tbuckley/cabot-search huggingface dataset:
&lt;TITLE&gt;Antibiotics&lt;/TITLE&gt;
Journal: JAMA (2001)

The JAMA Patient Page is a public service of JAMA.The information and recommendations appearing on this page are appropriate in most instances, but they are not a substitute for medical diagnosis.For specific information concerning your personal medical condition, JAMA suggests that you consult your physician.This page may be reproduced noncommercially by physicians and other health care professionals to share with patients.Any other reproduction is subject to AMA approval.
Shall The Journal be Removed to Washington?
Authors: Geo. A. Zeller
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Molecular Profiling of Extramedullary and Medullary Plasmacytomas.
Authors: Anuj Mahindra, Samir B Amin, Gabriela Motyckova, Aliyah R. Sohani, Kishan Patel, Sonia Vallet, Gaurav Chetri, Adam Ackerman, Samantha Pozzi, Loredana Santo, Diana Cirstea, Christiana E. Toomey, Ephraim P. Hochberg, Paola Dal Cin, Teru Hideshima, Kenneth C. Anderson, Nikhil Munshi, Noopur Raje
Journal: Blood (2009)
לְדוֹר וָדוֹר
Authors: Howard A. Rockman
Journal: Journal of Clinical Investigation (2017)

L'dor vador, transliterated from the Hebrew above, is an ancient concept in Judaic scripture meaning "from generation to generation," which is now generally interpreted to mean that we have a responsibility to pass on teachings to future generations. It has been 5 years that I have been at the helm of the Duke-UNC Editorial Board of the Journal of Clinical Investigation and have had the privilege of publishing scientific knowledge that will be passed on to generations of future scientists. Now, with the selection of Dr. Gordon Tomaselli as the next editor in chief, I pass on the editorial duties for the JCI to him and his team at Johns Hopkins.
Abstract B25: Decoding tumor microenvironment to enhance NSCLC targeted therapy
Authors: Haichuan Hu, Lecia Sequist, Zofia Piotrowska, Hillary Mulvey, Sundus Noeen, Patricia Hare, David Kodack, Aaron Hata, Matt Niederst, Cyril Benes, Jeff Engelman
Journal: Clinical Cancer Research (2018)

Abstract This abstract is being presented as a short talk in the scientific program. A full abstract is printed in the Proffered Abstracts section (PR04) of the Conference Proceedings. Citation Format: Haichuan Hu, Lecia Sequist, Zofia Piotrowska, Hillary Mulvey, Sundus Noeen, Patricia Hare, David Kodack, Aaron Hata, Matt Niederst, Cyril Benes, Jeff Engelman. Decoding tumor microenvironment to enhance NSCLC targeted therapy [abstract]. In: Proceedings of the Fifth AACR-IASLC International Joint Conference: Lung Cancer Translational Science from the Bench to the Clinic; Jan 8-11, 2018; San Diego, CA. Philadelphia (PA): AACR; Clin Cancer Res 2018;24(17_Suppl):Abstract nr B25.
Book Review The Treatment of the Common Disorders of Digestion — A Handbook for Physicians and Students . By John L. Kantor, Ph.D., M.D., Visiting Physician in Gastrointestinal Diseases, Vanderbilt Clinic, Presbyterian Hospital; Associate in Medicine, Columbia University; Gastroenterologist and Associate Roentgenologist, Montefiore Hospital for Chronic Diseases, New York City. Second Edition. The C. V. Mosby Company, St. Louis. 300 pages. Price $6.00.
Journal: New England Journal of Medicine (1930)
LONDON
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fatal pulmonary aspiration of oral activated charcoal.
Journal: BMJ (1988)

correct, as the plasma concentration of vitamin A is closely controlled.The multi-infarct group had an -intermediate mean plasma carotene concentration and showed no significant correlation between plasma carotene and plasma vitamin A concentrations (Spearman coefficient 0 32).These findings very probably result from including patients who also have Alzheimer's disease in the multi-infarct group.5The cause of carotenaemia in Alzheimer's disease is unclear.Although there is considerable overlap with other groups, increased plasma carotene con- centrations may be useful as a diagnostic criterion for Alzheimer's disease.
Body piercing
Authors: H. Ferguson
Journal: BMJ (1999)

<h3>Background</h3> Nuclear protein 1 (Nupr1) is a major factor in the cell stress response required for <i>Kras<sup>G12D</sup></i>-driven formation of pancreatic intraepithelial neoplastic lesions (PanINs). We evaluated the relevance of Nupr1 in the development of pancreatic cancer. <h3>Methods</h3> We investigated the role of Nupr1 in pancreatic ductal adenocarcinoma (PDAC) progression beyond PanINs in <i>Pdx1-cre;LSL-Kras<sup>G12D</sup>;Ink4a/Arf<sup>fl/fl</sup></i>(<i>KIC</i>) mice. <h3>Results</h3> Even in the context of the second tumorigenic hit of <i>Ink4a/Arf</i> deletion, Nupr1 deficiency led to suppression of malignant transformation involving caspase 3 activation in premalignant cells of <i>KIC</i> pancreas. Only half of <i>Nupr1</i>-deficient;<i>KIC</i> mice achieved PDAC development, and incident cases survived longer than <i>Nupr1<sup>wt</sup>;KIC</i> mice. This was associated with the development of well-differentiated PDACs in <i>Nupr1</i>-deficient;<i>KIC</i> mice, which displayed enrichment of genes characteristic of the recently identified human classical PDAC subtype. <i>Nupr1</i>-deficient;<i>KIC</i> PDACs also shared with human classical PDACs the overexpression of the Kras-activation gene signature. In contrast, <i>Nupr1<sup>wt</sup>;KIC</i> mice developed invasive PDACs with enriched gene signature of human quasi-mesenchymal (QM) PDACs. Cells derived from <i>Nupr1-</i>deficient;<i>KIC</i> PDACs growth in an anchorage-independent manner in vitro had higher aldehyde dehydrogenase activity and overexpressed nanog, Oct-4 and Sox2 transcripts compared with <i>Nupr1<sup>wt</sup>;KIC</i> cells. Moreover, <i>Nupr1</i>-deficient and <i>Nurpr1<sup>wt</sup>;KIC</i> cells differed in their sensitivity to the nucleoside analogues Ly101-4b and WJQ63. Together, these findings show the pivotal role of Nupr1 in both the initiation and late stages of PDAC in vivo, with a potential impact on PDAC cell stemness. <h3>Conclusions</h3> According to <i>Nupr1</i> status, <i>KIC</i> mice develop tumours that phenocopy human classical or QM-PDAC, respectively, and present differential drug sensitivity, thus becoming attractive models for preclinical drug trials.
<i>Circulation</i> Editors' Picks
Journal: Circulation (2011)

The following articles are being highlighted as part of Circulation's Topic Review series. This series will summarize the most important manuscripts, as selected by the editors, published in Circulation and the Circulation subspecialty journals. The studies included in this article represent the most read manuscripts published on the topic of arrhythmia and electrophysiology in 2009 and 2010.
Pneumatic dilation for achalasia: late results of a prospective follow up investigation
Authors: V F Eckardt
Journal: Gut (2004)

<b>Background and aims:</b> In this prospective study, we determined the long term clinical course of patients with achalasia who were treated by pneumatic dilation using the Browne-McHardy dilator, and determined whether previously described predictors of outcome remain significant after prolonged follow up. <b>Methods:</b> Between 1981 and 1991, 54 consecutive patients were treated by pneumatic dilation and followed up at regular intervals for a median of 13.8 years. Remission was determined with the use of a structured interview and a previously described symptom score. Duration of remission was evaluated by Kaplan-Meier estimates of time to recurrence. Predictors of outcome were determined using the log rank test. <b>Results:</b> Complete follow up until 2002 was obtained in 98% of all patients. Seven patients had died and were censored. A single pneumatic dilation resulted in a five year remission rate of 40% and a 10 year remission rate of 36%. Repeated dilations only mildly improved the clinical response. Patients who were older than 40 years had a significantly better outcome than younger patients (log rank test, p = 0.0014). However, the most significant predictive factor for a favourable long term outcome was a post-dilation lower oesophageal sphincter pressure of less than 10 mm Hg (log rank test, p = 0.0001). <b>Conclusions:</b> Long term results of pneumatic dilation are less favourable than previously thought. Young patients and those not responding to a single pneumatic dilation should be offered alternative therapy. Patients who remain in remission for five years are likely to benefit from the longlasting treatment effect of pneumatic dilation.
Erratum
Journal: BMJ (1894)

A. R. would be glad of references to standardlworks wherein hiccough is treated of.M.B., C Al., asks for advice in the treatment of a case of gleet of twelve months' duration.Injections of zinc sulphate, iodine, and silver niitr ate, iodoform bougies, blistering the perineum, and the passing of instrumenlts have been tried without benefit. RECURRENT ACNE ROSACEA.MEMBER would be glad to hear of suitable treatment of above in lady, aged 33.Congestion of the face occurs during or immediately after dinner, lasting some hours; it is greatly aggravated by cold or well diluted wines; the skin of the whole body very irritable; catamenia regular.Treatment adopted-careful diet, tonics, antidyspeptics, lead- lhas completely cured eruption but only to recur.
Errors in Key Points, Results, and Supplement
Journal: JAMA Network Open (2021)

Kari Risnes, MD, PhD; Josephine Funck Bilsteen, MSc; Paul Brown, PhD; Anna Pulakka, PhD; Anne-Marie Nybo Andersen, MD, PhD; Signe Opdahl, MD, PhD; Eero Kajantie, MD, PhD; Sven Sandin, PhD
Scientific Misconduct
Authors: Mark Levin
Journal: JAMA (1993)

<h3>To the Editor.</h3> —Ms Dresser<sup>1</sup>presents an argument for incorporating mental state concepts into the definitions of scientific misconduct. Thus, an "intent" to defraud would make a researcher culpable, whereas mere "sloppiness, laziness, and tendency to take unjustified shortcuts" would be left to the researcher's institution, guided by "documents" produced by the National Academy of Sciences panel and other professional groups. I strongly disagree. Incorporating judgments as to the offender's intent in the determination of their culpability is likely to land us in a morass of subjectivity and confuse both the researchers and the public. Such judgments have their place in the determination of the severity of sanctions but not of culpability. Deviant behavior should be clearly and explicitly defined; the punishment that is meted out can be adjusted according to the circumstances and motivations involved. That is how our legal system works, defining the crime and allowing the
Monilethrix: A Family Study
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Traumatic rupture of myocardium. Successful surgical repair
Authors: W. Bogedain
Journal: JAMA (1966)

NUMEROUS cardiac abnormalities may be produced by nonpenetrating trauma to the chest wall.<sup>1-4</sup>Accidents now rank first as a cause of death in the age group from 1 to 35. With the increasing sale of automobiles each year, it may be anticipated that the total number of cardiac injuries due to nonpenetrating trauma may also increase, and all physicians should be aware of the importance of early diagnosis. Lives may be saved by earlier recognition and surgical repair of cardiac tears or rupture from nonpenetrating trauma. Very little has been added to the literature since the reports of Beck and Bright<sup>5,6</sup>and Kissane et al<sup>7,8</sup>of their clinical and experimental work regarding nonpenetrating traumatic pathology to the heart. In a report from the Armed Forces Institute of Pathology in 1958, Parmley et al<sup>9</sup>described traumatic rupture of the heart. One of the most important single case
Efficacy and safety of glecaprevir/pibrentasvir in Japanese patients with chronic genotype 2 hepatitis C virus infection with and without cirrhosis
Authors: K. Chayama, F. Suzuki, K. Sato, T. Atarashi, T. Watanabe, H. Toyoda, M. Atsukawa, A. Naganuma, K. Notsumata, Y. Osaki, M. Nakamuta, K. Takaguchi, S. Saito, K. Kato, D.L. Pugatch, M. Burroughs, R. Redman, K. Alves, T. Pilot-Matias, B. Fu, H. Kumada
Journal: Journal of Hepatology (2017)
Thermoactivated price-label fume intolerance. A cause of meat-wrapper's asthma
Authors: R. H. Andrasch
Journal: JAMA (1976)

REACTIVE airway disease has been reported to occur with increased frequency among meat wrappers. Prolonged exposure to pyrolysates of polyvinyl chloride (PVC) soft-wrap films was initially implicated in the cause of this occupational disorder.<sup>1</sup>Severe asthma developed in a meat cutter after repeated occupational exposure to fumes of thermoactivated price-label adhesives. <h3>Report of a Case</h3> A 43-year-old man with a history of heavy cigarette smoking (45 cartons annually) was employed as a meat cutter for 25 years. He was asymptomatic until 1968 when he noted recurrent episodes of chest tightness and productive cough. Initially, these attacks developed only at work and appeared to be closely related to exposure to fumes of PVC meat-wrap film generated when the PVC resin was cut by the hot wire of the meat-wrapping console. His symptoms intensified at the end of the work week, decreased on weekends, and were virtually absent during vacation. In
RAISING THE DEAD.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PTU-187 Long-term quality of life after oesophagectomy for cancer: comparison of cervical vs mediastinal anastomoses
Authors: J M H Bennett, J Wormald, M Van Leuvan, M Lewis
Journal: Gut (2012)

<h3>Introduction</h3> With improvements in neoadjuvant therapy and earlier diagnosis, long-term survival after oesophagectomy for adenocarcinoma is becoming more frequent. With longer survival the quality of life (QOL) of patients post resection has become a greater priority. There has been extensive debate focusing on the long term effects of different sites for anastomosis. We aimed to examine if post-oesophagectomy QOL is affected by the site of the surgical anastomosis. <h3>Methods</h3> QORTC C-30 and OG-25 QOL questionnaires were analysed from post-oesophagectomy patients surviving &gt;3 years. Data were available both from a prospective database and questionnaires sent to post-oesophagectomy patients. Surgery was completed by two surgical teams and data were analysed in subsets dependant on the site of oesophago-gastric anastomosis—either thoracic or cervical. No patients underwent formal pyloroplasty. Data were analysed using the Student t test on SPSS statistical software. QORTC C-30 data were compared against the reference tables for oesophageal cancer pre-treatment and a cohort of pre-surgical patients awaiting oesophagectomy. Ethical approval was granted by the local MREC. <h3>Results</h3> A total of 60 patients responded (82%, anastomosis: thoracic n=29, cervical n=31) with a median time post-surgery of 6.1 years (range 3–12 years). Cervical and thoracic anastomosis subgroups were equivalent in terms of age at time of surgery, time post op and cancer stage. No significant QOL difference was noted between cervical or chest anastomosis groups for any functional or symptom score, especially focusing on dysphagia (OG25, p=0.24), odynophagia (OG 25, p=0.68) and swallowing problems (OG25, p=0.73). The patients9 overall general health (QL2) score was 72.0±19.43 (mean±SD) compared with 74.8±20.57 for a cohort of 53 NNUH pre-op oesophagectomy patients and 71.2±22.4 for the QORTC general population reference data. Functional indices and symptom scores are improved for our cohort compared to the QORTC oesophageal cancer reference baseline except symptom scores for diarrhoea and dyspnoea which worsen post-operatively. <h3>Conclusion</h3> There is no significant difference in QOL scores between oesophagectomy patients with cervical or thoracic anastomosis at &gt;3 years post-surgery when analysed using the QORTC C-30 and OG25 questionnaires. QOL in long-term survivors after oesophagectomy compares favourably with QORTC reference data for both pre-treatment oesophageal cancer and baseline general population data in our cohort, possibly due to the absence of pylorplasty. Further prospective QOL data collection is required to elucidate any long-term differences between the two anastomosis sites. <h3>Competing interests</h3> None declared.
Outbreaks of
Authors: M Cotch, R Janiszewski, K Klein, K Turczyn
Journal: JAMA (2005)

incomes Ն200% of the federal poverty level were more likely to see an eyecare provider during the preceding 12 months than children from families with incomes below poverty level (22.7% versus 17.0%).Approximately half (50.9%) of children aged 6-17 years were reported to participate in sports, hobbies, or other activities that can cause eye injury.Boys were more involved in activities that can cause eye injury than girls (60.8% versus 40.6%).In addition, as family income increased, participation in these types of activities also increased.Of children engaged in these activities, 14.6% were reported to use protective eyewear all or most of the time.Among those engaged in activities that can cause eye injuries, boys were more likely than girls to use protective eyewear (16.9% versus 11.1%).Use of protective eyewear did not vary significantly by race/ethnicity, income, or age group.
CONGENITAL SYPHILIS IN INSTITUTIONAL CHILDREN
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal