tbuckley/cabot-search huggingface dataset:
Expanded phase I/II study of PTK787/ZK 222584 (PTK/ZK), a novel, oral angiogenesis inhibitor, in combination with FOLFOX-4 as first-line treatment for patients with metastatic colorectal cancer
Authors: W. P. Steward, A. Thomas, B. Morgan, B. Wiedenmann, C. Bartel, U. Vanhoefer, T. Trarbach, U. Junker, D. Laurent, D. Lebwohl
Journal: Journal of Clinical Oncology (2004)

3556 Background: Increased angiogenesis correlates with poor prognosis in patients with metastatic colorectal cancer (CRC). PTK/ZK is a novel, oral angiogenesis inhibitor that potently inhibits all known VEGF receptor tyrosine kinases, which are important mediators of the formation of new blood vessels that contribute to tumor growth and metastasis. Methods: This phase I/II study assessed the safety and preliminary response profile of oral PTK/ZK in combination with chemotherapy. Previously untreated patients (N = 35) with advanced CRC were treated with escalating doses of PTK/ZK plus oxaliplatin/5-fluorouracil (5-FU)/leucovorin (FOLFOX4). PTK/ZK was administered once daily at doses of 500 mg (n = 4), 1,000 mg (n = 3), 1,250 mg (n = 23), 1,500 mg (n = 3), and 2,000 mg (n = 2). FOLFOX-4 was administered q 2 weeks, and consisted of oxaliplatin (85 mg/m2) infusion on day 1, leucovorin (200 mg/m2 via 2-hour infusion) on days 1 and 2, and 5-FU (400 mg/m2 bolus followed by 600 mg/m2 over 22 hours) on days 1 and 2. Results: The pharmacokinetics and toxicity profiles of both PTK/ZK and FOLFOX4 were unaffected by coadministration. PTK/ZK was well tolerated at doses ≤ 1,250 mg/day; no DLTs occurred at 1,250 mg/day in the first 6 patients evaluated for MTD. Adverse events at 1,250 mg/day included ataxia (grade [G] 3), neutropenia (G4), thrombocytopenia (G3), and 2 episodes of dizziness (G3). CNS adverse events (G3/4) were dose-limiting in 2 patients at 2,000 mg/day, and expressive dysphasia (G3) and intermittent dizziness (G3) were dose-limiting at 1,500 mg/day. Best response data by SWOG criteria for 28 evaluable patients to date showed 1 (4%) CR, 14 (50%) PR, and 9 (32%) patients had SD. For 34 evaluable patients, median PFS is 11 months (95% CI = 6.8, 12.0 months). Estimated median overall survival for 35 patients is 16.6 months (95% CI = 12.9, 21.0 months). Conclusions: The early efficacy and safety of PTK/ZK+FOLFOX4 for metastatic CRC has been encouraging, and phase III randomized controlled trials of PTK/ZK+FOLFOX4 in metastatic CRC (CONFIRM-1 & -2) are ongoing. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Novartis Pharmaceuticals Corp.; Schering AG Novartis Pharmaceuticals Corp. Novartis Pharmaceuticals Corp.
Should patients with early mycosis fungoides, a skin cancer of immune cells, undergo imaging to detect lymph node involvement?
Journal: British Journal of Dermatology (2021)

Mycosis fungoides (MF) is a form of lymphoma, a cancer of immune cells called lymphocytes. In the early stages of MF only the skin is involved in the form of patches or plaques. In the later stages the skin is characterized by the appearance of nodules or generalized skin involvement, and the lymphoma may spread beyond the skin to involve primarily lymph nodes (glands) that become enlarged. In order to accurately assess the size and the structure of the lymph nodes imaging is needed. Because of the rarity of involvement of lymph nodes in patients with MF who have patches or plaques, current guidelines differ about the need to perform imaging at this early stage. In daily practice, there are physicians who recommend imaging in patch‐plaque MF only in the presence of enlarged lymph nodes on clinical examination. Policies vary between countries and between centres.
Air transportation after eye surgery
Authors: D. L. Roper
Journal: JAMA (1982)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Childhood Cancer in Relation to a Modified Residential Wire Code
Authors: David A. Savitz, William T. Kaune
Journal: Environmental Health Perspectives (1993)

Several studies have found associations between wire configuration codes, a proxy for historical residential magnetic field exposure, and childhood cancer. The Wertheimer-Leeper coding method was modified by eliminating the distinction between thick and thin primaries, distinguishing only between open and spun secondaries, and reducing the number of categories from five to three. The association between the modified code and measured magnetic fields was similar to the association with the original wire code. The modified code was used to reanalyze data from a case-control study of childhood cancer in the Denver metropolitan area. In the original study, cases were diagnosed from 1976 to 1983 among children under age 15 and compared to controls selected through random digit dialing. Wire codes for the residence at diagnosis yielded imprecise elevations of two and above for very high current configuration homes or modest 1.5-fold elevations for a dichotomous wire code. In contrast, the modified Wertheimer-Leeper code generated risk estimates that were both precise and markedly elevated for the high wire code (HWC) compared to low wire code (LWC) classifications, with medium wire code (MWC) showing little or no increase in risk. High wire code yielded odds ratios of 1.9 for total cancers (95% CI: 1.1-3.2), 2.9 for leukemias (95% CI: 1.5-5.5), and 2.5 for brain cancer (95% CI: 1.1-5.5) that were not confounded by measured potential risk factors for childhood cancer. These risk estimates are larger than the dichotomized results and more precise than those from the original five-level wire code, though limitations in the original study remain, particularly potential control selection bias.(ABSTRACT TRUNCATED AT 250 WORDS)
THE AGLOMERULAR KIDNEY
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Journal of Urology, Baltimore
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BOOK REVIEWS
Authors: B. J. BROOKS
Journal: JNCI Journal of the National Cancer Institute (1989)

Journal Article BOOK REVIEWS Get access Manual of Oncologic Therapeutics, 1989/1990 Robert E. Wittes, ed. Philadelphia: J. B. Lippincott Company, 1989, 685 pp. Paper, $24.50. BURKE JOSEPH BROOKS, JR. BURKE JOSEPH BROOKS, JR. Ochsner Clinic of Baton Rouge16777 Medical Center Dr. Baton Rouge, LA 70816 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 81, Issue 10, 22 May 1989, Pages 810–811, https://doi.org/10.1093/jnci/81.10.810-a Published: 22 May 1989
Guidelines for Clinical Intracardiac Electrophysiologic Studies. A report of the American College of Cardiology/American Heart Association Task Force on Assessment of Diagnostic and Therapeutic Cardiovascular Procedures (Subcommittee to Assess Clinical Intracardiac Electrophysiologic Studies).
Journal: Circulation (1989)

It is becoming more apparent each day that despite a strong national commitment to excellence in health care, the resources and personnel are finite.Therefore, it is appropriate that the medical profession examine the impact of developing tech- nology on the practice and cost of medical care.Such analysis, carefully conducted, could potentially impact on the cost of medical care without diminishing the effectiveness of that care.
hypervolemic hemodilution in acute stroke
Authors: J. M. Hallenbeck
Journal: JAMA (1982)

The article by Wood and Fleischer (p 2999) reports an excellent therapeutic response to hypervolemic hemodilution in nine consecutive unselected patients with acute stroke, the third leading cause of death in the United States. Eight of nine patients showed objective improvement of their acute neurological deficits, and one patient with a depressed level of consciousness, a grave prognosticator,<sup>1</sup>died. Published accounts of the natural history of acute hemispheric cerebral ischemia<sup>2</sup>would lead to the expectation that of nine consecutive patients, three or four would improve, three to five would remain unchanged or deteriorate, and one to three would die. The observed results of Wood and Fleischer contrast favorably with these expectations and suggest a potential therapeutic value for hypervolemic hemodilution in acute stroke. The results also provide an encouraging follow-up to experimental work in animals done by one of the authors. This prospective evaluation, however, is not a
In utero supplementation with methyl donors enhances allergic airway disease in mice
Authors: John W. Hollingsworth, Shuichiro Maruoka, Kathy Boon, Stavros Garantziotis, Zhuowei Li, John Tomfohr, Nathaniel Bailey, Erin N. Potts, Gregory Whitehead, David M. Brass, David A. Schwartz
Journal: Journal of Clinical Investigation (2008)

Asthma is a complex heritable disease that is increasing in prevalence and severity, particularly in developed countries such as the United States, where 11% of the population is affected. The contribution of environmental and genetic factors to this growing epidemic is currently not well understood. We developed the hypothesis, based on previous literature, that changes in DNA methylation resulting in aberrant gene transcription may enhance the risk of developing allergic airway disease. Our findings indicate that in mice, a maternal diet supplemented with methyl donors enhanced the severity of allergic airway disease that was inherited transgenerationally. Using a genomic approach, we discovered 82 gene-associated loci that were differentially methylated after in utero supplementation with a methyl-rich diet. These methylation changes were associated with decreased transcriptional activity and increased disease severity. Runt-related transcription factor 3 (Runx3), a gene known to negatively regulate allergic airway disease, was found to be excessively methylated, and Runx3 mRNA and protein levels were suppressed in progeny exposed in utero to a high-methylation diet. Moreover, treatment with a demethylating agent increased Runx3 gene transcription, further supporting our claim that a methyl-rich diet can affect methylation status and consequent transcriptional regulation. Our findings indicate that dietary factors can modify the heritable risk of allergic airway disease through epigenetic mechanisms during a vulnerable period of fetal development in mice.
Oration.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Highlights
Journal: JAMA Pediatrics (2014)

Crash and Near-Crash Rates Among Teenaged Drivers 517Despite improvements in vehicles and driver training programs, some teens appear to still be at high risk for a motor vehicle crash.In this longitudinal study of newly licensed teenage drivers, Ouimet and colleagues studied the driving behavior and cortisol responses to stress in 40 teens driving instrumented vehicles that could detect crashes and near-crash maneuvers.Teens with higher baseline cortisol response had lower crash and near-crash rates during the follow-up period, and their driving improved at a more rapid rate.The implications of this study for clinicians and for future research are discussed by Durbin and colleagues in their accompanying editorial.
Additional data on the shooting of President Kennedy
Authors: J. K. Lattimer
Journal: JAMA (1993)

The journalhas performed a great service in persuading Humes, Boswell, and Finck to answer extended queries about the details of the autopsy of President Kennedy.<sup>1,2</sup>They replied directly to many of the questions raised by the critics of the Warren Commission report, an excellent move toward "full disclosure." However, we must remember that Humes, Boswell, and Finck wrote their autopsy report without seeing the color photographs or studying in detail the roentgenograms of the body that were taken at the autopsy. The photographs had been confiscated by the Attorney General (the President's brother) without being developed, and they were then turned over to the National Archives (from which they have never been released). The basis for this confiscation was the family's desire that the photographs of the President's exploded head not appear in every bookstore window, as they would have had See also pp 1507, 1540, and 1552.
FRANCE
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Highlights
Journal: JAMA Neurology (2019)

Associations Between Migraine and Type 2 Diabetes in Women 257Although migraine is more common in women of reproductive age and has been associated with increased risk of cardiovascular events and hypertension, data are unclear regarding an association between migraine and type 2 diabetes in women.Using data from a prospective cohort of 74 247 women from the large French E3N study, Fagherazzi and coauthors observed a lower risk of type 2 diabetes in women with active migraine over 10year follow-up.A linear decrease of migraine prevalence long before and a plateau long after type 2 diabetes diagnosis suggest a potential role of both hyperglycemia and hyperinsulinism on migraine occurrence.Editorial perspective is provided by Gelfand and Loder.
Silver stools
Authors: Y. Y. Ong
Journal: JAMA (1979)

A STOOL specimen was sent to the laboratory with a request for a heavymetal screen. On examination, a metallic silver sheen was noted (Figure). The test for occult blood was positive, and the test for bile was negative. <h3>Report of a Case</h3> A 78-year-old woman was admitted to the hospital because of jaundice, weight loss, and dehydration. Physical examination showed she was cachectic and deeply jaundiced with icteric scleras. No abdominal masses were palpated. Rectal examination showed 4+ guaiac-positive stools. Pertinent laboratory findings included the following: hemoglobin, 12 g/dL; hematocrit, 34.7%; total bilirubin, 10 mg/dL; direct bilirubin, 7.3 mg/dL; SGOT, 67 IU/L; and alkaline phosphatase, 668 IU/L. Abdominal ultrasonography showed massive dilation of the common duct, an obstruction presumably caused by a neoplasm in the head of the pancreas. Percutaneous transhepatic cholangiography showed complete obstruction of the distal common bile duct, characterized by tapered, slightly asymmetric narrowing consistent with compression
银屑病患者的述情障碍逆转
Authors: F. Sampogna, L. Puig, P. Spuls, G. Girolomoni, M.A. Radtke, B. Kirby, M. Brunori, P. Bergmans, P. Smirnov, J. Rundle, A. Castiglia, F. Lavie, C. Paul
Journal: British Journal of Dermatology (2019)

述情障碍是指不能识别和表达情感。这种疾病在患有关节炎、炎症性肠病等慢性炎症性疾病的患者中更为常见。该国际工作组此前在“对近期确诊的银屑病患者进行的流行病学研究” (Epidemiological Study In Patients With Recently DiagnosEd PSOriasis, EPIDEPSO) 中得出的结果表明,述情障碍也会影响成年重度银屑病患者;受影响者更有可能出现焦虑和抑郁,酗酒和失业的风险也较高。一个重要的问题是,述情障碍是固定不变的人格特质,还是随着银屑病好转能够得到改善的疾病状态:也许有些银屑病患者会封闭对情感的识别,就像感觉受到污蔑时启动的防御机制。为了回答这个问题,本文作者对最初参加 EPIDEPSO 研究的患者中的 467 名患者进行了一年随访,随访始于这些患者开始接受全身性药物治疗(即药物作用于全身,而不是仅涂抹于皮肤)或紫外线治疗之时。述情障碍的发病率从 26.7% 显著降低至 18.8%,这种改善在年龄小于 40 岁、曾出现过焦虑和抑郁、近期在显眼部位发生过银屑病或者对治疗反应良好的患者中最为明显。随访期间银屑病完全或几乎完全消除的患者获得了最大程度的述情障碍改善。一年后,酗酒发生率几乎降至 1/3。虽然述情障碍的改善与银屑病的缓解相关,但作者承认,他们使用的评估工具不够完美,无法对此建立因果关系。尽管如此,作者仍得出以下结论:存在述情障碍和重度银屑病的患者需要接受心理辅导和积极的银屑病治疗。
Film Reviews
Journal: JAMA (1975)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Considerations in the Design of an Environmental Specimen Bank: Experiences of the National Biomonitoring Specimen Bank Program
Authors: Stephen A. Wise, Barbara J. Koster
Journal: Environmental Health Perspectives (1995)

Since 1979 the National Institute of Standards and Technology (NIST) has been involved in environmental specimen banking activities as part of the National Biomonitoring Specimen Bank (NBSB).These activities have focused on the development of procedures for the collection, processing, analysis, and long-term storage of a variety of environmental specimens including: human liver, mussels and oysters, fish tissue (liver and muscle), marine mammal tissues (blubber, liver, and kidney), and marine sediments.The experiences of the NBSB can provide valuable information to assist in the design of new specimen bank efforts.