tbuckley/cabot-search huggingface dataset:
Status Report on the Acquired Immunodeficiency Syndrome
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract P225: Obesity Genetic Risk Alleles Do Not Substantially Contribute to the Association Between Gestational Diabetes Exposure and Childhood Adiposity
Authors: Sridharan Raghavan, Weiming Zhang, Ivana V Yang, Tasha Fingerlin, Dana Dabelea
Journal: Circulation (2017)

Background: Prior work has demonstrated a strong association between gestational diabetes mellitus (GDM) exposure and childhood adiposity. However, it is unknown whether this association is attributable to specific intrauterine effects or merely to genetic transmission of risk alleles associated with obesity or other metabolic traits. We aimed to assess whether obesity and insulin resistance associated genetic risk alleles explain the association between gestational diabetes exposure and childhood adiposity. Study Population: Children aged 7 to 12 years enrolled in the Exploring Perinatal Outcomes in Children (EPOCH) Study who have genome-wide common variant genotyping (n=282), 82 of whom were exposed to GDM in utero and 200 of whom were not. Methods: Genetic risk scores (GRS) for body mass index (BMI) and insulin resistance (IR) were calculated by summing the count of 91 BMI-raising or 10 insulin resistance-raising risk alleles, respectively. Multivariable linear and logistic regression were used where appropriate to estimate associations between offspring GRS and maternal exposures (GDM and pre-pregnancy overweight/obesity [BMI &gt;= 25]), as well as offspring GRS and childhood obesity traits (BMI and childhood waist circumference), adjusting for clinical and demographic covariates. Contribution of offspring GRS to association between maternal GDM or pre-pregnancy overweight/obesity and childhood adiposity was estimated by comparing the regression coefficient for the exposure variable in models with and without GRS. Results: The offspring BMI GRS was weakly associated with GDM (p=0.05), and more strongly associated with maternal pre-pregnancy overweight/obesity (p=0.001). Offspring BMI GRS was also strongly associated with childhood BMI (p=0.006) and waist circumference (p=0.02), whereas the insulin resistance GRS was not associated with GDM, maternal pre-pregnancy overweight/obesity, childhood BMI, or waist circumference. Offspring BMI genetic risk explained only 7.7% (95% CI -3.3, 18.8; p=0.2) and 5.8% (95% CI -3.1, 14.8; p=0.2) of the associations between GDM and childhood BMI and waist circumference, respectively. Similarly, offspring BMI genetic alleles explained only 4.8% (95% CI -5.4, 14.9; p=0.4) and 4.0% (95% CI -5.4, 13.4; p=0.4) of the associations between maternal pre-pregnancy overweight/obesity and childhood BMI and waist circumference, respectively. Conclusions: Genetic risk for obesity does not substantially explain the association between GDM exposure and childhood adiposity. The association between GDM and childhood adiposity is likely explained through alternative pathways, either through direct intrauterine effects or through shared postnatal environment.
Urological management of the meningomyelocele patient
Authors: D. A. Culp
Journal: JAMA (1970)

In 1964, Graf et al<sup>1</sup>analyzed a series of 50 cases with spina bifida and meningomyelocele and demonstrated that the ultimate prognosis of the patients who survived their early neurological problems depended upon the condition and function of the upper urinary tract and that the morphologic state and functional capacity of the upper urinary tract could be assessed by roentgenographic means. Furthermore, they demonstrated that diversion of urine from the lower urinary tract failed to prevent progressive, silent upper urinary tract changes that eventually lead to renal failure. In spite of the diversion of urine from the lower urinary tract, ureterectasis developed in 73% of the patients in the series, ureteral reflux in 61%, and reduction in renal function in 46%. After reviewing their findings they suggested that supravesical diversion of urine by ileal conduit was an effective corrective measure in selected cases. As a result of this study,
Sweet Gum
Authors: John Savoie
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reflections on the Pathologic Physiology of Atherosclerosis
Authors: Theodore B. Van Itallie, William C. Felch
Journal: New England Journal of Medicine (1960)

Serum Lipids and AtherogenesisWith this necessarily sketchy discussion of lipid physiology as a background, it is appropriate to consider what the relation of the serum lipids and atherosclerosis might be. Since most lipids travel in the circulation in the form of lipoprotein complexes, they presumably precipitate or dissociate within the intima in the same form.§ If this assumption is correct, it becomes mandatory to attempt to determine the conditions under which such lipid precipitation might take place.These conditions have not been adequately defined. However, animal experiments have shown that when an increased serum concentration of cholesterol-rich lipoproteins is . . .
Effects of cimetidine on the elimination and actions of ethanol
Authors: J. Feely
Journal: JAMA (1982)

The influence of cimetidine hydrochloride (300 mg four times daily for seven days) on plasma ethanol concentrations and the subjective assessment of intoxication after a single oral dose of ethanol (0.8 g/kg) were investigated in a randomized double-blind placebo controlled study in six volunteers. Compared with the placebo, cimetidine produced a small increase in both the peak plasma ethanol level (from 146 ±5.2 to 163 ±7.6 mg/dL, mean±SEM SEM) and the area under the ethanol concentration time curve (from 717±17 to 771 ±44 mg/dLXhr). In addition, using a visual analogue scale, subjects rated themselves more intoxicated at their peak of intoxication while receiving cimetidine. These results suggest that cimetidine has a small effect on the handling of ethanol in humans. (<i>JAMA</i>1982;247:2819-2821)
John Keats, physician and poet
Authors: R. Gittings
Journal: JAMA (1973)

Readers do not generally realize how short the writing life of J John-Keats actually was. It is well known, of course, that he died of tuberculosis when only a few months more than twenty-five years old; but the extent of his works, as large as that of most poets with a normal age span, might suggest that he began, like his contemporaries Shelley and Byron, at some precociously early age. This is far from true. The ranks of Keats's poems are notably not swelled by juvenilia, and for a very simple reason. On well-attested authority, he did not write a line of original English verse until probably the spring of 1813, shortly after his eighteenth birthday. How comparatively late this was for the first utterance of a major English poet may be seen by reflecting that, at almost this exact moment, Alfred Tennyson, the major poet of the next generation, was
The acquired immunodeficiency syndrome. Commentary. Council on Scientific Affairs
Journal: JAMA (1984)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Massachusetts Medical Society
Authors: L. S. McK.
Journal: New England Journal of Medicine (1968)

HOWARD FRANK ROOT, M.D.Howard Frank Root was born in Ottumwa, Iowa, on August 28, 1890, and died at his home in Brookline, Massachusetts, on November 17, 1967. He was one of five children born to Mary and Frank Root. He graduated from the local high school in 1909 with a scholarship to Harvard, entered Harvard College in the fall and graduated Phi Beta Kappa in 1913.During his four years in Cambridge, he came to know the underprivileged through his work with Phillips Brooks House assisting in the activities of the Boy's Club. When unable to meet the cost . . .
Case of Snakebite Treated with Calmette's "Antivenene Serum:" Recovery
Authors: S. J. Rennie
Journal: BMJ (1899)

On referring to the table showing the diphtheria mortality -for the three colonies, and for England and Wales for the last fifteen years there will be found, I think, evidence that this statement does not hold good of the metropolis alone.When we consider that a fall of IO per ioo,ooo in the annual mor- tality of diphtheria-a much smaller fall than might be ex- pected from the experience of the Australian colonies-would, in a population of 30 millions, mean the annual saving of 3,ooo children from a cruel and painful death, I think we are justified in pressing the results obtained in these Colonies on the attention of our professional brethren in the mother country.
Multicentre aneurysm screening study (MASS): cost effectiveness analysis of screening for abdominal aortic aneurysms based on four year results from randomised controlled trial
Authors: None Multicentre Aneurysm Screening Study Group
Journal: BMJ (2002)

To assess the cost effectiveness of ultrasound screening for abdominal aortic aneurysms.Primary analysis: four year cost effectiveness analysis based directly on results from a randomised controlled trial in which patients were individually allocated to invitation to ultrasound screening (intervention) or to a control group not offered screening. Secondary analysis: projection of the data, based on conservative assumptions, to indicate likely cost effectiveness at 10 years.Four centres in the United Kingdom. Screening delivered in primary care settings with follow up and surgery offered in the main hospitals Participants: Population based sample of 67 800 men aged 65-74 years.Mortality from and costs (screening, follow up, elective and emergency surgery) related to abdominal aortic aneurysm; cost per life year gained.Over four years there were 47 fewer deaths related to abdominal aortic aneurysms in the screening group than in the control group, but the additional costs incurred were pound 2.2m. After adjustment for censoring and discounted at 6% the mean additional cost of the screening programme was pound 63.39 ($97.77, euro;100.48) (95% confidence interval pound 53.31 to pound 73.48) per patient. The hazard ratio for abdominal aortic aneurysm was 0.58 (0.42 to 0.78). Over four years the mean incremental cost effectiveness ratio for screening was pound 28 400 ( pound 15 000 to pound 146 000) per life year gained, equivalent to about pound 36 000 per quality adjusted life year. After 10 years this figure is estimated to fall to around pound 8000 per life year gained.Even at four years the cost effectiveness of screening for abdominal aortic aneurysms is at the margin of acceptability according to current NHS thresholds. Over a longer period the cost effectiveness will improve substantially, the predicted ratio at 10 years falling to around a quarter of the four year figure.
Drug war intelligence gathering: risky, but useful to physicians
Authors: J. W. Zylke
Journal: JAMA (1988)

A PATIENT in the emergency department says he has been taking milk, and he doesn't mean the homogenized, pasteurized kind. How can a physician find out what he has taken? The patients in most practices are asking more questions about illicit drugs, but physicians may not be aware which of these are circulating in the community. How do they get more information? If you live in New York City, you might call William Hopkins. Hopkins is the supervisor of the Street Research Unit in the New York State Division of Substance Abuse Services. The unit, the only one of its kind, has been so successful that the National Institute on Drug Abuse has contacted Hopkins about starting similar programs in other parts of the country. At a recent American Academy of Pediatrics meeting, Hopkins spoke about his unit and the drug information it gathers on the street. He says more
Misoprostol and Gastrointestinal Complications in Patients Taking Nonsteroidal Anti-Inflammatory Drugs for Rheumatoid Arthritis
Authors: R. Madhok
Journal: Annals of Internal Medicine (1996)

Letters15 May 1996Misoprostol and Gastrointestinal Complications in Patients Taking Nonsteroidal Anti-Inflammatory Drugs for Rheumatoid ArthritisR. Madhok, A. McEntegart, and N. MaidenR. MadhokGlasgow Royal Infirmary; Glasgow, the United KingdomSearch for more papers by this author, A. McEntegartGlasgow Royal Infirmary; Glasgow, the United KingdomSearch for more papers by this author, and N. MaidenGlasgow Royal Infirmary; Glasgow, the United KingdomSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-124-10-199605150-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I read with interest the report by Silverstein and colleagues [1]. As presented, the data are perhaps more optimistic than is justified. An alternative and perhaps more useful presentation of results for the clinician is the number of patients requiring treatment to prevent one complication [2].I calculated that to prevent any complication, 286 patients would require treatment. Misoprostol treatment would be required in 586 patients to prevent one perforation and in 500 patients to avoid one serious complication excluding perforation.Because the manner in which study results are presented can influence physician judgment about the treatment ...References1. Silverstein FE, Graham DY, Senior JR, Wyn Davies H, Struthers BJ, Bittman RM, et al. Misoprostol reduces serious gastrointestinal complications in patients with rheumatoid arthritis receiving nonsteroidal anti-inflammatory drugs. A randomized, double-blind, placebo-controlled trial. Ann Intern Med. 1995; 123:241-9. Google Scholar2. Cook RJ, Sackett DL. The number needed to treat: a clinically useful measure of treatment effects. BMJ. 1995; 310:452-4. Google Scholar3. Forrow L, Taylor WC, Arnold MR. Absolutely relative: how research results are summarised can affect treatment decisions. Am J Med. 1992; 19:121-4. Google Scholar Author, Article, and Disclosure InformationAffiliations: Glasgow Royal Infirmary; Glasgow, the United Kingdom PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 May 1996Volume 124, Issue 10Page: 926KeywordsDrugsPatientsRheumatoid arthritisStatistical data Issue Published: 15 May 1996 CopyrightCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Association between curative treatment after transarterial radioembolization and better survival outcomes in patients with hepatocellular carcinoma
Authors: Yoon Ah Kim, Han Ah Lee, Jae Seung Lee, Hye Won Lee, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Soon Ho Um, Kwang-Hyub Han, Yeon Seok Seo, Seung Up Kim
Journal: Journal of Hepatology (2020)
Structural Mechanism for Modulation of Synaptic Neuroligin-Neurexin Signaling by MDGA Proteins
Authors: Jonathan Elegheert, Vedrana Cvetkovska, Amber J. Clayton, Christina Heroven, Kristel M. Vennekens, Samuel N. Smukowski, Michael C. Regan, Wanyi Jia, Alexandra C. Smith, Hiro Furukawa, Jeffrey N. Savas, Joris de Wit, Jo Begbie, Ann Marie Craig, A. Radu Aricescu
Journal: Neuron (2021)

(Neuron 95, 896–913; August 16, 2017) It has come to our attention that there is an error in our report regarding the ASD-linked NL3 mutation Arg451Cys and its potential impact on the NL–MDGA interaction. It concerns the paragraph “The ASD-Linked NL3 Mutation Arg451Cys Prevents Suppression of Synapse Formation by MDGA1” and the associated Figures 7, S8B, S8C, and S8D. The ASD-linked Arg→Cys (R→C) mutation in human NL3 corresponds to Arg451 (sequence motif RKTLVA) in NL3 lacking spliced sequence A (SSA; UniProt entry Q9NZ94-2). However, we erroneously introduced the mutation based on the sequence numbering of NL3 containing the 20-residue spliced sequence A1 (UniProt entry Q9NZ94-1), which, by chance, also has an Arg at position 451 (sequence motif RETIKF). This latter mutation locates to the Site II interface and resembles the other ΔSite II mutants we described in Figure 6A. The correct R451C mutation, however, is not situated in either the Site I or Site II NL–MDGA interfaces. Therefore, our conclusion that R451C prevents NL–MDGA complex formation is wrong, and any speculation based on it in the Discussion section may be disregarded. We note that this error has no impact on the validity of any of the crystal structures or other results. Furthermore, we noticed two unrelated minor errors within Figures 2, 4, and S3. In Figures 2A and S3A, a N-linked glycosylation site is incorrectly shown in the intracellular (IC) tail of NL1.Figure S3ASequence Alignment of the NL1, -2, -3, -4 and -5 Cholinesterase Domains, Related to Figure 2View Large Image Figure ViewerDownload Hi-res image Download (PPT) In Figure 4C, there is a sign error in the bottom left panel: it reads −TΔS = −1.02 kcal mol−1 instead of 1.02 kcal mol−1. Therefore, ΔG = −8.66 kcal mol−1 instead of −6.62 kcal mol−1. The value for the KD is correct, however. The authors apologize for any confusion the errors may have caused. Structural Mechanism for Modulation of Synaptic Neuroligin-Neurexin Signaling by MDGA ProteinsElegheert et al.NeuronAugust 16, 2017In BriefElegheert et al. present the crystal structure of the autism-linked post-synaptic protein MDGA in complex with the synapse organizer neuroligin, providing a structural and mechanistic basis for potentially brain-wide modulation of synaptic neuroligin-neurexin signaling by MDGA proteins. Full-Text PDF Open Access
Misspelled Name
Journal: JAMA (1976)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Gastritis and gastric cancer.
Journal: BMJ (1972)

in younger patients, though it must be recognized that fre- quently this may require a bilateral block dissection, since many of these tumours metastasize to both sides of the neck.One of the common causes of death is recurrence in the cer- vical region, and E. W. Strong and colleagues" have shown that the rate can be reduced by giving low doses of irradiation before operation.In a controlled trial they found re- duction of cervical recurrence rates from 50% to 31 % when this was done. 1