tbuckley/cabot-search huggingface dataset:
Pocket Medical Dictionary giving the Pronunciation and Definition of the Principal Words used in Medicine and the Collateral Sciences, including very complete tables of the arteries, muscles, nerves bacteria, bacilli and micrococci, spirilli and thermometric scales and a dose list of drugs and their preparation, in both the English and metric system of weights and measures.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Polio Outbreaks Slow Progress Toward Global Eradication
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
INJURY OF THE SPINAL CORD WITH SYMPTOMS OF SYRINGOMYELIA.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Patient-Derived Xenograft Model for Identifying Therapies and Defining Mechanisms of TSLP-Induced CRLF2 Signals in Ph-like B-ALL
Authors: Olivia L Francis, Terry-Ann MIlford, Ineavely Baez, Jacqueline Coats, Christopher L. Morris, Ross Fisher, Benjamin Joseph Van Handel, Ruijun Su, Batul T. Suterwala, Shadi Farzingohar, Sinisa Dovat, Kimberly Payne
Journal: Blood (2015)
Queries and Minor Notes
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 1368: BK Channel β1 Subunits Are Specific Effectors Of Cholane-induced Channel Activation
Authors: Anna Bukiya, Ligia Toro, Alejandro M Dopico
Journal: Circulation (2007)

The activity of large conductance, Ca 2+ - and voltage-gated potassium (BK) channels in smooth muscle critically controls vascular tone. Depolarization-induced Ca 2+ -entry in the myocyte activates BK channels, which generate outward positive current that tends to repolarize the membrane, limit Ca 2+ entry and, thus, oppose contraction. Cholane-derived steroids (e.g., lithocholic acid, LC) reduce vascular tone in isolated, resistance-size rat cerebral arteries by selective activation of myocyte BK channels. In most tissues, native BK channels consist of pore-forming α (encoded by KCNMA1 or Slo1 ) and accessory β1–4 (encoded by KCNMB1–4 ) subunits. Remarkably, KCNMB expression is tissue-specific: while KCNMB1 is highly predominant in smooth muscle, KCNMB2–4 are not. Thus, agents that target BK β1 subunits may be used to selectively modulate myocyte BK channel function. After cloning the BK α subunit from rat cerebral artery myocytes (termed “cbv1”, AY330293 ), we demonstrated that homomeric cbv1 channel steady-state activity (NPo) was not affected by acute LC application. In contrast, heteromeric cbv1+β1 channel NPo was reversibly increased by LC (+290% of control at EC max ~150 μM; EC 50 =46 μM). Whether the other BK β subunits (2–4) can substitute for β1 to evoke LC-sensitivity in the BK channel remains unknown. To test this, we applied 150 μM LC to the intracellular side of inside-out patches excised from Xenopus laevis oocytes expressing cbv1 alone or cbv1 with a given BK β subunit subtype (1–4). Currents were evoked with the membrane clamped at ±20mV and free Ca 2+ i set to 10 μM, a concentration found in the cerebral artery myocyte during contraction. As previously found, LC consistently failed to increase homomeric cbv1 NPo, while drastically enhancing heteromeric cbv1+β1 channel NPo. Remarkably, LC failed to activate cbv1+β2, cbv1+β3 and cbv1+β4 heteromeric channels. In conclusion, the BK β1 (smooth muscle-type) subunit serves as a unique sensor for cholane-derived steroids. Thus, these compounds provide a platform for designing therapeutic agents to treat cardiovascular disease where reduction of vascular tone is required.
Pregnancy in cystic fibrosis of the pancreas
Authors: R. J. Grand
Journal: JAMA (1966)

Information is presently available on ten women with cystic fibrosis who have become pregnant: two patients already in the literature, two cases in this report, and six from a national survey. The toll of maternal morbidity and mortality as well as the high risk of fetal prematurity (and death) make the pregnant woman with cystic fibrosis a significant challenge in management. Important considerations must be (1) adequate prenatal evaluation and therapy of pulmonary disease, including cor pulmonale if present; (2) careful management of electrolyte problems which may arise; (3) proper nutrition and pancreatic replacement as indicated; (4) diagnosis of maternal diabetes and, in its presence, appropriate conduct of labor and the care of the newborn; and (5) early studies in the infant to note the presence or absence of cystic fibrosis. All of the 11 living infants in the present study were normal and showed no stigmata of cystic fibrosis.
Diabetes, New York
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Therapeutic Manual of the University of Michigan Hospital. A Symposium Compiled for the Convenience of Medical Students, Internes and Practitioners.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SAMUEL BARD (1742-1821) COLONIAL PHYSICIAN
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Rucaparib Approved for Ovarian Cancer
Journal: Cancer Discovery (2017)

The FDA approved the PARP inhibitor rucaparib to treat women with advanced ovarian cancer who have already been treated with at least two chemotherapies and have a BRCA1 or BRCA2 gene mutation identified by an approved companion diagnostic test. The agency also gave a nod to the FoundationFocus CDxBRCA test to detect BRCA alterations.
Occupational Exposures to Cd, Ni, and Cr Modulate Titers of Antioxidized DNA Base Autoantibodies
Authors: Krystyna Frenkel, Jerzy Karkoszka, Beverly Cohen, Boguslaw Baranski, Marek Jakubowski, Greg Cosma, Emanuela Taioli, Paolo Toniolo
Journal: Environmental Health Perspectives (1994)

This study was undertaken to establish whether occupational exposures to derivatives of carcinogenic metals evoke inflammatory immune responses, as determined by the presence of elevated titers of antibodies (Ab) that recognize oxidized DNA bases.Sera obtained from the blood of steel welders (Delaware) and from workers of the Centra Ni-Cd Battery Factory (Poznah, Poland) were analyzed by the enzyme-linked immunosor- bent assay.To determine specific and nonspecific binding, an oxidized thymidine [5-hydroxymethyl-2'-deoxyuridine (HMdU)] coupled to bovine serum albumin (HMdU-BSA) as well as mock-coupled BSA (M-BSA) were used as antigens for coating the wells of microtiter plates.Titers of anti- HMdU Ab were significantly elevated in the high Cd and Ni exposure groups (18.3 ± 3.2 vs 10.8 ± 2.1 A492/pl; p<0.05).The sera of the groups with low exposures to Cd and Ni also had enhanced titers of those Ab but those increases were not statistically significant.Interestingly, the Ab titers present in the sera of controls for Cd and Ni exposures appear to be constant regardless of the protein content.In contrast, both lightly and heavily exposed subjects exhibited Ab titers that increased with increasing protein content.When 12 randomly selected workers (4 from each of the con- trol, lightly, and heavily exposed groups) were outfitted with personal monitors, anti-HMdU Ab titers of those workers showed a significant differ- ence between the groups with light (<100 pg/mi3) and heavy (>200 pg/mi3) exposures to Cd (9.8 ± 3.7 vs 22.1 ± 3.7 A492/pl; p<0.01) and Ni (11.7 ± 1.4 vs 31.0 ± 1.8; p<0.001).Workers exposed to welding fumes exhibited higher anti-HMdU Ab titers than unexposed controls, but the difference was not statistically significant.These results point to anti-HMdU Ab as being potential biomarkers of exposure to proinflammatory and potentially carcinogenic agents.-
Melanin Pigmentation
Authors: Thomas B. Fitzpatrick, Makoto Seiji, A. David McGugan
Journal: New England Journal of Medicine (1961)

Clinical Disorders of Melanin PigmentationAlthough considerable knowledge of the biology of mammalian melanin formation is now available, the pathogenesis of only a very few of the large number of pigmentary disorders is known. Four prototypes have been selected for discussion. The conditions to be discussed (albinism, phenylketonuria, ephelides and Addison's disease) are neither the most common nor the most important, but the mechanism of the pigmentary change in each is reasonably well understood.ClassificationPigmentary disorders involving the melanocyte system can be divided on a morphologic basis into three major categories: decreased pigmentation (white or lighter than patient's normal . . .
Utilization of Biomarker Data for Clinical and Environmental Intervention
Authors: David C. Christiani
Journal: Environmental Health Perspectives (1996)

Of the 189 air toxics listed in the Clean Air Act, a substantial number are important in potentially causing adverse health effects in several organ systems.Although the major health effects are manifested as respiratory diseases, especially airways disease, these agents may cause cancer and premature mortality, probably from cardiopulmonary disease.Validated biologic markers may be useful in identifying early effects to improve our understanding of exposure-response relation- ships and clarify susceptibility.However, the knowledge obtained from epidemiologic studies uti- lizing these new molecular tools will reduce morbidity and mortality from air toxics only when they can be applied effectively in the prevention and control of disease.Intervention strategies using these markers can be used to identify etiologic factors and assess the effectiveness of exposure reduction, and, in some instances, chemoprevention.This paper illustrates examples of these intervention strategies and reviews the current strengths and limitations of environmental molecular epidemiology in controlling disease caused by air toxics.
Fatal Occupational Injuries—United States, 1980-1997
Journal: JAMA (2001)

Data from the annual Census of Fatal Occupational Injuries (CFOI), collected by the Bureau of Labor Statistics (BLS), provide information on fatal occupational injuries that occur in the United States. CDC's National Institute for Occupational Safety and Health (NIOSH) uses CFOI data to support research and evaluation activities related to the National Occupational Research Agenda (NORA), a partnership between the public and private sectors to encourage workplace safety and health research. Since 1992, when BLS first introduced CFOI, BLS has annually reported data on fatal occupational injuries from all 50 states and the District of Columbia. For 2005, BLS reported a total of 5,702 work-related fatal injuries and a rate of 4.0 deaths per 100,000 workers; compared with 1992, this represents an 8% decline in the number of deaths (from 6,217 in 1992) and a 23% decline in the fatality rate (from 5.2 in 1992). This report summarizes the 2005 data, which indicated that the highest percentages of fatal workplace injuries were attributed to highway incidents, followed by falls, being struck by an object, and homicides. Since 1992, the number of deaths resulting from highway incidents, falls, and being struck by an object has increased, and the number of homicides has decreased. To reduce the number of workplace deaths, transportation measures targeting workers (e.g., truck safety and highway work-zone safety) should be enhanced by state and local transportation agencies and coordinated with highway-safety measures for the general public.
C-reactive protein elevation is common in rheumatic mitral valve stenosis and inversely correlates with success of percutaneous balloon mitral valve commissurotomy Richard A. Krasuski, Charles E. Mayes, John J. Warner, Andrew Wang, Katherine Kisslo, Cynthia Pierce, Karen Pieper, J. Kevin Harrison, Thomas M. Bashore. Duke University Medical Center, Durham, NC
Journal: Journal of the American College of Cardiology (2001)
PULMONARY EMBOLISM
Authors: S S LEOPOLD
Journal: Annals of Internal Medicine (1948)

Case Reports1 January 1948PULMONARY EMBOLISMSIMON S. LEOPOLD, M.D., F.A.C.P.SIMON S. LEOPOLD, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-28-1-172 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt has long been recognized that thrombi originating in the right side of the heart constitute a frequent threat of pulmonary embolism.Many generations of medical students have been taught that sudden tragic deaths from massive pulmonary embolism following laparotomy, or occurring post-partum, resulted from thrombosis of the pelvic veins. An appreciable mortality which varied little in major clinics was thought to be inevitable and unavoidable.In the past three years, it has been demonstrated beyond reasonable doubt that thrombosis of the deep veins of the legs is the usual cause of postoperative pulmonary embolism.Thrombophlebitis complicating certain acute infections,...Bibliography1. ALLENLINTONDONALDSON AWRRGA: Thrombosis and embolism, review of 202 patients treated by femoral vein interruption, Ann. Surg., 1943, cxviii, 728. CrossrefGoogle Scholar2. ALLENLINTONDONALDSON AWRRGA: Venous thrombosis and pulmonary embolism, Jr. Am. Med. Assoc., 1945, cxxviii, 397. CrossrefGoogle Scholar3. ALLEN AW: Thrombosis and embolism, Bull. New York Acad. Med., 1946, xxii, 169. Google Scholar4. CASTLEMAN B: Quoted Ibid.2 Google Scholar5. LEOPOLD SS: Respiratory diseases, The Cyclopedia of Med., Surg. and Specialties, Service Vol., 1946, F. A. Davis Co., Philadelphia, Pa. Google Scholar6. HAMMAN L: Embolism, thrombosis and infarction, Oxford Med., ii, 1940, Oxford Univ. Press, New York City, p. 62. Google Scholar7. OCHSNERDEBAKEY AM: Thrombophlebitis; role of vasospasm in the production of clinical manifestations, Jr. Am. Med. Assoc., 1945, cxxviii, 397. Google Scholar8. HOMANS J: Thrombosis of the deep veins of the lower leg causing pulmonary embolism, New Eng. Jr. Med., 1934, ccxi, 993. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania*Received for publication June 1, 1946.From the Medical Division of the Hospital of the University of Pennsylvania. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 January 1948Volume 28, Issue 1Page: 172-181KeywordsConvalescenceEdemaFeversHeartLaparotomyMortalityPatient advocacyPulmonary embolismThoraxVeins ePublished: 1 December 2008 Issue Published: 1 January 1948 PDF downloadLoading ...
Endometrial assessment.
Authors: M E Paterson, D W Sturdee, M Thom, J W Studd
Journal: BMJ (1978)

2-36 mmol/l (1-6 mg/100 ml) if the 12-hour steady-state serum lithium level was main- tained at 1 mmol/l."i The mean dosage of Priadel required to maintain this level would be 1643 mg.Comparison of these results suggests that the peak serum lithium level would be certainly above 2 mmol/l (1-4 mg/100 ml) and probably considerably above this in the patient described, as the patient was receiving a higher dosage of lithium.If the blood samples were taken just before administration of the whole dose of lithium, the peak serum lithium level would be even higher than this.We still do not know how best to give lithium to maintain prophylaxis, but in view of the recent reports of renal damage following lithium toxicity7 8 it is prudent to give lithium in such a way as to avoid levels in the toxic range.The majority of patients should receive lithium in at least a divided dose schedule.