tbuckley/cabot-search huggingface dataset:
Frequent Alcohol Consumption Among Women of Childbearing Age—Behavioral Risk Factor Surveillance System, 1991
Journal: JAMA (1994)

Alcohol use during pregnancy can cause fetal alcohol syndrome and other congenital anomalies. Substantial prenatal alcohol use can occur before a woman knows she is pregnant, and teratogenic risk increases if she continues to drink during pregnancy. Characterization of alcohol consumption patterns among women of childbearing age (i.e., age 18-44 years) can help identify the magnitude of this problem, the subpopulations at greatest risk, and the geographic areas in which increased prevention efforts are needed. This report presents state-specific data on the prevalence of frequent alcohol consumption among women of childbearing age.
Incorrect Wording
Authors: David Williams, Scott Brown, Daniel Clauw, R Gendreau
Journal: JAMA (2003)

levels (P = .16).Finally, patients' pain reports during their monthly visits to the clinic showed a slight but nonsignificant improvement from the late August visit to the late September visit (visual analog scale scores of 7.4 vs 6.1, respectively; P=.17).Comment.In this study using real-time assessment methods, a cohort of patients with chronic pain did not note any worsening of symptoms as an immediate consequence of the September 11 attacks, even though these individuals were living in the Washington, DC, area during this time period.This result is consistent with previous work suggesting minor daily problems rather than major events may drive somatic symptom expression. 6 Our conclusions are limited by our small sample size.Nonetheless, our data suggest that if there was truly an increase in health care use following September 11, this may have occurred independently of any actual change in symptomatology.For instance, seeking health care may be driven more by distress than by acute changes in symptoms. 7
Abstract 58: Magnetographic Recognition Of Abnormal Depolarization And Repolarization In Patients With Coronary Artery Lesions Caused By Kawasaki Disease
Authors: Wataru Tamaki
Journal: Circulation (2015)

Background: Noninvasive recognition of abnormalities of depolarization (DE) and repolarization (RE) in patients with coronary artery disease is difficult. Purpose: Our aim was to identify abnormalities of DE and RE in patients with coronary artery lesions (CAL) due to Kawasaki disease (KD) using magnetocardiography (MCG). Methods: We evaluated sixty one pts (48 males and 13 females) with CAL due to KD, The age at MCG ranged from 11 months to 38 years (median 15 years). Eleven pts had had previous myocardial infarction (MI), and 22 pts had had at least an occlusion of a major coronary artery branch. MCG was performed at rest with a multichannel superconducting quantum interference device system. The integral value was computed for each channel and isointegral maps were constructed during DE and RE. We analyzed abnormalities of DE and RE depending on occlusion of coronary arteries (OC) or a history of MI. Univariate analysis was performed on respective factors for DE and RE. Results: In the MI group, the number of abnormal DE and RE, abnormal DE and abnormal RE were 3 , 1 and 3, respectively. In OC group, the number of abnormalities of DE and RE was 2, and abnormality of RE was 9. In the non-OC group, the number of abnormal DE and RE was 2, and abnormal RE was 5. The factor of MI was significantly related on abnormal DE and abnormal RE (p&lt;0.05). On the other hand, the factor of OC was significantly related to abnormality of RE (p&lt;0.05). Conclusion: Although symptomatic coronary occlusion affects both DE and RE, occlusion of coronary artery only affects RE. MCG is useful to detect changes in DE and RE.
A NEW NEEDLE FOR COLLECTING BLOOD FOR SEROLOGIC TESTS
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A President in Shirtsleeves
Journal: Journal of the Royal Society of Medicine (2002)

The new President of the Royal Society of Medicine, Sir Barry Jackson, took office in mid-July 2002. A consultant surgeon at St Thomas’ Hospital for nearly thirty years, he is a longstanding Fellow of the Society—a member of the sections of Surgery, History of Medicine and Coloproctology (of which he became President) and serving on the Scientific and Executive Committee and the Council. Other presidencies have included the Association of Surgeons of Great Britain and Ireland and, most recently, the Royal College of Surgeons of England. He is an Honorary Consultant Surgeon to the Army and was formerly Surgeon to the Queen. He is interviewed here by Robin Fox.
BERLIN
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical characteristics and long-term survival of advanced breast cancer at the American University of Beirut Medical Center, Beirut, Lebanon
Authors: N. S. El-Saghir, M. Seoud, M. Charafeddine, J. Abbas, Z. Salem, F. Geara, K. Bikhazi, M. Khalifeh, M. Sidani, A. Shamseddine
Journal: Journal of Clinical Oncology (2004)

852 Background: Based on our earlier reports of increased incidence of breast cancer in younger aged-groups at presentation, we decided to review the clinical characteristics, treatment patterns and survival data of our patients (pts) with breast cancer. Patients and Methods: Retrospective review of the medical records of all pts with breast cancer treated at our institution from 1990 to 2001. Patient demographics, clinical characteristics, pathology, staging, and treatment of 1328 patients were reviewed. Follow-up data available on 810 patients was analyzed for survival. Results: Overall: Total number was 1328 pts. 43.9% were premenopausal, and 56.1% postmenopausal. Mean age at diagnosis was 50.81± 12 years. We had 322 patients with advanced stages as follows: 249 pts had locally advanced (stage III) and 73 pts had metastatic disease (stage IV) at presentation. Stage III: patients: Total number 249 pts (18% of total). 46.1% were premenopausal and (53.9%) postmenopausal. Mean age at diagnosis was 49.5±12. 10 pts (4.2%) had breast-conserving surgery and 217 pts (91.9%) had mastectomy. 53.7% had positive hormonal receptors (ER+/PR+: 35.2%, ER+/PR−13%, ER−/PR+ 5.6%) and 46.3% had negative receptors. 172 pts (73.8%) had neo-adjuvant and adjuvant chemotherapy. 86.6% are alive after 2 years of diagnosis, 66.7% after 5 years, and 47.8% after 10 years. Stage IV: Total number 73 pts (5.4% of total). 40.6% were premenopausal and 59.4% postmenopausal. Mean age at diagnosis was 52.8±13. 6 pts (8.2%) had mastectomy 54.2% had positive hormonal receptors (ER+/PR+: 37.5%, ER+/PR−: 16.7%, ER−/PR+: 0%) and 45.8% had negative receptors. 55 pts (79.7%) had chemotherapy. 51% of pts are alive at 2 years of diagnosis and 21% at 5 years. Conclusions: Only 26% of our patients with breast cancer have locally advanced disease and metastatic disease. We confirm the younger mean age at presentation. Multi-modality treatment gave very good survival in locally advanced stage III disease with 47.8% of pts alive at 10 years. Most stage IV patients had chemotherapy in addition to hormonal therapy 51% of stage IV pts survived 2 years and 21% 5 years. No significant financial relationships to disclose.
Abstract 1226: Augmentation Of Cardiac Function In Response To Pressure Overload In Transgenic Mice With A Cardiac-Specific Expression Of Adenylyl Cyclase Type 2
Authors: Che-Lin Hu, Shumin Gao, Chull Hong, Huasheng Liu, Yimin Tian, Heather Reinhardt, Yoshihiro Ishikawa, Stephen F Vatner, Dorothy E Vatner
Journal: Circulation (2007)

The results from studies examining the effects of transgenic (TG) mice with overexpression of the major adenylyl cyclase (AC) isoforms in the heart, AC5 and 6, has been controversial. Accordingly, we examined the effects of a non-calcium regulated AC isoform, AC2, by overexpressing it in the heart. This resulted in a 3 fold increase in overall cardiac AC activity. Baseline left ventricular ejection fraction (LVEF), measured by echocardiography, was higher (P&lt;0.05) in TG mice when compared to WT (75±1% vs 72±1%) while heart rate was similar (P&lt;0.05). The extent of increased LVEF stimulated by isoproterenol (ISO) was also higher in TG suggesting an increase in functional response of beta-AR signaling in these transgenic mice. Aortic banding for 1 wk induced significantly greater (P&lt;0.05) LV hypertrophy in TG compared to WT as indicated by LV weight (LVW)/tibial length (TL) ratio (7.1±0.4 vs 6.0±0.3 mg/mm, P&lt;0.05). Aortic banding resulted in no change of LVEF in the AC2TG (76±3%) or in WT (70±3%), i.e., LV function was maintained. Pathological examination of the 1wk banded hearts demonstrated fewer TUNEL positive myocytes in the AC2TG (0.16±0.08 cells/microm2) vs WT (1.00±0013 cell/microm2) (P&lt;0.05). Cross-sectional myocyte area in AC2TG was also larger (316±16microm2) than WT (289±20microm2) which confirmed the increased in LV/TL. Thus, a moderate level of AC2 overexpression in the heart increases the amount of cardiac hypertrophy, in response to pressure overload, but exerts a beneficial effect on apoptosis and LV function.
"Scare-Head" Journalism.
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Successful surgical treatment of atrial fibrillation. Review and clinical update
Authors: J. L. Cox
Journal: JAMA (1991)

Atrial fibrillation is the most common of all sustained cardiac arrhythmias, yet it has no effective medical or surgical therapy. During the past decade, multipoint computerized electrophysiological mapping systems were used to map both experimental and human atrial fibrillation. On the basis of these studies, a new surgical procedure was developed for atrial fibrillation. Between September 25, 1987, and July 1,1991, this procedure was applied in 22 patients with paroxysmal atrial flutter (n = 2), paroxysmal atrial fibrillation (n = 11), or chronic atrial fibrillation (n = 9) of 2 to 21 years' duration. All patients were refractory to all antiarrhythmic medications, and each patient failed to receive the desired therapeutic benefits of an average of five drugs administered preoperatively. There were no operative deaths and all perioperative morbidity resolved. All 22 patients have been successfully treated for atrial fibrillation with surgery alone. Three patients developed one late isolated episode of atrial flutter at 5, 6, and 15 months postoperatively, and each of these patient's symptoms is now controlled by a single antiarrhythmic drug. Preservation of atrial transport function has been documented in all patients postoperatively, and all have experienced marked clinical improvement. (<i>JAMA</i>. 1991;266:1976-1980)
Deafness associated with Lassa fever
Authors: L. P. Rybak
Journal: JAMA (1990)

Viral infections are now being recognized with increasing frequency to be causes of inner ear disorders, including deafness, vertigo, and facial palsy.<sup>1</sup>Sudden deafness has been associated with a significant rise in antibody titers directed against adenovirus, parainfluenza, and herpesviruses.<sup>2</sup>More recent serological surveys of patients who have idiopathic sudden hearing loss demonstrated seroconversions for antibodies against single or multiple viral agents. The most common viruses implicated were mumps, rubeola (measles), varicella-zoster, cytomegalovirus, and influenza B. It was interesting to note that the incidence of viral seroconversion and sudden hearing loss tracked each other closely, suggesting a relationship between viral infections and idiopathic sudden deafness. Sudden deafness was most prevalent in the spring in Boston during a 3-year study.<sup>3</sup>In England, serological studies of patients with sudden deafness revealed that mumps, measles, and herpes zoster were most commonly associated.<sup>4</sup>Histopathologic study of temporal bones removed during
TRAIL-R as a Negative Regulator of Innate Immune Cell Responses
Authors: Gretchen E. Diehl, Herman H. Yue, Kristina Hsieh, Anna A. Kuang, Mary Ho, Lisa A. Morici, Laurel L. Lenz, Dragana Cado, Lee W. Riley, Astar Winoto
Journal: Immunity (2004)
Editor’s Note
Journal: Psychotherapy and Psychosomatics (1996)

Starting in the New Year, our journal will experience some major improve ments for the benefit of the readers.After some consideration, the editor and the publishing house have decided to give the journal a new shape and larger size in order to visually upgrade it.This will also allow us to accommodate the material submitted for publication more comfortably and to facilitate handling.In addition, the mode of appearance will change from two volumes con taining four issues, to one volume containing six issues per year.Because of this innovation, the price for individuals will experience a considerable reduc tion off the subscription rate as compared with 1995.Finally, the readers will be pleased that we have initiated 'structured abstracts', providing them with quicker and more precise information.
Manic Illness
Authors: Hyman L. Muslin
Journal: JAMA (1980)

This is a worthwhile book for the general psychiatrist and perhaps for the physician in any specialty who has managed to keep himself knowledgeable in the recent findings in the physiology, biochemistry, and endocrinology of the brain, especially the hypothesis involving the catecholamine and indolamine theory of affective disorders. The chapters are well written and contain excellent critical reviews of the literature. I would recommend especially the chapters on the epidemiology and the pharmacology of mania. The tone of this volume is one of inquiry, and heavy-handed conclusions are avoided so that one can make a reasonable judgment on the state of current research and the need for more research. I would only add one caveat; the chapter on psychoanalytic aspects of mania is deficient in its coverage of the recent literature on this subject— conspicuously absent is the work of Jacobson and Kohut, two major contributors to psychoanalytic theory
Arthritis may follow jejunoileal surgery
Authors: J. Kangilaski
Journal: JAMA (1981)

Bacterial debris can find its way from the bowel to the bloodstream and ultimately into joints, where it may cause "bypass disease"—an arthritic complication affecting about 10% to 15% of the persons who have undergone jejunoileal surgery. (Reports, and an editorial, about other conditions associated with jejunoileal bypass are found on pages 970, 982, and 988.) Evidence for this comes from a study of the movement of radiolabeled bacterial cell wall fragments. A report on the study was presented at the Boston meeting of the American Rheumatism Association by Peter D. Utsinger, MD, director of the immunology laboratory at Germantown Medical Center, Philadelphia, and associate professor of medicine at Temple University School of Medicine. Utsinger believes that the study adds support to the view that "rheumatoid arthritis is potentially a disease that follows bacterial insult." This has a number of implications for clinical practice; for example, physicians may wish to
Improvements in Health-Related Quality of Life and Symptoms in Patients with Previously Untreated Chronic Lymphocytic Leukemia: Results from the Phase II GIBB Study of the Combination of Obinutuzumab and Bendamustine
Authors: Jeffrey P. Sharman, Habte Yimer, Michael Boxer, Nicholas Di Bella, Sunil Babu, Jia Li, Yong Mun, Peter Trask, Anthony Masaquel, Carolina M Reyes, Alexey Danilov
Journal: Blood (2017)
Halothane hepatitis.
Authors: T H Burns, M E Dodson, M W Johnstone
Journal: BMJ (1971)

compensated neurotic taking a small dose of amphetamine to a highly distressed human being making excessive demands on an already busy Eervice.In my view there is a strong case to be made for excluding patients who have been on amphetamines for several years from the current witch hunt, although I agree that no neurotics should be started on the drug at this point in time.-I am, etc.,
Book Review Orthopedic Surgery . By Sir Robert Jones, Bart., K.B.E., C.B., Ch.M., F.R.C.S. (England, Ireland, Edinburgh), F.A.C.S. (U. S. A.), and Robert Lovett, M.D., F.A.C.S. Second Edition Revised with Collaboration of Nathaniel Allison, M.D., F.A.C.S., Frank Ober, M.D., and Harry Platt, M.D., M.S., F.R.C.S. (England). New York, William Wood and Co. 1929. Price $11.00.
Journal: New England Journal of Medicine (1929)
A Symposium on Contributions of Comparative Physiology to General Physiology
Journal: JNCI Journal of the National Cancer Institute (1953)

A Symposium on Contributions of Comparative Physiology to General Physiology Get access JNCI: Journal of the National Cancer Institute, Volume 13, Issue 5, April 1953, Pages 1383–1385, https://doi.org/10.1093/jnci/13.5.1383 Published: 01 April 1953
Abstract 12660: Impact of Aortic Valve Replacement versus Medical Management on Survival of Low Flow Low Gradient Severe Aortic Stenosis With Normal Ejection Fraction
Authors: Zaher Fanari, Dimitrios Barmpouletos, Vivek K Reddy, Sumaya Hammami, Zugui Zhang, William S Weintraub, Erik S Marshall
Journal: Circulation (2015)

Background: The impact of aortic valve replacement (AVR) versus medical management (MM) in patients with paradoxical low flow is unclear. The objective of this study was to compare outcomes of AVR versus MM in patients with severe aortic stenosis and normal ejection fraction and different transaortic flow and gradient. Methods: We identified consecutive patients presenting to our echo lab with an aortic valve area (AVA) &lt; 1.0cm 2 and EF≥ 50%. We stratify patients depending on gradient (≥ 40 vs. &lt; 40 mmHg) and stroke volume index (SVI &lt; 35 vs. ≥35 ml/m 2 ). 4 groups were identified (, normal flow, high gradient [NF/HG]; normal flow, low gradient [NF/LG]; low flow, high gradient [LF/HG] and low flow, low gradient [LF/LG]. These 4 groups were also stratified depending on management (AVR vs. MM). All patients were retrospectively followed for the occurrence of death. Results: A total of 954 patients were included in analysis. Mean follow up was 2.45 ± 1.9 years. The mean age was 75.4 ± 5.6 years. Comparing all 4 AS subgroups, the mortality was higher in LF/HG followed by LF/LG, NF/HG and NF/LG (LF/HG 37.1% vs. LF/LG 33.9% vs. NF/HG 30.3%vs. NF/LG 20.2%; Log Rank Test, P=0.003). Patients who underwent medical therapy have a higher mortality than the overall cohort in all subgroups (LF/HG 44.3% vs. NF/HG 36.6% vs. LF/LG 33.7% vs. NF/LG 21.2%; Log Rank Test, P=0.001). Patients with HG had a higher chance of getting aortic valve replacement (AVR) than those with LF/LG and NF/LG (20.7% NF/HG vs. 10.6% LF/HG vs. 4.7% LF/LG and 3.6% NF/LG; P=0.01). Patients who underwent AVR had lower mortality rates when compared with the overall cohort in all subgroups (LF/HG 21.4% vs. 18.9% NF/HG vs. 6.6% LF/LG and 7.1% NF/LG; Log Rank Test, P= 0.253). Conclusion: Patients with LF/LG represent an under-recognized high-risk group with similar prognosis to NF/HG. Although these patients may benefit tremendously from AVR, they are less likely to undergo AVR when compared to HG patients.
National Black HIV/AIDS Awareness Day — February 7, 2020
Journal: MMWR Morbidity and Mortality Weekly Report (2020)

National Black HIV/AIDS Awareness Day (NBHAAD) is observed each year on February 7 to highlight the continuing disproportionate impact of human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS) on the U.S. black or African American (black) population.During 2018, blacks represented 13% of the U.S. population but accounted for 43% of all newly diagnosed HIV infections (1).In February 2019, a new national initiative, Ending the HIV Epidemic: A Plan for America (EHE), was proposed.The plan calls for intensified efforts to diagnose, treat, prevent, and respond to HIV infections in the United States, with an overall goal of reducing new HIV infections by ≥90% by 2030 (2).A study reported in this MMWR issue presents data on CDC-funded HIV testing and outcomes among blacks who were tested in jurisdictions that are the initial focus of EHE.In these jurisdictions during 2017, blacks accounted for 43.2% of CDC-funded tests and 49.1% of newly diagnosed HIV infections (3).CDC supports a range of efforts for reducing the risk for acquiring or transmitting HIV infection among blacks.Additional information is available at https://www.cdc.gov/hiv/group/racialethnic/africanamericans.