tbuckley/cabot-search huggingface dataset:
Benign intracranial hypertension in an adult after tetracycline therapy
Authors: J. Koch-Weser
Journal: JAMA (1967)

BENIGN intracranial hypertension is a well-recognized complication of therapy with tetracycline and its derivatives in infants.<sup>1-9</sup>This condition manifests itself by bulging fontanelles and occasionally by spreading of sutures. Irritability, drowsiness, feeding disturbances, and vomiting are common symptoms, but the child may be asymptomatic. The results of the neurological examination are usually normal and there are no changes in the cerebrospinal fluid. The mechanism of this reaction remains quite obscure. It has not been associated with other manifestations of abnormal reactivity to tetracycline. No relationship has become apparent between the occurrence of tetracycline-induced benign intracranial hypertension and tetracycline dosage or length of therapy. The complication has appeared after five hours to four days of tetracycline treatment. Cessation of tetracycline administration has been followed by disappearance of all signs of increased intracranial pressure in a few hours to three days, and there have been no sequelae. On three occasions reexposure
Abstract 17693: Metabolic and Hemodynamic Determinants of Progression of Mild to Moderate Aortic Stenosis in Patients With End Stage Renal Disease
Authors: Darae Kim, Chi Young Shim, In Jeong Cho, Hyuk-Jae Chang, Geu-Ru Hong, Geu-Ru Hong, Jong-Won Ha, Namsik Chung
Journal: Circulation (2015)

Background: We aimed to characterize progression of aortic stenosis (AS) with end stage renal disease (ESRD), and to determine metabolic and hemodynamic factors attributing to AS progression. Method:A total of 73 ESRD (50 males, age 72±11 years) on dialysis with mild (n=56) to moderate AS (n=17) were enrolled. Age, sex and AS severity matched control group with eGFR above 60 mL/min/1.73m2 was selected (n=79). Transthoracic echocardiography was performed at baseline and during follow up (48±23 months). Severity of AS was accessed by aortic valve area (AVA) calculated by continuity equations. Acceleration of AS was assessed by annual AVA reduction rate. Accelerated group in ESRD patients was defined as those with the highest quartile of AVA reduction rate. Clinical outcomes included aortic valve intervention, hospital admission due to heart failure, and death. Results: Annual AVA reduction rate was significantly higher in ESRD compared to control group (0.36±1.9 vs. 0.05±0.14 cm2/yr, p&lt;0.01). Significantly more patients from mild AS in ESRD progressed to moderate to severe AS compared to control group (32% vs. 9%, p=0.02), while moderate AS showed similar progression in both group (Figure). Accelerated AS group in ESRD patients had significantly larger left atrial volume Index (LAVI) (p&lt;0.01), larger stroke volume (p&lt;0.01) and higher log PTH (p=0.04) compared to non-accelerated group. In multivariate analysis, LAVI≥42ml/m2 (HR 2.2, 95% CI 1.10-4.80, p=0.04) and higher log PTH (HR 2.9, 95% CI 1.10-8.04, p=0.04) were associated poor clinical outcome even after controlling for age and baseline LDL cholesterol. Conclusion: AS in ESRD progress in more accelerated manner compared to those with normal kidney function, even in mild to moderate AS. Therefore, more frequent follow up with proper risk stratification by assessing hemodynamic and metabolic characteristics, such as LAVI and PTH, may benefit ESRD patients to reduce clinical events.
Blood Flow at Local Level Reported Governed by Intravascular Pressure
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Calcium supplementation and bone mineral density in adolescent girls
Authors: T. Lloyd
Journal: JAMA (1993)

<h3>Objective.</h3> —To evaluate the effect of calcium supplementation on bone acquisition in adolescent white girls. <h3>Design.</h3> —A randomized, double-blind, placebo-controlled trial of the effect of 18 months of calcium supplementation on bone density and bone mass. <h3>Subjects.</h3> —Ninety-four girls with a mean age of 11.9+0.5 years at study entry. <h3>Setting.</h3> —University hospital in a small town. <h3>Interventions.</h3> —Calcium supplementation, 500 mg/d calcium as calcium citrate malate; controls received placebo pills. <h3>Main Outcome Measures.</h3> —Bone mineral density and bone mineral content of the lumbar spine and total body were measured by dual-energy x-ray absorptiometry and calcium excretion from 24-hour urine specimens. <h3>Results.</h3> —Calcium intake from dietary sources averaged 960 mg/d for the entire study group. The supplemented group received, on average, an additional 354 mg/d of calcium. The supplemented group compared with the placebo group had greater increases of lumbar spine bone density (18.7% vs 15.8%;<i>P</i>=.03), lumbar spine bone mineral content (39.4% vs 34.7%;<i>P</i>=.06), total body bone mineral density (9.6% vs 8.3%;<i>P</i>=.05), and 24-hour urinary calcium excretion (90.4 vs 72.9 mg/d;<i>P</i>=.02), respectively. <h3>Conclusions.</h3> —Increasing daily calcium intake from 80% of the recommended daily allowance to 110% via supplementation with calcium citrate malate resulted in significant increases in total body and spinal bone density in adolescent girls. The increase of 24 g of bone gain per year among the supplemented group translates to an additional 1.3% skeletal mass per year during adolescent growth, which may provide protection against future osteoporotic fracture. (<i>JAMA</i>. 1993;270:841-844)
Changing social-sexual patterns in gynecologic practice
Authors: S. Wall
Journal: JAMA (1977)

One hundred randomly selected patients from the outpatient Gynecology Unit of the University of California at San Francisco Medical Center were interviewed to determine current attitudes toward reproductive and sexual roles. Major areas of change apparent in the younger population were a substantial decrease in formal marriage, a reduction in the wish for children, a movement away from oral contraception back to mechanical barrier methods, and an attitudinal shift toward acceptance of a bisexual adaptation. It is important for the practicing physician to be responsive to the life-style pattern present in the new generation of women patients. (<i>JAMA</i>237:565-568, 1977)
ALBUMINURIA DUE TO PALPATION.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Family Practice
Authors: Kenneth W. Whittington
Journal: JAMA (1990)

The 1980s concluded with notable developments in a number of areas that are critical to the advancement of primary care in general—and family practice in particular. Major issues pertinent to family practice last year included passage of Medicare physician payment reform and development of student interest initiatives. Other areas of relevance to family practice are concerns about mandatory generic drug substitution for certain patients and illnesses and improving access to medical care through health insurance. During the past decade, public sentiment has been kindled for some sort of national plan to guarantee universal access to medical care (<i>Wall Street Journal</i>. June 30, 1989:B1).<sup>1</sup>This is a conviction shared by organized family practice, which has proposed a plan designed to ensure universal access to medical services through a combination of employer-provided insurance and expansion of public programs. Employers with fewer than a legislatively specified minimum number of employees would be
Depression; study of 100 cases in a general hospital
Authors: R. O. Poe
Journal: JAMA (1966)

Depression was encountered in 52% of 192 patients during routine psychiatric consultations by residents in a general hospital. The records of the first 100 depressed patients seen were reviewed in detail. Half were found to have depressions precipitated by recent events or the vicissitudes of aging, while the other half, predominantly women, had histories of life-long depressive tendencies. Forty-eight percent had concomitant diagnosed organic disease. Seventeen of the 100 had attempted suicide. The manifestations of depression were varied and often misleading, eg, unexplained pain or fatigue. The authors, on the basis of their experience with such patients in the general-hospital setting, propose that the physician who can recognize depression and who appreciates the role which unacceptable anger, guilt, and injured self-esteem play in its etiology can successfully treat many depressed patients by making use of the doctor-patient relationship.
Protective Immunity Does Not Correlate with the Hierarchy of Virus-specific Cytotoxic T Cell Responses to Naturally Processed Peptides
Authors: Awen Gallimore, Tilman Dumrese, Hans Hengartner, Rolf M. Zinkernagel, Hans-Georg Rammensee
Journal: The Journal of Experimental Medicine (1998)

Infection of C57BL/6 mice with lymphocytic choriomeningitis virus (LCMV) stimulates major histocompatibility complex class I–restricted cytotoxic T cells (CTLs), which normally resolve the infection. Three peptide epitopes derived from LCMV have been shown to bind the mouse class I molecule H-2 Db and to stimulate CTL responses in LCMV-infected mice. This report describes the identity and abundance of each CTL epitope after their elution from LCMV-infected cells. Based on this information, peptide abundance was found to correlate with the magnitude of each CTL response generated after infection with LCMV. Subsequent experiments, performed to determine the antiviral capacity of each CTL specificity, indicate that the quantitative hierarchy of CTL activity does not correlate with the ability to protect against LCMV infection. This report, therefore, indicates that immunodominant epitopes should be defined, not only by the strength of the CTL response that they stimulate, but also by the ability of the CTLs to protect against infection.
Physician attitudes toward applications of computer data base systems
Authors: J. Singer
Journal: JAMA (1983)

To determine the attitudes of internists and surgeons to problems in clinical information management and to the use of a computer data base, a survey of 529 internists and 487 otolaryngologists was conducted. The survey group consisted of a national distribution of academic physicians, private practitioners, and residents. Results of 296 completed questionnaires were analyzed for this report. More than one third of all responders were not satisfied with their ability to keep up with new developments; less than 10% were very satisfied. Ninety percent thought that a computer data base would improve their access to information in the literature, and 85% thought it would improve their practice of medicine. Among internists, randomized control trials (RCTs) were viewed as clearly the most useful source of data. Otolaryngologists indicated that RCTs and patient registries were both very helpful. Most physicians indicated significantly greater preference for literature summary and patient registry features over probability estimation capabilities of a computer data base. Sources of data to be incorporated into a successful data base would be different for systems designed for internists and otolaryngologists. (<i>JAMA</i>1983;249:1610-1614)
Abstract 17344: Increasing Calcium-activated Potassium Current Shortens and Stabilizes Repolarization in Chronic Heart Failure
Authors: Ingrid M Bonilla, Victor Long, Kent Mowrey, Karsten Schober, Raul Weiss, Sandor Gyorke, Cynthia Carnes
Journal: Circulation (2015)

Heart failure (HF) is a chronic disease resulting in abnormal prolongation and instability of ventricular repolarization. IKCa has been suggested to stabilize repolarization in HF as IKca blockade has shown pro-arrhythmic effects in the failing ventricle. We tested the hypothesis that an SK channel (IKCa) agonist CyPPA, would shorten and stabilize ventricular repolarization in HF ventricular myocytes. Methods: A tachypacing - induced 4 month HF canine model was used (LVFS: 15.9 ± 2.5%), and LV midwall myocytes were isolated and compared to normal controls. Action potential duration at 50 (APD50), and 90% (APD90) repolarization and APD instability (beat to beat variability of repolarization, a measure of arrhythmia risk) were measured before and after the application of CyPPA (0.001nM-20uM) in control ventricular, and in 4 months HF ventricular myocytes (n=10-15 per group). Results: In control myocytes, CyPPA shortened action potential APD50 and APD90 in a concentration dependent manner (0.001nM-20uM, p&lt;0.05 vs baseline at 20uM, Figure). In HF myocytes, CyPPA also shortened APD50 and APD90, but at lower concentrations than in controls. Notably, In addition to APD shortening, CyPPA significantly decreased repolarization instability (P&lt;0.05 vs baseline at 1 Hz) in HF. CyPPA did not affect resting membrane potential in either group. Conclusions: HF myocytes are more sensitive to IKCa agonism than control myocytes. An IKCa agonist attenuates electrophysiologic remodeling and stabilizes repolarization in failing ventricular myocytes, suggesting a therapeutic role for this approach in HF.
The permanent artificial heart
Authors: George A. Rogers
Journal: JAMA (1988)

<h3>To the Editor.—</h3> I read with interest the Feb 12 issue of<i>JAMA</i>on the artificial heart. As a psychiatrist, I was disappointed that there was no information on the emotional and psychiatric state of the patients or their families. Nowhere did I see a discussion of the quality of life achieved by these patients or what quality, at what sacrifice, might be achieved in the future. Although I've read in the past that heart transplants often result in disturbed mental states owing to the immunosuppressant drugs needed, I've not seen articles on this recently in the journals. In these days of rising medical costs, rapid technological expansion, and an increasing geriatric population, we must evaluate the human as well as the technological effect of what we do. I would hope future evaluations of such procedures will include evaluations of the patient's mood, cognition, affect, etc, and his or her
Trephining in the Ancient and Modern Aspect.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
VITAMIN A AND ENDOCHONDRAL OSSIFICATION IN THE RAT AS INDICATED BY THE USE OF SULFUR-35 AND PHOSPHORUS-32
Authors: Dominic D. Dziewiatkowski
Journal: The Journal of Experimental Medicine (1954)

The administration of vitamin A to vitamin A-deficient rats resulted in a decreased concentration of inorganic sulfate-sulfur in the serum from a value of 2.5 mg. per cent to 1.8 mg. per cent, the latter being close to the value of 2.0 mg. per cent found in normal rats of the same age. The uptake of sulfate and phosphate by femurs and tibiae of vitamin A-deficient rats was less than that in normal rats of the same age. An increased uptake followed the administration of vitamin A: radioautography indicated that in the case of sulfate, its uptake was particularly increased in the epiphyseal cartilage; an increased uptake of phosphate was particularly evident in the diaphysis immediately adjacent to the epiphyseal cartilage plate. The specific activity of the sulfate-sulfur in the chondroitin sulfate samples isolated from the skeletons of vitamin A-deficient rats fell progressively as the deficiency continued. Following administration of vitamin A, the specific activity approached and exceeded the value given by the sample from the skeletons of normal rats of the same age. A substantial increase was found in the value of the specific activity of the sulfate-sulfur of sulfomucopolysaccharides isolated from skins of vitamin A-deficient rats that had been given vitamin A. Following administration of vitamin A to rats deficient in this vitamin, an increased accumulation of some sulfur-containing material was found in regions of active calcification.
High serum TGFα, TNFα and IL6 correlate with abnormal circadian rhythms in patients with metastatic colorectal cancer (MCC)
Authors: P. F. Innominato, T. Rich, J. Boerner, M. C. Mormont, S. Iacobelli, C. Jasmin, F. Lévi
Journal: Journal of Clinical Oncology (2004)

9650
Control of Moderately Raised Blood Pressure: REPORT OF A CO-OPERATIVE RANDOMIZED TRIAL
Authors: M Barraclough, M Joy, G Macgregor, T Foley, M Lee, C Rosendorff, W Holland, W Cranston, J Administration, Miss Saville, D Bainton, A Cochrane, J Greene, G Kil- Patrick, J Weddell, Mrs Kilpatrick, Mr Sweetnam
Journal: BMJ (1973)

A study was designed to investigate the effect on morbidity and mortality of lowering diastolic blood pressure levels of between 100 and 120 mm Hg to below 100 mm Hg. Fifty-eight men and women, aged from 45-69 years, with blood pressure levels between 100 and 120 mm Hg were matched for age, sex, and blood pressure levels with 58 control patients. The maintenance of diastolic blood pressures at levels below 100 mm Hg was successfully carried out without serious drug side effects. Treatment effectively maintained diastolic pressures below 100 mm Hg, but no effect was shown on other terminating events. Few problems were found in the management of patients with minimally raised blood pressure, most of whom were symptom-free. The treatment and control groups became less comparable as increasing numbers of patients in the control group were withdrawn from the trial as diastolic pressures rose above 130 mm Hg.
Subchronic Toxicity of Chlorine Dioxide and Related Compounds in Drinking Water in the Nonhuman Primate
Authors: J. P. Bercz, L. Jones, L. Garner, D. Murray, D. A. Ludwig, J. Boston
Journal: Environmental Health Perspectives (1982)

Subchronic toxicities of ClO2, NaClO2, NaClO3 and NH2Cl were studied in the African Green monkeys (Cercopithecus aethiops). The chemicals were administered in drinking water during 30-60 days subchronic rising dose protocols. The only unexpected and significant toxic effect was elicited by ClO2; this chemical inhibited thyroid metabolism in the animals at a dose of ca. 9.0 mg/kg/day. A statistically significant decrease of serum thyroxine occurred after the fourth week of exposure to 100 mg/l.concentration. The extent of thyroid suppression was dose dependent in each individual monkey, and was reversible after cessation of exposure. NaClO2 and NaClO3 failed to elicit similar effects in doses up to ca. 60 mg/kg/day. Also, NaClO4 or NH2Cl did not cause T-4 suppression in doses of 10 mg/kg/day. The selective thyroid effect of ClO2 was unexplained and it appeared to be paradoxical since ClO2 was rapidly reduced by the oral and gastric secretions to nonoxidizing species (presumably Cl-). No evidence of thyroid effects were detected in the serum of human volunteers who ingested approximately 1 mg/l. of ClO2 in drinking water as a result of routine use in the community water treatment process. Sodium chlorite induced dose-dependent oxidative stress on hematopoesis, causing decreased hemoglobin and red cell count and increased methemoglobin content. At the same time, serum transaminase (SGPT) levels showed significant subclinical elevation. The hematologic effects of NaClO2 rebounded during exposure indicating compensatory hemopoietic activity taking effect during oxidative stress. Sodium chlorate and chloramine did not induce detectable hematologic changes in the animals.
Findings on host resistance genes for infectious diseases are pointing the way to drugs, vaccines
Authors: J. Stephenson
Journal: JAMA (1996)

EVER-EXPANDING knowledge of human genetics is starting to pay dividends that will help explain why some people exposed to disease-causing pathogens become severely ill while others succeed to varying degrees in fending off sickness. "Infectious disease resistance in humans is clearly polygenic," noted Adrian V.S. Hill, DM, at a recent conference in Vancouver, British Columbia, on "Genetic Susceptibility and Complex Traits," cosponsored by the journal<i>Nature Genetics</i>and the Canadian Genetics Diseases Network. What's more, Hill noted, analysis of candidate genes for such scourges as malaria and tuberculosis appears to be an efficient way to get information about the role of host factors in these diseases and apply such findings clinically in the form of tests for disease susceptibility, drug treatment, and vaccines. <h3>Genetic Trade-offs</h3> Scientists have long known, for example, that the gene that causes hemoglobin S, the abnormal form of hemoglobin found in patients with sickle cell anemia