tbuckley/cabot-search huggingface dataset:
A multicentric phase II randomized trial of docetaxel (D) plus enzalutamide (E) versus docetaxel (D) as first-line chemotherapy for patients (pts) with metastatic castration-resistant prostate cancer (mCRPC): CHEIRON study.
Authors: Orazio Caffo, Erica Palesandro, Franco Nole, Donatello Gasparro, Claudia Mucciarini, Michele Aieta, Roberto Iacovelli, Ugo De Giorgi, Sabrina Rossetti, Marco Maruzzo, Lucia Fratino, Cosimo Sacco, Maurizio Nicodemo, Monica Giordano, Donata Sartori, Daniela Scapoli, Elena Verri, Antonello Veccia, Giovanni L. Pappagallo, Massimo Aglietta
Journal: Journal of Clinical Oncology (2019)

5050 Background: D and E demonstrated to be efficacious in the treatment of mCRPC pts. Due to different antitumor mechanism of action of these agents, it could be postulated that their combination can improve disease control. CHEIRON study tried to demonstrate the candidate efficacy of chemo-hormonal combination D+E versus D in mCRPC first-line. Methods: Eligibility criteria included mCRPC diagnosis, ECOG PS ≤ 2, adequate renal, hepatic and hematological functions, no prior treatment for mCRPC. Pts were randomized to receive D 75 mg/m 2 IV d1 q3w plus prednisone 5 mg PO BID for 8 courses alone or plus E 160 mg PO daily for 24 weeks. Stratification criteria were presence of pain and visceral metastases. The primary endpoint of the study was the rate of pts without disease progression (according to PCWG2) at 6 mos after randomization. Results: Between 09/2014 and 10/2017, 246 pts (median age 70 years, range 44-88, pain reported by 54 pts, visceral metastases present in 50 pts) were randomized to DE (120) or D (126). The rate of pts without disease progression at 6 mos was significantly higher in DE arm compared to D arm (89.1% vs 72.8%; p = 0.002). Similarly, a higher proportion of DE pts achieved a PSA reduction ≥ 50% compared to the baseline values compared to the D pts (92% vs 69%; p &lt; 0.0001). No differences were observed in terms of objective response rate. Major haematological toxicities consisted of grade 3-4 neutropenia (13 pts DE – 11 pts D); febrile neutropenia was observed in 10 DE pts and in 6 D pts. At a median follow-up of 24 mos, the median progression free survival was 10.1 mos and 9.1 mos in DE and D arm, respectively (p = 0.01). In DE arm the median overall survival was 33.7 mos compared to 29.6 mos of the standard arm (p NS). Conclusions: The present study was the first phase II randomized trial, which tested the addition of a new generation hormone agent to D compared to D alone. From this data, DE improved the 6-mo disease control with a prolongation of PFS compared to the standard chemotherapy. Clinical trial information: NCT02453009.
Intracellular Signaling Events in CD77-Mediated Apoptosis of Burkitt's Lymphoma Cells
Authors: Samir Taga, Karine Carlier, Zohair Mishal, Corinne Capoulade, Marianne Mangeney, Yann Lécluse, Dominique Coulaud, Cécile Tétaud, Linda Louise Pritchard, Thomas Tursz, Joëlle Wiels
Journal: Blood (1997)
Medicine Preferred (A Modern Play in Three Acts)
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PHYSICAL THERAPY
Authors: MORRIS FISHBEIN
Journal: JAMA (1925)

No doubt the first agents of treatment used by man were those which could be had through simple adaptations of things natural. The application of heat and cold, rubbing and massage, and the use of water and of sunlight are as old as man himself. In the aphorisms of Hippocrates one reads of the uses of such methods; even at that time sound observers seem to have realized that these agents may act for good or for evil. "Heat is suppurative," says one aphorism, "but not in all kinds of sores; but when it is, it furnishes the greatest test of their being free from danger. It softens the skin, makes it thin, removes pain, soothes rigor, convulsions and tetanus." But again, "Heat produces the following bad effects on those who use it frequently: enervation of the fleshy parts, impotence of the nerves, torpor of the understanding, hemorrhages, deliquia, and
Abstract 494: Immune cell screen of tumor micro environment of PD-L1 in positive/negative bladder cancer, melanoma, and lung cancer
Authors: Rachel Gonzalez, Wei Fu, Evelin Logis, Casey Chen, Tiffany Cone, Sonia Merritt, Yiran Wang, Guanli Wang, Donghui Ma
Journal: Cancer Research (2019)

Abstract PD-L1/PD1 immune therapy has been very successful for some patients. Treatment is usually based on PD-L1 tumor expression levels in tumors; however some patients with positive tumors have shown no response to therapy. Recent, clinical trials have shown that treating patients with more than one immune therapy target results in better outcome suggesting the importance of understanding PD-L1 tumor micro environment. In this study, we look at a number of immune cell markers with PD-L1 expression to see if patterns of the immune cells infiltrating the tumor micro environment vary. PD-L1 expression in the tumors was assessed by multiple PD-L1 antibodies since no single PD-L1 antibody has been FDA approved for all tumor types. Immuno-histo chemistry (IHC) screen used 2 recombinant rabbit monoclonal antibodies (clone OR-5E3 and OR-5H8), one mouse anti PD-L1 clone UMAB229, and the FDA approved antibodies clones (SP142 and 28-8). Immune cell markers used in the IHC screen were CD3, CD8A, CD20, CD68, FOXP3, LAG3 and TIM3. The screen was done on sequential sections of bladder, melanoma, and lung tumors. Variation existed between five PD-L1 antibodies in their sensitivity and specificity to detect PD-L1 in the different tumor types; however, the differences were usually associated with the ability to detect low expressing tumors. Immune cell markers CD3, CD8A, CD20, CD68, FOXP3, LAG3, and TIM3 cell markers all produced strong staining if positive cells were present; however, they vary in number and distribution pattern throughout the three types of tumor. For example, when lung or bladder tumors presented strong PD-L1 staining at the edge of the tumor they often had a number of CD3E or CD8A immune positive cells present, this was not the case for CD20 which were foci clusters or scatter through the tumors. FOXP3 and CD68 staining were scarce event in all three tumor types. Although this study was limited to small sample size 10 tumors each it did show differences in the amount and distribution of immune cells in the 3 different types of tumor positive for PD-L1 expression. Citation Format: Rachel Gonzalez, Wei Fu, Evelin Logis, Casey Chen, Tiffany Cone, Sonia Merritt, Yiran Wang, Guanli Wang, Donghui Ma. Immune cell screen of tumor micro environment of PD-L1 in positive/negative bladder cancer, melanoma, and lung cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 494.
LOUIS PASTEUR—BORN DECEMBER 27, 1822
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CHOLERA.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Headache, St. Louis
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cervical Radiculitis
Authors: David Goldberg
Journal: JAMA (1974)

<h3>To the Editor.—</h3> Neck pain is directly related to television. When first questioned about the time they spend watching television, patients usually belittle the insinuation that they might be spending leisure time foolishly. "Idiot box," "boob tube," and "stupid screen" are responsible for this allegation. After a terribly fatiguing day at work, one must relax. Some will lie on the couch, head resting on arm, and neck laterally flexed. Others will sit in reclining chairs, with the neck forcibly flexed, to focus on a screen a few inches above the floor. Some watch television lying in bed, night after night, the neck sharply flexed, propped by pillows or tilted against the headboard. <h3>Symptoms.—</h3> Origin of symptoms is insidious. Some relate to hindsight of minor trauma. Or, original trauma persists because of repetitive strain associated with improper viewing. <h3>Physical Findings.—</h3> Objective abnormalities are sparse, such as slight spasm of paravertebral musculature.
From the Centers for Disease Control and Prevention. FDA approval of a haemophilus b conjugate vaccine combined by reconstitution with an acellular pertussis vaccine
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CONSTITUTIONALITY OF GIVING EXAMINERS SUPERVISION OVER MEDICAL COLLEGES.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Do Medical Residents Experience Burnout?
Journal: Annals of Internal Medicine (2002)

Summaries for Patients5 March 2002Do Medical Residents Experience Burnout?Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-136-5-200203050-00003 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Burnout is a loss of interest in one's work and a feeling of “just going through the motions.” Physicians who are burned out are cynical and exhausted emotionally; they also feel they are working hard but accomplishing little. Burnout can affect people in helping professions, and it is associated with decreased job performance, reduced job commitment, and low career satisfaction. Physicians are at high risk for burnout. Their work is stressful, and they may try to do too much. They constantly address other people's problems and may ignore ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Burnout and Self-Reported Patient Care in an Internal Medicine Residency Program.” It is in the 5 March 2002 issue of Annals of Internal Medicine (volume 136, pages 358-367). The authors are TD Shanafelt, KA Bradley, JE Wipf, and AL Back.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians–American Society of Internal Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoBurnout and Self-Reported Patient Care in an Internal Medicine Residency Program Tait D. Shanafelt , Katharine A. Bradley , Joyce E. Wipf , and Anthony L. Back Metrics 5 March 2002Volume 136, Issue 5Page: I-29KeywordsAlcohol consumptionAlcoholsEmotionsFatiguePatientsQuestionnairesResidencySubstance abuse ePublished: 5 March 2002 Issue Published: 5 March 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
New questions on genomic instability.
Journal: Environmental Health Perspectives (1997)

Forum areas and gaps that the conference identified as priorities for the 21st century.Among exciting future research projects to emerge from the conference, Kenneth Olden, director of the NIEHS, unveiled his plan to create the Environmental Genome Project, a broad, multicenter effort to learn how genetic variances in individuals and populations account for differences in sus- ceptibility to diseases with environmental triggers.The project would sequence about 200 known environmental disease suscepti- bility genes from five main categories: genes controlling the distribution and metabolism of toxicants, genes for the DNA repair pathways, genes for the cell cycle, genes for the metabolism of nucleic acid precursors, and genes for signal transduction systems controlling expression of genes in other classes.
Effect of low glycaemic index or load dietary patterns on glycaemic control and cardiometabolic risk factors in diabetes: systematic review and meta-analysis of randomised controlled trials
Journal: BMJ (2021)

Effect of low glycaemic index or load dietary patterns on glycaemic control and cardiometabolic risk factors in diabetes: systematic review and meta-analysis of randomised controlled trialsIn this paper by Chiavaroli and colleagues (BMJ 2021;374:n1651
Experimental Hydronephrosis.
Authors: S R GREENBERG
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Patient-initiated laboratory testing: no gatekeeper, no kidding
Journal: JAMA (1991)

<h3>To the Editor.—</h3> My first response to Dr Soloway's<sup>1</sup>Commentary was that this was some sort of medical spoof. This form of medical practice gives a new meaning to the term<i>catastrophic care</i>! Dr Soloway tells us about the proposed regulations whereby Medicare or Medicaid recipients could order tests on themselves as long as the expense is not billed to Medicare or Medicaid. But think of the expense involved in following up on the results of these tests. This will certainly be billed to Medicare, Medicaid, and everyone else. Rather than "applauding the inevitable," physicians should clench both fists and fight this folly.
Use of Tetracycline Fluorescence in the Detection of Gastric Malignancy
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction
Journal: JNCI Journal of the National Cancer Institute (1986)

In “Murine Lung Carcinogenesis Following Exposure to Ambient Ozone Concentrations,” by C. Hassett, M. G. Mustafa, W. F. Coulson, and R. M. Elashoff, pages 771–777, the chi-square analysis in experiments 1 and 2 were incorrectly computed and, in fact, was not the most appropriate test for assessing statistical significance. Analysis of the relevant data by means of a test of ordered differences, such as the Mann-WhitneyU test corrected for ties, is more appropriate. We have reanalyzed these data accordingly, and the results are as follows: In experiment 1 (0.31 ppm ozone), the lung-tumor response for ozone-exposed animals was not statistically different from that for mice breathing clean air (P< 09); and in experiment 2 (0.50 ppm ozone), there was a greater number of lung tumors in the ozone-exposed group as contrasted with the number in clean-air-breathing mice, and this difference was statistically significant (P<05). Our interpretation of the data regarding synergism between ozone and urethane effects and our overall conclusion that exposure to relatively high ambient concentrations of ozone can increase the incidence of lung adenomas in a sensitive animal model remain unchanged.