tbuckley/cabot-search huggingface dataset:
Once more, with feeding
Authors: P. L. White
Journal: JAMA (1981)

The difficulties of feeding free-living research subjects is illustrated once again in a study by Sacks et al reported in this issue (p 640). The object was to observe the effects on blood lipids and blood pressure (BP) from feeding beef to vegetarians. Vegetarians, who usually exhibit low plasma cholesterol levels and BP, should be ideal subjects for the study of the isolated effect of eating beef. The difficulties encountered, however, nicely illustrate the problems produced when dissimilar food items are exchanged in control and experimental diets. Four recent studies,<sup>1-4</sup>in addition to that of Sacks et al, explored the effects of meat or other animal products on plasma cholesterol. The experimental conditions differed among all of the studies. Two studies<sup>1,4</sup>other than that of Sacks et al suggest a hypercholesterolemic effect of meat or other animal products, while two do not.<sup>2,3</sup>Examination of each study may
The Coding Audit
Authors: Joan Sumkin
Journal: Annals of Internal Medicine (1998)

Letters1 November 1998The Coding AuditJoan Sumkin, MDJoan Sumkin, MDAurora Medical Group Fond du Lac; Fond du Lac, WI 54935Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-129-9-199811010-00040 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Along with limiting the time available for the patient encounter, Dr. Lai outlines the difficulty that the coding system presents in training the next generation of physicians. Indeed, the punitive nature of the False Claims Act incites physician paranoia with far-reaching implications. Dr. Pippen's well-put plea to “pick our battles” is a cry for action to protect our pledge to Hippocrates. Individual efforts as well as organized lobbying of physicians must continue this national dialogue if we are to prevent a generation of Americans from experiencing the continual disintegration of health care.As physicians, many of us remain ... Author, Article, and Disclosure InformationAuthors: Joan Sumkin, MDAffiliations: Aurora Medical Group Fond du Lac; Fond du Lac, WI 54935 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1998Volume 129, Issue 9Page: 755KeywordsHealth careLegislation ePublished: 15 August 2000 Issue Published: 1 November 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Reference values of interrupter respiratory resistance in healthy preschool white children
Authors: E Lombardi, P D Sly, G Concutelli, E Novembre, G Veneruso, G Frongia, R Bernardini, A Vierucci
Journal: Thorax (2001)

BACKGROUND Interrupter respiratory resistance (Rint) is reported to be useful in evaluating lung function in poorly collaborating patients. However, no reference values are available from large samples of preschool children using the standard interrupter method. The aim of this study was to define reference Rint values in a population of healthy preschool children. METHODS Rint was assessed without supporting the cheeks in children with no history of wheeze from six kindergartens. To evaluate the effects of upper airway compliance on Rint in healthy children, an additional group of preschool children with either no history of wheeze or no respiratory symptoms at the time of testing underwent Rint measurements in our lung function laboratory with and without supporting the cheeks. Short term (about 1 minute apart) and long term (mean 2.5 months apart) repeatability of Rint measurements (2 SDs of the mean paired difference between measurements) was also assessed in children referred for cough or wheeze. RESULTS A total of 284 healthy white children (age range 3.0–6.4 years) were evaluated. Mean inspiratory and expiratory Rint (Rint i and Rint e ) did not differ significantly in boys and girls. Age, height, and weight showed a significant inverse correlation with both Rint i and Rint e in the univariate analysis with linear regression. Multiple regression with age, height, and weight as the independent variables showed that all three variables were significantly and independently correlated with Rint i , whereas only height was significantly and independently correlated with Rint e . Supporting the cheeks had no significant effect on Rint i (n=29, median 0.673 v 0.660 kPa/l.s, p=0.098) or Rint e (n=39, median 0.702 v 0.713 kPa/l.s, p=0.126). Short term repeatability was 0.202 kPa/l.s for Rint i (n=50) and 0.242 kPa/l.s for Rint e (n=69). Long term repeatability was 0.208 kPa/l.s for Rint e (n=26). CONCLUSIONS We have reported reference Rint values in preschool white children and have demonstrated the usefulness of this technique in assessing lung function in this age group.
Antibiotic prophylaxis in critically ill patients is clinically effective
Journal: BMJ (1998)

Early discharge after surgery for breast cancer may be beneficial Shorter hospital stays are a new trend in surgery.Bonnema et al (p 1267) studied the effects of early discharge from hospital after surgery for breast cancer in a randomised trial of 125 women.Satisfaction with the shorter stay was high, and the duration of drainage from the axilla and the incidence of wound complications did not differ in those who were discharged early and those who remained until their drain was removed.The experience of psychosocial problems was similar in the two groups, as were the coping strategies used.Women who had shorter hospital stays were more likely to discuss their illness with their family.
Detection of common hepatitis C virus subtypes with a third-generation enzyme immunoassa
Authors: K Huber
Journal: Hepatology (1996)

The causal agent of most posttransfusion non-A and non-B hepatitis infections was characterized in 1989 by molecular biological techniques as a positive-stranded, enveloped RNA virus, designated hepatitis C virus (HCV). Only since 1990 has it been possible to screen for an infection with antibody tests or direct amplification assays for the nucleic acid (i.e., reverse-transcription polymerase chain reaction [PCR]). However, these nucleic acid based tests are time consuming and rather expensive. Recently, third-generation enzyme immunoassays (EIAs) for HCV infection were introduced (i.e., Abbott Laboratories, North Chicago, IL; Ortho Diagnostics, Inc., Raritan, NJ; and Roche Diagnostics, Basel, Switzerland). The Roche Diagnostics EIA has been evaluated with our patient population. To this end, 1,090 samples were assayed by both EIA and PCR; 946 of all samples (87%) were negative, and 107 samples (9.8%) were positive by both tests. Thirty of the patients (2.7%) showed antibodies but no detectable virus, whereas 7 of all patients tested (0.6%) were PCR-positive but had not yet developed antibodies to the virus. Of these 7 patients, only one showed normal serum transaminases. Virus strain subtyping and quantification of viral load on the positive samples in parallel have been performed, and the fact that the EIA detects all the virus subtypes found in our hospital can be inferred. No correlation between subtypes, viral load, and immune response could be measured with this antibody test. Our results indicate that, in most circumstances (except in settings where immunocompromised patients are abundant), this EIA can replace the much more expensive PCR tests for the routine screening for HCV infection.
STUDIES ON THE TREATMENT OF HUMAN TRYPANOSOMIASIS WITH TRYPARSAMIDE (THE SODIUM SALT OF N-PHENYLGLYCINEAMIDE-p-ARSONIC ACID)
Authors: Louise Pearce
Journal: The Journal of Experimental Medicine (1922)

On page 1, Supplement No. 1, lines 1 and 2, for November 1, 1921, Vol. xxxiv, No. 5, read December 1, 1921, Vol. xxxiv, No. 6.
Practical Uranalysis and Urinary Diagnosis: A Manual for the Use of Physicians, Surgeons and Students.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
HELIOTHERAPY
Authors: T. M. Allison
Journal: BMJ (1922)

tr w 128g but in each case it is claimed that the doctor shall be on a different footing from the ordinary witness.Two classes of person at present have this special privilegethe lawyer, because without it the courts of law could not function; and the priest, because tthe Church was strong enough to take it.It has been proposed that a similar privilege slhall be granted by Act of Parliament in the case of medical witnesses.On thje othler hand, we are advised by lawyers that such an Act of Parliament would be difficult to obtain and would probably not give us what we want.We are further advised to take our stand when the occasion arises and put it to the judge tllat we do not claim privilege as doctors but that the particular communication in question was made to us in con- fidence and that we cannot, as lhonourable men, disclose it.We are at the same time assured that a judge has as acute a perception of honour as a doctor, and that we shall not be forced to violate our honour.We shiould have more confidence
A JOURNAL OF HEALTH (?).
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Thoracic Park
Authors: Jill Hawkins
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Renal Effects of Environmental and Occupational Lead Exposure
Authors: Mahmoud Loghman-Adham
Journal: Environmental Health Perspectives (1997)

Environmental and industrial lead exposures continue to pose major public health problems in children and in adults. Acute exposure to high concentrations of lead can result in proximal tubular damage with characteristic histologic features and manifested by glycosuria and aminoaciduria. Chronic occupational exposure to lead, or consumption of illicit alcohol adulterated with lead, has also been linked to a high incidence of renal dysfunction, which is characterized by glomerular and tubulointerstitial changes resulting in chronic renal failure, hypertension, hyperuricemia, and gout. A high incidence of nephropathy was reported during the early part of this century from Queensland, Australia, in persons with a history of childhood lead poisoning. No such sequela has been found in studies of three cohorts of lead-poisoned children from the United States. Studies in individuals with low-level lead exposure have shown a correlation between blood lead levels and serum creatinine or creatinine clearance. Chronic low-level exposure to lead is also associated with increased urinary excretion of low molecular weight proteins and lysosomal enzymes. The relationship between renal dysfunction detected by these sensitive tests and the future development of chronic renal disease remains uncertain. Epidemiologic studies have shown an association between blood lead levels and blood pressure, and hypertension is a cardinal feature of lead nephropathy. Evidence for increased body lead burden is a prerequisite for the diagnosis of lead nephropathy. Blood lead levels are a poor indicator of body lead burden and reflect recent exposure. The EDTA lead mobilization test has been used extensively in the past to assess body lead burden. It is now replaced by the less invasive in vivo X-ray fluorescence for determination of bone lead content.
Handbuch der Kinderheilkunde. Ein Buch für den praktischen Arzt.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tumor Enzymology
Authors: Greenstein, Jesse P.
Journal: JNCI Journal of the National Cancer Institute (1943)

Journal Article Tumor Enzymology Get access Jesse P. Greenstein Jesse P. Greenstein senior biochemist National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 3, Issue 4, February 1943, Pages 419–447, https://doi.org/10.1093/jnci/3.4.419 Published: 01 February 1943
Assessing the physical health of homeless adults
Authors: L. Gelberg
Journal: JAMA (1989)

Information on the physical health of homeless adults is potentially biased either by sampling strategy or by measurement of physical health. Studies that used comprehensive health measures (self-reported and objective measures) relied on samples from shelters or hotels. However, more representative community-based studies relied on self-reports or ratings. We conducted the first study to use both a community-based sample (N = 529) and comprehensive measures of health (an interview, a limited physical examination, and blood testing). Shelter dwellers compared with homeless persons sampled elsewhere were less likely to have used illegal drugs, to have been victimized, to have injured skin, and to have elevated aspartate aminotransferase levels and mean corpuscular volumes. Sixty-two percent of persons observed to have high blood pressure were unaware of their condition. Sampling only shelter dwellers, or relying only on reports of illness by homeless adults, may mask or underestimate existent health problems that are revealed by community-based sampling techniques and more objective measures. (<i>JAMA</i>. 1989;262:1973-1979)
"ATHLETIC STRENUOSITY"
Authors: Louis A. Bolling
Journal: JAMA (1925)

<h3>To the Editor:</h3> —Your recent editorial in protest of excessive athletics is timely and heartening. Calling a halt seems to be the order of the day, not limited to athletics but overexercise in general. Reference is made to a recent article in the<i>Saturday Evening</i>Post by that veteran Sam Blythe. In his usual vigorous manner he cautions golf enthusiasts. So, too, I note a quotation from the Indianapolis<i>News</i>on "Rest." As physicians, we must lead in a return to more sane practice in these matters.
The Hirelings
Authors: Fredric L. Coe
Journal: Annals of Internal Medicine (1997)

Ad Libitum1 August 1997The HirelingsFredric L. Coe, MDFredric L. Coe, MDUniversity of Chicago; Chicago, IL 60637Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-127-3-199708010-00013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Our minds are cursed; they hearthe self dismantling beakpick at our stitches, the gearsof its indifferent clocktrack the embracing moist darkwhere mind, beak, clock are unmade,and the moon flooding pools where they were made;those minds, being wise, would escape,from age, disorder, flood,accident and mistake,that break the strongest mould;we were hired foot soldiers,sent against age and chanceto remedy their violence;and the ... Author, Article, and Disclosure InformationAffiliations: University of Chicago; Chicago, IL 60637Corresponding Author: Fredric L. Coe, MD, University of Chicago, Nephrology Section MC 5100, 5841 South Maryland Avenue, Chicago, IL 60637. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1997Volume 127, Issue 3Page: 240-241KeywordsFloodingMemoryStroke ePublished: 15 August 2000 Issue Published: 1 August 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
A randomized phase II study of gemcitabine (G) plus the cardiac glycoside huachansu (H) in the treatment of patients with locally advanced (LAPC) or metastatic pancreatic cancer (MPC).
Authors: Z. Meng, L. Liu, Y. Shen, P. Yang, L. Cohen, Y. Huo, Q. Zhao, C. S. Ng, D. Z. Chang, C. R. Garrett
Journal: Journal of Clinical Oncology (2011)

284 Background: Wild toad venom has been used for over 1,000 years as a traditional Chinese medicine; H, the extract of dried toad skin glands, is a potent cardiac glycoside without significant toxicity. H has demonstrated preliminary evidence of antitumor activity in phase I clinical trial evaluation (Cancer 2009, 115:5309-18). Methods: We conducted a randomized, single-blind, phase II clinical trial of G + H versus G + placebo in patients with LAPC or MPC. Plasma bufalin levels were performed in H-treated subjects. 80 evaluable subjects accrued from October 2007 to May 2010 and were treated with G 1,000mg/m 2 (iv on days 1, 8, 15, q 28d) plus either H (20 mL/m 2 iv daily for 21 days followed by 7 days off, q 28d) or placebo. Demographic data is demonstrated in the table below. Results: Grade 3/4 adverse events, objective radiographic response rates (ORR), time to progression (TTP), quality of life (QOL), and overall survival (OS) were similar in the two groups (Table). There was not a statistically significant difference in the average plasma bufalin levels in patients with a radiographic partial response (PR) or stable disease versus those with progressive disease (PD) (0.098 ± 0.093 ng/mL vs. 0.071 ± 0.048 ng/mL, p=0.679). Conclusions: H when added to G was well tolerated but did not improve OS, TTP, QOL, or ORR. Further investigation of a more potent oral formulation of H is planned. H provided by Shenzhen 999 Traditional Chinese Medicine &amp; Development Co., Ltd. Supported by NIH U19CA121503-01. [Table: see text] No significant financial relationships to disclose.
Catarrhal Child
Authors: J. Fry
Journal: BMJ (1956)

<h3>Objective</h3> First, to investigate the overall efficacy and safety of rituximab (RTX) in refractory granulomatosis with polyangiitis (GPA) in a tertiary referral centre. Second, to compare the efficacy of RTX in granulomatous and vasculitic manifestations in GPA. <h3>Patients and methods</h3> This study comprised a retrospective, standardised data collection from all patients who received RTX for refractory Wegener9s granulomatosis from 2002 to 2010. Patients were assessed by a standardised interdisciplinary diagnostic procedure (including ear, nose and throat and ophthalmology assessment, MRI, immunodiagnostics, B-cell levels and Birmingham Vasculitis Activity Score) and were treated by standardised therapeutic regimens according to available evidence. <h3>Results</h3> 59 patients received 75 cycles of RTX. 9.3% achieved complete remission. A response was documented in 61.3% (improvement in 52%, unchanged disease activity in 9.3%), 26.7% had refractory disease. Birmingham Vasculitis Activity Score, disease extent index, erythrocyte sedimentation rate, C-reactive protein and prednisolone demand decreased significantly. All patients achieved B-cell depletion. Granulomatous manifestations such as orbital granuloma and pachymeningitis were more frequently refractory to RTX than vasculitis or other granulomatous manifestations. Thus, for example, complete remission/improvement was found in 89.2% of patients with renal disease and in only 44.4% of those with orbital masses (p=0.003). The relapse rate was 44.4% after a median period of 13.5 months. Adverse events occurred in 29%, pneumonia in 15% and death in 3%. <h3>Conclusion</h3> The overall response rate of refractory GPA to RTX was high (61.3% complete remission or improvement). Response rates of vasculitic manifestations were excellent; failure of response/progress was mostly due to granulomatous manifestations, especially orbital masses. Relapse rates were high (40%) despite maintenance treatment.