tbuckley/cabot-search huggingface dataset:
Differential expression of A and B laminin chains during rat liver regeneration
Authors: A GIMENEZ
Journal: Hepatology (1995)

We have studied the distribution and expression of laminin during rat liver regeneration by immunofluorescence and immunoblotting using affinity-purified laminin antibodies. Laminin was localized on sinusoidal surfaces in normal and regenerating hepatic parenchyma, but enhanced expression was detected during regeneration from 6 hours to 7 days after a partial hepatectomy. A and B laminin chains were specifically detected by Western blotting in highly purified plasma membrane fractions derived from the sinusoidal domain of hepatocytes. Analysis of laminin expression in whole homogenates from hepatectomized rats showed a differential expression of A and B laminin chains during regeneration: The A chain showed a progressive increase, whereas the B chain exhibited an early, prereplicative increase and then gradually declined to control levels at the end of restorative growth. The results suggest differential temporal requirements for A and B laminin chains during hepatic growth and tissue formation.
Therapeutic efficacy of the chitotriosidase inhibitors in STAM model of non-alcoholic steatohepatitis
Authors: Michal Mlacki, Barbara Dymek, Agnieszka Zagozdzon, Marzena Mazur, Robert Koralewski, Adam Golebiewski, Karolina Dzwonek, Pawel Dobrzanski
Journal: Journal of Hepatology (2020)
MISCELLANY.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Magnesium Toxicity.
Authors: R. E. Randall
Journal: Annals of Internal Medicine (1963)

s1 April 1963Magnesium Toxicity.R. E. Randall Jr., M.D.R. E. Randall Jr., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-4-744_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe toxic effects of an elevated serum magnesium have been known for years but not widely recognized nor systematically studied in man. Six patients have been studied who developed significant hypermagnesemia while receiving magnesium compounds either parenterally or orally as antacids or laxatives (milk of magnesia, magnesium sulfate, and Maalox®). Hypotension, respiratory failure, and hyporeflexia developed in 3 instances, coma in 4, pronounced electrocardiographic changes in at least one, and sudden death from cardiac arrest in 1 instance. Renal failure, present in all patients, was believed principally responsible for the retention of magnesium while obstipation may have been a contributing... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Mass. (CI) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByMetabolically programmed iron chelatorsDesferrithiocin: A Search for Clinically Effective Iron Chelators 1 April 1963Volume 58, Issue 4Page: 744-744KeywordsHeartHypermagnesemiaHypotensionMagnesiumMilkRenal failureRespiratory failureSudden cardiac deathSulfatesToxicity Issue Published: 1 April 1963 PDF DownloadLoading ...
Joint Hypermobility--Asset or Liability? A Study of Joint Mobility in Ballet Dancers
Authors: R. Grahame, J. M. Jenkins
Journal: Annals of the Rheumatic Diseases (1972)

steroids on any other patients than rheumatoids using this technique?DR.VERNON-ROBERTS We intended to carry out a further investigation on patients before and during therapy to evaluate them clinically by one of the recog- nized indices.We did not carry this out in the investigation presented, but Dr. Jessop made a clinical assessment of disease activity and we found a significant correlation between this and the phagocytic scores of macrophages in the untreated patients with rheumatoid arthritis, which gives us encouragement to continue this investigation.Regarding your second point, we had a few patients not included in this series who had polymyalgiarheumatica and were on steroids.They exhibited marked depression compared to our control group.DR. A. G. MOWAT (Oxford) These are two very nice
Twin dilemma
Authors: S. Arie
Journal: BMJ (2014)

<h3>Abstract</h3> One of the most important public health challenges facing the world today is that posed by antibiotic resistance. Many pathogenic antibiotic-resistant bacteria and their antibiotic resistance genes, usually located on mobile genetic elements, are frequently present in the faeces of farm animals. To prevent the possibility of antimicrobial resistance transfer to the environment, these faeces should undergo treatment before being used as natural fertilizer. The two strategies for processing pig manure proposed in this study, <i>viz.</i> storage (most commonly used for livestock manure today) and composting, are cheap and do not require special tools or technologies. The present study examines the changes in the physicochemical properties of treated manure, in the microbiome, through metagenomic sequencing, and in the resistome, using the SmartChip Real-time PCR system compared to raw manure. This is the first such comprehensive analysis performed on the same batch of manure. Our results suggest that while none of the processes completely eliminates the environmental risk, composting results in a faster and more pronounced reduction of mobile genetic elements harbouring antibiotic resistance genes, including those responsible for multi-drug resistance. The physicochemical parameters of the treated manure are comparable after both processes; however, composting resulted in significantly higher organic matter. Overall, it appears that the composting process can be an efficient strategy for mitigating the spread of antibiotic resistance in the environment and reducing the risk of its transfer to agricultural crops and hence, the food chain. It also provides the organic matter necessary for humus formation, and increases the sorption properties of the soil and the micro and macro elements necessary for plant growth, which in turn translates into increased soil productivity. <h3>Highlights</h3> The changes in microbial population composition correlate with changes in specific antibiotic-resistance genes and mobile genetic elements in the studied populations. Positive correlations have been demonstrated between microbial phyla and genes coding the multi-drug resistance mechanism Co-occurrence networks showed positive correlations between antibiotic-resistance genes and mobile genetic elements The composting strategy was most efficient at reducing microbial loads, antibiotic resistance genes and mobile genetic elements. Composted manure can be part of a natural, safe soil fertilization strategy.
Psychic Side Effects of a Chlorzoxazone and Acetaminophen Mixture
Authors: Paul C. Liederman
Journal: JAMA (1967)

A mixture of chlorzoxazone, 250 mg, and acetaminophen, 300 mg (Parafon Forte) was administered in tablet form to a 21-year-old man. The patient had received no previous medication and had no history of food or drug allergies. Following ingestion of the tablets, the patient experienced headaches, spatial disorientation, a dream-like state, nausea, vomiting, peripheral paresthesias, and amnesia. Several of these symptoms have not been previously reported as side effects of this medication. The side effect symptoms appeared to be directly related to the ingestion of the mixture; all symptoms cleared 24 hours after the medication was discontinued.
"Immune" Reaction
Authors: Geoffrey Edsall
Journal: JAMA (1964)

<h3>To the Editor:—</h3> The current edition of the<i>American Academy of Pediatrics Red Book</i>refers, on page 16, to the three familiar reactions to smallpox vaccination as "(1) primary vaccinia, or typical reaction, or a 'take'; (2) vaccinoid, or accelerated reaction; and (3) early, or 'immediate' reaction (mistakenly termed 'immune reaction')." The fallacy of the term "immune reaction" is now universally recognized by people working in this field; the reaction does not of itself indicate immunity, and to call it an "immune reaction" may lead to a dangerously false sense of security in patients who exhibit such a reaction. Therefore, I hope that a note of correction on this point can be published, in view of the reference to the so-called immune reaction in the editorial "More About Smallpox" inThe Journalof Jan 18, 1964 (<b>187</b>: 224).
Correction
Journal: BMJ (1929)

IKZIAONA based uponl a figure of accommodation whicil, in the opiniioni of the Commissioni, was 10,000 beds short of wliat was reasonably necessary.If this (leficienicy had niot existed the ratio of beds to population would liave beeni 1.6 per" 1,00, anld the Coimimission thought that this represeuted the rate at which the hospitals shouild expaud to keep pace with the growth of population.
Book Review The Diagnosis and Treatment of Chronic Diseases of the Respiratory Tract . With Especial Reference to the Lesions of the Trachea, Bronchi, Lungs, Pleura and Diaphragm. Elmer H. Funk. Revised by Burgess Gordon. Edited by Henry A. Christian. 618 pp. New York: Oxford University Press.
Journal: New England Journal of Medicine (1937)
学前儿童特应性皮炎和青少年接触性过敏
Authors: M. Lagrelius, C.‐F. Wahlgren, M. Matura, A. Bergström, I. Kull, C. Lidén
Journal: British Journal of Dermatology (2019)

特应性皮炎是儿童中的一种常见皮肤病。此病表现为瘙痒的红色鳞屑性皮肤,可导致皮肤屏障削弱。当特应性皮炎开始于儿童期初期时,儿童可能长期接受药用乳膏和润肤剂治疗。这些产品通常包含可能导致接触性过敏的物质。当皮肤接触过敏性化学物质(如接触性过敏原)时导致接触过敏。重复接触过敏原将导致皮炎。这项研究调查儿童期初期的特应性皮炎是否会增高青少年阶段接触性过敏的风险。在瑞典 2215 名 16 岁参与者中进行了此项研究。作为一项被称为 BAMSE 研究的大型人群研究的一部分,从出生起通过问卷、临床检查和血液检查追踪这些 16 岁参与者,以研究儿童中的环境因素和过敏症。这些参与者在 16 岁时通过皮肤斑贴试验接受接触过敏检测。镍过敏是最常见的接触过敏,香料(香水)第二常见。这项研究的结果显示,儿童期初期的特应性皮炎可能增高 16 岁时香水接触过敏的风险,但不会增高 16 岁时镍过敏的风险。这项研究显示,在儿童期初期有特应性皮炎的儿童中避免使用有香味和含香水的产品是一个好主意。
The Cover
Authors: Laura King
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 5190: EZH2 epigenetically silences anti-tumor immunity in melanoma via dual histone and DNA methylation
Authors: Jessamy Tiffen, Dilini Gunatilake, Stuart Gallagher, Peter Hersey
Journal: Cancer Research (2019)

Abstract Despite major advances in immuno- and targeted therapies for metastatic melanoma, not all patients respond to such treatments and the development of therapy resistance remain key obstacles. Novel targets are required and the epigenetic modifier EZH2 may represent such a solution. EZH2 methylates histones causing chromatin compaction and silencing of gene expression. Additionally, EZH2 has been shown to interact with DNA methyltransferases (DNMTs). Aberrant EZH2 in cancer results in the silencing of hundreds of tumor suppressor genes that would normally constrain cancer growth, and 26% of patients in the Australian Melanoma Genome Project (AMGP) display such abnormal EZH2. Using ChIP-seq, microarrays and DNA methylation sequencing, we identified a subset of EZH2 target genes that are silenced by both histone and DNA methylation in melanoma. Interestingly many of these genes play a role in the anti-tumor immune response, including RASSF5 and ITGB2 that facilitate lymphocyte infiltration into tumors and correlate with better survival outcomes in melanoma patients when their expression is high. We show that such genes can be significantly up-regulated by combined treatment with inhibitors of both EZH2 and DNMT in melanoma cells in vitro. Our studies suggest that aberrant EZH2 in melanoma drives aggressive disease via suppression of genes that would normally trigger the anti-tumor immune response. The progression of several preclinical, small molecule inhibitors of EZH2 and DNMTs remains promising. Citation Format: Jessamy Tiffen, Dilini Gunatilake, Stuart Gallagher, Peter Hersey. EZH2 epigenetically silences anti-tumor immunity in melanoma via dual histone and DNA methylation [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 5190.
Toward a Comprehensive Developmental Model for Major Depression in Men
Authors: Kenneth S. Kendler, Charles O. Gardner, Carol A. Prescott
Journal: American Journal of Psychiatry (2006)

OBJECTIVE: The multiple risk factors for major depression are interrelated through poorly understood developmental pathways. In 2002, the authors presented a developmental model for major depression in women. Based on similar methods, they here present an analogous model for men. METHOD: Using data from 2,935 adult male twins, interviewed twice over a 2–4-year period, the authors constructed, by means of structural equation modeling, an integrated etiologic model for major depression that predicts depressive episodes over 1 year from 18 risk factors conceptualized as five developmental “tiers” reflecting childhood, early adolescence, late adolescence, adulthood, and the last year. RESULTS: The best-fitting model, including six correlations and 76 paths, provided a good fit to the data, explaining 49% of the variance in the liability to depressive episodes. The overall results, similar to those seen in women, suggest that the development of major depression results from the action and interaction of three broad pathways of internalizing symptoms, externalizing symptoms, and adversity. Childhood parental loss and low self-esteem were more potent variables in the model in men than in women. Genetic risks for major depression had a broader spectrum of action in men than in women. The pathway to major depression through externalizing symptoms was not more prominent in men than in women. CONCLUSIONS: Major depression in men, as in women, is an etiologically complex disorder influenced by risk factors from multiple domains that act in developmental time. The similarities in etiologic pathways to major depression for men and women outweigh the modest differences.
Passionate kissing and microlesions of the oral mucosa: possible role in AIDS transmission
Authors: M. Piazza
Journal: JAMA (1989)

<h3>To the Editor.—</h3> Kissing generally is considered protective sex.<sup>1</sup>We do not agree, since the oral mucosa is very fragile. In fact, hepatitis B infection may occur by the oral route through microlesions present in the oral mucosa (inapparent-parenteral route)<sup>2,3</sup>and not by the classic enteric route.<sup>4</sup> Since it is impossible to verify the presence of microlesions in the oral mucosa by inspection, we suggest that the presence of blood in saliva is indirect evidence of them. After encouraging preliminary results,<sup>5</sup>we have verified this phenomenon by carrying out the following experiment. <h3>Study. —</h3> Ninety healthy subjects (mean age, 25 years; range, 17 to 35 years) forming 45 heterosexual couples completed this study. Each subject was given six containers numbered 1 to 6 and was asked to collect saliva after carrying out the following three events in their normal way: immediately before and two or three
Tibial lesion in a Laotian girl
Authors: D. L. Day
Journal: JAMA (1985)

<h3>History</h3> A 14-year-old Laotian girl presented with a history of persistent and increasing pain in the proximal segment of the left leg after being hit with a hockey stick one month before. Over the past several months, she had a 6.8- to 9.0-kg (15- to 20-lb) weight loss and had recently experienced lethargy and fever with temperature to 38.8 °C (102 °F). The patient had spent the first 12 years of life in Laos. While she was in Laos just prior to her arrival in the United States, a "lump" in the right side of her neck had been resected. Information covering the pathological interpretation of the sections obtained from the resected mass in the neck is withheld. Physical examination showed a cachectic Laotian girl with a tender, swollen left leg in its proximal segment. Cervical adenopathy and a 1.5×1.5-cm right supraclavicular mass were present. A roentgenogram of the left
Urban Air Pollution and Health Inequities: A Workshop Report
Journal: Environmental Health Perspectives (2001)

Over the past three decades, an array of legislation with attendant regulations has been implemented to enhance the quality of the environment and thereby improve the public's health. Despite the many beneficial changes that have followed, there remains a disproportionately higher prevalence of harmful environmental exposures, particularly air pollution, for certain populations. These populations most often reside in urban settings, have low socioeconomic status, and include a large proportion of ethnic minorities. The disparities between racial/ethnic minority and/or low-income populations in cities and the general population in terms of environmental exposures and related health risks have prompted the "environmental justice" or "environmental equity" movement, which strives to create cleaner environments for the most polluted communities. Achieving cleaner environments will require interventions based on scientific data specific to the populations at risk; however, research in this area has been relatively limited. To assess the current scientific information on urban air pollution and its health impacts and to help set the agenda for immediate intervention and future research, the American Lung Association organized an invited workshop on Urban Air Pollution and Health Inequities held 22-24 October 1999 in Washington, DC. This report builds on literature reviews and summarizes the discussions of working groups charged with addressing key areas relevant to air pollution and health effects in urban environments. An overview was provided of the state of the science for health impacts of air pollution and technologies available for air quality monitoring and exposure assessment. The working groups then prioritized research needs to address the knowledge gaps and developed recommendations for community interventions and public policy to begin to remedy the exposure and health inequities.
The Wellsprings of Medical Science
Authors: J. R. E.
Journal: Annals of Internal Medicine (1963)

Editorials1 June 1963The Wellsprings of Medical ScienceJ. R. E.J. R. E.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-6-1051 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe wellsprings of medical science are many: compassion for the sick, understanding of the possibilities of the scientific method, intellectual curiosity, individual initiative, opportunity to exercise such curiosity and initiative alone or in collaboration with like-minded seekers after truth, a climate of intellectual freedom. Any threat to any of these factors threatens the progress of medical science and hence the health of the nation—a matter of grave concern to the medical community as well as to the public at large. Two such threats to this progress loom in present activities of the Congress. The first of these is the introduction...References1. Editorial: Congress and the laboratory animal. New Eng. J. Med. 268: 899, 1963. CrossrefGoogle Scholar2. Policy and information statement on research grants. Grant and Award Program of the Public Health Service, Vol. 1, United States Department of Health, Education, and Welfare, Bethesda, 1959, p. 3. Google Scholar3. ABELSON PH: Editorial: More paper work, less research. Science 139: 1963. CrossrefMedlineGoogle Scholar4. MILLER JE: How Newton discovered the law of gravitation. Amer. Sci. 39: 134, 1951. Google Scholar5. PARKINSON CN: Parkinson's law on medicine and medical research. Clin. Res. 10: 265, 1962. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *HR 4856—the Randall Bill.HR 4620—the Ashley Bill.S 533—the Clark-Neuberger Bill. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1963Volume 58, Issue 6Page: 1051-1053KeywordsExercise Issue Published: 1 June 1963 PDF downloadLoading ...
Infectious complications in four long-term recipients of the Jarvik-7 artificial heart
Authors: C. M. Kunin
Journal: JAMA (1988)

This article describes the infectious complications that occurred among four of the longest-term recipients of the Jarvik-7 artificial heart. Infection arising from the drive lines, with spread to the mediastinal periprosthetic space, was the major limiting factor in long-term use of the device in these patients. Periprosthetic infections were due to coagulase-negative staphylococci,<i>Staphylococcus aureus, Pseudomonas aeruginosa</i>, and other<i>Pseudomonas species</i>. Other infectious complications incurred by some of the patients included pneumonia, empyema, urinary tract infection, and intravascular line sepsis with<i>Candida</i>. Intensive antimicrobial therapy for prolonged periods seemed to suppress but not to eradicate infection and was accompanied by the appearance of multiresistant bacterial strains. Complications of antimicrobial therapy included diarrhea secondary to overgrowth with<i>Clostridium difficile</i>in two patients. Use of the current device for more than 30 days should be considered extraordinary and should be reserved for patients for whom no other form of life support is available. (<i>JAMA</i>1988;259:860-864)
Cover Image, Volume 38, Issue 2
Authors: Fubo Zhou, Wenting Shang, Xiaoling Yu, Jie Tian
Journal: Medicinal Research Reviews (2018)

On the cover: The cover image, by Fubo Zhou et al., is based on the Review Article Glypican-3: A promising biomarker for hepatocellular carcinoma diagnosis and treatment, https://doi.org/10.1002/med.21455.