tbuckley/cabot-search huggingface dataset:
CRAF Has MEK-Independent Functions in Mitosis and Tumor Progression
Journal: Cancer Discovery (2011)

Abstract Major finding: CRAF has a direct role in mitosis that does not require the RAF effector MEK. Mechanism: CRAF interacts with PLK1 and promotes its activity and accumulation at kinetochores. Impact: Allosteric RAF inhibitors that block phospho-Ser338 CRAF may be effective cancer therapies.
Neurology
Authors: Robert J. Joynt
Journal: JAMA (1996)

The pace of new information about the basis of neurological disease and new treatment possibilities continues to accelerate. I have practiced neurology for 40 years. Treatment options in the 1950s were few, and notions about causation were rudimentary. Some in our profession are jaded by the changes in medical practice, but I find that it has become more exciting and fulfilling with our expanding knowledge. In this past year there has been activity in several areas, but only a few will be highlighted. Stroke, especially ischemic stroke, continues to be a major killer and crippler. Most of the efforts have been spent in prevention, because little can be done once the stroke occurs. Two major trials of treatment of the acute stroke with tissue-type plasminogen activator (t-PA) have been completed.<sup>1,2</sup>Both studies were randomized, double-blind trials, and treatment with t-PA or placebo was started by 6 hours after the
TROUBLED WATERS
Journal: JAMA (1968)

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CDC Offers Investigational Drug
Journal: JAMA (2013)

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The Pritikin diet
Authors: N. Pritikin
Journal: JAMA (1984)

<h3>To the Editor.—</h3> Since 1976,<i>JAMA</i>has consistently reported the Pritikin Program unfairly. I thank Dr Lundberg for this opportunity to set the record straight, at least on the most recent examples. In 1981,<i>JAMA</i>reported a study by Hutchison and Brown in an article entitled "Pritikin vs AHA Diet: No Difference for Peripheral Vascular Disease."1 The so-called Pritikin diet used in the study was neither the Regression diet used at my centers and in all my research since 1974 nor the Maintenance diet described in my books meant for asymptomatic patients. My diet guidelines are as follows: less than 10% fat, 10% to 15% protein, 75% to 80% mainly complex carbohydrates, less than 25 mg of cholesterol (Regression diet), and less than 100 mg of cholesterol (Maintenance diet). Hutchison's subjects consumed<i>twice</i>the fat and<i>three times</i>the cholesterol permitted on my more lenient Maintenance diet for well people!
Smooth Muscle Cytochrome b5 Reductase 3 Deficiency Accelerates Pulmonary Hypertension Development in Sickle Cell Mice
Authors: Katherine Wood, Brittany Durgin, Heidi M Schmidt, Scott Hahn, Jeffrey Baust, Tim Bachman, Dario A. Vitturi, Samit Ghosh, Solomon Fiifi Ofori-Acquah, Ana Mora, Mark T Gladwin, Adam Straub
Journal: Blood (2019)
Opposition to Harvey's Views
Journal: JAMA (1987)

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Software
Authors: Alan F. Aronson
Journal: JAMA (1990)

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HOSPITAL PHYSICIANS' ORGANIZATION.
Journal: JAMA (1893)

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Rupture of Aortic Valve Secondary to Aneurysm of Ascending Aorta
Journal: JAMA (1963)

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Overdose of Dese and Dose
Journal: JAMA (1972)

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Reply
Authors: K E L McColl, G M Fullarton
Journal: Gut (1994)

Lettersfind such a good correlation between motility and ulcer pain8 9 and although in our own studies the use of an anti-spasmodic did not affect the development of acid induced duodenal ulcer pain,6 we feel that duodenal wall tension or dysmotility deserve further study as a possible cause of duodenal ulcer pain and a possible explanation for the imperfect correla- tion between the pH around the ulcer crater and development of ulcer pain in patients with symptomatic duodenal ulcer.
The oncoprotein gankyrin binds to MDM2/HDM2, enhancing ubiquitylation and degradation of p53
Authors: Hiroaki Higashitsuji, Hisako Higashitsuji, Katsuhiko Itoh, Toshiharu Sakurai, Toshikazu Nagao, Yasuhiko Sumitomo, Tomoko Masuda, Simon Dawson, Yutaka Shimada, R. John Mayer, Jun Fujita
Journal: Cancer Cell (2005)
NEW FACTS IN REGARD TO VITALITY.
Journal: JAMA (1898)

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New York State Medical Association.
Journal: JAMA (1893)

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A Review: Hemodynamic Response to Carbon Monoxide
Authors: David G. Penney
Journal: Environmental Health Perspectives (1988)

Historically, and at present, carbon monoxide is a major gaseous poison responsible for widespread morbidity and mortality.From threshold to maximal nonlethal levels, a variety of cardiovascular changes occur, both immediately and in the long term, whose homeostatic function it is to renormalize tissue oxygen delivery.However, notwithstanding numerous studies over the past century, the literature remains equivocal regarding the hemodynamic responses in animals and humans, although CO hypoxia is clearly different in several respects from hypoxic hypoxia.Factors complicating interpretation of experimental findings include species, CO dose level and rate, route of CO delivery, duration, level of exertion, state of consciousness, and anesthetic agent used.For example, tachycardia is commonly observed, although bradycardia also can result from myocardial and/or central nervous system (CNS) hypoxemia at high carboxyhemoglobin (COHb) saturations, as can electrocardiographic abnormalities.Augmented cardiac output usually observed with moderate COHb may be compromised in more severe poisoning for the same reasons, such that regional or global ischemia result.The hypotension usually seen in most animal studies is thought to be a primary cause of CNS damage resulting from acute CO poisoning, yet the exact mechanism(s) remains unproven in both animals and humans, as does the way in which CO produces hypotension.This review briefly summarizes the literature relevant to the short-and long-term hemo- dynamic responses reported in animals and humans.It concludes by presenting an overview using data from a single species in which the most complete work has been done to date.
Clinical Observations on the Antihypertensive Effect of Pargyline Hydrochloride
Journal: JAMA (1963)

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Poster Sessions 602-806
Authors: P Plasil, J Carrera
Journal: Intensive Care Medicine (2004)

INTRODUCTION:The aim of this clinical trial is to study pneumothorax (PNTH) complicating mechanical ventilation (MV) in elderly ICU patients (pts). METHODS:We studied retrospectively 96 ICU pts, 84 men (87.5%)-12 women (12.5%) who developed PNTH due to MV. Mean age: 45.2±19.8years.Mean stay: 12.3±5.1 days.Underlying diseases: multiple trauma without thoracic injury 47, complicated surgery 34, vascular cerebral accident 8, other 7. Pts with thoracic injury, thoracic surgical procedures and insertion of central venous catheter in the internal jugular or subclavian vein were excluded.Ten pts (10.4%) had COPD.All pts underwent MV and were divided according to their age in 2 groups: Group A 62 (64.6%) ≤ 65 years old and group B 34 (35.4%)> 65 years.We used clinical and laboratory findings for the diagnosis of PNTH (thorax auscultation, blood gases, chest X-ray on pts' bed, CVP, pulmonary resistance, deterioration of respiratory failure), while in 6 pts (6.2%) PNTH was diagnosed after a thorax CT scan. RESULTS:In groups A and B respectively: Mean age 29.2±16.1 and 74.4±4.2 years.Mean stay 11.4±4.7 and 13.9±3.6days.Mean duration of MV until PNTH occurred: 4.0±2.2 and 6.5±2.2 days.Mean compliance 34.3±9.2 and 42.4±12.6ml/cm H2O.Mean airway inspiratory pressure before PNTH occurred: 42.3±7.6 and 38.5±6.9 cm H2O.Subcutaneous emphysema in 5 (8.1%) and 3 (8.8%).Chest X-ray not diagnostic of PNTH in 2 (3.2%) and 4 (11.8%).The treatment of PNTH was successful in all pts.CONCLUSION: a) Chest X-ray on pts' bed did not always reveal PNTH and rarely a thorax CT scan was needed.B) In elderly PNTH occurred after longer duration of MV (p<0.05), but always before the 11th day and mainly in pts with low compliance.We mention that in elderly compliance was higher (p<0.05).c) The mean airway inspiratory pressure just before PNTH was lower in elderly, but not in statistically significant degree (p<0.1),It is important to maintain inspiratory pressure in MV as low as possible.D) PNTH did not influence the outcome of pts in both groups.
Visualization of Thyroid Tissue by Contrast Angiography
Journal: JAMA (1963)

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&lt;TITLE&gt;Organ Donation&lt;/TITLE&gt;
Authors: Lise Stevens, Cassio Lynm, Richard Glass
Journal: JAMA (2001)

The JAMA Patient Page is a public service of JAMA.The information and recommendations appearing on this page are appropriate in most instances, but they are not a substitute for medical diagnosis.For specific information concerning your personal medical condition, JAMA suggests that you consult your physician.This page may be reproduced noncommercially by physicians and other health care professionals to share with patients.Any other reproduction is subject to AMA approval.
REVIEW OF THE HILLSDALE, MICH., TYPHOID FEVER EPIDEMIC OF 1920
Journal: JAMA (1921)

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