tbuckley/cabot-search huggingface dataset:
Comparative Ga-67 Citrate and Bone Scintigraphy in Disseminated Blastomycosis
Authors: WEI-JEN SHIH, PRIMO P. MILAN
Journal: Clinical Nuclear Medicine (2003)

Blastomycosis is a systemic illness, and the disease eventually spreads to multiple organs or develops multifocal involvement. Cutaneous and skeletal involvement are the two most common extrapulmonary manifestations. Because serologic and skin tests are not reliable, diagnosis of the disease is made only by visualization of the organism in tissue, sputum, exudates, or by culture. Ga-67 citrate and whole-body bone imaging may play important roles in diagnosis. The authors describe a patient with disseminated blastomycosis proved by skin biopsy who underwent bone and Ga-67 citrate wholebody imaging. Both bone and Ga-67 citrate studies showed a large area of increased uptake in the entire upper third of the proximal right tibia, and focal lesions in the left femur and in the skin of the chin. Ga-67 citrate imaging did not reveal the T-10 vertebra and two rib lesions, a pulmonary lesion, or other skin lesions. The patient received amphotericin B and traconazole therapy. The right tibia lesion resolved, as evidenced by a radiologic examination performed 5 months later. References
Electromagnetic fields and circadian rhythms
Authors: P. J. Schwartz
Journal: JAMA (1993)

<h3>In Reply.</h3> —I appreciate Dr Schwartz's comments and would agree that the effects of power frequency EMFs on human behavior are important to study. However, I would disagree that the effects of EMF on human circadian rhythms are "well-documented." There is only one existing report of such an effect, that cited by Dr Schwartz, ie, the work of Wever conducted on humans and finches in an underground bunker, first published in 1973 and recently reviewed by Wever.<sup>1</sup>The human work has never been replicated, either by Wever or by anyone else. A recent attempt to replicate the observations on finches, conducted in the same German bunker under conditions identical to those used by Wever, failed to show effects.<sup>2</sup> While there is work suggesting that EMFs do affect circadian rhythms in rodents,<sup>3</sup>one must be cautious in extrapolating these results to humans. For one thing, the exposures used
Hematologic effects of intrauterine rubella
Authors: A. R. Rausen
Journal: JAMA (1967)

Six of 21 newborn infants with congenital rubella studied in 1964 and 1965 had hematologic abnormalities. These six infants had transient thrombocytopenic purpura with sparse numbers of megakaryocytes in the bone marrow. In addition, they had indications of partially compensated hemolytic disease. These included abnormalities of red blood cell morphology, transient anemia at the end of the first month of life, and normoblastemia, reticulocytosis, and erythroid hyperplasia of the bone marrow in the immediate neonatal period. Other stigmata of intrauterine rubella in these six infants included congenital heart disease, cataracts, intrauterine growth retardation, hepatosplenomegaly, histologic evidence of hepatitis, metaphysitis of the long bones, hypospadias, and cryptorchidism.
Social Darwinism
Authors: Michael A. LaCombe
Journal: JAMA (1988)

... Look, you came to me and you've got a complaint and I'll handle it, OK? But you let me be the lawyer and do this my way or you can look for somebody else. OK, OK, I just don't like somebody telling me my business, that's all. Look, we both know he's responsible for this. But you've got to sue everybody in a case like this. That's just the way it's done. That's the way the court system runs. You sue everybody to make it a big deal and very complicated and that increases your chances of winning the suit. No, it's not a question of hurting the other doctors at all. That never enters their minds, believe me. They know this is just the cost of doing business. They've got coverage, understand? It's their insurance that gets burned. Trust me. ... I don't understand why he left town, Emily. He
Preserved arterial wall thickening after injury in IGF-1m/m mice Hongyan Li, Mojca Remskar, Juliana Yano, Mario Fournier, Kuang-Yuh Chyu, Prediman K. Shah, Bojan Cercek. Atherosclerosis Research Center, Cedars-Sinai Medical Center, Los Angeles, CA
Journal: Journal of the American College of Cardiology (2001)
Editorial: Rifampicin or ethambutol in the routine treatment of tuberculosis.
Journal: BMJ (1973)

R:ifampici or Ethambutol in the Routine Treatment of Tuberculosis Rifampicin and ethambutol have now been used for some years in the retreatment of tuberculous patients with tubercle bacilli resistant to the standard drugs.Their proved efficacy, their excellent toleration by patients, and their relative lack of toxicity have raised the question whether they might be given in primary treatment of newly diagnosed cases, especially as a substitute for para-amino salicylic acid (PAS), the most troublesome ofthe three classical drugs.A trial by the Medical Research Council was designed to answer this question.A secondary objective was to compare as follow-up treatment streptomycin plus high-dosage isoniazid, given under super- vision twice weekly, with the classical PAS plus isoniazid, and with ethambutol or rifampicin plus isoniazid.The trial was co-operative and carried out in 51 centres in Britain.A report on it has recently been published.'
Effect of Corticosteroid Treatment on Various Clinical Forms of Primary Tuberculosis in Children
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction: Increased risk of ischemic heart disease, hypertension, and type 2 diabetes in women with previous gestational diabetes mellitus, a target group in general practice for preventive interventions: A population-based cohort study
Authors: Barbara Daly, Konstantinos A. Toulis, Neil Thomas, Krishna Gokhale, James Martin, Jonathan Webber, Deepi Keerthy, Kate Jolly, Ponnusamy Saravanan, Krishnarajah Nirantharakumar
Journal: PLoS Medicine (2019)

[This corrects the article DOI: 10.1371/journal.pmed.1002488.].
Nursing home residents' preferences for life-sustaining treatments
Authors: L. A. O'Brien
Journal: JAMA (1995)

<h3>Objectives.</h3> —To determine life-sustaining treatment preferences among nursing home residents, whether information regarding cardiopulmonary resuscitation (CPR) affected these preferences, and with whom treatment preferences had been discussed, and to identify factors associated with CPR preferences. <h3>Design.</h3> —In-person survey. <h3>Setting.</h3> —Forty-nine randomly selected nursing homes. <h3>Subjects.</h3> —Four hundred twenty-one randomly selected nursing home residents capable of making decisions. <h3>Main Outcome Measures.</h3> —Preferences regarding CPR, hospitalization, and enteral tube feedings, and individual factors associated with CPR preferences. <h3>Results.</h3> —Of 1458 randomly selected nursing home residents assessed for the ability to participate in the study, 552 residents (38%) were eligible to participate and 421 agreed to be interviewed. Sixty percent of participants able to participate in the decision reported that they would elect CPR, 89% would choose hospitalization if seriously ill, and 33% would elect enteral tube feedings if no longer able to eat because of permanent brain damage. Individual factors associated with preferences for CPR included the following: African-American ethnicity, high self-reported physical mobility, belief that most important medical care decisions should be made by the doctor, moderate-to-severe impairment in daily decision-making skills, and not having a spouse. Fourteen percent changed their preference from preferring CPR to not preferring CPR after receiving additional information about CPR procedures. Twelve percent reported having discussed preferences with health care providers, and 31% discussed preferences with family members. <h3>Conclusions.</h3> —More than half of nursing home residents capable of making decisions preferred the use of CPR. Few had discussed their preferences with health care providers. Individual preferences should be assessed when considering the use of life-sustaining treatments. (<i>JAMA</i>. 1995;274:1775-1779)
Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity
Authors: David K. Cole, Anna M. Bulek, Garry Dolton, Andrea J. Schauenberg, Barbara Szomolay, William Rittase, Andrew Trimby, Prithiviraj Jothikumar, Anna Fuller, Ania Skowera, Jamie Rossjohn, Cheng Zhu, John J. Miles, Mark Peakman, Linda Wooldridge, Pierre J. Rizkallah, Andrew K. Sewell
Journal: Journal of Clinical Investigation (2016)
THE EARLY PUBLICATION OF THE RESULTS OF ORIGINAL RESEARCH.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Screening examinations. Relationship to environmental contamination
Authors: L. E. Farr
Journal: JAMA (1967)

Screening examinations as presently structured do not detect incipient disease related to environmental factors. As exemplified for environmental radioactivity, sound, and air pollution, screening examinations today cannot be related to the environmental parameters presently reported. Data on individuals from properly structured longitudinal screening examinations, if properly related to environmental criteria, may be important in validating the maximum permissible limits for contamination. Such examinations will permit establishment of mean values for a variety of attributes and of the expected variations in the means for those individuals. With such data, probabilities of detection of incipient diseases related to the environment are greatly enhanced. Longitudinal screening examinations properly structured can yield valuable information about the efficacy of social controls upon activities resulting in environmental contamination.
“Efficacy and safety of budesonide/formoterol in the management of chronic obstructive pulmonary disease”. W. Szafranski, A. Cukier, A. Ramirez, G. Menga, R. Sansores, S. Nahabedian, S. Peterson, H. Olsson.<i>Eur Respir J</i>2003; 21: 74–81.: 1
Journal: European Respiratory Journal (2003)
G. Armauer Hansen
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An Exploratory Analysis of the Effect of Pesticide Exposure on the Risk of Spontaneous Abortion in an Ontario Farm Population
Authors: Tye E. Arbuckle, Zhiqiu Lin, Leslie S. Mery
Journal: Environmental Health Perspectives (2001)

The toxicity of pesticides on human reproduction is largely unknown--particularly how mixtures of pesticide products might affect fetal toxicity. The Ontario Farm Family Health Study collected data by questionnaire on the identity and timing of pesticide use on the farm, lifestyle factors, and a complete reproductive history from the farm operator and eligible couples living on the farm. A total of 2,110 women provided information on 3,936 pregnancies, including 395 spontaneous abortions. To explore critical windows of exposure and target sites for toxicity, we examined exposures separately for preconception (3 months before and up to month of conception) and postconception (first trimester) windows and for early (< 12 weeks) and late (12-19 weeks) spontaneous abortions. We observed moderate increases in risk of early abortions for preconception exposures to phenoxy acetic acid herbicides [odds ratio (OR) = 1.5; 95% confidence interval (CI), 1.1-2.1], triazines (OR = 1.4; 95% CI, 1.0-2.0), and any herbicide (OR = 1.4; 95% CI, 1.1-1.9). For late abortions, preconception exposure to glyphosate (OR = 1.7; 95% CI, 1.0-2.9), thiocarbamates (OR = 1.8; 95% CI, 1.1-3.0), and the miscellaneous class of pesticides (OR = 1.5; 95% CI, 1.0-2.4) was associated with elevated risks. Postconception exposures were generally associated with late spontaneous abortions. Older maternal age (> 34 years of age) was the strongest risk factor for spontaneous abortions, and we observed several interactions between pesticides in the older age group using Classification and Regression Tree analysis. This study shows that timing of exposure and restricting analyses to more homogeneous endpoints are important in characterizing the reproductive toxicity of pesticides.
Wilms' Tumor
Authors: Mark A. Immergut
Journal: JAMA (1971)

<h3>To the Editor.—</h3> A 21/2-year survival of a patient with a ruptured Wilms' tumor was reported by Pochedly et al (<b>216</b>:334, 1971). Although the case report was quite interesting and an excellent result was eventually achieved with the combination of surgery, chemotherapy, and radiation therapy, I think it should be pointed out that the nephrectomy was performed on a patient with no evaluation of the contralateral kidney. The 5-year-old child was admitted to the Nassau County Medical Center emergency room and taken to the operating room after sustaining abdominal trauma. A right nephrectomy was performed. Since no preoperative intravenous pyelogram had been performed, the authors knew only that an organ which palpably appeared to be similar to a kidney existed in the left renal fossa. Moreover, they had no inkling as to the function of a left kidney if it were present. Removal of one kidney in the
The Proteins of Human Bile
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Gulstonian Lectures, on the Sterility of Women
Authors: J. M. Duncan
Journal: BMJ (1883)

AND GENTLEMEN,-In studying the theory or inquiring into t-he causes of sterility in women, it is advantageous to keep in mind the corresponding condition in plants and in the lower animals, for in all living beings there is more or less similarity of the sexual organs and offices, and disturbance o function in one division will throw light on disturbance in another On this subject I have made many, but only casual, observations and have had the privilege of conversation with gardeners -and breeders, classes of men in whom are found many of remarkable intelligence and acuteness of observation.But the great storehouse of facts and references on which I rely is Darwin's Variation of Animals and Plants under Donestication.Plants, and some animals, propagate otherwise than by sexual generation, but it is only the sterility arisig from disturbance of the regular course and consequences of sexual.unionthat has a direct ;or nearly direct bearing on the present inquiry.The sterility of h'ybrids, which, considering the theory he is supporting, forms naturally the main study of Darwin, is of comparatively little interest to us, and will not be hereafter referred to, but many of the principles of sterility find strong support in the special sterility of hybrids.Viewing the subject generally, we may anticipate a great result by pointing out the paramount prevalence and paramount potency of constitutional conditions as causes of sterility.Such are cold and heat, overfeeding and underfeeding, youth and old age, degradation of general health, confinement, and interbreeding.Local conditions occur in plants that are quite sufficient to account for or cause sterility.Such are contabescence of anthers, monstrous flowers, double flowers, seedless fruit.These local conditions are the result of the general or constitutional conditions of the indi- viduals in which they occur; and they have their place rather in the results of sterility, or of the conditions producing sterility, than in the causes of sterility.They have their analogues in such abortions, dead feetuses, unhealthy offspring, or monstrous products of animals, as are believed to be results of what may be called the sterile dia-
Observations on Effect of Spironolactone in Edema Associated with Renal Disease
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
General psychiatry. A primary-care specialty
Authors: D. Oken
Journal: JAMA (1976)

PRIMARY care currently has captured much attention. The need for more front-line physicians is clear, although it is but one piece in the jigsaw of health care. But what are the primary-care specialties? Thoughtful examination of the basic issues as they relate to the current practice of general psychiatry leads to an inescapable conclusion that this field belongs among the primary-care specialties. Because that fact is so inadequately appreciated, the present explanation is provided. The primary care concept has developed rapidly, and no single definition for it exists. Nevertheless, there are several thoughtful analyses of its essential features<sup>1-6</sup>and one of them has achieved semiofficial status.<sup>5</sup>A review of these indicates that three broad criteria are subsumed: (1) Initial contact and care.—The physician of first contact who assesses the situation and provides care for as many problems as possible. (2) Integration.—The physician who coordinates the remainder of the
The Future Challenge of Lead Toxicity
Authors: Herbert L. Needleman
Journal: Environmental Health Perspectives (1990)

Five decades ago, lead toxicity in childhood was thought in nonlethal cases to be without residual effect. This misconception was corrected in 1943 by Randolph Byers, who began the modern era of lead neurotoxicology by asserting that lead not only killed cells, but interfered with the normal development of central nervous system neurons. The human data from Byers forward is reviewed, with particular attention on methodological issues that have emerged. The papers on human neurotoxicology presented at the NIEHS lead conference held in Research Triangle Park, NC, in 1974 are examined to demonstrate the progress made over the last 15 years. Seven methodological solecisms have clouded judgment over the question of lead toxicity at low dose: worship of the sacrament of p = 0.05; inaccurate causal modeling; drawing conclusions from studies with inadequate power; positing phantom covariates; underestimating the importance of "small" effects; demanding proof of causality; and evaluating studies in isolation. The principles behind these errors are discussed. Lead exposure is associated with hyperactivity, and hyperactivity is a risk factor for antisocial behavior. The relationship between lead exposure and antisocial behavior is estimated. A plan for the effective removal of one major lead source, housing stock, is presented.