tbuckley/cabot-search huggingface dataset:
Abstract 3013: Role of prostanoid signaling in lung cancer
Authors: Pavankumar Pamarthi, Rajkumar Savai, Soni Savai Pullamsetti, Werner Seeger, Friedrich Grimminger, Ralph Schermuly
Journal: Cancer Research (2012)

Abstract RATIONALE: An increasingly large body of evidence indicates that PGE2 promotes tumor growth by stimulating EP4 receptor signalling with subsequent enhancement of cellular proliferation, metastasis and suppression of immune responses. However, the role of other EP receptors is not known. OBJECTIVE: We hypothesized that prostanoid receptors other than the EP4 receptor are involved in progression of Lung cancer. METHODS: We analyzed the expression profile of EP receptors in lung adenocarcinoma cell lines A549 and H1299 by using Real Time PCR, western blotting and immunofluorescence. All four EP receptors are getting expressed in both the cell lines. Both L-161982 (EP4 receptor specific antagonist) and SC-51322 (EP1 receptor specific antagonist) inhibited proliferation of both cell lines as assessed by thymidine incorporation assay. EP2 and EP3 receptors have not shown inhibitory affects in proliferation assays. SC-51322 has not decreased cAMP levels in A549 and decreased intracellular calcium levels. SC-51322 has inhibited pERK levels as shown in the western blots. In addition, SC-51322 inhibited migration of A549 cells in transwell migration assay. CONCLUSION: We conclude that EP1 receptor may play a role in lung cancer progression and metastasis. Finding out downstream molecules to EP1 receptor will give us a better understanding of this pathway in lung cancer and can provide therapeutic opportunities. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3013. doi:1538-7445.AM2012-3013
Institutional Review Board
Authors: Robert J. Levine
Journal: JAMA (1980)

<h3>To the Editor.—</h3> I read with considerable interest the announcement of the conference presented on March 27 and 28, 1980, by Public Responsibility in Medicine and Research (PRIM&amp;R) (242:527, 1980). This announcement stated that Experts in the fields of research, regulation, industry, bioethics, and the administration of research will participate in small group discussions, topical workshops, and plenary sessions covering the roles, rights, and responsibilities of government, the researcher, the<i>IRB: A Review of Human Subjects Research</i>, and the subject. As editor of<i>IRB: A Review of Human Subjects Research</i>, I should have been most pleased if this statement were correct. However, the third topic of discussion actually was the Institutional Review Board, commonly abbreviated IRB. For those readers who are unfamiliar with this term, this is the generic name assigned by Congress in 1974 to committees that review proposals to do research involving human subjects. These committees are charged
Skin Diving
Authors: Donald E. Butterfield, Joel D. Mack, Guido Majno
Journal: New England Journal of Medicine (1963)

Physiopathology of Scuba DivingThe physiopathology of high pressures is certainly weird. A diver has to face problems of different kinds upon descent, in depth, on returning to and on the surface.During Descent While descending, the diver experiences a pressure on the ears. By swallowing, or by similar movements, he must open his eustachian tubes and allow compressed air from his pharynx to enter the middle ear. If he cannot accomplish this correcting maneuver (which is difficult for many people) he will simply have to give up the dive.In Depth In depth there are (among others) pharmacologic . . .
Checkpoint inhibitors in combination with chemotherapy for first-line treatment of advanced non-small cell lung cancer: A systematic review and meta-analysis of randomized controlled trials (RCTs).
Authors: Aung Tun, Wai Lin Thein, Aymen Elfiky, James Gasperino, Elizabeth Guevara
Journal: Journal of Clinical Oncology (2019)

117 Background: Non-small cell lung cancer (NSCLC) accounts for ~85% of lung cancers among which the metastatic disease represents ~ 57%, and long-term prognosis remains poor. Combined chemo-immunotherapy can have synergistic anticancer activities through the immunomodulatory impact of checkpoint inhibitors and the immunogenic effect of chemotherapy. Methods: We systematically conducted a comprehensive literature search using PUBMED, EMBASE and SCOPUS databases through October 1, 2018. RCTs of first-line chemotherapy +/- immunotherapy in patients with advanced NSCLC were incorporated in the analysis. A generic inverse variance method was used to calculate the estimated pooled Hazard ratio (HR) for overall survival (OS) and progression-free survival (PFS). The mantel-haenszel method was used to calculate the estimated pooled risk ratio (RR) with 95% confidence interval (CI) for pooled overall response rate (ORR), all-grade adverse events (AEs), and high-grade AEs (≥ grade 3). Heterogeneity was assessed with Cochrane Q-statistic. Random effects were used due to significant heterogeneity among studies. Results: Seven phase 2 &amp; 3 RCTs (Keynote-021,189, 407, IMpower-131, 150, checkmate-227, and Govindan et al) including 3785 patients with advanced NSCLC were included in the analysis. IMpower 150 trial allowed EGFR or ALK mutated patients. The study arm used standard treatment regimens in combination with ipilimumab, pembrolizumab, atezolizumab, or nivolumab, while control arm used only standard treatment regimens. The pooled HR for PFS was 0.65 (95% CI: 0.56-0.77; P=0.00001), the pooled HR for OS was 0.73 (95% CI: 0.59-0.90; P=0.003), and the pooled RR for ORR was 1.45 (95 CI: 1.17-1.8; P=0.0007). The pooled RRs for all-grade AEs and high-grade AEs were 1.1 (95% CI: 1-1.21; P=0.05) and 1.28 (95% CI: 1.13-1.46; P=0.0001), respectively. Conclusions: Adding immunotherapy to standard regimen significantly improves PFS, OS, and ORR for the first-line treatment of advanced NSCLC. The combined regimen results in a slightly higher risk of high-grade AEs without a significant increase in the risk of all-grade AEs.
Wayside Experiences.
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ambulance services.
Authors: C. L. Hewer
Journal: BMJ (1968)

subheadings, so that all the drugs of similar action were to be found together.The antidepressives are a case in point.Instead of all antidepressives being listed alphabetically, as in MIMS, Medindex classified them into monoamine oxidase inhibitors, thymoleptics, and others.Other useful sections were the paragraphs of indications and safety factors at the beginning of each section, and the index of official and other approved names.I am sure there must be many general practitioners who regret the passing of Medindex as much as I do.
Heart Disease: A Textbook of Cardiovascular Medicine
Authors: Richard J. Jones
Journal: JAMA (1985)

This second edition of Dr Braunwald's book on heart disease is of the same excellent quality as the 1980 edition. It has been improved by several new chapters. The new chapter entitled "Electrocardiography and Vectorcardiography," by Charles Fisch, provides a good review of abnormal patterns of the ECG with the vectorcardiographic equivalents, including ECG patterns related to electrolyte abnormalities, drugs, and specific arrhythmias. There is an interesting review of the mechanism of arrhythmias derived from ECG analysis, including a discussion of exit and entrance block and the gap phenomenon. In view of more recently introduced cardiovascular examinations, a separate chapter "Nuclear Resonance Imaging of the Heart," by A. B. Ratner and G. M. Pohost, has been added. D. P. Zipes presents a new 42-page chapter on "The Genesis of Cardiac Arrhythmias: Electrophysiological Considerations." In addition to reviewing the basic anatomy and electrophysiological principles of the cardiac conduction system, it offers
ACCIDENTAL INJURIES TO THE PROSTATE GLAND.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Radiation Retinopathy
Authors: James L. Kinyoun
Journal: JAMA (1987)

<h3>To the Editor.—</h3> The many reported treatments for Graves' ophthalmopathy reflect its unknown cause and unpredictable course. We are concerned that a recent Letter to the Editor published in<i>JAMA</i><sup>1</sup>does not accurately state the effectiveness and risk of radiation treatment of this disease. Drs Gliedman and Steinfeld state that it is very unlikely that a radiation dose used to treat Graves' ophthalmopathy would be sufficient to cause radiation retinopathy. These authors failed to reference a prior report of four other patients who developed radiation retinopathy following orbital irradiation for Graves' ophthalmopathy.<sup>2</sup>Although the radiation retinopathy in three of those four patients was probably due to a total dosage exceeding the reported 20 Gy (2000 rad), the cause of this complication in the fourth patient remains unknown. We are now aware of a fifth patient who also developed radiation retinopathy following 20 Gy (2000 rad) of external beam
Clarification.
Authors: A G Meek
Journal: Journal of Clinical Oncology (1990)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1990.8.1.184 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 2295910 Clarification. A G MeekxA G MeekSearch for articles by this author https://doi.org/10.1200/JCO.1990.8.1.184 PDF "Clarification.." Journal of Clinical Oncology, 8(1), p. 184© 1990 by American Society of Clinical Oncology
SIX–MONTH INTRAVASCULAR ULTRASOUND ANALYSIS OF THE DESOLVE FIM TRIAL WITH A NOVEL PLLA–BASED FULLY BIODEGRADABLE DRUG–ELUTING SCAFFOLD
Authors: José de Ribamar Costa, Stefan Verheye, Mark Webster, Jim Stewart, Alexadre Abizaid, Ricardo Costa, Rodolfo Staico, Daniel Chamie, Vinayak Bhat, Lynn Morrison, Sara Toyloy, John Ormiston, ZNA Middehein
Journal: Journal of the American College of Cardiology (2013)
Explaining Variations in Hospital Death Rates
Authors: Gregory Binns
Journal: JAMA (1991)

<h3>To the Editor. —</h3> If one takes the data presented by Park et al<sup>1</sup>at face value, very important considerations for quality improvement activities were omitted in the abstract and "Comment" sections, even though these conclusions are readily apparent in the data. A cursory reading will cause readers to miss the crucial implications of this research. Random binomial variation, a medical record—based severity of illness adjustment, and a detailed process measure of quality could not explain the substantial difference between expected and observed deaths at hospitals with high death rates. There was an unexplained excess over the average hospital after adjustment in the hospitals with high death rates of 37% of inpatient deaths and 5% of deaths 30 days postadmission for patients with congestive heart failure and 14% of inpatient deaths and 9% of deaths 30 days postadmission for patients with acute myocardial infarction. Obviously, something other than the
Medical Manual of Chemical Warfare, 1940 [including] "An Atlas of Gas Poisoning."
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Erratum
Journal: BMJ (1914)

2. Official Handbook of Duties of a -"11Ship Surgeon1."-TheMarine Department should print and circulate a pamphlet stating the duties of a medical officer of a ship as to sanitary powers, inspection of food, clothing and lodgement of the crew or passengers, a prrcis of quarantine regulationis and of the tests for jhysica1 efficiency of officers and men of the merchant service.3. Examtin-ation, in?Details of above Handbook.-The
AIDS policy into the 1990s
Authors: R. Sherer
Journal: JAMA (1990)

A grim metaphor heard at the First International AIDS Conference in Atlanta in 1985 was that the acquired immunodeficiency syndrome (AIDS) was "a nightmare from which one can never awaken." It was actually two nightmares, in parallel: the syndromes of human immunodeficiency virus (HIV) disease and their attendant suffering and mortality, and a second epidemic of fear and discrimination. The power of those fears to disrupt lives was most vividly demonstrated by the experience of a family with three hemophiliac children. When the parents voluntarily disclosed the HIV antibody status of their sons, they were barred from the local public school and their church, socially ostracized, and finally driven from town when their home was burned (<i>New York Times</i>. August 31, 1987:1). Similar instances of violence and hatred perpetuated by irrational fears have been experienced by homosexual men, drug users, and others affected or perceived to be at risk. For
Cardiac surgery
Authors: R. S. Iyer, J. P. Jacobs, M. J. Elliott, M. R. de Leval, J. Stark, J. Thul, F. Wippermann, R. Huth, I. Michel-Behnke, F. X. Schmid, D. Schranz, N. R. Patel, C. J. L. Newth, E. L. I. M. Duval, A. Kavelaars, L. Veenhuizen, A. J. van Vught, H. J. C. M. van de Wal, C. J. Heijnen, Ina Michel-Behnke, Claudia Schnittker, F. X. Schmid, C. F. Wippermann, J. Thul, R. G. Huth, D. Schranz, P. Vázquez, J. López-Herce, A. Carrillo, M. Sánchez, R. Moral, A. Bustinza, J. Vassallo, C. Cernadas, A. Saporiti, L. Landry, G. Rivello, D. Buamsha, D. Rufach, R. Magliola, A. Alcaraz, L. Sancho, L. Manzano, F. Esquivel, A. Carrilo, M. Alvarez-Mon, F. Esquivel, A. Sánchez-Galindo
Journal: Intensive Care Medicine (1996)
Epilepsia Erratica
Authors: D. Mackinder
Journal: BMJ (1866)

as to the amount of valvular change-the presence or absence of the second sound in the nick in aorti( -regurgitation.At the base of the heai, a seconc sound will be heard, whatever the condition of the aortic valves may be, produced by the'pulmonar3 valve; but if, with a diastolic aortic nurmur, this sound is heard in the great vessels of the neck, it may be concluded that the aortic valves still act, and that the regurgitation is probably incon-
Another Census
Journal: BMJ (1963)

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Massachusetts Medical Society
Authors: John Figgis Jewett
Journal: New England Journal of Medicine (1955)

COMMITTEE ON MATERNAL WELFAREPulmonary Atelectasis and EmphysemaA twenty-seven-year-old gravida IV, para III, died during cesarean section, thirteen days before her estimated date of confinement.Scheduled for her fourth section, she received at 7:00 a.m. 0.2 gm. of Seconal by mouth. An hour later a single spinal injection was given consisting of 14 mg. of Pontocaine with 1 per cent dextrose to a volume of 2.1 cc. Immediately before the injection 2 mg. of Neo-Synephrine was given intramuscularly. The blood pressure remained constant at 124 systolic, 90 diastolic, the patient being conscious and rational.Shortly afterward the operation was . . .
Field Water Disinfection
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CONSTITUTIONAL POWER OF CITIES TO PUNISH ADULTERATION OF MILK.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bacterial resistance in the community.
Authors: G Egdell, P Fisher, H Sutherland, R Dinwiddie, G Russell, D Fahmy, A Turnbull, D Turnbull
Journal: BMJ (1973)

found in practice to be of equal value and also safe in the diagnosis of two small series of mute psychiatric inpatients.2 "Poor-risk" patients, especially those sus- ceptible to respiratory or cardiovascular depression, will need extra care, but even then intravenous diazepam and lorazepam have been shown to be less hazardous than intravenous barbiturates.4Care is also necessary with epileptics receiving parenteral barbiturates or paraldehyde,5 patients taking Mandrax6 and during curarization.7Apnoea with diazepam alone has been reported in an 80-year-old patient.8Such risks must be balanced against the importance of diagnosing and treating the underlying cause of the mutism.-Iam, etc., H.
Radiations and Living Cells: An Introduction to Radiation Biology, in Which the Action of Penetrating Radiations on the Living Cell is Described, with Special Reference to the Effect on Cell Division in Human Tissues
Journal: JAMA (1953)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal