Cortisol Transport and Disappearance
Authors: W. R.  BEISEL, V. C.  DIRAIMONDO, P. H.  FORSHAM
Journal: Annals of Internal Medicine (1964)

Article1 April 1964Cortisol Transport and DisappearanceW. R. BEISEL, M.D., V. C. DIRAIMONDO, M.D., P. H. FORSHAM, M.D.W. R. BEISEL, M.D.Search for more papers by this author, V. C. DIRAIMONDO, M.D.Search for more papers by this author, P. H. FORSHAM, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-4-641 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptReversible binding by plasma proteins appears fundamental in regulating the availability of circulating cortisol*for physiologic activity in tissues, for inactivation by the liver, or for excretion by the kidneys. Two plasma protein components are involved in binding nonmetabolized cortisol (1-3). At physiologic concentrations, plasma cortisol is bound predominantly by an alpha globulin termed corticosteroid-binding globulin (CBG) (1) or transcortin (3). 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To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Frederick, Maryland and San Francisco, CaliforniaFrom the United States Army Medical Unit, Walter Reed Army Medical Center, Fort Detrick, Frederick, Maryland, and the Metabolic Unit, University of California Hospitals, San Francisco, California.Presented at the Forty-fourth Annual Session of the American College of Physicians, Denver, Colorado, April 1-5, 1963.Requests for reprints should be addressed to Lt. Col. W. R. Beisel, M.D., United States Army Medical Unit, Walter Reed Army Medical Center, Fort Detrick, Frederick, Maryland .*11 beta, 17 alpha, 21 trihydroxy-4-pregnene-3,20 dione, also termed compound F or hydrocortisone. 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