tbuckley/cabot-search huggingface dataset:
Ileostomy and excisional surgery for chronic inflammatory disease of the colon: A survey of one hospital region: Part II The health of ileostomists
Journal: Gut (1971)

Part II The health of ileostomistsAbstract To the ileostomist who asks, `Am I as healthy as the rest of the population', the answer can be a qualified affirmative. There is probably an increased likelihood of his developing calculi in the urinary tract but, apart from this, there is no suggestion of diseases of a general nature to which he is more subject than another individual of comparable age. If the surgery has been undertaken for ulcerative colitis in the absence of malignant change and the patient has survived one postoperative year, then an assurance can be given that life expectancy is little less than that in the general population.
Powerful Prions?
Authors: Bernard N. Fields
Journal: New England Journal of Medicine (1987)

An important landmark in our conception of viruses was the recognition that viruses can cause diseases that present none of the hallmarks of classic infectious diseases. Perhaps the most extraordinary example of this atypical behavior of "viruses" is exemplified by the group of slow viruses recently termed "prions" by Prusiner and his colleagues and reviewed in this issue of the Journal.1 Veterinarians originally recognized that certain viral diseases such as visna-maedi and scrapie could have very long incubation periods, cause no fever or inflammatory response, and fail to lead to an immune response.2 The similarities between the neuropathologic process . . .
Exposure of Cotton Workers in an Experimental Cardroom with Reference to Airborne Endotoxins
Authors: Ragnar Rylander, Per Haglind
Journal: Environmental Health Perspectives (1986)

Workers from cotton mills were exposed to cotton dust during carding in an experimental cardroom. Cotton from different geographical locations with varying amounts of endotoxin were used. Exposure levels ranged from 0.6 to 3.6 mg dust/m3 (from a vertical elutriator) and from 0.1 to 8.0 micrograms/m3 of endotoxin. No relationship was found between the decrease in FEV1 over the workshift and the amount of airborne dust. Airborne endotoxin correlated with the decrease in FEV1 and the increase in blood neutrophils. The FEV1 decrease was more pronounced among smokers. The data suggest that the amount of airborne endotoxin determines the risk for development of the acute symptoms in the byssinosis syndrome.
Joint Statement on Antisubstitution Laws and Regulations
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE BACTERIAL SELF-PURIFICATION OF STREAMS.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
HYPOGLYCEMIA AND RECURRENT VOMITING
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Intestinal Barriers to Water-Soluble Macromolecules
Authors: James G. Lecce
Journal: Environmental Health Perspectives (1979)

Neonates of some species of mammals absorb water-soluble macromolecules from the lumen of the gut to the circulation. This is a means for providing the neonate with passive immunological protection. The accepted model for absorption of macromolecules, particularly immunoglobulin G (IgG), has at least three phases: adherence of the macromolecule to the brush border on enterocytes; internalization of the macromolecule within the enterocytes; and egress of the macromolecule into the lamina propria. With regard to the absorption of IgG, adherence is thought to be a specific reaction of ligand (IgG) with a plasmalemma binding site. Pinocytosis is activated and internalization follows. Egress into the lamina propria occurs at the basal-lateral membrane by a process of reverse pinocytosis. Unbound (unprotected) macromolecules that are internalized in the pinocytosic fluid are shunted off to lysosomes and either digested or stored therein. Neonatal rodents fit this model for macromolecular absorption. However, in another group of neonates (e.g., pig, cow, horse), nonselected absorption takes place, in that IgG and other macromolecules are transported from the gut lumen to the blood. In a third group of neonates, (e.g., human, guinea pig) absorption of IgG is either of low order or nonexistent. Since neonatal mammals possess a mechanism for absorbing macromolecules, there is the potential for internalizing toxic macromolecules if the toxin is presented to the neonate's enterocytes in competitive amounts. Adults retain remnants of the neonatal absorptive mechanism.
Acknowledgments to assessors in 1992
Journal: Annals of the Rheumatic Diseases (1993)

Matters arising/Correction unable to protect the stomach; on the other hand, misoprostol, while affording good protection of both gastric and duodenal mucosa, causes frequent side effects on the intestinal tract.2The conclusions of Taha and Sturrock, however, must be accepted with caution.First of all in a recent paper on the subject they admitted that there was no significant difference in the prevalence of endoscopic abnormalities among patients taking NSAIDs alone or NSAIDs plus gold if the size of such lesions was not taken into consideration.3The relation between the claimed gastroprotective properties of gold and Helicobacter pylon infection is also unproved.The role of H pylori in NSAID gastropathy is still debated, but most studies deny that the microorganism can promote or worsen NSAID injury.2 4The evidence quoted by Taha and Sturrock in favour of an inhibitory effect of gold on H pylori is mostly based on reports which have appeared only as abstracts.Full length papers provide conflicting data.4 5 Taha and Sturrock mention a possible
Aspects of the Toxicology of Chloroprene: Immediate and Long-Term Effects
Authors: I. V. Sanotskii
Journal: Environmental Health Perspectives (1976)

The maximum permissible concentration (MPC) of chloroprene was set at 2 mg/m3 in the USSR in the 1940's. The existing MPC is 4 mg/m3. The threshold of systemic effects as a result of chronic chloroprene exposure is l.69 mg/m3. However, the threshold for embryotoxic and mutagenic effects is 0.15 mg/m3. In consideration of this information, setting a new MPC for chloroprene at 0.05 mg/m3 is recommended.
Glucose-Dependent Insulinotropic Polypeptide Receptor Therapies For The Treatment Of Obesity, Do Agonists = Antagonists?
Authors: Elizabeth A Killion, Shu-Chen Lu, Madeline Fort, Yuichiro Yamada, Murielle M Véniant, David J Lloyd
Journal: Endocrine Reviews (2019)

Abstract Glucose-dependent insulinotropic polypeptide (GIP) receptor (GIPR) is associated with obesity in human genome-wide association studies (GWAS). Similarly, mouse genetic studies indicate that loss of function alleles and GIP overexpression both protect from high-fat diet (HFD)-induced weight gain. Together, these data provide compelling evidence to develop therapies targeting GIPR for the treatment of obesity. Further, both antagonists and agonists alone prevent weight gain, but result in remarkable weight loss when co-dosed or molecularly combined with glucagon-like peptide-1 (GLP-1) analogs preclinically. Here, we review the current literature on GIPR, including biology, human and mouse genetics, and pharmacology of both agonists and antagonists, discussing the similarities and differences between the two approaches. Despite opposite approaches being investigated preclinically and clinically, there may be viability of both agonists and antagonists for the treatment of obesity and we expect this area to continue to evolve with new clinical data and molecular and pharmacological analyses of GIPR function.
ITALY
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Carcinoma Arising in a Rectal Duplication (Enterocystoma)
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Takotsubo Cardiomyopathy
Authors: Abhishek Maiti, Abhijeet Dhoble
Journal: New England Journal of Medicine (2017)

A 61-year-old woman presented to the emergency department with chest pain. ST-segment elevations were revealed on ECG. A coronary angiogram showed normal coronary arteries, but left ventriculography and echocardiography revealed takotsubo cardiomyopathy (shown in videos).
The optimal intensity of oral anticoagulant therapy
Authors: J. Hirsh
Journal: JAMA (1987)

IN THE United States, approximately 500 000 patients per year receive oral anticoagulant therapy (R. Hart, MD, quoting J. Wallner, Product Manager, Dupont Pharmaceuticals, Wilmington, Del, oral communication, April 1986). Since Quick et al<sup>1</sup>introduced their test in 1935, it has been traditional to use the one-stage prothrombin time (PT) to monitor warfarin therapy. This test, which is sensitive to three of the four vitamin K-dependent clotting factors, is performed by adding a phospholipid extract of mammalian tissue (known as thromboplastin) to citrated plasma and clotting the mixture by adding calcium. Many clinicians who prescribe oral anticoagulants might be surprised to learn that the dose of warfarin that we currently use to prolong the PT to a ratio of 2 to 2.5 times the control value is larger than the dose that was used to produce an identical prolongation of the PT in the 1940s, 1950s, and the 1960s.
Looking at Cancer
Authors: J. W. Berg
Journal: CA A Cancer Journal for Clinicians (1961)

The progress of metastatic breast cancer often can be slowed by adrenalec tomy.Treatment would be simpler and more widely available if cortisone or some similar compound could produce a functionally equivalent state.Unfortu nately, as Dao and his coworkers from Ros@vell Park Memorial Institute show, this just does not happen.In a random study, objective responses were seen in almost half the surgically treated patients, but in none of those treated by hor mones.This of course contradicts previous favorable reports on cortisone but the authors account for the difference on the basis of their truly strict criteria for response.They demanded substantial regression, not just of skin nodules, but of the visceral lesions that limit the patient's comfort and function.
Abstract 224: Antibody-drug conjugates (ADCs) of a new class of N-10 amino linked DNA alkylating indolino-benzodiazepines (IGNs)
Authors: Michael L. Miller, Emily E. Reid, Katie E. Archer, Luke Harris, Erin K. Maloney, Laura M. Bartle, Olga Ab, Alan J. Wilhelm, Jose F. Ponte, Rajeeva Singh, Thomas A. Keating, Ravi V. Chari
Journal: Cancer Research (2019)

Abstract We have previously reported on our antibody-drug conjugates (ADCs) that incorporate a highly potent novel DNA alkylating indolino-benzodiazepine (termed IGN) dimer. ADCs of these DNA alkylating IGNs were found preclinically to demonstrate better tolerability and an improved overall therapeutic index (TI) compared with those of the corresponding DNA crosslinking IGNs (Miller, et al., Mol. Cancer Ther. 2016, 2018). IGN-containing ADCs that have reached the clinical stage bear DNA alkylating IGN compounds linked to the antibody via a cleavable linker, incorporated at the amino group of a centrally located anilino spacer moiety. In our ongoing effort to further explore the structure-activity relationship (SAR) of DNA alkylating effector molecules for ADCs, we disclose here a new class of IGNs possessing a self-immolative peptide linker attached at the N-10 amine of the imine-reduced IGN monomer subunit. We explored the impact of modifying the central spacer group connecting the IGN monomers, and site of linkage on in vitro potency and the interaction with DNA. A set of IGN molecules that met our potency criteria were identified and linkable forms of these compounds were prepared and conjugated to a folate receptor-α (FRα)-binding antibody. These ADCs displayed potent, antigen-specific in vitro activity across a panel of FRα-expressing cell lines. A lead ADC selected for in vivo studies demonstrated high stability in plasma and potent efficacy in various xenograft models, at doses well below the maximum tolerated dose. Thus, IGNs modified with an N-10 self-immolative peptide linker are promising DNA alkylating effector molecules for use in ADCs. Citation Format: Michael L. Miller, Emily E. Reid, Katie E. Archer, Luke Harris, Erin K. Maloney, Laura M. Bartle, Olga Ab, Alan J. Wilhelm, Jose F. Ponte, Rajeeva Singh, Thomas A. Keating, Ravi V. Chari. Antibody-drug conjugates (ADCs) of a new class of N-10 amino linked DNA alkylating indolino-benzodiazepines (IGNs) [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 224.
Apnea during treatment with sodium colistimethate
Authors: A. F. Parisi
Journal: JAMA (1965)

RESPIRATORY PARALYSIS has been increasingly publicized as a side effect encountered in antibiotic therapy. Recently Perkins<sup>1</sup>incriminated sodium colistimethate, a congener of polymyxin B, as a cause of apnea in man. We have observed a patient who experienced respiratory arrest during colistimethate therapy and have obtained additional data pertinent to the interrelationship. <h3>Report of a Case</h3> A 66-year-old woman had intermittent, severe acute pyelonephritis for four years prior to November 1963, when she underwent right nephrectomy for multiple cortical abscesses. At that time chemical diabetes was discovered. In December 1963. she was readmitted with left pyelonephritis. On examination she was in a toxic condition and dehydrated. Temperature was 101.4 F (38.6 C), pulse rate 92, and blood pressure 120/80 mm Hg. Carotid pulses were normal. She had a grade 2/6 systolic ejection murmur at the left sternal border and a healed right flank incision. Neurological examination showed intact cranial
Miscellany.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SHALL CONSUMPTIVES MARRY?
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Elevated fasting blood glucose in non-diabetics predicts clinical restenosis: A prospective study of 2,246 patients with severe coronary artery disease Chloe A. Allen Maycock, Joseph B. Muhlestein, Dale G. Renlund, Benjamin D. Horne, Tami L. Bair, Kirti Salunkhe, Farangis Lavasani, Jeffrey L. Anderson. LDS Hospital, Salt Lake City, UT, University of Utah, Salt Lake City, UT
Journal: Journal of the American College of Cardiology (2001)
LETTER FROM A. B. TADLOCK, PRESIDENT TENNESSEE STATE MEDICAL SOCIETY.
Journal: JAMA (1883)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal