tbuckley/cabot-search huggingface dataset:
Abstract 1058: Novel Regulation of Wnt-Inducible Secreted Protein 1 by TNF-alpha in Primary Human Cardiac Fibroblasts
Authors: James T Colston, Sam D de la Rosa, Steven R Bailey, Bysani Chandrasekar
Journal: Circulation (2007)

Wnt1-induced secreted protein-1 (WISP-1) is a member of the CCN family of growth factors known to play a role in cellular growth, transformation, and survival. We previously demonstrated that WISP-1 is upregulated in the heart post-infarct, stimulates fibroblast proliferation and collagen expression, and is induced by the proinflammatory cytokine TNF-a. The present study was designed to investigate the molecular mechanisms involved in TNF-a-mediated WISP-1 induction in primary human cardiac fibroblasts (hCF). hCF were treated with rhTNF-a. WISP-1 expression was analyzed by Northern, Western and promoter-reporter assays. ERK1/2 and JNK activations by Western blotting using activation-specific antibodies and imunecomplex kinase assays. CREB activation by Western blotting, EMSA and reporter assay. Results demonstrate that TNF-a potently induces WISP-1 mRNA and protein expression in a time- and dose-dependent manner, effects that were blocked by anti-TNFR2, but not anti-TNFR1, neutralizing antibodies. Further investigations revealed that TNF-a stimulates WISP-1 promoter-reporter activity, an effect that was blunted when the core CREB DNA binding sequence was mutated or following the overexpression of dnCREB. TNF-a treatment induced CREB phosphorylation, in vitro and in vivo DNA binding, and reporter gene activities. TNF-a also induced ERK1/2 phosphorylation and activity, effects that were blocked by the MEK1 inhibitor U0126 and the ERK1/2 inhibitor PD98059. Furthermore, inhibition of ERK1/2 blunted CREB activation while inhibition of ERK1/2 and overexpression of dnCREB attenuated TNF-a-mediated WISP-1 promoter-reporter activity and mRNA expression. However, inhibition of JNK by SP600125 failed to modulate TNF-a-mediated WISP-1 induction. Most importantly, siRNA-mediated WISP-1 knockdown attenuated TNF-a-mediated hCF proliferation. Thus, our results demonstrate for the first time that TNF-a is a potent inducer of WISP1 expression in hCF, and TNF-a induces WISP-1 expression via TNFR2, MEK1, ERK, and CREB. Since TNF-a and WISP-1 are upregulated post-infarct, our results indicate that TNF-a/WISP-1 signaling may play a critical role in post-infarct myocardial remodeling.
Association News
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A phase II study of intermittent sunitinib in previously untreated patients (pts) with metastatic renal cell carcinoma (mRCC).
Authors: Laura S. Wood, Robert Dreicer, Jorge A. Garcia, Timothy D. Gilligan, Khaled B. Ali, Housam Haddad, Shetal N. Shah, Paul Elson, Brian I. Rini
Journal: Journal of Clinical Oncology (2012)

TPS4684 Background: Sunitinib is a standard of care initial treatment in mRCC. One challenge is balancing the acute and chronic toxicity of therapy with clinical benefit. Pre-clinical and retrospective clinical data support the concept that treatment breaks are feasible and not associated with a reduction in efficacy of sunitinib. It is hypothesized that an intermittent dosing regimen of sunitinib in mRCC pts is feasible, and may lead to prolonged duration of disease control with improved tolerance. Methods: Eligibility criteria include treatment-naïve clear cell mRCC, measurable disease, and adequate organ function. Pts will be treated for 4 cycles of sunitinib (50 mg 4/2) in the absence of unacceptable toxicity or RECIST-defined progression. Pts with ≥ 10% reduction in tumor burden per RECIST following 4 cycles will have sunitinib held, with re-staging CT scans approximately every 10 weeks thereafter to assess tumor burden. Sunitinib will be re-initiated in those patients with an increase in tumor burden of 10% or greater (per RECIST) compared to the scan obtained just prior to holding sunitinib. Pts who have RECIST tumor burden reduction of 10% or more compared to scans at the start of the most recent treatment period will again have sunitinib held. This intermittent sunitinib dosing will continue until RECIST-defined disease progression while on sunitinib. Patients not initially achieving at least a 10% reduction in tumor burden will continue sunitinib. The primary objective is the feasibility of intermittent sunitinib, defined as the proportion of patients eligible for and who undergo intermittent therapy. The alternative hypothesis is a feasibility rate of &gt; 80% vs. the null hypothesis of &lt; 50%. Thirty pts provides 80% power based on a two-sided exact test with a .05 type I error. Secondary endpoints include PFS and toxicity. Twenty five of planned 30 patients have been enrolled.
Hepatopulmonary syndrome: Open label trial with allium sativum (garlic) 4. Depts of Internal Medicine, 1Yale University, New Haven, CT; 2Mayo Clinic, Jacksonville, FL. 3LDS Hospital, Salt Lake City, UT and 4University of Alabama, Birmingham, Alabama
Journal: Hepatology (1995)

Previous studies have shown that exercise acutely reduces desire to smoke and withdrawal symptoms among adult smokers; however, no study has examined these effects in younger smokers. This study investigated the impact of a short bout of moderate intensity exercise on desire to smoke, withdrawal symptoms and exercise-induced affect in temporarily abstinent adolescent smokers.Thirty-seven low-active male and female smokers aged 16–19 years, abstained from smoking overnight and were assigned to either (i) 10 min of moderate intensity cycle ergometry (n = 18) or (ii) a placebo control condition that involved very light intensity cycle ergometry (n = 19). Measures of desire to smoke, the Mood and Physical Symptoms Scale (MPSS) and Subjective Exercise Experience Scale (SEES) were administered at baseline, 5 min during, 5 min after and 30 min after both conditions.A significant interaction effect for group by time was recorded for psychological distress scores, when the baseline value was covaried. Follow-up tests indicated that the exercise group reported significantly higher PD scores than the placebo control during exercise, but not at any other time point. No other significant effects were found for any other variables. Unlike research involving adult populations, a short bout of moderate intensity exercise did not alter desire to smoke among abstaining adolescent smokers and may negatively impact affective responses during exercise.
Polk's Medical Register and Directory of the United States and Canada. With Index to the Physicians of the United States Arranged Alphabetically, with the Number of the Page on Which the Name Appears.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Causes of deaths in automobile accidents
Authors: D. F. Huelke
Journal: JAMA (1968)

One hundred and thirty-nine automobile accidents, in which 177 occupants died, were studied over a four-year period. Ejection of the occupant from the car was found to be the leading cause of death. At least 50% of the drivers at fault had been drinking prior to the collision. Collisions at the door caused a significant number of fatalities by collapsing and compromising the passenger compartment. Impacts with the steering assembly and instrument panel ranked high as causes of the fatalities. It is postulated that 40% of those killed could have survived had seat belts been worn and an additional 13%, if seat belts and shoulder belts had been used.
THE SO-CALLED EMBRYONAL GLANDULAR TUMORS OF THE KIDNEY.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BOOK REVIEWS
Authors: E. ZEIGER
Journal: JNCI Journal of the National Cancer Institute (1991)

Journal Article BOOK REVIEWS Get access Mutagens and Carcinogens in the Diet . M.W. Pariza , H.-U. Aeschbacher , J. S. Felton , S. Sato , eds. New York : Wiley-Liss , 1990 , 332 pp. $89.50. ERROL ZEIGER ERROL ZEIGER Mutagenesis Group, National Institute of Environmental, Health Sciences, National Institutes of HealthP. O. Box 12233 Research Triangle Park, NC 27709 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 16, 21 August 1991, Pages 1177–1178, https://doi.org/10.1093/jnci/83.16.1177 Published: 21 August 1991
In Reply
Authors: Patricia A. Ganz, Carol M. Moinpour, Joseph M. Unger
Journal: Journal of Clinical Oncology (2008)

s letter is somewhat unusual in that it asks a number of questions about our publication 1 and interspersed, describes observations of the authors from their own setting.We respond to their queries as follows.Only 33% of the patients in this substudy had received radiation as part of their primary treatment (Table 1 of our article).The sample size for this study was inadequate to compare cardiac event rates among those with radiation and those who did not receive it.Again, the sample size and number of patients receiving radiation was too small to examine this question.In addition, data collection for S8897, the parent treatment study, did not request information about breast cancer laterality.No study of myocardial perfusion abnormalities were made as part of this protocol.However, we did inquire about whether these tests were done, as an indicator of cardiac symptomatology.We did not ask for a report of the clinical findings when such tests were done.We describe in our article the short-and long-term follow-up findings in Table 3.We only found differences in angina in the 5-to 8-year group, but not in any other cardiac event types.We thank Drs Coccaro and Gallucci for their interest in our work.The clinical trial and the follow-up study that we designed were initiated long before there was as much interest in cardiac toxicity as currently.Over time, with the growing number of cancer survivors, understanding the potential risk of treatments (radiation, chemotherapy, biotherapy) for late effects has increased.There is the need for comprehensive prospective studies to examine risks for cardiac toxicity and for monitoring these effects both during and after treatment.We anticipate having better information from treatment evaluation studies that are currently in progress.
Status Report on the Childhood Immunization Initiative: National, State, and Urban Area Vaccination Coverage Levels Among Children Aged 19-35 Months—United States, 1996
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The British Society of Gastroenterology. 1985 spring meeting. Abstracts.
Authors: A Speer, C Leung, P Yin, B Rathbone, S Shires, J Wyatt, B Worsley, L Trejdosiewicz, R Heatley, K Bardtian, G Bianchi Porro, K Bose, Hinciliff Ilazzaroni, P Morris, J Naesdai, A Wai, J Mortensen, J Varma, A Smith
Journal: Gut (1985)

oral or poster presentations included in the scientific sessions are printed below.T4 10 French gauge straight biliary prostheses perform significantly better than 8 French gauge pigtail prostheses
Fiftieth Birthday
Authors: J. R. E.
Journal: Annals of Internal Medicine (1965)

Editorials1 April 1965Fiftieth BirthdayJ. R. E.J. R. E.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-4-841 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe American College of Physicians has just celebrated, at the Golden Anniversary Session in Chicago, its fiftieth birthday. Such a half-century mark is viewed in terms of youthfulness or antiquity, of course, according to the age of the viewer. To the Royal College of Physicians in London, hoary with the antiquity of four and one half centuries, the sister organization in the Western Hemisphere must seem to be a mere infant. But to those members of the American College who worked so hard in the early years to create a similar institution to foster and uphold the highest standards of...References1. PIERSOL GM: Gateway of Honor. The American College of Physicians 1915-1959. Lancaster Press, Lancaster, Pa., 1962, p. 1. Google Scholar2. SPINK WW: Convocation oration: the tradition of the College. Ann. Intern. Med. 61: 147, 1964. LinkGoogle Scholar3. CHURCHILL W: Speech at Royal Albert Hall, September 29, 1943. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1965Volume 62, Issue 4Page: 841-842KeywordsInfants ePublished: 1 December 2008 Issue Published: 1 April 1965 PDF downloadLoading ...
In This Issue
Journal: JAMA Psychiatry (2016)

Psychiatric admissions against the will of the patient can be traumatic and should be prevented.de Jong and colleagues conducted a systematic review and meta-analysis of 13 randomized clinical trials of 4 interventions to reduce compulsory psychiatric admissions: advance statements, community treatment orders, compliance enhancement, and integrated treatment.Advance statements showed a 23% risk reduction in compulsory admissions, but the other 3 treatments did not show a signifi cant risk reduction.In an editorial, Thornicroft and Henderson discuss the importance of reducing compulsory psychiatric admissions.
THE ZEISS OPTICAL WORKS.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prognosis
Authors: Don Thompson
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Radionuclide angiography in the diagnosis of splenic rupture
Authors: F. S. Mishkin
Journal: JAMA (1974)

In two cases of splenic rupture, static radionuclide images of the spleen were normal except for subtle signs of downward displacement. In both, radionuclide angiography clearly delineated an avascular perisplenic process strongly suggesting a hematoma. (<i>JAMA</i>229:1898-1899, 1974)
231P Nomogram to predict prognosis in thoracic esophageal squamous cell carcinoma after neoadjuvant radiotherapy or chemoradiotherapy
Authors: W. Deng, Q. Wang, Z. Xiao, L. Tan, Z. Zhou, H. Zhang, D. Chen, Q. Feng, J. Liang, J. He, S. Gao, K. Sun, G. Cheng, X. Liu, D. Fang, Q. Xue, Y. Mao, D. Wang, J. Li
Journal: Annals of Oncology (2016)
Cavitary pulmonary Hodgkin disease. Association with digital clubbing
Authors: P. Kuritzky
Journal: JAMA (1975)

HODGKIN disease with parenchymal pulmonary involvement as the primary manifestation is uncommon despite the 14% to 40% frequency of pulmonary involvement noted in several autopsy series.<sup>1</sup>Also unusual is the association of digital clubbing with Hodgkin disease. We could find only ten cases reported in the literature.<sup>2-3</sup>We report a case of Hodgkin disease in which both pulmonary cavitation and digital clubbing were the initial findings. To our knowledge, this occurrence has not been described previously. <h3>Report of a Case</h3> In April 1974, a 21-year-old woman was admitted to Millard Fillmore Hospital for treatment of a cavitary process in the right lung. Eight months before admission, she had noted generalized pruritus and amenorrhea. Three months later, a persistent cough developed, and she was treated with tetracycline. Hemoptysis occurred, and the patient's weight fell from 47.7 to 40.9 kg (105 to 90 lb). Two months before admission she entered