tbuckley/cabot-search huggingface dataset:
The CAIRO4 study: The role of surgery of the primary tumour with few or absent symptoms in patients with synchronous unresectable metastases of colorectal cancer—A randomized phase III study of the Dutch Colorectal Cancer Group (DCCG).
Authors: Jorine 't Lam - Boer, Linda Mol, Cornelis Verhoef, Mette K. N. Yilmaz, Ton de Haan, Cornelis J. A. Punt, Johannes H.W. de Wilt, Miriam Koopman
Journal: Journal of Clinical Oncology (2015)

TPS3630 Background: There is no consensus regarding resection of the primary tumour with few or absent symptoms in patients with synchronous unresectable metastatic colorectal cancer. A potential benefit of resection of the primary tumour is to prevent complications of the primary tumour in later stages of the disease. Retrospective studies also show a potential survival benefit for patients undergoing resection. However, surgery can cause severe morbidity and mortality in this patient group. We hereby propose a randomized trial in order to demonstrate that resection of the primary tumour improves overall survival. Methods: The CAIRO4 study is a multicentre, randomized, phase III study of the Dutch Colorectal Cancer Group (DCCG). Patients with synchronous unresectable metastases of colorectal cancer and few or absent symptoms of the primary tumour are randomized 1:1 between systemic therapy only, and resection of the primary tumour followed by systemic therapy. Patients will be stratified according to location of the primary tumour (colon versus rectum), WHO performance status (0-1 versus 2), hospital of inclusion, serum LDH (normal versus abnormal) and number of metastatic sites (single versus multiple). To demonstrate a survival benefit of 6 months in the experimental arm, a total of 218 events are needed (80% power, significance lever 0.05). Accounting for accrual time and follow-up, we need a total of 360 patients (180 patients per arm). Systemic therapy will consist of fluoropyrimidine-based chemotherapy in combination with bevacizumab. The primary objective of this study is to determine the clinical benefit in terms of overall survival of initial resection of the primary tumour. Secondary endpoints include progression free survival, surgical morbidity, quality of life and the number of patients requiring resection of the primary tumour in the control arm. Accrual has started in September 2012. As of January 2015, 64 centres in the Netherlands and Denmark are participating in the CAIRO4 study. Clinical trial information: NCT01606098.
Generation of Epstein Barr Virus Specific Cytotoxic T Lymphocytes (EBVCTLs) Resistant to the Immunosuppressive Drug Tacrolimus (FK506)
Authors: Biagio De Angelis, Gianpietro Dotti, Concetta Quintarelli, Leslie E Huye, Lan Zhang, Ming Zhang, Helen E. Heslop, Malcolm K Brenner, Cliona M Rooney, Barbara Savoldo
Journal: Blood (2008)
Upper extremity venous thrombosis with pulmonary embolism. A complication of excretory urography
Authors: G. P. Clagett
Journal: JAMA (1974)

A patient with a hypercoagulable state developed axillary-subclavian vein thrombosis with pulmonary embolism following excretory urography. Venous stasis, thrombocytosis, and endothelial injury from intravenous contrast media are incriminated in the pathogenesis of this complication. The effect of iothalamate sodium and diatrizoate meglumine-sodium (Renografin 76), on platelet aggregation was investigated and found not to induce platelet aggregation. Heparin sodium therapy should be considered prior to intravenous injection of contrast media in patients who have thrombocytosis.
Cutaneous Loxoscelism
Authors: Ilaria Trave, Gianfranco Barabino, Aurora Parodi
Journal: JAMA Dermatology (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
The Role of Cell Calcium in Current Approaches to Toxicology
Authors: Joel G. Pounds
Journal: Environmental Health Perspectives (1990)

All cells contain elaborate systems for the spatial and temporal regulation of the calcium ion, [Ca2+]i, and diverse Ca2+ receptor and biochemical response systems that are regulated by these changes in [Ca2+]i. Toxicants that perturb the mobilization or homeostasis of [Ca2+]i will place the regulation of these processes outside the normal range of physiological control. Many classes of chemical toxicants, including metals, solvents, and pesticides, may have particular aspects of cell calcium as key cellular and molecular targets of toxicant action. However, experimental proof of these targets as a specific site of toxicant action is challenging and technically difficult as a result of the complexity and diversity of these processes. To fully establish and understand the target role of the calcium messenger system in toxicant action, it is necessary to distinguish between the effects of a toxicant on (a) the calcium mobilization and homeostatic processes, (b) the calcium-mediated processes, and (c) from those processes which co-regulate or counter-regulate these calcium-mediated processes. As our understanding of the calcium messenger system expands, these insights will be increasingly applied to understanding the mechanisms of action of toxic chemicals.
CATHETERIZATION OF EUSTACHIAN TUBES THROUGH THE MOUTH
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AMA Insights
Journal: JAMA (1979)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Is Cocaine Desire Reduced by &lt;char aid="99897189" id="ital"&gt;N&lt;/char&gt;-Acetylcysteine?
Authors: Steven LaRowe
Journal: American Journal of Psychiatry (2007)

Objective: Animal models suggest that N -acetylcysteine inhibits cocaine-seeking. The present pilot study evaluated whether N -acetylcysteine would suppress reactivity to cocaine-related cues in cocaine-dependent humans. Method: In this double-blind, placebo-controlled trial, 15 participants received N -acetylcysteine or placebo during a 3-day hospitalization. Participants were crossed over to receive the opposite condition on a second, identical 3-day stay occurring 4 days later. During each hospital stay, participants completed a cue-reactivity procedure that involved collecting psychophysical and subjective data in response to slides depicting cocaine and cocaine use. Results: While taking N -acetylcysteine, participants reported less desire to use and less interest in response to cocaine slides and watched cocaine slides for less time. Conclusions: The inhibition of cocaine cue reactivity is consistent with existing preclinical data and supports the use of N -acetylcysteine as a treatment for cocaine dependence.
Mentally abnormal prisoners on remand.
Journal: BMJ (1988)

in response to hormone deficiency and replace- ment.This is shown by our longitudinal data and those of others.3The menopause is the most important factor in determining bone loss at the femoral neck.4Like Dr Selby and colleagues we do not know whether minor effects seen in cortical bone in the forearm or metacarpal have any relevance to the femoral neck.Their misquotation of a study of osteoporotic women in which no significant effect of calcium on cortical area was found does not add weight to their argument.Nor does Dr Gillespie's misinterpreta- tion of our table II, where negative percentage change values represent bone loss.There are certain times during life when extra calcium intake is required physiologically.These include growth, pregnancy, and lactation; but not the postmenopause.
Mumps Vaccine
Journal: Annals of Internal Medicine (1983)

Diagnosis and Treatment1 February 1983Mumps VaccineRecommendation of the Immunization Practices Advisory CommitteeAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-98-2-192 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail AbstractThis revised Immunization Practices Advisory Committee recommendation on mumps vaccine represents an updating of the 1980 recommendation. Changes include an expanded statement on allergic reactions. There are no major changes in approach.Selected Bibliography1. DRASH A. The etiology of diabetes mellitus [Editorial]. N Engl J Med. 1979;300:1211-3. CrossrefMedlineGoogle Scholar2. ENNISHOPPSDOUGLASMEYER FHRH. Hydrocephalus in hamsters: induction by natural and attenuated mumps viruses. J Infect Dis. 1969;119:75-9. CrossrefMedlineGoogle Scholar3. HARRISTURNBULLISACSONKARZONWINKELSTEIN RCPDW. Mumps in a northeast metropolitan community: I. Epidemiology of clinical mumps. Am J Epidemiol. 1968;88:224-33. CrossrefMedlineGoogle Scholar4. HAYDENPREBLUDORENSTEINCONRAD GSWJ. Current status of mumps and mumps vaccine in the United States. Pediatrics. 1978;62:965-9. MedlineGoogle Scholar5. HILLEMANBUYNAKWEIBELSTOKES MERJ. Live, attenuated mumps-virus vaccine. N Engl J Med. 1968;278:227-32. CrossrefMedlineGoogle Scholar6. KOPLANPREBLUD JS. A benefit-cost analysis of mumps vaccine. Am J Dis Child. 1982;136:362-4. MedlineGoogle Scholar7. SINANIOTISDASKALOPOULOULAPATSANISDOXIADIS CEPS. Diabetes mellitus after mumps vaccination [Letter]. Arch Dis Child. 1975;50:749-50. CrossrefMedlineGoogle Scholar8. WEIBELBUYNAKMCLEANHILLERMAN REAM. Followup surveillance of antibody in human subjects following live attenuated measles, mumps, and rubella virus vaccines. Proc Soc Exp Biol Med. 1979;162:328-32. CrossrefMedlineGoogle Scholar9. WITTEKARCHMER JA. Surveillance of mumps in the United States as background for use of vaccine. Public Health Rep. 1968;83:95-100. CrossrefGoogle Scholar10. YAMAUCHIWILSONST. GEME TCJ. Transmission of live, attenuated mumps virus to the human placenta. N Engl J Med. 1974;290:710-2. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: ▸From the Immunization Practices Advisory Committee, Centers for Disease Control; Atlanta, Georgia. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byFulminant Mumps MyocarditisSibat Chaudary, MD, Brian E. Jaski, MD 1 February 1983Volume 98, Issue 2Page: 192-194KeywordsAllergy and immunologyMumpsVaccines ePublished: 1 December 2008 Issue Published: 1 February 1983 PDF downloadLoading ...
Irreversible Pulmonary Changes Induced in Rat Lung by Dust Overload
Authors: Bernd Bellmann, Hartwig Muhle, Otto Creutzenberg, Robert Mermelstein
Journal: Environmental Health Perspectives (1992)

The objective of this study was to investigate whether the effects of dust overload are reversible upon cessation of subchronic exposure to test toner. Female rats were exposed 6 hr/day, 5 days/week for 3 months to a test toner at 0, 10, and 40 mg/m3. The retained quantity of test toner in the lungs at the end of exposure was 0.4 and 3.0 mg for the low and high exposure groups, respectively. Fifteen months later, the corresponding values were 0.12 and 2.65 mg in the lungs. Alveolar clearance of tracer aerosols as well as cytologic and enzymatic parameters in the bronchoalveolar fluid was investigated at the end of exposure and subsequently up to 15 months later. The alveolar clearance of 59Fe2O3, 51Cr-polystyrene, and 85Sr-polystyrene tracer aerosols was slightly retarded at the low and substantially impaired at the high exposure level. At the low exposure level, there was some recovery in the clearance behavior up to 6 months after exposure. In contrast, at the high exposure level there was no indication of a reversal of the impaired clearance. For the beta-glucuronidase activity and the number of polymorphonuclear cells, the pattern of the effects was similar to the effects on the half-time tracer particle clearance. In conclusion, the dust overload at a lung burden of 3 mg test toner in rats was persistent for at least 15 months after termination of exposure.
Medical History
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Watchful waiting vs immediate transurethral resection for symptomatic prostatism. The importance of patients' preferences
Authors: M. J. Barry
Journal: JAMA (1988)

The rate of resection for benign prostatic hypertrophy shows considerable variability among small geographic areas. To help inform the decision to recommend prostatectomy to men with prostatism without signs of chronic retention, we performed a decision analysis to compare the expected outcomes with immediate transurethral resection and watchful waiting. Data used in the model originated from the medical literature, Medicare claims data, and patient interview studies. In our base-case analysis for 70-year-old men, immediate surgery resulted in the loss of 1.01 months of life expectancy, but when adjustments were made for quality of life, immediate surgery was favored with a net utility benefit of 2.94 quality-adjusted life-months. However, the analysis was particularly sensitive to the degree of disutility attributed to the index symptoms of prostatism. We conclude that patient preferences should be the dominant factor in the decision whether to recommend prostatectomy. (<i>JAMA</i>1988;259:3010-3017)
IOWA MEDICAL LAW AND OSTEOPATHY.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Erratum: High resolution DNA Fiber–fish on yeast artificial chromosomes: direct visualization of DNA replication
Authors: Carla Rosenberg', Ralph Florijn', Frans Van De Rijke, Lau Blonden', Tonk Raap, Gert-Jan Van Ommen', M Kamboh', Dharambir Sanghera, Robert Ferrell', Steven Dekosky'
Journal: Nature Genetics (1995)
THE PATHOLOGY OF CONVULSIVE DISORDERS.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Handshake
Authors: Jason David Eubanks
Journal: Annals of Internal Medicine (2009)

Ad Libitum5 May 2009The HandshakeJason David Eubanks, MDJason David Eubanks, MDFrom the University of Pittsburgh Medical Center, Pittsburgh, PA 15213.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-150-9-200905050-00013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Deep in ... Author, Article, and Disclosure InformationAffiliations: From the University of Pittsburgh Medical Center, Pittsburgh, PA 15213.Current Author Address: Jason David Eubanks, MD, University of Pittsburgh Medical Center, 3471 Fifth Avenue, Pittsburgh, PA 15213. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 5 May 2009Volume 150, Issue 9Page: 646KeywordsEsophagusPelvisSleepSmell ePublished: 5 May 2009 Issue Published: 5 May 2009 Copyright & PermissionsCopyright © 2009 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Popular marathons, half marathons, and other long distance runs: recommendations for medical support: Recommendations of a consensus conference
Authors: Dan Pedoe, R Brotherwood, P Carson, Mr Collins, Maryon Davis, Andy Mr, John Mr, Ralph Mr, R Green, Mrs Macdonald, London Marathon, R Maughan, J Morris, Mr Sainsbury, Craig Sharp
Journal: British Journal of Sports Medicine (1984)

With the boom in jogging, the character of marathon and other long distance races has changed dramatically.A few years ago there were a few races for experienced club athletes who had usually had many years of athletics behind them and did not expect much in the way of facilities let alone medical support.In the past few years the number of races has increased almost logarithmically, reaching a total in 1983 in Great Britain of 136 full marathons (26 miles 385 yards, 42-2 km) with an average field of 1000 runners, but with fields as high as 20 000 in the London Marathon and even more for the Great North Run (half marathon).This boom in events has been associated with a change in the participants.They are now very largely novice runners unaffihiated to clubs, many of them (often as many as half)
Antibacterial Chemotherapy
Authors: Avram Goldstein
Journal: New England Journal of Medicine (1949)

Binding to Plasma Protein The experiments of Davis307 308 309 310 and subsequent reports by the same author and others311 , 312 established that sulfonamide action depends upon the level of unbound drug in the plasma water. At therapeutic concentrations sulfanilamide is protein bound to an extent of 20 per cent, sulfapyridine 40 per cent, sulfathiazole 75 per cent, sulfadiazine 56 per cent, sulfamerazine 84 per cent, and sulfamethazine 84 per cent.289, 308 , 313 , 314 It should be noted, however, that the usual technics for determining plasma levels do not distinguish between bound and unbound drug. The accepted bacteriostatic thresholds for various organisms also refer to total (bound . . .