HEMOLYTIC REACTIONS FOLLOWING TRANSFUSIONS OF BLOOD OF THE HOMOLOGOUS GROUP, WITH THREE CASES IN WHICH THE SAME AGGLUTINOGEN WAS RESPONSIBLE
Authors: ALEXANDER S.  WIENER, H. RAYMOND  PETERS
Journal: Annals of Internal Medicine (1940)

Article1 June 1940HEMOLYTIC REACTIONS FOLLOWING TRANSFUSIONS OF BLOOD OF THE HOMOLOGOUS GROUP, WITH THREE CASES IN WHICH THE SAME AGGLUTINOGEN WAS RESPONSIBLEALEXANDER S. WIENER, M.D., H. RAYMOND PETERS, M.D., F.A.C.P.ALEXANDER S. WIENER, M.D.Search for more papers by this author, H. RAYMOND PETERS, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-13-12-2306 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe discovery16, 17in 1900 of the isoagglutination reaction was one of the most important steps in the history of blood transfusion, since when donors of the same blood group as the patient are used, transfusions are practically free from danger. Even after this discovery was generally adopted and applied, however, occasional hemolytic reactions continued to occur. In the earlier days, practically all of these reactions could be traced to mistakes in blood grouping (Bordley4) of the patient, donor or both, and even at the present time such unnecessary errors are made too frequently.‡Besides the hemolytic reactions caused by...References1. BAKER SL: Urinary suppression following blood transfusion, with report of case probably due to overheating blood, Lancet, 1937, i, 1390. CrossrefGoogle Scholar2. BAUER M: Ein Bluttransfusion Zwischenfall bei wiederholter Verwendung des gleichen Spenders, Ärztl. Sachverst. Ztg., 1935, xli, 1. Google Scholar3. BLINOV N: Die Isohämoagglutinationsuntergruppen A1 und A2 und ihre praktische Bedeutung für die Bluttransfusion, Deutsch. Ztschr. f. Chir., 1934, ccxliii, 400. CrossrefGoogle Scholar4. BORDLEY J: Reactions following transfusion of blood with urinary suppression, Arch. Int. Med., 1931, xlvii, 288. CrossrefGoogle Scholar5. COCA AF: Selection of donors for blood transfusion, with special reference to preliminary blood tests and use of universal donor, Am. Jr. Med. Technol., 1938, iv, 28. Google Scholar6. CULBERTSONRATCLIFFE CGAW: Reaction following intragroup blood transfusion. Irregular agglutinin demonstrated by the sensitive centrifuge test method, Am. Jr. Med. Sci., 1936, cxcii, 471. CrossrefGoogle Scholar7. DAVIDSOHN I: A method for recognition of blood subgroups A1 and A2, as a means of avoiding transfusion reactions, Jr. Am. Med. Assoc., 1939, cxii, 713. CrossrefGoogle Scholar8. DEGOWIN EL: Hemolytic transfusion reaction from use of a universal donor, Jr. Am. Med. Assoc., 1937, cviii, 296. CrossrefGoogle Scholar9. DEGOWINBALDRIDGE ELCW: Fatal anuria following blood transfusion. Inadequacy of present tests for incompatibility, Am. Jr. Med. Sci., 1934, clxxxviii, 555. CrossrefGoogle Scholar10. GOLDRINGGRAEF WI: Nephrosis with uremia following transfusion with incompatible blood, Arch. Int. Med., 1937, xcxii, 471. Google Scholar11. HESSEFILATOV ERAN: Complications following transfusions, Sovet. khir., 1936, no. ix, 408. Google Scholar12. HOXWORTH PI: Personal communication. Google Scholar13. JOHNSONCONWAY RAJF: Urinary suppression and uremia following transfusion of blood, Am. Jr. Obst., and Gynec., 1933, xxvi, 255. CrossrefGoogle Scholar14. JONSSON B: Zur Frage der heterospezifischen Schwangerschaft, Acta path. et microbiol. scand., 1936, xiii, 424. Google Scholar15. KEYNES G: Blood transfusion, p. 96, Oxford, London (1922). Google Scholar16. LANDSTEINER K: Zur Kenntnis der antifermentativen, lytischen und agglutinierenden Wirkungen des Blutserums, und der Lymphe, Zentralbl. f. Bakteriol., 1900, xxvii, 357. Google Scholar17. LANDSTEINER K: Über Agglutinationserscheinungen normalen menschlichen Blutes, Wien. klin. Wchnschr., 1901, xiv, 1132. Google Scholar18. LANDSTEINERLEVINE KP: On isoagglutinin reactions of human blood other than those defining the blood groups, Jr. Immunol., 1929, xvii, 1. Google Scholar19. LANDSTEINERLEVINEJANES KPML: On the development of isoagglutinins following transfusions, Proc. Soc. Exper. Biol. and Med., 1928, xxv, 572. Google Scholar20. LANDSTEINERWIENER KAS: An agglutinable factor in human blood recognized by immune sera for rhesus blood, Proc. Soc. Exper. Biol., and Med., 1940, xliii, 223. CrossrefGoogle Scholar21. LEVINEMABEE PJ: Dangerous "universal donor" detected by direct matching of bloods, Jr. Immunol., 1923, viii, 425. Google Scholar22. LEVINESTETSON PRE: An unusual case of intra-group agglutination, Jr. Am. Med. Assoc., 1939, cxiii, 126. CrossrefGoogle Scholar23. MANDELBAUM H: Hemolytic reaction following blood transfusion; report of a case of intra-group incompatibility, ANN. INT. MED., 1939, xii, 1699. Google Scholar24. MARTINET R: Contribution a l'étude des caractères sanguins M et N, Thése No. 1601, Univ. de Genève, Liege, 1936. Google Scholar25. MCCANDLESS HG: A hemolytic blood transfusion reaction with oliguria, Jr. Am. Med. Assoc., 1935, cv, 952. CrossrefGoogle Scholar26. MOSONYI L: Das Auftreten von Immun-Isoantikörpern nach mehrmahliger Transfusion, Klin. Wchnschr., 1936, xv, 1675. CrossrefGoogle Scholar27. NETER E: Observations on abnormal isoantibodies following transfusions, Jr. Immunol., 1936, xxx, 255. Google Scholar28. OEHLECKER F: Direct vein-to-vein transfusion of blood, Arch. f. klin. Chir., 1921, cxvi, 705. Google Scholar29. PARRKRISCHNER LWH: Hemolytic transfusion fatality with donor and recipient in the same blood group, Jr. Am. Med. Assoc., 1932, xcviii, 47. CrossrefGoogle Scholar30. PINCOFFSPETERS MCHR: In preparation. Google Scholar31. RIDDELL VH: Blood transfusion, Oxford University Press, London 1939. Google Scholar32. ROBINSON DR: Surg., Gynec. and Obst. (in press). Google Scholar33. SCHAEFERWIENER GAS: Limitations in the use of preserved blood for transfusions, Quart. Bull. Sea View Hosp., 1939, v, 17. Google Scholar34. SMITHHAMAN CEJO: Reaction following blood transfusion; report of unusual case, Calif. and West. Med., 1934, xli, 157. Google Scholar35. THALHIMER W: Hemoglobinuria after a second transfusion with the same donor, Jr. Am. Med. Assoc., 1921, lxxvi, 1345. Google Scholar36. VON DEESTENCOSGROVE HTSA: Renal insufficiency following blood transfusion; recovery after venesection, ANN. INT. MED., 1933, vii, 105. Google Scholar37. WIENER AS: Blood groups and blood transfusion, 1939, 2d edition, C. C. Thomas, Springfield, Ill. Google Scholar38. WIENER AS: Technique of blood grouping tests preliminary to blood transfusions, Am. Jr. Clin. Path., 1939, ix, 145. CrossrefGoogle Scholar39. WIENER AS: Unpublished observations. Google Scholar40. WIENERSCHAEFER ASG: Limitations in the use of preserved blood for transfusions, Med. Clin. N. Am., 1940, xxiv, 705. CrossrefGoogle Scholar41. ZACHO A: "Incompatibility" between blood of same blood type due to presence of irregular agglutinin and of hitherto undescribed receptor, Hospitalstid., 1935, 225. Google Scholar42. ZACHO A: "Unverträglichkeit" zwischen Blutproben von gleichen Blutypus, beruhend auf dem Vorhandsein eines irregulären Agglutinins gegenüber einen bisher unbekannten Rezeptor, Ztschr. f. Rassenphysiol., 1936, viii, 1. Google Scholar43. PONDMAN A: Moeilijkheden bij. Bloedgroepbepaligen (Difficulties in blood group determination), Nederl. Tidjschr. von Geneesk., 1938, lxxxii, 6111. Google Scholar44. WIENEROREMLANDHYMANSAMWICK ASBHMAAA: Transfusion reactions. Experiences with more than 3000 blood transfusions, Am. Jr. Clin. Path., in press. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Including case cited in addendum.†Received for publication March 11, 1940.Aided by a grant from the Committee on Scientific Research of the American Medical Association.From the Transfusion Division of the Department of Laboratories of the Jewish Hospital of Brooklyn, N. Y. and the Department of Medicine of the University of Maryland, Baltimore, Md.‡With regard to suitable technic of grouping and cross-matching, cf.38§Separate report in press (Robinson, D. R.: Surg., Gynec. and Obst.). 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