tbuckley/cabot-search huggingface dataset:
Handbuch der Erbkrankheiten
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SPIROCHETAL PULMONARY GANGRENE TREATED WITH ARSPHENAMINS
Authors: B. S. KLINE
Journal: JAMA (1925)

In a previous article,<sup>1</sup>it was stated that "evidence is accumulating that pulmonary gangrene may be caused by spirochetes and fusiform bacilli aspirated from an unclean mouth, and that it may be prevented by proper oral hygienic measures. Furthermore, when the condition is once established a diagnosis can be made early by finding the organisms in the washed sputum, thus offering an opportunity for successful specific treatment with the arsphenamins." The etiologic relationship of spirochetes and fusiform bacilli to pulmonary gangrene is evidenced not only by the predominance of these organisms in early gangrenous areas but also by the fact that gangrene with death in a few days was produced in guinea-pigs<sup>2</sup>by the injection into traumatized tissues of material from pyorrhea alveolaris, dental caries, pulmonary gangrene and Vincent's angina containing innumerable Vincent spirochetes and fusiform bacilli. The organisms in the material from four cases of Vincent's angina
Evaluation of percentage of free serum prostate-specific antigen to improve specificity of prostate cancer screening
Authors: W. J. Catalona
Journal: JAMA (1995)

<h3>Objective.</h3> —To evaluate measurement of percentage of free prostate-specific antigen (PSA) in serum to improve the specificity of prostate cancer screening in men with serum PSA levels between 4.1 and 10.0 ng/mL. <h3>Design.</h3> —Retrospective, nonrandomized analysis using a research assay for measuring free PSA in frozen serum from men with a spectrum of prostate sizes and digital rectal examination results. <h3>Setting.</h3> —General community outpatient prostate cancer screening program at a university center. <h3>Patients.</h3> —One hundred thirteen men aged 50 years or older, 99% of whom were white, with serum PSA concentrations of 4.1 to 10.0 ng/mL, including 63 men with histologically confirmed benign prostatic hyperplasia, 30 with prostate cancer with an enlarged gland, and 20 with cancer with a normal-sized gland. All study volunteers had undergone prostatic ultrasonography and biopsy. <h3>Main Outcome Measures.</h3> —Percentage of free PSA in serum and percentage of free PSA cutoff that maintained at least 90% sensitivity for prostate cancer detection. <h3>Results.</h3> —Median percentage of free PSA was 9.2% in men with cancer and a normal-sized gland, 15.9% in men with cancer and an enlarged gland, and 18.8% in men with benign prostatic hyperplasia (<i>P</i>&lt;.001). The percentage of free PSA cutoff was higher in men with an enlarged gland and in those with a palpably benign gland. In men with an enlarged, palpably benign gland, a free PSA cutoff of 23.4% or lower detected at least 90% of cancers and would have eliminated 31.3% of negative biopsies. <h3>Conclusions.</h3> —Measurement of percentage of free serum PSA improves specificity of prostate cancer screening in selected men with elevated total serum PSA levels and can reduce unnecessary prostate biopsies with minimal effects on the cancer detection rate; however, further studies are needed to define optimal cutoffs. Final evaluation of PSA screening also must consider the ability of current treatments to improve the prognosis of screen-detected prostate cancer. (<i>JAMA</i>. 1995;274:1214-1220)
Obstetrics and Gynecology
Authors: Anne Colston Wentz
Journal: JAMA (1994)

Contraceptive development has taken a new direction in the face of the acquired immunodeficiency syndrome epidemic, the high incidence of teenage pregnancy, and the need for acceptable, female-controlled family planning methods. Sexually transmitted diseases (STDs) are a particular problem, as women suffer most of their consequences, including pelvic inflammatory disease, infertility, and tubal pregnancy. Heterosexual transmission of human immunodeficiency virus (HIV) accounts for the alarming increase in its incidence in reproductive-age women. Thus, new contraceptive strategies must be sought. Needed is a safe, female-controlled method that would be effective in preventing both pregnancy and the transmission of STDs, including HIV. The female condom is a welcome addition, but its contraceptive and STD prevention efficacy need further study. There is an 11% to 15% rate of accidental pregnancy at 6 months for women who use the the female condom (similar to rates for other barrier contraceptive methods for women); however, rates
Fetal, Infant, and Childhood Growth Are Predictors of Coronary Heart Disease, Diabetes, and Hypertension in Adult Men and Women
Authors: Clive Osmond, David J. P. Barker
Journal: Environmental Health Perspectives (2000)

Many human fetuses have to adapt to a limited supply of nutrients.In doing so they permanently change their structure and metabolism.These programmed changes may be the origins of a number of diseases in later life, including coronary heart disease, hypertension and noninsulin- dependent diabetes.We review epidemiologic studies in which the incidence of these diseases has been related to the recorded, early growth of individuals, while considering factors in the adult lifestyle, such as obesity and socioeconomic status.We discuss possible mechanisms.For hypertension these mechanisms include placentation, maternal blood pressure, fetal undernutrition; childhood growth, activation of the renin-angiotensin system, renal structure, programming of the hypothalamic-pituitary-adrenal axis, vascular structure, and sympathetic nervous activity.For noninsulin-dependent diabetes we discuss mechanisms concerning both insulin resistance and insulin deficiency.We include a review of evidence for the programming of serum cholesterol and clotting factor concentrations.We address the timing of critical windows for coronary heart disease, reviewing studies that allow assessment of the relative importance of fetal, infant, and childhood growth.We argue for a research strategy that combines clinical, animal, and epidemiological studies.
A SECRETARY OF PUBLIC HEALTH.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
UNIQUE CASE OF FOREIGN BODY IN THE RECTUM
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
"Prolonged shedding of rhinovirus and re-infection in adults with respiratory tract illness." Kalina T. Zlateva, Jutte J.C. de Vries, Frank E.J. Coenjaerts, Anton M. van Loon, Theo Verheij, Paul Little, Christopher C. Butler, Herman Goossens, Margareta Ieven and Eric C.J. Claas on behalf of the GRACE Study Group. Eur Respir J 2014; 44: 169-177.
Journal: European Respiratory Journal (2014)
An Intensive Treatment Program of Interpersonal Psychotherapy Plus Pharmacotherapy for Depressed Inpatients: Acute and Long-Term Results
Authors: Elisabeth Schramm
Journal: American Journal of Psychiatry (2007)

Objective: The purpose of this article was to determine the relative efficacy of a psychotherapy program when combined with pharmacotherapy versus medication and clinical management in more severely depressed patients. Method: A randomized controlled trial was conducted in 124 hospitalized patients with DSM-IV major depressive disorder that compared 5 weeks of interpersonal psychotherapy modified for depressed inpatients (15 individual and eight group sessions) plus pharmacotherapy with a regimen that involved medication plus intensive clinical management. The study included a prospective, naturalistic follow-up 3 and 12 months after acute treatment in 97 of 105 treatment completers. The 17-item version of the Hamilton Depression Rating Scale (HAM-D) was the primary outcome measure. Results: For the intent-to-treat cohort (N=124), analysis of covariance (ANCOVA) showed that patients treated with interpersonal psychotherapy had a significantly greater reduction of depressive symptoms at week 5. Response rates differed significantly between the two treatment conditions, favoring the group that received adjuvant interpersonal psychotherapy (70%) versus clinical management (51%). Remission rates also tended to be higher for patients in the interpersonal psychotherapy group (49% versus 34%). Patients who initially responded to interpersonal psychotherapy exhibited greater treatment gains at the 3-month follow-up evaluation, since only 3% of these subjects relapsed, compared with 25% of the clinical management subjects. Nine months later, this difference lost statistical significance. Conclusions: An inpatient treatment program with both brief and intensive psychotherapy plus pharmacotherapy is superior to standard treatment. The results, which add to a growing body of evidence, suggest that this combination treatment may offer an advantage over treatment with medication and clinical management for more severely depressed patients.
Safety and Side Effects of Sustained-Release Niacin
Authors: Joseph M. Keenan
Journal: JAMA (1994)

<h3>To the Editor.</h3> —The study by Dr McKenney and colleagues<sup>1</sup>is described by the authors as a "well-designed clinical trial." We would concur with that description if the authors would make more explicit the intention of the study, namely, that it was clearly designed to maximize the potential for niacin intolerance and toxicity. Despite their obvious familiarity with the clinical literature, they chose a peculiarly unphysiologic twice-daily dosing schedule. Similarly, they intentionally escalated both the immediate-release (IR) nicotinic acid and sustained-release (SR) nicotinic acid to a total dose of 3000 mg (1500 mg twice daily), whether or not the patient had demonstrated an adequate lipid response at a lower dose.
PARIS
Journal: JAMA (1929)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Crystalline Lens System. Its Embryology, Anatomy, Physiologic Chemistry, Physiology, Pathology, Diseases, Treatment, Operations and After-changes, with a consideration of Aphakia.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Opinions of the Medical Conference
Journal: BMJ (1841)

That the Council do not consider that the Provincial Medical and Surgical Association is pledged to su1pport the bill which may have been adopted by the con- ference of the medical associations in London, since some of the delegates appointed by their Council have not at- tended,* and others have resigned,t and the Council are ignoratt of the nature of the clauses of the proposed bill.Resolved,-That this CoseIl thipk it desirable that the reform proposed by the nmedical coiporations in London should be
Hypothalamic hypothyroidism
Authors: L. Shenkman
Journal: JAMA (1972)

Hypothalamic hypothyroidism was identified in a 53-year-old man. Two years before developing hypothyroidism, he manifested somnolence, transient diabetes insipidus, and altered thirst perception. Pneumoencephalograms revealed absence of the corpus callosum. Thyroid function tests disclosed decreased serum thyroxine and triiodothyronine (T<sub>3</sub>), low basal metabolic rate, and diminished thyroidal uptake of radioactive iodine (RAI). Basal thyrotropin levels were normal and rose promptly after the intravenous administration of thyrotropin releasing hormone (TRH). Basal T<sub>3</sub>levels were low and did not rise in response to TRH although T<sub>3</sub>level and RAI uptake rose after the intramuscular administration of thyrotropin.
Alan S. Rabson (1926-2018)
Authors: Alan Rabson, Jos E Costa, Elaine Jaffe, Peter Howley, Lance Liotta
Journal: JNCI Journal of the National Cancer Institute (2018)

the biomedical research community has lost an important beacon, one that guided and inspired generations of young physician-scientists and counseled many a senior administrator and policy-maker in the arena of cancer research.Born and raised in New York City (Brooklyn),
MISQUOTATIONS AND MISUNDERSTANDINGS.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Experimental pinta in the chimpanzee
Authors: U. S. Kuhn
Journal: JAMA (1968)

Pinta is a dermatrophic treponemal disease with immunologic similarities to syphilis but without its generalized and serious consequences. Workers in treponemal immunology have long been intrigued with the possible use of<i>Treponema carateum</i>, the causative agent of pinta, to confer immunity to syphilis.<sup>1</sup>Failure in attempts to establish the disease in experimental animals has impeded the laboratory study of the organism. However, chimpanzees have not heretofore been studied under controlled conditions for their susceptibility to inoculation with<i>T carateum</i>from humans with pinta. The susceptibility of chimpanzees to human syphilis, as reflected in current studies at the Venereal Disease Research Laboratory, and the close immunologic relationship of chimpanzees to man, prompted exploration of the premise that<i>T carateum</i>might also be transferable to these animals. Because pinta does not occur in the United States but can be found to occur to a limited extent in Mexico, a collaborative effort
Physicians called upon to help chart future space effort
Authors: C. Marwick
Journal: JAMA (1986)

CONGRESS, THE PRESIDENT, and a task force of NASA's Advisory Council are studying a report that looks beyond the present gloom and offers a glowing forecast—with implications for medicine—for the next 50 years of space exploration. The nation's space program has received more scrutiny in a shorter time this year than perhaps any federal activity in history. This latest report was prepared by members of the National Commission on Space. In effect, their report (the commission itself ceased to exist this summer, 60 days after the report was transmitted to the President and Congress) supports NASA's humans-in-space policy, including what medicine can learn about prolonged exposure to that environment. And, in turn, NASA officials support the commission's report, saying they intend to carry out its recommendations. Although humans have been taking journeys into space for a quartercentury with the declared goal of eventually living and working there for protracted periods
Retroperitoneal fibrosis and avascular necorsis of the femoral head
Authors: R. A. Appell
Journal: JAMA (1976)

A REPORT of avascular necrosis of the head of the femur in a patient that ten years previously had had confirmed retroperitoneal fibrosis<sup>1</sup>provoked interest in the possible association between the two entities when a patient with retroperitoneal fibrosis who had previously undergone surgery for avascular necrosis of the femoral head was encountered. <h3>Report of a Case</h3> A 44-year-old woman was admitted to Yale-New Haven Hospital with left costovertebral angle pain radiating to the lower abdomen, dysuria, intermittent hematuria and a history of previous pyelonephritis. She had the left femoral head replaced by an Austin-Moore prosthesis 18 months previously for confirmed avascular necrosis of the femoral head. The patient denied corticosteroid or methysergide maleate use, but admitted to heavy use of "over-the-counter" analgesics, alcohol, and cigarettes. The patient appeared cachectic and lethargic. Her temperature was 37 C, and she had moderate left costovertebral angle tenderness. A chest x-ray film
Postemetic rupture of herniated cardia of the stomach
Authors: E. C. James
Journal: JAMA (1984)

<h3>To the Editor.—</h3> I refer to the Letter to the Editor by Gallivan<sup>1</sup>commenting on our article entitled "Postemetic Rupture of Herniated Cardia of the Stomach."<sup>2</sup>Although this is a somewhat delayed response to that letter, I believe that there still may be something new above the diaphragm after all. Our case represents a classic postemetic or spontaneous rupture similar to that reported by Boerhaave<sup>3</sup>in 1724 with the exception that the anatomic site of rupture occurred in a herniated cardia of the stomach rather than in the lower esophagus. In postemetic rupture, the cause remains unclear, but it is postulated that the extension of smooth-muscle fibers from the esophagus onto the stomach wall results in a defective or weakened muscular zone. As we mentioned in our article, the perforation is almost always in the lower third of the esophagus, and about 90% occur on the left