tbuckley/cabot-search huggingface dataset:
State-Specific Cholesterol Screening Trends—United States, 1991-1999
Journal: JAMA (2000)

SICKLE CELL DISEASE (SCD) IS A COMmon single-gene disorder that affects three of every 1000 black newborns and approximately 50,000 persons in the United States. 1 Children affected with SCD are at increased risk for severe morbidity (e.g., severe hemolytic anemia, splenic dysfunction, pain crises, and bacterial infections) and mortality, especially during the first 3 years of life. 1,2In 1993, California, Illinois, and New York collectively accounted for approximately 20% of all births to blacks.All three states offer universal newborn screening for hemoglobinopathies.To assess the effectiveness of newborn screening programs for SCD and for receipt of and compliance with early medical interventions (e.g., penicillin prophylaxis and pneumococcal vaccination and other vaccination patterns), a 3-year collaborative follow-up study was conducted from 1995 through 1998 in California, Illinois, and New York. 3This report summarizes the results of this study, which demonstrate the difficulty in retrospectively finding children who were screened at birth so that data for evaluating program effectiveness can be assessed.The study comprised children born in 1992 and 1993 and in whom SCD was diagnosed during 1992-1993.Follow-up information about these children was ascertained through complementary surveys administered to parents and physicians of affected children.State health departments administered physician surveys, which were mailed to the child's last known provider.Parental sur-veys were administered by Battelle/ Survey Research Associates, Inc., which conducted telephone interviews and, along with the respective health departments, made repeated attempts to locate the children.During 1992-1993, SCD was diagnosed in 1042 children in California (265 cases), Illinois (254), and New York (523).Fourteen children (six in California, three in Illinois, and five in New York) died before the study began.Completed physician surveys were returned for 752 (72%) of the children (144 in California, 254 in Illinois, and 354 in New York).Parental surveys were completed for 252 (24%) children (87 in California, 52 in Illinois, and 113 in New York).When data from both surveys were merged, physician and parental surveys were completed for 184 (18%) children.Among physician respondents, 575 (76%) reported providing antibiotic (penicillin) prophylaxis to their SCD patients; 253 (44%) patients complied with the prophylaxis antibiotic regimen.One hundred eighty-nine (25%) patients received pneumococcal vaccine, and 179 (24%) received at least the first dose of Haemophilus influenzae type b vaccine (Hib).
Endothelium-derived Toll-like receptor-4 is the key molecule in LPS-induced neutrophil sequestration into lungs
Authors: G. Andonegui
Journal: Journal of Clinical Investigation (2003)

The authors inadvertently referred to the mice lacking the TLR4 gene obtained from The Jackson Laboratory as generated TLR4 knockout mice.These mice are the naturally occurring knockout or null mutant (TLR4LPS-del) mice from The Jackson Laboratory, which, nevertheless, lack the gene, message, and protein.
THE LAW DEMANDS SINCERITY.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A randomized, double-blind, placebo-controlled, first-in-human single ascending dose, multiple ascending dose, and food effect study to evaluate the safety, tolerability, and pharmacokinetic profile of FM101 in healthy volunteers
Authors: Seon-Ah Ha, Mi Ri Kim, Saehan Kang, Mira Yu, Chong-Woo Park, Jiyoun Lee, Jiyeon Kang, Ji-Young Kim, Seong Wook Seo, Seohyun Son, Hyeon Deok Cho, Hyuk Woo Lee, Lak Shin Jeong
Journal: Journal of Hepatology (2020)
Nosocomial Transmission of Multidrug-Resistant Tuberculosis Among HIV-Infected Persons— Florida and New York, 1988-1991
Journal: JAMA (1991)

During 1990 and 1991, outbreaks of multidrug-resistant tuberculosis (MDR-TB) in four hospitals (one in Miami and three in New York City) were investigated by CDC in collaboration with the reporting hospitals and state and local health departments. This report summarizes preliminary findings of the investigations and recommendations for prevention and control of MDR-TB outbreaks.
Core curriculum in allied health education
Authors: J. Hamburg
Journal: JAMA (1969)

In recent months the allied health professions have been enjoying a great deal of attention from educators interested in the development of a core curriculum. Although at one time or another almost every academic area has been a focus for similar interest, none can claim to be a more likely or persistent cynosure. What is there about these health related specialties which have made them so attractive a target for this activity? First, the very name allied health professions suggests that there exists among this diverse group a commonality of objectives as well as a sense of teamwork, and implicit in this is the likelihood that there is or should be a sharing of learning experiences. More important, however, is their sheer weight of numbers. No other group of health professionals augurs to grow as rapidly as this burgeoning collection of disciplines. Many of us concerned with the delivery of
VITAL STATISTICS.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Anesthesia
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Optotypes for Young Children
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Runaway pacemaker. A persisting problem
Authors: A. D. Bramowitz
Journal: JAMA (1974)

RECENT literature suggests that pacemaker tachycardia or "runaway" has become a rare problem. The phenomenon still occurs, however, and may be transient and difficult to document. <h3>Report of a Case</h3> An 85-year-old woman was brought to the emergency room after collapsing at home. She had had a Stanicor model 143 E7 ventricular inhibited pacer inserted transvenously at another hospital 261 days earlier for complete heart block with a slow ventricular rate. Her symptoms prior to the insertion were fatigue, lethargy, and syncope, as well as an episode of cerebral vascular insufficiency with transient left-sided weakness and dysarthria. She subsequently did well until the morning of admission, when she suddenly collapsed. In the emergency room the patient was unresponsive and apneic, and her blood pressure was unobtainable. An electrocardiogram demonstrated the pacemaker artifact at a variable rate between 300 to 375 beats per minute (Figure). There was no sign of ventricular
Peptic ulcer in myasthenia gravis
Authors: D. B. Sanders
Journal: JAMA (1969)

Gastric ulcers developed in four patients with myasthenia gravis while they were receiving therapy for their myasthenia. A conservative regimen healed the ulcers in two patients, and two required surgical procedures. A combination of etiologic factors seemed to be responsible for the development of ulceration in these patients. It is desirable to attempt a medical, rather than surgical, cure of the ulcers in such patients; however, if proper precautions are taken, complications of surgical treatment need not occur.
Diagnostic and Therapeutic Technology Assessment (DATTA)
Journal: JAMA (1983)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CSF Otorrhea
Authors: SALMA H. KHAN, TOMMY MAHONE, JOSEPH R. LOGIC
Journal: Clinical Nuclear Medicine (1994)

In-111 DTPA is a nondiffusable radiopharmaceutical, which, when introduced into the subarachnoid space, can be used to document flow patterns of cerebrospinal fluid (CSF) and also diagnose the site of CSF leakage with accurate localization. The authors describe a patient who developed drainage of clear fluid from the left external auditory canal, 1 month after left cochlear implant placement. The diagnosis of CSF otorrhea was easily confirmed by CSF cisternography.
A dynamic population model of disease progression in COPD
Authors: M, Hoogendoorn, M.P.M.H. Rutten-van Mölken, R.T. Hoogenveen, M.L.L. van Genugten, A.S. Buist, E.F.M. Wouters, T.L. Feenstra
Journal: European Respiratory Journal (2005)

To contribute to evidence-based policy making, a dynamic Dutch population model of chronic obstructive pulmonary disease (COPD) progression was developed. The model projects incidence, prevalence, mortality, progression and costs of diagnosed COPD by the Global Initiative for Chronic Obstructive Lung Disease-severity stage for 2000–2025, taking into account population dynamics and changes in smoking prevalence over time. It was estimated that of all diagnosed COPD patients in 2000, 27% had mild, 55% moderate, 15% severe and 3% very severe COPD. The severity distribution of COPD incidence was computed to be 40% mild, 55% moderate, 4% severe and 0.1% very severe COPD. Disease progression was modelled as decline in forced expiratory voume in one second (FEV<sub>1</sub>) % predicted depending on sex, age, smoking and FEV<sub>1</sub> % pred. The relative mortality risk of a 10-unit decrease in FEV<sub>1</sub> % pred was estimated at 1.2. Projections of current practice were compared with projections assuming that each year 25% of all COPD patients receive either minimal smoking cessation counselling or intensive counselling plus bupropion. In the projections of current practice, prevalence rates between 2000–2025 changed from 5.1 to 11 per 1,000 inhabitants for mild, 11 to 14 per 1,000 for moderate, 3.0 to 3.9 per 1,000 for severe and from 0.5 to 1.3 per 1,000 for very severe COPD. Costs per inhabitant increased from \#8364;1.40 to 3.10 for mild, \#8364;6.50 to 9.00 for moderate, \#8364;6.20 to 8.50 for severe and from \#8364;3.40 to 9.40 for very severe COPD (price level 2000). Both smoking cessation scenarios were cost-effective with minimal counselling generating net savings. In conclusion, the chronic obstructive pulmonary disease progression model is a useful instrument to give detailed information about the future burden of chronic obstructive pulmonary disease and to assess the long-term impact of interventions on this burden.
THE RESPONSIBILITY OF CZOLGOSZ.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CARBON MONOXIDE IN EVERYDAY LIFE
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Binding and internalization of transforming growth factor-β1 by human hepatoma cells: Evidence for receptor recycling
Authors: K Sathre
Journal: Hepatology (1991)

Cellular processing of 125I-labeled transforming growth factor-β1 was investigated in the human hepatoma cell lines Hep G2 and Hep 3B. Binding of 125I-transforming growth factor-β1 to cell surface receptors was specific, saturable and calciumindependent. Both cell lines exhibited a single class of high-affinity (Kd = 2.2 × 10−10 mol/L) binding sites (4.5 × 103 for the Hep G2 cell; 1.5 × 103 for the Hep 3B cell) for both human and porcine transforming growth factor-β1. Binding was temperature dependent, time dependent and pH dependent. Cell-bound 125I-transforming growth factor-β1 was removed by brief exposure to acidic medium (pH <4) but was converted into an acid-resistant state rapidly after shifting the cells to 37°C. Spontaneous dissociation of bound ligand over a 6 hr period at 4° C was less than 10%. Disuccinimidyl suberate was used to covalently label 125I-transforming growth factor-β1 to cell-surface binding sites. Labeling of the ligand/receptor complexes was inhibited by unlabeled transforming growth factor-β1 but was unaffected by other growth factors. The radiolabeled complexes showed approximate molecular weights of 280,000, 85,000 and 65,000 when run on reducing sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Cell-bound 125I-transforming growth factor-β1 was internalized and degraded at 37° C, and the products were released into the medium as trichloroacetic acid-nonprecipitable radioactivity. The lysosomotropic base chloroquine and the carboxylic ionophore monensin inhibited degradation and release of 125I-labeled products from the cells. In the presence of cycloheximide and under conditions of sustained binding and uptake of saturating amounts of 125I-transforming growth factor-β1 for 3 hr, a 20% decrease in the binding capacity of Hep G2 cells occurred. The result indicates that during active processing of the 125I-transforming growth factor-β1 receptor complex by Hep G2 cells, surface receptors for transforming growth factor-β1 are replenished either from a cryptic intracellular pool or by receptor recycling. (HEPATOLOGY 1991;14:287–295.)
Prophylaxie de la tuberculose: Applications en Europe
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Plutonium problems.
Journal: Environmental Health Perspectives (1994)

whole looks like from a slice."Bromberg said that when the model is further advanced, it will offer his center, and others, chances to collaborate."We work to understand how human cells react to toxici- ty.That's an important piece of the picture of lung function we all are trying to reach." Contaminants in FishFrom the icy waters of Boston Harbor to the warm waves of San Diego Bay, bottom- dwelling fish suffer liver damage caused by chemical contaminants, according to researchers at the National Oceanic and Atmospheric Administration.But seafood lovers need not panic, because damaged specimens were captured primarily in urban waters where commercial fishing is prohibited, said Lyndal L.
THE CAUSE OF SYPHILIS.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal