tbuckley/cabot-search huggingface dataset:
Detection of cell-CAM 105 in the pericanalicular domain of the rat hepatocyte plasma membrane
Authors: J Mowery
Journal: Hepatology (1991)

Cell-CAM 105 has been identified as a cell adhesion molecule based on the ability of anti-cell-CAM 105 monospecific Fab fragments to inhibit the reaggregation of rat hepatocytes. Because of its adhesive properties, it was expected that cell-CAM 105 would be present on the lateral cell surface where adhesive interactions predominate. Paradoxically, however, immunofluorescence analysis of frozen sections of rat liver using specific monoclonal antibodies indicated that cell-CAM 105 was present exclusively in the bile canalicular domain of the rat hepatocyte where there is no intercellular adhesion. To more precisely define the in situ localization of cell-CAM 105, immunoperoxidase labeling and electron microscopy were used to examine intact and mechanically dissociated liver tissue. Results showed that when accessibility was provided by mechanical dissociation of perfusion fixed liver tissue, cell-CAM 105 could be detected in the pericanalicular region of lateral membranes. In contrast, when hepatocytes were labeled after incubation in vitro under conditions used during adhesion assays to induce reaggregation, cell-CAM 105 rapidly redistributed to all areas of the plasma membrane. Immunofluorescence analysis of primary hepatocyte cultures further revealed that cell-CAM 105 and two other bile canalicular proteins relocalized to discrete domains reminiscent of bile canaliculi, whereas cell-CAM 105 was also present in areas of intercellular contact. Serial section electron microscopy analysis of well-defined, cross-sectional profiles of bile canaliculi suggested the presence of cell-CAM 105—positive membrane folds that extended along the length of the bile canalicular border. In sections from livers in which calcium-dependent adhesive contacts had been disrupted by treatment with ethylenediamine tetraacetate, intact bile canaliculi were found that remained attached only by these border folds. The implications of these results are discussed with regard to a possible role for cell-CAM 105 in bile canalicular formation. (HEPATOLOGY 1991; 13:47–56).
Cadmium from Soil Amended with Sewage Sludge: Effects and Residues in Swine
Authors: L. G. Hansen, T. D. Hinesly
Journal: Environmental Health Perspectives (1979)

Liquid digested sewage sludge from a Chicago waste treatment plant was applied to experimental corn plots starting in 1968. The treatment plant received a high proportion of industrial effluent and the sludge averaged about 200 ppm Cd (dry weight). Corn grain harvested from the plots in 1974 was fed to growing swine for 56 days, and other swine were permitted to forage on the plots during the winters of 1975-76 and 1976-77. The sludge-fertilized corn contained higher concentrations of nutrient and toxic elements, but did not interfere with swine performance. Minor changes in hepatic microsomal oxidases and red blood cells accompanied significant increases in renal Cd and decreases in hepatic Fe. Swine foraging on these plots ingested considerable amounts of sludge soil and accumulated significantly higher concentrations of renal Cd. At lower rates of sludge application the swine outperformed those foraging both on control plots and those receiving heavy sludge applications in terms of weight gain, in-utero piglet survival, blood hemoglobin, and tissue Fe concentrations.
Clinical impact of the predict prostate risk communication tool in men newly diagnosed with non-metastatic prostate cancer: A multi-centre randomised controlled trial
Authors: D. Thurtle, V. Jenkins, A. Freeman, M. Pearson, G. Recchia, P. Tamer, K. Leonard, P.D. Pharoah, J. Aning, S. Madaan, C. Goh, S. Hilman, S. Mccracken, C. Ilie, H. Lazarowicz, V. Gnanapragasam
Journal: European Urology (2021)
Gynecology
Authors: Howard G. McQuarrie
Journal: JAMA (1979)

<h3>Endoscopy</h3> Historically, the endoscopic inspection of the body cavities, particularly cystoscopy, dates from the turn of the century. Abdominal cystoscopy by Trendelenburg positioning and gaseous distension was described in 1911, and gradual improvement continued until about 20 years ago, when culdoscopy and laparoscopy came into wide use with the perfection of techniques and instrumentation. Cold illumination opened new areas to direct inspection, and light conducted along quartz rods and flexible fiberglass guides made possible the design of equipment with great diagnostic and therapeutic potential. Gynecologists have long been aware of the limitations of clinical pelvic evaluation using speculums and vaginal and abdominal palpation. Endoscopy offers advantages of magnified inspection, biopsy, and aspiration for bacterial and cytological investigation.<sup>1</sup>Limited operations can be done such as sterilization by division or coagulation of the uterine tubes, lysis of pelvic adhesions, removal of a displaced intrauterine contraceptive device, and, recently, recovery of viable
Erratum to First <i>de novo</i> mutation in <i>RPS19</i> gene as the cause of hydrops fetalis in Diamond–Blackfan anemia
Authors: Lydie Da Costa, Genevieve Chanoz-Poulard, Maud Simansour, Martine French, Raymonde Bouvier, Fabienne Prieur, Nathalie Couque, Anne Lise Delezoide, Thierry Leblanc, Narla Mohandas, Renaud Touraine
Journal: American Journal of Hematology (2013)
From the Food and Drug Administration
Authors: Stuart L. Nightingale
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AIR RAID HYPOIMMUNITY
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
JAPAN
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Adaptive Evolution Database (TAED)
Authors: David A Liberles, David R Schreiber, Sridhar Govindarajan, Stephen G Chamberlin, Steven A Benner
Journal: Genome biology (2001)

The Master Catalog is a collection of evolutionary families, including multiple sequence alignments, phylogenetic trees and reconstructed ancestral sequences, for all protein-sequence modules encoded by genes in GenBank. It can therefore support large-scale genomic surveys, of which we present here The Adaptive Evolution Database (TAED). In TAED, potential examples of positive adaptation are identified by high values for the normalized ratio of nonsynonymous to synonymous nucleotide substitution rates (KA/KS values) on branches of an evolutionary tree between nodes representing reconstructed ancestral sequences.Evolutionary trees and reconstructed ancestral sequences were extracted from the Master Catalog for every subtree containing proteins from the Chordata only or the Embryophyta only. Branches with high KA/KS values were identified. These represent candidate episodes in the history of the protein family when the protein may have undergone positive selection, where the mutant form conferred more fitness than the ancestral form. Such episodes are frequently associated with change in function. An unexpectedly large number of families (between 10% and 20% of those families examined) were found to have at least one branch with high KA/KS values above arbitrarily chosen cut-offs (1 and 0.6). Most of these survived a robustness test and were collected into TAED.TAED is a raw resource for bioinformaticists interested in data mining and for experimental evolutionists seeking candidate examples of adaptive evolution for further experimental study. It can be expanded to include other evolutionary information (for example changes in gene regulation or splicing) placed in a phylogenetic perspective.
Congenital Club-Foot (Talipes Equinovarus).
Journal: JAMA (1930)

Congenital clubfoot is a common condition. The causes and treatment are still under discussion. The author presents the various theories of etiology. He believes that the cause is a failure of development of the structures of the foot independent of any extrinsic influences. This results in subluxation of the astragalocalcaneoscaphoid joint and shortening of the muscles that control the socket for the head of the astragalus. He describes pathology, anatomy and various types of deformity. The treatment of various types and at different ages is discussed. The subject matter is well chosen and the sequence is excellent. The illustrations are well selected and executed. There is a disagreement with the author's position concerning early treatment. It is a book that should be read by every orthopedic surgeon and can be read by the obstetrician and general practitioner with benefit. This book was awarded the Robert Jones gold medal given by
MicroRNA Signatures in Human Ovarian Cancer
Authors: Marilena V. Iorio, Rosa Visone, Gianpiero Di Leva, Valentina Donati, Fabio Petrocca, Patrizia Casalini, Cristian Taccioli, Stefano Volinia, Chang-Gong Liu, Hansjuerg Alder, George A. Calin, Sylvie Ménard, Carlo M. Croce
Journal: Cancer Research (2007)

Abstract Epithelial ovarian cancer (EOC) is the sixth most common cancer in women worldwide and, despite advances in detection and therapies, it still represents the most lethal gynecologic malignancy in the industrialized countries. Unfortunately, still relatively little is known about the molecular events that lead to the development of this highly aggressive disease. The relatively recent discovery of microRNAs (miRNA), a class of small noncoding RNAs targeting multiple mRNAs and triggering translation repression and/or RNA degradation, has revealed the existence of a new level of gene expression regulation. Multiple studies involving various types of human cancers proved that miRNAs have a causal role in tumorigenesis. Here we show that, in comparison to normal ovary, miRNAs are aberrantly expressed in human ovarian cancer. The overall miRNA expression could clearly separate normal versus cancer tissues. The most significantly overexpressed miRNAs were miR-200a, miR-141, miR-200c, and miR-200b, whereas miR-199a, miR-140, miR-145, and miR-125b1 were among the most down-modulated miRNAs. We could also identify miRNAs whose expression was correlated with specific ovarian cancer biopathologic features, such as histotype, lymphovascular and organ invasion, and involvement of ovarian surface. Moreover, the levels of miR-21, miR-203, and miR-205, up-modulated in ovarian carcinomas compared with normal tissues, were significantly increased after 5-aza-2′-deoxycytidine demethylating treatment of OVCAR3 cells, suggesting that the DNA hypomethylation could be the mechanism responsible for their overexpression. Our results indicate that miRNAs might play a role in the pathogenesis of human EOC and identify altered miRNA gene methylation as a possible epigenetic mechanism involved in their aberrant expression. [Cancer Res 2007;67(18):8699–707]
Medical grand rounds at Hopkins
Authors: J. D. Stobo
Journal: JAMA (1989)

With this issue,The Journalcommences publication of selected case discussions from medical grand rounds at The Johns Hopkins Hospital, Baltimore, Md.<sup>1</sup>Case discussions as a form of teaching began with William Osier and have continued at Hopkins.<sup>2</sup>Osler performed rounds in the clinic on patients he had never seen before; he took a history and did a physical examination on the spot, and he said whatever he wished about them, drawing on his immense personal experience and his encyclopedic knowledge of the literature in three languages. Usually what Osier had to say was remarkably shrewd. Of course, he was in a somewhat privileged position: if Osler said the diagnosis was typhoid, no intern was going to quibble about the negative Widal's reaction. With time, people who could discuss anything at a moment's notice became scarce, and rounds changed. The venue was moved from the clinic to an
CONCERNING THE SO-CALLED APOPLEXY OF THE UTERUS.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The closing of Shasta General Hospital
Authors: P. A. Pugno
Journal: JAMA (1991)

<h3>In Reply.—</h3> The letter by Pugno et al highlights the value of multiple perspectives in evaluating policy changes. While they did not perceive a change in the availability of health care services in Shasta County after the public hospital closed, the patients who used that hospital provided a very different opinion. Physicians' and administrators' opinions do not substitute for the patients' point of view. Pugno et al assert that we did not communicate with them in performing our evaluation. In fact, we consulted with many of Shasta County's health care providers and community leaders and the chief executive officers of Mercy Medical Center and Redding Medical Center, and the county health officer and the state assemblyman from Shasta wrote letters to support our proposal to funding agencies. We were aware of the transition of the Family Practice Residency from Shasta General Hospital to Mercy Medical Center and hoped that this
THE FUNCTION OF THE CECUM AND APPENDIX.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Congressional Testimony on Senate Bill S. 1804
Authors: Otis R. Bowen
Journal: JAMA (1987)

LET ME begin by commending Senator Orrin Hatch (R-Utah), the sponsor of S. 1804. This distinguished senator's diligent work on this and other legislation is deserving of the highest plaudits. We owe him our deepest thanks and appreciation. I appreciate the opportunity to testify on the issue of health care liability. As a physician, former state legislator, governor, and now Secretary of Health and Human Services, this issue has been of continuing concern to me, and it should be of great concern to every American. We know that malpractice has meant increased liability costs to health care providers. We know that these escalating costs cause insurance companies to increase premiums, and sometimes withdraw liability insurance. We know that physicians believe they are increasingly and unfairly at risk of being sued. And, at the same time, we know that it is the right of every person to gain redress if they
Abstract 14342: Relationship Between Peri-Strut Low Intensity Areas and Vascular Healing Response After Everolimus-Eluting Bioresorbable Scaffold Implantation: an Optical Coherence Tomography Study
Authors: Takao Sato, Mohamed Abdel-Wahab, Mohamed El-Mawardy, Ralph Tölg, Gert Richardt
Journal: Circulation (2015)

Objects: Peri-strut low intensity areas (PLIA) surrounding stent struts on optical coherence tomography (OCT) images has been histologically related to the delayed healing and inflammation, and have been previously associated with neointimal proliferation particularly in first generation drug-eluting stent era. However, the relationship between PLIA and bioresorbable vascular scaffolds (BRS) implantation remains to be clarified. Methods: Of 149 patients treated with the everolimus-eluting BRS at a single institution and followed-up for at least 6 months, 38 patients (50 lesions) underwent follow-up coronary angiography including OCT 11.0 ± 2.1 months after BRS implantation. All patients were prescribed lifelong aspirin (100mg/d) and prasugrel (10mg/d) for at least 6 months. The mean- and percent- neointimal area were evaluated by OCT. PLIA was defined as a peri-strut region with a homogenous lower intensity appearance than the surrounding tissue on OCT images without significant signal attenuation and was graded as follows:grade 0, no PLIA; grade 1, &lt;1 quadrant; grade 2, ≥1 but &lt;2 quadrants; grade 3, ≥2 quadrants but &lt;3 quadrants; and grade 4, ≥ 3 quadrants. Additionally, all patients were divided into two groups (PLIA+ group, N=35 and PLIA- group,N=15). Results: The frequency of any PLIA within the scaffold segment was 70.0% (35/50 scaffolds). Mean PLIA grade score was 0.72± 0.77 [Median value (interquartile range), 0.51 (0, 1.07)]. There were significant positive correlations between PLIA score and both mean- (R=0.55,p&lt;0.01) and percent- neointimal area (R=0.58,p&lt;0.01). Both mean- and percent- neointimal area were significantly higher in the PLIA+ group than in the PLIA- group (1.95±0.65 vs. 1.51±0.27 mm 2 , p&lt; 0.01 and 24.0±7.0 vs. 17.4±3.6 %, p&lt; 0.01, respectively).Furthermore, when lesions were divided in 3 groups (group of PLIA score 0, N=15; group of 0&lt;PLIA score&lt;1, N=20; group of 1 &lt; PLIA score, N=15), mean- and percent- neointima area were different among 3 groups (1.51±0.27 vs.1.66±0.39 vs.2.39±0.73 mm 2 , p&lt;0.01; 17.4±3.7 vs.21.6±5.0 vs. 27.4±8.1 %, p&lt;0.01). Conclusion: The presence and extent of PLIA after BRS implantation on OCT imaging appeared to be significantly associated with neointimal formation.
Diverse approaches to new therapies may hold promise in multiple sclerosis
Authors: C. A. Raymond
Journal: JAMA (1986)

"WE ARE GROPING in the dark, working at the edges of the problem," admits Gary Birnbaum, MD, associate professor of neurology, University of Minnesota Medical School, Minneapolis. "The problem" is multiple sclerosis. It is the most common degenerative inflammatory neurological disease to strike people of working age (15 to 55 years)—an estimated 150 000 in the United States—according to a spokesperson at the National Institute of Neurological and Communicative Disorders and Stroke. Although clinical features were described more than 100 years ago by the 19th century Paris neurologist Jean Martin Charcot, its causes and cure remain elusive. Birnbaum's comment about multiple sclerosis was echoed by many of the physicians and other medical scientists at the American Academy of Neurology meetings in New Orleans. They are all too familiar with the scores of promising therapies that ultimately proved ineffective. What is more, even though there are probably more well-designed clinical trials