ANDROGEN THERAPY
Authors: W O THOMPSON
Journal: Annals of Internal Medicine (1949)

Article1 January 1949ANDROGEN THERAPYW. O. THOMPSON, M.D., F.A.C.P.W. O. THOMPSON, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-30-1-55 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONMany substances with androgenic properties have been isolated from the testes, adrenals, blood, and urine, but the most potent androgenic material isolated so far is testosterone. This substance was isolated from the testis by Laqueur and his colleagues in 19351 and was synthesized in the same year by Ruzicka2 and Butenandt.3 Various observations suggest that it is more potent when administered in the form of an ester than when given in the free form. In clinical medicine it is usually administered in the form of the propionate.Although other androgens have been isolated and prepared synthetically, they are rarely...Bibliography1. LAQUEURDAVIDDINGEMANSEFREUD EKEJ: Ueber Männliches Hormon: Unterschied von Androsteron aus Harn und Testosteron aus Testis, Acta brev. Neerland, 1935, v, 84. Google Scholar2. RUZICKAWETTSTEINKÄGI LAH: Sexual Hormone: VIII. Darstellung von Testosteron unter Anwendung gemischter Ester, Helvet chim. Acta, 1935, xviii, 1478. CrossrefGoogle Scholar3. BUTENANDTHANISCH AG: Ueber Testosteron: Umwandlung des Dehydroandrosterons in Androstendiol und Testosteron; ein Weg zur Darstellung des Testosterons aus Cholesterin, Ztschr. f. physiol. Chem., 1935, ccxxxvii, 89. CrossrefGoogle Scholar4. HUGGINS C: Prostatic cancer treated by orchiectomy: five year results, Jr. Am. Med. Assoc., 1946, cxxxi, 576. CrossrefGoogle Scholar5. THOMPSONHECKEL WONJ: Male sex hormone, clinical application, Jr. Am. Med. Assoc., 1939, cxiii, 2124. Google Scholar6. THOMPSON WO: Uses and abuses of the male sex hormone, Jr. Am. Med. Assoc., 1946, cxxxii, 185. CrossrefGoogle Scholar7. MOORE CR: Physiology of the testis, in Glandular Physiology and Therapy, 1942, American Medical Association, Chicago. Google Scholar8. TÖRNBLOM N: Internal secretion of the germinal tissue of the testes and prostatic hypertrophy, Upsala läkaref. förh., 1942, xlviii, 1. Google Scholar9. MCCULLAGH DR: Dual endocrine activity of the testes, Science, 1932, lxxvi, 19. CrossrefGoogle Scholar10. THOMPSONHECKEL WONJ: Undescended testes. Present status of glandular treatment, Jr. Am. Med. Assoc., 1939, cxii, 397. CrossrefGoogle Scholar11. HUGGINS C: Endocrine control of prostatic cancer, Science, 1943, xcvii, 541. CrossrefGoogle Scholar12. HERRMANNADAIR JBFE: Effect of testosterone propionate on carcinoma of female breast with soft tissue metastases, Jr. Clin. Endocrinol., 1946, vi, 769. CrossrefGoogle Scholar13. SCHWANDERMARVIN HHN: Treatment of carcinoma of human breast with testosterone propionate: report of five cases, Jr. Clin. Endocrinol., 1947, vii, 423. CrossrefGoogle Scholar14. Report of a Subcommittee of the Therapeutic Trials Committee of the Council on Pharmacology and Chemistry of the A.M.A.: Estrogens and androgens in mammary cancer, Jr. Am. Med. Assoc., 1947, cxxxv, 987. Google Scholar15. SNAPPER I: Castration combined with testosterone treatment after mastectomy for breast cancer: endocrinologic and metabolic changes, Jr. Mt. Sinai Hosp., 1947, xiv, 618. Google Scholar16. AYRE JE: Cervical cancer: disordered growth response to inflammation in presence of estrogen excess and nutritional deficiency, Am. Jr. Obst. and Gynec., 1947, liv, 363. CrossrefGoogle Scholar17. LESSER MA: Testosterone and propionate therapy in 100 cases of angina pectoris, Jr. Clin. Endocrinol., 1946, vi, 549. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, Illinois*Read at the Twenty-Ninth Annual Session of the American College of Physicians, San Francisco, California, April 21, 1948.From the Department of Medicine, University of Illinois College of Medicine and the Grant and Henrotin Hospitals, Chicago. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDie SexualhormoneThyreostatikaThyreostatikaCLINICAL RECOGNITION AND TREATMENT OF ACUTE POTASSIUM INTOXICATION*JOHN P. MERRILL, M.D., HAROLD D. LEVINE, M.D., F.A.C.P., WALTER SOMERVILLE, M.D., M.R.C.P., STEPHEN SMITH 3rd, M.D. 1 January 1949Volume 30, Issue 1Page: 55-68KeywordsAndrogensBloodHospital medicinePropionatesTestesTestosteroneUrine ePublished: 1 December 2008 Issue Published: 1 January 1949 PDF downloadLoading ...