tbuckley/cabot-search huggingface dataset:
Book reviews
Journal: Allergy (1989)

Books reviewed in this article: Veldman, J. E. &amp; McCabe, B. F. (eds.): Oto‐immunology. Goldman, J. L. (ed.): The principles and practice of rhinology. Flint, K. C : Bronchoalveolar mast cells and asthma. In: Tinker, J. (ed.): Bloomsbury Series in Clinical Science. Plaut, T. F. : Children with asthma. Bierman, C. W. &amp; Pearlman, D. S. : Allergic diseases from infancy to adulthood. Armour, C. L. &amp; Black, J. L. (eds.): Progress in clinical and biological research. Volume 263: Mechanisms in asthma.
Manuscripts Approved for JNCI, October 1 to November 1, 1966
Journal: JNCI Journal of the National Cancer Institute (1966)

Manuscripts Approved for JNCI, October 1 to November 1, 1966 Get access JNCI: Journal of the National Cancer Institute, Volume 37, Issue 6, December 1966, Page 908, https://doi.org/10.1093/jnci/37.6.908 Published: 01 December 1966
Headaches and coffee.
Journal: BMJ (1977)

easier if greater attention was paid to the basic epidemiological rules of precise description of what is being studied or observed and careful definition of the populations covered by the observations.The difficulties could be reduced still further if specialists, generalists, and epidemiologists more often discussed the design of research before it took place rather than lamenting missed opportunities afterwards.And how much easier it would be for the clinician looking for guidance.
THE SCIENTIFIC DEPARTMENTS OF OUR DRUG MANUFACTORIES.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PWE-008 Do statins prevent the histological subtypes of oesophageal cancer? Prospective data from the UK general practice research database (GPRD)
Authors: H Y Bhutta, L Alexandre, A Clark, S Holt, M Lewis, A Hart
Journal: Gut (2012)

<h3>Introduction</h3> The incidence of oesophageal adenocarcinoma (OAC) has risen dramatically in the Western world and is associated with a poor prognosis. Statins show anti-cancer properties in experimental work with OAC cell lines for example reduced cell proliferation, increased apoptosis. This study aimed to investigate if statins are negatively associated with the development of two different histological subtypes of oesophageal cancer, OAC and oesophageal squamous cell cancer (OSCC), in a prospective cohort study. <h3>Methods</h3> The cohort was over 4 million people in the General Practice Research Database (GPRD), a UK database of 488 nationwide general practices. Information is recorded on medication use prior to development of other illnesses, including cancers. Statin use was defined as a prescription for a minimum of 10 months preceding diagnosis of oesophageal cancer. Approximately half the GP practices in the GPRD are linked to the NHS cancer registry, allowing identification and sub-classification of histologically confirmed cases of OAC and OSCC. Each case was matched with four controls and conditional logistic regression estimated the OR plus 95% CIs for the development of each type of cancer, adjusted for diabetes, BMI, smoking, aspirin, PPIs and drugs that relax the lower oesophageal sphincter. <h3>Results</h3> 581 histologically confirmed cases of OAC (77.8% men, mean age 70.7 years, SD=11.4) and 332 cases of OSCC (38.6% men, 71.9 years, SD=12.3) were identified between 2000 and 2008. The median length of statin use in cases and controls prior to diagnosis or index date was 3.9 years (IQR 2.3–6.1 years). Analysis by histological subtype showed an inverse association for OAC (OR 0.61, 95% CI 0.39 to 0.94) and for OSCC (OR 0.41, 95% CI 0.21 to 0.80). Categorisation into lipophilic and hydrophilic statins demonstrated significant inverse associations for only lipophilic statins for both OAC (OR 0.60, 95% CI 0.38 to 0.95) and OSCC (OR 0.46, 95% CI 0.23 to 0.91). There was a dose-response effect for statins and both OAC and OSCC (p&lt;0.05 for linear trend) comparing high and low-dose statin use. <h3>Conclusion</h3> The data supports lipophilic statins having a protective effect against the development of both OAC and OSCC, with evidence of a dose-response trend. Confirmation in other populations is required. Detailed statin use, according to class and dose, should be measured in future aetiological studies of both OAC and OSCC. The information supports assessment of these drugs in chemoprevention of OAC in the general population and those with Barrett9s oesophagus in clinical trials. <h3>Competing interests</h3> None declared.
Dr. Hippolyte Bernheim
Journal: BMJ (1919)

and Amasterda'm.A distinction which lie especially prized was the Fellowship of our Royal Society.His researchl work dealt mainly with tlle Ii rt, the cerebral cortex, the cerebellum, and the plhysiology of fasting.His treatise on human physiology, now in its fifth edition, lhas been translated into Englisl, German, and Spanish.
A Text-Book of Practical Therapeutics: With Especial Reference to the Application of Remedial Measures to Disease and Their Employment On a Rational Basis.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Temporal Arteritis
Authors: G. H. Jennings
Journal: BMJ (1966)

<h3>Abstract</h3> <h3>Background</h3> Coronavirus disease 2019 (COVID-19) has been especially dangerous for elderly people. To reduce the risk of transmission from healthcare workers to elderly people, it is of utmost importance to detect possible severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positive healthcare workers as early as possible. We aimed to determine whether the Abbott Panbio™ COVID-19 antigen detection rapid diagnostic test (Ag-RDT) could be used as an alternative to reverse transcription-quantitative polymerase chain reaction (RT-qPCR). The second aim was to compare the cycle threshold (Ct) in RT-qPCR with the results of the Ag-RDT. <h3>Methods</h3> A prospective diagnostic evaluation of the Abbott Panbio™ COVID-19 Ag-RDT among healthcare workers across three elderly care facilities as well as home-based elderly care workers who met clinical criteria for COVID-19 during the second wave of the COVID-19 pandemic. Per healthcare worker, the first nasopharyngeal swab was obtained to perform the Ag-RDT and the second swab for RT-qPCR. A Ct-value of &lt; 40 was interpreted as positive, ≥ 40 as negative. <h3>Results</h3> A total of 683 healthcare workers with COVID-19 symptoms were sampled for detection of SARS-CoV-2 by both Ag-RDT and RT-qPCR. Sixty-three healthcare workers (9.2%) tested positive for SARS-CoV-2 by RT-qPCR. The overall sensitivity of Ag-RDT was 81.0% sensitivity (95%CI: 69.6-88.8%) and 100% specificity (95%CI: 99.4-100%). Using a cut-off Ct-value of 32, the sensitivity increased to 92.7% (95% CI: 82.7-97.1%). Negative Ag-RDT results were moderately associated with higher Ct-values (<i>r</i> = 0.62) compared to positive Ag-RDT results. <h3>Conclusion</h3> The Panbio™ COVID-19 Ag-RDT can be used to quickly detect positive SARS-CoV-2 healthcare workers. Negative Ag-RDT should be confirmed by RT-qPCR. In case of severe understaffing and with careful consideration, fully vaccinated healthcare workers with Ag-RDT negative results could work with a mask pending PCR results.
PUBLIC HEALTH.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diagnostic and therapeutic technology assessment. Endoscopic balloon dilation of the prostate
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
DO THE DIFFERENT IMMUNOLOGIC REACTIONS DEPEND ON ONE OR SEVERAL ANTIBODIES?
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 2629: Constitutive AhR signaling enhances androgen receptor signaling and growth in prostate cancer cells
Authors: Maryam Ghotbaddini, Sakura McLaughlin, Kailen Turner, Devyn Pirtle, Joann B. Powell
Journal: Cancer Research (2019)

Abstract The aryl hydrocarbon receptor (AhR) has been reported to interact with multiple signaling pathways during prostate cancer progression to castration resistant prostate cancer (CRPC) including the androgen receptor. Previously published data from our lab shows that AhR protein is overexpressed and constitutively active in castration resistant (DU145, PC3 and PC3M) prostate cancer cells. Pharmacological inhibition of AhR in these advanced prostate cancer cell lines reduced the growth rate under androgen depleted conditions. Furthermore, shRNA mediated depletion of AhR expression in castration resistant C4-2 cells, which were derived from hormone sensitive LNCaP cells, resulted in decreased expression of androgen responsive genes as well as a decreased growth rate which was comparable to LNCaP cell growth. In the present study, we evaluate cloneA (moderate increase in AhR) and CloneB (high increase in AhR) for alterations in AhR and AR signaling. AhR was overexpressed in LNCaP using PLNCX2 retrovirus vector containing AhR cDNA to determine if ectopic overexpression alone induces a castrate resistant phenotype. The highly overexpressed AhR clone (CloneB) illustrated further increase in transcriptional and promotor activity for AhR and AR compared to the moderately overexpressed AhR clone (Clone A) and control. Western blot analysis showed more AhR, AR, cSrc, and pSrc protein expression in clones compared to empty vector control. AhR overexpression was found to induce several biological properties such as migration, invasion, proliferation, and promotion of G1 to S phase during the cell cycle. Bicalutamide treatment had no effect on AR transcriptional activity in either clone, proving resistance to anti-androgen therapy. Our results confirm that overexpression of AhR induces constitutive AhR activity and stimulates androgen receptor signaling. This suggests a role for AhR in the development of CRPC. Citation Format: Maryam Ghotbaddini, Sakura McLaughlin, Kailen Turner, Devyn Pirtle, Joann B. Powell. Constitutive AhR signaling enhances androgen receptor signaling and growth in prostate cancer cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2629.
Proc Soc Exper Biology &amp;amp; Medicine, New York
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Book Review A Research Conference on the Cause and Prevention of Dental Caries . Chicago, Illinois. July 1 and 2, 1938. Sponsored by The Good Teeth Council for Children, Incorporated. 8°, cloth, 178 pp., with 11 figures, 12 tables, 6 charts and 6 graphs. Chicago: Good Teeth Council for Children, Incorporated, 1940. $2.00.
Journal: New England Journal of Medicine (1942)
Changes in practice bring cardiologists conflicts
Authors: D. F. Phillips
Journal: JAMA (1996)

THE EXPONENTIAL growth of medical information, coupled with efforts to establish a system of evidence-based medicine, will create inevitable conflicts as cardiologists adapt to new demands under health care system reform, predicted Thomas Killip, MD, chief of cardiology at Beth Israel Medical Center, New York, NY, at the opening plenary session of the American College of Cardiology meeting. His presentation, "Evidence-Based Practice and Health Care Reform," was this year's Simon Dick Lecture. "Evidence-based medicine" is defined as the use of scientific data to confirm that proposed diagnostic or treatment procedures are appropriate in light of their high probability of producing the best and most favorable outcome. As a recent article in<i>Science</i>(1996;272:22-24) put it, "all too often physicians rely on custom, hearsay, and dogma in choosing treatments." A new British journal,<i>Evidence Based Medicine</i>, the American College of Physicians'<i>Journal Club</i>, and other programs, said the article, "aim to
The Clinical Professor-Reply
Journal: JAMA (1983)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pathways of intracellular trafficking and release of ferritin by the liver in vivo: The effect of chloroquine and cytochalasin D
Authors: G Ramm
Journal: Hepatology (1994)

We have previously shown that the clearance of exogenous ferritin and the release of endogenous ferritin into both serum and bile are altered by the microtubular inhibitor colchicine. In this study we further examined the role of the lysosome-endosome pathway in ferritin metabolism. We examined the effect of the lysosomotropic agent chloroquine and the microtubular inhibitor cytochalasin D on the uptake and release of ferritin by normal and iron-loaded rats under basal conditions and in the presence of an exogenous tissue ferritin load. Either chloroquine (50 mg/kg body wt) or cytochalasin D (0.9 μg/100 gm body wt/min) was administered to normal and iron-loaded rats at zero time. Rats were also infused with either saline solution or rat liver ferritin containing a trace amount of 125I-ferritin. The clearance of 125I-ferritin from the circulation was not affected by chloroquine or cytochalasin D either in normal or in iron-loaded rats; however, both chloroquine and cytochalasin D decreased the serum ferritin concentration in normal rats to 39 ± 9 and 22 ± 7 of the baseline serum ferritin levels, respectively, implying that both drugs inhibited the release of endogenous ferritin in normal rats. In iron-loaded rats both chloroquine and cytochalasin D decreased the biliary ferritin concentration to 11 ± 1 and 37 ± 4 of the baseline ferritin levels, respectively, and the 125I protein-bound counts per minute in the bile to 50 of the control result. This finding is consistent with an inhibitory effect of both drugs on the biliary excretion of endogenous ferritin and the intracellular transport of exogenous ferritin, respectively. In the presence of an exogenous tissue ferritin load, there was no detectable inhibitory effect of either drug on the biliary excretion of either endogenous or exogenous ferritin. These results provide the following evidence: (a) the receptor-mediated endocytosis of ferritin is not dependent on functioning lysosomes or microfilaments; (b) the release of endogenous ferritin into the serum of normal rats and the bile of iron-loaded rats is a chloroquine-sensitive, microfilament-dependent process; (c) the biliary excretion of trace amounts of exogenous ferritin is dependent on both chloroquine-sensitive vesicles and microfilaments; and (d) increased levels of exogenous ferritin are excreted directly into the bile by way of a second microfilament-independent, chloroquine-insensitive pathway. This study provides support for a physiological mechanism for the release of ferritin from the liver. (Hepatology 1994;19:504–513).
Insanitary Houses in St. Pancras: A Correction
Journal: BMJ (1899)

xL Fo 89I M Querf, au,r, and communf.coatereuang to eBljCte to wuvk epeotw departments of the BmTs MmxcA JouwsAL are devoted wt be fousd uwder hr rapective headings.Qlo L. asks for information as to the causes of obstruction of the thoracic duct.J. S. writes: Have statistics been made recently of the proportion of cases of gonorrhcea which are attended or followed by epididymitis, or its relation to the locality where infection was obtained ?STATiM will be grateful for information as to the best books on (I) the duties of house-surgeons, ships' surgeons, etc.;(2) German-English, French-English phrase books for men practising amongst foreigners, and who desire to give them accurate and fairly lull medical directions without interpreters.These should be small for the pocket.PHYSICIAN would be obliged if any member would say if he knows of a home In England or Scotland where a woman, aged 50, with chronic bronchial asthma and debility could go.She could help with her room and do a little housework between her attacks.She is a widow without family and was lodgekeeper in the service of a peer for a number of years.Could pay probably 58. a week.