tbuckley/cabot-search huggingface dataset:
QUARTERLY SURVEY OF DERMATOLOGICAL LITERATURE.
Journal: British Journal of Dermatology (1918)

British Journal of DermatologyVolume 30, Issue 3 p. 189-194 QUARTERLY SURVEY OF DERMATOLOGICAL LITERATURE ERYTHEMAS, INFLAMMATIONS, ETC First published: July 1918 https://doi.org/10.1111/j.1365-2133.1918.tb13146.xAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Volume30, Issue3July 1918Pages 189-194 RelatedInformation
Converging on RAS
Journal: Cancer Discovery (2017)

Abstract Biologists at the Frederick National Laboratory for Cancer Research have teamed up with computer scientists and physicists at the Department of Energy to tackle the problem of “undruggable” RAS. The goal is to obtain a precise understanding of how RAS is activated by interactions with the plasma membrane; this will be illuminated through supercomputer simulations that build on structural and biochemical studies of RAS.
Michael's Testimonial
Authors: Michael M. Danielson, Karine Dubé
Journal: Annals of Internal Medicine (2019)

Letters2 April 2019Michael's TestimonialMichael M. Danielson and Karine Dubé, DrPHMichael M. DanielsonSan Diego, California (M.M.D.)Search for more papers by this author and Karine Dubé, DrPHUniversity of North Carolina Gillings School of Global Public Health, Chapel Hill, North Carolina (K.D.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L19-0046 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:I thank everyone for the incredible support and positive feedback. This support has been echoed in my private life, from my family and friends to my priest, caretakers, and even strangers. It means a great deal to me and only reinforces my convictions about the importance of keeping California's End of Life Option Act in place and seeing it adjudicated through the court system in favor of myself and others in similar situations to guarantee dignity and compassion at the end of life.Because my ALS is rapidly progressing and I am becoming weaker and more dependent on ... Author, Article, and Disclosure InformationAffiliations: San Diego, California (M.M.D.)University of North Carolina Gillings School of Global Public Health, Chapel Hill, North Carolina (K.D.)Note: Spring marks the start of new beginnings. With dignity, Mr. Danielson took control of his disease and, surrounded by love, stepped into the next season of life. He died peacefully on 1 March, grateful for the ability to remain in control until the end. His testimony to the necessity of the End of Life Option Act remains a beacon to those of us working to destigmatize dying and advocating for those approaching the end of their lives.Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M18-1719. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoMichael's Testimonial Michael M. Danielson and Karine Dubé Michael's Testimonial Stephen Strum Michael's Testimonial Roger S. LaBonte Michael's Testimonial David Killoran Metrics Cited byWhat lessons it might teach us? Community engagement in HIV researchHIV persists throughout deep tissues with repopulation from multiple anatomical sources 2 April 2019Volume 170, Issue 7Page: 511-512KeywordsConflicts of interestDisclosureGratitudeLegislationMortality ePublished: 2 April 2019 Issue Published: 2 April 2019 Copyright & PermissionsCopyright © 2019 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Abstract 2088: Comprehensive CRISPR screening unravel the different mechanisms of IMiDs resistance
Authors: Wenrong Zhou, Tianyu Song, Min Long, Jiye Liu, Qunsheng Ji, Yong Cang
Journal: Cancer Research (2019)

Abstract Immunomodulatory drugs (IMiDs) including lenalidomide and pomalidomide bind cereblon (CRBN) and activate the CRL4CRBN ubiquitin ligase to trigger proteasomal degradation of the essential transcription factors IKZF1 and IKZF3 and multiple myeloma (MM) cytotoxicity. To have a comprehensive understanding of mechanism underlying sensitivity of MM cells to IMiDs, we performed genome-wide CRISPR-Cas9 screening in three MM cell lines: MM.1S, NCI-H929 and OPM2, which showed resistance to IMiDs at different extent. In the published screening in MM.1S cell, we found that CSN9 signalosome complex, a deactivator of Cullin-RING ubiquitin ligase, regulates MM sensitivity to IMiDs by modulating CRBN expression via SCFFbxo7 ubiquitin ligase. With the newly outcome from H929 and OPM2 cells, we identified 5 top ranking genes with more than 2 sgRNAs ranking in the top 5% sgRNAs in all the three cell lines. CRBN was the top ranking gene with all CRBN-targeting sgRNAs ranking in the top 1% enriched sgRNAs. UbE2G1, reported as an E2 of CRL4-CRBN E3 ligase recently, was another top ranking gene in all the three cell lines. DEPDC5, a component of the GATOR1 complex which inhibits mTORC1 pathway, and SLC35G2, classified as a member of nucleotide sugars transporters (NSTs), were also identified in the top list of all the three cell lines, indicating that mTOR pathway as well as Glycosylation may play an important role in the MM cytotoxicity induced by IMiDs. We also identified 76 top genes shared in two of the three cell lines with more than 2 sgRNAs. Taken together, these results provide a research framework leading to distinguish the cancer patients who become resistant to IMiDs therapy. Citation Format: Wenrong Zhou, Tianyu Song, Min Long, Jiye Liu, Qunsheng Ji, Yong Cang. Comprehensive CRISPR screening unravel the different mechanisms of IMiDs resistance [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2088.
Neural Prostheses: Prospects for Decade Ahead
Journal: JAMA (1980)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Arsenical Encephalopathy
Authors: J. M. H. McMurray
Journal: BMJ (1947)

First Things First SIR,-lf there are insufficient hospital nurses Mr. Bevan's prophecy that we shall soon have the finest medical service ins the world is unlikely to be fulfilled.Thousands of hospital beds have been closed down for want of nursing staff, and the remainder are understaffed, giving rise to overwork and more resignations from the nursing service.All reforms are doomed to failure unless suitable accommodation can be provided for nurses.Cannot Mr. Bevan persuade his right hand-i.e., the Minister for Housing-that it is essential to help his left hand -i.e., the Minister of Health ?Without such help the hospital service of the country is bound to fail.In peacetime women will not agree to live in buildings designed like old-fashioned barracks, nor are they prepared to sleep two in a room.Few hospitals to-day have sufficient accommodation for nurses in or'der to start eight-hour shifts, and some have insufficient accommodation even for two shifts.The subject of accommo- dation is very urgent.The Government has realized that there is an electricity shortage, and it will take two years to build a power station; but it takes four years to train a nurse.-I am, etc.,
Photoinactivation of Herpes simplex virus continues to look promising
Authors: J. L. Melnick
Journal: JAMA (1973)

<h3>To the Editor.—</h3> This is in response to Rapp's comments on his unpublished work (225:459, 1973). First, herpes infections are often more than "superficial" and "uncomfortable." Even though in most cases superficial herpes simplex is not of serious consequence, recurrent herpes facialis may result in temporary disfiguration—important to persons whose public appearance constitutes their livelihood. In infants the disease may be fatal. Herpes genitalis is associated with a great deal of discomfort, and its recurrence often presents considerable anxiety and marital discord. Urinary retention requiring hospitalization may occur in some patients with herpes genitalis. Naturally, the judgment regarding the use of treatment rests partly on the degree of discomfort and disability produced by the disease. Second, evidence is mounting that herpes genitalis may be etiologically related to cervical cancer. If the infection can be curtailed and even eliminated when it first becomes evident, the possibility exists that this cancer might
Rhazes.
Authors: Y Andelman
Journal: Annals of the Rheumatic Diseases (1993)

Haslock patient care package.This might well put them into direct competition with physiotherapists, and align them with specialists such as chiropractors, who are already demon- strating their superiority over conventional physio- therapists in some areas of practice.2If physiotherapy is the scientifically based profession it claims to be, it may have to produce proof of its efficacy, not just of its undoubted popularity, very soon, or be supplanted by manipulators and nurses who massage.
NECROLOGY.
Authors: J. D. C. Hoit
Journal: JAMA (1897)

Dulaney L. Washburne, M.D., of Louisville, an alumnus and prosector of the University of Louisville is the subject of a warm tribute in the<i>American Practitioner and News</i>, April 3. He was born in Jefferson County, near Louisville, in 1855. He received his literary education in the public schools of that city. In 1880 he began the study of medicine under Prof. H. A. Cottell. As a student his progress was exceptionally rapid, and at the time of his graduation his rank was far above the average. He immediately found employment as assistant in the clinics of the University and teacher in the sub department. He served as assistant to Prof. John A. Ouchterlony in the medical clinic till 1886, when he was appointed prosector to the chair of anatomy and quiz master under Prof. J. M. Bodine. Here his proficiency, learning and energy found full scope and profitable exercise.
Re: Gregory T. Chesnut, Emily A. Vertosick, Nicole Benfante, et al. Role of Changes in Magnetic Resonance Imaging or Clinical Stage in Evaluation of Disease Progression for Men with Prostate Cancer on Active Surveillance. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2019.12.009
Authors: Jianhui Du, Yueguang Liu, Weigang Yan
Journal: European Urology (2020)
Book Review Specialties in Medical Practice . Volumes I and II. By Edgar Van Nuys Allen, M.D. With a foreword by Donald C. Balfour. 4°, cloth; Volume I, 441 pp., with 33 illustrations, and Volume II, 934 pp., with 21 illustrations. New York: Thomas Nelson and Sons, 1940. $25.00 (set).
Journal: New England Journal of Medicine (1940)
Dissecting Aneurysm
Authors: LARRY M. MATSUMOTO
Journal: JAMA (1974)

<h3>To the Editor.—</h3> In the case report of aortic dissection occurring in a patient with chronic hemodialysis by Chiorazzi et al (228:1146, 1974), the purported relation of dissection to hemodialysis appears tenuous, since the onset occurred seven hours after the completion of hemodialysis. Any predisposition to dissecting aneurysm in patients with hemodialysis seems more likely to reflect the greater frequency of hypertension in such patients, known to be the most common predisposing factor in spontaneous dissecting aneurysm of the aorta.<sup>1</sup> Although the authors were inclined to regard anticoagulant (heparin) therapy as an augmenting factor in dissection, the onset (of dissection) at a time when the clotting profile was normal is against this hypothesis. We are not aware of published reports in which anticoagulant therapy is believed to have precipitated dissecting aneurysm. No single instance of aortic dissection has been recognized in the population of chronic anticoagulation clinics supervised by
The Cover
Authors: M. Therese Southgate
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Regulating firearm advertisements
Authors: D. L. Orr
Journal: JAMA (1997)

<h3>To the Editor.</h3> —Dr Moul has compared a series of black men (at Walter Reed Hospital) who underwent radical prostatectomy for both palpable and nonpalpable prostate cancers with our series of men (at Johns Hopkins Hospital) with only nonpalpable prostate cancers who underwent radical prostatectomy. It is well known that men with nonpalpable prostate cancer have a greater chance of cure with surgery and thus the 2 series are not comparable. The PSA level that will both maintain the detection of curable prostate cancer and minimize the detection of insignificant cancers is unknown. Our data—based primarily on white men—suggest that this level is 4.0 ng/mL in the setting of a nonsuspicious digital rectal examination, and that below this level the risk of detecting small cancers is high. The recently published data demonstrating a 22% cancer detection rate in men (mostly white) with a PSA level between 2.6 and 4.0 ng/mL also demonstrate
A large-scale autologous blood program in a community hospital. A contribution to the community's blood supply
Authors: R. K. Haugen
Journal: JAMA (1987)

In an attempt to eliminate the hazards of homologous blood transfusions during major orthopedic surgical procedures, 1672 patients donated 6615 units of autologous blood in a ten-year period. Most of the blood components were stored frozen. The autologous units were later used in 1938 surgical procedures. Intraoperative blood salvage yielded 125105 mL of blood with an average hematocrit of 80% (0.80), which was reinfused into 934 patients. Autologous blood components accounted for 95% of the transfusion requirements. Thus, the risks of homologous transfusions were avoided in the vast majority of the procedures. Ninety-one percent of the donors were older than 50 years of age and 8.4% were between 80 and 91 years of age. The large-scale use of autologous blood has been feasible, practical, and cost efficient, has contributed to the community's blood supply, and provides the patient with the safest blood available—his own blood. (<i>JAMA</i>1987;257:1211-1214)
Ulcerative Colitis
Authors: Sumner C. Kraft
Journal: JAMA (1969)

This book, written primarily for clinicians, effectively summarizes contemporary knowledge of nonspecific ulcerative colitis. A special chapter on pathology, by Dr. Basil C. Morson, succinctly prepares the reader for subsequent discussions of clinical and radiological features, diagnosis, medical therapy, and cancer and other complications. The importance of differentiating Crohn's disease of the colon, ischemic colitis, and other specific colitides is emphasized. The final third of the text is surgically oriented, with chapters on indications for surgery, technique, ileostomy management, results, and complications. While most of the material is available in other publications, the authors stress advances in the field of inflammatory bowel disease in the past 10 to 15 years. Extensive referencing and the abundant tables and illustrations enhance the usefulness of this book. In the exposition of controversial topics, divergent views usually have been presented candidly. Many gastroenterologists might wish to modify the concluding statement that "for a substantial
Neutral Proteases of Human Polymorphonuclear Granulocytes: Putative Mediators of Pulmonary Damage
Authors: John K. Spitznagel, Malcolm C. Modrzakowski, Katherine B. Pryzwansky, Edith K. MacRae
Journal: Environmental Health Perspectives (1980)

Tissue proteolytic enzymes are currently believed to be critical to the pathogenesis of panacinar emphysema. Polymorphonuclear leukocytes (Polys) have several enzymes including elastase and cathepsin G in their azurophil granules. They have collagenase in their specific granules. We have found that this collagenase is doubly latent. It has the lysosomal type of latency that depends on the impermeability of the unit membrane that surrounds each specific granule. In addition it has a latency that is converted to activity by proteolytic enzymes. The cathepsin G of the azurophil granule is a potent activator of this latent collagenase once the collagenase is released from its membrane dependent latency. Thus latency of enzymes, the nature of the latency and accessibility of the latent enzymes to activating mechanisms must all be taken into account in any analysis of their contribution to pathogenesis of local lung disease. Equally important is that fact that polys are not a prominent cellular component of normal lung. Polys must be attracted to the lung by chemotactic peptides. These peptides must be released by the interaction of inflammatory stimuli, such as smoke particles, with complement components or they must be provided by other sources. The hypothesis that lung damage in panacinar emphysema is mediated by polys and their proteases is attractive and suggestive evidence supporting this is available. However, more evidence that takes into full account the cell biology of the proteases any poly turnover in the lung are needed to extend the hypothesis and to form a rational basis for therapeutic and prophylactic measures.
The incidence of facial injuries from dog bites
Authors: T. A. Karlson
Journal: JAMA (1984)

The incidence of hospital-treated facial injuries caused by dog bites was determined from a population-based study involving Dane County, Wisconsin, hospitals during 1978 and 1979. Annual rates were shown to be 152 per 100,000 for ages 0 to 4 years, 128 per 100,000 for ages 5 to 9 years, and 62 per 100,000 for ages 10 to 14 years. Severe facial injuries from dog bites were found almost exclusively in children younger than 10 years. If these rates apply to children in the US population, then an estimated 44,000 facial injuries, 16,000 of them severe, caused by dog bites are seen in hospitals each year. The cumulative incidence of facial injuries from dog bites for children to age 14 years is 1.6%. Most of the published advice for preventing dog bite injuries to the face suggests parental diligence in keeping children away from dogs, but options such as choosing dogs less likely to bite children may be more effective. (<i>JAMA</i>1984;251:3265-3267)
Journal summary
Journal: Annals of the Rheumatic Diseases (1991)

LEADERJuvenile chronic arthritis and antinuclear antibodies: is there a specific one?p 595 Antinuclear antibodies are usually directed against antigens contained in the cell nucleus and most children with juvenile chronic arthritis have them.They are especially significant in predicting those afflicted children who go on to develop chronic anterior uveitis and its risk of blindness.As yet, however, no specific antinuclear antibody has been identified associating particularly with juvenile chronic arthritis.
Diagnosis and Treatment of Diseases of the Thyroid Gland.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sample selection and the natural history of disease. Studies of febrile seizures
Authors: J. H. Ellenberg
Journal: JAMA (1980)

We have compared published reports on the frequency of unfavorable sequelae in a common disorder of childhood, febrile seizures, as ascertained from hospital clinics or referral units, with the frequency as reported from population-based studies. Studies on defined populations, in which the attempt was made to recognize and follow up all affected persons regardless of medical care sought for the condition, are in close agreement and indicate relatively low rates of unfavorable sequelae. Clinic-based studies of febrile seizures have reported disparate results, including high frequencies of adverse outcomes. A possible explanation is that patients in clinic-based studies may not be representative of persons with the disorder in the general population. (<i>JAMA</i>243:1337-1340, 1980)