tbuckley/cabot-search huggingface dataset:
JAMA Psychiatry
Authors: Phil Fontanarosa, Annette Flanagin, Brenda Gregoline, Tracy Frey, Kevin Brown, Amanda Ehrhardt, Iris Lo, M Newman, Suzanne Walker, Connie Manno, Sara Billings, Timothy Gray, Paul Ruich, Sam Wilder, Catherine Alden, Stephanie Beckmeyer, Jane Calayag, Jan Clavey, Mary Coerver-Connolly, Paula Glitman, Lila Haile, Laura King, Regina Lilly, Thressa Smith, Donna Thordsen, Carolina Woods, Aggie Zarkadas, Wanda Assistant, Larry Bryant, Jacob Kendall-Taylor, Monica Mungle, Fanny Brown, Anna Bukowski, Lee Calibeo, Lenette Gardner-Gullens, Tosca Hall, Erin Kato, Rachell Lozano, Caroline Sietmann, Angelia Waltower, Michael Berkwits, Eric Butkus, Michelle Kurzynski, Emily Ling, Jesse Mcquarters, Daniel Morrow, Daniella Peting, Reuben Rios, Carrie Butt, Mary Ferkaluk, Karen Bucher, Andy Rekito, Nick Reback, David Song, Deputy Livingston, Thomas Cole, Marla Hall, Deanna Willis, Yolanda Davis, Joseph Thornton, Deanna Bellandi, Jim Periodical, Thomas Easley, Brian Shields, Karen Adams-Taylor, Paul Gee, Monica Smith, Jeff Ery, J Bonistalli, Kathy Russell, Mirna Monal, Stacey Mchugh, Marketing Thornbury, Tricia Classifi, Thalia Moss, Tony Ralenkotter, Saskia Bolore, Gretchen Linder, Brian Mccartney, Christine Hearne, Natasha Staff, David Baum, Morgan Osgood, Ron Thomas, Rick Bell, Elizabeth Solaro, Sara Zimmerman, Geoff Rey, Fergus Clare, Lindsay Dawson, Ellen Gibson, Mustafa Ishaq, Peter Litton, Craig Mccaff Rey, Michael Mcgraw, Regina Nisengolts, Jon Perkins, Daniel Pickhardt, Romando Rossini, Sarah Subramanian, Stacy Business, Analyst Sirisha, Alluri Staff, Millette Jackson-Bates, Tom Miller, Karl Elvin, Nancy Essex, Jaye Mize, Sean O'donnell, Sue Managers, David Antos, Anthony Bautista, Chris Borden, Debbie Camp, Jennifer Carney, Lydia Cruz, Scott Curl, Diane Darnell, Jordynn Farrar, Allison Hughes, Colleen Kelly, Chris Meyer, Annemarie Neff, J Neff, Sean Ohlson, Phil O'leary, Bill Pedone, Susan Price, Binita Shah, Erin Spencer, Denise Steinhauser, Joe Advertising, Production Services, Ahmed Avendano, Kim Boler, Rhonda Brown, Fin Carter, Michael Deegan, Daniel Degroot, Euwanaha Joiner-Smith, Joshua Lane, Cindy Rendlen, Ellen Yoshihara, Circulation Services, Julie Burton, Ronna Hewitt, Mary Sieck, Geneine Someren, Jamaal Vargas, New Media, Gail Barrett, Regina Brownlee, Amanda Camino, Brenda Chandler-Grayer, Emily Dunn, Amy Evers, Maleeka Holden, Teri Hutchison, Joshua Lampinen, Nathan Mitre, Patricia Panek, Marla Seidell, La Son, Diggs Sledge, Julian Graphics, Joe Amft, James Collver, Maria Duda, Fred Furtner, Carolyn Hall, Maria Kowalkowski, Carla Benton, Carol Farrell, Daniel James, Judith Literskis, Teresa Omiotek, Michael Ryder, James Madara, Bernard Hengesbaugh, Sara Dibari, Martin Paulus, Helen Simpson, New York, John Torous, Helena Chmura Kraemer, Palo Alto, Howard Bauchner
Journal: JAMA Psychiatry (2018)
Conference on Problems of Aging: Transactions of the Thirteenth Conference, February 5-6, 1951, New York, N. Y.
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fetal Loss and Caffeine Intake
Authors: Ming Wei
Journal: JAMA (1994)

<h3>To the Editor.</h3> —Dr Infante-Rivard and colleagues<sup>1</sup>report important findings that fetal loss was not only associated with coffee intake during pregnancy, but also related to coffee intake before pregnancy. However, I am not convinced of the validity of the findings. I am concerned about potential bias and confounding. It is well known that fetal loss is strongly related to tobacco smoking and heavy consumption of alcohol, but less consistently related to caffeine consumption.<sup>2</sup>However, the authors report that the risk of spontaneous abortion was almost identical in smokers and nonsmokers and in drinkers and nondrinkers. At the same time, they found that this risk was strongly associated with caffeine intake in this study.<sup>1-3</sup> It is important to note that the original goal of their study was not to assess the relationship between caffeine intake and fetal loss. Data on smoking, use of alcohol, and caffeine drinking
Abstract 1563: Stool proteomics reveals novel candidate biomarkers for colorectal cancer screening
Authors: Linda JW Bosch, Meike de Wit, Annemieke C. Hiemstra, Sander Piersma, Thang Pham, Gideon Oudgenoeg, George Scheffer, Sandra Mongera, Malgorzata Komor, Jochim Terhaar Sive Droste, Frank A. Oort, Sietze van Turenhout, Ilhame Ben Larbi, Chris JJ Mulder, Beatriz Carvalho, Remond JA Fijneman, Connie Jimenez, Gerrit A. Meijer
Journal: Cancer Research (2015)

Abstract Introduction and objectives: Early detection of colorectal cancer (CRC) and its precursor lesions is an effective approach to reduce CRC mortality rates. The fecal immunochemical test (FIT) is a non-invasive CRC screening test that detects small traces of the blood protein hemoglobin. Although beneficial in its current form, the FIT test characteristics leave room for improvement. The aim of the present study was to identify and validate novel protein biomarkers in stool that complement or outperform the current hemoglobin-based test, to improve its diagnostic accuracy. Methods: Proteins isolated from stool from 10 subjects without any signs of colorectal neoplasia (controls) at colonoscopy and from 12 CRC patients were analyzed by GeLC-MS/MS (discovery set). Data were analyzed by comparing protein abundancies, measured as spectral counts. Analysis of differential proteins was performed using the beta-binomial test. Findings were validated by mass spectrometry (Q-Exactive) in an independent series of 292 stool samples obtained from control subjects (n = 109) and subjects with adenomas (n = 55), advanced adenomas (n = 53), or CRCs (n = 75). Results and Discussion: In total 830 human proteins were identified in the discovery set, of which 134 were significantly enriched in CRC. These included 78 proteins that were significantly more enriched in FIT-negative CRC stool samples compared to controls. Preliminary analysis of the validation set indicates that more than half of these markers are significantly more abundant in CRC samples compared to controls. Conclusion: Proteome profiling of stool samples revealed novel candidate biomarkers to improve current CRC screening tests. More data analysis is currently ongoing to select most promising protein biomarkers for clinical assay development. Citation Format: Linda JW Bosch, Meike de Wit, Annemieke C. Hiemstra, Sander Piersma, Thang Pham, Gideon Oudgenoeg, George Scheffer, Sandra Mongera, Malgorzata Komor, Jochim Terhaar Sive Droste, Frank A. Oort, Sietze van Turenhout, Ilhame Ben Larbi, Chris JJ Mulder, Beatriz Carvalho, Remond JA Fijneman, Connie Jimenez, Gerrit A. Meijer. Stool proteomics reveals novel candidate biomarkers for colorectal cancer screening. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 1563. doi:10.1158/1538-7445.AM2015-1563
The effects of the 3-hydroxy, 3-methylglutaryl coenzyme A reductase inhibitor pravastatin on bile composition and nucleation of cholesterol crystals in cholesterol gallstone disease*1
Authors: J SMIT
Journal: Hepatology (1995)

3-hydroxy,3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors reduce biliary cholesterol saturation index (CSI) in duodenal bile in hypercholesterolemic patients and might be useful for gallstone dissolution. However, preliminary data suggest that these drugs are not effective in this respect. We therefore studied 33 patients with radiolucent gallstones in an opacifying gallbladder who were scheduled for elective cholecystectomy. Patients were treated with 40 mg pravastatin day−1 or placebo during the 3 weeks before surgery. Six patients could not be evaluated. Baseline characteristics (age, sex, body mass index, serum cholesterol, and the solitary/multiple gallstone ratio) were similar in both groups. Serum cholesterol fell by 39% in the pravastatin group (P < .001) and remained unchanged in the placebo group. Biliary cholesterol (9.5 ± 1.3 vs. 14.3 ± 1.5 mmol/L, P = .026), and phospholipid concentrations (24.8 ± 3.9 vs. 36.7 ± 3.9 mmol/L, P = .043) were lower in the pravastatin group. Although bile salt concentrations were lower in the pravastatin group (114 ± 21 vs. 152 ± 15 mmol/L), this difference was not significant. CSI was not different between both groups (142 ± 27% [pravastatin]vs. 113 ± 6% [placebo], P = NS). Cholesterol crystals were present in fresh bile in 7 of 13 patients in the pravastatin group and in 11 of 14 controls (P = NS). Nucleation time was comparable between the 2 groups (13 ± 3 vs. 9 ± 3 days, P = NS). Bile salt species and molecular species of phospholipids determined with high-performance liquid chromatography did not differ either between both groups. Not only cholesterol but also phospholipid concentrations decrease in gallbladder bile during pravastatin treatment in cholesterol gallstone patients, with comparable CSI and nucleation time. This study does not support the use of HMG-CoA reductase inhibitors for dissolution of cholesterol gallstones.
COSMIC MICROBES.
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lupus-erythematosus-like tinea of the face (tinea faciale)
Authors: R. S. Gilgor
Journal: JAMA (1971)

Fourteen patients had superficial fungus infections of their faces. Over half of them were misdiagnosed, usually as a sunlight-related disorder. The correct diagnosis can usually be made by direct examination of scales or blister roofs, taken from affected areas, or by fungus culture. All patients responded rapidly to antifungal treatment.
Final Fellowship: Correction
Authors: Arthur Keith, W Pryor, Mary App, ! Eby, E Bailey, P Barford, R Barnes, C Bekenn, J Bostock, D Brown, Hi Burtt, H Caplan, Doris Carrington, Olive Coldicott, A Davies, Elsie Davies, H Donovan, T Donovan, Dorothy Elliott, Vera Fellowes, J Field, F Gould, D Irene, F Hastilow, L Healy, W Hill, A Hodgson, H Jukes, D Magrath, Evelyn May, Muriel Nawar, J Phipp3, C Pike, L Robb, B Taylor, Eileen Thomason, G Williams, L Wilson, Gilbert Barling, Mr Beckwith Whitehouse, J Maclure, Mr Bernard, G Goodwin, F Martin, V St, G Keays, Elspethv Pienaar, M Hewat, I Clarke, R Henry, G Purdy, J Thomnpson, J Stuart, J Armstrong, J Beatty, G Garde
Journal: BMJ (1924)
AGRANULOCYTIC ANGINA
Authors: James H. Skiles
Journal: JAMA (1925)

In a recent article<sup>1</sup>agranulocytic angina is described, and a case occurring in Chicago is reported. As far as is known, this case of Dr. Lovett's is the first case described in America. The case here reported fits so perfectly the picture of Dr. Lovett's case that it seems proper to record it. <h3>REPORT OF CASE</h3><h3>History.</h3> —Mrs. C., a widow, aged 33, who entered the West Suburban Hospital, Oct. 18, 1924, had always been well. The family history was negative. She had two healthy children. The onset of present complaint was about one week before entrance. It began with sore throat and sore gums, chills and fever and general malaise. There was considerable headache, no cough or dyspnea, no nausea, no vomiting, and no bowel or urinary disturbance. The day after entrance, large gray patches were found on the palate, gums, and margins of many of the teeth.
Busulfan treatment of leukemia during pregnancy. Case report and review of the literature
Authors: M. Dugdale
Journal: JAMA (1967)

WHEN PREGNANCY occurs in a patient with leukemia, a difficult therapeutic problem is presented to the physician. Almost invariably it is necessary to treat the patient with antileukemic drugs during the course of the pregnancy. The drugs commonly used in the therapy of the leukemias are potent cytotoxic agents. Does their use endanger the fetus? In experimental animals, these drugs cross the placental barrier and cause varying degrees of damage to the fetus.<sup>1</sup>Their effect on the human fetus, however, is less clearly defined. Case reports of leukemic patients treated during pregnancy are often difficult to evaluate since multiple drugs were used. Only in those instances where a single agent was used can we obtain information regarding its specific effect on the pregnancy or the health and development of the fetus. We wish to report such a case in which busulfan (Myleran) was the sole form of therapy throughout
Errors in the Abstract, Results Section, and Table 2
Authors: Gary Foster
Journal: JAMA Pediatrics (2019)

Heather M. Polonsky, MS; Katherine W. Bauer, PhD; Jennifer O. Fisher, PhD; Adam Davey, PhD; Sandra Sherman, EdD; Michelle L. Abel, MSPH; Alexandra Hanlon, PhD; Karen J. Ruth, MS; Lauren C. Dale, BS; Gary D. Foster, PhD
LETTER FROM NEW YORK.
Authors: None P. B. P.
Journal: JAMA (1889)

(FROM OUR OWN CORRESPONDENT.) The Relation of the Tubercle Bacillus to the Etiology of Phthisis—to the Early Diagnosis and Prognosis of Phthisis—The Specific Nature of Phthisis—The Influence of the Microbe Theory on the Treatment of Phthisis. At the first meeting in May, of the Academy of Medicine, Dr. W. B. James read a paper on<i>The Relation of the Tubercle Bacillus to the Etiology of Phthisis</i>. The result of the enormous number of original investigations which had been carried on since the discovery of the bacillus, in 1882, he said, had been to confirm the correctness of Koch's conclusions. It was also fairly well established now that the tuberculous process is capable of setting up inflammatory action in adjacent tissues which may be either acute on chronic in character. By pulmonary phthisis he understood a tuberculous inflammation of the lungs, and he therefore considered any secondary and contributing cause or
Cover Image, Volume 39, Issue 1
Authors: N. G. R. Dayan Elshan, Matthew B. Rettig, Michael E. Jung
Journal: Medicinal Research Reviews (2018)

On the cover: The cover image, by N. G. R. Dayan Elshan et al., is based on the Review Article Molecules Targeting the Androgen Receptor (AR) Signaling Axis Beyond the AR-Ligand Binding Domain, DOI: 10.1002/med.21548.
SYMBOLS FOR EYE PHENOMENA DURING ANESTHESIA
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Quinidine Therapy of Chronic Auricular Fibrillation
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
How far should blood pressure be lowered in treating hypertension
Authors: E. D. Freis
Journal: JAMA (1975)

ONE OF the most troublesome problems in the treatment of hypertension is management of the poorly responsive patient. Despite effective doses of several antihypertensive agents given in combination, there still remain some patients whose blood pressures are only partially reduced toward normal. In some cases, lack of success is due to poor compliance on the part of the patient, but in other instances, blood pressure is not well controlled despite reasonable compliance. What should the physician do under the latter circumstances? Should he pursue a more aggressive program, or should he settle for the best possible reduction he can obtain within the limitations imposed by side effects? Some authorities have set as their minimum goal in treatment the achievement of a diastolic blood pressure below 90 mm Hg. If this is the criterion of therapeutic success, there will be a sizable number of treatment failures, and many patients will become
Trends in HIV/AIDS Diagnoses Among Men Who Have Sex With Men—33 States, 2001-2006
Journal: JAMA (2008)

In 2008, CDC conducted an analysis of trends in diagnoses of human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) among men who have sex with men (MSM) in the 33 states that have had confidential, name-based HIV case reporting since at least 2001. This report summarizes the results of that analysis, which indicated that the number of HIV/AIDS diagnoses among MSM overall during 2001-2006 increased 8.6% (estimated annual percentage change [EAPC] = 1.5). During 2001-2006, an estimated 214,379 persons had HIV/AIDS diagnosed in the 33 states. Of these diagnoses, 46% were in MSM, and 4% were in MSM who engaged in illicit injection-drug use (IDU) (i.e., MSM and IDU). To reduce the impact of HIV/AIDS in the United States, HIV prevention services that aim to reduce the risk for acquiring and transmitting infection among MSM and link infected MSM to treatment must be expanded.
Community Health Profile of Windsor, Ontario, Canada: Anatomy of a Great Lakes Area of Concern
Authors: Michael Gilbertson, James Brophy
Journal: Environmental Health Perspectives (2001)

The rates of mortality, morbidity as hospitalizations, and congenital anomalies in the Windsor Area of Concern ranked among the highest of the 17 Areas of Concern on the Canadian side of the Great Lakes for selected end points that might be related to pollution in this relatively highly industrialized city.Mortality and morbidity rates from all causes were higher than in the rest of the province.Anomalously high rates of diseases included various cancers; endocrine, nutritional, metabolic, and immunity disorders; diseases of the blood and blood-forming organs, nervous system and sense organs, circulatory and respiratory systems, digestive system, genitourinary system, skin and subcutaneous tissue, musculoskeletal system and connective tissues; congenital anomalies, and infant mortality.Of particular concern was the early onset of the elevated rates of many of these diseases and conditions.Comparison of these incident rates with those in Hamilton, another industrial municipality in southern Ontario, suggested that in addition to a variety of local sources of industrial pollution from automobile manufacturing and use, transboundary air and water pollution from Detroit, Michigan, should be investigated as potentially important causes of these health outcomes in the Windsor Area of Concern.Some of the institutional and political trends of the past decade may need to be reversed before effective remedial programs are implemented for cleaning up contaminated sediments and for containment of leaking hazardous waste sites.This pilot project would seem to be a useful preliminary method of integrating human health concerns and of priority setting for the administration of the Great Lakes Water Quality Agreement and the Canada-United States Air Quality Agreement.
Back pain in a young man
Authors: R. A. Seltzer
Journal: JAMA (1966)

Dr. William J. Otto: An 18-year-old white boy entered the hospital complaining of back pain of seven months' duration. The pain was constant but was relieved by mild analgesics. It radiated into the left leg to the lateral malleolus. He was seen at another hospital four months previously where a myelogram was said to be normal. There was no history of trauma or sudden strain. Physical examination revealed tenderness over the fourth lumbar vertebra posteriorly and limitation of straight-leg raising on the left. Results of neurological examination were normal. All laboratory findings were within normal limits. <h3>Discussion</h3> Dr. Jack R. Dreyfuss: There is a lucent area, 11 mm in diameter, located in the superior aspect of the left lamina of the fifth lumbar vertebra (Figure,<i>left</i>). A laminagram (Figure,<i>right</i>) shows a small zone of sclerosis surrounding the defect and a suggestion of a small area of increased density within