Screening for Lung Cancer With Low-Dose Computed Tomography
Authors: John Brodersen, Asger Dirksen, Jesper Holst Pedersen
Journal: Annals of Internal Medicine (2014)

Letters4 February 2014Screening for Lung Cancer With Low-Dose Computed TomographyJohn Brodersen, MD, GP, PhD, Asger Dirksen, MD, DrMSci, and Jesper Holst Pedersen, MD, DrMSciJohn Brodersen, MD, GP, PhDFrom University of Copenhagen, Copenhagen, Denmark; Gentofte University Hospital, Copenhagen, Denmark; and Rigshospitalet, Copenhagen, Denmark.Search for more papers by this author, Asger Dirksen, MD, DrMSciFrom University of Copenhagen, Copenhagen, Denmark; Gentofte University Hospital, Copenhagen, Denmark; and Rigshospitalet, Copenhagen, Denmark.Search for more papers by this author, and Jesper Holst Pedersen, MD, DrMSciFrom University of Copenhagen, Copenhagen, Denmark; Gentofte University Hospital, Copenhagen, Denmark; and Rigshospitalet, Copenhagen, Denmark.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L14-5003-2 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In their review, Humphrey and colleagues (1) stated that follow-up was insufficient and unequal to evaluate the degree of overdiagnosis in 3 European randomized, controlled trials and that the allocation in the DLCST was unclear. As representatives of that study, we present further clarifying information.We agree that the follow-up of the DLCST (and the 2 other European trials) is currently insufficient to assess the effect on mortality and the level of overdiagnosis. However, for mortality and cancer incidence, the follow-up in the screening and control groups was equal. As our status paper after 5 annual screening ...References1. Humphrey LL, Deffebach M, Pappas M, Baumann C, Artis K, Mitchell JP, et al. Screening for lung cancer with low-dose computed tomography: a systematic review to update the U.S. Preventive Services Task Force recommendation. Ann Intern Med. 2013;159:411-20. [PMID: 23897166] LinkGoogle Scholar2. Saghir Z, Dirksen A, Ashraf H, Bach KS, Brodersen J, Clementsen PF, et al. CT screening for lung cancer brings forward early disease. The randomised Danish Lung Cancer Screening Trial: status after five annual screening rounds with low-dose CT. Thorax. 2012;67:296-301. [PMID: 22286927] CrossrefMedlineGoogle Scholar3. Pedersen JH, Ashraf H, Dirksen A, Bach K, Hansen H, Toennesen P, et al. The Danish randomized lung cancer CT screening trial—overall design and results of the prevalence round. J Thorac Oncol. 2009;4:608-14. [PMID: 19357536] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From University of Copenhagen, Copenhagen, Denmark; Gentofte University Hospital, Copenhagen, Denmark; and Rigshospitalet, Copenhagen, Denmark.Disclosures: None disclosed. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L13-1113. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoScreening for Lung Cancer With Low-Dose Computed Tomography: A Systematic Review to Update the U.S. Preventive Services Task Force Recommendation Linda L. Humphrey , Mark Deffebach , Miranda Pappas , Christina Baumann , Kathryn Artis , Jennifer Priest Mitchell , Bernadette Zakher , Rongwei Fu , and Christopher G. Slatore Screening for Lung Cancer With Low-Dose Computed Tomography Linda L. Humphrey , Mark Deffebach , Miranda Pappas , Bernadette Zakher , and Christopher G. Slatore Screening for Lung Cancer With Low-Dose Computed Tomography John Brodersen , Jakob Fraes Rasmussen , and Bruno Heleno Metrics 4 February 2014Volume 160, Issue 3Page: 211-212KeywordsCancer screeningComputed axial tomographyComputer applicationsComputersConflicts of interestLung and intrathoracic tumorsSoftware toolsThorax ePublished: 4 February 2014 Issue Published: 4 February 2014 CopyrightCopyright © 2014 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...