tbuckley/cabot-search huggingface dataset:
Rheumatism
Authors: Judith Skillman
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Characteristics of T-Lymphocytes Infiltrating Human B-Cell Lymphomas
Authors: Peter Marquardt, Hans Konrad Muller-Hermelink
Journal: Environmental Health Perspectives (1990)

Using a recently described technique for direct expansion of human T-lymphocytes isolated from small intestine biopsies, we have investigated the local cellular immune response in six patients with B-cell lymphomas of various subtypes. T-cell lines (TCL) were established by seeding tumor-infiltrating T-lymphocytes (T1TL) at limiting dilution in the presence of irradiated feeder cells in culture medium containing rIl-2 and phytohemagglutinin (PHA). About 1/50 T-cells gave rise to a TCL; they all were CD3+. The CD4/CD8 ratio was 3.8:1 before and after cloning. Of 45 TCLs analysed so far from one patient with B-cell lymphoma of the lung, 4 were cytotoxic as shown by their ability to exert lectin-dependent cytotoxicity against allogeneic target cells. Of these, 3 demonstrated specificity for the autologous malignant B-cells. Five TCLs lysed the NK-sensitive K562 cell line in a HLA-unrestricted manner. When tested for antigen-specific proliferative activity, 4 TCLS only responded to the autologous lymphoma cells, but 5 TCLs reacted to the autoantigenic ganglioside GM1. Southern Blot analyses did not show a clonal pattern of T-cell receptor gene rearrangement within all TITL populations. The peripheral T-lymphocytes of the lymphoma patients showed a drastically reduced response to the mitogens PHA. Concanavalin A, and pokeweed mitogen. The present report demonstrates that it is possible to analyze TITL at clonal level. This technique may be the only means of investigating the specificity of the TITL and may help us to identify the relevant tumor-associated autoantigens if tumor-induced autoimmunization is indeed one of the mechanisms that control the growth of tumors and metastases.
SODIUM CITRATE AS AN ADDITION TO MILK MIXTURES FOR NURSING INFANTS.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
American Humane Association.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Laetrile on trial
Authors: T. H. Jukes
Journal: JAMA (1979)

ON SEPT 27, 1978, Arthur Upton, MD, director of the National Cancer Institute (NCI), announced that the NCI would conduct a clinical trial of laetrile in 150 to 300 patients with terminal cancer. This COMMENTARY reviews some of the background and implications of this decision as I see them. <h3>The NCI Laetrile Review1</h3> This was a review of cases thought to have shown objective benefit from use of laetrile. The case reports were obtained by mailing requests to 385,000 physicians and 70,000 other health proponents and by direct contact with pro-laetrile groups. Only 93 cancer cases were submitted for evaluation, and 26 of these were rejected because of incomplete data. A panel (names listed in review) judged six of the remaining 67 patients to have responded (two completely and four partially). One of 24 "no treatment" control patients showed a partial response. The authors warn that "submission of incorrect
Baseline results of therapy for burned patients
Authors: I. Feller
Journal: JAMA (1976)

Baseline results of therapy for burned patients have been determined. The data (21,000 cases) from the National Burn Information Exchange have been analyzed by probit analysis to determine survival as it is influenced by the size and depth of the burn, age and sex of patients, topical agents, and the institution providing treatment. The results demonstrate that survival is influenced by the size and depth of the burn; that there is increased survival of males, compared to that of females; that five different age categories can be identified that influence survival; that the topical agent used has little effect on survival; and that there is a significant difference in survival when the institution providing the treatment is considered. (<i>JAMA</i>236:1943-1947, 1976)
Prevention of spread of hepatitis C
Authors: Miriam J. Alter
Journal: Hepatology (2002)

Hepatitis C virus (HCV) is transmitted by percutaneous or permucosal exposure to infectious blood or blood-derived body fluids. Based on the results of cohort and acute case control studies, risk factors associated with acquiring HCV infection in the United States have included transfusion of blood and blood products and transplantation of solid organs from infected donors, injecting drug use, occupational exposure to blood (primarily contaminated needle sticks), birth to an infected mother, sex with an infected partner, and multiple heterosexual partners. Nosocomial and iatrogenic transmission of HCV primarily are recognized in the context of outbreaks, and primarily have resulted from unsafe injection practices. Transmission from HCV-infected health care workers to patients is rare. Transfusions and transplants have been virtually eliminated as sources for transmission, and most (68%) newly acquired cases of hepatitis C are related to injecting drug use. The primary prevention of illegal drug injecting will eliminate the greatest risk factor for HCV infection in the United States. Other prevention strategies that need to be widely implemented include risk reduction counseling and services and review and improvement of infection control practices in all types of health care settings. Testing for HCV infection should be routinely performed for persons at high risk for infection or who require postexposure management. There are no recommendations for routine restriction of professional activities for HCV-infected health care workers, and persons should not be excluded from work, school, play, and child care or other settings on the basis of their HCV infection status. (Hepatology 2002;36:S93-S98).
Nutritional anemia in an inner-city community. Relationship to age and ethnic group
Authors: R. Katzman
Journal: JAMA (1972)

The extent of anemia was investigated in 1,789 individuals under 21 years of age residing in an inner-city neighborhood. The study group was composed of 56% black, 33% Spanish-speaking, and 11% white individuals. The results reveal that 12.5% of those 10 to 36 months of age, 4.4% of those 3 to 10 years of age, 2.4% of those 10 to 14 years of age, and 13.5% of the girls and 1.2% of the boys 14 to 21 years of age were anemic by hematocrit determination. With the use of hemoglobin determinations, a larger proportion was found to be anemic. Ethnic differences were noted among teen-age girls: white and Spanish-speaking girls were found to be anemic less frequently than black girls of the same age. The results suggest that nutrition counseling and iron supplementation, when indicated, should continue into adolescence.
<i>Announcement:</i>National Diabetes Month — November 2016
Journal: MMWR Morbidity and Mortality Weekly Report (2016)

November is National Diabetes Month. In the United States, 29 million persons have diabetes and 86 million adults have prediabetes, putting them at risk for developing type 2 diabetes, heart disease, and stroke (1). Approximately 28% of those with diabetes are undiagnosed (1), and 89% of those with prediabetes do not know they have it (2). Type 2 diabetes, which accounts for 90%-95% of all cases of diagnosed diabetes in the United States, can be prevented through lifestyle changes, such as weight loss, healthy eating, and increased physical activity (1,3). Persons with diabetes can take steps to control the disease and prevent complications (1,4).
Intraperitoneal Povidone-lodine
Authors: Paul D. Goldenheim
Journal: JAMA (1989)

<h3>To the Editor.—</h3> The remarks by Dr Roslyn<sup>1</sup>concerning intraperitoneal povidone-iodine (PVP-I) require comment. We have not sought Food and Drug Administration approval for peritoneal irrigation with PVP-I, the active component of our Betadine preparations, and its utility for this purpose remains to be defined. However, we must question portions of Dr Roslyn's response. One reason is the acknowledged difficulty in comparing results of the numerous studies that involved peritoneal lavage with PVP-I, each of which used varying methodologies. Many variables affect these results, including the way systemic antibiotics are used, the thoroughness of local cleansing, the degree of contamination, and the patient's general condition. Nevertheless, a substantial body of literature, both clinical and preclinical, supports intra-abdominal use of PVP-I at appropriate concentrations. Dr Rosyln's reference to an experimental model in which this use was associated with increased mortality concerned a study involving dogs (reference 3). Some investigators have
Impact of putative chemopreventative agents on prostate cancer diagnosis.
Authors: Hanan Goldberg, Faizan Moshin, Zachary William Abraham Klaassen, Thenappan Chandrasekar, Christopher Wallis, Jaime Omar Herrera Cáceres, Ardalan Ahmed, Teck Sing Woon, Girish S. Kulkarni, Alejandro Berlin, Refik Saskin, Robert James Hamilton, Shabbir M.H. Alibhai, Neil Eric Fleshner
Journal: Journal of Clinical Oncology (2019)

40 Background: Prostate cancer (PC) is the most common non-cutaneous cancer in Canadian men and the third most common cause of cancer death in Canada. Several studies have shown that use of commonly prescribed medications, including those used for diabetes and hypercholesterolemia, is associated with improved survival in various malignancies, including PC. There has not been any large population-based study, examining the effects of these and other commonly prescribed medications, on the rate of PC diagnosis, over a 20 years follow-up period. Methods: A retrospective population-based study using data from the institute of clinical evaluative sciences, including all male patients aged 65 and above in Ontario who have had a negative first prostate biopsy between 1994 and 2016. We assessed the impact of commonly prescribed medications on PC diagnosis. The medications included Statins (hydrophilic and hydrophobic), diabetes drugs (metformin, insulins, sulfonylureas, and thizolidinedions), proton pump inhibitors, 5 alpha reductase inhibitors, and alpha blockers. Time dependent Cox regression proportional hazards models were performed determine predictors of PC diagnosis. Medication exposure was time varying and modeled as “ever” vs. “never” use or as cumulative exposure for 6 months of usage. A priori variables included in the model included age, ADG comorbidity score, rurality index, index year, and all medications. Results: A total of 51,415 men were analyzed over a mean (SD) follow-up time of 8.06 (5.44) years. Overall, 10,466 patients (20.4%) were diagnosed with PC, 16,726 (32.5%) had died, and 1,460 (2.8%) patients died of PC. On multivariable analysis increasing age and rurality index were associated with higher PC diagnosis rate, while a more recent index year, and usage of hydrophilic statins was associated with a lower diagnosis rate in both “ever” vs. “never” and cumulative models (HR 0.832, 95% CI 0.732-0.946, p = 0.005, HR 0.973 95% CI 0.951-0.995, p = 0.016, respectively). Conclusions: Hydrophilic statins are associated with a clinically significant lower PC diagnosis. To our knowledge this is the first study demonstrating a clear advantage of one group of statins (hydrophilic) over another (hydrophobic) in PC prevention.
Plasmapheresis as a Method of Immune Modulation and Treatment in Cancer Patients
Journal: JNCI Journal of the National Cancer Institute (1979)

Journal Article Plasmapheresis as a Method of Immune Modulation and Treatment in Cancer Patients Get access JNCI: Journal of the National Cancer Institute, Volume 62, Issue 5, May 1979, Page 1319, https://doi.org/10.1093/jnci/62.5.1319-d Published: 01 May 1979
Intestinal parasites in Southeast-Asian refugees. Prevalence in a community of Laotians
Authors: A. M. Wiesenthal
Journal: JAMA (1980)

In response to public concerns, 165 Meo Laotians had stools screened for intestinal parasites by the Illinois Department of Public Health. One hundred twenty-nine had at least one pathogenic parasite detected. Hookworm was detected most frequently, followed by<i>Giardia lamblia, Trichuris trichiura</i>, and<i>Ascaris lumbricoides</i>. Hookworm and overall infection were more frequent in persons 4 years of age and older, while giardiasis, ascariasis, and trichuriasis were most common in the 4- to 14-year age group. Most infections were helminthic and of no public health consequence in the United States. However, giardiasis was seven times as prevalent in refugee children as in the general US population, posing a potential public health risk in child-care settings. (<i>JAMA</i>1980;244:2543-2544)
Influence of geriatric consultation with Comprehensive Geriatric Assessment (CGA) on therapeutic decision in elderly cancer patients
Authors: P. Chaïbi, S. Breton, C. Tresallet, L. Hannoun, F. Piette, C. Jasmin, D. Khayat, G. Auclerc, J. Spano
Journal: Journal of Clinical Oncology (2008)

9581 Background: Elderly patients represent an heterogeneous population in which anticancer therapeutic decision is often difficult. CGA has been described as useful for therapeutic decision in elderly cancer patients. We report one year activity of the geriatric assessment consultation of our institution, and its impact on final therapeutic decision. Methods: Since January 2007, we propose a geriatric consultation for elderly cancer patients for whom therapeutic decision appears complex to oncologists. This consultation included a CGA, with focuses on items like comorbidity, dependence, cognitive impairment, depression and malnutrition using international well known scales. Results: In 2007, 76 elderly patients (25 men, 51 women) (median age 82 years, extremes 73 -94) were seen at the geriatric consultation. Most of the patients (65/76) were in fist line treatment for colorectal (25), other digestive (19), breast (10) and pulmonary (6) cancers. Cancer was metastatic in 36 patients (47 %). Geriatric assessment found severe comorbidity (grade 3 or 4 in CIRS-G scale) in 24 patients; dependence for at least one activity of daily living (ADL) in 16 patients; cognitive impairment in 19 patients, including 8 patients with already diagnosed Alzheimer disease; malnutrition in 46 patients (60 %); depression in 22 patients. According to prior oncologist decision, there have been no change in therapeutic decision in 16 patients only. Geriatric interventional treatment was delivered to 55 patients (72 %). Anticancer treatment was changed in 36 patients (47 %), including delayed therapy in 4 patients, less intensive therapy in 15 patients and more intensive therapy in 17 patients. Patients for whom final decision was delayed or less intensive therapy had significantly more frequent severe comorbidity (13/19, p < 0.01), dependence for at least one ADL (8/19, p < 0.01) and cognitive impairment (9/19, p < 0.05).Patients for whom final decision was more intensive therapy had significantly more frequent metastatic cancer (14/17, p < 0.01). Conclusions: Geriatric evaluation did influence final therapeutic decision in 79 % of elderly patients in our study. Follow up and updated data will be presented to evaluate quality of final therapeutic decision. No significant financial relationships to disclose.
Abstract 2143: Improved Long-Term Survival in a High Risk Population Following Drug Eluting Stent Availability
Authors: Maheer Gandhavadi, Kendrick A Shunk, Edward J McNulty
Journal: Circulation (2007)

Background Data regarding the impact of drug eluting stent (DES) use on long-term outcomes outside trial populations are limited. Methods 1,547 consecutive patients underwent stent implantation from January 2000 until December 2006 at the San Francisco Veterans Affairs Medical Center. To assess the impact of DES availability on mortality, that population was partitioned into a pre-DES cohort (N=591) and a post-DES availability cohort (N=956). Kaplan-Meier survival curves for the two cohorts were compared. Results The entire population was relatively high risk: 37% had diabetes, 38% a reduced ejection fraction, and 53% a prior MI or elevated troponin prior to the procedure. Median follow up was 4.7 years for the pre-DES cohort and 1.8 years for the post-DES cohort. DES were used in 83% of procedures in the post-DES cohort. Survival improved significantly in the post-DES cohort (P = .04, Log Rank)(see Figure ). Baseline characteristics, procedural variables and discharge medications were analyzed in a Cox proportional hazards model (see Table ). DES use was an independent predictor of improved survival (Hazard Ratio for death 0.52, 95% CI .28–.95). Conclusions In an unselected, high risk population, long-term survival improved following the availability of drug eluting stents. After adjusting for potential confounding factors, DES use was an independent predictor of improved survival. Independent Predictors of Death in all 1,547 Patients
THE SYNOVIAL MEMBRANES.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tetanus and diphtheria immunity in urban Minnesota adults
Authors: K. Crossley
Journal: JAMA (1979)

Tetanus and diphtheria antitoxin levels were measured in 183 urban adults, using a hemagglutination technique. Protective levels (&gt;0.01 unit/mL) of tetanus antitoxin were present in more than 85% of sera from all subjects under 40 years of age and from men between 40 and 59 years old. A minority of women (36%) between 40 and 59 years of age, and of men (41%) and women (29%) over 60 years of age, were protected. Less than one quarter of the study group had protective levels (&gt;0.01 unit/mL) of diphtheria antitoxin. The results of this study suggest that a minority of middle-aged women and older adults have been appropriately immunized against diphtheria and tetanus. (<i>JAMA</i>242:2298-2300, 1979)
For Knee Trauma
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal