tbuckley/cabot-search huggingface dataset:
Clinical use of an implantable standby pacemaker
Authors: V. Parsonnet
Journal: JAMA (1966)

A completely implantable pacemaker that will not compete with naturally occurring conducted beats has been used in five patients. An external model of the same design was successfully used in an additional 12 patients. The implantable model, inserted transvenously, has a single cathode in the right ventricle and an anodal plate on the surface of the power pack. The cathode serves as the sensing probe as well as the driving electrode. Although, to our knowledge, this is the first description of such an implantable device, Lemberg previously described an external "demand" pacemaker.<sup>1</sup> The merits of transvenous pacing will not be discussed here. Reference can be made to the original work of Furman et al<sup>2</sup>for unipolar pacing and Parsonnet et al<sup>3</sup>for bipolar pacing. The use of an implantable pacemaker attached to a permanent transvenous electrode has been reported by the authors and by other investigators.<sup>4</sup>
Dynamics of people without health insurance. Don't let the numbers fool you
Authors: K. Swartz
Journal: JAMA (1994)

IS THE "problem" of people without health insurance really a problem? Opponents of major health care reform argue no. The<i>Wall Street Journal</i>says, "[T]he alleged 37 million uninsured also wilts under analysis.... Studies show that 70 percent of them are uninsured for less than nine months."<sup>1</sup>The Council for Affordable Health Insurance says if everyone were offered a medical savings account, "the numbers [sic] of uninsured could be reduced by as much as 25 million" (from 37 million) because "most (70%) of the uninsured remain without coverage for less than one year."<sup>2</sup>Statistics that describe dynamics—people moving in and out of a particular condition—can mislead even with the best of intentions. When intentions are not the best, the statistics can totally confuse. I write as one of the researchers who estimated the distribution of uninsured spell lengths that yields the findings that the median spell length is
Ipecac in Uterine Inertia.—
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Textbook of Obstetrics
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Programs in medical education sponsored by government agencies
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Metyrapone test with adrenocorticotrophic levels. Separating primary from secondary adrenal insufficiency
Authors: L. I. Dolman
Journal: JAMA (1979)

Basal plasma adrenocorticotrophic hormone (ACTH) and cortisol concentrations as well as plasma ACTH and 11-deoxycortisol responses to the administration of a single dose of metyrapone were evaluated in 104 patients with intact pituitary-adrenal axis, in 20 patients with secondary adrenal insufficiency, and in seven patients with primary adrenal insufficiency. In patients with primary adrenal insufficiency, baseline ACTH levels were high. Following metyrapone administration, 11-deoxycortisol concentrations were low and ACTH levels did not change. In patients with secondary adrenal insufficiency, baseline plasma ACTH levels were normal, but neither 11-deoxycortisol nor ACTH levels increased in response to metyrapone. The metyrapone test is not only useful to screen for adrenal insufficiency, it is also useful to differentiate a primary from a secondary cause. (<i>JAMA</i>241:1251-1253, 1979)
Diagnostic accuracy and appropriateness of care for seborrheic keratoses. A pilot study of an approach to quality assurance for cutaneous surgery
Authors: R. S. Stern
Journal: JAMA (1991)

In 1985 there were more than 40 million visits for ambulatory surgical procedures in the United States. Although benign cutaneous lesions are among the most frequent conditions to receive surgical treatment in ambulatory settings, their treatment is seldom subject to peer review. In this pilot study we assessed diagnostic accuracy and appropriateness of care using information available from the surgical pathology laboratory. We assessed these two measures of physician performance for 527 seborrheic keratoses removed by 133 clinicians affiliated with four different institutions. Overall, a correct preoperative diagnosis was provided in only 49% of cases. Dermatologists had the highest diagnostic accuracy (61% vs 35% for all other physicians). An appropriate procedure for the actual pathological diagnosis was performed in only 50% of cases. Lesions with a correct preoperative diagnosis were more than eight times more likely to receive appropriate care. Our data suggest that many clinicians fail to note a correct diagnosis of common cutaneous lesions before surgical removal, and many patients are treated with procedures that are more invasive than necessary for the final pathological diagnosis. Because the approach used in this pilot study relies on data already available, it has promise as a low-cost method of monitoring the quality of care of ambulatory surgery. (<i>JAMA</i>. 1991;265:74-77)
Epidermal progenitors give rise to Merkel cells during embryonic development and adult homeostasis
Authors: Alexandra Van Keymeulen, Guilhem Mascre, Khalil Kass Youseff, Itamar Harel, Cindy Michaux, Natalie De Geest, Caroline Szpalski, Younes Achouri, Wilhelm Bloch, Bassem A. Hassan, Cédric Blanpain
Journal: The Journal of Experimental Medicine (2009)
Weight loss with knee and ankle pain and swelling
Authors: J. Twersky
Journal: JAMA (1976)

<h3>History</h3> A 47-year-old man was seen for pain in both knees. For the past year, he had noted swelling of both ankles and pain and swelling of both knees. He had been seen by another physician six months previously, and a diagnosis of rheumatoid arthritis was made on the basis of the clinical symptoms. A regimen of indomethacin (Indocin) and aspirin was begun, but there was no clinical improvement. During the past year he had lost 6.7 kg. The patient denied pulmonary or gastrointestinal symptoms. Results of a physical examination were normal except for the findings in the extremities. Effusions of both knees and ankles were present. The knees were warm and tender, and there was limitation of motion of both knees due to pain. There was no evidence of clubbing, rash, or subcutaneous nodules. Pertinent laboratory data included the following: erythrocyte sedimentation rate, 51 mm/hr; lupus erythematosus (LE) preparation,
Pigmented Meningioma
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
After Polio
Authors: Glenda Cassutt
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prescription charges and tuberculosis.
Authors: H South Shields
Journal: BMJ (1968)

foetal abnormality, is praiseworthy.But who can delude himself that these will be the main problems ?The majority will consist of per- fectly healthy women who are pregnant, in or out of wedlock, and who want to be rid of the baby.It is piously stated that " a doctor-patient relationship will be created and the doctor will then advise."What in fact will happen in these cases is that the woman will tell the doctor what she wants -an abortion, with the threat that if not she will go out of her mind and possibly kill her- self.I have, indeed, already had a request on these lines from a woman who believed the Act was already in force.She did not get her request, but I was told that she knew of others in similar circumstances, but nearer London, whose doctors had been more obliging.It must be admitted that without the word " grave " there is more strain and risk men- tally and physically in bearing a child and caring for it,-but I am sure the Act was not originated to relieve people of their responsibilities.If it was the idea that abortion is preferable to an unwanted child, then go ahead, abort, but do not be under any mis- conception that it is the doctor's decision.It is the woman's decision, and the doctor merely helps her carry it out.Abortion on demand ?Certainly, and without payment.
TRTH-07. THE DISTRIBUTION, CLEARANCE AND TOXICITY OF PANOBINOSTAT ADMINISTERED TO JUVENILE RAT AND PIG BRAINSTEM BY CONVECTION ENHANCED DELIVERY
Authors: WGB Singleton, AS Bienemann, M Wooley, D Johnson, O Lewis, MJ Wyatt, LJ White, SJP Damment, C Killick-Cole, DJ Asby, SS Gill
Journal: Neuro-Oncology (2017)

The pan-histone deacetylase inhibitor panobinostat has preclinical efficacy against DIPG and the oral formulation has entered a phase one clinical trial. However, panobinostat does not cross the blood brain barrier in humans. Convection enhanced delivery (CED) is a novel neurosurgical drug delivery technique that bypasses the blood brain barrier and is of considerable clinical interest in DIPG. We investigated the toxicity, distribution and clearance of a water-soluble formulation of panobinostat in small and large animal models of CED. 30 juvenile male Wistar rats received panobinostat administered to the pons by CED at increasing concentration and were compared to animals that received vehicle alone. Clinical observation continued for two weeks. Animals were sacrificed at 72 hours or two weeks following treatment and the brains were subjected to neuropathological analysis. A further 6 animals received panobinostat by CED to the striatum and were sacrificed zero, two or six hours after infusion, their brains explanted and snap-frozen. Brainstem drug concentration was determined by LC-MS/MS. Large animal toxicity was investigated using a clinically relevant MRI guided translational porcine model of CED using a drug delivery system designed for human use. 30 μM panobinostat was administered to the ventral pons of two juvenile Large White/Landrace-cross pigs and subject to clinical and neuropathological analysis compared to control after one or two weeks. Drug distribution was determined by LC-MS/MS in porcine white and gray matter immediately after CED. There were no clinical or neuropathological signs of toxicity up to an infused concentration of 30 μM in both small and large animal models. The half-life of panobinostat in rat brain after CED was 3 hours and the drug was observed to distribute in porcine white and gray matter with a volume infusion/distribution ratio of two and three respectively. CED of water-soluble panobinostat warrants investigation in children with DIPG.
Highlights
Journal: JAMA Psychiatry (2014)

Gur and colleagues used a computerized 1-hour battery, administered to a prospective cohort of more than 9000 genotyped and psychiatrically phenotyped youths aged 8 to 21 years, to demonstrate the feasibility of creating "growth charts" of neurocognition that can identify developmental delay in children as young as 8 years with psychosis spectrum features.The delay is less severe in females than in males and more severe in children who endorse significant psychotic symptoms than in those with mild symptoms.
Evaluating estrogen for Alzheimer disease poses ethical and logistical challenges
Authors: A. A. Skolnick
Journal: JAMA (1997)

RESEARCHERS who design or conduct treatment or prevention trials for Alzheimer disease (AD) are facing some logistical difficulties and sticky ethical dilemmas. This is especially so for placebocontrolled trials that seek to determine whether estrogen can prevent or treat AD and other dementias. Although laboratory and epidemiologic studies and several small clinical trials suggest that estrogen may help prevent AD and may even improve cognitive function in women with dementia, most experts agree that randomized, double-blind, placebo-controlled trials are needed to establish the benefits and risks of the hormone used for this purpose. Two such national trials are now under way. Both have had trouble recruiting patients, and both raise questions about the ethics of giving postmenopausal women a placebo instead of a hormone that many physicians and patients believe may prevent morbidity and mortality. Although the evidence that estrogen helps prevent bone loss in postmenopausal women is fairly convincing,
Corrected Data in Table and Clarification of Rationale
Journal: JAMA (2014)

Paul A. James, MD; Suzanne Oparil, MD; Barry L. Carter, PharmD; William C. Cushman, MD; Cheryl Dennison-Himmelfarb, RN, ANP, PhD; Joel Handler, MD; Daniel T. Lackland, DrPH; Michael L. LeFevre, MD, MSPH; Thomas D. MacKenzie, MD, MSPH; Olugbenga Ogedegbe, MD, MPH, MS; Sidney C. Smith Jr, MD; Laura P. Svetkey, MD, MHS; Sandra J. Taler, MD; Raymond R. Townsend, MD; Jackson T. Wright Jr, MD, PhD; Andrew S. Narva, MD; Eduardo Ortiz, MD, MPH
Contents
Authors: Jin-Young Lee, Hyang-Ki Cho, Young Kwon, Daniel Montes-Cortes, Juan Hicks, Guillermo Ceballos-Reyes, Jose Garcia-Sanchez, Rafael Medina-Navarro, Ivonne Olivares-Corichi, Chengya Liang, Kristi Decourcy, Mary Prater, Aki Shinoki, Hiroshi Hara, Keisho Katayama, Kazushige Goto, Koji Ishida, Futoshi Ogita, Yi Wang, Xiaojie Li, Yuming Guo, Lawrence Chan, Xinfu Guan, Cemal Ercin, Teoman Dogru, Serkan Tapan, Muammer Kara, Cem Haymana, Nuri Karadurmus, Yıldırım Karslioglu, Cengizhan Acıkel
Journal: Metabolism (2010)
Healthier Mothers and Babies--1900-1999
Journal: JAMA (1999)

At the beginning of the 20th century, for every 1000 live births, six to nine women in the United States died of pregnancy-related complications, and approximately 100 infants died before age 1 year. From 1915 through 1997, the infant mortality rate declined >90% to 7.2 per 1000 live births, and from 1900 through 1997, the maternal mortality rate declined almost 99% to <0.1 reported death per 1000 live births (7.7 deaths per 100,000 live births in 1997). Environmental interventions, improvements in nutrition, advances in clinical medicine, improvements in access to health care, improvements in surveillance and monitoring of disease, increases in education levels, and improvements in standards of living contributed to this remarkable decline. Despite these improvements in maternal and infant mortality rates, significant disparities by race and ethnicity persist. This report summarizes trends in reducing infant and maternal mortality in the United States, factors contributing to these trends, challenges in reducing infant and maternal mortality, and provides suggestions for public health action for the 21st century.
Highlights
Journal: JAMA (2013)

Effect of CPAP on Blood Pressure in Patients With OSA 2407Many patients with resistant hypertension have obstructive sleep apnea (OSA).To assess the effect of continuous positive airway pressure (CPAP) treatment on blood pressure in these patients, Martínez-García and colleagues randomly assigned 194 patients with resistant hypertension and OSA to receive 12 weeks of CPAP or no CPAP therapy with no changes made in blood pressure medications.The authors report that patients receiving CPAP treatment experienced a decrease in 24-hour mean and diastolic blood pressure and an improvement in the nocturnal blood pressure pattern. Weight Change and Health 3 Years After Obesity Surgery 2416Little is known about long-term weight loss and health outcomes after bariatric surgery.In a 3-year follow-up of 2458 adults who underwent Roux-en-Y gastric bypass (RYGB) or laparoscopic adjustable gastric banding (LAGB) for severe obesity, Courcoulas and colleagues found that median weight loss was 41 kg for RYGB and 20 kg for LAGB participants, with the majority experiencing maximum weight change during the first year.Improvements in comorbid hyperglycemia, hyperlipidemia, and hypertension were variable but of greater magnitude with RYGB than LAGB.In an Editorial, Ikramuddin and Livingston discuss outcomes of bariatric surgery.
Applicants Received Passing Grades.
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
KOCH'S WISDOM.
Journal: JAMA (1890)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal