tbuckley/cabot-search huggingface dataset:
GERMANY
Journal: JAMA (1963)

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Symphysiotomy Successfully Performed under Difficulties
Journal: JAMA (1893)

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Characterization of patients (pts) with poor risk metastatic renal cell carcinoma (mRCC): Results from a pooled clinical trials database.
Authors: Lana Hamieh, Rana R. McKay, Xun Lin, Ronit Simantov, Toni K. Choueiri
Journal: Journal of Clinical Oncology (2017)

515 Background: Survival outcomes are heterogeneous across different subsets of mRCC pts. Poor risk pts have grim outcomes and are less likely to be enrolled in clinical trials, hence the lack of prospective data characterizing this pt population. We provide a comprehensive analysis of poor risk pts, as defined by three widely used prognostic models, in the era of targeted therapy. Methods: We conducted a pooled retrospective analysis of 4,736 mRCC pts treated on phase II and III clinical trials. Pts were defined as poor risk according to the Memorial Sloan Kettering Cancer Center (MSKCC), International Metastatic Database Consortium (IMDC), and Hudes prognostic risk models. We evaluated overall survival (OS), progression-free survival (PFS), objective response rate (ORR), and adverse events (AEs) in poor risk pts in each of the risk models in the total cohort and in a subset of pts who remained on treatment for &gt;12 months (mos). The models’ concordance (c-) index was used to assess their prognostic performance. Results: We identified 1145 (24.2%), 904 (19.1%), and 1901 (40.1%) poor risk pts by IMDC, MSKCC, and Hudes models, respectively. The majority were &lt;65 years of age (70-73%) with clear-cell histology (85-88%), prior nephrectomy (62-66%), and no prior systemic therapy (80-86%). The efficacy and toxicity outcomes as well as the c-indexes for each of the models are reported in the table below. Additionally, 9-14% of poor risk pts remained on therapy for &gt;12 mos and had higher OS (29.8-35.2 mos) and ORR (42-53%). Conclusions: In this large database of poor risk mRCC pts, we highlight that the models have similar predictive accuracy in the targeted therapy era. We also demonstrate that poor risk pts continue to have dismal outcomes and should be considered for trials of novel agents and combinations. A subset of these pts appears to derive prolonged clinical benefit and should be further explored.[Table: see text]
Developmental Pathways: Sonic Hedgehog-Patched-GLI
Authors: David O. Walterhouse, JoonWon Yoon, Philip M. Iannaccone
Journal: Environmental Health Perspectives (1999)

Developmental pathways are networks of genes that act coordinately to establish the body plan. Disruptions of genes in one pathway can have effects in related pathways and may result in serious dysmorphogenesis or cancer. Environmental exposures can be associated with poor pregnancy outcomes, including dysmorphic offspring or children with a variety of diseases. An important goal of environmental science should be reduction of these poor outcomes. This will require an understanding of the genes affected by specific exposures and the consequence of alterations in these genes or their products, which in turn will require an understanding of the pathways critical in development. The ligand Sonic hedgehog, the receptors Patched and Smoothened, and the GLI family of transcription factors represent one such pathway. This pathway illustrates several operating principles important in the consideration of developmental consequences of environmental exposures to toxins.
FINLAND
Journal: JAMA (1962)

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SCARLET FEVER AND MILK.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Cerebrospinal Fluid: Production, Circulation and Absorption.
Journal: Annals of Internal Medicine (1960)

So excellent and widely known a textbook as Muir's needs little write-up from any reviewer, and, in the capable hands of Professor Cappell, the traditions of the work as a contemporary survey of the subject are admirably maintained.Since the last edition was published in 1951 a good deal of new material has collected.This has called for radical revision of the text, and the modest addition of 111 pages has meant the curtailment of topics of decreasing clinical importance, but a good proportion of these extra pages is to be accounted for by the addition of 100 illustrations.The transfer of the section on repair of fractures to the more general chapter on inflammatory pro- cesses, the addition of a note on the collagen diseases, and the modernization of the section on fluid and electrolyte balance are but random examples testi- fying to the thoroughness of the revision.The treat- ment of diseases of the blood, which includes the more recent immunological researches in haematology, is particularly to be commended.In general this is a text upon which the undergraduate student may confidently rely.
Maternal and neonatal Graves' disease
Authors: L. J. Elsas
Journal: JAMA (1967)

LONG-ACTING thyroid stimulator (LATS)<sup>1</sup>has been found in the serum of five children with neonatal thyrotoxicosis.<sup>2-5</sup>The maternal serum was also positive for LATS in these cases, which led to the hypothesis that neonatal thyrotoxicosis was caused by LATS crossing the placenta and reaching the fetal circulation.<sup>5</sup>This hypothesis was used to explain the self-limited nature of neonatal thyrotoxicosis which usually resolved spontaneously within 3 to 12 weeks, a course which correlated with the estimated half-life of LATS (six to seven days in neonatal serum).<sup>2</sup>Some infants with neonatal thyrotoxicosis have had hepatosplenomegaly,<sup>6</sup>congestive heart failure,<sup>7</sup>jaundice,<sup>8</sup>and thrombocytopenia.<sup>9</sup>Although these findings could be due to other causes, they have occurred often enough with neonatal Graves' disease to suggest more than a chance association. The present study is, to our knowledge, the sixth reported case of neonatal thyrotoxicosis associated with LATS in
AB0277 Assessment of global disease activity in RA patients monitored in the meteor database: The patient’s versus the rheumatologist’s opinion:
Authors: E. Gvozdenović, R. Koevoets, D. van der Heijde, T. Huizinga, R. Allaart, R. Landewé
Journal: Annals of the Rheumatic Diseases (2012)

<h3>Background</h3> Disagreement on disease activity between rheumatoid arthritis (RA) patients and rheumatologists may influence treatment decisions and compliance. <h3>Objectives</h3> To compare -and identify determinants of- the assessment of disease activity on a visual analogue scale (VAS, 0=best possible, 100=worst possible) by patients (VAS-pt) and physicians (VAS-phy), and to investigate if they are influenced by time. <h3>Methods</h3> Anonymous data were used from 2118 Dutch patients included in the METEOR database, a worldwide online tool for disease monitoring in RA. Intra-class correlation coefficients (ICC) were calculated as a measure of agreement and a Bland Altman plot was created to visualize the differences between VAS-pt and VAS-phy. Linear Mixed Model analysis was used to model the VAS-pt and VAS-phy over time. Gender, age, HAQ, swollen joint count, tender joint count, VAS pain, disease duration and BSE were considered as possible determinants of the VAS-pt or VAS-phy. <h3>Results</h3> Mean age was 57 years (SD: 15) and 67% of the patients were female. Correlation between VAS-pt and VAS-phy was moderate (ICC 0.61; p&lt;0.01). Patients score on average 11 points higher (worse) than rheumatologists at the first registered visit (95% limits of agreement: -25.2 to 47.6). Scores were increasingly discordant towards the higher end of the scale. Both VAS-phy and VAS pt increase by the tender joint count, HAQ-score and patient's VAS for pain. VAS-phy, but not VAS-pt, also increases by swollen joint count. VAS-phy decreases by disease duration, and VAS-pt showed a similar trend. <h3>Conclusions</h3> Patients score VAS disease activity systematically higher than rheumatologists, although patients' and physicians' VAS are more or less associated with the same determinants: HAQ-score, tender joint count and VAS pain. But physicians put more weight on swollen joint count, and score lower disease activity over time, whilst patients do not. <h3>Disclosure of Interest</h3> None Declared
在潮湿环境下工作的医护人员的手部湿疹问题:一项横断面研究
Authors: N. Hamnerius, C. Svedman, O. Bergendorff, J. Björk, M. Bruze, A. Pontén
Journal: British Journal of Dermatology (2018)

手部湿疹是医护人员的常见问题。一个原因是,他们需要经常接触肥皂和水。在过去的十年中,为了防止传染病的蔓延,医疗机构中实施了更加严格的卫生措施。此项研究的目的在于证明一次性手套、酒精手消毒剂和肥皂的使用与手部湿疹的关系。研究人员向瑞典南部所有医院职工发送了电子版问卷调查。该项分析中仅包含了职务为护士、助理护士和医生的调查对象。在此群体中,有21%的人表示在过去的12个月中曾经有过手部湿疹,这一比例要高于一般人群。30%的人每天在工作中用肥皂洗手超过20次,54%的人每天使用非灭菌一次性手套超过两小时,还有45%的人每天使用酒精手消毒剂超过50次。手部湿疹更常见于频繁使用肥皂和长时间使用一次性手套的人。但手部湿疹与使用酒精消毒剂并无关联。此项研究显示,手部湿疹在医护人员中仍然非常常见。需要制定预防手部湿疹的教育计划。
Leads from the MMWR. Influenza vaccine composition recommendation for the 1989-90 season
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE CAFFREY BILL.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Author Index Vol. 72, 2003
Authors: Franco Benazzi, Masayo Kojima, Yoshihiro Senda, Teruo Nagaya, Shinkan Tokudome, Gudrun Schneider, Georg Driesch, Andreas Kruse, Michael Wachter, Hans-Georg Nehen, Gereon Heuft, Willeke H. van Zelst, Edwin de Beurs, Aartjan T.F. Beekman, Dorly J.H. Deeg, Richard van Dyck, Peter Tyrer, Tom Sensky, Sarah Mitchard, David Healy, David MacLean, Chiara Rafanelli, Renzo Roncuzzi, Livio Finos, Eliana Tossani, Elena Tomba, Lara Mangelli, Stefano Urbinati, Giuseppe Pinelli, Giovanni A. Fava, Zoltán Rihmer, Franco Benazzi, Angelo Picardi, Mohammad Reza Namazi, Richard Balon, Karina W. Davidson, Paul Rowan, Cheryl Barksdale, Toshiaki A. Furukawa, Michael William MacGregor
Journal: Psychotherapy and Psychosomatics (2003)
The beginning of the end of AIDS?
Authors: None The Lancet
Journal: The Lancet (2012)

Louis Pasteur, the father of microbiology, once stated "it is within the power of man to eradicate infection from the earth". Indeed, the world has already achieved the great triumphs of eradication of smallpox in 1979 and rinderpest in 2011. After three decades of global emergency responses and a series of scientific breakthroughs in the fight against HIV/AIDS, it is now tempting to ask if we are marching towards the end of AIDS.
THE BRITISH GYNECOLOGICAL SOCIETY REFUSES ADMISSION TO WOMEN.
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Editorial: Diet and colonic cancer.
Journal: BMJ (1974)

Coping with Minor Casualties Doctors may be convinced that their case for shorter working hours is fully justified, but patients tend to be aggrieved if they cannot get medical attention at night and at weekends.With rare exceptions, the victim of an acute, serious medical or surgical emergency gets good treatment from the N.H.S.; but the child bitten by a dog or the cyclist with a speck of grit in his eye may have great difficulty in finding a doctor at all on a Sunday afternoon.This problem came before the House of Commons Ex- penditure Committee during its examination of the accident and emergency services,' and its report is provocative but essentially reasonable.It followed the view of the 1962 Platt Committee2 that hospital accident departments should deal primarily with serious cases and that the flow of minor cases "should be reduced by the operation of an adequate general practitioner service at all times."In practice, the committee was told, casual attenders with relatively trivial complaints may constitute as much as 50% of the case load of a casualty
Errors in Byline, Affiliations, and Conflict of Interest Disclosures
Journal: JAMA Network Open (2020)

Sabine Schmid, MD; Aurelius Omlin, MD; Celestia Higano, MD; Christopher Sweeney, MD; Nieves Martinez Chanza, MD; Niven Mehra, MD; Malou C. P. Kuppen, MD; Himisha Beltran, MD; Vincenza Conteduca, MD; Daniel Vargas Pivato de Almeida, MD; Fernando Cotait Maluf, MD; William K. Oh, MD; Che-Kai Tsao, MD; Oliver Sartor, MD; Elisa Ledet, MD; Giuseppe Di Lorenzo, MD; Steven M. Yip, MD; Kim N. Chi, MD; Diletta Bianchini, MD; Ugo De Giorgi, MD; Aaron R. Hansen, MD; Tomasz M. Beer, MD; Pernelle Lavaud, MD; Rafael Morales-Barrera, MD; Marcello Tucci, MD; Elena Castro, MD; Kostas Karalis, MD; Andries M. Bergman, MD; Mo Linh Le, MD; Ursina Zürrer-Härdi, MD; Carmel Pezaro, MD; Hiroyoshi Suzuki, MD; Andrea Zivi, MD; Dirk Klingbiel, PhD; Sämi Schär, PhD; Silke Gillessen, MD
PLoS Medicine Issue Image | Vol. 6(6) June 2009
Journal: PLoS Medicine (2009)

At the March 2009 United Nations meetings coinciding with the World Water Forum, a declaration that would recognize water as a basic human right was defeated. In this month's Editorial, the PLoS Medicine Editors argue that access to clean water should be declared a basic human right for three reasons. First, access to clean water can substantially reduce the global burden of disease caused by water-borne infections. Second, the privatization of water—as witnessed in Bolivia, Ghana, and other countries—has not effectively served the poor, who suffer the most from lack of access to clean water. Third, the prospect of global water scarcity—exacerbated by climate change, industrial pollution, and population growth—means that no country is immune to a water crisis. Image Credit: Rudhach at flickr.com