tbuckley/cabot-search huggingface dataset:
Anatomy, History
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Genetics of classical Hodgkin Lymphoma
Authors: Gianluca Schiavoni, Enrico Tiacci
Journal: HemaSphere (2018)

Institute of Hematology and Center for Hemato-Oncology Research, University and Hospital of Perugia, Italy This is an open access Abstract Book distributed under the Attribution-NonCommercial-NoDerivs (CCBY-NC-ND), which allows third parties to download the abstracts and share them with others as long as they credit the author and the abstract book, but they cannot change the content in any way or use them commercially. http://creativecommons.org/licenses/by-nc-nd/4.0
Maternity Beds Poorly Used Placentas and Radioisotopes Studied
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Guest Editorial
Authors: L.M. Shabad
Journal: JNCI Journal of the National Cancer Institute (1973)

Precancerous Morphologic LesionsTHE CONCEPT OF PRECANCER has not been studied sufficiently and some aspects remain disputable, especially in regard to the morphology and histologic definition of precancerous lesions.The concept of precancer and the term itself have been discussed many times and provoked fierce arguments.Clinicians accepted the idea of precancer, but included all the processes and diseases preceding cancer.Pathologists denied the concept of precancer and considered it impossible to prove the transition of a morphologic cancer precursor in to a malign an t tumor.They believed "cancerous" or "noncancerous" lesions could be identified only by microscopic study.Morphologic evaluation of the precancerous character of any lesion is difficult.If the pathologist finds such cancerous features in the tissue specimen as invasive and destructive growth, he decides that this is a cancer.If such features are absent, he cannot be sure that the lesions would lead to cancer because he is studying only a separate frame.Furthermore, the examined lesions cannot develop into cancer because they are already eliminated from the organism by biopsy or surgery.Another difficulty lies in the differentiation of many background, nonspecific processes from the true precancerous or pretumorous lesions.A Diffuse irregular hyperplasia PRENEOPLASIA 2 Nodular, focal proliferation Precancer
Brief Review
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Randomized clinical trials in single patients during a 2-year period
Authors: E. B. Larson
Journal: JAMA (1993)

<h3>Objective.</h3> —To describe the feasibility of a single patient trial (SPT) service and study the influence of formal SPTs on therapeutic precision. <h3>Design.</h3> —Descriptive and evaluative study of SPTs. All planned trials were double-blind, randomized, multiple crossover trials. Other key features of individual trials were random assignment of order and assessment of predetermined explicit outcomes. Patients and physicians rated level of confidence in treatment before and after the SPT on visual analog scales. <h3>Setting.</h3> —Two-year experience (September 1988 to September 1990) of an SPT trial referral service available to physicians in an academic medical center. <h3>Outcome Measures.</h3> —The number of planned and completed SPTs; proportion of completed trials yielding definitive answers; patient- and physician-rated levels of confidence in treatment pre- and post-SPT; time-motion studies to estimate resource consumption (costs) for selected SPTs. <h3>Results.</h3> —Of 34 completed trials, 17 were judged to give definitive results whereas 17 showed trends only. Results favored active treatment in 16 trials that led to treatment being continued (nine patients) or started (seven patients). Treatment was discontinued (seven patients) or not started (11 patients) based on 18 trial results that demonstrated active treatment was ineffective (seven), harmful (two), or apparently equivalent (nine). Most patients (65%) reported no change in their already high level of confidence in therapy as a result of trials, whereas physicians' confidence levels in therapy either increased or decreased post-SPT depending on the direction of trial results. Patients consistently rated the SPT service as extremely useful. Time-motion estimates indicate that 16.75 staff hours were spent per trial leading to a direct cost estimate of approximately $450 to $500 per trial. <h3>Conclusion.</h3> —We conclude that an SPT service is feasible, trial costs compare favorably with other conventional services, and clinicians appear to gain confidence and precision from SPTs. When patients or clinicians are uncertain about the value (including the possibility of side effects) of treatment for symptomatic chronic diseases, we believe an SPT can be offered to a patient and will likely yield results that will effect subsequent treatment. (<i>JAMA</i>. 1993;270:2708-2712)
The Schilling test
Authors: E. B. Silberstein
Journal: JAMA (1969)

The diagnosis of states of vitamin B<sub>12</sub>malabsorption, especially in patients with pernicious anemia, was enormously simplified by Schilling in 1953.<sup>1</sup>It had previously been noted by Conley et al<sup>2</sup>that raising the parenterally given dose of cyanocobalamin led to an increasing percent of that dose appearing in the urine. Subsequently, Schilling showed that a large injection (1 mg) of nonradioactive cyanocobalamin given two hours after oral administration of the radioisotope enhanced the percent of radioactive cyanocobalamin excreted. The mechanism involved appeared to be the blocking of vitamin B<sub>12</sub>-binding sites in liver and plasma by the parenterally given drug. Thus urine could replace stool<sup>3</sup>as biological material for measuring, albeit indirectly, vitamin B<sub>12</sub>absorption. Today, less commonly employed techniques include external hepatic scanning' and whole body counting.<sup>5</sup> The patient with pernicious anemia lacks the ability to produce intrinsic factor, a thermolabile glycoprotein
LOSS OF BONE SALTS DURING SCURVY
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Workshop summary and guidelines: Investigative use of bronchoscopy, lavage, and bronchial biopsies in asthma and other airway diseases
Authors: Suzanne Hurd, Robert Goldstein, Eugene Bleecker, E Regis Mcfadden, Homer Boushey, San Francisco, Eric Edell, Williaml Eschenbacher, Philippe Godard, Stephen Holgate, England Southampton, Gary Humunghake, Iowa City, Annika Laitinen, Lawrence Lichtenstein, Lawrence Prograis, John Rankin, West Haven, Ram Sri, Charles Reed, Her- Bert Reynolds, Robert Wood
Journal: Journal of Allergy and Clinical Immunology (1991)
THE VACCINATION ACTS
Authors: J. C. McVail
Journal: BMJ (1903)

Tms is the last question with which I propose to deal.For its complete consideration there would be necessary a knowledge of administrative detail which only the Local Government Board's staff can be expected to possess.Regarding the unsuitability of Boards of Guardians as vac- cination authorities there is a very general consensus of opinion.They are entirely Poor-law authorities, and the very idea of pauperism should be dissociated from the provision made for public vaccination.Also, guardians have no other public health functions, and vaccination is quite outside the natural field of their duties.At least three bodies have been suggested as best suited for administration of the Acts: the Local Government Board, the local sanitary authorities, and the county councils.In commenting on these suggestions it is to be understood that I am expressing merely my own individual opinion and not that of any society or committee of which I have the honour to be a member.THE LOCAL GOVERNMENT BOARD AND VACCINATION PROSECUTIONS.The Local Government Board does not seem to me to be at all a suitable,body for the bulk of the work.The whole ten- dency of administration in this country is in the direction of devoTution or localization, not of centralization.I cannot think either that Parliament would regard the Board as the body best fitted to carry out all the details of local adminis- tration of the Vaccination Acts, or that the Board itself would wish to undertake the du'ties.
The course of oesophagogastric varices in patients with cirrhosis after DAA-induced HCV clearance
Authors: V. Calvaruso, I. Cacciola, S. Petta, G. Caccamo, E. Conte, M. Licata, F. Simone, G. Squadrito, G. Raimondo, A. Craxi, V. DI Marco
Journal: Journal of Hepatology (2018)
BOOK REVIEWS
Authors: SCOTT M. LIPPMAN
Journal: JNCI Journal of the National Cancer Institute (1992)

Journal Article BOOK REVIEWS Get access Atlas of Diagnostic Oncology Arthur T. Skarin , ed. Philadelphia : J. B. Lippincott , 1991 . 450 pp., illus. $139.50 SCOTT M. LIPPMAN SCOTT M. LIPPMAN Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 84, Issue 15, 5 August 1992, Pages 1205–1206, https://doi.org/10.1093/jnci/84.15.1205 Published: 05 August 1992
Homemade Bomb Explosions Increase
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
OS08.2 A novel set of patient-derived orthotopic xenograft (PDOX) models of primary and recurrent intracranial meningioma
Authors: H. Zhang, L. Qi, Y. Du, F. Braun, M. Kogiso, S. Zhao, H. Lindsay, S. Injac, P. Baxter, J. Su, A. Patel, X. Li
Journal: Neuro-Oncology (2017)

Background: Meningioma is the most common brain tumors in adults. Despite the overall benign nature of meningioma, cranial-base tumors are difficult to achieve complete resection while others exhibit progression and aggressive profiles characterized by high recurrence rates, pleomorphic histology, and resistance to standard treatment. The lack of clinically relevant animal models is blocking the development of novel therapies. Here, we report our establishment of orthotopic xenograft mouse models and in vitro culture systems from surgical specimens of primary and recurrent meningiomas. Material and Methods: 6 primary surgical samples (3 WHO grade I and 3 atypical), and 4 recurrent samples (1 WHO grade I, 2 atypical and 1 anaplastic meningiomas) were obtained from meningioma patients. Tumor tissues were dissociated into single cells and directly implanted into right cranial base of NOD/SCID mice (1x105 cells/mouse). Primary cultures were initiated in serum-free and traditional FBS-based media. Tumor growth was monitored by small animal MRI. Pathologic features of the PDOX models and the matched patient tumors were compared with standard H&E and immunohistochemical staining. Molecular fidelity of PDOX tumor was examined through genomic analysis and comparison with the parental tumors. Results: Three of the 10 tumors were not tumorigenic, and xenograft tumor formation from 5 additional samples is pending. Growth of intracranial (cranial base) xenograft was confirmed in two samples derived from the same patient diagnosed as atypical meningioma (K029MEN) and progressed as anaplastic meningioma at recurrence (K037MEN). These patient derived orthotopic xenografts (PDOX) have since been serially subtransplanted in mouse brains for generation 2 and can be cryopreserved for long-term maintenance of tumorigenicity. The xenograft tumors replicated histopathological features (invasion, high proliferation and increased microvessel density) of their parental tumors. Genomic analysis is being performed to examine the similarities between parental tumors and the corresponding orthotopic xenograft tumors and the discrepancies between the primary and the recurrent tumor-derived models. In vitro growth of K029MEN and K037MEN as neurospheres and monolayer were maintained for 2 months and passage for 10 times. Additionally, cells from K030MEN, a WHO grade I meningioma, has been passaged as monolayer for more than 30 times. Conclusion: A novel set of meningioma PDOX models derived from matching primary and recurrent tumor was established. The xenograft tumors replicated the histopathological and key molecular features of the original patient tumors, providing a unique opportunity to understand the biology of malignant meningiomas and to conduct preclinical drug testing.
A Descriptive Atlas of Radiographs of the Bones and Joints. For Students and Practitioners.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Normal splanchnic but impaired peripheral insulin-stimulated glucose uptake in cirrhosis
Authors: E Shmueli
Journal: Hepatology (1993)

The site of impaired glucose uptake in cirrhosis is uncertain. We therefore performed hyperglycemic clamps (glucose 10 mmol/L) in 10 patients with compensated alcoholic cirrhosis and impaired glucose tolerance and in six control subjects. Muscle glucose uptake was estimated in patients and controls with the forearm technique. In the cirrhotic subjects splanchnic glucose uptake was measured with hepatic vein catheterization and primed continuous infusions of indocyanine green and [6−3H]glucose. To assess insulinindependent glucose uptake and the effects of elevated nonesterified fatty acid levels on glucose uptake, we repeated the study with somatostatin to induce insulin deficiency and a nicotinic acid analog, acipimox, to inhibit lipolysis. Substrate disposal was assessed on indirect calorimetry. Despite similar stimulated insulin levels, total glucose utilization was lower in the cirrhotic subjects (3.9 ± 0.3 vs. 8.8 ± 1.7 mg/kg/min, p = 0.006). This deficiency was accounted for by lower nonoxidative glucose disposal (1.2 ± 0.2 vs. 5.8 ± 1.6 mg/kg/min, p = 0.002). Forearm glucose uptake was lower in the cirrhotic subjects (0.39 ± 0.06 vs. 1.21 ± 0.3 mg/100 ml/min, p = 0.001). However, splanchnic glucose uptake at 1.59 ± 0.14 mg/kg/min was similar to that reported in other studies of normal subjects. Insulin-independent glucose uptake was normal, and acipimox had no effect on total or forearm glucose utilization. Glucose intolerance in cirrhosis is characterized by impaired peripheral insulin-stimulated nonoxidative glucose disposal. The high nonesterified fatty acid levels seen in cirrhosis most likely do not contribute to this defect. Splanchnic glucose uptake is normal in cirrhosis. (HEPATOLOGY 1993;18:86–95).
Binding of apolipoprotein A-I and acetaldehyde-modified apolipoprotein A-I to liver extracellular matrix
Authors: V Paradis
Journal: Hepatology (1996)

Apolipoprotein A-I (Apo A-I), a protein produced mainly by hepatocytes, is decreased in the sera of alcoholic patients with liver fibrosis and cirrhosis. To explain this decrease, we investigated possible interactions between liver extracellular matrix (ECM) and Apo A-I. Using a solid-phase binding assay, we evaluated the binding of Apo A-I to the different liver matrix components. Apo A-I bound significantly to fibronectin (FN) (optical density [OD] = 1.11 ± .26, P = .01) and collagen (C) I (OD = 0.91 ± 0.22, P = .02) in comparison with bovine serum albumin (BSA) (OD = 0.26 ± 0.16). Binding of Apo A-I to fibronectin was concentration dependent and saturable. Apo A-I bound also to ECM in vivo because Apo A-I was detected by immunofluorescence on fibrous septa in liver biopsy specimens of alcoholic patients. Because a negative correlation between Apo A-I and liver fibrosis is amplified in alcoholic patients, we investigated whether the in vitro formation of Apo A-I/acetaldehyde complex (adducts) increased the binding of Apo A-I to the ECM. We showed that the amount of Apo A-I that bound to FN was significantly higher with acetaldehyde-modified Apo A-I (OD = 2.18 ± 0.19, P = .01) than with native Apo A-I. This increase was probably related to the formation and binding of Apo A-I dimers, because immunoblot of in vitro acetaldehyde-modified Apo A-I showed the formation of dimeric Apo A-I. In conclusion, FN binds both native and acetaldehyde-modified Apo A-I. Because FN is deposited early and in excess during liver fibrosis, a storage mechanism of Apo A-I on newly deposited fibronectin would explain, in part, the decrease observed in alcoholic patients with liver fibrosis.
Epidermodysplasia verruciformis and epidermoid carcinoma. Electron microscopic observations
Authors: C. M. Aaronson
Journal: JAMA (1967)

The finding of papilloma virus in verruca plana-like lesions from a patient with epidermodysplasia verruciformis (EV) by means of electron microscopy has been confirmed in our patient. It has been suggested that EV is a genodermatosis characterized by reduced resistance to infection by the wart virus. Because of the frequent occurrence of skin cancer in patients with EV, it is possible that the common wart virus may be a carcinogenic agent in genetically predisposed patients.