tbuckley/cabot-search huggingface dataset:
Abstract 5455: FDA-approved drug bazedoxifene as a novel inhibitor of IL-6 and IL-11/GP130 signaling for osteosarcoma therapy
Authors: Xiaojuan Wu, Jiayuh Lin
Journal: Cancer Research (2018)

Abstract Objective: IL-6/IL-11/GP130/STAT3 signaling is crucial for osteosarcoma cells and tumor survival, growth and progression. Here, we show a novel IL-6/GP130 and IL-11/GP130 inhibitor, Bazedoxifene which was reported as a FDA-approved selective estrogen receptor modulator, in osteosarcoma therapy. Methods: We treated osteosarcoma cells with different concentrations of bazedoxifene and tested expression of GP130/STAT3 signaling and the downstream genes at PCR and protein levels in different cell lines. Furthermore, cell migration and colony formation experiments were done in Bazedoxifene-treated osteosarcoma cells. To determine the in vivo activity of Bazedoxifene, we further tested the efficacy of Bazedoxifene combination treatment with temsirolimus in tumor xenografts generated from the SJSA osteosarcoma cells. Results: Bazedoxifene appeared specific to IL-6/IL-11 as phosphorylation of STAT1 and STAT3 by IFN-γ and LIF respectively were not affected by the compound. Bazedoxifene inhibited P-STAT3, P-AKT, and induced apoptosis in human osteosarcoma cell lines expressing IL-6 and IL-11. In addition, Bazedoxifene can inhibit colony formation after the drug treatments in cancer cells. This inhibition by Bazedoxifene was partially rescued by IL-6. IFN-γ and IL-4 which do not use GP130 as a receptor and do not induce P-STAT3, did not rescue Bazedoxifene-mediated inhibition. Furthermore, IL-6 but not IFN-γ could rescue the Bazedoxifene-mediated inhibition of cell viability in osteosarcoma cells. Bazedoxifene plus temsirolimus had greater inhibition in growth of SJSA tumor xenografts than single group. Conclusions: Bazedoxifene is novel and potent IL-6/GP130 and IL-11/GP130 inhibitor and has synergistic effect with temsirolimus treatment in osteosarcoma therapy. Repositioning a drug such as Bazedoxifene already approved for safety by the FDA as a novel inhibitor of IL-6/GP130 and IL-11/GP130 signaling should provide an easier path to clinical trials and have a potential to improve the outcome of osteosarcoma. Citation Format: Xiaojuan Wu, Jiayuh Lin. FDA-approved drug bazedoxifene as a novel inhibitor of IL-6 and IL-11/GP130 signaling for osteosarcoma therapy [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 5455.
Molecular Biology and Pathogenesis of Viral Myocarditis
Authors: Mitra Esfandiarei, Bruce M. McManus
Journal: Annual Review of Pathology Mechanisms of Disease (2007)

Myocarditis is a cardiac disease associated with inflammation and injury of the myocardium. Several viruses have been associated with myocarditis in humans. However, coxsackievirus B3 is still considered the dominant etiological agent. The observed pathology in viral myocarditis is a result of cooperation or teamwork between viral processes and host immune responses at various stages of disease. Both innate and adaptive immune responses are crucial determinants of the severity of myocardial damage, and contribute to the development of chronic myocarditis and dilated cardiomyopathy following acute viral myocarditis. Advances in genomics and proteomics, and in the use of informatics and biostatistics, are allowing unbiased initial evaluations that can be the basis for testable hypotheses about virus pathogenesis and new therapies.
History
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Otitis externa
Authors: Veronica Barry, Navdeep Bhamra, Edward Balai, Steven Maung
Journal: BMJ (2021)

### What you need to know A 57 year old man presents to his general practitioner with a 3 day history of severe right sided ear pain, reduced hearing, and discharge. He is a self-employed car mechanic with a small business, and has been absent from work for the past two days because of the pain and subsequent lack of sleep. He has hypertension and type 2 diabetes. Otitis externa is an infection of the skin of the outer ear canal which typically presents with severe otalgia with or without ear discharge and reduced hearing. It is a common condition with an annual incidence of 1% that affects 10% of the population during their lifetime.12 In 98% of cases the cause is bacterial, with Pseudomonas aeruginosa and Staphylococcus aureus the most common pathogens.3 Otitis externa often causes severe pain and can have a major impact on quality of life, disturbing sleep, and the ability to work or exercise. As with any primary care consultation, take a focused history to narrow down the differential diagnosis (table 1) and explore the patient’s ideas and concerns. Ask specifically about risk factors and clinical features for malignant otitis externa (box 1). This extension of the infection into the temporal bone can be easily missed and is a serious complication requiring long term intravenous antibiotic treatment. If not treated it may lead to sepsis and intracranial complications. View this table: Table 1 Differential diagnosis3 Box 1 ### Malignant otitis externa Malignant otitis externa is a rare but serious extension of otitis externa, whereby infection spreads to surrounding structures leading … RETURN TO TEXT
Anticipatory Grief
Authors: Glen W. Davidson
Journal: JAMA (1975)

<b>The Realization of Death: A Guide for the Psychological Autopsy</b>, by Avery D. Weisman, 207 pp, $10, New York, Jason Aronson, 1974. Anticipatory grief is the emotional phenomenon of bereavement prior to the actual loss of a loved one. It is important for health care workers to understand it as a clinical symptom in order to identify those high-risk individuals in whom prolonged or maladaptive grief reactions may subsequently develop. Fifty-nine researchers have contributed to the Schoenberg volume. The essays are varied both in content and quality. Some of them are already dated. But as a whole, the volume is a significant addition to the growing literature on enlightened health care for the terminally ill patient and his family. No small credit must go to The Foundation of Thanatology, which sponsored the volume. Avery Weisman's contribution, "Is Mourning Necessary?" is one of the better essays and his title captures the
National Institutes of Health consensus report on precursors to malignant melanoma. A difference in opinion
Authors: H. T. Lynch
Journal: JAMA (1984)

THE USE of accurate information in cancer genetics can aid the physician immeasurably in cancer-control efforts. The National Institutes of Health (NIH) consensus report dealing with precursors to malignant melanoma<sup>1</sup>failed to address certain evidence available about the genetics, tumor spectrum, and clinical facets of the natural history of the familial atypical multiple mole melanoma (FAMMM) syndrome. This term is synonymous with the hereditary dysplastic nevus syndrome (DNS) but is older and descriptive of all factors (clinical, genetic, and histological), while DNS is only a histological term. In addition, nevi may be absent, as will be discussed later, but the syndrome with its malignant potential can still be present. Thus, DNS is genetically inappropriate, as it does not describe the clinical spectrum of the FAMMM syndrome.<sup>2</sup> The report implied that the large atypical mole is distinctive of the FAMMM syndrome and is the sole cutaneous marker for this
Tracking Tuberculosis
Authors: Alan B. Bloch
Journal: JAMA (1994)

<h3>To the Editor.</h3> —We agree with Dr Bellin's support of national tuberculosis (TB) surveillance and the views that drug-resistant TB and the failure of patients to complete therapy are major concerns requiring immediate action.<sup>1</sup>Information on all 44 notifiable conditions reported to the Centers for Disease Control and Prevention (CDC) is provided for statistical purposes only and includes no personal identifiers. If patients and health care providers are to continue to cooperate with national disease surveillance, they need to be reassured of the confidentiality of the information collected. For two of the conditions reported to the CDC (human immunodeficiency virus/acquired immunodeficiency syndrome [HIV/AIDS] and TB) patients are also protected by an assurance of confidentiality under §308(d) of the Public Health Service Act, which prohibits disclosure of any information that could be used directly or indirectly to identify patients. Reasons for this safeguard for TB and HIV/ AIDS surveillance include
Germinoma of the Mediastinum: Critical Review of Classification of Thymic Neoplasms
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Highlights
Journal: JAMA Pediatrics (2019)

Intranasal Ketamine vs Fentanyl on Pain Reduction in Children 140Frey and colleagues conducted a noninferiority randomized clinical trial of 90 children who presented to emergency departments with pain owing to traumatic limb injuries.They found that intranasal ketamine was noninferior to intranasal fentanyl for pain relief, with mean reductions in visual analog scale pain scores of 30.6 mm and 31.9 mm, respectively, at 30 minutes after intervention.Continuing Medical Education jamanetwork.com/learning Sibling Recurrence Risk of ADHD and ASD 147Miller and colleagues conducted a population-based study of 15 175 US children.They found that compared with later-born siblings of children without a diagnosis, later-born siblings of those with autism spectrum disorder (ASD) were more likely to receive a diagnosis of ASD or attention-deficit/hyperactivity disorder (ADHD).In addition, compared with later-born siblings of children without a diagnosis, later-born siblings of children with ADHD were more likely to receive a diagnosis of ADHD or ASD.
Erratum
Authors: G Adams, H Barrie, F Browne, H Clutterbuck, P Das, J Flynn, A Friedlander, H Griffiths, J Kirk, L Mcbride, P Stewart, W Thompson, T Williams, Johni Sir, Lectutreship Strut7ters, Johlnson Symingtoui
Journal: BMJ (1914)

delivered the second of the Struthers LectuLres in the Hall of the College on December 16th, the sub- ject being observations on the relations of the inner surface of the oranial wvall to the outer surface of the brain.The lecture was illustrated by specimens, casts, and photographls.
Hydroxyurea Can Be Used to Increase Mouse c-kit+Thy-1.1loLin−/loSca-1+ Hematopoietic Cell Number and Frequency in Cell Cycle In Vivo
Authors: Nobuko Uchida, Annabelle M. Friera, Dongping He, Michael J. Reitsma, Ann S. Tsukamoto, Irving L. Weissman
Journal: Blood (1997)
THE HEALTH CONFERENCE
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
&lt;TITLE&gt;Does your child have an ear infection?&lt;/TITLE&gt;
Authors: Mi Hwang, Richard Glass, Jeff Molter
Journal: JAMA (1999)

and the AMA.The information and recommendations appearing on this page are appropriate in most instances; but they are not a substitute for medical diagnosis.For specific information concerning your personal medical condition, JAMA and the AMA suggest that you consult your physician.
European Perspectives
Journal: Circulation (2009)

is a cardiologist who loves every moment of his job.If asked what his future plans are in cardiology, he enthuses, "More of the same.""It is such a fabulous job," he says."Every day is different and inspirational with something new happening; dealing with patients, going from a 3-hour chronic total occlusion case to sitting in outpatients, talking to a 78year-old lady with atrial fibrillation, and then coming back and having a research meeting.You could not ask for more variety."Yet when Professor Gershlick's medical career began in the early 1980s, he had no intention of becoming a cardiologist."The reality is that it happened by chance," he says.After training at St Mary's Hospital in London, England, and working as a junior doctor at Guy's Hospital in London, his ambition was to become a nephrologist, but when he came to seek a middle-grade post, no renal jobs were available.He recalls, "In the meantime I went to the National Heart Hospital to work as a junior doctor in cardiology, and then, when there were no posts in renal medicine at an intermediate level and because I needed to pay my mortgage, I extended my junior doctor's job at the National Heart Hospital for another 6 months.I then
Cosmetic outcome after breast conserving surgery and either external beam or intraoperative radiotherapy for early breast cancer: Objective assessment of patients from a randomized controlled trial in Lublin, Poland.
Authors: Norman R. Williams, Andrzej Kurylcio, Malgorzata Jankiewicz, Jaroslaw Romanek, Wojciech Polkowski, Nikolaos Michalopoulos, Mohammed R. Keshtgar
Journal: Journal of Clinical Oncology (2015)

1056 Background: The international randomised controlled TARGeted Intraoperative radioTherapy (TARGIT A) trial demonstrated non-inferiority between the technique of TARGIT (Intra-Operative RadioTherapy (IORT) with Intrabeam) and whole-breast external beam radiotherapy (EBRT) in women with early breast cancer. The aim of this study was to determine if the single high dose of TARGIT leads to impaired cosmesis in a group of patients in Lublin, Poland. Methods: Frontal digital photographs were taken of women participating in the TARGIT Trial at the Medical University in Lublin and analysed, blinded to treatment received, by BCCT.core software which produced overall Harris scores, and scores for various measures of symmetry, colour and scar. Results: 29 women (16 EBRT, 13 IORT), median age 56 years (range 49 to 79) had photographs taken at baseline (up to 2 days prior to surgery), then at 12m (median 364d). There were no differences in overall classification or measures of symmetry apparent between treatment groups. At 12m there was a significant difference in cEMDL, cEMDb and cX2b (see Table); these differences indicate more “redness” in the EBRT group compared with the IORT group. Conclusions: This objective assessment of aesthetic outcome in patients from a randomised trial demonstrates that “redness”, a surrogate for radiation induced erythema grade I or II, is significantly worse in patients receiving EBRT compared with those receiving IORT. This study provides further evidence that the objective scoring of cosmesis using BCCT.core is feasible and may be an approach for standardisation, and confirms an early beneficial effect of TARGIT on cosmesis. Median (first – third quartiles) of three measures of colour. Measure EBRT IORT p* cEMDL 2.15 (1.54 - 3.48) 0.69 (0.43 - 1.10) 0.002 cEMDb 0.62 (0.37 - 0.92) 0.45 (0.15 - 0.57) 0.017 cX2b 0.22 (0.12 - 0.35) 0.13 (0.03 - 0.20) 0.037 * Wilcoxon Two-Sample test, 2-sided.
Tuberculous Pericarditis
Authors: JOHN J. ROONEY
Journal: Annals of Internal Medicine (1970)

Tuberculous pericarditis is difficult to diagnose and treat and is associated with a 40% mortality. Of 35 patients with tuberculous pericarditis 6 (17%) were undiagnosed antemortem. Two groups among the 28 patients who received chemotherapy were compared: 10 patients treated with "triple therapy" alone and 18 patients treated with "triple therapy" and prednisone. Both groups were comparable in age, race, sex, and extent and duration of disease. Four patients in the first group died. Four patients required pericardiectomy, two of these improved, and two died. Four of the remaining 6 patients improved, and two died. One of the improved patients has since required pericardiectomy 5 years after initial treatment. There were no deaths in the second group; 14 improved without surgery, and 4 required adjunctive pericardiectomy. Cardiovascular complications of the inflammatory exudate in the pericardium are the major causes of death in tuberculous pericarditis. Corticoids suppress inflammation, enhance reabsorption of the effusion, and appear essential for successful therapy. Pericardiectomy is indicated for persistent enlarged heart size, progressive congestive heart failure, and increasing venous pressure when heart size is decreasing.
Masthead: (Adv. Healthcare Mater. 14/2018)
Journal: Advanced Healthcare Materials (2018)

Citizenship: Wiley's Corporate Citizenship initiative seeks to address the environmental, social, economic, and ethical challenges faced in our business and which are important to our diverse stakeholder groups.Since launching the initiative, we have focused on sharing our content with those in need, enhancing community philanthropy, reducing our carbon impact, creating global guidelines and best practices for paper use, establishing a vendor code of ethics, and engaging our colleagues and other stakeholders in our efforts.
THE CLINICAL SIGNIFICANCE OF LEUCOCYTOSIS.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lovenox Hurts
Authors: Samantha M. Jaglowski
Journal: Annals of Internal Medicine (2009)

On Being a Patient20 October 2009Lovenox HurtsSamantha M. Jaglowski, MDSamantha M. Jaglowski, MDFrom The Ohio State University, Columbus, OH 43210.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-151-8-200910200-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail When I was an intern, my program director told me that one of the things she liked best about me was my ability to stay cool under pressure. I wryly responded that maybe I just didn't have enough sense to know when to worry. We chuckled, and then I spent the next 3 years proving my point. After my first daughter was born during my second year of residency, it never occurred to me that morning sickness should resolve with the birth of the baby, if not some time before. When I started having severe positional neck pain, I blamed ... Author, Article, and Disclosure InformationAuthors: Samantha M. Jaglowski, MDAffiliations: From The Ohio State University, Columbus, OH 43210.Corresponding Author: Samantha M. Jaglowski, MD, The Ohio State University, 320 West 10th Avenue, 406C #1 Starling Loving, Columbus, OH 43210; e-mail, samantha.jaglowski@osumc.edu. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited by„Pamiętam, zdarzyło się to w sobotę rano, około 10”. Fachowe publikacje medyczne oparte na relacjach pacjentów i lekarzy 20 October 2009Volume 151, Issue 8Page: 585-586KeywordsCoffeeLesionsResidencySleepSleep deprivationSurgeryTracheotomyTwinsVertigoWheelchairs ePublished: 20 October 2009 Issue Published: 20 October 2009 Copyright & PermissionsCopyright © 2009 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...