tbuckley/cabot-search huggingface dataset:
Knee osteoarthritis. Efficacy of a new method of contrast-enhanced musculoskeletal ultrasonography in detection of synovitis in patients with knee osteoarthritis in comparison with magnetic resonance imaging
Authors: I H Song, G R Burmester, M Backhaus, C E Althoff, K G Hermann, A K Scheel, C Werner, T Knetsch, M Schoenharting
Journal: Annals of the Rheumatic Diseases (2008)

<h3>Objective:</h3> To develop a new method of digital synovial vascularisation quantification by using contrast-enhanced musculoskeletal ultrasonography (MUS) in detecting synovitis in patients with knee osteoarthritis (OA) compared with healthy subjects and MRI. <h3>Methods:</h3> Evaluation of 41 patients with painful knee OA and 6 healthy subjects. The severity of knee pain was evaluated. All patients and all 6 healthy subjects underwent contrast medium-enhanced (CE)-MUS with SonoVue®, and 36 patients additionally underwent CE-MRI with Magnevist. Joint effusion, synovial thickening and pain were assessed and compared with B-mode and Power Doppler sonography (PDS) as well as contrast medium enhancement. <h3>Results:</h3> Pain evaluated by the visual analogue scale (VAS) hardly correlated with other markers of disease activity measured by ultrasound (US) in B-mode or MRI. US of the superior recess revealed an effusion or synovial thickening in 58%. PDS findings were positive in 63%, and CE-MUS in the superior knee recess was positive in 95%. MRI showed effusion in the superior recess in 61% and showed positive findings in 82% when using contrast medium. The kappa value was 0.48 between US and MRI with regard to the effusion in the superior recess, and 0.53 between PD signal in the superior recess and effusion in the superior recess by US. Using MRI as the reference standard, there was a sensitivity of 72% for assessing effusion in the superior recess and 81% for assessing effusion in the lateral recess. <h3>Conclusion:</h3> Assessment of disease activity (synovitis) in knee OA by VAS is not sufficient. US PDS was more sensitive than B-mode, and CE-MUS was more sensitive than PDS and CE-MRI in detecting synovitis in patients with painful knee OA. Also, CE-MRI was more sensitive in detecting inflammatory changes in the superior recess than without contrast medium. Using CE-MUS and performing time/intensity analysis has shown to be a good model for evaluation of an inflammatory process in the setting of knee OA in the superior recess.
Acetozone Solutions.
Authors: Louis S. De Forest
Journal: JAMA (1905)

New Haven, Conn., Dec. 3, 1905. <h3>To the Editor:</h3> —I am anxious to learn if any one else has had any experience in the use of acetozone solutions for injection into the spinal canal after lumbar puncture in cerebrospinal meningitis. I have used it recently with apparently good results in two severe and protracted cases. In both these cases puncture had already been required to relieve urgent pressure symptoms, but, while successful in this respect, the procedure had been without effect on the temperature. After the acetozone injections this remained nearly normal. A weak solution (5 grains to quart) was used, the patients being aged 7 and 4 respectively. In the first case 30 c.c. of fluid were withdrawn and 15 c.c. of the acetozone solution injected; in the second case 35 c.c. were withdrawn and 15 c.c. injected. In the acute fulminating cases, in which death takes place before
THE DISINFECTION OF PAPER MONEY.
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PD-L1 and p16 expression in penile squamous cell carcinoma from an endemic region.
Authors: Mateus Webber De Bacco, Andre P. Fay, Gustavo Carvalhal, Josenel Copetti, Bradley Alexander McGregor, Guru Sonpavde, Mario Wagner
Journal: Journal of Clinical Oncology (2019)

515 Background: Penile squamous cell carcinoma (PSCC) is a rare malignancy with limited treatment option in advanced stages. Brazil has one of the highest incidences of PSCC in the world, and different biology has been postulated across distinct populations. We evaluate PD-L1 and p16 expressionand its association with clinical outcomes in PSCC patients from an endemic region. Methods: Formalin-fixed paraffin-embedded (FFPE) specimens were obtained from 35 patients with PSSC. PD-L1 and p16 expression were evaluated by immunohistochemistry. PD-L1 tumor positivity (PD-L1+) was defined as ≥1% tumor cell membrane staining using ZR3 antibody. Any tumor cell membrane staining of p16 was considered positive (p16+). Baseline characteristics including tumor size, stage, grade, subtype, and survival data were collected. Comparisons between PD-L1 and/or p16 expression and clinicopathological features were evaluated using fisher exact testor wilcoxon rank sum tests. Cox model tested the association of PD-L1 and/or p16 expression and 5-year-survival. Results: Clinical features were summarized in table1 according to PD-L1 expression. PD-L1 positivity was significantly associated with larger tumor size ( p=0.027), and p16 expression, a surrogate for HPV infection ( p=0.002). There was a non-statistically significant trend to a shorter 5-year-survival for PD-L1+/p16+ vs. PD-L1-/p16- patients (30.8% vs. 60.6% HR: 2.27 95% CI - 0.61-8.42 p=0.22). Conclusions: PD-L1 expression appears to be associated with p16 expression, larger tumors, higher proliferative rate and worse clinical outcomes in patients with PSCC. provide additional rationale for PD1/PD-L1 inhibitors alone or in combination with chemotherapy foradvanced PSCC in endemic regions. Clinical features. [Table: see text]
<i>Circulation</i> Editors' Picks: Most Read Articles in Cardiovascular Interventions
Journal: Circulation (2011)

The following articles are being highlighted as part of Circulation's Topic Review series. This series will summarize the most important manuscripts, as selected by the editors, published in Circulation and the Circulation subspecialty journals. The studies included in this article represent the most read manuscripts published on the topic of cardiovascular interventions in 2009 and 2010.
Allergy abstracts
Authors: Murray Albert Brooklyn, N Eugene, Walzer Bridgeport, Neil Goldman Ossining, N Sheldon Berger Freehold, Harold Friedman, Clet~eland Ohio, Monroe Srmfi, Cm-M Siegel Brooklyn, N Eloise, Kailin Sequim, Wush Stein, Spring Valley, M Britton
Journal: Journal of Allergy and Clinical Immunology (1977)
PRACTICAL NOTES.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE ASSOCIATION OF SOUTHERN MEDICAL COLLEGES.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Silymarin retards collagen accumulation in early and advanced biliary fibrosis secondary to complete bile duct obliteration in rats
Authors: G Boigk
Journal: Hepatology (1997)

Silymarin (SIL), a standardized plant extract containing about 60% polyphenole silibinin, is used as a hepatoprotective agent. Its antifibrotic potential in chronic liver diseases has not been explored. Therefore, we applied SIL to adult Wistar rats that were subjected to complete bile duct occlusion (BDO) by injection of sodium amidotrizoate (Ethibloc). This treatment induces progressive portal fibrosis without significant inflammation. Rats with sham-operation that received SIL at 50 mg/kg/d (n = 10) and rats with BDO alone (n = 20) served as controls, whereas groups of 20 animals were fed SIL at a dose of 25 and 50 mg/kg/d during weeks 1 through 6 or doses of 50 mg/kg/d during weeks 4 through 6 of BDO. Animals were sacrificed after 6 weeks for determination of blood chemistries, total and relative liver collagen (as hydroxyproline [HYP]), and the serum aminoterminal propeptide of procollagen type III (PIIINP). BDO in untreated rats caused an almost ninefold increase in total liver collagen (16.1 ± 3.1 vs. 1.8 ± 0.4 mg HYP, P < .001). SIL at 50 mg/kg/d reduced total HYP by 30% to 35%, either when given from week 1 through 6 or from week 4 through 6 after BDO (10.6 ± 2.7 and 10.2 ± 3.9 mg HYP, both P < .01 vs. BDO alone), whereas 25 mg/kg/d were ineffective. Because SIL at 50 mg/kg/d also reduced the collagen content per gram of liver tissue, it acted as a true antifibrotic agent. The single value of PIIINP at killing paralleled the antifibrotic activity of SIL with 11.6 ± 3.8 and 9.9 ± 3.7 vs. 15.3 ± 5.2 microg/L in both high-dose groups (P < .05 and P < .01, respectively, vs. rats with BDO alone). Except for a decreased alkaline phosphatase and a lower histological fibrosis score in the groups that received SIL, clinical-chemical parameters were not different among all groups with BDO. We therefore conclude that 1) BDO with Ethibloc is a suitable model to test for pure antifibrotic drugs because it induces progressive rat secondary biliary fibrosis without major inflammation; 2) oral SIL can ameliorate hepatic collagen accumulation even in advanced (biliary) fibrosis; and 3) PIIINP appears to be a suitable serum marker to monitor the inhibition of hepatic fibrogenesis in this model of biliary fibrosis.
POLITICAL INFLUENCE OF PHYSICIANS.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Rheumatology
Authors: D. J. McCarty
Journal: JAMA (1993)

The sporadic reports of connective tissue disorders in women who have had breast augmentation mammaplasties using silicone implants led the Food and Drug Administration (FDA) to withdraw approval for the procedure, except for breast reconstruction after cancer surgery.<sup>1</sup>Even in this situation, implants are now available only if the patient agrees to become a subject in a clinical trial. Understandably, the FDA decision has elicited reactions ranging from dismay to panic in the more than 2 million American women who have had silicone implants. Plastic surgeons and lawyers have been contacted in large numbers. Polymeric silicone substances have been and are being used for penile implants and for arthroplasty of the wrist and metacarpophalangeal and metatarsophalangeal joints. The safety of these devices has also been questioned, but the FDA has not yet withdrawn them from the marketplace. Reports of single cases and small series of patients who developed rheumatic
AUTHOR'S REPLY
Authors: A M W J Schols
Journal: Thorax (1992)

Body composition and exercise per- formance in patients with chronic ob- structive pulmonary disease (COPD)The original article ofDr A M W J Schols and others in the October issue of Thorax' shows that exercise performance, as indicated by the distance walked in 12 minutes, is related to the fat free mass of the patient.Fat free mass was taken to be an indicator of muscle mass, but the investigators found that arm muscle size was not well related to other measures of muscle mass.Several possible reasons for the relation- ship, two of which were related to respiratory muscle performance, were considered.There are, however, two other obvious possibilities.Firstly, muscle loss may well be from the lower limbs.If this were so, then exercise capacity could be reduced because of the smaller capacity for this type of exercise, irrespective of respiratory muscle function.Secondly, the patients who performed badly might take little regular exercise, or indeed may be limited by their symptoms in their exercise.Such patients would display lower limb muscle wasting.Consequently, performance may be related to muscle mass (particularly in the legs) by loss of activity.In the clinical evaluation of patients who are housebound with severe lung or cardiac dis- ease wasting of the quadriceps femoris and calf muscles is often a striking feature.Dr Schols and his colleagues suggest that a compromised nutritional state may con- tribute to impaired performance, and that muscle mass determines exercise performance.Unwary readers may be led to conclude that patients do badly because of malnutrition, or even that improved nutrition might be beneficial.This is not necessarily so.Correlation does not indicate cause and effect: even if there is such a relationship, which is cause and which is effect may not be self evident.
ANCIENT PROBLEMS OF PHARMACY AND THEIR WARNING
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Respiratory Failure
Authors: Harry B. Greenberg
Journal: JAMA (1969)

<b>The Lungs in Systemic Diseases,</b>by Eli H. Rubin and Stanley S. Siegelman, 312 pp, 149 illus, $20.75, Springfield, Ill: Charles C Thomas, Publisher, 1969. To sustain the patient whose respiration is failing, the physician often has to choose hurriedly from an array of oxygen masks, tents, and complex machines. The incisive book by Sykes, McNichol, and Campbell provides him with an interesting and highly readable guide. Its diagrams, drawings, charts, and photographs make reference easy. Though the equipment described is British, the American counterparts are readily identified. In clear, precise descriptions of physiologic changes, the authors emphasize information obtained from tests that are performed quickly, without unduly disturbing the patient. After commenting on the fallibility of clinical judgment, they stress the use of blood-gas analyses to assess the patient's respiratory insufficiency and guide his treatment. They regard measurement of the patient's arterial carbon dioxide tension as fundamental, and also
The consequences of treatment and disease in patients with primary CNS non-Hodgkin's lymphoma: Cognitive function and performance status
Authors: Brian P. O'Neill, Chiao-Hua Wang, Judith R. O'Fallon, Joseph P. Colgan, John D. Earle, Robert L. Krigel, Loren D. Brown, William J. McGinnis
Journal: Neuro-Oncology (1999)

Neuro-OncologyPer protocol, patients with primary CNS non-Hodgkin's lymphoma in an intergroup phase II trial conducted by the North Central Cancer Treatment Group and the Eastern Cooperative Oncology Group had their cognitive functions measured using the Folstein and Folstein Mini-Mental Status Examination (MMSE) and their physical functions measured using the Eastern Cooperative Oncology Group Performance Score (PS) at study entry, at each treatment evaluation, and at quarterly intervals thereafter until disease progression or death.Of the 53 eligible participants who began therapy, 46 (87%) had baseline MMSE scores recorded, 36 (68%) had at least one follow-up MMSE, and 32 (60%) had both, while 52 (98%) had baseline PS, 49 (92%) had at least one follow-up PS, and 48 (91%) had both.Patterns of MMSE and PS values over time were studied in each individual, in the group as a whole, in the 20 patients who completed the study regimen, in the 23 who survived more than a year, and in patients who were classi ed as nonprogressors at each key evaluation.For each patient, all recorded values were plotted versus time, with dates of disease progression and death included, to look for signs of decline in cognitive or physical function preceding adverse events.Long-term declines in scores of both cognitive and physical function were observed in many treated patients with primary CNS non-Hodgkin's lymphoma.Nearly all patients who were alive more than 52 weeks after study entry had a demonstrable decline in cognitive and physical functionality.Such declines may occur before disease progression is documented; they may also occur in some patients who have long-term follow-up without evidence of disease progression.Declining MMSE and PS was a poor predictor of disease progression.There was no association of PS and toxicity.The data from this study demonstrated the considerable dif culties we encountered conducting an ancillary study such as this within a multicenter clinical trial.Firstly, the test instruments written into the protocol were unable to tell if the declines seen were due to disease, treatment, co-morbidity, or other factors.Secondly, the missing data created dif culties in interpreting outcome.
Fiabilité et précision d'un nouveau système de classification utilisant la cholangioscopie per-orale pour le diagnostic des lésions des voies biliaires
Journal: Endoscopy (2018)

Les cholangioscopes de nouvelle génération apparaissent comme intéressants dans le diagnostic de sténose d’origine indéterminée pour distinguer les lésions biliaires néoplasiques de celles non néoplasiques. Les critères macroscopiques actuellement utilisés restent imparfaits et de faible concordance inter-observateur (45 %). Robles-Medranda C et al ont donc développés dans cette étude une classification cholangioscopique à partir de critères macroscopiques connus, comme la présence de néovaisseaux irréguliers, tortueux, et dilatés, des saignements biliaires spontanés, une irrégularité de surface, et la présence d’une masse sténosante intracanalaire.
Billions in Compensation for Toxic Oil Poisoning Victims
Authors: X. Bosch
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal