tbuckley/cabot-search huggingface dataset:
High Altitude
Journal: JAMA (1999)

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Tourniquet Paralysis
Authors: William K. Hamilton
Journal: JAMA (1967)

Two cases are presented to illustrate a complication which understandably could happen in spite of attention and precautions. The first patient was a man undergoing surgical therapy for Dupuytren's contracture. During performance of axillary block, median nerve paresthesias were elicited. The block was not completely satisfactory and required supplementation with general anesthesia. Postoperatively, the patient complained of numbness in the radial-nerve distribution. This numbness rapidly lessened in the early postoperative period and completely disappeared during a period of postoperative follow-up. Total tourniquet time was 28 minutes, at a gauge pressure of 250 mm Hg. The second patient also had excision of Dupuytren's contracture on the same day, in the same operating room. General anesthesia was used for this patient. Postoperatively, he complained of inability to move his fingers and of numbness of the long, ring, and small fingers. These findings improved rapidly immediately, and returned to normal during the follow-up
Effects of blockade of Kupffer cells by gadolinium chloride on hepatobiliary function in cold ischemia-reperfusion injury of rat liver.
Authors: M Kukan
Journal: Hepatology (1997)

The mechanisms of liver injury from cold storage and reperfusion are not completely understood. The aim of the present study was to investigate: 1) whether the inactivation of Kupffer cells (KCs) by gadolinium chloride (GadCl) modulates cold ischemia-reperfusion injury of rat liver; and 2) whether cold storage of rat liver involves injury to biliary epithelial cells (BECs). Hepatobiliary function was assessed using an isolated perfused rat liver model. Compared with control livers, in livers subjected to cold storage at 4°C in Euro-Collins solution (EC) for 18 hours or in University of Wisconsin solution (UW) for 48 hours, portal flow was lower and resistance significantly higher, taurocholate (TC) and bromosulfophthalein (BSP) elimination were markedly impaired, bile flow was reduced, and lactate dehydrogenase (LDH) leakage into the perfusate was increased. Pretreatment of rats with GadCl, a selective KC toxicant, abrogated disturbances of the microcirculation in both models, but it did not influence viability and functional parameters of the liver. Most of the parameters studied in livers stored in UW solution for 18 hours were not significantly different from those found in control livers. As to biliary activity of γ-glutamyl transferase (GGT), as an index of BEC integrity, it was increased with increasing time of cold storage. The reabsorption of glucose from the bile decreased with longer storage time. The results suggest the following: 1) that cold ischemia- reperfusion injury of rat liver is mediated by KC-dependent (hepatic microcirculation) and -independent (parenchymal cell function) mechanisms; and 2) that cold storage of rat liver induces functional impairment of BECs. (Hepatology 1997 Nov;26(5):1250-7)
Altitude induced illness.
Authors: I. P. Hall, A. T. Cole
Journal: BMJ (1992)

article by Eysenck was published,3 based mainly on the work of Grossarth-Maticek.Over 15 commentaries, nearly all of them highly critical, have addressed the statements made by Eysenck (and Grossarth-Maticek).In my commentary I described part of a study reanalysing the data collected by Grossarth-Maticek.4I concluded that information about survival and mortality, as provided by Grossarth-Maticek, in some treated and control subjects from the individual treatment study is misleading and does not represent actual longevity due to a mix up of names, addresses, and actual cause of death.I also showed that Eysenck and Grossarth-Maticek published in 19915 mortality data that they had withdrawn in 1988.In my commentary I also stated that the treatments, as described by Grossarth-Maticek and Eysenck,5 were not fully documented.Inspection of a German language source shows that the individual treatment included many more detailed ingredients, such as taking part in an exercise programme, changes in the diet, and taking vitamins and medications.It is a disservice to scientists, therapists, and patients that the "revolutionary" results ofEysenck and Grossarth-Maticek could have been published without adequate description of all the methods used to obtain them.Colleagues and I have shown that psychosocial interview responses and some somatic data (blood cholesterol concentration and the number of leucocytes) were used twice in Grossarth-Maticek's Heidelberg studies.89All of this is bad news for the trustworthiness of Grossarth-Maticek's data from the Heidelberg studies of 1972.
Section 8: Systemic Lupus Erythematosus
Journal: JAMA (1973)

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THE AMERICAN VOICE.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SCHOOL HYGIENE
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A CO-OPERATIVE BACTERIOLOGIC INVESTIGATION.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Complications with heparin-lock needles
Authors: G. J. Couchonnal
Journal: JAMA (1979)

The incidence of phlebitis was determined for heparin-lock needles after use of three different methods of skin preparation and follow-up care. Phlebitis was significantly more frequent when iodophor solution and iodophor ointment, respectively, were used than when iodophor solution alone was used for heparin-lock needles in use longer than 48 hours, with more than ten manipulations of the systems, and when only one drug was infused through the systems. Iodophor solution skin preparation followed by daily application of iodophor solution is recommended to minimize the occurrence of associated phlebitis. (<i>JAMA</i>242:2098-2100, 1979)
Abstract 256: Repurposing neuroleptic drug for brain tumor therapy
Authors: Iti S. Kaushik, Alok Ranjan, Blake Schwettmann, Sanjay Srivastava
Journal: Cancer Research (2019)

Abstract Brain tumor is considered as one of the most aggressive and incurable form of cancer. Majority of the brain tumors have a median survival rate of only 12%. Even though advanced treatments such as surgical removal, chemotherapy and radiotherapy are available, brain tumor persists to be lethal. Temozolomide (TMZ) is the main therapy for brain tumor but resistance to TMZ is the major cause of treatment failure. This resistance in tumor cells has frequently been linked to the expression of O6-methylguanine-DNA methyltransferase (MGMT). Pimozide (PMZ) is a neuroleptic drug used for the treatment of schizophrenia and chronic psychosis. In our study, we observed that pimozide significantly reduced the viability of U87MG, U251MG, DAOY and GBM28 cell lines with an IC50 ranging from 11µM to 20µM after 24 h of treatment. Pimozide induced apoptosis in these cell lines as evaluated by FITC/Annexin assay and further validated by the cleavage of caspase 3 as well as PARP. Western blot analysis resulted in the concentration dependent decrease in the expression of STAT3 signaling mainly targeting the anti-apoptotic markers BCl-XL, BCl-2 and Survivin etc in U87MG, U251MG, DAOY and GBM28 brain cancer cell lines. PMZ alone suppressed the growth of U87MG cells with an IC50 of 10µM, after 96 hours of treatment. On the other hand, treatment of U87MG cells with 750 µM of TMZ in combination with 10µM PMZ for 96 hours increased the killing of U87MG cells by 50% as compared to 10% when treated with TMZ. In addition, PMZ treatment reduced the survival of TMZ resistant U251R cells with an IC50 ranging from 15-20 µM after 24 h of treatment. Our results further demonstrated that oral administration of PMZ (25mg/kg) significantly inhibits the growth of brain tumors in an intracranial tumor model without any apparent signs of toxicity. It is important to note that PMZ is an FDA approved drug with no considerable toxicity. Overall, this study depicts that PMZ is a potential candidate to target brain tumors. Citation Format: Iti S. Kaushik, Alok Ranjan, Blake Schwettmann, Sanjay Srivastava. Repurposing neuroleptic drug for brain tumor therapy [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 256.
Course and Prognosis of Untreated Histoplasmosis
Journal: JAMA (1961)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Vaginitis
Authors: Jack D. Sobel
Journal: New England Journal of Medicine (1997)

Symptoms of vaginitis are nonspecific, and neither self-diagnosis nor diagnosis by a physician is reliable without laboratory confirmation. The management of vaginitis remains largely empirical, and many assume that vaginitis is never life-threatening and that empirical therapy is always harmless. Vulvovaginitis, although frequently the result of infection, may also have noninfectious causes (Table 1); moreover, mixed infections are not uncommon.Candida VulvovaginitisThe epidemiologic data on candida vulvovaginitis, a nonreportable disease, are incomplete. Prevalence estimates rely mainly on self-reported histories of diagnosis by a physician. Vulvovaginal candidiasis is routinely diagnosed without the benefit of microscopy or culture, and as many . . .
In Memoriam
Authors: Bengt Arnetz, N. Sonino, E. Scarpa, A. Paoletta, F. Fallo, M. Boscaro, M. Biondi, A. Picardi, Bo H. Jonsson, Töres Theorell, Sarah Thomsen, Joaquim Soares, Peter Nolan, Janie Dallender
Journal: Psychotherapy and Psychosomatics (1999)
AND IT CAME TO PASS...
Journal: JAMA (1967)

Intense study of a recently discovered inscription has yielded the following translation. Although the original inscription has not yet been properly dated, it probably belongs to the reign of Titmouse the third, who died shortly before Hippocrates was born. Some parts of the translation may be subject to alternate readings, but we must leave the final decision to specialists. In the days not long after the Great Flood, before the Great Sun shone upon the land, there were learned societies which were small and meager and they were known as Royal Societies and Royal Academies, and it was a great honor to belong, and they were at first few and tender. And they published Proceedings which were small and tender, which scholars consulted with pleasure. And the Great Sun shone and the land waxed warm and the Academies proliferated. And they suffered mutations so that some societies were no longer
Eléments de chimie organique biologique: Introduction chimique à l'étude de la biologie générale
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical Trials in Cancer Research
Authors: Edmund A. Gehan
Journal: Environmental Health Perspectives (1979)

This is a review paper which gives a discussion of various aspects of clinical trials in cancer research. Since the conduct of the first randomized controlled clinical trial in cancer patients in the mid-1950's, substantial progress has been made in the utilization of the clinical trial technique for the evaluation of therapeutic efficiacy. The important elements of a protocol are given with some discussion of items to be considered in designing a protocol. The types of clinical trial (phase I, II, III) are defined, and the place of each phase of study in the context of the search for new treatments is delineated. A comprehensive discussion is given of the elements in the comparative clinical trial (phase III), including objectives, consierations in planning (comparability of treatment groups stratification of patients, feasibility and size of study, and prospective versus retrospective studies). Brief descriptions are given of designs for comparative clinical trials and a trial in oat cell lung carcinoma is discussed in some detail. Finally, some comments and references are given concerning the analysis of clinical trials.
Error in Abstract Results
Authors: Young Lim, Keith Choate, Jean-Phillip Okhovat
Journal: JAMA Dermatology (2017)

the result of our graphics software misaligning the reads with the histogram above it, causing a strange step-off to be seen.Herein, we provide a correctly aligned Figure.In addition, the original Figure 3B caption incorrectly stated that there were 26 nonreference calls (C) and 11 reference calls (A), for a ratio of 70% nonreference.Instead, the numbers should be flipped: there are 26 reference calls and 11 nonreference calls, for a nonreference ratio of 30%.This has also been corrected in the Figure legend.None of the study's conclusions are affected by these errors or their corrections.
The future of stereotaxic surgery
Authors: J. E. Adams
Journal: JAMA (1966)

Stereotaxic surgery in humans was first reported in 1947<sup>1</sup>despite the fact that it has been per formed in animals since 1908.<sup>2</sup>In animals, the location of the target area in the brain could be determined from bony landmarks of the skull since the relationship between such landmarks and the various intracerebral, subcortical structures was remarkably constant. In humans, however, it became obvious that these relationships were not precise and internal landmarks, such as the anterior or posterior commissures, had to be established. By the use of such internal landmarks, it became possible to place an electrode into a predetermined, subcortical location with an error of not greater than 1 mm. Primarily because this precision<i>was</i>possible and because a properly placed stereotaxic lesion<i>could</i>abolish the rigidity and tremor of Parkinson's disease, stereotaxic techniques developed rapidly—by August, 1965, over 24,000 stereotaxic procedures had been performed in various countries.<sup>3</sup>
Orphan Products: Origins, Progress, And Prospects
Authors: M. Haffner
Journal: The Annual Review of Pharmacology and Toxicology (1991)

Heme oxygenases (HO) catabolize free heme, that is, iron (Fe) protoporphyrin (IX), into equimolar amounts of Fe2+, carbon monoxide (CO), and biliverdin. The stress-responsive HO-1 isoenzyme affords protection against programmed cell death. The mechanism ...Read More