tbuckley/cabot-search huggingface dataset:
Pulmonary Mucormycosis
Authors: Leonardo Mejia Buritica, Amado J. Karduss Urueta
Journal: New England Journal of Medicine (2021)

A 51-year-old woman who had undergone bone marrow transplantation presented with pleuritic pain. Lung imaging revealed an area of ground-glass opacity surrounded by consolidation. Bronchoalveolar lavage was performed, and a diagnosis of mucormycosis was made.
A study of pelareorep in combination with pembrolizumab and chemotherapy in patients (pts) with relapsed metastatic adenocarcinoma of the pancreas (MAP).
Authors: Devalingam Mahalingam, Christos Fountzilas, Jennifer L. Moseley, Nicole Noronha, Karol Cheetham, Adrian Dzugalo, Gerard Nuovo, Andres Gutierrez, Sukeshi Patel Arora
Journal: Journal of Clinical Oncology (2018)

283 Background: Pelareorep (REOLYSIN) is a immuno-oncolytic virus (IOV) that induces an inflamed tumor phenotype secondary to viral infection of cancer cells. In combination with chemotherapy, it achieves 1 &amp; 2 year-survival rates of 46% &amp; 24% in MAP pts, respectively. Tumor analysis from pts showed reovirus protein replication, T-cell infiltration and upregulation of PD-L1. Similarly, the combination of pelareorep with anti-PD-1 antibody documented survival benefit in a pre-clinical model. We hypothesized that pelareorep in combination with chemo and pembrolizumab in pts with MAP would be clinically efficacious. Methods: A phase 1b study enrolled MAP pts who progressed after first line treatment. Pts received pelareorep (4.5 x 10 10 TCID 50 IV, D1 &amp; D2), plus pembrolizumab (2mg/kg IV, D8) plus either 1)5-FU (LV (200 mg/m 2 /5-FU 200 mg /m 2 IV bolus, 5-FU 1200mg/m 2 continuous IV infusion D1) or 2) gemcitabine (1000 mg/m 2 IV, D1), or 3) irinotecan (125 mg/m 2 IV, D1) q3w, until disease progression/unacceptable toxicity. The primary endpoint was safety. Secondary objectives included tumor response &amp; evaluation for reovirus replication/immune analysis. Results: 11 pts were enrolled with pelareorep, pembrolizumab and gem (n = 6), 5-FU (n = 3), or iri (n = 2). Most common grade 1 or 2 TEAEs include: fever (73%), headache (55%), chills (46%), dehydration (36%), fatigue (27%) and anemia (27%). One pt (gem arm), transient Gr 2 increased transaminases was reported on two occasions. Grade 3 or 4 TEAEs occurred in 8 pts (73%): abdominal pain, anemia, arthralgias, biliary obstruction, chills, DVT, diarrhea, fever, hyperglycemia, leukopenia, myalgias, nausea, neutropenia, pulmonary emboli, urinary tract infection and vomiting. Of the 5 efficacy evaluable pts, one had PR (13.8 m duration) and 2 SD (lasting 126 and 277 days). Eight died secondary to PD. On-treatment biopsy show reovirus infection in cancer cells and immune infiltrates. Conclusions: The combination therapy showed manageable safety profiles and antitumor activity in previously treated MAP pts. Further evaluation of anti-tumor activity of pelareorep and anti-PD-1 antibody ± chemotherapy combos is planned. Clinical trial information: NCT02620423.
How to report randomized controlled trials. The CONSORT statement
Authors: D. Rennie
Journal: JAMA (1996)

The best evidence on the efficacy of medical interventions comes from well-conducted, randomized controlled trials (RCTs), but unless such trials are reported adequately, it is impossible to assess that information. In response to increasing evidence that reporting of RCTs is imperfect, there has been a concerted effort to set standards for reporting RCTs, the process described by Begg et al<sup>1</sup>in this issue ofTHE Journal. See also p 637. In December 1994,<i>JAMA</i>published the Standards of Reporting Trials (SORT) statement.<sup>2</sup>We followed this with the publication of a trial using all the SORT headings.<sup>3</sup>In an accompanying Editorial,<sup>4</sup>I called for the SORT group to agree on common standards with another group that had met in Asilomar.<sup>5</sup>Representatives of both groups were brought together by David Moher, MSc, of the University of Ottawa. Their discussions were informed by comments from readers, many of
Hepatology Highlights
Authors: Jean‐François Dufour
Journal: Hepatology (2016)

Biliatric" SurgeryBariatric surgery enables obese patients not only to lose weight, but also correct their metabolic abnormalities.After vertical sleeve gastrectomy, the rapid metabolic benefits are not explained by the restrictive nature of the surgery.Bile acids have many properties; among others, they are signaling molecules that affect metabolism.They do this through two receptors: the farnesoid X receptor and the transmembrane G-protein-coupled receptor 5 (TGR5).Ding et al. performed vertical sleeve gastrectomy in wild-type mice and in TGR5 -/-mice, which were fed a high-fat diet.In the initial weeks after the procedure, the TGR5 -/-mice lost weight like the wild-type mice.However, at week 14, they had regained weight, in contrast to the wild-type mice.The beneficial effects on glucose tolerance and insulin sensitivity were lost.In wild-type mice and in TGR5 -/-mice, the bariatric surgery increased the circulating levels of bile acids.This work nicely demonstrates the crucial role of bile acids and their receptor, TGR5, after bariatric surgery.
VACCINATION AGAINST TUBERCULOSIS WITH LIVING BACILLI
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Incorrect Language
Journal: JAMA (2014)

Rebecca Vigen, MD, MSCS; Colin I. O’Donnell, MS; Anna E. Barón, PhD; Gary K. Grunwald, PhD; Thomas M. Maddox, MD, MSc; Steven M. Bradley, MD, MPH; Al Barqawi, MD; Glenn Woning, MD; Margaret E. Wierman, MD; Mary E. Plomondon, PhD; John S. Rumsfeld, MD, PhD; P. Michael Ho, MD, PhD
Medical Audit
Authors: Paul S. Berman
Journal: JAMA (1977)

<h3>To the Editor.—</h3> Rosenberg's COMMENTARY entitled "Medical Audit JCAH Style: A Negative View" (237:1935, 1977) is inaccurate in its evaluation of the Performance Evaluation Procedure (PEP) system. The PEP system incorporates process elements with the reservation that they be related to outcome or the welfare of the patient. It abhors the use of process lists that lead to a detrimental type of cookbook medicine. Rosenberg has confused the term "critical process element" with "process audit." Ms Dixon's letter (mentioned by Rosenberg) described those set of circumstances where a process audit could be used for problem-solving. The length-of-stay indicator (LOS) is but one mechanism to evaluate quality of care. It also helps to relate audit to utilization review. In the PEP system it is but a very small part of the whole program. The PEP system is only boring to those who do not understand how to use it properly. It
Pathologische Physiologie des Chirurgen.
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cigarette Smoking Among Youth—1989
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE INFLUENCE OF DIET UPON THE REGENERATION OF SERUM PROTEIN
Authors: Daniel Melnick, George R. Cowgill, Ethel Burack
Journal: The Journal of Experimental Medicine (1937)

Page 889, 16th line from bottom, for 52.1 read 56.4; for 22.7 read 27.0. 13th line from bottom, for 43 read 52. 7th line from bottom, for 13.0 read 17.8. 6th line from bottom, for 29 read 40. Page 890, 3rd line from the top, for 12.5 read 13.3. 4th line from the top, for "This value, approximately 34 per cent of the total circulating serum protein, agrees very well with those recorded for dogs 3 and 4," read "This value is approximately 36 per cent of the total circulating serum protein. During the initial depletion week, 38.0 gm. of serum protein were removed from this animal." 20th line from top, for 30 to 40 read 35 to 55. Page 895, 2nd line in 3rd paragraph under Summary, for 30 to 40 read 35 to 55.
Abstract P064: Association of Cardiorespiratory Fitness and Submaximal Blood Pressure Among Young Healthy Men- A Reverse J-curve Pattern Relationship
Authors: Vivek K Prasad, Clemens Drenowatz, Gregory A Hand, Carl C Lavie, Xuemei Sui, Madison Demello, Steven N Blair
Journal: Circulation (2015)

Objectives: Exaggerated blood pressure (BP) response during exercise is an important marker of cardiovascular events that are associated with incident hypertension, atherosclerosis, myocardial infarction, coronary artery disease and stroke. Cardiorespiratory fitness (CRF) is associated with a lower risk of all-cause and cardiovascular disease (CVD) mortality. The purpose of this study was to examine the association between CRF and submaximal BP at various stages of Graded Exercise Test (GXT) in young healthy men. Methods: GXT using a Modified Bruce protocol on a treadmill was performed on 191 normotensive (resting BP &lt; 140/90 mm Hg) men aged 20-35years. BP was recorded at each stage of the protocol. Quintiles of fitness were established on the basis of peak Vo2 with the 1 st quintile being the lowest fit group and 5 th quintile being the highest fit group. Results: The mean peak Vo2 in quintiles 1, 2, 3, 4 and 5 were 32.3, 39.1, 43.4, 48.1 and 55.5 respectively. A reverse J-curve pattern relationship was evident between CRF and submaximal systolic BP. Men in the 3 rd quintile displayed the lowest submaximal systolic BP levels across all the stages of GXT. There was a substantial decrease in submaximal BP from quintile 1 to 3 followed by an increase in higher quintiles, although still lower than quintile 1. The J-shaped relationship remained significant after controlling for potential confounders, including age, race, body fat percentage, resting systolic BP, smoking and alcohol intake (Quadratic trend P value&lt; 0.05). Conclusion: These findings suggest that in young healthy men, there is a reverse J-curve pattern relationship between submaximal BP and CRF. Improving the CRF from low to average to high will progressively decrease submaximal systolic BP and CVD risks. However, the benefits from improvements in the CRF and prevention of increased submaximal systolic BP plateau at a point, beyond which there are no additional benefits or loss of the benefits (in a reverse J-curve pattern).
NONOPERATIVE CARDIAC RESUSCITATION
Journal: JAMA (1961)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Neurology
Authors: M. van Allen
Journal: JAMA (1979)

<h3>Stroke: Its Prevention, Its Treatment</h3> Stroke, risk factors for degenerative vascular disease, and transient ischemic attacks (TIAs) continue to be major preoccupations of those in neurology. The majority of TIAs seem to be due to forward embolism from atheromatous plaques in the major vessels. Endarterectomy, anticoagulant agents, and platelet antiaggregating drugs (aspirin, sulfinpyrazone, dipyridamole) are the available modalities for treatment after cardiac and hematologic disorders have been eliminated as causes for circulatory insufficiency. Millikan and McDowell<sup>1</sup>have provided an excellent review of the subject. When angiography demonstrates an atheromatous plaque at the carotid bifurcation, many investigators prefer surgical treatment. Still, however, the risks of both angiography and surgery must be weighed, and we have as yet no consensus on the long-term advantages of surgical operation over medical treatment.<sup>2,3</sup>The frequency of TIAs can be reduced if anticoagulants such as heparin sodium and warfarin sodium are used early on,
NAFLD fibrosis score identifies not only advanced liver fibrosis but also chronic vascular complications in type 2 diabetic patients
Authors: Rosa Lombardi, Lorena Airaghi, Giovanni Targher, Gaetano Serviddio, Gabriele Maffi, Alessandro Mantovani, Claudio Maffeis, Antonio Colecchia, Rosanna Villani, Luca Rinaldi, Emanuela Orsi, Giuseppina Pisano, Luigi Elio Adinolfi, Silvia Fargion, Anna Ludovica Fracanzani
Journal: Journal of Hepatology (2020)
MODL-06. PRECLINICAL EFFICACY OF THE IMIPRIDONE ONC-206 AGAINST MEDULLOBLASTOMA
Authors: Anshu Malhotra, Jingbo Liu, Hongying Zhang, Minhui Ma, Jose Velazquez Vega, Matthew Schniederjan, Varun Prabhu, Joshua Allen, Tobey MacDonald
Journal: Neuro-Oncology (2020)

Abstract Treatment for medulloblastoma (MB) is typically ineffective for MYC amplified or metastatic SHH, Group 3 and 4 subgroups. Promising preclinical and clinical results have been obtained in brain cancers treated with ONC-201, a selective antagonist of DRD2, a G-protein coupled receptor that regulates prosurvival pathways. Herein, we report the activity of ONC-201 and ONC-206, which has increased non-competitive antagonism of DRD2, against MB. We treated three different MB cell types representative of SHH- and Group 3-like cells, with varied levels of DRD2 expression, and consistently observed increased cell death in a dose-dependent manner at lower doses of ONC-206 compared to ONC-201. We also evaluated ClpP as an additional drug target in MB. ClpP is a mitochondrial protease that has been shown to directly bind and be activated by ONC 201, and is highly expressed at the protein level across pediatric MB, malignant glioma and ATRT, but not normal brain. We observed that similar to ONC-201, ONC-206 treatment of MB cells induces the restoration of mitochondrial membrane potential to the non-proliferative state, degradation of the mitochondrial substrate SDHB, reduction in survivin and elevation in ATF4 (integrated stress response). Importantly, ONC-206 treatment induced significant cell death of patient-derived SHH, WNT, and Group 3 tumors ex vivo and Group 4 cells in vitro, while having no observable toxicity in normal brain. Efficacy studies of ONC-206 against MB in vivo will be reported in preparation for a planned Phase I study of ONC-206 in children with malignant brain tumors.
Neurological Surgery
Authors: Russel H. Patterson
Journal: JAMA (1985)

One of the favorite pastimes of health planners is predicting the health manpower needs of the country five or ten years in advance. Of the various methods used, a recent popular technique involves "Delphi panels." Instead of peering at sheep entrails, the modern Delphi panelist charts the growth of the population and the growth of the number of specialists, couples these with statistics on how busy specialists are at the time, and then predicts future needs. The problem with this technique is that a new operation can alter the statistics dramatically. Ten or 15 years ago, cardiac surgery seemed to be dwindling because congenital defects were few in number and rheumatic fever was infrequent. Arrival of the coronary artery bypass procedure revitalized the specialty and made all prior predictions of need obsolete. Members of all specialties harbor the hope that a new procedure will dramatically increase demands for their services.
EPIDEMIC CEREBROSPINAL MENINGITIS.
Authors: W. J. CLASS
Journal: JAMA (1899)

<h3>INTRODUCTION.</h3> The objects which led to the investigation of which this report is the outcome were: 1, to ascertain whether true epidemic cerebrospinal meningitis existed in the city of Chicago, and 2, to trace if possible its origin and the avenues by which it spread. In regard to the first of these objects, it was soon discovered that there was a greater prevalence of the disease than was generally supposed, and enough data were collected, which we hope are of sufficient interest to the general practitioner, to excuse the writer for encroaching on those particulars of the disease which, strictly speaking, do not perhaps belong to the territory of the sanitarian. Chicago has for a number of years fortunately escaped the ravages of a disease which has been in a constantly increasing number of instances prevalent throughout a large part of the country, particularly in its eastern portion. There is
Pioneers of medical teaching in the Province of Quebec
Authors: S. Leblond
Journal: JAMA (1967)

Under the French regime (circa 1600-1763). medical education did not exist other than through apprenticeship. According to Nadeau,<sup>1</sup>only three men were in possession of a valid physician's or surgeon's diploma. They were Jean Bonamour, Antoine Briault, and Michel Sarrazin. All the others were barber-surgeons or assistants, trained in France before they left that country, or men who had been assistants to barber-surgeons, with no other training. Michel Sarrazin, a barber-surgeon, returned to France, and after two years of medical studies in Reims, he received a degree of doctor of medicine from the medical school of that city. Although the King of France appointed Jean Madry, Jean Demosny, Michel Sarrazin, and Jourdain Lajus as master barber surgeons, no formal instruction was available in New France other than by apprenticeship. In the majority of cases, sons were apprenticed to their fathers, as evidenced by the names of Alavoine, father and
ALONZO GARCELON.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Modern Views on the Toxaemias of Pregnancy.
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal