tbuckley/cabot-search huggingface dataset:
Association of colorectal cancer intrinsic subtypes with prognosis, chemotherapy response, deficient mismatch repair, and epithelial to mesenchymal transition (EMT).
Authors: Iris Simon, Paul Roepman, Andreas Schlicker, Josep Tabernero, Ian Majewski, Victor Moreno Aguado, Christine M Chresta, Robert Rosenberg, Ulrich Nitsche, Teresa Macarulla, Gabriel Capella, Ramon Salazar, George Orphanides, Lodewyk F A Wessels, Rene Bernards
Journal: Journal of Clinical Oncology (2013)

333 Background: Unbiased genome-wide analyses of gene expression patterns have been successfully used for the molecular classification of breast cancer into subtypes that have clear relevance for prognosis and development of treatment plans. For colorectal cancer (CRC), however, a molecular classification is still missing. Methods: Using gene expression data of 188 stage I-IV colorectal cancer (CRC) patients, a molecular subtype classification was developed. The classifier was validated in 543 stage II and III patients and the subtypes were analyzed for correlation to clinical information, mutations in the kinome, known molecular marker status and chemotherapy response. Results: CRC is a heterogeneous disease that consists of at least three major intrinsic subtypes (A-, B-, C-type). The heterogeneity of the intrinsic subtypes is largely based on three biological hallmarks of the tumor: an epithelial-to-mesenchymal transition, deficiency in mismatch repair genes that result in a high mutation frequency associated with MSI, and cellular proliferation. C-type patients have the worst outcome, a mesenchymal gene expression phenotype, and show no benefit from adjuvant chemotherapy treatment. Patients having A-type or B-type tumors have a better clinical outcome, a more proliferative and epithelial phenotype, and benefit from adjuvant chemotherapy. B-type tumors showed a low overall kinome mutation frequency (1.6%), while both A-type and C-type patients harbor a higher mutation frequency (respectively 4.2 and 6.2%), in agreement with their mismatch repair deficiency. Conclusions: We have developed a diagnostic single sample predictor that allows the classification of CRC tumors of different intrinsic molecular subtypes. These subtypes are potentially clinically relevant, as they differ in their underlying biology and clinical outcome and consequently require different treatment strategies. [Table: see text]
Modification of Biological Surface Activity of Particles
Authors: R. J. Schnitzer
Journal: Environmental Health Perspectives (1974)

The hemolytic activity of fibrous asbestos varieties and of fibrous or granular silica dust can be markedly reduced by adsorption of polymers. Polyanions exert a specific action on asbestos, particularly chrysotile, whereas silica is inactivated by nonionic polymers. A high degree of reduction of the lytic action by comparatively small amounts of the antagonistic polymers can be demonstrated after short exposure to concentrations of 0.1–0.4 mg/ml of appropriate polymers. Inactivation is based on stable adsorption. Repeated washings of inactivated mineral sediments or exposure to elevated temperatures (80–120°C) produced no essential loss of the reduction of lytic potency. In one example, inactivation of chrysotile by sodium alginate, depolymerization by ascorbic acid was also ineffective.
Wednesday, November 2, 1983
Authors: Joel Glaser, Joseph Mauriello, Joseph Flanagan, Robert Peyster, A Discussion, J Earl Rathbun, Santa Rosa, Maxillectomy Smith, Richard Lisman, Daniel Baker, New York, A Berlin, Kevin Charlton, Branson Call, Michael Limburg, New Orleans, Gary Stanford, A Williams, Salt Lake, Burton Kushner, Anne Drysdale, P Fitzpatrick, Michael Easterbrook, P Discussion, Bartley Frueh, Ann Arbor, Mark Levine, Arthur Grove, Stanley Truhlsen, Omaha Ne, Jerome Bettman, Malcolm Mccannel, Homer Smith, Robert Christensen, Los Angeles, George Beauchamp, John Hibbs, Ralph Kirsch
Journal: Ophthalmology (1983)
Replacement of Segments of the Venous System
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Routine Treatment for Diabetic Ketoacidosis
Journal: JAMA (1973)

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Miscellany
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Leonard's Physicians' Pocket Day-Book.
Journal: JAMA (1892)

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Table of Contents
Authors: David Harris, Simon Davies, Fredric Finkelstein, Vivekanand Jha, Aminu Bello, Mark Brown, Fergus Caskey, Jo-Ann Donner, Adrian Liew, Elmi Muller, Saraladevi Naicker, Philip O'connell, Roberto Filho, Tushar Vachharajani
Journal: Kidney International (2020)
Changes in c-onc Expression during Embryonal Carcinoma Cell Differentiation
Authors: Thomas Sejersen, Pei Jin, Magnus Rahm, Nils R. Ringertz
Journal: Environmental Health Perspectives (1989)

Protooncogenes expressed in murine embryonal carcinoma (EC) cells or their differentiated daughter cells include more or less ubiquitously expressed protooncogenes such as c-myc, c-K-ras, and c-abl, as well as c-onc genes with a very restricted expression pattern. Examples of the latter are N-myc, c-mos, and int-2. These c-onc genes are transcriptionally active in EC cells, as well as in germ cells and/or early embryonic cells. When EC cells are induced to differentiate some protooncogenes or oncogene-related products undergo changes in expression. Thus, EC cell differentiation has been associated with increased expression of c-src, c-fos, int-1, int-2, and the epidermal growth factor (EGF) receptor, whereas decreased expression has been observed for c-mos, c-K-ras, c-myc, N-myc, and platelet-derived growth factor. The relationships between these changes in expression and EC cell differentiation are not understood. They may be important for the differentiation process or for expression of a differentiated phenotype. They may, however, also be secondary events with no functional significance to EC cell differentiation.
Cooperation not confrontation: the imperative of a nuclear age. The message from Budapest
Authors: B. Lown
Journal: JAMA (1985)

WE GATHER once again, a fifth time in less than five years, for the annual Congress of the International Physicians for the Prevention of Nuclear War, the IPPNW. We come here determined to ward off the greatest pestilence threatening life. We meet in a city, risen from the rubble of conventional war, once again beautiful and cultivated. We convene in a country that has suffered misery, plunder, starvation, and death with nearly 10% of its people killed in World War II. Our Hungarian colleagues therefore understand the meaning of nuclear war. They have worked with perseverance to make this Congress a memorable event. We commend Academician Susan Hollán for leadership and commitment. We acknowledge with respect and gratitude the tireless efforts of Drs Gyözö Petrányi, László Sztanyik, Csaba Farsang, Anna Romany, János Gergely, Csaba Láng, Balázs Sarkadi, and many other contributors deserving praise. <h3>Two Anniversaries</h3> We gather under the slogan,
GOVERNMENT SERVICES
Journal: JAMA (1960)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Intentions to communicate positive HIV-antibody status to sex partners
Authors: S. M. Kegeles
Journal: JAMA (1988)

<h3>To the Editor.</h3> —I would like to commend Horsburgh et al<sup>1</sup>on their article entitled "Preventive Strategies in Sexually Transmitted Diseases for the Primary Care Physician" in the Aug 14 issue ofThe Journal. I would like to mention, however, that topical treatment with erythromycin and tetracycline is not definitely effective in preventing chlamydial conjunctivitis. It was interesting to note in their article that the recommendation to use erythromycin eye ointment for prevention of ophthalmia neonatorum by<i>Chlamydia trachomatis</i>received the highest recommendation based on one study performed by Hammerschlag et al.<sup>2</sup>Hammerschlag and colleagues recently repeated a prospective study to evaluate erythromycin, tetracycline, and silver nitrate drops for the prevention of chlamydial conjunctivitis in a somewhat larger population than in their original study. Of 118 infants born to<i>Chlamydia</i>-positive women, 11% who received silver nitrate, 13% who received erythromycin ointment, and 16% who received tetracycline ointment
1215 PRECLINICAL CHARACTERIZATION OF THE HEPATITIS C VIRUS NS5B POLYMERASE NON-NUCLEOSIDE INHIBITOR BILB 1941
Authors: G. Kukolj, P.C. Anderson, M. Boes, M.G. Cordingley, R. Coulombe, M. Garneau, J. Gillard, S. Goulet, E. Jolicoeur, L. Lagacé, D. Lamarre, S. Laplante, M. Marquis, G. McKercher, C. Pellerin, M.-A. Poupart, P.L. Beaulieu
Journal: Journal of Hepatology (2011)
What's in a name?
Authors: None The Lancet Psychiatry
Journal: The Lancet Psychiatry (2018)

In 1975, The Lancet contended that, in the naming of diseases, "The possessive use of an eponym should be discontinued, since the author neither had nor owned the disorder." More than 40 years later, we are discovering another reason to avoid the practice. The recent revelation of Hans Asperger's complicity with the Nazi regime has shocked many, and has raised numerous questions about his practice and about how details of his life did not come to light before now. Herwig Czech's article, published in Molecular Autism, revealed astonishing truths about Asperger drawn from archives of personnel files, political assessments, and medical case records from the Am Spiegelgrund clinic, which was known for its child euthanasia programme.
Date of delivery in multifetal pregnancies
Authors: B. Luke
Journal: JAMA (1996)

<h3>In Reply.</h3> —We agree with Dr Luke that our proposal has limited applicability in the United States. The mean duration of pregnancies may be influenced by racial factors.<sup>1</sup>Maternal height is positively correlated with duration of pregnancy,<sup>2</sup>and maternal body mass index may also be positively correlated with gestational length.<sup>3</sup>Japanese women are shorter and slimmer compared with white American women. Thus, the mean duration of pregnancy among white American women may be longer than that among Japanese women. However, as pointed out by Luke, pregnancy with twins is different from that involving triplets or higher-order pregnancy. Twin pregnancy is apparently different biologically from singleton pregnancy, regardless of race, with respect to the duration of pregnancy, as suggested by our study. The problem is that the definition of term delivery, which may have been derived from populations in which singleton pregnancies accounted for more than 95% of all pregnancies,
Return to work after stroke
Authors: R. J. Joynt
Journal: JAMA (1985)

Prognostication in medicine is one of our duties, but it is one that we all undertake remembering our many mistakes in the past. We become guarded and finally grudgingly accept that we cannot outguess the capricious nature of disease. So in many instances we beg off when pressed by patients and relatives, and in many instances our professed ignorance may not be a major consequence in the care. This is not the situation in certain disorders in which prognosis is an essential key in selecting patients for treatment programs and advising patients and their families about the possibilities for future employment. One of the areas where this is particularly important is that of patients who have brain damage from strokes. The recovery from a cerebral infarction is usually slow and usually unpredictable. In this issue of<i>JAMA</i>, Howard and co-workers1 carefully considered factors influencing the return to work in this
THE EFFECT OF THE DANYZ VIRUS ON RATS.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Investigators widen inquiry into percutaneous angioplasty application
Authors: K. Simmons
Journal: JAMA (1984)

Questions and answers continue to fly regarding the use of percutaneous transluminal coronary angioplasty (PTCA). One recent occasion was a session at the meeting of the American College of Chest Physicians in Chicago. Since, as Ronald E. Vlietstra, MB, ChB, noted, "most patients with symptomatic coronary disease have stenosis in more than one vessel," the question of treating multivessel disease arose. Vlietstra said that in an ongoing study (the first report of which appeared in<i>Mayo Clinic Proceedings</i>[1983;58:563-567]), his research group at the Mayo Clinic is examining the effectiveness—in terms of both success and safety—of PTCA for this purpose. Vlietstra, an associate professor of medicine at the Mayo Medical School, defined multivessel disease as 70% or greater stenosis in at least one major epicardial vessel, as well as 50% or greater stenosis in at least one other major vessel. Single vessel disease is defined by the first condition alone.
Ankylosing spondylitis and hyperparathyroidism
Authors: R. Goldin
Journal: JAMA (1978)

An attempt was made to determine whether a relationship exists between ankylosing spondylitis (AS) and hyperparathyroidism (HP). Twenty patients with definite AS, studied for biochemical evidence of HP, did not show consistent abnormalities in serum calcium, phosphorus, alkaline phosphatase, or parathyroid hormone levels or in bone-density measurements. Reviewing roentgenograms of 39 patients with HP showed one patient with sacroiliitis, and one of the 28 hyperparathyroid patients tissue-typed as HLA B27-positive. Both AS and HP are independent entities that have no causative or pathological relationship to each other. (<i>JAMA</i>240:759-761, 1978)
Golden Weekend
Authors: Jessica Giacinto Lawrence
Journal: Annals of Internal Medicine (2015)

Ad Libitum1 September 2015Golden WeekendJessica Giacinto Lawrence, MDJessica Giacinto Lawrence, MDFrom Manhasset, New York.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M15-1332 Audio Reading - “Golden Weekend” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Golden Weekend," by J.G. Lawrence. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The kids play in the yardTrying to get a kite in the air;It won't fly, but they sure have fun trying.Birds chatter on a bush by the fence.I wander over to investigate.Bulbs of luscious ocean blueDangle from the branches.It's summertime in New York.I take one and gently pull it off with a snap.I close my eyes and taste,The sweet crisp explosion, the essence of summer cool.The warm breeze blows,The air is filled with children's laughter.BEEP BEEP BEEPMy pager quivers and pulls me away from my midsummer night's dream.“Medicine, returning a page.”Jessica Giacinto Lawrence, MDManhasset, New York Author, Article, and Disclosure InformationAffiliations: From Manhasset, New York.Current Author Address: Jessica Giacinto Lawrence, MD, 300 Community Drive, Manhasset, NY 11030; e-mail, jessica.[email protected]com. PreviousarticleNextarticle Advertisement Audio Reading - “Golden Weekend” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Golden Weekend," by J.G. Lawrence. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 1 September 2015Volume 163, Issue 5Page: 346KeywordsChildrenTaste ePublished: 1 September 2015 Issue Published: 1 September 2015 Copyright & PermissionsCopyright © 2015 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Neurosurgical Techniques
Authors: Oscar Sugar
Journal: JAMA (1964)

Among the unique features of this book, intended for medical students, general surgeons, and trainees and practitioners of neurosurgery, is a historical review starting with Cushing and Dandy, and ending with Inca trephining. Other items of historical interest are contained in the text, which summarizes classical accounts of various operations on the nervous system. These accounts supplement the descriptions of Asenjo's own operative techniques, as well as those of some of his 20 collaborators. The latter have also contributed chapters on ancillary techniques (of ophthalmology, otology, radiology, isotope scanning, and neurophysiological research). The instruments and their detailed physical layout, as used in the daily work of the Neurosurgical Institute in Santiago, Chile, are described for the benefit of those who might come into a virgin neurosurgical territory. Also discussed are preoperative preparation of the patient, positions on the table, opening and closing wounds, control of bleeding, various approaches to the