tbuckley/cabot-search huggingface dataset:
Efficacy of everolimus plus octreotide LAR in patients with advanced neuroendocrine tumor and carcinoid syndrome: final overall survival from the randomized, placebo-controlled phase 3 RADIANT-2 study
Authors: M.E. Pavel, E. Baudin, K.E. Öberg, J.D. Hainsworth, M. Voi, N. Rouyrre, M. Peeters, D.J. Gross, J.C. Yao
Journal: Annals of Oncology (2019)

Ann Oncol 2017; 28(7): 1569–1575 (doi: 10.1093/annonc/mdx193) The following funding information has been added: “This work was supported in part by The University of Texas MD Anderson Cancer Center Support Grant P30 CA016672.” Efficacy of everolimus plus octreotide LAR in patients with advanced neuroendocrine tumor and carcinoid syndrome: final overall survival from the randomized, placebo-controlled phase 3 RADIANT-2 studyAnnals of OncologyVol. 28Issue 7PreviewIn the phase 3 RADIANT-2 study, everolimus plus octreotide long-acting repeatable (LAR) showed improvement of 5.1 months in median progression-free survival versus placebo plus octreotide LAR among patients with advanced neuroendocrine tumors associated with carcinoid syndrome. The progression-free survival P-value was marginally above the prespecified threshold for statistical significance. Here, we report final overall survival (OS) and key safety update from RADIANT-2. Full-Text PDF Open Archive
Regional Curarization
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Neuroendocrinology
Authors: Seymour Reichlin
Journal: New England Journal of Medicine (1963)

A THREAD of neuroendocrine theory runs through much of the history of medical science: emotional states were once identified with the Galenic humors, choler, bile and phlegm; Vesalius viewed the third ventricle, infundibulum ("funnel") of the hypothalamus and the pituitary gland as the pathway by which animal spirits drained to form nasal mucus ("pituita"); and the Cartesian interpretation of the mind-body problem centered upon a pineal soul. These early speculations provide a literary if not rigorous approach to the subject. Modern views of neuroendocrine relations had to await modern ideas of endocrine function dominated by the pituitary gland as "conductor . . .
Corrigenda
Journal: BMJ (1942)

BRITISHCtax liability is on Lx only, because the value of the board and lodging is not chargeable.But if the terms of the agreement provide for a sdlary of Lx but authorize the employer to make deductions (which we will assume amount to Ly for the year) on account of board and/or lodging supplied, then as Lx is the amount of the salary that is the amount assessable, and the employee has no right to deduct Ly from it.The leading case on the question, Cordy v. Gordon, was decided in 1925.
Heart-Sound Screening in Children
Authors: Robert E. Durnin
Journal: JAMA (1968)

The heart sounds of 3,797 school children were analyzed by a new portable analog-digital computer. A small microphone and bipolar electrocardiographic timing leads are the only inputs required from the patient. Heart sounds are analyzed on a beat-by-beat basis. The data are displayed on digital counters and are recorded as within normal limits (WNL) or outside normal limits (ONL) of the computer's programmed analyzing circuitry. Eighteen percent of the 3,797 students were examined by pediatric cardiologists. Sixteen cases of heart disease and two cases of conduction disturbances were detected by the computer. Half of the heart disease cases were previously unknown. No known cases of heart disease were missed by the computer. The false-positive ratio was 5.6%. Immediate analysis of heart sounds offers advantages over the tape-recording method of screening.
Burns. II. Initial treatment
Authors: J. A. Moncrief
Journal: JAMA (1979)

SMALL or superficial burns can be successfully managed by any modality, but larger thermal injuries and deep burns require special attention and a thorough understanding of the pathophysiology involved to minimize morbidity and mortality. <h3>Initiation of Treatment</h3> The initial treatment of the burn patient can be conveniently divided into several segments. Priorities are determined by the demands of the individual situation, and in actual practice all of the treatment approaches are being accomplished essentially simultaneously. These include sedation, the insertion of a urinary catheter to measure the amount and character of urine, the administration of tetanus prophylaxis, the use of antibiotics (if indicated), the institution of intravenous (IV) fluid resuscitation therapy, and the initial treatment of the local wound itself. Baseline blood counts, arterial blood gas levels, and pH measurements are routine requirements. <h3>Sedation</h3> Because of the fluid translocations that occur immediately following thermal injury and progress for several hours
WAR CORRESPONDENCE.
Authors: NICHOLAS SENN
Journal: JAMA (1898)

The beating of the drum, the measured tread of an armed host are again heard throughout the land and have aroused the patriotic spirit of the American people. For a fifth time our nation is face to face with a war the gravity of which it is impossible to estimate at the present time. The first war brought us our liberty and independence; the second established our reputation on the sea; the third taught our Mexican neighbor respect for our country; the fourth saved the Union, and the fifth, which is now being waged, was provoked in the cause of humanity. For centuries the beautiful neighboring island of Cuba has been in the greedy grasp of a foreign nation. The people to whom this gem of the ocean belongs have been downtrodden, tyrannized over and abused by the cold iron hand of an effete monarchy. The humane liberty-loving people of
CYSTIC FIBROSIS
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
<i>Circulation</i> : Clinical Summaries
Journal: Circulation (2012)

The clinical significance of the interaction between clopidogrel and proton pump inhibitors (PPIs) remains unclear.We examined the relationship between prior PPI use and 1-year cardiovascular events in patients with acute coronary syndrome randomized to clopidogrel or ticagrelor in a prespecified, nonrandomized subgroup analysis of the Platelet Inhibition and Patient Outcomes (PLATO) trial.The use of a PPI was independently associated with a higher rate of cardiovascular events in patients with acute coronary syndrome receiving clopidogrel; however, a similar association was observed between cardiovascular events and PPI use during ticagrelor treatment and with other non-PPI gastrointestinal treatment.Therefore, in the PLATO trial, the association between PPI use and adverse events may be due to confounding, with PPI use more of a marker for, than a cause of, higher rates of cardiovascular events.With recognition of the inherent limitations of nonrandomized comparisons, our findings do not support the need to avoid concomitant PPI use with clopidogrel or ticagrelor.See p 978.
Emotional Stress Can Aggravate But Not Cause Allergic Reactions
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
HM15211, a novel GLP-1/GIP/Glucagon triple-receptor co-agonist significantly reduces liver fat and body weight in obese subjects with non-alcoholic fatty liver disease: A Phase 1b/2a, multi-center, randomized, placebo-controlled trial
Authors: Manal Abdelmalek, Jaeduk Choi, Youngmin Kim, Kyounghee Seo, Marcus Hompesch, Seungjae Baek
Journal: Journal of Hepatology (2020)
The Physician and His Patient— A Case of Failure to Follow Orders
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Scoring system identifies asthma in patients with persistent cough
Journal: BMJ (1998)

Early discharge after surgery for breast cancer may be beneficial Shorter hospital stays are a new trend in surgery.Bonnema et al (p 1267) studied the effects of early discharge from hospital after surgery for breast cancer in a randomised trial of 125 women.Satisfaction with the shorter stay was high, and the duration of drainage from the axilla and the incidence of wound complications did not differ in those who were discharged early and those who remained until their drain was removed.The experience of psychosocial problems was similar in the two groups, as were the coping strategies used.Women who had shorter hospital stays were more likely to discuss their illness with their family.
Questions about grilling.
Journal: Environmental Health Perspectives (1996)

Unless we realize that the technologies we are dealing with are of international consequence, that the technologies are very serious, we are headed down a very dangerous and possibly disastrous path.Robert P. Gale, on nuclear power accidents such as Chernobyl USA Today, 27 April 1988 Questions about GrillingAccompanying each savory morsel of charbroiled meat are cancer-causing heterocyclic amines (HCAs).New studies indicate that HCAs may be involved in diseases such as cardiomyopathy, mammary cancers, and colon cancer.Even the fumes of cooked meats contain HCAs, which may pose respi- ratory risks for those who don't eat meat.HCAs, formed during cooking when naturally occurring amino acids in meat react with muscle creatine, are among the most potent mutagens and carcinogens known.In a recent study completed at York University in London and the Lawrence Livermore National Laboratory (LLNL) in Livermore, California, when patients scheduled for colon surgery were given trace doses of radiolabelled HCAs (equivalent to the amount in four well-cooked, quarter-pound hamburgers) beforehand, minute amounts were recov- ered from DNA in the tissue removed during surgery."Even at these small levels, the car- cinogen binds to DNA, showing how powerful it is," said Mark Knize, a biomedical sci- entist at the LLNL.Early investigations of the health risks of HCAs have focused on ingestion as the pri- mary route of human exposure and the colon as the primary target.Recent animal studies Food for thought.Grilling meats releases heterocyclic potent animal carcinogens and may play a role in canc suggest that HCAs target other organs as well.In rats, HCAs trigger cardiomyopathy, the inflammation and deterioration of heart tissue that occurs with age.The primary cause of human cardiomyopathy remains unknown, but, 'dietary factors like HCAs may play a role," says Elizabeth Snyderwine, chief of the Chemical Carcinogenesis Section at the National Cancer Institute.Snyderwine and colleagues Richard Adamson and Unnur Thorgeirsson noticed that monkeys with HCA-induced liver cancer also developed an unexpectedly high inci- dence of degenerative heart damage.When
Combined Effect of Cigarette Smoke and Mineral Fibers on the Gene Expression of Cytokine mRNA
Authors: Yasuo Morimoto, Tohru Tsuda, Hajime Hori, Hiroshi Yamato, Akira Ohgami, Toshiaki Higashi, Nobuhiko Nagata, Masamitsu Kido, Isamu Tanaka
Journal: Environmental Health Perspectives (1999)

To investigate which parameters are stimulated by mineral fibers and whether cigarette smoke enhanced a fiber-induced response, we examined the level of cytokine mRNA from alveolar macrophages (AMs) and lungs of rats exposed to mineral fibers and cigarette smoke in vivo. Male Wistar rats were given a single intratracheal instillation of 2 mg of Union Internationale Contre le Cancer chrysotile or refractory ceramic fiber (RF1). The animals then inhaled a side stream of smoke 5 days per week for 4 weeks. The expression of manganese superoxide dismutase, inducible nitric oxide synthase (iNOS), basic fibroblast growth factor (bFGF), interleukin-1[alpha] (IL-1[alpha]), interleukin-6 (IL-6), and tumor necrosis factor-[alpha] (TNF[alpha]) mRNA from lipopolysaccharide-stimulated AMs and lungs of rats exposed to mineral fibers and/or cigarette smoke were assessed using semiquantitative reverse-transcriptase polymerase chain reaction. Exposure only to cigarette smoke increased in IL-1[alpha] mRNA levels in AMs. Chrysotile stimulated the expression of IL-1[alpha], TNF[alpha], and IL-6 in AMs, and the expression of bFGF in lungs. RF1 resulted in increased expression of IL-1[alpha] and TNF[alpha] in AMs. Cigarette smoke stimulated the gene expression of iNOS in AMs and IL-6 and bFGF in lungs treated with chrysotile; IL-1[alpha] in AMs and bFGF in lungs did the same in lungs with RF1. Among these cytokines, message levels of IL-1[alpha], iNOS, and bFGF were increased in rats stimulated with mineral fibers, and the stimulating effects of mineral fibers were enhanced by cigarette smoke. Therefore, IL-1[alpha], iNOS, and bFGF would be the possible parameters of the lung remodeling induced by mineral fibers.
Cyanide intoxication among silver-reclaiming workers
Authors: P. Blanc
Journal: JAMA (1985)

Thirty-six former workers in a silver-reclaiming facility who had been exposed over a long-term to excessive levels of cyanide were studied to determine acute and residual toxic reactions. The study involved physical examinations, laboratory studies, and a questionnaire to determine levels of exposure, symptoms during employment, and current symptoms. Questionnaire data showed that during the time of active employment there was a high prevalence of symptoms that are consistent with acute cyanide toxic reactions. A significant positive trend for prevalence of cyanide-related symptoms measured against levels of exposure was demonstrated, supporting a dose-response effect. Some symptoms occurring seven or more months after exposure had ceased also exhibited a dose-response trend. Mild abnormalities of vitamin B<sub>12</sub>, folate, and thyroid function were detected and suggest long-term cyanide effects. (<i>JAMA</i>1985;253:367-371)
Presence of autonomic neuropathy is a poor prognostic indicator in patients with advanced liver disease
Authors: J FLECKENSTEIN
Journal: Hepatology (1996)

Autonomic neuropathy (AN) is seen in both alcohol-induced and non-alcohol-induced liver disease, and when present is an independent predictor of mortality. We postulated that patients who were awaiting liver transplantation are likely to have a high prevalence of autonomic neuropathy with an associated increase in mortality. To test our hypothesis, we evaluated the presence of autonomic neuropathy using a battery of tests in 33 patients awaiting liver transplantation and prospectively followed them to determine their prognosis. Twenty-two of 33 (67%) patients with liver disease had evidence of autonomic neuropathy; of these, 12 (36%) had evidence of definite and 10 (31%) had early autonomic neuropathy. The prevalence of AN was similar in alcohol-induced and non-alcohol-induced liver disease. Using Child-Pugh classification, 14.3% Child A, 31.3% Child B, and 60% Child C had definite autonomic neuropathy. Six patients died during a median observation period of 10 months, and all had AN. Kaplan-Meier survival analysis showed a significantly higher mortality (P=.05) in patients with AN. On the basis of this observation, we suggest that consideration should be given for early liver transplantation in patients with advanced liver disease and autonomic neuropathy.
The Treatment of Hyperthyroidism
Authors: E. M. Chapman
Journal: New England Journal of Medicine (1961)

THE proper treatment of a disease is usually based on the physician's knowledge of its natural course without treatment. Of hyperthyroidism such knowledge is lacking after long observation by physicians. I am intrigued in contemplating the possible contribution of faith healers to the natural history of this disease, as well as others. There is only 1 report in the medical literature of observations on the course of hyperthyroidism treated by what are now considered nonspecific methods. The experience was that of an English clinician, W. Hale White,1 who after a long career in the nineteenth and twentieth centuries reported in . . .
Insulin pump treatment in insulin-dependent diabetes mellitus. Children, adolescents, and young adults
Authors: S. J. Brink
Journal: JAMA (1986)

Twenty-four children, teenagers, and young adults (8 to 26 years old) with insulin-dependent diabetes mellitus were treated with continuous subcutaneous insulin infusion (CSII). Criteria for using CSII included persistent high glycohemoglobin (GHb) values and/or wide swings in blood glucose values despite arduous efforts to improve glycemia. Thirty percent discontinued CSII. Improvement was significant by three months for GHb and blood glucose values, but plateaued thereafter. Only three patients attained a normal GHb value. No predictors for degree of control were identified. Diabetic ketoacidosis did not occur more frequently with CSII. Electromechanical problems with the devices, patient errors, or local skin problems occurred in 50% of patients, although none produced ketoacidosis or severe hypoglycemia. Dietary noncompliance and decreased intensive home monitoring were contributory factors. Better ways to predict success or failure are needed if normalization or even near-normalization is a goal of CSII in younger patients with insulin-dependent diabetes mellitus followed up in a nonresearch setting. (<i>JAMA</i>1986;255:617-621)
一项关于化脓性汗腺炎患者发生严重感染风险的研究
Authors: H.H. Lee, K.R. Patel, V. Singam, S. Rastogi, J.I. Silverberg
Journal: British Journal of Dermatology (2020)

化脓性汗腺炎 (HS) 或反常性痤疮是一种慢性皮肤病,0.3% 至 4.0% 的全球人口受其影响。HS 通常会影响人体的皮肤褶皱处(例如腋窝和腹股沟),并可能导致严重的炎症、疼痛、痒、疤痕和外形毁损。 研究人员位于美国。这项研究的目的是使用美国住院患者数据库 2002 年至 2012 年之间的国家住院样本,确定 HS 与各种严重感染之间是否存在关联。这项研究还调查了伴有严重感染 HS 患者的医疗费用和住院时间。 研究发现,HS 与影响皮肤、血液、肺、骨骼、关节、心脏和脑部的各种严重感染以及耐抗生素感染(意味着很难用抗生素治疗)的发生率较高有关。 伴有严重感染的 HS 住院患者(留在医院的患者)的住院时间较长,护理费用也更高。总而言之,这项研究发现 HS 与许多严重感染之间有很密切的相关性,包括显著增加的医疗费用和更长的住院时间。 本摘要涉及研究: 美国儿童和成人皮肤和皮外感染与化脓性汗腺炎的相关性
Refractory
Authors: Rebecca Foust
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal