tbuckley/cabot-search huggingface dataset:
From the authors
Authors: J. R. Curtis
Journal: European Respiratory Journal (2009)

Most discoveries in empirical finance are false, as a consequence of selection bias under multiple testing. Although many researchers are aware of this problem, the solutions proposed in the literature tend to be complex and hard to implement. In this article, the author reduces the problem of selection bias in the context of investment strategy development to two sub-problems: determining the number of essentially independent trials and determining the variance across those trials. The author explains what data researchers need to report to allow others to evaluate the effect that multiple testing has had on reported performance. He applies his method to a real case of strategy development and estimates the probability that a discovered strategy is false. <b>TOPICS:</b>Statistical methods, performance measurement
Newborn Screening
Authors: Megan A. Moreno
Journal: JAMA Pediatrics (2016)

Jeffrey R. Botkin, MD, MPH; Erin Rothwell, PhD; Rebecca A. Anderson, RN, PhD; Nancy C. Rose, MD; Siobhan M. Dolan, MD, MPH; Miriam Kuppermann, PhD, MPH; Louisa A. Stark, PhD; Aaron Goldenberg, PhD; Bob Wong, PhD
One Death Linked With Donor Blood That Got Past West Nile Virus Tests
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Paradoxes
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
POISON IVY, OAK AND SUMAC
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Neurology, Minneapolis
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Polymyxin B-immobilized fiber improves systemic hemodynamics in patients with severe sepsis and septic shock via the attenuation of nitric oxide Yoji Kato, Yasuhiko Matsuura, Yoshiyuki Kijima, Kazuhiko Hashimura, Takenori Yasuda, Tetsuya Ueda, Isao Mori, Masafumi Kitakaze, Tetsuo Minamino, Tsunehiko Kuzuya, Masatsugu Hori. Cardiovascular Division, Ishinkai Yao General Hospital, Osaka Yao, Japan, Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, …
Journal: Journal of the American College of Cardiology (2001)
Pulmonary edema following direct current cardioversion for atrial arrhythmias
Authors: J. Budow
Journal: JAMA (1971)

Three patients developed acute pulmonary edema shortly after direct current cardioversion for atrail arrhythmias. All patients had marked left ventricular enlargement and evidence of left ventricular failure prior to cardioversion. Each patient received a single low-intensity shock. Two patients recovered, but the third failed to respond to intensive medical treatment for pulmonary edema, and death resulted. Cardioversion may result in critical depression of left ventricular function and may not be indicated for the treatment of atrial arrhythmias in the presence of severe disease of the left ventricle.
Collagen type XVIII is associated with platelet count and meld score in patients with trans-jugular intrahepatic portosystemic shunt
Authors: Ida Villesen, Mette Juul Nielsen, Jennifer Lehmann, Tina Manon-Jensen, Robert Schierwagen, Christian Jansen, Michael Praktiknjo, Diana Leeming, Morten Karsdal, Jonel Trebika
Journal: Journal of Hepatology (2020)
Dyslexia
Authors: Bennett A. Shaywitz, Stephen G. Waxman
Journal: New England Journal of Medicine (1987)

The disorder we now call "dyslexia" has historical roots that can be traced back to the late 19th century, when the notion of a specific syndrome involving the inability to read in spite of normal vision evolved. Early reports began with Kussmaul's description of "word blindness" in 1877 and focused initially on indications of an acquired inability to read among adults.1 The term "dyslexia" was first used in 1887 by Berlin, but it was the Scottish ophthalmologist Hinshelwood1 who differentiated complete word blindness, alexia, from partial impairment or dyslexia.The report by Orton in 1925 on word blindness in schoolchildren . . .
Chronic Osteomyelitis
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Frequency of 'chronic active Epstein-Barr virus infection' in a general medical practice
Authors: D. Buchwald
Journal: JAMA (1987)

Twenty-one percent of 500 unselected patients, aged 17 to 50 years, seeking primary care for any reason were found to be suffering from a chronic fatigue syndrome consistent with "chronic active Epstein-Barr virus (EBV) infection." They had been experiencing "severe" fatigue, usually cyclic, for a median of 16 months (range, six to 458 months), associated with sore throat, myalgias, or headaches; 45% of the patients were periodically bedridden; and 25% to 73% reported recurrent cervical adenopathy, paresthesias, arthralgias, and difficulty in concentrating or sleeping. The patients had no recognized chronic "physical" illness and were not receiving psychiatric care. While antibody titers to several EBV-specific antigens were higher in patients than in age- and sex-matched control subjects, the differences generally were not statistically significant. A chronic fatigue syndrome consistent with the chronic active EBV infection syndrome was prevalent in our primary care practice. However, our data offer no evidence that EBV is causally related to the syndrome. Indeed, we feel that among unselected patients seen in a general medical practice currently available EBV serologic test results must be interpreted with great caution. (<i>JAMA</i>1987;257:2303-2307)
Dental Infections. In two volumes.
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effects of Metoprolol CR in Patients With Ischemic and Dilated Cardiomyopathy
Journal: Circulation (2000)

Background —Metoprolol provides clinical benefits in patients with congestive heart failure (CHF). In this study, we investigated the effects of controlled-release metoprolol (metoprolol CR) on clinical status, on left ventricular (LV) volumes and function, and on neurohumoral activation in a large number of patients with CHF of mixed causes. Methods and Results —Four hundred twenty-six patients with symptomatic CHF were randomized to receive metoprolol CR or placebo for 24 weeks. Metoprolol CR did not affect 6-minute walk distance, New York Heart Association functional class, or quality of life. However, there was a significant improvement in measures of LV function with an attenuation in the increase in LV end-diastolic (+23±65 mL [placebo] versus +6±61 mL, P =0.01) and LV end-systolic (+19±55 mL [placebo] versus −2±51 mL, P &lt;0.001) volumes after 24 weeks of therapy. LV ejection fraction was unchanged (−0.05% or −0.005) in the placebo group but increased by 2.4% in the metoprolol CR–treated patients ( P =0.001). Patients receiving metoprolol CR had a greater decrease in angiotensin II ( P =0.036) and renin ( P =0.032) levels but an increase in N-terminal atrial natriuretic peptide and brain natriuretic peptide levels ( P &lt;0.01). There were fewer deaths in the group receiving β-blockers (3.4% versus 8.1%), and there was a similar number of patients experiencing the composite outcomes of death or any hospitalization. Conclusions —When added to ACE inhibitors, angiotensin II receptor antagonists, or both, the use of metoprolol CR improves ventricular function, reduces activation of the renin-angiotensin systems, and results in fewer deaths.
Incorrect Dosage
Journal: JAMA (1981)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
OC-158 Endogenous production of antibiotics by mesenchymal stem cells and the potential value in crohn's fistula healing
Authors: L Meran, M Garavaglia, S Heeb, R Bayston, B Richards, W Ashraf, F Rose, K Shakesheff, C Hawkey
Journal: Gut (2012)

<h3>Introduction</h3> Potent effects of human mesenchymal stem cells (MSCs) on immune responses have been demonstrated in vitro studies and animal models, encouraging further investigations into their clinical value. Studies of MSCs in fistula healing have emphasised the immunosuppressive mechanisms of action however, there has been little focus on their antibacterial activity in this setting. We report here on the antibacterial effects of MSCs against Adherent Invasive <i>Escherichia coli</i> (AIEC), reference strain LF82. <h3>Methods</h3> Cultured human bone marrow derived MSCs were plated at a density of 5×10<sup>4</sup> cells per square centimetre in 24 well plates and allowed to adhere overnight. Confluent MSCs were preincubated for 1-day with fresh culture medium alone or medium supplemented with 1 ng/ml TNFα. Cells of passage numbers 4–9 were co-cultured with a calculated 300 Colony Forming Units of AIEC strain LF82 and incubated for 6 h in a humidified CO<sub>2</sub> incubator. Aliquots of the infected medium were taken from each well and plated on LB-agar plates and colonies were counted after overnight incubation. Comparisons were made with aliquots from inoculated wells containing cells that were pre-stimulated with TNFα, in addition to wells that did not contain mesenchymal stem cells. Data analyses were performed using the SPSS statistical package (V.19.0). <h3>Results</h3> Each of the wells under test conditions was inoculated with 379±98 CFU at the start of the co-culture time period. In the absence of mesenchymal stem cells, the number of LF82 CFUs in mesenchymal stem cell culture medium had risen to a mean (±SD) of 1780±319 [n=3], after 6 h. In the presence of passage-4 MSCs, the number of LF82 CFU was significantly reduced by 81.2%, to 335±61 [n=3] (p&lt;0.05). When MSCs were prestimulated with TNF, there was a further reduction of CFU levels to 15±6 [n=3]. When cells of higher of passage numbers were used, the effects both in the presence and absence of TNF prestimulation diminished such that by passage-8, there was no significant inhibition of bacterial growth. <h3>Conclusion</h3> The antibacterial properties of MSCs alongside their tissue regenerative potential make them ideal candidates for use in therapeutic strategies for fistula healing. This study demonstrates that in a proinflammatory environment, MSCs enhance bacterial clearance of AIEC. These findings encourage further evaluation of the antimicrobial effector function of MSCs against other strains suspected to participate in the pathogenesis of Crohn9s disease. <h3>Competing interests</h3> None declared.
Update: Trends in AIDS Incidence—United States, 1996
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Corrections
Authors: Edward Kasarskis
Journal: The Lancet Neurology (2016)

restriction was imposed during a period of 24 weeks, and by the end of the experiment the participants' bodyweight was, on average, 75% of their initial bodyweight.Relevant to ALS, these men had loss of lean body mass, muscle atrophy, weakness, fatigue, reduced basal metabolic rate, and reduced endurance.These fi ndings 9 indicate that chronic inadequate caloric intake by itself, in the absence of any neurodegenerative disease, can cause muscle atrophy and weakness.Although this was an extreme experiment, it suggests that in patients with ALS, the physiological eff ects of nutritional insuffi ciency are likely to be additive to the weakness caused by neurogenic muscle atrophy (in the Minnesota starvation experiment 9 participants' weakness and muscle atrophy was completely reversible with controlled refeeding).Ahmed and colleagues 3 review the various nutritional and metabolic changes that occur across the ALS-FTD clinical spectrum.In patients with ALS, FTD, or both, many homoeostatic mechanisms interact to regulate appetite and metabolism.The authors 3 summarise the relevant work in this area and describe some of the complexities involved.In essence, the extremes of their argument involve two, not necessarily exclusive, hypotheses.One hypothesis postulates that the diff erent phenotypes of ALS and FTD have, as part of them, an intrinsically altered metabolic or regulatory status.The other hypothesis considers metabolic changes as an expected result of the functional impairments caused by neurodegeneration.This second concept probably has more experimental support.In this view, the ALS phenotype results from degeneration of cortical and spinal motor neurons causing neurogenic atrophy, weakness, and spasticity, which directly lead to reduced food intake and energy imbalance.In the case of the behavioural variant of FTD, neurodegeneration of aff ected networks that regulate behaviour and appetite results in behavioural disinhibition, hyperphagia, and there fore energy imbalance due to increased energy intake.How energy imbalance feeds back to accelerate the process of central neurodegeneration is yet to be established.Answers to these questions will have substantial theoretical and practical implications, and, more importantly, this research emphasises the need to control variables related to energy intake and expenditure in future clinical drug trials.
Commentaire de travail de van Vilsteren FGI et al., pp. 516
Journal: Endoscopy (2013)

See also: Predictive factors for initial treatment response after circumferential radiofrequency ablation for Barrett’s esophagus with early neoplasia: a prospective multicenter studyEndoscopy 2013; 45(07): 516-525DOI: 10.1055/s-0032-1326423
Reports to the Membership
Journal: American Journal of Psychiatry (2020)

The following are edited/abbreviated versions of the annual reports of the APA Secretary, Treasurer, CEO and Medical Director, Speaker, and Speaker-Elect and the chairpersons of the APA Committee on Bylaws, Membership Committee, Committee of Tellers, and Elections Committee. The full reports were presented at the APA Virtual Spring Highlights Meeting, April 25-26, 2020.