tbuckley/cabot-search huggingface dataset:
Résultats de la dissection sous-muqueuse pour les carcinomes épidermoïdes de l’œsophage avec indication relative de traitement endoscopique chez les patients âgés
Journal: Endoscopy (2018)

La curabilité endoscopique pure des carcinomes épidermoïdes ne vaut qu’en cas d’absence d’invasion de la lamina-propria. En cas d’atteinte de la lamina propria ou d’une atteinte très superficielle de la sous-muqueuse (200 microns) le risque d’invasion ganglionnaire varient dans des séries chirurgicales de 0 à 25 %.
Legal abortion mortality in the United States. Epidemiologic surveillance, 1972-1974
Authors: W. Cates
Journal: JAMA (1977)

As determined by the Center for Disease Control's epidemiologic surveillance of abortion mortality, the death-to-case rate for legal abortion in the United States for the three years 1972 to 1974 was 3.9/100,000 procedures. This mortality compares favorably with that from other commonly performed surgical procedures. Women who were older, were of nonwhite races, had the procedure in their state of residence, were at later gestational age, and who underwent intrauterine instillation or major abdominal surgery had the highest mortality. Duration of pregnancy proved to be the most important determinant of risk. Compared to mortality from pregnancy and childbirth, legal abortion in the first trimester was almost nine times safer. (<i>JAMA</i>237:452-455, 1977)
PTH-166 Generation of a human oesophageal tissue culture model from forceps biopsies
Authors: LP Griffiths, JM Farrant, B Colleypriest, D Tosh
Journal: Gut (2015)

<h3>Introduction</h3> Barrett’s oesophagus is the condition whereby the normal stratified squamous epithelium at the lower oesophagus is replaced with simple columnar epithelium in the context of gastro-oesophageal reflux disease. This increases the risk of oesophageal adenocarcinoma (OA) ten-fold, and the majority of people diagnosed with OA do not survive for 12 months. Our understanding of the molecular and cellular mechanisms underlying Barrett’s oesophagus is hindered due to lack of at a suitable model. We set out to develop a model from explant tissue biopsies of adult human oesophagus, as opposed to murine models (mice have a keratinised oesophageal epithelium and do not get Barrett’s oesophagus) or the use of cell lines (which do not recapitulate the normal tissue). <h3>Method</h3> We devised a study protocol and secured ethical approval (REC reference number 13/YH/0197) to obtain forceps biopsy specimens from consenting adults attending for routine diagnostic gastroscopies at the Royal United Hospital Bath. Specimens were then transported to the University of Bath where we have tested multiple culture conditions. These include choice of culture media, substrate (eg glass, plastic – coated or uncoated, semi-permeable membrane at air/liquid interface), cell adhesion factors (eg collagen I, collagen IV, fibronectin, Matrigel®), choice of tissue preparation (enzyme treatment with dispase in the absence or presence of trypsin, dissection with scissors or minced with a blade), plating density, media volume and use of a cell feeder layer. <h3>Results</h3> We have recruited 42 participants to date and attempted tissue culture on 36 of these. (Biopsies from 6 patients have been processed for RNA analysis.) Over time we have gradually optimised culture conditions. Of the most recent 6 participants, 5 have cultured successfully with cell survival for at least 14 days. Explant colony growth had been particularly vigorous (&gt;12 mm) when plated on Matrigel® and a feeder layer cell line (mitomycin C-inactivated mouse embryonic fibroblast (iMEF) cell line 3T3-Swiss albino, ATCC® CCL-92™) on plastic coverslips. Explants have also adhered and cultured successfully on collagen IV-coated (sc-29010, Santa Cruz Biotech) plastic coverslips without a feeder layer. Explant colonies were fixed/permeabalised before immunofluorescent staining was performed for cytokeratin 14 (K14), smooth muscle actin (SMA), p63, E-cadherin and SLUG antigens. iMEFs are clearly delineated with SMA staining and the explant outgrowths are positive for K14, p63, E-cadherin and SLUG. <h3>Conclusion</h3> It is possible to culture adult human oesophageal tissue <i>in vitro</i>from standard pinch-biopsy forceps specimens at gastroscopy and we are in the final stages of optimising conditions, confirming characterisation by repeating experiments and devising a protocol. <h3>Disclosure of interest</h3> None Declared.
Council on Drugs
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Response: Magnetic Field Reports
Authors: Gary A Boorman
Journal: Environmental Health Perspectives (1998)

Results from National Toxicology Program draft reports on carcinogenesis and promo- tion of 60-Hz magnetic fields (1,2) are a mixed bag of apparent effects in some cases and no effects in other cases.The studies were carried out, apparently, with the intent to provide information that can be used in making health policy for humans.I contend that these studies cannot be used for this purpose because of two implicit assumptions that were made when the studies were being designed.First, it was assumed that the relevant magnetic field parameter for inducing biologi- cal effects is a pure 60-Hz sine-wave, and such was used.But the public is exposed to some- thing very different, as the authors admit (1):While power line magnetic field exposures are predominantly sine-wave fields, residential and occupational exposures may indude square waves, sawtooth waves, and other wave forms.Harmonics (120 Hz, 180 Hz, etc.) may also be found.Further, as appliances are switched on and off, spikes or transients in fields may occur.It is not feasible to evaluate all possible variables in large animal studies.Therefore, this study used linearly polarized, pure sine-wave exposures at 60 Hz, with the fields turned on when the sine wave was at zero amplitude and gradually increased over seven to nine cycles (between 0.11 and 0.15 seconds) to full intensity, and similarly gradually decreased to avoid transients.The NIEHS studies evaluate the predominant com- ponent (60-Hz sine-wave magnetic fields) with- out all the complexities of the exposures that occur in residential and occupational settings.
Corrigendum
Journal: Allergy (2014)

In the article by Silverberg et al. (1), a typographical error is present in the results section of the abstract.The number for severe AD/eczema is incorrectly stated as 23.89.The correct number for severe AD/eczema is 3.89.The correct sentence is reproduced below.Similar results were found for current history of epilepsy.Severe AD/eczema (3.89 [1.34-11.32])and hay fever (2.46 [1.11-5.41])were associated with even higher odds of epilepsy compared with mild/moderate disease.
Highlights
Journal: JAMA Neurology (2017)

Copy number variation (CNV) is an important cause of neuropsychiatric disorders, but little is known about its role in adults with epilepsy and intellectual disability.In a cross-sectional study of 2335 patients, including 143 adults (mean [SD] age, 24.6 [10.8] years; 69 men and 74 women) with childhood-onset epilepsy and intellectual disability, Borlot and coauthors used a genome-wide microarray for DNA screening and evaluated pathogenic CNVs.Of the 143 patients, 23 probands and 4 affected relatives presented with pathogenic or likely pathogenic CNVs, and 8 nonrecurrent rare CNVs were identified.This study suggests that a genetic approach for adult patients with epilepsy may provide insight into pathobiology.
Determination of the molecular basis of Marfan syndrome: a growth industry
Authors: Peter H. Byers
Journal: Journal of Clinical Investigation (2004)

Although it has been known for more than a decade that Marfan syndrome — a dominantly inherited connective tissue disorder characterized by tall stature, arachnodactyly, lens subluxation, and a high risk of aortic aneurysm and dissection — results from mutations in the FBN1 gene, which encodes fibrillin-1, the precise mechanism by which the pleiotropic phenotype is produced has been unclear. A report in this issue now proposes that loss of fibrillin-1 protein by any of several mechanisms and the subsequent effect on the pool of TGF-β may be more relevant in the development of Marfan syndrome than mechanisms previously proposed in a dominant-negative disease model. The model proposed in this issue demonstrates several strategies for clinical intervention.
Novel ornithine decarboxylase protein in human hepatocellular carcinoma Third Dept. of Internal Medicine, Second Dept. of Biochemistry, and Second Dept. of Surgery, Osaka City University Medical School, Osaka 545, Japan
Journal: Hepatology (1995)

Topical lidocaine has been recently marketed as a new treatment for post-herpetic neuralgia. The aim of our study was to characterize the absorption profile of and systemic exposure to lidocaine from patch and gel formulations in normal volunteers, patients with post-herpetic neuralgia, and patients with acute herpes zoster. The bioavailability of lidocaine from the patch formulation averaged 3%, and was similar after single and repeated doses. Systemic exposure to lidocaine and monoethylglycinexylidide (MEGX), the primary active metabolite of lidocaine, after application of lidocaine gel or patches was minimal in normal volunteers, patients with post-herpetic neuralgia, and patients with acute herpes zoster. Considering the benefit versus risk of topical lidocaine, systemic absorption and toxicity of lidocaine seems not to be a signi ficant risk. © 2002 Wiley-Liss, Inc. and the American Pharmaceutical Association J Pharm Sci 91:1343–1350, 2002
An Inquiry.
Authors: R. Harvey Reed
Journal: JAMA (1895)

Columbus, Ohio, Feb. 26, 1895. <h3>To the Editor:</h3> —I desire to inquire of those among your readers, who have had experience in neural infixation, to give me the following information, for which I will be pleased to give them due credit. Date and number of cases operated; cause for operation; method of operating, naming the nerve infixed as well as the nerve in which the implantation was made, also the point at which such infixation was made. My object is to gather reliable statistics in this class of surgery with a view of obtaining more light on this important subject. Very respectfully yours, 150 E. Broad Street. [Exchanges please copy.]
Leads from the MMWR. Isolation of multiple antibiotic-resistant pneumococci
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Natriuretic peptides poorly predict left ventricular function in general practice
Journal: BMJ (1998)

Routine protein energy supplementation may improve patient outcomesAlthough it is recognised that hospital patients are frequently undernourished, it is not clear if routine protein energy supplementation improves patient outcomes.On p 495 Potter et al report on a systematic review of the randomised controlled trials of routine protein energy supplementation by the oral or enteral route.Patients receiving supplements were more likely to show improvements in weight and anthropometry and were less likely to die.However, when the analysis was restricted to those trials clearly describing a good methodological design, the observed benefits were diminished.Although there may be significant and important health benefits from routine prescribing of protein energy supplementation, further large pragmatic trials are justified.
Gonorrheal Conjunctivitis
Authors: Richard W. Thatcher
Journal: JAMA (1971)

As gonorrhea increases in the United States, there is great danger that gonorrheal conjunctivitis with its serious sequelae will increase in similar proportions. Reports from several authors and personal experience indicate this may be occurring. With the increasing resistance of the gonococcus to penicillin, this drug alone may no longer be adequate therapy for gonorrheal conjunctivitis.
Biological Monitoring for Mercury within a Community with Soil and Fish Contamination
Authors: Martha Harnly, Sharon Seidel, Primitivo Rojas, Raymond Fornes, Peter Flessel, Daniel Smith, Richard Kreutzer, Lynn Goldman
Journal: Environmental Health Perspectives (1997)

To assess the impact of elevated levels of inorganic mercury in soil and dust and organic mercury in fish, biological monitoring was conducted among Native Americans living next to an inactive mercury mine in Clear Lake, California. Of resident tribal members, 46% (n = 56) participated in biomonitoring. Urine mercury levels are equivalent to background, indicating that soil and dust exposures among study participants are not substantial. The average blood organic mercury level among study participants is 15.6 +/- 8.8 micrograms/l (n = 44), which is higher than levels reported by others among those who do not consume fish (2 micrograms/l). Consistent with results from other studies, a correlation between fish consumption and blood organic mercury is observed (p = 0.03). The margin between observed and established adverse effect levels for adults is examined for blood organic mercury and found to be less than 10-fold for 20% of the study population. Protective public health efforts for the study population and other similarly exposed populations, notably those who consume commercial fish products, are considered.
Genital herpes infections in private practice in the United States, 1966 to 1981
Authors: T. M. Becker
Journal: JAMA (1985)

We analyzed data on genital herpes infections in the United States from 1966 to 1981 collected by the National Disease and Therapeutic Index survey. The number of private physician-patient consultations for genital herpes increased tenfold during this period. The number of patient visits for newly diagnosed infections increased 7.5-fold. Women aged 20 to 24 years and men aged 25 to 29 years were more likely to consult a private physician for genital herpes than were patients in other age brackets. Our analysis suggests an increasing national incidence of genital herpes infections and supports the concept that genital herpes infections are epidemic in the United States. (<i>JAMA</i>1985;253:1601-1603)
Report of the Librarian
Authors: Henry R. Viets
Journal: New England Journal of Medicine (1945)

THE Library passed through its third full year of war without damage by bombs or serious curtailment of its normal functions. It is gratifying to note that during 1944 our membership actually increased from 873 to 903, in spite of the fact that of the total membership in all classes, 177, or nearly 20 per cent, were in service with the armed forces of the United States. Also, the circulation of books and the attendance both increased over the 1943 figures, thus indicating a healthy return toward the normal of prewar usefulness. Within a year or two the Library will . . .
Reproductive toxicology. N-(hydroxymethyl)acrylamide.
Authors: Jerrold Heindel, Patricia Fail, Julia George, Thomas Grizzle
Journal: Environmental Health Perspectives (1997)

H2C=CH-C-NH-CH2-OHN-(hydroxymethyl)acrylamide (HMA) was tested for reproductive toxicity, neurotoxi- city, and dominant lethal effects in Swiss CD-1 mice, using the RACB protocol.HMA was tested as one of a series of acry- lamide congeners.HMA was chosen to rep- resent a structure for which reproductive effects were reported to be greater than the neurotoxicity.A dose-range finding study was used to help identify doses for the main study that were relatively low, to prevent debilitating neurotoxicity: Concentrations in drinking water were set at 0, 60, 180, and 360 ppm.Exposure was for up to 27 weeks.Consumption levels calculated with daily water consumption and body weights were approximately 13, 37, and 68 mg/kg for males and approximately 17, 47, and 101 mg/kg for the females.In the first generation, there was a constant trend toward reduced grip strength
The Sulfonamides
Authors: Louis Weinstein, Morton A. Madoff, Charles M. Samet
Journal: New England Journal of Medicine (1960)

IN 1942 Janeway1 summarized the developments in the field of sulfonamide therapy since its introduction in 1936. Since then, the management of a great many of the infectious diseases has been completely revolutionized by the introduction of highly active antibiotics. Experience over the past fifteen years has made it quite evident, however, that the sulfonamides continue to occupy an important, although relatively small, place in the therapeutic armamentarium of the physician and, in some cases, are more effective than other antibacterial drugs. Because of this, interest in these compounds has been maintained both in the laboratory and in the clinic; . . .
Food from the sea
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Domestic Violence Is Special Issue
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Association News.
Authors: H. L. E. Johnson
Journal: JAMA (1899)

<h3>Railroad Rates for the Columbus Meeting.</h3> —The Committee on Transportation hereby announces that the Central Passenger Association has informed the committee that a one-fare rate for the round trip has been agreed on to the Columbus meeting. Tickets to be sold on June 5 and 6 and bear return limit leaving Columbus June 10. The Central Traffic Association includes the territory east of Chicago and west of Pittsburg and Parkersburg. No trouble is anticipated by the committee in securing the above rates in the Western, Southwestern and Southeastern territories, but considerable doubt is entertained concerning the action of the Trunk Lines Association. The committee is now dealing directly with the doubtful territory and will exert every influence to secure the rate desired. A subsequent report will be made through the columns of the Journal.
CEREBROSPINAL RHINORRHEA AND OTORRHEA.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal