tbuckley/cabot-search huggingface dataset:
Actinomyces in vaginal smears
Authors: P. K. Gupta
Journal: JAMA (1982)

The intrauterine device (IUD) is recognized as an effective, economical, and safe method of reversible contraception. It is the second most commonly used contraceptive method in the United States. Early 19th-century designs made of pewter and platinum have been replaced by plastic devices that may be medicated and may contain copper or hormones. Their effectiveness is apparently related to disturbance in endometrial function, implantation, or both. Although the physical forms vary, all such devices currently have a monofilamentous synthetic "tail" with which the IUD may communicate with the external environment. Additionally, the device may alter the intrauterine milieu, thus making it more conducive for the growth of certain microorganisms. <i>Actinomyces</i>belong to the family of higher bacteria and are susceptible to antibiotics. These anaerobes have been observed in the vaginal smears of current or immediate past users (within six to eight weeks) of IUDs (R. T. Burkman, MD, and colleagues,
The Care of the Aged (Geriatrics)
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lymphoma immunotherapy: Efficacy, safety and accessibility to CAR‐T therapy for lymphomas
Authors: Peter Borchmann
Journal: HemaSphere (2018)

1st Department of Internal Medicine, University Hospital of Cologne, Germany This is an open access Abstract Book distributed under the Attribution-NonCommercial-NoDerivs (CCBY-NC-ND), which allows third parties to download the abstracts and share them with others as long as they credit the author and the abstract book, but they cannot change the content in any way or use them commercially. http://creativecommons.org/licenses/by-nc-nd/4.0
Revisiting Three Mile Island
Journal: Environmental Health Perspectives (1997)

Revisiting Three Mile IslandNearly 18 years have passed since a radioactive plume escaped from Reactor 2 on Three Mile Island in Harrisburg, Pennsylvania, and dissipated into the atmosphere, but the debate over the potential health effects from the United States' worst commercial nuclear accident continues.In this issue of EHP, epidemiologists from the University of North Carolina at Chapel Hill (UNC) reevaluate the data from a 1990 study that concluded that no association between the accident and cancer was apparent in the surrounding population.According to that report, published in the September 1990 issue of the American Journal ofEpidemiology, "The prior expecta- tion based on estimated releases and conven- tional radiobiology-that no excess cancer [associated with the accident] would be found-was confirmed in most if not all respects.But according to Steve Wing, one of the authors of the new study, it was precisely Rethinking old data.A researcher takes Geiger counti from the Susquehanna River near the Three Mile Isla power plant in 1979.
A Correction
Journal: BMJ (1912)

BIP Quteries, answvers, and com7lmunications relatting to su)bects to wchich special departmnents of the BRITISII MEDICAL JOURNAL are devoted wvill be fouomul un(ler thoeir respective headinigs. ANSWERS.ABERDONENSIs.-Formerly,wiheti C.M. was a necessary accom- pailiment of M
Postexercise Peril
Authors: Guy R. Banta
Journal: JAMA (1984)

<h3>To the Editor.—</h3> The article by Dimsdale et al<sup>1</sup>describing postexercise cardiac morbidity and its relation to plasma catecholamines is of interest but in need of discussion. I agree that the catecholamine tide after maximum exercise may adversely affect patients with coronary ischemia and should be considered when prescribing exercise to the unfit. The possible increased risk of arrhythmias and ischemia for everyone who exercises, however, is debatable. Hartley et al<sup>2</sup>and Winder et al<sup>3</sup>have shown that the magnitude of catecholamine increase during strenuous exercise is significantly less in enduranced-trained persons. Even Hagberg et al<sup>4</sup>(a reference cited by Dimsdale) showed that the one-minute postexercise norepinephrine concentration was less in trained persons than in untrained. Unfortunately, the correction for intersubject variance in Dimsdale's study eliminated any possibility of addressing this. It would have been valuable if the blood pressure-norepinephrine level correlations were compared with aerobic
THE EFFECTS OF SULPHONAMIDE COMPOUONDS UPON LUPUS ERYTHEMATOSUS.
Authors: H. W. BARBER
Journal: British Journal of Dermatology (1941)

Journal Article THE EFFECTS OF SULPHONAMIDE COMPOUONDS UPON LUPUS ERYTHEMATOSUS. Get access H. W. BARBER, M.A., M.B., B.Ch.Cantab., F.R.C.P.Lond. H. W. BARBER, M.A., M.B., B.Ch.Cantab., F.R.C.P.Lond. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 53, Issue 2, 1 February 1941, Pages 33–45, https://doi.org/10.1111/j.1365-2133.1941.tb10496.x Published: 01 February 1941
Plain language summaries
Journal: British Journal of Dermatology (2016)

While it is well known that environmental and lifestyle factors like sun exposure can increase a person's risk of developing melanoma skin cancer, the risk is also influenced by genetic factors.This includes a person's natural skin colour (phenotype) which is decided by their genes, as well as whether they carry certain gene variants (their genotype) which may be linked to a high risk of melanoma.This study looked at the roles of phenotype, genotype and lifestyle in 1668 Austrian people with melanoma, divided into 'high risk' or 'reference' groups.The patients defined as 'high risk' were those who had more than one melanoma, who has a family history of melanoma, or who developed melanoma while aged under 50.The reference group were all other melanoma patients.The researchers also looked at other factors, including: gender, skin reaction to sun exposure, hair and eye colour, childhood freckling, outdoor occupation, sunbed use, sunscreen use, number of sunburns from birth to age 10, time spent outdoors at leisure, tumour thickness and presence of a genetic variant known to be linked to melanoma.In total, 11.4% of all melanoma patients had at least one reported melanoma diagnosis in the family, 15.7% had more than one melanoma and 40.5% were diagnosed before the age of 50.The researchers found significant differences between the high risk and reference groups, and also between the high risk subgroups (positive family history, multiple primary melanomas and young age).Blond/reddish hair colour, childhood freckling and sunburns from age 0-10 were significantly associated with a family history of melanoma.Male gender was significantly associated with multiple melanomas.Patients with a positive family history were younger than the average of the entire study population.High risk patients more frequently carried red hair gene variants compared to the reference group (81.3% vs. 74.7%).When subgroups were analysed separately, patients with a family history had the highest number of genetic variations (86.2% vs. 74.7%).As there are different characteristics that define someone as high risk, a more precise description of each subgroup might lead to preventive measures that are better adjusted to individual needs.
JAMA Reader's Choice: Continuing Medical Education
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Differential Gene Expression during Multistage Carcinogenesis
Authors: G. Tim Bowden, Peter Krieg
Journal: Environmental Health Perspectives (1991)

The use of the mouse skin multistage model of carcinogenesis has aided our understanding of critical target genes in chemical carcinogenesis. The mutagenic activation of the Harvey-ras proto-oncogene has been found to be an early event associated with the initiation of mouse skin tumors by the polycyclic aromatic hydrocarbon 7,12 dimethylbenz[alpha]anthracene and the pure initiator ethyl carbamate (urethane). In contrast to chemical initiation of mouse skin tumors, ionizing radiation-initiated malignant skin tumors have been shown to possess distinct non-ras transforming gene(s). Differential screening of cDNA libraries made from chemically initiated malignant skin tumors has been used to identify a number of cellular gene transcripts that are overexpressed during mouse skin tumor progression. These differentially expressed genes include beta-actin, ubiquitin, a hyperproliferative keratin (K6), a gene whose product is a member of a fatty acid or lipid-binding protein family, and a gene called transin or stromelysin. The overexpression of the stromelysin gene, which encodes a metalloproteinase that degrades proteins in the basement membrane, is hypothesized to play a functional role in malignant tumor cell invasion and metastasis. We believe that the cloning, identification, and characterization of gene sequences that are differentially expressed during tumor progression could lead to the discovery of gene products that either play functional roles in skin tumor progression or in the maintenance of various progressive tumor phenotypes.
Detection of Cytogenetic Abnormalities Associated with Outcome Differences in Acute Myeloid Leukemia Using Array-Based Comparative Genomic Hybridization (aCGH) Analysis.
Authors: Keyur Patel, Farhad Ravandi, Deqin Ma, Hui Yao, Ronald Abraham, Bedia Barkoh, Sherry Pierce, Hagop Kantarjian, Rajyalakshmi Luthra
Journal: Blood (2009)
To Seek, per Chance to Find
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
"ANACIN"
Authors: J. A. Heidbrink
Journal: JAMA (1925)

<h3>To the Editor:</h3> —In the article on this subject, page 1079, October 3, it is stated that Dr. F. W. Wittich developed a formula for a "patent medicine" and allowed it to be put on the market for indiscriminate sale to, and the uncritical use by, the public. The undersigned is the president of the Heidbrink Company of Minneapolis, which is the owner of the Trade Mark "Anacin." This trade mark was acquired from a pharmacist in Minneapolis who claimed that the formula had been suggested to him by a number of prescriptions compounded by him for Dr. Wittich. This pharmacist had the name "Anacin" trade marked and he originated the name. For a short time the sales manager printed on direction sheets accompanying each package "From a prescription of Dr. Wittich," with the idea of conforming to a rather extensive practice at that time of so accounting for proprietary
BOOK REVIEWS
Authors: A. S. RABSON
Journal: JNCI Journal of the National Cancer Institute (1992)

BOOK REVIEWS Get access Origins of Human Cancer: A Comprehensive Review . Joan Brugge , Tom Curran , Ed Harlow , Frank McCormick , eds. Plainview, N.Y. : Cold Spring Harbor Lab. Press , 1991 . 904 pp., illus. $80. ISBN 0-87969-404-1 ALAN S. RABSON, M.D. ALAN S. RABSON, M.D. Division of Cancer Biology, Diagnosis, and Centers, National Cancer InstituteBldg. 31, Rm. 3A03, 9000 Rockville Pike Bethesda, MD 20892 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 84, Issue 21, 4 November 1992, Page 1661, https://doi.org/10.1093/jnci/84.21.1661 Published: 04 November 1992
Evaluation of dermal and respiratory chloroform exposure in humans
Authors: B Lévesque, P Ayotte, A LeBlanc, E Dewailly, D Prud'Homme, R Lavoie, S Allaire, P Levallois
Journal: Environmental Health Perspectives (1994)

Chloroform is a known contaminant of chlorinated drinking water and of swim- mn l water disinfected with chorine or one of its Few d sing te rtance of dermal d i aain exposure routes to the chloroform body bur- den resulting from do c and rion- al use of chlorinated water.In our experi-
Analysis of HBsAg levels, HBsAg isoforms, HBsAg immune complexes, HBV pregenomic RNA and HBcrAg dynamics during and after NAP-based combination therapy in the REP 301-LTF and REP 401 studies
Authors: Michel Bazinet, Mark Anderson, Victor Pantea, Gheorghe Placinta, Iurie Moscalu, Valentin Cebotarescu, Lilia Cojuhari, Pavlina Jimbei, Liviu Iarovoi, Valentina Smesnoi, Tatiana Musteata, Alina Jucov, Jeff Gersch, Vera Holzmayer, Mary Kuhns, Gavin Cloherty, Andrew Vaillant
Journal: Journal of Hepatology (2020)
Modulation of Bronchial Epithelial Cell Barrier Function by in vitro Ozone Exposure
Authors: Xiao-Ying Yu, Nobuyoshi Takahashi, Thomas L. Croxton, Ernst W. Spannhake
Journal: Environmental Health Perspectives (1994)

The epithelial cells lining the small, peripheral airways function as important targets for the action of inspired ozone. Loss of epithelial barrier integrity in these regions is a common element in ozone-induced airway inflammation. To investigate the direct effect of ozone on epithelial barrier function, canine bronchial epithelial (CBE) cells grown with an air interface were exposed for 3 hr to 0.2, 0.5, or 0.8 ppm ozone or to air. Mannitol flux, used as an index of paracellular permeability, increased above air controls by 461%, 774%, and 1172% at the three ozone concentrations, respectively. Transcellular electrical resistance exhibited a dose-related decrease. The immediate effect of 0.8 ppm ozone on permeability was significantly inhibited by preincubation for 48 hr in the presence of 1 ng/ml vitamin E (33%) or 1 microM vitamin A (34%). Responses to 0.5 ppm or 0.8 ppm were inhibited by pretreatment of the cells with 0.1 microM of the actin polymerizing agent phalloidin (34% and 25% inhibition, respectively). The increases in permeability induced by 0.2 and 0.5 ppm ozone were attenuated by 54% and 22%, respectively, at 18 hr after exposure, whereas that to 0.8 ppm was further enhanced by 42% at this time. The effects of ozone are modulated by the availability of antioxidants to the cells and appear to be associated with cytoskeletal dysfunction in CBE cells. The data are consistent with a loss of barrier function linked to a direct oxidative effect of ozone on individual CBE cells and indicate that the reversible or progressive nature of this effect is dose dependent.
Complementary roles of IRS-1 and IRS-2 in the hepatic regulation of metabolism
Authors: Cullen M. Taniguchi, Kohjiro Ueki, C. Ronald Kahn
Journal: Journal of Clinical Investigation (2005)

Due to an error in manuscript preparation, an incorrect shRNA sequence for IRS2 was published.The correct hairpin sequence is a 19-nt stretch beginning from nt 703 of the published IRS2 cDNA sequence (XM_357863).The oligonucleotides cloned into the U6 construct for the IRS2U6 adenovirus are as follows: tcgagGTGACGCTGCAGCTTATGAttcaagagaTCATAAGCTGCAGCGTCACttttt (forward) and ctagAAAAAGTGACGCTGCAGCTTATGAtctcttgaaTCATAAGCTGCAGCGTCACc (reverse).In addition, the shRNA cassettes were cloned into the adenoviral cosmid pAxcwit, which lacks a promoter, and not the cosmid pAxCAwtit, as published..
Combination of a polyamine-free oral nutritional supplement (ONS) with docetaxel in castrate-resistant prostate cancer (CRPC) patients (pts): A phase II trial.
Authors: Xavier Artignan, Laurent Miglianico, Dominique Bligny, Christine Abraham, Jacques Philippe Moulinoux, Bernard Cipolla
Journal: Journal of Clinical Oncology (2012)

67 Background: Polyamines (PA) are essential for cancer cell growth. Reducing exogenous PA (foods + gut flora) and blocking PA synthesis, reduces tumour growth and potentializes chemotherapy in rodent tumour models. We have developed a PA “free” ONS, which inhibits tumour growth by 40% in pre-clinical models and assessed its tolerance with docetaxel in CRPC pts. Methods: 30 pts, 71 ± 7 years, with metastatic CRPC, median PSA: 95 ng/ml, were assessed for tolerance, quality of life (QLQ C-30 questionnaire), W.H.O. performance status (P.S.), pain scores and prostate specific antigen (PSA) response. 90% pts were painful. 75% pts had opiate or morphinic analgesics at day 0 (D0). Median pain score is 5 (0 to 10 scale). The PA free ONS was given as sole diet (6 cans a day) for 14 days then progressively reduced and given with low PA containing foods. Docetaxel administration started on day 21 for 6, 75 mg/m 2 injections, every three weeks with prednisone. Nutrialys Medical Nutrition, France, provided the PA free ONS. Results: 27 pts were evaluated for the PA ONS free phase. 18 pts completed the trial at scheduled dates and docetaxel doses. 9 pts did not complete the trial: disease progression (n=4), initial thrombocytemia (n=2), 2 deaths and 1 GI intolerance PA free ONS stage: No specific toxicity was recorded. Quality of life (p=0,03), pain (p=0,03) and anorexia (p=0,01) are improved at day 14. 1 pt had a &gt; 50 % PSA decrease. PA free ONS + docetaxel stage: grade 1 or 2 nausea, vomiting or diarrhoea are observed in less than 35 % pts with no onycholysis or neuropathy. Body weight and biological parameters are preserved except for two grade 4 neutropenias. P.S., pain scores and anorexia are improved. 50% pts reduced their analgesic consumption by 50%. 13 pts (46 % of the whole population, 70% pts who completed the trial) had an &gt; 50% PSA decrease. Conclusions: The PA free ONS is well tolerated during the neo-adjuvant phase with quality of life and pain improvements. The docetaxel PA free ONS combination tolerance is excellent with improved P.S., pain score and analgesic consumption. AE during chemotherapy are minimal. PSA responses are observed in a significant proportion of treated patients.
Author's Reply
Authors: Meir Stampfer
Journal: PLoS Medicine (2005)

Covering 60 years of research without mentioning a paper that highlights fl aws in the literature, in a review, should negate any conclusion.In the Cochrane review by Douglas et al. [1], which is referenced in the Best Practice article by Douglas and Hemilä [2], there was no mention of the revealing paper published last year by Padayatty et al. [3], which shows that three-times greater blood concentration can be achieved with an oral dose of vitamin C than previously thought possible.Since viruses increase the demand for ascorbic acid, the oral doses used in the reviewed studies appear trivial, and would not be expected to produce any positive effect.Compare human oral dose studies to what animals synthesize throughout the day.It is obvious that a single dose of a watersoluble vitamin, regardless of the number of milligrams consumed, will not elevate blood plasma levels enough to produce a preventive or therapeutic effect.
Surgical Treatment Of Chronic Pulmonary Embolism
Authors: H. Lyerly
Journal: Annual Review of Medicine (1991)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease 2019 (COVID-19), emerged in China in December 2019 and quickly spread around the globe, killing more than 4 million people and causing a severe economic crisis. ...Read More
Outbreak ofVibrio parahaemolyticusInfection Associated With Eating Raw Oysters and Clams Harvested From Long Island Sound—Connecticut, New Jersey, and New York, 1998
Journal: JAMA (1999)

EACH YEAR, CDC'S ADVISORY COMMITtee on Immunization Practices (ACIP) reviews the recommended childhood immunization schedule to ensure it remains current with changes in manufacturers' vaccine formulations, revised recommendations for the use of licensed vaccines, and recommendations for newly licensed vaccines.This report presents the recommended childhood immunization schedule for 1999 (Figure 1) and explains the changes that have occurred since January 1998.Since the publication of the recommended childhood immunization schedule in January 1998, 1 the ACIP, the American Academy of Family Physicians (AAFP), and the American Academy of Pediatrics (AAP) have narrowed the recommended options for the use of poliovirus vaccine and have endorsed the use of the newly licensed oral, tetravalent rotavirus vaccine.In addition, recommendations were revised or clarified for the use of hepatitis B vaccine in infants born to hepatitis B surface antigen (HBsAg)-negative mothers, the use of diphtheria and tetanus toxoids and acellular pertussis vaccine (DTaP), and the use of Haemophilus influenzae type b (Hib) conjugate and DTaP combination vaccines for infants aged 2, 4, and 6 months.Detailed recommendations for the use of vaccines are available from the manufacturers' package inserts, ACIP statements on specific vaccines, and the 1997 Red Book. 2 ACIP statements for each recommended childhood vaccine may be viewed, downloaded, and printed at CDC's National Immunization Program World-Wide Web site, http:// www.cdc.gov/nip.