tbuckley/cabot-search huggingface dataset:
THE 24-HOUR THALLIUM IMAGES IN DUAL ISOTOPE MYOCARDIAL PERFUSION SCINTIGRAPHY: CLINICAL UTILITY AND PROGNOSTIC SIGNIFICANCE
Authors: M. S. Kipper, J. J. LaBarbera, L. D. Krohn
Journal: Clinical Nuclear Medicine (1998)

s Presented At The 22Nd Annual Western Regional Meeting Of The Society Of Nuclear Medicine October 1997
Progress in Neurology and Psychiatry: An Annual Review, Volume VIII
Journal: JAMA (1953)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Operative Surgery.
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Radical Pancreatoduodenectomy with Resection and Transplantation of the Portal Vein
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Management of breast cancer: radical mastectomy
Authors: T. J. Anglem
Journal: JAMA (1974)

ONE of the oddities occasionally encountered in science or medicine is the emergence, and for a time the spread, of an idea in spite of a great preponderance of evidence to the contrary. Usually when this occurs it can be accounted for by the prestige or reputation of one or more of its sponsors and the inherent desirability of the goal toward which the idea is directed, quite apart from its practicability. A classic example of this phenomenon in recent history was the socalled Lysenko Affair<sup>1-3</sup>in which the Russian antimendelian agronomistbiologist T. D. Lysenko claimed to have discovered a method of preconditioning wheat grain whereby it could be planted in the summer and harvested in the winter, and planted in the winter and harvested in the summer. He declared that all plant and human life could be controlled by environment. Jovarsky<sup>1</sup>says, Between 1933 and 1935 he
Brentuximab Vedotin
Authors: Changchun Deng, Beiqing Pan, Owen A. O'Connor
Journal: Clinical Cancer Research (2012)

Brentuximab vedotin (SGN-35), an intravenously administered CD30-specific antibody-drug conjugate, has recently been approved by the U.S. Food and Drug Administration for two indications, including (i) patients with Hodgkin lymphoma relapsing after autologous stem-cell transplantation (ASCT), or after two multidrug regimens in patients with Hodgkin lymphoma who are not candidates for ASCT; and (ii) patients with systemic anaplastic large cell lymphoma (ALCL) who failed at least one prior multidrug chemotherapy regimen. Patients with Hodgkin lymphoma and ALCL treated with brentuximab vedotin showed markedly high response rates for a single agent, exceeding 70% and 80% for Hodgkin lymphoma and ALCL, respectively. The complete response rate was equally as impressive, at 34% and 57% for Hodgkin lymphoma and ALCL, respectively. Results like these and from many other upcoming clinical trials, in which brentuximab vedotin is being investigated in the frontline setting, promise to profoundly change how we manage the CD30-positive lymphoproliferative malignancies. The mechanism of action, preclinical antitumor activity, and clinical activity of brentuximab vedotin against Hodgkin lymphoma, ALCL, and other CD30-expressing lymphomas are reviewed.
Health Services Utilization in Jerusalem Under Terrorism
Authors: Itzhak Levav
Journal: American Journal of Psychiatry (2006)

Objective: The authors explored the effects of an escalation of terrorism on the help-seeking behavior of the general population in Jerusalem, a city that offers an adequate supply of medical and psychiatric services. Method: Time-series analyses were applied to examine the utilization of health services (primary medical care and ambulance calls) and mental health services (clinics, hospitals, and telephone hotlines) by Jerusalem residents before and during part of the current intifada. The authors assessed seasonality, general linear trends (from factors such as health education and increased access), short-term intifada impact (reflecting reactions that peaked at the third month and ended 1 year thereafter), and long-term impact (starting at the intifada outbreak and reflecting a more stable population behavior). Results: Adult psychiatric outpatient visits did not change except for the elderly in ongoing care who had both short- and long-term increases. The proportion of recorded ICD-10 diagnoses reflecting intifada-related reactions remained generally stable. Short-term effects included an increase in psychiatric readmissions. First contacts to substance abuse clinics remained unchanged. While long-term effects included a decrease in new psychiatric hospitalizations, the rate of monthly general practitioner visitors and the number of monthly ambulance and hotline calls increased. Conclusions: Except for the elderly and previously hospitalized persons, Jerusalem residents did not increase their use of psychiatric services but did increase their use of some other health services. These results suggest that this terrorism-affected population did not perceive their mental and social suffering as requiring specialized intervention.
Oxygen Masks
Authors: A. L. Barach
Journal: BMJ (1956)

<h3>Background</h3> STIs are a major public health concern. Screening programmes for asymptomatic users are key components of STI control. Traditional limitations of screening programmes include low population coverage and delays in treatments, thus reducing the expected impact on STI control. In our centre, the normal time from test to results was 4 days, and 7 days until treatment was established. To reduce time to treatment and to increase population coverage, we developed ‘Drassanes Exprés’, a testing service for asymptomatic STIs. The objectives of this study were to provide a guide for the implementation of a service with these characteristics and to evaluate the results of this intervention. <h3>Methods</h3> The Drassanes Exprés programme was launched in Spain on 07 November 2016 as a public, confidential and free-of-charge testing service for asymptomatic STIs, with same-day result notification. For this walk-in service, confidentiality was obtained by registering all information into the Laboratory Internal Software instead of the Electronic Patient Records. Samples were processed in a point-of-care laboratory and result notification was provided via mail or short message service. Information about workflow, screening protocols and result interpretation is detailed. Additionally, demographic characteristics, STI prevalence, and time from patients’ sample collection to notification and treatment are analysed. <h3>Results</h3> Between 07 November 2016 and 07 November 2019, 13 993 users attended the Drassanes Exprés screening programme. Of these, 0.5% were transgender people, 29.3% women, 45.2% men who have sex with men and 25.1% men who have sex with women. The median age was 31 years (range: 26–39 years). Overall, 14.6% of users tested positive for at least one STI. The most prevalent infection was <i>Chlamydia trachomatis</i> (8.3%), followed by <i>Neisseria gonorrhoeae</i> (5.7%), syphilis (1.8%), HIV (0.4%) and hepatitis C virus (0.2%). The median time from test to results was 2.4 hours (range: 2–3.1 hours). Of 2049 users diagnosed with an STI, treatment was achieved in 97.0% of cases; the average time to treatment was 2.0 days. <h3>Conclusions</h3> Drassanes Exprés is the first public programme for rapid, asymptomatic, STI screening and treatment in Spain. Assessing high-risk practices and providing confidentiality, easy access and rapid results/treatments are key elements in the development of STI screening programmes.
COLLECTIVE INVESTIGATION OF THE ANTITOXIN TREATMENT OF DIPHTHERIA.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Textbook Erratum
Authors: Paul B. Beeson
Journal: JAMA (1975)

<h3>To the Editor.—</h3> We request use of your column to warn of a dangerous drug dosage error in the article on "Infective Endocarditis" by one of us (P.B.B.) in the new (14th) edition of the<i>Textbook of Medicine</i>, published by W.B. Saunders Company. The error is on page 315 in column 1, paragraph 6, where the recommended dose of gentamicin is given as 50 to 100 mg/kg of body weight.<i>The correct figure should be "1.0 to 1.5 mg/kg of body weight, intramuscularly or intravenously, every eight hours."</i>We would also like to amend the drug dosage of<i>kanamycin</i>that appears in the same paragraph, from 10 to 20 mg/kg of body weight to read: "<i>5 mg</i>/kg of body weight, intramuscularly or intravenously, every eight hours." The error was discovered after several thousand copies of the book had been distributed in May and June of this year. All copies
Selected New Books
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Gastroduodenal Physiology
Authors: Ma Kaps1, R Hatz1, E Bayerdorffer3, M Stoite4, H.-J Krimling1, G Enders2, Dpt Of, Gastrltis Associated, R Rieder, G Hatz
Journal: Gut (1995)

Aim: Helicobacter pylori (H.p.)-infected individuals develop high IgG-antibody titers against H.p. in serum.IgA and lgG against H.p. have also been detected in gastric juice.The aim of the study was to define whether these specifically against H.p. antigen directed immunoglobulins are locally produced by plasma cells within the gastric mucosa.Methods: An enzyme-linked immunospot assay (ELISPOT) was developed, coded with water soluble proteins (WSP) from the H.p. reference strain NCTC 11637.Lymphocytes were separated by percoll gradient from single cell suspensions obtained from gastric biopsies of patients with gastritis, ulcer and of non-infected persons.H.p.-status was defined by serological (ELISA) and histopathological findings (Warthin-Starry-staining). The Sydney-system was used to classify chronicity and activity of gastritis.Results: Immunoglobulin-producing cells were found in 63 % of H.p.-positive patients.All of them showed IgA-class immunospots and in 60 % in addition IgG-class immunospots.The detection of immunospots correlated significantly with the diagnosis gastritis or ulcer and with the extent of activity and chronicity.In some cases showing no gastritis or ulcer but high serum 1gG-titers immunospots against H.p. were found.All H.p.- negative individuals were negativ in the ELISPOT.Conclusions: H.p. induces an antigen-specific local humoral immune response which correlates well with the grade of inflammation and the degree of H.p.-cobonization.The specifity of the ELISPOT assay is high.It may be used as a method to detect antigen-specific local immunoglobulin production against selected H.p.-antigens.
PWE-140 Persistent symptoms following cholecystectomy is unacceptably high and in need of further evaluation
Authors: R Radwan, C Brown, A Rasheed
Journal: Gut (2012)

<h3>Introduction</h3> Up to 20% of patients undergoing cholecystectomy continue to experience symptoms. We consider such results unacceptably high and in need of further evaluation. Our aim was to identify the biliary symptoms for which cholecystectomy was carried out and then determine the prevalence and the nature of persistent symptoms following the procedure in a cohort of 500 consecutive cases. <h3>Methods</h3> A validated pre-operative symptoms survey was completed at the time of listing of 500 consecutive laparoscopic cholecystectomies (LC), followed by a follow-up phone survey 12 weeks after the procedure to record the nature, severity and frequency of symptoms experienced pre- and post-operatively. A detailed clinical profiling was carried out on all patients with persistent biliary symptoms. <h3>Results</h3> All patients had at least two symptoms pre-operatively and 337 (67.4%) had three or more. The most common symptoms pre-operatively were abdominal pain (93.8%), nausea (65.8%), pain related to food (54.4%) and bloating (48.6%). A total of 90 patients were symptomatic postoperatively. 81 patients (16.2%) complained of abdominal pain, while 63 (12.6%) patients also experienced associated dyspeptic symptoms. Seventy three patients (14.6%) developed one or more new symptoms post-operatively, the most common being heartburn found in 34 (6.8%) and abdominal bloating in 29 (5.8%). 60 patients underwent further investigation following LC; 36 patients went on to have a secondary diagnosis made, the most common (13/36) being hiatus hernia, seven patients were found to have a retained common bile duct stone. Overall, there was no significant difference in histology among patients post-operatively. <h3>Conclusion</h3> A significant number of patients continue to experience symptoms following laparoscopic cholecystectomy. In patients where pain was the most troublesome symptom preoperatively, significant symptomatic improvement was noted. Similarly, those patients that experienced symptoms more dyspeptic in nature preoperatively were less likely to be symptom free following LC. A careful biliary history, a focused physical examination and a thorough pre-operative assessment must be carried out prior to LC to rule out conditions that masquerade as gallbladder disease. <h3>Competing interests</h3> None declared.
Reply
Authors: Shao‐Lai Zhou, Jian Zhou
Journal: Hepatology (2016)

Potential conflict of interest: Nothing to report. Author names in bold designate shared co‐first authorship. We read with great interest the Zou et al. correspondence and appreciate the important comments on our findings. In this study,1 we used a xenograft model for our investigation on the interactions between hepatocellular carcinoma (HCC) cells and tumor‐associated macrophages (TAMs). This model was established at our institute by Dr. Tang and provides a platform for research on HCC metastasis.2 Although BALB/c nude mice are immunodeficient and lack T cells, other immune cells, such as macrophages and neutrophils, are normal and functional. In the tumor microenvironment, a variety of nonmalignant stromal cells may interact with one another in many ways, which cannot all be investigated in one study. In our study, we emphasized cross‐talk between HCC cells and TAMs. However, the interactions between TAMs and T cells were not within the scope of the study. Furthermore, we confirmed the direct effect of human interleukin‐34 (IL‐34) on the proliferation and chemotactic migration of human macrophages through its receptor, CSF1R. Although the amino acid sequence of human IL‐34 shares only 68.2% homology with mouse IL‐34, animal studies revealed similar results as our in vitro experiments.1 We proposed that the IL‐34 secreted by human HCC cells can be recognized by mouse CSF1R on the cell surface of macrophages, to promote their proliferation and migration. Zou et al. also stated that colony‐stimulating factor 1 (CSF1) should be considered when studying the miR‐28‐5p‐IL‐34‐macrophage feedback loop in HCC cells. In our identification of target genes, alterations of miR‐28‐5p had no effect on expression of CSF1 by HCC cells, so we proposed that although the CSF1/macrophage axis may exist in the HCC microenvironment, the miR‐28‐5p‐IL‐34‐macrophage feedback loop in HCC cells is independent of CSF1. Macrophages in different tumor microenvironments have distinct roles,4 but they have the general characteristic of tumor promotion in HCC cells,5 which we confirmed in our study. The specific role played by TAMs in the HCC microenvironment will be a focus of our future studies.
Overwork
Authors: John M. Rhoads
Journal: JAMA (1977)

Overwork, ie, working beyond one's endurance and recuperative capacities, may be a hazard in certain personality types engaged in open-ended occupations. Some persons appear to lack an inner "governor" and for various reasons ignore the commonplace signs that inform one of the need for rest or recreation. If they are engaged in occupations that do not have a finite workday, they may at times exceed their bodies' ability to recover. Clusters of symptoms may then develop, some of which may mimic serious physical ailments. Treatment depends on diagnosing the extent of illness and eliciting the underlying causes. Correction involves enforced rest, therapy that may vary from counseling to hospitalization and specialized treatment, but that must include the reeducation of the person to be aware of and make provision for his physical and emotional needs. (<i>JAMA</i>237:2615-2618, 1977)
Subcellular distribution of glucocorticoid receptor in cultured rat and human liver-derived cells and cell lines: Influence of dexamethasone
Authors: D Raddatz, M Henneken, T Armbrust, G Ramadori
Journal: Hepatology (1996)

Glucocorticoid receptor (GR) distribution in isolated rat hepatocytes and nonparenchymal hepatic stellate cells, Kupffer cells, and liver fibroblasts with and without dexamethasone treatment was investigated by immunostaining and confocal laser scanning microscopy. In addition, human liver fibroblasts, Hep3B and HepG2 cells were investigated. Subcellular distribution of GR immunostaining was assessed semiquantitatively by digital image analysis. Short–term incubation of rat liver cells with dexamethasone resulted in an increase of nuclear staining. The same was true for human liver fibroblasts. In contrast, predominant nuclear staining could be observed in untreated as well as in dexamethasone–treated Hep3B and HepG2 cells. By means of reverse–transcription polymerase chain reaction, it could be shown that messenger RNA of both known human GR isoforms, hGR α and nonhormone–binding hGR β, are present in human cells. Furthermore, dexamethasone binding indicates that hGR α protein is expressed in all human cells investigated. The data of this study show that GR is present in all cells investigated. Rat liver cells and human liver fibroblasts contain a translocating GR, suggesting that glucocorticoid action is receptor mediated in these cells. Nuclear localization of unliganded GR in Hep3B and HepG2 indicates that factors other than glucocorticoids may direct subcellular GR distribution.