tbuckley/cabot-search huggingface dataset:
Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L
Authors: Kohichi Matsunaga, Eiji Morita, Tatsuya Saitoh, Shizuo Akira, Nicholas T. Ktistakis, Tetsuro Izumi, Takeshi Noda, Tamotsu Yoshimori
Journal: The Journal of Experimental Medicine (2010)
<i>Circulation:</i> Clinical Summaries
Journal: Circulation (2012)

Survival After Alcohol Septal Ablation for Obstructive Hypertrophic CardiomyopathyThe clinical efficacy of alcohol septal ablation for obstructive hypertrophic cardiomyopathy has been demonstrated, but the effects of the procedure on late survival remain uncertain.We examined 177 patients (mean age, 64 years; 68% women) who underwent septal ablation at our institution.The survival of patients who had septal ablation was no different than the expected survival for a comparable general population (8-year estimate, 79%), and similar to that of age-and sex-matched patients who underwent isolated surgical myectomy.The annual incidence of sudden cardiac death was Ϸ1.3%.This study demonstrates that favorable long-term survival can be achieved in carefully selected patients who undergo septal ablation by experienced operators in a tertiary referral hypertrophic cardiomyopathy center.See p 2374.
From the Congressional Office of Technology Assessment
Authors: T. Mark
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
J Neuropathology &amp;amp; Exp Neurology, Baltimore
Journal: JAMA (1966)

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DS28: Floater or heartsink? Recognizing tissue artefact in Mohs micrographic surgery
Journal: British Journal of Dermatology (2021)

were offered SIWH rather than flap or graft repair.Although the majority were satisfied with their outcome, they reported prolonged healing times, and many were not offered alternative wound closure.We now plan to improve our consent process to offer patients a range of repair options for their lower leg surgery.We suspect thatalthough this study was not powered to detect itflaps and grafts are likely to lead to shorter healing times overall, with an associated reduction in burden on community nursing teams.This work adds to the body of evidence that lower leg surgery is associated with prolonged healing and a high complication rate.This needs to be included in the consent conversation. DS28Floater or heartsink?Recognizing tissue artefact in Mohs micrographic surgery
AMA Insights
Journal: JAMA (1984)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
New Names
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Re-epithelialisation of Barrett's oesophagus
Authors: C KELTY
Journal: Gut (2000)

Editor,—We were interested to read the case report by Van Laethem and colleagues of a carcinoma arising under a re-epithelialised segment of Barrett's oesophagus ((2000) Gut 46:574–574; [OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4]) . This raises issues in … [1]: {openurl}?query=rft.jtitle%253DThe%2BAmerican%2Bjournal%2Bof%2Bgastroenterology%26rft.stitle%253DAm%2BJ%2BGastroenterol%26rft.aulast%253DByrne%26rft.auinit1%253DJ.%2BP.%26rft.volume%253D93%26rft.issue%253D10%26rft.spage%253D1810%26rft.epage%253D1815%26rft.atitle%253DRestoration%2Bof%2Bthe%2Bnormal%2Bsquamous%2Blining%2Bin%2BBarrett%2527s%2Besophagus%2Bby%2Bargon%2Bbeam%2Bplasma%2Bcoagulation.%26rft_id%253Dinfo%253Adoi%252F10.1111%252Fj.1572-0241.1998.525_b.x%26rft_id%253Dinfo%253Apmid%252F9772036%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1111/j.1572-0241.1998.525_b.x&link_type=DOI [3]: /lookup/external-ref?access_num=9772036&link_type=MED&atom=%2Fgutjnl%2F47%2F5%2F741.1.atom [4]: /lookup/external-ref?access_num=000076315900005&link_type=ISI
Infantile Colic
Authors: William M. Liebman
Journal: JAMA (1981)

Intolerance to lactose and cow's milk protein was prospectively evaluated in 56 infants with apparent colic. A complete blood cell count, sedimentation rate, test for quantitative IgE level, radioallergosorbent test (performed in 15 patients), and at least three stool examinations for pH, presence of reducing substances, and occult blood were performed in 56 infants (46, appropriate size for gestational age; ten, small for gestational age) and results were within normal limits for age. This study suggests that tolerance to lactose and cow's milk protein does not have a significant role in infantile colic. (<i>JAMA</i>1981;245:732-733)
BELGIUM
Journal: JAMA (1953)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Thyroid Hormone Use and Bone Mineral Density-Reply
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
人皮肤表皮中黑色素分布依据
Authors: N. Joly-Tonetti, J.I.D. Wibawa, M. Bell, D.J. Tobin
Journal: British Journal of Dermatology (2018)

皮肤由三个主要分层组成, 最外层为表皮。表皮本身由另外 4 层组成: 最下方为基底细胞层, 在这里, 被称为黑素细胞的皮肤细胞持续生成皮肤色素 (黑色素) 。表皮中 90% 细胞为角质细胞, 这些细胞会繁殖并从基底细胞层向上迁移到皮肤表面, 黑色素就是由这些角质细胞携带。科学家们调查了皮肤黑色素总量, 发现大部分黑色素停留在基底细胞层, 只有少部分上移到皮肤表面, 但原因尚不清楚。曾经认为随着角质细胞离开基底层向上移动, 黑色素可能降解。这项来自英国的研究挑战了这一观点。这些研究者们对 11 名高加索裔女性的皮肤进行了检测, 重点关注分裂的角质细胞 (形成两个新细胞) 中的黑色素发生了什么。新细胞中的一个留在基底细胞层, 而另一个则向上移动。他们发现, 大部分黑色素处于留在基底层的细胞内, 而相比之下, 第二个注定离开基底层的细胞只有很少的黑色素。研究者们还发现, 这一分布在皮肤组织应激 (如组织再生或伤口愈合) 时可以反转, 此时两个新的细胞获得相同数量的黑色素。这项研究提供了重要信息, 有助于对皮肤色素性疾病进行进一步的研究。 Linked Article:Joly‐Tonetti et al. Br J Dermatol 2018; 179:1115–1126
"PROPHYLAXIS OF SYPHILIS WITH ARSPHENAMIN"
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sickling Tests
Authors: Rose G. Schneider
Journal: JAMA (1967)

Testing for erythrocyte sickling is a common procedure in many laboratories, and it is generally considered simple to perform and interpret. Nevertheless, we frequently receive reports which are found to be falsely positive or falsely negative, and such incorrect data have even been recorded in connection with investigations on the abnormal hemoglobins.<sup>1</sup>Recent discoveries of the existence of several dozen hereditary hemoglobin variants and the development of methods for their identification have made possible the recognition of many previously unknown hemoglobinopathies. Although such recognition depends largely on electrophoretic and genetic data, sickling tests often provide a valuable rapid diagnostic aid. The purpose of this paper is to describe conditions under which the reliability of these tests is frequently impaired. <h3>Precautions for Accuracy.—</h3> Obviously, the blood sample for testing must be the patient's own, unmixed with that of a donor. Yet, we receive a surprising number of samples which were
Fluorodensimetry
Authors: Ronald B. George
Journal: JAMA (1971)

Fluorodensimetry is a method for amplifying and recording changes in density which occur over the thorax during fluoroscopy, and thereby analyzing regional ventilation and diaphragm movement. This method was used to evaluate 13 normal subjects and over 300 patients with various ventilatory disturbances. Patients with chronic obstructive pulmonary disease (COPD) tended to shift ventilation toward upper lung zones, and diaphragm function was markedly altered in the presence of air trapping. Obese individuals without complicating COPD were able to increase diaphragm movement during voluntary deep breathing and thus shift ventilation toward the lower zones; obese patients with COPD did not. Localized air trapping in poorly communicating bullae or distal to obstructed major bronchi resulted in characteristic changes of regional ventilation.
Topical use of hydroquinone as a depigmenting agent
Authors: K. A. Arndt
Journal: JAMA (1965)

Hydroquinone is known to inhibit melanogenesis both in vitro and in vivo. In this study, 2% and 5% hydroquinone creams were topically applied to the hyperpigmented skin of 56 patients. Used in this way, hydroquinone was a moderately effective depigmenting agent in 80% of cases. The 2% cream appeared to be as effective therapeutically as the 5% cream and to evoke untoward side effects (primary irritation) much less often. Therapy with topically applied hydroquinone did not lead to complete disappearance of pathological hypermelanosis, but results were satisfactory enough to help most patients become less self-conscious about their pigmentary abnormalities.
The Rational Clinical Examination-Reply
Authors: John W. Williams
Journal: JAMA (1992)

<h3>In Reply.</h3> —Dr Lamb shares our enthusiasm for physical diagnosis and offers comments about other potentially useful signs for diagnosing ascites. He observes that an everted umbilicus is almost always due to ascites and advocates "Myers maneuver" for detecting a fluid wave, suggesting that it is easier to perform and as accurate as the traditional method for eliciting a fluid wave. For detecting small amounts of fluid, he suggests we use a "percussion variant" of the puddle sign. We suspect that other readers have favorite physical examination techniques that they believe useful for detecting ascites. Indeed, these techniques may improve on our existing repertoire of physical diagnosis maneuvers. However, we found no data on these tests in the literature, and unless Lamb has found something we missed, their accuracy is unknown. To separate the wheat from the chaff, we must rigorously test these findings so that the clinician will know
Expression of cathepsin D and B in invasion and metastasis of squamous cell carcinoma
Authors: A. KAWADA, K. HARA, E. KOMINAMI, M. HIRUMA, M. AKIYAMA, A. ISHIBASHI, H. ABE, E. ICHIKAWA, Y. NAKAMURA, S. WATANABE, T. YAMAMOTO, T. UMEDA, K. NISHIOKA
Journal: British Journal of Dermatology (1997)
Lettsomian Lectures on the Influence of Climate in the Treatment of Pulmonary Consumption
Authors: C. T. Williams
Journal: BMJ (1876)

PRESIDENT AND GENTLEMEN,-I would now draw your atten- tion to the isothermal lines of Great Britain and Ireland, not only as regards the climates of the whole, but as affecting particular portions of these islands in different months; for the monthly isothermal lines drawn by Mr. Alexander Buchan show very important facts, and I have attempted in this mapto give some of their results.The continuous black lines indicate the isothermalsofJanuary; the dotted lines those of August.It appears that, in winter, the isothermals, instead of following theTines of latitude, pursue an exactly opposite course, and during the months of December and January are almost vertical; thus the warm places are on the west and south coast in winter, and the cold ones on the east coast.The isotherm of 43 deg.Fahr.runs through the extreme south- west of Ireland, through Devonshire and the Channel Islands: the line of 39 deg.Fahr.passes through the Shetlands, along the islands off the west coast of Scotland to Hastings; and that of 40 deg.Fahr.through the Isle of Man, Llandudno, and Portsmouth.we see, too, that the British Channel varies greatly in its winter climates, and, as we advance from the Land's End and approach the Straits of Dover, the winter temperature gradually falls.In the month of January, in the Scilly Islands, it is 46 deg.Fahr.;
Pediatrics, Evanston, Ill
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
IgG4 and IgE are the major immunoglobulins targeting the NC 16A domain of BP 180 in bullous pemphigoid: Serum levels of these immunoglobulins reflect disease activity
Authors: Rebekka Döpp, Enno Schmidt, Iakov Chimanovitch, Martin Leverkus, Eva-B. Bröcker, Detlef Zillikens
Journal: Journal of the American Academy of Dermatology (2000)
Vitamin E in treatment of Huntington's chorea.
Authors: A Caro, S Caro
Journal: BMJ (1978)

with angina pectoris, especially for patients unable to tolerate beta-blockers.Even if the occasional patient does develop side effects such as those described, the fact that these are easily recognised and, in our experience to date, have always been reversible should provide reassurance to those who have doubts about prescribing this drug because of the development of neuropathy.
Breathholding spells in children. Differentiation from epileptic attacks
Authors: S. Livingston
Journal: JAMA (1970)

Severe breathholding spells in children follow a more or less constant clinical pattern, and the electroencephalogram is almost always normal. The spells generally appear during the first two years of life, but rarely before 6 months of age. They usually disappear spontaneously after 4 years of age and rarely recur after age 6 years. Breathholding episodes are observed almost exclusively in children with normal intelligence and do not cause demonstrable evidence of brain damage. However, they are frequently associated with or followed by behavioral disturbances. The familial incidence is high. Breathholding attacks are essentially innocuous and the general outlook is excellent. The associated unconsciousness and convulsions are very short and benign, and require no immediate care. The administration of antiepileptic or tranquilizing drugs or both is of no value. Treatment consists primarily of parent-child guidance and reassurance.
Expression of myelomonocytic antigens is associated with unfavourable clinicoprognostic factors in B-cell chronic lymphocytic leukaemia
Authors: A. Pinto, L. Del Vecchio, A. Carbone, M. Roncadin, R. Volpe, D. Serraino, S. Monfardini, A. Colombatti, V. Zagonel
Journal: Annals of Oncology (1991)
Drug interactions with anticoagulants
Authors: L. T. Sigell
Journal: JAMA (1970)

Combined or multiple drug therapy has become an accepted fact in medical practice. A study of<i>hospitalized</i>patients at the Johns Hopkins Hospital revealed that these patients received an average of 13 different drugs during their hospital stay.<sup>1</sup>The Division of Clinical Pharmacology at the University of Cincinnati surveyed prescriptions for 821<i>outpatients</i>of the Cincinnati General Hospital medical clinics. Although 15% of these patients were not treated with drugs, a few patients received as many as eight drugs at one time. The average was two drugs per patient. In a study from Florida, ambulant patients admitted taking an average of 3.5 different drugs (including over-the-counter drugs) during the two months<i>prior</i>to their outpatient clinic visit. Only 9% of these patients denied taking any drugs.<sup>2</sup>The incidence of adverse drug reactions has been shown to increase as the number of drugs taken concurrently increases.<sup>3</sup>Therefore, it