tbuckley/cabot-search huggingface dataset:
Personalized multimodality therapy with immune checkpoint inhibitors (ICI), chemotherapy (CT), and targeted treatment (TT) in advanced refractory cancer.
Authors: Philip A. Salem, Khaled W. Jabboury, Randall Stenoien, Thomas M. Wheeler, Maria Rosaria Valerio
Journal: Journal of Clinical Oncology (2019)

e14254 Background: Therapy for advanced refractory malignancies remains a major challenge. As the combination of ICI and CT has been shown in some cancers to be superior to CT alone, and as ICI, CT, and TT have efficacy, but divergent toxicity; this combination was chosen for treating patients with such diseases. Methods: Treatment was highly personalized and was designed based on diagnosis, prior therapy and eligibility for TT. ICI included pembrolizumab in 7 (2 in combination with ipilimumab), nivolumab in 10, and atezolizumab in 2. Chemotherapy was given in 28-day cycles. Multiagent CT cycles were given in 17, and single-agent in 2.13 received platinum and 10 taxanes. TT included erlotinib 4, cituxumab 2, bevacizumab 2, dabrafenib/trametinib 3, crizotinib 1, alectinib 1, sorafenib 1, everolimus 1. 4 were not eligible for TT. Results: From 04/2016 to 10/2018 19 consecutive patients (PT) were treated; median (M), age 62 (27-82), ECOG PS 2 (0-4), female 15/male 4. Tumor type; lung 8, pancreas 3, lymphoma 2, melanoma 2, cholangioCA 1, ureter 1, cervix 1, Glioblastoma Multiforme 1. 13 PT had prior therapy, M2(1-11). 7 had prior ICI, 3 prior TT. Disease was bulky in 6. Response was based on PET evaluation with tumor regression depicted after cycle #1. 11 achieved CR (57%), M 6 + months (1 + -15 + ), 7 PR (37%), M 4 months (1 + -7) and 1 SD 7 months. 3 intracranial metastases; 2 CR, 1 PR. Response was seen in extensive prior therapy, bulky disease, poor performance, and prior ICI. No unexpected side effects were observed. Grade 3-4 adverse events; 12.7%, primarily hematologic. Conclusions: The personalized combination of ICI, CT, and TT in advanced refractory diverse cancer diseases is associated with high clinical activity. Further evaluation in clinical trials is strongly indicated.
Erratum
Journal: BMJ (1900)

The matter of the French railway concession referred to by our correspondent was brought under the notice of the various English railway companies in May, and they agree in stating that it is of little, if any, value to British travellers.The excursion fares to Paris are so small that the price of a single ticket to Paris added to the single fare from the frontier town back to England amounts to the same, if not to a larger sum of money than the cheap ticket.There are the additional inconveniences of being unable to register the luggage through and of having to take separate tickets.The German rairways are
Association between nutritional status and cognitive functioning in a healthy elderly population
Authors: J. S. Goodwin
Journal: JAMA (1983)

We evaluated the association between nutritional status and cognitive functioning in 260 noninstitutionalized men and women older than 60 years who had no known physical illnesses and were receiving no medications. Nutritional status was evaluated by three-day food records and also by biochemical determination of blood levels of specific nutrients. Cognitive status was evaluated by the Halstead-Reitan Categories Test (a nonverbal test of abstract thinking ability) and by the Wechsler Memory Test. Subjects with low blood levels of vitamins C or B<sub>12</sub>scored worse on both tests. Subjects with low levels of riboflavin or folic acid scored worse on the categories test. These differences remained significant after controlling for age, gender, level of income, and amount of education. "Subclinical" malnutrition may play a small role in the depression of cognitive function detectable in some elderly individuals, or depressed cognitive function may result in reduced nutrient intake. (<i>JAMA</i>1983;249:2917-2921)
THE RÔLE OF OXYGEN AND HEAT PRODUCTION IN THE FUNCTION OF MUSCLES
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Blackwater Fever
Journal: Annals of Internal Medicine (1928)

Article1 October 1928Blackwater FeverEUGENE R. WHITMORE, M.D., D.P.H.EUGENE R. WHITMORE, M.D., D.P.H.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-2-4-316 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt is not my intention, and it is not necessary, to go into a general discussion of blackwater fever; and I have already discussed the general problem of hemoglobinuria elsewhere. I do want to stress the importance of examining the urine chemically for hemoglobin, and microscopically for hemoglobin casts and red blood cells, to be sure to differentiate hemoglobinuria from hematuria―two entirely different conditions. I also want to stress the point that, especially after the patient has vomited a few times, the vomitus in blackwater fever contains bright green flecks and shreds of mucus, and the liquid portion of the...* CIAVALDINI J: Un cas d'hemoglobinurie chez une paludienne n'ayant jamais absorbe de quinine. Arch. l'Inst. Past. de Algerie, 1927, v, 48. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Georgetown University Washington, D. C.*Read before the American College of Physicians, New Orleans, Clinical week, March 9, 1928. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1928Volume 2, Issue 4Page: 316-324KeywordsFeversHemoglobinMucusRed blood cellsUrine ePublished: 1 December 2008 Issue Published: 1 October 1928 PDF downloadLoading ...
Management of oral lichen planus
Authors: S. Porter, C. Scully
Journal: British Journal of Dermatology (2000)

SIR, Dr Graham‐Brown’s editorial comments regarding the potential efficacy of low molecular weight heparin in the management of lichen planus1 highlight the difficulties of managing oral lichen planus and the need for detailed studies of the management of this often painful chronic disorder. Oral lesions appear far more recalcitrant than do cutaneous lesions. For example, data from our unit strongly indicate that oral lichen planus is a very chronic disorder in U.K. patients. A retrospective analysis of 690 patients with oral lichen planus, some of whom had attended for up to 22 years, revealed that only 13% had remission of disease. It is evident that many U.K. patients have protracted, sometimes almost lifelong, signs and/or symptoms of oral lichen planus. There is thus a need to undertake detailed, well‐controlled studies of potentially useful therapies of this troubling disorder.
Delayed menarche and amenorrhea of college athletes in relation to age of onset of training
Authors: R. E. Frisch
Journal: JAMA (1981)

Age at menarche and menstrual periodicity of 21 college swimmers and 17 runners were studied in relation to the age of initiating training. The 18 premenarche-trained athletes had a mean menarcheal age of 15.1±0.5 years, whereas the 20 postmenarche-trained athletes had a mean menarcheal age of 12.8±0.2 years, similar to that of the college control subjects, 12.7±0.4 years. Each year of training before menarche delayed menarche by five months (0.4 years). Of the premenarche-trained athletes, 61% had irregular menstrual cycles and 22% were amenorrheic, whereas 60% of the postmenarche-trained athletes had regular menstrual cycles and none were amenorrheic. Training increased the incidence of oligomenorrhea and amenorrhea among both premenarche- and postmenarche-trained athletes. Metabolic and hormonal changes consequent to an increased lean/fat ratio may explain these findings. (<i>JAMA</i>1981;246:1559-1563)
Outcomes for Patients With Stroke in Managed Care vs Fee-for-Service
Authors: Michael J. Barber
Journal: JAMA (1997)

<h3>To the Editor.</h3> —As a physician concerned about patient outcomes in the changing Medicare market place, I was interested in the article by Dr Retchin and colleagues.<sup>1</sup>However, close review of the article and the accompanying Editorial<sup>2</sup>greatly disappointed me. How the authors can boldly portray this to be a study comparing outcomes of stroke patients in managed care and FFS care systems based on 8-year-old data coming primarily from 2 states, measuring only 2 outcomes and 1 element of the process of care, is beyond my comprehension. When the authors failed to demonstrate any difference in 2 of the outcomes measured—death and rehospitalization—they assembled snippets of data from other studies designed to compare other outcomes and managed to infer that stroke care in the managed care setting is inferior. Moreover, Drs Webster and Feinglass chose to ignore half of the outcomes in this study (no difference in survival), the severe
Anticancer chemotherapy.
Authors: P Davey, G R Tudhope
Journal: BMJ (1983)

Though the selection and administration of cytotoxic drugs is usually restricted to specialist units, all doctors should be aware of both the available treatment and its associated problems.This review concerns new cytotoxic drugs and some new applications of current drugs.It is largely confined to drugs marketed in the United Kingdom in the past five years and drugs from abroad that are currently used in the United Kingdom, although some mention is made of those still undergoing clinical trial which may be more widely used in the future.Many new drugs are analogues: they are the product of a search for a compound related to an existing cytotoxic drug that will retain or surpass its efficacy with a simultaneous reduction in toxicity.Current drugs and their analogues ALKYLATING AGENTS Alkylating agents-for instance, busulphan, cyclophospha- mide, melphalan, and mustine-prevent replication of nucleic acids by cross linking base pairs.Doses of all alkylating agents are limited by myelosuppression and gastrointestinal disturbance; haemorrhagic cystitis is dose limiting for cyclophosphamide.ANALOGUES OF ALKYLATING AGENTS Ifosfamide (Mitoxana) is structurally related to cyclophos- phamide.It may have better activity against non-small cell lung cancer and soft tissue sarcoma, but otherwise there is no convincing evidence of superiority over cyclophosphamide.Gastrointestinal side effects and haemorrhagic cystitis seem to be more severe than after cyclophosphamide but this may be related to differences in dose rather than in biological activity.Disturbances of consciousness have been reported after ifosfamide.Treosulfan (Treosulfan Leo) is a derivative of busulphan used to treat ovarian cancer.Like busulphan it is myelo- suppressive and causes skin pigmentation.
Change in Policy.
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Improved Method of Direct Cannulation of the Carotid Artery for Infusion
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SANITARY CONSIDERATION OF HEALTH RESORTS
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nontraumatic Mediastinitis
Authors: Robert W. Enquist
Journal: JAMA (1976)

ACUTE mediastinitis is distinctly uncommon; when it occurs, it usually follows an esophageal perforation or median sternotomy incision during open heart surgery. Nontraumatic causes include infections of the upper respiratory tract, infections of the lung and pleura, subphrenic infections, vertebral and rib osteomyelitis, and metastatic infections. These latter conditions may initially present as acute mediastinitis, requiring prompt and vigorous treatment as well as a thorough search for the underlying cause. This communication describes a case of nontraumatic acute mediastinitis and reviews the literature pertaining to the bacteriologic spectrum and treatment of mediastinitis of nontraumatic origin. <h3>Report of a Case</h3> A 64-year-old man in previously good health had the onset of fever, myalgia, sore throat, and malaise. Three days later, because persistent substernal chest pain developed, he was seen as an outpatient and pharyngitis was noted. His chest roentgenogram and complete blood cell count were unremarkable. No cultures were done, and
Empirical carbapenem versus third-generation cephalosporin treatment for spontaneous bacterial peritonitis: a multicenter study
Authors: Sun Woong Kim, Jun Yong Park, Yong Jin Jung, Jeonghoon Lee, Jae Seung Lee, Jisoo Song, Han Ah Lee, Yeon Seok Seo, Minjong Lee, Dae Hee Choi, Moon Young Kim, Seong Hee Kang, Jin Mo Yang, Do Seon Song, Jun Sik Yoon, Minseok Albert Kim, Hyunwoo Oh, Heejoon Jang, Cheol-Hyung Lee, Sungwon Chung, Yun Bin Lee, Eun Ju Cho, Su Jong Yu, Yoon Jun Kim, Jung-Hwan Yoon
Journal: Journal of Hepatology (2020)
A NEW CONCEPTION OF GLYCOGEN FORMATION
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Les Glandes Endocrines et Leur Valeur Fonctionnelle.
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
New findings in diabetic retinopathy
Authors: W. A. Check
Journal: JAMA (1981)

"Tight" control of blood glucose shows promise for reducing the visual complications of juvenile diabetes, according to preliminary results of two studies presented at the recent meeting of the American Academy of Ophthalmology in Atlanta. One investigator stressed, however, that he saw no "miraculous" reversals of diabetic retinopathy in patients receiving continuous insulin injections from a portable pump. This is in conflict with several recent case reports of such regression. In another report also dealing with the visual complications of diabetes, ophthalmologic surgeons from the Bascom-Palmer Eye Institute in Miami described several factors that influence the outcome of vitrectomy carried out to remove vitreous opacities in retinopathic eyes. Until the results of a recently begun investigation become available, their retrospective analysis of 1,500 cases provides the best current guidelines for determining which patients have the greatest chance of benefiting from this procedure. <h3>Glucose Control.—</h3> There long has been a dispute
CHANGE OF OCCUPATION DOES NOT DISQUALIFY AN EXPERT WITNESS.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal