tbuckley/cabot-search huggingface dataset:
MBRS-72. MiR-212 FUNCTIONS AS A TUMOR SUPPRESSOR GENE IN GROUP 3 MEDULLOBLASTOMA VIA TARGETING NUCLEAR FACTOR I/B (NFIB)
Authors: Naveenkumar Perumal, Ranjana Kanchan, Pranita Atri, Ramakanth Venkata, Ishwor Thapa, Mohd Nasser, Surinder Batra, Sidharth Mahapatra
Journal: Neuro-Oncology (2020)

Abstract Medulloblastoma (MB), the most frequent malignant pediatric brain tumor is divided into four primary subgroups, i.e. wingless-type (WNT), sonic hedgehog (SHH), group 3, and group 4. Haploinsufficiency of chromosome 17p13.3 and c-myc amplification distinguish high-risk group 3 tumors and are associated with rapid recurrence and early mortality. We sought to identify the role of miR-212, which resides on chromosome 17p13.3, in the pathophysiology of group 3 medulloblastoma. RNA expression analyses revealed dramatically reduced levels of miR-212 in group 3 tumors and cell lines mainly through epigenetic silencing via histone modification (deacetylation). Restoring in vitro expression reduced tumor cell proliferation with decreased p-AKT and p-ERK levels, colony formation, migration and invasion in group 3 MB. Interestingly, a shift in differential c-myc phosphorylation (from serine-62 to threonine-58) was noted, resulting in reduced total c-myc levels, concurrent with elevated cellular apoptosis. In turn, pro-apoptotic binding partners of c-myc, i.e. Bin-1 and P19ARF, were upregulated in these cells. A dual luciferase assay confirmed direct targeting of miR-212 to NFIB, a nuclear transcription factor implicated in metastasis and recurrence. Concurrently, increased expression of NFIB was confirmed in group 3 MB tumors with poor survival in high NFIB-expressing patients. Transient NFIB silencing in vitro reduced tumor cell proliferation, migration and invasion, and medullosphere formation along with a reduction in stem cell markers (Nanog, Oct4, Sox2, CD133) and the multi-drug resistance maker, ABCG2. Taken together, these results substantiate the tumor suppressive role of miR-212 in group 3 medulloblastomas and provide a potential new therapeutic target, NFIB.
Physicians Find Teleactivity Hot Near the North Pole
Authors: M. Mitka
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tuberculosis Genotyping—United States, 2004-2010
Journal: JAMA (2012)

Tuberculosis (TB) genotyping is a laboratory-based genetic analysis of the bacteria that cause TB disease (i.e., any of the organisms in the Mycobacterium tuberculosis complex). When combined with epidemiologic data, TB genotyping has sufficient discriminatory power to help find TB cases likely to be in the same chain of transmission or determine that cases are not related. Since 2004, >70,000 M. tuberculosis isolates have been genotyped through partnerships between CDC, national genotyping laboratories, and state and local public health departments, with a goal to genotype at least one M. tuberculosis isolate for each case of culture-positive TB in the United States. National genotype surveillance coverage, or the proportion of culture-positive TB cases with a genotyped isolate, increased from 51.2% in 2004 to 88.2% in 2010. The TB Genotyping Information Management System (TB GIMS), accessible to public health departments through a secure, online web portal, was launched in 2010. TB GIMS enables systematic collection of genotyping results, which have been available since 2004, and integrates those results with epidemiologic, geographic, demographic, and clinical data collected by the National TB Surveillance System (NTSS) since 1993. Genotyping timeliness, represented by the median time from specimen collection until linked genotyping results and surveillance data are available to TB GIMS users, improved from 22 weeks in July 2010 to 11 weeks in December 2010. These improvements in genotype surveillance coverage and timeliness will improve outbreak detection efforts and enable more in-depth studies of TB epidemiology, leading to better use of limited public health resources.
Vertebral coccidioidomycosis presenting as Pott's disease
Authors: L. J. Wesselius
Journal: JAMA (1977)

HUMAN disease induced by the fungus<i>Coccidioides immitis</i>is endemic to the southwestern United States. In the vast majority of persons affected, coccidioidomycosis affects only the respiratory tree. We report a case in which the condition presented as vertebral osteomyelitis resembles tuberculous spondylitis (Pott's disease). We wish to emphasize the similarities between these two entities and the importance of recognizing coccidioidomycosis in the differential diagnosis of Pott's disease. <h3>Report of a Case</h3> An 82-year-old man entered the Tucson Veterans Administration Hospital on November 15, 1976, with a four-month history of midthoracic back pain. He had first noted this discomfort following heavy exertion and lifting. During the two months prior to hospital admission there had been a 13-pound weight loss. He denied having cough, sputum production, fever, chills, or night sweats. The patient did recall a flu-like illness in January 1976, and in February 1976 a chest film had shown a
JAMA Internal Medicine
Authors: Phil Fontanarosa, Annette Flanagin, Brenda Gregoline, Lauren Fischer, John Mcfadden, Karen Boyd, Rochelle Lodder, Sam Wilder, Diane Cannon, Connie Manno, Fred Marshall, Catherine Copyreaders, Stephanie Alden, Jan Beckmeyer, Mary Clavey, Paula Coerver-Connolly, Laura Glitman, Kenneth King, Donna Lane, Caroline Thordsen, Wanda Assistant, Larry Bryant, Monica Mungle, Elaine Williams, Kathryn Brokke, Lenette Gardner-Gullens, Fanny Brown, Paul Frank, Peter Kim, Rachell Lozano, Michaela Mark, Elizabeth Scientifi, Michael Berkwits, Michelle Kurzynski, Eric Butkus, Will English, Mustafa Ishag, Reuben Rios, Ronna Henry, Joshua Bird, Karen Bucher, Samantha Welker, David Song, Deputy Livingston, Thomas Cole, Marla Hall, Deanna Willis, Yolanda Davis, Joseph Thornton, Preeti Malani, Deanna Bellandi, Jim Periodical, Thomas Easley, Brian Shields, Monica Smith, Jeff Ery, J Bonistalli, Kathy Russell, Mirna Monal, Stacey Mchugh, Tim Melroy, Marketing Thornbury, Tricia Castellano Classifi, Thalia Moss, Mike Harvey, Susan Henning, Saskia Bolore, Gretchen Linder, Brian Mccartney, David Baum, Rebecca Haas, Christine Hearne, Natasha Nekola, Ron Marketing, Paul Gee, Matt Herron, Elizabeth Solaro, Geoff Rey, Rick Bell, Lindsay Dawson, Craig Mccaff Rey, Michael Mcgraw, Romando Rossini, Stacy Staff, Millette Jackson-Bates, Karen Adams-Taylor, Karl Elvin, Jaye Mize, Sean O'donnell, Sue Managers, David Antos, Chris Borden, Debbie Camp, Lydia Cruz, Scott Curl, Diane Darnell, Colleen Kelly, Chris Meyer, Annemarie Neff, J Neff, Sean Ohlson, Phil O'leary, Bill Pedone, Susan Price, Denise Steinhauser, Joe Advertising, Production Services, Kim Boler, Rhonda Brown, Timothy Burke, Daniel Degroot, Jordynn Farrar, Euwanaha Joiner-Smith, Cindy Rendlen, Ellen Yoshihara, Circulation Services, Julie Burton, Dexter Golden, Erin Hinchcliff, Noemi Rivera, Geneine Van, Someren Composition, New Media, Gail Barrett, Regina Brownlee, Amanda Camino, Brenda Chandler-Grayer, Emily Dunn, Amy Evers, Teri Hutchison, Mary Kuranda, Joshua Lampinen, Nathan Mitre, Patricia Panek, La Son, Diggs Sledge, George Thomson Graphics, Joe Amft, Maria Duda, Fred Furtner, Carolyn Hall, Maria Kowalkowski, Proofreading Carol, Joy Farrell, Daniel James, Judith Literskis, Teresa Omiotek, James Madara, Bernard Hengesbaugh, Zachary Goldberger, Nora Goldschlager, San Francisco, Gregory Marcus, Elsayed Soliman, Carolina Cme, Jeff Rey Tabas, Fiona Clement, Rebecca Larson, Deborah Grady, Howard Bauchner, Rita Redberg, Rosemary Gibson, Shannon Brownlee, Tanner Caverly, Ann Arbor, Brandon Combs, Christopher Moriates, Neel Shah, Robert Steinbrook, New Haven, James Colbert, David Brown, St Louis, Lara Goitein, Santa Fe, New Mexico, Chi-Yuan Hsu, Grace Lin, Mary Mcdermott, C Noel, Bairey Merz, Los Angeles, Samia California, Judith Mora, Kathryn Prochaska, Mary Rexrode, New Tinetti, Nicolas Rodondi, Iona Heath, Mitchell Katz, Patrick California, John Boscardin, John Neuhaus, Kenneth Covinsky, Joseph Ross, Blake Charlton, Rachel Stern, Charlotte Dudley, Kate Denevan
Journal: JAMA Internal Medicine (2015)
Psychiatry
Authors: D. X. Freedman
Journal: JAMA (1978)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Report of the AMA Education and Research Foundation
Journal: JAMA (1962)

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Error in Abstract, Figure 3, and in Captions to Figures 1, 2, and 4
Authors: Kenneth Feder, Kira Riehm, Ramin Mojtabai
Journal: JAMA Psychiatry (2020)

Amir Sariaslan, PhD; Louise Arseneault, PhD; Henrik Larsson, PhD; Paul Lichtenstein, PhD; Seena Fazel, MD
The bone morphogenetic protein axis is a positive regulator of skeletal muscle mass
Authors: Catherine E. Winbanks, Justin L. Chen, Hongwei Qian, Yingying Liu, Bianca C. Bernardo, Claudia Beyer, Kevin I. Watt, Rachel E. Thomson, Timothy Connor, Bradley J. Turner, Julie R. McMullen, Lars Larsson, Craig A. Harrison, Paul Gregorevic
Journal: The Journal of Experimental Medicine (2013)
POLYMER-FUME FEVER
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Another Turn for Lafayette
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lymphocytic thyroiditis possibly induced by diphenylhydantoin
Authors: J. J. Kuiper
Journal: JAMA (1969)

Two entities of presumed immunologic etiology, diffuse lymphocytic thyroiditis and a generalized serum sicknesslike illness, were observed simultaneously in a 19-year-old patient receiving diphenylhydantoin sodium (Dilantin). Diphenylhydantoin may well have induced both hypersensitivity phenomena in this patient.
Cancer in southeast Asia. Strategies for control
Authors: A. I. Sutnick
Journal: JAMA (1984)

The incidence and mortality from cancer has been increasing steadily in southeast Asia, probably related to increased life expectancy resulting from control of some of the major diseases. There are many impediments to cancer control in that part of the world, including poverty, limited access to health services, primarily rural distribution of population, and the dependence on treatment by traditional healers. There are potentially controllable environmental factors associated with some cancers commonly seen in countries of southeast Asia. We have proposed changes in the approach to cancer control in these countries. These include political organization, professional education programs, manpower development in special areas of need, public education in cancer prevention, early detection, team approaches to diagnosis and treatment, and emphasis on epidemiology in research. (<i>JAMA</i>1984;251:495-497)
Federal and State Aid
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Rationing Resources While Improving Quality
Authors: Barry L. Fisher
Journal: JAMA (1995)

<h3>To the Editor.</h3> —In the September 14, 1994, issue of<i>JAMA</i>, Dr Eddy<sup>1</sup>uses three examples of increasing efficiency of utilizing limited health care resources. However, his first two examples, restricting mammography to more appropriate ages and changing the indications for cholesterol-reducing drug therapy, differ significantly from his third example, the use of high (HOCA) or low (LOCA) osmolar contrast agents balanced against the use of cervical cancer screening. In the first two examples, Eddy cites published scientific data to support a constructive and efficient reduction of overutilization of a single resource (mammography in the first case and cholesterol-reducing drugs in the second case), resulting in improvement in the quality of care, each for one specific illness. In his third example, however, the only resource common to both interventions is money; two unrelated illnesses are being balanced. He advocates administering HOCAs to all patients, even to those demonstrated to
A Text Book of Physiology.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AMA Specialty Journal Abstracts
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hypoglycemia Unawareness
Authors: JOHN E. GERICH, MARIAN MOKAN, THIEMO VENEMAN, MARY KORYTKOWSKI, ASIMINA MITRAKOU
Journal: Endocrine Reviews (1991)

ADECREASE in the plasma glucose concentration normally evokes a characteristic hierarchy of responses to avoid development of hypoglycemia (1–3) (Fig.1). Initially at approximately 70 mg/dl (4 mm), there is an increase in the secretion of counterregulatory hormones [glucagon, epinephrine, GH, and cortisol (ACTH)] and a concommitant increase in the discharge of autonomic nervous system neurotransmitters (norepinephrine and acetylcholine). If these initial responses do not prevent a further decrease in the plasma glucose concentration, by the time the plasma glucose concentration reaches 60 mg/dl (3.4 mm), the magnitude of the released catecholamines and acetylcholine is such that autonomic symptoms (sweating, tremor, hunger, anxiety, and palpitations) occur (2, 3). These symptoms can mainly but not exclusively be attributed to neuronally released transmitters rather than adrenomedullary catecholamines, because most symptoms are absent or markedly attenuated by ganglionic blockade, cervical cord section, and sympathectomy but not by adrenalectomy (4–10). In an individual who has previously experienced such symptoms, they usually act as a warning to undertake protective measures against impending hypoglycemia (e.g. intake of food). This activation of the autonomic nervous system has probably evolved primarily as an alarm, rather than a counterregulatory mechanism, because neither ganglionic blockade, sympathectomy, adrenergic antagonists, nor cervical cord section by themselves lead to greater hypoglycemia after insulin administration and do not attenuate restoration of euglycemia (4–11). However, the autonomic, specifically the adrenomedullary, response becomes important to prevention or correction of hypoglycemia when other counterregulatory factors (especially glucagon) are deficient as is the case in most patients with insulin-dependent diabetes mellitus (IDDM) (12).