tbuckley/cabot-search huggingface dataset:
LESSONS OF THE EPIDEMIC AT ITHACA.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Randomized Phase III Trial of Melphalan and Dexamethasone (MDex) Versus Bortezomib, Melphalan and Dexamethasone (BMDex) for Untreated Patients with AL Amyloidosis
Authors: Efstathios Kastritis, Xavier Leleu, Bertrand Arnulf, Elena Zamagni, Peter Mollee, M Teresa Cibeira, Stefan O Schönland, Philippe Moreau, Roman Hajek, Arnaud Jaccard, Emmanuelle Nicolas-Virelizier, Robin Filshie, Bradley Augustson, Maria-Victoria Mateos, Paolo Milani, Meletios A. Dimopoulos, Eric Hachulla, Jean-Paul Fermand, Andrea Foli, Antonio Palumbo, Pieter Sonneveld, Hans Erik Johnsen, Giampaolo Merlini, Giovanni Palladini
Journal: Blood (2014)
Selected Abstracts
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dec 1 designated World AIDS Day: message is 'Join the Worldwide Effort'
Authors: M. F. Goldsmith
Journal: JAMA (1988)

CHEFS IN PARIS are planning to cook a special dinner and donate the proceeds to the cause. King Taufa'ahau Tupou IV will speak over the radio to his subjects on the Pacific Ocean island of Tonga. A choir organized by Varig Airlines will sing at the airport in São Paulo, Brazil; logo-bearing T-shirts will be sold on the beach in the Seychelles; and a condom show will be presented in Bangkok. These activities and hundreds more, launched under the sponsorship of the World Health Organization's (WHO) Global Programme on AIDS (GPA), will start today and culminate on Dec 1 in World AIDS Day. To focus attention on the universal war under way against acquired immunodeficiency syndrome and infection with human immunodeficiency virus, the GPA began in June to encourage governments and communities as well as groups and individuals to plan events with the themes "Let's talk about AIDS," "Join the
Error in Data
Authors: Ivaylo Stoilov, Anne Fung, Roman Rubio, Jody Zylke
Journal: JAMA (2014)

Jeffrey M. Rohde, MD; Derek E. Dimcheff, MD, PhD; Neil Blumberg, MD; Sanjay Saint, MD, MPH; Kenneth M. Langa, MD, PhD; Latoya Kuhn, MPH; Andrew Hickner, MSI; Mary A. M. Rogers, PhD
A System of Obstetrics.
Journal: JAMA (1889)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PTH-019 Mortality from acute upper gastro-intestinal bleeding in the UK: does it display a “weekend effect”?
Authors: V Jairath, R Logan, S Hearnshaw, S Travis, M Murphy, K Palmer
Journal: Gut (2010)

<h3>Introduction</h3> A number of medical and surgical conditions demonstrate an association between presentation to hospital at the weekend and increased mortality. Potential reasons for this “weekend effect” include reduced staffing levels and a lower likelihood to undergo invasive procedures. Acute Upper Gastrointestinal Bleeding (AUGIB) is an ideal condition to examine weekend/weekday mortality as it has a substantial mortality (10%) and may require early access to upper endoscopy to achieve haemostasis. A recent UK nationwide audit of patients admitted with AUGIB revealed that the majority of AUGIB patients (59%) present out of hours and only half of UK hospitals have a formal out-of-hours endoscopy service.1 <h3>Methods</h3> To analyse whether weekend presentations for AUGIB have a higher mortality compared with those patients presenting on weekdays. Further analyses were performed on patients included in the 2007 UK Comparative Audit of Upper Gastrointestinal Bleeding and the Use of Blood.1 Weekend presentation was defined as any patient presenting between midnight on Friday through to midnight on Sunday. <h3>Results</h3> Data were analysed on 6750 patients across 208 UK hospitals, including both new admissions with AUGIB (5550/6750) and existing in-patients (1107/6750). Patient characteristics were comparable with no significant difference between mean Rockall score at presentation, mean number of comorbidities, receipt of red cell transfusion, therapeutic endoscopy for actively bleeding lesions, length of hospital stay and surgery. The only notable difference was that a significantly smaller percentage of patients were endoscoped either within 12 or 24 h on the weekend. Despite this delay to earlier endoscopy there was no significant difference in mortality between patients presenting on the weekend (9.9%) or during the weekdays (10%). Subanalysis of new admissions only similarly showed no difference in mortality for weekend (7%, 86/1228) vs weekday (6.8%, 293/4321) presentation. <h3>Conclusion</h3> In this large nationwide UK audit, we found no overall difference in mortality in patients presenting with AUGIB on weekends as compared with those presenting on weekdays. This is despite delay to early endoscopy on weekends, a large proportion of hospitals without out-of-hours endoscopy services, and other likely organisational factors on weekends including reduced staffing patterns of physicians, nurses and other support staff.
Manuel d'urétroscopie.
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Counseling about physical activity
Authors: Neil M. Resnick, Susan L. Greenspan
Journal: JAMA (1989)

<h3>To the Editor.—</h3> We enjoyed the recent<i>JAMA</i>article on exercise,<sup>1</sup>but feel that the evidence supporting its preventive role in postmenopausal osteoporosis is less convincing than implied. Since the conclusions seem to be influenced by one study in particular,<sup>2,3</sup>it might be useful to examine it in more detail. Although the methods section is unclear, the study cited does not appear to be a randomized study of exercise<sup>4</sup>; patients seemed to volunteer to exercise and then were randomized to receive medication or a placebo, making selection bias likely. The bias may well have continued, because results were provided only for those 62% of subjects able to participate for 3 years. Moreover, the exercises included arm lifts and pulling wheelchairs, with the only reported end point being densitometric measurements of the forearm. No evidence was provided or can be inferred regarding the effect of such exercise on
Mass screens for sickel cell disease
Authors: R. E. Bernstein
Journal: JAMA (1973)

<h3>To the Editor.—</h3> The EDITORIAL by Nalbandian (221:500, 1972) on the consequences of the passage of the National Sickle Cell Anemia Control Act calls for some comment and qualification—both with regard to the screening program introduced by the Grand Rapids group in its general applicability to the United States and to other parts of the world, where sickle hemoglobin attains notable incidences. The sickle cell phenomenon is not exclusive to 22 million black Americans; not only are there higher incidences among the Negroes of central equatorial Africa, the west coast bulge of Africa, the West Indies, and adjacent areas of South America, but sickle cell hemoglobin occurs to a variable, but often significant degree in non-Negroid groups, ie, Greeks, Italians, Sardinians, Turks, Libyans, and Tunisians of the Mediterranean regions, as well as inhabitants of South Arabia, Southeast Asia, India, Malagasy (originally Indonesian in origin, but with some Negroid admixture from
Are complications of endoscopic sphincterotomy age related?
Authors: M H THOMPSON
Journal: Gut (1998)

Editor,—Deans et al ( Gut 1997; 41 :545–8) have supported the use of endoscopic sphincterotomy for bile duct stones in young people in preference to laparoscopic bile duct exploration. They do this because sphincterotomy causes no more complications in young than in old people. Any comparison between the two methods must also take into account the complications, particularly pancreatitis, that occurred in the remaining two-thirds of the patients undergoing endoscopic retrograde cholangiopancreatography (ERCP) without sphincterotomy. Laparoscopic duct exploration is still a relatively new technique. Rhodes et al reported 129 explorations with one case of postoperative pancreatitis.1 We have had no pancreatitis in 53 explorations. Until larger series are reported judgement is impossible. For the treatment of bile duct stones a comparison of therapeutic success and the manoeuvres required to achieve it are required on an intention-to-treat basis. The consequences of sphincterotomy and reflux in the very long term are not known. Most bile duct stones are predominantly composed of pigment, thought to be … Mr Deans.
Parents for the parentless.
Journal: BMJ (1971)

fully sensitive to either of these antibiotics, and a suitable one should be chosen on the basis of tests applied to a cultuie of saliva from each patient.On the other hand Paterson and Madden7 report encouraging findings for erythromycin; 45 out of 53 penicillin-resistant strains were not merely inhibited but killed by only 0-35 l.g/ml and all but 3 of the rest by concentrations little higher.Moreover, serum from patients 1 hours after receiving 500 mg of erythromycin estolate was bactericidal for such streptococci when diluted 1 in 10.Acceptance of these findings would piovide much the simplest answer to this problem.If this method is adopted it is important that the estolate of erythromycin should be used.In other forms this antibiotic is not so reliably absorbed, and the only objection to the estolate, the risk of hepatitis, is immaterial when only two or three doses need be given.
MICROBIC DISSOCIATION
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Proceedings of the Thoracic Society
Journal: Thorax (1966)

LUNG BIOPSIESM. TURNER-WARWICK said that lung biopsies from patients with interstitial pulmonary fibrosis had been studied by immuno-fluorescent techniques to identify tissue-fixed immuno-globulins using conjugated anti- human Ig G, Ig A, and Ig M and anti-Bic (anti- complement).Various types of extracellular and intracellular fluorescence had been observed in seven out of eight specimens examined; these were described and their significance was discussed, comparing them with five biopsies taken from patients with other pulmonary disease.Intracellular fluorescence was particularly prominent in plasma cells and certain macrophages using Ig A. Extracellular fluorescence was seen in relation to germinal follicles using Ig G and Ig M. In three cases of special interest bright fluorescence of the alveolar wall was seen using conjugated anti- complement suggesting intramural deposition of antigen/antibody complexes. UNUSUAL ASPECTS OF BRONCHIAL CARCINOMAH. SPENCER (introduced by N. R. BARRETT) dis- cussed some problems raised by three forms of lung cancer, the nature of 'giant-cell' carcinoma, the origin of 'oat-cell' lung cancer, and the nature of pulmonary blastomas, and their importance in connexion with the embryology of the lung.A rare variant type of lung cancer, the giant-cell carcinoma, was briefly presented.The active phago- cytic activity shown by the tumour cells and the occasional occurrence of haemolytic anaemia in this disease cast some doubt on the nature of this tumour, and raised the possibility that it may be a form of pulmonary sarcoma.The origin of 'oat-cell' carcinoma cannot yet be regarded as by any means settled, and the view is advanced, based on macroscopic, microscopic, electron
Birth defects
Authors: Lester S. King
Journal: JAMA (1963)

In recent years the interest in birth defects has become broader and deeper. Yet, as Dr. Apgar points out in her brief preface, although much has been written for the physicians, for the people most concerned—the parents, relatives, and friends—not much is available in the way of explanation. Regarding these laymen: "There are all too few places to which to turn for a better understanding of what went wrong and why. It is hoped that this book will fill their need, in terms and language they use themselves, and so help them to bring the life of each child to its greatest fulfillment." In only 318 text pages, 30 authorities provide 30 chapters which cover such diverse and complex topics as cell structure, embryology, chromosomes and genes, DNA, radiation hazards, the effect of viruses, inborn errors of metabolism, erythroblastosis, numerous specific congenital anomalies—to name only a few. Unfortunately, while some
Cryotherapy for oral cancer
Authors: A. A. Gage
Journal: JAMA (1968)

Freezing with liquid nitrogen was used for treatment of oral and oropharyngeal cancers in 50 patients. Reasons for the choice of cryotherapy included resistance to radiotherapy, location in areas difficult to excise, desire to avoid disabling sacrifice of mandible or palate, and presence of severe cardiopulmonary disease. The technique was well suited to oral cancer because of its accessibility to treatment and observation. In terms of survival, results appeared comparable to those of excision. Of 24 patients treated more than a year ago, failure to control the primary lesion occurred in three, all of whom had large oropharyngeal lesions not considered suitable for excision. Some of the remaining 21 have died of heart disease or metastatic cancer, but more (17) are alive and apparently well.
Consideration of height-based rather than weight-based dosing as a more appropriate method of treating with radium-223.
Authors: Thomas Andrew Longo, Luke T. Nordquist, Samuel H. Mehr, Matthew McDonald
Journal: Journal of Clinical Oncology (2014)

e16075 Background: Radium 223 is approved for use in patients with symptomatic bone metastasis from castrate resistant prostate cancer. It is currently dosed in a weight based fashion, however it is only active in the skeleton, and it is distributed primarily to the bone. It is then excreted by the intestines. Our study looks at the safety profile and efficacy of radium 223 in the context of a height based dosing regimen. Methods: This is a retrospective, observational study of all patients receiving radium 223 at the Urology Cancer Center. As of January 2014 40 patients received a total of 178 doses of RAD-223 at our site. All patients received the FDA approved dose of 50 kBq/kg. The dose each patient received was then re-calculated based upon the patient’s height. The medical record was then examined for reported toxicities and the patient’s response to a pain scale after each dose. Results: The lowest dose based on height administered was 17.39 kBq/cm and the highest dose was 40.7 kBq/cm with an average dose of 27.4 kBq/cm. The side effect profile did not show any trends across the different levels of dosing regarding the number or grade of toxicity. Grade 1 nausea was experienced by 25% of the patients and 10% had grade 2 nausea. Diarrhea was experienced by 33% of the patients; 6 of the 11 patients with diarrhea had a prior history of pelvic radiation. Anemia was experienced by roughly 20% of the patients; most hematologic toxicities were reported prior to initiating RAD-223 and remained stable. When the pre- and post-treatment pain scale was examined, patients with a BMI≥28 experienced an average 2 point reduction, while those with a BMI≤27 had only an average 0.2 reduction in their pain scale. Conclusions: A height based dosing regimen may be more appropriate for a drug designed to treat only the skeleton. In our population, we administered a wide variety of doses when examined by height. Higher doses appear to be well tolerated, and the optimal dose has yet to be determined. The EMR confirmed that nearly every patient experienced relief of pain after starting therapy based on pre- and post-treatment pain scales. We propose future studies with height-based dosing escalation to look at the safety and efficacy.
PP-017 The effect of salivary nitrite on gastro-oesophageal reflux
Authors: J P Seenan, A A Wirz, A T Clarke, J J Manning, V Fyfe, A W Kelman, K E L McColl
Journal: Gut (2010)

<h3>Introduction</h3> Human saliva has a high nitrite concentration from the entero-salivary recirculation of dietary nitrate. Swallowed nitrite reacts with gastric acid to form nitric oxide (NO) at the gastro-oesophageal junction. This may contribute to the pathogenesis of reflux disease. NO has been shown to reduce lower oesophageal sphincter (LOS) pressure, impair oesophageal clearance and may be the final mediator in the production of transient lower oesophageal sphincter relaxations (TLOSRs). <h3>Aims</h3> To determine (1) whether nitrite in saliva increases oesophageal acid exposure and (2) whether nitrite in swallowed saliva modifies the manometric characteristics of the LOS and distal oesophagus. <h3>Methods</h3> 20 asymptomatic subjects (11 males) were studied. Each underwent endoscopy to document normal anatomy. On four separate days, high-resolution manometry and pH were performed during 15 min fasting and for 90 min following a standardised meal. Postprandially, solutions containing 0, 0.286, 2 and 14 mmol/l potassium nitrite were infused into the oral cavity. Solutions were randomised and double-blinded. Saliva was collected at baseline, 30, 60 and 90 min following the meal. Nitrite concentrations were quantified by Griess reaction. Acid exposure was calculated as per cent time pH&lt;4. The number of reflux events was calculated and reflux event characteristics (duration and nadir pH) recorded. TLOSRs were determined using established criteria. Mean LOS pressure, peristaltic wave velocity and peristaltic amplitude were also calculated. To adjust for multiple comparisons the Bonferroni method was used with p&lt;0.017 considered significant. Results are medians and ranges unless stated. <h3>Results</h3> Salivary nitrite concentrations at 60 min were 24.35 μmol/l (3.86–65.46), 80.42 μmol/l (20.88–158.79), 358.4 μmol/l (118.2–726.6) and 2694 μmol/l (600–8087) for the solutions containing 0, 0.286, 2 and 14 mmol/l nitrite, respectively. There was no difference in acid exposure between the control and the nitrite-containing solutions (p&gt;0.04). There was no difference in the number (p&gt;0.05), duration (p&gt;0.4) or nadir pH (p&gt;0.2) of reflux events. The mean number of TLOSRs and the reduction in postprandial LOS pressure were similar (p&gt;0.04 and p&gt;0.07). There was no difference in peristaltic wave velocity or amplitude (p&gt;0.1 and p&gt;0.6). <h3>Conclusion</h3> Despite an excellent range of salivary nitrite concentrations, over and beyond the normal physiological range, no difference in oesophageal acid exposure or oesophageal motility was seen between the control solution and those containing nitrite. These findings suggest that salivary nitrite does not potentiate oesophageal reflux.