tbuckley/cabot-search huggingface dataset:
THU0568 Anakinra Treatment in Patients with Familial Mediterranean Fever: A Single-Center Experience
Authors: S. Ugurlu, B. Ergezen, H. Ozdogan
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Approximately 5 to10% of FMF patients do not respond to colchicine treatment and/or intolerant to colchicine because of side effects. Several case reports and case series have pointed out the efficacy of IL-1 blockade in colchicine resistant FMFsubgroup. <h3>Objectives</h3> To review the patients followed in our center with FMF who received anakinra, an anti IL-1 receptor antagonist, because of insufficient colchicine response. <h3>Methods</h3> FMF patients who were treated with anakinra were retrospectively reviewed with regard to indication, effect on disease activity and acute phase response, adverse events. Patient global assessment was recorded before and after anakinra treatment. <h3>Results</h3> There were 30 FMF patients with FMF who were treated with anakinra for various indications (amyloidosis in 7, colchicine resistant recurrent febrile attacks in 19, colchicine related side effects in 4). The mean age of this group was 36.34±11.64 years. The mean duration of the disease was 23.93±12 years. There were various co-existing pathologies among this study group like multiple sclerosis (1), ankylosing spondylitis (1), SLE (1), Behçet9s disease (1), low grade lymphoma (1) and PAN (2). Four patients were pregnant. The mean colchicine dose was 2,08±0,5 mg/d. The mean duration of anakinra treatment was 13,5±12,93 months. Twenty three patients reported no attacks after anakinra treatment whereas 5 patients reported at least 50% decrease in the attack frequency. Mean patient global assessment decreased from 8,60±2,3 to 1,92±2,7 under anakinra treatment (p=0.001). Among the 7 patients with amyloidosis, anakinra was stopped in 2 patients because of increased proteinuria. However, a significant decrease in proteinuria was detected in 3 patients. One patient developed severe injection site reaction and therefore the drug was stopped. Overall, 4 of our patients with amyloidosis are still on Anakinra treatment. Three patients had a severe allergic reaction (severe disseminated rash in 1 patient and severe injection site reaction in 2 patients) and therefore the drug was stopped. Two patients had infections (one had genital warts and urinary tract infection, the other had sinusitis and folliculitis) and the treatment was terminated. One of our patients reported that her psoriatic lesions got worse on anakinra. Twenty two patients reported no adverse events during the treatment. <h3>Conclusions</h3> Anakinra was effective in controlling the symptoms in colchicine-resistant FMF cases. It was also effective in FMF related amyloidosis. The major cause of treatment termination was injection site reactions. Anakinra seems to be an effective alternative in patients who have insufficient response to colchicine. <h3>Disclosure of Interest</h3> None declared
Effects of weight loss vs aerobic exercise training on risk factors for coronary disease in healthy, obese, middle-aged and older men. A randomized controlled trial
Authors: L. I. Katzel
Journal: JAMA (1995)

<h3>Objective.</h3> —To compare the effects of weight loss vs aerobic exercise training on coronary artery disease risk factors in healthy sedentary, obese, middle-aged and older men. <h3>Design.</h3> —Randomized controlled trial. <h3>Subjects.</h3> —A total of 170 obese (body mass index, 30±1 kg/m<sup>2</sup>[mean±SEM]), middle-aged and older (61 ±1 years) men. <h3>Interventions.</h3> —A 9-month diet-induced weight loss intervention, 9-month aerobic exercise training program, and a weight-maintenance control group. <h3>Main Outcome Measures.</h3> —Change in body composition, maximal aerobic capacity (Vo<sub>2</sub>max), blood pressure, lipoprotein concentrations, and glucose tolerance. <h3>Results.</h3> —Forty-four of 73 men randomized to weight loss completed the intervention and had a 10% mean reduction in weight (-9.5±0.7 kg;<i>P</i>&lt;.001), with no change in Vo<sub>2</sub>max. Forty-nine of 71 men randomized to aerobic exercise completed the intervention, increased their Vo<sub>2</sub>max by a mean of 17% (<i>P</i>&lt;.001), and did not change their weight, whereas the 18 men who completed in the control group had no significant changes in body composition or Vo<sub>2</sub>max. Weight loss decreased fasting glucose concentrations by 2%, insulin by 18%, and glucose and insulin areas during the oral glucose tolerance test (OGTT) by 8% and 26%, respectively (<i>P</i>&lt;.01). By contrast, aerobic exercise did not improve fasting glucose or insulin concentrations or glucose responses during the OGTT but decreased insulin areas by 17% (<i>P</i>&lt;.001). In analysis of variance, the decrement in fasting glucose and insulin levels and glucose areas with intervention differed between weight loss and aerobic exercise when compared with the control group (<i>P</i>&lt;.05). Similarly, weight loss but not aerobic exercise increased high-density lipoprotein cholesterol levels (+13%) and decreased blood pressure compared with the control group. In multiple regression analyses, the improvement in lipoproteins and glucose metabolism was related primarily to the reduction in obesity. <h3>Conclusions.</h3> —These results suggest that weight loss is the preferred treatment to improve coronary artery disease risk factors in overweight, middle-aged and older men. (<i>JAMA</i>. 1995;274:1915-1921)
Administrative medicine
Authors: R. M. Heyssel
Journal: JAMA (1990)

Career opportunities for physicians in health care system management and their changing preparation for these roles have been previously described.<sup>1</sup>Today, the trend for physicians to enter active management roles is, if anything, accelerated. Between 1978 and 1988, the number of physicians classified as "administrative MDs" increased from 11 858 to 14 536, according to the American Medical Association's Physician Masterfile (Vicky Carlson, oral communication, February 26, 1990). The American College of Physician Executives reports a membership of more than 5000 (Robin Doty, oral communication, March 7,1990). Physician-managers have found new opportunities in administration as the numbers of people enrolled in one or another managed-care organization have continued to increase. Managed-care programs include health maintenance organizations, preferred provider organizations, and managed fee-for-service entities. In 1980, the managed-care field was dominated almost exclusively by health maintenance organizations; at that time, 236 health maintenance organizations had 9.1 million enrollees. By 1989,
Latex glove allergy. A survey of the US Army Dental Corps
Authors: Z. T. Berky
Journal: JAMA (1992)

<h3>Objective.</h3> —To assess the prevalence of latex glove allergy in a population of health care providers (dentists) with a high occupational exposure to latex gloves. <h3>Design.</h3> —A survey instrument was distributed to all active-duty dental officers in the US Army (n=1628). The survey was designed to identify those individuals who had symptoms of allergy to latex gloves. <h3>Setting.</h3> —US Army dental facilities worldwide. <h3>Results.</h3> —The response rate to the survey was 64% (n=1043). There were 143 (13.7%) responses indicating latex glove allergy. If nonrespondents were assumed to be allergy-free, the prevalence rate would be 8.8%. <h3>Conclusion.</h3> —Latex allergy, as ascertained by self-report in this survey, appears to have a substantial prevalence in this health care provider population. (<i>JAMA</i>. 1992;268:2695-2697)
Biocultural perspectives on women's health.
Journal: Environmental Health Perspectives (1997)

Forum has its weaknesses."According to Jansen, studies sponsored by Southern Company and others indicate that the OTAG model overestimates the amount of isoprene by a large degree, compared with the amount actually found in the air."This finding demonstrates that the [OTAG] model over- estimates the amount of ozone reduction one gets from a [NOx] reduction and underestimates the amount of reduction one gets from a VOC reduction," he says.NOx is the limiting factor in ozone production if the VOC level is high.Large NOx reductions would mean con- trols on utilities, many of which burn huge amounts of coal."That could be very costly, and people are going to be disappointed in the actual result," Jansen says.He also argues that research done for his company finds that in a number of major southern cities, ozone levels that exceed current standards are caused primarily by local, not regional, emissions.
比较生物制剂依奇珠单抗与其他两种治疗银屑病的药物富马酸酯和甲氨蝶呤的试验
Authors: K. Reich, M. Augustin, D. Thaçi, A. Pinter, A. Leutz, C. Henneges, E. Schneider, A. Schacht, M. Dossenbach, U. Mrowietz
Journal: British Journal of Dermatology (2020)

斑块型银屑病是一种皮肤病,可引起红色、鳞屑性皮肤斑块。它是一种慢性疾病,这意味着它一般会长期存在。用于治疗斑块型银屑病的药物包括一种称为甲氨蝶呤的药物,在一些欧洲国家,还包括一种称为富马酸酯 (FAE) 的药物。 近年来,被称为生物制剂的新型强效药物被用于治疗银屑病。依奇珠单抗是治疗中重度斑块型银屑病的生物制剂之一。它是一种抗体,意味着机体免疫系统用来抵御疾病的一类蛋白质。 依奇珠单抗可结合并中和白介素‐17A,白介素‐17A 是一种参与皮肤炎症反应并引起银屑病症状的蛋白。以这种方式阻断白介素‐17A 活性是治疗银屑病等疾病的有用方法。 本研究的目的是在一项在慢性中重度斑块型银屑病患者中开展的随机对照试验 (RCT) 中比较依奇珠单抗与甲氨蝶呤和 FAE 的疗效。RCT 试验是指患者被随机分配到正在研究的其中一种药物的治疗组,也有不接受任何正在被比较治疗的对照组。 使用银屑病面积和严重程度指数 (PASI) 评价疗效(治疗成功),PASI 是银屑病病灶(受累皮肤斑片)发红、增厚、鳞屑和程度的指标。PASI 75 表示患者的 PASI 评分自研究开始后至少改善 75%。 德国 162 例成人患者被随机分配到三种治疗中的一种。24 周后,90.7% 接受依奇珠单抗治疗的患者达到 PASI 75,而接受甲氨蝶呤治疗的患者为 70.4%,接受 FAE 治疗的患者为 22.2%,表明依奇珠单抗的治疗成功率更高。 此外,与接受甲氨蝶呤或 FAE 治疗的患者相比,接受依奇珠单抗治疗的达到 PASI 90 和 PASI 100(表明其 PASI 评分分别改善 90% 和 100%)的患者数量显著更多,皮肤病生活质量指数显著改善(在试验期间的多个时间点测量,可测量患者的生活质量)。 与 FAE 相比,依奇珠单抗组因不良健康事件(不良副作用)终止治疗的患者百分比较低 (3.7%vs 38.5%),而依奇珠单抗和甲氨蝶呤组之间相似 (3.7%vs 0.0%)。 这些结果证实了依奇珠单抗作为中重度斑块型银屑病患者一线治疗的获益优于甲氨蝶呤和 FAE,并可能有助于完善未来的治疗指南。 本摘要涉及研究:一项在未接受过系统治疗的中重度斑块型银屑病患者中比较依奇珠单抗与富马酸酯和甲氨蝶呤疗效和安全性的为期 24 周、多中心、随机、开放标签、平行组研究
The Physician's Wife; and the Things that Pertain to Her Life.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Motke
Authors: J Herman
Journal: Annals of Internal Medicine (1993)

On Being a Doctor15 October 1993MotkeJoseph Herman, MDJoseph Herman, MDBen-Gurion University of the Negev, Beer-Sheva, Israel.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-8-199310150-00012 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Most of us have at least one candidate for my most unforgettable patient; the more fortunate may even have several. Mine is Motke and I am not sure if it would have been any easier to forget him had I not been his doctor. He was one of those people who embody a whole way of being; he stood over and against the materialistic, communal idealism of those among whom he lived. There was an air of saintliness about him but he would have laughed at the description, for he was an agnostic. He walked with a limp from childhood ... Author, Article, and Disclosure InformationAuthors: Joseph Herman, MDAffiliations: Ben-Gurion University of the Negev, Beer-Sheva, Israel.Corresponding Author: Joseph Herman, MD, 42 Harav Uzziel Street, Bayit V'gan 96424, Jerusalem, Israel. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 October 1993Volume 119, Issue 8Page: 851-852KeywordsAnginaEmotionsHospital medicineMyocardiumShockStable coronary artery diseaseSurgeonsTasteTemperatureTransplantation ePublished: 15 August 2000 Issue Published: 15 October 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Blood Lead Levels in the US Population
Authors: Debra J. Brody
Journal: JAMA (1994)

<h3>Objective.</h3> —To determine mean blood lead levels and their sociodemographic correlates in the US population. <h3>Design.</h3> —Nationally representative cross-sectional health examination survey that included measurements of venous blood lead. <h3>Participants.</h3> —A total of 13201 persons aged 1 year and older examined during phase 1 of the third National Health and Nutrition Examination Survey (1988 to 1991). <h3>Results.</h3> —The overall mean blood lead level for the US population was 0.14 μmol/L (2.8 μg/dL). Blood lead levels were consistently higher for younger children than for older children, for older adults than for younger adults, for males than for females, for blacks than for whites, and for central-city residents than for non—central-city residents. Other correlates of higher blood lead levels included low income, low educational attainment, and residence in the Northeast region of the United States. National estimates for children 1 to 5 years of age indicate that 8.9%, or approximately 1.7 million children, have blood lead levels 0.48 μmol/L (10 μg/dL) or greater. These levels are high enough to be of health concern under 1991 Centers for Disease Control and Prevention guidelines. <h3>Conclusions.</h3> —The low overall mean blood lead levels demonstrate a major public health success in primary prevention efforts. However, exposure to lead at levels that may adversely affect the health of children remains a problem especially for those who are minority, urban, and from low-income families. Strategies to identify the most vulnerable risk groups are necessary to further reduce lead exposure in the United States. (<i>JAMA</i>. 1994;272:277-283)
Eighth World Congress of Gynecology and Obstetrics
Journal: JNCI Journal of the National Cancer Institute (1975)

Journal Article Eighth World Congress of Gynecology and Obstetrics Get access JNCI: Journal of the National Cancer Institute, Volume 55, Issue 5, November 1975, Page 1259, https://doi.org/10.1093/jnci/55.5.1259-d Published: 01 November 1975
A Nutrition Program and Teaching Outline Developed for Use in the Health Centers and Clinics of the Division of Child Hygiene, Department of Public Health, Philadelphia
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Travel Notes.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Treatment of Lower Extremity Superficial Thrombophlebitis
Authors: Marcello Di Nisio, Iris Wichers, Saskia Middeldorp
Journal: JAMA (2018)

Which treatments for lower extremity superficial thrombophlebitis (ST) are associated with lower rates of venous thromboembolic events (VTEs) vs placebo?A dose of 2.5 mg of fondaparinux administered subcutaneously once daily for 45 days is associated with fewer cases of symptomatic VTE without an increase in major bleeding vs placebo. Low-molecular-weight heparin (LMWH) and nonsteroidal anti-inflammatory drugs (NSAIDs) are associated with lower rates of ST extension or recurrence vs placebo, but data regarding symptomatic VTE remain inconclusive. Oral rivaroxaban requires further evaluation.
Clinical, immunologic, and serologic findings in men at risk for acquired immunodeficiency syndrome. The San Francisco Men's Health Study
Authors: W. Lang
Journal: JAMA (1987)

Forty-nine percent of homosexual/bisexual men were positive for antibody to the human immunodeficiency virus (HIV) in a population-based probability sample of 1034 single men recruited from San Francisco. All heterosexual men were negative. Among seropositive men, marked lymphadenopathy was present in 29%, and 16% had at least two other symptoms or signs suggestive of HIV infection. However, lymphadenopathy alone failed to indicate severity of immune impairment. The occurrence of two or more clinical signs and symptoms, except for marked lymphadenopathy, correlated with HIV infection, diminished skin test reactivity, and reduction in Leu 3a T cells. Twenty-nine percent of seropositive men had fewer than 400 absolute Leu 3a T helper cells per microliter (&lt;0.4×10<sup>9</sup>/L). Seronegative homosexual/bisexual men did not differ from heterosexual men in any clinical or laboratory variables except for increased numbers of suppressor Leu 2a T suppressor cells per microliter. (<i>JAMA</i>1987;257:326-330)
Bordering on Environmental Disaster
Authors: Charles W. Schmidt, Jeffry Scott
Journal: Environmental Health Perspectives (2000)

Millions of people live on the U.S.-Mexico border, drawn by employment opportunities from industry and agriculture, and booming growth is expected to continue in the coming decades. But the influx of people has long outstripped the capacity of border towns and cities to provide for their citizens, and a large percentage of the population lives in sprawling, underserviced shantytowns. Although investment in environmental infrastructure on both sides has led to improvements, shortages among necessities such as drinking water, wastewater treatment, and solid waste disposal are at crisis levels. In addition, a host of diseases including gastrointestinal infections, asthma, tuberculosis, multiple myeloma, systemic lupus erythematosus, hepatitis A, neural tube defects, and lead poisoning have been linked to environmental conditions on the border. Ongoing binational studies are attempting to define the breadth of the public and environmental health crisis and find ways to help make the border a healthier place.
Issue Highlights
Authors: Francis K.L. Chan
Journal: Clinical Gastroenterology and Hepatology (2014)

Routine use of iron supplements in pregnancy is recommended in affluent countries. This recommendation, however, has been challenged in this issue of Clinical Gastroenterology and Hepatology. In a prospective cohort study of 78,846 children in Norway by Størdal et al, it was found that using iron supplements during pregnancy was associated with a modest but significant increased risk of celiac disease (4.65/1000 children whose mothers took iron supplements during pregnancy compared to 3.15/1000 children whose mothers did not [odds ratio, 1.33; 95% confidence interval, 1.05–1.68; P = .019]).
Oestrogens and thromboembolism.
Journal: BMJ (1970)

PointersPill and Thrombosis: Association between coronary thrombosis and oral contraceptives is reported (pp.203 and 210), and evidence for relation between risk of thrombosis and com- position of pill is analysed (p.210); Committee on Safety of Drugs issues statement (p.231).Leader this page.Drug Abuse: Treatment ought to be concerned not only with methods but with the organiza- tion of treatment services (p.195).Blood Clotting and Childbirth: Changes in the clotting mechanisms of the blood in pregnancy and childbirth are analysed, and they may explain the increased liability to thrombosis in the puerperium (p.200).Bronchitis: The disease in adults depends partly on its beginning in childhood, when it is related to social class, residence in South Wales, and, among children of semiskilled and unskilled workers, air pollution (p.213).
IMMUNITY.CHAPTER XXVI.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Site of action of intrathecal morphine.
Authors: J S Crawford
Journal: BMJ (1980)

fore be used when a beta-blocking agent is required in diabetics prone to hypoglycaemia.However, with these drugs also patients should be informed that institution of treat- ment may modify the normal hypoglycaemic symptoms.Additionally, until further ex- perience has been gained we think that special care should be exercised with any of these drugs in diabetics with clear autonomic neuropathy, where both symptoms and recovery may be further compromised.