tbuckley/cabot-search huggingface dataset:
Enzastaurin (ENZ) before and concomitant with radiation therapy (RTX) followed by ENZ maintenance therapy in patients with newly diagnosed glioblastoma (GBM) without hypermethylation of the O<sup>6</sup>-methylguanyl DNA-methyltransferase (MGMT) promoter: A multicenter, open-label, uncontrolled phase II study.
Authors: W. Wick, J. Steinbach, S. E. Combs, M. Platten, C. Hartmann, F. K. Wenz, U. Boecker, C. Stoffregen
Journal: Journal of Clinical Oncology (2011)

2007 Background: There is an unmet need to improve efficacy outcome for GBM patients without hypermethylation of the MGMT promoter. Preclinical data indicate potential activity of ENZ, an oral PKC beta inhibitor, together with RTX (Tabatabai, Ann Neurol 2007, 61) in GBM. This single arm phase II study treated GBM patients with unmethylated MGMT promoter with ENZ and RTX. Methods: Patients (pts) with newly diagnosed supratentorial GBM without methylation of the MGMT promoter were eligible. ENZ 250 mg twice daily was given on 7 days before, concomitant with RTX (60 Gy; 5 times 2 Gy per week), and in the maintenance therapy until progression. The study’s primary endpoint was 6-months progression-free survival (PFS-6). The study needed to observe 43 events of progression or death to have 80% power to detect an improvement to 55% compared to 40% PFS-6 rate, observed in the EORTC trial (Hegi, NEJM 2005, 352). Results: Between 10/07 and 07/09 a total of 57 pts were enrolled (median age 57.6 years). ECOG scores were 0 (39 pts), 1 (16 pts) and 2 (2 pts). Complete resection was performed in 25 pts, partial resection in 23 pts, and biopsy in 9 pts. The 57 enrolled pts received 100% median ENZ dose intensity, the 53 pts continuing to RTX received 60 Gy median cumulative RTX dose. Two pts had grade 3/4 possibly drug-related lab adverse events. Eleven pts had grade 3 (5pts), 4 (3pts) and 5 (3pts) non lab toxicity. One pt died after CNS hemorrhage and 2 with infection. The PFS-6 rate was 51.8% (95% CI 38.1-63.9). Conclusions: This is the first trial performed in pts with GBM to publish data, limiting entrance to the molecularly defined unfavorable subgroup of pts with unmethylated MGMT status. Although showing some encouraging PFS-6 results, the study did not reach its primary endpoint. Side effects were manageable and the combination therapy was performed as planned. Further molecular data may identify subgroups of pts that warrant a controlled study to assess the role of ENZ for this pt population.
Cytological Presentation of Malignant Lymphomas and Related Diseases in Effusions
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cytologie sanguine: Normale et pathologique
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cooperative study of radiologic aspects of renovascular hypertension. Bilateral renovascular disease
Authors: J. J. Bookstein
Journal: JAMA (1977)

Abnormal urographic features were present in 60.7% of 250 patients with bilateral disease. The urogram was relatively insensitive in the minority of patients whose lesions were of approximately equivalent severity bilaterally. In bilateral renovascular disease, the urogram demonstrated some surgical prognostic value that was not evident in unilateral renovascular disease. Furthermore, in patients with bilateral disease, the urogram was helpful in deciding between unilateral or bilateral operation. (<i>JAMA</i>237:1706-1709, 1977)
Table of Contents
Authors: Maarten Soeters, Hidde Huidekoper, Marinus Duran, Mariëtte Ackermans, Erik Endert, Eric Fliers, Frits Wijburg, Ronald Wanders, Hans Sauerwein, Mireille Serlie, Zuhair Allebban, Julius Gardin, Nathan Wong, Sharon Sklar, Renee Bess, M Spence, Harrihar Pershadsingh, Darren Henstridge, Josephine Forbes, Sally Penfold, Melissa Formosa, Sonia Dougherty, Anna Gasser, Maximilian De Courten, Mark Cooper, Bronwyn Kingwell, Barbora De Courten, Kay Cox, Valerie Burke, Lawrence Beilin, Ian Puddey, Shino Oba, Chisato Nagata, Kozue Nakamura, Kaori Fujii, Toshiaki Kawachi, Naoyoshi Takatsuka, Hiroyuki Shimizu, Ki Lee, Yoen Kim, Hyo Lim, Young Lee, Yangsoo Jang, Jong Lee, Etsuko Takiguchi, Chika Fukano, Yukari Kimura, Masayo Tanaka, Keiko Tanida, Hidesuke Kaji
Journal: Metabolism (2010)
Prenatal diagnosis of propionic acidemia
Authors: L. Sweetman
Journal: JAMA (1979)

Prenatal diagnosis of a fetus with propionic acidemia has been accomplished by the detection of methylcitrate, a unique metabolite, in the amniotic fluid by liquid partition chromatography and gas chromatographymass spectrometry. The diagnosis was confirmed by demonstration of deficient activity of propionyl-CoA carboxylase in cells cultured from the amniotic fluid and in fetal tissues. In two subsequent pregnancies, methylcitrate was not present in amniotic fluid. Enzyme assay indicated that one fetus was heterozygous and the other was normal, and healthy infants were born at term. The analysis of organic acids in amniotic fluid permits very rapid prenatal diagnosis, usually within 48 hours after obtaining the fluid. It may provide a general method in conditions in which an unusual metabolite can be identified. (<i>JAMA</i>242:1048-1052, 1979)
19-Norsteroids
Journal: JAMA (1976)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Add EPs to list of intraoperative monitors
Journal: JAMA (1981)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A SURGICAL TREATMENT FOR HYPERTROPHIED PROSTATE AND HERNIA IN OLD MEN, WITH A REPORT OF TWENTY-EIGHT CASES.
Authors: GEORGE W. JOHNSON
Journal: JAMA (1898)

Reginald Harrison, F.R.C.S., reports twelve cases of single vasectomy. Seven derived permanent benefit; in the other five, the results were either negative, or it was impossible to trace the patients subsequently. The two cases he reports are as follows: <h3>Case 1.</h3> —Patient, aged 69; his prostate was very large. Prominent symptom was extreme frequency of micturition. No catheter used. Amount of residual urine about an ounce, but for some time the patient urinated about every hour, day and night. Operation was performed with successful result. When the patient was examined five months later, the right testis was found to be atrophied and soft, the left somewhat larger than before. The right side of the prostate underwent shrinkage and was smaller than the opposite lobe. <h3>Case 2.</h3> —Patient, aged 72; complained of great frequency of micturition of ten years' duration, eventually amounting to about every two hours, day and night, sometimes
Synapsed
Authors: Jeffrey Parks
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Immunization Programmes
Authors: M. Adams, I. A. Boyd, B. Broadbent, C. O. S. B. Brook, A. D. C. S. Cameron, F. M. Day, J. Fenton, V. Freeman, D. H. Geffen, B. J. L. Moss, E. H. R. Smithard, T. Standring, F. Summers, W. C. Turner, J. H. Weir
Journal: BMJ (1959)
Drugs for mental disorders of old age
Authors: L. E. Hollister
Journal: JAMA (1975)

EMOTIONAL disorders associated with old age ordinarily are considered to be due to presenile, senile, arteriosclerotic, and mixed types of organic brain syndromes. Functional mental illness has only recently been recognized as a major concomitant of old age. Even slight, so-called normal impairment may trigger excessive anxiety and depression in a rigid, insecure person. Many experienced clinicians view unrecognized depression in old age as a more important problem than that of the organic brain syndromes—it is much more amenable to treatment. About one person in six of those aged 65 years or more have some manifestation of organic brain syndrome. On the other hand, as many as 25% to 30% of the same group have some type of functional disorder, such as depression or neurosis. Many individuals have both organic and functional disorders, but the main point is that age, per se, does not necessarily indicate that the patient's emotional
"QUININ IN INFLUENZAL PNEUMONIA"— USEFULNESS OF CALOMEL
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
HIV prevalence among Washington, DC, residents having abortions
Authors: C. Wolter
Journal: JAMA (1993)

<h3>To the Editor.</h3> —In their recent article, Rosenberg et al<sup>1</sup>used backcalculation methods to reconstruct human immunodeficiency virus (HIV) incidence from acquired immunodeficiency syndrome (AIDS) incidence in subgroups of the population, and then compared the results with directly measured seroprevalence in selected sentinel populations. In this context, it should be noted that both techniques, ie, backcalculation and direct serosurveys, have different shortcomings. These must be addressed before comparing results of the techniques for the purpose of cross-validation. Forecasts based exclusively on AIDS incidence data cannot produce good estimates of recent HIV incidence because of the virus' long and variable incubation period. On the other hand, direct serosurveys based on unlinked testing allow the assessing of trends in recent HIV prevalence but are restricted to readily accessible sentinel populations, which may be subject to selection bias (eg, patients of sexually transmitted disease clinics, pregnant women, or hospitalized patients). Rosenberg et
Use of Lilium longiflorum, cv. Ace Pollen Germination and Tube Elongation As a Bioassay for the Hepatocarcinogens, Aflatoxins
Authors: William V. Dashek, Robin L. Harman, Lee B. Adlestein, William A. Morton, Barbara M. Rapisarda, James C. Chancey, Gerald C. Llewellyn
Journal: Environmental Health Perspectives (1981)

Although various animal tissues are used for bioassay of aflatoxins (B1, B2, G1, G2), a rapid bioassay dependent upon a plant part's response does not exist. Both pollen germination (G) and tube elongation (TE) were enhanced in a 3.0 mM KH2PO4 (K)-containing but AFB1-lacking, modified Dickinson's medium. The B1 did not affect G when K was withheld but K supplementation impaired G above 15 micrograms/ml B1. Without K, 5-20 stimulated but 25 and 30 micrograms/ml B1 inhibited TE which was suppressed by every B1 conc tested in K-containing medium. Addition of NaH2PO4(N) instead of K to medium did not promote G. Slight G stimulation occurred at 16.6 micrograms/ml mixed aflatoxins (MA) in medium lacking either K or N but low G inhibitions were observed with K or N. The MA at 33.3 micrograms/ml reduced G 2.5% in K's of N's absence and 26 or 17% in their presence. While K did not stimulate TE without MA, N did 26%. At 16.6 and 33.3 micrograms/ml MA, TE was reduced 19, 6, 19% and 24, 25, 31%, respectively, in control, K- and N- media. Pollen G and TE were markedly sensitive to G1. Significant inhibitions of Zea mays seed G were observed at 5.8 and 11.6 micrograms/ml B1 but not root elongation (RE) from 0.4-11.6 micrograms/ml. The MA (31.5 micrograms/ml) administered for 72-240 hr did not influence either Arachis hypogeae seed G or RE. However, imbibing 5 cultivars each of Avena sativa (65-117 hr) and Hordeum vulgare (39-89 hr) inhibited RE 4/15-62%. Thus, except for Z. mays, pollen G and TE appear to be more B1-sensitive than seed G and RE. But, the pollen bioassay is less sensitive than both certain animal bioassays (0.025 micrograms/ml) and analytical methodologies (10 pg.).
Erratum: Combined STAT3 and BCR-ABL1 inhibition induces synthetic lethality in therapy-resistant chronic myeloid leukemia
Authors: A M Eiring, B D G Page, I L Kraft, C C Mason, N A Vellore, D Resetca, M S Zabriskie, T Y Zhang, J S Khorashad, A J Engar, K R Reynolds, D J Anderson, A Senina, A D Pomicter, C C Arpin, S Ahmad, W L Heaton, S K Tantravahi, A Todic, R Colaguori, R Moriggl, D J Wilson, R Baron, T O'Hare, P T Gunning, M W Deininger
Journal: Leukemia (2017)
PULMONARY TUBERCULOSIS IN SCHOOLS.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Delayed is better than earley elective intervention after acute myocardial infarction treated with thrombolytic therapy Abid R. Assali, Ali Moustapha, Stefano Sdringola, Joseph Salloum, Mohammad Ghani, Sangeeta Saikia, Susan Hale, Goerge Schroth, Oscar Rosales, Vernon H. Anderson, Richard W. Smalling. UNIVERSITY OF TEXAS MEDICAL SCHOOL AND HERMANN HOSPITAL, HOUSTON, TX
Journal: Journal of the American College of Cardiology (2001)
THE OCCASIONAL EXCITANT ACTION OF THE BROMIDS.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fibrosis Cure?
Authors: Tracy Hampton
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal