tbuckley/cabot-search huggingface dataset:
Contents
Authors: Douglas Anderson, Anders Heijl, Boel Bengtsson, Leslie Hyman, David Friedman, Steven Hahn, Harry Quigley, Sameer Kotak, Elizabeth Bspharm, Meaghan Kim, Corey Onofrey, Jack Eagan, Constance Okeke, Henry Jampel, Gui-Shuang Ying, Ryan Plyler, Yuzhen Jiang, Jonathan Song, Robert Chang, Rese Knight, William Feuer, Donald Budenz, Mani Baskaran, Rajesh Kumar, Chitra Govindasamy, Hla Htoon, Ching-Yee Wong, Shamira Perera, Tina Frcophth, Ed Wong, Ou Tan, Vikas Chopra, Tzu-Hui Lu, Joel Schuman, Hiroshi Ishikawa, Gadi Wollstein, Rohit Varma, David Huang, Antonio Pinna, Donatella Usai, Leonardo Sechi, Stefania Zanetti, Nelson Jesudasan, Philip Thomas, Jayaraman Kaliamurthy, Grace Richter, Jessica Chung, Stanley Azen, George Kymionis, George Kounis, Dimitra Portaliou, Michael Grentzelos, Alexandra Karavitaki, Efekan Coskunseven, Mirko Jankov, Ioannis Pallikaris, John Chang, Silvania Lau, Raymond Loh, Cordelia Chan, Ei Ti, Li Lim, Ed Kian, Vincent Borderie, Pierre-Yves Boe ¨lle, Olivier Touzeau, ´cile Allouch, Sandrine Boutboul, Marianne Price, Arthur Giebel, Kelly Fairchild, Francis Price, Adam Ross, Mark Jones, Dan Nguyen, Philip Jaycock, W Armitage, Stuart Cook, Stephen Kaye, Shuang Wang, Liang Xu, Jost Jonas, Tien Wong, Tongtong Cui, Yibin Li, Ya Wang, Maureen Maguire, William Christen, Robert Glynn, Emily Chew, Julie Buring, Marion Funk, David Karl, Michael Georgopoulos, Thomas Benesch, Stefan Sacu, Kaija Polak, Gerhard Zlabinger, Ursula Schmidt-Erfurth, Maria Gomez, Francesca Mojana, Dirk-Uwe Bartsch, William Freeman, Katharina Kriechbaum, Franz Prager, Wolfgang Geitzenauer, Christopher Schu ¨tze, Christian Simader, Mark Gillies, Meidong Zhu, Daniel Barthelmes, Edward Hughes, Haipha Ali, Frank Holz, Hendrik Scholl, Peter Charbel Issa
Journal: Ophthalmology (2009)
Epidemic Cholera.
Journal: JAMA (1884)

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Effective Pain Treatment Promotes Activities
Authors: L. Lamberg
Journal: JAMA (2002)

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Hospital Nursery: Factor in Child Development
Journal: JAMA (1964)

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COPPER SULPHATE INSUFFICIENT FOR WATER PURIFICATION.
Journal: JAMA (1906)

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Gunshot Injuries of the Stomach.
Journal: JAMA (2006)

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Memoir on the Digestion and the Assimilation of Amylaceous and Saccharine Matters
Authors: None Mialhe
Journal: BMJ (1846)

treatment was required, and the womian had a verv narrow escape.If the views of M. Mialbe on the action of the ergot be, as I in a great measure regard them, correct, there can be little doubt that the ergot alone might lead to such consequences.
Preliminary results of the effects of beta-hydroxy-beta-methylbutyrate supplementation in patients with liver cirrhosis: a randomized controlled pilot study
Authors: Angelo Bruni, Barbara Lattanzi, Alessio Molfino, Maurizio Muscaritoli, Simone Di Cola, Nicoletta Fabrini, Alessandra Pigliacelli, Manuela Merli
Journal: Journal of Hepatology (2020)
Tyrosine kinase growth factor receptors but not seven-membrane–spanning receptors or phorbol esters activate mitogen-activated protein kinase in rat hepatocytes
Authors: Pere Ginès, Xiaomei Li, Jeffrey L. Zamarripa, Susan E. S. Brown, Eric D. Wieder, Toshikazu Nakamura, Phillip S. Guzelian, Robert W. Schrier, Lynn E. Heasley, Raphael A. Nemenoff
Journal: Hepatology (1995)

The response of rat hepatocytes to hormones and growth factors has been extensively studied with respect to phospholipase regulation and calcium mobilization. However, the mitogen-activated protein (MAP) kinase cascade which integrates signals from a wide variety of extracellular stimuli has not been examined in these cells. Thus, in the present study the pathways leading to activation of MAP kinase in primary cultures of adult rat hepatocytes were investigated. Growth factors acting through tyrosine kinase receptors (epidermal growth factor and hepatocyte growth factor) increased Raf and MAP kinase activity through a protein kinase C and calcium-independent pathway. Agonists acting through seven-membrane-spanning receptors (arginine vasopressin and angiotensin II) increased intracellular calcium concentration but did not stimulate Raf or MAP kinase activity. Arginine vasopressin, however, stimulated MAP kinase activity in rat 1a fibroblasts transfected with the hepatic V1a receptor and in rat aortic vascular smooth muscle cells. Phorbol 12-myristate 13-acetate (PMA) was also unable to stimulate Raf and MAP kinase in hepatocytes in spite of a marked activation of protein kinase C. We conclude that only signals arising from tyrosine kinase receptors are able to activate MAP kinase in hepatocytes. Neither agonists acting through seven-membrane-spanning receptors nor phorbol esters stimulate MAP kinase in hepatocytes. The results suggest that specific cellular components that link seven-membrane-spanning receptors with MAP kinase activation in tissues such as vascular smooth muscle are absent in rat hepatocytes. (HEPATOLOGY 1995; 22:1296–1303.).
FOREIGN CORRESPONDENCE.
Journal: JAMA (1883)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Questions and Answers
Authors: Nancy B. Esterly
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Microfilament-disrupting agent latrunculin A induces and increased number of fenestrae in rat liver sinusoidal endothelial cells: Comparison with cytochalasin B
Authors: F Braet, R De Zanger, D Jans, I Spector, E Wisse
Journal: Hepatology (1996)

This report describes the effect of the actin–disrupting marine toxin latrunculin A on the cytoskeleton and fenestrae of liver endothelial cells (LECs). Fluorescence microscopy and whole mount–transmission electron microscopic preparations of isolated, purified, and cultured LECs showed that latrunculin A, which sequesters actin monomers and depolymerizes actin filaments, caused profound changes in microfilament organization in LECs. Scanning electron microscopic preparations showed that latrunculin A almost doubles the number of fenestrae within 10 minutes, whereas the diameter is only slightly reduced. All new fenestrae possess the earlier described fenestrae–associated cytoskeleton ring. Cytochalasin B, which disrupts the network of actin filaments, principally by capping the fast growing end of actin filaments, produced comparable effects with regard to actin organization and the number and size of fenestrae. After 1 hour of treatment, an equal maximum number of fenestrae was observed for both agents. The effect of latrunculin A was obtained at concentrations about 100 times lower than cytochalasin B. Thus, two agents that alter the state of actin organization in LECs, albeit by different mechanisms, cause the doubling of the number of fenestrae within 10 to 30 minutes. This indicates that the state of assembly of the actin cytoskeleton is important in the numerical dynamics of LEC fenestrae and that the actin cytoskeleton of LECs is probably the main mechanical regulator for sieving between the sinusoidal blood and the parenchymal cells. Latrunculin A represents a new agent in the study of the de novo formation of fenestrae.
Yawning
Authors: Samuel S. Kaufman
Journal: JAMA (1963)

<h3>To the Editor:—</h3> Dr. Montagu (<i>JAMA</i><b>182</b>:732 [Nov 17] 1962) makes these observations on yawning: "The following are the conditions under which yawning occurs: sleepiness, weariness... and boredom." Also, "All these conditions have in common a lowered state of critical consciousness... the state of normal, active awareness of and relatedness to the environment." Dr. Montagu covers only half the nature of the yawn. I would call the yawn he describes the nonmedical or philosophical yawn that is mediated through the cerebral parasympathetic nervous system. The other half of the yawn picture is associated with heightened critical consciousness resulting from an apparent or obscure threat to the physiological and psychological economy. The obvious threat of the narcotic withdrawal syndrome is almost constantly associated with yawning. An example of yawning resulting from an obscure threat is the yawning so frequently present at the onset of a flood of anxiety. The sudden
皮肤病学中的认知和视觉诊断错误
Authors: E.J. Lowenstein, R. Sidlow
Journal: British Journal of Dermatology (2018)

这篇来自美国纽约的评论(第 1 部分,共 2 部分)关注用于进行诊断的启发式技术(“启发式技术”)。解决问题的启发式方法依赖于实际条理而不是逻辑理论。例如“猜估”、“不成文的规则”、“直觉”或仅仅是认出某物。启发式技术通常作为进行诊断的捷径。医生诊断牛皮癣的一种方法是根据经验:经验丰富的医生能立即发现牛皮癣,因为他们见过很多牛皮癣;他们不需要每次都在每种特征上打勾。如果诊断结果不是直接明显的,那么他们可能会转而采用一种更符合逻辑的方法,比如将一组临床症状整合在一起。第一种方法更简单、更快,但更容易出错,尤其是缺乏经验的人使用时。因此,缺乏经验的人可能不得不使用第二种方法,而它有时是费力的。我们经常使用两种方法的混合,但我们两种方法都会犯错误:在医学上,有一部分一直出现的不正确诊断水平可能要归因于我们自己的思维过程。列出了四十多种启发式技术。例如,如果医生已经做出了诊断,他们可能会过早地停止治疗,忽略更细微的信息,并且未能考虑其他的方法(“锚定启发法”)。对于皮肤科医生来说,包括颜色、部位、形状和质地在内的启发式技术是很重要的,但 12 幅图片说明了它们可能如何被引入歧途。人类利用纯视觉信息时会做得更好,这对于放射学家和组织病理学家来说似乎是个好消息。
Modern Insanity.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PWE-081 Clinical and Diagnostic Value of 96 Hours Wireless Reflux Monitoring Off/On PPIs
Authors: I Koumoutsos, C Chia, I Nasr, I Miah, J Jafari, T Wong
Journal: Gut (2016)

<h3>Introduction</h3> Prolonged catheter-free pH monitoring with Bravo capsule up to 96 hours has become possible and enables extended physiological evaluation of gastroesophageal reflux disease (GERD) and response to therapeutic interventions. Aim of the present study was to determine the feasibility of 96 hrs recordings using Bravo capsule that would encompass time periods both off and on therapy with Proton Pump Inhibitors (PPIs). <h3>Methods</h3> A total of 432 patients reporting symptoms of GERD refractory to conventional therapy underwent 96 hours of Bravo capsule recordings. Patients identified with abnormal acid exposure during the 1st 48 hrs of recordings (off PPIs) underwent the 2nd 48 hrs of recording on twice daily PPIs. The parameters subjected to analysis were percent of time ph &lt; 4 (total, upright, supine, postprandial), number of refluxes, symptoms reported by the patients and their association with acid reflux (SI+). <h3>Results</h3> 132/436 (30.3%) of patients had abnormal acid exposure in the 1st 48 hrs (70 males, mean age 49, range 17–81 years) and the second 48 hrs of recordings was performed on PPIs.98/132 (74.2%) had normal acid exposure on PPIs whereas 34/132 (23.5%) had abnormal acid exposure despite high dose of PPIs. The overall number of symptoms reported in the 2nd 48 hrs was reduced by 68.4% (responsive 76.7% vs refractory 49.9%, p &lt; 0.05). The number of these symptoms that were actually associated with acid reflux events was reduced by 57.5% (responsive 43.9% vs refractory 39%, p = 0.094). In patients refractory to PPIs acid reflux in upright position was identified in 23/34 (67.7%), supine in 18/34 (52.9%) and in both positions in 8/34 (23.5%). Abnormal number of refluxes was identified in (27/34)79.5% of the patients. In total 355 symptoms were recorded by patients during the 96 h of recording. 200/355 (56.3%) of these symptoms were not related to acid reflux (SI-). Prolonged Bravo recordings on PPIs identified 16/355 (4.5%) additional SI(+) symptoms that were SI(-) in the 1st 48 hrs. 139/355 (39.15%) of symptoms were SI(+) in the 1st48h of recordings and 43/139 (30.93%) remained SI(+) despite high dose of PPIs. In patients refractory to PPIs 25/41 had SI(+) symptoms whereas in the responsive 35/98 patients had SI(+) symptoms.Refractory GERD to PPIs was significantly correlated with positive symptom association (SI+) for chest pain (p = 0.01), heartburn (p = 0.043), and vomiting (p = 0.015). <h3>Conclusion</h3> Extended pH recording improves the detection of abnormal acid reflux. Combined off and on PPI therapy pH testing provides additional information which can be helpful in the management of patients with PPI refractory GERD. <h3>Disclosure of Interest</h3> None Declared
Whole-Exome Sequencing Identifies Recurrent Mutations of BCOR in Acute Myeloid Leukemia with Normal Karyotype
Authors: Brunangelo Falini, Vera Grossmann, Enrico Tiacci, Antony Holmes, Alexander Kohlmann, Maria Paola Martelli, Wolfgang Kern, Ariele Spanhol-Rosseto, Vladimir Trifonov, Susanne Schnittger, Claudia Haferlach, Renato Bassan, Victoria A Wells, Orietta Spinelli, Laurent Farinelli, Alessandro Rambaldi, Laura Pasqualucci, Raul Rabadan, Torsten Haferlach
Journal: Blood (2011)
Aerospace Medicine
Authors: R B Rayman
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal