tbuckley/cabot-search huggingface dataset:
Läkartidningen, Stockholm
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Understanding rosacea
Authors: F.C. Powell
Journal: British Journal of Dermatology (2015)

ORIGINAL ARTICLE, p 651 The comprehensive systematic review of 106 randomized controlled trials for rosacea involving 13 631 participants by van Zuuren and Fedorowicz1 in this issue of the BJD provides valuable evidence as to the effectiveness of established and new treatments for patients with rosacea. Rosacea is a poorly understood yet common facial skin disorder often associated with ocular symptoms. The term ‘rosacea’ is commonly used by dermatologists to describe patients who have a constellation of symptoms and signs ranging from frequent flushing to hypertrophic nasal enlargement. While the classification of rosacea into subtypes2 helped clinicians to develop a strategy of disease management for their patients,3 the spectrum of clinical features included under the title ‘rosacea’ made it likely that more than one pathogenic pathway would be operative in this disorder. This is reflected in the wide variety of therapies used for rosacea ranging from surgery (for rhinophyma) to topical and systemic antibiotics [for papulopustular rosacea (PPR)].
Dissolution of human insulin
Authors: D. S. Schade
Journal: JAMA (1987)

Intermediate- (isophane or NPH) and long-acting (ultralente) insulins are injected every day by millions of diabetic patients. Surprisingly, little is known about the actual dissolution of the insulin crystal in subcutaneous tissue. However, it is known that the appearance of the free insulin into the circulation is erratic, resulting in as much as a 100% day-to-day variation in blood insulin levels from the same quantity of injected NPH insulin.<sup>1</sup>In an attempt to understand the initial steps in the dissolution of the insulin crystal, we perfused human NPH insulin crystals (recombinant DNA derived, Eli Lilly &amp; Co, Indianapolis) with a physiological solution for four hours at a flow rate of 50 mL/h at 27°C. The solution contained sodium, 142 mmol/L (142 mEq/L); chloride, 121 mmol/L (121 mEq/L); bicarbonate, 25 mmol/L (25 mEq/L); and potassium, 4 mmol/L (4 mEq/L), at a pH of 7.4. The insulin crystals were perfused on a
Medical Advertising.
Journal: JAMA (1883)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 2553: Integration of genomic studies and the patient-derived xenograft model in nasopharyngeal carcinoma precision medicine research
Authors: Cheng-Lung Hsu, Hsin-Pai Li
Journal: Cancer Research (2019)

Abstract Patient-derived xenograft (PDX) tumor model has become a new approach to identify druggable tumor mutations, and to screen and evaluate personalized anti-cancer drugs. Here, we established five nasopharyngeal carcinoma (NPC) PDXs in mouse model and performed whole-exome sequencing (WES) and copy number variations (CNVs) analyses. Relatively high incident rate of CNV aberration in cell cycle pathway was detected. Among these five NPC-PDXs, three had cyclin D1 (CCND1) amplification while four had cyclin-dependent kinase inhibitor CDKN2A deletion. Selected inhibitors were tested for their anti-tumor effects in two NPC-PDX mouse models. Palbociclib, a cyclin-dependent kinase inhibitor, revealed efficient anti-tumor effects by inducing G1 arrest in the PDX tumor according to RNA sequencing. In this study, cyclin D1 overexpression was also observed in &amp;gt;90% clinical metastatic NPC tumors (87/91) and was associated with poor outcomes. One NPC patient with liver metastatic who was prescribed with Palbociclib had stable disease and a drop in Epstein Barr virus (EBV) DNA titer. CNV analysis disclosed that plasma CCND1/CDKN2A ratio is correlated with EBV DNA load in NPC patients’ plasma and could serve as a screening test to select potential CDK4/6 inhibitors treatment candidates. Taken together, our findings indicate that integrated information from sequencing-based genomic studies and tumor transcriptomes before and after drug treatment in NPC-PDX models provide novel guidelines for personalized precision treatments. Citation Format: Cheng-Lung Hsu, Hsin-Pai Li. Integration of genomic studies and the patient-derived xenograft model in nasopharyngeal carcinoma precision medicine research [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2553.
Pathological Contributions to Medical Jurisprudce
Authors: W. B. Mushet
Journal: BMJ (1859)

pno.5, 18sm"] OH.IE" OOMMUNICAfION8 [Bamsa MUDnAL JoUMtAL.ing in bed, and tenderness over upper dorsal vertebra, in.,resed by pressre.The bowels were constipated.Calomel and oolocynth pills, nitro-hydroebloric acid, good diet and rest, were successful in affording relief.
Hepatic and Renal Studies with Iron-59 EDTA in Patients With and Without Liver or Kidney Disease
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Falciparum malaria in seamen
Authors: W. A. Krotoski
Journal: JAMA (1978)

Three cases of<i>Plasmodium falciparum</i>malaria in seamen, all acquired while working off tropical West Africa, and all in patients coming in for treatment at a New Orleans hospital during one six-week period, are described in the context of the importance of considering recent travel history for arrival at the correct diagnosis and treatment. Two of the three patients whose cases are reported had taken some form of malarial chemoprophylaxis during their voyage. (<i>JAMA</i>239:2778-2779, 1978)
c-MET receptor-targeted fluorescence on the road to image-guided surgery in penile squamous cell carcinoma patients
Authors: H.M. De Vries, E. Bekers, M.N. Van Oosterom, M.B. Karakullukcu, H.G. Van Der Poel, F.W.B. Van Leeuwen, T. Buckle, O.R. Brouwer
Journal: European Urology (2021)
PERIODIC EXAMINATIONS AND MEDICAL PRESCIENCE.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 15178: The Clinical Characteristics of Patients With Ischemia-oriented or Coronary Computed Tomography Angiography-oriented Percutaneous Coronary Intervention, a Report From the Multicenter Registry
Authors: Jun Fujita, Shun Kohsaka, Ikuko Ueda, Taku Inohara, Yuichiro Maekawa, Akio Kawamura, Hideaki Kanazawa, Kentaro Hayashida, Ryota Tabei, Shugo Tohyama, Tomohisa Seki, Masahiro Suzuki, Motoaki Sano, Keiichi Fukuda
Journal: Circulation (2015)

Background: Myocardial perfusion scintigraphy (MPS) plays a pivotal role in the evaluation of ischemia. Coronary computed tomography angiography (CTA) is emerging to evaluate anatomical features for stable ischemic heart disease (SIHD). This study aimed to identify the clinical characteristics of ischemia (MPS) or anatomy (CTA)-oriented percutaneous coronary intervention (PCI) patients for SIHD. Methods and Results: Data were analyzed from 4197 SIHD patients undergoing PCI in The Japan Cardiovascular Database (N = 11,258) between September 2008 and April 2013. MPS was used to evaluate 1070 (25.5%) patients. Significant ischemia (SI) was defined as more than 10% ischemic region. CTA was performed in 1433 patients, and patients with ischemia evaluation and unavailable results were excluded. A total of 694 patients (16.5%) were evaluated as CTA group. CTA-oriented PCI patients had milder illness in their background (Table). More than half of patients had multivessel disease (CTA vs non-SI vs SI; 51.6, 66.3, 71.9%). Incomplete revascularization ratio was significantly lower in CTA group (0.6, 2.2, 3.1%, p = 0.003). However, CTA-oriented PCI patients and SI patients had significantly more complications than non-SI patients (6.6, 3.8, 8.2%, p = 0.022), especially post-procedural infarction (2.4, 0.5, 3.0%, p = 0.032) (Figure). Conclusions: Even though CTA-oriented PCI patients had incomplete revascularization less frequently, they experienced more complications. These results indicate that functional assessment is important to predict in-hospital complications, and physicians need to give their attention to CTA-oriented PCI patients as well as SI patients.
AN EXPERIMENT IN SEASICKNESS.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Acute renal failure and maneb (manganous ethylenebis[dithiocarbamate]) exposure
Authors: A. Koizumi
Journal: JAMA (1979)

A 62-year-old man spread maneb on about 200 sq m of garden and subsequently was taken to the emergency clinic with complaints of oliguria, diarrhea, and hoarseness. Based on the clinicobiochemical data, he was found to have acute renal failure; the serum levels of BUN, creatinine, and potassium were 144.3 mg/dL, 14 mg/dL, and 5.8 mEq/L, respectively. The ST segment depression in V<sub>4-6</sub>, reciprocal ST segment elevation in V<sub>1-3</sub>, and inverted T waves in V<sub>5</sub>and V<sub>6</sub>were recorded on ECGs. Both the renal failure and the ECG abnormalities disappeared after hemodialysis. The possibility exists that the maneb caused the acute renal failure. (<i>JAMA</i>242:2583-2585, 1979)
25-year mortality after surgical repair of congenital heart defect in childhood. A population-based cohort study
Authors: C. D. Morris
Journal: JAMA (1991)

<h3>Objective.</h3> —To determine long-term survival and the cause of death after repair of one of eight congenital heart defects in childhood. <h3>Design.</h3> —Cohort study. <h3>Setting.</h3> —General community. <h3>Participants.</h3> —All Oregon residents with one of eight congenital heart defects, which was repaired surgically between 1958 and 1989 when the patient was aged 18 years or younger, including (1) tetralogy of Fallot; (2) isolated ventricular septal defect; (3) isolated atrial septal defect; (4) coarctation of the aorta; (5) aortic valvular stenosis; (6) pulmonary valvular stenosis; (7) transposition of the great arteries; and (8) patent ductus arteriosus. Follow-up of this cohort of 2701 individuals was obtained from 94%. <h3>Main Outcome Measure.</h3> —Mortality from cardiac and noncardiac causes. <h3>Results.</h3> —Age at surgery and operative mortality have decreased significantly over the last 30 years. Late cardiac mortality at 25 years after surgery was 5% for tetralogy of Fallot and isolated ventricular septal defect, 10% for coarctation of the aorta, 17% for aortic stenosis, 5% for pulmonic stenosis, and less than 1% for patent ductus arteriosus; there were no late cardiac deaths after atrial septal defect repair. For transposition, late cardiac mortality was 15% at 15 years after the Mustard operation and was 2% at 10 years after the Senning operation. <h3>Conclusion.</h3> —Surgical repair of most congenital heart defects is associated with lingering cardiac mortality, particularly for aortic stenosis, coarctation, and transposition. (<i>JAMA</i>. 1991;266:3447-3452)
ESGE Newsletter
Journal: Endoscopy (2015)

Combined endobronchial and esophageal endosonography for the diagnosis and staging of lung cancer: European Society of Gastrointestinal Endoscopy (ESGE) Guideline, in cooperation with the European Respiratory Society (ERS) and the European Society of Thoracic Surgeons (ESTS) See pages 545 – 559 in this issue of Endoscopy
LEUKOCYTES IN SCHIZOPHRENIA
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Disinfection and Disinfectants. A Treatise upon the Best Known Disinfectants. Their Use in the Destruction of Disease Germs, with Special Instruction for Their Application in the Commonly Recognized Infectious and Contagious Diseases.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Multicenter study of weekly trastuzumab, paclitaxel, and carboplatin followed by a week of rest every 28 days in patients with HER2+ metastatic breast cancer
Authors: M. Ruiz, J. Salvador, J. Bayo, M. Lomas, A. Moreno, M. Valero, R. Bernabé, D. Vicente, J. Jimenez, A. López-Ladrón
Journal: Journal of Clinical Oncology (2008)

1080 Background: The addition of carboplatin to trastuzumab and paclitaxel improves the efficacy in HER2+ metastatic breast cancer (MBC). We have conducted a multicenter phase II study to investigate the efficacy and safety of this combination given weekly x 3 followed by 1 week of rest. Primary endpoint was objective response rate and secondary endpoints were time to progression, overall survival and to study the toxicity profile of the combination. Methods: Between August 2003 and April 2006, 40 patients with HER2+ MBC (IHC 3+ or FISH+) have been included in the study. Pats received trastuzumab (loading dose of 4 mg/kg/wk and 2 mg/kg/d following wks), paclitaxel (80 mg/m2) and carboplatin (AUC 2) all given weekly x 3 followed by 1 week of rest. Treatment was given until disease progression or unacceptable toxicity. Results: 40 pats had baseline data available. Median age was 54 yrs (range 29–75). 38 (95%) pats received prior adjuvant or neoadjuvant treatment. 11 (27,5%) pats have received one prior CT line for metastatic disease. 87,5% pats had PS 0 or 1 at study entry. Disease sites were liver 16 (40%), bone 12 (30%), lymph nodes 13 (32.5%) and lung 8 (20%). 19 (47.5%) had 2 lesions. 97.5% had measurable disease. 36 pats have been evaluated for response: 11 CR (31%, 95% CI: 15–46%), 11 PR (31%, 15–36%), 9 SD (25%, 9–36%), 5 PD (14%, 2–26%) and 4 NE resulting in an ORR of 61% (95% CI: 45–77%) and tumor growth control rate (RR+SD) of 86% of patients (95% CI: 75–97%). Median TTP was 12.1 mo (95% CI: 8.8–19.9 mo) and median duration of response and OS have not been reached yet. For a time of observation of 35 mo, the OS is 80,6%. 37 patients have received 194 cycles with a median of 5 cycles. Grade 3–4 toxicities/pats were: 3 (7.5%) anaemia, 2 (5%) leucopenia, 8 (20%) neutropenia, 1 (2.5%) febrile neutropenia, 1 (2.5%) trombopenia, 2 (5%) asthenia, 2 (5%) diarrhea, 3 (7.5%) nausea, 2 (5%) vomiting, 3 (7.5%) mucositis. Conclusions: This interim analysis shows an interesting activity with this regimen. One week of rest may be of better convenience for the patient and hospital but also may improve the tolerability profile and efficacy of the combination. Further results would be available for presentation. No significant financial relationships to disclose.
Cross-Sectional Study with Multiple Measurements of Biological Markers for Assessing Stomach Cancer Risks at the Population Level
Authors: Shcoichiro Tsugane, Mitsuhiro Tsuda, Fred Gey, Shaw Watanabe
Journal: Environmental Health Perspectives (1992)

A cross-sectional study to determine correlations between measurable biologic markers and mortality from stomach cancer was performed in various areas of Japan. Blood and urine were collected from randomly selected 40- to 49-year-old men and their spouses in four areas with different rates of mortality from stomach cancer. The samples were analyzed for levels of the micronutrients vitamins A, C, and E, beta-carotene, and lycopene in plasma and for levels of NaCl, nitrate, and N-nitrosamino acids (N-nitrosoproline, N-nitrosothioproline [NTPRO] and N-nitrosomethylthioproline [NMTPRO]) in 24-hr urine. A significant, strong correlation was found between the amount of salt excreted in urine and stomach cancer mortality in both men and women. Although the amounts of nitrate and of the three N-nitrosamino acids in 24-hr urine were not correlated with stomach cancer rates, the low excretion levels of NTPRO and NMTPRO in the lowest risk area for stomach cancer were noteworthy, regardless of the high level of nitrate excretion in the same area. This suggests a lesser degree of endogenous nitrosation in the body. No protective effect of micronutrients was observed in this correlation study; there was, however, a negative correlation between plasma lycopene level and stomach cancer mortality. Salt intake was thus confirmed to play an important role in the development of stomach cancer and is likely to be a rate-regulating factor in Japanese populations. N-Nitrosamino acids and lycopene may also be related to stomach cancer mortality.