tbuckley/cabot-search huggingface dataset:
THE EFFECTS OF COFFEE ADDICTION.
Journal: JAMA (1890)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
02.08 The paracaspase malt1 plays a central role in the pathogenesis of rheumatoid arthritis
Authors: Elisabeth Gilis, Jens Staal, Rudi Beyaert, Dirk Elewaut
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Rheumatoid arthritis (RA) is characterised by the activation of auto-reactive T-cells and the development of auto-antibodies. Importantly, T-cells may additionally respond to non-TCR mediated signals, which are essential in driving their effector functions. Pathways leading to the modulation of both innate and adaptive signals are therefore of marked interest to study in arthritis. The paracaspase MALT1 is a key player in the activation of lymphoid, myeloid and mast cells, indicating MALT1's crucial role in innate and adaptive signalling. Therefore, MALT1 is regarded a promising target for the treatment of autoimmune diseases and defining its role in the pathogenesis of RA is a critical first step. <h3>Methods</h3> To unravel MALT1's role in RA, we initially assessed MALT1-activation in mice challenged with collagen-induced arthritis (CIA), the prototype model for RA. We then sought to address MALT1's role in the pathogenesis of RA by subjecting MALT1-deficient mice to distinct models of arthritis (CIA and CAIA). To determine the importance of MALT1 in T-cells, CIA was additionally induced in CD4-specific MALT1-deficient mice. Finally, the effect of MALT1-deletion on bone homeostasis was assessed by measuring bone density by µCT-analysis of the tibiae and by a three-point bending test of the femurs. <h3>Results</h3> We provide evidence that MALT1 is activated in RA and plays a crucial role in its pathogenesis since MALT1-deficent mice were completely protected against CIA. This protection was additionally observed in CD4-specific MALT1-deficient mice, indicating that the selective ablation of MALT1 in CD4-positive cells is sufficient for the observed resistance. CAIA on the other hand, which is a T-cell independent model of RA, did not depend on MALT1 since both MALT1<sup>+/+</sup> and MALT1<sup>-/-</sup> mice showed comparable arthritis symptoms. Paradoxically to the protective effect of MALT1-deletion on inflammation, we show that MALT1-deficiency negatively influences bone density at steady state. More specifically, both the tibiae and femurs of MALT1<sup>-/-</sup> mice had a significantly reduced bone density and strength compared to MALT1<sup>+/+</sup> mice. <h3>Conclusion</h3> Altogether, our data provide evidence for a dual role of MALT1 in arthritis, showing a protective effect of its deletion on the inflammatory aspect and a negative effect on bone homeostasis.
MEDICAL EDUCATION.
Authors: J. R. JONES
Journal: JAMA (1901)

The writer, after considering the several phases of the subject of medical education, registration, etc., as they apply in Canada, said: <h3>PROFESSIONAL EDUCATION.</h3> The medical curriculum has subjects difficult to acquire, worthless as mental gymnastics, useless in practice and speedily forgotten when acquired. The methods of teaching are imperfect and vicious. The student in didactic lectures is not taught—he is over-lectured and under-taught. The lecturer describes rather than demonstrates and instead of making the student follow him step by step in his methods of observation, collecting, comparing, testing, and recording facts and of reasoning thereon, the didactic lecturer leaves them to be learned by being described, forgetful that they can be learned only by being practiced. The main tendency of the present method of didactic lectures is to give students smatterings of scientific knowledge at the cost of that thorough knowledge of their art which is essential to its successful
The prevalence of penicillin-non-susceptible Streptococcus pneumoniae among children aged &lt; 5�years correlates with the biannual epidemic activity of respiratory syncytial virus
Authors: K. Mühlemann, D. E. Uehlinger, W. Büchi, M. Gorgievski, C. Aebi
Journal: Clinical Microbiology and Infection (2006)
Changes in serum fibrogenesis markers during interferon therapy for chronic hepatitis type C
Authors: K Ishibashi
Journal: Hepatology (1996)

We serially measured the levels of serum N-terminal peptide of type III procollagen (PIIINP), the 7S domain of type IV collagen (IV-7S), and hyaluronate (HA) before (0 month), at the end (6 months), and 24 weeks after the end of interferon therapy (12 months) in patients with chronic hepatitis type C to estimate the effects of interferon alfa (IFN-alpha) on serum levels of hepatic fibrogenesis markers. One hundred twenty-one patients with chronic hepatitis type C received intramuscular injection of 6 million U of natural IFN-alpha for 24 weeks. Patients were divided into three groups: sustained complete response (CR-S), complete response with rebound (CR-R), and nonresponse (NR). Serum PIIINP, IV-7S, and HA levels were significantly decreased and reached normal levels at 12 months in CR-S; only IV-7S levels were significantly decreased at 12 months in CR-R, whereas these levels remained abnormally high in the NR. These results suggest that IFN- alpha therapy could lower the levels of serum hepatic fibrogenesis markers along with improvements in hepatic inflammation.
TRANSCATHETER VALVE IN VALVE IMPLANTATION FOR FAILED BIOPROSTHETIC HEART VALVES
Authors: David Alexander Wood, Ronen Gurvitch, Anson Cheung, Jian Ye, Jonathon Leipsic, Eric Horlick, Josep Rodés-Cabau, Eric Dumont, Mark Osten, Olaf Wender, Jean Bernard Masson, Namal Wijesinghe, Edgar Tay, Fabian Nietlispach, Mark Johnson, Brad Munt, Rob Moss, Christopher R. Thompson, Samuel V. Lichtenstein, John G. Webb
Journal: Journal of the American College of Cardiology (2010)
BELGIUM
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Magnesium Metabolism
Authors: Warren E. C. Wacker, Bert L. Vallee
Journal: New England Journal of Medicine (1958)

THE average adult human being has a whole-body content of 25 gm. of magnesium. Magnesium is the fourth of the cations in terms of abundance, exceeded only by calcium, sodium and potassium. Despite its ubiquitous distribution in relatively large amounts, knowledge of its role in physiology and pathology is surprisingly limited.The biological functions of magnesium, particularly its role as an activator in biochemical systems, its pharmacological properties and its function as an essential nutrient for animals and plants have been the subject of intensive investigation. For the most part, this experimental work has not been extended to clinical medicine. . . .
Antiphospholipid antibodies in patients with primary biliary cirrhosis (PBC): marker of advanced liver disease or predictive of progressive liver disease?
Authors: R. Innarella, M. Leto, M. Farina, L. Framarin, A. Mattalia, P.A. Milillo, L. Bonardi, F. Rosina, L. Okolicsanyi
Journal: Journal of Hepatology (2001)
Tetralogy of Fallot: Radiologic Evaluation Before and After Surgical Treatment
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
EAPH-07. CHILDREN’S BRAIN TUMOUR DRUG DELIVERY CONSORTIUM
Authors: Ruman Rahman, Richard Grundy, Emma Campbell, Henry Brem, Monica Pearl, Jordan Green, Miroslav Janowski, Kenneth Cohen, Piotr Walczak, Katherine Warren, Stephen Lowis, Alexander Mullen, Marie Boyd, Gareth Veal, Darren Hargrave, Dannis van Vuurden, Steven Powell, David Walker
Journal: Neuro-Oncology (2018)

There is an urgent need to expedite the development of new or repurposed drugs for children’s cancer. An additional challenge in the developing brain is to ensure the drug is delivered to the tumour at therapeutic and non-toxic concentrations for sufficient duration to achieve the biological effect. Children’s brain tumours account for over 20% of childhood cancers and differ significantly in their biological characteristics from their adult counterparts. The authors participated in an international CNS drug delivery workshop funded by the charity Children with Cancer UK in February 2016, where different experimental techniques aimed at optimising CNS drug delivery in children’s brain tumours were discussed. The workshop was reported by e-cancer (http://ecancer.org/journal/10/full/630-highlights-of-children-with-cancer-uk-s-workshop-on-drug-delivery-in-paediatric-brain-tumours.php; http://ecancer.org/conference/831-drug-delivery-in-paediatric-brain-tumours.php). We were encouraged to develop a proposal to establish an international research consortium to raise awareness and promote collaboration in the field. This is now funded for two years by Children with Cancer UK. The Children’s Brain Tumour Drug Delivery Consortium seeks to strengthen collaborative developments by working closely with the international children’s brain tumour community, encouraging and facilitating discussions between a multi-disciplinary network of clinicians and researchers within pharma and academia as well as a range of funders and stakeholders. As of January 2018, we have 92 individuals from 11 nations registered as members, with diverse stakeholders represented by academics, clinical academics, charities, public/patient groups, industry and regulatory bodies. We present this abstract to the ISPNO conference to promote this initiative in America, widening our invitation for collaborators to join the consortium.
Lineage relationship of CD8+ T cell subsets is revealed by progressive changes in the epigenetic landscape
Authors: Joseph G. Crompton, Manikandan Narayanan, Suresh Cuddapah, Rahul Roychoudhuri, Yun Ji, Wenjing Yang, Shashank J. Patel, Madhusudhanan Sukumar, Douglas C. Palmer, Weiqun Peng, Ena Wang, Francesco M. Marincola, Christopher A. Klebanoff, Keji Zhao, John S. Tsang, Luca Gattinoni, Nicholas P. Restifo
Journal: Cellular and Molecular Immunology (2015)
Handbuch der Geisteskrankheiten.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 1165: Impact of Gender on Serial Atherosclerotic Changes in Response to Established Medical Therapies
Authors: Srinivasa R Kalidindi, Amy Hsu, Keon-Woong Moon, E. Murat Tuzcu, Steven E Nissen, Stephen J Nicholls
Journal: Circulation (2007)

Background: While the importance of coronary artery disease in females has become increasingly recognized, little is known regarding the impact of gender with regard to changes in arterial wall dimensions with progression and regression of atherosclerosis. This study investigated the remodeling response of the artery wall accompanying changes in atheroma burden in response to use of medical therapies, stratified according to gender. Methods: 1533 patients (27.5% female) underwent serial intravascular ultrasound evaluation of a single coronary artery in the context of clinical trials that assess the impact of medical therapies on plaque progression. The relationship between gender and remodeling of the arterial wall at baseline and its serial change in association with plaque progression and regression were studied. Results: Females were older (59 v 57 years, p&lt;0.01), had a higher body mass index (31.5 v 29.5 kg/m 2 , p&lt;0.01), were more likely to have hypertension (86 v 71.5%, p&lt;0.01) and metabolic syndrome (57 v 49%, p&lt;0.01) and less likely to have a history of smoking (57.5 v 73.5%, p=0.01) and myocardial infarction (27.5 v 35.5%, p&lt;0.01). After adjusting for body surface area, females demonstrated a trend towards smaller external elastic membrane (EEM) (226.3 v 234.3 mm 3 , p=0.09) and larger lumen (143.7 v 137.7 mm 3 , p=0.01) volumes. The remodeling index at the most diseased site did not differ between genders (0.95 v 0.95, p=0.95). No differences were observed between genders with regard to changes in EEM (−5.6 v −6.2 mm 3 , p=0.29) and lumen (−4.9 v −4.5 mm 3 , p=0.82) volumes and remodeling index (−0.02 v −0.03, p=0.43) in response to use of medical therapies. Similarly, there were no differences between genders with regard to the percentage of patients undergoing expansion (34.7 v 35.5%, p=0.86) or contraction (20.4 v 21.8%, p=0.69) of lumen volume in association with regression of atherosclerotic plaque. Conclusion: A similar pattern of remodeling of the arterial wall was observed between genders in association with serial changes in atheroscle-rotic plaque. This further highlights our understanding of the pathological interactions between atherosclerosis and the arterial wall in females.
Medical News
Journal: BMJ (1958)

for British Isles for week ending October 11 (No.41) and corresponding week 1957.Figures of cases are for the countries shown and London administrative county.Figures of deaths and births are for the whole of England and Wales (London included), London administrative county, the 17 principal towns in Scotland, the 10 principal towns in Northern Ireland, and the 14 principal towns in Eire.A blank space denotes disease not notifiable or no return available.The table is based on information supplied by the Registrars-General of England and Wales, Scotland, N. Ireland, and Eire, the Ministry of Health and Local Government of N. Ireland, and the Department of Health of Eire.1958 1957 CASES % 0 -.t 0 0 Diphtheria ..
Treatment of Chronic Insomnia With Cognitive Behavioral Therapy vs Zopiclone—Reply
Authors: Børge Sivertsen
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
LEUKEMIA-LIKE SYNDROMES
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
2nd World Congress on Pediatric Intensive Care 1996 Rotterdam, The Netherlands, 23–26 June 1996 Abstracts of Oral Presentations, Posters and Nursing Programme
Authors: G Pearson, P Barry, F Shann, D Field, Study Tv, Reinoud Gemke, Gouke Bonsel, A Van Vught, M Wells, J Lipman, Reinoud Gernke, Van Moudk, M Monkhoff, O B~jaziger, C Morales, A Mfitter, H-U Bucher, S Fanconi
Journal: Intensive Care Medicine (1996)
The prevention of acquired immunodeficiency syndrome in the United States. An objective strategy for medicine, public health, business, and the community
Authors: D. P. Francis
Journal: JAMA (1987)

Human immunodeficiency virus (HIV) is one of the most virulent infectious agents ever encountered. This virus, estimated to kill up to a half of those infected, has spread to more than 1 million Americans. There is no safe and effective treatment. Nor is there a vaccine. From our understanding of HIV transmission, further spread of the virus can be stopped by the use of various techniques. The combined use of education-motivation-skill building, serologic screening, and contact tracing/notification could eliminate or substantially reduce transmission. To accomplish this reduction an immense concerted effort by physicians, public health practitioners, business, and community organizations is required to get across the simple prevention messages. Those messages are: (1) Any sexual intercourse (outside of mutually monogamous or HIV antibody-negative relationships) must be protected with a condom. (2) Do not share unsterile needles or syringes. (3) All women who may have been exposed should seek HIV-antibody testing before becoming pregnant and, if positive, avoid pregnancy. Only through a concerted, vigorous, and sustained prevention program that deals frankly with this problem will those individuals at risk be reached and motivated to take personal responsibility to protect themselves. Without such an effort, acquired immunodeficiency syndrome will continue to kill ever-increasing numbers of Americans. (<i>JAMA</i>1987;257:1357-1366)
Aerosol inhalers.
Authors: S P Newman
Journal: BMJ (1990)

block reduces the effect of sympathetic modulation on receptors and may be of short lived benefit.'7Depletion of noradrenaline in postganglionic sympathetic terminals by a guanethidine block may be effective.'8Neurosurgical operations, including cordotomy and tractotomies, resection ofsensory cortex, and stereotactic operations on the thalamus, have generally given disappointing results, as indicated earlier.Electrical stimulation is often effective in patients with pain of peripheral origin, but not usually in those with central pain.Spinal cord stimulation may be extremely effective in some patients, and the results are longer lasting and cause less disability than neurosurgery9 20 but it is unlikely to help in pain due to spinal cord injury.Intracerebral stimulation (deep brain stimulation) is still considered a somewhat uncertain method oftreatment because of the great variability in reported results.In conclusion, the management of central pain is by no means settled, but it should not be considered a subject of therapeutic nihilism.Much can be done to help the patient- provided that a methodical approach is undertaken and that neurosurgery is considered only as a last resort.