tbuckley/cabot-search huggingface dataset:
Civilian physician contribution to the active military
Authors: R. L. Bradley
Journal: JAMA (1977)

The civilian physician contribution to the Armed Forces of the United States has seldom been heralded in the historic chronology of this country and even less in its military annals. Yet at no time in peace or war has the regular military establishment been staffed to meet its medical requirements without aid from its civilian counterpart (Figure). In our War for Independence, essentially all our forces, support and combat, emerged from the civil ranks. The United States, born in war and involved in three major conflicts and innumerable smaller ones, remains distrustful of a strong military, yet its ability to mobilize in time of war is equaled only by its haste to demobilize when peace is secured. Our peacetime military has been pared in years past to a bare housekeeping strength, and the active medical corps has shared the severity of force reduction. Physicians for the military cannot be produced
The question of a helminthic cause of preeclampsia
Authors: F. O. Richards
Journal: JAMA (1983)

Two recent reports have suggested that wormlike structures characteristic of helminths are associated with preeclampsia. We identified these vermiform structures in toluidine blue O-stained venous blood smears from four women with preeclampsia, cord blood taken at delivery of three of their neonates, and venous blood from five control subjects without preeclampsia and from five healthy beagle dogs. The structures, which had diameters between 30 and 670 μm, could not be concentrated by passing the blood through a 12-μm filter, yet they could be demonstrated in stained smears prepared from blood that had been filtered. We conclude that these structures are not helminths; they are most likely artifacts of staining. (<i>JAMA</i>1983;250:2970-2972)
Long-Term Hematopoietic Damage: Concepts, Approaches, and Results Relevant to the Study of Environmental Toxins
Authors: Nydia G. Testa, Thomas M. Dexter
Journal: Environmental Health Perspectives (1989)

The hematopoietic tissue is one of the prime examples of hierarchical tissues, where mature cells with a limited life span are continually replaced as a result of proliferation and differentiation from stem and progenitor cells. In the bone marrow, these processes are controlled by growth factors and by cell to cell interactions, the latter being specially important for the regulation of the stem-cell population. In the study of long-term hematopoietic damage, we have to distinguish between deleterious effects of the environmental toxins on the stem and progenitor cells, and on the stromal bone marrow cells which are part of the regulatory hematopoietic microenvironment. In some experimental situations, the function of the tissue may be subnormal, not because of stem cell damage (which may also be present), but because of damage to regulatory environmental populations. Because of the high degree of organization of the hematopoietic tissue (not immediately obvious from histological sections), the heterogeneity of the stromal cell populations, and their different capacities to regenerate after cytotoxic insult, the stromal damage is likely to be heterogeneous and would tend to be expressed functionally at later times than acute hematopoietic injury. While microenvironmental damage may be of importance in the induction of hematopoietic failure, the primary target in leukemogenesis is likely to be the stem cell. However, experimental data support the concept that regulatory microenvironmental influences may hinder or favor the development of leukemia.
Synopsis of Midwifery.
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
What's new in the other general journals
Authors: Alison Tonks
Journal: BMJ (2005)

The American College of Cardiology and the American Heart Association both recommend early mechanical revascularisation (usually percutaneous) for people aged less than 75 who develop cardiogenic shock after a heart attack. But about half of eligible patients in the United States were still missing out five years after the recommendations were published. A study based on data from a national register of patients with heart attack shows that in 2004, only 54.4% of patients with heart attack and cardiogenic shock had a percutaneous coronary intervention, although a further 3.2% had an immediate coronary artery bypass operation. Credit: JAMA The National Registry of Myocardial Infarction, which is sponsored by the drugs industry, includes 293 633 US patients who had a heart attack with ST segment elevation between 1995 and 2004 and who presented to a hospital with revascularisation capability. Of these patients, 8.6% (25 311) had cardiogenic shock or developed it during their admission. Although their chances of percutaneous revascularisation have increased steadily from the 27.4% recorded in 1995, the recommendations had no measurable impact on the upward trend when they were published in 1999. Although these high risk patients are less likely to die of cardiogenic shock now than they were 10 years ago (47.9% v 60.3%), these data show there is still plenty of room for improvement. In this study, as in others, better survival was clearly and independently associated with early revascularisation. JAMA 2005;294: 448–54 [OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] Between 1998 and 2002, 2593 children and adults become ill after exposure to pesticides in and around US schools. That's an incidence of 7.4 per million schoolchildren and 27.3 per million adult employees. Most of the illnesses were mild (2315, 89%), but 275 people (11%) were ill enough to need treatment, and in three people (0.1%) the illness was life threatening. Two thirds of the reported … [1]: {openurl}?query=rft.jtitle%253DJAMA%26rft.stitle%253DJAMA%26rft.issn%253D0002-9955%26rft.aulast%253DBabaev%26rft.auinit1%253DA.%26rft.volume%253D294%26rft.issue%253D4%26rft.spage%253D448%26rft.epage%253D454%26rft.atitle%253DTrends%2Bin%2BManagement%2Band%2BOutcomes%2Bof%2BPatients%2BWith%2BAcute%2BMyocardial%2BInfarction%2BComplicated%2Bby%2BCardiogenic%2BShock%26rft_id%253Dinfo%253Adoi%252F10.1001%252Fjama.294.4.448%26rft_id%253Dinfo%253Apmid%252F16046651%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1001/jama.294.4.448&link_type=DOI [3]: /lookup/external-ref?access_num=16046651&link_type=MED&atom=%2Fbmj%2F331%2F7512%2F311.atom [4]: /lookup/external-ref?access_num=000230733400019&link_type=ISI
Availability of Streptomycin and Para-Aminosalicylic Acid—United States
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Deliberate Digitalis Intoxication: Comparison of the Toxic Effects of Four Glycoside Preparations
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction to: The lncRNA UCA1 promotes proliferation, migration, immune escape and inhibits apoptosis in gastric cancer by sponging anti-tumor miRNAs
Authors: Chao-Jie Wang, Chun-Chao Zhu, Jia Xu, Ming Wang, Wen-Yi Zhao, Qiang Liu, Gang Zhao, Zi-Zhen Zhang
Journal: Molecular Cancer (2019)

Following publication of the original article [1], authors reported Pro. Gang Zhao has to be considered as another corresponding author, according to his important contribution.
A Cyclopedia of Practical Medicine and Surgery.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Estrogen use and all-cause mortality. Preliminary results from the Lipid Research Clinics Program Follow-Up Study
Authors: T. L. Bush
Journal: JAMA (1983)

The association of exogenous estrogen use and hysterectomy status with all-cause mortality was examined in 2,269 white women, aged 40 to 69 years, who had been followed up for an average of 5.6 years in the Lipid Research Clinics Program Follow-up Study. A total of 72 deaths occurred during this period. The relative risk of death in estrogen users compared with nonusers was 0.54 in gynecologically intact women, 0.34 in hysterectomized women, and 0.12 in bilaterally oophorectomized women. The risk of death in estrogen users, irrespective of hysterectomy status, was 0.37 times that in nonusers (3.4/1,000 v 9.3/1,000). The significant negative association of estrogen use with mortality persisted after multivariate adjustment for confounding factors. Hysterectomy status alone was not a significant predictor of death. Some, but not all, of the lower risk of mortality in estrogen users can be accounted for by increased levels of high-density lipoprotein cholesterol. (<i>JAMA</i>1983;249:903-906)
Clinical features and natural history of 1154 Alagille syndrome patients: results from the international multicenter GALA study group
Authors: Shannon M. Vandriel, Li Liting, Huiyu She, Jian-She Wang, Piotr Czubkowski, Irena Jankowska, Dorota Gliwicz, David A. Piccoli, Kathleen Loomes, Nancy Spinner, Etienne Sokal, Tanguy Demaret, Lorenzo D’Antiga, Emanuele Nicastro, Rima Fawaz, Silvia Nastasio, Susan Siew, Michael Stormon, Henrik Arnell, Björn Fischler, Kyungmo Kim, Woo Yim Baek, Saul Karpen, Rene Romero, Winita Hardikar, Sahana Shankar, Amin J Roberts, Helen Evans, Maria Camila Sanchez, Maria Lorena Cavalieri, Palaniswamy Karthikeyan, Suzanne Davison, M.K. Jensen, Marianne Kavan, Henkjan Verkade, Way Seah Lee, James E. Squires, Chatmanee Lertudomphonwanit, Ryan Fischer, Henry Lin, Wikrom Karnsakul, Deirdre Kelly, Ruben E. Quiros-Tejeira, Cristina Targa, Elisa Carvalho, Seema Alam, Jesus M. Banales, Giuseppe Indolfi, Catherine Larson-Nath, Pinar Bulut, Pier Luigi Calvo, Pamela Valentino, Cigdem Arıkan, Kathleen Schwarz, Ino Kanavaki, Antal Dezsőfi, Raquel Borges-Pinto, Sabina Wiecek, Quais Mujawar, Jernej Brecelj, Nanda Kerkar, Ermelinda Santos-Silva, Carolina Jimenez-Rivera, Orith Waisbourd-Zinman, Gabriella Nebbia, Emmanuel Gonzales, Richard Thompson, Bettina Hansen, Binita M. Kamath
Journal: Journal of Hepatology (2020)
Elektrotherapie: Ein Lehrbuch.
Journal: JAMA (1929)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Exfoliated cytopathology of Acanthamoeba keratitis
Authors: C. E. Margo
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 4421: SY-5609, an orally available selective CDK7 inhibitor demonstrates broad anti-tumor activity <i>in vivo</i>
Authors: Shanhu Hu, Jason Marineau, Kristin Hamman, Michael Bradley, Anneli Savinainen, Sydney Alnemy, Nisha Rajagopal, David Orlando, Claudio Chuaqui, Eric Olson
Journal: Cancer Research (2019)

Abstract Previously, we reported on a series of highly potent, selective, and non-covalent CDK7 inhibitors that demonstrated antiproliferative activity against triple-negative breast cancer (TNBC) and ovarian cancer (OVA) cell lines and tumor growth inhibition in cell line-derived (CDX) and patient-derived (PDX) mouse xenograft models. Here, we report on the in vitro and in vivo profile of our development candidate, SY-5609. Methods: Kinase inhibition assays at both Km and 2 mM [ATP] were used to assess inhibition of CDK2, CDK7, CDK9, and CDK12. SPR was used to determine the Kd, kon, and koff binding characteristics of SY-5609 to immobilized CDK7/Cyclin H dimer. CDK7 compound occupancy was determined using a biotinylated small molecule probe to pull down free CDK7 following incubating of HL60 cells with SY-5609. Inhibition of tumor cell line growth was assessed following 72 hrs of incubation with SY-5609. Flow cytometry was used to assess apoptosis and cell cycle modulation after 48 hrs of treatment. Effects on DNA damage and repair were assessed by immunofluorescence staining for γH2AX and RAD51 proteins. To assess in vivo effects, mice were implanted subcutaneously and randomized for treatment when tumors reached 150-200 mm3 and dosed orally for 3 weeks by both QD and BID dosing regimens. Collected tumor tissue samples were analyzed for protein levels of MCL1, pCDK2, MYC, and RNA Pol II CTD pSer5 by western blot. Results: SY-5609 bound CDK7/Cyclin H with a Kd of 0.059 nM and occupied CDK7 in HL60 cells with an EC50 of 33 nM. Cell growth inhibition EC50 values were 6-17 nM in a panel of solid tumor cell lines. Selectivity of SY-5609 over CDK12, CDK9, and CDK2 was 2492-, 2508-, and 8068-fold, respectively. SY-5609 led to induction of apoptosis, cell cycle arrest, and inhibition of DNA damage repair in tumor cell lines. Dose-dependent tumor growth inhibition was observed in a panel of CDX and PDX solid tumor models with both QD and BID dosing of SY-5609 with resulting decreases in direct (pCDK2, RNA Pol II CTD pSer5) and indirect (MCL1, MYC) protein biomarkers. In summary, we describe SY-5609, an orally available, potent, and selective CDK7 inhibitor that drives strong responses in CDX and PDX tumor models. These data support the rationale for advancing SY-5609 into IND-enabling studies. Citation Format: Shanhu Hu, Jason Marineau, Kristin Hamman, Michael Bradley, Anneli Savinainen, Sydney Alnemy, Nisha Rajagopal, David Orlando, Claudio Chuaqui, Eric Olson. SY-5609, an orally available selective CDK7 inhibitor demonstrates broad anti-tumor activity in vivo [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4421.
Alcohol Advertising During Televised Sports and Alcohol Consumption by Adolescents—Reply
Authors: Matthew Nicholson
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Anesthetics and Their Administration.
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal