tbuckley/cabot-search huggingface dataset:
The Relationship between Levels of the Anti-HIV Drug Indinavir in Patients' Hair and Response to Treatment
Journal: Annals of Internal Medicine (2002)

Summaries for Patients15 October 2002The Relationship between Levels of the Anti-HIV Drug Indinavir in Patients' Hair and Response to TreatmentSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-137-8-200210150-00004 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Human immunodeficiency virus (HIV) infection interferes with a person's immune system. Fortunately, treatment with combinations of several anti-HIV drugs greatly improves health outcomes for people with HIV infection. Unfortunately, patients have difficulty taking the drugs correctly. Treatment success depends heavily on patients' taking the anti-HIV drugs exactly as prescribed and absorbing appropriate amounts of the drugs. Low levels of the drugs in the patient's body can be due to missed doses or to problems with absorption of the drugs into the body. Patients who miss doses of anti-HIV ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Relationship between Levels of Indinavir in Hair and Virologic Response to Highly Active Antiretroviral Therapy.” It is in the 15 October 2002 issue of Annals of Internal Medicine (volume 137, pages 656-659). The authors are L Bernard, A Vuagnat, G Peytavin, MC Hallouin, D Bouhour, TH Nguyen, JL Vildé, F Bricaire, G Raguin, P de Truchis, D Ghez, M Duong, and C Perronne.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoRelationship between Levels of Indinavir in Hair and Virologic Response to Highly Active Antiretroviral Therapy Louis Bernard , Albert Vuagnat , Gilles Peytavin , Marie-Charlotte Hallouin , Damien Bouhour , Thu Huyen Nguyen , Jean Louis Vildé , François Bricaire , Gilles Raguin , Pierre de Truchis , David Ghez , Michel Duong , and Christian Perronne Metrics 15 October 2002Volume 137, Issue 8Page: I-48KeywordsBloodDrug absorptionDrugsHIVHIV infectionsHighly active antiretroviral therapyImmune systemLaboratory testsPatientsTherapeutic drug monitoring ePublished: 15 October 2002 Issue Published: 15 October 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Battling over asbestos in the third world.
Journal: Environmental Health Perspectives (1997)

uhLs exeimns A e_ttsia ehd en htsm eeeviomn tde ao bednewthu sujcs havngto rvdlodsmls out a questionnaire on exposure than it is to collect blood samples and perform genetic analysis, Umbach and Weinberg propose a research method in which a control group is used but not asked to supply tissue samples.This method should erase most of the anxi- ety for controls, while allowing the effect of the gene-exposure interaction, as well as the effect of the exposure alone, to be evaluated.For example, in a study of how smoking and a particular gene interact to cause lung cancer, if the assumption of random occur- rence of the gene among smokers and nonsmokers can be made, the combined effect of the gene and smoking could be found with- out using a control group.However, what Weinberg and Umbach propose is that a control group be used, but only to fill out questionnaires about their smoking histories.This would allow the researchers to also ana- lyze what effect smoking alone has on the incidence of lung cancer.The major draw- back of this method is that it could not be used to determine the effect of the genotype alone, independent of smoking, as this would require collecting genetic information from the control group.However, even in studies in which uncovering the lone genotype effect is important, Umbach and Weinberg report that researchers can still save controls some anxiety.This is because, even though the genotype of controls is necessary to find the genotype effect, it is not necessary to link those genotypes to specific exposures or, hence, to the individuals that supplied them.Genetic information can be collected from a control anonymously, without so much as a number to link the data to a specific individ- ual or exposure history.The important infor- mation for determining the genotype effect,
Treatment of Verrucae With Smallpox Vaccine
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
WHEN AND HOW PHYSICIANS DIE.
Journal: JAMA (1903)

During 1902 the deaths of 1,400 regular practitioners of the United States were noticed inThe Journal. This is probably within 5 per cent, of the total mortality in the profession of the country, as our facilities for obtaining notices of deaths are very complete. The total number of physicians in the United States is probably about 105,000, and the number of regular practitioners about 95,000. Consequently, the death rate for the year was about 14.74 per 1,000, a lower rate than is usually supposed to obtain in the profession. The statistics of life insurance companies claim a mortality rate per thousand among physicians of 7 at the age of 25; 15 at the age of 35; 21 at the age of 45; 34 at the age of 55, and 112 at the age of 65. The statistics of the United States Census of 1900 show figures which closely parallel
Two Lectures on Tumours of the Larynx: Their Pathology, Symptoms, and Treatment, with Illustrative Cases
Authors: D. Newman
Journal: BMJ (1886)

dimness of sight, and absence of the patellar reflex, indicate moxe extensive disease.On mnicroscopical examination, the spinal cord proves to be the seat of very widespread changes; and yet the parts affected are so con- stant throughout, that the atfection cannot be looked upon as an in- discriininate one, but must be placed amona the more complicated comnbined system-diseases.It will be seen 2y reference to Fig. 33 that the regions affected are (1) the lateral columns : (2) the posterior columns ; (3) the direct pyramnidal tracts ; (4). the anterior root-zones aind (5) in a minor degree, the grey matter of the anterior cornu.But it will also be observed t%at, in the neighbourhood of the grey matter everywhere, a zone remains lhealthy, and, in addition, a super- ficial tract of fibres situated between the crossed pyramidal and cerebellar tracts posteriorly, and the anterior root-zones anteriorly, is un- altered.The pathological changes throughout the diseased arein are
17. Antimicrobial Sensitivity Tests and Therapy Monitoring
Journal: JAMA (1977)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A multicenter randomized controlled trial of recombinant interferon-α2b in patients with acute transfusion-associated hepatitis C
Authors: P Lampertico
Journal: Hepatology (1994)

To assess whether interferon-α might prevent non-A, non-B hepatitis from becoming chronic, 45 consecutive patients with transfusion-associated hepatitis were enrolled in a randomized clinical trial. Thirty-eight patients had hepatitis C virus infection, and 7 had non-A, non-B, non-C hepatitis. Twenty-six patients (22 with HCV) were given 3 MU of recombinant interferon-α2b three times a week for 12 wk, whereas 19 (16 with HCV) were not. Biochemical and virological parameters were monitored at regular intervals during an 18-mo follow-up. At the end of the 3-mo therapy, 16 (73) patients with hepatitis C had normal serum ALT activity, compared with 7 (44) who were not treated (NS). Fifty-three percent of the treated patients and none of the untreated patients had normal ALT levels and no HCV RNA (p = 0.0087). At the end of the 18-mo follow-up, 13 (59) treated patients had normal ALT levels, compared with 6 (37) untreated controls (NS). Thirty-nine percent had normal ALT and no HCV RNA, compared with none of the controls (p = 0.035). Four patients (22) had had sustained complete responses to interferon, defined as normal ALT levels and no HCV RNA at the end of the 3-mo treatment period and the 18-mo follow-up period. All seven patients with non-A, non-B, non-C hepatitis, treated and untreated, recovered uneventfully from hepatitis. One major finding was that short-term treatment with interferon-α was effective in most patients with acute hepatitis C and led to complete recovery from hepatitis in 39 of the cases. (Hepatology 1994;19:19–22).
In Situ Gene Therapy via AAV-CRISPR-Cas9-Mediated Targeted Gene Regulation
Authors: Ana M. Moreno, Xin Fu, Jie Zhu, Dhruva Katrekar, Yu-Ru V. Shih, John Marlett, Jessica Cabotaje, Jasmine Tat, John Naughton, Leszek Lisowski, Shyni Varghese, Kang Zhang, Prashant Mali
Journal: Molecular Therapy (2020)

(Mol Ther. 26, 1818–1827; July 5, 2018) In this article, the Animal Experiments section, subheading “AAV Injections,” originally read “All animal procedures were performed in accordance with protocols approved by the Institutional Animal Care and Use Committee (IACUC) of the University of California, San Diego and adhered to the ARVO Statement for the Use of Animals in Ophthalmic and Vision Research.” The online text has been updated to read “All animal work was pursuant to protocols ultimately approved by the IACUC of the University of California San Diego. However, there were deviations from the approved protocol of Dr. Zhang related to retinitis pigmentosa on mouse neonates (P7) before those deviations were incorporated in an amended protocol, which was promptly approved by the University of California San Diego IACUC.” In Situ Gene Therapy via AAV-CRISPR-Cas9-Mediated Targeted Gene RegulationMoreno et al.Molecular TherapyApril 24, 2018In BriefWe developed a modular adeno-associated viral vector platform for CRISPR-Cas9 delivery to enable targeted in situ gene regulation, demonstrating robust transcriptional repression and activation of genes in cell culture and mice. This approach could potentially enable disease targeting in a genomically scarless and reversible manner. Full-Text PDF Open Archive
Intoxication following ingestion of elemental zinc
Authors: J. V. Murphy
Journal: JAMA (1970)

A 16-year-old boy ingested 12 gm of metallic zinc in an attempt to hasten healing of a minor laceration. Lethargy occurred several days after the ingestion, and was accompanied by an elevated zinc concentration in whole blood. Chelation therapy promoted dramatic clinical improvement, and a fall in blood zinc levels.
Nuclear translocation of AMPK-a1 potentiates striatal neurodegeneration in Huntington's disease
Authors: Tz-Chuen Ju, Hui-Mei Chen, Jiun-Tsai Lin, Ching-Pang Chang, Wei-Cheng Chang, Jheng-Jie Kang, Cheng-Pu Sun, Mi-Hua Tao, Pang-Hsien Tu, Chen Chang, Dennis W. Dickson, Yijuang Chern
Journal: The Journal of Experimental Medicine (2011)
Inorganic Particles in Human Tissues and Their Association with Neoplastic Disease
Authors: Arthur M. Langer
Journal: Environmental Health Perspectives (1974)

An increased gastrointestinal cancer risk is associated with occupational exposure to asbestos fiber. Examination of tissues obtained from extrapulmonary organs of exposed workmen demonstrates the presence of asbestos fibers and bodies. The amount of fiber present in these tissues is many magnitudes less than encountered in the lung tissues from the same individuals. Ingestion of asbestos fiber in some environmental instances may approach in magnitude the amount resulting from occupational exposure. Disease factors are discussed.
Tenth Annual Infectious Diseases in Clinical Practice
Journal: JNCI Journal of the National Cancer Institute (1986)

Tenth Annual Infectious Diseases in Clinical Practice Get access JNCI: Journal of the National Cancer Institute, Volume 77, Issue 6, December 1986, Page 1315, https://doi.org/10.1093/jnci/77.6.1315 Published: 01 December 1986
PRURIGO SECANDI
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Of physicians and politics
Authors: J. P. Callan
Journal: JAMA (1979)

Ten years ago at a scientific meeting, a chairman complained about impending cutbacks in government funding for research. He urged delegates to contact their congressmen so that their investigative integrity and independence might be preserved. Then the presiding officer was amazed to hear the highly intelligent, superbly educated researchers admit one after another, like dominoes falling, that they did not even know the names of their congressmen. In the late 1960s, psychiatry came under attack. It was the first medical specialty to be besieged by dissident consumer groups and coalitions of radicals who challenged its practices and policies. The nonpsychiatric medical community stood by, even judging some of the onslaught to be appropriate. Many physicians considered psychiatry outside the pale of medicine; they remained indifferent to the assaults, leaving psychiatry to fend for itself. In the mid-1970s, experienced, diligent obstetricians, insisting on maintaining high standards by not exposing newborns to
Not a Case of Death from Nitrous Oxid.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A GAUZE SPONGE FORMING THE NUCLEUS OF A VESICAL CALCULUS
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Convulsive disorders and participation in sports and physical education
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SURG-09. CORTICOSPINAL TRACT TOLERANCE TO CATHETER POSITIONING FOR CONVECTION ENHANCED DELIVERY IN THE BRAIN STEM
Authors: Peter Morgenstern, Eva Wembacher-Schroeder, Vincent Cina, Mark Souweidane
Journal: Neuro-Oncology (2017)

Convection enhanced delivery (CED) has recently been explored as a therapeutic strategy for children with diffuse intrinsic pontine glioma (DIPG). An anterior or supratentorial approach for catheter positioning risks conflict with descending white matter bundles where they become concentrated in the internal capsule and crural pyramid. We describe our experience planning catheter trajectories in the context of eloquent structures and outcomes this patient population. As part of a Phase 1 clinical trial using CED with 124I-8H9, a radiolabeled monoclonal antibody (NCT01502917), a flexible step-design infusion catheter (Brainlab Flexible Catheter, BrainLab, Munich, Germany) was surgically placed via a supratentorial approach. Surgical planning was conducted based on 3D T1, T2, and SWI sequences. A fully compatible MR-guidance platform was used for trajectory planning catheter deployment. A neurologic exam was performed immediately post-procedure, prior to initiating infusion, to assess for procedure-related deficits. Intra- and post-procedural MR images were analyzed for the anatomic position of catheter trajectories. Conflicts between the catheter tract and the posterior limb of the internal capsule and the pyramid of the crus cerebri were recorded. Correlation between motor deficits and the catheter path was evaluated. Thirty catheter insertions were performed for children with DIPG. Nine patients (30%) experienced transient hemiparesis associated with drug infusion, but no permanent deficits were identified. The posterior limb of the internal capsule and the pyramid of the crus cerebri frequently overlapped the catheter tract without incident. Transgression of descending corticospinal motor tracts by catheters for intracranial infusion is acceptable. We observed that a supratentorial approach to the brainstem crossing eloquent fibers resulted in one neurologic deficit. There does not appear to be a functional risk requiring a need for avoidance of the dominant motor fiber tracts during trajectory planning.