tbuckley/cabot-search huggingface dataset:
BOOK REVIEWS
Journal: British Journal of Dermatology (1964)

British Journal of DermatologyVolume 76, Issue 11 p. 499-499 BOOK REVIEWS First published: November 1964 https://doi.org/10.1111/j.1365-2133.1964.tb15497.xAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Book reviews in this article Venereal Diseases. A. KING and C. NICOL Recent Advances in Venereology. A. King Year Book of Dermatology (1963-1964) R. L. BAEB and A. W. KOPF. Volume76, Issue11November 1964Pages 499-499 RelatedInformation
Phase II study of gemcitabine, cisplatin, and sunitinib in patients with advanced urothelial carcinoma (UC).
Authors: M. D. Galsky, G. Sonpavde, B. A. Hellerstedt, S. A. McKenney, T. E. Hutson, M. A. Rauch, Y. Wang, K. A. Boehm, L. Asmar
Journal: Journal of Clinical Oncology (2010)

4573 Background: Preclinical/clinical data support targeting angiogenesis in UC. Single-agent sunitinib (S) has activity in patients with advanced UC (Gallagher ASCO 09); bladder cancer xenograft studies suggest additive activity when combining S+cisplatin (C) (Sonpavde Urol Onc 09) providing rationale for exploring combined gemcitabine (G)+C+S. Methods: This phase II study in chemonaïve advanced UC had a planned enrollment of 43 patients. The dose and schedule were based on a phase I study (Reck ASCO 07). Patients received G 1000 mg/m2 IV (Days 1 & 8), C 70 mg/m2 IV (Day 1), and S 37.5 mg PO daily (Days 1-14)/each 21-day cycle (up to 6 cycles), followed by S 37.5 mg daily until progression. Results: From December 2008 to August 2009, 15 eligible patients enrolled; prognostic factors at baseline: KPS <80% in 0% and visceral metastases in 87%; median age was 65 years (range, 58-82). Five of 15 patients discontinued treatment early (median: 3 cycles) due to toxicity, most often due to cytopenias requiring recurrent dose reductions beyond allowed per protocol. Intrapatient dose reductions were required for G (12/15), C (8/15), and S (10/15). Six of 15 patients experienced serious adverse events including 1 patient with neutropenic sepsis/death and another with a cardiovascular accident. Based on these safety findings, the 5 patients still receiving S were instructed to discontinue treatment. The most frequent Grade 3-4 toxicities were neutropenia (80%), thrombocytopenia (60%), anemia (20%), and leucopenia (13%). Preliminary updated antitumor activity included unconfirmed complete response (6.7%); partial responses (26.7%), unconfirmed PR (26.7%), stable disease (13.3%), not evaluable (20%), and progressive disease (6.7%). Conclusions: Despite intriguing preliminary activity, at this dose and schedule, the combination of G+C+S was not tolerable; Inhibition of kinases flt-3 and c-kit may account for the additive hematologic toxicity. Exploration of alternative dosing regimens or combinations with more selective antiangiogenic agents are warranted. Based on these preliminary results, the study has reopened to enrollment with an alternative dosing scheme. Supported, in part, by a grant from Pfizer, Inc. Author Disclosure Employment or Leadership Position Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Pfizer Myriad Genetics, Novartis, Pfizer, Wyeth Pfizer
CHAIRMAN'S ADDRESS.
Authors: EDWARD H. SMALL
Journal: JAMA (1895)

We are met together in the sixteenth annual meeting of the Section on Diseases of Children, which was the sixth Section to be formed in theAmerican Medical Association. This Section was organized under the chairmanship of Dr. S. C. Busey of Washington, in the city of New York, in 1880, with an attendance of about forty members. At this first meeting but five papers were read, and the discussion was carried on by some ten gentlemen. Since then the fortunes of the Section have varied. At one time, interest in it had so declined that a motion was offered that the Section be done away with. Fortunately, this motion was not passed. The best meeting that the Section ever held was that in Milwaukee in 1893. The program arranged for this present meeting has been gotten up to as great an extent as possible on the lines of the
The Goulstonian Lectures on Puerperal Fever
Authors: R. J. Lee
Journal: BMJ (1875)

It is impossible to discuss in detail the thirty-two cases I have placed in this group; but it is certain that the characteristic features of the supra- renal lesion in Addison's disease are not described in any one of them.I must, however, advert to the most recent of these cases, puiblished by Dr.Wickham Legg, in the last volume of the St. Bartholomew's Hospital Re- Ports.The patient, a woman aged 37, unquestionably exhibited some of the constitutional symptoms of Addison's disease, for she suffered foreighteen months from debility, shortness of breath, occasional vomiting of food, and constipation, and she die(d after five weeks' residenice in the hos- pital, of vomiting and exlhaustion.But, on the other hand, there was a distinct bilious tendency to explain the vomiting ; the appetite was fair, and there was great thirst, with a red fissured tongue, swollen spongy gums, and a temnperature above tlse normal.MIore- over, the patient had lost four stones in wveight during her illness: an absolutely unprecedented circuimstance in Addison's disease, unless whlen resulting from some serious coexisting wasting disease.The discoloured skin, also, was harsh, dry and warm, instead of being soft and cool, and was not more deeply pigmented in the axille or areolm of the nipples than at other parts.At the z6ost mortem examination, the right suprarenal capsule could niot be found, its place being filled by a mass of yellow fat; andI the left was only represented by a black body as thin as paper.This wvas a most peculiar and interesting condi- tion of the suprarenal capsules, btut it obviously bore no relation whatever to Addison's disease of those organs ; nor were the constitutional symp- toms and discoloration of skin, taken as a whole, characteristic of that disease.The most difficult point in the case is the absence of any apparent cause of illness and death.One. case remains of the whole number collected, which represents another misconception so remarkable, that it cannot be entirely passed over.The case is related by Dr. Gilliam of the United States, and is that of a man aged 45, who suffered from many of the constitutional symptoms of Addison's disease.Gradually increasing debility, dyspncea and palpitation on exertion, loss of appetite, and tendency to vomiting, which became more and more obstinate until the patient died of ex- haustion-were symptoms which, in the absence of any other discover- able cause might fairly lead to a diagnosis of Addison's disease, although no discoloration of skin wias present.But when, after death, not only were the suprarenal capsules found to be healthy, but advanced degeneration and atrophy of the gastric tubules were discovered, which, as the author himself observed, fully accounted for all the symptoms, the diagnosis had clearly been a mistake.From this case, however, Dr. Gilliam concludes, first, that the bronzing of the skin is quite an unimportant feature of Addisoil's disease ; and, secondly, that Addi-
The Use of Autologous Blood
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
STRENGTHEN THE ASSOCIATION.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Human Trophoblast
Authors: John W. Huffman
Journal: JAMA (1969)

Arthur Hertig was bent over a dissecting microscope in the laboratory of Boston Lying-In Hospital, teasing apart the villi of a young abortus, the first time I saw him. That was in 1937. He has spent much of the intervening years exploring and exposing the mysteries of normal and abnormal placental development. As a result he undoubtedly knows more about the human trophoblast than any other living person. His observations on the diseased trophoblast are a corollary of his studies of the abundant material he has had available at Boston Lying-In Hospital and Boston Hospital for Women. The jacket states that this book is by and for pathologists. That is a disservice to many physicians, particularly obstetricians, who may feel that the text is too ponderous or too specialized for them to appreciate. Nothing could be more untrue. In the first 140 pages is a masterful review of the growth
Endpiece: Knowledge
Authors: A. Einstein
Journal: BMJ (1999)

if recall rates do fall, one view double reading (consensus) is also an efficient option. Importance of baselineThe analysis presented here emphasises the importance of having an appropriate baseline in economic evaluations and of using incremental analysis to identify efficient options.If we had presented only the overall cost effectiveness ratio for two view mammography at incident screens in England and Wales, the prioritisation of change in policy for the programmes currently using one view and single reading would have been missed.We thank Roger Blanks and Sue Moss of the Cancer Screening Evaluation Unit, Institute of Cancer Research, for advice and for comments on an earlier draft.
Allegiance to the corps. The physician's dilemma
Authors: B. W. Smith
Journal: JAMA (1984)

IN RESIDENCY training programs around the country, a wave of physicians with obligations to the National Health Service Corps (NHSC) is now cresting. These physicians held NHSC scholarships as medical students, and on completion of residency training approved by the Corps they must begin a period of service equal in years to the length of time that they were supported by the NHSC as medical students. The recipients of the last large batch of NHSC scholarships were freshmen in medical school four years ago and are now in their first year of residency training. The wave of NHSC scholarship students has already passed through the medical schools, and by 1987 it will have passed through most residencies as well. Thereafter, communities that would have trouble attracting physicians without the special inducement of the NHSC service obligation may find themselves medically abandoned. This article proposes a strategy for averting that predictable
NCCN NewsNCCN Announces First Patient Dosed in NCCN-Peregrine Pharmaceuticals Collaborative Study of BavituximabNCCN Chemotherapy Order Templates to be Integrated Into MEDITECH's Web EHRNCCN Guidelines to be Integrated into the Evinance Decision Support Platform
Authors: Ranee Mehra
Journal: Journal of the National Comprehensive Cancer Network (2017)

Glioblastoma is the most common malignant primary brain tumor and is a uniformly fatal disease, with 5-year survival rates of <4% despite aggressive treatment with surgery, radiation, and chemotherapy. 1Consequently, new therapies for this patient population are desperately needed.NCCN announced the dosing of the first patient in its Oncology Research Program (ORP)-funded study to investigate the effectiveness of bavituximab with radiation and temozolomide in patients with newly diagnosed glioblastomas.The study, initiated by Elizabeth Gerstner, MD, Massachusetts General Hospital Cancer Center, is 1 of 3 studies funded through a collaboration between NCCN ORP and Peregrine Pharmaceuticals-this patient marks the first enrollment into an NCCN ORPfunded investigator-initiated bavituximab trial.
Hemarthrosis from heparin therapy
Authors: W. B. Hale
Journal: JAMA (1980)

<h3>In Reply.—</h3> Dr Sabom takes me to task for describing the episodes as "fantasy." By using this word, I locate the phenomenon within the patient's psyche. Dreams and hallucinations may also be vivid, "visual" representations experienced as occurring outside oneself, yet we have no difficulty in recognizing them as mental productions. The alternative to the intrapsychic location would be one of something (the soul?) leaving the person in reality and hovering over the table. I do not think one has to apologize for scientific belief if one does not accept the ideas of spirits wandering around the emergency room. Rather than seeking an adequate medical explanation, one can fairly wonder about an adequate psychological explanation. Here Dr Sabom might wonder about the similarity of many of the episodes, even cross-culturally, and might relate this to what have been described as typical dreams. Since blood gases obviously cannot be monitored in
Ethics Committees, Due Process, and Compassion
Authors: Thomas E. Finucane
Journal: Annals of Internal Medicine (1994)

Letters1 September 1994Ethics Committees, Due Process, and CompassionThomas E. Finucane, MDThomas E. Finucane, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-121-5-199409010-00039 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Both articles about ethics committees refer to the lack of due process when complex and often tragic decisions about care are made [1, 2]. In the nursing home, we frequently have ill, suffering patients with marginal ability to make decisions about burdensome treatments that might prolong life. How do we decide? The people who care for the patients and those who love them put their heads together and try to determine what is right.At one extreme, sick persons or their families could retain the services of a lawyer to ensure that all patients' rights were fully ...References1. Fleetwood J, Unger SS. Institutional ethics committees and the shield of immunity. Ann Intern Med. 1994; 120:320-5. Google Scholar2. Fletcher JC, Hoffman DE. Ethics committees: time to experiment with standards. Ann Intern Med. 1994; 120:335-8. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1994Volume 121, Issue 5Page: 386-387KeywordsNursing homesPatient advocacyPatients Issue Published: 1 September 1994 CopyrightCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
The Lumleian Lectures on the Digestive Ferments, and the Preparation and Use of Artificially Digested Food
Authors: W. Roberts
Journal: BMJ (1880)

Comotparisonz of tile Ae tion of Ptpsin and T;ypsin.-Theaction of pepsin and trypsin, although similar in the main results, is certainly not identical.There is a markedly larger production of leucin and tyrosin in tryptic than-in peptic digestion.Mloreover, the action of the two ferments on different proteids appears to vary both in character and in energy.Milk is nmuch more readily digested by pancreatic ex- tract than by artilicial gastric juice; but in the case of egg-albumen the advantage lies decidedly with the gastric juice.The study of the digestioA of egg-albumen by the two methods yielded some interesting results.I emiployed for this purpose a dilution of egg-albumen with water, in the proportion of one in ten.This remains uncoagulated after being boiled in the water-bath, and furnishes a favourable medium for studying the digestion of albumen-much more favourable than the chopped boiled white-of-egg usually employed.It permits the ferment to be at once brought into uniform and intimate contact with the particles
Failure to use seat belts in the United States. The 1981-1983 Behavioral Risk Factor Surveys
Authors: G. M. Goldbaum
Journal: JAMA (1986)

Although seat belt use could prevent thousands of highway deaths and save billions of dollars annually, most Americans do not routinely buckle up. To understand better this phenomenon and other health-related behaviors, 28 states, the District of Columbia, and the Centers for Disease Control, Atlanta, surveyed over 22,000 US adults from 1981 through 1983. Overall, 76% of US adults reported not using seat belts. Blacks, 18- to 24-year-olds, persons with no more than a high school education, and persons with other risk behaviors (especially drunk driving) were least likely to use seat belts. Legislation by the states and education by physicians can increase seat belt use and reduce morbidity and mortality due to motor vehicle collisions. (<i>JAMA</i>1986;255:2459-2462)
Corrections
Journal: BMJ (1894)

JOURNALISTS AND QUACKS.AFTER the Review of Reviews, the Daily News, after Mattei, Gatchkowsky.If the irresponsible, unblushing, and most mischievous patronage of the wildest and most senseless form of quackery were not nowadays so frequent in British journalism, the insertion of such an editorial paragraph as the subjoined in a journal of weight and standing, and enjoying a well-deserved political and literary reputation, would be incredible and impossible.But no excess of fatuous absurdity and no extremity of self-evident ignorance are beyond the credulity of the political journalist of to-day.Nevertheless, it was not without regret that we read in the Daily News of this week the subjoined editorial paragraph, which embodies, perhaps, as much impudent and mis- leading and extravagant pretension as any in the annals even of mediaeval darkness.The italics are ours." ' Vitaline,' a Cure for Consumption.-Abouteight years ago M. Gatch- kowsky, a Polish amateur chemist, struck, in the course of his medical studies, with the remarkable cures effected by the Chinese doctors, deter- mined to turn his energies in that direction, and, after a long series of experiments, succeeded in obtaining, as a result of an admixture of borax and glycerine (!), a compound for which the most extraordinary virtues are claimed.After elaborate analysis on the part of numerous celebrated (?) French doctors, 'Vitaline'-such being the name given by M. Gatch-
Hypoglycemia Unawareness in IDDM
Authors: Marian Mokan, Asimina Mitrakou, Thiemo Veneman, Christopher Ryan, Mary Korytkowski, Philip Cryer, John Gerich
Journal: Diabetes Care (1994)

OBJECTIVE To assess the characteristics of patients with hypoglycemia unawareness (development of neuroglycopenia without appropriate prior autonomic warning symptoms) and its predisposing factors. RESEARCH DESIGN AND METHODS We studied 43 insulin-dependent diabetes mellitus patients who were objectively categorized as having or not having hypoglycemia using the stepped hypoglycemic clamp technique in which plasma glucose was clamped at plateaus of 4.3, 3.6, 3.0, and 2.3 mmol/l and a statistical criterion (onset of autonomic warning symptoms at a plasma glucose concentration 2 SD below normal) and examined their clinical characteristics and hormonal, symptomatic, and cognitive responses. RESULTS Eleven (26%) of the patients were classified as having hypoglycemia unawareness. Compared with the other patients, unaware patients had a lower HbA1c level (P &amp;lt; 0.01), a longer duration of diabetes (P &amp;lt; 0.01), and a history of more severe hypoglycemia (P &amp;lt; 0.003). During experimental hypoglycemia, counterregulatory hormone responses, neuroglycopenic symptoms, and cognitive dysfunction all began at lower plasma glucose concentrations in unaware patients (P &amp;lt; 0.01, 0.03, and 0.01, respectively). Moreover, although the magnitudes of their plasma catecholamine responses and autonomic symptoms were reduced (both, P &amp;lt; 0.01), the plasma catecholamine levels at which autonomic symptoms began was not altered. Finally, as seen from glucose infusion rates necessary to maintain identical plasma glucose levels, patients with hypoglycemia unawareness had increased sensitivity to insulin (P &amp;lt; 0.001). CONCLUSIONS Our results confirm an association between hypoglycemia unawareness and duration of diabetes, glycemic control, and occurrence of severe hypoglycemia, and in addition provide evidence that both autonomic and neuroglycopenic symptoms are affected and that insulin sensitivity is increased, but β-adrenergic sensitivity is not diminished.
Hepatitis C Virus Transmission From an Antibody-Negative Organ and Tissue Donor—United States, 2000-2002
Journal: JAMA (2003)

In June 2002, a physician reported to the Oregon Department of Human Services (DHS) a case of acute hepatitis C in a patient who had received a patellar tendon with bone allograft from a donor approximately 6 weeks before onset of illness. At the time of the donor's death in October 2000, his serum had no detectable antibody to hepatitis C virus (anti-HCV). The ensuing investigation conducted by CDC and DHS confirmed that the donor, although anti-HCV-negative, was HCV RNA-positive and the probable source of HCV infection for at least eight organ and tissue recipients. This report summarizes the preliminary results of the investigation. Although transmission from anti-HCV-negative tissue donors probably is rare, determining the frequency of transplantations from such donors and the risk for transmitting HCV to recipients is important in evaluating whether additional prevention measures are warranted.