tbuckley/cabot-search huggingface dataset:
Correction: Control of meningococcal disease
Authors: Julia Archivist, Julian Hart
Journal: BMJ (1989)

to buy their homes, but local authorities are entitled to use only a quarter of the capital receipts from house sales and half of those from land sales for new building.The government also restricts how much local authorities can borrow to pay for renovations and building.These policies are leading to a remorseless reduction of public housing stock and a deterioration in its quality.It costs up to £24 000 a year to place a family of three in bed and breakfast accommodation in London.In 1987 it was twice as expensive to keep a family in bed and breakfast accommodation as to provide a new council flat.As the report says, "Homes are cheaper than homelessness."It must be time to recognise these humanitarian and economic arguments and start investing in public housing.
THE MELTZER-LYON METHOD IN THE DIAGNOSIS OF INFECTIONS OF THE BILIARY TRACT
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Randomized multicenter phase III trial comparing two neoadjuvant chemoradiotherapy (CT-RT) regimens (RT45-Cap versus RT50-Capox) in patients (pts) with locally advanced rectal cancer (LARC): Results of the ACCORD 12/0405 PRODIGE 2
Authors: J. Gerard, D. Azria, S. Gourgou-Bourgade, I. Martel-Laffay, C. Hennequin, P. Etienne, V. Vendrely, T. Conroy, E. Francois, C. Montoto-Grillot
Journal: Journal of Clinical Oncology (2009)

LBA4007 Background: Following the results of randomized trials FFCD 9203 and EORTC 2291, neoadjuvant CT-RT is considered standard treatment for LARC. The ACCORD 12/0405 PRODIGE 2 trial was initiated to optimize this regimen. Methods: Pts with T3 or resectable T4 N0–1-2 M0, rectal adenocarcinoma were randomized to arm A: concurrent RT 45Gy/25f/5 weeks (w) + capecitabine (800mg/m 2 /bid) or arm B: concurrent RT 50Gy/25f/5w + capecitabine (800mg/m 2 /bid/5/7days) + oxaliplatine 50mg/m 2 /w. Resection with Total Mesorectum Excision was scheduled 6 weeks after the end of CT-RT. Adjuvant chemotherapy was optional. 590 patients were needed to show an increase in the pathological complete response (Dworak) rate from 11% (arm A) to 20% (arm B). Circumferential positive rectal margin (CRM R1) was defined as the presence of residual cancer cells within 0 to 1 mm from the perirectal surface. Results: This trial closed in 07/2008 after randomization of 598 pts since 11/2005. Patients characteristics of 586 eligible pts were well balanced: male 66%, median age 61 years, 66% low rectum, 87% T3 stage. Data base was locked in March 2009. Results are reported in Table . Conclusions: The RT 50 capox regimen is compatible with surgery in 98% of cases with no increase in postoperative complication. In the RT 50 arm, there is a trend in favour of a higher rate of pathological complete sterilization and lower rate of positive CRM. These data could contribute to design a new standard preoperative regimen for LARC. 50 Gy/25 F/5 weeks combined with concurrent chemotherapy could be proposed as an efficient schedule. [Table: see text] No significant financial relationships to disclose.
THE CENTENARY OF THE BIRTH OF LORD LISTER
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tumor necrosis factor up-regulates expression of low-density lipoprotein receptors on HepG2 cells
Authors: W Liao
Journal: Hepatology (1993)

Tumor necrosis factor mediates most biological activities of endotoxin and also, in part, mediates endotoxin-induced disturbances in lipid metabolism. In this study, the effect of tumor necrosis factor on low-density lipoprotein receptor activity was investigated in cells of HepG2, a well-differentiated human hepatoma cell line. Pretreatment of the cells with tumor necrosis factor leads to enhanced binding, uptake and degradation of 125I-labeled low-density lipoprotein. This effect of tumor necrosis factor was dose and time dependent. Tumor necrosis factor-stimulated enhancement of low-density lipoprotein binding occurred at all stages of cell growth. However, addition of an excess of unlabeled low-density lipoprotein, to down-regulate low-density lipoprotein receptors before exposure to tumor necrosis factor of the cells, completely abolished the effects of tumor necrosis factor. Competition experiments using unlabeled low-density lipoprotein and blockage experiments with a monoclonal low-density lipoprotein receptor antibody showed that tumor necrosis factor-stimulated low-density lipoprotein binding takes place through stimulation of low-density lipoprotein receptors. Comparison of the kinetics of specific low-density lipoprotein binding in the unstimulated cells and in the tumor necrosis factor-stimulated cells indicated that tumor necrosis factor caused a 30% increase in maximum velocity with no significant change in Michaelis constant, suggesting that tumor necrosis factor increases the number of low-density lipoprotein receptors on the cells rather than changing binding affinity. Preincubation of the cells with cycloheximide or actinomycin D totally abolished the up-regulatory effect of tumor necrosis factor on low-density lipoprotein receptors. Tumor necrosis factor did not stimulate proliferation of HepG2 cells, as judged by cell protein determination or by [3H]thymidine incorporation. In conclusion, this study suggests that tumor necrosis factor up-regulates expression of low-density lipoprotein receptors on HepG2 cells by stimulation of de novo synthesis of receptors, independent of cell growth. (HEPATOLOGY 1993;17:898–907.)
Pain Management
Authors: Ronald Kanner
Journal: JAMA (1986)

Three major areas have advanced in our management of pain patients: (1) better syndrome definition, (2) clearer scientific basis for the use of analgesic medications, and (3) correct utilization of pain centers. Acute pain<sup>1</sup>is linked in time, location, and severity to an underlying lesion. Chronic pain can be divided into nociceptive (related to tissue injury) and non-nociceptive (deafferentation and psychogenic).<sup>2</sup><i>Nociceptive</i>pain is the most common type in cancer and other medical illness. It most often responds to treatment of the underlying cause or to standard analgesic medication.<i>Deafferentation</i>pain<sup>3</sup>is due to nervous system injury that interrupts the normal transmission of sensory impulses. Pain is ill-defined, burning, and dysesthetic and may have a component of sympathetic dysfunction with wasting, color changes, shiny skin, decreased temperature, and hair loss. If the sympathetic component is prominent, sympatholytic procedures may be indicated. Reflex sympathetic dystrophy and postherpetic neuralgia
Glomerular lesions in sickle cell nephropathy
Authors: B. R. Walker
Journal: JAMA (1971)

Nine patients with sickle cell anemia (SS) and four with sickle cell trait (AS) were studied for evidence of nephropathy. Two of the SS patients died with uremia, and three others had proteinuria, including one with the nephrotic syndrome. With light microscopy, eight SS patients were found to have anatomical changes similar to those caused by a proliferative glomerulonephritis, whereas the AS patients were found to have no significant abnormalities. In cases of SS, renal function tests did not reflect the degree of pathological glomerular disease. Anatomical abnormalities seemed to correlate with the number of sickle cell crises, and may have been due to renal arteriolar ischemia. Previous reports of SS histology have not emphasized glomerular changes. It is postulated that, as the life span of SS patients increases, clinical evidence of glomerular disease will be seen more frequently.
CODE OF MEDICAL ETHICS.
Journal: JAMA (1884)

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LAY MOVEMENTS FOR THE IMPROVEMENT OF PUBLIC HEALTH
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Vitamin C prophylaxis in marine recruits
Authors: H. A. Pitt
Journal: JAMA (1979)

A prospective, randomized, double-blind study was carried out to determine whether vitamin C prophylaxis, 2.0 g/day, vs placebo prophylaxis would reduce the incidence or morbidity of the common cold and other respiratory illnesses in 674 marine recruits during an eight-week period. Whole-blood ascorbic acid levels measured six weeks after initiation of the study were significantly higher in the vitamin C group. There was no difference between the two groups in the incidence or duration of colds. The vitamin C group rated their colds as being less severe, but this was not reflected in different symptom complexes or in fewer sick-call visits or training days lost. This study and the literature do not support the prophylactic use of vitamin C to prevent the common cold. (<i>JAMA</i>241:908-911, 1979)
A multicentre audit of hospital referral for radiological investigation in England and Wales. Royal College of Radiologists Working Party.
Authors: P Bourdillon, P Camm, A Cohen, E Davies, W Ennis, K Evans, P Hacking, M Lavelle, J Laws, M Mcnulty, C Roberts, G Roberts, G Row, R Sutherland, J Williams
Journal: BMJ (1991)

A baseline audit of radiology referral practice before the introduction of a strategy for change involving guidelines of good practice, monitoring, and peer review.Prospective data collection over a continuous 12 months period at each centre sometime between January 1987 and December 1989.Five district general hospitals and one district health authority.159,421 inpatient discharges, deaths, and day cases and 861,370 outpatient attendances under the care of 722 consultants from 25 clinical specialties.Monitoring of x ray examination referrals per 100 inpatient discharges, deaths, and day cases and per 100 new outpatient attenders after establishment of a computerised data collection system.Referral rates for all x ray examinations varied between firms in the same specialty or sub-specialty by as much as eightfold for inpatients and 13-fold for outpatients, and for chest x ray examination by as much as ninefold for inpatients and 25-fold for outpatients. There was no consistent relation between high referral and teaching status of the centre or specialty or subspecialty.The variation that persisted at all levels of disaggregation of the data supports a recent suggestion that at least a fifth of x ray examinations carried out in Britain may be clinically unhelpful. An intervention study that examines the effect of guidelines of good practice and attendant peer review procedures on the baseline referral levels described above is needed to test this hypothesis further.
INDIA AND THE COLONIES
Journal: BMJ (1903)

UDICA 6'Jiz II, and 6 in the three preceding weeks.The number of scarlet fever cases in these hospitals and in the London Fever Hospital on Saturday last, the 12th inst, was 1,772, against 1,797. 1,774.and I,796 on the three preceding Saturdays; 212 new cases were admitted during last week, against 225, 199, and 229 in the three preceding weeks.HEALTH OF SCOTCH TOWNS.DuRING the week ending Saturday last, September 12th, 892 births and 47o deaths were registered in eight of the principal Scotch towns.The annual rate of mortality in these towns, which had been 15.1, 15.I, and i6.6 per i,ooo in the three preceding weeks, declined again last week to 14.4 per i,ooo, and was I .4 per I,ooo below the mean rate during the same period in the seventy-six large English towns.Among these Scotch towns the death-rates ranged from 8.5 in Leith and 12.7 in Edinburgh, to I8.9 in Paisley and 20.1 in Perth.The death-rate from the principal infectious diseases averaged 2.4 per I,ooo in these towns, the highest rates being recorded in Dundee and Perth.The 225 deaths registered in Glasgow included 5 from measles, 7 from whooping-cough, 3 from "fever," and 21 from diarrhoea.Ten fatal cases of diarrhoea and 4 of " fever" occurred in Dundee; g of diarrhoea in Edinburgh, 6 in Aberdeen, 3 in Greenock, and 2 in Paisley.HEALTH OF' IRISH TOWNS.DURING the week ending Saturday, September 12th, 456 births and 298 deaths were registered in six of the principal Irish towns, both items being considerably below the average of foregoing periods.The mean annual death-rate of these towns, which had been 19.2, 18.2, and x6.5 per I,000 in the three preceding weeks, fell slightly to 16.2 per i,ooo during the week under notice, this figure being 0.4 over the mean annual rates during the corresponding period in the seventy-six English towns.The death-rates ranged in these six Irish towns from 6.8 in Limnerick, and 14.4
Leads from the MMWR. Premature mortality in New Hampshire
Journal: JAMA (1988)

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Correspondence
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Carcinoma of the Breast
Authors: Francis D. Moore, Steven I. Woodrow, Menelaos A. Aliapoulios, Richard E. Wilson
Journal: New England Journal of Medicine (1967)

Adrenalectomy and HypophysectomyAcceptability of Surgical Palliation – Overall Success RateAlthough the fractional incidence of palliative success appears to be about the same for hormone therapy and an unselected series of adrenalectomies or hypophysectomies, it has been a virtually universal experience, and certainly that of our group, that the operations provide a longer and more complete respite from the disease in the patients who do respond favorably.Even though the response to palliative treatment can be graded according to objective remissions, these criteria are not the only ones that affect the value judgments of patient and doctor. Many patients . . .
Transactions of Pathological Society of Philadelphia.
Journal: JAMA (1898)

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Highlights
Journal: JAMA Internal Medicine (2018)

In this study, Moore and colleagues estimated the costs of pivotal clinical trials for all new therapeutic agents approved by the US Food and Drug Administration from 2015 to 2016 and examined how key features of the pivotal trials were associated with these costs.A total of 138 pivotal clinical trials provided the basis for approval of 59 new therapeutic agents, with a median estimated cost of $19 million.Results showed pivotal clinical trial costs increased if more patients were needed to document treatment benefit, if active drug comparators were used, or to measure clinical end points rather than a change in a surrogate outcome.Ross provides the Editor's Note.
PLAGIARISM EXTRAORDINARY.
Journal: JAMA (1899)

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