tbuckley/cabot-search huggingface dataset:
Scary Scenarios Spark Action at Bioterrorism Symposium
Authors: C. Marwick
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Transactions of the Texas State Medical Association.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A DIRECTOR-GENERAL OF PUBLIC HEALTH.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
IgA nephropathy
Authors: D G Williams
Journal: BMJ (1994)

to decisions on treatment.Thirdly, meta-analyses should incorporate estimates of the risk in the included trials to examine whether systematic differences in benefit are seen in relation to the degree of risk of participants in the trials.8Finally, since those who gain the most from medical treat- ment are those who have most to gain, the irrationality of current suggestions that population groups at increased risk of disease-such as smokers-should not be treated should be recognised.
NEW IDEAS CONCERNING APHASIA.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PAS, the Acronym of Periodic Error
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
LARGE DOSES OF CARBOLIC ACID GIVEN WITH IMPUNITY.NEW LIGHT ON MALARIA.
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
In Reply
Authors: Brian E. Lally, Daniel Zelterman, Joseph M. Colasanto, Bruce G. Haffty, Frank C. Detterbeck, Lynn D. Wilson
Journal: Journal of Clinical Oncology (2007)

widely used until 1995 or later, and positron emission tomography was not prevalent until after 2000).Indeed, we do not know even today what the appropriate target or dose might be.Evidence now strongly supports the use of systemic therapy, for those patients who can tolerate it, in patients with stage N1 and N2 NSCLC completely resected for cure.This evidence is based on cisplatin therapy, and strongest for cisplatin combined with vinorelbine. 6,7 Neither the Lally et al article nor the Bonner and Spencer editorial emphasize that outside of the United States virtually no one uses carboplatin plus paclitaxel, which has never demonstrated superiority of the combination over older two-drug platinum-based combinations or newer ones with vinorelbine 7,8 in prospective trials with comparative arms.Instead, championing the use of PORT based on uncontrolled retrospective studies not using the current standard, Bonner and Spencer, and the Lally et al article by inference, justify the use of a marginally effective modality (PORT) without mentioning the new standard (postoperative chemotherapy).Also, pattern of failure cannot be assessed from the SEER data, nor can any of the radiotherapy variables that were so heavily criticized in the PORT meta-analysis.There is a prospective trial of postoperative therapy, which permits neoadjuvant or adjuvant chemotherapy, developing in Europe, but none emerging in the United States.As in the Adjuvant Navelbine International Trialist Association and International Adjuvant Lung Cancer trials, 7,8 we may need international cooperation to complete a trial for N1 and N2 patients.We would propose that a PORT trial should give at least two cycles of cisplatin-based therapy (preferably with vinorelbine), exclude ERCC1-positive patients, and randomly assign patients to either PORT or two additional cycles of chemotherapy.The PORT group could sequence cycle 3 and 4 chemotherapy after the radiotherapy as an option.The end point should be primarily survival, with local control as a secondary end point.We all hope for gene profiles to identify prognostic groups, or factors that predict response to therapy.ERCC1 may predict survival (with ERCC1-negative tumors associated with poorer prognosis).However, cisplatin-based chemotherapy was detrimental in the ERCC1-positive group. 8
Reversion by interferon of liver fibrosis and damage induced by biliary obstruction in the rat Departamento de Farmacologia y Toxicologia, Centro de Investigaci�n y de Estudios Avanzados del I.P.N., M�xico, D.F., M�xico
Journal: Hepatology (1995)

Secretin not only increases ductular bile secretion in vivo in rats after bile duct ligation (BDL) [1], but also increases cAMP levels and stimulates exocytosis in isolated cholangiocytes [2]. Although we have previously reported that secretin receptor mRNA was upregulated in cholangiocytes after BDL [3], the cholangiocyte secretin receptor has not been functionally characterized or quantified after BDL. In this work, we used a novel, photolabile and biologically active analogue of secretin to quantify and characterize secretin receptors on cholangiocytes isolated from normal and BDL rats. The cholangiocyte secretin receptor bound radioligand with high affinity and in a rapid, reversible, and temperature-dependent manner. While receptors on cholangiocytes from normal and BDL rats were functionally and biochemically identical, receptor density on cholangiocytes was increased 5-fold following BDL. The combination of increased cell number with increased functional secretin receptors per cell is due to the fact that cholangiocyte hyperplasia represents a reactive response to a cholestatic condition and this effort on the part of the organism to maintain bile secretion, explains the increased hormone-responsive choleresis observed after BDL and may reflect an adaptive response of the organism to cholestasis.
The Effect of Aging of Population on General Health Problems
Authors: Robert T. Monroe
Journal: New England Journal of Medicine (1953)

HEART disease occurs in some form and degree in the majority of aging men and women (Table 6). Many of the greatest advances in internal medicine in recent times have been made in this whole area, and though heart disease remains the leading cause of death, enormous improvements have been made in lessened disability and longer life expectancy. Only a few points need to be emphasized here. Most important is the fact that old people with heart disease are not constantly in danger or disabled by it. Heart failure and coronary-artery occlusion are serious; they may be fatal, but if . . .
Endemic Typhus
Authors: C. G. Baker, G. T. L. Archer, G. B. Mitchell-Heggs
Journal: BMJ (1943)

The map showing the recent distribution of the fevers of the typhus group in the Epidemiological Report of the Health Section of the League of Nations, 1936, suggests that these have not been recorded in Madagascar, and the local French public health report, 1940, states that this group of diseases does not occur on the island.It is therefore felt that the following series of cases among Service units, though small, justifies a special record.The general hospital was functioning with limited equipment in Madagascar for several months after May, 1942.There were a considerable number of cases with pyrexia of uncertain origin, with and without a rash, to which an accurate label could not be attached, as no agglutinable suspensions were available.Soon after the arrival of the suspensions a patient was admitted to hospital suffering from severe headache, drowsiness, backache, pains in chest, and a productive cough.This case was first diagnosed as bronchopneumonia, but sulphapyridine had no effect, for his fever continued and he remained seriously ill.For this reason, and despite negative blood films, it was thought that he might have malaria as well, and so was given quinine.On the seventh day a macular rash developed, and his bloated appearance with suffused eyes, taken in conjunction with the course of his illness, led to a suspicion that the case was one of typhus (C.G. Baker).This was confirmed by the Weil-Felix test (G.T. L. Archer).Patients in the hospital with indefinite fever-in some cases with a rash and severe malaise, in others only slightly ill, but all from the same unit and area-were immediately examined again, and blood agglutination performed.The early results of Weil-Felix examination were as follows:Case 1: OX19, OX2, OXK, 1/100 on 11th day ,, 2: OX19 1/400, OX2=0, OXK=0, on 12th day
CAPILLARY BRONCHITIS.
Authors: PHILIP F. BARBOUR
Journal: JAMA (1903)

The tendency of the bronchitis which involves the smaller bronchi to invade the air cells, thus producing a pneumonia, has only recently been generally recognized, but with this more exact knowledge of the pathology of bronchopneumonia the profession has come to look on the accompanying pneumonia as the important condition to be treated. Yet all will agree that in many cases pneumonia is the lesser factor and that the bronchial mucous membrane, with its outpour of mucus into the smallest bronchioles, constitutes the real danger to the child. The older writers called attention to this condition under the designation "capillary bronchitis," an expression which, unfortunately, has fallen into innocuous desuetude, for no other term conveys exactly the same impression to us. It is the extent of the involvement rather than any pathologic difference that makes capillary bronchitis more to be feared than even catarrhal or croupous pneumonia.
Subungual lipoma
Authors: F. Bardazzi, F. Savoia, P.A. Fanti
Journal: British Journal of Dermatology (2003)

Journal Article Subungual lipoma Get access F. Bardazzi, F. Bardazzi Department of Clinical and Experimental Medicine, Division of Dermatology, University of Bologna, via Massarenti, 140138, Bologna, Italy Dott. Federico Bardazzi. E‐mail: fbardazzi@orsola‐malpighi.med.unibo.it Search for other works by this author on: Oxford Academic Google Scholar F. Savoia, F. Savoia Department of Clinical and Experimental Medicine, Division of Dermatology, University of Bologna, via Massarenti, 140138, Bologna, Italy Search for other works by this author on: Oxford Academic Google Scholar P.A. Fanti P.A. Fanti Department of Clinical and Experimental Medicine, Division of Dermatology, University of Bologna, via Massarenti, 140138, Bologna, Italy Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 149, Issue 2, 1 August 2003, Page 418, https://doi.org/10.1046/j.1365-2133.2003.05370.x Published: 01 August 2003 Article history Accepted: 04 December 2002 Published: 01 August 2003
Effective Asparagine Depletion with Pegylated Asparaginase Results in Improved Outcomes in Adult Acute Lymphoblastic Leukemia (ALL) — Cancer and Leukemia Group B Study 9511.
Authors: Meir Wetzler, Ben L. Sanford, Kouros Owzar, Joanne Kurtzberg, D. DeOliveira, Stanley R. Frankel, Bayard L. Powell, Jonathan E. Kolitz, Clara D. Bloomfield, Richard A. Larson
Journal: Blood (2005)
Abstract 214: S100A6 Promotes Myocyte Survival by Interacting with the Receptor for Advanced Glycation End Products and Activating Akt
Authors: James Tsoporis, Shehla Ruby, Thomas G Parker
Journal: Circulation (2008)

The receptor for advanced ligation end-products (RAGE) recognizes ligands from diverse families including the S100 calcium binding proteins S100A6 and S100B. In a rat model of myocardial infarction, we have reported the induction of S100B, the upregulation of S100A6 and RAGE mRNA and protein in peri-infarct left ventricular (LV) myocardium, increases in S100B and S1006 serum levels and demonstrated a direct interaction between S100B and S100A6 with RAGE in peri-infarct LV myocardium. To determine the functional role of the interaction of S100A6 and S100B with RAGE, we stimulated rat neonatal cardiac myocyte cultures transfected with a RAGE gene or a dominant-negative cytoplasmic deletion mutant of RAGE with S100B and/or S100A6 for 48 hrs. In RAGE overexpressing myocytes, although both S100 proteins induced the formation of reactive oxygen species, S100B &gt; 10 nM induced myocyte apoptosis, as evidenced by increased terminal deoxynucleotidyltransferase-mediated UTP end labeling (TUNEL), FITC annexin V flow cytometry, cytochrome C release, phosphorylation of ERK1/2 and p53, and increased activity of caspase-3, whereas S100A6 &lt; 10 nM inhibited basal myocyte apoptosis, increased the phosphorylation of Akt and the expression of NF-κB and in combination with S100B inhibited S100B-induced myocyte apoptosis [6.3±0.9% (vehicle), 16.1±0.1.2% (S100B), 4.1±0.4% (S100A6), 6.4±1.5% (S100B+S100A6) (TUNEL positive nuclei)]. The upstream Akt blocker LY294002, inhibited the RAGE dependent anti-apoptotic effects of S100A6 on basal- and S100B-induced myocyte apoptosis. In myocytes expressing dominant-negative RAGE, the contrasting effects of S100B and S100A6 on myocyte apoptosis were absent regardless of Akt inhibition. In conclusion, in a RAGE-dependent manner, S100A6 inhibits myocyte apoptosis via Akt activation.
A human liver cell-based system modeling a clinical prognostic liver signature combined with single cell RNA-seq for discovery of novel liver disease therapeutics
Authors: Emilie Crouchet, Simonetta Bandiera, Naoto Fujiwara, Shen Li, Hussein El Saghire, Xiaochen Sun, Hadassa Hirschfield, Natascha Roehlen, Frank Jühling, Antonio Saviano, Victor Gonzalez-Motos, Anu Venkatesh, Clara Ponsolles, Eloi Verrier, Nicolaas Van Renne, Joachim Lupberger, Christine Thumann, François H.T. Duong, Shijia Zhu, Mozhdeh Sojoodi, Ricard Masia, Lan Wei, Marine Oudot, Sarah Durand, Shigeki Nakagawa, Atsushi Ono, Won-Min Song, Takaaki Higashi, Roberto Sanchez, Rosa S. Kim, C. Billie Bian, Karun Kiani, Tom Croonenborghs, Aravind Subramanian, Raymond Chung, Danijela Heide, Jenny Hetzer, Beate Straub, Detlef Schuppan, Maliki Ankavay, Laurence Cocquerel, Evelyne Schaeffer, Nicolas Goossens, Anna P. Koh, Milind Mahajan, Venugopalan D. Nair, Ganesh Gunasekaran, Myron Schwartz, Nabeel Bardeesy, Alex K. Shalek, Orit Rozenblatt-Rosen, Aviv Regev, Mathias Heikenwalder, Emanuele Felli, Patrick Pessaux, Kenneth K. Tanabe, Catherine Schuster, Nathalie Pochet, Mirjam Zeisel, Bryan C. Fuchs, Yujin Hoshida, Thomas Baumert
Journal: Journal of Hepatology (2020)
Postoperative Airway Maintenance
Authors: William K. Hamilton
Journal: JAMA (1966)

A 12-year-old white boy was admitted to the hospital with a three weeks' history of recurrent epistaxis. Nasal obstruction on the right side had been noted for two to three years. A review of systems was otherwise noncontributory. Abnormal findings on physical examination were confined to the right nasopharynx, where a 2 × 2cm polypoid mass was visualized. Laboratory findings included normal results of urinalysis; hemoglobin, 12.5 gm/100 ml; white blood cell count, 7,300, with a normal differential count. The preoperative diagnosis was nasopharyngeal angiofibroma. The day following admission premedication with sodium pentobarbital (Nembutal) and scopolamine hydrobromide was given one hour prior to surgery. Induction with halothane, nitrous oxide, and oxygen was uneventful. The trachea was intubated with a cuffed endotracheal tube, and the nasopharyngeal fibroma was removed with a rongeur forceps. Bleeding was copious for a few minutes, but was controlled by a posterior nasal pack of lamb's wool.
Postcoital Contraception
Authors: JOHN MCLEAN MORRIS
Journal: Annals of Internal Medicine (1970)

Letters and Comments1 October 1970Postcoital ContraceptionJOHN MCLEAN MORRIS, M.D.JOHN MCLEAN MORRIS, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-73-4-656_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In view of the correspondence between Drs. Paulshock, Andersen, and Hayman and particularly Dr. Hayman's statement, "I know of no reports in the literature showing that estrogen has been administered to humans directly after insemination and has prevented nidation" (Ann Intern Med72:961, 1970), it might be worth calling your readers' attention to the two articles from our Department (1, 2). I believe the doses of estrogen suggested by Drs. Paulshock and Andersen are too small to give consistent protection against pregnancy. Fifty milligrams of diethylstilbestrol (Stilbestrol®) a day for 5 days appears to be effective; 20...References1. MORRISVAN WAGENEN JG: Compounds interfering with ovum implantation and development. III. The role of estrogens. Amer J Obstet Gynec 96:804-813, 1966 CrossrefMedlineGoogle Scholar2. MORRISVAN WAGENEN JG: Post-coital oral contraception, in Proceedings of the International Planned Parenthood Federation, Santiago, Chile, 9-15 April 1967 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JOHN MCLEAN MORRIS, M.D.Affiliations: Department of Obstetrics and Gynecology Yale University School of Medicine 333 Cedar St. New Haven, Conn. 06510 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byA Comparative Endocrinological and Pharmacological View of the Maintenance or Interruption of PregnancyPhysiology and pharmacology of female reproduction under the aspect of fertility control 1 October 1970Volume 73, Issue 4Page: 656-656KeywordsContraceptivesEstrogensPregnancy ePublished: 1 December 2008 Issue Published: 1 October 1970 PDF downloadLoading ...