tbuckley/cabot-search huggingface dataset:
Pre-exposure prophylaxis of rabies.
Journal: BMJ (1976)

Pre-exposure prophylaxis of rabiesThe risk of developing rabies after a bite by a rabid animal can be reduced to about a tenth by cleaning the wound vigor- ously and by active together with passive immunisation.1 2 The immunological mechanisms are poorly understood,3 but there are three major defects in this regimen.Firstly, the antibody response to conventional vaccines is unpredictable and is rarely evident unti.6-10 days after the first injection :4 by then
The emergency department surveillance of alcohol intoxication after motor vehicle accidents
Authors: G. Chang
Journal: JAMA (1988)

To assess the surveillance of alcohol intoxication by surgical house staff, we examined the charts of 346 motor vehicle accident patients who presented to the trauma center of an urban teaching hospital emergency department. Half of the charts were reviewed before and half were reviewed after June 1986, when Connecticut enacted PA86-345, a law changing court rules of evidence so that the analysis by a hospital of a patient's blood could be used to establish probable cause for driving while under the influence of an intoxicant. We predicted and found no change in house-staff practice after passage of the law, since information about intoxication was obtained for immediate treatment. The rate of testing remained constant at 25%, with the median alcohol concentration at 200 mg/dL. Not one patient was referred for alcohol abuse evaluation or treatment. We recommend more vigorous attempts to evaluate, diagnose, and refer patients who abuse alcohol since they threaten the public health. (<i>JAMA</i>1988;260:2533-2536)
Treatment of House Dust Allergy
Journal: BMJ (1968)

A controlled trial of the treatment of asthma by injections of a commercially produced extract of house dust is reported on 96 patients. The patients were allocated at random to two groups. One group received extract of house dust in a carbol saline solution, the other a carbol saline solution only. Some patients in both groups were advised on dust control in their houses. Results were available for comparison from 70 patients, 33 treated and 37 controls. Neither the treatment with house dust extract nor advice on dust control was found to give any advantage.
Stressed whites especially prone to 'trench mouth,' study finds
Authors: E. R. Gonzalez
Journal: JAMA (1983)

An attack of "trench mouth," or acute necrotizing ulcerative gingivitis (ANUG), has been associated with emotional disorders and high levels of psychosocial stress for some time. Now a new study not only pinpoints some of the resulting immunologic and endocrine dysfunctions but shows, rather surprisingly, that the condition affects many more whites than blacks. One hundred ANUG patients referred to the periodontal clinic were the volunteer subjects of a three-year study carried out by Ronald B. Cogen, DDS, PhD, associate professor of dentistry, University of Alabama School of Dentistry, Birmingham, and coinvestigators Alvin W. Stevens, Jr, DMD, associate professor of dentistry, and Steven A. Cohen-Cole, MD, associate professor of psychiatry at the university's medical school. Like ANUG patients in general, these patients were relatively young, ranging in age from 14 to 35 years with a mean of 23.9 years. Males constituted 40% of the group. In contrast to the general
Cosmetic facial surgery
Authors: R. Kotler
Journal: JAMA (1983)

COSMETIC surgery of the face has been performed in this country since the turn of the century, but until recently, most of it had been done surreptitiously and had frequently been considered an indulgence of only the wealthy or the vain. Cosmetic facial surgery has burgeoned in the past decade. The reasons are many, including our continuing affluence, job competition, the fitness boom, and, of course, the publicity given public figures who have openly discussed their cosmetic facial surgery. Some of the types of cosmetic facial surgery generally available are discussed in the following sections. <h3>Cosmetic Nasal Surgery</h3> Rhinoplasty continues to be the most frequently performed cosmetic facial surgical procedure. Today's operation is a perfection of the technique originally developed in the 1920s by Jacques Joseph, a Berlin orthopedic surgeon. Rhinoplasty surgery, now performed entirely through incisions within the nose, has undergone the maturation and sophistication capable of yielding results
Combination of NA, PEG-IFN alpha-2b and GM-CSF enhanced hbsab production in NA experienced CHB patients (the anchor a study): an interim analysis
Authors: Di Wu, Weiming Yan, Deming Tan Tan, Shifang Peng, Yongping Chen, Jiaji Jiang, Xin-Yue Chen, Xiaoguang Dou, Ke Ma, Peng Wang, Ping Yin, Li Sun, Meifang Han, Qin Ning
Journal: Journal of Hepatology (2020)
Flower Power
Authors: Jorge Roman
Journal: JAMA Dermatology (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
The Code
Authors: Katharine Treadway
Journal: New England Journal of Medicine (2007)

"Code Call Baker 632," announced an urgent voice over the hospital intercom. Simultaneously, the code beeper worn by our team's resident went off. We sprinted to the 6th floor of the Baker building. As we rounded the corner, we saw the crash cart in the hall, which directed us to the right room. Several residents were already there when we arrived. The chaos of the residents rapidly sorted itself out under the calm guidance of the senior resident, who directed the chest compressions and the Ambu bagging until the resident who would intubate the patient was ready. Someone else slipped . . .
Computed tomography in the diagnosis of abdominal hemorrhage
Authors: E. S. Alexander
Journal: JAMA (1982)

IN A patient with a history of trauma, sudden abdominal pain, falling hematocrit reading, and an abdominal mass, the diagnosis of retroperitoneal hemorrhage is secure. In many cases, however, the clinical presentation is not classic, and the diagnosis is difficult. The patient may have only vague abdominal pain and no other clinical findings. No documented decrease in hematocrit reading may exist, even though the hematocrit reading may be low and no palpable abdominal mass or history of trauma may be present. Although hemorrhage may be suspected, confirmation is difficult.<sup>1</sup>Conventional radiological findings are often subtle. Computed tomography (CT) offers a simple means of confirming suspected hemorrhage. With CT, peritoneal or retroperitoneal hemorrhage and its extent generally can be detected. On occasion, the reason for the hemorrhage can also be determined. This is important in determining appropriate treatment. <h3>General Considerations</h3> Hemorrhage into the peritoneal cavity appears on CT scan as
Prepaid health.
Authors: G Dunea
Journal: BMJ (1980)

DUNEAThe unattractive term "health care delivery," now firmly established in the American language, implies that health care, like salami, can be delivered in a grocery van-and conjures up the figure of a man in a white coat bringing cartons of soft drinks and potato chips, a cabbage, a new invigorating facial tonic, and a giant-size package of disposable health care.A bill, scribbled on yellow paper and left pinned to the merchandise, symbolises the rapaciousness of capitalist degeneracy.More equitable then would be to pay a monthly predetermined premium and receive in return all the groceries you need, or at least all the groceries your grocer thinks you need.In medicine, such prepayment plans date back to the ancient Chinese, who paid their doctor when they were well but not when they were sick.They are now being tried in America to solve the problem of rising costs; and, being based on the principle that health can be maintained as well as delivered, are appropriately termed health maintenance organisations (HMOs). Growth of the HMOsPrepaid medical plans, though sometimes advertised as the greatest medical advance of the century, date back at least to
Rare Diagnosis: Sarcoid Arthritis In Four Children
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Error in Course Title
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE LOST ARTS
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fatal fat embolism after spinal fusion for scoliosis
Authors: J. E. Gittman
Journal: JAMA (1983)

An adolescent girl who underwent Harrington instrumentation and spinal fusion for idiopathic scoliosis had the adult respiratory distress syndrome develop in the immediate postoperative period. Massive fat embolization to the lungs was present at postmortem examination, an apparently rare complication of this surgical procedure. This case emphasizes the necessity of maintaining a high index of suspicion in any clinical setting that would place a patient at risk for fat emboli and illustrates the unreliability of many of the clinical and laboratory features frequently described as useful for establishing the diagnosis. (<i>JAMA</i>1983;249:779-781)
Phase II Trial of Biweekly Administration of Vinorelbine and Gemcitabine in Pretreated Advanced Breast Cancer
Authors: George P. Stathopoulos, Sotiris K. Rigatos, Nikos Pergantas, Dimitris Tsavdarides, Ilias Athanasiadis, Nikos A. Malamos, John G. Stathopoulos
Journal: Journal of Clinical Oncology (2002)

PURPOSE: To determine the efficacy of gemcitabine (GEM) plus vinorelbine (VRL) administered biweekly in pretreated patients with advanced breast cancer. PATIENTS AND METHODS: Advanced breast cancer patients without response, with stable disease, or with recurrence within 6 months of prior treatment were given GEM 1,000 mg/m 2 and VRL 25 mg/m 2 , once every 2 weeks for at least six cycles. RESULTS: Of the 51 patients enrolled, 50 (median, age 58 years; range, 34 to 76 years) were assessable. All patients had prior chemotherapy with an anthracycline-related regimen that included taxanes in 50% of the cases. Four patients (8%) had a complete response (CR) and 23 (46%) had a partial response (PR), for an overall response rate of 54%; 16 (32%) had stable disease and 7 (14%) experienced disease progression. Response occurred mainly in patients with soft tissue (83.3%) and lung metastasis (66.7%). Response duration was 4 to 8+, 4 to 9+, and 4 to 9 months for those with CR, PR, and stable disease, respectively. The regimen was well tolerated, with grade 1 to 2 myelotoxicity and asthenia reported. No patient required a dose reduction. Gastrointestinal side effects were negligible. Patients received 99.7% (range, 93.0% to 100.0%) of the planned dose-intensity of each drug. CONCLUSION: GEM in combination with VRL is an active regimen for advanced breast cancer patients, and biweekly administration significantly reduces myelotoxicity.
Abstract 172: BCL11A regulation of extracellular matrix genes may be necessary for invasion of triple-negative breast cancer
Authors: Natasha N. Ingles, Darcie Seachrist, Ruth Keri
Journal: Cancer Research (2019)

Abstract Triple-negative breast cancer (TNBC) represents 15% of all breast cancers, yet conveys the poorest patient prognoses due to the lack of targeted therapies and the high incidence of metastatic recurrence. This prompt recurrence is thought to be due, in part, to the high proportion of cancer stem cells (CSC) within TNBC tumors. Therefore, understanding what regulates CSCs and metastasis will allow us to significantly reduce cancer-related deaths. One of the transcription factors that is upregulated in TNBC is BCL11A, which is critical for CSC biology. We have found that BCL11A is necessary for TNBC invasion and metastasis. However, the genes that BCL11A targets to control invasion and metastasis are unknown. To identify the BCL11A-regulated transcriptome, we performed RNA-seq analysis of MDA-MD-231 TNBC cells transiently transfected with BCL11A-targeted siRNA or a non-silencing control. Gene set enrichment analysis of the differentially expressed genes revealed enrichment of genes involved in extracellular matrix and matrisome genes. Notably, BCL11A silencing reduced expression of several matrix-metalloproteases, with MMP1 being the most significantly differentially expressed gene. Thus, we hypothesize that BCL11A promotes TNBC invasiveness and metastasis through regulation of MMP expression. We confirmed downregulation of MMP1 and MMP9 mRNA and protein in response to BCL11A silencing by both qRT-PCR and western blot in independent MDA-MB-231 cells, as well as in the HCC1143 TNBC cell line. MMP activity was also reduced when assessed by fluorokine assay and gelatin zymography, for MMP1 and MMP9, respectively. Furthermore, both BCL11A and MMP expression is increased in brain-seeking clones of MDA-MB-231 cells and MMP1 and 9 expression is also reduced with BCL11A silencing. Together, these data suggest that BCL11A regulates TNBC invasion by reducing the expression of MMP1 and MMP9. Current studies are directly assessing the functional impact of MMP regulation by BCL11A on invasion and metastatic progression of TNBC. Citation Format: Natasha N. Ingles, Darcie Seachrist, Ruth Keri. BCL11A regulation of extracellular matrix genes may be necessary for invasion of triple-negative breast cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 172.
Pharmacologic Aspects of Adrenocortical Steroids and ACTH in Man
Authors: George W. Thorn, Dalton Jenkins, John C. Laidlaw, Frederick C. Goetz, Joseph F. Dingman, Walter L. Arons, David H. P. Strebten, Brian H. McCracken
Journal: New England Journal of Medicine (1953)

Effect of cortisone on growth: An impressive array of evidence demonstrates that under certain conditions body growth is suppressed by oxygenated corticosteroids145 or by intensive adrenocortical stimulation with ACTH.323 Cortisone fails to sustain a normal growth rate in young, immature, adrenalectomized rats324 and, in large doses, frankly inhibits growth in mature adrenalectomized325 and normal209 rats. Furthermore, inhibition may be extreme, despite a greatly increased food intake during cortisone administration. Since high-level cortisone treatment may interfere with growth of epiphyseal cartilage in immature animals, and suppress chondrogenesis and osteogenesis in mature rats,227 it is not surprising that elevated levels of corticosteroids . . .
Angular cheilosis
Authors: P. B. Mumford
Journal: British Journal of Dermatology (1967)

Journal Article Angular cheilosis Get access P. B. Mumford P. B. Mumford Manchester Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 79, Issue 8-9, 1 August 1967, Page 503, https://doi.org/10.1111/j.1365-2133.1967.tb11542.x Published: 01 August 1967
Analysis of Control Methods: Mercury and Cadmium Pollution
Authors: Alan MacGregor
Journal: Environmental Health Perspectives (1975)

Physical system conceptual models are developed to illustrate the various interconnecting pathways of metal flow. Economic use of mercury and cadmium, as representative toxic heavy metals, is inventoried, and the losses of each from the pathways of economic use are compared. Distinctions are made between high volume consumers and industries that are responsible for a large percent of total emissions or effluent loads. The pathways of the metals in the environment are traced via the conceptual models. A global mass balance is presented for mercury. The problem of high local concentrations vs. global metal flow is reviewed. Impacts of the metals on human health are categorized by type of effect. Available control strategies and abatement measures are evaluated with respect to the effectiveness of each on the problems of metal pollution, as illustrated by the physical models.
Homicide Followed by Suicide—Kentucky, 1985-90
Journal: JAMA (1991)

During March-May 1990, three widely publicized homicides followed by suicides occurred in Kentucky. Because the three incidents shared many features, the Division of Epidemiology, Department for Health Services, Kentucky Cabinet for Human Resources, conducted a study to determine the extent of the problem and the characteristics of perpetrators and homicide victims. This report presents the findings of this study.
CLINICAL ILLUSTRATIONS OF SOME DISEASES OF THE OESOPHAGUS
Authors: C. E. Reeves
Journal: BMJ (1853)

7M1, dieie or any surgical operation; but when the loss is a daily occurece with every motion, and so profuse a to produce all the distressing symptoms of anemia, extreme pillor, shortness of breathing upon the slightest exertion, palpitation, beating of the temporal arteries, indicating great debility, it becomes absolutel necessary to stop the bleeding, lest the constitution should sink from sheer ex- haustion; for we must remember that this is not a mere case of occasional piles from local causes, such as a costive habit of body, the gravid uterus, etc., where there is no hepatic obstruction, but a bleeding from an extensive sys- tem of obstructed veins without valves, and therefore more apt to bleed profusely.The remedy which will be found most efficacious in re- straining such hmmorrhage, is the purified oil of turpentine, with the tincture of kino, as prescribed in the following formula: & Olei terebinthinte pur. 3 ss.
Wolfenden Report
Authors: H. Walker
Journal: BMJ (1959)

<h3>Abstract</h3> Peptide agonists of the glucagon-like peptide-1 receptor (GLP-1R) have revolutionized diabetes therapy, but their use has been limited by the requirement for injection. Here we describe the first effective, orally bioavailable small molecule GLP-1R agonists. A sensitized high-throughput screen identified a series of small molecule GLP-1R agonists that were optimized to promote endogenous GLP-1R signaling with nM potency. These small molecule agonists increased insulin levels in primates but not rodents, which is explained by a cryo-EM structure that revealed a binding pocket requiring primate-specific tryptophan 33. Importantly, oral administration of agonist PF-06882961 to healthy humans produced dose-dependent declines in serum glucose (NCT03309241). This opens the door to a new era of oral small molecule therapies that target the well-validated GLP-1R pathway for metabolic health. <h3>One Sentence Summary</h3> PF-06882961 is an orally administered small molecule that activates the GLP-1 receptor to lower blood glucose in humans.