tbuckley/cabot-search huggingface dataset:
Physician Travelers
Authors: Marjorie C. Meehan
Journal: JAMA (1972)

P hysicians have long been fond of travel. According to Singer and Underwood, Egyptian doctors traveled widely and attended most of the monarchs of the ancient world. Hippocrates led a wandering life. Galen made long journeys to extend his knowledge. Medieval adventurous spirits journeyed from Christian Europe into Spain to obtain access to Arabic learning. Paracelsus was essentially a wanderer. Later physicians have also traveled, for study, scientific investigation, pleasure, or as medical advisers to military, diplomatic, or exploratory expeditions. Today, doctors attend medical conventions and seminar cruises, or join chartered flights sponsored by medical societies. When they return they usually want to tell their friends about what they have seen, often exhibiting slides of the more spectacular sights. Before the days of photography, many physician travelers wrote books about their trips. Eighteen books written between 1677 and 1887 by physicians who traveled for many different reasons, have now been
The Effects of an Indigenous Muscarinic Drug, Betel Nut (&lt;char aid="99877215" id="ital"&gt;Areca catechu&lt;/char&gt;), on the Symptoms of Schizophrenia: A Longitudinal Study in Palau, Micronesia
Authors: Roger Sullivan
Journal: American Journal of Psychiatry (2007)

Objective: This study tested the findings of a prior study indicating a therapeutic relationship between consumption of betel nut and symptoms of schizophrenia. Method: The subjects were 65 outpatients with diagnoses of schizophrenia or schizoaffective disorder. Symptoms rated with the Positive and Negative Syndrome Scale were compared between high- and low-consumption betel chewers in a repeated-measures design. Movement disorders were assessed with the Abnormal Involuntary Movement Scale and Simpson-Angus Rating Scale. Global health and social functioning were assessed with the Medical Outcomes Study 12-item and 36-item Short-Form Health Surveys, respectively. Results: Male high-consumption betel chewers had significantly milder positive symptoms than low-consumption chewers over 1 year. Betel chewing was not associated with global health, social functioning, or movement disorders. Betel chewing was associated with tobacco use but not with cannabis or alcohol. Conclusions: These findings have clinical significance in betel-chewing regions and broader implications for theory of muscarinic neurophysiology in schizophrenia.
Treatment of patients with metastatic solid tumors with intentionally mismatched lymphocytes activated with rIL-2 in the outpatient setting
Authors: R. Or, A. Ackerstein, S. Morecki, Y. Gelfand, S. Samuel, S. Slavin
Journal: Journal of Clinical Oncology (2004)

2576 Background: Graft vs malignancy (GVM) effects are well established in hematological malignancies with potential clinical application for metastatic solid tumors. We evaluated feasibility immunotherapy using intentionally mismatched lymphocytes in patients with resistant metastases. Methods: 21 patients with metastates, 12 males, 9 females, 1.5 - 74 (median 52) years old participated: breast (7); colon (4); glioblastoma (3); thyroid (1) ovary (1); multiple myeloma (2) and non-Hodgkin's lymphoma (1); melanoma (1), carcinoid (1). To improve efficacy and prolong duration of circulating donor lymphocytes, aiming for self-limited GVM effects, 10/21 patients received fludarabine 25mg/m2/day (x5) and Roferon A 3x106 IU/day (x2). On day 0, lymphocytes from mismatched family members were infused after in vitro activation (rIL-2 6,000 IU/mx4 days). In 5 patients with liver metastasis, lymphocytes were injected into the hepatic artery. Median mononuclear cell dose infused 1.4 (range 2–25.5) x 107/Kg. Starting with cell infusion (day 0), outpatient rIL-2 (6x106 IU/m2 daily) was self-administered 5 days, subcutaneously. Panorex was given in conjunction with cell therapy to 3 patients with metastatic colon cancer aiming for antibody-dependent cell-mediated cytotoxicity. Results: Treatment was well tolerated and no patient required admission. One with colon cancer had PR with transient engraftment of donor cells, showed no evidence of disease no chemotherapy for 16 months. Second patient with metastatic breast cancer developed skin rash compatible with cutaneous GVHD with liver enzyme abnormality. Albeit lack of evidence for chimerism, she had no evidence of progressive disease for 23 months. Two patients with multiple myeloma with no evidence of disease for 57,42 months respectively. The other 17 patients had progressed. Conclusions: Based on our observations in mice and man, adoptive immunotherapy with transient "parking" of mismatched, hence maximally activatable donor lymphocytes, is a feasible and well tolerated clinical tool, potentially useful for controlling minimal residual disease. No significant financial relationships to disclose.
Journal of Reproductive Medicine, Chicago
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE TREATMENT OF PYELITIS IN INFANCY AND CHILDHOOD
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Outpatient Anesthesia
Authors: Max S. Sadove
Journal: JAMA (1979)

This small text edited by Burnell R. Brown, Jr, is based largely on the techniques and activities in outpatient anesthesia in the Ambulatory Surgery Center at Tuscon Medical Center. It deals with the basic concepts and rules of premedication, nitrous relaxants vs volatile anesthesia, regional anesthesia, a checklist of drug interaction in the outpatient, and monitoring. There is also a section on pain management in this ambulatory care unit. The book can be read quickly and easily. It is concise and of practical use. There is little that would be surprising or debatable except for the outpatient peritoneoscopy without an endotracheal tube. In general, it can be recommended to anyone interested in this aspect of anesthesiology.
Author Correction
Journal: Journal of Clinical Oncology (2013)

contained an error.In the first column and fourth row of Table 2, the percentage of patients with high intratumoral macrophage (M⌽) density and positive hepatitis B e antigen (HBeAg) was given as 3%, whereas it should have been 30%.In addition, the percentage of patients with high intratumoral macrophage (M⌽) density and negative hepatitis B e antigen (HBeAg) was given as 97%, whereas it should have been 70%.
Principles in the Treatment of Inflammation
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Asthma in preschool children: prevalence and risk factors
Authors: M M Haby, J K Peat, G B Marks, A J Woolcock, S R Leeder
Journal: Thorax (2001)

BACKGROUND The prevalence of asthma in children has increased in many countries over recent years. To plan effective interventions to reverse this trend we need a better understanding of the risk factors for asthma in early life. This study was undertaken to measure the prevalence of, and risk factors for, asthma in preschool children. METHODS Parents of children aged 3–5 years living in two cities (Lismore, n=383; Wagga Wagga, n=591) in New South Wales, Australia were surveyed by questionnaire to ascertain the presence of asthma and various proposed risk factors for asthma in their children. Recent asthma was defined as ever having been diagnosed with asthma and having cough or wheeze in the last 12 months and having used an asthma medication in the last 12 months. Atopy was measured by skin prick tests to six common allergens. RESULTS The prevalence of recent asthma was 22% in Lismore and 18% in Wagga Wagga. Factors which increased the risk of recent asthma were: atopy (odds ratio (OR) 2.35, 95% CI 1.49 to 3.72), having a parent with a history of asthma (OR 2.05, 95% CI 1.34 to 3.16), having had a serious respiratory infection in the first 2 years of life (OR 1.93, 95% CI 1.25 to 2.99), and a high dietary intake of polyunsaturated fats (OR 2.03, 95% CI 1.15 to 3.60). Breast feeding (OR 0.41, 95% CI 0.22 to 0.74) and having three or more older siblings (OR 0.16, 95% CI 0.04 to 0.71) decreased the risk of recent asthma. CONCLUSIONS Of the factors tested, those that have the greatest potential to be modified to reduce the risk of asthma are breast feeding and consumption of polyunsaturated fats.
Proxy decision making for incompetent patients. An ethical and empirical analysis
Authors: E. J. Emanuel
Journal: JAMA (1992)

RECENTLY, proxy or surrogate decision making regarding the termination of life-sustaining interventions for incompetent patients has been widely endorsed and promoted. After the<i>Cruzan</i>decision and the Patient Self-Determination Act of 1990, many states enacted proxy statutes specifically for health care. Indeed, even states such as New York and Massachusetts, which in the past had avoided enacting any legislation on living wills and securing the rights of patients, have quickly adopted See also pp 2082 and 2101. health care proxy laws. Simultaneously with this growing enthusiasm for proxy decision making have arisen ethical and empirical doubts about whether proxies can select interventions that the patient would have selected. These divergent trends confront us just as there is a growing need to develop policies on this issue. Consequently, it is important to examine several questions on proxy decision making: How widely endorsed is proxy decision making? What is the justification of
Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): Explanation and Elaboration
Authors: Jan P Vandenbroucke, Erik von Elm, Douglas G Altman, Peter C Gøtzsche, Cynthia D Mulrow, Stuart J Pocock, Charles Poole, James J Schlesselman, Matthias Egger
Journal: PLoS Medicine (2007)

Much medical research is observational. The reporting of observational studies is often of insufficient quality. Poor reporting hampers the assessment of the strengths and weaknesses of a study and the generalisability of its results. Taking into account empirical evidence and theoretical considerations, a group of methodologists, researchers, and editors developed the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) recommendations to improve the quality of reporting of observational studies. The STROBE Statement consists of a checklist of 22 items, which relate to the title, abstract, introduction, methods, results and discussion sections of articles. Eighteen items are common to cohort studies, case-control studies and cross-sectional studies and four are specific to each of the three study designs. The STROBE Statement provides guidance to authors about how to improve the reporting of observational studies and facilitates critical appraisal and interpretation of studies by reviewers, journal editors and readers. This explanatory and elaboration document is intended to enhance the use, understanding, and dissemination of the STROBE Statement. The meaning and rationale for each checklist item are presented. For each item, one or several published examples and, where possible, references to relevant empirical studies and methodological literature are provided. Examples of useful flow diagrams are also included. The STROBE Statement, this document, and the associated Web site (http://www.strobe-statement.org/) should be helpful resources to improve reporting of observational research.
Effects of Drinking Water Monochloramine on Lipid and Thyroid Metabolism in Healthy Men
Authors: Robert G. Wones, Colleen C. Deck, Betsy Stadler, Suzanne Roark, Elizabeth Hogg, Lawrence A. Frohman
Journal: Environmental Health Perspectives (1993)

The purpose of this study was to determine whether a 4-week consumption of 1.5L per day of drinking water containing monochloramine at a concentration of 2 ppm (ppm = mg/L) or 15 ppm under controlled conditions would alter parameters of lipid or thyroid metabolism in healthy men. Forty-eight men completed an 8-week protocol during which diet (600 mg cholesterol per day, 40% calories as fat) and other factors known to affect lipid metabolism were controlled. During the first 4 weeks of the protocol, all subjects consumed distilled water. During the second 4 weeks, one-third of the subjects were assigned randomly to drink 1.5 L per day of water containing 2 ppm of monochloramine, to drink 1.5 L per day of water containing 15 ppm monochloramine, or to continue drinking distilled water. Four blood samples were collected from each subject at the end of each 4-week study period. Subjects drinking monochloramine at a concentration of 2 ppm showed no significant changes in total cholesterol, triglycerides, HDL cholesterol, LDL cholesterol, apolipoproteins A1, A2, or B when compared to the distilled water group. Parameters of thyroid function also were unchanged by exposure to monochloramine at this concentration. However, subjects drinking monochloramine at a concentration of 15 ppm experienced an increase in the level of apolipoprotein B. Other parameters of lipid and thyroid metabolism did not change. We conclude that consumption of drinking water containing 2 ppm of monochloramine does not alter parameters of lipid and thyroid metabolism in healthy men. Consumption of water containing 15 ppm monochloramine may be associated with increased levels of plasma apolipoprotein B.
Contents
Authors: Sarah Eppley, Steven Mansberger, Saras Ramanathan, Eugene Lowry, Bing Zhang, Yusrah Shweikh, Anthony Frcophth, John Khawaja, Sarah Gallacher, Paul Foster, Sylvia Groth, Eiyass Albeiruti, Mariana Nunez, Roman Fajardo, Lucie Sharpsten, Nils Loewen, Joel Schuman, Jeffrey Goldberg, Justin Nguyen, Jeannie Nguyen-Cuu, Fei Yu, Kenneth Yee, Jonathan Mamou, Ronald Silverman, Jeffrey Ketterling, J Sebag
Journal: Ophthalmology (2019)
Exposure to Infant Siblings During Early Life and Risk of Multiple Sclerosis
Authors: Klemens Ruprecht, Hervé Perron
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hepatic inflammation upregulates netrin-1 in mice and in vitro through translational activation and transcript topology alteration in a LA-related protein-1 (LARP1)-dependent manner
Authors: Romain Barnault, Maud Michelet, Anna Rita Redavid, Federica G Centonze, Hesso Farhan, Benjamin Gibert, Patrick Mehlen, Fabien Zoulim, Romain Parent
Journal: Journal of Hepatology (2020)
Coal workers' pneumoconiosis. Correlation of roentgenographic and postmortem findings
Authors: R. L. Naeye
Journal: JAMA (1972)

Coal workers' pneumoconiosis is not a single disease process but a composite of multiple disorders, each of which may vary in incidence and severity from one patient to another. In a study of 77 miners of bituminous coal, roentgenographic categories for pneumoconiosis were found to correlate well with quantitative, postmortem anatomic measurements of (1) the volume of pulmonary dust macules and nodules, and (2) the silica (silicon dioxide) and collagen content of dust macules and nodules. Unfortunately, there was poor roentgenographic recognition of emphysema and chronic cor pulmonale, the two disorders which appear to be most closely correlated with dyspnea. A number of miners with no roentgenographic evidence of pneumoconiosis had emphysema, cor pulmonale, and dyspnea in addition to dust macules with silica and collagen.
Abstract 4520: Lymphatic vessels regulate exosome trafficking from tumors
Authors: Lea Maillat, Lambert Potin, Witold W. Kilarski, Melody A. Swartz
Journal: Cancer Research (2019)

Abstract Prior to metastasis, tumor-draining lymph nodes and distant organs are altered by a number of tumor-derived factors that help to both suppress host immunity as well as form an environment that supports metastatic tumor cells, i.e., a pre-metastatic niche. Recent studies suggest that pre-metastatic niches are induced by vesicles, including exosomes, secreted by tumor cells and cells of the tumor microenvironment. Here, we investigated the contribution of lymphatic vessels, particularly the lymphatic endothelial cells (LECs), in the active regulation of tumor exosome production and trafficking. To track exosomes, we purified and fluorescently labeled exosomes from in vitro cultures of the mouse melanoma cell line B16 F10 and of the human melanoma cell line Me260LN. Upon injection into the mouse ear dermis, fluorescent exosomes were observed within minutes in draining lymphatics, but not in surrounding blood vessels. Using the B16 F10 melanoma model overexpressing the lymphangiogenic growth factor VEGF-C, we found that upon intratumoral injection of exosomes, LECs within the tumor microenvironment abundantly take up exosomes, and at higher levels than blood endothelial cells, delivering exosomes to draining lymph nodes and eventually to the blood. In transgenic mice lacking dermal lymphatics, exosomes injected intratumorally were absent in the lymph nodes and present in far lower amounts in the blood compared to those injected into wild type mice. Additionally, while the density of endogenous blood exosomes increased upon tumor growth in wild type mice, no significant change in blood exosome density was observed in transgenic mice. Using an in vitro model where LECs are seeded onto porous inserts, we found that LEC transport of tumor exosomes occurs preferentially from their basal to apical side, and that some of these exosomes were taken up and stored intracellularly. Together, these findings suggest that lymphatic vessels constitute a major route of tumor exosome distribution to the systemic circulation and that LECs actively regulate exosome transport by active uptake. Citation Format: Lea Maillat, Lambert Potin, Witold W. Kilarski, Melody A. Swartz. Lymphatic vessels regulate exosome trafficking from tumors [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4520.
LOWERING THE BLOOD PRESSURE WITH LIVER EXTRACT
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal