tbuckley/cabot-search huggingface dataset:
Barriers to communication in multidisciplinary breast cancer teams
Authors: F. M. Boyle, E. Robinson, P. Heinrich, S. M. Dunn
Journal: Journal of Clinical Oncology (2004)

6133 Background: Multidisciplinary teams have been recommended for patient care in breast cancer, with potential benefits including improvements in survival, quality of life and recruitment to clinical trials, and reductions in waiting times and service duplication. The literature highlights potential obstacles which may impede effective functioning of cancer teams, including inter-professional and interpersonal barriers and healthcare system characteristics. Methods: Members of multidisciplinary teams in 5 Australian states were surveyed, to assess the impact of potential barriers, including confidentiality; time pressures; individual responsibilities; "group think"; stress due to team membership; lack of support from other disciplines; uncertainty about responsibility for addressing psychosocial concerns; poor patient orientation; facilitation of meetings; inter-professional boundaries; facilities; administrative support; reimbursement; gender biases; hierarchies; terminology; delays due to interruptions; and disparate communication of prognosis. Results: 58 health professionals responded to the questionnaire. The most problematic issues for professionals in the Australian context were: Time pressures reducing the effectiveness of multidisciplinary meetings (65%); Insufficient administrative support (54%); Stress arising from teamwork (45%); Insufficient facilities for team meetings (43%); Lack of reimbursement for time spent in meetings (39%). Issues that were thought to be well-managed included: Patient confidentiality (78.9%); Gender biases not hindering effective communication (77%); Terminology across disciplines not posing a problem (74%); Individual responsibility for patient care not reduced through multidisciplinary teamwork (67%); Facilitation of meetings being appropriate (44%). Conclusions: The data highlights that health system barriers are generally perceived to be more important in hampering team performance than interpersonal or interprofessional issues, and will need to be addressed systematically to improve communication in Australian breast cancer teams. No significant financial relationships to disclose.
Arsenic Contamination
Authors: M. J. Friedrich
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Selected New Books
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Report of the Health Officer of the District of Columbia.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Phospholipase D2 Mediates Acute Aldosterone Secretion in Response to Angiotensin II in Adrenal Glomerulosa Cells
Authors: Haixia Qin, Michael A. Frohman, Wendy B. Bollag
Journal: Endocrine Reviews (2010)

In primary bovine adrenal glomerulosa cells, the signaling enzyme phospholipase D (PLD) is suggested to mediate priming, the enhancement of aldosterone secretion after pretreatment with and removal of angiotensin II (AngII), via the formation of persistently elevated diacylglycerol (DAG). To further explore PLD’s role in priming, glomerulosa cells were pretreated with an exogenous bacterial PLD. Using this approach, phosphatidic acid (PA) is generated on the outer, rather than the inner, leaflet of the plasma membrane. Although PA is not readily internalized, the PA is nonetheless rapidly hydrolyzed by cell-surface PA phosphatases to DAG, which efficiently flips to the inner leaflet and accesses the cell interior. Pretreatment with bacterial PLD resulted in priming upon subsequent AngII exposure, supporting a role of DAG in this process, because the increase in DAG persisted after exogenous PLD removal. To determine the PLD isoform mediating aldosterone secretion, and presumably priming, primary glomerulosa cells were infected with adenoviruses expressing GFP, PLD1, PLD2, or lipase-inactive mutants. Overexpressed PLD2 increased aldosterone secretion by approximately 3-fold over the GFPinfected control under basal conditions, with a significant enhancement to about 16-fold over the basal value upon AngII stimulation. PLD activity was also increased basally and upon stimulation with AngII. In contrast, PLD1 overexpression had little effect on aldosterone secretion, despite the fact that PLD activity was enhanced. In both cases, the lipase-inactive PLD mutants showed essentially no effect on PLD activity or aldosterone secretion. Our results suggest that PLD2 is the isoform that mediates aldosterone secretion and likely priming.
Drug Use in Anchorage, Alaska
Authors: Margaret R. Porter
Journal: JAMA (1973)

Of all public school students surveyed by a one-page questionnaire, 36.3% reported experimentation with a drug other than alcohol or tobacco, 19.8% reported use ten or more times, and 4.5% reported frequent current use. High figures for an elementary school population indicated that 14.6% of sixth graders had used a drug other than alcohol or tobacco. Alcohol, tobacco, marihuana, solvents, nonprescription stimulants, and hashish were the most commonly reported drugs for all students. Marihuana use was correlated with use of other drugs. Most drugs showed increased usage rates compared to previous investigations, with marked increases noted for hashish, mescaline, and propoxyphene hydrochloride. Usage rates were approximately equal for boys and girls, and increased as grade level increased. Racial differences in usage were noted.
Comparative analysis of myeloid-derived suppressor cell (MDSC) subsets in patients with gastrointestinal (GI) malignancies.
Authors: Austin G. Duffy, Fei Zhao, Suzanne Fioraventi, Tim Greten
Journal: Journal of Clinical Oncology (2012)

228 Background: Immune-based therapies have begun to demonstrate efficacy in GI oncology. However immune-suppressor mechanisms have been described which interfere with host anti-tumor immunity. Myeloid derived suppressor cells (MDSCs) constitute a heterogenous population known to be increased in patients with GI cancer. MDSCs inhibit the host anti-tumor immune response, limiting the effectiveness of both immune and non-immune treatments. Characterization of MDSCs in humans has been difficult with heterogeneous phenotype classification. Differences in processing are also potentially important. The aim of this study was to perform a comparative analysis of MDSC subsets in patients with GI cancer. Methods: Fluorescence activated cell sorting (FACS) analysis was performed on PBMC and whole blood (WB) lysates from both healthy adults and patients with advanced hepatocellular, colorectal and pancreatic cancer. Antibodies used for subtype characterization: anti-CD14, anti-CD15, anti-HLA-DR, anti-CD33, anti-CD11b. Functional studies performed to confirm MDSC status included thymidine proliferation assay on sorted cell populations. Results: Samples were obtained from 20 patients with advanced GI cancer and healthy volunteers and processed accordingly. Based on published data the following MDSC subtypes were analyzed: A) CD14 + , HLA-DR −/low ; B) CD15 + ,CD14 - CD33 + CD11b + .The frequency of each subset is shown in the table below. Functional studies will also be presented. Conclusions: Characterization of MDSCs in humans has been difficult with heterogeneous and often contradictory phenotype classification. In addition, there is considerable variability depending on which component of the blood is analyzed and how the sample is processed. This study confirms the increase in both MDSC populations in patients with GI cancer. [Table: see text]
Discussion Summary: Potential Hazards Related to Other Nonoccupational Exposures
Authors: * Moderators, Roger Cortesi, Herbert Needleman, John Rapporteurs, Gary Viren
Journal: Environmental Health Perspectives (1985)

commented on the possible influence of external factors such as in- fection on the induction of renal tumors in animals chronically exposed to gasoline.Although he agreed that many reviewers considered the tumor incidence to be strictly the result of gasoline exposure, he asked Dr. Enterline to comment on whether external factors might still be important.Dr. Enterline (University of Pittsburgh) indicated that the animal data he presented will be published soon.The authors view the results as a positive indication of renal tumor induction.To his knowledge infection was not a probable factor.There is little doubt that the data show a positive effect in the male rat.Dr. Enterline indicated that there is a greater uncertainty as to whether the rat is a good model for human cancer, and specifically kidney cancer.In response to another comment by Dr. Vostal, Dr. Enterline indicated that EPA thought the animal study furnished sufficient evidence of the carcinogenicity of unleaded gasoline vapors in rats and mice, for gasoline to be considered a potential human carcinogen.The ac- tual constituent of gasoline that might produce renal tumors is not known, but EPA suggests that benzene might be an active component.Dr. Enterline stated that he disagreed with the notion that benzene might be associated with kidney cancer.Occupational cohort studies of benzene-exposed workers have not shown excess kidney cancer, and more recent studies suggest that the active component of gasoline could be an iso- paraffin or isooctane rather than an aromatic constituent.Dr. McDonald (McGill University, Montreal) asked Dr. Enterline whether the effects seen in animals were specific to gasoline or could be expected with other sol- vents.Dr. Enterline said dry cleaning workers exposed to Stoddard solvent have shown a higher kidney cancer mortality than expected in some epidemiological stud- ies.Other dry cleaning agents could be involved here.He pointed out the need to identify other exposed pop- ulations to address the question raised by Dr. Mc-
Duplicate publication
Authors: Mathew E. Brunson, Gary L. Davis, Johnson Y.N. Lau, Juan C. Scornik, Richard C. Howard, William W. Pfaff
Journal: Hepatology (1994)

We are writing in response to your letters of March 17 and March 9, 1994, which point out the existence of overlaps in content in the articles published in HEPA-TOLOGY (1) and Transplantation (2).The letters prompted us, as authors and coauthors, to compare the published versions of both manuscripts, and we concluded that indeed there are areas of duplication in the papers.Although this was not our intent, we recognize that such duplication is inappropriate and against the publication guidelines of both journals.The virological analysis of serum samples formed the basis of a focused report that was presented by Lau et al.in HEPATOLOGY.As the analysis evolved, it was evident that valuable clinical information that was not included in the initial manuscript deserved further publication.Thus the Transplantation paper was conceived as a follow-up of the HEPATOLOGY paper; we feel it presented valuable new clinical data.However, we now recognize that the message of the follow-up paper was not clearly delineated from the first one.We regret that the Transplantation paper, by detailing the method of viral analysis and restating virological results, gave the mistaken impression that these were new data.The presentation of these viral data was meant only
A Method of Record Linkage
Authors: Akira Oshima, Fumio Sakagami, Aya Hanai, Isaburo Fujimoto
Journal: Environmental Health Perspectives (1979)

In cancer epidemiology, prospective approaches are very important both in testing etiological hypotheses and in evaluating preventive procedures. Prospective studies, however, are very difficult and expensive, because a large number of people and a long period of observation are necessary for a satisfactory study. As a data source for follow-up studies, population-based cancer registry is very useful. The Osaka Cancer Registry has been in operation since December, 1962. Since 1968 the data processing, including the work of collation, has been semicomputerized. In order to identify cancer patients, we use the following six indices: date of birth, first Chinese character of a person's family name, address a: city, ward, town or village, address b: further details. i.e., street, avenue, section, hamlet etc., site, and sex. When we have data on the collation indices for the subjects to be followed up, we can conduct follow-up studies easily and accurately, using a semicomputerized collation method similar to that in the cancer registration system. Because the master file of the Osaka Cancer Registry contains the data of cancer cases reported and all cancer deaths among the residents of Osaka Prefecture, we can follow up the subjects living in Osaka Prefecture and obtain data about vitually all cancer incidences and deaths among them. In this follow-up method by means of record linkage to the cancer registry, some considerations should be taken into account for the following factors; coverage of cancer data in the Osaka Cancer Registry, reliability of the collation method, and address of the subjects to be followed up. As an example of a study with this method, we present the follow-up study of the screenees of a mass screening program for stomach cancer.
The Achilles Reflex, A Diagnostic Test of Thyroid Dysfunction
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SALVAGE OF THE JEOPARDIZED MYOCARDIUM IN EVOLVING MYOCARDIAL INFARCTION BY INTRAVENOUS STREPTOKINASE THERAPY: ASSESSMENT BY QUANTITATIVE Tl-201 IMAGING.
Authors: Jamshid Maddahi, Abraham T. Weiss, James Kropac, Ivor Geft, PK Shah, Daniel S. Berman, Alan Waxman, H JC Swan, William Ganz
Journal: Clinical Nuclear Medicine (1983)

Maddahi, Jamshid; Weiss, Abraham T.; Kropac, James; Geft, Ivor; Shah, PK; Berman, Daniel S.; Waxman, Alan; Swan, H JC; Ganz, William Author Information
Incidence of End-Stage Renal Disease Among Persons With Diabetes—United States, 1990-2002
Journal: JAMA (2005)

Diabetes mellitus is the leading cause of end-stage renal disease (ESRD) (i.e., kidney failure requiring dialysis or transplantation) in the United States, accounting for 44% of new cases of treated ESRD in 2002. To examine trends in ESRD attributed to diabetes mellitus (ESRD-DM) in the United States, CDC analyzed 1990-2002 data from the United States Renal Data System (USRDS) and the National Health Interview Survey (NHIS). This report summarizes the findings of that analysis, which indicated that, although the number of new cases of ESRD-DM increased overall, the incidence of ESRD-DM among persons with diabetes is not increasing among blacks, Hispanics, men, and persons aged 65-74 years, and is declining among persons aged <65 years, women, and whites. Continued interventions to reduce the prevalence of risk factors for kidney disease and improve diabetes care are needed to sustain and improve these trends.
Is the Physician an “Easy Mark”?
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Regulation of tissue inhibitor of metalloproteinases-1 gene expression by cytokines and dexamethasone in rat hepatocyte primary cultures
Authors: E Roeb
Journal: Hepatology (1993)

The steady-state levels of extracellular matrix proteins are regulated by the rates of their synthesis and degradation. Metalloproteinases and their specific inhibitors, tissue inhibitor of metalloproteinases-1 and -2 are believed to play a crucial role in extracellular matrix protein degradation. Here we show that the tissue inhibitor of metalloproteinases-1 is expressed in rat hepatocytes in primary culture and regulated by inflammatory cytokines. Rat hepatocytes constitutively express mRNA of tissue inhibitors of metalloproteinases-1 at a low level. Incubation with conditioned medium from lipopolysaccharide-stimulated human monocytes led to a dramatic induction of mRNA of tissue inhibitors of metalloproteinases-1. The inflammatory cytokines interleukin-1β, interleukin-6, interleukin-11, leukemia inhibitory factor and ciliary neurotrophic factor were also capable of stimulating expression of mRNA of tissue inhibitors of metalloproteinases-1. Among these cytokines interleukin-6 was the most potent stimulator. The combination of interleukin-1β, interleukin-6 and interleukin-11 synergistically up-regulated mRNA of tissue inhibitors of metalloproteinases-1. The synthetic glucocorticoid dexamethasone dose dependently inhibited constitutive and interleukin-6-induced expression of tissue inhibitors of metalloproteinases-1. A possible involvement of tissue inhibitor of metalloproteinases-1 in the pathogenesis of liver fibrosis and cirrhosis is discussed. (HEPATOLOGY 1993;18:1437–1442.)
The Emerging Role of Benefit-Cost Analysis in the Regulatory Process at EPA
Authors: Ralph A. Luken
Journal: Environmental Health Perspectives (1985)

Almost since its inception, the U.S. Environmental Protection Agency (EPA) has been using analytical techniques related to the concept of balancing benefits and costs. As a result of the Reagan Administration's Executive Order 12291, benefit-cost analysis is playing an increasingly important role in the EPA regulatory process. Benefit-cost analysis has assisted in organizing information and improving cost estimates. It has influenced the choice of regulatory criteria and aided in the developing degrees of stringency for environmental regulations. The usage of benefit-cost analysis is limited by interpretations of portions of the Clean Air Act and Clean Water Act that restrict consideration of costs or establish technology standards. Benefit analysis is only as reliable as the underlying scientific data in the health effects area. Work by epidemiologists on the relationships between pollutant exposures and adverse health effects will play a vital role in EPA's ability to value in dollars the health improvements attributable to pollution control. EPA's Office of Policy, Planning and Evaluation is currently conducting combined economic and epidemiology research to develop methods and estimates of the health benefits of pollution control.