tbuckley/cabot-search huggingface dataset:
Infantile agammaglobulinemia and immediate hypersensitivity to penicillin G
Authors: M. Ganier
Journal: JAMA (1977)

A case of X-linked infantile agammaglobulinemia with preserved synthesis of IgE and resultant normal serum levels of IgE is described. The patient had manifestations of atopy and an anaphylactic reaction following the administration of penicillin G. Because he had multiple respiratory tract infections with Gram-positive organisms and did not respond adequately to prophylactic γ-globulin administration, penicillin therapy was deemed desirable. Therefore, after successful desensitization, therapy with prophylactic ampicillin was started with a resultant decrease in both number and severity of infections. (<i>JAMA</i>237:1852-1853, 1977)
The clinical recognition of tinea capitis from Trichophyton tonsurans
Authors: A. H. Rudolph
Journal: JAMA (1979)

A change in the preponderant etiologic agent of tinea capitis in the United States has been occurring during the last 20 to 30 years. Before the 1950s, the<i>Microsporum</i>sp,<i>M audouinii</i>and<i>M canis</i>, were the organisms most commonly isolated in patients with tinea capitis. In the 1950s,<i>Trichophyton tonsurans</i>was introduced into the southern and southwestern states<sup>1,2</sup>from Puerto Rico and Mexico, where epidemics of tinea capitis from this organism previously had occurred. In the early 1960s, the problem of scalp infections caused by<i>T tonsurans</i>also was reported in urban areas in the Midwest and East.<sup>3</sup>In the 1970s, as Prevost reports (p 1765),<i>T tonsurans</i>is now the preponderant organism causing tinea capitis in Charleston, SC, a change also reported in other locations.<sup>4,5</sup> The emergence of<i>T tonsurans</i>as the preponderant cause of tinea capitis is important, for scalp infections caused by this
Thump-Version
Authors: Bernard Lown, Jack Taylor
Journal: New England Journal of Medicine (1970)

Increasingly, cardiologic jargon is encroaching on gynecologic nomenclature. Terminology now includes reference to various forms of version ranging from electroversion to cardioversion and now thump-version. This latest measure dispenses with gadgets and uses immediately available mechanical energy to terminate life-threatening arrhythmia. Effectiveness of the maneuver is due to conversion of the mechanical input into an appropriate electrical pulse.Mechanoelectrical transduction plays an integral part in biologic homeostasis. Muscle-stretch spindles, the vestibular organ and baroreceptors in the great vessels depend on this mechanism to form complex feedback loops for sustaining regulation. The basis for transduction of mechanical energy into propagated electrical . . .
Primary Sclerosing Cholangitis
Authors: Maureen Martin
Journal: Annual Review of Medicine (1993)

Primary sclerosing cholangitis (PSC) is an inflammatory disease of unknown etiology. It affects the biliary system and is characterized by fibrosis and progressive obliteration of extrahepatic and intrahepatic bile ducts. Its frequent coexistence with antibody-mediated diseases, certain human leukocyte antigens, and altered lymphocyte mechanisms suggests a strong autoimmune and genetic etiology. Other conditions such as recurrent cholangitis, acquired immunodeficiency syndrome, previous bile duct surgery, bile duct anomalies, or biliary stone disease may result in similar clinical patterns and radiologic profiles. PSC can be asymptomatic and slowly progressive over years, or it may develop rapidly with an inexorable progression to cirrhosis and portal hypertension. Clinical and biochemical abnormalities may suggest PSC, but it is the characteristic radiological pattern that secures the diagnosis. Once viewed as a rare entity, the widespread use of radiological and endoscopic methods have increased physician awareness. There is no successful medical treatment for PSC. While traditional surgical approaches have been directed at the relief of cholangitis and biliary obstruction, liver transplantation has emerged as definitive therapy for patients with PSC complicated by cirrhosis or recurrent bouts of cholangitis.
Professor Karl Braun's Operative Methods in Laparotomy.
Journal: JAMA (1884)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
IRON AND BLOOD REGENERATION
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Rapid and strong human CD8+ T cell responses to vaccination with peptide, IFA, and CpG oligodeoxynucleotide 7909
Authors: Daniel E. Speiser, Danielle Liénard, Nathalie Rufer, Verena Rubio-Godoy, Donata Rimoldi, Ferdy Lejeune, Arthur M. Krieg, Jean-Charles Cerottini, Pedro Romero
Journal: Journal of Clinical Investigation (2005)

The induction of potent CD8 + T cell responses by vaccines to fight microbes or tumors remains a major challenge, as many candidates for human vaccines have proved to be poorly immunogenic.Deoxycytidyl-deoxyguanosin oligodeoxynucleotides (CpG ODNs) trigger Toll-like receptor 9, resulting in dendritic cell maturation that can enhance immunogenicity of peptide-based vaccines in mice.We tested whether a synthetic ODN, CpG 7909, could improve human tumor antigen-specific CD8 + T cell responses.Eight HLA-A2 + melanoma patients received 4 monthly vaccinations of low-dose CpG 7909 mixed with melanoma antigen A (Melan-A; identical to MART-1) analog peptide and incomplete Freund's adjuvant.All patients exhibited rapid and strong antigenspecific T cell responses: the frequency of Melan-A-specific T cells reached over 3% of circulating CD8 + T cells.This was one order of magnitude higher than the frequency seen in 8 control patients treated similarly but without CpG and 1-3 orders of magnitude higher than that seen in previous studies with synthetic vaccines.The enhanced T cell populations consisted primarily of effector memory cells, which in part secreted IFN-γ and expressed granzyme B and perforin ex vivo.In vitro, T cell clones recognized and killed melanoma cells in an antigen-specific manner.Thus, CpG 7909 is an efficient vaccine adjuvant that promotes strong antigenspecific CD8 + T cell responses in humans. ResultsVaccination with CpG 7909, peptide, and IFA caused no major side effects.Eight HLA-A2 + patients with advanced melanoma disease received 4 monthly subcutaneous injections of low doses of CpG 7909, Melan-A analog peptide, and IFA.Vaccination with this novel
Solitary hyperfunctioning thyroid adenoma in a child. Elevated T3 and T4 levels with normal TSH level
Authors: H. C. Taylor
Journal: JAMA (1975)

THYROTOXICOSIS in the prepubertal patient is almost invariably due to Graves disease. The recent report of Popma et al<sup>1</sup>underscores, however, the responsibility of the solitary hyperfunctioning nodule for clinically significant hyperthyroidism in the pediatric patient. To our knowledge, this communication presents the second chemically documented example of hyperthyroidism due to a benign solitary hyperfunctioning adenoma in a child, and the first to produce both excessive thyroxine (T<sub>4</sub>) and triiodothyronine (T<sub>3</sub>) levels in the face of a normal serum thyroid-stimulating hormone (TSH) level. <h3>Report of a Case</h3> An 11 1/2-year-old girl was first seen in referral during December 1972. A previous physical examination in April 1971 had been normal. In February 1972, her pediatrician noted a right thyroid nodule. History disclosed some increase in sweating and a tendency to use fewer blankets at night. Her mother observed an increased irritability and a preference for the family room
Forty years of full-time medicine at University of Chicago. Evaluation and affirmation
Authors: H. T. Ricketts
Journal: JAMA (1969)

It is common knowledge that for the past two decades or more there has been a steady increase in the number of full-time clinical positions in the medical schools and hospitals of this country. The conditions governing these positions, however, have varied widely. In most cases the schoolrelated hospital provides an office from which the physician emerges to perform his duties as clinical teacher, but in which, or in other quarters of the building, he is permitted to see private patients on a fee-for-service basis. In such cases, an accommodation is reached between the amount of his salary and the amount of his income derived from patients. There are various formulas, based on temporal or fiscal criteria or both, for limiting the activities in the private practice of medicine or surgery. What has just been described is known as "geographic full time." It is distinguished from true full time, in
Thyroid Hormones and Cytogenetic Outcomes in Backpack Sprayers Using Ethylenebis(dithiocarbamate) (EBDC) Fungicides in Mexico
Authors: Kyle Steenland, Leonor Cedillo, James Tucker, Cynthia Hines, Karen Sorensen, James Deddens, Veronica Cruz
Journal: Environmental Health Perspectives (1997)

Ethylenebis(dithiocarbamate) (EBDC) fungicides are used heavily in the United States. EBDCs (e.g., mancozeb, maneb) are metabolized to ethylene thiourea (ETU). The EPA classifies ETU as a carcinogen, based on thyroid and other cancers in rodents, and has restricted the use of EBDCs, while requiring workers to use protective equipment. There are no data on the potential carcinogenicity of EBDCs in humans, and there is only one study on human genotoxicity. ETU is known to cause decreases of thyroxine (T4) and increases in thyroid-stimulating hormone (TSH) in rodents. We have studied cytogenetic outcomes and serum thyroid hormone levels among 49 heavily exposed workers without protective equipment spraying EBDC on tomatoes in Mexico. We also studied 14 lightly exposed landowners and 31 nonexposed controls. Urinary ETU was used to compare exposure between groups. We found an increase in TSH (p = 0.05) among applicators compared to controls, but no decrease in thyroid hormone (T4). We found increases in sister chromatid exchange (p = 0.03) and in chromosome translocations (chromosome aberrations that persist through cell division) for applicators compared to controls (p = 0.05). However, the subset of reciprocal translocations showed a lesser increase (p = 0.24). Our data suggest that EBDCs affect the thyroid gland and the lymphocyte genome among heavily exposed workers. However, our data are limited to subclinical outcomes, are of borderline statistical significance, and should be interpreted with caution.
Editorial Board
Authors: Stephen Mcleod, San Francisco, Daniel Albert, George Bartley, Creig Hoyt, Andrew Schachat, Anita Agarwal, Ike Ahmed, Canada Aung, Singapore Bengtsson, Wiley Chambers, Balwantray Chauhan, Emily Chew, Michael Chiang, Mary Cotch, Marjan Farid, Lynn Gordon
Journal: Ophthalmology (2017)
FOXO1 Activation Is an Effector of SYK and AKT Inhibition in Tonic BCR Signal-Dependent Diffuse Large B-Cell Lymphomas
Authors: Przemyslaw Kiliszek, Maciej Szydlowski, Tomasz Sewastianik, Ewa Jablonska, Emilia Bialopiotrowicz, Patryk Gorniak, Anna Polak, Sergiusz Markowicz, Eliza Nowak, Monika A. Grygorowicz, Monika Prochorec-Sobieszek, Anna Szumera-Cieckiewicz, Agata Malenda, Ewa Lech-Maranda, Krzysztof Warzocha, Przemyslaw Juszczynski
Journal: Blood (2015)
JAMA Reference Directories
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Gastrointestinal illness on passenger cruise ships
Authors: M. H. Merson
Journal: JAMA (1975)

Medical logs of 2,445 cruises taken by 38 vessels over a 20-month period beginning Jan 1, 1972, were reviewed. On 92% of the cruises, the recorded incidence of gastrointestinal illness was 1% or less; on 2% of cruises, it was 5% or greater. The actual incidence of gastrointestinal illness determined by a questionnaire survey of passengers sailing on nine cruises was found to be at least four times as high as that recorded in the medical logs. Although the cause of the illnesses was not known, there was evidence that transmission took place aboard ship. A survey of food-handling practices and water systems aboard selected ships demonstrated a significant potential for transmission of foodborne and waterborne disease. (<i>JAMA</i>231:723-727, 1975)
Rubella vaccination during an epidemic
Authors: T. Furukawa
Journal: JAMA (1970)

A boys' school in Japan has suffered recurrent epidemics of rubella. Two epidemics occurred in 1969 which provided the opportunity to test the efficacy of the RA 27/3 rubella strain administered either subcutaneously or intranasally. At the outset of the first epidemic, some of the boys were given RA 27/3 rubella vaccine subcutaneously, whereas in the second RA 27/3 rubella vaccine given intranasally was tested. Good antibody responses were shown in vaccinees inoculated by both routes. As compared to unvaccinated controls, there was a sharp reduction in rubella cases among the vaccinees two weeks after inoculation. The protection produced by subcutaneous vaccination with RA 27/3 in the first epidemic was highly significant statistically. The second epidemic was too small for definite judgment, but intranasal administration of RA 27/3 also appeared to be effective.
The Embryology of the Pig.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ADDITIONAL DIAGNOSTIC VALUE OF CT PERFUSION OVER CORONARY CT ANGIOGRAPHY IN STENTED PATIENTS WITH SUSPECTED IN-STENT RESTENOSIS OR CORONARY ARTERY DISEASE PROGRESSION: ADVANTAGE STUDY PRELIMINARY RESULTS
Authors: Daniele Andreini, Saima Mushtaq, Gianluca Pontone, Jeroen Sonck, Edoardo Conte, Marco Guglielmo, Andrea Baggiano, Mauro Pepi, Antonio Bartorelli
Journal: Journal of the American College of Cardiology (2018)
Expression of vascular endothelial growth factor-b in human astrocytoma
Authors: Jean Christophe Gollmer, Annie Ladoux, Jeanine Gioanni, Philippe Paquis, Alain Dubreuil, Marcel Chatel, Christian Frelin
Journal: Neuro-Oncology (2000)

Growth of human malignant gliomas is stringently dependent on an angiogenic process that probably involves vascular endothelial growth factor (VEGF). Expressions ofmRNA coding for the different forms of VEGF were analyzed in surgical specimens from human astrocytomas.Low levels of placental growth factor (PGF) and VEGFC mRNA were observed in polymerase chain reaction, but not in Northern blot experiments.VEGF mRNA was found in some but not all grade and grade IV astrocytomas.VEGFB mRNA was observed in all tissue samples analyzed irrespective of the tumor grade.A new splice variant of VEGFB (VEGFB 155 ) that lacks exons 5 and 6 is described.Expressions of VEGF mRNA in cultured glioblastomas cells were upregulated by hypoxia, but the sensitivity of the cells to hypoxia was reduced as compared with normal rat astrocytes.VEGF expression was depressed by dexamethasone.Expressions of VEGFB mRNA were affected neither by hypoxia nor by dexamethasone.The results indicate a coexpression of VEGF mRNA and VEGFB mRNA in human astrocytomas.Expression of VEGFB is markedly different from that of VEGF.Possible roles of VEGFB as a cofactor for hypoxia-induced angiogenesis in human astrocytomas are discussed.
Vegetarian Diet
Authors: Glenn D. Toppenberg
Journal: JAMA (1974)

<h3>To the Editor.—</h3> The comments of Dr. Mann (227:88, 1974) might well leave the impression that to raise a child as a vegetarian is not done and would be nearly impossible, irresponsible, and ethically incorrect. I would take strong exception. "The majority of populations in economically less-developed countries of Asia, Africa, and Latin America habitually subsist on inexpensive, vegetarian diets, made up of high starch and grains."1 This may well make up the greater proportion of our world's population. To illustrate vegetarian child-raising firsthand, my three children are now the third generation of my family to have never tasted meat, and it certainly has not been detrimental to our health. My 13-year-old high-school boy at 6′3″ and size-14 shoes can hardly be accused of retarded physical growth, and all three children are at the top of their classes at school and are socially well adjusted. My wife, far from being
From the Assistant Secretary for Health
Authors: R. E. Windom
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
LOST MEMBERSHIP.
Journal: JAMA (1883)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal