tbuckley/cabot-search huggingface dataset:
PURULENT BRAIN DEPOSITS, AND PHLEBITIS AND THROMBOSIS OF THE CEREBRAL VEINS AND SINUSES FOLLOWING EAR DISEASE.
Authors: FRANK ALLPORT
Journal: JAMA (1892)

(<i>Continued from page 580</i>.) <i>Case 111</i>.—Treated by Moss of Heidelberg. Right. ear. Acute otitis; pain in right forehead and temple, chills; constipation; somnolence; impaired vision; delirium; sudden rise and fall of temperature. Death. <i>Autopsy</i>.—Thrombosis right lateral sinus, and internal jugular vein. Phlebitis of emissary mastoid vein. <i>Case 112</i>.—Treated by Moss of Heidelberg. Right ear. Chronic otorrhœa; intense pain in right side of head. Death. <i>Autopsy</i>.—Thrombosis of sigmoid flexure. Thrombosis of right lateral sinus. Lepto-meningitis. <i>Case 113.</i>—Treated by Moss of Heidelberg. Right ear. Chronic otorrhœa; chills; pain in occiput; vomiting. Death. <i>Autopsy</i>.—Phlebitis and thrombosis of lateral sinus. Meningitis. Cholesteatoma in mastoid cells. <i>Case 114</i>.—Treated by Moss of Heidelberg. Chronic otorrhœa; pain in ear, forehead and occiput; fever; œdema of temple; headache; stupor; spasms of upper extremities. Death. <i>Autopsy</i>.—Phlebitis and thrombosis of lateral and superior petrosal sinuses. Circumscribed basilar meningitis. <i>Case 115</i>.—Treated by Burckhardt-Merian. Age, one. Left ear. Chronic otorrhæa; external opening
Risk of hepatitis C virus infections through household contact with chronic carriers: Analysis of nucleotide sequences
Authors: M Honda
Journal: Hepatology (1993)

We evaluated the risk of hepatitis C virus transmission through household contact with chronic carriers using nucleotide sequence analysis. Chronic hepatitis C patients (76 patients) were divided into two groups: familial transmission of hepatitis C virus was studied in group A (53 patients); group B (23 patients) served as nonfamilial controls for group A. Of 88 family members of group A patients, 18 (20%) had elevated serum ALT levels, 20 (23%) had antibodies against hepatitis C virus and 16 (18%) had hepatitis C virus RNA in serum. Nucleotide sequences of the region of the hepatitis C virus genome spanning the core and envelope genes were compared among the three groups. In group B, the average nucleotide sequence homology was 91.0% ± 2.29% (a pairwise comparison was made for each of the patients; n = 253). Isolates from two family members were significantly more homologous to isolates from corresponding patients in group A than to isolates from group B patients. Of the two isolates from family members, one was from a child whose mother was a patient (97.7% homology) and one was from a spouse (98.1% homology). These results strongly suggest familial transmission of the same hepatitis C virus strain. Further studies are necessary to elucidate the route of intrafamilial transmission. (HEPATOLOGY 1993;17:971–976.)
Reply
Authors: F Hadziselimovic
Journal: Gut (1996)

Colonic epithelial cells express HLA-DR in inflammatory bowel disease. The effect of drugs used in the treatment of inflammatory bowel disease and colchicine on interferon-gamma (IFN-gamma) induced DR expression has been investigated. HT-29 cells were cultured in 25 cm2 flasks. At 48 hours interferon-gamma (0, 50, or 100 U/ml) +/- drug were added. At 120 hours the cells were stained for HLA-DR and analysed by flow cytometry. 10(-2) M 5ASA reduced DR expression induced by 50 U/ml interferon-gamma from 62 (12)% of cells (mean SD) to 29 (20)% (p less than 0.005). Corresponding figures for 10(-2) M N-acetyl 5ASA were 68 (16)% to 39 (17)% (p less than 0.05); for 10(-2) M 4ASA, 61 (4)% to 57 (4)% (p = 0.6); for 10(-2) M N-acetyl 4ASA, 60 (12)% to 35 (13)% (p less than 0.05); for 10(-2) M olsalazine, 72 (9)% to 3 (1)% (p less than 0.001); for 10(-3) M olsalazine, 72 (9)% to 16 (10)% (p less than 0.001); for 10(-6) M colchicine, 62 (13)% to 5 (3)% (p less than 0.001); and for 10(-7) M colchicine, 62 (13)% to 10 (3)%. Similar results were obtained when DR was induced by 100 U/ml of interferon-gamma except with 10(-2) M 4ASA which reduced expression from 77 (4)% to 68 (3)% (p less than 0.05). Sulphapyridine, prednisolone, indomethacin and cyclosporin A had no effect. Concurrent staining with propidium iodide showed that these results were unchanged when viable cells alone were analysed. Prior incubation of cells with drug, followed by washing, had no effect on interferon-gamma induced DR expression. 5ASA, N-acetyl 5ASA, 4ASA, N-acetyl 4ASA, olsalazine and colchicine reduce interferon-gamma induced HLA-DR expression. In inflammatory bowel disease these compounds may impair antigen presentation by the colonic epithelium.
Cadmium and Zinc Relationships
Authors: Carl-Gustaf Elinder, Magnus Piscator
Journal: Environmental Health Perspectives (1978)

Cadmium and zinc concentrations in kidney and liver have been measured under different exposure situations in different species including man. The results show that zinc increases almost equimolarly with cadmium in kidney after long-term low-level exposure to cadmium, e.g., in man, horse, pig, and lamb. In contrast, the increase of zinc follows that of cadmium to only a limited extent, e.g., in guinea pig, rabbit, rat, mouse, and chicks. In liver, the cadmium--zinc relationship seems to be reversed in such a way that zinc increases with cadmium more markedly in laboratory animals than in higher mammals. These differences between cadmium and zinc relationships in humans and large farm animals and those in commonly used laboratory animals must be considered carefully before experimental data on cadmium and zinc relationships in laboratory animals can be extrapolated to humans.
THE EXPLOSION OF CURRENT BELIEFS.
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Notes from overground. Fourth year at Harvard Medical School
Authors: D. J. Bressler
Journal: JAMA (1981)

IT IS too late for first impressions and too early for memoirs, yet I want to try to leave some record of what I have learned in medical school. This is not an essay on electrolyte changes in chronic renal failure or the differential diagnosis of hemoptysis. Rather, it tells what one medical student gleaned incidentally, between the lines of the formal medical school instruction. The last 3 1/2 years have changed the way I think of myself. I have gone from considering myself a "layperson" to thinking of myself as a physician. Much of this transformation is related to the body of information I have been so busy accumulating—information that has allowed me to participate in decisions concerning the welfare and fate of my patients. But a large part of the change is due to my exposure to "medical" experiences rather than to the accumulation of bits of information.
Donut Falls, Wasatch National Forest, Utah
Journal: JAMA Internal Medicine (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Current smoking trends in the United States. The 1981-1983 behavioral risk factor surveys
Authors: P. L. Remington
Journal: JAMA (1985)

Based on the aggregate of behavioral risk factor surveys, almost one third of adults were smokers in 1982. Overall, significantly fewer Hispanics smoked compared with whites or blacks. Among young adults, however, the rate of smoking was highest among whites compared with blacks and Hispanics. Compared with nonsmokers, smokers—especially young women—had higher rates of other risk behaviors, including alcohol misuse and lack of seat-belt use. Since 1965, the rate of decline of smoking among women has not been as great as that among men, due in part to the high rate—more than 40%—of smoking among young white women. Despite continued decrease in the overall proportion of smokers, the high rate among young women emphasizes the need for continued efforts toward prevention and cessation, before the well-documented health consequences develop. (<i>JAMA</i>1985;253:2975-2978)
Abstract 3306: Prognostic value of clinical signs at admission in patients with primitive liver cancer at university hospital of Yopougon: Retrospective cohort study
Authors: Djivede Renaud Jutor Tchibozo
Journal: Cancer Research (2019)

Abstract Introduction: The primitive liver cancer (PLC) is common in Ivory Coast and has a late diagnosis. The PLC has a bad prognosis and few studies have assessed the predictive role of the clinical signs at admission, namely abdominal pain (AD), edematous-ascitic syndrome (OSA), febrile ascites (AF), and Digestive hemorrhage (HD) on the prognosis of patients with PLC . Objective: To determine the prognostic role of clinical signs in the admission of hospitalized patients for PLC at University Hospital of Yopougon. Patients And Methods: A retrospective cohort study of 126 patients (average age : 48.2 years, men = 71.4%) hospitalized for PLC at University Hospital of Yopougon from 2012 to 2016 was conducted in the Medicine and Hepato-Gastroenterology Department. For each patient the socio-demographics, clinicals, biologicals and endoscopics data and survival time were collected. These parameters were analyzed by Kaplan Meier methods and Cox proportional hazards with a significance set at 5%. The risk is expressed in terms of chance ratio (HR) with the confidence interval. Results: The patients were admitted for DA (32.5%), SOA (50%), AF (7.1%) and HD (10.3). The median duration of follow-up was 0.28 months. The mortality rate was 38.9% (49 of 126 patients) during follow-up. It was 12.7% for AD, 16.7% for SOA, 4.8% for AF and 4.8% for HD. The median overall survival was 0.8 (95% CI: 0.5-1.4) months. It was 0.7 (95% CI: 0.5-2) months for AD, 1.1 (95% CI: 0.4-1.1) months for OSA, 0.3 (95% CI: 0.21-3.6) months for AF and 1.1 (95% CI: 0.6-16.2) months for HD. In multivariate analysis, the predictive factors for mortality were: male sex (HR = 2.12, 95% CI: 1.08-4.17, p = 0.03), AF (HR = 4.51; 95% CI: 1.30 - 15.70, p = 0.02) and the presence of esophageal varicose (HR = 3.43, 95% CI 1.78-6.62, p &amp;lt;0.0001). Conclusion: Patients suffering from PLC have a higher risk of death due to the presence of febrile ascites or esophageal varicose on admission. Note: This abstract was not presented at the meeting. Citation Format: Djivede Renaud Jutor Tchibozo. Prognostic value of clinical signs at admission in patients with primitive liver cancer at university hospital of Yopougon: Retrospective cohort study [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3306.
Abstract 5100: C-Reactive Protein and Parental History Improve Global Cardiovascular Risk Prediction: The Reynolds Risk Score for Men
Authors: Paul M Ridker, Nina P Paynter, Nader Rifai, Michael Gaziano, Nancy R Cook
Journal: Circulation (2008)

Background. CRP and family history independently associate with future cardiovascular events and have been incorporated into risk prediction models for women (the Reynolds Risk Score for women). However, no cardiovascular risk prediction algorithm incorporating these variables currently exists for men. Methods. Among 10,724 initially healthy American non-diabetic men who were followed prospectively for incident cardiovascular events over a median period of 10.8 years, we developed a cardiovascular risk prediction model that included hsCRP and parental history of myocardial infarction before age 60 years, and compared model fit, discrimination, and reclassification to prediction models limited to age, blood pressure, smoking, total cholesterol, and high-density lipoprotein cholesterol. Results. 1,294 cardiovascular events accrued during study follow-up. Predictive models incorporating hsCRP and parental history (the Reynolds Risk Score for men) had better global fit (P&lt;0.001), a superior (lower) Bayes Information Criterion (BIC)(23008 vs 23048), and larger C-indexes (0.708 vs 0.699, P &lt; 0.001) than did predictive models without these variables. For the endpoint of all cardiovascular events, the Reynolds Risk Score for men reclassified 17.8 percent of the study population into higher- or lower-risk categories with markedly improved accuracy among those reclassified. In models based on the ATP-III preferred endpoint of coronary heart disease and limited to men not taking lipid-lowering therapy, 16.7 percent of the study population were reclassified to higher- or lower-risk groups, again with significantly improved global fit (P&lt;0.001), smaller BIC (13870 vs 13891), larger C-index (0.714 vs 0.704, P &lt; 0.001), and almost perfect accuracy among those reclassified (99.9 percent). For this model, NRI was 8.4 percent and CNRI 15.8 percent (both P-values &lt; 0.001). Conclusion. We developed an improved global risk prediction algorithm for men incorporating hsCRP and parental history that should allow better targeting of preventive therapies to maximize benefit while minimizing toxicity and cost.
Contents
Authors: Lawrence Brierley, Rupal Trivedi, M Wilson, Mohammad Pakravan, Shahin Yazdani, Mohammad-Ali Javadi, Heidar Amini, Zohreh Behroozi, Hossein Ziaei, Marzieh Katibeh, Reza Solaimanizad, Elham Ghahari, Mehdi Yaseri, Scott Smith, Kuldev Singh, Shan Lin, Philip Chen, Teresa Chen, Brian Francis, Henry Jampel, Gabriele Lang, András Berta, Bora Eldem, Christian Simader, Dianne Sharp, Frank Holz, Florian Sutter, Ortrud Gerstner, Paul Mitchell, David Brown, Dong Nguyen, Dennis Marcus, David Boyer, Sunil Patel, Leonard Feiner, Patricio Schlottmann, Amy Rundle, Jiameng Zhang, Roman Rubio, Anthony Adamis, Jason Ehrlich, J Hopkins, Jie Xu, Liang Xu, Kui Fang Du, Lei Shao, Chang Chen, Jin Zhou, Ya Wang, Sheng You, Jost Jonas, Wen Bin, Kevin Tozer, A Roller, Lawrence Chong, Srinivas Sadda, James Folk, Vinit Mahajan, Stephen Russell, H Culver Boldt, Elliott Sohn
Journal: Ophthalmology (2013)
Use of Cancer Incidence Data in Identification of Cancer Causation
Authors: Elsebeth Lynge
Journal: Environmental Health Perspectives (1996)

This paper discusses the use of cancer incidence data in identification of cancer causation.Selective descriptive and analytical epidemiological studies were reviewed.These examples were taken primarily from Denmark, where the possibilities for epidemiological research are good due to the existence of many exposure and disease registers.Descriptive studies are still needed for a better understanding of cancer.Analytical studies of individual risk factors today often show relative risks of only 1.5 to 2, and these are difficult to translate into preventive recommendations.Epidemiology still remains the best available tool for identification of risk factors.
MEDICAL PROGRESS
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE MECHANISM OF THE GALLBLADDER
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Film: Flawless
Authors: S. Carr
Journal: BMJ (2000)

Written and directed by Joel Schumacher MGM & Optimum Releasing, on worldwide general release, in British cinemas 24 November Rating: ![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img> After Flatliners (1990) and Dying Young (1991), Joel Schumacher continues his fascination with illness and medicine in his latest picture. Unlike the previous films, the former about experimentation with death states and the latter dealing with terminal illness, Flawless has recovery as its central theme. However, the rehabilitation of Walt Koontz (Robert De Niro) after a serious stroke that paralyses his right side and renders him unable to speak does not entirely restore him to his former self. (Credit: MGM PICTURES) Identity … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif
Classification and identification of Pfiesteria and Pfiesteria-like species.
Authors: K Steidinger, J Landsberg, R W Richardson, E Truby, B Blakesley, P Scott, P Tester, T Tengs, P Mason, S Morton, D Seaborn, W Litaker, K Reece, D Oldach, L Haas, G Vasta
Journal: Environmental Health Perspectives (2001)

Dinoflagellates can be classified both botanically and zoologically; however, they are typically put in the botanical division Pyrrhophyta. As a group they appear most related to the protistan ciliates and apicomplexans at the ultrastructure level. Within the Pyrrhophyta are both unarmored and armored forms of the dominant, motile flagellated stage. Unarmored dinoflagellates do not have thecal or wall plates arranged in specific series, whereas armored species have plates that vary in thickness but are specific in number and arrangement. In armored dinoflagellates, the plate pattern and tabulation is a diagnostic character at the family, subfamily, and even genus levels. In most cases, the molecular characterization of dinoflagellates confirms the taxonomy on the basis of external morphology; this has been demonstrated for several groups. Together, both genetic and morphological criteria are becoming increasingly important for the characterization, separation, and identification of dinoflagellates species. Pfiesteria and Pfiesteria-like species are thinly armored forms with motile dinospore stages characterized by their distinct plate formulae. Pfiesteria piscicida is the best-known member of the genus; however, there is at least one other species. Other genetically and morphologically related genera, now grouped under the common names of "Lucy," "Shepherd's crook," and cryptoperidiniopsoid, are being studied and described in separate works. All these other heterotrophic dinoflagellate groups, many of which are thought to be benign, co-occur in estuarine waters where Pfiesteria has been found.
Invitro Antibodies: Strategies For Production And Application
Authors: S. Morrison
Journal: Annual Review of Immunology (1992)

The approaches to the production of antibodies (Ab) using the techniques of genetic engineering and expression are reviewed. Genetic engineering facilitates the production of proteins tailormade for an intended use. Bacterial and mammalian expression systems are commonly used for the production of Ab and Ab-like molecules. While genomic or cDNA cloning can be used to obtain the relevant variable regions, PCR-based cloning approaches facilitate the acquisition of additional binding specificities. Large numbers of different chimeric Abs with murine variable regions joined to constant regions from human and other species have been expressed and found to exhibit the expected binding specificities and effector functions. These molecules have been used to study the structural basis of effector functions such as complement activation and Fc receptor binding, and potentially they may be used as therapeutic agents. Carbohydrate has been shown to influence both variable and constant region function. Single-chain Abs and fusion proteins with Ab binding specificities joined to nonimmunoglobulin sequences provide a source of Ab-like molecules with novel properties, and genetically engineered Ab-like molecules provide a source of useful antigens. Combinatorial libraries produced in bacteriophage present an alternative to hybridomas for the production of Abs with desired combining specifities. Issues of the immunogenicity of the recombinant molecules are addressed.