tbuckley/cabot-search huggingface dataset:
PTH-029 <i>Helicobacter pylori</i>-associated hypochlorhydria in children relates to the development of iron deficiency
Authors: P R Harris, A Villagran, C Serrano, I Duarte, H J Windle, J E Crabtree
Journal: Gut (2010)

Introduction Acute H pylori infection is associated with transient hypochlorhydria of variable duration. Hypochlorhydria in H pylori -associated atrophy has a role in iron deficiency (ID) through changes in the physiology of iron absorption. The role of hypochlorhydria in H pylori -associated ID in childhood has not been investigated. The aims were to evaluate the association between H pylori -associated hypochlorhydria and ID in children. Methods A total of 123 children were prospectively enrolled in the study. Any child with peptic ulceration, or who received antacids, PPIs, H2 antagonists, and antibiotics in the previous 4 weeks was excluded. Blood was taken for complete blood count and iron profile. Gastric biopsies were taken for H. pylori determination by histology and rapid urease test. H pylori status was defined as +ve if either test was positive. Gastric juice was obtained at the beginning of the endoscopy avoiding water insufflation. Duodenal biopsies were taken for exclusion of coeliac disease (CD). Stool samples were collected for parasitology/microbiology. Of the 123 children, 2 with CD, 8 with non-specific duodenal inflammation (DI), 5 with lost blood analysis and 9 with parasitic infections (2 with DI) were excluded. Results Of the remaining 101 children 31 were H pylori +ve and 10 were hypochlorhydric (pH>4). There were no differences in demographic characteristics with regard to infection status, or gastric pH. In H pylori +ve children with pH >4 (n=6) serum iron (median (IQR): 60.2 (45–66) μg/dl) and transferrin saturation levels percentage (16.6 (15–19)) were significantly lower (p<0.01) than H pylori positive children (n=25) with pH≤4 (iron 113.2 (91–132); transferrin saturation 32.6 (24–38)). No differences in ferritin or TIBC were observed. In H pylori negative children with pH>4 (n=4) both iron (119 (101–137)), and transferrin saturation (36.4 (31–41)), were not significantly different from children with pH≤4 (n=66) (iron 98.7 (80–122); transferrin saturation 32.2 (25–40)). Conclusion Low serum iron and transferrin in childhood H pylori infection is associated with hypochlorhydria. In uninfected children, hypochlorhydria was not associated with altered serum iron parameters, indicating a combination of H pylori infection and/or inflammation and hypochlorhydria has a role in the aetiology of iron deficiency. Even though H pylori -associated hypochlorhydria may reflect a transient period during acute gastritis, it alters iron homeostasis with clinical impact in developing countries with a high H pylori prevalence. Funded by EU CONTENT Project (INCO-CT-2006-032136) and CONICYT/BM (RUE #29).
Abstract 5054: Are co-occurring structural birth defects associated with risk of acute lymphoblastic leukemia among children with Down syndrome
Authors: Jeremy M. Schraw, Tiffany M. Chambers, John P. Woodhouse, Peter H. Langlois, Mark A. Canfield, Angela E. Scheuerle, Michael E. Scheurer, Sharon E. Plon, Karen R. Rabin, Philip J. Lupo
Journal: Cancer Research (2019)

Abstract Background: Children with Down syndrome (DS) have a 15- to 20-fold increased risk of developing acute leukemia (ALL). While children with DS typically also present with multiple co-occurring major and minor structural birth defects, very little is known about whether the number and type of these co-occurring birth defects in children with DS are associated with risk of ALL. Methods: The Genetic Overlap Between Anomalies and Cancer in Kids (GOBACK) Study included linking data from population-based birth defects and cancer registries in Texas for the years 1999-2013. We performed a case-control analysis of ALL risk in participants diagnosed with DS. We evaluated the risk of ALL according to the presence of major birth defects in eight organ systems, as well as by the number of birth defects. Results: We identified 7,684 children with DS (controls) and 81 children with DS-ALL (cases) from among 5.7 million live births. There was a high burden of co-occurring birth defects in both the DS and DS-ALL groups, with 97% compared to 98% being diagnosed with at least one co-occurring birth defect (p = 0.39), respectively, and 68% compared to 71% being diagnosed with at least one major birth defect (p = 0.33). Similar to what has been reported among the general population of ALL patients, children with DS and ALL had a significantly higher mean birthweight (3088 vs 2891 g, p &amp;lt;0.001) than children with DS overall, and were born to older parents (mean maternal age 33.7 vs. 31.7 yrs, p = 0.01; mean paternal age 36.6 vs. 33.8 yrs, p = 0.02). Although there were trends towards increased prevalences of major birth defects overall and in most organ systems among the DS-ALL group, none reached statistical significance. Similarly, we identified a non-significantly greater mean number of total birth defects in the DS-ALL group (p = 0.2). Neither number of total birth defects nor number of major birth defects were associated with ALL in multivariable Cox regression models. Conclusions: In this population-based assessment, we did not find strong evidence that co-occurring structural birth defects were related to ALL risk among children with DS. However, the small numbers of children with DS-ALL make it difficult to draw definitive conclusions. Citation Format: Jeremy M. Schraw, Tiffany M. Chambers, John P. Woodhouse, Peter H. Langlois, Mark A. Canfield, Angela E. Scheuerle, Michael E. Scheurer, Sharon E. Plon, Karen R. Rabin, Philip J. Lupo. Are co-occurring structural birth defects associated with risk of acute lymphoblastic leukemia among children with Down syndrome [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 5054.
AN IMPROVED URETHRAL INSTILLATING SYRINGE
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Manuscripts Approved for JNCI, November-December 1972
Journal: JNCI Journal of the National Cancer Institute (1973)

Manuscripts Approved for JNCI, November-December 1972 Get access JNCI: Journal of the National Cancer Institute, Volume 50, Issue 1, January 1973, Pages 298–299, https://doi.org/10.1093/jnci/50.1.298 Published: 01 January 1973
Comparative Carcinogenic Potencies of Particulates from Diesel Engine Exhausts, Coke Oven Emissions, Roofing Tar Aerosols and Cigarette Smoke
Authors: Roy E. Albert
Journal: Environmental Health Perspectives (1983)

Mammalian cell mutagenesis, transformation and skin tumorigenesis assays show similar results in comparing the potencies of diesel, coke oven, roofing tar and cigarette smoke particulates. These assay results are reasonably consistent with the comparative carcinogenic potencies of coke oven and roofing tar emissions as determined by epidemiological studies. The bacterial mutagenesis assay tends to show disproportionately high potencies, particularly with diesel particulates. Results to date encourage the approach to the assessment for carcinogenic risks from diesel emissions based on the use of epidemiological data on cancer induced by coke oven emissions, roofing tar particulates and cigarette smoke with the comparative potencies of these materials determined by in vivo and in vitro bioassays.
Pink Roses
Journal: JAMA Internal Medicine (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Tracheobronchomegaly (Mounier-Kuhn syndrome)
Authors: J. L. Guest
Journal: JAMA (1977)

FEW DISEASES in the respiratory system are as poorly understood and as frustrating to treat as the syndrome first described clinically by Mounier-Kuhn in 1932, characterized by a diffuse dilation of the trachea and major bronchi. Although some patients with this condition are asymptomatic, the following case demonstrates the usual course of the disease, leading ultimately to death from uncontrolled infection and respiratory insufficiency. <h3>Report of a Case</h3> A nonsmoking 43-year-old woman was first seen in March 1974 with a clinical and roentgenographic picture of right lower lobe pneumonia. For three years she had had a chronic cough, productive of several mouthfuls of purulent sputum each day. The preceding year she had noticed progressive exertional dyspnea. She denied any previous respiratory illnesses and specifically could not recall any neonatal or childhood pneumonia or foreign body aspiration. Repeated sputum cultures yielded a<i>Proteus</i>organism. Smears and cultures were negative for acid-fast
Lung Cancer in a Nonsmoking Underground Uranium Miner
Authors: Karen B. Mulloy, David S. James, Kim Mohs, Mario Kornfeld
Journal: Environmental Health Perspectives (2001)

Working in mines is associated with acute and chronic occupational disorders. Most of the uranium mining in the United States took place in the Four Corners region of the Southwest (Arizona, Colorado, New Mexico, and Utah) and on Native American lands. Although the uranium industry collapsed in the late 1980s, the industry employed several thousand individuals who continue to be at increased risk for developing lung cancers. We present the case of a 72-year-old Navajo male who worked for 17 years as an underground uranium miner and who developed lung cancer 22 years after leaving the industry. His total occupational exposure to radon progeny was estimated at 506 working level months. The miner was a life-long nonsmoker and had no other significant occupational or environmental exposures. On the chest X-ray taken at admission into the hospital, a right lower lung zone infiltrate was detected. The patient was treated for community-acquired pneumonia and developed respiratory failure requiring mechanical ventilation. Respiratory failure worsened and the patient died 19 days after presenting. On autopsy, a 2.5 cm squamous cell carcinoma of the right lung arising from the lower lobe bronchus, a right broncho-esophageal fistula, and a right lower lung abscess were found. Malignant respiratory disease in uranium miners may be from several occupational exposures; for example, radon decay products, silica, and possibly diesel exhaust are respiratory carcinogens that were commonly encountered. In response to a growing number of affected uranium miners, the Radiation Exposure Compensation Act (RECA) was passed by the U.S. Congress in 1990 to make partial restitution to individuals harmed by radiation exposure resulting from underground uranium mining and above-ground nuclear tests in Nevada.
Action and Use of Oxygen Gas, When Administered as a Therapeutic Agent
Authors: S. B. Birch
Journal: BMJ (1868)

tery was probably external to the dura mater.But if the consciousness be only sufficient to enable the man to say a word or two after mucb rousing, or to produce a state which might be mistaken for drunkenness, then it must go for very little.Such a state, during the first hour or two, is quite compatible with severe lacerations of brain-substance.
Retraction Note: CXCR2 mediates NADPH oxidase–independent neutrophil extracellular trap formation in cystic fibrosis airway inflammation
Authors: Veronica Marcos, Zhe Zhou, Ali Önder Yildirim, Alexander Bohla, Andreas Hector, Ljubomir Vitkov, Eva-Maria Wiedenbauer, Wolf Dietrich Krautgartner, Walter Stoiber, Bernd H Belohradsky, Nikolaus Rieber, Michael Kormann, Barbara Koller, Adelbert Roscher, Dirk Roos, Matthias Griese, Oliver Eickelberg, Gerd Döring, Marcus A Mall, Dominik Hartl
Journal: Nature Medicine (2011)
A Few Facts relative to Vaccination
Journal: BMJ (1841)

skull, and rectum, are illustrated by appropriate woodcuts; and the article concludes with a very complete bibliogra- phy of cancer.We have already expressed a general opinion on the merits of this able essay.In a department of medical science which requires for its cultivation great assiduity, sound judgment, and quick apprehension, it is enlcouraging to find that a labourer has appeared, who may one day prove himself worthy to follow the steps of a Meckel, a Cruveilhier, or a Carswell.
Heparin Osteoporosis
Authors: George C. Griffith
Journal: JAMA (1965)

Studies of 117 patients on long-term sodium heparin therapy disclosed cumulative evidence of a relationship between prolonged use of large amounts of heparin and osteoporosis. No symptoms of osteoporosis developed in 107 who received 10,000 units of concentrated sodium heparin once daily or less for 1 to 15 years. Of ten treated daily with larger doses (15,000 to 30,000 units) for six months or longer, spontaneous fractures of vertebrae or ribs developed in six, and biopsies disclosed soft, bony matrix. Studies of rats on sufficient heparin therapy to triple clotting for ten days indicated that collagenolytic activity of rat-bone-cell homogenate increased two to four times, and the stability of the lysosome-like bodies in bone cells which contain collagenase appears to be decreased. If these observations are true, hyperheparin states, whether spontaneous or man-induced, may take their place in the small growing category of lysosomal diseases.
Infants and Gin Mania in 18th-century London
Authors: A. E. Rodin
Journal: JAMA (1981)

A study of Hogarth's engraving,<i>Gin Lane</i>, highlights the fact that alcoholic addiction in parents results not only in the fetal alcohol syndrome, but also in other types of infant abuse. Physical trauma, loss of parents, neglect, and malnutrition are all depicted. There is the strong implication that the causes of such infant abuse, and thus the prevention, lie largely in socioeconomic and cultural fields, rather than in that of medical scienc (<i>JAMA</i>1981;245:1237-1239)
Comparative Pathological Effects of Radiomimetic Agents and Roentgen Rays
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
GRANULOMA ANNULARE
Authors: H. RADCLIFFE-CROCKER
Journal: British Journal of Dermatology (1902)

IN 1893 I read before the American Dermatological Association, at their annual meeting at Milwaukee, a paper on " Lupus Erythematosus as an Imitator,"* and gave as an example of its sometimes imitating Lichen planus a case which subsequent experience of like cases has led me to believe belongs to a special type of disease midway between an inflammation and a neoplasm, both in its clinical and pathological features.Although some of the cases have been previously published, I repeat them here for convenience of future reference.CASE I.-PERsoNAL.-AlexanderT., aged 20, photographer, came first to University College Hospital lts an out-patient on May 25th, 1892.The disease for which he sought advice, began when he waa in good health, four years previously, on the right wrist and on the extensor aspect of the root of the thumb.The first lesions were two split-pea sized slightly raised flat nodules of a pale red colour, which were accompanied by slight itching.They increased very slightly in
Dialysis arthropathy: amyloid or iron?
Authors: N R Cary, D Sethi, E A Brown, C C Erhardt, D F Woodrow, P E Gower
Journal: BMJ (1986)

The clinical, biochemical, radiological, and pathological features in five cases of dialysis arthropathy were analysed. All patients were receiving long term haemodialysis and had had multiple blood transfusions. The arthropathy affected both large and small joints, was predominantly bilateral, and in all cases was associated with the carpal tunnel syndrome. In some instances joint pain was exacerbated during dialysis. In four cases the serum ferritin concentration was raised. Radiological examination showed a few juxta-articular cysts and erosions but most affected joints looked normal. All synovial tissue examined showed amyloid, which stained immunohistochemically for beta 2 microglobulin. Large amounts of iron were present in synovial tissue from affected joints. It is suggested that the deposits of iron, rather than amyloid, in synovial tissue may be the cause of the arthropathy. Iron may be derived locally as a result of haemarthrosis or it may be a manifestation of systemic iron overload.
What's new in the other general journals
Authors: Alison Tonks
Journal: BMJ (2006)

Preoperative radiotherapy is a standard treatment option for patients with stage T3 or T4 rectal cancers. The role of chemotherapy is less clear. A clinical trial found that additional chemotherapy based on fluorouracil had no impact on patients' survival, but it did help to prevent local recurrences whether it was given before or after surgery. Credit: N ENGL J MED Four groups of patients (total 1011) had preoperative radiotherapy plus either preoperative chemotherapy, postoperative chemotherapy, both, or neither. About 65% of them survived for five years regardless of their assigned treatment. But patients who had no chemotherapy at all were more likely to have a local recurrence (17%) than the other three groups (8.7%, 9.6%, and 7.6%, P = 0.002). Credit: LANCET The timing of the chemotherapy didn't seem to matter, except that patients who had their treatment before surgery were more likely complete it. Less than half the patients who were meant to have postoperative chemotherapy managed to complete the course specified by the protocol of the trial. Over a quarter failed to start, mostly because they had postoperative complications, disease progression, or simply said no. The authors conclude that preoperative chemotherapy with fluorouracil is probably worth considering for some patients. N Engl J Med 2006;355: 1114–23 [OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] American doctors often prescribe antibiotics for children with acute otitis media, even though there is good evidence from Europe that a “wait and see” policy can work just as well. They now have their own culturally specific evidence from a large trial set in an urban emergency department in New Haven, Connecticut. Children whose parents were given a delayed prescription to fill in if their child wasn't better (or got worse) over the next two days had similar short and medium term outcomes as children who were given antibiotics immediately. Immediate antibiotics made no difference to the children's … [1]: {openurl}?query=rft.jtitle%253DNew%2BEngland%2BJournal%2Bof%2BMedicine%26rft.stitle%253DNEJM%26rft.issn%253D0028-4793%26rft.aulast%253DBosset%26rft.auinit1%253DJ.-F.%26rft.volume%253D355%26rft.issue%253D11%26rft.spage%253D1114%26rft.epage%253D1123%26rft.atitle%253DChemotherapy%2Bwith%2BPreoperative%2BRadiotherapy%2Bin%2BRectal%2BCancer%26rft_id%253Dinfo%253Adoi%252F10.1056%252FNEJMoa060829%26rft_id%253Dinfo%253Apmid%252F16971718%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1056/NEJMoa060829&link_type=DOI [3]: /lookup/external-ref?access_num=16971718&link_type=MED&atom=%2Fbmj%2F333%2F7569%2F643.atom [4]: /lookup/external-ref?access_num=000240462800006&link_type=ISI
Hematopoietic Stem Cell Gene Therapy For Wiskott- Aldrich Syndrome
Authors: Maximilian GW Witzel, Christian J. Braun, Kaan Boztug, Anna Paruzynski, Michael H. Albert, Adrian Schwarzer, Ute Modlich, Rita Beier, Gudrun Göhring, Sonja Naundorf, Klaus Kühlcke, Martina Rose, Christopher Fraser, Liesl Mathias, Rudolf Ferrari, Miguel R. Abboud, Waleed Al-Herz, Irina Kondratenko, László Maródi, Brigitte Schlegelberger, Christopher Baum, Manfred Schmidt, Christof von Kalle, Christoph Klein
Journal: Blood (2013)