tbuckley/cabot-search huggingface dataset:
Improved hepatocyte in vitro maintenance in a culture model with woven multicompartment capillary systems: Electron microscopy studies
Authors: J GERLACH
Journal: Hepatology (1995)

Primary pig hepatocytes form a tissuelike structure in an in vitro culture model that has provision for three-dimensional cell orientation, cell aggregation, decentralized cell perfusion with low metabolite gradients, integral oxygenation, and nonparenchymal cell coculture. Scanning electron microscopy (SEM) has shown that hepatocytes spontaneously form aggregates in a three-dimensional structure between and on the surface of artificial capillaries. Transmission electron microscopy (TEM) has shown that after 7 weeks of in vitro perfusion, the cell ultrastructure remains similar to that of the parenchyma in vivo. Golgi complexes, active membrane processes, reorganization of cell junctions, and bile canaliculi-like intercellular spaces were demonstrated.
Physician referral--the AMA view
Authors: J S Todd, J K Horan
Journal: JAMA (1989)

Todd and Horan present the American Medical Association's view of the problem of physician referral of patients to health facilites in which the physician has a financial interest. Studies of physician referral by the federal government and the AMA raise additional questions about the relationship between physician ownership and utilization of services. The AMA argues against banning legitimate investments, an action that it believes would adversely affect access to care, the introduction of new technology, and efforts to improve care and reduce costs. It proposes the development of clear guidelines on physician ownership and referral practices that should include: (a) standards for investment options, (b) establishment of a process to help physicians determine the legality of proposed investment in advance, and (c) establishment of a phase-in period for federal regulations and/or legislation and required divestiture.
Toxicogenomics Through the Eyes of Informatics: Conference Overview and Recommendations
Authors: Kenneth Olden, Neysa Call, Bruno Sobral, Robin Oakes
Journal: Environmental Health Perspectives (2004)

The availability of genome-scale DNA sequence information has radically altered life science research.Moreover, the human genome project has revolutionized the practice of biology and the potential of medicine.The field of toxicology will be greatly augmented by the application of the knowledge of genetics and its sister sciences.Consequently, researchers have entered a new area of specialty-toxicogenomics-the marriage of toxicology and genomics.Data generated by such research will impact many areas including health and environmental sciences.In addition, the science and health care communities will also be better able to identify a wide range of human health risks.However, to realize the potential of toxicogenomics, a global view of gene function and temporal and spatial regulations for all genes at different physiological or pathological states or developmental stages is paramount.The expanding field of bioinformatics offers the convergence of biological, mathematical, and computational platforms to better understand the effects of toxins on biological systems.Scientists using data developed by the modern advent of biotechnology need novel and efficient bioinformatics tools to monitor gene-environment interactions on a large scale.These bioinformatics platforms (hardware, software, portals, and models, for example) will allow the conversion of data into useful knowledge to prevent disease resulting from environmental exposures.
Random allocation III
Authors: P. Sedgwick
Journal: BMJ (2009)

A randomised controlled trial investigated the effectiveness of immobilisation after intrauterine insemination.1 Couples were recruited if the woman needed intrauterine insemination for unexplained subfertility or for subfertility related to cervical factors or male subfertility. A total of 391 couples were recruited from seven teaching hospitals in Holland. Couples were then categorised according to the age of the woman (18-34 or 35-43 years). For each age category at each hospital, couples were randomly allocated either to 15 minutes of immobilisation or immediate mobilisation (control intervention) after intrauterine insemination. Which of the following statements, if any, are true?
Multiple severe complications from recreational ingestion of MDMA ('Ecstasy')
Authors: C. Brown
Journal: JAMA (1987)

<h3>To the Editor.—</h3> We would like to report the case of a young woman who suffered serious but reversible toxic reactions from a recreational dose of 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") and whose blood levels of MDMA were much higher than in any of the fatalities reported by Dowling et al.<sup>1</sup> <h3>Report of a Case.—</h3> A 32-year-old woman and her friend, both of whom had used MDMA before, ingested an alleged 100 to 150 mg of MDMA powder mixed in apple juice. The patient reported rapid onset of general body tingling, vivid color enhancement, and visual hallucinations, but had no memory of ensuing events. Two hours after ingestion, her friend brought her to the emergency department. Significant findings included agitation; hallucinations; combativeness; diaphoresis; dilated pupils (7 mm); pulse rate, 150 beats per minute; blood pressure, 90/50 mm Hg; respirations, 36/min; rectal temperature, 41.6°C; diffuse wheezing; diminished bowel sounds; vertical nystagmus; tonic
The Miser in the Great Russian Novel, "Dead Souls," as a Study of Senile Dementia.
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
POISONING BY EXALGINE.
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE NERVOUS CONTROL OF INSULIN SECRETION
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE SECRETIN THEORY OF PANCREATIC SECRETION
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Milroy Lectures ON KALA-AZAR, Delivered before the Royal College of Physicians of London
Authors: L. Rogers
Journal: BMJ (1907)

stain deeply and are easy to count.The total result is very effective.Adult Para8ites.-Whensegments are stained in this way the internal structures particularly the reproductive organs and the ova, are well brought out.It is best to allow the parasites or the segments to remain in the acid solution for about one hour, and in the eosin solution over a night.After thorough drying with absorbent paper they are cleared in clove oil or xylol for twenty-four hours and then mounted in balsam.Spores.-My colleague, Dr. J. A. Nixon, working with certain fungi of the skin and hair, informs me that he finds this device gives very satisfactory results with those spores which are only stained with difficulty by the methods usually employed for this purpose.
Dr. Leo M. Michalek, Jr., Is Not Dead.
Journal: JAMA (1975)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cytogenetics
Authors: J. F. Loutit
Journal: BMJ (1967)

Drug self-administration models of addiction typically require animals to make the same response (e.g., a lever-press or nose-poke) over and over to procure and take drugs. By their design, such procedures often produce behavior controlled by stimulus–response (S-R) habits. This has supported the notion of addiction as a “drug habit,” and has led to considerable advances in our understanding of the neurobiological basis of such behavior. However, to procure such drugs as cocaine, addicts often require considerable ingenuity and flexibility in seeking behavior, which, by definition, precludes the development of habits. To better model drug-seeking behavior in addicts, we first developed a novel cocaine self-administration procedure [puzzle self-administration procedure (PSAP)] that required rats to solve a new puzzle every day to gain access to cocaine, which they then self-administered on an intermittent access (IntA) schedule. Such daily problem-solving precluded the development of S-R seeking habits. We then asked whether prolonged PSAP/IntA experience would nevertheless produce “symptoms of addiction.” It did, including escalation of intake, sensitized motivation for drug, continued drug use in the face of adverse consequences, and very robust cue-induced reinstatement of drug seeking, especially in a subset of “addiction-prone” rats. Furthermore, drug-seeking behavior continued to require dopamine neurotransmission in the core of the nucleus accumbens (but not the dorsolateral striatum). We conclude that the development of S-R seeking habits is not necessary for the development of cocaine addiction-like behavior in rats. <b>SIGNIFICANCE STATEMENT</b> Substance-use disorders are often characterized as “habitual” behaviors aimed at obtaining and administering drugs. Although the actions involved in consuming drugs may involve a rigid repertoire of habitual behaviors, evidence suggests that addicts must be very creative and flexible when trying to procure drugs, and thus drug seeking cannot be governed by habit alone. We modeled flexible drug-seeking behavior in rats by requiring animals to solve daily puzzles to gain access to cocaine. We find that habitual drug-seeking isn9t necessary for the development of addiction-like behavior, and that our procedure doesn9t result in transfer of dopaminergic control from the ventral to dorsal striatum. This approach may prove useful in studying changes in neuropsychological function that promote the transition to addiction.
A Role for Aspirin in Cancer Prevention?
Journal: Cancer Discovery (2013)

Abstract Although the organizations that issue guidelines for clinical care do not recommend taking aspirin for cancer prevention, there is mounting evidence that the drug reduces the risk of colorectal and other cancers, especially in high-risk patients. The creation of databases tracking patient outcomes, as well as a better understanding of how aspirin exerts its cancer-fighting effects, could help physicians determine the best candidates for a daily regimen of low-dose aspirin to prevent disease.
The Blood.
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Autopsy
Authors: Alfred Angrist
Journal: JAMA (1973)

<h3>To the Editor.—</h3> With the renewed stress now being given to the patient and to medical practice, its clinical teaching and to continuing education, to peer review and the Professional Standards Review Organization, and evaluation and judgment of adequacy of care, it would seem that there would be a new interest in the telltale final analytical autopsy. The appeal of John Prutting, MD, is not for an arbitrary minimal low or high percentage of autopsies done in a perfunctory, "halfhearted manner for percentage sake." The quality of the performance of each autopsy is as critical as the total number done or the percentage of deaths examined. The point is that the Accreditation Commission can evaluate this aspect of performance by the examination of autopsy records, their use in mortality and other conferences, and in Clinical Pathological Conferences. This can be determined more easily than many other less tangible aspects of
Glint of Gold Tooth in a Poorly Lit Kitchen
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 1338: The Role of the Estrogen Receptor 46 Hydrophobic Domain on Endothelial Membrane-initiated Signaling
Authors: Kyung Hee Kim, Lei Li, Koji Hisamoto, David Stepensky, Peter Cresswell, Jeffrey R Bender
Journal: Circulation (2007)

The expression of Estrogen Receptor 46 (ER46, 174 –595 aa), an N-terminus truncated isoform of the Estrogen Receptor α, in human endothelial cells (EC), and its critical role in membrane-initiated, rapid responses to 17β-estradiol (E2) have been reported. ER46 is targeted to human EC caveolar membranes, where it is a component of a complex containing c-Src, PI3-Kinase (PI3K), Akt and eNOS. E2 rapidly activates eNOS via c-Src/PI3K/Akt in EC. A highly conserved hydrophobic region of ER46, adjacent to a critical palmitoylation site (Cys447), may be required for its membrane localization and function. We generated a hydrophobic region mutant, “4Gly” (I451G/I452G/L453G/L454G), to evaluate the importance of this domain on ER46 membrane localization, eNOS activation, ER46 dimerization, and protein-protein (ER46-c-Src) interactions. Peripheral plasma membrane staining with cell impermeant E2-horse radish peroxidase (E2-HRP) was observed in COS-7 cells transiently transfected with ER46, but not with 4Gly. E2-BSA (30 nM, 10 min) induced eNOS phosphorylation (Ser1177) in plasma membrane fractions of ER46- but not 4Gly- transfected COS-7 cells. Using Fluorescence Resonance Energy Transfer (FRET), we demonstrated that ER46 and the 4Gly mutant both undergo homodimerization, although 4Gly less efficiently. The protein-protein interaction between ER46 and c-Src was also assessed by FRET. The FRET efficiency between mCerulean-tagged ER46 and EYFP-tagged c-Src was significantly increased after E2-BSA (40 nM, 10 min) stimulation in transiently transfected HeLa cells, indicating an E2-induced ER46-c-Src interaction within 75 Å. The FRET efficiency of c-Src-4Gly was 50% compared to that seen with the wild type ER46 in these reconstitution experiments. These results demonstrate that this conserved hydrophobic region of ER46 is critical for the subcellular localization, for required protein-protein interactions and for consequent membrane-initiated rapid signaling responses to E2.
THE PRESENT STATUS OF CONVALESCENT SERUM THERAPY
Journal: JAMA (1929)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Oligometastases.
Authors: S Hellman, R R Weichselbaum
Journal: Journal of Clinical Oncology (1995)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1995.13.1.8 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 7799047 Oligometastases. S HellmanxS HellmanSearch for articles by this author , R R WeichselbaumxR R WeichselbaumSearch for articles by this author https://doi.org/10.1200/JCO.1995.13.1.8 First Page PDF © 1995 by American Society of Clinical Oncology
Postgraduate Courses in Radiology
Journal: JNCI Journal of the National Cancer Institute (1987)

Journal Article Postgraduate Courses in Radiology Get access JNCI: Journal of the National Cancer Institute, Volume 78, Issue 6, June 1987, Page 1253, https://doi.org/10.1093/jnci/78.6.1253-d Published: 01 June 1987