tbuckley/cabot-search huggingface dataset:
Lectures on the Diseases of Children: Delivered in the Chatham Street School of Medicine, Manchester
Authors: None Merei
Journal: BMJ (1852)

Treatment of continued fever in its hypersthenic and asthenic stages.-Localaffections (apparently inflam- matory) which arise in the hypersthenic stage, require moderation in the use of debilitating means; thefever itself, uncomplicated, if present in infants, requires a 'bland and expectant management, in spite of high hypers henic symptoms.Above that age some reme.dies admissible.Sponging with cold water.I'wo asthenic forms, and their treatment.Cimplicationsdiarrhcsa, and angina; treatment.GENTLEMEN,-Having to speak at present of the treatment of continued fever in its hypersthenic and asthenic stages, I beg you to remember the principles mentioned when we spoke of the management of con- tinued fever within the first day or two.You will continue to follow, with a vigilant eye, the state of the head, throat, and abdomen, and combat local affections and complications, if there are any.A degree of erythematous angina is not unfrequent at that stage.But, although the hypersthenic symptoms may appear high and tumultuous, let me recommend moderation in the use of active reinedies against local affections, par- ticularly in leeching and the employment of the emetic.We must pay attention to this.That kind of local affection which may appear as inflammatory, showing itself under very high temperature, and dryness of the skin, with the pulse above 160, does not admit of such powerful antiphlogistic treatment, as if the same local affection had appeared in the form of primar.yinflam- mation, under less heat, dryness, and frequency of the pulse.The passage to asthenia, in this case and age, is too easy, and may be precipitated by even a moderate loss of blood.Thus, too, if signs of angina should appear about the third day of the fever, under the described hypersthenic symptoms, there is scarcely any good chance for the emetic, unless the constitution of the child aud its age, be particularly encouraging.Bilious discharges must rather be gently promoted, never directly stopped bv astringents, and the general bilious tint, particularly in hot summer time, counteracted by tartaric or citric acid, in solution.But if there is no salient complication, and the child be of tender age, the management must be rather abstemious from medicine.The usual way of practice in these cases, is to prescribe some saline, antimonial, or other kind ot active remedy, calomel not excepted.This practice is intended to break the violence of vascular action, cool the blood No.
Author Names Misspelled
Authors: Nicholas Mordwinkin, Andrew Lee, Joseph Wu
Journal: JAMA (2014)

Djillali Annane, MD, PhD; Shidasp Siami, MD; Samir Jaber, MD, PhD; Claude Martin, MD, PhD; Souheil Elatrous, MD; Adrien Descorps Declère, MD; Jean Charles Preiser, MD; Hervé Outin, MD; Gilles Troché, MD; Claire Charpentier, MD; Jean Louis Trouillet, MD; Antoine Kimmoun, MD; Xavier Forceville, MD, PhD; Michael Darmon, MD; Olivier Lesur, MD, PhD; Jean Reignier, MD; Fékri Abroug, MD; Philippe Berger, MD; Christophe Clec’h, MD, PhD; Joël Cousson, MD; Laure Thibault, MD; Sylvie Chevret, MD, PhD; for the CRISTAL Investigators
Clinical perspectives on seabather's eruption, also known as 'sea lice'
Authors: R. S. Tomchik
Journal: JAMA (1993)

Seabather's eruption is usually a benign clinical syndrome that resolves spontaneously, although severe symptoms and long-term sequelae have been identified. Recent research has implicated the larvae of a jellyfish,<i>Linuche unguiculata</i>, as the cause of this syndrome; confirmation by serological and experimental studies is pending. Clinical signs and symptoms are consistent with this etiology. Outbreaks occur when jellyfish larvae are transported to shore by ocean currents. Treatment is symptomatic and involves use of antihistamines and steroids. (<i>JAMA</i>. 1993;269:1669-1672)
Nutrition.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The PBDEs: An Emerging Environmental Challenge and Another Reason for Breast-Milk Monitoring Programs
Authors: Kim Hooper, Thomas A. McDonald
Journal: Environmental Health Perspectives (2000)

Levels of the polybrominated diphenyl ethers (PBDEs), a class of widely used flame retardants, appear to be rising rapidly in human tissues, as evidenced by studies of human breast milk. The case of the PBDEs illustrates the value of breast-milk monitoring programs in identifying important emerging pollutants, and highlights why such monitoring programs are needed in the United States. A review of the use, occurrence, and toxicity of PBDEs indicates many parallels between some PBDEs, PCBs, and other polyhalogenated persistent organic pollutants, and suggests that the PBDEs may be a significant environmental challenge in the future.
CORRECTIONS
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Relation of Mastocytosis and Lymphomatous Disease.
Authors: R. K. Nixon
Journal: Annals of Internal Medicine (1965)

s1 November 1965The Relation of Mastocytosis and Lymphomatous Disease.R. K. Nixon, M.D.R. K. Nixon, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-5-912_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn a recent study we have determined a frequent A association of marrow mastocytosis with lymphocytic dyscrasias. Although increases in mast cells have been encountered occasionally with lymphocytoses in other diseases (miliary tuberculosis, locally invasive carcinoma), only in urticaria pigmentosa has a corresponding degree of mastocytosis been observed. Moderate marrow mast cell increases are found in the areas of normal lymph follicles.A more impressive demonstration of this association of mast cell and lymphocytic disease has been displayed in two of our patients. The first presented with episodic flushing, urticaria pigmentosa, adenopathy, and hepatosplenomegaly. Laboratory data included marrow mastocytosis and... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Detroit, Michigan PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1965Volume 63, Issue 5Page: 912-913KeywordsBone marrowHepatosplenomegalyLymphMast cellsMastocytosisMiliary tuberculosisResearch laboratoriesUrticaria Issue Published: 1 November 1965 PDF DownloadLoading ...
Prevalence of Self-Reported Epilepsy— United States, 1986-1990
Journal: JAMA (1994)

Epilepsy is a chronic neurologic condition characterized by abnormal electrical discharges in the brain manifested as two or more unprovoked seizures (1). Risk factors for epilepsy include vascular disease, head trauma, congenital or perinatal factors, central nervous system infections, and neoplasms; however, the etiology of epilepsy is unknown for approximately three fourths of cases (2). Epilepsy frequently causes impaired physical, psychological, and social functioning, which results in substantial disability, economic loss, and diminished quality of life (3). To examine the burden of epilepsy in the United States, the prevalence of self-reported epilepsy was estimated by using data from 1986 through 1990 from the National Health Interview Survey (NHIS) (4). This report summarizes the results of this analysis.
Adrenal structure and function in advanced carcinoma of the breast. II. The relation of steroid excretion to adrenal morphology and the outcome of adrenalectomy, with description of a new discriminant function
Authors: R. E. Wilson
Journal: JAMA (1967)

Variations in palliative response of breast cancer to adrenalectomy can be explained either by variations in the glands removed, by variations in the biology of the neoplasm, or by variations in the host herself. Most of the reported studies of this subject have been devoted to the latter two concepts; seeking to discern either in the tumor (the anatomy of its metastases, its growth rate), or in some aspect of the host (the free interval, age, or menopausal status) some indicator of the anticipated response. Recently, attention has been devoted to the urinary hormone excretion as a measure of adrenal function, and subsequent derivation from that information of a discriminant or predictor of clinical response. A previous report compared the extent of adrenal atrophy observed after prolonged corticosteroid treatment with that observed following hypophysectomy in patients with advanced carcinoma of the breast.<sup>1</sup>Hypophysectomy produced a far more profound adrenal
BOOK REVIEWS
Authors: H. ROTHBERG
Journal: JNCI Journal of the National Cancer Institute (1988)

Journal Article BOOK REVIEWS Get access Diagnosis and Management of Metastatic Bone Disease: A Multidisciplinary Approach. Franklin H. Sim, ed. New York: Raven Press, 1988, 372 pp. $85. HARVEY ROTHBERG HARVEY ROTHBERG Princeton Medical Center, Medical Arts Bldg.Suite B 253 Witherspoon St. Princeton, NJ 08540 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 80, Issue 9, 6 July 1988, Pages 696–697, https://doi.org/10.1093/jnci/80.9.696-a Published: 06 July 1988
Archiv und Atlas der normalen und pathologischen Anatomie in typischen Röntgenbildern. Die Wirbelsäulenverletzungen und ihre Ausheilung: Experimentelle, pathologisch-anatomische und röntgenologisch-klinische Untersuchungen
Journal: JAMA (1941)

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Health System Ethics
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Quantitative detection of hepatitis C virus RNA with a solid-phase signal amplification method: Definition of optimal conditions for specimen collection and clinical application in interferon-treated patients
Authors: G Davis
Journal: Hepatology (1994)

To determine the optimal conditions for preparation of serum specimens for quantitative hepatitis C virus RNA determination, patient samples were processed such that differences in time from clot formation to centrifugation, centrifugation to separation of serum and collection of serum until freezing could be independently assessed. The effects of multiple cycles of freezing and thawing were also determined. There was progressive and significant loss of hepatitis C virus RNA activity when the time from the formation of the clot until centrifugation was longer than 2 hr. This reduction reached 32% after 6 hr and 49% after 24 hr. If centrifugation was performed immediately after formation of the clot, loss of hepatitis C virus RNA activity was reduced to less than 10% even though the serum remained unseparated from the clot for up to 6 hr. Centrifugation of blood through a paraffin plug (serum separator tube) prevented loss of hepatitis C virus RNA activity for up to 24 hr. There was no loss of hepatitis C virus RNA activity with up to three freeze-thaw cycles. When patient specimens were prepared under these optimal conditions, the sensitivity of the quantitative branched DNA signal amplification assay in patients with hepatitis C virus infection was 83% and the specificity in patients with liver disease was 100%. Fluctuations in hepatitis C virus RNA levels were shown to correlate with biochemical changes observed in patients treated with recombinant inter-feron-α2b. These data demonstrate that improper or inconsistent methods of serum preparation may result in falsely low and unreliable levels of hepatitis C virus RNA. Clinical applications of quantitative hepatitis C virus RNA assays will only be possible when sera are properly prepared. (HEPATOLOGY 1994;19:1337–1341.)
THE "DIVINE DIPLOMA."
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The involucrin gene of Old-World monkeys and other higher primates: synapomorphies and parallelisms resulting from the same gene-altering mechanism.
Authors: Philippe Djian, Howard Green, M Fasciculatia Clone, M Mulatta
Journal: Molecular Biology and Evolution (1992)

The involucrin gene of platyrrhines and hominoids contains a segment of 10-codon repeats which were added vectorially at the same site in the coding region. We have now cloned and sequenced the involucrin gene of four cercopithecoid monkeys--two macaques (mulatta and fascicularis) and two Cercopithecus monkeys (aethiops and hamlyni). Each gene contains a similar segment of short repeats; some of these were added in a common anthropoid lineage, others were added in a common catarrhine lineage, and still others were added in a common macaque or Cercopithecus lineage. Repeats added before a lineage diverges become synapomorphies in the sister taxa resulting from the divergence. Repeats added independently in different diverged lineages become parallelisms. The synapomorphies are the result of the action of a targeted duplication mechanism acting in a common ancestral lineage, but the parallelisms are the result of the same duplication mechanism transmitted to successively divergent sublineages and acting independently in each.
Committee on rating of mental and physical impairment: the skin
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 11791: Blockade of Senescence-associated Microrna-195 in Aged Skeletal Myoblasts Facilitates Reprogramming to Produce Induced Pluripotent Stem Cells
Authors: Hideyuki Kondo, Ha Won Kim, Lei Wang, Motoi Okada, Ronald W Millard, Tohru Masuyama, Yigang Wang
Journal: Circulation (2015)

Background: Older age is the major risk factor for heart failure, and reprogramming a patient’s own cells to produce induced pluripotent stem cells (iPSCs) is a promising strategy for autologous cell transplantation therapy. However, low reprogramming efficiency of senescent cells remains as a major pitfall. Recently, our preliminary data suggested that inhibiting senescence-associated miR-195 rejuvenated aged stem cells by reactivating anti-aging defense system. This study investigated the effects of blocking miR-195 expression on the reprogramming efficiency of old skeletal myoblasts (OSkMs). Methods and Results: MiR-195 expression was significantly higher in OSkMs isolated from aged mice (24 months) as compared to those from young mice (2 months), as examined by RT-PCR. OSkMs showed impaired expression of anti-aging factors (Tert and Sirt1) and higher expression of pro-aging markers (p53, p21, p16). Intriguingly, blocking miR-195 expression in OSkMs by transfection with anti-miR-195 significantly induced restoration of Tert and Sirt1 as well as telomere re-lengthening as examined by RT-PCR and quantitative fluorescent in situ hybridization. Luciferase assay confirmed that Sirt1 is one of the direct targets of miR-195 relevant to senescence of OSkMs. Importantly, lower reprogramming efficiency of OSkMs was significantly improved by miR-195 abrogation without altering karyotype or expression of pluripotency markers. Furthermore, iPSCs lacking miR-195 successfully differentiated into all three germ layers, indicating that deletion of miR-195 does not affect pluripotency. Notably, contraction rates were markedly higher in beating cells transfected with anti-miR-195 as compared to that with scramble (68.5±5.6 vs 47.3±2.8/min). Conclusions: Blocking age-induced miR-195 is a novel promising approach for efficient iPSCs generation from senescent cells, which has beneficial for autologous transplantation of iPSCs in elderly patients.
Smallpox Vaccination
Authors: J. Michael Lane
Journal: JAMA (1977)

OLD IDEAS die hard. For more than a century and a half, the medical and public health professions have Vigorously promoted smallpox vaccination. "Antivaccinator" became synonymous with anti-intellectual. Patients ask us, "I was vaccinated, my children were vaccinated, all my family have been vaccinated; why aren't you vaccinating my grandchildren?" We have dropped smallpox vaccination just when the media have been criticizing the medical profession for lack of attention to preventive medicine. Some patients, and indeed some of our medical colleagues, do not understand the rationale behind cessation of routine smallpox vaccination. <b>Where does smallpox come from?</b>While most patients understand the concept of infection or contagiousness, they frequently have not thought in terms of the source or reservoir of infectious agents. Although smallpox virus can be found for a short time in scabs and bedding from patients, for practical purposes infection results only from contact with patients in the
PANIMMUNITY
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal