tbuckley/cabot-search huggingface dataset:
P3BEP (ANZUP 1302): An international randomised phase 3 trial of accelerated versus standard BEP chemotherapy for adult and paediatric male and female patients with intermediate and poor-risk metastatic germ cell tumours (GCTs).
Authors: Peter S. Grimison, Nicola Jane Lawrence, Martin R. Stockler, Andrew James Martin, Sonia Yip, Nicole Wong, Annie Yeung, Michael Friedlander, Danish Mazhar, Farzana Pashankar, David I. Quinn, Ray McDermott, Rick Walker, Mark Winstanley, Fritha J. Hanning, Andrew James Weickhardt, Amanda Gwendolyn Stevanovic, Ian D. Davis, Guy C. Toner
Journal: Journal of Clinical Oncology (2018)

TPS4596 Background: Bleomycin, etoposide, cisplatin (BEP) given 3-weekly x 4 remains standard 1st line chemotherapy for metastatic GCTs. Acceleration of standard regimen with shorter cycle lengths has improved cure rates in other cancers. This is the first international randomised clinical trial for intermediate and poor-risk metastatic extracranial GCTs involving both adult and paediatric age group males and females. We aim to determine if accelerated BEP is superior to standard BEP. Methods: DESIGN: Open label, randomised, stratified multicentre, 2 stage, phase 3 trial. Primary endpoint for stage I (n = 150) is complete response rate (RR), and for entire trial (n = 500) is progression free survival (PFS). SAMPLE SIZE: 150 and 500 patients gives > 80% power to detect a 20% improvement in RR and 7% absolute improvement in 2yr PFS, respectively. POPULATION: Males and females aged 11-45 years with intermediate or poor-risk metastatic GCTs of the testis, ovary, retroperitoneum or mediastinum for 1st line chemotherapy. TREATMENT: Randomisation 1:1 to 4 cycles of “standard BEP” or “accelerated BEP”: cisplatin 20mg/m2 IV D1-5; etoposide 100mg/m2 IV D1-5; bleomycin 30000 IU IV weekly; and pegylated G-CSF SC D6 or Filgrastim daily; given every 3 weeks or every 2 weeks respectively. Accelerated BEP arm receives 4 additional weekly doses of bleomycin. ASSESSMENTS: Response assessments at 30 day safety assessment, and 6 months from randomisation or after all post-chemotherapy intervention is completed. Regular follow-up up to 5 years, then annually. Archival tumour tissue and baseline blood collected for translational substudies. STATUS: 25 sites open in ANZ, 4/21 sites open in UK (led by Cambridge Clinical Trials Unit), 46 patients recruited by February 2018. International collaboration with USA (led by Children’s Oncology Group) is confirmed with sites expected to open by mid2018 and more sites sought for stage 2. Clinical trial information: NCT02582697.
男性化激素治疗的副作用
Authors: C.C. Motosko, G.A. Zakhem, M.K. Pomeranz, A. Hazen
Journal: British Journal of Dermatology (2019)

痤疮是在变性男性中进行男性化激素治疗时的已知副作用。在所有痤疮患者中,它和抑郁、身体意象问题乃至自杀意念有关。激素,尤其是睾酮,通常是性别焦虑症的首选治疗,性别焦虑症是变性男性中可能因为感觉和表达的性别与实际性别的差异而导致的不安。这些激素可能加重痤疮以及毛发和皮肤问题。这篇来自美国的文章的目的是,增进对因男性化激素疗法而发生痤疮的变性男性的建议和治疗的理解。研究显示,痤疮的严重程度在治疗的前 4 个月内达到高峰。尽管在第一年内发现改善,但痤疮仍可能持续存在,在睾酮治疗开始后持续数年。痤疮的严重程度并不一致,大部分患者经历较轻的皮损(痘痘)。痤疮通常在背部和胸部最为突出,这些部位可能已成为造成变性男性不满意的最大来源之一。可以使用标准痤疮疗法治疗,如局部外用药物(乳膏)和抗生素,但激素治疗可能与变性男性中睾酮的预期疗效发生相互作用,需要谨慎考虑并进行讨论。如果在这些一线治疗后并未改善,一种称为异维甲酸的强效药物在接受男性化治疗的患者中有效,但可能需要接受多个疗程的治疗。这种药物可能导致不良的副作用,医生们必须密切监测使用此药的患者。此研究针对医生讨论了其他重要考量。尽管痤疮的治疗选择与在原性别者(个人身份和性别感与他们出生时的性别相符)中使用的治疗选择相似,在治疗变性患者时必须注意多种医学、社会和心理考量。
Semantic paralysis
Authors: Fred Adams
Journal: Behavioral and Brain Sciences (2003)

I challenge Jackendoff's claim that semantics should not be paralyzed by a failure to solve Brentano's problem of intentionality. I argue that his account of semantics is in fact paralyzed because it fails to live up to his own standards of naturalization, has no account of falsity, and gives the wrong semantic objects for words and thoughts.
Defective hepatic mitochondrial respiratory chain in patients with nonalcoholic steatohepatitis
Authors: M Pérez-Carreras
Journal: Hepatology (2003)

Mitochondrial dysfunction might play a central role in the pathogenesis of nonalcoholic steatohepatits (NASH). The aims of this study were to evaluate whether free fatty acid (FFA) transport into the mitochondria or the activity of mitochondria respiratory chain (MRC) complexes are impaired in NASH. In patients with NASH and control subjects, we measured free carnitine, short-chain acylcarnitine (SCAC) and long-chain acylcarnitine (LCAC) esters, carnitine palmitoyltransferase (CPT) activity, and MRC enzyme activity in liver tissue as well as serum concentration of tumor necrosis factor α (TNF-α), homeostatic metabolic assessment of insulin resistance (HOMAIR), and body mass index (BMI). In patients with NASH, the LCAC/free carnitine ratio was significantly increased and the SCAC/free carnitine ratio was decreased. In patients with NASH, the activity of the MRC complexes was decreased to 63% ± 20% (complex I), 58.5% ± 16.7% (complex II), 70.6% ± 10.3% (complex III), 62.5% ± 13% (complex IV), and 42.4% ± 9.1% (adenosine triphosphate synthase) of the corresponding control values. Activity of these complexes correlated significantly with serum TNF-α and HOMAIR. Serum TNF-α (36.3 ± 23.1 pg/mL), HOMAIR (4.5 ± 2.38), and BMI (29.9 ± 3.5 kg/m2) values were significantly increased in patients with NASH. In conclusion, activities of MRC complexes were decreased in liver tissue of patients with NASH. This dysfunction correlated with serum TNF-α, insulin resistance, and BMI values. (Hepatology 2003;38:999–1007).
Thyroid hormone and breast cancer
Authors: William F. Taylor, Alvin B. Hayles
Journal: JAMA (1977)

<h3>To the Editor.—</h3> We have had opportunity to study the letters by Drs Venezian and MacCornack and to reconsider the two articles they discuss, which deal with the prevalence of breast cancer in women who have had thyroid hormone treatment of various durations. We write this letter as a result of comments by some of our colleagues that they could not understand the data analyses in these documents. Only in the initial paper by Kapdi and Wolfe were the data both clearly presented and analyzed (albeit somewhat incompletely). We do not quarrel with the methodology or the arithmetic of this material. What bothers us is that there was no simple, commonsense presentation of the data. We suggest that the data provided by Kapdi and Wolfe could have been presented so that understanding would be both correct and immediate. The essentials are the relations of prevalence (percentage of women with breast
Epidemics of Cholera and Yellow Fever.
Journal: JAMA (1884)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medicolegal
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reference Directories
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cardiovascular risk and use of estrogens or estrogen-progestagen combinations. Stanford three-community study
Authors: M. P. Stern
Journal: JAMA (1976)

Cardiovascular risk factors were assessed in 986 women residing in three northern California communities. Women who reported current use of oral contraceptives had higher plasma triglyceride levels and systolic and diastolic blood pressures compared with women not using these agents, after adjusting for age and for the greater relative leanness of oral contraceptive users. Similar increases, albeit of lesser magnitude, were observed in women who used pure estrogens. Mexican-American women appeared to be more susceptible to the effects of estrogens, perhaps as a consequence of their greater degree of obesity. (<i>JAMA</i>235:811-815, 1976)
Simultaneous Streptococcus and picornavirus infection. Muscle involvement in acute rhabdomyolysis
Authors: C. B. Porter
Journal: JAMA (1981)

Streptococci seldom invade muscle in healthy people with intact integument. However, infection with another agent simultaneously may change this general observation. In a two-week period we encountered dual infections with group A, β-hemolytic streptococci and a picornavirus in each of two hospitalized patients. Both were acutely ill; one died. Renal failure developed in the patient who survived and rhabdomyolysis was demonstrated in the patient who died. Picornavirus titer increases were demonstrated in the patient who survived, and viral inclusions in muscle cells were demonstrated by light microscopy in necropsy specimens and confirmed by electron microscopy in the second patient. We believe that streptococcal invasion of muscle may be facilitated during an outbreak of certain picornavirus infections. (<i>JAMA</i>1981;245:1545-1547)
Stat Bite: State Mammography, Reimbursement Legislation
Journal: JNCI Journal of the National Cancer Institute (1993)

Stat Bite: State Mammography, Reimbursement Legislation Get access JNCI: Journal of the National Cancer Institute, Volume 85, Issue 8, 21 April 1993, Page 605, https://doi.org/10.1093/jnci/85.8.605-a Published: 21 April 1993
Ophthalmology
Authors: Edwin B. Dunphy
Journal: New England Journal of Medicine (1945)

THE following ophthalmologic subjects have been selected as being of general interest. Some of them are not new, but because of recently revived interest in them, they were thought to deserve review.Relation of German Measles to Congenital CataractsOne of the most interesting recent developments in the field of ophthalmology has been the recognition of the fact that congenital cataracts can be caused by German measles occurring in the mother early in pregnancy. Gregg,1 of Sydney, was the first to point out this relation, and in 1941 he reported a series of cases to the Ophthalmological Society of Australia. . . .
European Scientific Conference on Applied Infectious Disease Epidemiology (ESCAIDE) 2014 - call for abstracts
Authors: Collective Eurosurveillance editorial team
Journal: Eurosurveillance (2014)

Preview this article: European Scientific Conference on Applied Infectious Disease Epidemiology (ESCAIDE) 2014 - call for abstracts, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/19/18/art20794-en-1.gif
Family (parental) history and prevalence of hypertension. Results of a nationwide screening program
Authors: R. Stamler
Journal: JAMA (1979)

In a nationwide screening program, blood pressure measurements, family (parental) histories of hypertension, and self-evaluations of weight class were obtained for more than a half million people. Positive family history was associated with hypertension prevalence double that found in persons with negative history and was independent of weight. When overweight was also present, however, hypertension prevalence was three to four times as high. Hypertension was more likely to have been previously diagnosed in screenees if family history was positive. However, such screenees did not have a higher proportion receiving effective treatment than those with negative family history. When an index case of hypertension is found, other family members should be examined. For persons with positive family history, nutritional-hygienic recommendations to avoid overweight may be important in reducing the risk of becoming hypertensive. (<i>JAMA</i>241:43-46, 1979)
Abstract 452: Primary Left Ventricular Unloading Reduces Infarct Size by Increasing Myocardial Levels of Stromal Derived Factor One Alpha (SDF1a) in Acute Myocardial Infarction
Authors: Yali Zhang, Michele Esposito, Xiaoying Qiao, Vikram Paruchuri, Emily Mackey, Kevin Morine, Gavin Schnitzler, Lara Reyelt, Courtney Boggins, Noam Josephy, Richard H Karas, Navin K Kapur
Journal: Circulation Research (2017)

Stromal derived factor 1 alpha (SDF1a) is a constitutively expressed cardioprotective chemokine that is rapidly degraded by proteases. We reported that compared to Primary Reperfusion (PR), first reducing myocardial oxygen demand by activating a trans-valvular pump (Impella CP) while delaying coronary reperfusion (Primary Unloading; PU) reduces infarct size in acute myocardial infarction (AMI). We now hypothesize that PU reduces proteolytic degradation of SDF1a thereby increasing SDF1a signaling via the receptor CXCR4 in AMI. Methods: AMI was induced by occlusion of the left anterior descending artery (LAD) for 90 min in male swine (n=4/group). In the PR group, the LAD was reperfused for 120 min. In the PU group, after 90 min of ischemia an Impella CP was activated and the LAD left occluded for an additional 30 min, followed by 120 min of reperfusion. Whole-transcript expression analysis was performed on RNA from the infarct zone using Porcine 1.0 ST microarrays and ConsensusPathDB programs. Quantitative polymerase chain reaction, western blots, and activity assays determined expression and activity of the SDF1a signaling pathway. Sham operated LV samples served as controls. Results: Compared to PR, PU reduced fibrotic and inflammatory gene expression including reduced transcript levels of matrix-metalloprotease-2 (MMP2), MMP9 and dipeptidyl peptidase-4 (DPP4). Compared to PR, PU increased SDF1a protein levels within the infarct zone. Gel zymography confirmed reduced activity levels of MMP2 and MMP9 within the infarct zone after PU, not PR. Compared to PR, PU attenuated DPP4 protein levels and activity and protein levels of CXCR7, an SDF1a sequestration receptor, within the infarct zone. To explore a functional role for SDF1a in PU, adult male swine received intra-coronary injections of AMD3100, a CXCR4 receptor antagonist, after Impella CP activation. Loss of CXCR4 activity attenuated cardioprotective signaling via Akt, Erk and GSK3b and increased infarct size compared to vehicle treated controls. Conclusion: We introduce a novel mechanism by which PU limits proteolytic degradation and CXCR7 mediated sequestration of SDF1a, thereby increasing cardioprotective signaling via SDF1a and overcoming a critical barrier to SDF1a therapeutics in AMI.
Diagnosis of human immunodeficiency virus infection in seronegative homosexuals presenting with an acute viral syndrome
Authors: H. A. Kessler
Journal: JAMA (1987)

Early diagnosis of acute human immunodeficiency virus (HIV) infection is difficult because patients may be seronegative for HIV at the time of presentation. We have used a serum HIV antigen (HIV-Ag) enzyme immunoassay (EIA) to diagnose acute HIV infection in four high-risk patients. The clinical syndrome in these four patients was characterized by fever (four), rash (three), myalgiasarthralgias (three), and pharyngitis (two). All patients had spontaneous resolution of their symptoms within eight to 12 days. Serum HIV antibody, as measured by a commercially available screening EIA and by Western blot analysis, was negative in all patients at time of presentation and all seroconverted on subsequent testing. Human immunodeficiency virus was isolated from two of two patients during the acute illness. Initial serum samples from all four patients were positive for HIV-Ag. Serum samples of three of four patients became negative for HIV-Ag and positive for HIV antibody. These data suggest that serum HIV-Ag detection by EIA may be useful in the diagnosis of the acute syndrome caused by HIV infection. (<i>JAMA</i>1987;258:1196-1199)
International Comments
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CORRESPONDENCE
Authors: H. RADCLIFFE CROCKER
Journal: British Journal of Dermatology (1902)

Journal Article CORRESPONDENCE Get access H. RADCLIFFE CROCKER H. RADCLIFFE CROCKER 121, Harley Street Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 14, Issue 9, 1 September 1902, Page 366, https://doi.org/10.1111/j.1365-2133.1902.tb16467.x Published: 01 September 1902
Commentaire de travail de A. Imagawa et al., pp. 905
Journal: Endoscopy (2008)

See also: Satisfaction with bispectral index monitoring of propofol-mediated sedation during endoscopic submucosal dissection: a prospective, randomized studyEndoscopy 2008; 40(11): 905-909DOI: 10.1055/s-2008-1077641
HEALTH IN THE ARMY
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fees
Journal: JAMA (1984)

<h3>To the Editor.—</h3> I refer to the article entitled "A Strategy for Cost Containment in Coronary Surgery" by Loop et al.<sup>1</sup>I think it is a notable article reflecting a noble cause with a salutary effect on cost containment. The editorial by Dr Egdahl also raised important issues regarding surgical fees, especially in cardiac surgery. The fact that the government's plan to reduce the cost of medical care includes plans to decrease physician revenue is overlooked. I believe that Dr Egdahl's suggestion that open discussion, without the threat of antitrust action, might result in some downward revision of surgical fees is naive. In 22 years I have yet to see substantial reduction in any surgical fee, most especially cardiac surgery. The entire process of establishing surgical fees is wondrous and mysterious. It really resolves down to more or less picking a number. For instance, one coronary vein graft is
Renal-artery abnormalities in three hypertensive sisters. Probable familial fibromuscular hyperplasia
Authors: M. M. Halpern
Journal: JAMA (1965)

Angiographic findings in three female siblings, ages 45, 48, and 52, suggested fibromuscular hyperplasia of the renal arteries. A hereditary developmental weakness of the renal artery may be an etiologic factor of this pathological abnormality.
Use of Smokeless Tobacco Among Adults— United States, 1991
Journal: JAMA (1993)

Consumption of moist snuff and other smokeless tobacco products in the United States almost tripled from 1972 through 1991 (1). Long-term use of smokeless tobacco is associated with nicotine addiction and increased risk of oral cancer (2)--the incidence of which could increase if young persons who currently use smokeless tobacco continue to use these products frequently (1). To monitor trends in the prevalence of use of smokeless tobacco products, CDC's 1991 National Health Interview Survey-Health Promotion and Disease Prevention supplement (NHIS-HPDP) collected information on snuff and chewing tobacco use and smoking from a representative sample of the U.S. civilian, noninstitutionalized population aged > or = 18 years. This report summarizes findings from this survey.