tbuckley/cabot-search huggingface dataset:
Erratum: High-throughput Three-dimensional Gel Electrophoresis for Versatile Utilities: A Stacked Slice-gel System for Separation and Reactions (4SR)
Authors: Md. Salimullah, Masaki Mori, Koichi Nishigaki
Journal: Genomics Proteomics & Bioinformatics (2006)

PHProteomicDB identification.php3)to add HTML codes for style or decoration.As an example, the module displays 2-DE gels of human umbilical vein endothelial cells at http: //www.huvec.com/index.php3?rub=2Dpattern.What distinguishes our work from others is that it allows researchers that are newcomers in web site management to benefit from the power and the flexibility of the PHP dynamic language and the efficient use of databases.For people who are reluctant to use complex tools such as the Make 2D-DB I1 package ( 2 ) , which is a federated database for 2-DE users, PHProteomicDB is a smartly way to display updated personal 2-DE data on the web.The development of the module is being pursued with future updates with the latest version available on our web site at http://www.huvec.com/index.php3?rub=Download.
Error in Tables
Journal: JAMA Surgery (2019)

Shashank Sarvepalli, MD, MS; Ari Garber, MD, EdD; Michael B. Rothberg, MD, MPH; Gautam Mankaney, MD; John McMichael, BS; Gareth Morris-Stiff, MD, PhD; John J. Vargo, MD, MPH; Maged K. Rizk, MD; Carol A. Burke, MD
From the National Institutes of Health
Authors: B. Healy
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AIDS
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Future Directions in Epidemiologic Studies of 1,3-Butadiene-Exposed Workers
Authors: John F. Acquavella
Journal: Environmental Health Perspectives (1990)

To date, epidemiologic research on 1,3-butadiene has consisted of cohort mortality studies of workers in the styrene-butadiene rubber (SBR) and butadiene monomer industries. These studies have been extremely useful both in defining the focus on human health effects to the lymphopoietic cancers and in providing a perspective on which to evaluate the available animal models for human risk assessment. The next step for epidemiologic research will involve a lymphopoietic cancer case control approach to enable a more precise assessment of whether there is a relationship between 1,3-butadiene exposure and lymphopoietic cancer. In addition, periodic mortality updates of the 1,3-butadiene-exposed worker cohorts will be important to monitor trends in lymphopoietic cancer rates and to ensure that other cancers with long latency do not begin to show elevated rates. This paper describes an industry-sponsored program of case-control and cohort mortality update studies along with the critical elements in research design and analysis for each study. Epidemiological studies will play an important role in testing hypotheses developed from toxicological studies about potential biological mechanisms of 1,3-butadiene carcinogenesis in humans.
GI highlights from the literature
Authors: Mairi H McLean
Journal: Gut (2011)

We describe the identification and initial characterization of neurobeachin, a neuron-specific multidomain protein of 327 kDa with a high-affinity binding site (<i>K</i><sub>d</sub>, 10 nm) for the type II regulatory subunit of protein kinase A (PKA RII). Neurobeachin is peripherally associated with pleomorphic tubulovesicular endomembranes near the <i>trans</i>sides of Golgi stacks and throughout the cell body and cell processes. It is also found in a subpopulation of synapses, where it is concentrated at the postsynaptic plasma membrane. In live cells, perinuclear neurobeachin is dispersed by brefeldin A (BFA) within 1 min, and in permeabilized cells a recruitment of neurobeachin from cytosol to Golgi-near membranes is stimulated by GTPγS and prevented by brefeldin A. Spots of neurobeachin recruitment are close to but distinct from recruitment sites of COP-I, AP-1, and AP-3 coat proteins involved in vesicle budding. These observations indicate that neurobeachin binding to membranes close to the<i>trans</i>-Golgi requires an ADP-ribosylation factor-like GTPase, possibly in association with a novel type of protein coat. A neurobeachin isoform that does not bind RII, beige-like protein (BGL), is expressed in many tissues. Neurobeachin, BGL, and ∼10 other mammalian gene products share a characteristic C-terminal BEACH-WD40 sequence module, which is also present in gene products of invertebrates, plants, protozoans, and yeasts, thus defining a new protein family. The prototype member of this family of BEACH domain proteins, lysosomal trafficking regulator (LYST), is deficient in genetic defects of protein sorting in lysosome biogenesis (the<i>beige</i> mouse and Chediak-Higashi syndrome). Neurobeachin9s subcellular localization, its coat protein-like membrane recruitment, and its sequence similarity to LYST suggest an involvement in neuronal post-Golgi membrane traffic, one of its functions being to recruit protein kinase A to the membranes with which it associates.
Assessment and training of physicians in the “art of oncology”: Results from a psychosocial seminar in first-year of fellowship
Authors: A. B. Moadel, E. Greenwald
Journal: Journal of Clinical Oncology (2004)

6039 Background: In an effort to identify and address the psychosocial training needs of oncology fellows in an urban cancer center, a Psychosocial Needs Survey and Seminar were developed and implemented. Methods: Between 1998–2003, all oncology fellows (n=38) were assessed at the year's start about their self-reported frequency and comfort in discussing several psychosocial issues with patients. They then attended a monthly or biweekly, 10-session psychosocial seminar taught by an oncologist and health psychologist after which they were re-assessed (n=27). Results: The fellows indicated they discussed the following issues \(\underline{\mathrm{never\ or\ at\ initial\ visit\ only}}\) according to pre- and post-seminar assessment, respectively: psychological services (22% vs 0%, p<0.020); sexual functioning (69% vs 48%); patient's beliefs about cancer/treatment (28% vs 14%); spiritual/religious services (61% vs 45%); and alternative medicine (47% vs 43%). Based on pre- and post-seminar, fellows reported \(\underline{\mathrm{discomfort}}\) in discussing poor prognosis (33% vs 10%, p=0.044); lack of treatment options (50% vs 24%, p=0.052); end-of-life issues (39% vs 10%, p=0.017); initial diagnosis: (22% vs 5%); sexual functioning (43% vs 33%); emotional adjustment (14% vs 5%); alternative medicine (46% vs 25%); and spiritual issues (29% vs 35%). Most (82%–100%) fellows found the seminar topics "informative/very informative", with the readings, videos, discussion, role-playing, relaxation exercises described as "helpful/very helpful" by 72%–96%. Conclusions: Based on self-reported patient care practices, first-year oncology fellows demonstrate room for growth in the "art of oncology". Results suggest that psychosocial training exposure throughout the first year of fellowship may raise physicians' awareness and comfort in addressing psychological support and advanced disease issues. Further exploration regarding attitudes and barriers to addressing spiritual needs, sexual functioning, and alternative medicine is warranted. No significant financial relationships to disclose.
Allergic Contact Sensitizing Chemicals as Environmental Carcinogens
Authors: Roy E. Albert
Journal: Environmental Health Perspectives (1997)

Chemicals that were bioassayed by the National Toxicology Program (NTP) and that also produce allergic dermatitis (ACD) in humans were evaluated for their tumorigenic characteristics. The impetus for the study was that most contact sensitizers, i.e., those that produce ACD, and genotoxic carcinogens are chemically similar in that they are electrophilic, thereby producing adducts on macromolecules including protein and DNA. This similarity in chemical behavior suggests that many contact sensitizers might be environmental carcinogens. All of the published NTP bioassays by early 1996 that had both genotoxicity and carcinogenicity studies were included in this analysis. The NTP chemicals had been chosen for bioassay without regard to their ability to produce ACD. Of the 209 chemicals that were bioassayed, there were 36 (17%) that were known to be human contact sensitizers; about half of these were positive on tumor bioassays. The contact sensitizers differed from the NTP sample as a whole by having a proportionately larger number of nongenotoxic chemicals by the Ames Salmonella assay, presumably because more of them were selected on the basis of widespread usage rather than structural resemblance to known carcinogens. Compared to the nongenotoxic chemicals, the genotoxics were stronger carcinogens in that they had a higher incidence of positive tumor bioassays, with twice the number of organs in which tumors were induced. The nongenotoxic chemicals had a preference for tumor induction in parenchymal tissues in contrast to epithelial tissues. The contact sensitizers showed essentially the same characteristics as the whole NTP sample when stratified according to genotoxicity. Judging by the chemicals that were chosen primarily for their widespread use rather than for their structural resemblance to carcinogens, the addition of a test for contact sensitization to the Ames test as a screening tool would increase the tumorigenic detection efficiency by about 40% because of the nongenotoxic tumorigens. A ballpark estimate suggests that there could be several thousand contact sensitizers for humans in commercial use that are rodent tumorigens.
Occupational Asthma with Paroxysmal Atrial Fibrillation in a Diamond Polisher
Authors: Elizabeth Wilk-Rivard, Jaime Szeinuk
Journal: Environmental Health Perspectives (2001)

We present a case of a diamond polisher who developed occupational asthma as a result of prolonged exposure to various potent and well-recognized asthma-inducing agents, including cobalt dust. Although the patient was seen by various medical professionals during the initial course of his illness and given an early diagnosis of a respiratory condition, there were no attempts to evaluate the nature of his work, and therefore to establish a possible causal relationship with his exposures. This case clearly illustrates the importance of such an assessment. The ultimate fate of this patient (he had to retire from his job with a chronic and permanent illness) could have been avoided by early environmental intervention. In addition, this case illustrates a possible complication of asthma, that is, a severe cardiac arrhythmia. In this case, both the patient's symptoms and the prescribed medications contributed to worsening of the patient's underlying condition. Early diagnosis and intervention of this patient's work practices could have avoided this complication.
银屑病的睡眠障碍
Authors: P. Jensen, C. Zachariae, L. Skov, R. Zachariae
Journal: British Journal of Dermatology (2018)

银屑病是一种常见的皮肤病,影响全世界约 4‐5% 的人。银屑病可以通过皮肤上的红色、鳞屑区域进行识别,并且最常见的部位是肘部、膝盖、头皮和下背部。鉴于这些身体症状,有人可能怀疑银屑病患者可能有睡眠困难。这项来自丹麦哥本哈根的研究旨在研究银屑病患者的睡眠障碍。研究对象包括 179 名银屑病患者和 105 名没有银屑病的患者,他们都完成了关&`#x4E8E;睡眠质量的问卷调查。25% 的银屑病患者有睡眠障碍,超过一半的患者可归为睡眠不良者。这些数字远高于未患银屑病的人群中的数据。此外,作者还发现皮肤瘙痒是银屑病患者睡眠质量下降的主要原因。
Course of Clinical Lectures: Delivered at the Middlesex Hospital
Authors: None Watson
Journal: BMJ (1842)

GENTLEMEN,-Although sixty-three patients were discharged from the hospital on Tuesday, the 6th inst.-the largest dismissal that I remember in any single week-so many new patients were admitted during the ensuing week, that only a few beds were left vacant for me on Tuesday last; and as many appli- cants were rejected, I believe, from want of room, as were actually received into the wards.The number actually admitted by me has been fourteen-six women and eight men.I proceed, ac- cording to my custom, to give you a summary account of these.
Strophanthintherapie zugleich ein Beispiel quantitativer Digitalisanwendung nach pharmakologischen Grundsätzen
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Liver cirrhosis development and value of transient elastography among a large cohort of Wilsońs disease patients with a long-term follow-up in Spain
Authors: Zoe Mariño, Antonio Olveira Martin, Anna Pocurull, Loreto Hierro, Concepció Bartres, Pilar Castillo, Virginia Hernandez-Gea, Francisco Javier Garcia-Samaniego Rey, Celia Badenas, Xavier Forns
Journal: Journal of Hepatology (2020)
WHERE GLUCOSE IS WELCOMED
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
HIV antibody testing: summary of BMA guidance
Journal: BMJ (1987)

The 1987 annual representative meeting of the British Medical Association (BMA) passed a motion stating that "testing for HIV antibodies should be at the discretion of the patient's doctor, and should not necessarily require the consent of the patient." Concerned that such a policy might subject doctors to criminal or civil action or to complaints of medical misconduct, the BMA sought guidance from legal counsel concerning the need for consent by patients to taking samples for investigation in the doctor's office. The guidance summarized here advises that, except in emergency situations, the carrying out of an HIV antibody test requires the informed consent of the patient, based on full disclosure of what the doctor intends to do. The doctrine of implied consent is not likely to be held to cover testing for HIV antibody. Practitioners concerned about the risk of AIDS infection should treat any patient who refuses to give consent as if the patient were infected.
Metformin
Authors: Oscar B. Crofford
Journal: New England Journal of Medicine (1995)

We now have another drug for the treatment of patients with non-insulin-dependent diabetes mellitus (NIDDM). After more than a decade of clinical experience in Europe, Canada, and other countries,1,2 the Food and Drug Administration (FDA) has approved metformin, marketed in the United States as Glucophage. Much of the FDA's caution can be attributed to the chemical similarity between metformin and phenformin, a drug that was used extensively in the 1960s but removed from the U.S. market in 1977 because of the excessive occurrence of lactic acidosis in patients treated with it.This issue of the Journal contains two articles . . .
Frequency and types of medical emergencies among commercial air travelers
Authors: R. O. Cummins
Journal: JAMA (1989)

We performed a one-year prospective survey of emergency medical responses to travelers at an international airport to observe the frequency and type of emergencies experienced in flight and before and after travel. Emergency personnel evaluated a total of 1107 people; 754 (68%) were travelers, 232 (21%) were employees of the airport or airlines, and 118 (11%) were area residents. Of the 754 travelers, 190 (25%) experienced their problem during flight; the aircraft made an unscheduled landing for seven of these travelers. The frequency of in-flight emergencies was 1 per 753 inbound flights, or 1 per 39 600 inbound passengers. The most common emergency problems among all travelers were abdominal pain, chest pain, shortness of breath, syncope, and seizures; 25% of the emergencies were caused by minor trauma. The majority of emergencies among air travelers (75% [564/754]) happened on the ground within the air terminal. Most problems (84% [633/754]) were effectively handled by personnel trained as emergency medical technicians. The types of problems encountered suggest that the "doctors only" medical kit now required aboard US air carriers contains clinically useful items and should continue to be required on board. <i>JAMA</i>1989;261:1295-1299)
Bladder fistula
Authors: R. A. Mintzer
Journal: JAMA (1977)

<h3>Common1</h3> Congenital anal atresia Crohn's disease Diverticulitis Malignant neoplasm of colon, bladder, or reproductive system Postoperative or postpartum complications Radiation therapy Trauma <h3>Uncommon</h3> Appendicitis Embedded stone eroding through bladder wall Foreign body Lymphogranuloma venereum Pelvic inflammatory disease, endometritis Schistosomiasis Tuberculous enterocolitis Ulcerative colitis <h3>Diagnosis</h3> Intestinovesical fistula secondary to Crohn's disease. <h3>Comment</h3> Figure 1, roentgenogram of the pelvis obtained with the patient in the supine position during an intravenous pyelogram, demonstrates a collection of gas in the urinary bladder and an irregular filling defect in the superior wall of the bladder. Figure 2 is a selected view from a combined barium examination of the small bowel and colon demonstrating an ulcerated stenotic loop of ileum with a fistulous communication to the urinary bladder and a colovesical fistula. Figure 3 is a roentgenogram of
The use of nonsteroidal anti-inflammatory agents
Authors: R. F. Willkens
Journal: JAMA (1978)

NONSTEROIDAL anti-inflammatory agents take their origin in antiquity, and despite their extensive proliferation, they remain empirical forms of therapy. The inflammatory reaction, once remembered by students of pathophysiology as a tetrad of Greek terms, is now defined as a series of interacting biochemical pathways that include inflammatory mediators, the complement cascade, the coagulation intermediates, and fixed and migrating reactive cells. The aim of treatment with anti-inflammatory agents as such is to control rather than eliminate the inflammatory response. Where the stimulus, or provocation, is recognized, it becomes relatively easy to turn off this reaction. Similarly, when a specific mediator or cell can be identified, such as histamine or the mast cell, agents directed at these elements of inflammation can intercept and modify the harmful effects of this reaction. Unfortunately, most of the disorders for which anti-inflammatory agents are useful have undefined causes, and treatment is directed at the overall response
Gift
Authors: Terry S. Johnson
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal