tbuckley/cabot-search huggingface dataset:
Nordisk Medicin, Stockholm
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
From the Assistant Secretary for Health
Authors: Robert E. Windom
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clozapine treatment of schizophrenia
Authors: D. Pickar
Journal: JAMA (1995)

<h3>SELECTED CASE</h3> A 27-year-old woman was admitted to the National Institutes of Health Clinical Center, Bethesda, Md, for inpatient research protocol for schizophrenia. She first experienced behavioral disturbances at 13 years of age when she became withdrawn and isolated from friends and family. She reported auditory hallucinations for the first time at 16 years and developed delusions of control and persecution over ensuing months. Suicidal ruminations culminated in a serious suicide attempt and her first hospitalization at the age of 17 years. Although standard antipsychotic drugs reduced her delusions, the patient remained socially isolated and had symptom exacerbation when under stress. She discontinued antipsychotic drug treatment because of adverse effects on several occasions; in each case, she became acutely psychotic. Prior to her admission to the National Institute of Mental Health, she was hospitalized 15 times, including several hospitalizations mandated by the court because of risk to herself and to
Mechanisms of Multistep Carcinogenesis and Carcinogen Risk Assessment
Authors: J. Carl Barrett
Journal: Environmental Health Perspectives (1993)

Many different types of chemical exposures can increase the incidence of tumors in animals and humans, but usually a long period of time is required before the carcinogenic risk of an exposure is manifested. Both of these observations can be explained by a multistep/multigene model of carcinogenesis. In this model, a normal cell evolves into a cancer cell as the result of heritable changes in multiple, independent genes. The two-stage model of initiation and promotion for chemical carcinogenesis has provided a paradigm by which chemicals can act by qualitatively different mechanisms, but the process of carcinogenesis is now recognized as more complex than simply initiation and promotion. Even a three-stage model of initiation, promotion, and progression, which can be operationally defined, is not adequate to describe the carcinogenic process. The number of genes altered in a cancer cell compared to a normal cell is not known; recent evidence suggests that 3-10 genetic events are involved in common adult malignancies in humans. Two distinct classes of genes, protooncogenes and tumor-suppressor genes, are involved in the cancer process. Multiple oncogenes may be activated in a tumor, while multiple tumor-suppressor genes may be inactivated. Identification of the genes involved in carcinogenesis and elucidation of the mechanisms of their activation or inactivation allows a better understanding of how chemical carcinogens influence the process of neoplastic evolution. The findings of multiple genetic changes (including point mutations, chromosomal translocations, deletions, gene amplification, and numerical chromosome changes) in activated protooncogenes and inactivated tumor-suppressor genes provide experimental support for Boveri's somatic mutation theory of carcinogenesis. In addition to mutagenic mechanisms, chemicals may heritably alter cells by epigenetic mechanisms and enhance the clonal expansion of altered cells. Most chemical carcinogens operate via a combination of mechanisms, and even their primary mechanism of action may vary depending on the target tissues. The classification of chemicals by mechanism of action or by nongenotoxic or genotoxic activity has certain inherent difficulties because no classification of chemicals is exhaustive or definitive.
The relation between post-systolic shortening and residual viable myocardium after acute myocardial infarction: A comparison of strain rate imaging with magnetic resonance tomography and scintigraphy Jens-Uwe Voigt, Matthias Regenfus, Gerd Lindenmeier, Christian Schlundt, Uwe Nixdorff, Frank A. Flachskampf, Werner G. Daniel. University Erlangen, Erlangen, Germany
Journal: Journal of the American College of Cardiology (2001)
The medical expert witness in malpractice suits
Authors: P. C. Bucy
Journal: JAMA (1975)

THE COURTROOM is alien country to many physicians, and the behavior of lawyers incomprehensible. A subpoena to serve as a witness or the request to be an expert witness strikes fear into the hearts of many physicians. Some have a mental picture of cross-examination comparable to an inquisition. "He will attempt to demonstrate my ignorance." "He will cast unfavorable reflection on my integrity and my motives." "He is not in search of the truth. He is only out to win a case." To varying degrees, these fears may be justified, but they should not prevent the physician from serving as a witness when he is needed, nor should he feel intimidated to the point where he is not able to collect his thoughts and express himself adequately. At the outset, it is important that the physician have a clear picture of his situation. He is in the unusual position, for
Die Dickdarmschleimhaut, ihre normale und pathologische Funktion im Röntgenbilde.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The epidemiologic necropsy
Journal: JAMA (1987)

<h3>To the Editor.—</h3> The July 17, 1987, issue of<i>JAMA</i>contained an article by Kircher and Anderson<sup>1</sup>concerning the proper completion of the death certificate. The dissemination of this information is long overdue and the authors are to be commended. However, their choice of examples to illustrate accurate death certification in trauma victims would have been more causally specific if the authors had not included "automobile accident" and "slipped and fell in bathtub" in the cause of death section. In our view, the authors have mixed etiology and manner of death with the cause of death, which should reflect either a disease or injury. This could have been avoided with a more appropriate choice of proximate cause. The appropriate proximate cause in both of these instances is "blunt impact" or "blunt force" to the specified body area. The authors listed "automobile accident" and "slipped and fell in bathtub" as the
Childbed Fever
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Elimination of the Hazards from Hazardous Wastes
Authors: Earnest F. Gloyna, Ronald D. Taylor
Journal: Environmental Health Perspectives (1978)

The "hazard" associated with a waste essentially controls the overall engineering approach to finding suitable alternatives for solving potential disposal problems. It should be recognized that all factors affecting environmental equilibrium must be considered, including product sales, process design, financing, pre- and end-of-pipe treatment, residuals management, and ultimate bioaccumulation of residuals. To meet this challenge, a systems approach to waste treatment and residuals disposal provides a logical approach, but this management concept requires a thorough understanding of the important physical and chemical aspects of the problem, as well as many social implications of the resulting decisions. Thus waste management within a plant necessarily involves process control, pretreatment and end-of-pipe treatment. Further, it follows that residuals management from a disposal point-of-view must ultimately embrace what is called the "multi-barrier concept." In essence, hazard elimination occurs in varying degrees during each phase of a properly engineered system.
MENTAL HEALTH IN WAR TIME
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Determination of body mass index
Authors: H. M. Frankel
Journal: JAMA (1986)

<h3>To the Editor.—</h3> I found myself heartily agreeing with Dr Glew<sup>1</sup>in his assessment of the use of double negative construction. I could not believe my eyes when I got to QUESTIONS AND ANSWERS<sup>2</sup>in the same issue. In answer to question 2, the third paragraph began, "Not all nonunions are not painful nor..." This one looks like a triple negative shooting for quadruple!
Myocardial Infarction in a Child with Primary Thrombocytosis
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Using evidence on yourself
Authors: Richard Smith, Jane Smith, Annabel Ferriman, Linda Beecham, Sandra Goldbeck-Wood, Alison Tonks General, Trish Groves, Kamran Abbasi, Tessa Richards, Sharon Davies, Liz Crossan, Obituaries Linda, Beecham Reviews, Douglas Carnall, Gaby Shockley, Margaret Benfell, Andrew Woodward, John Gary, Bryan Standing, Gavin Yamey, Susan Minns, Marita Batten Picture, Jan Science, Abi Berger, Margaret Cooter, Jackie Annis, Greg Cotton, Liz Payne, Miriam Pinchuk, Julia Thompson, Tony Delamothe, Christopher Martyn, Marcus Müllner, Roger Robinson, Tony North, Ron Davis, Jennifer Leaning, Rajendra Kale, John Roberts, Gwen Adshead, James Barrett, Nick Booth, Nicky Britten, Peter Cantillon, Angela Coulter, Teifion Davies, Robin Ferner, Ian Forgacs, Trisha Greenhalgh, Marcia Hall, Iona Heath, Richard Hobbs, Linda Hutchinson, David Jewell, Kevin Jones, Duncan Keeley, Tim Lancaster, Ben Lloyd, Diana Lockwood, Azeem Majeed, Michael O'brien, John Rees, Nicholas Steel, Sheila Teasdale, Tom Treasure, Chris Van Weel, John Williams, Diana Wood, Jeremy Wyatt, Doug Altman, Mike Campbell, Tim Cole, Jon Deeks, Stephen Evans, David Machin, Julie Morris, Jackie Connor, Andy Josephides, Bernadette Kearney, Catherine Harding-Wiltshire, Steve Mcauley, Simon Walker, Sheila Rowe, David Evans, Jeremy Anderson, Nicholas Christakis, Luis-Gabriel Cuervo, Tony Culyer, Michael Dixon, Paul Glasziou, Heather Australia, Roger Goodare, Peter Goss, Tony Denmark, Brian Grabham, Canada Haynes, Christian Knottnerus, Cindy Austria, Hong Lam, Leonard Kong, Israel Lebovici, Michel Liberati, France Lievre, Claude Jean, Cynthia Cameroon, Gretchen Purcell, Lois Quam, Paula Rochon, Canada Sepulveda, Rosalind Smyth, Fiona Stanley, Paul Stewart, Tessa Torres-Edejer, Hugh Watkins
Journal: BMJ (2000)
Differentiation of Cultured Epithelial Cells: Response to Toxic Agents
Authors: Robert H. Rice, Anthony D. LaMontagne, Catherine T. Petito, Xianhui Rong
Journal: Environmental Health Perspectives (1989)

Cell culture systems are instrumental in elucidating regulation of normal function and mechanisms of its perturbation by toxic substances. To this end, three applications of epithelial cells cultured with 3T3 feeder layer support are described. First, treatment of the premalignant human epidermal keratinocyte line SCC-12F2 with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate suppressed cell growth and differentiation. This agent produced a biphasic growth response greatly inhibiting cell growth at 1 to 10 nM, but much less above 100 nM. Expression of the differentiated functions involucrin and transglutaminase was found to be inhibited markedly at concentrations above 10 nM. Second, 3-methylcholanthrene toxicity was surveyed in a variety of rat epithelial cell types. The two most sensitive to growth inhibition were epidermal and mammary epithelial cells, while those from bladder, prostate, thyroid, and endometrium were insensitive to growth inhibition. Great differences were evident even among those cells derived from stratified squamous epithelia (epidermal, esophageal, vaginal, forestomach) despite their expression of aryl hydrocarbon hydroxylase activities to similar degrees. Finally, expression of estrogen receptors in rat endometrial cells was shown to be stimulated by the cAMP-elevating agent forskolin. Maximal stimulation of 3- to 6-fold occurred in 6 hr, compatible with a requirement for protein synthesis. Although expressing keratinocyte character (transglutaminase activity and envelope forming ability), the cells thus retain some hormonal character that may be modulated by cAMP-dependent kinase activity. Pursuit of such results will aid in understanding differences in response among cell types and species, in elucidating mechanisms of action of known toxic substances and, ultimately, in predicting toxicity of less well understood agents.
Abstract 12905: Gene Expression and Expression Quantifying Trait Loci Analysis of Left Atrium of Patients With Post-operative Atrial Fibrillation
Authors: Martin I Sigurdsson, Mahyar Heydarpour, Louis Saddic, Tzuu-Wang Chang, Stanton K Shernan, Prem Shekar, Sary Aranki, Gregory Couper, Jochen D Muehlschlegel, Simon C Body
Journal: Circulation (2015)

Introduction: The majority of information on the genetic background of atrial fibrillation (AF) results from genomic DNA variant analysis without consideration of tissue expression. Hypothesis: Analysis of tissue-specific gene expression in left atrium (LA) can further understanding of the molecular mechanism of identified AF risk variants, and identify novel genes and gene variants associated with AF. Methods: We isolated mRNA from samples of the LA free wall taken during mitral valve surgery in 62 Caucasian individuals. Gene expression in the LA was compared between patients who did and did not have post-operative AF (poAF) using high-throughput RNA expression. Using genotypes of 1.4 million single nucleotide polymorphisms (SNP) we performed cis expression quantifying trait loci (eQTL) analysis, correlating gene expression of each gene with the genotypes of adjacent (&lt;1Mbp) SNPs. Results: We identified 23 differentially expressed genes in the LA of patients with poAF, including three potassium channel genes (KCNA7, KCNH8 and KCNK17). The largest expression difference was in LOC645323, a long non-coding RNA. The expression of PITX2, ZFHX3 and KCNN3, previously shown to be associated with AF, did not differ between patients with and without poAF. We identified 12,476 cis eQTL relationships in the LA, several of those included genetic regions and genes previously associated with AF. We confirmed an eQTL relationship between rs3744029 genotype and the expression of MYOZ1. Furthermore we describe a novel eQTL relationship between rs6795970 genotype and the expression of the SCN10A gene. Conclusions: We have analysed the human LA expression via high-throughput RNA sequencing, and identified novel genes and gene variants likely involved in the molecular pathophysiology of AF.
Larval papule as a sign of scabies
Authors: W. B. Shelley
Journal: JAMA (1976)

NO CLINICAL sign in the skin is better known than the thread-like burrow hollowed out by the female itch mite. Truly a tunnel of love, it is in this burrow that copulation, ovulation, and birth of the larvae occur.<sup>1</sup>Pathognomonic as it is for scabies, the burrow has somewhat blunted our appreciation of the lesion produced by the developmental or junior forms of<i>Sarcoptes scabiei</i>, viz, the papule. It is exquisitely pruritic and arises quickly in response to a larval or nymphal mite boring into the outermost epidermis. Thus, the papule is surmounted by a virtually invisible chamber for the critical moulting phase. In the absence of burrows, it is these papules that must receive our closest attention in the search for the agent causing scabies. This communication outlines the prolonged complex diagnostic struggle that was eventually won only by finding the larval itch mite within its moulting chamber
State Boards of Registration.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal