tbuckley/cabot-search huggingface dataset:
SOFTWARE
Authors: Robert K. Naviaux
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
La sierodiagnosi della sifilide: Dottrina tecnica e valore pratico con speciale riguardo alla clinica medica. I.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reply
Authors: F J G M Kubben, A Peeters-Haesevoets, L G J B Engels, C G M I Baeten, B Schutte, J W Arends, R W Stockbrugger, G H Blijham
Journal: Gut (1995)

IFNs are a family of cytokines that are involved in the regulation of immune and inflammatory responses. Clinical use of IFN-α/β encompasses treatment for a variety of diseases; however, prolonged exposure to IFN-α/β results in elevated levels of autoreactive Abs. In this study, we investigated the potential of IFNs to modulate apoptotic signals in B cells. We demonstrate that IFN-α or IFN-β inhibit Ag receptor-mediated apoptosis in a dose-dependent manner. Inhibition of phosphatidylinositol 3′ (PI3)-kinase did not abolish the effect of IFN, indicating that the antiapoptotic mechanism is PI3-kinase- and protein kinase B/Akt-independent. Instead, IFN-α and IFN-β, but not IFN-γ, significantly increase the levels of the survival protein Bcl-2, and to a lesser extent, Bcl-x<sub>L</sub> expression. Thus, IFN-α/β-mediated inhibition of B cell Ag receptor-triggered apoptosis may offer a model for the process that leads to the escape of self-reactive B cells from negative selection and consequently results in autoantibody production.
Necrotizing Enterocolitis
Authors: Marion C.W. Henry, R. Lawrence Moss
Journal: Annual Review of Medicine (2008)

Necrotizing enterocolitis (NEC) remains a major cause of neonatal morbidity and death. The pathophysiology is poorly understood. Prevailing evidence suggests that NEC is due to an inappropriate inflammatory response of the immature gut to some undefined insult. The mortality rate (15%-25%) for affected infants has not changed appreciably in 30 years. Many infants with NEC recover uneventfully with medical therapy and have long-term outcomes similar to unaffected infants of matched gestational age. Infants with progressive disease requiring surgical intervention suffer almost all of the mortality and morbidity. Of these, approximately 30%-40% will die of their disease and most of the remainder will develop long-term neurodevelopmental and gastrointestinal morbidity. Recent randomized trials suggest that the choice of operation does not influence patient outcome. Current work is focusing on developing a better understanding of the pathogenesis and improving means to identify which infants are at greatest risk of disease progression.
0.75 mg, Not 75 mg
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Is there a role for traditional Chinese medicine?
Authors: K. K. Hui
Journal: JAMA (1997)

<h3>To the Editor.</h3> —While I agree that there are many inappropriate claims being made for many therapies in traditional Chinese medicine (TCM) and conventional Western medicine in and out of China, we should be wary of passing judgment on other systems of healing, eg, TCM, with limited knowledge and little or no experience in the medical tradition we are trying to evaluate. We must be critical; at the same time, we should always be open-minded, especially when considering world views different from our own. Traditional Chinese medicine is, for those who have mastered it, a medical paradigm complete with theoretical foundations derived from empirical observations and creative synthesis. The assertion that Mao and the Communist Party promoted barefoot doctors and traditional healers over Westerntrained physicians because of prevailing socioeconomic conditions at the time cannot be denied. However, Drs Sampson and Beyerstein<sup>1</sup>are incorrect in claiming that "the Communist Party
RSR' pattern without the evidence of bundle branch block: Diagnostic value as a sign of left ventricular aneurysm Mithilesh K. Das, Kuruvilla Cheriparambil, Majesh Makan, John Kassotis, Barry Saul, Chatla C. V. R. Reddy. Cornell University Medical College, New York, New York Methodist Hospital, Brooklyn, NY
Journal: Journal of the American College of Cardiology (2001)
Fecal Impaction
Authors: Jane F. Desforges, Keith Wrenn
Journal: New England Journal of Medicine (1989)

IN a society conscious of its bowels, enduring a fecal impaction and its treatment may be a severe humiliation. Impactions can occur in any age group, but in certain groups — especially incapacitated or institutionalized elderly people — the disorder is not only common but commonly overlooked.1 2 3 In one year-long study, 42 percent of the patients admitted to geriatric wards had a fecal impaction.4 Humiliation, however, is less important than the substantial morbidity and cost of this largely preventable problem.2 , 4 , 5 PathophysiologyFecal impaction's pathophysiologic considerations are identical to those of constipation, and the colon is the primary organ involved. The . . .
Diabetes Case Management
Authors: Mayer B. Davidson
Journal: Annals of Internal Medicine (1999)

Letters18 May 1999Diabetes Case ManagementMayer B. Davidson, MDMayer B. Davidson, MDKing-Drew Medical Center; Los Angeles, CA 90059 (Davidson)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-130-10-199905180-00009 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Aubert and colleagues' article (1) and the accompanying editorial (2) prompt several observations. Our recent 3-year study compared outcomes in 98 diabetic patients enrolled in an independent practice association health maintenance organization (HMO) who were managed by nurses following algorithms and 64 diabetic patients enrolled in a group-model HMO receiving standard care (3). Baseline glycosylated hemoglobin values declined by almost 3.0 percentage points in the nurse-managed group and nonsignificantly increased in the group-model HMO group. Total cholesterol levels greater than 240 mg/dL at baseline decreased significantly in the nurse-managed group but were unchanged in the other group.... References1. Aubert RE, Herman WH, Waters J, Moore W, Sutton D, Peterson BL, et al . Nurse case management to improve glycemic control in diabetic patients in a health maintenance organization. A randomized, controlled trial. Ann Intern Med. 1998;129:605-12. LinkGoogle Scholar2. Wagner EH. More than a case manager [Editorial]. Ann Intern Med. 1998;129:654-6. LinkGoogle Scholar3. Peters AL, Davidson MB. Application of a diabetes managed care program. The feasibility of using nurses and a computer system to provide effective care. Diabetes Care. 1998;21:1037-43. CrossrefMedlineGoogle Scholar4. Greenfield S, Rogers W, Mangotich M, Carney MF, Tarlow AR. Outcomes of patients with hypertension and non–insulin-dependent diabetes mellitus treated by different systems. JAMA. 1995;274:1436-44. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Mayer B. Davidson, MDAffiliations: King-Drew Medical Center; Los Angeles, CA 90059 (Davidson) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoNurse Case Management To Improve Glycemic Control in Diabetic Patients in a Health Maintenance Organization Ronald E. Aubert , William H. Herman , Janice Waters , William Moore , David Sutton , Bercedis L. Peterson , Cathy M. Bailey , and Jeffrey P. Koplan Diabetes Case Management Robert F. DeBusk , Nancy Houston Miller , and Jeffrey A. West Diabetes Case Management Ronald E. Aubert , Janice Waters , and William H. Herman Diabetes Case Management Anne Nettles Metrics 18 May 1999Volume 130, Issue 10Page: 862KeywordsAlgorithmsCholesterolHealth maintenance organizationsHemoglobinNursesPrimary care physiciansTreatment guidelinesUlcers ePublished: 15 August 2000 Issue Published: 18 May 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Immunohistochemical localization of the Ca<sup>2+</sup>binding S100 proteins in normal human skin and melanocytic lesions
Authors: R. BÖNI, G. BURG, A. DOGUOGLU, E.C. ILG, B.W. SCHÄFER, B. MÜLLER, C.W. HEIZMANN
Journal: British Journal of Dermatology (1997)
Bevacizumab (Bev) with or without erlotinib as maintenance therapy, following induction first-line chemotherapy plus Bev, in patients with metastatic colorectal cancer (mCRC): Efficacy and safety results of the international GERCOR DREAM phase III trial.
Authors: Christophe Tournigand, Benoit Samson, Werner Scheithauer, Gérard Lledo, Frédéric Viret, Thierry Andre, Jean François Ramée, Nicole Tubiana-Mathieu, Jérôme Dauba, Olivier Dupuis, Yves Rinaldi, May Mabro, Nathalie Aucoin, Ahmed Khalil, Jean Latreille, Christophe Louvet, David Brusquant, Franck Bonnetain, Benoist Chibaudel, Aimery De Gramont
Journal: Journal of Clinical Oncology (2012)

LBA3500^ The full, final text of this abstract will be available at abstract.asco.org at 12:01 AM (EDT) on Sunday, June 3, 2012, and in the Annual Meeting Proceedings online supplement to the June 20, 2012, issue of Journal of Clinical Oncology. Onsite at the Meeting, this abstract will be printed in the Sunday edition of ASCO Daily News.
Sex and Drugs in Popular Movies: An Analysis of the top 200 Films
Authors: Hasantha Gunasekera, Simon Chapman, Sharon Campbell
Journal: Journal of the Royal Society of Medicine (2005)

We analyse the portrayal of sex and drug use in the most popular movies of the last 20 years using the Internet Movie Database list of the top 200 movies of all time. Films released or set prior to the HIV era (pre 1983), animated, not about humans or G/PG rated, were excluded. Films were reviewed by one of two teams of two observers using a data extraction sheet tested for inter-rater reliability. Sexual activity, sexually transmitted disease (STD) prevention, birth control measures, drug use and any consequences discussed or depicted were recorded. There were 53 sex episodes in 28 (32%) of the 87 movies reviewed. There was only one suggestion of condom use, which was the only reference to any form of birth control. There were no depictions of important consequences of unprotected sex such as unwanted pregnancies, HIV or other STDs. Movies with cannabis (8%) and other non-injected illicit drugs (7%) were less common than those with alcohol intoxication (32%) and tobacco use (68%) but tended to portray their use positively and without negative consequences. There were no episodes of injected drug use. Sex depictions in popular movies of the last two decades lacked safe sex messages. Drug use, though infrequent, tended to be depicted positively. The social norm being presented is concerning given the HIV and illicit drug pandemics.
DEFICIENCY OF THE FIFTH COMPONENT OF COMPLEMENT IN MICE WITH AN INHERITED COMPLEMENT DEFECT
Authors: Ulf R. Nilsson, Hans J. Müller-Eberhard
Journal: The Journal of Experimental Medicine (1967)

The inherited complement deficiency of certain inbred strains of mice was shown to be due to an isolated lack of the fifth component of complement. The protein MuB1 (or hc'), which is present in normal mouse serum but absent from the serum of complement-deficient mice, was shown to be immunochemically related to the fifth component of human complement (C'5). C'5 hemolytic activity was specifically inhibited in human serum by mouse anti-MuB1 and in normal mouse serum by mouse antiserum to human C'5. Highly purified human C'5 reconstituted the hemolytic activity of complement-deficient mouse serum. It was, therefore, concluded that he', or MuB1, constitutes the murine analogue of the fifth component of human complement. The MuB1 concentration in normal mouse serum was found to be subject to a sex-related variation. By quantitative precipitin analysis it was demonstrated that serum from male mice contains twice as much MuB1 as that of female mice. This difference in C'5 concentration was also detected by hemolytic assay. In addition, C'6 and C'7 were also found to be subject to sex-related variations.
Quantitative analysis of antibodies to hepatitis C virus during interferon-α therapy
Authors: N Yuki
Journal: Hepatology (1993)

We quantified IgG antibodies to structural (core) and nonstructural (C100-3) hepatitis C virus proteins in 42 patients with chronic hepatitis C treated with a 6-mo course of interferon-α Sera were drawn before and at the end of therapy and also 6 mo after therapy withdrawal; they were stored for later analysis of antibodies and serum hepatitis C virus RNA. Sustained virus clearance was observed at the end of therapy and 6 mo after therapy withdrawal in nine cases; it was accompanied with sustained reductions of antibody to hepatitis C virus core protein and antibody to C 100-3 protein. A sustained reduction of antibody to hepatitis C virus core protein was specific to sustained virus clearance, although that of antibody to C 100-3 protein was not. None of the patients who did not show reductions of levels of both antibodies at the end of therapy displayed sustained virus clearance. Five patients showed hepatitis C virus RNA negativity and normal aminotransferase levels at the end of therapy without reduction of antibody to hepatitis C virus core protein levels. Of these five patients, relapse of hepatitis occurred in four, and viremia was present 6 mo after therapy withdrawal in all cases. These results demonstrate that testing for antibody titers may add information for evaluating virus clearance after interferon therapy. (HEPATOLOGY 1993;17:960–965.)
CURRENT LITERATURE.
Journal: British Journal of Dermatology (1958)

British Journal of DermatologyVolume 70, Issue 1 p. 35-36 CURRENT LITERATURE. First published: January 1958 https://doi.org/10.1111/j.1365-2133.1958.tb13791.xAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Volume70, Issue1January 1958Pages 35-36 RelatedInformation
Phase II capecitabine and gemcitabine fixed dose rate (FDR) in patients with advanced pancreatic cancer
Authors: D. Santini, B. Vincenzi, G. Masi, V. Catalano, V. Virzi, A. Fontana, E. Vasile, S. Intagliata, G. Catalano, A. Falcone, G. Tonini
Journal: Journal of Clinical Oncology (2008)

15596 Background: Although Gemcitabine remains the standard of care for patients with advanced pancreatic cancer, additional improvements may be realized by optimizing drug delivery using pharmacokinetic principles such as fixed dose rate (FDR) infusion. The aims of this phase II trial are to determine the activity and the safety of the combination of Gemcitabine FDR and Capecitabine in patients with advanced pancreatic cancer. Methods: Patients with unresectable pancreatic cancer who had pathologically confirmed adenocarcinoma, no prior chemotherapy, ECOG PS < 2 and measurable disease were enrolled. Gemcitabine (800 mg/mq IV infused in 80 minutes on days 1 and 8) and Capecitabine (650 mg/mq orally twice daily for 14 days) were administered and repeated every 21 days. Results: 25 patients were enrolled between January 2004 and May 2007. Median age was 66 (range: 37–79), 10 female and 15 male. 24/25 patients were evaluable for response and toxicity. A total of 161 cycles were administered, median cycles for patient were 6 (range: 2–17). CR was observed in one patient (4.0 %) and 5 patients achieved PR (20.0 %) giving an overall response rate of 24.0 % in intention-to-treat population. 11 pts (44.0 %) had stable disease obtaining an overall tumour control of 68.0 %. The median time to progression was 5.0 months (95 % CI, 2.4–7.6); the median overall survival was 8.0 months (95 % CI, 5.5–10.4). Grade 3–4 neutropenia was observed in 32.0 % of subjects, thrombocytopenia in 12.0 %. Grade 1–2 non-hematological toxicities were asthenia (60.0 %), diarrhea (32.0 %), stomatitis (28.0 %) and HFS (4.0 %). There were no treatment-related deaths. Gemcitabine was skipped at least once/reduced in 32/12 % of the patients, respectively. Capecitabine was skipped at least once/reduced in 16/8 % of the patients, respectively). Conclusions: The combination of FDR Gemcitabine and Capecitabine in this combination is feaseble, safe and seems to be active. No significant financial relationships to disclose.
Bull of Gastrointestinal Endoscopy, Denver
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Traduttore, Traditore
Authors: Wm. MacMillan Rodney
Journal: JAMA (1986)

<h3>To the Editor.—</h3> Since I have taught and practiced in cross-cultural environments over the past ten years, the recent article by Dr Putsch<sup>1</sup>had special significance for me. My colleagues and I are family physicians and our experiences have been similar to those described.<sup>2,3</sup> There are special issues regarding the care of Spanish-speaking patients that remain unaddressed. We have previously documented the underdiagnosis of psychosocial issues in a family medicine setting.<sup>4</sup>An interesting finding was the large percentage of patients who spoke Spanish only. We applied multivariate techniques to discern possible etiologies for "noshow" behavior by family medicine patients.<sup>5</sup>This analysis selected language barrier as an important issue. These experiences and studies led us to slightly different conclusions regarding general guidelines for monolingual providers. First of all, we borrowed from Osler's dictum that "who the patient is is more important than what disease the patient has." Therefore,