tbuckley/cabot-search huggingface dataset:
Effects of Crocidolite and Chrysotile Asbestos on Cellular Uptake and Metabolism of Benzo(a)pyrene in Hamster Tracheal Epithelial Cells
Authors: Brooke T. Mossman, Alan Eastman, Joanne M. Landesman, Edward Bresnick
Journal: Environmental Health Perspectives (1983)

The incidence of bronchogenic carcinoma is increased substantially in asbestos workers who smoke. We used several approaches to determine possible mechanisms of synergism at the cellular level between asbestos and the polycyclic aromatic hydrocarbon (PAH), benzo(a)pyrene (BaP), a chemical carcinogen in cigarette smoke. Specifically, we hypothesized that cellular uptake and metabolism of BaP might be facilitated when the hydrocarbon was coated on asbestos. In addition, we were interested in whether asbestos, alone or in combination with BaP, caused single strand breakage of DNA in epithelial cells of the airway. UICC reference samples of crocidolite and chrysotile were coated with 3H-BaP before their addition to monolayers of hamster tracheal epithelial cells. In comparative studies, 3H-BaP at identical amounts was added to cells in culture medium. At intervals thereafter, uptake of BaP by cells was documented by scintillation spectrometry and by autoradiography. In addition, cells and media were assayed by use of high pressure liquid chromatography (HPLC) to demonstrate the water-soluble metabolites of BaP. The integrity of DNA was monitored by alkaline elution at intervals after exposure of tracheal cells to various concentrations of asbestos, BaP and BaP-coated asbestos. A rapid transfer of BaP to cells occurred after addition of BaP-coated asbestos to cultures. When BaP was adsorbed to both types of fibers before their addition to cultures, 70% of the total BaP introduced entered the cell within 1 hr; 50% remained intracellular after 8 hr. In contrast, if identical amounts of BaP were added directly to medium, an initial influx of 20% was observed and cells retained only 5% of the initial amount at 8 hr.(ABSTRACT TRUNCATED AT 250 WORDS)
ON TO DETROIT
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
For deliberate election: cesarean sections in the 1890s
Authors: R. L. Martensen
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ANNUAL DUES NOW PAYABLE
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Right bundle branch block after nonpenetrating injury to the chest wall
Authors: H. F. Zinsser
Journal: JAMA (1969)

Transient right bundle branch block was observed in two patients after relatively minor trauma to the chest wall caused by a blunt object. The most consistent symptom was chest pain and the electrocardiogram was diagnostic. A routine ECG should be made in all patients with chest trauma, and serial tracings are indicated when precordial pain persists. Electrocardiograms during the acute phase are essential not only for immediate diagnosis and treatment but also to help avoid erroneous interpretations of any residual ECG changes during future examinations.
Severe Airflow Limitation After the Unifocalization Procedure
Authors: Ingram Schulze-Neick, S. Yen Ho, Andrew Bush, Mark Rosenthal, Rodney C. Franklin, Andrew N. Redington, Daniel J. Penny
Journal: Circulation (2000)

Background —While unifocalization techniques have improved the treatment options in patients with pulmonary atresia, ventricular septal defect (PA-VSD), and major aortopulmonary collaterals (MAPCAs), severe airflow limitation contributes to significant early postoperative morbidity and mortality. Although this has been attributed to bronchospasm, characteristically it is refractory to bronchodilators, suggesting that other mechanisms may play a role. Methods and Results —The clinical course and preoperative angiograms of patients who underwent unifocalization were reviewed. Patients who developed airflow limitation early after surgery underwent fiberoptic bronchoscopy. In addition, the anatomy of the MAPCAs was examined in 14 heart-lung blocks from patients with PA-VSD. Twenty-two procedures were performed in 16 children. Three developed marked airflow limitation early after surgery, necessitating prolonged high-pressure ventilation. Bronchoscopy demonstrated tracheobronchial epithelial necrosis in 2 and signs of tracheobronchial ischemia in the third. Two were successfully extubated after 15 and 16 days, but the third died after 57 days of ventilatory support. Review of the preoperative angiograms demonstrated an extensive peribronchial arterial supply arising from a MAPCA in 1 of the patients who developed severe airway necrosis after unifocalization. This was also obvious in a second patient, but the MAPCA was not included in the unifocalization. In 7 autopsy specimens, MAPCAs contributed to a peribronchial or peritracheal vascular network. Dissection of the distribution of these branches in 2 specimens revealed extensive intrapulmonary peribronchial anastomoses. Conclusions —Airflow limitation early after unifocalization is related to airway ischemia resulting from interruption of the tracheobronchial blood supply during mobilization of MAPCAs.
Handbuch der normalen und pathologischen Physiologie.
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prostaglandins
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Accurate measurement of early diastolic transmural myocardial velocity profile using tissue doppler imaging in normal subjects and patients with left ventricular hypertrophy Hirotsugu Yamada, Takashi Oki, Ryoichi Kanda, Yasuhiko Abe, Tomio Nabatame. The University of Tokushima, Tokushima, Japan, Toshiba Medical Systems Research and Development Center, Tochigi, Japan
Journal: Journal of the American College of Cardiology (2001)
Increase in AIDS-associated illnesses focuses new attention on an old nemesis
Authors: C. A. Raymond
Journal: JAMA (1986)

THIS YEAR, for the first time since such data have been collected, experts are predicting an increase in tuberculosis in the United States, attributable primarily to the disease's prevalence in patients with the acquired immunodeficiency syndrome (AIDS) (<i>MMWR</i>1986;35:74-76;<i>JAMA</i>1986;256:362-366). Recent studies have shown that tuberculosis occurs with a greater than expected frequency in patients with AIDS or those at risk of AIDS, particularly intravenous drug abusers (<i>Ann Intern Med</i>1984;101:641-645; Handwerger S, et al;<i>Chest</i>, in press). The upswing in cases in large cities, and the ripple effects of a 1985 conference on Future Research in Tuberculosis may be effecting a resurgent interest in the field that many say is long overdue. But the attention that AIDS is directing at tuberculosis is viewed as a mixed blessing. AIDS has had a "boot-leg effect" on tuberculosis research, because of the interest in understanding more about mycobacterial infections common in
Correction
Journal: Circulation Research (2015)

a correction is needed.Questions were raised about Figures 3A,3C, and 4B in the article.The antibody employed for the detection of Ki67 was a rat monoclonal while the antibodies utilized to identify Nkx2.5 and GATA4 were goat polyclonal.It was appropriate to use the same isotype control for Nkx2.5 and GATA4, but a different isotype control was introduced for the analysis of Ki67.A mistake was made in the assembly of Figures 3A, 3C, and4B.The similarity in the FACS plots resulted in an error, which has been corrected in the revised figures.For clarity, plots collected at the same time have been selected.The legends to Figures 3A,3C, and 4B remain unchanged.
Correction: Book Note
Journal: Annals of Internal Medicine (1999)

Corrections15 June 1999Correction: Book NoteFREESearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-130-12-199906150-00017 SectionsAboutVisual AbstractPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The “Related reading” section of the review of Physician's Guide to Drug Eruptions(1) incorrectly listed the authors of Cutaneous Drug Reactions: An Integral Synopsis of Today's Systemic Drugs. The authors of this book are Zürcher and Krebs.Reference1. Kurshenbaum H. Review of Physician's Guide to Drug Eruptions . Ann Intern Med. 1998;129:511. LinkGoogle Scholar Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 June 1999Volume 130, Issue 12Page: 1030KeywordsDrugs ePublished: 15 August 2000 Issue Published: 15 June 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
CHAIRMAN'S ADDRESS.
Authors: R. R. ANDREWS
Journal: JAMA (1898)

It is the usual duty of the Chairman of Sections of thisAssociationto give, in an annual address, a review of all matters new and important that have a special interest touching the scientific character of the work of the Section to which he may belong. It has been thought best to modify to some extent the nature of the subject on this, the occasion of the Golden Anniversary of theAmerican Medical Association, and to give in place a brief history of the work of the Section in the past. The history of our Section is one of which we may well be proud. Our meetings have been full to overflowing with interesting and valuable papers and discussions, and there have been many brilliant lantern exhibits. The work has been in the main along the line of higher themes in the realms of scientific research, and we may
RECENT VIEWS CONCERNING THE GENESIS OF CARCINOMA.
Journal: JAMA (1901)

Ribbert's opinions as to the early participation of the underlying connective tissue in the development of carcinoma have been the subject of a severe arraignment by Lohmer.<sup>1</sup>For a considerable period, chiefly through the work of Thiersch and Waldeyer, the origin as well as the further growth of carcinoma was held to be directly due to the proliferation of the epithelium into the deeper tissues. Ribbert and his pupils diverged from this conception in that they traced the origin of the tumor to a disconnection of the epithelial cells from their associates by processes in the subepithelial connective tissue; following such dislocations, the loosened cells proliferated to form a tumor. Such severances are, according to Ribbert, produced by the growth of the connective tissue into the epithelium, by the lengthening of the papillæ of the corium so that the interpapillary epithelial pegs become correspondingly drawn out and ultimately separated,
Intravenous Physiological Serum Perfusions in Treatment of Arthritis of Lower Extremities
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Corrigendum
Journal: BMJ (1935)

s address on circulatory diseases of the extremities is of great interest to me as I am attending a patient, aged 52, tor intermittent claudication.The x-ray report states " there is evidence of early calcification of the right popliteal and posterior tibial arteries."The pain in the leg dates from 1930.The patient 'tells me that about ten years ago his fingers used to go white, accompanied by a good deal of pain and " pins aind needles "'; this recurred during the following two years, but not since.I w,Nould like to know if other medical men have met with the two conditions-namely, intermittent claudication and IRaynaud's disease in one individual.
Picture This: Smoking Kills
Authors: M. Mitka
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Guidelines for reporting estimates of probability of paternity. Council on Scientific Affairs
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Patients with cancer prefer personalised clinical information
Journal: BMJ (1999)

Insulin four times daily is better than twice daily for diabetes in pregnancyDiabetes mellitus complicates about 5% of all pregnan› cies.Good glycaemic control reduces maternal and perinatal morbidity, but there are no data on whether intensifying insulin treatment beyond the conventional twice daily regimen is of benefit.In a randomised con› trolled open label study in nearly 400 diabetic pregnant patients Nachum et al found that a four times daily regimen improved both perinatal outcome and maternal glycaemic control compared with the conventional twice daily regimen (p 1223).The rate of severe maternal hypoglycaemia was, however, similar in both groups.
<i>History of Insanity in Great Britain.—Chapters in the History of the Insane in the British Isles</i>. By Daniel Hack Tuke, M. D., F. R. C. P., President of the Medico-Psychological Association, Joint Editor of the<i>Journal of Mental Science</i>, and formerly visiting Physician to the York Retreat, (with four illustrations). London: Kegan Paul, Trench &amp; Co., 1882; pp. 548
Journal: American Journal of Psychiatry (1882)
Subclinical Brucellosis
Authors: R. J. Henderson
Journal: BMJ (1973)

with but a single fold and this, it is sug- gested, is acceptable pending the general adoption of A5 size papers.It also in- corporates a useful gusset of about 6 mm to allow for expansion and would give a most useful increase in writing area as regards continuation cards.The large scale use by the Services would suggest possibilities of economies in its production for the N.H.S. and in filing systems.-Iam, etc.,
QRS Duration in Patients Hospitalized for Worsening Heart Failure—Reply
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal