tbuckley/cabot-search huggingface dataset:
Use of Growth Hormone for Non—Growth Hormone Deficient Children
Authors: David A. Voron
Journal: JAMA (1996)

<h3>To the Editor.</h3> —In an otherwise carefully written Editorial,<sup>1</sup>Bercu, referring to a paper by Wit et al,<sup>2</sup>states "growth outcome correlated best with low GH response to provocative testing, low GH secretion, and delayed bone age." Actually, according to the reference cited, "little bone age delay predicted a favorable outcome." In other words, the less the bone age delay, the more favorable the outcome.
Council on Medical Education and Hospitals
Journal: JAMA (1949)

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New Instrument.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Course of Lectures on Venereal Affections Delivered at the Hopital Du Midi, Paris
Authors: P. Ricord
Journal: BMJ (1843)

Classification of venereal diseases-Arguments for the identity of syphilis and gonorrhoea-Opinions of authors-Test of inoculation-Question of incubation-Opinion of the author-Gonorrhesa virulenta -Bubo-Consequences of gonorrhoea-Compara- tivefrequency of gonorrhoea and chancre.GENTLEMEN,-In the foregoing lectures I have di- vided venereal affections into two orders-the first, non-virulent; the second, virulent; and it now be-
Current Comment
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Corrigendum
Journal: BMJ (1933)

~~~~~~~~~~~~~~~~~~~~M DIALJOURNAL' that hie may easily follow instructions in books for manipulations or movements, that he may learn almost anything from any teacher-music, handicraft, etc .-withoutthat teacher at some time losing his patience.A problem which someonie no doubt can elucidate, but whiclh hias for years puzzled me, is this: If I ceased to learn to write back-side foremost with my left hand wheni I was about 7, and have hardly practised the art since then, why, to-day, is my mirror-writing not much worse than my ordinary handwriting?
Encore
Authors: None Gemaennes
Journal: Annals of the Rheumatic Diseases (1989)

Polymyalgia rheumatica and hypothyroidismThere is a possible association between polymyalgia rheumatica, giant cell arteritis, and hypothyroidism either concurrently, or with the hypothyroidism occurring later, and this study in the British Medical Journal suggests a common autoimmune cause.It remains to be worked out and indeed confirmed, however.
Prevention And Treatment Of Pneumocystis Carinii Pneumonia
Authors: W. Hughes
Journal: Annual Review of Medicine (1991)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease 2019 (COVID-19), emerged in China in December 2019 and quickly spread around the globe, killing more than 4 million people and causing a severe economic crisis. ...Read More
Omitted Digit
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Relation of<i>H pylori</i> to gastric mucins and gastric surface mucous gel layer
Authors: H OTA, J NAKAYAMA, T SHIMIZU, J NAKAYAMA, D Y GRAHAM, T KATSUYAMA
Journal: Gut (2001)

Editor,—We read with considerable interest the excellent article on Helicobacter pylori colonisation with MUC5AC in the human stomach by Van den Brink et al ((2000) Gut 46:601–7; [OpenUrl][1][Abstract/FREE Full Text][2]). The authors used antibodies against gastric mucin core proteins (anti-MUC6 and MUC5AC (45M1)) in conjunction with antibody against H pylori and demonstrated attachment of H pylori to gastric surface mucous cells and the presence of H pylori in extracellular mucins derived from gastric surface mucous cells. These finding are similar to those previously reported by us1 using histochemical staining specific for gastric mucins (dual staining consisting of galactose-oxidase cold thionine Schiff reaction (GOTS) and paradoxical concanavalin A staining (PCS))2, and immunostaining for H pylori. GOTS recognises galactose or N -acetyl galactosamine residues of gastric surface mucous cell mucins and stains gastric surface mucous cell mucins blue (fig 1A). Histochemical reactivity of GOTS is identical to that of immunostaining with anti-MUC5AC (45M1) (fig 1B). PCS recognises the specific sugar residues with peripheral N -acetyl glucosamine in gastric gland mucous cells (cardiac gland cells, mucous neck cells, and pyloric gland cells) and stains gastric gland mucous cell mucins brown (fig 1A). We used tissue sections from surgically resected stomachs fixed in Carnoy's solution which has the advantage of fixing the gastric surface mucous gel layer (SMGL) in paraffin embedded tissue sections.3 Figure 1 (A, B) Formalin fixed normal fundic mucosa. (A) Galactose-oxidase cold thionine Schiff reaction (GOTS) stains gastric surface mucous cell mucins blue and paradoxical concanavalin A staining (PCS) stains mucous neck cell mucins brown (dual staining of GOTS-PCS). (B) Immunostaining with anti-MUC5AC (45M1) labels gastric surface mucous cells. … [1]: {openurl}?query=rft.jtitle%253DGut%26rft.stitle%253DGut%26rft.aulast%253DZheng%26rft.auinit1%253DP%2BY%26rft.volume%253D47%26rft.issue%253D1%26rft.spage%253D18%26rft.epage%253D22%26rft.atitle%253DAssociation%2Bof%2Bpeptic%2Bulcer%2Bwith%2Bincreased%2Bexpression%2Bof%2BLewis%2Bantigens%2Bbut%2Bnot%2BcagA%252C%2BiceA%252C%2Band%2BvacA%2Bin%2BHelicobacter%2Bpylori%2Bisolates%2Bin%2Ban%2BAsian%2Bpopulation%26rft_id%253Dinfo%253Adoi%252F10.1136%252Fgut.47.1.18%26rft_id%253Dinfo%253Apmid%252F10861258%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/ijlink?linkType=ABST&journalCode=gutjnl&resid=47/1/18&atom=%2Fgutjnl%2F48%2F6%2F869.2.atom
AMA Insights
Journal: JAMA (1982)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Outcome of Very Young (≤ 40 years) Patients with Immunoglobulin Light Chain Amyloidosis (AL): A Case Control Study
Authors: Jithma P Abeykoon, Miriam Hobbs, Jonas Paludo, Dirk R Larson, Angela Dispenzieri, Morie A. Gertz, Francis K. Baudi, S. Vincent Rajkumar, David Dingli, Wilson I Gonsalves, Nelson Leung, Robert A. Kyle, Martha Q. Lacy, Suzanne R. Hayman, Taxiarchis Kourelis, Yi Lin, Shaji Kumar, Prashant Kapoor
Journal: Blood (2016)
An approach to detecting delayed effects of radioactive contamination on industrial-urban-area dwellers.
Authors: L I Privalova, B A Katsnelson, E V Polzik, V S Kazantsev, None Lipatov GYa, Y B Beikin
Journal: Environmental Health Perspectives (1994)

Detecting changes in humans that result from radioactive contamination of the area of residence many years after an incident (i.e., when the radiation has substantially decayed) presents a difficult epidemiological problem. Problems of this kind are even more complicated ina areas where the population is continually exposed to other harmful man-made factors. The city of Kamensk-Uralsky (Sverdlovsk region, Russia) is a good case in point. In 1957, part of Kamensk-Uralsky was contaminated as the result of an accident at the Kyshtym nuclear plant. In addition, the population of the contaminated area is being exposed to atmospheric emissions from several industrial enterprises. Two comparable groups of residents were formed: one in the contaminated are and another in a control area within the same city characterized by similar levels of chemical pollution but substantially lower radioactive contamination. The groups were composed of only those people who had been living in these areas continually since time of the accident and who were under 15 years of age at the time of the accident. The groups were matched by sex, age, and socio-occupational characteristics. For each subject, data were gathered on more than 50 parameters including hematological, immunological, and biochemical indices of the health status. All these data were obtained from blood tests taken in the fall of 1992. Data processing was carried out with the help of a computerized mathematical pattern recognition methodology, which ensured reliable discrimination between the generalized health status in the areas under study. We found that the health status of inhabitants of the area more contaminated with radioactive fallouts was adversely affected by radiation.
Genetic Studies of Genius.
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Arthritis and Rheumatism, New York
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Benign Atrial Fibrillation of Forty Years Duration with Sudden Death from Emotion
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Role of Cadmium in Carcinogenesis with Special Reference to Cancer of the Prostate
Authors: Magnus Piscator
Journal: Environmental Health Perspectives (1981)

It has been shown in animal experiments that injections of large amounts of cadmium cause sarcoma at injection sites or testicular damage and eventually testicular tumors. Long-term exposure with small doses of cadmium has not caused testicular or prostatic tumors in experimental animals. Epidemiological studies on cadmium-exposed workers have shown excess deaths due to prostatic cancer in at least three independent investigations. All reported cases probably had considerable exposure decades ago, but there are not enough data to permit any dose-response calculations. The general epidemiology of prostatic cancer was not taken into account in any of the studies. A review of recent literature on epidemiology of prostatic cancer has revealed some basic facts. Small latent prostatic cancer has been shown to be as common in areas with low mortality from prostatic cancer as in areas with high mortality. In the U.S. the black population has a much higher death rate from prostatic cancer than the white population. Marital status has also been implied as a factor in the development of prostatic cancer. Black populations in Africa have much lower death rates than blacks in the U.S., which may depend on large differences in dietary habits. Thus racial, sexual and nutritional factors might be important for the development of prostatic cancer, since they may influence hormonal status. Cadmium concentrations in testes and prostate increase during heavy exposure, and it has been shown that testosterone synthesis will decrease in cadmium-exposed animals. Excessive exposure may interfere with the zinc/hormone relationship in the prostate, which could be a possible explanation for the development of prostatic cancer in heavily exposed individuals. Direct action of cadmium on the cells is not likely, nor is it probable that low level exposure to cadmium can be a causative factor for prostatic cancer.
A randomized double-blind 2x2 trial of low-dose tamoxifen and fenretinide for breast cancer prevention of high-risk premenopausal women
Authors: A. Decensi, C. Robertson, A. Guerrieri-Gonzaga, D. Serrano, M. Cazzaniga, M. Gulisano, H. Johansson, E. Cassano, S. Moroni, K. Johnson, B. Bonanni
Journal: Journal of Clinical Oncology (2008)

1503 Background: Tamoxifen (T) and fenretinide (F) are active in preventing premenopausal breast cancer and work synergistically in preclinical models. We assessed the activity of their combination in a 2x2 biomarker trial. Methods: We randomly assigned 235 premenopausal women with intraepithelial neoplasia (IEN) or Gail risk>1.3% to either T, 5 mg/day, or F, 200 mg/day, or T+F, or placebo for 2 years. Here we report data after a median of 5.5 years on plasma IGF-I, IGF-I/IGFBP-3, mammographic %density, endometrial thickness and breast cancer events. Results: T induced a 20% reduction of IGF-I and IGF-I/BP-3 in the IEN strata (n=181) versus a 9% reduction in the Gail strata (n=54), whereas F only slightly lowered IGFs levels. T lowered mammographic density by 21% (95% CI, 16–26%) at 24 months, compared with 11% (3–20%) on placebo (p=0.026), whereas F did not affect mammographic density. T increased endometrial thickness and uterine volume in women becoming postmenopausal during the trial, whereas F significantly reduced endometrial thickness and uterine volume. As of Nov 2007, 51 women developed breast cancer, mostly in the IEN strata, with an annual %rate (±SD) of 3.5±1.1, 2.7±0.9, 5.1±1.3 and 5.2±1.3 on T, F, T+F and placebo, respectively. Cox analysis in table shows some evidence of an antagonistic interaction between T and F (p=0.046 vs placebo). Adjusting for baseline ER, PgR or HER-2 status of the IEN strata had no influence on the interaction estimate. Plasma IGF-I had a strong predictive trend on breast neoplasms (p=0.008). Conclusions: Low-dose T and F given alone show promising activity in premenopausal breast cancer prevention, but their combination may be adverse. T lowers IGF-I more profoundly in women with prior IEN than in unaffected women and decreases mammographic density like the standard dose, whereas F has antiestrogenic effects at uterine level. Our clinical data support the role of circulating IGF-I as a risk biomarker for premenopausal breast cancer. Multivariate Cox regression analysis of breast cancer incidence Variable HR 95% CI p Disease status at baseline (Gail vs IEN) 5.94 1.43-24.64 0.014 T 0.65 0.29-1.44 0.280 F 0.48 0.21-1.09 0.081 T+F 3.23 1.02-10.20 0.046 IGF-I quartile 0.008 lowest 1.00 - middle low 0.98 0.42-2.29 middle high 1.11 0.48-2.58 top 1.50 0.67-3.34 No significant financial relationships to disclose.