tbuckley/cabot-search huggingface dataset:
Specificity of the FTA-ABS test for syphilis
Authors: D. M. Mackey
Journal: JAMA (1969)

In this evaluation of the fluorescent treponemal antibody-absorption (FTA-ABS) test, special emphasis is placed on its specificity as opposed to sensitivity. Among a total of 827 persons tested, there were five with a reactive FTAABS test confirmed by the Control Laboratory, and a non-reactive<i>Treponema pallidum</i>immobilization test accompanied by no clinical or historical evidence of syphilis. These five persons represent 0.6% of the total tested and 1.4% of those with a reactive FTA-ABS test. Three of these patients had diseases in which abnormal globulins frequently are found—rheumatoid arthritis, autoimmune hemolytic anemia due to lymphosarcoma, and alcoholic cirrhosis; two had no recorded evidence of disease. All were more than 50 years of age. Whether these cases represent old syphilis or false positive reactions to the FTA-ABS test is problematical.
Hepatitis-associated antigen in blood donor populations. Relationship to posttransfusion hepatitis
Authors: H. F. Taswell
Journal: JAMA (1970)

Blood-donor serum samples from five medical centers, tested for hepatitis-associated antigen (HAA), showed widely varying incidence (0.06% to 1.47%). The incidence of HAA in the donor population correlated excellently with that of overt posttransfusion hepatitis. The sensitivity of the agar-gel immunodiffusion test was evaluated by study of the serum of 92 blood donors highly implicated in the transmission of hepatitis. Seventeen percent of these implicated donors were found to be HAA-positive, compared to 0.2% of 13,049 normal donors.
Cage allocation designs for rodent carcinogenicity experiments.
Authors: A M Herzberg, S W Lagakos
Journal: Environmental Health Perspectives (1992)

Cage allocation designs for rodent carcinogenicity experiments are discussed and presented with the goal of avoiding dosage group biases related to cage location. Considerations in selecting a cage design are first discussed in general terms. Specific designs are presented for use in experiments involving three, four, and five dose groups and with one, four, and five rodents per cage. Priorities for balancing treatment groups include horizontal position on shelf and shelf of rack, nearest neighbor balance, and male-female balance. It is proposed that these balance criteria be considered together with practical issues, such as the ability to accurately conform to a design and to determine a sensible and efficient design for each experiment.
Effect of Portacaval Shunting on Gastric Secretion in Cirrhotic Dogs
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Editorial: Progress in medical writing (or the lack of it)
Authors: H. H. Hussey
Journal: JAMA (1975)

If you are not in the habit of reading "JAMA 75 Years Ago," or if you failed to find the item in the July 21, 1975, issue because it was tucked away on page 235 at the end of "Reference Directories," seek it out, especially if you are interested in writing something for publication in one of AMA's scientific journals. The item consisted of an editorial published in<i>JAMA</i>on pages 164 and 165 precisely 75 years earlier. At that time, the medical centers in parts of Europe and the British Isles, with few exceptions, far outshone those in the United States. It was customary for US physicians who aspired to clinical excellence to travel abroad for postgraduate education. If they went to the right places and stayed long enough (and many of them did both), they returned to this country greatly enriched by their experience. Since treatment of diseases
Döhle Bodies and Other Granulocytic Alterations During Chemotherapy with Cyclophosphamide
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hyperbaric Medicine
Authors: S. A. Franzblau
Journal: JAMA (1967)

Among the approximately 130 papers presented, the topics range from experiments on cellular enzyme and organelle responses to gross clinical "die or recover" types of observation. An attempt was made to group the presentations into those dealing with the basic science aspects and the clinical subdivisions of various sorts; but, with much overlap, such categorization was of necessity rough. The reader gets the impression that anyone who had anything at all to present was given the opportunity to do so. Such an open forum may be desirable in so new a field, but before long some preliminary screening will be necessary to conserve the audience's time and patience. The present volume of proceedings (and this is only the third such conference) already runs to almost 800 pages. Workers in this field will need this volume. Others will find many items of interest. Future clinical applications of hyperbaric oxygen therapy appear
Lymphocytic Transformation
Authors: N. R. Ling, J. F. Soothill
Journal: BMJ (1964)

Rule of Three" SIR,-Some official rebuke from the B.M.A. should surely be made to the Minister of Transport in his recommendation that three drinks should be taken before driving at Christmas.His "rule of three" must surely be the most imprudent advice given to motorists for many a decade.The rule of "none for the road" should always apply.-I am, etc., lo0n1(101 W.1. Guy
Seeing you through London 2012: eye care at the Olympics
Authors: Penny J D'Ath, W David Thomson, Clare M Wilson
Journal: British Journal of Sports Medicine (2013)

Provision of eye care services for competitors and their support teams has become an integral part of the modern Olympic Games.To describe the organisation of the eye clinic at London 2012 over a 4-week period and provide outline audit data.The clinic employed multidisciplinary eye care professionals and utilised state-of-the-art instrumentation to provide the highest level of eye care.A total of 1406 patients from 154 countries attended the clinic over the Olympic Games, of which, 276 were competitors. All individuals received a comprehensive refractive and ocular health examination. Minor ocular injuries, glaucoma, diabetic retinopathy and macular degeneration were among the conditions detected and managed. Most patients attended the clinic to have their refractive status checked: 973 spectacles and 50 pairs of contact lenses were dispensed.It is hoped that this account of the provision of eye care at London 2012 will assist with the planning of this service at future events.
Spread of colds.
Journal: BMJ (1965)

MEDICAIL JOURNAL 14 but the patient died from uraemia on the 17th day.Necropsy showed resolving pancreatitis and chronic glomerulonephritis.The third patient, a 40-year-old woman with acute relapsing pancreatitis, was dialysed with a blood-urea level before dialysis of only 50 mg.per 100 ml.Her condition improved dramatically several hours after starting dialysis.This improvement was considered to be due to the washing out during dialysis of the enzymes irritating the peritoneal cavity.Subsequently, dialysis has been continued in all patients until the serum-amylase level has fallen to within normal limits.Though operative lavage is now contraindicated in acute pancreatitis, it seems justified to attempt peritoneal dialysis, provided this can be performed under good conditions.Bacterial peritonitis improves with peritoneal ravage,9 and in experienced centres using a fluid for dialysis that contains acetate and a closed cycling system infection due to peritoneal dialysis is extremely rare.In inexperienced hands, on the other hand, peritoneal dialysis remains extremely dangerous, and it often produces severe peritoneal infection or haemorrhage.Hence the widespread use of peritoneal dialysis for acute pancreatitis in a general surgical ward cannot be safely advocated, though it should be considered in specialist units.
Antibiotiki, Moscow
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Inflammatory and Toxic Diseases of Bone: A Text-Book for Senior Students.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Closing the Chapter on Maharishi Ayur-Veda
Authors: Deepak Chopra
Journal: JAMA (1992)

<h3>To the Editor.</h3> —With the October 2, 1991, publication of your attack against Maharishi Ayur-Veda,<sup>1</sup><i>JAMA's</i>readers have been presented with two diametrically opposed views of our activities: In the May 22/29, 1991, article co-authored by me,<sup>2</sup>Maharishi Ayur-Veda is portrayed as a serious attempt to bring a respected system of traditional Indian medicine to the West. This effort is backed by credentialed physicians who wish to explore a viable health care alternative. No outlandish claims are made for the efficacy of Maharishi Ayur-Veda. We present sound scientific research to support our hope that promising new therapies are being uncovered. In stark contrast,<i>JAMA's</i>subsequent attack portrays a cult that uses deceptive practices to further its dubious ends. I and my colleagues are made out to be quacks and unprincipled agents of a conspiracy to "infiltrate" prestigious journals with our superstitious nonsense. It is further alleged that our approach
Concurrent Care
Journal: Diabetes Care (1992)

Concurrent Care Diabetes mellitus is a disease that requires frequent medical attention.The hospitalization of a per-son with diabetes for an incurrent illness mandates ongoing medical evaluation and treatment of the diabetic state.Such close attention is best performed by a physician with special interest and expertise in diabetes.Thus, quality care for the hospitalized patient with diabetes usually requires concurrent care by a physician expert in diabetes and by a physician responsible for the patient's intercurrent illness.
Massive hemoperitoneum due to gastric diverticulum
Authors: W. W. Ward
Journal: JAMA (1966)

DIVERTICULUM of the stomach is an unusual anomaly of the upper gastrointestinal tract. A true diverticulum must contain all coats of the gastric wall with no evidence of other gastric or extragastric disease to account for it. The occurrence of this condition in only 0.0043% of general hospital admissions and 0.043% of routine radiologic studies emphasizes its rarity.<sup>1</sup>Palmer<sup>2</sup>reviewed 412 authentic cases reported by 1951. He noted that direct complications of true diverticula were remarkably few.<sup>4</sup>Although massive bleeding into the gastrointestinal tract has been reported,<sup>3</sup>it is an infrequent event, despite the fact that the mucosal lining of the diverticulum often shows considerable change due to trauma and inflammation. Brown et al<sup>4</sup>reported gastrointestinal bleeding in 2 of 30 cases. Recurrent bleeding into the intestinal tract has also been described.<sup>5</sup>Sutherland<sup>6</sup>reported a case of occult gastrointestinal bleeding due to hemorrhage from
Twelfth Annual Congress of the European Society for Medical Oncology
Journal: JNCI Journal of the National Cancer Institute (1986)

Twelfth Annual Congress of the European Society for Medical Oncology Get access JNCI: Journal of the National Cancer Institute, Volume 77, Issue 2, August 1986, Page 594, https://doi.org/10.1093/jnci/77.2.594-b Published: 01 August 1986
Journal Correction
Journal: Journal of Clinical Oncology (2011)

contained an error.In the Results section, under Safety, the last sentence of the second paragraph was given as:"Median time to improvement in grade 3 sensory neuropathy (to Յ grade 1) was 22, 22, and 19 days, respectively, for patients who received nab-paclitaxel 300 mg/m 2 q3w, 100 mg/m 2 weekly, and 150 mg/m 2 weekly compared with 37 days for patients who received docetaxel 100 mg/m 2 q3w."Whereas it should have been: "Median time to improvement in grade 3 sensory neuropathy (to Յ grade 2) was 22, 22, and 19 days, respectively, for patients who received nab-paclitaxel 300 mg/m 2 q3w, 100 mg/m 2 weekly, and 150 mg/m 2 weekly compared with 37 days for patients who received docetaxel 100 mg/m 2 q3w."The online version has been corrected in departure from the print.
Drinking Water Arsenic in Utah: A Cohort Mortality Study
Authors: Denise Riedel Lewis, J. Wanless Southwick, Rita Ouellet-Hellstrom, Jerry Rench, Rebecca L. Calderon
Journal: Environmental Health Perspectives (1999)

The association of drinking water arsenic and mortality outcome was investigated in a cohort of residents from Millard County, Utah. Median drinking water arsenic concentrations for selected study towns ranged from 14 to 166 ppb and were from public and private samples collected and analyzed under the auspices of the State of Utah Department of Environmental Quality, Division of Drinking Water. Cohort members were assembled using historical documents of the Church of Jesus Christ of Latter-day Saints. Standard mortality ratios (SMRs) were calculated. Using residence history and median drinking water arsenic concentration, a matrix for cumulative arsenic exposure was created. Without regard to specific exposure levels, statistically significant findings include increased mortality from hypertensive heart disease [SMR = 2.20; 95% confidence interval (CI), 1.36-3.36], nephritis and nephrosis (SMR = 1.72; CI, 1.13-2.50), and prostate cancer (SMR = 1.45; CI, 1.07-1. 91) among cohort males. Among cohort females, statistically significant increased mortality was found for hypertensive heart disease (SMR = 1.73; CI, 1.11-2.58) and for the category of all other heart disease, which includes pulmonary heart disease, pericarditis, and other diseases of the pericardium (SMR = 1.43; CI, 1.11-1.80). SMR analysis by low, medium, and high arsenic exposure groups hinted at a dose relationship for prostate cancer. Although the SMRs by exposure category were elevated for hypertensive heart disease for both males and females, the increases were not sequential from low to high groups. Because the relationship between health effects and exposure to drinking water arsenic is not well established in U.S. populations, further evaluation of effects in low-exposure populations is warranted.
Autologous blood donation for elective surgery. Effect on physician transfusion behavior
Authors: J. Wasman
Journal: JAMA (1987)

The hospital records of 69 autologous blood donors undergoing elective surgical procedures and those of matched controls were reviewed in an effort to assess whether autologous blood donation altered physician transfusion behavior. Physicians tolerated significantly lower admission (0.372 vs 0.437 [37.2% vs 43.7%]), nadir (0.304 vs 0.334 [30.4% vs 33.4%]), and discharge (0.326 vs 0.358 [32.6% vs 35.8%]) hematocrits in patients with autologous blood predeposits compared with matched controls. Additionally, 44 patients undergoing orthopedic procedures stored insufficient blood to prevent homologous blood exposure: ten of 17 patients could have avoided homologous blood if 4 U of autologous blood had been stored. Twenty-five patients undergoing nonorthopedic procedures stored an insufficient volume of blood to satisfy an unexpected transfusion need but were given transfusions of more than needed amounts of their own blood when transfusion was not clinically indicated. Future studies designed to maximize procurement of autologous blood are needed; a salutary effect on physician transfusion behavior would then be coupled with an autologous blood inventory that could eliminate homologous blood exposure in these patients. (<i>JAMA</i>1987;258:3135-3137)
Abstract 161: TRIM21 suppresses invasion of breast cancer cells
Authors: Xin Hu, Yue Jin, Yu Zhang, Boyuan Li, Youzhong Wan
Journal: Cancer Research (2019)

Abstract Trim21 is an E3 ligase that is involved in the regulation of metastasis. High-level expression of TRIM21 is associated with good prognosis of breast cancer. After transplantation in immunodeficient mice, TRIM21-depleted MCF7 cells form tumors that show evident local invasion, i.e., extensive infiltration of single tumor cells into nearby muscle fibers. Knockdown of TRIM21 increases the migration and invasion of MCF7 and T47D cells by altering the expression of genes that regulate epithelial to mesenchymal transition(EMT). TRIM21 interacts with Snail, a master regulator of EMT, and the B-Box domain of TRIM21 is essential for the interaction between TRIM21 and Snail. Overexpression of TRIM21 leads to increased ubiquitination and subsequent proteosomal degradation of Snail, while depletion of TRIM21 decreases the ubiquitination and degradation of Snail. Most Importantly, knockdown of Snail suppresses the increased migration and invasion of MCF7 and T47D cells caused by TRIM21 knockdown. Collectively, our study demonstrates that TRIM21 modulates EMT by mediating the stability of Snail in breast cancer cells. Citation Format: Xin Hu, Yue Jin, Yu Zhang, Boyuan Li, Youzhong Wan. TRIM21 suppresses invasion of breast cancer cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 161.
MANHOLES AS NUISANCES, THE CONTINUANCE OF WHICH MAY BE ENJOINED.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal