tbuckley/cabot-search huggingface dataset:
Paroxysmal nocturnal hemoglobinuria: Analysis of the effects of mutant PIGA on gene expression
Authors: Nobuko Kanai, Theresa M. Vreeke, Charles J. Parker
Journal: American Journal of Hematology (1999)

Compelling evidence indicates that mutations in PIG-A are necessary for the development of paroxysmal nocturnal hemaglobinuria (PNH), however, it is unclear why mutant PIG-A stem cells have a selective advantage. Further, multiple, discrete PIG-A mutations have been detected in the peripheral blood and bone marrow of patients with PNH, but the contribution of the different mutant clones to hematopoiesis is variable. This observation implies that factors in addition to mutant PIG-A influence the proliferative properties of the abnormal cells. To investigate the etiology of the selective advantage and the clonal dominance in PNH, gene expression in cells with mutant PIG-A was analyzed. Representational difference analysis was used to compare the pattern of cDNA expression between a human lymphoblastoid cell line with mutant PIG-A and its wild-type counterpart. These experiments demonstrated that the pattern of gene expression was different between the two cells lines in that the PIG-A mutant cells failed to express antiquitin mRNA. Transfection of the mutant cells with normal PIG-A restored expression of glycosyl phosphatidylinositol anchored proteins but not antiquitin. These experiments demonstrate that differences in the pattern of gene expression can occur independent of the PIG-A mutation. Depending upon the functional properties of the involved genes, these differences could influence the proliferative properties of PIG-A mutant cells and contribute to the selective advantage and clonal dominance that characterize PNH. Am. J. Hematol. 61:221–231, 1999. © 1999 Wiley-Liss, Inc.
Response
Authors: C. M. MOINPOUR, P. FEIGL, B. METCH, K. A. HAYDEN, F. L. MEYSKENS, J. CROWLEY
Journal: JNCI Journal of the National Cancer Institute (1989)

Journal Article Response Get access CAROL MCMILLEN MOINPOUR, CAROL MCMILLEN MOINPOUR Southwest Oncology Group Statistical Center Fred Hutchinson Cancer Research Center1124 Columbia St. Seattle, WA 98104 Search for other works by this author on: Oxford Academic PubMed Google Scholar POLLY FEIGL, POLLY FEIGL Southwest Oncology Group Statistical Center Fred Hutchinson Cancer Research Center1124 Columbia St. Seattle, WA 98104 Search for other works by this author on: Oxford Academic PubMed Google Scholar BARBARA METCH, BARBARA METCH Southwest Oncology Group Statistical Center Fred Hutchinson Cancer Research Center1124 Columbia St. Seattle, WA 98104 Search for other works by this author on: Oxford Academic PubMed Google Scholar KATHERINE A. HAYDEN, KATHERINE A. HAYDEN Southwest Oncology Group Statistical Center Fred Hutchinson Cancer Research Center1124 Columbia St. Seattle, WA 98104 Search for other works by this author on: Oxford Academic PubMed Google Scholar FRANK L. MEYSKENS, JR., FRANK L. MEYSKENS, JR. Southwest Oncology Group Statistical Center Fred Hutchinson Cancer Research Center1124 Columbia St. Seattle, WA 98104 Search for other works by this author on: Oxford Academic PubMed Google Scholar JOHN CROWLEY JOHN CROWLEY Southwest Oncology Group Statistical Center Fred Hutchinson Cancer Research Center1124 Columbia St. Seattle, WA 98104 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 81, Issue 14, 19 July 1989, Pages 1106–1107, https://doi.org/10.1093/jnci/81.14.1106 Published: 19 July 1989
Subcutaneous Nodules on the Fingers—Diagnosis
Journal: JAMA Dermatology (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Woman's Auxiliary to the American Medical Association
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ocular Pathology
Authors: Jay I. Perlman
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ireland
Authors: W Lyon, Edwin Dickson, Alexander Goodall, ; James's Ward, ; Gibson's Ward, Alexander Bruce', W Stuart, H Thomson, John Cotterill's Wards;, F Struthers, Mr Cathpart's Wards, Louis Fourie, T Fraser, Hugh Man3intyre, A M'callum, H Stewart, Andrew Smart, Norman Carmichael, Alex James, William Greer, John Cunningham, George Gibson, F Crosthwaite, Alex Bruce, George Mathewson, J Barbour, Archibald Oliver, W Roberthon, Andrewm Kendrick, Berry Hart, Geoffrey Cowan, Archibald Cotterill, Mr Cathcart, A Non-Resident, Wm Fraser, A M'intosh, Mr Thomson, Charles Neil, J Rousseau, E Elder, J Cruiekshank, J Dalmahoy, John Gibson, E Simmers, W Cotterill, A Cathcart, Wm Darling, James Galbraith, John Green, Hugh Jamieson, Arthur Brock, Murdoch Brownhmedical, John Bowie, Lovell Gulland, Braham Brown
Journal: BMJ (1905)

CEREBRO-SPINAL FEVER.TUE Local Government Board has issued a circular to the local sanitaryg authorities calling their attention to the fact tbkt cerebro-spinal fever has recently been somewhat exten- sively prevalent in Central Europe and in America.While the Board) considers that there is no ground for the apprehension that the disease has newly extended to or developed in Scotland, it yet advises local authorities to be on-the alert to detect tne presence of the disease in their dis- tricts, or, to satisfy themselves of its absence.The
A Book of Detachable Diet Lists for Albuminuria, Anemia and Debility, Constipation, Diabetes, Diarrhea, Dyspepsia, Fevers, Gout or Uric Acid Diathesis, Obesity, Tuberculosis and a Sick-room Dietary.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 4353: Stroma drive metabolic reprogramming and induces stemness properties in pancreatic cancer cells
Authors: Kousik K. Kesh, Vineet K. Gupta, Nikita Sharma, Roey Hadad, Vikas Dudeja, Ashok Saluja, Sulagna Banerjee
Journal: Cancer Research (2019)

Abstract Pancreatic Ductal Adenocarcinoma (PDAC) is one of the most devastating human malignancies with poor survival rate owing to chemoresistance and relapse. Small population of Tumor Initiating Cells (TIC) are considered major players driving these traits. Recent literature has demonstrated the importance of microenvironment “niche” in enrichment of these TIC populations. The desmoplastic stroma in pancreatic cancer comprising of stromal cells and immune cells are instrumental in pathogenesis and progression of PDAC. Among many cytokines, IL-6 a pro-inflammatory cytokine plays a major role in it. In this study, we show that stromal cell secreted IL6 altered metabolic reprogramming and increased cancer stemness in PDAC cells. PDAC cells cultured with pancreatic stellate cells condition media (PSC-CM) or recombinant IL6 and stem ness markers expression were investigated. Cytometry Bead Array (CBA) were used for cytokine profiling. Metabolic alteration along with TIC gene expression were measured using flow cytometry and Seahorse. PDAC cells when cultured with PSC-CM exhibited increase glucose uptake along with an enrichment of CD133+ population. An analysis of the conditioned media using CBA reveled that PSC-CM is enriched with cytokine IL-6 and TNF-α. Treatment of PDAC cells with recombinant IL-6 increased expression of self-renewal genes SOX2, OCT4, Nanog along with biochemical marker ALDH. In addition, TIC marker CD133 and invasion marker gene MMP7 expression also increased upon IL6 induction. Moreover, IL6 treatment increased glucose uptake and lactate secretion. Small molecule inhibitor Stattic (inhibitor of STAT3) inhibit glucose uptake and stemness gene expression.Our study shows that stromal IL6 altered metabolic reprogramming in cancer cells as well as increased cancer stemness and invasion. In future, the underlying mechanisms of IL-6 driven metabolic alteration and its impact on stemness and metastasis will be investigated. Citation Format: Kousik K. Kesh, Vineet K. Gupta, Nikita Sharma, Roey Hadad, Vikas Dudeja, Ashok Saluja, Sulagna Banerjee. Stroma drive metabolic reprogramming and induces stemness properties in pancreatic cancer cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4353.
PARIS LETTER.
Authors: None A. B.
Journal: JAMA (1884)

Paris, March14, 1884. A short time ago, Professor Germain Sèe read a very interesting paper at the Academy of Medicine on the diagnosis of pulmonary phthisis, in its various forms, which he has since published separately. It may be questioned as to whether there exist or not any cases of consumption without bacilli, or even without the classical tubercles; but the class of phthises without bacilli are, according to Professor Sée the only true phthises. The learned professor, true to his doctrine of the pathological unity of phthisis, declares that there is but one phthisis-phthisis tuberculosi, of which, it is true, the forms are varied. These are: 1. The so-called miliary granulation which is found in the lungs of phthisical patients, and often generalized in all the organs and in all the tissues. 2. The tubercle, properly so-called, grey or yellow, which follows the granulation. 3, The substance infiltrated
Queries and Minor Notes
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Debrisoquine Metabolic Phenotype and DNA-Based Assays: Implications of Misclassification for the Association of Lung Cancer and the Debrisoquine Metabolic Phenotype
Authors: N. E. Caporaso, P. G. Shields, M. T. Landi, G. L. Shaw, M. A. Tucker, R. Hoover, H. Sugimura, A. Weston, C. C. Harris
Journal: Environmental Health Perspectives (1992)

Debrisoquine is an antihypertensive drug that is metabolized by cytochrome P4502D6. Deficient metabolism is inherited as an autosomal recessive condition. We previously reported in a case-control study that extensive metabolizers of debrisoquine were at greater risk of lung cancer compared to poor and intermediate metabolizers. Cloning of the gene that encodes P4502D6 (CYP2D6) led to the identification of both wild-type and mutant forms of the gene. Subsequently, a DNA-restriction fragment length polymorphism (RFLP) was identified, and a Southern hybridization-based test was developed in an attempt to define the genotype. When the DNA-RFLP test was applied to stored DNA from our study subjects there was neither a significant association with the metabolic phenotype nor an association with lung cancer. Further work has demonstrated that the wild-type gene, which was characterized by a 29-kb allele, can also contain mutations that result in nonfunctional or absent proteins. When these mutations are present, individuals exhibit the poor or intermediate metabolizer phenotype in spite of the presence of the 29-kb putative wild-type allele. Sequence determination of the mutants led to the development of techniques to exploit the polymerase chain reaction, which, together with Southern analysis, have been reported to detect as many as 95% of poor metabolizers. This technique is being used to examine the association of the extensive metabolizer genotype with lung cancer in the subjects from the case-control study. Preliminary results indicate a weak association between the homozygous wild-type genotype and lung cancer; in contrast, the extensive metabolizer phenotype is strongly associated with lung cancer in this subset.(ABSTRACT TRUNCATED AT 250 WORDS)
Clinical Cardiology
Authors: David H. Spodick
Journal: JAMA (1972)

Both the principal strength and the potential weakness of single-authored texts is their systematic indoctrination with one man's wisdom. This frequently works well in relatively limited monographs, but is fraught with pitfalls in broader efforts. For cardiology, Friedberg's conspicuous success in maintaining uniform excellence while covering the entire field provides the stratospheric standard against which other single-authored texts continue to be judged. Schrire has covered the field, but without attempting to equal Friedberg's remarkable breadth and depth.<i>Clinical Cardiology</i>is intended as a less ambitious compendium, both quantitatively and qualitatively, which succeeds in discussing virtually every clinical facet of cardiology, but at the cost of displaying the particular pitfall of the one-man show—a certain amount of unevenness. Yet this book can be read and used profitably as a clearly written, succinct day-to-day clinical guide to analysis and action. Certain chapters are outstanding. Electrocardiographic contour abnormalities and vectorcardiography are admirably covered
Sulfur Metabolism: A Review of the Literature.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SPONGE-GRAFTING.
Authors: EDWARD C. BRIGGS
Journal: JAMA (1885)

13.)These strips are bent so as to throw the pads inward, and thus become springs to press the transverse processes of the dis¬ eased vertebrae forward, when the jacket is applied and laced up, thus producing the effects of the lever brace during the night.The forward pressure of the springs may be graduated and controlled by piercing the jacket on either side of the kyphos, and through these passing cords (s.s.Fig. 13) to the pads, so that they may be pulled back against the rear of the jacket, and there se¬ cured.This jacket, so modified, is an excellent spinal splint to be used during the day also, since it em¬ bodies the principles of the braces just described, and can be recommended for such cases as do not care to use a brace, and also for young children.In
Probilin.
Authors: Henry F. Page
Journal: JAMA (1907)

Philadelphia, Aug. 24, 1907. <h3>To the Editor:</h3> —The report on Probilin inThe Journal, August 24, explains my experience with the formula suggested by Dr. R. W. Wilcox in his article on "The Medical Treatment of Gallstone Disease" (The JournalA. M. A., Aug. 4, 1906, page 347). Being desirous of carrying out the treatment suggested by Dr. Wilcox, I prescribed the formula of phenolphthalein with acid sodium oleate and salicylic acid. The pharmacist to whom the prescription was submitted informed me that it could not be compounded as written, but that he could dispense the materials massed separately in a capsule. Subsequently the same pharmacist suggested the use of sodium salicylate in place of the salicylic acid, the following modified formula being prescribed: Sodium oleate.... 0.10 Sodium salicylate.... 0.10 Phenolphthaalein.... 0.05 Menthol.... 0.015 Mix and dispense in 1 capsule. The sodium oleate was prepared by mixing the proper pro
Regulation of IL-22 in a rat model for acute-on-chronic liver failure (ACLF)
Authors: Katharina Maria Schwarzkopf, Frank Uschner, Robert Schierwagen, Sabine Klein, Marcus Maximilian Muecke, Alexander Queck, Hans-Peter Erasmus, Christiana Graf, Martin Schulz, Stefan Zeuzem, Christoph Welsch, Vicente Arroyo, Joan Clària, Jonel Trebicka
Journal: Journal of Hepatology (2020)