tbuckley/cabot-search huggingface dataset:
Authors' reply
Authors: M. A Schuster
Journal: BMJ (2008)

<h3>Background</h3> Migrant populations are particularly at risk of not receiving the care for mental ill-health that they require for a range of reasons, including language and other barriers to health service access. This record linkage study compares, for migrant and settled communities, the likelihood that a person in Northern Ireland with poor mental health will receive psychotropic medication. <h3>Methods</h3> A cohort of 78&nbsp;267 people aged 16–64 years (including 1736 migrants) who reported chronic poor mental health in the 2011 Census records was followed for 15&nbsp;months by linkage to a centralised prescribing data set to determine the rates of pharmacological treatment. Logistic regression analyses quantified the relationship between psychotropic medication uptake and migrant status, while accounting for relevant demographic and socioeconomic factors. <h3>Results</h3> Overall, 67% of the migrants with chronic poor mental health received at least one psychotropic medication during the study period, compared to 86% for the settled population; this equates to an OR of 0.32 (95% CI 0.29 to 0.36) in the fully adjusted models. Adjustment for English proficiency did not significantly alter these models. There was also considerable variation between individual migrant groups. <h3>Conclusion</h3> Although this study suggests substantial unmet need for treatment of poor mental health among the migrant population of Northern Ireland, further qualitative studies are required to better understand how different migrant groups respond to mental ill-health.
Tenth Scientific Report on the Investigations of the Imperial Cancer Research Fund. Under the Direction of the Royal College of Physicians of London and the Royal College of Surgeons of England. Boards.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Transmission of Infection by Endoscopy
Authors: David H. Spach
Journal: Annals of Internal Medicine (1993)

Letters1 September 1993Transmission of Infection by EndoscopyDavid H. Spach, MD, Fred E. Silverstein, MD, and Walter E. Stamm, MDDavid H. Spach, MDSearch for more papers by this author, Fred E. Silverstein, MDSearch for more papers by this author, and Walter E. Stamm, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-5-199309010-00035 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Dr. Markovitz's report was reviewed, but our article only included infections transmitted by flexible, not rigid, fiberoptic bronchoscopes.We disagree with Drs. Benjamin and Bond that universal use of effective disinfection exists and believe that recognized and reported cases probably represent a minority of all infections transmitted by endoscopy. Seven studies published since 1988 show that major problems still exist regarding compliance with accepted cleaning and disinfection guidelines. In a recent collaborative effort (which included the Food and Drug Administration), investigators found numerous fundamental errors in cleaning and disinfection procedures [1]. Moreover, among cultures taken from endoscopes deemed ...References1. Kaczmarek RG, Moore RM Jr, McCrohan J, Goldman DA, Reynolds C, Caquelin C, et al. Multi-state investigation of the actual disinfection/sterilization of endoscopes in health care facilities. Am J Med. 1992; 92:257-61. Google Scholar2. Gorse GJ, Messner RL. Infection control practices in gastrointestinal endoscopy in the United States: a national survey. Infect Control Hosp Epidemiol. 1991; 12:289-96. Google Scholar3. Katner HP, Buckley RL, Smith MU, Henderson AM. Endoscopic cleaning and disinfection procedures for preventing iatrogenic spread of human immunodeficiency virus. J Fam Pract. 1988; 27:271-6. Google Scholar4. United States General Accounting Office. Disinfectants: EPA lacks assurance they work. Gaithersburg, Maryland: United States General Accounting Office; 1990:1-68; publication no. GAO/RCED-90-139. Google Scholar5. Fraser V, O'Rourke S, Jones M, Murray P, Clouse RE, Klasner J, et al. Gastrointestinal endoscope disinfection: a prospective randomized trial comparing automated and manual disinfection (Abstract 12). Gastrointest Endosc. 1992; 38:277. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1993Volume 119, Issue 5Page: 440-441KeywordsBacteriaDisinfectionEndoscopyFood and Drug AdministrationHIVMotivation ePublished: 15 August 2000 Issue Published: 1 September 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Books Received
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Deutsche Medizinische Wochenschrift, Stuttgart
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MOLLUSCUM CONTAGIOSUM.
Authors: WM. FRICK
Journal: JAMA (1899)

The titles ''molluscum contagiosum,'' ''molluscum verrucosum,'' ''molluscum epitheliale,'' ''epithelioma contagiosum'' and "acne varioliform,'' have all been used to designate the same disease. Bateman, in his description of it, in 1817, used the first of these titles, and after long years of discussion and application of other titles, we seem to be coming back to a general use of the same. Especially do I think this is the better name to use since the work of Dr. Henry W. Stelwagon in proof of the contagiousness of the disease. In a paper read at the eighteenth annual meeting of the American Dermatological Association,<sup>1</sup>he cites about 375 cases reported by thirty-nine different authors showing contagiousness. These cases reported by so many observers were scattered through seventy-seven years of time—from Bateman's cases in 1817 to Brocq's accidental inoculation of himself in 1894. While, from this weight of evidence, we must concede the
Masthead: (Adv. Healthcare Mater. 21/2016)
Journal: Advanced Healthcare Materials (2016)

Citizenship: Wiley's Corporate Citizenship initiative seeks to address the environmental, social, economic, and ethical challenges faced in our business and which are important to our diverse stakeholder groups.Since launching the initiative, we have focused on sharing our content with those in need, enhancing community philanthropy, reducing our carbon impact, creating global guidelines and best practices for paper use, establishing a vendor code of ethics, and engaging our colleagues and other stakeholders in our efforts.
A novel microsimulation model of chronic hepatitis B (HBV): validation of HBV viral dynamics and cumulative incidence of hepatocellular carcinoma
Authors: Amir Mohareb, Arthur Kim, Anders Boyd, Farzad Noubary, Menan Gérard Kouamé, Serge Paul Eholié, Kenneth Freedberg, Rochelle Walensky, Emily Hyle
Journal: Journal of Hepatology (2020)
Norepinephrine-secreting tumor of the organ of Zuckerkandl. Response to propranolol alone
Authors: H. H. Newsome
Journal: JAMA (1979)

A 24-year-old man with diagnosed pheochromocytoma of the organ of Zukerkandl, was successfully treated with propranolol hydrochloride to lower his blood pressure. In view of the positive response to propranolol, the patient was expected to have an epinephrine-secreting tumor. However, measurement of catecholamines showed that preoperative peripheral blood, vena caval samples from the tumor, intraoperative peripheral samples, and the tumor itself contained almost exclusively norephinephrine. A response of blood pressure to propranolol in a hypertensive patient does not rule out the possibility of a pheochromocytoma, even one with the usual norephinephrine predominance.
RIO DE JANEIRO
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 1145: Biomarker-driven molecular imaging of prostate cancer using the PEG10 promoter
Authors: Mariya Shapovalova
Journal: Cancer Research (2019)

Abstract The retrotransposon-derived paternally expressed gene 10 (PEG10) protein is ordinarily expressed at high levels in the placenta. The over-expression of PEG10 has been documented in a number of malignancies including hepatocellular carcinoma and leukemia. Recently, it was discovered that PEG10 isoforms promoted the progression of prostate adenocarcinoma to a highly lethal non-androgen receptor (AR) driven subtype called aggressive variant prostate cancer (AVPC). In this study, we found that PEG10 was also expressed in castration-resistant PCa possessing constitutively active AR-splice variants in addition to AR-negative AVPC. We subsequently developed a molecular genetic imaging strategy for the non-invasive imaging of PCa by utilizing the cancer specificity of the PEG10 promoter to drive the expression of reporter genes. The transcriptional output of the PEG10 promoter was enhanced to enable high expression of reporter genes by multiple imaging modalities and immunoassay. By using this PEG10 promoter upstream of a reporter gene in a plasmid, we were able to detect PCa by fluorescence and positron emission tomography (PET) imaging after systemic administration of the plasmid in mice. This method also allowed for the detection of PCa by an immunoassay of mouse urine. Our study demonstrates a pre-clinical proof-of-concept that the PEG10 promoter is a powerful and specific tool that can be utilized for non-invasive detection of highly lethal PCa subtypes. This biomarker imaging technology has the potential to improve detection and can be further modified for therapeutic applications. Citation Format: Mariya Shapovalova. Biomarker-driven molecular imaging of prostate cancer using the PEG10 promoter [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1145.
Survival in Hodgkin's disease.
Journal: BMJ (1965)

BRNmHMEDICAL JOURNAI reduced to 1% with adequate precaution.With the increasing use of colour developers, especially among amateur photo- graphers who may be unaware of the hazards, we can expect a steady rise in the number of persons developing either the eczematous or the lichenoid type of eruption, and it would be well to be on the look-out for them.
Risk stratification in unstable angina. Prospective validation of the Braunwald classification
Authors: J. E. Calvin
Journal: JAMA (1995)

<h3>Objectives.</h3> —To validate the Braunwald classification of unstable angina as a predictor of in-hospital cardiac complications; to determine which factors of the Braunwald classification contributed significantly to this prediction; and to devise a method of combining these predictive factors into an overall odds ratio for complications. <h3>Design.</h3> —A validation cohort of consecutive patients followed prospectively for in-hospital cardiac complications including myocardial infarction and death. <h3>Setting.</h3> —A community-based academic medical center. <h3>Patients.</h3> —A total of 393 patients admitted consecutively to the coronary care and intermediate care units with unstable angina. <h3>Main Outcome Measures.</h3> —Major cardiac complications including death, myocardial infarction, congestive heart failure, cardiogenic shock, and severe ventricular dysrhythmias. <h3>Results.</h3> —Multiple logistic regression analysis identified four clinical factors used in the Braunwald classification that predicted the in-hospital occurrence of major cardiac complications: (1) myocardial infarction within less than 14 days (odds ratio [OR], 5.72; 95% confidence interval [CI], 1.92 to 16.97); (2) need for intravenous nitroglycerin (OR, 2.33; 95% CI, 1.31 to 4.17); (3) lack of β-blocker or calcium channel blocker prior to admission (OR, 3.83; 95% CI, 1.55 to 9.42); and (4) baseline ST depression (OR, 2.81; 95% CI, 1.45 to 5.47). Two other clinical factors, diabetes and age, were also significant predictors. Validation of this model using parametric and nonparametric bootstrap techniques revealed excellent agreement between the CIs for adjusted ORs derived from the multiple logistic regression and those derived from the bootstrap. <h3>Conclusions.</h3> —The classification of unstable angina proposed by Braunwald includes four factors that predict risk of major in-hospital cardiac complications. Specific factors used in this classification can be combined with diabetes and age to better stratify risk of major cardiac complications in this disorder using a simpler model. (<i>JAMA</i>. 1995;273:136-141)
Abstract 1789: The importance of the phosphatase PRL family sub-cellular localization during the cellular cycle
Authors: Anna K. O'Leary, Jessica Blackburn
Journal: Cancer Research (2019)

Abstract Acute lymphoblastic leukemia (ALL) is one of the most prevalent cancers diagnosed in adolescents. The survival rate for ALL is good during the initial diagnosis but is much less optimistic for patients who have relapsed ALL, due to limited treatment options. Additionally, the high dose cytotoxic chemotherapies given to ALL patients have long term adverse consequences. New and less toxic targeted therapies are needed for the treatment of ALL. We previously performed a large scale transplantation screen in zebrafish to identify genes associated with high relapse potential in ALL, and a top hit from this screen was the protein tyrosine phosphatase 4A3, PTP4A3 or PRL3. PRL3 overexpression in zebrafish enhances ALL progression and penetrance, and small molecule targeting of PRL3 in human cells rapidly induces apoptosis. The mechanisms through which PRL3 drive ALL progression and survival are unknown. PRL3 has a predicted nuclear localization site as well as a predicted prenylation motif, causing its localization to the plasma membrane. My preliminary data suggest that PRL3 shifts its localization between the plasma membrane and nucleus during the cell cycle. I am currently examining the localization of PRL3 and other PRL family members during different phases of the cell cycle and identifying signaling pathways that they may be involved with at these distinct sites to promote ALL progression, using CLIP-tag and SNAP-tag technologies that will allow me to image directly PRL localization in vitro. Biotin ligase approaches (Turbo-ID) will be used to determine the substrates of PRL activity and PRL interacting partners at these distinct locations. My project will provide scientific data that supports our hypothesis that PRL3 can transition between the membrane and nucleus, and plays a role in cell cycle. Identification of substrates of PRL3 that promote ALL progression may provide novel drug targets for this disease. Citation Format: Anna K. O'Leary, Jessica Blackburn. The importance of the phosphatase PRL family sub-cellular localization during the cellular cycle [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1789.
Impaired Coronary Endothelium-Dependent Vasodilation Is Associated With Microalbuminuria in Patients With Type 2 Diabetes and Angiographically Normal Coronary Arteries
Authors: E. Cosson
Journal: Diabetes Care (2006)

OBJECTIVE—Microalbuminuria and impaired endothelium-dependent vasodilation are both predictors for cardiac events in patients with type 2 diabetes. The aim of the study was to evaluate whether microalbuminuria correlated with coronary endothelium–dependent vasodilation.
Budget Cuts Put West Nile Virus Surveillance in Jeopardy
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Rapid formation of donor cell microchimerism following intrathymic inoculation of splenocytes in transiently lymphocyte-depleted rats . Departments of Microbiology and Immunology, *Medicine and *Molecular Genetics, and Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, NY
Journal: Hepatology (1995)

Background: Although non-A, non-B (NANB) viral hepatitis has been implicated as an etiology of fulminant hepatitis, hepatitis C virus (HCV) has not been shown to result in acute hepatic failure and hepatitis E virus (HEV) has predominantly been associated with fulminant hepatitis among pregnant women. Methods: Using polymerase chain reaction to detect HCV and HEV genomes, four-antigen radioimmunoblot assay (4-RIBA) to measure anti-HCV antibodies, and enzyme-linked immunosorbent assay (ELISA) to detect anti-HEV immunoglobulin M (IgM) antibodies, 17 patients with sporadic fulminant or subfulminant hepatitis of presumed NANB viral etiology were studied. Results: The diagnosis of acute NANB viral hepatitis was made based on clinical information, serological tests, biochemical profiles, and pathological features. All 17 patients were negative for anti-HEV IgM antibodies and HEV RNA in either serum and/or liver. HCV RNAs were detected in 2 patients although anti-HCV antibodies were negative in all of them. Conclusions: It is shown that HCV is infrequently associated with and HEV is not an identifiable cause of presumed NANB fulminant or subfulminant hepatitis in this patient population. Although further studies will be required for identification of the causative agent, it is possible that another agent is responsible for the occurrence of sporadic NANB fulminant or subfulminant hepatitis.