tbuckley/cabot-search huggingface dataset:
Mastoid development in ancient and modern populations. A longitudinal radiological study
Authors: J. B. Gregg
Journal: JAMA (1982)

The effect of otitis media on the human mastoid process in a common milieu over a millennium was evaluated by comparing two present and four ancient populations. Temporal bone pneumatization patterns indicate that otitis media and mastoiditis existed in antiquity, and there were more altered pneumatization patterns in skulls from the era following European contact than from eras before European contact. Pneumatization patterns were similar in ancient skulls and in a preponderantly white male population mostly born before antibacterial availability. Both ancient and modern pre-antibacterial era temporal bones show more effect of otitis media during childhood than is found in present day schoolchildren. Reasons for differences are explored. It is inferred that upper respiratory tract infections were prevalent in the Upper Missouri River Basin during the past millennium. Furthermore, microbiological agents with virulence similar to today's flora were prevalent in this region more than 1,000 years ago. (<i>JAMA</i>1982;248:459-464)
NON-STEROIDAL ANTI-INFLAMMATORY DRUGS AND PERFORATED PEPTIC ULCER
Authors: D.St.J. Collier, J.A. Pain, SusanS. Jick, DavidR. Perera, AlexanderM. Walker, Hershel Jick, D.D. Kerrigan, A.J. Goodman, A.G. Johnson
Journal: The Lancet (1987)
Reimbursement problems encountered by private physicians. An example from a family practice in New York City
Authors: F. Siegel
Journal: JAMA (1981)

MY HUSBAND and I have shared a family medicine practice in the Bronx for many years. Five years ago I reduced my private practice and became the director of a family medicine residency program. As a result of my academic affiliation I began to consider some of the problems of the payment system used in the private practice of family medicine in New York City. Private family physicians receive the rewards of helping people, of problem solving, and of the positive feedback from patients, but they also have to earn a living, and I believe that there are inequities in the payment system. The payment systems we use are payment either by patients directly or by third-party payors: Workers' Compensation, Blue Shield (the largest supplier of medical insurance in the area), Medicare, and Medicaid. Although third-party payors have different reimbursement schedules for the various geographic localities of the country, I
Pulmonary Arteriosclerosis in Congenital Heart Disease
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 5138: Inhibition of kPNB1 and NUPR1 binding increase the anti-cancer drug sensitivity
Authors: Chan Hee Park, Seung Wook Ham, HyeKyoung Shin, Kyung Soo Oh
Journal: Cancer Research (2019)

Abstract Karyopherin beta 1 (KPNB1, known as importin beta 1) is carrier protein, it is known as transporter of protein from cytoplasm to nucleus through nuclear pore complexes (NPCs) using KPNAs as an adapters. The nuclear protein-1 (NUPR1, known as p8/Com-1) is identified as a transcription factor and it is showed multifunctional mechanisms related to cellular stress response such as serum-starvation, oxidative stress and drug stimulation. In this study, we investigated protein-protein interaction between NUPR1 and KPNB1, it might be a new target for cancer therapy.For the evaluation of binding affinity between protein and inhibition effect by compound 1, we processed the single molecule binding assay. Cytotoxicity of combination treatment with doxorubicin and compound 1 were validated several cancer cell lines such as MDA-MB-231, PC-3, SK-OV-3, and SiHa. Gene expression patterns were analyzed RNA-Seq and validated with qRT-PCR and western-blotting. KPNB1 bind to NUPR1 as a high affinity compare to KPNB1 single treatment assay and there was no difference according to concentration of NUPR1. KPNB1 and NUPR1 protein-protein interaction was inhibited by compound 1 according to concentration of compound 1 showed 71%, 44%, and 31% of inhibition rate with 50nM, 10nM, 2.5nM of compound 1, respectively. In doxorubicin single treatment, NUPR1 move to nucleus more than 90% of cells compare to non-treated MDA-MB-231 cells. Otherwise, NUPR1 was exist both nucleus and cytoplasm more than 90% cells, which is indicate that translocation of NUPR1 to the nucleus was blocked by compound 1 treatment. And combination treatment showed synergistic effect of cytotoxicity in various cancer cells such as such as MDA-MB-231, SiHa, PC-3, and SK-OV-3 (1.4 ~ 6 fold). Additionally, NUPR1 related genes were showed change of gene expression in compound 1 combination compared to doxorubicin single treatment. In these results suggest that translocation mechanism of NUPR1 into nucleus bind to KPNB1 and this binding was inhibited by compound 1 which is new candidate drug combination method for cancer therapy. Citation Format: Chan Hee Park, Seung Wook Ham, HyeKyoung Shin, Kyung Soo Oh. Inhibition of kPNB1 and NUPR1 binding increase the anti-cancer drug sensitivity [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 5138.
Immunohematologic diseases
Authors: B. Zweiman
Journal: JAMA (1982)

<h3>IMMUNE DISEASES INVOLVING RBCs</h3> NEARLY 400 different blood group antigens have been identified on the red cell membrane by their corresponding antibodies. As a result of this heterogeneity, the antigenic makeup of each individual's red cell is unique. Fortunately, most of these antigens are not highly immunogenic, otherwise blood transfusion would be impossible. For practical purposes, only the antigens of the ABO system and the D antigen in the Rh system are matched routinely. <h3>ABO Blood Group System</h3> Landsteiner published his discovery of the ABO blood group system in 1901; he had noted that serum from some of his laboratory employees would agglutinate red cells of other laboratory workers. Later, people were assigned to four categories that became known as the A, B, 0, and AB blood groups (Table 10-1). By about 6 months of age, normal persons form antibodies against the antigens of the ABO system that they lack.
Abstract 11043: Lipoprotein(a) Cholesterol but not Lipoprotein (a) Mass is Significantly Correlated With Angiographic Coronary Artery Disease and Major Adverse Events
Authors: Linnea Baudhuin, Sandra Bryant, Grant Spears, Stacy Hartman, Virend Somers, Peter Berger, Joseph McConnell, Allan Jaffe
Journal: Circulation (2015)

Introduction: Elevated plasma levels of lipoprotein(a) [Lp(a)] are associated with increased risk for coronary artery disease (CAD), but the strength of the association and whether it is independent of other risk factors remains controversial. Differences in prospective studies may be partially explained by variability in methods used to measure Lp(a). Methods: We utilized two different analytical methods (electrophoretic and immunologic) to measure Lp(a) and determine the predictive value of Llp(a) in assessing angiographic coronary artery disease (CAD) and association with major adverse events in 500 patients. Results: In univariate analyses, median Lp(a) cholesterol and Lp(a) mass were significantly associated with angiographic CAD. In a multivariable model, Lp(a) cholesterol remained a significant correlate of CAD (OR 1.61, 95% CI 1.13-2.31, P = 0.009) while Lp(a) mass was not (OR 1.18, 95% CI 0.95-1.47, P = 0.14). Additionally, on multivariable analysis, the presence of a detectable amount of Lp(a) cholesterol (&gt; or =2.5 mg/dL) was more strongly correlated with CAD than HDL cholesterol &lt; 40 mg/dL, and, along withLp(a) cholesterol, was strongly correlated with major adverse events (OR 2.08 95% CI 1.22-3.56, P = 0.007 and OR 1.22, 95% CI 1.05-1.42, P = 0.012, respectively). Conclusions: Lp(a) cholesterol measured electrophoretically is independently correlated with angiographic CAD and presence of major adverse events, and may be used as an alternative or supplement to Lp(a) mass analysis.
American Journal of Ophthalmology, Chicago
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE PASSING OF DOWIE.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PWE-010 Dietary campesterol is inversely associated with the risk of developing oesophageal adenocarcinoma: a UK prospective study in the EPIC-Norfolk cohort, using information from 7-day food diaries
Authors: L Alexandre, M Yates, R Luben, E Cheong, L Igali, R Fitzgerald, K-T Khaw, A Hart
Journal: Gut (2012)

<h3>Introduction</h3> Dietary phytosterols (PS), including campesterol, the most bioavailable of this group, are structurally similar to cholesterol, and are present in grain legumes, cereals, nuts and vegetable oils. Experimental studies have shown PS have several anticarcinogenic effects, including inducing apoptosis and inhibiting both angiogenesis and cell proliferation. The aim of this study was to conduct the first epidemiological investigation to determine if an inverse association exists between PS intake and the risk of both Barrett9s oesophagus (BO) and oesophageal adenocarcinoma (OAC). <h3>Methods</h3> A total of 25 639 men and women aged 40–75 years, were recruited between the years 1993 and 1997 into the European Prospective Investigation into Cancer (EPIC)-Norfolk cohort Study. At baseline, participants completed detailed 7-day food diaries which were coded by nutritionists. Subjects were followed-up over subsequent years for the development of BO and OAC. A review of case notes confirmed these diagnoses. Dietary intakes were compared between cases and a random sample of 3 797 controls in a case-cohort analysis. Cox regression estimated the HR for both campesterol and total PS. <h3>Results</h3> During follow-up, 104 patients were diagnosed with BO (80% men, median age 67.0 yrs [IQR 61.1–73.1] at diagnosis) after a median follow-up of 6.2 yrs (IQR 4.1–8.1). A further 63 patients developed OAC (83% men, median age 73.0 yrs [IQR 67.0–78.0] at diagnosis) after a median follow-up of 6.4 yrs (IQR 4.4–8.9). For BO, no significant associations were found with campesterol (HR 1.47, 95% CI 0.77 to 2.79) or total dietary PS (HR 1.28, 95% CI 0.70 to 2.33), in either sex. For OAC, in men, there were inverse associations with campesterol (HR 0.43, 95% CI 0.22 to 0.83, p=0.01), in a threshold manner, comparing the lowest with a summation of the top four quintiles of intake. In women, for OAC, there were no such associations with campesterol (HR 2.13, 95% CI 0.44 to 10.15, p=0.34). Total PS intake (HR 0.71, 95% CI 0.38 to 1.35) was not significantly associated with OAC in either sex. <h3>Conclusion</h3> Campesterol intake was associated with an approximate 55% risk reduction for OAC in men, although there were no significant effects in BO or for either condition in women. The data support a role for dietary campesterol, in preventing the malignant transformation of BO to OAC, and therefore these micronutrients should be measured in future aetiological studies of OAC. <h3>Competing interests</h3> None declared.
Roentgenographic manifestations of ischemic colitis
Authors: R. M. Gore
Journal: JAMA (1979)

A FREQUENTLY encountered diagnostic problem in older persons is acute abdominal pain accompanied by bloody diarrhea, invoking the differential diagnosis of diverticulitis, inflammatory bowel disease, infectious colitis, carcinoma of the colon, and ischemic colitis.<sup>1,2</sup>The roentgenographic manifestations of ischemic colitis, namely, "thumbprinting," bowel-wall edema, ulcerations, intramural dissection of barium, and stricture, often resemble those of these other disease processes, and recognition may be difficult.<sup>3,4</sup> Acute vascular insufficiency of the colon is a disease complex that presents as a spectrum ranging in severity from gangrenous infarction causing peritonitis and shock to a trivial episode of abdominal pain and diarrhea that a patient may recall only in retrospect.<sup>5,6</sup>Where in this continuum an individual patient may fall depends on the duration and extent of the ischemia, the efficiency of collateral circulation, and the extent of bacterial invasion.<sup>7,8</sup> <h3>Gangrenous Colitis</h3> The catastrophic expression of colonic ischemia, gangrenous colitis, is
THE BEDSIDE DETERMINATION OF THE BLOOD UREA NITROGEN
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
NCCN NewsNCCN Statement on FDA Leadership and Vision for the FutureNCCN and Pfizer Address Quality Improvement in Breast Cancer Through Clinical PathwaysNCCN Survey Reveals Oncology's Concerns About Financial Distress, Patient Access to CareNine New Disease Sites Added to the NCCN Radiation Therapy CompendiumIn Oncology Nursing, One Small Change Can Potentially Prevent Deadly Medical Error in Thousands of Patients
Journal: Journal of the National Comprehensive Cancer Network (2017)

Improvement in Breast Cancer Through Clinical PathwaysEvidence-and systems-based standardization of clinical processes, such as the NCCN Guidelines, support decision-making and quality improvement (QI) in the care of patients with cancer.Moreover, clinical pathways have emerged as point-of-care informational tools used by healthcare providers to improve quality of care based on the most current medical evidence and recommendations within the NCCN Guidelines.Cont. on page xxxiv.
Diagnostik und Therapie der Kinderkrankheiten mit speziellen Arzneiverordnungen für das Kindesalter. Ein Wegweiser für den praktischen Arzt.
Journal: JAMA (1929)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Marriages
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The duty to "attend upon the sick'
Authors: O. W. Clarke
Journal: JAMA (1991)

The American Medical Association's (AMA) Council on Ethical and Judicial Affairs has stated, "[A] physician may not ethically refuse to treat a patient whose condition is within the physician's current realm of competence solely because the patient is seropositive [for human immunodeficiency virus (HIV)]."<sup>2</sup>This position articulates the medical profession's long-established tradition of treating those in need without regard to the risks that treatment may present to the physician. The statement is also grounded in the fact that while the AMA'S Principles of Medical Ethics recognize that physicians have freedom to choose whom to serve, the Council on Ethical and Judicial Affairs has never interpreted this principle to endorse "illegal or invidious discrimination. "<sup>2</sup>Any discrimination that emanates from members of the medical profession is particularly objectionable because of medicine's professed commitment to moral ideals. Indeed, that physicians regard themselves as professionals testifies to their pursuit of ethical objectives.
Rectal Alimentation
Authors: W. J. Tyson
Journal: BMJ (1882)

IT seems somewhat strange, considering the frequency of those cases in which no food can he retained by the stomach, that more attention has not been paid to the introduction of aliment by the rectum.To show how little this method of feeding is valued, I quote the following paragraph from WVood's well-known treatise on 7herapeutics (second edition): "The solvent influence of the rectal juices is practically nothing, and formerlythe attempt was made to supplement this complete lack of power by the use of soups.It is evident that very little nutriment can be introduced into the system by such a plan; and, consequently, feeding by the rectum has hitherto been a forlorn hope, and has accom- plished little good."Here, I take it, the author is speaking of
Even as new options emerge, gynecologists urge women to find older contraceptives user-friendly
Authors: K. Titus
Journal: JAMA (1996)

EVEN AS researchers continue to develop new forms of birth control—including Norplant II, injectable contraceptives, vaginal rings, contraceptive patches, and male contraceptives—older, effective methods are often misunderstood by both physicians and their patients. And while the adverse effects of current contraceptives are widely known, the benefits are too often overlooked, noted a panel of physicians at the annual clinical meeting of the American College of Obstetricians and Gynecologists (ACOG) in Denver, Colo. The result: Women avoid some methods unnecessarily and use others ineffectively. "We can't afford to underestimate the effectiveness of birth control and overestimate its risks," said Luella Klein, MD, director of ACOG's Department of Women's Health Issues. Although women who take oral contraceptives experience more regular menstrual cycles, less cramping, fewer breast and ovarian cysts, and less cancer in the lining of the uterus, for example, physicians rarely point out those benefits to patients, Klein observed. "On our