tbuckley/cabot-search huggingface dataset:
Vulnerable Periods and Processes during Central Nervous System Development
Authors: Patricia M. Rodier
Journal: Environmental Health Perspectives (1994)

The developing central nervous system (CNS) is the organ system most frequently observed to exhibit congenital abnormalities.While the developing CNS lacks a blood brain barrier, the characteristics of known teratogens indicate that differential doses to the developing vs mature brain are not the major factor in differential sensitivity.Instead, most agents seem to act on processes that occur only during development.Thus, it appears that the susceptibility of the developing brain compared to the mature one depends to a great extent on the presence of processes sensitive to disrup- tion.Yet cell proliferation, migration, and differentiation characterize many other developing organs, so the difference between CNS and other organs must depend on other properties of the developing CNS.The most important of these is probably the fact that nervous system development takes much longer than development of other organs, making it subject to injury over a longer period.
Behavioral Testing as a Method for Assessing Risk
Authors: Richard E. Butcher
Journal: Environmental Health Perspectives (1976)

Behavioral effects have been found to result from the prenatal administration of substances known to be teratogenic to the CNS. These effects occur at dose levels lower than those producing gross malformations and when the agent is administered at times other than that optimal for CNS relevant technique for detecting adverse consequences of prenatal exposure to drugs and chemicals. Behavioral testing, however, also appears to have attributes that dictate a thoughtful approach to its role as a method for assessing risk, and additional research is needed to obtain usable techniques. The need for such research is intensified by the present inability to identify potential behavioral teratogens by means other than laboratory investigation.
“Benign”
Authors: Kate E. Lee
Journal: JAMA Oncology (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Poor Americans often misinterpret labels on drug bottles
Journal: BMJ (2006)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following Poor Americans often misinterpret labels on drug bottles Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Aurora A Kinase Inhibition Is Synthetic Lethal with Loss of the <i>RB1</i> Tumor Suppressor Gene
Authors: Xueqian Gong, Jian Du, Stephen H. Parsons, Farhana F. Merzoug, Yue Webster, Philip W. Iversen, Li-Chun Chio, Robert D. Van Horn, Xi Lin, Wayne Blosser, Bomie Han, Shaoling Jin, Sufang Yao, Huimin Bian, Chris Ficklin, Li Fan, Avnish Kapoor, Stephen Antonysamy, Ann M. Mc Nulty, Karen Froning, Danalyn Manglicmot, Anna Pustilnik, Kenneth Weichert, Stephen R. Wasserman, Michele Dowless, Carlos Marugán, Carmen Baquero, María José Lallena, Scott W. Eastman, Yu-Hua Hui, Matthew Z. Dieter, Thompson Doman, Shaoyou Chu, Hui-Rong Qian, Xiang S. Ye, David A. Barda, Gregory D. Plowman, Christoph Reinhard, Robert M. Campbell, James R. Henry, Sean G. Buchanan
Journal: Cancer Discovery (2018)

Loss-of-function mutations in the retinoblastoma gene RB1 are common in several treatment-refractory cancers such as small-cell lung cancer and triple-negative breast cancer. To identify drugs synthetic lethal with RB1 mutation (RB1 mut), we tested 36 cell-cycle inhibitors using a cancer cell panel profiling approach optimized to discern cytotoxic from cytostatic effects. Inhibitors of the Aurora kinases AURKA and AURKB showed the strongest RB1 association in this assay. LY3295668, an AURKA inhibitor with over 1,000-fold selectivity versus AURKB, is distinguished by minimal toxicity to bone marrow cells at concentrations active against RB1 mut cancer cells and leads to durable regression of RB1 mut tumor xenografts at exposures that are well tolerated in rodents. Genetic suppression screens identified enforcers of the spindle-assembly checkpoint (SAC) as essential for LY3295668 cytotoxicity in RB1-deficient cancers and suggest a model in which a primed SAC creates a unique dependency on AURKA for mitotic exit and survival. SIGNIFICANCE: The identification of a synthetic lethal interaction between RB1 and AURKA inhibition, and the discovery of a drug that can be dosed continuously to achieve uninterrupted inhibition of AURKA kinase activity without myelosuppression, suggest a new approach for the treatment of RB1-deficient malignancies, including patients progressing on CDK4/6 inhibitors.See related commentary by Dick and Li, p. 169.This article is highlighted in the In This Issue feature, p. 151.
ORIGINAL INVESTIGATIONS ON THE NATURAL HISTORY, (SYMPTOMS AND PATHOLOGY) OF YELLOW FEVER. 1854-1894.
Authors: JOSEPH JONES
Journal: JAMA (1895)

<h3>Chapter III.</h3><h3>Case 2.</h3> —Yellow fever: high temperature, 106.5 degrees in axilla; suppression of urine; black vomit; recovery; treatment, ice water injections to rectum; application of ice to epigastrium; sulpho-carbolate of sodium internally. Dominick Polmisano; age 18; native of Italy. Has resided in New Orleans six years; residence St Anne Street near levee. Black hair, black eyes, dark complexion. Had a slight chill, followed by pain in the head and back and fever. Oct. 14, 1873. Entered Charity Hospital, October 16, at 4:30 P.M. At this time the patient had high fever; hot skin; face very red with great capillary congestion of the surface generally. Capillaries of conjunctivæ, greatly congested and of a yellowish tinge. Body emits an offensive smell. Breath very offensive. Tongue red at tip and edge and coated with light yellow fur shading into brown in the center and root of the tongue. Gums very red. Patient
Human pulmonary dirofilariasis manifesting as a "coin" lesion. A case report
Authors: R. A. Tuazon
Journal: JAMA (1967)

DIROFILARIA or heartworm is a common parasite of dogs, cats, and other mammals. It is rarely encountered in human beings. Recently, two cases of human pulmonary dirofilariasis were reported by Harrison and Thompson.<sup>1</sup>In their review of the literature they found only three cases up to 1965. Extrapulmonary human dirofilariasis is the more common form of human infestation by this parasite. Faust<sup>2</sup>in 1957 reviewed the literature and collected 37 cases, most of them were found in southern Europe. Four of the cases of human pulmonary dirofilariasis mentioned above presented as a "coin" lesion in a roentgenogram of the chest. The fifth case presented as a pulmonary infarct with pneumonitis. Because of this clinical pattern, human pulmonary dirofilariasis should be considered in the differential diagnosis of "coin" lesion of the lung. The following case is being reported to add to the small list of cases of human pulmonary
Hepatic injury possibly induced by verapamil
Authors: D. T. Nash
Journal: JAMA (1983)

VERAPAMIL hydrochloride is a calcium channel-blocking drug used to treat supraventricular tachycardia and angina pectoris. Since it produces a reduction in vascular resistance, we studied it as an antihypertensive agent. This report describes a middle-aged woman who received verapamil therapy for hypertension and who experienced hepatic dysfunction manifested by enzymatic changes and mild systemic and localized symptoms. <h3>Report of a Case</h3> The patient is a 61-year-old woman. Her history was essentially noncontributory, except for a strong family history of hyperlipidemia and hypertension. She was receiving no prescription medications. A physical examination at the time of her initial visit on March 31, 1982, confirmed the diagnosis of essential hypertension. Funduscopy showed arteriovenous nicking, and a grade 1, late systolic murmur was detected by auscultation. A chest x-ray film showed clear lung fields and a minimally widened aorta; ECG was normal. There was no peripheral edema, no hepatomegaly, no ascites, or any
Otogenous Tetanus
Authors: Amos S. Deinard
Journal: JAMA (1980)

<h3>To the Editor.—</h3> We have recently had the opportunity to care for an 18-month-old male Hmong refugee who was hospitalized with tetanus one week after an otological examination in a health screening clinic. We believe that the manner in which he became infected is sufficiently unusual that it should be brought to the attention of the medical community in view of the escalating immigration of Indochinese refugees to this country. <h3>Report of a Case.—</h3> The patient was seen in the screening clinic within ten days of arrival in the United States from a northern Thailand refugee camp. Immunization history indicated that he had been given an injection in the refugee camp at 10 months of age, but it could not be determined that it was a dipropyltryptamine immunization. The patient's clinical examination findings were entirely normal except that the tympanic membranes were totally obscured by cerumen. An unsuccessful attempt was
Randomized trial of cisplatin and etoposide in combination with veliparib or placebo for extensive stage small cell lung cancer: ECOG-ACRIN 2511 study.
Authors: Taofeek Kunle Owonikoko, Suzanne Eleanor Dahlberg, Gabriel Sica, Lynne I. Wagner, James Lloyd Wade, Gordan Srkalovic, Bradley Walter Lash, Joseph W. Leach, Ticiana A.B. Leal, Charu Aggarwal, Suresh S. Ramalingam
Journal: Journal of Clinical Oncology (2017)

8505 Background: Veliparib, a potent inhibitor of Poly (ADP) ribose polymerase (PARP) enzyme potentiates standard chemotherapy against small cell lung cancer (SCLC) in preclinical studies. We evaluated the combination of veliparib (V) with cisplatin/etoposide (CE) doublet for first-line therapy of extensive stage SCLC (ES-SCLC). Methods: Patients with ES-SCLC stratified by gender and serum LDH levels, were randomized to receive four 3-wk cycles of CE (75mg/m 2 and 100 mg/m 2 ) along with V (100mg bid on d1-7) or placebo (P). The primary endpoint was progression-free survival (PFS); secondary endpoints included overall survival (OS). Using an overall one-sided 0.10 level logrank test, this study had 88% power to detect a 37.5% reduction in the PFS hazard rate. Results: 128 eligible pts were enrolled across 33 US sites. Median age, 66 yrs; men, 52%; PS 0/1 (29%/71%). The estimated median PFS was 6.1 m vs. 5.5 m [unstratified HR: 0.75; 1-sided p = 0.06) favoring CE+V. The median OS was 10.3 m vs. 8.9 m respectively for CE+V and CE+P [stratified HR: 0.83 (80% CI 0.64-1.07); 1-sided p = 0.17]. There was a significant treatment by strata interaction in PFS: male pts with high LDH derived benefit [PFS HR of 0.34 (80% CI: 0.22-0.51)]; among pts not in this strata: PFS HR = 0.81 (80% CI: 0.60-1.09). The best objective response rate was 71.9% vs. 65.6% (2-sided p = 0.57). Salient grade ≥3 adverse events occurring in 5% of patients are summarized in the table below. Analysis of tumor samples for predictive biomarkers is planned. Conclusions: The addition of veliparib to doublet chemotherapy was associated with improved PFS in patients with extensive stage SCLC. Clinical trial information: NCT01642251. [Table: see text]
Abdominal Surgery
Authors: Claude E. Welch
Journal: New England Journal of Medicine (1955)

THE last report on this subject in the Journal appeared two years ago. For this review papers have been studied that either are outstanding or are indicative of particular trends in abdominal surgery. It should be realized that only very brief abstracts can be presented and that this survey is merely a guide to many contributions that should be studied in their original form.StomachCancerTotal gastrectomy as a routine operation for cancer has continued to lose popularity. In a survey of opinions of many leading American surgeons on the subject of superradical cancer surgery, Fisher1 reported that not . . .
Ultraviolet Solid-state Laser (213-nm) Photorefractive Keratectomy
Authors: Qiushi Ren, Gabriel Simon, Jean-Marc Legeais, Jean-Marie Parel, William Culbertson, Jinhui Shen, Yoshiko Takesue, Michele Savoldelli
Journal: Ophthalmology (1994)

Background:The pulsed ultraviolet 213-nm solid-state laser has been demonstrated as an alternative to the gas argon-fluoride 193-nm excimer laser for photorefractive keratectomy (PRK).The authors studied the clinical course and histopathologic changes occurring in rabbit corneas after PRK with a 213-nm solid-state laser.Methods: The 213-nm output of neodymium:YAG frequency-quintupled laser was used to create 5-mm optical zone ablations in seven pigmented rabbit corneas.The radiant exposure was 250 mJ/cm 2 delivered through a computer-controlled scanning delivery system with a spot size of 0.5 mm.The target ablation was 4.0 diopters with an estimated ablation depth of 40 ,um.A clinical estimate of corneal epithelial healing and stromal haze was made at intervals over the 3-month study period.Animals were killed immediately after ablation, or at 10 days, 1 month, or 3 months after ablation.Corneal tissue was preserved for light microscopy and transmission electron microscopy at each study interval.Results: All corneas re-epithelialized within 10 days postoperatively.Anterior stromal haze was clinically visible at 3 days, increased until approximately 1 month, and then gradually decreased over the succeeding 2 months.Residual subepithelial haze was visible at 3 months.Results of histopathologic study documented normal epithelium healing over time; the basement membrane retained its regular thickness and hemidesmosomes were abundant at 3 months.The anterior stroma had an increased number of fibroblasts at 10 days, many of which remained until 1 month.A mild, transient, cellular reaction occurred throughout the thickness of the stroma and the endothelium.Conclusion: Using the 213-nm ultraviolet solid-state laser with a scanning delivery system, PRK shows a similar clinical course and histopathologic findings to the 193nm excimer PRK study in rabbits.It is a clinically viable procedure for refractive surgery and requires further human clinical trials to determine its efficacy.
Manuscripts Approved for JNCI, April 15 to May 15, 1960
Journal: JNCI Journal of the National Cancer Institute (1960)

Journal Article Manuscripts Approved for JNCI, April 15 to May 15, 1960 Get access JNCI: Journal of the National Cancer Institute, Volume 24, Issue 6, June 1960, Page 1463, https://doi.org/10.1093/jnci/24.6.1463 Published: 01 June 1960
Urea-induced ROS generation causes insulin resistance in mice with chronic renal failure
Authors: Maria D’Apolito, Xueliang Du, Haihong Zong, Alessandra Catucci, Luigi Maiuri, Tiziana Trivisano, Massimo Pettoello-Mantovani, Angelo Campanozzi, Valeria Raia, Jeffrey E. Pessin, Michael Brownlee, Ida Giardino
Journal: Journal of Clinical Investigation (2014)
Quality of Life in Elderly Patients with Acute Myeloid Leukemia.
Authors: Esther N. Oliva, Roberto Latagliata, Iolanda Vincelli, Giorgina Specchia, Francesca Ronco, Vincenzo Liso, Stefana Impera, Caterina Alati, Alessandra Quota, Giuliana Alimena, Massimo Breccia, Ida Carmosino, Francesco Fortugno, Francesco Nobile
Journal: Blood (2006)
Exfoliative Excrement
Authors: Jorge Roman, Sarah D. Reynolds
Journal: JAMA Dermatology (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
In this issue
Authors: Peter Kirkpatrick, Alexandra Flemming, Charlotte Harrison, Sarah Crunkhorn, Monica Flight, Asher Mullard, Man Tse, Mariam Faruqi, Catriona Rodwell, Isabel Woodman, Lucie Wootton, Lewis Packwood, Susanne Harris, Vicky Summersby, Patrick Morgan, Kirsten Managing, Judith Shadwell, Simon Fenwick, Natalie Smith, Laura Corns, Ella Lines, Dipti Shah, Marketing Managers, Tim Redding, Nazly De, La Rosa, Peter Collins
Journal: Nature Reviews Drug Discovery (2012)
Are there too many female medical graduates? No
Authors: Jane Dacre
Journal: BMJ (2008)

UK universities are now producing more female doctors than male. <b>Brian McKinstry</b> (doi: 10.1136/bmj.39505.491065.94) argues we are risking future staffing problems, but <b>Jane Dacre </b>thinks there is still some way to go before we reach true equality
PROPOSED REDUCTION OF THE MEDICAL CORPS OF THE ARMY.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Outbreak of Influenza A Infection—Alaska and the Yukon Territory, June-July 1998
Journal: JAMA (1998)

Since July 26, CDC and Health Canada, in cooperation with local public health authorities, have been investigating reports of febrile respiratory illness and associated pneumonia among persons traveling on land and sea, both independently and on tour packages, in Alaska and the Yukon Territory. Commonly reported symptoms include fever and cough, and laboratory evidence suggests that influenza A infection may be a cause of many of the illnesses. Summertime outbreaks of influenza A have previously been reported among tourists in the United States and Canada. No evidence suggests increased respiratory illness activity among residents of these areas.
Typo in In-Text Citation
Journal: JAMA Psychiatry (2018)

Error in Table Column Heading: In the Original Investigation titled "Development and Validation of a Clinically Based Risk Calculator for the Transdiagnostic Prediction of Psychosis," 1 published online March 29, 2017, there was an error in the third column heading of Table 2.The column heading should read "Harrell C a ."Additionally, all values in the 2 subcolumns should have a zero in front of the decimal place.This article was corrected online.
Celiac Disease: Study of Jejunal Epithelium Before and After Gluten-Free Diet
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal