tbuckley/cabot-search huggingface dataset:
Portal vein embolization with steel coils and absolute ethanol: A comparative experimental study with canine liver
Authors: K YAMAKADO
Journal: Hepatology (1995)

Portal vein embolization (PVE) is expected to have an adjuvant effect on the treatment of human liver tumors with transcatheter hepatic arterial embolization (TAE). In this experimental study, PVE was tried using two kinds of embolic materials, steel coils (coils) and absolute ethanol (ethanol). The aim of this article is to compare the effectiveness between the two methods. Five dogs and 12 dogs were treated with coils and ethanol, respectively. The second order portal branches were embolized. Embolization effects of each embolic material on the hepatic vessels and the liver parenchyma were studied angiographically and histologically. PVE with coils achieved immediate occlusion of the embolized vessels in all dogs. Unexpectedly, unembolized vessels were also constricted and/or obstructed in 4 of 5 dogs during a 4-week follow-up period. Histological examination showed no hepatic necrosis in all dogs. By contrast, in the dogs treated with ethanol, venous occlusion was achieved immediately after embolization with ethanol of 0.4 mL/kg or more. The embolized vessels remained occluded and no obstruction of unembolized vessels was observed until 4 weeks after embolization. Hepatic necrosis was observed in the segments where portal veins were occluded. The degree of parenchymal damage was proportional to the injected ethanol dose. Judging from these results, ethanol is likely to be more suitable than coils as an embolic material for PVE. PVE with coils is often dangerous because unembolized vessels might be occluded unexpectedly. For the clinical use of PVE with thanol, the appropriate dose of injection should be investigated. (Hepatology 1995; 22:1812-1818).
Ceftriaxone-Associated Biliary Complications of Treatment of Suspected Disseminated Lyme Disease—New Jersey, 1990-1992
Journal: JAMA (1993)

Lyme disease (LD) is endemic in Monmouth and Ocean counties, New Jersey (1). In June 1992, CDC and the New Jersey Department of Health (NJDOH) conducted a telephone survey in both counties of 65 schoolchildren who required home instruction because of suspected LD to determine the public health impact of the disease. Most children had received prolonged and repeated courses of oral antimicrobials and/or home intravenous infusion of antimicrobials; 79% had been hospitalized for treatment of suspected LD or management of treatment complications, most notably drug-induced symptoms of gallbladder disease occurring in patients receiving ceftriaxone (Rocephin), and bloodstream infections associated with intravenous catheters. To determine the characteristics of and treatment complications for patients hospitalized for treatment of LD, a computerized search of hospital discharge data in New Jersey was performed; nearly 30% of all hospitalizations for LD during 1990-1991 were at a regional hospital serving Monmouth and Ocean counties. This report presents findings of an analysis of patients admitted to that hospital for treatment of LD.
Survival Outcomes in Blastic Plasmacytoid Dendritic Cell Neoplasm By First-Line Treatment and Stem Cell Transplant
Authors: Seongseok Yun, Onyee Chan, Daniel Kerr, Nicole D. Vincelette, Afshan Idrees, Qianxing Mo, Kendra Sweet, Jeffrey E. Lancet, Mohamed A kharfan-Dabaja, Ling Zhang, Lubomir Sokol
Journal: Blood (2020)
Leads from the MMWR. Revision of the CDC surveillance case definition for acquired immunodeficiency syndrome
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MADRID
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Severe anaphylactoid reaction to radiographic contrast media. Recurrences despites premedication with diphenhydramine and prednisone
Authors: J. S. Madowitz
Journal: JAMA (1979)

Patients with a history of anaphylactoid reaction to radiographic contrast medium (RCM) are at increased risk for subsequent reaction. To date, 275 of these high-risk patients have been studied with use of prophylactic pretreatment with diphenhydramine hydrochloride or prednisone or both without a single severe anaphylactoid reaction on readministration of RCM. This report describes a patient who received pretreatment as described in the literature but suffered a life-threatening anaphylactoid reaction on readministration of RCM. Premedication does not eliminate the possibility of a fatal reaction on readministration of RCM. (<i>JAMA</i>241:2813-2815, 1979)
Longitudinal Assessment of Plasma ADAMTS13 Biomarkers Helps Predict Recurrence of Immune Thrombotic Thrombocytopenic Purpura
Authors: Jingrui (Jean) Sui, Wenjing Cao, Mohammad S. Abdelgawwad, Konstantine Halkidis, Nicole K. Kocher, Bryan K. Guillory, Lance A. Williams, Marisa B. Marques, Radhika Gangaraju, X. Long Zheng
Journal: Blood (2019)
Ready! Fire!... Aim!
Authors: Edward T. Wong
Journal: JAMA (1983)

Informal test-ordering protocols that do not follow a physiological rationale are common in teaching hospitals and represent part of the folklore of resident practice. Such faulty test-ordering routines increase the cost of care, waste resources, may fail to answer diagnostic questions, or may generate false leads. They prove to be part of a broader set of issues in information management not restricted to medicine. Clinically appropriate algorithms for diagnostic testing can be constructed to replace folkloric protocols. This should represent a major area of professional concern in clinical pathology. (<i>JAMA</i>1983;250:2510-2513)
A Variety of Environmentally Persistent Chemicals, Including Some Phthalate Plasticizers, Are Weakly Estrogenic
Authors: Susan Jobling, Tracey Reynolds, Roger White, Malcolm G. Parker, John P. Sumpter
Journal: Environmental Health Perspectives (1995)

Sewage, a complex mixture of organic and inorganic chemicals, is considered to be a major source of environmental pollution. A random screen of 20 organic man-made chemicals present in liquid effluents revealed that half appeared able to interact with the estradiol receptor. This was demonstrated by their ability to inhibit binding of 17 beta-estradiol to the fish estrogen receptor. Further studies, using mammalian estrogen screens in vitro, revealed that the two phthalate esters butylbenzyl phthalate (BBP) and di-n-butylphthalate (DBP) and a food antioxidant, butylated hydroxyanisole (BHA) were estrogenic; however, they were all less estrogenic than the environmental estrogen octylphenol. Phthalate esters, used in the production of various plastics (including PVC), are among the most common industrial chemicals. Their ubiquity in the environment and tendency to bioconcentrate in animal fat are well known. Neither BBP nor DBP were able to act as antagonists, indicating that, in the presence of endogenous estrogens, their overall effect would be cumulative. Recently, it has been suggested that environmental estrogens may be etiological agents in several human diseases, including disorders of the male reproductive tract and breast and testicular cancers. The current finding that some phthalate compounds and some food additives are weakly estrogenic in vitro, needs to be supported by further studies on their effects in vivo before any conclusions can be made regarding their possible role in the development of these conditions.
Unreviewed Reports
Authors: C Anastassiades, M Ioannides
Journal: BMJ (1984)

Unreviewed ReportsOrganophosphate poisoning and auricular fibrillation Two men aged 35 and 49 poisoned with parathion developed auricular fibrillation six and two hours after exposure.Their skin was washed, and atropine and pralidoxime were given.Heart rates reverted to sinus rhythm after six and eight hours.Both had no history of heart trouble, were normotensive, and did not smoke or drink.Electrolyte concentrations, subsequent electrocardiograms, two dimensional echocardiograms, and results of treadmill exercise and thyroid function tests were normal.They had not had any recurrence after 34 and 10 months respectively.We have not seen this complication in over 200 other patients.Thus organophosphate poisoning may be a rare cause of paroxysmal auricular fibrillation.
Staphylococcus aureus endocarditis. Combined therapy with vancomycin and rifampin
Authors: R. J. Faville
Journal: JAMA (1978)

Two children with persistent bacteremia and endocarditis due to<i>Staphylococcus aureus</i>failed to respond to vancomycin therapy, even though serum levels greatly exceeded the inhibitory concentrations. The<i>Staphylococcus</i>from one patient was resistant to methicillin; the other patient had a penicillin hypersensitivity. There was a wide disparity between the minimum inhibitory and the minimum bactericidal concentrations of vancomycin. Striking clinical and laboratory evidence of improvement was demonstrated with the addition of rifampin therapy. (<i>JAMA</i>240:1963-1965, 1978)
Vinyl and Related Polymers: Their Preparations, Properties, and Applications in Rubbers, Plastics, Fibers, and in Medical and Industrial Arts.
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Geriatric medicine
Authors: T. M. Gill
Journal: JAMA (1995)

This year geriatric medicine was characterized not by any watershed discoveries but rather by important efforts aimed at providing scientific evidence to support or refute many common treatment practices. Notably, investigators focused increasing attention on pertinent functional outcomes, usually to augment but occasionally to replace traditional measures of mortality and disease-specific events. A series of reports provided preliminary data on promising new strategies to diagnose and treat Alzheimer's disease. Coronary heart disease (CHD) and stroke are among the leading causes of disability and death in older adults. Strategies to prevent, forestall, and treat these common disorders, although effective in younger adults, often have unproved benefit in older persons. A prospective study of 997 persons older than 70 years, for example, provided evidence to contest the association between blood cholesterol level and incidence of CHD or death due to CHD.<sup>1</sup>Until the efficacy of lowering lipid levels is supported by
Wegener's granulomatosis
Authors: M. C. Sneller
Journal: JAMA (1995)

<h3>SELECTED CASES</h3><h3>Patient 1</h3> A previously healthy 20-year-old man experienced the subacute onset of an influenzalike illness characterized by diffuse arthralgias, malaise, fever, nonproductive cough, nasal congestion, epistaxis, and frontal headaches. His symptoms were unresponsive to decongestants and multiple courses of oral antibiotics. During the next several weeks he developed pain and swelling over the bridge of his nose and migratory pain and swelling of multiple joints. Because of persistent epistaxis he consulted an otolaryngologist, who noted diffusely inflamed nasal mucosa and performed a biopsy, which showed acute and chronic inflammation. The patient was referred to the National Institutes of Health 4 months after his symptoms began. Laboratory evaluation showed a white blood cell count of 10.8×10<sup>9</sup>/L, hemoglobin of 126 g/L, erythrocyte sedimentation rate of 71 mm/h, creatinine of 80 μmol/L (0.90 mg/dL), and a normal urinalysis. Radiographic studies revealed pansinusitis and a nodule in the upper lobe
Mesenchymal Stem Cells for Treatment of Severe Acute Graft-Versus-Host Disease.
Authors: Katarina Le Blanc, Francesco Frassoni, Lynne Ball, Edoardo Lanino, Berit Sundberg, Lena Lonnies, Helene Roelofs, Giorgio Dini, Andrea Bacigalupo, Franco Locatelli, Willem F. Fibbe, Olle Ringden
Journal: Blood (2006)
A man with a fine talent for idleness
Authors: G. W. Corner
Journal: JAMA (1967)

Thirty years ago as a college sophomore intending to study medicine, I enrolled in a course on the English drama. For the inevitable term paper, I found "Medicine in the Modern Drama" a fascinating and rewarding subject. I explored the works of such then well-known playwrights as Ibsen, Shaw, Guitry, Romains, Schnitzler, Kingsley, and Howard. Since there was enough material for a book, I could prune and refine my paper rather than struggle to attain adequate length. That essay constituted my first publication.<sup>1</sup> I still regard that first publication with affection. The judgements still seem sound, and there is little that I would change as the result of greater maturity. However, now I can see more clearly that the plays I discussed fall into five distinct categories. Plays for the stage, movies, and television utilize medicine as part of social criticism, or satire, or history, or medical tract, or
Book Listings
Journal: Annals of Internal Medicine (2001)

Book Listings2 January 2001Book ListingsSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-134-1-200101020-00001 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail CardiologyBasic Electrocardiography in Ten DaysDR Ferry. 266 pages. New York: McGraw-Hill; 2001. $40.00. ISBN 0071352929. Order phone 800-262-4729.Cardiac Pacing and Defibrillation: A Clinical ApproachDL Hayes, MA Lloyd, and PA Friedman. 600 pages. Armonk, NY: Futura; 2000. $89.00. ISBN 087993462X. Order phone 800-877-8761.Cardiovascular Medicine2nd edition. JT Willerson and JN Cohn, eds. 2344 pages. Philadelphia: WB Saunders; 2000. $165.00. ISBN 0443070008. Order phone 800-545-2522.Dispersion of Ventricular Repolarization: State of the ArtSB Olsson, JP Amlie, and S Yuan, eds. 330 pages. Armonk, NY: Futura; 2000. $125.00. ISBN 0879934581. Order phone 800-877-8761.Handbook of Contrast Echocardiography: Left Ventricular Function and ... Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 2 January 2001Volume 134, Issue 1Page: B1KeywordsBurnsHealth information technologyPrevention, policy, and public health ePublished: 2 January 2001 Issue Published: 2 January 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
P039/O03 Circulating follicular helper T cells are increased in systemic sclerosis and promote plasmablast differentiation through the IL-21 pathway which can be inhibited by ruxolitinib
Authors: L Ricard, V Jachiet, F Malard, Y Ye, N Stocker, S Rivière, P Senet, J-B Monfort, O Fain, M Mohty, B Gaugler, A Mekinian
Journal: Annals of the Rheumatic Diseases (2019)

<h3>Career situation of first and presenting author</h3> Student for a master or a PhD <h3>Introduction</h3> Systemic sclerosis (SSc) is an autoimmune disease characterized by widespread fibrosis, microangiopathy and autoantibodies. Follicular helper T (Tfh) cells CD4<sup>+</sup>CXCR5<sup>+</sup>PD-1<sup>+</sup> cooperate with B lymphocytes to induce the differentiation of plasmocytes secreting Immunoglobulins (Ig). Circulating Tfh (cTfh) cells are increased in several autoimmune diseases.<sup>1</sup> Tfh cells can infiltrate the skin of SSc patients, and induce fibrosis <i>in vitro</i>.<sup>2</sup> <h3>Objectives</h3> The aim of this study was to perform a quantitative and functional analysis of cTfh cells in SSc. <h3>Methods</h3> Using flow cytometry, we analyzed cTfh cells from 52 SSc patients with no immodulotary treatment and 38 healthy controls (HC). <i>In vitro</i> coculture experiments of sorted cTfh and B cells from 13 SSc patients and 6 HC were performed for functional analysis. IgG and IgM production were measured by ELISA. BCL-6, Blimp-1, CXCL13 and IL-21 expression were analyzed by RTqPCR. <h3>Results</h3> We observed that cTfh cell numbers are increased in SSc patients compared with HC. Furthermore, the increase in cTfh cells was more potent in patients with severe forms of SSc such as diffuse SSc and in the presence of arterial pulmonary hypertension. cTfh cells from SSc patients present an activated Tfh phenotype, with high expression of BCL-6 and increased capacity to produce IL-21 in comparison to HC. In vitro, cTfh cells from SSc patients had higher capacity to stimulate the differentiation of CD19<sup>+</sup>CD27<sup>+</sup>CD38<sup>hi</sup> B cells and their secretion of IgG and IgM through the IL-21 pathway than cTfh cells from HC. Blocking IL-21 or using the JAK1/2 inhibitor ruxolitinib reduced the Tfh cells9 capacity to stimulate the plasmablasts and Ig production. <h3>Conclusions</h3> Circulating Tfh cells are increased in SSc and correlate with SSc severity. The IL-21 pathway or JAK1/2 blockade by ruxolitinib could be a promising strategy in the treatment of SSc. <h3>References</h3> Crotty S. T follicular helper cell differentiation, function, and roles in disease. <i>Immunity</i> 2014;41(4):529-42. Taylor DK, Mittereder N, Kuta E, Delaney T, Burwell T, Dacosta K, <i>et al</i>. T follicular helper-like cells contribute to skin fibrosis. <i>Sci Transl Med</i> 2018;10(431). <h3>Acknowledgements</h3> This work was supported by the Aterhit foundation and received grants from 9Groupe Francophone de Recherche sur la Sclérodermie' (GFRS). <h3>Disclosure of Interest</h3> None declared
Sauce, pickles, and champagne
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An Introduction to Clinical Surgery: Surgical Wherefores and Therefores: A Reasoned Explanation of Surgical Note-Taking
Journal: JAMA (1946)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal