tbuckley/cabot-search huggingface dataset:
Antihypertensive Therapy
Authors: R E Schmieder, R Veelken
Journal: JAMA (1991)

The benefits of continuous antihypertensive therapy have been extensively documented. However, lack of compliance with the prescribed regimen, excessive cost, and troublesome adverse effects of some antihypertensive agents led to the consideration of intermittent therapy or even complete discontinuation of therapy as an effective alternative to lifelong medication. Prospective studies dealing with this subject reported inconsistent results. Nevertheless, they allowed us to identify selection criteria of candidates for step-down or discontinuation of antihypertensive therapy. Such candidates include patients with mild essential hypertension who have one or more of the following characteristics: young age, normal body weight, low salt intake, no alcohol consumption, low pretreatment blood pressure, successful therapy with one drug only, and no or only minimal signs of target organ damage. Stopping antihypertensive therapy without subsequent rise in arterial pressure was shown to be possible in a subset of patients with mild essential hypertension for a period of months to years. This approach appears to be safe, provided that blood pressure is monitored frequently, and may improve compliance, save treatment costs, and reduce adverse effects of certain drugs, although its long-term consequences for morbidity and mortality remain to be determined. (<i>JAMA</i>. 1991;265:1566-1571)
Authors' reply
Authors: S T O'Keeffe, J J Gilmartin
Journal: Thorax (2010)

with regard to disclosure of serious or risks which was tailored in the majority if the patient underwent transbronchial biopsy (figure 1).Particular risks were represented in terms of an exact percentage in 15 and in 6 by means of words (eg, occasional, common).Fifteen respondents tailored their consent in the presence of significant co-morbidity.Risk of death was communicated always by 3 respondents, often by 1, sometimes by 15 and never by 14.The current British Thoracic Society guidance on consent for bronchoscopy from 2001 2 reflected the legal and ethical standard at that time where doctors were "entitled to withhold information" if it was thought to be detrimental to patient health and were under "no duty .to point out remote risks".The ethicolegal landscape has been changed dramatically by rulings such as Chester v Afshar, 3 and this is reflected in the recent General Medical Council publication on consent 4 which states that a doctor "must tell patients if an investigation or treatment might result in a serious adverse outcome, even if the likelihood is very small".We feel that all patients with capacity undergoing bronchoscopy should be offered detailed risk disclosure with documentation of the decision in those patients wishing to "opt out", and that this risk information should become standardised and individually tailored where possible.
P43 * FSTL5 EXPRESSION IS A MARKER OF GROUP C IN METASTATIC MEDULLOBLASTOMAS
Authors: C. Baldi, S. Minasi, F. Gianno, F. Giangaspero, M. Massimino, F. R. Buttarelli
Journal: Neuro-Oncology (2014)

INTRODUCTION: Medulloblastoma (MB) is the most common malignant brain tumor in children. Four different molecular subgroups are recognized, which differ in gene expression, genomic aberrations, histology, demographics and survival: WNT and SHH groups, having specific mutations in the homonymous pathway, and groups C and D having several genetic alternations not specific to a single pathway. The gene for follistatin-like protein 5, FSTL5, is overexpressed in nonSHH/nonWNT MBs poorly characterized. High-expression of FSTL5 is significantly associated with reduced event-free and overall survival in non-WNT/non-SHH MBs. The major aim of this project is to study the FSTL5 expression level in pediatric MBs with metastasis at the onset. METHOD: We investigated the protein expression of biomarkers involved in metastatic pathways by IHC and FSTL5 expression level by RT-PCR in 26 metastatic MBs samples and correlated these data with the outcomes by Kaplan-Meier statistic analysis. RESULTS: 83% of Group C MBs showed high level of FSTL5 while none of these presented down-expression. Low-expression level of FSTL5 was find in 60% of SHH MBs and none showed over-expression. Kaplan-Meier test revealed that, in our cohort, high-expression of FSTL5 did not correlate with worse outcome while low expression of FSTL5 was associated with good prognosis and the co-presence of FSTL5 with other biomarkers correlated with poorer prognosis. CONCLUSION: FSTL5 is a marker of Group C in medulloblastomas with metastasis at the onset and the results highlighted decreased FSTL5 expression as a marker of good prognosis. Group C MBs have characteristic molecular features that confirm the poorest outcome also in MBs with metastasis at the onset.
Sketch of the History of the Mayo Clinic and the Mayo Foundation.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Epiglottis Retractor.
Authors: SETH SCOTT BISHOP
Journal: JAMA (1900)

The accompanying figure illustrates an epiglottis retractor designed for use in cases in which it is impossible to obtain a good view of the interior of the larynx without holding the epiglottis upward and forward. The spade-like blade which rests on the posterior or under surface of the epiglottis is sufficiently wide to produce a certain degree of a flattening effect on an omega-shaped epiglottis, thus facilitating laryngoscopy in two ways. A firm control over the retractor is given by the employment of the double-ring handle, such as is used in the biting forceps.
Single-antibiotic therapy for streptococcal endocarditis
Authors: A. W. Karchmer
Journal: JAMA (1979)

Ninety-nine patients treated with penicillin G potassium, cephalothin sodium, or vancomycin hydrochloride were studied to evaluate single-drug therapy for nonenterococcal streptococcal endocarditis. Eighty-six patients survived; of these, 66 received penicillin alone. The maximum serum bactericidal titer obtained at the expected nadir of serum antibiotic concentration was 1:8 or greater in 70 (95%) of the 74 patients studied. No relapse occurred among the 66 patients treated with penicillin. Only one patient experienced a relapse that occurred following therapy with suboptimal doses of vancomycin. Distinct second episodes of endocarditis occurred in five patients. While 13 patients died, none died of intractable infection. The treatment of endocarditis due to penicillin-susceptible streptococci with high-dose parenteral penicillin or a bactericidal penicillin substitute for four weeks or longer results in bacteriologic cure rates comparable with those achieved with combined penicillin-streptomycin regimens. (<i>JAMA</i>241:1801-1806, 1979)
POISONING BY WOOD ALCOHOL.CASES OF DEATH AND BLINDNESS FROM COLUMBIAN SPIRITS AND OTHER METHYLATED PREPARATIONS.
Authors: FRANK BULLER
Journal: JAMA (1904)

<h3>(A.) PUBLISHED CASES OF WOOD-ALCOHOL POISONING.</h3> The following tables, prepared by Dr. Buller, are practically complete to June, 1904. As previously stated, they furnish characteristic accounts of intoxication from various methylated drinks, as well as from inhalation of the vapor of methyl alcohol. That only two of these cases occurred in Europe points the moral so often urged in these papers; wherever a government permits the sale of "deodorized" wood alcohol (as in the case of Columbian spirits in the United States and standard wood spirits in Canada), the only effective safeguard against the ingestion of the poison is removed and the annual sacrifice to death and blindness will certainly continue. Either the manufacture and sale of "deodorized" wood spirit should be absolutely prohibited, or, as in Germany and Great Britain, an untaxed ethyl alcohol, rendered undrinkable by the addition of pyroligneous spirit, mineral oil, naphthalin or some other nauseous
Pediatric vaccine tax seeks to cover injury; not all manufacturers passing on increase
Authors: C. Marwick
Journal: JAMA (1988)

THE COST OF PEDIATRIC immunization is soaring. The price of the routine five doses of the diphtheria-tetanus-pertussis (DTP) vaccine has gone from around $44 to around $55—a 25% increase. The cost of the combined measles-mumps-rubella (MMR) vaccine has gone up from $20.72 per dose last year to $27.23—a 30% increase. Part of this rise is due to price increases by manufacturers, but the main reason is that Congress has finally funded and the President signed into law the National Childhood Vaccine Injury Act. The legislation levies a tax on pediatric vaccines to cover the cost of compensation for any vaccine injury. The tax took effect at the beginning of the year. The DTP vaccine carries a tax of $4.56 per dose; MMR, $4.44 per dose; diphtheria-tetanus, 6 cents per dose; and polio, 29 cents per dose. The amount of the tax is based on the estimate of the risk of
TRAVEL NOTES FROM SOUTH AMERICA.
Authors: NICHOLAS SENN
Journal: JAMA (1907)

<h3>VI. *THE HOSPITALS OF BUENOS AIRES.</h3> The many hospitals of Buenos Aires, its numerous homes for infants, orphans, the aged poor and helpless, its leagues against tuberculosis and alcoholism, its excellent Red Cross organization, all combine to show that the Argentines possess a charitable disposition toward the sick and poor, and that they have grasped the fundamental idea that prevention is better than cure and that prophylactic medicine is the medicine of the future. The state lottery, an institution that would not be tolerated in our country, furnishes the major part of the contributions which support the many charitable institutions; 25 per cent. of the income of this wheel of fortune is set aside and applied to the support of charitable institutions. Buenos Aires has more than its good share of hospitals where the sick poor find the doors wide open for their reception, care and treatment. The following is
Archives of Internal Medicine, Chicago
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Decision Analysis
Authors: Emmett Keeler
Journal: JAMA (1977)

<h3>To the Editor.—</h3> The article entitled "Clinical Decision Analysis: The Hazard of Using Additional Data" (236:1259, 1976) suggests that costless, risk-free information can make patient care worse rather than better. In fact, properly used free information can never make any decision worse—the decision-maker can always ignore it (Raiffa,<i>Decision Analysis</i>, 1968). The examples given in the article actually make two different but important common-sense points. First, even if a test result favors a certain diagnosis, one shouldn't act as if the diagnosis is certain. Second, a test has diagnostic value only when some conceivable result of that test will alter treatment. In both examples in the article, the test is not discriminating enough to alter treatment if the results are properly weighed. For example, in the case of bronchogenic cancer, 20% of patients are assumed to have undetected metastases, and a liver scan is assumed to have a probability of
Abstract 11668: High Resolution Magnetocardiography as a Novel Noninvasive Tool to Distinguish Between Benign and Malignant Early Repolarization Pattern
Authors: Naotsugu Iwakami, Takeshi Aiba, Hiroshi Takaki, Tsukasa Kamakura, Mitsuru Wada, Kohei Ishibashi, Ikutaro Nakajima, Koji Miyamoto, Yuko Y Inoue, Hideo Okamura, Satoshi Nagase, Takashi Noda, Kengo Kusano, Satoshi Yasuda, Hisao Ogawa, Masaru Sugimachi, Shiro Kamakura
Journal: Circulation (2015)

Introduction: Most of the early repolarization patterns (ERP) in electrocardiography (ECG) are benign but some of them are associated with ventricular fibrillation (VF). We evaluated whether or not a high spatio-temporal resolution magnetocardiography (MCG) could non-invasively detect malignant types of ERP. Methods: Sixty four-channel MCG, standard 12-lead ECG, and signal averaged ECG (SAECG) were recorded in 120 patients with inferolateral ERP in ECG without any major structural heart diseases; 13 of them had a history of VF (VF(+)-group) and the remaining 107 had no VF (VF(-)-group). We evaluated the following novel MCG indexes: MCG-QRS (msec), root mean square of terminal 40 msec magnetic field (MCG-RMS) (msec), and the duration under 10% of maximal amplitude (MCG-LAS) (msec) of the highest amplitude channel. Results: The amplitude and distribution of the J-wave, ST-T morphology in ECG, parameters of SAECG were not significantly different, whereas MCG-QRS and MCG-LAS were significantly longer and MCG-RMS was smaller in ERP-VF(+) compared with ERP-VF(-) group (107(SD=24) vs 84(13) msec, P&lt;0.01, 8(22) vs 22(11) msec, P&lt;0.01, 0.10(0.08) vs 0.28(0.19) msec, P&lt;0.01, respectively). In the multivariate logistic regression model, only MCG-QRS remained significant among the MCG indexes and the existing predictors (odds ratio (OR) 1.08, 95%CI 1.01 to1.17). The predictive ability of VF was significantly higher using MCG-QRS when the c-statistic was compared with that of the existing ECG measure (0.82 vs 0.56, P&lt;0.01, Figure). When cut-offs were set by the least squares method at MCG-QRS 100 msec, MCG-RMS 0.24 msec, MCG-LAS 27 msec, corresponding ORs were calculated as 12.7, 95%CI 3.6 to 45.0, 6.1, 95%CI 1.7 to 21.2, 6.2, 95%CI 1.8 to 20.8, respectively. Conclusions: MCG-QRS &gt;100 msec was a simple and effective criterion for prediction of high risk ERP subjects, thus MCG analysis is an useful screening tool to detect malignant ERP out of the numerous benign ones.
BOOKS REVIEWS
Authors: M. S. Simon
Journal: JNCI Journal of the National Cancer Institute (1992)

Journal Article BOOKS REVIEWS Get access Breast Cancer Treatment: A Comprehensive Guide to Management Barbara Fowble , Robert L. Goodman , John H. Glick , Ernest F. Rosato , St. Louis : Mosby-Year Book , 1992 . 647 pp., illus. $89 Michael S. Simon Michael S. Simon Division of Hematology and Oncology Wayne State University School of Medicine3990 John R. Street Detroit, MI 48201 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 84, Issue 12, 17 June 1992, Page 975, https://doi.org/10.1093/jnci/84.12.975 Published: 17 June 1992
Update in Gastroenterology
Authors: Norton J. Greenberger
Journal: Annals of Internal Medicine (2003)

Updates from the Annual Session7 January 2003Update in GastroenterologyNorton J. Greenberger, MDNorton J. Greenberger, MDFrom Brigham and Women's Hospital, Boston, Massachusetts.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-138-1-200301070-00011 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail This Update summarizes important advances reported in the past 2 years on the management of digestive disorders. I discuss clinical problems that practicing internists commonly encounter and cover new developments in areas frequently discussed in the gastroenterology literature. I have divided the Update into sections on gastroesophageal reflux disease, Helicobacter pylori infection, infectious diarrhea, colorectal cancer screening, gastrointestinal bleeding, and inflammatory bowel disease.Gastroesophageal Reflux DiseaseGastric Acid Pocket Bathes Gastroesophageal JunctionThe following study of the pathophysiology of the gastroesophageal junction explains in part why the junction is so susceptible to injury and why symptoms of acid injury occur after ...References1. Lau JY, Sung JJ, Lee KK, Yung MY, Wong SK, Wu JC, . Effect of intravenous omeprazole on recurrent bleeding after endoscopic treatment of bleeding peptic ulcers. N Engl J Med. 2000;343:310-6. [PMID: 10922420] CrossrefMedlineGoogle Scholar2. Asaka M, eds. Gastric Cancer, Helicobacter pylori, and Gastroduodenal Diseases. Tokyo: Sentan Igakasha; 1999:116-26. Google Scholar Author, Article, and Disclosure InformationAffiliations: From Brigham and Women's Hospital, Boston, Massachusetts.Corresponding Author: Norton J. Greenberger, MD, Division of Gastroenterology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115; e-mail, [email protected]org. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByEvidence-Based Recommendations for Older Adults With Helicobacter pylori or Those Using Nonsteroidal Anti-Inflammatory Drugs 7 January 2003Volume 138, Issue 1Page: 45-53KeywordsArteriovenous malformationColitisColorectal cancerDiarrheaDysplasiaGastroesophageal reflux diseaseHemorrhageSurgeryToxinsUlcers ePublished: 7 January 2003 Issue Published: 7 January 2003 CopyrightCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Increase in Pneumonia Mortality Among Young Adults and the HIV Epidemic— New York City, United States
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ERYTHEMA PERSTANS
Authors: JOHN W. WHITE, HAROLD O. PERRY
Journal: British Journal of Dermatology (1969)

Journal Article ERYTHEMA PERSTANS Get access JOHN W. WHITE, JOHN W. WHITE Mayo Clinic and Mayo Foundation: Section of Dermatology (Dr. Perry). Mayo Graduate School of Medicine (University of Minnesota), Rochester: Resident in Dermatology (Major White) Search for other works by this author on: Oxford Academic Google Scholar HAROLD O. PERRY HAROLD O. PERRY Mayo Clinic and Mayo Foundation: Section of Dermatology (Dr. Perry). Mayo Graduate School of Medicine (University of Minnesota), Rochester: Resident in Dermatology (Major White) Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 81, Issue 9, 1 September 1969, Pages 641–651, https://doi.org/10.1111/j.1365-2133.1969.tb16202.x Published: 01 September 1969 Article history Accepted: 29 January 1969 Published: 01 September 1969
AMEBIC APPENDICITIS.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cryosurgery in cutaneous leishmaniasis
Authors: Ahmed Bassiouny
Journal: British Journal of Dermatology (1983)

Journal Article Cryosurgery in cutaneous leishmaniasis Get access Ahmed Bassiouny Ahmed Bassiouny Dept. of Otolaryngology, Fakhry Hospital, Alkhobar, Saudi Arabia Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 109, Issue 5, 1 November 1983, Pages 617–619, https://doi.org/10.1111/j.1365-2133.1983.tb07689.x Published: 01 November 1983
Acquired factor X deficiency. Altered plasma antithrombin activity and association with amyloidosis
Authors: P. A. Galbraith
Journal: JAMA (1974)

Isolated factor X deficiency in association with abnormal plasma antithrombin activity was recognized in a 59-year-old man with amyloidosis and signs and symptoms of calf pain suggestive of thrombophlebitis. Venographic studies excluded venous thrombosis, and, despite major coagulation abnormalities, there was no hemorrhagic tendency. Infusion of plasma at maximum tolerable volume did not result in a rise in factor X activity, nor in alteration in antithrombin activity. The latter abnormality appears to be unique and, to our knowledge, has not been reported previously in association with amyloidosis. (<i>JAMA</i>230:1658-1660, 1974)