tbuckley/cabot-search huggingface dataset:
Intellectual Development and the Erect Posture.
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fibrinolytic Activity, Obesity, and Coronary Heart Disease
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Switch to soy protein for boring but healthful diet
Authors: W. A. Check
Journal: JAMA (1982)

Physicians attempting to alter the blood lipid levels of their patients might look to a new form of control: increasing the proportion of plant protein in the diet. Two reports at the recent meeting of the American Institute of Nutrition in New Orleans showed that substituting plant protein for animal protein in the diets of healthy, normal volunteers had beneficial effects on blood lipid levels in short-term trials, even though the lipid component of the diet was not altered. The different degrees of change seen in the two studies may reflect the different proportions of plant protein in the respective diets. Those of us raised with the contemporary emphasis on reducing dietary fats and cholesterol might be surprised to learn that the first explanation of atherogenesis focused primarily on protein. In 1909, the Russian physician and physiologist A. Ignatowski postulated that the clearest explanation for the high incidence of heart
Twelve versus 36 months of adjuvant imatinib (IM) as treatment of operable GIST with a high risk of recurrence: Final results of a randomized trial (SSGXVIII/AIO).
Authors: H. Joensuu, M. Eriksson, J. Hatrmann, K. Sundby Hall, J. Schutte, A. Reichardt, M. Schlemmer, E. Wardelmann, G. Ramadori, S. Al-Batran, B. E. Nilsson, O. Monge, R. Kallio, M. Sarlomo-Rikala, P. Bono, M. Leinonen, P. Hohenberger, T. Alvegard, P. Reichardt
Journal: Journal of Clinical Oncology (2011)

LBA1 Background: Adjuvant IM administered for 12 months (mos) after surgery improves recurrence-free survival (RFS) of patients (pts) diagnosed with operable GIST. We compared 12 vs 36 mos of adjuvant IM as treatment of pts with a high risk for GIST recurrence after surgery. Methods: Pts with histologically diagnosed KIT-positive GIST were entered to this prospective, open-label, multicenter, randomized Phase III study (identifier NCT00116935 ). The risk of recurrence was estimated according to the modified Consensus Criteria. The primary objective was RFS. The secondary objectives included survival (OS) and treatment safety. The key exclusion criteria were ECOG PS &gt;2, metastatic or inoperable GIST, and &gt;12 wks from surgery to the study entry. IM was administered orally 400 mg/d. The sample size (n =200 in each group to obtain ≥110 events) was estimated by simulating log-rank tests assuming an overall hazard ratio (HR) of 0.44, a 20% drop-out rate, 2-sided type-I error rate of .05 and power 0.80. Analysis was based on the intention-to-treat population (ITT). Tumor histology was centrally reviewed. Results: 400 pts were entered to the study from Feb 2004 to Sep 2008. Three pts were excluded due to lack of consent from the ITT, which includes 15 pts who did not have GIST at a central review. The median FU time was 54 mos. RFS was longer in the 36-mo group compared to the 12-mo group (HR 0.46, 95% CI 0.32-0.65; p &lt;.0001; 5-y RFS 65.6% vs 47.9%, respectively). Pts assigned to 36-mo of IM had longer OS (HR 0.45, 0.22-0.89; p =.019; 5-y OS 92.0% vs 81.7%). IM was generally well tolerated. The proportion of pts who discontinued IM during the assigned treatment period for reasons other than GIST recurrence was 25.8% in the 36-mo group and 12.6% in the 12-mo group. Exploratory efficacy subgroup analyses including KIT and PDGFRA mutation analysis data from 366 tumors will be presented. Conclusions: IM administered for 36 mos improves RFS and OS compared to 12 mos of administration as adjuvant treatment of GIST pts who have a high estimated risk of recurrence after surgery.
Special Correspondence
Journal: BMJ (1912)

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Prenatal care and HIV screening
Authors: A. M. Kaunitz
Journal: JAMA (1987)

<h3>In Reply.—</h3> Dr Kaunitz et al report very valuable information concerning screening for HIV antibody in a prenatal clinic in Jacksonville, Fla. It is of interest to note the remarkably similar results of Del Tempelis et al,<sup>1</sup>who reported that 5.3 per 1000 women applying for a marriage license and 6.7 per 1000 women attending a sexually transmitted disease clinic in Alameda County in the San Francisco Bay area were positive for HIV antibody. It is not clear whether these rates of positive antibody are characteristic of all United States cities or only of these areas. These data, however, are striking enough to argue strongly for counseling and screening for all sexually active women of childbearing age. I agree with the authors that expanding screening to the family planning setting is a more effective way to prevent perinatal HIV transmission. Although identifying women with HIV infection and counseling them
Spontaneous aortosigmoid fistula
Authors: K. R. Reddy
Journal: JAMA (1982)

SPONTANEOUS rupture of an infrarenal abdominal aortic aneurysm into retroperitoneum or peritoneal cavity is a catastrophic event. Erosion into adjacent duodenum or esophagus is even more lethal. There have even been rare reports of spontaneous aneurysmal rupture into inferior vena cava and fascia. The only hope for survival in any of these cases is high awareness and early recognition so that timely operative intervention can be undertaken.<sup>1</sup> Although rupture of aortic prosthetic grafts into small and large intestine<sup>2</sup>has been reported, we have now seen a case of spontaneous aortosigmoid fistula. <h3>Report of a Case</h3> A 79-year-old woman with a three-day history of dyspnea, abdominal pain, and painful swelling of her left thigh was admitted with congestive heart failure. Medical history included poorly controlled hypertension. On physical examination her temperature was 37.8 °C; BP, 150/90 mm Hg; pulse rate, 120 beats per minute; and respirations, 30/min. She had
Indian Summer
Authors: Diana Pi
Journal: Annals of Internal Medicine (2013)

On Being a Doctor5 March 2013Indian SummerDiana Pi, MDDiana Pi, MDFrom Westlake, Ohio.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-158-5-201303050-00012 Audio Reading - “Indian Summer” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Indian Summer," by D. Pi. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail I was on my way to a local college for a premed pep talk. To avoid wrinkling the back of my shirt, I was driving hunched forward—and barefoot. I liked driving barefoot; I'd walk everywhere barefoot, if I could. I glanced resignedly at my black leather pumps sitting on the passenger seat, prim and unperturbed. Usually, I quite enjoyed these outside talks, but today, what had promised to be a relaxed afternoon diversion couldn't have happened at a worse time.As I wended my way to this sleepy college town, I tried to remember what he, the college kid who ... Author, Article, and Disclosure InformationAffiliations: From Westlake, Ohio.Corresponding Author: Diana Pi, MD, 25739 Briarwood Court, Westlake, OH 44145; e-mail, diana.pi.[email protected]com. PreviousarticleNextarticle Advertisement Audio Reading - “Indian Summer” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Indian Summer," by D. Pi. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetailsSee AlsoOn Being a Doctor: Leaving Is Not the Answer Maria Maldonado Metrics Cited byOn Being a Doctor: Leaving Is Not the AnswerMaria Maldonado, MD 5 March 2013Volume 158, Issue 5_Part_1Page: 355-356KeywordsChartsElectrode recordingEmotionsForecastingHand strengthLibrariesRunning ePublished: 5 March 2013 Issue Published: 5 March 2013 Copyright & PermissionsCopyright © 2013 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Immunohistochemical localization of an opiate peptide
Authors: J. H. Neale
Journal: JAMA (1980)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effects of Chronic Excess Salt Ingestion: Role of Genetic Factors in Both DOCA-Salt and Renal Hypertension
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
<i>Circulation:</i> Clinical Summaries
Journal: Circulation (2010)

Therapy Attenuates Ischemia-Induced Heart Failure in MiceHeart failure continues to be a major health problem as evidenced by a rise in the number of hospitalizations for heart failure, the number of deaths attributed to heart failure, and the ever-increasing costs associated with care.Therapeutic strategies designed to coincide with the standard means of care are, therefore, needed to combat the development and progression of heart failure.Hydrogen sulfide (H 2 S) is an endogenous gaseous signaling molecule with a diverse physiological profile that has recently been shown to be cardioprotective in various models of cardiac injury.In the present study, we found that either the modulation of endogenous H 2 S production or direct pharmacologic H 2 S administration significantly reduced mortality and attenuated the severity of ischemia-induced heart failure in mice.Importantly, the present study demonstrates that although a single administration of H 2 S at the time of reperfusion is beneficial in attenuating infarct size, this alone is not sufficient to improve cardiac function significantly.On the other hand, daily H 2 S therapy for the first 7 days of reperfusion or increased endogenous H 2 S production provided significant improvements in cardiac function, suggesting that multiple therapeutic interventions are paramount for improvements in outcome.Together, these findings further support the emerging concept that H 2 S therapy may be of clinical importance in the treatment of cardiovascular disease and may have a practical clinical use after myocardial infarction to reduce the morbidity and mortality associated with ischemia-induced heart failure.See p 11.
And now a Yugoslav JAMA
Authors: I. Thomas
Journal: JAMA (1985)

In 1918, Yugoslavia emerged as a new nation, patched together at the end of World War I from the defeated Austrian-Hungarian and Ottoman Empires plus the kingdoms of Montenegro and Serbia. For some years Yugoslavia was an independent kingdom. After World War II it became a republic. Now the official name is the Socialist Federal Republic of Yugoslavia. Throughout its history turbulence has often been the rule and not the exception. Yugoslavia controls important land routes from central and western Europe to the Aegean Sea and Turkish Straits. Since the Middle Ages and the times of the Byzantine Empire, the area has served as a natural bridge between East and West, thus being a vulnerable prize in geopolitical conflicts. Today, the economic problems of Yugoslavia are similar to those of many countries. It is encountering a high rate of inflation and substantial unemployment and is weathering balance of payment and
Leads from the MMWR. Rubella and congenital rubella--United States, 1980-1983
Journal: JAMA (1983)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AUTHORS' REPLY
Authors: M. Luengo, C. Picado
Journal: Thorax (1992)

absorptiometry (DEXA) in corticosteroid associated osteoporosis.We reported to the summer 1991 meeting ofthe British Thoracic Society' our experience of 19 patients (13 female) with corticosteroid dependent asthma.Twelve of these patients had sustained at least one vertebral compression fracture.The mean corticosteroid dose and treatment duration for this fracture group was 10-1 mg prednisolone/day for 13-1 years and 13-9 mg prednisolone/day for 9-6 years in those patients without fracture (NS).The mean L2-L4 density was significantly lower in those patients with fractures (0-797 g/cm' versus 1-143 g/cm', p < 0-0001).The mean neck of femur density was also significantly lower in those patients with fractures (0-718 g/cm2 versus 0-901 g/cm2, p < 0 005).The study by Dr Luengo and colleagues used dual photon densitometry, which is known to be a less precise measure than DEXA,' and this may explain why in their study, though spinal density was higher in asthmatic patients without fractures, the difference was not statistically significant.It would appear therefore that a single measure of L2-L4 density by DEXA is a useful screening test for corticosteroid associated osteoporosis.Finally, in their discussion the authors ignore the effect of the menopause on the changes described.There is significant evidence that premenopausal women, who (though it is not stated) probably make up most of "group 1," are protected from corticosteroid associated osteoporosis, presumably by the effects of oestrogen.
Medical Department of the University of Michigan.—
Journal: JAMA (1892)

The first ward of the new hospital of the medical department of Michigan University, is now completed and will be formally opened by the Governor of the State, Jan. 20th. On this occasion an address, " The Hospital: an element and exponent of Medical Education," will be given by Albert L. Gihon, A.M., M.D., Medical Director, United States Navy. The hospital was designed by Chamberlain and Austin of Boston, and E. W. Arnold of Detroit, and is supplied with modern hospital appliances. The ward just completed contains clinical amphitheatre, consultation rooms, offices and accommodations for eighty patients. It has cost about eighty thousand dollars. The plan provides for three additional wards, the erection of one of which will be begun during the present year.
Electrosurgical Devices
Authors: Saul Aronow
Journal: JAMA (1976)

<h3>To the Editor.—</h3> May I offer some comment to clarify the answer to a question on the safety of electrosurgical apparatus in a recent issue ofThe Journal?<sup>1</sup> The newer solid-state devices are smaller, technologically modern, usually less powerful, but not necessarily<i>safer</i>than the older spark-gap machine. They may be more effective for some purposes but are less so for others. There are hazards associated with the use of such intentionally destructive high-power devices, but these hazards and complications are largely attributable to lack of knowledge or inadequate training of medical personnel operating them and not to faults of the apparatus. The Rogers subcommittee report (94-853) of 858 deaths due to devices should be quoted with great caution. Before using it to imply that a particular device is potentially lethal, one should check that the report has any reference to such device. The Rogers report quotes 751 fatalities,
Glucose-induced β cell production of IL-1β contributes to glucotoxicity in human pancreatic islets
Authors: Kathrin Maedler, Pavel Sergeev, Frédéric Ris, José Oberholzer, Helen I. Joller-Jemelka, Giatgen A. Spinas, Nurit Kaiser, Philippe A. Halban, Marc Y. Donath
Journal: Journal of Clinical Investigation (2002)

In type 2 diabetes, chronic hyperglycemia is suggested to be detrimental to pancreatic beta cells, causing impaired insulin secretion. IL-1beta is a proinflammatory cytokine acting during the autoimmune process of type 1 diabetes. IL-1beta inhibits beta cell function and promotes Fas-triggered apoptosis in part by activating the transcription factor NF-kappaB. Recently, we have shown that increased glucose concentrations also induce Fas expression and beta cell apoptosis in human islets. The aim of the present study was to test the hypothesis that IL-1beta may mediate the deleterious effects of high glucose on human beta cells. In vitro exposure of islets from nondiabetic organ donors to high glucose levels resulted in increased production and release of IL-1beta, followed by NF-kappaB activation, Fas upregulation, DNA fragmentation, and impaired beta cell function. The IL-1 receptor antagonist protected cultured human islets from these deleterious effects. beta cells themselves were identified as the islet cellular source of glucose-induced IL-1beta. In vivo, IL-1beta-producing beta cells were observed in pancreatic sections of type 2 diabetic patients but not in nondiabetic control subjects. Similarly, IL-1beta was induced in beta cells of the gerbil Psammomys obesus during development of diabetes. Treatment of the animals with phlorizin normalized plasma glucose and prevented beta cell expression of IL-1beta. These findings implicate an inflammatory process in the pathogenesis of glucotoxicity in type 2 diabetes and identify the IL-1beta/NF-kappaB pathway as a target to preserve beta cell mass and function in this condition.
In This Issue of JAMA Internal Medicine
Journal: JAMA Internal Medicine (2013)

P olicy makers are increasingly interested in identifying waste in our health care system.Kale et al performed a comparative analysis using data from the 1999 and 2009 National Ambulatory Medical Care Survey and National Hospital Ambulatory Medical Care Survey to examine the performance of outpatient quality measures.They found that of 9 underuse measures, 6 improved, while of 11 overuse indicators, only 2 improved.The limited improvements in the overuse measures may reflect a national quality mission that is hampered by a lack of incentives and performance measures that support the reduction of inappropriate care.