tbuckley/cabot-search huggingface dataset:
Mortality rates after 10.5 years for participants in the Multiple Risk Factor Intervention Trial. Findings related to a priori hypotheses of the trial. The Multiple Risk Factor Intervention Trial Research Group
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 1726: Structure-function analysis of retinoblastoma tumor suppressor protein in human cone precursors
Authors: Sijia Wang, Brendan Grubbs, Matthew Thornton, David Cobrinik
Journal: Cancer Research (2019)

Abstract Background: The retinoblastoma protein, pRB, is a key cell cycle governor that is functionally impaired in most cancers, but its mechanism of suppressing tumorigenesis in a tumor cell-of-origin has not been characterized. This study aims to define pRB structural features and corresponding cellular functions that suppress cone precursor (CP) proliferation, likely the first step in retinoblastomagenesis. Method: Intact human fetal retinae were co-transduced with lentiviruses to knockdown endogenous pRB and ectopically express wild type or structure-based substitution mutant pRBs. The ectopically expressed pRB mutants had selectively impaired interactions with E2F transactivation domains (ΔG), with the E2F1 “marked box” domain (ΔS), or with the LxCxE protein interaction motif (ΔL). At day 12-75 post-infection, transduced retinae were analyzed by quantitative immunofluorescence staining of Ki67/EdU, pRB and CP marker L/M-opsin. Results: In intact retina, pRB knockdown induced cell cycle re-entry of L/M-opsin+ postmitotic cone precursors, whereas those reconstituted with wild type pRB did not express Ki67 indicative of a block to cell cycle entry. Unexpectedly, all three mutants (pRB-ΔG, -ΔL, and -ΔS) were able to block cell cycle re-entry when expressed at the high-normal range the of endogenous pRB. However, at the low-normal expression level, ectopic wild type but not mutant pRBs suppressed proliferation. Conclusion: All three surface targeted mutants (pRB-ΔG, ΔL, and ΔS) retain partial ability to suppress cone precursor cell cycle entry. This may be attributed to the presence of multiple independent cell cycle inhibitory functions. These findings suggest that pRB-mediated regulation of E2F-responsive cell cycle genes, interactions with LxCxE motif-containing proteins, and EZH2 mediated repression of repetitive elements are individually dispensable for suppressing aberrant cone precursor proliferation. Citation Format: Sijia Wang, Brendan Grubbs, Matthew Thornton, David Cobrinik. Structure-function analysis of retinoblastoma tumor suppressor protein in human cone precursors [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1726.
New Epilepsy Drug Approved for Adults and Children
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Microbiology in Multiple Sclerosis: Evaluation of Ichelson's Organism
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Preventive control of hypertension
Authors: S. K. Robinson
Journal: JAMA (1970)

<h3>To the Editor.—</h3> In response to the query on how to manage a 36-year-old man who since age 18 had had a blood pressure of 140/90 to 150/100 mm/Hg (<b>210:</b>142, 1969), Dr. A.P. Shapiro replied, his hypertension has been nonprogressive "and needs a minimum of therapy. Most authorities would agree that evidence is lacking to indicate clearly that trying to bring his blood pressure to lower levels by hypertensive drugs would improve his prognosis for longevity or for prevention of atherosclerotic cardiovascular complications." He mentions the adverse side effects of long-term therapy with the thiazides. There is evidence that early treatment is advisable. According to figures by the Metropolitan Life Insurance Co., 140 systolic and 95 diastolic mm/Hg increases mortality 2.5 times over standard risk in a person of this age; for 150 systolic and 100 diastolic mm Hg, it increases 5 times (<i>Med World News</i><b>4:</b>50, 1963).
Marijuana
Journal: JAMA (1981)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
OSWALD SCHMIEDEBERG (1838-1921) EXPERIMENTAL PHARMACOLOGIST
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Epidemiology in Occupational Disease and Injury
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Skin: A Clinicopathologic Treatise.
Journal: Annals of Internal Medicine (1967)

tively helped to restore morbid anatomy to its rightful position as a basic medical science.The early years of Turnbull's directorship were not easy : he had to fight for what he knew to be essential against apathy and the die-hards intolerant of change.His ultimate achieve- ment was recognized beyond the confines of academic pathology, and in 1929 he received the F.R.C.P., followed by the F.R.
Congenital arteriovenous fistula causing congestive heart failure in the newborn
Authors: D. E. Murray
Journal: JAMA (1969)

A large arteriovenous fistula, involving the epigastric arteries and the umbilical vein and associated with congestive heart failure, occurred in a newborn infant. An aortogram was made through the umbilical artery. Then the involved vessels were ligated and excised. The cardiomegaly rapidly decreased in size, and the infant recovered. The signs of these fistulas include heart failure, widened pulse pressure, bruit, and thrill.
Saunders' Question Compends No. 7. Essentials of Materia Medica, Therapeutics, and Prescription Writing.
Journal: JAMA (1889)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bio-Priming Effect Of Three Phosphate Solubilizing Fungi On Seed Germination And Seedling Development Of Faba Bean (Vicia Faba)
Authors: Birhanu Gizaw
Journal: Clinical Cardiology and Cardiovascular Interventions (2019)

Germination and seedling establishment are critical stages in the plant life cycle. The aim of this study was to evaluate the effect of phosphate solubilizing fungi on seed germination and seedling growth of Faba bean. Phosphorus is an essential macronutrient next to nitrogen required by plant for vital biosynthesis. Factorial experiment based a completely randomized block design with three replications were used. This experiment had two factors, the first factor with one level of bean cultivar. In the second factor, three levels of phosphate solubilizer fungi were applied as treatments. Single inoculation of each strain was done. The results revealed that seed treated withTrichosporon beigelii B, C. albidus var aurius, Phichia norvegensis and Control showed 780.43, 749.93, 618.23, 500.73 seedling vigor index respectively and improved germination rates up to 91%. The highest mean growth of plumule length (5.6 cm) and radicle length (3.42) within 15 days growth recorded by Trichosporon beigelii B, and C.albidus var aurius respectively. The results of this study suggest that T. begili and C. albidus var aurius have the potential to increase the growth and development of plumul size, radicle length, and fresh biomass of Faba bean seed. Bio-priming is a promising technique for vital application of using beneficial microbes to promote seed germination and seedling development through phytase enzyme production, phyto hormone production, phosphate solubilization and other plant growth promoting properties as well as bio control activities.
The Laryngoscope and its Clinical Application
Authors: T. J. Walker
Journal: BMJ (1863)

slhe had a very severe sore-throat, which had been lanced and burnt with caustic by Mr. Knowles, of Farnhan-, under whose care she remained for five mnonths.In December 1862, beiing thejn extremely depressed and weaik, and having scarcely recovered from her bad throat, she lost lher voice; and since then she had never been able to speak a word out loud.MIr.Knowles recom- mended change of air, and so also did Dr. Cobb (formerly of the London Hospital).After a fortnig,lit's i esidence i London, the patient applied at the Dispenisary in the condition describe(l.On making a laryngoscopic examination, the approx- imative actiun of the vocal cords was seen to) be very feeble; otherwise, the larynx was perfectly healthy.August 25th.I galvanised the vocal cords, and the voice immediately returned.It was weak at first, but soon became full and strong.I only repeated the gal- vanism onice (on the 27th); but the voice was really re- stored by the first application.CASE XIV.Aphoniia of Five M1onths' standing cured by
Error in Funding/Support
Journal: JAMA Oncology (2021)

Nilanjan Ghosh, MD, PhD; Sairah Ahmed, MD; Kwang Woo Ahn, PhD; Manoj Khanal, MS; Carlos Litovich, MPH; Mahmoud Aljurf, MD, MPH; Vera Ulrike Bacher, MD, MHBA; Christopher Bredeson, MD; Narendranath Epperla, MD; Nosha Farhadfar, MD; César O. Freytes, MD; Siddhartha Ganguly, MD; Bradley Haverkos, MD; David Inwards, MD; Rammurti T. Kamble, MD; Hillard M. Lazarus, MD; Lazaros Lekakis, MD; Hemant S. Murthy, MD; Taiga Nishihori, MD; Praveen Ramakrishnan, MD; David A. Rizzieri, MD; Jean A. Yared, MD; Mohamed A. Kharfan-Dabaja, MD, MBA; Anna Sureda, MD, PhD; Mehdi Hamadani, MD
Adrenal Suppression Caused by 16-Methylene-Prednisolone: Demonstration by Gas-Chromatography
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Response
Authors: W. H. CLARK
Journal: JNCI Journal of the National Cancer Institute (1990)

Journal Article Response Get access WALLACE H. CLARK, JR. WALLACE H. CLARK, JR. 217 Clinical Research Bldg., Department of Dermatology, University of Pennsylvania, 422 Curie Blvd,Philadelphia, PA 19104–6013 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 82, Issue 7, 4 April 1990, Page 627, https://doi.org/10.1093/jnci/82.7.627 Published: 04 April 1990
MADRID
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The primacy of insulin
Authors: R. H. Unger
Journal: JAMA (1977)

<h3>In Reply.—</h3> The issues raised by Christopherson focus attention on the use of two types of incidence rates: ageadjusted and age-specific. His observation regarding the California rateswould be essentially correct if the population of interest were the total female population. Proudfit's article, however, is directed specifically to the assessment of measures of risk of endometrial cancer among postmenopausal women. Accordingly, she accurately cited data from the California Tumor Registry for white women, aged 50 to 74 years. The Table illustrates the effect of using (age-adjusted) rates for total white women and of using (age-specific) rates for only the postmenopausal age group cited by Proudfit. While the annual age-adjusted rates are more comparable to those cited by Christopherson, the apparent increase in incidence over the period of observation is substantially diminished. By contrast, the proportional increase in the older age group is much greater, reflecting the fact that a highly
Ainhum
Authors: Mauray Tye
Journal: New England Journal of Medicine (1946)

AINHUM, or spontaneous dactylolysis, which occurs predominately in male Negroes, has been described as a distinct disease by some authors and as a symptom by others. At the digitoplantar fold there appears a constricting ring of fibrous tissue, which deepens and finally strangulates the underlying structures, producing spontaneous amputation.Weinstein1 gives Messum2 credit for the original description of the condition in 1821, but most authors give it to Clark,3 who in 1860 described a lesion considered as a sequela to yaws in natives of the Gold Coast. The name of the disease and the first adequate description of it were . . .
Bureau of Investigation
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal