tbuckley/cabot-search huggingface dataset:
A Manual on Foot Care and Shoe Fitting for Officers of the U. S. Navy and U. S. Marine Corps.
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Calvin Settlage, MD: looking at children
Authors: E. R. Gonzalez
Journal: JAMA (1981)

A new mother is distraught because her 2-year-old refuses to drink his milk or go to bed. He is stubborn, defiant, impossible! During a consultation with Calvin F. Settlage, MD, the mother gains insight. Settlage gently explains that the issue is not willful misbehavior but<i>autonomy</i>. "If the mother understands that this is a developmental issue the child is struggling with—that he needs to have the leeway to be in charge of himself—that changes the whole ballgame for her," he says. Settlage is a child psychiatrist and psychoanalyst who is director of education and chairman of the education committee at the San Francisco Psychoanalytic Institute. He is also one of a growing band of psychoanalysts who view the primary dyadic, or two-person (usually mother-child or father-child) relationship in the first few years of life as a crucial determinant of future mental health or illness. Their studies of young children are
Hereditary Hemochromatosis
Authors: Om Parkash, Muhammad Akram
Journal: New England Journal of Medicine (2004)

The case of a 43-year-old male is presented, with diagnosed diabetes mellitus,heart failure, skin pigmentation, hepatic cirhosis, and hereditary hemochromatosis confirmed by liver biopsy. The objective of this publication is to have hemochromatosis in mind as a differential diagnosis in a middle-aged patient with several pathologies and organs involved.
Disaster Medicine
Authors: Simone Vanni
Journal: Annals of Internal Medicine (2007)

Medical Writings: Book Notes15 May 2007Disaster MedicineSimone Vanni, MD, PhDSimone Vanni, MD, PhDFrom Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-146-10-200705150-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Ciottone GR, ed. 984 pages. St. Louis: Mosby; 2006. $99.00. ISBN 0323032532. Order at www.us.elsevierhealth.com.Field of medicine: Emergency medicine.Format: Hardcover book.Audience: Medical professionals who care for victims and survivors of disasters.Purpose: To develop a comprehensive understanding of disaster medicine and its role in disaster management.Content: Disaster medicine is perhaps the most interdisciplinary of all fields of medicine, and few physicians are familiar with its principles, unique organizational demands, and clinical aspects. This book offers an exhaustive guide to the preparation, response, recovery, and mitigation or prevention of a full range of disasters, both natural and ... Author, Article, and Disclosure InformationAffiliations: From Azienda Ospedaliero-Universitaria Careggi, Florence, Italy. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPerioperative glycemic control with a computerized algorithm versus conventional glycemic control 15 May 2007Volume 146, Issue 10Page: 760KeywordsAcademic medicineBiologicsComputersEmergency medicineNatural disastersSoftware tools ePublished: 15 May 2007 Issue Published: 15 May 2007 Copyright & PermissionsCopyright © 2007 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Randomised controlled trial of non-directive counselling, cognitive-behaviour therapy, and usual general practitioner care for patients with depression. I: Clinical effectiveness
Authors: E. Ward, M. King, M. Lloyd, P. Bower, B. Sibbald, S. Farrelly, M. Gabbay, N. Tarrier, J. Addington-Hall
Journal: BMJ (2000)

<h3>Abstract</h3> <b>Objective:</b> To compare the clinical effectiveness of general practitioner care and two general practice based psychological therapies for depressed patients. <b>Design:</b> Prospective, controlled trial with randomised and patient preference allocation arms. <b>Setting:</b> General practices in London and greater Manchester. <b>Participants:</b> 464 of 627 patients presenting with depression or mixed anxiety and depression were suitable for inclusion. <b>Interventions:</b> Usual general practitioner care or up to 12 sessions of non-directive counselling or cognitive-behaviour therapy provided by therapists. <b>Main outcome measures:</b> Beck depression inventory scores, other psychiatric symptoms, social functioning, and satisfaction with treatment measured at baseline and at 4 and 12 months. <b>Results:</b> 197 patients were randomly assigned to treatment, 137 chose their treatment, and 130 were randomised only between the two psychological therapies. All groups improved significantly over time. At four months, patients randomised to non-directive counselling or cognitive-behaviour therapy improved more in terms of the Beck depression inventory (mean (SD) scores 12.9 (9.3) and 14.3 (10.8) respectively) than those randomised to usual general practitioner care (18.3 (12.4)). However, there was no significant difference between the two therapies. There were no significant differences between the three treatment groups at 12 months (Beck depression scores 11.8 (9.6), 11.4 (10.8), and 12.1 (10.3) for non-directive counselling, cognitive-behaviour therapy, and general practitioner care). <b>Conclusions:</b> Psychological therapy was a more effective treatment for depression than usual general practitioner care in the short term, but after one year there was no difference in outcome.
Environmental Pollution and Child Health in Central and Eastern Europe
Authors: Edward F. Fitzgerald, Lawrence M. Schell, Elizabeth G. Marshall, David O. Carpenter, William A. Suk, Jan E. Zejda
Journal: Environmental Health Perspectives (1998)

For the last 50 years, the economic and industrial development of the nations of Central and Eastern Europe has been achieved at the cost of environmental degradation. The health risks posed by this pollution to children and the steps necessary to ameliorate such risks are only beginning to be investigated. At a recent conference in Poland, sponsored in part by the National Institute of Environmental Health Sciences, participants from 11 countries in the region, together with scientists from Western Europe and the United States, met to share information regarding pediatric environmental health in Central and Eastern Europe, to consider methodologic issues in the design and conduct of such studies, and to discuss preventive strategies. This report summarizes the deliberations, outlines problem areas such as heavy metals and air pollution, delineates research and training needs to help Central and Eastern Europeans deal more effectively with such problems, and recommends specific future actions and collaborative efforts.
Pleural Biopsy
Authors: Louis J. Kettel
Journal: JAMA (1967)

A disease process in the periphery of the lung commonly involves the parietal pleura and frequently is associated with an effusion. Careful study of the chemical, bacteriologic, and cellular composition of pleural fluid may be highly informative and occasionally diagnostic, but the results of these studies also may be nonspecific despite definite diagnostic histological changes in the pleura. The value of microscopic examination of a portion of pleura was established initially from specimens obtained by open surgical biopsy through a limited thoracotomy.<sup>1</sup>This initiated interest in needle biopsy which has now largely replaced the more complex open surgical procedure. Tuberculosis, other granulomatous diseases, and tumors, either primary or metastatic to the pleura, are the most common specific diagnoses obtained from pleural biopsy specimens. The biopsy needle removes a small fragment of parietal pleura suitable for histological examination. Three general types of needles have been used: (1) Vim-Silvermann, an end-biting
Clinique médicale des enfants: Maladies infectieuses. Deuxième série: Rougeole, scarlatine, coqueluche, pneumococcies, streptococcies, purpura infectieux, méningites à méningocoques, à bacilles de Pfeiffer, maladie de Heine-Médin. paludisme.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diarrhoea of famine and malnutrition: investigations using a rat model. 1. Jejunal hypersecretion induced by starvation.
Authors: A Young, R J Levin
Journal: Gut (1990)

The effects of progressive starvation for up to three days on the secretory functions of the intestine were investigated using in vitro and in vivo preparations of rat jejunum and secretagogues whose action was either through cyclic AMP or Ca++. Initial starvation for 24 h (day 1) did not significantly alter the basal net electrogenic ion secretion measured in vitro as the short circuit current (Isc, muamps/cm2) or the change in electrogenic ion secretion (delta Isc) induced by the secretagogues. By day 2 of starvation, however, the maximum delta Isc transient induced by the cholinergic and other secretagogues (delta Isc = Isc max-basal Isc) was greatly increased (up to a maximum of 117%) compared with the fed controls on an area basis. The delta Isc were even greater on day 3 of starvation. If a tissue weight basis was used to normalise the data the increase became even more marked. The enhancement in secretion was not caused by a decrease in absorptive capacity as glucose, added mucosally, gave larger increases in absorptive currents in the starved than in the fed jejuna. Bethanecol dose-delta Isc response curves in fed and starved jejuna showed an increase in the maximum electrogenic secretion in the starved but no apparent change in the affinity of their cholinergic receptors mediating the enhanced secretion. The starvation-induced increase in secretion elicited by bethanecol was blocked by atropine, indicating that the receptors were muscarinic, but was unaffected by tetrodotoxin indicating that the enteric neural innervation was not essential for its expression. Noradrenaline released by tyramine was greater in the starved than the fed jejunum, suggesting that a decreased sympathetic tone was unlikely to be the major cause of the starvation induced secretory enhancement. Measurement of jejunal fluid movements in vivo showed that in fed controls and throughout the three days of starvation there was an unchanged net fluid absorption in the basal, unstimulated state. By day 2 and day 3 of starvation, however, bethanecol stimulated fluid secretion was very much greater than that of the fed controls. This increase in fluid secretion was concomitant with significant increases in the concentration of chloride in the lumenal fluid. Starvation thus appears to make the rat jejunum hypersensitive to cholinergic and other secretagogues, increasing the electrogenic secretion of chloride in vitro and that of chloride and fluid in vivo. These results obtained with the rat model give a new insight into possible mechanisms by which the diarrhoea of human famine and malnutrition may be expressed.
Society Proceedings
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Computer-Assisted Studies of Molecular Structure and Genotoxic Activity by Pattern Recognition Techniques
Authors: Terry R. Stouch, Peter C. Jurs
Journal: Environmental Health Perspectives (1985)

Often a compound's biological activity is determined by complex relationships between its structural components. Such a relationship often can only be adequately described and exploited by multivariate structure-activity relationship (SAR) studies that can deal with many variables simultaneously. Pattern recognition (PR) is a multivariate technique that is well suited for the qualitative, active-inactive, data that is often supplied by biological assays. PR studies of compounds of known activity can yield information that will allow the prediction of the activity of untested compounds. ADAPT is a computerized system that was developed for such PR-SAR studies. A general introduction to this field is presented and the methodology used for such a study is described in the context of an actual study of mutagenic compounds. The data requirements, descriptor generation, and the details of a PR study are discussed. In addition, the example study was chosen to highlight the problems that may occur if a study is not well formulated and carefully executed. Current work and future plans for computerized mutagen screening are discussed.
CSL–MAML-dependent Notch1 signaling controls T lineage–specific IL-7Rα gene expression in early human thymopoiesis and leukemia
Authors: Sara González-García, Marina García-Peydró, Enrique Martín-Gayo, Esteban Ballestar, Manel Esteller, Rafael Bornstein, José Luis de la Pompa, Adolfo A. Ferrando, María L. Toribio
Journal: The Journal of Experimental Medicine (2009)
Phase II study of bevacizumab (BEV), temozolomide (TMZ), and hypofractionated stereotactic radiotherapy (HFSRT) for newly diagnosed glioblastoma (GBM).
Authors: A. M. P. Omuro, K. Beal, S. Karimi, D. Correa, T. A. Chan, L. M. DeAngelis, I. T. Gavrilovic, C. Nolan, A. Hormigo, A. B. Lassman, T. J. Kaley, I. K. Mellinghoff, C. Grommes, K. Panageas, A. S. Reiner, R. Barradas, L. E. Abrey, P. H. Gutin
Journal: Journal of Clinical Oncology (2011)

2028 Background: Pre-clinical data suggest BEV may sensitize tumor endothelia to RT and disrupt vascular niches harboring cancer stem cells. Due to radioprotective effects, BEV also allows for more aggressive RT schedules such as HFSRT. We initiated a phase II trial in newly diagnosed GBM utilizing HFSRT, BEV and TMZ. Methods: Pts with tumor volume under 60cc were eligible. HFSRT was given in 6 treatments over 2 weeks: 6x6 Gy to contrast-enhancing tumor and 6x4 Gy to FLAIR hypersignal, with dose painting, concomitant with BEV (10 mg/kg every 2 weeks) and TMZ (75mg/m2 daily), followed by adjuvant BEV/ TMZ (150-200 mg/m2 in 5/28 days). Followup included perfusion MRI (PWI) and comprehensive neuropsychological assessment (NPA) in all patients. Primary endpoint was 1y overall survival (OS): single-stage binomial design; promising: 70%, non-promising: 50%; α and β=0.1). Results: Accrual was completed (N=40 evaluable pts; 14 women; median age: 55y; median KPS: 90). The frequency of methylated MGMT promoter was low (methylated: 8 pts, unmethylated: 26, not done: 6). Grades 3/4 non-hematologic toxicities included pulmonary embolism (2), thrombotic microangiopathy/renal failure (1), wound infection (1), colitis (1). The median PFS was 11m (95% CI 9-15). No pt had pseudo progression. Among 30 evaluable pts, response (Macdonald criteria) was complete in 27%, partial in 63%; disease was stable in 3% and 7% progressed. Fifteen pts have died; the 1-y OS is 90% (CI 73-97); median followup: 13m. NPA at baseline showed decreased verbal memory, but no statistically significant changes at 4 and 8m followup. PWI showed early decreases in relative cerebral blood volume (rCBV): mean rCBV at baseline=2.77 versus 1.65 at 6 weeks (p=0.01); rCBV anticipated achieved responses. Conclusions: Despite a more aggressive RT schedule, the regimen was safe and more convenient for pts (shorter treatment, high response rates, preserved cognitive function throughout and following RT). Compared to historical controls, prolonged PFS and 1y OS were observed. While evaluation of late survival endpoints requires longer followup, the primary endpoint was met, indicating a randomized study is warranted.
What's hot that the other lot got
Authors: Ben Soar
Journal: Thorax (2017)

Many patients with venous thromboembolism (VTE) require extended treatment beyond the standard 6 months if they are felt to be at high risk of recurrence.It remains uncertain as to whether full or lower intensity anticoagulation is required.This randomised, double-blind, phase III trial (Weitz et al.N Engl J Med 2017;376:1211-22) compared once daily rivaroxaban at 20 mg or 10 mg doses with 100 mg of aspirin.Each patient had already completed 6-12 months of treatment dose anticoagulation therapy.A total of 3365 patients were included.The primary efficacy outcome was symptomatic recurrent VTE, and the principal safety outcome was major bleeding.The rate of symptomatic VTE was 1.5% in the 20 mg rivaroxaban group, 1.2% in the 10 mg rivaroxaban group and 4.4% in those receiving aspirin ( p<0.001 for both rivaroxaban doses vs aspirin).Rates of major bleeding were 0.5% in the 20 mg rivaroxaban group and 0.4% in the 10 mg rivaroxban group and 0.3% in the aspirin group.Non-major bleeding rates were 2.7%, 2% and 1.8%, respectively.The authors conclude that the risk of recurrent VTE was significantly lower in the 20 mg and 10 mg rivaroxaban groups than the aspirin group without a significant increase in bleeding rates.
Abstract B51: Extracellular matrix control of metastasis and dormancy
Authors: Lauren E. Barney, Ari Gilman, Arthur Mercurio, Shelly R. Peyton
Journal: Cancer Research (2016)

Abstract This abstract is being presented as a short talk in the scientific program. A full abstract is printed in the Proffered Abstracts section (PR14) of the Conference Proceedings. Citation Format: Lauren E. Barney, Ari Gilman, Arthur Mercurio, Shelly R. Peyton. Extracellular matrix control of metastasis and dormancy. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Metastasis; 2015 Nov 30-Dec 3; Austin, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(7 Suppl):Abstract nr B51.
Ronna Siegel, MD, is 17th Fishbein Fellow
Authors: P. Gunby
Journal: JAMA (1997)

TO INSURE that the voices of public health advocates will be heard if Congress enacts legislation to settle the rising tide of lawsuits against the tobacco industry, former US Surgeon General C. Everett Koop, MD, has convened an Advisory Committee on Tobacco Policy and Public Health. In addition to co-chairs Koop and former US Food and Drug Administration commissioner David Kessler, MD, JD, the panel includes: John Banzhaf, Action on Smoking and Health; Mike Pertschuk, Advocacy Institute; Robert Graham, MD, American Academy of Family Physicians; George Comerci, MD, American Academy of Pediatrics; John Seffrin, American Cancer Society; D. Robert McCaffree, MD, American College of Chest Physicians; George Anderson, MD, American College of Preventive Medicine; Dudley Hafner, American Heart Association; John Garrison, American Lung Association; Randolph Smoak, MD, American Medical Association; Thomas Houston, MD, Smokeless States National Program; Barbara Levine, American Public Health Association; Anne Marie O'Keefe, Americans for Non-Smokers Rights;
Received
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal