tbuckley/cabot-search huggingface dataset:
Future Trends in Inflammation
Authors: I Johnson, E Onyewotu
Journal: Annals of the Rheumatic Diseases (1975)

Serum from 88 patients thought likely to have circulating soluble complexes were examined.The underlying clinical disorders varied from established SLE through probable SLE, rheumatoid arthritis with complications (particularly cutaneous vasculitis) to seronegative arthritides and mis- cellaneous medical conditions.This paper reports only the serological correlations.The presence of antinuclear antibodies detectable by immunofluorescence, ANA (Holborow and Johnson, 1969), was associated with electroprecipitating antibody to DNA (Johnson, Edmonds, and Holborow, 1973) and high levels of soluble complexes (Onyewotu, Holborow, and Johnson, 1974), but not with increased DNA-binding capacity and reduced C3 levels.This suggests that antibody avidity may have an important role in the procedures employed.Results of the soluble complex tests, however, were correlated with all the other serological findings except in SLE in which condition ANA positivity was independent of the level of complexes.It is therefore apparent that the ANA test alone does not provide an adequate screen for other serological abnormalities in the group of diseases studied.All possible combinations of results of the tests for DNA-binding capacity and electro- precipitating activity were obtained with serum from patients with SLE and complicated RA who had positive ANA tests and significant levels of circulating complexes.This finding accorded with the clinical overlap seen in the cases selected for study.A better understanding of the contribution of immune complexes to connective tissue disease may be achieved by the use of the five tests reported here.
Reproductive Immunology: Biomarkers of Compromised Pregnancies
Authors: W. Page Faulk, Carolyn B. Coulam, John A. McIntyre
Journal: Environmental Health Perspectives (1987)

The objective of this paper is to consider several categories of biomarkers of human pregnancy. The design of the report is to discuss useful and promising markers and techniques. Research gaps, needs, and priorities are also defined. Useful markers are mixed lymphocyte culture reactions, measures of lymphocytotoxic antibodies, histocompatibility (HLA) typing, and immunohematological evaluations. Promising markers are measures of major basic protein and early pregnancy factor, as well as determinations of trophoblast-lymphocyte cross-reactive (TLX) antigens. Promising techniques are fluorescence-activated cell-sorter analysis of maternal blood for fetal and extraembryonic tissues and immunotherapy with TLX and other antigens to prevent spontaneous abortion. It is concluded that immunology has much to offer the development of biomarkers of human pregnancy.
Omalizumab for the Treatment of Chronic Idiopathic or Spontaneous Urticaria
Authors: Tian Bai
Journal: New England Journal of Medicine (2013)

samples collected between January 2012 and November 2012 from poultry workers in Shanghai, Zhejiang, Jiangsu, and Anhui provinces, all located in eastern China.The stored serum samples were from a routine national surveillance program on subclinical infection of avian influenza of poultry workers, approved by the Ministry of Health in China since 2008.This is part of national pandemic-preparedness plan, so a requirement for informed consent was waived according to the regulatory policy in China.A total of 1544 single serum samples were collected from key occupational groups, including workers from live-poultry markets, farms, poultry yards, slaughterhouses, and wild-bird habitats.The ratio of female to male participants in the study ranged from 0.7 to 1.2 in the four provinces, and most participants were 25 to 59 years of age (65.5% to 78.1% in the four provinces) (see the Supplementary Appendix, available with the full text of this letter at NEJM.org).A hemagglutination-inhibition (HAI) assay using turkey red cells was employed for preliminary antibody screening.A microneutralization (MN) assay was used for confirmation if an HAI titer of 20 or more was obtained. 5An MN titer of 20 or more was defined as seropositive.Influenza A/Anhui/1/ 2013 (H7N9) virus was used for the HAI and MN assays.HAI titers of 20 or more were detected in 7 of 1544 serum samples (5 with an HAI titer of 20 and 2 with an HAI titer of 40), but none of the 1544 samples were positive by the MN assay (MN titer <10).This retrospective serologic study does not find any evidence for human infection with the novel avian-origin influenza A (H7N9) virus in poultry workers before November
Early fingertip changes in scleroderma
Authors: H. Y. Yune
Journal: JAMA (1971)

Roentgenographs of the hands of 52 patients with scleroderma were compared with those of 43 patients with other collagen diseases and 22 patients with primary Raynaud's disease. Abnormal roentgenographic findings were noted in 33 (63%) of patients with scleroderma as compared to 5% (2) of patients with other collagen disease and 41% (9) of patients with primary Raynaud's disease. In scleroderma roentgenographic changes are commonly seen early in the course of the disease. Soft tissue atrophy of the fingertips is usually associated with neurovascular manifestations (Raynaud's phenomenon). Calcifications of the pulp of the fingertip and bone erosion are commonly seen in scleroderma and are not necessarily associated with the presence or absence of Raynaud's phenomenon.
Incorrect Affiliation in: Cardiovascular Response to a Modern Roller Coaster Ride
Authors: Dae Kim, Inder Singh, Benjamin Ansell
Journal: JAMA (2007)

Saturated fatty acids increase levels of low-density lipoprotein cholesterol (LDL-C) and HDL-C, 2 whereas transfatty acids increase LDL-C level but decrease HDL-C level. 2,3 This distinction is important, because trans-fatty acids are more strongly associated with the risk of cardiovascular disease than saturated fatty acids due to their undesirable effects on LDL-C and HDL-C levels, endothelial cell function, adipocytes, and inflammatory response. 3,4
Receipt of Outpatient Cardiac Rehabilitation Among Heart Attack Survivors—United States, 2005
Journal: JAMA (2008)

Each year, approximately 865,000 persons in the United States have a myocardial infarction (i.e., heart attack). In 2007, direct and indirect costs of heart disease were estimated at approximately $277.1 billion. Cardiac rehabilitation, an essential component of recovery care after a heart attack, focuses on cardiovascular risk reduction, promoting healthy behaviors, reducing death and disability, and promoting an active lifestyle for heart attack survivors. Current guidelines from the American Heart Association (AHA) and the American Association of Cardiovascular and Pulmonary Rehabilitation emphasize the importance of cardiac rehabilitation, which reduces morbidity and mortality, improves clinical outcomes, enhances psychological recovery, and decreases the risk for secondary cardiac events. To estimate the prevalence of receipt of outpatient cardiac rehabilitation among heart attack survivors in 21 states and the District of Columbia (DC), data from the 2005 Behavioral Risk Factor Surveillance System (BRFSS) were assessed. The results of that assessment indicated that 34.7% of BRFSS respondents who had experienced a heart attack participated in outpatient cardiac rehabilitation. Outpatient cardiac rehabilitation for eligible patients after a heart attack is an essential component of care that should be incorporated into treatment plans. Increasing the number of persons who participate in cardiac rehabilitation services also can reduce health-care costs for recurrent events and reduce the burden on families and caregivers of patients with serious sequelae.
Stress echocardiography for risk stratification of patients with chest pain and no obstructive coronary lesion Alessandro Desideri, Riccardo Bigi, Lauro Cortigiani, Jeroen J. Bax, Carlo Sponzilli, Diego Castini, Cesare Fiorentini. Cardiovascular Research Fondation, Castelfranco Veneto, Italy, ?S. Paolo? Academic Hospital, Milan, Italy
Journal: Journal of the American College of Cardiology (2001)
Do emergency tests help in the management of acute medical admissions?
Journal: BMJ (1984)

dstress Metabolic ackiosis Hyperpyrexia Hyperglycoeamia R if nmpicin Bright red skin pigmentation Red discoloumtion d plasma and urine Liver damage Ethambutol Nausea Abdominal pain Fever Mental confusion Visual hallucinations Optic neuropathyCompound cough mixtures and cold remedies may contain a variety of opioids, antihistamines, and sympathomimetic and mucolytic agents.The management of opioid and antihistamine overdose is covered elsewhere.The various sympathomimetic agents cause acute behavioural disturbances including visual and auditory hallucinations as well as features of cc and i overactivity.These may require specific treatment in the form of sedation or sympathomimetic blocking agents, or both.Chronic use of these drugs may cause behavioural disorders and hallucinations which remit on withdrawal of the drug.Anticholinergic drugs-Agents such as ipratropium bromide are being used increasingly in the treatment of asthma.When administered by inhalation these have a wide safety margin, but accidental or deliberate self-poisoning with nebuliser fluid may cause pronounced anticholinergic poisoning.There have been a few reports of paradoxical bronchoconstriction after both aerosol or high dose nebulised anticholinergic compounds.The reaction to the aerosol is thought to be an allergic response, but the reaction to the nebulised solution may be due to inhalation of a non-isotonic solution.Corticosteroids are occasionally taken in acute overdose but toxic effects are unlikely.Sodium cromoglycate is of low toxicity and overdose needs no specific
Immunogenicity of biliary epithelium: Investigation of antigen presentation to CD4+ T cells
Authors: M Leon
Journal: Hepatology (1996)

The intrahepatic biliary epithelium is susceptible to extensive T-cell- mediated damage during primary biliary cirrhosis, primary sclerosing cholangitis, and hepatic allograft rejection. During these processes, human intrahepatic biliary epithelial cells (HIBEC) become activated and express high levels of the lymphocyte adhesion molecules, intercellular adhesion molecule-1 (ICAM-1) and lymphocyte-associated antigen (LFA)-3, and of class II MHC antigens. It follows that activated HIBEC may also play a direct role in the activation of antigen-specific CD4+ T lymphocytes. The capacity of class II MHC antigen-expressing HIBEC to present antigen and induce specific proliferation of CD4+ T cells was examined in this study. Lines of purified HIBEC were activated by culture with the proinflammatory cytokines interferon γ (IFN-γ) and tumor necrosis factor a and were mixed in coculture with allogeneic CD4+ T cells. The result of interaction between these cells was assessed by measurement of lymphoproliferation and IL-2 production. Class II MHC antigen-expressing HIBEC failed to induce either lymphoproliferation or IL-2 production. However, both of these parameters of T-cell activation were positive in cocultures when a costimulation signal was delivered to T cells by adding bivalent anti-CD28 antibodies. The antigen-specific activation of these T cells was further enhanced by the addition of a cross-linking secondary antibody that caused CD28 receptor aggregation. The failure of cytokine-stimulated HIBEC to induce T-cell activation is consistent with the observation that HIBEC do not express the costimulatory CD28 ligands B7-1 or B7-2 at either mRNA or protein levels. It may be concluded that HIBEC are unlikely to play a direct role in activation of antigen-specific CD4+ T lymphocytes within the inflamed liver.
Advances in Cancer Research. Volume I
Journal: JAMA (1953)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Use of Statins and Risk of Fractures—Correction
Authors: Pekka Kannus, Mika Palvanen, Seppo Niemi
Journal: JAMA (2001)

were 164, 143, and 281, vs 436, 546, and 706 in the period 1995 through 1999.The hip fracture data mirrored the head injury data.In women, the age-adjusted incidence of hip fracture (per 100000 persons aged 80 years or older) was 1445 in 1970, compared with 2406 in 1999; in men, these incidences were 682 and 1458, respectively.Comment.This study shows that the rates of both raw and age-adjusted fall-induced severe head injuries of persons aged 80 years or older increased dramatically during the study period.These data corroborate previous observations on the development of fall-related injuries in elderly people 1-3,6 but cannot reveal the exact reasons for the increase in the ageadjusted or age-specific incidence of injury.It has been suggested that an increase in the average risk of falling may partly ex-plain the phenomenon, or that elderly people now have more serious consequences of falling than their predecessors. 1-3In other words, on average, elderly persons may now be less healthy and functionally less capable than in the past.The number of fall-induced severe head injuries among Finns aged 80 years or older shows a rise with a rate that cannot be explained merely by demographic changes, and a better understanding of this phenomenon is needed.
<i>Circulation</i> Editors' Picks
Journal: Circulation (2011)

The following articles are being highlighted as part of Circulation's Topic Review series. This series will summarize the most important manuscripts, as selected by the editors, published in Circulation and the Circulation subspecialty journals. The studies included in this article represent the most read manuscripts published on the topic of cardiovascular surgery and transplantation in 2009 and 2010.
Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy
Authors: Valérie Risson, Laetitia Mazelin, Mila Roceri, Hervé Sanchez, Vincent Moncollin, Claudine Corneloup, Hélène Richard-Bulteau, Alban Vignaud, Dominique Baas, Aurélia Defour, Damien Freyssenet, Jean-François Tanti, Yannick Le-Marchand-Brustel, Bernard Ferrier, Agnés Conjard-Duplany, Klaas Romanino, Stéphanie Bauché, Daniel Hantaï, Matthias Mueller, Sara C. Kozma, George Thomas, Markus A. Rüegg, Arnaud Ferry, Mario Pende, Xavier Bigard, Nathalie Koulmann, Laurent Schaeffer, Yann-Gaël Gangloff
Journal: The Journal of Experimental Medicine (2009)
Three Retinal Detachment Operations on an Eye Containing a Choroidal Melanoma
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SLOW DEMONSTRATION OF PARASITIC ETIOLOGY.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Vital Questions.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Liver Function Test Developed
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 2879: Comparison of Bilateral Internal Thoracic Artery Revascularization Using Pedicled or Y Graft Configurations: A Prospective Randomized Clinical, Functional and Angiographic Mid-term Evaluation.
Authors: David Glineur, Claude Hanet, Philippe Noirhomme, Alain Poncelet, Jean Christophe Funken, Parla Astarci, Jean Rubay, Valerie Lacroix, Robert Verhelst, Gebrine El Khoury
Journal: Circulation (2007)

For the left coronary system, bilateral internal thoracic arteries (BITA) have demonstrated their superiority over all others types of grafts in terms of patency and survival benefit. Several configurations of BITA have been proposed to achieve left-sided myocardial revascularization. Because the ideal BITA assembling has not yet been found, we have prospectively randomized two types of BITA configurations to evaluate at 6 months and 3 years the clinical, functional and angiographic outcome.From 03/2003 to 08/2006, 1297 consecutive patients underwent isolated bypass surgery in our institution. Of this group, 481 patients met the entrance criteria for randomization and 304 (64%) patients were randomized. BITA grafting was performed with a pedicled configuration in 147 patients and with a Y configuration in 152. Patients were interviewed by telephone every 3 months and had a systematic stress test twice a year performed under supervision of their referring cardiologists. Systematic angiographic follow-up was performed 6 months after surgery. The primary and secondary end point was respectively the major adverse cerebro-cardiovascular events (MACCE) and the proportion of ITA grafts that were completely occluded at follow-up angiography. More arterial anastomoses were performed in patients randomized in the Y than in the pedicled configuration (3.2 versus 2.4; p&lt; 0.001). There were no significant differences between the 2 groups in terms of hospital mortality or morbidity. Clinical follow-up is 100 % complete with a mean of 16 ± 11 months. At follow-up there is no significant difference in any MACCE rate between the 2 groups. Angiographic follow-up is 90% complete with a mean of 6.5 months. 432 out of 446 anastomosis in the BITA Y group and 278 out of 286 in the BITA pedicled group were controled patent (p=0.96).Excellent patency rates were achieved in both groups with no significant difference in terms of MACCE or patency. Whether the higher number of ITA distal anastomoses in the Y configuration group will translate in better long-term results remains to be established.
Books Received
Authors: Richard Balon, Maurizio Fava, Mario Maj, Giovanni A. Fava, Elena Tomba, Silvana Grandi, George I. Papakostas, Roy H. Perlis, Cheryl Seifert, Maurizio Fava, Francesc Colom, Eduard Vieta, Marc B.J. Blom, Kosse Jonker, Elise Dusseldorp, Philip Spinhoven, Erik Hoencamp, Judith Haffmans, Richard van Dyck, Giuseppe Maina, Gianluca Rosso, Chiara Crespi, Filippo Bogetto, Stijn Vanheule, Mattias Desmet, Paul Verhaeghe, Stefan Bogaerts, Kirsi Honkalampi, Jukka Hintikka, Heli Koivumaa-Honkanen, Risto Antikainen, Kaisa Haatainen, Heimo Viinamäki, Brandon A. Gaudiano, Ivan W. Miller, James D. Herbert
Journal: Psychotherapy and Psychosomatics (2007)