tbuckley/cabot-search huggingface dataset:
Abstract 424: Genomic instability changes of circulating tumor DNA reflect the responses to chemotherapy or targeted therapy in advanced gastric cancer
Authors: Zuhua Chen, Cheng Zhang, Beifang Li, Yunyun Niu, Limeng Chen, Mengqi Zhang, Jing Yang, Sijia Lu, Jing Gao, Lin Shen
Journal: Cancer Research (2019)

Abstract Background: Gastric cancer was characterized by frequent somatic copy number alterations and high genomic instability, yet the significance of genomic instability and its changes implicated by drug treatment in advanced gastric cancer (AGC) remain unclear. In this study, we investigated genomic instability changes of circulating tumor DNA (ctDNA). Methods: A total of 101 plasmas and paired blood cells from 26 patients with AGC before (N=26) and after (N=75) treatment were prospectively collected. Plasma ctDNA was separated and assessed for copy number variations (CNV) by whole genome sequencing (WGS), and we assessed the correlation between genomic indexes and therapeutic response. Results: Genomic instability with diverse patterns was observed in 20 of 26 patients (77%) prior to drug treatment. For patients with high (N=20) level genomic instability prior to drug treatment, the response rate (55%, 11/20) was significantly higher than that (17%, 1/6) in patients with low level (N=6) genomic instability (P=0.17). Notably, genomic instability changed with the administration of drugs, which reflected its correlation with therapeutic response. All ctDNAs (94%, 14/15) collected at the time of partial response (PR) after treatment displayed low-genomic instability. However, 52% ctDNAs (13/25) collected at the time of progressive disease (PD) after treatment showed high-level genomic instability. Furthermore, several patterns of CNV were categorized in ctDNAs. CNV pattern after acquiring drug resistance were largely unchanged with respect to CNV baseline patterns. Conclusions: Genomic instability based on ctDNA can be used to predict and monitor therapeutic response in gastric cancer, although validation in larger cohort would be necessary. Citation Format: Zuhua Chen, Cheng Zhang, Beifang Li, Yunyun Niu, Limeng Chen, Mengqi Zhang, Jing Yang, Sijia Lu, Jing Gao, Lin Shen. Genomic instability changes of circulating tumor DNA reflect the responses to chemotherapy or targeted therapy in advanced gastric cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 424.
Manuscripts Approved for JNCI, July 1 to August 1, 1968
Journal: JNCI Journal of the National Cancer Institute (1968)

Journal Article Manuscripts Approved for JNCI, July 1 to August 1, 1968 Get access JNCI: Journal of the National Cancer Institute, Volume 41, Issue 3, September 1968, Pages 825–826, https://doi.org/10.1093/jnci/41.3.825-b Published: 01 September 1968
CANADA
Journal: JAMA (1960)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Zoonoses
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Graduate medical education in the changing environment of medicine
Authors: C. J. Martini
Journal: JAMA (1992)

THE US graduate medical education system has been strongly criticized by policymakers and by private and public agencies for not being responsive to the population's health needs. Comments usually focus on the unwillingness of the accreditation and education systems to generate the proper mix of specialties and to influence a more equitable geographical distribution of physicians. No one disputes the inadequacy of the distribution of medical specialties, particularly in the medical care of underserved populations, but to blame solely the graduate medical education and accreditation systems is to ignore the absence of population-based planning for health services—a governmental responsibility—and the important, though lesser, contributions of other medical education components. Education, accreditation, licensure, certification, and practice, although interrelated, are all directed by different organizations. Changes in only one or two of these components will never be sufficient to solve the health manpower problems of the health care delivery system, which would
The Education of the Patient With Cardiac Disease in the Twenty First Century
Journal: Thorax (1986)

incision, especially after osteotomy of the second rib.'0In view of this a posterolateral approach was preferred for our patient and first rib resection was carried out via this approach without difficulty.Postoperative recovery was uneventful and the cosmetic result was also satisfactory.Payne-James, Walesby Our case illustrates the problems of management of a potentially malignant lesion in a rare and relatively inacces- sible site.We would suggest that the treatment of choice for tuinour of a first rib would be excision via a posterolateral approach.
Effects of Prolonged Administration of Phthalate Ester on the Liver
Authors: A. E. Ganning, U. Brunk, C. Edlund, A. Elhammer, G. Dallner
Journal: Environmental Health Perspectives (1987)

Di(2-ethylhexyl)phthalate (DEHP) was administered to male rats in the diet at concentrations of 2.0, 0.2, and 0.02% for up to 102 weeks. Low doses resulted in moderate increases in certain hepatic enzymes during the initial phase of exposure and in a continuous increase in the activities of these same enzymes throughout the treatment period. An increased level of dolichol and decreased concentration of dolichyl-P were observed. Furthermore, the rate of protein glycosylation diminished. Liver biopsies from patients subjected to hemodialysis demonstrated an increased number of peroxisomes. Phthalate ester seems to interfere with protein turnover, so that the half-life of total mitochondrial and microsomal protein is considerably increased.
Erratum: HTLV-I infection of WE17/10 CD4+ cell line leads to progressive alteration of Ca2+ influx that eventually results in loss of CD7 expression and activation of an antiapoptotic pathway involving AKT and BAD which paves the way for malignant transformation
Authors: H Akl, B M Badran, N El Zein, F Bex, C Sotiriou, K E Willard-Gallo, A Burny, P Martiat
Journal: Leukemia (2009)
Authors’ Reply
Authors: Erica Winnicki, Charles E. McCulloch, Elaine Ku
Journal: Journal of the American Society of Nephrology (2019)

We thank Preka et al. for their comments regarding our analysis using the US Renal Data System to investigate the association between higher versus lower eGFR at dialysis initiation in children and survival.1 We concur that postponing chronic dialysis in children in every clinical setting would be inappropriate and not supported by the current literature, and we do not suggest adoption of such practice based on our study results. We acknowledge there are limitations to the conclusions that can be drawn from our study given its observational nature and the lack of more granular data surrounding the reasons for dialysis initiation. Certainly, a causal relationship between higher eGFR at dialysis initiation in children and increased risk of mortality are not established with such a study design. We also thank the authors for highlighting their recent findings.2 As noted in their letter, in this European cohort of pediatric patients with CKD, no clinical benefit was found to be associated with earlier initiation of dialysis. The fact that no benefit to earlier initiation of dialysis in children has been identified in multiple observational studies,1–3 coupled with the trend toward initiation of dialysis at higher levels of kidney function in children with CKD over time,1,3 raises concerns regarding the recent changes in national practice patterns in the United States. A clinical trial would indeed be informative in this regard. However, we do note that timing of dialysis initiation is one of the areas where the observational evidence has agreed with clinical trial results,4 at least in adults. In the meantime, we agree that many clinical criteria, and certainly not eGFR alone, should be taken into account when deciding whether chronic dialysis therapy should be initiated. Regardless, efforts to increase living kidney donation and pre-emptive kidney transplantation rates should continue to provide children with CKD the best long-term health outcomes. Disclosures None. Funding Dr. Ku is supported by National Institutes of Health (NIH) grant R01 DK115629. Dr. McCulloch is supported by the National Center for Advancing Translational Sciences, NIH, through University of California, San Francisco Clinical and Translational Science Institute (UCSF-CTSI) grant KL2 TR001870.
ACROMEGALY.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MEDICAL EDUCATION IN INDIANA.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Vehicle Smog Emissions: Can We Avoid Afterburners?
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
New Approaches for Detecting and Curtailing Foodborne Microbial Infections
Authors: Joan Stephenson
Journal: JAMA (1997)

HEADLINES of recent foodborne disease outbreaks—strawberries tainted with hepatitis A virus, unpasteurized apple juice contaminated with<i>Escherichia coli</i>0157:H7, raspberries harboring<i>Cyclospora cayetanensis</i>—are doing much to fuel the perception that microbial pathogens are gaining an upper hand. But while it's true that such pathogens are evolving new tricks and exploiting new opportunities, epidemiologists and laboratory scientists are countering with new strategies that promise to revolutionize the detection of infections caused by foodborne microbes. See also pp 1340 and 1344 National surveillance of foodborne diseases at a group of sentinel public laboratories around the nation, sophisticated technologies such as DNA fingerprinting to pinpoint specific bacterial subtypes responsible for an outbreak, and computer networks that link and analyze the findings of far-flung laboratories may soon provide public health experts with an early warning system far beyond what is possible today. Although such efforts have been in progress during the past
THE URIC ACID PROBLEM
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 2995: Thymoquinone attenuates breast cancer cell resistance to paclitaxel via targeting tumor associated stem cell population
Authors: Hanan A. Bashmail, Aliaa A. Alamoudi, Gehan A. Hegazy, Ghada M.A. Agabnoor, Abdulwahab Noorwali, Ahmed M. Al-Abd
Journal: Cancer Research (2019)

Abstract Breast cancer remains the most common type of cancer in females, and remains to be one of the most leading causes of death worldwide. This led to increasing the interest to use adjuvant anti-cancer therapy to improve the efficacy of in-clinical use chemotherapeutic agents. Thymoquinone (TQ) is a naturally occurring bioactive compound which showed cumulative evidences of anticancer properties. Herein, we assessed the potential chemomodulatory effect of TQ as an adjuvant therapy in combination with paclitaxel (PTX) against breast cancer cells. Cytotoxic profiles of TQ alone or in combination with PTX were evaluated in MCF7 and T47D breast cancer cell lines. TQ showed cytotoxic effect against MCF7 and T47D cells with IC50’s of 64.93±14 µM and 165±2 µM, respectively. In MCF7, TQ did not change PTX’s IC50, and the combination index was indicative of antagonism (CI-value = 1.3). Similarly in T47D, combination of TQ with PTX increased PTX’s IC50 from 90±8 nM to 140±20 nM with CI-value of 1.5 indicating antagonism. However, it was found that TQ completely depleted PTX resistant fractions in both cancer cell lines under investigation. Moreover, apoptotic and autophagic cell death due to combination of PTX with TQ were significantly increased in T47D compared to PTX treatment alone by 5.6 and 1.7 folds, respectively. In MCF7, combination of TQ with PTX significantly increased autophagic cell death compared to PTX treatment alone. Furthermore, tumor associated stem cell clone (CD44(+)/CD24(-)/(low) was assessed by flow cytometry in MCF7 and T47D cells. TQ alone significantly decreased CD44+/CD24- tumor associated stem cell clone by 12.4±0.8%. In addition, combination of PTX with TQ further depleted CD44+/CD24- cell clone by 32.3±0.08%. Finally, TQ alone significantly downregulated TWIST-1, and upregulated SNAIL2 gene expression as an evidence to decreased cell resistance to PTX. In conclusion, TQ enhances PTX anticancer profile against breast cancer cells via depleting tumor associated stem cells clone rather than potentiating its direct cell killing effect. Citation Format: Hanan A. Bashmail, Aliaa A. Alamoudi, Gehan A. Hegazy, Ghada M.A. Agabnoor, Abdulwahab Noorwali, Ahmed M. Al-Abd. Thymoquinone attenuates breast cancer cell resistance to paclitaxel via targeting tumor associated stem cell population [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2995.
NIH Consensus Development Conference—Indications for and Risks of Treatment With Fresh Frozen Plasma
Journal: JNCI Journal of the National Cancer Institute (1984)

NIH Consensus Development Conference—Indications for and Risks of Treatment With Fresh Frozen Plasma Get access JNCI: Journal of the National Cancer Institute, Volume 73, Issue 2, August 1984, Page 553, https://doi.org/10.1093/jnci/73.2.553 Published: 01 August 1984
<i>Pneumocystis jirovecii</i>Pneumonia in Renal Transplant Recipients occurring after prophylaxis discontinuation: a case control-study.
Authors: Nathalie De Castro, FranÃ§ois Xu, Raphael Porcher, Juliette Pavie, Jean-Michel Molina, Marie-NoÃ«lle Peraldi
Journal: Clinical Microbiology and Infection (2009)
Abstract 1439: Identification and characterization of neoantigen specific T cells
Authors: Martin S. Naradikian, Leslie Montero, Samantha Hall, Milad Bahmanof, Rukman Thota, Luise Sternberg, Jerome Lane, Zeynep Kosaloglu-Yalcin, Manasa Lanka, Aaron Miller, Bjoern Peters, Ezra Cohen, Stephen Schoenberger
Journal: Cancer Research (2019)

Abstract Neoantigens (NeoAg) offer attractive therapeutic targets for directing a patient’s immune response to the immunogenic subset of mutations expressed exclusively by their cancer cells. Despite the specificity with which NeoAg enable tumor recognition, the majority of approaches for their identification rely on purely predictive methods such as calculating the ability of mutated peptides to bind to a patient’s set of HLA molecules, and have met with limited success in revealing natural targets present on tumor cells. We have developed a novel HLA-agnostic functional approach to NeoAg identification which combines genomic sequencing with bioinformatic analysis to nominate mutations for subsequent functional analysis using patient’s own T cells in an effort to identify natural responses generated under physiologic conditions. Using this, we identified a missense mutation (V205&amp;gt;I) in the ribosomal protein RPS2 that is recognized by CD8+ T cells from tumor-infiltrating lymphocytes (TIL) of a metastatic HPV-16+ Head and Neck Squamous Cell Carcinoma (HNSCC) lesion. We then performed adoptive cellular therapy (ACT) using either unseparated TIL or those enriched for RPS2 V205&amp;gt;I-specific CD8+ T cells and found the latter to be superior in controlling outgrowth of tumor of a PDX cell line generated from this lesion in NSG mice. Finally, we used single-cell transcriptomics to isolate the genes encoding the RPS2-specific TCR and show that it recognizes the mutated peptide bound to HLA-B*07.02 as well as the tumor cell line expressing the RPS2 protein. These results demonstrate that high-affinity NeoAg-specific T cell responses can be identified in cancer patients, that ACT of these cells can control tumor growth, and that the relevant TCR can be isolated for use in TCR engineering-based immunotherapy. Citation Format: Martin S. Naradikian, Leslie Montero, Samantha Hall, Milad Bahmanof, Rukman Thota, Luise Sternberg, Jerome Lane, Zeynep Kosaloglu-Yalcin, Manasa Lanka, Aaron Miller, Bjoern Peters, Ezra Cohen, Stephen Schoenberger. Identification and characterization of neoantigen specific T cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1439.
Crkl is constitutively tyrosine phosphorylated in platelets from chronic myelogenous leukemia patients and inducibly phosphorylated in normal platelets stimulated by thrombopoietin
Authors: A Oda, Y Miyakawa, BJ Druker, A Ishida, K Ozaki, H Ohashi, M Wakui, M Handa, K Watanabe, S Okamoto, Y Ikeda
Journal: Blood (1996)