tbuckley/cabot-search huggingface dataset:
BURNS AND SILVER NITRATE
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Grant Writing
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Transaminase Levels in the Postconvalescent Phase of Infectious Hepatitis
Authors: David M. Reisler
Journal: JAMA (1967)

Forty-one persons, mostly children, were followed up with serial serum glutamic pyruvic transaminase (SGPT) determinations for 6 to 12 months after onset of acute infectious hepatitis. An abnormal level was observed in the postconvalescent period in 12 (29%) of these. Most children with SGPT abnormality were asymptomatic; among the few with mild residual complaints, there appeared to be no necessary correlation with SGPT level. Observations made approximately one year after onset did not suggest that chronic hepatitis had developed within that interval in any of the children. It does not appear that SGPT abnormality is a reason by itself for reinstituting bed rest or restricting activity.
Morbidity—Not Mortality—Best Criterion For Judging Value of Anticoagulants
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The enigmas of pigmentation
Authors: M. F. Allende
Journal: JAMA (1972)

Melanin pigmentation plays an important part in adaptation to the environment. It protects against the carcinogenic effects of actinic radiation. As man migrated away from the tropics, the lightening of the species might have been due to a decreased need for this protection as well as to the need of a lighter skin to allow proper synthesis of vitamin D. New adaptations to sunnier climates might be accompanied by reverse darkening. The reason for the darkening of hair from infancy into adulthood needs studying as well as the differences in texture and coloring between scalp and beard hair. The sociological implications of skin pigmentation are serious. Sufferers from pigmentary disturbances need strong emotional support in addition to the standard forms of treatment.
Anesthesiology
Authors: E. M. Papper, S. H. Ngai
Journal: New England Journal of Medicine (1954)

THE development of anesthesiology since World War II has been characterized by several distinct paths of clinical and scientific activity. Efforts have been made to provide better clinical anesthetic care for more patients by the strengthening of residency training programs. Aid has been given the surgeon in his desire to extend operative treatment to previously inaccessible organs, such as the heart, and to patients whose risk for operation was considered prohibitive two decades ago. However, these twin activities depend on the acquisition of basic knowledge concerning physiologic derangements in the anesthetized state regardless of the specific anesthetic agent employed. This . . .
Military medicine's role continues in Bosnia
Authors: P. Gunby
Journal: JAMA (1996)

IT APPEARS that US military medicine will be at work in Bosnia-Herzegovina beyond the 1-year stay, originally expected to end December 20,1996, that had been announced for American troops participating in the North Atlantic Treaty Organization (NATO) peace-enforcement effort. Some 5000 US soldiers moved into the former Yugoslavia last month from bases in Germany. This, the Pentagon says, is the covering force for withdrawal of 15 800 US military people, many of whom were in place December 20,1995, when the 52000-troop NATO force assumed the peace-enforcement duties from the United Nations (<i>JAMA</i>. 1996;275:24). The new arrivals are expected to stay until mid-March 1997, although some diplomats contend that NATO forces will have to remain in the region for at least 2 more years if the civil war is not to resume. Military physicians are watching the newcomers closely until they acclimatize, because the tick season does not end until later
To change or not to change a name
Authors: W. R. Barclay
Journal: JAMA (1980)

What's in a name? The people at the Center for Disease Control (CDC), Atlanta, may agree that a rose by any other name would smell as sweet, but they are not equally comfortable with the proposal that bacteria can be renamed without unanimous consent of the scientific community.<sup>1</sup>The judicial commission of the International Committee of Systematic Bacteriology is considering a proposal by Lapage<sup>2</sup>that the family name Enterobacteriaciae be discarded in favor of Enterobacteraciae and that the type genus of the family be changed from<i>Escherichia</i>to<i>Enterobacter</i>. Although these may be semantic reasons, there are no pressing needs for these changes. Most physicians would not recognize Enterobacteriaciae if they encountered them in a Petri dish, but they do recognize<i>Escherichia</i>when named on a laboratory report, and they then associate the patient's problem with the name. There is some virtue in constancy, especially in the matter
Reply
Authors: James Hamilton, Svetlana Lutsenko
Journal: Hepatology (2016)

Potential conflict of interest: Nothing to report. Reply: We would like to thank you for your interest in our article. We agree that our article, and the work of others,1 has shed a new light on the role of nuclear receptor signaling, and especially liver X receptor/retinoid X receptor (LXR/RXR) activation as a relatively early response to copper misbalance. We propose that drug‐mediated improvement of liver disease in the Wilson disease (WD) mice involves activation of LXR/RXR function not only in hepatocytes, but also in nonparenchymal liver cells (NPCs). Our findings suggest that copper overload negatively regulates LXR and RXR. The mechanisms underlying this regulation by copper remain to be fully elucidated. However, the implication that NPCs are involved in the pathogenesis of WD is an exciting new finding. Investigation of the cross‐talk between hepatocytes and stellate cells/Kupffer cells in this animal model may have ramifications for all fibrotic liver diseases. Although T0901317 was first reported to be a specific LXR agonist,4 we agree that the drug may target other nuclear receptors that form heterodimers with RXR. In fact, it could be that the pleotropic effect of the drug accounts for beneficial anti‐inflammatory and antifibrotic effects that we observe in WD mice. Identifying all targets of T0901317 in the WD model is an important future goal. Future modifications of the drug and/or careful evaluation of dosage/time of treatment are also likely to be necessary to offset the potential untoward effects (such as hepatic steatosis). Nonetheless, modulation of LXR activity appears to have promise as a novel therapy for WD.
Authors' reply
Authors: S C Darby, R Doll, G M Kendall
Journal: BMJ (1994)

<h3>Abstract</h3> The key to limiting SARS-CoV-2 spread is to identify virus-infected individuals (both symptomatic and asymptomatic) and isolate them from the general population. Hence, routine weekly testing for SARS-CoV-2 in all asymptomatic (capturing both infected and non-infected) individuals is considered critical in situations where a large number of individuals congregate such as schools, prisons, aged care facilities and industrial workplaces. Such testing is hampered by operational issues such as cost, test availability, access to healthcare workers and throughput. We developed the SalivaDirect RT-qPCR assay to increase access to SARS-CoV-2 testing via a low-cost, streamlined protocol using self-collected saliva. To expand the single sample testing protocol, we explored multiple extraction-free pooled saliva testing workflows prior to testing with the SalivaDirect assay. A pool size of five, with or without heat inactivation at 65°C for 15 minutes prior to testing resulted in a positive agreement of 98% and 89%, respectively, and an increased Ct value shift of 1.37 and 1.99 as compared to individual testing of the positive clinical saliva specimens. Applying this shift in Ct value to 316 individual, sequentially collected, SARS-CoV-2 positive saliva specimen results reported from six clinical laboratories using the original SalivaDirect assay, 100% of the samples would have been detected (Ct value &gt;45) had they been tested in the 1:5 pool strategy. The availability of multiple pooled testing workflows for laboratories can increase test turnaround time, permitting results in a more actionable time frame while minimizing testing costs and changes to laboratory operational flow.
MDM2 overexpression is associated with short survival in adults with medulloblastoma
Authors: Maria Teresa Giordana, Debora Duó, Sabrina Gasverde, Elisa Trevisan, Andrea Boghi, Isabella Morra, Luca Pradotto, Alessandro Mauro, Adriano Chió
Journal: Neuro-Oncology (2002)

A P R I L
Menstrual history as a determinant of current bone density in young athletes
Authors: B. L. Drinkwater
Journal: JAMA (1990)

The relationship of prior menstrual irregularities and current menstrual status to the bone density of 97 young athletes was determined at seven sites using single- and dual-photon absorptiometry. Menstrual patterns were ranked on a scale of 1 to 9 in terms of their potential adverse affect on bone. Only vertebral density was significantly related to menstrual patterns (<i>r</i>= —.43). Women who had always had regular cycles had higher lumbar densities (1.27 g/cm<sup>2</sup>) than those with a history of oligomenorrhea/amenorrhea interspersed with regular periods (1.18 g/cm<sup>2</sup>). The lumbar density of both groups exceeded that of women who had never had regular cycles (1.05 g/cm<sup>2</sup>). Body weight became more important as a predictor variable as the severity of menstrual irregularities increased. The combination of menstrual pattern and body weight predicted 43% of the total variation in lumbar density. These data suggest that extended periods of oligomenorrhea/amenorrhea may have a residual effect on lumbar bone density. (<i>JAMA</i>. 1990;263:545-548)
The prospective payment system: a civic good, not a civil war
Authors: F. Haruda
Journal: JAMA (1991)

<h3>In Reply.—</h3> In our comparison of measures of excess chronic disease mortality in the United States, we used age-specific mortality rates for each state (including the 50 states and Washington, DC) in 1986 (calculated from deaths and intercensal population estimates, both for 1986). We age-standardized rates to the 1980 US population because these data are widely available. In an earlier publication (<i>MMWR</i>. 1989;39:17-20), we computed the rates in each state in the same way, but age-standardized them to the 1986 US population. In changing the standard population, the ranking was unchanged for 33 states, changed one place for 12 states, and changed two places for six states. In changing from the 1980 to the 1986 standard, the 10 states with the highest rates remained the top 10, while one state was added (Kansas) and one was dropped (Colorado) from the lowest 10. As Dr Richter suggests, changes in rank reflect
Premedical Education
Authors: Martha L. Elks
Journal: JAMA (1981)

<h3>To the Editor.—</h3> Recent articles (243:2506, 1980;243:2518, 1980) addressed the choice of the college major of medical students. While these articles cited the prevalence of science majors, they did not address the reasons for the choice of this major. At many institutions, one may major in chemistry by taking only three to four more courses in chemistry beyond the standard medical school requirements. Also, these courses are usually exact and quantitative, with excellent grades dependent on controllable aspects such as memorization and sweat—rather than the independent thought or adherence to the professor's ideals necessary for excellent grades in the humanities. Thus, it may be that chemistry is often chosen as a major because it is easier than a philosophy or history major. Additionally, it should not be surprising that those interested in medicine are also interested in the physiology, anatomy, and other courses of a major in biology or
PTH-050 PEXACT®: analysis of 319 procedures performed at the Digestive Diseases Unit, University Hospital Aintree
Authors: S Ahmed, K Bowering, N Polavarapu, R Nicholson, P Thomas, R Sturgess
Journal: Gut (2010)

<h3>Introduction</h3> Patients with head and neck cancers can require nutritional support during and after treatment of their cancers. This is commonly done via a gastrostomy. The original “pull though” PEG has an increased risk of tumour implantation at the PEG site. We therefore changed our practice to direct puncture gastrostomy insertion in 2004, using the PEXACT® (fresenius) gastrostomy system, for all head and neck cancer patients. We have previously reported our first year experience of 89 cases. We report our practice since then. <h3>Methods</h3> All PEXACTS® performed in the unit between November 2005 and November 2009 were identified, using our endoscopy reporting system and from referral register. Further information regarding each patient (readmissions, complications and mortality) was obtained from the hospital patient administration system. <h3>Results</h3> According to the data available to date, 319 PEXACT® insertions were identified in 317 patients. 79% of patients were male (n=251). Average age was 58 years (18–85 years). 99% (n=316) patients had a head and neck cancer as the indication. Insertion was successful in 99% (n=316) and unsuccessful in 3(0.9%) patients: 2 cases due to poor access and 1 case due to gastric intramucosal haematoma. All patients had prophylactic antibiotics on the ward prior to the procedure. In total six patients died within 30 days (1.9%), 1 within 7 days (0.3%). Of the 30-day deaths, 3 were due to disease progression, one neutropenic sepsis following chemotherapy and two had no record of the cause of death available. Two patients had major procedure related complications (0.6%). On both occasions complications was identified immediately. One of the patients had splenic injury during the procedure and required emergency surgery, the second patient had intra-abdominal haematoma due to laceration of gastric wall which was managed conservatively and resolved spontaneously with good outcome. Ten (3.1%) patients had unplanned admissions within 30 days of their procedure. Four patients were admitted within 7 days (1.3%). Reasons for readmission included displaced or blocked gastrostomy tube n=2 (0.6%), disease progression n=2 (0.6%), gastrostomy site infection n=3 (0.9%) and 1 (0.3%) patient developed an aspiration pneumonia secondary to alcohol excess. There have been no cases of tumour implantation to date. Late displacement of the gastrostomy tube (&gt;30 days after insertion) was common (6.6%). Most were replaced at the bedside. <h3>Conclusion</h3> PEXACT® is a safe and reliable method of gastrostomy tube placement. Overall, our complication rate has fallen, with only two major procedure related complications during this period. There have been no procedure related deaths. There have been no cases of tumour implantation.
Nothing to Be Frightened Of
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Posttransfusion Hepatitis After Open-Heart Operations
Authors: John H. Walsh
Journal: JAMA (1970)

The incidence of icteric and anicteric hepatitis was determined prospectively in 110 patients undergoing open-heart operations in which cardiopulmonary bypass was used. Patients were supplied with blood from two commercial blood banks (82 patients), or from local volunteer donors (28 patients). Serial determinations of serum transaminase levels were obtained for six months following operation. Hepatitis developed in 51% (42) of the recipients of commercial blood, but the disease did not occur in any patient who received blood from volunteer donors. The hepatitis carrier rate for commercial blood donors was 6.3%, but, for volunteer donors, was less than 0.6%. This difference in carrier rates probably reflects differences in the donor populations.
Controlled prescribing.
Authors: C Howlett
Journal: BMJ (1978)

The efficacy of adjuvant photodynamic therapy (PDT) using the new photosensitizer, talaporfin sodium (TPS), was assessed in 7 patients with bile duct carcinoma (BDC). The 664-nm semiconductor laser (100 J/cm<sup>2</sup>) was applied through endoscopy to the tumor lesion within 6 h after injection of TPS. Cases included three non-resectable and 4 resected BDC with remnant cancer cells at the bile duct stump. Radiated lesions exhibited mild inflammatory responses. Locally advanced tumor occluding bile duct was relieved by PDT and patency was maintained for 16 months. Two patients developed mild photodermatitis but no severe morbidity. One patient died of other disease, and two patients died of liver metastasis within 6 months, but local recurrence was not observed. Three patients maintained cancer-free survival for 6-13 months. One patient survived with good status for 24 months. Adjuvant TPS-PDT is a safe and useful treatment for local control of BDC. Compared to the conventional PDT, the patient9s quality of life is remarkably improved.
Kystoskopischer Atlas. Ein Grundriss für Studierende und Aerzte.
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hay Fever.
Authors: S. S. Bishop
Journal: JAMA (1894)

Chicago, March 3,1894. <h3>To the Editor:</h3> In reply to the question of Dr. F. C. Ewing in theJournalof this date a list of the best hay fever resorts can be obtained by writing to one of the officers of the United States Hay Fever Association, for their last manual —for 1893. Their addresses are: Hon. Frank B. Fay, Chelsea, Mass., President; Rev. John Peacock, D.D., Holmesburg, Pa., Secretary. Yours truly,
Correction: Antenatal screening for Down's syndrome
Authors: S Obaro
Journal: BMJ (1993)

increased intracranial pressure is invariably present in acute meningeal inflammation' and lumbar puncture should always be undertaken with caution.Theoretically, the risk of precipitating sudden intracranial pressure loss may be reduced by minimal physical restraint and avoiding neck flexion; use of a small bore needle; obtaining a minimal volume of cerebrospinal fluid (less than 1 ml); and retracting skin from the puncture site before removing the needle and thereafter generously applying collodion to pre- vent leakage of cerebrospinal fluid after puncture.