tbuckley/cabot-search huggingface dataset:
Trekking in Nepal: Safety After Coronary Artery Bypass
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Foreword
Authors: Giorgio Ciprandi
Journal: Allergy (2004)

It is now clear that only about 50% of patients suffering from rhinitis have a clinically relevant allergic disease, while the remaining 50% of patients do not have a defined allergic etiology. This latter group of patients are classified as suffering from “non-allergic rhinitis”, which is characterized by sporadic or spontaneous perennial symptoms of rhinitis that are not associated with IgE-mediated immunopathologic events. This general term encompasses several entities; for example vasomotor rhinitis (which has also been referred to as non-allergic noninfectious perennial rhinitis, NANIPER), non-allergic infectious perennial rhinitis, occupational rhinitis, hormonal rhinitis, drug-induced rhinitis, non-allergic rhinitis with eosinophilia syndrome (NARES), and “others” (1, 2). Patients suffering from vasomotor rhinitis, in particular, form a substantially large group of individuals with non-allergic rhinitis, and pose a real challenge in every day practice, since their underlying pathophysiology is largely unknown, specific diagnostic tests do not exist, and treatment options are often very limited and not satisfactory. In an attempt to address some of the major issues surrounding vasomotor rhinitis, a satellite symposium entitled “Rhinitis may not be just allergic…”, organized and sponsored by Viatris, was held at the European Academy of Allergology and Clinical Immunology (EAACI) Annual Congress in Naples, 3rd June 2002. The symposium focused on gaining a better understanding of vasomotor rhinitis, the putative underlying mechanisms, and current treatment of this condition. The articles presented in this supplement issue summarize the presentations by an international panel of experts, who addressed the various aspects of the disease.
THOMAS WILLIS (1621-1675)
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Antibodies Against the Erythroferrone N-Terminal Domain Prevent Hepcidin Suppression and Ameliorate Murine Thalassemia
Authors: Joao Arezes, Niall Foy, Susan Benard, Anagha Sawant, May S Tam, Zachary Maben, Kirsty McHugh, Doris Quinkert, Andrew E Armitage, Sant-Rayn Pasricha, Pei-Jin Lim, Joe Frost, Edward LaVallie, Orla Cunningham, Matthew Lambert, Debra D Pittman, John E. Murphy, Simon J Draper, Reema Jasuja, Alexander Drakesmith
Journal: Blood (2019)
Phase I trial of cetuximab, intensity modulated radiotherapy (IMRT), and ipilimumab in previously untreated, locally advanced head and neck squamous cell carcinoma (PULA HNSCC)
Authors: R.L. Ferris, D.A. Clump, J. Ohr, W. Gooding, S. Kim, B.J. Karlovits, U. Duvvuri, J.T. Johnson, D. Petro, D.E. Heron, J. Bauman
Journal: Annals of Oncology (2017)
Proposed changes in Britain's health service stir varied reactions, widespread controversy
Authors: J. F. Henahan
Journal: JAMA (1989)

BY ANY MEASURE, the proposed National Health Service changes are massive and have become the subject of widespread controversy among British physicians, nurses, patients, and all shades of political opinion. A British Medical Association spokeswoman says that the association, which represents about three quarters of the United Kingdom's 100 000 physicians, has strong reservations about many points of the proposed changes. Among the proposed changes are the following: Most pertinent to the Guy's Hospital management scheme, 320 of England's 2000 hospitals will be given the opportunity to "opt out" of health authority control (the National Health Service) and operate mainly on a freemarket basis. They will be able to set their own salary schedules, while receiving partial payment for their operations from the National Health Service, from contracts with general practitioners for treatment, and from other hospital trusts. . One hundred new consultants. cialist hospital physicians) will be appointed within the
Source apparently as important as content of some genes
Authors: B. Merz
Journal: JAMA (1989)

WHETHER MOM OR DAD was responsible for a patient's blue eyes may not matter, but the identity of the parent who passed on a defective gene may drastically affect the course of the resultant disease. That was the word from investigators who reported on the effects of genetic imprinting at the recent annual short course in medical and mammalian genetics in Bar Harbor, Maine. The course was sponsored by Johns Hopkins University in Baltimore, Md, and the Jackson Laboratory in Bar Harbor. Genetic imprinting is defined as "the differential modification of parental contributions to the zygote, resulting in differential expression of information inherited from those parents." In other words, a gene inherited from the mother may be expressed differently from an identical gene inherited from the father. The imprinting paradigm is providing an explanation for many heretofore unexplained phenomena seen in both laboratory experiments and in clinical genetics. Said Judith
TATTOW'D OR MARKED IN THE FACE"
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CHEMICAL, CLINICAL, AND IMMUNOLOGICAL STUDIES ON THE PRODUCTS OF HUMAN PLASMA FRACTIONATION. XXXI. THE USE OF SALT-POOR CONCENTRATED HUMAN SERUM ALBUMIN SOLUTION IN THE TREATMENT OF HEPATIC CIRRHOSIS 12
Authors: G. W. Thorn, S. H. Armstrong, V. D. Davenport
Journal: Journal of Clinical Investigation (1946)

Albumin level (grams per cent) DiscrepancyPatient Howe Uncorrected Howe minus Howe electrophoresis electrophoresis J
PRECIPITATION TESTS IN THE DIAGNOSIS OF SYPHILIS
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Environmental Sensitivities: Prevalence of Major Symptoms in a Referral Center: The Nova Scotia Environmental Sensitivities Research Center Study
Authors: Michel R. Joffres, Tim Williams, Brenda Sabo, Roy A. Fox
Journal: Environmental Health Perspectives (2001)

Although the phenomenon of environmental sensitivities (ES) has no clear etiology nor well-accepted pathophysiology, affected individuals experience symptoms that cause varying levels of dysfunction. Through a dedicated, government-funded research and treatment center, a detailed questionnaire covering 217 symptoms in 13 systems was mailed in 1997-1998 to 812 individuals referred to the center by physicians. A total of 385 (47%) questionnaires were returned, and data were analyzed on 351 individuals. Participants tended to be women (80%), middle-aged individuals (37% age 40-49 years), and those in higher educational groups (28% completed university), but there was wide variation in demographic variables. General symptoms such as difficulty concentrating, fatigue, forgetfulness, and irritability dominated the overall prevalence of symptoms since the start of their illness. Those related to irritation such as sneezing, itchy or burning eyes, and hoarseness or loss of voice were more common after exposure to environmental irritants. Ranking of symptoms using severity scores was consistent between men and women. Overall scores were higher in women, in participants who were separated or divorced, and in low-income groups. The type and consistency of symptoms experienced after exposure to triggering substances may not fit a purely psychogenic theory.
Endoscopy
Authors: Edward B. Benedict
Journal: New England Journal of Medicine (1946)

ALTHOUGH endoscopy may seem to be a narrow specialty, many of the most interesting diagnostic problems in the hospital eventually come to some form of endoscopic examination. As will be seen in the following review, these include many pulmonary problems that may need bronchoscopic study, gastrointestinal problems, which often require a direct inspection by esophagoscopy or gastroscopy, and various abdominal conditions, such as hepatomegaly, unexplained ascites and abdominal or pelvic masses, which may be satisfactorily studied by peritoneoscopy.Bronchoscopy Congenital Anomalies Ferguson and Neuhauser1 report 5 cases of agenesis of the lung diagnosed during life by bronchoscopy, followed by iodized . . .
Abstract 4312: Multiplex parallel perturbation of Akt and MAPk signaling cascades
Authors: Andrew R. Wagner, Megan Newby, Kary Oakleaf
Journal: Cancer Research (2019)

Abstract PI3K/Akt and MAPk signal transduction pathways are frequently dysregulated in human cancers. Previous work described the molecular basis of pro-survival signals mediated by Akt and MAPk. Mutation in and alteration of these pathways lead to tumorigenesis. However, signal propagation varies across cell type and precise signaling kinetics is less well characterized. The goal of this study is to profile the functional state of the PI3k/Akt and MAPk signaling circuits by coupling cell viability to antibody microarray and immunofluorescence. Simultaneous detection of Akt and MAPk signaling nodes can characterize signaling parameters that correlate to localization patterns across cell type and drug treatment conditions. To examine how signal propagation varied between cell lines, staurosporine was utilized to broadly inhibit protein kinase activity in a cervical cancer cell line, HeLa, and an osteosarcoma cell line, U2-OS, as model systems. To investigate signaling pathways, each cell line was treated and analyzed in parallel by forward phase phospho-specific antibody microarray panels and high content analysis of immunofluorescent staining. Staurosporine inhibited cell proliferation in a time and concentration dependent manner in both cell lines. U2-OS cells had a higher IC50 compared to HeLa cells indicating markedly different signaling parameters between the two models. Our observations suggest detecting cell type specific signaling kinetics can be used as a framework to predict cell sensitivity to specific inhibitors and be used to monitor drug resistance. Note: This abstract was not presented at the meeting. Citation Format: Andrew R. Wagner, Megan Newby, Kary Oakleaf. Multiplex parallel perturbation of Akt and MAPk signaling cascades [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4312.
Occult splenic rupture
Authors: R. P. Fischer
Journal: JAMA (1977)

We appreciate the recent rethinking of the incidence of delayed rupture of the spleen through the routine use of paracentesis. Despite the reduced incidence mentioned in Dr Fischer's letter, the mechanism by which a true delayed rupture occurs is a valid one. The dilemma of an occult rupture stems from the fact that hemorrhage is tamponaded and contained by adjacent stomach, bowel, and omentum—preventing free intraperitoneal bleeding; thus, it is not amenable to diagnosis by paracentesis.
Questions and Answers
Journal: JAMA (1981)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Book Review Influence of a Public Health Program on a Rural Community: Fifteen years in Rutherford County, Tennessee, 1924–1938 . By W. Frank Walker, Dr.P.H., and Carolina R. Randolph. 12°, paper, 106 pp., with 46 tables and 6 charts. New York: Commonwealth Fund, 1940. 25 cents.
Journal: New England Journal of Medicine (1941)
Recent trends in the identification and treatment of high blood cholesterol by physicians. Progress and missed opportunities
Authors: W. H. Giles
Journal: JAMA (1993)

<h3>Objective.</h3> —To investigate recent trends in the percentage and characteristics of patients being treated by a physician for high blood cholesterol (HBC) and to assess missed clinical opportunities to screen for HBC. <h3>Design, Setting, Participants.</h3> —Telephone interviews of 154735 adults in 37 states that participated in the Behavioral Risk Factor Surveillance System during 1988-1990 to assess trends in the percentage of patients treated for HBC by a physician. An opportunity was considered missed if a person did not report being screened for HBC despite seeing a physician for preventive care in the last 2 years. <h3>Results.</h3> —Between the first quarter of 1988 and the last quarter of 1990, the percentage of persons treated by a physician for HBC increased from 7.6% to 11.7% (<i>P</i>&lt;.001). However, since an estimated 36% of US adults need treatment for HBC, fewer than one third of persons who need treatment are receiving it. Persons with two or more cardiac risk factors were more likely to be treated, while men, blacks, persons in lower socioeconomic groups, and persons between 20 and 34 years of age were less likely to be treated. Among the 126571 persons who had seen a physician for preventive care within the last 2 years, missed opportunities to screen for HBC were most common among persons aged 20 through 34 years (59%) and among women who had seen obstetricians/gynecologists for preventive care (43%). <h3>Conclusions.</h3> —Fewer than one third of persons who need treatment for HBC as estimated by data from the second National Health and Nutrition and Nutrition Examination Survey are receiving treatment. Better use of clinical opportunities to screen for HBC could substantially accelerate the progress in identifying persons, young adults in particular, who are likely to benefit from cholesterol reduction. (<i>JAMA</i>. 1993;269:1133-1138)
Application of metabolic data to the evaluation of drugs
Authors: D. L. Azarnoff
Journal: JAMA (1970)

Five percent of hospital admissions is the consequence of adverse drug reactions. Many are preventable and related, in some manner, to the metabolism of the drug (induction or inhibition of drug metabolizing enzymes, pharmacogenetic abnormalities in the patient, poorly developed enzyme activities in infants). It is no longer possible to prescribe drugs rationally on the basis of a memorized schedule of dosages and contraindications since the same dose administered to different individuals or the same individual at different times may achieve a therapeutic, a toxic, or an inadequate effect. The mechanisms responsible for the variations are now understood, at least in part, and are related to the absorption, distribution, excretion, metabolism, and interactions of the drug. An excellent correlation between plasma level and pharmacological effect of some drugs has been observed in human studies.<sup>1</sup>However, individual differences in the rates of metabolism may account for a thirtyfold variation in
Induction of SOS Functions in Escherichia coli and Biosynthesis of Nitrosamine in Rabbits by Nitrogen Dioxide
Authors: Hiroaki Kosaka, Mitsuro Uozumi, Taichi Nakajima
Journal: Environmental Health Perspectives (1987)

Nitrogen dioxide induced SOS functions in Salmonella typhimurium and Escherichia coli K-12 and was mutagenic in Escherichia coli WP2. When a rabbit was administered aminopyrine intravenously and administered nitrogen dioxide by inhalation, N-nitrosodimethylamine was detected in its blood. Analysis was conducted with 15N-nitrosodimethylamine as an internal standard by a combination of capillary gas chromatography and mass spectrometry. Accompanying administration of cystamine increased the blood concentration of N-nitrosodimethylamine in the rabbit, suggesting inhibition of its metabolism. Concurrent sulfur trioxide inhalation increased N-nitrosodimethylamine formation in the rabbit.
Unproven Methods of Cancer Treatment: Nichols Escharotic Method
Journal: CA A Cancer Journal for Clinicians (1968)

After careful study of the literature and other information available to it, the American Cancer Society has not found evidence that treatment with the Nichols Escharotic Method results in objective benefit in the treatment of cancer.The following is a summary of infor mation on the Nichols Escharotic Method in the American Cancer Society files:The Dr. Nichols Sanatorium, using the Nichols Escharotic Method, was founded by Perry Lewis Nichols, M.D., at Savan nah, Missouri, in 1914.The Sanatorium closed in 1957.Shortly thereafter, reports were received that two osteopaths form erly employed at the Sanatorium, Drs.Robert F. Sutter and L
Rhabdomyolysis and myoglobinuria. Association with hypokalemia of renal tubular acidosis
Authors: D. S. Campion
Journal: JAMA (1972)

A 44-year-old woman had severe hyperchloremic acidosis and hypokalemia. She had paralysis, muscle tenderness, and myoglobinuria. There was no history of previous muscle abnormality. In this case, the rhabdomyolysis appeared to be the result of potassium deficiency without concurrent drug therapy.
In vivo and in vitro expression of defective hepatitis B virus particles generated by spliced hepatitis B virus RNA*1
Authors: O ROSMORDUC
Journal: Hepatology (1995)

The mechanisms involved in hepatitis B virus (HBV) persistence are still poorly understood. We have previously shown that the encapsidation of the singly spliced 2.2 kb-HBV RNA leads to the secretion of circulating HBV defective particles in patients with chronic hepatitis. We have now investigated the presence of the HBV defective particles in sera from patients with acute and chronic hepatitis, using polymerase chain reaction. These defective particles were detected in a larger amount in sera of patients with acute hepatitis that progressed to chronic hepatitis, or had already developed chronic hepatitis, as compared with those who recovered from acute hepatitis (the increase was estimated to be an average of 50-fold). In addition, we showed that the presence of these defective HBV particles is closely associated with the chronic course of hepatitis B virus infection and with viral multiplication. We also analyzed viral RNAs and proteins synthetized after in vitro transfection of Huh7 cell line with the corresponding defective hepatitis B virus DNA molecule. We showed that expression of the defective hepatitis B virus DNA alone leads to a marked intracellular accumulation of the major core protein (HBcAg) and to an increased secretion of hepatitis B e antigen (HBeAg). These observations may be consistent with a role of these defective hepatitis B virus (HBV) particles in viral persistence.