tbuckley/cabot-search huggingface dataset:
Abstract 18601: Impact of Right and Left Atrial Remodeling on Outcomes From Atrial Fibrillation Rotor Ablation
Authors: Amir Schricker, Tina Baykaner, Junaid Zaman, Gautam Lalani, Kenneth Hopper, Antonio Moyeda, David E Krummen, Sanjiv M Narayan
Journal: Circulation (2015)

Introduction: Targets for the ablation of atrial fibrillation (AF) are debated. In particular, recent studies questioning fractionated electrograms and lines has increased focus on AF substrates of rotors and focal impulses. These AF sources are seen in both atria, but have unknown etiology. We hypothesized that differential remodeling between the right atrium (RA), whose structural changes are largely undefined, and left atrium (LA) influence the distribution of AF sources and the outcomes from AF source ablation. Methods: In 60 patients at AF ablation (62±10 years, 60% persistent, 5% long-standing persistent), we compared size differences between RA and LA to the number of sources in each chamber and outcomes from AF source-guide ablation. We studied if a 64-pole basket differentially fit the LA or RA, judged by deformation of its splines by the atria (fig. A, B) over multiple cardiac cycles on fluoroscopy. Ablation targeted sources in both atria and was followed by PVI, with follow-up per guidelines. Results: Using baskets in both atria, 205 sources (LA 138; RA 67) were identified and ablated. Notably, the same basket in each patient was dynamically deformed by RA in 51 (85%) of cases but in the LA in only 39 (65%), indicating greater LA remodeling. The number of AF sources was higher in the presence of basket deformation of RA (n=174) than LA (n=130). LA deformation correlated with LVEF (p=0.05). Freedom from AF at 1 year was reduced in patients with no basket deformation (i.e. dilation) in LA (p=0.07) or RA (p=0.06). Notably, single procedure AF freedom was substantially lower in patients with differential remodeling (deformation in only 1 chamber) of 84% vs. 60% (fig C). Conclusions: Structural atrial remodeling influences the number of electrical rotors and focal sources in each chamber. A mismatch between right and left atrial remodeling predicts lower success from rotor ablation. These data also provide novel clinical indices of effective basket positioning.
Diagnosis and Treatment of Brain Injuries with and without a Fracture of the Skull.
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Petit mal epilepsy. Results of a prolonged follow-up study of 117 patients
Authors: S. Livingston
Journal: JAMA (1965)

Since the advent of electroencephalography, it has been clearly demonstrated that all epileptic seizures of brief duration are not petit mal. It is important that the physician who cares for epileptic patients be cognizant of this fact, since the treatment and prognosis of petit mal epilepsy differ in most respects from that of other types of epilepsy. Petit mal epilepsy is primarily a disorder of childhood and seldom continues into adulthood. It is a comparatively rare type of epileptic spell: of 15,102 epileptic patients, only 364 (2.3%) had "true" petit mal epilepsy. It is a relatively benign disturbance and rarely causes demonstrable evidence of pathological cerebral changes, except in those patients who have frequent attacks of petit mal status. Since patients with petit mal epilepsy are prone to develop major seizures, concurrent administration of petit mal and major motor anticonvulsants (combined therapy) is recommended.
Cytomegalovirus infection.
Authors: P Ljungman, H Einsele
Journal: BMJ (1971)

Cytomegalovirus infection was for many years one of the major complications of allogeneic bone marrow transplantation. During the past few years there have been major advances in the management of patients at risk for cytomegalovirus disease, and there are now several strategies that can be used. Antiviral prophylaxis has improved considerably and there are now three antiviral agents that can be used. Immunoprophylaxis by infusion of specific cytotoxic T cells is now feasible. The development of techniques for rapid diagnosis of cytomegalovirus infection including the antigenemia assay and the polymerase chain reaction for detection of cytomegalovirus DNA have made the use of preemptive therapy an attractive strategy. The outcome of therapy of cytomegalovirus pneumonia is still poor, with a survival of only approximately 50%, despite use of the combination of ganciclovir and high-dose immunoglobulin.
At start of second smallpox-free decade, debate continues about keeping virus
Authors: K. Sternberg
Journal: JAMA (1988)

THE LAST CASE of smallpox was reported ten years ago, but the debate continues whether to maintain samples of the live virus. A year after the last-known case was reported, the World Health Organization (WHO)—in 1979—officially declared the disease eradicated. Several research facilities around the world then stored frozen samples for possible further viral studies. Today, only two sites continue to store the virus—the Centers for Disease Control (CDC), Atlanta, and the Research Institute of Viral Preparations, Moscow. <h3>Only Two Places?</h3> In fact, since it is "very unlikely that any viable smallpox virus exists anywhere else in the world," according to Kenneth Herrmann, MD, acting director of the CDC's Division of Viral Diseases, the question increasingly asked is: Why store this virus at all? Looking at the most unpleasant possibility, Australia's Frank Fenner, MD, former chair of the Global Commission for the Certification of Smallpox Eradication, writes in the WHO's
Problems with incentives
Authors: J. S. Todd
Journal: JAMA (1990)

Few would argue that our current methods of financing and delivering health care are without severe problems and inadequacies. So much so that many (more out of despair than conviction) would scrap the whole model for the unknown consequences of what is perceived to be a more equitable and perhaps less expensive system. Most of those who espouse this concept argue that the only way to gain control of rising expenditures and the uninsured population is by converting to a single-source funding mechanism. This, they believe, will restore equity, equalize incentives, and guarantee health care to all without the interposition of personal financial considerations. Throughout much of these discussions, the issue of incentives and how to manipulate them assumes increasing importance. Some argue that the provision of adequate payment under any system will assure that care, sometimes of marginal value, will be given, but that at least the financial barrier
BOOK REVIEWS
Authors: F. J. BRESCIA
Journal: JNCI Journal of the National Cancer Institute (1994)

BOOK REVIEWS Get access The Medical Care of Terminally III Patients Robert E. Enck . Baltimore : Johns Hopkins Univ. Press , 1994 . 202 pp., illus. $28.95. ISBN 0-8018-4763-X FRANK J. BRESCIA, M.D. FRANK J. BRESCIA, M.D. Calvary Hospital1740 Eastchester Rd. Bronx, NY 10461 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 86, Issue 13, 6 July 1994, Pages 1022–1023, https://doi.org/10.1093/jnci/86.13.1022-a Published: 06 July 1994
Reply
Authors: P Vincent, F Gottrand, D Turck
Journal: Gut (1995)

<h3>Abstract</h3> We have demonstrated that adaptive responses to BET inhibitors induce a therapeutic vulnerability to the combination of BET and MCL1 inhibitors in breast cancer. Our generalizable strategy for identification of adaptive responses and therapeutic vulnerabilities integrates our novel network analysis method, termed Target Score, with genomics and mechanistic perturbation biology studies. In drug resistant cells, adaptive responses to BET inhibitors involve upregulation of fatty acid metabolism coupled to changes in membrane fluidity, cell adhesion and motility, EGFR/HER2 pathway activation, and subsequent accumulation of MCL1 that drives apoptosis evasion. The combined inhibition of MCL1 and BET proteins is highly synergistic in diverse breast cancer models. MCL1 inhibition was found to be most effective, either as a single agent or in combination in tumors with MCL1 chromosomal amplifications, a frequent driver aberration in breast cancer. In conclusion, we have discovered a mechanism of resistance to BET inhibition and an anti-resistance combination therapy that can increase the therapeutic benefit for a significant fraction of breast cancer patients.
Studies to compare treatment regimens: the randomized clinical trial and alternative strategies
Authors: S. S. Ellenberg
Journal: JAMA (1981)

The randomized clinical trial (RCT) has become generally accepted as the most valid study mechanism for assessment of therapeutic regimens. Because random allocation of treatment guards against any systematic association of treatment assignment with prognosis, differences in outcome that are observed among treatment groups in an RCT will tend to result from treatment effects and not from inherent differences among the groups. Studies in which treatment allocation is by design associated with patient characteristics—eg, where treatment is selected individually for each patient, or according to the clinic to which the patient comes, or according to the time period in which the patient is treated—are vulnerable to selection bias. This bias is incurred whenever patients with differing prognoses have differing probabilities of receiving the treatments to be compared. In an article in this issue (p 2455), Horwitz and Feinstein explore the potential usefulness of another approach to the evaluation of therapeutic
Announcement Review Focus on Caveolae in Cardiovascular Signaling
Authors: Ingrid Fleming
Journal: Cardiovascular Research (2005)

A Review Focus on Caveolae in Cardiovascular Signaling is scheduled to appear in March, 2006.Caveolae, or "little caves", are approximately 50-100 nm in diameter and are found in many of the cells within the cardiovascular system (endothelial cells, smooth muscle cells, macrophages, cardiac myocytes, and fibroblasts).Over the last few years it has become clear that caveolae are involved in the trafficking of proteins and contain a large variety of signal transduction molecules, a phenomenon which means that these organelles become signaling "hotspots" following cell activation.Both the structure and function of caveolae are dependent on caveolins, and data obtained using caveolin knockout animals have highlighted the role played by these structural proteins in cardiovascular physiology and pathophysiology.Preliminary topics of invited review articles related to caveolae include:
HAWAIIAN FEVER.
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
FAVUS GENERALISATUS.
Authors: A. DOSTROVSKY, F. SAGHER, F. RAUBITSCHEK
Journal: British Journal of Dermatology (1957)

Journal Article FAVUS GENERALISATUS. Get access A. DOSTROVSKY, A. DOSTROVSKY Department of Dermatology and Venereology (Dr. F. Sagher. Director), Hebrew University‐Hadassah Medical School, Jerusalem, Israel Search for other works by this author on: Oxford Academic Google Scholar F. SAGHER, F. SAGHER Department of Dermatology and Venereology (Dr. F. Sagher. Director), Hebrew University‐Hadassah Medical School, Jerusalem, Israel Search for other works by this author on: Oxford Academic Google Scholar F. RAUBITSCHEK F. RAUBITSCHEK Department of Dermatology and Venereology (Dr. F. Sagher. Director), Hebrew University‐Hadassah Medical School, Jerusalem, Israel Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 69, Issue 10, 1 October 1957, Pages 358–362, https://doi.org/10.1111/j.1365-2133.1957.tb13771.x Published: 01 October 1957
Abstract 19270: Heart Failure Incidence is Elevated in Adults With Simple Congenital Heart Defects Compared With the General Population: A Cohort Study
Authors: Morten Olsen, Dan E Høfsten, Nicolas L Madsen, Henning B Laursen, Søren P Johnsen, Jørgen Videbæk
Journal: Circulation (2015)

Heart failure (HF) is a major cause of morbidity and mortality in adults with congenital heart defects (CHD). However, few data exist on the long-term prognosis of simple CHD. We aimed to estimate the incidence of HF and use of HF drugs in individuals with simple CHD compared with the general population. Methods: We identified a nationwide population-based simple CHD cohort, defined by isolated and uncomplicated secundum atrial septal defect (ASD), persistent ductus arteriosus (PDA), ventricular septal defect (VSD) judged to be either muscular or with normal pulmonary flow resistance, or mild pulmonary stenosis (PS) verified by catheterization. Subjects were born and diagnosed from 1963 through 1973 in Denmark. We included patients with no childhood co-morbidity who were alive at 32 years of age (this age was determined by the establishment of a nationwide prescription register in 1995). For each CHD subject, we identified 10 control individuals from the general population using the Danish Civil Registration System, matched by sex and birth year. A unique personal identifier used in all Danish public registries enabled virtually complete follow-up for migration, death, use of HF drugs, or HF diagnoses as identified in a hospital discharge registry covering all Danish hospitals since 1977. Specific indications for drug use were unknown (could be e.g. hypertension). We computed cumulative incidence of first diagnosis of HF and first filling of a HF drug prescription, for CHD subjects and controls, and the corresponding hazard ratios (HR). Results: We identified 802 CHD subjects (ASD, n=115; VSD, n=437; PS, n=75; PDA, n=175) and 7,947 controls, 43% male. Cumulative incidence for CHD subjects by age 45 years of HF drug use was 22% (16% for controls), whereas it was 3% (0.4% for controls) for a HF hospital diagnosis. The corresponding HRs comparing CHD subjects with controls were 1.4(95% CI:1.2-1.6) and 6.9(95% CI:4.0-12). Conclusion: Adults with simple CHDs were at increased risk of HF. The data on HF drug use should be interpreted with caution as other cardiovascular conditions were likely the indications for many of the prescriptions. However; further studies on the effectiveness of medical follow-up programs for patients with simple CHDs appear warranted.
The Two Faces of Pathogenic Escherichia coli
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract SY15-03: Coding and noncoding genome for blood biopsy
Authors: Daniel F. Hayes, Catherine Alix-Panabières, George A. Calin
Journal: Cancer Research (2019)

Abstract The development of effective diagnostic and prognostic biomarkers is crucial for early detection of cancer, prediction of clinical outcome, detection and monitoring minimal residual disease, and identification of patients who can benefit from therapy. Furthermore, they can provide important information of biological characteristics of tumor. Liquid biopsy, an alternative and non-invasive technique to surgical biopsy, enables the investigation of tumor markers in biological fluids, such as serum/plasma, urine, saliva, and pleural effusion. Increasing interest on liquid biopsy has grown over the past decade with particular focus on circulating non-coding RNAs (ncRNAs) and tumor-derived cell-free DNA (cfDNA) as cancer biomarkers. Owing to their high abundance and stability in biological fluids, circulating ncRNAs and tumor-derived cell-free DNA have potential utility to provide information on tumor biology (e.g.: EGFR and PIK3CA mutational status) which can help both diagnosis and prediction of effects of treatments, including standard treatment, targeted therapies, and immunotherapies. Recent advances in the field have highlighted the role of circulating ncRNAs in cell-to-cell communication. Particularly, ncRNAs can be transported through extracellular vesicle-mediated transfer to recipient cells, where they exert their functions of gene expression regulation, with implications for cancer progression and therapy resistance. This characteristic of circulating ncRNAs introduces an additional step in the information on tumor biology that can be obtained from liquid biopsy. Besides cancer, ncRNAs can also serve as biomarkers for microbial infection. Indeed, miRNAs originated from non-human genomes (xeno-miRNAs), such as viral miRNAs (Epstein-Barr virus, Kaposi sarcoma-associated herpesvirus), have been shown to be present in human body fluids. They can be used as biomarkers for diagnosis, prediction of clinical outcome, and the can also mediate cell-to-cell communication. Liquid biopsy has the potential to serve as additional tool to improve diagnosis, prognosis, prediction of treatment responses, and can provide information of biological characteristics of tumor. Citation Format: Daniel F. Hayes, Catherine Alix-Panabières, George A. Calin. Coding and noncoding genome for blood biopsy [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr SY15-03.
Costimulating aberrant T cell responses by B7-H1 autoantibodies in rheumatoid arthritis
Authors: Haidong Dong, Scott E. Strome, Eric L. Matteson, Kevin G. Moder, Dallas B. Flies, Gefeng Zhu, Hideto Tamura, Colin L.W. Driscoll, Lieping Chen
Journal: Journal of Clinical Investigation (2003)

A pathogenic hallmark of rheumatoid arthritis (RA) is persistent activation of self-reactive CD4+ T cells. The cause of this aberrant activity remains elusive. We report here detection of autoantibodies against B7-H1, a recently described member of the B7 family, in 29% of patients with RA versus 4% of healthy donors. High-level expression of cell surface B7-H1 are found on activated human CD4+, CD8+, and CD45RO+ T cells. Immobilized autoantibodies to B7-H1 are capable of costimulating the proliferation of CD4+ T cells in vitro, and the presence of these autoantibodies correlates with active disease status. Using immobilized B7-H1 mAb's and programmed death 1Ig, we demonstrate that engagement of B7-H1 on CD4+ T cells costimulates proliferation and secretion of IL-10, and subsequently leads to programmed cell death, accompanied with upregulated expression of TNF-related apoptosis–inducing ligand and activation of caspase-3. Taken together with our previous findings, these data indicate a bidirectional signaling role of B7-H1 in T cell costimulation and apoptosis and implicate B7-H1 autoantibodies as contributing to the progression of RA by inducing aberrant T cell responses.
Warm up
Journal: British Journal of Sports Medicine (2000)

Warm upHappy Birthday to a legend.One giant salutes another as Jerry Morris, the doyen of British exercise epidemiology, celebrates his 90th birthday and Ralph PaVenbarger reflects on his lifetime contribution (page 217).From opposite sides of the world they will be linked forever by their dedication to a common theme and research excellence.Two masters in sports medicine.True pioneers.New frontiers in sport and exercise medicine will be at molecular level as we struggle to solve some of the mysteries of cellular metabolism.We are still learning why moderate exercise can improve immune function, yet excessive exercise may be harmful (page 161).The relationship between exercise, cancer, and the body's natural defence mechanism is closely linked too, and there is some evidence that physical activity may enhance that protective eVect.Exercise may even have a place in cancer treatment, but cancer is more associated with suVering than with sport, so that the cancer athlete takes us completely by surprise when Dimeo reminds us of last year's sporting heroes (page 160).Cellular manipulation is on July 9,