tbuckley/cabot-search huggingface dataset:
Miscellany
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Malingering
Authors: Warren F. Gorman
Journal: JAMA (1983)

<h3>To the Editor.—</h3> In an article entitled "Reliability and Validity of American Medical Association's Guide to Ratings of Permanent Impairment" by D. S. Gloss, PhD, and M. G. Wardle, PhD (1982;248:2292), the authors close with a cautionary note on malingering, stating that their rating "scale is not immune from malingering or, more likely, exaggeration of a claim." This contradicts or ignores the usual and accepted definition, which states that malingering is either the simulation<i>or</i>the exaggeration of physical or psychological symptoms.<sup>1</sup> A forensic physician proposed that malingering is a wrongful act, performed with the intent to commit civil or criminal fraud, and noted that the mental status of the malingerer may vary from that of a normal person to any form of diagnosable mental disorder.<sup>2</sup>
Reproductive Toxicity of the Industrial Solvent 2-Ethoxyethanol in Rats and Interactive Effects of Ethanol
Authors: B. K. Nelson, W. Stephen Brightwell, James V. Setzer, Thomas L. O'Donohue
Journal: Environmental Health Perspectives (1984)

The solvent, 2-ethoxyethanol, induced complete embryomortality in pregnant rats exposed to three times the current Federal permissible exposure limit (PEL). Following exposure to ethoxyethanol at a concentration only one-half the current PEL, the offspring evidenced behavioral and neurochemical deviations from controls. Subsequent studies found that ingestion of ethanol with concomitant inhalation of ethoxyethanol vapors early in pregnancy appeared to reduce the number of both behavioral and neurochemical deviations found for ethoxyethanol. In contrast, the concomitant exposure to ethanol and ethoxyethanol later in gestation potentiated the behavioral and neurochemical effects of ethoxyethanol. This research indicates that the industrial solvent 2-ethoxyethanol presents an occupational reproductive hazard and raises the issue of the importance of an interaction of social habits with occupational exposure to such hazards. The results would suggest that occupational physicians should advise pregnant workers in the chemical industry of the adverse effects of ethanol during pregnancy and of the possible interactions with other chemicals and should encourage them to be especially cautious with ethanol consumption since they may be at greater risk.
The Audiphone and How to Use It in Hearing Through the Teeth.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 3775: Cardiomyocyte-Specific Deletion of Inhibitor of Kappa-B Kinase-β (IKKβ) In Vivo Reveals Essential Role in Calcium Handling
Authors: Noboru Ashida, Matthew Coggins, Jianru Shi, Bo Wang, Federica del Monte, Ronglih Liao, Anthony Rosenzweig
Journal: Circulation (2008)

The serine-threonine kinase, IKKβ, is required in most settings for activation of NF-κB transcription factors, which regulate a wide range of essential processes from cell survival to inflammation. In the heart, while IKKβ and NF-κB are activated in many diseases conditions, whether this activation is adaptive or deleterious remains unclear. To determine the role of IKKβ in the heart, we generated cardiac-specific knockout mice utilizing cardiomyocyte (CM)-specific expression of either Cre or an activatable Cre-fusion protein, producing constitutive (c) or tamoxifen-inducible (i) cardiac-specific IKKβ knockouts (CSIKO), respectively. cCSIKO were born at the expected Mendelian frequency and developed normally. IKKβ expression was dramatically reduced in both cCSIKO and (after tamoxifen) iCSIKO hearts. As expected, CM NF-κB activation after in vivo LPS treatment was markedly impaired in both cCSIKO and iCSIKO mice. Interestingly, both lines had cardiac dysfunction. No evidence of increased apoptosis was observed by TUNEL staining in cCSIKO. Studies in isolated CM from cCSIKO demonstrated reduced decreased peak shortening (2.3% vs. 3.7%) and calcium transient amplitude (0.30 vs 0.46, p&lt;0.03 for both) without a change in normalized kinetics. Protein expression of the calcium handling proteins (L-type calcium channel [LTCC], calsequestrin, sodium-calcium exchanger, and phospho- to dephosphorylated ryanodine receptors) was unchanged in whole heart lysates. However confocal immunohistochemistry demonstrated a markedly abnormal distribution of the LTCC α2 subunit in CSIKO hearts despite intact T-tubules and dyads by electron microscopy. In conclusion, conditional deletion of IKKβ reveals an essential and unanticipated role in regulating CM calcium handling that appears mediated by alterations in LTCC subunit trafficking. Understanding the role of IKKβ and NF-κB in regulating cardiac function has important practical implications for therapeutic strategies targeting this pathway.
Humoral Regulation of Erythropoiesis. XI. Pattern of Response to Specific Therapy in Iron Deficiency Anemia
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Natural Selection
Authors: Jackson A. Smith
Journal: JAMA (1962)

<h3>To the Editor:—</h3> <i>JAMA</i>'s new format seems to be more than cover deep. Lately, we've learned that M.D.'s are in danger of becoming extinct because medical students are untaught in the gentle arts of propagation. Next we hear of the new scientific discovery that the female breast has a function (<i>JAMA</i><b>180</b>:826 [June 9] 1962). This revelation is almost enough to set one to regressing—after being taught in medical school that breasts were only there to help support the brassiere business and to keep the tassels in orbit at burlesque shows. You just don't find this kind of erudition outside of comic books very often. Particularly refreshing was the observation that fat women have a following in cold climates. (Were they decimated by the introduction of the hot water bottle?) Thin women are apparently more in demand in the tropics—if things get too hot you can always use
Electron-Spin Resonance Study of Mainstream and Sidestream Cigarette Smoke: Nature of the Free Radicals in Gas-Phase Smoke and in Cigarette Tar
Authors: William A. Pryor, Donald G. Prier, Daniel F. Church
Journal: Environmental Health Perspectives (1983)

Radicals in the gas phase of both mainstream and sidestream cigarette smoke have been studied using electron-spin resonance ESR spin-trapping techniques with alpha-phenyl-N-tert-butyl nitrone (PBN) as the spin trap. The principal radicals we trap appear to be alkoxyl radicals. Mainstream and sidestream gas-phase smoke each have about the same concentration of radicals, about 1 X 10(16) radicals per cigarette (or 5 X 10(14) per puff). These radicals are reactive, yet they appear to be remarkably long-lived: they are still spin trapped from gas-phase smoke after more than 5 min. We propose that a steady-state concentration of reactive radicals exists in gas phase cigarette smoke. We suggest that this steady state is produced by the slow oxidation of nitric oxide (present in high concentrations in smoke and relatively unreactive) to the more reactive nitrogen dioxide, followed by the reaction of nitrogen dioxide with reactive organic molecules in smoke (such as olefins and dienes). Preliminary experiments reported here support this hypothesis. Tar from both mainstream and sidestream smoke contains persistent free radicals that exhibit broad, single-line ESR spectra with g values of 2.003. The tar radical can be extracted into tert-butylbenzene and other organic solvents, and we have applied a variety of fractionation procedures to these solutions. Most of the radicals occur in the fractions that contain the phenolic tobacco leaf pigments. Treatment of alcoholic solutions of tar with base generates a new group of radicals that appear to be semiquinone radicals derived from the oxidation of the phenolic and polyphenolic species in tar.
The Effects of the Economic Depression on Education in Other Countries
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BOOK REVIEWS
Authors: G. DAVID ROODMAN
Journal: JNCI Journal of the National Cancer Institute (1989)

BOOK REVIEWS Get access Pure Red Cell Aplasia. Emmanuel N. Dessypris. Baltimore: The Johns Hopkins University Press, 1988, 160 pp. $32.50. G. DAVID ROODMAN G. DAVID ROODMAN Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 81, Issue 13, 5 July 1989, Page 1040, https://doi.org/10.1093/jnci/81.13.1040 Published: 05 July 1989
Neuritis and Neuralgia.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Myocardial PKC epsilon, but not PKC beta, activation is mechano-sensitive and plays a compensatory role in ventricular hypertrophy in hypertensive rats Koichi Inagaki, Yasuki Kihara, Wataru Hayashida, Yoshitaka Iwanaga, Asuka Yasaka, Shigetake Sasayama. Kyoto University Graduate School of Medicine, Kyoto, Japan
Journal: Journal of the American College of Cardiology (2001)
1. Improving Care and Promoting Health in Populations: <i>Standards of Medical Care in Diabetes—2021</i>
Authors: American Diabetes Association
Journal: Diabetes Care (2020)

The American Diabetes Association (ADA) “Standards of Medical Care in Diabetes” includes the ADA's current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA Professional Practice Committee, a multidisciplinary expert committee (https://doi.org/10.2337/dc21-SPPC), are responsible for updating the Standards of Care annually, or more frequently as warranted. For a detailed description of ADA standards, statements, and reports, as well as the evidence-grading system for ADA's clinical practice recommendations, please refer to the Standards of Care Introduction (https://doi.org/10.2337/dc21-SINT). Readers who wish to comment on the Standards of Care are invited to do so at professional.diabetes.org/SOC.
Vitamin D Deficiency in Homebound Elderly Persons
Authors: S. Elizabeth Whitmore
Journal: JAMA (1996)

<h3>To the Editor.</h3> —The study by Dr Gloth and colleagues<sup>1</sup>may be incorrectly interpreted as implying that because of outdoor exposure, nonhomebound elderly persons are not at risk for vitamin D deficiency. Reduced serum 1,25-dihydroxyvitamin D<sub>3</sub>and increased parathyroid hormone (PTH) levels were detected in the homebound ill relative to the non-homebound healthy elderly individuals. It was concluded that "homebound elderly persons are likely to suffer from vitamin D deficiency," imparting the impression that nonhomebound elderly individuals are not at risk because of outdoor exposure. Instead, this lack of deficiency may have been dependent on adequate vitamin D ingestion or serum sampling favoring seasons when routine outdoor exposure (ultraviolet B radiation) in Baltimore, Md, yields sufficient cutaneous vitamin D synthesis. Although vitamin D ingestion was quantified and the above serum levels studied were not significantly different by season for the homebound elderly, this information regarding the nonhomebound controls
Lithotripsie guidée par cholangioscopie pour extraction difficile des calculs des voies biliaires en une seule séance de CPRE: les résultats dʼun grand registre multinational montrant des taux de réussite élevés
Journal: Endoscopy (2019)

Maydeo et al rapportent les résultats de leur étude multicentrique, non comparative sur l’efficacité de la lithotripsie intracorporelle (LIC) par cholangioscopie (Spyglass®, Boston Scientific) pour des calculs biliaires “difficiles”, définis par au moins un des critères suivants: taille ≥ 15 mm, échec d’extraction par cholangiopancréatographie rétrograde (CPRE) utilisant les techniques courantes d’extraction (macrodilatation et/ou LIC mécanique et/ou stenting), caractère enclavé du calcul, calculs multiples, calcul(s) intra-hépatique(s) ou en amont d’une sténose biliaire.
Crosslineage T-Cell Receptor Genes Rearrangements and Active Receptor Editing in B-Cell Acute Lymphoblastic Leukemia.
Authors: Hanna Makuch-Lasica, Miroslaw Majewski, Grazyna Nowak, Iwona Kania, Monika Lewandowska, Lech Konopka, Krzysztof Warzocha
Journal: Blood (2007)
The Oldest Woman Physician in England
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ureteroceles in children. A simplified and successful approach to management
Authors: L. R. King
Journal: JAMA (1983)

This review documents the success that we have experienced in treating most ureteroceles that present in children by heminephroureterectomy. If excision of the ureterocele is required, or reimplantation of a ureter other than the ureter obstructed by the ureterocele, this is deferred until the degree of hydronephrosis is reduced or bladder thickening and trabeculation have returned toward normal. In instances where there is function in the upper pole segment obstructed by the ureterocele, ureteropyelostomy has enabled us to preserve renal function by removing the obstructed ureter to permit the ureterocele to collapse.
Identification of independent primary tumors and intra-pulmonary metastasis using DNA rearrangements in non-small cell lung cancer.
Authors: Stephen J Murphy, Marie-Christine Aubry, Faye R Harris, Sarah H Johnson, Simone Barreto Siqueira Parrilha Terra, Michael Asiedu, Tobias Peikert, Ping Yang, Eunhee S. Yi, George Vasmatzis, Dennis A. Wigle
Journal: Journal of Clinical Oncology (2014)

e18515 Background: Distinguishing independent primary tumors from intrapulmonary metastases remains a clinical dilemma, with significant impact regarding treatment approach. We have developed a sequencing-based approach using chromosomal rearrangements to distinguish between these clinical scenarios. Methods: Tumor specimens from cases of known synchronous primaries and metastatic lesions were used for lineage test development, which was then applied to multifocal cases. Laser capture microdissection was performed separately for each tumor. Genomic DNA was isolated using direct in situ whole genome amplification methodology, and next generation sequencing performed using an Illumina mate pair library protocol. Sequence reads were mapped to the human genome and primers spanning the fusion junctions were used for validation PCR. Results: A total of 44 tumor samples were sequenced (35 ADC and 9 SqCC), with a range of 3-276 breakpoints per tumor identified. Lung tumors predicted to be synchronous primaries based of different histologic subtype did not share any genomic rearrangements. In cases of lung primary and paired distant metastasis, shared rearrangements were identified in all cases, emphasizing the patient and tumor specificity of the identified breakpoints. Cases of multifocal ADC were reviewed independently by 2 pulmonary pathologists, with discrepant and indeterminate cases resolved by genome sequencing. Conclusions: A diagnostic lineage test based on genomic rearrangements from mate-pair sequencing demonstrates promise for distinguishing synchronous primary from metastatic disease in lung cancer.
ECG Response: May 20, 2014
Authors: Philip Podrid
Journal: Circulation (2014)

ECG Challenge: A 66-year-old man with a history of hypertension and hyperlipidemia presents with substernal chest burning that he felt was gastrointestinal related because it occurred shortly after lunch.However, antacids were without benefit.After 4 to 5 hours, he decided to go to an emergency room.On the basis of ECG abnormalities and elevated serum troponin and creatine kinase-MB, he was brought to the cardiac catheterization laboratory.One-vessel disease (right coronary artery) was noted, and a percutaneous coronary intervention was performed.There is a regular rhythm at a rate of 50 bpm.There is a P wave before each QRS complex (+) with a stable but short PR interval (0.12 second).The P waves are abnormal in that they are negative in leads II, aVF, and V 3 through V 6 .Hence, the rhythm is not a sinus but an atrial rhythm.There is ST-segment elevation in leads II, III, and aVF (▼).In addition, there are T-wave inversions in these leads (▲).The ECG shows an acute inferior wall ST-segment-elevation myocardial infarction.Along with this, there are ST-segment depressions in leads I and aVL (^), which are reciprocal changes seen with an acute ST-segment elevation inferior wall myocardial infarction.Also noted is ST-segment elevation in leads V 1 and V 2 (↓).When associated with an acute inferior wall