SICKLEMIA
Authors: N ENDE, P PIZZOLATO, J ZISKIND
Journal: Annals of Internal Medicine (1955)

Article1 May 1955SICKLEMIANORMAN ENDE, M.D., PHILIP PIZZOLATO, M.D., JOSEPH ZISKIND, M.D., F.A.C.P.NORMAN ENDE, M.D.Search for more papers by this author, PHILIP PIZZOLATO, M.D.Search for more papers by this author, JOSEPH ZISKIND, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-42-5-1065 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSickle cell anemia has long been known to produce severe clinical manifestations. Only recently, however, has it been accepted that the sickle cell trait per se, or sicklemia, is also capable of producing clinical symptoms and pathologic findings.1 Although prior to 1940 some cases of sicklemia had been reported2 which showed clinical findings with no anemia, it was not until that year that Bauer3 introduced the idea that the anemic picture was but one manifestation of sickle cell disease.The most recent combined surveys show a 9.0% incidence of sickling4in the Negro population of the United States. Despite these...Bibliography1. Wintrobe MM: Clinical hematology, 3d Ed., 1951, Lea and Febiger, Philadelphia. Google Scholar2. Campbell EH: Acute abdominal pain in sickle cell anemia, Arch. Surg. 31: 607, 1935. CrossrefGoogle Scholar3. Bauer J: Sickle cell disease, Arch. Surg. 41: 1344, 1940. CrossrefGoogle Scholar4. Margolies MP: Sickle cell anemia, Medicine 30: 357, 1951. CrossrefMedlineGoogle Scholar5. GreenConley TWCL: Occurrence of symptoms of sickle cell disease in the absence of persistent anemia, Ann. Int. Med. 34: 849, 1951. LinkGoogle Scholar6. CanbyCarpenterEllmore CBGLF: Drepanocytosis (sicklemia) and an apparently acute surgical condition of the abdomen, Arch. Surg. 48: 123, 1944. CrossrefGoogle Scholar7. Sullivan BH: Danger of aeroplane flight to persons with sicklemia, Ann. Int. Med. 32: 339, 1950. Google Scholar8. AbelBrown MSCR: Sickle cell anemia with severe hematuria simulating renal neoplasm, J. A. M. A. 136: 624, 1948. CrossrefMedlineGoogle Scholar9. GoodwinAlstonSimons WEEFJH: Hematuria and sickle cell disease, J. Urol. 63: 79, 1950. CrossrefMedlineGoogle Scholar10. RyanFuller JERH: Hemorrhagic manifestations of sickle cell disease, U. S. Armed Forces M. J. 2: 623, 1951. MedlineGoogle Scholar11. ThompsonWagnerMacleod RKJACM: Sickle cell disease: report of a case with cerebral manifestations in absence of anemia, Ann. Int. Med. 29: 921, 1948. LinkGoogle Scholar12. BauerFisher JLJ: Sickle cell disease with special regard to its non-anemic variety, Arch. Surg. 47: 553, 1943. CrossrefGoogle Scholar13. Pratt-ThomasSwitzer HRPK: Sicklemia: its pathological and clinical significance, South. M. J. 42: 376-844 (May) 1949. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: NORMAN ENDE, M.D.; PHILIP PIZZOLATO, M.D.; JOSEPH ZISKIND, M.D., F.A.C.P.Affiliations: New Orleans, Louisiana*Received for publication September 7, 1954.From the Clinical Laboratory, Veterans Administration Hospital, and the Departments of Pathology, Tulane University School of Medicine and Louisiana State University School of Medicine, New Orleans, Louisiana.†Sponsored by the Veterans Administration and published with the approval of the Chief Medical Director. The statements and conclusions published by the authors are a result of their own study and do not necessarily reflect the opinion or policy of the Veterans Administration. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byProspective Brain Imaging Evaluation of Children with Sickle Cell Trait: Initial ObservationsStroke in a 9-year-old with sickle cell traitLarge-vessel occlusion in sickle cell disease: Pathogenesis, clinical consequences, and therapeutic implicationsCerebral infarction in sickle cell traitIschemic Colitis Complicating Sickle Cell CrisisSickle Cell Trait and Multiple Cerebral InfarctionsThe morbidity of sickle cell traitOcclusion of Large Cerebral Vessels in Sickle-Cell AnemiaNeurological Manifestations in Sickle-Cell Disease With a Review of the Literature and Emphasis on the Prevalence of HemiplegiaBARRY A. PORTNOY, M.D., JOHN C. HERION, M.D.Spinal cord infarction associated with the sickle cell traitAnterior and Posterior Hypopituitarism Associated with Sickle Cell TraitROBERT A. PASTURE, JAMES W. ANDERSON, ROBERT H. HERMANPrimary cardiomyopathy in nonanemic patientsAseptic necrosis of the femoral heads in sickle-A hemoglobin diseaseSickle cell states and cardiomyopathySickle-Cell Trait and Central Retinal-Artery OcclusionThe influence of hemoglobinopathies on reproductionSickle Cell Trait and Superior Longitudinal Sinus ThrombosisERIC A. SCHENK, M.D.Avascular Necrosis of the Femoral Head Associated with Sickle Cell Trait (AS Hemoglobin)RALPH G. RATCLIFF, M.D., MELVYN D. WOLF, M.D.Fatal Intravascular Sickling in a Patient with Sickle-Cell TraitSicklemia Complicating Chest SurgeryTHE GENETICS OF HUMAN HAEMOGLOBIN DIFFERENCES: PROBLEMS and PERSPECTIVES 1 May 1955Volume 42, Issue 5Page: 1065-1075KeywordsAnemiaClinical laboratoriesHospital medicinePathology and laboratory medicineSickle cell disease ePublished: 1 December 2008 Issue Published: 1 May 1955 PDF downloadLoading ...