tbuckley/cabot-search huggingface dataset:
Notes for Contributors
Journal: Journal of the Royal Society of Medicine (1997)

The Journal is a benefit of membership of the Royal Society of Medicine and through it we aim to offer Fellows something stimulating or instructive or entertaining each month (preferably all three). It has also won a large readership outside the Society. As with medicine itself, the scope is almost limitless—from the clinical anecdote to the latest synthetic molecule, from health service politics to hermeneutics, from bronze age archaeology to art in hospitals. Our guiding principle is that good specialists read outside their specialty. Solemnity is not compulsory. For scientific work we offer a brisk review process, and can publish high-priority papers 6–8 weeks after acceptance, correspondence and meeting reports in as little as 3; thus, we attract good papers by offering an efficient service to authors. Our prime responsibility, however, is to the readers. If you are thinking of submitting a paper, please bear in mind that our readers come from the world over, from many specialties and some from none. Whereas in a specialist journal you may be writing for colleagues with shared knowledge (and jargon), in the JRSM you seek to engage wider attention. Do not be too proud to explain complexities; say why your message is important; and be brief. ~!~With these provisos, we welcome your contributions—whether original papers, reviews, opinion pieces, or whatever. If your article stems from a meeting of one of the Society's Sections or Forums, it should be submitted to Professor Tim David, Proceedings Editor, JRSM, Booth Hall Children's Hospital, Blackley, Manchester M9 7AA (Tel: 0161 220 5536; Fax: 0161 795 7542; E-mail: tim.david@dial.pipex.com ); on the title page please indicate when and where the meeting took place. All other items should be sent to Dr Robin Fox, Editor, JRSM, Royal Society of Medicine, 1 Wimpole Street, London W1M 8AE (Tel/Fax: 01892 853520; E-mail: 100674.1206@compuserve.com ). The following paragraphs offer hints on preparing and submitting material to the JRSM. Both of us stand ready to help at every stage in the genesis of an article, from the gleam in the eye to the final proofs. Call us or write.
Asthma nervosum
Authors: A. Papagiannis
Journal: European Respiratory Journal (2011)

To the Editors:The name ''asthma nervosa'' [1] is linguistically incorrect.Asthma is a Greek neutral noun in a language that tries hard to keep its genders apart.Nervosa is a Latin adjective and this language also does not mix the genders: nervosa is feminine (as are anorexia and bulimia, two conditions for which nervosa is appropriate).Therefore, we should refer to asthma as nervosum (both neutral).This may sound slightly odd in English, and therefore, I would have no objection to ''nervous asthma''.However, if we want to pay tribute to the Classics, we should try to use them as correctly as possible.
Induction of multidrug resistance gene expression during cholestasis in rats and nonhuman primates
Authors: D Schrenk
Journal: Hepatology (1993)

P-glycoprotein, an energy-dependent plasma membrane drug-efflux pump capable of reducing the intracellular concentration of a variety of hydrophobic xenobiotics, is encoded by mdr 1, a member of the multidrug-resistant (mdr) gene family. The physiological function of this protein is unknown. Because of its location on the bile canalicular domain of the hepatocyte, we and others have hypothesized that P-glycoprotein may have a physiological role as a biliary transporter of xenobiotics and endobiotics and that its expression may therefore be altered in cholestasis. Both obstructive and α-naphthylisothiocyanate-induced cholestasis increased mdr 1a and 1b gene expression in rat liver. Hepatic P-glycoprotein levels were also increased, and the protein remained localized at the biliary hepatocyte domain. Induction of mdr 1a and mdr 1b gene expression in rat liver was accomplished by means of increased transcription. α-Naphthylisothiocyanate-induced cholestasis in cynomolgus monkeys increased hepatic expression of both the mdr 1 and 2 genes. To investigate the possible role of P-glycoprotein as a biliary efflux transporter, biliary excretion of vinblastine, a representative substrate of P-glycoprotein, was studied in rats. Increased hepatic mdr messenger RNA and P-glycoprotein levels, mediated by the xenobiotic inducer 2-acetylaminofluorene, resulted in a significant increase in biliary excretion of vinblastine, which was antagonized by the P-glycoprotein inhibitor verapamil. These findings suggest that P-glycoprotein functions as a biiary efflux pump for xenobiotics and, possibly, for unidentified physiological inducers that may mediate increased transcription of the mdr gene observed during cholestasis. (HEPATOLOGY 1993;17:854–860.)
LONG-TERM OUTCOMES AFTER OUT-OF-HOSPITAL CARDIAC ARREST IN YOUNG PATIENTS WITH MYOCARDIAL INFARCTION
Authors: Ersilia M. Defilippis, Avinainder Singh, Bradley Collins, Ankur Gupta, Arman Qamar, Amber Fatima, Khurram Nasir, Marcelo Di Carli, Deepak Bhatt, Ron Blankstein
Journal: Journal of the American College of Cardiology (2018)
Regulation of hepatic transferrin, transferrin receptor and ferritin genes in human siderosis
Authors: A Pietrangelo
Journal: Hepatology (1991)

Although many studies have examined the regulation of transferrin, transferrin receptor and ferritin subunit gene expression in experimental systems, no molecular biological data in humans have been documented to date. In this study we simultaneously analyzed the hepatic content of transferrin, transferrin receptor and heavy and light ferritin subunit messenger RNAs in tissue samples obtained from subjects with normal iron balance and patients with primary or secondary iron overload. Steady-state levels of transferrin messenger RNA were not depressed by iron overload. On the contrary, they were increased (p < 0.001) in patients with severe hepatic siderosis (liver iron content > 200 μmol/gm dry wt) as compared with the control group. This indicates that, as already suggested by our previous data in experimental siderosis, iron maintains the ability to induce transferrin gene activity even when cellular iron content is significantly increased. Transferrin receptor gene expression was found to respond in the same manner to any cause of iron-tissue load, regardless of the cause. In fact, a lower signal for transferrin receptor messenger RNA was consistently detected in iron-overloaded patients vs. control subjects, particularly in patients with thalassemia major and idiopathic hemochromatosis (p < 0.001). Ferritin light-subunit messenger RNA accumulation was significantly increased in those patients with severe siderosis (idiopathic hemochromatosis and thalassemia major = liver iron between 200 and 600 μmol/gm dry wt). The fact that no significant change in hepatic ferritin heavy-subunit gene expression was detected in iron-loaded patients confirms preferential production of light-subunit–enriched ferritins in long-term iron overload. In addition, our data indicate that, in conditions where liver-specific abnormalities of iron-regulated proteins have been suggested (i.e., idiopathic hemochromatosis and sporadic porphyria cutanea tarda), the hepatic control of human iron metabolism, as inferred by the activity of transferrin, transferrin receptor and ferritin genes, is normal. (HEPATOLOGY 1991;14:1083–1089.)
Error in Author Name
Journal: JAMA Oncology (2020)

Veronica Mariotti, MD; Hyo Han, MD; Roohi Ismail-Khan, MD; Shou-Ching Tang, MD, PhD; Patrick Dillon, MD; Alberto J. Montero, MD; Andrew Poklepovic, MD; Susan Melin, MD; Nuhad K. Ibrahim, MD; Eugene Kennedy, MD; Nicholas Vahanian, MD; Charles Link, MD; Lucy Tennant, RN; Shelly Schuster; Chris Smith; Oana Danciu, MD; Paul Gilman, MD; Hatem Soliman, MD
Acute nonlymphocytic leukemia. An adult cluster
Authors: D. C. Bartsch
Journal: JAMA (1975)

Between 1970 and 1973, seven cases of acute nonlymphocytic leukemia were diagnosed in the village of Elmwood, Wis, and the surrounding area. The patients ranged in age from 14 to 97 years. Interpersonal relationships were noted among all patients in the group. This cluster of cases represents a greater than 20-fold increase in the expected incidence of this disease for this population. Morphologic similarities in the blast cells were seen in all cases. This cluster of cases may bear a relationship to bovine leukemia since the town was located in dairy farming country and because a number of the patients had either worked at or lived near the town creamery. (<i>JAMA</i>232:1333-1336, 1975)
Activity of a Heptad of Transcription Factors Is Associated with Stem Cell Programs and Clinical Outcome in Acute Myeloid Leukaemia
Authors: Eva Diffner, Dominik Beck, Emma Gudgin, Julie Thoms, Kathy Knezevic, Clare Pridans, Sam Foster, Debbie Goode, Wheng Khong Lim, Lies Boelen, Klaus H. Metzeler, Gos Micklem, Stefan K Bohlander, Christian Buske, Alan K Burnett, Katrin Ottersbach, George Vassiliou, Jake Olivier, Jason WH Wong, Berthold Gottgens, Brian Huntly, John E Pimanda
Journal: Blood (2012)
Medical News.
Journal: JAMA (1901)

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Pathogenesis of Mitral Regurgitation in Tachycardia-Induced Cardiomyopathy
Authors: Tomasz A. Timek, Paul Dagum, David T. Lai, David Liang, George T. Daughters, Neil B. Ingels, D. Craig Miller
Journal: Circulation (2001)

Background Dilated cardiomyopathy is often associated with mitral regurgitation (MR), or so-called functional MR, the mechanism of which continues to be debated. We studied the valvular and ventricular 3D geometric perturbations associated with MR in an ovine model of tachycardia-induced cardiomyopathy (TIC). Methods and Results Nine sheep underwent myocardial marker implantation in the left ventricle (LV), mitral annulus, and mitral leaflets. After 5 to 8 days, the animals were studied with biplane videofluoroscopy (baseline), and mitral competence was assessed by transesophageal echocardiography. Rapid ventricular pacing (180 to 230 bpm) was subsequently initiated for 15±6 days until the development of TIC and MR, whereupon biplane videofluoroscopy and transesophageal echocardiography studies were repeated. LV volume was calculated from the epicardial marker array. Valve closure time was defined as the time after end diastole when the distance between leaflet edge markers reached its minimal plateau. TIC resulted in increased LV end-diastolic volume ( P =0.001) and LV end-systolic volume ( P =0.0001) and greater LV sphericity ( P =0.02). MR increased significantly (grade 0.2±0.3 versus 2.2±0.9, P =0.0001), as did mitral annulus area (817±146 versus 1100±161 mm 2 , P =0.0001) and mitral annulus septal-lateral diameter (28.2±3.5 versus 35.1±2.6 mm, P =0.0001). Time of valve closure (70±18 versus 87±14 ms, P =0.23) and angular displacement of both the anterior (29±5° versus 27±3°, P =0.3) and posterior (55±15° versus 44±11°, P =0.13) leaflet edges relative to the mitral annulus after valve closure did not change, but leaflet edge separation after closure increased (5.2±0.9 versus 6.8±1.2 mm, P =0.019). Conclusions MR in TIC resulted from decreased leaflet coaptation secondary to annular dilatation in the septal-lateral direction. These data support the use of annular reduction procedures, such as rigid, complete ring annuloplasty, to address functional MR in patients with dilated cardiomyopathy.
Editorial Board
Authors: Massimo Co, Roberto De Franchis, Mario Mondelli, U David, Italy Domenico, Usa Paul, Marco Arrese, Chile Baumert, Germany Thomas, Jordi Bruix, Spain Buti, Spain Maria, Ding-Shinn Chen, Taiwan Craxı, Italy De Man, Robert The, Netherlands Dufour, Switzerland Esteban, Spain Rafael, Austria Peter, Spain Xavier, Garcia-Tsao Friedman, Usa Gerd, Germany Pape, Spain Gores, Usa Gregory, Austria Graziadei, Switzerland Hayashi, Japan Norio, Jenny Heathcote, Canada Heim, Switzerland Jacobson, Usa Jones, E Anthony, Netherlands Kadry, Usa Kaneko, Japan Shuichi, Saul Karpen, Usa Keeffe, Usa Koziel, Usa Kra ¨henbu ¨hl, Switzerland Kullak-Ublick, Hanns-Ulrich Marschall, Sweden Mazzaferro, Italy Mieli-Vergani, U Giorgina, Japan Tatsuo, Ricardo Moreno-Otero, Spain Moshage, Michael Nathanson, Usa Neuberger, U James, Germany Peter, Japan Kiwamu, Ronald Elferink, Netherlands Okanoue, Japan Takeshi, Jean-Michel Pawlotsky, France Petersen, Jo ¨rg
Journal: Journal of Hepatology (2005)
A novel approach to the temporary control of intractable bone pain
Authors: J. I. Zweig
Journal: JAMA (1980)

When treating patients with intractable bone pain secondary to bone metastasis from cancer, we have found that the injection of 2% lidocaine directly into the metastatic bone lesion will give prompt pain relief to some patients. Those who respond will then get prolonged pain relief lasting from 24 to 72 hours when reinjected with a mixture of 2% lidocaine and penicillin G procaine, 600,000 unitsμL. Lesions of the spine should not be treated with this method. (<i>JAMA</i>244:2445, 1980)
HEMOGLOBINURIA AFTER A SECOND TRANSFUSION WITH THE SAME DONOR
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Boost and Loss Of Immune Responses Against Tumor-Associated Antigens In The Course Of Pregnancy As a Model For Immunotherapy
Authors: Mathias Lutz, Medical Student, Miriam Alb, Andrea Worschech, Sabine Gahn, Laura Bernhard, Michael Schwab, Hermann Einsele, Ulrike Kämmerer, Peter Heuschmann, Erdwine Klinker, Christoph Otto, Stephan Mielke
Journal: Blood (2013)
Meet the First Authors
Authors: Felice Achilli
Journal: Circulation Research (2019)

Besides his clinical duties, Dr Achilli has been actively involved in cardiovascular epidemiology research, collaborating in the MONICA Project of the W.H.O.He has focused on acute cardiac care, acute and chronic heart failure, postinfarction ventricular remodeling and, in recent years, regenerative cardiovascular therapy.He has served as the PI on several independent clinical trials, such as STEM-AMI, RECARDIO, and the STEMAMI OUTCOME trial.Along with his professional commitments, Dr Achilli has developed a deep interest in the humanistic implications of the medical profession.He is the founder and National President of an Association of caregivers in the health sector, "Medicine and the Person."The Association is active in Italy and in several other countries.
<i>The Genesis and Dissolution of the Faculty of Speech.</i>By Joseph Collins, M. D., Prof. of Diseases of the Mind and Nervous System in the New York Post-Graduate Medical School; Neurologist to the New York City Hospital; to the St. John's Guild Free Hospital for Children, and to the Post-Graduate Hospital; Attending Physician to the St. Mark's Hospital. The Macmillan Co. 1898
Journal: American Journal of Psychiatry (1898)
Pity the FDA
Journal: JAMA (1973)

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BIRDS AND NAVIGATION
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Self-Cure of Consumption Without Medicine, with a Chapter on the Prevention of Consumption and Other Diseases.
Journal: JAMA (1904)

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Another consequence of uncontrolled spread of HIV among adults: vertical transmission
Authors: J. W. Zylke
Journal: JAMA (1991)

SOME mothers stitch baby blankets in celebration of their babies' birth. But the quilts adorning the walls at this conference were sewn to commemorate a child's death. Most children infected with the human immunodeficiency virus (HIV), such as those who are remembered in the panels from the NAMES (not an acronym) project displayed at the Sixth Annual National Pediatric AIDS Conference, at Washington, DC, were infected perinatally. The vertical transmission of HIV presents unique challenges to researchers and clinicians, yet its prevention ultimately depends on control of the disease in adults. <h3>Two Pediatric Patterns</h3> The route of transmission is obviously a major difference between the acquired immunodeficiency syndrome (AIDS) found in children and adults, but the clinical manifestations are different as well. Two patterns of disease occur in children. Some develop severe symptoms in the first year of life, such as wasting and encephalopathy.<i>Pneumocystis carinii</i>pneumonia is a major
Friedrich Trendelenburg (1844-1924) Trendelenburg's Position
Journal: JAMA (1969)

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