tbuckley/cabot-search huggingface dataset:
Three Lectures on the Principle of Least Action in Nature, Illustrated by Animal Mechanics
Authors: S. Haughton
Journal: BMJ (1871)

Science ofAnimnal Afechanics defined as /he applica/tiont of the principles of Geomety anzd Mechantics to Comparative Anato;ty.-General Princille of Least Action, as observed in Astronomy anzd Physics.-Aftpli-cation of this principle to Animal Mechanics.-Zllustration of the Pleasures and Di0fculties ofthe Study of Animal Mechanics, fromt the Lectutrer's Adventures it Search ofthe Coet9cient of M'usculcar Force.I TAKE it for granted that there is no one of those whom I now address who has not read both with profit and pleasure Gulliver's Travels.But of the many thousands that have read that charm- ing book, there are very few that know the real circumstances of the history of its production.It is only a fragment of a much greater work which was contemplated and which the world has lost for ever- a work which was to have been the combined result of the genius of three of the most remarkable men that our country has produced; one an Englishman, another a Scotchman, the third an Irishman.More than 150 years ago, in the good old times when Queen Anne reigned in England, and science, literature, and art were patronised by her court, three of the most remarkable men that ever livled in this city were friends and companions.The Englishman was Pope, the Scotch- man was Arbuthnot, and the Irishman-I may be permitted as a fellowcountryman to say, greater than either-was our illustrious Swift.It was proposed by Pope that a novel should be written by these three men, which would have been a novelty not only in that age of literature but in our own, by which the combined efforts of the genius of three such men should be brought to bear upon the production of a work of fiction.The fragments of that work of fiction remain at the end of the large editions of Pope's works unlder the name of Memoirs of Mar- tinus Scribler-us.Pope was to have taught Martinus Scriblerus literature, logic, and metaphysics; Dr. Arbuthnot was to have taken charge of his medical education and have brought him to Holland and Ger- many to study medicine; while Swift was to have written his travels.Guiiver's Travels were produced as a separate work by Swift in consequence of the troubles at the close of the reign of Queen Anne, which scattered this remarkable triumvirate.The travels that were originally intended to illustrate the life and memoirs of Scriblerus appeared under the name of, and are known to you all as, Gulliver's Travels.The accession of George I not only destroyed the prospect of the world seeing the memoirs and travels of Martinus Scriblerus, but it also lost for England the credit of producing a great work on Animal Mechanics.It can be shown from several passages in his writings, that Dr. Arbuthnot, wvho was himself a most skilful geometer and a most expert anatomist, had conceived the project of uniting these sister sciences of anatomy and geometiry in one great Acience, and so creating a new field for discovery, for thought, and for research.His appointment as court-
Bone imaging: radionuclide scan vs MRI
Authors: M. Moinuddin
Journal: JAMA (1990)

<h3>To the Editor.—</h3> With reference to the article "Musculoskeletal Applications of Magnetic Resonance Imaging [MRI],"<sup>1</sup>we offer the following comments. Page 2423 shows a metastatic lesion in the sacrum on MRI examination with a negative bone scan. However, the bone scan in the figure is an anterior view, which will not show a posterior lesion. That is why anterior and posterior views are performed routinely in bone scintigraphy. Similarly, on page 2425, a negative posterior view of the bone scan is presented, with a positive MRI scan showing a stress fracture of the right femoral neck. Bone scans show hip fractures almost exclusively on the anterior view; again, a wrong view was depicted. Although the article was published by the Council on Scientific Affairs, we were impressed by the lack of knowledge about bone scintigraphy. Indeed, MRI is an excellent imaging modality, but that does not mean the authors
Hepatic Gluconeogenesis/Glycolysis: Regulation And Structure/Function Relationships Of Substrate Cycle Enzymes
Authors: S. Pilkis
Journal: Annual Review of Nutrition (1991)

The objective of this review is to provide an overview of intermittent fasting regimens, summarize the evidence on the health benefits of intermittent fasting, and discuss physiological mechanisms by which intermittent fasting might lead to improved ...Read More
Single oral dose ampicillin-probenecid treatment of gnorrhea in the male
Authors: P. A. Kvale
Journal: JAMA (1971)

Single oral antibiotic treatments of gonorrhea have not been universally successful. However, in this study of men who acquired gonococcal urethritis in the Philippines, a single oral dose of 3.5 gm of ampicillin with probenecid resulted in only eight failures of 202 patients (4.0%). The same dose of ampicillin without probenecid resulted in 12 failures of 41 patients (29.3%). Furthermore, single oral doses as high as 7.5 gm of phenoxymethyl penicillin were associated with higher failure rates, even with probenecid. In addition, the incidence of post gonococcal urethritis remained high regardless of the dose and duration of treatment. Therefore, a single oral dose of ampicillin with probenecid appears as a reasonable alternative to the standard treatment of acute gonococcal urethritis in men. Phenoxymethyl penicillin, on the other hand, should not be used in the treatment of gonorrhea.
Crippled Children: Their Treatment and Orthopedic Nursing.
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Patient-Initiated Laboratory Testing: No Gatekeeper, No Kidding-Reply
Authors: Henry B. Soloway
Journal: JAMA (1991)

<h3>In Reply.—</h3> Dr Wolfe correctly argues that laboratory data constitute only a part of the diagnostic process and that such data must be integrated with other information to arrive at a diagnosis. But what patient-initiated laboratory testing is really about is (1) who should control information flow, (2) whether it is in the public interest to maintain monopolies on medical or other types of knowledge, and (3) whether consumers with disposable income and a desire for information—eg, pregnancy tests, cholesterol level, stool occult blood—should be denied that information because they are not smart enough to be trusted with test results. Bostwick et al are concerned about several interesting but irrelevant issues. The potential for abuse in patientinitiated testing is<i>real</i>, but not an issue. There is potential for abuse with many types of medical diagnostic and therapeutic procedures, eg, computed tomographic scans and hysterectomies. Few would argue that these procedures
AB0826 Imaging Modalities for the Classification of Gout: Systematic Literature Review and Meta-Analysis
Authors: A. Ogdie, W. Taylor, M. Weatherall, J. Fransen, T. Jansen, T. Neogi, H.R. Schumacher, N. Dalbeth
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Imaging techniques for the classification of gout have advanced significantly since previous classification criteria for gout were established. However, it is not clear whether such imaging techniques should be included in new classification criteria for gout. <h3>Objectives</h3> To examine the usefulness of imaging modalities in the classification of gout when compared to monosodium urate (MSU) crystal confirmation as the gold standard in order to inform development of new gout classification criteria. <h3>Methods</h3> We systematically reviewed the published literature concerning the diagnostic performance of plain film radiography, magnetic resonance imaging, ultrasound (US), conventional computed tomography, and dual energy computed tomography (DECT). We included only studies using MSU crystal confirmation as the gold standard for case definition of gout. Quality of the studies was assessed using the Quality Assessment of Diagnostic Accuracy Studies (QUADAS) tool. Data were pooled and summary test characteristics were calculated when more than one study examined the same imaging feature. <h3>Results</h3> Ten studies (7 manuscripts and 3 meeting abstracts) satisfied the inclusion criteria. Six studies examined US, three studies examined DECT and one examined X-ray features of the sternomanubrial joint. All of the studies met most of the quality indicators. All studies occurred in the secondary care setting, with mean gout disease duration of at least 7 years when reported. Three features were examined in more than one study: the double contour sign (DCS) on US, tophus on US, and MSU crystal deposition on DECT. The pooled (95% CI) sensitivity and specificity of US DCS were 0.80 (0.62-0.91) and 0.91 (0.62-0.98) respectively, of US tophus were 0.68 (0.42-0.86) and 0.97 (0.56-0.999) respectively, and of DECT were 0.91 (0.78-0.97) and 0.91 (0.81-0.96) respectively. <h3>Conclusions</h3> US and DECT show promise for gout classification but the few studies to date have been in patients with longstanding, established disease. The contribution of imaging over other clinical features for gout classification criteria requires further examination, particularly for those earlier in the course of their disease. <h3>Acknowledgements</h3> This study was funded by the American College of Rheumatology and the European Union League Against Rheumatism. We thank Janet Joyce for performing the literature search and Yihui Connie Jiang for administrative support. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.1774
Offering Advance Directives
Authors: Greg A. Sachs
Journal: Annals of Internal Medicine (1993)

Letters1 April 1993Offering Advance DirectivesGreg A. Sachs, MDGreg A. Sachs, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-118-7-199304010-00031 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Schneiderman and coworkers' [1] finding of the lack of effect of offering advance directives may be interpreted to mean that physicians should not bother discussing these issues with their patients. As the authors note, the sample size lacked adequate power to feel confident about a negative finding; the treatment cost question alone would have required a sample eight times greater. More important, both the experimental and control groups were cared for in hospitals where unusual efforts were made to elicit patient preferences regarding cardiopulmonary resuscitation. As clinical experience and at least one study indicate [2], the writing ...References1. Schneiderman LJ, Kronick R, Kaplan RM, Anderson JP, Langer RD. Effects of offering advance directives on medical treatments and costs. Ann Intern Med. 1992; 117:599-606. Google Scholar2. LaPuma J, Silverstein MD, Stocking CB, Roland D, Siegler M. Life-sustaining treatment: A prospective study of patients with DNR orders in a teaching hospital. Arch Intern Med. 1988; 148:2193-8. Google Scholar3. Kane RL, Bernstein L, Wales J, et al. A randomized, controlled trial of hospice care. Lancet. 1984; 1:890-4. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1993Volume 118, Issue 7Page: 573-574KeywordsAntibioticsBloodCardiopulmonary resuscitationDo not resuscitate ordersPalliative carePatientsRandomized trials Issue Published: 1 April 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
A REFINEMENT IN THE RADICAL OPERATION FOR TRIGEMINAL NEURALGIA
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Imaging end-points to predict response to IGF1R/IR inhibition in CRC models
Authors: Natalie J. Serkova, Erica L. Bradshaw-Pierce, Kendra M. Hasebroock, Andrea L. Merz, Todd M. Pitts, Gail S. Eckhardt
Journal: Clinical Cancer Research (2010)

Abstract This abstract is being presented as a short talk in Plenary Session 6. A full abstract is printed in the Proffered Abstracts section (PR9) of the Conference Proceedings.
Screening for, Monitoring, and Treatment of Chronic Kidney Disease Stages 1 to 3: A Systematic Review for the U.S. Preventive Services Task Force and for an American College of Physicians Clinical Practice Guideline
Authors: Howard A. Fink
Journal: Annals of Internal Medicine (2012)

This analysis suggests that one-time general consent is better than a gift model for addressing 5 central challenges that arise in the context of obtaining and storing human biological samples for future research. This conclusion supports the suggestion made in a recent Advance Notice of Proposed Rulemaking to incorporate one-time general consent for research with human biological samples into any revisions of the federal regulations.
Incorrect Words
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MEDICAL HIPPOPHILE
Authors: J. H. T.
Journal: JAMA (1960)

Not all horse doctors are veterinarians; at least not all horsey doctors are ecozoiatrists. M. Murray Nierman, an Associate of the American Academy of Dermatology and a professed reader of the<i>Archives of Dermatology</i>as well as the<i>Daily Racing Form</i>, has been victimized by dual loyalties, horses versus patients. The jacket of his recent literary effort,<i>Patients and Ponies</i>,<sup>1</sup>confesses inoculation with the horse racing bug while he was still a student in medical school. My parents had led me to believe that this sickness was an hereditary malady and essentially as stigmatizing as syphilis or atheism. Although<i>septicemia eohippus</i>(Gr.<i>hippos</i>, horse) is reported to be incurable, many of those afflicted find it a lingering malady. I should have noted earlier that neither Nierman's skill as a dermatologist nor the scars on his horsebitten soul penetrated as deeply as his talents for satire and affection for travesty.
A NEW MOTTO FOR THE "RECORD."
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Acne
Authors: D Ofri
Journal: Annals of Internal Medicine (2000)

On Being a Doctor6 June 2000AcneDanielle Ofri, MD, PhDDanielle Ofri, MD, PhDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-11-200006060-00013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail A young Navajo woman files silently into my office, making no eye contact. As she slips into the chair, errant strands of black hair spill across her face. Through the breaches, I catch glimpses of her rich dark skin riddled with the pockmarks of severe acne. Violently swollen pustules and angry red craters contort the architecture of her face. Her shoulders slope into her slight body, as if afraid to claim too much territory on their own. She contemplates the linoleum wordlessly. I am almost afraid to interrupt.I am not her regular physician. At this clinic, she has no ... Author, Article, and Disclosure InformationAffiliations: Corresponding Author: Danielle Ofri, MD, PhD, Department of Medicine, Bellevue Hospital, 462 First Avenue, New York, NY 10016; e-mail, [email protected]net. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 6 June 2000Volume 132, Issue 11Page: 919-920KeywordsAcneChartsDrugsHospital medicinePregnancyResidencyScarsStomachSurgeryVision ePublished: 15 August 2000 Issue Published: 6 June 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Abstract 3805: Artesunate reduces tumor growth in sunitinb-resistant renal cell carcinoma cells
Authors: Eva Juengel, Sascha Markowitsch, Holger H. Erb, Thomas Efferth, Axel Haferkamp
Journal: Cancer Research (2019)

Abstract Introduction: Renal cell carcinoma (RCC) is the most common cancer of the kidney. Due to therapy resistance effect of the approved compounds, like the tyrosine kinase inhibitor (TKI) sunitinib, is limited. Thus, new treatment approaches are urgently needed. Artesunate (ART) is derived from Traditional Chinese Medicine (TCM), showing anti-tumor activity, also in urologic tumors. However, little is known about the efficiency of ART on therapy-resistant RCC. Therefore, we investigated the effect of ART on sunitinib-resistant RCC cell lines. Material and Methods: Parental (=sensitive) and sunitinib-resistant (1 µM) RCC cell lines, KTC-26, A498, and Caki-1, were exposed to ART (1-100 µM) for 24, 48 and 72 hours. ART untreated cells served as controls. Tumor cell growth, proliferation, cell cycling and the expression of cell cycle regulating proteins were then evaluated. Aside, the appearance of apoptotic and necrotic effects was determined. Results: Exposure to different concentrations of ART significantly reduced the tumor cell growth and proliferation of parental and sunitinib-resistant cells in a time- and dose-dependent manner, compared to the controls. At the same time, exposure to ART resulted in a cell cycle arrest in the G0/G1 phase. Notably, this effect was more prominent in the sunitinib-resistant cells. G0/G1 phase elevation was associated with a decrease in the percentage of S and G2/M phase cells. The observed changes in cell growth and cell cycle phases were accompanied by distinct modulations of the cell cycle regulating proteins, indicating for an inhibitory regulation of ART through cell cycle arrest. Indeed, neither necrotic nor apoptotic effects events were detectable after ART treatment, corroborating this assumption. Conclusion: Due to our data we conclude that ART has anti-tumor effects not only in parental but also in sunitinib-resistant RCC cells. Thus, adding ART to the standard therapies might be a promising treatment strategy for patients with advanced RCC. Further investigations are necessary to verify our findings. Citation Format: Eva Juengel, Sascha Markowitsch, Holger H. Erb, Thomas Efferth, Axel Haferkamp. Artesunate reduces tumor growth in sunitinb-resistant renal cell carcinoma cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3805.