tbuckley/cabot-search huggingface dataset:
Acetaminophen sensitivity and fixed dermatitis
Authors: C. C. Henriques
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Disulfiram treatment of alcoholism. A Veterans Administration cooperative study
Authors: R. K. Fuller
Journal: JAMA (1986)

We conducted a controlled, blinded, multicenter study of disulfiram treatment of alcoholism in 605 men randomly assigned to 250 mg of disulfiram (202 men); 1 mg of disulfiram (204 men), a control for the threat of the disulfiram-ethanol reaction; or no disulfiram (199 men), a control for the counseling that all received. Bimonthly treatment assessments were done for one year. Relative/ friend interviews and blood and urine ethanol analyses were used to corroborate patients' reports. There were no significant differences among the groups in total abstinence, time to first drink, employment, or social stability. Among the patients who drank and had a complete set of assessment interviews, those in the 250-mg disulfiram group reported significantly fewer drinking days (49.0 ±8.4) than those in the 1-mg (75.4±11.9) or the no-disulfiram (86.5 ± 13.6) groups. There was a significant relationship between adherence to drug regimen and complete abstinence in all groups. We conclude that disulfiram may help reduce drinking frequency after relapse, but does not enhance counseling in aiding alcoholic patients to sustain continuous abstinence or delay the resumption of drinking. (<i>JAMA</i>1986;256:1449-1455)
219O Safety and preliminary efficacy of nivolumab in patients with advanced hepatocellular carcinoma: interim analysis of the phase 1/2 CheckMate-040 study
Authors: I. Melero, B. Sangro, T. Yau, C. Hsu, M. Kudo, T. Crocenzi, T.-Y. Kim, S.P. Choo, J. Trojan, T. Meyer, T.H. WellingIII, W. Yeo, A. Chopra, J. Anderson, C. DelaCruz, L. Lang, J. Neely, A. El-Khoueiry
Journal: Annals of Oncology (2016)
GRANULOMA ANNULARE
Authors: E. GRAHAM LITTLE
Journal: British Journal of Dermatology (1908)

Journal Article GRANULOMA ANNULARE Get access E. GRAHAM LITTLE, M.D., F.R.C.P. E. GRAHAM LITTLE, M.D., F.R.C.P. Physician to the Skin Department, St. Mary's Hospital Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 20, Issue 10, 1 October 1908, Pages 317–335, https://doi.org/10.1111/j.1365-2133.1908.tb16532.x Published: 01 October 1908
Withdrawl of a Drug From the Market
Authors: Jere E. Goyan
Journal: JAMA (1993)

In this issue ofTHE JOURNAL, Ross-Degnan et al<sup>1</sup>present a fascinating analysis of the effect of the withdrawal of zomepirac sodium from the market. They note that zomepirac prescribers, faced with withdrawal of the drug from the market, switched, not only to other nonsteroidal anti-inflammatory drugs, but surprisingly to propoxyphene (hydrochloride or napsylate) and barbiturate-containing analgesics. These drugs carry risks that arguably are as serious as those of zomepirac. Based on those findings, they suggest that the risks posed by substituted products be considered before making a decision to withdraw a drug from the market. Although an appealing theoretical concept, it seems unlikely that such a suggestion is of any practicable use. To understand the basis for this statement, it may be instructive to review the bases on which drugs have been withdrawn from the American marketplace in the past 30 years. The largest number of drug products
Epithelioid granulomas in Hodgkin disease. A favorable prognostic sign?
Authors: M. J. O'Connell
Journal: JAMA (1975)

Histologic sections of spleen and liver prepared from tissue obtained during exploratory laparotomy and splenectomy in 91 untreated patients with Hodgkin disease were reviewed to assess the incidence and possible implications of noncaseating, epithelioid, sarcoid-like granulomas. The 17 patients with granulomas and the 74 patients without granulomas did not differ appreciably with respect to pretreatment indexes. All patients were observed for at least 15 months following laparotomy or until the time of death (range, 15 to 67 months; median, 26 months). The 17 patients with granulomas tended to have fewer relapses, longer survival, and lower incidence of subsequent herpes zoster infection compared to the 74 without granulomas. The presence of epithelioid granulomas in association with Hodgkin disease may reflect a host response to the tumor with favorable prognostic implications. (<i>JAMA</i>233:886-889, 1975)
Abstract 3567: A novel E2F1-regulated lncRNA, XLOC_000190, is required for S phase progression and cell proliferation
Authors: Doron Ginsberg, Tali Nizri-Megnaji, Esther Baruch
Journal: Cancer Research (2019)

Abstract Long non-coding RNAs (lncRNAs) are major regulators of many cellular processes including cell cycle progression and cell proliferation. The pivotal transcription factor E2F1 induces both proliferation and cell death and is a critical downstream target of the tumor suppressor RB. The RB/E2F pathway is often inactivated in human tumors resulting in deregulated E2F activity. Here, we report that the human lncRNA XLOC_000190 is an E2F1- regulated lncRNA that plays a role in S phase progression. XLOC_000190 levels are elevated upon activation of E2F1. Furthermore, knockdown of E2F1 and E2F3 reduce XLOC_000190 levels and endogenous E2F1 binds the XLOC_000190 promoter. Moreover, expression of XLOC_000190 is cell cycle regulated and peaks near G1/S transition and in early S. Inhibition of XLOC_000190 expression increases percentage of S phase cells, suggesting that XLOC_000190 plays a role in S phase progression. Also, silencing of XLOC_000190 in cells that are synchronized at the G1/S delays progression of cells through S phase. In agreement with its suggested role in S phase, prolonged silencing of XLOC_000190 inhibits proliferation of human cancer cells in culture. XLOC_000190 is a nuclear lncRNA and its gene is localized downstream to the protein-coding gene CDKN2C that encodes the p18ink4c CDK inhibitor. In search for XLOC_000190 mode of action we do not detect any changes in the expression of this neighbor upon XLOC_000190 silencing. However, XLOC_000190 silencing leads to a significant decrease in the level of Ribonucleotide Reductase Regulatory Subunit M2 (RRM2), which is a critical player in S phase progression. Additional data indicate that RRM2 mediates, at least in part, the effect of XLOC_000190 on S phase progression. Importantly, low levels of XLOC_000190 are associated with increased survival of kidney cancer patients. In conclusions, our data identify XLOC_000190 as a novel E2F-regulated lncRNA that has a potential role in human cancer and regulates cell-cycle progression and cell proliferation, at least in part, via regulation of RRM2. Citation Format: Doron Ginsberg, Tali Nizri-Megnaji, Esther Baruch. A novel E2F1-regulated lncRNA, XLOC_000190, is required for S phase progression and cell proliferation [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3567.
A Study of the Bacteria Which Survive Pasteurization.
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Re: K. Hatzimouratidis, I. Eardley, F. Giuliano, I. Moncada, A. Salonia. Guidelines on Male Sexual Dysfunction: Erectile Dysfunction and Premature Ejaculation. European Association of Urology Web site. http://uroweb.org/guideline/male-sexual-dysfunction/. Updated 2015
Authors: Pero Bokarica
Journal: European Urology (2015)
Recherches Cliniques et Therapeutiques sur L'Epilepsie, L'Hysterie, et L'Idiotie. Compte-rendu du Service des Enfants Idiots, Epileptiques et Arriérés de Bicêtre Pendant L'Année 1900. Par Bourneville avec in collaboration de MM. Crouzon. Dionis de Séjour, Izard, Laurens, Paul-Boncour, Philippe et Oberthur.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Emperor's New Clothes
Authors: Faith T Fitzgerald
Journal: Annals of Internal Medicine (2012)

On Being a Doctor6 March 2012The Emperor's New ClothesFaith T. Fitzgerald, MDFaith T. Fitzgerald, MDFrom University of California, Davis, Medical Center, Sacramento, CA 95817.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-156-5-201203060-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail In his famous story, “The Emperor's New Clothes,” Danish author Hans Christian Andersen tells of an emperor, vain and pompous, who is scammed by rogues who tell him that that they can weave him royal regalia made of a cloth so exquisite and fine that no one can see it but the most competent and intelligent of persons.When the scoundrels mime draping him in this miraculous fabric, he stands naked, but no one—including the emperor himself—dare say so, for fear that they will be thought to be stupid and inept. It isn't until the Emperor parades proudly through the ... Author, Article, and Disclosure InformationAffiliations: From University of California, Davis, Medical Center, Sacramento, CA 95817.Corresponding Author: Faith T. Fitzgerald, MD, University of California, Davis, Medical Center, Division of General Medicine, 4150 V Street, Suite 2400, Sacramento, CA 95817; e-mail, [email protected]ucdavis.edu. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 6 March 2012Volume 156, Issue 5Page: 396-397KeywordsEmergency departmentFearHospitalizationsInpatientsKneesNursesOrthopedicsScarsSurgeryTouch ePublished: 6 March 2012 Issue Published: 6 March 2012 Copyright & PermissionsCopyright © 2012 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
A Randomized Controlled Trial Using Glycemic Plus Fetal Ultrasound Parameters Versus Glycemic Parameters to Determine Insulin Therapy in Gestational Diabetes With Fasting Hyperglycemia
Authors: Apolonia García-Patterson, Rosa Corcoy, Montse Balsells, Orenci Altirriba, Juan María Adelantado, Lluís Cabero, Alberto de Leiva
Journal: Diabetes Care (2002)
The hidden threat of hepatitis B
Authors: None The Lancet Global Health
Journal: The Lancet Global Health (2016)

July 28 is World Hepatitis Day—a time to "join together to make the elimination of viral hepatitis our next greatest achievement". Hepatitis is, belatedly, beginning to nudge its way into the global awareness. Having been neglected entirely in the Millennium Development Goals, it gets a name-check alongside AIDS, tuberculosis, and malaria within Sustainable Development Goal target 3.3, and—at the World Health Assembly in May this year—the first Global Health Sector Strategy on Viral Hepatitis was endorsed.
The changing pattern of hypertension and the declining incidence of stroke
Authors: W. M. Garraway
Journal: JAMA (1987)

We studied whether changes in recognition and control of hypertension could be detected in the population of Rochester, Minn, from 1950 to 1979, a period in which a major decrease in the incidence rate of stroke was observed. Prevalence of diastolic blood pressure greater than or equal to 105 mm Hg fell 26% and 70% in men and women, respectively, between 1950 to 1959 and 1970 to 1979. Prevalence of pressures greater than or equal to 95 mm Hg decreased 5% in men and 58% in women. Increasing control of hypertension had an almost inverse linear relationship with the decreasing incidence of stroke in women, but the incidence of stroke in men did not decrease until ten years after improvement in the control of blood pressure began. We conclude that improvements in the detection and control of hypertension contributed to the declining incidence of stroke and that differences in management of hypertension could account for the difference between men and women in the trend of stroke decline. (<i>JAMA</i>1987;258:214-217)
"WASHINGTON'S DEATH AND THE DOCTORS."
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ENDOMETRIOSIS
Authors: ARTHUR L. HASKINS
Journal: Annals of Internal Medicine (1958)

Editorial1 April 1958ENDOMETRIOSISARTHUR L. HASKINS, M.D.ARTHUR L. HASKINS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-48-4-909 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe escape of endometrial tissue from the confines of the uterus to contiguous pelvic structures results in pelvic endometriosis. This progressively incapacitating disease is characterized by its histologic resemblance to normal endometrial tissue and by a potentially invasive and malignant clinical course. The ravages of this process with involvement and perforation of hollow viscera may result in death. As a minimum, endometriosis will seriously interfere with reproductive function.The etiology of pelvic endometriosis has long been an important point of discord among gynecologists. The proponents of the retrograde flow, metaplasia, and embryologic rest theories have defended their own concepts and... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ARTHUR L. HASKINS, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1958Volume 48, Issue 4Page: 909-912KeywordsEtiologyProgressive diseasesUterus ePublished: 1 December 2008 Issue Published: 1 April 1958 PDF downloadLoading ...
Errors in Table Headings
Authors: Christine Jones
Journal: JAMA Internal Medicine (2019)

Daniel J. Buysse, MD; Anne Germain, PhD; Douglas E. Moul, MD, MPH; Peter L. Franzen, PhD; Laurie K. Brar, MSN; Mary E. Fletcher, BS; Amy Begley, MA; Patricia R. Houck, MSH; Sati Mazumdar, PhD; Charles F. Reynolds III, MD; Timothy H. Monk, DSc, PhD
The Consequences of Uncertainty
Authors: Allen F. Fischer
Journal: JAMA (1987)

BEFORE being struck down, the "Baby Doe" rule generated intense debate among those individuals who were interested in the ethical underpinnings of neonatal intensive care.<sup>1</sup>The enormity of the gap between the attempt to regulate physician behavior and the reality in which such regulation was to occur was reflected in the implicit anonymity of the designation, Baby Doe. The treatment of many different conditions affecting individual patients could not possibly be regulated by a few general directives based on the anticipated outcome for the entire group. The ability to predict outcomes for individual, severely disabled infants is limited, even with precise knowledge of the infant's condition at birth. To understand the difficulty in making decisions regarding the care of extremely premature neonates, it is imperative to understand the complex professional charge of the physician. As set forth in the Hippocratic tradition, the charge has two parts. The first is
Amer J of Roentgenology, Springfield, Ill
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Establishing the diagnosis of benign familial hematuria. The importance of examining the urine sediment of family members
Authors: S. S. Blumenthal
Journal: JAMA (1988)

Patients with microscopic hematuria are generally referred for urologic investigation. We describe 30 patients with normal renal function referred to our clinic during the years 1970 through 1987 for evaluation of hematuria, usually microscopic, in whom prior urologic and radiological studies had failed to determine the cause of bleeding. Urinary sediment from the patients and first-degree relatives revealed hemoglobin and red blood cell casts; the inheritance pattern was consistent with autosomal dominant transmission. During follow-up for up to 18 years, renal function remained normal, thus confirming the diagnosis of benign familial hematuria. Immunoglobulin A nephropathy and Alport's syndrome were less common than benign familial hematuria and could be differentiated from it by history, physical examination, and routine laboratory testing. Since benign familial hematuria is a common disorder in adults with hematuria and normal renal function, urinary sediment from patients and family members should be examined before extensive urologic and radiological procedures are performed. (<i>JAMA</i>1988;259:2263-2266)
Escitalopram Treatment of Generalized Anxiety Disorder in Older Adults—Reply
Authors: Eric J. Lenze
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal