tbuckley/cabot-search huggingface dataset:
Proposed Animal Care Bills 'Restrictive, Punitive'
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
New approaches to prolonging survival of transplanted organs
Journal: JAMA (1979)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mesenchymal Tumors of the Mediastinum: II. Tumors of Blood Vascular Origin
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Revised guidelines for managing acute MI
Authors: M. F. Goldsmith
Journal: JAMA (1997)

THE RECENTLY issued<i>Guidelines for the Management of Patients With Acute Myocardial Infarction</i>(MI) "contain much that is new in terms of the rubric doctors follow," according to Thomas J. Ryan, MD, first author of the new edition. Since the original guidelines were published by the American College of Cardiology (ACC) and American Heart Association (AHA) in 1990, he said at the AHA's annual scientific sessions in New Orleans, La, advances in diagnosis and treatment that have come into practice through an "evidencebased medicine" approach dictated the current revision (published in<i>J Am Coll Cardiol</i>. 1996;94:2341-2350). After reviewing some 5000 US and European publications, many of which included data from controlled clinical trials, members of the guideline committee created the new document, which is written for a multidisciplinary audience. It has been endorsed by the American Association of Critical Care Nurses, American College of Emergency Physicians, and American Society of
Congenital Variety of the "Subclavian Steal" Syndrome
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tinnitus Aurium and Vitamin A: A Double-Blind Study
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Microcystic Cyanobacteria Extract Induces Cytoskeletal Disruption and Intracellular Glutathione Alteration in Hepatocytes
Authors: Wen-Xing Ding, Han-Ming Shen, Choon-Nam Ong
Journal: Environmental Health Perspectives (2000)

Microcystins are a group of highly liver-specific toxins, although their exact mechanisms of action remain unclear. We examined the effects of microcystic cyanobacteria extract (MCE) collected from a contaminated water source on the organization of cellular microtubules (MTs) and microfilaments (MFs) in hepatocytes. We also investigated the effects on lactate dehydrogenase (LDH) leakage and intracellular glutathione (GSH). Primary cultured rat hepatocytes exposed to MCE (equivalent to 125 microg/mL lyophilized algae cells) showed a characteristic disruption of MTs and MFs in a time-dependent manner. Under these conditions, MCE caused aggregation of MTs and MFs and a severe loss of MTs in some cells. Moreover, MCE-induced cytoskeletal alterations preceded the LDH leakage. On the other hand, the treatment of cells with MCE led to a dose-dependent increase of intracellular GSH. However, time-course study showed a biphasic change of intracellular GSH levels with a significant increase in the initial stage followed by a decrease after prolonged treatment. Furthermore, pretreatment with N-acetylcystein (NAC), a GSH precursor, significantly enhanced the intracellular GSH level and decreased the MCE-induced cytotoxicity as well as cytoskeleton changes. In contrast, buthionine-(S, R)-sulfoximine, a specific GSH synthesis inhibitor, increased the cell susceptibility to MCE-induced cytotoxicity by depleting the intracellular GSH level. These findings suggest that intracellular GSH plays an important role in MCE-induced cytotoxicity and cytoskeleton changes in primary cultured rat hepatocytes. Increasing intracellular GSH levels protect cells from MCE-induced cytotoxicity and cytoskeleton changes.
Leads from the MMWR
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Endocardiac pacemaker-induced diaphragmatic contractions
Authors: T. E. Palmer
Journal: JAMA (1967)

PERMANENT implantable endocardiac pacemaker systems have greatly extended the surgical treatment of heart-block. Patients judged to be unfit for thoracotomy may now be offered substantial symptomatic relief with a relatively lowrisk operation employing local anesthesia. Early in the clinical experience of permanent endocardiac pacing, one expected electrode dislodgement, intermittent contact of the electrode due to myocardial contraction, rising myocardial impedance to electrode stimulation, predisposition to thrombosis by the large intravascular foreign body electrode, and possibly tricuspid insufficiency. Prior to treating the two patients described in this report, we had encountered only dislodgement and intermittent contact of the bipolar electrode. These complications have been uncommon and have been noted early in the postoperative period. They have been easily remedied by further manipulation through the same incisions, with the patient under local anesthesia. Recently, we have seen two patients who presented with vigorous diaphragmatic contractions noted approximately six weeks and four months
Medical Greats
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cell may lose 'killer instinct'
Authors: P. Gunby
Journal: JAMA (1983)

Since discovery of the leukocyte subpopulation called "natural killer (NK) cells," researchers have been studying what these "lymphocytes that act like phagocytes" do. Now, Salt Lake City investigators have clues as to what may happen in the<i>absence</i>of NK cells. The team, from the University of Utah College of Medicine and Latter-Day Saints Hospital, assayed for NK cell activity in 16 patients with idiopathic, dilated (congestive) cardiomyopathy. This disorder, while not well understood, is believed to involve immunologic and viral factors. The activity of the patients' mononuclear lymphocytes was assayed with a cell line commonly used as a "target" for NK cells. Results showed that NK cell activity was virtually absent in eight of the 16 patients. When those eight patients were retested six months later, NK cell activity had returned to normal in one—the only one among the eight who had quickly recovered from the cardiomyopathy. This could
Pill camera
Authors: S. von Delius, R. Schmid, A. Meining
Journal: Endoscopy (2010)

A 67-year-old man with a history of renal insufficiency due to membranous glomerulonephritis was referred to our endoscopy suite for capsule endoscopy for further evaluation of anemia and recurring positive guaiac fecal occult blood testing. Colonoscopy 8 months earlier and a recent upper gastrointestinal endoscopy had shown no abnormalities. After obtaining informed consent and bowel preparation, wireless capsule endoscopy was done for obscure gastrointestinal bleeding using the PillCam SB video capsule (Given Imaging, Yoqneam, Israel). The capsule study showed rapid small-bowel transit (24 minutes) and angiodysplasias in the right hemicolon. In addition, to our surprise and in contrast to the previously negative colonoscopy, we also found a polypoid lesion in the right hemicolon measuring about 1 cm in diameter ([Fig. 1]). The patient was scheduled for complete colonoscopy with argon plasma coagulation and polypectomy the following day. Argon plasma coagulation of the angiodysplasias in the cecum and sigmoid colon was carried out successfully. In the ascending colon we found a flesh-colored pill, which had been mistaken for an adenomatous polyp at capsule endoscopy ([Fig. 2]). The mucus surrounding the tablet was easily washed off through the colonoscope. [Fig. 3] shows a multivitamin tablet with a similar appearance.
Miscellany
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE INDISCRIMINATE USE OF ALCOHOL.TEMPERANCE IN FRANCE.
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Immunologic reaction to duck embryo rabies vaccine
Authors: P. L. Perine
Journal: JAMA (1968)

Local cutaneous reactions and diffuse neurological dysfunction occurred in a patient during immunization with duck embryo rabies vaccine. Attempts to isolate an infectious agent were not successful, and it was concluded that the illness was the result of an immunologic reaction to the vaccine. The patient recovered without specific therapy. The patient's serum contained precipitating antibodies against the vaccine, and intradermal testing with the vaccine induced induration at 24 hours. These findings were interpreted to indicate that both Arthus-like reactions and delayed hypersensitivity may have to be operative in the clinical disorder.
Chronic pyelonephritis as a cause of renal failure in dialysis candidates. Analysis of 173 patients
Authors: H. Schechter
Journal: JAMA (1971)

Chronic pyelonephritis was found to be the primary cause of end-stage renal failure in 22 (13%) of 173 dialysis candidates and was almost always associated with an underlying structural defect. Unequivocal nonobstructive chronic pyelonephritis was not found. Documented infection of the urinary tract was infrequent among 49 (28%) patients in whom a definite diagnosis could not be established. Chronic glomerulonephritis was the most frequent cause of end-stage renal failure in the series. This study has implications in regard to bacteriological screening programs.
CAMP-FOLLOWERS OF SCIENCE.
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Toxic effects of lithium carbonate in a mother and newborn infant
Authors: G. D. Wilbanks
Journal: JAMA (1970)

A patient receiving carefully monitored lithium carbonate therapy in late pregnancy developed a toxic condition during the delivery process, apparently due to hemodynamic or metabolic alterations or both, as no additional lithium carbonate was given. Massive diuresis was effective treatment. The infant also had elevated serum lithium ion levels with the clinical signs of cyanosis and flaccid muscle tone. Both mother and infant have recovered without obvious permanent damage. Extreme caution should be used with lithium carbonate therapy in late pregnancy until further data can be obtained on the maternal-fetal relationship. The promise of effective therapy must be weighed with therapeutic benefit.
Dickens and medicosocial reform
Authors: E. Gaskell
Journal: JAMA (1971)

Few writers have reflected their times and environment to better advantage than Dickens. His rich gallery of characters represents an essential part of England as it was in the mid-19th century. Real as they are, these characters move in situations often no more invented than they themselves were; but always fact is accompanied by invention and reality dissolves into art. Dickens possessed the eye and memory of a trained reporter, allied with the originality of a born story-teller. Some would say that his imagination tended to run riot and produced as many caricatures as genuine pictures. But the art of caricature enjoyed immense popularity amongst the Victorians. There is no single approach to Dickens—no more than to any great socially involved novelist—and the subject of medicine offers just one of several roads into his fictional world. At the same time it must be admitted that his doctors rarely seem to