tbuckley/cabot-search huggingface dataset:
Childhood Influenza-Vaccination Coverage—United States, 2002-03 Influenza Season
Journal: JAMA (2004)

2][3] Beginning in 2002, the Advisory Committee on Immunization Practices (ACIP) encouraged that, when feasible, all children aged 6-23 months, as well as household contacts and outof-home caregivers for children aged Ͻ2 years, receive influenza vaccinations each influenza season. 1 Beginning with the 2004-05 influenza season, ACIP strengthened the encouragement to a recommendation. 4Other children recommended to receive influenza vaccine continue to include those aged 6 months-18 years with certain high-risk medical conditions and those aged 6 months-18 years who are household contacts of persons at high risk for influenza complications. 4 This report on childhood influenza-vaccination coverage for the 2002-03 influenza season provides a baseline for the continuing assessment of coverage among children aged 6-23 months.The findings demonstrate that, during the first year of the ACIP encouragement to vaccinate children aged 6-23 months against influenza, vaccination coverage was low, with substantial variability among states and urban areas.This report is based on data from the 2003 National Immunization Survey (NIS), an ongoing survey that provides estimates of vaccination coverage among noninstitutionalized children aged 19-35 months.Children included in the 2003 NIS were born during January 2000-July 2002.The survey is conducted in all 50 states and 28 selected urban areas. 5In 2003, en-
Abstract 1372: Detection of early stage pancreatic cancer using 5–hydroxymethylcytosine signatures in circulating cell free DNA
Authors: Francois Collin, Yuhong Ning, Gulfem D. Guler, Tierney Phillips, Erin McCarthy, Aaron Scott, Chris Ellison, Chin-Jen Ku, Kim Chau, Alan Ashworth, Stephen R. Quake, Samuel Levy
Journal: Cancer Research (2019)

Abstract Pancreatic cancers are typically diagnosed at late stage where disease prognosis is poor as exemplified by a 5-year survival rate of 8.2%. Earlier diagnosis would be beneficial by enabling surgical resection or earlier application of therapeutic regimens. We investigated the detection of pancreatic ductal adenocarcinoma (PDAC) in a non-invasive manner by interrogating changes in 5-hydroxymethylated cytosines (5hmC) in circulating cell free DNA in the plasma of a PDAC cohort (n=51) in comparison with a non-cancer cohort (n=41). 5hmC profiles from PDAC and non-cancer samples were generated using a previously published modified hMe-Seal protocol that utilizes chemical labeling of 5hmC by β-glucosyltransferase and allows detection of cell free 5hmC from small amounts of cfDNA (1). We found that 5hmC sites are enriched in a disease and stage specific manner in exons, 3’UTRs and transcription termination sites. Our data show that 5hmC density is reduced in promoters and histone H3K4me3 associated sites with progressive disease suggesting increased transcriptional activity. 5hmC density is differentially represented in thousands of genes, and a stringently filtered set of the most significant genes points to biology related to pancreas (GATA4, GATA6, PROX1, ONECUT1) and/or cancer development (YAP1, TEAD1, PROX1, ONECUT1, ONECUT2, IGF1 and IGF2). Regularized regression models were built using 5hmC densities in a comprehensive set of genes with the most variable 5hmC counts and performed with an AUC = 0.94 - 0.96 on training data. We tested the ability to classify PDAC and non-cancer samples with the Elastic net and Lasso models on three independent pancreatic cancer 5hmC data sets (n = 26, 23 and 7) compared with corresponding independent non-cancer cohorts (n =103, 53 and 10), and found validation performance to be AUC = 0.74 - 0.97. The findings suggest that 5hmC changes enable classification of PDAC patients with high fidelity and are worthy of further investigation on larger cohorts of patient samples. Reference: 1. Song, C. - X. et al. 5 - Hydroxymethylcytosine signatures in cell-free DNA provide information about tumor types and stages. Cell Res 27, 1231 (2017). Citation Format: Francois Collin, Yuhong Ning, Gulfem D. Guler, Tierney Phillips, Erin McCarthy, Aaron Scott, Chris Ellison, Chin-Jen Ku, Kim Chau, Alan Ashworth, Stephen R. Quake, Samuel Levy. Detection of early stage pancreatic cancer using 5–hydroxymethylcytosine signatures in circulating cell free DNA [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1372.
Modern Clinical Syphilology: Diagnosis, Treatment, Case Studies
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Progressive Myelopathy
Authors: Mohammad Sarwar
Journal: JAMA (1985)

<h3>To the Editor.—</h3> In the article entitled "Progressive Myelopathy in a 32-Year-Old Man," Dr Chintapalli<sup>1</sup>draws attention to myelopathy caused by ossification of the lower thoracic ligamentum flavum. Although an uncommon occurrence, this entity is an important cause of thoracic cord myelopathy. Whereas this entity can be easily overlooked unless carefully sought for on conventional roentgenograms, it is recognized readily on computed tomographic (CT) scanning. <h3>Report of a Case.—</h3> We recently encountered the case of a 63-year-old man who was initially seen with symptoms and signs pointing to a lower thoracic cord lesion. The patient was investigated from the beginning by magnetic resonance imaging (MRI). Magnetic resonance imaging revealed a low-intensity signal lesion localized to a small part of the dorsal thoracic cord at the T-10 level (Fig 1). This lesion was interpreted as a small vascular lesion, perhaps an arteriovenous malformation (AVM). The physicians requested us to perform spinal
Phase I study of docetaxel and <sup>153</sup>Sm repetitively administered for castrate metastatic prostate cancer (CMPC)
Authors: M. J. Morris, N. Pandit-Taskar, A. J. Amodio, G. A. Gignac, E. Flatts, S. Slovin, D. Solit, D. Rathkopf, S. Larson, H. I. Scher
Journal: Journal of Clinical Oncology (2007)

5152 Background: Docetaxel (Tax) prolongs survival in patients (pts) with CMPC. Early clinical data suggest that Tax combined with bone seeking radiopharmaceuticals may improve survival relative to chemotherapy alone. 153 Sm-lexidronam (Sam) (Quadramet, Cytogen Inc.) is a radiopharmaceutical with a short T 1/2 and a favorable toxicity profile. Methods: Pts with progressive CMPC are treated in cohorts of 3–6. Prior treatment with taxanes is permissible. Cohorts are defined by dose escalations of: Tax 65, 70, 75, 75, 75 mg/m 2 and Sam 0.5, 0.5, 0.5, 0.75, 1 mCi/kg. Each cycle is 6 weeks. Tax is given day 1 and 22 and Sam day -1 to 1 of each cycle. DLT is defined as cycle 1 = grade 3 non-hematologic toxicity, grade 3 neutropenia that lasts for &gt;29 days, or grade 3- 4 anemia or thrombocytopenia of = 5 days. Pts with an ANC of grade 0–1 or platelet count (PLT) of &gt;100,000/mm3 at the end of cycle 1 may receive additional cycles. Pts are treated until progression or toxicity. Results: 18 pts have been treated in 5 cohorts of 3 pts to date. 6 pts were treated in cohort 2. Two pts have not yet received enough treatment to be evaluable. DLT has not yet been reached. The mean number of cycles/pt is 3 (range 1–6). As anticipated, toxicities have primarily been hematologic (see table ). Two pts came off study for hematologic toxicity; one in cohort 2 had grade 3 PLT after 5 cycles and has not recovered at &gt;175 days and 1 pt (cohort 2) failed to recover PLT in the allotted time frame during cycle 4 prohibiting further treatment. No other pts required treatment delays for hematologic toxicity. Mean baseline PSA was 294.6ng/ml with 7/16 (44%) pts achieving = 50% decline in PSA. Conclusions: Coadministration of Tax and Sam has been well tolerated. Repetitive dosing is feasible. Standard approved doses of each drug are being tested in the present (and final) cohort. DLT has not yet been reached. Accrual continues, to refine the optimal dose and schedule in preparation for phase II. Support: Cytogen, Inc., NIH CA102544 [Table: see text] No significant financial relationships to disclose.
Abstract P254: Risk Factors For Venous Thromboembolism in a Cohort of French Women
Authors: Martin Lajous, Laura Tondeur, Agnes Fournier, Francoise Clavel-Chapelon
Journal: Circulation (2012)

Background: There is controversy over whether cardiovascular disease and venous thromboembolism (VTE) share risk factors. Prospective information on risk factors for VTE in otherwise healthy individuals is limited. Methods and Results We evaluated the relation between known risk factors for cardiovascular disease and incidence of VTE among 65,272 French women in the E3N prospective cohort study with no prior history of VTE and who were free of cardiovascular disease or cancer in 1993. All information was self-reported via mailed questionnaires and diet and physical activity were assessed using previously validated instruments. Between 1993 and 2007, 766 cases of deep vein thrombosis or pulmonary embolism were first identified through self-reports and validated using medical records and information from treating physicians. Cases were considered valid if the diagnosis was based on an imaging procedure. We evaluated the following risk factors: education, menopause, postmenopausal hormone use, treated hypercholesterolemia and hypertension, diabetes, body mass index (BMI), physical activity, smoking status and intake of alcohol, red meat, fish, fruits and vegetables, fiber and coffee. In a multivariable model with age as the time scale, we found that, compared to women with a BMI &lt;22 kg/m2, the HR (95%CI) was 1.35 (1.14, 1.60) for 22–24.9 kg/m2, 2.11 (1.73, 2.57) for 25–29.9 kg/m2 and 2.88 (2.08, 3.98) for ≥30 kg/m2 and the p-trend was &lt;0.0001. Menopause was found to be inversely associated with VTE risk [HR=0.60 (95%CI 0.45–0.80); postmenopausal vs. premenopausal women]. In analyses restricted to postmenopausal women, relative to never users current use of postmenopausal hormones was significantly associated to VTE risk [HR=1.44 (95%CI 1.18–1.74)]. No significant association was found with dietary and other cardiovascular risk factors. Conclusion In this large prospective study only some risk factors for cardiovascular disease were associated to VTE incidence. We observed a strong inverse association between menopause and VTE.
<i>Psychopathia Sexualis, with Special Reference to Contrary Sexual Instinct: A Medico-Legal Study.</i>By Dr. R. Von Krafft-Ebing, Professor of Psychiatry and Neurology, University of Vienna. Authorized Translation of the Seventh Enlarged and Revised German Edition, by Charles Gilbert Chaddock, M. D., Professor of Nervous and Mental Diseases, Marion-Sims College of Medicine, St. Louis; Fellow of the Chicago Academy of Medicine; Corresponding Member of the Detroit Academy of Medicine; Associate …
Journal: American Journal of Psychiatry (1893)
'CDC WONDER' computer use revolutionizes acquiring, applying reams of public health data
Authors: C. Marwick
Journal: JAMA (1993)

A REVOLUTION is under way in acquiring, analyzing, and using data of public health significance. Computerized systems are being developed that incorporate public health principles into clinical medicine. Says Andrew Friede, MD, MPH, chief, Public Health Information Systems Branch, Information Resources Management Office, Centers for Disease Control and Prevention (CDC), Atlanta, Ga: "The world is changing. Today we need accurate and timely information, not just data, to make decisions affecting the public health." The focus, Friede told members of the American Public Health Association during their annual meeting in Washington, DC, is "on speeding and simplifying hypotheses about the distribution and determinants of diseases in populations into usable information in ways that will support public health practice." Ultimately, he says, "as these improved computerized data and information systems come into operation they should lead to new ways of thinking and practicing public health." <h3>Real-Time Epidemiology</h3> Not that there is anything
Response by Hu et al to Letter Regarding Article, “Impact of the 2017 ACC/AHA Guideline for High Blood Pressure on Evaluating Gestational Hypertension–Associated Risks for Newborns and Mothers: A Retrospective Birth Cohort Study”
Authors: Jie Hu, Yuanyuan Li, Kathryn M. Rexrode, Shunqing Xu
Journal: Circulation Research (2020)
Deaths and Obituaries.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Intracellular calcium transients underlying interval-force relationship in whole rat hearts: effects of calcium antagonists
Authors: C Zaugg
Journal: Cardiovascular Research (1995)

Objectives: Much of the understanding about the cardiac interval-force relationship of the whole heart, including mechanical restitution and postextrasystolic potentiation (PESP), has been inferred from isolated muscle studies.We tested whether results from isolated muscles about intracellular Ca2' ([Ca2+li) transients underlying the interval-force relationship can be substantiated in whole hearts.Additionally, we investigated whether Ca2+ antagonists could alter [Cazcli transients underlying mechanical restitution and postextrasystolic potentiation.Methods: [Ca2+li transients were studied in isolated perfused rat hearts by surface fluorometry and Indo-1.Using computer-controlled pacing protocols, we performed restitution curves for left ventricular developed pressure and [Ca2+li (developed pressure and [Ca2+], plotted as a function of extrasystolic intervals).To quantify restitution curves, we fitted monoexponential functions to plots and analyzed their shift and slope.Then, we used Ca2+ antagonists, low extracellular Ca2+([Ca2+],) and PESP to modify restitution curves.[Ca'+], transients in isolated rat hearts were interpreted as Ca2+ released from the sarcoplasmic reticulum.Results: Interval-dependent changes in developed pressure were strongly correlated to interval-dependent changes in the amplitude of [Ca2+li transients in isolated whole rat hearts.Additionally, nifedipine and low [Ca2'], led to similar downward shifts but not to a changed slope of restitution curves for [Ca2+li.On the other hand, PESP increased the slope of restitution curves for [Ca*+],.Furthermore, the effect of PESP on developed pressure was blunted by high concentrations of Ca2+ antagonists.Conclusions: The results from isolated muscles about [Ca2+li transients underlying the interval-force relationship could be substantiated in whole hearts.Additionally, low [Ca*+], (induced by nifedipine LX low [Ca2'],) decreased the maximal Ca2+ release of the sarcoplasmic reticulum but did not change the release kinetics.On the other hand, PESP presumably accelerated Ca*+ release kinetics of the sarcoplasmic reticulum.
NECROLOGY.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Case and survival definitions in out-of-hospital cardiac arrest. Effect on survival rate calculation
Authors: T. D. Valenzuela
Journal: JAMA (1992)

<h3>Objective.</h3> —To determine the effect of different case and survival definitions of out-of-hospital cardiac arrest on survival rate calculations. <h3>Design.</h3> —A 22-month case series of nontraumatic, out-of-hospital cardiac arrests. <h3>Setting.</h3> —Southwestern city (population, 400000; area, 390 km<sup>2</sup>) with a two-tiered emergency response system consisting of emergency medical technicians and paramedics. <h3>Patients.</h3> —A consecutive sample of 372 patients found without palpable pulse or spontaneous respiration. <h3>Main Outcome Measures.</h3> —Survival rate after cardiac arrest was calculated using three case definitions of arrest and two definitions of survival. <h3>Results.</h3> —Twenty percent of all patients survived to hospital admission and 6% survived to hospital discharge. Twenty-six percent of adults whose collapse was witnessed survived to hospital admission, and 10% survived to hospital discharge. Patients whose collapse was witnessed and who experienced initial ventricular fibrillation survived to hospital admission in 38% and to hospital discharge in 15% of cases. <h3>Conclusions.</h3> —The survival rate after out-of-hospital cardiac arrest varies widely depending on the case and survival definitions selected. To facilitate intersystem comparison and assessment of interventions designed to improve outcome, the Utstein Consensus Conference recommended that case and survival definitions should be adopted by all prehospital emergency systems. (<i>JAMA</i>. 1992;267:272-274)
Controlled Clinical Evaluations of Chlorine Dioxide, Chlorite and Chlorate in Man
Authors: Judith R. Lubbers, Sudha Chauan, Joseph R. Bianchine
Journal: Environmental Health Perspectives (1982)

To assess the relative safety of chronically administered chlorine water disinfectants in man, a controlled study was undertaken. The clinical evaluation was conducted in the three phases common to investigational drug studies. Phase I, a rising dose tolerance investigation, examined the acute effects of progressively increasing single doses of chlorine disinfectants to normal healthy adult male volunteers. Phase II considered the impact on normal subjects of daily ingestion of the disinfectants at a concentration of 5 mg/l. for twelve consecutive weeks. Persons with a low level of glucose-6-phosphate dehydrogenase may be expected to be especially susceptible to oxidative stress; therefore, in Phase III, chlorite at a concentration of 5 mg/l. was administered daily for twelve consecutive weeks to a small group of potentially at-risk glucose-6-phosphate dehydrogenase-deficient subjects. Physiological impact was assessed by evaluation of a battery of qualitative and quantitative tests. The three phases of this controlled double-blind clinical evaluation of chlorine dioxide and its potential metabolites in human male volunteer subjects were completed uneventfully. There were no obvious undesirable clinical sequellae noted by any of the participating subjects or by the observing medical team. In several cases, statistically significant trends in certain biochemical or physiological parameters were associated with treatment; however, none of these trends was judged to have physiological consequence. One cannot rule out the possibility that, over a longer treatment period, these trends might indeed achieve proportions of clinical importance. However, by the absence of detrimental physiological responses within the limits of the study, the relative safety of oral ingestion of chlorine dioxide and its metabolites, chlorite and chlorate, was demonstrated.
Laboratory Methods, with Special Reference to the Needs of the General Practitioner.
Journal: JAMA (1913)

Apparatus for sputum analysis 28 C Elastic tissue and sputum findings 30 Apparatus for bacteriological examinations 36 A streak culture 38 Correct method of inoculating a tube 39 Surface colonies of diphtheria bacillus 44 Some of the more common forms of the diphtheria bacillus ... 45 Typical fir tree tetanus stab in gelatin 46 Apparatus for blood examinations 52 Development of the blood cells 54 Scheme for rapid counting of red cells 61 1C Spreading 63 Artifacts in blood films 64 Authors' slide forceps 66 Apparatus for stomach analysis 70 Method of removing contents from stomach 73 Microscopic elements of major and minor import in stomach analysis 74 Substitutes for the perfected microtome 79 Apparatus for detection of common poisons 86 Improvised Marsh apparatus 89 Puncture of pleura 95 Diagram showing site of lumbar puncture 96 Apparatus for urinalysis 106 Modification of Boston's pipette test for albumin . . . . ..
Correction
Authors: J Borst, William Fletcher, Shaw Memorial, Miles -Phillips, A Weir, Scottish Branch, R Allen, Glasscock Ltd
Journal: BMJ (1952)

most maternity calls, on the contrary, were at night, between 3 and 4 a.m.; suicides were attempted at all hours of the day and night.The general section of the service, which deals with the non-urgent removal of sick people, conveyed 550,621 patients, covering over three million miles in the process.