tbuckley/cabot-search huggingface dataset:
Update: Cholera—Western Hemisphere, and Recommendations for Treatment of Cholera
Journal: JAMA (1991)

Epidemic cholera appeared in Peru in January 1991 and subsequently spread to Ecuador, Colombia, Chile, Brazil, Mexico, and Guatemala. Cholera can be a severe, life-threatening illness but is highly preventable and easily treated; however, few health-care practitioners in the United States have experience identifying and treating cholera. This report provides an update on cholera in the Western Hemisphere and provides recommendations on the clinical diagnosis and treatment of cholera in the United States.
MGMT promoter methylation status in glioblastoma (GBM) patients: a quantitative pyrosequencing approach and its prognostic role
Authors: A. Pambuku, G. Lombardi, R. Bertorelle, L. Bellu, P. Fiduccia, M. Gardiman, Alla De Puppa, F. Berti, D. D'Avella, V. Zagonel
Journal: Annals of Oncology (2016)
Influence of concurrent medications on PSA doubling time (PSADT) in patients (pts) with nonmetastatic biochemically relapsed prostate cancer (BRPC M0) after local therapy (tx).
Authors: Daniel Keizman, Maya Ish-Shalom, Natalie Maimon, Maya Gottfried, Keren Roubinov, Roberto Pili, Victoria J. Sinibaldi, Hans J. Hammers, Michael Anthony Carducci, Mario A. Eisenberger, Wilmosh Mermershtain
Journal: Journal of Clinical Oncology (2013)

160 Background: In patients with BRPC(M0) after local tx, the most important prognostic factor is probably the PSADT (high risk &lt; 3, intermediate risk 3–8.9, low risk ≥9.0 months). Pre-clinical and clinical studies in several cancer types have shown that commonly prescribed medications may inhibit tumor growth. The effect of commonly prescribed medications on PSADT in pts with BRPC(M0) is poorly defined. We aimed to study the effect of commonly prescribed medications on PSADT in pts with BRPC (M0) after local tx. Methods: We reviewed the records of 156 BRPC(M0) pts enrolled in 1 prospective (Keizman, CCR 2010) and two retrospective (Keizman, prostate 2012; Mermershtain, EMUC 2011) studies, in 2 centers across 2 countries. The effect of clinicopathologic factors and the use of statins, aspirin, and angiotensin system inhibitors (ASIs; ACE-I and ARBs) on initial PSADT (from the time of first PSA relapse to the initiation of any systemic tx) was analyzed using the Mann-Whitney or Kruskal-Wallis tests and regression analyses. Results: In the whole patient cohort (n=156), median age was 62, prior local tx consisted of radical prostatectomy in128 pts and EBRT in 28, and median PSADT was 6.7 months (mos). Median PSADT in ASIs users (n=48) vs non users (n=108) was 7.85 vs 5.6 mos (p=0.011). In multivariate analysis, the use of ASIs and Gleason score were associated with median PSADT. The use of statins (n=58) or aspirin (n=72), primary tx modality, and time from primary tx to PSA relapse had no significant effect on median PSADT. PSADT risk grouping in ASIs users vs non users was low 48% vs 27%, intermediate 42% vs 49%, and high 10% vs 24% (p=0.02). In multivariate analysis, the use of ASIs, Gleason score, and prior ADT were associated with PSADT risk grouping. The use of statins or aspirin, primary tx modality, and time from primary tx to PSA relapse had no significant effect on PSADT risk grouping. Conclusions: The use of ASIs, Gleason score, and prior ADT may be associated with PSADT (median and risk grouping) of pts with BRPC (M0) after local tx. This should be investigated prospectively, and if validated, applied in clinical practice and clinical trials.
Response
Authors: E. WHITE
Journal: JNCI Journal of the National Cancer Institute (1988)

Journal Article Response Get access EMILY WHITE EMILY WHITE Fred Hutchinson Cancer Research Center1124 Columbia Street Seattle, WA 98104 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 80, Issue 1, 2 March 1988, Pages 2–3, https://doi.org/10.1093/jnci/80.1.2-a Published: 02 March 1988
Predicting Smoking Cessation
Authors: Susan L. Kenford
Journal: JAMA (1994)

<h3>Objective.</h3> —To identify predictors of smoking cessation success or failure with and without transdermal nicotine patch treatment. <h3>Design.</h3> —Two independent randomized, double-blind, placebo-controlled studies using the nicotine patch assessing outcome at the end of treatment and at 6-month follow-up; each study used a different mode of adjuvant counseling. <h3>Patients.</h3> —Subjects were daily smokers (≥15 cigarettes per day), aged 21 to 65 years with expired air carbon monoxide levels of at least 10 ppm, and motivated to quit. Eighty-eight subjects participated in study 1, and 112 subjects participated in study 2. <h3>Intervention.</h3> —Study 1 consisted of 8 weeks of 22-mg nicotine patch therapy with intensive group counseling. Study 2 consisted of 4 weeks of 22-mg nicotine patch therapy and 2 weeks of 11-mg nicotine patch therapy with brief individual counseling. <h3>Main Outcome Measures.</h3> —The prediction of smoking cessation (at end of treatment and after 6 months) based on pretreatment and intratreatment measures in smokers using active or placebo nicotine patches. <h3>Results.</h3> —Pretreatment markers, such as the Fagerstrom Tolerance Questionnaire score, number of cigarettes smoked per day, years smoked, expired air carbon monoxide level, or baseline blood nicotine and cotinine levels, showed no consistent relationship with successful smoking cessation across both studies. Of the intratreatment markers examined, withdrawal severity and nicotine replacement levels also were not consistently predictive of cessation success. However, any smoking during the second week of treatment was a consistent and powerful predictor of failure at the end of treatment and after 6 months. Among active nicotine patch patients who smoked at all during week 2 after quitting, 83% and 97% (studies 1 and 2, respectively) were smoking at 6-month follow-up. Conversely, abstinence during the second week of treatment predicted successful smoking cessation. Among active nicotine patch patients who were totally abstinent during week 2 after quitting, 46% and 41% (studies 1 and 2, respectively) were abstinent at 6-month follow-up. Of all nicotine patch patients in both studies who were smoking at 6-month follow-up, 74% began smoking during week 1 or 2. Among all placebo patch patients who were smoking at 6-month follow-up, 86% began smoking during week 1 or 2. <h3>Conclusions.</h3> —Smoking status (abstinent or smoking) during the first 2 weeks of nicotine patch therapy, particularly week 2, was highly correlated with clinical outcome and can serve as a powerful predictor of smoking cessation. Early smoking behavior also predicted outcome among placebo patch users. Traditional measures of dependence are not consistently predictive of cessation success. Clinicians are advised to emphasize the importance of total abstinence after a quit attempt and to follow-up with patients within the first 2 weeks of quitting; smoking during this critical time should be assessed and treatment may be altered as appropriate. (<i>JAMA</i>. 1994;271:589-594)
Silver Stools
Authors: C. P. U. Stewart
Journal: JAMA (1981)

<h3>To the Editor.—</h3> Ong and Pintauro (1979;242:2433) reviewed the literature relating to Thomas' sign (silver stool) and made the observation that the presence of the matt stainless steel stool in a patient is a "rare but specific sign of carcinoma involving the ampulla of Vater." I recently had a patient who produced a classic silver stool, and in the absence of clinical or biochemical jaundice at autopsy, showed a pathological adiposity of the pancreas despite a search for neoplasm. I would suggest that the presence of silver stools in patients, although indicating the possibility of neoplasm in the pancreas, may be associated with other pancreatic abnormalities.
&lt;TITLE&gt;Breathing Problems During Sleep&lt;/TITLE&gt;
Journal: JAMA (2001)

Many people consider snoring a minor annoyance, but it can signal a potentially serious condition called sleep apnea (temporary interruptions in breathing during sleep).An article in the June 13, 2001, issue of JAMA reports an association between sleep-disordered breathing and a genetic marker called apolipoprotein E ε4.The authors speculate that this marker may be one of many genetic factors that make someone susceptible to developing sleep-disordered breathing.
Cholestatic hepatitis caused by penicillamine
Authors: C. V. Multz
Journal: JAMA (1981)

VALUABLE as a slow-acting remission-inducing agent in the treatment of rheumatoid arthritis, penicillamine has gained progressive acceptance and increasing use throughout the world. Physicians should be alert to penicillamine as another agent capable of provoking cholestatic hepatitis, an infrequently described but important reaction. <h3>Report of a Case</h3> Therapy with penicillamine, 250 mg/ day, was started in a 53-year-old woman with rheumatoid arthritis of seven years' duration, which had been in severe exacerbation for three months. Because of the severity of her disease, the dosage was advanced rapidly to 500 mg/day after a week and 750 mg/day during the third week. Nausea, weakness, anorexia, and dark urine followed a week later. She was jaundiced and her liver edge was 3 cm below the right costal margin. She simultaneously experienced a marked amelioration of her rheumatoid disease. The penicillamine therapy was discontinued. A liver biopsy specimen and transhepatic cholangiogram demonstrated cholestatic hepatitis
Contents
Authors: C.-H Huang, Q Yuan, P.-J Chen, Y.-L Zhang, C.-R Chen, Q.-B Zheng, S.-H Yeh, H Yu, Y Xue, Y.-X Chen, P.-G Liu, S.-X Ge, J Zhang, N.-S Xia, Y.-H Ni, M.-H Chang, J.-F Wu, H.-Y Hsu, H.-L Chen, D.-S Chen, J Uhanova, R Tate, D Tataryn, G Minuk, V Hernando, S Perez-Cachafeiro, C Lewden, J Gonzalez, F Segura, J Oteo, R Rubio, D Dalmau, W Yang, B Luo, B Hu, A Maheshwari, M Fallon, M Guevara, C Terra, A Nazar, E Sola, J Ferna ´ndez, M Pavesi, V Arroyo, P Gine, L Ocuin, S Zeng, M Cavnar, E Sorenson, Z Bamboat, J Greer, T Kim, R Popow, R Dematteo
Journal: Journal of Hepatology (2012)
Hepatitis C virus chronicity is associated with a tox-1(high), Eomes(high), T-bet(dim) and PD1(high) phenotype of HCV-specific CD8+ T cells
Authors: Nils Wildner, Franziska Brauneck, Ansgar Lohse, Christin Ackermann, Julian Schulze zur Wiesch
Journal: Journal of Hepatology (2020)
Prediction of therapy‐related acute myelogenous leukemia (AML) and myelodysplastic syndrome (MDS) after autologous bone marrow transplant (ABMT) for lymphoma
Authors: Robert D. Legare, John G. Gribben, Marlon Maragh, Anne Hermanowski‐Vosatka, Sheila Roach, Ramana Tantravahi, Lee M. Nadler, D. Gary Gilliland
Journal: American Journal of Hematology (1997)

Therapy-related acute myelogenous leukemia and myelodysplastic syndrome (t-AML/MDS) are being reported with increasing frequency as a complication of ABMT for Hodgkin's disease and non-Hodgkin's lymphoma. At present there is no method available to predict who is at risk or is destined to develop this nearly universally fatal disorder. We therefore investigated whether clonal growth of cells is predictive of the development of t-AML/MDS. In a patient who developed secondary AML/MDS 18 months after ABMT, X-linked clonality analysis at the human androgen receptor locus was performed on serial banked samples, and documented transition from polyclonal to clonal hematopoiesis. Clonal cells could be identified 6 months after transplant (1 year prior to the diagnosis of t-AML/MDS), at a time when there was no morphologic or clinical evidence of disease. Clonality analysis can be predictive of the development of t-AML/MDS after ABMT and may offer important insights into associated risk factors and strategies to minimize the risk of t-AML/MDS. Am. J. Hematol. 56:45–51, 1997. © 1997 Wiley-Liss, Inc.
Environmental Science and Technology Washington, DC
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Notes on the Package Insert
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE AGING OF NATURAL MINERAL WATERS
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Eosinophilic gastroenteritis
Authors: B. Dunne, S. Brophy, J. Tsang, K. McSorley, J. Cumiskey, E. Kay, E. Mulligan
Journal: Gut (2010)

<h3>Objectives</h3> We describe the medical services provided and report the injuries and illnesses that occurred at the eighth Asian Winter Games 2017. <h3>Methods</h3> A total of 2010 athletes and team officials from 32 National Olympic Committees and 2 guest countries attended this event; medical services were provided for 16 days. Medical data (medical care and physiotherapy) were collected for the same period by the organising committee for athletes and non-athletes (team officials, workforce, media and spectators) and recorded on the electronic medical record system at the medical rooms in the venues and the team residences. <h3>Results</h3> We recorded 745 medical encounters (medical care, 443; physiotherapy, 302), of which 549 (74%) were among athletes. There were 214 injuries as well as 144 illnesses and other medical conditions. Of the 1164 athletes, 549 (47%) utilised the services. Ice hockey, snowboarding and alpine skiing had high rate of medical encounters. More than half of the delegations were not accompanied by team doctor, and rate of medical encounters was high in these teams. The vast majority of patients transferred to hospital for further care were mostly athletes (n=36 out of 41), mostly alpine skiers and ice hockey players. <h3>Conclusion</h3> Injuries and illnesses varied depending on NOC medical staffing and sport events. These data will serve organisers of medical and physiotherapy services in the Asian Winter Games and similar large events.
Medical students' attitudes toward providing care for the underserved. Are we training socially responsible physicians?
Authors: S. J. Crandall
Journal: JAMA (1993)

<h3>Objective.</h3> —To investigate the association between attitudes toward caring for the medically indigent and years of medical training. <h3>Design.</h3> —Questionnaire comparing attitudes of first-year medical students (MS-Is) and fourth-year medical students (MS-IVs). <h3>Setting.</h3> —Southwest medical school. <h3>Participants.</h3> —A total of 83 (67%) male and 41 (33%) female MS-I and 65 (73%) male and 24 (27%) female MS-IV volunteers. <h3>Main Outcome Measure.</h3> —Self-report, attitudinal scale developed for this study that provided a measure of overall attitudes, perceived societal expectations, physician/student responsibility, personal efficacy, and provision of basic services and expensive procedures. <h3>Results.</h3> —Overall attitudes were significantly less favorable for MS-IVs (95% confidence interval [CI], 99.6 to 106.2) than MS-Is (95% CI, 109.5 to 114.3,<i>P</i>&lt;.0001). Except for basic services (<i>P</i>=.46), MS-IVs had worse attitudes on all attitudes subscales. Male MS-IVs reported significantly less favorable attitudes than male MS-Is in the areas of general attitudes (<i>P</i>=.03) and physician/student responsibility (<i>P</i>=.01). Female medical students showed no significant differences across classes (<i>P</i>&gt;.05). Except for physician/student responsibility, female medical students' attitudes were more favorable than those of males, regardless of class. <h3>Conclusions.</h3> —The MS-IVs are less favorably inclined toward caring for the medically indigent than MS-Is, though these differences are apparent only for males. Further research is needed to explore why females appear to be more resistant to attitude changes, and what educational interventions are necessary to better train physicians to respond to national health care issues. (<i>JAMA</i>. 1993;269:2519-2523)
Myeloproliferative neoplasms
Authors: Jean‐Jacques Kiladjian
Journal: HemaSphere (2018)

Hôpital Saint-Louis, AP-HP, Université Paris Diderot, Inserm CIC1427, Paris France This is an open access Abstract Book distributed under the Attribution-NonCommercial-NoDerivs (CCBY-NC-ND), which allows third parties to download the abstracts and share them with others as long as they credit the author and the abstract book, but they cannot change the content in any way or use them commercially. http://creativecommons.org/licenses/by-nc-nd/4.0
Abstract 1825: Epithelial adherens junctions suppress the pro-tumorigenic MIR17HG lncRNA by recruiting RISC
Authors: Mary C. Bridges, Joyce Nair-Menon, Antonis Kourtidis
Journal: Cancer Research (2019)

Abstract The adherens junctions (AJs) are essential architectural elements of epithelial tissues. Compromised junctional integrity is a common precursor to colon cancer. Recently, we identified a novel mechanism whereby the AJs of non-transformed colon cells recruit the microprocessor and RISC, core elements of the RNAi machinery, as well as miRNAs, to suppress oncogenic mRNAs. Knockdown of the AJ component PLEKHA7, disrupts this RNAi-mediated signaling program, leading to pro-tumorigenic cell transformation. Interestingly, PLEKHA7 RNA-CLIP and subsequent RNA-Seq analysis identified association with numerous long non-coding RNAs (lncRNAs). While a number of lncRNAs have been associated with tumorigenesis, the underlying mechanisms of their regulation during tumor progression are still unclear. As lncRNAs can interact with the RNAi machinery, we hypothesize that the AJs regulate lncRNAs via this localized RNAi mechanism. Examination of PLEKHA7-depleted cells by RNA-seq revealed differential expression of 49 junction-associated lncRNAs. From this set, the top upregulated lncRNA is MIR17HG, an oncogenic polycistronic host transcript of the miR-17-92 cluster. Junctional localization of MIR17HG was confirmed by RNA-FISH. Adherens junctions destabilization by E-cadherin knockdown also led to the upregulation of MIR17HG, demonstrating the role of junctional integrity in MIR17HG suppression. Data from Ago2 knockdown, anti-miR, and miRNA mimic experiments show that PLEKHA7 suppresses the levels of the MIR17HG transcript through the junction-associated RISC and two miRNAs, miR-203a and miR-372. PLEKHA7 depletion also results in increased levels of a subset of MIR17HG hosted miRNAs, including miR-19a and miR-19b, both known cancer promoters. Ectopic expression of PLEKHA7 in the aggressive HCT116 colon cancer cells that lack endogenous PLEKHA7 expression, suppressed anchorage independent growth, as well as MIR17HG levels, which are elevated in these cells. We are currently examining the role of MIR17HG as a functional intermediate of PLEKHA7’s loss on colon cell transformation. In summary, our data point towards a novel mechanism of lncRNA regulation that tethers epithelial architecture with cell behavior. Note: This abstract was not presented at the meeting. Citation Format: Mary C. Bridges, Joyce Nair-Menon, Antonis Kourtidis. Epithelial adherens junctions suppress the pro-tumorigenic MIR17HG lncRNA by recruiting RISC [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1825.
Chloramphenicol Toxicity in Liver and Renal Disease
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal