tbuckley/cabot-search huggingface dataset:
Nick Kitson
Authors: R. Laugharne
Journal: BMJ (2014)

<h3>Objectives</h3> Neurosarcoidosis may present with longitudinally extensive transverse myelitis (LETM) posing a diagnostic challenge. We describe the clinical features, radiology and management of five patients with spinal neurosarcoidosis (SNS). <h3>Methods</h3> We retrospectively identified five patients with a diagnosis of SNS and the clinical, radiological and pathological data were reviewed. <h3>Results</h3> There were three females and two males who were, on average, 49 years at onset. A histopathological diagnosis of sarcoid was confirmed in two cases (lymph node and cerebral lesion) and the diagnosis was radiological in the others (LETM with persistent enhancement in 3 patients and the trident sign in 2 patients). The average span of the spinal cord lesions was 4 vertebral bodies. Three patients had FDG-avid mediastinal lymph nodes. Cerebral disease was identified in two cases, and cardiac involvement in one. Two patients required spinal decompression surgery. All patients received intravenous and oral steroids and some had rituximab (n=2), tocilizumab (n=1), cyclophosphamide(n=1), adalimumab (n=2), and infliximab (n=4). Disease control was achieved with TNF-alpha (tumour necrosis factor-alpha) blocking in 4 cases and another responded to cyclophosphamide. The mean follow-up was 55 months. <h3>Conclusions</h3> SNS is a cause of LETM and can be suspected by the trident sign on MRI. Persistent enhancement may be another differentiating feature. Spinal cord oedema requiring surgery may occur and patients typically respond to treatment with TNF-alpha inhibitors. <h3>References</h3> Flanagan EP, Kaufmann TJ, Krecke KN, Aksamit AJ, Pittock SJ, Keegan BM, Giannini C, Weinshenker BM. Discriminating long myelitis of neuromyelitis optica from sarcoidosis. <i>Ann Neurol</i> 2016 Mar;79(3):437–47. Zalewski NL, MD, Krecke KN, Weinshenker BG, MD, Aksamit AJ, Conway BL, McKeon A, Flanagan EP. Central canal enhancement and the trident sign in spinal cord sarcoidosis. <i>Neurology</i> 2016 Aug 16;87(7):743–4.
FATAL HYSTERICAL HEMOPTYSIS.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Significant Linkage to Compulsive Hoarding on Chromosome 14 in Families With Obsessive-Compulsive Disorder: Results From the OCD Collaborative Genetics Study
Authors: Jack Samuels
Journal: American Journal of Psychiatry (2007)

Objective: Individuals with obsessive-compulsive disorder (OCD) who have compulsive hoarding behavior are clinically different from other OCD-affected individuals. The objective of this study was to determine whether there are chromosomal regions specifically linked to compulsive hoarding behavior in families with obsessive-compulsive disorder. METHODS: The authors used multipoint allele-sharing methods to assess for linkage in 219 multiplex OCD families collected as part of the OCD Collaborative Genetics Study. The authors treated compulsive hoarding as the phenotype of interest and also stratified families into those with and without two or more relatives affected with compulsive hoarding. Results: Using compulsive hoarding as the phenotype, there was suggestive linkage to chromosome 14 at marker D14S588 (Kong and Cox logarithm of the odds ratio [LOD] [KAC all =2.9]). In families with two or more hoarding relatives, there was significant linkage of OCD to chromosome 14 at marker C14S1937 (KAC all =3.7), whereas in families with fewer than two hoarding relatives, there was suggestive linkage to chromosome 3 at marker D3S2398 (KAC all =2.9). Conclusions: The findings suggest that a region on chromosome 14 is linked with compulsive hoarding behavior in families with OCD.
Abstract 5226: Non-canonical functions of TERT in glioblastoma pathobiology
Authors: Shayesteh R. Ferdosi, Saumya Bollam, Sen Peng, Brett Taylor, Vijay Gokhale, Laurence Hurley, Michael Berens, Harshil Dhruv
Journal: Cancer Research (2019)

Abstract Mutations in the promotor region of TERT are the most common non-coding mutations across cancers, especially in glioblastoma (GBM), which has a TERT mutation frequency rate over 80%. In the absence of any effective molecular targeting therapy for GBM, elucidating oncogenic signaling of TERT could open new avenues in GBM treatment. Canonically, mutations of TERT, which result in TERT upregulation, maintain telomere length in the nucleus and promote indefinite proliferation of cancer cells. However, a non-canonical function of TERT in the mitochondria has recently been suggested. We screened GBM cell models against a novel small molecule inhibitor (RG1534, Reglagene Inc.) that interferes with the functionality of a mutated hTERT promoter. RG1534 selectively suppresses glioma cell viability without affecting non-transformed normal human astrocytes. More interestingly, RG1534 treatment leads to rapid apoptosis induction in glioma cell lines that does not correlate with the time course of the telomere shortening effect. We further validated this rapid apoptosis behavior in glioma cell lines using siRNA and CRISPR/Cas-9 mediated hTERT knockdown. We also measured the protein expression of TERT in subcellular fractions of glioma cell lines and demonstrated the presence of higher TERT expression in mitochondrial extract compared to the nuclear extract. Finally, using MitoSOX dye we demonstrated significant increase of ROS generation in glioma cells treated with RG1534 as compared to control. In summary, our results demonstrate that non-canonical functions of TERT may play critical role in glioma pathobiology and require more detail investigation. Citation Format: Shayesteh R. Ferdosi, Saumya Bollam, Sen Peng, Brett Taylor, Vijay Gokhale, Laurence Hurley, Michael Berens, Harshil Dhruv. Non-canonical functions of TERT in glioblastoma pathobiology [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 5226.
Adoptions
Authors: Ralph A. Ross
Journal: New England Journal of Medicine (1964)

AS stated in 1955, "It is advantageous for any child of any age to be placed for adoption if he does not have a family of which he is a part — any child can be considered adoptable who can gain from family life and who has the capacity to develop in a normal environment."1 There is an increasing number of live births out of wedlock occurring in the United States, from 3.6 per cent in 1947 to 5.3 per cent in 1959. In 1962 121,000 children were legally adopted in this country, 48 per cent by relatives and 52 . . .
Serum cholesterol and death from coronary heart disease
Authors: R. E. Olson
Journal: JAMA (1987)

<h3>In Reply.—</h3> In reply to Dr Olson, 95% confidence limits were in fact given in our article, contrary to Dr Olson's statement. For the age-standardized six-year coronary mortality rates for the quintiles of baseline serum cholesterol level (death rates of 3.2, 4.2, 5.6, 7.1, and 11.1 per 1000, respectively), the 95% confidence limits are 2.8 to 3.7, 3.7 to 4.7, 5.0 to6.2,6.5 to 7.7, and 10.3 to11.9. Coronary death rates for men in quintiles 2, 3, 4, and 5—with serum cholesterol levels of 182 to 202, 203 to 220, 221 to 244, and ≥245 mg/dL, respectively (4.70 to 5.20, 5.25 to 5.70, 5.70 to 6.30, and ≥6.35 mmol/L)—were significantly and progressively higher than those for men in quintile 1, with serum cholesterol levels of 181 mg/dL or lower (≤4.70 mmol/L), ie, 80% of these men were at excess risk of coronary death. For each of the five age groups, serum
Histamine excess in plasma cell leukemia. A case with unusual clinical manifestations
Authors: T. Srichaikul
Journal: JAMA (1975)

PLASMA cell leukemia is a very rare form of immunocytic dyscrasia. Clinical course, laboratory findings, therapy, and prognosis of the disease were discussed recently by Pruzanski et al,<sup>1</sup>who reviewed 57 cases reported in the literature during the last 20 years. The clinical picture varies from the terminal leukemic stage of an otherwise classical multiple myeloma to a fulminating course of acute leukemia. On initial examination, our patient had episodes of vascular hyperactivity and high-output cardiac failure. Blood histamine level was found to be strikingly elevated with each episode. To our knowledge, this clinical manifestation has not been reported previously. <h3>Report of a Case</h3> A 27-year-old man was admitted on April 7, 1970, with a four-month history of intractable ascites and congestive cardiac failure. Physical examination showed an orthopneic young man with a blood pressure of 100/70 mm Hg; pulse, 96 beats per minute; respirations, 26/min; temperature, 36.8 C
Heart Transplantation after Ten Years
Authors: W. Gerald Austen
Journal: New England Journal of Medicine (1978)

More than 10 years have passed since the first successful human heart transplantation.1 After an initial flurry of excitement, and widespread trial in many centers, recurrent failures led to disillusionment and virtual abandonment of the procedure, in all but one or two institutions. Since 1970 the vast majority of transplants in this country have been carried out in the experimental program under the direction of Shumway and his surgical and medical colleagues at Stanford. As of January 1, 1978, approximately 360 transplants had been carried out worldwide, 137 of them at Stanford. It is now apparent that for a very . . .
The management of infection in the cancer patient
Authors: P. H. Wiernik
Journal: JAMA (1980)

INFECTION is a leading cause of death in patients with cancer, especially those with hematologic malignant neoplasms such as leukemia and lymphoma. It therefore follows that control of infection will not only reduce suffering among such patients but will, in fact, extend life in these patients who represent a variety of compromised hosts. <h3>Infection Prevention</h3> The most important step in control of infection in the cancer patient is prevention. Cancer patients are at risk for infection by a variety of organisms, including normal flora found in the patients' internal (alimentary and respiratory tracts) environment and those acquired organisms found in the external (air, food, and water) environment. A number of expensive yet effective devices (laminar air-flow room) have been developed to allow complete reverse isolation of the compromised host, including provision of essentially sterile air.<sup>1,2</sup>However, the initial expense and the operating costs of such units have made them
Book on Scientific Writing
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Omitted Dates of Ethical Approval and Timing of Patient Recruitment
Authors: Marianthi-Anna Kioumourtzoglou, Marc Weisskopf
Journal: JAMA Pediatrics (2018)

Biswanath Basu, MD; Anja Sander, PhD; Birendranath Roy, MD; Stella Preussler, MSc; Shilpita Barua, MD; T. K. S. Mahapatra, MD; Franz Schaefer, MD
Infectious Diseases
Authors: David M. Hecht
Journal: Annals of Internal Medicine (1998)

Medical Writings1 May 1998Infectious DiseasesDavid M. Hecht, MDDavid M. Hecht, MDLoyola University Stritch School of Medicine, Maywood, IllinoisSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-9-199805010-00047 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Infectious Diseases; 2nd edition. Gorbach SL, Bartlett JG, Blacklow NR. 2594 pages. Philadelphia: WB Saunders; 1998. $225.00. ISBN 072166119X. Order phone 800-545-2522.Field of medicine: Infectious diseases.Format: Hardcover book.Audience: Clinicians in infectious diseases, fellows in training, and physicians seeking an authoritative reference on clinical infectious diseases.Purpose: To provide a comprehensively updated, authoritative text on all aspects of infectious diseases.Content: All chapters from the previous edition of this text have been rewritten and updated, and new chapters on AIDS, emerging infections, and antimicrobial resistance have been added. Other new topics addressed include molecular diagnostics and probes, polymerase ... Author, Article, and Disclosure InformationAffiliations: Loyola University Stritch School of Medicine, Maywood, Illinois PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1998Volume 128, Issue 9Page: 791-792KeywordsInfectious diseasesKawasaki diseaseMicrosporidiaMicrosporidiosisMolecular pathologyPneumoniaPolymerase chain reactionSoft tissue infectionsToxic shock syndromeUlcers ePublished: 15 August 2000 Issue Published: 1 May 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
MOUNTAINS AND MEDICINE
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Practical Treatise on Materia Medica and Therapeutics, with Especial Reference to the Clinical Application of Drugs.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
WITHERING'S "DIURETIC HERB"
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Letter: A place to be born.
Journal: BMJ (1976)

possibility of separating aid from politics is remote.On this score, for example, would the United States be content to build 30 health centres in relatively inaccessible rural areas while a large USSR-built hospital stood supreme in the capital?Publicity thus tends to carry more weight than utility, and size is made a virtue.And it must be admitted in fairness that indigenous authorities have often been swayed by the favourable domestic publicity that "vast structures" can bring.Never- theless, the indigenous adviser has so far played a limited part in deciding to build them.
Library of the Royal Society of Medicine
Journal: BMJ (1953)

the neglect of genito-urinary work at our large London general hospitals, the teaching on such subjects as syphilis and gonorrhoea having been lamentable, and the opportunities of students for obtaining first-hand knowledge meagre in the extreme.Consider seriously this advice given to a patient of mine, an officer under treatment in one of our largest naval hospitals, " Massage your own prostate daily " -surely a feat within the compass only of the domestic cat.I am, Sir, yours faithfully,
Participant Index
Authors: Ainsworth Rl, Alexander Mf, Alfarano 149, Aron Rosa, Arribas Np, Asbell Pa, Assia Astorino, O Bregman, Burks Wr, Busse Bj, Butrus S1138, Byrne Sf211, Byron Hm, Byron Mv, Cahill Fp, Cahill Kv220, Calhoun Jh, Cambie Ej, Catalano Ra, Cavanagh Hd, Cavender Jc, Chan Cc, Cheetham Jk, Chen Mc, Chenwp201 Chenoweth, Choyke Choyae225, Christmann Lm, H-C Chuang, Chumbley Lc, Chylack Jr, Cohen Kl, Cohen Ms, Cohen Sb, Colvard Dm, Colwell Ja, Cooper Ml, Corbett Jj, Corboy Jm, D Amico, Dailey Jp, Daily Mj, Dallow Rl221, Dannenberg Al, Kardon Rh, Karlin Db, Karp Ej, Kass Ma, Kastl Pr, Katownz Ja, Kallan Hm 145 Katz, Katz Lj, Katz Nnk, Katzen Lb, Katzen Le 230 Kaufman, Kaufman Lm, Kaymc224 Kaymd, Keates Rh, Keeney Ah, Keeney Vt, Kelley Cg, Kelley Ep, Kelley 99 Kellner, King Lm, Kinoshita 142 Kinoshita, Klaas Ow, Klein Hz, Kline Lb, Kramer Sg, Kraushar Mf, Kreiger Ae, Kreiswirth Bn, Kritzinger Ee, Kronish Jw, Kruse Fe, Kruth 141 Kuhn, Kulwin Dr, Kunesh Mt, Kutner Mh, Kwasny Gp, Kwiterovich Ka
Journal: Ophthalmology (1990)
In Vivo Effects of Chromium
Authors: Charlotte Witmer, Ellen Faria, Hyoung-Sook Park, Nakissa Sadrieh, Edward Yurkow, Sean O'Connell, Andrea Sirak, Heinz Schleyer
Journal: Environmental Health Perspectives (1994)

The production of reactive oxygen species on addition of hexavalent chromium (potassium dichromate, K2Cr207) to lung cells in culture was studied using flow cytometer analysis.A Coulter Epics Profile II flow cytometer was used to detect the formation of reactive oxygen species after K2Cr2O7 was added to A549 cells grown to confluence.The cells were loaded with the dye, 2',7'dichlorofluorescein diacetate, after which cellular esterases removed the acetate groups and the dye was trapped intracellularly.Reactive oxygen species oxidized the dye, with resultant fluorescence.Increased doses of Cr(VI) caused increasing fluorescence (10-fold higher than background at 200 pM).Addition of Cr(I) compounds, as the picoli- nate or chloride, caused no increased fluorescence.Electron paramagnetic resonance (EPR) spectroscopic studies indicated that three (as yet unidentified) spectral "signals" of the free radical type were formed on addition of 20, 50, 100, and 200 pM Cr(VI) to the A549 cells in suspension.Two other EPR "signals" with the characteristics of Cr(V) entities were seen at field values lower than the standard free radical value.Liver micro- somes from male Sprague-Dawley rats treated intraperitoneally with K2Cr2O7 (130 pmole/kg every 48 hr for six treatments) had decreased activity of cytochromes P4503A1 and/or 3A2, and 2C1 1. Hepatic microsomes from treated female Sprague-Dawley rats, in contrast, had increased activities of these isozymes.Lung microsomes from male Sprague-Dawley rats had increased activity of P4502C11.-Environ Health Perspect 102(Suppl 3):169-176 (1994).
Massachusetts Medical Society
Authors: John Figgis Jewett
Journal: New England Journal of Medicine (1956)

COMMITTEE ON MATERNAL WELFARESpontaneous Rupture of the UterusA thirty-six-year-old gravida 3, para 2, was admitted to the hospital in early active labor with intact membranes, apparently four weeks postmature by dates. Previous pregnancies and the current prenatal course had been absolutely normal. Admitted at about 8 p.m. with the presenting part above the spines, she began to have strong labor about midnight, when she received sedation and the cervix was found to be dilated 3 cm.; the presenting part had descended to the mid-pelvis. The position of the presenting part was indistinct in this station, but the patient . . .