tbuckley/cabot-search huggingface dataset:
PARIS
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract P197: Structural and Functional Arterial Changes in Healthy Women Following Pregnancy
Authors: Mansi Desai, Nancy Niemczyk, Janet Catov, Marnie Bertolet, Emma Barinas-Mitchell, Mindy Columbus
Journal: Circulation (2016)

Background: Parity is associated with future maternal cardiovascular disease (CVD) risk in a J-shaped fashion. Markers of vascular aging and future CVD risk, such as common carotid artery intima-media thickness (CCA IMT) and inter-adventitial diameter (IAD), increase acutely during pregnancy. As reported previously, increased CCA IMT did not recede in the early postpartum period. This study aims to determine whether vascular changes during pregnancy persist beyond the initial postpartum period. Methods: This study is a follow-up to a prospective study that assessed vascular health in a cohort of 43 healthy women during a first pregnancy and at 6-8 weeks postpartum. Data on physical measures, biomarker assays, pregnancy outcomes, health history and CCA IMT and IAD via B-mode ultrasound were collected at a second post-partum visit 1-5 years following the index birth. Paired t-tests and multivariable linear regression were used to assess changes in vascular measures. Results: Sixteen participants with mean±SD age 32.4±4.4 years, BMI 25.6±3.1 kg/m 2 , cumulative breastfeeding time of 19.7±11.2 months and time from index delivery of 2.7±0.8 years completed the second postpartum visit. Eight of these women had ≥ 1 subsequent births. Compared to the third trimester, the decrease in IAD and increase in IMT observed early postpartum, persisted further out postpartum (figure). At the second postpartum visit, larger IAD was associated with higher blood pressure whereas thicker IMT was associated with less time since index birth, greater weight gain, shorter duration of breastfeeding, and lower insulin resistance (all p&lt;0.05). Conclusions: Markers of vascular aging did not consistently improve 1 to 5 years after delivery. Persistence of pregnancy related vascular effects suggest a possible mechanism linking increased CVD risk with parity. Prolonged breastfeeding and weight management following pregnancy may be modifiable lifestyle factors affecting future maternal CVD risk.
News and Notices
Journal: British Journal of Dermatology (1993)

British Journal of DermatologyVolume 128, Issue 6 p. 711-711 News and Notices First published: June 1993 https://doi.org/10.1111/j.1365-2133.1993.tb00281.xAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume128, Issue6June 1993Pages 711-711 RelatedInformation
CONSUMPTION NOT THE ONLY PROBLEM.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE VALUE OF THYROID EXTRACT.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ACTR-64. OBJECTIVE RESPONSES TO CHEMOTHERAPY IN RECURRENT GLIOMA DO NOT PREDICT BETTER SURVIVAL: A PROSPECTIVE ANALYSIS FROM THE GERMAN GLIOMA NETWORK
Authors: Oliver Baehr, Bettina Hentschel, Elke Hattingen, Matthias Reusche, Marcos Tatagiba, Jörg-Christian Tonn, Oliver Schnell, Gabriele Schackert, Manfred Westphal, Ulrich Herrlinger, Thorsten Pietsch, Guido Reifenberger, Michael Weller, Markus Löffler, Joachim Steinbach
Journal: Neuro-Oncology (2018)

Outside of clinical trials, the occurrence of objective responses (OR) to chemotherapy in patients with recurrent gliomas is poorly characterized. Further, the predictive value of OR for PFS and OS is unclear. We screened the German Glioma Network Database for patients who had received chemotherapy only for recurrent glioma. As PFS was not available for a large number of patients we used the composite endpoint time-to-treatment-failure (progressive disease, start of a new therapy or death). We included 485 patients who received 646 chemotherapy regimens for treatment of recurrent glioma. Of these, only 32 chemotherapies in 32 patients resulted in an OR (30 PR, 2 CR) after central review according to RANO criteria. OR rates were 2.8%, 11.0% and 10.6% for glioblastoma, anaplastic glioma WHO grade III and diffuse glioma WHO grade II, respectively. Temozolomide (n=232) resulted in ORs in 7.8% of the patients, while nitrosourea (n=212) and imatinib (n=27) resulted in ORs in 6.1% and 3.7%, respectively. Overall, responders showed a significantly improved OS compared to non-responders (median OS 33.3 versus 15 months, p=0.054). Yet, a Cox regression analysis adjusted for diagnosis and age did not reveal a significant association of objective responses with overall survival (relative risk 0.8, p=0.391). In addition, we generated a 1:3 cohort (n=96) of non-responders matched for diagnosis. There was no relevant difference in OS comparing responders to the matched cohort (median OS 33.3 versus 25.6 months, p=0.929). When comparing non-responders with longer time-to-treatment-failure (>14 weeks, assumed stable disease as best response) with responders (n=32) the difference in outcome was lost (median OS 24.3 versus 33.3 months, p=0.86). In this prospective trial ORs to chemotherapy in the recurrent setting were rare. Notably, when comparing responders with a matched cohort or patients with assumed stable disease as best response, ORs were not associated with improved survival.
Highlights
Journal: JAMA Neurology (2016)

Pharmacotherapy for Pain in Inherited Erythromelalgia 659Geha and colleagues determine whether pain in inherited erythromelalgia can be attenuated via pharmacotherapy guided by genomic analysis and functional profi ling.The main outcomes and measures were behavioral assessment of pain, functional magnetic resonance imaging, and assessment of fi ring in dorsal root ganglion neurons carrying S241T mutant channels.Their results demonstrate that pharmacotherapy guided by genomic analysis, molecular modeling, and functional profi ling can attenuate neuropathic pain in patients carrying the S241T mutation.
HGF, SDF-1, and MMP-9 are involved in stress-induced human CD34+ stem cell recruitment to the liver
Authors: Orit Kollet, Shoham Shivtiel, Yuan-Qing Chen, Jenny Suriawinata, Swan N. Thung, Mariana D. Dabeva, Joy Kahn, Asaf Spiegel, Ayelet Dar, Sarit Samira, Polina Goichberg, Alexander Kalinkovich, Fernando Arenzana-Seisdedos, Arnon Nagler, Izhar Hardan, Michel Revel, David A. Shafritz, Tsvee Lapidot
Journal: Journal of Clinical Investigation (2003)

Hematopoietic stem cells rarely contribute to hepatic regeneration, however, the mechanisms governing their homing to the liver, which is a crucial first step, are poorly understood. The chemokine stromal cell–derived factor-1 (SDF-1), which attracts human and murine progenitors, is expressed by liver bile duct epithelium. Neutralization of the SDF-1 receptor CXCR4 abolished homing and engraftment of the murine liver by human CD34+ hematopoietic progenitors, while local injection of human SDF-1 increased their homing. Engrafted human cells were localized in clusters surrounding the bile ducts, in close proximity to SDF-1–expressing epithelial cells, and differentiated into albumin-producing cells. Irradiation or inflammation increased SDF-1 levels and hepatic injury induced MMP-9 activity, leading to both increased CXCR4 expression and SDF-1–mediated recruitment of hematopoietic progenitors to the liver. Unexpectedly, HGF, which is increased following liver injury, promoted protrusion formation, CXCR4 upregulation, and SDF-1–mediated directional migration by human CD34+ progenitors, and synergized with stem cell factor. Thus, stress-induced signals, such as increased expression of SDF-1, MMP-9, and HGF, recruit human CD34+ progenitors with hematopoietic and/or hepatic-like potential to the liver of NOD/SCID mice. Our results suggest the potential of hematopoietic CD34+/CXCR4+cells to respond to stress signals from nonhematopoietic injured organs as an important mechanism for tissue targeting and repair.
HIV-Related Beliefs, Knowledge, and Behaviors Among High School Students
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bacterial Sepsis Associated With Receipt of Albumin
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 14347: Septal Myectomy is Associated With Worse In-Hospital Outcomes than Alcohol Septal Ablation: Data From the Nationwide Inpatient Sample in the United States, 2003-2011
Authors: Patrick M Looser, Rajesh V Swaminathan, Robert M Minutello, S. C Wong, Geoffrey Bergman, Harsimran Singh, Chris Gade, Konstantinos Charitakis, Ryan K Kaple, Dmitriy N Feldman, Luke K Kim
Journal: Circulation (2015)

Introduction: Septal myectomy (SM) and alcohol septal ablation (ASA) are performed for treatment of obstructive hypertrophic cardiomyopathy (HCM). Previous studies comparing ASA and SM are limited to single center registries. We aimed to compare in-hospital outcomes after ASA and SM within a large, national inpatient database. Hypothesis: SM is associated with worse in-hospital outcomes than ASA, particularly in low volume centers. Methods: We analyzed all patients who were hospitalized for ASA (n=6,386) or SM (n=4,862) in the Nationwide Inpatient Database from 2003 to 2011. Rates of adverse in-hospital events (death, stroke, bleeding, acute renal failure (ARF) and need for permanent pacemaker (PPM)) were examined. Multivariate adjusted analysis was performed to compare outcomes based on tertiles of hospital volume. Results: Patients undergoing SM were younger, more likely to be female, have anemia, chronic pulmonary disease, diabetes with complications, obesity, peripheral vascular disease and coagulopathy. The incidence of in-hospital death (5.2% vs. 0.7%), post-procedural stroke (1.8% vs. 0%) and ARF (9.7% vs. 3.3%) were greater in SM vs. ASA groups, respectively (all p&lt;0.001). After adjustment for baseline differences and confounders using multivariate propensity-score adjusted logistic regression analysis, SM remained an independent predictor of in-hospital death (OR 5.59, 95%CI 3.71-8.43), stroke (OR 3.81, 95% CI 2.06-7.07) and ARF (OR 2.23, 95% CI 1.77-2.90). In addition, low hospital volume of SM was an independent predictor of mortality (adj OR 3.11, 95% CI 1.98-4.89) and bleeding (adj OR 3.77, 95% CI 2.12-6.70), while low volume of ASA was not independently associated with an increased risk of adverse post-procedural events. Conclusions: In conclusion, SM was associated with worse in-hospital outcomes, including death, stroke and acute renal failure. Low volume status is associated with worse in-hospital outcomes for SM but not for ASA.
Health Status of Cambodians and Vietnamese—Selected Communities, United States, 2001-2002
Journal: JAMA (2004)

nancy and during each trimester of pregnancy, clarifying the time of initiation and duration of smoking and providing data on women who quit smoking early in pregnancy.Vermont implemented a revised smoking question on its birth certificate in 2000, and data for 2001-2002 indicated higher percentages because of more complete identification of smoking during pregnancy. 10 The impact from this change on national data was negligible because Vermont accounts for less than 0.2% of all U.S. births.All states are expected to revise their smoking questions, resulting in discontinuity of data such as those in this report, but improving accuracy of reporting.Women who quit smoking before or during pregnancy can substantially reduce or eliminate risks to themselves and their infants. 1 The National Partnership to Help Pregnant Smokers Quit includes CDC and approximately 60 other organizations, working to ensure that health-care providers assess smoking status before, during, and after pregnancy and provide best-practice counseling on smoking cessation.Evidence suggests that specific cessation programs have been at least partly successful. 6However, not all women have responded to this public health message 1 ; further efforts are needed to persuade these women of the health risks posed to their infants and themselves from smoking during pregnancy.
Persecuted Scientists
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Air bags may damage hearing
Journal: BMJ (1999)

Exercise is the answer for stress incontinence Urinary incontinence is a common condition in women, causing withdrawal from physical activities and reduction in quality of life.The most common type of urinary incontinence in women is genuine stress incontinence, with pregnancy and childbirth being the main cause.On p 487 Bø et al report the results of a 6 month comparison of the three most commonly recommended conservative treatments-pelvic floor exercises, electrical stimulation, and vaginal cones-in over 100 women with stress incontinence.Pelvic floor exercises were superior to the other methods in increasing strength of the pelvic floor muscles and reducing leakage; they were also well tolerated and had no side effects.
Is Skeletal Myoblast Transplantation Clinically Relevant in the Era of Angiotensin-Converting Enzyme Inhibitors?
Authors: Bruno Pouzet, Saïd Ghostine, Jean-Thomas Vilquin, Isabelle Garcin, Marcio Scorsin, Albert A. Hagège, Denis Duboc, Ketty Schwartz, Philippe Menasché
Journal: Circulation (2001)

Background There is compelling experimental evidence that autologous skeletal muscle (SM) cell transplantation improves postinfarction cardiac function. This study assessed whether this benefit is still manifested in the clinically relevant setting of a treatment by ACE inhibitors. Methods and Results A myocardial infarction was created in 99 rats by coronary artery ligation. They were divided into 4 groups. Two groups did not receive any drug and were intramyocardially injected 7 days after the infarct with either culture medium alone (control rats, n=16) or autologous SM cells (2.3×10 6 myoblasts) previously expanded ex vivo for 7 days (myoblasts, n=24). Two other groups received the ACE inhibitor perindoprilat (1 mg · kg −1 · d −1 ), started the day of the infarct and continued uninterruptedly thereafter, and underwent time-matched procedures, that is, they were intramyocardially injected at 7 days after infarction with either culture medium alone (ACE inhibitors, n=22) or autologous SM cells (2.5×10 6 myoblasts) previously expanded ex vivo for 7 days (ACE inhibitors+myoblasts, n=37). Left ventricular function was assessed by 2D echocardiography. At the end of the 2-month study, left ventricular ejection fraction (%, mean±SEM) was increased in all groups (myoblasts, 37.4±1.2; ACE inhibitors, 31.6±1.7; ACE inhibitors+myoblasts, 43.9±1.4) compared with that in control rats (19.8±0.7) ( P &lt;0.0001). The improvement in ejection fraction was similar in the ACE inhibitor and the myoblast groups (31.6±1.7 versus 37.4±1.2, P =0.0636). However, in the ACE inhibitor+myoblast group, this improvement was greater than that seen in hearts receiving either treatment alone (43.9±1.4 versus 31.6±1.7 in the ACE inhibitor group and 43.9±1.4. versus 37.4±1.2 in the myoblast group, P &lt;0.0001 and P =0.0084, respectively). Conclusions These data provide further support for the clinical relevance of autologous SM cell transplantation in that its cardioprotective effects are additive to those observed with ACE inhibitors.
Evaluation of infertility
Authors: L. Schwarzstein
Journal: JAMA (1983)

<h3>In Reply.—</h3> Dr Schwarzstein has raised a number of interesting points in his letter in response to our article, "Evaluation of the Male Partner of an Infertile Couple: An Algorithmic Approach." We are of common mind regarding the importance of a careful history and physical examination. The article focused on laboratory testing, since it was published as part of a series inThe Journalentitled TOWARD OPTIMAL LABORATORY USE. The history should, of course, include questions regarding cryptorchidism and genital infections. Physical examination includes careful palpation of the epididymis, vas deferens, and spermatic veins with the Valsalva maneuver, as indicated in several places in the article. We have used the Doppler stethoscope in an attempt to detect subclinical varicoceles with mixed success. Spermatic venography carries considerable expense to the patient and probably should be reserved for those with a high degree of suggestion of nonpalpable varicoceles, ie, increased number of