tbuckley/cabot-search huggingface dataset:
From the Food and Drug Administration
Authors: S. L. Nightingale
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CRIMINAL MORPHOMANIA.
Authors: T. D. CROTHERS
Journal: JAMA (1899)

The physiologic action of opium and its alkaloids, with symptomatologies, is becoming more familiar with the increasing frequency of cases and studies of many persons. As in other fields of research, there are vast stretches of unknown lands awaiting discovery, and many new facts in the etiology, progress and treatment to be seen and described. My purpose is to point out a new phase in the symptomatology, and describe a condition which has been noticed, but not defined or studied before. I shall use the term "palsy of the higher psychic centers" to describe in part this condition. The former personality of the person is lost, and he acts from a different point of view; his conduct and thoughts vary widely from former conditions, and he seems to have new purposes and changing motives, foreign to any previous life. These strange inconsistencies of conduct and thought come into legal notice, in the question of responsibility in crime.
CLINICAL SPIROMETRY AND THE VITAL CAPACITY OF THE LUNGS
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Muscular Dystrophy
Authors: Fred A. Ziter
Journal: JAMA (1983)

This book consists of the proceedings of the International Symposium on Muscular Dystrophy held in Tokyo in November 1980. A group of international participants joined researchers from Japanese laboratories to describe their research in 38 papers covering a broad range of topics, including animal dystrophy, muscle development, tissue culture and transplantation, muscle protein metabolism, dystrophic membrane defects, and clinical diseases. Interesting data are presented on the biochemical changes in chicken dystrophy muscle and the glycogen storage disorder of Japanese quails, a form of acid maltase deficiency. Lucid characterization of several muscle proteases and elegant studies of altered dystrophic membrane ultrastructure add support to the hypotheses that these factors are of fundamental importance in dystrophy pathogenesis. Clinical reports deal with several disorders, including congenital muscular dystrophy, phosphofructokinase deficiency, and oculopharyngeal and Duchenne's dystrophies. A unique form of distal muscular dystrophy and a new myopathy, lactic dehydrogenase-M subunit deficiency, are carefully documented.
THE TRAINING OF HOSPITAL EXECUTIVES
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
"BECLOMETHASONE/FORMOTEROL VERSUS BUDESONIDE/FORMOTEROL COMBINATION THERAPY IN ASTHMA". A. PAPI, P.L. PAGGIARO, G. NICOLINI, A.M. VIGNOLA AND L.M. FABBRI ON BEHALF OF THE INHALED COMBINATION ASTHMA TREATMENT VERSUS SYMBICORT (ICAT SY) STUDY GROUP. EUR RESPIR J 2007; 29: 682-689.
Journal: European Respiratory Journal (2007)

Unfortunately, a small section of text in the above paper (in the Discussion, paragraph four) was reported incorrectly.The sentence ''Apart from case B, who was suffering from disseminated M. tuberculosis complex infection, no patients described in the present report were likely to be immunocompromised.''should read ''Apart from case B, who was suffering from disseminated MOTT infection, no patients described in the present report were likely to be immunocompromised.''
Left ventricular hypertrophy in black and white hypertensives. Standard electrocardiographic criteria overestimate racial differences in prevalence
Authors: D. K. Lee
Journal: JAMA (1992)

<h3>Objective.</h3> —To assess racial differences in the accuracy of standard electrocardiographic (ECG) criteria in the diagnosis of left ventricular hypertrophy (LVH). <h3>Design.</h3> —The sensitivity and specificity of standard ECG criteria were compared in blacks and whites using echocardiographic LVH as the reference standard. <h3>Setting.</h3> —Eight worksite-based hypertension clinics in New York, NY. <h3>Patients.</h3> —A sample of 122 black and 148 white hypertensive patients. <h3>Results.</h3> —The prevalence of ECG-LVH was two to six times higher in blacks than in whites, depending on the criteria used (range, 6% to 24% in blacks vs 1% to 7% in whites;<i>P</i>=.0005 to .19 for black-white comparisons). The difference in prevalence of ECG-LVH, however, was less striking and did not attain statistical significance (26% in blacks and 20% in whites;<i>P</i>&gt;.2). The sensitivity of the ECG was low (range, 3% to 17%) and did not differ significantly between the two races for any of the conventional criteria; specificity, however, was lower in blacks for all criteria (range, 73% to 94% vs 95% to 100% for whites;<i>P</i>=.0001 to .09). The predictive value of a positive ECG was consistently, although not significantly, lower in the black subjects. Black race was the strongest independent predictor of decreased ECG specificity in multiple logistic regression analysis that also considered age, gender, body mass index, left ventricular mass index, and smoking. <h3>Conclusions.</h3> —Commonly used ECG criteria for the detection of LVH have a poor sensitivity in both black and white hypertensives and a lower specificity in blacks than in whites; this may lead to a greater number of false-positive diagnoses in black patients, as well as to an overestimation of black-white difference in LVH prevalence. (<i>JAMA</i>. 1992;267:3294-3299)
Detection of cardiac abnormality by clinical measurement of left ventricular ejection time. A prospective study of 200 unselected patients
Authors: D. H. Spodick
Journal: JAMA (1969)

Left ventricular ejection time (LVET) was measured without prior knowledge of clinical data from the carotid pulse curves of 200 unselected patients. Plotted against heart rate, LVET was abnormally low in 77 of 97 patients with heart disease; it was normal in 92 of 103 noncardiac patients. A regression equation for ejection time vs heart rate for the noncardiac patients differed from the equation for healthy ambulant persons, indicating that "hospital normals" differ from individuals free of any recognizable illness. The clear separation of most "normals" from "abnormals" by blindly determined LVET tends to confirm results of previous studies demonstrating that technically good curves can be measured accurately at electrocardiographic paper speed (25 mm/sec). Left ventricular ejection time appears to be a simple, nontraumatic screening test for cardiac malfunction which can be applied by physicians or ECG technicians.
Pimping
Authors: William C. Beck
Journal: JAMA (1990)

<h3>To the Editor.—</h3> In the November 10, 1989, Letters column, Dr Kleinman<sup>1</sup>quite correctly calls attention to the fact that the word<i>pimping</i>does not exist in any dictionary. Lest this word, possibly used as a sensational catchword, become a neologism, I would like to call attention to an error that must have occurred and that I cannot understand escaped your reviewers. What is obviously meant is<i>pumping</i>. It is found in all dictionaries defined as "to question persistently." In its milder and more modern form it is referred to as "debriefing." The German word that Dr Brancati misused is the same<i>pumpe</i>— without an umlaut. It has the identical meaning to its English counterpart and was much used with respect to the interrogation of prisoners. I have no reason to believe that William Harvey would have used a word with as bad a connotation as "pimp"
BOOKS FOR PHYSICIANS
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Highlights
Journal: JAMA Psychiatry (2016)

Correction Research Aripiprazole Augmentation for Late-Life Depression 329More than half of older adults with major depressive disorder fail to respond adequately to fi rst-line treatment.Kaneriya and colleagues studied predictors and moderators of remission in a 12-week clinical trial of aripiprazole in adults 60 years and older who had not remitted with venlafaxine.Poor set-shifting performance at baseline identifi ed a group of patients who were unlikely to benefi t from adjunctive aripiprazole treatment.In an editorial, Taylor discusses the implications of identifying moderators of remission in late-life depression.
Reply
Authors: Sudeep Banerjee, Michael D. Kuo
Journal: Hepatology (2016)

Potential conflict of interest: Nothing to report. REPLY: We appreciate the interest and comments of Dr. Tang and colleagues in our study.1 In our cohort, the prevalence of cirrhosis in patients who underwent orthotopic liver transplantation was significantly greater than in those who were surgically resected (96.4% versus 38.8%, P < 0.001). As Dr. Tang et al. highlight, there is a difference in the sensitivity of the radiogenomic venous invasion (RVI) biomarker between the surgical resection and orthotopic liver transplantation subgroups (84% versus 66.7%), which is potentially due to obscuration of imaging traits by underlying liver disease. However, it is important to note that this difference in sensitivity was not associated with a concomitant drop in specificity (95.7% versus 92.3%, respectively). This suggests that although it is possible that underlying cirrhosis may interfere with identification of RVI traits, there is minimal risk that a patient would be falsely attributed an RVI‐positive status. This distinction is clinically important because RVI may be used to identify patients who would be unlikely to derive survival benefit from transplantation, but it is unlikely to adversely affect transplant eligibility in patients without microvascular invasion (MVI). The second comment by Dr. Tang et al. pertains to the role of needle‐core biopsy (NCB) in detecting MVI. In our study, NCB had poor sensitivity in detecting MVI compared with RVI (12.5% versus 87.5%). As supporting evidence, we cite Pawlik et al., who examined the correlation of nuclear grade based on NCB and the presence of MVI in explant pathology.2 They found that nuclear grade based on NCB was a poor predictor of MVI, whereas nuclear grade on explant pathology strongly correlated with the presence of MVI. Although the role of NCB in detecting MVI was not directly addressed, the data suggest that NCB is an unreliable basis for determining histologic characteristics of hepatocellular carcinoma. The inadequacies of NCB underscore the importance of preoperative diagnostic tools that capture global tumoral phenotypes such as RVI.
Synthesis of insulin-like growth factor binding proteins and of acide-labile subunit in cultured rat hepatocytes, Kupffer cells and cocultures: Regulation by insulin, IGF-I and growth hormone Depts. of Medicine and *Biochemistry H; Georg-August-Universit�t, G�ttingen, Germany
Journal: Hepatology (1995)

To determine if human oviduct expresses messenger ribonucleic acids (mRNAs) encoding insulin-like growth factor binding proteins (IGFBPs), if oviductal epithelium secretes IGFBPs into conditioned medium (CM), and if IGFBP secretion is regulated by steroid hormones.Northern blots of RNA, isolated from late proliferative phase human fimbria and oviductal isthmus, were probed with complementary deoxyribonucleic acids encoding IGFBP-1, IGFBP-2, IGFBP-3, and IGFBP-4. In addition, oviductal ampullary epithelial cells were cultured with and without estrogen and/or progesterone (P), and IGFBPs were examined in CM by Western ligand blot analysis and identified using specific antisera.Tissue was obtained from hysterectomy specimens at Stanford University Hospital, a private teaching institution.Patients undergoing hysterectomy for benign disease.None.Transcripts of IGFBP mRNA and IGFBPs secreted into CM were detected by autoradiography of Northern and Western ligand blots, respectively.Messenger RNA transcripts encoding IGFBP-2, -3, and -4 were detected, whereas IGFBP-1 mRNA was barely detectable in oviductal tissue. In CM, IGFBP-2 and IGFBP-3 were detected, as was a unique 24–kd IGFBP, although IGFBP-1 was not observed. Estrogen and/or P did not regulate the secretion of these IGFBPs by cultured oviductal epithelium.Human oviduct expresses mRNAs encoding IGFBP-2, IGFBP-3, and IGFBP-4, and in vitro oviductal epithelium secretes IGFBP-2, IGFBP-3, and a unique binding protein of 24 kd, which may be the recently identified IGFBP-4.
Community Health Organization: A Manual of Administration and Procedure for Cities of 100,000, With Suggested Modifications for Larger and Smaller Urban Units.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
What's new in the other general journals
Authors: Alison Tonks
Journal: BMJ (2006)

People with AIDS are living longer, thanks to highly active retroviral treatment, and an increasing proportion are surviving their infection long enough to die of unrelated illnesses such as cardiovascular disease. This is certainly true in New York city, where recent research shows that more than a quarter of people with AIDS die from something else—mostly drug overdose, heart disease, or a cancer unrelated to HIV infection. Credit: ANN INT MED This proportion increased by a third (from 19.8% to 26.3%, P = 0.015) between 1999 and 2004. The authors and a linked editorial agree there is a growing need for doctors to take a more holistic view of people with AIDS, possibly by focusing less on their infection and more on their general health. Both suggest shifting the care for these patients towards primary care, in which people with AIDS would benefit from standard practices, such as advice about quitting smoking and other drugs, cancer screening, and chronic disease management for hypertension and diabetes. Credit: JAMA In the five years of this study, annual mortality in people with AIDS fell faster for deaths related to HIV than for deaths from other causes, but a low CD4 count was an effective predictor for both. Injecting drug users had higher mortality than gay men. Credit: LANCET Ann Int Med2006;145: 397–406. [OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] Many pregnancies complicated by pre-eclampsia now end in deliberate preterm delivery of the infant. Delivery cures the pre-eclampsia and may prevent a stillbirth, but it exposes the infant to all the risks of being born too early. Has the trend towards earlier intervention saved babies, or simply shifted their deaths from the womb to the postnatal period? Observational data from Norway's almost complete register of births is encouraging. In a study of all first singleton births between 1967 and 2003, the risk of stillbirth fell … [1]: {openurl}?query=rft.jtitle%253DAnnals%2Bof%2BInternal%2BMedicine%26rft.stitle%253DANN%2BINTERN%2BMED%26rft.issn%253D0003-4819%26rft.aulast%253DSackoff%26rft.auinit1%253DJ.%2BE.%26rft.volume%253D145%26rft.issue%253D6%26rft.spage%253D397%26rft.epage%253D406%26rft.atitle%253DCauses%2Bof%2Bdeath%2Bamong%2Bpersons%2Bwith%2BAIDS%2Bin%2Bthe%2Bera%2Bof%2Bhighly%2Bactive%2Bantiretroviral%2Btherapy%253A%2BNew%2BYork%2BCity.%26rft_id%253Dinfo%253Adoi%252F10.7326%252F0003-4819-145-6-200609190-00003%26rft_id%253Dinfo%253Apmid%252F16983127%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.7326/0003-4819-145-6-200609190-00003&link_type=DOI [3]: /lookup/external-ref?access_num=16983127&link_type=MED&atom=%2Fbmj%2F333%2F7570%2F699.atom [4]: /lookup/external-ref?access_num=000240752500001&link_type=ISI
Abstract P274: FGF-23 is Associated with Left Ventricular Hypertrophy and Systolic Dysfunction among Patients with Coronary Heart Disease: The Heart and Soul Study
Authors: Isha Agarwal, Joachim Ix, Bryan Kestenbaum, Nelson Schiller, Mary Whooley, Kenneth Mukamal
Journal: Circulation (2013)

Introduction: Fibroblast growth factor-23 (FGF-23) is a bone-derived phosphaturic hormone strongly associated with cardiovascular mortality and left ventricular hypertrophy among individuals with end-stage renal disease (ESRD). Whether the relationship between FGF-23 and cardiac dysfunction extends to participants without ESRD is not clearly established. Hypothesis: We tested whether FGF-23 is associated with left ventricular mass index (LVMI) and left ventricular ejection fraction (LVEF) in participants with coronary heart disease (CHD) and a broad range of kidney function in the Heart and Soul Study. Methods and Results: In cross-sectional analyses of 887 participants of the Heart and Soul Study, FGF-23 was positively associated with LVMI (2.09 g/m 2 , 95% confidence interval [CI] 0.15 to 4.03 per 1 standard-deviation [SD] higher ln FGF-23) and inversely associated with LVEF (-0.96%, CI -1.71% to -0.21%, per 1 SD higher ln FGF-23) after adjustment for age, CHD risk factors, microalbuminuria, and cystatin-based estimated glomerular filtration rate (eGFR). In multinomial logistic regression, FGF-23 was associated with an increased prevalence of concentric hypertrophy (odds ratio 1.66, CI 1.00 to 2.76, per 1 SD increase in ln FGF-23) but not eccentric hypertrophy (odds ratio 1.14, CI 0.96 to 1.36). The association between FGF-23 and concentric hypertrophy was stronger among individuals with an estimated GFR &lt; 60 mL/min per 1.73 m 2 , and was not statistically significant among individuals with normal to mildly reduced kidney function (Figure, p interaction 0.11). Conclusion: In conclusion, FGF-23 was associated with greater left ventricular mass and concentric hypertrophy, particularly among individuals with diminished kidney function. Additional studies are necessary to determine the pathways that mediate this association.