tbuckley/cabot-search huggingface dataset:
Abstract 2222: Oncogene-mediated alterations in chromatin conformation
Authors: David S. Rickman, T. David Soong, Benjamin Moss, Juan Miguel Mosquera, Jan Dlabal, Stephane Terry, Theresa MacDonald, Karen Bunting, Francesca Demichelis, Ari Melnick, Olivier Elemento, Mark A. Rubin
Journal: Cancer Research (2012)

Abstract Emerging evidence suggests that chromatin adopts a non-random three dimensional (3D) topology and that the organization of genes into structural hubs and domains affects their transcriptional status. How chromatin conformation changes in diseases such as cancer is poorly understood. Moreover, how oncogenic transcription factors, which bind to thousands of sites across the genome, influence gene regulation by globally altering the topology of chromatin requires further elucidation. To address these questions, we performed unbiased high-resolution mapping of intra- and inter-chromosome interactions upon over-expression of ERG, an oncogenic transcription factor frequently over-expressed in prostate cancer as a result of a gene fusion. By integrating data from genome-wide chromosome conformation capture (Hi-C), ERG binding and gene expression, we demonstrate for the first time that an oncogenic transcription factor can induce global, reproducible and functionally coherent changes in chromatin organization. We also show using spectral karyotyping that ERG over-expression is associated with a specific translocation involving chromosomes 13 and 15 at loci that are enriched in ERG binding. The results presented here have broader implications, as many driving genetic lesions in other cancer types involve altered levels of transcription factors due to genomic alterations (e.g. EWS-FLI1, c-Myc, n-Myc, PML-RARα). Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2222. doi:1538-7445.AM2012-2222
Gastric Pain
Authors: C. Miller
Journal: BMJ (1926)

GASTRIC PAIN.[TEDICAL JouL'ita 369 drung is cl-aimed-only to be an amoebicide, this-result is what might be expected.The other three preparations exhibit a common action, val-ying little in degree, which is of considerable interest.They destroy all B. coli in a dilution of 1 in 200, and a large proportion of B. coli at 1in 2,000.On the other hanid, they destroy only a proportion of streptococci at 1 in 200, and at 1 in 2,000 streptococci actually multiplv.This is a selective action paralleled by the well known propertv of phenol of inhibit- ilg the growth of B. coli in diltution of approximately 1 in 200, at which streptococci will grow vigorously, a property which has been found of considerable use in routtine bac- teriology.This suggests that all these three preparations are closely allied in action, and presumably in composition, to phenol.*To those who regard the predominance of streptococci in the faeces as accountable for chronic ailments such as arthritis, this action on the part of these drugs will hardly commend itself.But before applying such findings to the presumed effect of these drugs on the hiuman subject, it must be asked in what dilution thev were present in the iritestinal tract when taken in ordinary doses.This cannot bedetermined unless it is known whether they are absorbed,.combined, or destroyed, or unless a method be devised for estimating them in the faeces themselves.The latter, having in view that thieir composition is unstated, isr hardly feasible.But some indication as to their activity, if any, in the -colon may perhaps be obtained by com.paring the results of the two above series of experiments in rivo and int vitro respectivelv.The latter clearly show that in certain dilutions tlhree of these antiseptics exert a selective action on coliform bacilli.If; in experiments on the human subject, it were shown that although the total niumbers of organisms in the stools were unaffected the proportion of streptococci to coliforin bacilli was increased, it might be presumed that this change had been brought about by the actioni of the an-ti- septic, and therefore that its dilution in the bowel is sone- thling in the neighbourhood of 1 in 2,000.That this is probably not so is shown by the following figures, which refer to the same series of experiments as in Table I.TABLE III.-A vcrage Pcrecntagc of Streptococci in Facers btfjore and during Administration of "Intestinal Anitiseptics."Average Percenitage of Streptococci.Before After Antiseptic.Administration.
Commentaire du travail de Tsujii Y et al., pp. 775
Authors: Gilles Lesur
Journal: Endoscopy (2015)

See also: Clinical outcomes of endoscopic submucosal dissection for superficial esophageal neoplasms: a multicenter retrospective cohort studyEndoscopy 2015; 47(09): 775-783DOI: 10.1055/s-0034-1391844
Improvements in Workplace Safety—United States, 1900-1999
Journal: JAMA (1999)

At the beginning of this century, workers in the United States faced remarkably high health and safety risks on the job. Through efforts by individual workers, unions, employers, government agencies, scientists such as Dr. Alice Hamilton, and others, considerable progress has been made in improving these conditions. Despite these successes, much work remains, with the goal for all workers being a productive and safe working life and a retirement free from long-term consequences of occupational disease and injury. Using the limited data available, this report documents large declines in fatal occupational injuries during the 1900s, highlights the mining industry as an example of improvements in worker safety, and discusses new challenges in occupational safety and health.
TRAINING SCHOOLS FOR MALE NURSES.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Figures Transposed
Journal: JAMA (1977)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Excision of Major Duct System of the Breast
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nonseminomatous germ cell testicular tumors clinical stage II: Retroperitoneal lymph node dissection, chemotherapy or both?
Authors: T. Sava, S. Pessa, L. Nicoletti, A. Perin, A. P. Fraccon, F. Merlin, A. Rosa-Bian, V. Fosser, G. L. Cetto, T. Franceschi
Journal: Journal of Clinical Oncology (2004)

4746 Background: Patients (pts) with nonseminomatous germ cell testicular tumors (NSGCTT) clinical stage IIa and IIb can be treated with: retroperitoneal lymph node dissection (RPLND), RPLND followed by adjuvant chemotherapy (CT) or CT with surgery of residual masses. The optimal management for is still debated. Methods: We analyzed retrospectively 55 pts with NSGCTT clinical stage IIa (28) and IIb (27) followed in our Institutions. Median age was 29 (17–55) years. Embrional carcinoma (EC) was predominant in 40 (73%) pts. Serum tumor markers were elevated in 58% of the pts. Treatment was: RPLND in 7 IIa (3 resulted a I pathological stage) and in 2 IIb pts; RPLND and adjuvant CT (2 or 3 cycles of platinum based CT) in 12 IIa and in 5 IIb pts; CT alone (mainly 3 PEB) in 3 IIa and in 10 IIb pts; CT followed by RPLND for residual masses in 6 IIa and in 10 IIb. Median follow-up was 70 (5–202) months. Results: Relapses occurred in 3 pts (5%): all of them were IIb and with predominance of EC. Median time to relapse was 7 months (4–9); site of relapse were: retrocrural lymph nodes, lung and serum tumor marker only respectively. Two were initially treated with RPLND alone and at relapse platinum-based chemotherapy: both are alive and free from disease. One pt, treated at the beginning with RPLND and adjuvant CT (3 PEB), relapsed and despite any treatment died of disease. Conclusions: i) The preferred initial treatment was RPLND in pts with stage IIa and chemotherapy in pts with stage IIb; ii) false positive staging error was 16% in clinical stage IIa; iii) relapse can occur, particularly in pts with IIb (11%) and EC predominance (7.5%), quite soon and in different sites; iv) no one pts treated primarily with 3 PEB relapsed; v) more than 98% ot the pts are alive and disease-free irrespectively of treatment option: histology, clinical stage and patient's preferences should be part of the decision making. No significant financial relationships to disclose.
Cocaine Hydrochlorate.
Journal: JAMA (1884)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Measurement of Organophosphate Metabolites in Postpartum Meconium as a Potential Biomarker of Prenatal Exposure: A Validation Study
Authors: Robin M. Whyatt, Dana B. Barr
Journal: Environmental Health Perspectives (2001)

Experimental data have linked exposure to prenatal organophosphates to adverse neurocognitive sequalae. However, epidemiologic research has been hampered by lack of reliable dosimeters. Existing biomarkers reflect short-term exposure only. Measurements of pesticides in postpartum meconium may yield a longer-term dosimeter of prenatal exposure. As the initial step in biomarker validation, this research determined background levels, detection limits, and stabilities of six organophosphate metabolites in meconium: diethylphosphate (DEP), diethylthiophosphate (DETP), diethyldithiophosphate (DEDTP), dimethylphosphate (DMP), dimethylthiophosphate (DMTP), and dimethyldithiophosphate (DMDTP). Calibration curves were also constructed. The meconium was collected from 20 newborns at New York Presbyterian Hospital; analyses were undertaken at the Centers for Disease Control and Prevention (CDC). DEP was detected in 19/20 samples (range 0.8-3.2 microg/g) and DETP was detected in 20/20 (range 2.0-5.6 microg/g). DMP and DEDTP were each detected in 1/20 (at 16 and 1.8 microg/g, respectively). DMTP and DMDTP were not detected. Detection limits were comparable to or lower than those in urine; levels were similar to those seen in adult urine in population-based research. Metabolites were stable at room temperature over 12 hr. Calibration curves were linear over the range tested (0.5-400 microg/g); recoveries ranged from 18% to 66%. Using isotope dilution, recoveries of each analyte in individual samples can be corrected automatically based on the recovery of the respective stable isotope-labeled analogue, making this method fully quantitative. Results indicate that measurements of organophosphate metabolites in meconium have promise as biomarkers of prenatal exposure. Further research is needed to determine the time frame of exposure represented by pesticide levels in meconium and to evaluate the dose-response relationship.
Public health strategies for confronting AIDS. Legislative and regulatory policy in the United States
Authors: L. O. Gostin
Journal: JAMA (1989)

THE acquired immunodeficiency syndrome (AIDS) epidemic poses a serious threat to public health, but its impact goes far beyond health. The burden of disease falls predominantly on disfavored populations—intravenous drug users, homosexuals, and prostitutes. Moreover, racial minorities are disproportionately represented in these groups.<sup>1,2</sup> Many argue that governmental and public health officials have failed to implement strong measures in deference to the civil liberties of high-risk groups.<sup>3</sup>Others argue that society has overreacted to the epidemic and imposed penalties and discriminatory treatment that would never have occurred if the primary targets of intervention were more popular.<sup>4</sup>Not surprisingly, these two contradictory viewpoints are espoused by groups at opposite ends of the political spectrum. A deeper dimension of the AIDS epidemic, then, is political, and it is manifested in legislation. The volume and content of state AIDS legislation has increased considerably since earlier reports.<sup>5,6</sup>Legislation related to AIDS
Highlights
Journal: JAMA Neurology (2019)

There are at least 9 hereditary neurodegenerative polyglutamine diseases; however, many individuals who are carriers of polyglutamine disease-associated alleles are not symptomatic and therefore remain undiagnosed.In an observational cross-sectional study using data from 5 European studies that included DNA samples from more than 14 000 participants without a known polyglutamine disease diagnosis, Gardiner and coauthors found that the prevalence of intermediate alleles was 10.7% and that the prevalence of pathological alleles was 1.3%.The prevalence of carriers with intermediate and pathological ranges of polyglutamine disease-associated gene variants is considerably higher than previously estimated, suggesting that a larger portion of the population might be at risk of developing a clinical polyglutamine disease.Editorial perspective is provided by Hammer and Singleton.
Beyond Reason
Authors: Lala Tanmoy Das
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Systemic Sporotrichosis
Authors: PETER J. LYNCH
Journal: Annals of Internal Medicine (1970)

Four patients with systemic sporotrichosis are presented. All were adult men, and two were alcoholics. One patient had Hodgkin's disease, and another had multiple myeloma; both had widespread sporotrichotic infection, suggesting that development of multifocal systemic sporotrichosis is related to the role of Sporothrichum schenckii as an opportunistic invader. Characteristic cutaneous, pulmonary, and articular lesions occur in systemic sporotrichosis; erythrocyte sedimentation rates are elevated, and white blood cell counts are near normal. The prognosis is good in unifocal systemic sporotrichosis, but death may occur when the disease is multifocal. In both types of involvement intravenous amphotericin B is superior to iodide therapy. We emphasize that sporotrichosis should be considered a bona fide member of the systemic fungal diseases, that "opportunistic" infection occurs and may be responsible for an increasing frequency of disseminated systemic infection, and that diagnosis depends on the recognition of the characteristic cutaneous and joint involvement together with repeated multiple fungal cultures.
The role of RIPK3 in non-alcoholic fatty liver disease: a multi-omics perspective
Authors: Miguel Mateus-Pinheiro, Marta B. Afonso, Pedro Miguel Rodrigues, André L. Simão, Maria Manuela Gaspar, Sylvaine Di-Tommaso, Anne-Aurélie Raymond, Jean-William Dupuy, Frederic Saltel, Rui E. Castro, Cecília M.P. Rodrigues
Journal: Journal of Hepatology (2020)
Incorrect Text
Authors: Kevin Riggs, Matthew Decamp
Journal: JAMA (2015)

Barbara P. Yawn, MD, MSc, MSPH; George R. Buchanan, MD; Araba N. Afenyi-Annan, MD, MPH; Samir K. Ballas, MD; Kathryn L. Hassell, MD; Andra H. James, MD, MPH; Lanetta Jordan, MD, MPH, MSPH; Sophie M. Lanzkron, MD, MHS; Richard Lottenberg, MD; William J. Savage, MD, PhD; Paula J. Tanabe, PhD, RN; Russell E. Ware, MD, PhD; M. Hassan Murad, MD, MPH; Jonathan C. Goldsmith, MD; Eduardo Ortiz, MD, MPH; Robinson Fulwood, PhD, MSPH; Ann Horton, MS; Joylene John-Sowah, MD, MPH
Malaria in Somalia: lessons in prevention
Authors: E. Ledbetter
Journal: JAMA (1995)

<h3>To the Editor.</h3> —In the article assessing malaria in US Marines returning from Somalia by Dr Newton and colleagues,<sup>1</sup>important issues regarding prevention may be obscured by their finding that 50% of patients were administered suboptimal chemoprophylaxis. The Navy Environmental and Preventive Medicine Unit No. 5 identified 132 cases of Somalia-related malaria in 128 marines. Ninety-seven individuals were interviewed.<i>Plasmodium vivax</i>accounted for 82 (65.1%) of 126 diagnoses, 34 (27.0%) were<i>Plasmodium falciparum</i>, eight (6.3%) were mixed, and two (1.6%) were unspeciated. Malaria exposure had been anticipated<sup>2</sup>and preparations made. Appropriate prescribing is published in the widely distributed<i>Navy Medical Department Guide to Malaria Prevention and Control</i>.<sup>3</sup>For doxycycline, 89 (89.9%) of 99 prescriptions were appropriate, as were 81 (92.0%) of 88 primaquine prescriptions. For mefloquine, 59 (71.1%) of 83 were appropriate. The other 24 (28.9%) included many that failed to overlap doxycycline and mefloquine by 1
Cerebellar and Cerebral Gliomas Occurring in the Same Individual
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal