tbuckley/cabot-search huggingface dataset:
First Call for AMA-RPS Interim Meeting
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effects of Soybean Flour on the Pancreas of Rats
Authors: Eileen E. McGuinness, Reginald G. H. Morgan, Kenneth G. Wormsley
Journal: Environmental Health Perspectives (1984)

We have reviewed the growth-promoting and carcinogenic effects of feeding raw soya flour to rats. If the raw soya flour-containing diets are fed for more than a year, about 10% of the animals develop pancreatic cancer. In addition, feeding raw soya flour markedly potentiates the action of even subthreshold amounts of pancreatic carcinogens. The raw soya flour therefore acts as a potent promoter, as well as a weak carcinogen. In view of this promotion, the rat fed raw soya flour is a sensitive model for screening pancreatic carcinogens. It is not known whether the human pancreas responds to dietary trypsin inhibitors in a manner similar to the rat. However, in view of the use of soya-based products in human nutrition--especially in infant foods--we urge that the effect of all soya-based products intended for human use be tested on the rat pancreas in long-term feeding studies, combined with subthreshold doses of azaserine to highlight any promoting activity of the product. It seems probable that if a product exerts no effect on the rat pancreas, the human pancreas will also be spared from noxious effects.
Smoking and health
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Understanding consequences of concurrent therapies
Authors: C. C. Peck
Journal: JAMA (1993)

In 1989, the occurrence of a rare, life-threatening ventricular arrhythmia (torsades de pointes) in an otherwise healthy young woman led alert clinicians at the Naval Hospital in Bethesda, Md, to consider the possibility that the patient's near-fatal arrhythmia was triggered by a drug-drug interaction involving her antihistamine (terfenadine) and her antifungal (ketoconazole) medications.<sup>1</sup>Consulting clinical pharmacologists from the Uniformed Services University of the Health Sciences and the US Food and Drug Administration (FDA) suggested that ketoconazole inhibited the oxidative metabolism of terfenadine. Analysis of blood samples revealed that the patient had high levels of unmetabolized terfenadine, a compound not usually detectable in blood because it is metabolized so quickly. Review of reports to the FDA's spontaneous reporting system revealed that among additional cases of torsades de pointes in patients receiving terfenadine, many were also receiving ketoconazole. This evidence led the FDA to ask Marion Merrill Dow, Kansas City, Mo,
TRANSFUSION OF CITRATED BLOOD
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Therapy of B-Cell Malignancies by Anti-HLA-DR Humanized Monoclonal Antibody, IMMU-114, Is Mediated through Hyperactivation of ERK and JNK MAP Kinase Signaling Pathways.
Authors: Pankaj Gupta, Rhona Stein, Thomas M Cardillo, Richard R Furman, Susan Chen, Chien-Hsing Chang, David M. Goldenberg
Journal: Blood (2009)
Primary hypertension: a disease
Authors: G. A. Perera
Journal: JAMA (1970)

<h3>To the Editor.—</h3> Is it not time that a stamped, self-addressed envelope accompany requests for reprints? If this practice became standard procedure what a boon it would be to an overworked force, and incidentally to authors! Contraction from a large office force intensifies the problem of dealing with reprints. Retirement, blessed with releases, enforces restraints and strictures that accompany loss of position. Since my retirement (June 30, 1967), this office has had reprint requests in excess of 2,500 during a period of 40 months. Only twice have selfaddressed, stamped envelopes accompanied the request, which usually arrives in the form of a printed postcard. The only claim authors have upon emolument for journal publications is demonstration of reader interest, aside from the expectant hope, too often doomed to disappointment, that something helpful or durable may emerge from the effort. In 1931, as Harvey Cushing was contemplating leaving his post at the
Symposium on the Diagnosis and Treatment of Bone Tumors
Journal: JNCI Journal of the National Cancer Institute (1979)

Symposium on the Diagnosis and Treatment of Bone Tumors Get access JNCI: Journal of the National Cancer Institute, Volume 63, Issue 2, August 1979, Page 533, https://doi.org/10.1093/jnci/63.2.533-d Published: 01 August 1979
Medical educators confront the future
Authors: C. Marwick
Journal: JAMA (1995)

MEDICAL EDUCATORS are becoming more aggressive in their efforts to come to grips with the inevitable changes affecting their world. At the annual meeting of the Association of American Medical Colleges (AAMC), in Washington, DC, President Jordan J. Cohen, MD, presented a plan for dealing with "a new era of constrained resources and heightened accountability for the nation's health care." The title of the 20-page report, released at the meeting, is<i>Taking Charge of the Future—The Strategic Plan for the Association of American Medical Colleges</i>. Even as it affirms that "[a]cademic medicine's central challenge is the preservation of its societal missions in the midst of a complex and unduly market-driven transformation of the health care system," the AAMC report states that "[w]e must be prepared to change whatever is out of alignment with contemporary realities, all the while upholding the values and beliefs responsible for our past successes and essential
Heberden Society: Clinical Meeting, May 1977
Authors: C Erhardt, P Mumford, R Maini
Journal: Annals of the Rheumatic Diseases (1977)

Serum cryoprecipitate levels were raised in 36% of 53 patients with rheumatoid arthritis.We chose a figure in excess of 10 jig/ml protein as representing significant cryoglobulinaemia, based on measure- ments on 21 normal subjects.Analysis of the clinical features of the patients studied shows (a) that raised levels in 19 patients were always associated with extra-articular disease, including nodules 13, digital vasculitis 6, cutaneous vasculitic rash 1, ulcers 3, sensory and/or motor peripheral neuropathies 4, widespread arteritis 1, fibrosing alveolitis 4, and scleritis 5; (b) that raised levels were not found in patients with joint disease alone (n =28, mean 3-5 jig/ml); (c) there was no correlation (P<0 1) between the ESR and amount of cryoprecipitate; (d) 6 patients with extra-articular disease but no significant cryoglobulinaemia had nodules 2, obliter- ative bronchiolitis 1, healing pretibial ulcer 1, and fibrosing alveolitis 2. A significant correlation was found between cryoglobulinaemia and serum rheumatoid factor titres (r=0'45, P<0.001) and 125I-Clq binding activity (r=0.45,P<0.001).An inverse correlation was found with C4 and CH50.These results suggest that cryoglobulinaemia is associated with extra-articular disease in rheumatoid arthritis and that circulating immune complexes are important in the pathogenesis of these lesions.Measurement of cryoprecipitates could be helpful in following the clinical course of such patients.Circulating immune complexes and rheumatoid activity.P. A. Bacon and N. D. Hall.Royal National Hospital for Rheumatic Diseases, Bath.An earlier study has shown circulating immune complexes in active rheumatoid arthritis (RA) which were of a different type to those seen in RA vasculitis.
SCDT-27. CHILDREN’S BRAIN TUMOUR DRUG DELIVERY CONSORTIUM
Authors: Ruman Rahman, Richard Grundy, Emma Campbell, Henry Brem, Monica Pearl, Jordan Green, Miroslaw Janowski, Kenneth Cohen, Piotr Walczak, Katherine Warren, Stephen Lowis, Alexander Mullen, Marie Boyd, Gareth Veal, Darren Hargrave, Dannis van Vuurden, Stephen Powell, David Walker
Journal: Neuro-Oncology (2017)
ABSTRACTS
Journal: Circulation (1956)

The effe(ts of D)ianmox on respiratorv variables and urinarv excietion w ere observed in 7 cases of pulmonary eml)hysemla with chronic CO2 retention.In most instances D)iamlnox indu(ced a co)ious diuresis of alkaline urine (ontaining large quantities of sodium, potassium and bicarbonate.With contin- uous adlministration of the drug, the urinary ex- cretion pattein reverted to control values within a few (lays, but metalb)olic acidosis (plasma bicarbonate and )H d(lecreasecl b)elow control values), and the "drv weight" of the patient lersisted throughout the p)eliol of (Irug acllflinistration.The administra- tion of Dianmox resulted in improved alveolar ven- tilation as measured 1wv increase(l P02 and decreased pC0 after three (lays of (continued dosage.Increase in alveolar ventilation occurredl without a con- sistent increase in minute ventilation, but was al- ways associated waith significant diuresis.Increased alveolar ventilation, as indicated bv increased P02, was noted within four hours after a large, oral dose of Diamox, although the pCO2 of arterial bloo10 increased during this p)eriod.This elevation of pCO2 in the presence of increased alveolar ventila- tion is consi(leredl evidlenc(e for inhibition of carbonic anhydrase a(tivitv of the red (ell.M\lost patients exhibited some symp)tomati( imlprovement for about two weeks on the (drug, followed by return of pretreatment svmlptoIns.In two severely ill patients, Diamox failed to produce significant improvement in the blood abnormalities, an(l did not alter the fatal course of their resl)iratorv acidlosis.
The Sexual Instinct. Its Use and Dangers as Affecting Heredity and Morals.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Council on Physical Therapy
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lipid alterations and decline in the incidence of coronary heart disease in the Helsinki Heart Study
Authors: V. Manninen
Journal: JAMA (1988)

In the Helsinki Heart Study, a randomized five-year, double-blind trial, a 34% reduction in the incidence of coronary heart disease (CHD) was observed in dyslipidemic men treated with gemfibrozil. Averaged over the five years of the trial, gemfibrozil therapy produced, compared with placebo, mean decreases of 10% in serum total cholesterol level, 14% in non-high-density lipoprotein (HDL) cholesterol level, 11% in low-density lipoprotein (LDL) cholesterol level, 35% in triglyceride level, and a mean increase of 11% in HDL cholesterol level from baseline levels measured prior to treatment. While changes in HDL cholesterol level were similar in all Fredrickson types, the effect on concentrations of total cholesterol and LDL cholesterol was largest in type IIA and on LDL minimal in type IV. The reduction of CHD incidence over placebo was largest in type IIB and smallest in type IIA. The lipid changes were dependent on lipid levels prior to treatment and on compliance with the medication regimen. When risk factors for CHD, including age, blood pressure, smoking and drinking habits, baseline lipid levels, and exercise and relative weight, were controlled by applying the Cox proportional hazards model, the changes in serum HDL and LDL cholesterol levels were both statistically significantly associated with the decline in CHD incidence within the gemfibrozil-treated group. The large decrease in serum triglyceride levels had relatively small effect on CHD incidence. Thus, the results of this study, together with earlier observations, suggest that both elevating HDL and lowering LDL cholesterol levels are effective in the primary prevention of CHD. (<i>JAMA</i>1988;260:641-651)
Recent Studies on Biomethylation and Demethylation of Toxic Elements
Authors: W. P. Ridley, L. Dizikes, A. Cheh, J. M. Wood
Journal: Environmental Health Perspectives (1977)

Methylcobalamin (methyl-B12) has been implicated in the biomethylation of the heavy metals (mercury, tin, platinum, gold, and thallium) as well as the metalloids (arsenic, selenium, tellurium and sulfur). In addition, methylcobalamin has been shown to react with lead, but the lead-alkyl product is unstable in water. Details of the kinetics and mechanisms for biomethylation of arsenic are presented, with special emphasis on synergistic reactions between metal and metalloids in different oxidation states. This study explains why synergistic, or antagonistic, processes can occur when one toxic element reacts in the presence of another. The relative importance of biomethylation reactions involving methylcobalamin will be compared to those reactions where S-adenosylmethionine is involved.
Physiology and Hygiene in Literary Colleges.
Journal: JAMA (1883)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ELECTRICAL EXECUTION.
Journal: JAMA (1890)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Journal of the Mount Sinai Hospital, New York
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BOOK REVIEWS
Authors: LOUIS M. WEINER
Journal: JNCI Journal of the National Cancer Institute (1993)

Journal Article BOOK REVIEWS Get access Gastrointestinal Cancer , Sidney J. Winawer , Robert C. Kurtz , eds., New York : Gower Med. Publ. , 1992 . 240 pp., illus. $99.50., ISBN 1-56375-020-1 LOUIS M. WEINER LOUIS M. WEINER Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 85, Issue 20, 20 October 1993, Page 1691, https://doi.org/10.1093/jnci/85.20.1691 Published: 20 October 1993
SACCHARATED VERSUS ALCOHOLIC EXTRACTS.
Authors: G. C. W.
Journal: JAMA (1885)

That many of the more popular quack medicines, tonics and bitters, are essentially alcoholic solutions, varying in percentage of alcohol from eight to about forty-five per cent, has been frequently demonstrated by analytical chemists. The list published by the State chemist of Rhode Island, giving the alcoholic strength of some thirty or forty of the leading bitters, is familiar to those who have but moderately pursued this line of investigation. It is not, however, so generally known that the two large classes of staple pharmaceutical preparations, viz. : Elixirs and fluid extracts, are<i>very rich</i>in alcohol, the fluid extracts generally containing over fifty per cent. Of these latter I wish now more particularly to speak. It is doubtless true in the case of those fluid extracts of the more powerful drugs, such as aconite, nux vomica, and the like, that on account of the smallness of the dose, the
International Agency for Research on Cancer Fellowships for Research Training in Cancer, 1988–89
Journal: JNCI Journal of the National Cancer Institute (1987)

Journal Article International Agency for Research on Cancer Fellowships for Research Training in Cancer, 1988–89 Get access JNCI: Journal of the National Cancer Institute, Volume 79, Issue 3, September 1987, Pages 609–610, https://doi.org/10.1093/jnci/79.3.609-d Published: 01 September 1987