tbuckley/cabot-search huggingface dataset:
Anisodamine inhibits thromboxane synthesis, granulocyte aggregation, and platelet aggregation. A possible mechanism for its efficacy in bacteremic shock
Authors: R. J. Xiu
Journal: JAMA (1982)

Anisodamine hydrochloride is a vasoactive drug produced in the People's Republic of China that appears efficacious in clinical and experimental bacteremic shock, and about whose mode of action little is known. Suspecting that the drug might work by inhibition of platelet or granulocyte aggregation, or both, we tested it in these systems. Anisodamine proved a modest inhibitor of granulocyte aggregation and a powerful inhibitor of platelet aggregation; thromboxane synthesis was inhibited in anisodaminetreated platelets, further suggesting that the biochemical mode of action might be inhibition of cyclo-oxygenase or thromboxane synthetase. (<i>JAMA</i>1982;247:1458-1460)
ANOTHER FAITH DELUSION.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Comparison of acetylmethadol and methadone in the treatment of long-term heroin users. A pilot study
Authors: J. H. Jaffe
Journal: JAMA (1970)

In a double-blind controlled study, d1-α-acetylmethadol hydrochloride a synthetic congener of methadone hydrochloride with a 72- to 96-hour duration of action was compared to methadone in the treatment of long-term compulsive heroin users. The subjects were ambulatory patients whose conditions were already stabilized with oral administration of methadone. Over a five-week period of observation there were no differences in social adjustment between those patients whose conditions were maintained with a daily methadone regimen and those given d1-α-acetylmethadol three times a week.
Gemcitabine, oxaliplatin and weekly high-dose 5-FU as a 24-hr-infusion in chemonaive patients with advanced or metastatic pancreatic adenocarcinoma: preliminary results of a multicenter phase II-study
Authors: A. D. Wagner, P. Buechner-Steudel, A. Wein, R. Masri-Zada, H. Schmalenberg, G. Kleber, O. Kuss, M. Moehler, R. Behrens, W. E. Fleig
Journal: Journal of Clinical Oncology (2004)

4096 Background: Combinations of gemcitabine (GEM)/5-FU, GEM/oxaliplatin (LOHP) or 5-FU/LOHP work synergistically in pancreatic and/or colorectal malignancies, and have non-overlapping safety profiles. This phase II-study was designed to evaluate the efficacy and safety of the triple combination GEM/LOHP/5-FU in patients (pts) with advanced pancreatic adenocarcinoma. Methods: Eligibility criteria: chemonaive pts with histologically proven advanced, recurrent or metastatic pancreatic adenocarcinoma (ECOG 0–1: expected survival >3 months: measurable disease: adequate renal, hepatic and bone marrow function). According to the results of our phase I-study (Proc ASCO 2003, p 1298),pts were treated with GEM 900mg/m2 as a 30-min infusion, followed by LOHP (2-hr infusion) after a 30 min rest and 5-FU (24-hr-infusion) on d 1, 8, then every 3 weeks. The primary endpoint was tumor response, secondary endpoints were survival, time to progression, toxicity, clinical benefit and quality of life. Results: 45 pts enrolled, median follow up is 5.6 months. Pt. characteristics: m/f 31/14, median age 63 (range 45–74), ECOG 0/1 20/25, locally advanced/metastatic disease 18/27 pts. (40/60%). Median survival of all pts is 7.4 months (95% CI: 4.3–9.9). Currently 169 cycles in 32 pts. can be evaluated for toxicity: grade III/ IV (NCI-CTC) toxicities occurred in 23.4/ 3% of cycles and were leucopenia 1.8/ 0%, thrombocytopenia 3/ 0%, anemia 2.4/ 0 %, nausea 3.6/ 0%, emesis 0.6/ 0%, anorexia 3/ 1.8%, fatigue 1.2/ 0.6%, elevated bilirubin 2.4/ 0.6% or AP 2.4/ 0%, thrombosis/embolism 1.2/ 0 %, somnolence 0.6/ 0%, hypoglycemia 0.6/ 0%. Analysis of response is still pending. Conclusions: The GEM/LOHP/5-FU combination is tolerated well. The current survival is promising, but has to be confirmed in a phase III study. (Supported by grants from Eli Lilly and Company, Indianapolis, IN, USA and Sanofi-Synthelabo, Paris, France) No significant financial relationships to disclose.
SOCIETY PROCEEDINGS.
Journal: JAMA (1889)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Triplet repeat mutations: amplification within pedigrees generates three human diseases
Authors: T. Randall
Journal: JAMA (1993)

AN UNSTABLE DNA sequence, made up of three contiguously repeating nucleotides, has been pinpointed recently as the genetic cause of fragile X syndrome, myotonic dystrophy, and Kennedy disease. This novel mutation provides a specific molecular mechanism behind the phenomenon of anticipation— the clinical observation that some genetic diseases manifest at either an earlier age or more severely in successive generations. (Please refer to accompanying article.) The consequences of this unstable sequence vary widely, depending on the gene in which it occurs and its location within the gene. So too does the number of repeats that lead to normal, mildly, and severely affected outcomes. The following summarizes more than a dozen presentations on this topic at the recent annual meeting of the American Society of Human Genetics. <h3>Kennedy Disease</h3> In early 1991, researchers identified an expansion of the CAG trinucleotide repeat sequence in the androgen receptor gene of patients with X-linked
index to advertisers
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Heart
Authors: Neil S. Skolnik
Journal: Annals of Internal Medicine (1989)

Ad Libitum15 January 1989The HeartNeil S. Skolnik, MDNeil S. Skolnik, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-110-2-173_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIs, I'm sure, acomedian, becausewhat matters, morethananythingelse,is timing.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 January 1989Volume 110, Issue 2Page: 173-173KeywordsHeart Issue Published: 15 January 1989 Copyright & Permissions©1989 American College of PhysiciansPDF downloadLoading ...
Heart's response to stress may predict subsequent hypertension in black children
Authors: C. A. Raymond
Journal: JAMA (1988)

BLACK AMERICANS are one third again as likely as whites to have hypertension, say 1988 statistics compiled by the American Heart Association. Now, according to results of a Tennessee study presented at the annual meeting of the Society of Behavioral Medicine, there are indications that black children's cardiovascular systems are more likely to exhibit an enhanced reactivity to stress—a phenomenon that several studies have linked to the subsequent development of hypertension (<i>JAMA</i>1986;256:11-17). It is not yet certain whether this reactivity is simply a marker of some other factor that predisposes to hypertension or is directly involved in its cause. Furthermore, studies involving measures of cardiovascular reactivity have used widely varying methods to assess the phenomenon, from cold pressor tests to backward-writing tasks. In the cold pressor test, the subject immerses the right hand and forearm into ice water for one minute. The latter test theoretically induces stress by forcing
An outbreak of congenital rubella in Chicago
Authors: C. Lamprecht
Journal: JAMA (1982)

After an outbreak of rubella in Chicago in 1978, an intensive survey of local health care personnel and hospital records identified 31 infants with congenital rubella syndrome (CRS). Rubella virus was isolated from 11 infants; rubella-IgM antibodies were demonstrated in seven infants; ten babies had persistent high rubella hemagglutination-inhibition (HI) titers. The incidence of CRS in Chicago between July 1978 and June 1979 was 48.9 per 100,000 live births. Mothers of babies with CRS frequently remembered a rash-illness during pregnancy (56%), were unmarried (74%), and were primigravidas (64%). No mother had received rubella vaccine. Review of prenatal rubella HI testing and follow-up immunization in one hospital showed that only eight (10.8%) of 74 seronegative women received rubella vaccine after delivery. This outbreak of CRS, a preventable disease, indicates that physicians need to place increased emphasis on detection and vaccination of susceptible adult women. (<i>JAMA</i>1982;247:1129-1133)
Indications of Physical Overexertion
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Skin pigmentation and chlorpromazine
Authors: A. S. Zelickson
Journal: JAMA (1965)

SINCE THE first reports detailing a new syndrome of dermatologic and ophthalmologic changes in patients receiving prolonged and high doses of chlorpromazine,<sup>1,2</sup>there have been many subsequent papers dealing with the subject.<sup>3-10</sup>Many of the reports have been concerned with the development of slate-blue skin pigmentation in these patients, and the general consensus has been that it is the result of a melanin or melaninlike substance. As previously reported, this syndrome is characterized by discoloration of the exposed areas of the body. The pigmentation may range in degree from a slight darkening of the skin to a definite slate-gray or blue color. Histologic examination has revealed a pigment chiefly in the corium, which has been suggested to be melanin. Ocular changes have been noted with and without overt skin pigmentation. The eye changes consist of a deposition of fine particles in the anterior capsular and subcapsular portion of
Drug Industry Situation Uncertain But Hopeful
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mycobacterium avium-intracellulare: another scourge for individuals with the acquired immunodeficiency syndrome
Authors: H. Masur
Journal: JAMA (1982)

The<i>Mycobacterium avium-intracellulare</i>complex (MAC) is a commonly encountered group of environmental contaminants that are recognized to cause localized lung disease, particularly in persons in the southeastern United States who have preexisting lung disease. The rarity of human MAC disease has indicated that these organisms are relatively avirulent, yet it is hardly surprising that a few immunosuppressed adults (about 14) and children (about 18) have been described during the years to have had disseminated MAC disease. In this issue, Zakowski and colleagues (p 2980) verified the occurrence of disseminated disease in five homosexual males with acquired immunodeficiency (AID) syndrome, all recognized within a nine-month period at one institution. This sudden occurrence of five cases in conjunction with similar observations from several other institutions raises intriguing questions about the epidemiology and pathogenicity of MAC.<sup>1</sup> The MAC is present in dust, dirt, fresh water, ocean water, and animal feed.<sup>2</sup>These
Intracardiac Phonocardiography
Authors: M IRIARTE EZCURDIA, L GARATE BERASALUCE
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Calcifying Fibrous Pseudotumor
Authors: JABOUR KHOURY, JACQUELINE JERUSHALMI, ELIAS NASER, JACOB VARKEL, NORMAN LOBERANT, HECTOR ISAAC COHEN
Journal: Clinical Nuclear Medicine (2002)

KHOURY, JABOUR M.D.*; JERUSHALMI, JACQUELINE M.D.*; NASER, ELIAS M.D.†; VARKEL, JACOB M.D.†; LOBERANT, NORMAN M.D.‡; ISAAC COHEN, HECTOR M.D.§ Author Information
Inositol Phosphate Formation and Its Relationship to Calcium Signaling
Authors: Arlene R. Hughes, James W. Putney
Journal: Environmental Health Perspectives (1990)

The activation of a variety of cell surface receptors results in a biphasic increase in the cytoplasmic Ca2+ concentration due to the release or mobilization of Ca2+ from intracellular stores and to the entry of Ca2+ from the extracellular space. It is well established that phosphatidylinositol 4,5-bisphosphate hydrolysis is responsible for the changes in Ca2+ homeostasis. Stimulation of Ca2(+)-mobilizing receptors also results in the phospholipase C-catalyzed hydrolysis of the minor plasma membrane phospholipid, phosphatidylinositol 4,5-bisphosphate, with the concomitant formation of inositol (1,4,5) trisphosphate [1,4,5)IP3) and diacylglycerol. Analogous to the adenylyl cyclase signaling system, receptor-mediated stimulation of phospholipase C also appears to be mediated by one or more intermediary guanine nucleotide-dependent regulatory proteins. There is strong evidence that (1,4,5)IP3 stimulates Ca2+ release from intracellular stores. The Ca2(+)-releasing actions of (1,4,5)IP3 are terminated by its metabolism through two distinct pathways. (1,4,5)IP3 is dephosphorylated by a 5-phosphatase to inositol (1,4) bisphosphate; alternatively, (1,4,5)IP3 can be phosphorylated to inositol (1,3,4,5) tetrakisphosphate by a 3-kinase. Whereas the mechanism of Ca2+ mobilization is understood, the precise mechanisms involved in Ca2+ entry are not known. A recent proposal that (1,4,5)IP3 secondarily elicits Ca2+ entry by emptying an intracellular Ca2+ pool will be considered. This review summarizes our current understanding of the mechanisms by which inositol phosphates regulate cytoplasmic Ca2+ concentrations.
VACCINATION.
Authors: JOHN H. RAUCH
Journal: JAMA (1894)

Owing to the increase of smallpox in the United States during the last two months, the State Boards of Health of Ohio, Iowa and Wisconsin have ordered vaccination of all the school children, and in some cases of the entire population, as they were authorized to do by the laws creating them in order to protect the public health. At least 90 per cent, of the population of this country are favorable to vaccination. Still, in certain localities in Iowa, Wisconsin, Springfield, Ohio, and Williamsport, Pa., opposition has sprung up against the enforcement of vaccination. This opposition arises from prejudice, ignorance and resentment against a supposed interference with personal liberty and the dispensations of Divine Providence. The writer, during a professional experience of over forty years, and an official sanitary experience of over thirty years, has vaccinated or personally superintended the vaccination of more than two hundred thousand individuals, and
Folic acid in pregnancy
Authors: D. Z. Kitay
Journal: JAMA (1968)

<h3>To the Editor:—</h3> Eight years have elapsed since Eastman asked why "such a fuss" should be raised about folic acid in pregnancy (<i>Obstet Gynec Survey</i><b>15</b>:22, 1960). It is alarming that his question remains critically unanswered. Recent studies continue to associate folate deficiency with pregnancy pathological conditions. Many sources propose routine administration of the vitamin during antepartum care. The lay press is beginning to comment, and pharmaceutical companies are now inserting folic acid into prenatal multivitamin capsules. Until lately, we have not been adequately exposed to more reserved comment that questions the role of this isolated nutritional defect as a proximate cause of reproductive casualty. Folic acid deficiency anemia in pregnancy, caused by defects in ingestion, use, and by increased demand for the vitamin, is well defined. The socioeconomically deprived (ingestion defect) multiparous epileptic receiving anticonvulsant therapy (malutilization) and bearing twins (increased demand) is a prime candidate for both
Increased levels of a TH2-type CC chemokine thymus and activation-regulated chemokine (TARC) in serum and induced sputum of asthmatics
Authors: T. Sekiya, H. Yamada, M. Yamaguchi, K. Yamamoto, A. Ishii, O. Yoshie, Y. Sano, A. Morita, K. Matsushima, K. Hirai
Journal: Allergy (2002)
MEMBERSHIP OF THE PROPRIETARY ASSOCIATION OF AMERICACOPIED FROM THE TWENTY-THIRD ANNUAL REPORT
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal