SUBTHRESHOLD DIABETES
Authors: J POMERANZE
Journal: Annals of Internal Medicine (1959)

Article1 August 1959SUBTHRESHOLD DIABETESJULIUS POMERANZE, M.D.JULIUS POMERANZE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-51-2-219 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA chronic disease process always exists in a preclinical state, in which its symptomatology is absent or vague, and its biochemical and metabolic changes are minimal and nonspecific. At such time, diagnostic reliance cannot be placed upon those obvious biochemical changes or gross clinical findings which are clearly evident only in the overt phase of the disease. We must therefore distinguish between the presence of a disease process and the recognition of its obvious diagnostic features. Our concept of the natural history of chronic diseases must be broadened and our diagnostic acumen sharpened. Early recognition and treatment will most favorably...Bibliography1. Dolger H: Clinical evaluation of vascular damage in diabetes mellitus, J. A. M. A. 134: 1289, 1947. CrossrefMedlineGoogle Scholar2. JoslinRootWhiteMarble EPHFPA: The treatment of diabetes, 8th Ed., 1946, Lea and Febiger, Philadelphia. Google Scholar3. ThompsonLaaksoWatson MWLEEM: Studies of the inheritance of diabetes mellitus. 1. The relation of heredity and the age of onset of diabetes, Canad. M. A. J. 63: 556, 1950. MedlineGoogle Scholar4. Steinberg AG: Heredity and diabetes, Eugenics Quart. 2: 26 (Mar.) 1955. CrossrefGoogle Scholar5. BowcockGreene HMEH: Observations in a case of renal glycosuria, during and after pregnancy, J. A. M. A. 90: 502, 1928. CrossrefGoogle Scholar6. Skipper E: Diabetes mellitus and pregnancy, Quart. J. Med. 2: 353, 1933. Google Scholar7. White P: Pregnancy complicating diabetes, Surg., Gynec. and Obst. 61: 324, 1935. Google Scholar8. MillerHurwitzKuder HCDK: Fetal and neonatal mortality in pregnancies complicated by diabetes mellitus, J. A. M. A. 124: 271, 1944. CrossrefGoogle Scholar9. PomeranzeStoneKing JMLEJ: The obstetric importance of obesity and benign glycosuria in prediagnosis diabetes, Obst. and Gynec., in press. Google Scholar10. NewburghConn LHJW: A new interpretation of hyperglycemia in obese middle-aged persons, J. A. M. A. 112: 71, 1939. Google Scholar11. Pomeranze J: Recurrent obesity, New York State J. Med. 56: 3017, 1956. MedlineGoogle Scholar12. SeltzerFajansConn HSSSJW: Spontaneous hypoglycemia as an early manifestation of diabetes mellitus, Diabetes 5: 437, 1956. CrossrefMedlineGoogle Scholar13. FajansConn SSJW: Further studies and tests for the "predetection" of diabetes mellitus, Clin. Res. Proc. 3: 120, 1956. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication January 21, 1959.From the New York Medical College, Metropolitan Medical Center.Requests for reprints should be addressed to Julius Pomeranze, M.D., 2 Fifth Avenue, New York 11, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byLiteraturverzeichnisDiabetes Mellitus in Advanced AgeDie diabetische NeuropathieDiabetic neuropathy ? Clinical and electrophysiological study in synalbumin positive and synalbumin negative subjectsÜber den Einfluß zusätzlicher Noxen auf Neuritis und Polyneuritis bei latentem Diabetes mellitus 1 August 1959Volume 51, Issue 2Page: 219-226KeywordsHypoglycemicsMetabolic disordersNatural history of diseaseNutrition ePublished: 1 December 2008 Issue Published: 1 August 1959 PDF downloadLoading ...