tbuckley/cabot-search huggingface dataset:
Electrolyte solution in surgical patients refusing transfusion
Authors: S. Gollub
Journal: JAMA (1971)

Major blood loss in 13 surgical patients was treated by infusion of crystalloid solution alone, supplemented by colloid plasma expander when necessary. Neither whole blood nor any of its components or fractions was employed at any time. For losses of 21% to 66% of blood volume, Ringer's solution, administered in three to five times the volume of blood loss, produced physiologically significant intravascular fluid increments equalling one fifth to three fifths of the shed blood. Colloid solutions were required to sustain blood volumes or blood pressure for patients with blood losses in excess of 1,200 ml, otherwise clinically significant edema was manifested. One week after surgery, blood volumes averaged 90% of original values. The death rate was three thirteenths. The average hospital stay was prolonged 3.4 days.
CDC’s Historic Response to Ebola
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Transplacental Passage of Antinuclear Antibody
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
La angina de pecho.
Journal: JAMA (1933)

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Percutaneous transhepatic biliary drainage. Results and complications in 81 patients
Authors: P. K. Joseph
Journal: JAMA (1986)

Percutaneous transhepatic biliary drainage is usually used for preoperative decompression and for palliation in obstructive jaundice, but little attention has been focused on catheter complications. We retrospectively reviewed our experience with percutaneous transhepatic biliary drainage in 81 consecutive patients. There was a 10.0% failure rate and an 8.6% mortality rate. Four patients (4.9%) required emergency operations for complications and an additional ten patients (12.3%) required transfusions. The overall sepsis rate was 34.6%; prophylactic antibiotics decreased the sepsis rate. Thirty-eight patients (47.0%) required 68 manipulation procedures for catheter malfunctions. No distinguishing characteristics could be found to identify the subgroups having complications or mortalities. The efficacy of preoperative percutaneous transhepatic biliary drainage has not been proved, and the indications for palliation are not clearly defined. Further trials are needed to define the role of percutaneous transhepatic biliary drainage in patients with obstructive jaundice. (<i>JAMA</i>1986;255:2763-2767)
A POSSIBLE LEGAL DISTINCTION.
Journal: JAMA (1903)

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UNWISE ATTEMPTS AT CLIMATIC TREATMENT OF TUBERCULOSIS.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Status of antiplatelet drugs in coronary heart disease
Authors: J. Mehta
Journal: JAMA (1979)

A RECENT report suggesting prevention of cardiac death after myocardial infarction in patients given sulfinpyrazone<sup>1</sup>has renewed interest in antiplatelet drugs within the medical profession. During the last few years, it has become clear that blood platelets are involved in arterial and venous obstruction and in the origin of smooth-muscle hypertrophy and possibly atherogenesis. If altered platelet function is related to the pathogenesis of coronary disease and subsequent cardiovascular mortality and morbidity, the use of antiplatelet drugs in patients with coronary heart disease would be rationalized. Our purpose is to review information on the role of platelets in coronary artery disease and to show how antiplatelet drugs might affect platelet function and thereby influence coronary vascular disease. <h3>Role of Platelet Function in Coronary Artery Disease</h3> In animal models of myocardial ischemia induced by experimental coronary narrowing, platelet aggregates appear within a short time in coronary vessels.<sup>2,3</sup>These aggregates
In This Issue
Authors: Ruth Williams
Journal: Circulation Research (2020)

Genetics of Transposition of the Great Arteries (p 811) Liu et al discover genetic links between cilia function and a common congenital heart defect.In normal healthy hearts, the aorta and pulmonary arteries arise from the left and right ventricles, respectively.But in transposition of the great arteries (TGA), a common developmental heart malformation, the plumbing of these two major vessels is switched.The genetic etiology of this life-threatening condition, which requires surgery in the early days of life, is largely unknown.Liu and colleagues thus examined the whole-exome sequences of 249 TGA patients and, in 66 cases, their parents in the hopes of finding genetic clues.The analysis yielded 82 candidate genes, in which variants or mutations present in TGA patients were likely to alter protein function.And, of these, almost a quarter (19) were involved in cilia function.TGA has been hypothesized to arise from disturbances in left-right patterning during embryo development.And cilia are essential for left-right axis determination-through their control of morphogen flow, among other things.Cilia genes have also been implicated in some other congenital heart malformations.The findings of Liu and colleagues not only provide insights into the etiology of this hitherto mysterious malformation, but may also inform future prenatal diagnostic tests for the condition, say the authors.
AMERICAN MEDICAL ASSOCIATION.Proceedings of the Fifty-fifth Annual Session, held al Atlantic City, N. J., June 7-10, 1904.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
长期日晒与组蛋白乙酰化变化有关
Authors: S. Ding, J. Chen, Q. Zeng, J. Lu, L. Tan, A. Guo, J. Kang, S. Yang, Y. Xiang, C. Zuo, J. Huang
Journal: British Journal of Dermatology (2018)

光老化是由阳光或人工紫外线照射(例如日晒床)引起的皮肤过早老化。它几乎影响着世界上的每个人。组蛋白是带正电荷的蛋白,因此可与带负电荷的DNA结合。某些组蛋白像线轴一样,被线状DNA所环绕。本研究在中国开展,旨在分析可调控日晒和非日晒皮肤中基因表达的组蛋白的变化(修饰)模式,并识别异常组蛋白修饰的光老化相关基因。我们通过ELISA(利用抗体和颜色变化来识别物质的测试)测试了日晒和非日晒皮肤样本的组蛋白修饰概况,发现日晒皮肤样本中的组蛋白H3乙酰化(一类组蛋白修饰)与非日晒皮肤样本相比明显增加。日晒皮肤中的P300表达增加以及HDAC1和SIRT1表达减少可能是主要原因(P300、HDAC1和SIRT1是与组蛋白修饰相关的酶)。此外,我们还通过测试对日晒和非日晒皮肤样本中组蛋白H3乙酰化发生了变化的基因进行了筛选。我们在日晒与非日晒皮肤样本中分别发现,227个基因中的组蛋白H3表现出明显的高度乙酰化(简单而言,即过度修饰),81个基因中的组蛋白H3表现出明显的乙酰化低下(修饰不足)。总而言之,长期日晒引起的组蛋白H3高度乙酰化可能在皮肤光老化中发挥重要作用。
THE PREVENTION OF DIPHTHERIA.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE SWEAT GLANDS
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reply
Authors: Kusumam Joseph, Rosemeire N. Constantino-Silva, Anete S. Grumach, Anna Feldweg, Lakiea Wright, Natasha Frank, Dana Vuzman, Rohit Sharma, Chiara Suffritti, Marco Cicardi, Lilian Varga, Henriette Farkas, Konrad Bork, Allen P. Kaplan
Journal: Journal of Allergy and Clinical Immunology (2017)
Section 43.—Chondrocalcinosis and Pseudogout
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An Open-Label Phase II Study of Buparlisib (BKM120) in Patients with Relapsed and Refractory Diffuse Large B-Cell Lymphoma (DLBCL), Mantle Cell Lymphoma (MCL) and Follicular Lymphoma (FL)
Authors: Anas Younes, Gilles Salles, Giovanni Martinelli, R. Gregory Bociek, Dolores Caballero Barrigon, Eva Gonzalez Barca, Mehmet Turgut, John F. Gerecitano, Fabian Herbst, Lisa Williams, Nabanita Mukherjee, Ranjana Tavorath, Won Seog Kim
Journal: Blood (2015)
Liver preservation: The past and the future
Authors: J Blankensteijn
Journal: Hepatology (1991)

The ultimate objective of organ preservation is unrestricted and immediate graft function after a transplant under optimal conditions in the most suitable recipient.This means that time and efficacy are the basic features of the search for the ideal preservation method.Theoretically, freezing and continuous aerobic perfusion are the only means of obtaining truly long-term preservation (from a month to years).From a clinical point of view, however, the preferred method of preserving livers for brief periods before transplantation is simple cold storage (1).Until recently, cold storage of the graft in Collins' solution provided acceptable graft function when preservation time was 8 hr or less (2).Still, in the first report of the European Liver Transplant Registry (31, reviewing 1,315 liver transplantations performed at 32 different centers from 1968 to 1987, one of the principal causes of loss of the graft (and occasionally of death of the patient) appeared to be the so-called "primary nonfunction" of the liver.In most cases this was thought to be through an injury caused by inadequate preservation.To keep the period of cold storage to a minimum, close coordination of two full surgical teams -one for the donor and one for the recipientwas necessary, and the recipient operation had to be performed as an emergency procedure, often at night.Furthermore, only a very narrow margin of safety existed in the storage time, in case of unforeseen delays or unanticipated, timeconsuming difficulty in the recipient operation.To evaluate the possibility of liver transplantation on a (semi-) elective basis, Belzer (4) looked at the clinical needs for preservation times and concluded that 12 to 18 hr was necessary for liver transplantation to be performed electively.Similar to kidney transplantation, (semi-) elective liver transplantation will yield substantial benefits: because simultaneous donor and recipient operations are not required, an unnecessary recipient laparotomy may be prevented if the donor organ appears unsuitable for transplantation.Furthermore, if laparotomy findings indicate that the recipient is unsuitable for
Nonequality of Brand Name Thyroxine Preparations
Authors: Angelita Ramos-Gabatin
Journal: JAMA (1980)

<h3>To the Editor.—</h3> Despite widespread use of oral sodium levothyroxine preparations, there are few data available comparing efficacy of different brand name oral preparations. We studied ultimate bioavailability of thyroid hormone in two preparations, Letter and Synthroid 100-μg thyroxine tablets. Ten patients (three men and seven women) requiring treatment with thyroid hormone volunteered for the study. One had diffuse goiter, three had hypothyroidism, and six had thyroid nodules. Each was treated for one month with an appropriate dose of Letter (lot No. 7913416) dispensed as the 100-μg tablet and then for a second month with a numerically equivalent dose of Synthroid (lot No. ZD1678) dispensed as the 100-μg tablet. After each treatment interval, blood was drawn for determination of the serum thyroxine (T<sub>4</sub>) level (normal, 5.5 to 12.0 μg/dL),<sup>1</sup>serum triiodothyronine (T<sub>3</sub>) level (normal, 84 to 220 ng/dL),<sup>2</sup>triiodothyronine resin uptake (RT<sub>3</sub>U) (normal, 25%
Abstract P210: Risk Factors for Intraparenchymal Hemorrhage Subtypes: The Circulatory Risk in Communities Study (CIRCS)
Authors: Tetsuya Ohira, Eri Eguchi, Hironori Imano, Akihiko Kitamura, Masahiko Kiyama, Kazumasa Yamagishi, Tomoko Sankai, Mitsumasa Umesawa, Renzhe Cui, Takeo Okada, Takeshi Tanigawa, Yoshinori Ishikawa, Hiroyasu Iso
Journal: Circulation (2013)

Background: To evaluate risk factors for intraparenchymal hemorrhage (IPH) by its subtypes may contribute to more effective prevention of IPH, but few prospective studies have characterized risk factors for specific subtypes of IPH. Hypothesis: We assessed the hypothesis that the associations between traditional risk factors such as blood pressures and risk of IPH vary by IPH subtype. Methods: A prospective study of Japanese subjects aged 40-69 years was undertaken using the data collected from 9,086 participants (3,560 men and 5,526 women) in cardiovascular risk surveys of three communities between 1985 and 1994. The incidence of IPH between 1985 and 2008 was ascertained by systematic surveillance. The location of hemorrhage was assigned based on admission CT scan or MRI by trained physicians. IPH selectively involving the thalamus, basal ganglia or brainstem was defined as deep IPH, while IPH isolated to the cortex was defined as lobar. The hazard ratios (HRs) of incidence of IPH and its subtypes (deep IPH and lobar or cerebellar IPH) and 95% confidence intervals (CI) relative to the baseline variables were calculated with adjustment for age and other potential confounding factors using the Cox proportional hazards model. Results: During an average follow up of 19.2-years, 139 incident IPHs (103 deep, 31 lobar or cerebellar, and 5 mixed or unclassified IPHs) occurred. Systolic blood pressure, major ST-T abnormality on electrocardiogram, and excess ethanol intake (≥46g/day) were associated with increased risk of deep IPH, while serum total cholesterol levels was inversely associated with incidence of lobar and cerebellar IPH, even after adjustment for potential confounding variables. Serum total cholesterol levels also tended to be inversely associated with incidence of deep IPH, although it did not reach statistically significance. The multivariate-adjusted HRs (95%CI) of deep IPH were 1.14 (1.05-1.23) for systolic blood pressure (10mmHg), 2.09 (1.19- 3.66) for major ST-T abnormality, and 1.86 (1.02- 3.38) for excess ethanol intake. The adjusted HR (95%CI) of lobar and cerebellar IPH was 0.22 (0.07- 0.76) for the participants with higher total cholesterol levels (≥220 mg/dL), compared with those with lower total cholesterol levels (&lt;160mg/dL). There were no associations of diabetes mellitus and smoking with both deep and lobar/cerebellar IPH. Conclusions: Impact of risk factors on incidence of IPH varied according to its subtype.