tbuckley/cabot-search huggingface dataset:
Nutrition Bulletin
Journal: Gut (1977)

This book reports on the papers and discussion at a symposium of which the date and site are unfortunately not men- tioned in the book. (On inquiry, the pub- lishers tell us that it was held at the Welsh National School of Medicine on 7, 8, and 9 July 1975 and that it was a Postgraduate Course in paediatric gastro- enterology organised by J. A. Dodge).It covers development of the gut in the fetus and young children; infancy and its problems; diarrhoea; abdominal pain, and constipation.It conveniently brings together much valuable scattered infor- mation, but the price seems high for a paperback.
Occupational solvent exposure and glomerulonephritis. A case report and review of the literature
Authors: W. E. Daniell
Journal: JAMA (1988)

We describe a patient who presented with renal failure after a one-year period of unprotected heavy occupational exposure to organic solvents. Renal biopsy results and serological findings were diagnostic of anti—glomerular basement membrane antibody—mediated glomerulonephritis. An analytic review of the literature revealed substantial evidence linking solvent exposure to the development of glomerulonephritis (GN), with seven of nine case-control studies demonstrating a statistically significant association. Odds ratios were reported by or could be calculated for six of these studies, and the five positive studies detected a 2.8- to 8.9-fold increased risk for GN among solvent-exposed individuals. The findings in several of these studies of dose-response relationships, the reports of variations in disease severity in relation to exposure intensity, and the absence of alternative explanations for the association provide additional supportive evidence for a solvent effect. In the majority of cases of anti—glomerular basement membrane antibody—mediated GN and other types of GN, there is no remarkable preceding exposure to organic solvents. However, we conclude that in the case presented herein and in cases of GN with similar exposure histories, solvent exposure may play a significant contributing role in the development of GN. (<i>JAMA</i>1988;259:2280-2283)
THE SUCCESS OF THE BOSTON SESSION.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The ovary.
Authors: S. L. Wilens
Journal: JAMA (1963)

This volume represents a relatively new type of medical publication, the symposium-sponsored monograph authored by a group of outstanding specialists in a particular field. Such books present up-to-date developments and indicate future trends of investigation. As such they are invaluable. The present book is an unusually fine example of the usefulness of this type of presentation. Its fourteen papers are logically arranged and cover all important phases of ovarian physiopathology. It provides an impressive demonstration of our continuously accruing knowledge. A generation hence, one may expect a volume devoted entirely to the vicissitudes of a single cell—the ovum. The book, to some extent, suffers from the lack of continuity and complete coverage usually found in those produced by a single author. There is some duplication in text and illustration. For example, the effects of follicle-stimulating hormone are expounded repetitiously in several presentations and there are a number of almost identical
Central Repository for Contraceptive Steroid Tissue Evaluation
Journal: JNCI Journal of the National Cancer Institute (1973)

Central Repository for Contraceptive Steroid Tissue Evaluation Get access JNCI: Journal of the National Cancer Institute, Volume 50, Issue 3, March 1973, Page 819, https://doi.org/10.1093/jnci/50.3.819 Published: 01 March 1973
Reply
Authors: C. Feighery, D. Weir, A. Whelan
Journal: Gut (1990)

SIR, -The comments of Drs Colombel, Janin, and Torpier are of interest.We agree that the immune processes which may contribute to the mucosal lesion of coeliac disease may be multifactorial.The eosinophil is a major com- ponent of the inflammatory infiltrate in coeliac disease, although this is frequently not emphasised in descriptions of the lesion.We have recently produced additional evidence that eosinophils and polymorphs are present in increased numbers in the coeliac mucosa: using monoclonal antibodies to Fc receptors (for the gamma chain of IgG) types II and III, which are found on eosinophils and polymorphs, a marked increase in reactive cells was found.The evidence of Dr Colombel and colleagues that many of these eosinophils have degranulated and the associated finding of increased release of granule components points to mech- anisms whereby eosinophils might mediate damage.The possibility that IgA, produced in large quantities in the damaged intestine, may be involved in eosinophil degranulation through interaction with IgA Fc receptors should also be considered.The finding that many coeliac patients react rapidly to gluten challenge (both symptomatically and histologically) is in keeping with more immediate mechanisms of damage also participating in the development of the lesion.Eosinophils are good candidates for such a mechanism.
Pressure ulcer prevention with low-air-loss beds
Authors: R. B. Verdery
Journal: JAMA (1993)

<h3>In Reply.</h3> —Thank you for allowing us to respond to concerns expressed by Dr Verdery regarding our article, which examined the clinical utility and cost-effectiveness of an air suspension bed in the prevention of pressure ulcers. First, he was concerned about the lack of blinding in the diagnosis and categorization of stage I ulcers. As stated in our methods, blinding was impossible. Therefore, we instituted a process to minimize this bias as much as possible. Specifically, with detection and staging of a pressure ulcer by the study nurse, our hospital's skin care team was consulted. The consultant dermatologist then independently addressed the issue of presence or absence of pressure ulcers and staged them when applicable. Our interrater agreement was good (κ&gt;0.80). Second, Verdery noted we had not mentioned whether a specific treatment protocol was instituted. The study's objective was to address prevention, not treatment. Thus, treatment of established ulcers was
Health Promotion
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ADVERTISING SHEETS, ETC.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nephritis and Allied Diseases: Their Pathogeny and Treatment
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Anaesthesia for dental extractions.
Journal: BMJ (1967)

rilsMEDICAL JOURNA 447 relatives.3Most recently S. P. Balcerzak and colleagues from the U.S.A. have reported increased body stores of iron in 13 out of 28 relatives from three families studied in detail.4The pattern of inheritance is variously described as dominant with incomplete expression or recessive with the heterozygote showing some abnormality.The clinical association of the fully developed disease with alcoholism' suggests, however, that environmental factors in addition to a genetic defect are necessary for full expression of the disease.Recently P. S. Davis and his colleagues5 have reported decreased amounts of gastric iron-binding protein; a substance which it is believed normally inhibits absorption of iron.On the other hand, A. Mazur and M. Sackler6 have found abnorrmally low levels of xanthine-oxidase activity in the liver, and suggest that this leads to a slow release of hepatic iron.This together with a moderate increase in absorption could account for progressive accumulation of iron in the tissues.The absorption of iron, however, is usually within the normal range.The basic defect is not clearly known.Absorption of iron is within the normal range when the patient is first seen,47 though it increases rapidly during venesection therapy and remains high in the majority of cases followed up after com- pletion of treatment.7 Increases in absorption of iron have also been found in the relatives.In one series 55% of 29
Comprehensive genomic profiling (CGP) in patients with relapsed/refractory germ cell tumors (GCT).
Authors: Reem Akel, Bilal Anouti, Sean Kern, Clint Cary, Timothy A. Masterson, Joseph M Jacob, Gennady Bratslavsky, Natalie Danziger, Dean Pavlick, Nasser H. Hanna, Lawrence H. Einhorn, Jeffrey S. Ross, Nabil Adra
Journal: Journal of Clinical Oncology (2021)

388 Background: Understanding the genetic alterations in patients with relapsed/refractory GCT (rrGCT) could delineate the pathogenesis of cisplatin resistance. Our study uses CGP to characterize genomic alterations (GA) in refractory GCT and correlate with clinical outcomes. Methods: 432 patients with rrGCT were seen at Indiana University between Jan 2016 to Sep 2019 of whom 52 patients underwent CGP using a hybrid-capture based commercial assay to evaluate all classes of GA. Tumor mutational burden (TMB) was determined on 1.1 Mbp of sequenced DNA and reported as mutations/Mb and microsatellite instability (MSI) was determined on 114 loci. PDL1 expression was determined by IHC (DAKO 22C3 antibody). Results: All patients relapsed after first-line cisplatin-based combination chemotherapy. Median age at diagnosis was 33 (range 15-68). Primary site of GCT was testicular in 85% and mediastinum in 8%. 6 patients had pure seminoma and 46 had non-seminoma. Platinum refractory disease, defined as serologic or radiographic progression within 4 weeks of first-line chemotherapy comprised 23% of patients. The primary tumor was used for sequencing in 6 cases (12%) and non-primary tumor metastatic site (lymph node, lung, liver, brain, omentum) in 46 cases (88%). The most common GA in the entire cohort were FGF6 (27%), FGF23 (27%), KDM5A (27%), CCND2 (27%), KRAS (18%), TP53 (14%), KIT (8%), APC (8%), ZNF217 (6%), MUTYH (6%), AURKA (6%), NRAS (6%), EGFR (6%), CTNNB1 (6%), GNAS (6%). Most common alterations for testicular primary tumors were FGF6, FGF23, KDM5A, CCND2, KRAS, TP53, KIT. For non-testicular primary GCT, most common GA were APC, TP53, EGFR. Most common GA for non-seminoma were FGF6, FGF23, KDM5A, CCND2, KRAS, TP53, APC. Most common GA for pure seminoma was KIT. Potentially targetable genomic alterations were found in 17 patients (33%). 10 of 17 patients (59%) tested had PDL1 score ≥1% and 3 patients had PDL1 ≥50%. Median TMB was 3.5 mutations/MB. There were 4 patients (8%) with TMB ≥ 10 mutations/Mb and 2 patients (4%) with TMB ≥ 20 mutations/Mb. 1 of 48 patients (2%) evaluated for MSI had MSI-High status. Isochromosome 12p was detected in the majority of samples where it was tested. Outcomes with GA-directed therapy will be presented at the conference. Conclusions: CGP can reveal potential therapeutic targets in patients with rrGCT including EGFR, ERBB3, KIT, and MET. Consistent with reported clinical trials in rrGCT, biomarkers predicting response to immune checkpoint blockade are uncommon with most patients having low TMB, absence of MSI-H status, and low expression of PDL1.
Biological Effects of Short-Term, High-Concentration Exposure to Methyl Isocyanate. IV. Influence on the Oxygen-Binding Properties of Guinea Pig Blood
Authors: Leigh A. Maginniss, Joseph M. Szewczak, Catherine M. Troup
Journal: Environmental Health Perspectives (1987)

Whole blood oxygen equilibrium curves (O2 ECs), blood buffer lines, and several hematologic properties were determined for adult guinea pigs exposed to 700 ppm methyl isocyanate (MIC) for 15 min. MIC inhalation effected a significant reduction of blood O2 affinity; the half-saturation pressure (P50) at 38 degrees C increased from the control (untreated) level of 22.8 +/- 0.1 mm Hg to values ranging from 28.5 to 43.7 mm Hg for experimental animals. MIC exposure had no apparent influence on O2 EC shape or CO2 Bohr effect. Erythrocyte volume, [metHb], O2 binding capacity, and combined red cell organic phosphate concentration (DPG + ATP) were not affected by MIC treatment. However, experimental animals experienced a severe metabolic acid-base disturbance; blood lactate concentration ranged from 8.6 to 24.0 mmole/L. Results indicate that lactic acidosis was solely responsible for increased blood P50 of MIC-treated animals. No direct effects of MIC on hemoglobin function were observed. Reduced Hb-O2 affinity, in conjunction with severe hypoxemia, compromised the guinea pigs' capacity for pulmonary O2 loading; at PaO2 of 30 mm Hg, Hb-O2 saturation (S) decreased from 66% S for controls to 42% S for MIC-treated animals.
Abstract 19159: Assessment of Myocardial Viability After Acute Myocardial Infarction: A Head-to-head Comparison of the Perfusable Tissue Index by PET and Delayed Contrast-enhanced CMR
Authors: Stefan A Timmer, Paul F Teunissen, Ibrahim Danad, Laurens F Robbers, Pieter Raijmakers, Aernout M Beek, Albert C van Rossum, Adriaan A Lammertsma, Niels van Royen, Paul Knaapen
Journal: Circulation (2014)

Introduction: Early recognition of viable myocardium is of great clinical importance after acute myocardial infarction (AMI). Delayed contrast-enhanced magnetic resonance imaging (DCE-CMR) has been validated extensively for the detection of viability. An alternative method for detecting viability is the perfusable tissue index (PTI), a positron emission tomography (PET) derived parameter, which is inversely related to the extent of myocardial scar (nonperfusable tissue). Aims: To investigate the predictive value of PTI on recovery of LV function after percutaneous coronary intervention (PCI) for AMI. Methods: Twenty-six patients with AMI successfully treated by PCI were included. Subjects were examined one week and three months after AMI with [15O]H2O PET and DCE-CMR to assess PTI, regional function and scar. Viability was defined as recovery of systolic wall thickening (SWT) ≥ 3.0 mm at follow-up. Results: A total of 396 segments were available for serial analysis. At baseline, 166 segments were dysfunctional, of which 125 (75%) exhibited significant DCE and were located in the myocardial territory supplied by the culprit-artery. Fourty-nine of these dysfunctional segments showed full recovery during follow-up (viable), whereas 76 segments remained dysfunctional (nonviable). Baseline PTI of viable segments was 0.94 ± 0.07 and was significantly higher compared to nonviable segments (0.80 ± 0.11, p = 0.01). The optimal cut-off value for the PTI was 0.85 with a sensitivity of 92% and specificity of 71%, and an area under the curve (AUC) of 0.88. In comparison, a cut-off value of 40% for the extent of DCE resulted in a sensitivity of 75% and a specificity of 65%, and an AUC of 0.75 (p = 0.02 vs PTI). Conclusions: This study shows that assessment of myocardial viability shortly after reperfused AMI is feasible with PET, and that the PTI is a good prognostic indicator for recovery of contractile function when compared to DCE-CMR.
Abstract 3525: Achieving reproducibility and accuracy in cancer mutation detection with whole-genome and whole-exome sequencing
Authors: Wenming Xiao
Journal: Cancer Research (2019)

Abstract Clinical applications of precision oncology require accurate tests that can distinguish tumor-specific mutations from errors introduced at each step of next generation sequencing (NGS). For NGS to successfully improve patient lives, discriminating between true mutations and artifacts is crucial. We systematically interrogated somatic mutations in paired tumor normal cell lines to identify factors affecting detection reproducibility and accuracy. Different types of samples with varying input amount and tumor purity were processed using multiple library construction protocols. Whole-genome and whole-exome sequencing were carried out at six sequencing centers followed by processing with nine bioinformatics pipelines to evaluate their reproducibility. We identified artifacts due to sample and library processing and evaluated the capabilities and limitations of bioinformatics tools for artifact detection and removal. By examining the interaction and effect of various wet lab and computational parameters concomitantly, here we recommend actionable best practices for mutation detection in clinical applications using NGS technologies. Citation Format: Wenming Xiao, The Somatic Mutation Working Group of the SEQC-IIConsortium. Achieving reproducibility and accuracy in cancer mutation detection with whole-genome and whole-exome sequencing [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3525.
Editor's Choice
Journal: British Journal of Dermatology (2014)

Evidence-based guidelines for laboratory screening for infectious diseases before initiation of systemic immunosuppressive agents in patients with autoimmune bullous dermatosesTh is study from dermatologists of the Mayo Clinic in the U.S.A. aimed to establish evidence-based guidelines for pretreatment testing for infectious diseases in patients with autoimmune bullous dermatoses (ABDs).Th e authors state that there are no pretreatment infection testing guidelines available for clinicians caring for patients with ABDs.Th ey performed a systematic literature review in other medical disciplines that use similar iatrogenic immunosuppressive medications to treat various diseases and conditions.Th ey used this to develop infection testing recommendations for patients with ABDs before initiating immunosuppressive therapy.Th ey state that assess-ing individual patient risk factors for latent infection and preventable communicable diseases can direct testing for selected infections before starting immunosuppressive therapy.Th ey conclude that testing patients with ABDs should include investigation for hepatitis B virus, hepatitis C virus and Mycobacterium tuberculosis infection before initiating rituximab treatment.
Office use of microcomputers now extends into clinical realm
Journal: JAMA (1984)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal