tbuckley/cabot-search huggingface dataset:
口腔扁平苔藓的局部治疗
Authors: S.‐L. Sun, J.‐J. Liu, B. Zhong, J.‐K. Wang, X. Jin, H. Xu, F.‐Y. Yin, T.‐N. Liu, Q.‐M. Chen, X. Zeng
Journal: British Journal of Dermatology (2019)

口腔扁平苔藓 (OLP) 是一种影响口腔的皮肤病,可导致进食或喝水时口腔内烧灼或刺痛不适感。可能发生溃疡,这类溃疡尤为疼痛。口腔扁平苔藓的原因在大多数情况下不明, 但可能与身体免疫系统有关。 在此研究中,来自中国的作者们旨在比较称为局部外用钙调神经磷酸酶抑制剂 (TCI) 的药物和称为局部外用皮质类固醇 (TCS) 的皮肤外用药对于 OLP 治疗的疗效和安全性。 作者们调查了来自 8 个医学数据库中报告 TCI(他克莫司、吡美莫司和环孢素)与 TCS 相比用于治疗 OLP 的全球已发表随机对照试验 (RCT)。 纳入了 21 项在 1995 至 2017 年之间发表的 RCT,涉及共计 965 名患者(他克莫司-TCS:12 项研究,578 名患者;吡美莫司-TCS:3 项研究,98 名患者;环孢素-TCS:6 项研究,289 名患者)。 作者们发现,包括他克莫司、吡美莫司和环孢素在内的 TCI 在 OLP 的短期治疗(3-8 周)疗效方面与 TCS 相似。此外,0.1% 他克莫司在复发率方面与 TCS 相似。 尽管已有少数通过误吞药物导致高水平药物的患者病例,他克莫司和环孢素的血药水平通常非常低。尽管在他克莫司和环孢素组观察到了一些不良事件(有害的副作用),但没有发现严重事件。 因此,当 OLP 不能通过 TCS 得以改善时,TCI 可能是一个备选方法。由于吡美莫司和环孢素的试验有限,以及环孢素的一些不良事件和高成本,对于未能通过 TCS 改善的 OLP,0.1% 他克莫司应作为 TCI 短期治疗的首选药物。需要更多充分设计的 RCT 来评估 TCI 相比 TCS 的长期疗效和安全性。
28032 Rapid itch improvement with upadacitinib with or without concomitant topical corticosteroids (TCS) in moderate-to-severe atopic dermatitis (AD): Results from 3 phase 3 studies (Measure Up 1, Measure Up 2, and AD Up)
Authors: Andrew Blauvelt, Michael R. Ardern-Jones, Thomas Bieber, Chih-ho Hong, Chia-Yu Chu, Meng Liu, Yang Yang, Barry Ladizinski, Henrique D. Teixeira, Brian M. Calimlim, Jacob P. Thyssen
Journal: Journal of the American Academy of Dermatology (2021)
Intracavitary cardiac pacing
Authors: N. K. Jensen
Journal: JAMA (1966)

Complications developed in four patients with heart block managed by permanent transvenous cardiac pacemaking; the complications were penetration and perforation of the right ventricle, fracture of the catheter electrode, and pacemaker-induced ventricular tachycardia-fibrillation. Analysis of these problems led to recommendations for improvement in this method of pacing.
Practical Methods in the Diagnosis and Treatment of Venereal Diseases for Medical Practitioners and Students.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mechanism of action studies of inarigivir, a novel immunomodulator against chronic hepatitis B
Authors: Kim Lam Chiok, Niraj Shil, Sreerupa Challa, Leena Suppiah, Geeta Meher, Seetharamaiyer Padmanabhan, Lakshmi Bhagat, Diane Schmidt, Kyle Korolowicz, Manasa Suresh, Santanu Bose, Brent Korba, Stephan Menne, Nezam Afdhal, Radhakrishnan Iyer
Journal: Journal of Hepatology (2020)
Nervous Diseases, Organic and Functional.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
New Treatment for Myoclonus Patients
Journal: JAMA (1980)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Commentaire de travail de Manes G et al., pp. 662
Journal: Endoscopy (2014)

See also: Randomized controlled trial comparing efficacy and acceptability of split- and standard-dose sodium picosulfate plus magnesium citrate for bowel cleansing prior to colonoscopyEndoscopy 2014; 46(08): 662-669DOI: 10.1055/s-0034-1365800
Absence of Reported Measles— United States, November 1993
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
EARLY PREPARATION FOR THE SECTION WORK.
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fusion Gene Map of Acute Lymphoblastic Leukemia Revealed By Transcriptome Sequencing of a Consecutive Cohort of 350 Cases in a Single Center
Authors: Xue Chen, Fang Wang, Panxiang Cao, Xiaoli Ma, Lili Yuan, Yang Zhang, Daijing Nie, Jiaqi Chen, Xiaosu Zhou, Ming Liu, Zhixiu Liu, Mingyue Liu, Hongxing Liu
Journal: Blood (2020)
WEDNESDAY 9TH SEPTEMBER
Authors: Weldon Poulton, D Maxwell, K Gardiner, -C Schuerer-Maly, F.-E Maly, Antibodies Kagnoff, M Parsons, A Wakefield, Sim Cosby, Smith Hudson, E Pounder
Journal: Gut (1992)

In vitro activated lymphocytes and macrophages express interleukin 2 receptor (IL-2r) on their cell membranes.IL2r has been detected on bowel mucosal lymphocytes and macrophages in inflammatory bowel disease and the soluble receptor (sIL-2r) is raised in serum and correlates with disease activity.This receptor may therefore be important in immunopathogenesis.Since there is evidence that circulating monocytes are activated in Crohn's disease, we sought the presence of IL-2r on circulating monocytes in Crohn's disease.Using two colour Fluorescein activated cell sorter analysis of lysed whole blood, IL-2r expression was measured on both lymphocytes and monocytes in 15 patients with Crohn's disease and in 6 normal controls.Purity of monocytes examined was over 90% using the monocyte marker CD14.Disease activity was measured using the Harvey Bradshaw index (HBI).Monocytes showed no expression of IL-2r suggesting that this occurs only on arrival at the inflamed bowel mucosa.However, expression of lymphocyte IL-2r was significantly raised in both active and inactive Crohn's disease (p<0.01)compared to normal controls and correlated with disease activity measured by HBI (r=0.7,p<O.01).This study provides further evidence for systemic immune activation in Crohn's disease.
Oncology Research Program
Journal: Journal of the National Comprehensive Cancer Network (2017)

The goal of the Highlights of the NCCN Oncology Research Program (ORP) is to provide readers with more information on the ORP, including studies currently accruing patients.For more information on specific trials, including patient selection criteria, please use the contact information listed with each study.For more information on the NCCN ORP, including a complete detailing of the clinical studies currently underway at NCCN Member Institutions, please access the NCCN ORP pages at NCCN.org/clinical_trials/ clinicians.asp.
Consciousness, explanatory inversion, and cognitive science
Authors: John R. Searle
Journal: Behavioral and Brain Sciences (1990)

Abstract Cognitive science typically postulates unconscious mental phenomena, computational or otherwise, to explain cognitive capacities. The mental phenomena in question are supposed to be inaccessible in principle to consciousness. I try to show that this is a mistake, because all unconscious intentionality must be accessible in principle to consciousness; we have no notion of intrinsic intentionality except in terms of its accessibility to consciousness. I call this claim the “Connection Principle.” The argument for it proceeds in six steps. The essential point is that intrinsic intentionality has aspectual shape: Our mental representations represent the world under specific aspects, and these aspectual features are essential to a mental state's being the state that it is. Once we recognize the Connection Principle, we see that it is necessary to perform an inversion on the explanatory models of cognitive science, an inversion analogous to the one evolutionary biology imposes on preDarwinian animistic modes of explanation. In place of the original intentionalistic explanations we have a combination of hardware and functional explanations. This radically alters the structure of explanation, because instead of a mental representation (such as a rule) causing the pattern of behavior it represents (such as rule-governed behavior), there is a neurophysiological cause of a pattern (such as a pattern of behavior), and the pattern plays a functional role in the life of the organism. What we mistakenly thought were descriptions of underlying mental principles in, for example, theories of vision and language were in fact descriptions of functional aspects of systems, which will have to be explained by underlying neurophysiological mechanisms. In such cases, what looks like mentalistic psychology is sometimes better construed as speculative neurophysiology. The moral is that the big mistake in cognitive science is not the overestimation of the computer metaphor (though that is indeed a mistake) but the neglect of consciousness.
Self-monitoring of blood glucose levels and intensified insulin therapy. Acceptability and efficacy in childhood diabetes
Authors: M. E. Geffner
Journal: JAMA (1983)

Prospective studies have shown that children and adolescents with diabetes have a high prevalence of serious complications and a sharp reduction in life expectancy. Recently, self-monitoring of blood glucose levels has become available and, for the first time, provides a method for determining the concentration of blood glucose with considerable accuracy. We have introduced this method of control assessment to our pediatric diabetic patient population in conjunction with a program of intensified insulin administration (two or more injections per day). This is a report of the ready acceptance of these methods by children and adolescents and their parents (53/63, or 84%). The effectiveness of this program is evidenced by a progressive and significant reduction in the percentage of glycosylated hemoglobin during a period of 18 months in a majority of the subjects. These observations suggest that improved glycemic control can be achieved in young diabetics by using multiple insulin injections and self-monitoring of blood glucose levels. Whether such control can lead to a better long-term outlook for diabetics remains to be seen. (<i>JAMA</i>1983;249:2913-2916)
Early coronary angioplasty for acute myocardial infarction complicated by cardiogenic shock: Have novel therapies led to better results? Ra�l Moreno, Eulogio Garcia, Leopoldo Perez de Isla, Manuel Abeytua, Javier Soriano, Esteban L�pez de S�, Rafael Rubio, Jos� L. L�pez-Send�n. Hospital Gregorio Mara��n, Madrid, Spain
Journal: Journal of the American College of Cardiology (2001)
Age at onset for familial epithelial ovarian cancer
Authors: C. I. Amos
Journal: JAMA (1992)

<h3>Objective.</h3> —To provide age-specific risks for ovarian cancer for relatives of ovarian cancer case patients. To characterize the age at onset for ovarian cancer for women with a single relative vs several relatives affected with ovarian cancer. <h3>Design.</h3> —Three previous studies were reexamined. The cumulative probability of ovarian cancer in first-degree relatives of women with histologically confirmed epithelial ovarian cancer and matched control subjects who participated in the Cancer and Steroid Hormone (CASH) Study was determined. The age of onset of ovarian cancer in women with and without relatives with ovarian cancer in a Washington, DC, case-control study was contrasted with that of women with at least two first-degree relatives studied at the National Cancer Institute (NCI). <h3>Results.</h3> —The CASH Study data showed that first-degree relatives of women with ovarian cancer had an increased risk for ovarian cancer, especially at older ages, when compared with relatives of control subjects. However, the median age at onset was the same among women in the Washington, DC, study with and without an affected relative. Among the women with an extensive family history of ovarian cancer studied at the NCI, the age at onset was considerably younger (47 years) than is typical for this disease (59 years). Of these, 17% had been diagnosed as having primary ovarian cancer by age 40 years. <h3>Conclusions.</h3> —Women who have one first-degree relative affected by ovarian cancer are at greater risk for ovarian cancer but not at an age earlier than the general population. The small proportion of women who have several affected relatives are, however, at a greater risk of early onset of ovarian cancer. Prophylactic oophorectomy may be reasonable for these women. (<i>JAMA</i>. 1992;268:1896-1899)
EAACI/GA<sup>2</sup>LEN/EDF guideline: definition, classification and diagnosis of urticaria
Authors: T. Zuberbier, C. Bindslev‐Jensen, W. Canonica, C. E. H. Grattan, M. W. Greaves, B. M. Henz, A. Kapp, M. M. A. Kozel, M. Maurer, H. F. Merk, T. Schäfer, D. Simon, G. A. Vena, B. Wedi
Journal: Allergy (2005)

This guideline is the result of a consensus reached during a panel discussion at the 2nd International Consensus Meeting on Urticaria, Urticaria 2004, a joint initiative of the European Academy of Allergology and Clinical Immunology Dermatology Section and the European Union (EU)‐funded network of excellence, GA 2 LEN. It covers the definition and classification of urticaria, taking into account the recent progress in identifying causes, eliciting factors and pathomechanisms of this disease. We have outlined useful diagnostic approaches for different subtypes of urticaria. This guideline was, in addition, accepted by the European Dermatology Forum (EDF) and was formally approved by the European Union of Medical Specialists (UEMS).
Post-op
Authors: Mark LaRue
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ERRATUM
Journal: Journal of Clinical Oncology (2005)

contained an error in Table 3.The last entry in Table 3 mistakenly reads, "CRC with two or more first-or seconddegree relatives with CRC or other HNPCC-related tumor (regardless of age), including cancer (endometrial, stomach, ovarian, cervical, esophageal, leukemia, thyroid, bladder, ureter and renal pelvis, biliary tract, small bowel, breast, pancreas, liver, larynx, bronchus, lung, and brain (glioblastoma), sebaceous gland adenomas, and keratoacanthomas."The correct entry should read, "CRC diagnosed with one or more first-degree relatives with an HNPCC-related tumor (colorectal, endometrial, stomach, ovarian, pancreas, bladder, ureter and renal pelvis, biliary tract, brain (usually glioblastoma as seen in Turcot Syndrome), sebaceous bland adenomas and keratoacanthomas in Muir-Torre syndrome, and carcinoma of the small bowel), with one of the cancers being diagnosed under age 50 years, OR CRC diagnosed in two or more first or second degree relatives with HNPCCrelated tumor, regardless of age."
Do house officers learn from their mistakes?
Authors: A. W. Wu
Journal: JAMA (1991)

Mistakes are inevitable in medicine. To learn how medical mistakes relate to subsequent changes in practice, we surveyed 254 internal medicine house officers. One hundred fourteen house officers (45%) completed an anonymous questionnaire describing their most significant mistake and their response to it. Mistakes included errors in diagnosis (33%), prescribing (29%), evaluation (21%), and communication (5%) and procedural complications (11%). Patients had serious adverse outcomes in 90% of the cases, including death in 31% of cases. Only 54% of house officers discussed the mistake with their attending physicians, and only 24% told the patients or families. House officers who accepted responsibility for the mistake and discussed it were more likely to report constructive changes in practice. Residents were less likely to make constructive changes if they attributed the mistake to job overload. They were more likely to report defensive changes if they felt the institution was judgmental. Decreasing the work load and closer supervision may help prevent mistakes. To promote learning, faculty should encourage house officers to accept responsibility and to discuss their mistakes. (<i>JAMA</i>. 1991;265:2089-2094)
Risk of Diabetes in Patients With Rheumatoid Arthritis Taking Hydroxychloroquine—Reply
Authors: Mary Chester M. Wasko, Helen B. Hubert, Vijaya Bharathi Lingala, Jennifer Rae Elliott, Michael E. Luggen, James F. Fries, Michael M. Ward
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal