tbuckley/cabot-search huggingface dataset:
ACTR-47. PATIENTS WITH EGFR AMPLIFICATION BUT WITHOUT EGFRvIII EXPRESSION HAVE IMPROVED BENEFIT COMPARED TO THOSE WITH EGFRvIII EXPRESSION IN SAMPLES OF THE INTELLANCE 2/EORTC 1410 RANDOMIZED PHASE II TRIAL
Authors: Pim French, Johan Kros, Iris de Heer, Marica Eoli, Juan Sepulveda, Annemiek Walenkamp, Jean-Sebastien Frenel, Enrico Franceschi, Paul Clement, Michael Weller, Peter Ansell, Jim Looman, Earle Bain, Marie Morfouace, Thierry Gorlia, Vassilis Golfinopoulos, Martin van den Bent
Journal: Neuro-Oncology (2018)

A randomized phaseII trial on EGFR-amplified recurrent glioblastomas showed that Depatux-M+TMZ improves overall survival compared to the single agent control arms. We performed targeted next-generation-sequencing to identify patients that benefit from the combination. DNA and RNA was isolated from samples, collected at initial diagnosis, and selected for regions with highest tumor content. Target selection was done using the Trusight170 panel (Illumina). Patients were eligible with centrally confirmed EGFR amplification, defined as EGFR/CEP 7 (centromere) ratio 2 in 15% of cells (FISH). DNA and RNA data were generated from 233 and 234 samples respectively (of the 260 study patients). High-copy gene amplification was detected in EGFR (n=202), MDM2 (n=20), MDM4 (n=22), CDK4 (n=24) and CDK6 (n=5) which correlated with high expression levels. With this assay, 17 tumors did not show EGFR copy number (cn) aberrations (cn < 2.8), a further 14 showed copy number changes consistent with trisomy (2.8< cn < 4). Most EGFR amplified tumors also had additional genetic changes in the EGFR locus including point mutations (111/202), splice variants (132/202, the most common being EGFRvIII (n=96) or fusion genes (13/202). Response to treatment was not correlated to EGFR gene expression or amplification levels though, since EGFR amplification was a pre-requisite for inclusion, the majority of cases expressed high levels of EGFR. Preliminary analysis suggests that subjects with EGFR amplification but without EGFRvIII expression benefitted more than those with EGFRvIII expression (median survival 14.6 v 9.2 months, HR 0.57, P=0.04). No such association was identified in the control arms; median survival of EGFRvIII-negative v positive was 7.7 v 8.3 (Depatux-M) and 8.8 v 7.5 (TMZ/CCNU) months. CONCLUSION: Depatux-M in combination with TMZ confirmed the OS improved outcome in EGFR amplified recurrent glioblastoma. The improved outcome may be related to an absence of EGFRvIII expression.
Menstrual Extraction
Authors: Geoffrey Davis
Journal: JAMA (1974)

<h3>To the Editor.—</h3> The COMMENTARY on menstrual extraction (228:849, 1974) is gravely in error in fact, opinion, and judgment on virtually every count. The authors appear to speak for what now could be termed "institutionalized abortion" and appear to feel threatened. It is a travesty of current medical philosophy that anyone<i>could</i>attempt to argue positive virtues for abortion in face of innovative, simpler means to rational fertility control. The new terms appeared in response to the clear need for nomenclature to distinguish the idea "menses induction as early as possible as fertility control" from both abortion and contraception. Some terminological confusion appeared from press accounts in mid 1972. It is intriguing to see the confusion perpetuated in mainstream medicine two years later. Menstrual<i>extraction</i>is vacuum curettage, usually self-employed, at or about due date of onset to avert<i>menstruation;</i>in this use fertility control is a spin-off benefit. The term
Prescriptions
Authors: M. Therese Southgate
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Value of Dundee coronary risk-disk.
Authors: T. Randall, J. Muir, D. Mant
Journal: BMJ (1992)

pathology present in impaired glucose tolerance is complex.We approached the problem of determining whether Lp(a) is a possible factor in why such subjects develop coronary artery disease by examining them before clinical coronary artery disease was established.Rather than suggesting that the pathological process-for example, impaired glucose tolerance -accounts for differences in Lp(a) concentration, we suggest that differences in either Lp(a) concentration or the size of the apoprotein(a) isoform in such subjects could account for their subsequent development of coronary artery disease.To this end a larger long term prospective study is re- quired, not so much to avoid the bias from the effect of inheritance of the apoprotein(a) isoform, but to examine the effect ofthe potential differences in this on the development of coronary artery disease in what is a common condition.
Methods for Evaluating the Effects of Environmental Chemicals on Human Sperm Production
Authors: Andrew J. Wyrobek
Journal: Environmental Health Perspectives (1983)

Sperm tests provide a direct and effective way of identifying chemical agents that induce spermatogenic damage in man. Four human sperm tests are available: sperm count, motility, morphology (seminal cytology) and the Y-body test. These sperm tests have numerous advantages over other approaches for assessing spermatogenic damage, and they have already been used to assess the effects of at least 85 different occupational, environmental, and drug-related chemical exposures. When carefully controlled, seminal cytology appears to be statistically more sensitive than the other human sperm tests and should be considered an integral part of semen analysis when assessing induced spermatogenic damage. Human sperm studies have complex requirements and, before sampling, careful consideration should be given to exposure details, group size and makeup, as well as animal and human data that indicate spermatogenic effects. Several study designs are possible and should include questionnaires covering medical and reproductive histories as well as known confounding factors. Animal sperm tests, such as the mouse morphology test, may be used to identify the toxic components of a complex mixture. Animal tests may also help assess the chemical effects on fertility and reproductive outcome in cases when human data are incomplete. Further efforts are needed in these areas to develop improved human sperm tests sensitive to induced spermatogenic damage, to develop improved animal models of induced spermatogenic damage, to understand the relationships among sperm changes, fertility, and reproductive outcome, and to develop sperm tests with express mutational end points.
ABSTRACTS
Journal: Circulation (1952)

Because patients with congestive heart failure fail to eat adequately, and because liver function is im- paired in this disorder, depletion of the protein stores and nonovert vitamin deficiency states are not uncommon; the resulting hypoproteinemia will contribute to the formation of more edema and will lessen the responsiveness to mercurial diuretics.Re- fractoriness to mercurial diuretics, when due to this cause, can be overcome by the concurrent use of salt-free albumin intravenously.The supplemental parenteral administration of B-vitamin concentrates, when insufficient intake of thiamine is suspected, may eliminate the manifestations of congestive fail- ure when other conventional therapeutic measures have not accomplished the desired result.It is to be anticipated that the development of atherosclerosis and particularly coronary atherosclerosis can be re- tarded by the ingestion of a diet low in animal and vegetable fats.This reduction in fat intake must be compensated for by the ingestion of a high proteinhigh carbohydrate diet, but the careful selection of foodstuffs in these categories is essential.Up to now, no other means of affecting the disturbed lipid me- tabolism of atherosclerotic patients has proved to be effective.W\ENDKOS
Corrigendum
Journal: Allergy (2007)

AllergyVolume 62, Issue 9 p. 1100-1100 Free Access Corrigendum This article corrects the following: Sublingual immunotherapy with a standardized cat dander extract: evaluation of efficacy in a double blind placebo controlled study E. Álvarez-Cuesta, P. Berges-Gimeno, E. G. Mancebo, E. Fernández-Caldas, J. Cuesta-Herranz, M. Casanovas, Volume 62Issue 7Allergy pages: 810-817 First Published online: June 15, 2007 First published: 04 August 2007 https://doi.org/10.1111/j.1398-9995.2007.01520.xAboutSectionsPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat In (1), the author listing was published as follows: E. Álvarez-Cuesta, P. Berges-Gimeno, E. G. Mancebo, E. Fernández-Caldas, J. Cuesta-Herranz, M. Casanovas This has now been requested to read: E. Álvarez-Cuesta, P. Berges-Gimeno, E. González-Mancebo, E. Fernández-Caldas, J. Cuesta-Herranz, M. Casanovas Reference 1 Álvarez-Cuesta E, Berges-Gimeno P, Mancebo EG, Fernández-Caldas E, Cuesta-Herranz J, Casanovas M. Sublingual immunotherapy with a standardized cat dander extract: evaluation of efficacy in a double blind placebo controlled study. Allergy 2007; 62: 810– 817. Wiley Online LibraryCASPubMedWeb of Science®Google Scholar Volume62, Issue9September 2007Pages 1100-1100 ReferencesRelatedInformation
Cardiac Glycosides
Authors: Dale G. Friend
Journal: New England Journal of Medicine (1962)

Absorption, Distribution and EliminationDigitoxin is entirely absorbed from the gastrointestinal tract, digoxin approximately 80 per cent, lanatoside C 10 per cent, and ouabain little if at all. After injection, approximately 60 per cent of digitoxin is bound to plasma protein, but only 50 per cent can be found in the blood after three minutes, and none at the end of three hours. When given orally, it cannot, even when given in large doses, be detected in the blood. Digoxin is not bound to protein to any extent and rapidly disappears from the blood stream after injection. None can be . . .
HLA-Cw6 and psoriasis
Authors: L. Chen, T.-F. Tsai
Journal: British Journal of Dermatology (2018)

Summary Psoriasis is a disease which causes, among other symptoms, red, scaly patches of skin. It is a complex disease because there are several different factors that work together to cause it, including those that are environmental and those that are genetic. Because of these variables, psoriasis can affect patients differently, with varying symptoms, areas of the body affected and how treatments work. Different versions of the same gene are called alleles, and some alleles make a person more prone to certain diseases or symptoms. Psoriasis susceptibility alleles have been thought to play an important role in the development of the disease, in particular one called HLA-Cw6 which has been linked to features such as early onset psoriasis and a certain type of skin patches (lesions) called guttate lesions. This article, from the National Taiwan University Hospital, is a review, summarizing the key findings from a range of studies into HLA-Cw6 and psoriasis. The worldwide frequency of HLA-Cw6 allele varies greatly, but is generally higher in Caucasians. The allele is associated with Type I early onset psoriasis. Stress, obesity, and an infection called streptococcal pharyngitis are commonly found in patients with HLA-Cw6 allele (HLA-Cw6 positive patients). HLA-Cw6 is found to be linked to a type of psoriasis called guttate psoriasis in some studies. In addition, patients carrying the allele are more likely to have lesions on their arms, legs and trunk. Studies also show that HLA-Cw6 positive patients have more success with certain treatments than people without the allele. All of these findings could eventually help predict and plan for how different patients’ psoriasis develops and is treated, although more research is needed first.
A Question of Ethics
Authors: Rand A. David
Journal: Annals of Internal Medicine (2000)

Letters7 November 2000A Question of EthicsRand A. David, MDRand A. David, MDMount Sinai School of Medicine (Elmhurst) Program; Elmhurst, NY 11373 (David)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-133-9-200011070-00032 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Certification by the American Board of Internal Medicine includes an evaluation of “moral and ethical behavior in the clinical setting” for the medical resident.Some residents commit to a subspecialty training program, then fail to follow through, leaving the program high and dry for a fellow. This occurs only too often when a resident is in an exchange visa program, which stipulates that after fellowship the physician must leave the United States for at least 2 years. However, if a graduate of a residency program practices in a medically underserved area in the United States after residency, ... Author, Article, and Disclosure InformationAffiliations: Mount Sinai School of Medicine (Elmhurst) Program; Elmhurst, NY 11373 (David) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 7 November 2000Volume 133, Issue 9Page: 750KeywordsBehaviorFellowshipsGraduate medical educationPatientsResidencySub-specialty care ePublished: 7 November 2000 Issue Published: 7 November 2000 CopyrightCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Extracts from Three Lectures on Tubercular Diseases of Bones and Joints
Authors: W. W. Cheyne
Journal: BMJ (1890)

LECTURE I.-(Continued)IN discussing the morbid anatomy of tubercular diseases of b3nes and joints we shall study, in the first instance, the changes which occur in the synovial membrane, and, in the secrnd place.those which occur in the bones.The di-ease may bcw primary or secondary in either of these tissues, and the character of tl e changes which take plecs varie3 accordingly.
Gene Expression Signatures That Delineate Biologic and Prognostic Subgroups in Peripheral T-Cell Lymphoma
Authors: Javeed Iqbal, George W. Wright, Andreas Rosenwald, Randy D. Gascoyne, Dennis D Weisenburger, Chao Wang, Timothy C. Greiner, Bin Tean Teh, Philippe Gaulard, Pier Paolo Piccaluga, Stefano A. Pileri, Lynette Smith, Lisa M. Rimsza, Elaine S. Jaffe, Elias Campo, Jan Delabie, Rita M. Braziel, James R. Cook, Raymond R. Tubbs, Wing Y Au, Shigeo Nakamura, Masao Seto, Francoise Berger, Laurence de Leval, James O. Armitage, Julie M Vose, Louis M. Staudt, Wing Chung Chan
Journal: Blood (2012)
Popular Lunacy.
Authors: L. Harrison Mettler
Journal: JAMA (1896)

Chicago, April 9, 1896. <h3>To the Editor:</h3> —In a recent editorial entitled "Popular Lunacy," you refer to the highly educated young woman of London who suddenly asserted her conviction that marriage was immoral and her intention to live in concubinage with a workingman. In the following paragraph you say, "whatever may have been the actual condition of the woman the moral of the decision (made by the Commissioners in Lunacy) is this: Insanity must be of a definite type, no new forms are to be discovered, our knowledge of it is exhaustive. This is an opinion, that, however satisfactory it may be to the legal mind, can have no medical standing whatever, its mere statement is a<i>reductio ad absurdum</i>in itself." Herein, it seems to me, you have touched the cause of much of the real trouble in regard to expert testimony in our courts, especially in cases of
Contact Lenses
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
One third of children in road traffic accidents develop post-traumatic stress disorder
Journal: BMJ (1998)

Antenatal screening for syphilis should not be abandoned Antenatal screening for syphilis in the United Kingdom is routine but lacks any formal or evidence based policy.On p 1617 Hurtig et al report on the first national surveys of syphilis in pregnancy and congenital syphilis.Over three years 121 of the 139 pregnant women treated for syphilis by genitourinary medicine specialists were detected through antenatal screening.Women from ethnic minority groups, who were born abroad, or who were living in London were overrepresented, but cases also occurred in white women born in the United Kingdom and living outside London.Seventeen children were found with presumptive or possible congenital syphilis; mothers not receiving antenatal care or late booking was a risk factor.The authors conclude that abandoning or targeting screening is inadvisable.
Long-term prospective study of development of hepatocellular carcinoma in compensated cirrhosis
Authors: Alessandra Pivetti, Paola Todesca, Federica Bertellini, Marcello Bianchini, Veronica Bernabucci, Barbara Lei, Mariagrazia Del Buono, Laura Turco, Filippo Schepis, Erica Villa
Journal: Journal of Hepatology (2020)
Human Transplantation
Authors: Bernard Fisher
Journal: JAMA (1968)

The editors, two eminent transplantation biologists, have compiled a volume which admirably accomplishes their objectives. They, and 55 other internationally known authorities, have, in 44 contributions, provided a clear "view of the present scope and possible future focus of human organ transplantation." From the introduction by Sir Peter Medawar to the final chapter concerned with experimental brain transplantation, the book is a scholarly summation of appropriate basic scientific knowledge and clinical accomplishments in a rapidly expanding and altering field. The first of four parts provides an introduction to human transplantation via historic, immunologic, and genetic considerations. This is followed by a section, comprising approximately half of the book, on organ transplantation. In areas where clinical experience is scant or nonexistent, the present status of such organ transplants in the laboratory is well documented. Such is the case for heart transplantation, regarding which it was prophetically stated that "the consideration of
The debt and the cash flow of residents: II. And now for the future: the end of HEAL?
Authors: T. L. Walden
Journal: JAMA (1990)

<h3>To the Editor.—</h3> The Health Education Assistance Loan (HEAL), an important source of financial assistance for medical students, has been targeted for elimination by its insurer, the federal government. This action, proposed in the 1991 budget because of the 8.2% default rate and the physician surplus, would be disastrous for medical students. More important, the proposed elimination is based solely on financial concerns and ignores the health care needs of the American people. The rising cost of medical education since abolition of per capita payments in 1974 and of the National Health Service Corps in 1981 has forced more students to rely on HEAL. Of the $642.5 million allocated to medical students for scholarships and aid during the 1987-1988 school year, 13% was generated through the HEAL program.<sup>1</sup> The average 1988 graduate from a private medical school had a debt of $48 068. At my school, Georgetown University, where
ABC of clinical electrocardiography: Atrial arrhythmias
Journal: BMJ (2002)

tion strategies. 16Over the 12 months after randomisation, the total cost of consultations, referrals, investigations, and treatment was on average £404.31 in the endoscopy group compared with only £205.67 in the non-invasive H pylori testing group.Two smaller studies have compared H pylori testing with endoscopy in subgroups of patients with dyspepsia referred for endoscopy. 4 6No differences were found between the two investigation strategies with respect to resolution of dyspepsia, use of drugs, or visits to the general practitioner.Use of endoscopy was reduced by 83% over the two year follow up.
In vivo bradykinin B2 receptor activation reduces renal fibrosis
Authors: Joost P. Schanstra, Eric Neau, Pascale Drogoz, Miguel A. Arevalo Gomez, José Miguel Lopez Novoa, Denis Calise, Christiane Pecher, Michael Bader, Jean-Pierre Girolami, Jean-Loup Bascands
Journal: Journal of Clinical Investigation (2002)

Angiotensin-converting enzyme (ACE) inhibitors reduce the progression of various fibrotic renal diseases both in humans and in animal models. Unilateral ureteral obstruction (UUO) is an animal model of accelerated renal tubulointerstitial fibrosis that is attenuated by ACE inhibition. Although ACE inhibitors increase bradykinin concentrations in addition to their effect on angiotensin II formation, the role of bradykinin in renal fibrosis has not been studied. We show here that genetic ablation (B2–/– mice) or pharmacological blockade of the bradykinin B2 receptor increases UUO-induced interstitial fibrosis in mice, whereas transgenic rats expressing increased endogenous bradykinin show reduced UUO-induced interstitial fibrosis. The increased interstitial fibrosis in B2–/– mice was accompanied by a decreased activity of plasminogen activators (PAs) and metalloproteinase-2 (MMP-2), enzymes involved in ECM degradation, suggesting that the protective effects of bradykinin involve activation of a B2 receptor/PA/MMP-2 cascade. This ability of bradykinin to increase PA activity was confirmed in primary culture proximal tubular cells. Thus, in both mice and rats, bradykinin B2 receptor activation reduces renal tubulointerstitial fibrosis in vivo, most likely by increasing ECM degradation.