tbuckley/cabot-search huggingface dataset:
The semi-individual study in air pollution epidemiology: a valid design as compared to ecologic studies
Authors: N Künzli, I B Tager
Journal: Environmental Health Perspectives (1997)

The assessment of long-term efects of air pollution in humans relies on epidemiologic studies.A widely used design consists of cros-sectional or cohort studies in which ecologic a n of exposure, based on a fixed-site ambient monitor, is employed.Alhough health outcome'an usu- ally a large number of covarates are measured in individuals, these studies are ofien called ecolog- ical.We will inrdu the term semi-individual design for these studies.We review the major properties and limittiowithregad xto caus inrence of tr ecologic stuies, in Which out- come, exposure, and c iatesaavailable on an egate level only.Mislassification problems and issues related to unding ant model spedflcatio n truly ecologic studies limit etiologic inference to individuals.In contrast, the semi-individual study shares its methodological and inferential propeties th typical individual-level study designs.The major caveat relates to the case where too few study area, eg o or three, are used, which render conl ofaggregate kvel confounding imposble.The issue of exposure sifion is of genera concern in epidemi- ology and not an exdusive problem of the semi-individual design.In a multicenter setting, the
The Element of Surprise
Authors: Mounica Vallurupalli, Anand Vaidya, Michael Foote, Nina Jain, Aric Parnes
Journal: New England Journal of Medicine (2019)

A 64-year-old woman presented to the emergency department with fatigue and shortness of breath when walking short distances or climbing stairs. She described severe fatigue with minimal physical activity that had progressively worsening over several months. She also reported having nausea and loose stools during this time and had lost approximately 5.4 kg since the onset of symptoms. . . .
Postinfluenzal depression
Authors: R Haig
Journal: BMJ (1976)

and his Addison's disease might have been induced therefore by sarcoidosis rather than by "idiopathic" adrenal failure.If so, his wife could have contracted one or other of these diseases herself subclinically.The prolonged cellular immunity generated by sarcoidosis might have cven triggered off her mammary carcinoma.! Was raised immunity then responsible for the other malignancies in this family?A few tuberculous parents have had children who later developed sarcoidosis.The son in this family was found much later to have the coeliac syndrome.Was this also caused by the sarcoid agent?'The answers to these questions are still unknown because not enough facts are yet available.But it is unlikely in the meantime that natural selection will eliminate the sarcoid agent.
Erratum
Journal: BMJ (1901)

that even small quantities have au iihliibitory actOio on digestion, par- ticularly on the rennet curdling of milk.According to the receut ob- servations of Tunniclifte and Roseniheim (Journtat of Hygiese, JulY, x901, p. 321), the admniuiistration of formic aldelhyde up to X to 5,ooo in 1)i1k or I to s,ooo in total food and drink (formalin Is a 40 per cent.solution of formic aldelhyde, and about 2 drops of this are stated to be added to eaclh fluid ounce of milk) produces no appreciable iiutluence on the general health or well-being oflealltly children.Their results, however, sug-
Induced pluripotent stem cell–derived human platelets: one step closer to the clinic
Authors: Christos Gekas, Thomas Graf
Journal: The Journal of Experimental Medicine (2010)

The era of induced pluripotent stem (iPS) cells carries with it the promise of virtually unlimited sources of autologous cells for regenerative medicine. However, efficiently differentiating iPS cells into fully functional mature cell types remains challenging. A new study reporting the formation of fully functional platelets from human iPS (hiPS) cells improves upon recent efforts to generate this enucleated cell type, which remains in high demand for therapeutic transfusions. Notably, their lack of nucleus renders platelets unable to retain the pluripotent or tumorigenic properties of iPS cells.
HEREDITY AND PSORIASIS
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Erratum: Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy
Authors: Sam E Day, Mikko I Kettunen, Ferdia A Gallagher, De-En Hu, Mathilde Lerche, Jan Wolber, Klaes Golman, Jan Henrik Ardenkjaer-Larsen, Kevin M Brindle
Journal: Nature Medicine (2007)
HEREDITARY AMYLOIDOSIS?
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The incremental prognostic value of chronotropic i the prediction of cardiac death in patients undergoing myocardial perfusion SPECT imaging Babak Azarbal, Howard C. Lewin, Enrique F. Schisterman, Sean W. Hayes, John D. Friedman, Ishac Cohen, Xing-Ping Kang, Daniel S. Berman. Cedars-Sinai Medical Center, Los Angeles, CA
Journal: Journal of the American College of Cardiology (2001)
2018 年英国皮肤科医师协会有关在无基础皮肤病的成年患者中检查和管理全身瘙痒的指南
Authors: G.W.M. Millington, A. Collins, C.R. Lovell, T.A. Leslie, A.S.W. Yong, J.D. Morgan, T. Ajithkumar, M.J. Andrews, S.M. Rushbook, R.R. Coelho, S.J. Catten, K.Y.C. Lee, A.M. Skellett, A.G. Affleck, L.S. Exton, M.F. Mohd Mustapa, N.J. Levell
Journal: British Journal of Dermatology (2018)

瘙痒(或发痒)是许多皮肤病、全身性疾病以及心理障碍的一种常见症状,非常令人苦恼。发痒可能是最常见的皮肤病主要症状。8% 至 9% 的患者在两周时间内会有显著瘙痒。该指南关注有瘙痒但无皮疹的情况,而不是发痒性皮疹。此外,该指南并未涉及儿童瘙痒以及妊娠期瘙痒,也未详述瘙痒原因。研究组成员大多是来自英国多家医院的皮肤科医生(皮肤科专家),当然也包括其他医院的医生、护士以及全科医生 (GP)。血液紊乱、缺铁或铁过量、肾脏问题、肝脏问题、癌症、感染、药物治疗、行为因素、皮肤干燥或任意综合症状以及衰老等都可能是瘙痒的基础病因。皮肤瘙痒但无皮疹的病例很多,占 20% 至 30%。皮肤瘙痒但无明显基础病因或皮疹的个体数量仍占少数。应始终探讨基础的致病条件,因为只有针对任何基础疾病对症治疗,才能最有效地管理非皮疹性瘙痒。即使无法治疗基础病因,也要针对具体情况来进行瘙痒管理。而对于病因未知的真正瘙痒的管理又有所不同。
New Solution for Preserving Red Blood Cells
Authors: C. Marwick
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Immunoglobulins in mink ranchers associated with Aleutian disease
Authors: R. C. Williams
Journal: JAMA (1965)

Aleutian disease (AD) is characterized in mink by marked hypergammaglobulinemia; plasma-cell infiltration of liver, kidneys, and lymph nodes; and terminal bleeding tendency. A survey of fur-farm associates was prompted by a report of a fatal illness, similar in some clinical and pathological aspects to AD, in a mink rancher. Particular attention was directed toward quantitative measurement of immunoglobulins IgG, IgA, and IgM as an index of possible subclinical AD infection. No distinct immunoglobulin abnormalities among the fur-farm associates were uncovered when compared to controls matched for age and sex. Since the presumed infectious agent has not yet been isolated or characterized, direct serologic testing for specific AD antibody among mink handlers cannot yet be evaluated.
Medicolegal
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Colovesical Fistula
Authors: Henry W. Murray
Journal: JAMA (1979)

<h3>To the Editor.—</h3> Fecaluria results from communication between the bowel and bladder and is a pathognomonic sign of colovesical fistula.<sup>1</sup>These fistulas are most often associated with either sigmoid diverticulitis or carcinoma of the lower bowel or bladder. Recently, what appeared to be a routine urinary tract infection developed in one of our elderly female patients.<i>Escherichia coli</i>, sensitive to all antibiotics tested, was cultured from the urine. Despite seven days of intravenous ampicillin treatment, cultures remained positive. Parenteral gentamicin sulfate was substituted for an additional week without success. Several days later, the patient's urine, which had previously been clear, abruptly turned dark brown and contained particulate matter (Figure). A colovesical fistula was then suspected as the cause of the recalcitrant urinary tract infection. Communication between the bowel and bladder was subsequently verified at cystoscopy. We think this photograph is a visually impressive and instructive example of this diagnostic
OCULAR DEFECTS AND HEADACHE.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Noncardiac causes of pulmonary edema
Authors: J. F. Phillips
Journal: JAMA (1975)

<h3>Common1</h3> Agonal Aspiration (eg, Mendelsohn syndrome) Cerebral (stroke, head trauma, epilepsy) Drug hypersensitivity, allergy, or poisoning Fluid overload; overtransfusion Glomerulonephritis (acute) Narcotics (heroin and others) Oxygen toxicity (shock lung) Pulmonary embolism or infarct Uremia <h3>Uncommon</h3> Hanging; suffocation High altitude Hypoproteinemia Inhalation of noxious gas Intravascular coagulation defect Liver disease [Lymphangiectasia] Malaria Mediastinal tumor with venous or lymphatic obstruction Near-drowning Pneumothorax Pregnancy Pulmonary veno-occlusive disease Radiation therapy Shock Thoracic trauma Transfusion reaction <h3>Diagnosis</h3> Pulmonary edema secondary to heroin overdose. <h3>Comment</h3> The patient was treated with endotracheal positive pressure ventilation, and sodium bicarbonate was administered to correct acidosis. The patient responded rapidly to therapy, and a roentgenogram the following day showed complete resolution of the bilateral alveolar infiltrates. Cardiovascular disease is certainly the
Functional Toxicology: A New Approach to Detect Biologically Active Xenobiotics
Authors: John A. McLachlan
Journal: Environmental Health Perspectives (1993)

The pervasiveness of chemicals in the environment with estrogenic activity and other biological functions recommends the development of new approaches to monitor and study them. Chemicals can be screened for activity in vitro using a panel of human or animal cells that have been transfected with a specific receptor and reporter gene; for example, the estrogen receptor. By using a variety of different receptors, the screening of xenobiotics for biological functions can be broad. Chemicals could then be classified by their function in vitro which, in some cases, may be a useful guide for toxicological studies.
Abstract not submitted for online publication
Journal: Genome biology (2011)

Deep exome resequencing is a powerful approach for delineating patterns of protein-coding variation among genes, pathways, individuals and populations.We analyzed exome data from 2,440 individuals of European and African ancestry as part of the National Heart, Lung, and Blood Institute's Exome Project, the aim of which is to discover novel genes and mechanisms that contribute to heart, lung and blood disorders.Each exome was sequenced to a mean coverage of 116×, allowing detailed inferences about the population genomic patterns of both common variation and rare coding variation.We identifi ed more than 500,000 single nucleotide variations, the majority of which were novel and rare (76% of variants had a minor allele frequency of less than 0.1%), refl ecting the recent dramatic increase in the size of the human population.The unprecedented magnitude of this dataset allowed us to rigorously characterize the large variation in nucleotide diversity among genes (ranging from 0 to 1.32%), as well as the role of positive and purifying selection in shaping patterns of proteincoding variation and the diff erential signatures of population structure from rare and common variation.This dataset provides a framework for personal genomics and is an important resource that will allow inferences of broad importance to human evolution and health.
Treatment of Thyroid Cancer
Authors: Vijay M. Varma
Journal: JAMA (1970)

A total of 263 patients with histopathologically proved, well-differentiated papillary and follicular thyroid carcinoma were treated with sodium iodide I 131 after surgery. A 100% follow-up was achieved with a mean of 6.3 years, and an observation period of 0 to 20 years. The death rate in these patients was compared with the death rate in 50 patients with papillary and follicular carcinoma of the thyroid treated surgically before introduction of sodium iodide I 131 (control group), and followed for a mean of 6.7 years (0 to 20 years). These groups were matched in sex, but not in age distribution. In patients 40 years of age and older, the group treated with sodium iodide 1131 had a significantly lower death rate than the surgery-only group (P&lt;0.005). There was no significant difference in death rate between patients treated with sodium iodide 1131 and control patients 39 years of age and under.
A Physiologically Based Pharmacokinetic Model for 2,4-Toluenediamine Leached from Polyurethane Foam-Covered Breast Implants
Authors: Hoan-My Do Luu, Joseph C. Hutter, Harry F. Bushar
Journal: Environmental Health Perspectives (1998)

Physiologically based pharmacokinetic (PBPK) modeling was used to assess the low-dose exposure of patients to the carcinogen 2, 4-toluenediamine (2,4-TDA) released from the degradation of the polyester urethane foam (PU) used in Meme silicone breast implants. The tissues are represented as five compartments: liver, kidney, gastrointestinal tract, slowly perfused tissues (e.g., fat), and richly perfused tissues (e.g., muscle). The PBPK model was fitted to the plasma and urine concentrations of 2,4-TDA and its metabolite 4-AAT (4-N-acetyl-2-amino toluene) in rats given low doses of 2, 4-TDA intravenously and subcutaneously. The rat model was extrapolated to simulate oral and implant routes in rats. After adjusting for human physiological parameters, the model was then used to predict the bioavailability of 2,4-TDA released from a typical 4.87-g polyester urethane foam implant found in a patient who weighed 58 kg with the Meme and had the breast implant for 10 years. A quantitative risk assessment for 2,4-TDA was performed and the polyester urethane foam did present an unreasonable risk to health for the patient.
Outcome Of Patients With Abnl(17p) Acute Myeloid Leukemia After Allogeneic Hematopoietic Stem Cell Transplantation
Authors: Jan Moritz Middeke, Min Fang, Jan Cornelissen, Frederick R. Appelbaum, Brigitte Mohr, Michael Stadler, Miguel Sanz, Herrad Baurmann, Gesine Bug, Kerstin Schäfer-Eckart, Ute Hegenbart, Tilmann Bochtler, Friedrich Stölzel, Roland B. Walter, Gerhard Ehninger, Martin Bornhäuser, Bob Löwenberg, Johannes Schetelig
Journal: Blood (2013)
Update in Preventive Medicine
Authors: Laurence H. Beck
Journal: Annals of Internal Medicine (2001)

Updates from the Annual Session16 January 2001Update in Preventive MedicineLaurence H. Beck, MDLaurence H. Beck, MDFrom Cleveland Clinic Florida, Fort Lauderdale, Florida.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-134-2-200101160-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail To select the published articles that could most influence daily clinical practice, I reviewed all the major general medical journals and searched the MEDLINE database. I used an informal system for scoring the articles, focusing on their clinical relevance, scientific validity, and generalizability. Particular care was taken to choose research that was based on rigorous methods and incorporated appropriate blinding when necessary. Articles in two categories—influenza and modifications in diet and behavior—are in the realm of primary prevention, whereas work in osteoporosis and cardiovascular disease largely entails secondary preventive measures.Preventing Influenza Virus InfectionInfluenza remains a major source of ... Author, Article, and Disclosure InformationAffiliations: From Cleveland Clinic Florida, Fort Lauderdale, Florida.Corresponding Author: Laurence H. Beck, MD, Department of Internal Medicine, Cleveland Clinic Florida, 2900 West Cypress Creek Road, Fort Lauderdale, FL 33309. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 16 January 2001Volume 134, Issue 2Page: 128-135KeywordsCholesterolCoronary heart diseaseDrugsExerciseHigh density lipoproteinHypertensionRelative riskStrokeVaccinesWalking ePublished: 16 January 2001 Issue Published: 16 January 2001 CopyrightCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Surgery or Radiotherapy for Tonsil Cancer?
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The tympanic membrane. A source of the cough reflex
Authors: A. P. Wolff
Journal: JAMA (1973)

A cough can be caused by a hair lying against the tympanic membrane. To the best of our knowledge, this is documented for the first time by our report of three patients with chronic cough who experienced relief after a hair was removed from the ear drum. The explanation for this observation is based on a protective reflex mediated through afferent vagal nerve fibers.