tbuckley/cabot-search huggingface dataset:
Biochemistry, Washington
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bacteroides Empyema.
Authors: Dorsett D. Smith
Journal: Annals of Internal Medicine (1968)

s1 May 1968Bacteroides Empyema.Dorsett D. Smith, M.D., F. R. Fekety, M.D.Dorsett D. Smith, M.D.Search for more papers by this author, F. R. Fekety, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-68-5-1176_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe association of pleural effusion with bacteroides empyema has not been previously noted. We have studied 20 patients with bacteroides empyema and have noted the heralding of this disease by a pleural effusion in 15 of 20 cases. Most patients presented with a history of a smoldering pleural disease associated with several weeks of pleurisy, cough, malaise, night sweats, fever, and weight loss. The pleural effusions were frequently present for weeks before the diagnosis of bacteroides empyema was made. These patients were symptomatic an average of 15 weeks and in the hospital an average of 3.6 weeks before diagnosis. Nine... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Baltimore, Maryland PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByInfections Due to Non-Clostridial AnaerobesPercutaneous Transtracheal Aspiration in the Diagnosis of Anaerobic Pulmonary InfectionJOHN G. BARTLETT, M.D., JON E. ROSENBLATT, M.D., F.A.C.P., SYDNEY M. FINEGOLD, M.D., F.A.C.P. 1 May 1968Volume 68, Issue 5Page: 1176-1177KeywordsBacteroidesFeversPleural effusionSweatWeight loss Issue Published: 1 May 1968 PDF DownloadLoading ...
Emerging Zoonoses
Authors: Myron G. Schultz
Journal: New England Journal of Medicine (1983)

Our well-being depends on our association with animals that share our environment. From cereals, pastures, and crop residues that cannot be digested by human beings, cattle, sheep, and goats produce valuable proteins and fats. Cattle, buffalo, horses, camels, yaks, and llamas still provide most of the world's draft power.1 Fish and game animals supply a large amount of protein for people in developing countries. Nonfood animal products, such as wool, leather, and insulin, help to clothe and sustain us. And pet animals provide us with companionship and an outlet for the expression of kindness and love, without the risk of . . .
Induction of sensitivity to ganciclovir in human hepatocellular carcinoma cells by adenovirus-mediated gene transfer of herpes simplex virus thymidine kinase*1
Authors: C QIAN
Journal: Hepatology (1995)

We have analyzed the ability of a recombinant replication-defective adenovirus to transfer the thymidine kinase gene of herpes simplex virus (HSV-tk) into hepatocellular carcinoma (HCC) cells to confer sensitivity to ganciclovir. Three HCC cell lines (Hep3B, PLC/PRF/5, and HepG2) were efficiently infected in vitro by a recombinant adenovirus carrying lacZ reporter gene (AdCMV1acZ). Expression of HSV-tk in HCC cells infected with a recombinant adenovirus carrying HSV-tk gene (AdCMVtk) induced sensitivity to ganciclovir in a dose-dependent manner. A bystander killing effect was observed when 90% of uninfected tumor cells were mixed with only 10% of AdCMVtk-infected cells. These data show that recombinant adenoviruses are efficient vectors for transduction of drug-sensitizing genes to HCC cells in vitro. We suggest that a gene therapy approach to hepatocellular carcinoma can be established using adenoviral transfer of HSV-tk to tumor cells and subsequent administration of ganciclovir.
A Text book on Practical Therapeutics, with especial reference to the application of remedial measures to disease.
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Disruption of dominant B cell/plasma cell clones in rheumatoid arthritis synovium by rituximab correlates with treatment response
Authors: ME Doorenspleet, PL Klarenbeek, MJ Boumans, RM Thurlings, RE Esveldt, BD van Schaik, AH van Kampen, DM Gerlag, F Baas, PP Tak, RM Plenge, N de Vries
Journal: Annals of the Rheumatic Diseases (2012)

<h3>Background</h3> Autoreactive B lymphocytes are thought to play an important role in rheumatoid arthritis (RA). B cell depletion therapy by rituximab (RTX) has shown that targeting the humoral immune response can result in clinical improvement. Unfortunately, repopulation of B cells leads to disease relapse. Hence, analysis of the B cell/plasma cell compartment in synovium (ST) in patients undergoing RTX therapy might help to identify autoreactive cells responsible for disease persistence and relapse. <h3>Objectives</h3> To compare the B cell/plasma cell repertoire in ST at baseline, 4 weeks and 16 weeks after RTX treatment using a newly developed next-generation sequencing protocol. <h3>Methods</h3> Nine RA patients were included and treated with two intravenous infusions of 1000 mg RTX without additional methylprednisolone. At baseline, all patients fulfilled ACR criteria for RA, were ACPA+ and had a Disease Activity Score 28 (DAS28) &gt;3.2. At week 24, all patients demonstrated moderate EULAR responses. mRNA was isolated from consecutive samples and full-repertoire analysis of the immunoglobulin heavy-chain was performed with primers for all V(ariable)-genes. All amplified products encoded the CDR3, a unique sequence that defines a unique clone. The number of sequences reflects the amount of immunoglobulins produced by that clone and can be used as a measure for 'dominance' of that particular clone. The samples were analysed using a GS-FLX/454 and custom bioinformatics algorithms (&gt;10 000 sequences/sample). Clones with a frequency of &gt;0.5% were arbitrarily considered as dominant clones. <h3>Results</h3> Clones were detected in equal numbers at baseline and 4 weeks after RTX. However, after 16 weeks there was a significant decrease in the number of non-dominant clones compared to baseline (mean −47.7%, p=0.03). In line, the number of dominant clones significantly increased compared to baseline (mean +55.3%, p=0.04). In five patients 17.9% of the dominant clones at baseline was detectable after 16 weeks (mean, SD 8.0%), half of these were dominant at both time points (mean 8.8%, SD 4.6%). In the remaining four patients dominant clones at baseline were not retrieved 16 weeks after RTX. Interestingly, the latter group showed a better response to treatment as determined by a decrease in DAS28 score (r2=0.51, p=0.03). <h3>Conclusion</h3> Our observations suggest a disruption of dominant clones and a repopulation of distinctly different clones 16 weeks after rituximab. The persistence of dominant clones was associated with decreased treatment response. Further study of persisting dominant clones, especially during disease relapse, might help to identify and characterise disease-associated B cells and/or plasma cells.
Early interventions to prevent psychosis: systematic review and meta-analysis
Journal: BMJ (2013)

The upper confidence interval for Morrison 2011 should have read -0.07 (not "0.07") and the lower confidence interval for Van der Gaag 2012 should have read -0.27 (not "0.27").Also, two of the studies were mixed up in the forest plot, which means that the point estimate for Morrison 2011
Clinical phonocardiography. 3. Its use in diagnosis of idiopathic hypertrophic subaortic stenosis
Authors: M. E. Tavel
Journal: JAMA (1968)

Phonocardiography, in conjunction with external pulse tracings, can often be decisive in the diagnosis of idiopathic hypertrophic subaortic stenosis (IHSS). This disease has been recognized with considerable frequency in recent years,<sup>1</sup>and it is incumbent upon the clinician to familiarize himself with its various manifestations. Idiopathic hypertrophic subaortic stenosis is characterized by hypertrophy of the entire left ventricle with particular involvement of the interventricular septum in the region of the outflow tract. Subaortic obstruction is a dynamic process, and the stenosis occurs only after the left ventricle has contracted sufficiently to bring into approximation the thickened walls of its outflow tract. For this reason, the stenosis may vary in severity from time to time, and maneuvers which increase the vigor of ventricular contraction or which enhance left-ventricular emptying will increase the subaortic obstruction. As a result of the subaortic stenosis, a midsystolic, crescendodecrescendo (diamond-shaped) murmur is produced which is
Long-term study evidence accumulating, but radial keratotomy controversy continues
Authors: T. F. Kirn
Journal: JAMA (1987)

THE LONG-TERM research evidence concerning radial keratotomy—the ocular surgical procedure for correcting myopia by the use of four, six, or eight radial incisions in the cornea—continues to come in, but that information is unlikely to quell the debate and controversy surrounding the procedure. According to George O. Waring, III, MD, FACS, the director of the Prospective Evaluation of Radial Keratotomy (PERK) study, the new evidence is "both good and bad news." Three-year follow-up results from the PERK study, announced at the most recent annual meeting of the American Academy of Ophthalmology, in New Orleans, found very few potentially blinding complications (1%); but it also found that it is still difficult to predict how much visual correction will be achieved after the surgery (<i>Arch Ophthalmol</i>1987;105:37-39, 42-51, 86-92). The followup looked at 410 patients from nine major eye centers. The one-year PERK results had indicated that radial keratotomy did diminish myopia (the
Variety of roles for molecular genetics in dealing with cardiovascular disease
Authors: P. Cotton
Journal: JAMA (1993)

GENETICS, one of medicine's leading hopes for advancement, is initiating what promises to be a slow assault on the leading killer, heart disease. More than 5% of all cataloged genes affect the heart in some way, notes Reed E. Pyeritz, MD, PhD, chair of human genetics at the Allegheny Singer Research Institute, Pittsburgh, Pa. So "hundreds of genes are likely to be important in the development and normal physiology of the cardiovascular system," says Pyeritz, who moderated a symposium on cardiovascular molecular genetics at the American Society of Human Genetics meeting in New Orleans, La. Most forms of heart disease appear to be multifactorial, with environmental risk factors as important, if not more so, than the initial conditions set down by genetics. But for rarer forms of heart disease, which have clear and concise genetic causes, the prospects for effective gene therapy seem good. <h3>Preliminary Success</h3> A human trial of
LYCOPERSICUM CARDIOPATHIA.
Authors: W. T. ENGLISH
Journal: JAMA (1896)

The lycopersicum esculentum, natural order of solanaceae, indigenous to South America, is a vining plant with irregular sessated leaves, bearing fruit of various shapes and colors. It is also known as the "love apple," but more commonly is called the "tomato." It was introduced into America in the latter part of the sixteenth century as an ornamental natural curiosity, and was found only in the conservatories of the wealthy. On account of its peculiar beauty it was subsequently taken to Europe. The fruit was considered poisonous to the human, but was observed to be eaten by lower animals. This fact excited Yankee curiosity and it was tested and adopted as an article of diet in some sections of America. It was not until the beginning of the civil war that its acceptance as an edible food became general. Europe has not up to the present given it general welcome as
Naval Warfare under Climatic Extremes--II
Authors: M. Critchley
Journal: BMJ (1945)

The story of naval clothing can be told in four chapters.At first there was little or no control of what was worn, and pressed men caine aboard clad in their filthy rags, which were re- placed only when eventually disintegrated.This practice natur- ally favoured the spread of louse-borne disease, and especially the febris nautica, or typhus.Next came the period of medical reform at the close of the eighteenth century, when Lind, Blane, and Trotter in turn pleaded for a regulation sea-habit.At length, from the weight of medical pressure, it was made compulsory for all new entries to be stripped, scrubbed-their rags destroyed-and then re-clad in clean apparel supplied by Admiralty "slop ships."Since 1789, thanks to Middleton, the comptroller, special ships were set aside to accommodate new entries during the first few weeks of their Service career.The third chapter concerns the regularization of the quantity, cut, and pattern of the clothing issued-the story of naval uniform, in fact.Two factors brought this about: the institution of continuous service in 1852, and the Grog Committee of 1857, checking the practice of men going ashore and bartering their kit for rum.The Uniform Committee of 1858 followed the precedent of the French marine of two years before, and enacted that every seaman should have so many articles of naval dress, of standard quality and appearance.The Uniform Committee of 1890 reopened the subject and made more recom- mendations along the same lines.This stage of preoccupation with uniform design, badges of rank, buttons, and gold lace lasted until the outbreak of the present war.Since 1939 we have embarked upon the fourth chapter, which deals with the organized science of clothing as a means of pro- tection against climate, flash, bullets, insects, gas, and other nocuous influences.This novel subject of clothing physiology- may be considered in greater detail.
TOC 7th page
Authors: Julie Wang, Scott Sicherer, Anna Nowak-Wegrzyn, New York, Harvey Leo, Bruce Bender, Susan Leung, Zung Vu Tran, Donald Leung, Melinda Rathkopf, Bonnie Whisman, Larry Hagan, Lackland Air, Jonathan Spergel, Nicole Nurse, Paulette Taylor, Anne Parneixspake, East Hanover, Daniel Lee, Graeme Currie
Journal: Journal of Allergy and Clinical Immunology (2004)
Lead in Bone: Implications for Toxicology during Pregnancy and Lactation
Authors: E. K. Silbergeld
Journal: Environmental Health Perspectives (1991)

Advances in understanding the distribution and retention of lead in mineralized tissues are important for two reasons: first, bone lead may be a more accurate dosimeter of integrated absorption associated with chronic exposures, and second, bone lead may be a source of internal exposure to the host organism. Little attention has been paid to this second aspect, the remobilization of lead from bone. Mobilization of lead from bone is likely to occur during periods of altered mineral metabolism; since calciotropic factors determine the uptake and storage of lead in this compartment, changes in calcium-related regulatory factors are likely to affect lead compartmentation. Calcium metabolism changes drastically in humans during pregnancy and lactation; although relatively little is known of lead kinetics during these critical periods, it is likely that bone lead is mobilized and transferred to the more bioavailable compartment of the maternal circulation, with potential toxic effects on the fetus and the mother.
H
Authors: Edwin J. Mikkelsen
Journal: JAMA (1997)

Elizabeth Shepard's<i>H</i>can be read and appreciated on many levels. An epistolary novel, it chronicles the mental condition and progress of a 12-year-old boy. The letters that comprise the novel are written by the principal characters, primarily parents, summer camp personnel, peers, the boy's sister, and his psychiatrist. A fascinating correspondence between the child and his imaginary friend (the friend manifest in a stuffed toy shaped like an H) reveals much about the boy's inner life. The author makes compelling use of the epistolary form. That it is somewhat disjointed actually serves to pique the reader's curiosity. I found myself reading faster and more intently as the novel progressed. <i>H</i>would be a very enjoyable read for anyone who likes psychologically based novels and for those with professional training and experience working with disturbed children. I continually found myself formulating a differential diagnosis and then reformulating it with each
BUENOS AIRES
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Die weiblichen Sexualhormone in ihren Beziehungen zum Genitalzyklus und zum Hypophysenvorderlappen.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dr. Edstrom Is Recovering.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
APPROACH AND READ (FOR THOU CANST READ)
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal