Ciprofloxacin versus Tobramycin for Neutropenic Fevers
Authors: Gerald R. Donowitz, James E. Peacock Jr.
Journal: Annals of Internal Medicine (2003)

Letters4 March 2003Ciprofloxacin versus Tobramycin for Neutropenic FeversGerald R. Donowitz, MD and James E. Peacock Jr., MDGerald R. Donowitz, MDUniversity of Virginia; Charlottesville, VA 22908 (Donowitz)Wake Forest University; Winston-Salem, NC 27157 (Peacock Jr.)Search for more papers by this author and James E. Peacock Jr., MDUniversity of Virginia; Charlottesville, VA 22908 (Donowitz)Wake Forest University; Winston-Salem, NC 27157 (Peacock Jr.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-138-5-200303040-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Drs. Bodey, Rolston, and Raad question the low antibiotic response rate of our study compared with those of previous series. The difference involves study design, not drug efficacy. In our study, addition of any antifungal or antiviral agent was one of the definitions of failure. Patients were not excluded if their febrile episode proved to be viral or fungal. Had addition of nonantibacterial agents been allowed as suggested by consensus panels (1), response rates of 61% to 69% would have been noted. As we mentioned in the Discussion, studies with similar design have had similar responses (2).Drs. ...References1. From the Immunocompromised Host Society. The design, analysis, and reporting of clinical trials on the empirical antibiotic management of the neutropenic patient. Report of a consensus panel. J Infect Dis. 1990;161:397-401. [PMID: 2179421] CrossrefMedlineGoogle Scholar2. Cordonnier C, Herbrecht R, Pico JL, Gardembas M, Delmer A, Delain M, . Cefepime/amikacin versus ceftazidime/amikacin as empirical therapy for febrile episodes in neutropenic patients: a comparative study. The French Cefepime Study Group. Clin Infect Dis. 1997;24:41-51. [PMID: 8994754] CrossrefMedlineGoogle Scholar3. Chow JW, Fine MJ, Shlaes DM, Quinn JP, Hooper DC, Johnson MP, . Enterobacter bacteremia: clinical features and emergence of antibiotic resistance during therapy. Ann Intern Med. 1991;115:585-90. [PMID: 1892329] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: University of Virginia; Charlottesville, VA 22908 (Donowitz)Wake Forest University; Winston-Salem, NC 27157 (Peacock Jr.) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoCiprofloxacin plus Piperacillin Compared with Tobramycin plus Piperacillin as Empirical Therapy in Febrile Neutropenic Patients James E. Peacock Jr. , Deirdre A. Herrington , James C. Wade , Hillard M. Lazarus , Michael D. Reed , Jane W. Sinclair , Daniel C. Haverstock , Steven F. Kowalsky , David D. Hurd , Deborah A. Cushing , Colleen P. Harman , and Gerald R. Donowitz Ciprofloxacin versus Tobramycin for Neutropenic Fevers Gerald P. Bodey , Kenneth V.I. Rolston , and Issam I. Raad Ciprofloxacin versus Tobramycin for Neutropenic Fevers Darren R. Linkin and Neil Fishman Metrics 4 March 2003Volume 138, Issue 5Page: 436KeywordsAntibioticsDrugsEnterobacterFever of unknown originFeversHyperthermiaInfectious diseasesNeutropeniaPopulation statisticsToxicity ePublished: 4 March 2003 Issue Published: 4 March 2003 CopyrightCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...