tbuckley/cabot-search huggingface dataset:
Promoting sexual health.
Authors: A. Palfreeman, T. Sharp, S. Thornton, F. Boag
Journal: BMJ (1992)

gastric motility as observed in states of reduced dietary intake such as anorexia nervosa.' Un- fortunately, Chua and colleagues do not report dietary data or body mass indices.All functional diseases must ultimately be explicable in terms of biochemical phenomena.Do patients benefit more, however, from the comfortable assertion that they have a "neuro- transmitter problem" and the pharmacological treatments that this inevitably suggests or by doctors addressing the psychosocial stressors that underlie or exacerbate the diseases?Evidence suggests that accepting a medicalising label and its attendant invalid role may be associated with delayed recovery in patients without demonstrable organic disease.'
XANTHOMAS OF THE SKIN
Journal: JAMA (1961)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Rapid Fire ‐ Basic Science 2
Authors: P Kolkhof, ; Delbeck, ; Kretschmer, ; Steinke, ; Hartmann, ; Baerfacker, ; Eitner, ; Albrecht-Kuepper, ; Schaefer, R Janssen, ; Zuidwijk, ; Muller, ; Van Mil, ; Dirkx, ; De Windt, ; Oudejans, ; Simonides, A Gueret, ; Harouki, ; Galmiche, ; Favre, ; Nicol, ; Thuilllez, ; Kolkhof, ; Mulder, ; Jaisser, A Pascaud
Journal: European Journal of Heart Failure (2014)
The Estrogenic Activity of Phthalate Esters in Vitro
Authors: Catherine A. Harris, Pirkko Henttu, Malcolm G. Parker, John P. Sumpter
Journal: Environmental Health Perspectives (1997)

A large number of phthalate esters were screened for estrogenic activity using a recombinant yeast screen. a selection of these was also tested for mitogenic effect on estrogen-responsive human breast cancer cells. A small number of the commercially available phthalates tested showed extremely weak estrogenic activity. The relative potencies of these descended in the order butyl benzyl phthalate (BBP) > dibutyl phthalate (DBP) > diisobutyl phthalate (DIBP) > diethyl phthalate (DEP) > diisiononyl phthalate (DINP). Potencies ranged from approximately 1 x 10(6) to 5 x 10(7) times less than 17beta-estradiol. The phthalates that were estrogenic in the yeast screen were also mitogenic on the human breast cancer cells. Di(2-ethylhexyl) phthalate (DEHP) showed no estrogenic activity in these in vitro assays. A number of metabolites were tested, including mono-butyl phthalate, mono-benzyl phthalate, mono-ethylhexyl phthalate, mon-n-octyl phthalate; all were wound to be inactive. One of the phthalates, ditridecyl phthalate (DTDP), produced inconsistent results; one sample was weakly estrogenic, whereas another, obtained from a different source, was inactive. analysis by gel chromatography-mass spectometry showed that the preparation exhibiting estrogenic activity contained 0.5% of the ortho-isomer of bisphenol A. It is likely that the presence of this antioxidant in the phthalate standard was responsible for the generation of a dose-response curve--which was not observed with an alternative sample that had not been supplemented with o,p'-bisphenol A--in the yeast screen; hence, DTDP is probably not weakly estrogenic. The activities of simple mixtures of BBP, DBP, and 17beta-estradiol were assessed in the yeast screen. No synergism was observed, although the activities of the mixtures were approximately additive. In summary, a small number of phthalates are weakly estrogenic in vitro. No data has yet been published on whether these are also estrogenic in vitro. No data has yet been published on whether these are also estrogenic in vivo; this will require tests using different classes of vertebrates and different routes of exposure.
Most heavy users of sumatriptan take it inappropriately
Journal: BMJ (1998)

Survival benefits of fibrinolysis and early aspirin in acute myocardial infarction are sustained Fibrinolytic therapy for patients with acute myocardial infarction has short term survival benefits, but information about long term effects is limited.Baigent et al (p 1337) report long term survival data from the ISIS-2 trial of intravenous streptokinase and one month's oral aspirin in suspected acute myocardial infarction.They found that the early survival benefits of fibrinolytic therapy persist for at least 10 years and do not seem to increase or decrease with prolonged follow up in any category of patients, including elderly patients.The survival benefits of aspirin also persist and are additional to those of fibrinolytic therapy.
The Herrmannsdorfer-Sauerbruch Diet
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
T's and Blues
Authors: Craig V. Showalter
Journal: JAMA (1980)

Pentazocine, long an abused drug among the medical community, has become popular among street addicts. The tablet form of pentazocine is combined with the antihistamine, tripelennamine, dissolved in water, and injected intravenously. This combination is known as "T's and Blues." Prescribing physicians should be aware of the abuse of these two drugs, particularly since pentazocine in tablet form is often considered of low abuse potential. Patterns of abuse, serious medical complications, and treatment considerations are discussed. (<i>JAMA</i>244:1224-1225, 1980)
Magnesium sulfate and digitalis-toxic arrhythmias
Authors: L. Cohen
Journal: JAMA (1983)

Seven patients with congestive heart failure receiving long-term diuretic treatment (more than three years) experienced idionodal tachycardia in the presence of apparently normal serum digoxin levels. Intravenous bolus administration of magnesium (Mg) sulfate, followed by intramuscular Mg repletion, abolished the digitalis-toxic arrhythmia. The finding of decreased lymphocyte Mg and potassium contents proved the existence of cellular Mg depletion associated with normal serum Mg levels in five patients and with hypomagnesemia in the other two. Decreased cellular Mg content with normal serum Mg level predisposes to digitalis-toxic arrhythmias. (<i>JAMA</i>1983;249:2808-2810)
Winter Scene
Authors: M. Therese Southgate
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lymphomas
Authors: H. M. Abdel-Dayem, H. A. Macapinlac
Journal: Clinical Nuclear Medicine (1998)

Malignant lymphoma usually arises from the haematopoietic cells of B- or T-cell origin, and only rarely from the reticular supporting cells of the bone marrow and lymph nodes. It is one of the rapidly increasing malignancies with a more than 50% increase in incidence over the past 15 years. This is due to several predisposing factors such as the acquired immunodeficiency syndrome, either due to HIV infection or following the use of immunosuppressive drugs for organ transplantation; other predisposing factors include pesticides, previous radiation exposure and viral infection. The course of the disease differs significantly in adults and children.
Free Papers
Authors: A. Sielenkämper, C. M. Martin, S. Madorin, I. Chin-Yee, W. J. Sibbald, H. Ruckoldt, G. Marx, E. Rickels, W. Burchert, B. Vangerow, S. Piepenbrock, P. Kiefer, P. Kosonen, J. Takala, G. Bouachour, P. Richonune, M. C. Rousselet, C. Lemarie, G, J. J. Lejeune, P. Alquier, T. W. L. Scheeren, L. A. Schwarte, A. Fournell, G. Reah, A. Mallick, A. R. Bodenham, R. Przybelski, M. van Iterson, M. Sinaasappel, A. Trouwborst, C. Ince, B. Temmesfeld, K. Mayer, A. Friedland, M. Reich, W. Seeger, F. Grimminger, B. Schwarz, R. Germann, W. Hasibeder, E. Gruber, S. Meusburger, E. Deusch, N. Salak, J. Bonatti, B. Riedmann, D. M. Rosser, R. P. Stidwill, M. Singer, J. P. Revelly, L. Liaudet, Ph. Frascarolo, J. M. Joseph, O. Martinet, M. Markert, W. S. Madorin, R. F. Potter
Journal: Intensive Care Medicine (1996)
Age-Specific Reference Ranges for Prostate-Specific Antigen-Reply
Authors: Joseph E. Oesterling
Journal: JAMA (1994)

<h3>In Reply.</h3> —Our study defines the clinically useful reference ranges for serum PSA concentration according to age, using standard, well-accepted methods.<sup>1,2</sup>The so-called normal level for a given diagnostic marker should be established in a cohort of individuals with no clinical evidence of having the condition that the diagnostic marker is useful for detecting but who are at risk for developing it. For PSA the appropriate cohort is randomly chosen men between 40 and 79 years of age who have no evidence of prostate cancer by currently available diagnostic tests. When there is no clinically relevant lower limit for the diagnostic marker, the 95th percentile is used to determine the upper limit of the reference range. For PSA, these upper limits were found to be age-dependent and are as follows: 40 to 49 years of age, 2.5 ng/mL, and 70 to 79 years of age, 6.5 ng/mL. This increase
Biography
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Scar
Authors: Donna Pucciani
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PURPURA FULMINANS
Authors: DAVID L. CRAM, ROBERT L. SOLEY
Journal: British Journal of Dermatology (1968)

SUMMARY. —A case of purpura fulminans with survival is reported. The pathogenesis of this rare and usually fatal disease is discussed with special reference to its therapeutic implications. Anticoagulants should be administered at the earliest possible stage if life is to be saved and mutilation minimized.
Reporting of outcomes in randomized controlled trials on nail psoriasis: a systematic review
Authors: C.I. Busard, J.Y.C. Nolte, M.C. Pasch, P.I. Spuls
Journal: British Journal of Dermatology (2018)

One of the important complications of the skin disease, psoriasis, is the appearance of changes in the nails. These range from the formation of small pits across the surface of the nail to painful separation of the nail plate from the underlying nail bed and disfiguring enlargement and thickening of the nail itself. Given this wide range of changes in appearance it is important that, in assessing the results of treatment, researchers can use simple, but accurate, criteria for measuring changes in psoriatic nails under treatment; these are known as core outcome sets. This study, organised by investigators from the departments of dermatology in the Universities of Amsterdam and Nijmegen in the Netherlands, surveyed 65 clinical trials focussing on nail psoriasis, all of which used assessment measures for nail changes in psoriasis, the commonest of which is called the nail psoriasis severity index. However, they found that several different methods were used in the various studies. A detailed analysis of these studies has identified a number of variations in the methods used which make the results of different treatments difficult to compare. This is particularly because there was no standard way of expressing the final scores of the severity of nail disease found in these studies and also that the different aspects of severity were rated differently. Some of these assessment scoring systems have not been validated (substantiated) either. The authors call for a rethink of the use of nail assessments in psoriasis and highlight the need to develop new methods which are sufficiently robust to stand up to close scrutiny. These should allow investigators to assess the different changes seen in the diseased nails in a standardised way, so that results of different studies can be compared. They suggest that a consensus group should be established to carry out this work.
GI bleeding
Authors: M Szilard
Journal: Gut (1994)

3rd UEGW Oslo 1994 A211 prised 85% of upper Gl bleedings in this report.The 10.7% total in hospi- tal mortality is similar to that found in literature.However, variceal bleeding treated with sclerotherapy had a 28% mortality, lower than previously reported.Therapeutical endoscopy therefore, has a positive impact on mortality from Gl bleeding due to esophageal varices.
Unintended consequences of health information technology: Evidence from Veterans Affairs Colorectal Cancer Oncology Watch Intervention.
Authors: John Bian, Charles L. Bennett, Deborah Fisher, Maria Leonor Ribeiro, Joseph Lipscomb
Journal: Journal of Clinical Oncology (2012)

6044 Background: Although health information technology (HIT) has been hypothesized to help achieve greater adherence to recommended clinical guidelines and increase use of preventive care, well-conducted empirical studies evaluating this hypothesis are lacking. This study evaluated the ongoing Colorectal Cancer (CRC) Oncology Watch intervention, a clinical reminder system, implemented in 8 Veterans Affairs (VA) hospitals in 2008 for improving CRC (1) screening adherence among average- or higher-risk veterans, and (2) surveillance. Methods: VA administrative data were used to construct 4 cross-sectional groups of average-risk age 50-64 veterans, one for each of 2006, 2007, 2009, and 2010. We applied a linear probability model with hospital fixed-effects for estimation, using a natural experiment in which the 8 hospitals served as the intervention and other 121 hospitals as a control and with 2006-2007 designated as the pre-intervention period and 2009-2010 as the post-intervention period. Results: The sample included 4,352,082 veteran-years in 4 years. The proportions adherent to screening were 37.6%, 31.6%, 34.4%, and 33.2% in the intervention in 2006, 2007, 2009, and 2010, respectively, and the corresponding proportions in the control were 31.0%, 30.3%, 32.3%, and 30.9%. Regression analysis showed that among those eligible for screening, the intervention was associated with a 2.2-percentage-point decrease in likelihood of adherence (P-value&lt;0.0001). Additional analyses showed that the intervention was associated with a 5.6-percentage-point decrease in likelihood of screening by colonoscopy among the adherent, but with increased total colonoscopies (any indication) of 3.6 per 100 veterans age 50-64. Conclusions: The intervention may have slightly reduced CRC screening rates for the studied population. This consequence may have been caused by an unintentional shift of limited VA colonoscopy capacity from average-risk screening to higher-risk screening and to CRC surveillance, or by physicians’ fatigue due to the large number of clinical reminders implemented in the VA.
Prolonged Fecal Excretion of Hepatitis A Virus in Adult Patients With Hepatitis A As Determined by Polymerase Chain Reaction
Authors: H Yotsuyanagi, K Koike, K Yasuda, K Moriya, Y Shintani, H Fujie, K Kurokawa, S Iino
Journal: Hepatology (1996)

In hepatitis A virus (HAV) infection, fecal excretion of the virus has been reported to cease shortly after symptoms occur. Although there have been several reports on detection of HAV in feces using polymerase chain reaction (PCR), the duration of fecal HAV shedding in human adult hepatitis A has not been well described. In the present study, we applied the reverse–transcription (RT)–PCR system to the detection of fecal HAV RNA in 10 patients with sporadic hepatitis A. The viral genomic RNA was detected in the stools from five patients after the onset of clinical symptoms. All stool samples collected within 10 days of onset of illness were HAV–RNA–positive, and the duration of positivity lasted from a few days to as long as 3 months. In four patients, HAV RNA was detected in the stool even after the serum alanine transaminase (ALT) levels had peaked, and in one patient well after ALT levels fell to normal. These results show that fecal shedding of HAV can last for months after resolution of symptoms and such patients could be a source of further spreading of the virus in the community.
Continuity of outpatient medical care in elderly men. A randomized trial
Authors: J. H. Wasson
Journal: JAMA (1984)

If an outpatient repeatedly sees the same practitioner, is his care influenced? This double-blind randomized trial examines the effects of outpatient health care provider continuity on the process and outcome of the medical care for 776 men aged 55 years and older. Participants were randomized to two different groups of provider care: provider discontinuity and provider continuity. The outcome of the continuity group was significantly different from that of the discontinuity group. During an 18-month period, patients who had been randomized to the continuity group had fewer emergent admissions (20% v 39%) and a shorter average length of stay (15.5<i>v</i>25.5 days). These patients also perceived that the providers were more knowledgeable, thorough, and interested in patient education. We conclude that continuity of outpatient provider care for men aged 55 years and older results in more patient satisfaction, shorter hospitalizations, and fewer emergent hospital admissions. (<i>JAMA</i>1984;252:2413-2417)
Information in natural languages. A new approach
Authors: P. A. Shapiro
Journal: JAMA (1969)

Existing units of "information" fail to have any close correspondence with what we normally mean by the word information. We propose a new measure, the "kernel" which seems to possess five properties which are desirable for any proposed unit of information. We have developed an automated method for extracting kernels of information from the text of surgical operative reports. We can retrieve the information by asking questions in ordinary English. The first step is a dictionary look-up of the form class (similar to "parts of speech") and the seme number (identifying synonymous words) of each work in the operative report. A syntactic analysis and a transformational analysis is then performed to extract the kernels of information. To retrieve information, the questions are analyzed in the same way. The kernels thus obtained are matched to the kernels that have previously been catalogued. This retrieves the specific information that answers the question.
Author Corrections
Journal: Journal of Clinical Oncology (2011)

In Table 3, the amino acid change for patient No. MB5 was given as p.G33R, whereas it should have been p.G34R.For patient No. MB36, the nucleotide change was given as c.CϾA, whereas it should have been c.GϾA, and the amino acid change was given as p.D32E, whereas it should have been p.D32N.Also, the amino acid change was given as p.S32F for patient No. MB42 and p.G34R for patient No. MB46, whereas it should have been p.S33F and p.G34E, respectively.