tbuckley/cabot-search huggingface dataset:
Infusion of chlorothiazide in a patient with primary aldosteronism. Observations on potassium clearance
Authors: R. A. Schacht
Journal: JAMA (1967)

THE MECHANISM of action of intrauterine contraceptive devices (IUCDs) is still unknown. The reported tubal pregnancies in association with IUCDs make it evident that, in these cases, the device did not interfere with fertilization of the ovum in the fallopian tube. The purpose of this report is to record the first case of ovarian pregnancy, to our knowledge, in association with an IUCD. <h3>Report of a Case</h3> In June 1966, a 29-year-old, white, gravida 6 para 5 had a Lippes loop inserted. She did well until Jan 3, 1967, when her menses lasted for ten days. Bleeding began again on Jan 15 and persisted for ten days, and for eight more days beginning Jan 30. She continued to bleed almost daily until the time of her admission on Feb 23. Four weeks prior to admission, pain developed in the right lower quadrant of the abdomen, and continued until surgery. Examination
Abstract 18898: Long Non-coding RNA Fingerprint Regulated by Stretch and Cyclic Strain in Vascular Smooth Muscle Cells: Implications for Aortic Aneurysms
Authors: Laura-Eve Mantella, Crystal Kantores, Krishna K Singh, Adrian Quan, Mohammed Al-Omran, Robert P Jankov, Subodh Verma
Journal: Circulation (2015)

Background: Alterations in the characteristics of vascular smooth muscle cells (VSMCs), triggered largely by changes in mechanical stress, play a critical role in the pathophysiology of aneurysms and hypertension. Understanding the molecular determinants that link altered rheology to aberrant VSM remodeling may uncover novel approaches to treat vascular diseases. Long noncoding RNAs (lncRNAs) are a new class of noncoding RNA and emerging evidence suggest that they not only have a key role in the regulation of various biological processes but also represent a cellular hub for coordination of various cellular, inflammatory, and immune reactions involved in health and disease. In the present study, we report for the first time the lncRNA fingerprint regulated by cyclic strain in VSMCs. Methods and Results: VSMCs were plated on Bioflex plates, starved, and subjected to 20% elongation (1 Hz) for 24 h (Flexcell® FX4000™). Total RNA was extracted using TRIzol. LncRNAs and mRNAs were profiled with the Arraystar Human LncRNA Microarray V3.0. Of the 30,586 human lncRNAs screened, 580 were differentially expressed (p&lt;0.05) in stretched VSMCs. Amongst the 26,109 protein-coding transcripts evaluated, 26 of those differentially expressed were associated with 28 of the aforementioned differentially expressed lncRNAs (p&lt;0.05). Subsequent KEGG (Kyoto Encyclopedia of Genes and Genomes) analysis revealed that the differentially expressed mRNAs chemokine (C-X-C motif) ligand 1/2/3/5 (CXCL1/2/3/5), matrix metalloproteinase-3 (MMP-3), tumor necrosis factor, alpha-induced protein 3 (TNFAIP3) and vascular cell adhesion protein 1 (VCAM1), were largely associated with the tumor necrosis factor (TNF) signaling pathway, which has been previously associated with VSMC stretch-response. Further Gene Ontology analysis indicated that the differentially expressed mRNAs were associated with cell differentiation, stress response, response to external stimuli and cell migration. Conclusions: We provide the first global fingerprint of cyclic strain regulated lncRNAs in VSMC cells. This information provides novel insights into the regulatory switches governing aberrant VSMC remodeling, which may have importance in the pathogenesis of aneurysms and hypertension.
Abstract 2313: DDR1 receptor kinase pathway as an emerging target in cancer therapeutics
Authors: Hyung-Gu Kim, Anna Mandinova, So Young Hwang, Stuart L. Schreiber, Sam W. Lee
Journal: Cancer Research (2011)

Abstract We have identified a novel p53 pro-survival signaling pathway involving up-regulation/activation of a p53 target gene DDR1 and its down-stream signaling, which can influence the balance between cell death and survival in a p53 dependent response. Unlike other p53 target genes that function as either cell cycle inhibitors or apoptosis-promoters, DDR1 kinase promotes cell survival by counteracting p53-mediated cell death/apoptosis. Furthermore, accumulating evidence suggest that aberrant signaling through DDR1 kinase is closely associated with various steps of tumorigenesis and carcinogenesis, although little is known about the molecular mechanism(s) underlying the role of DDR1 in cancer. We have identified TK0019 as a DDR1 tyrosine kinase inhibitor via the target-based small molecule array screening. TK0019 specifically targets DDR1 kinase and its novel targets involved in EMT (Epithelial-Mesenchymal transition) pathway such as Slug, AKT and vimentin, which is known to play a major role in tumor progression and metastasis development. In addition, TK0019 suppressed the activation of AKT prosurvival protein and of essential EMT pathway proteins involved in tumor migration/invasion. DDR1 kinase is highly expressed in a variety of human cancer and occasionally mutated in lung cancer and leukemia. TK0019 binds directly to N-terminal part (extracellular region of the receptor) of DDR1 protein and specifically inhibits DDR1 kinase activation in response to its ligand. TK0019 demonstrated antiproliferative activity against a range of DDR1-overexpressing cancer cell lines without high cytotoxicity in normal cells. TK0019 also exhibited the potent anti-growth properties even in EGFR targeted (erlotinib and gefitinib) drug-resistant cancer cells. TK0019 potently inhibited spontaneous formed breast cancer tumors and their associated metastasis in mice with no apparent adverse effects on normal organs. More particularly, the invention features a novel use of TK0019 for effective treatment of the variety human cancers by inhibiting tumor migration/invasion via the inactivation of EMT pathway. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2313. doi:10.1158/1538-7445.AM2011-2313
Phase I results of the randomized, placebo controlled, phase I/II study of the novel oral c-Met inhibitor, ARQ 197, irinotecan (CPT-11), and cetuximab (C) in patients (pts) with wild-type (WT) KRAS metastatic colorectal cancer (mCRC) who have received front-line systemic therapy.
Authors: C. Eng, J. C. Bendell, A. Bessudo, N. Y. Gabrail, J. Diamond, A. U. Pande, I. Gorbatchevsky
Journal: Journal of Clinical Oncology (2011)

527 Background: ARQ 197 selectively inhibits the c-Met receptor tyrosine kinase (RTK), which has been implicated in tumor cell migration, invasion, proliferation, and angiogenesis. CPT-11 plus C is a standard of care for CPT-11-refractory mCRC pts with WT KRAS tumors. Resistance to C has been associated with activation of alternative RTK pathways including c-Met. We hypothesize that adding ARQ 197 to CPT-11 plus C may decrease resistance to C therapy and improve pt outcomes. Methods: The primary objectives of phase I were to evaluate safety and tolerability of ARQ 197 administered in combination with CPT-11 plus C, and to define a recommended phase II dose (RPTD). Pts with surgically unresectable locally advanced or mCRC who received at least 1 prior line of chemotherapy, KRAS WT and ECOG performance status &lt; 2 were eligible. Cohorts of 3 pts each were treated with CPT-11 (180 mg/m 2 ) and C (500 mg/m 2 ) every 2 weeks along with escalating doses of ARQ 197 (120, 240, 360 mg) PO BID. Blood and tissue were collected for PK, biomarker, and other analyses. If no DLTs were observed during the first 28-day cycle in 3 pts treated in cohort 3, 360 mg BID would be defined as the RPTD. Responses were assessed every 8 weeks per RECIST v1.1. Results: Nine pts were treated in 3 cohorts. Median age: 53 yrs (range 30-77); ECOG PS 0/1: 4/5; median prior therapies: 2 (range 1-4). No DLTs were observed. The RPTD for ARQ 197 was 360 mg BID. To date, two pts have discontinued (1 disease progression and 1 withdrew consent after achieving complete response) and 7 pts remain on study. The reported grade 3/4 adverse events were: neutropenia (3/4: 1/1), and one case each of grade 3 fatigue, leucopenia, acneiform rash, vomiting, anemia and syncope. Preliminary efficacy data in 9 evaluable pts include 1 CR (after 4 cycles), 2 PR (after 2 cycles), 5 SD, and 1 PD as best response. Conclusions: The combination of ARQ 197 and CPT-11 plus C was well tolerated with encouraging preliminary antitumor activity. The RPTD for ARQ 197 was 360 mg BID. The randomized phase II portion of the study continues accrual. [Table: see text]
State Boards of Registration
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Incidence, Clinical Features, and Outcome of AllTrans-Retinoic Acid Syndrome in 413 Cases of Newly Diagnosed Acute Promyelocytic Leukemia
Authors: S. De Botton, H. Dombret, M. Sanz, J. San Miguel, D. Caillot, R. Zittoun, M. Gardembas, A. Stamatoulas, E. Condé, A. Guerci, C. Gardin, K. Geiser, D. Cony Makhoul, O. Reman, J. de la Serna, F. Lefrere, C. Chomienne, C. Chastang, L. Degos, P. Fenaux, the European APL Group
Journal: Blood (1998)
New Surgical and Pathological Society.
Authors: None X.
Journal: JAMA (1891)

Getting the Hospital and Ambulance Service in Readiness for the Meeting of the Grand Army of the Republic. <h3>To the Editor:</h3> —The profession in Detroit are at present interested in making arrangements for the medical and surgical care of the veteran soldiers who meet in this city early in August. A committee composed of representative practitioners, under the chairmanship of Dr. E. L. Shurly, have the work in charge. They have divided the city into ambulance districts, established medical relief stations at intervals along the line of march, and gotten the hospitals into special condition for the reception of the old soldiers who may happen to be taken sick or be injured while here. The demands of irritable bladders and prostates are to be particularly looked after by the erection of a large number of latrines where they will be most accessible. It is said that in some cities which
BOOK REVIEWS
Authors: D. SIDRANSKY
Journal: JNCI Journal of the National Cancer Institute (1991)

BOOK REVIEWS Oncogenes and the Molecular Origins of Cancer . Robert A. Weinberg , ed. Cold Harbor, N.Y. : Cold Spring Harbor Laboratory Press , 1989 , 367 pp, $97. DAVID SIDRANSKY DAVID SIDRANSKY Johns Hopkins Oncology Center424 N. Bond St. Baltimore, MD 21231 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 11, 5 June 1991, Page 785, https://doi.org/10.1093/jnci/83.11.785 Published: 05 June 1991
Quality of care in rural hospitals
Authors: R. Buck
Journal: JAMA (1993)

<h3>In Reply.</h3> —We are happy to clarify our conclusions. Technical quality of care is one aspect of hospital performance, and small rural hospitals can provide basic services in a convenient, friendly setting. In addition, despite their lower occupancy, smaller hospitals provided care at lower cost than did larger urban hospitals.<sup>1</sup>One might also question how much should be spent on aggressive treatment for these very sick patients. However, our study showed that these potential benefits of rural hospitals have a cost in terms of both reduced technical quality and increased death rates for patients with severe disease. Mr Behringer's letter notes that these problems are being addressed. We hope so. Dr Rosenblatt's references document that without access to hospital care, people's health suffers. However, many small hospitals struggle on despite low occupancy caused by competition with other nearby hospitals. Some of these hospitals could be transformed into other health
Effects of Fluorocarbons, Chlorinated Solvents, and Inosine on the Cardiopulmonary System
Authors: Domingo M. Aviado
Journal: Environmental Health Perspectives (1978)

The effects of fluorocarbons and chlorinated solvents on the cardiopulmonary system are reviewed. The new information, not hitherto reported, relates to the antagonistic action of inosine, a naturally occurring nucleoside formed in the body by deamination of adenosine. The effect of inosine on methylene chloride toxicity was investigated in open chest dogs anesthetized with pentobarbital sodium. Methylene chloride (5% in air or 50,000 ppm) elicited a decrease of ventricular contractility represented by the diminished left ventricular (dp/dt)max and myocardial contractile force measured directly with a Walton-Brodie strain gauge arch. Coronary blood flow decreased slightly after exposure to methylene chloride. Arterial blood pressure and heart rate did not change. The negative inotropic effect of methylene chloride was reversed or prevented to a substantial extent by intravenous infusion of inosine (5 mg/kg-min). The effect of the latter compound was also characterized by significant coronary vasodilation. It was shown by the experiments that the cardiostimulatory action of inosine was associated with improved hypoxic adaptability of the coronary blood vessels. In contrast, the effect of catecholamines (epinephrine and isoproterenol) was not accompanied by such a beneficial coronary vascular effect. On the basis of these results, the conclusion has been arrived at that inosine might be recommended as a useful antidote in methylene chloride poisoning in particular, and of poisoning by chlorinated solvents and fluorocarbons in general.
Task force to make recommendations for adolescents in terms of suicide risk
Authors: K. Simmons
Journal: JAMA (1987)

TWO YEARS AGO, the Secretary of Health and Human Services convened a task force on youth suicide to address the issues of risk factors, intervention, and prevention (<i>JAMA</i>1985;254:1286). The task force is expected to make its recommendations this summer. According to Mark Rosenberg, MD, chair of the task force's work group on strategies and recommendations and assistant director for science, Division of Injury Epidemiology and Control, Centers for Disease Control, Atlanta, "We can track the number of suicides better now, and we have some understanding of the basic pattern, but we still need to develop an effective intervention program." What can physicians do to intervene? The experts who were interviewed for this article had several suggestions. Paul C. Holinger, MD, MPH, associate professor of psychiatry at Rush-Presbyterian—St Luke's Medical Center in Chicago, believes a knowledge of suicide risk is essential for internists and primary care physicians. "Just as they're
Cancer
Authors: Grantley W. Taylor
Journal: New England Journal of Medicine (1947)

A POSTWAR survey of practice and theory in relation to cancer problems shows little fundamental change in comparison with the prewar years, although in some fields there have been modifications and shifts in emphasis. This review can make no pretense of being complete, but it seems desirable to comment on certain aspects of the problem. Carcinoma of the Mouth There appears to be an increasingly accurate discrimination regarding the respective fields of radiation and surgery in the treatment of primary intraoral carcinoma.1 , 2 The former division into separate camps, with exclusive use of radiation in some clinics and exclusive use of . . .
The Essentials of Chemical Physiology for the Use of Students.
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Communication Between Physicians and Older Women With Localized Breast Cancer: Implications for Treatment and Patient Satisfaction
Authors: Wenchi Liang, Caroline B. Burnett, Julia H. Rowland, Neal J. Meropol, Lynne Eggert, Yi-Ting Hwang, Rebecca A. Silliman, Jane C. Weeks, Jeanne S. Mandelblatt
Journal: Journal of Clinical Oncology (2002)

PURPOSE: To identify factors associated with patient-physician communication and to examine the impact of communication on patients’ perception of having a treatment choice, actual treatment received, and satisfaction with care among older breast cancer patients. MATERIALS AND METHODS: Data were collected from 613 pairs of surgeons and their older (≥ 67 years) patients diagnosed with localized breast cancer. Measures of patients’ self-reported communication included physician- and patient-initiated communication and the number of treatment options discussed. Logistic regression analyses were conducted to examine the relationships between communication and outcomes. RESULTS: Patients who reported that their surgeons mentioned more treatment options were 2.21 times (95% confidence interval [CI], 1.62 to 3.01) more likely to report being given a treatment choice, and 1.33 times (95% CI, 1.02 to 1.73) more likely to get breast-conserving surgery with radiation than other types of treatment. Surgeons who were trained in surgical oncology, or who treated a high volume of breast cancer patients (≥ 75% of practice), were more likely to initiate communication with patients (odds ratio [OR] = 1.62; 95% CI, 1.02 to 2.56; and OR = 1.68; 95% CI, 1.01 to 2.76, respectively). A high degree of physician-initiated communication, in turn, was associated with patients’ perception of having a treatment choice (OR = 2.46; 95% CI, 1.29 to 4.70), and satisfaction with breast cancer care (OR = 2.13; 95% CI, 1.17 to 3.85) in the 3 to 6 months after surgery. CONCLUSION: Greater patient-physician communication was associated with a sense of choice, actual treatment, and satisfaction with care. Technical information and caring components of communication impacted outcomes differently. Thus, the quality of cancer care for older breast cancer patients may be improved through interventions that improve communication within the physician-patient dyad.
Long non-coding RNA ANRIL is upregulated in hepatocellular carcinoma and regulates cell proliferation by epigenetic silencing of KLF2
Authors: Ming-de Huang, Wen-ming Chen, Fu-zhen Qi, Rui Xia, Ming Sun, Tong-peng Xu, Li Yin, Er-bao Zhang, Wei De, Yong-qian Shu
Journal: Journal of Hematology & Oncology (2015)

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death, especially in China. And the mechanism of its progression remains poorly understood. Growing evidence indicates that long non-coding RNAs (lncRNAs) are found to be dysregulated in many cancers, including HCC. CDKN2B antisense RNA1 (ANRIL), a lncRNA, coclustered mainly with p14/ARF has been reported to be dysregulated in gastric cancer, esophageal squamous cell carcinoma, and lung cancer. However, its clinical significance and potential role in HCC is still not documented.
Error in Figure
Journal: JAMA Neurology (2020)

Matthias Brendel, MD, MHBA; Henryk Barthel, MD, PhD; Thilo van Eimeren, MD; Ken Marek, MD; Leonie Beyer, MD; Mengmeng Song; Carla Palleis, MD; Mona Gehmeyr; Urban Fietzek, MD; Gesine Respondek, MD; Julia Sauerbeck; Alexander Nitschmann; Christian Zach, PhD; Jochen Hammes, MD; Michael T. Barbe, MD; Oezguer Onur, MD; Frank Jessen, MD; Dorothee Saur, MD; Matthias L. Schroeter, MD, PhD, MA; Jost-Julian Rumpf, MD; Michael Rullmann, PhD; Andreas Schildan, PhD; Marianne Patt, PhD; Bernd Neumaier, PhD; Olivier Barret, MD; Jennifer Madonia, MS; David S. Russell, MD, PhD; Andrew Stephens, MD, PhD; Sigrun Roeber, MD; Jochen Herms, MD; Kai Bötzel, MD; Joseph Classen, MD; Peter Bartenstein, MD; Victor Villemagne, MD, PhD; Johannes Levin, MD; Günter U. Höglinger, MD; Alexander Drzezga, MD; John Seibyl, MD; Osama Sabri, MD, PhD
A RURAL EPIDEMIC OUTBREAK OF TUBERCULOSIS.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Book: Bodies
Authors: N. Chohan
Journal: BMJ (2002)

Jed Mercurio ![Graphic][1]</img>Jonathan Cape, £10.99, pp 359 ISBN 0 224 06197 6 Rating:![Graphic][2]</img>![Graphic][3]</img>![Graphic][4]</img> Jed Mercurio is a former senior house officer (SHO), better known for having written the BBC medical drama Cardiac Arrest under the pseudonym John MacUre. Bodies is his first novel. Written in the first person, it tracks the journey of a new graduate, fresh out of medical school, through his preregistration year and eventually into his SHO jobs at a large city teaching hospital. Life … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif [4]: /embed/inline-graphic-4.gif