tbuckley/cabot-search huggingface dataset:
Harefuah, Tel-Aviv
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Why monitor peak vancomycin concentrations?
Authors: Alasdair MacGowan, Andy Lovering, Les White, David Reeves, T.A Collyns, B.A Oppenheim, Marc Wysocki, Frank Thomas, Michel Wolff, M de Hoog, J.W Mouton, J.N van den Anker, StephenB Duffull, EvanJ Begg, NigelJ Saunders
Journal: The Lancet (1995)
Evaluating peer reviews. Pilot testing of a grading instrument
Authors: I. D. Feurer
Journal: JAMA (1994)

<h3>Objective.</h3> —To measure the reliability and preliminary validity of a grading instrument for editors to evaluate the quality of peer reviews. <h3>Design.</h3> —The consecutive sample design included 53 reviews of 23 manuscripts. Reviews were systematically assigned to interrater reliability (n=41; power greater than 0.90 to detect a difference of greater than one point) and preliminary criterion-related validity (n=12) subsamples. Content validity was closely examined. <h3>Setting.</h3> —Nonclinical. <h3>Participants.</h3> —Three graders evaluated reliability. One individual examined content validity and two editors tested preliminary criterion-related validity. <h3>Intervention (Instrument).</h3> —Attributes reflecting two basic dimensions, review content and format, were identified and scored (values are possible points/percent contribution): timeliness, 3/21%; grade sheet, 1/7%; etiquette, 1/7%; sectional narratives, 3/21%; citations, 2/14%; narrative summary, 2/14%; and insights, 2/14%. A scoring guide was provided. <h3>Main Outcome Measures.</h3> —Statistical analyses used to test the interrater reliability of the total score included the intraclass correlation coefficient and analysis of variance with the expectation to uphold the null hypothesis. Kendall's coefficient of concordance was used to test preliminary criterion-related validity. <h3>Results.</h3> —The intraclass correlation coefficient was.84 (<i>P</i>&lt;.001) and a lack of difference between mean scores was demonstrated by analysis of variance (<i>P</i>=.46). Content validity was confirmed and preliminary criterion-related validity was indicated (Kendall's coefficient of concordance=.94,<i>P</i>=.038). Conclusions.—The instrument is reliable. Content validation has been completed, and further criterion-related validation is warranted. (<i>JAMA</i>. 1994;272:98-100)
Bert Geoffrey Achong Lawrence ("Laurie") Gordon Brock Gervais Joly Dixon Ronald Vincent Harris Henry Vernon Jones Anne Carmel Marley (nee O'Hanlon) William Gordon Millar Gavin William Milroy Jean Pasmore (nee Calman) Bernard Butts Reiss Kshitindra Nath Sengupta Andrew Charles Sheldon
Journal: BMJ (1997)
The Impact of Medicare's Prospective Payment System on Wisconsin Nursing Homes
Authors: Mark A. Sager
Journal: JAMA (1987)

<h3>To the Editor.—</h3> In the April 3, 1987, issue ofThe Journal, Dr Davis<sup>1</sup>raises questions about our study of Wisconsin's nursing homes under Medicare's prospective payment system, which showed increased hospitalization rates for elderly Medicaid residents and a shift in location of death from hospitals to nursing homes after implementation of the PPS. Dr Davis concludes that the findings represent "flawed methodology" and "utilization of inappropriate data sources" and that "it may be fallacious to attribute the shift in location of death to the initiation of PPS." Dr Davis' major criticism concerns use of the Medicaid-Medicare hospitalization database. This Medicaid cross-over file represents the most reliable source of hospitalization data available. No data source is error free; the question is whether errors occur consistently across time, represent bias, or appear simultaneously with implementation of the PPS. Dr Davis notes that the reported Medicaid hospitalization rates are lower than
Insulin Lispro
Authors: Frits Holleman, Joost B.L. Hoekstra
Journal: New England Journal of Medicine (1997)

The difference in amino acid composition between beef and porcine insulins and human insulin was long thought to be responsible for the immunogenicity of these animal insulins in humans. As a result, much of the effort expended to meet the world's increasing demand for insulin was devoted to the development of synthetic human insulin. However, the introduction of highly purified synthetic human insulin in the early 1980s did not entirely solve the problem of immunogenicity, and the new technology was used instead to change the amino acid structure of human insulin to make it more suitable for subcutaneous administration. This . . .
STATISTICS OF THE STATE BOARD EXAMINATIONS
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The stenting in small arteries study (SISA): Quantitative angiographic results per segment treated Martin J. Schalij, Serge Doucet, Luc Bilodeau, Johan H. C. Reiber, David J. Hilton, Matty C. Vrolix. Leiden University Medical Center, Leiden, The Netherlands, Montreal Heart Institute, Montreal, Canada
Journal: Journal of the American College of Cardiology (2001)
Family Matters
Authors: Jessica W. Tsai
Journal: JAMA Pediatrics (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Shadow Children
Authors: Jack Coulehan
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An epidemic of suicide among physicians on probation
Authors: R. Crawshaw
Journal: JAMA (1980)

IN 1976, the members of the Oregon Board of Medical Examiners grew uneasy with the incidence of suicide among the physicians they had placed under close examination and probation. Since its inception in 1889, the board has acted through its power of licensure as the primary force regulating the medical profession in the state of Oregon. The board is composed of eight members who represent a cross section of the geographic distribution of physicians in the state. Board members are generally appointed by the governor from a list, proposed by the Oregon Medical Association, of physicians who are recognized and respected in their communities. The disciplinary mode of the board is expressed in its powers of probation. When a physician in Oregon is found culpable of professional misconduct of sufficient weight to merit probation, his license to practice is suspended and immediately reinstated, generally for a probationary period of ten
Phase II Trial of Chronomodulated Infusion of High-Dose Fluorouracil and <i>l</i>-Folinic Acid in Previously Untreated Patients With Metastatic Colorectal Cancer
Authors: H. Curé, V. Chevalier, A. Adenis, N. Tubiana-Mathieu, G. Niezgodzki, F. Kwiatkowski, D. Pezet, B. Perpoint, B. Coudert, C. Focan, F. Lévi, J. Chipponi, P. Chollet
Journal: Journal of Clinical Oncology (2002)

PURPOSE: To study tolerability and efficacy of an intensified chronomodulated schedule of fluorouracil (5-FU) and l-folinic acid (l-FA) as first-line treatment of metastatic colorectal cancer, 5-FU was given near individually determined dose-limiting toxicity in a multicenter phase II trial. PATIENTS AND METHODS: One hundred patients (68 men and 32 women, median age 62 years, World Health Organization performance status ≤ 2) with previously untreated and inoperable metastases received chronomodulated daily infusion of 5-FU/l-FA (from 10:00 pm to 10:00 am with peak at 4:00 am). 5-FU dose was escalated from 900 to 1,100 mg/m 2 /d with fixed dose of l-FA at 150 mg/m 2 /d for 4 days every 14 days. RESULTS: 5-FU dose escalation was achieved in 66% of the patients. Grade 3 to 4 toxicities mainly consisted of nausea or vomiting (14% of patients and 1.5% of courses), hand-foot syndrome (38% of patients and 8% of courses), mucositis (26% of patients and 4% of courses), and diarrhea (21% of patients and 2.3% of courses). Objective response rate (ORR) was 41% (95% confidence interval, 31.5% to 50.5%). Twenty patients underwent metastases surgery; among these, 12 had a complete resection. Median progression-free survival was 7 months. Median survival was 17 months; 28% of the patients were alive at 2 years and 18.6% at 3 years. CONCLUSION: The ORR achieved with intensified chronomodulated delivery of 5-FU/l-FA was nearly twice as high as that earlier obtained by our cooperative group using less intensive 5-FU/FA chronotherapy.
THE NATURE AND SIGNIFICANCE OF HEART SYMPTOMS
Authors: J. Mackenzie
Journal: BMJ (1922)

Martin claims to have introduced certain innovations in the techlnique of Caesarean section.Thiis claim seems to me un- justifiable in view of the following considerations.Dr. Martin's communication was made on April 1st, 1921, wlhereas incision through the rectus sheath in abdominal operations was recommended by me in my
Incidence of diabetes among patients with colorectal cancer.
Authors: Simron Singh, Paula Rochon, Geoffrey Anderson, Craig Earle, Hadas Fischer, Peter Austin, Lingsong Yun, Lorraine Lipscombe
Journal: Journal of Clinical Oncology (2014)

3644 Background: Emerging data show an increasingly recognized risk of colorectal cancer (CRC) in patients with type 2 diabetes (DM) likely due to common biologic pathways. Few data are available on DM incidence among patients with CRC. Our objective was to determine whether patients with CRC have a higher incidence of DM compared to those without CRC. Methods: We conducted a population-based retrospective cohort study in Ontario, Canada, using administrative databases comparing the incidence of DM among all CRC patients identified in the Ontario Cancer registry from Jan 1, 2002 to Dec 31, 2011 with an age-matched control population without CRC. We used Cox proportional hazard to study the association. We modeled the effect of CRC on the cause-specific hazard of developing DM and censored subjects at the time of a competing event. Subgroup analysis was performed on patients receiving chemotherapy vs. not, metastatic disease vs. not and colon vs. rectal cancer. Results: We identified 39,707 persons with CRC and 198,535 controls. The mean age was 68 and 48.6% were female. We found an overall DM incidence of 8.7% over a mean follow up time of 4.8 years. On multivariable analysis, the effect of CRC on the instantaneous hazard of the DM incidence varied over time, and thus we estimated instantaneous hazard ratios (IHR) for years 1-5 of follow up. The risk of DM among CRC patients was significantly higher than controls for at least five years post CRC diagnosis. The overall DM incidence was higher in patients with no metastasis (10.6% vs 8.6%, p<0.01), and lower in patients who received chemotherapy (8.0% vs 9.0%, p<0.01). Conclusions: This is among the first study to report an increased DM incidence among CRC survivors. This association may be due to common risk factors rather than a treatment effect, as the risk remains elevated for at least five years post diagnosis. The hazard may be underestimated, as patients with advanced cancer may not be formally diagnosed with DM. These results strengthen our understanding of the common biologic pathway of both diseases and have major implications for survivorship care in patients with CRC. Years since CRC diagnosis IHR (95% CI) of DM (CRC vs. no CRC) 1 1.42 (1.37, 1.47) 2 1.36 (1.32, 1.41) 3 1.31 (1.26, 1.36) 4 1.26 (1.21, 1.31) 5 1.21 (1.16, 1.26)
Clinical features and outcomes of bacterascites in cirrhotic patients: A retrospective, multicenter study
Authors: Beiling Li, Jinjun Chen, Yanhang Gao, Xian-bo Wang, Zhiping Qian, Zhong-ji Meng, Yan Huang, Guohong Deng, Xiaobo Lu, Feng Liu, Hai Li, Xin Zheng
Journal: Journal of Hepatology (2020)
Comparison of Fetal and Adult ABH Antigens by the Quantitative Hemagglutination Technique
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
"IRON AND BLOOD REGENERATION"
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PDTM-24. PILOT STUDY OF CIRCULATING TUMOR CELLS IN PEDIATRIC HIGH GRADE BRAIN TUMORS
Authors: Izhar Batth, Wafik Zaky, Ssu-Hsien Chen, Wilber Huang, Aish Albert, Najat Daw, Jonathan Gill, Soumen Khatua, Shulin Li
Journal: Neuro-Oncology (2018)

BACKGROUNDBrain tumors are the second most common malignancy in children, and are the leading cause of death from childhood cancer. Although significant strides have been achieved in improving survival of most childhood malignancies, the outcome for children with brain tumors has remained poor. Advanced imaging techniques can reduce diagnostic uncertainty, but the need to identify better disease markers is immense and remains unmet. In that regard, analysis of circulating biomarkers is a novel and promising avenue for monitoring disease status. Despite increasing use in tumor research, circulating tumor cells (CTCs) have not been studied in pediatric brain tumor and only scarcely investigated in adult brain tumors. METHOD: Based on previous research showing cell surface vimentin (CSV) as a key surface marker for CTC detection, we developed an automated CSV-based CTC capture method for pediatric brain tumor using the Abnova CytoQuest CR CTC isolation platform. With this platform, we processed PBMCs isolated from whole blood samples through the automated system to trap CSV-positive CTCs on to a chip. Captured cells are then stained for CSV and CD45 before automated scanning and detection to determine CTC yield per sample. RESULT: Ten patients were consented on the study, nine patients (3 high grade glioma, 3 brain stem glioma, 1 pineoblastoma, 1 medulloblastoma, 1 atypical teratoid rhabdoid tumor) had an adequate samples for testing, of those 7 had CTC detected from PBMCs. Our results show that brain tumors patients can and do exhibit CSV+ CTCs. These findings do not distinguish between various types of brain malignancies as evidenced by positive CTC isolation in multiple types of gliomas and embryonal tumors.
Abstract 19104: Impact of the Ross Procedure on Long Term Survival in Adults: A 25-year Single-center Follow-up Study
Authors: Elisabeth Martin, Siamak Mohammadi, Frederic Jacques, Pierre Voisine, Daniel Doyle, Jean Perron
Journal: Circulation (2015)

Introduction: It has been accepted that early and mid-term survival of patients who underwent the Ross procedure is comparable to that of the general population. We reviewed our 25-year experience with the Ross procedure with the aim of defining long-term survival rates and freedom from reintervention. Hypothesis: We assessed the hypothesis that long-term survival following the Ross procedure was comparable to the general population when matched on age and gender. Methods: Between 1990 and 2015, the Ross procedure was performed on 310 consecutive adult patients in a single center. All patients were prospectively added in a dedicated cardiac surgery registry and every patient was included in the analysis. Complete postoperative clinical examination and history were obtained and transthoracic echocardiogram was performed according to a standardized protocol or when clinically indicated. There was no loss to follow-up. Median follow-up duration was 12.4 years and ranged up to 25 years. Approximately 58% of the study population was followed for more than 10 years. Results: The mean age of our cohort was 40.3 years and included 187 (60.3%) male patients. Congenital aortic valve disease was diagnosed in 77.1%. Indications for surgery were aortic stenosis in 64.6%, aortic insufficiency in 23.4% and mixed aortic disease in 12%. There were 4 (1.3%) hospital deaths and 26 (8.4%) late deaths. Survival at 10 and 25 years was 92.5% and 79.7% respectively. Freedom from pulmonary autograft reintervention was 97.5% and 48% at 10 and 25 years. Freedom from homograft-related reoperation was 99.1% and 69.9% at 10 and 25 years. Ross-related reoperation did not reduce long-term survival in our study population. However, compared to the general population, survival rate was significantly lower in patients following the Ross procedure when matched on age and gender. Conclusions: In conclusion, the Ross procedure is associated with excellent long-term survival, regardless of the need for surgical reintervention. However, long-term survival rates are lower in these patients when compared to matched individuals.