tbuckley/cabot-search huggingface dataset:
Variability in Aflatoxin-Albumin Adduct Levels and Effects of Hepatitis B and C Virus Infection and Glutathione S-Transferase M1 and T1 Genotype
Authors: Habibul Ahsan, Li-Yu Wang, Chien-Jen Chen, Wei-Yann Tsai, Regina M. Santella
Journal: Environmental Health Perspectives (2001)

Exposure to aflatoxin B1 (AFB1), an important cofactor in the etiology of hepatocellular carcinoma in Taiwan, is influenced by dietary and other factors. The present study examined the intraindividual variability in AFB1-albumin adducts, the most reliable long-term biomarker of AFB1 exposure, and whether the baseline or follow-up adduct levels and the intraindividual variability in adduct levels are modified by endogenous and environmental factors. The study measured AFB1-albumin adduct levels among 264 healthy male residents of three townships (Hu-Hsi, Ma-Kung, and Pai-Hsa) of Penghu Islets, Taiwan, at two different time points with a median interval of 1.68 years (range 1.00-3.17 years). There was a generalized reduction in the adduct levels, with the median values being 22.1 pmol/mg (range 5.0-355.8 pmol/mg) at time 1 and 14.3 pmol/mg (range 5.0-205.2 pmol/mg) at time 2. This intraindividual variability in adduct levels was inversely associated with the age of subjects and the time interval between the two blood draws. The variability in adduct levels was lower among subjects in Hu-Hsi and Pai-Hsa townships as compared to those in Ma-Kung. No significant association was observed for the intraindividual variability in AFB1-albumin adducts with regard to the season when blood was drawn. There was also no significant association between intraindividual variability and hepatitis B surface antigen, anti-hepatitis C virus (anti-HCV), glutathione S-transferase (GST) M1, or GSTT1 status. In conclusion, we found substantial intraindividual variability in the AFB1 exposure (as determined by AFB1-albumin adducts) in Taiwan, which was probably more likely related to dietary or other environmental influences rather than to endogenous factors (e.g., hepatitis B/C viral infection or GST M1/T1 genetic status).
Mutagenicity of PCBs and Their Pyrosynthetic Derivatives in Cell-Mediated Assay
Authors: Marja Liisa Hattula
Journal: Environmental Health Perspectives (1985)

The mutagenicity of PCBs, Aroclor 1242 and Clophen A60 was studied in a mammalian cell assay using V79 Chinese hamster cells as target cells. The method was used as a direct assay without metabolizing cells and as a cell-mediated assay with 5000 R-irradiated rat fibroblasts as metabolizing cells. A wipe soot sample of a PCB fire was studied in the same assay, and the results showed no mutagenicity of the pure PCBs. However, the wipe sample showed weak mutagenic activity which disappeared when metabolizing cells were used. The chemical analysis of the wipe sample showed tri-, tetra- and pentachlorodibenzofurans in addition to PCBs.
While some correctional facilities go smoke-free, others appear to help inmates to light up
Authors: A. Skolnick
Journal: JAMA (1990)

IF YOU listen to some prison officials, you might believe that what this country really needs is a good 5-cent cigar, at least for its inmates. While acknowledging the trend toward a smoke-free society, a number of prison and jail administrators are providing inmates with tobacco at greatly reduced prices or even free. Jailers in Boston, for example, reward helpful prisoners with cigarettes, and incarcerated minors in New York City are allowed to buy cigarettes at jail commissaries, often at considerable discounts. The corrections departments of at least two states—Illinois and Michigan— even manufacture their own cigarettes to sell to inmates at a fraction of the regular cost. Illinois can sell cigarettes for less than $0.35 per pack by not paying the $0.16 federal tobacco excise tax, a practice the US Bureau of Alcohol, Tobacco, and Firearms says is illegal. In the view of many correctional health care professionals, such
North of England evidence based guidelines development project: guideline for the primary care management of dementia
Journal: BMJ (1998)

Evidence Based Dementia Guideline Development GroupThis guideline aims to provide recommendations to assist general practitioners manage people with all forms of dementia and help their carers.This is a summary version of the full guideline. 1The areas covered were developed in conjunction with the guideline development group.They were felt to reflect areas that were important in daily clinical practice.The guideline is for the management of patients with dementia; although it covers the area of screening instruments, it is not meant to cover the area of differential diagnosis.All recommendations are for general practitioners and apply to patients attending general practice with dementia.The development group assumes that doctors will use their knowledge and judgment in applying the principles and recommendations given below in managing individual patients, since the recommendations may not be appropriate for all circumstances.Doctors must decide to adopt any particular recommendation in the light of available resources and the circumstances of individual patients.Throughout this guideline categories of evidence (cited as I, II, or III) and the strength of recommendations (A, B, C, or D) are as described in previous method papers and the full version of the guideline.
Standing Waves
Authors: Brian W. Christman
Journal: Annals of Internal Medicine (2020)

Ad Libitum21 January 2020Standing WavesBrian W. Christman, MDBrian W. Christman, MDVanderbilt University, Nashville, Tennessee (B.W.C.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M19-0937 Audio Reading - “Standing Waves” Audio. Michael A. Lacombe, MD, Annals Associate Editor, reads “Standing Waves” by Brian W. Christman, MD Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Should be avoided when marching in groupsThe stacked forces grow with the fall of each stepUntil a bridge twists off its mooringAnd falls to the chasm below.My friend was a static waveUntil scotch and smoke increased the amplitudePast the strength of his heart.The rhythm looked like double jump ropesWhipping the same spot of hot pavement.But death is an inexact eraserEven years after consigning his body to flameThere can still be expectation when a door opensThe particle is goneBut the wave remains. Author, Article, and Disclosure InformationAffiliations: Vanderbilt University, Nashville, Tennessee (B.W.C.)Current Author Address: Brian W. Christman, MD; e-mail, brian.[email protected]gov. PreviousarticleNextarticle Advertisement Audio Reading - “Standing Waves” Audio. Michael A. Lacombe, MD, Annals Associate Editor, reads “Standing Waves” by Brian W. Christman, MD Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 21 January 2020Volume 172, Issue 2Page: 104KeywordsFallsHeartMotivation ePublished: 21 January 2020 Issue Published: 21 January 2020 Copyright & PermissionsCopyright © 2020 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Sleepy Interns
Authors: Alfred Kranes
Journal: New England Journal of Medicine (1971)

All of us have had considerable personal experience with sleep — and sometimes with its lack —but more detailed knowledge about it has resulted, in recent years, from numerous electrophysiologic investigations.1 Although the work of the past 15 years has repeatedly expanded our knowledge of sleep phenomena, it has yielded only tantalizing clues to how and why sleep occurs. Simple physiologic observations about various bodily functions during sleep (temperature, blood pressure, basal metabolic rate, urinary output, sweating, etc.) have long been known, but the detailed analyses of the electroencephalographic variations during normal sleep, especially those periods of fast cortical activity, . . .
Society Proceedings.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Software
Authors: Ray van Wolkenten
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Translocation X;Y System for Detecting Meiotic Nondisjunction and Chromosome Breakage in Males of Drosophila Melanogaster
Authors: P. A. Foureman
Journal: Environmental Health Perspectives (1979)

A nondisjunction and chromosome breakage screening system devised by Craymer and modified in our laboratory, involves an X;Y translocation with the short arm of the Y (Ys), marked with the wild type allele of yellow, attached to the distal end of an X (break point 11D) carrying the recessive marker y; and the long arm of the Y chromosome (YL), marked with the dominant locus Bar of Stone (BS), attached to the proximal end of the X. A female tester strain carrying normal chromosomes homozygous for the yellow allele is employed in the mating scheme. Following normal disjunction in the male, all zygotes, which in this case receive aneuploid paternal sex-chromosomes and a normal euploid maternal complement, will die as a result of genetic imbalance. Thus all survivors from this corss can be classified as exceptions arising from: (1) nondisjunction in the female; (2) gross deletion of the paternal X;Y chromosome; (3) complete loss of the paternal X;Y chromosome; or (4) primary meiotic nondisjunction in the male. Results indicate the sensitivity of this scheme for the detection of events induced by x-rays and various chemicals. Positive results have been obtained with the known mutagens EMS and x-radiation.
2011 ACCF/AHA Focused Update of the Guideline for the Management of Patients With Peripheral Artery Disease (Updating the 2005 Guideline)
Authors: Thom W Rooke, Alan T Hirsch, Sanjay Misra, Anton N Sidawy, Joshua A Beckman, Laura K Findeiss, Jafar Golzarian, Heather L Gornik, Jonathan L Halperin, Michael R Jaff, Gregory L Moneta, Jeffrey W Olin, James C Stanley, Christopher J White, John V White, R Eugene Zierler
Journal: Journal of the American College of Cardiology (2011)
Manuel de neurologie.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AMERICAN SOCIETY OF HEMATOLOGY Thirteenth Annual Meeting, 1970, Puerto Rico, December 5-9
Authors: Samuel Rapaport, Ama Motuisky, Dane Boggs, Daniel Bergsagel, John Ultmann, George Brecher, James Linman, P Repeat, Frederick Klipstein, Robert Hiliman, Richard Rosenfield, Herbert Perkins, Robert Lange, Robert Weed
Journal: Blood (1970)
Study of Behavior Therapy in 30 Psychiatric Patients
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Free Papers
Authors: P. De Deyn, J. De Reuck, A. Sharma, B. Vlietinck, W. Deberdt, O. Buunk, J. G. van der Hoeven, M. Frölich, A. E. Meinders, J. Futó, A. Gál, G. Balás, J. C. Raphael, S. Chevret, C. Chastang, F. Bouvet, L. R. Fresno, D. Daga, R. Toro, A. Poullet, C. de la Fuente, M. A. Estecha, J. M. Molina, M. V. De la Torre, J. L. Carpintero, J. Berré, C. Mélot, J. J. Moraine, R. J. Kahn
Journal: Intensive Care Medicine (1996)
HDL Cholesterol Level Predicts Survival in Men After Coronary Artery Bypass Graft Surgery
Authors: JoAnne Micale Foody, Francis D. Ferdinand, Gregory L. Pearce, Bruce W. Lytle, Delos M. Cosgrove, Dennis L. Sprecher
Journal: Circulation (2000)

Background —HDL cholesterol (HDL-C) is an important independent predictor of atherosclerosis, yet the role that HDL-C may play in the prediction of long-term survival after CABG remains unclear. The risk associated with a low HDL-C level in post-CABG men has not been delineated in relation to traditional surgical variables such as the use of arterial conduits, left ventricular function, and extent of disease. Methods and Results —We performed a prospective, observational study of 432 men who underwent CABG between 1978 and 1979 in whom preoperative HDL-C values were available. Baseline lipid and lipoprotein values, history of diabetes mellitus and hypertension, left ventricular ejection fraction, extent of disease, and use of internal thoracic arteries were recorded. Hazard ratios (HRs) were determined in the patients with and without a low HDL-C level, which was defined as the lowest HDL-C quartile (HDL-C ≤35 mg/dL). After adjustment for age, as well as for baseline metabolic parameters and surgical variables just noted, HDL-C corresponded to both overall (HR 0.40, CI 0.20 to 0.83, P =0.01) and event-free (HR 0.41, CI 0.24 to 0.70, P =0.001) survival. Patients with a high HDL-C level (&gt;35 mg/dL) were 50% more likely to survive at 15 years than were patients with low HDL-C level (≤35 mg/dL) (74% versus 57% adjusted survival, respectively; HR 1.72, P =0.005). In addition, HDL-C showed a strong effect on time-to-event survival such that patients with an HDL-C level of &gt;35 mg/dL were 50% more likely to survive without a subsequent myocardial infarction or revascularization (HR 1.42, P =0.02). Conclusions —HDL-C is an important predictor of survival in post-CABG patients. In this study of &gt;8500 patient-years of follow-up, HDL-C was the most important metabolic predictor of post-CABG survival. One third fewer patients survive at 15 years if their HDL-C levels are ≤35 mg/dL at the time of CABG. The measurement of HDL-C provides a compelling strategy for the identification of high-risk subsets of patients who undergo CABG.
Baltimore.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reference Committees 1981 Interim Meeting
Journal: JAMA (1981)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE CEREBROSPINAL FLUID IN PARETIC DEMENTIA.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bryant
Authors: Richard B Weinberg
Journal: Annals of Internal Medicine (2002)

On Being a Doctor5 November 2002BryantRichard B. Weinberg, MDRichard B. Weinberg, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-137-9-200211050-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The most peculiar thing about being fired is that everybody stops talking to you.“It's time for a change,” they told me, and with that, my decade of service as a section head was over.My telephone stopped ringing. My e-mail slowed to a trickle. No one knocked at my door. When I walked down the hallway, those who had lobbied for my downfall slipped guiltily by, the politically prudent—lest the gossip be true—avoided me, and the rest mumbled embarrassed condolences and rushed on to attend to their own problems. So alone in my office, I stewed in a toxic ... Author, Article, and Disclosure InformationAffiliations: Corresponding Author: Richard B. Weinberg, MD, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157; e-mail, [email protected]edu. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 5 November 2002Volume 137, Issue 9Page: 770-771KeywordsComputersEpilepsyFoodInternetLibrariesResidencySaltsTechnicians ePublished: 5 November 2002 Issue Published: 5 November 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...