tbuckley/cabot-search huggingface dataset:
Diagnostic Problems of Esophageal Cancer
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Management of endocrine ophthalmopathy.
Journal: BMJ (1968)

PointersAnticoagulants and Infarction: Results of trial in Norway indicate that women benefit as much as men from long-term anticoagulant therapy after myocardial infarction (p.571).Dockyard Exposure to Asbestos: Pleural and pulmonary fibrosis and pleural mesothelioma were associated with long-term exposure, even if exposure was intermittent.So far 10 cases of mesothelioma had occurred (p.574).Dangers of Chloroquine: Simple scheme for rendering patients ophthalmologically safe; drug's therapeutic value considered to outweigh minor side-effects (p.579).Nephrotic Syndrome: Two cases associated with heart disease responded to prednisone.(p.584).Anastomotic Leak : Neostigmine given to reverse curarization may cause leaking at ileorectal anastomoses.The mechanism may be increased muscular activity of gut or vasoconstriction near suture line (p.587).Arteritis of Aorta: Immunoglobulin levels raised in sera from 21 patients, but rheumatoid and antinuclear factor and antibodies to aorta, liver, and thyroid were not raised (p.589).Vitamin B Deficiency: Rapid detection tech- nique suitable for routine laboratories investigat- ing debilitated patients (p.591).Asthma: Disodium cromoglycate inhibited usual post-exercise fall in F.E.V.1 and may be reason for subjective improvement given by this drug (p.593).Hyperpyrexia during Anaesthesia: Malignant hyperpyrexia occurred in pigs anaesthetized with nitrous oxide and halothane in the absence of suxamethonium (p. 594).Absence of Lumbar Spine: Case report emphasizes importance of early treatment (p. 595).Drowning: Varieties discussed by ).Today's Drugs: Urinary tract infection and its management (p.600).Patients and X-rays: Survey indicates that better information and more reassurance are re- quired (p.607). Improving Prescribing: System to.reduce dan- gers of drug prescribing and administration in hospital (p.609).
Contents page
Authors: Gu ¨nther Knoblich, Natalie Sebanz, Tim Andrews, Dale Purves, Robert Seyfarth, Dorothy Cheney, Thore Bergman, Bernard Baars, Steven Laureys, Cathy Price, Guillaume Thierry, Tim Griffiths, David Buller, Timothy O'donnell, Marc Hauser, W Fitch, Rene ´marois, Jason Trendsin, Julian Ogilvie, Katie Forsythe, Manager Moulton
Journal: Trends in Cognitive Sciences (2005)
PWE-076 Absence Of Gut Microbiota Reduces Lipopolysaccharide-induced Epithelial Cell Shedding In The Small Intestine
Authors: K Hughes, C Alcon-Giner, M Lawson, K McCoy, A Macpherson, L Hall, A Watson
Journal: Gut (2014)

<h3>Introduction</h3> Cell shedding, the process by which intestinal epithelial cells (IECs) are extruded from the small intestinal (SI) villus, is known to be elevated in patients with inflammatory bowel disease (IBD) and is correlated with disease relapse. Importantly, the epithelial barrier is in contact with intestinal bacterial communities (i.e. the microbiota) and studies have correlated disturbances in the microbiota with IBD. Thus, we hypothesised that cell shedding may be modulated by the microbiota. <h3>Methods</h3> Specific pathogen free (SPF) and germ-free (GF) C57BL/6 mice, including GF mice reconstituted for 4 weeks with altered Schaedler flora (ASF), stable Defined Moderately Diverse Microbiota (sDMDMm2), or SPF faeces, were given 10mg/kg Lipopolysaccharide (LPS) intraperitioneally to induce SI cell shedding. Animals were euthanized 1.5 h post-LPS. Tumour Necrosis Factor-α (TNF-α) and cleaved caspase 3 (CC3) ELISA were performed on whole SI homogenates. Immunohistochemistry (IHC) for CC3 was performed on formalin fixed paraffin embedded SI tissue and CC3 +ve villus IECs quantified using WinCrypts and Score programs. Statistics were performed using ANOVA with Dunnett’s post-test. <h3>Results</h3> ELISA analysis showed significant decreases in CC3 in GF vs SPF mice following LPS administration (2.6-fold+/-0.3, p &lt; 0.01). Decreased levels of TNF-α (GF, 189+/-56 pg/ml vs SPF, 548+/-66; p &lt; 0.01), showed a potential mechanistic basis for this change. Reconstitution with ASF or sDMDMm2 failed to restore levels of shedding observed in LPS treated SPF mice. CC3 ELISA (ASF, 1.1-fold+/-0.3, ns; sDMDMm2, 1.0-fold+/-0.1, ns); TNF-α ELISA (ASF, 311+/-48 pg/ml, p &gt; 0.05; sDMDMm2; 231+/-77 pg/ml, p &lt; 0.05). IHC and count analysis confirmed that LPS treated GF, ASF or sDMDMm2 mice were unable to mount a normal cell shedding response vs LPS treated SPF mice: Mean% CC3 positive IECs along the length of the villus of 4.3%+/-1.2, 0.6%+/-0.3, 0.5%+/-0.2 vs 7.9%+/-1.1, respectively (all p &lt; 0.01). Importantly, when LPS was delivered to GF mice reconstituted with SPF faeces, similar rates of shedding to LPS treated SPF mice were observed and TNF-α production was restored. <h3>Conclusion</h3> GF mice are largely refractory to LPS induced cell shedding, when compared to SPF or fully reconstituted GF mice, via modulation of the pro-inflammatory cytokine TNF-α. These data strongly implicate the intestinal microbiota in cell shedding and may help to shape microbiota-based treatment of IBD patients. <h3>Disclosure of Interest</h3> None Declared.
BEDBUGS AND DISEASE POSSIBILITIES.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Continuing medical education in the Union of the Soviet Socialist Republics. Philosophy and approaches
Authors: F. Vartanian
Journal: JAMA (1987)

CONTINUING medical education (CME) in the Union of the Soviet Socialist Republics (USSR) is comprehensive and systematic, perhaps uniquely so. This article offers a very broad review of the philosophy and approaches that formed the basis of the national health care services, its main operating principles, its implementation strategies, and its educational planning and effectiveness. <h3>Inception</h3> The first successful effort to establish a prototype of CME was the institute for postgraduate training of physicians in Leningrad (formerly St Petersburg), founded some 100 years ago. However, it was not until the Soviet government came into power that government legislation on CME was introduced. The Special Act on the Scientific Mission of Physicians of 1927 ensured that physicians undergoing postgraduate training continue receiving their salaries for the entire period of training. In 1934, the Government Act on Medical Training became the first state decree to establish a uniform system of postgraduate medical
Poster Session 3: Experimental Studies in Cirrhosis and Portal HTN; Health Economics and Cost Effectiveness of Viral Hepatitis
Authors: Hitoshi Maruyama, Takayuki Kondo, Tadashi Sekimoto, Soichiro Kiyono, Osamu Yokosuka, Francesco De Chiara, Rajiv Jalan, Vairappan Balasubramaniyan, Fausto Andreola, Massimo Malago, Massimo Pinzani, Rajeshwar Mookerjee, Krista Rombouts, Dinesh Tripathi, Erica Lafoz, Hector Garcia-Caldero, Juan Car- Los Garcia-Pagan, Jaime Bosch, Marcus Hollenbach, Antje Thonig, Sabine Pohl, Maurice Michel, Cristina Ripoll, Robin Greinert, Patrick Michl, Alexander Zip- Prich;, Amar Dhillon, Julie Parkes, William Rosenberg, Brian Hogan, Ioanna Parisi, David Patch, Dominic Yu, Andrew Hall, Ankur Srivastava, Paul Trem- Bling, Sudeep Tanwar, Tim Meyer, James O'beirne, Vikrant Rachakonda, Erin Kershaw, Jaideep Behari, Chikage Nakano, Takashi Nishimura, Tomoko Aoki, Kyohei Kishino, Yoshihiro Shimono, Kunihiro Hasegawa, Ryo Takata, Kazunori You, Akio Ishii, Tomoyuki Takashima, Yoshiyuki Sakai, Nobuhiro Aizawa, Naoto Ikeda, Hiroki Nishikawa, Yoshinori Iwata, Hirayuki Enomoto, Shuhei Nishiguchi, Hiroko Iijima, Zobair Younossi, Haesuk Park, Douglas Dieterich, Sammy Saab, Aijaz Ahmed, Stuart Gordon
Journal: Hepatology (2015)
Resistance to Infection with Virulent Tubercle Bacilli in Mice Immunized with Viable Mycobacterium Balnei and Unclassified Mycobacteria Administered Aerogenically
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Error in Abstract
Authors: Laura Iglesias-Girard, Simon Roy, Hugo Chapdelaine, Delphine Désy, Danielle Bouffard, Deana Funaro
Journal: JAMA Dermatology (2020)

Megan Lam, BSc; Jie Wei Zhu, BHSc; Talha Maqbool, MD; Gaelen Adam, MLIS, MPH; Mina Tadrous, PharmD, PhD; Paula Rochon, MD, MPH; Aaron M. Drucker, MD, ScM
Clinical Manifestations and Therapy of Acute Lead Intoxication Due to the Ingestion of Illicitly Distilled Alcohol.
Authors: J. C. Crutcher
Journal: Annals of Internal Medicine (1962)

s1 April 1962Clinical Manifestations and Therapy of Acute Lead Intoxication Due to the Ingestion of Illicitly Distilled Alcohol.J. C. Crutcher, M.D. (Assoc.)J. C. Crutcher, M.D. (Assoc.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-56-4-673_4 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptEarlier work by this author suggested that "moonshine" may be a source of toxic amounts of lead, and the epidemiologic aspects of this observation have been published. The current report concerns the clinical manifestations, differential diagnosis, and result of therapy with calcium disodium edathamil in 40 patients with lead intoxication due to ingestion of illicitly manufactured whisky.The gastrointestinal tract was the site of the majority of symptoms, which ranged from simple anorexia and nausea to severe obstipation, requiring surgical exploration for suspected colon obstruction. In other patients, the abdominal pain suggested acute surgical emergencies. Later experience has prevented this... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Atlanta, Ga. (CS) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1962Volume 56, Issue 4Page: 673-674KeywordsAbdominal painAlcoholismCalciumColonEpidemiologyGastrointestinal tractIngestionIntoxicationNausea Issue Published: 1 April 1962 PDF DownloadLoading ...
Will heroin eventually see the light of day for treating chronic pain?
Journal: JAMA (1978)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pancreatic pseudocysts. A medical evaluation
Authors: C. M. Caravati
Journal: JAMA (1966)

Pancreatic pseudocysts often present as a multifaceted clinical picture which is frequently misinterpreted by the clinician because of lack of appreciation of many of the clinical signs and laboratory findings. The purpose of this report is to review our experience with 42 cases of pancreatic pseudocysts and to emphasize major points of diagnostic importance. The cases reviewed include 19 at three metropolitan Richmond, Va, hospitals (Richmond Memorial, Johnston-Willis, and the Medical College of Virginia) and 23 at the McGuire Veterans Hospital seen from 1950 through 1964. Diagnosis was confirmed by surgery in 35 cases, by autopsy in 1, and in 6 cases the clinical features were so classical that the diagnosis of pseudocyst seems practically unequivocal. <h3>Definition</h3> Pseudocysts of the pancreas are so designated because they do not contain an epithelial lining and therefore are not true cysts. Pancreatic ductal epithelium does not migrate over the surface of these "cysts";
Diseases of the Colon and Rectum, Philadelphia
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE EFFECTS OF SPASM IN SCLEROTIC ARTERIES.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hepatitis A virus seroprevalence in the United Arab Emirates . Hepatology Unit, Beaumont Hospital, Sharjah Medical Area*, Zayed Military Hospital**, Abu Dahbi, UAE and the Department of Medical Microbiology, University College Dublin***, Ireland
Journal: Hepatology (1995)

During six days in November, 1987, 611 pupils (age range 7-19 years) and 39 adults (23-57) at a school complex in southern Finland had diarrhoea due to Escherichia coli 0111:B4. Diarrhoea developed in 137 other household members during the two weeks after the school outbreak. The source of the organism remains unknown. The outbreak strains, when incubated at 22°C or exposed to ampicillin, lost the lipopolysaccharide O antigen and began to react with antisera against Salmonella typhi Vi antigen. The Vi antigen-like reactivity increased the adherence of the organisms to Hep-2 cells. These results indicate that E coli 0111:B4, and possibly other enteropathogenic E coli strains, should be considered in the diagnosis of all diarrhoea cases and not only in infantile diarrhoea. Expression of Vi antigen in E coli may play a part in virulence by enhancing adherence to the intestinal epithelium.
Janus Kinase-2 Inhibition Induces Durable Tolerance to Alloantigen by Dendritic Cell-Stimulated Human T Cells, Yet Preserves Immunity to Recall Antigen
Authors: Brian C. Betts, Omar Abdel-Wahab, Shane A Curran, Erin T St. Angelo, Priya Koppikar, Glenn Heller, Ross L Levine, James W Young
Journal: Blood (2011)
Trends in Chlorinated Hydrocarbon Levels in Hudson River Basin Sediments
Authors: Richard F. Bopp, Steven N. Chillrud, Edward L. Shuster, H. James Simpson, Frank D. Estabrooks
Journal: Environmental Health Perspectives (1998)

Analyses of sections from dated sediment cores were used to establish geographic distributions and temporal trends of chlorinated hydrocarbon contaminant levels in sediments from natural waters of the Hudson River basin.Radiometric dating was based primarily on the depth distribution of 137Cs in the cores and on the occurrence of detectable levels of 7Be in surface sediment samples.Eighteen sampling sites included several along the main stem of the Hudson, its major tributaries, and components of the New York/New Jersey (NY/NJ) harbor complex.Drinking-water reservoirs were sampled to place upper limits on atmospheric inputs.Core sections were analyzed for polychlorinated biphenyls (PCBs), 1,1,1-trichloro-2,2-bis(p- chlorophenyl)ethane (DDT)-derived compounds, chlordane, and dioxins.Sediment concentrations of most contaminants at most sites have decreased significantly since the mid-1 960s.The data provide a basinwide perspective on major point-source inputs of PCBs to the upper Hudson River and of 2,3,7,8-tetrachlorodibenzo-p-dioxin and DDT to the lower Passaic River.Evidence was found for significant but poorly characterized sources of PCBs and chlordane to the western NY/NJ harbor, and of highly chlorinated dioxins to the upstream sites on the main stem of the Hudson.The results indicate that analysis of dated sediment samples is a most effective and efficient monitoring tool for the study of large-scale geographic and temporal trends in levels of particle-associated contaminants.
The promiscuous receptor: a case for the guardian enzyme
Authors: K. T. Weber
Journal: Cardiovascular Research (1995)

Journal Article The promiscuous receptor: a case for the guardian enzyme Get access Karl T. Weber Karl T. Weber Series Editor Karl T. Weber. University of Missouri-Columbia, Division of Cardiology, Room MA432 Medical Sciences Building, Columbia, MO 65212, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 30, Issue 2, August 1995, Page 176, https://doi.org/10.1016/S0008-6363(95)00032-1 Published: 01 August 1995
IBD and colorectal
Authors: A Douds, M Baig, C Page, M Yamada, J Goldman, Mckenna St, Mj Smally, M Selden, Hjf Hodgson
Journal: Gut (1996)

Asymptomatic left ventricular enlargement (LVE) occws in up to 30% of patients with alcoholic liver disease (ALD).The presence of IgG antibodies to cardiac acetaldehyde adducts in alcoholics suggests that immumological mecnisms may play a role in the pathogene ss of LVE.We postulate that other antigens such as cardiac myosin may also be important in the development ofLVE.Aims Our first aim was to deterine if cardiac specific anti-aupha myosin antibodies are present in the sera of ALD patients.Secondly we investigated if these antibodies are associated with edocardiographic and sigal average electrocrographic (SAECG) ab e Methods Anti IgG alpha-myosin antibodies were assayed in: 51 consecutive ALD patients attending a liver clinic (age 52 + 9.9, 36 males) in 92 patiets with ischaemic heart disease (age 56+7.6, 70males), and in 203 normals (age 45+16, 100 males) using an ELISA.Patients with ALD also had 2D echocardiogaphy and an SAECG.Results Anti-IgG myosin antibodies were present in 9/51 (18%) patients with ALD (p<0.0001,x2), 4/92 (4%) patie=t with ischaemic heart disease (p=0.44)compared to 4/203 (2%) normask Myosin antibodies were significantly more common in ALD (P'0.02)than ischaemic heart disease patients.LVE was detected in 25% of patients with ALD and the SAECG was abnormal in 17%.Anti myosin antibody positivity/ titrs did not correlate with LVE or SAECG abnormalies in ALD patients.Conclusion Myosin antibodies are significantly increased in patients with ALD.They are not common in those patients with established ECHO or SAECG abnormakites suggesting that they do not occur simply as a consequence ofmyocardial damage.Myosin antibodies may be an early predictor of future development of LVE in patients with ALD.