tbuckley/cabot-search huggingface dataset:
Abstract 5267: Unbiased metabolic profiling of atypical teratoid/rhabdoid tumors predicts sensitivity to the glutamine metabolic inhibitor 6-diazo-5-oxo-L-norleucine
Authors: Sabrina Z. Wang, Brad Poore, Jesse Alt, Antoinette Price, Sariah Allen, Brent Orr, Rana Rais, Barbara Slusher, Charles Eberhart, Eric H. Raabe, Jeffrey H. Rubens
Journal: Cancer Research (2019)

Abstract Atypical teratoid rhabdoid tumors (AT/RT) are deadly tumors of infancy in need of new, targeted therapies. Molecular analyses have revealed 3 epigenetically distinct subgroups of AT/RT. High MYC-expressing tumors are a particularly aggressive subgroup, with a 5-year median survival of 18.5%. MYC is difficult to directly target given large, flat, featureless protein-protein binding sites. We performed the first unbiased metabolic profile of AT/RT cell models by high-performance liquid chromatography-mass spectrometry. This study revealed that high MYC-expressing AT/RT have a unique metabolic profile (Partial Least Squares-Discriminant Analysis). Pathway analysis highlights a dependence on glutamine metabolism in high-MYC expressing AT/RT. High MYC-expressing cell lines grow poorly in glutamine-free media compared to low-MYC cell lines (MTS assay, glutamine-free media vs normal media). Due to this dependence on glutamine metabolism, we hypothesized that high-MYC expressing AT/RT would be especially sensitive to glutamine metabolic inhibitors. We show that the glutamine analogue, 6-diazo-5-oxo-L-norleucine (DON) slows high-MYC expressing AT/RT cell growth, induces high rates of apoptosis, and improves survival in orthotopic mouse models of high-MYC expressing AT/RT (p =0.0027 by log-rank test). In contrast, low-MYC expressing models are relatively insensitive to DON. In uniformly labeled glutamine metabolic analyses of AT/RT cells, DON treatment led to depletion of glutathione levels by preventing the production of glutamate. DON treatment synergized with carboplatin to kill AT/RT cells in vitro and extend the life of mice bearing AT/RT orthotopic xenografts (p&amp;lt; 0.001 by log rank test). We aim to translate these findings into a new clinical trial to improve survival in this deadly disease. Citation Format: Sabrina Z. Wang, Brad Poore, Jesse Alt, Antoinette Price, Sariah Allen, Brent Orr, Rana Rais, Barbara Slusher, Charles Eberhart, Eric H. Raabe, Jeffrey H. Rubens. Unbiased metabolic profiling of atypical teratoid/rhabdoid tumors predicts sensitivity to the glutamine metabolic inhibitor 6-diazo-5-oxo-L-norleucine [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 5267.
Differential display and integrin alpha 6 messenger RNA overexpression in hepatocellular carcinoma*1, *2
Authors: N ARABEGUM
Journal: Hepatology (1995)

Our aim was to isolate potentially important differentially expressed gene products from paired human hepatocellular carcinoma (HCC) and normal liver samples using the differential messenger RNA (mRNA) display technique. Total RNA samples were reverse transcribed with anchoring oligonucleotide primers and then amplified by the polymerase chain reaction (PCR) with additional upstream random primers. Differentially expressed complementary DNA (cDNA) products were subsequently used as probes in Northern blot analysis. One such cDNA product, present in tumor but absent in normal displays, showed identity with the adhesion molecule integrin alpha 6. In Northern blots of 16 HCC pairs, the ∼5.5 kb signal of integrin alpha 6 mRNA was overexpressed in seven tumors, with a weak signal in the normal livers. For those patients with versus without integrin alpha 6 mRNA overexpression: (1) grade III (or IV) histology was noted in seven of seven versus three of nine tumors, respectively (P = .03); (2) tumor recurrence or death (at mean follow-up of 18 months) was noted in six of seven versus three of eight patients, respectively (P = .17). Similar results were obtained using semiquantitative PCR co-amplification with glyceraldehyde 3-phosphate dehydrogenase as a control; ∼50% of the tumors had stronger integrin alpha 6 bands than their paired normals. Both A and B variants of integrin alpha 6 mRNA were detectable in the tumor and normal liver samples. The B variant was more pronounced than the A variant by 8.9-fold in the tumors (n = 10) compared with threefold in the normal livers (n = 10), suggesting that the overexpression of integrin alpha 6 may be more reflective of abnormalities of B variant levels than of A variant levels. Important genes whose expression correlates with significant patient variables may be isolated by differential display; based on this small series there is a trend for integrin alpha 6 mRNA to be overexpressed in high-grade HCC and to predict a tendency toward a poorer outcome.
Eflornithine treatment of Pneumocystis carinii pneumonia in AIDS
Authors: T. M. Gilman
Journal: JAMA (1986)

<h3>To the Editor.—</h3> We have treated<i>Pneumocystis carinii</i>pneumonia (PCP) with the investigational drug eflornithine (α-difluoromethylornithine) in ten patients with acquired immunodeficiency syndrome (AIDS). Eflornithine irreversibly inhibits ornithine decarboxylase and prevents the biosynthesis of putrescine and other polyamines neces
Inhalers are just as safe without chlorofluorocarbons
Journal: BMJ (1998)

No clustering of anophthalmia occurs in England, but prevalence is higher in rural areas On p 905 Dolk et al describe a study set up to answer public concern after media allegations that clusters of babies were born with anophthalmia and microphthalmia in England and a link with pesticide exposure postulated.The results suggest little localised geographical clustering in babies born in 1988-94.However, the condition is more prevalent in rural areas and this observation requires confirmation and investigation.
When I use a word: Homogenous/homogeneous
Journal: BMJ (1999)

Objectives To investigate the effect of Chlamydia pneumoniae infection on future development of ischaemic heart disease and mortality.Design Prospective longitudinal study.Setting Caerphilly, South Wales.Subjects Plasma specimens were collected during 1979-83 from 1773 men aged 45-59 years.These were tested for IgG and IgA antibodies to C pneumoniae (TW183) by microimmunofluorescence. Outcome measures 13 year mortality and incident ischaemic heart disease events were ascertained from death certificates, hospital records, and electrocardiographic changes at follow up every 4 to 5 years.Results 642 men (36.2%) had IgG antibodies at a titre of >1 in 16, of whom 362 (20.4% of all men) also had detectable IgA antibodies.The prevalence of ischaemic heart disease (a history of past or current disease) at entry was similar at all IgG antibody titres but was positively related to IgA antibody titre.IgA antibody titre was positively correlated with plasma viscosity but not with other cardiovascular risk factors.Incidence of ischaemic heart disease was not associated with either IgG antibody titre or IgA antibody titre, but there were stronger and significant relations of IgA antibodies with all cause mortality and fatal ischaemic heart disease, which persisted after adjustment for conventional cardiovascular risk factors.The odds ratios associated with detectable IgA antibodies were 1.07 (95% confidence interval 0.75 to 1.53) for all incident ischaemic heart disease, 1.83 (1.17 to 2.85) for fatal ischaemic heart disease, and 1.50 (1.10 to 2.04) for all cause mortality.Conclusion This is the first prospective demonstration of an association between IgA antibodies to C pneumoniae, a putative marker of chronic infection, and subsequent risk of death from ischaemic heart disease.In contrast to earlier case-control studies, IgG antibodies were not associated with either prevalent or incident ischaemic heart disease.
Galactorrhea and hyperprolactinemia associated with amoxapine therapy. Report of a case
Authors: A. J. Gelenberg
Journal: JAMA (1979)

GALACTORRHEA and amenorrhea are adverse effects of<i>antipsychotic</i>drugs, attributed to elevated levels of serum prolactin, brought about by a blockade of dopamine (DA) receptors in the tuberoinfundibular hypothalamic pathway. Although galactorrhea is listed as an effect of tricyclic<i>antidepressant</i>drugs as well, a literature review has failed to substantiate this association. Moreover, the six currently available tricyclic antidepressants have<i>not</i>been found to increase serum prolactin levels,<sup>1</sup>nor do they appear to be effective blockers of the DA receptor. In the course of a double-blind study of a new antidepressant, amoxapine, galactorrhea developed in a young woman and was evaluated by extensive prolactin testing. This article describes her case, presents results of laboratory studies, and discusses theoretical and clinical implications. <h3>Report of a Case</h3> A 29-year-old woman had suffered from a primary depression, unipolar type, for about five months. One previous episode of depression had been treated with
Irradiation treatment of rheumatoid arthritis.
Journal: BMJ (1973)

The secondary hyperlipidaemias are common, and Alan (Chait discusses such causes of them as dialbetes mellitus, alcohol, chronic renal disease, hypothyroidism and gout.No lipoprotein pattern is epecific for any of these, and the pattern may vary from time to time in the same patient.Lars A. Carlson (Sweden) describes a classification with only three classes based on plasma cholesterol and tri- glyceride levels.He has used it in prospective studies of
Gynæcology for Nurses and Gynæcological Nursing Including the Subjects Enumerated Under Gynæcology and Obstetrics in the "Syllabus of Lectures and Demonstrations for Education and Training in General Nursing" Issued by the General Nursing Council for England and Wales.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TUBERCULOUS BACILLEMIA
Authors: J ANGEL de ARGUMOSA y VALDES
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Adverse effects of spinal manipulation: a systematic review
Authors: E Ernst
Journal: Journal of the Royal Society of Medicine (2007)

Main outcome measuresReports of adverse effects published between January 2001 and June 2006. There were no restrictions according to language of publication or research design of the reports. ResultsThe searches identified 32 case reports, four case series, two prospective series, three case-control studies and three surveys. In case reports or case series, more than 200 patients were suspected to have been seriously harmed. The most common serious adverse effects were due to vertebral artery dissections. The two prospective reports suggested that relatively mild adverse effects occur in 30% to 61 % of all patients. The case-control studies suggested a causal relationship between spinal manipulation and the adverse effect. The survey data indicated that even serious adverse effects are rarely reported in the medical literature. ConclusionsSpinal manipulation, particularly when performed on the upper spine, is frequently associated with mild to moderate adverse effects. It can also result in serious complications such as vertebral artery dissection followed by stroke. Currently, the incidence of such events is not known. In the interest of patient safety we should reconsider our policy towards the routine use of spinal manipulation.
SODIUM CITRATE TREATMENT OF THROMBO-ANGIITIS OBLITERANS
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Design Issues in Studies of Radon and Lung Cancer: Implications of the Joint Effect of Smoking and Radon
Authors: Mark Upfal, George Divine, Jack Siemiatycki
Journal: Environmental Health Perspectives (1995)

Many case-control studies have been undertaken to assess whether and to what extent residential radon exposure is a risk factor for lung cancer. Nearly all these studies have been conducted in populations including smokers and nonsmokers. In this paper, we show that, depending on the nature of the joint effect of radon and tobacco on lung cancer risk, it may be very difficult to detect a main effect due to radon in mixed smoking and nonsmoking populations. If the joint effect is closer to additive than multiplicative, the most cost-effective way to achieve adequate statistical power may be to conduct a study among never-smokers. Because the underlying joint effect is unknown, and because many studies have been carried out among mixed smoker and nonsmoker populations, it would be desirable to conduct some studies with adequate power among never-smokers only.
Acid Rain
Authors: Robert J. McCunney
Journal: JAMA (1985)

The brewery for Rolling Rock beer no longer uses water from the creek that bears its name, eating moose liver and kidney has been associated with cadmium intoxication, and the Taj Mahal is deteriorating. All these phenomena have been attributed to acid rain. Acid rain refers to precipitation altered by air pollution, in particular oxides of sulfur and nitrogen. Sulfur dioxide is released from power plants, electrical installations, and industrial sites such as foundries that use sulfur-based coals, whereas oxides of nitrogen are derived primarily from automobile exhaust. When the gases reach the atmosphere, a reaction takes place with moisture to form sulfuric and nitric acids, which increases the acidity of rain water. The effects of acid rain are peculiar because lakes and vegetation far from the generating source bear the greatest burden. Prevailing winds transport hazardous pollutants that are transformed into acids en route thousands of miles away. Acid
Announcement: Final 2015–16 Influenza Vaccination Coverage Estimates for Selected Local Areas, States, and the United States Available Online
Authors: Alycia Mcnutt, David Santoro, Christina Nishimura, Diane Noel, Katherine Kelley
Journal: MMWR Morbidity and Mortality Weekly Report (2016)

Final 2015-16 influenza season vaccination coverage estimates are available online at FluVaxView (http://www.cdc.gov/flu/fluvaxview/).The online information includes estimates of the cumulative percentage of persons vaccinated through the end of each month during July 2015-May 2016, for selected local areas, states, and regions as designated by the U.S. Department of Health and Human Services, and the
The Social and Economic Milieu of Health Care Provision: Quality, Access, and Cost
Journal: JAMA (1979)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Actinic reticuloid
Authors: Mary Ruth Buchness, Robin Ashinoff
Journal: Journal of the American Academy of Dermatology (1987)

acetonide.She became pregnant in June 1983.Four months later an explosive eruption of painful cysts, nodules, papules, and pustules, with intense erythema, developed on the central aspect of the face (Fig. 1).Bacterial cultures showed negative findings.Treatment initially included topical drying compounds, intralesional triamcinolone acetonide, and incision and drainage of cysts.The condition worsened.Erythromycin, 250 mg four times daily, and 1% hydrocortisone cream were ineffective.In November 1983, prednisone, 60 rag, was instituted.This resulted in a marked reduction in the swelling, erythema, and pain.From December 1983 through March 1984 prednisone, 30 mg daily, was given.Two weeks after delivery of a healthy full-term male infant in March 1984, isotretinoin, 40 mg twice daily, was begun.The dose of prednisone was decreased gradually and prednisone was discontinued in April 1984.During the first month of treatment with isotretinoin the facial eruption flared, with intensification of the erythema and an increase in drainage.At the completion of a 20-week course of isotretinoin, no new lesions were developing.She continued to improve over the next year, with gradual resolution of the erythema and improvement of the scarring (Fig. 2).On several occasions tetracycline was required to control eruptions.
Gastrointestinal Carcinoma and Concomitant Malignancy
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
<i>Announcement</i>: Amyotrophic Lateral Sclerosis (ALS) Awareness Month — May 2016
Journal: MMWR Morbidity and Mortality Weekly Report (2016)

May is Amyotrophic Lateral Sclerosis (ALS) Awareness Month. ALS, also known as Lou Gehrig's disease, is a progressive, fatal, neurodegenerative disorder of upper and lower motor neurons. The cause of ALS is not known, and no cure exists. Persons with ALS usually die within 2-5 years of diagnosis.
Theodor Billroth
Authors: Joshua Berrett
Journal: New England Journal of Medicine (1961)

THE attempted mastery of one profession, especially medicine, constitutes a lifetime task. One cannot help admiring physicians who have extended their specialized knowledge to produce significant accomplishment in other fields.One such example is Theodor Billroth, born on the island of Rugen in 1829. Pioneer of the surgery of the larynx and digestive tract, sensitive and melancholy beneath his calm exterior, a musician and poet, he was a self-styled "sentimental North Sea herring."Well aware as most physicians are of Billroth's medical contributions, few know that he not only was a musician but also wrote a book on the physiology . . .