tbuckley/cabot-search huggingface dataset:
The quality of perinatal care in small rural hospitals
Authors: H. A. Hein
Journal: JAMA (1978)

Iowa birth and mortality statistics were reviewed to ascertain the outcome of perinatal care provided in hospitals with different-sized obstetric services. Although the data do not resolve the issue of the minimum number of deliveries necessary to ensure quality perinatal services, they do suggest that hospitals with small maternity services (fewer than 500 deliveries per year) can achieve acceptable perinatal outcomes when appropriate high-risk screening and prenatal referral occur. (<i>JAMA</i>240:2070-2072, 1978)
Lost in Translation
Authors: Mark Saxena
Journal: Annals of Internal Medicine (2009)

On Being a Doctor17 March 2009Lost in TranslationMark Saxena, MDMark Saxena, MDFrom the University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, NJ 08903.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-150-6-200903170-00013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Marta walked into my office, a seasoned veteran. She had been getting monthly international normalized ratio checks, annual eye exams, and quarterly hemoglobin A1c tests for years. On my first day as an intern, she looked at me skeptically and said, “Doctor Sa-sss-ayna?” I was the new doctor with a funny name but also the one who was about to surprise her. For the Spanish-speaking patients in our residency office, we use local college students formally trained as Spanish interpreters to translate. I asked Marta, “Do you prefer to speak in English or Spanish?” She said “Spanish,” and as I ... Author, Article, and Disclosure InformationAffiliations: From the University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, NJ 08903.Corresponding Author: Mark Saxena, MD, University of Medicine and Dentistry of New Jersey–Robert Wood Johnson Medical School, 1 Robert Wood Johnson Place, MEB 486, PO Box 19, New Brunswick, NJ 08903; e-mail, [email protected]com. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited by„Pamiętam, zdarzyło się to w sobotę rano, około 10”. Fachowe publikacje medyczne oparte na relacjach pacjentów i lekarzy 17 March 2009Volume 150, Issue 6Page: 419-420KeywordsHypercholesterolemiaInternational normalized ratioLower back painMouthPerceptionResidencyScarsStatinsTongueTraumatic injury ePublished: 17 March 2009 Issue Published: 17 March 2009 Copyright & PermissionsCopyright © 2009 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
An Assay for the Detection of Xenoestrogens Based on a Promoter Containing Overlapping EREs
Authors: Charbel Massaad, Robert Barouki
Journal: Environmental Health Perspectives (1999)

Xenoestrogens could be implicated in the decrease of male fertility and in the increased incidence of testicular and breast cancers in humans. To predict their deleterious effects, various in vivo or in vitro tests have been proposed to assay the xenoestrogenic activity. We have designed an assay for the detection of xenoestrogens based on a novel estrogen responsive unit formed by two overlapping estrogen response elements (overEREs). This construct is able to mediate a synergistic activation of transcription by 17ss-estradiol. We have used the overERE unit to assay the estrogenic activity of synthetic compounds, mostly organochlorine compounds. By using the overERE construct, we were able to detect the estrogenic activity of compounds at concentrations 10- to 100-fold lower than a single ERE (i.e., we detected the estrogenic effect of endosulfan at a concentration of 10(-5) M with ERE, whereas the overERE unit allowed us to detect a significant estrogenic activity of endosulfan at a lower concentration (10(-6) M). Some compounds did not exhibit any estrogenic activity when tested with a classical ERE, whereas they were potent xenoestrogens when the overERE was used (i.e., Betanal). The assays we have developed are very sensitive and can be performed quickly. Moreover, because the promoter that we used contains only an overlapping ERE as a regulatory unit, the interference of the tested molecules with other regulatory pathways can be avoided.
Involvement of the Glycoproteic Ib-V-IX Complex in Nickel-Induced Platelet Activation
Authors: Silvia Riondino, Fabio Maria Pulcinelli, Pasquale Pignatelli, Pier Paolo Gazzaniga
Journal: Environmental Health Perspectives (2001)

We studied the effect of nickel ions on platelet function because hypernickelemia has been found in patients with acute myocardial infarction. We previously demonstrated that nickel can activate an intracellular pathway leading to cytoskeleton reorganization consequent to tyrosine phosphorylation of p60(src) in human platelets independently of integrin alpha-IIb-beta(3). Moreover, in von Willebrand factor-stimulated platelets, the tyrosine phosphorylation of pp60(c-src) is closely associated with the activation of phosphatidylinositol 3-kinase (PIK), and two adhesion receptors, glycoprotein (Gp)Ib and GpIIb/IIIa(alpha-IIb-beta(3)), are involved. In our study, 1 and 5 mM nickel in the presence of fibrinogen induced platelet aggregation (independently of protein kinase C activation) and secretion. The pretreatment with a PIK inhibitor, wortmannin, strongly decreased nickel-induced platelet aggregation. Platelet treatment with mocarhagin, a cobra venom metalloproteinase that cleaves GpIba, significantly reduced aggregation induced by 5 mM without affecting the response to other agonists such as adenosine diphosphate (ADP). Moreover, nickel caused PIK translocation to the cytoskeleton. Taken together, these observations suggest a partial involvement of both integrins alpha-IIb-beta(3) and GpIb-V-IX complex in Ni(2+)-induced platelet activation.
PM-10 * GENETICALLY ENGINEERED MOUSE MODELS OF CHOROID PLEXUS TUMORS
Authors: J. Wang, D. Merino, B. Murphy, G. Dhall, E. Kiehna, A. Judkins, D. Ellison, C. Eberhart, S. Vandenberg, D. Malkin, R. Gilbertson, M. Roussel, R. Wechsler-Reya
Journal: Neuro-Oncology (2015)
Browning Reaction Systems as Sources of Mutagens and Antimutagens
Authors: William D. Powrie, Chiu H. Wu, V. Paul Molund
Journal: Environmental Health Perspectives (1986)

Heated food systems contain hundreds of chemical compounds, some being mutagenic and others being antimutagenic. Studies have indicated that foods exposed to drying, frying, roasting, baking, and broiling conditions possess net mutagenic activity as assessed by the Ames/Salmonella/microsome mutagenicity test and the chromosome aberration assay with Chinese hamster ovary (CHO) cells. With the above-mentioned heat treatment of food, nonenzymic browning reactions are generally proceeding at rapid rates and are involved in the development of mutagens. Caramelization and Maillard reactions are two important pathways in the nonenzymic browning of food and are responsible for the formation of volatile aromatic compounds, intermediate nonvolatile compounds, and brown pigments called melanoidins. Heated sugar-amino acid mixtures possessed mutagenic activities which have been assessed by short-term bioassays. Purified Maillard and caramelization reaction products such as reductones, dicarbonyls, pyrazines, and furan derivatives have exhibited mutagenicity and clastogenicity. The water-insoluble fraction (WIF) of instant coffee and a model-system melanoidin (MSM) have been shown to inhibit the mutagenicity of known carcinogens--aflatoxin B1 (AFB1), N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), and benzo(a)pyrene (BP)--in aqueous dispersion. WIF and MSM were found to be effective binding agents for the carcinogens.
Plants as Bioassay Systems for Monitoring Atmospheric Pollutants
Authors: William A. Feder
Journal: Environmental Health Perspectives (1978)

Plant species act as natural bioindicators of atmospheric pollutants. Plants can be used as bioassay systems for monitoring atmospheric pollutants. Plant injury symptoms, altered growth and reproductive pattern, changes in yield and/or productivity, and changes in species distribution can be used singly or in combination as monitoring devices. The results must be accepted as semiquantitative, but within that constraint, air quality can be sufficiently well defined to enable the setting of air quality standards. Genetic variability of higher plant species has yielded cultivars which display a range of tolerance to gaseous and particulate atmospheric pollutants. Asexual propagation of these cultivars provides pollutant-sensitive and pollutant-tolerant plant material which can be grown on selected sites for observation. Gymnosperm and Angiosperm species as well as species of lichens and mosses have been used to establish field monitoring networks in Europe, Canada, and the United States. White pine, shade tobacco, mosses, and lichens have proven particularly useful as bioassay tools. Pollen from pollutant-sensitive and pollutant-tolerant plant cultivars has also been used as a sensitive laboratory bioassay tool for studying air quality. Epiphytic mosses are particularly efficient as monitors of particulate pollutants, especially heavy metals, some of which may act as chemical mutagens. The cost, complexity, and lack of reliability of instrumented systems for air quality monitoring make imperative the need to develop successful plant bioassay systems for monitoring air quality.
Progress of Cholera.
Journal: JAMA (1883)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Respiratory Physiology of the Fetus and Newborn Infant
Authors: L. S. James, K. Adamsons
Journal: New England Journal of Medicine (1964)

A SURGE of interest in physiologic events accompanying labor, delivery and the newborn infant's adaptation to his new environment has taken place over the past twenty-five years. Many factors account for this, and it is difficult to place them in order of sequence or priority. Perhaps the most important is the pioneering work of Sir Joseph Barcroft. This has been and continues to be a great source of inspiration, arousing the curiosity of physiologist and clinician alike. At the same time infant mortality during the first seven days of life has remained high despite the advent of antibiotics and a . . .
Radiology '87: Forty-Fifth Annual Congress and Exhibition of the British Institute of Radiology
Journal: JNCI Journal of the National Cancer Institute (1986)

Journal Article Radiology '87: Forty-Fifth Annual Congress and Exhibition of the British Institute of Radiology Get access JNCI: Journal of the National Cancer Institute, Volume 77, Issue 5, November 1986, Page 1173, https://doi.org/10.1093/jnci/77.5.1173-e Published: 01 November 1986
Diet and heartburn
Authors: B. Chernow
Journal: JAMA (1979)

SYMPTOMATIC gastroesophageal reflux (heartburn) is a ubiquitous postprandial complaint. Although usually a recurring complaint, it can be transient (as in the third trimester of pregnancy) or persistent and progressive (as in progressive systemic sclerosis). Regardless of frequency, gastroesophageal reflux produces annoying symptoms for which medical attention is sought. A characteristic feature of heartburn is its relation to food ingestion. Thus, medical advice concerning antireflux dietary adjustments is appropriate. Although no specific smooth muscle sphincter is demonstrable anatomically at the esophagogastric junction, a physiological high-pressure zone exists in this region to prevent regurgitation of acid-peptic stomach contents into the esophagus. In the normal human esophagus, this lower esophageal sphincter (LES) exerts a squeezing pressure of approximately 15 to 20 mm Hg greater than that within the stomach. Failure to maintain this normal pressure barrier results in sphincter incompetence and creates the potential for gastroesophageal reflux.<sup>1</sup> <h3>Effects of Foods on the</h3>
<i>Young Endeavour</i>
Authors: Henry R. Viets
Journal: New England Journal of Medicine (1959)

MEDICAL students throughout the ages have made a surprising number of discoveries that have markedly affected medicine and in some cases industry. More rarely, by putting an old concept in a new form, they have pointed the way to the instigation of productive research, either by the author or by others. One of the classic examples is an incident in the life of Humphrey Davy, a nineteen-year-old medical student apprenticed to a doctor in Penzance, England. When a French ship was wrecked on the coast, Davy obtained some syringes from a medical chest washed ashore. With these he made a . . .
MADRID
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reporting the results of human immunodeficiency virus testing
Authors: A. S. Benenson
Journal: JAMA (1989)

We conducted a pilot study of potential sources of incorrect laboratory reports of human immunodeficiency virus type 1 testing using blind proficiency testing. Sets of three serum samples, including one serum sample with negative reactions in antibody tests, one serum sample with positive reactions, and one that gave false-positive results with certain testing kits, were sent as routine patient specimens to testing laboratories. Half the laboratories reported the serum sample positive for human immunodeficiency virus antibodies as "indeterminate"; one laboratory rendered a final positive report without supplemental testing. On the report forms, the actual laboratory results were often obscured and intermingled with information, sometimes incorrect, such as identifying the agent as "HTLV-III" (human T-cell lymphotropic virus type III) and advising that a test with positive results is evidence of exposure to the virus. Many of these reports have the potential to confuse, rather than to enlighten, the requesting physician. (<i>JAMA</i>. 1989;262:3435-3438)
Pediatrics
Authors: Jonathan D. Klein
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An opportunity to oppose: physicians' role in the campaign against tobacco
Authors: L. Sullivan
Journal: JAMA (1990)

Cigarette smoking and other uses of tobacco are the single most important preventable cause of death in our society. Physicians have a responsibility to inform patients of the health consequences of smoking, to assist patients who do not smoke from starting, and to help smokers to kick the habit. Physicians should make use of the prestige and credibility of their medical training and their position in their communities to speak out on the dangers of smoking in every appropriate forum. Recently, I released a report entitled<i>Smoking and Health: A National Status Report</i>.<sup>1</sup>Regrettably, the death rate from tobacco-related disease remains shocking. Each year, smoking kills almost 400 000 Americans; that is more than 1000 persons a day, accounting for greater than one of every six deaths in our country. The number of Americans who die each year of diseases caused by smoking exceeds the number of Americans who
Iron overload facilitates hepatic fibrosis in the rat alcohol/low-dose carbon tetrachloride model
Authors: M MACKINNON
Journal: Hepatology (1995)

The role of iron deposition in initiating hepatic fibrosis in iron overload disorders is not clearly established, and it is becoming increasingly recognized that iron may be interacting with other potential liver-damaging agents. The authors therefore examined the interplay of iron and alcohol in rats administered subtoxic doses of carbon tetrachloride (CCl4) vapor at 20 ppm in customized chambers. At birth, the offspring of seven pregnant Porton rats were divided into two groups: one group was fed a normal rat chow diet and the other a diet supplemented with 3% (w/w) carbonyl iron for 10 weeks after weaning. In this latter group, the mothers were fed an iron supplement while breastfeeding. At 10 weeks, the animals from the first group (normal chow) were divided into two groups of six animals and fed a Lieber-DeCarli liquid diet with daily exposure to CCl4 vapor: group 1, liquid diet + CCl;group 2, liquid diet + alcohol 150 kcal/l + CCl4. The animals from the second iron-supplemented group were divided into two groups of six animals and fed a liquid diet with 3% (w/v) carbonyl iron and exposed to CCl4 vapor for 10 weeks: group 3, liquid diet + iron + CCl4;group 4, liquid diet + iron + alcohol supplement + CCl4. Two animals from each group of six had a liver biopsy at 4, 6, and 8 weeks, and all animals were killed after 10 weeks of CCl4 exposure. After the first 10-week iron loading period, the rats fed the carbonyl iron-supplemented diet had a 10-fold elevation in hepatic iron concentration. In the second 10-week (CCl4 exposure) period, fibrosis was scored on a four-point scale in each liver biopsy and in all animals at 10 weeks. At 10 weeks, the animals exposed to iron and alcohol in addition to CCl4 all had an established or developing cirrhosis with the development of fibrosis apparent at 4 weeks. Animals in the other groups had markedly less fibrosis, with none seen in the control group up to 10 weeks. Thus, the addition of iron to alcohol facilitates the development of fibrosis in animals exposed to subtoxic doses of CCl4 vapor. This model should allow a more detailed analysis of the mechanism(s) underlying this process. (HEPATOLOGY 1995; 21:1083–1088.)
Effect of Cyproheptadine on the Anaphylactoid Reaction and Localization of Certain Calciphylactic Syndromes
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Note from the editors: Polio – good news and bad news
Authors: None Eurosurveillance editorial team
Journal: Eurosurveillance (2014)

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Testimonial Corrected.
Authors: J. H. Davisson
Journal: JAMA (1898)

Los Angeles, Cal., May 18, 1898. <h3>To the Editor:</h3> —In a forty page booklet entitled, "The Present Status of Diphtheria Antitoxin Serum," issued in large editions by H. K. Mulford &amp; Co., of Philadelphia and Chicago, on page 31 appears a testimonial in which is a wilful change of name of the firm mentioned, which alleged testimonial reads as follows: "California State Board of Health. The antitoxin used in California is made in this country, and after considerable investigation and trials of the German and French preparations, we are giving our preference to the American production... The antitoxin now used by the Board is that of H. K. Mulford Company,<sup>1</sup>Philadelphia, Pa. The American product is put up in better form for transportation and handling, which is of itself an important item. The concentrated 'Extra Potent' (500 units to each c.c.) is the best.—J. H. Davisson, Los Angeles, Secretary