tbuckley/cabot-search huggingface dataset:
Monoethylglycinexylidide (MEGX) and lidocaine (LIDO) determination after oral LIDO administration to acute hepatitis and cirrhotic patients Liver Unit. Hospital de Gastroenterolog�a B. Udaondo; ININFA-CONICET. Buenos Aires, Argentina
Journal: Hepatology (1995)

The activation of host defense mechanisms has been shown to cause a depression in hepatic cytochrome P450-mediated metabolism in rodents and humans. In a previous study, it was demonstrated that the Gram-positive bacteria Listeria monocytogenes causes a down-regulation of hepatic cytochrome P450 and related substrate metabolism as a result of a pretranslational depression of apoprotein synthesis. The objectives of this study were to determine whether the effect of listeria on hepatocyte cytochrome P450 involves hepatic nonparenchymal cells and whether the hemolysin, secreted only by hemolytic forms of the bacteria, plays any part in mediating this effect. Total cytochrome P450 levels as well as ethoxyresorufin-O-dealkylase (EROD) and benzyloxyresorufin-O-dealkylase (BROD) activities were significantly reduced in hepatic microsomes isolated from mice infected in vivo for 48 h with 15U listeria, whereas the same dose of the avirulent non-hemolytic M3D strain had no effect. Listeria (15U) significantly depressed hepatocyte EROD and BROD activities after 24 h incubations with liver cell cultures containing hepatocytes and nonparenchymal cells, as the result of both a direct effect on the hepatocyte and an interaction of listeria with hepatic nonparenchymal cells. The M3D strain of listeria had no effect on cytochrome P-450-mediated metabolism in isolated cells, confirming that hemolysin is an essential component of the mechanism responsible for the down-regulation of cytochrome P450 during listeria infections.
Fiction
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Susceptibility to Infections and Immune Status in Inuit Infants Exposed to Organochlorines
Authors: Eric Dewailly, Pierre Ayotte, Suzanne Bruneau, Suzanne Gingras, Marthe Belles-Isles, Raynald Roy
Journal: Environmental Health Perspectives (2000)

We investigated whether organochlorine exposure is associated with the incidence of infectious diseases in Inuit infants from Nunavik (Arctic Quebec, Canada). We compiled the number of infectious disease episodes during the first year of life for 98 breast-fed and 73 bottle-fed infants. Concentrations of organochlorines were measured in early breast milk samples and used as surrogates to prenatal exposure levels. Immune system parameters were determined in venous blood samples collected from infants at 3, 7, and 12 months of age. Otitis media was the most frequent disease, with 80. 0% of breast-fed and 81.3% of bottle-fed infants experiencing at least one episode during the first year of life. During the second follow-up period, the risk of otitis media increased with prenatal exposure to p,p'-DDE, hexachlorobenzene, and dieldrin. The relative risk (RR) for 4- to 7-month-old infants in the highest tertile of p, p'-DDE exposure as compared to infants in the lowest tertile was 1. 87 [95% confidence interval (CI), 1.07-3.26]. The RR of otitis media over the entire first year of life also increased with prenatal exposure to p,p'-DDE (RR, 1.52; CI, 1.05-2.22) and hexachlorobenzene (RR, 1.49; CI, 1.10-2.03). Furthermore, the RR of recurrent otitis media ( [Greater/equal to] 3 episodes) increased with prenatal exposure to these compounds. No clinically relevant differences were noted between breast-fed and bottle-fed infants with regard to immunologic parameters, and prenatal organochlorine exposure was not associated with immunologic parameters. We conclude that prenatal organochlorine exposure could be a risk factor for acute otitis media in Inuit infants.
Coracoclavicular Joint
Authors: F. J. S. Hall
Journal: BMJ (1950)

Case 8.-A fishmonger aged 35 first attended hospital on November 5, 1949, with a swelling of the right forefinger.There was some axillary adenitis.On October 31 his forefinger was painful and seemed " inflamed " (red) on the dorsum of the distal phalanx.There was no noticeable skin trauma.The next day there was some improvement, which continued until November 4, when the right forefinger became very painful, red, and swollen in appearance.He had kept at his work all this time.The usual course of 300,000 units of procaine peni- cillin with local antiphlogistine was given for five days, when the condition completely cleared.
Statistical Overkill
Authors: Rudolph H. De Jong
Journal: JAMA (1970)

Many times we read that treatment A differs<i>significantly</i>from treatment B, as determined by a certain statistical test. Is treatment A therefore better (or worse as the case may be) than treatment B? Often—but not always. Take for instance the case of Hypopressin, a new drug to reduce blood pressure. In clinical tests at a prestigious university hospital it decreases average systolic pressure by 2.3 mm Hg as compared with a placebo. This, the authors assure us, is a highly significant (P&lt;0.01) reduction. No question about it, Hypopressin lowers the average blood pressure—but oh how feebly. Would you use it to treat a patient with malignant hypertension? No, for the drug's effect is therapeutically trifling, little better than the placebo. Statistically significant it is, to be sure. But biologically important? Hardly, I daresay. The opposite can also happen where, either from large sample-to-sample variation or from a shortage of
Environmental racism: time to tackle social injustice
Authors: None The Lancet Planetary Health
Journal: The Lancet Planetary Health (2018)

Among the injustices faced by racial and ethnic minority communities, one aspect that is frequently overlooked is the effect of discrimination on the environment that the community is based in. Whether due to targeted prejudice or resulting from ingrained institutional bias, the effects are too often the same: minority residents end up living in more polluted areas with less access to green space than their majority peers.
Das Bronchuscarcinom.
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Neuron Specific Enolase, A Clinically Useful Marker For Neurons And Neuroendocrine Cells
Authors: P. Marangos
Journal: Annual Review of Neuroscience (1987)

The brain's default mode network consists of discrete, bilateral and symmetrical cortical areas, in the medial and lateral parietal, medial prefrontal, and medial and lateral temporal cortices of the human, nonhuman primate, cat, and rodent brains. Its ...Read More
Hepatoma: Review of 43 Cases with Comments on Syphilis as an Etiologic Factor
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE COLLECTIVE INVESTIGATION.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A twin study of the effects of the Vietnam War on posttraumatic stress disorder
Authors: J. Goldberg
Journal: JAMA (1990)

This study evaluates the impact of military service during the Vietnam era (1965 to 1975) on posttraumatic stress disorder using a sample of 2092 male-male, monozygotic, veteran twin pairs. Data were collected in 1987 using mail and telephone interviews. In 715 monozygotic twin pairs who were discordant for military service in southeast Asia (SEA), posttraumatic stress disorder was found to be strongly associated with military service in SEA. The prevalence of posttraumatic stress disorder was 16.8% in twins who served in SEA compared with 5.0% in co-twins who did not serve in SEA. There was a ninefold increase in the prevalence of posttraumatic stress disorder (95% confidence interval, 4.8 to 17.6), comparing twins who experienced high levels of combat with their co-twin who did not serve in SEA. Our results demonstrate that nearly 15 years following the end of the Vietnam War, there remains a substantially increased prevalence of posttraumatic stress disorder among veterans who served in SEA. (<i>JAMA</i>. 1990;263:1227-1232)
Miscellany
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Early Telomere Shortening and Genomic Instability in Tubo-Ovarian Preneoplastic Lesions—Response
Authors: Gautier Chene, Andrei Tchirkov, Frederique Penault-Llorca
Journal: Clinical Cancer Research (2013)

Telomere length shortening appears to be one of the earliest in the initiation of epithelial carcinogenesis. It may lead to further activation of the DNA damage cellular response pathways. For instance, telomere instability occurs in most cases of early and preinvasive stage of bladder, prostate, cervix, colon, esophageal, or breast cancer (1, 2). In our study (1), preneoplastic lesions (especially serous tubal intraepithelial carcinoma or STIC) have showed the shortest telomeres, in agreement with the results of Kuhn and colleagues (3).To investigate whether age interacted with telomere length evaluation in our study, we compared the average age in different groups. The average age was strictly the same (50.8 years) in control and dysplasia groups (P = 0.95, NS), whereas the mean telomere length was significantly lower in dysplasia patients than in controls, 0.63 versus 1.76 respectively (P < 10−7). In the same way, the average age of patients was not different in STIC and cancer groups (59.5 vs. 61 years; P = 0.62, NS), but the telomere length was much shorter in STIC group than in cancer group, 0.24 versus 1.02 (P < 10−5). Thus, it seems unlikely that age had any impact on differences in telomere length found in our study.Unfortunately, we do not have the BRCA status of cancer group. Of note, telomere length in our study was measured in ovarian or tubal tissue and not in a surrogate tissue as in the study by Martinez-Delgado and colleagues (4) who found shorter telomeres in blood leukocytes of BRCA1/2 mutation carriers among the patients with ovarian cancer. In our study, the relative increase in telomere length in cancer cases compared with dysplasia cases can be most likely explained by the reactivation of telomerase in cancer cells, which leads to an increase in telomere length by regenerating telomeric DNA. This effect cannot be seen in nontumor tissues like normal peripheral blood cells. The effect of telomerase is direct and probably stronger than the impact of BRCA1/2 status on telomere length.See the original Letter to the Editor, p. 5254No potential conflicts of interest were disclosed.
Die Stammganglien und die extrapyramidal-motorischen Syndrome.
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medicine in History
Authors: J.R. E.
Journal: Annals of Internal Medicine (1970)

Editorials1 April 1970Medicine in HistoryJ.R. E., E.J. H.J.R. E.Search for more papers by this author, E.J. H.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-72-4-593_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPresident Franklin Delano Roosevelt died on April 12, 1945, 25 years ago this month. In his fourth term of the Presidency, he died at a time when he was carrying tremendous responsibilities. He had led the nation through most of the Second World War. He had attended a series of conferences of Allied leaders culminating in the crucial conference at Yalta in February 1945. To some observers, including Winston Churchill, his health appeared to be failing. What was the degree of his disability, and what was its effect on history?We are fortunate to be able to publish in this...Reference1. L'Etang H: The Pathology of Leadership. London, William Heinemann Medical Books, 1969, p. 218 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: J.R. E.; E.J. H. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe untold neurological disease of Franklin Delano Roosevelt (1882–1945)Chapter 1 Antitumor Alkaloids 1 April 1970Volume 72, Issue 4 Page: 593-593 Keywords Disabilities History of medicine ePublished: 1 December 2008 Issue Published: 1 April 1970 PDF downloadLoading ...
Prognostic Impact of Interval Breast Cancer Detection in Women with pT1aN0M0 Breast Cancer with HER2-positive Status: Results from a Multicenter Population-based Cancer Registry Study
Authors: D. Boggiani, A. Sikokis, A. Rimanti, B. Pellegrino, E.M. Silini, N. Campanini, E. Barbieri, L. Cortesi, M. Panebianco, R. Porzio, A. Frassoldati, P. Sgargi, F. Falcini, M. Michiara, A. Musolino
Journal: Annals of Oncology (2016)
Quest for the grave of Dr Nathaniel Chapman
Authors: F. B. Wagner
Journal: JAMA (1985)

AT THE November 1984 meeting of the Francis C. Wood Institute of the History of Medicine in the College of Physicians of Philadelphia, Dr Wood expressed interest in finding the grave of Dr Nathaniel Chapman. The latter had been the first president of the AMA in 1847.<sup>1</sup>As professor of the Practice of Medicine at the University of Pennsylvania, Philadelphia, founder of the Philadelphia Medical Institute, president of the American Philosophical Society, and first editor of what became the<i>American Journal of the Medical Sciences</i>, he exerted a profound influence on the medical education and clinical practice of his era.<sup>2-5</sup>By coincidence, Dr Wood took care of a patient by the name of Ardenia Chapman from 1947 until her death in 1975 (<i>Philadelphia Inquirer</i>, Feb 5, 1975, p 8-B). She was a lineal descendent who remembered that Dr Chapman had been buried in St Stephen's Episcopal Church at
A phase 1b study of lenvatinib plus pembrolizumab in unresectable hepatocellular carcinoma
Authors: Richard Finn, Masafumi Ikeda, Andrew Zhu, Max W. Sung, Ari D. Baron, Masatoshi Kudo, Takuji Okusaka, Masahiro Kobayashi, Hiromitsu Kumada, Shuichi Kaneko, Marc Pracht, Konstantin Mamontov, Tim Meyer, Kalgi Mody, Tomoki Kubota, Corina E. Dutcus, Kenichi Saito, Abby B. Siegel, Leonid Dubrovsky, Josep M. Llovet
Journal: Journal of Hepatology (2020)
Hepatitis C and G co-infection: Response to interferon therapy and quantitative changes in serum HGV-RNA.
Authors: J McHutchison
Journal: Hepatology (1997)

Hepatitis G virus (HGV), a positive sense RNA virus, is distantly related to hepatitis C virus (HCV): its genetic organization and identity are consistent with the Flaviviridae family. Coinfection with HGV occurs in 10% to 20% of HCV-infected subjects. These similarities raise two theoretical questions. First, could HGV coinfection play any role in the response of HCV to antiviral therapy and second, would this coinfected population have changes in serum HGV-RNA induced by interferon. To address these questions, 98 patients with documented chronic HCV underwent interferon therapy (3 million units three times a week) for 6 months. Response to therapy was categorized using standard biochemical criteria. Changes in HGV-RNA levels were evaluated before, during, and after interferon therapy by a quantitative branched DNA amplification research-based assay. Eleven of 98 (11%) patients with HCV infection had detectable serum HGV-RNA. There was no difference between the groups (HGV+ vs. HGV-) when baseline alanine aminotransferase (ALT) values, HCV-RNA levels, HCV genotype, histological severity, or other demographic features were analyzed. Interferon response was similar in both groups and HGV was not associated with outcome following therapy. Antiviral therapy appeared to induce a reduction in HGV-RNA load in five of nine patients coinfected with HCV serially tested. In two patients, the fall in serum HGV-RNA correlated with biochemical response, independent of changes in HCV-RNA. These observations indicate that a larger study of an HGV population is required to more clearly define the relationship between HCV and HGV coinfection and their response to antiviral therapy. (Hepatology 1997 Nov;26(5):1322-7)
Fourth Annual Symposium on Advances in Cancer Treatment Research
Journal: JNCI Journal of the National Cancer Institute (1979)

Journal Article Fourth Annual Symposium on Advances in Cancer Treatment Research Get access JNCI: Journal of the National Cancer Institute, Volume 62, Issue 1, January 1979, Page 213, https://doi.org/10.1093/jnci/62.1.213d Published: 01 January 1979
Phymosis.
Authors: B. Storch
Journal: JAMA (1891)

<h3>To the Editor:</h3> —Page 271 in No. 8 ofThe Journalcontains an article on " Painless Circumcision" by Dr. G. W. Overall, with which I was much pleased. It is a great step in advance of the old method of giving chloroform, which several times in my practice endangered the life of the little patient. Since then I have to a certain extent followed the method of Dr. Overall. That is, I have used a 20 or 30 per cent, solution of cocaine and injected 10 or 15 drops with a blunt pointed glass syringe into the preputial orifice, pressing the prepuce tightly around the end so as to retain the fluid, after removing the syringe. I churned the fluid cocaine so as to come in contact with the entire mucous membrane for ten or fifteen minutes. I at the same time sprayed over the entire integument where the circumcision