tbuckley/cabot-search huggingface dataset:
Mutagenic Activity of Heterocyclic Amines in Cooked Foods
Authors: James S. Felton, Mark G. Knize, Frank A. Dolbeare, Rebekah Wu
Journal: Environmental Health Perspectives (1994)

Mutagenic heterocyclic amines are generated in foods when they are cooked at temperatures over 1 50°C.These compounds are present from 0.1 to 50 ppb, depending on the food and cooking conditions.These heterocyclic amines are not only present in cooked red meat, fish, and chicken, but are also present at lower levels in baked and fried foods derived from grain.Mutagenicity of fried beef hamburgers cooked at 230°C is 800 ± 37 TA98 revertants per gram cooked weight.We measured 2-amino-3,8-dimethylimidazo[4,5-flquinoxaline (MelQx), 2-amino-3,4,8-trimethylimi- dazo[4,5-f]quinoxaline (DiMelQx), and 2-amino-3-methylimidazo[4,5-flquinoline (IQ) formation at this temperature and found 3.0 ± 2.0, 1.0 ± 0.18, and 0.06 ± 0.03 ng/g, respectively.2-amino-1-methyl--phenylimidazo[4,5-blpyridine (PhIP) was found at a higher concentration of 9.6 ng/g.In our laboratory we have shown these heterocyclic amines are capable of producing both reverse and forward mutations in Salmonella bacteria and for- ward mutations in Chinese hamster ovary cells (CHO).We have also been able to show a statistically significant increase in mutations in the pan- creas of the "mutamouse" following PhIP exposure.The pancreas also shows relatively high DNA binding compared to other organs in the mouse.The number and type of mutations depend on the repair capacity of the cells for both Salmonella and CHO.In Salmonella the mutations are primarily 2-base deletions when the cells lack uvrB repair, but mutations are more complex (larger deletions and insertions) but lower in frequency when repair is functional.Efforts are now under way to assess specific sequence changes in the aprt gene in mutant CHO cells.-
Leads from the MMWR
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Cover
Authors: Elisa Buono
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 249: Combination of ONC201 with radiation exhibits synergistic efficacy in high grade gliomas and other advanced cancers
Authors: Rohinton S. Tarapore, Sachin Jhawar, Mark Stein, Andrew Zloza, Sabine Mueller, Jie Zhang, Francesca Amoroso, Ian Mills, Wolfgang Oster, Joshua Allen
Journal: Cancer Research (2019)

Abstract Background: Radiation is widely administered in many treatment settings for solid tumors. ONC201 is the first small molecule DRD2 antagonist for oncology that is being investigated in advanced cancer clinical trials as a single agent. ONC201 has exhibited preclinical and clinical anti-tumor activity in high grade gliomas and its immunostimulatory activity involving natural killer (NK) cells has been recently reported. Given that ONC201 exhibits broad synergy with anti-cancer drugs, excellent safety, and single activity in tumor types where radiation is used routinely, we evaluated the combination of ONC201 with radiation. Methods: Cell viability was evaluated in human and/or mouse breast, prostate and high grade glioma cell lines in response to ONC201 (1 - 10uM), radiation (2- 10 Gy), or the combination. Incubation times ranged from 24 to 96 hours and the sequence of the two agents in combination was varied. Results: Cell viability assays for ONC201 in combination with radiation in breast or prostate cancer cell lines revealed a cytotoxic response to the combination that was superior to either single agent. Western blot analysis of PC3 cells showed a synergistic induction of CHOP and ATF6 that are components of the integrated stress response. In glioblastoma or diffuse intrinsic pontine glioma (DIPG) cell lines, combination indices computed from cell viability experiments indicated modest synergy (~0.7 CI) for the combination ranging between 1-5 µM ONC201 and 2-10 Gy. In MDA-MB-468 breast cancer cells, Western blot analysis demonstrated a striking induction of PARP cleavage, a marker of caspase-mediated apoptosis, with 2 µM ONC201 in combination with 2 Gy radiation, whereas either single agent produced minimal PARP cleavage. In 4T1 murine triple-negative breast cancer subcutaneous tumors, the combination of oral ONC201 and radiation produced antitumor effects at subtherapeutic doses that required CD4+ T cells and NK cells. Conclusions: ONC201 combined with radiation produced additive or synergistic anti-cancer effects in high grade glioma, breast and prostate cancer in vitro and increased anti-tumor efficacy in an in vivo model of breast cancer that involved immune cells. Citation Format: Rohinton S. Tarapore, Sachin Jhawar, Mark Stein, Andrew Zloza, Sabine Mueller, Jie Zhang, Francesca Amoroso, Ian Mills, Wolfgang Oster, Joshua Allen. Combination of ONC201 with radiation exhibits synergistic efficacy in high grade gliomas and other advanced cancers [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 249.
Coloscopy
Authors: Robert Turell
Journal: JAMA (1974)

<h3>To the Editor.—</h3> Marks's (228:1411, 1974) very sensible article has stressed that the main indication for coloscopy is the failure of conventional sigmoidoscopy and roentgenography of the colon to establish a diagnosis. Coloscopy is unnecessary, "too costly," and a procedure not to be taken lightly. This point needs to be stressed because as a result of recent publicity, many clinicians have come to believe that coloscopy has supplanted roentgenography. The biopsy forceps used with coloscopy is too small in size and therefore incapable of removing tissue representative of the entire lesion. No pathologist can resolve the big issue (infiltration) on the basis of little superficial tissue; only total biopsy is the answer to this problem. Biopsy studies may show benignity near to an infiltrating cancer. Little, if any, mention has ever been made that coloscopists have missed known or existing cancers. Thus far, I have seen only one paper on
Widespread adenocarcinoma of the colon with survival of 28 years
Authors: M. Glasser
Journal: JAMA (1979)

APPROXIMATELY 40% of the 75,000 patients each year in the United States with colorectal cancer have conditions that are inoperable at the time of diagnosis.<sup>1</sup>Long-term survival or spontaneous regression of the disease is rare. Everson and Cole<sup>2</sup>found only seven cases of spontaneous regression from 1900 to 1966. These patients were followed up for periods of three to 18 years. Four additional Cases<sup>3-5</sup>with survival of from nine to 14 years have since been reported. We describe a 64-year-old man who survived widespread metastatic adenocarcinoma of the colon for 28 years. <h3>Report of a Case</h3> In June 1950, the patient, then 36 years old, was admitted to the Lawrence and Memorial Hospitals of New London, Conn, with periomphalic pain of one week's duration and intestinal obstruction. A laparotomy was performed on June 15, 1950; the operation report states: Lying in the lower portion of the ascending
QUACK METHODS IN HIGH PLACES.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The patient and diabetes. Impressions from dialogues
Authors: C. P. Kimball
Journal: JAMA (1972)

White, black, yellow, mulatto, chicano, Creole—respecter of no race or breed—rich, poor, bourgeois, laborer, banker, professor—no arbiter of caste or class—the genic substrate for the syndrome, diabetes mellitus, has become ubiquitous and in the best of us can be suspected as lying only dormant waiting for the right time—stress, duress, assault, catastrophe, tragedy, holocaust—to precipitate, exacerbate, fly out of control. And now, what infamy, treachery, disaster—accursed gene, source of blight, wrecker of fortunes and families, destroyer of mind and body, warper of life, unsparing of young or old—miserable paradox visited even unto the third generation and after—source of hope, inspiration, intrigue, elan vital for researcher, scientist, clinician who dare to penetrate behind the locked bands of its myth, to tamper with its ways, to bare its merciless bonds, to explain its why and wherefore, to bring relief—perhaps also fame—but relief, succor, aid, help, care, cure, alleviation, remediation, solace, freedom,
Great American Smokeout — November 19, 2015
Authors: Ahmed Jamal, David Homa, Erin O'connor, Stephen Babb, Ralph Caraballo, Tushar Singh, ; Hu, Brian King, Thomas Frieden, Harold Jaffe, Joanne Cono, Chesley Richards, Michael Iademarco, Sonja Rasmussen, Charlotte Kent, Jacqueline Gindler, Teresa Rutledge, Douglas Weatherwax, Soumya Dunworth, Teresa Hood, Martha Boyd, Maureen Leahy, Julia Martinroe, Stephen Spriggs, Moua Yang, Quang Doan, Phyllis King, Teresa Moreland, Terraye Starr, Timothy Jones, Matthew Boulton, Virginia Caine, Katherine Daniel, Jonathan Fielding, David Fleming, William Halperin, King Holmes, Robin Ikeda, Rima Khabbaz, Phyllis Meadows, Jewel Mullen, Jeff Niederdeppe, Patricia Quinlisk, Patrick Remington, Carlos Roig, William Roper, William Schaffner
Journal: MMWR Morbidity and Mortality Weekly Report (2015)

Sponsored by the American Cancer Society, the Great American Smokeout is an annual event that encourages smokers to make a plan to quit, or to plan in advance and quit smoking on that day, in an effort to stop smoking permanently (1).The 40th annual Great American Smokeout will be held on November 19, 2015.In the more than 50 years since the first Surgeon General's report on smoking and health, cigarette smoking among U.S. adults has been reduced by half.However, since 1964, an estimated 20 million persons have died because of smoking, which is the leading preventable cause of disease, disability, and death in the United States (2).About two out of three adult smokers want to quit smoking cigarettes, and more than half made a quit attempt in the preceding year (2).However, in 2014, an estimated 16.8% (approximately 40 million) of U.S. adults still smoke (3).Getting effective help through counseling and medications can increase the chances of quitting by as much as three-fold (4).
Patient-Initiated Laboratory Testing: No Gatekeeper, No Kidding
Authors: Herbert Kaplan
Journal: JAMA (1991)

<h3>To the Editor.—</h3> My first response to Dr Soloway's<sup>1</sup>Commentary was that this was some sort of medical spoof. This form of medical practice gives a new meaning to the term<i>catastrophic care</i>! Dr Soloway tells us about the proposed regulations whereby Medicare or Medicaid recipients could order tests on themselves as long as the expense is not billed to Medicare or Medicaid. But think of the expense involved in following up on the results of these tests. This will certainly be billed to Medicare, Medicaid, and everyone else. Rather than "applauding the inevitable," physicians should clench both fists and fight this folly.
Disease Alert
Authors: Christian G. Schrock
Journal: JAMA (1980)

<h3>To the Editor.—</h3> I have recently encountered three cases of serious illness in young women that have marked similarity. <h3>Report of Case.—</h3> Each patient was menstruating or had recently finished her menstrual period. Each had a watery diarrhea of 12 to 72 hours' duration. The patients were febrile (highest temperature in each case was 39 °C, 39 °C, and 41 °C). Suddenly, a shock syndrome developed, with obtundation and blood pressures typically in the 60 to 70/0 mm Hg range. Each patient had a remarkable degree of peripheral vasoconstriction with cold extremities and blue-appearing hands and feet. The skin had a diffuse blanching, erythematous appearance. Conjunctivae were hyperemic and matted. Two patients had 3- to 7-mm circular labial (genital) lesions consistent with herpes simplex genitalis. One had mouth lesions consistent with herpes gingivostomatitis. Leukocytosis was present, with marked left shift. The creatine phosphokinase (CPK) values were greatly elevated (up to
MINERAL METABOLISM DURING THE REPRODUCTIVE CYCLE
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Acute Pericarditis
Authors: JOHNSON MCGUIRE, J. HAROLD KOTTE, ROBERT A. HELM
Journal: Circulation (1954)

Statistical studies of the frequency of the different etiologic types of acute pericarditis may be misleading because of an increasing recognition of nonspecific pericarditis. In our experience this form is the most common in private practice, while on the wards of a general hospital, tuberculous pericarditis is the most frequent variety. Despite improvements in diagnostic technics there still remains a significant number of patients with acute pericarditis, the etiology of which cannot be categorized accurately. This latter group will be narrowed only after further clinical description and laboratory study. The diagnosis of nonspecific pericarditis should be made carefully because of similarity of its onset to that of myocardial infarction and its benign course with tendency to relapse. Tuberculous pericarditis merits early recognition because of the improved prognosis following prompt treatment. Rheumatic pericarditis is often a problem in children and adolescents and indicates serious cardiac involvement; in adults the clinical course is generally more benign. Pericarditis occurring in uremia and myocardial infarction is usually an incidental finding in the course of a more important disease. Pyogenic pericarditis is now a rare occurrence except in certain infectious states. The treatment of acute pericarditis has been considerably improved by the introduction of the antibiotic drugs. The judicious use of pericardial paracentesis may be life-saving in certain instances or it may yield diagnostic information from which effective therapy can be instituted.
Die Röntgenuntersuchung der Harnorgane: Lehrbuch.
Journal: JAMA (1953)

This brief monograph on roentgenologic examination of the urinary organs was intended as a textbook and as a guide to interpretation of urographic deformities caused by lesions in this tract. As the authors state, the circle of those interested would include not only urologists, but roentgenologists, internists, and various surgical specialists. The monograph contains only 323 illustrations, including drawings, abstract sketches, roentgenograms, and urograms. They portray the usual deformities seen with lesions in the urinary tract. The book is not a complete atlas of such deformities. It contains clinical discussions with most of the urograms, which take up a large part of the book, and offers additional information of questionable value to the main subject. While the text is written in an interesting and readable manner, it adds comparatively little to our present knowledge of the subject.
Nosocomial Hepatitis B Virus Infection Associated With Reusable Fingerstick Blood Sampling Devices—Ohio and New York City, 1996
Journal: JAMA (1997)

Fingerstick devices are widely used for capillary-blood sampling for glucose monitoring in patients with diabetes. In 1996, outbreaks of hepatitis B virus (HBV) infection occurred among patients with diabetes in an Ohio nursing home and in a New York City hospital. In response to these outbreaks, nursing-home and hospital personnel, state and local public health officials, and CDC conducted epidemiologic investigations. This report summarizes the investigations, which suggest that, in both outbreaks, HBV transmission was associated with use of spring-loaded fingerstick devices on multiple patients.
YOUR OWN HIPPOCRATIC TREE
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nanoheating technology.
Authors: Oliver Szasz, Nora Meggyeshazi, Gabor Andocs, Csaba Kovago
Journal: Journal of Clinical Oncology (2014)

e14016 Background: Heating by nanoparticles is a well-recognized method in hyperthermic oncology. However, the process has numerous complications by the administration of the particles, their targeting and sometimes their post-treatment processes. Our aim is to present selective nanoscopic heating method. Methods: The experimental setup was made in vivo, on HT29 human colorectal xenograft and C26 mouse colorectal allograft models in time-course investigations. We apply 13.56 MHz radiofrequency (RF) signal modulated by 1/f noise pattern action on membrane processes by enzymatic wheel energized by electric field [Westrehoff HV, et al., Proc. Natl. Acad. Sci. USA, 83:4734-4738 (1986)]. The modulated RF selectively targets the membrane rafts of malignant cells without harming the non-malignant neighborhood [Andocs G, et al. Electrom. Biol. Medicine, 28:148-165 (2009)]. Results were analyzed by various histomorphological and immunhistochemical analysis, using digital microscopy. Results: The majority of cell-destruction was apoptosis by massive TUNEL positivity. An up regulation of TRAILR2 (DR5), FAS and FADD was observed 8h post-treatment. AIF nuclear translocalisation was observed at 14-24h together with mitochondrial pore formation and cytochrome-C release, and DNA fragmentation developed at 24-48h post-treatment. The process showed clear damage associated molecular pattern (DAMP): calreticulin release at 4-8 h, elevation of HSP70 and HSP90 after 24h, and HMGB1 release at 48h. These processes are probably parts of the immunogenic cell-death (ICD) of the selected malignant cells. Conclusions: The modulated RF-current heats nanoscopically, targets the membrane rafts of malignant cells, induces apoptosis. DAMP forming was observable, which could be the base of the ICD process.