tbuckley/cabot-search huggingface dataset:
Sir William Jenner (1815-1898)
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Chronic kidney disease and arrhythmias: highlights from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference
Authors: Christoph Wanner, Charles A. Herzog, Mintu P. Turakhia, Peter J. Blankestijn, Juan-Jesus Carrero, Catherine M. Clase, Rajat Deo, Scott E. Kasner, Rod S. Passman, Roberto Pecoits-Filho, Holger Reinecke, Gautam R. Shroff, Wojciech Zareba, Michael Cheung, David C. Wheeler, Wolfgang C. Winkelmayer
Journal: Kidney International (2018)
HPV-targeted tumor-infiltrating lymphocytes for cervical cancer.
Authors: Christian S. Hinrichs, Sanja Stevanovic, Lindsey Draper, Robert Somerville, John Wunderlich, Nicholas P. Restifo, Richard Sherry, Phan Q Giao, Udai S. Kammula, James C. Yang, Steven A. Rosenberg
Journal: Journal of Clinical Oncology (2014)

LBA3008 Background: Adoptive T-cell therapy (ACT) is a promising cancer treatment modality with potentially broad application. It is not known if ACT can mediate regression of carcinomas, the most common solid tumors in humans. We studied carcinoma of the uterine cervix, a virally induced malignancy that constitutively expresses the HPV E6 and E7 oncoproteins, as a model cancer to test if ACT can mediate regression of an epithelial malignancy. Methods: We initiated a clinical trial to treat metastatic HPV+ cancers with tumor-infiltrating lymphocytes (TIL) selected for HPV E6- and E7-reactivity (HPV-TIL). Patients from the cervical cancer cohort are reported here. HPV-TIL infusion was preceded by non-myeloablative conditioning and followed by high-dose bolus aldesleukin. HPV-reactivity was assessed by ELISPOT, IFN-gamma production, and CD137 expression assays. Results: Nine patients were treated on the study. They received a median of 81 x 109 T cells (range 33 to 159 x 109) as a single infusion. The infused cells possessed reactivity against high-risk HPV E6 and/or E7 in 6/8 patients. The two patients with no HPV reactivity did not respond to treatment. 3/6 patients with HPV reactivity demonstrated objective tumor responses by RECIST (1 PR and 2 CR). One patient had a 39% best response. Two patients with widespread metastases had complete tumor responses that are ongoing 18 and 11 months after treatment. One patient with a complete response had a chemotherapy-refractory HPV-16+ squamous cell carcinoma and the other a chemoradiation-refractory HPV-18+ adenocarcinoma. Both patients demonstrated prolonged repopulation with HPV-reactive T cells following treatment. Increased frequencies of HPV-specific T cells were detectable after 13 months in one patient and 6 months in the other. Two patients with HPV-reactive TIL that did not respond to treatment did not display repopulation with HPV-reactive T cells. Conclusions: HPV-TIL can mediate durable, complete regression of metastatic cervical cancer. Continued investigation of HPV-TIL for cervical cancer, and possibly other HPV+ malignancies, is warranted. Cellular therapy can mediate complete regression of an epithelial malignancy. Clinical trial information: NCT01585428.
Chimica Clinica.
Journal: JAMA (1901)

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Association News.
Authors: H. L. E. Johnson
Journal: JAMA (1900)

<h3>Affliated Societies and the Association.</h3> —The following has been addressed to the secretaries of the different medical societies affiliated with theAmerican Medical Association: <h3>Dear Doctor:</h3> —At a regular meeting of the Committee on National Legislation of theAmerican Medical Association, held Nov. 10, 1899, at Washington, D. C., I was directed to request one delegate to represent your society at the general meeting of delegates to be called by this committee, to meet in Washington, D. C., some time in January or February, 1900, to act in accordance with the resolution adopted by theAmerican Medical Associationat the Columbus meeting, June 7, 1899. Many of the secretaries of the societies have replied promptly, sending in the name and address of their delegate, but a few have as yet not responded. The Legislative Committee hereby respectfully requests the societies that have not furnished us with the name and address
Diagnosis of Diabetes Mellitus
Authors: A. Richard Christlieb
Journal: JAMA (1979)

<h3>To the Editor.—</h3> In the article by Turkington and Weindling entitled "Insulin Secretion in the Diagnosis of Adult-Onset Diabetes Mellitus" (240:833, 1978), the authors suggest that the demonstration of "insulin deficiency should be essential to establish the diagnosis of diabetes mellitus." Their data are interesting and provocative. However, before accepting their interpretation, it appears that several variables in this study were uncontrolled, suggesting that the interpretation of the study be de-emphasized. From a general point of view, the authors tend to stress insulin deficiency in absolute terms as essential in the diagnosis of diabetes mellitus without correlating this with the degree of glycemia, carbohydrate intolerance, or obesity. Many normal persons with relatively low insulin responses clearly do not have hyperglycemic or diabetic complications. Perhaps the authors' conclusions would be more firm if they employed one of the time-honored insulin-glucose relationships. Information concerning glucose levels or glucose tolerance tests during the
RELATION OF TAXATION TO TUBERCULOSIS.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Influence of age on incident diabetes (DM) and cardiovascular disease (CVD) among prostate cancer survivors receiving androgen deprivation therapy (ADT).
Authors: Alicia Katherine Morgans, Kang-Hsien Fan, Tatsuki Koyama, Peter C. Albertsen, Michael Goodman, Ann S. Hamilton, Richard M. Hoffman, Janet L. Stanford, Antoinette M. Stroup, Matthew Resnick, Daniel Ari Barocas, Christina Louise Derleth, David F. Penson
Journal: Journal of Clinical Oncology (2014)

6583 Background: ADT has been associated with increased risk of developing DM and CVD, though this is controversial, particularly for CVD. We prospectively assessed the relationship between ADT and incident DM and CVD in the Prostate Cancer Outcomes Study (PCOS), a population-based cohort of prostate cancer survivors followed longitudinally for 15 years from diagnosis. Methods: We identified men in the PCOS with non-metastatic prostate cancer diagnosed from 1994-1995 and followed through 2009-2010. We used multivariable logistic regression models to compare groups receiving short-term ADT (<2 years), prolonged ADT (≥2 years) and no ADT to assess the relationship between ADT exposure and subsequent diagnoses of DM and CVD (determined by patient report and cause of death data). We evaluated the effects of age at diagnosis, race, stage, and comorbidity on the development of DM and CVD. Results: Among 3,526 men with comorbidity and treatment data, 2985 men without baseline DM and 3,112 men without baseline CVD constituted the DM and CVD cohorts, respectively. Regardless of duration of ADT exposure, there was not an increased risk of DM or CVD in men younger than 70 at diagnosis. Compared to no ADT exposure, prolonged ADT was associated with an increased risk of DM and CVD that increased steadily over age 76 at diagnosis for DM (OR 2.11 at age 74, 95% CI 1.02 – 4.36; OR 2.65 at age 80, 95% CI 1.09 – 6.47) and age 74 at diagnosis for CVD (OR 1.89 at age 74, 95% CI 1.02 - 3.49; OR 3.19 at age 80, 95% 1.25 – 8.17). Increasing comorbidity burden modified risk of DM and CVD (for ≥ 3 comorbidities versus no comorbidities; for DM, OR 4.25, 95% CI 2.3 - 7.9; and for CVD, OR 8.1, 95% CI 4.3 -15.5 P<0.001). Conclusions: The relationship between ADT and development of CVD and DM may be dependent upon age at diagnosis in addition to length of ADT administration, with longer ADT exposure predominantly increasing risk among older men only. Men with greater comorbid burden had increased risk of developing DM and CVD. Younger men with few comorbidities may not have an increased risk of developing DM or CVD despite treatment with ADT.
Follicular dendritic cell sarcoma and interdigitating reticulum cell sarcoma: A review
Authors: R. Fonseca, M. Yamakawa, S. Nakamura, P. van Heerde, M. Miettinen, T.W.H. Shek, O. Myhre Jensen, M.C. Rousselet, A. Tefferi
Journal: American Journal of Hematology (1998)

Neoplasms of reticular dendritic origin are extremely rare and include the follicular dendritic cell sarcoma (FDCS) and the interdigitating reticulum (or dendritic) cell sarcoma (IDCS). In this article, we review the literature pertaining to the two diseases and describe clinical observations and salient pathologic features, including information provided by authors of FDCS and IDDCS reports. We performed a computerized database search for published articles regarding FDCS and IDDCS. The articles were evaluated critically by the authors. Simple descriptive statistics were used to analyze the data. There are 51 cases of FDCS and 21 cases of IDDCS that are well documented in the literature. The pathologic diagnosis of FDCS and IDDCS is often challenging and requires morphologic, immunophenotypic, cytochemical, and electron-microscopic analysis. Patients with FDCS usually present with cervical or axillary lymphadenopathy, but extranodal disease has been described. In at least some patients, preexisting Castleman's disease has been recognized. Resected localized disease may be prevented from recurrence by consolidative radiotherapy. Chemotherapy regimens have shown nondurable antitumor activity in FDCS. Patients with IDDCS usually present with lymphadenopathy. The clinical course of IDDCS has been variable, but it seems to be more aggressive than that of FDCS. Variable degrees of remission may be achieved with chemotherapy. FDCS and IDDCS are rare neoplasms that may pose difficulty in pathologic diagnosis. IDDCS seems to display a more aggressive behavior than FDCS. Patients with IDDCS and FDCS can eventually die of disease progression. The role of chemotherapy and radiotherapy is not clearly defined. Am. J. Hematol. 59:161–167, 1998. © 1998 Wiley-Liss, Inc.
The Diagnosis and Treatment of Peripheral Nerve Injuries. Medical Research Council, First Report of the Committee Upon Injuries of the Nervous System.
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Contents
Authors: R Moreau, R Bataller, T Berg, J Zucman-Rossi, R Jalan, N Weiss, G Dam, C Rose, B De Carvalho, Dominguez Souza, A Ko, A Rasche, I De Oliveira Carneiro, N Stephan, V Corman, P Roppert, N Goldmann, R Kepper, S Mu ¨ller, C Vo, A De Souza, A Moreira-Soto, A Sto, M Nassal, C Franke, J Rebello Pinho, J Soares, P Geyer, C Lemey, E Drosten, D Netto, J Glebe, S Zhu, H Zhang, Y Dong, L Wang, Z Xu, W Liu, Y Gan, H Tang, D Chen, F Wang, P Zhao, G Papatheodoridis, V Sypsa, G Dalekos, C Yurdaydin, F Van Boemmel, M Buti, J Goulis, J Calleja, H Chi, S Manolakopoulos, A Loglio, S Siakavellas, N Gatselis, O Keskın, M Lehretz, S Savvidou, J De La Revilla, B Hansen, A Kourikou, I Vlachogiannakos, K Galanis, R Idilman, M Colombo, R Esteban, H Janssen, P Lampertico, P Bjerring, E Bjerrum, F Larsen, A Kim, D Sinn, W Jeong, Y Kim, T Kang, S Ha, C Park, G Choi, J Kim, C Kwon, J.-W Joh, M.-J Kim, I Sohn, S.-H Jung, S Paik, W Lee, Y.-I Yoon, G.-W Song, S.-G Lee, S Hwang, K.-H Kim, S.-H Kim, W.-H Kang, H.-D Cho, E.-K Jwa, J.-H Kwon, E.-Y Tak, V Kirchner, B Guiu, J.-L Jouve, A Schmitt, A Minello, F Bonnetain, C Cassinotto, L Piron, J.-P Cercueil, R Loffroy, M Latournerie, M Wendremaire, C Lepage, M Boulin, K Mohkam, P.-N Dumont, A.-F Manichon, J.-C Jouvet, L Boussel, P Merle, E De Martin, J.-M Michot, B Papouin, S Champiat, C Mateus, O Lambotte, B Roche, T Antonini, A Coilly, S Laghouati, C Robert, A Marabelle, C Guettier, D Samuel, F Duan, H Wu, D Jia, W Wu, S Ren, S Song, X Guo, F Liu, Y Ruan, J Gu, S Abitbol, R Dahmani, C Coulouarn, B Ragazzon, B Mlecnik, N Senni, M Savall, P Bossard, P Sohier, V Drouet, E Tournier, F Dumont, R Sanson, J Calderaro, M Vasseur-Cognet, P.-A Just, B Terris, C Perret, H Gilgenkrantz
Journal: Journal of Hepatology (2018)
The Glaucomas
Authors: Benjamin H. Ticho
Journal: JAMA (1989)

A fundamental concept in glaucoma is that it represents a variety of conditions that differ markedly in clinical presentation, course, and appropriate treatment. This may cause confusion, for example, when a physician advises against the use of over-the-counter cold medications because they may aggravate glaucoma, without informing patients that this applies only to certain types of glaucoma. This two-volume textbook sorts out the varying kinds of glaucoma (open-angle vs closed, acute vs chronic, primary vs secondary, congenital vs acquired, etc) and provides a comprehensive overview of current glaucoma pathophysiology, diagnosis, and treatment. The expanding knowledge of the various glaucomas over the past decade, as exemplified by the length of this textbook, is unfortunately more than matched by the continuing gaps in the understanding of what causes intraocular pressure to rise and how this leads to visual field loss in affected patients. Frustratingly little is understood about the etiology of open-angle
The Cover
Authors: Virginia Neal Dick
Journal: JAMA (1982)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Measurement of Plasma-Protein Loss into Gastrointestinal Tract Using I131-labelled Proteins and Oral Amberlite Resin
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Evidence Indicates Congenital Anomalies Are Main Cause for Spontaneous Abortion
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Evaluation of circulating tumor cell (CTC) enumeration as an efficacy response biomarker of overall survival (OS) in metastatic castration-resistant prostate cancer (mCRPC): Planned final analysis (FA) of COU-AA-301, a randomized double-blind, placebo-controlled phase III study of abiraterone acetate (AA) plus low-dose prednisone (P) post docetaxel.
Authors: H. I. Scher, G. Heller, A. Molina, T. S. Kheoh, G. Attard, J. Moreira, S. K. Sandhu, C. Parker, C. Logothetis, R. T. McCormack, K. Fizazi, A. Anand, D. C. Danila, M. Fleisher, D. Olmos, C. M. Haqq, J. S. De Bono
Journal: Journal of Clinical Oncology (2011)

LBA4517^ The full, final text of this abstract will be available in Part II of the 2011 Annual Meeting Proceedings, distributed onsite at the Meeting on June 4, 2011, and as a supplement to the June 20, 2011, issue of Journal of Clinical Oncology.
Contents
Authors: Jennifer Thorne, Fasika Woreta, Douglas Jabs, Grant Anhalt, Barbara Nemesure, Suh-Yuh Wu, Anselm Hennis, M Leske, Yan Li, David Meisler, Maolong Tang, Ake Lu, Vishakha Thakrar, Bibiana Reiser, David Huang, Clement Tham, Yolanda Kwong, Dexter Leung, S Lam, Felix Li, Thomas Chiu, Jonathan Chan, Catherine Chan, Agnes Poon, Doris Yick, C Chi, Dennis Lam, Jimmy Lai
Journal: Ophthalmology (2008)