tbuckley/cabot-search huggingface dataset:
Abstract 16420: The E3 Ubiquitin Ligase is Upregulated During Cardiac Hypertrophy
Authors: Wassim A Basheer, Robert L Price, Francis G Spinale, Lydia E Matesic
Journal: Circulation (2015)

Introduction: Cardiomyocyte hypertrophy is observed during normal postnatal cardiac development as well as during disease-related cardiac remodeling. This growth is accompanied by dynamic changes at the intercalated disc, including the redistribution and degradation of the gap junction protein connexin 43 (Cx43). We have shown that the ubiquitin ligase Wwp1 can promote the degradation of Cx43, and that genetic upregulation of Wwp1 stimulates hypertrophy and arrhythmogenesis. Hypothesis: We hypothesized that changes in the expression of Wwp1 would be associated with developmental and pathological hypertrophy programs. Methods: Expression of Wwp1 was analyzed by digital droplet PCR in hearts derived from normally developing mice at 2, 4, 6, and 8 weeks of age (n=6 for each) or from adult mice subjected to transverse aortic constriction (n=5) vs. sham operated animals (n=5). Cardiac structure and function of mice overexpressing or lacking expression of Wwp1 was evaluated by transmission electron microscopy (n=3) and echocardiography (n=6). Results: The expression of Wwp1 during postnatal development was very dynamic, peaking at a concentration of 324 copies/uL in the hearts derived from 4 week old animals. This also corresponded to the timepoint when the gap junction length at the intercalated disc plateaued. Further, a 1.5-fold increase in the expression of Wwp1 in animals subjected to pressure overload was detected as compared to animals subjected to surgery without pressure overload (p&lt;0.007). Interestingly, the concentration of Wwp1 message in pressure overloaded animals (331 copies/uL) was nearly identical to that found in 4 week old wild type animals during normal postnatal development. Consistent with the level of Wwp1 correlating with cardiomyocyte hypertrophy, animals lacking Wwp1 had a 23-42% decrease in left ventricular mass (p&lt;0.01) whereas transgenic animals overexpressing Wwp1 had a 28-50% increase in left ventricular mass (p&lt;0.005) as compared to wild type controls between 4 and 8 weeks of age. Conclusions: This study shows that expression of Wwp1 is upregulated during hypertrophy and this correlates with ultrastructural changes at the intercalated disc.
The British Society for Rheumatology Biologics Register
Authors: K Watson
Journal: Annals of the Rheumatic Diseases (2005)

The British Society for Rheumatology (BSR) established a nationwide register for patients with rheumatological disorders treated with biologic agents. The register is designed as a national prospective study whose primary purpose is to assess long term toxicity from the use of these agents in routine practice. In addition, the data will be capable of addressing the benefits from their use in relation to their toxicity. One specific feature of the BSR register is the recruitment and collection of data from a parallel comparison group, comprising patients with active rheumatoid arthritis treated with conventional disease modifying agents. Both class specific and drug specific analyses of the group treated with biologicals are planned.
Oncogenic ERBB3 Mutations in Human Cancers
Authors: Bijay S. Jaiswal, Noelyn M. Kljavin, Eric W. Stawiski, Emily Chan, Chaitali Parikh, Steffen Durinck, Subhra Chaudhuri, Kanan Pujara, Joseph Guillory, Kyle A. Edgar, Vasantharajan Janakiraman, Rolf-Peter Scholz, Krista K. Bowman, Maria Lorenzo, Hong Li, Jiansheng Wu, Wenlin Yuan, Brock A. Peters, Zhengyan Kan, Jeremy Stinson, Michelle Mak, Zora Modrusan, Charles Eigenbrot, Ron Firestein, Howard M. Stern, Krishnaraj Rajalingam, Gabriele Schaefer, Mark A. Merchant, Mark X. Sliwkowski, Frederic J. de Sauvage, Somasekar Seshagiri
Journal: Cancer Cell (2014)
ITALY
Journal: JAMA (1926)

<h3>The Annual Session of the Italian Society of Internal Medicine</h3> The Società italiana di medicina interna held its annual session, October 28-30, some of the meetings of which were attended also by members of the Società italiana di chirurgia. Senator Maragliano, the president of the society, was in the chair, assisted by the two vice presidents, Senator Queirolo, clinical physician of Pisa, and Professor Giuffré, clinical physician of Palermo; Senator Fedele, minister of public instruction, and General Capo Della Valle, M.D. <h3>THE OPENING CEREMONIES</h3> In the opening address, Professor Maragliano emphasized that Italy has not sufficiently realized the part that medicine may play in the intellectual and political development of a country. Italy has heretofore relied almost entirely on belleslettres and art as the bases for the estimate placed on it abroad, not valuing sufficiently the authority that may come to a country through the exportation, as it were, of
Abstract 5206: Role of super-enhancers in HPV+ head and neck squamous cell carcinoma
Authors: Fernando T. Zamuner, Ilya Vorontsov, Emily Flam, Vera Mukhina, Ludmila Danilova, Tingting Ou, Elena Stavrovskaya, Theresa Guo, Eric Windsor, Dylan Z. Kelley, Michael Parfenov, Michael Considine, Elana J. Fertig, Alexander Favorov, Daria A. Gaykalova
Journal: Cancer Research (2019)

Abstract Head and neck squamous cell carcinomas (HNSCC) are the sixth leading cause of cancer worldwide with different incidences, mortalities, and prognosis for different subsites. Infection by Human Papilloma Viral (HPV) can cause the development of HPV+ HNSCC, the most rapidly growing population of cancer patients. The molecular biology of HPV+ HNSCC is related to abnormal transcriptional regulation. Super-enhancers (SEs) were recently identified as critical regulators of gene expression during cell differentiation and disease development. SEs are long clusters of enhancers that recruit master transcription factors (TFs) and coactivators to regulate the expression of target genes. We have recently developed a new whole-genome analytical pipeline to optimize ChIP-Seq procedures on primary surgical samples, and this protocol helped us to define the whole-genome distribution of H3K27ac, the hallmark of SEs, in HPV+ HNSCC samples. To detect SEs, we used a novel LILY algorithm that corrects the ChIP-Seq signal for copy number variation and CpG density. The analysis revealed that HPV+ HNSCC-specific SEs regulate genes critical for head and neck cancer development, such as EGFR, TP63, JAG1, IRF6, SMAD3, MAP4K2, SNAI1, TNFAIP3, ANO2, and TNFRSF1A. These genes are located in the vicinity of HNSCC-specific SEs, and the expression of those genes was altered by JQ1, the inhibitor of BRD4, the main component of SE machinery, supporting the role of SE in their regulation. The following Cistrome analysis allowed us to elucidate the TF composition of the SE machinery. Thus, we have found out that P63, P53, SOX2, FOSL1, SMAD3, and SNAI2 are TFs that are the most overrepresented in the HPV+ HNSCC-specific SEs. These comprehensive analyses have revealed novel insight into the HPV+ HNSCC biology and paved the basis for the implications for epigenetic therapeutics for this tumor types, and potentially other virus-related malignancies. Citation Format: Fernando T. Zamuner, Ilya Vorontsov, Emily Flam, Vera Mukhina, Ludmila Danilova, Tingting Ou, Elena Stavrovskaya, Theresa Guo, Eric Windsor, Dylan Z. Kelley, Michael Parfenov, Michael Considine, Elana J. Fertig, Alexander Favorov, Daria A. Gaykalova. Role of super-enhancers in HPV+ head and neck squamous cell carcinoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 5206.
Keratinocyte Growth Factor (KGF) Is Required for Post-Natal Thymic Regeneration.
Authors: Onder Alpdogan, Vanessa M. Hubbard, Stephanie J. Muriglan, Adam A. Kochman, Jeffrey M. Eng, Johannes L. Zakrzewski, Gabrielle L. Goldberg, Odette M. Smith, Elisha Waldman, Marcel R.M. van den Brink
Journal: Blood (2004)
ASSLD/AHPBA Surgery Forum
Journal: Hepatology (1995)

Circadian variation in the onset of acute aortic dissection (AAD) has been less investigated than other cardiovascular diseases. We performed a meta-analysis to assess the presence of an circadian rhythmic variability of AAD onset. Eligible studies were observational studies enrolling patients with AAD and reporting a circadian variation in AAD. Study-specific estimates, that is, 2-hour incidence of AAD, were combined using the random-effects model. Chronobiological analysis (analysis of circadian rhythmicity) was performed by applying a partial Fourier series to the pooled 2-hour incidence using the weighted least-squares method. We identified 7 eligible studies enrolling a total of 1,827 patients with AAD. Pooled 2-hour period incidence of AAD was 3.4% in 0:00 to 2:00, 4.8% in 2:00 to 4:00, 5.4% in 4:00 to 6:00, 9.6% in 6:00 to 8:00, 13.8% in 8:00 to 10:00, 11.1% in 10:00 to 12:00, 8.1% in 12:00 to 14:00, 8.9% in 14:00 to 16:00, 8.8% in 16:00 to 18:00, 7.0% in 18:00 to 20:00, 8.1% in 20:00 to 22:00), and 5.5% in 22:00 to 24:00. Chronobiological analysis (nonlinear Fourier rhythm analysis) identified a significant (p = 0.0082) circadian pattern in the occurrence of AAD with a peak in 8:00 to 10:00 and a nadir in 0:00 to 2:00. Pooled analysis demonstrated significantly more incidence in 8:00 to 10:00 than in 0:00 to 2:00 (risk ratio 3.59, 95% confidence interval 2.19 to 5.90, p<0.00001). The incidence of AAD was 8.8%, 15.5%, 25.0%, 17.7%, 16.1%, and 13.8% in 0:00 to 4:00, 4:00 to 8:00, 8:00 to 12:00, 12:00 to 16:00, 16:00 to 20:00, and 20:00 to 24:00, respectively. A significant circadian pattern was found in the occurrence of AAD with a peak in 8:00 to 10:00 and a nadir in 0:00 to 2:00.
M4 and M9 antibodies in the overlap syndrome of primary biliary cirrhosis and chronic active hepatitis: Epitopes or epiphenomena?
Authors: P Davis
Journal: Hepatology (1992)

Before the identification of the major mitochondrial antigens of primary biliary cirrhosis as components of the 2-oxo-acid dehydrogenase enzyme family, mitochondrial autoantigens were believed to be extremely heterogeneous and were divided into nine subtypes termed M1 to M9. This classification was based on the data derived from the relatively nonspecific biochemical and immunological techniques that were available. After the cloning and definition of the major autoantigens, more than 95% of the sera of patients with primary biliary cirrhosis were found to react with components of the 2-oxo-dehydrogenase enzymes; these enzymes correspond to the old M2 classification. Two other “M” species, dubbed M4 and M9, have attracted significant attention because they have been postulated to be prognostic indicators and more recently have been tentatively identified respectively as sulfite oxidase (EC 1.8.3.1) and glycogen phosphorylase (EC 2.4.1.1). Indeed, patients with the “overlap syndrome” are reported to have antibodies to M4 and a poor prognosis, whereas patients with antibodies to M9 have a favorable prognosis. To address the significance and definition of M4 and M9, we performed in-depth studies of sera from 11 patients with the overlap syndrome, 75 patients with primary biliary cirrhosis, 19 chronic active hepatitis patients, 13 patients with primary sclerosing cholangitis, 10 patients with cholangiocarcinoma, 20 patients with systemic lupus erythematosus, 20 patients with alcoholic cirrhosis, 17 patients with scleroderma and 30 normal individuals, using techniques of ELISA, complement fixation, immunoblotting and enzyme inhibition. We report herein that we were unable to show any disease-specific reactivity toward the proposed M4 and M9 antigens. We offer potential explanations for false-positive readings and, most importantly, propose that the “M” nomenclature be discontinued and that autoantigens be designated by their proven and reproducible biochemical identity. (HEPATOLOGY 1992;16:1128–1136.)
A Cross-Sectional Analysis of Cardiovascular Disease in the Hemophilia Population
Authors: Suman L. Sood, Dunlei Cheng, Amy D Shapiro, Craig M. Kessler, Nigel S. Key, Doris V. Quon, M. Elaine Eyster, Marilyn J. Manco-Johnson, Christine L. Kempton, Patrick F. Fogarty, Margaret V. Ragni, Joan Cox Gill, Philip Kuriakose, Annette von Drygalski, Peter A. Kouides, Miguel Antonio Escobar, Anne T. Neff, Tzu-Fei Wang, Cindy A Leissinger, Sarah Galdzicka, Barbara A. Konkle
Journal: Blood (2014)
"The Phaedra Complex"
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Learning how phytochemicals help fight disease
Authors: C. Marwick
Journal: JAMA (1995)

WHILE MANY organizations such as the National Cancer Institute (NCI) and American Heart Association continue to recommend diets low in fat and high in fiber to reduce the chance of developing cancer and heart disease, it is becoming clear that research into the connection between foods and disease has moved onto a more sophisticated plane. Detailed studies at the biochemical and even molecular level are providing new information about the role phytochemicals, the active compounds in dietary fruits and vegetables, play in preventing, and sometimes treating, malignant disease. Most of this research has been done during the past 7 years, said Ritva R. Butrum, PhD, vice president of the American Institute for Cancer Research, who was interviewed during the group's annual meeting in Washington, DC. The meeting attracted some 400 scientists, the largest attendance in the history of the 12-year-old organization. "We are far from definitive findings, but I think
Optics
Authors: John H. Dunnington
Journal: JAMA (1961)

The author states that<i>Optics</i>serves the student ophthalmologist "as preparation for his study of refraction of the eye and as background for his understanding of physiological optics and visual physiology." The broad field of elementary geometrical optics is treated thoroughly, with particular emphasis on the ophthalmic aspects of this subject. An attempt has been made to restrict the use of mathematics, and the mathematics present does not require unusual aptitude. Orientation is provided by a brief introductory review of the physical nature of light. A clear explanation of the vergence concept results in an intuitive understanding of image-formation by thin lenses. Thin-lens theory is applied to the problems of ocular refraction, and the characteristics of the optical system of the eye are described. Equations and diagrams assist in presenting the theory of image-formation by optical systems and by spherical refracting surfaces. The aberrations of spherical surfaces and the astigmatism
UNDERSTANDING PSYCHOTHERAPY
Authors: JOHN C. WHITEHORN
Journal: American Journal of Psychiatry (1955)

Psychotherapy is a planned and organized pattern of action designed to cure or alleviate a mental illness or a morbid emotional state. Psychotherapy shades off, by almost imperceptible degrees, into a great variety of efforts to use mental influences to assist patients in rehabilitation or in some amelioration of their distress or incapacity. Attempts to explain psychotherapy have fallen in general into one of two contrasting patterns: ( 1) to learn about the noxious event or events that have happened to a person that caused a morbid emotional reaction, to discover the complex pattern that has maintained this morbid state, and to to the cause by insightful disclosure; or (2) to learn about the patient's bad patterns of reaction, and also about assets and potentialities and to evoke their constructive use in better handling of a crucially unresolved emotional problem or problems, significantly representative of the patient's morbid reaction pattern. As between these two general modes of formulating and understanding psychotherapy, that which presumes to cure the psychogenic cause of the morbid reaction has readier acceptability and higher favor in our culture. It sells better. It implies higher expectations of radical cure. It also thereby lends itself to charlatan exploitation, deliberate or unconscious. As a sustaining aspiration, it has morale-building value, but as a description it is usually inaccurate and misleading, both to patient and practitioner. The evocative formulation implies that the actual therapeutic potential is to be found and elicited in the patient, not applied by the psychotherapist. This is harder to believe, but more aptly descriptive, and teachable. Its chief shortcomings and dangers arise from lazy cynicism and superficial optimism.
MISTLETOE AS AN OXYTOCIC.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Surgery, Gynecology and Obstetrics, Chicago
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Chronic anovulation may increase postmenopausal breast cancer risk
Authors: E. R. Gonzalez
Journal: JAMA (1983)

The suspicion that chronic anovulation with unopposed estrogen production increases a woman's risk of developing breast cancer has now been confirmed—<i>in part</i>—by a large-scale, retrospective epidemiologic study. Such a patient is not at increased risk for<i>pre</i>menopausal carcinoma of the breast, but is at significantly increased risk for postmenopausal carcinoma. For that reason, proposes Carolyn B. Coulam, MD, of the Mayo Clinic, Rochester, Minn, young women with chronic anovulation syndrome should be treated early and older women with a history of premenopausal anovulation should be apprised of their statistically increased risk of developing breast cancer. Coulam, a consultant at the Mayo Clinic and director of its Reproductive Endocrinology and Infertility Clinic, reported her findings at the recent clinical congress of the American College of Surgeons (ACS) in Chicago. In the study, she and colleague John F. Annegers, PhD, currently affiliated with the University of Texas Medical School
Randomized, blinded, placebo-controlled trial of acupuncture for the management of aromatase inhibitor-associated joint symptoms in women with early-stage breast cancer
Authors: K. D. Crew, J. Capodice, H. Greenlee, L. Brafman, D. Fuentes, D. Awad, D. L. Hershman
Journal: Journal of Clinical Oncology (2009)

571 Background: Aromatase inhibitors (AIs) have become the standard of care for the treatment of postmenopausal, hormone-sensitive breast cancer (BC). However, patients receiving AIs may experience joint symptoms which can lead to early discontinuation of this effective therapy. We examined whether acupuncture improves AI-induced arthralgias in women with early stage BC. Methods: This study is a randomized, single-blinded trial of true vs sham acupuncture twice weekly for 6 weeks in postmenopuasal women with early stage BC and self-reported musculoskeletal pain related to adjuvant AI therapy. The active intervention included full body/auricular acupuncture and a joint-specific point prescription, whereas the sham arm involved superficial needle insertion at nonacupoint locations. Outcome measures included the Brief Pain Inventory-Short Form (BPI-SF), Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC), and Modified Score for the Assessment and Quantification of Chronic Rheumatoid Affections of the Hands (M-SACRAH) obtained at baseline, 3 and 6 weeks. Lower scores reflect improvement in symptoms. Results: Of 43 women enrolled, 38 were evaluable at 6 weeks. Baseline characteristics were comparable between the groups. Median age: 57 (37–77); White/Hispanic/Black/Asian: 15/21/1/1; median body mass index (kg/m 2 ): 29 (18–45). True acupuncture was associated with about a 50% decrease in mean BPI-SF scores, whereas no change from baseline was observed for the sham acupuncture group (see table). Similar findings were seen for the WOMAC and M-SACRAH pain, stiffness, and function scores (P&lt;0.05). No adverse events were reported. Conclusions: Women with AI-induced arthralgias treated with acupuncture had significant improvement of joint pain and stiffness, which was not seen with sham acupuncture. Acupuncture is an effective and well-tolerated strategy for managing this common treatment-related side effect. [Table: see text] No significant financial relationships to disclose.