tbuckley/cabot-search huggingface dataset:
Phase I study of OSI-906, dual tyrosine kinase inhibitor of insulin-like growth factor-1 receptor (IGF-1R) and insulin receptor (IR) in combination with erlotinib (E) in patients with advanced solid tumors.
Authors: V. M. Macaulay, M. R. Middleton, S. G. Eckhardt, R. A. Juergens, C. M. Rudin, A. Manukyants, S. Gogov, S. Poondru, R. Gedrich, S. M. Gadgeel
Journal: Journal of Clinical Oncology (2011)

3098^ Background: OSI-906 is an oral inhibitor of IGF-1R and IR tyrosine kinases. IGF-1R:EGFR cross-talk contributes to resistance to agents targeting either pathway, supporting trials of dual receptor inhibition. Methods: Sequential cohorts received escalating doses of OSI-906 + E (100 or 150 mg/d). Objectives included MTD determination, safety, response and PK/PD. Three dosing schedules (S) were investigated; S1: intermittent OSI-906 QD 1-3 q7 d at 50-600 mg + E; S2: continuous OSI-906 QD at 50-400 mg + E; and S3: continuous BID OSI-906 at 100 and 150 mg + E. Results: To date, 94 pts have been enrolled (47 M/47 F, median age 61 yrs) and 90 treated, with toxicity data in 79. In S1 (n=40) DLTs were G4 ALT/AST and G3 hyperglycemia in 2 pts at OSI-906 600 mg + E 100 mg; G3 ALT/AST in 1 pt at 450+100 mg; and G3 hyperglycemia, and G3 QTc prolongation in 2 pts at 450+150 mg. Evaluation at 400+150 mg is ongoing. DLTs in S2 (n=24) were asymptomatic G3 QTc prolongation in 2 pts at 400+100 mg. DLT in S3 (n=12) was G3 anorexia at 150+150 mg. Transient G1-2 hyperglycemia (53 pts, 67%) and hyperinsulinemia (15 pts, 19%) were consistent with IR inhibition. QTc prolongation related to OSI-906 was reported in 6 pts (8%). E-related skin changes occurred in 51 (65%) pts, with rash in 62% pts, pruritus and dry skin in 23% each. Other therapy-related AEs were diarrhea (56%), fatigue (49%), nausea (44%), anorexia (22%), and vomiting (20%). PK data show no substantial drug-drug interaction. PD effects of OSI-906 were observed after co-administration with E. Four pts had partial response: 1 pt at S2 50+100 mg (spinal chordoma), 2 at S1 450+150 mg (NSCLC, anal cancer) and 1 pt at S3 150+150 mg (NSCLC). Stable disease (SD) 12+ weeks was seen in 17/71 pts (24%), of whom 4/33 (12%) were on intermittent (S1) and 13/38 (34%) on continuous (S2 and S3) OSI-906. Conclusions: OSI-906 and E are well-tolerated and associated with prolonged SD and tumor regression. MTD and recommended phase II dose/schedule was determined as S3 OSI-906 150 mg BID + E 150 mg QD. A NSCLC expansion cohort (14 pts) is evaluating exploratory biomarkers, and additional NSCLC studies are ongoing with this combination.
Abstracts
Journal: Annals of the Rheumatic Diseases (1962)

30, 230), evidence was obtained which suggested that such relapses represented the reappearance of the inflammation that had been suppressed during therapy.In the present study, 88 patients aged 4 to 18 years who had not received anti-inflammatory therapy for one month and who then showed no clinical evidence of active rheumatic disease were given experimental re-treatment for a period of 2 weeks.Consecutive patients were allocated to one of three treatment groups which received respectively: prednisone in a dosage of 60 mg.per day for one week and 40 mg.per day for the second week (29 patients); aspirin, 0 75 gr.per lb.(110 mg. per kg.) body weight per day for one week and 0 5 gr.per lb.(70 mg. per kg.) per day for the second week (29 patients); the remaining thirty patients received no therapy and served as controls.On cessation of therapy, clinical relapse was observed in nine of the patients who had received prednisone, in one who had received aspirin, and in none in the control group.Laboratory relapse (shown by a rise either in the erythrocyte sedimentation rate or in the C-reactive protein level) occurred in thirteen, three, and three patients in the three groups respectively.In the prednisone-treated group the incidence of relapse depended to some extent on the nature of the cardiac condition.Thus relapses occurred in three of eleven patients with no valvular involvement, in two of eleven with valvular tedious to children.
Abstract 2545: Clinical Value of Multidetector Computed Tomography for Early Evaluation of Myocardial Viability, Left Ventricular Remodeling and Prognosis After Acute Myocardial Infarction
Authors: Akira Sato, Toshihiro Nozato, Hiroyuki Hikita, Hirokazu Ohigashi, Mieko Tamura, Atsushi Takahashi, Michiaki Hiroe
Journal: Circulation (2007)

Background: The clinical value of multidetector computed tomography (MDCT) in assessing myocardial reperfusion after acute myocardial infarction (AMI) is currently unclear. We aim to validate the ability of MDCT for assessing myocardial viability and predicting left ventricular (LV) remodeling after AMI. Methods: In 52 consecutive patients with first AMI, 64-slice MDCT without iodine reinjection was performed immediately after selective coronary angiography. ECG-gated thallium-201 SPECT was performed using QGS programs within 5 days and 6 months after onset. Transmurality and extent of myocardial delayed enhancement (DE) were assessed, and results combined with angiographic, SPECT, clinical follow-up data at 6 months to evaluate functional and prognostic significance of DE findings. Results: Among the 52 patients, 18 patients (Group A) showed transmural contrast DE, 20 patients (Group B) showed subendocardial contrast DE, and 14 patients (Group C) had no contrast DE. In the acute phase, peak CK-MB (483 ± 286, 223 ± 155, 129 ± 117 IU/ml, respectively, p = 0.0017) was significantly higher in Group A, while the incidence of myocardial blush grade 3 (22, 67, 75%, respectively, p = 0.0071) and LV ejection fraction (41 ± 8, 53 ± 13, 62 ± 11%, respectively, p &lt; 0.001) were significantly lower in Group A. During the 6-month period, LVEDV increased significantly (110 ± 25 to 125 ± 21 mm 3 , p = 0.042) in Group A, and LV remodeling ( p = 0.0064) and the number of re-hospitalization for heart failure ( p = 0.0121) was more significantly observed in Group A. Conclusions: Myocardial contrast DE patterns provide promising information regarding myocardial viability, LV remodeling and prognosis in AMI.
Incorrect Data and Wording in: Patient-Reported Symptoms and Quality of Life During Treatment With Tamoxifen or Raloxifene for Breast Cancer Prevention: The NSABP Study of Tamoxifen and Raloxifene (STAR) P-2 Trial
Authors: Robert Harrington, John Alexander, Judith Hochman, Harmony Reynolds, Vladimir Dzavik, Frans Van De Werf
Journal: JAMA (2007)
ESGE News and Upcoming Events April 2017
Journal: Endoscopy (2017)

ESGE Days 2018 offers a brand new and very exciting educational programme that is entirely focused on gastrointestinal endoscopy. The organizing committee is working hard to develop an amazing, multi-faceted programme which will address the full spectrum of endoscopic techniques and technologies catering to both early career as well as well-established practitioners. As part of this multi-faceted programme, on the first day of the congress, ESGE has dedicated meeting space to host a full day session of the Hungarian Society of Gastroenterology (HSGE). Conducted in Hungarian, this session will include presentations on topics including gastric cancer, chronic pancreatitis, therapy resistant GERD, as well as the roles of therapeutic endoscopy vs. surgery in selected conditions. The HSGE session will run in parallel to other endoscopy sessions including “hands-on endoscopy training” and an Academic Skills Course.
A Method for Predicting Postoperative Speech Reception Threshold
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Deaths
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Predicting pathological stage of localized prostate cancer
Authors: J. Naitoh
Journal: JAMA (1997)

<h3>To the Editor.</h3> —Dr Partin and colleagues<sup>1</sup>recently updated their experience using prostate-specific antigen (PSA) level, clinical stage, and tumor grade for predicting the pathological stage of prostate cancer determined at the time of radical prostatectomy. The authors are to be commended for this herculean effort. However, in examining our own series of radical prostatectomies, our data did not correspond to the outcomes listed in the article. Focusing the analysis of tumors with a Gleason score of 6 or 7, clinical stage of T2b, and PSA levels ranging between 4 and 10 ng/mL, the chance of having organ-confined disease was greater than that reported by Partin et al (70% vs 38% for tumors with Gleason scores of 6 and 50% vs 22% for tumors with Gleason scores of 7). This may be because of the high rate of interobserver variability that exists in clinical staging based on the digital
Biochemistry of Viral Infection
Authors: Morton N. Swartz, John W. Littlefield
Journal: New England Journal of Medicine (1960)

Eclipse PhaseAlterations in General Host-Cell Metabolism upon InfectionBecause it is as yet technically impossible to infect single cells, studies on chemical changes in host cells with plant-virus infections, such as tobacco mosaic virus, have been limited. The evidence has suggested that respiration in healthy and virus–infected plants is essentially similar, although there have been some studies to suggest increased respiration in infected plants. The amount of tobacco mosaic virus formed in infected plants may reach considerable proportions, amounting to as much as 10 per cent of the dry weight of the diseased leaves. This viral synthesis is paralleled . . .
Tattoo-Related Brachial Plexopathies with Adjacent Muscle Atrophy
Authors: Israel Steiner, Itzhak Wirguin
Journal: Annals of Internal Medicine (2001)

Letters17 April 2001Tattoo-Related Brachial Plexopathies with Adjacent Muscle AtrophyIsrael Steiner, MD and Itzhak Wirguin, MDIsrael Steiner, MDHadassah University Hospital; Jerusalem 91120, Israel (Steiner)Soroka Medical Center; Beer Sheva 84101, Israel (Wirguin)Search for more papers by this author and Itzhak Wirguin, MDHadassah University Hospital; Jerusalem 91120, Israel (Steiner)Soroka Medical Center; Beer Sheva 84101, Israel (Wirguin)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-134-8-200104170-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We appreciate Dr. Post's point. No doubt, tattoos carry the risk for transmission of infection. Two of our patients were negative for hepatitis B virus infection (the third one was lost to follow-up before work-up). Although the possibility of another infection cannot be ruled out, the relatively long latency period between the procedure and appearance of the neurologic findings does not support this possibility. Author, Article, and Disclosure InformationAffiliations: Hadassah University Hospital; Jerusalem 91120, Israel (Steiner)Soroka Medical Center; Beer Sheva 84101, Israel (Wirguin) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoTattoo-Related Brachial Plexopathies with Adjacent Muscle Atrophy Israel Steiner , Peter Farcas , and Itzhak Wirguin Tattoo-Related Brachial Plexopathies with Adjacent Muscle Atrophy Jeffrey John Post Metrics 17 April 2001Volume 134, Issue 8Page: 715KeywordsAtrophyHepatitis BMuscles ePublished: 17 April 2001 Issue Published: 17 April 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
PERCENTAGE OF POSTMORTEM EXAMINATIONS OF HOSPITALS
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Head and Neck Surgery
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BOOK REVIEWS
Journal: British Journal of Dermatology (1963)

British Journal of DermatologyVolume 75, Issue 12 p. 501-503 BOOK REVIEWS First published: December 1963 https://doi.org/10.1111/j.1365-2133.1963.tb13936.xAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Book reviews in this article: Investigations into Dyshidrosiform Eruptions. R. D. G. P. Simons. A Comparative Study of Skin Diseases in Dog and Man. R. M. Schwabtzman and M. Orkin. Congenital Abnormalities in Infancy. Ed. A. P. Norman. Clinical Genodermatology. T. Butterworth. and L. P. Strean. Volume75, Issue12December 1963Pages 501-503 RelatedInformation
Oval cell differentiation into hepatocytes in the acetylaminofluorene-treated regenerating rat liver
Authors: Matthew Golding, Catherine E. Sarraf, El-Nasir Lalani, T. V. Anilkumar, Robert J. Edwards, Peter Nagy, Snorri S. Thorgemsson, Malcolm R. Alison
Journal: Hepatology (1995)

When hepatocyte regeneration after a two-thirds partial hepatectomy (PH) in rats is blocked by oral gavage of acetylaminofluorene, a proliferation of ductular cells ensues that results in a profusion of neoductules radiating from each portal tract. To examine the possibility that this population of newly emerging cells harbors cells capable of differentiating into hepatocytes, we have looked in these cells for expression of functional markers of hepatocyte commitment at both the RNA and protein levels. Expression of albumin and α-fetoprotein (α-FP) messenger RNA (mRNA) transcripts were sought in situ using antisense riboprobes, and the expression of a number of cytochrome P450 enzymes was examined immunohistochemically. Before any signs of differentiation the ductular cells strongly expressed cytokeratins 7, 8, 18, and 19 in the same manner as authentic bile ducts, but unlike the latter also expressed vimentin. In situ hybridization studies showed that small bile ducts close to the limiting plate, as well as the newly formed ducts, expressed albumin and α-fetoprotein messenger RNAs, and immunocytochemistry showed that the distribution of the respective proteins was similar. Beginning at 1 week after partial hepatectomy, areas of differentiation could be found in the new ducts, with cells resembling either columnar intestinal-type epithelia or hepatocytes. Intestinal-like cells expressed neither albumin, α-FP, nor cytochrome P450 enzymes, whereas ductular cells appearing like hepatocytes with the typical membranous distribution of cytokeratin 8 strongly expressed a variety of cytochrome P450 enzymes normally associated with functional hepatocytes. These observations further support the belief that reactive ductules, sprouted from small ducts, can represent an adaptive response of the liver to replenish lost hepatocytes, although some of the newborn cells appear to differentiate along intestinal lines. (Hepatology 1995; 22:1243-1253.).
Official Call
Journal: JAMA (1975)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Do You Want to be a Nurse?
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
UNITED KINGDOM
Journal: JAMA (1963)

<h3>A Holbein Rendering Discovered.</h3> —W. R. Le Fanu (<i>Brit Med J</i>[Jan 12] 1963) pointed out that the version of Holbein the Younger's (1497-1543) "Henry VIII with the Barber-Surgeons" belonging to the Royal College of Surgeons of England has long excited curiosity. It was bought by the Company of Surgeons, predecessor of the Royal College, in 1786. "If it was then new, why is it not a precise copy of the original Great Picture which the Barbers Company has owned since the sixteenth century? If it was not new, where had it been lurking unobserved?" The records of the Company of Surgeons show that the Master bought in 1786 for 50 guineas "in a late sale of pictures of Monsieur Desenfans, a large and Capital Picture, being a Cartoon* painted by Hans Holbein representing King Henry VIII delivering the Charter to the Barber-Surgeons... being satisfied of its undoubted Authenticity and