tbuckley/cabot-search huggingface dataset:
Hemosiderosis in hemodialysis patients. An autopsy study of 50 cases
Authors: M. Ali
Journal: JAMA (1980)

The distribution of stainable iron stores was investigated in various organs of 50 hemodialysis patients with chronic renal disease. Massive iron deposits were found in the liver and spleen. Among 18 patients with severe hepatosplenic siderosis, iron deposits were abundant in the adrenal glands, lymph nodes, and lungs and were sparse in the heart, kidneys, and pancreas. There was an absence or scarcity of stainable iron in bone marrow of 19 patients (38%) with hepatosplenic siderosis. In five of these marrowiron-depleted patients, serum concentrations of ferritin were high. In long-term hemodialysis patients, a variety of factors make massive iron overload of various organs a likely occurrence, severe hepatosplenic siderosis may occur in marrow-iron-depleted patients, and serum ferritin levels in this setting may not always accurately reflect the status of marrow iron store. (<i>JAMA</i>244:343-345, 1980)
Management of Narcotic-Drug Dependence by High-Dosage Methadone HC1 Technique
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Malaria pigment
Authors: Barbara J. Bain
Journal: American Journal of Hematology (2010)

The existence of malaria pigment has been known for well over a century. It was probably first recognized in 1847 by Johann Heinrich Meckel with the connection with malaria being recognized 2 years later by Rudolf Virchow [1]. Dr. George Carmichael Low, writing to Dr. (later Sir) Patrick Manson, during his expedition to St. Lucia in1901 commented “I went the other day to the dispensary and got five malignant malarias. One child had no symptoms but wasting. Blood contained—Crescents, ring forms, pigmented leucocytes, and marked irregularity in size and shape of the corpuscles” [2]. Low later suggested that observing the presence of pigmented leucocytes was useful in the differential diagnosis between malignant malaria and yellow fever when malaria parasites were infrequent [3]. The blood film shown is from a 54-year-old Afro-Caribbean man who acquired Plasmodium faliparum malaria while residing in Uganda. The image demonstrates numerous ring forms of P. falciparum plus neutrophils showing toxic granulation and left shift. In addition, two of the neutrophils contain malaria pigment, Malaria pigment is hemozoin or β-hematin, an insoluble crystalline derivative of heme. The parasite digests host hemoglobin and converts the heme to hemozoin, thus protecting itself from the toxic effects of heme. A century after Low suggested the diagnostic value of malaria pigment, hemozoin was found to retain diagnostic utility since its ability to depolarize light was found to “flag” blood samples that were likely to contain malaria parasites [4].
ENGLAND
Journal: JAMA (1953)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
POLITICIANS WIN TEMPORARILY IN OHIO.
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fecal Occult Blood Tests for Colorectal Cancer
Authors: D. James B. St. John
Journal: Annals of Internal Medicine (1993)

Letters15 March 1993Fecal Occult Blood Tests for Colorectal CancerD. James B. St. John, MD and Graeme P. Young, MDD. James B. St. John, MDSearch for more papers by this author and Graeme P. Young, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-118-6-199303150-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Drs. Singh and Gallo raise several practical concerns about occult blood testing, including the need to restrict diet and medications, to train the staff properly, and to avoid testing after dental extraction, during menstruation, or when hemorrhoids are bleeding. Nonetheless, they are unduly critical of the tests. In most large screening programs, Hemoccult positivity has ranged from 1% to 2.5% [1-3]. The special problem with nonhydrated Hemoccult is not its specificity [3] but its rather low sensitivity for colorectal cancer [1, 2]. Also, the predictive value of a positive test for cancer may be only 10%, but another ...References1. Hardcastle JD, Thomas WM, Chamberlain J, Pye G, Sheffield J, James PD, et al. Randomised, controlled trial of faecal occult blood screening for colorectal cancer. Results for first 107,349 subjects. Lancet. 1989; 1:1160-4. Google Scholar2. Kronborg O, Fenger C, Olsen J, Bech K, Sondergaard O. Repeated screening for colorectal cancer with fecal occult blood test: a prospective randomized study at Funen, Denmark. Scand J Gastroenterol. 1989; 24:599-606. Google Scholar3. Allison JE, Feldman R, Tekawa IS. Hemoccult screening in detecting colorectal neoplasm: sensitivity, specificity, and predictive value. Ann Intern Med. 1990; 112:328-33. Google Scholar4. Young GP, St John DJ. Selecting an occult blood test for use as a screening tool for large bowel cancer. In: Rozen P, Reich CB, Winawer SJ; eds. Frontiers of Gastrointestinal Research. Advances in Large Bowel Cancer: Policy, Prevention, Research and Treatment. Basel: Karger; 1991:135-56. Google Scholar Author, Article, and Disclosure InformationAuthors: D. James B. St. John, MD; Graeme P. Young, MD PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 March 1993Volume 118, Issue 6Page: 472KeywordsAdenomasCancer screeningColorectal cancerDietFlexible sigmoidoscopyGastrointestinal tractHematologic testsHemoglobinHemorrhageSpecificity ePublished: 15 August 2000 Issue Published: 15 March 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Spurious elevation of the platelet count in acute leukemia
Authors: J. O. Armitage
Journal: JAMA (1978)

SYMPTOMS of acute leukemia are usually related to the absence of normal hemopoiesis. Bleeding related to thrombocytopenia and infection secondary to neutropenia are the most serious manifestations. Before the advent of platelet transfusions, bleeding was the most common cause of death in acute leukemia.<sup>1</sup>More recently with the increasing availability of platelet transfusions and the ability to supply HLA-matched platelets, infection has replaced bleeding as the major cause of death.<sup>2</sup>However, for platelet transfusions to have an impact on survival, the presence of thrombocytopenia must be recognized. In the case reported here, the recognition that bleeding symptoms were secondary to thrombocytopenia was delayed because of artifactually elevated platelet counts due to circulating fragments of leukemic cells. <h3>Report of a Case</h3> A 49-year-old farmer in whom leukemia had been diagnosed, had noticed increasing fatigue for six months and had been hospitalized locally one week earlier with pneumonia. His condition
Cardiopulmonary toxicity after three courses of ABVD and mediastinal irradiation in favorable Hodgkin's disease
Authors: P. Brice, J. Tredaniel, J.J. Monsuez, J.P. Marolleau, C. Ferme, C. Hennequin, J. Frija, C. Gisselbrecht, M. Boiron
Journal: Annals of Oncology (1991)
Respiratory Symptoms and Inflammation After a Smoking Ban—Reply
Authors: Daniel Menzies, Brian Lipworth
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PSYCHIATRY MANUAL
Authors: E. A. Bennet
Journal: BMJ (1962)

<h3>Abstract</h3> Public good exploitation has been studied extensively from an evolutionary lens, but little is known about the occurrence and impact of public good exploiters in natural communities. Here, we develop a reverse ecology approach to systematically identify bacteria that can exploit public goods produced during the degradation of polysaccharides. Focusing on chitin – the second most abundant biopolymer on the planet, we show that public good exploiters hinder the growth of degraders and invade marine microbial communities during early stages of colonization. Unlike cheaters in social evolution, exploiters and polysaccharide degraders (cooperators) come together by a process of community assembly, belong to distant lineages, and can stably coexist. Thus, our approach opens novel avenues to interpret the wealth of genomic data through an ecological lens.
Correction: National and regional prevalence of posttraumatic stress disorder in sub-Saharan Africa: A systematic review and meta-analysis
Authors: Lauren C. Ng, Anne Stevenson, Sreeja S. Kalapurakkel, Charlotte Hanlon, Soraya Seedat, Boniface Harerimana, Bonginkosi Chiliza, Karestan C. Koenen
Journal: PLoS Medicine (2020)

[This corrects the article DOI: 10.1371/journal.pmed.1003090.].
Nitrogen dioxide exposure from domestic gas cooking and airway response in asthmatic women
Authors: T P Ng, C S R Seet, W C Tan, S C Foo
Journal: Thorax (2001)

BACKGROUND Previous studies have not found a consistent association between exposure to domestic cooking using gas appliances and exacerbation of asthma. We investigated the immediate airflow response to acute exposure from single episodes of gas cooking, and peak airflow variability from continued exposure to repeated episodes of gas cooking in a group of non-smoking asthmatic women. METHODS Sixteen adult non-smoking women with mild to severe persistent asthma were studied. The acute short term level of nitrogen dioxide (NO 2 ) during gas cooking episodes and the mean exposure to NO 2 from repeated gas cooking episodes were measured over a 2 week period, as well as proxy measures of frequency of cooking on each day and the length of time spent cooking each day. Their asthma status was monitored using peak expiratory flow rates (PEFR) before and after cooking, 2 week self-recorded serial readings of PEFR, respiratory symptom severity score, and use of rescue bronchodilators for acute asthma attacks. RESULTS Cooking was significantly associated with an immediate mean fall in PEFR of 3.4% (p=0.015, paired t test). The acute short term NO 2 level during cooking was significantly correlated with the fall in PEFR ( r =–0.579; p=0.019). The frequency of cooking over a 2 week period was positively correlated with the mean exposure to NO 2 ( r =0.529; p=0.042). Continued exposure to NO 2 over a 2 week period was associated significantly with increased frequency of rescue bronchodilator usage for asthma attacks ( r =0.597; p=0.031). However, it was negatively associated with PEFR variability ( r =–0.512; p=0.051) and respiratory symptom severity score ( r = –0.567; p=0.043), probably due to the masking effects of bronchodilator treatment. CONCLUSIONS Acute short term exposure to NO 2 from single episodes of gas cooking is associated with immediate airflow limitation. Continued exposure from repeated episodes of gas cooking in asthmatic women is associated with greater use of rescue bronchodilators.
THE SERUM TREATMENT OF TUBERCULOSIS.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Editorial: Prepared for a disaster?
Journal: BMJ (1975)

Prepared for a Disaster?The Moorgate tube-train disaster was an incident which created difficulties from every conceivable angle and confirmed many of the problems to be experienced in disaster manage- ment generally.On page 727 the medical staff concerned with the handling of this most unfortunate incident describe some of the problems they encountered.From the outset it was difficult to assess the magnitude of the accident, and particular problems were experienced in gaining access to the casualties.Lighting and ventilation were required in the confined area of the rescue, and the equipment providing these facilities, together with the cutting equipment, generated noise which in turn added to the difficulties of communication underground.In spite of these and many other problems 74 live patients were evacuated in 13 hours, including one who required an on-site amputation to effect her release.An emergency resuscitation area was established on the under- ground platform, and the efficiency of the sorting and re- suscitation by the medical teams was reflected by the fact that only two casualties reaching hospital were dead on arrival and by the absence of airway problems among all those who were alive.
Incorrect Wording
Journal: JAMA (1983)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reticulum Cell Sarcoma of Central Nervous System
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Atonia Gastrica (Abdominal Relaxation).
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Environmental factors influence sex differences in coronary heart disease mortality
Journal: BMJ (2001)

Meningitis in infancy leads to developmental disabilitiesChildren who have meningitis in infancy have a 10-fold increase in the risk of developing permanent severe or moderate disabilities.Bedford et al (p 533) followed up 1717 children aged 5 years who had had meningitis.General practitioners and parents completed questionnaires about the health and development of 1584 children who had had meningitis and 1391 control children.Those in the meningitis group were more likely to have subtle deficits, such as middle ear disease and visual and behavioural problems.There was considerable variation in outcome depending on the age at infection and the causative organism.All children who have had meningitis should be carefully assessed. Post-traumatic stress disorder is a valid and useful diagnosisPost-traumatic stress disorder is a valid and useful diagnosis but it is not the only psychiatric response to trauma.The disorder is associated with high rates of psychiatric comorbidity and impaired social and occupational functioning and has a prevalence of 1%-7.8% in the general population.Mezey and Robbins (p 561) argue that the diagnosis of post-traumatic stress disorder is important for both patients and doctors and that it can be differentiated from other psychiatric diagnoses by biochemical, neuroanatomical, and phenomenological characteristics.Any concerns about the diagnosis in victims of chronic and lifelong trauma could be resolved by further refining the diagnostic criteria.