tbuckley/cabot-search huggingface dataset:
JEAN MARTIN CHARCOT.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CA209-9DX: Phase III, randomized, double-blind study of adjuvant nivolumab vs placebo for patients with hepatocellular carcinoma (HCC) at high risk of recurrence after curative resection or ablation
Authors: M.J. Jimenez Exposito, M. Akce, J.L.M. Alvarez, E. Assenat, L.A. Balart, A.D. Baron, T. Decaens, A. Heurgue-Berlot, A.O. Martin, S.W. Paik, V. Poulart, A.S. Sehbai, M. Shimada, N. Takemura, J.-H. Yoon
Journal: Annals of Oncology (2018)
Exercise-Induced Asthma
Authors: C. Warren Bierman
Journal: JAMA (1975)

The relative effectiveness of ephedrine, theophylline, and hydroxyzine hydrochloride and their combinations was studied in a two-part investigation of 16 youths who had asthma and exercise-induced asthma. The beneficial and adverse effects of the drugs in the control of asthma were studied in the first part of the investigation. Both theophylline and ephedrine were judged superior to placebo when given alone. When combined they were somewhat more effective than either agent alone, although adverse effects precluded their use in almost half of the subjects. The addition of hydroxyzine diminished the side effects sufficiently to make the combination acceptable to four subjects who refused to take ephedrine/theophylline. In the second part of the study, the relief of exercise-induced asthma was evaluated. Ephedrine had no effect, hydroxyzine had a weak effect on hastening recovery, but theophylline modified the postexercise response significantly. The three drugs together produced an additive effect superior to that of theophylline alone. (<i>JAMA</i>234:295-298, 1975)
Abstracts
Journal: Annals of the Rheumatic Diseases (1967)

Rheumatoid ArthritisSyndromes, Sciatica, etc. was found that side-effects with SMP were minor and often transitory; SMP seemed more effective than SD for preventing streptococcal infections but not rheumatic recurrences, although benzathine penicillin was superior in both these respects.The authors conclude that SMP might be of value in long-term antirheumatic prophylaxis, but more extensive clinical trials would be needed to investigate the possibility.158 on July 23,
Abstract 19921: Influence of Obstructive Sleep Apnea in the Clinical Presentation of Acute Coronary Syndrome: Bedside Polysomnography Study
Authors: Fatima D Cintra, Fabrizio U Maroja, Angelo de Paola, Luciana Storti, Adriano M Caixeta, Ana Paula G Leoncio, Antonio Carlos C Carvalho, Sergio Tufik, Dalva Poyares
Journal: Circulation (2015)

Introduction: Obstructive Sleep Apnea (OSA) is characterized by sleep fragmentation and repetitive hypoxia during sleep and has been associated with arterial hypertension, atrial fibrillation, coronary artery disease, and cardiovascular mortality. OSA has also been extensively linked with atherogenesis. Hypothesis: We sought to evaluate the role of OSA on clinical and angiographic patterns in patients admitted with acute coronary syndrome (ACS). Methods: Patients who were admitted with ACS in intensive care unit (ICU), aged over 20 years old, and with no previous diagnosis or treatment for OSA were consecutively selected between June 2013 and June 2014. A bedside overnight full polysomnography (PSG) was performed using an EMBLA digital system® within second day of admission. All patients underwent transthoracic echocardiogram. The time between pain onset and treatment (TPT) were obtained for all patients. The sample was divided into 3 groups: G1: non OSA; G2: mild to moderate OSA and G3: severe OSA according to the apnea/hypopnea index (AHI) obtained by PSG recordings. All patients signed an informed consent form. ANOVA and GLM followed by Bonferroni test were used, p&lt;0.05. Results: One hundred twenty ACS patients, 58 ± 12 y were included. Seventy-seven% underwent pharmacoinvasive strategy and 23% to primary percutaneous coronary angioplasty. Age and BMI were higher in G3 (p&lt;0.05). The TPT and left ventricle ejection fraction were different between G1, G2 and G3 [(241.44±186.43; 202.13±132.54; 400.5±469.01), p=0.02] and [(51.29±8.95; 50.82±10.57; 45.25±7.44), p=0.04], respectively. After controlling for potential confounder, AHI was independently associated with delay in the onset treatment (p=0.004). The Syntax score was higher in G3 compared with G2 and G1 [(14.15±10.19; 14.46±11.09; 21.33±10.42), p=0.03], respectively. Conclusion: In ACS patients, severe OSA was associated with more complex coronary artery disease at hospital presentation, lower left ventricle ejection fraction., as well as in the delay of onset of treatment.
Safety, anti-tumour activity, and biomarker results of the HER2-targeted bispecific antibody ZW25 in HER2-expressing solid tumours
Authors: F. Meric-Bernstam, D. Hanna, M. Beeram, K.-W. Lee, Y.-K. Kang, J. Chaves, J. Lee, R. Goodwin, C. Vaklavas, D.-Y. Oh, S.Y. Rha, E. Elimova, J. Mayordomo, C. Ferrario, M.A. Cobleigh, A. Fortenberry, G. Rowse, T. Gray, R. Lai, E. Hamilton
Journal: Annals of Oncology (2019)
Incorrect Wording.
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Wilms tumor in an adult associated with androgen abuse
Authors: J. Prat
Journal: JAMA (1977)

AN INSTANCE of Wilms tumor in an adult man who had used large amounts of anabolic androgenic steroids as part of a body-building program is reported. The association of tumors of the liver with use of anabolic steroids has been increasingly documented in recent years, but, to the best of our knowledge, these drugs have not been associated with development of embryonal neoplasms of other organs.<sup>1</sup> <h3>Report of a Case</h3> A 38-year-old man with a two-year history of increasing left flank pain was admitted to The New York Hospital-Cornell Medical Center for examination of a renal mass identified at another hospital. He gave a history of having been involved in competitive body building, but an unusual drug history was not elicited from him. Sonography showed a mass 7 cm in diameter in the upper half of the left kidney and also suggested an infiltrative process in the lower half
Oral amphotericin for candidiasis in patients with hematologic neoplasms. An autopsy study
Authors: E. Z. Ezdinli
Journal: JAMA (1979)

Autopsy examinations were conducted in 72 patients with hematologic malignant neoplasms who received antibacterial therapy before their deaths. These patients were participants in a large double-blind study designed to assess the efficacy of oral amphotericin B in decreasing the incidence of candidal infection. The patients received either 50 mg of amphotericin B orally four times a day, or they received a matching placebo. Eight of 33 patients (24%) who had received placebo and two of 39 (5%) who had received amphotericin had histopathologic evidence of disseminated candidiasis. We conclude that in these patients with hematologic malignant neoplasms who received antibiotics within two weeks of death, the concomitant oral administration of amphotericin was effective in decreasing the incidence of systemic candidal infections, indicating that the gastrointestinal tract serves as a portal of entry for<i>Candida albicans</i>. (<i>JAMA</i>242:258-260, 1979)
Medical News
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prognostic significance of nucleolar organizer regions in hepatocellular carcinoma
Authors: K SHIMIZU
Journal: Hepatology (1995)

It has been suggested that the number of argyrophilic nucleolar organizer regions (AgNORs) correlates with cellular activity and the aggressiveness of malignancy. The mean number of AgNORs per nucleus may, therefore, be a prognostic factor for hepatocellular carcinoma (HCC). The purpose of this study was to evaluate the prognostic significance of the number of AgNORs in HCC. The silver-staining technique was applied to surgically resected specimens to indicate AgNORs. Eightynine of the specimens were of HCC, 23 were of normal liver adjacent to HCC, and 32 were of cirrhotic liver adjacent to HCC. The number of AgNORs of HCC (mean ± SD, 3.26 ± 1.23) was significantly higher than those of normal liver (1.37 ± 0.13) and cirrhotic liver (1.49 ± 0.14). The number of AgNORs was significantly correlated with serum alpha-fetoprotein level, tumor size, portal vein invasion, and Edmondson-Steiner histological grade. In patients undergoing curative resection, the survival rate of those with a high number (>3.04) of AgNORs was significantly worse than that of those with a low number (≤3.04) of AgNORs. Multivariate analysis showed that the number of AgNORs was a significant prognostic indicator in patients without portal vein invasion, and portal vein invasion was the only significant variable when all patients undergoing curative resection were assessed together. The results of this study suggest that the number of AgNORs is useful as an indicator of the grade of malignancy and as a predictor of the prognosis of patients with HCC who do not have portal vein involvement. (HEPATOLOGY 1995;21:393–397.)
A BILL TO ESTABLISH A DEPARTMENT OF PUBLIC HEALTH.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 4096: Clinical study of personalized neoantigen-based cancer vaccine in the treatment of advanced SCLC patients with brain metastasis: A case report
Authors: Song Gao, Yongchao Li, Zhenyu Ding, Heng Xu, Jiaqian Wang, Xianling Guo, Juemin Fang, Guochao Wei, Huanlong Qin, Yuquan Wei, Qing Xu, Li Yang
Journal: Cancer Research (2019)

Abstract Background: Tumor neoantigens arising from somatic mutations are less likely to be subjected to central immune tolerance and therefore the attractive targets for designing cancer vaccine. The personalized neoantigen-based cancer vaccine, a passive immunotherapy based on the theory of adaptive immune responses, has been developed rapidly in recent years. Case Presentation: A 75-year-old male small cell of lung carcinoma (SCLC) patient with brain metastasis, who have experienced multiple chemotherapy resistance, and disease relapse after PD-1 therapy, was enrolled in this study. Whole-exome sequencing (WES) and RNA-seq were used to evaluate patient’s mutation burden and to predict the potential neoantigens. Twelve neoantigen peptides were selected and then were synthesized to generate autologous dendritic cell (DC)-based neoantigen vaccine. At last, 1.5 × 108 DC-based neoantigen vaccine was subcutaneously injected into the patient’s body to evaluate the treatment efficacy. By following-up to 10 months after vaccination, we observed an objective response with all brain metastases regressed. The immunogenicity of each of the 12 neo-epitope administered in this study was analyzed by IFNγ ELISpot in CD4+ and CD8+ T cells in pre- and post-vaccination blood samples. Responses were detected against 66.67% (8/12) of the predicted neo-epitope. Conclusions: The autologous DC-based neoantigen cancer vaccine can effectively trigger a positive immune response to patients’ tumor and prolong patients’ survival. The vaccination can also augment the anti-tumor response of T cells by targeting other nonsynonymous mutation-derived neoepitopes. Therefore, these data demonstrated that the autologous DC-based neoantigen cancer vaccine is safe and effective in eliciting a broad antitumor immunity. Moreover, our work has introduced a framework for testing neoantigen-based vaccine combinatorial strategies in patients with advanced recurrent cancers. Citation Format: Song Gao, Yongchao Li, Zhenyu Ding, Heng Xu, Jiaqian Wang, Xianling Guo, Juemin Fang, Guochao Wei, Huanlong Qin, Yuquan Wei, Qing Xu, Li Yang. Clinical study of personalized neoantigen-based cancer vaccine in the treatment of advanced SCLC patients with brain metastasis: A case report [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4096.
THE MODERN TREATMENT OF FRACTURES
Authors: B. Hunt
Journal: BMJ (1855)

olbee morbid appeance, besides the softened cord, which * CMorte exaSn1nation revealed, was of a character bunally asoiated with,and implie, a constitutional emekESla or nutrient derangements vis., a wazy and fatty rnr.Ant thi oadition of liver 9nSct b taken as evi- d_ens of a eding cacheri.It fh7 hAY6 bee the ,..at of nutrit chne oons M at local disease.Paty lie is vey fp of phthisis, but, n fir as my obemdoa to"s, usually in connexion with such conditions as imply impaired oxygenating power of the lungs.Now, although in the present case the imme- diate cause of death was not, as often happens in similar cases, from paralysis of the diaphragm and respiratorymuscles, yet there was considerable and protracted impair- ment of the respiatory process.There was very imperfect action of the lungs, as indicated by the breathing, and the collection of pulmonary secretion, giving rise to short, fre- quent, and ineffective cough, which led us frequently to examine the lungs carefully, and to suspect that tubercular disease might exist.But I could never detect evidence of anything more than what was subsequently proved by the post mortenm examination, viz., a loadedstate of the bronchial tubes.This condition of lungs, which gave rise to one of the most troublesome and distressing symptoms, must have seriously interfered with their oxygenating function.Thus, during a protracted illness, in which emaciation and waste of tissues were continually going on, the blood would probably become loaded with oily matters, which might be deposited in the liver.At all events, it is in such circumstances that we most frequently meet with fatty liver.But, even assuming that the local disease of the spinal cord was the consequence of some constitutional de- rangement, what was the nature of the local change?Was it the result of inflammation I This again is a question of great practical importance.The few scattered compound granular cells distributed through the softened portion, to- gether with the colour and general appearance, would be considered by many persons as decisive of the inflammatory origin of the change.I will not stop to inquire how far
Prognostic significance of an apoptotic index and apoptosis/proliferation ratio for patients with high-grade astrocytomas
Authors: Hiroko Kuriyama, Kathleen R. Lamborn, Judith R. O'Fallon, N. Iturria, Thomas Sebo, Paul L. Schaefer, Bernd W. Scheithauer, Jan C. Buckner, Nagato Kuriyama, Robert B. Jenkins, Mark A. Israel
Journal: Neuro-Oncology (2002)

We evaluated the association of spontaneous apoptosis and an apoptosis/proliferation index with survival to determine the potential of such measures to serve as predictive markers for patients with glioblastoma multiforme (GBM).We examined the extent of spontaneous apoptosis in tumors from newly diagnosed patients, 75 with GBM and 21 with anaplastic astrocytoma, who were entered on treatment protocols of the North Central Cancer Treatment Group.In the group of GBM patients, those with a higher apoptotic index tended to live longer (P = 0.04; Cox proportional hazards model including performance score, age, and extent of resection in a multivariate model).We found that the apoptotic index values for anaplastic astrocytoma patients tended to be lower than those in the GBM patients, although with small sample sizes, the result was not statistically signi cant
Hope
Authors: JOHN MCCLENAHAN
Journal: Annals of Internal Medicine (1964)

Editorials1 May 1964HopeJOHN MCCLENAHAN, M.D., F.A.C.P.JOHN MCCLENAHAN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-5-928 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThough statistics on the subject are meager and contradictory, it seems likely that during the course of a day's work a radiologist comes upon as many sad surprises as any other doctor or any other man. This is partly due to the great range and depth of his medium and partly to its speed, which permits an observer to view vast panoramas in minutes without ever leaving his chair. Often he is cheered by what he sees, but on the whole the picture is a somber one, and from time to time an aging X-ray man may wonder if discovery...Reference1. FRANKL VE: Man's Search for Meaning, Washington Square, New York, 1963. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1964Volume 60, Issue 5Page: 928-930KeywordsAgingRadiologists Issue Published: 1 May 1964 PDF DownloadLoading ...
Urokinase study
Authors: J. G. Sharnoff
Journal: JAMA (1968)

<h3>To the Editor:—</h3> My state of incredulity upon reading the report by Deverell and Ferguson of "An Unusual Case of Sciatic Nerve Paralysis" (<b>205</b>:699, 1968) propelled me to search the literature. This was occasioned by the incidental reference to the administration of a tetanus toxoid booster one week prior to the onset of symptoms. Edsall et al (<b>202</b>:17, 1967) discussed at length many of the problems related to the use of this agent. Blumstein and Kreithen (<b>198</b>:1030, 1966) reported what is believed to be the first recorded reaction of this type. J. L. Garvey (<i>Postgrad Med</i><b>13</b>:210, 1953) dealt extensively with the various aspects of this problem. R. A. Cooke (<i>JAMA</i><b>114</b>:1854, 1940) attempt to explain why such reactions occur. It is my feeling that the case reported, might fall into one of these brackets. If this communication serves no more than to call attention
Medical Economics and Miscellany
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal