tbuckley/cabot-search huggingface dataset:
The Power of a Symbol.
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CORONARY MICROVASCULAR DYSFUNCTION AND CLINICAL OUTCOMES IN PATIENTS WITH HEART FAILURE WITH PRESERVED EJECTION FRACTION
Authors: Tess Allan, Kathryn Dryer, Mark Gajjar, Jonathan Paul, Atman Shah, Sandeep Nathan, Javed Butler, Charles Davidson, William Fearon, Sanjiv Shah, John Blair
Journal: Journal of the American College of Cardiology (2019)
State-Specific Birth Rates for Teenagers—United States, 1990-1996
Journal: JAMA (1997)

During the late 1980s, birth rates for teenagers in the United States increased sharply. Although rates have declined steadily since 1991 (1,2), age-, race-, ethnicity-, and state-specific rates have varied substantially. Despite recent declines, the U.S. birth rate for teenagers remains high compared with other industrialized countries. In 1996, an estimated 505,514 females aged <20 years gave birth; two thirds of births to teenagers are unintended (3). The adverse consequences of teenage childbearing include increased poverty for both mother and child. This report presents state-specific birth rates for females aged 15-19 years for 1991 and 1995 and compares race/ethnicity-specific birth rates for U.S. females aged <20 years for 1990-1996. These findings indicate that, during 1991-1995, birth rates among teenagers declined significantly in all but five states and the District of Columbia, and declines nationwide during 1991-1996 were especially large for teenagers aged 15-17 years and for black teenagers. Recent declines in abortions and abortion rates forteenagers, coupled with the trends described in this report for birth rates for teenagers, indicate that, since 1991, pregnancy rates for teenagers also have declined.
Geriatric Surgery
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Art of Surgery: A Text-Book for Students and Practitioners
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
HAEMORRHAGIC COLITIS
Authors: J. P. Lockhart-Mummery
Journal: BMJ (1922)

<b>Background:</b> Downhill walking (DW) enhances quadriceps contractile muscle fatigue (CMF) with less symptoms than level walking (LW) in patients with COPD. Its use in clinical practice is limited by a lack of data regarding efficacy, acceptability and safety. <b>Aim:</b> To determine the feasibility, acceptability and safety of DW as part of pulmonary rehabilitation (PR) in patients with COPD. <b>Methods:</b> 39 COPD patients (62±9yrs; FEV<sub>1</sub> 49±17%pred) were randomised to PR with DW or LW. CMF was assessed via magnetic femoral nerve stimulation at week 2 &amp; 12. Feasibility was defined as protocol completion &gt;75% DW patients. Acceptability was assessed via surveys, and safety via incidence of adverse events and serum creatine kinase (CK) levels at weeks 0, 2, 6 &amp; 12. Training progression was analysed weekly. <b>Results:</b> The table shows development of CMF was maintained in DW more than LW. In DW, protocol completion rate was high (attrition unrelated to training) and adverse events rare (mild tendinopathy). CK levels were lower in DW compared to LW (p&lt;0.05 at week 6). Most patients 9agreed9 or 9strongly agreed9 that DW felt easy (12/17, 71%) and safe (15/17, 88%). DW was associated with improved walk speed, dyspnoea and leg fatigue than LW during weeks 6-12 (p&lt;0.05). <b>Conclusion:</b> DW as part of PR is feasible, acceptable, safe and enhances training progression more than LW. These data support the use of DW in exercise training programs for COPD.
Health outcomes following treatment for six months with once daily tiotropium compared with twice daily salmeterol in patients with COPD
Authors: V Brusasco
Journal: Thorax (2003)

Background: A study was undertaken to record exacerbations and health resource use in patients with COPD during 6 months of treatment with tiotropium, salmeterol, or matching placebos.Methods: Patients with COPD were enrolled in two 6-month randomised, placebo controlled, double blind, double dummy studies of tiotropium 18 µg once daily via HandiHaler or salmeterol 50 µg twice daily via a metered dose inhaler.The two trials were combined for analysis of heath outcomes consisting of exacerbations, health resource use, dyspnoea (assessed by the transitional dyspnoea index, TDI), health related quality of life (assessed by St George's Respiratory Questionnaire, SGRQ), and spirometry.Results: 1207 patients participated in the study (tiotropium 402, salmeterol 405, placebo 400).Compared with placebo, tiotropium but not salmeterol was associated with a significant delay in the time to onset of the first exacerbation.Fewer COPD exacerbations/patient year occurred in the tiotropium group (1.07) than in the placebo group (1.49, p<0.05); the salmeterol group (1.23 events/year) did not differ from placebo.The tiotropium group had 0.10 hospital admissions per patient year for COPD exacerbations compared with 0.17 for salmeterol and 0.15 for placebo (not statistically different).For all causes (respiratory and non-respiratory) tiotropium, but not salmeterol, was associated with fewer hospital admissions while both groups had fewer days in hospital than the placebo group.The number of days during which patients were unable to perform their usual daily activities was lowest in the tiotropium group (tiotropium 8.3 (0.8), salmeterol 11.1 (0.8), placebo 10.9 (0.8), p<0.05).SGRQ total score improved by 4.2 (0.7), 2.8 (0.7) and 1.5 (0.7) units during the 6 month trial for the tiotropium, salmeterol and placebo groups, respectively (p<0.01 tiotropium v placebo).Compared with placebo, TDI focal score improved in both the tiotropium group (1.1 (0.3) units, p<0.001) and the salmeterol group (0.7 (0.3) units, p<0.05).Evaluation of morning pre-dose FEV 1 , peak FEV 1 and mean FEV 1 (0-3 hours) showed that tiotropium was superior to salmeterol while both active drugs were more effective than placebo.Conclusions: Exacerbations of COPD and health resource usage were positively affected by daily treatment with tiotropium.With the exception of the number of hospital days associated with all causes, salmeterol twice daily resulted in no significant changes compared with placebo.Tiotropium also improved health related quality of life, dyspnoea, and lung function in patients with COPD.
PRACTICAL ANATOMY IN THE COLLEGES.
Journal: JAMA (1889)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Double-blind investigation of the effects of propranolol and placebo on the pressure of esophageal varices in patients with portal hypertension
Authors: F Feu
Journal: Hepatology (1991)

This study was aimed at investigating the effects of propranolol on esophageal variceal pressure in patients with portal hypertension. Variceal pressure was measured at endoscopy using a miniature pressure-sensitive gauge in 20 patients with portal hypertension. Measurements were obtained under baseline conditions and 20 min after double-blind administration of propranolol (0.15 mg/kg; n = 10) or an identical amount of placebo (normal saline, 0.3 ml/kg; n = 10). Under baseline conditions, variceal pressure was similar in propranolol and placebo groups (14.1 ± 5 mm Hg vs. 14.9 ± 6.6 mm Hg, respectively; not significant). Placebo had no significant effect on variceal pressure (baseline = 14.9 ± 6.6 mm Hg; placebo = 15.5 ± 6.6 mm Hg; not significant), and values after placebo administration were closely correlated with baseline values (r = 0.98; y = 1.1 + 0.97 x; p < 0.0001). In contrast, propranolol caused a significant decrease in the pressure of esophageal varices (from 14.1 ± 5 mm Hg to 11.3 ± 4.4 mm Hg; p < 0.002). No significant changes in the size of esophageal varices were observed after propranolol or placebo administration. This study shows (a) the endoscopic pressure-gauge technique has a low variability and may be used to assess acute drug-induced changes in variceal pressure; and (b) propranolol causes significant decreases in variceal pressure in patients with portal hypertension and esophageal varices. (HEPATOLOGY 1991;13:917–922.)
Methoxyflurane Toxicity
Authors: Edwin J. Goldman
Journal: JAMA (1970)

<h3>To the Editor.—</h3> In addition to "Toxicity Following Methoxyflurane Anesthesia" (<b>214</b>:86, 1970), several articles in the past months noted renal failure following methoxyflurane anesthesia.<sup>1,2</sup>All suffer from a common information gap. The anesthetic administration and management is dismissed in a few words eg, "under methoxyflurane anesthesia..." "The surgery lasted six hours, and there was no hypoxia or hypotension." While it is reassuring to note the absence of hypoxia and hypotension, your anesthesiologist reader wishes to know a great deal more. What per cent of anesthetic was administered? Was it in a closed system, or a semiclosed system, or nonrebreathing? Was nitrous oxide used as well and in what concentration? What was the total flow of gas? Were muscle relaxants used or was the anesthetic pushed to deep levels to provide relaxation? How long was each setting used? The answers to these questions would allow us to guess at
The internist's library
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diagnostische und therapeutische Irrtümer und deren Verhütung. Innere Medizin.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
IN LINE OF DUTY.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hepatic amebic abscess. Unresponsiveness to combination of metronidazole and surgical drainage
Authors: A. E. Stillman
Journal: JAMA (1974)

FOUR recent reports have illustrated the failure of large doses of metronidazole to cure hepatic amebic abscesses.<sup>1-4</sup>Metronidazole is considered the drug of choice in the treatment of invasive amebiasis.<sup>5</sup>' In combination with abscess drainage, metronidazole thus far has been uniformly successful in the therapy of hepatic amebic abscess.<sup>4,6</sup>A patient with hepatic amebic abscess was recently studied at Tucson Medical Center; the abscess failed to respond to a simultaneous combination of metronidazole therapy and surgical drainage of the abscess. <h3>Report of a Case</h3> A 24-year-old Mexican woman was referred to Tucson Medical Center because of jaundice that developed at childbirth. Two weeks before admission, she experienced onset of pleuritic right flank pain that radiated to the right shoulder. Two days before admission, she became jaundiced, and one day before admission, she gave birth to a stillborn infant. She had not been ill previously except for mild
Clinica de la encefalitis epidémica: Epidemiologia en Sud-América y en la R. Argentina. Estados agudos y crónicos. El parkinsonismo post-encefalítico. Sistema y síndromes extrapiramidales. La "psiquiatría de la región mesocefálica." La demencia bradifrenica. Forma endócrina, respiratoria, disfásica, espasmódica. Pronóstico. Tratamiento.
Journal: JAMA (1929)
THU0073 A proposed mechanism for autonomic dysfunction in rheumatoid arthritis – reduced vagal activity related to high intrathecal IL-1β levels
Authors: R. Altawil, D. Kadetoff, M. Westman, M. Jensen-Urstad, M. Andersson, E. Kosek, J. Lampa
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Rheumatoid arthritis (RA) is known to be associated with autonomic dysfunction, with a decreased vagus tone. However, the mechanisms have not been completely elucidated. Nervus vagus function is regulated by action of muscarinic receptors in the CNS (Pavlov, PNAS, 2006), and earlier investigations have shown that the pro-inflammatory cytokine interleukin (IL)-1beta may cause dysfunction in cholinergic neurotransmission (Schliebs, Brain Res 2006). <h3>Objectives</h3> Here we investigated autonomic activity in RA and controls in relation to serum and cerebrospinal fluid (CSF, only RA) levels of IL-1β and IL-6. <h3>Methods</h3> 14 female patients with RA and 15 female age matched healthy controls (HC) were enrolled in this study. Median DAS28 score for RA patients was 3.6 (range 1.5 to 6.6). No patient/control had any neurological or heart disorder. Heart rate variability (HRV) was measured with Holter ECG over 24 hours using spectral analysis of Low frequency (LF) power (0.04 to 0.15 Hz), High frequency power (HF) (0.15 to 0.40 Hz) and the ratio of LF and HF (LF/HF). The measures were calculated from an entire 24 h ambulatory ECG recording. Lumbar puncture was performed in RA patients only and CSF was analyzed with high sensitivity ELISA for IL-1β and IL-6. Serum samples were analyzed with ELISA for IL-1β and <h3>Results</h3> There were significant differences between RA and HC in heart rate (74±6 vs 66±5 bpm; p&lt;0.001), LF (522±213 ms<sup>2</sup> vs 885±523 ms<sup>2</sup>; p&lt;0.02), HF (252±280 ms<sup>2</sup> vs 560±657 ms<sup>2</sup>; p&lt;0.005) and a tendency of difference in LF/HF (2.5±0.7 vs 1.9±1; <i>ns</i>). These data are consistent with reduced vagal function in RA patients. In RA, IL-1β levels in CSF were markedly higher than serum levels (8.35±12.59 vs 0.00±0.06 pg/ml; p&lt;0.005) indicating intrathecal production. In contrast, CSF IL-6 levels were lower in CSF than serum (2.59±1.43 pg/ml vs 6.25±4.21 pg/ml, p=0.01). CSF IL-1β, but not IL-6, correlated positively with HRV, as measured with LF/HF (r=0.64; p&lt;0.05). Serum IL-1β was not correlated to HRV, but serum IL-6 correlated inversely to LF both in RA (r=-0,55 p&lt;0.05) and controls (r=-0.46; p&lt;0.05). <h3>Conclusions</h3> The decreased autonomic function in RA, reflected in low vagus activity and thereby reduced control of systemic inflammation, may further impair the disease. Our data indicate that intrathecal IL-1beta and possibly also other inflammatory mechanisms in the CNS may have importance for the reduced vagal function of RA. These mechanisms may constitute future targets for improvement of cholinergic immune-suppression of the disease. <h3>Disclosure of Interest</h3> None Declared
Vascular dysfunction after repair of coarctation of the aorta
Authors: Marcello de Divitiis, Carlo Pilla, Mia Kattenhorn, Mariutzka Zadinello, Ann Donald, Paul Leeson, Sharon Wallace, Andrew Redington, John E. Deanfield
Journal: Circulation (2001)

Background Patients with repaired coarctation are at increased risk of hypertension and cardiovascular disease despite successful repair. We studied the function of conduit arteries in upper and lower limbs of patients late after successful coarctation repair and its relation to age at surgery. Methods and Results Flow-mediated dilatation (FMD) and the dilatation after sublingual nitroglycerin (NTG, 25 μg) were measured by using high-resolution ultrasound in the brachial artery in 64 coarctation patients (44 males and 20 females, aged 19±10 years; median age at operation 4 months) and 45 control subjects (28 males and 17 females, aged 19±10 years) and in the posterior tibial artery in 37 patients and 22 control subjects. Arterial stiffness was determined by pulse-wave velocity (PWV) of the brachioradial and femoral-dorsalis pedis tracts. Patients, compared with control subjects, had lower brachial FMD (7.16±3.4% versus 8.62±2.3%, respectively; P =0.02) and NTG (11.46±4.3% versus 13.21±4.6%, respectively; P =0.046) and higher brachioradial PWV (9.17±3.1 versus 8.06±1.9 m/s, respectively; P =0.05). In contrast, posterior tibial FMD, NTG, and lower limb PWV were comparable. Age (months) at the time of repair was related to brachioradial PWV ( r =0.42, P =0.002) but not to brachial FMD or NTG. Conclusions Patients with repaired aortic coarctation have impaired conduit artery function, with abnormal responses to flow and NTG, and increased vascular stiffness confined to the upper part of the body. Early repair is associated with preserved elastic properties of conduit arteries, but reduced reactivity remains.