tbuckley/cabot-search huggingface dataset:
THE OCCURRENCE OF THE WIDAL REACTION IN JAUNDICE.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
What's Wrong with This Picture?
Authors: Samuel A. Brody
Journal: Annals of Internal Medicine (1998)

Letters15 February 1998What's Wrong with This Picture?Samuel A. Brody, MDSamuel A. Brody, MDBaldwin, NY 11510Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-4-199802150-00031 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:My thanks to Dr. Berkwits for his review of the possible association between aortic stenosis and idiopathic gastrointestinal bleeding. Such clinical “pearls” have been formally and informally taught by our profession since its inception. We can only hope that the current flood of guidelines and pathways will serve our patients as well.Dr. Gilbert raises three important issues: physicians complaining about lawyers, physicians' insecurity, and specialist compensation. Physicians complaining about lawyers or using the legal profession's foibles to, in some way, justify our own failings is embarrassing. Let's stop doing this. We are responsible for ourselves. We'd do ... Author, Article, and Disclosure InformationAuthors: Samuel A. Brody, MDAffiliations: Baldwin, NY 11510 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 February 1998Volume 128, Issue 4Page: 324KeywordsAnxietyHemorrhageMotivationRiversStenosis ePublished: 15 August 2000 Issue Published: 15 February 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Correction: Nonhypoglycemic Effects of Thiazolidinediones
Journal: Annals of Internal Medicine (2001)

Corrections21 August 2001Correction: Nonhypoglycemic Effects of ThiazolidinedionesFREESearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-135-4-200108210-00032 SectionsAboutVisual AbstractPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail In an article on nonhypoglycemic effects of thiazolidinediones (1), the second sentence under the heading “ Albuminuria” on page 66 should read “Although the exact mechanism of increased cardiovascular risk in microalbuminuria is unknown, it appears that several other cardiovascular risk factors increase in the presence of microalbuminuria and correlate with the degree of microalbuminuria.”References1. Parulkar AA, Pendergrass ML, Granda-Ayala R, Lee TR, Fonseca VA. Nonhypoglycemic effects of thiazolidinediones. Ann Intern Med. 2001;134:61-71. [PMID: 11187421] LinkGoogle Scholar Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoNonhypoglycemic Effects of Thiazolidinediones Akhil A. Parulkar , Merri L. Pendergrass , Ramona Granda-Ayala , Tri Richard Lee , and Vivian A. Fonseca Metrics Cited byThe role of PPARγ in chemotherapy-evoked pain 21 August 2001Volume 135, Issue 4Page: 307KeywordsMedical risk factorsMicroalbuminuria ePublished: 21 August 2001 Issue Published: 21 August 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
THE BOOKCASE
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Rubella Vaccination
Authors: Harry M. Meyer
Journal: JAMA (1971)

In 1969, in anticipation of the licensing of live rubella virus vaccine, we reviewed the data available from research work with attenuated rubella viruses and considered the prospects for controlling rubella through vaccination.<sup>1</sup>Looking ahead in this second year of rubella vaccine use, it is appropriate to pause and to reconsider our earlier comments in the light of the increased experience. Several questions pertaining to vaccine use arise frequently and will be dealt with in some detail. <h3>Vaccine Availability</h3> During an experimental phase extending from 1965 through 1969, approximately 100,000 persons were inoculated with various attenuated rubella virus preparations. At present, three manufacturers have been licensed in the United States to produce live rubella virus vaccine. These vaccines are HPV-77 DE5 (a derivative of the HPV-77 strain produced in duck embryo cell culture), HPV-77 DK12 (a derivative of the HPV-77 strain produced in dog kidney cell culture), and Cendehill
Editor's Choice
Journal: British Journal of Dermatology (2016)

Does psoriasis effect pregnancy outcomes?Bobotsis and colleagues from Canada explored psoriasis and pregnancy outcomes by a systematic review of observational studies.Th ey searched PubMed, Embase and the Cochrane database for published articles examining psoriasis and adverse pregnancy outcomes, and included observational studies and clinical trials evaluating direct measures of maternal and fetal morbidity and mortality.Four of the nine included articles reported a statistically signifi cant increase in the risk of at least one negative outcome, including spontaneous abortion, caesarean delivery, low birthweight, macrostomia, large-forgestational age, and a composite outcome consisting of both prematurity and low birthweight.However, these associations were not always consistent across studies.Th e authors concluded that, overall, there was no clear evidence of increased adverse outcomes in pregnant women with psoriasis.
Risk of Posttransfusion Hepatitis in the United States
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE CARDIO-VASCULAR SYSTEM AND ITS RELATIONS TO DISEASE.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Highlights from this issue
Authors: The Triumvirate
Journal: Thorax (2020)

The TriumvirateAs the festive season approaches, amidst COVID-19 restrictions, we harken back to the glory days of the Christmas single.For decades, the biggest names in popular music (as well as some unlikely contributors) have sought to cheer us up in the middle of winter whilst augmenting their personal bank accounts. CHRISTMAS WRAPPINGThe Waitresses, a new wave band from Akron Ohio, released their Christmas single "Christmas Wrapping" in 1982.The band's lead singer Patty Donahue delivered a cynical, alternative take on the Christmas season.Waitresses often rely on tips to maintain a decent wage and TIP/S is the subject of a paper in this month's Thorax by Heirali and colleagues (see page 1058).The TIP/S in question stand for tobramycin inhalation powder / solution, used in cystic fibrosis as a chronic suppressive therapy for pulmonary infection with Pseudomonas aeruginosa.The Thorax paper addresses the "off target" effects of TIP/S on the sputum microbiome.The authors analysed 151 sputum samples from 41 patients and conclude that the sputum microbiome remains stable during TIP/S therapy although the baseline microbiome may predict patient response to TIP/S.Sadly, The Waitresses disbanded in 1984 and lung cancer later claimed Patty Donahue as a result of smoking (as featured in the promotional video for the single).
PNEUMONIC FEVER—ITS SYMPTOMATOLOGY.
Authors: EDWARD F. WELLS
Journal: JAMA (1894)

SKIN. The skin, in ordinary cases, is dry and hot—often pungently so—until the exudative stage is completed, whereupon a gentle perspiration appears. When sweating occurs it is usually first noticeable upon the head and parts of the body which are warmly covered, and is most abundant at night. In weakly and anemic patients the perspiration usually comes on earlier than in others. The appearance of moderate sweating after the height of the fever has been attained is generally followed by considerable relief to some of the most distressing symptoms and is of good import. Sturges has never been able to satisfy himself that sweating was either of good or evil augury. Dietl was of the opinion that no relief was afforded by early perspiration or by those induced by sudoriflcs, but in this view I can not coincide. It is true that some of the most severe cases pass on
Viability index on electromechanical mapping can determine the extent of residual myocardial viability in patients with ischemic cardiomyopathy as defined by quantitative SPECT myocardial perfusion imaging Habib Samady, Yi-Hwa Liu, Michael Ragosta, Stephen Pfau, Michael Cleman, Eric R. Powers, C. Joon Choi, Jennifer Hunter, Frans J. Wackers, George A. Beller, Christopher M. Kramer, Denny Watson. University of Virginia, Charlottesville, VA, Yale University, New Haven, CT
Journal: Journal of the American College of Cardiology (2001)
Abstract 17336: Marked Improvement in BP Control Albeit With Recent Decline and Persistence of Racial Disparities in Veterans 2000 to 2014
Authors: Ross D Fletcher, Richard L Amdur, Raya Kheirbek, Vasilios Papademetiou, David D Maron, Charles Faselis, Ronald E Jones
Journal: Circulation (2015)

Background: The VA Electronic Health Record (VAEHR) contributes to effective management and control of hypertension and stores data longitudinally. We examined associations of BP control with age, race, ethnic group, and hypertensive drug treatment. Methods: In the VAEHR, vital signs were analyzed from 2000 through 2014 and medication records from 2004 to 2014. Patients with elevations &gt;140 systolic or &gt;90 diastolic on three separate days were considered hypertensive. Prescription coverage gaps due to late filling and renewals were examined to compute each patient’s % of days covered per month. Results: Of 8,813,000 patients followed in the VA system, 3,160,606 were hypertensive. In the total population BP control rates improved from 41.3% in 2000 to 74.6%.in 2010, but gradually declined to 71.3% by 2014. African Americans increased from 40.1% in 2000 to 70.8% in 2010 and declined to 67.4% in 2014 while Whites increased from 42.0% in 2000 to 75.7% in 2010 and fell to 72.4% in 2014. Hispanic control rates were initially 2% worse but are similar to Whites since 2004. While the increase was 5% better in Whites and Hispanics than in African Americans the decline in control rate of 3.3% (p&lt;.0001) starting in 2010 was similar in all racial and ethnic groups (fig.), and in all age groups. For ACEi, alpha blockers, beta blockers, and diuretics, the average coverage per month was 72% for Whites and 67% for African Americans. This 5% disparity did not change after 2010. These gaps can be reduced using “Park a Prescription” to maintain coverage while waiting for drug renewal. Conclusions: Data from VAEHR over a 14 year period shows a marked improvement over 30% for the first 10 years but a slow decline of 3.3% in the last 4 years. Eliminating drug gaps, which occur in all races, and improving treatment of hypertension should increase BP control rates to and above previous levels. Figure: Percent of hypertensive patients with controlled BP each month, stratified by race improving each summer.
Advice zone
Authors: Brian Angus, Simon Eccles, Annie Hastie, Simon Eccles, Philip Crockett, Alison Bigrigg
Journal: BMJ (2004)

Got a career or university related problem that needs answering? Can9t find the right person to point you in the right direction? Log on to the Advice Zone at www.bmjcareers.com/advicezone to post a question or to see if one of our experts has already solved your problem
Radiation Oncology
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Aqueous Extracts of Cigarette Tar Containing the Tar Free Radical Cause DNA Nicks in Mammalian Cells
Authors: Koni K. Stone, Eliezer Bermudez, William A. Pryor
Journal: Environmental Health Perspectives (1994)

The ability of aqueous extracts of cigarette tar to nick DNA was investigated using viable mammalian cells.Tar extracts contain a radical with a stable electron spin resonance (ESR) signal at g = 2.0036 characteristic of a semiquinone.The association of the tar component that carries the ESR signal with DNA was demonstrated using viable rat alveolar macrophages.The formation of single-strand DNA breaks caused by cigarette tar extracts in viable rat thymocytes follows saturation kinetics, indicating a tar component associates with DNA and then nicks it.These studies support our hypothesis that tar components that contain the cigarette tar radical can enter cells, associate with, and then nick DNA.-
Williams C. Cruikshank (1745-1800) surgeon of Leicester Square
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ACETYLSALICYLIC ACID, OR "WHAT'S IN A NAME?"
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Meet the First Authors
Authors: Suzanne Eken, Wojciech Wojakowski
Journal: Circulation Research (2017)

Her main interest is vascular surgery, and her PhD thesis revolves around cardiovascular non-coding RNA therapies.Performing vascular (micro)surgical techniques in animal models also helps her to acquire the dexterity needed for a future career in vascular surgery.As for all young scientists with families, combining this occupation with children is currently her major challenge-she managed to successfully revise this manuscript just 3 days before her youngest child was born!Intramyocardial CD133 + Cells in Refractory Angina (p 670)
STEM-30. NECROPTOTIC ASTROCYTES CONTRIBUTE TO MAINTAINING STEMNESS OF DISSEMINATED MEDULLOBLASTOMA THROUGH CCL2 SECRETION
Authors: Hailong Liu, Youliang Sun, Janusz Franco-Barraza, Z John Wang, Xinguang Yu, Shiyu Feng
Journal: Neuro-Oncology (2020)

Abstract Medulloblastoma (MB) with metastases at diagnosis and recurrence correlates with poor prognosis. Unfortunately, the molecular mechanism underlying metastases growth has received less attention than primary therapy-naïve MB. Though astrocytes have been frequently detected in brain tumors, their roles in regulating the stemness properties of MB stem-like cells (MBSCs) in disseminated lesions remain elusive. Effects of tumor-associated astrocytes (TAA)-secreted CCL2 on MBSCs self-renewal was determined by immunostaining analysis. Necroptosis of TAA was examined by measuring necrosome activity. Alterations in Notch signaling were examined after inhibition of CCL2. Progression of MBSCs-derived tumors was evaluated after pharmaceutical blockage of necroptosis. TAA, as the essential components of disseminated tumor, produced high level of CCL2 to shape inflammation microenvironment, which stimulated the enrichment of MBSCs in disseminated MB. In particular, CCL2 played a pivotal role in maintaining stem-like properties via JAK2/STAT3 mediated activation of Notch signaling. Loss of CCL2/CCR2 function repressed JAK2/STAT3-Notch pathway and impaired MBSCs proliferation, leading to a dramatic reduction of stemness, tumorigenicity and metastasizing capability. Furthermore, necroptosis-induced CCL2 release depended on RIP1/RIP3/MLKL activation in TAA, which promoted the oncogenic phenotype. Blockade of necroptosis resulted in CCL2 deprivation and compromised MBSCs self-proliferation, indicating MBSCs outsourced CCL2 from necroptotic TAA. Finally, CCL2 was upregulated in high-risk stages of MB, further supporting its value as a prognostic indicator. These findings highlighted the critical role of CCL2/CCR2 in Notch signaling activation in MBSCs, and revealed a necroptosis-associated glial cytokine microenvironment driving stemness maintenance in disseminations.