tbuckley/cabot-search huggingface dataset:
Intraphagolysosomal pH in Canine and Rat Alveolar Macrophages: Flow Cytometric Measurements
Authors: Peter Heilmann, Wolfgang Beisker, Ursula Miaskowski, Per Camner, Wolfgang G. Kreyling
Journal: Environmental Health Perspectives (1992)

Intracellular dissolution of inhaled inorganic particles is an important clearance mechanism of the lung and occurs in phagolysosomal vacuoles of phagocytes. Flow cytometric measurements of intraphagolysosomal pH in alveolar macrophages (AM) obtained from beagle dogs, Wistar rats, and from a baboon were made using fluorescein isothiocyanate-labeled amorphous silica particles (FSP). AM were obtained by bronchoalveolar lavage. FSP were phagocytized by AM in cell suspensions incubated in full media for 24 hr up to 6 days. Dual laser flow cytometry was performed and six-parameter list mode data were recorded from forward scatter, side scatter, and fluorescence intensities at 530 nm excited at 457 nm and 488 nm as well as logarithmic fluorescence intensity at wavelengths 630 nm excited at 488 nm. In this way it was possible to discriminate viable AM with phagocytized FSP from lysing AM with phagocytized FSP and from cells without FSP and from free FSP. Viable cells were distinguished from lysing cells by staining with propidium iodide immediately before the flow cytometric measurement. A calibration curve for the pH value was determined from FSP suspended in buffered media at pH values ranging from 3.5 to 7.5. First flow cytometrical results indicated that after an incubation time of 24 hr, the mean intraphagolysosomal pH of viable AM was 4.7 +/- 0.3 for dogs and 5.1 +/- 0.5 for rats. The intraphagolysosomal pH of the baboon AM was 4.5.
Calcium channel blockers and myocardial infarction. A hypothesis formulated but not yet tested
Authors: J. E. Buring
Journal: JAMA (1995)

In this week's<i>JAMA</i>, Psaty and colleagues<sup>1</sup>present findings from a case-control study that raise the possibility, but cannot evaluate definitively, whether calcium channel blockers prescribed for patients with hypertension increase risk of myocardial infarction. This retrospective study among enrollees of the Group Health Cooperative of Puget Sound compared those who had suffered a myocardial infarction (cases) with those who had not (controls), with respect to their prior use of various antihypertensive drug therapies. The authors reported that risk of myocardial infarction increased about 60% (risk ratio=1.6; 95% confidence interval [CI], 1.1 to 2.3) among hypertensive patients treated with a calcium channel blocker compared with those treated with diuretics alone, and this apparent adverse effect was even greater among those treated with high doses. See also p 620. Unfortunately, media reporting of the presentation of these findings at a recent scientific meeting triggered concern among users of these and
Author's reply
Authors: H. Bird
Journal: Annals of the Rheumatic Diseases (1992)

cance rating of one.The combinations of NSAIDs with a fi blocker, quinidine with cimetidine, and glibenclamide with a thiazide diuretic each occurred in one patient.These combinations have a significance rating of two.The combinations of NSAIDs with methotrexate, salicylates with enalapril, and digoxin with hydroxychloroquine each occurred in two patients.These combinations have a significance rating of four.None of the patients had reported a drug interaction before admission.The mean duration of admission was 39 days (range 7-84), during which time the only adverse reactions were diarrhoea secondary to auranofin in one patient and a skin rash secondary to sodium aurothiomalate in one patient.This small study supports previous studies illustrating the potential for drug interactions in patients with arthritis and emphasises the need for continued vigilance.Most potential drug interactions involve NSAIDs.'The absence of significant clinical drug interactions might be attributed to the judicious use of NSAIDs.They were reserved for the management of definite inflammation, and of the 33 patients receiving NSAIDs, 22 were receiving half the maximum recom- mended dose.
Renal dysfunction after arteriography
Authors: R. A. Mason
Journal: JAMA (1985)

Acute renal failure has been observed in patients undergoing angiography in which a hypertonic triiodinated contrast medium is used. To ascertain the incidence of renal dysfunction and the clinical risk factors, we did a prospective study in which creatinine clearance was measured before and immediately after 120 arteriographic procedures. Thirty-seven patients (31%) sustained a significant reduction in creatinine clearance after arteriography. No specific risk factor could be determined. Our findings, however, indicate that patients with preexisting renal insufficiency or diabetes mellitus are not at a higher risk for sustaining a fall in creatinine clearance after angiography. (<i>JAMA</i>1985;253:1001-1004)
Graves thyrotoxicosis following primary thyroid failure
Authors: W. J. Bremner
Journal: JAMA (1976)

THE DEVELOPMENT of primary nongoitrous hypothyroidism is usually associated with idiopathic atrophy of the thyroid or chronic thyroiditis.<sup>1</sup>In both of these conditions, normal thyroid tissue is largely or completely replaced by fibrous tissue and lymphocytic and plasma cell infiltrates. It is characteristic of these conditions that serum levels of endogenous thyroid-stimulating hormone (TSH) are elevated<sup>2</sup>and that administration of exogenous TSH does not cause a normal response in terms of thyroid hormone production or iodine uptake.<sup>3</sup>The clinical course is not characterized by improvement of the thyroid disease, and lifelong thyroid replacement therapy is usually required.<sup>4</sup> Recently, we have cared for a patient who, two years after the diagnosis of primary nongoitrous hypothyroidism confirmed by lack of responsiveness to TSH stimulation, manifested hyperthyroidism with a diffuse goiter. This unique sequence implies that (1) the development of primary nongoitrous hypothyroidism may not necessarily require lifelong thyroid
EXCISION OF CANCER OF THE HEAD AND NECK.WITH SPECIAL REFERENCE TO THE PLAN OF DISSECTION BASED ON ONE HUNDRED AND THIRTY-TWO OPERATIONS.
Authors: GEORGE CRILE
Journal: JAMA (1906)

Though signal advances have been made recently in many surgical problems, the treatment of cancer of the head and neck has, it would seem, neither received the attention nor kept the pace of progress in other fields. These unhappy cases are too often regarded as specters at the clinic. The operative treatment is hampered by tradition and conventionality, and the tragic ending of so large a proportion of these cases has held back lay and even professional confidence. In this paper it is intended to present an outline sketch of the conclusions regarding the surgical treatment of cancer of the head and neck in the curable stage. The etiology, the diagnosis and the pathology will not be considered. It is generally admitted that cancer is primarily a local disease. Each case, then, is presumably at some period curable by complete excision. The immediate extension from the primary focus is principally
Editorial: Premature ageing syndromes.
Journal: BMJ (1974)

movement, and further studies have claimed benefits from use of trypsin in sports injuries.The sportsman with a soft-tissue injury must be guided on a path between two extremes.On the one hand the injury can be completely and safely immobilized and the risk ofincreasing the damage eliminated at the price ofslow recovery and residual stiffness.On the other hand vigorous active steps can be taken to achieve the most rapid possible recovery of function.Active exercises, massage, and heat will be given, and perhaps an anti-inflammatory drug or an oral enzyme added.Theoretically the last choice carries a risk of increasing the injury.The evidence ofcontrolled studies is that drug therapy confers some benefit, but that this is least when physiotherapy is active, early, and efficient.
First Aid in Emergencies
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Section 5: Prevalence of Rheumatic Disease
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Error in Results
Journal: JAMA Network Open (2019)

Bin Zhang, PhD; Min Min Li, MD; Wen Hui Chen, PhD; Jian Fu Zhao, PhD; Wei Qi Chen, PhD; Yu Hao Dong, MD; Xiao Gong, PhD; Qiu Ying Chen, MD; Lu Zhang, MD; Xiao Kai Mo, MD; Xiao Ning Luo, PhD; Jie Tian, MD, PhD; Shui Xing Zhang, MD, PhD
TRUTH AND FALSEHOOD IN MEDICINE.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE MEDICAL CARE OF THE SEAFARING CLASS.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MedGuide: at last a long-sought opportunity for patient education about prescription drugs
Authors: C. Marwick
Journal: JAMA (1997)

PROVIDING patients with adequate information concerning the drugs their physicians prescribe has long been the expressed goal of health care professionals from physicians to pharmacists. But it has proved an elusive one. Now, however, the aim has moved measurably closer to achievement. It has been estimated that 30% to 50% of patients do not follow prescribed drug regimens because of lack of information. The result is therapeutic failure and adverse drug events, said Peter H. Rheinstein, MD, director of medicine at the Food and Drug Administration (FDA). He said that among outpatients in the United States, drug-related morbidity and mortality is estimated to cost $76.6 billion annually. Estimates such as this have provided the driving force for moves to provide adequate information to patients about prescription drugs. But for almost 2 decades, none of the groups involved seemed to agree on how, by whom, or in what form this information
Ultrasonic evaluation of pulsatile abdominal masses
Authors: T. H. Shawker
Journal: JAMA (1978)

Gray scale ultrasound B-mode scanning provides a rapid and safe method for evaluating the origin of a pulsatile midline abdominal mass. In those patients who do not have an aortic aneurysm, ultrasound will frequently provide another explanation. Tortuous aortas, pancreatic pseudocysts, metastatic cancers, lymphomas, and low-lying livers may all present as pulsatile masses clinically mimicking an aortic aneurysm. Visualization of the para-aortic soft tissues as well as the aorta allows these conditions to be distinguished by abdominal ultrasound. (<i>JAMA</i>239:419-422, 1978)
Estimates of physician requirements for 1990 for the specialties of neurology, anesthesiology, nuclear medicine, pathology, physical medicine and rehabilitation, and radiology. A further application of the GMENAC methodology
Authors: M. A. Bowman
Journal: JAMA (1983)

The Graduate Medical Education National Advisory Committee (GMENAC) adjusted needs-based model for determining physician requirements was applied to the specialties of anesthesiology, neurology, nuclear medicine, pathology, physical medicine and rehabilitation, and radiology, which had not been completed at the time of the original GMENAC final report. Physical medicine and rehabilitation continues to be projected as a shortage specialty; anesthesiology is in near balance. Neurology and pathology are no longer projected to be specialties of oversupply, but rather to be in near balance. Diagnostic radiology continues to be projected as a specialty of oversupply; therapeutic radiology is projected to be in near balance, as is nuclear medicine. The GMENAC aggregate-requirements estimates are thus revised upward from 466,000 to 473,000 full-time equivalent physicians for 1990, reducing the projected surplus from 15.0% to 13.3%. (<i>JAMA</i>1983;250:2623-2627)
Ethics
Authors: Edmund D. Pellegrino
Journal: JAMA (1993)

The right of patients and their surrogates to participate in medical decisions is now firmly established in law and ethics. What is currently being debated is how far this right of participation extends. The controversy arises from several recent court cases in which surrogates have demanded treatments physicians have judged medically futile. As a result, several new questions are at issue: Are there limits to the patient's right of participation? Are there conditions under which physicians may be ethically obliged to refuse to provide, or even to offer, specific treatments? Who defines treatment futility and by what criteria? The right of participation was first asserted as a patient's right to refuse even life-sustaining treatments.<sup>1,2</sup>Fifteen years ago in the<i>Quinlan</i>case,<sup>3</sup>this was extended to include the right of surrogates of incompetent patients to refuse life-support measures even if a physician judged them medically and ethically appropriate. This
Memoir on Turning, as an Alternative for Craniotomy and the Long Forceps, in Deformity of the Brim of the Pelvis, &amp;c. &amp;c
Authors: J. Y. Simpson
Journal: BMJ (1848)

Measrements of theBiparietaland Bimastoid Disame- ters qf the heads of aix Infants at Birth.Number Biparietal Bimstoid Difference fu iaebes Biamastoid between the Case.iaees Dimtr.two.In. Sths.In. 8ths.In.
Early and late clinical outcomes after successful coronary revascularization in patients with moderately and severely reduced renal function Masashi Iwabuchi, Hideyuki Nosaka, Takeshi Kimura, Naoya Hamasaki, Hiroyoshi Yokoi, Masakiyo Nobuyoshi. Kokura Memorial Hospital, Kitakyushu, Japan
Journal: Journal of the American College of Cardiology (2001)
Multiple Disorders in the Elderly
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Combined endobronchial and esophageal endosonography for the diagnosis and staging of lung cancer: European Society of Gastrointestinal Endoscopy (ESGE) Guideline, in cooperation with the European Respiratory Society (ERS) and the European Society of Thoracic Surgeons (ESTS)
Authors: Peter Vilmann, Paul Clementsen, Sara Colella, Mette Siemsen, Paul De Leyn, Jean-Marc Dumonceau, Felix Herth, Alberto Larghi, Enrique Vazquez-Sequeiros, Cesare Hassan, Laurence Crombag, Daniël Korevaar, Lars Konge, Jouke Annema
Journal: Endoscopy (2015)

Correction to: Combined endobronchial and esophageal endosonography for the diagnosis and staging of lung cancer: European Society of Gastrointestinal Endoscopy (ESGE) Guideline, in cooperation with the European Respiratory Society (ERS) and the European Society of Thoracic Surgeons (ESTS)Endoscopy 2015; 47(06): 545-559DOI: 10.1055/s-0034-1392040
OF PERENNIAL INTEREST.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal