tbuckley/cabot-search huggingface dataset:
Trade-offs associated with axillary lymph node dissection: Implications of the eligibility versus enrollment in ACOSOG Z0011.
Authors: Monica Shalini Krishnan, Abram Recht, Jennifer Ruth Bellon, Rinaa Sujata Punglia
Journal: Journal of Clinical Oncology (2012)

151 Background: Results from ACOSOG Z0011 suggest that axillary lymph node dissection (ALND) may not be necessary for patients following positive sentinel lymph node biopsy (SLNB). Concerns have been raised regarding the generalizability of this trial, given the low-risk patient population. It is uncertain whether a subgroup who would have been eligible for ACOSOG Z0011 but were not adequately represented in the study may still benefit from ALND. Methods: We constructed a decision analysis using a Monte Carlo model to simulate axillary recurrence (ALR) risk, lymphedema, and quality of life of women age 45, 55, and 75 y/o with stage II cancers following breast conserving surgery (BCS) with positive SLNB who were then treated with either ALND and whole-breast radiation (BRT) or BRT alone. Women were divided into two risk groups: those with a risk of residual nodal involvement of 30-60% (high risk); and those with a risk less than 30% (low risk, similar to the Z0011 patients). Probabilities and utilities for health states were derived from previous studies. Results: BRT alone resulted in improved quality-adjusted life expectancy (QALE) in the low-risk group, while ALND with BRT resulted in improved QALE in the high-risk group. Overall survival (OS) was similar at 5 years with both treatment strategies in both groups but was superior with ALND at 20 years in the high risk group (Table). Differences in outcomes decreased with increasing age. In the low-risk group, sensitivity analysis showed BRT alone is preferred unless the ALR risk with BRT is greater than 1.6% or the lymphedema risk with ALND is less than 10%. In the high-risk group, ALND with BRT is the preferred strategy unless the ALR risk with BRT is less than 2.3%. Conclusions: Patients who would have been eligible for ACOSOG Z0011 but are at higher risk of having residual nodal disease following BCS and positive SLNB may benefit from ALND plus BRT rather than BRT alone. [Table: see text]
Post-Transplant Lymphoproliferative Disorder after Heart Transplant in the Pediatric Population: A Systematic Review
Authors: Mobeen Zaka Haider, Muhammad Taqi, Hasan Mahmood Mirza, Zarlakhta Zamani, Hafsa Shahid, Syed Maaz Abdullah, Khadija Noor Sami, Aneeza Irfan, Deepak Kumar, Saad Javed, Fnu Kiran, Faiz Anwer
Journal: Blood (2020)
Deaths
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Opium the Demon Flower.
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction: Error in Medicine
Journal: Annals of Internal Medicine (2001)

Corrections20 February 2001Correction: Error in MedicineFREESearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-134-4-200102200-00032 SectionsAboutVisual AbstractPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The article on error in medicine (1) contained two errors. First, Bogner's book, Human Error in Medicine, is actually in print (publisher, Lawrence Erlbaum). Second, the Massachusetts error reporting and feedback system is sponsored and run by the Massachusetts Board of Registration in Medicine, not by the Massachusetts Medical Society.Reference1. Bates DW, Gawande AA. Error in medicine: what have we learned? Ann Intern Med. 2000;132:763-7. [PMID: 0010787381] LinkGoogle Scholar Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoError in Medicine: What Have We Learned? David W. Bates and Atul A. Gawande Metrics 20 February 2001Volume 134, Issue 4Page: 347 ePublished: 20 February 2001 Issue Published: 20 February 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Chronic hypnotic-drug use. Ineffectiveness, drug-withdrawal insomnia, and dependence
Authors: A. Kales
Journal: JAMA (1974)

Ten patients, each of whom had been using hypnotic drugs for periods ranging from months to years, were monitored in the sleep laboratory while continuing to receive medication. Comparison with insomniac controls who were not receiving medication demonstrated a significant decrease of rapid eye movement (REM) sleep in the chronic drug users. A striking finding was the fact that all of these patients had as great or greater difficulty in falling asleep or staying asleep, or both, than the insomniac controls who were not using medication. Abrupt withdrawal of ineffective drugs is not recommended due to psychological and physiological changes that contribute to drug-withdrawal insomnia and hypnotic-drug dependence. The ineffectiveness of hypnotic drugs demonstrated in this study and in our earlier sleep laboratory drug evaluation studies indicates the need for changes in the guidelines used for evaluating and advertising hypnotic drugs.
Fake
Authors: Jordan D. Grumet
Journal: Annals of Internal Medicine (2002)

Ad Libitum2 July 2002FakeJordan D. Grumet, MDJordan D. Grumet, MDWashington University School of Medicine; St. Louis, MO 63108Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-137-1-200207020-00013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail With all the smugness of a physicianHe stares at meThis fakeWith glasses and clean-shaven faceLong white coatExpensive tiePressed pantsStethoscope wrapped around neckAnd large name tag with small name next to big M and DHe searches meWith great confidenceFor signs ofWeakness and frailtyAnxiety and insecurityDisease and infirmityBut I see right through this fakeHis quivering voice while answering superiorsHis insecurity in the face of peersHis questioning of decisions about patients' well-beingAnd only IWatch him belittle himselfEvery morningIn front of my mirrorBefore building enough courageTo leave his bedroomAnd go to work Author, Article, and Disclosure InformationAffiliations: Washington University School of Medicine; St. Louis, MO 63108Corresponding Author: Jordan D. Grumet, MD, 2321 Bryant Avenue, Evanston, IL 60201. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 2 July 2002Volume 137, Issue 1Page: 51KeywordsAnxietyFrailtyInterleukinsPatient advocacy ePublished: 2 July 2002 Issue Published: 2 July 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Distribution of total serum IgE and specific IgE to common aeroallergens by sex and age, and their relationship to each other in a random sample of the Dutch general population aged 20–70 years
Authors: M. Kerkhof, J. H. J. Droste, J. G. R. Monchy, J. P. Schouten, B. Rijcken
Journal: Allergy (1996)
Protease Inhibitors Interfere with the Necessary Factors of Carcinogenesis
Authors: Walter Troll
Journal: Environmental Health Perspectives (1989)

Many tumor promoters are inflammatory agents that stimulate the formation of oxygen radicals (.O2-) and hydrogen peroxide (H2O2) in phagocytic neutrophils. The neutrophils use the oxygen radicals to kill bacteria, which are recognized by the cell membrane of phagocytic cells causing a signal to mount the oxygen response. The tumor promoter isolated from croton oil, 12-O-tetradecanoylphorbol-13-acetate (TPA), mimics the signal, causing an oxygen radical release that is intended to kill bacteria; instead, it injures cells in the host. Oxygen radicals cause single strand breaks in DNA and modify DNA bases. These damaging reactions appear to be related to tumor promotion, as three types of chemopreventive agents, retinoids, onion oil, and protease inhibitors, suppress the induction of oxygen radicals in phagocytic neutrophils and suppress tumor promotion in skin cancer in mice. Protease inhibitors also suppress breast and colon cancers in mice. Protease inhibitors capable of inhibiting chymotrypsin show a greater suppression of the oxygen effect and are better suppressors of tumor promotion. In addition, oxygen radicals may be one of the many agents that cause activation of oncogenes. Since retinoids and protease inhibitors suppress the expression of the ras oncogene in NIH 3T3 cells, NIH 3T3 cells may serve as a relatively facile model for finding and measuring chemopreventive agents that interfere with the carcinogenic process.
Insulin Resistance and Non—insulin-dependent Diabetes
Authors: J. Nico D. de Neeling
Journal: JAMA (1995)

<h3>To the Editor.</h3> —Dr Pimenta and colleagues<sup>1</sup>state that they tested the hypothesis that insulin resistance precedes impaired beta-cell function in people genetically predisposed to develop non—insulin-dependent diabetes mellitus (NIDDM), but their study could not address their primary hypothesis. First, Pimenta et al took care to match the control subjects to the subjects with a first-degree NIDDM relative for body mass index. But rather than body mass index simply being the "environmental factor,"1 it seems plausible that there is some genetic constitution that, in the presence of excess energy intake or diminished physical activity, manifests itself phenotypically as hyperinsulinemia and obesity.<sup>2,3</sup>Thus, matching for obesity implies also matching, at least partially, for the insulin-resistant genotype, which clearly undermines the validity of the comparison between index and control groups with respect to the degree of genetically determined insulin sensitivity. Second, from the data on the age of the study
Lymphocytopenogenic Lymphocytotoxins
Authors: Robert S. Schwartz
Journal: New England Journal of Medicine (1969)

Antilymphocyte antibodies are usually thought of as the active ingredients of heterologous serums used for immunosuppression (horse anti-human lymphocyte serum, for example), but antibodies against lymphocytes occur in other contexts. The most familiar of these is that of isoimmunization brought about by either transfusions or pregnancy. Antilymphocyte isoantibodies, which fail to react with the patient's own lymphocytes, are of clinical importance as causes of transfusion reactions; their value as reagents for tissue typing is inestimable. Less well appreciated is the presence in normal human serum of at least two kinds of cytotoxic antilymphocyte antibodies. The first of these kills sheep . . .
Management of urinary incontinence and retention in the patient with advanced cancer
Authors: K. R. Herwig
Journal: JAMA (1980)

URINARY incontinence or retention occurring in the patient with advanced cancer is often devastating, adding further frustration to his illness and well-being. It also angers and frustrates the nursing staff, who demand that something be done, and presents a treatment challenge to the physician. The physician's response may pacify the nursing staff, but further aggrieve the patient, or satisfy the patient, but upset the nursing staff. A better response can be made when based on understanding the causes of the incontinence or retention that usually results in patient and nursing satisfaction. Before resorting to using an indwelling catheter, the physician should ask himself: Is there an effective alternative to the catheter? Will the treatment return the patient to a better level of functioning? If the physician were the patient, what would he want done? Answering these questions often results in alternative forms of therapy that offer more ideal solutions for
SportsMedUpdate
Authors: Martin P Schwellnus
Journal: British Journal of Sports Medicine (2010)

1. Strauss E, 2. Schachter A, 3. Frenkel S, 4. Rosen J . The efficacy of intra-articular hyaluronan injection after the microfracture technique for the treatment of articular cartilage lesions. Am J Sports Med 2009;37:120–6. [OpenUrl][1][Abstract/FREE Full Text][2] ### Background Intra-articular hyaluronic acid viscosupplementation has been used in the treatment of cartilage injury possibly because of its chondroprotective and anti-inflammatory properties. ### Research question/s In an animal model of cartilage injury, does intra-articular hyaluronic acid administration following microfracture improve the quality of the repair? ### Methodology Animal material Thirty-six female New Zealand White rabbits. Experimental procedure In all the animals, full-thickness cartilage defects were created in the weight-bearing area of the medial femoral condyle and then treated with surgical microfracture. Two groups of rabbits were then studied (a 3-month and 6-month group) and then killed for analysis of the knee tissue. In each group, rabbits were randomly assigned to three subgroups: three weekly injections (Hyal3=6), five weekly injections (Hyal5=6) of hyaluronic acid or saline injections (Con=6). Repair tissue was assessed (1) grossly (using a modified component of the International Cartilage Repair Society (ICRS) Cartilage Repair Assessment scoring scale) and (2) histologically (using the modified O'Driscoll histological cartilage scoring system). Measures of outcome Gross (ICRS scores) and histological score between groups and time (3 and 6 months). © 2008 MPAH Medical cc. All rights reserved. www.sportsmedupdate.info ### Main finding/s There was a significantly greater degree of synovial inflammation and osteophyte formation in the Con group compared with the Hyal3 and Hyal5 groups (p<0.05) on examination of the entire operative knee. ### Conclusion/s In an animal model of an induced knee cartilage injury that is treated with … [1]: {openurl}?query=rft.jtitle%253DAm%2BJ%2BSports%2BMed%26rft_id%253Dinfo%253Adoi%252F10.1177%252F0363546508324694%26rft_id%253Dinfo%253Apmid%252F19029314%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/ijlink?linkType=ABST&journalCode=amjsports&resid=37/1/120&atom=%2Fbjsports%2F44%2F5%2F392.atom
The public's view of the future of health care
Authors: R. J. Blendon
Journal: JAMA (1988)

An analysis of more than two decades of poll results has identified six major trends in public opinion likely to affect the health care system of the 1990s. Americans favor more rather than less health spending, at least as long as the economy remains strong, and they do not think the deficit problem requires cuts in medical care outlays. Should there be a serious economic downturn, however, the public would reverse itself and would favor reduced spending that relies on a different set of strategies than those favored by most health policy experts, particularly in regard to spending for care for the elderly. In either case, the poll results suggest that Americans may be less inclined to participate in newer forms of medical practice, such as health maintenance organizations or preferred provider organizations, than anticipated, and that the commercialization of health care is leading to a decline in public confidence in the leaders of medicine. This latter trend may result in a lack of trust in professionals' views concerning the quality of care and may presage more stringent government involvement in and regulation of health services. (<i>JAMA</i>1988;259:3587-3593)
Late-Onset Type of Skeletal Muscle Phosphorylase Deficiency: New Familial Variety with Completely and Partially Affected Individuals
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THERAPEUTIC TENDENCIES
Authors: C. Whitby
Journal: BMJ (1921)

tlle role of the yeast plant in fermentation, and Davaine's identification of the antlirai bacillus.Like all great discoveries, this *was but tlhe bringing into -clear lighIt of a principle already adunibrated in the consciousness of man- kind.The practice of inoculation for small-pox was begun in tlle early part of the eighteenth century, the famous
Abstract 21189: High Diastolic Blood Pressure (DBP) and Outcomes in Patients With Heart Failure and Preserved Ejection Fraction (HFpEF) and Hypertension (HTN): Findings From Medicare-Linked OPTIMIZE-HF Registry
Authors: Daniel J Dooley, Phillip H Lam, Gregg C Fonarow, Ali Ahmed
Journal: Circulation (2017)

Background: According to 2017 update of 2013 ACCF/AHA HF guideline, systolic BP (SBP) should be lowered to &lt;130 mmHg in euvolemic patients (pts) with HFpEF and persistent HTN. However, little is known about the role of high diastolic BP (DBP) on outcomes in these patients. Methods: Of the 10482 hospitalized pts with decompensated HFpEF (EF &gt;40%) discharged alive, 2652 had HTN, defined as SBP ≥140 or DBP ≥90 mmHg at both admission and discharge. Of these, 289 had a discharge DBP ≥90 mmHg. Propensity scores for DBP ≥90 mmHg, estimated for each of the 2652 pts, were used to assemble a cohort of 263 pairs of pts, with a discharge DBP ≥90 and &lt;90 mmHg, balanced on 40 baseline characteristics including discharge SBP. The 526 matched pts (52% women, 24% African American) had mean (±SD) age of 74 (±13) years, EF of 56 (±8) %, and discharge DBP of 84 (±13) mmHg. Results: During 6 (median, 3) years of follow-up, all-cause mortality occurred in 73% and 61% of matched pts with a discharge DBP ≥90 vs &lt;90 mmHg, respectively (HR, 1.36; 95% CI, 1.10-1.67; p=0.004; Figure ). HF readmission occurred in 54% and 43% of matched pts with DBP ≥90 vs &lt;90 mmHg, respectively (HR, 1.37; 95% CI, 1.06-1.75; p=0.015). There was no association with all-cause readmission (HR, 1.05; 95% CI, 0.86-1.26). Conclusion: About 1 in 10 hospitalized patients with HFpEF and HTN had a discharge DBP ≥90 mmHg, which was associated with a higher risk of mortality or morbidity.
In This Issue of JAMA Pediatrics
Journal: JAMA Pediatrics (2013)

Suctioning and Length of Stay in InfantsHospitalized With Bronchiolitis M ussman et al (page 414) studied suctioning in infants hospitalized with bronchiolitis and found that the use of deep suctioning in the first 24 hours after admission and lapses greater than 4 hours between suctioning events were associated with longer length of stay. Decreasing Hospital Length of Stay for Bronchiolitis by Using an Observation Unit and Home Oxygen Therapy
Inhibition of hepatocellular carcinoma development in hepatitis B virus transfected mice by low dietary casein.
Authors: Z Cheng
Journal: Hepatology (1997)

In a comprehensive human ecological study, primary liver cancer has been shown to be highly significantly associated with 1) the prevalence of persistent infection with hepatitis B virus (HBV) and 2) plasma cholesterol concentrations that are, in turn, associated with the consumption of animal based foods. In rat studies, aflatoxin-induced hepatocellular carcinoma is substantially prevented by decreasing the intake of animal based protein (casein), a hypercholesterolemic nutrient. Thus the development of primary liver cancer associated with persistent HBV infection or with aflatoxin exposure may be controlled by reduced intake of animal-based proteins. Transgenic mice transfected with an HBV gene fragment containing the viral transactivator of hepatis B virus, HBx, which induces the formation of hepatocellular carcinoma, were used to examine the ability of dietary casein to modify tumor formation. Reducing the concentration of dietary casein to 6% from the traditional level of 22% markedly inhibited (by 75%) hepatic tumor formation in these transgenic mice. Tumor development also was substantially altered by interchanging dietary casein concentration well after tumor development had begun (at 8 months), increasing by 173% from the expected yield when casein intake was increased and decreasing by 99% when casein was reduced. These findings suggest that the development of liver tumor formation among individuals persistently infected with HBV may be controlled by minimizing or eliminating the intake of animal protein-based foods. (Hepatology 1997 Nov;26(5):1351-4)