tbuckley/cabot-search huggingface dataset:
Off-label drug use for cancer therapy and national health care priorities
Authors: C. G. Moertel
Journal: JAMA (1991)

A report from, of all places, the US General Accounting Office<sup>1</sup>appears in this issue of<i>JAMA</i>documenting that the majority of American oncologists are prescribing for cancer patients drug regimens that lack sufficient evidence of effectiveness for Food and Drug Administration approval. It further shows that most oncologists find that the Health Care Financing Administration and private insurance carriers are increasingly resistant to reimburse for such "off-label" drug uses. This problem, as well as a parallel issue of perceived overly rigid standards for approval of new anticancer drugs, has led organized groups of oncologists to plead for redress through their publications and through paid congressional lobbyists. These pleas have been supported by activist groups, as well as by officials of the National Cancer Institute, Bethesda, Md. Simplistically, one might ask: If there is no sound scientific evidence that a therapy is effective, ie, that
Revival of medical maintenance in the treatment of heroin dependence
Authors: D. R. Wesson
Journal: JAMA (1988)

In this issue ofThe JOURNAL, a group from Beth Israel Medical Center, including Vincent Dole, MD, and the late Marie Nyswander, MD, the discoverers of methadone maintenance, report their clinical experience in "medical maintenance" of former heroin addicts receiving methadone in which primary care physicians with experience in drug abuse treatment provided continuing methadone maintenance of socially rehabilitated, non—drug abusing patients in a medical office practice. The frequency of follow-up visits was determined by the treating physician on the basis of medical need and could be as infrequent as every 28 days. This is a major departure from the practice of methadone maintenance clinics, which usually require visits at least once weekly for monitoring and methadone dispensing. In addition, methadone tablets, rather than the liquid form of methadone mixed with juice that is usually dispensed by methadone maintenance clinics, were prescribed. The authors conclude that some socially rehabilitated methadone
Napkin psoriasis
Authors: R. P. Warin
Journal: British Journal of Dermatology (1966)

Journal Article Napkin psoriasis Get access R. P. Warin R. P. Warin Bristol Royal Hospital for Sick Children, St. Michael's Hill, Bristol, 2 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 78, Issue 11, 1 November 1966, Pages 613–614, https://doi.org/10.1111/j.1365-2133.1966.tb12158.x Published: 01 November 1966
A Comparison of Medication Side Effect Reports by Panic Disorder Patients With and Without Concomitant Cognitive Behavior Therapy
Authors: Sue Marcus
Journal: American Journal of Psychiatry (2007)

Objective: The authors assessed whether adding cognitive behavior therapy (CBT) to imipramine for patients with panic disorder decreased the severity of side effects and dropouts from side effects. Method: Data were analyzed for 172 panic disorder patients who were randomly assigned to receive imipramine alone, imipramine plus CBT, or placebo. Mixed-effects models were used to assess longitudinal differences among the treatment groups with respect to side effect burden and dropout rates during the acute, maintenance, and follow-up phases of treatment. Results: Patients treated with imipramine plus CBT experienced less severe fatigue/weakness, dry mouth, and sweating and had a lower rate of dropout due to side effects compared with those treated with imipramine only. Conclusions: The addition of CBT to medication treatment with imipramine was associated with less severe side effects and fewer dropouts due to perceived side effects than treatment with imipramine alone.
CHEST RADIOGRAPH FINDINGS IN PATIENTS WITH PULMONARY EMBOLISM; AN OBSERVATION FROM THE PIOPED STUDY
Authors: D. F. Worsley, A. Alavi, J. Arochick, T. Barrett, H. I. Palevsky
Journal: Clinical Nuclear Medicine (1993)

Worsley, D. F.; Alavi, A.; Arochick, J.; Barrett, T.; Palevsky, H. I. Author Information
Abstract 105: MTH1 promotes mitotic progression to avoid oxidative DNA damage in cancer cells
Authors: Kumar Sanjiv, Helge gad, Sean G. Rudd, Oliver Mortusewicz, Ailine Stolz, Nuno Amaral, Lars Brautigham, Linda Pudelko, Christina Kaldéren, Ann-Sofie Jemth, Ingrid Almlöf, Torkild Visnes, Niklas Schultz, Johan Boström, José Manuel Calderon Montano1, Anna Hagenkort, Petra Groth, Camilla Gokturk, Tobias Koolmeister, Prasad Wakchaure, Evert Homan, Mikael Altun, Cecilia Ström, Martin Scobie, Holger Bastians, Ulrika Warpman Berglund, Thomas Helleday
Journal: Cancer Research (2019)

Abstract MTH1 prevents incorporation of oxidized deoxynucleoside triphosphates (e.g., 8-oxodGTP) into DNA. Earlier we demonstrated that MTH1 inhibitors TH588 and TH1579 possesses anti-cancer activity in various tumour types, while other structurally distinct MTH1 inhibitors failed to kill cancer cells or elevate the levels of oxidized nucleotides in DNA. In our current study, we found a novel function of MTH1 in mitosis, as it plays an important role in correct spindle assembly in cancer cells and progression through mitosis, and furthermore, we demonstrate MTH1 binds tubulin in vivo. We also observed that structurally distinct MTH1 inhibitors display differential abilities to break the MTH1 tubulin interaction, and also demonstrate that TH588 and TH1579 can directly inhibit tubulin polymerisation in vitro. Consistent with our results, we establish that TH588 and TH1579 kill cancer cells by a mitosis-dependent mechanism and implicate reactive oxygen species (ROS) accumulation and incorporation of oxidised nucleotides into DNA in this process. Furthermore, we found that non-cytotoxic MTH1 inhibitors can become cytotoxic and increase incorporation of oxidised nucleotides into DNA when they are combined with sub-therapeutic concentrations of mitotic inhibitors. In conclusion, MTH1 inhibitors killing cancer cells have a unique and complex mechanism of action: (1) causing a mitotic arrest, induced by targeting MTH1 which is required for mitotic progression, but also through direct inhibition of microtubule polymerisation, in-turn leading to an increase in ROS and likely 8-oxodGTP and (2) MTH1-dependent 8-oxodGTPase inhibitory activity causing incorporation of damaged nucleotides into DNA to kill cancer cells. Citation Format: Kumar Sanjiv, Helge gad, Sean G. Rudd, Oliver Mortusewicz, Ailine Stolz, Nuno Amaral, Lars Brautigham, Linda Pudelko, Christina Kaldéren, Ann-Sofie Jemth, Ingrid Almlöf, Torkild Visnes, Niklas Schultz, Johan Boström, José Manuel Calderon Montano1, Anna Hagenkort, Petra Groth, Camilla Gokturk, Tobias Koolmeister, Prasad Wakchaure, Evert Homan, Mikael Altun, Cecilia Ström, Martin Scobie, Holger Bastians, Ulrika Warpman Berglund, Thomas Helleday. MTH1 promotes mitotic progression to avoid oxidative DNA damage in cancer cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 105.
Automatic Analysis of the P-QRS-T Complex of the Electrocardiogram by Digital Computer.
Authors: H. V. Pipberger
Journal: Annals of Internal Medicine (1962)

s1 April 1962Automatic Analysis of the P-QRS-T Complex of the Electrocardiogram by Digital Computer.H. V. Pipberger, M.D., F. W. Stallman, SC.D., A. Berson, B.E.E.H. V. Pipberger, M.D.Search for more papers by this author, F. W. Stallman, SC.D.Search for more papers by this author, A. Berson, B.E.E.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-56-4-670_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptComputer programs for automatic analysis of the P-QRS-T complex of electrocardiograms have been developed. Orthogonal 3-lead records are recorded on magnetic tape using FM channels. Previously it had been shown that such records contain the same clinical information used in 12-lead analysis. Tracings are then converted automatically into numerical form to become acceptable to digital computers. More than 3,000 records have been processed.Computer analysis requires first a wave recognition program,i.e., the computer has to be instructed how to recognize beginning and end of waves. This program has been successfully tested, and agreement between computed and visual time measurements... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Washington, D. C. (CI) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1962Volume 56, Issue 4Page: 670-670KeywordsComputersElectrocardiographySoftware tools Issue Published: 1 April 1962 PDF DownloadLoading ...
J Radiologie, Electr et Med Nucleaire, Paris
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Relationship between biochemical, virological, and histological response during interferon treatment of chronic hepatitis C
Authors: M Shiffman
Journal: Hepatology (1997)

The present study was conducted to evaluate the relationship between biochemical, virological, and histological response during the course of interferon therapy. Ninety consecutive patients with well-documented chronic hepatitis C virus (HCV) were treated with 5 MU of interferon alfa-2b three times weekly for 6 months. Liver biopsy was performed, and serum HCV RNA titer was measured before and at the completion of interferon treatment. Normalization of serum alanine transaminase (ALT) concentration (biochemical response) was observed in 50% of patients. In these patients, Knodell score declined significantly from 9.6 ± 0.5 to 5.0 ± 0.5 (P < .01), and 75% became HCV RNA negative. The remaining patients (50%) were biochemical nonresponders; mean Knodell score declined from 9.6 ± 0.5 to 7.7 ± 0.5 (P < .01), and 11% became HCV RNA negative. For both biochemical responders and nonresponders, the decline in Knodell score was confined to the components of hepatic inflammation (piecemeal necrosis + lobular + portal inflammation); no change in fibrosis was observed. Hepatic inflammation declined by 5 points or more in 69% of biochemical responders and 48% of biochemical nonresponders, and by at least 50% from pretreatment values in 74% and 38% of biochemical responders and biochemical nonresponders, respectively. For all patients (both biochemical responders and nonresponders) who remained viremic at the conclusion of interferon therapy, the reduction in hepatic inflammation was a linear function of the decline in HCV RNA titer. We conclude that more than one third of patients who had no biochemical response after 6 months of interferon therapy achieved a similar improvement in hepatic histology as was observed in patients with biochemical response. This improvement in hepatic histology appeared to correlate with a reduction in HCV RNA titer, especially in patients who remained viremic.
HIGHER MEDICAL EDUCATION.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Human rights violations among Bhutanese refugees
Authors: M. H. Proctor
Journal: JAMA (1995)

WHILE WORKING in Kathmandu between November 1994 and January 1995,I visited the Bhutanese refugee camps in the Jhapa and Morang Districts of eastern Nepal (Figure) at the request of the Physicians for Human Rights. I found a situation there that cries out for a constructive solution. Housed in endless rows of split bamboo huts were 88 000 Nepali-speaking former residents of southern Bhutan. As of August 1995, there were 88 624 refugees in the camps.<sup>1</sup>The population increases about 2% to 3% per year as the result of births in the camps and further migration from Bhutan to unify families. An additional 30000 refugees are scattered throughout northern India. The spectrum of medical problems in the camps is fairly typical of refugee populations, according to Martin et al who performed infectious disease surveillance during 1992 and 1993.<sup>2</sup>These investigators recorded crude mortality rates of 1.15 deaths per 10
211. Efficacy and Safety of Gene-Chemo Therapy Using Oncolytic Adenovirus Expressing Uracil Phosphoribosyl Transferase (UPRT) Followed by 5-Fluorouracil Administration in Syngenic Pancreatic and Biliary Cancers in Immunocompetent Adenovirus-Permissive Syrian Hamsters
Journal: Molecular Therapy (2012)
Routine refractions.
Authors: R S Mahto
Journal: BMJ (1971)

ceptives have been more widely publicized.Equally disturbing is the increased ra-e of venereal disease among the young.If the British Medical Association can spend time in warning the public of the health hazards of smoking, why does it consistently neglect its duty in warning young people of the health hazards of sexual promiscuity?-Iam, etc.,
Resident Forum
Authors: Kirsti A. Dyer
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Klinische Wochenschrift, Berlin
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Error in Figure
Authors: Charbel Moussa
Journal: JAMA Neurology (2020)

Paula R. Clemens, MD; Vamshi K. Rao, MD; Anne M. Connolly, MD; Amy D. Harper, MD; Jean K. Mah, MD; Edward C. Smith, MD; Craig M. McDonald, MD; Craig M. Zaidman, MD; Lauren P. Morgenroth, MS; Hironori Osaki, MSc; Youhei Satou, MSc; Taishi Yamashita, PhD; Eric P. Hoffman, PhD; for the CINRG DNHS Investigators
Letter from Tamil Nadu. Primary health care at the village level
Authors: R. A. Root
Journal: JAMA (1988)

The room was bare but for a mound of brown rice in the corner, a small wooden stool missing a leg, and two ceramic pots. The tiny infant lay snugly bundled on a straw mat beside its mother. For the woman, at age 24, this was her third baby. She smiled broadly as she spoke of the baby, who had been delivered at home the evening before, after she had gone into premature labor at 36 weeks. We examined the infant to make sure that there were no signs of umbilical sepsis—the cord had been cut by the grandmother with an unclean knife. The child looked healthy, although small for gestational age. We briefly reviewed with the mother proper breast-feeding technique. Then, touching our palms together in a farewell "namaste," we left the hut. I was accompanying two nurses in Tamil Nadu, South India, as they made their daily "home
Friendly Societies
Authors: A. Cox
Journal: BMJ (1898)

Ouabain acutely depolarizes most types of cells through inhibition of electrogenic Na<sup>+</sup>,K<sup>+</sup> pumping and is a useful tool with which to study conditions that affect electrogenic pumping. Intracellular recording techniques were used with neurons of the guinea pig myenteric plexus/longitudinal muscle preparation exposed to ouabain. Of 35 S neurons exposed to ouabain (1 μM), 15 were hyperpolarized by 10 ± 2 mV, 11 were depolarized by 8 ± 2 mV and the remaining neurons had no change in membrane potential. The nonselective potassium channel antagonist tetraethylammonium chloride (TEA; 0.5 mM) alone evoked modest (&lt;5 mV) and inconsistent changes in the resting membrane potential of S neurons. However, in the presence of TEA, the hyperpolarizing response to 1 μM ouabain was eliminated, and the proportion of cells depolarized by ouabain increased from 31% to 83%. Glibenclamide (10 μM) and 100 nM iberiotoxin did not change the pattern of membrane potential changes induced by 1 μM ouabain. Calcium-free buffer eliminated the hyperpolarization and potentiated the depolarization induced by 1 μM ouabain. Ouabain (5 μM), in either the presence or absence of TEA, induced depolarization in all neurons tested (mean, 15–16 mV), indicating a predominant effect of inhibition of electrogenic pumping. These data suggest that ouabain may directly or indirectly activate myenteric S neuron calcium-sensitive potassium channels as well as inhibit the Na<sup>+</sup>,K<sup>+</sup> pump and that TEA will antagonize the former effect. Chronic exposure (morphine pellets) of guinea pigs to morphine resulted in a partial depolarized state of myenteric neurons, as previously reported. Ouabain (5 μM), either with or without TEA, depolarized neurons from chronically morphine-treated guinea pigs very little (5–6 mV) in comparison with naive neurons (15–16 mV). This supports the conclusion that the depolarized state of morphine-tolerant neurons is associated with a reduction in electrogenic Na<sup>+</sup>,K<sup>+</sup> pumping.
Myeloid derived suppressor cells enhance regulatory T cell suppressive activity via IL-10, iNOS and PDL-2 in cirrhotic patients with sepsis
Authors: Rashi Sehgal, Rakhi Maiwall, Navkiran Kaur, Vijayraghavan Rajan, Shiv Kumar Sarin, Nirupma Trehanpati
Journal: Journal of Hepatology (2020)
SECTION WORK.
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Gastric Function in Health and Disease.
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal