tbuckley/cabot-search huggingface dataset:
Phase II study of oral fluoropyrimidine anticancer agent (S-1) with concurrent external-beam radiotherapy for locally advanced pancreatic cancer
Authors: H. Shinchi, Y. Mataki, H. Kurahara, S. Maeda, H. Noma, K. Maemura, S. Takao
Journal: Journal of Clinical Oncology (2008)

15526 Background: S-1 is a new oral fluoropyrimidine anticancer agent and has shown a good efficacy for pancreatic cancer. In the phase I trial, we evaluated the safety of S-1 combined with external-beam radiotherapy (EBRT) to determine the maximum tolerated dose (MTD) and dose-limiting toxicity (DLT) in unresectable pancreatic cancer patients (ASCO 2006, Br J Ca 2007). This phase I trial determined the recommended of S-1 for the phase II chemoradiotherapy trial to be 80 mg/m2/day given on days 1–21. This phase II study was conducted to evaluate the efficacy and toxicity of EBRT combined with S-1 for locally advanced pancreatic cancer. Methods: Eligible patients had locally advanced and unresectable pancreatic cancer without distant metastases, ECOG PS 0–1, adequate organ and marrow function, and no prior anticancer therapy. S-1 was given orally at a dose of 80 mg/m2/day twice a day on days 1–21. EBRT was delivered in fractions of 1.25 Gy × 2 per day, totaling 50 Gy per 40 fractions for 4 weeks. After completion of chemoradiotherapy, S-1 was administered for 14 days followed by a 14-day rest period and continued until disease progression or unacceptable toxicity as maintenance. Results: A total of 26 patients have been enrolled to date in this phase II study. Median follow-up period is 10 months (4–27 months). Of the 26 patients, 25 (96%) completed the scheduled course of chemoradiotherapy. The objective tumor responses by RECIST criteria included 9 PR (35%), 13 SD (50%) and 4 PD (15%). Serum CA19–9 decreased > 50% in 11 of 19 evaluable patients (58%). Thus far the median survival time is 14 months and 1-year survival rate is 67%. Although grade 3 rash and anorexia occurred in one patient each, no grade 4 toxicities were observed. Conclusions: Combination therapy of S-1 and radiation in patients with locally advanced and unresectable pancreatic cancer appears to be a promising and well-tolerated approach with consideration of application to outpatients. No significant financial relationships to disclose.
Jade
Authors: Natalie A Mariano
Journal: Annals of Internal Medicine (2010)

On Being a Doctor6 July 2010JadeNatalie A. Mariano, MDNatalie A. Mariano, MDFrom Providence Veterans Affairs Primary Care Center, Hyannis, MA 02601.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-153-1-201007060-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail I've never seen her smile, but today her face was soft and childlike despite the wire rings piercing her eyebrows and lips. A stubble of blond hair poked out of her scalp, making her look like a kid with his first crewcut. She wore a white cotton tank top that clung tightly to her small breasts and baggy fatigues tucked into the tops of heavy army boots laced halfway up her thin calves. Fiery tattoos swirled up her arms, and images of thick black chains were emblazoned around her neck.“I'm applying for a scholarship to go back to school,” ... Author, Article, and Disclosure InformationAffiliations: From Providence Veterans Affairs Primary Care Center, Hyannis, MA 02601.Corresponding Author: Natalie A. Mariano, MD, Box 897, West Falmouth, MA 02574; e-mail, [email protected]com. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHarnwegsinfektionen bei geriatrischen PatientenÜber Meningopathia traumatica im Bereich der Cauda equina (sog. Arachnitis adhaesiva circumscripta) 6 July 2010Volume 153, Issue 1Page: 56KeywordsArthritisCardiovascular therapyHipLungsOverweightPainPatient advocacyScarsShouldersWalking ePublished: 6 July 2010 Issue Published: 6 July 2010 Copyright & PermissionsCopyright © 2010 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Self-Incompatibility System of Oenothera organensis for the Detection of Genetic Effects at Low Radiation Doses
Authors: K. Sree Ramulu, Hannelore Schibilla, P. Dijkhuis
Journal: Environmental Health Perspectives (1981)

The self-incompatibility system of Oenothera organensis is used to analyze the frequency of S locus mutations induced by low doses (2.5-20 rad) of fast neutrons and x-rays. Th principles and methods of the screening system for detection of low dose effects have been presented. The results show that low doses induced significantly higher frequencies of seeds and seedlings than those produced spontaneously. The analyses of part of the progenies derived from the control and treated series suggested that they were due to revertible mutations. A modified in vitro method of culturing pollinated cut styles has been developed for rapid screening of compatible pollen tubes.
Serological tests for kala-azar work well
Journal: BMJ (2006)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following Serological tests for kala-azar work well Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Effects of Nutritional Factors on Metabolism of Dietary Cadmium at Levels Similar to Those of Man
Authors: M. R. Spivey Fox, R. M. Jacobs, A. O. Lee Jones, Bert E. Fry
Journal: Environmental Health Perspectives (1979)

Several nutrients are known to affect cadmium toxicity, but little is known about the effect of dietary nutrient levels on absorption and tissue retention of cadmium at low dietary levels, similar to those of man. Feeding gradedlevels of zinc in a casein-gelatin diet to young Japanese quail with 109Cd (as the chloride) and 0.062 ppm added cadmium decreased the cadmium concentrations in the proventriculus-ventriculus, duodenum, jejunum-ileum, and the liver, but not in the kidney. Zinc also affected some zinc, iron, manganese, and copper tissue levels. Different tissue concentration patterns of cadmium and essential minerals were obtained with two purified control diets, one based on casein-gelatin and the other on soy isolate as the principal protein sources. The data show that relatively small dietary changes can markedly affect tissue levels of cadmium and that a low intake of zinc may increase the risk to dietary cadmium exposure. The complexity of the nutrient interrelationships and their effects on cadmium require further study to define mechanisms, which may be similar to those produced by low cadmium intakes in man.
Notes and news
Journal: Annals of the Rheumatic Diseases (1991)

It is encouraging to note that blind and disabled people who are unable to use 'phone books will not have to pay for calls to directory inquiries when British Telecom introduces a charge in 1991, but they will benefit nevertheless from new lower call charges being introduced at the same time.Under the new arrangements blind and disabled people will first have to register with British Telecom using a free linkline number 0800 919195.After certification by a health or community worker they will be issued with a card with large print or braille if necessary.A new three digit number will be set up linking calls to a special bureau in Sheffield specifically designed to answer their inquiries.They will then have to give their PIN number and name.As soon as their PIN has been validated they can ask for their two directory inquiry searches as at present.
Röntgenatlas der Lungenerkrankungen: Ein Leitfaden für Ärzte.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cross-talk between regulation of iron homeostasis and gluconeogenesis in a murine model of hereditary hemochromatosis
Authors: Elena Buzzetti, Cinzia Garuti, Chiara Vecchi, Giuliana Montosi, Mauela Sabelli, Paolo Ventura, Andrew Armitage, Elena Corradini, Alexander Drakesmith, Antonello Pietrangelo
Journal: Journal of Hepatology (2020)
Medicine's role evolves in Haiti restoration
Authors: P. Gunby
Journal: JAMA (1994)

PHYSICIANS HAVE been involved in Operation Uphold Democracy—the effort to restore President Jean-Bertrand Aristide to office—from the planning stage into this 12th week of US military presence in Haiti. James B. Peake, MD, who was involved in planning the operation and who flew into Port-au-Prince with the first US forces September 19, has returned to the United States, been promoted to the two-star grade of major general, and has taken command of Madigan Army Medical Center, Tacoma, Wash. US Army physicians in command in Haiti now are V. Thomas Deal, Jr, MD, commanding the 28th Combat Support Hospital in Port-au-Prince in the south on the Bay of Gonave not far from the Caribbean Sea, and Larry J. Godfrey, MD, working as the joint task force surgeon, with medical assets in Port-au-Prince as well as Cap Haitien on the north (Atlantic Ocean) coast, and with the 10th Mountain Division. Deal is
Ig Receptor Binding Protein 1 (α4) Is Associated With a Rapamycin-Sensitive Signal Transduction in Lymphocytes Through Direct Binding to the Catalytic Subunit of Protein Phosphatase 2A
Authors: Seiji Inui, Hideki Sanjo, Kazuhiko Maeda, Hideyuki Yamamoto, Eishichi Miyamoto, Nobuo Sakaguchi
Journal: Blood (1998)
‘The Blues'
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BUENOS AIRES
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ECMO/PPHN
Authors: V. L. Montgomery, S. M. Eberly, K. Mellgren, M. Skogby, L. G. Friberg, H. Wadenvik, G. Mellgren, S. Maglajlić, I. Jovanović, V. Parezanović, V. Vušurović, R. Koš, S. Laban-Nestorović, Iqbal Mustafa, Embing Sjamsubin, Marteye Martona, Spemato Heru Samudra, Yusuf Rachmat, Anna Ulfah Rahayoe, Zuswahyudha Samsu
Journal: Intensive Care Medicine (1996)
Silver Stools
Authors: Donald A. Passidomo
Journal: JAMA (1980)

<h3>To the Editor.—</h3> In reference to the letter by Michael C. Perry, MD (243:1809, 1980), concerning the article by Ong and Pintauro on "Silver Stools" (242:2433, 1979), I would like to attest to the fact that although this condition is scarce in the literature, it is certainly understandable why Ong and Pintauro did not use Sherlock and Summerfield's excellent book<i>Color Atlas of Liver Disease</i><sup>1</sup>in their bibliography. It was simply because the book just happened to be published at the same time this article was written and submitted for publication. By coincidence I was subject to a similar dilemma when attempting to respond to a surgeon's request for current information on this same topic several months ago. Although I conducted a computer search of the current literature in MEDLINE and related data bases and also scanned various textbooks, I was unable to retrieve any current information on this subject.
METABOLIC "WASTE HEAT"
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Syphilis in the elderly
Authors: E. A. Luke
Journal: JAMA (1985)

<h3>To the Editor.—</h3> I am writing in reference to the article, "The 'Terrible' Question," in which Dr Stanley Bierman<sup>1</sup>wrote about the difficulty of inquiring into the personal sexual history of an older person, and what we uncover when we do. Recently I had the occasion to assist in the care of a 92-year-old woman who was evaluated for severe dementia and was discovered to have a 4+ FTA-ABS result. Tertiary syphilis must always be considered in the evaluation of dementia. Although relatively rare today, this condition may not be so rare in the present elderly cohort, who may have contracted syphilis when much younger. This is not the first case of syphilis I have seen among elderly patients suffering from dementia. Dr Bierman's article stimulated our team to consider that we might be observing not tertiary syphilis, but rather a recent acute stage. We began to explore our
Erratum: Lineage specification of human dendritic cells is marked by IRF8 expression in hematopoietic stem cells and multipotent progenitors
Authors: Jaeyop Lee, Yu Jerry Zhou, Wenji Ma, Wanwei Zhang, Arafat Aljoufi, Thomas Luh, Kimberly Lucero, Deguang Liang, Matthew Thomsen, Govind Bhagat, Yufeng Shen, Kang Liu
Journal: Nature Immunology (2017)
The Lurking Sperm
Authors: Philip M. Alderman
Journal: JAMA (1988)

Vasectomy techniques and failure rates vary among surgeons, and the criteria for failure are not often clearly defined. To help establish a yardstick for comparative purposes, a series of 8879 consecutive vasectomies performed with uniform technique over 24 years was reviewed. A subgroup of 5331 men who had returned for at least two postoperative semen tests—the<i>study</i>group—was used for follow-up analysis. Failures were defined as<i>early</i>or<i>late</i>and also were categorized as overt or<i>technical</i>according to the numbers, motility, or persistence of the remaining spermatozoa. There were 97 failures of all types, including 32 (0.60%) early and overt failures and 61 (1.14%) technical failures that involved the persistence of small numbers of spermatozoa, possibly of no significance. Four (0.08%) late overt failures were also seen; each of these was discovered as a result of a pregnancy, and each occurred at least four years after two azoospermic test results. Of the 97 failures, four were recognized as due to missed vasa deferentia, and the remainder were attributed to recanalization. Whether improved and reproducible failure rates can be consistently obtained by other techniques is not yet clear. (<i>JAMA</i>1988;259:3142-3144)
189P Phase II trial of S-1 plus panitumumab for wild-type KRAS unresectable colorectal cancer patients previously treated with 5-fluorouracil (5-FU), oxaliplatin and irinotecan (KSCC1103)
Authors: Y. Sakamoto, Y. Yoshida, H. Ishikawa, T. Ohchi, H. Takeshita, Y. Emi, H. Komatsu, T. Sawai, T. Shimose, E. Oki, H. Saeki, Y. Kakeji, Y. Yoshida, H. Baba, Y. Maehara
Journal: Annals of Oncology (2016)
Follow-Up of Complete Cytogenetic Remission in Patients With Chronic Myeloid Leukemia After Cessation of Interferon Alfa
Authors: F. X. Mahon, X. Delbrel, P. Cony-Makhoul, C. Fabères, J. M. Boiron, C. Barthe, C. Bilhou-Nabéra, A. Pigneux, G. Marit, J. Reiffers
Journal: Journal of Clinical Oncology (2002)

A small proportion of patients with chronic myeloid leukemia (CML) achieve a complete cytogenetic response (CCR), defined as the disappearance of Philadelphia (Ph) chromosome-positive metaphases, after treatment with interferon alfa (IFN). In this population of patients, the question of whether treatment should then be withdrawn is not yet resolved.In the present study, we followed 15 patients who stopped IFN after achieving CCR. In nine patients IFN was stopped in view of adverse reactions (n = 8) or patient's choice (n = 1). For the remaining six patients, the treatment was stopped because no BCR/ABL rearrangement could be detected by reverse transcriptase polymerase chain reaction (RT-PCR) in four successive analyses using peripheral-blood samples.Loss of CCR and survival were not statistically different (P =.48; P =.7) for the 15 patients who stopped IFN compared with 41 other CCR patients who continued IFN therapy in our institution. The median follow-up after discontinuation of IFN treatment was 36 months (range, 6 to 108 months). Seven patients (47%) (females, or CCR > 24 months and RT-PCR negative before IFN cessation; P <.0001) did not relapse. Eight other patients (53%) relapsed (lost CCR) within 3 to 33 months of treatment discontinuation. One of them relapsed in major cytogenetic remission (MCR) and was still in MCR 87 months after stopping therapy without any treatment.It is possible to stop IFN treatment at least in some patients with CML who achieve a prolonged period of CCR. This study also illustrates the hypothesis that persistence of low numbers of Ph-positive cells does not necessarily imply hematologic relapse.
Medical problems of adults who were sexually abused in childhood.
Journal: BMJ (1990)

been developing such systems for the management of a varietv of medical conditions, of which a system for the diagnosis, physical examination, and treatment of hvpercholesterolaemia is cur- rentlv undergoing field trials with general practi- tioners in the west midlands.The system is supplied for the use of a Psion Organiser and incorporates regional knowledge in a particular subject as appropriate for use in primary care or by junior hospital medical staff.The medical know-
Anesthesia and Analgesia: Current Researches, Cleveland
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Transplantation Immunology
Authors: Anne M. VanBuskirk
Journal: JAMA (1997)

The practice of clinical and experimental transplantation continues to evolve at a rapid pace. To appreciate the current transplant practices, it is first necessary to review transplant immunology in its proper context, ie, as a component of the complex series of events that promote the repair of damaged tissues. These processes are generally catagorized as inflammation, immunity, and tissue repair/reinforcement. In general, there are 3 forms of graft rejection: hyperacute, acute, and chronic rejection. All 3 forms of graft rejection represent pathologic consequences of one or more of these repair-related processes. The various graft rejection responses also illustrate several complex immunologic principles that need to be considered. These include the definition of an alloantigen, the structure and function of major histocompatibility complex molecules, and the behavior of antigen-presenting cells and alloreactive T cells. This review combines these concepts and principles into a discussion of the 3 forms of graft rejection, each of which is addressed at the level of histopathology, pathobiology, incidence, and clinical strategies.