tbuckley/cabot-search huggingface dataset:
Response to measles, mumps, and rubella revaccination among HIV‐positive and HIV‐negative children and adolescents with hemophilia
Authors: Margaret W. Hilgartner, Margaret A. Maeder, Elizabeth M. Mahoney, Sharyne M. Donfield, Bruce L. Evatt, W. Keith Hoots
Journal: American Journal of Hematology (2001)

The effect of human immunodeficiency virus (HIV) infection on response to measles, mumps, and rubella revaccination in children and adolescents with hemophilia was evaluated. Antibody levels of measles, mumps, and rubella were assayed at baseline and two annual examinations in 207 HIV-positive and 126 HIV-negative hemophiliacs participating in the Hemophilia Growth and Development Study (HGDS). Response to revaccination was analyzed for participants whose antibody levels were below the cut-off at the start of a year-long observation period. Among HIV-positive participants, antibody levels were below cut-off in 52 subjects for measles, in 71 for mumps, and in 96 for rubella. Among HIV-negative participants, antibody levels were low in 23 subjects for measles, in 23 for mumps, and in 31 for rubella. For measles and mumps antigens, revaccination was associated with a significant increase in redraw antibody levels for HIV-negative participants. Although there was an increase in the mean measles titers for revaccinated HIV-positive participants, it was not significant. Revaccination was associated with an increase in rubella antibodies in HIV-positive and HIV-negative participants. Revaccination with measles and mumps was associated with an increase in antibody levels in HIV-negative participants but not in HIV-positive participants. Both HIV-positive and HIV-negative participants responded to rubella revaccination with an increase in antibody levels. Am. J. Hematol. 66:92–98, 2001. © 2001 Wiley-Liss, Inc.
Practical Application of Experimental Cancer Research
Authors: Charles L. Dunlap
Journal: JAMA (1971)

Advances in cancer research usually are not dramatic, and socalled breakthroughs results from accumulated knowledge gained from the contributions of many investigators over a period of time. Prodigious research has produced steady gains, but there has been no single discovery that is of universal benefit to all patients with cancer and there may never be. The reason is that cancer is not a single disease. Experimental carcinogenesis has not produced clinically applicable results. Methotrexate has been shown to enhance the cancer-producing effect of dimethylbenzanthracene in the buccal pouch of the hamster; one wonders about the patient who is receiving methotrexate therapeutically and has an occult dysplastic oral lesion. Busulfan has been reported to produce dysplasia in multiple organ systems, and one author<sup>33</sup>observed abnormal cellular changes in exfoliated oral mucosa cells in patients who were receiving a variety of chemotherapeutic drugs. Similarly, oral and upper respiratory tract neoplasms are
Erratum: APOE*4–associated Alzheimer's disease risk is modified by α1–antichymotrypsin polymorphism
Authors: Carla Rosenberg', Ralph Florijn', Frans Van De Rijke, Lau Blonden', Tonk Raap, Gert-Jan Van Ommen', M Kamboh', Dharambir Sanghera, Robert Ferrell', Steven Dekosky'
Journal: Nature Genetics (1995)
Book Review A Synopsis of Surgical Anatomy . By Alexander Lee McGregor, M.Ch. (Edin.), F.R.C.S. (Eng.), with a foreword by Sir Harold J. Stiles, K.B.E., F.R.C.S. (Edin.). Fourth edition. 12°, cloth, 664 pp., with 648 illustrations. Baltimore: William Wood &amp; Co., 1939. $6.00.
Journal: New England Journal of Medicine (1940)
ALLERGY
Authors: G. B. DOWLING, F.R.C.P LOND
Journal: British Journal of Dermatology (1936)

Journal Article ALLERGY Get access G. B. DOWLING, M.D., G. B. DOWLING, M.D. Search for other works by this author on: Oxford Academic Google Scholar F.R.C.P LOND F.R.C.P LOND Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 48, Issue 11, 1 November 1936, Pages 601–609, https://doi.org/10.1111/j.1365-2133.1936.tb10004.x Published: 01 November 1936
Abstract 15878: GSK-3α in Fibroblasts Attenuates Cardiac Fibrosis and Dysfunction Induced by Pressure Overload Through Modulation of TGFβ1
Authors: Peiyong Zhai, Akihiro Shirakabe, Bonaventure Magrys, Junichi Sadoshima
Journal: Circulation (2015)

Glycogen synthase kinase-3α (GSK-3α) is a ubiquitously expressed S/T kinase that has versatile functions. Cardiac-specific loss of GSK-3α has outcomes that contrast with those of systemic deletion of GSK-3α after myocardial infarction, indicating cell type-specific roles of GSK-3α. However, the role of GSK-3α in fibroblasts (FB) remains to be defined. We hypothesized that GSK-3α in FB attenuates cardiac fibrosis (CF) and dysfunction in response to pressure overload (PO), and subjected FB-specific GSK-3α knockout mice (GSK-3αf/f/FSP-Cre, KO) and littermate GSK-3αf/f mice (CT) to 4 weeks of PO induced by transverse aortic constriction. The CF (%) was greater in KO than in CT (1.9±0.2 vs 1.1±0.1, p&lt;0.01) after sham operation, showing that loss of GSK-3α in FB causes CF at baseline. After PO, CF was increased in both KO and CT, and there was much more in KO than in CT (7.9±1.3 vs 3.8±0.4, p&lt;0.01). There was significantly more type I and type III collagen in KO than in CT after PO. Cardiac FB (%) measured by positive HSP47 staining area was more in KO than in CT after PO (22±1 vs 11±1, p&lt;0.005). These data suggest that loss of GSK-3α in FB promotes CF. The lung weight/body weight (mg/g) was greater in KO than in CT (11.3±1.8 vs 7.7±0.7, p&lt;0.05) after PO, indicating that KO had more severe lung congestion. Left ventricular (LV) ejection fraction (EF) and fractional shortening (FS) were not significantly different between sham KO and CT. The EF (45±5% vs 58±3%, p&lt;0.05) and FS (19±2% vs 25±2%, p&lt;0.05) were lower in KO than in CT after PO. LV ±dP/dts (mmHg/s) were lower in KO than in CT after PO (+dP/dt, 5306±358 vs 7536±541, p&lt;0.01; -dP/dt, 6250±404 vs 8893±353, p&lt;0.001) although they were not significantly different between sham KO and CT. LV end-diastolic pressure was higher in KO than in CT (15±2 vs 9±2, p&lt;0.05) after PO. These data show that loss of GSK-3α in FB exacerbates PO-induced cardiac dysfunction. More TGFβ1 was observed in cardiac FB in KO than in CT after PO. In neonatal rat cardiac FB, knockdown of GSK-3α increased the levels of TGFβ1, phospho-Smad3, α-smooth muscle actin, and Ki67-positive cells, showing that GSK-3α inhibits proliferation and myofibroblast transformation of FB. In conclusion, GSK-3α in FB protects against PO-induced CF and dysfunction through inhibition of TGFβ1.
Adult immunization with acellular pertussis vaccine
Authors: K. M. Edwards
Journal: JAMA (1993)

<h3>Objective.</h3> —To evaluate the safety and immunogenicity in adults of several different concentrations of an acellular pertussis vaccine. <h3>Design.</h3> —Double-blind, randomized, placebo-controlled trial. <h3>Setting.</h3> —Medical center immunization clinic. <h3>Participants.</h3> —One hundred eighteen healthy adult volunteers. <h3>Interventions.</h3> —Participants received standard adult tetanus-diphtheria vaccine alone or combined with full-strength, half-strength, or quarter-strength concentrations of a currently licensed acellular pertussis vaccine used for booster doses in young children. Full-strength vaccine contained 40 μg of pertussis proteins, consisting of 86% filamentous hemagglutinin, 8% pertussis toxin, 4% 69-kd outer-membrane protein, and 2% agglutinogens. <h3>Main Outcome Measures.</h3> —Local and systemic reactions were assessed for 14 days after vaccination. Serum samples for antibody assay were obtained before, 1 month after, and 1 year after immunization. <h3>Results.</h3> —Adverse reactions were few and minor and did not differ in frequency or severity among the four study groups. The groups receiving acellular pertussis vaccine showed strong antibody responses to pertussis antigens, which did not significantly differ by concentration of vaccine. After 1 year, levels of antibody to pertussis had declined by approximately 50% but remained substantially higher than preimmunization levels. The four groups did not differ in antibody responses to tetanus or diphtheria toxoids. <h3>Conclusions.</h3> —Routine reimmunization of adults with a vaccine containing acellular pertussis antigens in addition to diphtheria and tetanus toxoids can substantially enhance pertussis antibody levels without an increase in adverse reactions or diminution in response to the diphtheria and tetanus components. Such a program might materially reduce respiratory illness among both adults and children. (<i>JAMA</i>. 1993;269:53-56)
"SMOKING VERSUS CHEWING"
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AUTHOR'S REPLY
Authors: R. Miller
Journal: Thorax (1989)

Nebulised pentamidine as treatment for Pneumocystis carinu pneumonia in the acquired immunodeficiency syndrome SIR,-Dr Miller and his colleagues (July 1989;44:565-9) report that nebulised pentamidine when delivered by a Respirgard II nebuliser is more effective in the treatment of Pneumocystis carinii pneumonia than when delivered by an Acorn nebuliser.They state, however, that the mass median aerodynamic diameter (MMAD) of the aerosol produced by the Acorn is 2-6 pm.This means that 50% ofthe aerosol mass is contained in droplets ofless than 2-6 pm and 50% of the aerosol mass is contained in droplets of 2-6 pm or more.It is therefore a physical impossibility for 46% of the particles to be less than 3 9 pm, as the authors state.If this latter figure is correct, then the MMAD of the aerosol must be 3 9 pm or more.The correct size of the aerosol is critical to the interpretation of this study.Newman and colleagues have shown that the MMAD of the Acorn nebuliser, when measured in the same manner, ranges from 4 5 to 5-7 pm.'It seems likely that Dr Miller and his colleagues have miscalculated the MMAD.Only one patient from the group treated by Acorn nebulisers was seen to have oozing and contact bleeding at bronchoscopy, whereas four patients from the Respirgard group, which delivers a smaller droplet aerosol, were noted to have these findings.It is therefore difficult to implicate the pentamidine as the cause of these abnormalities, as the larger aerosol (delivered by the Acorn nebuliser) would be expected to produce a greater upper airway deposition, and so cause more rather than less mucosal irritation.Moreover, the authors state that the diagnosis of pneumocystis pneumonia was made by bronchoscopy before pentamidine was started (with the exception of one patient treated empirically).How is it then possible for the nebulised pentamidine to have caused the mucosal friability attributed to it?
Queries and Minor Notes
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medical Economics
Journal: JAMA (1910)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sliding-Associated Injuries in College and Professional Baseball—1990-11991
Journal: JAMA (1993)

Softball and baseball are among the most frequent causes of sports-related emergency department visits in the United States, accounting for an estimated 321,000 injuries in 1989. Approximately 71% of softball-related injuries are caused by sliding. The use of breakaway bases substantially decreases the risk for or occurrence of sliding-related injuries among recreational softball league players. This report summarizes the findings of a study on the impact of breakaway base use on sliding injuries among college and professional minor league baseball players.
AMAGRAMS
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Outcome prediction for patients with cirrhosis of the liver in a medical ICU: a comparison of the APACHE scores and liver-specific scoringsystems
Authors: C. A. Zauner, R. C. Apsner, A. Kranz, L. Kramer, C. Madl, B. Schneider, B. Schneeweiss, K. Ratheiser, F. Stockenhuber, K. Lenz
Journal: Intensive Care Medicine (1996)
Acute Hemorrhagic Conjunctivitis--St Croix, US Virgin Islands, September-October 1998
Journal: JAMA (1998)

Hurricane Georges struck the U.S. Virgin Islands on September 21, 1998. Immediately thereafter, health authorities on St. Croix (1998 population: approximately 50,000) became aware of increased numbers of cases of conjunctivitis. During September, one of the two public health clinics on the island recorded 88 cases of conjunctivitis, compared with three cases during August. Cases were characterized by periorbital swelling, excessive lacrimation, conjunctival redness with occasional hemorrhages, and foreign-body sensation in the eye. No severe sequelae were reported. Local ophthalmologists considered the symptoms characteristic of viral acute hemorrhagic conjunctivitis (AHC). This report describes the initial findings of an ongoing clinical, epidemiologic, and laboratory investigation of this outbreak.
GOITER PROPHYLAXIS WHERE THE INCIDENCE OF GOITER IS LOW
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A 38 year old woman with hypotensive shock at the onset of menstruation: case progression
Authors: S. Serrano Villar, J. Perez-Somarriba, T. Sainz Costa, S. Winstanley, T. Santillana Lopez, L. Escribano Mora, B. Orejas Gonzalez
Journal: BMJ (2009)

<h3>Background</h3> Cellulitis can sometimes be challenging for healthcare professionals to diagnose, with no validated diagnostic criteria available. Supporting healthcare professionals to make a more accurate diagnosis of cellulitis in different groups, such as those with lymphoedema, is a cellulitis research priority. However, to the authors knowledge, no previous studies have looked at the involvement of non-healthcare professionals in the diagnostic process. <h3>Aim</h3> To explore the experience of people with lymphoedema and recurrent cellulitis in the diagnosis of lower-limb cellulitis. <h3>Design and setting</h3> Single, semi-structured, qualitative interviews carried out between 29 October and 19 December 2018. <h3>Method</h3> Adults with a suspected episode of cellulitis who had been diagnosed in the last 12 months or had a history of recurrent cellulitis were interviewed. <h3>Results</h3> Three key themes emerged: the recurrent nature of cellulitis symptoms, participants’ experience of getting a cellulitis diagnosis, and participants’ suggestions of how cellulitis diagnosis might be improved. Generally, people with lymphoedema experienced similar clinical features during each of their own recurrent cellulitis episodes and were confident that they could make a self-diagnosis of cellulitis. This is also reflected in the participants’ perceived trust from the healthcare professional in being able to make a self-diagnosis. A diagnostic checklist and educational resources were suggested as methods to improve diagnosis. <h3>Conclusion</h3> Selected people with lymphoedema who have recurrent cellulitis are confident in self-diagnosing their own recurrent cellulitis episodes. There may be a role for greater involvement of people with lymphoedema in their cellulitis diagnosis.
ORAL MANIFESTATIONS AND ALLIED STATES.
Authors: E. S. TALBOT
Journal: JAMA (1901)

Scurvy is a disease characterized by simple inflammation of the gums which gradually becomes chronic and deep-seated, and extends throughout the alveolar process causing its absorption and exfoliation of the teeth. This disease has passed under various designations: salivation, bromidism, plumbism, iodism, pyorrhea alveolaris, phagadenic pericementis, ptyalism and interstitial gingivitis. These terms merely define local manifestations in connection with other symptoms. The term interstitial gingivitis defines the precise pathologic change which occurs in the tissues. Pathologic material for the study of scurvy in man is obtained with such difficulty in the recent state as to necessitate research upon animals. As the first step in investigation, two practitioners of comparative medicine, with an extensive hospital practice, were consulted as to the frequency of this disease in animals. All animals under their care suffered from it more or less, but 80 per cent. of dogs over 8 years of age had the
Commentaire de travail de C. Katada et al., pp. 779
Journal: Endoscopy (2007)

See also: Clinical outcome after endoscopic mucosal resection for esophageal squamous cell carcinoma invading the muscularis mucosae - a multicenter retrospective cohort studyEndoscopy 2007; 39(09): 779-783DOI: 10.1055/s-2007-966761