tbuckley/cabot-search huggingface dataset:
Economy in the Use of Drugs in War-Time. With an Appendix Giving a List of Drugs of Which Production Within the British Empire Sould be Encouraged
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Surrogacy
Authors: Diana Jolliffe, Sarah Videlo
Journal: BMJ (2010)

Some mothers have much to give but so much to lose “I do hope you don’t mind,” my obstetric colleague told me, “but I have said that all the parents may attend the caesarean section.” The patient was a healthy, happily married woman who was expecting twins. She enjoyed being pregnant and her own three children had been easy deliveries. Having completed her family she wanted to help childless couples and had considered becoming an egg donor; then she learnt about surrogacy. Her fourth baby was delivered at home as planned and was for another couple. This pregnancy was a surrogate one—hence the two extra people in theatre and my need for an urgent tutorial on surrogacy. In a surrogacy arrangement a woman (the surrogate mother) agrees to bear a child for someone else (the intended parents) and hand over the baby at birth.1 The arrangement may have an altruistic or commercial basis. In the United Kingdom, altruistic surrogacy—where there are no financial incentives—is the only legal form of surrogacy, but such arrangements are not legally binding (even if a contract has been signed and money has changed hands).2 Surrogate pregnancies are increasing as fewer children are available for adoption and IVF techniques are improving.3 It is estimated by Surrogacy UK (www.surrogacyuk.org) that there have been 700 surrogate pregnancies in the UK.
Harmful Effects of Ultraviolet Radiation
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical and radiological characteristics of lung disease in inflammatory bowel disease
Authors: R. Mahadeva, G. Walsh, C.D.R. Flower, J.M. Shneerson
Journal: European Respiratory Journal (2000)

The pulmonary associations of inflammatory bowel disease (IBD) are poorly characterized. The clinical, physiological and high-resolution computed tomographic thorax characteristics of the lung disease in patients with IBD presenting with respiratory symptoms are described. Detailed clinical information was obtained and standard pulmonary physiological tests and thorax high-resolution computed tomography performed on 14 patients with ulcerative colitis (UC) and three with Crohn9s disease (CD), 10 male, aged 38-83 yrs. Respiratory symptoms had been present for 2-50 yrs and extraintestinal manifestations were present in three (17.6%). Normal pulmonary physiology (six patients) was associated with the high resolution computed tomographic changes of bronchiectasis, mosaic perfusion and air trapping suggestive of obliterative bronchiolitis and a pattern of centrilobular nodules and branching linear opacities ("tree in bud" appearance) suggestive of either cellular bronchiolitis or bronchiolectasis with mucoid secretions. Bronchiectasis was found in 13 patients (11 UC, 2 CD), 11 had air trapping and five had a "tree in bud" appearance on computed tomography. One patient had a predominantly peripheral reticular pattern at the lung bases similar to that found in cryptogenic fibrosing alveolitis and one patient had a mixed reticular and ground-glass pattern in the midzones with a patchy distribution in the central and peripheral portions of the lungs with air trapping. Eleven patients (three with alveolitis) exhibited a clinical and/or physiological response to steroids. Pulmonary abnormalities in ulcerative colitis and Crohn9s disease can present years after the onset of the bowel disease and can affect any part of the lungs. Early recognition is important as they can be strikingly steroid-responsive.
Abstract 2948: Novel cell line barcoding method reveals tepoxalin as a selective drug against MDR1-high tumor cells
Authors: Steven M. Corsello, Ryan D. Spangler, Rohith T. Nagari, Mustafa Kocak, Jordan Rossen, Patrick O'Hearn, Jennifer Roth, Alfredo Gonzalez, Nancy Dumont, John Doench, Jesse S. Boehm, Francisca Vazquez, Aviad Tsherniak, Todd R. Golub
Journal: Cancer Research (2019)

Abstract Drug repurposing for cancer therapy has seen notable success, such as the reintroduction of thalidomide. To discover new indications, all existing drugs known to be safe should be systematically evaluated for anti-cancer properties. However, given cost and throughput considerations, phenotypic screens are typically limited along the cell line (e.g., NCI-60 cell lines) or compound dimension (e.g., testing only several hundred cancer drugs). To identify new repurposing opportunities at scale, we tested more than 4,600 existing drugs for cytotoxicity against 578 diverse cancer cell lines using PRISM, a recently developed multiplexed cell viability assay. High gene expression of the ABCB1 transporter (MDR1/p-glycoprotein) was strongly correlated with resistance to numerous approved cancer therapeutics including taxanes, anthracyclines, vinca alkaloids, and proteasome inhibitors. Surprisingly, we identified a single drug, tepoxalin, with the opposite profile: selective activity against MDR1-high cancer cell lines. Tepoxalin, an oral cyclooxygenase inhibitor, is FDA-approved for treatment of osteoarthritis in dogs and was previously found to be safe in human trials. To evaluate for alternative mechanism of action and genomic mediators of tepoxalin resistance, we conducted pooled genome-wide CRISPR-Cas9 modifier screens in the LS1034 colorectal cancer cell line. The CRISPR knockout screen revealed ABCB1 as the top enriched gene mediating tepoxalin resistance, while the CRISPR activation screen revealed ABCB1 as the top depleted gene. Overexpression of ABCB1 in ovarian cancer cell lines also sensitized to tepoxalin killing. Small molecule combination testing demonstrated rescue of tepoxalin killing by known ABCB1 inhibitors. Future studies will include biophysical characterization of the interaction between tepoxalin and the ABCB1 protein as well as in vivo efficacy testing. Our results demonstrate that tepoxalin or related derivatives may be useful in the treatment of chemotherapy-resistant colorectal cancer, ovarian cancer, lymphoma, and other malignancies. Citation Format: Steven M. Corsello, Ryan D. Spangler, Rohith T. Nagari, Mustafa Kocak, Jordan Rossen, Patrick O'Hearn, Jennifer Roth, Alfredo Gonzalez, Nancy Dumont, John Doench, Jesse S. Boehm, Francisca Vazquez, Aviad Tsherniak, Todd R. Golub. Novel cell line barcoding method reveals tepoxalin as a selective drug against MDR1-high tumor cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2948.
Scabies presenting as urticaria
Authors: T. A. Chapel
Journal: JAMA (1981)

Three cases of urticaria developed in patients with scabies. The hives promptly disappeared after treatment with lindane (gamma benzene hexachloride). In two of the patients, physicians initially diagnosed and treated the urticaria but overlooked the scabies infestation. The point of emphasis in these cases is the occasional association of urticaria with<i>Sarcoptes scabiei</i>infestation. (<i>JAMA</i>1981;246:1440-1441)
Errors in Results Section and Figure 2
Authors: Scott Grosse
Journal: JAMA Pediatrics (2014)

Susan Wu, MD; Chris Baker, MD; Michael E. Lang, MD, MPH; Sheree M. Schrager, PhD, MS; Fasha F. Liley, MD; Carmel Papa, MS-HCA; Valerie Mira, MPH; Ara Balkian, MD, MBA; Wilbert H. Mason, MD, MPH
Leads from the MMWR. Dengue and dengue hemorrhagic fever in the Americas, 1986
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Scotland
Journal: BMJ (1907)

r IOr I 0I members of the Health Committee professed great sympathy with medical men on the ground that theyhave to do so much public work for nothing.Medical men will nw know how much value to place on such sympathy, and not until the Committee, recently appointed by the Divisions to watch the interests of medical men at municipal and other elections, gets to work, is there any chance of anything exoept similar empty sympathy.It will probably be said by the Health Committee that medical men ought to apply to the guardians for a fee in- eases where the patient is too poor to pay.It is well known in Salford what that means-endless trouble for the doctor in laying his case before the guardians, and inquisitorial visits by Poor-law officers to the patient's home, inflicting the stigma of pauperism on women whom the superviiing authority, not the guardians, has practi- cally compelled .tohave a doctor, when often she would have been conteut with the midwife.It is not about paupers that the dispute arises, for they are sufficiently provided for already.It is the class just above the pauper elass that is so nearly concerned, women just able by dint of the hardest struggling to get the barest liviing from day to day.This class, the Salford Health Committee says, inust in future be treated as paupers.
NONCOMMUNICABLE STREPTOCOCCI
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tuberculose im Kindesalter
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Outcome of First Hospitalization of Patients with Schizophrenia
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Thoracic Surgery
Authors: J. Gordon Scannell
Journal: New England Journal of Medicine (1952)

TuberculosisThe past four years, the first of the streptomycin era, have seen great changes in the surgical treatment of tuberculosis. Many of these undoubtedly represent progress. As a general rule, they have been along the lines of widening indications and reducing hazards of resection. A brake to enthusiasm, however, is provided by the words of Morriston Davies,103 speaking before the Thoracic Society of Great Britain in 1948:There always has been and will be the feeling of necessity to show one's erudition by doing something. In the past it was incantations and the brewing of loathsome concoctions: then venesection: . . .
The Effects of Acid Precipitation Runoff Episodes on Reservoir and Tapwater Quality in an Appalachian Mountain Water Supply
Authors: William E. Sharpe, David R. DeWalle
Journal: Environmental Health Perspectives (1990)

The aluminum concentration and Ryznar Index increased and the pH decreased in a small Appalachian water supply reservoir following acid precipitation runoff episodes. Concomitant increases in tapwater aluminum and decreases in tapwater pH were also observed at two homes in the water distribution system. Lead concentrations in the tapwater of one home frequently exceeded recommended levels, although spatial and temporal variation in tapwater copper and lead concentrations was considerable. Since source water and reservoir water copper and lead concentrations were much lower, the increased copper and lead concentrations in tapwater were attributed to corrosion of household plumbing. Tapwater copper concentration correlated well with tapwater pH and tapwater temperature. Asbestos fibers were not detected in tapwater. The asbestos-cement pipe in the water distribution system was protected by a spontaneous metallic coating that inhibited fiber release from the pipe. Several simultaneous reactions were hypothesized to be taking place in the distribution system that involved corrosion of metallic components and coating of asbestos-cement pipe components in part with corrosion products and in part by cations of watershed origin. Greater water quality changes might be expected in areas of higher atmospheric deposition.
Further abstracts
Authors: M Uma\, A Canelhas, M Cunha, G Eiwahidi, M Aiawadi, H Saker, A Eishaatand, A Horwich, R Epelbaum, C Shalitin, R Segal, C Valansi, I Arsdan, D Faraggi, M Leviov, M Ben-Shahar, N Haim
Journal: Annals of Oncology (1996)
Issue Information
Authors: Richard Bucala, Daniel Solomon, Joseph Craft, New Haven, David Felson, Richard Loeser, Chapel Hill, Peter Nigrovic, Janet Pope, Christopher Ritchlin, Betty Tsao, John Varga, Robert Terkeltaub, San Diego, Michael Weinblatt, Paul Sufka, St Paul, Shervin Assassi, Vivian Bykerk, New York, Kristin D'silva, Deborah Feldman, Meenakshi Jolly, Linda Li, Uyen-Sa Nguyen, Worth Fort, Oklahoma Scofield, Jane Diamond, Atlanta Ilani, S Lorber, Atlanta Lesley, W Allen, Atlanta Barraza, Atlanta Hamilton, Emily Wehby, Atlanta Stefanie, L Mckain, Atlanta Swett, Haven Galanis, Daniel Aletaha, Heather Allore, Daniel Clauw, Ann Arbor, Robert Colbert, Karen Costenbader, Nicola Dalbeth, Kevin Deane, Mark Genovese, Palo Alto, Insoo Kang, Wan-Uk Kim, Carol Langford, Cleveland Liao, Boston Lim, Anne-Marie Malfait, Paul Monach, Chester Oddis, Andras Perl, Jack Porrino, Timothy Radstake, William Robinson, Georg Schett, Nan Shen, Shanghai Van Vollenhoven, Fredrick Wigley, Abhishek Abhishek, Tom Appleton, Bonnie Bermas, Liana Fraenkel, Monica Guma, La Jolla, Nigil Haroon, Erica Herzog, Hui-Chen Hsu, J Kahlenberg, Mariana Kaplan, Jonathan Kay, Francis Lee, Sang-Il Lee, Rik Lories, Bing Lu, Suresh Mahalingam, Aridaman Pandit, Kevin Winthrop, Kazuki Yoshida, Ellen Gravallese, David Karp, Douglas White, La Crosse, Kenneth Saag, Steven Echard, William Phelps Arend, Nikolay Nikolov, Sally Seymour, Rosemarie Neuner, John Fitzgerald, Ted Mikuls, Romina Brignardello-Petersen, Gordon Guyatt, Aryeh Abeles, Allan Gelber, Leslie Harrold, Dinesh Khanna, Charles King, Gerald Levy, Caryn Libbey, David Mount, Michael Pillinger, Ann Rosenthal, Jasvinder Singh, James Sims, Benjamin Smith, Neil Wenger, Sharon Sangmee, Abhijeet Bae, Puja Danve, Seoyoung Khanna, Aleksander Kim, Samuel Lenert, Anila Poon, Shiv Qasim, Tarun Sehra, Kumar Sudhir, Michael Sharma, Marat Toprover, Linan Turgunbaev, Mary Zeng, Lorna Gallagher, Sian Cregan, Monika Biniecka, Clare Cunningham, Douglas Veale, David Kane, Ursula Fearon, Ronan Mullan, Isabelle Auger, Nathalie Balandraud, Emmanuel Massy, Marie Hemon, Elisa Peen, Fanny Arnoux, Charlotte Mariot
Journal: Arthritis & Rheumatology (2020)
Table of contents
Authors: Alan Geller, Susan Swetter, Katie Brooks, Marie-France Demierre, Amy Yaroch, Joaquim Marcoval, Abelardo Moreno, Jordi Peyrı, Barcelona Spain, M Husni, Kathryn Meyer, Darel Cohen, Elinor Mody, Abrar Qureshi, Clara De Simone, Andrea Paradisi, Guido Massi, Ilaria Proietti, Angela Capponi, Pier Amerio, Rodolfo Capizzi, Aviv Barzilai, Anna Lyakhovitsky, Henri Trau, Mina Fogel, Monika Huszar, Zaid Jasim, Julian Handley, Akhil Wadhera, Emanual Maverakis, Nicholas Mitsiades, Primo Lara, Maxwell Fung, Peter Lynch, Fremont Sacramento
Journal: Journal of the American Academy of Dermatology (2007)
Lithium Ion Toxicity and Pregnancy
Authors: George D. Wilbanks
Journal: JAMA (1970)

<h3>To the Editor.—</h3> The authors wish to thank Drs. Weinstein and Goldfield for their critical review, stressing the intent of the original article which was to caution the use of lithium carbonate during pregnancy, especially in combination with other medications. Diuretics and low sodium diet are known to predispose patients with renal impairment to lithium toxicity and, to a lesser extent, patients with normal renal function.<sup>1</sup>The effects of psychoactive drugs and trihexyphenidyl hydrochloride (Artane) on lithium metabolism, especially during pregnancy and parturition, are not known. Acute manic episodes have been shown to increase the retention of lithium salts in comparison to quiescent periods of the disease.<sup>2</sup>The interactions of all these factors may have contributed to the toxicity occurring in our patient. In reply to the specific questions of Drs. Weinstein and Goldfield, the amount of lithium carbonate the patient received was taken from the nursing notes