tbuckley/cabot-search huggingface dataset:
Diagnosis of Infection
Authors: D Veldhuvzen Van Zanten, R Malatjalian, D Tanton, R Leddin, W Hunt, Regimens Vakil, B Fennerty, Urease Test, R Ei-Zimaity, D Genta, S Goutier3, J -P Butzler, Burette4 H6paita, Andr6 V6saie, Deparmen Of Medficine, V Medfical
Journal: Gut (1995)

Hp may play a role in NUD but to date treatment trials have suffered from methodologic flaws.We previously validated a symptom score for use as outcome measure (J Clin Epidemiol l993;46:273) in NUD studies.In this study Hp-positive patients (N=53) suffering from NUD were randomized to triple therapy [bismuth subsalicylate (BSS) 302mg qid, amcxycillin 500mg tid, metronidazole 500mg tid] or identical looking placebo.Placebo was especially made up for BSS.Patients symptom score were taken and endoscopy performed (biopsies taken for culture and histology from antrum and body) at baseline, 6 weeks (visit 2) and 6 months (visit 3).If patients continued to be Hp-positive they were actively treated and again reviewed 6 weeks later (visit 4).Results: Four patients (two active two on placebo) dropped out of study before visit 2. Hp was eradicated in 26 of 27 :96%) patients in active group and 1 of 22 (5%) of placebo group.Although symptoms did improve throughout the study there were no significant differences at visit 2,3, or 4 in outcomes (measured on 7-point scales) : global assessment, eight upper GI- symptoms (eg epigastric pain, belching, postprandial bloating) and overall quality of life between treatment groups.It has been suggested that it may take longer for symptoms to improve following eradication, but no continuous improvement in symptom severity over time was found between visit 2 and 3 in Hp eradicated patients.The study did have 80% power to detect a two point difference on the seven point symptom score scales that were used.Conclusion: Eradication of Hp does not improve NUDsymptoms when compared to placebo.
Die Psychoanalyse und der praktische Arzt
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Author's reply: Looking for tips to find icebergs - surveillance of haemolytic uraemic syndrome to detect outbreaks of Shiga toxin-producing E. coli infection
Authors: K De Schrijver
Journal: Eurosurveillance (2008)

We agree with the authors that active surveillance of haemolytic uraemic syndrome (HUS) patients allows the detection of outbreaks of virulent STEC strains and that underascertainement of verocytotoxin-producing E. coli (VTEC) is explained by the non-routine practice of culturing stools, by the under-use of sorbitol-MacConkey (SMAC) agar, and by the fact that most clinical laboratories do not test for these micro-organisms in routine gastroenteritis samples.
Tyrosine Oxidation in Liver of Animals Poisoned with Carbon Tetrachloride: Effect of Vitamin B12 on this Process
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Book Review Diseases of the Skin . A Text-book for Practitioners and Students. By George Clinton Andrews, A.B., M.D., Associate Professor of Dermatology, College of Physicians and Surgeons, Columbia University; Consulting Dermatologist and Syphilologist to Tarrytown Hospital; to St. John's Hospital, Yonkers; to Grasslands Hospital; and to the Broad Street Hospital, New York City. 1091 pages with 988 illustrations. Philadelphia and London: W. B. Saunders Company, 1930. Cloth, $12.00 net.
Journal: New England Journal of Medicine (1930)
Successful treatment of adrenal metastases from large-cell carcinoma of the lung
Authors: P. Twomey
Journal: JAMA (1982)

Although on a weight basis the adrenal gland is the most common site of extranodal spread from lung cancer, antemortem diagnosis and successful therapy of adrenal metastasis are rare. We have treated two patients with apparently solitary metastases in the adrenal gland from large-cell carcinoma of the lung using a combination of adrenalectomy and vigorous therapy to the primary site. Both patients experienced symptomatic relief, and, in contrast to the expected short survival in lung cancer with distant metastasis, they remain well six years and 14 years after treatment. (<i>JAMA</i>1982;248:581-583)
Pituitary pigmentary hormones. Relationship of melanocyte-stimulating hormone to lipotropic hormone
Authors: J. D. Brown
Journal: JAMA (1978)

Pituitary control of pigmentation has been known for more than 60 years. Since 1969, β-melanocyte-stimulating hormone (β-MSH) has been accepted as the main pituitary pigmentary hormone in man. Its "constant companionship" with adrenocorticotrophic hormone (ACTH) has also been repeatedly demonstrated. Current investigations challenge both of these concepts. Human β-MSH immunoreactivity has been shown to be actually due to β-lipotropic hormone (β-LPH), a larger molecule that within itself contains the entire amino acid sequence of β-MSH. Human β-MSH does not exist in vivo; it is merely an extraction artifact formed by enzymatic degradation of β-LPH. It would appear likely that β-LPH, not β-MSH, is the constant companion of ACTH. (<i>JAMA</i>240:1273-1278, 1978)
Medical Students
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Institutionalization patterns among civilly committed addicts
Authors: J. C. Kramer
Journal: JAMA (1969)

An examination of institutionalization patterns of 121 civilly committed addicts over a period of 58 to 80 months (approximately 5 to 6 1/2 years) shows that while some succeed in supervised outpatient status, most do not, and those who do not will probably spend a majority of their commitment within the institution during repeated readmissions. We are left with the question whether the limited success of the program justifies such long periods of incarceration.
Nuclear beta-catenin as a marker of outcome in localized prostate cancer
Authors: L. G. Horvath, S. M. Henshall, C. S. Lee, J. G. Kench, P. D. Stricker, J. J. Grygiel, R. L. Sutherland
Journal: Journal of Clinical Oncology (2004)

9570 Background: Beta-catenin, in its role as a nuclear signaling molecule, has been implicated in prostate carcinogenesis through modulation of androgen receptor activity. Mice in whom beta-catenin is overexpressed in the nuclei of prostatic epithelium develop hyperplastic and dysplastic lesions. Hence this study focused on nuclear beta-catenin expression and aimed to define the pattern of beta-catenin protein expression in the nuclei of normal, hyperplastic and malignant human prostate tissue and to determine whether changes in expression were associated with disease progression and/or prognosis. Methods: Five normal prostates, 26 benign prostatic hypertrophy specimens, 232 radical prostatectomy specimens from patients with clinically localized prostate cancer (PC), 186 specimens of hyperplasia adjacent to PC and 20 cases of advanced PC were assessed for beta-catenin expression using immunohistochemistry. Results: There were significantly lower levels of nuclear beta-catenin expression in localized PC compared to benign prostate tissue (p<0.001). Nuclear beta-catenin expression was also lower in advanced compared to localized PC (p<0.001). In addition, lower levels of nuclear beta-catenin expression (immunoreactivity in <10% of malignant cells) predicted for a shorter biochemical relapse-free survival in patients with localized PC (HR 1.9, 95%CI 1.2–3.0; p=0.008) and were inversely correlated with pre-operative prostate-specific antigen (PSA) levels (p=0.01). Analysis of a low-risk subgroup of patients with pre-operative PSA levels <10 ng/ml (n=114), demonstrated that lower levels of nuclear beta-catenin (<10% of malignant cells) again predicted for a poorer prognosis (HR 3.2, 95%CI 1.4–7.3; p=0.006). Conclusions: Lower levels of nuclear beta-catenin expression are found in malignant compared to benign prostate tissue. Lower nuclear beta-catenin expression is also associated with a poorer prognosis in localized PC, in particular in the low-risk subgroup of patients with pre-operative PSA levels <10 ng/ml. Consequently, nuclear beta-catenin expression may be of clinical utility as a pre-operative prognostic marker in patients with low-risk PC. No significant financial relationships to disclose.
Fast-track-consultation protocol: an interdisciplinary and useful tool for treating drug user hepatitis C infection in addiction out-patient units
Authors: Silvia Acosta-López, Luz Goretti Santiago Gutiérrez, Juan Carlos Fernández Molina, Teresa De La Rosa Vilar, Magdalena Lara, Pilar Díaz Ruiz, Ana Laserna Ramos, Angelina Rodriguez Perez, Ruth Suarez Darias, Carmen Alfonso Castillón, Antonio González Rodríguez, Teresa Santana Rodríguez, Cristina Cabrera Hernández, David Rodríguez Galloway, Andrés Estévez Tejera, Julia Alcoba-Florez, Francisco Javier Merino Alonso, Francisco Andrés Pérez Hernández
Journal: Journal of Hepatology (2020)
AB0024 B-Cell Markers Expression Is Affected by TNF-Inhibitors and Tocilizumab Treatment in Rheumatoid Arthritis
Authors: R.A. Moura, C. Quaresma, A.R. Vieira, M.J. Gonçalves, J. Polido-Pereira, V. Romão, N. Martins, H. Canhão, J.E. Fonseca
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> The use of TNF-inhibitors and/or the IL-6 receptor antagonist, tocilizumab, in rheumatoid arthritis (RA) have pleiotropic effects that also involve circulating B-cells. <h3>Objectives</h3> The main goal of this study was to assess the effect of TNF-inhibitors and tocilizumab on B-cell phenotype and gene expression in RA. <h3>Methods</h3> Blood samples were collected from untreated early RA (ERA) patients, established RA patients under methotrexate (MTX) treatment, established RA patients before and after treatment with TNF-inhibitors and tocilizumab, and healthy donors. B-cell subpopulations were characterized by flow cytometry and B-cell gene expression was analyzed by real-time PCR on isolated B-cells. Serum levels of BAFF, CXCL13 and sCD23 were determined by ELISA. <h3>Results</h3> The frequency of total CD19+ B cells in circulation was similar between controls and all RA groups, irrespective of treatment. However, established RA patients under MTX treatment had significantly increased frequencies of double negative (IgD-CD27-) B cells in comparison with controls. Treatment with TNF-inhibitors and tocilizumab did not affect the circulating levels of B-cell subpopulations. CD86 and CD95 had, respectively, a significantly lower and higher expression on B-cells after anti-TNF treatment. HLA-DR MFI values were also significantly increased in RA patients after treatment with TNF antagonists and tocilizumab. BAFF-R, TACI, BCMA, CD69, CXCR5, TLR9, IgM and CD5 expression on B cells were not significantly affected by TNF-inhibitors and tocilizumab. In addition, alterations in B cell gene expression of BAFF-R, TACI, TLR9, FcγRIIB, BCL-2, BLIMP-1 and β2M were found in ERA and established RA patients under MTX treatment when compared to controls, but no significant differences were observed after anti-TNF and tocilizumab treatments when comparing baseline and follow-ups. Moreover, CXCL13 and sCD23, but not BAFF serum levels were significantly increased since early RA, but no effect of TNF-inhibitors and tocilizumab treatment was observed. <h3>Conclusions</h3> In RA patients, the use of TNF-inhibitors and/or tocilizumab treatment affects B-cell phenotype in circulation, but not B-cell frequencies or B-cell gene expression. Our results suggest that TNF-inhibitors and tocilizumab help to reduce B-cell infiltration in inflammatory sites, allowing these activated B-cells to recirculate through blood and lymphatic systems. <h3>Disclosure of Interest</h3> None declared
Author's reply
Authors: P. Smith
Journal: BMJ (1994)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following Author's reply Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Effect of lack of gravity on airborne infection during space flight
Authors: V. Knight
Journal: JAMA (1970)

In the absence of gravity during flight in space, particles with high settling velocities on earth (20μ in diameter and larger) will remain suspended in the air of a spacecraft. If such particles are contaminated with infectious agents, they will present a potentially large source of airborne infection. Particles with small settling velocities which tend to remain suspended on earth will also remain suspended in space, and thus introduce no new infectious hazard into space flight. Nasal retention under gravity of nearly all particles 20μ in diameter and larger will be similar in the absence of gravity, unless the efficiency is reduced by overloading. Pulmonary retention of small particles (6μ in diameter and smaller), which on earth penetrate to the lungs in substantial percentages, will be reduced by two thirds in the absence of gravity, thus affording some protection to the lungs of travelers in space from airborne infection.
The D allele of the angiotensin I converting enzyme is associated with diffuse in-stent restenosis
Authors: J.C. Bodart, C. Amant, C. Bauters, F. Richard, J.-M. Lablanche, N. Helbecque, E. Van Belle, E.P. Mc Fadden, M.E. Bertrand, P. Amouyel
Journal: Journal of the American College of Cardiology (1998)
L'hérédo-syphilis mentale.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
In this issue
Authors: Peter Kirkpatrick, Alexandra Flemming, Charlotte Harrison, Sarah Crunkhorn, Monica Flight, Asher Mullard, Man Tse, Mariam Faruqi, Catriona Rodwell, Matthew Smyllie, Isabel Woodman, Lucie Wootton, Lewis Packwood, Susanne Harris, Vicky Summersby, Patrick Morgan, Kirsten Managing, Judith Shadwell, Simon Fenwick, Natalie Smith, Laura Corns, Ella Lines, Dipti Shah, Marketing Managers, Tim Redding, Nazly De, La Rosa, Peter Collins, Derek Croucher, Alamy Npg
Journal: Nature Reviews Drug Discovery (2013)
Piano Man
Authors: C. Scott Williams
Journal: Annals of Internal Medicine (2012)

Ad Libitum4 December 2012Piano ManC. Scott Williams, MDC. Scott Williams, MDFrom Huntsville, AL 35801.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-157-11-201212040-00009 Audio Reading - “Piano Man” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Piano Man," by C.S. Williams, "Heart Surgeon," by B. Butka, and "Ménière's Attack," by B.E. Baldwin. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail It is not there I go to find you,Among carved stones and trees.It is here at the instrumentYour passing gifted me.Now I, like you upon a time, sit playing,Leaning carefully into the music—Touching softly the same worn ivoryYour paternal fingers once found.But I hold too long the rest,The absent beat,Hoping you will somehow reappearTo measure out, as you always did,The needed note.C. Scott Williams, MDHuntsville, AL 35801 Author, Article, and Disclosure InformationAffiliations: From Huntsville, AL 35801.Current Author Address: C. Scott Williams, MD; e-mail, [email protected]. PreviousarticleNextarticle Advertisement Audio Reading - “Piano Man” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Piano Man," by C.S. Williams, "Heart Surgeon," by B. Butka, and "Ménière's Attack," by B.E. Baldwin. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 4 December 2012Volume 157, Issue 11Page: 816 ePublished: 4 December 2012 Issue Published: 4 December 2012 Copyright & PermissionsCopyright © 2012 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Beating the Heat: Development and Evaluation of a Canadian Hot Weather Health-Response Plan
Authors: Karen E. Smoyer-Tomic, Daniel G. C. Rainham
Journal: Environmental Health Perspectives (2001)

An increasing number of cities subject to hazardous summer weather in the United States and Canada have begun to develop and implement hot weather response plans to prevent heat-related illnesses and deaths. In this study we focus on heat-mortality relationships in Toronto, Ontario, between 1980 and 1996 and evaluate the potential effectiveness of the city's interim hot weather-health response plan. Using two heat stress indexes--humidex and apparent temperature--we identified excess mortality associated with hot and humid weather and then estimated excess deaths for hot and cool summers. Mortality rates for all ages and for > 64 years age groups rose with increasing humidex and apparent temperature, with no significant increase for the population < 65 years. Excess mortality occurred as low as the 30-35 degrees C humidex range, which is below the 40 degrees C humidex used to issue a heat warning under Toronto's interim hot weather response plan. During a hot summer (such as 1988 or 1995), 32 excess deaths would be expected, whereas 34 fewer deaths than baseline levels would be expected during a cool summer like 1982 or 1992. Days with high humidex levels occur infrequently in Toronto, and thus exposure is limited under current climatic conditions. In the event of a warming climate, more days with dangerously high humidex levels are likely to occur, and summer deaths are expected to increase. Toronto's hot weather health-response plan is an important early step for adaptation to climate change.
Aberrant hepatic protein tyrosine phosphatase receptor type delta expression is a driver of metabolic liver disease
Authors: Armando Andres Roca Suarez, Atish Mukherji, Nicolas Brignon, Laurent Mailly, Frank Jühling, Marine Oudot, Sarah Durand, Patrick Pessaux, Thomas Baumert, Joachim Lupberger
Journal: Journal of Hepatology (2020)