tbuckley/cabot-search huggingface dataset:
Oral Vitamin K for Warfarin-Associated Coagulopathy
Authors: Elin Ringstrom, Heather Long
Journal: Annals of Internal Medicine (2003)

Letters1 April 2003Oral Vitamin K for Warfarin-Associated CoagulopathyElin Ringstrom, MD and Heather Long, MDElin Ringstrom, MDMt. Sinai Medical Center; New York, NY 10029 (Ringstrom)New York City Poison Control Center; New York, NY 10016 (Long)Search for more papers by this author and Heather Long, MDMt. Sinai Medical Center; New York, NY 10029 (Ringstrom)New York City Poison Control Center; New York, NY 10016 (Long)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-138-7-200304010-00029 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The work by Crowther and colleagues (1) on the use of oral vitamin K to treat warfarin-associated coagulopathy is thought-provoking, but several questions remain unanswered. In their study, patients' INRs were tested the day after study drug administration. The day after is an ambiguous phrase that may simply reflect a change in calendar day, not a 24-hour period. Whether patients had their INRs tested 6 hours or 24 hours after drug administration may significantly change the results. Almost twice as many patients in the oral group were inpatients (38%) compared with the subcutaneous group (20%). If the ...References1. Crowther MA, Douketis JD, Schnurr T, Steidl L, Mera V, Ultori C, et al. . Oral vitamin K lowers the international normalized ratio more rapidly than subcutaneous vitamin K in the treatment of warfarin-associated coagulopathy. A randomized, controlled trial. Ann Intern Med. 2002;137:251-4. [PMID: 12186515] LinkGoogle Scholar2. Hung A, Singh S, Tait RC. A prospective randomized study to determine the optimal dose of intravenous vitamin K in reversal of over-warfarinization. Br J Haematol. 2000;109:537-9. [PMID: 10886201] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Mt. Sinai Medical Center; New York, NY 10029 (Ringstrom)New York City Poison Control Center; New York, NY 10016 (Long) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoOral Vitamin K Lowers the International Normalized Ratio More Rapidly Than Subcutaneous Vitamin K in the Treatment of Warfarin-Associated Coagulopathy Mark A. Crowther , James D. Douketis , Terri Schnurr , Luigi Steidl , Valentina Mera , Carolina Ultori , Achille Venco , and Walter Ageno Oral Vitamin K for Warfarin-Associated Coagulopathy Mark A. Crowther Oral Vitamin K for Warfarin-Associated Coagulopathy Rick Weideman and Amit P. Patel Metrics 1 April 2003Volume 138, Issue 7Page: 610-611KeywordsCoagulopathyDrug administrationInpatientsInternational normalized ratioPatientsVitamin K ePublished: 1 April 2003 Issue Published: 1 April 2003 CopyrightCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Drug-Induced Hepatotoxicity
Authors: William M. Lee
Journal: New England Journal of Medicine (1995)

Drug-induced liver injury is a potential complication of nearly every medication that is prescribed, because the liver is central to the metabolic disposition of virtually all drugs and foreign substances.13 Although drugs are usually metabolized without injury to the liver, many fatal and near-fatal drug reactions occur each year. A few compounds produce metabolites that cause liver injury in a uniform, dose-dependent fashion.46 Most agents form a toxic byproduct only in rare persons. Injury to hepatocytes results either directly from the disruption of intracellular function or membrane integrity or indirectly from immune-mediated membrane damage. Factors promoting the accumulation . . .
INEBRIETY AMONG WOMEN IN THIS COUNTRY.
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Scrofulous Diseases of the External Lymphatic Glands: Their Nature, Variety, and Treatment
Authors: P. C. Price
Journal: BMJ (1860)

mental and physical exertion to which he was daily and hourly subjected in the discharge of the duties of his calling.CASE II.The head of a commercial firm in the City experienced suddenly an attack of cerebral congestion, and was in a state of insensibility when I first visited him, at 9 P.m.He had just returned home from ajourney; and it was apparent that his symptoms arose from gastric derangement.Three ounces of brandy, diluted with an equal quantity of hot water, were ordered to be administered; vesication was applied between the scapule; two grains of calomel, with four grains of rhtubarb, were ordered to be given directly; and effervescing medicine every four lhours, with an effervescing laxative in the morning.On my visit the following morning, sensibility was restored; the medicine had acted freely.Two ounces of brandy, with the same quantity of hot water, had been given twice in the night.In two or three days, this patient became convalescent.In this case, like the former, the patient was in the habit of living geinerously, conducting the chief part of the travelling departmiient, and taking moderately from one to two pints of ale, witlh a pint of ivine, dailv.Hence the rapid and safe con- valescence he experienced, owing chiefly to the cause (gastric disturbance) having been proomptly removed ; the conse- quences subsidinig in a few hours, vith the assistance rendered by Art to the restorative processes of Nature.CASE III.Several years since, I was requested to visit a case of hemiplegia.The patient, a female, aged about 48, of
Risk of ischaemic stroke in people with migraine: systematic review and meta-analysis of observational studies
Journal: BMJ (2005)

infarction with subsequent disability far more important than a short admission for acute coronary syndrome with rapid return to previous function.The answers to the other two questions are also negative.Hospital admissions occurred far more frequently than the two more important events (table ).Biological rationale fails to support a presumption that the invasive strategy will have similar effects on all three end points.Indeed, the investigators explicitly state that they expect an increase in short term deaths with surgery, while achieving benefits in terms of decreased angina and associated hospital admissions.The trend toward increased deaths, with a large reduction in admissions, with the invasive strategy provides support for this hypothesis.The composite end point thus fails all three criteria and provides little useful information for clinical decision making.
General surgery
Authors: E. R. Hirvela
Journal: JAMA (1994)

The happy cohabitation of surgery with basic science has experienced another productive year. Basic science research is not easily translated into clinical usefulness. The downsizing of federal funding and the increasing participation of the biomedical-industrial complex has affected surgical research. New diagnostic modalities in the panoperative setting have seen increasing application within the last year that affects the volume, type, and extent of future operations. The widespread application of screening mammography has led to an increase (up to sixfold) in the number of open breast biopsies performed for mammographic abnormalities. Most such radiologic findings correspond to benign processes, but the cost to prove benignancy is substantial. Stereotactic automated core breast biopsy is a method of precisely directed tissue sampling that can be performed with the patient under local anesthesia. Comparison of tissue diagnosis using this technique followed by open biopsy in a study of 98 lesions showed a high correlation.
PRESENT STATUS OF OUR KNOWLEDGE OF FATTY DEGENERATION.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reference Manager
Authors: ROBERT J. PANZER
Journal: Annals of Internal Medicine (1985)

Software1 January 1985Reference ManagerROBERT J. PANZER, M.D., MARK E. WILLIAMS, M.D.ROBERT J. PANZER, M.D.Search for more papers by this author, MARK E. WILLIAMS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-102-1-144 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptChoosing a bibliographic reference management system is not a simple task. The least expensive strategy is to modify a general purpose database system. However, this approach requires additional effort in designing a format appropriate for filing and retrieving references. Special programs dedicated to managing references can be used immediately and often provide a variety of special functions.Reference Manageris such a dedicated database system. It allows one to enter references directly from the keyboard or from a text file containing references downloaded from MEDLINE or COLLEAGUE (using its Capture module). Several users can maintain their own files. The... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ROBERT J. PANZER, M.D.; MARK E. WILLIAMS, M.D.Affiliations: University of Rochester School of Medicine and Dentistry Rochester, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byReview of Reference ManagerERNEST BEUTLER, M.D.Correction: Vendor Information for Reference Manager 1 January 1985Volume 102, Issue 1Page: 144-145KeywordsDatabases ePublished: 1 December 2008 Issue Published: 1 January 1985 PDF downloadLoading ...
Trace Metals Speciation by HPLC with Plasma Source Mass Spectrometry Detection
Authors: Francine A. Byrdy, Joseph A. Caruso
Journal: Environmental Health Perspectives (1995)

The analysis of environmental and biological samples often requires detection at the parts per billion (ppb) level.Plasma source mass spectrometry has potential as a method for the analysis and speciation of trace elements.This is due to the technique's highly selective nature and excellent sen- sitivity.In comparison to atomic emission detection, detection limits are usually two to three orders of magnitude lower for plasma MS determina- tions.Interfacing HPLC with plasma MS provides a means of separation that is necessary for speciation.Speciation involves the determination and quantitation of the various chemical forms of a particular element.A host of HPLC-ICP-MS techniques may be used to obtain this information.This brief report will focus on the most recent work in this area, with emphasis on the work done in our laboratory.-
Defects in DNA repair genes and sensitivity to cisplatin based neoadjuvant chemotherapy (NAC) for bladder cancer.
Authors: Yu-Ning Wong, Roland Dunbrack, Tim Brennan, Mark D. Andrake, Yan Zhou, Ilya Serebriiskii, Essel Dulaimi, Jean H. Hoffman-Censits, Marijo Bilusic, Alexander Kutikov, Rosalia Viterbo, Richard Evan Greenberg, David Y. T. Chen, Costas D. Lallas, Edouard John Trabulsi, Roman Yelensky, Vincent A. Miller, Erica Golemis, Eric A. Ross, Elizabeth R. Plimack
Journal: Journal of Clinical Oncology (2015)

4514 Background: Cisplatin based NAC prior to cystectomy is standard of care for MIBC, with 40-50% expected to respond with ≤ pT1N0M0. Biomarkers predictive of response are lacking. Methods: MIBC pts who received 3 cycles of cisplatin based NAC on 1 of 2 prospective multicenter clinical trials were included. Pts treated with accelerated methotrexate, vinblastine, doxorubicin + cisplatin (AMVAC) provided the discovery set [n = 34, 15/34 (44%) ≤ pT1N0M0]. Pts treated with dose dense gemcitabine + cisplatin (DDGC) provided the validation set [n = 24, 11/24 (46%) ≤ pT1N0M0]. DNA from pre-treatment tumor tissue underwent sequencing for all coding exons of 287 cancer-related genes and was analyzed for presence of base substitutions, indels, copy number alterations, and selected re-arrangements. The mean number of variants and variant status for each gene were correlated with response using two-sample t-test and Fisher’s exact tests. Variant data were used to create a classification tree to discriminate responders vs. non-responders in the AMVAC discovery cohort. The resulting decision rule was then tested in the independent DDGC validation set. Overall survival analysis was performed using Kaplan-Meier. Results: Pts with pT0 had significantly more alterations than those with residual tumor in both the AMVAC discovery (p = .024) and DDGC validation (p = 0.018) set. In the AMVAC discovery set, alteration in ≥ 1 of the three DNA repair genes ATM, RB1 or FANCC predicted for ≤ pT1N0M0 (p < 0.001, 87% sensitivity, 100% specificity) and improved overall survival (OS) (p = 0.007). This test remained predictive for ≤ pT1N0M0 in the DDGC validation set (p = 0.033), with a trend towards improved OS (p = 0.055) at short median follow up of 16.75 mo. Conclusions: Alterations in ≥ 1 of ATM, RB1 and FANCC predict response to cisplatin based chemotherapy defined as ≤ pT1N0M0 in both our AMVAC discovery and DDGC validation sets. We hypothesize that defects in these genes, which are important for maintenance of chromatin structure and DNA repair, confer sensitivity to DNA damaging chemotherapy and explain the accumulation of alterations seen among pts with pT0. Further validation is planned.
What Is Internal Medicine?
Authors: Michael A. LaCombe
Journal: Annals of Internal Medicine (1993)

Letters15 September 1993What Is Internal Medicine?Michael A. LaCombe, MDMichael A. LaCombe, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-6-199309150-00042 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:As I immersed myself in Dr. LaCombe's article [1], I thought that I had not only found a friend but an excellent spokesperson for our specialty. All the more my disappointment when this early superb exposition of my innermost thoughts degenerated into an unfortunate physician-splitting diatribe pitting the struggling and poorly paid generalist against the know-it-all and overcompensated internal medicine subspecialists!For us rheumatologists, data show that subspecialty training has a negative impact on income [2]. Thus, I take issue with the generalization that the use of my services is a much more expensive, less personal route ...References1. LaCombe M. What is internal medicine? Ann Intern Med. 1993; 118: 384-7. Google Scholar2. Prashker MJ, Meenan RF. Subspecialty training: is it financially worthwhile? Ann Intern Med. 1991; 115:715-9. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 September 1993Volume 119, Issue 6Page: 541-542KeywordsAntinuclear antibodiesHeartLiverMusclesMyalgiaPacemakersPainPatientsSub-specialty careThallium ePublished: 15 August 2000 Issue Published: 15 September 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Radiation and the World We Live In
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A phase II, open-label, multi-arm study of TAS-115 for castration-resistant prostate cancer patients with bone metastases.
Authors: Hiroji Uemura, Nobuaki Matsubara, Hirotsugu Uemura, Satoshi Nagamori, Hiroyoshi Suzuki, Go Kimura
Journal: Journal of Clinical Oncology (2019)

164 Background: TAS-115, a novel multi-kinase (eg, MET, VEGFR) inhibitor has also shown to inhibits Feline McDonough Sarcoma oncogene (FMS) kinase, Anti-tumor activity against bone metastases was observed in the preclinical and phase1 study. In this phase 2 study, the efficacy and safety of TAS-115 were evaluated in castration-resistant prostate cancer (CRPC) patients (pts) with bone metastases. Methods: This was a phase 2, open-label, multi-arm study for CRPC pts with bone metastases to evaluate the clinical anti-tumor activity of TAS-115. Pts who had visceral metastases were ineligible for this study. TAS-115 was given orally, once daily, and schedule of 5 days on/2 days off each week was repeated. This study had 2 cohorts (A and B). In cohort A, TAS-115 ranging from 200 to 400 mg/day with abiraterone acetate was given to pts prior to docetaxel. In cohort B, CRPC pts who had symptomatic bone metastases, post or unfit to docetaxel, were randomized in a 1:1 to 400 or 600 mg/day of TAS-115. The primary endpoint was bone scan index (BSI) response rate at week 12, defined as ≥ 30% decrease of BSI from baseline. BSI is a quantitative assessment of bone scan data calculated by software (BONE NAVI). Results: From Nov 2016 to Jul 2018, a total of 50 pts received TAS-115 (24 pts in cohort A and 26 pts in cohort B). BSI response rate at week 12 and best BSI response was 20.8 % and 37.5% in cohort A, and 15.4 % and 19.2% in cohort B, respectively. Any reduction of BSI was observed in 70.8% of cohort A and 61.5% of cohort B. In cohort B, pain was assessed using the Brief Pain Inventory short form and improvement was observed in 61.5% of pts. Furthermore, the reduction of bone-turnover marker (BAP, P1NP, NTx and TRACP-5b) were observed in both cohorts, but not PSA response. The major (≥ 10%) Grade 3/4 treatment-related adverse drug reactions were hypophosphataemia (21%) in cohort A, and anemia (23%), hypophosphataemia (12%) and neutrophil count decreased (12%) in cohort B. Conclusions: Preliminary anti-tumor activity to bone lesion and improved pain were observed in CRPC pts with bone metastases, and safety of TAS-115 was acceptable. TAS-115 could be a novel therapeutic agent with a favorable safety profile for CRPC with bone metastases. Clinical trial information: JapicCTI-163448.
Infrequent defecation in children
Authors: C. A. Conn
Journal: JAMA (1987)

<h3>In Reply.—</h3> Dr Smith describes the dilemma of concerned family and general practitioners regarding mental morbidity in the older patient. He counsels very strongly that training and other approaches intended to increase skills of these practitioners are essential. In this, he shares the concern that motivated the study reported in the Jan 23/30 issue of<i>JAMA</i>, which concludes with the opinion that some strategy aimed at helping the family practitioner is necessary. The General Health Questionnaire, which was used in our study, may not be the most effective strategy, and certainly more investigation is indicated. Better designed and targeted training as well as interventions to increase the awareness of clinicians are both indicated. We join Dr Smith in calling attention to the fact that the elderly do have psychological and emotional problems requiring attention.
Thérapeutique chirurgicale ophtalmologique.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal