tbuckley/cabot-search huggingface dataset:
Burning up
Authors: T. Dalrymple
Journal: BMJ (2012)

CD63 belongs to the transmembrane 4 superfamily of membrane proteins and is expressed in several normal tissues as well as in melanoma cells. Previous reports have suggested that CD63 may play an important role in inhibiting melanoma progression, and this was supported by our studies showing that CD63 was associated with suppression of the growth of melanoma in nude mice. Recently, we and others have shown that CD63 may form noncovalent associations with beta1 integrins, which suggests that the function of CD63 may be related to that of integrins. To further explore the role of CD63 in melanoma, we transfected CD63 into a highly motile, CD63-negative melanoma cell line, KM3, which was shown to express alpha(v)beta5 as the predominant integrin with only trace amounts of beta1 integrins. Following transfection, CD63 was shown to associate with beta1 integrins, and beta1 expression appeared to be up-regulated. Cell motility in serum-containing media was markedly suppressed following transfection of CD63. This inhibition was potentiated by mAbs to CD63, and correlated with the level of CD63 expression. The CD63-transfected, but not the untransfected, melanoma cells showed increased adhesion and migration on the beta1 substrates, fibronectin, laminin, and collagen, whereas rates of migration were similar on the beta5 substrate, vitronectin. These results show that CD63 is involved in regulation of the motility of melanoma cells and their adhesion and migration on substrates associated with beta1 integrins. We suggest they provide further insights into the role of CD63 in tumor progression.
Long Term Responses to Fludarabine and Rituximab in Waldenstrom’s Macroglobulinemia
Authors: Steven Treon, Andrew Branagan, Leukothea Ioakimidis, Jacob Soumerai, Christopher Patterson, Parveen Wasi, Christos Emmanouilides, Stanley R. Frankel, T. Andrew Lister, Pierre Morel, Jeffrey Matous, Stephanie A. Gregory, Eva K. Kimby
Journal: Blood (2008)
Renal
Authors: S. Picca, A. Bartuli, C. Dionisi-Vici, Strologo L. Dello, A. Villani, R. Bianchi, G. Salvatori, G. Rizzoni, G. O’Sabetta, P. Jouvet, F. Poggi, D. Rabier, J. M. Saudubray, N. Man, V. B. Nguyen, M. Jokic, C. Lecacheux, P. B. Baines, L. Smith, A. Petros
Journal: Intensive Care Medicine (1996)
Exogenous spermine induces maturation of the liver in suckling rats
Authors: I Wery
Journal: Hepatology (1996)

In the present study, we investigated the effects of spermine on postnatal liver maturation in suckling rats. The animals were given spermine either per os (8 micromol) or by intraperitoneal injection (1 micromol), once daily for three or five days. The percentage of liver cells in different cell cycle phases and of diploid cells in the parenchyma was estimated. The protein content, ornithine aminotransferase (OAT) activity, and content of DNA polyamines and receptors for polymeric immunoglobulins (RPI) were also measured in liver extracts. The ingestion of spermine had the following effects: the percentage of the cells in S and G2M phases of the cell cycle diminished the percentage of diploid cells increased the content of polymeric immunoglobulin receptors increased; the OAT activity increased; the contents of putrescine and spermidine decreased and almost reached adult values; and the spermidine/spermine ratio became similar to that observed in the liver of adult rats. These phenomena were detected 40 hours after the beginning of oral spermine treatment. The intraperitoneal injection of spermine had no effect on the OAT activity, but it decreased the spermidine content and enhanced the spermine content. Our data demonstrated for the first time that dietary polyamines play a role in the initiation of liver postnatal maturation in suckling rats. (Hepatology 1996 Nov;24(5):1206-10)
IS PNEUMONIA INCREASING?
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mammographic parenchymal patterns: more controversy
Authors: M. Moskowitz
Journal: JAMA (1982)

The article by Tabár and Dean (p 185) on mammographic parenchymal patterns for breast cancer, emanating as it does from a population-based trial with a high percentage of attendance, represents a very important piece of work. The early reports of Wolfe indicating a group of mammographically identifiable patients at extremely high risk for development of breast cancer was initially greeted with enthusiasm. However, several subsequent investigators were either unable to duplicate Wolfe's work completely or, at best, only partially reproduce it at lower levels.<sup>1-6</sup>It appears from several of the reported studies, including our own,<sup>6</sup>that of Egan and Mosteller,<sup>1</sup>and the current study in particular, that the risk of the P2/DY pattern seems to be associated mostly with the prevalence screen. In subsequent or in incidence years of screening, as is shown in the current article, the magnitude of the apparent risk drops either to insignificant
Book Review Medical Parasitology and Zoology . By Ralph W. Nauss, M.D., Dr.P.H. With a foreword by John C. Torrey, Ph.D. 8°, cloth, 534 pp., with 95 illustrations and 15 tables. New York: Paul B. Hoeber, Incorporated. 1944. $6.00.
Journal: New England Journal of Medicine (1944)
Predicting in-hospital mortality in acute type a aortic dissection: Lessons from the international registry of aortic dissection (IRAD) Rajendra H. Mehta, Peter G. Hagan, Toru Suzuki, Eduardo Bossone, Dan Gilon, Alfredo Llovet, Jeanna Cooper, Linda Pape, William F. Armstrong, David Bruckman, Christoph A. Nienaber, Kim A. Eagle. University of Michigan Center for IRAD Investigators, Ann Arbor, MI, University Eppendorf, Hamburg, Germany
Journal: Journal of the American College of Cardiology (2001)
Prevalence of Dissociative Disorders in Psychiatric Outpatients
Authors: Brad Foote, Yvette Smolin, Margaret Kaplan, Michael E Legatt, Deborah Lipschitz
Journal: American Journal of Psychiatry (2006)

Objective: The purpose of the study was to assess the prevalence of DSM-IV dissociative disorders in an inner-city outpatient psychiatric population. Method: Subjects were 231 consecutive admissions (84 men and 147 women, mean age=37 years) to an inner-city, hospital-based outpatient psychiatric clinic. The subjects completed self-report measures of dissociation (Dissociative Experiences Scale) and trauma history (Traumatic Experiences Questionnaire). Eighty-two patients (35%) completed a structured interview for dissociative disorders (Dissociative Disorders Interview Schedule). Results: The 82 patients who were interviewed did not differ significantly on any demographic measure or on the self-report measures of trauma and dissociation from the 149 patients who were not interviewed. Twenty-four (29%) of the 82 interviewed patients received a diagnosis of a dissociative disorder. Dissociative identity disorder was diagnosed in five (6%) patients. Compared to the patients without a dissociative disorder diagnosis, patients with a dissociative disorder were significantly more likely to report childhood physical abuse (71% versus 27%) and childhood sexual abuse (74% versus 29%), but the two groups did not differ significantly on any demographic measure, including gender. Chart review revealed that only four (5%) patients in whom a dissociative disorder was identified during the study had previously received a dissociative disorder diagnosis. Conclusions: Dissociative disorders were highly prevalent in this clinical population and typically had not been previously diagnosed clinically. The high prevalence of dissociative disorders found in this study may be related to methodological factors (all patients were offered an interview rather than only those who had scored high on a screening self-report measure) and epidemiological factors (extremely high prevalence rates for childhood physical and sexual abuse were present in the overall study population).
Postaortotomy myoctic pseudoaneurysm. A nonvalvular, potentially resectable source of intravascular sepsis following prosthetic valve surgery
Authors: O. B. Garfein
Journal: JAMA (1973)

Septicemia following prosthetic valve surgery often is assumed to represent infection involving the prosthesis. The source of persistent septicemia in a patient who had aortic valve replacement was not the valve, but the aortic suture line. While reoperation on an infected valve prosthesis is almost certain to result in failure, reoperation on extravalvular sources of sepsis may be successful.
Decision making in anesthesiology. Experiences with a new automated technique for interview
Authors: P. Chodoff
Journal: JAMA (1971)

Thirty adult preanesthetic interviews were performed, ten with a cathoderay-type input device and 25 with a mark-sense form. An International Business Machines Corporation system 360 model 40 computer with disk files was used. Three representative decisions were calculated: recent upper respiratory tract infection (URI), chronic smoker, and clues to chronic obstructive lung disease. The system should (1) upgrade the level at which allied professional personnel can function, (2) enlarge the role of the outpatient clinic, (3) reduce the length of hospital stay, (4) improve the quality of medical care, (5) reduce hospital costs, (6) improve the utilization of hospital beds and operating rooms, and (7) provide a tool for epidemiologic investigation of problems relating to anesthesiology.
Photosensitivity Guide Errors
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Suggestion.
Authors: James W. Hervey
Journal: JAMA (1894)

Indianapolis, Ind., Feb. 15, 1894. <h3>To the Editor:</h3> —Permit your correspondent to express the opinion that ourJournalmight be more useful, more generally read and kept closer in touch with the general profession by having a department for " Gleanings From the Reports of Medical Societies." To utilize this suggestion each society should elect or appoint a competent reporter or corresponding secretary, whose duty it should be to give a brief report of each paper read and case reported that the society deemed of sufficient importance to interest the general profession. These short reports should be sent to theJournalfor the consideration of its editors who would doubtless be glad to give them to their readers, or such parts of them as they might think proper. This plan would identify every society with theJournal, and make the members of the different societies anxious to read what might be
Tuberculosis: when not to order roentgenograms
Authors: G. M. Lordi
Journal: JAMA (1985)

IN 1979, the National Center for Devices and Radiological Health of the Food and Drug Administration sponsored the formation of a Chest X-ray Panel to review the selection of patients for chest x-ray screening examinations. The panel's recommendations have recently been published.<sup>1</sup>The panel's statements regarding pulmonary tuberculosis are of particular interest and should be emphasized. Essentially, the panel concluded that (1) the yield of tuberculosis cases found by screening or repeated chest x-ray examinations was not sufficient to justify the monetary cost or added radiation exposure, (2) mandated chest x-ray examinations as a condition of initial or continued employment were not productive for tuberculosis detection, (3) repeated chest x-ray examinations of persons with significant tuberculin reactions (without current disease), including those not treated with isoniazid, were not of value, (4) repeated chest x-ray examinations of asymptomatic patients with tuberculosis who had completed treatment were of insufficient clinical value,
Trauma Registries
Authors: Daniel A. Pollock
Journal: JAMA (1989)

Hospital trauma registries are evolving rapidly as a result of a renewed focus on trauma care evaluation and recent advances in microcomputer technology. In theory, trauma registries can serve as the principal tool for the systematic audit of the quality of patient care provided by a hospital or a trauma system and as a potential source of part of the data needed for injury surveillance. In practice, however, there is a tendency to underestimate the resources needed to initiate and maintain a registry. Herein, we describe the purposes, resource requirements, and limitations of trauma registries. We conclude that standardization of case criteria, core data content, data definitions, and coding conventions can enhance the utility of trauma registries. (<i>JAMA</i>. 1989;262:2280-2283)
This Week in &lt;EMPH TYPE="ITAL"&gt;JAMA&lt;/EMPH&gt;
Journal: JAMA (2004)

A Piece of My Mind"Only from a place of such hopelessness and suffering can I fully cherish the sunlight, hear the music of the wind, and know the sacredness of birds singing at sunrise."From "Normal Is a Place I Visit." SEE PAGE 2924 Medical News & PerspectivesA clinical trial is under way to determine whether using gene chips to generate gene-expression profiles of tumors can help guide therapy for patients with breast cancer.
Mixed News on Hospital Infections
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract A40: Expression of cancer-associated fibroblast-related proteins differs between invasive lobular carcinoma and invasive ductal carcinoma
Authors: Kim Eun-Sol, Koo Ja Seung
Journal: Cancer Research (2017)

Abstract Purpose: Cancer-associated fibroblasts (CAFs) are classified into various functional subtypes such as fibroblast activation protein-α (FAP-α), fibroblast specific protein-1 (FSP-1), platelet-derived growth factor receptor-α (PDGFR-α), and PDGFR-β. In this study, we compared the expression of CAF-related proteins in invasive lobular carcinoma (ILC) with those in invasive carcinoma of no special type (NST), and assessed the implications of the differences observed. Methods: Using tissue microarrays of 104 ILC and 524 invasive carcinoma (NST) cases, immunohistochemistry for CAF-related proteins [podoplanin, prolyl 4-hydroxylase, FAP-α, FSP-1/S100A4, PDGFR-α, PDGFR-β, and chondroitin sulfate proteoglycan (NG2)] was conducted. Results: In invasive carcinoma (NST), tumor cells expressed a high level of PDGFR-α, whereas ILC tumor cells expressed high levels of podoplanin, prolyl 4-hydroxylase, FAP-α, and FSP-1/S100A4. In stromal cells of invasive carcinoma (NST), high expression levels of prolyl 4-hydroxylase, PDGFR-α, and NG2 were observed, whereas ILC stromal cells expressed high levels of FAP-α, FSP-1/S100A4, and PDGFR-β. In ILC, tumoral FSP-1/S100A4 positivity was associated with higher Ki-67 labeling index (p = 0.010) and non-luminal A type cancer (p = 0.014). Stromal PDGFR-α positivity was associated with lymph node metastasis (p = 0.011). On survival analysis of entire cases, tumoral FSP-1/S100A4 positivity (p = 0.001) and stromal podoplanin positivity (p = 0.035) were associated with shorter disease-free survival; only tumoral FSP-1/S100A4 positivity (p = 0.001) was associated with shorter overall survival. Conclusion: In ILC, the expression of FAP-α and FSP-1/S100A4 was higher in both tumor and stromal cells than that observed in invasive carcinoma (NST). These results indicate that CAFs are a potential target in ILC treatment. Citation Format: Lee YuKyung, Kim Eun-Sol, Koo Ja Seung. Expression of cancer-associated fibroblast-related proteins differs between invasive lobular carcinoma and invasive ductal carcinoma. [abstract]. In: Proceedings of the AACR Special Conference on Translational Control of Cancer: A New Frontier in Cancer Biology and Therapy; 2016 Oct 27-30; San Francisco, CA. Philadelphia (PA): AACR; Cancer Res 2017;77(6 Suppl):Abstract nr A40.
PHENOMENA OF ALLERGY IN DISEASES OF THE SKIN
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MISCELLANY.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Talc and Condoms-Reply
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal