tbuckley/cabot-search huggingface dataset:
A New Minor Tranquilizer
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ENDOSCOPIC TRANS-PAPILLARY BIOPSY USING A SELF-ASSEMBLED DEVICE: THE “TUNNEL TECHNIQUE”
Authors: B Orlandini, A Tringali, V Perri, I Boškoski, P Familiari, G Costamagna
Journal: Endoscopy (2020)

A 77-year-old patient was referred for cholangitis. CT-scan and MR revealed stenosis of the left intrahepatic duct. ERCP confirmed the stenosis and the “tunnel technique” was applied. A 11.5-Fr biliary dilation catheter was used as “tunnel” for biopsy forceps after cutting the tapered tip, leaving the radiopaque marker as reference point. Once obtained biliary cannulation with a 035-inch guidewire, the catheter was advanced in the left intrahepatic duct, close to the stricture. 7-French biopsy-forceps with 7-mm-wide cups were inserted inside the catheter. Biopsies of the stricture were easily performed. Based on histology in favor of cholangiocarcinoma, hepatic resection was scheduled.
Memories of Sir William Osler
Authors: W. C. Davison
Journal: JAMA (1969)

Sir William Osler loved people, especially children,<sup>1</sup>old people, and medical students. As a result, children, old people, students, physicians, and patients loved him. In addition to being a superb clinician and a magnificent teacher, Osler made everyone with whom he came in contact feel that he was primarily and genuinely interested in that individual. I have met hundreds of his former students in America and England who shared that belief. For example, Thomas B. Futcher, who was supposed to give me an examination in medicine when I transferred from Oxford to the senior class at the Hopkins in 1916, happily chatted about the "Chief" for an hour and then gave me a good grade. John Musser did the same thing when I took the national board examinations on my return from the American Expeditionary Force (AEF) in France in 1919. In fact, passing examinations seemed more dependent on
Recurrent hemoperitoneum reversed by ascorbic acid
Authors: W. L. Cooke
Journal: JAMA (1977)

HEMOPERITONEUM, excluding those episodes resulting from surgically reversible conditions, is usually associated with a fatal outcome.<sup>1-3</sup>Recurrent hemoperitoneum is, therefore, exceedingly rare, and medically reversed recurrent hemoperitoneum has not been reported.<sup>4</sup> In the following account, a patient with multiple episodes of hemoperitoneum appears to have been cured by ascorbic acid therapy. <h3>Report of a Case</h3> A 48-year-old white woman, gravida 2, para 2, was hospitalized in April 1967, complaining of hypermenorrhea for one year and abdominal pain for five weeks. No unusual bleeding had occurred in association with dental extractions or episiotomies during vaginal deliveries. No easy bruisability had been noted, and no relative had experienced unusual bleeding. Her only medication had been aspirin as treatment for intermittent headaches. Examination disclosed minimal pallor and moderate abdominal distention. No angiomas were noted in the skin or mucous membranes. The uterus was enlarged. Hemoglobin level was 10.7 gm/100 ml, and
A Comparison of Two Drugs to Treat Exercise-Induced Asthma
Journal: Annals of Internal Medicine (2000)

Summaries for Patients18 January 2000A Comparison of Two Drugs to Treat Exercise-Induced AsthmaAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-2-200001180-00027 SectionsAboutFull Text ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?In some people, exercise triggers narrowing of the airways (bronchoconstriction), a form of asthma. Previous studies have shown that a relatively new drug, montelukast, protects against exercise-induced asthma. However, it is not known whether montelukast works better than some of the older asthma drugs, such as salmeterol. Montelukast is taken by mouth in the form of a pill once a day. Salmeterol is inhaled from a special spray container twice a day.Why did the researchers do this particular study?The researchers wanted to compare directly the effectiveness ... Author, Article, and Disclosure InformationThe summary below is from the full report titled “Oral Montelukast Compared with Inhaled Salmeterol To Prevent Exercise-Induced Bronchoconstriction. A Randomized, Double-Blind Trial.” It is in the 18 January 1999 issue of Annals of Internal Medicine (volume 131, pages 97-104). The authors are J.M. Edelman, J.A. Turpin, E.A. Bronsky, J. Grossman, J.P. Kemp, A.F. Ghannam, P.T. DeLucca, G.J. Gormley, and D.S. Pearlman, for the Exercise Study Group.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoOral Montelukast Compared with Inhaled Salmeterol To Prevent Exercise-Induced Bronchoconstriction Jonathan M. Edelman , Jennifer A. Turpin , Edwin A. Bronsky , Jay Grossman , James P. Kemp , Asma F. Ghannam , Paul T. DeLucca , Glenn J. Gormley , and David S. Pearlman , for the Exercise Study Group* Metrics Cited byAsthmabehandlung 18 January 2000Volume 132, Issue 2Page: 97KeywordsAdverse reactionsAsthmaBreathingDrugsExerciseMouthPatientsResearch laboratories ePublished: 15 August 2000 Issue Published: 18 January 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.Loading ...
Errors in Table 3 and Table 4
Journal: JAMA Network Open (2020)

Vivian F. Go, PhD; Heidi E. Hutton, PhD; Tran V. Ha, MD; Geetanjali Chander, MD; Carl A. Latkin, PhD; Nguyen V. T. Mai, MPH; Bui X. Quynh, BA; Vu Nguyen, BS; Teerada Sripaipan, MPH; Kathryn E. Lancaster, PhD; Natalie Blackburn, PhD; Rebecca B. Hershow, PhD; David W. Dowdy, PhD; Constantine Frangakis, PhD
Software
Authors: Ben Eiseman
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Corrections to “Pathway level alterations rather than mutations in single genes predict response to HER2-targeted therapies in the neo-ALTTO trial”
Authors: W. Shi, T. Jiang, P. Nuciforo, C. Hatzis, E. Holmes, N. Harbeck, C. Sotiriou, L. Peña, S. Loi, D.D. Rosa, S. Chia, A. Wardley, T. Ueno, J. Rossari, H. Eidtmann, A. Armour, M. Piccart-Gebhart, D.L. Rimm, J. Baselga, L. Pusztai
Journal: Annals of Oncology (2019)

Ann Oncol 2017; 28: 128–135 (doi: 10.1093/annonc/mdw434) In the original article, the disclosure was incomplete. This has now been updated to add the statement for J. Baselga: JB has performed consulting and/or advisory work for Grail, Roche, Lilly, Novartis. He has stock or other ownership interests in Grail. Pathway level alterations rather than mutations in single genes predict response to HER2-targeted therapies in the neo-ALTTO trialAnnals of OncologyVol. 28Issue 1PreviewWe performed whole-exome sequencing of pretreatment biopsies and examined whether genome-wide metrics of overall mutational load, clonal heterogeneity or alterations at variant, gene, and pathway levels are associated with treatment response and survival. Full-Text PDF Open Archive
Citations
Authors: Albert D. Lasker
Journal: JAMA (1974)

<h3>John Charnley, DSc, FRCS</h3> Professor Charnley receives the Albert Lasker Clinical Medical Research Award for his original, innovative concepts for total prosthetic joint replacement, developed during the 1950s, which have had a major impact on improving the treatment and rehabilitation of patients with crippling joint diseases—especially arthritis. Combining his talents as an orthopedic surgeon and biomedical engineer, Professor Charnley conducted original laboratory and clinical research in joint lubrication and the biomedical characteristics of joint opposition. The investigations led to the development of a revolutionary design of a total hip joint replacement and the introduction of the use of methyl methacrylate as a plastic cement to firmly affix the prosthetic components to the bone. Although the pioneering work on joint prosthetics going back to 1908 cannot be ignored, the present advances were made possible by Professor Charnley's unique concepts. The techniques and concepts that he introduced in 1961 have given patients
Birth
Authors: Kelly E. Largent
Journal: Annals of Internal Medicine (2019)

Ad Libitum5 February 2019BirthKelly E. Largent, MDKelly E. Largent, MDBiltmore Medical Associates, Asheville, North Carolina (K.E.L.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M18-1545 Audio Reading - “Birth” Audio. Virginia L. Hood, MD, reads "Birth," by K.E. Largent. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Birth begins through broken shellsin driven pecks at one's originsor the urgent squeezing thrust fromwombs outgrown as perfect home.Who knows all that it takesto ignite the muscled pathor awaken swaddled wingsand stir their fluttering?Who warns of what awaits?the blinding light, the shattering noisethe bracing air new lungs must takeand boundless space unfolding limbsfall into, flailing.Warm welcome and soft murmurscannot change arrival's truth—the first proof of longed-for lifeis its fierce wailing. Author, Article, and Disclosure InformationAffiliations: Biltmore Medical Associates, Asheville, North Carolina (K.E.L.)Current Author Address: Kelly E. Largent, MD; e-mail, [email protected]edu. PreviousarticleNextarticle Advertisement Audio Reading - “Birth” Audio. Virginia L. Hood, MD, reads "Birth," by K.E. Largent. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 5 February 2019Volume 170, Issue 3Page: 163KeywordsBirthFallsLungsMuscular dystrophiesUterus ePublished: 5 February 2019 Issue Published: 5 February 2019 Copyright & PermissionsCopyright © 2019 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Predictive value of ALT levels for histologic findings in chronic hepatitis C: A European collaborative study
Authors: P Pradat
Journal: Hepatology (2002)

The aim of this retrospective study was to determine the predictive value of alanine aminotransferase (ALT) levels for histologic findings in patients with chronic hepatitis C virus (HCV) infection. Data on 864 HCV RNA–positive patients were collected. ALT values were obtained at the time of biopsy (before treatment), and normal ALT values were defined as normal values obtained at serial evaluations during a 6-month period. Histologic results were scored using the METAVIR system. Among all patients, 99% of those with elevated ALT levels had a score of at least F1 (positive predictive value [PPV], 99%) and 88% had a score greater than A1F1. Among patients with persistently normal ALT values, 65% had a score of at least F1 (negative predictive value [NPV], 35%) and 26% had a score greater than A1F1. The receiver operating characteristics analysis indicates that the ALT threshold for the best compromise sensitivity-specificity was about 2.25 times the upper limit of normal (ULN). In conclusion, almost all HCV RNA–positive patients with elevated ALT levels have some degree of fibrosis. However, an important proportion of patients with persistently normal ALT levels also show some histologic signs of fibrosis; the degree of fibrosis is usually mild but is sometimes more marked, and in rare cases cirrhosis may be present. In this subset of patients, the indication of liver biopsy and the potential benefit of therapy need to be further evaluated. These results suggest the need to revisit the algorithm for liver biopsy practice. (HEPATOLOGY 2002;36:973-977.)
Apoptosis and clonal growth inhibition of HBV- and SV-40 virus transfected hepatoma cells by interferon-? and tumor necrosis factor-?. Div. Gastroenterology, Dept. of Internal Medicine, Wayne State Univ. Sch. of Med., Detroit, MI 48201
Journal: Hepatology (1995)

Extensive variability in genomic sequence, especially at “hypervariable regions” within the NS1/E2 region of the long open reading frame, has been reported for RNA cloned from hepatitis C virus (HCV)-infected humans and chimpanzees. However, genetic changes of HCV occurring during the course of chronic infections in humans and animals have been evaluated only for partial sequences of the HCV genome. We compared two full-length cDNA sequences of HCV obtained from a chimpanzee that was experimentally infected with the HC-J4 strain of HCV: one during the early acute phase and another during a chronic phase 8.2 years afterward. Both isolates had 9412 nucleotides plus the 3′ poly(U) tail with varying length organized as follows: 5′UTR (1–341); C (342–914); E (915–1490); NS1/E2 (1491–2528); NS2 (2529–3359); NS3 (3360–5186); NS4 (5187–6380); NS5 (6381–9371); and 3′UTR (9372–9412). We found that 111 (1.18%) of the 9412 nucleotides differed between the two isolates and estimated the mutation rate as ≈1.44 × 10−3 base substitutions per site per year. Changes in amino acid coding were associated with 42 mutations, 8 of which were clustered at 5′ end of NS1/E2 coding region, so-called “HVR-1.” We analyzed the HVR-1 and HVR-2 sequences during the course of infection and found that homologous populations were present at the beginning of infection, and sequence heterogeneity within the region had developed 3.5 years later. Two regions of the HCV genome were characterized by a high degree of conservation of nucleotide sequence: 5′UTR and the 3′ half of the NS4 region. The possible secondary structure of the 5′UTR suggests a region for internal ribosomal entry. The 3′ half of the NS4 region may also have some specific function which depends upon a strict conservation of nucleotide sequence.
Arbeit und Gesundheit: Sozialmedizinische Schriftenreihe aus dem Gebiete des Reichsarbeitsministeriums.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pattern recognition receptors: immune targets to enhance cancer immunotherapy
Authors: T. Shekarian, S. Valsesia-Wittmann, J. Brody, M.C. Michallet, S. Depil, C. Caux, A. Marabelle
Journal: Annals of Oncology (2019)

Ann Oncol 2017; 28(8): 1756–1766 (https://doi.org/10.1093/annonc/mdx179) Correction text: In the original article, Figure 1 was incorrect. TLR5 was copied multiple times instead of TLR1,2,4,6… . This has been corrected in the online version. The Publisher apologises for the error. Pattern recognition receptors: immune targets to enhance cancer immunotherapyAnnals of OncologyVol. 28Issue 8PreviewDurable tumor responses and significant levels of disease control rates have been described in more than 20 advanced/metastatic cancer types with B7-family immune checkpoint-targeted anti-CTLA-4, anti-PD-1, and anti-PD-L1 monoclonal antibodies. These results and the recent approvals of ipilimumab, pembrolizumab, nivolumab and atezolizumab are currently revolutionizing the way we envision the future of cancer care. However these clinical benefits are not observed in all cancer types and in every patient. Full-Text PDF Open Archive
Functional disability in the hospitalized elderly
Authors: G. A. Warshaw
Journal: JAMA (1982)

Little documentation exists concerning the extent of functional disability in the hospitalized elderly and the impact of this disability on the care of these patients. A physician-led survey was conducted in a 400-bed community hospital of 279 patients aged 70 or more years. Considerable agecorrelated disability was documented. Fifty-four percent of the patients aged 85 years or older were moderately or severely disoriented. Thirty-four percent had impaired hearing, 40% had impaired vision, and 25% had speech impairments. More than half of the patients 75 years or older needed assistance with activities of daily living. Modern hospital design and services may interfere with functional recovery. Evaluation of special care units to minimize the hazards of hospitalizing the elderly is recommended. (<i>JAMA</i>1982;248:847-850)
SI Units
Authors: Patricia H. Field
Journal: JAMA (1985)

<h3>To the Editor.—</h3> You are to be commended for the Oct 12, 1984,<i>JAMA</i>theme issue on alcohol and other drugs, and for the ten recommendations in your editorial.<sup>1</sup> However, my pleasure in reading the issue was jarred by confusion about the reporting units for ethanol concentrations. Page 1886, column 1, paragraph 1, indicates that the "mean blood alcohol concentration . . . was 0.20 ± 0.08 mg/dL, or twice the level of legal intoxication (0.10 mg/dL) in Wisconsin." In fact, the ethanol level, which is illegal per se for Wisconsin drivers, is 0.10% wt, or 100 mg/dL. No doubt the mean blood alcohol concentration in the study was 0.20% wt, or 200 mg/dL. On page 1837, 0.04 mg/dL is referred to as a level that " 'has been shown to bring about measureable diminution of attention and skills,' " a statement that would be more accurate for 40 mg/dL, or 0.04% wt.
Current strategy for urban measles control. An evaluation
Authors: K. E. Nelson
Journal: JAMA (1974)

Reported measles attack rates are substantially less since licensure of vaccine. Nevertheless, measles continues to be an important cause of morbidity among inner-city populations. In an urban epidemic that occurred after vaccine licensure, the deaths, encephalitis cases, and complication rates among hospitalized patients were similar to those in a prevaccine epidemic. In the earlier and later epidemics, respectively, 23.2% and 30.1% of hospitalized patients were less than 1 year old. In the later epidemic, attack rates were much greater in lower socioeconomic areas than in higher ones. Vaccine failure did not contribute greatly to the later epidemic. Childhood measles vaccination should be given high priority. As long as measles risk remains high, vaccination appears indicated for infants 6 to 9 months old from crowded, lower-income urban areas. These infants will need booster doses later to ensure immunity.
RIO DE JANEIRO
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal