tbuckley/cabot-search huggingface dataset:
Orthopädische Gymnastik
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prevalence [P] of molecular biomarkers [MB] expression [exp] in patients [pts] with metastatic adenocarcinoma lung [MAC]: Illinois CancerCare [ILCC] analysis.
Authors: Pankaj Kumar, Allison Frey, Jamie Harper
Journal: Journal of Clinical Oncology (2018)

e21124 Background: Treatment of MAC is guided by MB. These include Programmed Death Ligand 1 (PDL1), Epidermal Growth Factor Receptor (EGFR), Anaplastic Lymphoma Kinase (ALK) & ROS1. There is no information available on P of MB in US Midwestern population, a largely homogenous Caucasian group. We examined this question at ILCC, one of the largest practices in US midwest. Methods: We conducted a retrospective analysis of all MAC pts who presented at ILCC in 2016. We analyzed the exp of PD-L1, EGFR, ALK, and ROS1 in these pts. PDL1 status was defined as: high: if PDL1 was > 50%, low: if 5-50% and -ve: if 0-5%. High and low groups [all pts with > 5%] were designated +. Results: In 2016 there were 213 pts seen at ILCC with MAC. As of 12/2016, 121/213 [51%] pts were alive. Pts: median age 63 yrs [31-89], median PS 1 [0-3], males 50%, current/former smokers 95%, Caucasians 95%. PDL1 results were available in 79/213 pts [37%], EGFR in 182 (85%), ALK in 172 (81%), and ROS1 in 133 (62%). Previously reported papers have described PDL1+ to be as high as 58% in MAC. However, in our study only 35/79 (44%) pts were PDL1+. Though, 22/79 (28%) did have high PDL1 exp [consistent with other reports]. 13/79 (16%) had low PDL1 exp and 44/79 (56%) pts were PDL1-ve. EGFR mutation [M] was found in 36/182 (20%), ALK M was found in 3/172 (2%) pts & ROS1 M was found in 4/133 (3%), the results of these three are consistent with others. Conclusions: Our results indicate that exp of overall PDL1+ pts at ILCC is much lower than reported by others, yet the proportion of those with > 50% PDL1 in our group is similar to others. Exp of EGFR, ALK, and ROS1 in our pts is similar to other studies.
Adenocarcinoma of the duodenum and the Gardner syndrome
Authors: P. L. Schnur
Journal: JAMA (1973)

A father and his daughter, both suffering from the Gardner syndrome, came to our attention at the same time with symptoms produced by primary carcinoma of the duodenum. Duodenal polyps were also present. Studies of these and other patients with similar features strongly suggest that these lesions may be a part of this inherited condition. Roentgenographic examination of the upper portion of the gastrointestinal tract should be a routine part of the follow-up of patients with this syndrome.
Meet the First Authors
Authors: Kyeongdae Kim
Journal: Circulation Research (2018)

He is studying the role of macrophages and dendritic cells in the progression of atherosclerosis in the Laboratory of Pathophysiology, under Dr Jae-Hoon Choi's supervision.Kyeongdae became interested in innate immune cells while earning a BS in Life Sciences, and his passion for this subject has only expanded since then.He is currently participating in the Korean Mouse Phenotype Consortium team studying the effects of gene functions on foamy macrophages in atherosclerosis.After completing his military service in Korea, he intends to study treatment of various diseases, including obesity and atherosclerosis, using immune cells.In his spare time, he loves listening to music, watching movies, drawing, and playing soccer and Overwatch with friends.
The First 30 Years of Medicare and Medicaid
Authors: Nancy De Lew
Journal: JAMA (1995)

Medicare is a uniform national health insurance program for the aged and certain disabled persons. Medicaid is administered by the states within broad federal guidelines and finances health services for certain low-income groups. <h3>Trends in Enrollment, Spending, Health Status, and Managed Care</h3><h3>Enrollment.</h3> —The enactment of Medicare and Medicaid in 1965 provided health insurance coverage to millions of Americans. Medicare enrolled 19 million elderly in 1966. Medicaid was phased in by states, except Arizona, and by 1972 enrolled 18 million poor elderly, disabled, and families with dependent children. In 1972, Medicare was amended to include persons younger than 65 years with disabilities who were receiving Social Security disability benefits for 24 months or persons with end-stage renal disease (ESRD), nearly 2 million people.<sup>1</sup> Since the mid 1980s, Medicaid eligibility has been significantly expanded: enrollment increased 50% from 22 million in 1985 to 33 million in 1993. In recent years,
Effect of 5-HT<char aid="99740019" id="sub">1A</char> Receptor Gene Polymorphism on Negative and Depressive Symptom Response to Antipsychotic Treatment of Drug-Naive Psychotic Patients
Authors: Gavin Reynolds
Journal: American Journal of Psychiatry (2006)

Objective: The serotonin 5-HT 1A receptor may modulate some of the negative, cognitive, and affective symptoms of schizophrenia and is a potential target of action of some antipsychotic drugs. A functional polymorphism in the promoter region of the 5-HT 1A receptor gene is associated with depression and suicidal behavior. The authors sought to determine whether this polymorphism influences symptom response to antipsychotic drug treatment. Method: Sixty-three drug-naive patients with first-episode psychosis who were genotyped for the –1019C/G polymorphism were recruited for this study and received standard care. The Positive and Negative Syndrome Scale and the Calgary Depression Scale were used to monitor symptom changes over 3 months. Results: The polymorphism was associated with, and accounted for much of the variance in, changes in negative and depressive symptoms but not positive symptoms. Conclusions: These findings identify an important genetic factor predicting much of the response in negative and depressive symptoms to antipsychotic drug treatment.
European Perspectives
Authors: Jurriën Ten Berg, Jochem Wouter Van Werkum, Chris Hackeng
Journal: Circulation (2009)

T he primary focus for the St Antonius Centre for Platelet Function Research team is translational research related to coronary thrombosis in patients undergoing percutaneous vascular intervention.This involves research into the clinical application of platelet function tests, novel antiplatelet drugs, and all aspects of the complex role of platelets in the pathophysiology of atherothrombotic coronary disease.The team's most recent article appeared in Circulation in February 2009 and analysed the long-term clinical outcome among 431 consecutive patients with a definite stent thrombosis enrolled in a multicentre registry.It demonstrated an unfavourable outcome, with high mortality and recurrence rates.
Massive Intravascular Sickling After Replacement Transfusion with Sickle Cell Trait Blood
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Interactions of Platinum Metals and Their Complexes in Biological Systems
Authors: Andre F. LeRoy
Journal: Environmental Health Perspectives (1975)

Platinum-metal oxidation catalysts are to be introduced in exhaust systems of many 1975 model-year automobiles in the U.S. to meet Clean Air Act standards. Small quantities of finely divided catalyst have been found issuing from prototype systems; platinum and palladium compounds may be found also. Although platinum exhibits a remarkable resistance to oxidation and chemical attack, it reacts chemically under some conditions producing coordination complex compounds. Palladium reacts more readily than platinum. Some platinum-metal complexes interact with biological systems as bacteriostatic, bacteriocidal, viricidal, and immunosuppressive agents. Workers chronically exposed to platinum complexes often develop asthma-like respiratory distress and skin reactions called platinosis. Platinum complexes used alone and in combination therapy with other drugs have recently emerged as effective agents in cancer chemotherapy. Understanding toxic and favorable interactions of metal species with living organisms requires basic information on quantities and chemical characteristics of complexes at trace concentrations in biological materials. Some basic chemical kinetic and thermodynamic data are presented to characterize the chemical behavior of the complex cis-[Pt(NH3)2Cl2] used therapeutically. A brief discussion of platinum at manogram levels in biological tissue is discussed.
Tuberculin: past, present, and future
Authors: V. N. Houck
Journal: JAMA (1972)

Major discrepancies between the results obtained with the different tuberculin products labeled 5 TU have been reported<sup>1-3</sup>and are becoming increasingly familiar in recent years. Because of an instability reported in potency of reconstituted tableted purified protein derivative (PPD) tuberculins, the Division of Biologics Standards (DBS), National Institutes of Health, called together an ad hoc advisory committee on Jan 18, 1972 to make recommendations to DBS regarding tuberculin testing materials. Information relative to the problem appearing in the scientific literature, data accumulated by various groups doing comparative skin testing, and data developed by DBS, the Center for Disease Control, and the various manufacturers of tuberculin were reviewed. On the basis of the available information, the following recommendations were made: That the tableted forms of PPD tuberculin be replaced as soon as possible (but not to exceed 12 months) with liquid PPD tuberculin containing polysorbate (Tween) or a product
The relation of gastroesophageal reflux disease and its treatment to adenocarcinomas of the esophagus and gastric cardia
Authors: W. H. Chow
Journal: JAMA (1995)

<h3>Objective.</h3> —To examine the relationship of gastrointestinal disorders and their treatment to the risk of adenocarcinomas of the esophagus and gastric cardia (AEC). <h3>Design.</h3> —A medical record-based case-control study, with data collected on a standardized form by a trained abstractor, blind to the case-control status. <h3>Setting.</h3> —A large prepaid health plan. <h3>Subjects.</h3> —Case patients were plan members newly diagnosed with histologically confirmed AEC from 1986 to 1992. For each of the 196 eligible case patients, one control was selected who matched for membership at time of diagnosis, sex, year of birth, and duration of membership. <h3>Main Outcome Measures.</h3> —Association between AEC and history of gastroesophageal conditions and their treatment. Conditional logistic regression procedures were used for calculation of odds ratios (ORs) and corresponding 95% confidence intervals (CIs), with adjustment for race, smoking status, and body mass index. Medications were grouped into H<sub>2</sub>antagonists (cimetidine, ranitidine, famotidine, and nizatidine) and anticholinergics (propantheline bromide, dicyclomine hydrochloride, Donnatal [combination of atropine sulfate, hyoscyamine sulfate, phenobarbital, and scopolamine hydrobromide], and Librax [combination of chlordiazepoxide hydrochloride and clidinium bromide]). <h3>Results.</h3> —Significant twofold or greater risks of AEC were associated with a history of esophageal reflux, hiatal hernia, esophagitis/esophageal ulcer, and difficulty swallowing. The ORs increased with increasing number of these conditions. Although a fourfold risk was linked to four or more prescriptions for H<sub>2</sub>antagonists, the risk was reduced to 1.5 (95% CI, 0.4 to 5.4) after adjusting for the predisposing conditions. Further analysis revealed that the excess risk was restricted to persons with a history of gastroesophageal reflux and related conditions. No association was observed for overall use of anticholinergics. However, after adjustment for predisposing conditions, ORs decreased with increasing number of prescriptions for anticholinergics (<i>P</i>for trend=.08). <h3>Conclusions.</h3> —This study provides reassuring findings that use of H<sub>2</sub>antagonists and anticholinergics does not increase AEC risk. It also quantifies the elevated risk of AEC associated with gastroesophageal reflux disease. Further research into reflux disease and the production of premalignant epithelial changes may help elucidate carcinogenic mechanisms and measures aimed at early detection and prevention of AEC. (<i>JAMA</i>. 1995;274:474-477)
Physicians put promise of telemedicine to the test: reports from rural practitioners, anesthesiologists
Authors: D. F. Phillips
Journal: JAMA (1996)

TELEMEDICINE includes both the diagnosis and treatment of distant patients and the use of distant resources to care for patients who are close at hand. The explosive growth and development of digital technologies, high-speed communications, and imaging protocols, along with reductions in the cost of computing equipment, increased use of the Internet, and changes in the economics and organization of health care, have all spurred investments in telemedicine systems across the United States. However, efforts to evaluate their impact have been hampered by a variety of factors, including the existence of relatively few telemedicine programs, the relatively few patients seen per site, the short operating periods in demonstration projects, and the few organized attempts at collecting high-quality data. These issues were explored in several sessions at the 1996 Spring Congress of the American Medical Informatics Association, held in Kansas City, Mo. <h3>Essential to Rural Medicine?</h3> For decades, telemedicine has been
A controlled trial of teaching critical appraisal of the clinical literature to medical students
Authors: K. J. Bennett
Journal: JAMA (1987)

We carried out a controlled trial of teaching the critical appraisal of clinical literature among final-year clinical clerks. Tutors at two of four teaching hospitals were offered a short course in the critical appraisal of clinical articles that describe diagnostic tests and treatments and were assisted in identifying and appraising specialty-specific articles that described those diagnostic tests and treatments that clinical clerks were sure to encounter during their clerkship tutorials. Tutors and clerks at the other two hospitals received no special intervention and served as controls. Experimental and control clinical clerks completed pretests and posttests of their ability to take and defend a stand on whether to apply specific diagnostic tests and treatments in specific clinical situations. Experimental clerks demonstrated both statistically and "clinically" significant increases in their critical appraisal skills, improving 37% on the diagnostic test exercise and 8% on the treatment exercise; control students' scores deteriorated for both. (<i>JAMA</i>1987;257:2451-2454)
Government
Authors: Diane Rowland
Journal: JAMA (1990)

Today's health policy agenda is shaped by two often competing forces—the health care needs of the American people and the realities of budget constraints and deficit reduction. At the federal level, these forces shape spending priorities, which, in turn, tend to drive health policy and legislative priorities. Nowhere are these competing forces more obvious than in federal Medicare policy. Recent years have seen continuing increases in Medicare spending, with Medicare growing as a share of the federal budget. In 1980, Medicare expenditures of $35 billion accounted for 3% of federal outlays.<sup>1</sup>A decade later in fiscal year 1990, Medicare will spend $112 billion and consume 9% of all dollars in the federal budget. The magnitude of Medicare spending means that any curb in the rate of increase has a major impact on overall federal spending. Medicare is thus a prime target for budget reductions in the annual budget reconciliation
THE MISSION HOSPITAL AT CANTON.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Passel of "Pseudo's"
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
LECTURES ON INTRACRANIAL SURGERY.VI—BRAIN TUMOR AND ITS SURGICAL TREATMENT.
Authors: EMORY LANPHEAR
Journal: JAMA (1895)

Continuing the discussion of brain tumor and its surgical treatment, I will first speak of the <h3>Symptoms of Cerebellar Tumor.</h3> —Tumor of the cerebellum may give rise to no characteristic symptoms whatever. Loomis has reported a case in which there was simply a low grade of fever; yet the post-mortem examination revealed a cerebellar tumor as large as an orange. Commonly, however, there are marked symptoms—sometimes so pronounced as to make localization absolutely certain: vomiting with occipital headache and general failure of health, without other discoverable cause, will almost certainly call attention to the proper region; besides, as the tumor grows, pressure symptoms arise. They are thus enumerated by Wood: "Encroachment on the medulla may lead to imperfect hemiplegia or even to great motor failure; or hypoglossal, or facial, or other local paralysis may result from the pressure exerted by the enlarged cerebellar hemisphere upon nerve trunks. If the trigeminus
Heberden Society: Combined Meeting, September 1981
Authors: P Platt, S Jeffery, L Wilson, I Griffith, D Blake, A Potter, J Price, N Hall, P Bacon, J Gutteridge, B Rnhrd, M Martin, P Walker, V Wright
Journal: Annals of the Rheumatic Diseases (1981)

In recent years the crystal-induced diseases have become established as a distinct group of conditions linked by a common pathogenesis.The interactions between polymorphs and crystals is an important factor in the production of these diseases.When polymorphs phagocytose bacteria or yeasts, light is released as a chemiluminescence reaction related to the production of superoxide radicals.This reaction can be amplified chemically by the use of the chemical luminol.We have taken this tech- nique and applied it to the study of polymorpho- nuclear leucocytes and crystals.The production of chemiluminescence appears to correlate with the inflammatory potential of crystal preparations as measured by animal models.This is well illustrated by the chemiluminescence reaction produced by amorphous and microcrystalline sodium urate.Amorphous sodium urate is non- inflammatory in animal models and produces only a weak reaction, less than 10% of the response to the intensely inflammatory microcrystalline sodium urate.Crystal surfaces avidly bind protein, which has been suggested as being of importance in the modification of inflammatory potential.The chemi- luminescence reaction of uncoated microcrystalline sodium urate was 64 ± 3 5 units, the response to Cohn fraction II coated urate was significantly enhanced at 130 ± 7-1 units, whereas the response to albumin-coated urate was at background levels 5 ± 0 3 units.Luminol-dependent chemiluminescence appears to be a useful method for the study of interaction of polymorphs and crystals which has an acceptable level of reproducibility (SEM ± 5 5%) for 50 readings from 6 batches of polymorphs.