, J Bello, M He ´rnandez, E Pe ´rez, E Go ´nzalez-Barca, R Arranz, J Bargay, M Ramı ´rez, A Salar, M Canales, M Caballero, H Takahashi, N Tomita, M Yokoyama, S Tsunoda, T Yano, K Murayama, C Hashimoto, K Tamura, K Sato, Y Ishigatsubo
Journal: Annals of Oncology (2011)
Concentrated Swine Feeding Operations and Public Health: A Review of Occupational and Community Health Effects
Authors: Dana Cole, Lori Todd, Steve Wing
Journal: Environmental Health Perspectives (2000)

Recent industry changes in swine-management practices have resulted in a growing controversy surrounding the environmental and public health effects of modern swine production. The numerous wastes produced by intensive swine production not only pose a significant challenge to effective environmental management but also are associated with decreased air quality in confinement houses, potentially transferable antimicrobial resistance patterns, and several infectious agents that can be pathogenic to humans. Published studies have documented a variety of contaminants, microbial agents, and health effects in those occupationally exposed to swine, and these have provided the groundwork for an increasing body of research to evaluate possible community health effects. Nonetheless, several factors limit our ability to define and quantify the potential role of intensive swine-rearing facilities in occupational and community health. Our incomplete understanding and ability to detect specific exposures; the complicated nature of disease etiology; pathogenesis; and surveillance; and the inherent difficulties associated with study design all contribute to the inadequate level of knowledge that currently prevails. However; an evaluation of the published literature; and a recognition of the elements that may be compromising these studies; provides the foundation from which future studies may develop.
Operation Smile Volunteers Travel Far to Transform Lives
Authors: D. F. Phillips
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Incorrect Sentence.
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Issue Information
Journal: Medicinal Research Reviews (2019)

The journal publishes timely critical reviews of topics related to medicinal research, broadly defined, to which the authors have made significant contributions.Appropriate topics include, but are not limited to, the underlying pathophysiology of important diseases and disease vectors; therapeutic approaches to the treatment of various diseases; the properties of molecular targets for therapeutic agents; important new methodologies facilitating the search for therapies; genomics and proteomics; structure-activity correlations of drug series; the development of new imaging and diagnostic tools; drug metabolism; drug delivery; and chemical, pharmacological, pharmacokinetic, pharmacodynamic, and clinical characteristics of important drugs.Articles are mainly solicited by the editors; however, voluntary contributions are also encouraged.In the latter case, potential authors are asked to contact the Editor-in-Chief with an outline before beginning to write in order to avoid duplication of effort and to ensure suitability of the topic and the level of coverage.
Clinical Practice of Transfusion Medicine
Authors: Edgar J. Pierce
Journal: JAMA (1997)

This third edition of<i>Clinical Practice of Transfusion Medicine</i>continues its previously established tradition of being a teaching text and ready reference. Having read, reviewed, and used the two previous editions, I feel comfortable now with where the editors are going. Much as the branch of science about which they write, they are adding small increments of improvement. The major writers, Petz and Swisher, admit in the overview that even though "present technologies still can be substantially improved... one must now examine the marginal value of these improvements." This seems to reflect the thinking of our day. If the technological jump is not to hyperspace, it is deemed hardly worth the financial effort. Nonetheless, the authors did persist in their own efforts not to succumb to such thinking. They add new editors, authors, and topics to this edition. They have maintained the backbone of reference and biological data. The major
The concept of stratified medical care
Authors: I. S. Wright
Journal: JAMA (1972)

There appears to be emerging a remarkable unanimity from both professional and public sources that medical service must be reorganized in the immediate future. The simple approach which first occurs to some is to provide more funds in the hopes of quickly producing medical facilities and personnel and greatly improved medical service. Those who are experienced in this problem recognize that funding is indeed essential but that instant results are not to be expected. It takes years and not months to train physicians, nurses, and technical personnel. It also takes many months, often several years, to plan, fund, and develop new or renovated facilities and to assemble and pretest the rather complex equipment and units now considered essential for modern medical care. In order to provide quality care for large numbers of our population, considerable restructuring of the use of our resources will be essential. For the past three years
A TRAVELING POST-GRADUATE SCHOOL.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Apolipoprotein E type 4 allele and cerebral glucose metabolism in relatives at risk for familial Alzheimer disease
Authors: G. W. Small
Journal: JAMA (1995)

<h3>Objective.</h3> —Cerebral parietal hypometabolism and left-right asymmetry occur early in the course of Alzheimer disease (AD), and the apolipoprotein E type 4 alal- (<i>APOE</i>ε4) is a risk factor for familial AD. To determine if<i>APOE</i>ε4 is associated with lowered brain function in nondemented relatives at risk for familial AD, we studied 12 relatives with<i>APOE</i>ε4 and 19 relatives without<i>APOE</i>ε4. We also compared them with seven patients with probable AD. <h3>Design.</h3> —After grouping subjects according to diagnosis and genotype, brain function measures were compared among groups. <h3>Setting.</h3> —University medical center. <h3>Patients.</h3> —At-risk subjects had mild memory complaints, normal cognitive performance, and at least two relatives with AD. Subjects with<i>APOE</i>ε4 did not differ from those without<i>APOE</i>ε4 in mean age at examination (56.4 vs 55.5 years) or in neuropsychological performance (mean Mini-Mental State Examination score, 28.8 vs 29.3). <h3>Main Outcome Measures.</h3> —Cerebral glucose metabolism was measured using positron emission tomography and fludeoxyglucose F 18. <h3>Results.</h3> —Parietal metabolism was significantly lower and left-right parietal asymmetry was significantly higher in at-risk subjects with<i>APOE</i>ε4 compared with those without<i>APOE</i>ε4. Patients with dementia had significantly lower parietal metabolism than did at-risk subjects with<i>APOE</i>ε4. <h3>Conclusions.</h3> —These results suggest that the inheritance of<i>APOE</i>ε4 is associated with reduced cerebral parietal metabolism and increased asymmetry in nondemented relatives at risk for probable AD. Longitudinal study will determine if glucose metabolic measures provide a means to monitor experimental treatment responses during the early phases of the disorder. (<i>JAMA</i>. 1995;273:942-947)