tbuckley/cabot-search huggingface dataset:
Response
Authors: V. Moebus, C. Jackisch, A. Schneeweiss, J. Huober, H.-J. Lueck, A. du Bois, C. Thomssen, C. Kurbacher, W. Kuhn, U. A. Nitz, I. B. Runnebaum, A. Hinke, R. Kreienberg, M. Untch
Journal: JNCI Journal of the National Cancer Institute (2014)
THE "CONSCIENTIOUS OBJECTOR" TO VACCINATION.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MECHANISM OF THE SEROLOGIC TESTS IN SYPHILIS
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Middle mediastinal lesion
Authors: J. C. Reed
Journal: JAMA (1974)

<h3>Common</h3> Aneurysm of aorta or major arteries; right aortic arch Azygos vein enlargement Bronchogenic cyst Esophageal lesion (eg, leiomyoma, carcinoma, achalasia, varices) Hiatal hernia Lymph node enlargement Thyroid tumor <h3>Uncommon</h3> Chemodectoma Enteric cyst Hematoma Sclerosing inflammatory mass; mediastinal abscess or fibrosis Mesenchymal tumor Pancreatic pseudocyst Parathyroid tumor Tracheal tumor or cyst Vagus or phrenic neurinoma <h3>Diagnosis</h3> Bronchogenic cyst. <h3>Comment</h3> In analyzing the gamut of this case, the retrocardiac position of the mediastinal mass is especially helpful, since this location effectively excludes such possibilities as large azygos vein, thyroid tumor, tracheal tumor or cyst, and parathyroid tumor. Lymph node enlargement is the most common cause of a middle mediastinal mass, but enlarged mediastinal nodes will usually be found around the carina tracheae or in the paratracheal area and are frequently accompanied by a more generalized adenopathy, including the parahilar nodes. Hiatal hernia occurs in the retrocardiac area
The human genome project. Prospects and implications for clinical medicine
Authors: E D Green, R H Waterston
Journal: JAMA (1991)

The recently initiated human genome project is a large international effort to elucidate the genetic architecture of the genomes of man and several model organisms. The initial phases of this endeavor involve the establishment of rough blueprints (maps) of the genetic landscape of these genomes, with the long-term goal of determining their precise nucleotide sequences and identifying the genes. The knowledge gained by these studies will provide a vital tool for the study of many biologic processes and will have a profound impact on clinical medicine. (<i>JAMA</i>. 1991;266:1966-1975)
Advisory Committee on Immunization Practices Recommended Immunization Schedule for Children and Adolescents Aged 18 Years or Younger — United States, 2019
Authors: Candice L. Robinson, Henry Bernstein, José R. Romero, Peter Szilagyi
Journal: MMWR Morbidity and Mortality Weekly Report (2019)

At its October 2018 meeting, the Advisory Committee on Immunization Practices (ACIP)* voted to recommend approval of the Recommended Immunization Schedule for Children and Adolescents Aged 18 Years or Younger, United States, 2019. The 2019 child and adolescent immunization schedule summarizes ACIP recommendations, including several changes from the 2018 immunization schedule,† on the cover page, three tables, and notes found on the CDC immunization schedule website (https://www.cdc.gov/vaccines/schedules/index.html). This immunization schedule is recommended by ACIP and approved by the CDC Director, the American Academy of Pediatrics, the American Academy of Family Physicians, and the American College of Obstetricians and Gynecologists. Health care providers are advised to use the tables and the notes together.
History
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
More on nutrition in medical schools
Authors: C. K. Cyborski
Journal: JAMA (1977)

In the November 29 issue of<i>JAMA</i>(236:2534, 1976), an editorial, "Nutrition Instruction in Medical Schools—1976," stated that only 42% of US medical schools offer courses in nutrition. This study was based on the responses from 44 of 60 medical schools surveyed. In early 1976 a survey of the 114 US medical schools was undertaken by myself to determine the amount of nutrition being taught in the medical school curriculum. From the 102 responses, the following data were obtained: (1) 19% of the medical schools have a required nutrition course; (2) 70% have an elective nutrition course; (3) 95% incorporate nutrition into another course (some schools offer nutrition to the students in two or more of these ways); (4) 28% offer clerkships in nutrition; (5) 80% provide students with opportunities for doing nutrition research; (6) 31% offer postgraduate or continuing education studies in nutrition. While it is clear that the
Neurosecretion: Beginnings And New Directions In Neuropeptide Research
Authors: B Scharrer
Journal: Annual Review of Neuroscience (1987)

The brain's default mode network consists of discrete, bilateral and symmetrical cortical areas, in the medial and lateral parietal, medial prefrontal, and medial and lateral temporal cortices of the human, nonhuman primate, cat, and rodent brains. Its ...Read More
The Cost of Disposables
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Infra-Red Irradiation
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Treating Myositis Ossificans—The Charley-Horse of Football
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Role of interferon alpha on arachidonic acid metabolites production by monocytes during chronic hepatitis C 1. 1CJF INSERM 91-07, 2Service d'H�pato-Gastroent�rologie, 3Service de M�decine Interne, Toulouse, France
Journal: Hepatology (1995)

We have examined the effect of several blockers of voltage-sensitive calcium channels on the release of acetylcholine and ATP from synaptosomes isolated from Torpedo marmorata electric organ. Depolarization of these nerve terminals with high K+ -containing solutions resulted in a calcium-dependent release of both molecules. Cadmium ions (10−6 to 10−3 M) inhibited similarly both releases whereas nickel ions (10−4 M) in the external medium did not affect either neurotransmitter or nucleotide release. Both releases were completely resistant to the effect of 1,4-dihydropyridines (antagonists nimodipine, nifedipine and agonist Bay K 8644) and of a related compound (diltiazem) at concentrations up to 10−5 M. These drugs failed to cause any effect even when synaptosomes were submaximally depolarized during incubation. Omega-conotoxin (10−8 to5 × 10−5 M) showed a differential effect on acetylcholine and ATP releases. Nucleotide release was inhibited 90% ai the highest concentration tested (50 μm) while acetylcholine release was only moderately decreased (30%).ec50 values for acetylcholine and ATP were of 167 and 2 μM respectively.The results suggest the implication of different types of calcium channels in the release of these molecules.
Poor immunogenicity of a self/tumor antigen derives from peptide–MHC-I instability and is independent of tolerance
Authors: Zhiya Yu, Marc R. Theoret, Christopher E. Touloukian, Deborah R. Surman, Scott C. Garman, Lionel Feigenbaum, Tiffany K. Baxter, Brian M. Baker, Nicholas P. Restifo
Journal: Journal of Clinical Investigation (2004)

Understanding the mechanisms underlying the poor immunogenicity of human self/tumor antigens is challenging because of experimental limitations in humans. Here, we developed a human-mouse chimeric model that allows us to investigate the roles of the frequency and self-reactivity of antigen-specific T cells in determination of the immunogenicity of an epitope (amino acids 209–217) derived from a human melanoma antigen, gp100. In these transgenic mice, CD8+ T cells express the variable regions of a human T cell receptor (hTCR) specific for an HLA-A*0201–restricted gp100209–217. Immunization of hTCR-transgenic mice with gp100209–217 peptide elicited minimal T cell responses, even in mice in which the epitope was knocked out. Conversely, a modified epitope, gp100209–217(2M), was significantly more immunogenic. Both biological and physical assays revealed a fast rate of dissociation of the native peptide from the HLA-A*0201 molecule and a considerably slower rate of dissociation of the modified peptide. In vivo, the time allowed for dissociation of peptide-MHC complexes on APCs prior to their exposure to T cells significantly affected the induction of immune responses. These findings indicate that the poor immunogenicity of some self/tumor antigens is due to the instability of the peptide-MHC complex rather than to the continual deletion or tolerization of self-reactive T cells.
Potable water as a source of Legionnaires' disease
Authors: K. N. Shands
Journal: JAMA (1985)

A three-year epidemic of legionnaires' disease in a hospital was dramatically curtailed following hyperchlorination of the potable water supply. The hypothesis that potable water was the source for the outbreak was further supported by isolation of<i>Legionella pneumophila</i>(the agent of legionnaires' disease) from the hospital water supply, observation that a sudden upsurge had occurred in the number of cases following a peculiar manipulation of the hospital water system, and documentation of a 30-fold increase in concentration of organisms in the water when this manipulation was artificially recreated. Thus, potable water may be an important source of epidemic legionnaires' disease and continuous hyperchlorination a method of control. (<i>JAMA</i>1985;253:1412-1416)
Abstract 2528: Mapping tumoral and immune heterogeneity in PD-1 responsive glioblastoma
Authors: Paula Restrepo, Raymund Yong, Ilaria Laface, Nadejda Tsankova, Sacha Gnjatic, Adilia Hormigo, Bojan Losic
Journal: Cancer Research (2019)

Abstract Clonal evolution and the immune microenvironment in glioblastoma (GBM) ultimately determine the potential benefit of checkpoint inhibition. We present a case study of a 67- year-old patient who underwent a resection of a large right temporal GBM. The patient received standard-of-care treatment consisting of tumor resection, radiation therapy and concurrent temozolomide. Her tumor recurred as a gliosarcoma after 2 cycles of adjuvant Temozolomide. Subsequently, she received 26 cycles of a PD-1 checkpoint inhibitor and 20 cycles of bevacizumab, a VEGF-A inhibitor. She survived 25 months after diagnosis including six after immunotherapy and VEGF-A blockade was discontinued. We integrated RNA-seq and whole exome sequencing data from the primary tumor and several recurrent biopsies to characterize the genomic and molecular landscape within the context of clonal evolution. Specifically, we surveyed tumor-immune interactions by computing the mutational and neo-epitope tumoral burden, along with the magnitude and clonality of infiltrating lymphocytes using VDJ-sequencing. Furthermore, we intersected genomic instability measures with the regional gene expression profiles among the sectors. Finally, we integrated TCGA-GBM RNA-seq data to examine the expression of our patient sectors among the spectrum of known GBM variation. We found significant regional heterogeneity in the predicted neoantigen and infiltrating lymphocyte landscape, with a pronounced shift towards lower predicted immunogenicity and lower immune infiltration in all recurrent biopsies. We also observed profound large-scale immune variance among the regional sectors when examined in the context of TCGA. Overall, this case study quantifies intra-tumoral clonal and immune heterogeneity with multiregional glioblastoma omics data, providing reasonable priors for further assessing the efficacy of checkpoint inhibition for GBM. Citation Format: Paula Restrepo, Raymund Yong, Ilaria Laface, Nadejda Tsankova, Sacha Gnjatic, Adilia Hormigo, Bojan Losic. Mapping tumoral and immune heterogeneity in PD-1 responsive glioblastoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2528.
Minimal Residual Diease Evaluation By Flow Cytometry Is a Complementary Tool To Cytogenetics For Treatment Decision In Acute Myeloid Leukemia
Authors: María-Belén Vidriales, Estefania Perez-Lopez, Carlota Pegenaute, Marta Castellanos, Jose Juan Perez, Mauricio A Chandía, Joaquín Díaz-Mediavilla, Consuelo Rayon, Natalia Heras, Pascual Fernandez, Miguel Cabezudo, Alfonso Garcia de Coca, Jose M Alonso, Carmen Olivier, Jesus Hernandez, Marcos González, Guillermo Martin, Rosa Fernandez, Julio García-Suarez, Magdalena Garcia, Maria-Jose Sayas, Alberto Orfao, Jesus F San Miguel
Journal: Blood (2013)
CSIG-48. PHOSPHORYLATION OF EZH2 PROMOTES GLIOBLASTOMA STEM-LIKE CELLS SELF-RENEWAL THROUGH NF-κB METHYLATION
Authors: Hailong Liu, Youliang Sun, Hongyu Yuan, Angela Yue, Chunjiang Yu, Chunyu Gu
Journal: Neuro-Oncology (2018)

PURPOSE: The oncogenic role of MELK/EZH2/NF-κB signaling in the self-proliferation of glioma stem-like cells (GSCs) was discovered to validate the pathway as a therapeutic target and prognostic candidate for glioblastoma. EXPERIMENTAL DESIGN: Expressing exploration and survival analysis were performed to evaluate the association of MELK/EZH2/NF-κB enrichment with the prognostic value in glioma samples. The dynamic expression of MELK/EZH2/NF-κB at the stem-cell assembled regions during mouse brain development was detected to estimate the proliferative potential of the axis. Mechanistic interacting course was examined using the RNA knockdown and immunoblot techniques to confirm the signaling impacting the GSCs self-proliferation. The progression of xenografts derived from human GSCs was examined after genetic or drug blockage of MELK/EZH2/NF-κB signaling in GSCs. We reported that EZH2 phosphorylated by MELK bound to NF-κB methylating it in GSCs, which promoted its ability to mediate the development of glioblastoma. Striking parallels regarding the enrichment of MELK/EZH2/NF-κB axis between GSCs and normal stem cells indicated the association of the pathway with stemness. Clinically, the proportion of MEKL/EZH2/NF-κB signaling elevated progressively during the increasing glioma grades and could be considered as the potential indicator of survival. In addition, functional loss of this axis effectively impaired the proliferation of GSCs. CONCLUSION: Our findings show that the MELK/EZH2/NF-κB interaction is required for the GSCs derived neoplastic proliferation, thereby uncovering in the signaling a therapeutic candidate to treat this malignancy.
Parkinson Disease
Authors: Joan Stephenson
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Index of Authors&lt;subtitle&gt;Volume 19 July 1957 • December 1957&lt;/subtitle&gt;
Journal: JNCI Journal of the National Cancer Institute (1957)

Index of Authors: Volume 19 July 1957 • December 1957 Get access JNCI: Journal of the National Cancer Institute, Volume 19, Issue 6, December 1957, Pages 1149–1151, https://doi.org/10.1093/jnci/19.6.1149 Published: 01 December 1957