tbuckley/cabot-search huggingface dataset:
IL-12 enhances the natural killer cell cytokine response to Ab-coated tumor cells
Authors: Robin Parihar, Julie Dierksheide, Yan Hu, William E. Carson
Journal: Journal of Clinical Investigation (2002)

The anti-tumor activity of recombinant mAb's directed against tumor cell growth receptors has generally been considered to result from direct antiproliferative effects, the induction of apoptosis, or possibly Ab-dependent cellular cytotoxicity mediated against tumor targets. However, it remains unclear to what degree these mechanisms actually aid in the clearance of Ab-coated tumor cells in vivo. We show here that NK cells secrete a distinct profile of potent immunostimulatory cytokines in response to dual stimulation with Ab-coated tumor cells and IL-12. This response could not be duplicated by costimulation with other ILs and was significantly enhanced in the presence of monocytes. Cytokine production was dependent upon synergistic signals mediated by the activating receptor for the Fc portion of IgG (FcγRIII) and the IL-12 receptor expressed on NK cells. Coadministration of Ab-coated tumor cells and IL-12 to BALB/c mice resulted in enhanced circulating levels of NK cell–derived cytokines with the capacity to augment anti-tumor immunity. These findings suggest that, in addition to mediating cellular cytotoxicity and apoptosis, the anti-tumor activity of mAb's might also result from activation of a potent cytokine secretion program within immune effectors capable of recognizing mAb-coated targets.
Distinct response to platinum-based chemotherapy among patients with metastatic castration-resistant prostate cancer harboring alterations in genes involved in homologous recombination
Authors: L. Fan, X.C. Fei, Y.J. Zhu, C.F. Chi, J.H. Pan, J.J. Sha, Z.X. Xin, Y.M. Gong, X.X. Du, Y.Q. Wang, B.J. Dong, W. Xue
Journal: European Urology (2021)
Error in Figure 2D
Authors: Daniel Spratt, Samir Hanash, Ziding Feng, Ayumu Taguchi
Journal: JAMA Oncology (2019)

Jeanne Tie, MD; Joshua D. Cohen, BS; Yuxuan Wang, PhD; Michael Christie, PhD; Koen Simons, PhD; Margaret Lee, MBBS; Rachel Wong, MBBS; Suzanne Kosmider, MBBS; Sumitra Ananda, MBBS; Joseph McKendrick, MBBS; Belinda Lee, MBBS; Jin Hee Cho, MBBS; Ian Faragher, MBBS; Ian T. Jones, MBBS; Janine Ptak, BS; Mary J. Schaeffer, BS; Natalie Silliman, BS; Lisa Dobbyn, BS; Lu Li, PhD; Cristian Tomasetti, PhD; Nicholas Papadopoulos, PhD; Kenneth W. Kinzler, PhD; Bert Vogelstein, MD; Peter Gibbs, MD
Shelley's 77 skins: A refresher course for doctors, nurses and studentsWalter B. Shelley, MD, and Dorinda Shelley, MD, New York, 2002, CRC Press-Parthenon Publishing. $49.95. 79 pages. ISBN: 1842141066
Authors: T FITZPATRICK, J BERNHARD
Journal: Journal of the American Academy of Dermatology (2004)
Availability and Use of Parenteral Quinidine Gluconate for Severe or Complicated Malaria
Journal: JAMA (2001)

Since 1991, quinidine gluconate, a class 1a anti-arrhythmic agent, has been the only parenteral antimalarial available for use in the United States (1). It is indicated for the treatment of patients with life-threatening Plasmodium falciparum malaria (2), including those who cannot tolerate oral therapy, have high-grade parasitemia, or have complications (e.g., cerebral malaria or acute renal failure).
The Practice of Podiatry.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Chromatin-Remodeling Genes Promote Immunotherapy Resistance
Journal: Cancer Discovery (2018)

Two studies show that genes that encode a chromatin-remodeling complex foster resistance to checkpoint inhibitors. One study identified the proteins by using CRISPR/Cas9 to knock out genes in mouse melanoma cells. The other study converged on the same result by identifying mutations in patients with clear cell renal cell carcinoma who responded to PD-1 inhibitors.
Addictive Drugs and Brain Stimulation Reward
Authors: R. A. Wise
Journal: Annual Review of Neuroscience (1996)

The brain's default mode network consists of discrete, bilateral and symmetrical cortical areas, in the medial and lateral parietal, medial prefrontal, and medial and lateral temporal cortices of the human, nonhuman primate, cat, and rodent brains. Its ...Read More
Lung Structure and Function in Different Stages of Severe Adult Respiratory Distress Syndrome
Authors: Luciano Gattinoni
Journal: JAMA (1994)

<h3>Objective.</h3> —To assess the clinical consequences of duration of adult respiratory distress syndrome (ARDS) on lung structure and function. <h3>Design.</h3> —Retrospective analysis. <h3>Setting.</h3> —A university hospital referral center for extracorporeal support. <h3>Patients.</h3> —A total of 84 patients with severe ARDS (Murray score &gt;2.5) recruited from 48 intensive care units (1979 to 1992), who suffered ARDS and underwent mechanical ventilation for up to 1 week (37 patients with early ARDS), between 1 and 2 weeks (24 patients with intermediate ARDS), or more than 2 weeks (23 patients with late ARDS) and subsequently underwent extracorporeal support. <h3>Main Outcome Measures.</h3> —Before beginning extracorporeal support, we measured gas exchange, pulmonary mechanics, hemodynamics, oxygen transport and delivery, incidence of barotrauma (presence of one or more thoracic tubes for pneumothorax drainage), and organ dysfunctions. In a subgroup of 16 patients, we studied lung structure by computed tomographic scan, scoring the densities and quantifying the emphysemalike lesions (bullae). <h3>Results.</h3> —Late ARDS showed lower respiratory compliance, higher dead space, higher Paco<sub>2</sub>, lower venous admixture, and lower positive end-expiratory pressure requirement compared with early ARDS (<i>P</i>&lt;.01). The incidence of pneumothorax (48.8% of the entire population) was significantly (<i>P</i>&lt;.01) higher in late ARDS (87%) vs intermediate ARDS (46%) and early ARDS (30%). The mortality of patients with pneumothorax (66%) was significantly (<i>P</i>&lt;.01) higher compared with patients without pneumothorax (46%). The number of bullae per lung was significantly higher in late ARDS vs intermediate and early ARDS (mean [SD], 8 [4], 4.3 [5], and 1.9 [3.9], respectively;<i>P</i>&lt;.01 ), and they were preferentially distributed in the dependent lung regions. The number of bullae per lung was significantly higher in patients with pneumothorax vs those without pneumothorax (mean [SD], 13.6 [9.8] vs 1.4 [2.1];<i>P</i>=.007). The mean (SD) duration of ARDS in patients with pneumothorax was 15.3 (10.0) days vs 7.0 (6.6) days in those without pneumothorax (<i>P</i>=.0001). No differences within the three groups were found in computed tomographic scan densities, hemodynamics, and number of organ system dysfunctions. <h3>Conclusions.</h3> —The lung structure and function changes markedly with ARDS duration, and the late stages may be described as restrictive lung disease with superimposed emphysemalike lesions. Presence of pneumothorax affects survival and appears to be related to the lung structural changes occurring with time. (<i>JAMA</i>. 1994;271:1772-1779)
THE KILLING OF DR. DYAS, AND ITS LESSON.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fabry's Disease
Journal: JAMA (1979)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
[623] THE GNB3 C825T POLYMORPHISM AFFECTS RESPONSE TO HCV THERAPY WITH PEGYLATED INTERFERON IN HCV/HIV CO-INFECTED BUT NOT IN HCV MONO-INFECTED PATIENTS
Authors: J. Nattermann, K. Bueren, HD. Nischalke, G. Ahlenstiel, T. Berg, M. Biermer, T. Sauerbruch, M. Vogel, JK. Rockstroh, U. Spengler
Journal: Journal of Hepatology (2007)
The Kidney
Authors: Daniel T. O'Connor
Journal: JAMA (1986)

Soon after I received this two-volume set on nephrology, I assumed the supine position, balancing both volumes on my chest, as I began to flip through the variety of chapters. Immediately, I recognized it would be a formidable task, as judged by the substantial sternal pressure engendered by the volumes. Indeed, the two-volume set weighs a hefty 9 lb. This comprehensive treatise on nephrology is now in its third edition. This edition includes a variety of chapters in these broad categories: "Elements of Normal Renal Function," "Disturbances in the Control of Body Fluid Volume and Composition," "Pathogenesis of Renal Disease," "Pathophysiology of Renal Disease," and "Management of the Patient With Renal Failure." Within each broad category, there are numerous chapters that amply flesh out a variety of topics in nephrologic research and practice. In fact, there are 45 chapters altogether, penned by 87 authors. Within each of the five broad
THE EQUIPMENT OF THE MODERN PHYSICIAN.
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Members of the House of Delegates
Journal: JAMA (1978)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Future Directions for Medical Education
Journal: JAMA (1982)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Antibiotic use at Duke University Medical Center
Authors: M. Castle
Journal: JAMA (1977)

A study of antibiotic use at Duke University Medical Center in June 1973 showed that 34.2% of all patients received antibiotics (43.6% surgical, 21.4% medical patients). Cephalothins were most frequently ordered for surgical patients, ampicillin sodium and penicillin G or penicillin V with potassium for other patients. A retrospective analysis of 50 randomly selected patients, according to the Kunin's categories of use, showed 64% of total antibiotic therapy as not indicated or inappropriately administered in terms of drug or dosage. These results are similar to previous reports of antibiotic surveillance and further establish the need for continuing education of prescribing physicians. (<i>JAMA</i>237:2819-2822, 1977)
NEONATAL NEUROLOGY
Authors: N. B. Capon
Journal: BMJ (1962)

<h3>Abstract</h3> Once considered a uniquely human attribute, behavioral laterality has proven to be ubiquitous among non□human animals, being frequently associated with different neurophenotypes in rodents and fish species. Zebrafish (<i>Danio rerio</i>) are a <b>versatile vertebrate model system</b> that has been widely used in translational neuropsychiatric research due their highly conserved genetic homology, well characterized physiological and extensive behavioral repertoire. Although the spontaneous left- and right-bias responses and associated behavioral domains (e.g. stress reactivity, aggression and learning) have previously been observed in other teleost species, no information regarding <b>how spontaneous motor left-right bias responses of zebrafish predicts other behavioral domains</b> has been described. Thus, we aimed to investigate the existence and incidence of natural left-right bias of adult zebrafish in the Y-maze test and explore any relationship of biasedness on the performance of different behavioral domains. This included learning about threat-cues in the fear conditioning test and locomotion and anxiety-related behavior in the novel tank diving test. In conclusion, we showed for the first time that zebrafish exhibit a natural manifestation of <b>motor</b> behavioral lateralization which can influence aversive learning responses. <b>Although laterality did not change locomotion or anxiety-related behaviors, we found that biased animals had an altered exploration pattern in the Y-maze, making them easily discernable from their unbiased counterparts, and increased learning associated to fear cues.</b>
Queries and Minor Notes
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Continuous emotional support during labor
Authors: Desmond P. J. Barton
Journal: JAMA (1991)

<h3>To the Editor.</h3> — I write concerning the report by Kennell et al<sup>1</sup>regarding the value of emotional support for women in labor that can be provided by a sympathetic and informed female<i>doula</i>. This draws attention to a philosophy of the management of labor to which I had recently been exposed during a 2-year period in the National Maternity Hospital in Dublin, Ireland. Although the probable importance of emotional support in labor provided by a personal attendant seems to have been confirmed in some populations in recent studies,<sup>2</sup>it is not a new concept and, in fact, has been a central feature of the management of labor in the Dublin institution.<sup>3</sup>Reports from the National Maternity Hospital have emphasized the low intervention rate and low cesarean section rate.<sup>4</sup>This management, applicable to nulliparous patients in spontaneous labor with a single gestation and cephalic presentation,<sup>3</sup>
Osteoarthritis Initiative
Authors: Tracy Hampton
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Authors' Reply
Authors: Valeriya Lyssenko, Dragi Anevski, Peter Almgren, Leif Groop
Journal: PLoS Medicine (2006)

I would like to thank PLoS Medicine for publishing Lacasse and Leo's important and methodical Essay that debunks the "chemical imbalance" advertisements for psychiatric drugs [1].Why would the United States Food and Drug Administration (FDA) approve such ads?Our human rights group, MindFreedom International, has been asking that question for a long time.On behalf of MindFreedom, US Senator Ron Wyden contacted the FDA for an explanation about why they approve such advertising.In their responsewhich took over one year to receive-the FDA could cite no scientifi c literature or studies.It turns out there's a good reason that the FDA can't fi nd any scientifi c evidence for the claims of a "chemical imbalance" in these ads: the scientifi c evidence in support of the serotonin hypothesis is very weak.Readers who would like more information about the psychiatric industry's advertising suggesting a "chemical imbalance" in depression may be interested in the following:(1) MindFreedom's debate with Pfi zer, manufacturer of Zoloft, available at http:⁄⁄www.mindfreedom.org/mindfreedom/pfi zerlies.shtml,and (2) a historic debate with the American Psychiatric Association resulting from MindFreedom's 2003 hunger strike, available at http:⁄⁄www.mindfreedom.org/mindfreedom/hungerstrike.shtml