tbuckley/cabot-search huggingface dataset:
Dynamic Metal-Thiolate Cluster Structure of Metallothioneins
Authors: Milan Vasak
Journal: Environmental Health Perspectives (1986)

113Cd-NMR studies have established that vertebrate and invertebrate metallothioneins contain two unique metal-thiolate clusters.However, it proved to be difficult to account theoretically for all features of the 113Cd-NMR spectra.In a reinvestigation of these features using chromatographically homogeneous 113Cd7-metallothionein we have identified a total of seven 113Cd resonances and have confirmed the massive intensity difference among these signals.From the effects of variations in temperature, ionic strength, and magnetic field on one-dimensional 113Cd-NMR spectra and from two-dimensional J-resolved 113Cd-NMR spectrum it was concluded that the seven 113Cd signals are composed of several overlapping multiplets and indicative of a dynamic organization of the metal-thiolate clusters.The same nonrigid structure is also indicated individually by recent two-dimensional correlated (COSY)1H-NMR studies of 113Cd7-metallothionein.While showing 113Cd-1H coupling for 19 ofthe 20 cysteine residues, these studies have evidence for only two "bridging" cysteine ligands of the clusters instead of the expected eight suggesting interferences by metal-thiolate exchange process at the 1H-NMR time scale.Analogous indirect evidence for structural mobility of the clusters comes from EXAFS measurements of Znrmetallothionein and from measurements of the perturbed angular correlation of fy-rays (PAC) emis-sion of 111mCdmetallothionein.Thus, while the EXAFS spectra revealed back-scattering from the thiolate ligands, lattice movents within the cluster is believed to preclude back-scattering from neighboring metals.Similarly, in the PAC time spectra the damping of the major oscillatory component was attributed to inordinately large charge fluctuation in the immediate environment of the ...mCd nucleus.These results are consistent with a nonrigid cluster model in which many of the sulfur-metal bonds are temporary broken and reformed, thus giving rise to a number of interchanging cluster substates of comparable stability and overall structure.
Buruli ulcer in New York City
Authors: S. D. Lindo
Journal: JAMA (1974)

Buruli ulcer, or infection with<i>Mycobacterium ulcerans</i>, is a chronic destructive lesion that is endemic in some parts of tropical Africa, New Guinea, Malaysia, and Australia, but it has not been acquired or transmitted in the United States. We report an example that appeared in a Nigerian physician while he was working in New York City. (<i>JAMA</i>228:1138-1139, 1974)
VOLUPTUARIES OF LEARNING
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Remission of Felty's syndrome with long-term testosterone therapy
Authors: B. M. Wimer
Journal: JAMA (1973)

Three men with Felty's syndrome were treated with long-term testosterone therapy. Two had a full, and one a partial, correction of the neutropenia and a concomitant abatement of tendency to infection. For the two patients with complete correction of the neutropenia, full recovery of neutrophils took 20 and 24 months, respectively, correlating with diminution in splenomegaly. Testosterone may increase stem cell commitment to granulopoiesis, at the same time diminishing lymphopoiesis. It may also exert a weak lympholytic effect.
Dictionary of Physiology and Psychology, Including Many of the Principal Conceptions of Ethics, Logic, Esthetics, Philosophy of Religion, Mental Pathology, Anthropology, Biology, Neurology, Physiology, Economics, Political and Social Philosophy, Philology, Physical Science and Education, and giving a Terminology in English, French, German and Italian.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Evaluating the utility of the QUAL-EC in the clinical care of patients with advanced cancer.
Authors: Anne Wilkinson, Susan Slatyer, Anna K. Nowak, Cathy Pienaar, Anil Tandon, Mark Wallace
Journal: Journal of Clinical Oncology (2017)

e21507 Background: We piloted the Quality of Life at the End of Life (QUAL-E) in Australian palliative care in-patients (N = 52) and demonstrated feasibility, acceptability and face validity. An unexpected finding was the potential for the QUAL-E to prompt psycho-social-spiritual discussion when conducted as an interview, indicating opportunities for enhanced support. We compared a 17-item QUAL-E-Cancer (QUAL-EC) to the Distress Thermometer Screening Tool (DT) and participants’ experience when the QUAL-EC was conducted as an interview. Methods: A cross-sectional, mixed methods design was used. Convenience sampling recruited patients (N = 50) with advanced cancer and a prognosis of less than 12 months from a tertiary hospital. Participants completed the DT, followed by the QUAL-EC which was digitally recorded as an interview. Results: Correlational and thematic analysis found that 39.6% of participants reported severe distress (score ≥ 7) while 40% reported moderate distress (score 4-6) on the DT. Levels of distress significantly correlated with two QUAL-EC domains: symptom control ( r= 0.52, p &lt; 0.001) and preparation for end of life ( r= 0.32, p &lt; 0.05). Qualitative analysis identified six themes: the health care team; family issues; approaching death; worry; coping and QUAL-EC experience. Feasibility: completion of the QUAL-EC ranged from 3-14 minutes (M = 7.37 minutes, SD 3.05 minutes). Acceptability: Participants overwhelmingly found the questions to be clear and did not find the questions hard to understand, hard to answer or stressful. Ninety per cent of participants agreed or strongly agreed that they were glad they took part. Conclusions: Patient distress was associated with either symptom burden or concerns about their family/loved ones. When distress is identified on screening, the QUAL-EC offers good potential for nuanced, versus vague, assessment of globalised distress (e.g., DT) as an aid in targeting patient-centered clinical/psycho-social interventions.
Serological response to syphilis treatment. A new analysis of old data
Authors: S. T. Brown
Journal: JAMA (1985)

One important aspect of the posttreatment evaluation of patients with early syphilis is assessment of serological test results. Using information previously collected from 818 patients in the Early Syphilis Study, we evaluated the seroresponse of people treated for primary or secondary syphilis. We generated curves describing the VDRL titer declines with time. The VDRL titer declined approximately fourfold at three months and eightfold at six months. These observations will allow clinicians to identify treatment failures or reinfections at the earliest possible time during their follow-up. (<i>JAMA</i>1985;253:1296-1299)
Research and stored tissues. Persons as sources, samples as persons?
Authors: B. M. Knoppers
Journal: JAMA (1995)

While the debate surrounding the status of human organs, gametes, embryos, tissues, blood, and cells (property? person? gift? waste?) continues, the issues surrounding the storage and possible current and future uses of such "materials" need to be addressed. The comprehensive and sensitive articles—"Informed Consent for Genetic Research on Stored Tissue Samples" by Clayton et al<sup>1</sup>and "Ethical Aspects of Banking Placental Blood for Bone Marrow Transplantation" by Sugarman et al<sup>2</sup>—epitomize the complexity of the underlying ethical, legal, and social problems. Donors, patients, and research participants everywhere have become "sources."<sup>1</sup>Hence, the need for discussion and clarification. See also pp 1783 and 1786. Even though the article by Sugarman et al<sup>2</sup>seemingly focuses on a narrower topic, the ethical issues raised—ownership, informed consent, privacy, confidentiality, and access— are common to both genetic research and placental blood banking. Moreover, in the screening of placental blood for donation,
Clinical efficacy of a newly developed high-sensitive hepatitis B core-related antigen assay for monitoring hepatitis B virus reactivation
Authors: Takako Inoue, Shigeru Kusumoto, Shintaro Ogawa, Chiharu Ohue, Shintaro Yagi, Katsumi Aoyagi, Yasuhito Tanaka
Journal: Journal of Hepatology (2020)
Acute Myeloid Leukemia
Authors: _ _
Journal: Journal of the National Comprehensive Cancer Network (2008)

Approximately 13,290 people will be diagnosed with acute myeloid leukemia (AML) in 2008, and 8820 patients will die of the disease. As the population ages, the incidence of AML, along with myelodysplasia, appears to be rising. Clinical trials have led to significant treatment improvements in some areas, primarily acute promyelocytic leukemia. However, recent large clinical trials have highlighted the need for new, innovative strategies, because outcomes for AML patients have not substantially changed in the past 3 decades. The NCCN AML Panel has focused on outlining reasonable treatment options based on recent clinical trials and data from basic science, which may identify new risk factors and treatment approaches. These guidelines attempt to provide a rationale for including several treatment options in some categories, as divergent opinions about the relative risks and benefits of various treatment options have surfaced. Updates for 2009 include new clarifications of some treatment recommendations as well as for defining polymerase chain reaction positivity. For the most recent version of the guidelines, please visit NCCN.org
Pay the peers. Utilization review with a team approach and payment of physician reviewers
Authors: B. C. Tom
Journal: JAMA (1976)

IN HAWAII, physicians began efforts to improve quality care for hospitalized patients in 1965. Since then, several statewide studies have revealed that nonpunitive peer review systems are ineffective.<sup>1,2</sup>Realizing this, The Queen's Medical Center in Honolulu (480 beds) revised its utilization review program in September 1973<sup>3</sup>to comply with Public Law 92-603 (professional standards review organizations) and with Titles V, XVIII, and XIX under the Social Security Act. The distinguishing characteristics of our utilization review program are twofold: (1) a team approach, utilizing paramedical staff as well as physicians, and (2) payment for peer review. In an effort to contain costs, our objective is to reduce a patient's length of stay, particularly in the expensive care units. Therefore, high priority is given to analyzing appropriateness of admission, length of stay based on level of care, early diagnosis, proper management, and prompt discharge. Our evaluations focus on facts rather
Walkman Pinna
Authors: Bruce H. Matt
Journal: JAMA (1986)

<h3>To the Editor.—</h3> To the list of modern maladies add one more. A healthy 24-year-old man fell asleep for 30 minutes while wearing the earphones of a portable personal cassette player. The right pinna was pressed against the hard plastic of the speaker, from which the protective foam cuff was missing because of previous damage. On awakening, he noted pain in the pinna and a swelling developed. Aspiration yielded 1.5 mL of clear yellow fluid two days after the incident. Firm pressure and occasional repeated aspiration were required over many days to resolve the seroma.
VAGINAL OVARIOTOMY.
Authors: JOHN MADDEN
Journal: JAMA (1896)

Dr. T. G. Thomas, of New York, performed the first systematic vaginal ovariotomy in February of 1870. Before undertaking the operation he prepared himself by operating eight times upon the cadaver. He placed his patient in the knee-elbow position, secured by the apparatus of Bozeman. He passed a rectal bougie into the bowels for a distance of five inches "to prevent all possibility of the rectum falling into the line of incision," lifted up the perineum and posterior wall with a Sims speculum, seized the fornix vaginæ between the rectum and cervix with a tenaculum, and, with a pair of long-handled scissors, made a longitudinal incision into the culde-sac "with one stroke." The tumor was then seized with a tenaculum, three small cysts ruptured and their contents evacuated, whereupon it was easily drawn into the vagina. The patient was now placed in the dorsal decubitus, the pedicle of tumor ligated
Family practice
Authors: R. E. Rakel
Journal: JAMA (1991)

The specialty of family practice is now 22 years old and has matured to the point that research has become a major priority. An increasing number of family physician investigators are receiving competitively funded research grants. In the past two decades, less than 0.01% of funds made available for research by the National Institutes of Health (Bethesda, Md) have been awarded to family medicine researchers.<sup>1</sup>The establishment of the federal Agency for Health Care Policy and Research offers hope for more funding for primary care research. In spite of negligible federal funding, significant efforts have been made by academic and community-based family physicians to coordinate major research projects. Two outstanding examples are the Ambulatory Sentinel Practice Network at the University of Colorado, Denver, and the Haynes Consortium in Georgia. These research networks are addressing important clinical questions by means of population-based studies that have enrolled large numbers of patients.
ANIMAL EXPERIMENTATION AND THERAPEUTICS.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Role Of Oxidized Low-Density Lipoproteins In The Pathogenesis Of Atherosclerosis
Authors: S Parthasarathy
Journal: Annual Review of Medicine (1992)

CD40 is a cell-surface member of the TNF (tumor necrosis factor) receptor superfamily. Upon activation, CD40 can license dendritic cells to promote antitumor T cell activation and re-educate macrophages to destroy tumor stroma. Numerous agonist CD40 ...Read More
Sipuleucel-T (sip-T)–induced lytic CD8+ T cell responses to target antigens in men with hormone-sensitive and castration-resistant prostate cancer (CRPC).
Authors: Emmanuel S. Antonarakis, David I. Quinn, Adam S. Kibel, Daniel Peter Petrylak, Tuyen Vu, Dwayne Campogan, Nancy N. Chang, Crystal Cummings, James B. Trager, Jason Chinn, Nadeem Anwar Sheikh, Charles G. Drake
Journal: Journal of Clinical Oncology (2016)

e23116 Background: Sip-T is an FDA-approved immunotherapy for patients (pts) with asymptomatic or minimally symptomatic metastatic CRPC. Sip-T is manufactured from autologous peripheral blood mononuclear cells cultured with the immunogen PA2024, a fusion antigen of prostatic acid phosphatase (PAP) conjugated to granulocyte macrophage colony-stimulating factor (GM-CSF). In sip-T–treated pts, antibody and T cell responses to PA2024 and/or PAP correlate with improved overall survival. To further elucidate the mechanism of sip-T–induced immune responses, we evaluated the proliferative and lytic ability of PA2024- and PAP-specific CD8+ T cells. Methods: Mononuclear blood cells were labeled with the membrane dye carboxyfluorescein succinimidyl ester (CFSE) and cultured with PA2024 or PAP. In vitroproliferative and lytic CD8+ (cytotoxic T lymphocyte [CTL]) T cell responses to these antigens were evaluated by flow cytometry. For proliferation, progressive dilution of CFSE was measured; for CTL activity, the loss of intracellular granzyme B (GzB) was assessed. Pt samples were obtained from 2 sip-T clinical trials STAND (NCT01431391) and STRIDE (NCT01981122), hormone-sensitive and CRPC pts, respectively. Results: Six wk after sip-T administration, CD8+ PAP- and PA2024-specific responses were observed (n = 14 pts assessed). The magnitude of PA2024-specific CD8+ proliferative responses was greater than that for PAP-specific responses. CD8+ T cells from a subset of pts who exhibited PA2024- and/or PAP-specific proliferative responses were assessed for lytic ability. After in vitro antigen stimulation, intracellular GzB was significantly decreased compared with a no-antigen control (p < 0.05), in all samples evaluated PA2024 (n = 14) and PAP (n = 13), demonstrating CTL activity. Conclusions: Sip-T induced CD8+ CTL proliferation against the target antigens PAP and PA2024. Moreover, antigen-specific CTL activity provides the first direct evidence that sip-T can induce tumor cell lysis. These antigen-specific CD8+ lytic abilities were observed within 6 wk, suggesting rapidly generated immune responses following sip-T. Clinical trial information: NCT01431391 and NCT01981122.
Books in Brief
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Carcinoma of the Male Breast
Authors: Ishmael A. Jaiyesimi
Journal: Annals of Internal Medicine (1993)

Letters1 May 1993Carcinoma of the Male BreastIshmael A. Jaiyesimi, MD, Aman U. Buzdar, MD, and Merrick A. Ross, MDIshmael A. Jaiyesimi, MDSearch for more papers by this author, Aman U. Buzdar, MDSearch for more papers by this author, and Merrick A. Ross, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-118-9-199305010-00026 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We agree with Dr. LeBlond's recommendation of regular follow-up of male patients with breast cancer, which should include self-examination, physical examination, and an annual mammogram of the contralateral breast. We also concur that the emotional trauma associated with prophylactic mastectomy in men may be less than in women. We disagree, however, with the suggestion of an elective subcutaneous mastectomy of the uninvolved breast at the time of initial diagnosis. Subcutaneous mastectomy involves an inframammary skin incision through which most breast tissue beneath the overlying skin and nipple-areolar complex is removed. This procedure, however, does not eliminate all breast ...References1. Goldman LD, Goldwyn RM. Some anatomical considerations of subcutaneous mastectomy. Plast Reconstr Surg. 1973; 51:501-5. Google Scholar2. Goodnight JE Jr, Quagliana JM, Morton DL. Failure of subcutaneous mastectomy to prevent the development of breast cancer. J Surg Oncol. 1984; 26:198-201. Google Scholar3. Eldar S, Maguid MM, Beatty JD. Cancer of the breast after prophylactic subcutaneous mastectomy. Am J Surg. 1984; 148:692-3. Google Scholar4. Humphrey LJ. Subcutaneous mastectomy is not a prophylaxis against carcinoma of the breast: opinion or knowledge? Am J Surg. 1983; 145:311-2. Google Scholar5. Scheike O. Male breast cancer. 5. Clinical manifestations in 257 cases in Denmark. Br J Cancer. 1973; 28:552-61. Google Scholar Author, Article, and Disclosure InformationAuthors: Ishmael A. Jaiyesimi, MD; Aman U. Buzdar, MD; Merrick A. Ross, MD PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1993Volume 118, Issue 9Page: 749KeywordsBreast cancerBreast tissueEmotionsProphylaxis ePublished: 15 August 2000 Issue Published: 1 May 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...