tbuckley/cabot-search huggingface dataset:
Successful allogeneic stem‐cell transplantation with prophylactic stepwise G‐CSF primed‐DLIs for relapse after autologous transplantation in mantle cell lymphoma: A case report and literature review on the evidence of GVL effects in MCL
Authors: S.K. Sohn, J.H. Baek, D.H. Kim, J.T. Jung, D.S. Kwak, S.H. Park, J.S. Suh, K.B. Lee
Journal: American Journal of Hematology (2000)

Mantle cell lymphoma (MCL) is a distinctive clinicopathologic entity and represents 2–8% of all non-Hodgkin's lymphomas. The median survival of patients with MCL is only 3 years, and none of the available conventional chemotherapy regimens appears curative. Encouraging results have been reported with high-dose chemotherapy with autologous stem-cell transplantation (autoSCT). However, a plateau in disease-free survival was not observed in relapsed MCL on the autoSCT trials. Promisingly, alloSCT appears to induce durable remissions via a graft-versus-lymphoma (GVL) effect. Donor lymphocyte infusions (DLIs), by virtue of a GVL effect, have been shown to induce durable remissions in a few cases with refractory MCL that recur after alloSCT. In this article, we review the literature on the evidence of the GVL effects in MCL and describe a patient with relapsed MCL shortly after high-dose chemotherapy with autoSCT. The patient was then successfully treated with Bu/Cy/VP-16 for an alloSCT followed by DLIs in a stepwise fashion. MNCs > 10 × 108/kg were collected by two large-volume leukaphereses from the donor. Harvested stem cells from the 2nd day were cryopreserved for the future use as prophylactic DLIs to be given in a stepwise fashion. Cyclosporin and methotrexate were used for GVHD prophylaxis. He had achieved only a partial response by D+64 post transplant. G-CSF-primed cryopreserved DLIs were then infused on D+64 and D+92 to enhance the GVL effect. Grade 3 intestinal GVHD developed 20 days after the 2nd DLI and was partially controlled with the combination of cyclosporin, prednisone, and mycophenolate mofetil. Clinical complete remission was observed at D+112, and maintained until the last follow-up day (D+615). Our findings suggest that alloSCT followed by prophylactic DLIs may offer a curative approach to refractory MCL. Am. J. Hematol. 65:75–80, 2000. © 2000 Wiley-Liss, Inc.
New Consultant Contract
Authors: C. B. T. Adams, P. N. Awdry, J. Badenoch, P. R. Barton, J. H. Batstone, L. J. Belin, R. J. Berry, J. M. Black, F. J. Bolton, B. D. Bower, R. Bryce-Smith, S. Callender, B. H. Colman, R. Doll, M. S. Dunnill, P. M. Emerson, A. Freedman, J. M. D. Gallwey, M. H. Gough, R. A. Griffiths, A. J. Gunning, A. C. L. Houlton, J. T. Hughes, B. E. Juel-Jensen, J. G. G. Ledingham, E. G. Lee, G. d. J. Lee, W. S. Lund, R. G. Mitchell, C. H. Paine, R. J. Patterson, J. M. Potter, C. Prys-Roberts, J. Rayne, A. H. T. Robb-Smith, T. J. Ryan, A. A. Sharp, J. C. Smith, J. Stallworthy, A. S. Till, J. Tizard, D. C. Turk, H. R. Vickers, C. U. Webster, C. Westropp, R. Whitehead, C. W. M. Whitty, G. Wiernik, L. Wollner
Journal: BMJ (1973)
THE CURABILITY OF NASO-MUCOSITIS.
Authors: THOS. F. RUMBOLD
Journal: JAMA (1893)

Part I. The Way the Question is Put.—It is unprofitable to discuss an undefined subject. To ask one to build a house without giving its dimensions is not consistent with business principles, because the amount of work to be performed can not be estimated. To ask one as to the curability of a chronic disease without giving the age, physical condition, etc., of the patient is just as inconsistent. "Can you cure nasal catarrh?" is the universal form in which this question is put, by both the laity and the medical profession; in the former it is excusable; in the latter it is not. The question is asked precisely as one would ask about the removal of a corn from the foot, showing plainly an ignorance of the fact that the disease is found in various conditions, each of which must influence the ultimate result in any special case. On
Abstract 113: c-Kit-dependent tissue resident macrophage progenitors drive cancer progression
Authors: Paulina Pathria, Hideyuki Takahashi, Megan Kaneda, Minya Pu, Karen Messer, Ryan M. Shepard, Tiani L. Louis, Ann Shih, Mark Bertagnolli, Wolfgang Wrasidlo, David A. Cheresh, Judith A. Varner
Journal: Cancer Research (2019)

Abstract Macrophages play a key role in promoting tumor growth and resistance to therapy. Here we show that Tissue Resident Macrophages (TRM) as well as Bone Marrow-Derived Macrophages (BMDM) play critical but unique roles in promoting tumor growth. TRM were recently shown to originate in the yolk sac or fetal liver during embryogenesis; these cells self-maintain in post-natal tissues independent of hematopoietic stem cells. We found that BMDM are CD11b+Gr1+F4/80loCX3CR1loCCR2+and are recruited to tumors in a CCR2-dependent manner. In contrast, CD11b+Gr1-F4/80hiCX3CR1hiCCR2- TRMs accumulate in tumors independently of the trafficking receptor CCR2. Gene expression and functional studies indicate that tumor-derived TRM are highly proliferative, immune suppressive and distinct from BMDM. We show that TRM develop from c-Kit/c-KitL - dependent TRM progenitors that are abundant in tumors but not in normal tissues; purified progenitors form macrophages and potently stimulate tumor growth when adoptively transferred into mice. Tumor cells induce the expansion of TRM progenitors by secreting Stem Cell Factor (SCF/c-KitL). Notably, in vitro and in vivo proliferation of TRM progenitors and tumor growth are significantly inhibited by SCF and c-Kit inhibitors, including a novel, allosteric dual inhibitor of cKit and CDK8/19 that dramatically suppresses tumor growth by targeting both TRM and tumor cells. As cKit inhibitors synergize with other immune therapy regimens to suppress tumor growth, our studies identify cKit as a valuable target for immune therapy of solid tumors. Citation Format: Paulina Pathria, Hideyuki Takahashi, Megan Kaneda, Minya Pu, Karen Messer, Ryan M. Shepard, Tiani L. Louis, Ann Shih, Mark Bertagnolli, Wolfgang Wrasidlo, David A. Cheresh, Judith A. Varner. c-Kit-dependent tissue resident macrophage progenitors drive cancer progression [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 113.
Dipstick urinalysis screening of asymptomatic adults for urinary tract disorders. I. Hematuria and proteinuria
Authors: S. Woolhandler
Journal: JAMA (1989)

We review evidence on the value of dipstick urinalysis screening for hemoglobin and protein in asymptomatic adults. In young adults, evidence from five population-based studies indicates that fewer than 2% of those with a positive heme dipstick have a serious and treatable urinary tract disease, too few to justify screening and the risks of subsequent workup. For older populations, evidence is contradictory and no recommendation can presently be made for or against hematuria screening. A population-based randomized, controlled trial of hematuria screening in the elderly is urgently needed. Proteinuria screening is not recommended in any healthy, asymptomatic adult population, since four population-based studies have found that fewer than 1.5% of those with positive dipsticks have serious and treatable urinary tract disorders. (<i>JAMA</i>. 1989;262:1214-1219)
Report of the Medical Schools Section Primary Care Task Force
Authors: George T. Bryan, Robert M. Daugherty, William B. Deal, Joseph S. Gonnella, Michael J. Haller, Arthur D. Herold, Sam A. Nixon, Emery A. Wilson, Barbara Barzansky, Harry S. Jonas, Ira Singer
Journal: JAMA (1992)

THE percentage of physicians practicing a primary care specialty has declined, from about one half of total physicians in 1963 to about one third in 1986. One reason for this change is the retirement of general practitioners from medical practice.<sup>1</sup>These physicians are not being replaced at the same level, due to the decreased interest in primary care displayed by more recent US medical school graduates.<sup>2</sup>For example, results from the 1992 National Residency Matching Program showed that about 62% of the available positions in family practice, 64% of the positions in pediatrics, and 60% of the positions in internal medicine were filled with US seniors (memorandum from Norman Kahn, Jr, MD, American Academy of Family Physicians, to Commission on Education, March 17, 1992). In addition, 60% of the individuals initially entering residencies in internal medicine and 40% of those in pediatrics later pursue subspecialty training (Lyttle et
Cardiovascular effects of halothane in man. Studies during induction and sudden changes in concentration
Authors: N. T. Smith
Journal: JAMA (1968)

The cardiovascular response to induction of anesthesia with halothane-oxygen, as well as to changes in alveolar concentration from one steady-state level to another, was studied in eight subjects. Heart rate, arterial and right atrial pressures, stroke volume, cardiac output, left ventricular minute work, and total peripheral resistance were recorded beat-to-beat. The last four variables were calculated by a ballistocardiograph-analogue computer system. Induction of anesthesia significantly increased all variables except total peripheral resistance and arterial and right atrial pressures. The last two are the variables conventionally measured during anesthesia and surgery. The response to changing concentration was significantly delayed in time and decreased in magnitude late, as compared to early, in anesthesia administration, which indicated an adaptation to halothane anesthesia. The changes noted during induction in our healthy, normal subjects should be transferred with caution to the situation in the operating room.
Prevalence of antibody to HIV-1 among entrants to US correctional facilities
Authors: D. Vlahov
Journal: JAMA (1991)

Prevalence of antibody to the human immunodeficiency virus type 1 (HIV-1) was assessed among 10 994 consecutive male and female entrants to 10 correctional systems in the United States. The HIV-1 seroprevalence for the 10 systems ranged from 2.1% to 7.6% for men and 2.5% to 14.7% for women; seroprevalence among women was higher than among men across nine of 10 systems. Using age 25 years to divide the population, HIV-1 prevalence among young women (5.2%) was significantly higher than among young men (2.3%), but similar to that in both older women (5.3%) and older men (5.6%). Overall, HIV-1 rates for nonwhites (4.8%) were higher than those for whites (2.5%). Although categories were identified across correctional systems, which may serve to focus prevention programs, variability in rates among correctional systems indicates that program planning must take local conditions into consideration. (<i>JAMA</i>. 1991;265:1129-1132)
Masters of Medicine.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hippocrates' Contributions
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Injuries of the sporting knee
Authors: I Corry, J Webb
Journal: British Journal of Sports Medicine (2000)

The first article in this series drew attention to the evidence that ligament damage is more common than any other type of knee injury pathology.The mean delay from anterior cruciate ligament (ACL) injury to diagnosis at a specialist knee clinic was reported as 22 months.The management of the resulting instability from isolated ligament injuries and from more complex injuries is the subject of this the next article in the series.The paper has been written by Derek BickerstaV and Trinath Kakarlapudi from the Northern General Hospital in Sheffield.Derek BickerstaV has a special interest in complex knee injuries and revision surgery.He is a member of the advisory committee producing national guidelines for the practice of ACL reconstruction and he has close associations with top level teams in several sports.Since his sports surgery fellowship in Adelaide, Australia, he has published and presented prolifically on the subject of knee injuries.His colleague, Trinath Kakarlapudi, is a specialist registrar who has just begun a fellowship in knee surgery in Toronto, Canada.The article addresses the issues of assessment, treatment, and rehabilitation of the major isolated ligament injuries as well as the common combined instability patterns.It makes the point that treatment is aimed at restoring stability and function rather than preventing long term degenerative change, as there is no evidence that reconstruction reduces the development of arthritis.However, evidence is emerging that ACL reconstruction may reduce the incidence of subsequent meniscal damage and allow retention of their protective eVect.ACL reconstruction is now such a popular and common operation world wide that data comparing the long term results of modern methods of reconstruction with the natural history of the deficient knee will soon be available.For the future, the challenges mentioned are prevention of associated degenerative change and advances in prosthetic structures rather than grafts.
New Classes of Environmental Tumor Promoters: Indole Alkaloids and Polyacetates
Authors: Hirota Fujiki, Takashi Sugimura, Richard E. Moore
Journal: Environmental Health Perspectives (1983)

Tumor promoters are known to induce ODC activity in mouse skin and that this induction can be inhibited by the application of 13-cis-retinoic acid. These two properties of tumor promoters were utilized for screening new tumor promoters in our environment. Two new classes of tumor promoters are presented: indole alkaloids (teleocidin and lyngbyatoxin A) and polyacetates (aplysiatoxin and debromoaplysiatoxin). Teleocidin from streptomyces and lyngbyatoxin A, from the blue-green alga, Lyngbya majuscula, were able to induce ODC activity in mouse skin and showed various biological activities similar to those of TPA. Teleocidin and lyngbyatoxin A are indole alkaloids. Their tumor promoting activities became apparent in the mouse skin through a two-stage carcinogenicity test. The tumor incidence of the group treated with DMBA plus teleocidin was 100% at week 30, which was similar to that of the group given DMBA and TPA. The in vivo carcinogenicity test with lyngbyatoxin A is still underway. The tumor incidence of the group treated with DMBA plus lyngbyatoxin A is 80% at week 21. A second new class of tumor promoter is polyacetate. Aplysiatoxin and debromoaplysiatoxin were isolated from another variety of blue-green alga. Aplysiatoxin and debromoaplysiatoxin induce ODC to the same degree of potency. However, aplysiatoxin induced various membrane effects, such as adhesion of cells and turnover of phospholipid with a similar concentration of TPA, teleocidin and lyngbyatoxin A. On the other hand, debromoaplysiatoxin required an amount almost 100 times greater to achieve the same effects. We are convinced of the possibility that various classes of tumor promoters exist in our environment.
THE ABUSE OF THE FOOT.
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical implication of circulating hepatocellular carcinoma cells in peripheral blood Department of Medicine and Clinical Science, Kyoto Univ. Graduate School of Medicine, Kyoto, Japan
Journal: Hepatology (1995)

The increasing gap between the number of patients who could benefit from liver transplantation and the number of available donors has fueled efforts to maximize the donor pool using marginal grafts that usually were discarded for transplantation. This study included data of all patients who received decreased donor liver grafts between January 2004 and January 2013 (n = 218) with the use of a prospectively collected database. Patients with acute liver failure, retransplantation, pediatric transplantation, and split liver transplantation were excluded. Donors were classified as standard donor (SD), extended criteria donor (ECD), and overextended criteria donor (OECD). The primary endpoints of the study were early allograft primary dysfunction (PDF), primary nonfunction (PNF), and patient survival (PS), whereas incidence of major postoperative complications was the secondary endpoint. In our series we demonstrated that OECD have similar outcome in terms of survival and incidence of complication after liver transplantation as ideal grafts.
Deafness, Nephritis and Lens Disease
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pulmonary Langerhans Cell Granulomatosis (Histiocytosis X)
Authors: P Soler
Journal: Annual Review of Medicine (1992)

Postpartum depression (PPD) is common, disabling, and treatable. The strongest risk factor is a history of mood or anxiety disorder, especially having active symptoms during pregnancy. As PPD is one of the most common complications of childbirth, it is ...Read More
Learning theories implicit in medical school lectures
Authors: R. I. Cook
Journal: JAMA (1989)

FACULTY lectures are the primary method for teaching first- and second-year medical students. Lecture styles have an enduring quality of sameness that suggests that the lecturers possess unvarying theories about the value of lectures and the way medical students learn. Medical school faculty rarely have formal training as educators, and four out of five have never had a college-level course in teaching.<sup>1</sup>Their lecture styles must be derived from personal experience as students and later as faculty; their approaches to lectures may not have anything in common with those of educational theorists.<sup>2,3</sup> Observation suggests that faculty subscribe to different theories of medical student learning. The theories include<i>passive diffusion, receptor, queuing</i>, and<i>vigilance</i>. A few lecturers use a style inconsistent with any underlying theory, apparently believing that learning does not occur during lectures. The underlying learning theories (or lack of theory) implicit in each style are discussed herein.