tbuckley/cabot-search huggingface dataset:
Medicolegal Rounds
Journal: JAMA (1974)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Minnesota Rural Physician Redistribution Plan, 1971 to 1976
Authors: J. E. Verby
Journal: JAMA (1977)

The Rural Physician Associate Program was developed by the University of Minnesota Medical School faculty in an attempt to meet the demands of the citizens of Minnesota to improve the distribution of primary physicians to rural areas. The program is offered to students who have completed 2 2/3 academic years of medical school. There were no regulations requiring the students' return to rural areas after completion of training. Thus far, 163 students have completed the program. Forty-three have continued in medical school and another 27 are in residency-training programs. Primary care residencies have been chosen by 68; another 31 have completed their medical education and are in rural practice. Of the 22 practicing in Minnesota, 21 have returned to rural communities. (<i>JAMA</i>238:960-964, 1977)
Double Trouble
Authors: Christopher Smith, Gurpreet Dhaliwal, Sanjay Saint, Evan A. Farkash, Puneet Garg
Journal: New England Journal of Medicine (2019)

A 51-year-old man presented with a 4-week history of cough associated with fever, chills, fatigue, and aching in the joints. The cough was initially productive of blood-tinged phlegm but later became dry. His condition had not improved after two courses of macrolide antibiotic therapy.
The Toxicologic Effects of the Carbamate Insecticide Aldicarb in Mammals: A Review
Authors: John F. Risher, Franklin L. Mink, Jerry F. Stara
Journal: Environmental Health Perspectives (1987)

Aldicarb, 2-methyl-2-(methylthio)propionaldehyde-O-methylcarbamoyloxime, is an oxime carbamate insecticide manufactured by the Union Carbide Corporation and sold under the trade name Temik. It is a soil-applied systemic pesticide used against certain insects, mites, and nematodes, and is applied below the soil surface for absorption by plant roots. It is generally applied to the soil in the form of 5, 10, or 15% granules, and soil moisture is essential for the release of the toxicant. Uptake by plants is rapid. Aldicarb is currently registered for use on cotton, sugar beets, sugar cane (Louisiana only), potatoes, sweet potatoes, peanuts, oranges, pecans (Southeast only), dry beans, soybeans, and ornamental plants. Home and garden use is not permitted. Discovery of aldicarb and its oxidative sulfoxide and sulfone metabolites in well or ground water in Florida, Wisconsin, and New York, and accidental poisonings from ingesting contaminated watermelons and cucumbers in the South and West have spurred interest and concern about this pesticide. The primary mechanism of toxic action of aldicarb is cholinesterase inhibition. However, unlike the relatively irreversible anticholinesterase activity of the organophosphate pesticides, the carbamylation process which produces the anti-AChE action is quickly reversible. Aldicarb is readily absorbed through both the gut and the skin, but is rapidly metabolized and excreted in the urine almost completely within 24 hr. Although it is acutely toxic to humans and laboratory animals, aldicarb is not known to be carcinogenic, teratogenic, conclusively mutagenic, or to produce other long-term adverse health effects. In cases of accidental poisoning, the cholinergic symptoms have generally subsided within 6 hr, with no side effects or complications.
The Lumleian Lectures on the Pathological Relations of the Voice and Speech
Authors: J. S. Bristowe
Journal: BMJ (1879)

CONSONANTS differfrom vowels in being unmusical sounds or noises formed by the interposition of checks or barriers to the free passage of air through the oral cavity, or at any rate by the interposition of more complete barriers than those which are formed during the evolution of the vowel-sounds; at which barriers, instead of in the larynx, the funda- mental sounds of the consonants are produced.This fundamental
Correlation of Australia antigen with posttransfusion hepatitis
Authors: D. J. Gocke
Journal: JAMA (1970)

Transfusion of blood containing Australia antigen was associated with development of hepatitis or an antibody response in 74% (31 of 42) recipients. However, hepatitis also occurs in recipients of antigen-negative donor blood. Further study is required to determine precisely how much hepatitis could be prevented by screening donor blood for Australia antigen. At present, it appears that about 25% of transfusion hepatitis could be prevented in this way, and we are optimistic that this figure can be revised upward.
Candida parapsilosis endocarditis. Recovery of the causative organism from an addict's own syringes
Authors: R. D. Brandstetter
Journal: JAMA (1980)

ENDOCARDITIS due to bacterial and fungal pathogens is a special problem in the addict population, with more than 20% of fungal endocarditis being associated with drug addiction.<sup>1</sup>It has been postulated that intravenous (IV) injections of adulterated substances, such as illicit heroin, can cause fibrotic changes in cardiac valves predisposing to subsequent microbial endocarditis; however, the source of the pathogen has not been elucidated in these infections.<sup>2</sup>We report here a case of<i>Candida parapsilosis</i>endocarditis in which the infecting organism was cultured from the patient's injection paraphernalia. <h3>Report of a Case</h3> A 24-year-old male drug addict was admitted with a one-week history of fever, weakness, fatigue, and arthralgias. He gave a history of heroin addiction for eight years, and he had had<i>Staphylococcus aureus</i>endocarditis requiring aortic valve replacement five years before this admission. On five occasions during the preceding three months, and most recently two weeks
Clinical Neurosurgery
Authors: Arnold B. Calica
Journal: JAMA (1978)

This volume, the 24th in its series, honors Dr Lyle French; six chapters are devoted to material by or about him. The remaining 42 chapters can be divided into the following topics: parasellar lesions, occult hydrocephalus, peripheral nerve injury, cervical spondylosis, trigeminal neuralgia, and miscellany. For most of these, the coverage includes a chapter on pathophysiology, several chapters on treatment, and a panel discussion. Some chapters of particular interest are those dealing with cerebral arteriovenous malformations, the microsurgical anatomy of the parasellar region, the role of vascular compression in the etiology of trigeminal neuralgia, and the treatment of epilepsy. Although the material included in this volume is almost bewildering in its diversity, congratulations are due for the generally high quality of the articles provided. The inclusion of material on pathophysiology will make this book appeal to a somewhat larger group of readers than the neurosurgical specialists for whom it is
Council on Pharmacy and Chemistry and Council on Foods and Nutrition
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hepatology highlights
Authors: Neil Kaplowitz
Journal: Hepatology (2002)

Being Naked Attracts BystandersManagement of unresectable colon cancer in the liver is a common dilemma.Baque et al. have developed an exciting approach, namely direct injection of naked DNA plasmid containing the suicide gene, cytosine deaminase, followed by treatment with 5-fluorocytosine, which is converted to 5-FU by the expressed suicide gene.These experiments were conducted in rats with established liver tumors after receiving cancer cells into the right and left lobes.Naked DNA was injected only in the left lobe tumors.Despite limited suicide gene expression, both left and right lobe tumors regressed with treatment indicating a local and distant bystander effect, which was associated with NK cell infiltration of tumors.Thus, the local killing of cancer cells seems to trigger a systemic immune response.Although more work is needed to address how the plasmid is taken up by cancer cells, to define the specific target of the immune response, and to optimize the treatment, this appears to be a promising approach for treatment of unresectable liver tumors.(See
GUAYAQUIL
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Metabolic Contrasts Between Youth and Adults With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes: II. Observations Using the Oral Glucose Tolerance Test
Authors: David A. Ehrmann, Karla A. Temple, Abby Rue, Elena Barengolts, Babak Mokhlesi, Eve Van Cauter, Susan Sam, M. Annette Miller, Steven E. Kahn, Karen M. Atkinson, Jerry P. Palmer, Kristina M. Utzschneider, Tsige Gebremedhin, Abigail Kernan-Schloss, Alexandra Kozedub, Brenda K. Montgomery, Emily J. Morse, Kieren J. Mather, Tammy Garrett, Tamara S. Hannon, Amale Lteif, Aniket Patel, Robin Chisholm, Karen Moore, Vivian Pirics, Linda Pratt, Kristen J. Nadeau, Susan Gross, Philip S. Zeitler, Jayne Williams, Melanie-Cree Green, Yesenia Garcia Reyes, Krista Vissat, Silva A. Arslanian, Kathleen Brown, Nancy Guerra, Kristin Porter, Sonia Caprio, Mary Savoye, Bridget Pierpont, Thomas A. Buchanan, Anny H. Xiang, Enrique Trigo, Elizabeth Beale, Fadi N. Hendee, Namir Katkhouda, Krishan Nayak, Mayra Martinez, Cortney Montgomery, Xinhui Wang, Sharon L. Edelstein, John M. Lachin, Ashley N. Hogan, Santica Marcovina, Jessica Harting, John Albers, Dave Hill, Peter J. Savage, Ellen W. Leschek
Journal: Diabetes Care (2018)

To compare oral glucose tolerance test (OGTT) glucose, C-peptide, and insulin responses and insulin sensitivity in youth and adults with impaired glucose tolerance (IGT) or recently diagnosed type 2 diabetes.A total of 66 youth (80.3% with IGT) and 355 adults (70.7% with IGT) underwent a 3-h OGTT to assess 1) insulin sensitivity (1/fasting insulin), 2) C-peptide index (CPI) and insulinogenic index (IGI) over the first 30 min, and 3) glucose, C-peptide, and insulin incremental areas above fasting over the 3-h post-ingestion (incremental glucose [G-iAUC], incremental C-peptide [CP-iAUC], and incremental insulin area under the curve [I-iAUC] responses, respectively).Fasting, 2-h glucose, and G-iAUC were similar in both age-groups, but youth had ∼50% lower 1/fasting insulin (P < 0.001), 75% higher CPI (mean [95% CI] 0.703 [0.226, 2.183] vs. 0.401 [0.136, 1.183] nmol/mmol; P < 0.001), and more than twofold higher IGI (257.3 [54.5, 1,215.8] vs. 114.8 [28.0, 470.8] pmol/mmol; P < 0.001). Two-hour C-peptide and insulin concentrations, CP-iAUC, and I-iAUC were all higher in youth (all P < 0.001). C-peptide and insulin responses remained significantly greater in youth after adjustment for insulin sensitivity. Within each age-group, individuals with type 2 diabetes versus IGT had significantly lower CPI and IGI with no difference in insulin sensitivity.The balance between insulin sensitivity and β-cell responses differs between youth and adults with IGT or recently diagnosed type 2 diabetes. Despite similar postload glucose levels, youth demonstrate greater C-peptide and insulin responses that exceed what is needed to compensate for their lower insulin sensitivity. Longitudinal studies are required to determine whether this feature contributes to a more rapid decline in β-cell function in youth with dysglycemia.
PROFESSIONAL APATHY.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Quantitative Assessment of Lives Lost Due to Delay in the Regulation of Occupational Exposure to Benzene
Authors: William J. Nicholson, Philip J. Landrigan
Journal: Environmental Health Perspectives (1989)

Benzene exposure can cause leukemia, aplastic anemia, and possibly lymphoma. In 1978, on the basis of strong but incomplete data then available on the risk of benzene-induced leukemia, the U.S. Occupational Safety and Health Administration (OSHA) reduced the permissible occupational exposure standard for benzene from 10 ppm to 1 ppm. Shortly thereafter, the Fifth Circuit Court of Appeals stayed this ruling, and in 1980, the Supreme Court overturned the regulation, citing insufficient evidence of benefit. Thus, from 1978 until the standard was again lowered to 1 ppm in 1987, American workers were exposed to benzene at levels in excess of 1 ppm. An estimated 9600 were exposed to levels between 1 and 10 ppm, and an additional 370 were exposed at levels above 10 ppm. To assess the risk resulting from this delay in regulation, we have conducted an epidemiologic risk analysis. We merged data on numbers of persons (238,000) exposed to benzene in seven occupational categories with dose-response data from three epidemiologic studies. The range of risk in these studies indicates that 44 to 152 excess leukemia deaths will ultimately result from exposure to benzene at 10 ppm over a working lifetime (45 years) and that lower or briefer exposures will result in proportionately fewer deaths. On this basis, we calculated that between 30 and 490 excess leukemia deaths will ultimately result from occupational exposures to benzene greater than 1 ppm that occurred between 1978 and 1987. Deaths from aplastic anemia and lymphoma will likely add to this toll. These data confirm the risk of regulatory delay. They suggest that the courts, in reviewing public health regulations, must beware of facile cost-benefit arguments and be willing to accept strong evidence of health risk even when such evidence is incomplete.
ASSOCIATION NEWS.
Authors: J. W. Graham, W. A. Jayne
Journal: JAMA (1898)

<h3>Rates for the Denver Meeting.</h3> —The Committee on Transportation announce that the final decision of the New England roads and those of the Trunk Lines territory in the matter of rates for the Denver meeting, is for one full fare plus one-third full fare returning on the certificate plan. Tickets will be sold three days before the meeting, Sunday excepted, and the certificates must be presented at Denver properly filled out, not later than three days after the close of the meeting, when the return ticket will be sold for one-third the cost of the regular fare. Tickets sold in the New England and Trunk Lines territory must be used for continuous passage, both going and returning over the same lines, no diverse route returning having been granted. The Central Traffic has granted one fare for the round trip plus $4 for diverse route privilege. The Western Association has granted
Unproven Methods of Cancer Treatment: Livingston Vaccine
Journal: CA A Cancer Journal for Clinicians (1968)

After careful study of the literature and other information available to it, the Ameri can Cancer Society has not found evidence that treatment with the Livingston Vaccine results in objective benefit in the treatment of cancer, or that diagnosis by means of the presence of PPLO in the urine or blood is a reliable method of detecting cancer in human beings.The following is a summary of information on the Livingston methods in the American Cancer Society files: TherapyIn 1953, at the 6th International Congress of Microbiology in Rome, Italy, a team of re searchers from the Presbyterian Hospital, Newark, New Jersey, headed by Virginia Wuerthele-Caspe, M.D. reported that they had developed a vaccine and antisera, which gave â€oe¿ encouraging resultsâ€• in preliminary studies.This was based on their belief that cancer is a generalized disease caused by a pleomorphic microorganism in the human blood stream.They claimed to have recovered this organism from the blood and tissues of hundreds of cancer patients.They also stated that while normal carriers of this organism were found, 100% of the blood of cancer pa tients had given a positive culture in a spe cial broth.
Experimental Induction of Ovarian Sertoli Cell Tumors in Rats by N-Nitrosoureas
Authors: Akihiko Maekawa, H. Onodera, H. Tanigawa, K. Furuta, J. Kanno, T. Ogiu, Y. Hayashi
Journal: Environmental Health Perspectives (1987)

Spontaneous ovarian tumors are very rare in ACI, Wistar, F344 and Donryu rats; the few neoplasms found are of the granulosa/theca cell type. Ovarian tumors were also rare in these strains of rats when given high doses of N-alkyl-N-nitrosoureas continuously in the drinking water for their life-span; however, relatively high incidences of Sertoli cell tumors or Sertoli cell tumors mixed with granulosa cell tumors were induced in Donryu rats after administration of either a 400 ppm N-ethyl-N-nitrosourea solution in the drinking water for 4 weeks or as a single dose of 200 mg N-propyl-N-nitrosourea per kg body weight by stomach tube. Typical Sertoli cell tumors consisted of solid areas showing tubular formation. The tubules were lined by tall, columnar cells, with abundant, faintly eosinophilic, often vacuolated cytoplasm, and basally oriented, round nuclei, resembling seminiferous tubules in the testes. In some cases, Sertoli cell tumor elements were found mixed with areas of granulosa cells. The induction of ovarian Sertoli cell tumors in Donryu rats by low doses of nitrosoureas may provide a useful model for these tumors in man.
Pathological Contributions to Medical Jurisprudence
Authors: W. B. Mushet
Journal: BMJ (1859)

for the moment, was embalrassing-in doubt how to proceed- whether to divide the mass or remove it; being, firmly per- suaded that an hernial protruision must be found in close con- tingency, I dissected on the inner side of this mass, and on pushing it on one side, I saw deeply imbedded the object of ouLr search-a knuckle of strangulated intestine, and its sac quite detached from the overlying mass of gland.We judged
Reframing Gun Violence
Authors: Frank Davidoff
Journal: Annals of Internal Medicine (1998)

Letters15 August 1998Reframing Gun ViolenceFrank Davidoff, MD, EditorFrank Davidoff, MD, EditorEditorSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-129-4-199808150-00027 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:I agree with Dr. Keen on the importance of defending the Constitution, but he seems to have confused the issues raised by my editorial with some others included in the ACP position paper [1]. My editorial had little to do with Constitutional issues, unless it be the First Amendment right of physicians to counsel their patients about safe gun use. Besides, a major reason Big Brother is legislating gun use is that so many people are now being killed and disabled with guns, all the more reason we need better nongovernmental ways to control gun-related damage.Living in ...References1. Firearm injury prevention. American College of Physicians. Ann Intern Med. 1998; 128:236-41. Google Scholar Author, Article, and Disclosure InformationAffiliations: Editor PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 August 1998Volume 129, Issue 4Page: 338KeywordsChildrenDisabilitiesDrugsHomicideSmoking cessationStable coronary artery diseaseSuicideThrombosisTyphoidViolent crime Issue Published: 15 August 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...