tbuckley/cabot-search huggingface dataset:
Abstract 1206: Inhibition of GPR4 attenuates intestinal inflammation in a mouse colitis model
Authors: Edward J. Sanderlin, Mona Marie, Juraj Velcicky, Pius Loetscher, Li V. Yang
Journal: Cancer Research (2019)

Abstract Inflammatory bowel disease (IBD), a chronic inflammatory disorder of the digestive tract, is associated with a higher risk of colorectal cancer development. Current therapeutic approaches for IBD are limited and primarily include biologics and steroids such as anti-TNFα monoclonal antibodies and glucocorticoids. Chronic usage, however, can cause significant adverse drug effects such as increased risk of infection and lymphoma in some patients. GPR4, a pH-sensing G protein-coupled receptor, has recently emerged as a potential therapeutic target for intestinal inflammation. Previous studies demonstrate that GPR4 is a pro-inflammatory receptor expressed in vascular endothelial cells (EC) and stimulates leukocyte-EC adhesion and extravasation. Knockout of GPR4 alleviates intestinal inflammation in IBD mouse models. In this study, we have assessed the effects of a recently developed GPR4 antagonist, 2-(4-((2-Ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)phenyl)-5-(piperidin-4-yl)-1,3,4-oxadiazole (GPR4 antagonist 13, also known as NE 52-QQ57), in the dextran sulfate sodium (DSS)-induced acute colitis mouse model. The GPR4 antagonist 13 inhibited intestinal inflammation. All colitis parameters, such as body weight loss, fecal score, colon shortening, splenic expansion, and mesenteric lymph node enlargement, were reduced in the GPR4 antagonist 13 treatment group compared to the vehicle group. Histopathological features of active colitis and inflammatory gene expression of colon tissues were reduced in the GPR4 antagonist 13 treatment group compared to vehicle control. Our results indicate that the GPR4 antagonist 13 provides a protective effect in the DSS-induced colitis mouse model and inhibition of GPR4 can be explored as a novel anti-inflammatory approach. Citation Format: Edward J. Sanderlin, Mona Marie, Juraj Velcicky, Pius Loetscher, Li V. Yang. Inhibition of GPR4 attenuates intestinal inflammation in a mouse colitis model [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1206.
Lehrbuch der klinischen Untersuchungsmethoden für Studierende und praktische Ärzte.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Low-dose metronomic cyclophosphamide/methotrexate (LDCM) and aspirin for patients without pathologic complete response (pCR) after neoadjuvant treatment for stage II-III breast cancer.
Authors: Susan Burdette-Radoux, Chris E. Holmes, Farrah B. Khan, Kim Dittus, Karen M. Wilson, Marie Wood
Journal: Journal of Clinical Oncology (2013)

163 Background: Patients (pts) who fail to achieve pCR after neoadjuvant chemotherapy have a 20% risk of recurrence at two years. Data for effective postsurgical chemotherapy in this population is lacking. LDCM is an all-oral chemotherapy regimen with anti-angiogenic activity and acceptable toxicity in metastatic breast cancer. Aspirin is associated with a lower risk of breast cancer recurrence in retrospective studies and has anti-angiogenic activity. Here we combine LDCM and aspirin for high risk pts with poor response to neoadjuvant chemotherapy. Methods: Pts with stage II-III HER-2 negative breast cancer who had residual invasive cancer after neoadjuvant chemotherapy were eligible. Pts completed surgery and radiotherapy prior to enrolment and began study treatment within 180 days of surgery. Pts received four 28-day cycles of LDCM (cyclophosphamide 50 mg po daily, and methotrexate 2.5 mg po twice daily on days 1 and 2 each week ). Aspirin 325 mg daily was added on cycles 3 and 4. Pts were evaluated for the primary endpoint of toxicity and safety every 28 days. Secondary endpoint was 2 year relapse free survival. Results: 10 of 13 planned pts were evaluable for toxicity as of May 4, 2013. Pathologic stage ranged from T2N0 to T3N3. 70% of tumors were chemoresistant (stable or upstaged at time of surgery). 60% of pts had hormone receptor positive tumors and received concurrent hormonal therapy. Median age was 59 years (range 38-76). All pts completed 4 cycles of study treatment without dose reduction. There were no grade 3 or 4 related toxicities. Worst hematologic toxicity was grade 2 leukopenia. Worst nonhematologic toxicity was grade 2 fatigue; all other related toxicities were grade 1. 9 pts were evaluable for recurrence and one had recurred at a median followup of 16 months (range 10-26). Conclusions: This antiangiogenic regimen is well tolerated in patients at high risk for recurrence after neoadjuvant chemotherapy, resulting in one recurrence at 16 months median followup, and it may be a candidate for future trials in this setting. Subsequent analyses will include longer term followup and biomarkers for angiogenesis. Clinical trial information: NCT01612247.
Special Articles on Yellow Fever.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Family Practice
Authors: Robert E. Rakel
Journal: JAMA (1985)

Economic 1 Jconomic and political forces are changing the practice of medicine more radically than medical discoveries. Only yesterday, third-party insurers were denying payment for outpatient care, insisting that patients be hospitalized to confirm that they were indeed ill. Physicians were not paid for preventive care or even corrective outpatient services. Such cost-inefficient policies reinforced the trend toward heavy subspecialization; consultants were handsomely rewarded with money and prestige and students discouraged from entering primary care disciplines. Today, outpatient care is "in," expensive hospitalization is "out," and those of us in primary care stifle the temptation to say "I told you so." However, the family physicians needed for cost-effective primary care are not available, and funds for residency programs are being reduced rather than increased. The maldistribution of physician talent over the past 30 years has depleted the primary care ranks such that today the well-trained family physician is one of
Dynamic Psychiatry
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Live, Orally Given Poliovirus Vaccine
Authors: Albert B. Sabin
Journal: JAMA (1984)

IN THE absence of enteric infection with other viruses, the feeding of a single type of live poliovirus vaccine to children who have not previously been infected with the same type of poliovirus usually results in viral multiplication in the intestinal tract, antibody formation, and complete or partial resistance to reinfection. The use of live poliovirus vaccine in areas with climatic and hygienic conditions which permit extensive dissemination of naturally occurring polioviruses and other enteric viruses throughout the year has been complicated by the problem of viral interference,<sup>1</sup>which we have attempted to overcome by the tactics to be described in this communication. The studies of one of us (M.R.-A.) and associates<sup>2</sup>in Mexico and of Plotkin and Koprowski<sup>3</sup>in the Belgian Congo have shown that vaccination programs in large subtropical or tropical cities that are spread out over a period of many weeks and include only
Muscle Abnormalities in Four Patients Taking Statins To Treat Unfavorable Cholesterol Levels
Journal: Annals of Internal Medicine (2002)

Summaries for Patients1 October 2002Muscle Abnormalities in Four Patients Taking Statins To Treat Unfavorable Cholesterol LevelsSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-137-7-200210010-00004 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Statins, also known as HMG coenzyme A reductase inhibitors, are medications commonly used to treat high cholesterol levels. Statins are very effective in getting cholesterol levels into the desired range, and they have had few side effects. However, statins do cause a muscle condition called myopathy. In fact, one statin (cerivastatin) was taken off the market because patients frequently developed myopathy while taking it. Patients with myopathy have muscle tenderness and weakness. Measuring blood levels of the muscle protein called creatine kinase helps doctors to diagnose myopathy because ... Author, Article, and Disclosure InformationThe summary below is from the full report titled “Statin-Associated Myopathy with Normal Creatine Kinase Levels.” It is in the 1 October 2002 issue of Annals of Internal Medicine (volume 137, pages 581-585). The authors are PS Phillips, RH Haas, S Bannykh, S Hathaway, NL Gray, BJ Kimura, GD Vladutiu, JDF England, and the Scripps Mercy Clinical Research Center.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoStatin-Associated Myopathy with Normal Creatine Kinase Levels Paul S. Phillips , Richard H. Haas , Sergei Bannykh , Stephanie Hathaway , Nancy L. Gray , Bruce J. Kimura , Georgirene D. Vladutiu , and John D.F. England , and the Scripps Mercy Clinical Research Center* Metrics Cited bySimvastatin: In Vitro Metabolic Profiling of a Potent Competitive HMG-CoA Reductase Inhibitor 1 October 2002Volume 137, Issue 7Page: I-45KeywordsBlood cellsCholesterolCreatine kinaseMuscle biopsiesMuscle proteinsMusclesMyalgiaPatientsProtein kinasesStatins ePublished: 1 October 2002 Issue Published: 1 October 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
RENAL HYPERTENSION
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tumor DNA content in the prognosis of colorectal carcinoma
Authors: W. Kokal
Journal: JAMA (1986)

Tumor DNA content has been described as having prognostic significance in patients with colorectal carcinoma. It has been unclear, however, whether tumor ploidy as a prognostic factor is independent of various standard prognostic variables such as depth of invasion and lymph node involvement by the tumor. We retrospectively examined 77 patients who were diagnosed between 1974 and 1980 as having had resectable Dukes' stage A, B, or C colorectal carcinomas. The DNA content of each tumor was analyzed by flow cytometry on paraffin-embedded specimens. Both for aneuploid stage B tumors and for the entire group of aneuploid tumors, the disease-free and overall survival times of the patients were significantly shorter than those of patients with diploid colorectal carcinomas. Logistic regression analysis demonstrated that aneuploidy was an independent prognostic variable in predicting recurrent disease as well as death from the colorectal cancer. Tumor ploidy was, in fact, the single most important prognostic factor among all of the clinical and pathologic variables studied. Thus, the DNA content of colorectal carcinoma appears to play an important role in indicating the biologic aggressiveness of the disease. (<i>JAMA</i>1986;255:3123-3127)
Incorrect Word in Abstract and Results
Journal: JAMA Surgery (2014)

and Results sections gave the opposite interpretation of the study's data from the univariate analysis.In the Results portion of the Abstract, "the absence of a faculty mentor" should have appeared as "the presence of a faculty mentor."Likewise, in the Desire to Leave Residency subsection of the Results section, the first sentence of the third paragraph should have appeared as "On univariate analysis, factors that were significantly associated with the consideration to leave residency were older age, female sex, PG year, training in a university program, lack of Alpha Omega Alpha status, and the presence of a faculty mentor (Table 2)."This article was corrected online and in print.Excision of Fibroepithelial Lesions of the Breast Research jamasurgery.com
The Prevailing Pandemic of Influenza
Journal: JAMA (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nucleoli in Lymphocytes in Lymphatic Leukemia and Related Conditions
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Spontaneous bacterial peritonitis and pneumoperitoneum. A false surgical emergency
Authors: G. F. Woelfel
Journal: JAMA (1983)

THE radiological finding of free air within the peritoneal cavity is usually evidence of disease or injury and is best treated by surgical exploration. Spontaneous or primary bacterial peritonitis is a bacterial infection of the peritoneum not associated with underlying surgical disease. Perforated ulcer or intestine, abscess, or penetrating abdominal wound are not factors present as the underlying cause. Spontaneous bacterial peritonitis (SBP) is commonly associated with underlying liver disease, usually cirrhosis with ascites, or the nephrotic syndrome. We describe a patient with cirrhosis with gross ascites and renal failure, who had signs and symptoms of peritonitis and pneumoperitoneum on roentgenogram. At laparotomy, no evidence of gastrointestinal (GI) tract perforation was found. Ascitic fluid culture yielded<i>Clostridium perfringens</i>, suggesting a diagnosis of SBP. <h3>Report of a Case</h3> A 63-year-old man with a long-standing history of alcohol abuse was admitted to the hospital in September 1980 with increasing abdominal girth, increasing
DISEASES FROM VEGETABLES.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Treating Incontinence Electrically
Journal: BMJ (1972)

of outstanding fees should be strengthened and the changes we have already noted with regard to budgetary control and overhead distribution should be incorporated."(ii) The system for computer processing of the register should be modified at the end of the present contract to accommodate a further streamlining of certain clerical tasks."(iii) The Finance Committee's standing orders should be rewritten to provide a more specific definition of its duties and responsibilities and consideration should be given to extending, on a regular basis, the present arrangement for obtaining advice from a qualified accountant."(iv) Further consideration should be given to the possible addition of other sources of revenue as a result of: (a) including a wider range of registered information in the register, and (b) contributions from the central exchequer."(v)