tbuckley/cabot-search huggingface dataset:
Deployment to the Iraq War and Neuropsychological Sequelae
Authors: Charles W. Hoge
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical Endocrinology of the Female.
Authors: Herbert Bruce, Mrs Bruce, Stuart Pritchard Of Battle Creek, J Elliott
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 2007: Validation of a preclinical model for bone metastatic triple negative breast cancer
Authors: Justyna Zdrojewska, Mari I. Suominen, Katja M. Fagerlund, Jussi M. Halleen, Jenni Bernoulli, Johann Zimmermann
Journal: Cancer Research (2019)

Abstract Metastatic breast cancer (MBC) is the most advanced stage of breast cancer, diagnosed as stage IV. Typically, MBC metastases occur in the bones, liver, brain, and lungs. Bone metastases cause significant morbidity and mortality in late-stage breast cancer patients. At present, there is no efficient curative or preventive treatment for bone metastases. Therefore, establishment and validation of well characterized in vivo models of breast cancer bone metastasis is of utmost importance. The aim of this study was to validate an intracardiac model of bone MBC utilizing GFP tagged triple negative (estrogen receptor; ER, progesterone receptor; PR and human epidermal growth factor receptor 2; HER2 negative) human breast cancer cells, which could be used to study efficacy of new potential treatments. Female athymic nude mice (Hsd: Athymic Nude-Foxn1nu) were used in this study. Bone seeking MDA-MB-231(SA)-GFP human breast cancer cells were inoculated into the left cardiac ventricle of 4-6 weeks old female mice. Allocation to treatment groups (n=15) was performed by stratification procedure based on animal weight prior to the beginning of the study. To validate the model, the current standard-of-care (SOC) treatment (Paclitaxel) was administered between study days 13-17 at the therapeutic dose. Serum bone biomarker TRACP5b was measured before cancer cell inoculation and at sacrifice. Planar X-ray of hind limbs and ex vivo fluorescence imaging of the whole body were performed at sacrifice. The observed tumor take rate was 100%. 33% of mice in the vehicle group were cachectic, but mice treated with SOC exhibited only mild and temporary weight loss. Tumors were observed mainly in skeletal sites but also in soft tissues. The SOC treatment decreased both total and skeletal tumor burden. Based on X-ray images, tumor induced osteolytic bone lesions were smaller in the SOC treated group compared to vehicle though no differences were observed in total bone lesion area. Serum TRACP5b was increased in the vehicle group as a result of osteolytic lesions, and decreased with the SOC treatment. In conclusion, an intracardiac model of MBC was successfully validated with the SOC treatment paclitaxel that efficiently inhibited disease progression. Therefore, this intracardiac model provides a promising tool for testing new treatments against bone and soft tissue MBC in vivo. Citation Format: Justyna Zdrojewska, Mari I. Suominen, Katja M. Fagerlund, Jussi M. Halleen, Jenni Bernoulli, Johann Zimmermann. Validation of a preclinical model for bone metastatic triple negative breast cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2007.
Pathologic fracture of the proximal femur
Authors: O. E. Aufranc
Journal: JAMA (1967)

Dr. Richard G. McCollum: An 18-year-old girl was admitted to a neighboring teaching hospital with a one-year history of pain in the lower left side of her back, left hip, and left thigh. She reported that this had been steadily progressive over the past 12 months. Two months prior to the current admission, her case had been evaluated in another hospital with a series of roentgenograms including a lumbar myelogram, all of which were normal. Results of physical examination on admission were normal except for the left leg. There was mild induration and increased warmth of the outer aspect of the left thigh just below the hip joint. The proximal left thigh measured 2 cm larger in diameter than the right and was slightly tender to palpation. Laboratory data were normal except for the following: hemoglobin value, 9.3 gm/100 cc; corrected sedimentation rate, 32 mm/hr. Roentgenograms were normal except for
Circulating concentration of cardiac troponin T is useful for risk stratification in patients with chronic hemodialysis: One-year outcome analysis in 394 hemodialyzed patients Junnichi Ishii, Takanobu Toriyama, Masanori Nomura, Hiroyuki Naruse, Yoshihisa Mori, Masaki Yokoya, Yoshitaka Kumada, Hiroshi Takahashi, Hirohisa Kawahara, Yoshihiko Watanabe, Hitoshi Hishida. Fujita Health University, Toyoake, Japan, Nagoya Kyoritsu Hospital, Nagoya, Japan
Journal: Journal of the American College of Cardiology (2001)
CRIMINAL ABORTION.
Authors: WILLIAM McCOLLOM
Journal: JAMA (1896)

I use the words in their legal sense, viz, the effecting of the unlawful expulsion of the contents of the womb at any time after conception before the term of gestation is complete. The very old English law made a distinction between the crime perpetrated before and after quickening. The rulings of the supreme court of several of the American States corresponded with the old English law which was abolished a half century, more or less, ago. The Pennsylvania court was one of the first to discard the old doctrine and the courts of many of the other States have progressively fallen into line, and have ruled that it is a crime to destroy embryo life after gestation has begun. Judge Coulter, of Pennsylvania, ruled that "it is not the murder of a living child which constitutes the offence, but the destruction of gestation." An attempt by a physician or
Viral Orchitis
Authors: Stuart Riggs, Jay P. Sanford
Journal: New England Journal of Medicine (1962)

ACUTE orchitis is an alarming and painful affliction. Its association with mumps was clearly described by Hippocrates1 more than four hundred years B.C.:[In an epidemic on the island of Thasus] Swellings appeared about the ears, in many on either side, and in the greatest number on both sides,... neither did any of them come to suppuration,... In some instances earlier, and in others later, inflammations with pain seized sometimes one of the testicles, and sometimes both....Through the years the association of mumps with orchitis has become widely recognized. However, in a thorough review of this subject by Roseman . . .
MISCELLANY.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Questions and Answers
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Line Transposed
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Some Problems of Hyperparathyroidism
Authors: C. E. Dent
Journal: BMJ (1962)

MEDiBARISH 1495 as effective observation units where the correct disposal would be worked out. SummaryThe course and outcome of patients aged 60 and over admitted to the geriatric unit and the mental hospital serving the city of Belfast have been examined.Comparisons were made between those correctly placed and those misplaced-that is, those whose principal illness was one which would have been more appro- priately treated in the other hospital.The misplaced patients had a higher mortality in hospital than was found among the correctly placed patients.This was so in both hospitals.Also, their mortality was higher than that of patients suffering from similar ailments who had been admitted to the proper unit.Among the survivors, the misplaced patients were less often discharged than correctly placed patients.These differences were not accounted for by differences in age or sex, or by the seriousness of the illnesses.Patients with mixed physical and mental disabilities did not have an especially bad prognosis.Misplacement itself seemed to be directly responsible for the poor outcome of the patients.Reasons for this poor outcome are discussed, and ways of avoiding misplacement are outlined.
Monoclonal IgM immunoglobulinemia in psoriatic arthritis
Authors: J. E. Lergier
Journal: JAMA (1975)

Serum protein electrophoresis in a 61-year-old woman with psoriasis and psoriatic arthritis showed a monoclonal spike that was identified as IgM-k monoclonal immunoglobulinemia by immunodiffusion and immunoelectrophoresis. There was no clinical evidence of myeloma, Waldenström macroglobulinemia, or lymphoma, and the M component has not changed over a three-year observation period. This unusual occurrence may represent another disease entity that may be associated with nonmyelomatous monoclonal immunoglobulinemia. (<i>JAMA</i>231:171-173, 1975)
Book Review Plastic Surgery of the Orbit . By J. Eastman Sheehan, M.D., F.A.C.S., Professor of Plastic Surgery, New York Post-Graduate Medical School and Hospital; Associate Surgeon and Lecturer to the International Clinic of Otorhinolaryngology and FacioMaxillary Surgery, Paris; Member of Royal Society of Medicine, London; Member, American Association of Oral and Plastic Surgeons.
Journal: New England Journal of Medicine (1928)
The Life of Jacob Henle.
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE RELATION OF HEREDITY TO CANCER
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
P68: Dupilumab provides improvement in sleep in children aged ≥ 6 years with severe atopic dermatitis (AD) and adolescents with moderate‐to‐severe AD
Authors: J Bernstein, M Maurer, A Gim Enez-Arnau, W Soong, G Sussman, M Metz, B Lanier, K Sitz, M Hide, E Hua, A Barve, T Severin, R Janocha
Journal: British Journal of Dermatology (2021)

Table 1 Disease activity in the core study (week 20) and extension study (week 52) Treatment group (all Q4W) Well-controlled (UAS7 ≤ 6), n (%) Median duration of well-controlled activity (weeks) Core study, week 20 Ligelizumab 72 mg (n = 78) 51 (65Á4) 8Á0 Ligelizumab 240 mg (n = 74) 38 (51Á4) 16Á0
Psychiatric Problems in Obese Children Followed up for 10 Years
Authors: Alan M. Schindler
Journal: JAMA (1991)

<h3>To the Editor.—</h3> The report by Epstein et al,<sup>1</sup>"Ten-Year Follow-up of Behavioral, Family-Based Treatment for Obese Children," notes long-term positive results with that mode of treatment applied to 76 selected patients: obese children with intact families, no history of psychiatric contact, at least one obese parent, and one parent willing to attend treatment meetings. Noted by the authors, but otherwise overlooked in the discussion of the outcome of this study, were the psychopathological effects that occurred among these 76 supposedly psychologically healthy children. Near the beginning of the study, one of the 76 children was dropped because of "unreported psychiatric problems." During the second 5 years, six of the 67 children who were still eligible for the study developed "significant psychiatric problems that required hospitalization and long-term medication use." Three children had manic-depressive illness, two had major depression with suicide attempts, and one developed an eating disorder. Finally,
Regulation of immunity by lysosphingolipids and their G protein–coupled receptors
Authors: Edward J. Goetzl, Hugh Rosen
Journal: Journal of Clinical Investigation (2004)

T and B lymphocytes, as well as endothelial cells, express distinctive profiles of G protein–coupled receptors for sphingosine 1–phosphate, which is a major regulator of T cell development, B and T cell recirculation, tissue homing patterns, and chemotactic responses to chemokines. The capacity of drugs that act on type 1 sphingosine 1–phosphate receptors to suppress organ graft rejection in humans and autoimmunity in animal models without apparent impairment of host defenses against infections suggests that this system is a promising target for new forms of immunotherapy.
'Wabi-Sabi'
Authors: Joshua D. Schor
Journal: JAMA (1984)

In 1983, having just finished my third year in medical school, I received a Henry R. Luce Fellowship to study geriatric medicine at a large hospital in Tokyo. During my year here, I have come to realize that the Japanese practice of medicine simulates much of what has been familiar to me in America. However, as a young, perhaps naive, observer, I have been struck most by one cultural difference between these two medical societies. And as an American wrestling with a very foreign way of everyday life, it is the only point of difference I feel well equipped to discuss. In Japan, an eye always seems cocked toward America, and medicine is no exception. Many physicians have asked me about what seems most on their minds as Japanese: the doctor-patient relationship. Specifically, I repeatedly have been asked whether American physicians really tell their patients the truth. In serious cases,
Education for health. A role for physicians and the efficacy of health education efforts. Council on Scientific Affairs
Journal: JAMA (1990)

Health education efforts have grown dramatically over the past decade and seek to improve the health of individuals by providing them with information that will lead to behavioral changes and thereby result in improved health. There is now substantial evidence to support the idea that health education activities can alter health behaviors, even though the mechanisms by which health education efforts succeed are largely unknown. Physicians could add to the success of health education efforts by incorporating preventive services into their patient encounters, particularly patients in high-risk situations. There are many examples of successful physician-based interventions, and a new emphasis on preventive services in primary care is emerging.