tbuckley/cabot-search huggingface dataset:
God at the Bedside
Authors: Jerome Groopman
Journal: New England Journal of Medicine (2004)

Not long ago, in the oncology clinic where I work, my patient Anna Angelo asked me to pray to God. At the time, prayer was far from the forefront of my mind. Anna (her name has been changed to maintain confidentiality) is a 71-year-old woman from Boston's North End with long-standing cardiac and hepatobiliary disease. Six years ago, breast cancer developed. The tumor was incurable from the time of diagnosis, since it had already spread to bone. The cancer cells tested positive for estrogen and progesterone receptors, and Anna was treated with a series of hormonal agents, which, over the . . .
Erratum: The JAK inhibitor AZD1480 regulates proliferation and immunity in Hodgkin lymphoma
Authors: E Derenzini, M Lemoine, D Buglio, H Katayama, Y Ji, R E Davis, S Sen, A Younes
Journal: Blood Cancer Journal (2014)

Correction to: Blood Cancer Journal (2011) 1, e46; doi:10.1038/bcj.2011.46; published online 2 December 2011 Since the publication of their article, the authors have identified errors in Figures 2 and 5 owing to errors in figures assembly. In Figure 2c, the caspase 9 panel of the HDLM2 cell line andL-428 cell line are inadvertently duplicated.
Cerebral percutaneous transluminal angioplasty in second year of trials
Authors: M. F. Goldsmith
Journal: JAMA (1992)

A TECHNIQUE for treating cerebrovascular atherosclerosis that usually takes at most 1 hour to perform and costs about one third the price of conventional surgery is in its second year of clinical trials and looks "very promising," according to an investigator who spoke at the Second World Congress of Stroke, held in Washington, DC. Randall T. Higashida, MD, associate professor of radiology and neurological surgery, Department of Radiology, University of California, San Francisco (UCSF), Medical Center, says the technique, called cerebral percutaneous transluminal angioplasty, has been used successfully in 127 patients during the past year and has had a complication rate of 6%. The patients ranged from 35 to 80 years of age; two thirds were women and one third men. All were symptomatic, having suffered transient ischemic attacks or stroke, and had high-grade stenosis of greater than 70%. None was considered a good candidate for carotid endarterectomy. The reported
A clinicopathological study of mucosal involvement in linear IgA disease
Authors: S.E. Lelly, F. Wojnarowska, P.A. Frith, A.J. Bron, R.P. Millard, M.M. Black
Journal: British Journal of Dermatology (1987)

The chronic blistering dermatosis, linear IgA disease (LAD), is characterized by subepidermal bullae and linear deposits of IgA in the basement membrane zone (BMZ) of skin. Circulating anti‐BMZ antibodies are infrequently found. The immunogiobulin deposition is considered tobe pathogenetically significant. To investigate the clinicopathological correlation we studied 10 patients with LAD. All were evaluated clinically for evidence of mucosal involvement and immunopathologically for immunoglobulin deposition in skin, oral mucosa and conjunctiva. In addition, normal skin, oral mucosa (intact and chemically separated by incubation with IM NaCl) and conjunctiva were used as substrates in an indirect immunofluorescent technique (IIF) to detect circulating anti‐BMZ antibodies in patients'sera. All 10 patients had clinical evidence of oral involvement and all had linear deposits of IgA in oral mucosa. In one patient, oral mucosa gave a positive result when used as substrate for IIF. Six patients had clinical evidence of ocular involvement but none (of seven examined by conjunctival biopsy) had linear IgA deposits in conjunctiva. Five sera were positive for circulating IgA using conjunctiva as substrate, including one patient with no clinical evidence of ocular disease. This study demonstrates that clinical or immunological assessment alone is unreliable in the evaluation of mucosal disease in LAD. In addition, we have shown that conjunctiva provides the most sensitive substrate for the detection of circulating IgA by IIF.
JAMA Internal Medicine
Authors: Phil Fontanarosa, Annette Flanagin, Brenda Gregoline, Lauren Fischer, John Mcfadden, Karen Boyd, Gabriel Dietz, Rochelle Lodder, Sam Wilder, Diane Cannon, Connie Manno, Fred Marshall, Catherine Copyreaders, Stephanie Alden, Jan Beckmeyer, Mary Clavey, Paula Coerver-Connolly, Laura Glitman, Kenneth King, Donna Lane, Caroline Thordsen, Wanda Assistant, Larry Bryant, Monica Mungle, Elaine Williams, Kathryn Brokke, Fanny Brown, Paul Frank, Lenette Gardner-Gullens, Peter Kim, Rachell Lozano, Michaela Mark, Elizabeth Scientifi, Michael Berkwits, Michelle Kurzynski, Eric Butkus, Will English, Mustafa Ishaq, Daniel Morrow, Reuben Rios, Ronna Henry, Joshua Bird, Karen Bucher, Samantha Welker, David Song, Deputy Livingston, Thomas Cole, Marla Hall, Deanna Willis, Yolanda Davis, Joseph Thornton, Preeti Malani, Deanna Bellandi, Jim Periodical, Thomas Easley, Brian Shields, Monica Smith, Jeff Ery, J Bonistalli, Kathy Russell, Mirna Monal, Stacey Mchugh, Tim Melroy, Marketing Thornbury, Tricia Castellano Classifi, Thalia Moss, Mike Harvey, Susan Henning, Saskia Bolore, Gretchen Linder, Brian Mccartney, David Baum, Rebecca Haas, Christine Hearne, Natasha Nekola, Ron Marketing, Paul Gee, Matt Herron, Elizabeth Solaro, Geoff Rey, Rick Bell, Lindsay Dawson, Craig Mccaff Rey, Michael Mcgraw, Romando Rossini, Stacy Staff, Millette Jackson-Bates, Karen Adams-Taylor, Karl Elvin, Jaye Mize, Sean O'donnell, Sue Managers, David Antos, Chris Borden, Debbie Camp, Lydia Cruz, Scott Curl, Diane Darnell, Colleen Kelly, Chris Meyer, Annemarie Neff, J Neff, Sean Ohlson, Phil O'leary, Bill Pedone, Susan Price, Denise Steinhauser, Joe Advertising, Production Services, Kim Boler, Rhonda Brown, Daniel Degroot, Jordynn Farrar, Euwanaha Joiner-Smith, Cindy Rendlen, Ellen Yoshihara, Circulation Services, Julie Burton, Dexter Golden, Erin Hinchcliff, Noemi Rivera, Geneine Van, Someren Composition, New Media, Gail Barrett, Regina Brownlee, Amanda Camino, Brenda Chandler-Grayer, Emily Dunn, Amy Evers, Teri Hutchison, Mary Kuranda, Joshua Lampinen, Nathan Mitre, Patricia Panek, La Son, Diggs Sledge, George Thomson Graphics, Joe Amft, Maria Duda, Fred Furtner, Carolyn Hall, Maria Kowalkowski, Proofreading Carol, Joy Farrell, Daniel James, Judith Literskis, Teresa Omiotek, Michael Ryder, James Madara, Bernard Hengesbaugh, Kate Denevan, San Francisco, Zachary Goldberger, Nora Goldschlager, Elsayed Soliman, Carolina Cme, Jeff Rey Tabas, Fiona Clement, Rebecca Larson, Howard Bauchner, Rita Redberg, Deborah Grady, Rosemary Gibson, Shannon Brownlee, Tanner Caverly, Ann Arbor, Brandon Combs, Christopher Moriates, Neel Shah, Robert Steinbrook, New Haven, James Colbert, David Brown, St Louis, Lara Goitein, Santa Fe, New Mexico, Chi-Yuan Hsu, Grace Lin, Mary Mcdermott, C Noel, Bairey Merz, Los Angeles, Samia California, Judith Mora, Kathryn Prochaska, Mary Rexrode, New Tinetti, Nicolas Rodondi, Iona Heath, Mitchell Katz, Patrick California, John Boscardin, John Neuhaus, Kenneth Covinsky, Joseph Ross, Blake Charlton, Anna Parks, Adam Schoenfeld, Rachel Stern, Charlotte Dudley
Journal: JAMA Internal Medicine (2015)
Short-term effects of protein intake, blood pressure, and antihypertensive therapy on glomerular filtration rate in the Modification of Diet in Renal Disease Study.
Journal: Journal of the American Society of Nephrology (1996)

Log in or Register Subscribe to journalSubscribe Get new issue alertsGet alerts Enter your Email address: Wolters Kluwer Health may email you for journal alerts and information, but is committed to maintaining your privacy and will not share your personal information without your express consent. For more information, please refer to our Privacy Policy. Subscribe to eTOC Secondary Logo Journal Logo All Articles Images Videos Podcasts Blogs Advanced Search Toggle navigation Subscribe Register Login Articles Current IssuePublished Ahead of Print Subject CollectionsPodcastsArchives Authors Submit to JASNInformation for Authors Journal Info About JASNEditorial TeamEditorial FellowsEditorial Fellowship ApplicationJASN ImpactJASN Recognizes More AlertsAdvertisingSubscriptionsReprints All Articles Images Videos Podcasts Blogs Advanced Search
New Kinetic Test for Stereopsis
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
LIFE OF A PHYSICIAN, FAITHFULLY RECORDED
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cost containment in Oregon: as simple as A x B?
Authors: M. L. Goris
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Editorial Board
Authors: Andrew Schachat, Henry Jampel, Ike Ahmed, Douglas Anderson, F Miami, Aung Tin, James Brandt Sacramento, Wiley Chambers, I Washington, Susan Day, San Francisco, William Freeman, La Jolla, David Friedman Baltimore, Glenn Durham, Yoshiaki Kitazawa, Ronald Madison, Richard Alan, Lewis Houston, Maureen Maguire Philadelphia, Steven Mccormick, New York, Joel Mindel, Arthur Mueller, David Musch, Ann Arbor, Steven Charlottesville, Joan O'brien, Denis O', Day Nashville, Peter Boston, Refractive Matters, Roger Steinert Irvine, Richard Stone Philadelphia, Alan Sugar, M Rohit Varma, Thomas Weingeist Iowa, Richard London, Veronica Managing, Lynn Logan, Patricia Previll, Richard Zorab Vp, Ophthalmic Knowledge, Hal Straus, Thomas Los, Debra Shetlar
Journal: Ophthalmology (2009)
Acute lymphoblastic leukemia
Authors: Martin Schrappe
Journal: HemaSphere (2018)

CAU and UKSH Kiel, Germany This is an open access Abstract Book distributed under the Attribution-NonCommercial-NoDerivs (CCBY-NC-ND), which allows third parties to download the abstracts and share them with others as long as they credit the author and the abstract book, but they cannot change the content in any way or use them commercially. http://creativecommons.org/licenses/by-nc-nd/4.0
Detection of biliary tract disease at operation.
Journal: BMJ (1973)

on their first screening later developed chronic simple glaucoma.This is further evidence against the view that lowered outflow, raised tension, disc cupping, and finally field loss is the sequence of events in the development of this disease.It would seem that the majority of patients with glaucoma develop raised tension followed by cupping; some develop cupping before raised tension; and another minority develop both at the same time.It is difficult to avoid the conclusion that a common factor underlies both cupping and ocular hypertension, probably operating at different loci but not necessarily simultaneously or in a set order.8
Chemicals and Cancer in Humans: First Evidence in Experimental Animals
Authors: James Huff
Journal: Environmental Health Perspectives (1993)

Certain human diseases have been traced to exposure to environmental and occupational chemicals. In many instances the first evidence of potential adverse effects came from experimental studies and were subsequently discovered in humans. Associations of human cancers, as a diverse group of diseases, and chemicals have been made since the middle 1700s. Since then, nearly 100 chemicals, mixtures of chemicals, or exposure circumstances are now recognized as being or strongly implicated as being carcinogenic to humans. Of the less than 1000 agents evaluated adequately for carcinogenicity in laboratory animals, a varying spectrum of data from studies on humans are available for only about 20-25%. So far, more than 60 agents are linked unequivocally as causing cancer in humans, and another 50 or so are strongly suspected of being carcinogenic to humans. Not all of these have been or can be evaluated in animals because some are industrial processes or "occupations," some are environmental and cultural risk factors, and some are mixtures of agents. For those that can be studied experimentally, the qualitative concordance between humans and animals approaches unity, and in every case there is at least one common organ site of cancer in both species. The evidence of carcinogenicity in experimental animals preceded that observed in humans for nearly 30 agents and is the subject of this paper.
The EWYM Syndrome—Asymptomatic Gonorrhea
Authors: Richard Gleckman
Journal: JAMA (1975)

WHEN I walked into my office waiting room, I noticed a young man sitting alone in a corner. I had never seen him before; my receptionist informed me that an appointment had been arranged for him by a young woman who had telephoned. In requesting the office visit, she had only stated that the young man should be "checked out." In the privacy of the examining room, the young man grinned sheepishly and told me that he lived with a woman college student who had recently required treatment for "hot tubes." It was this event that precipitated the request for a medical evaluation. The woman denied having had sexual relationships with other men during the last year, and my patient denied having been sick in any way, and certainly didn't have "any drip." Since the relationship was becoming strained due to the question of "infidelity," it appeared necessary to go
ECG Challenge: July 16, 2013
Authors: Philip Podrid
Journal: Circulation (2013)

A 69-year-old man with a known history of coronary artery disease and a previous myocardial infarction is seen for a routine physical examination.He denies all symptoms.His examination is unremarkable, but an irregular pulse is felt with episodes of pauses noted.What is the diagnosis?To submit your diagnosis, go to http://circ.ahajournals.org/
Effects of uninephrectomy on electrical properties of the cortical collecting duct from rabbit remnant kidneys.
Authors: S Ebata, S Muto, Y Asano
Journal: Journal of Clinical Investigation (1992)

Microelectrode techniques were used to determine the Na+ and K+ transport properties of the collecting duct cell in the isolated cortical collecting duct (CCD) from rabbits 14 d after uninephrectomy (UNX); results were compared with those from sham-operated rabbits (control). UNX had no effects on plasma aldosterone levels. The CCDs from UNX rabbits exhibited structural hypertrophy. The lumen negative transepithelial voltage and the basolateral membrane voltage (VB) were elevated in the UNX group. Although the transepithelial conductance (GT) and the fractional apical membrane resistance (fRA) were not different between the two groups, the conductances of the apical and the basolateral membranes were increased, and the tight junction conductance was decreased in the UNX group. The amiloride-sensitive changes in apical membrane voltage (VA), fRA, and GT were greater in the UNX group. The changes in VA upon raising the perfusate K+ concentration and the changes in VA and GT upon addition of Ba2+ to the perfusate were elevated in the UNX group. Upon raising K+ in the bath, a large depolarization of VB was observed in the UNX group. Lowering the bath Cl- resulted in a small depolarization of VB in the UNX group. Addition of Ba2+ to the bath in the UNX group caused the VB to hyperpolarize in parallel with decreases in GT and fRA whereas in the control group it had no effect on VB. Addition of ouabain to the bath resulted in a large depolarization of VB in the UNX group. We conclude that (a) UNX stimulates conductances of Na+ and K+ in the apical membrane, active Na(+)-K+ pump activity, and K+ conductance in the basolateral membrane, independently of plasma aldosterone; (b) The basolateral membrane in the tubules of UNX rabbits is more selective to K+; and (c) the hyperpolarization of VB upon UNX may increase passive K+ entry into the cell across the basolateral membrane.
Asklepios
Authors: Perry A. Ball
Journal: Annals of Internal Medicine (1996)

Letters1 August 1996AsklepiosPerry A. Ball, MDPerry A. Ball, MDDartmouth-Hitchcock Medical Center, Lebanon, NH 03756Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-3-199608010-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Bailey's review of the myth of Asklepios [1] and the importance of compassion is timely, given the increasing expectations and uncertainties that contemporary physicians face. An irony of modern medicine and its symbols is that the staff of Asklepios, which is entwined by a single serpent, has been replaced by the caduceus, entwined by double serpents. The latter is the symbol of Hermes, the patron god of thieves.REFERENCE1. Bailey JE. Asklepios: ancient hero of medical caring. Ann Intern Med. 1996; 124:257-63. Google Scholar Author, Article, and Disclosure InformationAffiliations: Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1996Volume 125, Issue 3Page: 254KeywordsMotivation Issue Published: 1 August 1996 CopyrightCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Classification of burn-care facilities in the United States
Authors: I. Feller
Journal: JAMA (1971)

The concept of specialized care facilities for the burned patient is relatively new. The first "burn units" were established in 1947 at the Medical College of Virginia, and at the Army Surgical Research Unit in San Antonio, Tex. These units were organized to provide, within their walls, almost all of the resources required for these severely injured patients. Additional units were established in the next two decades. In 1969, a survey of the short-term general and children's hospitals in the United States was completed, to determine the availability of facilities for the care of the burned patients. Only 32 such facilities could be identified. In addition to the hospitals that provide special facilities for burned patients, 46 others are identified with improved care. These facilities and special programs are not alike, and a classification of them is provided to differentiate the levels of care provided. Of the 6,062 hospitals initially
KCC2 regulates actin dynamics in dendritic spines via interaction with β-PIX
Authors: Olaya Llano, Sergey Smirnov, Shetal Soni, Andrey Golubtsov, Isabelle Guillemin, Pirta Hotulainen, Igor Medina, Hans Gerd Nothwang, Claudio Rivera, Anastasia Ludwig
Journal: The Journal of Experimental Medicine (2015)
Fibrosis and disease progression in hepatitis C
Authors: Patrick Marcellin, Tarik Asselah, Nathalie Boyer
Journal: Hepatology (2002)

The progression of fibrosis in chronic hepatitis C determines the ultimate prognosis and thus the need and urgency of therapy. Fibrogenesis is a complex dynamic process, which is mediated by necroinflammation and activation of stellate cells. The liver biopsy remains the gold standard to assess fibrosis. Scoring systems allow a semiquantitative assessment and are useful for cross-sectional and cohort studies and in treatment trials. The rate at which fibrosis progresses varies markedly between patients. The major factors known to be associated with fibrosis progression are older age at infection, male gender, and excessive alcohol consumption. Viral load and genotype do not seem to influence significantly the progression rate. Progression of fibrosis is more rapid in immunocompromised patients. Hepatic steatosis, obesity, and diabetes may also contribute to more rapid progression of fibrosis. There are no tests that reliably predict the rate of progression of fibrosis in an individual patient. High serum alanine aminotransferase (ALT) levels are associated with a higher risk of fibrosis progression, and worsening of fibrosis is uncommon in patients with persistently normal serum aminotransferase levels. Serum markers for fibrosis are not reliable and need to be improved and validated. Liver biopsy provides the most accurate information on the stage of fibrosis and grade of necroinflammation, both of which have prognostic significance. Repeating the liver biopsy, 3 to 5 years after an initial biopsy is the most accurate means of assessing the progression of fibrosis. (Hepatology 2002;36:S47-S56).