tbuckley/cabot-search huggingface dataset:
THE ANTITOXIC PROPERTIES OF THE BLOOD OF CHOLERA CONVALESCENTS.
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fatal hand-foot-and-mouth disease in an adult caused by Coxsackievirus 47
Authors: D. A. Baker
Journal: JAMA (1979)

HAND-foot-and-mouth disease occurs almost exclusively in children and is usually benign and self-limited. It is caused primarily by coxsackievirus A16,<sup>1</sup>although coxsackieviruses A5, A9, and A10 have also been implicated.<sup>2,3</sup>We recently treated a woman who had classic hand-foot-and-mouth disease, which then progressed to pancarditis and fatal pneumonia. The causative agent was coxsackievirus A7. <h3>Report of a Case</h3> A 29-year-old woman was admitted to the Medical Center Hospital of Vermont with fever, a maculopapular rash on her arms and legs, a sore throat with small vesicles on the pharynx, vesicles on the vaginal mucosa, and abdominal pain. Her illness had begun two days earlier, with pleuritic discomfort exacerbated by deep breathing. The next day a papular rash appeared on her arms and legs. The pleuritic pain worsened, she became febrile, and she noted conjunctival redness. The papular rash had progressed, becoming papulovesicular and involving her thighs, hands, and
Economics
Authors: Uwe E. Reinhardt
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue Access Provided by Korea University Medical Library JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account
Highlights
Journal: JAMA (2018)

Supervised treadmill exercise improves walking performance in patients with lowerextremity peripheral artery disease, but patients may fi nd it burdensome to attend an exercise center.In a trial that randomized 200 patients with peripheral artery disease, McDermott and colleagues found no improvement in walking performance for a home-based exercise intervention that included a wearable activity monitor and telephone coaching. CME jamanetwork.com/learning Antiplatelet Therapy After Coronary Artery Bypass Grafting 1677Antiplatelet therapy improves saphenous vein graft patency and decreases the rate of major adverse cardiac events, but it is unclear whether dual antiplatelet therapy provides additional benefi t.Zhao and colleagues randomized 500 patients with indications for elective coronary artery bypass grafting and found that ticagrelor plus aspirin signifi cantly increased graft patency vs aspirin alone.In an Editorial, Alexander anticipates that ongoing trials will clarify the eff ects of dual antiplatelet therapy on clinical outcomes such as ischemic events and bleeding.
JKB-122 in subjects with non-alcoholic fatty liver disease (NAFLD): a phase 2, randomized, multiple-dose, double-blind, placebo-controlled study
Authors: Kuo-Chin Huang, Ming-Yao Chen, Chih-Lin Lin, Sien-Sing Yang, Chao-Wei Hsu, Chia-Chi Wang, Yi-Hsiang Huang, Chun-Chao Chang, Ying-Chu Shih, Sheng-Hung Liu
Journal: Journal of Hepatology (2020)
The Self-Assessment Test
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Congenital varicella.
Authors: I Alexander
Journal: BMJ (1979)

a week after my own report.In other words, I'm afraid, Now!, quite legitimately, "scooped" the Lancet on its own territory on this occasion.Although it verges on pedantry to expect a lay publication like Now! to be as scrupulous as a relatively academic joumal such as the BMJ in quoting recondite sources, I entirely agree that sources should be quoted.We will always give credit where it is due, and I hope the BMJ will try harder in future to do the same.
Atypical measles 14 years after immunization
Authors: E. J. Haas
Journal: JAMA (1976)

ATYPICAL measles is a term used to describe the bizarre clinical manifestations of natural measles infection in children who previously received killed measles virus vaccine.<sup>1</sup>The syndrome consists of a two- to three-day prodrome of fever, headache, malaise, and cough, followed by a maculopapular rash that begins on the wrists and ankles. The rash has vesicular, urticarial, and petechial components; spreads to involve the palms, soles, and trunk; and fades after approximately one week. Peripheral edema and roentgenographic evidence of pneumonitis occur in all children reported. In about one half, pleural effusions develop. The white blood cell and differential cell counts are variable. A similar but less severe illness develops in those immunized with attenuated measles vaccine.<sup>2</sup> The following case shows that atypical measles can be seen many years after immunization. Postinfectious arthralgias may be part of the syndrome. <h3>Report of a Case</h3> In a previously well 17-year-old
Cardiac Resuscitation: Combined Use of External Cardiac Massage, External Cardiac Defibrillation, and External Electric Cardiac Stimulation
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Methadone Substitution
Authors: Charles M. White
Journal: JAMA (1972)

<h3>To the Editor.—</h3> With reference to "Dope Fiend to Drug Addict," (Dr. William Stead's letter in the Sept 4, 1972, issue ofThe Journal), I would like to comment. I agree that substitution of methadone is not the solution and that the heroin problem is only a symptom. However, methadone programs at this time appear to be an easement. The addict population in general may be suffering from identity crisis problems. Perhaps in attempting to evolve a "mature self," they treat themselves to a feeling pleasure state with drugs. The teenage "trying on of different hats" achieves the solution when an individual finds the one that fits. Now if we adults can weather the fad and provide stable reference points, such as methadone assistance programs, the drug abuser may survive long enough to work through his real problems and become a "productive member of society." I view the methadone substitution
Growth of the Experimental Method
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
More About Second Cancers After Retinoblastoma
Authors: Anna T. Meadows, Ann M. Leahey
Journal: JNCI Journal of the National Cancer Institute (2008)

In 1973, Strong and Knudson ( 1 ) predicted that second cancers would occur at an increased rate in survivors of retinoblastoma, that only those with the genetic form of the tumor would be at risk, and that radiation therapy (RT) would increase the risk.Beginning with a report from the Late Effects Study Group in which retinoblastoma emerged as the most common primary cancerit occurred in 52 of 292 children with more than one malignant disease ( 2 ) -many other cohort studies have confirmed this increased risk ( 3 -8 ).The genetic form of the disease includes all children with bilateral disease (although the majority have a negative family history and are due to new germline mutations), patients with unilateral disease and a positive family history, and patients in whom genetic analysis has confirmed a mutation in RB1.Because genetic analysis of RB1 was performed in some members of the cohort described by Marees et al. ( 10 ) in this issue of the Journal, it would be interesting to know how many unilateral cases were added to the genetic list based on mutation analysis.Marees et al. provide follow-up of the Dutch cohort in their earlier report with additional data ( 9 , 10 ).With almost 700 case subjects followed up for a median of 22 years, they report an elevated risk of second cancers in 298 hereditary cases: 38 % at 50 years from diagnosis.This is similar to the 36% risk at 50 years reported by Kleinerman et al. ( 3 ) whose report was based on almost 1600 cases (of which 936 were hereditary).Both this study and that by Kleinerman et al. found a threefold increased risk for irradiated patients compared with nonirradiated patients with
Abstract 1656: Systematic identification of cancer therapeutic liabilities through adaptive functional proteomics
Authors: Jun Li, Wei Zhao, Yiling Lu, Gordon B. Mills, Han Liang
Journal: Cancer Research (2019)

Abstract Reverse-phase protein arrays (RPPAs) offer a powerful functional proteomic approach to evaluate biomarkers and mechanisms underlying sensitivity and resistance to cancer therapy. This rapidly maturing quantitative antibody-based assay can assess a large number of protein markers in many samples in a cost-effective, sensitive and high-throughput manner. MD Anderson Cancer Center has been a leader in the technology, and our platform currently contains ~300 protein markers, covering all major signaling pathways. We have generated and compiled the RPPA data of cell lines that were treated with &amp;gt;150 compounds under multi-dosage, replicates or triplicates up to 8 time points in 2D/3D cell culture. In total, we have &amp;gt;25,000 perturbed samples profiled using our RPPA platform. From these adaptive RPPA data, we developed computational algorithms to infer therapeutic liabilities including synthetic lethality and related combined therapies in a systematic way. Representative examples include PARP and MEK inhibitor combination showing synergistic activities in RAS mutant tumors. We further built an integrated data portal that contains user-friendly analytic and visualization tools for a broad biomedical community to utilize these data. Citation Format: Jun Li, Wei Zhao, Yiling Lu, Gordon B. Mills, Han Liang. Systematic identification of cancer therapeutic liabilities through adaptive functional proteomics [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1656.
Organization Section
Authors: Thaddeus Danowski
Journal: Diabetes Care (1988)

A specialist in internal medicine, Dr. Danowski devoted his career to studying the problems of weight reduction and diabetes control.Dr. Danowski conducted a 14-yr study on diabetes that explored whether control of diabetes prevented further complications of the disease.He wrote extensively about body fluids and electrolyte balance, diabetes, endocrinology, and calcium and phosphorus balance at it related to parathyroid and bone.His publications cover many aspects of medicine, physiology, biochemistry, metabolism, endocrinology, and psychology.Some of his major books on endocrinology are standard textbooks for medical schools.His textbook on diabetes mellitus in children and young adults is considered a classic.Dr. Danowski was a physician respected worldwide who dedicated his life to medicine, research, and patient care.He concentrated on academics but applied his knowledge to clinical work.He was also a creative teacher and administrator and did much to further the mission of ADA in the community and within our organization.
NEW DEVICES COMBINING DISSECTION AND SUCTION, FOR USE IN SEPTUM, TONSIL AND OTHER OPERATIONS
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Thyroid Hormone Receptor β (THRB) Is a Major Target Gene for Micro-RNAs Deregulated in Papillary Thyroid Carcinoma (PTC)
Authors: Krystian Jazdzewski, Joanna Boguslawska, Jaroslaw Jendrzejewski, Sandya Liyanarachchi, Janusz Pachucki, Kazimierz A. Wardyn, Alicja Nauman, Albert de la Chapelle
Journal: Endocrine Reviews (2011)

Loss of the thyroid hormone receptor is common in tumors. In mouse models, a truncated THRB gene leads to thyroid cancer. Previously, we observed up-regulation of the expression of eight micro-RNAs (miR) in papillary thyroid carcinoma (PTC) tumors. Our objective was to determine whether THRB might be inhibited by miR up-regulated in PTC. The potential binding of miR to the 3′-untranslated region of THRB was analyzed in silico. Direct inhibition by miR binding to the cloned 3′-untranslated region of THRB was evaluated using luciferase assays. Inhibition of endogenous THRB and its target genes (DIO1 and APP) was examined in cell lines transfected by pre-miR. The impact on thyroid hormone response elements (TRE) was evaluated in promoter assays. Correlations between the expression of THRB and miR was evaluated in 13 PTC tumor/normal tissue pairs. THRB contains binding sites for the top seven miR up-regulated in PTC (P = 0.0000002). Direct interaction with THRB was shown for miR-21 and miR-146a. We observed lower levels of THRB transcripts in cell lines transfected with miR-21, -146a, and -221 (down-regulation of 37–48%; P < 0.0001), but not with miR-181a. THRB protein was suppressed down to 10–28% by each of four miR. Concomitant expression of DIO1 and APP was affected (down-regulation of 32–66%, P < 0.0034 and up-regulation of 48–57%, P < 0.0002, respectively). All four miR affected TRE activity in promoter assays. Down-regulation of luciferase occurred after transfection with pTRE-TK-Luc construct and each of four miR. The analysis of tumor/normal tissue pairs revealed down-regulation of THRB in 11 of 13 pairs (1.3- to 9.1-fold), and up-regulation of miR-21, -146a, -181a, and -221 in almost all pairs. MiR up-regulated in PTC tumors directly inhibit the expression of THRB, an important tumor suppressor gene.
Remodelling of the cardiac extracellular matrix differs between volume and pressure overloaded ventricles and is specific for each heart valve lesion Cornelia Piper, Dieter Horstkotte, Daniel Akdemir, Joern Rudolf, Heinz-Peter Schultheiss, Matthias Pauschinger. Heart Center North Rhine-Westphalia, Bad Oeynhausen, Germany, University Hospital Benjamin Franklin, Berlin, Germany
Journal: Journal of the American College of Cardiology (2001)
Queries and Minor Notes
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Assessing Decisional Capacity for Clinical Research or Treatment: A Review of Instruments
Authors: Laura Dunn
Journal: American Journal of Psychiatry (2006)

Objective: The need to evaluate decisional capacity among patients in treatment settings as well as subjects in clinical research settings has increasingly gained attention. Decisional capacity is generally conceptualized to include not only an understanding of disclosed information but also an appreciation of its significance, the ability to use the information in reasoning, and the ability to express a clear choice. The authors critically reviewed existing measures of decisional capacity for research and treatment. Method: Electronic medical and legal databases were searched for articles published from 1980 to 2004 describing structured assessments of adults’ capacity to consent to clinical treatment or research protocols. The authors identified 23 decisional capacity assessment instruments and evaluated each in terms of format, content, administration features, and psychometric properties. Results: Six instruments focused solely on understanding of disclosed information, and 11 tested for understanding, appreciation, reasoning, and expression of a choice. The instruments varied substantially in format, degree of standardization of disclosures, flexibility of item content, and scoring procedures. Reliability and validity also varied widely. All instruments have limitations, ranging from lack of supporting psychometric data to lack of generalizability across contexts. Conclusions: Of the instruments reviewed, the MacArthur Competence Assessment Tools for Clinical Research and for Treatment have the most empirical support, although other instruments may be equally or better suited to certain situations. Contextual factors are important but understudied. Capacity assessment tools should undergo further empirically based development and refinement as well as testing with a variety of populations.
Manuscripts Approved for JNCI, April 1 to May 1, 1965
Journal: JNCI Journal of the National Cancer Institute (1965)

Manuscripts Approved for JNCI, April 1 to May 1, 1965 JNCI: Journal of the National Cancer Institute, Volume 34, Issue 6, June 1965, Pages 885–886, https://doi.org/10.1093/jnci/34.6.885-a Published: 01 June 1965