tbuckley/cabot-search huggingface dataset:
ADDRESS.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Use of cromolyn in combined gastrointestinal allergy
Authors: S. Kocoshis
Journal: JAMA (1979)

A double-blind clinical trial was undertaken to evaluate the efficacy of orally given cromolyn sodium vs that of placebo in the management of food allergy. Fourteen children, aged 2 to 15 years, with milk allergy and concomitant allergies to one or more foods were given cromolyn or placebo. Eleven had positive intradermal skin reactions or coproantibodies to offending antigens. Treatment was begun while the children were receiving elimination diets; they were challenged with specific antigen only after 48 hours of drug administration. Crossover took place if the initial agent was ineffective. Cromolyn afforded protection in 11 of 13 trials, whereas placebo was effective in only three of nine trials. By χ<sup>2</sup>analysis, the drug's effect was statistically significant. (<i>JAMA</i>242:1169-1173, 1979)
'Doctors must not kill'
Authors: W. Gaylin
Journal: JAMA (1988)

IN THE middle of the night, a sleepy gynecology resident is called to attend a young woman, dying of cancer, whom he has never seen before. Horrified by her severe distress, and proceeding alone without consultation with anyone, he gives her a lethal injection of morphine, clearly intending the death that promptly ensues. The resident submits a first-person account of his killing to the<i>Journal of the American Medical Association</i>. Without any editorial comment,<i>JAMA</i>publishes the account, withholding the author's name at his request. What in the world is going on? Before the sophisticated obscure our vision with clouds of arguments and subtle qualifications, we must fix our gaze on the brute facts. First, on his own admission, the resident appears to have committed a felony: premeditated murder. Direct intentional homicide is a felony in all American jurisdictions, for which the plea of merciful motive is no excuse. That
Checkpoint Inhibitor–TKI Combos Effective in RCC
Journal: Cancer Discovery (2019)

Abstract Pembrolizumab or avelumab plus axitinib may be effective first-line treatments for clear-cell advanced renal cell carcinoma. In a pair of phase III trials, the checkpoint inhibitor–tyrosine kinase inhibitor combinations extended progression-free survival compared with sunitinib and were associated with relatively manageable side effects.
Augmentation of Pulmonary Reactions to Quartz Inhalation by Trace Amounts of Iron-Containing Particles
Authors: Vincent Castranova, Val Vallyathan, Dawn M. Ramsey, Jeffrey L. McLaurin, Donna Pack, Steven Leonard, Mark W. Barger, Jane Y. C. Ma, Nar S. Dalal, Alex Teass
Journal: Environmental Health Perspectives (1997)
Detection of cancer cells in mesenteric and peripheral veins by measuring telomerase activity in colorectal cancer patients
Authors: H. Nozawa, T. Watanabe, T. Ohnishi, T. Tada, G. Tsurita, S. Sasaki, J. Kitayama, H. Nagawa
Journal: Journal of Clinical Oncology (2004)

3628 Background: Liver metastasis is an important factor that determines prognosis in colorectal cancer (CRC). Several attempts such as RT-PCR analyses of certain genes have been applied for detecting cancer cells since their shedding into the drainage veins is considered the initial step of metastasis. In this study, we measured telomerase activity to assess the existence of malignant cells in the drainage veins and further examined if its detection is correlated with synchronous and metachronous liver metastasis. Methods: Blood samples were collected from mesenteric (tumor-drainage) vein and peripheral vessels in 41 CRC patients before mobilizing the tumor-bearing segment. Peripheral blood samples from 6 healthy people were served as negative controls. ELIDA-linked TRAP assay in combination with immunomagnetic sorting was employed for measuring telomerase activity. The activity was calculated as relative telomerase activity (RTA; %) against a known amount of a control telomeric repeat template. All the patients have been followed up until 12 to 24 months after the initial operation. Results: RTA of mesenteric blood sample was higher in patients with synchronous and/or metachronous liver metastasis (47.3; n=9) than in metastasis-free patients (21.0; n=32, p=0.12). The RTA of peripheral blood sample also tended to be higher in the patients with liver metastasis (22.4) than in those without metastasis (11.4, p=0.20). On the other hand, the average and maximum RTAs of blood from healthy volunteers were 8.4 and 32.7, respectively. When we defined 32.7 as the threshold of positive telomerase activity, 40% of cases showing positive activity in mesenteric blood sample developed liver metastasis. In contrast, 16% of the others whose mesenteric blood samples failed to exhibit telomerase activity had liver metastasis. Conclusions: Our assay is a feasible method for detecting cancer cells in tumor-drainage veins. Elevated telomerase activity of mesenteric blood samples possibly reflected the development of liver metastasis of CRC. No significant financial relationships to disclose.
Patrick Huck
Journal: BMJ (2006)

British family planning doctor whose assisted suicide in a Swiss clinic refuelled UK euthanasia debate Anne Turner's final trip to continental Europe was one she resented having to make.She loved travelling to Europe, often for the opera.But having decided to kill herself, she felt frustrated at the need to leave the comfort of her cosy bungalow in Bath.However, with typical self assurance, Dr Turner made precise plans.She would die in Switzerland on 24 January 2006, the day before her 67th birthday.Events early in the childhood of the woman dubbed "Boadicea" by a friend can probably be credited for the independence and strength of character that she exhibited throughout her life.Just 18 months after her birth in Harrogate in 1939, she was evacuated, with her sister, from war torn Europe to Vancouver in Canada.She only just made it.A German U boat sank the vessel behind the one in which she was travelling and such evacuations promptly ceased.But having safely reached North America, she enjoyed living with cousins and a grandmother.In 1945 however, she returned to Westerham, Kent, in England and to parents she didn't know-and to the austere, postwar landscape.She would later joke that it felt as if she had been evacuated to the United Kingdom rather than returned home.After her carefree existence in Canada, the grey skies, food rations, and lack of central heating did not endear her to her native land.Her father, a civil servant, and her mother, a local councillor, were strict and somewhat distant parents.So being packed off to boarding school in 1952 seemed more like a release than a frightening trip into the unknown.Shortly after leaving school a lifethreatening adder bite provided a first glimpse of her mortality.Her response was not fear but curiosity.And from this near-death experience she decided that dying was as easy as going to sleep.In 1958 she went to St Thomas' to study medicine.On the first day she met her future husband, Jack Turner.After qualifying, they worked in the south of England before settling in Bath, where they found jobs in general practice and began a family.Anne Turner soon developed an interest in family planning, and was to play a key role
IN THIS ISSUE
Journal: JNCI Journal of the National Cancer Institute (2011)

Breast Randomized Trials in Patients with Stage I SeminomaBetween 1989 and 2001, 2466 patients with stage I seminoma were evaluated in three randomized non-inferiority adjuvant treatment trials (the TE10, TE18, and TE19 trials).Mead et al. (p.241) analyzed mature results of these studies after median follow-up times of 6.4-12 years.The TE10 trial results confirmed the noninferiority of para aortic versus dog leg radiotherapy, given to a dose of 30GY.In the TE18 trial, they identified the noninferiority of 20-Gy of radiation therapy (compared with 30-Gy).In the TE19 trial, they confirmed the noninferiority of carboplatin chemotherapy (compared with radiation therapy).Relapse 3 years after therapy occurred in only four of all 2466 patients.The authors conclude that mature data from these three trials provide support for the use of either radiation therapy or carboplatin chemotherapy as adjuvant treatment for stage I seminoma.
The Dietary Habits of American College Girls
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Video Comment on Mohammad Yaghoobi et al.
Journal: Endoscopy (2015)

See also: Incidence and predictors of post-ERCP pancreatitis in patients with suspected sphincter of Oddi dysfunction undergoing biliary or dual sphincterotomy: results from the EPISOD prospective multicenter randomized sham-controlled studyEndoscopy 2015; 47(10): 884-890DOI: 10.1055/s-0034-1392418
AMERICAN JOURNAL OF DISEASES OF CHILDREN
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Megavitamin Therapy
Authors: Andrew A. Recsei
Journal: JAMA (1976)

<h3>To the Editor.—</h3> Dr Jukes writes (234:806, 1975), "The argument about the 'slice of liver' is not persuasive; consumption of polar bear liver has caused vitamin A poisoning." This is the type of argument that should never be used. The "slice of liver" referred to by Dr Pauling is obviously the commonly consumed beef liver. A slice of beef liver (approximately 100 gm) contains 40,000 units of vitamin A. The same amount of polar bear liver contains 2 million units! I wonder how many of us are exposed to this danger.
Antenatal depression
Authors: Anne Hardiman, Jennifer Davies
Journal: BMJ (2009)

This forgotten side of pregnancy can be lonely and miserable Imagine that you’re 33 weeks into your first pregnancy. It’s going well, the baby’s growing and is healthy, and you’re in a loving relationship with the father. You’re excited about starting a family and can’t wait to meet your new little one. Now imagine that you’re 33 weeks into your first pregnancy, and everyone around you is excited and happy for you, after all, pregnancy is a time when you should be blooming. But you’re feeling alone, isolated, terrified, and anxious. You feel guilty for feeling like this so you hide it, thinking that no one will understand. You have antenatal depression, and you’re not alone. Often overshadowed by postnatal depression, antenatal depression is in fact more common. Postnatal depression can be devastating, and it can wreck the lives of new mums, but little attention is given to expectant mums who may be feeling depressed before the baby arrives. The sixth triennial report of the Confidential Enquiry into Maternal and Child Health in 2002 identified psychiatric illness as the leading cause of maternal death in the United Kingdom, second only to cardiac disease.1 The report also said that out of those women who had deaths related to psychiatry, 62% received substandard care.1 A UK study in 2001 found that prepartum depression is more common than postpartum depression, and 10% of all pregnant women experience some degree of antenatal depression.2 So one in 10 women in a clinic or the maternity ward are experiencing antenatal depression, mostly alone. Would you be able to spot this? Mood swings and the “pregnancy blues” are relatively common in pregnancy; clinical depression is more than this. The main symptoms to look for are3:
Errors in Byline and Affiliations
Authors: David Li, Arash Mostaghimi
Journal: JAMA Dermatology (2019)

out of in vivo bioequivalence testing in 5 cases, while recommending comparative physicochemical characterization in the final case. 5 Given these requirements, it is likely that existing FDA requirements may dissuade manufacturers from entering these restricted markets.Although we are in complete support of efforts to streamline drug approval, variations between topical medications may render in vitro evaluation unsuitable for some medications.For example, differences in vehicle can potentially alter the performance of a generic formulation in a manner that may not be captured by in vitro studies alone. 3,6Additionally, the intrinsic properties of select topical drugs may interfere with the reliability of in vitro testing.One recent study illustrated the difficulty of standardizing the in vitro release test for betamethasone valerate owing to its high solubility in hydrophobic barriers. 3espite these differences, the FDA's rationale for mandating in vivo studies for some drugs while allowing the in vitro option in others is not fully elucidated.Development and validation of criteria to identify topical drugs that can be granted an in vitro testing option may improve throughput of new medications without compromising trust in the equivalent performance of generic medications entering the market.While these criteria are being developed, short-term improvements in market competition may be realized by subsidizing a portion of costs associated with clinical trials for generic drug manufacturers entering restricted markets.Although we agree that the current recommendations for bioequivalence studies may discourage drug manufacturers, a rapid transition toward in vitro testing may compromise the integrity of topical dermatology generic drugs reaching the market.Until researchers and regulators can decide on a transparent and standardized framework for the design of bioequivalence studies, barriers to entry will continue to limit the impact of competition on keeping topical drug prices in check.
MADRID
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Evaluation of a Fruit and Vegetable Distribution Program—Mississippi, 2004-05 School Year
Journal: JAMA (2006)

Although diets high in fruit and vegetables are associated with decreased risk for many chronic diseases, consumption of fruit and vegetables among children is below recommended levels. During the 2004-05 school year, the Mississippi Department of Education Child Nutrition Program initiated the Mississippi Fresh Fruit and Vegetable Pilot Program. The program was designed to 1) increase student access to fresh fruit and vegetables, 2) increase the degree of student preference for fruit and vegetables, and 3) increase fruit and vegetable consumption. The 25 schools selected to participate in the program distributed fresh fruit and vegetables free of charge during the school day and provided nutrition education activities to promote and support consumption of fruit and vegetables. An evaluation of the program was conducted using a pretest in the fall (before the program was implemented by the schools) and a posttest in the spring (at the end of the school year). This report summarizes the findings of that evaluation, which indicated that the program might have 1) increased the variety of fruit and vegetables ever tried by students from all three grades sampled (5th, 8th, and 10th); 2) increased the degree of preference for fruit among 8th-grade and 10th-grade students; 3) promoted positive attitudes toward eating fruit among 8th-grade students; 4) increased consumption of fruit, but not vegetables, among 8th-grade and 10th-grade students; and 5) decreased preference for fruit and vegetables, the belief that they could eat more vegetables, and willingness to try new fruit and vegetables among 5th-grade students. The results of this evaluation suggest that the distribution of fresh fruit at school free of charge to secondary school students might be an effective component of a comprehensive approach for improving student dietary behaviors; however, distribution of fresh vegetables might be more effective with changes in program implementation.
History
Authors: Raymond Wolters
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal