tbuckley/cabot-search huggingface dataset:
The Cover
Authors: Marilyn Heins
Journal: JAMA (1981)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Flipping the model for access to patient records
Journal: BMJ (2016)

Flipping the model for access to patient records NHS England would like to make it clear that care.data is a separate project to the online GP records programme.The online GP records system is an ongoing process with a defined end date of completion (2018) that will allow patients online access to their medical records from their GP practice.This programme is not running under the care.dataremit, which will be storing medical data from NHS patients on a central database managed by HSCIC and using this as a real world data tool.
Peginterferon Alfa-2a and Ribavirin for 16 or 24 Weeks in HCV Genotype 2 or 3
Authors: Mitchell L. Shiffman, Fredy Suter, Bruce R. Bacon, David Nelson, Hugh Harley, Ricard Solá, Stephen D. Shafran, Karl Barange, Amy Lin, Ash Soman, Stefan Zeuzem
Journal: New England Journal of Medicine (2007)

Patients infected with hepatitis C virus (HCV) genotype 2 or 3 have sustained virologic response rates of approximately 80% after receiving treatment with peginterferon and ribavirin for 24 weeks. We conducted a large, randomized, multinational, noninferiority trial to determine whether similar efficacy could be achieved with only 16 weeks of treatment with peginterferon alfa-2a and ribavirin.We randomly assigned 1469 patients with HCV genotype 2 or 3 to receive 180 mug of peginterferon alfa-2a weekly, plus 800 mg of ribavirin daily, for either 16 or 24 weeks. A sustained virologic response was defined as an undetectable serum HCV RNA level (<50 IU per milliliter) 24 weeks after the end of treatment.The study failed to demonstrate that the 16-week regimen was noninferior to the 24-week regimen. The sustained virologic response rate was significantly lower in patients treated for 16 weeks than in patients treated for 24 weeks (62% vs. 70%; odds ratio for 16 weeks vs. 24 weeks, 0.67; 95% confidence interval, 0.54 to 0.84; P<0.001). In addition, the rate of relapse (a detectable HCV RNA level during follow-up in patients who had undetectable HCV RNA at the end of treatment) was significantly greater in the 16-week group (31%, vs. 18% in the 24-week group; P<0.001). The sustained virologic response rates in patients with a pretreatment serum HCV RNA level of 400,000 IU per milliliter or less was 82% with the 16-week regimen and 81% with the 24-week regimen. Among patients with a rapid virologic response (an undetectable HCV RNA level by week 4), sustained virologic response rates were 79% in the 16-week group and 85% in the 24-week group (P=0.02).Treatment with peginterferon and ribavirin for 16 weeks in patients infected with HCV genotype 2 or 3 results in a lower overall sustained virologic response rate than treatment with the standard 24-week regimen. (ClinicalTrials.gov number, NCT00077636 [ClinicalTrials.gov].).
Electrocardiographic Analysis by a Computer System
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A MEDICAL MISSIONARY SCHOLARSHIP IN LONDON. SURGEONS IN GREAT DEMAND.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Childhood diabetes and intensive insulin therapy
Authors: E. C. Baptist
Journal: JAMA (1983)

<h3>In Reply.—</h3> Dr Baptist's letter interprets our report to indicate that multiple insulin injections are mandatory for good glycemic control. In fact, this is not necessarily implied. What is mandatory is that good control be achieved, and, as we indicated, in most patients this requires multiple injections. The group of patients in whom this may not be necessary, as implied by Dr Baptist, may be "protected" early in the course of their diabetes, when endogenous insulin secretion may still contribute to modulation of control. However, in our experience and that of others,<sup>1</sup>the vast majority of patients do not fall into this group. We would also prefer not to leave the reader with the idea that multiple insulin injections, as opposed to one, are necessarily more traumatic to parent or child. Depending on how the initial experience is handled, the number of injections usually is not a problem. Conversely,
Allergy Testing
Authors: American College of Physicians
Journal: Annals of Internal Medicine (1989)

Position Paper15 February 1989Allergy TestingAmerican College of PhysiciansAmerican College of PhysiciansSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-110-4-317 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe identification of those allergenic substances that may be responsible for producing or aggravating diseases such as asthma, allergic rhinitis, eczema, urticaria, anaphylaxis, and gastrointestinal reactions is frequently important for effective patient care. Most allergens trigger symptoms by reacting with specific IgE antibodies on mast cells and basophils in target tissues, resulting in the release of potent vascular and smooth muscle-reacting mediators such as histamine and leukotrienes, and generation of inflammation with infiltration by lymphocytes and eosinophils.Sometimes the allergen responsible for an allergic reaction is obvious from the patient's history. If not, testing may be advisable to identify the... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *This paper was authored by Paul VanArsdel, Jr., MD; and Eric B. Larson, MD, MPH; and was developed for the Health and Public Policy Committee by the Clinical Efficacy Assessment Subcommittee: Paul F. Griner, MD, Chairman; Charles C. Smith, Jr., MD; Paul Calabresi, MD; Lockhart B. McGuire, MD; Earl P. Steinberg, MD; Harold J. Sox, Jr., MD. Members of the Health and Public Policy Committee were: Richard G. Farmer, MD, Chairman; Michael A. Nevins, MD; Charles E. Lewis, MD; Joseph E. Johnson III, MD; Paul F. Griner, MD; John M. Eisenberg, MD; F. Daniel Duffy, MD; Donald L. Feinstein, MD; C. S. Lewis, Jr., MD; Steven A. Schroeder, MD; Quentin D. Young, MD. This paper was approved by the Board of Regents on 29 February 1988. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byUnconventional Theories and Unproven Methods in AllergyAllergic RhinitisUnconventional Theories and Unproven Methods in AllergyDiagnostic Evaluation of Inhalant Allergies: A Cost-effectiveness AnalysisInsulin AllergyEPIDEMIOLOGIC CONSIDERATIONS IN OCCUPATIONAL ASTHMATECHNIQUES USED IN ASSESSING AND MONITORING DISEASE SEVERITY AND PROGRESSIONTesting for Allergic DiseaseSteven J. Smith, PhD, William R. Hendee, PhD 15 February 1989Volume 110, Issue 4Page: 317-320KeywordsAllergensAllergic diseasesAllergic rhinitisAllergy and immunologyMuscular dystrophiesPrevention, policy, and public healthPublic policySafetySub-specialty careUrticaria ePublished: 1 December 2008 Issue Published: 15 February 1989 PDF downloadLoading ...
Tuberculin Reaction Associated with Tuberculous Infection
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Topical ether and herpes simplex labialis
Authors: M. E. Guinan
Journal: JAMA (1980)

In a double-blind, placebo-controlled study, 51 patients with recurrent herpes simplex labialis were treated with topical ether or placebo within 24 hours of onset of a lesion. There was no noteworthy difference between groups given ether and placebo in progression of lesions, healing time, duration or intensity of pain, and duration or quantity of virus excretion. The ether also failed to reduce appreciably lesion virus titer, even when lesions were cultured immediately after topical application. Despite these results, 75% of the patients receiving ether and 77% of those receiving placebo reported effective reduction of the severity and duration of lesions. The marked placebo effect in the treatment of recurrent herpes infection helps to emphasize the need for objective measurements and placebo-controlled studies. (<i>JAMA</i>243:1059-1061, 1980)
Editor's Choice
Journal: BMJ (2005)

ConclusionBlood pressure can be controlled to the same degree with either practice based self monitoring or usual care.Self monitoring of blood pressure results in worthwhile improvements in systolic blood pressure at six months.How this early improvement might be maintained requires further study.Self monitoring has negligible costs, reduces practice consulting rates, and is acceptable to patients.If the training associated with self monitoring were performed by non-medical or lay individuals then cost savings might be possible.
JAMA 75 YEARS AGO
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Penicillin-induced haemolytic anaemia.
Journal: BMJ (1968)

MEDBRITIRH 4 6July 198Laig ArilsMEDICAL JOURNAL in cows with hypocalcaemia and hypophosphataemia at parturition showed that excess release of calcitonin might be responsible for their condition."9The role of calcitonin in clinical therapeutics has yet to be fully defined.Several investigators have shown that when injected it lowers the serum calcium in patients with hypercalcaemia of widely differing aetiology.9 11 12 20-22A patient
BERLIN
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Stress and relapse of breast cancer: Authors' reply
Authors: A. J Ramirez, T K Craig, J P Watson, I. S Fentiman, M. Richards, W R S North, R D Rubens
Journal: BMJ (1989)

necessary.My experience of local hospital teams is that it is difficult to be placed in a disaster environment when you are used to working in a gynaecological operating theatre.As Dr Nancekievill says, major accidents occur when least expected, and the best plan is to have available staff who are used to dealing with smaller incidents, are readily available and know the area, and can be on site through the ambulance control centre at very short notice.
Commentaire de “Traitement endoscopique du diverticule de Zenker: le choix des armes”, pp. 141, 131, 137, 146
Journal: Endoscopy (2007)

See also: Endotherapy of Zenker’s diverticulum using the needle-knife technique: long-term follow-upEndoscopy 2007; 39(02): 131-136DOI: 10.1055/s-2006-944657 See also: Treatment of Zenker’s diverticulum through a flexible endoscope with a transparent oblique-end hood attached to the tip and a monopolar forcepsEndoscopy 2007; 39(02): 137-140DOI: 10.1055/s-2006-945118 See also: Flexible endoscopic Zenker’s diverticulotomy: cap-assisted technique vs. diverticuloscope-assisted techniqueEndoscopy 2007; 39(02): 146-152DOI: 10.1055/s-2007-966140 See also: Argon plasma coagulation for flexible endoscopic Zenker’s diverticulotomyEndoscopy 2007; 39(02): 141-145DOI: 10.1055/s-2007-966164
Epidemiologic Detection of Low Dose Effects on the Developing Fetus
Authors: Jennie Kline, Bruce Levin, Zena Stein, Mervyn Susser, Dorothy Warburton
Journal: Environmental Health Perspectives (1981)

Evaluations of the health effects of exposures in the workplace and environment have broadened to include effects on reproduction, as well as on the development of cancer. Models to assess risks associated with varying doses of exposure rest almost entirely on data about cancer. In this paper we discuss some distinctive features of reproduction which bear on the interpretation of such models, when applied to reproduction, rather than carcinogenesis. Dose-response curves describe the relationship between two exposures (smoking and alcohol drinking) and two outcomes (spontaneous abortion and birthweight) are used to illustrate some of the questions which arise in attempting to determine a "safe" level of exposure.
Treatment of Fractures and Dislocations, 1950–1960
Authors: Thomas B. Quigley, Henry Banks
Journal: New England Journal of Medicine (1960)

The ElbowIt has become clear in recent years that in most elbow injuries the sooner active motion can be achieved, without aggravating the original trauma, the better the end result. This point of view has been well represented, together with a comprehensive review of standard practice, by Smith.75 Although activity too soon after injury undoubtedly can contribute to periarticular hemorrhage and its evolution into unwelcome masses of new bone (the "myositis ossificans traumatica" so strangely associated with the elbow), there is no real evidence that prolonged immobilization has any positive virtue in preventing the complication.Dissemination of clot and . . .
Abstract 843: Epigenomic disruption of adipogenic regulators in dedifferentiated liposarcoma
Authors: Hironori Takamatsu, Naoko Hattori, Naofumi Asano, Naoko Iida, Akihiko Yoshida, Eisuke Kobayashi, Robert Nakayama, Morio Matsumoto, Masaya Nakamura, Akira Kawai, Toshikazu Ushijima
Journal: Cancer Research (2019)

Abstract Well-differentiated liposarcomas (WDLPS) and dedifferentiated liposarcomas (DDLPS) are the most common soft-tissue sarcomas in adults. They develop as a result of a disturbance in adipogenic differentiation however, the epigenomic changes underlying liposarcomagenesis are unknown. Here, we aimed to elucidate the role of epigenomic alterations in the initiation of DDLPS. Genome-wide DNA methylation profiles of 15 liposarcoma (6 WDLPS and 9 DDLPS) samples and 6 normal adipose tissue samples were obtained using the Infinium MethylationEPIC BeadChip. After grouping neighboring probes into genomic blocks (GBs, &amp;lt; 500 bp), principal component analysis of all the CpG GBs (n = 535,684) was conducted. Each of normal adipose tissue and WDLPS grouped closely while DDLPS distributed broadly, indicating heterogeneous methylation profiles among the DDLPS samples. Unsupervised hierarchical cluster analysis of enhancers (2,000 GBs with the high SD of 23,478 GBs) classified the samples into three tissue types, whereas that of promoters (1,000 GBs with the high SD of 8,668 GBs) could not classify the DDLPS samples distinctly. The Jonckheere-Terpstra trend test revealed 9,945 hypermethylated (p &amp;lt; 0.01, Δβ &amp;gt; 0.2) GBs in DDLPS compared to those in normal adipose tissues and WDLPS samples. Based upon a report on enhancers in adipocytes (Mikkelsen et al. Cell 143, 156-169. 2010), the hypermethylated GBs in DDLPS were enriched with typical- (2.2%: whole genome 1.2%) and super- (13.5%: whole genome 7.0%) enhancers. Genes involved in adipogenesis, including PPARG2, the master regulator of adipogenesis, and its target genes (FABP4 and PLIN1), were aberrantly methylated at the enhancers and repressed in DDLPS. Conversely, promoters were not enriched among hypermethylated GBs in DDLPS (1.2%: whole genome 4.1%). Taken together, these data indicate that aberrant methylation at the enhancers of adipogenic genes might be crucial for the generation of DDLPS. Evaluation of a demethylating agent in combination with a PPARγ agonist as a potential therapeutic is in progress. Citation Format: Hironori Takamatsu, Naoko Hattori, Naofumi Asano, Naoko Iida, Akihiko Yoshida, Eisuke Kobayashi, Robert Nakayama, Morio Matsumoto, Masaya Nakamura, Akira Kawai, Toshikazu Ushijima. Epigenomic disruption of adipogenic regulators in dedifferentiated liposarcoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 843.
Masthead: (Adv. Healthcare Mater. 23/2017)
Journal: Advanced Healthcare Materials (2017)

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