tbuckley/cabot-search huggingface dataset:
Quinacrine ochronosis and rheumatoid arthritis
Authors: M. J. Egorin
Journal: JAMA (1976)

BLUE-BLACK mucocutaneous hyperpigmentation has been reported as a consequence of therapy with quinacrine hydrochloride and related antimalarial drugs.<sup>1-3</sup>Similar discoloration occurs with the metabolic disorder alcaptonuria and is associated with pigment deposition in articular cartilage and premature degenerative joint disease. Ludwig et al<sup>4</sup>reported a single case of quinacrine ochronosis and postulated an association between the pigmentation of the skin and premature lumbar degenerative arthropathy. Joint tissue has not, however, been described in any case of antimalarial hyperpigmentation. This report describes a patient treated for rheumatoid arthritis with quinacrine in whom the classic skin changes of antimalarial ochronosis developed. In the course of her management, joint tissue became available for histologic study; the findings of the examination of this tissue form the basis for this report. <h3>Report of a Case</h3> A 58-year-old woman had a 25-year history of chronic deforming rheumatoid arthritis. Her course has been one of
Developing Standards for Environmental Toxicants: The Need to Consider Abiotic Environmental Factors and Microbe-Mediated Ecologic Processes
Authors: H. Babich, G. Stotzky
Journal: Environmental Health Perspectives (1983)

This article suggests and discusses two novel aspects for the formulation of standards for environ- mental toxicants.First, uniform national standards for each pollutant will be underprotective for some ecosystems and overprotective for others, inasmuch as the toxicity of a pollutant to the indigenous biota is dependent on the physicochemical properties of the recipient environment.As the number of chemicals that need regulation is immense and as microbes appear to respond similarly to pollutant-abiotic factor interactions as do plants and animals, it is suggested that microbial assays be used initially to identify those abiotic factors that most influence the toxicity of specific pollutants.Thereafter, additional studies using plants and animals can focus on these pollutant-abiotic factor interactions, and more meaningful standards can then be formulated more rapidly and inexpensively.Second, it is suggested that the response to pollutants of microbe-mediated ecologic processes be used to quantitate the sensitivity of different ecosystems to various toxicants.Such a quantification, expressed in terms of an "ecological dose 50%" (EcD50), could be easily incorporated into the methodologies currently used to set water quality criteria and would also be applicable to setting criteria for terrestrial ecosystems.
Therapeutics.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Secrecy around PFI projects should be lifted
Authors: R. Dobson
Journal: BMJ (2001)

Poor antenatal care implicated in half of stillbirths 68, 71Poor antenatal care might have contributed to the outcome in up to half of stillbirths recorded in England, Wales, and Northern Ireland during 1996 and 1997, says a report published last week by the Confidential Enquiry into Stillbirths and Deaths in Infancy.The eighth annual reportpublished as part of the enquiry's ongoing remit to identify areas of suboptimal care contributing to the deaths of babies between 20 weeks' gestation and 1 year of age-showed that stillbirth remained the commonest category of death in this age group.Key areas of concern included lack of coordinated antenatal risk assessment and referral practices throughout pregnancy, poor recognition and management of the growth restricted baby, issues related to fetal movement (failure to act on reduced movements reported by mothers), communication (lack of planning, poor documentation), and lifestyle issues (smoking, poor attendance).
A Manual of Materia Medica and Pharmacology: Comprising the Organic and Inorganic Drugs which are or have been Recognized by the United States Pharmacopoeia and National Formulary; together with Important Allied Species and Useful Synthetics Especially for Students of Pharmacy and Medicine as well as for Druggists, Pharmacists and Physicians.
Journal: JAMA (1928)

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Trudy I-oy Moskovskoy Psikhiatricheskoy Bolnitsy. Vypusk vtoroy yubileyniy CXXX let
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effects of ethanol administration on components of the ubiquitin proteolytic pathway in rat liver
Authors: L Born
Journal: Hepatology (1996)

Hepatic protein accumulation during ethanol administration may result partly from an ethanol-elicited decline in hepatic protein degradation, which we have previously shown. We conducted the current studies to examine the effects of ethanol administration on the levels of hepatic ubiquitin, an 8.5-kd protein which is an important mediator of extralysosomal protein catabolism. Rats were pair-fed liquid diets containing either ethanol (36% of calories) or isocaloric maltose-dextrin for 1 to 5 weeks. Ubiquitin was immunochemically quantified by competitive enzyme-linked immunosorbent assay (ELISA) in crude cytosol fractions from whole liver and in 12,000g supernatants of hepatocyte lysates. Ubiquitin levels in hepatic cytosol fractions of ethanol-fed rats exceeded those of controls by about 30%. Isolated hepatocytes from ethanol-fed animals also showed a 40% to 75% elevation of ubiquitin above that in cells of pair-fed controls and this difference exceeded the relative rise in hepatocellular protein. In hepatocyte lysates subjected to sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and immunoblotting, we detected monomeric ubiquitin and higher molecular mass ubiquitin-protein conjugates. However, the immunoblot analyses revealed no quantitative changes in the level of either free or conjugated ubiquitin. The ubiquitin conjugating activity of crude and diethyl aminoethyl-fractionated liver cytosols of ethanol-fed rats had equal capacities to those from controls in catalyzing the formation of ubiquitin-protein conjugates. Our findings indicate that chronic ethanol consumption increased the level of immunoreactive ubiquitin in rat liver. This may have resulted from enhanced ubiquitin production because of an ethanol-elicited stress response and/or decreased catabolism of ubiquitin and its conjugates. Our findings also provide no indication that the ethanol-elicited reduction in hepatic proteolysis is because of a ubiquitin-mediated mechanisms.
Carbon Monoxide Poisoning at an Indoor Ice Arena and Bingo Hall—Seattle, 1996
Journal: JAMA (1996)

On March 16, 1996, paramedics and fire department personnel were requested to evaluate complaints of illness among persons exposed to exhaust fumes in an indoor ice skating facility in Seattle. Indoor-air measurements detected elevated levels of carbon monoxide (CO), prompting evacuation of the building. An investigation of the cluster of CO poisonings related to the exposure was conducted March 16-18, by a pulmonary and hyperbaric medicine physician who treated one of the ill persons. This report summarizes the investigation findings, which underscore the importance of adequate maintenance of machinery equipped with internal combustion engines that are operated at indoor ice arenas and of proper ventilation of such arenas.
Diagnostic Radiology
Authors: Harold G. Jacobson
Journal: JAMA (1981)

Dramatic advances in diagnostic radiology have continued during the past year, affecting substantially the practice of medicine in many vital areas. Primarily, these advances lie in interventional radiology, ultrasonography, computed tomography (CT), nuclear radiology, nuclear magnetic resonance (NMR), positron-emission tomography (PET), and computed digital radiography (CDR). Because of limitations of space only a brief description of the more important innovative developments and their clinical applications will be included. Technical details are kept to a minimum. <h3>Interventional Radiology</h3><h3>Angioplasty.—</h3> Percutaneous transluminal angioplasty permits compression of atherosclerotic plaques in an artery by a balloon of fixed diameter, thus enlarging the arterial lumen and increasing blood flow at the site of obstruction. Balloon angioplasty is used currently with considerable success in stenoses (short occlusions) of the renal, iliac, and femoral arteries. Complications are few and are readily managed by the vascular surgeon when they do occur. Angioplasty of the coronary arteries is still
Mammographic parenchymal patterns. Risk indicator for breast cancer?
Authors: L. Tabar
Journal: JAMA (1982)

Mammographic parenchymal patterns, originally presented as a new risk factor for breast cancer, have been prospectively studied in a large (27,157 examinations) consecutive screening population. Although there is a significantly higher risk of breast cancer in the so-called dysplastic breasts (P2 and DY pattern groups), the classification is of little practical value, as more than 72% of the cancers in the prevalent population were found in the so-called low-risk breasts (N1 and P1 pattern groups). A similar trend occurred at repeated screening of younger women, in which most of the "incident" cancers were found in the "low-risk" breasts. These patterns should not be used to influence patient management or screening programs. (<i>JAMA</i>1982;247:185-189)
Less is more and more is less in health care proposals offered in '92 campaign
Authors: P. Cotton
Journal: JAMA (1992)

THE TWO Presidential candidates' health care proposals are painted, in broad brush, as less vs more. Less is promised by an administration that just instituted the most massive medical pricing system in US history, that is accused of micromanaging medicine through a maze of Medicare rules, and that now wants new controls at the National Institutes of Health aimed at steering researchers toward economically advantageous projects. More is the message from a governor who promises to limit overall health care spending, cut off tax deductions for health insurance that goes beyond the basics, and make small businesses buy insurance that some say they cannot afford. Meanwhile, his state's health department is being sued by his state's medical society, miffed that Medicaid payments were cut in Arkansas without the conscientious consultation with physician leaders that the governor had stressed when seeking a health care provider tax. Many voters of all persuasions
Emergency Cardiac Photoscan
Authors: Richard J. Lewis
Journal: JAMA (1968)

The cardiac photoscan is a helpful diagnostic tool for the evaluation of suspected pericardial effusion, particularly with critically ill patients who cannot tolerate angiography. This innocuous procedure can be performed in a few minutes with the use of sodium pertechnetate Tc 99m as the source of radioactivity. In one study, a life-threatening, loculated pericardial effusion was demonstrable only by the photoscan.
TCTAP A-210 Impact of Coronary Artery Fixed Lesion on 3-years Clinical Outcomes in Vasospastic Angina Patients with Myocardial Bridge
Authors: Sang-Ho Park, Seung-Woon Rha, Byoung Geol Choi, Won-Yong Shin, Dong-Kyu Jin, Se Yeon Choi, Yoonjee Park, Akkala Raghavender Goud, Hu Li, Sunki Lee, Ji Bak Kim, Sung Il Im, Jin Oh Na, Cheol Ung Choi, Hong Euy Lim, Jin Won Kim, Eung Ju Kim, Chang Gyu Park, Hong Seog Seo, Dong Joo Oh
Journal: Journal of the American College of Cardiology (2014)
The Albert Lasker Medical Awards. Inositol trisphosphate, calcium, lithium, and cell signaling
Authors: M. J. Berridge
Journal: JAMA (1989)

Inositol lipids play a major role in cell signaling by functioning as precursors of second messengers. Of the three common inositol-containing lipids found in the plasma membrane, phosphatidylinositol (4,5)-bisphosphate is hydrolyzed to give diacylglycerol, which stimulates protein kinase C, and inositol 1,4,5-trisphosphate, which diffuses into the cell to release intracellular calcium. Inositol 1,4,5-trisphosphate is metabolized to give free inositol by two separate pathways. Lithium inhibits the final dephosphorylation step of both pathways, thus reducing the supply of the free inositol required to maintain the lipid precursors used for signaling. An inositol-depletion hypothesis may explain both the teratogenic effects of lithium and its therapeutic action in controlling manic-depressive illness. One of the metabolic pathways generates inositol tetrakisphosphate, which may also play a messenger role by expanding the size of the inositol 1,4,5-trisphosphate—sensitive pool of calcium. Calcium imaging of single cells has begun to reveal that this inositol 1,4,5-trisphosphate/calcium signaling system is organized in complex patterns, which include localization of calcium signals to discrete regions of cells and the generation of both calcium waves and calcium oscillations. (<i>JAMA</i>. 1989;262:1834-1841)
Voyager
Authors: Fiona Miller
Journal: JAMA (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 4297: MYC HIF-2 alpha embryonic stemness genes mediate a transcriptional network to maintain asymmetric self-renewal in oral cancer
Authors: Bidisha Pal, Wael Tasabehji, Sandhya Sorra, Joyeeta Talukdar, Bikul Das
Journal: Cancer Research (2019)

Abstract Cancer Stem Cells (CSCs) explains therapeutic failure across several tumor types. Despite being evolutionarily successful, the extreme ability to self-renew is asymmetric and limited to CSCs in heterogeneous tumor population. Thus, understanding molecular mechanisms maintaining CSCs asymmetric self-renewal would be therapeutically critical.Here, we identified putative molecular transcriptional network that may regulate CSCs asymmetric self-renewal. We developed 4-NQO (4-Nitroquinoline 1-oxide) induced mouse model of oral carcinogenesis that exhibited similar phenotype as human oral cancer. ABCG2+ CSCs enriched from 4-NQO derived mouse tumors and human oral cancer (n=7) patients indicated high expression of embryonic stemness genes such as Nanog, Sox-2, and Oct-4 in addition to MYC and HIF-2a. Higher engraftment potential was observed when ABCG2+ cells were injected to NOD/SCID mice, while HIF-2a silencing markedly increased mice survival during engraftments. ChIP assay revealed preferential binding of MYC to HIF-2a promoter regions in ABCG2+ vs ABCG2- cells. Nanog and Oct4 facilitated MYC binding to HIF-2a while gene silencing of Nanog and Sox2 led to loss of MYC and HIF-2a expression, indicating the possible regulation by MYC and HIF-2a. Further, we utilized clinical data from The Cancer Genome Atlas (TCGA) and demonstrated significant correlation between HIF-2a/MYC and embryonic stemness genes on Structural Equation Modeling Analysis (SEMA) platform, thereby confirming our in vitro/in vivofindings. Thus,our results may provide evidence of a biologically robust stemness transcriptional network regulating the asymmetric self-renewal of ABCG2+ CSCs. Note: This abstract was not presented at the meeting. Citation Format: Bidisha Pal, Wael Tasabehji, Sandhya Sorra, Joyeeta Talukdar, Bikul Das. MYC HIF-2 alpha embryonic stemness genes mediate a transcriptional network to maintain asymmetric self-renewal in oral cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4297.
POISON IN THE BREATH
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Circulating angiogenic factors as predictors of benefit from bevacizumab (bev) beyond progression in metastatic colorectal cancer (mCRC): Translational analyses from the phase III BEBYP trial.
Authors: Chiara Cremolini, Fotios Loupakis, Guido Bocci, Anna Fioravanti, Gianluca Masi, Lisa Salvatore, Federica Marmorino, Paola Orlandi, Marta Schirripa, Teresa Di Desidero, Carlotta Antoniotti, Bastianina Canu, Romano Danesi, Alfredo Falcone
Journal: Journal of Clinical Oncology (2013)

382 Background: TML and BEBYP trials demonstrated that the strategy of prosecuting bev beyond progression is effective in mCRC. Previous analyses from phase II studies showed that a dynamic modulation of plasma angiogenic factors occurs during first-line treatment with chemotherapy (CT) plus bev and a wide variability in soluble Vascular Endothelial Growth Factor Receptor 2 (sVEGFR2) levels was observed at the time of progression. Moving from preliminary analyses in murine models we selected a pool of candidate ligands to be tested in the clinical setting. Methods: sVEGFR2, Placental Growth Factor (PlGF), Platelet-Derived Growth Factor-C, basic Fibroblast Growth Factor, Angiopoietin-2 and sTie-2 were assessed by ELISA on plasma samples collected at baseline in a cohort of 59 patients enrolled in phase III BEBYP trial of 2nd-line CT ± bev beyond progression to a bev-containing first-line regimen. Plasma levels were defined high or low adopting the median as cut-off. Results: A significant interaction between treatment arm and baseline sVEGFR2 levels was observed (p=0.036). Among 30 patients with high sVEGFR2 levels, the prosecution of bev was associated with a significant benefit in terms of PFS (median: 10.4 vs 3.4 months, HR 0.37 [95%CI:0.10-0.58], p=0.0015), that was not evident among 29 patients with low sVEGFR2 levels (5.4 vs 5.0 months, HR 0.98 [95%CI:0.45-2.11], p=0.956). Despite a trend towards a greater benefit from bev among 30 patients with high PlGF levels (HR 0.45 [95%CI: 0.13-0.86]), no interaction between treatment arm and baseline PlGF levels was observed (p=0.210). Combined analysis of sVEGFR2 and PlGF showed that prosecuting bev provided a substantial benefit in PFS in the subgroup with high levels of both ligands (10.5 vs 2.3 months, HR 0.25 [95%CI:0.01-0.45], p=0.043). Conclusions: sVEGFR2 levels at the time of first progression may predict benefit from the prosecution of bev. Impressive results deriving from concomitant testing of sVEGFR2 and PlGF may be affected by excessive subgrouping and should be considered cautiously. Given their potential clinical value these data need prospective confirmation. Clinical trial information: NCT00720512.
Heberden society: combined meeting, September 1982. Abstracts.
Authors: C Hawkins, A Yates, E Hamilton, Dr Boyd, S Lachmann, Mrs Turner
Journal: Annals of the Rheumatic Diseases (1982)

Sports injuries are often dismissed as trivial and self- inflicted.Back injuries interfere with an individual's capacity for work and may cause long-term sequelae.Spina bifida occulta (SBO) is cited in many radiologi- cal texts as of no clinical significance and hence may not be mentioned in x-ray reports.Two hundred and ten cases of lumbar and referred pain were seen in a total of 2269 sports injuries.were performed on 24 children with noninflamma- tory complaints.Most flares were preceded by an infection (Table 3).This was highly significant (X2=20 14, p<0.001).No gross differences were noted in specific antibody titres between patients and control.Interferon responses were not defective, although sequential in vitro IFNa and y responses fluctuated considerably in the same patients.