tbuckley/cabot-search huggingface dataset:
Teaching rheumatology in primary care
Authors: A S M JAWAD
Journal: Annals of the Rheumatic Diseases (2000)

CoVee consumption, RF, and the risk of RAStress is one of the factors that can trigger the onset of rheumatoid arthritis (RA).People working under deadline pressure, and people characterised as hard driving, "type A" personalities may be most likely to experience stress.These are the same people who may consume large quantities of coVee in order to stay at peak performance for longer periods of time.Possibly, therefore, the correlation reported by Heliövaara et al 1 between coVee consumption and RA may, in part, be due to the association between stress and RA.
Glucose-6-phosphate dehydrogenase deficiency in military recruits
Authors: D. E. Uddin
Journal: JAMA (1974)

A survey was conducted to determine the incidence of erythrocyte glucose6-phosphate dehydrogenase (G6PD) deficiency in Navy and Marine Corps black, male recruits. The incidence of G6PD deficiency in 20,810 recruits was 12.6%. The incidence of G6PD deficiency in individuals with hemoglobin AS trait or hemoglobin AC trait was the same as the incidence in persons with hemoglobin A. Automated testing of large numbers of persons for G6PD deficiency is technically feasible.
Intracranial surgery for cerebral artery aneurysms. Five years' experience
Authors: D. M. Kaufman
Journal: JAMA (1976)

During the previous five years, there were 133 cases of intracranial surgery for cerebral artery aneurysms. For patients with aneurysms in the anterior circulation and in good preoperative condition, the surgical morbidity was 28% and the mortality was 19%. A depressed sensorium preoperatively, an age of 50 years or above, and an interval of less than 15 days from rupture to surgery were associated with markedly increased mortality. The results of this series, which do not compare favorably with those from foreign referral centers, are partially the result of disproportionate numbers of patients in those poor-risk groups. The possible advantages of regionalization are, nevertheless, apparent. Further comparative studies should be conducted on an interinstitutional basis. (<i>JAMA</i>236:1707-1710, 1976)
PROFESSIONAL JEALOUSY
Authors: Herbert J. Levine
Journal: JAMA (1952)

<h3>To the Editor:—</h3> The American Medical Association has just completed two years of a strenuous campaign to foster and to promote better public relations with John Q. Public via the press and radio. It has made a gallant attempt to reawaken physicians so that American medicine can survive as a free and independent profession. It has attempted to remove a mysterious wall that sometimes has existed between physicians and the people in their community. It has tried to encourage physicians to participate more frequently in civic affairs and has so successfully stimulated such activities in many quarters that the communities now recognize physicians as human beings instead of as diagnostic machines. However, these energies expended by the American Medical Association to stimulate physicians to participate in community affairs may be doomed to at least partial failure unless the profession removes a problem from within its midst. This problem can be
Ankle sprain surgery a winner for athletes
Authors: C. Macek
Journal: JAMA (1982)

The escalating popularity of jogging and other running sports has resulted in an increased incidence of the most common athletic injury—the sprained ankle. But for those suffering from recurrent ankle sprains, surgical treatment is highly successful in returning the athlete to the gridiron or jogging trail, according to a study by orthopedic surgeons in Atlanta and Durham, NC. At the recent American Orthopaedic Foot Society meeting in New Orleans, Rick K. St Pierre, MD, an orthopedic resident at Emory University School of Medicine in Atlanta, reviewed 53 ankle ligamentous reconstructions carried out over a 21-year period by 16 surgeons. The patient population included 35 men and 15 women ranging in age from 14 to 40 years, with a mean age of 22 years. Many were college students who did not respond to conservative treatment, such as strapping or plaster casting. Three patients required bilateral surgery. The surgeons employed one of
Nicorette Gum Approved for Over-the-counter Marketing
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bruns' Beiträge Klin Chirurgie, Berlin
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Repression of hepatic δ-aminolevulinate synthase by heme and metalloporphyrins: Relationship to inhibition of heme oxygenase
Authors: E Cable
Journal: Hepatology (1993)

Heme- and tin-chelated metalloporphyrins are known to decrease the activity of hepatic δ-aminolevulinate synthase, the rate-controlling enzyme of heme synthesis. We performed experiments in primary chick embryo liver cells with tin-, zinc- and copperchelated porphyrins to assess their effects on activities of δ-aminolevulinate synthase induced by prior treatment of cells with glutethimide and ferric nitrilotriacetate. These different metalloporphyrins were tested to form the experimental foundation for eventual studies in patients with acute porphyrias, in which uncontrolled induction of hepatic δ-aminolevulinate synthase, which plays a key role in pathogenesis of disease. Zinc and tin porphyrins reduced δ-aminolevulinate synthase activities, whereas copperchelated porphyrins did not. When heme (iron protoporphyrin) was added with zinc or tin porphyrins, δ-aminolevulinate synthase activity was further reduced. Effects of the nonheme metalloporphyrins on δ-aminolevulinate synthase were closely correlated with their abilities to inhibit heme oxygenase (r = 0.78). The largest decrease of δ-aminolevulinate synthase (67%) was obtained with zinc mesoporphyrin and heme. Dose-response data indicated that only nanomolar concentrations of zinc mesoporphyrin and heme are required to obtain this effect. We found no effect of exposure to heme (10 μmol/L) or heme (200 nmol/L) plus zinc mesoporphyrin (50 nmol/L) on the half-life of activity of δ-aminolevulinate synthase (1.9 to 2.1 hr, regardless of treatment). This result suggests that the repressive effect of heme is directed toward decreasing synthesis, increasing breakdown or decreasing the translation of the messenger RNA of δ-aminolevulinate synthase. Reduction of δ-aminolevulinate synthase by zinc mesoporphyrin and heme occurred after induction of δ-aminolevulinate synthase by exposure of gliver cells to several chemicals. These results suggest that low doses of zinc mesoporphyrin and heme, in combination, may be a useful treatment for patients with acute porphyria. (HEPATOLOGY 1993;18:119–127).
The gift of laughter
Authors: R. D. Liechty
Journal: JAMA (1979)

Hence loathéd Melancholy... Haste thee nymph, and bring with thee Jest and youthful Jollity, Quips and Cranks, and wanton Wiles... Sport that wrinkled Care derides, And Laughter, holding both his sides. THREE centuries ago, John Milton thus invoked the laughing good times in<i>L'Allegro</i>. Today, in much the same spirit, albeit in less majestic words, we hear the familiar "Thank God it's Friday." Regardless of the words or the era that spoke them, people have always needed laughter. Distinguishing man from all the other animals, the belly laugh is innately human. In his introduction to Loren Eiseley's<i>The Star Thrower</i>, W. H. Auden puts laughter—the spirit of carnival—into perspective. According to Auden, successful lives must pay respect to three worlds: Work, Worship, and Carnival. Most important, the three must balance. Without Worship and Work, Laughter turns ugly and humor grubby and pornographic, the ultimate downfall of many comics. Without Laughter
SANITARY CONDITIONS IN THE BAHAMAS.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Commentary
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Assessment of Maternal Toxicity, Embryotoxicity and Teratogenic Potential of Sodium Chlorite in Sprague-Dawley Rats
Authors: Daniel Couri, Carl H. Miller, Richard J. Bull, John M. Delphia, Elsayed M. Ammar
Journal: Environmental Health Perspectives (1982)

Groups of up to 13 pregnant rats were individually caged. Body weight, food and water consumption were recorded at days 1, 8, 15 and 22 of gestation and the dams were treated on days 8-15 with sodium chlorite, 0.1%, 0.5% or 2% in drinking water or by injection of 10, 20, or 50 mg/kg IP or by gavaging with 200 mg/kg. To prevent ingestion of stillborn pups some dams were sacrificed at day 22. Other dams were allowed to deliver at term. Fetuses were weighed, measured and examined for soft tissue and skeletal malformations. Sodium chlorite, 20 or 50 mg/kg daily IP or gavaging with 200 mg/kg, caused vaginal and urethral bleeding. Doses of 10, 20 or 50 mg/kg daily IP caused 0, 50 and 100% mortality of dams, respectively. No deaths were caused by sodium chlorite in the drinking water, but the dams' body weight, water and food consumption decreased during all treatments except 0.1% in the drinking water. Blood smears from the dams injected IP or drinking 2% sodium chlorite showed irregular, bizarre and ruptured erythrocytes. Injection of 10 or 20 mg/kg or drinking 2% resulted in decreased litter size and increased stillbirths and resorption sites. Drinking 0.1% or 0.5% sodium chlorite did not produce any significant embryotoxicity. With all treatments, no significant gross soft tissue or skeletal malformations were observed. Postnatal growth of the pups was not affected by any treatment of the dams during the gestation period.
The prevalence and pattern of chemotherapy induced peripheral neuropathy (CIPN) among women with breast cancer receiving care in a large community oncology practice.
Authors: Natalie Brooke Simon, Michael A. Danso, Thomas Alberico, Ethan M. Basch, Antonia Vickery Bennett
Journal: Journal of Clinical Oncology (2015)

e17729 Background: CIPN is a common side effect of taxane-based chemotherapy agents. This study examined the prevalence, severity, and risk factors of CIPN and its impact on quality of life (QOL) among women treated for breast cancer in a large U.S. community oncology practice. Methods: A cross-sectional survey study was conducted in August 2014. Women previously treated with taxane-based chemotherapy for early stage breast cancer completed a set of European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaires (QLQ), including the QLQ-C30 for health-related QOL, the QLQ-BR23 for breast cancer-related QOL, and the QLQ-CIPN20 for CIPN. Each subscale is scored 0-100 where higher scores indicate better function. Clinical data were abstracted from the medical record. Bivariate analyses were conducted to test pre-specified hypotheses. Results: 126 women with mean age 56.7 years (SD = 11.8) were stage I-II (79.4%) or stage III (20.6%) at the time of the survey; 65.1% were White and 27.8% were Black or African American. 73.0% of women reported they had CIPN. The mean time since last taxane chemotherapy cycle was 144.9 weeks (SD = 112.9). The mean (SD) score of QLQ-C30 global health status/QOL was 77.0 (20.3) and physical function was 85.7 (17.1). QLQ-CIPN20 mean scores for the sensory, motor, and autonomic subscales were 18.9 (23.1), 18.6 (18.7), and 17.1 (21.8), respectively. Presence of CIPN was associated with patient referral and visitation to a neurologist or pain specialist (p < 0.05). CIPN symptom severity was negatively correlated with global health status/QOL and physical and role functioning (range of r= -0.46 to -0.72). Severity of CIPN was not associated with age, body mass index, diabetes, or cumulative taxane dosage, but CIPN sensory impairment was marginally greater for patients treated with paclitaxel compared to docetaxel (23.3 vs 15.6, p = 0.06). Conclusions: CIPN was prevalent in this community oncology practice and significantly impacts function and QOL. These data highlight the importance of developing therapies for the mitigation of CIPN to enhance the long-term function and QOL of women with breast cancer.
Erratum
Journal: BMJ (1895)

tion had improved, and she appeared to be going on quite well.Two or three days later she passed blood in her urine and became restless.She could not tolerate the catheter, and her symptoms became so grave that a further operation was out of the question.On post-mortem examination, twenty-four hours after death, there was complete closure of the aperture at the site of operation and no signs of peritonitis.The bladder was thickened and contained two phos- phatic concretions; there were two cavities in the right kidney containing pus, and a small ovarian cyst on the left side.Mr. Stretton also reported a successful case of opera- tion for Sarcoma (round-celled) of the Front of the Chest in a man aged 22.There were two tumours.Both were removed by one incision, leaving a large surface, which could not be covered by skin.Skin grafts were planted from time to time, and the whole had healed in three months.Recovery was uninterrupted.-Dr.EVANs showed a case of Extreme En- largement of the Thigh Bone following Fracture.-Mr.P. E. DAVIES showed a female child, aged 11 years, suffering from Congenital Syphilis with well-marked Ulceration of the Soft Palate, which he considered a rare condition.-ThePBEsI-DENT read a paper on Scarlet Fever.
Guide for Collaboration of Physician, Social Worker, and Lawyer in Helping the Unmarried Mother and Her Child
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
DR. PETER M. MURRAY, FIRST NEGRO MEMBER IN THE HOUSE OF DELEGATES
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PROFIT IN NEW YORK'S GARBAGE.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Therapeutics.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal