tbuckley/cabot-search huggingface dataset:
THE ALLEGED HARM FROM PROTEIN IN THE DIET IN CERTAIN DISORDERS
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Study of Paired, Purged Stool Specimens for the Recovery of Entamoeba Histolytica
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cardiovascular reactivity among surgeons: not music to everyone's ears
Authors: L. Morgenstern
Journal: JAMA (1995)

<h3>In Reply.</h3> —We appreciate the insightful comments of the many physicians who took the time and trouble to comment on our study. Although we readily acknowledge the limitations of our methods, we would like to emphasize that this was our initial effort in a field that no one else has attempted to study. We plan to continue this line of research and would like to study a larger and more diverse sample of surgeons (including women as well as different surgical specialists). In addition, interactive videotapes that simulate surgery are now available to be used in place of the cognitive task we used. Whether or not music should be played during surgery is not a simple or clear issue to address. We developed our study because of anecdotal reports suggesting widespread use of music in a myriad of surgical applications. Since the publication of our article, we have received an
The Public Service
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Family Myth and Homeostasis
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Physical Chemistry of Living Tissues and Life Processes as Studied by Artificial Imitation of Their Single Phases.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pulmonary Function Analysis in the Rabbit Following Bronchochallenge to Causative Agents and Mediators of the Acute Byssinotic Response
Authors: Martha P. Bishop, Patricia A. Pilia, William J. Moorman, Sterling K. Ainsworth
Journal: Environmental Health Perspectives (1986)

New Zealand White rabbits were acutely bronchochallenged for 5 min to ascertain airway responsiveness with six potential byssinogenic agents and mediators: 0.1 g/mL cotton dust extract (CDE), 0.1 g/mL cotton bract extract (CBE), 1 mg/mL endotoxin, 1 mg/mL n-formyl methionyl peptide (n-fMet), 10 mg/mL 5-hydroxytryptamine (5-HT), and 1 mg/mL prostaglandin F2 alpha (PGF2 alpha). Methacholine (MC), 10 mg/mL, was used as a control bronchoconstrictor. Clinically objective criteria were established using increases in resistance values compared to those obtained with saline controls. Animals were classified as: mild responders (Mi) = 125-149%; moderate responders (Mo) = 150-199%; or severe responders (S) = greater than 200%. Three of five (2Mo, 1S) rabbits showed increased pulmonary resistance to CDE bronchochallenge, 3/5 (1Mi, 1Mo, 1S) to CBE, 1/5 (Mo) to purified endotoxin, 4/5 (1Mo, 3S) to n-fMet, 3/5 (1Mi, 1Mo, 1S) to 5-HT, and 2/5 (1Mo, 1S) to PGF2 alpha. All five rabbits (1Mo, 4S) responded to MC bronchochallenge. Rabbits responded minimally to saline, the common solvent of all test agents; however, when challenged with methacholine, a known bronchoconstrictor, rabbits showed significant overt symptoms of acute respiratory distress with immediate and substantial increases in resistance over saline controls. CDE, CBE, and n-fMet inhalation challenge resulted in a majority or all animals showing increased resistance. 5-HT contained in CDE and CBE, exhibited similar resistance increases; however, endotoxin, also found in cotton dust, showed little airway reactivity. The rabbit is useful for characterizing changes in pulmonary function parameters seen in the acute byssinotic reaction. This study has demonstrated that bronchochallenge in the rabbit with potential byssinogenic agents (CDE, CBE, endotoxin, and n-fMet) and mediators (5-HT and PGF2 alpha) result in measurable changes in airway function, particularly increased resistance. Since bronchoconstriction is the major clinical manifestation of the acute byssinotic reaction in man and animals, it is likely that bronchoconstriction observed in cotton mill workers may be in part or totally the result of inherent dust constrictor substances or secondarily released mediators.
Epimorphin expression in intestinal myofibroblasts induces epithelial morphogenesis
Authors: Christine Fritsch, Elzbieta A. Swietlicki, Olivier Lefebvre, Michele Kedinger, Hristo Iordanov, Marc S. Levin, Deborah C. Rubin
Journal: Journal of Clinical Investigation (2002)

The formation of the crypt-villus axis during gut ontogeny requires continued reciprocal interactions between the endoderm and mesenchyme. Epimorphin/syntaxin 2 (epimorphin) is a mesenchymal protein expressed in the fetal gastrointestinal tract during villus morphogenesis. To elucidate its role in gut ontogeny, the epimorphin cDNA was transfected, in sense and antisense orientations, into a rat intestinal myofibroblast cell line, MIC 216. To determine the effects of epimorphin on the epithelium, myofibroblasts were cocultured with the Caco2 cell line. Caco2 cells spread in a simple monolayer over antisense-transfected cells lacking epimorphin. In contrast, sense-transfected myofibroblasts induced Caco2 cells to form compact, round clusters with small lumens. These morphologic differences were preserved in Transwell cocultures in which cell-cell contact was prevented, suggesting that epimorphin’s effects were mediated by secreted factor(s). To determine the effects of epimorphin on crypt-villus axis formation in an in vivo model, rat gut endoderm was combined with epimorphin-transfected myofibroblasts and implanted into the chick intracoelomic cavity. The grafts in which epimorphin was overexpressed revealed multiple well-formed villi with crypt-like units, whereas those in which epimorphin expression was inhibited developed into round cystic structures without crypts or villi. Of several potential secreted morphogens, only the expression of bone morphogenetic protein 4 (Bmp4) was increased in the epimorphin-transfected cells. Incubation with noggin partially blocked the transfected myofibroblasts’ effects on Caco2 colony morphology. These results indicate that mesenchymal epimorphin has profound effects on crypt-villus morphogenesis, mediated in part by secreted factor(s) including the Bmp’s.
Examples of Uses of Databases for Quantitative and Qualitative Correlation Studies between Genotoxicity and Carcinogenicity
Authors: S. Parodi, D. Malacarne, M. Taningher
Journal: Environmental Health Perspectives (1991)

In this paper we give some examples of using databases of genotoxicity and carcinogenicity for quantitative and qualitative correlation studies between short-term tests and carcinogenicity. The quality of the databases is obviously important, but one of the major deficiencies of present databases is that they are too small. Using relatively small, different databases, different results can be obtained. With small databases it is difficult to disaggregate data for homogeneous chemical classes or other types of subsets. Using the databases of Gold (carcinogenicity) and Würgler (genotoxicity), we have investigated the carcinogenic potency of genotoxic and nongenotoxic carcinogens for different chemical classes.
MEDICAL STUDY OF CRIME.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SCDT-09. FOCAL ENHANCED DELIVERY OF SYSTEMICALLY ADMINISTERED THERAPEUTIC HUMAN MESENCHYMAL STEM CELLS USING MRI-GUIDED DISRUPTION OF THE BBB WITH FOCUSED ULTRASOUND
Authors: Rawan Al-kharboosh, Nickolas Ellens, Katarina Cheng, Rotman Maarten, Jordan Green, Alfredo Quiñones-Hinojosa
Journal: Neuro-Oncology (2017)

Pre-clinical interventions to the CNS often require direct cranial administration to reach relevant therapeutic concentrations but cranial opening is not always justified. Systemic administration is required yet application is often hindered due to the difficulty in penetrating the blood-brain barrier (BBB). We used MR-guided Focused Ultrasound (MRgFUS) to deliver primary-patient derived mesenchymal stem cells (hMSCs) for the first time in preselected areas of the brain with sub-millimeter precision. MRIgFUS is a revolutionary way to deliver cellular therapy to delicate or inoperable regions obviating the need for invasive surgical intervention. MRgFUS mediates BBB opening when low intensity FUS is applied to brain vasculature containing circulating microbubbles where the oscillation initiates BBB opening at site of FUS pulse. Human MSCs isolated from our patients were injected intracardially in mice as a proof-of-principal delivery system. Under guidance of MRI, 0.4-1MPa in situ pressures at 1 MHz, 1ms bursts and 1Hz pulse repetition frequency of 120 seconds, left hemisphere of mice was sonicated while the contralateral hemisphere served as control. We demonstrate MRgFUS-mediated permeability of BBB. Each animal (n=3) received 3 cavitation parameters ranging from .4-1MPa in situ pressures at 2, 6 and 24hrs. Immunohistochemistry identified hMSC localization on sonicated points. Further analysis showed blood cell extravasation and capillary damage due indices sonicate close together causing a larger sheer force from the fluid stream of injected microbubbles. The consequence is a cavitation pore larger than intended, necessitating further optimization. There were no observed behavioral complications after sonication and no hMSCs localization in non-pulsed regions demonstrating precise localization and no off-target delivery. Hurdles of systemic therapy due to BBB makes access of therapeutics nearly impossible. This study investigates for the first time the utility of FUS to non-destructively permeabilize the BBB by creating a transient pore big enough for hMSC access.
AB0511 Rituximab in rheumatoid arthritis – interim analysis of the non-interventional bridging study:
Authors: A. Krause, P.M. Aries, H.-M. Lorenz, U. Müller-Ladner, J. Kandenwein, J. Wendler
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Objectives</h3> The BRIDGING study collects clinical routine data on the efficacy and safety of rituximab (RTX) in patients suffering from severe active rheumatoid arthritis (RA). <h3>Methods</h3> BRIDGING is a prospective, non-interventional study with a duration of observation of 6 months for each patient and in case of retherapy for another 6 months. Data to be recorded are treatment data, relevant data on the course of RA such as activity scores, pain intensity and adverse events (AE). In total, the documentation of 1,600 patients is intended. <h3>Results</h3> Up to now baseline data of 765 patients are available. 73.2% of the patients are female, 40.3% smoker or ex-smoker. 60.3% had positive anti-CCP antibodies and 73.5% positive rheumatoid factors (RF). The mean age was 60.6 years, the mean baseline DAS28 was 5.3. Patients suffered from RA since 12.9 years in mean. 67.7% of the patients received a pretreatment with DMARD+TNFi, another 6.3% received other biologics. 24.7% received only DMARDs and 1.2% only TNFi. In case of TNFi pretreatment, 54.8% of the patients received one, 34.1% two, 10.2% three and 0.9% four pretreatments. In 328 of the 765 patients with active RA (DAS28&gt;3.2 at baseline) a duration of observation of at least 24 weeks was documented. 286 of these patients were seropositive, 29 seronegative (13 no data). All 328 patients received the first RTX infusion, 323 patients also the second. The dosage was 1000 mg in 97.3% and 97.8% of the patients, respectively. The scores for pain intensity, HAQ and DAS 28 are shown in Table 1 for RF-positive and RF-negative patients. The mean improvement of DAS 28 after 24 weeks was -1.7, even in patients with high BMI (25 kg/m<sup>2</sup> or higher). At week 24, the DAS28 was available for 181 patients: LDA (low disease activity) was achieved in 29.3%, remission in 17.7%; a moderate EULAR response was achieved in 50.3% and a good in 25.4% of the patients. In total, 355 AEs were reported in 183 of the 765 patients incl. 40 serious adverse drug reactions. <h3>Conclusions</h3> Following RTX therapy, improvements of all activity parameters beginning at week 6 with a peak after 18 weeks could be shown in intensively pretreated patients suffering from severe RA. The safety results corresponded to expectations. The study confirms the significant benefit of RA therapy with RTX in daily clinical practice. <h3>Disclosure of Interest</h3> A. Krause Consultant for: Roche Pharma, Speakers Bureau: Roche Pharma, P. Aries Consultant for: Roche Pharma, Speakers Bureau: Roche Pharma, H.-M. Lorenz Consultant for: Roche Pharma, Speakers Bureau: Roche Pharma, U. Müller-Ladner Consultant for: Roche Pharma, Speakers Bureau: Roche Pharma, J. Kandenwein Employee of: Roche Pharma, J. Wendler Consultant for: Roche Pharma, Speakers Bureau: Roche Pharma
Urinary Drainage
Authors: H. Davies, H. Clansey
Journal: BMJ (1964)

appear to overlook one important point.I am referring to the emotional distress and suffering which these patients undergo while they are waiting for the recovery which they may anticipate as the outcome of the " natural history " of their condition.Such suffering is particularly real and distressing in the anxiety, phobic, and depressive reac- tion-types.Cure and recovery are not the only objectives of treatment; relief of dis- tress and suffering is just as important in psychiatry as in other fields of medical prac- tice.The danger of neglecting therapeutic measures such as psychotherapy, medication, environmental changes, etc., because one knows that " natural " recovery will take place in 70% of cases, must at all costs be avoided.One would also like to know how many of the 70% " recovered " because they submitted to the life struggle at a lower level of achievement than might otherwise have been anticipated.-Iam, etc.,
Mortality in childhood Hodgkin's disease. An etiologic clue
Authors: R. W. Miller
Journal: JAMA (1966)

THERE ARE peculiarities in the distribution of Hodgkin's disease with respect to age and sex which must reflect the influence of factors important in the genesis of the disease. MacMahon<sup>1,2</sup>has noted that (1) the age distribution in cases dying of Hodgkin's disease has two modes, the first of which occurs at 25 to 29 years of age, and (2) among 122 children with the disease before 10 years of age, the sex ratio (male:female) was almost 6:1 in contrast to the much lower value of about 1.5:1 for adults. To explore further the sex ratio in childhood and its relation to the age-peak at 25 to 29 years, we have examined US childhood mortality from Hodgkin's disease by<i>single</i>year of age. A dynamic change in rates was observed which has not previously been described. <h3>Methods</h3> Duplicates of punch cards containing information from the death certificates of all
Error in Figure 4
Authors: Karen Heffler, David Bennett, Keshab Subedi
Journal: JAMA Pediatrics (2020)

Sandra E. Juul, MD, PhD; Phuong T. Vu, PhD; Bryan A. Comstock, MS; Rajan Wadhawan, MD; Dennis E. Mayock, MD; Sherry E. Courtney, MD; Tonya Robinson, MD; Kaashif A. Ahmad, MBBS, MSc; Ellen Bendel-Stenzel, MD; Mariana Baserga, MD; Edmund F. LaGamma, MD; L. Corbin Downey, MD; Michael O’Shea, MD; Raghavendra Rao, MD; Nancy Fahim, MD; Andrea Lampland, MD; Ivan D. Frantz III, MD; Janine Khan, MD; Michael Weiss, MD; Maureen M. Gilmore, MD; Robin Ohls, MD; Nishant Srinivasan, MD; Jorge E. Perez, MD; Victor McKay, MD; Patrick J. Heagerty, PhD; Preterm Erythropoietin Neuroprotection Trial Consortium
Genito=Urinary Diseases and Venereal Diseases.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal