tbuckley/cabot-search huggingface dataset:
01.01 S100A8/a9 increases the mobilisation of LY6C high monocytes to the synovium during experimental osteoarthritis
Authors: Niels Cremers, Edwin Geven, Arjen Blom, Annet Sloetjes, Irene DiCeglie, Stephanie van Dalen, Martijn van den Bosch, Peter van der Kraan, Peter van Lent
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Low grade synovitis characterised by monocyte influx has been associated with joint pathology in inflammatory osteoarthritis (OA). Alarmins S100A8/S100A9 are highly increased in the synovium after induction of experimental inflammatory OA and remain elevated for prolonged periods. Release of S100A8/A9 locally within the OA-joint and leakage into the blood may contribute to recruitment of monocytes. In mice, two functionally distinct monocyte populations are described: pro-inflammatory Ly6C<sup>high</sup> and patrolling Ly6C<sup>low</sup> monocytes. Our <b>objective</b> was to investigate the role of S100A8/A9 in the recruitment of the different monocyte populations during collagenase-induced OA (CiOA). <h3>Methods</h3> CiOA was induced by injection of collagenase in knee joints of wild type C57BL/6 (WT), and S100A9KO mice. After 7 days, mice were sacrificed together with age-matched saline-injected control mice (n=6/group), and expression of chemokines, and adhesion molecules were measured in the synovium, and bone marrow (BM). Cells were isolated from BM and synovium and analysed by FACS. Monocytes were identified as (B220/CD90/CD49b/NK1.1/Ly6G)<sup>low</sup>CD11b<sup>high</sup>(F4/80/MHCII/CD11c)<sup>low</sup>, which were further divided into subsets based on their Ly6C expression. <h3>Results</h3> At CiOA d7 in WT mice, numbers of Ly6C<sup>high</sup>, but not Ly6C<sup>low</sup> monocytes, were strongly increased (7.6-fold) in the synovium when compared to saline-injected controls. In contrast, S100A9KO mice showed a significant increase in Ly6C<sup>low</sup> monocytes (2-fold) at CiOA d7, whereas the number of Ly6C<sup>high</sup> monocytes remained unaffected. Although a strong upregulation of several chemokines (MCP1, CX3CL1, KC, and MIP1α) was observed in the synovium at CiOA d7, there were no differences in expression between WT and S100A9KO mice. Next we studied the effect of S100A8/A9 on the BM during CiOA. We found a 14% decrease of myeloid cells in WT BM at CiOA d7, whereas the number of myeloid cells in S100A9KO BM was not changed, suggesting that S100A8/A9 released by the inflamed synovium promotes the release of myeloid populations from the BM. In line with that, expression of adhesion molecules (LFA-1, VCAM, VE-cadherin, PECAM1, and l-selectin) was lower at CiOA d7 in S100A9KO BM when compared to WT BM. <h3>Conclusions</h3> Local induction of OA leads to S100A8/A9 production and mobilises influx of particularly Ly6C<sup>high</sup> monocytes, which contribute to OA pathology.
Prospective study of cognitive function (cog fcn) in women with early-stage breast cancer (ESBC): Predictors of cognitive decline.
Authors: Hope S. Rugo, Amy N. DeLuca, Lara Heflin, Sally Fang, Michelle E. Melisko, Mark M. Moasser, John W. Park, Amy Jo Chien, Pamela N. Munster, Laura Esserman, Susan M. Landau, William J. Jagust, Joel H. Kramer
Journal: Journal of Clinical Oncology (2013)

104 Background: Cog complaints are common among women receiving adjuvant therapy (Rx) for ESBC. Longitudinal prospective data is needed to help identify predictors of cog decline. We conducted a prospective trial to evaluate the effects of chemo- (CTX) and hormone therapy (HRx) on brain and cog fcn in pts with ESBC using multiple objective and subjective tests as well as MRI/PET imaging. Here we report evaluation of clinical characteristics that predict decline in cog fcn. Methods: Eligibility included female patients (pts) planning to receive adjuvant Rx for ESBC. Pts were enrolled in 3 Rx groups (grps): CTX, CTX and HRx, and HRx, with a 4 th no Rx age/education matched control grp. All pts underwent a battery of objective and subjective cog tests before start of Rx, 1 mo after CTX or 5 mo after start of HRx (FU1), then 9 mo (FU2) and 18 mo (FU3) after CTX. Brain MRI, PET and serum estradiol (E) were performed at baseline, FU1 and FU2. Results: 81 pts were enrolled as follows, 14 CTX, 33 CTX and HRx, 22 HRx, 12 control. 90% completed FU1, 72% FU2, and 62% FU3, with 29 pts waiting to complete testing. Demographics were similar between grps, median age 54, 78% Caucasian. At each FU, ~25% of pts showed decline in cog fcn compared to the prior time point using a reliable change index; 51% showed decline at &gt; 1 time point, primarily in tests measuring executive function and verbal memory. 62% of pts who declined from baseline to FU1 later stabilized or improved; 77% of pts who declined from FU1 to FU2 later stabilized or improved. Compared to controls, receipt of CTX and HRx (OR 3.15, p=.008), or HRx overall (OR 4.94, p=.004) but not serum E, menopausal status, or CTX, were significant predictors of decline at any time point. Rx group did not predict poorer perceived cog fcn (FACT-COG); depression and fatigue did not predict decline in objective cog fcn. Conclusions: Decline in cog fcn is common in pts receiving adjuvant Rx for ESBC. Predictors included CTX and HRx, or HRx overall but not other treatment and pt related factors. Ongoing HRx, particularly after CTX, appears to be a risk factor for worse cog fcn. Pts should be aware that HRx may be a risk factor for cog deficits, and intervention studies should be designed to focus on this group of pts. Funding: NIH R01 1AG025303-01A2. Clinical trial information: 00755313.
Reflections on the Doctor's Anguish
Authors: Peggy L. Wros
Journal: Annals of Internal Medicine (1993)

Letters1 January 1993Reflections on the Doctor's AnguishPeggy L. Wros, MSN, RNPeggy L. Wros, MSN, RNOregon Health Services University; Portland, OR 97201Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-118-1-199301010-00029 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Edwards and Tolle are to be congratulated for bringing this sensitive issue to the forefront for discussion. However, I was struck by the absence of the nurses in the description.In my ongoing study of nursing care of dying patients, critical care nurses describe a common scenario in which a physician writes an order for extubation and sedation and then leaves the unit. The nurse is left to deal with the technical aspects of discontinuing life-sustaining technology, providing comfort, and supporting the patient or family as the patient dies. Evidence suggests that nurses initially experience some of ... Author, Article, and Disclosure InformationAffiliations: Oregon Health Services University; Portland, OR 97201 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 January 1993Volume 118, Issue 1Page: 78-80KeywordsAnxietyCritical careEmotionsExtubationNursesPatientsSedation ePublished: 15 August 2000 Issue Published: 1 January 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Book Review Psychosomatic Medicine: The clinical application of psychopathology to general medical problems . By Edward Weiss, M.D., and O. Spurgeon English, M.D. 8°, cloth, 687 pp., with 2 tables, 9 illustrations and 4 charts. Philadelphia and London: W. B. Saunders Company, 1943. $8.00.
Journal: New England Journal of Medicine (1943)
The Exercise Tolerance Test
Authors: Crawford W. Adams
Journal: JAMA (1968)

<h3>To the Editor:—</h3> As stated in my original answer to Dr. Harris' question, a test of "exercise tolerance" implies a challenge to the coronary circulation. In all age groups there is considerable variability of exercise performance. The work load produced by the single or double Master's two-step test is frequently inadequate to demonstrate diagnostic electrocardiographic changes in a physically fit individual even though he may have underlying coronary artery disease. Despite Master's attachment to the wooden steps, the trend is toward the more reproduceable application of the work load either with the treadmill or bicycle ergometer. Approximately 40% of patients in whom there is acute myocardial infarction or sudden death have no previous clinical evidence of underlying coronary artery disease.<sup>1</sup>Therefore, the coronary-prone individual must be detected before infarction occurs. A carefully monitored graded exercise test is easily performed and detects a high percentage of the coronary-prone individuals by
Alterations in Sexually Dimorphic Biotransformation of Testosterone in Juvenile American Alligators (Alligator mississippiensis) from Contaminated Lakes
Authors: Mark P. Gunderson, Gerald A. LeBlanc, Louis J. Guillette
Journal: Environmental Health Perspectives (2001)

The goal of this study was to determine whether hepatic biotransformation of testosterone is normally sexually dimorphic in juvenile alligators and whether living in a contaminated environment affects hepatic dimorphism. Lake Woodruff served as our reference site. Moonshine Bay, located on the west side of Lake Okeechobee, served as an intermediate site. Lake Apopka, the Belle Glade area located at the south end of Lake Okeechobee, and Water Conservation Area 3A, in the northern Everglades, served as our contaminated sites (all lakes are in Florida). Normal testosterone hydroxylase activity exhibited sexually dimorphic patterns of expression, with reference animals from Lake Woodruff exhibiting a female:male ratio of 1.44. This pattern was perturbed in all of the intermediate and contaminated sites investigated. Normal testosterone oxido-reductase activity exhibited sexually dimorphic expression (Lake Woodruff female:male ratio of 1.45). This pattern was altered in all contaminated sites investigated. UDP-Glucuronosyltransferase activity exhibited no sexually dimorphic pattern in animals collected from our reference site, with Lake Woodruff animals exhibiting a female:male ratio of 1.06. This pattern was perturbed in animals from Water Conservation Area 3A, which exhibited a female:male ratio of 0.65. Sulfotransferase activity demonstrated no sexual dimorphism at any of the sites investigated, although elevated activity was observed in males from the Lake Okeechobee watershed compared to those from Lake Woodruff. These data demonstrate different patterns of hepatic androgen biotransformation in animals living in contaminated environments.
TEST OF PHYSICAL EFFICIENCY
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Evaluation of Mesoridazine
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE INFLUENCE OF OUR SCHOOL SYSTEM ON THE HEALTH AND DEVELOPMENT OF THE CHILD.
Authors: E. STUVER
Journal: JAMA (1897)

The strength, happiness, prosperity and stability of nations and races almost entirely depend on their hereditary heritages and their ability successfully to adapt themselves to their environment. The whole history of man's development from the earliest times conclusively proves that his highest welfare is conditioned on the harmonious development of all his powers, physical, intellectual and moral, and that when one or more of these have been slighted or neglected, he has paid a dear penalty for such neglect. Glancing down through the ages, we behold untold misery and innumerable wrecks caused by the violation of this inexorable law of nature. Here we see ignorance or disregard of sanitary laws followed by pestilence, disease, lowered vitality, degeneration and extinction; there we behold licentiousness, debauchery and immorality in all its varied forms, produce a similar result. Nor are the most striking examples taken from savage or barbarous peoples, but furnished by
Medical schools in Canada
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Text-Book of Hygiene.
Authors: None C. E. W.
Journal: JAMA (1885)

This book is a valuable compilation of the most important matters relating to the subject of hygiene. It is comprehensive in scope, well condensed, clear in style, and abundantly supplied with references. A work of this sort is necessary and will undoubtedly be improved by future editions. In the consideration of the matter of ventilation the author is somewhat at fault. He assumes the general principle that foul air rises, and recommends rules for ventilation accordingly. The fact is, that in artificially heated buildings of all classes, public as well as private, the middle layer of air is that containing the least impurity and the best adapted as to temperature and humidity to the use of the inhabitants. Impurities that rise can not be dangerous, as they occupy an inaccessible part of the room, while the denser impurities and cold air resulting from the loss of heat by connection as
New and Nonofficial Remedies, 1934, Containing Descriptions of the Articles which Stand Accepted by the Council on Pharmacy and Chemistry of the American Medical Association on January I, 1934
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CASTRATION RECOMMENDED AS A SUBSTITUTE FOR CAPITAL PUNISHMENT.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ranitidine and Cimetidine
Authors: William O. Frank
Journal: JAMA (1984)

<h3>To the Editor.—</h3> It is to be expected that a review of the recently approved H2-receptor antagonist, ranitidine, include reference to cimetidine, the pioneer drug in this group. We believe, however, that in so doing, in his recent article on ranitidine appearing inThe Journal, Strum<sup>1</sup>has rendered a disservice not only to cimetidine but to the readers as well. The data he has chosen to present, plus his selection of contrasts and comparisons of the two drugs, have resulted in an unfairly balanced article to the detriment of cimetidine and one that is misleading in regard to both drugs. This imbalance is most prominent in the sections of the article dealing with efficacy and adverse effects. In the "Pharmacokinetics" section, Dr Strum's discussion of a 100-mg dose of ranitidine seems irrelevant inasmuch as ranitidine is available only as a 150-mg tablet. He does not mention whether the data
OBSERVATIONS ON BACILLUS BOTULINUS INFECTION OF CANNED SPINACH
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Heavy cigarette smoking and RA
Journal: Annals of the Rheumatic Diseases (2002)

In an article on Rubens' painting "The Three Graces" Dequeker suggests that hypermobility is a medical explanation of the seeming scoliosis and Trendelenburg sign in the middle figure . 1 But the posture of this middle figure should probably be interpreted as an artistic phenomenon without medical reference.Sculptors in classical Greek and Roman periods often used the contrapposto posture.In this, by putting most weight on one leg, the other leg can be shown in a relaxed and semiflexed position.This undulating between tension and relaxation will animate the figure.A person with normal muscular function and a normal back can perfectly well pose in this way with relaxed hip abductors on the weightbearing side, a descending hip on the opposite side, and a compensating scoliotic posture.This posture is facilitated by support from the arm as in Rubens' painting.If the person tries to take a forward step, relaxation of the muscles of the weightbearing hip can no longer be maintained, and the positive Trendelenburg sign will disappear.In the Renaissance period the use of this contrapposto posture was revived.During his stay in Rome Rubens eagerly studied the then recently excavated Laokoön sculpture with its three distorted figures. 2 He often used such distorted postures in his paintings to give the impression of vigorous muscular characters capable of performing great tasks.The best example is probably "The Debarkation at Marseilles" in the Maria de Medici cycle from 1622 to 1625 for the Luxembourg Palace in Paris. 3 Here, three young women, nereides, with curved muscular backs at the bottom of the picture nearly seem to carry the ship of Maria de Medici.