tbuckley/cabot-search huggingface dataset:
Clinical Pulmonary Physiology
Authors: Edward A. Gaensler
Journal: New England Journal of Medicine (1955)

BronchospirometryBronchospirometry, the simultaneous and separate recording of ventilation and gas exchange of the two lungs, was first performed in man with the double bronchoscope of Jacobaeus and his associates.207 A number of clinically informative results were obtained,129 but the procedure was not generally accepted until pliable, double-lumen catheters simplified the examination and made it more agreeable to patients.208 , 209 These rubber catheters have separate tubes for the two lungs within a single sheath. The airways are isolated from each other and from the atmosphere by inflatable rubber cuffs. Intubation is accomplished by indirect laryngoscopy under topical anesthesia; proper placement is . . .
European Perspectives
Journal: Circulation (2012)

Foundation supports sci- entists primarily based in the Netherlands to carry out research that contributes to the development of new drugs.Master's and PhD students can apply for a fellowship of around €4000 to work abroad or €2500 to stay in the Netherlands.Up to 8 fellowships are awarded each year.Candidates are judged on the originality and quality of the research, which should directly or indirectly focus on the development of new drugs
Illinois State Board of Health.
Authors: J. W. Scott
Journal: JAMA (1895)

gans, followed, soon or late, by more or less pronounced chill, febrile reaction and diaphoresis, the physiologic and pathologic expressions of thermometric and hygrométrie environment.A simple and rational prophylaxis will readily suggest itself to those who are not wedded to the old ruts, and who do not go " round Robin Hood's barn," to find causation.If, instead of wooing the cool and chilling air of night in the garb of fashion, or going to sleep in the damp clothes worn during the day, and half covered, those living in such localities would pay due regard to ordinary hygienic laws, and take a friction bath, damp or dry, as night approaches, put on dry warm clothing, and sleep be¬ tween flannel blankets, they may laugh to scorn both the marsh poison and pathogenic germs of even the lagoons of Hindostán, or the swamps of Louisiana.W. L. Schenck, M.D." Audi Tertiam Partem."San Francisco, Cal.,
Incorrect Figure.
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Parasitic Animals
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medicolegal: Dr Gee v the BBC and two doctors
Journal: BMJ (1984)

Uk' I Liverpool is an extreme case but it illustrates many of the things that went wrong in the '60s and '70s.Phases II and III were started in 1968 and due for completion in 1974 at a cost of £11 8m.The contractor got into financial difficulties early on and the site was dogged by strikes and pay claims.In 1975 the contractor went out of business and first one then another contractor was brought in to finish it.There were extra costs for remedying defects, for increasing the content of the hospital, and for bringing it up to current regulations on energy use, the housing of animals, and-most important-fire safety.In 1976 the DHSS told the Public Accounts Committee that the final building, still not complete, would cost £54 19m much of it due to inflation.The hospital consisted of a two
A specific miRNA signature correlates with complete pathological response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer.
Authors: G. Della Vittoria Scarpati, C. Carlomagno, S. Marchini, P. Ubezio, F. Falcetta, M. D'Incalci, S. De Placido, F. Sabbatino, C. Fusciello, S. Pepe
Journal: Journal of Clinical Oncology (2011)

3610 Background: MicroRNAs (miRNAs) are small, non-coding RNA molecules which are emerging as key regulators of numerous cellular processes. MiRNAs may be abnormally down-regulated or up-regulated in colo-rectal cancer. Specific miRNA patterns may be associated to particular behaviour of tumours and could be used as a predictive factor of response to treatments. We used microarrays and RT-PCR to profile miRNA expression patterns in patients (pts) with locally advanced rectal cancer treated with neoadjuvant chemo-radiotherapy followed by surgery, in order to identify a specific “signature” correlating with response rate. Methods: 39 pts with locally advanced rectal cancer (cT3-4/N+) were treated with capecitabine-oxaliplatin and pelvic conformal radiotherapy (45 cGy) followed by surgery (after 6-8 weeks). Pathologic response was scored according to the tumor regression grade (TRG) scale. MiRNA expression profile was analysed by microarray on fresh frozen biopsies obtained before treatment start and confirmed by RT-PCR. The correlation between miRNA expression profile and the TRG coded as TRG1 (pathologic Complete Response-pCR) versus TRG >1 (no pCR) was assessed by the χ(2) test and logistic regression analysis. Results: 9/39 pts experienced a pCR and in 7/9 pts the fluorescence levels of 12 miRNAs (has-miR-765, has-miR-1183, hsv-miR-H1, hsa-miR-483-5p, has-miR-622, hsa-miR-125a-3p, has-miR1224-5p, has-miR-188-5p, has-miR-1471, has-miR-671-5p, has-miR1909STAR, has-miR-630), were significantly higher with respect to TRG>1 patients (all p<0.005); moreover, these 12 miRNAs are strongly linked each other (sensitivity of 78% and a specificity of 80%). Conclusions: A specific cluster of 12 miRNAs is strongly associated with therapeutic outcome and may represent a specific “signature” of response. This information may be utilized as a novel biomarker to predict response to treatments.
Arzneimittel-Synthese
Journal: JAMA (1953)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THOMAS LAYCOCK (1812-1876) MENTAL PHYSIOLOGIST MEDICAL PSYCHOLOGIST
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Consultants' Superannuation
Authors: P. Plumley
Journal: BMJ (1973)

bound iodine, total serum thyroxine, or tri- iodothyronine (T-3) uptake alone.In a study similar to that of Dr. Evered and his colleagues various thyroid function tests (total serum tihyroxine, free thyroxine, free thyroxine fraction, thyroxine: thyroxinebinding globulin (TBG) ratio and 24-hour uptake of 131I) were compared in 43 patients with mild or overt primary hypothyroidism.4The results are shown in the figure.The broken line indicates the lower limit of the normal range for each test (taken as 2 S.D. Serum thyroxine (nqgml) 3 o 10 20 30 40 s;o 60 Free thyroxine fraction 5(as %nra tnad 0 40 50 60 70 s 90 , Thyroxine: TBG ratio (x 00)1JUnJ.
Brucellosis in the United States. Past, present, and future
Authors: R. I. Wise
Journal: JAMA (1980)

The incidence of human brucellosis has declined in the United States since 1947, when 6,321 cases were reported, to 175 cases reported in 1973. A resurgence occurred in 1974 and 1975, when 247 and 328 cases were reported, respectively. This increase followed an increase in incidence of bovine brucellosis as indicated by an increase from 4.3 reactors per 1,000 market cattle in 1971 to 6.8 in 1974. Recurrence occurred in 15 states that had been free of the disease, and increased incidence occurred in other states. A total of 16,401 infected herds were identified in 1975, and 90% of these were in 11 states. Migration of infected cattle occurs through market channels. Effective control of brucellosis leading to local eradication, which could be national in scope, is biologically feasible. Physicians have a responsible role in this eradication. (<i>JAMA</i>244:2318-2322, 1980)
LAPAROTOMY IN THE AMPHITHEATRE.
Journal: JAMA (1890)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Immunotherapy-Immunomodulation
Authors: Roy Patterson
Journal: JAMA (1982)

IMMUNOTHERAPY has been carried out since the days of Pasteur and Jenner (Fig 21-1). Its development constitutes one of the most successful chapters in medical history. The virtual elimination of a wide variety of diseases as the result of antibacterial or antitoxic antibodies is well appreciated. The more recent development of immunization regimens that are specific for viruses, epitomized by the virtual elimination of polio, represents ongoing research of the greatest import to the nation's public health. Although immunizations for bacterial diseases such as pneumococcal pneumonia lapsed with the introduction of penicillin and the other antibiotics, there is a resurgence of interest in this area. Persons whose immune status is compromised, such as patients with sickle cell anemia, respond poorly to pneumococcal infections, even when treated with antibiotics. Field trials suggest that antibodies developed against specific pneumococcal polysaccharides are useful in such persons, and we have just witnessed the marketing
Abstract 318: Jnk3 Regulates Angiogenesis via a Sirtuin1, Creb1 Axis in Peripheral Tissue
Authors: Shashi Kant, Siobhan M Craige, Kai Chen, Michaella M Reif, Kasmir Ramo, Roger J Davis, John F Keaney
Journal: Circulation Research (2017)

Peripheral artery disease (PAD) affects nearly 10 million people in the United States alone, yet patients with clinical manifestations of PAD (e.g. claudication and limb ischemia) have limited and ineffective treatment options. In ischemic tissues, stress kinases, c-Jun N-terminal kinase (JNK), are activated. Here we show that inhibition of the JNK3 isoform, which is most highly expressed in the peripheral nerves, strikingly potentiates angiogenesis and blood flow recovery from mouse hind limb ischemia. JNK3 deficiency leads to increased pro-angiogenetic growth factors such as Vegfa , Pdgfb , Pgf , Hbegf and Tgfb3 in ischemic muscle and cells by repression of the transcription factor Creb1. JNK3 acts through sirtuin 1 (SirT1) to suppress the activity of Creb1. With Sirt1 suppression, as in JNK3 -deficient mice, Creb1 is more active and upregulates pro-angiogenic factors. Together these data suggest that the JNK3/Sirtuin1/Creb1 axis coordinate the vascular remodeling response in peripheral ischemia.
Legionnaires' disease not limited to lungs
Authors: P. Gunby
Journal: JAMA (1980)

Much of the mystery has been stripped from Legionnaires' disease since its startling appearance in 1976, but the emerging clinical picture is no less ominous in several respects. Recent reports indicate that systemic spread from the lungs is more common than previously thought, that there may be more than 71,000 deaths in adults from unrecognized Legionnaires' disease in the United States annually (<i>JAMA</i>1980;243:2311-2313), and that diagnosis remains a challenge. The latest findings on systemic dissemination indicate that<i>Legionella pneumophila</i>spreads from the lungs to other organs in about one of every four patients, especially if there is concurrent disease. This conclusion comes from a retrospective study of 23 fatal cases of Legionnaires' disease conducted by Dennis D. Weisenburger, MD, Charles M. Helms, MD, PhD, and Edward D. Renner, PhD, and presented to the joint St Louis meeting of the College of American Pathologists and the American Society of Clinical
Parallel 12: Clinical and Translational Advances in Complications of Cirrhosis
Authors: Laura Bull, Donglei Hu, Sohela Shah, Luisa Temple, Karla Silva, Scott Huntsman, Jennifer Melgar, Mary Geiser, Ukina Sanford, Juan Ortiz, Richard Lee, Juan Kusanovic, Elad Ziv, Juan Vargas
Journal: Hepatology (2015)
The principles and practice of morning report
Authors: T. A. Parrino
Journal: JAMA (1986)

Morning report is a traditional ritual on academic medical services. At morning report, house staff and faculty review case management and the principles of clinical medicine. To understand better the role and function of morning report and to assess its value for supervision, teaching, and evaluation of clinical knowledge and skills, a survey of academic departments of medicine was conducted. A questionnaire was sent to 124 departments of medicine represented by the membership of the Association of Professors of Medicine. The response rate was 94%. Morning report was important for teaching and was also useful for evaluation of resident performance and quality of clinical care. Some potential problems were identified when the conference is used for peer review and performance evaluation. Morning report stands out as the only large, formal conference generally used for the evaluation of case management and the performance of medical residents. As such, its limitations must be recognized. Recommendations are made for taking advantage of the unique educational opportunities available at morning report. (<i>JAMA</i>1986;256:730-733)
Gomers
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
IRITIS SPONGIOSA.
Authors: ADELINE E. PORTMAN
Journal: JAMA (1898)

Prior to 1870 almost nothing is found giving more than two forms or divisions of iritis, it being classed either as syphilitic or rheumatic, there being only three forms of exudations given in the so-called parenchymatous, namely, serous, plastic and suppurative, the clinical history, cause, treatment and termination being distinct in the type. <h3>Serous.</h3> —Develops slowly; no pain; normal pupil or slightly dilated; little or no injection of vessels and long duration; usually shows punctate deposit on posterior surface of cornea; aqueous humor cloudy; ends without adhesions or serious effects. Treatment expectant, hygienic and constitutional, according to causes found. <h3>Plastic.</h3> —Pain pronounced; onset rapid; pain referred to frontal and other branches of fifth pair, worse at night; circumcorneal injection, photophobia and lachrymation; pupil contracted; iris discolored and engorged, may be nodules upon its surface; exudation of lymph and iritic adhesions follow. Treatment: antiphlogistics, mydriatics and sometimes mercury. <h3>Suppurative.</h3> —Iris very
Dermatology
Authors: E. Dorinda Shelley
Journal: JAMA (1992)

This is the dermatology text I would choose to take with me to a desert island (even though it is very heavy). It makes dermatology exciting in a way unmatched by other current comprehensive derm books. Flipping through the glossy pages uncovers an atlas of exquisite color photographs, many of quarter-page size. With 827 figures, mostly in color, and 131 tables, each page is interesting and inviting. Every physician and physician-to-be, including both newly minted and senior dermatologists, can learn a lot from these pictures, which range from bug bites to lichen sclerosus et atrophicus, and Reiter's disease to minocycline pigmentation. This is the first English edition of a German textbook that has enjoyed three editions (1960, 1969, 1984). Originally designed in accordance with the training requirements of medical students in Germany, it is organized by morphology (eg, pustular diseases) and etiology (eg, ectoparasites and insect bites). It is easy
Periodic Recertification
Authors: John B. Hickam
Journal: JAMA (1970)

Periodic recertification is apparently being considered by a number of specialty boards, but none has so far adopted a program for actually getting it done. About two years ago the Long Range Planning Committee of the American Board of Internal Medicine reported to the board that periodic recertification of its diplomates should be undertaken. The board accepted this recommendation in principle a year ago and has discussed its implementation since then. In pursuing the subject the board members have had some of the feelings of a hunter going into tall grass after a wounded Cape buffalo. Though we have, in fact, been hesitant, we have taken one definite step. We have announced that we will award a qualifying certificate to candidates who have passed our written, or qualifying examination, but that they will be subject to a requirement for renewal of this, or any higher level of certificate subsequently earned, at a date and by a mechanism to be determined by the board in the future. With all the
AN ENVIABLE PRINCIPALITY.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal