tbuckley/cabot-search huggingface dataset:
Some Observations on the Deposition of Metastatic Carcinoma Within Cervical Lymph Nodes
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Crucial Antibody Response
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Discovery and Characterization of Cas9 Inhibitors Disseminated across Seven Bacterial Phyla
Authors: Ruben V. Uribe, Eric van der Helm, Maria-Anna Misiakou, Sang-Woo Lee, Stefan Kol, Morten O.A. Sommer
Journal: Cell Host & Microbe (2019)

(Cell Host & Microbe 25, 233–241.e1–e5; February 13, 2019) We the editors of Cell Host & Microbe have been informed by the Lead Contact and corresponding author, Dr. Morten O.A. Sommer, about new data that relate to Figure 2B in their original Uribe et al. paper. The original paper reported that AcrIIA8 directly binds to SpCas9 in addition to directly inhibiting SpCas9 activity in a DNA cleavage assay. In follow-up experiments, the direct binding of AcrIIA8 and SpCas9 could not be reproduced. Despite multiple attempts by both the authors and a group of collaborators, additional experiments with new batches of AcrIIA8 did not show direct binding to SpCas9. Using mass spectrometry, the identity of AcrIIA8 in all samples was confirmed. However, it was found that the original batch used for generating the data in Figure 2B was contaminated with AcrIIA9. Accordingly, the binding to SpCas9 that was originally attributed to AcrIIA8 actually resulted from contamination with AcrIIA9. Although the finding that AcrIIA8 binds to SpCas9 is no longer accurate, the anti-CRISPR activity of AcrIIA8 that was originally demonstrated in the in vitro cleavage assay has been confirmed using the new samples. With this note, we and the authors would like to alert the community and direct you to additional data related to Figure 2B, which have been deposited in Mendeley Data and can be accessed here. The remaining findings in the paper are unchanged, and these new data do not alter the main conclusions of the paper. Discovery and Characterization of Cas9 Inhibitors Disseminated across Seven Bacterial PhylaUribe et al.Cell Host & MicrobeFebruary 5, 2019In BriefUribe et al. developed a high-throughput approach to screen for type II-A CRISPR-Cas inhibitors in metagenomic libraries based on their functional activity rather than sequence homology or genetic context. This approach led to the discovery of four novel anti-CRISPR proteins, homologs of which are widely distributed across seven bacterial phyla. Full-Text PDF Open Archive
Intensive treatment of hyperglycemia improves endothelial dysfunction coupled with tumor necrosis factor-a in patients with non-insulin-dependent diabetes mellitus Satoshi Yasuda, Munetake Kanda, Yutaka Harano, Yoichi Goto, Masaaki Suzuki, Shunichi Miyazaki, Hiroshi Nonogi. National Cardiovascular Center, Suita, Osaka, Japan
Journal: Journal of the American College of Cardiology (2001)
Physical bases for mental illnesses.
Journal: BMJ (1973)

Physical Bases for Mental IllnessesFever is a word for a bodily response, a syndrome of signs and symptoms which is not a pathological entity, but may result from any one of many causes.Now everyone recognizes this, but in former centuries things were not so clear.Clinicians gradually learned to subdivide the syndrome into distinct clinical pictures-quartan fever, relapsing fever, periodic fever, trench fever, with differing settings, courses, and prognoses.Later, laboratory workers developed tests which showed that bacteria, protozoa, or viruses caused this or that fever, while allergies, neoplasms, or metalbolic dis- order were responsible in yet other cases.Delirium, a fluctua- ting state of disorientation, hallucinations, and rapid mood change sometimes formed a part of the fever syndrome.Such a mental disturbance was always regarded as physically based.Epilepsy, in its major form the falling sickness or sacred disease of old, has gone through a similar development as a name for a clinical syndrome.The syndrome has been widened to include petit mal and psychomotor forms and subdivided by clinicians, aided latterly by electroencephalographers.Again, laboratory workers have found many pos- sible causes-traumatic, neoplastic, metabolic, endocrino- logical, or drug-induced.The behavioural disturbances of postictal automatism have long been accepted as physically bap.ed.Presumably impairment of consciousness here, as in delirium, made it easy to believe.But the complex psycho- logical auras of some temporal-lobe epileptics are also accepted as organic in origin, even when they can be modi- fied by psychological intervention.1 2This century manic-depressive illness has been increasingly talked about, sometimes with a tendency to regard the words
Prognostic utility of comparative methods for assessment of ST-segment resolution after primary angioplasty for acute myocardial infarctionThe controlled abciximab and device investigation to lower late angioplasty complications (CADILLAC) trial
Authors: M MCLAUGHLIN, G STONE, E AYMONG, G GARDNER, R MEHRAN, A LANSKY, C GRINES, J TCHENG, D COX, T STUCKEY
Journal: Journal of the American College of Cardiology (2004)
Peripheral vascular symptoms as the initial manifestation of polycythemia vera
Authors: E. A. Edwards
Journal: JAMA (1970)

Peripheral vascular complaints first raised the question of polycythemia vera in 16 of 26 patients with this disease. Manifestations suggestive of polycythemia vera included red or cyanotic fingers or toes with or without burning pain, notably when pulses were palpable; occasional erythromelalgia; thrombophlebitis without other known cause; and the occurrence of coronary or cerebral ischemia at an early age. In six of the 16 patients, elevated platelet counts were found in the presence of normal venous hematocrit readings. Three of these patients had significant leukocytosis. In these patients, and in the others without organic arterial lesions, lowering of the hematocrit reading or platelet count or both proved beneficial and usually curative. Severe secondary polycythemia may at times produce symptoms similar to those of polycythemia vera. Surgeons and dermatologists have special opportunities to identify polycythemia vera among their patients.
Scottish Medical Journal, Glascow
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CD45: An Emerging Role as a Protein Tyrosine Phosphatase Required for Lymphocyte Activation and Development
Authors: I. S. Trowbridge
Journal: Annual Review of Immunology (1994)

CD45 is one of the most abundant leukocyte cell surface glycoproteins and is expressed exclusively upon cells of the hematopoietic system. Different isoforms of CD45 are generated by alternative splicing and are expressed in cell type-specific patterns on functional subpopulations of lymphocytes. In a major advance, CD45 was identified as one of the first members of a novel class of enzymes, the protein tyrosine phosphatases (PTPs). This serendipitous discovery linked CD45 to the process of reversible protein tyrosine phosphorylation, a key regulatory mechanism for controlling the growth and division of eukaryotic cells, and provided the impetus for most of the studies described in this review. CD45 is now established as a critical component of the signal transduction machinery of lymphocytes. In particular, evidence from genetic experiments indicates that CD45 plays a pivotal role in antigen-stimulated proliferation of T lymphocytes and in thymic development. Two members of the Src-family of protein tyrosine kinases (PTKs), the p56lck and p59fyn proteins, have been implicated as physiological substrates of CD45, providing an important clue to how the action of this leukocyte-specific PTP might influence signaling by the T cell antigen receptor. Structure-function analysis of CD45 and other PTPs has identified structural features of PTP catalytic domains required for enzymatic activity. However, despite intensive efforts, little is known about how the activity of CD45 is regulated. The external domain of CD45 does not appear to be absolutely required for signal transduction by the T cell receptor, and there is currently no evidence that ligand binding modulates CD45 activity. Analysis of CD45 isoform expression has revealed a hitherto unrecognized plasticity in isoform usage by T cells and other leukocytes, adding to the regulatory complexity of isoform expression.
Medium-term outcomes of hepatitis C virus-infected patients with a sustained viral response according to albumin-bilirubin grade
Authors: Akihiro Tamori, Naoshi Odagiri, Kanako Yoshida, Kohei Kotani, Hiroyuki Motoyama, Etsushi Kawamura, Hideki Fujii, Atsushi Hagihara, Sawako Uchida-Kobayashi, Masaru Enomoto, Norifumi Kawada
Journal: Journal of Hepatology (2020)
Predictive value of angiotensin II antagonists in renovascular hypertension
Authors: F. M. Fouad
Journal: JAMA (1983)

An angiotensin II antagonist, sarcosine-1, threonine-8 angiotensin II ([Sar<sup>1</sup>, Thr<sup>8</sup>] A II), was infused preoperatively in 14 patients with renal artery stenosis. Postoperative graft patency was documented by renal flow scan in 13 patients. One of these required antihypertensive therapy immediately after surgery, while the other 12 had a significant BP reduction in the first postoperative week (141 ±3.7 to 110±1.6 mm Hg). With longer follow-up, six patients remained normotensive (group 1), while the other six had "residual hypertension" (group 2). There was no significant difference between the two groups as regards age, preoperative BP level, plasma renin activity, blood volume, or response to [Sar<sup>1</sup>, Thr<sup>8</sup>] A II. In contrast, clinical signs were most helpful in predicting response to surgery. "Cured" patients had shorter duration of hypertension (less than one year) than patients with residual hypertension, and less impairment of renal excretory function; three patients in group 2 but none in group 1 had a history of malignant hypertension. The decision to operate remains a multifactorial evaluation and cannot be based on results of any single test alone. (<i>JAMA</i>1983;249:368-373)
INTERVERTEBRAL COMPRESSION OF THE SPINAL NERVES
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
DEATHS OF PHYSICIANS
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bureau of Legal Medicine and Legislation
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
NICKEL DERMATITIS.*
Authors: C. D. CALNAN
Journal: British Journal of Dermatology (1956)

Journal Article NICKEL DERMATITIS. Get access C. D. CALNAN, M.R.C.P. C. D. CALNAN, M.R.C.P. Senior Registrar, St. John's Hospital for Diseases of the Skin, London Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 68, Issue 7-8, 1 July 1956, Pages 229–236, https://doi.org/10.1111/j.1365-2133.1956.tb12808.x Published: 01 July 1956
More Women Treating Women
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reducing dietary intake of fat and cholesterol in children
Authors: T. B. Newman
Journal: JAMA (1995)

<h3>To the Editor.</h3> —We do not share the conclusion of the authors of the DISC study<sup>1</sup>that the "results indicate that children who<i>require</i>dietary change to lower their LDL-C levels may<i>safely</i>and<i>successfully</i>do so under supervision" (emphasis added). First, although the DISC found no adverse effects on growth, blood chemistry, or psychosocial health, it is not possible, with a 3-year study of only about 300 children per group, to say that the intervention is "safe." Although the diet clearly is not grossly hazardous, the real issue is whether there are uncommon, delayed, or subtle harmful effects that exceed the benefits. Given the small magnitude of the benefits, this question remains unanswered. Harms could be far greater than benefits and could still not be found in this study. Second, we disagree that the change of 0.08 mmol/L (3.23 mg/dL) in LDL-C achieved with intensive diet treatment (compared
Diagnostic and therapeutic technology assessment. Diaphanography (transillumination of the breast) for cancer screening
Journal: JAMA (1984)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Authors' response
Authors: Neal Navani, Onn Min Kon, Sam M Janes
Journal: Thorax (2011)

lung cancer according to the Liverpool Lung Project risk model, which will miss the opportunity to study the impact of screening in a low risk group population, and further the Liverpool Lung Project model may not take into account the separate risk factors working in different ethnic populations 4 thus making its prediction less reliable in the cosmopolitan UK population where according to the 2001 census >15% of the population is non-white British. 5 We hope that the investigators are open to our suggestions and will accept our ideas if they find some relevance in them.
FASHIONABLE APPENDICITIS.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cardiovascular Pharmacology
Authors: S. A REES
Journal: Cardiovascular Research (1992)

Cardiovascular Pharmacology Get access SIAN A REES SIAN A REES London, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 26, Issue 2, February 1992, Page 190, https://doi.org/10.1093/cvr/26.2.190 Published: 01 February 1992