Cytokines in Polymyalgia and Giant Cell Arteritis
Authors: Cornelia M. Weyand
Journal: Annals of Internal Medicine (1995)

Letters15 April 1995Cytokines in Polymyalgia and Giant Cell ArteritisCornelia M. Weyand, Jorg J. Goronzy, and Gene G. HunderCornelia M. WeyandIndiana Internal Medicine Consultants, Indianapolis, IN 46227. Mayo Foundation, Rochester, MN 55905.Search for more papers by this author, Jorg J. GoronzyIndiana Internal Medicine Consultants, Indianapolis, IN 46227. Mayo Foundation, Rochester, MN 55905.Search for more papers by this author, and Gene G. HunderIndiana Internal Medicine Consultants, Indianapolis, IN 46227. Mayo Foundation, Rochester, MN 55905.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-122-8-199504150-00027 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Dr. Greenbaum addresses an important question. What is the exact relation between giant cell arteritis and polymyalgia rheumatica? Our study [1] on tissue cytokines was designed to investigate whether and to what extent these diseases share pathogenetic mechanisms. In current clinical practice, polymyalgia rheumatica remains to some extent a diagnosis of exclusion. Because temporal artery vasculitis can be missed due to the patchy nature of the disease, we examine biopsy specimens from the contralateral temporal artery of patients suspected of having giant cell arteritis if cryosections of the first biopsy specimen are negative for the disease. Biopsy specimens ...References1. Weyand CM, Hicok KC, Hunder GG, Goronzy JJ. Tissue cytokine patterns in patients with polymyalgia rheumatica and giant cell arteritis. Ann Intern Med. 1994; 121:484-91. Google Scholar2. Hall S, Lie JT, Kurland LT, Persellin S, O'Brien PC, Hunder GG. The therapeutic impact of temporal artery biopsy. Lancet. 1983; 2:1217-20. Google Scholar3. Weyand CM, Hicok KC, Hunder GG, Goronzy JJ. The HLA-DRB1 locus as a genetic component in giant cell arteritis. Mapping of a disease-linked sequence motif to the antigen binding site of the HLA-DR molecule. J Clin Invest. 1992; 90:2355-61. Google Scholar4. Weyand CM, Hunder NN, Hicok KC, Hunder GG, Goronzy JJ. HLA-DRB1 alleles in polymyalgia rheumatica, giant cell arteritis, and rheumatoid arthritis. Arthritis Rheum. 1994; 37:514-20. Google Scholar5. Wagner AD, Gorozny JJ, Weyand CM. Functional profile of tissue proliferating and circulating CD68+ cells in giant cell arteritis. Evidence for two components of the disease. Clin Invest. 1994; 94:1134-40. Google Scholar Author, Article, and Disclosure InformationAuthors: Cornelia M. Weyand; Jorg J. Goronzy; Gene G. HunderAffiliations: Indiana Internal Medicine Consultants, Indianapolis, IN 46227. Mayo Foundation, Rochester, MN 55905. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited by5 Large vessel vasculitis (giant cell arteritis, Takayasu arteritis) 15 April 1995Volume 122, Issue 8Page: 634KeywordsArteriesBiopsyCytokinesGiant cellsMessenger RNAMonocytesPathogensPolymyalgia rheumaticaSigns and symptomsVasculitis ePublished: 15 August 2000 Issue Published: 15 April 1995 Copyright & PermissionsCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...