tbuckley/cabot-search huggingface dataset:
Heroin Addicts
Authors: M. M. Glatt
Journal: BMJ (1964)

proliferation of swollen, " epithelium-like " endo- thelial cells in thick layers, often obliterating the lumina (Figs. 2 and 3, X 500; Fig. 4, X 125, which is a detail from Fig. 1).Lesions of this type are known seriously to interfere with the absorptive capacity of the lymphatics, and to provoke fibrosis of the surrounding soft tissues.The blood vessels, however, showed compara- tively insignificant changes.Distally a normal right bundle branch and partially damaged roots of the left were found.Thus the chronic lymphangitis was primarily responsible for the heart block.The extreme rarity of these findings is not, in my opinion, the only reason for interest in the present case.Possibly the atrioventricu- lar node and bundle, which are sometimes very rich in lymph vessels,' might undergo considerable changes up to sclerosis because of prolonged obstruction to drainage of lymph from the heart.Disease of the cardiac lymph-vessels might therefore explain some of the hitherto ill-understood lesions of the conducting system.-Iam, etc.,
A Farewell
Authors: Marcia Angell
Journal: New England Journal of Medicine (2000)

At the end of this month, I will be leaving the Journal after 21 years as an editor. I began in 1979 as assistant deputy editor, became executive editor in 1988, and became editor-in-chief last year. It has been an extraordinary experience.I have had the opportunity to witness from a front-row seat the unfolding of some of the most spectacular advances in medicine and to shape the recording of many of them. I have seen the system for financing and delivering medical care undergo a series of cataclysmic upheavals and realignments, many of which were played out in the . . .
Hemolytic Activity of Five Different Calcium Silicates
Authors: Vidar Skaug, Bjorn Gylseth
Journal: Environmental Health Perspectives (1983)

Mineral characteristics and the in vitro hemolytic activity of three synthetic and two natural calcium silicates (CaSi) are compared. Hemolysis is higher for the synthetic compounds than for the natural ones. The difference is accentuated by weak ultrasonication of the minerals. No variation was observed within the two groups, including both acicular and fibrous forms. Calcium was released from the minerals during storage in Tris-buffered saline. At the same time, hemolysis decreased, and crystallographic alterations occurred in the leached minerals. Treatment of the CaSi with calcium chelators (EGTA and EDTA) did not change hemolytic activity. An increase was observed when 30 mM calcium was added. Hemolysis is related to specific surface areas and the crystalline structure of the minerals. Calcium may also be a contributing factor.
Society Proceedings
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reply:
Authors: Anna Wieckowska, Arthur J. McCullough, Ariel E. Feldstein
Journal: Hepatology (2007)

We appreciate the interest of Dr. Dhawan and his colleagues in our recent articles regarding caspase-generated cytokeratin-18 (CK-18) fragments as a novel biomarker for nonalcoholic fatty liver disease (NAFLD).1, 2 We also welcome their results assessing the value of serum CK-18 fragment levels in pediatric NAFLD. The results of this study are consistent with our previous studies in adult patients showing that blood CK-18 fragment levels are increased in patients with nonalcoholic steatohepatitis (NASH) and positively correlate with disease severity. The CK-18 test has several unique features that fulfill many of the requirement for an ideal biomarker for NAFLD, including the fact that the test is simple, easy to measure and handle, and reproducible and identifies not only the presence of NASH but also the risk of associated fibrosis.3 It now appears to have another key feature of a biomarker that is lacking in most other noninvasive tools for either fibrosis or NASH diagnosis under investigation, that is, prospective independent validation in a different population and laboratory. We do agree that future larger cross-sectional studies are still needed to better assess the role of this marker in children as well as longitudinal studies in both adult and children to determine the clinical utility for monitoring disease status and response to therapy over time. Anna Wieckowska*, Arthur J. McCullough*, Ariel E. Feldstein , * Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, OH, Department of Pediatric Gastroenterology, Cleveland Clinic, Cleveland, OH, Department of Cell Biology, Cleveland Clinic, Cleveland, OH.
SETTING ONE'S COURSE
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
LETTER FROM NEW YORK.
Authors: None P. B. P.
Journal: JAMA (1891)

(FROM OUR OWN CORRESPONDENT.) An official record of the four executions by electricity at Sing Sing prison on July 7th, has now been published, and it fully confirms the correctness of the first newspaper reports as to the admirable manner in which they are conducted and the instantaneousness and painlessness with which death was in each instance produced. In accordance with the provisions of the new statute the warden of Sing Sing has sent to the county clerk formal certificates of the four executions accompanied by a report of the observations of Dr. Carlos F. MacDonald, President of the State Commission on Lunacy, and Dr. Samuel B. Ward, of Albany, who served as the official physicians at the executions. In their report the physicians state that all of the condemned walked into the execution-room unaided, with firmness, and without assistance, quietly seated themselves in the electric chair and submitted without
Chronic Toxic Encephalopathy in a Painter Exposed to Mixed Solvents
Authors: Robert G. Feldman, Marcia Hillary Ratner, Thomas Ptak
Journal: Environmental Health Perspectives (1999)

This paper describes symptoms and findings in a 57-year-old painter who had been exposed to various organic solvents for over 30 years. He began to work as a painter at 16 years of age, frequently working in poorly ventilated areas; he used solvents to remove paint from the skin of his arms and hands at the end of each work shift. The patient and his family noticed impaired short-term memory function and changes in affect in his early forties, which progressed until after he stopped working and was thus no longer exposed to paints and solvents. After the patient's exposures had ended, serial neuropsychological testing revealed persistent cognitive deficits without evidence of further progression, and improvement in some domains. Magnetic resonance imaging revealed global and symmetrical volume loss, involving more white than gray matter. The findings in this patient are consistent with chronic toxic encephalopathy and are differentiated from other dementing processes such as Alzheimer's disease, multi-infarct (vascular) dementia, and alcoholic dementia. Previous descriptions in the literature of persistent neurobehavioral effects associated with chronic exposure to organic solvents corroborate the findings in this case.
Hyaluronan Receptor LYVE-1-Expressing Macrophages Maintain Arterial Tone through Hyaluronan-Mediated Regulation of Smooth Muscle Cell Collagen
Authors: Hwee Ying Lim, Sheau Yng Lim, Chek Kun Tan, Chung Hwee Thiam, Chi Ching Goh, Daniel Carbajo, Samantha Hui Shang Chew, Peter See, Svetoslav Chakarov, Xiao Nong Wang, Li Hui Lim, Louise A. Johnson, Josephine Lum, Chui Yee Fong, Ariff Bongso, Arijit Biswas, Chern Goh, Maximilien Evrard, Kim Pin Yeo, Ranu Basu, Jun Kit Wang, Yingrou Tan, Rohit Jain, Shweta Tikoo, Cleo Choong, Wolfgang Weninger, Michael Poidinger, E. Richard Stanley, Matthew Collin, Nguan Soon Tan, Lai Guan Ng, David G. Jackson, Florent Ginhoux, Véronique Angeli
Journal: Immunity (2018)
Blastomycosis in Arkansas
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Polymyositis and toxoplasmosis
Authors: B. S. Samuels
Journal: JAMA (1976)

ALTHOUGH Kagen et al<sup>1</sup>suggest a causal relationship between polymyositis and toxoplasmosis, only two of their ten patients had sequential antibody studies when treated with pyrimethamine and sulfonamides, both of whom showed some fall in antibody titers. Our report involves a patient with classical polymyositis that improved after a diagnosis of toxoplasmosis was established and the disease treated. Improvement coincided with the fall of<i>Toxoplasma</i>titers on three separate occasions. <h3>Report of a Case</h3> A 49-year-old woman noted aching in and discoloration of her hands, dysphagia, and then weakness of her shoulder and pelvic girdles. Subsequently, intermittent swelling of the periorbital regions developed, along with mild arthralgias, slight swelling of the fingers, and an erythematous leg discoloration accentuated by prolonged standing. The shoulder girdle was tender and the shoulder and pelvic girdle musculature was considerably weak, particularly in the neck extensors and hip abductors. Telangiectasia was present over the anterior
&lt;emph type="ital"&gt;ABCA1&lt;/emph&gt; Gene Mutations, HDL Cholesterol Levels, and Risk of Ischemic Heart Disease—Reply
Authors: Anne Tybjærg-Hansen
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Calling
Authors: Abraham Verghese
Journal: New England Journal of Medicine (2005)

I grew up in Africa, the younger of two sons of Indian parents who taught college physics. Around the time that my brother's precocious ability with numbers was revealing itself, I discovered that I had no head for math — or for any other subject in the school curriculum.Middle-class Indian parents worshipped the professions, and only three existed for them: medicine, engineering, and law. When my brother announced, while still in short pants, that he was going to be an engineer, my parents' joy was astonishing to behold. Nothing I had ever said had produced such a reaction. I . . .
Abstract 20949: Impact of Renal Denervation on Autonomic Nerve Activity
Authors: Youngjin Cho, Eue-Keun Choi, Il-Young Oh, Myung-Jin Cha, Seil Oh
Journal: Circulation (2017)

Introduction: Recent studies reported potential antiarrhythmic effect of catheter-based renal denervation (RDN). We sought to evaluate impacts of RDN on cardiac autonomic nerve activity in ambulatory canine model. Methods: Telemetry devices (D70-EEE, DSI) were implanted in 17 mongrel dogs to record ambulatory nerve activity simultaneously from left stellate ganglion (SG), superior left ganglionated plexus (SLGP), and left renal nerve. After 1 week of baseline nerve activity recording, RDN was performed at both renal arteries using a specialized catheter (Symplicity TM , Medtronic) (n=10). A control animals underwent autonomic nerve recording operation but with sham procedure (n=3). Bilateral surgical stripping of the renal nerve adventitia was performed in 4 dogs (n=4, surgical RDN). One-minute integrated nerve activities were quantified and compared among groups up to 2 weeks. Results: Renal nerve acvitivity (RNA) decreased after catheter RDN (-6.7±13.4% from baseline), while RNA increased after sham operation by 7.4±9.5% (p=0.103). After surgical RDN, no RNA was observed. In contrast to the increased SG nerve activity (SGNA) after sham operation (+2.2±11.4%), SGNA decreased after catheter RDN (-2.1±10.8%, p=0.073) and surgical RDN (-10.6±13.1%, p=0.061 vs. control). SLGP nerve activity (SLGPNA) also increased by 7.1±3.1% after sham operation, while SLGPNA decreased after catheter-based (-8.1±13.9%, p=0.008), and surgical RDN (-6.3±10.2%, p=0.073 vs. control). Immunohistochemistry showed increment of TH (tyrosine hydroxylase)-negative cells in SG after RDN (% of TH-negative cells: control=1.8%, catheter RDN=5.5% [p=0.058 vs. control], surgical RDN=7.35% [p=0.039, vs. control]). Conclusions: The response of renal nerve and cardiac autonomic nerve activity to catheter based RDN was diverse. Renal denervation decreased SGNA and SLGPNA, with neural remodeling at SG. These results may support anti-arrhythmic effects of RDN.
Recent Events of Special Interest to Medical Education
Authors: C. H. William Ruhe
Journal: JAMA (1980)

For the 15th consecutive year Section I of the EDUCATION ISSUE is devoted to "Recent Events of Special Interest to Medical Education." Information has been included about special studies, reports, legislation, and other events and activities that are related to medical education and may be expected to influence its future course and direction. The most significant development during the past year has been the reconsideration and redesign of the structure and function of the various liaison committees responsible for the accreditation of medical education. Since last year's report, a new spirit of reconciliation and accommodation has prevailed among the major organizations responsible for the control and direction of medical education. At the time this report was prepared, negotiations were in progress to redefine the separate roles of the liaison committees and their relationship to each other. Fiscal restraint continues to be the most predominant factor influencing the educational programs of
Corrections
Journal: JNCI Journal of the National Cancer Institute (1980)

In “Breast Cancer Risk From Low-Dose Exposures to Ionizing Radiation: Results of Parallel Analysis of Three Exposed Populations of Women”by Charles E. Land, John D. Boice, Jr., Roy E. Shore, James E. Norman, and M. Tokunaga, tables 2 and 3 on page 357 show estimates and standard errors for the coefficient α2 of the square of gamma dose that are too large by a factor of 10. Thus in table 2, second column, last row, the estimate for α2 should be 0.00515±0.00214 rather than 0.0515±0.0214. In table 3 the estimates for α2 should read as follows under each encompassing centered heading: Open in new tabDownload slide
The High Price of Problem Drinking
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Thermodilution Cardiac Output Measurement
Authors: John H. Stevens
Journal: JAMA (1985)

Thermodilution cardiac output measurements are commonly employed in the management of critically ill patients. Serial measurements often show significant variation, and poor reproducibility limits their clinical utility. There are no clinical studies revealing when to perform thermodilution cardiac output measurements in relation to the respiratory cycle. We prospectively studied 32 patients in a randomized scheme comparing three thermodilution cardiac output measurements at peak-inspiration, at end-exhalation, or randomly in spontaneously breathing and mechanically ventilated patients. Saline injections initiated at peak-inspiration or end-exhalation resulted in cardiac output measurements with much smaller standard deviations than those seen with random injections. Thermodilution cardiac output measurements performed at random times in the respiratory cycle should be avoided, and we recommend initiating these measurements at end-exhalation. (<i>JAMA</i>1985;253:2240-2242)
Editorial: The Future of Environmental Medicine in Environmental Health Perspectives: Where Should We Be Headed?
Authors: Brian S. Schwartz, Gary Rischitelli, Howard Hu
Journal: Environmental Health Perspectives (2005)

In 1998, Environmental Health Perspectives (EHP) began "Grand Rounds in Environmental Medicine" as a regular feature (Hu 1998;Hu and Woolf 2003).This soon led to an expanded Environmental Medicine section that aimed to regularly publish articles in the Grand Rounds format as well as reviews, commentaries, case reports, and research articles, all of relevance to environmental medicine, with a focus mainly on clinical practice
Myasthenia gravis syndrome associated with trimethadione
Authors: H. E. Booker
Journal: JAMA (1970)

A myasthenic reaction in an 8-year-old girl developed within a few months during treatment of petit mal seizures with trimethadione. Progressive bulbar weakness culminated in a crisis with respiratory failure following a major convulsion. Initially, large doses of neostigmine (Prostigmin) methylsulfate were required, but a complete remission occurred within six months after trimethadione was withdrawn. This case is remarkably similar to the case described by Peterson,<sup>1</sup>and supports his hypothesis that an auto-immune response to trimethadione was the responsible mechanism.
Modifying chickenpox.
Authors: E Pennington, S Pennington
Journal: BMJ (1991)

sleeping occupants of the bedroom.Its capacity to resist starvation is legendary, but it has few other outstanding qualities (apart from one of the most peculiar methods of copulation in the insect world)... but I digress.Someone at least appreciated its dogged determination to seek out its host when writing the following:The butterfly has wings of gold,The firefly wings of flame;The bed bug has no wings at all, But he gets there just the same."2 1 Mellanby K.The transmission of scabies.
Best in class hepatitis B virus anti-sense oligonucleotides: next generation bridged nucleic acid chemistries significantly improve the therapeutic index by reducing hepatotoxicity and increasing in vivo efficacy in a mouse model
Authors: Jin Hong, Rajendra Pandey, Vivek Rajwanshi, Dinah Misner, Hua Tan, John Cortez, Yuchun Nie, Suping Ren, Dana Cho, Laxman Eltepu, Tilani De Costa, Priya Mishra, Kang Hyunsoon, Aneerban Bhattacharya, Sushmita Chanda, David Smith, Julian Symons, Lawrence Blatt, Leonid Beigelman
Journal: Journal of Hepatology (2020)
TUBERCULOUS IMMIGRANTS.
Journal: BMJ (1965)

have wisely reminded us that before we design a new constitution for the B.M.A. we should do some deep think- ing on what the Association's purpose should be.Well, here are some thoughts.Much of our trouble derives from the fact that since 1948, if not since 1911, we have allowed our- selves to become a nearly indispensable branch of the Government's administrative machine, and have appeared positively to welcome it, and this has hung upon us like the albatross.Professor Eckstein (1960), in his book Pressure Group Politics, wrote that if in 1948 the B.M.A. had not existed the Government would have had to invent it.We should aim to disengage ourselves from this invidious position.