tbuckley/cabot-search huggingface dataset:
Epidemiology of injuries in English professional rugby union: part 2 training Injuries
Authors: J H M Brooks, C W Fuller, S P T Kemp, D B Reddin
Journal: British Journal of Sports Medicine (2005)

To undertake a detailed epidemiological study of training injuries sustained by professional rugby union players in order to define their incidence, nature, severity, and causes.A two season prospective design was used to study training injuries associated with 502 rugby union players at 11 English Premiership clubs. Team clinicians reported all training injuries on a weekly basis and provided details of the location, diagnosis, severity, and mechanism of each injury. Training exposures for individual players were recorded on a weekly basis. Loss of time from training and match play was used as the definition of an injury.The overall incidence of injury was 2.0 per 1000 player-hours, and each injury resulted on average in 24 days lost time. Recurrences, which accounted for 19% of injuries, were more severe (35 days) than new injuries (21 days). Twenty two per cent of all training occurred during the preseason but 34% of all injuries were sustained in this period. Hamstring, calf, hip flexor/quadriceps, and adductor muscle injuries were the most common for backs, whereas hamstring, lateral ankle ligament, and lumbar disc/nerve root injuries predominated for forwards. Lumbar disc/nerve root, shoulder dislocation/instability, and hamstring muscle injuries for forwards and hamstring muscle and anterior cruciate ligament injuries for backs caused the greatest number of days absence. Running was the predominant cause of injury for both forwards and backs, although the overall incidence and severity of injuries sustained during skills training were significantly greater than those sustained during conditioning training.On average, a club will have 5% of their players unavailable for selection as a consequence of training injuries.
FDA Calls Bovine-Based Vaccines Currently Safe
Authors: C. Marwick
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
疥疮治疗失败的风险因素
Authors: A. Aussy, E. Houivet, V. Hébert, H. Colas‐Cailleux, N. Laaengh, C. Richard, M. Ouvry, C. Boulard, S. Léger, N. Litrowski, J. Benichou, P. Joly
Journal: British Journal of Dermatology (2019)

疥疮是一个重要的全球健康问题。在发展中国家可能受到感染,导致心脏和肾脏疾病。疥疮在发达国家的患病率也正在增高,影响欧洲和美国 2‐4% 人群。这部分是由于治疗不当。已经研究了住院或卧床患者(如养老院中的痴呆患者,他们发生疥疮的风险高)治疗失败的原因。但是,尚未研究门诊患者(即可活动的患者,代表了大多数患者)中的治疗失败。来自法国鲁昂大学皮肤病学系和生物统计学系的作者们试图确定到医院或私人皮肤诊所就诊的疥疮临床诊断患者中治疗失败的预测因素。他们研究了 210 名患者,其中 98 名已成功治疗,112 名在治疗后 3 个月有疥疮持续存在的证据。他们发现,治疗失败的一个主要原因是仅使用苯甲酸苄酯局部外用治疗(用于皮肤)或伊维菌素口服治疗(通过口服),而非联合这两者。另一个主要原因是使用单剂量伊维菌素,而非连续两剂。治疗失败的其他原因包括随食物服用伊维菌素而非推荐的空腹服用、亲属和密切接触者治疗不当、缺乏关于治疗的书面信息和可能的家具清洁不当(一个争议话题)。增加苯甲酸苄酯的使用频率似乎并不影响结局,由于其刺激性,作者并未推荐这一做法。总而言之,作者们认为应在局部外用基础上连续口服两剂伊维菌素(而非一剂)。这对全世界都有意义,因为单剂量伊维菌素在某些国家是推荐治疗。
Abstract C17: Identifying novel genes critical to invasion in head and neck squamous cell carcinoma
Authors: Sangeeta K. Jayakar, Olivier D. Loudig, Margaret Brandwein-Gensler, Kim S. Ryung, Michael B. Prystowsky, Jeffrey E. Segall, Thomas J. Belbin
Journal: Cancer Research (2013)

Abstract Oral cavity squamous cell carcinomas (OCSCC) have a poor patient prognosis, which is attributed to their invasive nature. Our goal was to identify specific genes that are important in OCSCC invasion, utilizing genome-wide expression data generated from HNSCC patient tumor samples of varying degrees of invasiveness. Invasion was assessed using the histological parameter pattern of invasion (POI), which describes the manner in which tumor cells infiltrate the normal tissue at the tumor-host interface. POI was used to categorize tumor resections into five types (1-5), type 5 being the most invasive with a “widely dispersed pattern of tumor infiltrate” and correlated significantly with the appearance of local recurrence and decreased overall survival of the patients after surgery. Global gene expression data was acquired from analysis of the surgical resections from 9 OCSCC patient samples collected at Montefiore Medical Center between 2001 and 2008. Tumor cell-enriched cores from formalin-fixed paraffin-embedded (FFPE) samples were used to generate global gene expression data using the Illumina® WG-DASL array to compare gene expression in four tumors that were WPOI type 5 and five tumors that were WPOI type 3. RNA extracted from flash-frozen tumor samples following surgical resection from the same patients was used to obtain global gene expression data using the Illumina® HumanHT-12 v4 Expression BeadChip. Candidate genes were assessed using in vitro invasion assays following siRNA knockdown of specific gene expression using siGENOME smart pools from Dharmacon. When both gene expression datasets were analyzed, we identified 104 genes that were overexpressed at least 1.5-fold in the WPOI type 5 tumors compared to the less invasive WPOI type 3 tumors. Fifty genes were initially tested based on functional criteria. In our initial screen, 16 of these genes showed a significant reduction in tumor cell invasion when expression was knocked down by siRNA in an OCSCC cell line (UMSCC1). These 16 genes are now being tested in other cell lines as well as in our in vivo mouse model to assess their invasive phenotype. This initial screen of global gene expression data in combination with pattern of invasion has revealed multiple novel genes which may play a critical role in OCSCC invasion and warrant further study. Citation Format: Sangeeta K. Jayakar, Olivier D. Loudig, Margaret Brandwein-Gensler, Kim S. Ryung, Michael B. Prystowsky, Jeffrey E. Segall, Thomas J. Belbin. Identifying novel genes critical to invasion in head and neck squamous cell carcinoma. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Invasion and Metastasis; Jan 20-23, 2013; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2013;73(3 Suppl):Abstract nr C17.
New glaucoma drugs have dramatically decreased the need for operation
Journal: BMJ (2001)

Oral iron can improve motor and language development in preschool children Oral iron supplementation improves motor and language development in iron deficient preschool children.Iron deficiency anaemia is associated with defects in child development.Stoltzfus et al (p 1389) looked at the effects of iron supplementation, anthelmintic treatment, or both in preschool children in Zanzibar, where anaemia and geohelminth infections were prevalent.Iron supplementation in children with serious iron deficiency conferred important benefits to their motor and language development, even in communities where malaria is endemic and is a major cause of anaemia.
Pathology
Authors: Robert A. Goyer
Journal: JAMA (1982)

The practice of pathology has always provided special opportunities to relate mechanisms and causes of disease. The growing potential for adverse health impacts resulting from the large number of chemicals that have been introduced into daily life offers new challenges for the identification and prevention of many rare as well as common diseases. More than 60,000 chemicals are used in industry today; of these, fewer than 40,000 have been tested for adverse health effects. For example, the International Agency for Research on Cancer stated two years ago that only about 450 chemicals currently in common use have been evaluated for carcinogenesis, and human data were available for only about 60.1 Furthermore, about 5,000 chemicals are produced in quantities exceeding 450,000 kg per year, and 300 to 500 new substances are introduced into commerce each year. Over the past decade a broad array of federal legislation has been enacted that has
Abstract 18649: Long-term Outcome and the Mechanisms of Pulmonary Antrum Radial-linear Ablation in Patients With Paroxysmal Atrial Fibrillation
Authors: Xue Zhao, Jianqiang Hu, Yan Huang, Yawei Xu, Yanzhou Zhang, Hui Gong, Zhenguo Liu
Journal: Circulation (2015)

Objectives: The aim of this study was to determine the mechanisms and effectiveness of pulmonary antrum radial-linear (PAR) ablation in comparison with pulmonary vein isolation (PVI) in patients with paroxysmal atrial fibrillation (AF) after a long-term follow-up. Background: The one-year follow up data suggested that PAR ablation appeared to have a better outcome over the conventional PVI for paroxysmal AF. Methods: The enrollment occurred between March, 2011, and August, 2011, with the last follow-up in May, 2014. A total of 133 patients with documented paroxysmal AF were enrolled from 5 centers and randomized to PAR group or PVI group. Event ECG recorder and Holter monitoring were conductedduring the follow-up for all patients. Results: The average procedure time was 151±23 min in PAR group and 178±43 min in PVI group ( P &lt;0.001). The average fluoroscopy time was 21±7 min in PAR group and 27±11 min in PVI group ( P= 0.002). AF triggering foci were eliminated in 59 patients (89.4%) in PAR group, whereas, only 4 patients (6.0%) in PVI group (P&lt;0.001).At median 36 (37-35) months of follow-up after single ablation procedure, 43 of 66 patients in PAR group (65%) and 28 of 67 patients in PVI group (42%) had no recurrence of AF off antiarrhythmic drug (AAD) (P=0.007); and 47 of 66 patients in PAR group (71%) and 32 of 67 patients in PVI group (48%) had no recurrence of AF with AAD (P=0.006). At the last follow-up, the burden of AF was significantly lower in PAR group than in PVI group (0.9% ± 2.3% vs 4.9% ± 9.9%;90th percentile, 5.5% vs 19.6%; P=0.008). No major adverse event (death, stroke, PV stenosis) was observed in all the patients except one case of pericardial tamponade. Conclusions: PAR ablation is a simple, safe, and effective strategy for the treatment of paroxysmal AF with better long-term outcome than PVI. PAR ablation might exhibit the beneficial effect on AF management through multiple mechanisms. Registration: ChiCTR-TRC-11001191
The Secret of Better Health
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 3246: Dynamics of T-cell checkpoint receptor profiles during melanoma progression
Authors: Jarem Edwards, Annie Tasker, Inês Pires da Silva, Camelia Quek, Benjamin M. Allanson, Robyn P. M Saw, John F. Thompson, Alexander M. Menzies, Umaimainthan Palendira, James S. Wilmott, Georgina V. Long, Richard Scolyer
Journal: Cancer Research (2019)

Abstract Background A myriad of novel monoclonal antibody based immunotherapies targeting co-stimulating and co-inhibitory receptors have entered clinical trials in melanoma with the aim of increasing response rates and overcoming resistance to standard anti-CTLA-4 and anti-PD-1 immunotherapy. However, little is known about the abundance, co-expression and immune cells enriched for each specific drug target in the various stages of melanoma progression. Therefore, we sought to assess the relative abundance of checkpoint receptors and their expression during melanoma disease progression, as well as the immune cells enriched for each of these molecules. Methods - Multiplex immunofluorescence staining for immune checkpoint receptors (ICOS, GITR, OX40, PD-1, TIM-3, and VISTA) was performed on 95 melanoma biopsies from 41 melanoma patients, including patient matched biopsies for primary, regional lymph node or distant metastases. - Mass cytometry was performed on leukocytes isolated from 18 treatment-naïve melanoma tumors to explore immune subsets enriched for many of the checkpoint receptors currently targeted in clinical trials. Results &amp; Conclusions GITR and OX40 were the least abundant checkpoint receptors in melanoma (p&amp;lt;0.001), with less than 1% of intra-tumoral T cells expressing either marker. TIM-3 and VISTA were mostly expressed on non-T cell populations, with TIM-3 enriched on dendritic cells. Tissue resident T cells (CD69+ CD103+ CD8+) represented a population highly enriched for TIGIT (&amp;gt;70%) and other co-inhibitory receptors but not co-stimulatory receptors. The proportion of GITR+ T cells decreases from primary melanoma (&amp;gt;5%) to patient matched lymph node (&amp;lt;1%, p=0.04) and distant metastases (&amp;lt;1%, p=0.0005). This data will underpin future clinical trial design and provide a rationale for combining these molecules in the clinic. Note: This abstract was not presented at the meeting. Citation Format: Jarem Edwards, Annie Tasker, Inês Pires da Silva, Camelia Quek, Benjamin M. Allanson, Robyn P. M Saw, John F. Thompson, Alexander M. Menzies, Umaimainthan Palendira, James S. Wilmott, Georgina V. Long, Richard Scolyer. Dynamics of T-cell checkpoint receptor profiles during melanoma progression [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3246.
Accuracy of Recorded Tumor, Node, and Metastasis Stage in a Comprehensive Cancer Center
Authors: James D. Brierley, Pamela A. Catton, Brian O’Sullivan, Janet E. Dancey, Anthony J. Dowling, Jonathan C. Irish, Thomas S. McGowan, Jeremy F.G. Sturgeon, Carol J. Swallow, George B. Rodrigues, Tony Panzarella
Journal: Journal of Clinical Oncology (2002)

The benefits of recording the tumor, node, and metastasis (TNM) stages of cancer patients are well accepted, but little is known about how accurately this is performed. An audit was performed to determine the accuracy of recorded stage and to act as a baseline before the implementation of an education program.All new patient referrals to Princess Margaret Hospital between July 1 and August 31, 1997, were reviewed. An audit panel composed of five health record technicians (HRTs) and 10 doctors was assembled. Each auditor reviewed 10% of the health record. If there was a discrepancy between the stage in the health record and the auditor stage, then the final stage was determined by the audit committee. Analysis of the agreement between the health record, the physician auditor, the HRT auditor, and the final stage was performed.A total of 855 patients were referred with a new diagnosis of a malignancy for which there was a TNM stage system; 833 patients (97.4%) had a stage assigned. There was agreement between the health record stage and final stage in 80% (95% confidence interval [CI], 77% to 82%) of cases for clinical stage, compared with 90% (95% CI, 87% to 92%) for pathologic stage. Of the major site groups, lung was the least accurately recorded. The most common major discrepancies were due to the recording of X when a definite category could be assigned.This audit demonstrates the importance of staging and provides impetus to develop staging guidelines and education programs.
Intraoperative strategies to reduce catheter-related bladder discomfort in the early postoperative period after robot-assisted radical prostatectomy
Authors: H. Veerman, A.P.I. Houwink, P.F.E. Schutte, J.A. Nieuwenhuijzen, T.A. Roeleveld, E. Wit, J.W. Mazel, T.M. Van Der Sluis, A.N. Vis, P.J. Van Leeuwen, H.G. Van Der Poel
Journal: European Urology (2021)
Reference Directories
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
R-Binder Deficiency
Authors: Ralph Carmel
Journal: JAMA (1983)

A patient with R-binder deficiency lacked this cobalamin-binding protein in serum, saliva, gastric juice, and leukocytes, as demonstrated by cobalamin-binding ability and radioimmunoassay. The patient's condition was first detected because of a low serum cobalamin (vitamin B<sub>12</sub>) level. His level of serum cobalamin, however, which was carried largely by transcobalamin II, was not as decreased as in the initial cases reported and was higher by some assays than by others. The demonstration of normal bone marrow morphological appearance and deoxyuridine suppression test findings, lack of attributable neurological dysfunction, and absence of methylmalonic aciduria make clear that deficiency of R binder, whose function is unknown, did not produce notable disturbance of cobalamin metabolism. This entity is probably not as rare as originally thought. It must be considered in the differential diagnosis of low serum cobalamin levels, even among elderly patients, whose conditions often tend to be automatically diagnosed as pernicious anemia. (<i>JAMA</i>1983;250:1886-1890)
Viral imitations of host defense proteins. Flattery that turns to battery
Authors: P. M. Murphy
Journal: JAMA (1994)

<h3>CASE PRESENTATION</h3> A 40-year-old Indian woman with Takayasu's arteritis presented to the National Naval Medical Center with chest pain of 1 day's duration. One year previously, she had presented with malaise, diminished left upper extremity pulses, and an elevated erythrocyte sedimentation rate. A diagnosis of Takayasu's arteritis had been made by angiographic demonstration of stenosis of the left subclavian artery. She had been treated initially with 1 mg/kg per day of prednisone with angiographically evident improvement, and the drug dosage had been tapered over the past year to 10 mg of prednisone every other day. On the day of admission she noted constant, sharp left chest pain without radiation and without dyspnea. Her past medical history was otherwise unremarkable. The physical examination revealed a woman who appeared well nourished. Her temperature was 38.5°C orally. Her heart rate was 92 beats per minute, and her blood pressure was 126/78 mm Hg.
Medical Rehabilitation
Authors: Edward A. Edwards
Journal: JAMA (1986)

This is an excellent work. It devotes most of its attention to disorders likely to lead to long-term disability, seen more often by internists and neurologists than by surgeons. Emphasis is placed on disorders of the heart, lungs, and nervous system (including stroke and head and spinal cord injuries), cancer, arthritis, and other causes of musculoskeletal pain. Amputation is about the only subject covered that is of primary surgical concern. The book is concise—354 pages, including a short appendix identifying sources of equipment and educational materials. The tables and illustrations are well done, assisting the reader in grasping the material. References are well chosen. The presentation embodies two current philosophies in medicine: (1) That physicians must help every patient to perform at his best, given his disability. (2) That rehabilitation can only start in the medical gymnasium of the rehabilitation unit. It is hoped that the patient will learn what
Retinoscopy (or Shadow Test) in the Determination of Refraction at One Meter Distance, with the Plane Mirror.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Book Review Hematology: Thrombosis and Hemorrhage Edited by Joseph Loscalzo and Andrew I. Schafer. 1337 pp., illustrated. Boston, Blackwell Scientific, 1994. $225. 0-86542-263-X Hemostasis and Thrombosis: Basic Principles and Clinical Practice Edited by Robert W. Colman, Jack Hirsh, Victor J. Marder, and Edwin W. Salzman. 1713 pp., illustrated. Philadelphia, J.B. Lippincott, 1994. $195. 0-397-51059-4 The Hemorrhagic Disorders: A Clinical and Therapeutic Approach By Mario Stefanini and William …
Authors: Robert S. Schwartz
Journal: New England Journal of Medicine (1994)