tbuckley/cabot-search huggingface dataset:
Chemical Treatment of Tumors. VII. Nature of the Hemorrhage-Producing Fraction From &lt;italic&gt;Serratia marcescens (Bacillus prodigiosus)&lt;/italic&gt; Culture Filtrate&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/xref&gt;
Journal: JNCI Journal of the National Cancer Institute (1943)

Chemical Treatment of Tumors. VII. Nature of the Hemorrhage-Producing Fraction From Serratia marcescens (Bacillus prodigiosus) Culture Filtrate Get access J. L. Hartwell, J. L. Hartwell chemist Search for other works by this author on: Oxford Academic PubMed Google Scholar M. J. Shear, M. J. Shear principal biochemist Search for other works by this author on: Oxford Academic PubMed Google Scholar John R. Adams, Jr., John R. Adams, Jr. assistant chemist Search for other works by this author on: Oxford Academic PubMed Google Scholar Adrien Perrault Adrien Perrault technical assistance National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 4, Issue 1, August 1943, Pages 107–122, https://doi.org/10.1093/jnci/4.1.107 Published: 01 August 1943
Parallel 34: Experimental Hepatocarcinogenesis
Authors: Tetsuo Takehara -Grant, Bristol-Meyer Squibb, Yuichi Yoshida, Kunimaro Furuta, Satoshi Ogura, Tomohide Kurahashi, Mayumi Egawa, Shinichi Kiso, Yoshihiro Kamada, Scott Siler, Yuching Yang, Diane Longo, Brett Howell, Paul Watkins, Castro Valley, Ahmed Elshamy, Francis Eng, Erin Doyle, Arielle Klep- Per, Xiaochen Sun, Angelo Sangiovanni, Massimo Iavarone, Massimo Colombo, Robert Schwartz, Yujin Hoshida, Andrea Branch, Meyers-Squibb Schering-Plough, Janssen Roche, Achillion Cilag, Ers-Squibb Roche, Glaxo Smith-Kline, Bristol-Meyers-Squibb Schering-Plough, Glaxo Roche, Bristol-Meyers-Squibb Smith-Kline, Arielle Klepper, Mas- Simo Iavarone, Evi Arfianti, Vanessa Barn, W Haigh, Matthew Yeh, George Ioannou, Narci Teoh, Geoffrey Farrell
Journal: Hepatology (2015)

327Ashowed enhanced mitochondrial translocation of JNK accompanied by an increase in the release of mitochondrial enzymes, such as apoptosis-inducing factor and endonuclease G, into the cytosol, which is indicative of increased mitochondrial dysfunction and subsequent nuclear DNA fragmentation.Finally, in vitro experiments showed that Gab1-deficient hepatocytes were more susceptible to APAP-induced mitochondrial dysfunction and cell death, suggesting that hepatocyte Gab1 is a direct target of APAP-induced hepatotoxicity.Conclusion: Our current data demonstrate that hepatocyte Gab1 plays a critical role in controlling the balance between hepatocyte death and compensatory hepatocyte proliferation during APAP-induced liver injury.Thus, hepatocyte Gab1 would be a potential therapeutic target for APAP-induced liver injury.
Studies in Haemolytic Streptococcus Fibrinolysin, Antifibrinolysin and Antistreptolysin, with Particular Reference to Rheumatic Fever
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Kaposi's sarcoma, vascular permeability, and scientific integrity
Authors: R. C. Gallo
Journal: JAMA (1994)

<h3>To the Editor.</h3> —This letter concerns our laboratory's research on Kaposi's sarcoma (KS), the current state of the art, and our response to criticisms in the article by Dr Witte and colleagues<sup>1</sup>regarding our publication in<i>Science</i>.<sup>2</sup> As those familiar with the field are aware, KS is a unique vascular tumor that occurs frequently in human immunodeficiency virus (HIV)—infected patients. The disease remains relatively difficult to treat and is associated with significant morbidity, particularly in its pulmonary, gastrointestinal, and disseminated forms. In 1986, initially looking for an associated virus, we were able to grow cells from KS patients that we believe are vascular endothelial in origin and play a role in establishing the tumor. Using these cells, we have developed the hypothesis that cytokines and the HIV regulatory protein Tat promote the growth of KS cells. The fact that these KS cells are not unique to KS lesions
Mortality among Benzene-Exposed Workers in China
Authors: Richard B. Hayes, Song Nian Yin, Mustafa Dosemeci, Gui Lan Li, Sholom Wacholder, Wong Ho Chow, Nathaniel Rothman, Yao Zu Wang, Tan Rong Dai, Xin-Jie Chao, Zhong Lian Jiang, Pei-Zheng Ye, Hong Bin Zhao, Qing Rui Kou, Wan You Zhang, Juan Fei Meng, Jie Sheng Zho, Xia Fang Lin, Cheng Yu Ding, Chin Yang Li, Zhi-Nan Zhang, De Gao Li, Lois B. Travis, William J. Blot, Martha S. Linet
Journal: Environmental Health Perspectives (1996)
MEDICAL JOURNALISM
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Vascular cell adhesion molecule-1 mediates lymphocyte adherence to cytokine-activated cultured human endothelial cells [published erratum appears in Blood 1990 Dec 1;76(11):2420]
Authors: TM Carlos, BR Schwartz, NL Kovach, E Yee, M Rosa, L Osborn, G Chi-Rosso, B Newman, R Lobb, M] Rosso M$[corrected to Rosa
Journal: Blood (1990)
Cocaine and traffic accident fatalities in New York City
Authors: Narsipur V. Ravi, Edward Hines, William M. Burke
Journal: JAMA (1990)

<h3>To the Editor.—</h3> The study by Marzuk et al<sup>1</sup>concerning the prevalence of recent cocaine use among motor vehicle fatalities in New York City is timely and highlights another major public health consequence of the current cocaine epidemic in the United States. Many of us who care for cocaine-dependent patients, based on the anecdotal evidence of their self-reports, are aware of the reckless driving and other sensationseeking behaviors that can occur after cocaine use. In addition, Robinson et al<sup>2</sup>have demonstrated a negative correlation between substance abuse and seatbelt use. It is important, however, to emphasize the authors' caution that it cannot be construed that drivers killed in motor vehicle accidents who tested positive for cocaine metabolites were impaired immediately prior to the fatal accident. The pharmacokinetic studies that suggest cocaine is eliminated within 48 hours are outdated because they do not reflect the experience observed with
Expression of transforming growth factor alpha in the liver before and after interferon alfa therapy for chronic hepatitis B
Authors: Yosuke Morimitsu, David E. Kleiner, Hari S. Conjeevaram, Chu Chieh Hsia, Adrian M. Di Bisceglie, Edward Tabor
Journal: Hepatology (1995)

The effect of interferon alfa (IFN-α) therapy on the expression of transforming growth factor alpha (TGF-α) in the liver during chronic hepatitis B was investigated. Serial liver biopsy specimens were evaluated from 35 patients who had participated in a randomized, controlled trial of recombinant human IFN-α for the treatment of chronic hepatitis B. Percutaneous liver biopsy specimens obtained before and 1 year after entry in the trial were sectioned and stained with a monoclonal antibody to TGF-α in an avidin-biotin-peroxidase-complex system. The expression of TGF-α in each section was evaluated blindly (with respect to treatment group and order of biopsies) and was numerically scored. There was no significant difference in TGF-α expression before or after therapy between 13 patients receiving daily IFN-α, 13 receiving alternate-day IFN-α, and 9 receiving no therapy. Sustained clearance of HBV-DNA and DNA polymerase activity occurred in 8 of 26 treated patients (“responders”); the 18 other patients were “nonresponders.” Expression of TGF-α before IFN-α therapy was significantly higher in responders than in nonresponders; after IFN-α therapy, TGF-α expression decreased significantly among responders compared with nonresponders and untreated controls. Thus, the level of expression of TGF-α in the liver, which was correlated with the severity of inflammation in the liver in this study, appeared to be predictive of the response to IFN-α therapy in chronic hepatitis B, with a higher level of expression indicating a greater likelihood that the patient would respond. (Hepatology 1995; 22:1021-1026.).
Hyperglyceridemia in coronary artery disease and its management
Authors: P. T. Kuo
Journal: JAMA (1967)

Different laboratory and metabolic studies were used to obtain an etiologic classification of hyperlipidemia in 286 patients with atherosclerosis. The studies showed that although time-consuming metabolic studies were required to clearly establish the nature of the basic disturbance, useful information could usually be obtained by serum lipoprotein analysis (paper electrophoresis) and serum lipid determinations (cholesterol, phospholipid, and triglyceride concentrations). More than 90% of the 286 patients were found to have hyperglyceridemia derived from increased endogenous lipogenesis from carbohydrate. This abnormal carbohydrate sensitivity was revealed with an ad libitum carbohydrate (35% to 40%) diet. Since lipoproteins synthesized from carbohydrates were shown to be rich in both triglyceride and cholesterol, carbohydrate-sensitive hyperglyceridemia was frequently found in association with hypercholesteremia. The abnormal metabolism was controlled by a sugar-free diet, with a carbohydrate allowance of 125 to 150 gm supplied as starches.
Micromyomas of the Uterus with Severe Menorrhagia: A Syndrome
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Transactions of the American pediatric Society, 5th Session, held at West Point, N. Y., May 24, 25 and 26, 1893.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE MAIN FACTORS IN TYPHOID INFECTION
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Screening Mammography
Authors: Walter O. VomLehn
Journal: JAMA (1991)

<h3>To the Editor. —</h3> I care for women at public health department family planning and cancer screening clinics. "Screening Mammography: A Missed Clinical Opportunity?"<sup>1</sup>explored the reasons why screening mammography has been underutilized among less educated and poorer women. My experience has been at variance with the statement that "few cited cost or radiation as reasons for not obtaining a mammogram." Most of my patients want the recommended mammography, but the majority explain that they are unable to do so because they cannot afford it. For these women of "the working poor," any health problem in their family represents a potential financial disaster. For most, a screening mammogram would be an unthinkable luxury.
Waterborne Giardiasis
Authors: PATRICK G. BRADY
Journal: Annals of Internal Medicine (1974)

We studied a case of giardiasis involving an otherwise healthy 44-year-old woman who had not traveled extensively. Epidemiologic investigation showed that the source of infection was water stored in an underground cistern. A survey of nine of the patient's relatives showed four additional individuals with giardiasis. The only common source of exposure was the contaminated cistern. This is the second documented report of waterborne spread of this disease.
Drug Testing
Authors: Arthur A. Hellbaum
Journal: JAMA (1962)

<h3>To the Editor:—</h3> The following letter was sent to Senator Eastland, Chairman of the Senate Judiciary Committee: "So much propagandized publicity has appeared lately concerning thalidomide, drugs in general, the Food and Drug Administration, new regulations, etc., that perhaps it would not be out of order to present an opinion from one who has worked in this field for many years. For a number of years I have been a Professor of Pharmacology in a school of medicine. Those in this position teach prospective doctors about the reactions of drugs and medicines, including what the drug does in the body, its good as well as undesirable effects, when it should and should not be used, etc. "Thalidomide was being tested as a sedative or substitute for the barbiturates and it had many promising characteristics for this purpose, for it appeared to be nonhabit forming and not addicting. An overdose could
Warm up
Journal: British Journal of Sports Medicine (2001)

Warm upA whiV of the future I was intrigued to read in the press recently, a story based on a new study published by de Boer in the journal, Geology, that in Ancient Greece, the oracle at Delphi was probably in a state of a drug induced trance when advising supplicants.Plutarch, the historian, who was also the high priest at the temple of Apollo in Delphi, describes how the high priestess who spoke the oracles inhaled "sweet smelling vapours" in her chasm under the temple.De Boer and his coworkers discovered that the walls of this chasm or adytum contain volatile gases from the bituminous limestone that lies beneath the temple.The most common of these gases was ethylene, which smells sweet and moreover breathing it often induces a state of euphoria.Sometimes people have a more violent reaction.They become delirious and thrash around-a state that Plutarch also recorded.The high priestess, it seems, was as much a glue sniVer as a guru.It is interesting how attitudes change.What was seen in Ancient Greece as prophecy would today be seen as a social problem.Glue sniYng and other illicit drug use are banes of urban society.In sport, drug use is widespread.Both recreational drugs as well as performance enhancing or ergogenic agents are a commonplace feature of elite competition.We are no longer shocked when athletes are sent home from competition, stripped of their records or medals or stopped
POSTABORTAL OLIGURIA
Authors: WARD M. O'DONNELL
Journal: JAMA (1949)

Renal insufficiency as a complication of pregnancy, and particularly of abortion, has long attracted serious consideration. At necropsy the organs of fatal cases in this group are found with morphologic features in common; and there is a constant relationship between the clinical syndrome and these structural changes. Comparison of this relationship with that resulting from other causes has made possible a more complete explanation of postabortal oliguria. Bywaters and Beall<sup>1</sup>in 1941 activated interest in the clinical-pathologic picture which followed crush injuries sustained in the London air raids. The triad of crushing injury, subsequent renal failure and histopathologic alterations in the kidneys focused the attention of clinicians and pathologists on this disease entity, which they called the crush syndrome. The onset of symptoms 2 follows in the wake of crushing trauma or other precipitating factors with or without evidence of shock. Nausea, vomiting, malaise and abdominal pain are usually
The Placebo Effect
Authors: Herbert Benson
Journal: JAMA (1975)

THE PLACEBO EFFECT is a neglected and berated asset of patient care. As health care delivery systems evolve, it is imperative to recognize the value of the placebo effect so that provisions can be made for its incorporation and proper use. Any health care system that minimizes and fragments the relationship between the physician and the patient will lessen the effects of this asset. Disdain for the placebo effect is the prevalent attitude in medicine today. However, throughout much of the history of medicine, until the 19th century, the placebo effect was the most a physician was able to offer his patients,<sup>1-3</sup>and it was relied on to maintain the physician's reputation. Despite patients' submission to "purging, puking, poisoning, puncturing, cutting, cupping, blistering, bleeding, leeching, heating, freezing, sweating, and shocking,"<sup>3</sup>the doctor or healer managed to retain his respected position throughout the ages. Although medicine has since developed
West Nile Virus Leading Cause of Neuroinvasive Arboviral Disease
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
"Secrets from Sweden'
Authors: H. A. Hein
Journal: JAMA (1982)

SWEDEN has reported remarkably low perinatal mortality rates for many years. The Swedes' apparent superiority in perinatal health has generally been ascribed to their relatively advantaged economic status and healthy, homogeneous "stock." However, little attention has been directed to the Swedish system of providing perinatal health care. Immigration to Sweden in recent years has been substantial, and during the period 1973 to 1976, 8.8% of all births in Sweden occurred to immigrant mothers. These women constituted 6.8% of all women of reproductive age during the years noted.<sup>1</sup>Since, in Sweden, immigrants are less advantaged with regard to income, occupation, and living quarters,<sup>2</sup>one might suspect that these conditions would lead to higher perinatal mortality. Interestingly, the immigrant mothers experienced a slightly lower perinatal mortality than their Swedish counterparts.<sup>1</sup> One conceivable explanation is that foreign mothers constitute a favorably selected group and that this counterbalances the socioeconomic factors