tbuckley/cabot-search huggingface dataset:
AMERICAN MEDICINE BECOMES A MONTHLY.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Endothelin association with the cultured rat kupffer cell: Characterization and regulation*1
Authors: K STEPHENSON
Journal: Hepatology (1995)

Circulating endothelin (ET) levels are elevated in conditions such as endotoxemia, hepatic ischemia-reperfusion injury, or orthotopic liver transplantation, and this potent peptide may contribute to hepatic pathophysiology. We measured the surface binding of [125I]ET-1 to rat Kupffer cells in primary culture at 4°C; the apparent dissociation constant (Kd) was 270 pmol/L, and the apparent Bmax was 3,000 receptors/cell. At 37°C, total association (surface binding plus internalization) was much greater than at 4°C, indicating that internalization of the receptor-ligand complex is rapid; the apparent Kd was 30 pmol/L, comparable with other reports for hepaticderived cells. Studies using [125i]ET-1, [125I]ET-3, and specific ET (ant)agonists showed that Kupffer cells possess predominantly ETB type receptors. Prior treatment with 500 pmol/L unlabeled endothelin rapidly (<15 minutes) occluded 60% of subsequent [1251]ET association; using 5 nmol/L unlabeled ET, this occlusion occurred within 1 minute. [1251]ET association with Kupffer cells was unaffected by short-term (≈-1 hour) treatment with cyclic adenosine monophosphate (cAMP), but long-term (20 hour) treatment resulted in a twofold increase in [1251]ET association with no change in the apparent Kd. Stimulation of protein kinase C in Kupffer cells by phorbol 12-myristate acetate had a dual regulatory effect on [125I]ET association. Short-term (<1 hour) treatment with phorbol 12-myristate acetate decreased [1251]ET-3 association by 50%, whereas prolonged treatment (20 hour) increased association twofold. In both cases, the apparent Kd for [1251]-endothelin was unaltered.
This Issue At A Glance
Authors: Lori Baker Schena, John Kerrison
Journal: Ophthalmology (2012)

Li et al (p. 90) evaluated the effects of graft rejection following Descemet's stripping automated endothelial keratoplasty (DSAEK) on endothelial cell loss over time in patients with Fuchs' endothelial dystrophy. In this retrospective case study, which included 615 eyes of 415 Fuchs' dystrophy patients, the authors identified 45 cases of graft rejection (7.3%) in the patients with at least 6 months of follow up. The greatest number of rejections occurred between postoperative months 12 and 18. Endothelial cell loss was recorded at 1, 2, 3, and 4 years following DSAEK surgery.
Résultats à court terme à la suite d’une dissection sous-muqueuse endoscopique de larges tumeurs colorectales protubérantes
Journal: Endoscopy (2018)

Peu de données cliniques sont disponibles concernant les résultats à court terme du traitement endoscopique d’adénomes protubérants (AP). Dans cette étude monocentrique rétrospective, les auteurs ont analysé les résultats à court terme de l’ESD pour les AP.
Azathioprine-induced plasmacytosis
Authors: R. C. Kathol
Journal: JAMA (1981)

AN INCREASE in bone marrow plasma cells is most commonly associated with plasma cell dyscrasias. Klein and Block,<sup>1</sup>however, showed that multiple myeloma accounted for only 20% of those with this finding. We report a case in which plasmacytosis was augmented in both bone marrow and peripheral smear by azathioprine overdose. <h3>Report of a Case</h3> A middle-aged woman had a 30-year history of rheumatoid arthritis; she had required aspirin, prednisone, indomethacin, surgery, and acupuncture for severe rheumatoid disease. She had a polyclonal gammopathy and high-titer rheumatoid factor (1:4,120). For four weeks prior to our evaluation, she mistakenly took 300 mg (5.66 mg/ kg/day) rather than 85 mg (1.42 mg/ kg/day) of azathioprine daily for exacerbation of her rheumatoid symptoms. She had not received indomethacin in four years and was receiving prednisone and aspirin prior to starting azathioprine treatment. She was admitted with bloody emesis. Oral temperature was 38.8 °C.
781 MEDICAL PROCEDURES AS A RISK FACTOR FOR HCV INFECTION IN DEVELOPED COUNTRIES: DO WE NEGLECT A SIGNIFICANT PROBLEM IN MEDICAL CARE?
Authors: K. Deterding, J. Wiegand, N. Gruener, D. Becker, M. Cornberg, M.C. Jung, M.P. Manns, H. Wedemeyer
Journal: Journal of Hepatology (2008)
Sex and gender bias in anatomy and physical diagnosis text illustrations
Authors: K. D. Mendelsohn
Journal: JAMA (1994)

<h3>Objective.</h3> —To examine the sex and gender distribution of illustrations in two atlases, five anatomy texts, and five physical diagnosis texts. <h3>Design.</h3> —Of 4060 illustrations that were identifiable by sex and gender in 12 commonly used anatomy and physical diagnosis textbooks, 3827 were categorized by two reviewers as female, male, or neutral. <h3>Results.</h3> —Females were represented, on average, in 21.2% of the anatomy text illustrations; males were represented, on average, in 44.3%; 34.4% of the illustrations were neutral. Of the nonreproductive anatomy illustrations, a mean of 11.1% (range, 4.6% to 23.8%) depicted women and 43.1% (range, 35.4% to 56.2%) depicted men. Of nonreproductive anatomy illustrations, a mean of 45.8% (range, 27.2% to 59.9%) were neutral. Overall, the physical diagnosis text illustrations demonstrated a more equal sex and gender distribution (21.5% female and 24.8% male). However, in the reproductive chapters of the physical diagnosis texts, females were depicted in a mean of 71.1% (range, 63.2% to 79.0%) of the illustrations, while in the nonreproductive chapters, females were depicted in 8.8% of total illustrations. <h3>Conclusions.</h3> —In anatomy and physical diagnosis texts, women are underrepresented in illustrations of nonreproductive anatomy. The finding that males are depicted in a majority of nonreproductive anatomy illustrations may perpetuate the image of the male body as the normal or standard model for medical education. (<i>JAMA</i>. 1994;272:1267-1270)
HAVE A HEART
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Influenza Surveillance: A Perpetual Campaign for Elusive Victories
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Schools smoking prevention programme based on "stages of change" model does not work
Journal: BMJ (1999)

Behavioural counselling in primary care leads to improvements in health behaviour Behavioural counselling in primary care leads to greater improvements in health behaviour than standard health education and advice in patients at increased risk of coronary heart disease.Previous studies of health promotion and lifestyle counselling in primary care have produced disappointing results.Steptoe et al (p 943) found in a randomised trial that brief behavioural counselling on the basis of the "stage of change" model stimulated greater reductions in dietary fat intake and number of cigarettes smoked, and greater increases in physical activity than did usual care.The results suggest that behavioural counselling in primary care may be a useful strategy in the prevention of coronary heart disease.
Uremic Pericarditis
Authors: Kurt H. Stenzel
Journal: JAMA (1974)

<h3>To the Editor.—</h3> Eliasson and Murphy's article on uremic pericarditis (229:1634, 1974) is of interest, but overinterpretation of their data, based on only three cases, would be hazardous. One important factor, apparently overlooked by the authors, was that all three of their patients developed pericarditis at the beginning of dialysis therapy (case 1, 12 days after hospitalization for "uremia"; case 2, 20 days after; and case 3, two days after hemodialysis was initiated). It is our experience that uremic pericarditis, occurring before or shortly after dialysis is initiated, usually responds very well to any therapy, as long as aggressive dialysis is part of the regimen, and precipitating factors are corrected. The difficult therapeutic problems pertain to those patients who develop pericarditis with increasing effusion or tamponade after their conditions have been stabilized on an intermittent dialysis program. Uremic pericarditis in this setting is often associated with systemic infection or surgery.
Assessing Exposures of Health-Care Personnel to Aerosols of Ribavirin—California
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medical Education, Registration and Hospital Service
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ANY QUESTIONS
Authors: A C Chu
Journal: BMJ (1995)

<h3>Background</h3> Myeloid-derived suppressor cells (MDSCs) represent a negative prognostic factor in malignant melanoma. These cells are generated under chronic inflammatory conditions typical of cancer. The transcription factor signal transducer and activator of transcription 3 (STAT3) orchestrates MDSC accumulation and acquisition of immunosuppressive properties. Here we studied STAT3 inhibition by Napabucasin as a way to block MDSC accumulation and activity and its potential to treat malignant melanoma. <h3>Methods</h3> <i>In vitro</i> generated murine MDSC and primary MDSC from melanoma-bearing mice were used to investigate the effects of Napabucasin on MDSC <i>in vitro</i>. The <i>RET</i> transgenic mouse model of malignant melanoma was used to examine Napabucasin therapy efficiency and its underlying mechanisms <i>in vivo</i>. Furthermore, STAT3 activation and its correlation with survival were explored in MDSC from 19 patients with malignant melanoma and human <i>in vitro</i> generated monocytic myeloid-derived suppressor cell (M-MDSC) were used to evaluate the effects of Napabucasin. <h3>Results</h3> Napabucasin was able to abrogate the capacity of murine MDSC to suppress CD8<sup>+</sup> T-cell proliferation. The STAT3 inhibitor induced apoptosis in murine MDSC, significantly increased expression of molecules associated with antigen processing and presentation, as well as slightly decreased expression of immunosuppressive factors on these cells. <i>RET</i> transgenic mice treated with Napabucasin showed prolonged survival accompanied by a strong accumulation of tumor-infiltrating antigen-presenting cells and activation of CD8<sup>+</sup> and CD4<sup>+</sup> T cells. Interestingly, patients with malignant melanoma with high expression of activated STAT3 in circulating M-MDSC showed significantly worse progression-free survival (PFS) than patients with low levels of activated STAT3. In addition, Napabucasin was able to abrogate suppressive capacity of human <i>in vitro</i> generated M-MDSC. <h3>Conclusion</h3> Our findings demonstrate that STAT3 inhibitor Napabucasin completely abrogated the immunosuppressive capacity of murine MDSC and human M-MDSC and improved melanoma-bearing mouse survival. Moreover, patients with malignant melanoma with high expression levels of activated STAT3 in M-MDSC displayed shorter PFS, indicating its role as a promising therapeutic target in patients with malignant melanoma and a predictive marker for their clinical outcome.
Abstract A47: IL-4 receptor-targeted delivery of liposomal doxorubicin and siRNA to tumor
Authors: Guruprasath Padmanaban, Sri Murugan Poongkavithai Vadevoo, Lianhua Chi, Byung-Heon Lee
Journal: Cancer Research (2015)

Abstract Targeted delivery of imaging agents and therapeutics to tumors would provide early detection and increased therapeutic efficacy against cancer. Using phage displayed-random peptide libraries, we have identified IL4RPep-1 (IL-4 receptor-binding peptide-1), CRKRLDRNC, that binds to IL-4 receptor (IL4R). IL4R is over-expressed on many types of cancer cells including lung cancer and breast cancer. Peptides have smaller size and in turn may exert better tissue penetration than bulky antibodies. IL4RPep-1 bound to H226 lung tumor cells that over-express IL4R, while little binding was observed in H460 lung tumor cells that express IL4R at low levels. When injected intravenously into nude mice bearing a subcutaneous H226 tumor, Cy7.5 near-infrared fluorescence dye-conjugated IL4RPep-1 selectively homed to tumor. IL4RPep-1-labeled liposomes containing doxorubicin showed more efficient anti-tumor growth activity than untargeted liposomes. In addition, IL4RPep-1-labeled, branched-type polyethyleneimine nanoparticles containing Bcl-xL siRNA more efficiently knocked down Bcl-xL expression and showed higher cytotoxic effect on cancer cells over-expressing IL4R than cancer cells expressing IL4R at low levels. These results suggest that IL4RPep-1 could be a useful probe for affinity-based imaging and drug delivery to tumor that over-expressing IL4R. Citation Format: Guruprasath Padmanaban, Sri Murugan Poongkavithai Vadevoo, Lianhua Chi, Byung-Heon Lee. IL-4 receptor-targeted delivery of liposomal doxorubicin and siRNA to tumor. [abstract]. In: Abstracts: AACR Special Conference on Cellular Heterogeneity in the Tumor Microenvironment; 2014 Feb 26-Mar 1; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2015;75(1 Suppl):Abstract nr A47. doi:10.1158/1538-7445.CHTME14-A47
The Cover
Authors: M. Therese Southgate
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correspondence
Authors: M.K. Polano
Journal: British Journal of Dermatology (1977)

Journal Article Correspondence Get access M.K. Polano M.K. Polano Academisch Ziekenhuis, Afdeling Dermatologie, Leiden Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 97, Issue 1, 1 July 1977, Page 113, https://doi.org/10.1111/j.1365-2133.1977.tb15440.x Published: 01 July 1977
Home Monitoring Service Improves Mean Arterial Pressure in Patients with Essential Hypertension: A Randomized Controlled Trial
Authors: Mary A. M. Rogers, David Small, Debra A. Buchan, Carl A. Butch, Christine M. Stewart, Barbara E. Krenzer, Harold L. Husovsky
Journal: Circulation (2001)

P99 While the use of telecommunication systems in medicine has been increasing, there have been few trials to assess the efficacy of such technology for improving blood pressure (BP) in patients with essential hypertension. A randomized controlled trial (RCT) was conducted to assess the efficacy of an home monitoring service which utilized automatic transmission of BP data over telephone lines, conversion of the data into report form by computer, and facsimile transmission of the form weekly to physicians and patients. One hundred and eleven patients were randomized to either home service or usual care and followed for a median of 11 weeks. The primary endpoint was change in mean arterial pressure (MAP) which was assessed using a 24-hour ambulatory blood pressure monitoring (ABPM) device at both baseline and exit. There was a 3.0 mm Hg decline in MAP from baseline to exit for patients using the home service and a 1.5 mm Hg increase in MAP for patients receiving usual care (p=0.0139). There was a 2.1 mm Hg decline in average diastolic BP (DBP) in the home service group and a 2.3 mm Hg increase in the usual care group (p=0.0120). In addition, the proportion of 24-hour DBP readings above target levels decreased by 6.8% in patients receiving home service, but increased by 6.2% in patients receiving usual care (p=0.0057). The reduction in BP was evident for both genders, for each ethnic group, and for both younger and older patients. For African-Americans, MAP declined by 9.6 mm Hg for those receiving the home service and increased by 5.25 mm Hg for those receiving usual care (p=0.0469). The difference in MAP between the two study arms remained significant after adjustment for patient characteristics. The decrease in BP for home service was, in part, due to more frequent changes in dose and/or type of medication during the course of the trial. This was the first RCT of a home BP service that did not rely on patient self-report and which used 24-hour ABPM at baseline and at exit to assess usual BP. It is recommended that patients with essential hypertension, who are in the process of evaluation for a change in antihypertensive therapy, utilize a home monitoring service.