tbuckley/cabot-search huggingface dataset:
Diagnosis and Treatment of Diseases of the Liver and Billary Tract
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Erratum
Journal: Hepatology (1983)

In conclusion, any decision to replace old with new tests or to choose among available tests should be based on: (a) definition of the specific aim of the diagnostic investigation (screening or clinical gravity score or functional assessment); (b) well-defined methodology for statistical evaluation of diagnostic acccuracy to be applied to single tests and groups of tests (note that a highranking position for a test does not necessarily imply its choice: in fact, the test may also be redundant with respect to the preceding one), and (c) accurate analysis of feasibility and cost.In my opinion, any effort to perform well-designed studies to evaluate the diagnostic utility of laboratory tests should take into account all of these problems.No statistical method, however excellent, is good enough to avoid incorrect evaluations due to inappropriate pathophysiological and clinical concepts.
Obstetrics-Gynecology
Authors: Edward C. Hill
Journal: JAMA (1981)

In considering advances of the past year in obstetrics and gynecology, three areas of clinical significance have been selected. They are (1) the use of ritodrine hydrochloride in preterm labor, (2) the increasing recognition of<i>Chlamydia trachomatis</i>as a significant pathogen in the female reproductive organs, and (3) the use of fine-needle aspiration biopsy in lieu of the more traditional methods of tissue sampling. Of course, these events did not occur during just the past year, but they gained considerable attention during 1980. <h3>Ritodrine</h3> Prematurity is the leading cause of perinatal morbidity and mortality. It has been estimated that about 8% of liveborn infants in the United States weigh less than 2,500 g. Many cases are the result of "accidents" of pregnancy such as abruptio placentae, premature rupture of the membranes, and placenta previa. A large number, however, are caused by labor that begins prematurely without known cause. It is
PCDD/PCDF: human background data for Germany, a 10-year experience
Authors: O Päpke
Journal: Environmental Health Perspectives (1998)

This paper gives an overview of the development of the environmental or background exposure of humans to polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) in Germany.To determine the background exposure, adipose tissue, human milk, or blood can be used.The good comparability of the matrices analyzed is demonstrated.The daily consumption of low-level contaminated food, mainly of animal origin, leads to the accumulation of PCDDs/PCDFs in the human adipose reservoir.The influence of factors such as various eating habits, severe weight loss, age, and nursing (women only) on the human body burden is discussed.Because of decreasing emission of PCDDs/PCDFs into the environment, a decline of these components in humans could be observed over a time span of 10 years.
Ublituximab (TG-1101), a Novel Glycoengineered Anti-CD20 Monoclonal Antibody, in Combination with Ibrutinib Is Highly Active in Patients with Relapsed and/or Refractory Mantle Cell Lymphoma; Results of a Phase II Trial
Authors: Kathryn Kolibaba, John M. Burke, Heather D. Brooks, Daruka Mahadevan, Jason Melear, Charles M. Farber, Suzanne R. Fanning, Marshall T. Schreeder, Ralph V. Boccia, Peter Sportelli, Hari P. Miskin, Michael S. Weiss, Jeff P. Sharman
Journal: Blood (2015)
The impact of physical and psychological stress at work
Authors: Lars-Olof Persson
Journal: Annals of the Rheumatic Diseases (2002)

Background: It was hypothesised that negative RA related illness cognitions are strongly related to the neuroticism trait and act as a common factor behind other self reported subjective symptoms (pain and ADL status), mood, and positive RA related illness cognitions; but are unrelated to objective indices of impairment (disease duration, C reactive protein (CRP), and joint stiffness).Objective: To examine the relative influence of negative illness cognitions and neuroticism versus degree of impairment on subjective symptoms, positive illness cognitions, and mood in rheumatoid arthritis (RA).Methods: Structural equation modelling analyses (LISREL) were performed on two independent samples of patients with RA consisting of 212 outpatients and 105 inpatients, respectively.Results: The hypotheses were largely confirmed.Firstly, negative RA cognitions were found to be dependent on neuroticism.Secondly, negative RA cognitions had a strong and dominating influence on all other self reported data.Subjective symptoms were equally well explained by negative RA cognitions as by degree of impairment.No relations were found between negative RA cognitions (or neuroticism) and degree of impairment.Conclusions: The findings suggest that neuroticism, recognised as a relatively stable personality trait, strongly influences self rated symptoms and wellbeing in RA.This has important clinical implications concerning the use of standardised self rating questionnaires commonly used to assess illness status in RA and the long term effectiveness of psychological interventions and patient training courses in RA rehabilitation.. . . . . . . . . .
The Croonian Lectures ON TRYPANOSOMES CAUSING DISEASE IN MAN AND DOMESTIC ANIMALS IN CENTRAL AFRICA: Delivered before the Royal College of Physicians of London
Authors: D. Bruce
Journal: BMJ (1915)

I t expands aind contracts in an apparently normiial manner.'ltlie vesicular numrnur can be plainly heard in it, and per- Cllssion gives the same inote as obtained from fresh lungs.'lr'ie process w,Vil!be seen to be a modificationi of the old glycerine-carbolic imetlhodl, well known and often used to preserve anatomical specimens in ani elastic condition.The modifications are importaut, however; and the results fai' better than any obtained in tlie old way.Tbe idea of tl-e metlocis, first,to fix tlhe-tissues by the chromic and acetic acid solutioii, then to inltroduice the glycerine-carbolic solution, anid, finally, to get rid of tlhis, and practically to make an 'oil-tanned' lIng.7'The composition of the tlhree solutions, and the mode of using them are tlhen given.It does lnot appear tlhat, at tllat time, lhe lhad prepared aniy specimen of both ltungs, or that h-e sxubsequently exhibited, or published any descrip- tion of, any suchi.That which lie prepared (by his new metliod) to present to miie at New York in the spring of 1892 may perhaps have been-tlhe first.These lungs were sliglhtly patlhological.They did not remain in efficient working much miiore tlhani a year: partly, perhaps, owing to insufficient exercisinig.Meanwhile, in the early sumumer of 1892, I prepared, accordina to Ihis latest directions, a perfectly normal and complete specimeen of botlh lungs witlh traclhea.This was a complete suiecess.It was long used for demonstration at St. George's Hospital; and it still preserves its elasticity after tlhe lapse of nearly twenty-three years.IJnhappily, thlrough a preventable accident, it has quite recently developed a bad "puncture" which now disables it, tlhough it is still inflatable, for any cQmplete and lasting.inflation.!, That lougirecord, andVthe- fear lest, owing to his untimely death, the value of his latest method miglht otherwise be lost to science, make mue anxious to publish those simple directionis whicli enabled me to secure tlhat success, without the lhelp of any actual demonstration of his technique, or of auy know- ledge of the publisled details of hiis earlier method."Im'proved, Method for Prelaring Lungs it o0der toPreserzve their Elasticity and Gross A natomical A41pearancc.---Thelunas mlUst be removed intact, and the pulm-onary blood vessels cut as close to the hleart as possible.If it is intended to prepare both lungs the trachea should be cut as hiigh as possible.If only one is prepared, cut the bronchus at its juinction withi the tracllea.Insert and tie as large a cannula as possible in the bronchus or trachea, and in the pulmonary artery."
<i>Circulation</i> : Clinical Summaries
Journal: Circulation (2013)

Brugada Syndrome Behind Complete Right Bundle-Branch BlockBrugada syndrome (BS) and complete right bundle-branch block (CRBBB) can coexist.CRBBB can completely mask BS, but simultaneous diagnosis has never been attempted.This study represents the first series describing this phenomenon.In 11 patients who had BS and CRBBB, BS was diagnosed before the development of CRBBB, on the resolution of CRBBB, or from new characteristic ST-segment changes that could be attributable to BS.The QRS duration was more prolonged and the amplitude of R in V 1 was larger in the patients with BS and CRBBB compared with age-and sexmatched control subjects.In BS patients with CRBBB, relief of CRBBB, repeated ECG recordings, or pharmacological tests can be useful to demonstrate typical ST-segment elevation.The prevalence, mechanism, and clinical significance of the combination of CRBBB and BS need to be determined.See p 1048.
Comparisons of Estimated Human Body Burdens of Dioxinlike Chemicals and TCDD Body Burdens in Experimentally Exposed Animals
Authors: Michael J. DeVito, Linda S. Birnbaum, William H. Farland, Thomas A. Gasiewicz
Journal: Environmental Health Perspectives (1995)

Humans are exposed to mixtures of polyhalogenated aromatic hydrocarbons, and the potential health effects of these exposures are uncertain. A subset of this class of compounds produce similar spectra of toxicity in experimental animals as does 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), and these chemicals have been classified as "dioxins." In this study, we compared the body burdens of dioxins that produce effects in experimental animals to body burdens associated with these effects in humans. Human body burdens were estimated from lipid-adjusted serum concentrations of dioxins, assuming dioxins are equally distributed in body fat and an adult has 22% body fat. The toxic equivalency factor (TEF) method was used to calculate body burdens of dioxins in humans. These calculations included dibenzo-p-dioxins, dibenzofurans, and polychlorinated biphenyls. In the general population, average background concentrations were estimated at 58 ng TCDD equivalents (TEQ)/kg serum lipid, corresponding to a body burden of 13 ng TEQ/kg body weight. Populations with known exposure to dioxins have body burdens of 96-7,000 ng TEQ/kg body weight. For effects that have been clearly associated with dioxins, such as chloracne and induction of CYP1A1, humans and animals respond at similar body burdens. Induction of cancer in animals occurs at body burdens of 944-137,000 ng TCDD/kg body weight, while noncancer effects in animals occur at body burdens of 10-12,500 ng/kg. Available human data suggest that some individuals may respond to dioxin exposures with cancer and noncancer effects at body burdens within one to two orders of magnitude of those in the general population.
Leads from the MMWR
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dielectric Changes in Membrane Properties and Cell Interiors of Human Mesothelial Cells in Vitro after Crocidolite Asbestos Exposure
Authors: Elke Dopp, Ludwig Jonas, Barbara Nebe, Axel Budde, Eberhard Knippel
Journal: Environmental Health Perspectives (2000)

Asbestos induces cytogenetic and genotoxic effects in cultured cell lines in vitro. For further investigations of the fiber-induced cellular changes, electrorotation (ROT) measurements can be used to determine early changes of surface properties and dielectric cellular changes. In the present study, human mesothelial cells (HMC) were exposed to nontoxic concentrations of crocidolite asbestos (1 microg/cm(2)) for 12, 24, 30, 50, and 72 hr, and were investigated for changes in dielectric properties, morphologic and biochemical changes using ROT measurements, electron microscopy, and flow cytometry, respectively. The results of ROT measurements revealed slightly increased internal conductivity and decreased membrane conductance of HMC during the first 12 hr of exposure to crocidolite. This may be due to functional changes of ion channels of the cellular membrane. However, after exposures of >= 30 hr, reduced internal conductivity and increased membrane conductance of HMC occurred. These effects may be caused by permeabilization of the cell membrane and the leakage of ions into the surrounding medium. The membrane capacitance of HMC is always decreased during exposure of cells to crocidolite fibers. This decreased membrane capacitance may result from the observed reduction in the number of microvilli and from the shrinkage of cells as observed by electron microscopy and flow cytometry. Changes in composition of the plasma membrane were also observed after the labeling of phosphatidylserines (PS) on the cell surface. These observed changes can be related to apoptotic events. Whereas during the first 50 hr of exposure only a small number of HMC with increased exposure of PS on the cell surface was detected by flow cytometry, the dielectric properties of HMC showed marked changes during this time. Our results show that surface property changes of the cellular membrane of HMC as well as interior dielectric changes occur after the exposure of cells to crocidolite fibers. The observed changes are discussed in terms of complex combined cellular effects after amphibole asbestos exposure.
First Class
Authors: Francis D. Moore
Journal: New England Journal of Medicine (1980)

On Saturday, May 24, there will graduate a medical class that is unique among the 115 or so graduating this year: 29 physicians will receive M.D. degrees from our first federal medical school, the Uniformed Services University of the Health Sciences (USUHS) in Bethesda, Md.Established by an act of Congress in 1972, this medical school was founded to meet the needs of the uniformed services (Army, Navy, Air Force, and Public Health Service) by educating physicians committed to a career in the national service. In addition to the usual medical curriculum, students receive special education pertinent to the care . . .
Abstract P4-14-01: A time course study of genomic instability in breast cancer patients receiving neoadjuvant therapy with or without bevacizumab
Authors: EK Møller, HK Moen Vollan, S Nord, H von der Lippe Gythfeldt, H Edvardsen, L Silwal-Pandit, M Krohn, T Fleischer, E Schlitchting, E Borgen, Ø Garred, A Fangberget, MM Holmen, H Skjerven, S Lundgren, E Wist, B Naume, A-L Børresen-Dale, VN Kristensen, O Engebraaten
Journal: Cancer Research (2013)

Abstract Tumor heterogeneity is an area of intense research, revealing tumors with high complexity consisting of different subclones and infiltrating cells. Identification of subclones that are resistant to therapy may be critical to improve treatment outcome. The NeoAva study is a randomized phase II, clinical trial of Her2 negative breast cancer patients treated in a neoadjuvant setting with chemotherapy (FEC and taxane) +/- bevacizumab. Core needle biopsies were obtained at screening and after 12 weeks, and the tumor was surgically removed after 25 weeks. DNA copy number changes in the tumors were analyzed using Affymetrix SNP Array 6.0. Allele specific copy number changes were assessed using the Allele-Specific Copy number Analysis of Tumors (ASCAT) algorithm (Van Loo, Norgard et al., PNAS 2010) and allele-specific Piecewise Constant Fitting (asPCF) algorithms (Nilsen, Liestol et al., BMC Genomics 2012). Measures of genomic instability were obtained through the complex arm-wise aberration index (CAAI) that captures local rearrangements (‘firestorms’) (Russnes, Vollan et al., Sci Transl Med 2010). Changes in copy number aberrations between the three different time points were observed in almost all tumors. Some tumors showed a decrease in tumor percentage and aberrations after just 12 weeks of treatment, where others showed loss of aberrations only at the time of surgery (25 weeks). Most of the tumors that did retain aberrations at all time points during treatment, did not demonstrate any decrease in tumor size. Other profiles indicated subclonal reduction, where some aberrations are kept throughout treatment and others disappear. Many of the tumors shrinking in size showed fewer whole arm aberrations than before treatment, but retained their focal amplicons. Some of the tumor aberrations seem to disappear after 12 weeks, but to reappear after 25 weeks, but with the addition of novel aberration. Complex rearrangements were identified in 67% of tumors before treatment. The most frequent ‘firestorms’ were found on 20p, 11q and 8p. Some events were persistent through therapy, but the majority changed. An association between complex tumor genomes and patients having progressive disease/non-responders were observed. These results show the complex structure of a tumor and suggest that heterogeneity will influence the response to treatment. The subclonal patterns of tumors may be of great importance for clinical decision-making, as well as for monitoring treatment efficacy. Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr P4-14-01.
Spleen Puncture.
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Scientific Program
Journal: JAMA (1974)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medical News
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Acute Glomerulonephritis
Authors: Jerome P. Kassirer, William B. Schwartz
Journal: New England Journal of Medicine (1961)

Renal FunctionSome disturbance in renal function occurs in the majority of patients with acute glomerulonephritis. Many patients are found to have mild or moderate azotemia, and even when the blood urea nitrogen or serum creatinine concentration is not unequivocally elevated, more precise measurements by means of clearance technics often reveal some degree of impairment.96 A distinctive pattern of abnormalities has been demonstrated by many observers. In general, glomerular filtration rate, as measured by inulin, creatinine or urea clearance, is moderately or markedly depressed.92, 96 , 97 Reductions in renal blood flow and renal plasma flow are uncommon (except when severe renal failure . . .