tbuckley/cabot-search huggingface dataset:
Increased 8-hydroxy-2?-deoxyguanosine formation in liver tissues of hepatitis B virus X-transgenic mice +Dept. of Virus Research, Max-Planck-Institut f�r Biochemie, Martinsried; #Zentrale Tierversuchsanlage, Ulm and *Dept. of Medicine II, Klinikum Grosshadern, University of Munich, Munich, Germany
Journal: Hepatology (1995)

Hepatitis B virus (HBV) X gene, encoding a pleotropic transactivator of HBx protein, has been associated with the development of hepatocellular carcinoma (HCC). Molecular information on liver-derived HBV variants isolated from HCC among Taiwanese population was studied. Amplification of the HBV X genes of 20 HCC patients in high stringency with HBV specific primers was observed. The resulting amplified HBV X genes were purified and individually-cloned into pUC-T vector. Sequences of the eight liver-derived X gene were aligned and compared with the wild type, the ayw HBV serotype. Results indicate that the HBx protein of variants were found predominantly within the regions of amino acid positions 26–45 in N-terminus, and positions 87, 88, 116, 118, 119, 127 and 144. Sequences from six out of the eight variants were found to be identical. These accumulated sequence mutations among the eight HBx variants were found to coincide within the B-cell epitopes (positions 29–48), particularly in the HBx proline and serine rich (PSR) domain, and the T-cell epitopes regions (positions 116–127). These frequent mutations of HBV variants, rather than subtype-specific polymorphic sites, may be involved in immunoevasion.
Voluntary risks to health. The ethical issues
Authors: R. M. Veatch
Journal: JAMA (1980)

The discovery that health status is affected by personal life-styles and apparently voluntary health risks poses new problems. It has potential impact on clinical practice, health insurance, and theories of health and disease. Five major problems need attention. First, are these health-risk behaviors really voluntary? Five responses are explored: several other models (the medical, psychological, social structural, and multicausal models) all challenge the assumption of voluntary behavior. Second, are some sufficiently in the public interest that they ought to be subsidized? Third, does justice require that persons bear the costs of truly voluntary health risks? Fourth, what policies should apply to cost-saving, health-risk behavior? Finally, does the voluntary health-risks theme make life too rational and calculating? These issues must be dealt with in future health planning and clinical decision making. (<i>JAMA</i>243:50-55, 1980)
An effective mucolytic aerosol in chronic bronchitis
Authors: M. J. Dulfano
Journal: JAMA (1969)

Oxymix is an experimental mucolytic aerosol agent containing ascorbic acid, sodium percarbonate, and copper sulfate which is vitro produces irreversible breakdown of mucin macromolecules. To assess its effectiveness in vivo the drug was given by aerosol to 20 patients with chronic bronchitis, in a single-blind crossover study of three weeks' duration. Administration of the drug was followed by statistically significant improvement in ventilatory tests, increase in sputum volumes, and decrease in sputum "apparent" viscosity. The water content, cellularity, and bacterial content of the sputum remained unchanged. There were no clinical or laboratory signs of toxic reactions in patients who were given oxymix by aerosol.
Abdominal Surgery
Authors: Claude E. Welch
Journal: New England Journal of Medicine (1966)

THIS biennial report on abdominal surgery includes papers that, in the reviewer's opinion, constitute important contributions, and many others that will not be of permanent value, but do indicate to the reader the course of surgical practice and investigation. The material is collected particularly for the clinical surgeon, so that practical considerations are emphasized.Lower Esophagus and CardiaEsophageal Hiatus HerniaA completely acceptable operation for hiatus hernia has not yet been found. Many procedures have their enthusiastic advocates and severe critics. Generally, a satisfactory repair is followed by a good result, though occasionally the symptoms may originate from some . . .
Neuroendocrinology
Authors: Seymour Reichlin
Journal: New England Journal of Medicine (1963)

Neuroendocrine Aspects of Specific Glandular SystemsRegulation of Sexual FunctionIt is obvious that perpetuation of the species depends upon the accurate correlation of externally manifest mating behavior with the internal events of gametogenesis in ovary and testis. The correlation is accomplished by complex neuroendocrine mechanisms involving the brain, the pituitary gland and the sex-steroid hormones. But the role of the nervous system in the regulation of pituitary-gonadal function extends beyond the integration of reproductive cycles and behavior. Neural influences are involved in the timing of puberty, and they determine the direction of sexual differentiation of the pituitary gland into . . .
Proximal Type Epithelioid Sarcoma of the Scrotum: A Source of Diagnostic Confusion That Needs Immediate Attention: Part 2
Authors: Fikret Fatih Onol, Ylören Tandr, Esin Kotiloğlu, Mehmet Bayramiçli, Serdar Turhal, Levent N. Türkeri
Journal: European Urology (2006)
催产素对皮肤衰老的影响
Authors: S.‐Y. Cho, A.Y. Kim, J. Kim, D.‐H. Choi, E.D. Son, D.W. Shin
Journal: British Journal of Dermatology (2019)

皮肤自然衰老是受体内自然因素(如激素)影响,而非受外部因素(如紫外线或吸烟)影响的皮肤衰老。皮肤衰老导致皱纹、皮肤下垂和弹性下降等表现。如同身体的其他部位,皮肤衰老涉及发生细胞老化(一种因为衰老导致的退化)的细胞比例增多。称为皮肤纤维母细胞的老化皮肤细胞有若干不同于未老化细胞的特征,包括具有所谓的衰老相关分泌表型 (SASP)。 催产素 (OT) 是一种神经肽,对身体有很多有益作用,包括防止衰老相关疾病。但是,关于 OT 在皮肤自然衰老中的作用所知不多。 作者们调查了催产素在防止来自不同年龄女性供体的称为正常人真皮纤维母细胞 (NHDF) 的皮肤细胞衰老中的作用。他们发现,OT 抑制了来自年轻而非年老女性供体的 NHDF 中 SASP 引发的衰老。 作者们还得以了解到更多有关 OT 抑制 SASP 的体内过程以及为何它对年轻和年老女性的影响不同的信息。他们的结果显示,催产素可能对防止皮肤衰老有效。
Setbacks and Fissions -- Reconsidering the Scope and Timing of Reform
Authors: J. K. Iglehart
Journal: New England Journal of Medicine (2009)

Encountering surprisingly strong discontent over Democratic proposals for health care reform, which has been registered at town-hall meetings and has energized the Republican opposition, the Obama administration and its allies have suffered a setback in their efforts to move the president's top domestic initiative forward. Now, as Democrats strive to regain some momentum, their party is split over what path to pursue to win enactment of reform legislation. Ultimately, Obama may have to persuade the Democratic majorities in the House and Senate to support a less sweeping plan that is acceptable to its disparate factions. Attracting Republican support for comprehensive . . .
Nosocomial Group A Streptococcal Infections Associated With Asymptomatic Health-Care Workers--Maryland and California, 1997
Journal: JAMA (1999)

Group A Streptococcus (GAS), a common cause of pharyngitis and uncomplicated skin and soft tissue infections, can cause serious invasive infections (including necrotizing fasciitis and streptococcal toxic-shock syndrome [STSS]) and death. Since 1965, at least 15 postoperative or postpartum GAS outbreaks attributed to asymptomatic carriage in health-care workers (HCWs) have been reported. This report describes two nosocomial outbreaks of GAS infection in Maryland and California during 1996-1997; the findings suggest that early infection-control measures that include active surveillance may interrupt transmission and prevent morbidity and mortality.
METHOD OF INFECTION IN TYPHOID IN INFANTS.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A new implant material for use in reconstructive surgical procedures. Surgibone (Boplant)
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Paracrine regulation of melanogenesis
Authors: X.H. Yuan, Z.H. Jin
Journal: British Journal of Dermatology (2018)

Human skin colour is determined mainly by the amount of melanin it contains. Melanin is a brown pigment whose main role is to protect the skin from the damaging effect of ultraviolet rays. Melanin is produced in the skin by melanocytes, which are specialised cells in the outer layer (epidermis). The production of melanin is a complex process called melanogenesis. It is influenced genetically (racial skin type), by ultraviolet exposure and also as a result of skin inflammation such as eczema or psoriasis. This occurs through interaction between melanocytes and surrounding cells both in the epidermis and the supporting tissues underneath (the dermis). These cells secrete many different messenger chemicals (cytokines) which affect melanocyte activity. This is known as a paracrine effect. This article from workers in Yanji, China, reviews the very complex chemical processes that influence melanin pigment production. Melanocyte activity is affected by cytokines derived from adjacent epidermal cells (keratinocytes), from nerve endings in the skin, and from soluble factors diffusing from fibroblasts, cells found in the dermis beneath the melanocytes. In addition, cells involved in skin inflammatory conditions produce various chemicals, e.g. histamine, which affect melanin production. This can lead to the skin becoming lighter or darker in colour after an episode of psoriasis, for example. Thirty‐one chemical messengers involved in regulating pigment production are discussed in this paper. No doubt more will be discovered in the future, adding to the complexity of our understanding of this vital function of the skin.
Expression of laminin and its receptor LBP-32 in human and rat hepatoma cells
Authors: P Rescan
Journal: Hepatology (1991)

Dramatic cellular changes that occur during hepatocarcinogenesis are associated with major alterations in extracellular matrix formation and in the relationships between cells and their microenvironment. We have studied the expression of laminin, the major noncollagenous glycoprotein of basement membrane, and the laminin receptor 32 kD laminin-binding protein in two rat (Faza 967 and HTC) and two human (HepG2 and HBGC2) hepatoma cell lines that express a variety of liver-specific functions. Laminin was found in the rough endoplasmic reticulum of these cells when the indirect immunoperoxidase method and electron microscopic examination were used. Radiolabeled laminin, immunoprecipitated from both media and cell extracts, was resolved by electrophoresis on sodium dodecyl sulfate gel in two major polypeptides that comigrated with the A and B subunits from Engelbreth-Holm-Swarm tumor laminin. Immunoblot analysis showed that the Mr = 400,000 polypeptide did not correspond to the A subunit of laminin. Northern blot analyses demonstrated large amounts of B1 and B2 mRNAs but no A chain mRNA. We conclude that the tumor cells produce the laminin B chains only. In contrast, normal adult hepatocytes from either man or rat lacked laminin mRNAs, whereas in 1-day primary culture, B chain mRNAs became detectable. The steady-state level of 32 kD laminin-binding protein mRNA was 10-fold and threefold higher in rat hepatoma cells than in freshly isolated and 1-day cultured normal rat hepatocytes, respectively. In human hepatocytes, the steady-state levels of 32 kD laminin-binding protein mRNAs varied depending on the donor and never reached the level of the human hepatoma cells. Subsequently, Faza, HTC and HepG2 cells, which were selected for their ability to grow on soft agar, were injected into the flank of nude mice and formed solid tumors with no formation of secondary tumors. The tumors contained laminin in sparse deposits between adjacent cells and accumulated around vessels. None of the hepatoma cell lines studied was found to penetrate a reconstituted basement membrane using a chemoinvasion assay with a Boyden chamber. Our data show that hepatoma cells produce the B chains of laminin and express a high level of receptor 32 kD laminin-binding protein mRNA. However these properties appear to be insufficient for these cells to form metastases in vivo. (HEPATOLOGY 1991;13:289–296).
THE KANSAS LYNCHING.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Metabolic alkalosis.
Authors: B F Palmer, R J Alpern
Journal: Journal of the American Society of Nephrology (1997)

In summary, the kidney possesses numerous mechanisms that help to prevent metabolic alkalosis. Maintenance of metabolic alkalosis for any length of time means that renal homeostatic mechanisms for HCO3- excretion have been disrupted. Understanding the mechanisms that may perturb the kidney's ability to correct alkalosis will lead to improved clinical approaches to differential diagnosis and treatment of the patient. Although metabolic alkalosis is frequently not dangerous, in certain settings metabolic alkalosis may contribute to mortality and should be treated aggressively.
<i>ACE</i> Polymorphisms
Authors: F.A. Sayed-Tabatabaei, B.A. Oostra, A. Isaacs, C.M. van Duijn, J.C.M. Witteman
Journal: Circulation Research (2006)

Angiotensin converting enzyme (ACE) plays an essential role in two physiological systems, one leading to the production of angiotensin II and the other to the degradation of bradykinin. The wide distribution and multifunctional properties of these peptides suggest that ACE could be involved in various pathophysiological conditions. The discovery that ACE levels are under genetic control ushered in a new era of investigation; most studies focused on an insertion/deletion (I/D) polymorphism in intron 16 of the ACE gene as a marker for a functional polymorphism. Recently, many single nucleotide polymorphisms were detected in the gene and the search for the locations of functional polymorphisms became a topic of extensive investigation. Nevertheless, association studies on the I/D polymorphism and clinical outcomes continued, mostly with conflicting results. This article reviews the current state of knowledge regarding ACE polymorphisms and suggests that a functional polymorphism is most likely located between intron 18 and the 3′ UTR. The potential existence of another functional polymorphism in the 5′ UTR, however, cannot be excluded. This review also presents an overview of ACE function in different pathophysiological systems, and summarizes previous reports on ACE and clinical outcomes. Although findings on the I/D polymorphism and disorders like diabetic nephropathy and Alzheimer disease can be considered conclusive, reports on most of the cardiovascular phenotypes are still controversial. Genotypic and phenotypic misclassifications, insufficient power in some studies, and the presence of interaction with other genes or environmental factors are possible explanations for the contradictory findings.
Adaptive Immunity
Authors: T Nghiem-Rao, Alisha Mavis, Elizabeth Polzin, Mary Firary, Grzegorz Telega, Shailendra Patel, Nadine Hermanns, Francisco Cubero, Antje Mohs, Kim Ohl, Malika Al Masaoudi, Christian Liedtke, Klaus Tenbrock, Christian Trautwein, Hyun Lee, Dong-Yeop Hong, Hyung Chang, Eui-Cheol Kim, Kiichiro Kaji, Eishiro Mizukoshi, Tatsuya Yamashita, Kuniaki Arai, Hajime Sunagozaka, Kazumi Fushimi, Hidetoshi Nakagawa, Kazutoshi Yamada, Masaaki Kitahara, Shuichi Kaneko, ; Gastroen- Terology
Journal: Hepatology (2013)

sitosterol, and cholesterol levels in plasma samples obtained in longitudinal fashion while on PN.In addition, we collected laboratory data to determine presence of cholestasis and hepatocellular injury.80 patients were recruited, 56 patients received PN, 23 patients were controls on full enteral feeds, and 1 was excluded due to a genetic duplication.Results: We identified two distinct patters of sitosterol metabolism: fast metabolizers who maintained sitosterol levels below 0.5, slow metabolizes in whom sitosterol levels exceeded 0.5 and usually continued to increase during the study period.We found significant positive correlation between conjugated hyperbilirubinemia and increased sitosterol levels in infants and older children with congenital bowel disease and/or intestinal surgery.Conclusions: There are 2 distinct types of sitosterol metabolism.Intestinal surgery and/or congenital bowel disease is a risk factor for conjugated hyperbilirubinemia in patients who have decreased sitosterol metabolism.
Nosocomial Pseudomonas pickettii bacteremias traced to narcotic tampering. A case for selective drug screening of health care personnel
Authors: D. G. Maki
Journal: JAMA (1991)

Three patients in a university hospital developed nosocomial infusion-related<i>Pseudomonas pickettii</i>bacteremia. Investigation identified six additional patients who had received intravenous fluid contaminated by<i>P pickettii</i>but did not become ill. All nine patients had had surgery, and each of these patients but only nine of 19 operated-on control patients had received intravenous fentanyl citrate in the operating room; the mean dose given to the nine case patients was far greater than that given to control patients. Fentanyl in 20 (40%) of 50 predrawn 30-mL syringes was shown to be contaminated by<i>P pickettii</i>. Contamination was caused by theft of fentanyl from predrawn syringes and replacement by distilled water contaminated by<i>P pickettii</i>. Narcotic theft by health care personnel may cause patients to suffer pain needlessly and can also result in dire unanticipated consequences, such as nosocomial bacteremia. Whereas drug testing in the workplace is highly controversial, we believe that testing of health care personnel is indicated when drug abuse or theft is suspected. (<i>JAMA</i>. 1991;265:981-986)
Evidence Strength in FDA Premarket Approval of Cardiovascular Devices—Reply
Authors: Rita F. Redberg
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sex differences of adipose tissue dynamic changes in NASH progression of morbid obese patients: a preliminary study
Authors: Gerard Baiges, Elisabet Rodríguez-Tomàs, Anna Hernández-Aguilera, Helena Castañé, Salvador Fernández-Arroyo, Montserrat Fibla Simó, Jordi Camps, Jorge Joven
Journal: Journal of Hepatology (2020)
Table of Contents
Authors: Stergios Polyzos, Konstantinos Toulis, Dimitrios Goulis, Christos Zavos, Jannis Kountouras, Grégory Aubert, Virginie Mansuy, Marie-Jeanne Voirol, Luc Pellerin, François Pralong, Jaak Jürimäe, Jarek Mäestu, Toivo Jürimäe, Brent Mangus, Serge Von Duvillard, Hua Li, Jin Sei, Sang Chang, Ki Koh, Yong Kim, So Lee, Jae Ryu, Jong Song, Fábio Santos, Jose Lira, Ronaldo Rosa, Dos Vagner, Daniel Santos, June Paulino Venancio, Priscila Carnier, Lima De, Claudia Sanches, Aline Oller Do Nascimento, Lian De Piano, Sergio Tock, Marco Tufik, Ana Túlio De Mello, Lila Dâmaso
Journal: Metabolism (2011)
Errata
Journal: BMJ (1843)

Oh! do not say that doctor's stuff Could cure my woesome ills; Or thinkthat ever health is foundIn potions or in pills.No noisome draught could bring relief,No drug my fever quell; Health, rosy maid, like Truth, is foundIn the bottom of a well."" 0, Peter dear! fine water'd silks I've often seen, 'tis true; Of watery setting suns I've heard, And watery suchet too.If with a watery lover I Must make myself content, I'll to the Coldstreams go, and choose One from that regiment."