tbuckley/cabot-search huggingface dataset:
Comprehensive allelotype study of hepatocellular carcinoma
Authors: Massimo RONCALLI, MAURO BORZIO, PAOLO BIANCHI, LUIGI LAGHI
Journal: Hepatology (2000)

To the Editor: I read with great interest and more than a little dismay the article by Myers, Gregor, and Marotta 1 on the cost-effectiveness of hepatitis A vaccination in patients with chronic hepatitis C. While I found the article to be very well written and thorough, I find the premise for the article to be totally unacceptable.Are we to withhold a simple vaccination from our patients, knowing that they run the risk of severe morbidity or death simply because it may not be "cost effective" in a population study?This article calls to mind a story that was recently played out in the courts in the United States.There was once a large automobile manufacturer that produced a vehicle it knew was unsafe.Not only did they know that it was unsafe, they also knew how to fix the problem to render the vehicle safe.However, rather than do the right thing and fix the vehicle (at a cost of $11 per vehicle), they embarked on a course similar to Myers et al.They first calculated the cost of correcting the defect and then compared it with the cost they may incur if the defect was not corrected.They used data from the federal government and that the National Highway Traffic Safety Administration made available to them.They calculated the average damage per person killed by their vehicle.They added medical costs, property damage, insurance administration, legal and court costs, employer losses, victim pain and suffering, and funeral bills as well as "other costs."When they found that this cost would be less than the cost of correcting the defect on the vehicle, they elected to take their chances in court.Their strategy ultimately landed them in court and resulted in one of the largest settlements in the American legal system.The ethics involved in their decision-making process was headline news throughout the nation.The parallels between this story and the conclusions drawn from this article I find to be quite remarkable.I can see myself in the future consoling Mrs. X upon the death of her husband from hepatitis A superimposed on hepatitis C, a disease that could have been prevented by a simple vaccination, by handing her the article and saying, "but as you can see here, clearly it would not have been cost effective for me to have given your husband a simple vaccine."I was surprised that this article did not provoke more editorial comments from the editors of HEPATOLOGY and I certainly hope that the ACIP does not reconsider its stance on vaccinating all patients with hepatitis C with the hepatitis A vaccine.
Infectious Disease
Authors: Daniel L. Weiss
Journal: JAMA (1974)

A symposium on infectious diseases in honor of Dr. Wesley W. Spink, which originally appeared in<i>Medicine</i>, is now available in this fascinating small volume. The articles cover a wide variety of subjects in succinct and informative style. The 19 reports discuss such subjects as current concepts of pyelonephritis, clinical approach to infectious diarrhea, sources of hospital infection, pharmacological studies of the therapy of shock, studies on Gram-negative bacteremic shock, a wide variety of infectious disease management and therapy problems, immune mechanisms, viral disease, and fungal infection, and the volume closes with three articles on mechanisms of immunity and failure of immune and phagocytic mechanisms. Each of the presentations is authoritative and thoughtful, and displays concern for the practical application of recent advances in knowledge of infection and resistance. This grouping of articles makes available to anyone dealing with infectious problems a wealth of carefully considered material that would be
FACTS AND OPINIONS RELATING TO TUBERCULOSIS, WITH COMMENTARIES
Authors: H. Ancell
Journal: BMJ (1854)

hiq hat paper,!Ixpained the sense in which the term "'tubiln i s app[ia d to a diseasd condition of the ;sM leWm y the oigin alike of consumption and of cro- fula.This disease, in theview of some pathologists, is a -morbid " action", as indicated by the radical meaning of the suffix "ouis"; and tubercle is the special anatomico- thologicl element of the morbid condition or morbid acton.The paper embraced facts relating to the frequency .oftubercle in 2,161 autopsies, made at St. George's Hospi- t.l, during a period of ten years, the relative number of males and females affected in this number of cases, and other interesting particulars, drawn from the Decennium Pathogi-m of Dr. Chambers.The present paper will give some account of the pathological appearances in con- non with tubercular deposits in the lungs, observed in the same series of cases.Of all the morbid appearances accompanying tubercle in the lungs, the results of inflammatory action are undoubt- edly the most frequent and the most important.Various * opinions were held at one time as to the relation that sub- sists between the speeial morbid deposit and these appear- * From Medical Times and
Chemical Carcinogenesis
Authors: Emmanuel Farber
Journal: New England Journal of Medicine (1981)

THE perception of cancer as a disease primarily related to the environment has been progressively strengthened since the publication of a Medical Progress article on chemical carcinogenesis in 1971.1 By the mid-1960s, the view of the cause and pathogenesis of cancer had already begun to change radically from that of previous decades, during which no clear perception of the possible role of the environment in the genesis of most of the major forms of cancer was evident. Although the relation of cancer to environmental hazards in the work place and to a few unusual cultural patterns around the world was . . .
Drugs
Authors: Harold P. Lehmann
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Corrigenda
Journal: BMJ (1934)

THE BtITISR r~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ã nd less the aggregate depreciation allowances, but exclud- ing the non-effective allowance for 1935-6.He will then have received the full amount due in law and in equity.Private Motoring Expenses J. F. M." has in the past been allowed running expenses and wear and tear in respect of his car ; the inspector of taxes suggests that one-tenth of each kind of deduction should be treated as applicable to private use.Should the wear and tear allowance be added to the expenses claimed, which cover the whole cost of running, etc.? * Whether one-tenth is reasonable or excessive depends on the extent of private use of the car, and varies so much that no rule of thumb is of much use as a guide.If that is a fair ratio it does apply to the wear and tear allowance as well as to the out-of-pocket expenses.That allowance is correctly treated as an addition because it is in anticipation
Leads from the MMWR. Leading work-related diseases and injuries--United States
Journal: JAMA (1984)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Caring for the uninsured and underinsured
Authors: Gerald H. Holman
Journal: JAMA (1991)

<h3>To the Editor.—</h3> The availability and affordability of health care is no longer only a medical concern. Our great state of Texas has one of the highest percentages of uninsured and underinsured citizens in the United States. Recognizing this problem as it applies to the State of Texas, the Texas Medical Association (TMA), in response to its House of Delegates, in 1990 began a study bringing together a statewide coalition with representation from businesses, consumers, hospital administrators, insurers, legislators, physicians, and trial lawyers. We successfully developed a consensus for a plan that will begin to address the spiraling premium costs, decreased availability of health insurance, and lack of access to health care for more than 2.3 million uninsured Texans whose incomes are less than 200% of the poverty level. This plan will also address some of the issues experienced by the underinsured. The consensus document, "Insuring the Uninsured: A Plan
Role of computed tomography in assessing "operability" of bronchial carcinoma
Authors: J Weir, E. M Robertson, A V Foote, J S Cockburn
Journal: BMJ (1986)

To try to assess the accuracy of predicting "operability" (as defined by local policy) of bronchial carcinoma 300 patients underwent computed tomography of the thorax in a prospective study.The results of 141 patients showed an agreement between computed tomographic and surgical (including pathological) findings in those patients who had received operations.Most of the other patients had more advanced disease than suggested by the findings of computed tomography.A total of 118 patients did not receive operations: in 47 their disease was considered to be inoperable on the basis of computed tomographic findings alone, and this was accepted by the cardiothoracic surgeons after consultation.Thirty two other patients had further evidence of metastatic disease on other investigations.Computed tomography of the thorax should be performed early in the assessment of operability of patients with bronchial carcinoma and before the start of an extensive search for metastatic disease.
Incorrect Axis Scale in Figure
Authors: Stephen Devries, Walter Willett, Robert Bonow
Journal: JAMA (2019)

Adriana Bastidas, MD; Javier de la Serna, MD; Mohamed El Idrissi, MSc; Lidia Oostvogels, MD; Philippe Quittet, MD; Javier López-Jiménez, MD, PhD; Filiz Vural, MD; David Pohlreich, MD; Tsila Zuckerman, MD; Nicolas C. Issa, MD; Gianluca Gaidano, MD, PhD; Je-Jung Lee, MD; Sunil Abhyankar, MD; Carlos Solano, MD, PhD; Jaime Perez de Oteyza, MD, PhD; Michael J. Satlin, MD; Stefan Schwartz, MD; Magda Campins, MD, PhD; Alberto Rocci, MD, PhD; Carlos Vallejo Llamas, MD, PhD; Dong-Gun Lee, MD, PhD; Sen Mui Tan, MD; Anna M. Johnston, MBBS; Andrew Grigg, MBBS, FRACP, MD; Michael J. Boeckh, MD, PhD; Laura Campora, MD; Marta Lopez-Fauqued, PhD; Thomas C. Heineman, MD, PhD; Edward A. Stadtmauer, MD; Keith M. Sullivan, MD; for the ZOE-HSCT Study Group Collaborators
Medical News
Journal: JAMA (1981)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Extent and prevalence of illicit drug use as reported by 56,745 students
Authors: J. T. Gossett
Journal: JAMA (1971)

A survey of all junior and senior high students in the nation's tenth largest public school system revealed that 28% reported experimentation with an illicit drug, 8% reported use more than ten times, and 4% reported frequent current use. Of 61 drugs, alcohol, tobacco, glue, marihuana, solvent inhalants, and nonprescription stimulants were most commonly reported. Boys reported more use than girls, upper class students more than lower. Peers were most often the source. The survey appears to reflect high levels of reliability and validity for an approach of this kind. Two repetitions of the survey are planned in the 1970 to 1971 school year.
Previous Medication Hampers Pheochromocytoma Diagnosis
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reply
Authors: C. T. Jansen, P. Morse
Journal: British Journal of Dermatology (1988)

Journal Article Reply Get access C. T. Jansen, C. T. Jansen Department of Dermatology, University of Turku, SF‐20520 Turku 52, Finland Search for other works by this author on: Oxford Academic Google Scholar P. Morse P. Morse Efamol Ltd, Woodbridge Meadows, Guildford, Surrey GU1 1BA, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 118, Issue 3, 1 March 1988, Pages 450–451, https://doi.org/10.1111/j.1365-2133.1988.tb02446.x Published: 01 March 1988
BIRTH INSURANCE.
Journal: JAMA (1905)

In a number of European countries maternity insurance is a long-established fact. Italy has recently provided for government birth insurance. The recent unfavorable opinion of the Minnesota insurance commissioner is therefore of present interest. He ruled that "maternity does not present the characteristics of a thing which may properly be insured against," and refused the American Mothers' Birth Insurance Association permission to do business in the state. The<i>Chronicle</i>(insurance paper) thinks that this decision is not well founded in reason. Of course, there is no financial loss in maternity, but there is necessary and immediate expense to be met, and this is a proper subject for insurance. Maternity in a sense is voluntary, but only in part, and so, to at least an equal degree, are death, sickness, casualty and fire, all of which are recognized as insurable events.
Hemodynamics after orthotopic liver transplantation: study of associated factors and long-term effects
Authors: A GADANO
Journal: Hepatology (1995)

Among 68 liver transplant recipients, 190 hemodynamic studies were performed to evaluate the role of sepsis, anemia, acute graft rejection, and persistent portosystemic shunts. The hemodynamic outcome after orthotopic liver transplantation (OLT) in stable patients was also determined. Patients with sepsis showed a significant increase in cardiac index (5.1 ± 0.9 vs. 3.4 ± 0.7 L/min m2) and hepatic venous pressure gradient (6.3 ± 2.9 vs. 3.3 ± 2.1 mm Hg), compared with patients without sepsis. Cardiac index was higher in patients with, than in patients without, anemia (4.1 ± 0.6 vs. 3.0 ± 0.6 L/min m2). The hepatic venous pressure gradient was higher in patients with than in patients without acute graft rejection (5.1 ± 2.9 vs. 2.6 ± 1.2 mm Hg). Among patients with acute rejection, the hepatic venous pressure gradient was higher in patients with severe rejection than in those with moderate or mild rejection (7.2 ± 3.3 vs. 4.6 ± 2.4 and 2.8 ± 0.9 mm Hg). In the postoperative period, in patients undergoing transplantation for acute liver failure, the hepatic blood flow was normal and significantly lower than in patients receiving transplant for cirrhosis (1.15 ± 0.37 vs. 1.96 ± 0.71 L/min). In patients undergoing transplantation for cirrhosis, cardiac index, azygos, and hepatic blood flows significantly decreased after 1 year compared with the first 6 postoperative months. Multivariate analysis showed that sepsis, anemia, and time after OLT were independent variables influencing cardiac index. Sepsis, time after OLT, and the existence of portosystemic shunts were independent variables influencing hepatic blood flow. These results show that sepsis, anemia, acute graft rejection, and persistent portosystemic shunts induce modifications in hemodynamics in liver transplant recipients. Furthermore, in patients who undergo OLT for cirrhosis, the posttransplantation hyperdynamic syndrome tends to normalize with time. (Hepatology 1995; 22:458–465.)
INDWELLING DOUBLE-PIGTAIL PLASTIC STENTS FOR THE TREATMENT OF DISCONNECTED PANCREATIC DUCT SYNDROME-ASSOCIATED PERIPANCREATIC FLUID COLLECTIONS: LONG-TERM SAFETY AND EFFICACY
Authors: P Gkolfakis, A Bourguignon, M Arvanitakis, A Baudewyns, P Eisendrath, D Blero, A Lemmers, M Dellhaye, J Devière
Journal: Endoscopy (2020)

Aims Transmural indwelling double-pigtail stents (DPS) are recommended for patients with disconnected pancreatic duct syndrome (DPDS) and peripancreatic fluid collections (PFC). Long-term safety and efficacy of indwelling DPS placement were evaluated.
TOTAL ABSTAINERS AND LIFE INSURANCE.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Klinische Epikrisen zugleich Beiträge zur Differentialdiagnose.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hepatic microsomal UDP-glucuronosyltransferase does not function as a UDP-glucuronic acid transporter . Brigham and Women's Hospital, Harvard Medical School, Boston, MA and *Academic Medical Center, Amsterdam, The Netherlands
Journal: Hepatology (1995)

Higenamine (HG), an active ingredient of Aconite root in Chinese herbal medicine, is mainly metabolized by UDP-glucuronosyltransferases (UGT). However, the systematic glucuronidation of HG in humans remains unclear. The purpose of this study was to investigate the glucuronidation of HG.12 recombinant human UGT (rUGT) isozymes were used to characterize the HG glucuronidation. Liver microsomes from male and female mice, rats, guinea pigs, dogs, and humans were used to determine the species and gender differences using liquid chromatography-mass spectrometry.One monoglucuronide was detected in reactions catalyzed by rUGT1A6, rUGT1A8, rUGT1A9, also human and dog liver microsomes. UGT1A9 is the most important glucuronosyltransferase that metabolizes HG. Because carvacrol, a specific inhibitor of UGT1A9, can significantly decrease the glucuronidation of HG in Human liver microsomes and UGT1A9. HG metabolism by UGT1A9 described in Michaelis-Menten kinetics (Km = 15.4 mM, Vmax = 2.2 nmol/mg/min) and glucuronidation in liver microsomes were species dependent. Gender did not affect the kinetic parameters among species except in rats.UGT1A9 is a major isoenzyme responsible for the glucuronidation of HG in Human liver microsomes (HLMs). Dog may be an appropriate animal model to evaluate HG metabolism.