tbuckley/cabot-search huggingface dataset:
PHTHISIS AND INSANITY.
Journal: JAMA (1898)

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Acute respiratory illness in an American community. The Tecumseh study
Authors: A. S. Monto
Journal: JAMA (1974)

Approximately 14,600 cases of respiratory illness in 4,905 residents of Tecumseh, Mich, were studied during a six-year period. The annual incidence of respiratory illness for each individual was calculated. Rates decreased with age except during the 20- to 29-year decade. In children less than 3 years of age, males experienced more illnesses than females; in those older than that, the reverse was true. Frequency of physician consultation varied with illness type. Rhinoviruses were the most frequently isolated pathogen from all illnesses. From those associated with physician consultation, group A hemolytic streptococci were nearly as frequently isolated. More illnesses started on Monday than on any other day of the week. Illness frequency increased with education of head of household, but decreased with family income. Therefore, highest rates were observed in more educated families with low income.
Journal of Applied Physiology, Washington
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Treatment of bedwetting
Authors: M. A. Stewart
Journal: JAMA (1975)

A CONTEMPORARY expert might suggest three forms of treatment for the rascal: advice and encouragement, prescribing antidepressants, or conditioning with an alarm system. The three methods are reviewed in this communication, together with the evidence for their effectiveness. The first method is old and tried, but few data are available on its success; the use of antidepressants has been subjected to rigorous and well-controlled study; and while conditioning does not lend itself to controlled research, careful reports exist on its use that can be compared to the results of other approaches. These are the treatments most often used in the United States, Britain, Canada, and Australia, but several others must be mentioned: bladder training, surgery, psychotherapy, and other drug regimens. The functional capacity of an enuretic child's bladder is smaller, on the average, than that of a normal child, and becoming "dry" may be associated with an increased capacity.<sup>1-3</sup>The
GMC's Professional Conduct Committee
Journal: BMJ (1981)

committees about the dispersal of vacant medical practices, the GMSC should look at the effect of delays in decisions being reached on such issues, and seek guidance from the DHSS on what is 'sufficient time' for consultation and how long an appeal by a community health council to the Secretary of State might take."The committee decided, as a matter of urgency, to look at the whole question of family practitioner commlittee consultation with community health councils.
ENDOSCOPIC REMOVAL OF SAND SPURS FROM LARYNX AND TRACHEOBRONCHIAL TREE
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Histoplasmosis, 1962
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Birth and death of congenital rubella syndrome
Authors: S. A. Plotkin
Journal: JAMA (1984)

Diseases, like humans, are born and die. An example of a recent birth is legionnaires' disease, unrecognized before 1976; measles illustrates the decline and fall of a disease once common. Now we have congenital rubella syndrome as another potential example of the birth and death of a disease.<sup>1</sup> Gregg's<sup>2</sup>discovery of the association between rubella and congenital infection was made in 1948. Presumably the congenital rubella syndrome had not become evident earlier because, in crowded societies, infection with rubella occurs at a young age, especially when children are placed together in communal nurseries.<sup>3</sup>Thus, only in developed countries, where many women escape infection until their childbearing years, could the congenital rubella syndrome manifest itself. The years between 1941 and 1962 brought general recognition of the teratogenic potential of rubella, such that several laboratories set as their goal the isolation of the virus. Attainment of that goal was
Gene-environment interaction in the regulation of HDL: The hepatic lipase gene promoter polymorpism modulates the physical activity associated increase in HDL
Authors: John E Hokanson, Richard F Hamman, Robert H Eckel, M Ilyas Kamboh
Journal: Circulation (2001)

P08 HDL-C is an important protective factor for coronary heart disease. Physical activity raises HDL-C, although the effect varies among individuals. The hepatic lipase (HL) promoter polymorphism (HL-514C→T) is associated with HDL-C. This study addresses the question: is the relationship between physical activity and HDL-C altered by an individual’s HL promoter polymorphism genotype? Non-diabetic subjects from the San Luis Valley Diabetes Study provided a 7 day physical activity recall from which metabolic equivalents (METS) were calculated. Anthropomorphic measures and fasting blood for lipid and DNA analysis were also collected. Women were excluded if postmenopausal or taking estrogen, resulting in 248 Hispanic and 363 non-Hispanic White (NHW) subjects. The frequency of the HL-514T allele was 0.18 in NHW compared to 0.47 in Hispanics (p&lt;0.001). Women had higher HDL-C than men (52±13 vs. 45±11, p&lt;0.001). The HL-514T allele was associated with higher HDL-C in men (46±12 vs. 44±11 for HL-514CC, p&lt;0.03), but not in women (51±13 vs. 52±13 for the HL-514CC, p=0.5). METS were positively related to HDL-C in both men and women(r=0.18, p=0.001; and r=0.20, p&lt;0.01, respectively). Multivariate analysis showed a statistically significant interaction between METS and the HL-514 allele on HDL-C (p&lt;0.001). That is, subjects with the HL-514T allele showed less of an effect of METS on HDL-C compared to HL-514CC (slope=0.01, p=0.08 vs. slope=0.03, p=0.005, respectively), after adjusting for age, sex, ethnicity, BMI, waist/hip ratio, and log triglyceride. BMI was also independently related to HDL-C (p&lt;0.0001). Thus, in this free living rural community, the beneficial effects of physical activity on HDL-C are modulated by the hepatic lipase gene promoter polymorphism. Individuals with the HL-514T allele are more resistant to exercise associated higher HDL-C. The allele-specific effects of physical activity on HDL-C were independent of body fat and fat distribution. This suggests a genotype-specific targeted approach of exercise intervention to raise HDL and reduce coronary disease risk may be warranted.
Comparison of P wave duration between signal averaged ECG and 12 lead ECG in predicting early recurrence of atrial fibrillation following direct current cardioversion Xiaohua Guo, Katerina Hnatkova, Mark M. Gallagher, Monica Harries, A. John Camm, Marek Malik. St George's Hospital Medical School, London, United Kingdom
Journal: Journal of the American College of Cardiology (2001)
Symptoms in Diagnosis
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Boerhaave Syndrome
Authors: Donald J. Fleischli
Journal: JAMA (1966)

A great teacher and chemist, Hermann Boerhaave (1668-1738) was born in Voorhout, Holland, near Leyden. After studying medicine at the University of Harderwijk, he entered practice in Leyden. In 1714 he was elected Rector of the University of Leyden, where he organized the famous Leyden Clinic. Eponymically he is remembered by "Boerhaave's syndrome" and by "Boerhaave's sweat glands" of the skin. In 1732 Boerhaave published<i>Elementa Chemiae</i>, a textbook of chemistry which was the laading text during the 18th century (Newerla, G.J.: Medical History in Philately, American Topical Association, Milwaukee, 1964, pp 17-18.)
THE PREVENTION OF COLDS, AND THEIR SEQUELAE, BY SURGICAL METHODS.
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Studies of rubella and its prevention with immune globulin
Authors: T. C. Doege
Journal: JAMA (1967)

During a rubella epidemic the effects of immune globulin (0.5 cc/kg of body weight) on rash, virus-shedding, and serologic conversion were prospectively tested. If virus excretion or a fourfold titer increase represent infection, then 34 of 43 persons were infected, of whom ten had apparent disease, giving a ratio of two inapparent infections for every apparent infection. The difference in rates of infection between test and control groups was insignificant, but fewer virus isolations were made in the test group than in the control group. Virus isolations and occurrence of rash were inversely related to baseline antibody levels. Isolates were made as early as 12 days before and as late as 45 days after the appearance of rash. A 16-year-old girl with the congenital rubella syndrome had a rubella reinfection. Generalized adenopathy, enanthem, mild fever, leukopenia, and an increased sedimentation rate were features of the acute illness.
Acute/Chronic respiratory failure II
Authors: H. Georges, N. Gueteau, O. Leroy, C. Santré, C. Beuscart, H. Medaoui, C. Lemaire, G. Beaucaire, I. Cabezas, H. Romo, E. Salazar, M. Narváez, D. Pinquier, G. Boussignac, D. Pavlovic, M. Aubier, F. Beaufils, J. C. Raphael, F. Bouvet, S. Chevret, Cl. Chastang, R. Boiteou, T. Lherm, F. Marcier, F. Chamieh, D. Perrin, A. Tenaillon, J. M. Gabillet, B. Guidet, F. Staikowsky, G. Offenstadt, P. Amstutz, C. Truchero, J. Moya, A. Diaz-Prieto, F. Konrad, R. Schiener, J. Kilian, M. Georgieff, F. Salord, V. Cayrel, A. Peloux, S. Tixier, R. Chacornac, A. Durocher, A. M. Durocher, C. Gires, L. Behr, F. Saulnier, L. Gruez, F. Boileau, Ph. Dewailly, H. Wiedeck, R. Boiteau, T. Lherm, D. Perrin-Gachadoat, E. Valente, H. Hmouda, A. Fatrane, L. Fakhfakh, N. Bloch, B. Rousset, J. H. Boix, J. Marin, A. Amau, M. Tejeda, D. Olivares, E. Servera, M. Dambrosio, M. Dojat, D. Touchard, A. Harf, F. Lemaire, L. Brochard, C. Tormo, V. Lópes, V. Parra, R. Calvo, V. Lacueva, J. L. Maravall, A. Carneiro, B. Huet, C. Brun-Buisson, A. J. Schneider, A. B. J. Groeneveld, L. G. Thijs, R. I. C. Wesdorp, B. Lafon, M. Denis, T. Vassal, C. Mayaud, M. Högman, H. Hedenström, C. Frostell, H. Arnberg, G. Hedenstierna, J. -A. Romand, M. R. Pinsky, L. Firestone, J. R. Lancaster, H. Zar, F. Brunet, M. Belghith, J. P. Mira, J. J. Lanore, B. Renaud, F. Pochard, J. F. Vaxelaire, I. Hamy, A. Armaganidis, J. Dall’ava, J. F. Dhainaut, P. Navalesi, F. Maltais, A. Gursahanev, P. Hernandez, M. Sovili, S. Gottfried, L. Gregorakos, C. Katsanos, V. Malessios, J. Nicoiopoulos, L. Tsaldari, M. Kountouri, M. T. Martín, F. J. Santos, S. Iribarren, A. Fernández, G. Diaz-Regañón, Ch Martínez, Yu. Sirenko, O. Sychev, M. Shchupak, L. Babiy, J. Muñoz, F. Ruiz, J. Blanquer, M. Simó, A. Herrejón, C. Núñez, E. Chiner, S. Nouira, S. Elatrous, A. Bchir, M. Jaafoura, F. Abroug, S. Bouchouha, S. Bahrami, Y. Yu, H. Redl, G. Schlag, G. Conti, A. Cogliati, D. Dell’Utri, A. Ferretti, R. Traversa, L. Di Chiara, P. Marino, J. Kesecioĝlu, J. C. Pompe, I. Gültuna, C. Ince, W. Erdmann, H. A. Bruining, J. Castañeda, J. Blanco, C. Aldecoa, T. Boulain, Y. Furet, P. F. Dequin, A. Legras, D. Perrotin
Journal: Intensive Care Medicine (1992)
IMMU-10. USE OF A SINGLE PEPTIDE CHECKPOINT INHIBITOR FOR TREATMENT OF CENTRAL NERVOUS SYSTEM TUMORS
Authors: Christopher Moertel, Zhengming Xiong, G-Elisabeth Pluhar, Michael Olin
Journal: Neuro-Oncology (2021)

Abstract Cancer immunotherapy has revolutionized clinical management of malignancies by generating long-term, durable control of tumors. Unfortunately, these therapies often cause serious immune-related adverse events. In addition, only a small percentage of solid tumors respond to these therapies and there is little efficacy in CNS tumors. Our research is focused on the CD200 immune checkpoint, which modulates the immune system through the inhibitory receptor (CD200R1) and activation receptors (CD200AR). We demonstrated that targeting the CD200AR with a checkpoint peptide ligand (CD200AR-L) activates the immune system and renders it impervious to the inhibitory effects of CD200. In a pre-clinical canine spontaneous high-grade glioma trial, CD200AR-L, with autologous tumor lysate vaccination, resulted in a 20% two-year progression-free survival; no toxicities or adverse effects were observed. We suggest this result was due to the ability of the CD200AR-L to modulate multiple immune checkpoints. During the characterization of the CD200AR-L, we discovered signaling molecules are shared by the CD200 and PD-1/PD-L1 checkpoint pathways, suggesting these immune checkpoints are connected. Our preliminary studies demonstrated that the inhibitory CD200R1 and PD-1 mediate immune checkpoint signaling activities through the SHIP1/2. Moreover, CD200AR-L overpowers the suppressive effects of CD200 and PD-L1, which are both shed by tumors, by downregulating the inhibitory CD200R1 and PD-1 on both antigen-presenting cells (APC) and T-cells. In addition, CD200AR-L downregulates PD-1 on APCs and inhibits the upregulation of PD-L1 and CTLA4. These studies led to the discovery that the novel peptide modulates the CD200, PD-1/PD-L1 and CTLA-4 pathways, providing the basis for the translatable development of a CD200-directed peptide for clinical use against multiple tumors including gliomas. These studies led to FDA approval of this peptide for the first in human phase I single center, open-label, dose-escalation clinical trial (NCT04642937) in adult and pediatric trial for children with recurrent malignant brain tumors.
INFLUENZAL PERICARDITIS
Authors: RUTH E. TAYLOR
Journal: JAMA (1927)

Although a vast amount of work has been done to determine the etiology of influenza and a voluminous literature on the subject has accrued, it is not certain that the influenza bacillus causes the disease. Bronchopneumonia in which the influenza bacillus has been the only demonstrable organism present is not infrequent. Cases of purulent meningitis, nearly always fatal, have occurred in which the influenza bacillus alone was found. In 1897, Fraenkel<sup>1</sup>reported two such cases, in which at autopsy the meninges were covered with exudate and bathed in green yellow pus. The organisms which were found in direct smears of the exudate were both phagocytized and free. Pericarditis complicating pneumonia and empyema was frequently reported during the epidemic of 1918-1919 and 1920. In 300 necropsies of patients dying of influenzal pneumonia, reported by Stone,<sup>2</sup>pericarditis was found in 24 per cent and was usually secondary to empyema. The
Plesiomonas shigelloides—Associated Diarrhea
Authors: John F. Reinhardt
Journal: JAMA (1985)

<i>Plesiomonas shigelloides</i>was thought to be the cause of diarrhea in six patients seen in Los Angeles. Although this organism is considered to be a cause of diarrhea in the Orient, it has infrequently been noted to be associated with diarrhea in North America. (<i>JAMA</i>1985;253:3294-3295)
AUTOINTOXICATION.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal