tbuckley/cabot-search huggingface dataset:
STDs, IVF, and Barrier Contraception
Authors: David A. Grimes
Journal: JAMA (1987)

<h3>To the Editor.—</h3> Worldwide, approximately 5000 children have been born as the result of in vitro fertilization (IVF). In the United States alone, there are about 1 million cases of pelvic inflammatory disease each year. If we assume that 130 000 to 500 000 of these cases lead to tubal occlusion,<sup>1</sup>then in the United States alone in one month or less, pelvic inflammatory disease creates more new cases of infertility than have been successfully treated by all IVF programs in the world since Louise Brown was born in 1978. Recently, it has been demonstrated that use of condoms and spermicides reduces the risk of acquiring chlamydial infections and other sexually transmitted diseases and reduces the risk of infertility.<sup>2,3</sup>In a relatively short span of time, the active promotion of the use of condoms and spermicides to those at risk of tubal disease could prevent more cases of infertility than IVF
DENTITION.
Authors: JOSEPH CLEMENTS
Journal: JAMA (1898)

Speaking of dentition in the concrete, the importance of the subject looms up considerably when we remember that there are fifty-three dental colleges in the United States, with more than fifteen hundred graduates, interested and employed in the science and art of the care and treatment of the teeth; or in more modern terms, doctors, whose practice is limited to oral surgery. And such proportions is this assuming that ere long we shall have to add to the three learned professions—theology, medicine and law—a fourth; namely, dentistry, and the instructors in our medical colleges will have to enlarge the curriculum more fully, embracing this important branch of medical knowledge, or there will be other Edward Brannigans, D.D.S., besides the one who addressed you last year at Philadelphia, whose words will be somewhat of a reproach on our lack of this necessary knowledge. I wish here to call your attention to
Combination of gemcitabine and cisplatin (GC) chemotherapy for advanced or recurrent nasopharyngeal cancer (NPC): A phase II study
Authors: J. Kurnianda, E. Pardjono, A. Adiwiyono, I. Purwanto, B. Hariwiyanto, B. Haryadi, H. Kusumo, B. Rahardjo, J. Buter, G. Giaccone
Journal: Journal of Clinical Oncology (2004)

5577 Background : Combination of GC chemotherapy is active and has a favorable safety profile in some several solid tumors, including advanced squamous cell head and neck cancers. We evaluated the efficacy and toxicity of this combination in advanced or recurrent NPC. Methods : In a two-center phase II study, patients with histologically confirmed advanced or recurrent NPC, measurable disease, WHO PS 0–2, age 19–70 years, adequate organ function, and written informed consent, were treated with Gemcitabine 1250 mg/m2 day 1 and day 8; Cisplatin 80 mg/m2 day 1 every 3 weeks. Primary endpoint was objective response rate. Results : Thirty five patients were enrolled between 12/01 and 11/03. There were 27 male and 8 female, 33 with Javanese ethnicity and 2 Caucasian;. with a mean age was 45 years (19–68). All but 3 patients (91.4%) had undifferentiated histology. Twenty-two patients had metastatic or recurrent disease, 13 patients had locally advanced disease. All patients were chemonaive, and 10 patients had recurrent disease after radiotherapy. There were 2 complete responses and 22 partial responses, yielding an 83% overall response rate from in 29 evaluable patients (95 CI, 68% - 97%). Grade 4 liver toxicity was found in 2 of 166 (1.2%) cycles analyzed. Grade III/IV anemia, neutropenia and thrombocytopenia were found in 1.8%, 8.2% and 1.2% of cycles respectively. Two patients are still on treatment. With a median follow-up of 9 months (1–21), the median progression-free survival and overall survival are 9 and 19 months, respectively. Conclusion : Gemcitabine and cisplatin combination is effective and has a safe toxicity profile for advanced and recurrent NPC. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Elli Lily
The wild goose chase and the elephant's relevance
Authors: J. P. Kassirer
Journal: JAMA (1986)

Interpretation and incorporation of new information into our clinical practices is a critical task, particularly as the torrent of published data accelerates. In this issue ofThe Journal, a new population-based study discloses that the frequency of serious outcomes in patients with asymptomatic microscopic hematuria is small and that it increases modestly with age.<sup>1</sup>Based on these data, Mohr et al conclude that complete urologic investigation of all patients with asymptomatic hematuria is not warranted, and they propose that the prevalence of serious disease, as signaled by the patient's age and the persistence of hematuria, might be a useful guide in choosing whether to test further. For more than 25 years, I have assiduously studied patients with microscopic hematuria as defined in this study. I search several urine sediments diligently for red blood cell casts and, not finding them, proceed to carry out an intravenous urogram. I ask the
State Board Questions and Answers for Nurses
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Consequences of Selling a Kidney in India
Authors: Lyndsay S. Baines, Rahul M. Jindal
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
American Journal of Tropical Medicine &amp;amp; Hygiene, Baltimore
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Emergence of new <i>ALK</i> mutations at relapse of neuroblastoma.
Authors: Gudrun Schleiermacher, Niloufar Javanmardi, Virginie Bernard, Quentin Leroy, Julie Cappo, Thomas Rio-Frio, Gaëlle Pierron, Valérie Combaret, Frank Speleman, Anna Djos, Ingrid Ora, Fredrik Hedborg, Britt-Marie Holmqvist, Jonas Abrahamsson, Michel Peuchmaur, Jean Michon, Isabelle Janoueix-Lerosey, Per Kogner, Olivier Delattre, Tommy Martinsson
Journal: Journal of Clinical Oncology (2014)

11006 Background: The ALK receptor tyrosine kinase is activated by point mutations in neuroblastoma and constitutes a potent therapeutic target in this disease. Methods: To evaluate the role of ALK mutations in neuroblastoma progression or relapse, we searched for ALK mutations in a large series of 54 paired diagnostic–relapse neuroblastoma samples using Sanger sequencing. When an ALK mutation was observed in one sample, deep sequencing was used to seek for a minor mutated component in the other sample. With a coverage of > 100,000, the background variability was 0.034% per base at each position, resulting in a sensitivity to detect low frequency mutations in 0.15%. Results: Among the paired samples, all 9 ALK-mutated cases at diagnosis demonstrated the same mutation at relapse by Sanger sequencing. Nevertheless, in one case, the mutation was detected in only one of several nodules at relapse. In contrast, in 5 cases, the mutation appeared relapse-specific. Among these, 4 cases could be further investigated by deep sequencing. In two cases no evidence of the mutation was observed at diagnosis. In one case, the mutation occurring at relapse could be identified at a sub-clonal level at diagnosis, whereas in another case, two different mutations resulting in identical amino acid changes could be detected at diagnosis and relapse. Further evidence of clonal evolution of ALK-mutated cells was provided by the observation of a minor ALK-mutated cell population in a tumour from which a cell line with ALK mutation in all cells was derived. Conclusions: These results indicate that, in neuroblastoma, ALK mutations newly detected at the time of relapse can be present in a subclone at the time of diagnosis with subsequent clonal expansion at relapse. With the advent of targeted therapy using ALK inhibitors, precise knowledge of the ALK status is mandatory. Our observation of a significant spatio-temporal variation of ALK mutations is of utmost importance in clinical practice, highlighting the potential of NGS and the importance of serial samplings for therapeutic decisions.
Ultraviolet cystoscopy
Authors: W. F. Whitmore
Journal: JAMA (1968)

It is well recognized that the actual onset of malignant change may antedate by a considerable time the first identifiable morphologic manifestations of neoplasm and that the latter in turn may precede the first symptomatic manifestations of the process. Even after the appearance of symptoms, the interval before the specific diagnosis is accurately made may be long—a possibility for which the site and nature of the malignant change, the patient, and the physician share varying degrees of responsibility. Furthermore, the presence of a clinically obvious neoplasm at one site in a tissue or organ is often associated with an increased probability of coexistent neoplastic change at other sites in the respective organ or tissue. These generalizations relative to tumor behavior have specific application in the case of neoplasms of the human bladder. The possibility that cancer of the bladder may have a preclinical phase has been overshadowed by the facts
Respiratory Research's Reach
Authors: Mike Mitka
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Baroreflex Dysfunction
Authors: Horacio Kaufmann, Lucy Norcliffe-Kaufmann, Jose-Alberto Palma
Journal: New England Journal of Medicine (2020)

Baroreflexes play both an adaptive and a homeostatic role, maintaining blood pressure, heart rate, and blood volume within the normal range. Defects in baroreflexes have diverse manifestations and causes. The assessment and management of baroreflex dysfunction are reviewed.
American health care system management objectives. The aura of inevitability becomes incarnate
Authors: G. D. Lundberg
Journal: JAMA (1993)

It is the most difficult and complicated set of challenges that the United States has faced since the Great Depression; to some it seems the moral equivalent of World War II; it will last longer, be more expensive, and stands a chance of being more divisive than the Vietnam War; it intimately involves every inhabitant of our country; it holds hostage the future of what many consider history's greatest profession; it may well determine the success or failure of a president and a federal administration. It is American health care system reform in 1993. We've come such a long way since<i>JAMA</i>began its series "Caring for the Poor" in December 1987. Much of our world changed its attitude when in May 1991, invoking the reformist spirit of Abraham Lincoln,<i>JAMA</i>and our nine specialty journals published literally hundreds of pages on national health care reform.<sup>1,2</sup>For the first
Long-term outcome of patients with versus without diabetes mellitus in the DESTINI trial Issam Moussa, Antonio Colombo, Carlo Di Mario, Yoshio Kobayashi, Milena Adamian, Roxana Mehran, Edward M. Kreps, Hassan Faraj, Alexandra J. Lansky, Michael B. Collins, George Dangas, Jeffrey W. Moses, On Behalf of the DESTINI-CFR Study Group. Lenox Hill Heart and Vascular Institute, New York, NY, Centro Cuore Columbus, Milan, Italy
Journal: Journal of the American College of Cardiology (2001)
Medicine and the computer. VII. Better basis for management decisions.
Journal: BMJ (1968)

the ideal person to do this is the family doctor with his ancillary staff, and patients seem to agree.The talks can be designed to fit the team's method of working, and can provide useful two-way communication between doctor and patient that is more informal than the consulting-room relationship.Groups larger than 25 to 30 do not seem to hinder discussion.Our only expenses were stationery, postage, and photo- graphic materials, which were generously met by three drug firms.If, however, it is Ministry of Health policy to provide health education, then it would seem reasonable that expenses be met from its funds.In my opinion there is a great need for more modern and varied health education films and filmstrips.Many of the films are hopelessly out of date.I should like to thank Dr.
Pediatric Surgery
Authors: Marc I. Rowe
Journal: JAMA (1987)

<h3>To the Editor.—</h3> In his review of the two-volume text<i>Pediatric Surgery</i>, Dr Burrington<sup>1</sup>criticizes the chapter I wrote on necrotizing enterocolitis by stating that it had an omission, ie, it "does not mention the high association of rotavirus with necrotizing enterocolitis." Please look at page 948 in the chapter on necrotizing enterocolitis. The association of viruses, including rotaviruses, with necrotizing enterocolitis is, I believe, adequately covered in a paragraph and highlighted by three references. A report of an outbreak of necrotizing enterocolitis associated with rotavirus infection is detailed. It would appear to me that the reviewer should carefully check the text before allowing his comments to be published in a journal as reputable as<i>JAMA</i>.
THE BASAL METABOLISM IN EMOTIONAL STATES
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Strange bedfellows.
Authors: S M Grunberg
Journal: Journal of Clinical Oncology (1996)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1996.14.3.1042 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 8622010 Strange bedfellows. S M GrunbergxS M GrunbergSearch for articles by this author https://doi.org/10.1200/JCO.1996.14.3.1042 PDF "Strange bedfellows.." Journal of Clinical Oncology, 14(3), pp. 1042–1043© 1996 by American Society of Clinical Oncology
AMYL NITRITE IN HEMOPTYSIS.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prevalence, risk factors, and genotype distribution of hepatitis C virus infection in the general population: A community-based survey in southern Italy
Authors: V Guadagnino
Journal: Hepatology (1997)

In 1996 the prevalence, risk factors, and genotype distribution of hepatitis C virus (HCV) infection were assessed in the general population of a town in southern Italy. The sample was selected from the census by a systematic 1:4 sampling procedure. The participation rate was 96.6%. Among the 1,352 subjects enrolled, 195 (14.4%) tested reactive to antibody to HCV (anti-HCV) with enzyme immunoassay (EIA 3). When further tested with recombinant immunoblot assay (RIBA 3), 170 subjects (87.2%) tested positive, 23 subjects (11.8%) had indeterminate results, and 2 subjects (1%) tested negative. Thus, the overall anti-HCV EIA-positive RIBA-confirmed prevalence was 12.6% (170 of 1,352 subjects) and increased from 1.3% in subjects younger than 30 years to 33.1% in those ≥ 60 years of age. This latter age group accounted for 72.3% of all anti-HCV-positive subjects. Females tested positive more frequently than males (14.1% vs. 10.5%; P < .05). Alanine transaminase (ALT) concentrations were abnormal in only 4.1% (7/170) of anti-HCV EIA-positive RIBA-confirmed subjects. This suggests that ALT screening is not useful in the detection of anti-HCV-positive subjects in a general population. The results of multiple logistic regression analysis showed that an age of less than 45 years, the use of glass syringes, and dental therapy were all independent predictors of anti-HCV positivity. HCV RNA was detected by polymerase chain reaction in 75.9% of the 195 anti-HCV EIA-positive subjects: in 84.7% (144/170) of the RIBA-confirmed subjects; in 17.4% (4/23) tested as RIBA indeterminate; and in neither of the two subjects who tested RIBA negative. HCV type 1b was detected in 75 subjects (50.7%), type 2b in 1 subject (0.7%), type 2c in 66 subjects (44.6%), type 3a in 4 subjects (2.7%), and type 4 in two subjects (1.3%). These figures differ from those of Italian patients with chronic liver disease in whom genotype 2 is more rare. None of the individuals was infected with more than one genotype. The distribution of the two most common HCV viral types (1b and 2c) was not statistically different in terms of mean age, sex, or risk factors and suggests that they may have had a parallel spread in this community. These findings provide one of the highest overall anti-HCV prevalence rates in a general population with a likely cohort effect, i.e., decreased risk of infection along generations. These observations may indicate an epidemic or focus of hepatitis C that occurred several years earlier. The majority of anti-HCV–positive subjects in the oldest age group and with no clinical evidence suggests that HCV infection is a very prolonged and indolent disease.