tbuckley/cabot-search huggingface dataset:
Comparison of abiraterone acetate (Abi) versus ketoconazole (Keto) in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC) refractory to docetaxel (D).
Authors: Avivit Peer, Maya Ish-Shalom, Natalie Maimon, Maya Gottfried, Ben Boursi, Raya Leibowitz-Amit, Raanan Berger, Avivit Neumann, Svetlana Kovel, Avishay Sella, Roberto Pili, Hans J. Hammers, Victoria J. Sinibaldi, Michael Anthony Carducci, Mario A. Eisenberger, Daniel Keizman
Journal: Journal of Clinical Oncology (2013)

146 Background: Abi is a standard treatment (tx) in pts with mCRPC refractory to deocetaxel. It is a potent and selective CYP 17 inhibitor that blocks the synthesis of androgens in the testis, adrenal glands, and prostate. However, in many countries where abi has not been approved yet, keto is used as an alternative CYP 17 inhibitor. Although preclinical data suggests that keto is a less specific and potent inhibitor of CYP 17, there are limited clinical data comparing both agents. We aimed to compare the clinical effectiveness of abi vs keto in pts with mCRPC refractory to D. Methods: Records from 156 mCRPC pts treated with keto 200 - 400 mg 3x day, in 4 centers across the US and Israel, were reviewed retrospectively. 26 pts treated post D were individually matched by clinicopathologic factors to pts treated with abi (selected from a multicenter Israeli database, n=120). We compared the PSA response (decrease ≥50% from baseline), biochemical and radiological progression free survival, and overall survival between the groups. Progression free survival and overall survival were determined by Cox regression. Results: The groups were matched by Gleason score, pre-tx disease extent (limited-axial skeleton and/or nodal vs extensive- appendicular skeleton and/or visceral), ECOG PS, pre-tx risk category (favorable, intermediate, poor; Keizman, Oncologist 2012). Furthermore, they were balanced regarding median age (71 abi vs 69 keto), time from primary tx to disease relapse, time to progression on prior GnRH-a and antiandrogen, PSA response and time to progression on prior D, pre-tx pain score/alkaline phosphatase/hemoglobin/ neutrophil to lymphocyte ratio/PSADT/PSA. In the groups of abi vs keto, PSA response was 46% vs 19% (OR 4.4, p=0.043), median biochemical PFS 7 vs 2 months (HR 0.65, p=0.02), median radiological PFS 6 vs 2.5 months (HR 0.63, p=0.016), median overall survival 17 vs 12 months (HR 0.53, p=0.79), and tx interruption d/t adverse events 12% vs 23% (0R 0.6, p=0.023). Conclusions: In mCRPC refractory to D, the outcome of pts treated with abiraterone was superior to ketoconazole.
INTERNATIONAL ABSTRACTS
Journal: JAMA (1985)

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Estimating Exposure to Environmental Tobacco Smoke
Authors: Christopher R. E. Coggins
Journal: JAMA (1996)

<h3>To the Editor.</h3> —Dr Pirkle and colleagues<sup>1</sup>suggest that further research is needed to determine the health relevance of ETS exposures that result in serum cotinine concentrations of approximately 1 ng/mL. However, Pirkle et al fail to discuss that we reported data<sup>2-4</sup>that show animals exposed to smoke repeatedly for 6 hours per day, with resultant mean cotinine concentrations at the end of the exposures up to 165 ng/mL, had effectively no toxicologic changes. Importantly, the particulate concentrations we used (up to 10 mg/m<sup>3</sup>) were large exaggerations of ETS concentrations (approximately 30 μ/m<sup>3</sup>) that have been reported in areas where smoking is allowed.<sup>5</sup>
Appendix: Methodology
Authors: Max H. Myers
Journal: JNCI Journal of the National Cancer Institute (1967)

Journal Article Appendix: Methodology Get access Max H. Myers Max H. Myers Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 39, Issue 2, August 1967, Pages 204–207, https://doi.org/10.1093/jnci/39.2.204 Published: 01 August 1967
On the Medical Services of the Navy and Army from the Accession of Henry VIII to the Restoration
Authors: W. R. E. Smart
Journal: BMJ (1874)

99lost his speech and his sight became dim; he retained consciousness sufficiently to enable him to make signs to his fellow workmen to catch him; the unconsciousness became complete, and he was con- vulsed, the entire attack lasting about ten minutes.Other symptoms were frequent giddiness, causing him occasionally to fall, starting in his sleep; at times, perspirations, or a feeling of stiffness in the tongue.Iodide of potassium was given, at first, in doses of six grains, gradually raised to twenty grains.He only had one complete seizure, and the giddiness became less and less frequent and severe.CASE VIII.Syphilitic Eruptionz; E-pileptVform Attack.-RoseR., aged 24, had been in the Lock Hospital three years before for syphilis.For four months, she had been subject to an eruption on the scalp, and, when this was absent, she suffered from pain in the head and fits of epileptiform character, with loss of consciousness and struggles.These last came on very irregularly, sometimes three or four in a day ; at others, two or three in the course of a week ; and, at another time, they might be absent for a week.She had a papular eruption along the roots of the hair, and crusts on the back of the head.The erup- tion soon disappeared, and the fits ceased, under the administration of five-grain doses of the iodide of potassium.Looking over my notes of old cases of epilepsy, I find several which, in the light of subsequent experience, I am now inclined to set down as of syphilitic origin, notwithstanding the absence of ascertainable syphilitic antecedents.I may now sum up the features of epilepsy, symptomatic of syphilitic disease of the brain, by which it may be distinguished from ordinary epilepsy.As to the convulsive attacks themselves, there is nothing distinctive either in their character or frequency, or in the time of their access, i.e., whether nocturnal or diurnal.It is difficult to obtain a reliable description of a convulsive seizure, and the opportunities of watching an attack are very rare; but, after careful questioning of witnesses in cases of idiopathic and syphilitic epilepsy, I have come to the conclusion given, which is, moreover, that generally accepted.If this statement can be qualified in any way, it would be by thei greater irregularitv of the intervals between the fits.An important distinction, however, exists in the fact, that the in- tervals between the convulsive paroxysms, due to syphilitic disease of the brain, are not intervals of perfect health and freedom from nervous disorders.On the contrary, if there are not nocturnal head- aches, or osteocopic pains, or sleeplessness, such as are caused by syphilis, independently of disease of the brain and diagnostic of syphilis, there may be frequent attacks of petit mal, often many times a day, or of convulsive twitchings of the eyes or of a limb, or merely of vertigo or of faintness ; or there may be a state of extreme and unaccountable nervousness and apprehension.
Management of hepatitis C in primary healthcare in the country of Georgia
Authors: Tengiz Tsertsvadze, Akaki Abutidze, Lali Sharvadze, Nikoloz Chkhartishvili, Amiran Gamkrelidze, Lia Gvinjilia, Maia Butsashvili, David Metreveli, Vakhtang Kerashvili, Shaun Shadaker, Muazzam Nasrullah, Tamar Gabunia, Ekaterine Adamia, Stefan Zeuzem, Nezam Afdhal, Sanjeev Arora, Karla Thornton, Francisco Averhoff
Journal: Journal of Hepatology (2020)
FURTHER OBSERVATIONS IN REGARD TO RADIUM.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Distribution of Organs for Liver Transplantation
Authors: R. Patrick Wood
Journal: JAMA (1994)

<h3>To the Editor.</h3> —I was disturbed by the article by Dr Bronsther and colleagues<sup>1</sup>regarding the prioritization of livers for transplantation. Rather than manufacture a rationale to justify their claim to a greater share of the limited pool of donor livers, the authors would better serve the transplant community by addressing the donor shortage. Alexander and Vaughn<sup>2</sup>showed that 25% of the patients awaiting transplantation died because of the lack of a donor liver. Any discussion of liver distribution must be tempered by the fact that there are too few livers available for all potential recipients, and even if all transplants were carried out at one center, there would still be a substantial mortality rate for patients on the waiting list. As long as the number of potential recipients exceeds the supply of donor livers, any revision of the present allocation system would accomplish nothing more than changing
Chest Medicine
Authors: David W. Cugell
Journal: JAMA (1983)

As noted by the authors in their preface, there is no dearth of "excellent textbooks of pulmonology and pulmonary physiology currently available." Their objectives in presenting this text are to "emphasize clinically relevant new material." This they have largely achieved, but some recent developments, eg, use of the single-breath carbon monoxide diffusing capacity as a diagnostic aid in patients with intrapulmonary bleeding, receive scant attention—a problem that is inevitable in any textbook that covers a dynamic medical subspecialty. This text is organized in a conventional manner. The first third is devoted to lung structure and function, plus the clinical and diagnostic procedures appropriate to this specialty. The balance of the text, "Clinical Patterns of Lung Disease," contains 11 chapters. There is the usual mixture of chapters that review disease by anatomical region (eg, disease of the pleura), and by cause (eg, respiratory infection). Approximately 90 pages are devoted to an
THE COST OF ANTIVACCINATION.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Punch Drunk
Authors: Hugh H. Hussey
Journal: JAMA (1976)

Browsing in Mencken's<i>The American Language</i>is more likely than not to be rewarding. For example, in the chapter on slang, Mencken lists terms that originated among prizefighters and their attendants.<sup>1</sup>For one of the words, he cited a reference toThe Journalwherein "punch drunk" achieved acceptance into medical terminology. So it was that Martland<sup>2</sup>wrote, in part, as follows: For some time fight fans and promoters have recognized a peculiar condition occurring among prize fighters which, in ring parlance, they speak of as "punch drunk." Fighters in whom the early symptoms are well recognized are said by the fans to be "cuckoo," "goofy," "cutting paper dolls," or "slug nutty".... The early symptoms of punch drunk usually appear in the extremities. There may be only an occasional and very slight flopping of one foot or leg in walking, noticeable only at intervals; or a slight unsteadiness in
Comparison of Corticosteroid and Sulphasalazine (Salicylazopyridine) Therapy in Ulcerative Colitis
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Leads from the MMWR. Diphtheria, tetanus, and pertussis: guidelines for vaccine prophylaxis and other preventive measures
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
L'exploration fonctionnelle de la rate: Diagnostic et traitement des syndromes spléniques
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Therapeutics
Authors: A. Azimi, S. Kuznecovs, J. Kuznecovs, A. Blazejczyk, M. Switalska, S. Chlopicki, A. Marcinek, J. Gebicki, J. Wietrzyk, S. Egyhazi, A. Azimi, S. Ghasghgaei, M. Frostvik Stolt, C. Hertzman Johansson, J. Hansson, J. D. Delage, H. Li, H. Lu, L. H. Cazin, J. P. Vannier, L. Drouet, E. Dupuy, J. Soria, R. Varin, C. Soria, J. Castle, S. Kreiter, J. Diekmann, M. Lower, N. van der Roemer, J. de Graaf, S. Selmi, M. Diken, S. Boegel, C. Paret, M. Koslowski, A. N. Kuhn, C. M. Britten, C. Huber, O. Tureci, U. Sahin, G. Procopio, E. Verzoni, I. Testa, F. de Braud, S. Misale, R. Yaeger, S. Hobor, E. Scala, M. Janakiraman, D. Liska, E. Valtorta, R. Schiavo, M. Buscarino, G. Siravergna, K. Bencardino, A. Cercek, C. Chen, S. Veronese, C. Zanon, A. Sartore-Bianchi, M. Gambacorta, M. Gallicchio, E. Vakiani, V. Boscaro, E. Medico, M. Weiser, S. Siena, F. di Nicolantonio, D. Solit, A. Bardelli, M. F. Burbridge, S. P. Dovat, C. Song, K. J. Payne, L. Yang, A. Cree, M. Glaysher, L. Bolton, P. Johnson, N. Atkey, C. Torrance, T. A. Bogush, E. A. Dudko, A. S. Shaturova, M. V. Tikhomirov, E. A. Bogush, B. E. Polotsky, S. A. Tjulandin, M. I. Davydov, C. Hertzman Johansson, A. Azimi, M. Pernemalm, Y. Pawitan, M. Frostvik Stolt, V. Lazar, J. Lundeberg, J. Lehtio, S. Egyhazi, J. Hansson, A. Rasul, T. Ma, S. A. Dyshlovoy, I. Naeth, S. Venz, S. N. Fedorov, L. K. Shubina, V. A. Stonik, S. Balabanov, F. Honecker, P. Kongpracha, R. Tohtong, V. Demidkina, V. A. Kudryavtsev, A. E. Kabakov, T. Golan, D. Atias, I. Barshack, C. Avivi, R. S. Goldstein, R. Berger, S. Ben-Arieh, D. Urban, N. Maimon, R. Leibowitz-Amit, D. Keizman, H. Biran, M. Mishaeli, A. Onn, M. Gottfried, S. Saraswati, S. S. Agrawal, P. Raval, M. Patel, L. Ganure, J. H. Hanen, B. H. K. Sonia, M. Aya, H. Zohra, M. Touhami, X. Cheng, T. Y. Shi, L. Yang, G. Yang, X. Y. Tu, X. H. Wu, Q. Y. Wei, H. Benboubker, B. Q. Zheng, Y. Q. Shi, X. H. He, L. H. Liang, G. M. Saied
Journal: Annals of Oncology (2012)
Dear Sir:
Authors: J. L. Williams
Journal: JAMA (1891)

—At bottom of page 21, ofThe Journalof July 4, is an item headed "The oldest and largest Medical Society in the United States." The Massachusetts Medical Society, founded in 1781, and now having about 1800 members, might perhaps come nearer to that mark than the Society named in the item. Respectfully, Boston, July 7, 1891.
Insulin pump treatment of diabetes. Decision-making without definitive data
Authors: P. Felig
Journal: JAMA (1983)

THE ADVENT of treatment regimens involving the administration of insulin by portable pump<sup>1,2</sup>has added a new dimension to the decision-making process regarding the ambulatory treatment of the insulin-dependent diabetic. Briefly, such regimens involve the continuous subcutaneous infusion of rapid-acting (regular) insulin in basal amounts plus patient-activated bolus doses of insulin delivered by the pump before meals.<sup>3</sup>Adjustments in the basal or bolus doses of insulin are made on the basis of capillary blood glucose measurements performed by the patient on blood samples obtained by finger pricking several times per day.<sup>3</sup>Although expensive ($1,100 to $2,500 per unit), the pumps are readily obtainable from a number of manufacturers in the United States,<sup>3</sup>and their use in community-based clinical practice has rapidly increased within the past two years.<sup>4</sup> The enthusiasm generated by reports of normal or near-normal blood glucose levels in pump-treated patients and the evidence
Current Cytogenetic Methods for Detecting Exposure and Effects of Mutagens and Carcinogens
Authors: Adayapalam T. Natarajan, Jan J. W. A. Boei, Firouz Darroudi, Paul C. M. Van Diemen, Fernando Dulout, M. Prakash Hande, Adriana T. Ramalho
Journal: Environmental Health Perspectives (1996)
Schweizerische Med Wochenschrift, Basel
Journal: JAMA (1964)

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