tbuckley/cabot-search huggingface dataset:
Protein products for dieting may sport warning labels
Authors: P. Gunby
Journal: JAMA (1980)

Legal skirmishing continues in the federal government's effort to require warning labels on "liquid protein" and other protein products intended for use in weight reduction or as diet supplements. Food and Drug Administration officials have been seeking the warning labels for three years (<i>JAMA</i>[MEDICAL NEWS] 1977;238:2243-2244, 2680) after becoming concerned "about the rapidly growing use of liquid protein products that were being used as the primary or sole source of calories in low-calorie diets." Seventeen deaths have been attributed to use of these products. In the absence of supervision to ensure adequate potassium intake, hypokalemia is a possibility, the FDA has said. Cardiac arrhythmias may also occur (<i>N Engl J Med</i>1980;303:735-738). A regulation requiring the warning labels was to have gone into effect Sept 4, but a federal judge granted a stay to those opposing it. The FDA officials say the court has directed them "to do some more
Diphenylhydantoin Hypersensitivity Treatment With 6-Mercaptopurine
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hypertension control: a succeeding national effort
Authors: R. L. Levy
Journal: JAMA (1979)

May is National High Blood Pressure Month. In a nation overly accustomed to "diseases of the month," this event is not remarkable. What is remarkable is that May is the fifth High Blood Pressure Month and that in the short history of these months, the United States has accomplished an unprecedented near revolution in its approach to control of this major contributor to cardiovascular disease. Much has been learned during this revolution, not the least of which is that having a month can be far more than an idle gesture if it is executed within a well-planned public health effort. Such an effort does exist. It is the National High Blood Pressure Education Program, initiated in 1972 and coordinated by the National Heart, Lung, and Blood Institute.<sup>1,2</sup>It is succeeding, although it is not yet totally successful. The National High Blood Pressure Education Program, when initiated in 1972, faced
GALLSTONES AND PANCREATITIS.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Peer review and the NCI's clinical alert on node-negative breast cancer
Authors: B. A. Feinberg
Journal: JAMA (1989)

<h3>To the Editor.—</h3> On May 16, 1988, the National Cancer Institute (NCI) released a media statement in conjunction with a letter to 13 000 cancer specialists regarding new recommendations on adjuvant therapy for breast cancer. The letter, entitled "NCI Clinical Alert Urgent," heralds a major change in longstanding policy, recommending adjuvant systemic therapy for node-negative breast cancer.<sup>1</sup> The unorthodox method by which this information was disseminated has been explained as an effort to reach physicians quickly rather than waiting months for the data from the three referenced studies to be published. However, the NCI was unusually quiet in releasing the information to the public, choosing to rely on a mailed press release rather than a formal news conference. Furthermore, the mailing to cancer specialists disregards the fact that most women with node-negative breast cancer are evaluated solely by their primary care physician and general surgeon. There are several inconsistencies
Abstract 13473: Refinement of a Risk-Standardization Model for Adverse Outcomes Following Congenital Cardiac Catheterization: Insights From from the NCDR <sup>®</sup> IMPACT <sup>TM</sup> Registry
Authors: Natalie Jayaram, John A Spertus, Kevin F Kennedy, Robert N Vincent, Gerard R Martin, Jeptha P Curtis, David Nykanen, Phillip Moore, Lisa Bergersen
Journal: Circulation (2015)

Background: Risk-standardization for adverse events following congenital cardiac catheterization is needed to equitably compare patient outcomes among different hospitals as a foundation for quality improvement. We sought to refine and update the risk-standardization methodology for the NCDR ® IMPACT TM (Improving Pediatric and Adult Congenital Treatment) Registry. Methods: We identified 39,725 consecutive patients within IMPACT undergoing cardiac catheterization between January 2011 and March 2014. New procedure type risk categories were derived by empiric data and expert opinion and markers of hemodynamic vulnerability were empirically explored and identified. A multivariable hierarchical logistic regression model to identify patient and procedural characteristics predictive of a major adverse event (MAE) or death following cardiac catheterization was derived in 70% of the cohort and validated in the remaining 30%. Results: The rate of MAE or death was 7.1% and 7.2% in the derivation and validation cohorts, respectively. Six independent indicators of hemodynamic vulnerability and six procedure-type risk groups were identified. The final risk adjustment model included procedure type risk group, hemodynamic vulnerability, renal insufficiency, single-ventricle physiology, and coagulation disorder (See Figure). The model had good discrimination with a C-statistic of 0.76 and 0.75 in the derivation and validation cohorts, respectively. Model calibration was excellent with a slope of 0.97 (standard error [SE] 0.04; p-value [for difference from 1]= 0.53) and an intercept of 0.007 (SE 0.12; p-value [for difference from 0]= 0.95). Conclusion: We updated and refined a risk-standardization model for outcomes following congenital cardiac catheterization using the large, multicenter IMPACT Registry. Our model can be used for quality reporting back to sites participating in IMPACT to guide quality improvement initiatives.
The Highlands of Medicine
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Literature as an Aid to Restoration
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
COMBINATION STETHOSCOPE
Authors: Myer N. Moss
Journal: JAMA (1924)

The DeLee-Hillis obstetric stethoscope has its value in that it enables the operator, after he is scrubbed and the patient is prepared, to observe closely and follow the fetal heart during the course of the delivery. In addition to this most important feature, it is found that when it is used the heart tones are much louder and more distinct, so that they may be heard much earlier in gestation than with the ordinary stethoscope, and that if they are not heard in the last trimester, the fact gives almost a pathognomic sign of fetal death. This, in part, is due to the fact that the rod leading from the mouthpiece rests on the forehead of the operator, so that the impact of the fetal heart is also transmitted and is felt as well as heard. The combination stethoscope (Fig. 1) is similar to the original head stethoscope, as devised
Histopathology of the Peripheral and Central Nervous Systems.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Risk and Cost of Coronary Angiography
Authors: Charles E. Hansing
Journal: JAMA (1979)

The risk of coronary angiography has been decreasing since development of the procedure 19 years ago. Deaths resulting from angiography now occur only in high-risk clinical circumstances. Whether a certain case load per angiographer or laboratory is necessary for adequate safety is still a question. Even though little available data exist on the relationship of case loads to risk, the National Guidelines for Health Planning now require 300 cardiac catheterizations per laboratory per year and forbid development of new laboratories in hospitals without heart surgery programs. Data collected from all 16 laboratories in Washington showed 26 deaths (0.19%) during 14,050 coronary angiograms. Eighteen of those who died had a severe left main coronary obstruction, and three had severe triple-vessel disease. There were 18 myocardial infarctions (0.13%) and nine strokes (0.06%). The risks in hospitals without cardiac surgery programs and in hospitals performing fewer than 200 cases per year were no higher than in the other hospitals studied. The National Guidelines should be reevaluated before they are used to change the existing pattern of health care. (<i>JAMA</i>242:735-738, 1979)
Eye-strain in Health and Disease.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PERIARTERIAL SYMPATHECTOMY
Authors: ALBERT E. HALSTEAD
Journal: JAMA (1923)

In 1851, Claude Bernard discovered that, when the sympathetic nerve is cut in the neck of a rabbit, the blood vessels in the ear of the same side become very much dilated. He and other observers afterward demonstrated that, if the peripheral (head) end of the severed nerve is stimulated electrically, the ear becomes blanched, owing to a constriction of the blood vessels. Bernard also discovered a second class of nerve fibers, which, when stimulated, caused a dilatation of the blood vessels in the area supplied. The vasoconstrictor nerve fibers belong to the sympathetic autonomic system, consisting, therefore, of a preganglionic fiber arising in the central nervous system and a postganglionic fiber arising from the cell of some sympathetic ganglion. These nerves form plexuses in the media of arteries and terminate in contact with the muscle fibers. While the terminations of the nerves are in the media, the adventitia, or
A7.3 The mucosal anti-citrullinated protein antibody response in pre-clinical rheumatoid arthritis
Authors: A Van der Horst, YK Choi, DJ van Schaardenburg, DM Gerlag, D Hamann, PP Tak, RM Thurlings
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Recent data suggest rheumatoid arthritis (RA) may originate from an autoimmune response in inflamed mucosa. When aiming to prevent arthritis it is critical to understand the source and regulation of autoantibody production in preclinical RA. <h3>Objective</h3> To determine whether ACPA are produced at mucosal sites in ACPA positive individuals at risk for RA and to compare the ACPA isotype and fine specificity in mucosal fluids to peripheral blood. <h3>Materials</h3> Saliva, sputum, faeces and peripheral blood were collected during an early morning visit from 15 individuals with anti-cyclic cit protein (anti-CCP2) antibody positive arthralgia who are part of a cohort that is being prospectively followed for the possible development of arthritis. Sputum was induced by inhalation of sodium chloride aerosols 4.5%. Mucus plugs were selected from sputum for extraction of supernatants. IgG and IgA ACPA were measured in mucosal fluids and blood using two cit fibrinogen peptides, one enolase peptide and one vimentin peptide and their arginine peptides as control. <h3>Results</h3> Eleven of 15 individuals tested positive for anti-CCP2 and ACPA in their blood at the day of mucosal fluid collection. Four patients tested positive for anti-CCP2 but negative for the tested ACPA. IgG Anti-cit fibrinogen, enolase and vimentin antibodies were detected in respectively 11, 4 and 3 individuals. In 3 individuals IgA anti-cit fibrinogen and anti-cit vimentin antibodies were present. The saliva of 5 patients contained ACPA with IgA anti-cit enolase and anti-cit fibrinogen in 4 patients and IgG anti-cit enolase and anti-cit fibrinogen in 2 patients. The sputum of one patient contained IgA anti-cit-fibrinogen. Other samples tested negative for ACPA. There were no differences in ACPA number or type in blood between patients with or without mucosal ACPA. All 5 patients with ACPA in saliva had the same antibodies in blood, in 4 of 5 individuals only of IgG class. In 2 of 5 patients ACPA were detected in blood that were not detected in saliva. <h3>Conclusion</h3> Collection of saliva, sputum and faeces allows for the detection of ACPA in the mucosal secretions of a proportion of anti-CCP positive individuals at risk for RA. In these patients, ACPA in blood are predominantly of the IgG class and in some patients directed against more peptides compared to ACPA in secretions. Future analyses should focus on further defining the precise source and regulation of mucosal and systemic ACPA.
LETTER FROM LONDON.
Journal: JAMA (1889)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sudden Infant Death Syndrome: Will Establishing Risk Factors Spuriously Reduce Incidence?-Reply
Authors: Warren Guntheroth
Journal: JAMA (1993)

<h3>In Reply.</h3> —We appreciate the concerns of Hanzlick et al about the effects of reports such as ours on diagnosing and certifying SIDS as a cause of death. In particular, they are concerned that medical examiners will use sleep position as a criterion for certification of SIDS, which could result in the use of alternate diagnostic categories and a spurious decline in SIDS. We agree that reports of a decline in SIDS rates attributed to public interventions should include assurances that there were no increases in alternate diagnostic categories for sudden and unexpected infant deaths. In our study of the metropolitan area of Seattle, Wash,<sup>1</sup>we found a substantial decline in SIDS deaths with no increase in aspiration, asphyxiation, or unknown categories. Neither we nor any of the reports that we cited have suggested that sleep position be a criterion for the diagnosis of SIDS. That suggestion could be
Sulfobromophthalein
Authors: R. M. Charm
Journal: JAMA (1967)

The sodium sulfobromophthalein (Bromsulphalein) test (BSP) in the nonjaundiced patient remains today as one of the best and most sensitive indicators of liver dysfunction. It is not, however, useful in the differential diagnosis of jaundice since bilirubin competes with the dye for removal by the liver. When the dye is injected intravenously, most of it is taken up by the liver cells, stored, conjugated, and finally excreted in the bile. An abnormal retention of sulfobromophthalein represents, therefore, a disturbance of one or more of these functions. A decreased blood flow to the liver will also lead to an increased retention of the dye. An insignificant quantity of the sulfobromophthalein is absorbed from the small intestine and transported back to the liver—the so-called enterohepatic circulation. The technique is as follows: 5 mg of dye per kilogram of body weight is injected intravenously. In the calculation of the number of cubic centimeters
Osteoporosis
Authors: Kristine E. Ensrud, Carolyn J. Crandall
Journal: Annals of Internal Medicine (2017)

This article has been corrected. The original version (PDF) is appended to this article as a Supplement. Osteoporosis is a common systemic skeletal disorder resulting in bone fragility and increased fracture risk. However, management of osteoporosis and fracture prevention strategies are often not addressed by primary care clinicians, even in older patients with recent fractures. Evidence-based screening strategies will improve identification of patients who are most likely to benefit from drug treatment to prevent fracture. In addition, careful consideration of when pharmacotherapy should be started and choice of medication and duration of treatment will maximize the benefits of fracture prevention while minimizing potential harms of long-term drug exposure.