tbuckley/cabot-search huggingface dataset:
Abstract 170: Inflammation Imaging in the Primate Heart Using <sup>111</sup> In-Labeled Anti-Tenascin-C Antibody
Authors: Michiaki Hiroe, Naohide Ageyama, Yasuhiro Yasutomi, Hiroyuki Kurosawa, Ousuke Fujimoto, Yasushi Arano, Kyoko Imanaka-Yoshida
Journal: Circulation Research (2012)

Myocardial inflammation after myocardial infarction and myocarditis may cause cardiac remodeling, leading to congestive heart failure and arrhythmias. Tenascin-C (TNC), an extracellular matrix glycoprotein, is not normally expressed but specifically expressed associated with active inflammation. The aim of this study was to explore the myocardial expression of TNC after myocardial infarction in Macaca fascicularis (crab-eating monkey) using 111 In-labeled anti-TNC antibody ( 111 In-TNC-Fab’). The left coronary artery was permanently ligated in two monkies and 4 days later, we performed dual-isotope single-photon emission computed tomography imaging (SPECT) of 111 In-TNC-Fab’ and 99m Tc methoxy- isobutyl isonitrile (MIBI), and compared with those of an age-matched control. Then, dual autoradiography was compared with histology and immunostaining for TNC of the heart. Dual-isotope SPECT demonstrated the regional myocardial uptake of 111 In-TNC-Fab’ in the areas of decreased uptake of MIBI. On autoradiography, the radioactivities were observed in the border zone between the infarcted and the noninfarcted area of MI hearts. The hot spots corresponded with the positively immunostained areas. In contrast, no radioactivites of 111 In-TNC-Fab’ were detected in the control. These data clearly indicated that, using 111 In-TNC-Fab’, we can visualize the inflammatory lesions followed by myocardial infarction of the primate.
Highlights
Journal: JAMA (2015)

Improving Housing Stability for Mentally Ill Homeless Adults 905In a randomized trial involving 1198 homeless Canadian adults with mental illness, Stergiopoulos and colleagues found that compared with usual care, subsidized access to scattered-site housing and intensive case management resulted in increased housing stability over 24 months but no improvements in health-related quality of life.In an Editorial, Katz discusses interventions to address chronic homelessness.
Chronic Effects of Lead on the Renin-Angiotensin System
Authors: Arthur J. Vander
Journal: Environmental Health Perspectives (1988)

This paper reviews the chronic effects of lead exposure on the renin-angiotensin system in experimental animals and human beings. In rats, when lead exposure is begun several weeks after birth in doses that cause blood lead concentrations (PbB) of 30 to 40 micrograms/dL, the result is an increase in basal plasma renin activity (PRA) and renal renin concentration, with no change in the metabolic clearance of renin; this is presumptive evidence for increased renin secretion. PRA is also increased in 1-month-old animals whose exposure to lead (in doses that raise PbB to 9 micrograms/dL) was begun in utero. In contrast, older animals whose exposure was begun in utero manifest no change or a decrease in their PRA and renal renin concentration. Regardless of when the exposure is begun, lead can decrease the plasma concentration of angiotensin II at any given PRA, but the dose required for this effect is highly variable. The hypertension induced by lead exposure is associated with low PRA and a normal angiotensin II/PRA ratio. Chronic human exposure to lead also is associated with highly variable changes in PRA from study to study; it has been reported to be decreased under both basal and stimulated conditions, unchanged, or increased in a manner exponentially related to PbB. The human data are consistent with the tentative hypothesis that lead-exposed persons may have higher PRA than normal during the early periods of modest exposure but normal or depressed PRA following more chronic severe exposures. In a small preliminary study, blood lead concentration was found to be higher in high-renin hypertensive persons than in normotensive persons.
MALIGNANT PUSTULES.
Authors: Jno. W. Trader
Journal: JAMA (1885)

Sedalia, Mo., Jan. 20, 1885. <h3>Dear Journal:</h3> —In your issue of 17th inst., I notice a communication from Dr. Leech, Jefferson Medical College, relating to ulcers of fingers. While I do not approve of charging everything of this nature to syphilitic virus, it would certainly appear that in the cases cited there must have been some specific poison, as the ophthalmitis of the infant would clearly show. The character of the ulceration, also, in my mind, would suggest animal poison. Our literature upon the subject of localized pustulations is fearfully meagre, so far as causation is concerned. Having just had a patient suffering in like manner, I was fearful of grave results. No cause could be attributed for the local trouble. I was treating the patient for a neurosis. The general health was good. The disease first manifested itself as a small blood-blister, about as large as a split pea,
Enzyme detergents.
Journal: BMJ (1970)

Thus three factors-Clause 5, the records of the school health service (available under Clause 1 (6)), and the powers of Clause 2-will make it Dossible to institute a selective system of examining young persons.The Bill, like the Factories Act, 1961, addresses itself mainly to the duties of employers.They are instructed, for example, to make it possible for an employee to attend for medical examination when, in the opinion of the employment medical adviser, there ought to be a medical examination.
Third Annual Meeting of the Cell Kinetics Society
Journal: JNCI Journal of the National Cancer Institute (1979)

Journal Article Third Annual Meeting of the Cell Kinetics Society Get access JNCI: Journal of the National Cancer Institute, Volume 62, Issue 1, January 1979, Page 213, https://doi.org/10.1093/jnci/62.1.213c Published: 01 January 1979
Combined Alpha- and Beta-Sympathetic Blockade in Hyperthyroidism: Clinical and Metabolic Effects.
Authors: J. William Cox
Journal: Annals of Internal Medicine (1969)

s1 May 1969Combined Alpha- and Beta-Sympathetic Blockade in Hyperthyroidism: Clinical and Metabolic Effects.J. William Cox, M.D., F.A.C.P., Bill D. Stout, M.D., Leslie Wiener, M.D.J. William Cox, M.D., F.A.C.P.Search for more papers by this author, Bill D. Stout, M.D.Search for more papers by this author, Leslie Wiener, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-70-5-1061_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptClinical and metabolic effects of propranolol (4.6 to 10.3 mg/kg/day) and phenoxybenzamine hydrochloride (0.44 to 0.82 mg/kg/day) administered for an average of 71 days were studied in eight hyperthyroid patients. Body weight, oxygen consumption, kinemometric measurements of the Achilles reflex, serum lipids (cholesterol, triglycerides, and phopholipids) were studied. Common thyroid function tests including protein-bound iodine,131I-uptake, resin triiodothyronine uptake test, and131I scan of the thyroid gland were measured before and after treatment. Five normal male subjects (mean age, 22 years) given propranolol (3.2 to 5.0 mg/kg/day) and phenoxybenzamine hydrochloride (0.3 to 0.47 mg/kg/day) served as controls for oxygen consumption... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: J. William Cox, M.D., F.A.C.P.; Bill D. Stout, M.D.; Leslie Wiener, M.D.Affiliations: Philadelphia, Pennsylvania. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1969Volume 70, Issue 5Page: 1061-1061KeywordsBody weightCholesterolHyperthyroidismLipidsOxygen consumptionPhenoxybenzamineProteinsReflexesThyroidTriiodothyronine ePublished: 1 December 2008 Issue Published: 1 May 1969 PDF downloadLoading ...
Upper Respiratory Tract Infections Among Airline Passengers
Authors: M. Hocking
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Positron emission tomography in oncology. Council on Scientific Affairs
Authors: George M. Bohigian, E. Harvey Estes, Ira R. Friedlander, William R. Kennedy, John H. Moxley, Patricia J. Numann, Paul S. Salva, William C. Scott, Joseph H. Skom, Richard M. Steinhilber, Jack P. Strong, Henry H. Wagner, William R. Hendee, William T. McGivney, Joanna S. Fowler, Edward J. Hoffman, Steven M. Larson, Heinrich R. Schelbert, Markus Schwaiger, Henry N. Wagner, Alfred P. Wolf, Paul K. Strudler, Theodore C. Doege
Journal: JAMA (1988)

This report describes the current and potential uses of positron emission tomography in clinical medicine and research related to oncology. Assessment will be possible of metabolism and physiology of tumors and their effects on adjacent tissues. Specific probes are likely to be developed for target sites on tumors, including monoclonal antibodies and specific growth factors that recognize tumors. To date, most oncological applications of positron emission tomography tracers have been qualitative; in the future, quantitative metabolic measurements should aid in the evaluation of tumor biology and response to treatment.
Cancer care during the last phase of life.
Journal: Journal of Clinical Oncology (1998)

EXECUTIVE SUMMARY: The American Society of Clinical Oncology (ASCO) believes that it is the oncologists' responsibility to care for their patients in a continuum that extends from the moment of diagnosis throughout the course of the illness. In addition to appropriate anticancer treatment, this includes symptom control and psychosocial support during all phases of care, including those during the last phase of life. In an effort to assure that all patients and their families have access to optimal care at the end of life, ASCO firmly believes it is essential to emphasize a humane system of cancer care based on the following principles: Cancer care is centered around the longstanding and continuous relationship between the primary oncologist or other physician with training and interest in end-of-life care and the patient; Cancer care is responsive to the patient's wishes and to the parents' wishes if the patient is a child; Cancer care is based on truthful, sensitive, empathic communication with the patient, and in the case of pediatric patients, that care is both family centered as well as child focused; and Cancer care optimizes quality of life throughout the course of an illness through meticulous attention to the myriad physical, spiritual, and psychosocial needs of the patient and family. To reach these goals, ASCO has identified numerous obstacles that hinder delivery of high-quality end-of-life care and offers recommendations for improvements. ASCO is committed to informing its membership and the public about the significant barriers to optimal care at the end of life, and advocating legislative and regulatory changes that will eliminate these barriers.
Di(2-ethylhexyl) adipate
Journal: Environmental Health Perspectives (1982)

Di(2-ethylhexyl) Adipate: Condensation of the Carcinogenesis Bioassay Technical Report* Di(2-ethylhexyl) adipate [bis(2-ethylhexyl) adipate, DEHA, octyl adipate, dioctyl adipate, DOA, CAS No. 103-23-1], a plasticizer added to vinyl plastics to give low temperature flexibility, is dispersed (not bound) in the polymer chain matrix.Approved by the U.S. Food and Drug Administration for use in plastics that may contact nonfatty, nonalcoholic foods (not to exceed 24% by weight of the plastic polymer), DEHA has wide use in vinyl packaging ifim for refrigerated and frozen food products.Other products containing DEHA include electric wire insulation, garden hoses, vinyl coated fabrics for automotive and upholstery use, synthetic rub- ber, base oils for hydraulic fluids, and, among others, polyvinyl tubing for hemodialysis.For these uses 44 million pounds were produced in 1978.DEHA was selected as a representative of the adipate class of plasticizers, because it is structur- ally related to di(2-ethylhexyl) phthalate, because human exposure is widespread, and because no carcinogenesis studies had been done.
Biliary tract
Authors: D Alextander, P Mdan, R Aha1mers, D Alexander, P Madan, S Curley, J Switala, G Favero, F Di, A Caroli, A Volpi, A Puglisi, P Scalon, T Meggiato, R Naccarato
Journal: Gut (1992)

Infection is believed to be important to the development of the 'septic' syndrome which complicates severe pancreatitis, and an indication for operative intervention.In order to evaluate the role of infection in the pathogenesis of severe acute pancreatitis a prospective study was carried out in 23 patients with pancreatic necrosis who underwent percutaneous aspiration at the time of either computed tomography (CT) or ultrasound examination.Patients were initially treated conservatively, (including 'pig-tail'drainage of the pancreatic collection) and operative treatment using debridement and external drainage was used if the patient's condition deteriorated.Twelve patients were infected and 11 sterile.Four patients with sterile necrosis died, three after surgery had been performed, whilst there was one death (post-operative) in the group with infected necrosis.There was no significant difference in the APACHE II scores between the 2 groups (median value of 5.5 for the infected group v 6 for the sterile group).These results suggest that the presence of infection in an area of pancreatic necrosis cannot be determined clinically, and that infection is not an important determinant of outcome if percutaneous drainage is used in it's management.Infection was not an indication for operative intervention.W74
Preservation and restoration of joint function in patients with severe burns
Authors: E. B. Evans
Journal: JAMA (1968)

In patients with severe burns joint function may be compromised by para-articular ossification, septic arthritis, dislocation, or soft-tissue contracture. Ectopic bone forming as a sequel to burns, once excised, does not tend to recur. Septic arthritis may be dealt with as in patients without burns; but the signs and symptoms of joint sepsis are masked in burns, and the common result is ankylosis. Dislocations of otherwise intact joints may be dealt with in standard fashion; those secondary to joint destruction cannot be reduced. Whereas ectopic bone, septic arthritis, and dislocation, combined, occur in no more than 5% of severely burned patients, soft-tissue contracture occurs in almost all patients with extremity burns. Contracture is prevented by positioning, physical therapy, and splinting; it is corrected with skeletal traction or suspension alone, or in conjunction with surgery, or with surgery alone.
Human Heart Isolated and Perfused
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE CAUSE OF INFLUENZA
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MISCELLANY
Journal: JAMA (1953)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Whatever Else
Authors: Jack Coulehan
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Obeticholic acid improves hepatic fibroinflammation as assessed by multiparametric magnetic resonance imaging: interim results of the regenerate trial
Authors: Rohit Loomba, Quentin Anstee, Stephen Harrison, Arun Sanyal, Vlad Ratziu, Zobair Younossi, Zachary Goodman, Pierre Bedossa, Rajarshi Banerjee, Michael Stenkilsson, Reshma Shringarpure, Luna Zaru, Aditya Venugopal, Leigh MacConell, Mary Rinella
Journal: Journal of Hepatology (2020)
Massachusetts Medical Society
Authors: J. P. Fahy
Journal: New England Journal of Medicine (1957)

INDUSTRIAL-ACCIDENT FEESThe Industrial Accident Board, acting pursuant to the authority contained in General Laws, Chapter 152, Section 3, as amended, voted on September 17, 1956, to establish the following fees for physicians for medical services: house visits, $5.00; first office visit, $5.00; and subsequent office visits, $4.00.Under certain circumstances higher fees may be paid for special services.A number of inquiries have been made concerning purported increases in fees for surgical procedures. As yet, none have been authorized. A committee of the Society has met with the chairman of the Industrial Accident Board, and the Society now . . .
Isolation of oval cells from Long-Evans Cinnamon rats and their transformation into hepatocytes in vivo in the rat liver
Authors: O Yasui
Journal: Hepatology (1997)

Oval cells function as compensatory cells in severe liver injury and are thought to be equivalent to liver stem/progenitor cells. We isolated oval cells from the liver of Long-Evans Cinnamon (LEC) rats by isopyknic centrifugation in a Percoll gradient. The cells were gamma-glutamyl transpeptidase (GGTP)-positive, alpha-fetoprotein-positive, and cytokeratin (CK) 18- and CK 19-positive, but albumin-negative in the cells. When oval cells were transplanted to the liver, they were transformed into hepatocytes. To evaluate albumin biosynthesis, we transplanted oval cells into the liver of Nagase analbuminemic and LEC double mutant rats. The albumin level in the serum of transplanted rats was increased and maintained for up to 10 weeks. These results indicated that the oval cells isolated from LEC rats can differentiate into hepatocytes in vivo. (Hepatology 1997 Feb;25(2):329-34)