tbuckley/cabot-search huggingface dataset:
Bisphenol A Diglycidyl Ether as a Potential Metabolic Source of Bisphenol A
Authors: D. H. Hutson
Journal: Environmental Health Perspectives (1998)

Bisphenol A Diglycidyl Ether as a Potential Metabolic Source of Bisphenol A * Ethylene glycol monobutyl ether-used as a solvent for mineral oils in spray lacquers, vamish removers, and metal cleaners * Glutaraldehyde-used as a disinfectant and sterilizing agent, and in adhesives, electrical products, dental materials, tanning of leathers, and photographic developing * Methyleugenol-used as an insect altrctant and as a maior constituent of clove oil, which is used in spices, perfumes, and favorings * Oxymetholone-used to promote weight gain and in the treatment of debilitafing diseases, serious infections, bums, trauma, and anemia * Triethanolamine-used in the manufacture of surfactants, textiles, waxes, polishes, herbicides, toilet goods, oil emulsions, and pharmaceuticals
Abstract 25: Identifying new inhibitors of ABCG2 by high-throughput screening
Authors: Shoji Kokubo, Shinobu Ohnuma, Hideaki Karasawa, Akihiro Yamamura, Hideyuki Suzuki, Megumi Murakami, Norihiko Sugisawa, Keigo Kanehara, Keisuke Sato, Takanori Ishida, Takashi Kamei, Takeshi Naitoh, Michiaki Unno
Journal: Cancer Research (2019)

Abstract Background: ABCG2, also known as breast cancer resistance protein (BCRP), is a member of the ATP-binding cassette (ABC)-family of membrane transport proteins associated with multidrug resistance (MDR). No ABCG2 inhibitor has shown clinical significance yet. Aim: To identify novel inhibitors of ABCG2 by high-throughput screening. Material &amp; Methods: After higher expression of ABCG2 in HCT-116/BCRP cells was confirmed by flow cytometry (FACSVerse) using 5D3 antibody, high-throughput fluorescent cell-based assay was performed with the original chemical library of Tohoku University containing about 6000 compounds using ABCG2-specific fluorescent substrate, Pheophorbide a (PhA) in HCT-116/BCRP cells overexpressing ABCG2. Ko143, a potent ABCG2 inhibitor, was used as positive control. Fluorescence intensity in the cells was read by a fluorescence plate reader (SpectraMax M2e) in bottom read mode, with 395 nm excitation, 670 nm emission. To validate the results, flow cytometry assay was performed with 10 µM PhA in HCT-116/BCRP cells. The fluorescence intensity was analyzed by flow cytometry (FACSVerse). Results: Fluorescenct cell-based assay with high-throughput screening could detect 23 candidate compounds, which showed higher fluorescence intensity as positive control Ko143 showed. Then, these 23 compounds were validated with flow cytometry assays. The flow cytometry assays revealed that 16 compounds increased fluorescence intensity of PhA in HCT-116/BCRP cells in dose dependent manner, suggesting that these candidate compounds inhibited transport function of ABCG2. Among 16 compounds, 6 compounds showed further inhibitory effect for transport function of ABCG2 as equivalent to that of Ko143. Conclusion: These 6 compounds may provide a basis for further investigation of ABCG2 function. Citation Format: Shoji Kokubo, Shinobu Ohnuma, Hideaki Karasawa, Akihiro Yamamura, Hideyuki Suzuki, Megumi Murakami, Norihiko Sugisawa, Keigo Kanehara, Keisuke Sato, Takanori Ishida, Takashi Kamei, Takeshi Naitoh, Michiaki Unno. Identifying new inhibitors of ABCG2 by high-throughput screening [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 25.
Gonorrhea in the obstetric and gynecologic clinic. Incidence in a voluntary hospital in an urban community
Authors: V. G. Cave
Journal: JAMA (1969)

Eight hundred and seventy-five patients admitted to the obstetric and gynecologic clinics of a large voluntary hospital in an urban community were examined routinely for gonorrhea with smears and cultures of specimens from the urethra, cervix vagina, and, in 153 instances, from the anal canal. Seventy-two cases of gonorrhea were proved, for a rate of infection of 8.2%. The rate of infection in the obstetric group was 5.5%, and in the gynecologic group, 11.1%. An additional eight patients with positive smears but negative cultures make a total of 80 cases of diagnosed or presumptive gonorrhea, for a rate of 9.1%. The most frequently positive site was the cervix. In this series there was no increased yield by the additional use of the Novak curettage method as compared with obtaining specimens with the platinum loop.
Commentaire de travail de L. Aabakken et al., pp. 1068
Journal: Endoscopy (2007)

See also: Double-balloon enteroscopy for endoscopic retrograde cholangiography in patients with a Roux-en-Y anastomosisEndoscopy 2007; 39(12): 1068-1071DOI: 10.1055/s-2007-966841
Homage to Walter Pagel
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Black-white differences in stroke incidence in a national sample. The contribution of hypertension and diabetes mellitus
Authors: S. J. Kittner
Journal: JAMA (1990)

Although national data have consistently shown an increased risk of death from stroke among blacks, few studies have addressed the reasons for this excess mortality. We compared the incidence of stroke among 1298 blacks and 7814 whites, aged 35 to 74 years, in the 10-year follow-up of the respondents from the First National Health and Nutrition Survey. Blacks had a higher estimated incidence of stroke than whites even after adjustment for age, hypertension, and diabetes mellitus; the relative risk was 1.4 (95% confidence interval, 1.0 to 2.0) for black women and 1.1 (95% confidence interval, 0.8 to 1.6) for black men. The relative risks for stroke associated with hypertension and diabetes mellitus were unrelated to race. Although efforts to treat hypertension and diabetes are among the most important public health measures for reducing stroke, a more complete understanding of the determinants of stroke may be required to account for the excess stroke risk experienced by blacks. (<i>JAMA</i>. 1990;264:1267-1270).
Malpractice Insurance
Authors: R. K. Y. Dusinberre
Journal: JAMA (1975)

<h3>To the Editor.—</h3> The answer to the question in MEDICOLEGAL ROUNDS (230:1453, 1974) concerning malpractice insurance coverage as condition for staff privileges, exemplifies and extends an essentially mercenary principle of medical law noted elsewhere (<i>Am Med News</i>, Feb 12, 1973), which the legal profession seems to lack the inclination or probity to abolish. Quoting the last two sentences of the answer, In most jurisdictions, the courts do not allow disclosure to a jury that a defendant has liability insurance, or the amount of such coverage, but claimants can discover before trial what liability insurance the defendant has. This information may influence the naming of defendants and can be persuasive in deciding whether the hospital or other medical staff members should be joined in the suit when a particular physician on the staff is sued. This means that the plaintiff's lawyer is privileged to select such other staff physicians as codefendants
Acceptability and effects of values-based outpatient advanced care planning (ACP) in gastrointestinal (GI) cancers.
Authors: Andrew S. Epstein, Eileen Mary O'Reilly, Angelo E. Volandes, Yuelin Li, Elyse Shuk, William Breitbart
Journal: Journal of Clinical Oncology (2017)

e21571 Background: We developed and validated the values questions for the Person-Centered Oncologic Care and Choices (P-COCC) ACP intervention, which combines an informational care goals video with a brief patient values interview. Herein, we studied (primarily) the acceptability of P-COCC, and (secondarily) its effects on wellbeing and decisional conflict. Methods: Patients (pts): English-speaking with GI cancer, ≤ monthly followup in MSK medical oncology clinics and believed by their oncologist able to complete study measures and to survive 1-12 months. Consented pts randomized 2:2:1 to P-COCC vs. video alone (V) vs. usual care (UC). Questionnaires: administered baseline and at next follow-up visit on validated measures of wellbeing, and on follow-up only, decisional conflict. P-COCC arm pts also completed 3 Likert scales (was the intervention helpful, comfortable and recommended to others?); a positive score on ≥1 of 3 indicated acceptability for that pt. Results: During screening from 9/2014-11/2016, 202 potentially eligible pts were approached. 51 (25%) declined participation (most common reason, N = 31 = not wanting to discuss the topic). 151 consented and were randomized; 99 (66% of the 151) completed study measures (most common attrition reason, N = 34 = disease progression or death). Of the 99, 63% male; mean age 61 years; mean ECOG PS 1; most common cancer types colorectal, gastroesophageal, and pancreatic; most white race, Christian religion and married. The primary aim was met: Among 33 pts, 32 (97%, 95%CI: 0.84-0.99, p &lt; 0.001) rated P-COCC acceptable. Mean distress scores (0-10) increased (0.43) in the P-COCC arm but decreased in the V (-0.04) and UC (-0.21) arms (p = 0.03 and 0.04, P-COCC vs V and UC, respectively). There were no significant pre-post change scores on other measures of wellbeing (anxiety, depression, stress, acceptance, QOL), or intergroup differences in decisional conflict. Conclusions: Our values-based ACP paradigm is acceptable but may increase distress in GI cancer outpatients. Further studies will investigate underpinnings and follow-up duration of these observations, and ways to best support cancer patients (with any cancers, and regardless of prognosis) in ACP. Clinical trial information: NCT01912131.
New Tissue Culture-Fluorescent Method Speeds Detection of Herpes Simplex Virus
Journal: JAMA (1983)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A 12-Month Follow-Up Study of the Course of Body Dysmorphic Disorder
Authors: Katharine A. Phillips, Maria E. Pagano, William Menard, Robert L. Stout
Journal: American Journal of Psychiatry (2006)

Objective: This study investigated the course of body dysmorphic disorder (BDD), a relatively common and severe disorder, in the first prospective follow-up study, to the authors' knowledge. Method: In this study, the authors obtained data with the Longitudinal Interval Follow-Up Evaluation on weekly BDD symptom status and treatment received over 1 year for 183 broadly ascertained subjects. Probabilities of full remission, partial remission, and relapse during this year were examined. Full remission was defined as minimal or no BDD symptoms and partial remission, as meeting less than full DSM-IV criteria for at least 8 consecutive weeks. Relapse was defined as meeting full BDD criteria for at least 2 consecutive weeks after attaining partial or full remission from BDD. Results: Over 1 year, the probability of full remission from BDD was only 0.09, and the probability of partial remission was 0.21. Although 84.2% of the subjects received mental health treatment during the 1-year period, mean BDD severity scores during the year reflected full DSM-IV criteria for BDD, and the mean proportion of time that the subjects met full BDD criteria was 80%. Gender and ethnicity did not significantly predict remission from BDD. Among the subjects whose BDD symptoms partially or fully remitted, the probability of relapse was 0.15. Conclusions: These findings indicate that BDD tends to be chronic. Remission probabilities were lower than reported for mood disorders, most anxiety disorders, and personality disorders in studies with similar methods.
Affektstörungen.
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diabetes Management
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Thromboembolism after total hip reconstruction. Failure of low doses of heparin in prevention
Authors: C. M. Evarts
Journal: JAMA (1973)

Twenty-five patients undergoing total hip replacement received low doses of heparin sodium. Phlebography was used for the diagnosis of deep venous thrombosis. Five thousand international units (IU) of heparin were given subcutaneously two hours preoperatively, 5,000 IU postoperatively the night of surgery, and every 12 hours for the next seven to ten days. Venous thrombosis developed in seven of 25 patients. Pulmonary embolism occurred in six patients. Until further studies are forthcoming, the utmost caution is urged in the use of low doses of heparin as a prophylactic agent after total hip reconstruction.
Authors' response
Authors: C. Cisneros, F. Garcia-Rio, J. Ancochea
Journal: Thorax (2010)

Thirdly, there are inconsistencies in the data in their figure 2. 1 Seven subjects have PD 20 values close to zero (possibly 0.1 mmol?), and therefore should have DRS values of w200 (ie, 20% fall/0.1 mmol) and CIR values of w2.3 (ie, log 200).These subjects do not appear in figure 2B,C.Furthermore, the distribution of AQLQ differs between figure 2A andB.The advantage of a continuous measure of airway responsiveness such as DRS, rather than PD 20 , is not that DRS provides qualitatively different information but rather that it yields an estimate of airway responsiveness in all subjects, not just the subset with AHR.Airway responsiveness is a continuum, with the cut-off point for AHR defined arbitrarily.However, AHR can be normalised with inhaled corticosteroid therapy, 3 and subjects with asthma can move in and out of the abnormal range.A more appropriate interpretation of the difference between PD 20 and 'reactivity' in their relationships with AQLQ reported by Cisneros et al 1 would be that quality of life is worse in subjects with AHR, but does not worsen with increasing severity of AHR.
Manuscripts Approved for JNCI, September 10 to October 10, 1962
Journal: JNCI Journal of the National Cancer Institute (1962)

Manuscripts Approved for JNCI, September 10 to October 10, 1962 Get access JNCI: Journal of the National Cancer Institute, Volume 29, Issue 5, November 1962, Page 1024, https://doi.org/10.1093/jnci/29.5.1024 Published: 01 November 1962
Computerised updating of clinical summaries.
Journal: BMJ (1989)

stores and that those patients with the greatest aluminium burden had an increased mortality after infection.4As most aluminium given to patients with acute renal failure is taken up by soft tissues, including the liver and spleen, but not by bone' and thus enters the reticuloendothelial system it is not surprising that aluminium may have an immunomodulatory role.Although this may be of benefit to the recipient of a renal transplant, aluminium accumulation should be avoided in patients with acute renal failure, in whom sepsis remains a major cause of both morbidity and mortality.
Social Medicine and Medical Economics
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PLoS Medicine Issue Image | Vol. 2(8) August 2005
Journal: PLoS Medicine (2005)

Emma Burns is a science illustrator who uses traditional and digital media to create images that depict a story or convey meaning with a single glance. A passionate interest in both biology and the arts led her to a combination of the two professions, wherein she creates artwork that reflects the scientific realm. Along with her lifelong interest in art, Emma earned a B.S. in biology. She is fascinated by the natural world, and flora and fauna are commonly found in her illustrations. This image was a concept created to expose the stigma attached to HIV, and how patients are often outcast in society. Having traveled in Africa and worked with AIDS orphans, Emma feels that it is important to use art in helping to define global health issues. Image Credit: Emma Burns (www.emmaillustrations.com)
The Chemistry of the Blood in Clinical Medicine.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nonfunctioning gallbladder and gastric mass
Authors: H. J. Schneider
Journal: JAMA (1975)

<h3>History</h3> A 59-year-old woman was first admitted to the hospital in March 1960 with an acute illness of two days' duration manifested by vomiting and progressive right upper quadrant pain. Blood pressure was 183/100 mm Hg. Tenderness, with a questionable palpable mass, was present in the right upper quadrant. The white blood cell count was 22,500/cu mm with 78% neutrophils. An oral cholecystogram (Fig 1) demonstrated a nonfunctioning gallbladder with large calcifications in the right upper quadrant. An upper gastrointestinal series was normal. The patient responded to conservative management and was discharged. On June 29, 1964, she was readmitted with a four-day history of nausea and vomiting. An upper gastrointestinal series demonstrated incomplete obstruction in the pyloroduodenal region (Fig 2). She again responded rapidly to conservative management and was discharged. On August 6, 1964, she was admitted to the hospital for the third time with an abrupt onset of epigastric