tbuckley/cabot-search huggingface dataset:
SHOCK AS A RESULT OF TOXEMIA
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Therapeutic ultrasound can induce apoptosis in smooth muscle cells: A potential role for restenosis prevention? Uri Rosenschein, Hagit Ashush, Michal Blass, Mira Barda-Saad, Ariella Alter, Frida Firestein, Leon A. Rozenszajn. Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, Bar Ilan University, Ramat Gan, Israel
Journal: Journal of the American College of Cardiology (2001)
TAILOR: A phase III trial comparing erlotinib with docetaxel as the second-line treatment of NSCLC patients with wild-type (wt) EGFR.
Authors: Marina Chiara Garassino, Olga Martelli, Anna Bettini, Irene Floriani, Elena Copreni, Calogero Lauricella, Monica Ganzinelli, Mirko Marabese, Massimo Broggini, Silvio Veronese, Giorgio Gherardi, Flavia Longo, Maria Agnese Fabbri, Maurizio Tomirotti, Oscar Alabiso, Maria Giuseppa Sarobba, Roberto Labianca, Silvia Marsoni, Gabriella Farina, Alberto Scanni
Journal: Journal of Clinical Oncology (2012)

LBA7501 Background: While the benefit of EGFR tyrosine kinase inhibitors in the treatment of patients with NSCLC harboring EGFR mutations has been widely established, their value in treating patients with wt EGFR is still debated. To assess the role of erlotinib in these patients, we performed an independent multicenter phase III trial (Tarceva Italian Lung Optimization Trial [TAILOR] NCT00637910), comparing erlotinib to docetaxel in second line treatment, having overall (OS) and progression free survival (PFS) as principal and secondary endpoints, respectively. Methods: EGFR and KRAS mutational status were assessed by direct sequencing in all eligible patients; only patients with wt EGFR NSCLC (exons 19 and 21) at progression, and previously treated with a first line platinum-based regimen, were randomized to receive either erlotinib 150 mg daily or docetaxel 75 mg/m2 (3-weekly) or 35 mg/m2 (weekly) until disease progression or unacceptable toxicity occurred. To detect an hazard ratio of 0.67 (2-sided 5% significance level for the log-rank test and a power of 80%), 199 events were required for both OS and PFS evaluation. Results: On the planned analysis date (March 30, 2012), 221 patients had been randomized and 218 were evaluable (docetaxel 110, erlotinib 108; three major violations excluded). At a median follow-up of 20 months, 199 relapses and 157 deaths were recorded. The Kaplan-Meier PFS curves showed a highly significant increase favoring docetaxel (HR 0.70 with 95% CI 0.53-0.94; p = 0.016) over erlotinib regimen. The HR translated into an estimated absolute difference in 6-months PFS of 12% (16% vs 28%). Data concerning toxicity were consistent with the literature. Conclusions: In terms of PFS, our results indicate a clear superiority of docetaxel over erlotinib as second line treatment for patients without EGFR mutations in exons 19 or 21. Analysis of OS will be conducted as far as the planned number of 199 deaths is reached.
STUDIES OF THE COLON BACILLUS.—COLON INFECTION OF THE URINARY TRACT.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Interrelationships among Zinc, Copper, Lead, and Cadmium in Food, Feces, and Organs of Humans
Authors: Kenzaburo Tsuchiya, Soichiro Iwao
Journal: Environmental Health Perspectives (1978)

Concentrations of zinc, copper, lead, and cadmium were determined in 20 samples of food collected over a period of 20 days, 221 samples of feces collected over a period of 5 days from 19 males, 17 females, and 11 children and 85 samples each of renal cortex and liver from autopsied human cadavers in order to investigate the relationships among the four metals and among the various martices. In food the highest correlation was observed between copper and zinc (0.34). In feces the highest correlation was also between copper and zinc (0.45). In the highest correlation between cadmium and zinc (0.33), but that in the renal cortex was between copper and cadmium (0.52). These findings suggest that the relationships among the concentrations of the four metals in food and feces are almost equal to each other, but differ greatly from the concentrations in human organs due to the differing metabolic actions of the metals once they are absorbed into the body. In addition, it was observed that zinc and cadmium concentrations in the renal cortex increase with age, but copper and lead concentrations do not show much variation with age.
ATYPICAL NEURODERMATITIS
Authors: A. D. PORTER, H. HABER
Journal: British Journal of Dermatology (1950)

Journal Article ATYPICAL NEURODERMATITIS Get access A. D. PORTER, A. D. PORTER Search for other works by this author on: Oxford Academic Google Scholar H. HABER H. HABER Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 62, Issue 1, 1 January 1950, Pages 25–27, https://doi.org/10.1111/j.1365-2133.1950.tb11111.x Published: 01 January 1950
The influence of market economics on primary health care in Vietnam
Authors: G. A. Gellert
Journal: JAMA (1995)

THE SOCIALIST Republic of Vietnam first cautiously introduced economic reforms in 1986 to reverse the economic deterioration of the previous 15 years. A more extensive and consistent program of reforms, commonly referred to as the introduction of a market economy, began in 1989 as an expression of Vietnamese national policy. The reform programs enacted new monetary, price, and exchange rate policies; tightened credit; decontrolled prices; and abolished or substantially reduced subsidies to state enterprises and consumers as private enterprises emerged. The year 1993 marked a particularly important milestone in the transition to a market economy as Vietnam once again obtained access to concessional international finance.<sup>1</sup> <h3>PRIVATIZATION AND A NEW MARKET ECONOMY</h3> The promise of privatization and market forces in Vietnam, with its industrious and well-educated workforce, should promote socioeconomic development. Sustained economic growth in the range of 8% per year may continue throughout the decade of the 1990s.<sup>1</sup>
One-year follow-up of the phagocytic activity of leukocytes after exposure of rats to asbestos and basalt fibers
Authors: M Hurbánková
Journal: Environmental Health Perspectives (1994)

The phagocytic activity of leukocytes in peripheral blood was investigated after 2, 24, and 48 hr; 1, 2, 4, and 8 weeks; and 6 and 12 months following intraperitoneal administration of asbestos and basalt fibers to Wistar rats.Asbestos and basalt fibers differed in their effects on the parameters stud- ied.Both granulocyte count and phagocytic activity of leukocytes during the 1-year dynamic follow-up in both dust-exposed groups of animals changed in two phases, characterized by the initial stimulation of the acute phase 1, followed by the suppression of the parameters in the chronic phase I1.Exposure to asbestos and basalt fibers led, in phase I1, to impairment of the phagocytic activity of granulocytes.Asbestos fibers also significantly decreased phagocytic activity of monocytes.Exposure to basalt fibers did not affect the phagocytic activity of monocytes in phase 11. Results suggest that the monocytic component of leukocytes plays an important role in the development of diseases caused by exposure to fibrous dusts, but basalt fibers have lesser biological effects than asbestos fibers.-
Cause of death.
Journal: BMJ (1971)

A single theme runs through the 418 pages of the Brodrick report: I greater accuracy in ascertaining the cause of death.The committee spent six years preparing its report, which ranges widely over the history and purpose of coroners and their inquests, death and cremation certificates, treasure trove, and the design of public mortuaries; but time and again it returns to the central principle, that "the main aim of public policy in all the fields which we have reviewed should be to ensure that the cause of every death is de- termined and recorded as accurately as possible."Accurate knowledge of the cause of death is important for two reasons.Firstly, epidemiological and other medical re- search and the early recognition of new hazards to life such as toxic chemicals and industrial diseases all depend on the cause of every death being determined.Secondly, whenever someone dies in circumstances which might cast blame or suspicion on any person or organization the first step in the investigation must be ascertainment of the cause of death.The report argues that the office of coroner is uniquely suited to the role of responsibility for inquiries of both kinds, accepted as it is by the general public as being im- partial and free from pressures of any kind.For most of the public and many doctors, however, reference of a death to a coroner still implies that there is a suspicion that something may have been wrong-a whiff of doubt.If the Brodrick proposals are to work this miscon- ception will need to be dispelled, for the future role of coroner is seen as establishing the cause of death whenever the attending doctor has not got enough information to be reasonably certain of it.The report suggests that in every case the attending doctor's duty should be to see the body to establish that death has occurred, and then to issue a certificate of the fact and cause of death.If he is a fullyregistered practitioner, has attended the dead person at least once in the seven days preceding death, is confident that he can certify the cause of death with accuracy and pre- cision, and there are no grounds for referring the case to the coroner (see summary of these grounds, p. 499) then this certificate is sent to the registrar.The registrar's dis- posal certificate is then authority for cremation or burial.If the attending doctor cannot satisfy all the requirements for certifying the cause of death he is required to send the "fact and cause of death" certificate to the coroner, stating his reasons for referral.Normally he would also report the case by telephone.
3B: H. pylori: Host bacteria interactions
Authors: F Rapisarda ', N Figura, A Granata', E Vasquez', F Fraggetta', S Randone, G Urso, M Bruno, P Fatuzzo, C Gennari, Q Karim, M Worku, R Sidebotham, R Logan ', T Keshavarz, G Rieder, M Hahn, R Hatz ', N Lehn, G Enders, H Nielsen, M Go, A Segura, R Genta, L Andersen, D Graham, S Small, A Dhaenens, F Szczebara, M Husson, M Osato, J Kim, R Gutierrez, M Reddy, D Go, S Barton, S Jordan, V Winrow, P Domizio, D Rampton
Journal: Gut (1996)

Vacuolating toxin (VacA), cytotoxin-associated protein (CagA), urease and heat shock protein (HSP) are important virulence factors of H. pylori(HP).Infection by CagA+ HP is frequently characterised by heavy polymorph infiltration of gastric mucosa.The aim of this study was to investigate whether the severity and the activity of gastritis in patients with chronic renal failure (CRF) were associated with CagA+ HP infection and/or with a particular pattern of antibody response to the infection.A group of 51 patients was studied: 31 patients were on substitutive dialytic treatment (group A), and 20 were on conservative treatment (group B).The infection was diagnosed by histology and Western blotting (WB).Histology was carried out according to the Sydney's system.Serum antibodies to CagA, UreB and HSP were investigated by WB.Results: the prevalence of infec- tion was 76.4%; the prevalence was similar in the two groups; uninfected patients had a certain degree of gastritis activity; infected group B patients had a higher degree of gastritis activity than infected group A patients (P = 0.004); CagA seropositive patients did not have a greater activity of gastritis than CagAM patients (P = 0.540); group B patients with antibodies to UreB had higher degrees of gastritis activity (P < 0.001) and of gastric atrophy (P = 0.038) than group A UreB seropositive patients.These results suggest that, in CRF patients, the uremic microenvironment may interfere with pathogenic mechanisms of HP infection and CagA+ HP infection has no role in activity of gastritis.
AK 局部外用治疗的患者偏好
Authors: D. Kopasker, A. Kwiatkowski, R.N. Matin, C.A. Harwood, F. Ismail, J.T. Lear, J. Thomson, Z. Hasan, G.N. Wali, A. Milligan, L. Crawford, I. Ahmed, H. Duffy, C.M. Proby, P.F. Allanson
Journal: British Journal of Dermatology (2019)

日光性角化病是指多年晒伤导致的粗糙皮肤斑片。AK 斑片可能进展成为一种名为皮肤鳞状细胞癌 (cSCC) 的皮肤癌,但这一变化的风险较低。因此治疗 AK 可能提供有效预防 cSCC 的策略,但这一理论尚未接受严格检测。而且,患者对于 AK 治疗减少皮肤癌这一潜在获益的态度迄今只得到很少关注。AK 治疗包括液氮冷冻(冷冻治疗)、手术切除、乳膏或凝胶等局部外用治疗(5‐氟尿嘧啶、咪喹莫特、巨大戟醇甲基丁烯酸酯凝胶、双氯芬酸和维甲酸)、光动力(光)治疗或激光治疗。这项研究的目的是 (i) 使用离散选择实验 (DCE) 调查患者对于 AK 局部外用治疗的偏好; (ii) 评估患者在临床获益(即,该治疗多有效)和医学负担(例如,不便和不希望的副作用)之间权衡的意愿。为 109 名患者各提供一个选择集合,集合中包括两种假想 AK 局部外用治疗之间的一系列选择和一个“无治疗”自愿退出选择。假想治疗的不同属性与药物负担(治疗强度和时长、局部皮肤反应严重程度、流感样副作用的发生)和治疗疗效(皮肤外观改善和皮肤癌风险降低)相关。此数据的分析很复杂,但结果显示大部分患者已准备好接受较低的皮肤癌风险下降(例如,皮肤癌风险下降 50%,而非下降 60%)和治疗疗效的下降(例如 AK 皮损清除 50%,而非 100% 清除),以减少治疗方案的时间长度和强度以及副作用(包括皮肤炎症和疼痛)。这强调了医生应考虑个体患者偏好,从而改进他们的 AK 治疗态度和提高坚持治疗几率的重要性。
May 17, 2000
Journal: JAMA (2000)

Marcos A. Espinal, MD, DrPH; Sang Jae Kim, ScD; Pedro G. Suarez, MD; Kai Man Kam, MB; Alexander G. Khomenko, MD; Giovanni B. Migliori, MD; Janette Baéz, MD, MPH; Arata Kochi, MD, PhD; Christopher Dye, DPhil; Mario C. Raviglione, MD
H2 antagonists: long-term ulcer therapy?
Authors: W. A. Check
Journal: JAMA (1982)

Accumulated worldwide experience with histamine receptor antagonists (H<sub>2</sub>antagonists), presented at this year's World Congress of Gastroenterology in Stockholm, shows convincingly that these drugs are effective for more than short-term treatment of duodenal ulcer. Both cimetidine and the new, more specific H<sub>2</sub>antagonist ranitidine heal 80% to 90% of both duodenal and gastric ulcers. More important, continuous administration of these agents keeps most ulcers—of both types—healed for at least 12 to 18 months, the longest study periods reported yet. As many as 10% of the population of industrialized countries may suffer either duodenal or gastric ulcer at some time during their lives. So it is not surprising that the first pharmacologically specific H<sub>2</sub>antagonist approved for peptic ulcer, cimetidine, became one of the top two or three best-selling prescription agents in the United States within a few years of its introduction in 1977. It was equally inevitable
Reversal of New-Onset Diabetes through Modulating Inflammation and Stimulating β-Cell Replication in Nonobese Diabetic Mice by a Dipeptidyl Peptidase IV Inhibitor
Authors: Lei Tian, Jie Gao, Jianqiang Hao, Yu Zhang, Huimin Yi, Timothy D. O'Brien, Robert Sorenson, Jian Luo, Zhiguang Guo
Journal: Endocrine Reviews (2010)

Inhibition of dipeptidyl peptidase IV (DPP-IV) activity by NVP-DPP728, a DPP-IV inhibitor, improves the therapeutic efficacy of glucagon-like peptide-1 (GLP-1).CD26 is a membrane-associated glycoprotein with DPP-IV activity and is expressed on lymphocytes.We investigated the effect of NVP-DPP728 on reversing new-onset diabetes in nonobese diabetic (NOD) mice and modulating the inflammatory response and stimulating ␤-cell regeneration.New-onset diabetic NOD mice were treated with NVP-DPP728 for 2, 4, and 6 wk.Blood glucose level was monitored.Regulatory T cells in thymus and secondary lymph nodes, TGF-␤1 and GLP-1 in plasma, and the insulin content in the pancreas were measured.Immunostaining for insulin and bromodeoxyuridine (BrdU) were performed.The correlation of ␤-cell replication with inflammation was determined.In NVP-DPP728-treated NOD mice, diabetes could be reversed in 57, 74, and 73% of mice after 2, 4, and 6 wk treatment, respectively.Insulitis was reduced and the percentage of CD4 ϩ CD25 ϩ FoxP3 ϩ regulatory T cells was increased in treated NOD mice with remission.Plasma TGF-␤1 and GLP-1, the insulin content, and both insulin ϩ and BrdU ϩ ␤-cells in pancreas were also significantly increased.No significant correlations were found between numbers of both insulin ϩ and BrdU ϩ ␤-cells in islets and ␤-cell area or islets with different insulitis score in NOD mice with remission of diabetes.In conclusion, NVP-DPP728 treatment can reverse new-onset diabetes in NOD mice by reducing insulitis, increasing CD4 ϩ CD25 ϩ FoxP3 ϩ regulatory T cells, and stimulating ␤-cell replication.␤-Cell replication is not associated with the degree of inflammation in NVP-DPP728-treated NOD mice.
Maternal Diet Affects Mutant Gene Expression
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Poster Session 4
Authors: M Bougiakli, ; Giannitsi, ; Bechlioulis, ; Gkirdis, ; Kotsia, ; Lakkas, ; Antoniou, ; Katsouras, L Michalis, K Naka, K Salah, Wem Kok, Lwm Eurlings, ; Metra, ; Stienen, Jgp Tijssen, Y Pinto, S Giannitsi, ; Bougiakli, ; Pappas, S Binno, ; Tedeschi, ; Luppi, ; Poli, ; Coghi, ; Piepoli, ; Cabassi, Yyuya Matsue, M Suzuki, A Matsumura, Y Hashimoto, J Krzysztofik, ; Sokolski, ; Lis, ; Klepuszewski, ; Kasperczyk, ; Proniak, ; Kowalski, ; Banasiak, ; Ponikowski, E Jankowska
Journal: European Journal of Heart Failure (2014)
Tuberculosis
Authors: Karen R. Jacobson
Journal: Annals of Internal Medicine (2017)

This issue provides a clinical overview of tuberculosis, focusing on screening, prevention, diagnosis, and treatment. The content of In the Clinic is drawn from the clinical information and education resources of the American College of Physicians (ACP), including MKSAP (Medical Knowledge and Self-Assessment Program). Annals of Internal Medicine editors develop In the Clinic in collaboration with the ACP's Medical Education and Publishing divisions and with the assistance of additional science writers and physician writers.
Molecular level view gives immune system clues
Authors: C. Marwick
Journal: JAMA (1985)

As investigators, seeking clues to the causes of the acquired immunodeficiency syndrome (AIDS), have delved ever deeper into arcane aspects of the immunopathology involved, many of them have been struck by an apparent paradox: How can there be such a selective defect in AIDS and yet at the same time be such a broad spectrum of heterogeneous abnormalities? Speaking at the International Conference on AIDS in Atlanta, the head of a group of pioneer investigators into the immunology of AIDS, Anthony S. Fauci, MD, of the National Institutes of Health, Bethesda, Md, posed this question to his audience. In the process of answering it, he provided a look at some new findings on the abnormal functioning of the immune system in AIDS. Fauci is director of the National Institute of Allergy and Infectious Diseases. Despite his administrative responsibilities, which he assumed last November, Fauci spends a considerable portion of his
89P Questionnaire survey on patients’ preference for orally disintegrating tablets or granules of S-1 in postoperative adjuvant treatment for breast cancer
Authors: I. Fukada, Y. Ito, T. Shibayama, K. Kobayashi, N. Teruya, S. Takahashi, R. Horii, F. Akiyama, T. Iwase, M. Toi, S. Ohno
Journal: Annals of Oncology (2016)
Stein-Bockenheim
Authors: Gregory D. Curfman
Journal: JAMA (1990)

During my childhood I was only dimly aware of my family's German heritage. I was born in the United States less than two years after the end of Hitler's war, and my grandfather once mentioned that we were of German descent. My American-born father, a US Navy officer during the Second World War, never brought up the subject. At that time, an ancestral link to Germany was not considered altogether respectable. Although my family's religious affiliation was Protestant, I attended grade school with a preponderance of Jewish children from a neighboring community. With my unmistakably Teutonic surname and shock of blond hair, I stood out from my darker-haired classmates, but nevertheless I had many friends and was enriched by their traditions, religion, and culture. Little by little, my closest friends virtually adopted me into their families. At that young age, we had only the faintest perception that not long before,