tbuckley/cabot-search huggingface dataset:
Abstract 165: Diacylglycerol kinase α Exacerbates Cardiac Injury After Ischemia/reperfusion In Transgenic Mouse Hearts
Authors: Toshiki Sasaki, Yasuchika Takeishi, Tatsuro Kitahara, Yo Koyama, Takeshi Niizeki, Satoshi Suzuki, Isao Kubota
Journal: Circulation (2007)

Background: Activation of the diacylglycerol-protein kinase C (DAG-PKC) cascade has been implicated in cardiac dysfunction after ischemia/reperfusion (I/R). DAG kinase (DGK) terminates DAG signaling by converting it to phosphatidic acid, and thus may act as a regulator of DAG-PKC signaling. It has been reported that α, ϵ, and &amp;#03B6; isoforms of DGK have been identified in the heart. We examined the functional role of DGKα in cardiac injury after I/R. Methods and Results: We generated transgenic mice with cardiac specific overexpression of DGKα (DGKα-TG) using α-myosin heavy chain promoter. Left anterior descending coronary artery was transiently occluded for 30 min and reperfused for 24 hr in DGKα-TG and wild type littermate (WT) mice. After 24 hr, echocardiography was performed, mice were sacrificed, and the hearts were removed. Areas at risk and infarct size were assessed by Evans blue/TTC double staining. Left ventricular chamber dilatation after I/R was more pronounced in DGKα-TG mice than in WT mice (left ventricular end-diastolic dimension: 3.44 +/− 0.41 mm vs. 3.05 +/−0.24 mm, P &lt; 0.01). Left ventricular systolic function was more severely depressed in DGKα-TG mice than in WT mice (left ventricular fractional shortening: 34.3 +/− 3.6% vs. 42.2 +/− 4.0%, P &lt; 0.01). The ratio of infarct size/area at risk at 24 hr after I/R was larger in DGKα-TG mice than in WT mice (17.9 +/− 4.2% vs. 11.3 +/− 3.3%, P &lt; 0.01). The phosphorylation activity of extracellular-signal regulated kinase (ERK) was increased after I/R in WT mouse hearts (2.58 +/−0.52-fold increase, P&lt;0.0001). However in DGKα-TG mice, activation of ERK after I/R was abolished (1.77+/−0.67-fold increase, P&lt;0.01 vs. WT). Conclusion: DGKα exacerbates cardiac injury by inhibiting cardio-protective effect of ERK activation.
Diagnosis of sesame allergy: analysis of current practice and exploration of sesame component Ses i 1 (2S albumin)
Authors: Travis M. Sifers, Sarah Saf, Mary Grace Baker, Christopher S. Knight, Katrina Bakhl, Jacob Daniel Kattan, Hugh A. Sampson, Anna H. Nowak-Wegrzyn
Journal: Journal of Allergy and Clinical Immunology (2019)
To Elisabeth
Authors: Robert H. Palmer
Journal: Annals of Internal Medicine (1997)

Ad Libitum1 October 1997To ElisabethRobert H. Palmer, MDRobert H. Palmer, MDSmithKline Beecham Corp. Collegeville, PA 19426-0989Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-127-7-199710010-00011 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Each morning when I leave the doorAnd, turning, look for you once more,I find your laughing little faceAt its familiar window place.You cannot talk, nor can sound passBetween us, through the double glass.No movement that the eye can see-And yet, how much you say to me!What sense perceives you reaching so?Strange unity! Eternal flowOf replicating chemistryThat's now in you, though still in me.Each one in turn, the river bed,Is shaped-and shapes, with those we wed,the restless current that we bear,The changing heritage we share.Unchanging bell ... Author, Article, and Disclosure InformationAffiliations: SmithKline Beecham Corp. Collegeville, PA 19426-0989Corresponding Author: Robert H. Palmer, MD, SmithKline Beecham Corp., PO Box 5089, 1250 South Collegeville Road, Collegeville, PA 19426. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1997Volume 127, Issue 7Page: 570KeywordsEye movementsMemoryRivers ePublished: 15 August 2000 Issue Published: 1 October 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Clinical medicine meets forensic sciences
Authors: R. Voelker
Journal: JAMA (1994)

LIKE A SLEUTH tracking an elusive killer, Charles Buerk, MD, still questions the death 2 years ago of a 39-year-old stabbing victim. The injury wasn't serious—a mild puncture wound in the left flank. But the victim died unexpectedly in the hospital 2 days later from adult respiratory distress syndrome (ARDS). Buerk, a trauma surgeon and director of surgical education at Orlando (Fla) Regional Medical Center, presented the case and several others at the annual meeting of the American Academy of Forensic Sciences in San Antonio, Tex. They illustrate how clinicians and medical examiners are collaborating to enhance quality assurance and ultimately improve patient care. Buerk recounted clues in the unexplained ARDS death. When the patient arrived at the emergency department within an hour after the stabbing, he was stable, alert, and oriented but his white blood cell count on admission was 30.0×10<sup>9</sup>/L. During repair of a small serosal
The pregnant kidney
Authors: L. B. Berman
Journal: JAMA (1974)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hare's Practical Diagnosis.—Practical Diagnosis. The use of Symptoms in the Diagnosis of Disease.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Selected New Books
Journal: JAMA (1976)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Neural Substrates of Impaired Prosodic Detection in Schizophrenia and Its Sensorial Antecedents
Authors: David Leitman
Journal: American Journal of Psychiatry (2007)

Objective: Individuals with schizophrenia show severe deficits in their ability to decode emotions based upon vocal inflection (affective prosody). This study examined neural substrates of prosodic dysfunction in schizophrenia with voxelwise analysis of diffusion tensor magnetic resonance imaging (MRI). Method: Affective prosodic performance was assessed in 19 patients with schizophrenia and 19 comparison subjects with the Voice Emotion Identification Task (VOICEID), along with measures of basic pitch perception and executive processing (Wisconsin Card Sorting Test). Diffusion tensor MRI fractional anisotropy valves were used for voxelwise correlation analyses. In a follow-up experiment, performance on a nonaffective prosodic perception task was assessed in an additional cohort of 24 patients and 17 comparison subjects. Results: Patients showed significant deficits in VOICEID and Distorted Tunes Task performance. Impaired VOICEID performance correlated significantly with lower fractional anisotropy values within primary and secondary auditory pathways, orbitofrontal cortex, corpus callosum, and peri-amygdala white matter. Impaired Distorted Tunes Task performance also correlated with lower fractional anisotropy in auditory and amygdalar pathways but not prefrontal cortex. Wisconsin Card Sorting Test performance in schizophrenia correlated primarily with prefrontal fractional anisotropy. In the follow-up study, significant deficits were observed as well in nonaffective prosodic performance, along with significant intercorrelations among sensory, affective prosodic, and nonaffective measures. Conclusions: Schizophrenia is associated with both structural and functional disturbances at the level of primary auditory cortex. Such deficits contribute significantly to patients’ inability to decode both emotional and semantic aspects of speech, highlighting the importance of sensorial abnormalities in social communicatory dysfunction in schizophrenia.
Severe, reversible neutropenia during high-dose mebendazole therapy for echinococcosis
Authors: M. H. Levin
Journal: JAMA (1983)

Two patients receiving oral high-dose mebendazole therapy for echinococcosis were found to have severe, reversible neutropenia, apparently due to marrow suppression; platelets and RBCs were also reversibly suppressed in one. High blood levels of mebendazole (239 ng/mL in one patient may have resulted in the neutropenia and several toxic side effects, as well as a striking shrinkage of the patient's pulmonary and liver cysts. Neutropenia with high-dose mebendazole therapy may occur in up to 5% of patients and may be much more common than previously recognized. The WBC count should be monitored frequently during the first several weeks of therapy. Further experience will be needed to determine whether neutropenia is related to mebendazole levels. (<i>JAMA</i>1983;249:2929-2931)
Acute Pancreatitis
Authors: MICHAEL C. GEOKAS
Journal: Annals of Internal Medicine (1972)

Acute pancreatitis varies in intensity, from mild edema to generalized fulminant necrosis. Biliary tract disease, alcoholism, and pancreatic trauma are leading causes, other primary conditions accounting for fewer cases. With its high rate of protein synthesis, the pancreas is a "sack of enzymes," and autodigestion is the most plausible pathogenesis for the tissue injury. The activation and release of pancreatic and lysosomal hydrolases is not well understood. The mode of intracellular trypsinogen activation is unknown, although α-chymotrypsin has been detected in blood, ascitic, and pleural effusions. Fat necrosis, glassy edema, hemorrhagic necrosis, and protein-rich fluid exudation are characteristic. Elevated serum or urinary amylase is the most important diagnostic feature. X-ray examination of the abdomen and chest is helpful. Abdominal paracentesis may be useful if perforation of a hollow viscus is suspected. Serum methemalbumin helps in differentiating the edematous from the hemorrhagic form. "Calcium soaps" formation and the release of glucagon and thyrocalcitonin may account for hypocalcemia. Infusion of crystalloids and colloids, analgesics, and nasogastric suction may now be supplemented by peritoneal lavage in hemorrhagic pancreatitis. Exploratory laparotomy is justified in diagnostically doubtful cases.
Woman passes first hurdle in right to die case
Authors: Z. Kmietowicz
Journal: BMJ (2001)

The right of terminally ill patients for assistance to end their life moved a step closer last week when a woman with motor neurone disease won the battle to have her case reviewed in the high court.Diane Pretty was diagnosed as having the disease in 1999.Now aged 42, she is paralysed from the neck down but is fully mentally competent.She wants to die at home when she chooses but is physically unable to take her own life.On 31 August she won the right to a full judicial review of the director of public prosecution's refusal to guarantee that Mr Pretty would not be prosecuted under the 1961 Suicide Act if he helped to end his wife's life.Her case could be heard within the next month.Under section 2.1 of the act, Mr Pretty could be imprisoned for up to 14 years if he helped his wife to die.Liberty, the human rights organisation that is representing the Prettys, and the Voluntary
Lead Exposure and Neurobehavioral Development in Later Infancy
Authors: Kim N. Dietrich, Paul A. Succop, Robert L. Bornschein, Kathleen M. Krafft, Omer Berger, Paul B. Hammond, C. Ralph Buncher
Journal: Environmental Health Perspectives (1990)

A prospective methodology was used to assess the neurobehavioral effects of fetal and postnatal lead exposure during the first 2 years of life. Lead was measured in whole blood prenatally in mothers and at quarterly intervals in the infant. Prenatal blood lead levels were low (mean = 8.0 micrograms/dL). However, approximately 25% of the study infants had at least one serial blood lead level of 25 micrograms/dL or higher during the second year of life. Multiple regression and structural equation analyses revealed statistically significant relationships between prenatal and neonatal blood lead level and 3- and 6-month Bayley Mental and/or Psychomotor Development Index. However, by 2 years of age, no statistically significant effects of prenatal or postnatal lead exposure on neurobehavioral development could be detected. Data consistent with the hypothesis that a postnatal neurobehavioral growth catch-up occurred in infants exposed fetally to higher levels of lead are presented.
Summary of Three Lectures on Some Affections of the Genitourinary Organs
Authors: M. B. Hill
Journal: BMJ (1889)

passes through the epidermis, gives rise to a certain amount of burning, but produces such an amount of antusthesia that boils may be opened without pain.Carbolic acid appears to have the pQculiar power of irritating either peripheral ends or nerve centres, when applied to them, and also of completely destroying the power of conduction in sensory nerves, without causing any irritation in them.Cresols.-A local ana3sthetic power is also possessed by several bodies allied to carbolic acid, such as para-cresol.'2These sub- stances destroy the sense of pain but they do not destroy tactile sensibility.But carbolic acid coagulates albumen, and tends, like cold, to destroy the part to which it is applied, and causes ulcera- tion.A similar objection applies to a cresol.But there are other substances also allied to carbolic acid, which are free from this objection.The most important of these is certainly cocaine.Cocaine.-When this substance is boiled with water it splits up, yielding methylic alcohol, benzoic acid, and another substance, eegonine.From eegonine cocaine can again be built up by the addition to it of the radicals benzoyl, C6T1, C0, and methyl, CH3.Ecgonine has no local anaesthetic action whatever, and m this it resembles tropine, which is a product of the decomposition of atropine.
Errata
Journal: Journal of Clinical Oncology (2020)

50 2 HDL) /5.5] 1 [(TG 2 15) /25.5] 1 [(Glucose2100)/15.9] 1 [(waist circumference 2 88)/8.8] 1 [(SBP2130)/11.4] 1 [(DBP 2 85) /10.8]It should have read as: [(50 -HDL) /5.5] 1 [(TG 2 150) /25.5) 1 [(Glucose -100) /15.9] 1 [(waist circumference -88) /8.8] 1 [(SBP -130) /11.4] 1 [(DBP -85) / 10.8]This has been corrected as of May 10, 2020.
Prognostic Value of KRAS Mutations in Stage III Colon Cancer: Post-Hoc Analyses of the Petacc8 Phase III Trial
Authors: J. Taieb, J.F. Emile, K. Le Malicot, A. Zaanan, J. Tabernero, E. Mini, G. Folprecht, J.L. Van Laethem, J. Thaler, J. Bridgewater, L. Petersen, E. Van Cutsem, C. Lepage, R. Salazar, P. Laurent-Puig, H. Blons
Journal: Annals of Oncology (2014)
Comparison of Tzanck smear, viral culture, and DNA diagnostic methods in detection of herpes simplex and varicella-zoster infection
Authors: G. T. Nahass
Journal: JAMA (1992)

<h3>Objective.</h3> —To compare Tzanck smears, viral cultures, and DNA diagnostic methods using the polymerase chain reaction (PCR) in detection of herpes simplex virus (HSV) or varicella-zoster virus (VZV) infection in clinically suspected cases. <h3>Design.</h3> —A 12-month trial comparing PCR with viral cultures and Tzanck smears in patients with clinically suspected HSV or VZV infection. <h3>Setting.</h3> —Both ambulatory and hospitalized patients were recruited from a tertiary referral center and the Miami (Fla) Veterans Affairs Medical Center. <h3>Patients.</h3> —Convenience samples of patients clinically suspected to have HSV (n=48) or VZV (n=35). To be included in the final analysis patients needed to have a positive Tzanck smear, viral culture, or PCR result. Patients who were clinically suspected to have HSV but had VZV by viral culture or PCR were analyzed in the VZV group. Similarly, patients who were clinically suspected to have VZV, but had HSV by viral culture or PCR were analyzed in the HSV group. Seventy-seven patients were available for final analysis: HSV (n=30), VZV (n=32), and 15 control cases who did not have evidence of viral infection. <h3>Results.</h3> —For HSV, PCR detected HSV DNA sequences in 73% of stained smears and 83% of unstained smears. For VZV infection, VZV DNA sequences were detected in 88% of stained smears and 97% of unstained smears. Viral DNA sequences were not detected in the 15 control cases. Viral cultures were positive in 83% and 44% of HSV and VZV cases, respectively. The Tzanck smear was positive in 60% and 75% of HSV and VZV cases, respectively. <h3>Conclusions.</h3> —PCR is a reliable method for detecting HSV and VZV DNA sequences from single stained and unstained Tzanck smears. It is clearly superior to viral culture in identifying VZV infection and is equivalent to conventional culture techniques in identifying cases of HSV. (<i>JAMA</i>. 1992;268:2541-2544)
Radiology Course in June
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Contributions to Resident Forum
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Radioactive Risk?
Authors: Mike Mitka
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal