tbuckley/cabot-search huggingface dataset:
Environmental Health Sciences Center Task Force Review on Halogenated Organics in Drinking Water
Authors: M. Deinzer, F. Schaumburg, E. Klein
Journal: Environmental Health Perspectives (1978)

The disinfection of drinking water by chlorination has in recent years come under closer scrutiny because of the potential hazards associated with the production of stable chlorinated organic chemicals. Organic chemical contaminants are common to all water supplies and it is now well-established that chlorinated by-products are obtained under conditions of disinfection, or during tertiary treatment of sewage whose products can ultimately find their way into drinking water supplies. Naturally occurring humic substances which are invariably present in drinking waters are probably the source of chloroform and other halogenated methanes, and chloroform has shown up in every water supply investigated thus far. The Environmental Protection Agency is charged with the responsibility of assessing the public health effects resulting from the consumption of contaminated drinking water. It has specifically undertaken the task of determining whether organic contaminants or their chlorinated derivatives have a special impact, and if so, what alternatives there are to protect the consumer against bacterial and viral diseases that are transmitted through infected drinking waters. The impetus to look at these chemicals is not entirely without some prima facie evidence of potential trouble. Epidemiological studies suggested a higher incidence of cancer along the lower Mississippi River where the contamination from organic chemicals is particularly high. The conclusions from these studies have, to be sure, not gone unchallenged. The task of assessing the effects of chemicals in the drinking water is a difficult one. It includes many variables, including differences in water supplies and the temporal relationship between contamination and consumption of the finished product. It must also take into account the relative importance of the effects from these chemicals in comparison to those from occupational exposure, ingestion of contaminated foods, inhalation of polluted air, and many others. The susceptibility of different age, genetic, and ethnic groups within the population must also be carefully considered. The present review discusses: the reasons for disinfection; the general occurrence of chlorinated organics in drinking water; the chemistry in the synthesis of chlorinated organics under aqueous conditions; and alternatives to chlorine for disinfection.
Correction: Endoscopic subtypes of colorectal laterally spreading tumors (LSTs) and the risk of submucosal invasion: a meta-analysis
Authors: Roel Bogie, Manon Veldman, Luc Snijders, Bjorn Winkens, Tonya Kaltenbach, Ad Masclee, Takahisa Matsuda, Eveline Rondagh, Roy Soetikno, Shinji Tanaka, Han-Mo Chiu, Silvia Sanduleanu-Dascalescu
Journal: Endoscopy (2017)

Correction to: Endoscopic subtypes of colorectal laterally spreading tumors (LSTs) and the risk of submucosal invasion: a meta-analysisEndoscopy 2018; 50(03): 263-282DOI: 10.1055/s-0043-121144
Abstract 4410: Predictive model of palbociclib response reveals indications in which CDK4/6 inhibitor can be a potential combination partner
Authors: Marc Hafner, Nicholas Dompe, Wei Zhou, Eva Lin, Milena Durrbaum, Anneleen Daemen, Melissa R. Junttila, Ciara Metcalfe, Karl Merrick
Journal: Cancer Research (2019)

Abstract CDK4/6 inhibitors are a promising class of targeted therapies, with three molecules (palbociclib, ribociclib, and abemaciclib) approved for advanced hormone-receptor positive (HR+) breast cancers. With hope of building on this success, clinical trials across multiple oncology indications have been initiated. The determinants of response to CDK4/6 inhibitors, beyond pRb-deficiency and Cyclin-E amplification, remain unclear as limited clinical data have been published in indications other than HR+ breast cancers. Here, we measured the response to palbociclib across a panel of tumor cell lines from multiple indications and were able to build a computational model predictive of drug response using the expression of a handful of transcripts. This model revealed cellular states that are related to palbociclib resistance, such as G1-S entry deregulation, or sensitivity, such as competent p53 pathway and high KRAS signaling. As validation of our model, we compared its predictions with dependency scores from Project Achilles and found good correlations between predicted sensitivity and dependence on CDK4 and CCND1. By applying the predictive model on TCGA data, our analysis uncovered indications, disease subtypes, and genomic alterations that are related to the predicted response to palbociclib in addition to Rb-deficiency and Cyclin-E amplification. As expected, HR+ breast cancer was predicted to be among the most sensitive diseases, along with prostate, thyroid, and some renal cancers. Among non-small cell lung cancers, squamous-cell tumors are predicted to be more resistant than adenocarcinomas. In adenocarcinomas, BRAF and KRAS mutations are predicted to be associated with increased responsiveness. Combining these results with published biomarkers of resistance to standard of care therapies reveals indications in which CDK4/6 inhibitors can be potential combination partners. These results may guide the design of new trials for CDK4/6 therapies and the evaluation of better stratification biomarkers. Citation Format: Marc Hafner, Nicholas Dompe, Wei Zhou, Eva Lin, Milena Durrbaum, Anneleen Daemen, Melissa R. Junttila, Ciara Metcalfe, Karl Merrick. Predictive model of palbociclib response reveals indications in which CDK4/6 inhibitor can be a potential combination partner [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4410.
Diet and Exercise for Obese Patients With Heart Failure—Reply
Authors: Dalane W. Kitzman, Mark J. Haykowsky, William Kraus
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Influence of left bundle branch block on the prognostic value of QT dynamicity for major arrhythmic events in idiopathic dilated cardiomyopathy Laurent Fauchier, Dominique Babuty, David Tena-Carbi, Olivier Marie, Philippe Poret, Marie Laurence Autret, Pierre Cosnay, Jean Paul Fauchier. Cardiologie B, Centre Hospitalier Universitaire Trousseau, Tours, France
Journal: Journal of the American College of Cardiology (2001)
"PRURIGO ANNULARIS."
Authors: J. H. TWISTON DAVIES
Journal: British Journal of Dermatology (1941)

Journal Article “PRURIGO ANNULARIS.” Get access J. H. TWISTON DAVIES J. H. TWISTON DAVIES Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 53, Issue 5, 1 May 1941, Pages 143–145, https://doi.org/10.1111/j.1365-2133.1941.tb10540.x Published: 01 May 1941
Unilateral leg edema, migraine, and methysergide. A clinical presentation of retroperitoneal fibrosis
Authors: W. J. Farrell
Journal: JAMA (1969)

A patient who was taking methysergide maleate for migraine headaches had painless unilateral leg edema as the only symptom of retroperitoneal fibrosis. Unilateral obstruction was present but asymptomatic in the upper urinary tract. Extrinsic pelvic venous obstruction without intravascular thrombosis was the cause of the edema. Treatment, consisting of surgical release of the vein and discontinuance of the drug therapy, resulted in a prompt and satisfactory response. Marked arterial narrowing was also present but was not apparent on an aortogram.
Angina May Require Drastic Change in Habits
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Familial aggregation of lipids and lipoproteins and early identification of dyslipoproteinemia. The Collaborative Lipid Research Clinics Family Study
Authors: J. A. Morrison
Journal: JAMA (1983)

We examined the hypothesis that familial aggregation of lipids and lipoproteins facilitates within-family identification and hyperlipoproteinemia. We studied 841 offspring and 1,236 siblings of normocholesterolemic probands, 833 offspring and 1,194 siblings of hypercholesterolemic probands, 806 offspring and 1,099 siblings of normotriglyceridemic probands, and 877 offspring and 1,108 siblings of hypertriglyceridemic probands in the Lipid Research Clinics Collaborative Family Study Program. As the categorization of probands' hypercholesterolemia or hypertriglyceridemia increased from sporadic, to persistent, to severe, the percentage of hypercholesterolemic or hypertriglyceridemic offspring and siblings increased. Close sibling and parent-offspring lipid and lipoprotein risk factor associations in hypercholesterolemic and hypertriglyceridemic family units during and after the period of shared common-household environment facilitate within-family identification of dyslipoproteinemia and suggest potential sharing of coronary heart disease risk. (<i>JAMA</i>1983;250:1860-1868)
Immunization
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Acute Oliguria
Authors: John T. Harrington, Jordan J. Cohen
Journal: New England Journal of Medicine (1975)

THE conventional approach to the differential diagnosis of oliguria (50 to 400 ml of urine per day) focuses first on establishing the anatomic location of the initiating disturbance. Within this framework, the causes of acute oliguria can be grouped into one of three classes: inadequate renal perfusion (pre-renal or functional azotemia); obstruction (post-renal azotemia); and intrinsic renal diseases. The logic of this classification centers about the paramount importance of excluding rigorously both pre-renal and post-renal disorders, for which specific therapy is often curative, before one assumes the presence of intrinsic renal disease, for which immediate, specific treatment is only rarely . . .
Chlorine under seige.
Authors: Joe Hollingsworth
Journal: Environmental Health Perspectives (1994)

9-m = I-gal DoublespeakIn a seeming reversal of the Dabert v. Merrell Dow Pharmacec case in which the Supreme Court held that judges could no longer require that scientific evidence be based on "generally accepted, (i.e., peer-reviewed) research techniques, a federal appeals court has ruled that a judge may refuse to allow juries tO hear scientific evi- dence the court determines is unreliable.Although many attorneys had predicted that the Daubert ruin would pave the way for juries to hear novel scientific evidence, the Sixth U.S. Circuit Court of Appeals in Cincinnati interpreted the requirement of Daubert that trial judges scruti- nize scientific testimony to mean that judges may review scientific evidence and decide that it is not reliable enough to sustain a jury verdict. in Conk v. Vehsico a family sued the Velsicol Chemical Corporation for health problems resulting from the use ofthe company's pesticide, chlordane, in their home.Although the attorneys for the plaintiffs argued that Daubert and the rules of evi- dence permit the jury to hear all scientific evidence and weigh its credibility, the trial judge found that the testimony of the expert witnesses for the fmily had not estab- lished that long-term exposure to small amounts ofchlordane had caused the family health problems.
The Pulmonary Extracellular Lining
Authors: Gerwyn George, Gary E. R. Hook
Journal: Environmental Health Perspectives (1984)

The extracellular lining of the lungs is reviewed. The pulmonary extracellular lining is a complex mixture of phospholipids, proteins and carbohydrates which is absolutely essential for the maintenance of normal pulmonary functions such as gas exchange. Without the lining the lungs would collapse. Alterations in the pulmonary extracellular lining may underlie some disease conditions induced by toxic agents, especially those which interfere with the formation of pulmonary surfactant. The extracellular lining could be used to detect and monitor damage and disease caused by agents toxic to the lungs. The lining contains many hydrolytic enzymes which may act to detoxify certain toxic agents such as those which contain ester groups. The pulmonary extracellular lining could play a significant role mediating the toxic action of inhaled agents as well as the removal of those agents from the lungs.
Analysis of the prognostic significance of circulating tumor DNA (ctDNA) in metastatic castrate-resistant prostate cancer (mCRPC).
Authors: Justin Shaya, James Michael Randall, Frederick E. Millard, Razelle Kurzrock, J Kellogg Parsons, Pablo Tamayo, Rana R. McKay
Journal: Journal of Clinical Oncology (2020)

110 Background: Given the technical limitations of obtaining tissue next-generation sequencing, there has been interest in blood ctDNA to assess genomic alterations in mCRPC. We examined the genomic landscape and prognostic significance of ctDNA in mCRPC. Methods: Single center retrospective analysis of mCRPC patients who underwent ctDNA genomic profiling using Guardant360. Overall survival (OS) and time to progression (TTP) were examined and stratified by the presence of tumor suppressor mutations (p53, PTEN, Rb), androgen receptor (AR) amplification or mutation, number of genomic alterations, and highest allelic fraction of detected mutations. Results: At the time of ctDNA collection, all patients (n=46) had mCRPC with bone metastases present in 100% of patients and visceral metastases present in 17.3%. Median age at ctDNA collection was 71 years, median time from CRPC diagnosis to ctDNA was 13 months (range 0-45), and median follow-up time from CRPC diagnosis was 17.5 months (4-40). The most common alterations present were TP53 mutation (41.3%), AR amplification (30.4%), and CDK6 amplification (21.7%). Actionable mutations were detected in BRCA1 (4.3%), BRCA2 (4.3%), ATM (2.2%), and PMS2 (2.2%). The median number of genomic alterations was 2 (0-8) and the median ctDNA allelic fraction was 4.6% (0-86.9%). Median OS of the cohort was 36 months. The presence of a tumor suppressor mutation, &gt; 2 genomic alterations, and &gt;5% mutation allelic fraction was associated with inferior OS (Table). In terms of time to progression on 1st line abiraterone or enzalutamide, the presence of an AR amplification or mutation was associated with significantly worse median TTP of 6.9 vs 13.5 months ( p- 0.015). Conclusions: ctDNA is frequently detected in mCRPC; and the type, number and frequency of alterations are potentially prognostic of OS in mCRPC. Ongoing studies are needed to assess concordance of ctDNA with tissue NGS and the predictability of ctDNA.[Table: see text]
Effects of Arsenic Cell Metabolism and Cell Proliferation: Cytogenetic and Biochemical Studies
Authors: Johannes Petres, Diethart Baron, Manfred Hagedorn
Journal: Environmental Health Perspectives (1977)

Chromosome analysis of lymphocytes from patients who had been exposed to arsenic showed frequent structural and numerical aberrations, even with an interval of decades since the last exposure. The in vitro addition of sodium arsenate induced the same chromosome changes--even to extreme of chromosome pulverizations--upon lymphocyte cultures from healthy subjects. Radioactive incorporation studies showed that arsenate was able to inhibit dose-dependently the incorporation of radioactively labeled nucleotide in RNA and DNA. Beyond that, arsenic blocked the cells in the S- and G2-phase. A general explanation for the inhibitory effect of inorganic arsenic on cell metabolism is the known strong affinity of arsenic to enzymes, especially to those containing sulfhydryl groups.
Discussion: session 1. Detection of health effects of exposure to low doses of agents—scientific constraints*
Authors: Edward Radford, Nurtan Esmen, Yves Alarie
Journal: Environmental Health Perspectives (1981)

The discussion opened with consideration of the suitability of animal models for extrapolation to human disease.Dr. Alarie pointed out that for some carcinogens, such as vinyl chloride, animal data had proved to be quite predictive of human effects.He commented that methods developed by Dow Chemical Company in studying uptake and excretion of several chemicals had taken account of metabolic differences between animals and man, when the human data were available.He also believes that by means of kinetic models, for at least some inhaled chemicals, it will be possible in the next few years to estimate human effects from animal data in reasonably quantitative terms.Dr. Land mentioned that for a physical agent such as ionizing radiation, animal data were useful for studying mechanisms of action.There followed discussion of the comparability of routes of exposure.Dr. Julian Andelman (Univer- sity of Pittsburgh) asked if inhalation exposure limits could give guidance to exposure limits for chemicals in water or food.There was general agreement by Drs.Esmen and Alarie that for some materials which are absorbed and metabolized in the same way, regardless of route of entry, this approach was reasonable, but in general such
Atypical monocytes in a patient with Hodgkin's disease
Authors: W. M. Butler
Journal: JAMA (1982)

ATYPICAL monocytes and Sternberg-Reed cells have been described in leukocyte concentrations of peripheral blood in patients with Hodgkin's disease.<sup>1</sup>The atypical monocytes were either large with irregular nuclei or large with numerous vacuoles. Using similar leukocyte concentration techniques, Hoerni and co-workers<sup>2</sup>demonstrated Sternberg-Reed cells or atypical monocytes during nine of 19 pyrexic episodes in 24 patients with Hodgkin's disease. However, only one of 27 samples collected during periods without pyrexia contained abnormal cells.<sup>2</sup> We have recently seen a patient with periodic fevers of nearly 12 months' duration. Large vacuolated monocytic cells were seen in routine peripheral blood films during episodes of pyrexia. These monocytes closely resembled the atypical monocytes that have been described in leukocyte concentrations of patients with Hodgkin's disease. Our patient was found to have Hodgkin's disease after a lengthy evaluation. <h3>Report of a Case</h3> A 41-year-old man had a 12-month history of recurrent fevers,
Twelve Million Children Immunized Against Measles; Cases Drop Sharply
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Preparation, Premedication, and Surveillance
Authors: G. D. Bell, A. Quine
Journal: Endoscopy (2006)

The "State of the Art" section in Endoscopy has now been replaced by "Endoscopy Essentials". For the last 8 years, either our Italian colleagues Dr. Lazzaroni and Professor Biancho Porro [1] or the present first author [2] have tried each year to give an overview of all relevant publications during the preceding 12 months. The editors of Endoscopy made an effort to restrict us to no more than 50 references per article, although last year we note that it crept up to 74 [1]! This year, the editors have been much more radical - our instructions were: "A maximum of five papers published in the last year are to be selected and for each paper selected, cite no more than four additional references."