tbuckley/cabot-search huggingface dataset:
Management of shoulder-hand syndrome
Authors: E. W. Johnson
Journal: JAMA (1966)

Although much has been written about the diagnosis. and management of shoulder-hand syndrome, diverse opinions remain with respect to the optimal treatment. For purposes of definition, the shoulder-hand syndrome should be considered an aspect of the more general term—reflex sympathetic dystrophy. There are many names which have been used for this clinical condition, including reflex physiopathia, reflex neurovascular dystrophy, posttraumatic fibrosis, Sudeck's atrophy, causalgia, atrophic hand, and postinfarctional sclerodactylia, among many others. Our purpose in reviewing our experience with the shoulder-hand syndrome over the last ten years is to reemphasize the successful results of physical treatment, which Silas Weir Mitchell recommended in his description of causalgia in 1864. <h3>Review of the Literature</h3> Mitchell<sup>1</sup>described causalgia of the hands and feet resulting from gun-shot wounds in the Civil War. The syndrome included burning pain and a swollen, shiny extremity. He noted that many soldiers filled their boots with water for
Blue rubber bleb naevus syndrome: an unusual cause of urethral bleeding
Authors: J.R. Wilson, M.J. Weston, P. Singh, I. Eardley
Journal: British Journal of Dermatology (2000)

Journal Article Blue rubber bleb naevus syndrome: an unusual cause of urethral bleeding Get access J.R. Wilson, J.R. Wilson Pyrah Department of Urology and Search for other works by this author on: Oxford Academic Google Scholar M.J. Weston, M.J. Weston Department of Radiology, St James’ University Hospital, Leeds LS9 7TF, U.K. Correspondence: J.R.Wilson, Bradford Royal Infirmary, Duckworth Lane, Bradford BD10 0ET, U.K. E‐mail: wilson_russ@yahoo.co.uk Search for other works by this author on: Oxford Academic Google Scholar P. Singh, P. Singh Pyrah Department of Urology and Search for other works by this author on: Oxford Academic Google Scholar I. Eardley I. Eardley Pyrah Department of Urology and Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 143, Issue 3, 1 September 2000, Pages 677–678, https://doi.org/10.1111/j.1365-2133.2000.03751.x Published: 01 September 2000
Reference Committees
Journal: JAMA (1978)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Wrong Structural Formula
Journal: JAMA (1975)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Cover
Authors: Frederick Butzen
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Gene Manipulation
Authors: Howard L. Bleich, Emily S. Boro, Stanley N. Cohen
Journal: New England Journal of Medicine (1976)

Ordinarily, the characteristics of biologic species are gradually changed by the slow process of evolution. During this process, the genetic integrity of evolving species is preserved by natural barriers that prevent the merging of hereditary characteristics from very dissimilar organisms. The barriers that interfere with the exchange of genetic material, or DNA, between unrelated species are poorly understood, but they appear to be of fundamental biologic importance.Recently, it has become possible to breach these barriers by experimental manipulation of genes and cells in ways that permit transfer of genes to a totally unrelated host1 2 3 4 5 6 7 8; hereditary material from virtually . . .
Lack of association between venous thrombosis and subsequent malignancy in a retrospective cohort study in young patients
Authors: Maricel Subirà, José Mateo, Juan C. Souto, Albert Altés, Jordi Fontcuberta
Journal: American Journal of Hematology (1999)

Since the publication of Trousseau in 1865, several studies have documented an increased incidence of cancer in patients with deep venous thrombosis (DVT) especially those with idiopathic or recurrent DVT, but in young patients this association is not clear and is therefore a subject of controversy. We performed a retrospective study in a consecutive cohort of 40 young patients (age <40 years) with a DVT and without a known cancer. All patients were diagnosed in our hospital during the period of 1988–1992. At the time of diagnosis, a routine examination to detect the presence of malignant disease was made. For the follow-up, all patients included in the study were asked to return to our unit and were interviewed for symptoms that could suggest a malignant disease. The mean follow-up was five years (from three to eight years). Twenty-four patients had DVT in the lower limbs and three in the upper extremities, nine had pulmonary embolism (six of them with DVT) and four had DVT in other sites. Sixteen patients (40%) had secondary DVT due to nonbiological causes, abnormalities in hemostasis were found in 14 patients (35%), and biological or environmental triggering factors were not identified in 10 patients (25%). Malignancies were not detected at diagnosis and in the follow-up. In our experience, venous-thrombotic patients under the age of 40 have a low incidence of subsequent cancer. Further studies should be performed to confirm this observation and to ascertain whether extensive screening for cancer is a cost-effective approach. Am. J. Hematol. 60:181–184, 1999. © 1999 Wiley-Liss, Inc.
Infants, children test positive for cocaine after exposure to second-hand crack smoke
Authors: T. Randall
Journal: JAMA (1992)

COCAINE can show up in the most unexpected places. Recently, at Children's Hospital of Michigan in Detroit, the emergency department found cocaine metabolite in the urine of more than 5% of the toddlers and children treated there for routine pediatric complaints (<i>Am J Dis Child</i>. 1991;145:1430-1432). The most likely route of exposure, the researchers suggest, is second-hand smoke inhaled when adult caretakers use freebase or crack cocaine. The physiological and behavioral effects of chronic environmental exposure to cocaine in children are not well established. There have been several cases reported in the scientific literature of cocaine toxicity in children exposed to crack smoke. Two had transient neurological symptoms such as drowsiness and unsteady gait, and three had seizures that laboratory tests could not explain (<i>Am J Dis Child</i>. 1989;143:25-27 and 1990;144:743-744). Some studies in adult animals have suggested a "kindling" phenomenon, in which the central nervous system becomes more sensitive
Impact of Treatment Intensification According to Patient Prognosis: A Pooled Analysis of 3 Randomized Phase III Trials
Authors: Francesca Gay, Mattia D'Agostino, Roman Hajek, Sara Bringhen, Concetta Conticello, Gianluca Gaidano, Vittorio Montefusco, Sara Pezzatti, Marco Salvini, Tommaso Caravita, Anna Maria Cafro, Michele Cavo, Marina Ruggeri, Fortunato Morabito, Roberto Mina, Luca Baldini, Giulia Benevolo, Tommasina Guglielmelli, Annalisa Bernardini, Roberto Foà, Francesca Patriarca, Massimo Offidani, Roberto Ria, Dina Ben Yehuda, Maria Teresa Petrucci, Andrew Spencer, Antonio Palumbo, Mario Boccadoro
Journal: Blood (2016)
P91 EFFECT OF TOLL-LIKE RECEPTOR 7 AND 9 TARGETED THERAPY TO PREVENT THE DEVELOPMENT OF HEPATOCELLULAR CARCINOMA
Authors: F. Mohamed, R. Al-Jehani, S. Minogue, F. Andreola, A. Winstanley, S. Olde Damink, M. Malagó, N. Davies, T.V. Loung, A. Dhillon, R. Mookerjee, D. Dhar, R. Jalan
Journal: Journal of Hepatology (2014)
The combination of EpCAM-positive circulating tumor cells and serum AFP/AFP-L3/DCP predicts outcome after curative resection of hepatocellular carcinoma
Authors: Johann von Felden, Martin Schoenlein, Berit Behrends, Christian Casar, Thorben Fruendt, Carolin Jung, Jenny Krause, Harald Ittrich, Munif Haddad, Thomas Renne, Asmus Heumann, Jun Li, Lutz Fischer, Ansgar Lohse, Klaus Pantel, Sabine Riethdorf, Henning Wege, Kornelius Schulze
Journal: Journal of Hepatology (2020)
Single-institution experience with neoadjuvant chemotherapy for metaplastic breast cancer (MBC).
Authors: Anna Kaminsky
Journal: Journal of Clinical Oncology (2012)

140 Background: Metaplastic breast carcinoma (MBC) is a rare subtype that accounts for &lt;1% of all breast carcinomas. MBC is frequently triple-negative and neoadjuvant chemotherapy (NAC) is often used in triple-negative breast cancer (TNBC). The objective of this analysis is to ascertain response rates of MBC to NAC as compared to non-metaplastic TNBC. Methods: We searched the Magee Women’s Cancer Center of UPMC IRB-approved neo-adjuvant treatment database which contains outcome data on 594 patients treated from 2004-2010. 116 patients with triple negative breast cancer (ER /PR negative or ER /PR weakly positive [H score of 10 or less] and HER2 negative or indeterminate [HER2 1+ or 2+ without amplification by FISH]), were identified. Nine of these TNBCs had metaplastic subtype and two groups were analyzed: metaplastic breast carcinoma (MBC) (N= 9) and non-metaplastic breast carcinoma (NMBC) (N = 107). Tumor volume reduction (TVR), pathologic complete response (pCR), recurrence and mortality were compared in both groups. Results: Average follow-up in MBC group was 43 months and no patients were lost to follow-up. Average tumor size on presentation in MBC group was 4.47 cm while in NMBC group it was 3.33 cm. pCR was noted in 0/9 MBC and 43/107 NMBC cases (p = 0.0253). 6/9 patients had mastectomy, 2/9 had breast conserving surgery (BCS) and 1/9 patients did not have a surgery yet. Average TVR was 28% in MBC cases compared to 74% in NMBCs when cases with pCR were included (p = 0.0001) and 56% when cases with pCR were excluded (p = 0.0202). Follow up on 9 MBC cases revealed 1 recurrence and subsequent death (11%). Follow-up on 64 NMBC patients who failed to achieve pCR revealed 22 recurrences (34%) and 18 of them subsequently died (28%). Follow-up on 43 NMBC cases that achieved pCR revealed 3 recurrences (7%) and 1 death (2%). Conclusions: MBC was characterized by larger size at baseline as compared to NMBC. There were no pCR’s seen in MBC, but some MBC did achieve response that allowed for breast conservation. Although the average tumor volume reduction was significantly less in MBC compared to NMBC, the NMBC that failed to achieve pCR fared much worse than MBC who did not achieve pCR. Therefore, the triple-negative paradox is likely not applicable to MBC.
Response to: ‘Correspondence on ‘Risk of systemic lupus erythematosus after immune thrombocytopenia and autoimmune haemolytic anaemia: a nationwide French study’’ by Maquetet al
Authors: Xiao-Huan Chen, James Cheng Chung Wei, Han-You Mo, Hsin-Hua Chen
Journal: Annals of the Rheumatic Diseases (2020)
Effects of endurance training on glucose tolerance and plasma lipid levels in older men and women
Authors: D. R. Seals
Journal: JAMA (1984)

Eleven healthy men and women (63 ±1 years) participated in a 12-month endurance-training program to determine the effects of low-intensity and high-intensity training on glucose tolerance and plasma lipids in older persons. Plasma glucose, insulin, and C-peptide concentrations were measured for three hours after ingestion of 100 g of glucose and the total areas under the respective curves were calculated. Total plasma lipids and lipoprotein concentrations were determined during fasting. Maximal oxygen uptake increased 12% during six months of low-intensity training; a further 18% increase occurred during an additional six months of high-intensity training. Glucose tolerance, which was normal initially, was not significantly changed after training. However, the total area for insulin was 8% lower after low-intensity training, and 23% lower after high-intensity training, compared with before training. C-peptide concentrations were similarly reduced. Plasma lipid and lipoprotein concentrations were unchanged after low-intensity training, but high-intensity training resulted in an increase in high-density lipoprotein cholesterol and a reduction in triglycerides. These results demonstrate that older persons respond to prolonged, high-intensity endurance training with an increase in sensitivity to insulin and a favorable alteration in their plasma lipoprotein-lipid profile. (<i>JAMA</i>1984;252:645-649)
Developmental Effects of Endocrine-Disrupting Chemicals in Wildlife and Humans
Authors: Theo Colborn, Frederick S. vom Saal, Ana M. Soto
Journal: Environmental Health Perspectives (1993)

Large numbers and large quantities of endocrine-disrupting chemicals have been released into the environment since World War II. Many of these chemicals can disturb development of the endocrine system and of the organs that respond to endocrine signals in organisms indirectly exposed during prenatal and/or early postnatal life; effects of exposure during development are permanent and irreversible. The risk to the developing organism can also stem from direct exposure of the offspring after birth or hatching. In addition, transgenerational exposure can result from the exposure of the mother to a chemical at any time throughout her life before producing offspring due to persistence of endocrine-disrupting chemicals in body fat, which is mobilized during egg laying or pregnancy and lactation. Mechanisms underlying the disruption of the development of vital systems, such as the endocrine, reproductive, and immune systems, are discussed with reference to wildlife, laboratory animals, and humans.
PLoS Medicine Issue Image | Vol. 3(3) March 2006
Journal: PLoS Medicine (2006)

How does an artist respond to a body made unfamiliar and out of control? I started Hair Stories after my breast cancer diagnosis. From the chaotic realm of illness and uncertainty, I produced a post-chemotherapy series of self-portraits through weekly photographs. Using the ordered structure and language of minimalism and scientific documentation, I challenged the disorder I confronted. My photographs examine the steady resumption of natural processes and the surprise of new hair growth. In the accompanying flipbook and voiceover, hair images (sequential, impersonal, and almost anonymous) are combined and contrasted with stories (vivid, personal, and anachronistic) that explore hair in the context of my personal history. Hair Stories has been exhibited at the DeCordova Museum in Lincoln, Massachusetts; The Arts Center of the Capital Region in Troy, New York; Wesleyan University; Simmons College; Portland State University; and University of the Arts in Philadelphia. Karin Stack's drawings, prints, and photographs have been exhibited throughout the country. She earned a BA with honors from Wesleyan University and an MFA from Colorado State University. Awards include a Massachusetts Cultural Council grant and fellowships from the Ragdale and Vermont Studio Center. She has also taught at Amherst College and Wellesley College. Hair Stories © 2002 Karin Stack (http://www.karinstack.com) Image Credit: Karin Stack
The Environment
Authors: Donna Barnako
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Exchange
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Patient-reported outcomes from MA.17R: A randomized trial of extending adjuvant letrozole for 5 years after completing an initial 5 years of aromatase inhibitor therapy alone or preceded by tamoxifen in postmenopausal women with early-stage breast cancer.
Authors: Julie Lemieux, Paul E. Goss, Wendy R. Parulekar, James N. Ingle, Kathleen I. Pritchard, Nicholas J. Robert, Hyman Muss, Julie Gralow, Kathrin Strasser-Weippl, Michael Donald Brundage, Kate Whelan, Dongsheng Tu, Timothy Joseph Whelan
Journal: Journal of Clinical Oncology (2016)

LBA506 The full, final text of this abstract will be available at abstracts.asco.org at 7:30 AM (EDT) on Sunday, June 5, 2016, and in the Annual Meeting Proceedings online supplement to the June 20, 2016, issue of the Journal of Clinical Oncology. Onsite at the Meeting, this abstract will be printed in the Monday edition of ASCO Daily News.
Induction of Dominant Mutations That Cause Skeletal Malformations in Mice
Authors: Paul B. Selby
Journal: Environmental Health Perspectives (1978)

A new approach for estimating genetic risk to humans from radiation is based upon an analysis of the frequency of induction of dominant mutations that cause skeletal abnormalities in mice. The main goal of this work is to improve estimates of the effect that an increase in the mutation frequency would have upon the incidence of serious genetic diseases in humans. The data obtained relate to dominant and irregularly inherited conditions in humans, which together constitute the great majority of human genetic diseases. The skeletal method could be used in chemical mutagenesis research in order to make a much more accurate risk-benefit analysis. A more likely application, however, is to provide a relatively quick and easy mammalian testing procedure for identifying mutagens. Dominant mutations at an unknown, but probably large, number of genetic loci could be detected. The relatively quick and easy procedure, which is described, has not yet been tested.