tbuckley/cabot-search huggingface dataset:
Compartmentalization of TNF Receptor 1 SignalingInternalized TNF Receptosomes as Death Signaling Vesicles
Authors: W SCHNEIDERBRACHERT, V TCHIKOV, J NEUMEYER, M JAKOB, S WINOTOMORBACH, J HELDFEINDT, M HEINRICH, O MERKEL, M EHRENSCHWENDER, D ADAM
Journal: Immunity (2004)
Codanin-1 Mutations In Congenital Dyserythropoietic Anemia Type 1 Affect HP1α Localization In Erythroblasts
Authors: Raffaele Renella, Nigel Roberts, Jill M Brown, Marco De Gobbi, Louise Bird, Tasneem Hassanali, Jacqueline Sloane-Stanley, Jacqueline A Sharpe, Jacqueline Loelia Cordell, David J.P. Ferguson, Veronica Buckle, Douglas R. Higgs, William G Wood
Journal: Blood (2010)
Hand Surgery
Authors: Vijay S. Gorantla
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Listening to a different drummer
Authors: L. S. King
Journal: JAMA (1989)

IN 1928, when I entered medical school, my role model was William James. He had taken a medical degree, and then, without ever having practiced, devoted himself to psychology, and finally to philosophy. Such a career sequence seemed admirable to an undergraduate who had majored in philosophy and psychology in college, and the exploration of that path was attractive. I was no stranger to a life in medicine, for my father was a general practitioner, and an older brother had preceded me to medical school. The first 2 years, everyone had said, could be quite dull and disagreeable, and I gritted my teeth for that first rite of passage, the course in anatomy. <h3>The First 2 Years</h3> This course, which included embryology and a few lectures on medical history, was indeed dull. However, within the first 2 months I had an illumination. A surprise examination caught me unprepared, and some
Vertebral Sarcoidosis
Authors: Julio E. Goobar
Journal: JAMA (1961)

SARCOIDOSIS is a protean disease characterized pathologically by the formation of noncaseating granulomas. While involvement of virtually every tissue and organ has been described, the usual sites are lymph nodes, liver, spleen, lungs, skin, and the uveoparotid region. The exact incidence of bone marrow involvement is not known, but osseous lesions are identified in about 20 per cent of the cases, nearly always limited to the small, long bones of the hands and feet. The discrete, eccentric, lytic lesions in these bones are characteristic and when present are important diagnostic features. Involvement of other bones is distinctly unusual. Only 2 documented examples of vertebral involvement were found in a search of the literature.<sup>1, 2</sup> <h3>Report of a Case</h3> A 35-year-old female was well until November of 1959, when she developed episodes of severe, stabbing pain in the neck. These episodes lasted up to an hour and recurred several
Scientific misconduct. New definition, procedures, and office--perhaps a new leaf
Authors: D. Rennie
Journal: JAMA (1993)

The good behavior of scientists might seem remote from the concerns of the physician. But the practice of medicine is based on science, which means that it is grounded on the integrity of the biomedical research community. For that reason alone, the matter would deserve our attention, but in addition, many scientists have medical degrees. We expect those scientist-physicians to share the high standards of the medical profession, and when they do not, the profession is damaged in the eyes of the public. Finally, if medical editors unwittingly publish fraudulent work in journals, as happens from time to time, reputations are tarnished. It is for these reasons that we are all involved in the debate over what has come to be called "scientific misconduct," and why<i>JAMA</i>is publishing the article by Dresser in this issue.<sup>1</sup> Few medical articles are so uniquely important that patients would suffer were the
Evergreen
Authors: Alex Sievert
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Book Review Surgical Diagnosis in Tabular Outline . A. J. Cemach, Vienna. Translated with Addition and Notes by Eduard L. Bortz and an Introductory Note by John B. Deaver. 109 Tabular Forms and 129 Plates, with 548 Subjects, many in colors. 1928. F. A. Davis Company, Philadelphia.
Journal: New England Journal of Medicine (1928)
Stat Bite Cigarette Consumption and Taxation in California
Journal: JNCI Journal of the National Cancer Institute (1993)

Journal Article Stat Bite Cigarette Consumption and Taxation in California Get access JNCI: Journal of the National Cancer Institute, Volume 85, Issue 18, 15 September 1993, Pages 1452–1453, https://doi.org/10.1093/jnci/85.18.1452 Published: 15 September 1993
Thrombolytic Therapy: Current Status
Authors: Victor J. Marder, Sol Sherry
Journal: New England Journal of Medicine (1988)

Therapeutic IssuesRegionalization of TherapyThe possibility of increasing thrombolysis without causing bleeding has motivated efforts to direct therapy selectively to the pathologic thrombus. Two approaches that have been tried are administration of agents that may bind selectively to a thrombus, and regional infusion of agents into the occluded vessel in order to restrict therapy anatomically to the thrombus. Both methods have theoretical advantages, but experience has revealed practical problems with each technique.The concept that the effects of thrombolytic therapy on the coagulation mechanism initiate bleeding provided the rationale for the use of fibrin-selective agents, each of which exploits . . .
Serotonin Transporter Polymorphisms and Persistent, Pervasive Childhood Aggression
Authors: Joseph Beitchman
Journal: American Journal of Psychiatry (2006)

Objective: The purpose of this study was to examine the potential association of the serotonin transporter (5-HTT) gene and childhood aggression by testing the 5-HTT variable-number-tandem-repeat and serotonin transporter promoter polymorphism (5-HTTLPR), including the recently discovered Lg allelic variant of 5-HTTLPR. Method: Clinically referred children displaying extreme aggression, with a minimum 2-year history, were genotyped for 5-HTTLPR (N=77) and 5-HTT variable-number-tandem-repeat (N=78). Analyses compared genotype frequencies of the agressive children with healthy comparison subjects. Results: The “low expressing” genotypic variants of the 5-HTTLPR polymorphism (S/S, Lg/S, Lg/Lg) were significantly associated with childhood aggression. Conclusions: This is the first study to report a significant association between the 5-HTTLPR gene and childhood aggression.
Is Dyslexia a Disease?
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A STORY OF CHICKAMAUGA.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MENTAL CONTAGION.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Spectinomycin-resistant Neisseria gonorrhoeae
Authors: C. Thornsberry
Journal: JAMA (1977)

<i>Neisseria gonorrhoeae</i>resistant to high levels of spectinomycin (more than 2,048 μg/ml), were isolated from specimens obtained from a patient with urethritis. The bacterial resistance to spectinomycin is probably due to ribosomal changes that are a result of a chromosomal mutation. If spectinomycin fails to cure gonorrhea, spectinomycin resistance should be considered. (<i>JAMA</i>237:2405-2406, 1977)
Release of serine/threonine-phosphorylated adaptors from signaling microclusters down-regulates T cell activation
Authors: Rémi Lasserre, Céline Cuche, Ronnie Blecher-Gonen, Evgeny Libman, Elise Biquand, Anne Danckaert, Deborah Yablonski, Andrés Alcover, Vincenzo Di Bartolo
Journal: The Journal of Experimental Medicine (2011)
Physical Therapy and Exercise for Knee Arthritis
Journal: Annals of Internal Medicine (2000)

Summaries for Patients1 February 2000Physical Therapy and Exercise for Knee ArthritisSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-3-200002010-00028 SectionsAboutFull Text ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Osteoarthritis is the most common type of arthritis. One third of people between the ages of 63 and 94 have osteoarthritis in their knees that can be painful and may limit their ability to get up from a chair, stand, walk, or climb stairs. Treating ostearthritis with drugs does not always work well and often leads to drug-related side effects. There is some evidence that physical therapy and exercise helps people with osteoarthritis.Why did the researchers do this particular study?The researchers wanted to see whether specially ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Effectiveness of Manual Physical Therapy and Exercise in Osteoarthritis of the Knee. A Randomized, Controlled Trial.” It is in the 1 February 1999 issue of Annals of Internal Medicine (volume 132, pages 173-181). The authors are G.D. Deyle, N.E. Henderson, R.L. Matekel, M.G. Ryder, M.B. Garber, and S.C. Allison.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoEffectiveness of Manual Physical Therapy and Exercise in Osteoarthritis of the Knee Gail D. Deyle , Nancy E. Henderson , Robert L. Matekel , Michael G. Ryder , Matthew B. Garber , and Stephen C. Allison Metrics 1 February 2000Volume 132, Issue 3Page: 173KeywordsAdverse reactionsArthritisExerciseExercise therapyKneesOsteoarthritisSports and exercise medicineStiffnessSurgeryUltrasound imaging Issue Published: 1 February 2000 CopyrightCopyright © 2000 by American College of Physicians. All Rights Reserved.Loading ...
The use of iodine as a thyroidal blocking agent in the event of a reactor accident. Report of the Environmental Hazards Committee of the American Thyroid Association
Authors: D. V. Becker
Journal: JAMA (1984)

In the event of a nuclear reactor accident, radioactive materials could be released into the environment: radioisotopes of iodine could constitute a major component of such a release. Upon such exposure, radioiodines could enter the body and accumulate in an unprotected thyroid gland where they would remain for varying periods of time. A number of methods have been proposed to protect those at risk of exposure. Administration of thyroidblocking agents (such as potassium iodide) to exposed populations could be effective, but their use has raised a number of questions since there are considerable gaps in the scientific information available about the possible effects of low-level radiation from radioiodine. In addition, there are only limited data available about potential toxic side effects of potassium iodide distributed widely to large, unsupervised populations. Concern about these issues led the American Thyroid Association to appoint a committee of its members with special interest and competence in these areas to review the problems in detail and develop an advisory statement on the questions at issue for those to whom this matter might be of concern. (<i>JAMA</i>1984;252:659-661)
Abstract 2187: The Balance Of Pro-inflammatory And Ant-inflammatory Circulating Cytokine mRNA Gene Expression In CHF Patients With And Without Cachexia Compared To Healthy Control Subjects.
Authors: Anja Sandek, Joe Wüst, Juergen Bauditz, Stephan von Haehling, Alexander Swidsinski, Wolfram Doehner, Mathias Rauchhaus, Herbert Lochs, Hans D Volk, Stefan D Anker
Journal: Circulation (2007)

Background: Chronic heart failure (CHF) is a state of chronic inflammation. High serum levels of TNF alpha and the presence of cardiac cachexia are known to predict poor survival in CHF. Abnormal balance of pro- and anti-inflammatory circulating cytokine mRNA gene expression is thought to contribute to cachexia in humans, but has never been studied in CHF patients. Methods and Results: We studied 7 patients with cardiac cachexia (age 70±4 years, LVEF 28±2%, peak VO2 12.7±1.6 mL/kg/min, all &gt;6% weight loss in previous 6–24 months), 19 noncachectic CHF patients (age 68±2 years, LVEF 31±2%, peak VO2 14.7±1.1 mL/kg/min) and 17 control subjects of similar age and gender (peak VO2 25.1±1.7 mL/kg/min, LVEF 71±2%). The mRNA gene expression of circulating mononuclear blood cells for pro-inflammatory mediators that have been implicated in the wasting process of ageing (TNF, STAT-1, STAT-3, SOCS-1 and SOCS-3) as well as anti-inflammatory cytokines (IL-10, tumor growth factor (TGF) beta were investigated by real time polymerase chain reaction. Values for the house keeping gene and genes of interest were calculated from double determinations within 40 cycles. We found higher TNF expression in cachectic compared to noncachectic CHF patients (log mean −0.5±0.17 vs. −1.2±0.12, p=0.002, ANOVA-p=0.0071) and control subjects (log mean −1.2±0.1, p=0.006). In contrast, there was no change in IL-10 gene expression in cachectic patients compared to noncachectic patients and controls (log mean −2.6±0.2 vs. −3.0±0.09 vs. −2.9±0.1, all p&gt;0.13). Consequently TNF/IL-10 expression ratio was highest in cachectic patients (308±138 vs. 132±55 in noncachectic CHF patients vs. 101±37 in controls, p&lt;0.004). There were no differences in gene expression of STAT-1, STAT-3, SOCS-1, SOCS-3 between cachectic and noncachectic individuals (all p&gt;0.17). Similarly, no differences were found for gene expression of TGF beta (p&gt;0.15). Conclusion: The balance between the pro-inflammatory cytokine TNF and the anti-inflammatory cytokine IL-10 on the level of mRNA expression of circulating mononuclear cells is significantly disturbed. Proinflammatory cytokine imbalance in cardiac cachexia may be important for the pathophysiology of body wasting and may represent the activated immune reflex.
Clinical and laboratory features of murine typhus in south Texas, 1980 through 1987
Authors: J. S. Dumler
Journal: JAMA (1991)

<h3>Objective.</h3> —The clinical and laboratory features of patients with murine typhus have not been extensively reviewed since 1946. We have updated these findings in patients from south Texas who were examined by modern clinical and laboratory methods from 1980 through 1987. <h3>Design.</h3> —Patients were identified by serological methods in this case series, and clinical, epidemiologic, laboratory, and therapeutic data were compiled and analyzed. <h3>Setting.</h3> —The majority of patients (77 of 80) were identified in a primary care community hospital setting; the remainder (3 of 80) were ambulatory hospital outpatients. <h3>Patients.</h3> —From 1980 through 1987, a total of 345 patients were diagnosed with murine typhus; 90 of these patients were seen at four hospitals in south Texas; of these, 80 had clinical and laboratory data available for review. <h3>Main Outcome Measures.</h3> —The frequency of common clinical manifestations (eg, headache, fever, and rash) and laboratory findings (eg, leukocyte and platelet counts and serum chemistry abnormalities) of patients with infectious diseases was tabulated. Clinical severity was semiquantitatively assessed and was correlated with clinical, laboratory, and therapeutic results. <h3>Results.</h3> —Most cases (69%) occurred from April through August. Rash occurred in 54%; the triad of fever, headache, and rash was observed in only 12.5% of patients when first examined by a physician; respiratory and gastrointestinal symptoms were also frequent. Multiple organ involvement was documented by frequent abnormal laboratory findings of the hematologic, respiratory, hepatic, and renal systems. Disease severity was related to older patient age, the presence of renal dysfunction, leukocytosis, and hypoalbuminemia, and previous therapy with sulfa antibiotics. <h3>Conclusions.</h3> —Infection by<i>Rickettsia typhi</i>causes a systemic illness with clinical and laboratory abnormalities not previously recognized or described. Early clinical diagnosis and treatment are needed to avoid undue morbidity and mortality. (<i>JAMA</i>. 1991;266:1365-1370)