tbuckley/cabot-search huggingface dataset:
Transferrin receptor-independent uptake of differic transferrin by human hepatoma cells with antisense inhibition of receptor expression
Authors: D Trinder, O Zak, P Aisen
Journal: Hepatology (1996)

The hepatic uptake of transferrin–bound iron by a nontransferrin receptor (NTR)–mediated process was investigated using the human hepatoma cell line HuH7. Because HuH7 cells also acquire iron from transferrin by a receptor (TR)–mediated process, TR expression was inhibited by transfecting the cells with a plasmid containing human TR complementary DNA in antisense orientation relative to a human cytomegalovirus promoter/enhancer element. Cell clones were obtained that expressed a 50% to 60% reduction in cell surface TR, leading to a corresponding decrease in transferrin and iron uptake compared with wild–type cells. Uptake of transferrin by a second process was nonsaturable and not inhibited by a 100–fold excess of unlabeled transferrin. The amounts of transferrin taken up by the wild–type and antisense cells by this process were similar, showing that it did not involve TR. The proteolytic enzyme Pronase reduced the uptake of transferrin, suggesting that the NTR–mediated process entailed the nonsaturable binding of transferrin to plasma membrane proteins. This process, like the TR–mediated one, involved the internalization and recycling of transferrin, leading to accumulation of iron with time. Iron uptake mediated by NTR process was saturable and displaced by 100–fold excess unlabeled transferrin and reduced by weak bases and metabolic inhibitors. Therefore, the NTR–mediated process entailed transferrin adsorption to membrane–bound proteins, internalization, and release of iron from transferrin by a pH–dependent step followed by the intracellular transport of iron into ferritin and heme by a saturable carrier–mediated mechanism.
IA. Medical Schools in the United States (cont)
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Acetaminophen misconceptions
Authors: Barry H. Rumack
Journal: Hepatology (2004)

Examination of the pharmacokinetics of acetaminophen can decrease misconceptions involved in clinical evaluation. Enzyme patterns and acetaminophen levels must be related to time and known metabolic phenomena. A careful look at ethanol and nutrition, especially fasting demonstrates that therapeutic doses of acetaminophen do not place patients at a greater risk in either of these instances. An overdose of acetaminophen in a chronic alcohol abuser may result in more severe hepatotoxicity than in the nonalcoholic. CYP2E1 and glutathione must be evaluated simultaneously rather than in isolation. Glucuronidation capacity in humans is not a factor except in massively overdosed patients. (Hepatology 2004;40:10-15.)
Sports-Related Recurrent Brain Injuries— United States
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
OS11.5 ACT IV: An international, double-blind, phase 3 trial of rindopepimut in newly diagnosed, EGFRvIII-expressing glioblastoma
Authors: M. Weller, N. A. Butowski, D. D. Tran, L. D. Recht, D. M. O’Rourke, G. Finocchiaro, J. R. Perry, W. Wick, R. Stupp, J. H. Sampson
Journal: Neuro-Oncology (2017)

Background: The EGFR deletion mutation, EGFRvIII, is expressed in ~30% of glioblastomas (GBM). The EGFRvIII-targeted vaccine rindopepimut consists of EGFRvIII peptide conjugated to keyhole limpet hemocyanin (KLH). A survival benefit was observed in a randomized phase 2 trial of recurrent GBM (ReACT; n=73). In three phase 2 studies of 105 total patients with newly diagnosed, EGFRvIII+ GBM and minimal residual disease (MRD), the median overall survival (mOS) was 20–22 months, as compared to ~16 months for two matched contemporary datasets (n=16, n=29). Methods: Patients with newly diagnosed, resected, EGFRvIII+ GBM were, after standard chemoradiation, stratified by RPA class, MGMT promoter methylation, and geographic region, and randomized (1:1) to double-blind rindopepimut or control (KLH) concurrent with standard maintenance temozolomide. Primary endpoint is OS for MRD patients (enhancing tumor <2 cm2 post-chemoradiation by central review) aiming to detect hazard ratio (HR) ≤0.71 with 80% power and alpha=0.05 (log-rank test). Interim analyses were preplanned at 50% and 75% of events. Secondary analyses included patients with ≥2 cm2 of residual tumor (non-MRD). Results: 745 patients (405 MRD) were enrolled at 165 centers. The study was terminated for futility after the 2nd interim analysis (MRD OS HR=0.99). At final analysis, mOS for rindopepimut vs. control was 20.1 vs. 20.0 (HR=1.01; p=0.93) in the MRD cohort, and 14.8 vs. 14.1 (HR=0.79; p=0.066) with 2-year OS 30% vs. 19% in the non-MRD cohort. There were no substantial differences in progression-free survival. Rindopepimut was well tolerated (chief toxicity: injection site reaction) with robust anti-EGFRvIII immune response. Conclusions: The study failed to demonstrate a survival benefit for patients treated with rindopepimut and standard chemotherapy. Rindopepimut OS is comparable to prior studies, however, patients in the control arm fared better than historical controls. A trend for long-term survival benefit in non-MRD patients suggests a preferential effect in bulkier disease.
ENGLISH DIET
Journal: JAMA (1961)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
<i>Erratum</i>: Vol. 65, No. SS-12
Journal: MMWR Morbidity and Mortality Weekly Report (2020)

In the Surveillance Summary "Abortion Surveillance -United States, 2013," data on the number of known previous induced abortions for women having abortions in this reporting year were erroneously included for New York City.These estimates did not meet reporting standards and should have been excluded from this report.When corrected, among women with abortions in the reporting year, the proportion with no previous induced abortions increased, and the proportion with one or more previous induced abortions decreased.In addition, Nebraska was erroneously excluded as a reporting area for the relevant years of comparison for estimates on reported abortions, by known number of previous induced abortions.Data have been updated to include Nebraska.On page 9, the last paragraph of the first column should have read "Data from the 38 areas that reported the number of previous abortions for women who obtained abortions in 2013 indicate that the majority (57.7%) had no previous abortions, 35.5% had one to two previous abortions, and 6.8% had three or more previous abortions (Table 17).Among the 30 reporting areas § § § § that provided data for the relevant years of comparison (2004 to 2013, 2004 versus 2008, 2009 versus 2013, and 2012 versus 2013), the percentage of women who had zero or one to two previous abortions did not change appreciably over time: 57.8%, 58.2%, and 58.1% had zero previous abortions in 2004, 2012, and 2013, respectively, and 35.9%, 34.9%, and 35.0% had one to two previous abortions in 2004, 2012, and 2013, respectively.In contrast, among these 30 areas, the percentage of women who had three or more previous abortions increased from 2004 to 2013 but did not change appreciably from 2012 to 2013: 6.3% had three or more previous abortions in 2004, as compared with 6.8% in 2012 and 6.8% in 2013."New York City should have been included, and Nebraska should not have been included in the § § § § footnote, which lists reporting areas that were not included in these estimates.In Table 17, the line for New York City should be deleted.For the total line, the numbers and percentages should have read 213,976 (57.7), 92,992 (25.1), 38,551 (10.4), 25,291 (6.8), 370,810 (98.7).
Equitable selection of kidney recipients
Authors: H. P. Young
Journal: JAMA (1989)

<h3>To the Editor. —</h3> The increased number and success of kidney transplantations has focused national attention on the equity of the system by which recipients are selected. In an attempt to address the equity issue, the United Network for Organ Sharing recently adopted the point system of Starzl et al<sup>1</sup>for selecting cadaver kidney recipients. Several authors have taken issue with the way in which the factors in the formula by Starzl et al are weighted.<sup>2,3</sup>We draw attention to another problem with the formula that seems to have escaped notice: as patients at the head of the line receive transplants, the order among the remaining patients may shift. This bizarre result calls the equity of the method into question. The allocation formula described by Starzl et al assigns point values to each patient based on waiting time and other factors. These are combined into a "priority index"
Results of an educational tool for residents and referring physicians on palliative radiation for bone metastases.
Authors: Nina Desai, Malcolm David Mattes, Eric Bonar, Grant Robertson, Candice Aitken Johnstone
Journal: Journal of Clinical Oncology (2018)

e22167 Background: Palliative radiation therapy (RT) for painful bone metastases is underutilized in the United States (US), perhaps due to inappropriate use of multi-fraction (MF) regimens over more convenient, less costly, and equally effective single fraction (SF) regimens. Practice patterns may change with improved knowledge of radiation oncology residents (ROR) and non-radiation oncology physicians who refer patients for palliative RT. The aim of this study was to provide evidence-based educational content to these groups, and assess knowledge and views before and after. Methods: In April-June 2017, an electronic educational tool was sent to medical oncology and palliative care physicians, and ROR in the US. Multiple choice questions assessed knowledge, and were followed by evidence supporting the correct answer. Likert and sliding scales gaged tool impact. Chi-square and Mann-Whitney tests compared groups and pre/post-test responses. Results: Responses were obtained from 109 (2%) referring physicians (RP) and 135 (21%) ROR. ROR had higher scores than RP for 8 of 9 objective questions. RP were less likely to know that SF and MF are equivalent in terms of pain response (64 v. 91%, p < .01) and subsequent analgesic use (86 v. 95%, p = .02), or that SF is associated with a higher retreatment rate (27 v. 93%, p < .01). ROR were less likely to know that SF and MF are equivalent for patients with a high likelihood of long term survival (25 v. 56%, p < .01). After viewing the content, ROR felt more knowledgeable [mdn 3 (IQR 3-4) v. 4 (IQR 3-4), p < .01], and RP felt more empowered [mdn 3 (IQR 2-4) v. 4 (IQR 3-4), p < .01]. RP found the survey more helpful, and knew less of the data prior [mdn 50 (IQR 25-75%) v. 80% (IQR 66.3-90%), p < .01]. Despite knowing the data, ROR preferred SF less than RP at completion (67 v. 85%, p < .01). Conclusions: This study demonstrates a need for educational content for multidisciplinary providers on appropriate palliation of bone metastases. Despite ample knowledge, the bias of practicing radiation oncologists for MF is being passed onto residents. Greater knowledge may translate into more effective referral patterns and patient advocacy by RP, and potentially improve utilization of palliative RT in the US.
Postoperative Hyponatremia
Authors: J. Carlos Ayus
Journal: Annals of Internal Medicine (1997)

Letters15 June 1997Postoperative HyponatremiaJ. Carlos Ayus, MD and Allen I. Arieff, MDJ. Carlos Ayus, MDBaylor College of Medicine, Houston, TX 77030University of California Medical Center, San Francisco, CA 94122Search for more papers by this author and Allen I. Arieff, MDBaylor College of Medicine, Houston, TX 77030University of California Medical Center, San Francisco, CA 94122Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-126-12-199706150-00030 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We read with interest the study by Steele and colleagues [1] suggesting that near-isotonic fluid infusion could decrease the plasma sodium level in postoperative patients. They have thus confirmed that the phenomenon in which volume expansion in persons with elevated plasma antidiuretic hormone levels results in a substantial quantity of infused NaCl excreted in the urine [2] also applies to persons who have just had surgery. However, these findings should not suggest that infusion of isotonic (154 mmol of NaCl per L) can lead to postoperative hyponatremic encephalopathy. Among 158 postoperative patients with hyponatremic encephalopathy studied at ...References1. Steele A, Gowrishankar M, Abrahamson S, Mazer CD, Feldman RD, Halperin ML. Postoperative hyponatremia despite near-isotonic saline infusion: a phenomenon of desalination. Ann Intern Med. 1997; 126:20-5. Google Scholar2. Nolph KD, Schrier RW. Sodium, potassium, and water metabolism in the syndrome of inappropriate antidiuresis. Annu Rev Med. 1980; 31:315-27. Google Scholar3. Ayus JC, Arieff AI. Brain damage and postoperative hyponatremia: role of gender. Neurology. 1996; 46:323-8. Google Scholar4. Ayus JC, Wheeler JM, Arieff AI. Postoperative hyponatremic encephalopathy in menstruant women. Ann Intern Med. 1992; 117:891-7. Google Scholar5. Ayus JC, Arieff AI. Glycine-induced hypoosmolar hyponatremia. Arch Intern Med. 1997; 157:223-6. Google Scholar Author, Article, and Disclosure InformationAffiliations: Baylor College of Medicine, Houston, TX 77030University of California Medical Center, San Francisco, CA 94122 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByMajor Complications, Mortality, and Resource Utilization After Open Abdominal SurgeryFluid is a Drug that can be Overdosed in the ICUHyponatriämieAvoiding common problems associated with intravenous fluid therapyPoint-of-Care Decision Making, Adaptive Systems and Outcomes Optimization (and the National Directives for Improved Healthcare) 15 June 1997Volume 126, Issue 12Page: 1005KeywordsBlood plasmaBrain diseasesHysterectomyIsotonicityLactatesResearch laboratoriesSodiumSodium chlorideSurgeryUrine Issue Published: 15 June 1997 CopyrightCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Brain Lipids and Lipoproteins, and the Leucodystrophies. Proceedings of the Neurochemistry Symposium, VII International Congress of Neurology, Rome, 1961. Organized by the Problem Commission of Neurochemistry of the World Federation of Neurology.
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
<TITLE>Treating Depression With Electroconvulsive Therapy</TITLE>
Journal: JAMA (2001)

a public service of JAMA.The information and recommendations appearing on this page are appropriate in most instances, but they are not a substitute for medical diagnosis.For specific information concerning your personal medical condition, JAMA and the AMA suggest that you consult your physician.This page may be reproduced noncommercially by physicians and other health care professionals to share with patients.Any other reproduction is subject to AMA approval.
"FURLOUGH" PSYCHOSIS
Authors: GEORGE F. SUTHERLAND, MILFORD E. BARNES
Journal: American Journal of Psychiatry (1946)

Twelve cases were observed showing an acute schizophrenic reaction, seemingly precipitated by the sudden emotional readjustments necessitated by leave or furlough. The onset of the symptoms occurred abruptly a few days after these apparently well adjusted individuals had returned home. The clinical symptoms, however, were not sufficiently clear-cut to include them in a single diagnostic category. The 4 typical case histories cited indicate that the episode was provoked by the sudden release from military authority upon which the individual had become emotionally dependent.
Rural Health Directory
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
More Snakes
Authors: Gabriel I. Barbash
Journal: JAMA (1985)

<h3>To the Editor.—</h3> In a recent issue ofThe Journal, Dr Rakel<sup>1</sup>discussed the origins of both the twin-snake caduceus and the single-snake staff of Aesculapius as symbols of medicine. In his discussion, Dr Rakel looked back to 800 BC and pointed out the roots of the snake and staff motif in Greek mythology. We would like to revive appreciation of another source for the association between the snake and the staff and the healing arts that dates from a much earlier period. Although keeping records was not characteristic of that period, we are lucky to benefit from one scene captured in the Old Testament (Numbers 21:5-19): And the people spake against God and against Moses.... Then God let the poisonous serpents loose against the people, and they bit the people and many people of Israel died. Then the people came to Moses and said; We have sinned, for