tbuckley/cabot-search huggingface dataset:
HOT WATER RECTAL SYRINGE.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nonurgent emergency department visits. Meeting an unmet need
Authors: A. L. Kellermann
Journal: JAMA (1994)

Americans will visit hospital emergency departments (EDs) more than 90 million times this year.<sup>2</sup>Growth in ED visits has been particularly pronounced among Medicaid and Medicare recipients and uninsured patients.<sup>3</sup>Although many patients seek emergency care for problems that threaten life or limb, most have less serious conditions. Use of the ED for nonurgent care has become so widespread that it is commonly cited as a major contributor to increasing health care costs.<sup>4,5</sup> Federal reports estimate that between 40% and 55% of all ED visits involve nonurgent problems.<sup>3,6</sup>Because care of minor illness or injuries in the ED generates greater charges, on average, than comparable care in a physician's office or outpatient clinic, various administrative and financial strategies have been proposed to divert patients from the ED. It is also assumed that demand for nonurgent care in the ED will decline when everyone is covered by
Refugee health.
Authors: G. Karmi
Journal: BMJ (1992)

eries, mostly associated with multiple pregnancies, but no overall increase in congenital abnormalities.'3Couples worldwide are prepared to make enormous per- sonal sacrifices to have the chance of having a child.In many European countries the governments directly or, through health insurance, indirectly, provide some assisted con- ception.While the glamour of test tube babies should not detract from the need to provide a fully comprehensive infertility service, surely it is time that there was better provision of assisted conception in Britain, where Edwards and Steptoe pioneered in vitro fertilisation.
Regulating spoons
Authors: A. Bush
Journal: European Respiratory Journal (2008)

<h3>Abstract</h3> Cell replacement therapies hold great therapeutic potential. Nevertheless, our knowledge of the mechanisms governing the developmental processes is limited, impeding the quality of differentiation protocols. Generating insulin-expressing cells <i>in vitro</i> is no exception, with the guided series of differentiation events producing heterogeneous cell populations that display mixed pancreatic islet phenotypes and immaturity. The achievement of terminal differentiation ultimately requires the <i>in vivo</i> transplantation of, usually, encapsulated cells. Here we show the impact of cell confinement on the pancreatic islet signature during the guided differentiation of alginate encapsulated human induced pluripotent stem cells (hiPSCs). Our results show that encapsulation improves differentiation by significantly reshaping the proteome landscape of the cells towards an islet-like signature. Pathway analysis is suggestive of integrins transducing the encapsulation effect into intracellular signalling cascades promoting differentiation. These analyses provide a molecular framework for understanding the confinement effects on hiPSCs differentiation while confirming its importance for this process.
Environment
Authors: Bertram D. Dinman
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Estrogen Receptor Accessory Proteins: Effects on Receptor-DNA Interactions
Authors: Carolyn Church Landel, Peter J. Kushner, Geoffrey L. Greene
Journal: Environmental Health Perspectives (1995)

Despite a wealth of information about the structure and composition of steroid receptors and their functional domains, little is known about the role of accessory proteins as mediators of receptor activity.To better define the role of such proteins in estrogen receptor (ER) function, we have used immunoaffinity, steroid affinity, and site-specific DNA-affinity chromatography to identify and characterize proteins that associate with human ER (hER) in extracts from MCF-7 cells and hER-expressing CHO (CHO-ER) cells.In addition to the expected 66-kDa hER, a 70-kDa protein was obtained and subsequently identified as a member of the heat shock protein family (hsp70).A 55-kDa protein, detected by all three approaches, was identified as a member of the protein disulfide isomerase family (PDI).Two proteins that were preferentially retained by an ER-specific DNA affinity column (p48 and p45) remain unidentified.Maximal interaction of purified hER with the vitellogenin A2 estrogen response element (ERE) occurred in the presence of all four associated proteins isolated by DNA-affinity chromatography.The increased stability of this complex was due primarily to an increase in the association rate of hER with ERE.Thus, accessory proteins may be required for optimal interaction of ER with EREs.-
Phenolsulfonphthalein excretion test
Authors: G. Dunea
Journal: JAMA (1968)

The phenolsulfonphthalein (PSP [phenol red]) excretion test was developed by Rowntree and Geraghty in 1910, when chemical determinations were generally unavailable, and assessment of renal function was essentially limited to examination of the urine for protein and sediment. Some measure of popularity, however, had been achieved by tests which depended on the urinary excretion of a foreign dye, such as indigo carmine or methylene blue. The use of phenolsulfonphthalein for this purpose evolved from a search for a subcutaneous purgative, when the high urine excretion and the lack of toxicity of the dye became apparent.<sup>1</sup> <h3>Significance and Usefulness</h3> Phenolsulfonphthalein early assumed significance in several areas. It became one of the first widely used tests for measurement of renal function. The presence of phenolsulfonphthalein in the cortex of a dog with absent glomerular filtration provided the first acceptable evidence of tubular secretion by the mammalian kidney. Recognition of the removal
Effervescent Suppositories
Authors: J. A. Gowers
Journal: BMJ (1964)

in England that provide the same opportunity, and there should be little difficulty to train for final F.R.C.S. in these posts.I am rather sorry to see, yet again, the condemnation of the provincial hospitals by those in teaching centres.These hospitals do the bulk of the work and postgraduate training, and do both these tasks well, with only a few exceptions.It would, however, he helpful if, as in many other specialties, " exchange posts " for.regis- trars could be established between teaching and provincial hospitals.The minimum training requirement in E.N.T. (until recently at any rate) to enable a candidate to sit the final Fellowship in England was six months, and I believe nil in other centres.The general surgical training minimum for E.N.T. candidates of
Intestinal adherence associated with type IV pili of enterohemorrhagic Escherichia coli O157:H7
Authors: Juan Xicohtencatl-Cortes, Valério Monteiro-Neto, Maria A. Ledesma, Dianna M. Jordan, Olivera Francetic, James B. Kaper, José Luis Puente, Jorge A. Girón
Journal: Journal of Clinical Investigation (2007)

Enterohemorrhagic Escherichia coli (EHEC) O157:H7 causes hemorrhagic colitis and hemolytic uremic syndrome (HUS) by colonizing the gut mucosa and producing Shiga toxins (Stx). The only factor clearly demonstrated to play a role in EHEC adherence to intestinal epithelial cells is intimin, which binds host cell integrins and nucleolin, as well as a receptor (Tir) that it injects into the host cell. Here we report that EHEC O157:H7 produces adhesive type IV pili, which we term hemorrhagic coli pilus (HCP), composed of a 19-kDa pilin subunit (HcpA) that is encoded by the hcpA chromosomal gene. HCP were observed as bundles of fibers greater than 10 μm in length that formed physical bridges between bacteria adhering to human and bovine host cells. Sera of HUS patients, but not healthy individuals, recognized HcpA, suggesting that the pili are produced in vivo during EHEC infections. Inactivation of the hcpA gene in EHEC EDL933 resulted in significantly reduced adherence to cultured human intestinal and bovine renal epithelial cells and to porcine and bovine gut explants. An escN mutant, which is unable to translocate Tir, adhered less than the hcpA mutant, suggesting that adherence mediated by intimin-Tir interactions is a prelude to HCP-mediated adherence. An hcpA and stx1,2 triple mutant and an hcpA mutant had similar levels of adherence to bovine and human epithelial cells while a stx1,2 double mutant had only a minor defect in adherence, indicating that HCP-mediated adherence and cytotoxicity are independent events. Our data establish that EHEC O157:H7 HCP are intestinal colonization factors that are likely to contribute to the pathogenic potential of this food-borne pathogen.
Thymidylate synthase activity as a significant prognostic marker in patients with renal cell carcinoma
Authors: Y. Mizutani, H. Nakanishi, T. Nakamura, T. Nomoto, K. Mikami, K. Okihara, O. Ukimura, A. Kawauchi, A. Fujito, T. Miki
Journal: Journal of Clinical Oncology (2004)

4630
Review of 347 Transtracheal Bronchograms
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Increasing number of medical organizations adopting policies relating to tobacco use
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BERLIN
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue Access Provided by Korea University Medical Library JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account
Use of Activity Measures in Behavioral Toxicology
Authors: Lawrence Reiter
Journal: Environmental Health Perspectives (1978)

Locomotor activity measurements have been used extensively to evaluate chemically-induced changes in CNS function. This paper focuses on several factors including apparatus, age, biological rhythm, and social setting, which influence both locomotor activity levels per se and chemically induced changes in these activity levels. These data illustrate that failure to recognize, specify, and consider these factors is likely to result in equivocal studies subject to possible misinterpretation.
A cutaneous clue to mammary carcinoma. Paget's disease of the nipple
Authors: K. M. Halprin
Journal: JAMA (1967)

The first of the three illustrations should cause no concern. The condition pictured in Fig 1 will respond to proper antipsoriasis therapy. However, Fig 2 and 3 illustrate a condition which requires prompt surgical intervention. The difficulty involved in the clinical distinction between the benign lesion of psoriasis and the malignant lesion of Paget's disease of the nipple is obvious. In Paget's disease of the nipple, the normal epidermal cells are replaced by large, pale-staining cells which lack the normal intercellular attachments of epidermal cells. In addition their cytoplasm stains positively for mucin when the alcianblue technique is used. These pale large cells are malignant in themselves, and are always associated with an underlying mammary carcinoma which is usually of the intraductal type. Presumably, the malignant ductal cells proliferate up the duct and eventually out into the epidermis of the nipple. There they do not form a tumor mass but
Melatonin for Insomnia in Children
Journal: JAMA (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Quality of Life After Aortic Valve Replacement at the Age of &gt;80 Years
Authors: Thoralf M. Sundt, Marci S. Bailey, Marc R. Moon, Eric N. Mendeloff, Charles B. Huddleston, Michael K. Pasque, Hendrick B. Barner, William A. Gay
Journal: Circulation (2000)

Background —The optimal management of aortic valve disease in patients &gt;80 years old depends on functional outcome as well as operative risks and late survival. Methods and Results —We retrospectively identified 133 patients (62 men, 71 women) aged 80 to 91 years (mean 84±3 years) who underwent aortic valve replacement alone or in combination with another procedure between January 1, 1993, and April 31, 1998. Demographics included hypertension 68%, diabetes mellitus 17%, and history of stroke 11%. Operative (30 day) mortality rate was 11%. Urgent or emergent surgery, aortic insufficiency, and perioperative stroke or renal dysfunction were risk factors for operative death by multivariable analysis. Intensive care unit and total hospital length of stay were prolonged at 6.2 and 14.7 days, respectively. Late follow-up between July 1, 1998, and November 1, 1999, was 98% complete. Actuarial survival at 1 and 5 years was 80% and 55%, respectively. Predictors of late mortality were preoperative or perioperative stroke, chronic obstructive pulmonary disease, aortic stenosis, and postoperative renal dysfunction. The mean New York Heart Association functional class for 65 long-term survivors improved from 3.1 to 1.7. Quality of life assessed with the Medical Outcomes Study Short Form-36 was comparable to that predicted for the general population &gt;75 years old. Conclusions —Functional outcome after aortic valve replacement in patients &gt;80 years old is excellent, the operative risk is acceptable, and the late survival rate is good. Surgery should not be withheld from the elderly on the basis of age alone.
Highlights
Journal: JAMA Surgery (2019)

In this prospective surveillance study, Armer and colleagues examined factors associated with lymphedema, a well-known complication of breast cancer treatment, after neoadjuvant chemotherapy and axillary dissection in 486 women with node-positive breast cancer.Obesity (body mass index Ն30) was associated with lymphedema symptoms, and neoadjuvant chemotherapy lasting 144 days or longer was associated with 20% limb-volume increase.Patients with longer neoadjuvant chemotherapy duration or obesity may have higher lymphedema risk and may benefit from enhanced prospective surveillance.
Enhanced Expression of the Protein Kinase Substrate Annexin I in Human Hepatocellular Carcinoma
Authors: T Masaki, M Tokuda, M Ohnishi, S Watanabe, T Fujimura, K Miyamoto, T Itano, H Matsui, K Arima, M Shirai, T Maeba, K Sogawa, R Konishi, K Taniguchi, Y Hatanaka, O Hatase, M Nishioka
Journal: Hepatology (1996)

Annexin (AX) constitutes a new family of Ca2+–dependent membrane–binding proteins; 13 of them have been described. Among these, annexin–1 (AX–I) has displayed many biological functions in vitro . Its actual role in vivo , however, remains unknown. We already reported that AX–I was expressed in proliferating (regenerating) hepatocytes at both protein and messenger RNA (mRNA) levels. The role of AX–I in human hepatocellular carcinoma (HCC) remains obscure. In this study, the amounts of AX–I at protein and mRNA levels, as well as its localization, have been determined in the normal human liver, chronic hepatitis liver, and nontumorous and tumorous portions of HCC. AX–I was rarely found in normal and chronic liver tissues, whereas it is overexpressed at both the transcriptional and translational levels in tumorous and nontumorous regions of HCC. In addition, more AX–I was expressed in the tumorous portion than the nontumorous portion of HCC. AX–I was present in the hepatocytes and HCC cells, localized mainly in the cytoplasm. AX–I was expressed in poorly differentiated cancer cells. Furthermore, AX–I was tyrosine–phosphorylated in HCC. We also found that some of the AX–I–positive hepatocytes in the nontumorous tissues were derived from a particular subset of parenchymal cells (stem or oval cells). These results indicate that AX–I plays an important role in the malignant transformation process leading to HCC and that it is closely related to the histological grade of HCC. HCC would offer a novel tool with which to study the function of AX–I in malignant transformation.
Atlas of Pediatric Nuclear Cardiology: Part II
Authors: J R STY
Journal: Clinical Nuclear Medicine (1980)

Cardiovascular nuclear medicine is an extremely useful clinical tool. The full potential of nuclear techniques in pediatrics has only recently been realized. Depending on the child's problem, one may choose to perform qualitative radionuclide angiography, first-pass studies, gated blood pool studies, myocardial perfusion imaging, particle imaging, or a combination of these studies. The examinations are sensitive, noninvasive, accurate, and available on the clinical level.