tbuckley/cabot-search huggingface dataset:
Death from weight-control pills. A case report with objective postmortem confirmation
Authors: R. W. Jelliffe
Journal: JAMA (1969)

Weakness, vomiting, severe hypokalemia, and cardiac arrhythmias developed in an obese 19-year-old boy on a weight-reduction regimen of thyroid preparations, digitalis, amphetamines, and diuretics. The patient died despite attempts to replace potassium, cardioversion, and cardiac massage. Protein-bound iodine and serum uric acid levels were elevated. Autopsy revealed no other cause of death. Results of postmortem chemical studies revealed digitalis in the myocardium and amphetamine in the liver. Death is believed to have been due to the combined effect of weight-control medications causing myocardial irritability, cardiac arrhythmias, and hypokalemia. Obesity alone is not a valid indication for large doses of thyroid preparations, for digitalis, or for prolonged fluid depletion by long-term diuretic administration.
PREGNANCY IN THE RUDIMENTARY HORN OF A BICORNATE UTERUS
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hyperthyroidism
Authors: Brian J. Bohlmann
Journal: Annals of Internal Medicine (1995)

Letters1 March 1995HyperthyroidismBrian J. BohlmannBrian J. BohlmannSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-122-5-199503010-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:A review article on hyperthyroid disease [1] described immune-mediated leukopenia associated with Graves disease. I describe a patient with thrombocytopenia that complicated Graves disease.A 24-year-old pregnant Hispanic woman had Graves disease at 14 weeks gestation and was treated with propylthiouracil. Three weeks later, a routine complete blood count showed a platelet count of 20 000 cells/mm3. Examination of a bone marrow biopsy specimen showed increased megakaryocytes, and platelet-associated IgG and IgM antibodies were elevated. She was treated successfully with prednisone, 100 mg daily.In one series [2], five patients with Graves disease and thrombocytopenia were described. ...References1. Klein I, Becker D, Levey G. Treatment of hyperthyroid disease. Ann Intern Med. 1994; 121:281-8. Google Scholar2. Adrouny A, Sandler RM, Carmel R. Variable presentation of thrombocytopenia in Graves disease. Arch Intern Med. 1982; 142:1460-4. Google Scholar3. Lamberg BA, Kivikangas V, Pelkonen R. Thrombocytopenia and decreased life-span of thrombocytes in hyperthyroidism. Ann Clinic Res. 1971; 3:98-102. Google Scholar4. Kurata Y, Nishioeda Y, Tsubakio T. Thrombocytopenia in Graves disease: effect of T3 on platelet kinetics. Acta Haemotol. 1980; 63:185-90. Google Scholar5. Marshall JS, Weisberger AS, Levy RP. Coexistent idiopathic thrombocytopenic purpura and hyperthyroidism. Ann Intern Med. 1967; 67:411-4. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1995Volume 122, Issue 5Page: 393-394KeywordsAntibodiesComplete blood countHispanic peopleHyperthyroidismIdiopathic thrombocytopenic purpuraMegakaryocytesPlateletsPregnancyThyroidThyroid-stimulating hormone ePublished: 15 August 2000 Issue Published: 1 March 1995 Copyright & PermissionsCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Correction
Journal: BMJ (1956)

186~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~EIA JAN.U2 It is claimed2 that 75%O or more of persistent enuretics are cured by this treatment, but it is extremely difficult to assess the long-term results.It is a method worth trying in an older child, in whom other methods have failed, and in whom organic lesions have been excluded.It is not a very practical form of treatment for use in the management of enuresis in general, and one defect is that a satisfactory and durable form of electrode has not yet been perfected.
Internalizing Behaviors in 4-Year-Old Children Exposed in Utero to Psychotropic Medications
Authors: Shaila Misri, Pratibha Reebye, Kristin Kendrick, Diana Carter, Deirdre Ryan, Ruth E. Grunau, Tim F. Oberlander
Journal: American Journal of Psychiatry (2006)

Objective: Internalizing behaviors in children between 4 and 5 years of age who had been prenatally exposed to psychotropic medications were investigated. The authors had previously reported the effects of prenatal medication exposure in this same cohort when they were newborns and infants at 3 and 8 months of age. Method: Parental/teacher reports and a clinical measure of mother and child interactions were used to assess levels of internalizing behaviors (e.g., depression, anxiety, withdrawal). Outcomes were compared between children with prenatal selective serotonin reuptake inhibitor (SSRI) exposure (N=22) and nonexposed children of healthy, nondepressed, nonmedicated mothers (N=14). Measures of maternal mood were obtained. Ordered logistic regressions, independent-sample t tests, and univariate ANOVAs were used to compare outcomes between groups. Pearson correlations were used to determine associations between maternal mood and child behaviors. Results: Levels of internalizing behaviors did not differ significantly between children with prenatal psychotropic medication exposure and those not exposed. However, as symptoms of maternal anxiety and depression increased, so did reported internalizing behaviors in their children. Conclusions: Prenatal exposure to psychotropic medications was not associated with increased reports of internalizing behaviors at 4 years of age, whereas impaired maternal mood did have an identified impact on child behavior. Further study of complex associations between maternal psychiatric disorders, prenatal SSRI exposure, and childhood internalizing behaviors is required to understand if the child outcome is affected by the illness, medications, or a combination of both.
What's new this month in BMJ Journals
Authors: Harvey Marcovitch
Journal: BMJ (2005)

Apomorphine may relieve restless legsNine patients with severe restless legs syndrome were pretreated with domperidone for three days to mitigate side effects of apomorphine, which was given as an intravenous infusion.All patients responded with fewer movements and subjective improvement.These findings could be used as a test for the condition, the authors say, and transdermal or subcutaneous apomorphine might eventually prove therapeutic.
Erratum to: Open lung biopsy in nonresolving ARDS frequently identifies diffuse alveolar damage regardless of the severity stage and may have implications for patient management
Authors: Claude Guerin, Frédérique Bayle, Véronique Leray, Sophie Debord, Alina Stoian, Hodane Yonis, Jean-Baptiste Roudaut, Gael Bourdin, Mojgan Devouassoux-Shisheboran, Elodie Bucher, Louis Ayzac, Sylvie Lantuejoul, Carole Philipponnet, Jean Louis Kemeny, Bertrand Souweine, Jean-Christophe Richard
Journal: Intensive Care Medicine (2015)
Vertebral Sarcoidosis
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reptile-Associated Salmonellosis— Selected States, 1994-1995
Journal: JAMA (1995)

During 1998-2002, CDC received reports from state health departments regarding Salmonella infections in persons who had contact with reptiles (e.g., lizards, snakes, and turtles). Salmonella infections usually cause gastroenteritis but can result in invasive illness (e.g., septicemia and meningitis), especially in infants and immunocompromised persons. For decades, reptiles have been known as a source for salmonellosis; however, numerous reptile owners remain unaware that reptile contact places them and other household members, including children, at greater risk for salmonellosis. Increasing evidence suggests that amphibians (e.g., frogs, toads, newts, and salamanders) also can pose risks for salmonellosis in humans. This report describes cases of reptile-associated salmonellosis in six states, offers recommendations on preventing transmission of Salmonella from reptiles and amphibians to humans, and provides an update on state regulations mandating education at pet stores about salmonellosis.
HBV RNA decline without concomitant HBsAg decrease is associated with a low probability of sustained response and HBsAg loss
Authors: Sylvia Brakenhoff, Robert De Man, Andre Boonstra, Margo J.H. van Campenhout, Robert De Knegt, Florian van Bömmel, Annemiek Van der Eijk, Thomas Berg, Bettina Hansen, Harry Janssen, Milan Sonneveld
Journal: Journal of Hepatology (2020)
Medizinische Praxis: Sammlung für ärztliche Fortbildung.
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reproductive Toxicity of Commercial PCB Mixtures: LOAELs and NOAELs from Animal Studies
Authors: Mari S. Golub, James M. Donald, Joe A. Reyes
Journal: Environmental Health Perspectives (1991)

This paper reviews the developmental/reproductive toxicity ofcommercial polychlorinated biphenyl (PCB) mixtures in anhnals and reports on the "no-observable-adverse-effect levels" (NOAEI) and "lowest-observable-adverse-effect levels" (LOAELs) fromthese Identc nof the lwest effective doses for reproductive toxicity of PCB mixtures is diffiult becas avariety of roductive and _o effects have been reported in several species using different commercial mixtures.Factors to be considered include sensitiv of the end point, sensitivity of species, study quality, biological plausibility, and relevance to humans.End points affected at the lowest doses (sensitive end points) included postnatal groWth, dedopment, and functio Among species for whom seniiv end points have been evaluated, a LOAEL of0.25 mg/kg/day was identified for rodents on the basis ofdevelopmentl delas in growth and behavioral hfncon, and a LOEL of&MO mg/kday was identified for nonhuman at based on tal skin hyperpgmentation.NOELs were not identifiable for these sensitive end points because effects were reported at the lowest doses tested.Lower reproductive organ weights in offspring Impaired function in offspring Clophen AO Aroclor 1254 Aroclor 1248 Aroclor 1242 Aroclor 1254 Aroclor 1242 Aroclor 1248 Aroclor 1254 Aroclor
Commentaire du travail de Blick BL et al., pp. 626
Authors: Julien Branche, Maxime Palazzo, Marine Camus, Gabriel Rahmi, Gilles Lesur
Journal: Endoscopy (2015)

See also: The string sign for diagnosis of mucinous pancreatic cystsEndoscopy 2015; 47(07): 626-631DOI: 10.1055/s-0034-1391484
Comparing costs of radical cystectomy versus trimodal therapy for patients diagnosed with localized muscle-invasive bladder cancer.
Authors: Mohamed Danny Ray-Zack, Yong Shan, Preston Kerr, Christopher David Kosarek, Hogan K Hudgins, Usama Jazzar, Douglas S. Tyler, Stephen J. Freedland, Todd A. Swanson, Jacques G. Baillargeon, Jim C. Hu, Sapna Kaul, Ashish M. Kamat, John L. Gore, Hemalkumar B Mehta, Stephen Bentley Williams
Journal: Journal of Clinical Oncology (2019)

372 Background: Studies on the cost of muscle-invasive bladder cancer treatments lack granularity and are limited to 180 days. This study aimed to compare the one-year costs of trimodal therapy versus radical cystectomy, accounting for survival and intensity effects on total costs. Methods: Using Surveillance, Epidemiology, and End Results (SEER)-Medicare linked data, we included a total of 2,963 patients aged ≥66 years diagnosed with clinical stage T2-4a bladder cancer between 2002 and 2011. We compared total Medicare costs within one year of diagnosis among patients following radical cystectomy or trimodal therapy using inverse probability of treatment weighted (IPTW) propensity score models, which included a two-part estimator to account for intrinsic selection bias. Results: Median total costs were significantly higher for trimodal therapy than radical cystectomy in 90 days ($83,754 vs. $68,692; median difference $11,805, 95% CI $7,745 to $15,864), 180 days ($187,162 vs. $109,078; median difference $62,370, 95% CI $55,581 to $69,160), and 365 days ($289,142 vs. $148,757; median difference $109,027, 95% CI $98,692 to $119,363), respectively. Outpatient, radiology, pharmacy and pathology/laboratory costs contributed largely to the significantly higher costs associated with trimodal therapy. On IPTW-adjusted analyses, patients undergoing trimodal therapy had $142,337 (95% CI $117,423-$175,300) higher costs compared with radical cystectomy one year after treatment (Table). Conclusions: Compared to radical cystectomy, trimodal therapy was associated with higher costs among patients with muscle-invasive bladder cancer. Extrapolating cost figures to the total US population resulted in excess spending of $853 million for trimodal therapy compared with radical cystectomy for patients diagnosed in 2018. [Table: see text]
THE PRICE OF DIPHTHERIA ANTITOXIN.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Methicillin-Resistant Staphylococcal Infection: Control of Staff-Transmitted Infections
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sublingual Desensitization
Authors: Thomas M. Golbert
Journal: JAMA (1971)

<h3>To the Editor.—</h3> Samter's recommendation against sublingual desensitization was correct.<sup>1</sup>Subsequent letters<sup>2-3</sup>have indicated that this method is employed by some practitioners treating reagin (IgE, Type I) mediated allergic disease. Dickey<sup>3</sup>also advocated other precepts of Rinkel et al.<sup>4-5</sup>These practitioners represent a small portion of the allergy community. Most allergists practice in accordance with established immunological concepts, as summarized in several textbooks<sup>6-8</sup>and symposia.<sup>9-11</sup> Rinkel's precepts<sup>4-5</sup>include "optimal dosage" determined by intracutaneous or sublingual "titration," the intracutaneous "provocative test" with the so-called provoking and neutralizing doses, and sublingual desensitization. These methods are supported by uncontrolled, testimonial impressions only. The basis for asserting benefit is not indicated, and immunological data have not been offered. Recently the food provocative test has been subjected to a controlled investigation<sup>12</sup>and shown to be valueless. In contrast, the practice of allergy in accordance with immunologic principles
Molecular profiling predicts clinical outcome in patients with metastatic colorectal cancer treated with 5-FU/oxaliplatin
Authors: J. Yun, W. Zhang, D. Park, D. Yang, O. Press, M. Gordon, N. Mallik, H. J. Lenz
Journal: Journal of Clinical Oncology (2004)

3519 Background: Genetic polymorphisms have been shown to predict clinical outcome to 5-Fluorouracil/Oxaliplatin chemotherapy in patients with colorectal cancer. We have shown in retrospective studies on patients with metastatic colorectal cancer that polymorphisms in the DNA repair pathway genes XPD751, ERCC1, metabolizing gene GSTP1, and target gene TS5', TS3'UTR are predictive to clinical outcome to 5-FU/Oxaliplatin. In a prospective study, we analyzed these polymorphisms along with XPD312, XPD156, and TS5'SNP to confirm identified patterns. We also analyzed the polymorphism in the COX-2 gene, which is associated with angiogenesis in colorectal cancer. Methods: 168 patients with stage IV metastatic colorectal cancer were enrolled and received 5-FU/Oxaliplatin after failing CTP-11. 130 patients (68 ♂,62 ♀) with median age 60 years (25 to 87) had sufficient follow up time for analysis. Median follow up time was 16.6 months. Genomic DNA was extracted and analyzed by a PCR-based RFLP technique. Results: A univariate analysis of the genotypes showed XPD156 was significant for response to chemotherapy (p=.04). Patients with the A/A genotype in XPD156 had greater response compared to patients with the C/C genotype. GSTP1 (p=.08), TS5' (p=.10), and TS3'UTR (p=.07) showed a trend for response. From the table below, GSTP1 and TS5'SNP were significant for survival and XPD312 showed a trend. Conclusion: The data confirms that genes identified retrospectively GSTP1, TS, and XDP may predict survival and response in patients with colorectal cancer who received 5-FU/Oxaliplatin. The data on the polymorphisms are in contrast to our retrospective study, indicating that further functional analysis is critical to understanding their role in chemosensitivity. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Chiron
BERLIN LETTER.
Authors: None H. R. B.
Journal: JAMA (1885)

Berlin,Jan. 20, 1885. The following interesting case came to Prof. Fränkel's clinic : The man, some years ago, was affected with paralysis of the external rectus of the left side, which gradually disappeared under the use of iodide of potassium and mercury. At present the patient has great difficulty in swallowing, and examination shows paralysis of the palato-glossus, palato-phatyngeus, tensor palati, crico-arytaenoideus, post lower pharyngeal muscle, and paresis of the oesophagus on the left side. Ten days' treatment with iodide of potassium has produced a marked improvement. The character of the paralysis points to an affection within the cranium of the glosso-pharyngeal and pneumo-gastric nerves, and possibly of the accessorius on the left side. Placenta praevia was discussed by Dr. Winter at the last meeting of the Obstetrical and Gynaecological Society. At the same time Dr. Schroeder demonstrated a frozen, complete longitudinal section of a woman at full term
British Medical Journal
Journal: BMJ (1865)

the patient was miiuchl1 imiproved in health.The local condition talso steadlily imiprovedl, catre being taken to provi(de a free egrress for pus, att oIi or otller sile cf the wrist, as occasion arose.-r,w general treatment, I need only say, was of the iiiost supporting cha- racter.