tbuckley/cabot-search huggingface dataset:
Gazette Médicale de France, Paris
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Library sale.
Journal: BMJ (1969)

reduce needless repetition of blood counts in cases at present considered borderline.The following ranges (expressing cells per cu.mm. of blood) are proposed, and for comparison the current ranges are given in brackets: total leucocyte count, 4,000-11,500 (4,000-10,000); neutrophils, 2,000-7,500 (2,500-7,500); lympho-
RAWP revisited
Authors: A D Collings
Journal: BMJ (1987)

Parathyroid carcinoma (PC) is an uncommon finding, accounting for only 1-2% of patients with primary hyperparathyroidism (HPT), but a relatively higher incidence has been reported in Italy and Japan. The etiology of the tumour remains unclear, but molecular analysis studies have hypothesised the involvement of mutations of several genes in the pathogenesis of PC, including the oncogene cyclin D1 or PRAD1 located at the chromosome 13, the retinoblastoma and the p53 tumour suppressor gene. The clinical presentation of patients with PC is mainly related to the increased secretion of PTH rather than to the tumour burden. The pre-operative diagnosis of malignancy is very difficult to obtain, and, thus, intra-operative recognition of PC is mandatory. However, reliable signs of malignancy are rarely detectable. Probably, only vascular invasion, that correlates with tumour recurrence and metastases, should be considered useful in confirming malignancy, although both Ki-67 and Cyclin D1 have been recently used to aid in the definitive diagnosis. The en bloc resection of the tumour, together with ipsilateral thyroid lobe and adjacent structures, only if involved, avoiding any capsular rupture of the mass, represents the gold standard of surgical treatment of patients. Although the PC has traditionally been considered as a radioresistant tumour, there are some retrospective data holding a possible benefit from post-operative irradiation. No cytotoxic regimen with proven efficacy is currently available for patients with PC, but since hypercalcemia is ultimately the most frequent cause of death, several studies have suggested the usefulness of bisphosphonates (i.e., clodronate, pamidronate and zoledronate), calcitonin, and calcimimetic agents (i.e., cinacalcet) in patients with PC and severe hypercalcemia. In conclusion, PC is a rare malignancy and the NCDB survey reports an overall five- and ten-year survival rate of 85% and 49%, respectively. However, it is very difficult to predict the clinical behaviour of patients with PC and probably the ultimate prognosis depends on successful resection of the tumour at the initial surgery.
Correction
Journal: JAMA (1984)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Manuscripts Approved for JNCI During October–November, 1975
Journal: JNCI Journal of the National Cancer Institute (1975)

Journal Article Manuscripts Approved for JNCI During October–November, 1975 Get access JNCI: Journal of the National Cancer Institute, Volume 55, Issue 6, December 1975, Pages 1520–1522, https://doi.org/10.1093/jnci/55.6.1520-b Published: 01 December 1975
TC-99M GALACTOSYL-NEOGLYCOALBUMIN (TC-NGA): A PREDICTOR OF FUNCTIONING HEPATOCYTE MASS.
Authors: Robert C. Stadalnik, David R. Vera, Lois F. OʼGrady, Robert E. Quadro, Paul O. Scheibe, Kenneth A. Krohn, Dusan P. Hutak
Journal: Clinical Nuclear Medicine (1983)

Stadalnik, Robert C.; Vera, David R.; O'Grady, Lois F.; Quadro, Robert E.; Scheibe, Paul O.; Krohn, Kenneth A.; Hutak, Dusan P. Author Information
Leads from the MMWR. Regional differences in postneonatal mortality--Mississippi, 1980-1983
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Editorial Board
Authors: George Bartley, Henry Jampel, Daniel Albert, Andrew Schachat, Anita Agarwal, T Iqbal, Ike Ahmed, Jayakrishna Ambati, Tin Aung, Singapore Bengtsson, James Brandt, Wiley Chambers, Balwantray Chauhan, Emily Chew, Michael Chiang, Helen Danesh-Meyer, Marjan Farid, Steven Gedde, Lynn Gordon, Los Angeles, Mingguang He
Journal: Ophthalmology (2015)
Use and interpretation of diagnostic immunologic laboratory tests
Authors: K. J. Bloch
Journal: JAMA (1982)

<h3>ANTIBODIES AND IMMUNOGLOBULINS</h3><h3>Antibodies—The Secreted Products of Plasma Cells</h3> Antibodies are synthesized and secreted primarily by plasma cells, the progeny of B lymphocytes. Since many different clones of cells participate in the immune responses to a single antigen, antibodies are heterogeneous with respect to their structure and function. However, proteins carrying antibody activity, all of which migrate electrophoretically as γ-globulins, belong to different immunoglobulin classes (ie, IgG, IgA, IgM, IgD, and IgE). All immunoglobulins are composed of two polypeptide chains of different molecular size, the light and heavy chains. A monomeric immunoglobulin molecule consists of two heavy and two light chains. These polypeptide chains are arranged in the shape of a Y (Fig 20-1). The arms of the Y are composed of the amino-terminal halves of the heavy chain and the entire light chain, while the carboxyterminal halves of the two heavy chains constitute the stem. The arms and the
Mixed feelings
Authors: Karen A O'Reilly
Journal: BMJ (2007)

We welcome your rapid responses, whether in direct response to an article in Career Focus or as a way of sharing your own ideas. As long as it isn9t libellous or offensive, we9ll post it on our website. We print a selection of rapid reponses here and the writer of the best each month wins an <i>Oxford Handbook</i> of their choice. Letter of the month prize is donated by OUP.
Listeriosis
Authors: Bruce G. Gellin
Journal: JAMA (1989)

<i>LISTERIA monocytogenes</i>has been recognized as a human pathogen for more than 50 years; it causes illness mainly in pregnant women, newborns, elderly persons, and immunocompromised persons. The organism is found in multiple ecological sites and throughout the food chain, and anecdotal reports have linked human illness with the ingestion of foods contaminated with<i>Listeria</i>.<sup>1</sup>More recently, it has been shown to cause outbreaks of illness that were associated with commercial food products.<sup>2-5</sup>The Food and Drug Administration has recommended product recalls when<i>L monocytogenes</i>has been identified in commercial foods that are available for consumption without further cooking. Although recalls have generated widespread public concern, information about the magnitude of risk and the clinical presentations of disease has not been widely available to the medical community. This article reviews the history, microbiology, ecology, pathogenesis, epidemiology, and clinical spectrum of human illnesses caused by<i>L monocytogenes</i>and highlights
Hydrohaematocolpos.
Authors: M. K. Joseph, B. T. Nayar, M. Kannankutty
Journal: BMJ (1966)

Preliminary Communications MBALM 89possible to make exfoliative cytology less subjective and more decisive, and consequently easier to apply.The evidence of a characteristically high activity of enzymes of the hexose monophosphate shunt in smears from cases of known carcinoma of the cervix suggests the possibility of a " histo- chemical stain " which might assist the interpretation of smears.SUMMARY It is possible to demonstrate respiratory enzyme activity on scrape smears from the uterine cervix.Because cancer cells show a more intense reaction for the dehydrogenases of the hexose-monophosphate pathway than normal cells, it may be possible to develop a histochemical stain to assist interpretation of smears.
Lectures on the Pathology, Diagnosis, and Treatment of Bright's Disease
Authors: G. Johnson
Journal: BMJ (1873)

S DISEASE.-(Concbuded.) THE treatment of chronic Bright's disease must obviously vary accord- ing to the form and stage of the malady and the nature of the secondary complications.In each case, it is practically important to ascertain, if possible, the probable cause of the renal disease.Your inquiries should be directed to determine whether the chronic malady is a sequel of an acute attack, or whether it commenced as an insidious chronic disease.Then you should make inquiry as to the exciting cause, which in most cases may be arrived at with a high degree of probability.Is there a history of gout, or of habits likely to induce a gouty diathesis ?Ex- cessive eating and drinking, chronic dyspepsia, frequent exposure to cold and wet, cachexia the result of syphilis or of other constitutional disease, scrofula or other possibly hereditary taint, and chronic lead- poisoning, are amongst the probable determining causes which should be made the subject of inquiry; and then the treatment should be directed to remove, if possible, or, so far as may be, to counteract, the morbific influence.Whatever may be the form or the stage of chronic Bright's disease, the skin must be protected from cold by warm woollen clothing, care must be'taken to avoid over-fatigue, and the diet should be carefully regulated both as to quantity and quality.As a rule, in all cases of chronic renal disease, alcoholic stimulants in any form should be given sparingly, or abstained from entirely, unless, for some special reason, they appear to be indicated.You will find that, when there is extensive degeneration of the kidney, alcoholic liquors usually produce far more decided, durable, and often deleterious effects, than result from equal quantities of the same liquors when the kidneys have their normal structure and functional activity.In one class of cases-cases of large white kidney, with a scanty secretion of highly albuminous urine-dropsy is usually a prominent symptom, and requires special treatment.The tendency to dropsy is no doubt increased by the dry and inactive state of the skin, which often resists the relaxing effect of external warmth, so that a hot-air bath, or even the hottest room of a Turkish bath, fails to excite diaphoresis.Patients who do not perspire under the influence of the hot-air bath, usually complain of painful throbbing in the head, diffi- cult breathing, and other distressing symptoms.On this account, I prefer in most cases the wet sheet and blanket bath, which, as a diaphoretic, is both more agreeable and more efficacious than the hot- air bath.
Military medical 'commuting' may mean flying 12 hours to a turnkey hospital in mid-Europe
Authors: C. Raymond
Journal: JAMA (1989)

THEY DON'T CALL it an adventure. They call it "TDY"—temporary duty. In this case, the task was to simulate readying a contingency hospital to minister to battlefield casualties flown in by helicopter. Early in the fall, 204 Air Force medical personnel, primarily from Carswell Air Force Base, Fort Worth, Tex, descended on Zweibrücken Air Base, West Germany, having spent 12 hours refining their skills at cards, small talk, and sleep while huddled in a cold and cramped C-141 "Starlifter" cargo plane crossing above the Atlantic. <h3>Scrub Down Before Scrubbing In</h3> When they arrived, their first task was to meticulously scrub down the operating rooms and wards. The German hospital is a turnkey facility—meaning that all supplies are on hand—but the skeleton caretaking crew doesn't do windows. Or floors or walls, for that matter. In less than 48 hours, the seven physicians, two dentists, and dozens of nurses and corpsmen were
Functional significance of stenoses in coronary artery bypass graftsEvaluation by single-photon emission computed tomography perfusion imaging, cardiovascular magnetic resonance, and angiography
Authors: L SALM, J BAX, H VLIEGEN, S LANGERAK, P DIBBETS, J JUKEMA, H LAMB, E PAUWELS, A DEROOS, E VANDERWALL
Journal: Journal of the American College of Cardiology (2004)
Book Reviews
Journal: British Journal of Dermatology (1986)

British Journal of DermatologyVolume 114, Issue 4 p. 523-526 Book Reviews First published: April 1986 https://doi.org/10.1111/j.1365-2133.1986.tb02872.xAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Book Reviews in this article: The Urticarias. Edited by R.H.Champion, M.W.Greaves, A.Kobza Black and R.J.Pye Plant Contact Dermatitis. Cl.Benezra, G.Ducombs, Y.Sell and J.Foussereau Clinical Dermatology: A Colour Guide to Diagnosis and Therapy. Thomas P.Habif. Practical Genetic Counselling. P.S.Harper Handbook of Paediatric Dermatology. J.Harper Contact Allergy: Predictive Tests in Guinea-Pigs (Current Problems in Dermatology, Volume 14). Edited by K.E.Andersen and H.I.Maibach Psoriasis. Edited by H.H.Roenigk, jr. and H.I.Maibach Volume114, Issue4April 1986Pages 523-526 RelatedInformation
Folic Acid in Blood in Nutritional Megaloblastic Anemias
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Radionuclide Injury to the Lung
Authors: G. E. Dagle, C. L. Sanders
Journal: Environmental Health Perspectives (1984)

Radionuclide injury to the lung has been studied in rats, hamsters, dogs, mice and baboons. Exposure of the lung to high dose levels of radionuclides produces a spectrum of progressively more severe functional and morphological changes, ranging from radiation pneumonitis and fibrosis to lung tumors. These changes are somewhat similar for different species. Their severity can be related to the absorbed radiation dose (measured in rads) produced by alpha, beta or gamma radiation emanating from various deposited radionuclides. The chemicophysical forms of radionuclides and spatial-temporal factors are also important variables. As with other forms of injury to the lung, repair attempts are highlighted by fibrosis and proliferation of pulmonary epithelium. Lung tumors are the principal late effect observed in experimental animals following pulmonary deposition of radionuclides at dose levels that do not result in early deaths from radiation pneumonitis or fibrosis. The predominant lung tumors described have been of epithelial origin and have been classified, in decreasing frequency of occurrence, as adenocarcinoma, bronchioloalveolar carcinoma, epidermoid carcinomas and combined epidermoid and adenocarcinoma. Mesothelioma and fibrosarcoma have been observed in rats, but less commonly in other species. Hemangiosarcomas were frequency observed in dogs exposed to beta-gamma emitters, and occasionally in rats exposed to alpha emitters. These morphologic changes in the lungs of experimental animals were reviewed and issues relevant to the prediction of human hazards discussed.
Response
Authors: D. S. MARTIN, R. L. STOLFI, J. R. COLOFIORE
Journal: JNCI Journal of the National Cancer Institute (1989)

Journal Article Response Get access DANIEL S. MARTIN, DANIEL S. MARTIN Department of Surgery Research, Catholic Medical Center of Brooklyn and Queens, Inc.89-15 Woodhaven Blvd. Woodhaven, NY 11421 Search for other works by this author on: Oxford Academic PubMed Google Scholar ROBERT L. STOLFI, ROBERT L. STOLFI Department of Surgery Research, Catholic Medical Center of Brooklyn and Queens, Inc.89-15 Woodhaven Blvd. Woodhaven, NY 11421 Search for other works by this author on: Oxford Academic PubMed Google Scholar JOSEPH R. COLOFIORE JOSEPH R. COLOFIORE Department of Surgery Research, Catholic Medical Center of Brooklyn and Queens, Inc.89-15 Woodhaven Blvd. Woodhaven, NY 11421 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 81, Issue 6, 15 March 1989, Pages 460–461, https://doi.org/10.1093/jnci/81.6.460 Published: 15 March 1989
太阳紫外线辐射如何影响皮肤基因的研究
Authors: M. Bustamante, C. Hernandez‐Ferrer, A. Tewari, Y. Sarria, G.I. Harrison, E. Puigdecanet, L. Nonell, W. Kang, M.R. Friedländer, X. Estivill, J.R. González, M. Nieuwnhuijsen, A.R. Young
Journal: British Journal of Dermatology (2020)

太阳主要发射两种类型的紫外线(UVR):UVB(~5%) 和 UVA(~95%)。我们知道,来自太阳的 UVR 会导致晒伤(炎症)以及许多其他不利的(负面)影响,包括削弱皮肤的免疫力,加速皮肤老化和引起皮肤癌。 这些效应是由于紫外线照射改变皮肤基因,即所谓的“转录组”的活性(表达)引起的。基因的行为决定了身体对外界潜在破坏性压力的反应。研究皮肤转录组的体内(在人类中)变化可以让我们了解皮肤细胞在单次 UVR 照射(剂量)后被激活的通路。这些知识对于制定预防阳光不利影响的策略很重要。 在这项研究中,作者让七名健康、皮肤白皙的志愿者接受了在一天的阳光假期中可轻松受到的 UVR 辐射量后检测了他们的皮肤转录组反应。 作者表明,假期情况下接受的典型 UVR 辐射量会导致多种皮肤基因表达的显著变化。最引人注目的是涉及皮肤最外层更新(一种保护性反应)、炎症、免疫系统反应和加速皮肤老化的基因。UVR 剂量越高,受影响基因数量越多。 一个非常有趣的观察现象是参与维生素 D 生成的基因的活性被抑制(减弱),这表明身体有自己的机制来控制皮肤中的维生素 D 毒性 (过多的维生素 D)。 研究还显示,在引起基因表达变化方面,UVB 通常比 UVA 更有效,这与其它研究相一致,其它研究表明,UVB 在引起皮肤分子和临床变化方面要比 UVA 强大得多。 本摘要涉及研究: 模拟太阳的紫外线辐射对人类体内皮肤转录组的剂量和时间效应
Effects of Respiration and Gravity on Infradiaphragmatic Venous Flow in Normal and Fontan Patients
Authors: Tain-Yen Hsia, Sachin Khambadkone, Andrew N. Redington, Francesco Migliavacca, John E. Deanfield, Marc R. de Leval
Journal: Circulation (2000)

Background —In the Fontan circulation, pulmonary and systemic vascular resistances are in series. The implications of this unique arrangement on infradiaphragmatic venous physiology are poorly understood. Methods and Results —We studied the effects of respiration and gravity on infradiaphragmatic venous flows in 20 normal healthy volunteers (control) and 48 Fontan patients (atriopulmonary connection [APC] n=15, total cavopulmonary connection [TCPC] n=30). Hepatic venous (HV), subhepatic inferior vena caval (IVC), and portal venous (PV) flow rates were measured with Doppler ultrasonography during inspiration and expiration in both the supine and upright positions. The inspiratory-to-expiratory flow rate ratio was calculated to reflect the effect of respiration, and the supine-to-upright flow rate ratio was calculated to assess the effect of gravity. HV flow depended heavily on inspiration in TCPC compared with both control and APC subjects (inspiratory-to-expiratory flow rate ratio 3.4, 1.7, and 1.6, respectively; P &lt;0.0001). Normal PV flow was higher in expiration, but this effect was lost in TCPC and APC patients (inspiratory-to-expiratory flow rate ratio 0.8, 1.0, and 1.1, respectively; P =0.01). The respiratory influence on IVC flow was the same in all groups. Gravity decreased HV flow more in APC than in TCPC patients (supine-to-upright flow rate ratio 3.2 versus 2.1, respectively; P &lt;0.04) but reduced PV flow equally in all groups. Conclusions —Gravity and respiration have important influences on infradiaphragmatic venous return in Fontan patients. Although gravity exerts a significant detrimental effect on lower body venous return, which is more marked in APC than in TCPC patients, the beneficial effects of respiration in TCPC patients are mediated primarily by an increase in HV flow. These effects may have important short- and long-term implications for the hemodynamics of the Fontan circulation.
Editor's Note: Genomic and Molecular Characterization of Malignant Peripheral Nerve Sheath Tumor Identifies the IGF1R Pathway as a Primary Target for Treatment
Authors: Jilong Yang, Antti Ylipää, Yan Sun, Hong Zheng, Kexin Chen, Matti Nykter, Jonathan Trent, Nancy Ratner, Dina C. Lev, Wei Zhang
Journal: Clinical Cancer Research (2019)