tbuckley/cabot-search huggingface dataset:
Lawyer control of the tobacco industry's external research program. The Brown and Williamson documents
Authors: L. Bero
Journal: JAMA (1995)

<h3>Objective.</h3> —To examine the involvement of tobacco industry lawyers in the selection of tobacco industry scientific research projects and to examine how the research was used to influence public policy. <h3>Data Sources.</h3> —Documents from Brown and Williamson Tobacco Corporation, the British American Tobacco Company (BAT), and other tobacco interests provided by an anonymous source, obtained from Congress, and received from the private papers of a former BAT officer. <h3>Study Selection.</h3> —All available materials, including confidential reports regarding research and internal memoranda exchanged between tobacco industry lawyers. <h3>Conclusions.</h3> —The involvement of tobacco industry lawyers in the selection of scientific projects to be funded is in sharp contrast to the industry's public statements about its review process for its external research program. Scientific merit played little role in the selection of external research projects. The results of the projects were used to generate good publicity for the industry, to deflect attention away from tobacco use as a health danger, and to attempt, sometimes surreptitiously, to influence policymakers. (<i>JAMA</i>. 1995;274:241-247)
Contents
Authors: C Toso, G Mentha, P Majno, F Saliba, D Samuel, M Sprinzl, P Galle, E Lawitz, M Rodriguez-Torres, A Stoehr, E Gane, L Serfaty, S Bhanja, R Barnard, D An, J Gress, P Hwang, N Mobashery, F Poordad, K Kowdley, D Cohen, T Podsadecki, S Siggelkow, L Larsen, R Menon, G Koev, R Tripathi, T Pilot-Matias, B Bernstein, W.-H Wen, M.-H Chang, L.-L Zhao, Y.-H Ni, H.-Y Hsu, J.-F Wu, P.-J Chen, D.-S Chen, H.-L Chen, M Silva, M Treitel, D Graham, S Curry, M Frontera, P Mcmonagle, S Gupta, E Hughes, R Chase, F Lahser, A Howe, J Howe, G Pells, G Mells, M Carbone, J Newton, A Bathgate, A Burroughs, M Heneghan, J Neuberger, D Day, S Ducker, Uk-Pbc Consortium, R Sandford, G Alexander, D Jones, W Bernal, A Hyyrylainen, A Gera, V Audimoolam, M Mcphail, G Auzinger, M Rela, N Heaton, J Oõgrady, J Wendon, R Williams, B Sangro, C Gomez-Martin, M De La Mata, E Garralda, P Barrera, J Riezu-Boj, E Larrea, C Alfaro, P Sarobe, J Lasarte, J Pe ´rez-Gracia, I Melero, J Prieto, M Pompili, A Saviano, N De Matthaeis, A Cucchetti, F Ardito, B Federico, F Brunello, A Pinna, A Giorgio, S Giulini, I De Sio, G Torzilli, F Fornari, L Capussotti, A Guglielmi, F Piscaglia, L Aldrighetti, E Caturelli, F Calise, G Nuzzo, G Rapaccini, F Giuliante
Journal: Journal of Hepatology (2013)
P08.59 Redefining the cellular architecture of adult and pediatric glioblastomas through large-scale single-cell analyses
Authors: M. G. Filbin, I. Tirosh, V. Hovestadt, D. N. Louis, I. Slavc, K. Ligon, T. Golub, B. Bernstein, A. Regev, M. L. Suva
Journal: Neuro-Oncology (2017)

While human tumors are shaped by the genetic evolution of cancer cells, evidence also suggests that they display superimposed hierarchies reminiscent of normal development. Yet, relating the genetic and hierarchical models of cancer organization has been limited by technical challenges. Here, studying hemispheric and midline pediatric and adult glioblastomas, we profiled thousands of single cells from fresh tumors by RNA-seq and reconstructed the genetic and epigenetic cellular architecture of tumors in patients. We identified that most cancer cells are differentiated along specialized glial programs, while a subpopulation of cells are undifferentiated and associated with neural stem cell expression programs. By identifying distinct genetic clones, we show that these cellular architectures evolve during the progression of the tumors, suggesting that developmental programs and genetic influences coordinately determine tumor architecture. These results provide unprecedented insight into the cellular composition of brain tumors at single-cell resolution and may help harmonize the cancer stem cell and the genetic models of cancer, with critical implications for disease management.
κ Light Chains in Spinal Fluid for Diagnosing Multiple Sclerosis
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Report of the Special Task Force on Professional Liability and Insurance and the Advisory Panel on Professional Liability
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Classification of Carcinoid Tumors
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
England is in a sexual health crisis, MPs say
Journal: BMJ (2003)

lesion.Despite these differences, there is no obvious explanation for the discrepancy.We had few eligibility criteria that would limit the external validity of the study.GPs particularly interested in skin lesions may have been more likely to participate, but the ratios that we observed were similar to that found in an analysis of all excisions sent to a pathology service in Victoria. 5 GPs in Australia practise on a fee for service basis, and excisions of malignant skin lesions attract a higher payment than excisions of benign skin lesions.In conclusion, our results do not show that photography of pigmented skin lesions in general practice in Australia decreases the number of benign lesions excised without compromising sensitivity of the diagnosis of melanoma.
Evaluation of a worldwide spontaneous reporting system with cimetidine
Authors: T. G. Davis
Journal: JAMA (1980)

Adverse reactions to cimetidine have been identified through the manufacturer's Worldwide Spontaneous Reporting System. Reactions not observed during clinical trials—mental confusion, interstitial nephritis, and potentiation of oral anticoagulants—were identified and added to the prescribing information for cimetidine while further studies were undertaken. The monitoring of the drug's adverse reaction profile is ongoing so that new types of reactions can be identified. (<i>JAMA</i>243:1912-1914, 1980)
Occupational asthma.
Authors: M Chan-Yeung
Journal: Environmental Health Perspectives (1995)

Many toxic compounds found in air emissions may induce bronchoconstriction. In the workplace, workers are exposed to these compounds, often in much higher concentrations. Some of these compounds act as sensitizers. Of these, some compounds induce asthma by producing specific IgE antibodies to the compound or its protein conjugate, while others induce asthma through yet unidentified immunologic mechanisms. Some compounds, when inhaled in high concentrations, act as irritants and produce bronchoconstriction probably by inducing acute airway inflammation. The latter condition is called Reactive Airways Dysfunction Syndrome (RADS) or irritant-induced asthma. Occupational asthma is an excellent model to study the pathogenesis and the natural history of adult onset asthma because the responsible agent can be identified, complete avoidance is possible, and exposure can be measured or estimated.
"Neo-Listerism"
Authors: A. W. Fowler
Journal: BMJ (1965)

The Oxford series suggests strongly that this excess is largely concentrated in the first two years of the disease, but this is not supported by the Christie data.Effusions arising from haematogenous spread should arise equally often on either side, so that the excess of ipsi- lateral effusions suggests another mode of spread.This other mode of spread is pre- sumably permeation of the chest-wall, the tumour invading inwards towards the pleura rather than outwards towards the skin.Prompt and energetic treatment of the chest- wall after mastectomy, especially in stage II, may be worth while, even at the risk of a minor degree of lung fibrosis.-Iam, etc.,
Continuous increase of alcohol dehydrogenase activity along the liver plate in normal and cirrhotic human livers
Authors: E Sokal
Journal: Hepatology (1993)

To determine the zonal distribution of alcohol dehydrogenase in normal and cirrhotic human livers, we measured activities of this enzyme by quantitative cytochemical analysis along the liver cell plate in liver specimens from 10 normal organ donors and from 7 children with extrahepatic biliary atresia cirrhosis. In normal human liver samples, a continuous increase in alcohol dehydrogenase activity was observed along the sinusoid from the periportal to the perivenular hepatocytes (mean extinction units from 16.2 ± 10.0 to 58.0 ± 14.8). A similar observation was made in cirrhotic nodules, with activity increasing continuously from nodule periphery to center (7.6 ± 4.1 to 44.9 ± 13.3). This study demonstrates a heterogeneous pattern of alcohol dehydrogenase distribution along the sinusoid in normal human liver specimens. In addition, demonstration of this heterogeneity in human cirrhosis suggests that the cirrhotic liver is able to maintain a parenchymal functional organization, with persistence of metabolic zonation. (HEPATOLOGY 1993;17:202–205.)
Staphylococcal Tricuspid Endocarditis in Heroin Addicts.
Authors: R. A. Olsson
Journal: Annals of Internal Medicine (1962)

s1 April 1962Staphylococcal Tricuspid Endocarditis in Heroin Addicts.R. A. Olsson, M.D., M. J. Romansky, M.D., F.A.C.P.R. A. Olsson, M.D.Search for more papers by this author, M. J. Romansky, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-56-4-670_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSix patients with staphylococcal endocarditis secondary to heroin addiction are presented, bringing the total number of reported cases to 16.Septic pulmonary embolism dominated the clinical course in all patients. Transient murmurs of tricuspid insufficiency were heard in two patients. One other patient developed a loud murmur of tricuspid insufficiency along with other phyiscal signs of this lesion. Cardiac findings in the remaining patients were non-specific or absent. Five of the six patients had episodes suggesting renal embolization; two patients had retinal emboli.Chest X rays revealed numerous bilateral densities which, in four patients, progressed to cavitation. The cavities ultimately... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Washington, D. C. (CS) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1962Volume 56, Issue 4Page: 670-670KeywordsAddictsEndocarditisHeroinLesionsPulmonary embolismThorax Issue Published: 1 April 1962 PDF DownloadLoading ...
Regression of pituitary prolactinoma with bromocriptine administration
Authors: C. Velentzas
Journal: JAMA (1981)

IT HAS been demonstrated that treatment with bromocriptine mesylate can reduce the size of pituitary prolactinomas.<sup>1,2</sup>The actual mechanism by which this is achieved remains obscure, although bromocriptine has been shown to reduce the mitotic rate of the tumor in rats.<sup>3</sup>In man, bromocriptine, an ergot derivative and dopamine agonist, has a potent inhibitory action on prolactin secretion and, in patients with hyperprolactinemia, it lowers serum prolactin levels and restores gonadal function.<sup>1</sup> We treated a patient with a sizeable pituitary prolactinoma with bromocriptine alone. A remarkable reduction of the tumor size was achieved in addition to the reversal of the biochemical features. <h3>Report of a Case</h3> A 20-year-old man was referred to us for further investigation of hypogonadism and occasional diplopia, which occurred on his looking to the left. His medical history revealed that he had not yet reached puberty and libido was absent. Otherwise, his medical
The Parenteral Use of Vitamin Preparations
Authors: Franz J. Ingelfinger
Journal: New England Journal of Medicine (1945)

IN 1943 the National Research Council1 published what it considered to be adequate daily allowances of the better known vitamins. Although the recommended amounts have been attacked as too large from the viewpoint of minimum requirements, these allowances, which admittedly include a factor of safety of at least 30 per cent,2 provide physicians with standards concerning the vitamins a normal person should ingest. The field of parenteral vitamin therapy, by contrast, appears to be one of hopeless confusion. Parenteral vitamin preparations of all types are, literally and figuratively, a drug on the market, but information concerning their proper use is . . .
MILK MIXTURES FOR INFANT FEEDING
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ELIMINATION OF TOXINES IN ENTERIC FEVER.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Book Listings
Journal: Annals of Internal Medicine (2002)

Book Listings19 February 2002Book ListingsSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-136-4-200202190-00019 SectionsAboutFull Text ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Cardiology100 Questions in CardiologyD Holdright and H Montgomery, eds. 222 pages. London: BMJ; 2001. $42.00. ISBN 0727914898. Order phone 011-44-171-387-4499.ABC of Hypertension4th edition. G Beevers, GY Lip, and E O'Brien. 108 pages. London: BMJ; 2001. $25.00. ISBN 0727915223. Order phone 011-44-171-387-4499.Advances in the Treatment of Atrial Tachyarrhythmias: Pacing, Cardioversion, and DefibrillationCW Israel and S Barold, eds. 446 pages. Armonk, NY: Futura; 2002. $127.00. ISBN 0879934972. Order phone 800-877-8761.Cardiac Arrhythmias after Surgery for Congenital Heart DiseaseS Balaji, PC Gillette, and CL Case, eds. 360 pages. Boston: Arnold; 2001. $99.00. ISBN 0340762071. Order phone 800-368-5777.Cardiac Pacing and ... Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 19 February 2002Volume 136, Issue 4Page: B1 ePublished: 19 February 2002 Issue Published: 19 February 2002 CopyrightCopyright © 2002 by American College of Physicians. All Rights Reserved.Loading ...
Book Review Manual of Dermatology . Issued under the auspices of the Committee on Medicine of the Division of Medical Sciences on the National Research Council. By Donald M. Pillsbury, M.D., Marion B. Sulzberger, M.D., and Clarence S. Livingood, M.D. 8°, cloth, 421 pp., with 109 illustrations and 11 tables. Philadelphia and London: W. B. Saunders Company, 1942. $2.00.
Journal: New England Journal of Medicine (1943)
Editorial: An incident in Pyongyang
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An integrated clinical approach to predicting the benefit of tirofiban: Application of the TIMI risk score for unstable angina/non-ST elevation MI in PRISM-PLUS David A. Morrow, Elliott M. Antman, Carolyn H. McCabe, Eugene Braunwald, Pierre Theroux. Brigham &amp; Women's Hospital, Boston, MA, Montreal Heart Institute, Montreal, PQ, Canada
Journal: Journal of the American College of Cardiology (2001)
If active immunotherapy doesn't work..
Authors: P. Gunby
Journal: JAMA (1979)

The honey bee, at least according to one school of entomological thought, shares with the yellow jacket the distinction of being among the most common of the venomous stinging insects. Only the female honey bee stings, usually only on perceiving a threat. Mayo Clinic investigators from Rochester, Minn, reporting at the American Academy of Allergy meeting in New Orleans, described four patients sensitive to honey bee stings, for whom active immunization with honey bee venom failed to provide protection. All are from families that keep bees. Passive immunotherapy was attempted using plasma from hyperimmune beekeepers. Eventually, reported John W. Yunginger, MD, and P. J. Santrach, these patients could tolerate daily (deliberate) bee stings. However, systemic reactions again resulted if the interval between stings was increased to one week. Yunginger and Santrach conclude: "Clinical immunity to stings is not simply dependent on IgG phospholipase A antibody levels but may be modulated