tbuckley/cabot-search huggingface dataset:
index to advertisers
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Age, Intensity of Treatment, and Surviving Serious Illness
Journal: Annals of Internal Medicine (1999)

Summaries for Patients16 November 1999Age, Intensity of Treatment, and Surviving Serious IllnessSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-131-10-199911160-00040 SectionsAboutFull Text ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?When they have a serious illness, older people tend to do worse than younger ones do. Some people think this may be, in part, because older people tend to get less intense treatment than younger ones.Why did the researchers do this particular study?The researchers wanted to examine the link between age and the likelihood of surviving a major illness. They wanted to see if the intensity of treatment played a role in this relationship.Who was studied?The researchers studied 9105 patients who were hospitalized with ... Author, Article, and Disclosure InformationThe summary below is from the full report titled “Older Age, Aggressiveness of Care, and Survival for Seriously Ill, Hospitalized Adults.” It is in the 16 November 1999 issue of Annals of Internal Medicine (volume 131, pages 721-728). The authors are M.B. Hamel, R.B. Davis, J.M. Teno, W.A. Knaus, J. Lynn, F. Harrell Jr., A.N. Galanos, A.W. Wu, and R.S. Phillips, for the SUPPORT Investigators.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoOlder Age, Aggressiveness of Care, and Survival for Seriously Ill, Hospitalized Adults Mary Beth Hamel , Roger B. Davis , Joan M. Teno , William A. Knaus , Joanne Lynn , Frank Harrell Jr. , Anthony N. Galanos , Albert W. Wu , and Russell S. Phillips , for the SUPPORT Investigators Metrics 16 November 1999Volume 131, Issue 10 Page: 721 Keywords Heart failure Liver Lung and intrathoracic tumors Social status ePublished: 15 August 2000 Issue Published: 16 November 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.Loading ...
British Journal of Clinical Practice, London
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Isotopes To Be Shot, Lab To Bedside
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Viral compartmentalization and carcinogenesis at single-cell level in HBV-induced hepatocellular carcinoma
Authors: Antonio Saviano, Frank Jühling, Eloi Verrier, Hussein El Saghire, Laura Heydmann, Clara Ponsolles, Emilie Crouchet, Emanuele Felli, Patrick Pessaux, Nathalie Pochet, Catherine Schuster, Thomas Baumert
Journal: Journal of Hepatology (2020)
The Hip
Authors: Reginald R. Cooper
Journal: JAMA (1977)

This issue brings a welcome respite from the recent surfeit of volumes devoted exclusively to routine total hip replacement. The introductory chapter on historical milestones in the development of modern surgery of the hip by Dr A. R. Shands, Jr, perhaps the current "chief orthopaedic historian in America," provides an interesting and informative perspective against which one can view our present surgical approaches to hip disease. In view of his discussions and recent trends, I wonder if the history of hip surgery, too, will repeat itself. An excellent review on the management of aseptic necrosis delineates a variety of treatment methods for this perplexing riddle. The remaining chapters provide useful information on the treatment of difficult hip problems that fail to conform to "textbook patterns." Discussions of femoral shortening and osteotomy, pelvic osteotomy, and acetabular osteotomy remind us that the effective and predictable treatment of congenital hip disease in the
Re: Meelan Bul, Xiaoye Zhu, Antti Rannikko, et al. Radical Prostatectomy for Low-Risk Prostate Cancer Following Initial Active Surveillance: Results From a Prospective Observational Study. Eur Urol. In press. http://dx.doi.org/10.1016/j.eururo.2012.02.002
Authors: Ferhat Ates, Ilker Akyol, Hasan Soydan
Journal: European Urology (2012)
Biomonitoring of 1,3-Butadiene and Related Compounds
Authors: Siv Osterman-Golkar, James A. Bond
Journal: Environmental Health Perspectives (1996)

The 1990 Clean Air Act Amendments list several volatile organic chemicals as hazardous air pollutants, including ethylene oxide, butadiene, styrene, and acrylonitrile.The toxicology of many of these compounds shares several common elements such as carcinogenicity in laboratory ani- mals, genotoxicity of the epoxide intermediates, involvement of cytochrome P450 for metabolic activation (except ethylene oxide), and involvement of at least two enzymes for detoxication of the epoxides (e.g., hydrolysis or conjugation with glutathione).These similarities facilitate research strategies for identifying and developing biomarkers of exposure.This article reviews the current knowledge about biomarkers of butadiene.Butadiene is carcinogenic in mice and rats, which raises concern for potential carcinogenicity in humans.Butadiene is metabolized to DNA- reactive metabolites, including 1,2-epoxy-3-butene and diepoxybutane.These epoxides are thought to play a critical role in butadiene carcinogenicity.Butadiene and some of its metabolites (e.g., epoxybutene) are volatile.Exhalation of unchanged butadiene and excretion of butadiene metabolites in urine represent major routes of elimination.Therefore, biomonitoring of butadiene exposure could be based on chemical analysis of butadiene in exhaled breath, blood levels of butadiene epoxides, excretion of butadiene metabolites in urine, or adducts of butadiene epoxides with DNA or blood proteins.Mutation induction in specific genes (e.g., HPRT) following butadiene exposure can be potentially used as a biomarker.Excretion of 1,2-dihydroxy-4-(N-acetylcysteinyl-S)butane or the product of epoxybutene with N-7 in guanine in urine, epoxybutene-hemoglobin adducts, and HPRT mutation have been used as biomarkers in recent studies of occupational exposure to butadiene.Data in laboratory animals suggest that diepoxybutane may be a more important genotoxic metabolite than epoxybutene.Biomonitoring methods need to be developed for diepoxybutane and other putative reactive butadiene metabolites.With butadiene and related compounds, the ultimate challenge is to identify useful biomarkers of exposure in which quantita- tive linkages between exposure and internal dose of the important DNA-reactive metabolites are established.
Erratum to: Design, conduct, analysis and reporting of a multi-national placebo-controlled trial of activated protein C for persistent septic shock
Authors: Simon Finfer, V. Marco Ranieri, B. Taylor Thompson, Philip S. Barie, Jean-François Dhainaut, Ivor S. Douglas, Bengt Gårdlund, John C. Marshall, Andrew Rhodes
Journal: Intensive Care Medicine (2010)
Interim safety analysis of a novel induction chemotherapy (IC) regimen of weekly nanoparticle albumin-bound (nab-)paclitaxel and cetuximab with every 3 week cisplatin and 5-FU in patients with locally advanced nonmetastatic head and neck squamous cell carcinoma (HNSCC).
Authors: B. A. Van Tine, J. Ley, B. Nussenbaum, W. L. Thorstad, H. Gay, T. Rachocki, J. Subramanian, D. I. Kuperman, D. Adkins
Journal: Journal of Clinical Oncology (2010)

5564 Background: Achievement of favorable response at the primary tumor site to IC (with cisplatin and 5-FU) correlates with disease control after subsequent definitive radiation-based therapy (RT) in patients with HNSCC. SPARC, an albumin binding protein that is commonly over-expressed in HNSCC, may facilitate preferential accumulation of nab-paclitaxel at tumor sites compared to other formulations of paclitaxel. Methods: An objective of this prospective phase 2 trial was to determine the safety of an IC regimen of weekly nab-paclitaxel (100 mg/m2) and cetuximab (250 mg/m2) with every 3 week cisplatin (75 mg/m2) and 5-FU (750 mg/m2 per day ×3 CIVI) (ACCF) given for three cycles (over 9 weeks) in patients with locally advanced HNSCC. Patients then were treated with definitive chemoradiation. The assessment of adverse events (AE) occurred weekly during ACCF and was graded using NCI-CTC criteria. The incidence of grade 3/4 toxicity in patients with this IC regimen was expected to be 15% and the maximum allowable incidence was 35%. The preplanned stop rule was to suspend the study for review if 5 among the first 10 patients developed any grade 3/4 AE. This interim safety analysis occurred after 10 patients were enrolled. Results: All ten enrolled patients completed ACCF. Three of 10 patients experienced any grade 3/4 AE. The majority of the grade 3/4 AEs occurred in one patient (who recovered with only mild renal dysfunction as a long term sequela). Two other patients experienced at least one grade 3/4 AE: transient asymptomatic neutropenia and calf thrombosis. Thus, 3 of 10 patients experienced any grade 3/4 AE. A review of all grades of AE noted that 4 of 10 patients experienced renal dysfunction (most grades 1/2), resulting in a protocol amendment to include additional IV fluids after Cisplatin. One patient experienced peripheral neuropathy (grade 1). Conclusions: The preplanned safety analysis of the first 10 patients treated with ACCF did not identify an unexpectedly high frequency of serious grade 3/4 AE's. No significant financial relationships to disclose.
Heavy Toll From Alcohol
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Haemodialysis Disequilibrium
Authors: A. C. Kennedy, A. L. Linton, R. G. Luke
Journal: BMJ (1964)

sive cervical-smear specialists should realize that carcinoma may be present in other parts of the urogenital system and, of course, else- where.The only symptom that this patient had had was two rather excessive periods.-Iam, etc,, West Harrow,
MISCELLANEA MEDICA
Journal: JAMA (1982)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MALARIAL HEMOGLOBINURIA
Authors: WALTER V. BREM
Journal: JAMA (1906)

<h3>ANALYSIS AND DISCUSSION OF CASES.</h3><h3>ETIOLOGY.</h3><h3>Nationality.</h3> —Nine of the cases occurred in Americans, two in Spaniards, one in an Italian, one in a Greek, and one in a Spanish-American. Of the 1,107 malarial patients admitted during the period covered, the Teutonic race constituted 53.6 per cent.; Spaniards, 24.4 per cent.; Italians, 4.7 per cent.; Spanish-Americans, 5.6 per cent.; Greeks,.7 per cent.; seventeen other countries represented, 11 per cent. Hemoglobinuria developed, then, in about 1 out of every 66 Teutonic malarial patients; in 1 out of every 135 Spaniards; in 1 out of 52 Italians; in 1 out of 62 Spanish-Americans, and in 1 out of 5 Greeks. Among 122 representatives of seventeen other world-scattered countries no case occurred. <h3>Age.</h3> —Seven cases occurred during the third decade, four during the fourth, three during the fifth. In the 1,107 malarial cases the incidence by decades was as follows: Third decade, 1
Abstract 1982: In Vivo Virtual Histology Intravascular Ultrasound Correlates of Risk Factors for Sudden Coronary Death in Men: Results from the Prospective, Global, Multi-center VH-IVUS Registry
Authors: Eduardo Missel, Gary S Mintz, Stephane G Carlier, Jie Qian, Shoujie Shan, Celia Castellanos, Ryan K Kaple, George Dangas, Roxana Mehran, Jeffrey W Moses, Gregg W Stone, Martin B Leon
Journal: Circulation (2007)

Background: Histopathological data shows that cigarette smoking and a total-cholesterol-to-high-density-lipoprotein ratio (TC/HDL) &gt;5 are associated to sudden coronary death (SCD) in men. We hypothesized a relationship between virtual histology intravascular ultrasound (VH-IVUS) findings and these risk factors. Methods and Results: We performed whole pullback VH-IVUS analyses in a consecutive series of 473 male pts and measured the four basic VH-IVUS coronary plaque components - fibrous (FI), fibro-fatty (FF), dense calcium (DC) and necrotic core (NC) - as well as calculated a NC/DC ratio. Pts age was 61±11years, with 27% current smokers and 69% with a lipid disorder. Among VH-IVUS parameters, the NC/DC ratio was the only parameter related both to the TC/HDL ratio (r=0.18, p=0.0008) and LDL-C levels (r=0.17, p=0.002); it had a negative correlation with HDL-C levels (r=0.11, p=0.03), and was significantly higher for smokers [median: 1.98 (1.35, 3.18)] vs. non-smokers [median: 1.70 (1.23, 2.53), p=0.006]. A NC/DC value &gt;3 was the threshold that best identified smokers with a TC/HDL&gt;5 (odds ratio 3.0, p=0.0001). ROC curves showed superiority of the NC/DC ratio (A 2 : 0.64, p&lt;0.0001) over %DC (A 2 : 0.58, p=0.006) or %NC (A 2 : 0.51, p=0.43) as isolate parameters to identify pts with a risk profile for SCD (Figure ). Conclusions: In diseased coronary segments the ratio of necrotic core to calcification detected by VH-IVUS is related to previously-published pathologic risk factors for SCD.
Reproductive toxicology. Propylene glycol.
Authors: James Lamb, Ntp Niehs, Dushyant Gulati, Leta Barnes, Marian Welch
Journal: Environmental Health Perspectives (1997)

Propylene glycol (PG), a common solvent used in industry, food, and in consumer goods, was tested for reproductive toxicity in Swiss CD-1 mice using the RACB protocol (Morrissey et al., Fundam Appl Toxicol 13:747-777 [1989]).It was part of a series of glycol ethers and congeners eval- uated for structure-activity correlations using this design.Data collected on body weights, clinical signs, and food and water consumption during the dose-range-finding segment (Task 1) were used to set concen- trations for the main study (Task 2) at 0.0, 1.0, 2.5, 5.0% PG in drinking water.These concentrations produced calculated con- sumption estimates of approximately 1.819, 4.796, and 10.1 18 g/kg body weight/day.
Abstract 2334: Head-to-head Comparison of Whole-Heart Coronary MR and 40/64 slice Multidetector-CT Angiography for Detection of Coronary Artery Stenosis.
Authors: Anne-Catherine Pouleur, Jean-Benoit le Polain de Waroux, Joelle Kefer, Céline Goffinet, Jean-Louis Vanoverschelde, Bernhard L Gerber
Journal: Circulation (2007)

Purpose . Whole-heart magnetic resonance coronary angiography (WH-MRCA) has been recently proposed for non-invasive coronary imaging. Early studies have suggested that WH-MRCA might have similarly high diagnostic accuracy for detection of coronary disease as multidetector CT (MDCT). Yet, no direct comparison between both techniques has been performed. The aim of the present study was therefore to perform a head-to-head comparison of both techniques for detection of significant coronary stenoses using invasive cardiac catheterization as reference standard. Methods. Seventy-seven consecutive patients (56 M, 61±14 years) prospectively underwent free-breathing 3-dimensional WH-MRCA and 40/64-slice MDCT before cardiac catheterization. WH-MRCA and MDCT images were visually graded by 2 blinded observers and the diagnostic accuracy of both methods for detecting &gt;50% luminal diameter stenoses (DS) in segments and vessels &gt;1.5 mm size was compared using quantitative angiography (QCA) as reference method. Results. MDCT was successfully completed in all 77 patients in &lt; 5 minutes. By contrast, WH-MRCA failed in 9 patients (12%) because of poor navigator performance and lasted 20±4 minutes (p&lt;.01 vs MDCT). According to QCA, out of 992 segments &gt; 1.5 mm diameter, 49 presented &gt;50% DS. If all segments including non interpretable segments were considered, WH-MRCA had lower sensibility (35/49 or 71% vs. 45/49 or 92%, p&lt;0.001), lower specificity (644/943 or 68% vs. 863/943 or 92%, p&lt;0.001) and accuracy (679/992 or 68% vs. 908/992 or 92%, p&lt;0.001) for detection of coronary stenosis than MDCT. However if only interpretable segments were considered, the sensitivity (35/37 or 95% vs. 45/46 or 98%, p=0.58), specificity (644/689 or 93% vs. 863/917 or 94%, p=0.67) and diagnostic accuracy (679/726 or 94%, vs. 908/963 or 94%, p=0.58) of WH-MRCA and MDCT for detection of &gt;50% DS was similar. This was also the case on per-vessel basis. Conclusion. In the present study, MDCT had higher success rate than WH-MRCA. Therefore on an intention to diagnose basis, MDCT was superior to WH-MRCA. However, the diagnostic accuracy of WH-MRCA on per-segment and per-vessel basis was not statistically different from MDCT if only interpretable segments were considered.
Losing Touch
Authors: June Goodwin
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal