tbuckley/cabot-search huggingface dataset:
Aortoplasty in Infants with Coarctation
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Stimulus Properties of Inhaled Substances
Authors: Ronald W. Wood
Journal: Environmental Health Perspectives (1978)

Inhaled substances can modify behavior by their toxic action, or because they are discriminable events, or because they can support or suppress behavior. They can be used as discriminative stimuli at concentrations above the olfactory threshold. Inhalants can elicit unconditioned reflexes. As aversive stimuli, they can be studied in respondent conditioning experiments (e.g. conditioned suppression), in punishment paradigms, or as negative reinforcers in escape paradigms. Inhalants can also be positive reinforcers; their intoxicating properties have engendered patterns of chronic self-administration (solvent abuse). Such stimulus properties should be considered in industrial hygiene and environmental quality decisions. Laboratory techniques to study such properties abound.
American Journal of Surgery, New York
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Physicians and disaster preparedness
Authors: J. O. Mason
Journal: JAMA (1992)

<h3>To the Editor.</h3> —I was delighted to see the focus on national planning for medical response to major disasters and emergencies.<sup>1</sup>However, in reading the article, I was disappointed to discover that Drs Pretto and Safar failed to recognize the important distinction between traditional, everyday emergency medical services (EMS) response and catastrophic mass casualty response. In fact, they completely ignored the National Disaster Medical System (NDMS), its current operational plans and arrangements, and its rapidly increasing medical response capabilities. Although EMS deal with everyday emergencies, a disaster, by definition, is an occurrence that overwhelms available personnel and other resources. To assume that concentrations of personnel and technology will occur rapidly following an incident producing tens of thousands of seriously injured or ill victims is impractical and unrealistic and creates false expections. Given the vast geographic area of our nation, the multiple major metropolitan concentrations of our population, the wide
Fetal erythrocytes in maternal circulation after spontaneous abortion
Authors: O. Litwak
Journal: JAMA (1970)

Transplacental passage of fetal erythrocytes occurs in 32% of patients undergoing spontaneous abortion. Intrauterine instrumentation for incomplete abortion favors the placental passage of larger volumes of fetal cells. The relationship of isoimmunization to transplacental hemorrhage, although clearly established in term pregnancies, remains to be elucidated after abortion. Because of the unknown risk of sensitization from this cause, and since 26% of our patients show evidence of transplacental hemorrhage of 0.05 ml or more, the practice of administering anti-Rho γ-globulin after abortion in an Rh-negative patient seems indicated. We suggest that early isoimmunization, and thus apparent subsequent failures in Rh prophylaxis, may be caused by a large fetal hemorrhage which occurs during pregnancy after threatened abortion.
RECENT COURT DECISIONS REGARDING IMPRISONMENT OF ALCOHOLICS
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Comprehensive Gynecology
Authors: Ronald T. Burkman
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE SCOPE OF STATE SANATORIA.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Soliloquy
Authors: John L. Wright
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BOOK REVIEWS
Authors: G. S. OMENN
Journal: JNCI Journal of the National Cancer Institute (1989)

BOOK REVIEWS Get access Advances in Cancer Control: Innovations and Research. Paul N. Anderson, Paul F. Engstrom, Lee E. Mortenson, eds. New York: Alan R. Liss, Inc., 1989, 407 pp. $84. GILBERT S. OMENN GILBERT S. OMENN Public Health and Community Medicine University of Washington1959 N.E. Pacific St. Seattle, WA 98195 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 81, Issue 22, 15 November 1989, Pages 1748–1749, https://doi.org/10.1093/jnci/81.22.1748 Published: 15 November 1989
Hotel-Dieu: Cure of Chlorosis by Iron
Journal: BMJ (1842)

When the fistula is small, it often heals up sponta- neously; if a little larger, mulch benefit will be derived from the employment of the actual cautery, but the present mode of applying this remedy is faulty.The tumefaction of the edges of the fistula, caused by the cautery, closes the opening for a few days; but the
Phosphodiesterase-5 is Highly Expressed in the Hypertrophied Human Right Ventricle and Acute Inhibition Causes Increased Contractility via cGMP-Inhibition of Phosphodiesterase-3
Authors: Jayan Nagendran
Journal: Circulation (2007)

Abstract 278 Jayan Nagendran, Stephen L Archer, Daniel Soliman, Vikram Gurtu, Al Haromy, Ivan M Rebeyka, David B Ross, Peter E Light, Evangelos D Michelakis, University of Alberta Hosp, Edmonton, AB, Canada Jayan Nagendran, 2007 Finalist and Presenting Author
Reduced Transplant Lung Volumes after Single Lung Transplantation for Chronic Obstructive Pulmonary Disease
Authors: Abraham F. Cheriyan, Edward R. Garrity, Roque Pifarre, Patrick J. Fahey, John M. Walsh
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

Single lung transplantation is now an extremely successful option for the treatment of end-stage chronic obstructive pulmonary disease (COPD). This procedure involves placing a normal sized lung in a hyperinflated hemithorax. Preliminary observations of these patients suggest that the transplanted lung volume is smaller than expected and often the native (COPD) lung increases in volume. The purpose of this investigation was to quantify the volume contributions of the transplant and native lung to the total lung capacity. In seven patients who underwent single lung transplant for end-stage COPD the transplant and native lung volumes were measured by computer-analyzed planimetry immediately after transplant and the following 6 mo post-transplant. The transplant lung volume was smaller than predicted immediately after transplant at only 33 ± 5% (mean ± SD) of predicted TLC. This did not change significantly over the next 6 mo. Native lung volume increased following transplant to 74 ± 19% predicted TLC at 1 mo and 80 ± 16% at 6 mo. Five of the seven patients subsequently underwent measurement of pleural pressures at TLC. The mean static pleural pressure at TLC was low at −16 ± 5.1 cm H2O. In summary, following single lung transplantation for COPD the transplanted lung is significantly restricted. We conclude that the likely mechanism of this restriction is due to low transpulmonary pressure generation.
05.11 Antisense long noncoding rnas are deregulated in skin tissue of ssc patients
Authors: Tobias Messemaker, Loubna Chadli, Varshna Goelela, Maaike Boonstra, Annemarie Dorjee, Stefan Andersen, Harald Mikkers, Oliver Distler, Tom Huizinga, Zhenghui Li, Guoshuai Cai, Michael Whitfield, Rene Toes, Jamil Aarbiou, Jeroen de Groot, Jeska De Vries-Bouwstra, Fina Kurreeman
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Systemic sclerosis (SSc) is an autoimmune disease characterised by fibrosis of skin and multiple organs of which pathogenesis is poorly understood. Here we studied differentially expressed coding and non-coding genes in relation to SSc pathogenesis with a specific focus on antisense non-coding RNAs. <h3>Materials and methods</h3> Skin biopsy-derived RNAs from fourteen early SSc patients and six healthy individuals were sequenced with ion-torrent and analysed using DEseq2. Protein-coding and non-coding genes annotated in GENCODEV7 were analysed. Significant long non-coding RNAs were independently replicated in a Northern American dataset. <h3>Results</h3> 4901 genes with a fold change &gt;1.5 and a false discovery rate of less than 5% were detected in patients versus controls. Upregulated coding genes clustered in immunological, cell adhesion and keratin-related processes as previously found by microarray studies. Interestingly, 676 deregulated non-coding genes were detected, 257 of which were classified as antisense genes. 42% of these antisense genes had a concurrent deregulated sense gene. The majority of the sense-antisense genes had a similar effect sizes in an independent North American dataset with three genes (OTUD6B-AS1, CTBP1-AS2 and HMGN3-AS1) exceeding the study-wide Bonferroni-corrected ρ-value (P<sub>Bonf</sub> &lt;0.0024, P<sub>combined</sub>=1.6×10<sup>-9</sup>, 1.7 × 10<sup>–6</sup>, 2.6 × 10<sup>–6</sup>, respectively). Intriguingly, the correlation of sense-antisense gene pairs deregulated in SSc is stronger than sense-antisense gene pairs not deregulated in SSc (p&lt;0.001). <h3>Conclusions</h3> For the first time we highlight that together with coding genes, (antisense) long noncoding RNAs are deregulated in skin tissue of SSc patients suggesting a novel class of genes involved in pathogenesis of SSc.
The Apolipoprotein E E4 Allele and Sex-Specific Risk of Alzheimer's Disease-Reply
Authors: Haydeh Payami
Journal: JAMA (1995)

<h3>In Reply.</h3> —We originally reported data on late-onset familial AD that showed a significantly (<i>P</i>=.004) higher risk for women with one apo E<i>E4</i>allele than for men with one<i>E4</i>allele. In their letter, Dr Corder and colleagues report no significant difference between men and women in their late-onset familial and sporadic AD data. Lack of evidence in sporadic AD is not surprising; we had suspected that the gender difference may be present only in the familial cases. However, it is puzzling that they did not find the same strong gender difference that we did in the familial cases. According to Figures 1 and 2 of their letter, by 85 years of age nearly 100% of women with one<i>E4</i>allele were affected as compared with 50% of men with one<i>E4</i>allele, but the overall difference was not statistically significant (<i>P</i>=.12), possibly indicative of small sample
Grundriss der inneren Medizin.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Manuscripts Approved for JNCI, November 15 to December 15, 1959
Journal: JNCI Journal of the National Cancer Institute (1960)

Journal Article Manuscripts Approved for JNCI, November 15 to December 15, 1959 Get access JNCI: Journal of the National Cancer Institute, Volume 24, Issue 1, January 1960, Page 253, https://doi.org/10.1093/jnci/24.1.253 Published: 01 January 1960
One-stage replantation of both lungs in the dog
Authors: F. Alican
Journal: JAMA (1971)

In clinical lung allotransplantation, the recipient's remaining diseased lung has caused severe ventilation perfusion imbalance in the graft. We have performed one-stage bilateral lung replantation on 26 dogs as a prototype for possible future solution of this physiologic problem. Pulmonary edema was the main cause of death. Ten dogs lived more than 1 month after operation; seven are still alive and vigorous up to 6 1/2 months. X-ray films of the chest, pulmonary arterial pressures, angiograms, and blood gas levels are normal. Conclusions are that (1) pulmonary edema is proportional in severity to the degree of anoxic damage to the graft, and is potentially reversible; (2) one-stage total pulmonary denervation is readily tolerated by the dog; and (3) simultaneous bilateral lung replantation with long-term survival and nearly normal dynamics of ventilation and pulmonary circulation is feasible.
Authors' reply
Authors: S G Wright, P L Chiodini
Journal: BMJ (1996)

We address the challenge of inferring a consensus 3D model of genome architecture from Hi-C data. Existing approaches most often rely on a two step algorithm: first convert the contact counts into distances, then optimize an objective function akin to multidimensional scaling (MDS) to infer a 3D model. Other approaches use a maximum likelihood approach, modeling the contact counts between two loci as a Poisson random variable whose intensity is a decreasing function of the distance between them. However, a Poisson model of contact counts implies that the variance of the data is equal to the mean, a relationship that is often too restrictive to properly model count data. We first confirm the presence of overdispersion in several real Hi-C data sets, and we show that the overdispersion arises even in simulated data sets. We then propose a new model, called Pastis-NB, where we replace the Poisson model of contact counts by a negative binomial one, which is parametrized by a mean and a separate dispersion parameter. The dispersion parameter allows the variance to be adjusted independently from the mean, thus better modeling overdispersed data. We compare the results of Pastis-NB to those of several previously published algorithms: three MDS-based methods (ShRec3D, ChromSDE, and Pastis-MDS) and a statistical methods based on a Poisson model of the data (Pastis-PM). We show that the negative binomial inference yields more accurate structures on simulated data, and more robust structures than other models across real Hi-C replicates and across different resolutions. A Python implementation of Pastis-NB is available at https://github.com/hiclib/pastis under the BSD license Supplementary information is available at https://nellev.github.io/pastisnb/
UNILATERAL EXOPHTHALMOS
Authors: E. C. ELLETT
Journal: JAMA (1941)

Exophthalmos or proptosis is usually considered, and rightly so, to be due to something in the orbit pushing the eye forward. Only a careless observer would confuse the different conditions in which the eye itself is enlarged, e. g. buphthalmos, with the protrusion of a normal eye, or at least a normal sized eye, in advance of its normal or natural position. The "something," i. e. the cause of the exophthalmos, may be one of a variety of things, and some of them and what is best to do for them will be briefly considered. Instruments to measure the protrusion have been devised, so that one does not have to depend on the sense of sight or touch to know when an eye protrudes beyond its fellow. The best known instrument is the Hertel exophthalmometer, a satisfactory instrument though somewhat difficult to use. It must be carefully applied to the
Coronary-prone individuals (type A behavior pattern. Some biochemical characteristics
Authors: M. Friedman
Journal: JAMA (1970)

Studies of the plasma triglyceride, free fatty acids, cholesterol, glucose, uric acid, cortisol, insulin, growth hormone, and thyroxine values of relatively "coronary-prone" (behavior type A) and relatively coronary "resistant" (behavior type B) subjects were performed. The group of coronary-prone subjects not only exhibited abnormally high plasma triglyceride (both before and after fat feeding) and cholesterol values but also a hyperinsulinemic response to a glucose challenge. There was also suggestive evidence of a decreased content of growth hormone in the plasma of the same coronary-prone subjects. Plasma levels of free fatty acids, uric acid, glucose, cortisol, and thyroxine, however, were not elevated in these same subjects.