tbuckley/cabot-search huggingface dataset:
Blueberry Muffins and Mystery Novels
Authors: Mark Linzer
Journal: Annals of Internal Medicine (1994)

Letters15 December 1994Blueberry Muffins and Mystery NovelsMark Linzer, MDMark Linzer, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-121-12-199412150-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:If only we all had the opportunity to establish long-lasting and meaningful relationships with patients on a daily basis! Certainly, few patients today would say that their physicians connect with them, explain things clearly, and take the time to get to know them. As Co-Chair of the Society of General Internal Medicine's Task Force on Career Choice, I have spent years asking medical students why they are no longer interested in careers in internal medicine [1, 2]. The reason given most often is an inability to establish meaningful relationships with patients during medical training. The students ask us ...References1. Schwartz MD, Linzer M, Babbott D, Divine GW, Broadhead E, and the Society of General Internal Medicine (SGIM) Interest Group on Career Choice in Internal Medicine. Medical student interest in internal medicine. Ann Intern Med. 1991; 114:6-15. Google Scholar2. McMurray JE, Schwartz MD, Genero NP, Linzer M, for the Society of General Internal Medicine Task Force on Career Choice in Internal Medicine. The attractiveness of internal medicine: a qualitative analysis of the experiences of female and male medical students. Ann Intern Med. 1993; 119:812-8. Google Scholar3. Matthews DA, Suchman AL, Branch WT Jr. Making “connexions”: enhancing the therapeutic potential of patient-clinician relationships. Ann Intern Med. 1993; 118:973-7. Google Scholar4. Lewis CE, Prout DM, Chalmers EP, Leake B. How satisfying is the practice of internal medicine? Ann Intern Med. 1994; 114:1-5. Google Scholar5. Quindlen A. The human touch. New York Times. 14 May 1994. Google Scholar Author, Article, and Disclosure InformationAuthors: Mark Linzer, MDAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 December 1994Volume 121, Issue 12Page: 986-987KeywordsBurnsFearLength of stayOutpatientsPerception ePublished: 15 August 2000 Issue Published: 15 December 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
ITALY
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Infant-Feeding.
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Quantitative magnetic resonance imaging predicts individual future liver performance after liver reception for cancer
Authors: Damian Mole, Jonathan Fallowfield, Fenella Welsh, Ahmed Sherif, Tim Kendall, Scott Semple, Matt Kelly, Ged Ridgway, John Connell, Henry Wilman, John McGonigle, Velicia Bachtiar, Rajarshi Banerjee, Sir Michael Brady, Dr Xiaozhong Zheng, Lucile Neyton, Anya Adair, Prof Ewen Harrison, Andrew Healey, Rowan W. Parks, Ravi Ravindran, Sarah Thomasset, Prof Stephen Wigmore, Prof O James Garden, Dr Michael Hughes, Joanna McClintock, Garry Tucker, Hilary Nailon, Dr Dilip Patel, Jim Gordon-Smith, Hamish Ireland, Neil Masson, Anthony Wackett, Michelle Steven, Angela Watson, Dr Delia Peppercorn, Dr Karen Scott, Dr Andrew Thrower, Myrddin Rees
Journal: Journal of Hepatology (2020)
Human growth hormone levels in normal subjects receiving an oral contraceptive
Authors: W. N. Spellacy
Journal: JAMA (1967)

Human growth hormone (HGH) levels were measured by a double antibody radioimmunoassay of plasma from women in both the fasting state, and after insulin-induced hypoglycemia. The tests were performed on 26 normal, ambulatory females'at rest, as a control, and also during the third treatment cycle with a combination-type oral contraceptive. It was found that the oral contraceptive elev[ill] the HGH levels. This would appear to be the mec[ill]m by which oral contraceptives alter carbohydrate metabolism.
Thyroid Carcinoma
Authors: Steven I Sherman, Peter Angelos, Douglas W Ball, David Byrd, Orlo H Clark, Gilbert H Daniels, Raza A Dilawari, Hormoz Ehya, William B Farrar, Robert F Gagel, Fouad Kandeel, Richard T Kloos, Peter Kopp, Dominick M Lamonica, Thom R Loree, William M Lydiatt, Judith McCaffrey, John A Olson, John A Ridge, Jatin P Shah, James C Sisson, R Michael Tuttle, Marshall M Urist
Journal: Journal of the National Comprehensive Cancer Network (2007)

Although thyroid carcinoma is relatively uncommon, approximately 33,550 new cases will be diagnosed in the United States in 2007. It occurs 2 to 3 times more often in women than in men, and with the incidence increasing by 4% per year, it is currently the eighth most common malignancy diagnosed in women. Although it occurs more often in women, mortality rates are higher for men, probably because they are usually older at the time of diagnosis (65–69 years vs. 50–54 years in women). Interestingly, the incidence of thyroid carcinoma increased almost 240% between 1950 and 2000, but mortality rates decreased more than 44%. Important updates to the 2007 guidelines include revised criteria for categorizing disease, revised recommendation for thyroid-stimulating hormone–stimulated thyroglobulin in some cases, and expanded CT recommendations for anaplastic carcinoma. For the most recent version of the guidelines, please visit NCCN.org
Aortocoronary bypass operations
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medical News
Journal: JAMA (1981)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BOOK REVIEW
Authors: C. S. YANG
Journal: JNCI Journal of the National Cancer Institute (1994)

BOOK REVIEW Get access Carcinogenesis Michael P. Waalkes , Jerrold M. Ward , eds. New York : Raven Press , 1994 , 478 pp., illus. $100. ISBN 0-7817-0124-4 CHUNG S. YANG, PH.D. CHUNG S. YANG, PH.D. Laboratory for Cancer Research College of Pharmacy Rutgers University PiscatawayNJ 08854 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 86, Issue 22, 16 November 1994, Page 1720, https://doi.org/10.1093/jnci/86.22.1720 Published: 16 November 1994
THU0032 Predicting the Evolution of Inflammatory Arthritis in ACPA-Positive Individuals: can T-Cell Subset Help?
Authors: L. Hunt, J. L. Nam, C. Rakieh, P. Emery, F. Ponchel
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> ACPA+ individuals with non specific musculoskeletal symptoms are at high risk of developing rheumatoid arthritis (RA). We previously demonstrated dys-regulation of T-cell subsets with loss of naïve and regulatory T-cell (Treg) in early disease. <h3>Objectives</h3> The aim of the current study is to demonstrate the biomarker value of T-cell subset analysis for the prediction of symptom onset in ACPA+ individuals. This preliminary data aims to highlight the clinical application of T-cell subset analysis within a predictive model for rheumatoid arthritis. <h3>Methods</h3> 64 ACPA+ individuals without clinical synovitis at recruitment were followed in the rheumatology clinic for up to 52 months. At baseline T-cell subset analysis was performed using 6 colour flowcytometry for naïve T-cell (CD4+CD45RB+CD45RA+CD62L+), Treg (CD4+CD25<sup>high</sup>Foxp3+CD127<sup>low</sup>) and inflammation related cells (IRC: CD4+CD45RB+CD45RA+CD62L-). Analysis of 75 healthy controls (HC) enabled a reference group. <h3>Results</h3> 33/64 (51.5%) patients developed clinical synovitis within a median follow-up of 6.1 months (range 1 week to 49 months). Of these 5 were diagnosed as undifferentiated arthritis (UA) and 28 meet the ACR/EULAR 2010 criteria for RA. Within those patients who progressed to synovitis T-cell subset analysis revealed disturbance from health in all 3 subsets. Both naïve T-cell frequency (p=0.003) and regulatory T-cell (p&lt;0.0001) were reduced, while inflammation related cells (IRC, p=0.017) frequencies were increased. Groups however were not aged matched. Progression towards synovitis was associated with lower naïve (p=0.005) and Treg (p=0.004) frequency but increased IRC (p&lt;0.0001). To develop a predictive model, naïve cells were coded (normal or reduced) according to the age-adjusted 95% CI of data obtained from the 75 HCs, and Treg / IRC using the 95%CI of the HC distribution as not related to age. Progression was associated with reduced naïve T-cells (p=0.009), reduced Treg (p=0.022) and increased IRC (p=0.001). Regression using these 3 parameters confirmed IRC (p=0.001) and naïve cells (p=0.011) as independent predictors of progression but Treg were less predictive as most patients showed clear reduction compared to HC95%CI (p=0.097). <h3>Conclusions</h3> T-cell dys-regulation in ACPA+ individuals with non-specific musculoskeletal pain may be useful in predicting progression to inflammatory arthritis. <h3>Disclosure of Interest</h3> L. Hunt: None Declared, J. Nam: None Declared, C. Rakieh: None Declared, P. Emery Consultant for: Abbott, BMS, Chugai, MSD, Pfizer, Roche, UCB., F. Ponchel: None Declared
State- and Sex-Specific Premature Mortality Due to Ischemic Heart Disease—1985
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Army emphasizes burn research, treatment; Air Force provides rapid transportation
Authors: C. Marwick
Journal: JAMA (1989)

FOR 40 YEARS, the US Army's Institute of Surgical Research, Fort Sam Houston, San Antonio, Tex, has played a central role in the development and improvement of therapy for the patient with burns. The institute's director, COL Basil A. Pruitt, MC, USA, says that when the staff encounters a significant problem, it can be brought from the clinic to the laboratory, where possible solutions can be explored. "This relationship has been responsible for some of the significant improvements in burn care over the years," he says. "In turn, this has been reflected in improved survival." Pruitt cites development of topical chemotherapy: "Investigation of this has made possible the excision procedures that are now widely employed in burn patients, allowing earlier wound closure. This reduces the duration and magnitude of physiologic stress, reduces the period during which the patient is at risk of infection, and gives improved functional and cosmetic results."
Infantile Cortical Hyperostosis (Caffey's Disease)
Authors: Lynn T. Staheli
Journal: JAMA (1968)

Sixteen cases of infantile cortical hyperostosis were reviewed with a late follow-up evaluation of eight. An onset in early infancy, irritability, soft-tissue swelling, and cortical hyperostosis were the characteristic features of the disease. Undoubtedly, many cases go unrecognized, since two of the 16 cases were found incidentally when roentgenograms were made to evaluate the respiratory tract for unrelated problems. Seven infants had mandibular involvement alone, and in one other the scapula was the only bone affected. At late follow-up, all eight patients were asymptomatic. Two had mandibular asymmetry and one had synostoses between two ribs and between a tibia and fibula. The clustering of cases during the first years of the study suggests that the disease is due to an exogenous agent.
Substitution of Drugs
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Miscellany
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Eagleton's Index and Abstracts of Literature on Progress in Intracranial Lesions Related to Aural and Nasal Conditions
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Constant Gardener
Authors: Jeanner Lenzer
Journal: BMJ (2005)

Directed by Fernando Meirelles US release date: 26 August UK release date: 7 October http://www.theconstantgardener.com/ Rating: ![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img>![Graphic][4]</img> A Harris Poll last year that found only 13% of the US public believes that pharmaceutical firms are “generally honest and trustworthy.” That low regard puts drug companies on a par with tobacco and oil companies. However, drug companies might look back fondly at that 13% rating after The Constant Gardener opens in US cinemas on 26 August. The film, based on the eponymous novel by John le Carré, opens with the brutal murder of a young activist, Tessa Quayle (played by Rachel Weisz), in Kenya. Her husband, Justin Quayle (Ralph Fiennes), a member of the British High Commission, is forced to navigate a deadly house of mirrors, and some personal demons, in order to pursue her killers. Along the way, he uncovers diplomatic secrets, corporate conspiracy, … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif [4]: /embed/inline-graphic-4.gif
Errors in Abstract, Figure 1, Table, Conclusion, and Author Contributions
Authors: Peter Groeneveld
Journal: JAMA Cardiology (2018)

Renato D. Lopes, MD, MHS, PhD; Pedro G. M. de Barros e Silva, MD, MHS, PhD; Isabella de Andrade Jesuíno, Pharm; Eliana Vieira Santucci, RT; Lilian Mazza Barbosa, RT; Lucas Petri Damiani, MSc; Renato Hideo Nakagawa Santos, Stat; Ligia Nasi Laranjeira, RT; Frederico Toledo Campo Dall Orto, MD; Pedro Beraldo de Andrade, MD, PhD; Igor Ribeiro de Castro Bienert, MD, PhD; John H. Alexander, MD, MHS; Christopher B. Granger, MD; Otavio Berwanger, MD, PhD
Otolaryngology
Authors: Carlyle G. Flake
Journal: New England Journal of Medicine (1948)

IT IS the purpose of this review to present in summarized form certain papers on subjects of current concern in the field of otolaryngology and others that may be of more general interest. These papers appeared in the literature for the year 1947.The Ear Fenestration Operation Moorhead1 reported a series of 123 patients upon whom the fenestration procedure had been performed. The results were estimated on the basis of audiometer readings taken at 512, 1024 and 2048 cycles. In this group 29 per cent of patients failed to recover satisfactory hearing for any of the three tones. Forty-seven per . . .