tbuckley/cabot-search huggingface dataset:
Collecting duct–specific knockout of endothelin-1 causes hypertension and sodium retention
Authors: Dowhan Ahn, Yuqiang Ge, Peter K. Stricklett, Pritmohinder Gill, Deborah Taylor, Alisa K. Hughes, Masashi Yanagisawa, Lance Miller, Raoul D. Nelson, Donald E. Kohan
Journal: Journal of Clinical Investigation (2004)

In vitro studies suggest that collecting duct–derived (CD-derived) endothelin-1 (ET-1) can regulate renal Na reabsorption; however, the physiologic role of CD-derived ET-1 is unknown. Consequently, the physiologic effect of selective disruption of the ET-1 gene in the CD of mice was determined. Mice heterozygous for aquaporin2 promoter Cre recombinase and homozygous for loxP-flanked exon 2 of the ET-1 gene (called CD-specific KO of ET-1 [CD ET-1 KO] mice) were generated. These animals had no CD ET-1 mRNA and had reduced urinary ET-1 excretion. CD ET-1 KO mice on a normal Na diet were hypertensive, while body weight, Na excretion, urinary aldosterone excretion, and plasma renin activity were unchanged. CD ET-1 KO mice on a high-Na diet had worsened hypertension, reduced urinary Na excretion, and excessive weight gain, but showed no differences between aldosterone excretion and plasma renin activity. Amiloride or furosemide reduced BP in CD ET-1 KO mice on a normal or high-Na diet and prevented excessive Na retention in salt-loaded CD ET-1 KO mice. These studies indicate that CD-derived ET-1 is an important physiologic regulator of renal Na excretion and systemic BP.
Pretreatment serum biomarkers and clinical outcome in the phase II trial of zibotentan (endothelin A receptor antagonist) in metastatic CRPC.
Authors: Julia Shelkey, Ajit Kumar Bisen, Kim Leitzel, Suhail M. Ali, Walter P. Carney, Allan Lipton
Journal: Journal of Clinical Oncology (2013)

97 Background: Three angiogenesis-related serum biomarkers [TIMP-1 (tissue inhibitor of metalloproteinase-1), CA IX (carbonic anhydrase 9), and VEGF] and PSA were correlated with outcome in the phase II zibotentan [endothelin A (ET A ) receptor inhibitor] trial in metastatic CRPC. Methods: Pretreatment serum samples were available from 206 of 312 patients enrolled in the multicenter phase II trial evaluating zibotentan in patients with metastatic CRPC and bone metastases who were pain free or mildly symptomatic for pain, with a 1:1:1 randomization to zibotentan 10mg, 15mg, or placebo. The CA IX, TIMP-1, and VEGF ELISAs were from WILEX Inc./ Oncogene Science, Cambridge, MA. Progression-free survival (PFS) and overall survival (OS) were analyzed using the Kaplan-Meier method and Cox modeling. Results: In the final efficacy report, there were no statistical differences in PFS, but a trend for OS improvement was observed in the zibotentan arms compared with placebo: 15 mg (HR 0.76; 80% CI 0.61–0.94; p= 0.103) and 10 mg (HR 0.83; 80% CI 0.67–1.02; p= 0.254) (James et al, BJUI 106L966-973, 2010). In the retrospective serum biomarker analysis (206 patients), there were no apparent differences for PFS with any of the 3 novel biomarkers in the whole population, or within treatment arms. For OS in the whole population, patients with higher serum TIMP (&gt; median) had reduced OS (17.5 mos), compared with patients who had lower serum TIMP-1 (&lt; median) (28.4 mos). Within treatment arms, patients with higher serum CA IX (&gt; median) treated with zibotentan had increased OS in both the 10 mg arm (median 28.4 mos), and the 15 mg arm (median 25.7 mos) compared with those in the placebo arm (median 15.4 mos). In a Cox model, including serum biomarkers and bisphosphonate use, for PFS only PSA was significant (p&lt; 0.0001); for OS only PSA (p&lt; 0.0001) and TIMP-1 (p&lt; 0.002) were significant. Conclusions: Higher pretreatment serum CA IX (a marker of hypoxia) may identify a cohort of metastatic CRPC patients more sensitive to zibotentan treatment, and higher serum TIMP-1 may identify patients at risk for reduced overall survival. These serum biomarkers deserve further study in larger ET A receptor inhibitor trials.
Third International Conference on Cancer Nursing in the 80's
Journal: JNCI Journal of the National Cancer Institute (1983)

Journal Article Third International Conference on Cancer Nursing in the 80's Get access JNCI: Journal of the National Cancer Institute, Volume 71, Issue 6, December 1983, Page 1347, https://doi.org/10.1093/jnci/71.6.1347-b Published: 01 December 1983
Experimental investigations of disorders in higher nervous activity; studies of the interaction of the signalling systems in certain neuropsychiatric diseases, and physiologicallybased therapeutic procedures.
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
INTERNATIONAL CONGRESS OF GYNECOLOGY AND OBSTETRICS.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
INFANT MORTALITY AND THE LAW OF NATURAL SELECTION.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Table of Contents
Authors: B Freidlin, L Mcshane, E Korn, C Allegra, D Aberle, P Ganschow, S Hahn, C Lee, S Millon-Underwood, M Pike, S Reed, A Saftlas, S Scarvalone, A Schwartz, C Slomski, G Yothers, R Zon, B Virnig, T Tuttle, T Shamliyan, R Kane, M.-N Lai, S.-M Wang, P.-C Chen, Y.-Y Chen, J.-D Wang, T Study, G Schnack, C Poulsen, J Myrup, M Wohlfahrt, L Carriers, N Baglietto, J Dowty, D White, A Wagner, E Gomez, A Vriends, N Cartwright, R Barnetson, S Farrington, A Tenesa, H Hampel, D Buchanan, S Arnold, J Young, J Walsh, F Jass, Y Macrae, I Antill, G Winship, J Giles, S Goldblatt, G Parry, B Suthers, M Leggett, M Butz, J Aronson, J Poynter, L Baron, R Le Marchand, S Haile, J Gallinger, J Hopper, A Potter, H De La Chapelle, M Vasen, S Dunlop, M Thibodeau, K Allin, B Nordestgaard, J Zacho, A Tybjaerg-Hansen, S Bojesen, W Chemotherapy, T Köstler, C Brodowicz, F Zielinski Response, P Cardoso, E Bedard, O Winer, E Pagani, L Senkus-Konefka, S Kyriakides, A Costa, T Cufer, K Albain, M Kok, C Holm-Wigerup, M Hauptmann, R Michalides, O Stål, S Linn, G Landberg
Journal: JNCI Journal of the National Cancer Institute (2010)
Cardiac Rehabilitation
Authors: Stan Walch
Journal: JAMA (1980)

<h3>To the Editor.—</h3> I object to the defeatism in Wenger's article on cardiac rehabilitation. The studies she cites to support her views that physical activity after myocardial infarction cannot alter the natural history of the illness are not really relevant. Bassler<sup>1</sup>has estimated that 16,000 km are needed to improve angiograms—an awesome exercise prescription to say the least. Exercise must be performed in units above the threshold of 10 km to be effective (242:322, 1979). However, Wenger cites the work of Nolewajka and associates<sup>2</sup>that involves patients who smoke and exercise below the protective threshold. No one could expect angiograms to improve in seven months under these conditions, and, certainly, Wenger cannot use this study as an index of limitations of exercise therapy. I am using the prescription of "10,000 miles in 6-mile units" with the goal of altering the natural course of the disease. I believe that
A letter from Joseph Lister to Dr David Walsh
Authors: R. R. Landes
Journal: JAMA (1984)

THE GIFT of a previously unpublished letter (Fig 1) written by Joseph Baron Lister to a "Dr Walsh" dated April 12, 1897, prompted us to investigate the identity of the addressee and the circumstances alluded to in its contents. The letter is written on the black-bordered stationery customarily used by Lister following the death of Lady Lister in 1893. His London address, in bold print at the top of the page, is circled. The address of his country house, High Cliff, at Lyme Regis in Dorset on England's south coast is written in, indicating that the letter was written there. At this time Lister had reached the age of 70 years. He had retired from practice but remained extremely active in public affairs. He often sought refuge and rest from his demanding schedule at his beloved High Cliff. This short and courteous but blunt letter was obviously in response to
Interleukin-6 enhances hepatic transferrin uptake and ferritin expression in rats
Authors: M Kobune
Journal: Hepatology (1994)

To explore a mechanism of interleukin (IL)-6–induced hypoferremia in rats, iron metabolism was investigated both in vivo and in vitro. Recombinant IL-6 was intraperitoneally administered to male Wistar rats and the serial change of parameters related to iron metabolism was examined. After administration of IL-6, plasma IL-6 concentration increased rapidly, reached its maximum in 1 hr and thereafter decreased quickly. Plasma IL-6 3 hr after IL-6 injection (50 μg/kg) was 3 units/ml, which is a concentration capable of inducing hepatic 125I–labeled transferrin uptake in vitro using isolated hepatocytes. Plasma iron concentration and transferrin saturation had decreased to approximately one third of the initial level within 3 hr and then recovered. Total iron binding capacity remained unchanged for 6 hr, then began to decrease. Red blood cell count and hemoglobin concentration showed no remarkable changes during this period. By ferrokinetic study with plasma that contained iron 59–labeled transferrin, the plasma iron disappearance half time, calculated from the disappearance curve, was significantly shortened from 55 min to 22 min by IL-6 treatment (p<0.01). The ferritin concentration in the liver was increased significantly after the administration of IL-6 (p<0.001), but transiently decreased in the spleen. The plasma ferritin showed a gradual increase during the 6-hr period after IL-6 injection. The uptake of 125I-labeled diferric transferrin by isolated hepatocytes was increased by IL-6 treatment and this increment was inhibited by addition of 100-fold excess unlabeled transferrin. On the other hand, no significant increment of 125I-labeled differic transferrin uptake was observed in Kupffer cells. These results confirmed that in rats, IL-6 produced a rapid increase of hepatic uptake of serum iron by means of transferrin receptor and resulted in hypoferremia. (HEPATOLOGY 1994;19:1468–1475.)
Failure of pulse high‐dose dexamethasone in chronic idiopathic immune thrombocytopenia
Authors: M. Warner, P. Wasi, S. Couban, C. Hayward, T. Warkentin, J.G. Kelton
Journal: American Journal of Hematology (1997)

Idiopathic thrombocytopenic purpura (ITP) is a disorder characterized by increased platelet destruction in the setting of normal megakaryopoiesis. Approximately 20% of patients with ITP are refractory to corticosteroids and splenectomy. Recently, pulse high-dose dexamethasone was reported to be effective in the treatment of chronic ITP in adult patients. We treated 9 patients with severe chronic ITP with monthly high-dose dexamethasone. None of the 9 patients responded with a sustained increase in platelet count. Five of these patients were unable to tolerate the regimen. The failure of high-dose dexamethasone in our hands contrasts with the good results of an earlier publication and suggests that there could be a subset of responders who will require better identification. Am. J. Hematol. 54:267–270, 1997. © 1997 Wiley-Liss, Inc.
Some Observations on the Interaction of Zinc, Copper, and Iron Metabolism in Lead and Cadmium Toxicity
Authors: Harold G. Petering
Journal: Environmental Health Perspectives (1978)

A brief review of the literature indicates that nutritional deficiencies have been shown to increase the absorption and toxicity of orally ingested lead and cadmium. Results from recent studies indicates that low level oral ingestion of cadmium and lead perturbs the metabolism of zinc, copper, and iron and that these changes may be the earliest manifestation of the toxicity of lead and cadmium. The significance of these findings reveals itself in two ways: namely, that toxicologic investigations of lead and cadmium, whether experimental or clinical, must be based on a definitive consideration of the nutritional status of animals or people, and, secondly, that the preventive role of nutrition, especially that of trace metal intakes, must be taken seriously when establishing measures for reducing, eliminating, or combatting the toxic effects of widespread exposure to lead and cadmium in humans.
Whither informed consent?
Authors: D. H. Mills
Journal: JAMA (1974)

Moderation is necessary in deciding how much to tell patients to ensure valid consents for surgical or other procedures. Since the courts will not tell physicians, except by hindsight, the extent of legally required disclosures, it is necessary to develop a reasonable approach—one that provides patients with sufficient basic information to exercise their right of refusal while, at the same time, offering physicians reasonable legal protection. The groundwork for such a plan has been formulated. (<i>JAMA</i>229:305-310, 1974)
Efficacy of Haemophilus b polysaccharide vaccine: an enigma
Authors: E. A. Mortimer
Journal: JAMA (1988)

This issue of<i>JAMA</i>contains reports of three retrospective studies<sup>1-3</sup>of the efficacy of<i>Haemophilus</i>b polysaccharide vaccine. The point estimates of protection against invasive disease due to<i>Haemophilus influenzae</i>type b (Hib) are disparate: results of two of these studies<sup>1,2</sup>indicate efficacy (88% and 45%, respectively), but the third study<sup>3</sup>found an enhanced risk of invasive Hib disease in vaccinated children ( - 55% efficacy). An explanation for these differing results is not available. <i>Haemophilus</i>b polysaccharide vaccine, first licensed in the United States in 1985, comprises the capsular polysaccharide from Hib, natural antibodies to which correlate well with clinical immunity to invasive Hib disease. The vaccine's efficacy was shown to be 90% in Finnish children<sup>4</sup>and the demonstration of antibody production in US children was considered to be a surrogate for clinical protection.<sup>5</sup>However, in common with other polysaccharide vaccines, efficacy was neither shown nor
International Symposium on Nutrition, Growth, and Cancer
Journal: JNCI Journal of the National Cancer Institute (1986)

Journal Article International Symposium on Nutrition, Growth, and Cancer Get access JNCI: Journal of the National Cancer Institute, Volume 77, Issue 5, November 1986, Page 1174, https://doi.org/10.1093/jnci/77.5.1174-a Published: 01 November 1986
Sulpice Antoine Fauvel (1813-1884) French epidemiologist
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Epidemiologic Evidence for an Association between Gasoline and Kidney Cancer
Authors: Philip E. Enterline, John Viren
Journal: Environmental Health Perspectives (1985)

A recent animal experiment suggests that gasoline exposure may be a cause of human kidney cancer. This is a literature review to see whether there is any epidemiologic support for these animal findings. Trends and geographic patterns in gasoline consumption and kidney cancer mortality are moderately supportive of a relationship, although this cannot be considered important evidence for a causal relationship. Most other ecological correlations are not supportive of a relationship. Eleven oil refinery populations and one population of petroleum products distribution workers have been studied. These studies taken as a group do not appear to support the notion of a relationship between gasoline exposure and kidney cancer. However, most were not designed or analyzed with this hypothesis in mind. An examination of these data which attempts to consider the ages of the populations studied provides some evidence of a small kidney cancer excess among older workers or among workers exposed for long periods. Because of the importance of gasoline and the potential for exposure by the public further study of exposed populations is needed.
<i>Circulation</i> : Clinical Summaries
Journal: Circulation (2016)

Composition, and not Efflux Capacity, Reflects Differential Modulation of Reverse Cholesterol Transport by Saturated and Monounsaturated Fat DietsReverse cholesterol transport (RCT) is the process by which cholesterol from peripheral cells is effluxed onto circulating high-density lipoprotein (HDL) particles to be returned to the liver for excretion.Promotion of RCT is thought to reduce cardiovascular disease risk; however, raising high-density lipoprotein cholesterol (HDL-C) levels by using cholesteryl ester transfer protein inhibitors failed to have clinical benefit.HDL particles carry a large cargo of proteins, in particular, immune modulatory proteins that likely alter the atheroprotective functions of HDL.This study demonstrates that saturated fatty acid (SFA)-induced obesity increased HDL-C and macrophage-to-plasma RCT in vivo; however, liver-to-feces RCT was impaired coupled with increased hepatic inflammation and downregulation of hepatic transporter expression in comparison with lean controls.Replacement of SFA with monounsaturated fatty acid within obesogenic diets increased all steps of macrophage-to-feces RCT with lower levels of hepatic inflammation evident in comparison with SFA-highfat diet.The proteome of HDL particles was enriched with proinflammatory hepatic-derived acute-phase proteins after SFA-high-fat diet in comparison with monounsaturated fatty acid-high-fat diet reflecting differential modulation of liver-to-feces RCT by SFA-and monounsaturated fatty acid-high-fat diets.Recent meta-analysis has suggested that high-SFA intake is not associated with cardiovascular disease.Furthermore, high carbohydrate consumption lowers HDL-C, whereas high fat consumption raises HDL-C.Although dietary replacement of carbohydrate for fat may normalize lipid profiles in obesity, our study warrants caution over the fat quality used in such an approach.Dietary replacement of carbohydrate with SFA may increase levels of proinflammatory HDL particles and increase cardiovascular disease risk despite elevating HDL-C.By contrast, dietary replacement of carbohydrate for monounsaturated fatty acid may raise HDL-C, preserve the anti-inflammatory proteomic composition of HDL particles, and increase RCT.See p 1838.
New York Science Week (June 23–29, 1978): Scientific Basis for Public Health Control of Environmental Hazards
Journal: JNCI Journal of the National Cancer Institute (1977)

New York Science Week (June 23–29, 1978): Scientific Basis for Public Health Control of Environmental Hazards Get access JNCI: Journal of the National Cancer Institute, Volume 59, Issue 6, December 1977, Page 1755, https://doi.org/10.1093/jnci/59.6.1755-a Published: 01 December 1977