tbuckley/cabot-search huggingface dataset:
Lead Alters the Immunogenicity of Two Neural Proteins: A Potential Mechanism for the Progression of Lead-Induced Neurotoxicity
Authors: Stacey J. Waterman, Hassan A. N. El-Fawal, Carroll A. Snyder
Journal: Environmental Health Perspectives (1994)

Some heavy metals have been suspected of playing a role in the pathogenesis of nervous system diseases such as multiple sclerosis, amyotrophic lateral sclerosis, and Alzheimer's disease. In these disorders, autoantibodies against neural proteins are evident at some stage of the disease. Lead is known to affect both the immune and nervous systems. Work in our laboratory has shown that lead exposure leads to the production of autoantibodies against neural proteins, including myelin basic protein (MBP) and glial fibrillary acidic protein (GFAP). We hypothesize that lead aggravates neurological disease by enhancing the immunogenicity of nervous system proteins, including MBP and GFAP. To test this hypothesis, lead-altered protein was prepared by incubating MBP or GFAP with lead acetate for 24 hr. On days 0, 14, and 28, mice received inoculations with either saline, native protein, or lead-altered protein. Anti-MBP and anti-GFAP, isotypes IgM and IgG, were measured in sera by ELISA on day 38. Sera of mice treated with lead-altered MBP had statistically higher anti-MBP IgG titers than both control and native MBP-immunized mice. An analogous response was seen in mice immunized with lead-altered GFAP. Supernatants from lectin-stimulated splenocytes were also examined for antibody titers and for interleukin 2 (IL-2) and interleukin 6 (IL-6) levels. A significant increase in IL-6 production was seen in mice immunized with lead-altered MBP but not with lead-altered GFAP. No changes were observed in the IL-2 levels of mice immunized with either lead-altered protein.(ABSTRACT TRUNCATED AT 250 WORDS)
INTRAUTERINE MALNUTRITION
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
From Infancy Through Childhood
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Counting Calories—Caveat Emptor
Authors: David B. Allison
Journal: JAMA (1993)

<h3>Objective.</h3> —To determine the accuracy of caloric labeling of "diet" and "health" foods and whether the accuracy differs for certain categories of food suppliers. <h3>Design.</h3> —Survey; "diet" and "health" foods were analyzed via bomb calorimetry and categorized as regionally distributed, nationally advertised, or locally prepared. <h3>Setting.</h3> —Foods were sampled from retail merchants throughout the borough of Manhattan, New York, NY. <h3>Sample.</h3> —A convenience sample of 40 food items including regionally distributed (n=12), nationally advertised (n=20), and locally prepared items (n=8). <h3>Main Outcome Measures.</h3> —Number of kilocalories per item and number of kilocalories per gram. <h3>Results.</h3> —All locally prepared foods had more actual than labeled kilocalories. The mean percentage of actual kilocalories greater than the labeled kilocalories (mean percentage over label) per item was 85.42% (SD=77.88%;<i>P</i>=.01). Regionally distributed foods had significantly more kilocalories than were reported (<i>P</i>=.001 for kilocalories per item,<i>P</i>=.02 for kilocalories per gram) and mean percentage over label per item was 25.22% (SD=15.58%) and per gram was 14.97% (SD=17.95%). Nationally advertised foods did not have significantly more actual than reported kilocalories (<i>P</i>=.37 for per item,<i>P</i>=.78 for per gram). Mean percentage over label per gram was —0.01% (SD=9.13%) and per item was 2.18% (SD=13.93%). <h3>Conclusion.</h3> —These findings suggest that food labels may be inadequate sources for caloric monitoring. Health care professionals should consider the accuracy of caloric labeling when advising patients to use food labels to help monitor their caloric intake. (<i>JAMA</i>. 1993;270:1454-1456)
The Central Regulation of Bone Mass, the First Link between Bone Remodeling and Energy Metabolism
Authors: Gerard Karsenty, Franck Oury
Journal: Endocrine Reviews (2010)

Abstract Evolutionary consideration and clinical observations led us to hypothesize 10 yr ago that there may be a coordinated regulation, endocrine in nature, of bone remodeling and energy metabolism. The existence of this coordinated regulation is motivated by the energetic needs of the skeleton; therefore, this regulation relies on hormones that appear during evolution with the skeleton, not with energy metabolism. Leptin is such a hormone, and it is a critical regulator of bone mass as well as of appetite and energy expenditure. This review goes over the anatomical route and molecular pathways used by leptin to inhibit both bone mass accrual and appetite through its signaling in the brain.
IS THE ANTIPYRIN CRAZE HARMLESS?
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Left Atrial Ectopic Rhythm in Mirror-Image Dextrocardia and Normally Placed Malformed Hearts
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Health Professions Educational Assistance Act of 1976
Authors: L. D. Fenninger
Journal: JAMA (1976)

President Ford signed into law the Health Professions Educational Assistance Act of 1976 (PL 94-484) on Oct 12, 1976. A discussion of some of the issues that were considered during the prolonged development of this legislation appears elsewhere in this number ofThe Journal. Effective and suitable relationships between the federal government, including the Congress and the Executive, and the schools of the health professions have been at the heart of much of the debate. In fact, inherent in the differences, discussions, and deliberations has been the fundamental question of whether higher education, the individual students who are pursuing it, and the institutions that provide the setting for higher education should be subjected to federal regulation as the requirement for eligibility for resources collected from the public and redistributed by the federal government. Although the legislation itself applies directly only to the schools of the health professions, the regulatory provisions
<i>QuickStats</i>: Age-Adjusted Percentages* of Adults Aged ≥18 Years Who Are Current Regular Drinkers of Alcohol,<sup>†</sup> by Sex, Race, and Hispanic Origin<sup>§</sup> — National Health Interview Survey, 2016<sup>¶</sup>
Journal: MMWR Morbidity and Mortality Weekly Report (2018)

In 2016, men aged ≥18 years were more likely than women to be current regular drinkers of alcohol (62.1% versus 47.2%). Non-Hispanic white men (65.5%) were more likely to be current regular drinkers than Hispanic men (57.8%) and non-Hispanic black men (52.9%). Non-Hispanic white women (55.6%) were more likely to be current regular drinkers than non-Hispanic black women (35.9%) and Hispanic women (31.5%).
Radiation—Excision
Authors: Dan J. Kindel, H. Jerry Lavender, Alfred L. Weiner
Journal: JAMA (1964)

<h3>To the Editor:—</h3> The attention of the Cincinnati Dermatological Society, consisting of 45 diplomates of the American Board of Dermatology, has been directed to the news item, "Radiotherapy Belongs to History." The Society believes that the author's statements regarding poor results and recurrences following x-ray therapy for skin cancers are open to question. He also implies that dermatologists and radiotherapists are inadequate in the management of radiation therapy for carcinomas. He consigns radiotherapy to the scrap heap when radiotherapy itself is not to blame but rather the improper use of this modality in the treatment of skin cancers. The results that he quotes are certainly not substantiated by any statistical results that can be found in this country and certainly his estimate of 39% recurrent malignant lesions estimated by some workers is in no way comparable to the results of radiation therapy in this country, where the cure rate is
The preliminary report of the findings of the aspirin component of the ongoing Physicians' Health Study. The FDA perspective on aspirin for the primary prevention of myocardial infarction
Authors: F. E. Young
Journal: JAMA (1988)

RECENTLY, physicians, their patients, and the population at large simultaneously became aware that a large study of the effects of aspirin use in healthy men had been stopped because of a dramatic favorable effect of aspirin use on the rate of acute myocardial infarction. A special report<sup>1</sup>that gave the results of the aspirin component of the ongoing Physicians' Health Study appeared in the Jan 28, 1988, issue of the<i>New England Journal of Medicine</i>, accompanied by an editorial<sup>2</sup>and a barrage of publicity in the lay press. The print and electronic media almost immediately carried advertising directed toward the lay public about the use of aspirin to prevent myocardial infarction. (The Food and Drug Administration [FDA] regulates the<i>labeling</i>of over-the-counter drugs and the Federal Trade Commission regulates the<i>advertising</i>of over-the-counter drugs.) Given the preliminary nature of the published report, the lack of extensive critical scientific
PRACTICAL NOTES.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nitrazepam nightmares.
Authors: R H Girwood
Journal: BMJ (1973)

ried out with the patients in group B, ex- cept they were told that the new drug was acting and that their blood pressure had decreased.The true blood pressures, all of which showed decreases, were recorded each day as percentages of the patient's basic systolic and diastolic levels established before treat- ment began.The mean of these percentages were then taken for each patient in each group and the average of these means taken as representative of each group for com- parison with the other group.These showed that in group A at the end of the treatment the systolic blood pressure was 90-8% of the pretreatment level and the diastolic pressure 93 0% of the pretreatment level.The corres- ponding figures for group B were 95-8% and 97 2%.The differences in the systolic and diastolic values between the two groups were not statistically significant (P > 0-1 and > 0 2).Our results in this short trial show that posi- tive or negative information given to the patient does not influence the changes of blood pressure produced by effective hypo- tensive agents.Therefore the doctor's attitude toward the patient probably does not affect the evaluation of antihypertensive drugs.-Weare, etc.,
Surgery of The Brain And Spinal Cord.
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A translational mouse model for NASH and advanced fibrosis in association with atherosclerosis
Authors: Anita M. van den Hoek, Nicole Worms, Anita van Nieuwkoop, Christa de Ruiter, Aswin Menke, Sridhar Radhakrishnan, Martine C. Morrison, Kanita Salic, Robert Kleemann
Journal: Journal of Hepatology (2020)
The Thyroid Gland
Authors: Milton W. Hamolsky, A. Stone Freedberg
Journal: New England Journal of Medicine (1960)

(Concluded)*Laboratory Diagnostic Tests of Thyroid Function and DiseaseThe multiplicity of laboratory tests directed at an elucidation of thyroid function offers both a boon and a challenge to the physician. The time-honored determinations of basal metabolic rate and blood cholesterol, the widely used serum protein-bound iodine levels and thyroid uptake of radioactive iodine have been joined by the serum level of butanol-extractable iodine, the I131 conversion ratio, the thyroid I131 clearance, the salivary I131 excretion, the thyroid-suppression tests, the T.S.H. stimulation test, the in vitro erythrocyte uptake of I131-labeled triiodothyronine, to mention a few of the more prominent . . .
Cataract Extraction Rates and insurance Status
Authors: Eric A. Peterson
Journal: JAMA (1997)

<h3>To the Editor.</h3> —Dr Goldzweig and colleagues<sup>1</sup>have added cataract extraction to the growing list of procedures and conditions for which practice patterns differ substantially between managed care and FFS settings. The differences they found in cataract extraction rates were strikingly large, on the order of 2 to 1. Nonetheless, it is not clear what to make of these differences. Because Goldzweig and colleagues did not assess the extent to which these surgeries were indicated for the patients who underwent them, we cannot tell how much their findings reflect either overtreatment of FFS patients or undertreatment of managed care patients. Depending on which of these 2 circumstances predominates, both the nature of the problem (if any) and potential solutions would vary enormously. Thus, from both clinical and policy perspectives, the critical question is not whether managed care and FFS lead to different practice patterns, but rather what implications any such differences have
Medical Education, Registration and Hospital Service
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Inside Back Cover Image, Volume 41, Issue 3
Authors: Sezen Vatansever, Avner Schlessinger, Daniel Wacker, H. Ümit Kaniskan, Jian Jin, Ming‐Ming Zhou, Bin Zhang
Journal: Medicinal Research Reviews (2021)

The cover image is based on the Review Article Artificial intelligence and machine learning-aided drug discovery in central nervous system diseases: State-of-the-arts and future directions by Sezen Vatansever et al., https://doi.org/10.1002/med.21764.
The Prevention of Disease. Translated from the German with an Introduction
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Surgery of the Autonomic Nervous System
Authors: Reginald H. Smithwick
Journal: New England Journal of Medicine (1947)

THE following phases of the surgery of the autonomic nervous system will be considered: operations on the sympathetic division; the pathologic and physiologic aspects of the hypertensive state; and operations on the parasympathetic division.Operations on the Sympathetic DivisionThe treatment of hypertension and hypertensive cardiovascular disease by operations on the sympathetic division of the autonomic nervous system continues to be the topic of greatest current interest in this field of surgery. The rationale was well stated by Rowntree and Adson1 in 1925 in what appears to be one of the first articles on this subject. The authors discussed their . . .