tbuckley/cabot-search huggingface dataset:
FOOTBALL AND ITS DANGERS.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Evidence for neurological dysfunction in end-stage protoporphyric liver disease
Authors: J Rank
Journal: Hepatology (1993)

Protoporphyria is a genetic disorder characterized by a defect in the enzyme ferrochelatase, which catalyzes the chelation of iron to protoporphyrin. This causes excessive accumulation and excretion of protoporphyrin. The predominant clinical feature is photosensitivity. Progressive and fatal liver disease occurs in a small percentage of cases. We report our experience with eight patients with end-stage protoporphyric liver disease in whom a syndrome developed before transplantation that resembled the neurological crises of the acute porphyrias. This syndrome was characterized by abdominal pain, hypertension, tachycardia, extremity pain and weakness, constipation and nausea and vomiting. Erythrocyte and serum protoporphyrin levels were markedly increased in all patients. In one patient, profound hemolysis developed during the anhepatic phase of transplantation and continued over a period of 72 hr, causing an extreme increase in the serum protoporphyrin level. Progressive weakness deteriorated to paralysis in this patient. This phenomenon suggests that protoporphyrin may gain access to neural tissue when serum levels are markedly increased, causing neurotoxicity. (HEPATOLOGY 1993;18:1404–1409.)
THE ABUSE OF CLIMATIC TREATMENT OF TUBERCULOSIS.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Social barriers faced by adolescent parents and their children
Authors: H. Spivak
Journal: JAMA (1987)

Pregnancy and childbearing are well recognized as having significant, long-term consequences for teenagers. Recent literature documents an array of negative outcomes for children born to adolescents, with a range of factors identified as contributing to the problems observed in these children. These include (1) the characteristics of those teenagers most likely to become parents, (2) the social and economic consequences of early childbearing, (3) the increased biologic vulnerability of children born to teenagers, and (4) the nature of parenting by teenagers. It has been acknowledged that adolescent parents tend to come from high-risk families, have poor academic achievement, and live in our most disadvantaged communities and therefore, biologic, economic, and behavioral factors contribute to the increased likelihood of teenagers having children who are vulnerable to physical and developmental problems. Teenaged parents face many obstacles to economic and social success, and these further influence the environment in which their children grow up. Adolescents also experience many difficulties in adjusting to parenthood and display a range of suboptimal parenting practices. Whereas some of these factors appear highly resistant to change, others have clear clinical, programmatic, and policy implications. (<i>JAMA</i>1987;258:1500-1504)
Minimal Residual Disease Tests Provide an Independent Predictor of Clinical Outcome in Adult Acute Lymphoblastic Leukemia
Authors: Forida Y. Mortuza, Mary Papaioannou, Ilidia M. Moreira, Luke A. Coyle, Paula Gameiro, Domenica Gandini, H. Grant Prentice, Anthony Goldstone, A. Victor Hoffbrand, Letizia Foroni
Journal: Journal of Clinical Oncology (2002)

PURPOSE: Investigation of minimal residual disease (MRD) in childhood acute lymphoblastic leukemia (ALL) using molecular markers has proven superior to other standard criteria (age, sex, and WBC) in distinguishing patients at high, intermediate, and low risk of relapse. The aim of our study was to determine whether MRD investigation is valuable in predicting outcome in Philadelphia-negative adult patients with ALL. PATIENTS AND METHODS: MRD was assessed in 85 adult patients with B-lineage ALL by semiquantitative immunoglobulin H gene analysis on bone marrow samples collected during four time bands in the first 24 months of treatment. Fifty patients received chemotherapy only and 35 patients received allogeneic (n = 19) or autologous (n = 16) bone marrow transplantation (BMT) in first clinical remission. The relationship between MRD status and clinical outcome was investigated and compared with age, sex, immunophenotype, and presenting WBC count. RESULTS: Fisher’s exact test established a statistically significant concordance between MRD results and clinical outcome at all times. Disease-free survival (DFS) rates for MRD-positive and -negative patients and log-rank testing established that MRD positivity was associated with increased relapse rates at all times (P &lt; .05) but was most significant at 3 to 5 months after induction and beyond. MRD status after allogeneic BMT rather than before was found to be an important predictor of outcome in 19 adult patients with ALL tested. In patients receiving autologous BMT (n = 16), the MRD status before BMT was more significant (P = .005). CONCLUSION: The association of MRD test results and DFS was independent of and greater than other standard predictors of outcome and is therefore important in determining treatment for individual patients.
Genetic Predispositions and Childhood Cancer
Authors: Kevin Shannon
Journal: Environmental Health Perspectives (1998)

This article provides an overview of the problem of genetic susceptibility to childhood cancer with a particular emphasis on problems with ascertaining inherited cancer risk and the role of tumor-suppressor gene mutations in cancer predispositions.The association between neurofibromatosis type 1 and childhood leukemia is used to illustrate some of the issues faced by molecular biologists and genetic epidemiologists in identifying and analyzing at-risk individuals.The problem of incomplete penetrance in cancer susceptibility is presented and potential models are discussed.The article concludes with a number of tentative conclusions from existing data and speculations for future studies.
Aldosteronism in Hypertension: Spironolactone Response Test.
Authors: Richard F. Spark
Journal: Annals of Internal Medicine (1968)

s1 May 1968Aldosteronism in Hypertension: Spironolactone Response Test.Richard F. Spark, M.D., James C. Melby, M.D.Richard F. Spark, M.D.Search for more papers by this author, James C. Melby, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-68-5-1162_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe demonstration of low plasma renin activity (PRA) and increased aldoestrone secretory rate (ASR) may not be sufficient to distinguish primary aldosteronism due to an aldosterone secretory adenoma from secondary aldosteronism associated with renovascular and accelerated hypertension. Since aldosterone hypersecretion is responsible for the hypertension in primary aldosteronism and is not causative in secondary aldosteronism, antagonism of aldosterone action by spironolactone should relieve hypertension only in primary aldosteronism. Response to spironolactone given in high dose (400 mg/day) for 3 to 5 weeks to 42 patients with elevated ASR and hypertension was as follows:Serum electrolyte abnormalities were corrected in both... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1968Volume 68, Issue 5Page: 1162-1163KeywordsAdenomasAldosteroneHypertensionPlasma renin activity Issue Published: 1 May 1968 PDF DownloadLoading ...
The Practice of Surgery.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Voices in the Wilderness
Journal: Environmental Health Perspectives (1993)

Until recently, says Plewa, the litera- ture in this area has suggested that bound residues exhibit little bioavailability when consumed by animals, so the "traditional idea is don't worry about them; it can't hurt you."However, recent studies dem- onstrated that scientists may be severely underestimating the bioavailability of these residues, with implications for risk assess- ment.Studies published in the Journal of Agricultural and Food Chemistry showed 66% of chloroaniline (a model xenobiot- ic)-lignin metabolites were released as simple chloroaniline derivatives after passage through the rat gastrointestinal tract, and 11-20% of bound residues was released from 3,4-dichloroaniline-lignin isolated from wheat plants that were fed to rats and lambs.According to Plewa, these studies indicate that "the toxicity [of the metabo- lite] could be released.It isn't just tied up and disappears."There appears to be a wide range in the bioavailability of xenobi- otics bound to insoluble plant fractions.This range in bioavailability raises questions that may have great impact in the future for environmental toxicology.Plewa says that plants are being bombard- ed with materials.What isn't known is the capacity of plants to serve as a sink.Is it possible to saturate this sink so that plants cannot further absorb and metabolize chemicals to stable, insoluble forms, and if so, will plants then release what they can't absorb, damaging the biosphere?In addi- tion, Plewa states that if current risk assessments are based on the amount of residue that is not bound, then a change in that estimate could have a radical effect: "You don't need to alter too much of the equa- tion before it shifts the risk assessment."
Percutaneous Coronary Intervention vs Thrombolysis for ST-Elevation Myocardial Infarction
Authors: Jacek Legutko, Zbigniew Siudak, Dariusz Dudek, Lukasz Rzeszutko
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Transaminase levels in acute pancreatitis and after secretin stimulation. Preliminary study
Authors: W. M. Lukash
Journal: JAMA (1966)

SERUM transaminase levels have been reported to be elevated in pancreatitis, but the elevations are usually seen in icteric patients and probably reflect liver and biliary disease. The enzymes, serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT), are found in various tissues. Wroblewski and LaDue<sup>1</sup>established the levels of transaminase activity in homogenates of different human tissues and observed a level of concentration in the pancreas equal to 20% of that found in the liver. Diseases involving tissue containing these enzymes are thought to cause elevation of serum levels. On this basis, Foulk and Fleisher<sup>2</sup>studied 32 patients during episodes of pancreatitis. Transaminase activity was increased in 22 of these patients. They concluded, however, that increased transaminase activity is not entirely dependent on pancreatic necrosis, but related to increased intrabiliary pressure and associated obstruction of the biliary tract. Weinstein et al<sup>3</sup>further emphasized the
Effects of Chronic Arsenic Exposure on Hematopoietic Function in Adult Mammalian Liver
Authors: James S. Woods, Bruce A. Fowler
Journal: Environmental Health Perspectives (1977)

In these studies the effects of ingested arsenic (As+5) on hepatic heme biosynthetic capability and hemoprotein function in adult male rats were investigated. Animals exposed for 6 weeks to 0, 20, 40, or 85 ppm sodium arsenate in the drinking water suffered depression of hepatic δ-aminolevulinic acid (ALA) synthetase and heme synthetase (ferrochelatase) activities, with maximal decreases to 67 and 55% of control levels, respectively, at 85 ppm. Concomitantly, urinary uroporphyrin levels were elevated by as much as 12 times, and coproporphyrin by as much as 9 times, control values. The rate of incorporation of 3H-ALA into mitochondrial and microsomal hemes was depressed by 40–50% at 20 ppm but was increased with regard to controls by as much as 150% at the higher treatment levels. A similar biphasic pattern was observed in regard to 14C-leucine incorporation into cellular membranal proteins. In contrast, the levels of ALA dehydratase, uroporphyrinogen I synthetase, aminopyrine demethylase, and cytochrome P-450 were not significantly changed in As+5-treated rats. These results support the hypothesis that chronic, low level, arsenic exposure results in selective inhibition of mitochondrial-bound heme biosynthetic pathway enzymes (ALA synthetase and heme synthetase) resulting in a substantial increase in urinary porphyrins, uniquely characterized by a greater increase in uroporphyrin than coproporphyrin levels. These changes occur independent of, or prior to, alterations in hepatic hemoprotein-dependent functions and may thus serve in the clinical analysis of pretoxic exposure to arsenic compounds in human populations.
Operative Thorakoskopie.
Journal: JAMA (1953)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
What are the Conditions for Retaining Permanent Membership in the American Medical Association?
Journal: JAMA (1884)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Studies on Primary Hyperoxaluria: I. In Vivo Demonstration of a Defect in Glyoxylate Metabolism
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cardiopulmonary Resuscitation
Authors: Gregory Burke
Journal: JAMA (1993)

<h3>To the Editor.</h3> —We would like to advise you of an inappropriate recommendation concerning management of the pediatric airway. During a discussion of percutaneous needle cricothyrotomy for patients with severe facial trauma in the section "Miscellaneous Adjuncts to Airway Ventilation,"<sup>1</sup>the use of a largebore (ie, 14-gauge) over-the-needle catheter attached to a standard (3-mm) endotracheal tube adapter and a hand resuscitation bag is recommended. There is an unreferenced statement, "This technique enables effective support of oxgenation." We believe that there is no evidence to support the effectiveness of this recommendation. In fact, there is significant published material suggesting that this technique will not support oxygenation and ventilation. In 1988, Yealy et al<sup>2</sup>demonstrated that ventilation through a catheter with a bagvalve setup is not effective unless one is using a minimal tube size of 3.5-mm internal diameter (ID).<sup>2</sup>Furthermore, these authors confirmed that if one uses a
CHRONIC PANCREATITIS
Authors: Jas. H. Nicoll
Journal: BMJ (1920)

rTHU RI TZwU I K= Jousw* that lie died of starvation owing to want of the five pounds, and left no leir.Substitute in my apologue "reaction " for "debt" and "painful stimulus "-or any otlher polysyllabic equivalent you please-for "creditor," and one is close enough for practical purposes to the topic under discussion.How are we to decide 'whether (1) or ( 2) is the-better
Congenital annular bands (pseudoainhum). Associtaion with other congenital abnormalities
Authors: A. K. Izumi
Journal: JAMA (1974)

Congenital annular bands are developmental anomalies in which hyperplastic collagen nearly replaces the subcutaneous tissue. In more than half of reported cases, they are accompanied by other mesenchymal anomalies, particularly syndactyly and clubfoot. The common embryologic derivation of these anomalies suggests a basic mesenchymal developmental defect. (<i>JAMA</i>229:1208-1209, 1974)