tbuckley/cabot-search huggingface dataset:
Truth Survival
Authors: Thierry Poynard
Journal: Annals of Internal Medicine (2002)

Letters3 December 2002Truth SurvivalThierry Poynard, MD, PhD, Mona Munteanu, MD, and Vlad Ratziu, MDThierry Poynard, MD, PhDGroupe Hospitalier Pitié-Salpêtrière; 75651 Paris, FranceSearch for more papers by this author, Mona Munteanu, MDGroupe Hospitalier Pitié-Salpêtrière; 75651 Paris, FranceSearch for more papers by this author, and Vlad Ratziu, MDGroupe Hospitalier Pitié-Salpêtrière; 75651 Paris, FranceSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-137-11-200212030-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We agree that very old publications declared obsolete or false in the year 2000 could cause the duration of survival to be overestimated if they were in fact obsolete or false many years earlier. However, this risk for survival overestimation does not concern the true conclusions that represent 60% of events.For each obsolete or false conclusion, we estimated the year in which it became obsolete or false. Most often it was 1980 for biochemical liver tests; 1980 for corticosteroid treatment of hepatitis; and 1990 for non-A, non-B hepatitis, γ-globulin studies, and studies of portal hypertension. A new ... Author, Article, and Disclosure InformationAuthors: Thierry Poynard, MD, PhD; Mona Munteanu, MD; Vlad Ratziu, MDAffiliations: Groupe Hospitalier Pitié-Salpêtrière; 75651 Paris, France PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoTruth Survival in Clinical Research: An Evidence-Based Requiem? Thierry Poynard , Mona Munteanu , Vlad Ratziu , Yves Benhamou , Vincent Di Martino , Julien Taieb , and Pierre Opolon Truth Survival Michael P. LaValley and David T. Felson Truth Survival William C. Holmes Metrics Cited byDonnées de vie réelle et recherche clinique : le complément des données des essais randomisés ?Hirsch Index and Truth Survival in Clinical Research 3 December 2002Volume 137, Issue 11Page: 932KeywordsEvidence based medicineGastroenterology and hepatologyHepatitisHepatitis BInterferonsLiverPortal hypertensionRandomized trialsSurvival analysis ePublished: 3 December 2002 Issue Published: 3 December 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Effects of H2-Receptor Antagonists on Blood Alcohol Levels
Authors: James Palmer
Journal: JAMA (1992)

<h3>To the Editor.</h3> —The article by DiPadova et al<sup>1</sup>reported that ranitidine and cimetidine, but not famotidine, increase blood alcohol concentrations when 0.3 g/kg ethanol is administered to men in the morning following breakfast. We have several comments and questions about this article. First, ethanol concentrations were measured by three different analytical methods (breath analyzer, plasma enzymatic assay, and plasma gas chromatography) in different subjects. While the authors imply that the methods gave virtually identical results, no further information was presented. Cross-validation of results is essential to exclude systematic differences between such diverse methods. We note that in previous articles published by Frezza et al<sup>2</sup>and Caballeria et al<sup>3</sup>on ethanol presystemic clearance, only one method was used in each study, rather than three methods. Second, the three assay methods are reported as blood alcohol concentrations. However, blood was not analyzed, and no conversion from plasma to
Food Labeling
Authors: Madelyn L Wheeler, Marion Franz, Joan Heins, Rebecca Schafer, Harold Holler, Betsy Bohannon, John P Bantle, Phyllis Barrier
Journal: Diabetes Care (1994)

In June 1990, the American Diabetes Association approved a food labeling position statement (1) that emphasized the following four general points: 1) food labeling must be truthful, meaningful, understandable, and complete; 2) no food should be designated or promoted as nutritionally good, bad, healthful, or unhealthful for people with diabetes; 3) education, based on principles of good nutrition and use of food labels, is essential for people with diabetes; and 4) specific recommendations for label inclusions.
Producing Penicillin
Authors: Phillip I. Lerner
Journal: New England Journal of Medicine (2004)

Although Alexander Fleming discovered penicillin in 1928, the substance was largely ignored until scientists at Oxford University rediscovered it in the early 1940s. Because of World War II, with its air raids and threat of German invasion, the Oxford group sought help in the United States. The meagerness of the supplies of penicillin dictated its slow evolution as a chemotherapeutic agent. Its early history involved attempts to synthesize the chemical structure and to invent ways to produce larger quantities to meet the rapidly growing demand. As more and more types of infections were found to be susceptible to penicillin, it . . .
Diagnosis of schistosomiasis
Authors: B. Zilberg
Journal: JAMA (1985)

<h3>In Reply.—</h3> In our report of an outbreak of acute<i>Schistosomiasis mansoni</i>, we refrained from suggesting that the syndrome of acute schistosomiasis also occurred with<i>S haematobium</i>because we were not convinced that infection with this species either causes or is simply coincident with the syndrome. Generally, reports of acute schistosomiasis in association with<i>S haematobium</i>infection are rare.<sup>1</sup>Typically, they concern persons suffering from a protean illness who also have<i>S haematobium</i>ova in their urine and an eosinophilia. In contrast, intense outbreaks of disease among individuals unaware of this potential problem who have had recent, brief, common-source exposures are reported for both<i>S mansoni</i>and<i>S japonicum</i>. A recent report of two cases of transverse myelitis within an outbreak of acute<i>Schistosomiasis mansoni</i>emphasizes Dr Zilberg's concern over serious manifestations of acute infection.<sup>2</sup>However, we have not had a similarly poor experience with stool or urine examination
DEATHS
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Highlights from this issue
Authors: The Triumvirate
Journal: Thorax (2020)

To celebrate the current six nations rugby tournament, this month’s Airwaves draws inspiration from the giants (literally) comprising the national teams of England, Wales, Scotland, Ireland, France and Italy. No matter which team you are rooting for there is something for everyone in this issue! Ireland won the Six Nations Championship in 2018 – a tournament marred by numerous injuries, including back injuries. This month’s pulmonary puzzle (see page 290) comes from another Irish team – from Galway University Hospitals in the West of Ireland. The authors describe unexpected pre-operative hypoxaemia in a patient with a back injury – although the individual in question was an octogenarian and a little too old for the Ireland squad. The Triumvirate don’t engage in plot spoilers but suffice to say that the diagnosis was reached with the help of echocardiography and a surgical intervention proved effective. As the 2020 Six Nations Tournament begins, let’s hope for no collapsed vertebrae. At least one of The Triumvirate will be cheering for another Irish victory! ![Graphic][1]</img> GPS tracking of the activity of individual players on the field is now widely used in elite level rugby coaching. For an in depth discussion of this topic please see: Int … [1]: /embed/inline-graphic-1.gif
Skin Reactions to Ampicillin
Authors: H. P. Lambert, F. J. Nye, H. Stern
Journal: BMJ (1972)

present the lesions become more prominent, oedematous, and brilliant in colour.2The rash is more prominent on the flanks, abdomen, shoulders, upper arms, and back and has a special predilection for the palms and soles.3There may well be associated slightly tender superficial lymphadenopathy.If these points are remembered there is little diagnostic difficulty, as the maculopa- pular eruption associated with ampicillin therapy starts most commonly on the exten- sor aspects of the limbs, especially over the knees and ankles, is uncommonly associated with any general reactions,' and, most im- portant of all, rarely occurs less than four days after the start of ampicillin therapy.5 -We are, etc.,
Abstract 2222: Long-term Outcomes of Acute Coronary Syndrome Patients with Chronic Renal Insufficiency treated with Bivalirudin vs Heparin plus a Glycoprotein IIb/IIIa Inhibitor: One Year Results from the Randomized ACUITY Trial
Authors: Roxana Mehran, Ajay J Kirtane, George D Dangas, E. M Ohman, Stuart Pocock, Bernard J Gersh, Michel E Bertrand, Martial Hamon, Steven V Manoukian, James Hoekstra, Charles V Pollack, Walter Desmet, Frederick Feit, Joseph Stella, Angel R Cequier, Thomas Stuckey, David J Cohen, Alexandra J Lansky, Gregg W Stone
Journal: Circulation (2007)

Background: In the ACUITY Trial, patients (pts) with chronic renal insufficiency (CRI) had significantly higher rates of ischemic events and major bleeding compared to pts without CRI at 30 days. Bivalirudin (Biv) monotherapy provided similar protection from ischemic events but with significantly less bleeding compared to heparin + a GPIIb/IIIa inhibitor (Hep+GPI). The impact of a Biv alone strategy on one year mortality is unknown. Methods: Pts with moderate and high risk acute coronary syndromes (ACS) were randomized to Hep + GPI, Biv + GPI, or Biv monotherapy. CRI was defined as baseline creatinine clearance (CrCl) &lt;60 mL/min. We evaluated the impact of CRI and antithrombotic strategy on composite ischemia (death, MI, or revascularization) and mortality at one year. Results: Of the pts enrolled, 12,933 had baseline CrCl data: 2468 (19.1%) pts had CrCl ≥60 mL/min and 10,465 (80.9%) pts had CrCl &lt;60 mL/min. Rates of major bleeding at 30 days in pts with CRI were significantly lower with Biv alone vs Hep+GPI (6.2% vs 9.8%, p&lt;0.01). Pts with CRI had higher mortality at one year compared to those without CRI (8.7% vs 3.0%, p&lt;0.001). There was no difference in composite ischemia for pts who received Biv monotherapy vs Hep + GPI (23.0% vs 21.4%, p=0.10). One year mortality by antithrombin strategy is shown in the Figure . Conclusions: CRI in pts with ACS is associated with higher rates of one year mortality. In these high risk pts, Biv monotherapy improved early clinical outcomes compared to Hep + GPI by reducing major bleeding, and resulted in similar rates of one year mortality. Cumulative Mortality at One Year, Patients with CRI
Renal Hemodynamic Effects of Total Cardiopulmonary Bypass Eliminating Heparinized Blood
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PAUL DUDLEY WHITE AWARDED DISTINGUISHED SERVICE MEDAL
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Philadelphia pulmonary neoplasm research project. Survival factors in bronchogenic carcinoma
Authors: W. Weiss
Journal: JAMA (1971)

During a ten-year prospective study of 6,136 men, aged 45 and older, screened every six months by 70-mm photofluorograms and questionnaires, 121 men who did not have lung cancer visible on the entry film developed lung cancer; 94 cases were proved histologically. The overall survival rate was 8% at five years. From a study of various factors in the 94 proved cases, the profile of the men most likely to survive five years includes age less than the median of 64 years, smoking one pack of cigarettes per day or less, absence of chronic cough prior to detection, a histologic type of squamous cell carcinoma or adenocarcinoma, a roentgenogram of the chest negative for cancer within 12 months before detection of the cancer, and resectability of the cancer with survival longer than 30 days after surgery.
Contents page + Editorial Board
Authors: Albert Aguayo, Tama ´s Freund, Sigismund Huck, Richard Stein, Vivian Mushahwar, Sten Grillner, Henry Markram, Erik De Schutter, Gilad Silberberg, Fiona Lebeau, Maria Toledo-Rodriguez, El Manira, Peter Walle, Gytis Svirskis, Jørn Hounsgaard, Reinoud Maex, Sten Griller, ¨rjan Ekeberg, Jeanette Kotaleski, Pablo Achard, Anders Trendsin, Sian Lewis, Heather Yeomans, Patrick Liu, Manager Moulton, A Bacci, J Huguenard, D Prince, J Stegmu, A Bonni, S Kitazawa, D Wolpert, T Schoenfeld, T Cleland, S Bouret, S Sara
Journal: Trends in Neurosciences (2005)
Omega-3 Treatment of Childhood Depression: A Controlled, Double-Blind Pilot Study
Authors: Hanah Nemets
Journal: American Journal of Psychiatry (2006)

Objective: Major depressive disorder in children may be more common than previously thought, and its therapeutics are unclear. Because of success in a previous study on omega-3 fatty acids in adult major depressive disorder, the authors planned a pilot study of omega-3 fatty acids in childhood major depression. Method: Children who entered the study were between the ages of 6 and 12. Ratings were performed at baseline and at 2, 4, 8, 12, and 16 weeks using Children's Depression Rating Scale (CDRS), Children's Depression Inventory (CDI), and Clinical Global Impression (CGI). Children were randomized to omega-3 fatty acids or placebo as pharmacologic monotherapy. Twenty-eight patients were randomized, and 20 completed at least 1 month's ratings. Results: Analysis of variance showed highly significant effects of omega-3 on symptoms using the CDRS, CDI, and CGI. Conclusions: Omega-3 fatty acids may have therapeutic benefits in childhood depression.
Nutritional Needs in Environmental Intoxication: Vitamin E and Air Pollution, An Example
Authors: D. B. Menzel
Journal: Environmental Health Perspectives (1979)

Dietary vitamin E affects the susceptibility of mice and rats to ozone and nitrogen dioxide, suggesting a free radical mechanism of toxicity. Conventional peroxidation does not completely explain the effects of alterations of lung fatty acid composition on both nitrogen dioxide and ozone toxicity. A new scheme is proposed based on the cyclization of beta, gamma-allylic peroxyl free radicals to monocyclic and bicyclic peroxides to explain the relationship between diet and toxicity. Similar results are likely with other toxicants producing peroxidation as a mechanism of toxicity. Such cyclic peroxides may mimic or interfere with the prostaglandin system. Several chronic diseases may be exacerbated through such a subtle toxic mechanism. The level of vitamin E needed for protection against peroxidation toxicity may be much greater than the present U. S. dietary intake.
A current look at the rationale of the Institute of Medicine of the National Academy of Sciences
Authors: I. H. Page
Journal: JAMA (1988)

THE INSTITUTE of Medicine (IOM) of the National Academy of Sciences (NAS) was born 18 years ago. Now that the organization is of sufficient importance to command the attention of all physicians, it merits a look at its history. This brief article is restricted to the fully documented inception of the IOM; its development is for its present members to describe and appraise. Without doubt, many people have thought of the possibility of a National Academy of Medicine (NAM), either freestanding or as part of the NAS, comparable with the National Academy of Engineers. The representation of practicing or research physicians as members of the NAS was pitifully small and scarcely representative. To test the waters for the need for an NAM, especially in view of the explosive growth of government participation in both medical practice and research, an editorial entitled "Needed: National Academy of Medicine" was published in<i>Modern</i>
Atlas and Epitome of Operative Ophthalmology.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Oxytetracycline-induced thrombocytopenic purpura
Authors: N. G. Kounis
Journal: JAMA (1975)

PURPURIC reactions resulting from the use of tetracyclines appear to be rare. Oxytetracycline-induced vascular purpura without thrombocytopenia has been reported before,<sup>1</sup>but oxytetracycline-induced thrombocytopenic purpura has not yet been widely reported. <h3>Report of a Case</h3> A 68-year-old man was admitted to Walton Hospital, complaining of fatigue, loss of appetite, mild abdominal pain, and sickness, which became evident two days before admission, and a purpuric rash covering both legs, which appeared suddenly during the night before admission. He had a mild chest infection the previous week, and the family physician had treated him with oxytetracycline tablets, 500 mg four times daily, six days before admission. No other medication had been prescribed. He had had repeated attacks of bronchitis during the last five years and had taken various antibiotics during these attacks. The last attack was one year previously. His history showed that he had been suffering from ankylosing spondylitis for
Contents
Authors: Tae-Woo Kim, Linda Zangwill, Christopher Bowd, Pamela Sample, Neha Shah, Robert Weinreb, M Leske, S Wu, R Honkanen, B Nemesure, A Schachat, L Hyman, A Hennis, Reinhard Vonthein, Stephan Rauscher, Jens Paetzold, Katarzyna Nowomiejska, Elke Krapp, Agnes Hermann, Bettina Sadowski, ´line Chaumette, John Wild, Ulrich Schiefer, Michael Wagoner, Samar Al-Swailem, John Sutphin, M Zimmerman, Nayyirih Tahzib, Rudy Nuijts, Jennifer Tan, Paul Mitchell, Wayne Smith, William Scott, Silke Schmidt, Michael Hauser, Paul Gallins, Nathalie Schnetz-Boutaud, Kylee Spencer, John Gilbert, Anita Agarwal, Eric Postel, Jonathan Haines, Margaret Pericak-Vance, U Chakravarthy, C Augood, G Bentham, M De Jong, J Rahu, G Seland, L Soubrane, F Tomazzoli, J Topouzis, J Vingerling, I Young, A Fletcher
Journal: Ophthalmology (2007)
Early Detection of the First Episode of Schizophrenia and Suicidal Behavior
Authors: Ingrid Melle
Journal: American Journal of Psychiatry (2006)

Objective: The suicide rate in schizophrenia is high, with the risk being highest early in the course. The rate of suicide attempts before treatment onset is also high and is often the event leading up to first treatment contact. A previous report showed that the duration of untreated psychosis can be reduced through an early detection program, and that the reduction was associated with lower symptom levels at treatment initiation. Treatment programs that bring first-episode patients into treatment at lower symptom levels can have the potential to reduce risk for suicide attempts. Method: The authors examined consecutive patients with nonorganic, nonaffective psychosis who sought initial treatment at psychiatric treatment units in four catchment areas: two that had an early detection program and two that did not. Results: The rate of severe suicidality (plans or attempts) was significantly higher in subjects from communities without the early detection program relative to those from early detection communities, even after adjustments for known predictors of suicidality. Conclusion: Early detection programs that bring patients into treatment at lower symptom levels may reduce suicidality risk at first treatment contact.