tbuckley/cabot-search huggingface dataset:
Improved endoscopic diagnosis of gastroesophageal malignancy. Combined use of direct vision brushing cytology and biopsy
Authors: S. Kobayashi
Journal: JAMA (1970)

Modern endoscopic instruments for examination of the esophagus and stomach are constructed to allow diagnostic cytology by brushing and biopsy of lesions under direct vision. The conditions of all 26 patients with cancer of the upper gastrointestinal tract were correctly diagnosed by the combination of direct-vision brushing cytology and biopsy, while roentgenographic and endoscopic examination alone were successful in only 73.3% and 83.3% of the cases, respectively. Such instruments, therefore, provide a safe, convenient, and accurate method for the definitive, microscopical diagnosis of gastroesophageal malignancy. They are of special value in the correct identification of malignant gastric ulcers of benign gross appearance.
Subject Index
Authors: Giovanni A. Fava, Barrie R. Cassileth, Douglas A. Drossman, Howard Berenbaum, E.H. Friedman, Paul M.G. Emmelkamp, Patricia van Oppen, Bernhard Strauss, Manuela Burgmeier-Lohse, Gereon Heuft, Wolfgang Senf, T. Platz, B. Junkert, W. Tress, H. Schepank, F. Anagnostopoulos, Gr. Vaslamatzis, M. Markidis, Kl. Katsouyanni, St. Vassilaros, C. Stefanis, Wolfgang Wöller, Johannes Kruse, Petra Winter, Elmar J. Mans, Luciano Alberti, James D.A. Parker, Graeme J. Taylor, Michael Bagby, Douglas E. Webb, Jr., Joen Fagan, George M. Simpson
Journal: Psychotherapy and Psychosomatics (1993)
Systemic Reaction to Bromsulphthalein
Authors: T. W. Astin
Journal: BMJ (1965)

MEDIBAHJONALThe plastic loop was cut on the right side (Fig. 3), the gangrenous gut resected, and an end-to-end anastomosis performed.A half- inch (12.7 mm.) incision was made at the site of rupture, the intra- uterine device dislodged, and the incision and tear repaired.Bilateral tubal ligation was done.Apart from a post-operative pyrexia which subsided on the eighth day after the operation, the patient's recovery was uneventful.
Internal Medicine
Authors: Alfred Soffer
Journal: JAMA (1979)

<i>How many internists are necessary for optimal health care in the United States, and how do these needs relate to the total medical manpower issues confronting the nation? What are the factors responsible for the current interest in general internal medicine in academic centers and in internal medicine societies? A perceptive analysis of recent developments and future trends is presented by Mark Siegler, MD, and Alvin Tarlov, MD. These coauthors are uniquely qualified to present an authoritative update on internal medicine today. Siegler, a member of the faculty of the University of Chicago Department of Medicine, was coeditor of a special issue of the</i>Archives of Internal Medicine<i>devoted to the subject of "The Role, Training and Responsibilities of the General Internist" (</i>Arch Intern Med<i>137:1271-1334, 1977). He and his colleagues have</i>published many reports in recent years on such subjects as "Development of an Academic Section of General Internal Medicine, " "The University Medical School Reaching to the Community Physician," and "A Right to Health Care: Ambiguity, Professional Responsibility and Patient Liberty." His interests in clinical ethics and in medical education have resulted in the formulation of creative approaches to the physician-patient relationship. Siegler contends that the patient should have a primary principal physician. This clinician should assume ultimate responsibility for the complex system of health care involved in diagnosis and therapy. In a sense this physician is an advocate of the patient in dealing with the hospital, the consultants, and the clinical laboratory. Tarlov is chairman of the Department of Medicine of the University of Chicago. He is chairman of the Federated Council for Internal Medicine and president-elect of the Association of Professors of Medicine. His skills and authority in the realm of manpower needs in internal medicine are widely respected. These interests encompass health manpower planning for all disciplines in medicine, and this leadership role has recently been recognized by the secretary of Health, Education, and Welfare (DHEW). Secretary Califano named Tarlov as chairman of the Graduate Medical Education National Advisory Committee of DHEW. Responsibilities of this committee are to assess the number of physicians needed in the United States and to make recommendations on the distribution of professionals among the various medical specialties, how they should be deployed geographically, how graduate medical education should be financed, and what the role of the federal government should be in influencing all of these factors. Tarlov heads another national project to evaluate aspects of this problem; he is the chairman of the Association of Professors of Medicine Task Force on Manpower Needs in Internal Medicine.—A.S.
Autologous Transfusion
Authors: Bak M. Lee
Journal: JAMA (1976)

<h3>To the Editor.—</h3> The article by Herbert Silver, MD (235:1611, 1976) emphasized the usefulness of "new autologous-blood techniques," ie, a recycling of the blood that has been lost into a closed cavity. This technique is described as "Intraoperative Salvage Autologous Transfusion" in<i>Technical Method and Procedures of the American Association of Blood Banks</i>and in "Retransfusion of Blood Obtained From the Peritoneal Cavity" in<i>Blood Transfusion in Clinical Medicine</i>by P. L. Mollison, MD, FRCP. This technique is said to have been used before the development of transfusion service—as early as 1818. Despite the advantages indicated by Dr Silver, there are complications, such as, hemolysis, microemboli, and consumptive coagulopathy. Also, it was found that the blood collected in the peritoneal cavity was unsuitable for transfusion in many incidents. Because of a possibility of higher incidence of the dangerous transfusion reaction in this technique, unless the additional clinical study shows the
Medical Education, Registration and Hospital Service
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An Arteriosclerotic Chiasmal Syndrome
Authors: George F. Hilton
Journal: JAMA (1966)

IN A REVIEW of the blood supply to the optic chiasm published in 1958, Hughes implied that arteriosclerosis in the elderly patient can, on rare occasions, cause a classical chiasmal syndrome (optic atrophy, bitemporal field -defects, and a normal sella turcica).<sup>1</sup>He referred specifically to the case of a 74-year-old man with generalized arteriosclerosis who suffered the abrupt onset of uppertemporal-field defects, and he deduced from findings in this case and from findings in "a few related cases" that the responsible occlusive vascular changes had occurred in small prechiasmal vessels derived from the anterior cerebral arteries. In 1960, Walsh and Gass called attention to a direct effect of sclerotic anterior cerebral arteries on the chiasm.<sup>2</sup>They showed a necropsy specimen (Fig 1) in which they found compression and distortion of the chiasm and optic nerves by sclerotic, elongated, and prolapsed anterior cerebral arteries. They had no information regarding
The Pathology of Influenza Virus Infections
Authors: Jeffrey K. Taubenberger, David M. Morens
Journal: Annual Review of Pathology Mechanisms of Disease (2007)

Influenza viruses are significant human respiratory pathogens that cause both seasonal, endemic infections and periodic, unpredictable pandemics. The worst pandemic on record, in 1918, killed approximately 50 million people worldwide. Human infections caused by H5N1 highly pathogenic avian influenza viruses have raised concern about the emergence of another pandemic. The histopathology of fatal influenza virus pneumonias as documented over the past 120 years is reviewed here. Strikingly, the spectrum of pathologic changes described in the 1918 influenza pandemic is not significantly different from the histopathology observed in other less lethal pandemics or even in deaths occurring during seasonal influenza outbreaks.
Antimicrobial Chemotherapeutic Agents: The Nature of Their Action and Selective Toxicity
Authors: David S. Feingold
Journal: New England Journal of Medicine (1963)

Agents Affecting Protein SynthesisGeneral CommentsIn bacteria ribosomes are the sites of protein synthesis. These subcellular organelles constitute the workbenches on which amino acids are ordered into the polypeptide chain of the protein. Current theory holds that the amino acid sequence of the polypeptide chain is dictated by a labile RNA moiety called messenger or template RNA (m-RNA). The m-RNA synthesis is, in turn, directed by DNA and reflects in its ribonucleotide chain the deoxyribonucleotide sequence or coding sequence of the hereditary material. Amino acids are activated by specific activating enzymes and transferred to specific soluble RNA (s-RNA, also . . .
The Nervous Patient: A Frontier of Internal Medicine
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Vision-Related Problems May Offer Clues for Earlier Diagnosis of Alzheimer's Disease
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Inhibition of HBV replication by siRNA in a stable HBV-producing cell line
Authors: Masayoshi Konishi, Catherine H. Wu, George Y. Wu
Journal: Hepatology (2003)

Potent inhibition of endogenous gene expression by RNA interference has been achieved by using sequence–specific posttranscriptional gene silencing through the action of small interfering RNA molecules (siRNA). In these reports, the natural function of genes could be deduced through the ensuing loss of function. Based on the extraordinary effectiveness in silencing endogenous genes, we wondered whether siRNA could be applied against viral replication in a hepatitis B virus (HBV) model using HBV–specific siRNA. To test this idea, HepG2 2.2.15, a human hepatoblastoma cell line that constitutively produces infectious HBV particles, was transfected with HBV–specific siRNAs and controls. HBV surface antigen (HBsAg) secretion into culture media was inhibited by 78%, 67%, and 42% with siRNA against the polyadenylation (PA), precore (PreC), and surface (S) regions, respectively, compared with controls as detected by enzyme–linked immunosorbent assay. After exposure to HBVPA siRNA, Northern blot analysis showed that HBV pregenomic RNA levels were decreased by 72%, and levels of HBV RNA containing the polyadenylation signal sequence were suppressed by 86%, as detected by RNase protection assay. Levels of HBV coreassociated DNA, a replication intermediate, also decreased by 71%. Immunocytochemistry revealed that 30% to 40% of the cells transfected with HBVPA siRNA were completely negative for detectable HBsAg levels. Controls consisting of treatment with HBV–specific siRNA alone, lipofection reagent alone, or random double–stranded RNA (dsRNA) lipofection complex failed to decrease HBV surface antigen, HBV messenger RNA (mRNA), or core–associated HBV–DNA levels. In conclusion, siRNA inhibits hepatitis B viral replication in a cell culture system. Future studies are needed to explore the specific delivery of siRNA to liver cells in vivo and the applicability of this approach. (Hepatology 2003;38:842-850).
Support Loan Deferment
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE FACTOR OF INTESTINAL ABSORPTION IN RICKETS
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Toward a National Child Health Policy
Authors: Birt Harvey
Journal: JAMA (1990)

<i>A 2-year-old has otitis media. She is the only child of parents whose combined monthly income is $800</i>. In Alaska this child would be eligible for care under the state Medicaid program. In Alabama she would not be eligible because her parents earn more than $120 per month.<sup>1</sup> <i>A 3-year-old and a 5-year-old both have pneumonia. They live with their mother, who earns $5000 per year working part time</i>. In New Jersey, care for the 3-year-old is available through Medicaid. This is not true of the 5-year-old sibling.<sup>1</sup> <i>An infant develops acute leukemia. His family has insufficient insurance or other financial sources to pay for his care</i>. In Arkansas this child would receive care through Children's Special Care Services, the state's crippled children's program. In Colorado no state-supported medical care would be available (S. Kessel, MD, MPH, oral communication, Feb 10, 1990). Three 4-year-olds who live in equal
BRAF/MEK Combo Approved for Melanoma
Journal: Cancer Discovery (2018)

The FDA approved the BRAF/MEK inhibitor combination encorafenib/binimetinib for patients with metastatic or inoperable melanoma with a BRAF V600E or V600K mutation. The approval was based on results of a phase III trial in which patients treated with the combination had a median progression-free survival of 14.9 months, compared with 7.3 months in a control group that received vemurafenib alone.
An Unusual “Side Effect” of an Acne Drug
Journal: Annals of Internal Medicine (2002)

Summaries for Patients16 April 2002An Unusual “Side Effect” of an Acne DrugSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-136-8-200204160-00003 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Isotretinoin (Accutane) is a vitamin A–like drug used to treat severe acne. It is a pill that is taken by mouth and is usually given to people who do not respond to treatment applied directly to the skin (topical). Isotretinoin may cause side effects, including birth defects, liver problems, hair loss, and increases in fatty substances in the blood (triglycerides). Researchers do not know why or how isotretinoin increases triglyceride levels. They think that persons who have a family or genetic tendency to develop very high levels of ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “High Risk for Hyperlipidemia and the Metabolic Syndrome after an Episode of Hypertriglyceridemia during 13-cis Retinoic Acid Therapy for Acne: A Pharmacogenetic Study.” It is in the 16 April 2002 issue of Annals of Internal Medicine (volume 136, pages 582-589). The authors are N Rodondi, R Darioli, A-A Ramelet, D Hohl, V Lenain, J Perdrix, V Wietlisbach, WF Riesen, T Walther, L Medinger, P Nicod, B Desvergne, and V Mooser.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoHigh Risk for Hyperlipidemia and the Metabolic Syndrome after an Episode of Hypertriglyceridemia during 13-cis Retinoic Acid Therapy for Acne: A Pharmacogenetic Study Nicolas Rodondi , Roger Darioli , Albert-Adrien Ramelet , Daniel Hohl , Vincent Lenain , Jean Perdrix , Vincent Wietlisbach , Walter F. Riesen , Thomas Walther , Laurent Medinger , Pascal Nicod , Béatrice Desvergne , and Vincent Mooser Metrics 16 April 2002Volume 136, Issue 8Page: I-38KeywordsAcneBloodGeneticsHypercholesterolemiaHyperlipidemiaInsulinLipidsObesityRisk managementSevere blood loss ePublished: 16 April 2002 Issue Published: 16 April 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
MEDICAL EDUCATION FOR WOMEN.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal