tbuckley/cabot-search huggingface dataset:
Medical exorcism required as revitalized revenant of tuberculosis haunts and harries the land
Authors: M. F. Goldsmith
Journal: JAMA (1992)

THE AMERICAN Lung Association (ALA) has got the "TB Blues." At a press conference held during its annual meeting in Miami Beach, Fla, a recording of this old lament sung by Jimmie Rodgers set the tone for a nationwide call to arms against the resurgent threat of tuberculosis. From the 1960s until a few years ago, the belief that this disease was nearly gone from the United States allowed the ALA to expand its activities into areas far beyond the scope of the National Association for the Study and Prevention of Tuberculosis, founded in 1904, the group from which it developed. Now, says new ALA president Lee B. Reichman, MD, "the association is working overtime to keep the American public in the know about TB, until this dreaded, deadly disease is eradicated in this country once and for all." Reichman says the TB situation will soon be out of control
Handbuch der normalen und pathologischen Physiologie mit Berücksichtigung der experimentellen Pharmakologie.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Development of a proposed biosimilar product based on the demonstration of physicochemical, pharmacologic and clinical similarity to filgrastim.
Authors: Stephen Brokx, Kalpna Desai, Sanyukta Kher, Tina Catalano, Devanshi Maharaja, Louise Scrocchi, Jason Dowd
Journal: Journal of Clinical Oncology (2015)

e13528 Background: Biosimilar development involves extensive analytical testing to ensure comparability to the reference medicinal product to support the demonstration of similarity in terms of clinical efficacy and safety. We report physicochemical, functional and clinical characterization of the proposed biosimilar, Apo-Filgrastim to the reference product Neupogen. Methods: A variety of orthogonal methods was applied to analyze primary and higher order structures, purity, and biological activity. Methods included spectroscopic and chromatographic methods and a cell based potency assay. An extensive clinical program was also conducted. Three single-dose Phase I studies were performed with Apo-Filgrastim and Neupogen in healthy volunteers over a dose range of ~ 1- 5 µg/kg. A multiple-dose study at 5 µg/kg/day was also performed. Absolute Neutrophil Count (ANC) was the primary PD endpoint used as surrogate marker for efficacy. CD34+ count was assessed as a secondary efficacy measure under multiple dose conditions. A Phase III, non-comparative study was conducted in 120 breast cancer patients to assess efficacy, safety and immunogenicity of Apo-Filgrastim. Results: Apo-Filgrastim has the same primary and higher order structure as Neupogen as seen by peptide mapping and 2D-NMR. Purity of Apo-Filgrastim averaged 99.8%, vs. 99.7% for Neupogen, using RP-HPLC. Potency of Apo-Filgrastim was equivalent to Neupogen as demonstrated in a cell-based bioassay. Clinical results demonstrated PK similarity between Apo-Filgrastim and Neupogen, such that for all studies, the 90% CI of the primary PK endpoint parameters AUC and Cmax was contained within a pre-defined acceptance limit of 80-125%. PD similarity was also demonstrated with the 95% CI of primary ANC PD endpoint parameters AUC and Cmax falling within pre-defined limits of 80-125%. Clinical efficacy and patient safety data for Apo-Filgrastim were consistent with those reported for Neupogen. Conclusions: In vitro analysis demonstrated finger-print-like similarity, and the clinical program demonstrated that there are no clinically meaningful differences between Apo-Filgrastim and Neupogen.
Incorrect Number in: Postmenopausal Hormone Therapy and Risk of Cardiovascular Disease by Age and Years Since Menopause
Authors: Todd Hulgan, Jeffrey Klausner, San Francisco
Journal: JAMA (2008)

To the Editor: The Commentary by Dr Jaffe and colleagues 1 addressed the reemerging human immunodeficiency virus (HIV) epidemic among men who have sex with men in the United States.The authors describe substance abuse, particularly methamphetamines and alcohol, as one of the factors that contribute to unsafe sexual behaviors.Important substances of abuse that were not mentioned in the Commentary are phosphodiesterase type-5 inhibitors: sildenafil, vardenafil, and tadalafil.Phosphodiesterase type-5 inhibitors are indicated for the treatment of impotence but can enhance erectile function in the absence of clinical impotence and are often used in combination with other recreational drugs. 2 In multiple surveys of US men who have sex with men, current or recent sildenafil use (with and without concomitant illicit drug use) was reported by 6% to 31% of respondents and was associated with increased rates of high-risk behaviors (eg, unprotected anal intercourse, HIV serodiscordant partners, and methamphetamine use) and diagnosis of sexually transmitted infections, including early syphilis and HIV. 3 More recent data have corroborated those findings. 4Discussion of phosphodiesterase type-5 inhibitor abuse in the context of the US HIV epidemic is warranted because at the point of prescribing a phosphodiesterase type-5 inhibitor, clinicians can initiate risk reduction interventions, including sexually transmitted infection and HIV screening. 5In addition, we believe that federal agencies should carefully monitor the use and marketing of phosphodiesterase type-5 inhibitors and work together to limit the effects of these drugs on the reemerging HIV epidemic and other sexually transmitted infections.
Patterns of care related to age of breast cancer patients
Authors: S. Greenfield
Journal: JAMA (1987)

We performed a chart review study to determine whether physicians provided less vigorous treatment for elderly patients with breast cancer than for younger patients. Seven hospitals, varying with respect to size, medical school affiliation, and patient socioeconomic status participated in this study. Patterns of breast cancer care were compared with a set of branching logic standards in the form of a criteria map. A chart-based comorbidity index was developed to control for the influence of coexisting diseases on cancer management. Logistic regression analysis of 374 breast cancer cases revealed that both patient age and comorbidity status significantly and independently affected treatment. Among stage I and II patients with no or very mild comorbid disease, 96% of those aged 50 to 69 years received appropriate surgery vs 83% of patients aged 70 years and older. We conclude that physicians may manage patients with this highly treatable disease according to chronologic age without regard for physiological condition and that this age bias may result in a less favorable prognosis than could be achieved using currently recommended therapy. (<i>JAMA</i>1987;257:2766-2770)
Anosmia After Craniocerebral Trauma
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diagnostic Laparoscopy
Authors: U Weickert, R Jakobs, J F Riemann
Journal: Endoscopy (2005)

Each diagnostic procedure needs to be viewed in the context of all the other available diagnostic tools, and therefore has to be reevaluated periodically. This is also true of diagnostic laparoscopy, whether performed by gastroenterologists in patients under sedoanalgesia or by surgeons in patients under general anesthesia. Publications during the previous year have shed light on many important issues. Despite its greater expense, fluorescence laparoscopy may have advantages over white-light laparoscopy in the diagnosis of small tumor seeding. The unchanged superiority of laparoscopy over other imaging modalities for detecting small superficial liver metastases and peritoneal seeding has been clearly demonstrated. Whether cytological investigation of peritoneal washing can add relevant information to laparoscopy remains a matter of debate. Diagnostic laparoscopy before surgery has proved to be effective in many fields, including traumatology. The use of diagnostic laparoscopy in certain clinical circumstances, such as the early postoperative period after major cardiac surgery using extracorporeal circulation, appears promising. A transgastric approach to the peritoneal cavity for diagnostic and therapeutic purposes, the feasibility of which has been demonstrated in a porcine model, is an exciting innovation with as yet unforeseeable implications.
Personal.—
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Inverted Logic—TV Style
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Typhoid hepatitis
Authors: S. Ramachandran
Journal: JAMA (1974)

Hepatomegaly occurred in 27% of patients having enteric fever. Its incidence in typhoid fever (29%) was slightly higher than in paratyphoid fever (23.5%). Jaundice was noted in less than a third of the patients with hepatic enlargement. The pathological basis for the hepatic manifestations was a "nonspecific reactive hepatitis." Histological changes in the liver were also observed in patients without hepatic enlargement. Whereas hepatic manifestations appeared to be of no great clinical significance in the majority of cases, they were the dominant feature in a small but important group. These patients had the clinical features seen in other hepatic infections, like viral hepatitis and hepatic amebiasis. Hepatitis should be listed among the various presentations and complications which can occur in typhoid and paratyphoid fever. (<i>JAMA</i>230:236-240, 1974)
Applying brakes to the runaway American health care system. A proposed agenda
Authors: N. E. Davies
Journal: JAMA (1990)

The American health care system, and especially its cost, is out of control, inhibiting access to care for many, lessening quality of care for some, and creating an almost palpable angst among physicians and others concerned with this enormous national problem. Increased health care rationing in the next decade is inevitable, yet it must not be done with quick fixes, short-term solutions, and patchwork reform of our present system. That would create worse problems for health care in the 21st century and is clearly unacceptable. We recommend that President Bush appoint a blue-ribbon commission to study our present system in depth, then offer alternative solutions for its many problems. He should look closely at at least the following nine issues: controlling medical technology, instituting a resource-based relative value system for physician reimbursement, establishing an ongoing national medical ethics commission, instituting national malpractice reform, implementing universal medical coverage with Medicare/ Medicaid reform, establishing a national health services research and planning institute, reducing the nation's health care facilities, reducing physician supply, and improving health promotion/disease prevention education. (<i>JAMA</i>. 1990;263:73-76)
Arylamines Suppress Their Own Activation and That of Nitroarenes in V79 Chinese Hamster Cells by Competing for Acetyltransferases
Authors: Franz Kiefer, Olga Cumpelik, Rashmeet Reen, Johannes Doehmer, Friedrich J. Wiebel
Journal: Environmental Health Perspectives (1994)

The effect of 2-aminofluorene (2-AF) on the toxicity of 2-aminoanthracene (2-AA) and 1,6-dinitropyrene (1,6-DNP) was studied in N-acetyltransferase- proficient V79-NHr1A2 cells genetically engineered for the expression of cytochrome P4501A2, and in wild-type V79-NH cells.2-AA inhibited the growth of V79-NHrlA2 cells and induced the formation of micronuclei at concentrations of 0.1 to 1.0 pM, but was virtually without toxic effects at a concentration of 10 pM.Addition of 2-AF protected against the cytotoxic and genotoxic effects elicited by low concentrations of 2-AA.Half-maximum protection was observed at 0.2 to 0.5 pM 2-AF.The arylamine also prevented the cytotoxicity caused by 1,6-DNP in V79-NH cells and completely suppressed the formation of 1-acetylamino-6-nitropyrene from 1,6-DNP in these cells.The results indicate that arylamines and related N-hydroxyaryl- amines are substrates for the same acetyltransferase in V79-NH cells.In consequence, arylamines are capable of suppressing the activation of their proximate cytotoxic and genotoxic products in these cells and, presumably, in vivo.-
ANOMALIES OF THE DUCT OF MÜLLER AS THE CAUSE OF ECTOPIC PREGNANCY.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Validity of Reported Genetic Risk Factors for Acute Coronary Syndrome
Authors: Jeanette J. McCarthy, Eric J. Topol
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Chemical Irrigation of Wounds Inoculated with Cancer Cells
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bee Sting Dysphagia
Authors: Dhiren Shah
Journal: Annals of Internal Medicine (1999)

Letters1 June 1999Bee Sting DysphagiaDhiren Shah, MD and Tat-Kin Tsang, MDDhiren Shah, MDNorthwestern University Medical School; Evanston, IL 60201 (Shah)Northwestern University Medical School; Evanston, IL 60201 (Tsang)Search for more papers by this author and Tat-Kin Tsang, MDNorthwestern University Medical School; Evanston, IL 60201 (Shah)Northwestern University Medical School; Evanston, IL 60201 (Tsang)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-130-11-199906010-00011 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We thank Drs. DeGrandi-Hoffman and Hoffman for pointing out the differences between a honeybee and a yellowjacket. Given this explanation, this patient probably had an allergic reaction to a yellowjacket. However, acute to subacute treatment in the emergency department would not have changed our management.Dr. Levine recommends subcutaneous administration of epinephrine followed by intramuscular administration of diphenhydramine. It is agreed that for acute anaphylaxis, subcutaneous epinephrine and antihistamines, such as diphenhydramine, should be immediately administered. However, we did not administer these treatments because our patient had no evidence of hypotension, shortness of breath, pruritis, or uticaria and ... Author, Article, and Disclosure InformationAuthors: Dhiren Shah, MD; Tat-Kin Tsang, MDAffiliations: Northwestern University Medical School; Evanston, IL 60201 (Shah)Northwestern University Medical School; Evanston, IL 60201 (Tsang) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoBee Sting Dysphagia Dhiren Shah and Tat-Kin Tsang Functional Somatic Syndromes Arthur J. Barsky and Jonathan F. Borus Recent Advances in Varicella-Zoster Virus Infection Moderator: Jeffrey I. Cohen , Discussants: Philip A. Brunell , Stephen E. Straus , and Philip R. Krause Metrics 1 June 1999Volume 130, Issue 11Page: 943KeywordsAnaphylaxisDysphagiaDyspneaEmergency departmentEpinephrineHypotensionPatientsPruritusSigns and symptomsSteroids ePublished: 15 August 2000 Issue Published: 1 June 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...