tbuckley/cabot-search huggingface dataset:
CPR-Not-Indicated and Futility
Authors: Robert A. Pearlman
Journal: Annals of Internal Medicine (1996)

Letters1 January 1996CPR-Not-Indicated and FutilityRobert A. Pearlman, MD, MPH and Nancy S. Jecker, PhDRobert A. Pearlman, MD, MPHSeattle Veterans Affairs Medical Center; Seattle, WA 98108University of Washington; Seattle, WA 98195Search for more papers by this author and Nancy S. Jecker, PhDSeattle Veterans Affairs Medical Center; Seattle, WA 98108University of Washington; Seattle, WA 98195Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-124-1_Part_1-199601010-00028 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Waisel and Truog's article [1] misrepresents the Seattle Veterans Affairs (VA) Medical Center policy on do-not-resuscitate orders in two important respects. First, the VA policy acknowledges that values enter into determinations of quantitative and qualitative futility. Rather than allowing the physician's values to determine judgments of medical futility, the policy promotes shared decision making. It requires that physicians discuss their judgments of medical futility with the patient or surrogate and obtain agreement before writing a do-not-resuscitate order. In the absence of agreement, the policy outlines a conflict resolution process. As an academic teaching facility, the VA Medical ...REFERENCE1. Waisel DB, Truog RD. The cardiopulmonary resuscitation-not-indicated order: futility revisited. Ann Intern Med. 1995; 122:304-8. Google Scholar Author, Article, and Disclosure InformationAffiliations: Seattle Veterans Affairs Medical Center; Seattle, WA 98108University of Washington; Seattle, WA 98195 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByEthics of Codes and Codes of Ethics 1 January 1996Volume 124, Issue 1_Part_1Page: 76-77KeywordsDecision makingDo not resuscitate orders Issue Published: 1 January 1996 CopyrightCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
This Month's Highlights
Journal: Journal of the American Society of Nephrology (2008)

### Endothelium Gives Rise to Fibroblasts Fibroblasts play a major role in fibrogenesis in the kidney and other organs. Activated fibroblasts in the renal parenchyma arise from resident quiescent fibroblasts, from epithelial cells (through epithelial-to-mesenchymal transition), and from the bone
The alcoholism of Eugene O'Neill
Authors: D. W. Goodwin
Journal: JAMA (1971)

Two psychiatrists have won the Nobel Prize for medicine—Julius Wagner-Jauregg for the malarial treatment of neurosyphilis, and Antonio Moniz for promoting lobotomy. More deserving than either, perhaps, was Gilbert V. Hamilton. As a young New York psychoanalyst in the mid 1920s, Hamilton converted America's greatest playwright from a ferocious alcoholic into a dedicated teetotaler, and did it all in six weeks. In the process he may also have transformed his patient, Eugene O'Neill, from a spectacularly productive playwright into a recluse who went 12 years without having a play on Broadway, but this cannot be proven. His cure of O'Neill's drinking problem, on the other hand, surely must represent one of the outstanding medical triumphs of the century. It all happened in a most peculiar manner. Hamilton had received a grant to survey the sexual practices of married people. His subjects included Mr. and Mrs. Eugene O'Neill. Hamilton later received
Efficacy and adverse events of oral isotretinoin for acne: a systematic review
Authors: I.A. Vallerand, R.T. Lewinson, M.S. Farris, C.D. Sibley, M.L. Ramien, A.G.M. Bulloch, S.B. Patten
Journal: British Journal of Dermatology (2018)

Acne vulgaris, usually just referred to as acne, is the most common skin disease. It causes red spots, pus‐filled spots and blackheads and can vary in severity from mild to severe. Because it can be very visible, it can cause anxiety, reduced self‐esteem and stigma. In cases of more severe acne that hasn't improved with other treatments, a powerful drug taken orally (by mouth) called isotretinoin can be prescribed by doctors. This study, from Canada, reviewed evidence from randomized controlled trials (RCTs) to assess the efficacy and safety of isotretinoin. RCTs are studies in which a number of patients are randomly allocated to two or more test groups, one of which will be a ‘control’ group (who typically receive either no treatment, standard care or a placebo), while the other groups will receive the specific treatments being tested. The different groups of patients are then monitored in the exact same way, allowing for direct comparison between different treatments. Eleven trials were identified, involving a total of 760 patients ‐ mostly males. Across all trials, isotretinoin reduced acne lesion counts (number of spots), and always by a greater amount than controls, which were either placebo, oral antibiotics, or another control type. The frequency of adverse events, meaning unwanted side effects, was twice as high with isotretinoin (751 events) compared to control (388 events). More than half of all adverse events related to skin dryness. Adverse events caused 12 of the 760 participants to withdrawal from trials, due to the development of Stevens‐Johnson Syndrome, cheilitis, xerosis, acne flare, photophobia, elevated liver enzymes, decreased appetite, headaches and depressed mood. This review suggests that isotretinoin is effective in reducing acne lesion counts, but adverse events are common.
Epidemiology of subacute sclerosing panencephalitis (SSPE). A report of the SSPE registry
Authors: J. T. Jabbour
Journal: JAMA (1972)

In this report of the Subacute Sclerosing Panencephalitis (SSPE) Registry during 1960 through 1970, the findings indicate a 50% relationship of SSPE to early (under 2 years of age) measles infection. The frequency of SSPE is one per million, and a majority of the patients reside in the southeastern part of the United States.
HGCSG1401: A retrospective cohort study evaluating the safety and efficacy of regorafenib in patients with metastatic colorectal cancer: Analysis of risk factors for liver dysfunction
Authors: T. Honda, S. Yuki, T. Muranaka, H. Nakatsumi, Y. Tsuji, T. Miyagishima, S. Yoshida, K. Hatanaka, T. Sasaki, A. Ishiguro, O. Muto, H. Ohnuma, S. Kato, A. Sato, M. Abe, K. Kato, K. Onodera, K. Eto, M. Tateyama, T. Amano, Y. Sakata, Y. Komatsu
Journal: Annals of Oncology (2018)

Introduction: Regorafenib (REG) prolongs overall survival (OS) and progression-free survival (PFS) for patients (pts) with metastatic colorectal cancer (mCRC) in RCTs. However, there is a problem with REG-induced severe liver dysfunction (≥Grade 3) which occurs in 5-11% of treated Japanese pts. Therefore, we analyzed the incidence, therapeutic efficacy, and potential risk factors for REG-induced severe liver dysfunction in a community-based retrospective study (HGCSG1401) of pts treated with REG. Methods: 173 pts treated with REG were retrospectively registered from 22 centers in Japan. Survival analyses were performed with Kaplan-Meier method. Log-rank test and Cox-proportional hazard model were used to compare Grade 0-2 and 3-5. To identify risk factors for REG-induced severe liver dysfunction, a multivariate analysis was performed using the logistic regression analysis with backward elimination for variables with p < 0.10 in univariate analysis. Results: In 173 eligible pts, 24 (13.9%) experienced REG-induced severe liver dysfunction. The median PFS of Grade 0-2 and 3-5 were 2.2 and 1.6 months, respectively. The median OS of Grade 0-2 and 3-5 were 6.9 and 3.4 months, respectively. In the analysis of PFS and OS, there were significant difference between Grade 0-2 and 3-5 (PFS: HR 1.578, p = 0.045, OS: HR 1.799, p = 0.010). Univariate analyses showed that high AST, LDH, ALP, and GGT level at baseline were associated with REG-induced severe liver dysfunction. In multivariate analyses, high baseline AST level (≥ 50 U/L) was significantly associated with increased risk of REG-induced severe liver dysfunction (odds ratio=3.458, p = 0.032). Conclusion: Compared with previous reports, this analysis showed the slightly higher incidence of REG-induced severe liver dysfunction (13.9%). In multivariate analysis, it was inferred that high AST level (≥ 50 U/L) at baseline might be an independent risk factor. REG-induced severe liver dysfunction population significantly showed shorter OS than mild liver dysfunction. It is presumed that this patient population could not receive TAS-102 as post regorafenib therapy. Since this is an exploratory analysis, we consider it necessary to verify in large data set.
Elderly Diabetics
Authors: J T HUGHES
Journal: BMJ (1964)

MBIJORNLcontrol of industrial health hazards should not depend on the ability and willingness of the employer to pay.6 7 Another factor worth noting is the varying degree of co-operation between industrial health services and the National Health Service.Liaison may be difficult between general practitioner, hospital consultant, and industrial medical officer, especially in those emergencies when a patient is transferred direct from factory to hospital owing to accident or illness.The acceptance of the industrial medical officer by his colleagues in general practice appears to vary in different parts of the country, and there is general agreement that services in the nationalized and the large privately owned industries have been accepted more than those in the smaller units.These prejudices are, however, gradually disappearing and mutual co-operation and understanding is now the rule.The subject of training in industrial health, both at under- graduate and at postgraduate levels, is rightly stressed in this report, for the expansion of industrial health services requires more medical men and women trained in the specialty.Diplomas (D.I.H.) are offered at London and Dundee, and
Accident Liability
Authors: Manuel Rodstein
Journal: JAMA (1974)

ACCIDENT liability is a broad term that includes all personal factors determining the occurrence of accidents. Included within this definition would be the effects of acute and chronic illness, the aging process, drugs, and accident proneness. Accidents are often triggered by specific conditions such as darkness, heat, cold, haste, inexperience, noise, startle, and glare. Often, accidents are potentiated by the effects of alcohol, drugs, acute and chronic illness, and the degenerative changes of the aging process. Chronic illness, medications, depression, and the effects of the organic mental syndrome in later life lead to apathy and a sense of detachment from the environment, with lessened alertness, decreased selfcare, and an increased propensity to accidents. Acute illness may also lead to accidents. In the aged, especially, a premonitory accident may commonly be the first manifestation of an acute disease, or an accident may occur shortly after clinical onset of a disease. Among
Fister Warns Against Excess Enthusiasm
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CORONARY THROMBOSIS
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Anterior Colporrhaphy versus Transvaginal Mesh for Pelvic-Organ Prolapse
Journal: New England Journal of Medicine (2013)

corrections toms are thought to be uncommon in winter, it seems like ly that the rhinoconjunctivitis in these children might have been attributed to a common cold.Just over a decade ago, 96 hybrid trees with high winter resistance (Alnus x spaethii: A. japonica x A. subcordata) were planted along a main boulevard in Buchs, where children walk or ride the bus on their way to school in Grabs.This leads to almost daily pollen exposure during the flowering season, which for alders in this region of Switzerland is in December (Fig. 1).Near Christmas of 2011, large amounts of alder pollen were noted in the trap.It seems likely that this newly introduced plant species, along with changing temperatures and street lighting, may have influenced the release of pollens in winter, 4 which led to the allergic sensitization to alder and the gift to many children of a runny nose at Christmas. 5
Maintenance dialysis after 20 years
Authors: G. Dunea
Journal: JAMA (1980)

"In the lay mind, the kidneys seem to join the heart and brain in the inner circle of really vital organs, while the lethal potentialities of diseases of the lungs, liver, stomach, and blood-vessels are less seriously regarded." Thus wrote Sir Douglas Black 20 years ago almost to the very day, quoting Sir Walter Scott's pessimistic view that "when a man makes blood instead of water, he is tempted to think of the possibility of his soon making earth."<sup>1</sup>Yet even closer to the graveyard, within living memory, was the luckless person who made no water whatsoever, or whose sclerotic glomeruli reluctantly squeezed out so insubstantial a secretion that life miserably ebbed away until stupor, convulsions, and coma mercifully secured a release from living death. All this began to change when Quinton et al<sup>2</sup>contrived to connect the arterial cannula directly to the venous, "thereby creating a small
Candidate interactions
Authors: F. Kauffmann, R. Nadif
Journal: European Respiratory Journal (2007)

1] present the results of their study on functional polymorphisms of the b 2 -adrenoceptor (ADRB2) gene in relation to passive smoking on lung function and exhaled nitric oxide fraction (FeNO) in children 11 yrs of age.They gathered 147 children with contrasted exposure to passive smoking, taking into account exposures recorded at 1 month of age, 6 and 11 yrs.They concluded that smoking had a significant effect on associations between ADRB2 polymorphisms and asthma related phenotypes enhancing the deleterious effect of Arg16 on lung function.No less than three meta-analyses on the associations of ADRB2 polymorphisms with asthma have been published recently [2-4], with the latter including a new study with data on a large sample studied from childhood to middle age.Overall, there is still no clear pattern and the attributable fraction of ADRB2 polymorphisms to asthma, when considered globally, is likely to be low.However, there is a rather consistent pattern that the Gly16 allele (or Gly16Gln27 haplotype), which is functionally associated with enhanced receptor function, has a protective role towards subphenotypes of asthma in relation to age, specific expression of the disease, such as nocturnal symptoms, and interaction with environmental factors.
Peroxisome proliferator–activated receptor (PPAR)α expression in T cells mediates gender differences in development of T cell–mediated autoimmunity
Authors: Shannon E. Dunn, Shalina S. Ousman, Raymond A. Sobel, Luis Zuniga, Sergio E. Baranzini, Sawsan Youssef, Andrea Crowell, John Loh, Jorge Oksenberg, Lawrence Steinman
Journal: The Journal of Experimental Medicine (2007)
CARBOLIC ACID AND ITS DANGER.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Under Pressure
Authors: Ersilia M. DeFilippis, Anand Vaidya, Subha Ramani, Christopher French, James M. Kirshenbaum
Journal: New England Journal of Medicine (2017)

A 61-year-old man presents to the emergency department with shortness of breath and cough. Earlier that morning, he had sudden onset of dyspnea and tightness in his chest. The chest tightness had resolved, but he continued to feel short of breath. He reported no fevers but did have a productive cough.
Short-term tuberculosis therapy regimens
Authors: W. W. Stead
Journal: JAMA (1979)

<h3>To the Editor.—</h3> The article "Will Short-term TB Therapy Regimens Work?" in MEDICAL NEWS (240:2526, 1978) by John Elliott contained two substantive errors that should be corrected. First, Mr Elliott accurately described the dosage of the largely twice-weekly regimen of rifampin and isoniazid that we have employed in our nine-month course of therapy; however, he then stated "the PHS [Public Health Service] program...involves similar doses, but the regimen lasts only six months." Actually, the PHS program calls for rifampin and isoniazid to be given in standard doses daily for six months, then followed in one group by a combination of isoniazid and ethanbutol hydrochloride and in a second group by a period of placebo. But both groups get rifampin and isoniazid daily for six months. Second, in an effort to account for the much lower drop-out rate and greater success of the Arkansas program over that of the PHS,
Vidarabine monophosphate and human leukocyte interferon in chronic hepatitis B infection
Authors: C. I. Smith
Journal: JAMA (1982)

Ten young adult male patients with chronic hepatitis B virus infection and positive hepatitis B e antigen and DNA polymerase (DNAP) levels were treated with alternating courses of seven to 28 days of 5 to 7.5 mg/kg of vidarabine monophosphate (adenine arabinoside monophosphate) and 28 days of human leukocyte interferon (IFN-α); three different regimens were given on an outpatient basis. All patients responded with a fall in their DNAP level, and the DNAP remained undetectable six months after treatment was stopped in one patient. The major side effect, which most often occurred in those patients receiving 7.5 mg/kg of vidarabine monophosphate, was severe muscular pains. This study demonstrated the feasibility of administering vidarabine monophosphate and interferon to outpatients. Based on data from this and other studies, it is now possible to use a relatively nontoxic regimen that includes 28 days of 5 mg/kg of vidarabine monophosphate in a larger controlled study to answer the question of efficacy. (<i>JAMA</i>1982;247:2261-2265)
Crystalglobulinemia
Authors: JAY GROSSMAN
Journal: Annals of Internal Medicine (1972)

A cryoprotein consisting of spontaneously formed crystals of gamma globulin (IgG3K) has been found in the serum of a 54-year-old woman who has had repeated episodes of widespread purpura and necrotic cutaneous ulcerations. No renal disease or involvement of other organ systems have been observed. Analyses of the patient's serum showed microscopic crystals of gamma globulin comprising at times almost 50% of her serum volume when cooled to 4 °C. Treatment with corticoids and plasmapheresis has been successful in controlling the manifestations of her disease.
Cyclophosphamido: Studio Clinic
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal