tbuckley/cabot-search huggingface dataset:
Use of Negative Chemical Ionization Mass Spectrometry for the Trace Analysis of Metals
Authors: Terence H. Risby
Journal: Environmental Health Perspectives (1980)

The synthesis of various volatile and thermally stable derivatives of metals ions has permitted the use of conventional mass spectrometry for trace metal analysis. This paper reviews the development of the field using electron impact and chemical ionization mass spectrometry. This latter methodology produces simple mass spectra that enable complex mixtures to be analyzed. In addition the use of negative ion detection has produced selective ionization since many metal chelates contain heteroatoms which are electronegative. A discussion of the use of this general methodology for trace metal analysis is included, together with its applications to the analysis of ruthenium in automobile exhaust emissions and iron in red blood cells from laboratory rats. The future use of this methodology is expected to be for the monitoring of stable metal isotopes. This procedure could be used to follow these tracers in clinical and environmental studies and it is expected that their use will replace radioactive isotopes in most studies.
LSD: The Search
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Safety and efficacy of ketoconazole (K) in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC): Contemporary experience and prognostic indicators.
Authors: D. Keizman, P. Huang, M. A. Carducci, S. R. Denmeade, M. A. Eisenberger
Journal: Journal of Clinical Oncology (2011)

145 Background: Intracrine conversion of adrenal androgens to testosterone play an important role in CRPC progression. Treatments (tx) that block adrenal steroid synthesis have shown significant clinical benefits in mCRPC. Aims: To evaluate contemporary data on safety and efficacy associated with K in mCRPC. Methods: All/unselected mCRPC pts progressing on GnRH-a and antiandrogens (AA) treated with K were retrospectively analyzed. Pts were maintained on gonadal suppression, discontinued AA, and received and K 200-400 mg t.i.d. until disease progression or dose-limiting toxicity (DLT). Initial 600mg/d dose was escalated to 1,200mg/d if a PSA decrease was not seen at 3 months (mos) or if a response/subsequent progression to 600/mg/d was observed (optional). Follow up included hematological/chemical profile q 3 mos, scans upon clinical (physical exam/symptoms) or at biochemical progression (PSA increase ≥ 25% and ≥2ng/mL from nadir). A multivariate cox regression model was used to identify variables significantly associated with disease progression. Results: From 1999-2010 (mean follow up 40 mos, range 5-129), 114 m-CRPR pts were treated with K 200mg (n=82, 72%) or 400mg (n=32, 28%) tid. Most common grade 3/4 tox events (n=23) were fatigue, abdominal discomfort, nausea, and dizziness. 9 pts (8%) had DLT (fatigue n=7, hepatotoxicity/thrombocytopenia n=1). 55/114 (48%) had ≥ 50% PSA decline. Overall median time to progression (TTP) was 8 mos (range 1-129). 14 pts remain progression free &gt; 7 mos (range 7-129). Significant prognostic factors (table) were response to prior AA (≥6 vs &lt;6 mos), pre-tx PSADT (≥3 vs &lt;3 mos) and extent of disease (limited-axial skeleton and/or nodal vs extensive- appendicular skeleton and/or visceral). Conclusions: K is effective and safe in m-CRPC. Prior response to AA, PSADT ≥ 3mos and limited metastatic disease is associated with TTP and further supports a therapeutic role for suppressing adrenal androgens in m-CRPC. [Table: see text] No significant financial relationships to disclose.
Long Cord
Authors: P. F. R. Lankester
Journal: BMJ (1960)

attention to a valve which may be suitable ?It was originally designed to maintain a patent needle and no syringe-reflux during prolonged intravenous work.The valve is designed on the same principle as a bicycle valve and may be sterilized and re-used.It is being made by M.I.E., London, and is now in their catalogue: p. 170, Fig. 4013-Heller's Adaptor.-Iam, etc.,
Blood Pressure Studies in 14 Communities
Journal: JAMA (1977)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Middle Initial Omitted From Author’s Name
Journal: JAMA Oncology (2016)

Anusha Kalbasi, MD; Jiaqi Li, MS; Abigail T. Berman, MD; Samuel Swisher-McClure, MD; Marc Smaldone, MD; Robert G. Uzzo, MD; Dylan S. Small, PhD; Nandita Mitra, PhD; Justin E. Bekelman, MD
INTERNATIONAL CATALOGUE OF SCIENTIFIC LITERATURE.MALPIGHI, SWAMMERDAM AND LEEUWENHOEK
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Molecular epidemiology and its clinical application
Authors: J. R. Lupski
Journal: JAMA (1993)

Molecular methods have become increasingly applicable to the epidemiologic analysis of infectious disease outbreaks. Although traditional methods to characterize epidemic strains have relied on the measurement of phenotypes, such as antibiotic resistance, phage typing, or serotyping, the newer molecular methods directly examine the genotype or DNA of a specific pathogenic strain. The genotypic-based molecular methods have greater discriminatory capabilities. In this issue ofThe Journal, two elegant studies<sup>1,2</sup>apply molecular methods to examine drug-resistant<i>Staphylococcus aureus</i>outbreaks. In each case, molecular epidemiologic analysis illuminated the outbreak source, and the results had important clinical ramifications. See also pp 1323 and 1329. Back et al<sup>1</sup>examined a recurrent epidemic of erythromycin resistant<i>S aureus</i>(ERSA) infections in a well-baby nursery, using restriction endonuclease analysis of plasmid DNA (otherwise known as plasmid profiling) and genomic DNA typing by pulsed-field gel electrophoresis. The first ERSA epidemic occurred during a 7-week period in
Retinal detachment and vitreous hemorrhage due to talc emboli
Authors: L. L. Bluth
Journal: JAMA (1981)

INTRAOCULAR talc particles have been described after intravenous (IV) injection of dissolved methylphenidate hydrochloride tablets.<sup>1,2</sup>Presumably the talc, which is used as a filler in the methylphenidate tablet, is captured in the retinal capillaries, usually in the macular region. Although mild reductions in visual acuity after a talc injection have been reported,<sup>3</sup>in most cases visual acuity has been normal. We report a case of bilateral severe visual loss secondary to talc emboli. <h3>Report of a Case</h3> A 42-year-old black man was seen in December 1979 complaining of decreased vision. A "curtain" had descended into his visual field five days previously, but the patient could not tell if it was noted while using the right or left eye. The patient had been a heroin addict from 1968 to 1976. He then changed to IV injections of dissolved methylphenidate tablets, injecting from two to six tablets a day. He
KEEPING TRACK OF COMMUNICABLE DISEASES
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cardiovascular Benefits of SGLT2 Inhibitors and GLP-1 Receptor Agonists in Type 2 Diabetes
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SILENT MASTOIDITIS
Authors: GEORGE D. WOLF
Journal: JAMA (1935)

The diagnosis of silent mastoiditis is often difficult because of the very mild systemic as well as local manifestations of the disease. Silent mastoiditis may be defined as an insidious progressive destruction of the mastoid process with or without otorrhea. The disease is afebrile and painless in its course. The tympanic membrane is usually involved, the hearing may be slightly or considerably impaired, and a history of some middle ear infection is frequently obtained. Occasionally the ear condition is discovered only after the appearance of systemic or intracranial complications. In infants postauricular swelling or subperiosteal abscess may often be the first indication of mastoid involvement. The response to timely surgical intervention is usually satisfactory, but failure to recognize the condition may lead to serious consequences. Silent mastoiditis has been discussed in otologic literature under various and confusing names. Thus, Amberg<sup>1</sup>suggests dividing mastoid disease into three groups: mastoiditis acutissima,
LEGIBLE HAND WRITING.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
IMPROVED "TIME-SAVING" FORCEPS
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Whether Albumin Therapy Improves or Worsens Survival of Critically Ill Patients Is Not Known
Journal: Annals of Internal Medicine (2001)

Summaries for Patients7 August 2001Whether Albumin Therapy Improves or Worsens Survival of Critically Ill Patients Is Not KnownSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-135-3-200108070-00003 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Albumin is a protein normally found in blood. Solutions of human albumin can be given to patients through their veins (intravenously). These products are expensive and sometimes difficult to get. Albumin is usually given to people who are very ill, such as those who have severe burns, serious trauma, major surgery, shock, life-threatening infections, or liver failure. Treatment with albumin may increase blood protein levels, circulating blood volume, and blood pressure when they are abnormally low. However, whether albumin improves or worsens the chance of survival of critically ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled, “Patient Survival after Human Albumin Administration. A Meta-Analysis of Randomized, Controlled Trials.” It is in the 7 August 2001 issue of Annals of Internal Medicine (volume 135, pages 149-164). The authors are MM Wilkes and RJ Navickis.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoPatient Survival after Human Albumin Administration Mahlon M. Wilkes and Roberta J. Navickis Metrics Cited byThe SAFE Study: a landmark trial of the safety of albumin in intensive careThe SAFE study: saline vs. albumin for fluid resuscitation in the critically ill 7 August 2001Volume 135, Issue 3Page: I-25KeywordsAlbuminsBlood volumeBurnsLiverPatientsProteinsShockSurvival analysisTrauma surgeryVeins ePublished: 7 August 2001 Issue Published: 7 August 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Pulmonary edema and salicylate intoxication
Authors: G. Hrnicek
Journal: JAMA (1974)

A patient experienced pulmonary edema associated with salicylate intoxication. As proved by dynamic vascular measurements, the pulmonary edema was of noncardiac origin. Recovery followed therapy with diuretics and positive end-expiratory pressure (PEEP). The etiology of this form of pulmonary edema is unknown, but it is a potentially fatal complication of salicylate intoxication. (<i>JAMA</i>230:866-867, 1974)
John Hughes Bennett (1812-1875), clinical teacher of Edinburgh
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
British Association for the Study of the Liver
Authors: P Harrison, J Wendon, A Gimson, J O'grady, C Tan, Roger Williams, R Mathie, B Alexander, V Ralevic, G Burnstock
Journal: Gut (1991)

Patients with fulminant hepatic failure (FHF), irrespective of aetiology, have a hyperdynamic circulation.In addition, tissue oxygen con- sumption becomes dependent upon oxygen delivery as the ability to extract oxygen is reduced.In this prospective study we have investigated the changes in these circulatory abnormalities after orthotopic liver transplanta- tion in 11 patients with FHF.The systemic vascular resistance index rose from 638 (195) immediately before transplant to 1144 (292) dyn second/cm5 m2 afterwards (p<0-001), associated with an increase in mean arterial pressure from 70 (13) to 90 (12) mm Hg (p<001), despiteafallincardiacindexfrom6-8 (1-2) to 5-4 (1-7) l/minute (p<005).Although oxygen delivery remained constant at 753 ml/ minute/m2, oxygen consumption rose from 91 (25) to 136 (22) ml/minute/m5 (p<0-01) because ofan increase in the oxygen extraction ratio from 12 (1) to 19 (4)% (p<0001).Although these changes might be attributable to the rapid removal of vasoactive sub- stances by the grafted liver, the same changes were seen in two other patients studied immediately after total hepatectomy, per- formed as an emergency procedure before delayed liver grafting.On the basis ofthese findings, it is postulated that the failing liver is producing substances which lead to vasodilatation and impairment of microcirculatory blood flow.
Exposure, Metabolism, and Toxicity of Rare Earths and Related Compounds
Authors: Seishiro Hirano, Kazuo T. Suzuki
Journal: Environmental Health Perspectives (1996)

For the past three decades, most attention in heavy metal toxicology has been paid to cadmium, mercury, lead, chromium, nickel, vanadium, and tin because these metals widely polluted the environment.However, with the development of new materials in the last decade, the need for toxicological studies on those new materials has been increasing.A group of rare earths (RE) is a good example.Although some RE have been used for superconductors, plastic magnets, and ceramics, few toxicological data are available compared to other heavy metals described above.Because chemical properties of RE are very similar, it is plausible that their binding affinities to biomolecules, metabolism, and toxicity in the living system are also very similar.In this report, we present an overview of the metabolism and health hazards of RE and related compounds, including our recent studies.