tbuckley/cabot-search huggingface dataset:
CARDIAC SYMPTOMS
Authors: J PARKINSON
Journal: Annals of Internal Medicine (1951)

Article1 September 1951CARDIAC SYMPTOMSJOHN PARKINSON, M.D., F.R.C.P., F.A.C.P. (honorary)JOHN PARKINSON, M.D., F.R.C.P., F.A.C.P. (honorary)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-35-3-499 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe subject of symptomatology will always retain its importance in medicine because symptoms form the first contact between patient and doctor. It is the voice of nature, and when a patient complains he enters our world and we recognize a human need. For convenience I shall apply the term "symptom" to subjective sensations of which the patient complains. While everyone agrees on their value in approaching a diagnosis, symptoms have been moved to the background by current interest in signs and in scientific technic. But if we apportion too little time for eliciting symptoms, we shall suffer in our diagnosis.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JOHN PARKINSON, M.D., F.R.C.P., F.A.C.P. (honorary)Affiliations: London,*Presented at the Thirty-second Annual Session of the American College of Physicians, St. Louis, Mo., April 9, 1951. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEditorialDie Coronarerkrankungen. Coronarinsuffizienz, Angina pectoris und HerzinfarktTHE CODEXCHEST PAINCARDIAC AND NON-CARDIAC CHEST PAIN: A STATISTICAL STUDY OF "DIAGNOSTIC" CRITERIA*ARTHUR M. MASTER, M.D., F.A.C.P., HARRY L. JAFFE, M.D., LEON PORDY, M.D.Chest Pain—Cardiac vs. Noncardiac 1 September 1951Volume 35, Issue 3 Page: 499-506 ePublished: 1 December 2008 Issue Published: 1 September 1951 Copyright & PermissionsCopyright, 1951, by The American College of PhysiciansPDF downloadLoading ...
The mechanism of hypophosphatemia in acute heat stroke
Authors: J. P. Knochel
Journal: JAMA (1977)

Severe heat stroke may be associated with hypophosphatemia and hypocalcemia. Hypophosphatemia is generally observed within hours after onset, but hypocalcemia usually occurs on the second or third day, and after hypophosphatemia has undergone spontaneous correction. A young man displayed respiratory alkalosis during the course of severe heat stroke. The hypophosphatemia abated spontaneously as metabolic acidosis and acute renal failure supervened. Hypocalcemia became prominent and was more severe than that ascribable to uremia. Hypocalcemia was probably the result of calcium phosphate and calcium carbonate deposition in injured skeletal muscle. (<i>JAMA</i>238:425-426, 1977)
Lumbago
Authors: W. Newman
Journal: BMJ (1859)

sion, so th-at nio fistuilois channel was left.In the only other case that we rememnber to lhave seen, which occurred some Years ago in the praetice of MNr.Cesar Hawkins, a fistula was left; and the cause of it was only recognised at the operation.in that case, the patient was qtuite unaware of the accident whicih had led to his complaint.An elderly wom-lan, agecl (S, of intemperate habits, was ad- uhitte(l under Mr. Blarker's care, on account of suppuration in the right isAtes, niear the rectulmii.Oni inquiry, it wvas found that slhe had been eating a sole, for dinner, wlhen a bone stuck inl her throat, anid wotul(d neither go uip nor down for some timne.Finally it went down, and she thlought no more about it, only that she felt ani occasional uneasy sensation about tlhe epigastriiubn.This occurred more tlhan a fortnight before admis- sion.When a(dmitted, slhe was low and feeble, and erysipelas was extendin-over the surface of the skin in the neighbourhood of the diseased parts.No distinct fluctuation could be felt, but the presenee of deep seated Ilmatter was indicated by the doughy sen-ation presentedl.A deep incision was accordingly made by thle sidle in the rectuim ; anid, in doinlg so, a foreign i)ody was fohind, wlhiel grated againist the knife.1'ressnre was made t(' evaentate the mnatter; anid a fish-bone, tfio inelles in length., lprotrtulded fromn the wounid.On this being extracted, thle patient related tlhe fore-oing history.The wi-ound healed v-ery quickly, and no fistiilous commlrrunication was left.The patient was soOn in perfect health. ST. 1MARY'S HOSPITAL.DOIS6ONING BY ACONITE-ROOT.[irmo the Hospital Post-3Moirtein and Case-Book.]Tiirm folloAwing, case is reported in order to put on record the post qnIortcin appearances whicih follow the operation of this p)ison, aind of which few, if any, perfectly full accounts ap- pear to liave, been oet ptiblishied.The case is otherwise of nio partiulcar inter st, as the patient (who was nominally under 11)r.Aldersoils c.re) was seen far too late for any good to be expected froini any kind of treatment.Janies 10 s,e(-d iS was admitted, under the care of Dr. Alderson, on Jtily 11tl, at five milinutes before one in the inornins.lie,was a gardener, ancl acquainted -with the pro- PerticsosLf plants andic, being in great distress, liad dug up a
OBSERVATIONS ON THE SALT CONTENT OF HUMAN MILK
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SCIENTIFIC USE OF HOSPITALS.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
EIGHTEENTH CENTURY MEDICAL EDUCATION IN ENGLAND.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Obituary Listing
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Cyclopedia of Medicine.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Letter: Postmortem examination
Authors: Jack Hasson
Journal: JAMA (1976)

<h3>To the Editor.—</h3> Burrows pointed out that autopsies are expensive and that they consume a considerable amount of the pathologist's time. I agree with these premises but I disagree with his suggestion that the solution is the selection of "clinically puzzling" cases for study, while excluding from study at autopsy cases that are "routine." Britton,<sup>1,2</sup>a Swedish pathologist, in a study of 383 autopsy cases among 400 consecutive deaths (an autopsy rate of 93%), in contrast to Dr Burrows' lone effort, worked with a panel of clinicians. Clinical diagnoses were classified<i>by the clinicians</i>as "fairly certain" or "probable." The "fairly certain" category is comparable to what others refer to as "routine" cases. The total error rate was 25% in the "fairly certain" category, and 45% in the "probable" category. Britton quite rightly points out that "Obviously, such cases cannot be excluded from autopsy on the grounds that errors
A phase I/II study of nintedanib and capecitabine in refractory metastatic colorectal cancer.
Authors: Patrick McKay Boland, Marwan Fakih, Dean Lim, Kristopher Attwood, Wei Tan, Michalis Mastri, Robert Bies, Christos Fountzilas, Renuka V. Iyer, Wen Wee Ma
Journal: Journal of Clinical Oncology (2018)

3552 Background: Refractory metastatic colorectal cancer patients (mCRC) have a median survival of 4-6 months. Nintedanib is a TKI which inhibits VEGFR, PDGFR, and FGFR with preclinical efficacy in bevacizumab resistant CRC. This phase I/II study sought to evaluate the recommended phase II dose (RP2D) and efficacy of nintedanib and capecitabine in refractory mCRC patients. Methods: Key eligibility criteria included histologically proven mCRC, ECOG PS of 0 or 1, progression/intolerance to a fluoropyrimidine, oxaliplatin, irinotecan, and anti-EGFR therapy for RAS wt patients. Prior regorafenib was exclusionary. The primary endpoint was 18-week progression free survival (PFS). A one-sided binomial test (at α = 0.1) compared the observed 18-week PFS to a historic control of 0.25. Secondary endpoints included median PFS, median OS, ORR, and AE profile. Results: 40 patients were enrolled across 2 dose levels. Nintedanib 200 mg po bid and Capecitabine 1000 mg/m2 po bid was established to be the RP2D. 36 patients were treated at the RP2D and evaluable for efficacy. The 18 week progression free survival (PFS) was 36% (13/36 patients), p = 0.0922, indicating a statistically significant increase in PFS over historic control. No responses were observed; 19 (53%) patients experienced SD. Median PFS was 3.3 mos. Median OS was 7 mo. 16 (44%) patients experienced a grade 3/4 AE, with the most common evens being fatigue (8%), palmoplantar erythrodysesthesia (8%), AST elevation (6%), asthenia (6%), pulmonary embolus (6%), and dehydration. PK/PD and plasma biomarker data will be presented. Conclusions: The combination of Capecitabine and Nintedanib was well tolerated. Efficacy compares favorably to historic data with regorafenib or TAS-102 monotherapy and is similar to results from other investigations of multi-kinase TKIs and flouropyrimidines in the refractory setting. Further investigation is warranted. This study was approved and funded by the National Comprehensive Cancer Network (NCCN) Oncology Research Program from general research support provided by Boehringer Ingelheim Pharmaceuticals, Inc. Clinical trial information: NCT02393755.
MICROBIC VIRULENCE AND HOST SUSCEPTIBILITY IN PARATYPHOID-ENTERITIDIS INFECTION OF WHITE MICE
Authors: Ida W. Pritchett
Journal: The Journal of Experimental Medicine (1926)

In Vol. xliii, No. 2, through an unfortunate oversight, the scale along the ordinate was omitted from Text-fig. 1, between pages 146 and 147, as originally printed. The accompanying slip is arranged to be pasted along the left side of Text-fig. 1. The arrow at the top of the slip should be so placed as to be a continuation of the upper border of the chart. From the scale given in this slip the relative values of the curves shown in Text-fig. 2 (page 148) can be easily determined, since this is merely an enlarged and somewhat compressed portion from the larger text-figure. See PDF for Structure
Circulating thrombin time anticoagulant in a procainamide-induced syndrome
Authors: D. K. Galanakis
Journal: JAMA (1978)

Circulating anticoagulants are unusual in drug-induced syndromes. We evaluated the prolonged thrombin time of plasma from a patient with a procainamide-induced syndrome. This defect was shown to be due to a circulating anticoagulant that was not of fibrin or fibrinogen origin and that prolonged thrombin and reptilase clotting times of plasma. Subclinical doses of heparin sodium induced hemorrhagic manifestations in this patient. Following cessation of heparin therapy, the circulating anticoagulant persisted but the bleeding tendency abated. All clinical and laboratory manifestations of this syndrome abated gradually following cessation of procainamide therapy. (<i>JAMA</i>239:1873-1874, 1978)
Journal of Neurophysiology, Washington
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ACKNOWLEDGMENT: ERRATUM
Authors: WARREN W. FUREY
Journal: Annals of Internal Medicine (1969)

Letters and Comments1 July 1969ACKNOWLEDGMENT: ERRATUMWARREN W. FUREY, M.D.WARREN W. FUREY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-71-1-212_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: In submitting my brief communication, "Anaphylactic Shock Due to Oral Demethylchlortetracycline" (Ann. Intern. Med. 70: 357, 1969), I listed my position as Instructor, Department of Medicine, Northwestern University, as well as my hospital staff appointment to Mercy Hospital & Medical Center. By letter I was informed by your office that I could list only one affiliation. I agreed to this and put my primary listing as Mercy Hospital.My purpose in writing now is to inquire about the reason behind this policy. Several people from Northwestern University have asked why my school was not also mentioned. This... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: 30 North Michigan Chicago, Ill. 60602 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1969Volume 71, Issue 1Page: 212-212KeywordsHospital medicineShock Issue Published: 1 July 1969 PDF downloadLoading ...
In This Issue
Journal: Journal of Clinical Investigation (2010)

COMM(an)D(ing) role in tumor invasionCOMM domain-containing 1 (COMMD1) is the prototypic member of the little studied COMMD family of proteins.COMMD1 inhibits NF-κB and HIF, two transcription factors linked to tumor growth, survival, and metastasis.van de Sluis and colleagues therefore set out to test the hypothesis that COMMD1 is inactivated or repressed in tumors (2119-2130).Their initial analysis of the Oncomine database indicated that COMMD1 expression is decreased in a variety of cancers relative to normal tissue controls.Furthermore, the data from the Oncomine database and analysis of both prostate cancer and endometrial cancer patients indicated that decreased COMMD1 expression is associated with increased tumor invasion and worse clinical outcomes.Consistent with these data and a role for COMMD1 in promoting tumor invasion of the tissues and vasculature, decreasing COMMD1 expression in human cell lines increased tumor invasion in a chick xenograft model, while increasing COMMD1 expression in mouse cells decreased lung metastasis in a mouse model.The authors' observation that decreased COMMD1 expression correlated with increased expression of genes encoding proteins known to promote cancer cell invasiveness provides more evidence to support their conclusion that COMMD1 has a role in tumor invasion.
Toxic psychosis due to diphenhydramine hydrochloride
Authors: S. A. Nigro
Journal: JAMA (1968)

A patient who had taken an overdose of diphenhydramine hydrochloride showed schizophrenia-like behavior initially which changed to include features of an acute brain syndrome. Throughout, signs of cholinergic hypofunction were evident. The mental state reverted to normal 29 hours after the ingestion.
Errata
Journal: JNCI Journal of the National Cancer Institute (1974)

In “Neuraminidase-Induced Enhancement of Tumor Growth in Mice,” by Gerd Froese, Istvan Berczi, and Alec H. Sehon, on page 1905, line 7 of the Summary and line 1 of the text, Vibrio comma should read Vibrio cholerae.
Abstract 19521: Slow and Prolonged Inflations of Percutaneous Transluminal Angioplasty is as Effective as Stenting in Peripheral Vascular Interventions
Authors: Perwaiz M Meraj, Rajkumar Doshi, Pavitra Vijayaraghavan, Daniel Helfgott, Niraj Shah
Journal: Circulation (2015)

Background: The benefit of stent implantation over percutaneous transluminal angioplasty (PTA) in patients undergoing peripheral vascular interventions (PVI) has not been well described. Original data supporting stents over PTA was in an era without routine atherectomy, and more recent data including chronic total occlusions (CTO) and longer lengths demonstrated no difference. Method: 551 patients undergoing PVI were identified from January 2011 to January 2015. Success was defined by a composite improvement of ankle brachial index (ABI) to over 0.9, an ultrasound velocity of less than 250 m/s, or Rutherford classification improvement. All PTA was performed over a slow inflation over 5 minutes. A Pearson chi-square and multivariate analyses were used to determine results. Results: 274 (49.72%) patients received PTA alone and 277 (50.28%) received stents. Although more patients with diabetes and longer lesion length were in the PTA group, stenting did not improve the individual or composite success endpoints. Even when correcting for these differences in a multivariate analysis. Conclusion: PTA is as effective as stenting even in patients with diabetes and long lesion lengths (over 100mm). More data is necessary as drug eluting balloon angioplasty has been shown to improve patency over PTA, however the more slow and prolonged inflations in PTA may be responsible for these findings.
A supravital cytodiagnostic stain for urinary sediments
Authors: R. Sternheimer
Journal: JAMA (1975)

A mixture of aqueous solutions of National fast blue, a copper-phthalocyanine dye, and pyronin B, a red xanthene dye, when added to fresh urinary sediment, supravitally stains benign or malignant cells and the various types of casts and their inclusions. The stain facilitates identification of the formed elements and particularly aids in the differentiation of polymorphonuclear leukocytes from lymphocytes, histiocytes, plasma cells, and renal tubular cells. A variable staining of casts and their inclusions has been observed. Tumor cells may be recognized by nuclear abnormalities or, in case of hyperchromatic tendency, by a very rapid and early uptake of dye preceding that of the surrounding cells. The staining method is rapid and simple enough for routine urinalysis and screening procedures. (<i>JAMA</i>231:826-832, 1975)