tbuckley/cabot-search huggingface dataset:
DOMESTIC CORRESPONDENCE.
Authors: Wm. C. Dabney
Journal: JAMA (1884)

To the Editor of the Journal of the American Medical Association: In theJournalfor February 16, 1884, there is an editorial on the subject of the new medical law of Virginia. The writer of the editorial says that one of the "legitimate objects to be accomplished by legislative enactments for regulating the education and practice of the medical profession, should consist of a simple provision by which the certificates of similar bodies in other States should be recognized, so as to maintain a comity of rights and interests between the States." That such a recognition of the certificates issued by the Board of one State by the Board of another would be very desirable, there can be no question; but so long as the Boards differ so widely in their requirements as they now do, I do not see how such recognition could be made. For example, in many
Negative Studies
Authors: Marcia Angell
Journal: New England Journal of Medicine (1989)

In this issue of the Journal is a report of a study showing that if women take vitamins around the time of conception, it has no effect on the incidence of neural-tube defects in the newborn.1 This is a large, carefully designed and analyzed case–control study with negative results — that is, the exposure, in this case vitamins, was not found to be effective. The results are in contrast to those of earlier studies that did find an association between vitamin use in pregnant women and a lower incidence of neural-tube defects in their offspring.2 3 4 5 It is widely believed that . . .
The deubiquitinase USP44 is a tumor suppressor that protects against chromosome missegregation
Authors: Andrew J. Holland, Don W. Cleveland
Journal: Journal of Clinical Investigation (2012)

The mitotic checkpoint plays an important role in preventing chromosome segregation errors and the production of aneuploid progeny. In this issue, Zhang et al. examine mice and cells lacking the deubiquitinating enzyme USP44. Surprisingly, they find that USP44 prevents chromosome segregation errors through a function independent of its previously identified role in the mitotic checkpoint. Usp44-null animals develop aneuploidy and experience increased rates of tumorigenesis, implicating USP44 as novel tumor suppressor.
人体测量因素和Breslow厚度
Authors: J.S. Stenehjem, M.B. Veierød, L.T. Nilsen, R. Ghiasvand, B. Johnsen, T.K. Grimsrud, R. Babigumira, N.C. Støer, J.R. Rees, T.E. Robsahm
Journal: British Journal of Dermatology (2018)

黑色素瘤是挪威增长最快的癌症;2016年,2114名男性和女性被诊断为患该疾病。这种癌症通常能够在早期确诊,如果您密切关注皮肤的变化,将能够在早期检测出癌症。但是,转移性黑色素瘤(扩散到身体的其他部位)是一种难以治愈的严重疾病,挪威每年有超过300人死于黑色素瘤。肿瘤厚度(称为Breslow厚度)是患上黑色素瘤后能否存活的重要因素;诊断时肿瘤较薄的患者会比肿瘤较厚的患者生存时间更长。在挪威的一项新研究中,研究人员探索了某些因素(称为人体测量因素‐比如身体质量指数(BMI)、人体皮肤表面积(BSA)、身高、体重和体重变化)与Breslow厚度的整体关联,并按照解剖部位及组织学亚型(黑色素瘤类型)进行了分析。入选研究组(被称为基于Janus人口的1972–2003年群体)的近30万挪威男性和女性参加了黑色素瘤随访。到2014年,研究人员确定了2570例黑色素瘤的肿瘤厚度信息。这个大型黑色素瘤病例分析表明,BMI、BSA、体重和Breslow厚度之间存在正相关,这表明Breslow厚度随着BMI、BSA和体重的增加而增加,然后在达到最高值后趋于平稳或下降,这表示在最高值时出现行为或其他机制。
Relation of insulin resistance and body size in adolescence to birthweight
Authors: Maureen A Murtaugh, David R Jacobs, Kathryn H Schmitz, Antionnette Moran, Julia Steinberger, Alan R. Sinaiko
Journal: Circulation (2001)

P04 A relationship between birthweight (BW) and the insulin resistance syndrome has been reported in adults but has not been defined in adolescents. Data were analyzed in 287 children (124 girls, 163 boys) mean age 15.0 ±1.2 yrs undergoing euglycemic insulin clamp studies (intravenous administration of 1mU/kg/min of insulin balanced by a variable infusion of 20% glucose to maintain blood glucose at 100 mg/dl). Insulin sensitivity (M) was determined by glucose uptake during the final 40 minutes of the 3 hr clamp per kg body weight. BW was reported by parents. BW ranged from 1021-4848g (mean, 3403 ±573), with 5.4% of BW &lt; 2500g. Height increased with BW (r=0.3, p&lt;0.0001). Fat mass and BMI had U-shaped relations with BW after adjustment for ethnicity, age, sex, and blood pressure, but lean body mass was not signficantly different between BW quartiles ( Table). Fasting insulin was positively, and M inversely, related to fat mass (r=0.55,and r=-0.45 respectively p&lt;0.0001). After further adjustment for body weight, fasting insulin was highest (p= 0.009) and M lowest (p=0.17) in the lowest BW quartile. Triglycerides, HDL-C, LDL-C and blood pressure were unrelated to BW. In these data, insulin resistance in adolescence is higher with low BW and increased body fat. In addition, fat mass is increased in both high and low BW in adolescence. Thus both high and low BW are potential risk factors for the development of adult cardiovascular disease and insulin resistance syndrome. Table 1.
MEXICO CITY
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ANGINA PECTORIS OF DIABETES
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Elective stenting of unprotected left main coronary artery stenosis: Intravascular ultrasound guidance and debulking atherectomy before stenting Seung-Jung Park, Seong-Wook Park, Cheol Whan Lee, Myeong-Ki Hong, Jae-Joong Kim. Asan Medical Center, Seoul, South Korea
Journal: Journal of the American College of Cardiology (2001)
NEW FACTS ABOUT SALICYLATES
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reactive Plasmacytoses Are Expansions of Plasmablasts Retaining the Capacity to Differentiate Into Plasma Cells
Authors: Gaëtan Jego, Nelly Robillard, Denis Puthier, Martine Amiot, Françoise Accard, Danielle Pineau, Jean-Luc Harousseau, Régis Bataille, Catherine Pellat-Deceunynck
Journal: Blood (1999)
George Cheyne (1671-1743), master of style
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Combined exposure to ozone and nitrogen dioxide.
Authors: B D Goldstein
Journal: Environmental Health Perspectives (1976)

The combined effects of ozone and nitrogen dioxide were assessed in an in vitro test system utilizing human red cells. In general, these two pollutants had additive effects on the parameters measured which included osmotic fragility, acetylcholinesterase activity, lipid peroxidation, reduced glutathione and methemoglobin levels. However, at lower pollutant doses a synergistic increase in lipid peroxides was noted while at higher doses the effect became less than additive. Further studies of this observation suggested that ferrous hemoglobin potentiates ozone-induced lipid peroxidation while methemoglobin, resulting primarily from nitrogen dioxide, inhibits this process. Ozone was also found to potentiate the methemoglobinemic effects of nitrogen dioxide, particularly in sequential studies in which ozone exposure preceded nitrogen dioxide. Inasmuch as the effects of these two pollutants vary from protective to synergistic depending on the pollutant concentration, duration and sequence of exposure, as well as on the parameter assayed, it would appear that the approach to in vivo study of the combined effects of ozone and nitrogen dioxide should be aimed at simulating ambient conditions as closely as possible.
Journal of Investigative Dermatology, Baltimore
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
State-Specific Prevalence of Obesity Among Adults—United States, 2005
Journal: JAMA (2006)

Obesity, one of the 10 leading U.S. health indicators, is associated with increased risk for hypertension, dyslipidemia, type 2 diabetes, coronary heart disease, stroke, and certain cancers. A Healthy People 2010 objective is to reduce to 15% the prevalence of obesity among adults in the United States (objective 19-2). Both national-level data from the National Health and Nutrition Examination Survey (NHANES) and state-level data from the Behavioral Risk Factor Surveillance System (BRFSS) indicate that the prevalence of obesity among adults continued to increase during the past decade. In 2003, one study estimated that state-specific, obesity-attributable medical expenditures ranged from $87 million in Wyoming to $7.7 billion in California. To assess the prevalence of obesity among adults by state and demographic characteristics since 1995, data were analyzed from the 1995, 2000, and 2005 BRFSS surveys. The results of these analyses indicated that 23.9% of U.S. adults were obese in 2005, and the prevalence of obesity increased during 1995-2005 in all states. To reverse this trend, a sustained and effective public health response is needed, including surveillance, research, policies, and programs directed at improving environmental factors, increasing awareness, and changing behaviors to increase physical activity and decrease calorie intake.
Bacteriaemia
Authors: E. J. Stokes
Journal: BMJ (1954)

<h3>Background</h3> Monitoring of contamination with cytostatics has been required by law in our country for several years. However, it was put into practice thanks to the CYTO project that was managed by our pharmacy in 2006–2010. <h3>Purpose</h3> The use of cytostatic drugs has been rising in our country. While in 2010 our pharmacy compounded 23 000 bags and syringes, this amounted to 38 000 in 2015. Therefore, regular monitoring of contamination at all work sites involved in compounding or administration is important. The level of contamination should be monitored both in the pharmacy and in the wards. Since 2007, measurement of cyclophosphamide (CP) and platinum cytostatic (Pt) contamination has been available. Since 2015, measurement of 5-fluorouracil (FU) has been also possible. These drugs belong to the most frequently used cytostatics (together they represent 49.0% of compounded units). <h3>Material and methods</h3> Sampling of surfaces is performed with unwoven textile moistened by acetate buffer. CP and FU were analysed by high performance liquid chromatography (Waters UPLC Aquity with Xevo TQ-S Agilent mass detector), and Pt were analysed by mass spectrometry with inductively coupled plasma (Agilent I CP-MS 7500). <h3>Results</h3> Higher contamination was generally found in hospital wards and compounding units. Maximal detected levels of FU on floors: hospitals, 775 pg/cm<sup>2</sup> (median 189.7 pg/cm<sup>2</sup>); pharmacies, compounding units, 564 pg/cm<sup>2</sup> (median 3.6 pg/cm<sup>2</sup>); and pharmacies, storage rooms, 25 pg/cm<sup>2</sup> (median &lt;7 pg/cm<sup>2</sup>). Maximal detected levels of CP on floors: hospitals, 3244 pg/cm<sup>2</sup> (median 101.9 pg/cm<sup>2</sup>); pharmacies, compounding units, 638 pg/cm<sup>2</sup> (median 5.8 pg/cm<sup>2</sup>); and pharmacies, storage rooms, 235 pg/cm<sup>2</sup> (median &lt;1 pg/cm<sup>2</sup>). Maximal detected levels of Pt on floors: hospitals, 5390 pg/cm<sup>2</sup> (median 47 pg/cm<sup>2</sup>); pharmacies, compounding units, 84 pg/cm<sup>2</sup> (median 0.9 pg/cm<sup>2</sup>); and pharmacies, storage rooms, 57 pg/cm2 (median &lt;0.2 pg/cm<sup>2</sup>). <h3>Conclusion</h3> Measurement of contamination raised information about the level of health risk of healthcare personnel handling cytostatics (pharmacists and nurses). Hospital pharmacists can reduce contamination on their work sites and they should co-operate with wards. Preventive measures that are able to decrease contamination in wards include branched infusion lines, wall connected infusion poles instead of stands, and self-cleaning toilet seats. <h3>References and/or acknowledgements</h3> We thank all participating hospitals. No conflict of interest
The use of Part I National Board scores in the selection of residents in ophthalmology and otolaryngology
Authors: R. J. McCollister
Journal: JAMA (1988)

A survey of ophthalmology and otolaryngology residency program directors was conducted to determine the extent to which National Board of Medical Examiners (NBME) Part I scores are used in selection of residents in these highly competitive specialty fields. Results from 218 completed questionnaires representing nearly 90% of all US ophthalmology and otolaryngology/head and neck surgery programs were analyzed. More than three fourths indicated that Part I NBME scores were used in selecting residents; more than half of the programs used these scores as a means to determine whom to interview. The direct use of NBME scores in the residency application process is widespread; however, such use of NBME scores is not consistent with the purposes of the National Board. The preeminent role of the faculty in the evaluation of medical students and in the assessment of their clinical competence needs emphasis. (<i>JAMA</i>1988;259:240-242)
Evaluation of Measles Immunization Methods
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MAST Suits
Authors: P. Kent Harman
Journal: JAMA (1985)

<h3>To the Editor.—</h3> The article by Kaback et al<sup>1</sup>regarding use of the MAST suit is comprehensive. The general assumption that application of the MAST garment does not impair renal function is probably erroneous. Shenasky and Gillenwater<sup>2</sup>demonstrated that up to 80% of the pressure exerted by MAST suits fitted to dogs is transmitted to the abdomen and retroperitoneum. We have shown in a dog model that elevating intraabdominal pressure to 20 mm Hg reduced renal blood flow and glomerular filtration rate to 23% and 21% of normal, respectively.<sup>3</sup>In humans, we have shown that renal function is dramatically impaired when the intra-abdominal pressure exceeds 30 mm Hg.<sup>4</sup> Clearly, it has been well demonstrated both in the laboratory and in clinical settings that the kidneys are exquisitely sensitive to external compression. It appears from our work that application of the abdominal portion of the MAST suit
Abstracts: Part IV
Authors: M Van Milligen De Wit, S Van Deventer, J Van Bracht, E Rauws, K Huibregtse, G Tytgat, A Van Berkel, J Bergman, I Waxman, P Andres, H Queiroz, G Macedo, J Pires, P Figueira, M Conde, L Carvalho, R Silva, C Salgado, R Figueira, A Chaves, T Pinto, J Monteiro, F Seixas, B Peteira, A Carvalho
Journal: Gut (1995)

4th UEGWBerlin 1995 cle (SMA), anti-nuclear (ANA), and perinuclear antineutrophil cytoplasmic (p- ANCA) autoantibodies.We determined the prevalence and relation of these non-organ specific autoantibodies in PSC pts with or without associated IBD.We also looked for a possible association of p-ANCA and the HLA DRw52a allele (DR52a).Patients: In 63 pts (22 F/41 M), with a mean age of 44 (17-78) yrs, PSC was present for a mean of 6 (1-26) yrs and 40 pts (64%) had asso- ciated IBD (29 UC, 11 CD) for a mean of 12 (1-35) yrs.Methods: Sera from 63 PSC pts (23 PSC, 29 PSC/UC, 11 PSC/CD) were analysed for ANA (Hep 2), SMA and anti-mitochondrial (AMA) autoantibodies (indirect immunofluorescence (IIF): positive (pos.)titre > 1:20), and p-ANCA (IIF on ethanol-fixed neu- trophils: pos.titre 1:16; ELISA: anti-MPO/PR3/Elastase).ANA pos.pts were also tested for anti-dsDNA.DR52a status was assessed in 60 pts with molecular DNA typing technics.Results: p-ANCA IIF was pos. in 46/63 pts (73%): 16/23 (70%) PSC. 24/29 (83%) PSC/UC, and 6/11 (55%) PSC/CD pts.p-ANCA ELISA anti-MPO/PR3/Elastase was negative in all pts.AMA was not present in serum of any of the pts.ANA was pos. in 8/63 pts (13%).Anti-dsDNA was negative in all ANA pos.pts.SMA was pos. in 10/63 pts (16%).ANA and SMA were exclusively present in p-ANCA pos.pts.DR52a was pos. in 28/60 (47%) pts: 23/42 (55%) of p-ANCA pos.vs 5/18 (28%) of p-ANCA negative pts.Conclusion: The prevalence of p-ANCA and DR52a in this Dutch group of PSC pts confirms the results of previous studies in European and American pts.However, the demonstrated prevalence of p-ANCA in PSC/CD pts was not established reliably before.ANA and SMA were exclusively present in the p-ANCA pos.pts, suggesting a hitherto unknown association between these non-organ specific autoantibodies in PSC.DR52a was associated with p-ANCA status, suggesting p-ANCA to be a subclinical marker of genetic heterogeneity in PSC pts.