tbuckley/cabot-search huggingface dataset:
High fiber diet in hyperlipemia. Comparison with cholestyramine treatment in type IIA hyperlipoproteinemia
Authors: P. J. Palumbo
Journal: JAMA (1978)

Fourteen patients with type Ila hyperlipoproteinemia were treated with a high fiber intake (powdered cellulose or soy hulls or both) for six months. Eight of the patients were treated with 16 g of cholestyramine resin daily without the high fiber intake for an additional six months. The cholesterol intake was comparable in both treatment programs. The mean serum cholesterol levels decreased during both, but the decrease occurred and was more pronounced in all patients treated with cholestyramine. Responsiveness to the high fiber diet was not related to an increased responsiveness to cholestyramine treatment. In most patients the serum triglyceride levels increased, and the fasting plasma glucose level did not change substantially during either treatment program. Both regimens were free of adverse side effects. (<i>JAMA</i>240:223-227, 1978)
Fatal papillary necrosis in a kidney graft
Authors: S. Tuma
Journal: JAMA (1976)

RENAL papillary necrosis has been reported as complicating pyelonephritis and diabetes,<sup>1</sup>ureteral obstruction,<sup>2</sup>and other ischemic processes.<sup>3-5</sup>Although it has been associated with kidney transplant,<sup>6,7</sup>it has not, to the best of our knowledge, caused primary acute failure of a kidney graft. We describe such a case. <h3>Report of a Case</h3> A 14-year-old girl with terminal renal failure owing to medullary cystic disease was admitted to our hospital for long-term hemodialysis in 1967. Fasting and postprandial blood glucose levels were repeatedly within normal range. A year later, in January 1968, a cadaveric kidney transplantation was performed. The warm and cold ischemic times were 55 and 140 minutes respectively. The graft failed to function, although the donor's other kidney had been successfully transplanted to another recipient, and long-term satisfactory renal function has been achieved. Angiograms made 18 days after the transplantation showed patent arterial anastomosis of the
Abstract 4179: Identification of BRCA1 and BRCA2 mutation spectrum and their founder effect in epithelial ovarian cancer from Middle East
Authors: Abdul K. Siraj, Rong Bu, Kaleem Iqbal, Nabil Siraj, Maha Alrasheed, Laila Ghazwani, Tariq Masoodi, Sandeep Kumar Parvathareddy, Khawla S. Al-Kuraya
Journal: Cancer Research (2019)

Abstract Epithelial ovarian cancer (EOC) remains the most fatal gynecological malignancies. Germline mutations in Breast Cancer susceptibility gene 1 and 2 (BRCA1 and BRCA2) have previously been estimated to contribute to 13-18% of all EOC. The prevalence and influence of BRCA1 and BRCA2 mutations in EOC in Middle Eastern population is not fully explored. Ethnic differences of ovarian cancer genomics have prompted us to investigate the spectrum of BRCA1 and BRCA2 mutations among our Middle Eastern EOC patients. To characterize the prevalence of BRCA mutations in our patients, BRCA mutation screening was performed in over 400 unselected ovarian cancer patients using Capture and/or Sanger sequencing. Seventeen short tandem repeat (STR) markers were used for founder mutation analysis. A total of 19 different types of pathogenic mutations were identified in 50 cases (40 mutant cases in BRCA1 and 10 in BRCA2). Nine mutations were recurrent accounting for 80% (40/50) of all mutant cases (9.8% (40/407) of the entire cohort). Haplotype analysis carried out on all unrelated cases with these mutations revealed only two (c.4136_4137 delCT and c.1140 dupG) sharing the same haplotypes thus representing founder Saudi mutations. Remarkably, lifetime risk estimation for these founder mutations appears to approach 100% given their complete absence in healthy controls. BRCA1 mutant cases were significantly associated with positive family history (p &amp;lt;0.0001), grade 3 tumors (p = 0.0003) and loss of BRCA1 protein expression (p &amp;lt;0.0001). 85.0% (34/40) of all BRCA1 mutant cases were of serous histology. BRCA2mutant cases were associated with loss of BRCA2 protein expression (p=0.0102) and a trend towards younger age (p=0.0505). Identification of the mutation spectrum, prevalence and founder effect in Middle Eastern population facilitates genetic counseling, risk assessment and development of cost-effective screening strategy. Citation Format: Abdul K. Siraj, Rong Bu, Kaleem Iqbal, Nabil Siraj, Maha Alrasheed, Laila Ghazwani, Tariq Masoodi, Sandeep Kumar Parvathareddy, Khawla S. Al-Kuraya. Identification of BRCA1 and BRCA2 mutation spectrum and their founder effect in epithelial ovarian cancer from Middle East [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4179.
A Manual of Bacteriology, Clinical and Applied, with an appendix on bacterial remedies, etc.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Physiological Pacemakers
Authors: V C DiCola, J W Harthorne
Journal: Annual Review of Medicine (1984)

It has long been possible to prevent death from bradycardia by using single-chamber ventricular pacemakers. Important advances in dual-chamber pacemaker technology now make physiological control of cardiac output during pacing almost a reality. These pacemakers have properly timed atrial contraction and rate variability and have significant hemodynamic advantages over ventricular pacemakers. The pathophysiology of bradycardia and the current status of physiological pacemakers are reviewed in this article.
A Clinical Lecture on Recent Advances in Abdominal Surgery
Authors: C. G. Wheelhouse
Journal: BMJ (1885)

bA 1EIl8_H. 1ZYAB\MW'U3%RL.1149 ficial effecti.And if, ia spite of, or because of, an imperfect.applioa, tion of such measures of hygiene, these and similar blood-diseases still occur sporadically, does this mean that active measures of this kind are of no use I Does it not mead rather that hygienic and preventive activity should be redoubled ?The miscarriage of precautions, in some instances, may deter the young surgeon from attempts to improve his treatment by careful ex.periment, and may tempt him to rest contentedly upon the old ways, and to leave chance and the laws of Nature to settle his patient's matters between them.This fault is natural.It is human.It iay almost be said, in some instances, to be humane.To add more to the already long list of antiseptic applications may, to some, seem superfluous; but we have by no means reached finality.Cases differ, both minutely and widely, and what suits one case may not do equally well for another.The medical practitioner, to be suc- cessful, must have a well filled pharmacopoeia; and he is obliged, above all things, to be eclectic.It may happen, on the other hand, that some successful cases have occurred consecutively in his practice.He may form upon them crude conclusions, which come under the category of views; and. he may be in haste to publish them, in order to obtain the benefits of priority.This may so influence him that he scarcely takes time or pains to ensure his results, or to know the results of others.Each experimenter may be striving his utmost to avoid the fate which overtakes the hind- most.The dangerous epigram of the French surgeon, "L'audace toujours l'audace," prompts him, with the immense aid afforded by anaesthetics and antiseptics, to risky achievements.He does not, perhaps, keep before his mind that this audacity has its sober limits, as well as its unlimited tendency to mischief.It is not difficult to be brave at the expense of one's patients.If, in search of notoriety, Empedocles plunged into the crater of Etna, such a foolish act was at least more to his credit than if he had thrown one of his friends into the vortex of a burning question, to decide a point as to the limits of resistance of the living human body to dissolution by cremation.Sanguine expectations of good results do not justify the imposition of the great risk, incurred by their failure, to the life of the patient,
Medical and Surgical Aspects of Intratracheal Goiter
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Male Reproductive Health and Environmental Xenoestrogens
Authors: Jorma Toppari, John Chr. Larsen, Peter Christiansen, Aleksander Giwercman, Philippe Grandjean, Louis J. Guillette, Bernard Jegou, Tina K. Jensen, Pierre Jouannet, Niels Keiding, Henrik Leffers, John A. McLachlan, Otto Meyer, Jorn Muller, Ewa Rajpert-De Meyts, Thomas Scheike, Richard Sharpe, John Sumpter, Niels E. Skakkebaek
Journal: Environmental Health Perspectives (1996)

Male reproductive health has deteriorated in many countries during the last few decades.In the 1990s, declining semen quality has been reported from Belgium, Denmark, France, and Great Britain.The incidence of testicular cancer has increased during the same time.Incidences of hypospadias and cryptorchidism also appear to be increasing.Similar reproductive problems occur in many wildlife species.There are marked geographic differences in the prevalence of male reproductive disorders.While the reasons for these differences are currently unknown, both clinical and laboratory research suggest that the adverse changes may be inter-related and have a common origin in fetal life or childhood.Exposure of the male fetus to supranormal levels of estrogens, such as diethlylstilbestrol, can result in the above-mentioned reproductive defects.The growing number of reports demonstrating that common environmental contaminants and natural factors possess estrogenic activity presents the working hypothesis that the adverse trends in male reproductive health may be, at least in part, associated with exposure to estro- genic or other hormonally active (e.g., antiandrogenic) environmental chemicals during fetal and childhood development.An extensive research program is needed to understand the extent of the problem, its underlying etiology, and the development of a strategy for prevention and inter- vention.
Celebration of Dermatology, Saturday 10 July 1993
Journal: British Journal of Dermatology (1993)

British Journal of DermatologyVolume 129, Issue s42 p. 71-71 Celebration of Dermatology, Saturday 10 July 1993 First published: July 1993 https://doi.org/10.1111/j.1365-2133.1993.tb03370.xAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume129, Issues42July 1993Pages 71-71 RelatedInformation
Influenza Activity—United States, 1999-2000 Season
Journal: JAMA (1999)

DURING 1996-1998, CDC RECEIVED REports from approximately 16 state health departments of Salmonella infections in persons who had direct or indirect contact with reptiles (i.e., lizards, snakes, or turtles).Salmonella infection can result in invasive illness including sepsis and meningitis, particularly in infants.Despite educational efforts, some reptile owners remain unaware that reptiles place them and their children at risk for salmonellosis.This report summarizes clinical and epidemiologic information in four cases and provides information about state regulations to prevent transmission of Salmonella spp.from reptiles to humans. Case ReportsArizona.During October 1996, a 3-week-old boy was admitted to a hospital emergency department with fever (103.6 F [40 C]), vomiting, and bloody diarrhea of 15 days' duration.Stool and blood cultures yielded Salmonella serotype IV 44:z 4 ,z 23-, an extremely rare serotype.The infant was hospitalized for 10 days and treated with intravenous fluids and amoxicillin.To determine the cause of the infant's illness, a stool specimen was obtained from the family's pet iguana, which also yielded Salmonella IV 44: z 4 ,z 23-.In an attempt to prevent reinfection, local health officials informed the parents of the importance of the infant avoiding direct and indirect contact with the reptile, and the iguana was moved to a relative's home.One month
ANTISTREPTOCOCCUS SERUM.
Authors: HOWARD LILIENTHAL
Journal: JAMA (1900)

Three years ago I reported my impressions of the efficacy of antistreptococcus serum based on experience with 5 or 6 cases. In some of these the presence of the streptococci in the wound-discharges had been demonstrated, and in others staphylococci had been found both in the discharges and in the blood on culture. At that time my conclusion was that the serum rarely if ever did harm, and that in desperate cases the patient should be given the benefit of this treatment in connection with other and better known therapeutic measures. Further acquaintance with the subject has not caused me to modify the views I then held, though the percentage of recoveries due, apparently, to the employment of the remedy has not been encouraging. Several cases in which there were clinical symptoms of the severest type of sepsis seemed to yield to the serum treatment instituted before it was possible
Principles of Species Adjustment I. Continuous Exposure
Journal: JNCI Journal of the National Cancer Institute (1943)

Principles of Species Adjustment I. Continuous Exposure Get access R. R. Spencer, R. R. Spencer chief National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar M. B. Melroy M. B. Melroy assistant bacteriologist National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 4, Issue 3, December 1943, Pages 249–256, https://doi.org/10.1093/jnci/4.3.249 Published: 01 December 1943
Severe toxic reactions and death following the ingestion of diethyltoluamide-containing insect repellents
Authors: M. Tenenbein
Journal: JAMA (1987)

<i>N,N</i>-diethyl-<i>m</i>-toluamide (DEET) is the most commonly used mosquito repellent. This report describes five cases of toxic reactions after ingestion of insect repellents containing DEET. Each patient ingested large amounts of concentrated (47.5% to 95%) products. Their common symptoms and signs were coma, seizures, and hypotension occurring within one hour of ingestion. Two patients died; three survivors had no sequelae. The two patients who died had serum DEET levels of 0.88 mmol/L (16.8 mg/dL) and 1.25 mmol/L (24 mg/dL). It is concluded that the ingestion of DEET can produce severe toxic reactions of rapid onset that may be fatal in some instances. (<i>JAMA</i>1987;258:1509-1511)
Cause of Death
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
4O VHIO immune gene expression profiling (VIGex) panel, a tool to explore tumor immune microenvironment
Authors: F.M. Mancuso, Z. Ogbah, R. Fasani, D. Lo Giacco, L. Ramos, A. Oaknin, M. Alsina, E. Élez, T. Macarulla Mercade, C. Saura, J. Capdevila, M. Vieito Villar, E. Felip, R. Dienstmann, A. Gros, J. Seoane, P.G. Nuciforo, J. Tabernero, E. Garralda, A. Vivancos
Journal: Annals of Oncology (2020)
Abstract 1395: Role of High Mobility Group Box 1 Protein in Post-Infarction Healing Process and Left Ventricular Remodeling
Authors: Takashi Kohno, Toshihisa Anzai, Tsutomu Yoshikawa, Kotaro Naito, Koji Ueno, Taku Miyasho, Minoru Okamoto, Shingo Yamada, Akitoshi Ishizaka, Satoshi Ogawa
Journal: Circulation (2007)

Background: The appropriate infarct healing process is prerequisite for preventing left ventricular (LV) remodeling after myocardial infarction (MI). High mobility group box1 protein (HMGB1) is derived from necrotic cells and activated macrophages and involved in tissue repair as immunostimulatory signal. However, the role of HMGB1 in post-MI LV remodeling is unknown. Methods and Results: We examined 35 patients with first ST-elevated acute MI. Peak serum HMGB1 level, determined by serial measurements (q. 6h), did not differ in age, sex, coronary risk factors and infarct site. Its peak level was markedly higher in patients with adverse in-hospital clinical outcomes, including pump failure, cardiac rupture, LV aneurysm and cardiac death, compared with those without (all p&lt;0.05). Then we performed experimental study using rat MI model, induced by permanent left coronary ligation. Anti-HMGB1 antibodies (1 mg/day, MI/antiH, n=20) or control antibodies (MI/C, n=20) were injected subcutaneously every 24 hours for 7 days. Sham-operated rats served as controls (n=10). Quantitative RT-PCR and immunoblotting showed that HMGB1 expression was increased in the infarcted area peaking at day 3 in MI/C compared with sham (p&lt;0.05). Its expression was localized in myocytes and inflammatory cells by immunohistochemistry. The mRNA level of TNF-α (−48%, p=0.03) and IL1-β (−44%, p=0.02) and the number of infiltrated macrophages (p=0.04) in the infarcted area were markedly reduced at day 3 in MI/antiH compared with MI/C. Echocardiographic and hemodynamic studies at day 7 showed increased LV end-diastolic dimension (p=0.03), LVEDP (p=0.03), and decreased LV max dP/dt (p=0.01) in MI/antiH compared with MI/C. Histologically, scar thinning in the infarcted area (0.53±0.23 vs 0.68±0.21 mm, p=0.02) and hypertrophy in the non-infarcted myocardium (2.01±0.23 vs 1.63±0.21 mm, p=0.03) were more prominent in MI/antiH compared with MI/C at day 14. Conclusions: Elevation of serum HMGB1 level is associated with adverse clinical outcomes in patients with acute MI. However, blockade of HMGB1 in rat MI model aggravated early LV remodeling through impaired infarct healing and advanced scar thinning, suggesting an essential role of HMGB1 in the appropriate repairing process after MI.
ROYAL SOCIETY OF MEDICINE
Authors: J. E. M. Wigley
Journal: British Journal of Dermatology (1949)

Journal Article ROYAL SOCIETY OF MEDICINE Get access J. E. M. Wigley J. E. M. Wigley President Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 61, Issue 8-9, 1 August 1949, Pages 288–302, https://doi.org/10.1111/j.1365-2133.1949.tb11103.x Published: 01 August 1949
Congress and Public Health.
Journal: JAMA (1885)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal