tbuckley/cabot-search huggingface dataset:
Varicose Veins, Oral Contraceptives, and Thromboembolism
Authors: H. O. Jones, J. C. F. Townsend
Journal: BMJ (1967)

the villages there was no significant change in the incidence of scabies.About a year ago we stopped using benzyl benzoate and started using monosulfiram soap, advising the patients to allow the soap to dry on the skin.In this way an effective concentration of monosulfiram is built up on the skin and in the clothes and bedding.The results have been quite remarkable, and scabies has almost disappeared in some villages.The only obstacle to complete eradication seems to be the cost of the soap at 2s. each in a country where a manual worker earns only 6s. a day when he can find work.I was surprised to see no mention of mono- sulfiram in the copies of the B.M.7.which have reached me so far.-Iam, etc.,
FEASIBILITY AND EFFICACY OF A NOVEL NEEDLE IN ENDOSCOPIC ULTRASOUNDGUIDED TISSUE SAMPLING FOR PANCREATIC SOLID LESIONS: A PROSPECTIVE RANDOMIZED COMPARATIVE STUDY
Authors: EK Choi, CM Cho
Journal: Endoscopy (2020)

Aims Histologic confirmation is crucial in the evaluation of pancreatic solid lesions. Recently, variable needles with different shapes for endoscopic ultrasound guided tissue sampling (EUSTS) have been used, however, most needles are expensive. Therefore, new needle with novel technology and reasonable price is needed. We evaluated the feasibility and efficacy of a newly designed prototype needle for pancreatic solid lesions.
MILK FROM TUBERCULOUS COWS.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Contributions to a New Chapter in the Physiology and Pathology of the Nervous System
Authors: T. Laycock
Journal: BMJ (1868)

I ORIGINALLY intended that my promiscd clinical contributions to a new chapter in the physiology and pathology of the nervous system should be cases witlh comments, after the orthodox plan; but, on re- consideration, I find I cannot contribute satisfactorily or usefully with- out a preliminary exposition of certain principles.Every one becomes aware of the value of sound general principles in science, so soon as, after having passed through the inevitable ordeal of neglect, doubt, ridi.cule, and misapprehension which awaits all novel views, whether they be true or false, they have been successfully applied to practice.Previ.ously to this judgment in his favour, however, the expounder of novel.ties and heterodoxies has a thankless duty to perform, and is not only inevitably subject to loss of time and labour, but also of what is more tangibly valuable.It is an old, old story, although it is right to say, that of late years there is much more tolemtionwithin the medical.professionfor new views.Nevertheless, "the wisest, virtuousest, dis- creetest, best," are apt to resent the overthrow of time-honoured doc-
Massachusetts Medical Society
Authors: Robert W. Buck
Journal: New England Journal of Medicine (1957)

COMMITTEE ON MATERNAL WELFAREEclampsia Followed by Pulmonary EdemaAn eighteen-year-old gravida 1 died with pulmonary edema after having had at least twelve eclamptic convulsions.This patient applied for prenatal care in about the twenty-sixth week of pregnancy, when the blood pressure was recorded at 122 systolic, 78 diastolic, and the urine was normal. The weight was not recorded at this or subsequent visits, but a relative later remarked that the patient had gained 18.1 kg. (40 pounds). The only other blood pressure recorded before admission in the thirty-seventh week of pregnancy was 124 systolic, 80 diastolic, two weeks earlier. . . .
Growing world of gastrointestinal endoscopy
Authors: M. Reed
Journal: JAMA (1982)

In this age of computed tomographic scans, ultrasound, and nuclear magnetic resonance, medical technology grows more exciting, if more complex and expensive, each day. Thus it is easy to overlook the growing sophistication and importance of a less exotic instrument like the endoscope. At the recent Digestive Disease Week (DDW) meetings in Chicago, a large number of plenary- and poster-session presentations and commercial exhibits coalesced into a fascinating documentation of the current significance and promise of this device. In his 20 years as director of the program of gastroenterology at the University of Wisconsin Medical School, Madison, John F. Morrissey, MD, says he has observed endoscopy's growth from a struggling young technique practiced with comparatively primitive endoscopes to a precise and highly valued procedure based on technologically superb equipment. Today, endoscopes and endoscopists are in the midst of an extension from observation to manipulation and from diagnosis to therapy. In
Announcement of CDC Name Change
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Creativity requires nurture
Authors: C. Aring
Journal: JAMA (1977)

IT APPEARS likely that the times have a lot to do with fostering and promoting creativity or suppressing it. Alfred Kroeber<sup>1</sup>put forward evidence that people possessing higher civilization have produced cultural products only intermittently during relatively small fractions of their time span. He pointed to the lack of genius in England during the century between 1450 and 1550 and to a whole series of genius of all sorts between 1550 and 1650. The same holds true in innumerable other instances in history, for example, in the Germany of 1550 to 1650 and 1700 to 1800. It would seem to follow that some born with an endowment for creativity have been submerged by the times into which they were born. One period that stands out because of the genius that appeared then was 1809 and the years immediately following. Born in 1809 were Charles Darwin, Edward Fitzgerald, William Gladstone,
FUNCTION OF THE PERIOSTEUM IN BONE REPAIR
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PREVENTIVE INOCULATION.
Journal: JAMA (1889)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A horizon scan of global conservation issues for 2013
Authors: William J. Sutherland, Sarah Bardsley, Mick Clout, Michael H. Depledge, Lynn V. Dicks, Liz Fellman, Erica Fleishman, David W. Gibbons, Brandon Keim, Fiona Lickorish, Ceri Margerison, Kathryn A. Monk, Kenneth Norris, Lloyd S. Peck, Stephanie V. Prior, Jörn P.W. Scharlemann, Mark D. Spalding, Andrew R. Watkinson
Journal: Trends in Ecology & Evolution (2012)
Typographical Error in Results
Authors: Vilakshan Alambyan, Ciro Ramos-Estebanez
Journal: JAMA Neurology (2019)

Colin B. Josephson, MD, MSc, FRCPC; Jordan D. T. Engbers, PhD; Nathalie Jette, MD, MSc; Scott B. Patten, MD, PhD; Shaily Singh, MD, DM; Tolulope T. Sajobi, PhD; Deborah Marshall, PhD; Yahya Agha-Khani, MD; Paolo Federico, MD, PhD; Aaron Mackie, MD; Sophie Macrodimitris, PhD; Brienne McLane, MD; Neelan Pillay, MB ChB; Ruby Sharma, PhD; Samuel Wiebe, MD, MSc
Nivolumab safety profile in Asian and Western patients with chemotherapy-refractory (CTx-R) advanced gastric/gastroesophageal junction (adv G/GEJ) cancer from the ATTRACTION-2 and CheckMate-032 trials.
Authors: Ian Chau, Li-Tzong Chen, Yoon-Koo Kang, Taroh Satoh, Ken Kato, Hyun Cheol Chung, Won Ki Kang, Yee Chao, Jen-Shi Chen, Patrick Alexander Ott, Dung T. Le, Huanyu Zhao, Maria Jesus Jimenez-Exposito, Yelena Yuriy Janjigian, Narikazu Boku
Journal: Journal of Clinical Oncology (2018)

90 Background: Nivolumab (NIVO) monotherapy demonstrated a survival benefit and durable responses in pts with CTx-R adv G/GEJ cancer (Boku N et al ESMO 2017; Janjigian Y et al ASCO 2017). Here we describe the safety profile of NIVO in Asian (A) and Western (W) pts with CTx-R adv G/GEJ who had received ≥ 2 prior CTx in the ATTRACTION-2 and CheckMate-032 trials, respectively. Methods: The safety population included pts who received ≥ 1 dose of study drug at the data cutoff of August 2016 for ATTRACTION-2 and March 2016 for CheckMate-032. TRAEs, serious TRAEs, and select TRAEs (sTRAE; with a potential immune-related etiology) were assessed. sTRAEs were managed using protocol-specified algorithms, which included corticosteroids as immune-modulating treatment (tx). Time to onset and resolution of sTRAEs were also assessed. Results: Median duration of NIVO tx was 1.9 mo in A and 2.3 mo in W pts. TRAEs (any grade) were reported in 43% of A and 64% of W pts; grade 3–4 TRAEs (A pts:10%; W pts:14%), serious TRAEs (A pts:10%; W pts:7%) and TRAEs leading to discontinuation (≤ 3% of pts in both groups) were infrequent. Most sTRAEs were grade 1–2 (Table) and occurred within the first 3 mo of NIVO tx. In A and W pts, median time to resolution of sTRAEs ranged from 3–19 wk. For those sTRAEs that required tx with immune-modulating agents, the median time to resolution of most sTRAEs ranged from 3–35 wk. Conclusions: NIVO demonstrated an acceptable safety profile in both A and W pts with CTx-R adv G/GEJ cancers with no clinically meaningful racial differences. Most sTRAEs were grade 1–2 in both cohorts and manageable using the recommended tx algorithms. Clinical trial information: NCT02267343 ATTRACTION-2 and NCT01928394 CheckMate 032. [Table: see text]
Some Aspects of the Problem of Regulation of Food Intake and Obesity
Authors: Jean Mayer
Journal: New England Journal of Medicine (1966)

Glucostatic Mechanism Early work. My co-workers and I propounded the concept of the glucostatic mechanism of regulation of food intake in the early 1950's.1, 33 , 34 It was proposed that in the ventromedial (satiety) hypothalamic centers (and possibly in other central and peripheral areas) there are glucoreceptors sensitive to blood glucose in the measure that they utilize it. This concept was based on the facts that the central nervous system is dependent for its function on the availability of glucose, that carbohydrates are preferentially oxidized and are not stored in any appreciable amount, so that their depletion is rapid, and that . . .
Large F tus: a Correction
Authors: John Murrays, John Murray, J Althaus, : London, A Boycott, Mr Burton, Mr Beddard, F Blumer, Messrs Bur-, Mr Burroughs, J Bruce, London Bidwell, J Bird, Carlisle Mr, J Bush, E Baylor, Ash Bishop, Cargona Com- Pany, F Coutts, Dublin Carter, A Cooper, Staveley Court, G Crowe, Mr Danvers, W Drummond, E Diver, Enfield Company, W Mca, C Edmondson, ; Edgar, Messrs Fassett, London Fides, F Fair, A Frere, W Grant, Mr Gordon, Mrs Mcc, G Gilmer, Mr German, Liverpool Sir, J Grant, L Guthrie, T Griffith, W Hutton, Bir- Mingham Haslam, Mr Haydon, J Huber, Rev Horsley, J Henry, Mr Edinburgh, Mr Humphry, T Hyslop, Skipton-In- Craven Huthwaite, J Johnston, Northwich Joynson, T Kelynack, E Knowling, Burton-On-Trent Lilwall- Cormac, D Love, Cumbernauld Levillain, Liverpool Lowndes, Messrs Larcome, ; Veysey, Heywood Laird, W Milligan, Messrs Mayer, London Meltzer, Mr Marriott, W Mccardie, L Mcdowell, Hope Town, T Myles, Mr Mackinlay, Mr Montague, R Mills, W Cormac, A Martin, G Tmurray, Mr Morgan
Journal: BMJ (1898)

Inotice another attempt to denounce the use of the customar-y symbols in prescription-writing.The fact of a fatal misadventure lhaving recently occurred lhas apparently prolmipted the writer in this instance, and he thinks that "at this time of day we can afford to dispense witlh these symbols considering the danger to human life ......... Would "J.M.Y." not think it advisable to dispense witlh the " opiumll "also, for the very same reason "at this time of day"?The inishap referred to was caused simply by the fact that the prescription camne inito the lhands of a person for whom it was in no wise intended.and to whom it should naturally be quite unintelligible.Wlhat has a ' nurse" got to do witlh the reading of prescriptions ?They are ineant solely and exclusively for a qualified chemist, and if they are invariably transferred to his hands, all the directions necessary for nurse, etc., will appear in plain English on the label attached to the medicine, and mistakes cannot occur.I see no reason for the change suggested by "J.M.Y." (and by others who have already trotted out similar suggestions), and am of opinion that, should the change be adopted, it would lead to very muclh greater danger in the same direction.No; life is too short to enable the busy practitioner to write his prescriptions always in plain Englisl ,(which language is, I presume, implied by " tern4s understood by all ").Abbreviations would, of course, result, increasing very materially the probability of such mishaps.I tlink it more than probable that ,every medical man who is a master of the art of prescription writing (alas I a much-neglected itenm in professional education nowadays) wil I rigidly adhere to the symbols wlhich experience lhas proved to be exceedingly conveniient, thoroughly efficient, anid absolutely safe-if used only by thlose who know hiow-from ages past to "this timiie of 'day.
Radiofrequency Pacer May Greatly Reduce Reoperation Rate
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 5175: Expression profile and role of LOXL3 in astrocytomas
Authors: Talita de Souza Laurentinho, Roseli da Silva Soares, Suely Kazue Marie, Sueli Mieko Oba-Shinjo
Journal: Cancer Research (2019)

Abstract Astrocytomas are the most common primary central nervous system tumors in adults. The WHO classification based on histologial characteristics according consider four malignant grades, glioblastoma (GBM) being the most malignant (grade IV). Molecular classification of GBM is based on the integration of somatic mutations, DNA methylation and specific transcript/protein expression and consider four subtypes: proneural, classic, mesenchymal and neural. Lysyl oxidase family is composed of five members (LOX, LOXL1, LOXL2, LOXL3 and LOXL4) which are enzymes responsible for catalyzing lysine-derived cross-links of collagen and elastin. The aim of the present work was to analyze the gene expression of LOXL3 in astrocytomas of different grades and different GBM molecular subtypes, the impact of LOXL3 expression level on overall survival in GBM cases of our cohort. These data were also analyzed in the TCGA database to validate our findings. LOXL3expression increased with astrocytoma malignant grades, and proved to be a prognostic factor, as GBM patients with lower LOXL3 expression presented longer survival time than those with higher expression (p&amp;lt;0.041). Analogous data was obtained in the TCGA database, when considering temozolamide-treated GBM patients (p=0.049). Additionally, LOXL3 expression was higher in mesenchymal GBM subtype than in proneural and classic GBM subtypes in TCGA cohort (p&amp;lt;0.001). To further understand LOXL3 functional role in gliomagenesis, LOXL3 was silenced with two distinct siRNA sequences in U87MG, a mesenchymal subtype of GBM cell line. LOXL3 down regulation was confirmed at gene and protein expression levels. Functional assays with silenced LOXL3 demonstrated a decrease in the cell proliferation (p&amp;lt;0.05), and an increase in the apoptosis associated to temozolamide treatment (p&amp;lt;0.05). Immunofluorescence analysis in U87MG cells showed LOXL3 colocalized with mitochondria. Interestingly, such colocalization decreased when LOXL3 was downregulated, associated to a clear morphological alteration in mitochondria shape. A rough increase in mitochondria volume was observed, suggesting fused mitochondria. In addition, such condition was associated to a 23% decrease in mitochondrial DNA copy number. Altogether, our findings suggest that LOXL3 is upregulated in GBM, with impact in prognosis and might play a role in mitochondria dynamics and/or mitophagy, modulating apoptosis. Transcriptome analysis, currently in progress, will further clarify the associated players in this signaling pathway. Citation Format: Talita de Souza Laurentinho, Roseli da Silva Soares, Suely Kazue Marie, Sueli Mieko Oba-Shinjo. Expression profile and role of LOXL3 in astrocytomas [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 5175.
Sport concussion knowledge base, clinical practices, and needs for continuing medical education: a survey of family physicians and cross-border comparison
Authors: Constance M Lebrun, Martin Mrazik, Abhaya Prasad, B Joel Tjarks, Jason C Dorman, Michael F Bergeron, Thayne A Munce, Verle D Valentine
Journal: British Journal of Sports Medicine (2013)

Objective To identify sport concussion knowledge base, practice patterns and current/preferred methods of Knowledge Transfer and Exchange (KTE) in two distinct populations of family physicians. Design Cross-sectional study, using a survey design. Setting Alberta, Canada (CAN); North/South Dakota, USA (US). Rural (64.4% US, 27.5% CAN; p=&lt;0.001); walk-in/acute care (28.8% CAN, 12.9% US; p=0.008). Participants Recruitment: CAN physicians by mail: 80/3154 responses (2.5%); US physicians: American Academy of Family Physicians database: 109/545 responses (20%). Intervention/Instrument On-line survey questionnaire. Outcome Measures Relative percentages diagnosing/treating concussions; comparison of management strategies (including return-to-play), and current/preferred KTE. Results Etiologies: Sports/recreation (52.5% CAN); organised sports (76.5% US). Tools: Clinical examination (93.8% CAN, 88.1% US); Sport Concussion Assessment Tool (SCAT/SCAT2) (33.8% CAN, 26.7% US); balance testing (25.0% CAN, 26.7% US); concussion grading scales (26.7% US, 8.8% CAN, p=0.002); computerised neurocognitive testing (19.8% US, 1.3% CAN; p≤0.001); Standardised Assessment of Concussion (21.8% US, 7.5% CAN; p=0.008). Treatment: Physical rest (83.8% CAN, 75.5% US); cognitive rest (47.5% CAN, 28.4% US; p=0.008). Return-to-play: Clinical examination (89.1% US, 73.8% CAN; p=0.007); neurocognitive testing (29.7% US, 5.0% CAN; p≤0.001); guidelines (63.4% US, 23.8% CAN; p≤0.001). KTE sources: Colleagues (31.3% CAN, 8.8% US; p≤0.001), websites (27.5% CAN, 15.7% US; p=0.052); medical school (35.0% CAN, 12.7% US; p≤0.001). KTE Preferences: Continuing Medical Education (CME) courses (65.0% CAN, 37.3% US; p≤0.001), and online CME (47.5% Can, 29.4% US; p=0.012). Conclusions Despite evolution of concussion diagnosis/management guidelines, significant knowledge gaps exist between evidence-based recommendations clinical practice patterns. This predicates enhanced and innovative CME initiatives for KTE. Competing interests None.