tbuckley/cabot-search huggingface dataset:
Correction
Authors: Jonas S€ Oderholm, Charlotta Millbourn, Katharina Usch, Jan Ovamees, Robert Schvarcz, Karin Lindahl, Annette Bruchfeld
Journal: Hepatology (2016)

Background Studies have shown chronic hepatitis C (CHC) negatively impact kidney function, as well as survival for patients with chronic kidney disease (CKD) or on hemodialysis (HD).The aim of this registry study was to describe renal disease for Swedish CHC patients.Methods The patients were identified for CHC (B18.2) and CKD (N18) according to ICD-10 in the inpatient care day surgery and non-primary outpatient care in the nationwide Swedish Patient Register (2001-2013).HD was defined using the procedure code in the non-primary outpatient care.Treatment (IFN/RBV) was identified using ATC codes in the Prescribed Drug Registry.For each patient up to 5 non-CHC diagnosed age/sex/place of residency-matched comparators were drawn from the general population at time of diagnosis.Follow-up started at date of CHC diagnosis and patients accrued person-years (PY) in until death, emigration or 31st Dec 2013, whichever came first.Results During 2001 and 2013, 42,522 visited a physician with a CHC diagnosis.Of these were 2.5% (n51,077) diagnosed with CKD during 280,123 PY, compared with 0.7% (n51,454) in the matched comparators (1,504,765 PY) resulting in a standardized incidence ratio (SIR) of 4.0.The frequency of CHC patients on HD was 0.63% compared with 0.10% in the matched comparators.Overall, 17% (45/ 268) of the CHC patients on HD had been treated for CHC, and 24% (11/45) in the treated cohort died compared with 56% (127/223) in the untreated cohort (P<0.0001; Figure ).A multivariate regression analysis showed CHC treatment, kidney transplantation, and younger age at first HD to independently be associated with better prognosis for CHC patients on HD.The hazard ratio for not receiving CHC treatment adjusted for age at HD and kidney transplantation was 2.84 (1.52-5.39).Discussion The result from this nationwide registry study showed CHC patients to be at higher risk of developing CKD.Also treatment for CHC improved survival for CHC patients on HD.
Postlabeling Methods for Carcinogen-DNA Adduct Analysis
Authors: Kurt Randerath, Erika Randerath, Hari P. Agrawal, Ramesh C. Gupta, Mark E. Schurdak, M. Vijayaraj Reddy
Journal: Environmental Health Perspectives (1985)

Radioactive carcinogens have provided most of our present knowledge about the chemistry of interactions between carcinogens and biological systems. The requirement of radioactive carcinogens has restricted carcinogen-DNA binding studies to chemicals that are readily available in isotopically labeled form, i.e., a minute fraction of all potentially mutagenic or carcinogenic chemicals. To extend the scope of carcinogen-DNA binding studies, an alternative method, which does not require radioactive test chemicals, has been developed. In this approach, radioactivity (32P) is being incorporated into DNA constituents by polynucleotide kinase-catalyzed [32P]phosphate transfer from [gamma-32P]ATP after exposure of the DNA in vitro or in vivo to a nonradioactive, covalently binding chemical, and evidence for the alteration of DNA nucleotides is provided by the appearance of extra spots on autoradiograms of thin-layer chromatograms of digests of the chemically modified DNA. Quantitation of adduct levels is accomplished by scintillation counting. The sensitivity of the technique depends on the experimental conditions for 32P-labeling and on the chemical structure of the adducts. Greater sensitivity may be achieved if adducts can be separated as a class from the normal nucleotides. This is the case for an estimated 80% of all carcinogens, giving rise to bulky and/or aromatic substituents in DNA. Under the present conditions, one such adduct in 10(9) to 10(10) normal nucleotides can be detected. A total of approximately 80 compounds has been studied thus far Binding to DNA of rodent tissues was readily detected by the 32P-postlabeling assay for all known carcinogens among these compounds, and adducts were detected in DNA from human placenta of smokers.
Cutaneous complications in immunosuppressed renal homograft recipients
Authors: F. C. Koranda
Journal: JAMA (1974)

Skin complications were studied in a consecutive series of 200 renal transplant patients treated with immunosuppressive agents. Cushing syndrome changes were the most common reaction, more than half of the patients having altered fat distribution, steroid-induced acne, atrophic and friable skin, striae, dry skin, and keratosis pilaris. Cytotoxic alopecia was encountered in 54%, but hair regrew in all cases. Skin infections were common, especially verrucae (43%), herpes simplex (35%), herpes zoster (13%), and tinea versicolor (18%). De novo skin cancers occurred in 3.5%. Other disorders included acanthosis nigricans, cold intolerance of the front teeth, metastatic calcification, red lunulae of the nails, and hyperpigmentation of exposed skin. Skin complications in transplant patients ranged from minor annoyances to life-threatening conditions. The frequency of dermatologic problems and the possible sequelae stress the need for periodic examinations by a dermatologist and for education of the patients in the care of their skin. (<i>JAMA</i>229:419-424, 1974)
A MEDICO-LITERARY CURIOSITY FROM CHINA.
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Jaundice following the administration of niacin
Authors: A. A. Sugerman
Journal: JAMA (1974)

CHOLESTATIC jaundice is a recognized complication of massive doses of niacin.<sup>1</sup>Recovery usually occurs after the therapy is discontinued. The present case is of interest in that the dosage was moderate (750 mg daily) and the duration relatively short (less than three months). Nevertheless, a reaction to niacin appears to be a reasonable explanation of the patient's jaundice. <h3>Report of a Case</h3> A 69-year-old white man became bored with his inactive retirement and attempted suicide by car exhaust fumes. Five months earlier he had had an apparent stroke and developed a parkinsonian tremor, difficulty in walking, episodic memory difficulties, and increasing depression. He was lethargic but not comatose when admitted to a general hospital for emergency treatment after his suicide attempt, and three days later he was transferred to a psychiatric hospital. Findings were consistent with organic brain syndrome, with psychological tests indicating intellectual deterioration and right-hemisphere damage. The
Inactivated hepatitis A vaccines
Authors: S. M. Lemon
Journal: JAMA (1994)

In this issue of<i>JAMA</i>, Innis and colleagues<sup>1</sup>describe a remarkable clinical trial of a new, formalin-inactivated hepatitis A vaccine performed among 40 119 children in Thailand. An impressive effort, this study compared the frequency of hepatitis A in children aged 1 to 16 years after two or three doses of either the hepatitis A vaccine developed by SmithKline Beecham Biologicals, Rixensart, Belgium, or a recombinant hepatitis B vaccine. The hepatitis A vaccine was found to be highly effective in preventing symptomatic illness associated with elevated serum alanine aminotransferase and positive IgM antibodies to hepatitis A virus (HAV). No serious adverse reactions were noted after administration of more than 109 000 doses. This is the second clinical trial to document efficacy of an investigational, formalin-inactivated hepatitis A vaccine; it follows the 1992 report of a similar vaccine developed by Merck Research Laboratories, West Point, Pa, See also p 1328.
RECENT DEVELOPMENTS IN THE STUDY OF CANCER ETIOLOGY.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Highlights
Authors: Howard Bauchner
Journal: JAMA (2015)

Dextromethorphan-Quinidine for Agitation in Alzheimer Disease 1242Safe and eff ective treatments for agitation among patients with Alzheimer disease are lacking.In a 10-week, randomized, placebo-controlled study that enrolled 220 patients with probable Alzheimer disease and clinically signifi cant agitation, Cummings and colleagues found that the combination of dextromethorphan and quinidine demonstrated clinically relevant effi cacy for agitation and was generally well-tolerated.In an Editorial, Ballard and colleagues discuss pharmacologic management of agitation among patients with dementia.
Epidemiologic Approaches for Assessing Health Risks from Complex Mixtures in Indoor Air
Authors: Jonathan M. Samet, William E. Lambert
Journal: Environmental Health Perspectives (1991)

Indoor air may be contaminated by diverse gaseous and particulate pollutants that may adversely affect health. As a basis for controlling adverse health effects of indoor air pollution, the presence of a hazard needs to be confirmed, and the quantitative relationship between exposure and response needs to be described. Toxicological, clinical, and epidemiological studies represent complementary approaches for obtaining the requisite evidence. The assessment of the effects of complex mixtures poses a difficult challenge for epidemiologists. Understanding the effects of exposure may require accurate assessment of concentrations and personal exposures to multiple agents and analytical approaches that can identify independent effects of single agents and the synergistic or antagonistic effects that may occur in mixtures. The array of epidemiological study designs for this task includes descriptive studies, cohort studies, and case-control studies, each having potential advantages and disadvantages for studying complex mixtures. This presentation considers issues related to exposure assessment and study design for addressing the effects of complex mixtures in indoor air.
Constructing contempt
Authors: Victoria L. Spring, C. Daryl Cameron, Kurt Gray, Kristen A. Lindquist
Journal: Behavioral and Brain Sciences (2017)

Abstract Gervais &amp; Fessler argue that contempt is a natural kind and that its experience cannot be explained by a constructionist account of emotion. We dispute these claims and offer a positive constructionist model of contempt that accounts for the existing evidence and unifies conflicting findings in the literature on contempt.
A CASE OF SPOROTRICHOSIS IN CONNECTICUT
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cardioversion During Pregnancy
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE POSTULATES OF ROBERT KOCH
Journal: JAMA (1961)

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Medical ethics' assault on medical values
Journal: JAMA (1984)

<h3>To the —</h3> The notion that "autonomy ethics" has emerged as a result of the "dominant school in medical ethics... subvert[ing] values intrinsic to medicine" is naive. Emphasis on individual rights and avoidance of paternalism over the weak and stress on the freedom of individuals to choose for themselves are themes that have dominated all aspects of American society for the last two decades. The expression of these themes within medicine in the form of "autonomy ethics" is but one example of the way medicine reflects the values of the larger society. After criticizing moral philosophers for seeking universal and absolute status for their principles and rejecting the alternatives to autonomy ethics as "subjective," Clements and Sider<sup>1</sup>offer up their own moral absolutes in the form of "biological norms." Yet Clements and Sider's naturalistic, biological norms are just as assuredly "social constructs" as is the concept of autonomy. There are
Erratum
Journal: JNCI Journal of the National Cancer Institute (1992)

Response by S. Piantadosi to correspondence by V. Torri et al. entitled “Relationship Between Response and Survival in Patients With Advanced Ovarian Cancer“ [J Natl Cancer Inst 84:899–900, 1992 (issue II)]. Piantadosi writes: “I wish to correct an error surrounding my correspondence concerning ‘Statistical Model to Determine the Relationship of Response and Survival in Patients With Advanced Ovarian Cancer Treated With Chemotherapy,’ article by V. Torri et al. [J Natl Cancer Inst 84:407–414, 1992 (issue 6)]. In my original editorial, ‘Assessing the Effect of Response on Survival in Ovarian Cancer’ [J Natl Cancer Inst 84:376–378, 1992 (issue 6)], the vertical axes of Figs. 2 and 3 actually show log{p1(1−p1)/p2(1−p2)} rather than log odds ratios as labeled. The figures for log odds are similar but not identical to the ones published.”
Vascular Surgery
Journal: JAMA (1972)

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Current Comment
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Annual and Analytical Encyclopedia of Practical Medicine.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Liver stiffness by transient elastography to detect porto-sinusoidal vascular liver disease in patients with portal hypertension
Authors: Laure Elkrief, Lazareth Marie, Sylvie Chevret, Valérie Paradis, Laura Rubbia-Brandt, Francois Durand, Castera Laurent, Payance Audrey, Malphettes Marion, Aurélie Plessier, Cendrine Chaffaut, Etienne Audureau, Dominique Valla, Pierre Nahon, Nathalie Ganne-Carrié, Pierre-Emmanuel Rautou
Journal: Journal of Hepatology (2020)
Idiopathic hypertrophic subaortic stenosis and bacterial endocarditis
Authors: J. P. Nagle
Journal: JAMA (1967)

BROCK demonstrated in 1957 that muscular hypertrophy can obstruct the outflow tract of the left ventricle during systole.<sup>1</sup>During the past decade, numerous reports have helped to clarify the symptoms, signs, and hemodynamic phenomena that characterize the idiopathic form of hypertrophic subaortic stenosis. Bacterial endocarditis has so rarely occurred in association with this entity that the following case is reported. Acute endocarditis developed in an otherwise normal aortic valve in a patient with idiopathic hypertrophic subaortic stenosis. <h3>Report of a Case</h3> A 34-year-old man was well until 1957 when he began experiencing exertional dyspnea and angina pectoris. In early 1958, a cardiac murmur was detected and an electrocardiogram showed QS deformity in V<sub>1-3</sub>and left ventricular hypertrophy. Catheterization of the right side of the heart demonstrated normal findings, and the initial impression was arteriosclerotic heart disease and mitral insufficiency. In 1961, digitalis administration was begun because of increasing