tbuckley/cabot-search huggingface dataset:
Effect of cytochrome P450 induction on phosphorus metabolites and proton relaxation times measured by in vivo 31P-magnetic resonance spectroscopy and 1H-magnetic resonance relaxometry in human liver
Authors: W Block
Journal: Hepatology (1997)

Experimental and clinical studies have led to the hypothesis that the phosphodiester signal obtained by 31P magnetic resonance (MR) spectroscopy may be a specific marker for the hepatic induction of oxidative metabolism (P450 induction) by phenobarbitone or ethanol. Systematic studies in humans are lacking. Therefore, we studied 10 volunteers who received rifampin (600 mg/d) for 6 days, resulting in a documented induction of oxidative metabolism as measured by an increase in urinary 6-beta-hydroxycortisol output in all volunteers (P = .0004). 31P-MR spectroscopy and 1H-MR relaxometry were performed before and after hepatic P450 induction. As shown by 31P-MR spectroscopy, the median phosphomonoester concentration (PME) relative to nucleoside triphosphate (NTP) increased by 21% from 0.63 (range, 0.40-0.89) before induction to 0.76 (0.49-1.67) after induction (P ≤ .0451). The median level of phosphodiesters (PDE) relative to NTP increased by 28% from 4.82 (3.41-6.67) before induction to 6.18 (4.63-11.63) after induction (P = .0091). An increase in the level of inorganic phosphates (Pi) relative to NTP was observed, but changes were not significant. As shown by 1H-MR relaxometry, a nonsignificant trend of the liver parenchyma to shorter relaxation times was observed after P-450 induction. In conclusion, both PME/NTP and PDE/NTP ratios (measured by in vivo 31P-MR spectroscopy) increased significantly after hepatic induction with rifampin. Further clinical studies with 31P-MR spectroscopy must take into account the potential effects of P450- inducing agents. (Hepatology 1997 Dec;26(6):1587-91)
REDUCING BODIES IN THE URINE OF CHILDREN AND THE SAFRANIN TEST.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
QuickStats: Percentage* of Adults† Who Were Prescribed Medication by a Doctor or Other Health Care Professional During the Past 12 Months,§ by Poverty Status¶ — National Health Interview Survey, United States, 2014**
Journal: MMWR Morbidity and Mortality Weekly Report (2016)

Department of Health and Human Services/Centers for Disease Control and Prevention * Percentages shown with 95% confidence intervals as error bars.† Aged ≥18 years.§ Based on the response of "yes" to the survey question, "During the past 12 months, were you prescribed medication by a doctor or other health professional?"¶ Poverty status is based on family income and family size using the annually updated U.S. Census Bureau poverty thresholds.Family income was imputed when missing.** Estimates are based on household interviews of a sample of the civilian, noninstitutionalized U.S. population and are derived from the National Health Interview Survey sample adult component.
Prolonged anticoagulation in rat poisoning
Authors: E. C. Jones
Journal: JAMA (1984)

RODENTICIDES often contain warfarin or warfarinlike compounds as their active ingredient. The anticoagulant effects of human rodenticide poisoning do not, however, necessarily mimic those of a simple warfarin effect. This article reviews a case of human rodenticide poisoning with a very prolonged anticoagulant effect. The rodenticide's active ingredient is brodifacoum (marketed as Ratak[unk] in Canada and Talon[unk] in the United States), a recently developed coumarin anticoagulant that is effective against warfarin-resistant rats.<sup>1</sup>This case shows that its anticoagulant effect in humans is similar to that seen in animal studies.<sup>2</sup> <h3>Report of a Case</h3> On Aug 10, 1983, a 17-year-old adolescent, weighing 65 kg, attempted suicide by ingesting approximately 7.5 mg (0.12 mg/ kg) of brodifacoum in a commercially available rodenticide. This was his first ingestion of a rodenticide and he denied taking any other toxic agents. Before this he had been in good physical health.
MEDICAL STANDARDS AND THE PUBLIC SERVICES.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Q Fever
Authors: Daniel M. Musher
Journal: JAMA (1968)

In an area known for endemic Q fever, eight of 52 cases of nonbacterial pneumonia were proven to be caused by infection with<i>Coxiella burnettii</i>. Intimate contact with a possible source of infection was excluded in all patients and dust-borne transmission of the rickettsial organism from animal to man was implicated. Symptoms, physical findings, and laboratory and roentgenographic data were similar to those previously described in Q fever and were indistinguishable from those found in viral or mycoplasmal pneumonia. All patients treated with tetracycline showed a dramatic response within 24 hours. Q fever must be considered in the diagnosis whenever nonbacterial pneumonia occurs in late summer or early fall in an area where Q fever is endemic. Early diagnosis and treatment will significantly reduce morbidity.
HERPBTIC DISEASES*
Authors: J. R. PERDEAU
Journal: British Journal of Dermatology (1927)

Journal Article HERPBTIC DISEASES Get access J. R. PERDEAU, M.B J. R. PERDEAU, M.B From the National Institute for Medical Research, Hampstead, N. W. 3 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 39, Issue 1, 1 January 1927, Pages 1–13, https://doi.org/10.1111/j.1365-2133.1927.tb10023.x Published: 01 January 1927
Twenty-Fourth Postgraduate Institute for Pathologists in Clinical Cytopathology
Journal: JNCI Journal of the National Cancer Institute (1982)

Journal Article Twenty-Fourth Postgraduate Institute for Pathologists in Clinical Cytopathology Get access JNCI: Journal of the National Cancer Institute, Volume 69, Issue 3, September 1982, Page 745, https://doi.org/10.1093/jnci/69.3.745-b Published: 01 September 1982
Personal Care
Authors: ERIC WALL
Journal: Annals of Internal Medicine (1980)

Letters and Corrections1 May 1980Personal CareERIC WALL, M.D.ERIC WALL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-92-5-721_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In his recent thought-provoking article, Burnum (1) makes a compelling case in support of the scientific value of personal care. Since the notion of personal care is central to every definition of primary care, it seems worth examining this issue further.According to Burnum, personal care encompasses the non-technologic aspects of health care that pay attention to a patient's "subjective experience of disease." I first question whether such a definition is, by itself, necessary and complete. "Personal care" describes its own focus—personalized or individualized caring—with impersonal care being a contradiction in terms. As such, I wonder whether...Reference1. BURNUM J. The "scientific" value of personal care. Ann Intern Med. 1979;91:643-4. Editorial. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ERIC WALL, M.D.Affiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1980Volume 92, Issue 5Page: 721-721KeywordsHealth care ePublished: 1 December 2008 Issue Published: 1 May 1980 PDF downloadLoading ...
Impotencia sexual masculina
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Voxelwise Correlational Analyses of White Matter Integrity in Multiple Cognitive Domains in Schizophrenia
Authors: Kelvin Lim
Journal: American Journal of Psychiatry (2006)

Patients with schizophrenia show deficits in several neurocognitive domains. However, the relationship between white matter integrity and performance in these domains is poorly understood. The authors conducted neurocognitive testing and diffusion tensor imaging in 25 patients with schizophrenia. Performance was examined for tests of verbal declarative memory, attention, and executive function. Relationships between fractional anisotropy and cognitive performance were examined by using voxelwise correlational analyses. In each case, better performance on these tasks was associated with higher levels of fractional anisotropy in task-relevant regions.
Abstract 2531: Genomic landscape of breast cancer patients in Korea: Early data from K-MASTER project
Authors: Jae Sook Sung, Hee-Joon Chung, Yoon Ji Choi, Won Jin Chang, Jung Yoon Choi, Ju Won Kim, Kyong Hwa Park, Yeul Hong Kim
Journal: Cancer Research (2019)

Abstract The K-MASTER cancer precision medicine diagnosis and treatment enterprise (K-MASTER project) is a precision medicine cancer treatment clinical trial platform, which uses NGS assay to screen the actionable mutations in 10,000 patients with refractory solid tumors and assigns the patients to matched treatment. K-MASTER project was initiated in Korea since June 2017. From October 2017, we have analyzed next-generation (NGS)-based cancer panel to detect cancer genomic variations in breast cancer. This study is ongoing with 36 sites. Tumor DNA was analyzed by CancerSCAN (Samsung Genomic Institute) which allows to detect variations of 375 genes. As of October 31 in 2018, total 164 breast cancer patients were submitted and 95 samples were analyzed. The failure rate of sequencing was 4.1% of patients with samples submitted. The mean depth of CancerSCAN was 701x. Average turn-around time (TAT) of CancerSCAN was 3 weeks.In Korean breast cancer patients, variations were mainly identified in TP53 (63.6%), PIK3CA (35.2%), BRCA1 (25.0%), BRCA2 (23.9%), ERBB2 (23.9%), PTCH1 (21.6%), NOTCH1 (19.3%), FGFR1 (12.5%), PTEN (11.4%) and MET (9.1%). Further analysis will confirm amplification and deletion in breast cancer. Until March 2019, we will finish the genomic profiling of 350 breast cancer patients and will be reported. In conclusion, this project is efficient to detect actionable variations in breast cancer. This novel knowledge provides an intriguing background to investigate new target approaches and to progress precision medicine. (This research was supported by a grant of the Korea Health Technology R&amp;D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health &amp;Welfare, Republic of Korea (Grant number: HI17C2206).) Citation Format: Jae Sook Sung, Hee-Joon Chung, Yoon Ji Choi, Won Jin Chang, Jung Yoon Choi, Ju Won Kim, Kyong Hwa Park, Yeul Hong Kim. Genomic landscape of breast cancer patients in Korea: Early data from K-MASTER project [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2531.
169P First-line FOLFOX-4 ± cetuximab in patients with RAS wild-type metastatic colorectal cancer: The open-label, randomized, phase 3 TAILOR trial
Authors: S. Qin, J. Xu, L. Wang, Y. Cheng, T. Liu, J. Chen, J. Liu, J. Li
Journal: Annals of Oncology (2016)
2. Classification and Diagnosis of Diabetes:<i>Standards of Medical Care in Diabetes—2020</i>
Journal: Diabetes Care (2019)

The American Diabetes Association (ADA) “Standards of Medical Care in Diabetes” includes the ADA’s current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA Professional Practice Committee (https://doi.org/10.2337/dc20-SPPC), a multidisciplinary expert committee, are responsible for updating the Standards of Care annually, or more frequently as warranted. For a detailed description of ADA standards, statements, and reports, as well as the evidence-grading system for ADA’s clinical practice recommendations, please refer to the Standards of Care Introduction (https://doi.org/10.2337/dc20-SINT). Readers who wish to comment on the Standards of Care are invited to do so at professional.diabetes.org/SOC.
Organ Recital
Authors: George N. Braman
Journal: Annals of Internal Medicine (2006)

Ad Libitum18 July 2006Organ RecitalGeorge N. BramanGeorge N. BramanFrom Bronx, NY 10471.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-145-2-200607180-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail No, it isn't Bach or BuxtehudeJust an anatomic euphemism,Or puppet show, intern's Punch and JudyOf “nutmeg liver” and aneurysm.No thundering cascade of vibrant sound,Although the audience is hushed and awed—He makes no bones about what clues he's foundTo prove the doctor's diagnosis flawed.And yet one can't help relishing the tonesAnd harmonies of Beethoven and Brahms;The dry voice of the pathologist dronesOf pancreas and spleen; he has no qualmsEmbellishing; I wish he'd played insteadMozart's solemn Requiem for the dead. Author, Article, and Disclosure InformationAffiliations: From Bronx, NY 10471.Current Author Address: George N. Braman, MD, 6142 Delafield Avenue, Bronx, NY 10471. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 18 July 2006Volume 145, Issue 2Page: 149KeywordsAneurysmsBoneLiverPancreasPathologistsSpleen ePublished: 18 July 2006 Issue Published: 18 July 2006 Copyright & PermissionsCopyright © 2006 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Vaginitis revisited.
Journal: BMJ (1981)

Vaginitis revisitedThe diagnosis and treatment of non-specific vaginitis arc, as its name suggests, unsatisfactory both microbiologically and clinically.Non-specific infcction is considcrably more common than trichomoniasis or candidiasis, but whether the unfor- tunate patients prcscnt to general practitioners, gynaecologists, or genitourinary physicians they are usually given ineffective treatmcnt.Many rcsort to non-medical measures, which range from douching and vaginal deodorants to the use of tampons, sometimes perfumed, in an attempt to control the discharge.Nearly 30 years ago Lcopold' isolated an organism from cervical swabs of women with "signs of cervicitis," from the urinc of men with "mild to moderate prostatitis," and also from the urine of the husbands of women with positive cervical cultures.Two years after these rcsults were published Gardner and Dukes2 assigned the name Haceophi/lis vaginalis to a bacillus cultured from 127 of 138 women with "bacterial vaginitis," and also from the urethras of 45 of 47 husbands of women infected with the organism.There seems little doubt that the two reports independently described the same organism.Gardner and Dukes2 noted that practically all their patients were conscious of a disagreeable odour from their discharge.They put considerable diagnostic emphasis on the presence of "clue cells"-vaginal epithelial cells covered with small Gram-negative rods-seen in wet mounts of the discharge.They even succeeded in establishing clinical infection in one of 13 "voluntecrs" inoculated with a pure culture of H
EDITORIAL.
Authors: None J. M. T.
Journal: JAMA (1884)

Gross, Samuel D., M.D., LL.D., of Philadelphia, was born near Easton, Northampton Co., Pa., July 8, 1805; died at his residence in Philadelphia, May 6, 1884. His literary and classical education was obtained at the Wilkesbarre Academy, and the high school, Lawrenceville, N. J. Having selected medicine as the pursuit of his life, he began the study of it in his native place with Dr. Joseph K. Swift, and subsequently for some two years he was a student in the office of Prof. George McClellan. After attending the usual course of lectures in the Jefferson Medical College, he received the degree of M.D. in 1828. Dr. Gross began practice in Philadelphia; he was fond of study, industrious, and stable in his purposes, and being resolved to succeed in his profession, occupied his spare time in extending his medical researches and in editing or translating medical papers and works from the
Dietary saturated fatty acids down-regulate cyclooxygenase-2 and tumor necrosis factor alfa and reverse fibrosis in alcohol-induced liver disease in the rat
Authors: A Nanji
Journal: Hepatology (1997)

We investigated the potential of dietary saturated fatty acids to decrease endotoxemia and suppress expression of cyclooxygenase 2 (Cox-2) and tumor necrosis factor α (TNF-α) in established alcohol-induced liver injury. Six groups (five rats/group) of male Wistar rats were studied. Rats in group 1 were fed a fish oil-ethanol diet for 6 weeks. Rats in groups 2, 3, and 4 were fed fish oil and ethanol for 6 weeks. Ethanol administration was stopped at this time, and the rats were switched to isocaloric diets containing dextrose with fish oil (group 2), palm oil (group 3), or medium-chain triglycerides (group 4) as the source of fat for an additional 2 weeks. Rats in groups 5 and 6 were fed fish oil-ethanol and fish oil-dextrose, respectively, for 8 weeks. Liver samples were analyzed for histopathology, lipid peroxidation, and levels of messenger RNA (mRNA) for Cox-2 and TNF-α. Concentrations of endotoxin were determined in plasma. The most severe inflammation and fibrosis were detected in groups 1 and 5, as were the highest levels of endotoxin, lipid peroxidation, and mRNA for Cox-2 and TNF-α. After ethanol was discontinued, there was minimal histological improvement in group 2 but near normalization of the histology, including regression of fibrosis, in groups 3 and 4. Histological improvement was associated with decreased levels of endotoxin, lipid peroxidation, and reduced expression of Cox-2 and TNF-α. The data indicate that a diet enriched in saturated fatty acids (groups 3 and 4) effectively reverses alcohol-induced liver injury, including fibrosis. The therapeutic effects of saturated fatty acids may be explained, at least in part, by reduced endotoxemia and lipid peroxidation, which in turn result in decreased levels of TNF-α and Cox-2.
Hematology
Authors: Carol K. Kasper
Journal: JAMA (1982)

<h3>The Hemophilias</h3> We have learned a great deal in the past decade about the molecular characteristics of factors VIII and IX. As a result, hemophilias A and B can be diagnosed in utero, tests for the carrier state are more accurate, and a few of the veils of mystery around von Willebrand's disease have parted. We also have become accustomed to the therapeutic advantages of concentrated clotting factor preparations. In children, attention is shifting from treatment to prevention. The accumulating population of hemophilic adults, who often have disabilities, is challenging the talents of orthopedic surgeons and social scientists. <h3>Care of Severe Hemophilia</h3> Great progress has been made in the management of severe hemophilia. Before blood banks were developed in the 1940s, three of every four patients with severe hemophilia died by the age of 15 years, most commonly of exsanguination from minor wounds.<sup>1</sup>Severe crippling arthritis was commonplace, as repeated
Noninvasive Methods for Measuring DNA Alkylation in Experimental Animals and Humans
Authors: David E. G. Shuker, Virginie Prevost, Marlin D. Friesen, Helmut Bartsch
Journal: Environmental Health Perspectives (1993)

Alkylpurines are liberated from alkylated DNA by glycosylase repair enzymes and, in most cases, excreted in urine without further metabolism.This phenomenon forms the basis of noninvasive methods to measure DNA alkylation in vivo.In the case of methyl adducts, such as 7-methylguanine (7-MeGua), natural backgrounds exist due to RNA turnover.However, deuterated (d3) methylating agents or precursors give rise to d3-7-MeGua and d3-3-methyladenine (3-MeAde), which can be readily quantitated using gas chromatography-mass spectrometry (GC-MS).A deuterated probe drug, such as d6-aminopyrine, can be used to measure endogenous nitrosation levels in experimental animals.In contrast, for higher alkyl homologues of alkylpurines, natural backgrounds are low or nonexistent and can be directly measured by GC-MS using stable isotope labeled internal standards.For example, increased levels of urinary 3-ethyladenine were observed in cigarette smokers.Due to recent advances in analytical methodology, notably immunoaffinity cleanup of urine, measurements of excreted DNA adducts can be used in studies in human populations exposed to low levels of alkylating carcinogens.