tbuckley/cabot-search huggingface dataset:
Counseling, Assurance, Self-Care Valuable to Colostomy Patient
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Continuous Venous Pressure Monitoring as a Guide to Fluid Administration in the Hypotensive Patient
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Acute epiglottitis in adults. Analysis of 129 cases
Authors: T. D. Frantz
Journal: JAMA (1994)

<h3>Objective.</h3> —To characterize the clinical features of acute epiglottitis in adults and to identify factors associated with airway intervention. <h3>Design.</h3> —Case series. <h3>Setting.</h3> —Northern California health maintenance organization. <h3>Participants.</h3> —A total of 129 patients aged 18 years or older with laryngoscopically confirmed acute epiglottitis admitted from November 1986 through October 1991. <h3>Results.</h3> —The mean patient age was 47 years (range, 18 to 85 years) and the male-to-female ratio was 1.8 to 1.0 (<i>P</i>&lt;.001). The most common symptoms were sore throat (95%) and odynophagia (94%); the most common signs were muffled voice and evidence of pharyngitis. Nineteen patients (15%) received airway intervention, including seven with tracheotomy and 12 with endotracheal intubation. The remaining 110 patients recovered fully without airway intervention. In multivariate analysis, factors associated with airway intervention were stridor (relative risk [RR], 6.2; 95% confidence interval [CI], 1.7 to 22.9) and sitting erect (RR, 4.8; 95% CI, 1.3 to 16.1). Six (12%) of 52 blood cultures yielded<i>Haemophilus influenzae</i>type b. Major complications occurred in six patients (5%), but no deaths occurred. <h3>Conclusion.</h3> —Most adults who have acute epiglottitis can be managed conservatively and have low morbidity and mortality. (<i>JAMA</i>. 1994;272:1358-1360)
THE CALIFORNIA CATACLYSM; AN APPEAL.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cytogenetic Studies in Human Populations Exposed to Gas Leak at Bhopal, India
Authors: Bani Bandana Ghosh, Susmita Sengupta, Ajoy Roy, Srabani Maity, Sujita Ghosh, Geeta Talukder, Archana Sharma
Journal: Environmental Health Perspectives (1990)

Frequencies of chromosomal abnormalities, sister chromatid exchanges, and replicative index were assessed following peripheral lymphocyte culture in 129 individuals from Bhopal, India. Of these, 83 persons (40 male and 43 female) had been exposed directly to the methyl isocyanate (MIC) gas after the accident at the Union Carbide plant on December 2 and 3, 1984. The remaining 46 samples were taken from age-matched unexposed persons in the same city. Chromosome aberrations were recorded at first cycle metaphase (M1) and sister chromatid exchanges, at second cycle metaphase (M2), following standard schedule. The frequency of chromosomal aberrations was, in general, higher in individuals from the exposed populations, with the females showing a higher incidence. Nondisjunction of chromosomes or laggard was rare. The frequencies of sister chromatid exchanges and depression in mitotic and replicative indices could not be related to exposure or sex. The persistence of chromosomal abnormalities in the form of replicating minutes and exchange configurations, even 1114 days after exposure to the gas, may indicate a residual effect on T-cell precursors.
Clinical Biostatistics
Authors: William R. Best
Journal: JAMA (1978)

Which of today's clinical "pearls" are truly gems, and which are made of paste? Many standard therapies of yesteryear are now considered humorous at best. Feinstein, as a clinician, mathematician, and statistician (or antistatistician, according to some) is a searcher for the truth and applies his critical eye to the methods investigators use today to collect data and from them make inferences about various problems in clinical medicine. Since 1970 he has been responsible for a series of essays entitled "Clinical Biostatistics," which have appeared in the journal<i>Clinical Pharmacology and Therapeutics</i>. Twenty-nine of about 40 such essays form the substance of this book. This collection should be of interest to clinicians and statisticians with similar concerns. At least a rudimentary knowledge of statistics is assumed. The true clinical experiment, prospective survey, and retrospective survey are clearly differentiated. Problems in the design and interpretation of surveys, when true experiments are
The Pomelo, or Grapefruit
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The tricyclic antidepressants
Authors: N. R. Cutler
Journal: JAMA (1978)

Because only 9.4% of depressions are recognized at initial evaluation by primary physicians, the diagnosis of depression is important. Forty percent of a group of mixed depressions will resolve in a month without treatment, and 70% will resolve with the use of tricyclic antidepressants. Research on plasma levels of tricyclic antidepressants suggests new clinical strategies for adjusting dosages; neurochemical studies may provide an appropriate selection process for choosing a tricyclic antidepressant. (<i>JAMA</i>240:2264-2266, 1978)
AASLD/alpha-1 antitrypsin symposium
Journal: Hepatology (2003)

Progression of osteoarthritis in the unreplaced compartment following unicondylar knee arthroplasty (UKA) may be hastened if kinematics is disturbed following UKA implantation. The purpose of this study was to analyze tibiofemoral kinematics of the balanced and overstuffed UKA in comparison with the native knee during passive flexion since this is a common clinical assessment.Ten cadaveric knees were mounted to robotic manipulator and underwent passive flexion from 0 to 90°. The kinematic pathway was recorded in the native knee and in the balanced, fixed bearing UKA. The medial UKA was implanted using a measured resection technique. Additionally, a one millimeter thicker tibial insert was installed to simulate the effects of overstuffing. Tibial kinematics in relation to the femur was recorded.Following UKA the tibia was externally rotated, and in valgus relative to the native knee near extension. In flexion, installing the UKA caused the knee to be translated medially and anteriorly. The tibia was translated distally through the entire range of flexion after UKA. Compared to the balanced UKA, overstuffing further increased valgus at full extension and distal translation of the tibia from full extension to 45° flexion.UKA implantation altered tibiofemoral kinematics in all planes. Differences were small; nevertheless, they may affect tibiofemoral loading patterns.Alterations in tibiofemoral kinematics following UKA might have implications for prosthesis failure and progression of osteoarthritis in the remaining compartment. Overstuffing should be avoided as it further increased valgus and did not improve the remaining kinematics.
Parallel 5: Experimental Hepatocarcinogenesis
Authors: François Cauchy, Mouniya Mebarki, Pierre Bourgoin, Cindy Neuzillet, Samira Laouirem, Miguel Albuquerque, Nicolas Poté, Jacques Belghiti, Eric Raymond, Pierre Bedossa, Val- Erie Paradis, Kan Toriguchi, Eiichiro Nishi, Etsuro Hatano, Kazutaka Tanabe, Kenji Takemoto, Satoru Seo, Kojiro Taura, Shinji Uemoto
Journal: Hepatology (2014)
Social security and the physician
Authors: C. P. Hall
Journal: JAMA (1965)

One of the major objectives of most modern "social insurance" programs is universality of coverage; yet self-employed American physicians were able to maintain their independence from the federal Old-Age, Survivors' and Disability Insurance program for almost 30 years. The sweeping amendments to the Social Security Act which were signed into law on July 30, however, ended the era of the self-employed physician's nonparticipation. All physicians now will be liable for OASDI taxes for the taxable year ending Dec 31, 1965, and thereafter. The first tax payment by self-employed physicians will be due on or before April 15, 1966. Benefits will be available to this group, depending on eligibility discussed below. <h3>Taxes</h3> What changes are in store? The most obvious one will be that nearly all physicians will immediately begin paying Social Security taxes at the maximum level, since few, if any, earn less than $6,600 annually. Though many physicians on
Breast-feeding
Authors: L. Goldstone
Journal: BMJ (1958)

<b>BACKGROUND AND PURPOSE:</b> MR imaging features of metronidazole-induced encephalopathy (MIE) have not been fully established. This study was undertaken to determine the topographic distributions and diffusion-weighted imaging (DWI) findings of MIE. <b>MATERIALS AND METHODS:</b> We retrospectively evaluated the initial MR images (<i>n</i> = 7), including DWI (<i>n</i> = 5), and follow-up MR images (<i>n</i> = 4) after drug discontinuation in 7 patents with clinically diagnosed MIE. The topographic distributions of lesions were evaluated on MR images, and DWI signal intensities and apparent diffusion coefficient (ADC) values of the lesions were assessed. <b>RESULTS:</b> MR images demonstrated bilateral symmetric T2 hyperintense lesions in the cerebellar dentate nucleus (<i>n</i> = 7), midbrain (<i>n</i> = 7), dorsal pons (<i>n</i> = 6), medulla (<i>n</i> = 4), corpus callosum (<i>n</i> = 4), and cerebral white matter (<i>n</i> = 1). Brain stem lesions involved the following: tectum (<i>n</i> = 5), tegmentum (<i>n</i> = 4), red nucleus (<i>n</i> = 3) of the midbrain, vestibular nucleus (<i>n</i> = 6), and a focal tegmental lesion involving the superior olivary nucleus (<i>n</i> = 6) and abducens nucleus (<i>n</i> = 4) of the pons and vestibular nucleus (<i>n</i> = 4) and inferior olivary nucleus (<i>n</i> = 1) of the medulla. DWI (<i>n</i> = 5) showed isointensity or hyperintensity of lesions, and the decreased ADC value was found only in the corpus callosum lesions (<i>n</i> = 2). All detected lesions were completely reversible at follow-up except for the single corpus callosum lesion with an initial low ADC value. <b>CONCLUSION:</b> Brain lesions were typically located at the cerebellar dentate nucleus, midbrain, dorsal pons, medulla, and splenium of the corpus callosum. According to DWI, most of the lesions in MIE probably corresponded to areas of vasogenic edema, whereas only some of them, located in the corpus callosum, corresponded to cytotoxic edema.
Intracoronary stenting and angiographic results: Strut thickness effect on restenosis outcome (ISAR-STEREO) trial Adnan Kastrati, Julinda Mehilli, Josef Dirschinger, Franz Dotzer, Franz-Josef Neumann, Helmut Sch�hlen, Martin Fleckenstein, Conrad Pfafferott, Albert Sch�m,ig. Deutsches Herzzentrum &amp; 1. Med. Klinik rechts der Isar, Munich, Germany, Medizinische Klinik I, Garmisch-Partenkirchen, Germany
Journal: Journal of the American College of Cardiology (2001)
Michigan Tests Short-Term Anesthetic
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
'Confidentiality' issues may cloud epidemiologic studies of AIDS
Authors: C. Marwick
Journal: JAMA (1983)

Charges of breach of confidentiality have led the Centers for Disease Control (CDC) to try to develop a coding system for reports on patients with acquired immune deficiency syndrome (AIDS) so that patient names will not have to be used. "We hope this will allow us to keep tabs on individual cases," said James R. Allen, MD, of the CDC's AIDS Task Force. "It's a compromise—the best available to us under the circumstances." The CDC denies it has released confidential information to nonhealth agencies but does concede that on at least three occasions it has released lists of names of AIDS victims to local health agencies not affiliated with the federal government. In one instance, names were released to the New York Blood Center in connection with a follow-up study on whether AIDS had developed in persons who received the hepatitis B vaccine. The vaccine is made from the plasma
Systematic Review for the 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines
Authors: David M. Reboussin, Norrina B. Allen, Michael E. Griswold, Eliseo Guallar, Yuling Hong, Daniel T. Lackland, Edgar (Pete) R. Miller, Tamar Polonsky, Angela M. Thompson-Paul, Suma Vupputuri
Journal: Circulation (2018)

Objective To review the literature systematically and perform meta-analyses to address these questions: 1) Is there evidence that self-measured blood pressure (BP) without other augmentation is superior to office-based measurement of BP for achieving better BP control or for preventing adverse clinical outcomes that are related to elevated BP? 2) What is the optimal target for BP lowering during antihypertensive therapy in adults? 3) In adults with hypertension, how do various antihypertensive drug classes differ in their benefits and harms compared with each other as first-line therapy? Methods Electronic literature searches were performed by Doctor Evidence, a global medical evidence software and services company, across PubMed and EMBASE from 1966 to 2015 using key words and relevant subject headings for randomized controlled trials that met eligibility criteria defined for each question. We performed analyses using traditional frequentist statistical and Bayesian approaches, including random-effects Bayesian network meta-analyses. Results Our results suggest that: 1) There is a modest but significant improvement in systolic BP in randomized controlled trials of self-measured BP versus usual care at 6 but not 12 months, and for selected patients and their providers self-measured BP may be a helpful adjunct to routine office care. 2) systolic BP lowering to a target of <130 mm Hg may reduce the risk of several important outcomes including risk of myocardial infarction, stroke, heart failure, and major cardiovascular events. No class of medications (ie, angiotensin-converting enzyme inhibitors, angiotensin-receptor blockers, calcium channel blockers, or beta blockers) was significantly better than thiazides and thiazide-like diuretics as a first-line therapy for any outcome.
Pharmacologic Aspects of Adrenocortical Steroids and ACTH in Man
Authors: George W. Thorn, Dalton Jenkins, John C. Laidlaw, Frederick C. Goetz, Joseph F. Dingman, Walter L. Arons, David H. P. Strebten, Brian H. McCracken
Journal: New England Journal of Medicine (1953)

ACTHThe classic studies of Smith469 , 470 showed that marked atrophy of the adrenal cortex followed hypophysectomy in the rat and that this change could be prevented by intramuscular implantation of rat pituitary glands. Subsequently, in 1933, four groups of investigators471 472 473 474 reported that anterior pituitary extracts could produce adrenocortical hypertrophy in animals. Since that time there has been steady progress in the preparation of highly potent pituitary fractions possessing "trophic" activity with respect to the adrenal cortex.Nature of ACTHThe adrenocorticotrophic activity of pituitary extracts has been assayed principally by three methods, the first being that based on adrenal size . . .
Type 2 Diabetes
Authors: Sandeep Vijan
Journal: Annals of Internal Medicine (2015)

Letters18 August 2015Type 2 DiabetesSandeep Vijan, MD, MSSandeep Vijan, MD, MSFrom Ann Arbor Veterans Affairs Health System, University of Michigan Medical School, Ann Arbor, Michigan.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L15-5122-2 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:I agree with Dr. Bell's comment. Thiazolidinediones do not cause hypoglycemia as monotherapy. This was misstated in the initial article; I intended to suggest that they can cause hypoglycemia in combination with other drugs (such as insulin or sulfonylureas). Weight gain is a clear adverse effect of thiazolidinediones and, as Dr. Bell notes, is largely due to fluid retention and has been associated with higher rates of congestive heart failure (1).I also agree that avoiding hypoglycemia is an important consideration when choosing treatment agents. Metformin is the clear first-choice treatment given its possible mortality benefit and generally ...Reference1. Lago RM, Singh PP, Nesto RW. Congestive heart failure and cardiovascular death in patients with prediabetes and type 2 diabetes given thiazolidinediones: a meta-analysis of randomised clinical trials. Lancet. 2007;370:1129-36. [PMID: 17905165] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Ann Arbor Veterans Affairs Health System, University of Michigan Medical School, Ann Arbor, Michigan.Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L15-0311. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoType 2 Diabetes David S.H. Bell Type 2 Diabetes David S.H. Bell Metrics Cited byBioengineered Pancreas–Liver Crosstalk in a Microfluidic Coculture Chip Identifies Human Metabolic Response Signatures in Prediabetic HyperglycemiaType 2 Diabetes Mellitus: Beyond the Beta CellText Mining for Hypotheses and Results in Translational Medicine Studies 18 August 2015Volume 163, Issue 4Page: 322KeywordsConflicts of interestDisclosureDrugsGlucoseHeart failureHypoglycemiaInsulinMortalityType 2 diabetesWeight gain ePublished: 18 August 2015 Issue Published: 18 August 2015 Copyright & PermissionsCopyright © 2015 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...