tbuckley/cabot-search huggingface dataset:
Gynecology
Authors: Richard R. Curtin, Howard Ulfelder
Journal: New England Journal of Medicine (1959)

CancerAlthough many advances have been made in the treatment of malignant lesions of the female genitalia, surgery and radiation remain the only methods that can "cure" the disease. These methods are being applied with better results in long-term survival and in comfort of the patient, the latter being an important but less often emphasized part of the physician's role. In some human cancers there is much discussion these days about whether earlier treatment is a significant factor in the over-all result of therapy. In cancers of the vulva, cervix, body of the uterus and ovaries, the stage of the . . .
Abstract 3379: Assessment of tumor mutation burden using a novel panel design strategy utilizing highly mutated genomic regions
Authors: Amrita Pati, Daniel Klass, Zhongyun Huang, Melissa Loyzer, Alex Lovejoy
Journal: Cancer Research (2019)

Abstract Background Tumor Mutation Burden (TMB) has grown in importance as a predictive biomarker for predicting response to check-point immunotherapy in several cancer disease areas such as non-small cell lung cancer (NSCLC) and melanoma. Although TMB derived from analysis of WES data is the current gold standard measure of the number of neoantigens in the system, WES is often cost-prohibitive as a routine practice for clinical interpretation. Targeted panels offer a more flexible and cost-effective option, but TMB estimates based on these subsets of the exome can be more variable and often disagree with each other. Current best practices for TMB panels advocate for panels with sizes of 1 Mb with high correlation between panel-derived TMB and WES TMB demonstrating effectiveness of a panel at assessing TMB accurately. Methods We present a systematic approach to designing panels for detecting TMB effectively while minimizing cost of sequencing, based on our Surveillance panel design algorithm. Our approach relies on the prioritization of highly recurrent non-driver mutations present in large cohorts (such as TCGA) for disease areas of interest. Such an approach greatly boosts the number of observations of short variants using a targeted panel while still meeting expectations outlined within current best practices such as a high correlation with WES-derived TMB, and high PPA and NPA with WES-derived TMB. Our NGS based workflow combines whole genome library preparation, hybrid capture target enrichment, high-throughput sequencing and a proprietary analysis algorithm that utilizes short exonic variants that are likely to be somatic. Results Using a combination of in silico data and clinical cohorts, we demonstrate the effectiveness of the above approach in designing panels for the assessment of TMB. Results show high correlations between panel-derived TMB and WES-derived TMB at panel sizes as low as 450Kb while highlighting the steady decrease in variability of the TMB score as panel size increases. We apply this panel and WES analysis to clinical NSCLC and CRC samples to demonstrate that recommendations from current best practices are met in terms of PPA and NPA with WES-derived TMB and high correlation with WES-derived TMB. Citation Format: Amrita Pati, Daniel Klass, Zhongyun Huang, Melissa Loyzer, Alex Lovejoy. Assessment of tumor mutation burden using a novel panel design strategy utilizing highly mutated genomic regions [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3379.
INTRACRANIAL PRESSURE IN DISEASE
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Revue Médicale de Liège
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Declines in Lung Cancer Rates--California, 1988-1997
Journal: JAMA (2000)

Cigarette smoking is the leading cause of lung and bronchus cancer (1). During 1988-1997, per capita cigarette smoking in California declined more than twice as rapidly compared with the rest of the country (2). To characterize lung cancer incidence in California, data from the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) program were compared with data from the population-based California Cancer Registry (CCR). This report summarizes the results of that analysis, which indicated that during 1988-1997, age-adjusted lung cancer incidence rates in California declined significantly compared with stable incidence rates for the combined SEER area of five states and three metropolitan areas.
JAMA Pediatrics
Authors: Phil Fontanarosa, Annette Flanagin, Brenda Gregoline, Tracy Frey, Shannon Sparenga, Miriam Cintron, Paul Ruich, Diane Cannon, Connie Manno, Fred Marshall, Laura Copyreaders, Catherine Adamcyzk, Jan Alden, Mary Clavey, Gillian Coerver-Connolly, Laura Dickens, Juliann King, Donna Tarsney, Caroline Thordsen, Wanda Assistant, Larry Bryant, Monica Mungle, Elaine Williams, Lenette Gardner-Gullens, Fanny Brown, Paul Frank, Rachell Lozano, Michaela Mark, Kathryn Muskovich, J Neff, Kate Pezalla, Gale Saulsberry, Michael Berkwits, Michelle Kurzynski, Eric Butkus, Christopher Hastings, Craig Mccaffrey, Reuben Rios, Ronna Henry, Staff Bird, Alison Burke, Cassio Lynm, David Song, Deputy Livingston, Thomas Cole, Marla Hall, Deanna Willis, Yolanda Davis, Joseph Thornton, Deanna Bellandi, Jim Periodical, Thomas Staff, Monica Smith, Jeffery Bonistalli Manager, Kathy Staff, Mirna Monal, Tim Melroy, Thalia Moss, Tem Harrier, Susan Henning, Mark Thornbury, Tricia Castellano, Saskia Bolore, Gretchen Linder, Brian Mccartney, Rebecca Haas, Christine Hearne, Irma Lara, Audra Lawlor, Scott Marketing, Matt Herron, Elizabeth Solaro, Geoffrey Flick, Paul Gee Managers, Rick Bell, Michael Mcgraw, Sara Nagy, Stacy Staff, Millette Jackson-Bates, Karen Adams-Taylor, Karl Elvin, Sue Sherrill, Brian Shields Managers, David Antos, Chris Borden, Debbie Camp, Lydia Cruz, Diane Darnell, Colleen Kelly, Chris Meyer, Jaye Mize, Annemarie Neff, Sean O'donnell, Sean Ohlson, Phil O'leary, Ryan Patella, Susan Price, Denise Steinhauser, Production Services, Kim Boler, Rhonda Brown, Timothy Burke, Daniel Degroot, Jordynn Farrar, Euwanaha Joiner-Smith, Cindy Rendlen, Ellen Yoshihara, Circulation Services, Julie Burton, Dexter Golden, Erin Hinchcliff, Noemi Rivera, Geneine Van, Someren Composition, New Media, Gail Barrett, Regina Brownlee, Brenda Chandler-Grayer, Scott Curl, Amy Evers, Teri Hutchison, Mary Kuranda, Joshua Lampinen, Patricia Panek, La Son, Diggs Sledge, George Thomson Graphics, Joe Amft, Maria Duda, Fred Furtner, Carolyn Hall, Maria Kowalkowski, Proofreading Carol, Joy Farrell, Daniel James, Judith Literskis, Teresa Omiotek, James Madara, Bernard Hengesbaugh, Dimitri Christakis, Washington Joffe, Ron Keren, Suzanne Shuey, Benjamin French, Peter Cummings, Samir Shah, Howard Bauchner, Frederick Rivara, Matthew Davis, Ann Arbor, Cherrie Boyer, San Francisco, Robert Bradley, Maria Britto, John Campo, Aaron Carroll, Indiana Frank, Joseph Chaloupka, Mitchell Cohen, Chris Feudtner, Kathleen Janz, Iowa City, Terry Klassen, Joyce Lee, Michigan Michelle, Huckaby Lewis, Maryland Saiman, New York, York Samir, Martha Sola-Visner, Jean-Claude Carel, Shabir Madhi, Ben Marais, Frank Oberklaid, Susan Sawyer, Joan-Carles Surís
Journal: JAMA Pediatrics (2014)
Erratum to “Sustained Phenotypic Correction of Hemophilia A Mice Following Oncoretroviral-Mediated Expression of a Bioengineered Human Factor VIII Gene in Long-Term Hematopoietic Repopulating Cells”
Authors: Morvarid Moayer, Ali Ramezani, Richard A. Morgan, Teresa S. Hawley, Robert G. Hawley
Journal: Molecular Therapy (2005)

The publisher regrets that the column headings in Table 1 on page 897 were transposed during the final typesetting of the article after approval of the proofs. In addition, footnote d was omitted. The corrected Table 1 appears below.TABLE 1Phenotypic correction of hemophilia A miceMouseNo. cells transplantedWeeks posttransplant% EGFP-positive cellsaPercentage of mononuclear cells expressing EGFP in peripheral blood, BM, and spleen determined by flow cytometric analysis at time of tail clipping or sacrifice.Factor VIIIbMean ± SD (from triplicate determinations). (mIU/ml)SurvivalcAll MSGV-sfVIIIΔB-IRES-EGFP BM transplant recipients evaluated survived tail clipping (+) as did C57BL/6 mice, whereas naïve E-16−/−/B7-2−/− mice died within 2–12 h.Peripheral bloodBMSpleenPrimary recipients22 × 1061512.59.6NDdND, not determined.NDND32 × 106157.214.5NDNDND42 × 1061519.339NDNDND62 × 106216.54.74.9102 ± 16+72 × 1062232.222.4ND85 ± 19+82 × 1062110.97.35.7<10+92 × 106217.814.95.3141 ± 63+102 × 1062116.320.4ND259 ± 75+112 × 106229.27.4ND297 ± 70+163.5 × 106205.47.85.4109 ± 19+173.5 × 106205.5ND3.539 ± 13+183.5 × 106202.61.31.6<10+193.5 × 1062132.629ND505 ± 42+203.5 × 106218.48.9ND125 ± 28+213.5 × 1062113.411.3ND96 ± 28+Secondary recipients2–11.8 × 107197.22.33.4<10+2–21 × 107198.12.32.5<10+4–11 × 1071910.96.16190 ± 30+4–21 × 1071916.53.23.565 ± 25+ControlsE-16−/−/B7-2−/−<10 0/4C57BL/6680 ± 140 4/4a Percentage of mononuclear cells expressing EGFP in peripheral blood, BM, and spleen determined by flow cytometric analysis at time of tail clipping or sacrifice.b Mean ± SD (from triplicate determinations).c All MSGV-sfVIIIΔB-IRES-EGFP BM transplant recipients evaluated survived tail clipping (+) as did C57BL/6 mice, whereas naïve E-16−/−/B7-2−/− mice died within 2–12 h.d ND, not determined. Open table in a new tab Sustained phenotypic correction of hemophilia a mice following oncoretroviral-mediated expression of a bioengineered human factor VIII gene in long-term hematopoietic repopulating cellsMoayeri et al.Molecular TherapyNovember, 2004In BriefHematopoietic stem cells (HSCs) are an attractive target cell population for hemophilia A gene therapy because of their capacity to regenerate the hematolymphoid system permanently following transplantation. Here we transplanted bone marrow (BM) cells transduced with a splicing-optimized MSCV oncoretroviral vector expressing a secretion-improved human factor VIII gene into immunocompromised hemophilic mice that had received a reduced dose conditioning regimen. An enhanced green fluorescent protein (EGFP) reporter gene linked to an encephalomyocarditis virus internal ribosome entry site was incorporated into the vector to allow preselection of transduced cells and facile evaluation of engraftment. Full-Text PDF Open Archive
Rhabdomyolysis and acute renal failure in sickle cell anaemia
Authors: S M Knowles, S Devereux
Journal: BMJ (1985)

Rhabdomyolysis and acute renal failure in sickle cell anaemiaAcute renal failure due to striated muscle necrosis is well recognised in a wide range of conditions.'This report concerns a patient with homozygous sickle cell disease, in whom acute renal failure was associa- ted with rhabdomyolysis during a severe sickling episode.
General Surgery.
Journal: JAMA (1910)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CAN THE RED CROSS SURVIVE?
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Thrombectomy Suggested for Venous Occlusion
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Innovative procedures for micro-elimination of HCV infection in a high-risk population of undocumented migrants and low-income refugees
Authors: Lorenzo Onorato, Nicola Coppola, Loredana Alessio, Stefania de Pascalis, Vincenzo Messina, Caterina Sagnelli, Evangelista Sagnelli, Giovanni Di Caprio, Margherita Macera, Mariantonietta Pisaturo
Journal: Journal of Hepatology (2020)
In Brief
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Drug Resistance in Chinese Hamster Ovary Cells During Recovery From Severe Hypoxia
Authors: R. E. WILSON, P. C. KENG, R. M. SUTHERLAND
Journal: JNCI Journal of the National Cancer Institute (1990)

Table 1.Distribution of the genotypes and alleles of the L-myc gene among normal individuals, gastric cancer patients, and breast cancer patients No. of genotypes No. of alleles (frequency) Normal Gastric cancer Meta(-) Meta(+) Breast cancer Meta(-) Meta(+) * Significantly higher in the patients with metastasis than in those without metastasis.need to be done on a variety of cancers.This kind of analysis may also lead to elucidation of genetic mechanisms of metastatic potential.However, at present, for the patients with tumors such as gastric cancer, lung cancer, or renal cancer, the analysis of the L-myc genotype may be useful in predicting the possibility of metastasis.
The Ophthalmic Formulary
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prostatic Carcinoma
Authors: Lester A. Klein
Journal: New England Journal of Medicine (1979)

EACH year there are 42,000 new cases of prostatic carcinoma in the United States,1 and with 17,000 deaths per year, it is the second leading cause of cancer deaths among American men.2 Despite these alarming statistics, it can be calculated that 30 per cent, or roughly 12,000, of the new cases are potentially curable when first discovered.* But it seems that treatment designed to cure patients of this disease is being provided to only a fraction of the potentially curable ones. Consider that one of the most active groups in the country engaged in urologic surgery and oncology attempts cure . . .
Renal vein ligation
Authors: D. A. DeLaurentis
Journal: JAMA (1970)

<h3>To the Editor.—</h3> The letter from Drs Jennings and Glucksman (<b>213</b>: 1905, 1970) introduced a case demonstrating that renal vein ligation, unlike thrombosis, was without deleterious effect. They could find no report of this fact. Nevertheless there are a number of references to division of the left renal vein in man. First described by Erlik et al<sup>1</sup>in 1964, they and others<sup>2-4</sup>later have presented a series of cirrhotic individuals in whom the vena caval stump was used for portarenal anastomosis with no detectable harm to the kidney. Three years ago Gonzalez et al<sup>5</sup>reported inThe Journalthat, during removal of a pheochromocytoma, they ligated the left renal vein of their patient without permanent sequelae. About the same time, Neal and Shearburn<sup>6</sup>recommended division of the left renal vein as an adjunct to resection of abdominal aortic aneurysm, having performed this maneuver in 11 patients.