tbuckley/cabot-search huggingface dataset:
Practical Points in the Management of the Diseases of Children.
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE NETHERLANDS
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Erratum: Vol. 66, No. 22
Journal: MMWR Morbidity and Mortality Weekly Report (2017)

In the report "Japanese Encephalitis Surveillance and Immunization - Asia and Western Pacific Regions, 2016," on page 581, in the table "Characteristics of Japanese encephalitis (JE) surveillance in countries with JE virus transmission risk, 2016," and on page 582, in the table "Characteristics of Japanese encephalitis (JE) immunization programs in countries with JE virus transmission risk, 2016," Taiwan should have been indented beneath China. The corrected tables with added indents can be found at http://apps.who.int/iris/bitstream/10665/255639/1/WER9223.pdf.
Phase II screening study of a LHRH analogue, dexamethasone and somatostatin analogue versus LHRH analogue with dexamethasone in HRPC
Authors: M. Silva, F. E. Calais da Silva, F. Gonçalves, R. T. Oliver
Journal: Journal of Clinical Oncology (2008)

16082 Background: As far as prostatic cancer is concerned, we know that somatuline (SMS) blocks GH, PRL, tissular growth factors (TGF) and that it has a direct antiproliferative cellular growth effect. The simultaneous administration of depot forms of SMS and LHRH analogues induced the greatest decrease in tumor growth. Methods: A randomised Phase II trial was done in M0 (PSA ≥ 20 ng/ml) and M1 patients with hormone refractory prostate cancer to simultaneously screen decapeptyl and dexamethasone, both with and without SMS (120 mg every 4 weeks), with respect to the PSA response rate, time to PSA progression, duration of survival and toxicity. Results: 72 patients with a median PSA of 77 ng/ml were randomised, 35 to decapeptyl, dexamethasone, both with and without SMS (DDS) and 37 to decapeptyl and dexamethasone (DD). 18 of 33 (54%) patients on DDS and 13 of 32 on DD (43%) had a PSA response. The median time to PSA was 5.5 months in the SMS group and 1.9 months in the group without SMS. At 6 months, 45.7% were PSA progression free in the SMS group versus 35.1% in the goup without SMS. The median time to PSA progression in PSA responders was 10.6 months in the SMS group and 13.9 months in the group without somatuline. At 6 months, 73.7% of the PSA responders were progression free in the SMS group versus 81.3% in the group without SMS. 45 patients have died (62.5%), 22 (62.9%) in the SMS group and 23 (62.2%) in the group without SMS. 15 and 19 of the deaths respectively were due to prostate cancer. The median duration of survival is 1.65 years in the SMS group and was 1.48 years in the group without SMS. At 6 months, 85.7% were alive in the SMS group versus 78.1% in the group without SMS. At 12 months, 77.1% were alive in the SMS group versus 69.4% in the group without SMS. Conclusions: There is no evidence that SMS may have increased the incidence of side effects. The PSA response rate was slightly higher in the SMS group, 54% versus 43% and the median time to PSA progression in all patients appears to have been slightly longer in the SMS group. Fewer objective progressions were also observed in the SMS arm, 4 versus 12. These results suggest that SMS may add to the activity of decapeptyl and dexamethasone and thus have a role in the treatment of hormone refractory prostate cancer. No significant financial relationships to disclose.
Abstract 1260: Analysis of death receptor 5 and caspase-8 expression in primary and metastatic head and neck squamous cell carcinoma and their prognostic impact
Authors: Heath A. Elrod, Songqing Fan, Susan Muller, Georgia Z. Chen, Lin Pan, Mourad Tighiouart, Dong M. Shin, Fadlo R. Khuri, Shi-Yong Sun
Journal: Cancer Research (2010)

Abstract Death receptor 5 (DR5) and caspase-8 are major components in the extrinsic apoptotic pathway. The alterations of the expression of these proteins during the metastasis of head and neck squamous cell carcinoma (HNSCC) and their prognostic impact have not been reported. The present study analyzes the expression of DR5 and caspase-8 by immunohistochemistry (IHC) in primary and metastatic HNSCCs and their impact on patient survival. Tumor samples in this study included approximately 90 primary HNSCC with no evidence of metastasis and approximately 90 primary HNSCC and their matching lymph node metastasis. IHC analysis revealed a significant loss or downregulation of DR5 expression in primary tumors with metastasis [weight index (WI) = 221 ± 64.9 (mean ± SD), n = 92] and their matching lymph node metastasis (WI = 224 ± 71.6, n = 85) compared to primary tumors with no evidence of metastasis (WI = 250 ± 43.9, n = 94) (P &amp;lt; 0.01). A similar trend was also observed in caspase-8 expression although it is not statistically significant. Downregulation of caspase-8 and DR5 expression was significantly correlated with poorly differentiated tumors compared to moderately and well differentiated tumors (P &amp;lt; 0.05). Univariate analysis indicates that, in HNSCC with no metastasis, higher expression of caspase-8 significantly correlated with better disease-free survival and overall survival (P &amp;lt; 0.05 or 0.001) if mean value is used as a cutoff. However, in HNSCC with lymph node metastasis, higher caspase-8 expression significantly correlated with poorer disease-free survival and overall survival (&amp;lt; 0.05 or 0.01). Similar results were also generated when we combined both DR5 and caspase-8. Moreover, multivariable analysis indicates that in patients without lymph node metastasis, high caspase-8 is significantly associated with better survival after adjusting age and stage (P &amp;lt; 0.0001). Together, we suggest that both proteins may be involved in regulation of HNSCC metastasis. (G.C., D.M.S., F.R.K. and S-Y.S. are Georgia Cancer Coalition Distinguished Cancer Scholars. This study was supported by funds from the Georgia Cancer Coalition Distinguished Cancer Scholar and NIH Head and Neck SPORE P50 CA128613 awards) Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1260.
Medical Genetics
Authors: C. Thomas Caskey
Journal: JAMA (1990)

Medical genetics can be said to be the first subspecialty of molecular medicine. Rapid incorporation of recombinant DNA technology into the clinical diagnostics of genetic disease has been the modus operandi of the field. At the 1989 American Society of Human Genetics meeting, more than 60% of manuscripts were molecular descriptions of disease genes. Application of DNA-based diagnostics has been accelerated by development of the polymerase chain reaction. Yeast artificial chromosome vectors and other methods for cloning large DNA segments and data flow from the Human Genome Initiative will accelerate disease gene identifications far beyond the expectations of 1 or 2 years ago. In only about 100 of the more than 3000 known heritable diseases has the mutant gene been isolated.<sup>1</sup>We anticipate identification of all 50 000 to 100 000 human genes within 10 to 15 years. To accommodate the application of DNA technology for molecular medicine, we
The integrated use of accurate virological and serological HBV markers can help identifying HBsAg-negative/anti-HBC-positive patients at higher risk of HBV-reactivation and optimizing the duration of prophylaxis in oncohematological setting
Authors: Romina Salpini, Carlotta Cerva, Mohammad Alkhatib, Lorenzo Piermatteo, Arianna Battisti, Vincenzo Malagnino, Lavinia Fabeni, Maria Cantonetti, William Arcese, Francesca Ceccherini Silberstein, Carlo Federico Perno, Massimo Andreoni, Loredana Sarmati, Valentina Svicher
Journal: Journal of Hepatology (2020)
Cardiac size and left ventricular performance. Lack of correlation with silhouette measurement
Authors: P. D. Stein
Journal: JAMA (1974)

The validity of using the measurement of the cardiac silhouette as an objective guide for the evaluation of left ventricular performance was investigated in 75 patients with arteriographically demonstrated coronary heart disease. None of the measurements of the silhouette, when normal, reliably excluded poor left ventricular function. Even the most reliable dimensions of the cardiac silhouette, the frontal plane transverse diameter, oblique diameter, and cardiothoracic ratio, frequently were normal in individuals with moderate to severe impairment of ventricular function. The results of this study suggest that the size of the cardiac silhouette should be considered only secondarily for the purpose of clinically evaluating the functional state of the left ventricle. By implication, these results also suggest that a greater reliance should be placed on other clinical methods, including a carefully taken history and physical examination. (<i>JAMA</i>229:1614-1620, 1974)
A. B. C. of Swedish Gymnastics.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tonsillectomy in Patients with Coagulation Defects
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Treatment of oesophageal cancer
Authors: R A C Hughes
Journal: Journal of the Royal Society of Medicine (2002)

RSM, pp.38±42) is that the therapeutic effect of leeches is due not to the amount of blood ingested but to continued bleeding after their detachment.Their saliva contains the most potent natural anticoagulant known (hirudin) and a histamine-like vasodilator that promotes local bleeding, a local anaesthetic and hyaluronidase that enhances the spread of other salivary secretions into the bite wound 1 .Blood loss after prolonged use of leeches must be monitored.Leeches must also be prevented from `wandering' or attaching to normal or better perfused tissues.
American Heart Journal, St. Louis
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
"Improvement" in Untreated Psychiatric Patients
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Erratum
Journal: BMJ (1904)

WE have receivod the f,llowinDg appeal: Will you kindly allow us to appeal to the.benevolent readers of the BRITISH MEDICAL JOURNAL for immediate help on behalf of the widow and five children of a doctor -who has just-died-who.through illness, was for some years unable to support his family ?Four of the children are now dependent on the widow, and one.partiallyso.He was much respected in the country town in which, for x6 years, he practised, holding also Local Govern- ment appointments.The wife has been-and still is-struggling to provide for herself and -family, but financial support is absolutely necessary to render her efforts effective.The generosity of private friends has been severely taxed, and now there is no source of income whatever available.The delicate health of the widow and two of the children adds to the urgency of this appeal.
Substitution of drugs
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
N-Hydroxylation of Carcinogenic and Mutagenic Aromatic Amines
Authors: R. Kato, T. Kamataki, Y. Yamazoe
Journal: Environmental Health Perspectives (1983)

N-Hydroxylation and mutagenic activation of heterocyclic aromatic amines from protein pyrolysis products were studied in rat liver microsomes and nuclei, rat hepatocytes and various species of purified cytochrome P-450. These mutagenic amines include Trp-P-2 (3-amino-1-methyl-5H-pyrido[4,3-b]indole), Trp-P-1 (3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole), Glu-P-1 (2-amino-6-methyldipyrido-[1,2-a:3',2'-d]imidazole), Glu-P-2 (2-amino-dipyrido[1,2-a:3',2'-d]imidazole) and IQ (2-amino-3-methyl-3H-imidazo-[4,5-f]quinoline). The number of revertants of Salmonella typhimurium TA 98 was always correlated to the amount of each of the N-hydroxylated metabolites in various experimental conditions. The N-hydroxylated amines covalently bound to DNA directly or after being acylated with amino acids by amino-acyl-tRNA synthetase. Various species of cytochrome P-450 preparations showed markedly different activity in N-hydroxylation and mutagenic activation of Trp-P-2, Glu-P-1 and IQ. A high spin form of cytochrome P-450, isolated from the liver of PCB-treated rats, showed very high activity in N-hydroxylation of Trp-P-2, Glu-P-1 and 2-aminofluorene, although its activity was very low in benzo(a)pyrene hydroxylation. The present results indicate that different species of cytochrome P-450 are involved in the N-hydroxylation and mutagenic activation of aromatic amines.
Methods for Perfusing the Male Reproductive Tract: Models for Studying Drug and Hormone Metabolism
Authors: C. W. Bardin, H. W. G. Baker, L. S. Jefferson, R. J. Santen
Journal: Environmental Health Perspectives (1978)

Methods for perfusing rat testis and accessory sex organs in situ by recirculating artificial medium to the hemicorpus preparation are described. The advantages and limitations of this system for studying the male reproductive tract were examined. The preparation was then used to study the uptake of androgens into the nuclei of caput epididymis, ventral prostate, seminal vesicle and testis. The accumulation of dihydrotestosterone and accessory sex organ nuclei was saturable and inhibited by perfusion of excess testosterone or cyproterone acetate. By contrast, testosterone was the major nuclear androgen in the testis of mature hypophysectomized preparations perfused with testosterone. In all parts of the reproductive tract, 3H-nuclear androgens were associated with 3S, salt-extractable macromolecules within the properties of androgen receptors. The hemicorpus preparation was extensively compared with two techniques (selective and isolated) for perfusing the testis directly. Of these two procedures, the isolated method was superior when only the testes were studied. However, the hemicorpus preparation offers the advantage of studying testes along with the remainder of the male reproductive tract. A variety of observations suggest that these perfusion procedures will be useful for the study of drug as well as hormone metabolism and mechanism of action.
ABSTRACTS
Authors: Ernst Jaff, # {233}, Klaus Betke, Arthur Germany, T Bothwell, T Brittingham, J Chatterjea, F Cleton, Pietro Denicola, Ludvik Donner, Katsuhiro Fukutake, R Neuwirtov, # {225}, A Vdlek, R Tomasek, P Bronlik, H Em- Oglobinuria Miura, A Shibata, S Takase, S Onodera, A Suzuki, S Sakamoto, C Suzuki, V Halitskrj, E Schwalh, B Krumholz, D Gromisch, P Schwartz, J Wolff, B Grossman, K Paya, G Perona, L Vettore, G Ghiotio, S Cortesi, G Dc, B Sayed, S Ansin, Saemia Swarup, S Ghosh, M Dutta, S Swamp, A Basis
Journal: Blood (1967)