tbuckley/cabot-search huggingface dataset:
PSA doubling time (PSADT) and serum testosterone (T) during intermittent androgen deprivation (IAD) in patients with biochemically relapsed prostate cancer (BRCP; M0): Potential predictive implications.
Authors: D. Keizman, P. Huang, E. S. Antonarakis, V. J. Sinibaldi, M. A. Carducci, S. R. Denmeade, M. A. Eisenberger
Journal: Journal of Clinical Oncology (2011)

150 Background: The systemic management of patients with BRPC remains controversial. IAD is commonly employed. Aims: To evaluate the PSA dynamics and serum T in pts with BRPC treated with IAD until the development of PSA refractoriness or clinical evidence of metastatic disease. Methods: Data were retrospectively analyzed in all pts with BRCP treated with GnRH at PSA thresholds according to pre-treatment PSADT (10-15ng/mL, 15-20, and 20-30 for PSADT ≤3 mos, 3-9 mos, and ≥ 9 ms, respectively) and continued until PSA nadir. Antiandrogen (AA) was added for PSA &gt; 1.0 ng/mL after 3 mos). Follow-up (FU) consisted of PSA and T q3 mos. Cycles were repeated at the above preselected PSA thresholds and continued until lack of PSA response. Scans were obtained prior to cycles and at the time of CRPC state. Mixed effects model was used to study PSADT change over cycles. Multivariate cox regression model was used to identify prognostic variables. Results: From 1995-2010, with a mean FU of 71 mos (range 22-183 months), 96 pts received a mean of 2.8 cycles (range 1-9) of IAD; 58 (60%) remain on treatment and 38 (40%) were switched to continuous ADT due to PSA refractoriness (n=11) or positive scans (n=27). PSADT at the first off treatment (tx) interval (mean 3.1, 0.59-30.5 range, median 2.3) was significantly shorter than the baseline (p&lt;0.0001; mean 9.7, range 0.27-53.9, median 7.34) but remained relatively stable (p=0.29) in subsequent cycles. PSADT adjusted for T recovery (≥3 ms after T recovery to ≥ 150 ng/dL) was significantly longer (p=0.006) than that based only on all PSA determinations (mean 5.4, range 1.31-30.5, median 3.7 versus mean 3.1, range 0.59-30.5, median 2.3). Significant factors associated with probability of PSA refractoriness were pre-IAD PSADT (≥ 6 vs &lt;6 ms), first off tx interval PSADT (≥3 ms vs &lt;3m), the use of AA during first tx cycle, and PSA nadir during the first tx interval (&lt;0.1 vs ≥0.1 ng/mL). Conclusions: Our data suggest that PSADT becomes shorter after the initial cycle of IAD and correlate with T recovery. PSA dynamics and need for AA to enhance PSA nadir are associated with PSA refractoriness in pts BRPC treated with IAD. No significant financial relationships to disclose.
Assaults on doctors.
Journal: BMJ (1978)

Assaults on doctorsThe popular stereotype of the doctor cultivated by the mass media is a composite of wisdom, equanimity-and in- vulnerability.The picture is complete only when framed in a white coat, and it may be this garment which, in some magical way, is thought to render its wearer immune from attack.In real life, however, medicine is a high-risk profession.Within the past two years in Britain a general practitioner has been killed and two consultants, one a psychiatrist and the other a general physician, gravely injured by mentally disturbed patients.In all three cases the assailants were paranoid schizophrenics who had harboured delusions-against specific doctors in two cases and against doctors in general in the third.Doctors may be increasingly exposed to danger as a result of the more liberal discharge policies from mental hospitals; the lack of community care facilities after discharge; and a growing reluctance among social workers and psychiatrists to use compulsory orders to admit violent, or potentially violent, patients to hospital.Violence may occur symptomatically in virtually every variety of mental disorder.Sudden outbursts of unprovoked, unpredictable, and inexplicable violence may arise in catatonic schizophrenia.Conversely, in paranoid schizophrenia, the cold, calculated assault may be the result of years of growing resentment of some imaginary wrong.In mania assaults may be provoked by any attempt to prevent the patient doing whatever he feels called upon to do, no matter how fatuous or dangerous that may be.Though far more a danger to themselves, victims of depression may occasionally turn on others.Hysterics in the process of acting-out may hurt themselves or those who attempt to restrain them.Those suffering from dementia are disinhibited and may become cantankerous and verbally, if not physically, aggressive.Lastly, the casual, callous violence of which the psychopath can be guilty was shown only too clearly in the murderous escape of two prisoners from Carstairs Hospital.1 2By no means all the physical hazards stem from the mentally disordered.The brain is exquisitely sensitive to any alterations in the checks and balances that keep it finely tuned, and aggressive behaviour may result from toxic-confusional states such as the delirium seen in febrile illnesses; chemical in- toxication, particularly by alcohol; drug intolerance, especially in old people whose sensitivity to even minor psychotropic drugs is well known; epilepsy; and brain damage, no matter how caused.
Korean Birds
Authors: Elspeth Cameron Ritchie
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pathology and Laboratory Medicine
Authors: Robert L. Reddick
Journal: JAMA (1992)

In the last year, the development and use of new methods to improve diagnostic acumen in anatomic pathology have continued to be major endeavors. One of the most exciting new techniques is the polymerase chain reaction (PCR). This technology allows the synthesis of multiple copies of DNA from extremely small starting samples of DNA or RNA. Polymerase chain reaction has been performed on single cells, blood spots, embryos, and tissues embedded in paraffin blocks.<sup>1</sup>In diagnostic pathology, PCR has been used to document the presence of Epstein-Barr virus sequences in Hodgkin's disease<sup>2</sup>; to study lineage and clonality in lymphomas<sup>3</sup>and gene rearrangements in B- and T-lymphoproliferative disorders<sup>4</sup>; and to detect human T-cell leukemialymphoma viruses.<sup>5</sup>The PCR technology performed on the DNA extracted from chorionic villi has been used for the prenatal diagnosis of genetic diseases, such as cystic fibrosis and β-thalassemia.<sup>6</sup>Such an approach
COORDINATION IN PUBLIC HEALTH WORK
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Enhanced apoptosis relates to bile duct loss in primary biliary cirrhosis
Authors: K Harada
Journal: Hepatology (1997)

Primary biliary cirrhosis (PBC) is characterized by an immune-mediated destruction of intrahepatic small bile ducts. Apoptosis, a unique pattern of cell death, has been suggested to be responsible for the biliary destruction in PBC. To address this issue, we attempted to detect the apoptosis of biliary epithelial cells by in situ nick-end labeling and by the expression of apoptosis-related proteins using immunohistochemistry in patients with various hepatobiliary diseases, including PBC. The data was noteworthy for several reasons. First, apoptosis was occasionally detected on biliary cells in all liver specimens; however, the positive rate was high in PBC and relatively low in other livers. Strong expression of CD95 was frequently observed in the epithelial cells of the injured bile ducts of PBC, which accompanied high intensity CD95 ligand-expressing mononuclear cells. Perforin and granzyme B immunoreactivities were occasionally found on the bile ducts in control liver diseases as well as PBC, but granzyme B-positive biliary cells were prominent in PBC. In contrast, Lewis Y expression, as detected using BM-1 antibody, was consistently present in the injured bile ducts of PBC. These data suggest that apoptosis, via the perforin/granzyme B pathway, may be associated with the degrading fraction of cell cycle regulation in the small-sized biliary tree under physiological and pathological liver conditions. Moreover, enhanced apoptosis, mediated by CD95/CD95 ligand interaction, may contribute to the bile duct injury and loss observed in PBC.
The Search for a Cause Of the Body's Cyclic Rhythms
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Recurrent amebic abscess of the liver
Authors: S. G. Jenkinson
Journal: JAMA (1975)

WITH modern chemotherapy, the mortality rate for amebic abscess of the liver is low. Complete recovery without permanent functional or anatomical abnormality is the rule.<sup>1</sup> We have had experience with a patient who had an amebic abscess of the liver in 1967, 1968, and 1972. Such recurrence or reinfection of the liver after proper chemotherapy is unusual.<sup>2</sup> <h3>Report of a Case</h3> A 34-year-old man was admitted in March 1967 because of intermittent fever (to 38 C [100 F]) for one month and a 5-kg (10-lb) weight loss. For several days there had been cough, dyspnea, and right pleuritic chest pain. Pedal edema developed one week before admission. There were physical signs of a right pleural effusion and the liver was enlarged to the level of the umbilicus. A right thoracentesis on the day of admission yielded 250 ml of bloody fluid and a pleural biopsy specimen showed necrotic
Inhibition of B-Cell Receptor Signaling Disrupts Cell Adhesion in Mantle Cell Lymphoma Via RAC2
Authors: Weige Wang, Franzen Carrie, Hui Guo, Jimmy Lee, Yan Li, Madina Sukhanova, Dong Sheng, Girish Venkataraman, Ming Mei, Pin Lu, Anhui Gao, Chunmei Xia, Li Jia, Liang Zhang, Michael Wang, Jorge Andrade, Zhou Xiaoyan, Y. Lynn Lynn Wang
Journal: Blood (2018)
Outcomes in Patients With Prolonged PR Interval or First-Degree Atrioventricular Block—Reply
Authors: Susan Cheng, Thomas J. Wang
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Computer-based and computer-planned continuing medical education for the future
Authors: J. G. Miller
Journal: JAMA (1968)

In view of the vast amount of information presently flowing from medical centers and laboratories around the world today, we face an almost insurmountable task in even defining the dimensions of the problem of providing continuing firm communications to professionals in the health disciplines. The new information-processing technologies offer promise of helping to solve the problem. It is my intention here to outline some new approaches to lifetime education in the health sciences, with use of these technologies which deserve serious consideration. When Ward Darley, MD, was executive director of the Association of American Medical Colleges, he saw clearly that recent developments in computers, television, networks, and other new information-processing media might enable continuing education.in the health fields to progress more rapidly and effectively. This interest, developed when few other medical educators had a vision of this potential, led him to bring together a small group of medical educators, particularly
SLEEPING SICKNESS.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Wife
Authors: Bonnie Salomon
Journal: Annals of Internal Medicine (2002)

Ad Libitum3 September 2002The WifeBonnie Salomon, MDBonnie Salomon, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-137-12-200212170-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The burden of the man is gone.His wife is here to pick him up.Another night, another dawn she scours local ERsTo find him here, loaded with charm,Flirting with nurses half his age.Release forms flutter in her hands.She cannot bear the doctor's gaze.He sways like a boat with gin-soaked sails.She trails in his wake.Til we meet again, he waves.The doctor advises: observation … admission.She's observed enough. He admits nothing.His bed now vacant, a new shift on duty.All are pleased at his departure.Her head bowed, eyes fixed on the floor,Car keys wrapped in knuckles so whiteThey just might crack another night. Author, Article, and Disclosure InformationAffiliations: Corresponding Author: Bonnie Salomon, MD, 53 Crestview Drive, Deerfield, IL 60015.Congratulations to Bonnie Salomon, MD, winner of the 2001 Annals Poetry Prize. Dr. Salomon's poem was published in the 3 April 2001 issue of Annals (vol. 134, no. 7) and is reprinted here. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 3 September 2002Volume 137, Issue 5_Part_1Page: 360KeywordsInterleukins ePublished: 3 September 2002 Issue Published: 3 September 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Trial halted as sickle cell treatment proves itself
Authors: C. Marwick
Journal: JAMA (1995)

THE FIRST EFFECTIVE treatment for reducing the frequency of the painful crises caused by sickle cell anemia has just been tested and pronounced helpful. This is the finding from a double-blind placebo-controlled study of the use of hydroxyurea in sickle cell disease. The study was begun by the National Heart, Lung, and Blood Institute, part of the National Institutes of Health (NIH), Bethesda, Md, in January 1992 and planned to run until May of this year. However, the results were so compelling that the study was stopped in January, said Claude Lenfant, MD, the institute's director. Daily administration of hydroxyurea reduced by approximately 50% the frequency of painful episodes and hospital admissions for the condition as well as the acute chest syndrome that is "a life-threatening complication of sickle cell anemia characterized by chest pain, fever, and an abnormal chest X-ray," said Samuel Charache, MD, Johns Hopkins University School of
Council on Physical Therapy
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Meetings and Announcements
Authors: Arthur Lim, Jodi Smith, Dar- Wan Purba, M Marsetio, R Azad, Rajendra Prasad, Yasuo Ohta, K Miyake, Jeanne Coughlin, Sindi Sonnier, David Miller, Francine Leinhardt, Mary Martino, Kathleen Melancon
Journal: Ophthalmology (1990)
Can Congenital Malformations be Prevented?
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Section 40.—Behçet's Syndrome
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal