tbuckley/cabot-search huggingface dataset:
Introduction
Authors: E. Christophers, D. Rigel
Journal: British Journal of Dermatology (2003)

The development of new remedies always offers a number of exciting opportunities, not only for the patients in that their sufferings and unwanted conditions can be improved, but also for the physicians. Indeed many newly discovered drugs are able to provide a better means of understanding disease, because insight into the way such compounds work in a target organ often opens the door for viewing new, previously hidden pathways in the development of pathology. This supplement contains the proceedings of a symposium, which concentrated on present day knowledge of a new compound recently introduced to clinical dermatology, imiquimod. It presented as a most remarkable event for various reasons. Firstly, medical disciplines for which mutual interest is normally limited joined for discussion, including virologists, immunologists, dermatologists, oncologists, epidemiologists and histopathologists. Secondly, as reflected by the papers published in this supplement the other remarkable event was that this new drug demonstrated therapeutic efficacy in a number of disorders of the skin, which are seemingly unrelated. For example, Ulrich Hengge and Marco Cusini discuss the efficacy of imiquimod 5% cream for the treatment of human papillomavirus‐induced infections; Stephen Shumack highlights its' efficacy for the treatment of actinic keratosis; and Eggert Stockfleth and colleagues examine its' effectiveness for the treatment of superficial basal cell carcinoma. Interestingly in this supplement, imiquimod is also examined as a treatment option for keloids, lentigo maligna, Bowenoid papulosis, and porokeratosis Mibelli of stuccokeratosis. How can we understand therapeutic efficacy and safety in such a variety of human skin disorders?
Pediatric Critical Care
Authors: Alan I. Fields
Journal: JAMA (1992)

This text attempts to define pediatric critical care medicine, both the scientific foundations and actual clinical applications. It strives to delineate the field from adult intensive care as a discrete entity. The 166 authors of the book's 113 chapters have achieved this well. The book begins with the whole patient: reports of typical pediatric intensive care unit (PICU) cases and background data used together embody the vast scope of the field. For instance, presented along with the case of a victim of near-drowning is the information that in some states it is the leading cause of death in children younger than 5 years. The discipline of pediatric critical care medicine is well described in the next section. In particular, the chapter "Invasive Measurements in the PICU" is one of the most extensive in print, covering both the basic science and the practical applications. There is also a wonderful chapter on
Abstract 3334: Predictive therapeutic value of NGS with liquid biopsy in metastatic NSCLC
Authors: Silverio Tomao, Monica Verrico, Luigi Rossi, Iacobelli Stefano
Journal: Cancer Research (2019)

Abstract Analysis of circulating tumor cells ( CTCs) and circulating cell-free DNA (cfDNA), detected in peripheral blood of patients, is an extraordinary novel strategy to identify and study NSCLC patients, in order to obtain prognostic and predictive molecular informations with a simple, non invasive and sensitive method. Liquid biopsy therefore offers a new source of cancer cells and cancer-derived materials in order to test more personalized treatment. With two PCR-based next generation sequencing (NGS) approaches we evaluated 45 patients with not squamous NSCLC ; in eighteen pts ( 40 % ) almost one genomic mutation was detected among 56 different genes analyzed with NGS. Median age of patients was 69 years ( 55-78) and 14 (73%) were males. Altogether, 11 genes were mutated with a panel of 56 genes analyzed (19,6% ) . The most frequent mutations occurred in KRAS, TP53, MET,KDR, KIT, SMAD4 and MET genes. Several patients expressed many mutations and the most frequent detected concerned gen c-Kit ( 22%). Other mutations concerned the following genes : TP53 ( 16 % ), MET/KDR. / SMAD4/KRas ( 44%). Other genomic alterations concerned the following genes: JACK3 (5%); APC(5%); ERBB4(5%); CTNNB! (5%); EGFR (5%). Altogheter the response to therapy was higher among patients with mutation of Smad 4 gene and lower in patients with mutations of KIT gene. All side effects occurred with target therapy was categorized according to the Common Terminology Criteria for Adverse Events, 4.0 version. An increase of gastroenteric (G3/G4) and hematologic toxicity (G3/G4) was observed in patients with Kit mutations. In our study this correlation was observed mainly during treatment with Tyrosine Kinase Inhibitors (TKIs ).Evaluating Progression Free Survival (PFS) in all the patients recruited in the study, a median PFS of 12.5, 11.5, 4 and 9 months was observed respectively in patients with mutations of KIT, SMAD4, TP53 and MET. In this study, all the genetic alterations analyzed and highlighted were related to the response to chemotherapeutic treatments and possible tyrosine kinase inhibitory treatments in terms of PFS and toxicity. Note: This abstract was not presented at the meeting. Citation Format: Silverio Tomao, Monica Verrico, Luigi Rossi, Iacobelli Stefano. Predictive therapeutic value of NGS with liquid biopsy in metastatic NSCLC [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3334.
3. Prevention or Delay of Type 2 Diabetes:<i>Standards of Medical Care in Diabetes—2021</i>
Journal: Diabetes Care (2020)

The American Diabetes Association (ADA) "Standards of Medical Care in Diabetes" includes the ADA's current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA Professional Practice Committee, a multidisciplinary expert committee (https://doi.org/10.2337/dc21-SPPC), are responsible for updating the Standards of Care annually, or more frequently as warranted. For a detailed description of ADA standards, statements, and reports, as well as the evidence-grading system for ADA's clinical practice recommendations, please refer to the Standards of Care Introduction (https://doi.org/10.2337/dc21-SINT). Readers who wish to comment on the Standards of Care are invited to do so at professional.diabetes.org/SOC.
AMA SPECIALTY JOURNAL ABSTRACTS
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The MAHI appropriateness criteria: A new method for quantifying the indications for PCI John A. Spertus, Radhika Tripuraneni, Warren B. Johnson, Philip G. Jones, Steven P. Marso, James L. Vacek, Brent D. Bliven, Ben D. McCallister. Mid America Heart Institute, Kansas City, MO
Journal: Journal of the American College of Cardiology (2001)
Incidence and patterns of secondary malignancies in patients with neuroendocrine neoplasms: A SEER database analysis.
Authors: Meena Sadaps, Neal Mehta, Hong Li, Bassam N. Estfan
Journal: Journal of Clinical Oncology (2021)

e16208 Background: Neuroendocrine neoplasms (NENs) are a group of biologically and clinically heterogenous malignancies of different anatomic sites, the majority of which lie within the gastrointestinal (GI) tract. Prior literature has reported on the association between NENs and other primary malignancies (OPM), but these studies are limited by small sample sizes. We aim to further analyze the association of NENs and OPM on a larger scale using a population-based cancer registry. Methods: Primary malignancies with NEN features were identified from the Surveillance Epidemiology and Ends Results registry between 1975-2017. The histology/behavior of NEN included carcinoid tumor, neuroendocrine carcinoma (NEC), pancreatic endocrine tumor, atypical carcinoid tumor, and other (insulinoma, glucagonoma, gastrinoma, VIPoma, somatostatinoma and enterochromaffin cell carcinoid). First NEN observation from each patient was examined. Patients with NEN were grouped into 3 categories: NEN only, NEN first followed by OPM, and non-NEN first followed by NEN based on sequence number of primary cancer. Secondary malignancy sites were analyzed. Distribution of NEN between GI and non-GI sites was described. Demographics were compared by NEN sequence groups and between GI and non-GI sites. Results: 45,896 patients with NEN were analyzed (77.9% Caucasian, 47.0% male, median age 62.0 yrs). 65.7% of NENs were observed in GI sites. Within the GI tract, 31.3% were small intestine, 25.1% rectum, 16.6% pancreatobiliary, and &lt; 11% in other GI locations. Age at NEN diagnosis was younger in those with GI NENs (median 60.0 vs 65.0, p &lt; 0.001). 71.2% of patients had NEN only, 10.4% had NEN first followed by OPM, and 18.4% had a non-NEN primary followed by NEN. Mean age was 58.9 for NEN primary only, 61.0 for NEN primary first and 68.3 for non-NEN primary first (p &lt; 0.0001). More Caucasian patients had non-NEN primary first (82.3%) compared to NEN primary only (76.9%) and NEN primary first (75.5%). There were no gender differences amongst the three groups. Carcinoid tumor histology was more prevalent in NEN primary first (78.6%) compared to NEN primary only (67.3%) and non-NEN primary first (66.6%), while NEC histology was more prevalent in NEN only (27.4%) and non-NEN first (29.3%) compared to NEN first. Among patients with NEN first followed by a second primary malignancy (SPM), 23.6% of females had a secondary breast malignancy and 28.9% of males had a secondary prostate malignancy. Conclusions: 28.8% of patients with NENs were found to have OPM, either preceding or following their NEN diagnosis. Of those with a SPM following NEN, breast and prostate were the most common sites for women and men, respectively. It is imperative that patients with NEN undergo age-appropriate cancer screening to help identify any concurrent malignancies. Further research is warranted to identify the timeframe in which they occur in relation to the NEN.
Prescribing exercise in general practice
Authors: S. Iliffe, S. S. Tai, M. Gould, M. Thorogood, M. Hilsdon
Journal: BMJ (1995)

Salt tolerance is strongly related to potassium (K+) retention in plant tissues under salt stress conditions. However, it is unclear for different Echinacea species. So, mechanistic basis of four Echinacea species (i.e. Echinacea purpurea, Echinacea angustifolia, Echinacea pallida, and Echinacea sanguinea) to salinity stress tolerance, and K+ retention were assessed in the present study. Non-invasive microelectrode ion flux measuring, DHAR and MDHAR activities, and pharmacological measurements were performed based on the standard methods. Ion flux measurements revealed higher K+ efflux in E. pallida and E. sanguinea species compared to the E. purpurea and E. angustifolia species in the elongation zone. Higher salinity-induced H+ efflux was found in the elongation zone than mature zone. However, E. angustifolia and E. purpurea had more Ca2+ influx compared to E. pallida and E. sanguinea species. Net K+ efflux decreased (&gt; 90%) in the presence of TEA and GdCl3. Increasing Ca2+ uptake and K+ loss in four Echinacea species roots were found in the presence of 0.3 mM Cu/Ascorbate (Cu/Asc). The significant role of H+-ATPase in H+ efflux was demonstrated by Sodium orthovanadate. Ultimately, the physiological properties of Echinacea species have a critical role in salinity-resistant/sensitive differences. Future scientific understanding of Echinacea species physiognomies may be necessary for a better understanding of the plant behavior to salinity stress.
BOOK REVIEWS
Authors: D. GELLER
Journal: JNCI Journal of the National Cancer Institute (1990)

Journal Article BOOK REVIEWS Get access Coping With Childhood Cancer: Where Do We Go From Here? David W. Adams , Eleanor J. Deveau , eds. Ontario, Canada : Kinbridge Publications , 1989 , 297 pp. $19.95. DONNA GELLER DONNA GELLER Clinical Center Social Work Department/Pediatric Branch National Cancer Institute Bldg10, Rm. 1C-144 Bethesda, MD 20892 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 82, Issue 4, 21 February 1990, Page 315, https://doi.org/10.1093/jnci/82.4.315 Published: 21 February 1990
Standardized uptake value (SUV) by positron emission tomography/computed tomography (PET/CT) as a prognostic variable in metastatic breast cancer (MBC).
Authors: P. G. Morris, M. Fazio, K. L. Jhaveri, C. Serna-Tamayo, A. Eaton, S. Patil, G. Ulaner, J. Howard, S. M. Larson, C. Hudis, M. S. Jochelson, H. L. McArthur
Journal: Journal of Clinical Oncology (2011)

567 Background: The accurate prediction of outcome from MBC is challenging. PET/CT could be useful as it combines anatomical with functional imaging. This could enable greater individualization of treatment. However, there is substantial SUV variation by site. In this retrospective, single-institution study, we examine baseline SUV on PET/CT as a predictor of outcome from MBC. Methods: Patients (Pts) with ≥1 metastatic lesion on PET/CT performed ≤60 days of diagnosis of MBC from 01/01/2001 to 12/31/2008 were identified through institutional databases. Pts who received chemotherapy < 30 days prior to PET/CT were excluded. Electronic medical record reports were reviewed and maximum SUV (SUV-MAX) by site for lesions in bone, liver, lung, and lymph node (LN) was recorded. In a secondary analysis, PET/CT scans were reviewed and SUV-MAX recalculated. Relationships between SUV-MAX tertiles and OS were assessed using Cox regression by site. Results: We identified 285 pts, median age 57 yrs (range 27-90) who had PET/CT at median of 2.3 yrs (range 0-41) from primary BC (67% ER+ and 21% HER2+). The median time between PET/CT and MBC diagnosis was -9 days (range -58 to 59). At median follow-up of 53 mths, 163 pts have died and median OS is 41 mths (95%CI 34-48). The SUV-MAX by site was; bone (N=159) median 7.0 (range 2.1 - 29.6); liver (N=55) median 8.2 (range 2.9 - 51.2); lung (N=89) median 4.7 (range 1.1 - 24.0); LN (N=180) median 6.9 (range 1.2 - 34.0). On univariate analysis, higher SUV in bone was associated with shorter survival (p<0.001); table. This was maintained in multivariate analyses after adjusting for known prognostic variables (p=0.02). A similar trend for shorter survival for higher SUV was noted in liver (p=0.07). However, no relationship between SUV and OS was noted in lung (p =0.34) and LN (p=0.6). Conclusions: This large retrospective study of pts with chemotherapy-naïve MBC suggests that SUV-MAX in bone strongly correlates with prognosis. SUV in bone: Univariate analysis for OS. Variable N (%) N P value HR Max SUV Tertiles 159 <.001 1 54 (34%) – (ref) 2 53 (33%) – 1.42 3 52 (33%) – 2.76 ER neg 38 (24%) 159 <.001 2.55 HER2 neg 122 (80%) 152 0.56 0.86 Grade 3 103 (75%) 138 0.03 1.95
Occupational Medicine
Authors: Harriet L. Hardy
Journal: New England Journal of Medicine (1952)

Apparently Benign Pneumoconiosis The inhalation of certain dusts may produce x-ray pictures that are alarming in appearance. However, there is no reaction to such dusts and their chief hazard is mistaken diagnosis, with resultant unnecessary anxiety and poor medical advice to the worker. Hamlin117 has recently discussed the differential diagnosis between silicosis and siderosis, the benign x-ray picture caused by inhalation of iron oxide. The term benign pneumoconiosis is applied to these cases, and the physician will do well to acquaint himself with the available facts. Hamlin and Weber118 have made clinical and chest x-ray studies of 69 foundry grinders . . .
Fever—A Manifestation of Preleukemia
Authors: Blossom Zanger
Journal: JAMA (1976)

A patient had a preleukemic syndrome in which the major manifestation was a chronic relapsing fever over an 18-month period. A review of the literature shows that fever may be present in a considerable number of patients with preleukemia. (<i>JAMA</i>236:1266-1268, 1976)
From the Centers for Disease Control. Fluoridation of community water systems
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pesticides and Childhood Cancers
Authors: Julie L. Daniels, Andrew F. Olshan, David A. Savitz
Journal: Environmental Health Perspectives (1997)

To evaluate the possible association between pesticides and the risk of childhood cancers, epidemiologic studies published between 1970 and 1996 were critically reviewed. Thirty-one studies investigated whether occupational or residential exposure to pesticides by either parents or children was related to increased risk of childhood cancer. In general, the reported relative risk estimates were modest. Risk estimates appeared to be stronger when pesticide exposure was measured in more detail. Frequent occupational exposure to pesticides or home pesticide use was more strongly associated with both childhood leukemia and brain cancer than either professional exterminations or the use of garden pesticides. Occupational pesticide exposure was also associated with increased risk of Wilms' tumor, Ewing's sarcoma, and germ cell tumors. Residence on a farm, a proxy for pesticide exposure, was associated with increased risk of a number of childhood cancers. Although increased risk of some childhood cancers in association with pesticide exposure is suggested by multiple studies, methodological limitations common to many studies restrict conclusions; these include indirect exposure classification, small sample size, and potential biases in control selection. Opportunities for methodologic improvement in future studies of pesticides and childhood cancers are described.
Child Psychology for Professional Workers
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Planned Parenthood: A Practical Guide to Birth-Control Methods
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Chrysotile in Water
Authors: Sidney Speil
Journal: Environmental Health Perspectives (1974)

The problems of quantitating chrysotile in water by fiber count techniques are reviewed briefly and the use of mass quantitation is suggested as a preferable measure. Chrysotile fiber has been found in almost every sample of natural water examined, but generally transmission electron miscroscopy (TEM) is required because of the small diameters involved. The extreme extrapolation required in mathematically converting a few fibers or fiber fragments under the TEM to the fiber content of a liquid sample casts considerable doubt on the validity of numbers used to compare chrysotile contents of different liquids.
Neuropilin-2 mediates VEGF-C–induced lymphatic sprouting together with VEGFR3
Authors: Yunling Xu, Li Yuan, Judy Mak, Luc Pardanaud, Maresa Caunt, Ian Kasman, Bruno Larrivée, Raquel del Toro, Steven Suchting, Alexander Medvinsky, Jillian Silva, Jian Yang, Jean-Léon Thomas, Alexander W. Koch, Kari Alitalo, Anne Eichmann, Anil Bagri
Journal: The Journal of Experimental Medicine (2010)