tbuckley/cabot-search huggingface dataset:
Book Review Current Therapy of Trauma and Surgical Critical Care (Current Therapy.) Edited by Juan A. Asensio and Donald D. Trunkey. 785 pp., illustrated. Philadelphia, Mosby, 2008. $139. 978-0-323-04418-9 Trauma: Contemporary Principles and Therapy Edited by Lewis Flint, J. Wayne Meredith, C. William Schwab, Donald D. Trunkey, Loring W. Rue, and Paul A. Taheri. 784 pp., illustrated. Philadelphia, Lippincott Williams &amp; Wilkins, 2008. $199. 978-0-7817-5650-1
Authors: Danny O. Jacobs
Journal: New England Journal of Medicine (2008)
Abstract 3965: Circulating levels of IFN gammaand neutrophil counts in breast cancer patients who received balixafortide and eribulin combination therapy
Authors: Johann Zimmermann, Garry Douglas, Barbara Romagnoli, Debra Barker, Daniel Obrecht
Journal: Cancer Research (2019)

Abstract Background: Balixafortide (B) is a highly selective antagonist of the chemokine receptor CXCR4. Clinical proof-of-concept in combination with eribulin (E) was achieved in a recent Phase 1 single arm dose-escalation trial in patients with metastatic HER2-negative breast cancer (NCT01837095). Safety and tolerability of B in combination with E was similar to that of B or E monotherapy. Anti-cancer effects of CXCR4 antagonists include sensitization of tumor cells to chemotherapy, suppression of metastatic spread, inhibition of angiogenesis, and activation of immune cells. Methods: Plasma samples from patients who received initial E monotherapy (1.4 mg/m2, run-in cycle) or combination of B and E (escalating doses of B intravenous up to 5.5 mg/kg plus E 1.4 mg/m2 in 21 days cycles) were immediately processed and stored at -80°C. Circulating levels of IFN-γ, an important marker of anti-tumor immune response, were determined by a high-sensitive S-Plex assay (Meso Scale Diagnostics). Absolute neutrophil counts (ANC) were measured by automated hematology instruments. Results: E monotherapy did not increase IFN-γ levels in the first 8 hours post dosing, but led to an increase after 24 hours. Combination with B modulated IFN-γ levels and led to a sustained ANC increase 5 days post dosing. The increase pre vs post treatment can be up to 100-fold and receded prior to the next treatment cycle. Conclusions: E treatment led to a strong, transient increase of plasma IFN-γ levels in breast cancer patients modulated by B. The ANC increase by B may balance possible neutropenic actions of E. Citation Format: Johann Zimmermann, Garry Douglas, Barbara Romagnoli, Debra Barker, Daniel Obrecht. Circulating levels of IFN gammaand neutrophil counts in breast cancer patients who received balixafortide and eribulin combination therapy [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3965.
Physical Diagnosis: A Physiologic Approach.
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Erratum: A mouse model of human familial hypercholesterolemia: Markedly elevated low density lipoprotein cholesterol levels and severe atherosclerosis on a low-fat chow diet
Authors: Lyn Powell–Braxton, Murielle Véniant, Richard D. Latvala, Ken-Ichi Hirano, Wesley B. Won, Jed Ross, Noel Dybdal, Constance H. Zlot, Stephen G. Young, Nicholas O. Davidson
Journal: Nature Medicine (1998)
From the Centers for Disease Control. HIV prevention in US correctional system, 1991
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Book Review The Retina: The anatomy and the histology of the retina in man, ape and monkey, including the consideration of visual functions, the history of physiological optics and the histological laboratory technique . By S. L. Polyak, M.D. A fiftieth-anniversary publication of the University of Chicago Press. 4°, cloth, 729 pp., with 100 illustrations. Chicago: The University of Chicago Press, 1941. $10.00.
Journal: New England Journal of Medicine (1942)
New Tuberculosis Test Approved
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bacteriophage therapy in infective childhood asthma
Authors: H. J. Wittig
Journal: JAMA (1966)

A majority of cases of asthma encountered in the first decade of life can be classified as "infective asthma."<sup>1</sup>This condition is characterized by association of asthmatic attacks with episodes of infection and by lack of demonstrable allergic etiology. Most conventional therapeutic approaches to the problem of prevention of such attacks have been disappointing in their results. In 1963, Baker,<sup>2</sup>as well as Salmon and Symonds,<sup>3</sup>had claimed beneficial effects on chronic childhood asthma from injections with staphylococcus bacteriophage lysate vaccine (staphage lysate). This material is produced from broth cultures of virulent strains of coagulase-positive<i>Staphylococcus aureus</i>, serologic types I and III, which have been lysed by a bacteriophage. <h3>Material and Methods</h3> Forty-four children with "infective asthma," who had been followed for at least one year prior to study in the Outpatient Department of Jersey City Medical Center and who had shown definite association of asthma with
Pulmonary function and complications following chemotherapy and stem cell support in breast cancer
Authors: F. Fanfulla, P. Pedrazzoli, G.A. Da Prada, C. Bruschi, E. Dacosto, A. Zambelli, G.R. della Cuna, C. Rampulla
Journal: European Respiratory Journal (2000)

Pulmonary complications are frequent in patients treated with high-dose chemotherapy and autologous bone marrow transplantation for breast cancer or other solid tumours. This study analyses the development of lung toxicity, changes in respiratory function and occurrence of clinical symptoms in a group of 24 patients (mean age 46+/-7 yrs) who underwent high-dose sequential chemotherapy (HDS) with autologous peripheral blood stem cell (PBSC) support for high risk breast cancer. Clinical examination, chest radiography and lung function tests were performed before the HDS and 1 and 3 months following transplantation. Only one patient developed acute interstitial pulmonary disease which resolved after prednisone therapy. No patients developed infectious complications after transplantation. Baseline respiratory function was normal for most of the parameters. Only lung diffusing capacity of the lung for carbon monoxide (TL,CO) and maximal inspiratory pressure were below the normal range. Following PBSC transplantation only one patient had an altered vital capacity while 72.3% of patients had reduced TL,CO values at 1 month and 54.5% at 3 months after transplantation. Maximal expiratory flow at 25% forced vital capacity, TL,CO and maximal expiratory pres-sure were significantly reduced after 1 month but recovered slightly by 3 months. Arterial oxygen tension between baseline and both follow-up evaluations declined significantly in patients seropositive for human cytomegalovirus. It is concluded that this high-dose sequential chemotherapy regimen is acceptably safe since no pulmonary related mortality or respiratory infectious complications were observed. The only lung function alteration induced was an isolated diffusing capacity of the lung for carbon monoxide impairment, clinically negligible and partially recovered within 3 months.
Community responsibility for stabilizing trauma systems
Authors: R. J. Anderson
Journal: JAMA (1997)

<h3>In Reply.</h3> —Our analysis evaluated the likelihood that current national control policies would reach previously set goals for the elimination of TB in the United States. Evaluation of control policies in particular risk groups, such as health workers, is a logical next step, but it was not the purpose of the current study. The scenario<sup>1</sup>described by Drs Reichman and Mangura has been published as a letter to the editor in reference to earlier work<sup>2</sup>done by some of us. In our view, while BCG vaccination complicates surveillance, it does not preclude it. We believe BCG would be effective in preventing TB among health care workers, as discussed more fully in this earlier work<sup>2</sup>and correspondence.<sup>3</sup>Several decision analyses by others<sup>4,5</sup>have similarly concluded that BCG vaccination is a reasonable option for TB prevention among health care workers. Although important, the ability to undertake future surveillance is
Euthanasia as a Romantic Motive.
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
This Week in <emph>JAMA</emph>
Journal: JAMA (2008)

A Piece of My Mind"Should I mar the identity of this complex person with such a rich life and legacy by reducing her to a medical diagnosis at the end-when, really, it was just genug?"From "Genug Syndrome." SEE PAGE 2606 Medical News & PerspectivesAging in America is explored in articles on how the US health care system is ill prepared to deliver geriatric care to an aging population, on projections that emergency departments may be strained by increasing numbers of visits by older adults, and on programs that are tackling the challenge of bringing physician-based care to homebound seniors.
TMIC-09. TOWARDS A FRAMEWORK FOR PREDICTIVE MATHEMATICAL MODELING OF THE BIOMECHANICAL FORCES CAUSING BRAIN TUMOR MASS-EFFECT
Authors: Daniel Abler, Russell Rockne, Philippe Büchler
Journal: Neuro-Oncology (2017)

GBMs present with different growth phenotypes, ranging from invasive lesions without notable mass-effect to strongly displacing lesions that induce mechanical stresses and result in healthy-tissue deformation, midline shift or herniation. Biomechanical forces, such as those resulting from displacive tumor growth, are recognized to shape the tumor environment and to contribute to tumor progression. We therefore expect that biomechanical forces exerted by lesions on the brain parenchyma have implications on the biophysical level, and that they may affect treatment response and outcome. To better understand the role of biomechanics in the formation of different GBM phenotypes we started developing a framework for the predictive mathematical modeling of mechanical tumor-healthy tissue interaction on the macroscopic level. The tumor’s mass-effect is represented by a solid-mechanics model of brain tissue that computes tumor-induced strain based on local tumor cell concentration. The framework allows to seed tumors at multiple locations in a human brain atlas. It simulates tumor evolution over time and across different brain regions using literature-based parameter estimates for tumor cell proliferation, as well as isotropic motility, and mechanical tissue properties. Despite its simplicity, the mathematical model yielded realistic estimates of the mechanical impact of a growing tumor on intra-cranial pressure. However, comparison to publicly available GBM imaging data showed that asymmetric shapes could not be reproduced by isotropic growth assumptions. Here we present and evaluate an extended version of this mechanically-coupled reaction-diffusion model that takes into account tissue anisotropies based on MRI diffusion tensor imaging (MR-DTI). Structural anisotropies in brain tissue have been found to affect the directionality of tumor cell migration and are critical to mechanical behavior. This makes them likely to play a role also in the development of GBM phenotypes.
Editorial: Disappearance of streetcars. Was spitting responsible?
Authors: H. H. Hussey
Journal: JAMA (1975)

The special feature, "JAMA 75 Years Ago," has its devotees who read it with amusement when they note the foibles of our predecessors in medical practice, or with chagrin when they find that medical affairs have not improved much with the passage of time. The item in the Oct 20, 1975, issue of<i>JAMA</i>(p 294) was concerned with the need for control of the filthy habit of spitting in public places. The author, Elmer B. Borland, MD, observed in passing that Dickens characterized Americans as a nation of spitters, lacking the natural instinct of cleanliness. Borland continued: Five years ago, the writer read a paper before the Allegheny County Medical Society recommending restriction and regulation of the spitting habit. Nine of ten members who took part in the discussion agreed that restriction and regulation were needed. Six, however, of the nine thought any regulation impossible. "Women can, but men
4-hydroxynonenal levels are enhanced in fetal liver mitochondria by in utero ethanol exposure
Authors: J Chen
Journal: Hepatology (1997)

Lipid peroxidation has been implicated in ethanol-induced liver injury and observed in fetal liver and brain after maternal ethanol consumption with mitochondria being the target organelles. This process generates a highly reactive and toxic product, 4-hydroxynonenal (HNE). In the present study, HNE levels and metabolism were assessed in mitochondria of fetal and maternal liver after in vivo ethanol exposure. Female Sprague-Dawley rats received five doses of ethanol (4 g/kg orally at 12-hour intervals) and were killed on day 19 of gestation. The results showed that HNE levels were enhanced in hepatic mitochondria of fetal rats exposed to ethanol, far in excess of that in adult liver mitochondria. Measurement of HNE metabolism showed that fetal mitochondria had a lower capacity for HNE catabolism than adult mitochondria. In adult mitochondria, HNE could be metabolized by nicotine adenine dinucleotide-dependent oxidation, reduced glutathione conjugation, and reduced nicotine adenine dinucleotide-dependent reduction, whereas in fetal liver only the former two pathways were active, but to a lesser degree than in adult mitochondria. On the other hand, mitochondria from fetal liver showed a higher production of HNE when oxidative stress was induced with t-butyl hydroperoxide. Prior in vivo ethanol exposure further potentiated HNE formation in t-butyl hydroperoxide-stimulated fetal liver mitochondria, but not in adult mitochondria. These findings indicate that increased levels of HNE in fetal liver mitochondria after maternal ethanol consumption reflect a higher susceptibility to HNE formation in addition to a lesser capacity to metabolize it. The enhanced accumulation of this toxic aldehyde may contribute to oxidative damage observed in fetal tissues after in utero ethanol exposure. (Hepatology 1997 Jan;25(1):142-7)
METABOLISM AT DIFFERENT AGES
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CANCER OF THE RECTUM
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Human in vitro fertilization
Authors: H. G. Bramm
Journal: JAMA (1982)

<h3>In Reply.—</h3> The argument of possible risk is central for the ethics of in vitro fertilization. The low success rate of implantations and the high rate of spontaneous abortions, compared with natural pregnancies, are causes for worry. Comparing children born by this method with those conceived traditionally cannot be scientifically done for some time, according to cited statistical rules. More important, this procedure experiments with future lives, and there is no way of proving it safe without such experimental risk. I argue that risk should be undertaken only for oneself or when it is unavoidable for helping human beings. We should not conceive when there is an increased chance for harm. It is true that parents have ample reason for feeling guilty. But why add to those reasons? The evidence here lies in considering oneself in place of parents with seriously ill children who were technologically conceived. If exposure to
Translucent Transparency
Authors: Mike Mitka
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal