THE PRESENT STATUS OF FOLIC ACID IN THE THERAPY OF MACROCYTIC ANEMIA
Authors: M. S. S.
Journal: Annals of Internal Medicine (1948)

Editorial1 February 1948THE PRESENT STATUS OF FOLIC ACID IN THE THERAPY OF MACROCYTIC ANEMIAM. S. S.M. S. S.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-28-2-461 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe control of Addisonian pernicious anemia by the use of liver undoubtedly represents one of the most notable contributions of modern medicine to the welfare of mankind. Castle's hypothesis,1conceived as a result of a series of ingenious clinical investigations, supplied the theoretical basis for an understanding of the mode of development of this and related macrocytic anemias. The effectiveness of extracts of liver in a variety of clinical entities has usually been explained by reference to this "unitarian" hypothesis which was based upon the interaction of an "extrinsic" dietary factor with an "intrinsic" gastric factor leading to the...1 CASTLETOWNSENDHEATHSTRAUSS WBWCCWMC: Observations on the etiologic relationship of achylia gastrica to pernicious anemia, I-IV, Am. Jr. Med. Sci., 1929, clxxviii, 748, 764; 1930, clxxx, 305; 1931, clxxxii, 741. CrossrefGoogle Scholar2 WILLSEVANS LBD: Tropical macrocytic anemia: its relation to pernicious anemia, Lancet, 1938, ii, 416. CrossrefGoogle Scholar3 WATSONCASTLE JWB: Nutritional macrocytic anemia especially in pregnancy. Response to a substance other than that effective in pernicious anemia, Am. Jr. Med. Sci., 1946, ccxi, 513. CrossrefGoogle Scholar4 CASTLEROSSDAVIDSONBURCHENALFOXHAM WBJBCSJHHJTH: Extrinsic factor in pernicious anemia: ineffectiveness of purified casein and of identified components of the vitamin B complex, Science, 1944, c, 81. CrossrefGoogle Scholar5 CLARK GW: Vitamin content of liver extracts for parenteral use, Am. Jr. Med. Sci., 1945, ccix, 520. CrossrefGoogle Scholar6 PFIFFNERBINKLEYBLOOMBROWNBIRDEMMETTHOGANO'DELL JJSBESRAODADAGBL: Isolation of the anti-anemia factor (vitamin Bc) in crystalline form from liver, Science, 1943, xcvii, 404. CrossrefGoogle Scholar7 ANGLERBOOTHEHUTCHINGSNOWATSEMBSTOKSTADSUBBAROWWALLERCOSULICHFAHRENBACHHULTQUISTKUHNORTHEYSEEGERSICKELSSMITH RBJHBLJHJELYCWDBMJMEEEHDRJPJM: Synthesis of a compound identical with the L. casei factor isolated from liver, Science, 1945, cii, 227. CrossrefGoogle Scholar8 DAYLANGSTONDARBY PLWCWJ: Failure of nicotinic acid to prevent nutritional cytopenia in the monkey, Proc. Soc. Exper. Biol. and Med., 1938, xxxviii, 360. Google Scholar9 HOGANPARROTT AGEM: Anemia in chicks caused by a vitamin deficiency, Jr. Biol. Chem., 1940, cxxxii, 507. CrossrefGoogle Scholar10 SNELLPETERSON EEWH: Growth factors for bacteria. X. Additional factors required by certain lactic acid bacteria, Jr. Bact., 1940, xxxix, 273. CrossrefGoogle Scholar11 MICHELLSNELLWILLIAMS HKEERJ: The concentration of "folic acid," Jr. Am. Chem. Soc., 1941, lxiii, 2284. CrossrefGoogle Scholar12 HUTCHINGSBOHONOSPETERSON BLNWH: Growth factors for bacteria. Purification and properties of an eluate factor required by certain lactic acid bacteria, Jr. Biol. Chem., 1941, cxli, 521. CrossrefGoogle Scholar13 OLSONBURRISELVEHJEM OERHCA: Preliminary report of folic acid content of certain foods, Jr. Am. Diet. Assoc., 1947, xxiii, 200. Google Scholar14 JUKES TH: Pteroylglutamic acid in nutrition, Jr. Am. Diet. Assoc., 1947, xxiii, 193. Google Scholar15 SWANSEIDBIRDBROWNBETHELL MEODRAFH: Metabolic function of pteroylglutamic acid and its hexaglutamyl conjugate. II. Urinary excretion studies on normal persons. Effect of a conjugase inhibitor, Jr. Lab. and Clin. Med., 1947, xxxii, 23. Google Scholar16 BIRDROBBINSVAN DEN BELTPFIFFNER ODMJMJJ: Observations on vitamin Bc conjugase from hog kidney, Jr. Biol. Chem., 1946, clxiii, 649. CrossrefGoogle Scholar17 SPIESFROMMEYERVILTERENGLISH TDWBCFA: Anti-anemic properties of thymine, Blood, 1946, i, 185. CrossrefGoogle Scholar18 DAFT FS: Folic acid. Physiological aspects, Ann. N. Y. Acad. Sci., 1946, xlviii, 299. CrossrefGoogle Scholar19 BETHELLMEYERSANDREWSSWANSEIDBIRDBROWN FHMCGAMEODRA: Metabolic function of pteroylglutamic acid and its hexaglutamyl conjugate. I. Hematologic and urinary excretion studies on patients with macrocytic anemia, Jr. Lab. and Clin. Med., 1947, xxxii, 3. Google Scholar20 SPIESSTONE TDRD: Liver extract, folic acid, and thymine in pernicious anemia and subacute combined degeneration, Lancet, 1947, i, 174. CrossrefGoogle Scholar21 HEINLEWELCH RWAD: Folic acid in pernicious anemia: failure to prevent neurologic relapse, Jr. Am. Med. Assoc., 1947, cxxxiii, 739. CrossrefGoogle Scholar22 WAGLEY PF: Neurologic disturbances with folic acid therapy, New Eng. Jr. Med., 1948, ccxxxviii, 11. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEin Beitrag Zur Frage Der Folins�uretherapie 1 February 1948Volume 28, Issue 2Page: 461-465KeywordsAnemiaFolic acidLiverPernicious anemia ePublished: 1 December 2008 Issue Published: 1 February 1948 PDF downloadLoading ...