tbuckley/cabot-search huggingface dataset:
Effect of Mineral Dusts on Metabolic Cooperation between Chinese Hamster V79 Cells in Vitro
Authors: M. Chamberlain
Journal: Environmental Health Perspectives (1983)

The mode of action of inorganic fibers as carcinogens is unknown. There is conflicting evidence whether they act by inducing lesions in DNA, such as initiating carcinogens, or alternatively act as promoters of carcinogenesis. Recent evidence has suggested that promoters inhibit the process of cell-to-cell chemical communication known as metabolic cooperation. Chinese hamster V79-4 cells in culture exhibit metabolic cooperation which can be blocked by the promoter tetraphorbol-13-acetate (TPA). Three kinds of mineral dust were tested to determine whether or not they could interfere with the intercellular communication. The three dusts studied were: amosite, a fibrous asbestos from the Union Internationale Contre le Cancer (UICC) standard reference series, which is a typical carcinogenic fibrous dust inducing pleural tumors following intrapleural injection into rats; ball-milled amosite, a nonfibrous dust derived from UICC amosite by ball-milling, which has the physical properties characteristic of a noncarcinogenic dust; and Min-U-Sil silica, a widely available sample of fibrogenic quartz which does not induce pleural tumors following intrapleural injection into rats. The results demonstrated that metabolic cooperation between V79-4 cells cannot be reduced by carcinogenic asbestos fibers or by relatively large numbers of nontoxic dust particles. It is concluded that if inorganic fibers promote carcinogenesis, then they do not operate by blocking metabolic cooperation.
TYPHOID FEVER IN CHICAGO.
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effect of inhaling heated vapor on symptoms of the common cold
Authors: G. J. Forstall
Journal: JAMA (1994)

<h3>Objective.</h3> —To test the efficacy of steam inhalation in treating common cold symptoms. <h3>Design.</h3> —An in vitro study determined the temperature that inactivated rhinovirus: a temperature of 43°C lasting at least 1 hour was needed. We then conducted a double-blind, placebo-controlled, randomized in vivo study. <h3>Setting.</h3> —The virology laboratory and the outpatient department of the Cleveland (Ohio) Clinic Foundation. <h3>Patients.</h3> —Sixty-eight Cleveland Clinic employee volunteers with symptoms of the common cold at the time of enrollment. <h3>Intervention.</h3> —A single 60-minute treatment was given to the volunteers. The steam treatment group (n=32) received 40 L/min of heated saturated air that raised the intranasal temperature to 43°C. The placebo group (n=36) received 2 L/min of ambient air at 20°C to 24°C. <h3>Main Outcome Measures.</h3> —Subjective symptom scores for nasal congestion, nasal drainage, and sneezing and objective measures of nasal resistance were studied during a 7-day follow-up observation period. <h3>Results.</h3> —There were no significant differences in daily symptom scores between the groups (<i>P</i>=.59 to.83). The only statistically significant differences between the groups were lower nasal resistances at baseline in the steam group (<i>P</i>=.04) and percent improvement in nasal resistance favoring the placebo group on day 7 (<i>P</i>=.01). However, these differences were of questionable clinical significance. <h3>Conclusion.</h3> —We conclude that steam inhalation treatment had no beneficial effect on the cold symptoms of our volunteers. (<i>JAMA</i>. 1994;271:1109-1111)
Hepatitis A Associated With Consumption of Frozen Strawberries—Michigan, March 1997
Journal: JAMA (1997)

In March 1997, a total of 153 cases of hepatitis A were reported in Calhoun County, Michigan (1990 population: 136,000); 151 case-patients have been students or staff of schools in four different school districts. Investigation by public health officials has not implicated a single event, foodhandler or contaminated water as a source for the outbreak. However, most case-patients ate lunch in schools, and preliminary analysis of both a case-control and cohort study conducted in two different school districts established a strong association between illness and consumption of food items containing frozen strawberries. This report presents the preliminary findings of the ongoing outbreak investigation.
Individualized Developmental Care
Authors: Gerald B. Merenstein
Journal: JAMA (1994)

Many factors have improved the infant and neonatal mortality in this country. The evolution of nurseries for premature newborns into modern neonatal intensive care units (NICUs) and technological advances used in NICUs have certainly contributed to the reduction in mortality for all birth-weight/gestational-age categories. This reduction in mortality has been most dramatic in recent years for very low-birth-weight (&lt;1500 g) and extremely low-birth-weight (&lt;1000 g) infants. Mortality has traditionally been the tool used to evaluate the success of NICUs with these small infants. However, today both short-term and long-term morbidity and neurodevelopmental outcome must be evaluated when assessing any new intervention used in the NICU. See also p 853. The acceptance of new innovations in care in perinatal medicine has an unfortunate history. Unproven therapies or therapies with inappropriate risks have been adopted, while proven therapies remain underused. In the 1940s and 1950s, an epidemic of blindness, due to retinopathy
NIH Technology Assessment Conference Statement on Bovine Somatotropin
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dermatology
Authors: Jeffrey S. Dover
Journal: JAMA (1989)

Two topical medications have stimulated a great deal of attention among physicians, the public, and the media: minoxidil and tretinoin, both of which are aimed at retarding or reversing the inevitable aging process. Topical 2% minoxidil is the first medical treatment documented to stimulate hair growth in male pattern baldness (androgenetic alopecia). Enthusiasm for this treatment seems to be exceeding its demonstrated clinical effectiveness. Studies of the ability of topical minoxidil to grow terminal (coarse, dark) scalp hair have been ongoing since 1979, when oral minoxidil was noted to induce hypertrichosis in patients treated for hypertension. There is no doubt that topical minoxidil is safe and can induce the growth of terminal hairs in some balding men. However, the more important question is not whether the hair growth is statistically significant but whether it causes satisfactory cosmetic improvement. Topical minoxidil solution, in concentrations ranging from 1% to 5%, has been
NASAL POLYPUS.
Authors: CUNDELL JULER
Journal: JAMA (1899)

Among growths found in the nose are polypi, innocent pedunculated mucous growths, often resembling a butter-bean in shape, and having the consistency of an oyster with the moist glistening surface of grape pulp. Polypi, in the majority of cases, spring from the mucous membrane adjacent to or covering the middle turbinated body. They very rarely spring from the superior turbinated body or septum; we may see them in the nose, having their origin in the accessory cavities, notably the antrum of Highmore. They are sometimes seen in children, but commonly in adults, in the male more frequently than in the female. As to their etiology, Bosworth describes the mucous covering of the middle turbinal area as becoming "water soaked," and subsequent pyriform growth is accounted for by anterior stenosis, and suction action in hawking, sniffing, and nose-blowing efforts. Polypi are often the accompaniment of hypertrophic catarrh, especially in such cases
Possible diphenylhydantoin-induced arrhythmia in hypothyroidism
Authors: M. Fulop
Journal: JAMA (1966)

WE HAVE RECENTLY seen a patient with hypothyroidism and heart disease who developed supraventricular tachycardia following the administration of diphenylhydantoin. The use of this drug for treatment of cardiac arrhythmias has received favorable attention<sup>1,2</sup>and so the circumstances in this case are of interest. <h3>Report of a Case</h3> A 53-year-old white woman with rheumatic heart disease had a mitral commissurotomy in 1954. Although euthyroid, she was given an ablative dose of sodium iodide 1131 in 1955 in an effort to slow her heart rate. With the development of symptomatic hypothyroidism, she was given thyroid replacement therapy. She took sodium levothyroxine (Synthroid) (0.15 mg) daily and quinidine sulfate (0.3 gm) three times a day during the year before the present hospitalization, and digoxin (0.25 mg) daily during the preceding month. She was hospitalized in May 1965 because of the renewed appearance of atrial flutter with 2:1 to 4:1 atrioventricular (AV)
Expanding psychiatric service in a hospital emergency room
Authors: W. S. Barry
Journal: JAMA (1979)

Senior medical residents were used to extend psychiatric coverage in a busy hospital emergency room. Their service was supported by the backup consultation of senior psychiatric physicians. The medical residents worked in conjunction with psychiatric residents to provide 24-hour daily emergency psychiatric service to more than 350 patients during a 12-month period. There were no significant differences in the demographic composition of the patient population seen or in the disposition of individual patients made between the medical and psychiatric residents. The hospital was able to expand its psychiatric service in the emergency room without major increases in cost. The medical residents benefited by experiencing a more diversified patient care training program, and they earned a modest supplement to their house officer salary. (<i>JAMA</i>242:1394-1395, 1979)
Polyarteritis Nodosa
Authors: John H Stone
Journal: JAMA (2002)

Polyarteritis nodosa (PAN) is regarded rightly as the grandfather of the vasculitides. In this Grand Rounds, the case of a 30-year-old man with a 12-year illness is described. The patient presented with daily fevers, tachycardia, and cutaneous ulcers on his distal extremities. He eventually developed mononeuritis multiplex. Because of the striking pattern of his fevers, he was diagnosed for many years as having adult-onset Still disease. Following the addition of daily cyclophosphamide to his long-standing regimen of prednisone, the patient's disease entered remission for the first time in more than a decade. He was ultimately able to discontinue all of his immunosuppressive medications. The case is discussed in the context of the first patient ever described with PAN, the classic report of Kussmaul and Maier.
SAT0236 Prevalence of Comorbidities and Evaluation of Their Screening in Spondyloarthritis: Results of the International Cross-Sectional ASAS-Comospa Study
Authors: A. Moltό, A. Etcheto, D. van der Heijde, R. Landewé, F. van den Bosch, M. Dougados
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Increased risk of cardio-vascular disease, and osteoporosis is documented in SpA. Some of these co-morbidities (e.g. cardiovascular disease risk) are subject to recommendations, with specific components relevant to rheumatic inflammatory diseases (e.g. yearly evaluation of BP, LDL-cholesterol). However, it is known that a gap exists between recommendations and their implementation in practice. <h3>Objectives</h3> To evaluate: 1) the prevalence of SpA co-morbidities and risk factors for these comorbidities in different countries worldwide, 2) the gap between available recommendations and daily practice concerning prevention/management of these co-morbidities and 3) the number of risk factors detected due to the present initiative <h3>Methods</h3> International, cross-sectional study of consecutive SpA patients in routine care. Data comprise SpA characteristics, plus relevant cardiovascular, infection, cancer, osteoporosis and gastro-intestinal disorders. <h3>Results</h3> Twenty-two participating countries (from 4 continents) included 3984 patients. Age: 44±14 years, disease duration 8±9 years, male gender: 65%, past or current axial (89%) and articular peripheral (56%) involvement; ASDAS-CRP: 2.0±1.1, BASFI 3.2±2.7, NSAID intake during last 3 months 68% and any past or current intake of methotrexate (33%), sulfasalazine (44%) or biologicals (44%). The most frequent diseases (past or current) found were osteoporosis (13%), gastro-duodenal ulcus (11%), cardiovascular events (myocardial infarction or stroke) (4%), solid cancers (3%), and hepatitis B infection (3%). The most frequent risk factors for these diseases were hypertension (34%), smoking (current or past (&lt;3years)) 29%, dyslipidaemia (27%) and family history of cardiovascular disease and breast cancer (each 15%). Substantial inter-country variability was observed for the screening of co-morbidities (e.g. LDL-cholesterol measured at least in the last year from 8% (Taiwan) to 98% (Germany) or dentist visit in the last year from 0% (China) to 85% (Netherlands)). Evaluation of comorbidities and risk factors as part of this study unveiled previously undetected abnormalities [e.g. elevated blood pressure (14%), hyperglycemia (4%)] and emphasized the sub-optimal management of co-morbidities. <h3>Conclusions</h3> This study suggests a) a high prevalence of co-morbidities in SpA, b) a substantial inter-country variability c) a highly variable detection of relevant risk factors. This study strongly suggests that rigorous application of systematic evaluation of co-morbidities may permit earlier detection, which ultimately may result in an improved outcome of patients with SpA. <h3>Acknowledgements</h3> Study was conducted under the umbrella of ASAS and financially supported by unrestricted grants from Abbvie, Pfizer and UCB. <h3>Disclosure of Interest</h3> None declared
Isomaltose Intolerance Causing Decreased Ability to Utilize Dietary Starch
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Facts and artifacts about anemia and preterm delivery
Authors: E. Lieberman
Journal: JAMA (1990)

<h3>In Reply.—</h3> Although federal anti-kickback laws and the Inspector General's "safe harbor" guidelines apply to both Medicare and Medicaid, Rep Fortney Stark's bill does not. While my first mention of the bill (p 390) is limited to Medicare, the cited passage (p 391) wrongly adds Medicaid. Common law has not yet addressed physician investment and self-referral to ancillary facilities for the same reason that we do not yet have final legislation: the phenomenon itself is new, as recent cost-containment programs shift more care to outpatient settings and increasingly focus on physicians' incomes.<sup>1</sup> Abusive self-referral does cause injuries. Aside from the obvious harms of money wasted on needless and possibly iatrogenic tests or treatments, the deeper injury may be to the patient's trust when he or she discovers that the magnetic resonance imaging scan received at 2 AM could have been done more conveniently and less expensively by an identical,
Little Boy
Authors: Kristin G. Kelly
Journal: Annals of Internal Medicine (2014)

Ad Libitum7 January 2014Little BoyKristin G. Kelly, PhDKristin G. Kelly, PhDFrom Gainesville, Georgia.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M13-0661 Audio Reading - “Little Boy” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Little Boy," by K.G. Kelly. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail I was there in DecemberWhen you first came homeRed tomato skinStretched tight, so thinForehead mad andDeeply old man wrinkled when thatMilk just wouldn't comeI was afraid we wouldSlice through thatSoft fruit filmBy accidentAfraid you'd burstAt two you woreJingle bells on yourStride Rites soWe'd alwaysKnow where you went.Now you sit inLosers’ basementsAll day longSipping hydrocodone,Smoking potHanging out with boysWho like you when you pay themAnd putDrano in your drugsI hope that in the colorsSizzling in your brain nowAre still glimpses of hospital lightsFluorescent loving facesIn the ... Author, Article, and Disclosure InformationAffiliations: From Gainesville, Georgia.Current Author Address: Kristin G. Kelly, PhD; e-mail, kristin.[email protected]edu. PreviousarticleNextarticle Advertisement Audio Reading - “Little Boy” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Little Boy," by K.G. Kelly. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 7 January 2014Volume 160, Issue 1Page: 69KeywordsBrainDrugsMilk ePublished: 7 January 2014 Issue Published: 7 January 2014 Copyright & PermissionsCopyright © 2014 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
CONSERVATIVE GYNECOLOGY.
Authors: W A Verdier
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fumbled Handoffs
Authors: Kenneth M. Kessler
Journal: Annals of Internal Medicine (2005)

Letters4 October 2005Fumbled HandoffsKenneth M. Kessler, MDKenneth M. Kessler, MDFrom University of Miami School of Medicine, Miami, FL 33101.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-143-7-200510040-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:After reading Dr. Gandhi's discussion (1) of “fumbled handoffs,” I was concerned that I had a very different perspective of the case. I asked my wife, a pediatric radiologist, her thoughts about an elderly man with a history of alcohol abuse who presents with weight loss and cough. She immediately replied that her major concern was tuberculosis. It was reassuring that she concurred with my initial thoughts but a bit troubling that someone who had been remote from clinical adult medicine for more than 2 decades could “nail” the diagnosis when the clinicians caring for the patient ...Reference1. Gandhi TK. Fumbled handoffs: one dropped ball after another. Ann Intern Med. 2005;142:352-8. [PMID: 15738454] LinkGoogle Scholar Author, Article, and Disclosure InformationAuthors: Kenneth M. Kessler, MDAffiliations: From University of Miami School of Medicine, Miami, FL 33101.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoFumbled Handoffs: One Dropped Ball after Another Tejal K. Gandhi Fumbled Handoffs Tejal K. Gandhi Fumbled Handoffs Darius A. Rastegar Metrics 4 October 2005Volume 143, Issue 7Page: 542KeywordsAlcoholismChartsComputed axial tomographyConflicts of interestDiagnostic imagingElderlyNursing homesPrevention, policy, and public healthRadiologistsWeight loss ePublished: 4 October 2005 Issue Published: 4 October 2005 Copyright & PermissionsCopyright © 2005 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...