tbuckley/cabot-search huggingface dataset:
Civil Defense Agency
Authors: Thomas F. Maher, Helen G. Kearsley
Journal: New England Journal of Medicine (1954)

SIGNIFICANT FACTORS IN THE DEVELOPMENT OF A HOSPITAL DISASTER PLANThe tornado in June, 1953, required the hospitals in the vicinity of Worcester, without warning, to mobilize immediately, giving them an unprecedented opportunity to evaluate the effectiveness of their disaster plans. They successfully mobilized their personnel and facilities to care for thousands of casualties.Successful mobilization of a hospital to combat any sudden disaster can best be accomplished by previous detailed preparation. Disaster preparedness can only be developed and maintained by persistent awareness of the specific problems to be encountered.Every hospital can develop its own comprehensive disaster plan for . . .
The Services
Journal: BMJ (1931)

JOURENAL t be registered in the Medical Register before admission to Part II of the examination.The object of this two years' interval is `to provide opportunity for 'candidates, while passing from the state of pupilage to that of responsible practice, to give mature consideration to the obligations and duties involved in the work of the Public Health Service, and to acquire direct experience of medical work in a responsible capacity, in general medical practice, in hQspital or laboratory appointments, or in any special branch of clinical work or study related to State Medicine."The examination for Part I embraces practical, written, and oral tests in the subjects set out in the Regulations of the curriculum relating to that part; and the same is true of the examination for Part II.A candidate must pass in all the subjects of Part I before being admitted to the examination for Part II.
Epidemic hypochlorhydria.
Authors: T Gledhill, R J Leicester, B Addis, N Lightfoot, J Barnard, N Viney, D Darkin, R H Hunt
Journal: BMJ (1985)

<h3>ABSTRACT</h3> Many non-emergency clinical services were suspended during COVID-19 pandemic peak. It is essential to develop a plan for restarting services following the peak. It is equally important to protect patients and staff and to use resources and personal protective equipment (PPE) efficiently. The British Society of Gastroenterology Endoscopy Committee and Quality Improvement Programme has produced guidance on how a restart can be safely delivered. Key recommendations include the following: all patients should have need for endoscopy assessed by senior clinicians and prioritised according to criteria we have outlined; once the need for endoscopy is confirmed, patients should undergo telephone screening for symptoms using systematic questionnaires; all outpatients should undergo RT-PCR testing for COVID-19 virus 1–3 days prior to endoscopy; and PPE should be determined by patient risk stratification, the nature of the procedure and the results of testing. While this guidance is tailored to endoscopy services, it could be adapted for any interventional medical discipline.
Randomized, double-blind, phase III trial of pazopanib versus placebo in women who have not progressed after first-line chemotherapy for advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer (AEOC): Results of an international Intergroup trial (AGO-OVAR16).
Authors: Andreas Du Bois, Anne Floquet, Jae Weon Kim, Jörn Rau, Jose Maria Del Campo, Michael Friedlander, Sandro Pignata, Keiichi Fujiwara, Ignace Vergote, Nicoletta Colombo, Mansoor Raza Mirza, Bradley J. Monk, Pauline Wimberger, Isabelle Ray-Coquard, Rongyu Zang, Ivan Diaz-Padilla, Klaus H. Baumann, Jae Hoon Kim, Philipp Harter
Journal: Journal of Clinical Oncology (2013)

LBA5503 Background: Pazopanib is an oral, multikinase inhibitor of VEGFR-1, -2, -3, PDGFR-α and -β, and c-Kit. Preclinical and clinical studies support VEGF(R) and PDGF(R) as targets for AEOC treatment. This study evaluated the efficacy, safety, and tolerability of pazopanib maintenance therapy in patients who have not progressed after first-line chemotherapy for AEOC. Methods: Patients with histologically confirmed AEOC, FIGO II-IV, and no evidence of progression after surgery and ≥ 5 cycles of platinum-taxane chemotherapy were randomized 1:1 to receive 800 mg pazopanib once daily or placebo for up to 24 months. Primary endpoint was progression-free survival (PFS) by RECIST. Secondary endpoints included overall survival, PFS by GCIG criteria, safety, and quality of life. Results: Most of the 940 randomized patients had stage III/IV disease (91%) at initial diagnosis, and no residual disease after surgery (58%). The median time from diagnosis to randomization was 7.1 months in the placebo arm and 7.0 months in the pazopanib arm. The median follow-up was 24 months. Patients in the pazopanib arm had a prolonged PFS vs placebo (HR = 0.766; 95% CI: 0.64-0.91; p = 0.0021; medians 17.9 vs 12.3 months, respectively). Sensitivity and subgroup analyses of PFS, and analysis of PFS by GCIG criteria, were consistent with the primary analysis. The first interim analysis for OS (only 189 OS events = 20.1% of population) showed no difference between arms. Pazopanib mean exposure was shorter vs placebo (8.9 vs 11.7 months). Pazopanib treatment was associated with a higher incidence of adverse events (AEs) and serious AEs (26% vs 11%) vs placebo. The most common AEs were hypertension, diarrhea, nausea, headache, fatigue, and neutropenia. Fatal SAEs were reported in three patients on pazopanib and one patient on placebo. Conclusions: Pazopanib maintenance therapy provided a statistically significant and clinically meaningful PFS benefit in patients with AEOC; OS data are not mature. The safety profile of pazopanib in this setting was consistent with its established profile. Clinical trial information: NCT00866697.
Early and long-term outcome data on 2,298 patients with pseudomyxoma peritonei of appendiceal origin treated by a strategy of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy.
Authors: Terence C. Chua, Brendan J. Moran, Paul H. Sugarbaker, Edward Allen Levine, Olivier Glehen, Francois N. Gilly, Dominique Elias, Dario Baratti, Marcello Deraco, Armando Sardi, David L. Morris
Journal: Journal of Clinical Oncology (2012)

532 Background: Pseudomyxoma peritonei (PMP) originating from an appendiceal mucinous neoplasm remains a biologically heterogeneous disease. The purpose of this study was to evaluate the outcome and long-term survival after cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) consolidated through an International Registry study. Methods: A retrospective multi-institutional registry was established through collaborative efforts of participating units affiliated with the Peritoneal Surface Oncology Group International (PSOGI). Results: 2298 patients from 16 specialized units underwent CRS for PMP. Treatment related mortality was 2% and major operative complication was 24%. The median survival was 196 months (16.3 years) and the median progression-free survival was 98 months (8.2 years) with a 10- and 15-year survival rate of 63% and 59% respectively. Multivariate analysis identified prior chemotherapy treatment (P&lt;0.001), PMCA histopathological subtype (P&lt;0.001), major postoperative complication (P=0.008), high PCI (P=0.013), debulking surgery (CCR2/3) (P&lt;0.001), not using HIPEC (P=0.030) as independent predictors for a poorer progression-free survival. Older age (P=0.006), major postoperative complication (P&lt;0.001), debulking surgery (CCR2/3) (P&lt;0.001), prior chemotherapy treatment (P=0.001) and PMCA histopathological subtype (P&lt;0.001) were independent predictors of a poorer overall survival. Conclusions: The combined modality strategy for PMP may be performed safely with acceptable morbidity and mortality in a specialized unit setting with 63% of patients surviving beyond 10-years. Minimizing non-definitive operative and systemic chemotherapy treatments prior to definitive cytoreduction may facilitate the feasibility and outcome of this therapy to achieve long-term survival. Optimal cytoreduction achieves the best outcomes.
Beneficial effects of combined colestipol-niacin therapy on coronary atherosclerosis and coronary venous bypass grafts
Authors: D. H. Blankenhorn
Journal: JAMA (1987)

The Cholesterol-Lowering Atherosclerosis Study (CLAS) was a randomized, placebo-controlled, angiographic trial testing combined colestipol hydrochloride and niacin therapy in 162 nonsmoking men aged 40 to 59 years with previous coronary bypass surgery. During two years of treatment there was a 26% reduction in total plasma cholesterol, a 43% reduction in low-density lipoprotein cholesterol, plus a simultaneous 37% elevation of high-density lipoprotein cholesterol. This resulted in a significant reduction in the average number of lesions per subject that progressed (<i>P</i>&lt;.03) and the percentage of subjects with new atheroma formation (<i>P</i>&lt;.03) in native coronary arteries. Also, the percentage of subjects with new lesions (<i>P</i>&lt;.04) or any adverse change in bypass grafts (<i>P</i>&lt;.03) was significantly reduced. Deterioration in overall coronary status was significantly less in drug-treated subjects than placebo-treated subjects (<i>P</i>&lt;.001). Atherosclerosis regression, as indicated by perceptible improvement in overall coronary status, occurred in 16.2% of colestipol-niacin treated vs 2.4% placebo treated (<i>P</i>=.002). (<i>JAMA</i>1987;257:3233-3240)
COMPLETE DISCISSION OF THE LENS BY THE V-SHAPED METHOD
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
<i>QuickStats</i>: Brain Cancer Death Rates Among Children and Teens Aged 1–19 Years,* by Sex† and Age Group — United States, 2013–2015
Journal: MMWR Morbidity and Mortality Weekly Report (2017)

The death rate for brain cancer, the most common cancer cause of death for children and teens aged 1-19 years, was 24% higher in males (0.73 per 100,000) than females (0.59) aged 1-19 years during 2013-2015. Death rates were higher for males than females for all age groups, but the difference did not reach statistical significance for the age group 5-9 years. Death rates caused by brain cancer were highest at ages 5-9 years (0.98 for males and 0.85 for females).
Lectures on the Principles of Surgical Diagnosis: Especially in Relation to Shock and Visceral Lesions
Authors: F. Le Gros Clark
Journal: BMJ (1868)

WHmN honoured by being elected to the Professorship of Human Ana- tomy and Surgery in this College, the duties of which I am now about to fAlfil, I beme sensible of the difficulty of seecting a suitable subject on which to address so learned an audience.My attention has not been directed toany branch of anatomy or surgery the special cultivation of
Accumulation of Ingested Asbestos Fibers in Rat Tissues over Time
Authors: Kusum Patel-Mandlik, James Millette
Journal: Environmental Health Perspectives (1983)

With the use of the transmission electron microscope, asbestos fibers have been assessed in kidney cortex of four groups of rats previously exposed to intermediate-range feeding grade chrysotile asbestos. Newborn rats, from mothers gavaged with asbestos during pregnancy, were gavaged twice a week at the dose level of 50 mg/kg beginning at age day 7 until their natural death or sacrifice. The rats were divided into four groups by age: 0-200, 200-400, 400-600 and 600-800 days. Of the 20 rats comprising the four test groups, 17 were positive, average fiber recovery being 5.34 X 10(3)/mg dry weight. Average fiber level in control tissues was 0.23 X 10(3)/mg dry weight. Fiber recovery in tissues from control animals was shown to be significantly lower (p less than 0.005) than that from test tissues. Test groups showed highly significant differences (p less than 0.005) from each other in the fiber levels. Dose-response relationship was not significant (0.05 less than p less than 0.1). The length distribution and the alterations in morphology of the recovered fibers are described. This study is consistent with the passage of chrysotile asbestos across the gastrointestinal wall.
CONTINUING MEDICAL EDUCATION—A PROFESSIONAL RESPONSIBILITY
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Highlights
Journal: JAMA Psychiatry (2016)

Prediction of Response to Electroconvulsive Therapy 557Electroconvulsive therapy (ECT) is one of the most eff ective treatments for severe depression, but response prediction has been elusive.Redlich and colleagues used structural magnetic resonance imaging to predict ECT response in acutely depressed patients.Response was predicted correctly in 18 of 23 patients treated with ECT and in 13 of 13 patients who responded to ECT.In an editorial, Abbott and colleagues discuss the value of machinelearning approaches for the prediction of ECT response.
Study design
Authors: P. Sedgwick
Journal: BMJ (2010)

Researchers investigated the direct impact of hip fracture on mortality in a cohort of individuals aged over 65 years living in a geographically defined area in western Sydney, Australia.1 At baseline, no one in the cohort had ever experienced a hip fracture. The cohort was followed prospectively over an 18 month study period, during which 211 cases of hip fracture occurred. A total of 201 controls who had not experienced a hip fracture were selected at random from the same cohort. When identified, both cases with hip fracture and controls were subsequently followed for a further year. One year mortality among individuals with hip fracture was 21.7%, compared with 4.7% for controls. Which one of the following terms best describes the above study design?
First Human Death Associated With Raccoon Rabies—Virginia, 2003
Journal: JAMA (2003)

Rabies is an acute, progressive, incurable viral encephalitis, caused by the bite of an infected animal. In March 2003, a previously healthy man aged 25 years from northern Virginia died from a diagnosed illness of meningoencephalitis of unknown etiology after a 3-week illness. Histopathologic review of central nervous system tissues at CDC revealed viral inclusions suggestive of Negri bodies, and subsequent tests confirmed a diagnosis of rabies. Genetic sequencing identified a rabies virus variant associated with raccoons, but how the patient became infected remains unknown. This report summarizes the investigation of the first documented case of human rabies associated with a raccoon rabies virus variant in the United States and highlights the importance of continued education in the prevention and diagnosis of rabies.
Apolipoprotein E ϵ4 and the Risk of Dementia With Stroke&lt;subtitle&gt;A Population-Based Investigation&lt;/subtitle&gt;
Authors: Arjen J. C. Slooter
Journal: JAMA (1997)

<h3>Objective.</h3> —To investigate the association between the apolipoprotein E (<i>APOE</i>) genotypes and dementia in patients with stroke, defined as either vascular dementia (VaD) or Alzheimer disease with cerebrovascular disease (AD with CVD). <h3>Design and Setting.</h3> —Population-based, case-control study from Rotterdam, the Netherlands, and New York City. <h3>Participants.</h3> —A total of 187 patients with dementia and stroke were compared with 507 controls similar in age and ethnic group. <h3>Main Outcome Measures.</h3> —The<i>APOE</i>allele frequencies in patients and controls; the odds ratio of dementia with stroke, VaD, and AD with CVD, adjusted for age, sex, residency, and education; and the percent attributable risk related to the<i>APOE</i>ϵ4 allele. <h3>Results.</h3> —Overall, patients with dementia and stroke had a higher<i>APOE</i>ϵ4 allele frequency than controls. Compared with<i>APOE</i>e3 homozygote individuals,<i>APOE</i>ϵ4 homozygotes had a 7-fold increased risk of dementia with stroke (OR=6.9; 95% CI, 1.6-29.4), while<i>APOE</i>ϵ4 heterozygotes had nearly a 2-fold increase in risk (OR=1.8; 95% CI, 1.2-2.7). Risks associated with<i>APOE</i>ϵ4 were elevated regardless of the subtype of dementia with stroke or age or sex. The percent attributable risk related to the<i>APOE</i>ϵ4 allele among demented patients with stroke was 41% overall, 33% among those with VaD, and 44% among those with AD with CVD. <h3>Conclusion.</h3> —The<i>APOE</i>ϵ4 allele is a genetic risk factor for dementia with stroke, including VaD and AD with CVD. This may imply shared genetic susceptibility to dementia associated with stroke and AD. Alternatively, the category of patients with dementia and stroke, including VaD as currently defined, may include patients with AD.
POST-WAR MEDICAL EDUCATION
Authors: W. H. B.
Journal: Annals of Internal Medicine (1945)

Editorial1 November 1945POST-WAR MEDICAL EDUCATIONW. H. B.W. H. B.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-23-5-890 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe sudden and unexpected end of World War II in August has given rise to a number of new problems in medical education which the medical schools and hospitals of this country were scarcely better prepared to meet than were industry and labor in general. Or more specifically, the following problems now confront us: (1) deceleration of the medical school program; (2) the admission of veterans to the medical schools; (3) post-graduate training of veterans who entered the medical service of the Army or Navy with hospital training inadequate to prepare them for the practice of medicine; and (4) clinical... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1945Volume 23, Issue 5Page: 890-892KeywordsHospital medicineMedical educationMedical services ePublished: 1 December 2008 Issue Published: 1 November 1945 PDF downloadLoading ...
Binge Drinking During Pregnancy as a Predictor of Psychiatric Disorders on the Structured Clinical Interview for DSM-IV in Young Adult Offspring
Authors: Helen Barr
Journal: American Journal of Psychiatry (2006)

Objective: This study explored the extent to which the high frequency of psychiatric problems reported in clinical groups with fetal alcohol spectrum disorders might also be observed in a nonclinical group of young adults and the psychiatric conditions that are related to prenatal alcohol exposure in this group. Method: From a longitudinal prospective study beginning with interviews of 1,529 pregnant women, a birth cohort of about 500 newborns was chosen to include all of the most heavily alcohol exposed plus a sampling of the continuum of alcohol exposures from total abstinence through heavy drinking. At an average age of 25.7 years, 400 members of this birth cohort were administered valid Structured Clinical Interviews for DSM-IV (SCID), including both the SCID for axis I disorders and the SCID for axis II personality disorders. Results: The odds of the appearance of six psychiatric disorders and traits were more than double in adults exposed to one or more binge alcohol episodes in utero. Three of these six odds ratios were uniformly stable against confounding: axis I substance dependence or abuse disorders and axis II passive-aggressive and antisocial personality disorders or traits. Conclusions: Prenatal exposure to alcohol may be a risk factor for specific psychiatric disorders and traits in early adulthood, even in a nonclinical group.
Book Review The Elements of the Science of Nutrition . (Fourth Edition, Reset.) By Graham Lusk, PH.D., SC.D., Professor of Physiology at the Cornell University, Medical College, New York City. Fourth Edition. Reset. Octavo of 844 pages. Philadelphia and London: W. B. Saunders Company, 1928. Cloth $7.00 Net.
Journal: New England Journal of Medicine (1928)
The Hyde Amendment in action. How did the restriction of federal funds for abortion affect low-income women?
Authors: W. Cates
Journal: JAMA (1981)

In August 1977 the Hyde Amendment, which restricts the use of federal funds for abortion, was implemented; it remained in operation during the next 2% years. During this interval, the Hyde Amendment was effective in nearly eliminating federally financed abortions. However, an estimated 94% of pregnant, low-income women "at risk" obtained a legal abortion, 65% with state funds and 29% with other sources of funding. About 5% of low-income women continued their pregnancies to term, while only an estimated 1% resorted to illegal abortion. These results are contrary to the predictions of both "pro-life" and "pro-choice" advocacy groups. (<i>JAMA</i>1981;246:1109-1112)