tbuckley/cabot-search huggingface dataset:
Altered lipid raft–associated signaling and ganglioside expression in T lymphocytes from patients with systemic lupus erythematosus
Authors: Elizabeth C. Jury, Panagiotis S. Kabouridis, Fabian Flores-Borja, Rizgar A. Mageed, David A. Isenberg
Journal: Journal of Clinical Investigation (2004)

Systemic lupus erythematosus (SLE) is characterized by abnormalities in T lymphocyte receptor–mediated signal transduction pathways. Our previous studies have established that lymphocyte-specific protein tyrosine kinase (LCK) is reduced in T lymphocytes from patients with SLE and that this reduction is associated with disease activity and parallels an increase in LCK ubiquitination independent of T cell activation. This study investigated the expression of molecules that regulate LCK homeostasis, such as CD45, C-terminal Src kinase (CSK), and c-Cbl, in lipid raft domains from SLE T cells and investigated the localization of these proteins during T cell receptor (TCR) triggering. Our results indicate that the expression of raft-associated ganglioside, GM1, is increased in T cells from SLE patients and LCK may be differentially regulated due to an alteration in the association of CD45 with lipid raft domains. CD45 tyrosine phosphatase, which regulates LCK activity, was differentially expressed and its localization into lipid rafts was increased in T cells from patients with SLE. Furthermore, T cells allowed to "rest" in vitro showed a reversal of the changes in LCK, CD45, and GM1 expression. The results also revealed that alterations in the level of GM1 expression and lipid raft occupancy cannot be induced by serum factors from patients with SLE but indicated that cell-cell contact, activating aberrant proximal signaling pathways, may be important in influencing abnormalities in T cell signaling and, therefore, function in patients with SLE.
Letter: Superior vena cava syndrome
Authors: Ken C. Davidson
Journal: JAMA (1975)

<h3>To the Editor.—</h3> I would respectfully like to take exception of a SPECIAL COMMUNICATION (231:58,1975) in which Drs. Lokich and Goodman, in discussion of the venous access procedures, raise the specter of an undue complication rate associated with attempts at venography in the evaluation of superior vena cava syndrome (SVCS). In light of my previous experience and discussion with others, I raise exception with the idea that venography is fraught with great difficulty and complication when performed judiciously and with care. Venographic techniques in this day and age involve the use of flexible, relatively atraumatic catheters, guide wires, and puncture techniques that need not result in increased thrombosis, phlebitis, bleeding, hematoma formation, or other of the complications that they mention. Simple percutaneous needle puncture of a peripheral vein, usually in the forearm or antecubital area, followed by the introduction of a smallgauge plastic catheter over a flexible guide wire under
The Royal Medical Society, Edinburgh
Journal: BMJ (1900)

In another part of the present number, we have referred to this excellent and highly respectable Institution, the members of which resolved, on its completing its centenary, to celebrate the event by an appropriate festival.Accor- dingly, on Friday, the 17th February, this celebration took place, at the Hopetoun rooms.Owing to the season of the year, and the very general pre- valence of the influenza, members from a distance were, for the most part, pre- vented from attending; nevertheless, one hundred and sixteen individuals assembled on the occasion.The proceedings commenced with the delivery, by Mr. Carpenter, senior president, of an oration, which was characterized no less by eloquence and power than by elegance of style.The chief object of the orator was to detail the leading features of the history of the Institution, and to point out the numerous advantages which had accrued to medical science from its establishment.We regret that our limits prevent us from giving any lengthened extracts from this discourse.We must, however, quote part of a passage relating to the connexion of some of our most distinguished men, in the early part of their career, with this Society; a circumstance extremely inte- resting in the literary history of our profession.We are much mistaken if
Xenotransplantation Advisory
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Incorrect Word
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
It's Time
Authors: Kathleen Franco-Bronson
Journal: Annals of Internal Medicine (1999)

Ad Libitum20 July 1999It's TimeKathleen Franco-Bronson, MDKathleen Franco-Bronson, MDThe Cleveland Clinic Foundation; Cleveland, OH 44195-5001 (Franco-Bronson)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-131-2-199907200-00010 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail She was sitting in the big chair with her back to the door when we entered. The tiny, white-haired woman could barely be spotted over the top. It was as if she had been placed there, frozen in time, and unable to move. Her face told us that she was not happy to greet more white coats into her space. But there we were, and she answered our questions politely, courteously. “Yes, I had a wonderful husband, a lovely, successful daughter, and three close friends. A good life, perhaps a little boring by some standards … .”Why did I ... Author, Article, and Disclosure InformationAffiliations: The Cleveland Clinic Foundation; Cleveland, OH 44195-5001 (Franco-Bronson)Corresponding Author: Kathleen Franco-Bronson, MD, The Cleveland Clinic Foundation, 9500 Euclid Avenue, P-57, Cleveland, OH 44195-5001. Previousarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAntiestrogens and Selective Estrogen Receptor Modulators as Multifunctional Medicines. 2. Clinical Considerations and New Agents 20 July 1999Volume 131, Issue 2Page: 135KeywordsDeceptionTongue ePublished: 15 August 2000 Issue Published: 20 July 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Delayed-type hypersensitivity to low molecular weight heparins and heparinoids: cross-reactivity does not depend on molecular weight
Authors: R.H. Grims, W. Weger, H. Reiter, E. Arbab, B. Kränke, W. Aberer
Journal: British Journal of Dermatology (2007)

Cross-reactivity is a widespread phenomenon in patients who develop cutaneous delayed-type hypersensitivity (DTH) reactions to low molecular weight heparins (LMWHs). As molecular weight is believed to be a key determinant of sensitization to heparins, the recently developed LMWH bemiparin, with the lowest molecular weight of all LMWHs, appeared to be a significant improvement.To evaluate cross-reactivity between bemiparin and several other LMWHs and heparinoids by means of subcutaneous testing. Methods Test doses of bemiparin and several other LMWHs/heparinoids were given to eight patients with a history of local eczematous reactions after subcutaneous injection of enoxaparin.Seven of eight patients showed cross-reactivity following subcutaneous injection of bemiparin. In addition, nearly all tested substances caused local eczematous reactions in at least some patients, with the exception of fondaparinux, which was well tolerated by all patients. Of all substances tested, bemiparin had the highest cross-reactivity with enoxaparin. Substances with a lower molecular weight did not cross-react less frequently than the others.No significant correlation was found between the molecular weight of the tested substances and the frequency of DTH reactions. In patients with DTH to enoxaparin, the LMWH bemiparin is not a suitable alternative.
Radiation Research, New York
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CORRESPONDENCE
Authors: S. E. Dore
Journal: British Journal of Dermatology (1942)

Journal Article CORRESPONDENCE Get access S. E. Dore S. E. Dore London Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 54, Issue 3, 1 March 1942, Page 91, https://doi.org/10.1111/j.1365-2133.1942.tb10618.x Published: 01 March 1942
Studies in Ethics for Nurses.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Treatment of the Opium Neurosis
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Treatment of Hypertension in Patients With Coronary Artery Disease
Authors: Clive Rosendorff, Daniel T. Lackland, Matthew Allison, Wilbert S. Aronow, Henry R. Black, Roger S. Blumenthal, Christopher P. Cannon, James A. de Lemos, William J. Elliott, Laura Findeiss, Bernard J. Gersh, Joel M. Gore, Daniel Levy, Janet B. Long, Christopher M. O’Connor, Patrick T. O’Gara, Olugbenga Ogedegbe, Suzanne Oparil, William B. White
Journal: Journal of the American College of Cardiology (2015)
PURULENT BRAIN DEPOSITS, AND PHLEBITIS AND THROMBOSIS OF THE CEREBRAL VEINS AND SINUSES FOLLOWING EAR DISEASE.
Authors: FRANK ALLPORT
Journal: JAMA (1892)

(<i>Continued from page 558</i>.) Case 84..—New York Medical Journal, June 12, 1886. Treated by A. Mathewson. Male, age forty. Right ear. Chronic otorrhœa; pain over mastoid; Wilde's incision; brain complication. Death. Autopsy—Caries of tympanic roof. Abscess of brain over tympanum. Case 85.—New York Medical Journal, June 12, 1886. Treated by A. Mathewson. Female, age eleven. Left ear. Chronic otorrhœa; middle ear, polypus; spontaneous opening in external mastoid plate; facial paralysis; improvement; later became worse; pain; vomiting; drowsiness; constipation; optic neuritis; convulsions. Death. Autopsy.—Dura-mater adherent to petrous bone. Pus in cerebellum. Case 86.—New York Medical Journal, June 12, 1886. Treated by A. Mathewson. Male, age five and one-half. Right ear. Acute otitis media; drum-head not perforated. Death. Autopsy.—Caries of roof of tympanum. Basilar meningitis. Case 87.—British Medical Journal, 1887, No. 1363, page 317. Treated by W. S. Greenfield. Male, age twenty-six. Left ear, Deafness; headache; vomiting; ptosis of lid;
Pathological fracture of the femoral neck
Authors: O. E. Aufranc
Journal: JAMA (1968)

Dr. Joseph S. Barr, Jr.: A 53-year-old white woman was admitted to the Massachusetts General Hospital complaining of severe pain in the right hip. The patient had twisted the right leg in moving to answer the telephone a few hours before admission. Medical history included a right radical mastectomy four years before admission for grade 2 adenocarcinoma of the breast. More than 80 regional nodes were involved with tumor. She was treated with 4,000 roentgens of high-voltage radiation to the right axilla. One year before admission the patient had undergone a left radical mastectomy for a scirrhous-type adenocarcinoma. There was evidence of malignancy in 13 regional nodes. Alkaline phosphatase value was 5.3 Bodansky units. Six months later ureteral colic developed, and retroperitoneal metastases in the right flank were found at the time of open biopsy. The alkaline phosphatase value was 8.4 Bodansky units. The patient was treated with 2,400 R
ANTE-MORTEM SECTION.
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Viewing the Journal of the National Cancer Institute
Authors: John C. Bailar III M.D., Vivian J. Heston
Journal: CA A Cancer Journal for Clinicians (1975)

In a case-control dietary study, Modan et al. (Chaim Sheba Medical Center, Tel Hashomer, Israel) supported the hypothesis that low residue food is an etiologic factor in cancer of the colon.Control subjects consumed signifi cantly more food with high fiber content than did 198 patients with colon cancer.Of the 73 items on the fiber list, 61 were eaten less frequently by the cancer patients than by the neighborhood controls, and 57 were ingested less often than by surgical controls.The authors postulate that a mechanism related to the possible carcinogenic properties of degraded biliary compounds may be impli cated.To determine the carcinogenic or cocarcinogenic effect of chronic inhalation exposure of hamsters to synthetic smog and ferric oxide particles, Nettesheim and coworkers (Oak Ridge National Laboratory, Oak Ridge, Tennessee) injected diethylnitrosamine (DEN) into the animals and then exposed them to air contaminants.The inhaled iron oxide particles enhanced DEN carcinogenesis in the lungs, but synthetic smog had neither a carcinogenic nor cocar cinogenic effect.The number of animals with lung tumors was almost double and the number of lung tumors almost triple in DEN-treated hamsters exposed to iron oxide dust compared with DEN-treated hamsters breathing filtered air.Menczer et al. (Chaim Sheba Medical Center, Tel Ha shomer, Israel) reported an association between herpesvirus type-2 antibody titers and squamous cell carcinoma of the uterine cervix in Jewish women.The percentage of type-2 positive titers among these patients was 15.4, a figure considerably lower than in other reports from different demographic areas where 50 to 60 percent of the patients were type-2 positive.The low incidence of cervical cancer among Jewish women may be related to their low reservoirs of this virus.
Benzodiazepines: dependence and withdrawal
Authors: F. J. Ayd
Journal: JAMA (1979)

In the past two decades, billions of benzodiazepine prescriptions have been written for millions of patients who have taken these substances intermittently or continuously. Extensive use has caused health authorities and government agencies to become concerned about unknown hazards of protracted benzodiazepine use, possible dependence and tolerance, and the potential incidence of withdrawal reactions. The news media have bruited charges of overuse, misuse, and abuse, of birth defects, and of death attributable to these drugs. For the most part, however, the case against benzodiazepines remains weak, and their efficacy and safety have been demonstrated. Critics attribute the widespread use of benzodiazepines to overprescribing by irresponsible physicians—a charge refuted by a recent National Institute of Mental Health survey of psychotropic drug use by 2,500 randomly selected American adults.<sup>1</sup>This survey disclosed that only 30% of highly distressed persons had taken any psychotropic drugs during the year. Even if physicians are
A Text-Book of Neuro-Anatomy
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Learning Curve
Authors: Philip R. Caropreso
Journal: JAMA (1994)

<h3>To the Editor.</h3> —I read with interest the article entitled "The Learning Curve" by Dr Gaster.<sup>1</sup>There are surgeons overwhelmed by new technologies. Nevertheless, "The Learning Curve" talks less about the process of gaining experience and more about advancing age and the inability of senior physicians to progress into the future. This is not the case and unfair. The content suggests more fiction than actual reporting of a knowledgeable observer and raises the question about the author's true intentions. The senior surgeon had completed a certifying course. The operation was not even his first laparoscopic cholecystectomy. As he struggled, he would have asked for some advice. He would not have used a scalpel to cut the cystic artery, knowing all too well that inadvertent stabbing could occur. An experienced surgeon would have selected scissors to perform the task, knowing that it is a safer instrument. If he was so