tbuckley/cabot-search huggingface dataset:
The role of Kupffer cells in the differentiation process of hepatic natural killer cells
Authors: K VANDERKERKEN
Journal: Hepatology (1995)

Pit cells, or hepatic natural killer (NK) cells, present in rat liver sinusoids, represent an organ-associated NK cell population, with a higher level of activation and a different morphology when compared with peripheral blood NK cells. These cells are the result of an influx of peripheral blood NK cells in the liver microenvironment, followed by an activation or differentiation process toward the highly activated phenotype. In this work we investigated the role of Kupffer cells in this differentiation process of NK cells in the liver sinusoids. In vivo elimination of Kupffer cells with the macrophage cytotoxic drug dichloromethylene diphosphonate induced a decrease in number of hepatic NK cells that paralleled that of Kupffer cells. This effect was further investigated in vitro. Kupffer cell-conditioned medium appeared to enhance the viability, tumor-cytotoxic activity, and adherence of hepatic NK cells to liver endothelial cells in vitro. We conclude therefore that Kupffer cells, present in the microenvironment of the liver sinusoids, play an essential role in the differentiation process of peripheral blood NK cells to the highly activated hepatic NK cell population. (HEPATOLOGY 1995; 22:283–290.)
Deformity and character. Dr Little's diagnosis of Richard III
Authors: P. J. Accardo
Journal: JAMA (1980)

THROUGH the first half of the 19th century, obstetric textbooks stated that asphyxiated babies either died or recovered completely. William John Little described the possibility of a third outcome—movement disorders that would not become apparent until a year or more after the initial insult. In the discussion following the delivery of his classic paper on cerebral palsy before the London Obstetrical Society,<sup>1</sup>Dr Little mentioned that he had not found any references to the long-term effects of abnormal and premature parturition in the medical literature. Recognizing the novelty of his insight, he had recourse to Shakespeare for the earliest suggestion of adult deformity secondary to neonatal asphyxia. Without criticizing the historical accuracy of Shakespeare's portrait of King Richard III, he was convinced that the poetic description of Richard's physical and moral character was "exactly that of an individual afflicted with one kind of deformity originating at birth." Delivered after
Council on Drugs
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Heat Pyrexia
Authors: James J. Short
Journal: JAMA (1960)

<h3>To the Editor:—</h3> I was much interested in the article inThe Journal, July 16, page 1175, entitled "Development of Heat Pyrexia," by Captain Joseph Gold (MC), U. S. Air Force. Failure of the sweating mechanism is, of course, the immediate reason for the hyperpyrexia. Captain Gold's controlled experiments indicate the circumstances which lead to this failure. His controlled laboratory experiments, however, are somewhat different in course and outcome from those seen clinically. During World War II, at Parris Island, S. C., as chief of medicine at the U. S. Naval Hospital, I saw a large number of cases of heat stroke. These patients were completely unconscious when brought to the hospital; their skin was dry and their temperature extremely high. One patient had a temperature of 111°F. (44°C.) in the axilla. He was treated by cold applications over the body, with forced air circulation to aid evaporation. However, he
Book Review A Bibliography of Aviation Medicine . Prepared for the Committee on Aviation Medicine, Division of Medical Sciences, National Research Council, acting for the Committee on Medical Research, Office of Scientific Research and Development. By Ebbe C. Hoff, Ph.D., and John F. Fulton, M.D. 4°, cloth, 237 pp. Springfield, Illinois: Charles C Thomas, 1942. $4.00.
Journal: New England Journal of Medicine (1942)
I. Membership of Committees on Education (as of June 30, 1991)
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
This Week in &lt;EMPH&gt;JAMA&lt;/EMPH&gt;
Journal: JAMA (2004)

Sunil V. Rao, MD; James G. Jollis, MD; Robert A. Harrington, MD; Christopher B. Granger, MD; L. Kristin Newby, MD; Paul W. Armstrong, MD; David J. Moliterno, MD; Lauren Lindblad, MS; Karen Pieper, MS; Eric J. Topol, MD; Jonathan S. Stamler, MD; Robert M. Califf, MD
Abdominal Pain
Authors: C W Venables
Journal: Gut (1980)

Management of inflammatory bowel disease has become more precise and effective in the last 30 years, ensuring long, productive lives for most patients. Data such as family history, duration of disease, the onset of complications, and type of therapy are presented from 450 patients with inflammatory bowel disease treated during a 10-year period ending in 1984. The incidence of general complications over three decades is compared. Perianal disease and intestinal obstructions dominate complications of Crohn’s disease. The most common nongastrointestinal complication for patients with either disease is monarticular large joint arthritis. Approximately 75% of patients with Crohn’s disease will eventually undergo surgery. In the first decade of data collection, 50% of patients with ulcerative colitis had surgery; in the second decade, 26%; and in the third decade, 39%. The changing percentages correspond initially to advances in medical therapy and then to advances in surgical therapy.
Automation of electrocardiographic diagnostic criteria
Authors: J. R. Whiteman
Journal: JAMA (1967)

A complete system with capabilities to provide automatic clinical evaluations of standard 12-lead electrocardiograms has been developed. The basic equipment includes a magnetic tape ECG machine and a mediumsized digital computer. The computer accepts data directly by telephone or by tape playback. Each of the 12 leads is converted to digital samples, measured, and stored. A three-step program then recalls the measurements to be condensed, combined, and refined to one or several diagnostic statements. These are immediately available for use at the processing center or may be transmitted by teletype to the clinical site.
Abstract 62: Functional mechanism of cyclosporin A therapy for immunoglobulin-resistant Kawasaki disease
Authors: Nobuyuki Kakimoto, Hiroyuki Suzuki, Tomohiro Suenaga, Takashi Takeuchi, Shoichi Shibuta, Jun Abe, Norishige Yoshikawa
Journal: Circulation (2015)

Background: We have reported that cyclosporin A (CsA) therapy may be a promising and safe option for patients with Kawasaki disease (KD) resistant to initial and additional intravenous immunoglobulin (IVIG). Up to now, it has been considered that CsA exerts effects on the intracellular phosphatase calcineurin, and subsequently inhibits activation of nuclear factor of activated T cells (NFAT). However, the functional mechanism of CsA therapy in KD patients has remained unclear. Methods: The KD patients enrolled in this study were treated with CsA between April 2012 and December 2013. In accordance with our treatment protocol, KD patients are initially treated with IVIG and aspirin. If there is no response, a further course of IVIG is given, and if there is no response to this additional IVIG, the patients are treated with CsA. Peripheral blood samples were obtained just before and after the initial course of IVIG, additional IVIG, and CsA therapy. To evaluate the NFAT pathway and activation of the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway, we examined the gene expression of cytokines and intracellular signal transducers using real-time RT-PCR and phospho-STAT3 (pSTAT3) and STAT5 (pSTAT5) using flow cytometry. Results: Thirty-six KD patients were divided into three groups: responsive to initial IVIG (n=19), responsive to additional IVIG (n=7), and treated with CsA group (n=10). In the CsA group, expression of mRNAs for interleukin (IL)-2, NFATc1 and NFATc2 was significantly increased, whereas the mean fluorescence intensity (MFI) of pSTAT3 (CD3+ T cell) and pSTAT3 (CD16b+ granulocyte) was decreased after CsA treatment. In the group responsive to initial IVIG, the expression of mRNAs for IL-2, IL-6, NFATc1 and NFATc2 was significantly increased, whereas that for STAT3, 5A, 5B was decreased after IVIG treatment; on the other hand, the MFI of pSTAT3 (CD3+ T cell) and pSTAT3 (CD16b+ granulocyte) was decreased, and that of pSTAT5 (CD16b+ granulocyte) was increased, after IVIG. Conclusion: In patients with refractory KD, CsA exerts effects on the activity of the NFAT and JAK-STAT pathways. However, our results suggest that in patients with immunoglobulin-resistant KD, CsA may act through a mechanism other than the NFAT pathway.
Comparison of intra-amniotic prostaglandin F2 alpha and hypertonic saline for induction of second-trimester abortion.
Journal: BMJ (1976)

The efficacy and safety of intra-amniotic prostaglandin (PG) F2 alpha (25 mg repeated in six hours) and hypertonic saline (200 ml 20% NaC1) were compared in an international multicentre randomised study organised by the World Health Organisation's prostaglandin task force. Both hypertonic saline and PGF2alpha were found to be effective in terminating second-trimester pregnancy. The main advantage of PGF2alpha however, was its greater efficacy, with significantly higher success rates in the first 48 hours. Out of 717 women given PGF2alpha 614 (85-6%) aborted within 48 hours; by 24 hours 439 (61-2%) had aborted, and by 36 hours 574 (80-1%) had aborted. Out of 796 women given hypertonic saline 641 (80-5%) aborted within 48 hours; however, by 24 and 36 hours, respectively, only 161 (20-2%) and 462 (58%) had aborted. Although PGF2alpha was associated with a somewhat higher frequency of minor side effects than hypertonic saline, notably vomiting and diarrhoea, these were within acceptable limits. Only 59 women (8-2%) in the prostaglandin group had more than four episodes of vomiting and 11 (1-5%) more than four episodes of diarrhoea. Ohter side effects occurred only occasionally. No difference was found between the two groups in the frequency of incomplete abortion or excessive bleeding.
Handbuch der Gesamten medizinischen Anwendungen der Elecktrizität inschliesslich der Röntgenlehre.
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Radon in homes. Council on Scientific Affairs
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Le métabolisme de l'azote: Dépenses, besoins, couverture.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction: ABC of sexually transmitted diseases
Journal: BMJ (1983)

much the same but it has been brought up to date with some new illustrations-for example, table 7.2 comparing the proper- ties of Gutta-Percha and Silverpoint-and new sections: causes of pain after preparation and medication of the pulp cavity, conventional root canal therapy, and hemisection and trisection.There was only one line mentioning fluoridation, but this is because another in this series (No 20) deals with this subject.
Factors Associated with the Development of Antibiotic-Resistant Bacteria
Journal: Annals of Internal Medicine (2001)

Summaries for Patients7 August 2001Factors Associated with the Development of Antibiotic-Resistant BacteriaSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-135-3-200108070-00005 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Unnecessary use of antibiotics is thought to be an important cause of bacterial resistance to antibiotics. One type of bacteria known as vancomycin-resistant enterococci (VRE), which is usually found in the bowel, can cause serious or fatal infections and is extremely difficult to treat. Limited information is available on exactly where VRE occur in hospitals and what factors are associated with their presence.Why did the researchers do this particular study?To evaluate how patterns of antibiotic use affected the frequency of finding VRE in hospital intensive care ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “The Effect of Vancomycin and Third-Generation Cephalosporins on Prevalence of Vancomycin-Resistant Enterococci in 126 U.S. Adult Intensive Care Units.” It is in the 7 August 2001 issue of Annals of Internal Medicine (volume 135, pages 175-183). The authors are SK Fridkin, JR Edwards, JM Courval, H Hill, FC Tenover, R Lawton, RP Gaynes, and JE McGowan Jr., for the Intensive Care Antimicrobial Resistance Epidemiology (ICARE) Project and the National Nosocomial Infections Surveillance (NNIS) System Hospitals.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe Effect of Vancomycin and Third-Generation Cephalosporins on Prevalence of Vancomycin-Resistant Enterococci in 126 U.S. Adult Intensive Care Units Scott K. Fridkin , Jonathan R. Edwards , Jeanne M. Courval , Holly Hill , Fred C. Tenover , Rachel Lawton , Robert P. Gaynes , John E. McGowan Jr. , and Metrics 7 August 2001Volume 135, Issue 3Page: I-27KeywordsAntibioticsBacteriaInpatientsIntensive care unitsNosocomial infectionsNumber needed to inviteOutpatient clinicsSurgeryVancomycinVancomycin resistant enterococcus ePublished: 7 August 2001 Issue Published: 7 August 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Abstract 3615: Design for a flexible localized drug delivery system
Authors: Marzenna Wiranowska, Ryan Toomey, Rana Falahat, Norma Alcantar
Journal: Cancer Research (2019)

Abstract This project focuses on studying the optimal design of a drug delivery system based on niosomes (non-ionic surfactants vesicles) embedded in a hydrogel network (chitosan) to ensure full control of the release time and dosage of cancer treatment drugs for localized delivery. Here we present data on the molecular interactions facilitating specific binding at tumor cell surfaces to aid in the treatment of ovarian, brain and lung cancers to name a few. We have done three types of characterizations to determine the basic design parameters for a personalized cancer treatment. First, we determined how fundamental surface interactions can be optimized to target and attack tumor integrity and boundaries. We used confocal microscopy and Xenogen imaging to determine how data from cells and in-vivo models compare. Second, we determined the parameters of chemotherapeutic agents that can act individually or in a cocktail configuration in both in-vitro and in-vivo studies. We used light scattering and transmission electron microscopy to determine the topography for guidance on the design of the drug delivery process. Third, we found that specific targeting can be accomplished by optimizing the binding between drug molecules and mucin 1 (MUC1) found on the surface of epithelial-derived tumors. We used attenuated total internal reflection Fourier transform infrared (ATR-FTIR) spectroscopy to elucidate the interactions that enhance the selectivity of our drug delivery system with respect to model cancer systems. In addition, we used chlorotoxin, a carrier-type polypeptide known to bind to a broad number of tumors. By identifying and optimizing these two methodologies, we have found that tumor and normal cells can be selectively targeted. The significant advantage of applying a localized treatment is the avoidance of systemic exposure to chemotherapy drugs thereby limiting their side effects. Citation Format: Marzenna Wiranowska, Ryan Toomey, Rana Falahat, Norma Alcantar. Design for a flexible localized drug delivery system [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3615.
Serum amyloid A impairs the antiinflammatory properties of HDL
Authors: Chang Yeop Han, Chongren Tang, Myriam E. Guevara, Hao Wei, Tomasz Wietecha, Baohai Shao, Savitha Subramanian, Mohamed Omer, Shari Wang, Kevin D. O’Brien, Santica M. Marcovina, Thomas N. Wight, Tomas Vaisar, Maria C. de Beer, Frederick C. de Beer, William R. Osborne, Keith B. Elkon, Alan Chait
Journal: Journal of Clinical Investigation (2016)
A prospective study on the incidence of delayed nausea and vomiting following administration of carboplatin-containing regimens for treatment of cancer without prophylactic aprepitant.
Authors: C. Pflederer, B. W. Goodgame, D. Morgensztern, F. Gao, R. Govindan, M. Q. Baggstrom
Journal: Journal of Clinical Oncology (2010)

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