tbuckley/cabot-search huggingface dataset:
Coronary artery wounds treated with saphenous vein bypass grafts
Authors: A. J. Tector
Journal: JAMA (1973)

Two patients with penetrating wounds to the left anterior descending coronary artery were treated with emergency aortocoronary saphenous vein bypass grafts. On follow-up angiography, the first patient's bypass graft to the distal anterior descending coronary artery was not patent. The second patient's graft to the proximal anterior descending vessel was patent with bidirectional flow. Both patients had other associated intracardiac injuries, the first having an aortic-right ventricular fistula requiring reoperation. It is desirable, and often necessary, to reestablish coronary artery continuity of flow following injury. We propose a protocol to detect other associated intracardiac defects prior to emergency cardiopulmonary bypass so that these lesions might be repaired, obviating excess postoperative morbidity, mortality, and subsequent reoperation.
A Protest.
Authors: P. Maxwell Foshay
Journal: JAMA (1899)

Cleveland, Ohio, June 16, 1899. <h3>To the Editor:</h3> —I am informed by a correspondent in Iowa that my name is being used in a circular concerning a quack cancer cure called "Vitalia." Any such use of my name is absolutely unauthorized and an outrage on common business honesty. I presume legal redress is impossible or the indecency would not have been committed. Would it be asking too much of you to publish my protest? Not perhaps that many may be misled by my name, but to put others on their guard who are no doubt being similarly victimized. The animus of the thing is probably an attempt at revenge for an editorial criticism which I wrote in the<i>Cleveland Journal of Medicine</i>a year or more ago, warning the profession of the methods of the concern which exploits this "cure." Very respectfully,
Correction to: A novel protein encoded by a circular RNA circPPP1R12A promotes tumor pathogenesis and metastasis of colon cancer via Hippo-YAP signaling
Authors: Xiao Zheng, Lujun Chen, You Zhou, Qi Wang, Zhuojun Zheng, Bin Xu, Chen Wu, Qi Zhou, Wenwei Hu, Changping Wu, Jingting Jiang
Journal: Molecular Cancer (2021)

An amendment to this paper has been published and can be accessed via the original article.
In Response
Authors: Margaret E. Wright, Demetrius Albanes
Journal: Cancer Research (2009)

In Response:We thank Drs. Zingg and Azzi for their comments regarding our article (1), and for bringing to our attention their recent report characterizing the α-tocopherol transport activity and expression pattern of three tocopherol associated proteins (hTAPs; ref. 2). Although we did not observe an association between variants in two vitamin E transport genes, TTPA and SEC14L2, and prostate cancer risk, we did show that several polymorphisms in SEC14L2 modified the relation between vitamin E supplementation, α-tocopherol intake, and prostate cancer risk. Most of these modifying variants, however, did not exhibit significant genotype-serum phenotype associations.As pointed out, circulating and tissue concentrations of α-tocopherol are influenced by many genes, including those involved in uptake, plasma transport, cellular uptake and efflux, and metabolism of lipids and cholesterol, and we acknowledged in our discussion that a more comprehensive evaluation of additional genes would be useful. The genes we selected, however, are currently two of the most promising candidates with respect to vitamin E activity in the prostate with the α-tocopherol transport protein (α-TTP) being responsible for concentrating this specific isomer in the blood (3), and the α-tocopherol-associated protein (hTAP1) binding α-tocopherol with greater affinity than other isoforms and being highly expressed in prostate tissue (4). Nevertheless, a more comprehensive approach in which variation across all genes that potentially influence vitamin E activity (including SEC14L3 and SEC14L4) is considered should yield further insights, particularly into the interplay with cholesterol and steroid hormone biosynthesis.Although we agree that vitamin E levels and activity in prostate tissue may be more relevant to cancer risk than circulating concentrations alone, it is important to note that plasma and prostatic tocopherol levels are significantly correlated (5), indicating that the former are a relatively good proxy for concentrations in this target organ. This is fortunate, given that prostate tissue is difficult to obtain in epidemiologic studies and examination of blood-based biomarkers is therefore essential.We strongly believe that future efforts should focus on fully characterizing the extent of variation across TTPA, SEC14L2, and other genes that may impact vitamin E status and function, and that as Zingg and Azzi observe, basic research into the functionality of these genes and their variants is critically needed. These pursuits could have important implications regarding the design, analysis, and interpretation of chemoprevention trials, including SELECT (6).No potential conflicts of interest were disclosed.
Problems of comorbidity in mortality after prostatectomy
Authors: J. Concato
Journal: JAMA (1992)

<h3>Objective.</h3> —In recent studies of patients with benign prostatic hyperplasia (BPH), men undergoing transurethral resection of the prostate (TURP) had higher long-term mortality than men undergoing open prostatectomy. We tested the hypothesis that the higher mortality for patients undergoing TURP could have occurred if these patients were older and sicker at the time of surgery than patients undergoing open prostatectomy. <h3>Design and Setting.</h3> —Retrospective cohort study at Yale—New Haven (Conn) Hospital. <h3>Patients.</h3> —Two hundred fifty-two men who underwent TURP or open prostatectomy from 1979 through 1981 for the treatment of BPH. <h3>Main Outcome Measures.</h3> —Five-year mortality adjusted for age and severity of comorbid illness at the time of surgery. <h3>Results.</h3> —The crude 5-year mortality rates were 17.5% (22 of 126 patients) for the TURP group and 13.5% (17 of 126 patients) for the open group. At the time of surgery, however, patients in the TURP group were sicker and older than patients in the open group. As the detail and quality of the assessment of comorbidity increased, the adjusted risk of TURP decreased. Improved classifications of comorbidity in three different forms of statistical analysis did not show an effect of type of prostatectomy on long-term mortality (Mantel-Haenszel relative risk, 1.03; 95% confidence interval, 0.57 to 1.87). <h3>Conclusions.</h3> —These results suggest that TURP does not increase long-term mortality after surgery for the treatment of BPH. Inadequate accounting for severity of illness may also affect other statistical "adjustments" used in research concerned with patient outcomes. (<i>JAMA</i>. 1992;267:1077-1082)
Activation analysis.
Journal: BMJ (1968)

Detailed information on the chemical composition of the body remains for the most part tantalizingly out of reach.Direct chemical analysis of normal adult cadavers is restrained by formidable difficulties and has seldom been achieved.Indirect methods, including balance studies and dilution tech- niques (with radioactive or stable tracers), give information, but we still have no reliable way of estimating, for example, the total amount of sodium or calcium in the body.The method of activation analysis has many applications in biology and medicine.' 2 In a novel use recently reported by G. W. K. Donaldson and colleagues at page 585 of the
Studies in Neurology.
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Evaluation and management of the patient with syncope
Authors: W. N. Kapoor
Journal: JAMA (1992)

<h3>Objective.</h3> —To review the studies on diagnostic evaluation of syncope and to provide an approach to the diagnostic testing and management of this condition. <h3>Data Source.</h3> —Published studies on the evaluation of syncope in the English language. <h3>Study Selection.</h3> —Cohort studies and case series of patients presenting with syncope and focused studies of various diagnostic tests such as prolonged electrocardiographic monitoring, electrophysiologic studies, and upright tilt testing. Specific selection criteria were used in the case of prolonged electrocardiographic monitoring, in which all studies had to have performed at least 12 hours of monitoring. <h3>Data Extraction.</h3> —Studies reviewed by the author. <h3>Data Synthesis.</h3> —Studies in the 1980s have shown that a cause of syncope is not diagnosed in as many as 47% of the patients presenting with this symptom. When a cause of syncope is established, a history and physical examination lead to the identification of 56% to 85% of the causes. In the remaining patients, arrhythmia detection is a central issue. A major problem with the use of ambulatory electrocardiographic (Holter) monitoring in the diagnosis of arrhythmias is that symptomatic correlation with arrhythmias is rarely found (only 4% of patients). Increasing the duration of monitoring from 24 to 72 hours does not lead to increased yield of symptomatic arrhythmias. Patient-activated intermittent loop recorders that can be worn for several weeks may occasionally show a symptomatic correlation, but they are most useful in patients with multiple recurrences of syncope. Electrophysiologic studies are more likely to be abnormal in patients with underlying heart disease or those who have abnormalities on surface electrocardiogram. The most common abnormality found on electrophysiologic studies is inducible ventricular tachycardia. Upright tilt testing has been used to induce vasovagal syncope in patients with syncope of unknown cause. A positive response has been found in 26% to 87% of patients undergoing this type of testing. The specificity of this test needs to be further investigated. In patients with recurrent syncope of unknown cause, psychiatric evaluation should also be pursued for illnesses such as generalized anxiety disorder, panic disorder, somatization, and major depression. <h3>Conclusions.</h3> —A directed approach to the evaluation is possible using the studies on diagnostic testing of syncope. (<i>JAMA</i>. 1992;268:2553-2560)
THE ILLNESS OF KING EDWARD.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Identifying human biomarkers of nausea for refining animal studies on emesis
Authors: K. Ng, Y. Chua, V. F. Ban, M. Gresty, S. Coen, G. Sanger, S. Williams, G. Barker, P. Andrews, Q. Aziz
Journal: Gut (2011)

<h3>Introduction</h3> The lack of objective biomarkers to assess nausea and susceptibility in humans makes clinical decisions difficult. Furthermore, animal studies unable to identify nausea well is potentially an animal welfare issue. We aim to study the psychophysiological and brain processing response to a novel method of nausea induction. <h3>Methods</h3> 10-min video inducing motion sickness and control were used (51 healthy volunteers; age 27 ± 8 years, 22 male) with tests of motion sickness and psychological questionnaires; cardiac sympathetic (cardiac sympathetic index CSI, heart rate HR, mean blood pressure MBP) and parasympathetic (cardiac vagal tone CVT, cardiac sensitivity to baroreceptor reflex CSB) measures; cortisol levels and electrogastrogram (EGG). 9 susceptible subjects had same stimuli again (age 25 ± 5 years, 5 male) with functional MRI analysed with XBAM. <h3>Results</h3> All subjects completed without vomiting. Comparing nausea video (NA) to control, NA increased nausea (nausea VAS +57%±11, p&lt;0.01). Furthermore, NA raised sympathetic (HR +4.04±0.94, p&lt;0.01; SBP +2.4±1.75, p=0.18; DBP +2.23±0.98, p&lt;0.05; MBP +2.28±1.12, p&lt;0.05) and lowered parasympathetic activity (CVT −1.36±0.49, p&lt;0.01; CSB −1.27±0.61, p&lt;0.05); raised dominant frequency (EGG 3.0±0.04 vs 2.8±0.05, p&lt;0.02). Comparing nausea susceptible versus resistant, moderate to severe nausea lowered CVT and CSB; raised HR; raised cortisol; reduced EGG dominant power (% change from baseline −20.6±7.7 vs −11.2±0.8, p&lt;0.01; −25.1±9.4 vs 8.2±10.7, p&lt;0.05; 10.4±3.4 vs 0.8±2.2, p&lt;0.05; 16.9±20.2 vs −28.5±4.9, p&lt;0.05; −2.81±1.36 vs −0.17±0.93, p&lt;0.01, respectively). 9 susceptible subjects (fMRI) comparing nausea video to control, show correlations to nausea levels with raised brain activity in the inferior frontal gyrus (p&lt;0.01) and temporal lobe (p&lt;0.01) and reduced brain activity in multiple areas of the occipital lobe (p&lt;0.01) and cerebellum (p&lt;0.05). <h3>Conclusion</h3> This model is safe and effective. Nausea susceptible subjects show lowered CVT and CSB; raised HR; raised cortisol; reduced dominant power on EGG from baseline compared to resistant subjects. Nausea susceptible show different brain processing patterns in the NA compared to control. These biomarkers can then be used for reverse translation in animals to potentially improve animal models as well as reduce animal suffering from undetected nausea.
Diagnostic accuracy of acoustic radiation force impulse elastography for the staging of hepatic fibrosis in non-alcoholic fatty liver disease: a systematic review and meta-analysis
Authors: Emmanuel Selvaraj, Hadi Zamarfand, Ferenc Mozes, Arjun Jayaswal, Christina Levick, Naaventhan Palaniyappan, Chang-Hai Liu, Guruprasad Aithal, Manuel Romero Gomez, Stefan Neubauer, Stephen Harrison, Quentin Anstee, Patrick Boussy, Michael Pavlides
Journal: Journal of Hepatology (2020)
The Pocket Gray, or Anatomist's Vade-Mecum.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BERLIN LETTER.
Authors: None N.
Journal: JAMA (1885)

Berlin, Germany, Jan. 10, 1885. <h3>Mr. Editor:</h3> —The method of cultivating bacteria by the solid culture media, which is at present so largely occupying the attention of bacteriologists, particularly on the continent, is deserving of especial attention. I feel the more liberty to say this now,and to explain the method a little in detail, because, like many others of my countrymen, I had a prejudice in favor of liquid cultures, especially when made in hermetically sealed bulbs, which I had used for several years previous to my coming to Germany. I soon saw, however, that I had not fully understood the method of solid cultures, and that my objections, chiefly of the danger of the entrance of impurities, were more theoretical than practical, and that this method, on the other hand, does possess many special advantages,—for in no other way can a mixture of different forms of germs be so
TUBERCULOSIS IN A DESTROYER
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
2000 Gairdner Foundation International Awards
Authors: M. F. Goldsmith
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Jejunal ulceration. Report of a case apparently associated with potassium gluconate
Authors: O. S. Warr
Journal: JAMA (1967)

SINCE the report of Baker et al<sup>1</sup>in November 1964, physicians have been alert to the possibility of patients receiving potassium therapy developing small-bowel ulcerations. Nearly all reports have emphasized the role of enteric-coated potassium chloride as the cause of such lesions. This has made many physicians believe that aqueous solutions of potassium may be given without the danger of such a complication. Therefore, it seems appropriate to report our experience with a patient who developed an acute obstructing ulcer of the jejunum while receiving potassium gluconate (Kaon Elixir). <h3>Report of a Case</h3> A 67-year-old chronic alcoholic, very obese, white woman was admitted to the hospital on the evening of Jan 5, 1966, because of nausea, vomiting, epigastric pain, cough, dyspnea, and nervousness. Her alcohol and weight problem began at least 30 years previously. Roentgenographic studies in the past had demonstrated a diverticulum of the duodenum, a small hiatal
Dementia
Authors: Esther S. Oh, Peter V. Rabins
Journal: Annals of Internal Medicine (2019)

Alzheimer disease (AD) and other dementia syndromes are becoming more common; an estimated 5.5 million adults aged 65 years or older are living with AD in the United States. It is important for primary care physicians to gain knowledge in this field because most community-dwelling older adults receive their care from them. This article discusses the latest findings in approaches to prevent cognitive decline as well as dementia screening, diagnosis, and treatment. Approaches to address quality of life for persons with dementia and their caregivers are also discussed.