tbuckley/cabot-search huggingface dataset:
HIV
Journal: JAMA (1999)

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Highlights
Journal: JAMA Psychiatry (2018)

Association of History of Depression With Risk for Lupus 1225The etiology of depression is still elusive and a matter of debate; however, inflammation and autoimmune processes have been proposed as 1 pathophysiologic pathway.In this cohort study of 194 483 women, Roberts and colleagues examined the temporal association between systemic lupus erythematosus (SLE) and depression and found a 2-fold increase of SLE in those women who had a history of depression.Thus, depression may change inflammatory processes and set the stage for the subsequent emergence of autoimmune diseases.Continuing Medical Education jamanetwork.com/learning Myocardial Infarction Treatment and Mortality in Schizophrenia 1234Patients with schizophrenia have an excess cardiovascular mortality, but to our knowledge, no studies have investigated whether taking recommended treatments reduces this mortality.In a nationwide cohort of 105 018 patients with myocardial infarction, Kugathasan and colleagues showed that patients diagnosed with schizophrenia who did not receive cardioprotective treatment had the highest mortality rate, followed by treated patients diagnosed with schizophrenia and then by the general population.Thus, administration of proper cardiovascular treatment can reduce some of the increased cardiac mortality among patients with schizophrenia.In an Editorial, Druss discusses implications for the field.
Relation between Severe Illness and Non-Completion of Quality-of-Life Questionnaires by Patients with Rectal Cancer
Authors: Ina Kopp, Wilfried Lorenz, Matthias Rothmund, Michael Koller
Journal: Journal of the Royal Society of Medicine (2003)

Quality of life (QoL) is an important outcome measure in clinical studies, but interpretation is hindered by incompleteness of data. We addressed this issue in a population-based cohort study of 146 patients with newly diagnosed rectal cancer. QoL was assessed by means of European Organization for the Research and Treatment of Cancer questionnaires at discharge from hospital after primary treatment and then every 3 months for 2 years. In parallel, objective clinical data were documented. Analyses were conducted in three steps: participants versus non-participants with QoL-assessment; poor compliers who filled in only one or two questionnaires ( n=20) versus good compliers who filled in all or nearly all questionnaires ( n=18); and the proportion of missing forms and critical (very poor) QoL scores in risk patients versus non-risk patients over the course of 2 years. Non-participants and poor compliers were older, were more likely to receive palliative (rather than curative) treatment, and had worse scores for physical status. Tumour progression and therapeutic interventions were more frequent in poor compliers than in good-compliers. Patients with risk factors (age &lt;75 years, poor physical status, palliative treatment) were more likely to have missing questionnaires and critical QoL scores in respect of physical functioning and global quality of life over the course of 2 years. Missing values for QoL have clinical as well as methodological implications, because QoL scores can enhance a clinician's insight. Unwillingness to fill in a questionnaire is an indicator of serious illness. Studies that report sample statistics without specifying compliance rates and the characteristics of non-compliers will give a misleadingly positive picture.
Special Studies
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Marriages
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Physical activity and the risk of developing pancreatic cancer - data from a UK prospective study (EPIC-NORFOLK)
Authors: P. J. R. Banim, R. Luben, K.-T. Khaw, N. Wareham, A. R. Hart
Journal: Gut (2011)

<h3>Introduction</h3> Physical activity may reduce the risk of developing pancreatic cancer by preventing weight gain and improving glucose tolerance and insulin sensitivity. Previous epidemiological investigations of physical activity in large cohort studies have reported inconsistent results, although many showed no associations. The aim of this UK prospective cohort study was to investigate physical activity assessed by a questionnaire validated against detailed physiological measurements. <h3>Methods</h3> A total of 25 639 participants (56% women) aged 40–74 years were recruited into the European Prospective Investigation into Cancer-Norfolk (EPIC-Norfolk). Participants attended a health check at enrolment where weight and height were recorded and they completed a questionnaire, which recorded occupational and recreational physical activity, which had been validated, firstly against energy expenditure (assessed by 4-day heart rate monitoring), and secondly cardio-respiratory fitness (assessed by sub-maximal oxygen uptake).From the questionnaire participants were classified into four groups of physical activity: active, moderately active, moderately inactive and inactive. The cohort was then monitored for 16 years and cancer registry data used to identify those who subsequently developed pancreatic cancer. A cohort analysis was performed using Cox regression modelling to estimate the hazard ratios (HR) for developing pancreatic cancer for each category of physical activity, adjusted for age, gender, smoking status, body mass index and diabetes. <h3>Results</h3> A total of 93 participants (52.6% women, mean age of diagnosis=72.2 years (SD=9.0 years)) developed pancreatic cancer with 77% having advanced disease. The interval between recruitment and diagnosis was 8.6 years (SD=3.7 years). No associations were found between increased physical activity and pancreatic cancer (active vs inactive HR=1.03, 95% CI 0.52 to 2.01, trend across categories HR=1.04 95% CI 0.84 to 1.28). <h3>Conclusion</h3> Physical activity was not associated with the risk of developing pancreatic cancer in a UK population, a result supported by most previous studies. The evidence is emerging that physical activity is not involved in the aetiology of pancreatic cancer.
Preliminary analysis of immune responses in patients enrolled in a Phase II trial of cyclophosphamide with allogenic dribble vaccine alone (DPV-001) or with GM-CSF or imiquimod for adjuvant treatment of stage IIIa or IIIb NSCLC
Authors: Rachel Sanborn, Brian Boulmay, Rui Li, Bradley Spieler, Kyle Happel, Christopher Paustian, Tarsem Mougdil, Zipei Feng, Christopher Dubay, Brenda Fisher, Yoshinobu Koguchi, Sandra Aung, Eileen Mederos, Carlo Bifulco, Michael McNamara, Keith S Bahjat, William Redmond, Augusto C Ochoa, Hong Hu, Bernard Fox, Walter Urba, Traci Hilton
Journal: Journal for ImmunoTherapy of Cancer (2015)

Meeting abstracts Tumor-derived autophagosomes, DRibbles, are DC-targeted microvesicles containing more than 100 putative NSCLC antigens, many as potential altered-peptide ligands (APL), which could increase their immunogenicity. The microvesicles also contain at least 15 DAMPs with agonist
Residency Overwork
Authors: John W. Frost
Journal: Annals of Internal Medicine (1996)

Letters15 May 1996Residency OverworkJohn W. Frost, MDJohn W. Frost, MDFreeport, IL 61032Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-124-10-199605150-00036 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Medical residents have been overworked for years and will continue to be so. They are burdened with routine matters that attending physicians feel are below their dignity. Until physicians give their time to resident education, advisory relationships will continue. As usual, it is the patients who suffer.I enjoyed my rotating internship and years as an internal medicine resident at the Hospital of the University of Pennsylvania. Some attending physicians introduced the residents as their associates. Others treated us as serfs or slaves, rarely introduced us, and often referred to us as “my intern,” “my resident,” or ...References1. Peabody FW. The care of the patient. JAMA. 1927; 88:877-82. Google Scholar2. Green MJ. What (if anything) is wrong with residency overwork? Ann Intern Med. 1995; 123:512-7. Google Scholar3. Griner PF. Residency overwork and changing paradigms of service [Editorial]. Ann Intern Med. 1995; 123:547-8. Google Scholar Author, Article, and Disclosure InformationAuthors: John W. Frost, MDAffiliations: Freeport, IL 61032 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 May 1996Volume 124, Issue 10Page: 933KeywordsHospital medicinePatient advocacyResidency ePublished: 15 August 2000 Issue Published: 15 May 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Coronary-prone individuals (type A behavior pattern). Growth hormone responses
Authors: M. Friedman
Journal: JAMA (1971)

The average resting and after arginine hydrochloride infusion plasma growth hormone concentrations of relatively coronary-prone subjects (persons with type A behavior pattern) were found to be significantly lower than those of relatively coronary-resistant individuals (subjects with type B behavior pattern). This difference does not appear to be a fixed one, but is related to the intensity of the behavior pattern present at the time of study.
IMPRISONMENT AT HARD LABOR AND TYPHOID FEVER.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Neuropathology
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 057: Towards an Optimal Exercise Strategy for Reversing Low Cardiorespiratory Fitness: Distinct Effects of Exercise Volume and Intensity
Authors: Sara Giovannetti, John Clarke, Gifferd Ko, Einat Shalev-Goldman, O’Neill Trevor, Miu Lam, Robert Ross
Journal: Circulation (2013)

Although a majority of adults increase cardiorespiratory fitness (CRF; VO2 peak) in response to an increase in daily physical activity, the optimal exercise strategy for reversing low CRF is unknown. We performed a randomized, controlled trial designed to study the separate effects of habitual exercise differing in dose (energy expenditure, kcal/session) and intensity (relative to VO2max) on CRF. We randomly assigned sedentary, abdominally obese men and women to one of the following 4 conditions: 1) No-exercise control (C), 2) Low volume, low intensity exercise (LVLI: 180 [[female symbol]] and 300 [[male symbol]] kcal @ 50% VO2 peak), 3) High volume, low intensity exercise (HVLI: 360 [[female symbol]] and 600 [[male symbol]] kcal @ 50% VO2 peak), 4) High volume, high intensity (HVHI: 360 [[female symbol]] and 600 [[male symbol]] kcal @ 75% VO2 peak). All participants were required to exercise under supervision 5 times per week for 24 weeks. Adherence to exercise averaged 95% across groups. Exercise dose and intensity achieved was not different from that prescribed regardless of group. The minutes exercised per session were 30±7 in LVLI, 51±16 in HVLI and 36±11 in HVHI. A marked variability in CRF response to exercise was observed independent of group (Figure). Compared to controls, CRF increased within all exercise conditions (P&lt;0.05). However, the CRF increase within the HVHI group (0.61±0.30L/min) was greater than both the HVLI (0.42±0.32L/min) and LVLI (0.26±0.28L/min) groups (P&lt;0.05). Thus, despite matching exercise volume within the HVHI and HVLI groups, exercise at 75% of VO2peak was associated with a marked increase in CRF by compared to exercise at 50%. Given that the time required to achieve the energy expenditure within the HVHI group was 30% less than the HVLI group (36 vs 51 min), these findings have important implications for allied health professionals seeking options for prescribing exercise to improve a major risk factor for morbidity and mortality, cardiorespiratory fitness.
pasture
Authors: Cornelius Gropp
Journal: JAMA (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Immune activation caused by vascular oxidation promotes fibrosis and hypertension
Authors: Jing Wu, Mohamed A. Saleh, Annet Kirabo, Hana A. Itani, Kim Ramil C. Montaniel, Liang Xiao, Wei Chen, Raymond L. Mernaugh, Hua Cai, Kenneth E. Bernstein, Jörg J. Goronzy, Cornelia M. Weyand, John A. Curci, Natalia R. Barbaro, Heitor Moreno, Sean S. Davies, L. Jackson Roberts, Meena S. Madhur, David G. Harrison
Journal: Journal of Clinical Investigation (2016)

During the assembly of Figure 10B, incorrect flow cytometry panels were inadvertently included for the Tg sm/p22phox + tempol sample.In addition, a different replicate is now provided for the Tg sm/p22phox sample in Figure 10A.The correct figure panels are below.
Lectures on Hernia and its Radical Cure
Authors: J. Wood
Journal: BMJ (1885)

Operation by the Subcutaneous Jfethod.-Causes of Failure in the Opera- tion.-Summary of Cases of Inguinial HIerntia operated on for Radical Cure.-Successes and Failures of the Operation.-Tableojascertained Duration of Curc.-Number of ascertainedI Failures.-HerniaCom- plicated with Undeseended Testis.-Transplantation of TestisintoScrotum.-Formation of " Tunica Vaginalis."IN the subcutaneous miiethod of operating, an inicision is made in the upper part of tho scrotum, where the tegumentary structures are so movable and elastic that the incision can, if necessary, be drawii up- wards, so as to expose the superficial abdoominal ring; and can be enlarged, if it be desiiable to remove the sac, to ani extent sufficient for this purpose.The length of this incision rarely exceeds, when tension is removedl and the dartos has resumed its normal degirce of contraction, one and a half to two inches.It will now be easy to detect with the finger the pillars of the superficial ring, the lower border of the internal obliqlue and transversalis muscles, the borders of the deep ring, the spermatic cord, and the outer edge of the rectus abdominis muscle.The finger can be passed into the deep ring, so as to raise forward the internal oblique and transversalis muscles, and feel internally the raised edge of the conjoined tendon.The first material I employed in stitching up the canal was hempen thread, fastened over a wooden compress.This was used in seventeen eases.In the small cases of children, a pair of rectangular pins, similar to hare-lip pins at the point, but bent at a right angi near the other end, with a loop like that of a safety-pin, to lock into its fellow, were used (in forty-eight cases).Then stout copper-wire, silvered, was employed, with a view to prevent suppuration, and to afford a straight diiection to the track, so as to drain tlhe part effectually (in two hun- dred and forty cases).Latterly, I have used a stout piece of kangaroo, deer, or ox-tendon, well antisepticised in carbolised oil, and softened just before Using by soaking in 1 to 40 carbolic lotion.The advantage of this is, that there is no necessity for disturbing the wound by removing the buried suture, as in the case of the wire and other methods.All these modifications are essentially alike as regards the structures ; MIMI, 18 UUIVOLL LU KUUFiSKLb ----.,. .
Toxicology testing requirements and the U.S.–Japan Collaborative Study on in vitro tests for chromosomal aberrations
Authors: M. D. Shelby, T. Sofuni
Journal: Environmental Health Perspectives (1991)

As part of the U.S.–Japan Agreement on Cooperation in Research and Development in Science and Technology, Japanese and American scientists met in North Carolina to exchange information on toxicology testing requirements and guidelines in the two countries and to review progress in a collaborative study on detection of chemically induced chromosomal aberrations in cultured mammalian cells.