tbuckley/cabot-search huggingface dataset:
Abstract 552: The role of the mTORC1/S6K1 signaling pathway in ER-positive breast cancer.
Authors: Anya Sedletcaia, Helen A. Unger, Rose B. Snyder, Marina K. Holz
Journal: Cancer Research (2013)

Abstract The mammalian target of rapamycin complex 1 (mTORC1) is a central signaling node in mediating cellular responses to mitogens, hormones and nutrients. The 40S ribosomal S6 kinase 1 (S6K1) is a conserved serine/threonine protein kinase that belongs to the AGC family of protein kinases, which also includes Akt, RSK and many others. S6K1 is the principal kinase effector downstream mTORC1. S6K1 is sensitive to a wide range of signaling inputs, including growth factors, amino acids, energy levels, and hypoxia. S6K1 relays these signals to regulate a growing list of substrates and interacting proteins in control of oncogenic processes, such as cell growth and proliferation, cell survival and apoptosis, and cell migration and invasion. Growing evidence indicates that there exists a close interaction between the mTORC1/S6K1 pathway and estrogen receptor (ER) signaling. Notably, endocrine resistance is often associated with ligand-independent activation of ERα signaling due to hyperactivation of the mTORC1 signaling pathway, and can be reversed by the mTORC1 inhibitor everolimus in vitro. Several lines of evidence suggest an important role for S6K1 in ER-positive breast cancer. We demonstrated that S6K1 directly phosphorylates ERα on Ser167, leading to activation of its transcriptional activity. While the MAPK-regulated p90 RSK also contributes to phosphorylation of this site, its contribution is early and transient, while the phosphorylation of Ser167 by S6K1 is prolonged and sustained. Intriguingly, we also found that S6K1 expression is estrogenically regulated by a mechanism that involves the transcription factor GATA-3. Thus it appears that S6K1 expression is maintained in two modes: a basal level of expression, typical of normal cells, and an estrogen/ERα-dependent specific upregulation. Therefore, there exists a feed-forward regulatory loop whereby S6K1 activates ERα transcriptional activity, leading to increased expression of S6K1. Our current work aims to uncover the mechanistic details of the transcriptional regulation of S6K1 expression, to delineate signaling cross-talk between mTORC1, S6K1 and ERα, and to asses whether inhibition of S6K1 overexpression and activation affects the development and progression of breast cancer. Citation Format: Anya Sedletcaia, Helen A. Unger, Rose B. Snyder, Marina K. Holz. The role of the mTORC1/S6K1 signaling pathway in ER-positive breast cancer. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 552. doi:10.1158/1538-7445.AM2013-552
Cannulation of the right internal jugular vein is preferable to that of the left internal jugular vein
Authors: J. R. Wendt
Journal: JAMA (1986)

<h3>To the Editor.—</h3> Cannulation of the right internal jugular vein (RIJV) is advantageous when compared with that of the left internal jugular vein (LIJV) in most circumstances. The RIJV is generally larger than the LIJV<sup>1</sup>and hence an "easier target." Furthermore, the course of the RIJV is almost parallel to the superior vena cava, and, hence, the catheter easily traverses to the superior vena cava. The LIJV joins the subclavian vein at approximately a right angle so that, while attempting placement, a catheter will at times hit the inferior wall at the origin of the left brachiocephalic vein and then either turn into the left subclavian vein, turn retrograde into the LIJV, or not advance into the left brachiocephalic vein. Sheep and Guiney<sup>2</sup>suggest that the circuitous course of the LIJV to the superior vena cava leads to greater contact with the catheter and vessel wall and increases
Manuscripts Approved for JNCI, July 1 to August 1, 1970
Journal: JNCI Journal of the National Cancer Institute (1970)

Journal Article Manuscripts Approved for JNCI, July 1 to August 1, 1970 Get access JNCI: Journal of the National Cancer Institute, Volume 45, Issue 3, September 1970, Pages 613–614, https://doi.org/10.1093/jnci/45.3.613-a Published: 01 September 1970
Massachusetts Medical Society
Authors: H. Quimby Gallupe
Journal: New England Journal of Medicine (1950)

AMERICAN MEDICAL ASSOCIATION MEMBERSHIP DUESThe following letter from the secretary and general manager of the American Medical Association will be of interest to all fellows of the Society. To the Secretaries of the Constituent State and Territorial Medical Associations: The House of Delegates of the American Medical Association at its meeting in Washington, D. C., December 6 to 8, 1949, adopted amendments to the By-Laws of the American Medical Association whereby Division One, Chapter II, Tenure of Membership, has been changed to read as follows:Chapter II. — Tenure and Obligations of Membership; DuesSection 1. — When . . .
The Heart Visible: A Clinical Study in Cardiovascular Roentgenology in Health and Disease
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Missing loop.
Authors: R Cawson
Journal: BMJ (1968)

drug that is meant when " betamethasone " is referred to, without qualification, for brevity.I must apologize for this, as it will obviously be confused with another product, betamethasone disodium phosphate (Beta- Corlan, Glaxo), which was not used.It should also be pointed out that while betamethasone (Beta-Corlan) is freely available, Betnovate oral pellets as used in this trial are not available on prescription.-Iam, etc.,
Slipped capital femoral epiphysis
Authors: O. E. Aufranc
Journal: JAMA (1966)

Dr. Aufranc: In an earlier presentation in this series, we discussed an acute slipped capital femoral epiphysis in a 10-year-old girl.<sup>1</sup>This child had had a sudden complete epiphyseal separation. Today's case deals with a much more common type of slipped capital femoral epiphysis, one of gradual onset. Dr. Joseph L. Shaw: A 13-year-old girl complained of limp and gradually progressive pain in the left hip over a three-week period. The case was evaluated in a hospital in another state where x-ray films showed a moderate slip of the left capital femoral epiphysis (Fig 1 and 2). Physical examination showed a painful, sensitive left hip with limitation of flextion to 90° and of internal rotation to 20°. There was 10° of abduction, but pain and involuntary muscle spasm limited other motion. Dr. Aufranc: Dr. Turner will discuss the management of this hip problem which is unique to the adolescent
TRAVEL NOTES FROM SOUTH AMERICA.
Authors: NICHOLAS SENN
Journal: JAMA (1907)

<h3>VIII. MEDICAL SANTIAGO DE CHILE.</h3> My itinerary limited my time in Santiago to five days, and it was fortunate, therefore, that I met Dr. Eduardo Moore, the day after my arrival in the city. I am deeply indebted to him for his kindness and many courtesies, which enabled me to see and learn so much of Santiago's medical men and institutions in such a short time. Santiago has about 400 practicing physicians, with few exceptions Chilean born, but many of them, after graduation from the Medical Department of the University of Santiago, have taken postgraduate courses in Europe, especially in Paris, Berlin and Vienna. As the city has less than 400,000 inhabitants, and more than half of these never expect to pay for medical services, it is not difficult to understand that the average practitioner is not overworked, and that his average annual income is very modest. As in all
What's hot that the other's got
Authors: Janice Higginson
Journal: Thorax (2017)

The aim was find out which of six definitions of bronchopulmonary dysplasia are most predictive of respiratory morbidity or neurosensory deficit, as measured at 18-21 months corrected age.The group then analysed at what gestational age application of the definition would be most accurate.They showed that the existing definition giving the best predictive value was the use of oxygen or respiratory support at 36 weeks gestational age, but that accuracy could be improved by applying this definition at 40 weeks.The application of a single definition that is appropriate to contemporary neonatal medicine will surely be beneficial to the specialty leading to improvements in patient care.internally peer reviewed.
ERYTHROPOIETIC PROTOPORPHYRIA
Authors: LJ. STANOEVA, D. MIOVSKI, P. ČADIKOVSKI
Journal: British Journal of Dermatology (1971)

Summary.— A case of erythropoietic protoporphyria is described. To our knowledge this is the second to be reported in Jugoslavia. The disease started at 3 years of age, with skin photosensitivity. burning and itching of the face and hands. Symptoms and signs were present almost throughout the year, with only short periods of freedom. In recent years the disease had tended to decrease in severity, but lately she has developed some bullous haemorrhagic lesions on the feet. Increased values of RBC protoporphyrin, and to a lesser extent of coproporphyrin, were found. Increased values of faecal protoporphyrin and coproporphyrin were also found. Urinary porphyrins were within normal limits.
New Center Director States "Complementary" Agenda
Authors: C. Marwick
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lead poisoning in missile-silo workers
Authors: J. A. Lambie
Journal: JAMA (1967)

"MINUTEMAN DISEASE," lead poisoning in missile-silo workers, has been reported once before.<sup>1</sup>This is but another addition to the long list of industries and occupations in which lead poisoning is encountered.<sup>2</sup>Despite the fact that lead toxicity is well known and industries employ many means to prevent lead poisoning in workers, instances of lead poisoning continue to occur.<sup>3</sup>Recently two cases of lead poisoning involving Minuteman missile-silo workers were seen during construction of these silos in this area. Their case reports follow, together with a discussion of errors in determination of patients' blood and urine lead values. <h3>Report of Cases</h3><h3>Case 1.—</h3> A 22-year-old man, first seen in the Grand Forks Clinic on March 9, 1966, complained of lower abdominal cramping pain and low back pain of two weeks' duration. He had been constipated for several months. Since July 1965 he had been employed to grind red
Error in Figure
Authors: Ellis Voerman, Vincent Jaddoe, Romy Gaillard
Journal: JAMA (2019)

Bodnar and colleagues further call for reporting absolute risk measures instead of relative risk measures to facilitate interpretation by clinicians and participants.Absolute risk reductions were reported in eTable 9. We agree these risks reductions were relatively small.Any method to define optimal weight gain ranges requires a definition of optimal, which is likely to be arbitrary and subjective.Depending on the definition of clinical relevance, restricting the ranges to stronger protective effects would have resulted in narrower ranges, or might even have failed to identify any optimal gestational weight gain range.The latter would support our conclusion that gestational weight gain is of limited importance with respect to maternal and infant adverse outcomes compared with maternal prepregnancy body mass index.
The Care, Cure and Education of the Crippled Child. A Study of American Social and Professional Facilities to Care for, Cure and Educate Crippled Children. A Complete Bibliography of Literature Bearing on this Subject; and a Complete Directory of Institutions and Agencies Engaged in This Work.
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue
LONDON
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Different changes in expression and function of connexin 26 and connexin 32 during DNA synthesis and redifferentiation in primary rat hepatocytes using a DMSO culture system
Authors: T Kojima, M Yamamoto, C Mochizuki, T Mitaka, N Sawada, Y Mochizuki
Journal: Hepatology (1997)

In the present study, we determined in detail the changes of liver gap junctions, connexin 26 (Cx26), and connexin 32 (Cx32), during DNA synthesis and redifferentiation of hepatocytes in vitro . We used primary rat hepatocytes that expressed the liver gap junction proteins, which were cultured in the medium containing epidermal growth factor (EGF) with 2% dimethylsulfoxide (DMSO) and 10 -7 mol/L glucagon (a DMSO culture system), as we previously reported. In the present cultures, almost confluent hepatocytes cultured in the medium containing EGF with 2% DMSO and 10 -7 mol/L glucagon, underwent a nearly synchronous wave of DNA synthesis induced by the removal of 2% DMSO and 10 -7 mol/L glucagon, and the addition of 10 mmol/L nicotinamide, after which the DNA synthesis was completely re-inhibited by the re-addition of 2% DMSO and 10 -7 mol/L glucagon. During stimulation of DNA synthesis, both Cx26 and Cx32 messenger RNA (mRNAs) in hepatocytes transiently increased in the G1 phase and then markedly decreased before the onset of the S phase, while only Cx26 messenger RNA (mRNA) increased slightly in the S/M phase. Furthermore, before the onset of the S phase, a disappearance of both Cx26 and Cx32 immunoreactivities and gap junction plaques were observed. Gap junctional intercellular communication (GJIC), as measured by lucifer yellow, which indicated the function of Cx32, decreased markedly from before the onset of the S phase. GJIC measured by propidium iodide, which indicated the function of Cx26, decreased from before the onset of the S phase and then increased slightly in the S/M phase. During the re-inhibition after the stimulation of DNA synthesis, Cx32 mRNA, but not Cx26 mRNA, rapidly returned to the pretreatment control level. Cx32 immunoreactivity and gap junction plaques also recovered. However, the recovery of GJIC measured by lucifer yellow was later than that of Cx32 expression. These results indicated the different changes of expression and function of Cx26 and Cx32 in the hepatocytes during stimulation and re-inhibition of DNA synthesis. This culture system should be useful as a model in which to study liver gap junctions during hepatocyte growth and differentiation in vitro .
RECENT STUDIES IN METABOLISM
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Millimetric Misadventure
Authors: Heinrich Lamm
Journal: JAMA (1974)

<h3>To the Editor.—</h3> In a letter about an endotracheal tube (226:675, 1973), Karis said to cut 1.27-cm sections of the tube and later, to pull the catheter back 5.08 cm. Manifestly, Dr. Karis did not mean 1.27 cm and 5.08 cm, which would need to be measured by a caliper ruled at 0.1 mm. So why did he say 1.27 cm and 5.08 cm? The answer is that 1.27 cm is one-half inch, and 5.08 cm two inches. He had probably written "one-half inch" and "two inches," which was editorially converted into centimeters. In daily language, one inch means<i>approximately</i>one inch, and when Karis said "one-half inch" and "two inches," he was approximating. Systems of measurements based on anatomical standards (an ell, a span, a foot, a fingerbreadth, etc) are quite inexact, but in certain situations, its inexactity is its virtue. If you say "two fingerbreadths," the word "approximately"
Modified Syphilis
Authors: J. F. Porter
Journal: BMJ (1874)

MIr. Balfour Browne, in his work on Tue Mledtica _7urispruefence of ]nsanitj', thus concisely refers to the apathy of the legislature in respect to this matter: "The English lawv reftuses to interfere with the liberty of ani iindividual, eveni although hie may be an habitual
Cellular distribution of transcripts for tissue inhibitor of metalloproteinases 1 and 2 in human hepatocellular carcinomas
Authors: H Nakatsukasa, K Ashida, T Higashi, S Ohguchi, S Tsuboi, N Hino, K Nouso, Y Urabe, N Kinugasa, K Yoshida, S Uematsu, M Ishizaki, Y Kobayashi, T Tsuji
Journal: Hepatology (1996)

The cellular distribution of tissue inhibitor of metalloproteinases (TIMP)–1, and TIMP–2 was studied by using in situ hybridization in surgically removed human hepatocellular carcinomas (HCCs) and cholangiocellular carcinomas (CCCs). The purpose of this study was to characterize the protein involvement of TIMPs in the development of HCCs and CCCs. All HCCs and CCCs expressed TIMPs. The distribution of transcripts for TIMPs in the tumors was mostly homogeneous. Expression of TIMP in cancer cells was more intense than that in the surrounding noncancerous liver (either, cirrhosis, chronic hepatitis, or normal), and expression of TIMP–1 was stronger than that of TIMP–2. Expression of TIMPs varied among HCC nodules, but there was no obvious association between the expression level of TIMPs and differentiation stages or invasiveness of the HCCs. Transcripts for TIMPs were clearly demonstrated in the metastatic HCC nodules in the lung. Expression of TIMP–1 CCC was strong, and small nodules of CCC were recognized in the liver. Immunohistochemical study for TIMP–1 revealed a consistent staining of the TIMP protein with the transcripts. In the peritumoral histologically normal liver, which was not infected with either hepatitis B or C virus, expression of TIMP–1 was found in various cell types, but that of TIMP–2 was weak. Expression of TIMP–1 in hepatocytes revealed clear zonal distribution. These results suggest that TIMPs may act on modulating the matrix/tumor interaction and may play an important role in growth and invasion of HCCs and CCCs. Expression of TIMP–1 can be a marker of HCC metastasis to the lung, and also that of the extent of CCC invasion. Furthermore, the consistent expression of TIMPs in many cell types of the noncancerous liver suggests some unknown functional role that must be clarified.
Increase in prostanoid formation in rat liver macrophages (Kupffer cells) by human anaphylatoxin C3a
Authors: G Püschel
Journal: Hepatology (1993)

Human anaphylatoxin C3a increases glycogenolysis in perfused rat liver. This action is inhibited by prostanoid synthesis inhibitors and prostanoid antagonists. Because prostanoids but not anaphylatoxin C3a can increase glycogenolysis in hepatocytes, it has been proposed that prostanoid formation in nonparenchymal cells represents an important step in the C3a-dependent increase in hepatic glycogenolysis. This study shows that (a) human anaphylatoxin C3a (0.1 to 10 μg/ml) dose-dependently increased prostaglandin D2, thromboxane B2 and prostaglandin F2α formation in rat liver macrophages (Kupffer cells); (b) the C3amediated increase in prostanoid formation was maximal after 2 min and showed tachyphylaxis; and (c) the C3a-elicited prostanoid formation could be inhibited specifically by preincubation of C3a with carboxypeptidase B to remove the essential C-terminal arginine or by preincubation of C3a with Fab fragments of a neutralizing monoclonal antibody. These data support the hypothesis that the C3a-dependent activation of hepatic glycogenolysis is mediated by way of a C3a-induced prostanoid production in Kupffer cells. (HEPATOLOGY 1993;18:1516–1521.)