tbuckley/cabot-search huggingface dataset:
DANGERS FROM FORMALDEHYDE.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Points from Letters: Kilopascals
Authors: A Hollman, A F Rickards
Journal: BMJ (1975)

vogue in the future should Parliament as at present constituted beconme too unwieldy to function effectively.Moreover, the medical profession would be freer to set up and supervise what mtust surely come, and that is a body of aware persons to interview at regular intervals all persons in paid authority above a certain level of responsibility, in- cluding doctors, lawyers, M.P.s, teachers, etc., regairding their continuing suitability to hold such authority.Under the pro- fession's present subservience to politics this would be difficult to implement, if at all."What shall it profit a man if he shall gain the whole world and lose his own soul?"And as a profession we are in grave danger of doing just that.-I am, etc.,
Issue Information
Journal: Allergy (2020)

About the coverOver the past several decades, the prevalence of food allergy has con nued to increase, aff ec ng nowadays 6%-13% of the global popula on.Avoidance of allergenic foods and management of acute allergic reac ons with an histamines and epinephrine autoinjectors are the current standard of care.Allergen immunotherapy has been shown to increase the threshold of reac vity in the majority of food-allergic individuals.In this issue, Nadeau et al., in their comprehensive review, discuss the future prospects of food allergy.Kim and Burks describe food allergy treatment approaches, focusing on oral and epicutaneous immunotherapy.Gray et al. inves gate the immune profi les of food-sensi zed-tolerant infants.Furuta et al. analyze exercise-induced allergic reac ons on desensi za on to wheat a er rush oral immunotherapy.Nu en et al. characterize the physicochemical profi les of commercially available whey-and casein-based extensively hydrolyzed formula products.Hiscock et al. compare community-based model of care for simple childhood food allergy with hospital-based allergy care.Verhasselt et al. evaluate the eff ects of breas eeding on food allergy risk.Luce et al. report mul food oral immunotherapy-induced decrease of Th2/Th17 cell frequencies.Asero et al. present several cases of severe systemic reac ons following the inges on of fruits and/or vegetables occurring in pathogenesisrelated proteins group 10-and profi lin-hypersensi ve pa ents.
Tissue-specific growth suppression and chemosensitivity promotion in human hepatocellular carcinoma cells by retroviral-mediated transfer of the wild-type p53 gene
Authors: G Xu
Journal: Hepatology (1996)

Selective expression of cytotoxic gene products in tumor cells is one of the goals of gene therapy for treating cancer. We are developing such a strategy for the treatment of human hepatocellular carcinoma (HCC) by linking the wild-type p53 (WT-p53) gene with HCC-associated transcriptional control elements (TCE) to achieve selective growth inhibition of retrovirally transduced HCC cells. Replication-defective, amphotrophic retroviruses were constructed containing a WT-p53 complementary DNA (cDNA) that is transcriptionally regulated by the HCC-associated α-fetoprotein (AFP) gene TCE. Expression of exogenous WT-p53 from this retroviral vector was limited to AFP-producing cells. Introduction of WT-p53 into AFP-positive HCC cells by retroviral infection markedly inhibited their clonal growth in monolayer and soft agar cultures, and increased the sensitivity of these cells to the chemotherapeutic drug, cisplatin. Therefore, restoration of WT-p53 expression in HCC cells, in combination with chemotherapeutic drugs, can be considered as a strategy for the therapy of human liver cancer.
Antibody responses after influenza and pneumococcal immunization in HIV-infected homosexual men
Authors: K. L. Huang
Journal: JAMA (1987)

We conducted a study to assess the effect of human immunodeficiency virus (HIV) infection on humoral immunity. Fifty-five homosexual men and 19 heterosexual men had four- to six-week postimmunization antibody responses measured to trivalent influenza vaccine and 23-valent pneumococcal vaccine. The homosexual men were divided into three groups: 20 asymptomatic HIV-seronegative men, 10 asymptomatic HIV-seropositive men, and 25 HIV-seropositive men with persistent generalized lymphadenopathy. Antibody responses to influenza antigens in the subgroups of homosexual men did not significantly differ from those of heterosexual controls. The IgG antibody responses to pneumococcal capsular types 9N and 18C in men with lymphadenopathy, and type 18C in HIV-seronegative homosexual men, were lower than those of heterosexual controls. Otherwise, responses to other ten capsular types showed no significant differences. There was no evidence of an immunosuppressive effect of vaccination on T-cell numbers, or deterioration of clinical status associated with vaccination. This study demonstrates that HIV-infected homosexual men, asymptomatic or with persistent generalized lymphadenopathy, are able to mount appropriate antibody responses to two commonly used vaccines. (<i>JAMA</i>1987;257:2047-2050)
Obstacles predicting lack of a regular provider and delays in seeking care for patients at an urban public hospital
Authors: K. J. Rask
Journal: JAMA (1994)

<h3>Objective.</h3> —To determine the correlation among obstacles to medical care, lack of a regular source of care, and delays in seeking care. <h3>Design.</h3> —Cross-sectional survey of patients presenting for ambulatory care during a 7-day period. Multiple logistic regression models were used to identify obstacles independently associated with outcome variables. <h3>Setting.</h3> —Urban public hospital. <h3>Patients.</h3> —A total of 3897 disadvantaged and predominantly minority patients. <h3>Main Outcome Measures.</h3> —Lack of a regular source of medical care and delay in seeking medical care for a new problem. <h3>Results.</h3> —The majority (61.6%) of patients reported no regular source of care. Of 2341 patients reporting a new medical problem, 48.4% waited more than 2 days before seeking medical care. No health insurance (adjusted odds ratio [OR], 2.2; 95% confidence interval [CI], 1.89 to 2.61), no transportation (OR, 1.44; 95% CI, 1.23 to 1.70), exposure to violence (OR, 1.21; 95% CI, 1.08 to 1.45), and living in a supervised setting (OR, 1.50; 95% CI, 1.00 to 2.25) were independent predictors of lack of a regular source of care. No insurance (OR, 1.24; 95% CI, 1.02 to 1.51), no transportation (OR, 1.45; 95% CI, 1.19 to 1.77), and less than a high school education (OR, 1.22; 95% CI, 1.08 to 1.49) were independent predictors of delaying care for a new medical problem. <h3>Conclusions.</h3> —Obstacles in addition to lack of insurance impede provision of medical care to disadvantaged patients. The adoption of universal health care coverage alone will not guarantee access to appropriate medical care. (<i>JAMA</i>. 1994;271:1931-1933)
Abstract 4016: PIK3IP1 regulates prostate cancer cell migration and proliferation and is a noninvasive biomarker of the disease
Authors: Andrej Jedinak, Katherine Kaplan, Kevin Loughlin, Marsha Moses
Journal: Cancer Research (2019)

Abstract Prostate cancer (PCa) is the second most common epithelial cancer in men after lung cancer. PCa shares similar clinical symptoms with benign prostate hyperplasia (BPH) making it very challenging for physicians to make an accurate diagnosis. Prostate specific antigen (PSA) has been used for several decades to facilitate clinical decision making but unfortunately lacks sensitivity and specificity and cannot effectively distinguish between these two prostate diseases. Therefore, there is a need for new biomarkers that can discriminate between these two diseases with high accuracy. Using a global proteomics approach supported by extensive validation, we have found significantly (P&amp;lt;0.002) elevated levels of Phosphoinositide-3-Kinase Interacting Protein1 (PIK3IP1) in the urine of PCa patients with early disease compared to patients with BPH. These data motivated us to examine the potential role of this protein in prostate cancer development and progression. We began by transiently transfecting multiple prostate cancer cell lines including DU145, PC-3 and LNCaP with a PIK3IP1 plasmid DNA and used these cells to conduct proliferation and migration studies in vitro. We found that there was a significant inhibition of PCa cell proliferation (P&amp;lt;0.05) and migration (P&amp;lt;0.007) in all cell lines tested. We validated these finding with DU145 stable clones established by lentiviral transduction with a PIK3IP1 vector. Stable clones overexpressing PIK3IP1 significantly suppressed proliferation and especially migration and invasion of DU145 cells. We next transiently transfected DU145, PC-3 and LNCaP cells with PIK3IP1 plasmid DNA and performed phospho-protein array experiments to identify signaling molecules that might be modulated by PIK3IP1 to mediate these activities. These data revealed altered levels of molecules involved in several pathways including MAPK. We are currently conducting further in vitro and in vivo studies to assess the potential effects of PIK3IP1 on the modulation of prostate cancer progression and metastasis. In summary, we have identified and validated the urinary detection of PIK3IP1 as a novel liquid biopsy biomarker for localized PCa and have demonstrated that it can modulate both the migration and proliferation of several PCa cells including DU145, PC-3 and LNCaP. (Supported by The Ellison Foundation and the Advanced Medical Research Foundation) Note: This abstract was not presented at the meeting. Citation Format: Andrej Jedinak, Katherine Kaplan, Kevin Loughlin, Marsha Moses. PIK3IP1 regulates prostate cancer cell migration and proliferation and is a noninvasive biomarker of the disease [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4016.
Antenatal Prediction of Hemolytic Disease of Newborn
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Comma Error in Table Values
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Enough about AIDS: another letter about AIDS
Authors: R. H. Kubin
Journal: JAMA (1989)

<h3>In Reply. —</h3> Drs Clark and Ginsberg appropriately call me to task for failing to mention family physicians as likely people to provide primary AIDS care. Indeed, many of the skills needed in caring for patients with AIDS are ones used daily by such practitioners. However, in contrast to Dr Dolan, I am not optimistic that family practice, any more than general internal medicine, offers a totally appropriate model for primary care of patients throughout the spectrum of HIV infection. Thus, I still believe that with time, a separate AIDS specialty may well evolve. Such a specialty ideally would incorporate many of the attributes of family practice mentioned by Dr Dolan as well as draw on knowledge of the medical subspecialties, public health, epidemiology, law, and ethics. Finally, I agree with Dr Zelicoff that among the many barriers to physician recruitment in AIDS, deficiencies of reimbursement to physicians providing such
Metabolomics, Proteomics, Genomics, and Transcriptomics in <i>Circulation</i> and the <i>Circulation</i> Subspecialty Journals
Journal: Circulation (2012)

The following articles are being highlighted as part of Circulation's Topic Review series. This series will summarize the most important manuscripts, as selected by the editors, published in Circulation and the Circulation subspecialty journals. The studies included in this article represent the articles related to metabolomics, proteomics, genomics, and transcriptomics that were published in Circulation and the Circulation subspecialty journals in 2010, 2011, and early 2012.
Transverse myelitis and heroin addiction.
Journal: BMJ (1969)

lines of the late Board of Control should be appointed without delay.5But, above all, there must be immediate attention given to the improvement of the staffing structure of nurses, doctors, and ancillary workers, and every inducement given by whatever means to improve recruitment.Cinderella can be transformed, but to turn a kitchen slut into a princess costs a lot of money.The money can and must be found if a once splendid service is itself to be rehabilitated.
Thrombopoietin
Authors: Kenneth Kaushansky
Journal: New England Journal of Medicine (1998)

Although the cellular physiology of megakaryocyte and platelet production has been understood for nearly a decade, the humoral basis of this process has remained enigmatic until recently. “Thrombopoietin — At Last” heralded one editorial1 when the cloning of the chief regulator of megakaryocyte and platelet production was reported.24 The availability of the purified hormone has made possible new insights into many aspects of blood-cell development and provided a way to increase platelet production in patients with bone marrow failure. This review focuses on the physiology of thrombopoietin and megakaryocyte production, with a view to understanding how this information can . . .
A prospective analysis of quality of life (QoL), cognitive functions (CF) and psychological status (PSY) in glioblastoma (GBM) patients (PTS) treated with RT and temozolomide (TMZ)
Authors: E. Bergo, G. Lombardi, P. Del Bianco, F. Berti, L. Bellu, A. Pambuku, V. Zagonel
Journal: Annals of Oncology (2016)
Hepatic and Extrahepatic Metabolism of 14 C-Styrene Oxide
Authors: Adrian J. Ryan, Margaret O. James, Zvi Ben-Zvi, Francis C. P. Law, John R. Bend
Journal: Environmental Health Perspectives (1976)

With 8-'C-styrene oxide as substrate, specific glutathione S-transferase and epoxide hydrase activities were determined in subcellular fractions of liver, lungs, kidney, and intestinal mucosa from rabbit, rat, and guinea pig.Liver had the highest enzyme activities in each species.Rat and guinea pig had higher glutathione S-transferase activity in both liver and kidney than rabbit.Rat testis also had appreciable glutathione S-trans.ferase activity.The perinatal development of epoxide hydrase and glutathione S-transferase was followed in liver and several extrahepatic tissues of fetal and neonatal guinea pigs and rabbits.The rates at which enzyme activities reached adult levels in the extrahepatic tissues differed from the liver in both species.Epoxide hydrase and glutathione S-trans- ferases developed at different rates in each organ, demonstrating that the relative im- portance of these two detoxifying pathways for styrene oxide may shift before and after birth.The effects of pretreating male and female rats with phenobarbital (PB), 1,2,3,4- dibenzanthracene (DBA), pregnenolone-16a-carbonitrile (PCN), or 2,3,7,8-tetrachloro- dibenzo-p-dioxin (TCDD) on hepatic and extrahepatic epoxide hydrase and glutathione S-transferase activities toward styrene oxide were determined.PB increased both enzyme activities in liver of both sexes.PCN induced only glutathione S-transferase activity in female liver.Extrahepatic epoxide hydrase and glutathione S-transferase activities were unaffected except that TCDD doubled female renal epoxide hydrase activity and PB in- creased intestinal epoxide hydrase activity in both sexes.Styrene oxide biotransformation was studied in isolated, perfused rat liver and rabbit lung preparations.Conjugation with glutathione was a major metabolic pathway although significant amounts of diol were also formed in each instance.In rat liver, 27-40% of the administered styrene oxide was excreted via the bile mainly as S-(1-phenyl-2hydroxyethyl) glutathione.
Improving quality of health-related quality of life (HRQOL) reporting in phase III randomized controlled trials (RCTs) of metastatic urothelial carcinoma (mUC).
Authors: Di Maria Jiang, Bryan Wong, Joaquim Bellmunt, Thomas Powles, Alicia K. Morgans, David J. Vaughn, Srikala S. Sridhar
Journal: Journal of Clinical Oncology (2020)

467 Background: HRQOL data are increasingly used to guide patient care and health policy. However, their utility can be compromised by inadequate quality of HRQOL reporting (QHR). We aimed to systematically evaluate QHR in phase III RCTs of mUC. Methods: A comprehensive systematic review following PRISMA guidelines identified published manuscripts of phase III RCTs of mUC in English between 1985 - 2019. Supplementary material, references and companion publications were reviewed. QHR was quantified using: 1) 2013 CONSORT-PRO extension (CPE), and 2) 2003 Minimum Standard Checklist for Evaluating HRQOL Outcomes in Cancer Clinical Trials (MSC). Both scores range from 0-11, with higher scores indicating higher QHR. QHR is “probably robust” if MSC score is ≥8 and all 3 mandatory items (baseline compliance, missing data, and psychometric properties) are reported; “limited” if MSC score is 5-7; and “very limited” if MSC score is ≤4. Results: HRQOL data was collected in 7/21 (33%) mUC phase III RCTs. All reported HRQOL data as secondary/exploratory endpoints. Generic instruments included EORTC QLQ-C30 alone (n=3) or combined with EQ-5D (n=2)/McGill pain questionnaire (n=1). Disease-specific FACT-Bl was used in 1 RCT. Both checklists showed strong correlation (Spearman coefficient 0.94, p=0.001). QHR was often limited, however has improved in recent years (Table). No RCT stated HRQOL-specific hypotheses. Only 1 reported instrument validity and mode of administration. Few provided domain specific results (n=2) and statistical methods for handling missing data (n=3). Implications for clinical practice were only discussed in 3 RCTs. Conclusions: QHR has improved over time however many critical methodological deficiencies remain in mUC phase III RCTs. The use of standard checklists are encouraged to further enhance QHR and promote high quality HRQOL research. [Table: see text]
Bone Marrow Biopsy: Hæmatology in the Light of Sternal Puncture
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Commentaire de travail de J. W. Tischendorf et al., pp. 1092
Journal: Endoscopy (2007)

See also: Value of magnifying chromoendoscopy and narrow band imaging (NBI) in classifying colorectal polyps: a prospective controlled studyEndoscopy 2007; 39(12): 1092-1096DOI: 10.1055/s-2007-966781
Medicaid Eligibility, Prenatal Care, and the Outcome of Pregnancy-Reply
Authors: Bernard Guyer
Journal: JAMA (1991)

<h3>In Reply. —</h3> Dr Jameson raises an important issue but reaches the wrong conclusion. "Policymakers in government, public health, and medicine" recognize that maternal behavior influences birth outcome.<sup>1</sup>In fact, the recent report of the Expert Panel on the Content of Prenatal Care<sup>2</sup>outlines a comprehensive program directed at identifying and addressing these risk factors. The interventions can only be applied, however, if women who are poor have the same access to health care as their middle-class contemporaries. The Medicaid eligibility expansions were intended by Congress to assure such access. Blaming the women who engage in these high-risk behaviors and preventing them from accessing services can hardly be expected to improve their outcomes. I agree with Dr Moore's diagnosis that the fragmented and overly complex nature of our health care system contributes to the adverse perinatal outcomes among low-income women. He provides a brief description of an innovative