tbuckley/cabot-search huggingface dataset:
Resident Redux
Authors: Abraham Verghese
Journal: Annals of Internal Medicine (2004)

Perspectives15 June 2004Resident ReduxAbraham Verghese, MD, MFA, DSc (Hon)Abraham Verghese, MD, MFA, DSc (Hon)From the Center for Medical Humanities and Ethics, University of Texas Health Sciences Center, San Antonio, Texas.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-140-12-200406150-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Shortly after reading the poignant essay published in this issue (1), I was invited to give grand rounds at a leading medical school. Later, I sat in on a residents' journal club in a cozy room in a brick building that was part of the original hospital. We were packed around a table laden with sandwiches and soda. Latecomers either stood or sat crosslegged on the floor. The paper being discussed dealt with whether there was a benefit to a "drug holiday" during antiretroviral therapy.Suddenly, I experienced an acute sense of dislocation: It was as if a time warp ...References1. Srivastava R. A foreign concept. Ann Intern Med. 2004;140:1057-8. LinkGoogle Scholar2. Berk SL. A piece of my mind. International medical graduates in the United States. An interview with Sir William Osler. JAMA. 1991;266:1760-1. [PMID: 1890708] CrossrefMedlineGoogle Scholar3. Ludmerer KM. Time to Heal. New York: Oxford Univ Pr; 1999. Google Scholar4. Bloom A. From Socrates' Apology to Heidegger's Rektoratsrede.. In: Bloom A, eds. The Closing of the American Mind. New York: Simon and Schuster; 1987:253. Google Scholar5. Osler W. Aequanimitas With Other Addresses to Medical Students, Nurses, and Practitioners of Medicine. 3rd ed. Philadelphia: Blakistone's Son; 1932. Google Scholar Author, Article, and Disclosure InformationAuthors: Abraham Verghese, MD, MFA, DSc (Hon)Affiliations: From the Center for Medical Humanities and Ethics, University of Texas Health Sciences Center, San Antonio, Texas.Disclosures: None disclosed.Corresponding Author: Abraham Verghese, MD, MFA, DSc (Hon), 7703 Floyd Curl Drive, Mail Code 7730, San Antonio, TX 78229-3900. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoA Foreign Concept Ranjana Srivastava Foreign Medicine Mohsen Eledrisi Metrics Cited byHealthcare Providers' Responses to Narrative Communication About Racial Healthcare DisparitiesWhat Causes Racial Health Care Disparities? A Mixed-Methods Study Reveals Variability in How Health Care Providers Perceive Causal AttributionsForeign MedicineMohsen Eledrisi, MD 15 June 2004Volume 140, Issue 12Page: 1034-1036KeywordsBirthChildrenEmotionsFellowshipsGraduate medical educationJewish peopleRacial and ethnic issuesResidencyRiversSchizophrenia ePublished: 15 June 2004 Issue Published: 15 June 2004 Copyright & PermissionsCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Ulcer wars
Authors: M. Mosley
Journal: BMJ (1994)

been commonly reported except for incidents in the 1980s related to soya bean dust in Barcelona, Spain'; castor bean dust in Toledo, Ohio, United States, in the 1920s4; and sulphuric acid mists in Yokkaichi, Japan, in the 1960s.5This epidemic placed great pressure on the emergency services.We are forming a research group to undertake a detailed study of the epidemic.Better understanding may allow such episodes to be predicted so that advice can be provided to people with asthma and to health care providers.
Computer-aided diagnostic screening for 100 common diseases
Authors: K. Brodman
Journal: JAMA (1966)

The heavy load of his professional duties often leaves the practicing physician little time to question each patient fully about symptoms other than those associated with the present illness. Consequently, unless the patient himself brings additional symptoms to the attention of the physician, diseases, some of grave importance, may be overlooked. This communication describes the results of a study of the effectiveness of a multiple-screening method devised to identify patients who have complexes of symptoms significant for 100 diseases frequently encountered in medical practice. The objectives of the method are to screen patients for these diseases effectively, rapidly, and without strain on the physician's time or facilities. The method, called the Medical Data Screen (MDS), is in essence a laboratory-type procedure, in which a questionnaire is used to collect comprehensive histories and a computer is used to categorize and analyze items of history for each of the 100 diseases. The
A Philippine Evil.
Authors: None A. L. G.
Journal: JAMA (1899)

Paris, France, July 20, 1899. <h3>To the Editor.</h3> —The lay as well as the medical public already recognizes that the torrid heat and drenching rains of a tropical climate are more to be dreaded by the American pacificator, than its hostile and treacherous mongrel population, but the non-professional community does not understand that which even the medical fraternity at home is slow to declare—a far greater evil than even these menaces the youthful soldiers, and through them, when they return, the people of our own land with whom they come in contact. Among the harpies, whose nests are in the East Indies and countries bordering the China Sea, there is none more ravenous and destructive than the lues venerea, whose victims are first the young and vigorous males of the race, and through them, those whom they infect, these remotely to empoison others. No amount of religious instruction or moral
Wording Errors in Abstract, Numeric Errors in Results, and Labeling Errors in Figure 2
Authors: Kevin Wu, Thanh-Lan Bui, April Armstrong, Frank Netter
Journal: JAMA Dermatology (2019)

Pablo Vieyra-Garcia, PhD; Regina Fink-Puches, MD; Stefanie Porkert, MD; Roland Lang, PhD; Sophie Pöchlauer, MD; Gudrun Ratzinger, MD; Adrian Tanew, MD; Sylvia Selhofer, MD; Sator Paul-Gunther, MD; Angelika Hofer, MD; Alexandra Gruber-Wackernagel, MD; Franz Legat, MD; Vijaykumar Patra, MSc; Franz Quehenberger, PhD; Lorenzo Cerroni, MD; Rachael Clark, MD, PhD; Peter Wolf, MD
J Thoracic &amp;amp; Cardiovascular Surgery, St. Louis
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Influence of dietary calcium phosphate on the disposition of bilirubin in rats with unconjugated hyperbilirubinemia
Authors: C Van Der Veere
Journal: Hepatology (1996)

The aim of this study was to test a possible form of therapy that could be used in the management of unconjugated hyperbilirubinemia. We hypothesized that unconjugated bilirubin (UCB) can permeate the intestinal wall and can thus be secreted with the feces. We have previously observed that UCB binds to amorphous calcium phosphate in vitro. Orally ingested amorphous calcium phosphate may act as a trapping agent for bilirubin in the intestine, thereby preventing back- diffusion across the intestinal wall. In this study, we tested whether feeding calcium phosphate leads to enhanced excretion of unconjugated bilirubin in Gunn rats. When a purified control diet was substituted by a high calcium phosphate diet, a decrease in bilirubin levels of 30% to 50% in male Gunn rats and of 23% in female rats was observed. The fecal output of bilirubin was more than doubled in Gunn rats in the first 3 days after the normal diet had been replaced by the high calcium- phosphate diet. The biological half-life of 3H-labeled bilirubin in blood was 89.8 +/- 17.2 hours in rats fed the purified control diet and 50.9 +/- 1.4 hours in rats fed the high calcium phosphate diet (P = .004). After 30 weeks, plasma bilirubin levels were still significantly lower in Gunn rats fed a high calcium phosphate diet. No differences were found in plasma concentrations of calcium, magnesium, phosphate, urea, and creatinine in both Gunn rats and Wistar rats on control or high calcium phosphate diets. This therapy might be useful in the management of Crigler-Najjar patients, for example, as an adjunct to phototherapy.
How Much do Doctors know about Consent and Capacity?
Authors: Elizabeth Jackson, James Warner
Journal: Journal of the Royal Society of Medicine (2002)

To assess knowledge of capacity issues across different medical specialties we conducted a cross-sectional survey with a structured questionnaire at academic meetings, lectures and conferences. Of 190 individuals who received the questionnaire 129 (68%) responded-35 general practitioners, 31 psychiatrists, 29 old-age psychiatrists and 34 final year medical students. Correct answers on capacity to consent to or refuse medical treatment were given by 58% of the psychiatrists, 34% of the geriatricians, 20% of the general practitioners and 15% of the students. 15% of all respondents wrongly believed that a competent adult could lawfully be treated against his or her will, with no obvious differences by specialty. As judged by this survey, issues of capacity and consent deserve more attention in both undergraduate and postgraduate medical education.
Who should treat acute leukemia?
Authors: J. F. Holland
Journal: JAMA (1969)

Acute leukemia is a generic term representing a L variety of closely related diseases characterized by abnormal proportions of immature hematopoietic cells, often with abnormal morphological features. These diseases in their untreated state eventually prove lethal, nearly always within one year. Their cause or causes are unknown, and form the basis for a vast spectrum of fundamental research. The treatment of acute leukemia can be divided into approximately three historical stages: (1) before 1947, the era of despair with no effective treatment, (2) from 1947 to 1963, the advent of chemotherapy, and with the failure to find a curative drug, the era of palliation, and (3) since 1963, when induction therapies, complementary treatments including consolidation, intensification, maintenance, and inducer dosing, the multiple combinations of drugs, the appearance of new chemotherapeutic agents, and the beginnings of successful immunotherapy have made palliation alone too mean a goal. Chemotherapeutic cure is now a
Incorrect Sentences in Discussion
Authors: Guillaume Leurent
Journal: JAMA Internal Medicine (2016)

Justine E. F. Moonen, MD; Jessica C. Foster-Dingley, MSc; Wouter de Ruijter, MD, PhD; Jeroen van der Grond, PhD; Anne Suzanne Bertens, MD; Mark A. van Buchem, MD, PhD; Jacobijn Gussekloo, MD, PhD; Huub A. Middelkoop, PhD; Marieke J. H. Wermer, MD, PhD; Rudi G. J. Westendorp, MD, PhD; Anton J. M. de Craen, PhD; Roos C. van der Mast, MD, PhD
EXPERIMENTAL ALLERGIC GLOMERULONEPHRITIS INDUCED IN THE RABBIT WITH HOMOLOGOUS RENAL ANTIGENS
Authors: Emil R. Unanue, Frank J. Dixon, Joseph D. Feldman
Journal: The Journal of Experimental Medicine (1967)

Rabbits immunized to several homologous renal antigens developed a variety of autoantikidney antibodies. Some of these antibodies reacted with the host's glomeruli and appeared to cause glomerulonephritis. Passive transfer of sera from some of these nephritic rabbits into normal, unilaterally nephrectomized rabbits led to the induction of nephritis. The production of autoantibody to glomeruli was transitory in most instances in spite of continued immunization. In some rabbits immunized to whole kidney homogenate, extracts or sediment, antibodies were found fixed to renal tubular basement membranes where an ultrastructural lesion was demonstrated. Rabbits also produced antikidney antibody apparently to tubular cytoplasmic components which did not fix to kidney in vivo and were of no pathogenetic significance. Immunization with autologous renal basement membranes induced a small autoantibody response in half the rabbits. This response was not associated with detectable renal injury.
RIO DE JANEIRO
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Control of rabies.
Journal: BMJ (1969)

BJOURNA 185 lesions, which can be troublesome and very chronic,15 R. A.Cawson"' has recommended sucking pellets of betamethasone 17-valerate.Since many cases of both types of lichen planus are mild, corticosteroids should be reserved for patients suffer- ing appreciable symptoms that cannot be relieved by simple methods. Control of RabiesThe case of canine rabies reported in Britain last week must raise the question whether the quarantine imposed on imported dogs and cats is long enough.In fact the question might well be asked, Can any reasonable period of quarantine be certain to exclude rabies ?If it cannot, the import of animals capable of bringing the disease into the country should be altogether prohibited.This exceedingly dangerous disease is of virtually world- wide distribution.In recent years it has spread throughout the wild animals of Europe to a remarkable extent.Britain, like Australia, New Zealand, and some other islands, remains one
BOOK REVIEW
Authors: A. TURK
Journal: JNCI Journal of the National Cancer Institute (1988)

Journal Article BOOK REVIEW Get access Environmental Carcinogens: Methods of Analysis and Exposure Measurement. Volume 9. Passive Smoking. I. K. O'Neill, K. D. Brunnemann, B. Dodet, and D. Hoffmann, eds. Scientific Publication No. 81. Lyon, France: International Agency for Research on Cancer, 1987 372 pp. $80. AMOS TURK AMOS TURK The City College, The City University of New YorkNew York, NY 10031 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 80, Issue 10, 20 July 1988, Pages 776–777, https://doi.org/10.1093/jnci/80.10.776-a Published: 20 July 1988
Computer-stored medical records. Their future role in medical practice
Authors: C. J. McDonald
Journal: JAMA (1988)

Over the next few years, computer-stored medical records will become technically and economically feasible on a broad scale. Hybrid systems that include computer and traditional paper versions of the medical record and obtain their data from existing ancillary service systems will soon be widely available. Completely electronic medical records will follow. However, standards for exchanging clinical information between independent computers are needed to eliminate the reentry or interfacing costs otherwise required to obtain data from computerized ancillary services. Three kinds of benefits may be expected: (1) improved logistics and organization of the medical record to speed care and improve care givers' efficiency, (2) automatic computer review of the medical record to limit errors and control costs, and (3) systematic analysis of past clinical experience to guide future practices and policies. (<i>JAMA</i>1988;259:3433-3440)
Human Plague—United States, 1993-1994
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Introduction to the Management of Immunosuppression
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SYNOSTOSIS—AN INHERITED DEFECT
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 201: The mechanism of vascular mimicry in clear cell renal cell cancer
Authors: Jun-Ping Yang, Xing-Si Peng, Chao-Nan Qian
Journal: Cancer Research (2019)

Abstract Although anti-angiogenic drugs were used as first-line treatment in metastatic clear cell renal cell cancer (ccRCC), some patients with metastatic ccRCC still had limited survival benefit from anti-angiogenic therapy. The main reason was resistance to anti-angiogenesis treatment. Tumor blood vessel could be divided into endothelial cell-derived or tumor cell-derived vessels. Tumor cell-derived vascular channel was called as tumor vascular mimicry (VM). PAS-CD34 staining in ccRCC tissues revealed that the expression status of VM was different in ccRCC patients. And the progression-free survival and overall survival were significantly shorter in ccRCC patients with high VM expression level. To explore the effect of VM on the resistance to anti-angiogenesis treatment and the molecular mechanism of VM, we successfully established a three-dimensional culture model for the formation of tumor cell-derived vessel-like structures. We found the formation of blood vessel-like structures in kidney cancer cells was not affected by the anti-angiogenic drug, such as Sunitinib, suggesting that VM was closely associated with resistance to anti-angiogenic therapy. Moreover, we had discovered the “molecular signature of vascular mimicry in renal cancer”. Using this signature, 531 ccRCC patients in TCGA could be divided into two groups with different prognosis. More importantly, we found that HGF/c-MET signaling pathway regulated the expression of Serpinb2 through the downstream AKT pathway, and thus affected the formation of vascular mimicry in SN12C, 786-O cells. In addition, we also had found that HGF could promote the formation of blood vessel-like structure in lung and bladder cancer cells, and the " molecular signature of vascular mimicry in renal cancer " also could differentiate patients with renal papillary carcinoma, bladder cancer, endometrial cancer, lung adenocarcinoma cancer, and pancreatic cancer. These finding suggested that the molecular mechanism of vascular mimicry in renal cancer was universal, to some extent. This project partially elucidated the molecular mechanism of vascular mimicry in renal cancer and its clinical significance, laying a theoretical foundation for the development of more effective anti-angiogenic drugs. Citation Format: Jun-Ping Yang, Xing-Si Peng, Chao-Nan Qian. The mechanism of vascular mimicry in clear cell renal cell cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 201.