tbuckley/cabot-search huggingface dataset:
Scintigraphic appearance of Anton's syndrome
Authors: J. V. Cusumano
Journal: JAMA (1981)

THE DIAGNOSIS of Anton's syndrome was confirmed by a radionuclide brain scan in an elderly man with blindness and agnosia. <h3>Report of a Case</h3> An 86-year-old man was admitted to a hospital after driving his automobile into a ditch. Although there were no apparent injuries from the accident, except a laceration of his forehead, the patient was blind. He appeared to be normotensive, was orientated only to other persons, was unable to distinguish between light and darkness, and had normal extraocular movements; his pupils were reactive to light directly and consensually. The patient appeared to be unaware of his loss of vision. When confronted by his examiners, he would reply that someone had turned off the lights in the room or that he was still asleep. In addition to blindness and a slightly decreased sensation to pinpricks and vibration in both distal lower extremities, the patient had lost stereognosis and
P29: Routine screening with early‐morning cortisol facilitates identification and improves management of adrenal insufficiency in glucocorticoid‐treated dermatology patients
Authors: F Ali
Journal: British Journal of Dermatology (2021)

profile led to dupilumab receiving European Medicines Agency approval without mandated laboratory monitoring.The increase may reflect clinicians' cautious approach in administering treatment to an atypical hospital-treated patient population, and may attenuate over time with increasing clinician confidence and disease control.Indeed, over a third of the healthcare resource use was linked to treatment administration, suggesting costs savings with homecare administration.
Program of the Woman's Auxiliary
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sports Medicine
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Croonian Lectures on the Numerical Method, and its Application to the Science and Art of Medicine
Authors: W. A. Guy
Journal: BMJ (1860)

Thou(qh lcrge numbers of Facts are necessary for Scientific Discorery, and for Practical Application to Individual Cases, it is allowable to use Smaller Numbers of Facts for certain P'urposes.Our Facts should be numerous, because they differ widely from each other.The Population of England and Wales taken as an Example; and the Houses and Ships which we insure against Fire and JVreck.The Analogy of Games of Chance.Parallel Groups of Averages compared.The Ages at Death of the English Aristocracy, antd of the Upper and Middle Classes in England, and the Attendances at King's College Hosrital, used to prove the Divergence of the Groups when tile Facts are fetv, and their Convergence when the Facts are numerous.The Mode of Approximation shown in the Case of the Temperathres of different Years.The Births of Male and Female Children in England and W7ales, in Populations of different Sizes, used to illustrate the same Truth.What Number of Facts sufficient in any given Inquiry ?Mathematical IForntil1ce in Use for this Purpose.IN all the observations which I have hitherto made on the numerical method-on the logic, that is to say, of average and extreme values-I have assumed that our averages and ex- tremes are obtained from a considerable body of facts.When our object is to ascertain any great scientific truth, or to make safe application of average results to a large number of similar individual instances, we must work with large bodies of facts.
Identification of Functional Polymorphisms in the Promoter Region of the Human PICK1 Gene and Their Association With Methamphetamine Psychosis
Authors: Daisuke Matsuzawa
Journal: American Journal of Psychiatry (2007)

Objective: Protein interacting with C-kinase-1 (PICK1) plays a role in the targeting and clustering of dopamine transporter, which is the primary target site for the abused drug methamphetamine. Based on the interaction of PICK1 with dopamine transporter, it is of particular interest to investigate the association between the PICK1 gene and methamphetamine abusers. Method: The authors studied the association between PICK1 gene polymorphisms and methamphetamine abusers in a Japanese group. Two hundred and eight methamphetamine abusers and 218 healthy comparison subjects were enrolled in the study. Furthermore, the authors also examined the effects of single nucleotide polymorphisms (SNPs) in the promoter and 5′-untranslated region on transcription levels of PICK1. Results: The authors identified four highly frequent SNPs, rs737622 (–332 C/G) and rs3026682 (–205 G/A) in the promoter region and rs713729 (T/A) in intron3 and rs2076369 (T/G) in intron4. Of these SNPs, rs713729 was significantly associated with methamphetamine abusers in general, and rs713729 and rs2076369 were significantly associated with those with spontaneous relapse of psychosis. Furthermore, haplotype analysis revealed that specific haplotypes of these SNPs were associated with methamphetamine abusers. A gene reporter assay revealed that the two SNPs in the promoter region significantly altered transcriptional activity. Conclusions: Our findings suggest that the PICK1 gene may be implicated in the susceptibility to spontaneous relapse of methamphetamine psychosis and that, as an intracellular adapter protein, PICK1 may play a role in the pathophysiology of methamphetamine psychosis.
Spasmodic Dysphonia
Authors: DAVID E. HARTMAN
Journal: Annals of Internal Medicine (1984)

Letters and Corrections1 September 1984Spasmodic DysphoniaDAVID E. HARTMAN, PH.D., BALAJI VISHWANAT, M.D.DAVID E. HARTMAN, PH.D.Search for more papers by this author, BALAJI VISHWANAT, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-101-3-403_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In the April issue, Feldman and coworkers (1) have identified some new and important characteristics of one form of spasmodic dysphonia. A number of their findings warrant further discussion.Voice arrest and strained vocal quality due to vocal fold hyperadduction are frequently the primary features of psychogenic dysphonia. The fact that a specific underlying abnormality cannot be identified in spasmodic dysphonia does not mean that certain forms of the disorder do not have an underlying psychogenic cause. It is conceivable, and indeed an accepted tenet by some (2), that the dysphonia may be based on long-standing rather...References1. FELDMAN M, NIXON J, FINITZO-HIEBER T, and FREEMAN F. Abnormal parasympathetic vagal function in patients with spasmodic dysphonia. Ann Intern Med. 1984;100:491-5. LinkGoogle Scholar2. ARONSON A. Neurologic and psychiatric aspects of adductor spastic dysphonia and the effects of recurrent laryngeal nerve resection. In: Transcripts of the 12th Symposium on Care of the Professional Voice. New York: Voice Foundation; 1983:1984-91. Google Scholar3. HARTMAN D. Neurogenic dysphonia. Ann Otol Rhinol Laryngol. 1984;93:57-64. CrossrefMedlineGoogle Scholar4. ARONSON A and HARTMAN D. Adductor spastic dysphonia as a sign of essential (voice) tremor. J Speech Hear Dis. 1981;46:110-6. MedlineGoogle Scholar5. BANNISTER R, GIBSON W, MICHAELS L, and OPPENHEIMER D. Laryngeal abductor paralysis in multiple system atrophy. Brain. 1981;104:351-68. CrossrefMedlineGoogle Scholar6. HARTMAN D and ARONSON A. Clinical investigations of intermittent breathy dysphonia. J Speech Hear Dis. 1981;46:428-32. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DAVID E. HARTMAN, PH.D.; BALAJI VISHWANAT, M.D.Affiliations: Gundersen Clinic, Ltd. 1836 South Avenue; La Crosse, WI 54601 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1984Volume 101, Issue 3Page: 403-403 ePublished: 1 December 2008 Issue Published: 1 September 1984 PDF downloadLoading ...
Association News.
Authors: George H. Simmons
Journal: JAMA (1900)

<h3>Annual Announcement.</h3> The fifty-first annual session (53d year) of theAmerican Medical Associationwill be held in Atlantic City, N. J., on Tuesday, Wednesday, Thursday and Friday, June 5, 6, 7 and 8, commencing on Tuesday at 11 a. m. <h3>REGARDING REPRESENTATION.</h3> The delegates shall receive their appointment from permanently organized State medical societies, and such county and district medical societies<i>as are recognized by their respective State societies</i>, and from the medical departments of the Army and Navy and the Marine-Hospital Service of the United States. Each State, county and district medical society entitled to representation shall have the privilege of sending to the Association one delegate for every ten of its regular resident members, and one for every additional fraction or more than half that number;<i>Provided</i>, however, that the number of delegates from any particular State, Territory, county, city or town shall not exceed the ratio of
Sulfasalazine Toxic Reactions
Authors: Anastasios A. Mihas, David J. Goldenberg, Robert L. Slaughter
Journal: JAMA (1978)

SINCE its discovery in 1942, sulfasalazine (Azulfidine) has been the most commonly used sulfonamide for the treatment of inflammatory bowel disease. Its merit has been well established in ulcerative colitis, and it possibly has a place in the treatment of Crohn's disease. Although minor adverse effects (anorexia, nausea, vomiting) are recognized frequently, serious reactions are considered rare. In recent years, however, severe adverse reactions to sulfasalazine therapy have been reported with greater frequency.<sup>1,2</sup>We report a generalized allergic reaction with fever, skin rash, arthralgias, lymphadenopathy, and hepatitis coincident with the administration of this drug. This reaction was accompanied by decreased complement levels and circulating immune complexes. <h3>Report of a Case</h3> A 26-year-old man was seen because of a three-year history of intermittent cramping abdominal pain, diarrhea, and a 9-kg weight loss. A sigmoidoscopy, small bowel series, and barium enema examination showed Crohn's disease involving the terminal ileum and rectum.
Test-Retest Reliability of a Functional MRI Working Memory Paradigm in Normal and Schizophrenic Subjects
Authors: D. S. Manoach
Journal: American Journal of Psychiatry (2001)

OBJECTIVE: Repeated functional magnetic resonance imaging (fMRI) studies of schizophrenic subjects may identify brain activity changes in response to interventions. To interpret the findings, however, it is crucial to know the test-retest reliability of the measures used. METHOD: The authors scanned seven normal subjects and seven schizophrenic subjects on two occasions during performance of a working memory task. They quantified the reliability of task performance and brain activation. RESULTS: In both groups, task performance was reliable, and all a priori regions were activated in group-averaged test and retest data. In individual schizophrenic subjects, however, indices of cognitive activation were not reliable across sessions. Normal subjects showed reasonable reliability of activation. CONCLUSIONS: Even given reliable task performance, stable clinical status, and a stable pattern of group-averaged activation, individual subjects showed unreliable brain activation. This suggests that repeated fMRI studies of schizophrenia should control for sources of variation, both artifactual and intrinsic.
Diethylstilbestrol in Breast Cancer: Dose-Response Analysis
Authors: Richard J. Kaufman
Journal: JAMA (1977)

<h3>To the Editor.—</h3> Carter et al have recently published in this journal (237:2079, 1977) the results of a cooperative, prospective, double-blind study that attempted to assess the role of diethylstilbestrol (DES) in the treatment of postmenopausal women with metastatic breast cancer. These investigators studied the dose-response characteristics of this drug over a fourlog dosage range. The data obtained in the study, when analyzed according to a mathematical model of doseresponse, led to the following conclusions: The response rate to DES is a function not only of the dose but also of menopausal age and dominant site of metastases. However, the results within menopausal age group and within dominant metastatic site category do not conform to a simple, uniformly increasing dose-response relationship. In particular, for the postmenopausal age group of ≥5 and ≤10 years the analysis led to a complex relationship in which the "best treatment" varied according to site
Immunology
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Somatostatin
Authors: Seymour Reichlin
Journal: New England Journal of Medicine (1983)

DURING the course of efforts to determine the distribution of growth hormone–releasing factor (GHRF) in rat hypothalamus, a substance that inhibited growth hormone release was unexpectedly detected by Krulich et al.1 Their findings, reported in 1968, led them to hypothesize that the secretion of growth hormone from the pituitary was regulated by two different, interacting neurohumoral factors — one stimulatory, the other inhibitory — each under the control of the nervous system. Their hypothesis has since been substantiated by more specific methods. At about the same time, Hellman and Lernmark found a factor in extracts of pigeon pancreatic islets that . . .
不同特应性皮炎定义的影响
Authors: T. Nakamura, S. Haider, S. Colicino, C.S. Murray, J. Holloway, A. Simpson, P. Cullinan, A. Custovic
Journal: British Journal of Dermatology (2019)

特应性皮炎(AD)是最常见的皮肤病之一, 但没有单一术语来定义此病。尽管 AD 是此病目前最常使用的名称,其他名称(如湿疹)也常用。这可能导致难以比较不同研究之间的结果和了解真实的疾病负担。 我们发现, 不同国家和不同医学专业的研究者们使用不同的名称(AD 或湿疹), 但这两个名称并不始终涉及相同的疾病。我们之后调查了在他们的研究中, 如果研究人员使用相同的名称 (AD), 但以略微不同的方式定义,是否会得到不同的结果和不同的结论。 为此, 我们首先回顾了医学文献, 以找出研究人员定义 AD 的最常见方式。我们在回顾的 45 项研究中发现了令人难以相信的 59 种不同定义。我们之后选择了 4 种最常使用的定义,将它们应用到英国 2 个出生队列中的 >1000 名儿童(出生在相同的时间段中)身上。 使用这些不同的定义导致被贴上 AD 标签儿童的数量(此病所谓的患病率)出现显著差异,以及基因和其他风险因素对于此病重要性评估的差异。 作者们得出结论, 目前亟需一个此病常用且普遍接受的定义,以充分了解其对患者、患者家人和社会的影响, 和确定不同基因和环境暴露的重要程度。
PRESIDENTIAL ADDRESS
Authors: ROGER I.  LEE
Journal: Annals of Internal Medicine (1942)

Article1 July 1942PRESIDENTIAL ADDRESSROGER I. LEE, M.D., F.A.C.P.ROGER I. LEE, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-17-1-1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThis Annual Session of the American College of Physicians, this Convocation is a significant demonstration of the determining philosophy upon which the College is founded. Others may speak of the education and training in the professions of religion, teaching, engineering, the law, business, etc., but in the profession of medicine, and particularly in the medical specialties of which our College is a noteworthy illustration, it seems desirable to discuss from time to time certain outstanding features. As a preface to this discussion one may recall the emphasis that the late Charles W. Eliot, then President of Harvard University, put upon... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Address at the Annual Convocation of the American College of Physicians, St. Paul, Minnesota, April 22, 1942. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1942Volume 17, Issue 1Page: 1-4KeywordsMedical education ePublished: 1 December 2008 Issue Published: 1 July 1942 Copyright & PermissionsCopyright, 1942, by The American College of PhysiciansPDF downloadLoading ...
The Beat
Authors: Erin E. Dooley
Journal: Environmental Health Perspectives (2013)

A New Lighting Alternative?Wake Forest University engineers are using multiwalled carbon nanotubes to enhance the brightness of field-induced polymer electroluminescent technology, potentially offering a step forward in the search for safe, pleasing, high-efficiency lighting. 1In this technology, moldable polymer matrix emits light when exposed to an electrical current.It could eventually yield high-efficiency lights without the mercury vapor of compact fluorescent lamps or the bluish tint of some fluorescents and LEDs, which has been linked with circadian rhythm disruption. 2
Elevated levels of factor VIII:C in patients with atrial flutter and decreased left ventricular function Bengt Herweg, Maryam Ziaie Matin, Raja'a M. Kaddaha, Frederick A. Ehlert, Margot E. Vloka, Alice J. Cohen, Jonathan S. Steinberg. St, Luke's-Roosevelt Hospital Center and Columbia University, New York, NY, Newark Beth Israel Medical Center, Newark, NJ
Journal: Journal of the American College of Cardiology (2001)
Coronary Turncoat
Authors: William B. Hood
Journal: New England Journal of Medicine (1976)

Renegade vascular smooth muscle is either culprit or accomplice in causing a variety of human ills — essential hypertension, primary pulmonary hypertension and Raynaud's disease, to name a few. In recent years it has become apparent that the muscular coat of the medium-sized proximal coronary arteries, those usually involved with coronary atherosclerosis, may also join in this vascular rebellion, and cause coronary insufficiency through the mechanism of vasospasm.Much of the credit for identifying this disease belongs to Prinzmetal, who in 1959 described a remarkable series of patients in whom chest pain, anginal in nature, occurred at rest, but usually . . .
MEDICINE.
Journal: JAMA (1883)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Markedly enhanced susceptibility to experimental autoimmune myasthenia gravis in the absence of decay-accelerating factor protection
Authors: Feng Lin, Henry J. Kaminski, Bianca M. Conti-Fine, Wei Wang, Chelliah Richmonds, M. Edward Medof
Journal: Journal of Clinical Investigation (2002)

Myasthenia gravis (MG) is an autoimmune neuromuscular transmission disorder characterized by loss of acetylcholine receptors (AChR's) due primarily to the production of anti-AChR autoantibodies. In this study we investigated whether the presence of decay-accelerating factor (DAF or CD55), an intrinsic complement regulator, protects against the development of disease. Experimental autoimmune MG was induced in Daf1–/– mice (devoid of neuromuscular DAF protein) and their Daf1+/+ littermates by injection of rat anti-AChR mAb McAb-3. After twenty-four hours, grip strength assessment revealed that Daf1–/– mice exhibited hold times of less than 30 seconds, compared with more than 8 minutes for the Daf1+/+ controls. The weakness was reversed by edrophonium, consistent with a myasthenic disorder. Immunohistochemistry revealed greatly augmented C3b deposition localized at postsynaptic junctions, and radioimmunoassays showed more profound reductions in AChR levels. Electron microscopy demonstrated markedly greater junctional damage in the Daf1–/– mice compared with the Daf1+/+ littermates. Control studies showed equivalent levels of other cell surface regulators, i.e., Crry and CD59. The results demonstrate that mice that lack DAF are markedly more susceptible to anti-AChR–induced MG, which simulates the primary mechanism in the human disease, and strongly suggest that in disease flares complement inhibitors might have therapeutic value.