tbuckley/cabot-search huggingface dataset:
Use of surveillance for invasive pneumococcal disease to estimate the size of the immunosuppressed HIV-infected population
Authors: A. Schuchat
Journal: JAMA (1991)

We used population-based surveillance in New Jersey in 1986 to quantify the risk of invasive pneumococcal disease in persons with the acquired immunodeficiency syndrome (AIDS) and in those who went on to develop AIDS. Using pneumococcal surveillance, we also devised a method to estimate the size of the immunosuppressed population infected with the human immunodeficiency virus (HIV), the so-called pre-AIDS population. From rates of pneumococcal disease that occurred in areas with a low incidence of AIDS, we calculated the number of patients expected to contract pneumococcal disease in areas with a high incidence of AIDS. There were 59 more cases of pneumococcal disease observed than expected; 14 of these patients had AIDS by the time of pneumococcal infection. We attributed the remaining 45 cases to the increased risk of pneumococcal infection in pre-AIDS. The pre-AIDS pneumococcal cases and the attack rate of pneumococcal disease in pre-AIDS were used to estimate the size of the 1986 pre-AIDS New Jersey population as 8823 pre-AIDS cases (95% confidence interval, 7377 to 10 714) or 0.37% of the adult New Jersey population. Surveillance for marker diseases may provide a simple, independent method of estimating the pre-AIDS population. (<i>JAMA</i>. 1991;265:3275-3279)
Containers for prescription drugs
Authors: J. C. Wilkie
Journal: JAMA (1979)

<h3>To the Editor.—</h3> Reference is made to the COMMENTARY of Sherman and associates (241:1001, 1979) concerning the problems experienced by elderly patients receiving prescriptions in child-resistant containers. The authors state that the patients and physicians do not apparently know about their options and the pharmacists fail to offer their patients the opportunity to have a nonchild-resistant prescription container. Section 4(b) of the Poison Prevention Packaging Act of 1970 is specific relative to the packaging of prescription drugs in conventional (noncomplying) packages by pharmacists. That section of the Act states: In the case of a household substance which is subject to such a standard and which is dispensed pursuant to an order of a physician, dentist, or other licensed medical practitioner authorized to prescribe, such substance may be dispensed in noncomplying packages only when directed in such order or when requested by the purchaser. I agree with the comments that there
Selective service and military medical manpower
Authors: J. C. Cain
Journal: JAMA (1968)

Much has been written about the developing shortage of medical manpower. The demand for medical services is greater than the amount physicians under the present system are able to furnish. Obviously, we must increase the output of our existing medical schools, develop new medical schools, and use the physician's time more efficiently and effectively. We have few physicians less than 35 years of age who have not served in the Armed Forces. It is now necessary for us to interrupt residency programs in the second, third, and fourth years, take men from large private practices with a large segment of the community dependent upon them, and interrupt teaching and research programs by taking instructors and assistant professors. Physicians now being selected would have been considered essential to the community welfare three years ago. The need for physicians is obvious; means for obtaining them is complicated. <h3>Classification and Deferment.—</h3> When an
Iron in Enriched Wheat Bread
Authors: C. Jelleff Carr
Journal: JAMA (1972)

<h3>To the Editor.—</h3> The AMA Council on Foods and Nutrition statement in the May 8th issue made reference to two studies: (1) an in-depth review of the state-ofthe-art concerning iron-storage phenomena in man, and (2) the feasibility of clinical research which would definitely answer the question as to whether increases in iron enrichment of cereal-based foods, of the order of magnitude exemplified by the proposal under discussion, would in fact increase either the prevalence or the severity of pathological iron-storage phenomena. This is being conducted by the Life Sciences Research Office, Federation of American Societies for Experimental Biology (LSRO/FASEB) for the Food and Drug Administration. We think it would be helpful to clarify several statements (p 858) about these LSRO/FASEB studies. The study entitled,<i>A Review of the Significance of Dietary Iron on Iron Storage Phenomena</i>, (ref 18) is not yet completed. The report is in the final stages of
Children of war: the real casualties of the Afghan conflict
Journal: BMJ (2002)

home."In this category, incidents described in general terms such as "collapse" fell from 35% to 20%, whereas those attributed more specifically to cardiac problems rose from 22% to 31% and those attributed to respiratory problems from 12% to 21% (see table C on bmj.com).We thank members of Wiltshire Ambulance Services Trust who provided data, tea, and moral support during long days of searching for records.
Leads from the MMWR. Years of life lost from cardiovascular disease
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Manganese-Induced Hypoglycemia
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Massachusetts Medical Society
Authors: Heinrich G. Brugsch
Journal: New England Journal of Medicine (1960)

TOXIC HAZARDS*The Castor Bean†Stevedores at an American port recently refused to unload a shipment of castor-bean pomace (or "cakes") because of the health hazards involved. This incident served to call to the attention of the general public late medical reports of allergic manifestations in persons exposed to castor-bean dust.1 , 2 The result, therefore, has been wider recognition of the toxic properties of the plant unpleasantly known as the source of castor oil. The plant Ricinus communis is a member of the euphorbiacae family. Although native to India3 it is now cultivated in many varieties throughout the world. Reports on . . .
Reduced Hospitalizations for Acute Myocardial Infarction After Implementation of a Smoke-Free Ordinance—City of Pueblo, Colorado, 2002-2006
Journal: JAMA (2009)

Exposure to secondhand smoke (SHS) has immediate adverse cardiovascular effects, and prolonged exposure can cause coronary heart disease. Nine studies have reported that laws making indoor workplaces and public places smoke-free were associated with rapid, sizeable reductions in hospitalizations for acute myocardial infarction (AMI). However, most studies examined hospitalizations for 1 year or less after laws were implemented; thus, whether the observed effect was sustained over time was unknown. The Pueblo Heart Study examined the impact of a municipal smoke-free ordinance in the city of Pueblo, Colorado, that took effect on July 1, 2003. The rate of AMI hospitalizations for city residents decreased 27%, from 257 per 100,000 person-years during the 18 months before the ordinance's implementation to 187 during the 18 months after it (the Phase I post-implementation period). This report extends that analysis for an additional 18 months through June 30, 2006 (the Phase II post-implementation period). The rate of AMI hospitalizations among city residents continued to decrease to 152 per 100,000 person-years, a decline of 19% and 41% from the Phase I post-implementation and pre-implementation period, respectively. No significant changes were observed in two comparison areas. These findings suggest that smoke-free policies can result in reductions in AMI hospitalizations that are sustained over a 3-year period and that these policies are important in preventing morbidity and mortality associated with heart disease. This effect likely is mediated through reduced SHS exposure among nonsmokers and reduced smoking, with the former making the larger contribution.
Happiness*
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE PUBLIC SERVICE.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Stents covered by autologous venous grafts: Beneficial effect in patients with acute coronary syndromes Konstantinos Toutouzas, Christodoulos Stefanadis, Eleftherios Tsiamis, Ioannis Kallikazaros, Costas Stratos, Manolis Vavuranakis, Costas Tentolouris, Pavlos Toutouzas. Hippokration Hospital, Athens, Greece
Journal: Journal of the American College of Cardiology (2001)
Mobile solution for clinical research documentation.
Authors: Lindsay Philip, Jasmine Grant, Calven Eggert, Aaron Di Nardo, Susanna Sellmann, Heather Cole, Marcia Flynn-Post, Leslie Williams-Brennan, Pamela Degendorfer
Journal: Journal of Clinical Oncology (2014)

e17613 Background: As trial complexity increases, there is a growing need to facilitate rapid communication of trial data among members of the research and clinical care teams. Timeliness of investigator review and high quality data are critical to clinical trial documentation. Princess Margaret developed an electronic application that meets these needs, is integrated into a patient’s medical chart, and is accessible at the point of care on a mobile device. Methods: Focus groups were held with research staff to evaluate application and device needs. Device needs were usability, compatibility with the electronic patient record (EPR), and encryption ability, which were considered and a device was selected. Standard templates were developed for the informed consent process, clinical notes, vital signs, baseline symptoms, adverse events, and concomitant medications. Electronic source (eSource) was linked to an existing CTMS, the Clinical Research Record. eSource is accessible via the EPR, allows for electronic review and sign off by investigators, and allows data capture directly into the EPR from a mobile device. Results: A 4 month pilot was completed in December 2013 with 10 clinical research nurse coordinators (CRNCs) from 3 different treatment areas, enrolling 40 patients. The project continues to roll out and will be completely integrated by August 2014. CRNCs enter information at the point of care that is easily shared amongst research and clinical care teams; important safety information is available to all staff; investigators can sign off electronically; and data has an audit trail. Conclusions: Enhancements were made within the system during the pilot to facilitate workflow as issues were identified. The system provides solutions for delayed documentation, the transfer of paper charts between team members, and investigator sign-off. This has allowed for tracking of metrics including the timeliness of documentation, review, and sign off; quality improvements to documentation can be measured through internal quality assurance reviews; and opportunities for future enhancements have been created including improving trial management, reporting of trial outcomes data, and a complete electronic integration of all paper research documentation.
Abstract 2641: Inhibition of Bcr-Abl in human leukemic cells with a coiled coil protein delivered by a leukemia-specific cell penetrating peptide
Authors: Benjamin J. Bruno, Carol S. Lim
Journal: Cancer Research (2015)

Abstract The oncoprotein Bcr-Abl is the cause of chronic myeloid leukemia (CML). Current CML therapies target the tyrosine kinase domain of Bcr-Abl, but due to their non-curative nature, resistance to these drugs is common. Therefore, new treatments are needed for those patients refractive to available therapies. Bcr-Abl homo-oligomerization via its N-terminal coiled coil (CC) domain is required for tyrosine kinase activity. Our previous work has shown that it is possible to inhibit Bcr-Abl activity by targeting the CC domain with a altered version of the CC domain, known as CCmut3, delivered as a plasmid. In this study, CCmut3 is delivered to cells as a protein by utilizing a leukemia-specific cell-penetrating peptide (CPP). Here, recombinant CPP-CCmut3 was expressed, purified, and tested for its anti-oncogenic activity. CPP-CCmut3 was able to enter two leukemic cell lines (K562 and Ba/F3-P210) and inhibit Bcr-Abl activity as shown by induction of necrosis/apoptosis via 7-AAD/Annexin V staining, reduction of oncogenic potential in colony forming assays, reduction of cell proliferation, and inhibition of Bcr-Abl phosphorylation (kinase activity). Further, CPP-CCmut3 did not enter non-leukemic cell lines (HEK293 and MCF-7). While CPP-CCmut3 was able to enter the parental, non-leukemic Bcr-Abl- Ba/F3 pro-B cell line, it revealed no signs of activity in the assays performed, as expected. These results indicate the feasibility of using CPP-CCmut3 as a therapeutic against CML. Citation Format: Benjamin J. Bruno, Carol S. Lim. Inhibition of Bcr-Abl in human leukemic cells with a coiled coil protein delivered by a leukemia-specific cell penetrating peptide. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 2641. doi:10.1158/1538-7445.AM2015-2641
CERTAIN PROBLEMS CONNECTED WITH VOLUNTARY DISPENSARIES
Authors: M. C. P.
Journal: Annals of Internal Medicine (1940)

Editorial1 February 1940CERTAIN PROBLEMS CONNECTED WITH VOLUNTARY DISPENSARIESM. C. P.M. C. P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-13-8-1509 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptVoluntary dispensaries have greatly increased in size and complexity in our larger cities in the last decade and constitute a very important factor in the medical care of urban communities. In spite of this fact, dispensaries have not received their proportionate share of attention from those interested in broad programs for public health. Yet all physicians and welfare workers realize that the unusual load placed upon dispensaries during recent years has rendered it urgent to find some solution for a number of old and fundamental problems connected with these institutions.A first problem arises from the tendency of the dispensary... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1940Volume 13, Issue 8Page: 1509-1512KeywordsPrevention, policy, and public health ePublished: 1 December 2008 Issue Published: 1 February 1940 PDF downloadLoading ...
Chemistry and Biology of Spin-Trapping Radicals Associated with Halocarbon Metabolism in Vitro and in Vivo
Authors: Edward G. Janzen, Henry J. Stronks, Coit M. Dubose, J. Lee Poyer, Paul B. McCay
Journal: Environmental Health Perspectives (1985)

The spin-trapping method is introduced and discussed. Some chemistry of nitroxides and nitrones is reviewed. Pattern recognition of ESR spectra of nitroxides is outlined. Factors controlling the magnitude of hyperfine splitting constants are mentioned. Methods of assigning spin adducts are listed. Review articles in the literature are referenced. Results in the electrochemical reduction of halocarbons are presented and some parallels with superoxide chemistry shown. Various speculative reactions are given. The in vitro and in vivo experiments where halocarbon radicals have been detected by spin trapping are reviewed and some new results reported. A comparison for different animals is added.
A randomized trial of propranolol in patients with acute myocardial infarction. I. Mortality results
Journal: JAMA (1982)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
What's new this month in BMJ Journals
Authors: Harvey Marcovitch
Journal: BMJ (2005)

An open pilot study in nine patients with chronic plantar fasciitis suggests that botulinum toxin A may prove to be a useful treatment. The patients, whose symptoms had lasted 2-36 (mean 14) months, were given 200 units of the preparation, formulated as Dysport. Pain at rest had diminished substantially at two week follow-up, with the improvement being maintained at one year. No adverse event was encountered. The authors, from Berlin, now intend to conduct a randomised controlled trial. Ann Rheum Dis 2005;64: 1659-61