tbuckley/cabot-search huggingface dataset:
Murky Water
Authors: Cathryn J. Lapedis
Journal: Annals of Internal Medicine (2018)

On Being a Doctor18 September 2018Murky WaterCathryn J. Lapedis, MD, MPHCathryn J. Lapedis, MD, MPHMichigan Medicine, Ann Arbor, Michigan (C.J.L.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M18-1398 Audio Reading - “Murky Water” Audio. Virginia L. Hood, Annals Associate Editor, reads "Murky Water," by C.J. Lapedis. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail I jumped as my pager beeped loudly, announcing that the United States Medical Licensing Examination Step 1 scores had been posted. My heart was pounding and my hands were sweating as I frantically searched the hospital for a private computer to check my score. Scenes of lectures from the first 2 years of medical school flashed in my mind, reminding me that the score of this one test would determine my future life as a physician. Leaders of our school spoke of the test the way rabbis spoke of the decree in the Book of Life on Yom Kippur. They ... Author, Article, and Disclosure InformationAffiliations: Michigan Medicine, Ann Arbor, Michigan (C.J.L.)Acknowledgment: The author thanks Sarah's family for their generous support in publishing this essay. The name of the student was changed to protect their privacy.Corresponding Author: Cathryn J. Lapedis, MD, MPH, 2800 Plymouth Road, Building 14 G100-29, Ann Arbor, MI 48109-2800; e-mail, [email protected]umich.edu. PreviousarticleNextarticle Advertisement Audio Reading - “Murky Water” Audio. Virginia L. Hood, Annals Associate Editor, reads "Murky Water," by C.J. Lapedis. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetailsSee AlsoBurnout Contagion Cathryn J. Lapedis and Lisa M. Meeks Burnout Contagion Lawrence K. Loo and Daniel I. Kim Metrics Cited byReligious Service Attendance and Deaths Related to Drugs, Alcohol, and Suicide Among US Health Care ProfessionalsBurnout ContagionLawrence K. Loo, MD and Daniel I. Kim, MDPhysicians’ Goodness and Guilt—Emotional Challenges of Practicing MedicineMental Health and Medical Education 18 September 2018Volume 169, Issue 6Page: 415-416KeywordsAnxietyEmotionsFearForecastingHeartMemoryPainPsychiatry and mental healthSleepSuicide ePublished: 18 September 2018 Issue Published: 18 September 2018 Copyright & PermissionsCopyright © 2018 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Hyporeninemic Hypertension
Authors: S Vaisrub
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Diagnosis and Treatment of Diseases of the Rectum. Being a Practical Treatise on Fistula, Piles, Fissure and Painful Ulcer, Procidentia, Polypus, Stricture, Cancer, etc.
Journal: JAMA (1902)

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Abstract 1042: Cellular plasticity and migratory modalities in high-grade serous ovarian carcinoma
Authors: Sharmila A. Bapat, Sagar Varankar
Journal: Cancer Research (2019)

Abstract Epithelial-mesenchymal (E-M) switch associated plasticity is crucial for the gradual destabilization of tumor tissue architecture to facilitate metastasis. Several studies towards comprehension of the metastatic cascade employ an overview of the phenotype specific markers and their association with distinct functionalities of migration, invasion, stemness, anoikis resistance, ECM remodeling, etc. Recent work on the dissection of phenotypic transitions has identified the existence of transitionary intermediate states across multiple cancers which exhibit greater plasticity as compared to the two phenotypic extremes. In a previous study from our group, we successfully identified molecular subclasses in high grade serous ovarian carcinoma (HGSC) that were associated with distinct modes of metastatic dissemination viz., collective cell migration (CCM) and EMT. Towards, elucidating contributions of distinct phenotypic states to CCM and EMT along with a comprehension of associated molecular regulators we resolved a phenotypic spectrum along the E-M axis. Identification of five phenotypic states followed by their functional characterization was associated with differential migratory capabilities that were further dissected with the aid of live cell imaging to quantitatively distinguish CCM and EMT. Enhanced visual output and extraction of three quantitative metrics viz., displacement, velocity and nearest neighbours generated an informative tool for assessing migratory modes in vitro. Furthermore, these metrics identified migratory modalities inclusive of wound closure by proliferation (passive CCM), sheet-like cell migration (active CCM) and individual cell migration (EMT). Interestingly, phenotypic status and migratory modes across the spectrum emerged as a consequence of a balance between expression and differential sub-cellular localization of two transcription factors viz. Tcf21 and Slug. Application of the novel migratory analyses in view of chemotherapeutic challenges identified the emergence of an epithelial state across the spectrum facilitated by Tcf21 mediated Slug repression and resulted in a switch from EMT to aCCM-mediated migration. Our study thus provides a comprehensive dissection of the E-M axis in HGSC in view of associated functional attributes. Acknowledgements: DBT Indo-Finnish Collaborative Grants, DBT Indo-Australia Collaborative Grants and NCCS Intramural Grants to SAB funded this research. SSV received fellowship from CSIR. Citation Format: Sharmila A. Bapat, Sagar Varankar. Cellular plasticity and migratory modalities in high-grade serous ovarian carcinoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1042.
Handbuch der inneren Sekretion: Eine iimfassende Darstellung der Anatomie, Physiologie, und Pathologie der endokrinen Drüsen.
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ciguatera fish poisoning
Authors: J. G. Morris
Journal: JAMA (1980)

Ciguatera fish poisoning, with its characteristic gastrointestinal and neurological symptoms, has been clearly described in literature from the West Indies since the 18th century, with fragmentary reports dating back to the 1500s.<sup>1</sup>It is currently a major cause of morbidity in the Caribbean,<sup>2</sup>as well as in the South Pacific, where Bagnis and his colleagues<sup>3</sup>have recently reported on a series of more than 3,000 cases. In the United States 94 outbreaks (418 cases) have been reported to the Center for Disease Control (CDC) through the national foodborne disease surveillance system since 1970, making ciguatera the most frequently reported foodborne disease associated with consumption of seafood; outbreaks have occurred most frequently in southeastern Florida and Hawaii, with sporadic cases, usually associated with a history of travel to the Caribbean, reported from other parts of the country. The CDC data undoubtedly represent substantial underreporting of the disease, however.
THE SECOND CHILDHOOD YEAR
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Four models of the physician-patient relationship
Authors: E. J. Emanuel
Journal: JAMA (1992)

DURING the last two decades or so, there has been a struggle over the patient's role in medical decision making that is often characterized as a conflict between autonomy and health, between the values of the patient and the values of the physician. Seeking to curtail physician dominance, many have advocated an ideal of greater patient control.<sup>1,2</sup>Others question this ideal because it fails to acknowledge the potentially imbalanced nature of this interaction when one party is sick and searching for security, and when judgments entail the interpretation of technical information.<sup>3,4</sup>Still others are trying to delineate a more mutual relationship.<sup>5,6</sup>This struggle shapes the expectations of physicians and patients as well as the ethical and legal standards for the physician's duties, informed consent, and medical malpractice. This struggle forces us to ask, What should be the ideal physician-patient relationship? We shall outline four models of the
ALASKA AS A HEALTH RESORT.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
From the Assistant Secretary for Health, US Public Health Service
Authors: J. O. Mason
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diseases of the Chest, Chicago
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
DR. GEORGE H. SIMMONS
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Government Services
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Authors Reply
Authors: Morgane Solis, Aurélie Velay, Bruno Moulin, Sophie Caillard, Samira Fafi-Kremer
Journal: Journal of the American Society of Nephrology (2018)

We thank Nickeleit et al.1 for their comment. In their response, they showed that newborn mice with murine polyomavirus (MPyV) IgG antibodies were protected against autologous MPyV infection and did not develop nephropathy, whereas naive animals exhibited very high plasma MPyV loads in plasma and tissue as well as morphologic signs of nephropathy.1 These results clearly show the role of the humoral response in protecting mice against severe polyomavirus infection. In humans, the role of antibodies in controlling BK virus (BKV) infection has been obscured by the fact that traditional tests that have been used for previous serology studies do not differentiate between different BKV genotypes.2 Recently, Buck and colleagues3 developed a method using reporter pseudoviruses on the basis of individual representatives of the different BKV genotypes that provides an accurate measure of the BKV-specific antibody response. They showed that BKV genotypes represent distinct serotypes with respect to neutralizing antibody responses.4 Using this test, we were able to shed new light on the role of the humoral response against BKV infection and nephropathy in kidney transplantation.5 Similar results have recently been reported for another polyomavirus, the JC virus, that causes opportunistic brain disease progressive multifocal leukoencephalopathy (PML).6 The authors showed that deficient humoral immunity is a common aspect of the pathogenesis of PML and that vaccination could stimulate and expand humoral immunity against JC virus, thus protecting individuals at risk from developing PML.6 Overall, these data provide strong evidence that strengthening the polyomavirus-specific humoral response by passive immunization or vaccination would be an effective antiviral preventive and/or therapeutic strategy. Disclosures None.
Is there an epidemic of chronic candidiasis in our midst?
Authors: E. R. Blonz
Journal: JAMA (1986)

THERE IS a growing underground of public controversy surrounding the reputed presence of a "new epidemic." This epidemic involves chronic candidiasis, a condition in which there is an overgrowth of and systemic invasion by the yeast organism<i>Candida albicans</i>. The<i>Candida</i>organism is ubiquitous in our environment, is a normal inhabitant of the large intestine, and is typically the identifiable organism in vaginal yeast infections (vulvovaginal candidiasis). Of late, a growing popular connotation of "candidiasis" is no longer limited to the female malady. It has come to signify a chronic condition with a new panoply of symptoms. Perhaps the original proponent of this popular<i>Candida</i>theory is C. O. Truss, MD, of Birmingham, Ala.<sup>1</sup>His hypothesis states that a number of conditions, such as an overuse of antibiotics, will decrease<i>Candida's</i>naturally occurring competitors in the large intestine. This creates an imbalance and facilitates an overgrowth of the<i>Candida</i>
JUVENILE SCROFULA AND PHTHISIS.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PLN-74809, a clinical-stage, dual alphaVbeta6/alphaVbeta1 integrin inhibitor, reduces fibrosis in a preclinical model of biliary fibrosis and precision-cut liver slices from primary sclerosing cholangitis and primary biliary cholangitis patients
Authors: Johanna Schaub, Chun Chen, Martin Decaris, Steve Ho, Gail Lee, Vikram Rao, Megan Marlow, Shamra Martin, Tony Chen, Jianfeng Wu, Christina Dooka, Jake Cha, Manuel Munoz, Katerina Leftheris, Eduard Gorina, Eric Lefebvre, Scott Turner
Journal: Journal of Hepatology (2020)