tbuckley/cabot-search huggingface dataset:
Radiographic patterns of relapse in glioblastoma.
Authors: M. C. Chamberlain
Journal: Journal of Clinical Oncology (2010)

2021 Background: Glioblastoma pathologically is defined as an infiltrative glioma and salvage therapy with bevacizumab is believed to increase the incidence of diffuse and distant invasion as assessed radiographically. Methods: 80 adult patients with glioblastoma were treated with surgery followed by radiotherapy (RT) and concurrent and adjuvant temozolomide (TMZ). At first recurrence, all patients were treated with single agent bevacizumab. At time of progression, patients were treated with bevacizumab and a cytotoxic chemotherapy, cytotoxic chemotherapy alone or on an investigational trial. Magnetic resonance imaging (MRI) were analyzed at four time points in each patient; at presentation, at first, second and third recurrence. Four patterns of radiographic disease were assessed, local (unifocal disease), distant (second lesion noncontiguous with primary lesion), multifocal (> 2 lesions including leptomeningeal dissemination) and diffuse. Results: At presentation 87.5% of glioblastoma were local, 6.25% distant, 3.75% multifocal and 2.5% diffuse. At first recurrence following progression on RT/TMZ and before initiation of bevacizumab, 80% were local, 7.5% distant, 6.25% multifocal (including one with cerebral spinal fluid [CSF] dissemination) and 6.25% diffuse. At second recurrence following progression on bevacizumab, 71.25% were local, 8.75% distant, 8.75% multifocal (2/7 with CSF dissemination) and 11.25% were diffuse. At third recurrence (57 patients evaluable), 71.25% were local, 7.0% distant, 7.0% multifocal and 14.0% were diffuse. Survival following progression on bevacizumab did not differ by pattern of radiographic recurrence. Conclusions: A majority of adult patients with glioblastoma at diagnosis manifest MRI-defined local disease and maintain this pattern notwithstanding multiple recurrences and treatment with bevacizumab. Author Disclosure Employment or Leadership Position Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Genentech Genentech
Comparison of in-line skating injuries with rollerskating and skateboarding injuries
Authors: R. A. Schieber
Journal: JAMA (1994)

<h3>Objective.</h3> —To describe the estimated relative frequency, types of injuries, and demographic features of people injured while in-line skating, rollerskating, and skateboarding in the United States. <h3>Design.</h3> —Case series. <h3>Setting.</h3> —Emergency department visits to hospitals participating in the National Electronic Injury Surveillance System. <h3>Participants.</h3> —All persons treated for a product-related injury involving in-line skates, rollerskates, or a skateboard between July 1, 1992, and June 30, 1993. <h3>Results.</h3> —Approximately 30863 persons (95% confidence interval, 23073 to 38653) were treated for in-line skating injuries during the study period. For every in-line skating injury, approximately 3.3 rollerskating and 1.2 skateboarding injuries occurred (<i>P</i>&lt;.0001). The median age of those injured in these three sports was 15, 12, and 13 years, respectively (<i>P</i>&lt;.0001). Sixty-three percent of injured in-line skaters had a musculoskeletal injury, including 37% with a wrist injury, of which two thirds were fractures and/or dislocations. Five percent of all injured in-line skaters had head injury and 3.5% of the injured in-line skaters required hospitalization. <h3>Conclusions.</h3> —In-line skating and skateboarding injuries resulted in a similar number of emergency department visits, but fewer than that for rollerskating injuries. Because wrist fractures were the most common type of injury in all three sports, wrist protection is needed. Head protection by helmets is recommended. (<i>JAMA</i>. 1994;271:1856-1858)
Correction to: Ancient polymorphisms contribute to genome-wide variation by long-term balancing selection and divergent sorting in Boechera stricta
Authors: Baosheng Wang, Julius P. Mojica, Nadeesha Perera, Cheng-Ruei Lee, John T. Lovell, Aditi Sharma, Catherine Adam, Anna Lipzen, Kerrie Barry, Daniel S. Rokhsar, Jeremy Schmutz, Thomas Mitchell-Olds
Journal: Genome biology (2019)

Following publication of the original article [1], the authors reported that the Availability of data and materials section required updating. The updated text reads as follows:
Cytarabine, melphalan, and total body irradiation as conditioning for autologous peripheral blood stem cell transplantation for patients with acute myeloid leukemia in first remission
Authors: K. M. Kang, B. O. Choi, G. Y. Chai, Y. N. Kang, H. S. Jang, I. B. Choi, H. J. Kim, J. W. Lee, W. S. Min, C. C. Kim
Journal: Journal of Clinical Oncology (2004)

6687 Background: Current results of autologous peripheral blood stem cell transplantation (PBSCT) suggest that this procedure may prolong disease free survival in patients with acute myeloid leukemia (AML). Autologous PBSCT is increasingly used as the treatment for AML in first remission. The aim of this study was to evaluate the outcome of autologous PBSCT for the patients with AML in first remission, who were treated by autologous PBSCT using cytarabine, melphalan and total body irradiation (TBI) as the conditioning regimen. Methods: Between January 1995 and July 2000, thirty-five patients with AML in first remission underwent autologous PBSCT. The median age of patients was 33 years (range, 16 to 47). The conditioning regimen consisted of cytarabine (3.0 gm/m2 for 3 days), melphalan (100 mg/m2 for 1 day) and TBI (total 1000 cGy in five fractions over 3 days). Results: The median follow up was 43 months with a range of 3 to 72 months. The 4-year cumulative probability of disease free survival was 64.2% and median survival was 40.3 months. The 4-year relapse rate was 32.9%. The factor influencing disease free survival and relapse rate was the French-American-British classification (M3 group vs. other groups; p=0.048, p=0.043). One patient died from treatment-related toxicity. Conclusions: Although the small number of patients does not allow us to draw any firm conclusion, our results were encouraging and suggest that the association of cytarabine, melphalan and TBI as a conditioning regimen for autologous PBSCT for AML in first remission appears to be safe and effective, relatively. No significant financial relationships to disclose.
Analysis of Target Cell Susceptibility as a Basis for the Development of a Chemoprotective Strategy against Benzene-Induced Hematotoxicities
Authors: Michael A. Trush, Lorraine E. Twerdok, Stephen J. Rembish, Hong Zhu, Yunbo Li
Journal: Environmental Health Perspectives (1996)

A goal of our research is to identify biochemical factors that underlie the susceptibility of bone marrow cell populations to benzene metabolites so as to develop a mechanistically based chemoprotective strategy that may be used in susceptible humans exposed to benzene.By doing biochemical risk analysis of bone marrow stromal cells from mice and rats and the human myeloid cell lines, HL-60 and ML-1; and by using buthionine sulfoximine and dicumarol we have observed that the susceptibility of these cell populations to hydroquinone (HQ) correlates with their concentration of glutathione (GSH) and activity of quinone reductase (QR).Accordingly, the induction of QR and GSH by 1,2-dithiole-3-thione (D3T) in these cell populations has resulted in a significant protection against the following hydroquinone-mediated toxicities: inhibition of cell proliferation and viability; reduced ability of stromal cells to support myelopoiesis; and altered differentiation of ML-1 cells to monocytes/macrophages.Preliminary in vivo experiments indicate that feeding mice D3T results in an induction of QR in the bone marrow compartment such that stromal cells are more resistant to hydroquinone-induced cytotoxicity in vitro.Overall, these studies suggest that in addition to hepatic cytochrome P4502E1, bone marrow OR and GSH are factors that could determine an individual's relative susceptibility to the toxic effects of benzene.
MEDICAL NEWS
Journal: JAMA (1967)

<h3>The Early Diagnosis Of Aldosteronism</h3> Sufficient clinical experience has been accumulated to confirm that primary aldosteronism is the cause of elevated blood pressure in a significant number of patients previously regarded as essential hypertensives. In the two years since Jerome W. Conn, MD, and his co-workers at the University of Michigan School of Medicine first reported a case of<i>normokalemic</i>primary aldosteronism (<i>JAMA</i><b>193</b>:200-206 [July 19] 1965) the Michigan group has screened 184 patients with essential hypertension and found aldosteroneproducing tumors in 14 (7.6%). <h3>Significant Number</h3> "No one anywhere in the world has done enough work yet to know precisely how many people thought to have essential hypertension actually have primary aldosteronism, but it will be a significant number," Dr. Conn told the annual meeting of the Canadian Medical Association. Since hypertension in most patients with primary aldosteronism is cured or substantially alleviated by surgical removal of the
Der Tonus der Skelettmuskulatur.
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A note from the editors: 2011 in numbers and developments foreseen for 2012
Authors: None Eurosurveillance editorial team
Journal: Eurosurveillance (2012)

Preview this article: A note from the editors: 2011 in numbers and developments foreseen for 2012, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/17/1/art20051-en-1.gif
BLU-667 Controls <i>RET</i>-Altered Thyroid Cancers
Journal: Cancer Discovery (2019)

The experimental RET inhibitor BLU-667 appears safe and effective in patients with RET-altered thyroid cancers, according to findings presented at the 2019 American Society of Clinical Oncology Annual Meeting. In the phase II ARROW trial, the drug elicited responses in 56% of patients with advanced RET-mutated medullary thyroid cancer and five out of six patients with papillary thyroid cancer and was associated with mild side effects.
Disease Clusters
Authors: Mike Mitka
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Two Lines Omitted
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Vulnerability of Children and the Developing Brain to Neurotoxic Hazards
Authors: Bernard Weiss
Journal: Environmental Health Perspectives (2000)

For much of the history of toxicology, the sensitivity of the developing organism to chemical perturbation attracted limited attention.Several tragic episodes and new insights finally taught us that the course of early brain development incurs unique risks.Although the process is exquisitely controlled, its lability renders it highly susceptible to damage from environmental chemicals.Such disturbances, as recognized by current testing protocols and legislation such as the Food Quality Protection Act, can result in outcomes ranging from death to malformations to functional impairment.The latter are the most difficult to determine.First, they require a variety of measures to assay their extent.Second, adult responses may prove an inadequate guide to the response of the developing brain, which is part of the reason for proposing additional safety factors for children.Third, neuropsychological tests are deployed in complex circumstances in which many factors, including economic status, combine to produce a particular effect such as lowered intelligence quotient score.Fourth, the magnitude of the effect, for most environmental exposure levels, may be relatively small but extremely significant for public health.Fifth, changes in brain function occur throughout life, and some consequences of early damage may not even emerge until advanced age.Such factors need to be addressed in estimating the influence of a particular agent or group of agents on brain development and its functional expression.It is especially important to consider ways of dealing with multiple risks and their combinations in addition to the prevailing practice of estimating risks in isolation.
Critical Care
Authors: Lindell K. Weaver
Journal: JAMA (1997)

Overall, the third edition of<i>Critical Care</i>, edited by Civetta, is a helpful text for the critical care practitioner. Section 1 is particularly refreshing because it covers issues in medical decision making. The first chapter discusses briefly how to read and understand medical articles and statistics. This is fundamental for practitioners in pulmonary and critical care medicine. The first section continues by reviewing a collaborative practice approach, clinical decision making, and ethics, including informed consent and refusal. These chapters are especially pertinent to the practice of critical care. Chapter 8 on iatrogenesis is important for all physicians, including those who practice critical care. The treatment of physiologic mechanisms in section 2 is similar to other critical care texts (eg,<i>Intensive Care</i>, edited by Rippe et al, and<i>Principles and Practice of Medical Intensive Care</i>, edited by Carlson and Geheb). Some of the material is more up-to-date in this newer text.
Teaching Methods in Medicine: The Application of the Philosophy of Contemporary Education to Medical Schools.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Books Received
Journal: JNCI Journal of the National Cancer Institute (1965)

Journal Article Books Received Get access Entstehung und Wachstum des zervixkarzinoms. By Hillemanns Von Hans-Günter. 224 p. $14.35. Albert J. Phiebig, Post Office Box 352, White Plains, New York, 1964. Berufskrebs (Beiträge zur Krebsforschung, Band 9). By Hueper W. C.. 122 p. 18.60 DM. Theodor Steinkopff, Dresden, Loschwitzer Strasse 32, Germany, 1964. Selected papers on virology. Edited by Hahon Nicholas. 363 p., $10.00. Prentice-Hall, Englewoods Cliffs, New Jersey 07632, 1964. Geriatric institutional management. Edited by Leeds Morton & Shore Herbert. 445 p. $8.50. G. P. Putnam's Sons, 200 Madison Avenue, New York, N.Y.Injuries. By Curry George J.. 256 p. $6.50. G. P. Putnam's Sons, 200 Madison Avenue, New York, N.Y.Style manual for biological journals. By Committee on Form and Style of the Conference of Biological Editors. 117 p., $3.00. The American Institute of Biological Sciences, 2000 P Street, N.W., Washington 6, D.C., 1964. A study on proteinbound sulfhydryl groups in pulmonary cytodiagnosis. By Wiman Lars-Gösta. 124 p. Price: Sw.Kr.40. Almquist & Wiksell, Stockholm, Sweden, 1964. Învătămîntul medical și farmaceutic din Bucuresti. Edited by Institutul de Medicina si Farmacie Bucuresti. 604 p. Price: Lei 25. Biblioteca Facultatii de Medicina din Bucuresti, Institutul Medico Farmaceutic, 1963. JNCI: Journal of the National Cancer Institute, Volume 34, Issue 1, January 1965, Page 153, https://doi.org/10.1093/jnci/34.1.153 Published: 01 January 1965
Home-Based Cardiac Rehabilitation: A Scientific Statement From the American Association of Cardiovascular and Pulmonary Rehabilitation, the American Heart Association, and the American College of Cardiology
Authors: Randal J. Thomas, Alexis L. Beatty, Theresa M. Beckie, LaPrincess C. Brewer, Todd M. Brown, Daniel E. Forman, Barry A. Franklin, Steven J. Keteyian, Dalane W. Kitzman, Judith G. Regensteiner, Bonnie K. Sanderson, Mary A. Whooley
Journal: Circulation (2019)

Cardiac rehabilitation (CR) is an evidence-based intervention that uses patient education, health behavior modification, and exercise training to improve secondary prevention outcomes in patients with cardiovascular disease. CR programs reduce morbidity and mortality rates in adults with ischemic heart disease, heart failure, or cardiac surgery but are significantly underused, with only a minority of eligible patients participating in CR in the United States. New delivery strategies are urgently needed to improve participation. One potential strategy is home-based CR (HBCR). In contrast to center-based CR services, which are provided in a medically supervised facility, HBCR relies on remote coaching with indirect exercise supervision and is provided mostly or entirely outside of the traditional center-based setting. Although HBCR has been successfully deployed in the United Kingdom, Canada, and other countries, most US healthcare organizations have little to no experience with such programs. The purpose of this scientific statement is to identify the core components, efficacy, strengths, limitations, evidence gaps, and research necessary to guide the future delivery of HBCR in the United States. Previous randomized trials have generated low- to moderate-strength evidence that HBCR and center-based CR can achieve similar improvements in 3- to 12-month clinical outcomes. Although HBCR appears to hold promise in expanding the use of CR to eligible patients, additional research and demonstration projects are needed to clarify, strengthen, and extend the HBCR evidence base for key subgroups, including older adults, women, underrepresented minority groups, and other higher-risk and understudied groups. In the interim, we conclude that HBCR may be a reasonable option for selected clinically stable low- to moderate-risk patients who are eligible for CR but cannot attend a traditional center-based CR program.
Severe Plasmodium Falciparum Malaria Is Associated with Circulating Ultra-Large Von Willebrand Multimers and ADAMTS13 Inhibition
Authors: Deirdre Larkin, Vince P Jenkins, James Bunn, Alister G Craig, Roger JS Preston, Cynthia Donkor, George E Grau, Jan A van Mourik, James S O’Donnell
Journal: Blood (2008)
Response
Authors: J. L. REPACE, A. H. LOWREY
Journal: JNCI Journal of the National Cancer Institute (1989)

Journal Article Response Get access JAMES L. REPACE, JAMES L. REPACE U.S. Environmental Protection AgencyWashington, DC 20460 Search for other works by this author on: Oxford Academic PubMed Google Scholar ALFRED H. LOWREY ALFRED H. LOWREY Naval Research Laboratory WashingtonDC 20375 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 81, Issue 18, 20 September 1989, Pages 1425–1426, https://doi.org/10.1093/jnci/81.18.1425-a Published: 20 September 1989
Caveolin-1–dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo
Authors: Amanda M. Marchiando, Le Shen, W. Vallen Graham, Christopher R. Weber, Brad T. Schwarz, Jotham R. Austin, David R. Raleigh, Yanfang Guan, Alastair J.M. Watson, Marshall H. Montrose, Jerrold R. Turner
Journal: The Journal of Experimental Medicine (2010)