tbuckley/cabot-search huggingface dataset:
Abstract 2410: Development of a custom genotyping platform and genetic prediction of prostate cancer risks in sub-Saharan Africa
Authors: Joseph Lachance, Maxine Harlemon, Paidamoyo Kachambwa, Olabode Ajayi, Michelle Kim, Marcia Adams, Elizabeth Pugh, Lindsay Peterson, Timothy Rebbeck
Journal: Cancer Research (2019)

Abstract Prostate cancer is a highly heritable disease that disproportionally affects African and African-American men. With this in mind, the MADCaP (Men of African Descent Carcinoma of the Prostate) Network has developed a custom genotyping platform. This array is optimized for detection of novel genetic associations in sub-Saharan African populations. The MADCaP Array contains approximately 1.6 million markers, many of which overlap the H3Africa Consortium Array and the OncoArray. It includes an imputation backbone that successfully tags 94% of common (MAF &amp;gt; 0.05) genetic variants in African populations (r2 threshold = 0.8). To aid in fine-mapping, the MADCaP Array has a high density of markers in genomic regions surrounding known cancer associations, including 8q24. Markers on the MADCaP Array also include over 27,000 prostate eQTLs. Using the MADCaP Array, we conducted a pilot study of 800 individuals with individual-level phenotype information. These samples include equal numbers of prostate cancer cases and controls, and they were collected from study sites in Ghana, Nigeria, Senegal, and South Africa. Here, we assess the extent to which polygenic risk scores are able to predict prostate cancer risks in African populations. We also identify non-African GWAS signals that replicate well in African populations. Additional analyses in this study include testing whether specific genetic ancestries are over-represented in cases, and quantifying the extent to which runs of homozygosity are found in the genomes of cases and controls. Citation Format: Joseph Lachance, Maxine Harlemon, Paidamoyo Kachambwa, Olabode Ajayi, Michelle Kim, Marcia Adams, Elizabeth Pugh, Lindsay Peterson, Timothy Rebbeck. Development of a custom genotyping platform and genetic prediction of prostate cancer risks in sub-Saharan Africa [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2410.
Janusz Korczak
Authors: Richard L. Golden
Journal: JAMA (1979)

<h3>To the Editor.—</h3> The COMMENTARY "Janusz Korczak, Physician-Humanitarian" (241:2165, 1979) was a poignant exposition of the life and philosophy of this hero of the Warsaw ghetto. In 1978 the Polish government commemorated the 100th anniversary of his birth with the mintage of two silver 100-zlotych coins, a regular issue and a Proba (limited edition strike). A physician thus honored is a relatively uncommon numismatic event. A bust of Dr Korczak is found on the obverse of the Proba.
PORTA'S EXPERIMENTAL RESEARCH ON LIGATURE OF THE ARTERIES.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AUSTRIA
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Global full-court press against HIV, AIDS spurred by player's infection
Authors: M. F. Goldsmith
Journal: JAMA (1991)

IT'S SAFE TO SAY that millions more Americans know the name "Magic" Johnson than have ever heard of Hiroshi Nakajima, MD. As director-general of the World Health Organization (WHO) in Geneva, Switzerland, Nakajima has designated this Sunday World AIDS Day. The intent is to stimulate action on a global scale against the acquired immunodeficiency syndrome. But it was the stunning disclosure 2 weeks ago by Los Angeles Lakers basketball star Earvin "Magic" Johnson of the positive results of his test for the human immunodeficiency virus (HIV) that is expected to galvanize the campaign against AIDS in the United States. Among young people, and particularly among hard-to-reach adolescents in minority groups, seeing that the disease can strike even an athletic hero is likely to do much more to advance the cause of AIDS prevention than years of governmental proclamations and official adjuration. Indeed, after Johnson shared with the country the startling
MILD PARANOIA AND PUBLIC SAFETY.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Leads from the MMWR. High prevalence of iron deficiency anemia among Alaskan Native children
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Biological Consequences of Land Use
Authors: R. E. Munn
Journal: Environmental Health Perspectives (1975)

The primary goals of land-use planning are enunciated. A plea is made for consideration of the total biosphere and not just its separate components. The environmental impact statement process is reviewed and some suggestions made for its strengthening. Moves for international adoption of this process are noted, as well as the concept of eco-development currently under examination by UN agencies.
Long-term Mortality Associated With Aprotinin Following Coronary Artery Bypass Graft Surgery
Authors: Robert H. Habib, Anoar Zacharias, Thomas A. Schwann
Journal: JAMA (2007)

To the Editor: Dr Mangano and colleagues1 investigated the potential long-term effects of aprotinin use following CABG surgery. It appears that 2 important determinants of long-term CABG outcomes were not included in these analyses.
Comparative Placental Morphology and Function
Authors: Felix Beck
Journal: Environmental Health Perspectives (1976)

The distinction between histiotrophic nutrition (in which local macromolecules are chiefly responsible for the maintenance of the embryo) and hemotrophic nutrition (which results from a transfer of material between the maternal and fetal circulations) is made. Placentation in a number of commonly used laboratory animals and in man is described, and it is shown that dependence upon histiotroph and hemotroph varies greatly, not only between species but also at different stages of gestation in a single species. These facts are likely to be reflected in considerably differences in response to certain teratogens; they must be carefully considered when experimental results are extrapolated between species. The significance to man of an agent which has been shown to be teratogenic in a single species of experimental animals should be evaluated in terms of possible differences in placental function between man and that species. This is particularly so if there is a suspicion that the potential teratogen may affect the fetal membranes.
Fortpflanzung: Vererbung: Rassenhygiene.
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effects of dexamethasone on the incidence of acute mountain sickness at two intermediate altitudes
Authors: A. B. Montgomery
Journal: JAMA (1989)

To test the value of dexamethasone acetate for ameliorating acute mountain sickness (AMS), we conducted a double-blind, randomized study that compared the effects of 4 mg of dexamethasone acetate or a placebo (given every six hours for six doses beginning at the time of exposure) at 2700 and 2050 m. Study subjects, who were recruited from health professionals who attended continuing medical education programs at ski resorts in the Rocky Mountains, were classified as having AMS when they reported three or more of the five usual symptoms (headache, insomnia, dyspnea, anorexia, and/or fatigue) on a single day. All symptoms with an intensity of at least grade 2 (moderate) out of 5 were analyzed. At 2700 m, there was a 50% decrease in the mean AMS symptom score in the dexamethasone group (0.94 ±1.11 vs 1.84 ±1.44 [mean±SD]) and the incidence of AMS was 20% of that in the control group (3/38 vs 14/35). At 2050 m, there was no difference between dexamethasone and a placebo in the mean AMS symptom score (1.52 ± 1.50 vs 1.24 ± 1.33) and the incidence of AMS (5/25 vs 4/25). Dexamethasone ameliorates the usual symptoms of AMS at 2700 m but not at 2050 m. (<i>JAMA</i>1989;261:734-736)
THE COMPARATIVE VALUE OF HORSES IN THE PRODUCTION OF DIPHTHERIA ANTITOXIN.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Erratum: Corrigendum: Identification of a mutation in the extracellular domain of the Epidermal Growth Factor Receptor conferring cetuximab resistance in colorectal cancer
Authors: Clara Montagut, Alba Dalmases, Beatriz Bellosillo, Marta Crespo, Silvia Pairet, Mar Iglesias, Marta Salido, Manuel Gallen, Scot Marsters, Siao Ping Tsai, André Minoche, Seshagiri Somasekar, Sergi Serrano, Heinz Himmelbauer, Joaquim Bellmunt, Ana Rovira, Jeff Settleman, Francesc Bosch, Joan Albanell
Journal: Nature Medicine (2012)
Inhibition of endothelial cell survival and angiogenesis by protein kinase A
Authors: Semi Kim, Manjiri Bakre, Hong Yin, Judith A. Varner
Journal: Journal of Clinical Investigation (2002)

Receptors for the provisional ECM are important regulators of angiogenesis. One of these receptors, integrin α5β1, plays a critical role in tumor- and growth factor–induced angiogenesis, because antagonists of this integrin potently inhibit angiogenesis and tumor growth. Here we show that the integrin α5β1 promotes endothelial cell survival during angiogenesis in vivo by suppressing the activity of protein kinase A (PKA). Antagonists of integrin α5β1 activate PKA, which then leads to the activation of caspase-8 and induction of apoptosis. Direct activation of PKA by cAMP or by expression of the PKA catalytic subunit also induces endothelial cell apoptosis, resulting in angiogenesis inhibition in vivo. Our studies indicate that ligation of integrin α5β1 during angiogenesis suppresses an apoptotic program that is dependent on PKA. These studies also indicate that induction of endothelial cell apoptosis in vivo by genetic or pharmacological activation of PKA may be a useful strategy to inhibit angiogenesis.
Eradication of Hepatitis C Virus after Interferon-α Therapy
Authors: Vincent Agnello
Journal: Annals of Internal Medicine (1995)

Letters15 March 1995Eradication of Hepatitis C Virus after Interferon-α TherapyVincent AgnelloVincent AgnelloSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-122-6-199503150-00013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I agree with Romeo and colleagues [1] that testing liver biopsy specimens for hepatitis C virus (HCV) RNA is useful in monitoring therapy for HCV infection, but their conclusion is incorrect. They claim that a polymerase chain reaction (PCR) assay that is negative for HCV RNA in a liver biopsy specimen indicates eradication of the virus. As the authors indicated, the sensitivity of their PCR assay is 5 × 104 HCV particles/mL of serum, which is the limit of sensitivity of the assay because of the inefficiency of the reverse transcriptase step in the method. Thus, approximately ...References1. Romeo R, Pol S, Berthelot P, Brechot C. Eradication of hepatitis C virus RNA after α-interferon therapy. Ann Intern Med. 1994; 121:276-7. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByLong-term follow-up of sustained responders to interferon therapy, in patients with chronic hepatitis CHigh rate of chronicity in HCV infection determined by antibody confirmatory assay and PCR in 4110 patients during long-term follow-upHepatitis C virus genotypes in the liver and serum of patients with chronic hepatitis C 15 March 1995Volume 122, Issue 6Page: 474-475KeywordsBiopsyBloodHepatitis C virusInfectious hepatitisLiverPolymerase chain reactionRNA Issue Published: 15 March 1995 CopyrightCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
From the editors
Authors: Lucy Bird, Kirsty Minton, Olive Leavy, Yvonne Bordon, Man Tse, Lucie Wootton, Lewis Packwood, Simon Bradbrook, Susanne Harris, Vicky Summersby, Patrick Managing, Judith Shadwell, Simon Fenwick, Natalie Smith, Jacques Smit, Laura Corns, Deborah Anthony, Marketing Managers, Tim Redding, Leah Rodriguez
Journal: Nature reviews. Immunology (2010)
Medical News
Journal: JAMA (1975)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lactic Acidosis
Authors: Mark J. Rumbak
Journal: Annals of Internal Medicine (1990)

Letters and Corrections1 August 1990Lactic AcidosisMark J. Rumbak, MDMark J. Rumbak, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-113-3-254_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors:I read with interest the article by Cooper and colleagues (1) on the use of bicarbonate in critically ill patients. Good evidence suggests that deterioration of myocardial contractility observed with lactic acidosis correlates more closely with the intracellular pH than the arterial pH (2). In low flow states the arterial pH may not correlate with the intracellular pH or the mixed venous pH, which may fall even when the arterial pH is normal or low (due to hyperventilation) (3). If bicarbonate is given to a patient with a lactic acidosis, then CO2and H+are produced. The...References1. CooperWalleyWiggsRussell DKBJ. Bicarbonate does not improve hemodynamics in critically ill patients who have lactic acidosis. Ann Intern Med. 1990;112:492-8. LinkGoogle Scholar2. BersinArieff RA. Improved hemodynamic function during hypoxia with carbicarb, a new agent for the management of acidosis. Circulation. 1988;77:227-33. CrossrefMedlineGoogle Scholar3. WeilRackowTrevino MER. Differences in the acid-base state between venous and arterial blood during cardiopulmonary resuscitation. N Engl J Med. 1986;315:153-6. CrossrefMedlineGoogle Scholar4. WeilGazmuriRackow MRE. Issues in cardiopulmonary resuscitation. In: Furhman BP, Shoemaker WC, eds. Critical Care, v 10. Fullerton, California: Society of Critical Care Medicine; 1989: 445. Google Scholar5. ClancyCingolaniTaylor RHR. Influence of sodium bicarbonate on myocardial performance. Am J Physiol. 1967;212: 917-23. CrossrefMedlineGoogle Scholar1. CooperWalleyWiggsRussell DKBJ. Bicarbonate does not improve hemodynamics in critically ill patients who have lactic acidosis. Ann Intern Med. 1990;112:492-8. LinkGoogle Scholar1. CooperWalleyWiggsRussell DKBJ. Bicarbonate does not improve hemodynamics in critically ill patients who have lactic acidosis. Ann Intern Med. 1990;112:492-8. LinkGoogle Scholar1. CooperWalleyWiggsRussell DKBJ. Bicarbonate does not improve hemodynamics in critically ill patients who have lactic acidosis. Ann Intern Med. 1990;112:492-8. LinkGoogle Scholar2. GrafLeachArieff HWA. Evidence for a detrimental effect of bicarbonate therapy in hypoxic lactic acidosis. Science. 1985;227: 754-6. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: The University of Tennessee College of Medicine Memphis, TN 38163 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1990Volume 113, Issue 3Page: 254-256KeywordsBicarbonatesFallsLactic acidosis Issue Published: 1 August 1990 PDF DownloadLoading ...