tbuckley/cabot-search huggingface dataset:
A phase I study of concurrent pemetrexed (P)/cisplatin (C)/radiation (RT) for unresectable stage IIIA/B non-small cell lung cancer (NSCLC)
Authors: A. M. Brade, A. Bezjak, R. MacRae, S. A. Laurie, G. R. Pond, L. Wang, C. Dick, A. Afinec, N. Iscoe, F. A. Shepherd
Journal: Journal of Clinical Oncology (2008)

7550 Background: Concurrent chemoradiation is standard of care for most patients with unresectable stage III A/B NSCLC but no standard chemotherapy regimen/schedule has been established. A 3rd generation agent plus C provides maximal activity in stage IV NSCLC but to date, no 3rd generation agent is tolerable at full dose combined with RT and C. Pemetrexed/Cisplatin (PC) has shown activity in the stage IV setting and full dose P plus RT or RT/carboplatin appears tolerable. Methods: Starting Jan 30/06 (completed June 18/07), 13 patients with unresectable stage IIIA/B NSCLC were entered on four dose levels of a phase I trial evaluating PCRT (last follow-up Nov 8, 2007). Eligibility: < 5% weight loss; ECOG PS 0/1; no malignant effusions; FEV1 >1.3 l; adequate organ function. Pts received PC (Dose levels 1–3: P 300, 400 or 500 mg/m2 day 1, C 25 mg/m2 days 1–3; Dose level 4: P 500 mg/m2 day 1, C 20 mg/m2 days 1–5) q21 days x 2 concurrent with RT (61 - 66 Gy in 6 - 6.5 weeks) followed by PC alone x 2 q21 days (P 500 mg/m2 day 1, C 75 mg/m2 day 1). Dose escalation was governed by acute dose limiting grade 3/4 toxicities (DLT) delaying RT or PC (RT > 1 week, cycle 2 or 3 PC > 2 weeks). Results: 13 patients were accrued (Dose levels 1/2/3/4: 3/3/4/3). Demographics: median age - 64 years [range 47–74]; stage IIIA/B - 6/7; PS 0/1 - 4/9; median radiation dose - 64 Gy [range 60.5–66]. One patient had dose reduction of C for cycles 3 and 4 (elevated creatinine), cycles 3 and 4 were omitted for 2 (1 refusal; 1 cisplatin allergy). No DLT were observed. Neutropenia grade 3/4/febrile: 2/2/0 pts. Grade 3 esophagitis: 1 pt. Other grade 3 treatment-related toxicities were uncommon: pneumonitis (1); hypertension (2); diarrhea (1); anemia (1); hyperglycemia (1); hypophosphatemia (1); thrombocytopenia (1). Two pts required dilation for late (grade 3) esophageal stricture.12/13 pts achieved partial response (RECIST) after independent review. Disease progression has occurred in 5 pts (local - 1/13, distant - 5/13). Dose level 4 was recommended for phase 2 study. Conclusions: Full dose PC and full dose concurrent RT is well tolerated and active in stage III/B NSCLC. P is the first 3rd generation cytotoxic found to be tolerable at full dose with concurrent C/RT. A phase II study evaluating dose level 4 is accruing. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Expert Testimony Other Remuneration Eli Lilly Eli Lilly
Patients' competence to complete advance directives can be easily assessed
Journal: BMJ (1999)

Exercise is the answer for stress incontinence Urinary incontinence is a common condition in women, causing withdrawal from physical activities and reduction in quality of life.The most common type of urinary incontinence in women is genuine stress incontinence, with pregnancy and childbirth being the main cause.On p 487 Bø et al report the results of a 6 month comparison of the three most commonly recommended conservative treatments-pelvic floor exercises, electrical stimulation, and vaginal cones-in over 100 women with stress incontinence.Pelvic floor exercises were superior to the other methods in increasing strength of the pelvic floor muscles and reducing leakage; they were also well tolerated and had no side effects.
Immunopotentiation with levamisole in resectable bronchogenic carcinoma: a double-blind controlled trial; Study Group for Bronchogenic Carcinoma.
Journal: BMJ (1975)

A long-term multicentre double-blind study was designed to test the immunotropic effects of levamisole in patients undergoing operation for primary bronchial carcinoma. They received levamisole 50 mg three times a day by mouth or placebo for three days every fortnight, starting three days before surgery. Unless there was clinical evidence of recurrence, cytostatic drugs, corticosteroids, and radiotherapy were prohibited. In the 111 patients who have been followed up for one year the incidence of side effects was similar in both groups. Recurrences occurred in 10 out of 51 patients (seven deaths) receiving levamisole and in 20 out of 60 (12 deaths) receiving placebo. Further analysis showed that there were fewer recurrences on levamisole in patients with squamous cell carcinomas and medium and large primary tumours and fewer suspected and proved recurrences and deaths from metastases on levamisole in patients with extended tumours. Distant recurrences tended to be less common with levamisole, whereas the disease-free interval in relapsing patients was almost identical in the two groups. These interim results show that levamisole seems to exert its beneficial effect by preventing immunosuppression due to surgery.
Endocrinology
Authors: M. L. Nusynowitz
Journal: JAMA (1978)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dipyridamole-Induced Myocardial Ischemia-Reply
Authors: Theodore N. Keltz
Journal: JAMA (1988)

<h3>In Reply.</h3> —We read the letter by Drs Castelló and Hidalgo with great interest. Their broader experience confirms our observation that 4% to 5% of patients awaiting coronary revascularization will develop myocardial ischemia after receiving 100 mg of dipyridamole orally. The observed association of this clinical phenomenon with epicardial collaterals is further supported by a study by Chambers and Brown.<sup>1</sup>They used a stepwise multivariate logistic regression analysis to examine the relationship of angiographic findings, hemodynamic changes, thallium imaging results, and demographic variables to the development of dipyridamole-induced ischemia in 46 patients with coronary artery disease. The presence of coronary collaterals was the strongest predictor. It seems clear that patients with collaterals are at risk for the development of dipyridamole-induced myocardial ischemia. This relationship makes a true coronary steal the likely underlying mechanism. Although aminophylline is certainly the "antidote" for side effects of dipyridamole therapy, sublingual nitroglycerin is immediately
ISOTOPE STUDIES OF SKELETAL METABOLISM
Journal: JAMA (1960)

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The Ear: Its Anatomy, Physiology, and Diseases.
Authors: None C. E. W.
Journal: JAMA (1884)

The author, in the second edition, has evidently spared no pains both by careful compilation and original research, to bring the work fully up to date. The part on diseases and treatment is arranged under seven sections, considering first the examination of the patient, then the various diseases according to their anatomical location, and lastly a section on the methods of relief and education of deaf mutes and partially deaf children.
ARE OUR BACTERIOLOGIC METHODS COMPLETE AND SCIENTIFIC?
Journal: JAMA (1897)

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On Responsibility
Authors: Charles D. Aring
Journal: JAMA (1972)

Since I was free to do as I please, I was responsible for what it was that I was pleased to do. — Carl Becker A sense of responsibility is not innate. In all human endeavor desirable characteristics do not occur in pure culture, neither do they spring up fully developed. They are under constant modification and development in the process of living. Responsibility must be learned, and, like all learning, it is likely to begin with the dawn of consciousness. Parents who are responsible with their children pass on the germ from which the trait can develop. They are supported by teachers and successively by others as the child moves into adulthood and grows in understanding. The human organism is under a constant bombardment of innuendo and direction. In a sense, developing man is offered the tools with which to model his character. It behooves all of those in
Les principales positions utilisées en radiographie. (Technique, indications, résultats).
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Spontaneous abortions in hospital sterilising staff.
Journal: BMJ (1983)

With regard to oral treatment, advice in the British National Formulary lacks consistency.In the main text we read, "In patients with moderate heart failure a loading dose is not required and a satisfactory concentration can be achieved over a period of about a week of 125-250 j&g twice daily which can then be reduced."Whereas, in the summary we read: "Dose by mouth 250 /eg twice daily until digitalised then 125-500 4g daily."This ambiguity could lead to the prescription of 500 ,ug daily for a week, which would result in a potentially toxic total dose of 3-5 mg.We appreciate that general cautionary advice on the use of digoxin is included but think this entry in the British National Formulary needs revision.Simplified instruc- tions on loading doses as discussed by Jelliffe4 could then be supplemented by fuller guidance on estimation of maintenance dose.5
Der operierte Magen.
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Francis Home (1719-1813), practitioner of experimental medicine
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Atonement
Authors: O Paltiel
Journal: Annals of Internal Medicine (1996)

On Being a Doctor1 September 1996AtonementOra Paltiel, MDCM, MSc, FRCPCOra Paltiel, MDCM, MSc, FRCPCHadassah University Hospital, Jerusalem 91120, IsraelSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-5-199609010-00010 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail I trained in a large university teaching hospital in Montreal. Our patient population was cosmopolitan. We learned how to interpret the silence of one ethnic group, the screams of another. The atmosphere was a tolerant one. Empathy abounded, yet patients had to adapt to us, come on time, wait their turn, and accept any piece of information or advice that we, with our white coats, had to offer. We supplied them with the facts, often without being asked. Although patient autonomy was respected, there was no question about who had the upper hand. Medicine and its practitioners were from the ... Author, Article, and Disclosure InformationAuthors: Ora Paltiel, MDCM, MSc, FRCPCAffiliations: Hadassah University Hospital, Jerusalem 91120, IsraelCorresponding Author: Ora Paltiel, MDCM, MSc, FRCPC, Department of Social Medicine, Hadassah University Hospital, POB 12000, Jerusalem 91120, Israel. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited by“Death is inevitable – a bad death is not” report from an international workshopTruth-Telling in a Culturally Diverse WorldA physician charter on medical professionalism: a challenge for medical educationOld Lives TalesBarriers to Optimum End‐of‐life Care for Minority Patients 1 September 1996Volume 125, Issue 5Page: 416-417KeywordsCancer chemotherapyChemotherapyChildrenDiffuse large B-cell lymphomaDrugsHematology and oncologyLaparotomyLymphomaPatient advocacy ePublished: 15 August 2000 Issue Published: 1 September 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Presse Médicale, Paris
Journal: JAMA (1965)

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Contraception
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Erratum: “A Case–Control Study of Maternal Polybrominated Diphenyl Ether (PBDE) Exposure and Cryptorchidism in Canadian Populations”
Authors: Cynthia G. Goodyer, Shirley Poon, Katarina Aleksa, Laura Hou, Veronica Atehortua, Amanda Carnevale, Gideon Koren, Roman Jednak, Sherif Emil, Darius Bagli, Sumit Dave, Barbara F. Hales, Jonathan Chevrier
Journal: Environmental Health Perspectives (2018)

[This corrects the article DOI: 10.1289/EHP522.].
Hepatobiliary scan and acute cholecystitis: Bayesian analysis of data
Authors: L. Barenholtz
Journal: JAMA (1981)

<h3>To the Editor.—</h3> Freitas and Gulati (1980;244:1585) have recently demonstrated that hepatobiliary scanning (HBS) was 97% sensitive and 87% specific for acute cholecystitis (AC) in a study population of 179 patients in whom the diagnosis of AC was either confirmed or ruled out by independend means. Test results on these 179 patients fell into the following categories: 56 true-positive (TP), 16 false-positive (FP), 105 true-negative (TN), and 2 false-negative (FN). Sensitivity was therefore TP/(TP+FN) or 97% and specificities, TN/(TN+FP) or 87%. These figures are perfectly valid characteristics of the test itself, but I believe that the authors could have better described the clinical utility of HBS in their hands by presenting additional analysis of the data according to Bayes' theorem. The predictive value of a positive (abnormal) test result is expressed by TP/(TP+FP). In this case the figure is 77%. The predictive value of a negative (normal) test result is