tbuckley/cabot-search huggingface dataset:
Regional Variation in Diabetes Mellitus Prevalence—United States, 1988 and 1989
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Plasma homocysteine as a risk factor for vascular disease. The European Concerted Action Project
Authors: I. M. Graham
Journal: JAMA (1997)

Context.-Elevated plasma homocysteine is a known risk factor for atheroscle rotic vascular disease, but the strength of the relationship and the interaction of plasma homocysteine with other risk factors are unclear.Objective.-Toestablish the magnitude of the vascular disease risk associated with an increased plasma homocysteine level and to examine interaction effects between elevated plasma homocysteine level and conventional risk factors.Design.-Case-controlstudy.Setting.-Nineteencenters in 9 European countries.Patients.-Atotal of 750 cases of atherosclerotic vascular disease (cardiac, ce rebral, and peripheral) and 800 controls of both sexes younger than 60 years.Measurements.-Plasmatotal homocysteine was measured while subjects were fasting and after a standardized methionine-loading test, which involves the administration of 100 mg of methionine per kilogram and stresses the metabolic pathway responsible for the irreversible degradation of homocysteine.Plasma cobalamin, pyridoxal 5'-phosphate, red blood cell folate, serum cholesterol, smoking, and blood pressure were also measured.Results.-The relative risk for vascular disease in the top fifth compared with the bottom four fifths of the control fasting total homocysteine distribution was 2.2 (95% confidence interval, 1.6-2.9).Methionine loading identified an additional 27% of atrisk cases.A dose-response effect was noted between total homocysteine level and risk.The risk was similar to and independent of that of other risk factors, but Inter action effects were noted between homocysteine and these risk factors; for both sexes combined, an increased fasting homocysteine level showed a more than multiplicative effect on risk in smokers and in hypertensive subjects.Red blood cell foiate, cobalamin, and pyridoxal phosphate, all of which modulate homocysteine metabolism, were inversely related to total homocysteine levels.Compared with nonusers of vitamin supplements, the small number of subjects taking such vita mins appeared to have a substantially lower risk of vascular disease, a proportion of which was attributable to lower plasma homocysteine levels.Conclusions.-Anincreased plasma total homocysteine level confers an Inde pendent risk of vascular disease similar to that of smoking or hyperlipidemia.it powerfully increases the risk associated with smoking and hypertension.It is time to undertake randomized controlled trials of the effect of vitamins that reduce plasma homocysteine levels on vascular disease risk.
The Diagnosis of Alzheimer-Type Dementia
Authors: Robert P. Friedland, Thomas F. Budinger, Michael Brant-Zawadzki, William J. Jagust
Journal: JAMA (1984)

DESPITE recent advances in our understanding of the pathophysiology of Alzheimer's disease (AD), we remain unable to make the diagnosis noninvasively, except by exclusion. While computed tomography (CT) is of great value in indicating the absence of other dementing illnesses, it cannot be relied on to confirm the diagnosis of AD. The cortical and ventricular atrophy present in AD is not apparent in all cases and often cannot be distinguished from the changes on CT in healthy, aged persons.<sup>1</sup>The more recently developed technique of positron emission tomography (PET) has been used with a labeled glucose analogue (<sup>18</sup>F)-2-fluoro-2-deoxy-D-glucose (FDG) to study glucose metabolism in dementia non-invasively. Specific regional alterations, particularly in the temporalparietal cortex, have been found.<sup>2-5</sup>Magnetic resonance (MR) imaging is another powerful new technology that is beginning to be applied to dementia. In this report we present a comparison of the findings in PET-FDG studies
Abstract 2980: Long-term Outcome Of Unprotected Left Main Coronary Artery Stenting With Drug-eluting Stent: Comparison With Bare-metal Stent
Authors: Young-Hak Kim, Duk-Woo Park, Seung-Whan Lee, Jeong-Soon Kim, Hyo-Jung Nam, Jong-Young Kim, Gyung-Jung Kim, Cheol Whan Lee, Myeong-Ki Hong, Jae-Joong Kim, Seong-Wook Park, Seung-Jung Park
Journal: Circulation (2007)

Background: Long-term outcome of drug-eluting stent (DES) implantation for unprotected left main coronary artery stenosis has not been evaluated in detail. Methods: This study included 226 patients with de novo coronary lesions at the unprotected left main coronary artery (ULMCA) who were electively treated with DES and eligible for 2-year follow-up. The outcomes of these patients were compared with those of 200 patients treated with bare-metal stent (BMS) in the preceding years using log-rank test. Cox proportional hazard regression analyses were performed to correct for independent predictors of adverse outcomes between the two groups. Results: The DES patients were older, had more history of hypertension and diabetes mellitus, had more involvement of right coronary artery and three vessel stenoses, and were treated with more stents and longer stented length than the BMS patients. On the other hand, debulking atherectomy were more frequently used in the BMS patients. Two-year outcomes with adjusted hazard ratios are presented in the table . Conclusions: For ULMCA stenosis, the superiority of DES in reducing target lesion revascularization (TLR) rate compared with BMS was continuously present up to 2 years. Furthermore, DES had a trend towards lower incidences of death, cardiac death, and stent thrombosis compared with BMS.
PARATYPHOID.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Structure And Function Of Human And Murine Receptors For IgG
Authors: J. Unkeless
Journal: Annual Review of Immunology (1988)

Structure and Function of Human and Murine Receptors for IgG, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/immunol/6/1/annurev.iy.06.040188.001343-1.gif
Metabolism of the Food-Borne Carcinogens 2-Amino-3-Methylimidazo-[4,5-f]quinoline and 2-Amino-3,8-Dimethylimidazo[4,5-f]-Quinoxaline in the Rat As a Model for Human Biomonitoring
Authors: Robert J. Turesky, W. G. Sara Stillwell, Paul L. Skipper, Steven R. Tannenbaum
Journal: Environmental Health Perspectives (1993)
Cardiology and the quality of medical practice. The Cardiology Working Group
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prescription Restriction
Authors: Eben Alexander
Journal: JAMA (1974)

<h3>To the Editor.—</h3> At first, one is amused by an extremely well written letter. The feeling of humor is supplanted by a feeling of dread, for it is apparent that a great deal is happening to us in the restrictions on the medical profession in the care of patients. Just how this can be stopped is difficult to say, but we should all write to our representatives in the Senate and the Congress to let them know of our concern, since they are just as much a part of this as we are.
Conflicts of interest. Physician ownership of medical facilities. Council on Ethical and Judicial Affairs, American Medical Association
Authors: Oscar W. Clarke, John Glasson, Allison M. August, John A. Barrasso, Charles H. Epps, Robert McQuillan, Charles W. Plows, Michael A. Puzak, George T. Wilkins, David Orentlicher, Kristen A. Halkola, Kirk B. Johnson, Robert B. Conley
Journal: JAMA (1992)

In this report, the Council on Ethical and Judicial Affairs revisits the question of referral of patients to medical facilities in which physicians have financial interests ("self-referral"). The Council issued safeguards in 1986 to prevent abuses of self-referral and most recently updated the guidelines in 1989. Recent studies, however, have suggested that problems with self-referral persist; these problems undermine the commitment of physicians to professionalism. The Council has concluded that, in general, physicians should not refer patients to a health care facility outside their office practice at which they do not directly provide care or services when they have an investment interest in the facility. Physicians may invest in and refer to an outside facility if there is a demonstrated need in the community for the facility and alternative financing is not available.
Peripatetic Plague
Authors: Jonathan M. Mann
Journal: JAMA (1982)

Cases of plague continue to occur in various parts of the world, including the western United States, where plague is endemic among the wild rodent population. In 1980, a case of plague acquired in New Mexico and hospitalized in Nebraska illustrated the problem of plague occurring in persons traveling from the state in which they become infected to another state. Nine cases of plague in travelers were identified among the 166 cases of plague reported in the United States from 1950 to 1980. Physicians should be aware of natural plague foci in the western United States and should obtain a travel history from patients with an illness clinically compatible with plague. (<i>JAMA</i>1982;247:47-48)
PLEXIFORM NEUROFIBROMA.
Authors: FRANK B. WYNN
Journal: JAMA (1906)

The plexiform type of neurofibroma is considered by Recklinghausen, Kyrieleis, Kriege, Hurthle, Teichert, Westphalen and others to arise invariably from the connective tissue of nerve trunks. In opposition to this view, Lahmann maintains that such neoplasms may not only originate in the connective tissue of the nerve trunks, but also from that of the blood vessels or of the skin glands or hair follicles as well. His findings have been corroborated in whole or in part by Philippson, Du Mesnil, Verneuil and Löwenstein. Bearing on this mooted question, the following case may present some features of interest: <h3>Family and Personal History.</h3> —R. E., the unfortunate subject of this report (Fig. 1), is aged 19 years. His parents, live brothers and two sisters are living and healthy. There is no hereditary taint. His training in an institute for the blind was thorough, and, all things considered, he is exceptionally bright and
Poor Children Subject to "Environmental Injustice"
Authors: M. J. Friedrich
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Management of cancer pain with parenteral medication
Authors: W. T. Beaver
Journal: JAMA (1980)

ANALGESICS are most effective in the management of cancer pain when incorporated into a comprehensive regimen of total patient care. Such a regimen includes specific therapy for the cause of pain, which may be the cancer itself, some painful complication, or a nonmalignant intercurrent illness. Measures to decrease other sources of distress and improve the patient's general emotional state are also of great importance. Oral analgesics or analgesic combinations should, when possible, be used in the management of chronic cancer pain.<sup>1,2</sup>Oral analgesic administration offers simplicity and economy, avoids the discomforts and potential complications of repeated injections, makes the patient less dependent on others for his care, and may even obviate the need for hospitalization in some cases. Parenteral administration is most often necessitated by the patient's inability to swallow or retain oral medication. Physicians also frequently resort to parenteral analgesics because of the apparent failure of oral medications
Endocrine Pathology
Authors: Nelson R. Niles
Journal: JAMA (1969)

Bloodworth has blended into a scholarly, attractive volume 18 chapters about the pathology of endocrinologic diseases. In spite of the complexity and restlessness of this field, the organization is complete and virtually avoids repetition. No similar publication exists. The price is high but worth it. The book will principally serve general pathologists, who will find much value here; it may contain more detail than seems desirable, but the effort, either in writing or reading, will not be wasted. Many clinicians and investigators should also strike gold. The author stresses pathologic physiology and handles it well. Morbid anatomy is presented adequately but without the detail found in Armed Forces Institute of Pathology fascicles. The chapter on mechanisms of hormone action outlines, in deceptively simple form, some basic principles; this area is only beginning to expand but biochemistry must eventually become the basis of endocrinology. The classic endocrine glands receive thorough coverage.
DRAMS scheme
Authors: R. Earwicker, T. Wolff
Journal: BMJ (1991)

The clinical course of nine cystic fibrosis patients homozygous for the CF gene nonsense mutation R1162X was investigated. Since this mutation should lead to an interruption in the synthesis of the cystic fibrosis transmembrane regulator (CFTR) protein, a severe clinical course was expected. All patients showed pancreatic insufficiency, while the course of the lung disease was mild to moderate. These results suggest that this form of truncated CFTR protein, still containing the regulatory region, the first ATP binding domain, and both transmembrane domains, could be partially working in the lung tissues.
ASSOCIATION NEWS.
Authors: H. V. Wurdemann
Journal: JAMA (1895)

<h3>Section on Ophthalmology.—Report of the Secretary.</h3> Place of meeting, gentlemen's reception room, Music Hall. Meeting called to order at 3:30 P.M., by the chairman, Edward Jackson, of Philadelphia, Pa., who delivered the Annual Address, "The Strength of the Different Mydriatics and Myoptics." At the close of the address a resolution was passed limiting time for reading of papers to ten minutes and discussion to five minutes for each speaker. A. R. Baker, of Cleveland, Ohio, read a paper on "Incipient Cataract," followed by J. E. Weeks, of New York, with "The Operative Treatment of Immature and Some Forms of Zonular Cataract." The discussion on these papers was opened by Geo. E. Frothingham, of Detroit, Mich., followed by Herman Knapp, of New York; Joseph A. White, of Richmond; J. L. Thompson, of Indianapolis; Jas. A. Lydston, of Chicago; F. C. Hotz, of Chicago; S. D. Risley, of Philadelphia; A. J. Erwin,
Inhibition of ? 24-dehydrocholesterol reductase ameliorates non-alcoholic steatohepatitis in mice
Authors: Hiroyuki Nakashima, Enchen Zhou, Patrick van der Zande, Zhuang Li, Evelyne Steenvoorden, Christoph Müller, Martin Giera, Bruno Guigas, Franz Bracher, Patrick Rensen, Yanan Wang
Journal: Journal of Hepatology (2020)
Medical Economics
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
METB-10DELINEATING INTRA-TUMOUR METABOLOMIC AND PHOSPHO-PROTEOMIC HETEROGENEITY IN PATIENT GLIOBLASTOMAS THROUGH ADVANCED ANALYTICAL METHODS
Authors: James Wood, Dong-Hyun Kim, David Tooth, Martin Wilson, Jennifer Ward, Christopher Bennett, Anbarasu Lourdusamy, Andrew Peet, Robert Layfield, David Barrett, Stuart Smith, Ruman Rahman
Journal: Neuro-Oncology (2015)
Comparison of prophylactic clip and endoloop application for the prevention of postpolypectomy bleeding in pedunculated colonic polyps: a prospective, randomized, multicenter study
Authors: Jeong-Seon Ji, Seung-Woo Lee, Tae Kim, Young-Seok Cho, Hyung-Keun Kim, Kang-Moon Lee, Sang-Woo Kim, Hwang Choi
Journal: Endoscopy (2014)

Correction to: Comparison of prophylactic clip and endoloop application for the prevention of postpolypectomy bleeding in pedunculated colonic polyps: a prospective, randomized, multicenter studyEndoscopy 2014; 46(07): 598-604DOI: 10.1055/s-0034-1365515
Renal Carcinoma
Authors: Richard L. Reece
Journal: JAMA (1967)

I can best characterize<i>Renal Carcinoma</i>by separately considering its text, its illustrations, and its references. Before describing in words any of these parts, I shall cite some numbers. Of the book's 258 pages (index excluded), the text takes up 34% of the space, the references 12%, and the illustrations 54%. These figures reveal what kind of book this is—a richly illustrated, carefully documented monograph. Now, a few words about the writing. In their preface, the authors, a pathologist at Kings County Hospital in Seattle and a surgeon at Kaiser Foundation Hospital in Oakland, Calif, say that "personal frustration" over finding reliable information on kidney carcinoma moved them to write. To ease this frustration, they reviewed pathological material at their institutions, scoured the literature, grouped their siftings in tables, and set down what they learned from others. I say "others" because the authors never really come to grips with their
Hepatocellular thyroid hormone efflux is a novel mechanism for regulation of thyroid hormone action Metabolic Research Unit and Liver Center, Univ. of CA, San Francisco 94143
Journal: Hepatology (1995)

Polycystic liver disease (PLD) is a member of the cholangiopathies, a group of liver diseases in which cholangiocytes, the epithelia lining of the biliary tree, are the target cells. PLDs are caused by mutations in genes involved in intracellular signaling pathways, cell cycle regulation, and ciliogenesis, among others. We previously showed that cystic cholangiocytes have abnormal cell cycle profiles and malfunctioning cilia. Because histone deacetylase 6 (HDAC6) plays an important role in both cell cycle regulation and ciliary disassembly, we examined the role of HDAC6 in hepatic cystogenesis. HDAC6 protein was increased sixfold in cystic liver tissue and in cultured cholangiocytes isolated from both PCK rats (an animal model of PLD) and humans with PLD. Furthermore, pharmacological inhibition of HDAC6 by Tubastatin-A, Tubacin, and ACY-1215 decreased proliferation of cystic cholangiocytes in a dose- and time-dependent manner, and inhibited cyst growth in three-dimensional cultures. Importantly, ACY-1215 administered to PCK rats diminished liver cyst development and fibrosis. In summary, we show that HDAC6 is overexpressed in cystic cholangiocytes both in vitro and in vivo, and its pharmacological inhibition reduces cholangiocyte proliferation and cyst growth. These data suggest that HDAC6 may represent a potential novel therapeutic target for cases of PLD.