tbuckley/cabot-search huggingface dataset:
Foreword
Authors: Robert M. Wachter
Journal: Annals of Internal Medicine (1999)

The Hospitalist Movement in the United States16 February 1999ForewordRobert M. Wachter, MDRobert M. Wachter, MDUniversity of California, San Francisco; San Francisco, CA 94143Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-130-4-199902160-00012 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail During the 20th century, the U.S. hospital has been the site of breathtaking technological progress and equally remarkable variation and iatrogenesis. Even as our profession has turned its attention to the outpatient world in which the majority of our patients reside, we neglect the hospital at our peril. Most of us entered this world inside its walls, and most of us will leave it there. And in this era in which U.S. health care is finally being forced to confront the immutable economic laws of nature, the hospital continues to be the place where we spend about one third of ...Reference 1. Wachter RM, Goldman L. The emerging role of “hospitalists” in the American health care system. N Engl J Med. 1996;335:514-7. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: University of California, San Francisco; San Francisco, CA 94143Corresponding Author: Robert M. Wachter, MD, Department of Medicine, University of California, San Francisco, Box 0120, University of California, San Francisco, San Francisco, CA 94143-0120. Nextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe Hospitalist Movement Lawrence A. Starr The Hospitalist Movement Charles E. Hofmann The Hospitalist Movement Darius A. Rastegar The Hospitalist Movement Bradley Flansbaum , Steven A. Wartman , and Steven J. Walerstein The Hospitalist Movement Robert M. Wachter The Hospitalist Movement Lee Goldman The Ambulist, a Counterpart of the Hospitalist Vincent A. DeLuca Jr. Metrics Cited ByRevenue enhancement for the practice and the endoscopic ambulatory surgery centerPediatric Hospitalists:What Do We Know, and Where Do We Go From Here?The Hospitalist MovementLawrence A. Starr, MDThe Hospitalist MovementCharles E. Hofmann, MD 16 February 1999Volume 130, Issue 4_Part_2Page: 337KeywordsHealth careHealth care policyHealth economicsHospitalistsInpatientsMedical educationOutpatient clinics Issue Published: 16 February 1999 CopyrightCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Occupational Asthma
Authors: Moira Chan-Yeung, Jean-Luc Malo
Journal: New England Journal of Medicine (1995)

Occupational asthma has become the most prevalent occupational lung disease in developed countries.15 Surveillance programs in the United Kingdom4 and in British Columbia, Canada,5 indicate that asthma is the most frequently reported occupational lung condition, accounting for 26 percent and 52 percent of such reports, respectively.Asthma affects 5 to 10 percent of people worldwide. The proportion of newly diagnosed cases of asthma in adults that are due to occupational exposure is unknown. In the United States, it has been estimated to be 15 percent,6 which is similar to estimates in Japan.7 Since the treatment of choice for occupational . . .
Public Health Focus: Physical Activity and the Prevention of Coronary Heart Disease
Journal: JAMA (1993)

Coronary heart disease (CHD) is the leading cause of mortality in the United States: each year, CHD is newly diagnosed in approximately 1.5 million persons and accounts for an estimated $47 billion in direct and indirect health-care costs (1). Multiple risk factors associated with CHD include genetic susceptibility, elevated serum cholesterol, low levels of high-density lipoprotein cholesterol, cigarette smoking, uncontrolled hypertension, obesity, diabetes mellitus, and physical inactivity (2). This report summarizes information about the potential efficacy and cost-effectiveness of physical activity promotion as a strategy for preventing CHD.
Erratum
Authors: Margarita Beresnevaite, Jean Cottraux, Ivan Note, Eliane Albuisson, Saï Nan Yao, Brigitte Note, Evelyne Mollard, Françoise Bonasse, Isabelle Jalenques, Janine Guérin, André Julien Coudert, C.H. Lücking, Tamás Treuer, Attila Németh, János Füredi, M. Biondi, T. Arcangeli, R.M. Petrucci, Peter E. Sifneos, Thomas N. Wise, Lee S. Mann, Michael J. Sheridan, H.-J. Grabe, S. Rainermann, C. Spitzer, M. Gänsicke, H.J. Freyberger, Satomi Murase, Toshiro Sugiyama, Takashi Ishii, Rie Wakako, Tatsuro Ohta, Thomas Meyer, Heike Klemme, Christoph Herrmann, C.E. Scheidt, E. Waller, H. Malchow, U. Ehlert, F. Becker-Stoll, J. Schulte-Mönting
Journal: Psychotherapy and Psychosomatics (2000)
Meetings of Medical Interest
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Genetic Factors Influencing Irradiation Protection by Bone Marrow. IV. Midlethal Irradiation of F&lt;sub&gt;1&lt;/sub&gt; Hybrid Mice
Journal: JNCI Journal of the National Cancer Institute (1963)

Results from inoculation of allogeneic marrow after midlethal irradiation of various F1 hybrid mice follow essentially the same pattern as those for inbred strains. Early mortality occurs only in mice in which one of the parental strains of the hybrid is C3Hf or CBA.
Prospective, Multicenter Study of the MTOR Inhibitor Everolimus (RAD001) As Primary Therapy in Waldenstrom's Macroglobulinemia
Authors: Steven P Treon, Christina K Tripsas, Leukothea Ioakimidis, Diane Warren, Christopher Patterson, Leonard Heffner, Herbert Eradat, Stephanie A. Gregory, Sheeba Thomas, Ranjana Advani, Rachid Baz, Ashraf Z. Badros, Jeffrey Matous, Kenneth C. Anderson, Irene M. Ghobrial
Journal: Blood (2011)
LETTER FROM NEW YORK.
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 107: Extracellular vesicles from cancer associated fibroblasts induce drug resistance via integrinβ1/FAK signaling in gastric cancer cells
Authors: Tomoyuki Uchihara, Atsuko Yonemura, Keisuke Miyake, Tadahito Yasuda, Rumi Itoyama, Masaaki Iwatsuki, Yoshifumi Baba, Naoya Yoshida, Hideo Baba, Takatsugu Ishimoto
Journal: Cancer Research (2019)

Abstract Background: Cancer-associated fibroblasts (CAFs) enhance tumor progression through secretion of soluble factors. Although we demonstrated that direct-interaction between CAFs and cancer cells confer on gastric cancer (GC) cells the ability to invade extracellular matrix (ECM), the molecular mechanism underlying the drug resistance by soluble factors from CAFs has not been determined. Methods: We have established primary fibroblasts from more than 100 GC patients and collected conditioned medium (CM) of CAFs. Human GC cell lines cultured in normal medium or CAF-CM were examined the drug resistance with or without extracellular matrix (ECM). We isolated extracellular vesicles (EVs) from CAF-CM by ultracentrifugal separation. We performed RNA sequencing of GC cell lines and mass analysis of GC-EVs and CAF-EVs. Results: GC cells treated with CAF-CM or CAF-EVs did not show morphological change on normal coated plates. Notably, we found that GC cells with CAF-CM or CAF-EVs on ECM-coated plates showed unique network formation and cisplatin resistance. Given that the morphological change appeared within 1-3 hours, we predicted that the stimulation by CAF-EV had an impact on the expression pattern of membrane proteins in GC cells. Mass analysis using isolated CAF-EVs was conducted and revealed that CAF-EVs contained high amount of annexin family protein members. Moreover, we showed that annexin in CAF-EVs is critical for network formation and drug resistance of GC cells. Finally, we identified integrinβ1/FAK signaling was activated in GC cells treated with CAF-EVs during network formation. Conclusions: These findings highlight the underlying mechanism whereby CAF-EVs in tumor-microenvironment confer GC cells on drug resistance. Citation Format: Tomoyuki Uchihara, Atsuko Yonemura, Keisuke Miyake, Tadahito Yasuda, Rumi Itoyama, Masaaki Iwatsuki, Yoshifumi Baba, Naoya Yoshida, Hideo Baba, Takatsugu Ishimoto. Extracellular vesicles from cancer associated fibroblasts induce drug resistance via integrinβ1/FAK signaling in gastric cancer cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 107.
Predictive Value
Authors: Neil Skolnik
Journal: Annals of Internal Medicine (2015)

Ad Libitum6 October 2015Predictive ValueNeil Skolnik, MDNeil Skolnik, MDFrom Jenkintown, Pennsylvania.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M15-0226 Audio Reading - “Predictive Value” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Predictive Value," by N. Skolnik. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail (In blessed memory of Jinny Skolnik)I had waited for yearsFor the call:“A spot on the lung,”I was sure they'd say,“She had been coughing,So we ordered the x-ray,”And, then—A hesitation.I rehearsed in my mindHow I'd feelHow many times I'd triedTo convince herTo stop, to give upsmoking. Wasted effort, perhapsBut no effortDone with love is wasted.Then last weekThe call came:Her bone marrow biopsy,Performed after a randomCBC—done for no known reasonShowed low Red cells,White cells, and Platelets:“Acute Myelogenous Leukemia,”The doctor said,Then he continued,“Prognosis: Weeks,Maybe months.”A week later we ... Author, Article, and Disclosure InformationAffiliations: From Jenkintown, Pennsylvania.Current Author Address: Neil Skolnik, MD; e-mail, [email protected]net PreviousarticleNextarticle Advertisement Audio Reading - “Predictive Value” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Predictive Value," by N. Skolnik. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 6 October 2015Volume 163, Issue 7Page: 553KeywordsBiopsyBone marrowCancer chemotherapyCellsChemotherapyCoughingEmotionsLungsMemoryPlatelets ePublished: 6 October 2015 Issue Published: 6 October 2015 Copyright & PermissionsCopyright © 2015 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
P66 Sarcopenia In Copd: Prevalence, Clinical Correlates And Response To Pulmonary Rehabilitation
Authors: S. Jones, M. Maddocks, S. Kon, J. Canavan, C. Nolan, A. Clark, M. Polkey, W.-C. Man
Journal: Thorax (2014)

<h3>Background</h3> Sarcopenia is age-related loss of skeletal muscle mass leading to increased risk of physical disability, poor health status and death. Although sarcopenia is primarily an age-related condition, it is recognised that there are multiple contributing factors, notably from immobility and the effects of chronic disease. International consensus working groups have defined sarcopenia as a loss of muscle mass and reduced muscle strength or function. Although skeletal muscle dysfunction is well recognised in chronic obstructive pulmonary disease (COPD), the prevalence of sarcopenia (defined using international consensus guidelines) and the impact of sarcopenia upon functional capacity and health related quality of life (HRQoL) have not been previously described in patients with COPD. Furthermore, it is not known whether sarcopenia affects the response to pulmonary rehabilitation (PR). <h3>Methods</h3> Sarcopenia was determined using the European Working Group on Sarcopenia in Older People (EWGSOP) algorithm in 622 outpatients with stable COPD. Other measurements included incremental shuttle walk (ISW), five-repetition sit-to-stand (5STS), quadriceps maximum voluntary contraction (QMVC) and HRQoL (St George’s Respiratory Disease (SGRQ) and COPD Assessment Test (CAT)). Response to PR was determined in 43 patients with sarcopenia and compared with a control group identified using propensity score matching. Baseline characteristics and change pre- to post-PR were compared between groups. <h3>Results</h3> Prevalence of sarcopenia was 14.5% (16.1% men and 12.3% women; p = 0.20), which increased with advancing quartiles of age and GOLD spirometric stage. Patients with sarcopenia were older, had worse air flow obstruction, reduced QMVC, exercise capacity and HRQoL (Table 1). Both sarcopenic patients and controls showed significant improvements in exercise capacity, functional performance, QMVC and HRQoL with PR, with no between group differences. Following PR, 12/43 (28%) patients no longer met EWGSOP criteria for sarcopenia. <h3>Conclusion</h3> There is a high prevalence of sarcopenia in patients with COPD which is associated with reduced exercise capacity and HRQoL. Sarcopenia does not impact upon response to pulmonary rehabilitation in COPD.
Future Meetings 2015
Journal: Hepatology (2014)

The overall goal of The Liver Meeting ® is to provide a forum for the exchange of ground breaking research and clinical information in diseases of the liver and biliary tract and in liver transplantation. Target AudienceGroups include clinical hepatologists, gastroenterologists, other health care providers (midlevel providers, internists, pediatricians, family practitioners), and trainees (students, residents, and specialty fellows).The target audience also encompasses scientists studying the development, physiology, pathology, translational medicine, and clinical trials related to the liver and biliary tract and liver transplantation.AASLD takes responsibility for the content, quality, and scientific integrity of this live activity. Learning ObjectivesUpon participation in this live educational activity, learners will be able to:• Incorporate new scientific evidence into clinical care protocols and improve the outcome of adults and children with acute and chronic diseases of the liver and biliary tract.• Establish new collaborations, implement new clinical trials, develop comparative effectiveness projects, and complete investigative efforts that will improve the outcome of adults and children with acute and chronic diseases of the liver and biliary tract.• Implement effective care plans to improve the long-term outcome of the transplanted patient.
MCLA-128 Fights <i>NRG1</i> Fusion–Positive Cancers
Journal: Cancer Discovery (2019)

Abstract Two patients with KRAS–wild-type pancreatic ductal carcinoma and NRG1 fusions received the bispecific antibody MCLA-128, which led to tumor shrinkage. One experienced a partial response and the other had stable disease. A third patient with non–small cell lung cancer and an NRG1 fusion also experienced a partial response in a clinical proof-of-concept study.
Cystic Fibrosis Sweat Test for Newborns
Authors: Warren J. Warwick
Journal: JAMA (1966)

The high incidence of cystic fibrosis in newborn infants, the high mortality in the first year of life if special treatment is not available, and the improvement in mortality when prophylactic pulmonary therapy is added to conventional therapy are the reasons for the urgent search for a sweat test which can be applied routinely to newborn infants. <h3>Incidence</h3> The incidence of cystic fibrosis is unknown, but the estimates<sup>1-9</sup>made in the United States indicate that the true incidence is likely to be between one in 1,000 to 1,400 live-born white infants (Table). The incidence of cystic fibrosis in Negro infants is about 1/9 that in white infants. In comparison with estimates for other congenital or hereditary childhood diseases, cystic fibrosis is about one half as common as mongolism; about as common as club foot, dislocation of the hip, or cleft lip; and about ten times as common as phenylketonuria
Surgically Confirmed Gallbladder Disease, Venous Thromboembolism, and Breast Tumors in Relation to Postmenopausal Estrogen Therapy
Journal: New England Journal of Medicine (1974)

A survey conducted by hospitals in the Boston area of 5339 postmenopausal women for the possible influence of estrogen-containing drugs on gall bladder disease, venous thromboembolism, and breast tumors found gall bladder disease to be the only significantly increased risk (p less than .001). The relative risk for postmenopausal estrogen users was 2.5 (95% confidence interval was from 1.5 to 4.2), and the incidence rate was 131/100,000 women per year. Significant associations between estrogen use and the other diseases were not found.
In This Issue
Journal: American Journal of Psychiatry (2010)

Objective-Evidence suggests that chronic high levels of behavioral inhibition are a precursor of social anxiety disorder (SAD).This study identified the early risk factors for and developmental pathways to chronic high inhibition among school-age children and its association with SAD by adolescence.Method-A community sample of 238 children was followed from birth to Grade 9. Mothers, children, and teachers reported on children's behavioral inhibition from Grades 1 to 9. Lifetime history of psychiatric disorders was available for the subset of 60 (25%) children who participated in an intensive laboratory assessment at Grade 9. Four early risk factors were assessed: female gender; exposure to maternal stress during the infancy and preschool periods and at child age 4.5 years; early manifestation of behavioral inhibition, and elevated afternoon salivary cortisol levels.Results-All four risk factors predicted higher and more chronic inhibition from Grade 1 to Grade 9, and together, defined two developmental pathways.The first pathway in female children was partially mediated by early evidence of behavioral inhibition and elevated cortisol levels at age 4.5 years.The second pathway began with exposure to early maternal stress and was also partially mediated by childhood cortisol levels.By Grade 9, chronic high inhibition was associated with a lifetime history of SAD.Conclusions-Chronic high levels of behavioral inhibition are associated with SAD by adolescence.The identification of two developmental pathways suggests the potential importance of considering both sets of risk factors in developing preventive interventions for SAD.
THE PERCEPTION OF THE BLIND.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Death Denial
Authors: Paul Rousseau
Journal: Journal of Clinical Oncology (2000)

Article Tools THE ART OF ONCOLOGY: WHEN THE TUMOR IS NOT THE TARGET Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2000.18.23.3998 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 11099331 Death Denial Paul RousseauxPaul RousseauSearch for articles by this author Show More From the VA Medical Center and RTA Hospice, Phoenix; Arizona State University, Tempe; and Arizona College of Osteopathic Medicine, Glendale, AZ. https://doi.org/10.1200/JCO.2000.18.23.3998 Full Text PDF Figures and Tables "Death Denial." Journal of Clinical Oncology, 18(23), pp. 3998–3999© 2000 by American Society of Clinical Oncology
'It's over, Debbie' and the euthanasia debate
Authors: G. D. Lundberg
Journal: JAMA (1988)

The apparent act of mercy killing described in "It's Over, Debbie" in the A PIECE OF MY MIND column in the Jan 8,1988, issue of<i>JAMA</i><sup>1</sup>stimulated substantial reaction from the medical profession, the public, the media, and legal authorities. At press time, we have received more than 150 letters. Eighteen examples are published in this issue,<sup>2</sup>as are two representative commentaries.<sup>3,4</sup>Most of the early letters were from physicians and tallied about 4:1 against the action the physician described and 3:1 againstThe JOURNALfor publishing the essay. Reactions from the public and media were delayed but were extraordinary in volume and duration. <h3>Purpose and Process of Publication</h3> We published "It's Over, Debbie" to provoke responsible debate within the medical profession and by the public about euthanasia in the United States in 1988.<sup>5</sup>We believe that<i>JAMA</i>is the right place for issues in American