tbuckley/cabot-search huggingface dataset:
Meniere’s
Authors: Sue Walker
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 201: High Fat Diet Selectively Decreases the Bone Marrow Lin-/c-kit+ Cell Population in Aging Mice Through Increased ROS Production
Authors: Yichao Xiao, Xuanyou Liu, Qingyi Zhu, Meng Jiang, Hong Hao, Govindasamy Ilangovan, Hua Zhu, Qiming Liu, Shenghua Zhou, Zhenguo LIU
Journal: Circulation Research (2017)

Bone marrow-derived c-kit-positive (c-kit + ) cells are a potential source for cell-based therapy and tissue repair and regeneration. The ability of tissue repair and regeneration is significantly decreased in the aging population for various reasons. Western diet usually has increased level of fat. The present study was designed to evaluate the effect of long-term high fat diet on bone marrow c-Kit positive cells and the role of ROS in aging mice. Aging male wild-type (WT) C57BL/6 mice (40 weeks) were fed with high fat diet (HFD) for 3 months with regular diet as the control. To evaluate the role of reactive oxygen species (ROS) in mediating the effect of HFD on bone marrow cell population, a separate group of mice were treated with N-acetylcysteine (NAC) to reduce ROS production. Bone marrow (BM) and blood cells were harvested and prepared in the mice after 3 months of HFD treatment for flowcytometry analysis for Sca-1+, or c-Kit+, or CD133+ cells. The lineage negative (Lin-) and c-Kit positive (Lin-/c-Kit+) cell population was significantly decreased in the BM, not in blood, in the mice with HFD, while no significant change was observed in Sca-1+ or CD133+ cell populations in the BM or blood. The BM Lin-/c-Kit+ cells also exhibited increased intracellular ROS level, increased level of apoptosis, and deceased level of proliferation in HFD-treated mice. NAC treatment significantly decreased intracellular ROS level and normalized the BM Lin-/c-Kit+ cell population in HFD mice. In conclusion, the present study demonstrated that long-term HFD selectively decreased BM Lin-/c-Kit+ cell population in the aging mice through increased ROS production.
Combination of a second generation genetically modified herpes simplex virus 1 (HSV1) with paclitaxel in the treatment of breast cancer in vitro
Authors: J. C. Hu, G. Hallden, C. Shorrock, G. Simpson, R. Coffin, T. Kamalati, C. Coombes
Journal: Journal of Clinical Oncology (2004)

723 Background: A genetically modified oncolytic HSV1 JS1/ICP34.5-/ICP47- encoding GM-CSF is in a Phase I clinical trial in a number of solid tumours. Preliminary results are encouraging and a Phase II clinical trial in combination with chemotherapy in breast cancer is planned. The aim of the work is to assess the effects of combining the virus and paclitaxel in breast cancer cell lines and to study the mechanism of action of the virus in combination with paclitaxel. Methods: Breast cancer cell lines MDA-MB-231 and MCF-7 were treated with virus, paclitaxel or in combination at different ratios. Cell viability was determined by MTS assays, dose response curves generated and IC50 values estimated and analysed using isobolograms. Cell cycle analysis was performed after propidium iodide (PI) staining using FACS. Apoptosis was assessed with annexin V and PI staining. Effects on viral replication were assessed by plaque assay. Results: The effects of combining JS1/ICP34.5-/ICP47- given prior to, with, or after paclitaxel were either synergistic or additive. For example, for MDA-MB-231, a combination IC50 value was 2x10-4pfu/ml (virus) with 5nM of paclitaxel, but 5x10-5pfu/ml and 20nM respectively alone. This indicated synergism at this ratio. Other ratios indicated at least additive effects.Work to elucidate the mechanisms of this additivity/synergy demonstrated that: - the virus blocks the cell cycle of MCF-7 cells at G1/S and causes some apoptosis; - paclitaxel blocks the cycle at G2/M and causes significant apoptosis; - apoptosis appears not to be enhanced by the combination of drug and virus; - paclitaxel does not affect virus replication. Conclusions: The combination of JS1/ICP34.5/ICP47- with paclitaxel may be beneficial in the treatment of breast cancer as isobolograms show either additivity or synergy. However, synergy did not appear to result from an augmentation of virus replication and was not the result of an increase in the number of cells undergoing apoptosis. Further studies are underway to elucidate the molecular events underlying these findings. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration BioVex Limited; Hammersmith Hospital BioVex Ltd.
OPEN AIR TREATMENT OF SURGICAL TUBERCULOSIS.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE SURGICAL TREATMENT OF TUBERCULOUS CERVICAL LYMPH GLANDS.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Paradoxical septal motion secondary to right ventricular tumor
Authors: L. Sasse
Journal: JAMA (1975)

TO OUR knowledge, this is the first report of echocardiographically studied rhabdomyosarcoma of the heart. Square-wave paradoxical septal motion was noted. In the absence of previously reported causes of paradoxical septal motion, right ventricular tumor appears to be a newly recognized cause of paradoxical septal motion. <h3>Report of a Case</h3> A normotensive 59-year-old woman with a long history of spastic colon symptoms was admitted during a bout of near syncope. A presystolic "seagull" murmur at the lower part of the left sternal border and elevated jugular venous pressure, both of which increased on inspiration, an early systolic ejection murmur, which decreased with inspiration, a prominent jugular A wave, and a normal second heart sound were demonstrated (Fig 1). There was mild peripheral cyanosis. Electrocardiographic axis was +120°, with tall R waves in right precordial leads and a QRS complex duration of 0.10 seconds, while an electrocardiogram eight months earlier was
Miscellany
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Outcomes After Out-of-Hospital Cardiac Arrest Treated by Basic vs Advanced Life Support
Authors: Henry E. Wang, Douglas F. Kupas
Journal: JAMA Internal Medicine (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
The Risk of Childhood Cancer from Intrauterine and Preconceptional Exposure to Ionizing Radiation
Authors: Richard Wakeford
Journal: Environmental Health Perspectives (1995)

The findings of studies investigating whether exposures to ionizing radiation before birth, either pre- or post-conception, increase the risk of childhood cancer have provoked much scientific controversy. An epidemiological association between the abdominal exposure of pregnant women to diagnostic X-rays and childhood cancer was first reported in the 1950s, while an association between the recorded dose of radiation received occupationally by fathers before the conception of their offspring and childhood leukemia was reported only recently in 1990. The scientific interpretation of these particular statistical associations is by no means straightforward, but the latest analyses of intrauterine irradiation and childhood cancer indicate that a causal inference is likely. Scientific committees have adopted risk coefficients for the intrauterine exposure of somatic tissues, which for childhood leukemia are comparable to those accepted for exposure in infancy, although questions remain about the level of risk of childhood solid tumors imparted by exposure to radiation in utero and shortly after birth. In contrast, the association between paternal preconceptional radiation dose and childhood leukemia has not been confirmed by studies using objectively determined doses. The original association has been found to be restricted to children born in one village, it does not extend to cancers other than leukemia, and it is markedly inconsistent with the established body of knowledge on radiation-induced hereditary disease. A causal interpretation of this association has effectively been abandoned by scientific authorities.
Outbreak of Powassan Encephalitis—Maine and Vermont, 1999-2001
Journal: JAMA (2001)

Powassan (POW) virus, a North American tickborne flavivirus related to the Eastern Hemisphere's tickborne encephalitis viruses, was first isolated from a patient with encephalitis in 1958. During 1958-1998, 27 human POW encephalitis cases were reported from Canada and the northeastern United States. During September 1999-July 2001, four Maine and Vermont residents with encephalitis were found to be infected with POW virus. These persons were tested for other arbovirus infections found in the northeast after testing for West Nile virus (WNV) infection was negative. This report describes these four cases, summarizes the results of ecologic investigations, and discusses a potential association between ticks that infest medium-sized mammals and the risk for human exposure to POW virus. The findings underscore the need for personal protective measures to prevent tick bites and continued encephalitis surveillance.
Impact of Clostridium difficile infection on gastrointestinal malignancies.
Authors: Stuthi Perimbeti, Rishi Shrivastav, Karan Jatwani, Kristine Marie Ward, Michael Styler, Maneesh Rajiv Jain, Neilanjan Nandi
Journal: Journal of Clinical Oncology (2019)

e15586 Background: According to the Centers for Disease Control and Prevention, there were half a million documented cases with 83,000 re-infections and 29,000 deaths due to Clostridium Difficile Infection(CDI) in the year 2011. The influence of CDI on outcomes in gastrointestinal(GI) malignancies is not well described, although the incidence is known to be higher in this subgroup of patients. Methods: National Inpatient Sample 1999-2014 was analyzed to identify adult admissions (&gt;18 years of age) using ICD-9-CM codes with a primary diagnosis of esophageal(EC), Gastric(GC), Colorectal(CRC), Small intestinal(SIC), Hepatobiliary(HCC) and Pancreatic(PC) cancers. ICD-9 code 00845 was used to stratify these for the presence of CDI. We performed Chi-Square test to determine the in-hospital mortality percentage, and Cox Proportional Hazard model to control for confounders and determine the Hazard Ratio(HR) of death within 30 days of admission during hospitalization in patients with and without CDI. Results: See Table. Conclusions: Despite controlling for potential confounders, patients with GI cancers and CDI are at an increased risk of death compared to those without CDI. Taking the more detrimental effects of CDI in this subgroup of patients into consideration, healthcare professionals should strive to avoid the inordinate use of antibiotics and strictly maintain current guidelines designed to prevent spread. It may be prudent to treat these patients as severe CDI, even if current criteria are not met. More scientific research is warranted in analyzing the specific outcomes of CDI in GI cancer patients and if more aggressive therapy for CDI is warranted, considering the limitations of this study. [Table: see text]
长波长紫外线A1和可见光对色素淀积和红疹的协同效应
Authors: I. Kohli, S. Chaowattanapanit, T.F. Mohammad, C.L. Nicholson, S. Fatima, G. Jacobsen, N. Kollias, H.W. Lim, I.H. Hamzavi
Journal: British Journal of Dermatology (2018)

太阳光到达地面的紫外线(UV)辐射分为UVB(波长范围280~320 nm)和UVA (320~400 nm)。UVA进一步分为UVA2 (320~340 nm)和UVA1 (340~400 nm)。美国和其他国家已规定了防UVB和UVA产品的检验方法,此外对这些产品的标签方式也有严格规定。SPF(防晒指数)主要是指仅抵抗UVB的保护程度,SPF连同标签上的“广谱”显示的是对UVB和UVA的防护。在美国,决定制造商是否可宣传产品提供广谱保护的标准主要是针对370 nm以下的防护。可见光(VL)的波长范围为400 nm至700 nm,是人眼可见的波长的范围。到目前为止,只有太阳光的UV部分(不可见光)被认为会引起光损伤(太阳光造成的损伤),导致皮肤癌和光老化(太阳造成的皮肤老化)。太阳光的可见部分相对无害。这项来自美国的研究调查了可见光混合长波长UVA1尾端(被称为VL+UVA1,370~700 nm)造成的皮肤反应(晒斑和美黑方面),并将其与纯可见光(400~700 nm)造成的皮肤反应进行对比。研究发现显示,由VL+UVA1导致的色素沉积(变色/变黑)以及红疹(红斑/晒斑)方面的皮肤反应强于纯可见光引发的反应。这说明,现有广谱防晒霜未覆盖的波长会影响色素沉积和红疹。这些波长可能导致了接触阳光加重的疾病(例如黑斑病和皮肤发炎后的色素沉积),尤其是对于有色人种患者。防可见光和长波长UVA1产品的研发对这些人群有益,同时还有益于管理UVA1和VL触发的某些皮肤病。
Painful Lessons
Authors: Michael P. McCarthy
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
<i>Announcement:</i> National Chronic Obstructive Pulmonary Disease Awareness Month — November 2016
Journal: MMWR Morbidity and Mortality Weekly Report (2016)

Approximately 15.7 million U.S. adults have received a diagnosis of chronic obstructive pulmonary disease (COPD), which includes chronic bronchitis and emphysema (1).However, many more adults with symptoms of COPD, including frequent coughing, shortness of breath, excess phlegm or sputum production, wheezing, or difficulty taking a deep breath, might not be aware that they have COPD, or they may not be receiving treatment for COPD because they have never received a diagnosis.Geographic variations in the availability of primary care physicians and COPD specialists for the U.S. population suggest that 3.7 million adults do not have access to a pulmonologist within 50 miles; in many counties where patients have access to a pulmonologist within 50 miles, the COPD patient-to-pulmonologist ratio may exceed 6,000 (2).Therefore, early diagnosis, treatment, and management Announcementof COPD is dependent on adults communicating COPD symptoms to their primary care physician.November is National COPD Awareness Month, an observance supported by the National Heart, Lung, and Blood Institute's campaign, "COPD: Learn More, Breathe Better."This year's theme, "Spotlight on COPD," will raise awareness about the signs and symptoms of COPD, and encourage persons with symptoms to speak to their physicians.More information about COPD is available at http://www.cdc.
Correction: Cholangioscopy-guided lithotripsy for difficult bile duct stone clearance in a single session of ERCP: results from a large multinational registry demonstrate high success rates
Authors: Amit P. Maydeo, Rungsun Rerknimitr, James Y. Lau, Abdulrahman Aljebreen, Saad K. Niaz, Takao Itoi, Tiing Leong Ang, Jörg Reichenberger, Dong Wan Seo, Mohan K. Ramchandani, Benedict M. Devereaux, Jong Kyun Lee, Mahesh K. Goenka, Randhir Sud, Nam Q. Nguyen, Rakesh Kochhar, Joyce Peetermans, Pooja G. Goswamy, Matthew Rousseau, Surya Prakash Bhandari, Phonthep Angsuwatcharakon, Raymond S. Y. Tang, Anthony Y. B. Teoh, Majid Almadi, Yun Nah Lee, Jong Ho Moon
Journal: Endoscopy (2019)

Correction to: Cholangioscopy-guided lithotripsy for difficult bile duct stone clearance in a single session of ERCP: results from a large multinational registry demonstrate high success ratesEndoscopy 2019; 51(10): 922-929DOI: 10.1055/a-0942-9336
ASSOCIATION NEWS.
Authors: John V. Shoemaker
Journal: JAMA (1898)

<b>Prof. Samuel C. Busey</b>, who was elected to deliver the annual oration on State Medicine, has resigned the position. The members will learn this with regret, and also that the ill-health of Professor Busey was the cause of his resignation. <h3>Section on Materia Medica and Therapeutics.</h3> —The following papers and discussions have been promised for the meeting at Denver, Colo., June 7-10, 1898: Yellow Fever; discussion by Surgeon-General Geo. M. Sternberg of Washington, D. C.; Prof. John Guiteras of Philadelphia, Sollace Mitchell of Jacksonville, Fla.; T. S. Scales of Mobile, Ala.; G. B. Thornton of Memphis, Tenn., and H. M. Bracken of Minneapolis, Minn. Aims of Modern Treatment of Tuberculosis, by Prof. Edwin Klebs of Chicago. Serum Therapy of Tuberculosis, by Prof. S. O. L. Potter of San Francisco. The Use of Remedies in Diseases of the Heart and Blood Vessels, by T. Lauder Brunton, M.D., D.Sc., F.R.S., London, England.
Highlights
Journal: JAMA (2018)

Early treatment of nausea and vomiting in pregnancy can provide symptom relief and prevent progression to hyperemesis gravidarum.In a retrospective cohort study of 1 816 414 pregnancies, Huybrechts and colleagues found that fi rst-trimester exposure to the antiemetic ondansetron was not associated with cardiac malformations or congenital malformations overall, but was associated with a small increased risk of oral clefts.An Editorial by Haas discusses treatment options for women with nausea and vomiting during pregnancy.
Firearm-Related Deaths— Louisiana and Texas, 1970-1990
Journal: JAMA (1992)

In 1990, firearm-related injuries surpassed motor-vehicle crashes as the leading cause of death from injuries in both Louisiana and Texas, and from 1979 through 1987, these states ranked third and fifth, respectively, for age-adjusted firearm-related death rates. Because firearm-related injuries are a major cause of death in Louisiana and Texas, the Louisiana Disability Prevention Program, Louisiana Office of Public Health, and the Injury Control Program, Epidemiology Division, Texas Department of Health, used death certificates to examine patterns in firearm-related mortality. This report summarizes the analysis of death certificate data for firearm-related mortality in these two states.