tbuckley/cabot-search huggingface dataset:
‘Clear-ability' and Clarity in Medical Writing
Authors: Niranjan Kissoon
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical and molecular characteristics of non-small cell lung cancer in patients harboring <i>CTNNB1</i> mutations.
Authors: Leonie Gogl, Matthias Scheffler, Ihle Michaela, Sebastian Yves Friedrich Michels, Rieke Fischer, Monika Heidi Serke, Ulrich Gerigk, Claudia Wompner, Stefan Krüger, Britta Kaminsky, Wolfgang Schulte, Gert Höffken, Sabine Merkelbach-Bruse, Reinhard Büttner, Juergen Wolf
Journal: Journal of Clinical Oncology (2015)

8098 Background: Although somatic mutations of CTNNB1 in lung cancer have been described, there is still lack of information about prevalence, genetic variability, occurrence of additional aberrations and influence on outcome. This study was performed to analyze CTNNB1mutations in NSCLC genetically and clinically. Methods: Tumor tissue collected from 3885 patients within a regional screening network was analyzed for CTNNB1 mutations using next generation sequencing (NGS). Clinical, pathological and genetic characteristics of these patients are described and compared with a control group of patients without CTNNB1 mutation. Results: We have identified 58 (1.5%) CTNNB1-mutated patients, whereof 51 have been analyzed so far. This cohort consisted of 32 female and 19 male patients. Adenocarcinoma histology was found in 42 patients (82.4%), but CTNNB1 mutations were also found in squamous cell and neuroendocrine carcinomas. 21 different CTNNB1 mutations were detected on exon 3, of which most are miss-sense mutations (49) besides 2 deletions. The most frequent mutations were S37F and S37C substitutions which each occurred in nine patients. Exclusive CTNNB1 mutations were only detected in five patients. In all remaining patients an additional driver mutation was found including mutations in KRAS, EGFR, BRAF, AKT, PIK3CA and ERBB2 as well as MET amplification, RET-KIF5b-Inversion, ROS1-fusion and mutations and polymorphisms of TP53. Conclusions: CTNNB1 mutations occur alone or in combination with other known oncogenic aberrations in NSCLC. Results of the ongoing clinical characterization of the patients as well as the prognostic and predictive impact of CTNNB1 mutations will be presented.
Information Resource on Animal Models and Genetic Stocks
Journal: JNCI Journal of the National Cancer Institute (1970)

Journal Article Information Resource on Animal Models and Genetic Stocks Get access JNCI: Journal of the National Cancer Institute, Volume 44, Issue 2, February 1970, Page 485, https://doi.org/10.1093/jnci/44.2.485 Published: 01 February 1970
Hormone Intoxication May Follow Adrenalectomy
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bendamustine-Bortezomib-Desametasone (BVD) in the Management of Relapsed and Refractory Multiple Myeloma : A REAL-Life Experience
Authors: Claudio Cerchione, Lucio Catalano, Anna Emanuele Pareto, Santina Basile, Luana Marano, Ilaria Peluso, Luigia Simeone, Orsola Vitagliano, Davide Nappi, Salvatore Palmieri, Stefano Rocco, Felicetto Ferrara, Fabrizio Pane
Journal: Blood (2016)
APC-activated long noncoding RNA inhibits colorectal carcinoma pathogenesis through reduction of exosome production
Authors: Feng-Wei Wang, Chen-Hui Cao, Kai Han, Yong-Xiang Zhao, Mu-Yan Cai, Zhi-Cheng Xiang, Jia-Xing Zhang, Jie-Wei Chen, Li-Ping Zhong, Yong Huang, Su-Fang Zhou, Xiao-Han Jin, Xin-Yuan Guan, Rui-Hua Xu, Dan Xie
Journal: Journal of Clinical Investigation (2021)

Following the publication of this article, the authors noted that the images presented for Figure 11D (shRNA-3 lncRNA-APC1 group) were identical to the images for Figure 7D (shRNA-3 lncRNA-APC1 exo group, capillary tube formation assay) and Supplemental Figure 8D (si-1 APC group, transwell assay), respectively.The authors have provided the correct version of Figure 11D based on the original data, and the point values in the graphs have been updated accordingly.That version is below.
Graduate Education in Public Health
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Impact of Polycyclic Aromatic Hydrocarbons and Fine Particles on Pregnancy Outcome
Authors: Jan Dejmek, Ivo Solansky, Ivan Benes, Jan Lenicek, Radim J. Sram
Journal: Environmental Health Perspectives (2000)

The relationship between intrauterine growth retardation (IUGR) and exposure to particulate matter [less than/equal to] 10 microm (PM(10)) and particulate matter [less than and equal to] 2.5 microm (PM(2.5))( )in early pregnancy was recently studied in the highly polluted district of Teplice (Northern Bohemia). From this observation rose the question about the possible role of the carcinogenic fraction of polycyclic aromatic hydrocarbons (c-PAHs), which are usually bound to fine particles. The impact of c-PAHs and fine particles on IUGR was analyzed in Teplice and in Prachatice, a region with similarly high c-PAH but low particle levels. All European, single live births occurring in a 4-year period in Teplice (n = 3,378) and Prachatice (n = 1,505) were included. Detailed personal data were obtained via questionnaires and medical records. Mean PM(10), PM(2.5,) and c-PAHs levels during the 9 gestational months (GM) were estimated for each mother. Adjusted odds ratios (AORs) of IUGR for three levels of c-PAHs (low, medium, and high) and for continuous data were estimated after adjustment for a range of covariates using logistic regression models. In the present 4-year sample from Teplice, previously published results about increasing IUGR risk after exposure to particles in the first GM were fully confirmed, but no such effects were found in Prachatice. The AOR of IUGR for fetuses from Teplice exposed to medium levels of c-PAHs in the first GM was 1.60 [confidence interval (CI), 1.06-2. 15], and to high levels 2.15 (CI, 27-3.63). An exposure-response relationship was established by analyzing the continuous data. For each 10 ng increase of c-PAHs in the first GM, the AOR was 1.22 (CI, 1.07-1.39). About the same relationship was observed in Prachatice in spite of the low particle levels. The results prove that exposure to c-PAHs in early gestation may influence fetal growth. The particulate matter-IUGR association observed earlier may be at least partly explained by the presence of c-PAHs on particle surfaces.
Gamma Hydroxy Butyrate Use— New York and Texas, 1995-1996
Journal: JAMA (1997)

Gamma hydroxy butyrate (GHB) is a central nervous system depressant approved as an anaesthetic in some countries; however, with the exception of investigational research, it is not approved for any use in the United States. Primary groups using GHB include party and nightclub attendees and bodybuilders. In addition, GHB is one of several agents characterized as a "date rape" drug. During August 1995-September 1996, poison control centers in New York and Texas received reports of 69 acute poisonings and one death attributed to ingestion of GHB. This report describes two cases and summarizes the investigations of GHB use in Texas and New York. The findings of these investigations underscore the health hazards associated with use of GHB.
Percutaneous transluminal coronary angioplasty in New York State. Risk factors and outcomes
Authors: E. L. Hannan
Journal: JAMA (1992)

<h3>Objective.</h3> —To identify significant independent risk factors for major percutaneous transluminal coronary angioplasty outcomes. <h3>Design.</h3> —Retrospective analysis using univariate and logistic regression analysis to identify significant independent risk factors for adverse outcomes. <h3>Setting.</h3> —All 31 hospitals performing percutaneous transluminal coronary angioplasty in New York State in 1991. <h3>Patients.</h3> —All 5827 patients undergoing percutaneous transluminal coronary angioplasty between January 1, 1991, and June 30, 1991, in New York State. <h3>Main Outcome Measures.</h3> —In-hospital mortality, major complication(s) (in-hospital mortality, myocardial infarction, and/or emergency coronary artery bypass graft), and absence of angiographic success (stenosis reduction of less than 20% on any attempted lesion or residual stenosis of at least 50% on any attempted lesion). <h3>Main Results.</h3> —Before discharge from the hospital, a total of 37 patients (0.63%) died; 67 patients (1.1%) suffered a myocardial infarction, with a mortality rate of 4.5%; and 97 patients (1.7%) underwent emergency coronary artery bypass graft surgery, with a mortality rate of 2.1% (no deaths in 85 patients who were hemodynamically stable and two deaths among 12 patients who were hemodynamically unstable). A total of 187 patients (3.2%) experienced a major complication. Angiographic success was achieved for 88% of all patients. Multivariate analysis found four independent preprocedural variables related to death: female gender, hemodynamic instability, shock, and ejection fraction. <h3>Conclusions.</h3> —Percutaneous transluminal coronary angioplasty outcomes in New York compare favorably with other recent results reported in the literature. Several preprocedural variables markedly increase the incidence of adverse events. (<i>JAMA</i>. 1992;268:3092-3097)
The trend of federal and private support of research as applied to anesthesiology
Authors: H. T. Benzon
Journal: JAMA (1982)

The trend of federal and private support of research as applied to anesthesiology increased from 1940 to 1975 and declined after 1975. Articles published in the<i>journal Anesthesiology</i>were supported primarily by private organizations in 1940 to 1955, funded equally by federal and private organizations in 1956 to 1960, and funded mostly by governmental agencies since 1961. (<i>JAMA</i>1982;247:1166-1167)
Targeted Screening for Childhood Lead Exposure in a Low Prevalence Area—Salt Lake County, Utah, 1995-1996
Journal: JAMA (1997)

During 1991-1994, an estimated 930,000 U.S. children aged < 6 years had blood lead levels (BLLs) > or = 10 micrograms/dL, and the risk for an elevated BLL was greatest among children who were non-Hispanic black or Mexican American, from low-income families, living in large metropolitan areas, or living in housing built before 1946. Because risk for lead exposure is associated with several different factors, it can vary greatly across relatively small areas. To establish the local prevalence and distribution of childhood lead exposure and develop local blood lead screening recommendations, the Salt Lake City-County Health Department (SLCCHD) offered free blood lead screening to all children aged 12-36 months enrolled at the seven Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) clinics in Salt Lake County, Utah (1995 population: 812,000), during January-October 1995. This report presents findings of the screenings at WIC clinics, describes the design and promotion of local targeted screening recommendations, and describes the resulting increases in appropriate BLL screenings among children.
Cholera
Authors: N. Jungalwalla
Journal: BMJ (1948)

<h3>Abstract</h3> The coronavirus disease 2019 (COVID-19) pandemic poses particular challenges for migrant workers around the world. This study explores the unique experiences of foreign domestic workers (FDWs) in Hong Kong, and how COVID-19 impacted their health and economic wellbeing. Interviews with FDWs (<i>n</i> = 15) and key informants (<i>n</i> = 3) were conducted between May and August 2020. FDWs reported a dual-country experience of the pandemic, where they expressed concerns about local transmission risks as well as worries about their family members in their home country. Changes to their current work situation included how their employers treated them, as well as their employment status. FDWs also cited blind spots in the Hong Kong policy response that also affected their experience of the pandemic, including a lack of support from the Hong Kong government. Additional support is needed to mitigate the particularly negative effects of the pandemic on FDWs.
Adverse Reactions to Tetanus Toxoid
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Parsons' papilloedema, 70 years on.
Journal: BMJ (1978)

Should the disease be progressive and disabling, treatment should aim at controlling the arthritis rather than simply relieving symptoms.For reasons not yet understood drugs which may help in seropositive rheumatoid arthritis seem to be of no help to patients who carry the HLA B27 antigen.Neither gold2 nor penicillamine are of proved value in psoriatic arthritis, though some rheumatologists have reported that gold may be helpful3 and does not exacerbate the skin lesions.Allopurinol has been given on the basis that hyperuricaemia may accompany psoriasis.Long term, however, control of the disease is best achieved with antimitotic agents.Methotrexate, a folate antagonist, has been most widely used.For example, Kersley4 treated ten patients with psoriatic arthritis with oral methotrexate; skin lesions improved in eight of them and the joint symptoms improved in five.Ulceration of the mouth was common, but no blood dyscrasias occurred.Three patients with psoriatic arthritis all responded to intravenous methotrexate.5Side effects are common with methotrexate, occurring in up to one-third of all patients.6These may be serious and sometimes fatal.Liver damage is more common when the drug is given on a continuous low-dosage regimen than when given intermittently.7 Acute gout may complicate the intravenous use of methotrexate,8 while gastrointestinal side effects include diarrhoea, haemorrhage, and perforation.Regular blood checks are mandatory for the early detection of bone-marrow depression.Baum et a19 treated 13 patients with psoriasis and arthritis with 6-mercaptopurine in daily doses ranging from 20 mg to 150 mg.Eleven of them showed improvement in three weeks or less, with minimal side effects.After treatment was stopped the remissions lasted for up to 10 months.Azathioprine has also been tried:10 the response of the arthritis was excellent or good in nine out of 10 patients, with concomitant but also fluctuating improvement of the skin lesions.In two patients treatment was stopped because of gut disturbances and in one because of mild thrombocytopenia.In general, antimitotic agents should be reserved for refractory and fulminating cases which do not respond to conventional, less toxic drugs.We need controlled studies of drugs said to act long term, and though these are difficult to arrange they should not prove impossible.
"ON SELECTION OF MEDICAL READING"
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pseudoseizures
Authors: Carla Hellekson
Journal: JAMA (1983)

<i>Pseudoseizures</i>presents contributions from 15 authors in an attractive 231-page volume. Topics are divided into three major sections covering "Medical and Neurological Aspects"; "EEG, Intensive Monitoring, and Videotape"; and "Psychiatric Aspects." While pseudoseizures or hysterical epilepsy receives major attention, excellent chapters deal with conditions such as syncope, hyperventilation, and narcolepsy. Particularly valuable are the chapters dealing with the controversial subjects of aggression and epilepsy, and the "Legal Aspects of Pseudoseizures." In view of the broad spectrum of issues discussed, Gower's phrase "borderlands of epilepsy" (p 31) may be a more apt title for this book. The contributors, primarily psychiatrists and neurologists from Great Britain, Canada, and the United States, vary in perspective. Style and content are somewhat uneven. Tables are used effectively to illustrate points concerning differential diagnosis in the chapter on narcolepsy. Discussion of "Management of Hysterical Seizures" shares valuable experience with this challenging patient population and emphasizes the
The Year of the Kidney
Authors: E. J. H.
Journal: Annals of Internal Medicine (1969)

The Literature of Medicine1 March 1969The Year of the KidneyE. J. H.E. J. H.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-70-3-656 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Excerpt"Perhaps never before have so many important textbooks and monographs—first issues and new editions—about the kidney and its diseases been published in the space of 12 months as in 1968. The most notable of the monographs was Jean Oliver'sNephrons and Kidneys, reviewed in the September 1968 ANNALS. This major contribution in developmental and comparative morphology of the mammalian kidney is likely to join Cushny'sThe Secretion of the Urine, A. N. Richard's papers on the micropuncture studies of glomerular and tubular function, Homer Smith'sThe Kidney, and Dr. Oliver's previous books as a classic in the literature of nephrology.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1969Volume 70, Issue 3Page: 656-658KeywordsKidneysNephrologyNephronsRenal diseasesUrine ePublished: 1 December 2008 Issue Published: 1 March 1969 PDF downloadLoading ...
Delirium in a coronary care unit
Authors: D. L. Parker
Journal: JAMA (1967)

Eleven patients experienced varying degrees of delirium during the treatment of myocardial infarction in a coronary care unit. Sensory monotony and sleep deprivation seem to be of importance in relation to this state. This potentially serious complication may be combated by placement of the patient in a reassuring and less monotonous environment, and by the judicious use of phenothiazine drugs for sedation.