tbuckley/cabot-search huggingface dataset:
Abstract CT152: A Phase II pilot trial of nivolumab (N) + albumin bound paclitaxel (AP) + paricalcitol (P) + cisplatin (C) + gemcitabine (G) (NAPPCG) in patients with previously untreated metastatic pancreatic ductal adenocarcinoma (PDAC)
Authors: Erkut H. Borazanci, Gayle Jameson, Ronald Lee Korn, Lana Caldwell, Karen Ansaldo, Kristin Hendrickson, Katie Marceau, Kevin Gosselin, Daniel D. Von Hoff
Journal: Cancer Research (2019)

Abstract Background: Effective therapy for the treatment of PDAC remains one of the greatest unmet oncology clinical needs. The addition of C to G and AP has shown promising clinical data in a previously reported study [J Clin Oncol 35, 2017 (suppl 4S; abstract 341)]. In preclinical work, vitamin D (Vit D) analog therapy decreases myeloid derived suppressor cells and regulatory T cells, favorably influencing the immune environment. This trial combines AP/C/G with Vit D analog P and the anti-PD-1 antibody N as a combination therapy for patients with previously untreated metastatic PDAC. This trial evaluates the efficacy and safety of NAPPCG in that patient population (NCT02754726). Methods: Eligibility criteria include Stage IV PDAC, no prior chemotherapy for systemic disease, KPS ≥ 70, and measurable disease. Doses are AP 125 mg/m2 undiluted, G 1000 mg/m2 in 250 ml of normal saline (NS), each infused over 30 minutes with C 25 mg/ m2 in 500 ml of NS infused over 60 minutes on days 1, 8, 22, and 29 of a 42-day cycle. N is given at a fixed dose of 240 mg as a 60 minute infusion on days 1, 15, and 29. P is given at a fixed dose of 25 µg IV twice weekly. Primary objective is to determine the efficacy of the combination for patients with previously untreated metastatic PDAC through determining CR, ORR, PFS, and OS. The secondary objective is to evaluate safety in patients with previously untreated metastatic PDAC. Results: Trial was initiated May 2016 and 25 patients have been enrolled in the study and 24 are evaluable (baseline and ≥1 follow up CT scan). Most common drug-related grade (Gr) 3-4 adverse events (AE’s), are thrombocytopenia 76% (gr 3 = 44%, gr 4 = 32%) with no serious bleeding events, anemia 44% (gr 3 = 44%, gr 4 = 0%), and colitis 12% (gr 3 = 12%, gr 4 = 0%). By RECIST 1.1 criteria, response is 19 PR, 2 SD, 2 PD, yielding an 83% ORR. Median PFS is 8.17 months. Median OS is 15.3 months. Conclusions: Although a small study, the high response rate is encouraging. The clinical trial is now being expanded. Supported by grants from the Seena Magowitz Foundation, Mattress Firm, Bristol Myers Squibb, and SU2C. Citation Format: Erkut H. Borazanci, Gayle Jameson, Ronald Lee Korn, Lana Caldwell, Karen Ansaldo, Kristin Hendrickson, Katie Marceau, Kevin Gosselin, Daniel D. Von Hoff. A Phase II pilot trial of nivolumab (N) + albumin bound paclitaxel (AP) + paricalcitol (P) + cisplatin (C) + gemcitabine (G) (NAPPCG) in patients with previously untreated metastatic pancreatic ductal adenocarcinoma (PDAC) [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr CT152.
Nasal Siphon Syringe.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
DIPHTHERIA MORTALITY IN THE LARGE CITIES OF THE UNITED STATES
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lesions of the sacrum. Differential diagnosis and radiological evaluation
Authors: M. L. Turner
Journal: JAMA (1981)

PRIMARY lesions of the sacrum are relatively uncommon. They frequently are accompanied by nonspecific symptoms such as low back pain and pelvic pressure. Large lesions may involve the sacral nerves and are often palpable on rectal examination. The diagnosis of an early lesion may prove difficult when vague symptoms are accompanied by subtle radiological findings. The curvilinear shape of the sacrum makes it difficult to evaluate on standard anteroposterior projections. A helpful adjunct is the distorted view of the sacrum, which is obtained with the tube angled 15 degrees cephalad and with the patient's hips flexed. This stretches or straightens out the sacrum, enhancing visualization. On frontal projections, the symmetry and osseous integrity of the sacral foramina should be carefully observed. Fecal material and bowel gas frequently overlie and obscure the sacrum, particularly when the sacral nerves are involved<sup>1</sup>(Fig 1, top left). The lateral view demonstrates the anterior border
Abstract 1527: Lipopolysaccharides Up-regulate Kir6.1/SUR2B Channel Expression And Enhance Vascular K <sub>ATP</sub> Channel Activity Through NF-κB And PKA Pathways
Authors: Weiwei Shi, Zhongying Wu, Ningren Cui, Shuang Zhang, Daling Zhu, Chun Jiang
Journal: Circulation (2008)

Septic shock, characterized by vasodilatation and hyporeactivity to vasoconstrictors, is a major cause of death. Recent studies have shown that an ATP-sensitive K + (K ATP ) channel plays a critical role in septic susceptibility. However, the mechanisms underlying K ATP channel responses to sepsis are still unclear. Thus, we performed these studies to demonstrate how the vascular K ATP channel changes its activity and expression with an exposure to lipopolysaccharides (LPS), a major septic pathogen. In isolated rat mesenteric arterial rings, phenylephrine (PE) induced concentration-dependent vasoconstriction. At the maximum effect, pinacidil, a selective K ATP channel opener, relaxed the rings almost completely. The PE response was almost completely lost after a pretreatment with LPS (1μg/ml) overnight. The LPS treatment produced hyperpolarization of acutely dissociated aortic smooth myocytes. Consistently, LPS treatment augmented K ATP channel activity via increasing channel density in plasma membranes in these cells. Quantitative PCR analysis showed that LPS stimulated Kir6.1 and SUR2B expressions in a dose-dependent manner. LPS in 0.01 μg/ml raised Kir6.1 mRNA expression by ~1.8-folds (P&lt;0.01, n=8). Stronger effects were seen with higher concentrations (by 2.5 and 3.0-folds with 0.1 and 1 μg/ml LPS, respectively). SUR2B expression also increased dose-dependently, though to a less degree. The LPS-induced expression of Kir6.1 and SUR2B subunits was suppressed by actinomycin D (2 μg/ml) and actidione (2 μg/ml), suggesting both transcriptional and translational mechanisms are involved. The effect of LPS on Kir6.1 and SUR2B expression was diminished by a pretreatment with the selective NF-κB inhibitors dimethyl fumarate (0.1 mM) or pyrrolidine dithiocarbamate (0.1 mM). Furthermore, the specific PKA blockers Rp-cAMP (100 μM) or KT5720 (1 μM) suppressed LPS-induced Kir6.1 and SUR2B expression. These results therefore suggest that K ATP channel activity is enhanced with LPS exposure leading to hyperpolarization of vascular smooth muscles and vasodilation, and such an effect involves up-regulation of Kir6.1 and SUR2B expressions, in which NF-κB and PKA-dependent intracellular signaling pathways may play a role.
Neonatal screening for phenylketonuria. I. Effectiveness
Authors: N. A. Holtzman
Journal: JAMA (1974)

Programs for the detection of phenylketonuria (PKU) were evaluated by surveys of health departments and PKU clinics. Effectiveness was measured by determining (1) the proportion of live births screened, (2) the occurrence of PKU infants missed by screening (false-negatives), (3) the proportion of presumptive positives in whom a diagnosis of PKU was confirmed by follow-up studies, and (4) the interval between screening test and follow-up. More than 10% of infants with PKU are either not being screened or are not being detected by screening. Infants with PKU who are screened on the first 3 days of life are more likely to be missed than those screened later. The infants in whom a diagnosis of PKU was confirmed constituted only 5.1% of all infants with presumptive positive screening tests. Programs differ greatly in the incidence of presumptive positive tests and in the time necessary to follow up positive tests. (<i>JAMA</i>229:667-670, 1974)
Hair concentrations of nicotine and cotinine in women and their newborn infants
Authors: C. Eliopoulos
Journal: JAMA (1994)

<h3>Background.</h3> —To date, no biological markers have been identified that can predict the extent of fetal exposure to the toxic constituents of cigarette smoke. A variety of xenobiotic agents have been shown to accumulate in growing hair. <h3>Patients and Methods.</h3> —We measured maternal and neonatal hair concentrations of nicotine and cotinine in 94 mother-infant pairs. Mothers who were active smokers, nonsmokers, and passive smokers and their infants were included. <h3>Results.</h3> —Mothers who were active smokers (n=36) had mean (SEM) hair concentrations of 19.2 (4.9) ng/mg for nicotine and 6.3 (4.0) ng/mg for cotinine, significantly higher than concentrations in nonsmokers (n=35) (1.2 [0.4] ng/mg for nicotine and 0.3 [0.06] ng/mg for cotinine,<i>P</i>&lt;.0001). Infants of smokers had mean hair concentrations of 2.4 (0.9) ng/mg for nicotine (range, 0 to 27.3 ng/mg) and 2.8 (0.8) ng/mg for cotinine (range, 0 to 12.2 ng/mg), significantly higher than concentrations in infants of nonsmokers (0.4 [0.09] ng/mg for nicotine and 0.26 [0.04] ng/mg for cotinine,<i>P</i>&lt;.01). Mothers with passive smoke exposure and their infants (n=23) had significantly higher hair concentrations of nicotine (3.2 [0.8] ng/mg for mothers and 0.28 [0.05] ng/mg for infants) and cotinine (0.9 [0.3] ng/mg for mothers and 0.6 [0.15] ng/mg for infants) than nonsmoking mothers and their infants (<i>P</i>&lt;.01). There was a significant correlation between maternal and neonatal hair concentrations of nicotine (r=.49,<i>P</i>&lt;.001) or cotinine (r=.85,<i>P</i>=.0001). <h3>Conclusions.</h3> —This is the first biochemical evidence that infants of passive smokers are at risk of measurable exposure to cigarette smoke. Hair accumulation of cigarette smoke constituents reflects long-term systemic exposure to these toxins and therefore may be well correlated with perinatal risks. (<i>JAMA</i>. 1994;271:621-623)
WHY SHOULD NOT LADIES TAKE TO PHARMACY
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pathogenesis of cancer‐associated thrombosis
Authors: Nigel Mackman
Journal: HemaSphere (2018)

Program in Thrombosis and Hemostasis, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA This is an open access Abstract Book distributed under the Attribution-NonCommercial-NoDerivs (CCBY-NC-ND), which allows third parties to download the abstracts and share them with others as long as they credit the author and the abstract book, but they cannot change the content in any way or use them commercially. http://creativecommons.org/licenses/by-nc-nd/4.0
DENIAL OF DEATHS FROM DELAYED RADIOACTIVITY OF ATOMIC BOMB
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
NOTES
Authors: A. Meining, S. von Delius
Journal: Endoscopy (2008)

Scientific interest in natural-orifice transluminal endoscopic surgery (NOTES) continues to increase. A record number of abstracts on NOTES were presented at this year’s Digestive Diseases Week. A search for “NOTES” revealed 104 hits among this year’s submitted abstracts. In total, 78 abstracts related to NOTES procedures, of which 5 covered video case presentations. The remaining 73 reports have been classified under “Access and closure” (n = 25), “Indications for NOTES” (n = 19), “Training, education and health economics” (n = 6), “Infection and immunity” (n = 5), and “NOTES procedures in humans” (n = 6). Twelve abstracts have been classified under “New devices and tools.” The number of abstracts devoted to NOTES was thus double the number in DDW 2007. However, NOTES procedures are still determined by basic research in vitro or in animal models. Clinical applications in humans are very few. Nevertheless, many new aspects have been highlighted, and useful devices have been developed and studied that have the potential to facilitate not only NOTES but also endosurgery in general. The question will be which techniques, indications, and devices will disappear and which will become integrated into clinical practice.
Late Results of Exsanguinotransfusion in 50 Infants with Severe Neonatal Blood Incompatibility
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Massachusetts Medical Society
Authors: Harriet L. Hardy
Journal: New England Journal of Medicine (1957)

TOXIC HAZARDS*Current Hazards of Toxic Beryllium Compounds†Many physicians have become aware, through clinical experience, that certain compounds of beryllium can produce a systemic disease, beryllium poisoning. Because pulmonary involvement causes the syndrome usually present, differential diagnosis of beryllium disease from miliary tuberculosis and Boeck's sarcoid is often a problem. There may be a delay between exposure to toxic beryllium compounds and the appearance of signs of disease of as long as ten years, a fact that adds to the problem of diagnosis. As clinical knowledge of beryllium poisoning increases, it has become established that there may be miliary . . .
A propensity score analysis of radical cystectomy versus bladder-sparing trimodal therapy in the setting of a multidisciplinary bladder cancer clinic.
Authors: Girish S. Kulkarni, Thomas Hermanns, Yanliang Wei, Bimal Bhindi, Raj Satkunasivam, Peter Bostrom, Cynthia Kuk, Kathy Li, Annette Erlich, Arnoud J. Templeton, Srikala S. Sridhar, Theodorus van der Kwast, Peter W. M. Chung, Robert G. Bristow, Michael F. Milosevic, Padraig Richard Warde, Neil Eric Fleshner, Michael A.S. Jewett, Shaheena Bashir, Alexandre Zlotta
Journal: Journal of Clinical Oncology (2017)

e16003 Background: Multidisciplinary management improves complex treatment decision making in cancer care, but its impact for bladder cancer (BC) has not been documented. While radical cystectomy (RC) is currently viewed as the standard of care for muscle-invasive bladder cancer (MIBC), radiotherapy-based, bladder-sparing trimodal therapy (TMT) combining transurethral resection of bladder tumor, chemotherapy for radiation sensitization and external beam radiotherapy has emerged as a valid treatment option. In the absence of randomized studies, we compared the oncological outcomes between patients managed by RC or TMT using a propensity-score matched cohort analysis. Methods: Patients seen in our multidisciplinary bladder cancer clinic (MDBCC) from 2008 to 2013 were retrospectively reviewed. Those who received TMT for MIBC were identified and matched (for gender, cT and cN stage, ECOG status, Charlson comorbidity score, treatment date, age, CIS, hydronephrosis) using propensity scores, to patients who underwent RC. Overall survival and disease-specific survival (DSS) were assessed with Cox Proportional hazards modeling and competing risk analysis, respectively. Results: 112 patients with MIBC were included after matching, 56 treated with TMT and 56 by RC. Median age was 68.0 years and 29.5% were cT3/cT4. At a median follow up of 4.51 years, there were 20 (35.7%) deaths (13 from BC) in the RC group and 22 (39.3%) deaths (13 from BC) in the TMT group. 5 year DSS was 73.2% and 76.6%, in the RC and TMT groups, respectively (p = 0.49). Salvage cystectomy was performed in 6/56 TMT patients (10.7%). Conclusions: In the setting of a MDBCC, TMT yielded survival outcomes similar to matched RC patients. Appropriately selected MIBC patients should be offered the opportunity to discuss various treatment options including organ-sparing TMT.
Order, 19 May 1982, in the matter of the American Medical Association, the Connecticut State Medical Society, the New Haven County Medical Association, Inc
Journal: JAMA (1982)

The text of a Federal Trade Commission cease-and-desist order against the American Medical Association (AMA) is reprinted. The order prohibits the AMA from restricting or declaring unethical the advertising of physician services or the participation of physicians in health maintenance organizations.
Aspirin and analgesic nephropathy
Authors: R. D. Emkey
Journal: JAMA (1982)

To assess the effects of long-term aspirin ingestion on renal function, we studied all of the patients at the Massachusetts General Hospital Arthritis Clinic who had been taking aspirin continuously for ten or more years. Aspirin ingestion was documented by multiple, random, unannounced blood salicylate levels. Most of these 46 patients had seropositive rheumatoid arthritis. All creatinine and BUN levels were normal. Maximum recorded specific gravities were greater than 1.019 in 43 of 46 patients. These data suggest that long-term salicylate ingestion does not cause renal damage. (<i>JAMA</i>1982;247:55-57)