tbuckley/cabot-search huggingface dataset:
The Combination of Quizartinib with Azacitidine or Low Dose Cytarabine Is Highly Active in Patients (Pts) with FLT3-ITD Mutated Myeloid Leukemias: Interim Report of a Phase I/II Trial
Authors: Waleed Abdelall, Hagop M. Kantarjian, Gautam Borthakur, Guillermo Garcia-Manero, Keyur P. Patel, Elias J. Jabbour, Naval G. Daver, Tapan Kadia, Rosilyn A. Gborogen, Marina Konopleva, Farhad Ravandi, Michael Andreef, Jorge E. Cortes
Journal: Blood (2016)
Attaining Manhood: A Doctor Talks to Boys About Sex
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Another First
Authors: Stephen M. Seltzer
Journal: JAMA (1972)

<h3>To the Editor.—</h3> I became excited when I opened the Oct 2,1972 issue ofThe Journaland saw an article entitled "Embolization of a Solitary Kidney." I immediately wondered where the kidney had embolized. To my dismay, however, I noticed that the article was really about "Embolization to a Solitary Kidney." If you can really get an article entitled "Embolization of a Solitary Kidney" you will reach a medical journalistic peak.
Abstracts Pt.44
Authors: Amit Kulkarni, Elizabeth Horn, Rajesh Balkrishnan, Steven Feldman, Angana Mitra, Mark Goodfield, Natalia Mendoza, El Bosque, Adriana Motta, Zsuzsanna Fazekas, Irwin Kantor, Mark Lebwohl, J Am, Acad Dermatol, Chi-Keung Yeung, Henry Hin, Lee Chan, Bruce Strober, Gino Vena, C Coviello
Journal: Journal of the American Academy of Dermatology (2006)
Decreased hepatic nitric oxide production contributes to the development of rat sinusoidal obstruction syndrome
Authors: Laurie D. Deleve, Xiangdong Wang, Gary C. Kanel, Yoshiya Ito, Nancy W. Bethea, Margaret K. McCuskey, Zoltan A. Tokes, Jeffrey Tsai, Robert S. McCuskey
Journal: Hepatology (2003)

This study examined the role of decreased nitric oxide (NO) in the microcirculatory obstruction of hepatic sinusoidal obstruction syndrome (SOS). SOS was induced in rats with monocrotaline. Monocrotaline caused hepatic vein NO to decrease by 30% at 24 hours and by 70% at 72 hours; this decrease persisted throughout late SOS. N G –nitro–L–arginine methyl ester (L–NAME), an inhibitor of NO synthase, exacerbated monocrotaline toxicity, whereas V–PYRRO/NO, a liver–selective NO donor prodrug, restored NO levels, preserved sinusoidal endothelial cell (SEC) integrity and sinusoidal perfusion as assessed by in vivo microscopy and electron microscopy, and prevented clinical and histologic evidence of SOS. NO production in vitro by SEC and Kupffer cells, the 2 major liver cell sources of NO, decreases largely in parallel with loss of cell viability after exposure to monocrotaline. Increased matrix metalloproteinase (MMP) activity increases early on in SOS and this increase in activity has been implicated in initiating SOS. Infusion of V–PYRRO–NO prevented the monocrotaline–induced increase in MMP–9. In conclusion, decreased hepatic NO production contributes to the development of SOS. Infusion of an NO donor preserves SEC integrity and prevents development of SOS. These findings show that a decrease in NO contributes to SOS by allowing up–regulation of MMP activity, loss of sinusoidal integrity, and subsequent disruption of sinusoidal perfusion. (Hepatology 2003;38:900-908).
Abstract 2475: Time Course Of Response To Cardiac Resynchronization Therapy In Patients With Ischemic And Non-ischemic Cardiomyopathy
Authors: Nina Ajmone Marsan, Nico R Van de Veire, Claudia Ypenburg, Gabe B Bleeker, Eduard R Holman, Ernst E van der Wall, Martin J Schalij, Jeroen J Bax
Journal: Circulation (2007)

Background. Cardiac resynchronization therapy (CRT) results in improved left ventricular (LV) systolic function expressed by reduction in LV end-systolic volume (ESV). However, it is still not well known whether this reduction in LVESV occurs immediately after CRT (acute response) or whether some pts need more time to improve in LVESV. Aim of the study was to evaluate the time course of response (improvement in LVESV) to CRT. Particularly, the time course of response was compared between pts with ischemic and non-ischemic cardiomyopathy. Methods. 95 consecutive heart failure pts (84 men; 65±10yrs, 60 pts with ischemic cardiomyopathy and 35 pts with non-ischemic cardiomyopathy) scheduled for CRT, were included. 2D echocardiography was performed before, immediately after CRT and at 6 months follow-up (6MFU) to evaluate LVESV and LV ejection fraction (EF). Results. Immediately after CRT, a significant reduction in LVESV was observed combined with a significant increase in LVEF. At 6MFU a further improvement in LVESV and LVEF was noted (Table ).When a reduction in LVESV&gt;15% was used to define response to CRT, 38% exhibited an acute response, with an additional 18% at 6MFU resulting in a total of 56% responders to CRT. In pts with ischemic cardiomyopathy (63%), 28% exhibited an acute response, with an additional 17% at 6MFU resulting in 45% responders. In non-ischemic pts, 54% (P&lt;0.05 vs ischemic pts) exhibited acute response, with an additional 20% at 6MFU resulting in 74% responders. Conclusions. The beneficial effect of CRT on LV systolic function occurs immediately after CRT implantation, with an additional improvement at 6MFU. Pts with ischemic cardiomyopathy need more time to respond to CRT.
A modified phentolamine test for the diagnosis of pheochromocytoma
Authors: G. Spergel
Journal: JAMA (1970)

The usefulness of phentolamine mesylate in testing for pheochromocytoma is limited by false-positive blood pressure responses in other hypertensive states not characterized by elevated catecholamine levels. Since phentolamine can release the suppression of insulin secretion caused by catecholamines, changes in plasma insulin and glucose levels were measured following phentolamine administration in an attempt to enhance this test's specificity. Three patients with proven pheochromocytoma and positive reactions had a mean fall in glucose value of 52 mg/100 ml and a mean rise in insulin level of 39 microunits/ml. Six patients with false-positive reactions had a mean fall in glucose content of 3 mg/100 ml and a mean rise in insulin value of 7 microunits/ml. Ten patients with negative reactions had similar changes. Thus, these measurements during a modified phentolamine test may identify the falsepositive reactions and strengthen this procedure.
Massachusetts Medical Society
Authors: Benjamin P. W. Ruotolo
Journal: New England Journal of Medicine (1956)

TOXIC HAZARDS*Methyl Chloroform†In an earlier article, the hazards in the use of carbon tetrachloride were pointed out, and trichlorethylene was discussed as a safer substitute. In recent years another substitute also has appeared. Known as methyl chloroform, or 1,1,1, trichlorethane, it is prepared by chlorination of ethyl chloride. With the formula CH3CCl3, methyl chloroform should be distinguished from the time-honored anesthetic chloroform (trichloromethane), which has the formula CHCl3.Methyl chloroform is a colorless, volatile solvent with a pleasant odor. It is slightly toxic and nonflammable. This solvent can be used as a . . .
Lumbar Puncture
Authors: S. F. Gaylord
Journal: JAMA (1979)

<h3>To the Editor.—</h3> In regard to the syndrome of inappropriate secretion of antidiuretic hormone in a recent article (240:856, 1978), the third paragraph states that the optical fundi could not be visualized. On page 857, at the end of paragraph 1, the authors state that the lumbar puncture was refused by the the patient and her family. Perhaps the patient and her family showed good judgment. Lumbar puncture is contraindicated when the optic fundi cannot be visualized, unless a serious diagnosis of meningitis is entertained.
Two recent cases of severe tetanus
Journal: Eurosurveillance (2002)

Two cases of severe tetanus in women aged 61 years with histories of incomplete vaccination were notified in April 2002, the first cases reported sofar this year (1). The first case from West Yorkshire developed symptoms eight days after sustaining a head injury from a fall down stairs. Neither tetanus toxoid nor immunoglobulin was given at the time of her injury, which required stitches. She was admitted to intensive care four days later with respiratory and cardiac arrest, and severe trismus, and died two and a half weeks later. Only one dose of tetanus toxoid given eight years ago was shown in her medical records.
Short cuts: What's new in the other general journals
Authors: Alison Tonks
Journal: BMJ (2005)

potentially useful for patients with poor blood pressure control who are taking three or more drugs.Using the guidelines outlined in this article and restricting the use of spironolactone to 25 mg, we have found the incidence of serious hyperkalaemia and substantial renal dysfunction to be low.By careful monitoring, however, we have also identified occasional serious cases of hyperkalaemia and stopped treatment before adverse events occurred.
Errors in Multiple Sections
Journal: JAMA Neurology (2019)

Hermann Neugebauer, MD, MSc; Hauke Schneider, MD, MBA; Julian Bösel, MD; Carsten Hobohm, MD; Sven Poli, MD; Rainer Kollmar, MD; Jan Sobesky, MD; Stefan Wolf, MD; Miriam Bauer; Sascha Tittel, MSc; Jan Beyersmann, Dr rer nat; Johannes Woitzik, MD; Peter U. Heuschmann, MD; Eric Jüttler, MD, MSc
TRADES UNIONISM AMONG HOSPITAL ATTENDANTS.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The care of patients with severe chronic pain in terminal illness
Authors: W. T. McGivney
Journal: JAMA (1984)

The care of terminally ill patients with severe chronic pain should provide treatment that permits these patients to close their lives with dignity and purpose. Analgesics, both opioid and nonopioid, are available and when properly used can provide effective relief of pain for most terminally ill patients. It is incumbent on the physician and on all others who care for the dying patient with severe chronic pain to understand clearly the dynamics of the pain experience, the clinical pharmacology of analgesics, and the needs of the patient, family, and friends. (<i>JAMA</i>1984;251:1182-1188)
Le dualisme de la contraction cardiaque: Recherches expérimentales du laboratoire de thérapeutique de l'Université de Liége
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Asymptomatic Gonorrhea
Authors: Richard W. Thatcher
Journal: JAMA (1969)

Asymptomatic gonorrhea in females and males does exist, and its incidence depends on the group studied. Those groups with the greatest chance of exposure to gonorrhea have the highest percentage of asymptomatic gonorrhea. In a routine physical examination of 505 military personnel, who all were asymptomatic for gonorrheal infections, cultures of the urethra, rectum, and pharynx were obtained to determine the presence of gonococcus and meningococcus. Neither<i>Neisseria gonorrhoeae</i>nor<i>N meningitidis</i>was recovered from the urethral or rectal cultures. Seventy-four male patients (14.6%) had the meningococcus recovered from the pharynx, and one had the gonococcus recovered from the pharynx.
Correction
Journal: BMJ (1894)

J. D. M. asks whether a soft water, free from organic impurities, but con- taining 41.5 parts of carbonate soda per 100,000, is to be regarded as wholesome; and, if not, how it can be rendered so ?INQUIRER asks for advice as to the choice of a climate favourable to a patient suffering from from frequent attack of migraine.The patient gas for some years been living in Norfolk, perhaps too dry and bracing a county.She has now the choice of residing in any of the following places: Derby, Bedford, Weymouth, Reading, Dunstable, Worcester, Leamington, Abingdon, Jersey, Guernsey, and London.J. H. asks for suggestions in the treatment of a patient who complains of "coated tongue and a sweetish taste in the.mouth."This has lasted for years, and there are no other symptoms of digestive disorder, the patient being otherwise in apparently good health.Various remedies have been tried, including calomel, rhubarb, and saline purgatives, but with no apparent benefit.M. 0. writes: I should feel greatly obliged if any of your readers could give me a list of books (,I) treating of the fevers of India, (2) tropical diseases, and (3) syphilitic diseases of the nervous system.Nos. ( 1) and ( 2) are required as works of reference in writing a thesis on the subject.**V There has been no book on the fevers of India published since Fayrer's Climate and Fevers of India, and in it the subject is not treated of from the standpoint of the malaria organism of Lavcran.Chevers, Moore, Maclean, Aitken, Morehead, Martin, Annesley-all treat of the fevers of India.(I) Tropical diseases: Davidson's Hygiene and Diseases of Warm Climates is the most recent; Corre's Maladies des Pays Chauds and Roux on the same subject are the most recent French works.Our correspondent will find amplebibliographies In all of these works-parti cularly in the French works.
CALCIUM IN THE URTICARIAS
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
History of Medicine and Surgery and Physicians and Surgeons of Chicago.
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Commentary
Authors: P Watts
Journal: British Journal of Sports Medicine (2000)

Objective-To identify the physiological and anthropometric determinants of sport climbing performance.Methods-Forty four climbers (24 men, 20 women) of various skill levels (self reported rating 5.6-5.13c on the Yosemite decimal scale) and years of experience (0.10-44 years) served as subjects.They climbed two routes on separate days to assess climbing performance.The routes (11 and 30 m in distance) were set on two artificial climbing walls and were designed to become progressively more diYcult from start to finish.Performance was scored according to the system used in sport climbing competitions where each successive handhold increases by one in point value.Results from each route were combined for a total climbing performance score.Measured variables for each subject included anthropometric (height, weight, leg length, arm span, % body fat), demographic (self reported climbing rating, years of climbing experience, weekly hours of training), and physiological (knee and shoulder extension, knee flexion, grip, and finger pincer strength, bent arm hang, grip endurance, hip and shoulder flexibility, and upper and lower body anaerobic power).These variables were combined into components using a principal components analysis procedure.These components were then used in a simultaneous multiple regression procedure to determine which components best explain the variance in sport rock climbing performance.Results-The principal components analysis procedure extracted three components.These were labelled training, anthropometric, and flexibility on the basis of the measured variables that were the most influential in forming each component.The results of the multiple regression procedure indicated that the training component uniquely explained 58.9% of the total variance in climbing performance.The anthropometric and flexibility components explained 0.3% and 1.8% of the total variance in climbing performance respectively.Conclusions-The variance in climbing performance can be explained by a component consisting of trainable variables.More importantly, the findings do not support the belief that a climber must necessarily possess specific anthropometric characteristics to excel in sport rock climbing.
Journal of Bacteriology, Baltimore
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
DIET AND DETERIORATION AMONG THE AMERICAN INDIANS
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal