tbuckley/cabot-search huggingface dataset:
Leaning upon International Directives for Optimization: Anemia—Results of the French LIDOanemia survey.
Authors: Florian Scotte, Nicolas Janus, Lisa Ludwig, Gilbert Deray, Vincent Launay-Vacher
Journal: Journal of Clinical Oncology (2015)

e20739 Background: Anemia in cancer patients is common and may present with multiple etiologies, including cancer itself, chemotherapy, iron functional deficiency, erythropoietin deficiency due to underlying renal disease. Its treatments include iron supplementation (IS), erythropoiesis-stimulating agents (ESAs), and red blood cell (RBC) transfusion. National/international recommendations are available, but not always followed in the clinical practice setting. Methods: Declarative survey conducted in France (07/10/2014 -04/11/2014). Answers were collected and registered into a web-based server. Results: 977 physicians were contacted among which 13.6% answered the survey. Anemia was defined by an hemoglobinemia (Hb) < 12 g/dL for half of the respondents (Table). The characterization of anemia was performed with Hb, serum ferritin and transferrin saturation for 34%. The initiation of ESAs was considered for a Hb value < 11 g/dL for only 26.8%. RBC transfusion were considered for Hb < 9 for only 10.2%. A transferrin saturation < 20%, a serum ferritin < 100 or 300 µg/L, was considered for initiation of IV IS in 65.8, 43.0, and 40.5%, respectively. ESA and IV IS are to be used together for 63.2%. Target Hb under treatment was 12 g/dl (49.1%), 36.6% of the physicians had a lower target Hb and 11.2% did not have any. Conclusions: This declarative survey shows that the clinical practice in France for the management of cancer anemia diverges from EORTC guidelines for the initiation of ESA/transfusion therapy. ESA and RBC transfusions are initiated for lower Hb values as compared to EORTC guidelines. This is probably one of the reasons why still today, approximately half of cancer patients still present with uncontrolled/untreated anemia [Launay-Vacher MASCC 2014]. Furthermore, only half of the physicians considered the recommended Hb target of 12 g/dL, others targeting lower values. Table. Main results of the LIDO survey Hb cut-off values (g/dL) Anemia definition* ESA Initiation Transfusion initiation Target Hb < 13 1.7% - - 0.0% < 12 50.0% 5.2% 0.0% 49.1% < 11 21.7% 26.8% 1.0% 24.1% < 10 20.0% 42.3% 1.0% 15.5% < 9 - 6.2% 10.2% 0.0% < 8 - 16.5% 80.6% 0.0% < 7 - 3.1% 7.1% - *Other: 6.7%; bold: EORTC guidelines.
SHMOs grading review
Authors: G Davidson, Alma Simmonds, F Abdul, Jabbar Abeysirigunawardana, A El-M Abu-Omar, M Adams, C Ajomo, G Aletor, M Ali, S Al-Malaika, A Al-Meshari, E Ayanka, M Balsdon, J Barr, A Bateman, N Begum, J Bevan, J Bolton, J Brash, Pamela Buck, A Chakrabarti, D Chakrabortti, Y Chaudhuri, P Cheung, D Coats, M Corvin, G Damole, B Dikshit, H Ejiumudo, A El, A El-Awady, A El-Farra, A El-Gaaly, K El-Ghonaimy, I Fabunmi, H Farquhar, J Fassler, K Fong, J Ford, R Frazer, T Gaafar, F Gasde, M Graham, R Green-Thompson, N Hambly, C Harmston, R Haskins, G Hastwell, Kathleen Jennison, J Kane, L Kapadia, K Karia, J Kasule, A Kent, C Kessy, M Kleida, T Kopenhager, P Labanya, T Lee, Catherine Lim, Olivia Lore, E Mcdonald, J Mcguinness, A Mclaughlin, F Mander, N Naidoo, U Nath, R Neale, R Nelson, L Ng, Grace North, J Nwaogbo, J Oats, I Obineche, K Patel, G Paul, Eleanor Pickering, A Pinshaw, J Pogmore, W Reid, H Rodeck, S Saigol, U Sathia, C Sornalingam, E Speck, M Srivastava, G Storey, S Thekkemadathil, A Tikreeti, C Van, Der Merwe, S Van, P Vinall, L Wald, J Walton, D Wilde, M Wolfson, J Wontumni, R Young-Thompson, M El, T Youssif
Journal: BMJ (1975)
The Neonatal Behavioral Assessment Scale as a Biomarker of the Effects of Environmental Agents on the Newborn
Authors: Edward Z. Tronick
Journal: Environmental Health Perspectives (1987)

The organization of the newborn's brain and the nature of the effects of toxins and pollutants conspire to produce complex and difficult problems for the assessment of the behavioral effects of environmental agents. The newborn's brain can be characterized as relatively undifferentiated, and more vulnerable to, but potentially more capable of recovery from, the effects of environmental agents specific to this time period than it will be later in development. Environmental agents tend to have nonspecific, possibly subtle, effects that invade many areas of newborn functioning. These characteristics of the newborn and the behavioral effects of teratogens make assessment at this point in development difficult. Further exacerbating this difficulty is the nature of development. Development is critically dependent on the care the newborn receives. Distortions of a newborn's behavior can produce disturbances in the caretaking environment, and these caretaking disturbances can amplify the original behavioral distortion and produce other distortions. Attention to these types of effects must be built into an assessment. These considerations lead to the conclusion that an apical assessment of newborn behavior is required. The most standardized, valid, and reliable instrument currently available is the Neonatal Behavioral Assessment Scale developed by Brazelton. It assesses the integrated actions of the infant that function to regulate simultaneously the infant's internal state and exchanges with the animate (caretaking) and inanimate environment. The scale uses a set of reflex and behavioral items to assess the critical domains of infant functioning (e.g., the infant's ability to control his states of consciousness).(ABSTRACT TRUNCATED AT 250 WORDS)
CHEMOTHERAPY IN SUBACUTE BACTERIAL ENDOCARDITIS
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells
Authors: Yoshihiro Inami, Satoshi Waguri, Ayako Sakamoto, Tsuguka Kouno, Kazuto Nakada, Okio Hino, Sumio Watanabe, Jin Ando, Manabu Iwadate, Masayuki Yamamoto, Myung-Shik Lee, Keiji Tanaka, Masaaki Komatsu
Journal: The Journal of Experimental Medicine (2011)
A New Hemagglutination Procedure for Diagnosis of Active Tuberculosis
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dialyser gaskets.
Authors: B M Tobin, A J Ralston, D M Jones
Journal: BMJ (1970)

JOHRNALconcentrate available resources into fewer and larger units."Mr. Roper's report was dealing with the office of Health Economics' latest publication Building for Health.This wellconsidered document, the result of wideseeking research, seriously challenges the concept of huge hospitals and suggests that resources would be better employed in the development of about 1,000 community care units.Any one properly interested in the future pattern of hospitals (and therefore in the future pattern of medical care because the two are intimately related) would know that the subject is very much open and the decisions involved are ones that will profoundly affect all of us, both as doctors and as potential patients for the next half century or more.May I ask, therefore, through your col- umns if the originator of this press pro- nouncement will reveal himself, and also the authority on which he bases his "wis- dom.
Committee on Foods
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Archives of Dermatology, Chicago
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Recombinant glutamine synthetase reduces ammonia and hepatic fibrosis in in vitro and in vivo models of non-alchoholic fatty liver disease
Authors: Antria Siakalli, Abeba Habtesion, Andrew Hall, Ewald Doornebal, Dr. Elena Palma, Tamara Nicolson, Shilpa Chokshi, Jane Macnaughtan, Rajiv Jalan
Journal: Journal of Hepatology (2020)
Circulation/Cardiology
Authors: R. G. Grabitz, J. Y. Coe, R. Chen, J. Timinsky, G. von Bernuth, Xiang-Qing Yu, Bjørn Aage Feet, Atle Moen, Pilvi Ilves, Ola Didrik Saugstad, R. C. Wetzel, S. Demirakça, Ch. Knothe, K. J. Hagel, J. Bauer, P. Kunovský, L. Kováčikova, M. Csader, J. Siman, F. Gutiérrez-Larraya, A. Mendoza, J. M. Velasco, C. Zavanella, A. Galindo, R. Sánchez-Andrade, J. I. Sánchez, A. Melián, F. Mar
Journal: Intensive Care Medicine (1996)
Metabolic and genetic risk factors predict advanced alcohol-related liver fibrosis regardless of drinking pattern
Authors: Mads Israelsen, Helene Bæk Juel, Sönke Detlefsen, Bjørn Stæhr Madsen, Maria Kjærgaard, Mary Jo Fernandez Jensen, Stefan Stender, Aleksander Krag, Torben Hansen, Maja Thiele
Journal: Journal of Hepatology (2020)
"SMOKING IS ASSOCIATED WITH AN AGE-RELATED DECLINE IN EXHALED NITRIC OXIDE". J.S. SUNDY, D.W. HAUSWIRTH, S. MERVIN-BLAKE, C.A. FERNANDEZ, K.B. PATCH, K.M. ALEXANDER, S. ALLGOOD, P.D. MCNAIR AND M.C. LEVESQUE. EUR RESPIR J 2007; 30: 1074-1081.
Journal: European Respiratory Journal (2008)
Scombroid Fish Poisoning—New Mexico, 1987
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Decline in Student Tobacco Use
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Geriatric Services
Authors: JOSEPH C. HONET
Journal: Annals of Internal Medicine (1980)

Letters1 April 1980Geriatric ServicesJOSEPH C. HONET, M.D.JOSEPH C. HONET, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-92-4-569_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We in the specialty of physical medicine and rehabilitation are quite involved in the practice of geriatric medicine. Many of the features of a modern geriatric service suggested by James Williamson in his article "Geriatric Medicine: Whose Specialty?" (1) are services performed in the specialty of physical medicine and rehabilitation. We certainly are involved in coordinated service based on a multidisciplinary team. We are quite involved in the provision of a range of activities such as home-visiting for clinical, social, and psychiatric assessment in the patient's own setting and, occasionally, involved in day-hospital care. We are certainly...Reference1. WILLIAMSON J. Geriatric medicine: whose specialty? Ann Intern Med. 1979;91:774-7. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1980Volume 92, Issue 4Page: 569-569KeywordsGeriatric rehabilitationGeriatricsRehabilitation medicine Issue Published: 1 April 1980 PDF DownloadLoading ...
Modifikatsiya operatsii Razumovskogo na yaichke; eksperimentalnoe issledovanie
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
QUANTITATIVE EXPERIMENTS WITH ANTIBODIES TO A SPECIFIC PRECIPITATE. I
Authors: Henry P. Treffers, Michael Heidelberger
Journal: The Journal of Experimental Medicine (1941)

1. Rabbits were injected with the washed specific precipitate from Type II antipneumococcus horse serum. Antibody in the resulting antiserum was determined by the quantitative agglutinin method using various specific precipitates as antigens. 2. Suspensions of Types I and II antipneumococcus horse specific precipitates, as well as the specific precipitates derived from Type VIII Pn (anti-C portion), and H. influenzae horse antisera were found to remove the same amount of antibody from the immune rabbit serum. 3. Purified antibody solutions prepared by dissociation methods from Types I and II antipneumococcus horse sera were found to remove the same quantity of antibody as did the homologous specific precipitates. 4. Specific precipitates from anti-crystalline egg albumin and anti-diphtheria horse sera were found to remove only a fraction of the antibody. The reasons for this are discussed. 5. A specific precipitate prepared from pepsin-digested Type I anti-pneumococcus horse serum removed all of the antibody to the homologous antigen from the rabbit anti-precipitate serum, but followed a different quantitative course. 6. From the quantitative course of these reactions and from experiments with specific precipitates from anti-Pn rabbit and pig sera it is concluded that the only antigenic specificity demonstrable for the antibodies investigated was that due to their common origin, and that the groupings responsible for their antibody function constitute either a small part of the total protein molecule or else are non-antigenic.
Allergy to hymenoptera stings
Authors: S. E. Barr
Journal: JAMA (1974)

Allergy to Hymenoptera stings may be severe or even fatal. Records were examined of 249 insect-allergic patients seen over 12 years. Evaluation included careful history taking. Intradermal skin tests were of value in diagnosis and treatment, but correlation with history was imperfect. Patients were instructed in methods to decrease the possibility of subsequent stings and given emergency treatment kits containing epinephrine. Results of hyposensitizing injections were excellent, with 303 of 308 subsequent stings resulting in less reaction than before beginning injections. (JAMA 228:718-720, 1974)
Abstract 793: The prometastatic effects of subcytotoxic doses of doxorubicin are countered by agents inactivating mitochondrial reactive oxygen species
Authors: Paolo E. Porporato, Pierre Sonveaux
Journal: Cancer Research (2019)

Abstract Mitochondrial reactive oxygen species (mtROS) possess both tumor-promoting and tumor-suppressive activities according to their net concentration resulting for production levels and antioxidant detoxification. mtROS promote cancer cell fitness at low doses (mitohormesis), are cytotoxic at high doses and promote cancer migration, invasion and metastasis at intermediate doses. These intracellular doses vary from a model to another. Yet, we recently identified that mitochondria-targeted ROS scavengers mitoTEMPO and mitoQ prevent cancer metastasis in several in vivo models (Porporato et al. Cell Reports 2014;8:754-66). Interestingly, several anticancer drugs, among which doxorubicin, are well known to trigger mtROS production in cancer cells, but whether this response participates in cell killing or in resistance is still debated. We therefore tested whether combining mitochondria-targeted antioxidants with doxorubicin could help controlling cancer cell proliferation in vitro and tumor growth in mice. Using breast cancer cells lines MCF7 and 4T1 as models, we first found that subcytotoxic doses of doxorubicin increased cell respiration and, thereby, mitochondrial superoxide production. Downstream, mtROS activated the TGFβ pathway and induced cancer cell migration, invasion, epithelial-mesenchymal transition (EMT) and metastatic take in lungs. MitoTEMPO and mitoQ almost totally blocked these phenotypical changes. Together, our data provide a strong rationale for combining doxorubicin chemotherapy with drugs lowering mtROS production in breast cancer. Citation Format: Paolo E. Porporato, Pierre Sonveaux. The prometastatic effects of subcytotoxic doses of doxorubicin are countered by agents inactivating mitochondrial reactive oxygen species [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 793.