tbuckley/cabot-search huggingface dataset:
Comparison of medical costs among patients using adalimumab and infliximab: a retrospective study (compairs)
Authors: D. A. Sussman, N. Kubiliun, J. Chao, P. M. Mulani, C. A. Gillis, M. Yang, M. Lu, M. T. Abreu
Journal: Gut (2011)

<h3>Introduction</h3> Anti-tumour necrosis factor (anti-TNF) medications have never been compared in a direct fashion under real-world circumstances. The purpose of this study was to compare healthcare utilisation and costs using insurance data for patients with Crohn9s disease (CD) who newly initiated anti-TNF therapy with adalimumab (ADA) or infliximab (IFX). <h3>Methods</h3> Patients with ≥2 diagnoses of CD (ICD-9-CM: 555.XX) who initiated ADA or IFX therapy between January 2000 and March 2009 were identified from the Medstat MarketScan database. Patients had to be continuously enrolled at least 6 months before and after anti-TNF initiation. Patients with prior biologic therapy (ie, anti-TNF or natalizumab) or colitis (ICD-9-CM: 556.x) were excluded. ADA and IFX groups were matched 1:1 using a propensity score stratified by age, residence, inpatient visit utilisation and steroid use at baseline. The primary endpoint was 6-month direct cost of healthcare. The secondary endpoints compared healthcare utilisation between groups. <h3>Results</h3> After propensity matching, demographic, clinical and healthcare utilisation characteristics were similar between the ADA (n=623) and IFX (n=623) groups at baseline. During the 6-month interval following anti-TNF initiation, healthcare costs were significantly lower for ADA compared with IFX therapy (table 1). Both all-cause and CD-related hospitalisation decreased for both ADA and IFX groups (not shown). Emergency department (ED) use and hospitalisation in the 6-month follow-up period were similar between groups. <h3>Conclusion</h3> In this real-world analysis of patients with CD who newly initiated with ADA or IFX, ADA-treated patients had significantly lower healthcare costs. Hospitalisation and ED utilisation were similar between groups.
Recycling
Authors: Richard Blakely
Journal: Annals of Internal Medicine (2014)

Letters20 May 2014RecyclingRichard Blakely, MDRichard Blakely, MDFrom Memorial Hermann Physician Network (MHMD), Houston, Texas.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L14-5010-3 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:King (1) mentions that he is “bemused” by what he calls a new career field in renaming traditional models of health care. He believes that the concepts of a medical home, patient-centered care, evidence-based medicine, and accountable care organization are merely the renaming of the multispecialty group practice, patient-directed care, decision making based on evidence, and the HMO and notes that care has always been patient-centered.That King finds these concepts bewildering is emblematic of the problem of medicine in this country. Substantially more money is spent per capita on health care in the United States than ...Reference1. King JH. Recycling. Ann Intern Med. 2014;160:68. [PMID: 24395465] LinkGoogle Scholar Author, Article, and Disclosure InformationAuthors: Richard Blakely, MDAffiliations: From Memorial Hermann Physician Network (MHMD), Houston, Texas.Disclosures: None. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L14-0112. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoRecycling James H. King Recycling James H. King Recycling Edward Volpintesta Recycling James H. King Recycling James H. King Recycling Edward Volpintesta Metrics 20 May 2014Volume 160, Issue 10Page: 738KeywordsAccountable care organizationsDecision makingDisclosureEvidence based medicineExerciseHealth careHealth care providersHealth maintenance organizations ePublished: 20 May 2014 Issue Published: 20 May 2014 Copyright & PermissionsCopyright © 2014 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Effects of Protein Deficiency on the Pregnant Woman and Fetus and on the Infant and Child
Authors: Harold C. Stuart
Journal: New England Journal of Medicine (1947)

Protein During Infancy and Childhood Requirements The primary function of protein in the diet is to provide the amino acids that are essential for the synthesis of tissue proteins characteristic of the species. In normal adults, new tissues are required only for replacement or maintenance. Disease and trauma may cause a rapid loss of nitrogen and greatly increase the need for protein at any age. In infants and children three additional factors must be considered. The young person differs from the adult in that he is immature, he is small, and he is growing.For the most part, infants and . . .
Entero-Vioform
Authors: Olof Ringertz
Journal: JAMA (1972)

<h3>To the Editor.—</h3> In a study carried out among Swedish tourists from 1963 to 1966 it was found that the Entero-Vioform oxyquinoline was not only ineffective in preventing<i>Salmonella</i>infections, but did, in fact, increase the risk of contracting such infections.<sup>1</sup>In another investigation carried out in vitro it was found that the minimum inhibitory concentration of iodochloroxyquinoline and dibromoxyquinoline was higher for salmonella strains than for most other aerobic bacteria usually found in the intestine. In mice given a prophylactic treatment with oxyquinolines, and later a challenge dose of<i>Salmonella</i>, the death rate was approximately twice as high as in untreated controls.<sup>2</sup> These findings, in addition to the reports concerning subacute myelooptic neuropathy (SMON) have caused the health authorities in Sweden to reduce the use of oxyquinoline derivatives in Sweden. From June 1, 1972, such preparations are available with prescription only and recommended only for treatment of
Barrett Esophagus
Authors: N. Mullai, Kulumani M. Sivarajan, Gail Shiomoto
Journal: Annals of Internal Medicine (1991)

Letters15 May 1991Barrett EsophagusN. Mullai, MD, Kulumani M. Sivarajan, MD, Gail Shiomoto, MDN. Mullai, MDSearch for more papers by this author, Kulumani M. Sivarajan, MDSearch for more papers by this author, Gail Shiomoto, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-114-10-913_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: Sartori and colleagues (1) reported Barrett esophagus after chemotherapy with cyclophosphamide, methotrexate, and 5-fluorouracil. The hypothesis was that the drugs induced mucosal erosions and ulcerations and re-epithelialization by undifferentiated stem cells that differentiated into various cell types characteristic of Barrett esophagus.However, it was unclear why these changes were noticed only in the lower esophageal segment rather than the entire esophagus, because mucositis has no predeliction for the lower esophagus. This suggests that gastroesophageal reflux, induced either by vomiting or disturbed functioning of the lower esophageal sphincter by the chemotherapeutic drugs, is the likely culprit for the...References1. SartoriNielsenIndelliTrevisaniPazziGrandi SIMLPE. Barrett esophagus after chemotherapy with cyclophosphamide, methotrexate, and 5-fluorouracil (CMF): an iatrogenic injury? Ann Intern Med. 1991;114:210-1. LinkGoogle Scholar2. McClaveBoyceGottfried SHM. Early diagnosis of Columnar lined esophagus: A new endoscopic diagnostic criterion. Gastrointest Endosc. 1987;33:413-6. CrossrefMedlineGoogle Scholar3. AdrianHoodSkarin RAA. Mucocutaneous reactions to antineoplastic agents. CA. 1980;30:140-56. Google Scholar4. SpechlerGoyal SR. Barrett's Esophagus. N Engl J Med. 1986; 315:362-71. CrossrefMedlineGoogle Scholar5. BremnerLynchEllis CVF. Barrett Esophagus: congenital or acquired? An experimental study of esophageal mucosal regeneration in the dog. Surgery. 1970;68:209-16. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Cook County Hospital Chicago, IL 60612 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMedical complications of bulimia nervosa and their treatmentsCyclophosphamideRisk of oesophageal cancer among patients previously hospitalised with eating disorderGastroesophageal reflux disease and bulimia nervosa - a review of the literatureDRUGS USED IN CANCER CHEMOTHERAPYGLUCOCORTICOIDS AND DISEASE – MODIFYING ANTIRHEUMATIC DRUGSEsophageal cancer in a young woman with bulimia nervosa: a case reportCyclophosphamideBulimia nervosa complicated by Barrett's esophagus and esophageal cancerCytostatics and immunosuppressive drugs 15 May 1991Volume 114, Issue 10Page: 913-913KeywordsChemotherapyCyclophosphamideDrugsEsophagusGastroesophageal reflux diseaseMethotrexateStem cellsUlcersVomiting Issue Published: 15 May 1991 PDF downloadLoading ...
A Course of Lectures on Urine, Urinary Deposits, and Calculi
Authors: L. Beale
Journal: BMJ (1859)

flammation, and fever, presents a coherency which is worthy of your attention.Tlhus: Mtechanical objects injure the common tissue; and the pro- cess of repair arises.Errors in diet (lisorder the plasma; and inflammation ap- pears.Miasms ill the air affect the corpuscles of blood; and primary fever is the rcsult.Botlh the process of repair and inflanmmation, from hin- drances andl diliculties, miiay pass into chronic or protracted forms of suppuriation, ulceration, and discharges; wihereupon, if spoiled material sl-hould enter the circulation, and, by reitera- tion or quantity, tlhoroughlly debase the plasn)a, the corpuscles suiffer, aisd fever appeals; namely, reactionary, hectic, or a plasrmia fever.
Aquatic Toxicology: Past, Present, and Prospects
Authors: John B. Pritchard
Journal: Environmental Health Perspectives (1993)

Aquatic organisms have played important roles as early warning and monitoring systems for pollutant burdens in our environment. However, they have significant potential to do even more, just as they have in basic biology where preparations like the squid axon have been essential tools in establishing physiological and biochemical mechanisms. This review provides a brief summary of the history of aquatic toxicology, focusing on the nature of aquatic contaminants, the levels of contamination in our waters, and the origins of these agents. It considers the features of the aquatic environment that determine the availability of xenobiotics to aquatic life and the fate of foreign chemicals within the organism. Finally, toxic effects are considered with primary emphasis on the potential of aquatic models to facilitate identification of the underlying mechanisms of toxicity.
Giving pediatric immunizations the priority they deserve
Authors: J. M. Hatem
Journal: JAMA (1993)

<h3>To the Editor.</h3> —Readers ofTHE JOURNALmay be interested in the development of the "Standards for Pediatric Immunization Practices" as announced by President Bush on May 11, 1992, and published April 14, 1993.<sup>1</sup> The National Vaccine Advisory Committee, composed of national and state public health officials, academicians, and consumers, approved similar recommendations in late April 1992 (these are unpublished). The Immunization Practices Advisory Committee of the Centers for Disease Control and Prevention (CDC) reviewed and approved the recommendations after formal adoption by the US Public Health Service. These points might be insignificant except for two factors. Nineteen standards were approved by the National Vaccine Advisory Committee, but only 18 appeared 2 weeks later when signed by the President. The eliminated standard read as follows: "Providers obtain permission to vaccinate a child from a parent, legal guardian, or an adult knowledgeable about the child's medical history and responsible for
SOCIETY NEWS.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dating gallstones
Authors: David F. Ransohoff
Journal: Hepatology (1987)

We investigated the natural history of cholelithiasis in 59 samples of stones from the gallbladder or common bile duct in 15 patients, using as a tracer for the timing of stone formation the 14 C released into the environment during nuclear weapons testing. The ages of the stones were correlated with the dates of onset of symptoms and with other clinical data. None of 11 symptomatic patients had symptoms or complications until at least two years (mean ± SD, 8.0 ± 5.1 years) after stone formation began. There was a lag time of 11.7 ± 4.6 years between initial stone formation and cholecystectomy. The growth rates of stones from 11 symptomatic patients and 4 asymptomatic patients were similar (2.6 ± 1.4 and 2.6 ± 1.1 mm per year). Studies of two stones retrieved from the common bile duct showed that one had the same age as a cholecystic stone; the other, removed two years after cholecystectomy, apparently grew in the common bile duct. The long latency period between the formation of gallstones and the onset of symptoms indicates that interruption of the natural progression of gallstone disease is potentially possible with medical therapy.
Book Review Emergency Medicine: An approach to clinical problem-solving Edited by Glenn C. Hamilton, Arthur B. Sanders, Gary R. Strange, and Alexander T. Trott. 1172 pp., illustrated. Philadelphia, W.B. Saunders, 1991. $95. ISBN 0–7216–4487–2 . Current Practice of Emergency Medicine Second edition. Edited by Michael Callaham. 1381 pp., illustrated. Philadelphia, B.C. Decker, 1991. $129. ISBN 1–55664–171–0 . (Distributed in the U.S. by Mosby-Year Book, St. Louis.)
Authors: Malcolm A. Creighton, Michael S. Erdos, John J. Kelly
Journal: New England Journal of Medicine (1992)
Attributes of lifelong competence in medical practice
Authors: O. L. Peterson
Journal: JAMA (1966)

Consideration of the characteristics associated with lifelong competence raises an ancient dispute about the relative influences of nature and nurture—of inheritance and environment. The process of selecting students for admission to medical school is concerned with nature. The medical curriculum and hospital training programs represent an extreme form of nurture or environment influence. What do we know about the relative contribution of these two factors to competence? Although the production of competent physicians is a major goal of the medical educational process, surprisingly few attempts have been made to determine how well this goal is achieved. The large volume of research on selection of medical students almost suggests that picking students who can complete the four-year curriculum is a goal in itself. The medical students are accessible and easily studied whereas the competence of the physicians —the medical-school output—is difficult or occasionally impossible to measure. We do, however, have a
Mary
Authors: KEITH ABLOW
Journal: Annals of Internal Medicine (1984)

Ad Libitum1 November 1984MaryKEITH ABLOWKEITH ABLOWSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-101-5-715_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe subtle sparkle in her light-blue eyes was disturbing. A sparkle on a dull background of disheveled hair and bruised arms. It refused to retreat behind the smell of alcohol that reached me as she spoke. It stubbornly remained when she told of nights alone in condemned buildings and days spent drinking gin on city buses. Alcoholics, down-and-outers, weren't supposed to have eyes that sparkled. Mary's did. I read them not with hope for her future, but with deep regret for her past.Mary told me that I couldn't understand. She laughed at my argyle sweater. She knew more about... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Baltimore, Maryland PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited by1,3-Dioxoles and 1,3-OxathiolesVolume 3 References 1 November 1984Volume 101, Issue 5Page: 715-715KeywordsAlcoholicsAlcoholsEmotionsForecastingSmell ePublished: 1 December 2008 Issue Published: 1 November 1984 PDF downloadLoading ...
Correction
Journal: Journal of Clinical Investigation (1995)

To eliminate possible ambiguity, the authors have requested that two sentences be revised.The first sentence of the paragraph beginning on page 886 should read as follows:The relationship between the bone marrow-derived human osteoprogenitor cells reported herein and past reports on bone formation derived from the colony-forming unit fibroblast (CFU-f) remains unclear.and the second full sentence on page 887 should read as follows:However, the lack of phenotypically specific fibroblast markers and a clear means to purify bone-forming CFU-f precludes analysis of their relationship to the human bone marrow osteoprogenitor cells described in the present report.
IN THE TIME OF HENRY JACOB BIGELOW
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Compartmental Syndromes
Authors: Frederick A. Matsen
Journal: New England Journal of Medicine (1979)

The compartmental syndrome is a condition in which increased pressure within an anatomic space compromises the circulation and function of the contents.1 The two prerequisites for this syndrome are an envelope of limited compliance (such as fascia, skin, plaster cast or dressings) and a cause for the increased volume within the envelope (such as bleeding or increased net capillary filtration). The combination of these prerequisites produces increased tissue pressure.The following mechanism appears to provide the most plausible explanation for the compromise in tissue-blood flow that results from increased tissue pressure.2 Veins are collapsible tubes; thus, the pressure in patent . . .
Correction to Lancet Glob Health 2019; 7: e1644–74
Journal: The Lancet Global Health (2020)

In this Article, in the final paragraph of the results the cost per newly identified positive case in the HIV self-testing group and the cost per person initiated on antiretroviral therapy in the standard providerinitiated training group, and data in the bottom two rows of table 5 have been corrected.These corrections have been made as of Jan 23, 2020.
GRANULOCYTOPENIA
Authors: Pauline Zinninger
Journal: JAMA (1934)

<h3>To the Editor:—</h3> I should like to take this opportunity to make an addition to the report of two cases of granulocytopenia, published inThe Journal, February 17. After the death of these patients it was discovered that they had used an undedetermined, but quite large quantity, of amytal compound, over a fairly long period of time. In the light of recent investigations this fact has seemed to be of possible significance, both in helping to confirm the diagnosis and as an additional link in the chain of evidence against the barbiturates, or amidopyrine, or both, as etiologic agents in this disease.
Prolonged spontaneous pneumomediastinum in adult dermatomyositis.
Authors: E Carmody, J McNicholl, G Chadwick, B Bresnihan, M X Fitzgerald
Journal: Annals of the Rheumatic Diseases (1987)

Prolonged spontaneous pneumomediastinum in adult dermatomyositis SIR, We read with great interest Dr Bradley's first reported case of pneumomediastinum in an adult with derma- tomyositis.'We describe here a similar event, where spontaneous pneumomediastinum occurred in a patient with dermatomyositis and persisted for five months.In January 1986 a 20 year old man was admitted to hospital for assessment of recent generalised muscle, weakness.Examination showed a classic periorbital helio- trope rash, violet oedematous skin lesions over the metacarpophalangeal joints, and numerous vasculitic lesions on the fingers.Proximal muscle weakness was noted and the serum creatine phosphokinase (CPK) was raised at 635 IU/I (normal 0-186 IU/l).Treatment
Isolated Hypoplasia of Spinous Process Cause of Back Pain
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal