tbuckley/cabot-search huggingface dataset:
Competition and cost in graduate medical education. Should we train unsalaried residents and fellows?
Authors: M. P. Leeds
Journal: JAMA (1985)

In 1985, a total of 6,080 applicants to the National Resident Matching Program (Match) were unable to match with residency positions. The majority of unmatched applicants were graduates of foreign medical schools. In addition, many US and foreign medical graduate applicants did not find positions in their preferred choice of specialties. As a result, teaching hospitals are increasingly receiving offers from would-be residents who are willing to work without financial support to gain the experience and credentials required for medical licensure. Teaching hospitals that consider accepting unsalaried house staff must begin to develop policies and guidelines that ensure fair and equitable treatment of all residents and fellows and that standards of quality are not compromised. (<i>JAMA</i>1985;254:2787-2789)
Psychopharmacology
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Editorial_Board
Authors: Harvey Risch, Edward Sausville, Richard Schilsky, Arnold Schwartz, Mark Sherman, Robert Shoemaker, Richard Simon, Margaret Spitz, Ian Tannock, Joel Tepper, Giovanna Tosato, Sally Vernon, Douglas Weed, K Yabroff, Regina Ziegler, Adriana Albini, Wendy Atkin, Mariano Barbacid, Stacey Berg, Russell Berman, William Blot, Peter Blumberg, John Boice, A Louise, George Brinton, Martin Browman, Ethan Brown, Ross Dmitrovsky, Susan Donehower, Joann Ellenberg, Michele Elmore, Ellen Evans, Elizabeth Feigal, Mitchell Fox, Patricia Gail, Ann Ganz, Edward Geiger, Paul Giovannucci, John Godley, Michael Gohagan, Peter Gottesman, Kathy Greenwald, Donald Helzlsouer, Arti Henson, John Hurria, Jean-Pierre Ioannidis, Colin Issa, Lisa Jefcoate, Frederic Kachnic, Bernard Kaye, Isra Levin, W Levy, Marc Linehan, Scott Lippman, Dan Lippman, Douglas Longo, Elena Lowy María, Joseph Martínez, Joseph Mclaughlin, Mads Gordon Mcvie, Ugo Melbye, Alan Pastorino, David Rabson, Christopher Amos, Janet Andersen, Stuart Baker, Roula Barhoumi, Jacques Benichou, Donald Berry, Jinbo Chen, Timothy Church, Bernard Cole, Kathleen Cronin, Susan Ellenberg, Ruth Etzioni, Richard Fagerstrom, Mary Foulkes, Barry Graubard, Susan Groshen, Michael Hauptmann, Daniel Heitjan, Li Hsu, Hormuzd Katki, Victor Kipnis, Edward Korn, J Lee, Martin Mcintosh, Margaret Pepe, Ruth Pfeiffer, Philip Prorok, Philip Rosenberg, Larry Rubinstein, Mark Segal, Steven Skates, Donald Stablein, Sholom Wacholder, Kai Yu, Hans-Olov Adami, Harry Burke, Pelayo Correa, Soldano Ferrone, Isaiah Fidler, Curtis Harris, Emily Harris, Maureen Henderson, Gloria Heppner, Allan Hildesheim, Waun Hong, William Hoskins, Peter Houghton, David Johnson, V Craig, Jordan Ilan, R Kirsch, Kenneth Kraemer, Alexandra Levine, Martha Linet, Henry Lynch, Pamela Marcus, Frank Meyskens, Anthony Miller, Malcolm Mitchell, David Page, Kenneth Pienta, David Schottenfeld, Richard Severson, Jerry Shay, Debra Silverman, Sandra Swain, G Swanson, Mario Sznol, Raymond Taetle, Barnett Kramer, Frederic Kaye, Douglas Weed Reviews, Martin Brown, Carmen Allegra, Patricia Ganz, Frederic Deputy, William Barlow, Paul Frankel, Lisa Kachnic, Bernard Levin, Isra Levy, W Linehan, Marc Lippman, Dan Longo, Douglas Lowy María, Elena Martínez, J Gordon Mcvie, Mads Melbye, Ugo Pastorino, Alan Rabson, David Ransohoff, Stephen Brown, Ethan Chanock, Manel Elmore, Elizabeth Esteller, Harvey Jefcoate, Edward Risch, Arnold Sausville, Mark Schwartz, Robert Sherman, Richard Shoemaker, Margaret Simon, Ian Spitz, Joel Tannock, Giovanna Tepper, Sally Tosato, Douglas Vernon, K Weed, Regina Yabroff, Larry Ziegler, Mark Rubinstein, Richard Segal, Steven Simon, Donald Skates, Sholom Stablein, Greg Wacholder, Kai Yothers, Jeannine Botos, Senior Editors, Amanda Boehm, Sharmistha Ghosh-Janjigian, Beatrice Grabowski, Ann Pluta, Susan Spence, Meredith Abel, Tyler Lowry, Mandy Byrdic, Kathleen Hurst, Kristine Crane, Zachary Rathner, Vicki Brower, Mike Fillon, Ken Garber, Marie Gethins, Merrill Goozner, Karyn Hede, Norra Macready, Alison Palkhivala, Charles Schmidt, Rabiya Tuma, Jeannine Botos Senior
Journal: JNCI Journal of the National Cancer Institute (2012)
The Auto in Winter.
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Food allergy
Authors: R. H. Buckley
Journal: JAMA (1982)

FOOD ALLERGY is widely perceived by the public as a major health problem. Although the true incidence of food allergy is unknown, it is probably much less common than thought. Its incidence among children has been variously estimated from 0.3% to 7.5%, and the incidence decreases with age. Acute allergic reactions to foods which are clearly IgE mediated can, however, develop in adults who previously tolerated foods with impunity. Clinically, food-induced reactions of the immediate hypersensitivity type are well documented and include urticaria, angioedema, and anaphylaxis. Reactions to foods mediated through cytotoxic, antigen-antibody-complex and delayed hypersensitivity mechanisms remain to be clearly demonstrated except in gluten-induced enteropathy, where immunoglobulin and complement deposition has been noted. <h3>CLINICAL FEATURES</h3> Immunologically mediated reactions to foods are expressed clinically by a diversity of signs and symptoms from abdominal pain to generalized anaphylaxis. These clinical expressions of food allergy are influenced by factors including the age
BOOKS RECEIVED.
Journal: British Journal of Dermatology (1922)

A Treatise on Diseases of the Skin for Advanced Students and Practitioners. By H. W. Stelwagon. M.D., Ph.D., Late Professor of Dermatology in the Jefferson pp. 1313. 401 Text Illustrations, 29 Coloured and Half‐tone Plates. Loudon: W.B. Saunders & Co. Ltd., 1921. Price 50s. net.
Experimental Studies on the Effects of Sympathetic Nerve Stimulation and Catecholamines on Cardiac Activity
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
25-Hydroxyvitamin D, Insulin-Like Growth Factor-I, and Bone Mineral Accrual during Growth
Authors: M. E. Breen, E. M. Laing, D. B. Hall, D. B. Hausman, R. G. Taylor, C. M. Isales, K. H. Ding, N. K. Pollock, M. W. Hamrick, C. A. Baile, R. D. Lewis
Journal: Endocrine Reviews (2010)

ContextThe extent to which 25-hydroxyvitamin D [25(OH)D] and IGF-I influence bone mineral content (BMC) accrual from early to mid-puberty is unclear.
Abstract 12430: Vicious Circle Between Progressive Right Ventricular Dilatation and Pulmonary Regurgitation in Patients After Tetralogy of Fallot Repair? Right Heart Enlargement Promotes Flow Reversal in the Left Pulmonary Artery
Authors: Atsuko Kato, Christian Drolet, Shi-Joon Yoo, Andrew Redington, Lars Grosse-Wortmann
Journal: Circulation (2015)

Introduction: The left pulmonary artery (LPA) contributes more than the right (RPA) to total pulmonary regurgitation (PR) in patients after tetralogy of Fallot (TOF) repair, but the mechanism of this difference is not well known. We hypothesized that unilaterally increased pulmonary vascular resistance (PVR), resulting from lung compression by the enlarged and levorotated heart leads to greater PR in the LPA. This study aimed to analyze the interplay between heart and lung size, mediastinal geometry, and differential PR. Methods: This is a single-center retrospective analysis of 50 magnetic resonance studies in patients after TOF repair. Patients with more than mild discrete branch pulmonary artery stenosis were excluded. Blood flow was measured by phase-contrast velocity encoding within the branch pulmonary arteries. On the axial image with the largest total cardiac surface area, cardiac angle (α) between the thoracic anterior-posterior line and the interventricular septum, right and left lung areas as well as right and left hemithorax areas were measured (Figure). Results: There was no difference in LPA and RPA diameters. The LPA showed significantly less total forward flow (p=0.04), smaller net forward flow (p=&lt;0.001), and greater RF (p=0.001) than the RPA. Left lung area was smaller than the right (p&lt;0.001). RVEDVi correlated with LPA RF (R=0.48, p&lt;0.001), but not with RPA RF. Larger RVEDVi correlated with a larger α angle (R=0.46, p&lt;0.001), i.e. a more leftward cardiac axis and with smaller left lung area (R=-0.58, p&lt;0.001). LPA RF, but not RPA RF, correlated inversely with left lung area indexed to the left hemithorax area (R=-0.34, p=0.02). Conclusions: An enlarged and levorotated heart - as a result of PR - is associated with smaller left lung size, and augments diastolic flow reversal in the LPA, presumably via increased left PVR. By imposing a further volume load on the RV, LPA regurgitation may thus close a positive feed-back loop of PR and RV dilatation.
Selection
Authors: A. Paton
Journal: BMJ (1995)

Cyclin-dependent kinase 5 (Cdk5) and its activator p35 have been implicated in drug addiction, neurodegenerative diseases such as Alzheimer9s, learning and memory, and synapse maturation and plasticity. However, the molecular mechanisms by which Cdk5 regulates synaptic plasticity are still unclear. PSD-95 is a major postsynaptic scaffolding protein of glutamatergic synapses that regulates synaptic strength and plasticity. PSD-95 is ubiquitinated by the ubiquitin E3 ligase Mdm2, and rapid and transient PSD-95 ubiquitination has been implicated in NMDA receptor-induced AMPA receptor endocytosis. Here we demonstrate that genetic or pharmacological reduction of Cdk5 activity increases the interaction of Mdm2 with PSD-95 and enhances PSD-95 ubiquitination without affecting PSD-95 protein levels <i>in vivo</i> in mice, suggesting a nonproteolytic function of ubiquitinated PSD-95 at synapses. We show that PSD-95 ubiquitination correlates with increased interaction with β-adaptin, a subunit of the clathrin adaptor protein complex AP-2. This interaction is increased by genetic reduction of Cdk5 activity or NMDA receptor stimulation and is dependent on Mdm2. Together these results support a function for Cdk5 in regulating PSD-95 ubiquitination and its interaction with AP-2 and suggest a mechanism by which PSD-95 may regulate NMDA receptor-induced AMPA receptor endocytosis.
The AP-1 Transcription Factor JunB Promotes Multiple Myeloma (MM) Cell Proliferation, Survival and Drug Resistance in the Bone Marrow Microenvironment
Authors: Fengjuan Fan, Sonia Vallet, Martin Sattler, Giovanni Tonon, Muhammad Hasan Bashari, Latifa Bakiri, Hartmut Goldschmidt, Erwin F. Wagner, Dirk Jaeger, Klaus Podar
Journal: Blood (2014)
Doctor's pay.
Journal: BMJ (1981)

it is first given to volunteers. 2 14 The drawback with all approaches made is that they have been based on the use of complex organisms and not pure antigens.Other than one parasite protein that has been found to protect ducks against P lophurae,') few data are available from research in vivo to indicate whether single antigens could be of value.Fortunately, attention is now being directed to the use of monoclonal antibodies to identify immunogenic antigens in malaria parasites, and several have recently been described both in rodent parasites'6 and in P falciparum."7Future efforts will probably be focused on the application of this new technology and the production of protective sporozoite or merozoite antigens by DNA recombinant procedures.Indeed, this is the most likely route to a practical vaccine for use in man.There is, however, a long way to go, and we should be deceiving our- selves if we believed that a vaccine was, as some have suggested, just round the corner.It would also be a great mistake to assume that malaria will ever be controlled in whole populations (as distinct from individuals) by any single measure.Control programmes need to take into account the best available antivector measures, drugs, vaccines (including, perhaps, an antigamete component to interrupt further transmission'8), and health education tailor made for any given area.The biggest need may still be for well-trained malariolo- gists.
The relation between hospital experience and in-hospital mortality for patients with AIDS-related PCP
Authors: C. L. Bennett
Journal: JAMA (1989)

There is marked debate by physicians and policymakers regarding the creation of regionalized acquired immunodeficiency syndrome (AIDS) centers. A central issue is whether outcomes of care, particularly mortality, differ as a function of hospital experience with patients with AIDS. We evaluated the experience of 257 patients with AIDS and<i>Pneumocystis carinii</i>pneumonia treated at 15 California hospitals between October 1986 and October 1987. An overall 15.2% in-hospital mortality rate was observed. However, a markedly lower in-hospital mortality rate was observed in the group of patients treated at hospitals that had a high level of experience with patients with AIDS (≥30 human immunodeficiency virus-related discharges per 10 000 hospital discharges) relative to the group treated at hospitals with less experience (&lt;30 human immunodeficiency virus-related discharges per 10 000 hospital discharges): 12% vs 33%. Other factors significantly associated with in-hospital mortality included intensive care unit use, admission from an emergency department or through an interhospital transfer, and a history of hospitalizations. A logistic regression model indicated that, after controlling for severity indicators, AIDS experience remained significantly related to mortality. Our findings suggest that policymakers should consider three options: creating regional AIDS centers, implementing policies that promote a rapid but carefully monitored increase in experience of low-volume hospitals with human immunodeficiency virus-infected individuals, or providing highly focused educational efforts at low—AIDS-experience facilities. Without such policy initiatives, differences in mortality rates like those we have found might persist as cases of AIDS begin to occur in every area of the country. (<i>JAMA</i>1989;261:2975-2979)
The Uninsured
Authors: Emily Friedman
Journal: JAMA (1991)

SOME health policy issues are like bad pennies; despite repeated efforts to resolve them, they keep coming back. Probably no health policy issue of this century (with the possible exception of insuring and structuring long-term care, which affects far fewer people) has proven as intractable as access to acute care for Americans who lack coverage for the cost of that care. It was a problem for most Americans at one time; after the introduction of private insurance early in the 20th century, it became a problem more of specific groups, notably the elderly and the poor. Coverage of those who were uninsured was a policy centerpiece (largely unrealized) of President Harry S Truman's administration. With the passage of Medicaid and Medicare in 1965, it was thought the issue was largely resolved. The uninsured, however, like the proverbial poor, seem always to be with us. In fact, their numbers have grown
Anaplasia Rediviva
Authors: PETER MEDAWAR
Journal: Annals of Internal Medicine (1977)

Anaplasia refers to the apparent retrogression toward an embryonic state that occurs in some human and animal tumors, the consequence, presumably, of a derepression of genes that would normally have been switched off in the course of development. The fetal substances newly formed in tumors are identified immunologically and are therefore referred to as "antigens." Some such antigens, for example, carcinoembryonic antigen and alpha-fetoprotein, and blood-group precursor substances have great promise diagnostically but play no known part in resistance to malignant growth. The reawakened fetal antigens that are of special interest and importance are those that are capable of arousing cell-mediated immunity and thus may contribute to antitumor immunity. Modern research, therefore, rehabilitates an etiologc notion earlier thought to have been discredited.
Patterns of Organization in the Central Nervous System: Proceedings of The Association, December 15 and 16, 1950, New York, N. Y. Research Publications, Association for Research in Nervous and Mental Diseases, Volume XXX.
Journal: JAMA (1952)

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PLACENTAL PERMEABILITY
Authors: K SOIVA
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Just Words
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal