tbuckley/cabot-search huggingface dataset:
“Pseudodoxia Pediatrica”
Journal: JAMA (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TCT-13 Ten-Year Follow-Up After Revascularization in Elderly Patients With Complex Coronary Artery Disease
Authors: Masafumi Ono, Patrick Serruys, Hironori Hara, Hideyuki Kawashima, Chao Gao, Rutao Wang, Kuniaki Takahashi, Neil O'Leary, Scot Garg, Michael Mack, David Holmes, Marie-Claude Morice, Pieter Kappetein, Daniel Thuijs, Thilo Noack, Piroze Davierwala, Friedrich-Wilhelm Mohr, Yoshinobu Onuma
Journal: Journal of the American College of Cardiology (2021)
Narcolepsy
Authors: Jane F. Desforges, Michael S. Aldrich
Journal: New England Journal of Medicine (1990)

NARCOLEPSY, a syndrome of excessive sleepiness and abnormalities of rapid-eye-movement (REM) sleep,1 is a distinct neurologic disorder with characteristic clinical symptoms and sleep-laboratory findings. Narcolepsy associated with cataplexy is often called "classic narcolepsy." There have been several important advances in understanding narcolepsy since the last review in the Journal.2 Narcolepsy is strongly linked to certain Class II HLA antigens, indicating the presence of a "narcolepsy-susceptibility" gene on chromosome 6. Pharmacologic and pathological studies of human and canine narcolepsy have demonstrated abnormalities of monoaminergic and cholinergic functioning in the brain. The objective assessment of sleepiness and the onset of REM . . .
Involutional Osteoporosis
Authors: K Kaneda, M Kokaji
Journal: New England Journal of Medicine (1987)

Involutional osteoporosis has been divided into two types. Type-1 osteoporosis, known as postmenopausal osteoporosis, occurs in women after menopause. Type-2 osteoporosis, known as senile osteoporosis, occurs in men and women over 70 years of age. The general symptoms are back pain in patients with Type-1 osteoporosis and back pain with spinal deformity in Type-2. Vertebral fractures occur in Type-1 and fractures of the femoral neck are common in Type-2. Post-traumatic vertebral collapse following compression fractures is recently recognized as one of the important and serious complications in osteoporotic fractures. Other fractures such as femoral neck, wrist (distal radius) and proximal humerus are common in this disease. Study of bone metabolism and its pharmaceutical reaction has advanced, but the treatment of osteoporosis is still not satisfactory.
Book Listings
Journal: Annals of Internal Medicine (2001)

Book Listings16 January 2001Book ListingsSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-134-2-200101160-00002 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail CardiologyBasic Electrocardiography in Ten DaysDR Ferry. 266 pages. New York: McGraw-Hill; 2001. $40.00. ISBN 0071352929. Order phone 800-262-4729.Cardiac Pacing and Defibrillation: A Clinical ApproachDL Hayes, MA Lloyd, and PA Friedman. 600 pages. Armonk, NY: Futura; 2000. $89.00. ISBN 087993462X. Order phone 800-877-8761.Cardiovascular Medicine2nd edition. JT Willerson and JN Cohn, eds. 2344 pages. Philadelphia: WB Saunders; 2000. $165.00. ISBN 0443070008. Order phone 800-545-2522.Dispersion of Ventricular Repolarization: State of the ArtSB Olsson, JP Amlie, and S Yuan, eds. 330 pages. Armonk, NY: Futura; 2000. $125.00. ISBN 0879934581. Order phone 800-877-8761.Handbook of Contrast Echocardiography: Left Ventricular Function and ... Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 16 January 2001Volume 134, Issue 2Page: B1KeywordsBurnsHealth information technologyPrevention, policy, and public health ePublished: 16 January 2001 Issue Published: 16 January 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
A Kinetic Study on Functional Impairment of Nitric Oxide-Exposed Rat Erythrocytes
Authors: Nobuji Maeda, Kazuhiko Imaizumi, Kazunori Kon, Takeshi Shiga
Journal: Environmental Health Perspectives (1987)

In acute in vivo exposure of rats to 25 to 250 ppm nitric oxide (NO) by use of a small exposure chamber for a single rat, the kinetic parameters of nitrosylhemoglobin (Hb-NO) and methemoglobin (MetHb) formation were estimated (with the aid of computer simulation) on the basis of experimental data. The biochemical and rheological injuries of erythrocytes were also examined. The time course of Hb-NO and MetHb formation in blood was compared with that simulated by a simplified kinetic model. The rate of MetHb formation from Hb-NO was much faster than MetHb reduction to ferrous form and dissociation of Hb-NO; thus, MetHb content was always greater than Hb-NO content. The activity of MetHb reduction decreased on exposure to a high concentration of NO, but the activity was recovered when rats were placed in clean air. Rheologically, the blood viscosity was scarcely altered, but a few undeformed cells were detected at high shear stress. Morphologically, echinocytic transformation was observed to some extent. Biochemically, the crosslinking of membrane proteins and the alteration of acyl chain composition of membrane phospholipids were not detected in the in vivo exposure, though the in vitro exposure of rat erythrocytes to high concentrations of NO revealed remarkable oxidative crosslinking among membrane proteins and hemoglobin. In conclusion, both for persistent methemoglobinemia and for membrane damage, the maintenance of reductive activity in erythrocytes is the most important determinant factor for the protection of NO-induced oxidative injury.
International Symposium on Xeroderma Pigmentosum and other Nucleotide Excision Repair Disorders Downing College, University of Cambridge, Cambridge, UK. 20–22 March 2019
Authors: A. Chikhaoui, I. Krawa, N. Calmels, C. Obringer, Sahar Elouej, Annachiara de Sandre-Giovannoli, Nicolas Levy, M. Zghal, M. Ricchetti, V. Laugel, I. Turki, S. Abdelhak, H. Yacoub-Youssef
Journal: British Journal of Dermatology (2019)
Practical Clinical Chemistry: A Guide for Technicians.
Journal: JAMA (1953)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diabetes, New York
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Gonococcal Tenosynovitis-Dermatitis and Septic Arthritis
Authors: Alfonse T. Masi
Journal: JAMA (1981)

<h3>To the Editor.—</h3> Regarding the recent report of Thompson et al (1980; 244:1101) describing a randomized trial of either aqueous crystalline penicillin G potassium, 1 megaunit every eight hours intravenously (IV) (total dosage, 8 million units/day) for three days, or erythromycin stearate or estolate, 0.5 g every six hours for five days, in the treatment of gonococcal tenosynovitis or arthritis, a statement was made that no previous controlled therapy study of these common syndromes had been found. The authors had failed to note in their review of publications on the treatment of these conditions a double-blind randomized trial that had appeared several years earlier inThe Journal(1976;236:2410). Trentham et al tested whether high-dose penicillin G potassium was necessary for the treatment of gonococcal arthritis. In that study, all patients received 600,000 units of aqueous penicillin G procaine intramuscularly every 12 hours for up to ten days and either 10
<i>The Shattuck Lecture—1891—Neurasthenia and Its Mental Symptoms</i>. By Edward Cowles, M. D., LL. D., etc. Read before the Massachusetts Medical Society, June 9th, 1891. Boston: David Clapp &amp; Sons, 1891
Authors: H. S. W.
Journal: American Journal of Psychiatry (1892)

tion in the subjective nature of hallucinations might prevent the genesis of delusions and the necessity of commitment to a hospital, except in the degenerative psychoses, where permanent benefit is not to be expected.
Africa’s Ongoing Fight Against Polio
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ESPAC-3(v2): A multicenter, international, open-label, randomized, controlled phase III trial of adjuvant 5-fluorouracil/folinic acid (5-FU/FA) versus gemcitabine (GEM) in patients with resected pancreatic ductal adenocarcinoma
Authors: J. Neoptolemos, M. Büchler, D. D. Stocken, P. Ghaneh, D. Smith, C. Bassi, M. Moore, D. Cunningham, C. Dervenis, D. Goldstein
Journal: Journal of Clinical Oncology (2009)

LBA4505 Background: Adjuvant 5-FU/FA (ESPAC-1 trial) and GEM (CONKO-001 trial) provide improved survival for patients with resected pancreatic cancer compared to no chemotherapy. The aim of the ESPAC-3 (v2) trial was to compare 5FU/FA vs GEM to identify if either adjuvant chemotherapy was associated with a significantly better survival. Methods: Patients with an R0/R1 resection for pancreatic ductal adenocarcinoma were randomized (stratified for resection margin status and country) <8 weeks of surgery to receive either 5FU/FA (FA, 20 mg/m2, iv bolus injection followed by 5-FU, 425 mg/m2, iv bolus injection given 1–5d every 28 days) or GEM (1,000mg/m2 iv infusion 1d, 8d and 15d every 4 weeks) for 6 months. The primary outcome measure was overall survival; the secondary measures were toxicity, progression free survival and quality of life. 1,030 patients were needed to detect a 10% difference in 2-year survival rates with 90% power. Results: 1,088 patients from 16 countries were randomized from July 2000 to Jan 2007 (5FU/FA = 551, GEM = 537). Median (range) age was 63 (31–85) years; 598 (55%) were men. Median tumor size was 30 (20–350) mm; 384 (35%) were R1 resections; 777 (72%) were node positive; and 263 (25%) were poorly differentiated tumors. Final analysis was carried out on an intention to treat basis with a minimum of 2 years follow-up after 753 (69%) patients had died. Median (IQR) follow-up of 335 alive patients was 34.2 (27.1–43.4) months, equal across treatment groups. Median survival from resection of patients treated with 5FU/FA was 23.0 (95% CI: 21.1, 25.0) months and for patients treated with GEM this was 23.6 (95%CI: 21.4, 26.4) months. Log-rank analysis revealed no statistically significant difference in survival estimates between the treatment groups (c2LR=0.7, p=0.39, HRGEM=0.94 (95%CI: 0.81, 1.08)). There was no significant difference in the effect of treatment across subgroups according to R status (test of heterogeneity c21=0.3, p=0.56). Conclusions: This is the largest adjuvant trial ever conducted for pancreatic ductal adenocarcinoma and showed no significant difference in survival between adjuvant 5FU/FA and adjuvant GEM. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Pfizer Cytimmune, Oxford Biomedica, Pharmexa
Molecular Alterations Critical to the Development of Arteriosclerotic Plaques: A Role for Environmental Agents
Authors: Arthur Penn
Journal: Environmental Health Perspectives (1989)

Cardiovascular disease (CVD) is the single greatest cause of death in the United States and in Western Europe. There is strong epidemiologic evidence for an interaction of environmental and genetic factors in the development of clinically significant episodes of CVD. However, the specific contributions of each of these components to the onset and development of CVD remain unclear. According to the monoclonal hypothesis, arteriosclerotic plaques, the principal lesions associated with CVD, are monoclonal in origin and can be considered benign smooth muscle cells tumors of the artery wall. It follows that somatic cell alterations, possibly brought about by chemical mutagens or viruses, may play critical roles in plaque formation. During the past decade, evidence has been presented from a number of laboratories, including ours, that in animal model systems, both viruses and chemical carcinogens can play a role in the appearance and development of arteriosclerotic plaques. We have recently provided evidence consistent with the view that somatic cell alterations are critical to plaque development in man: DNA from human arteriosclerotic plaques. transforms cells in vitro and injection of these transformed cells into nude mice results in tumor formation. Thus, plaque DNA behaves similarly to tumor DNA under defined assay conditions.
UNTOWARD EFFECTS FROM THE SALICYLATE OF SODIUM.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Neurology for the Non-Neurologist
Authors: Stanford Wessler
Journal: JAMA (1989)

This slim paperback contains 25 topical chapters on selected subjects in neurology of interest to medical students, physicians-in-training, and primary care clinicians. Although, as the editors suggest, this book by 30 contributors can be read from cover to cover, it would be more prudent to examine a chapter at a time as it pertains to a current clinical patient. With either approach, the book is useful. In essentially every chapter, there is a practicality complemented by a conscious effort not to oversimplify that clearly deserves praise. This is particularly well illustrated by chapter 5 on cerebral vascular disease, in which 15 pages accurately summarize the state of the art of this contentious topic, and in which the figures and tables complement rather than usurp the text. The various chapters are meant to be read through and are written by teachers who give evidence of a rich prior experience in the
Participant Index
Authors: Coleman Oj, Del Ma, Egglemn Hc, Arrindell El, Coleman Sc, Del Piero, Eilerman Ra, Aaberg Tm, Arteriber1 )'jf231 Benech, Brod Rd204, Cas1ejon Ma, Colenbrender 183, Del Lv, E~rig Abbottrl, Bennett Sr, Brodell Lp, Abboud Eb, Asbell Pa66, Caswellg87 Coleswh185, Della Rocca, R 231, Maghraby Ma, E Sayyad, Abelson Mb, Asrani Sg, Berger As, Brodsky Mc, Ei-Maghraby Ma, Abrams Gw, Assil Kk, Condes Vs, Atwood Jd61, Berman Moo, Brown Dc, Auy-K1b3 Berrocal, Augsburger Jj, Berson El, Cooksey Jc, Derespinis Pa, Berson Fg, Brown Hs, Derse 108 Ellisjrg, Augustine Rj, Bertschy Ma, Brown Ks, Ellsworth Rm, Adams Augusto, Bettman Sr, Brown Sj, Char Dh, Elsas Dhaliwalr98, Cowan Chaudhl)'n73, Engstrom Re, Aiello Lp, Bu\jarelli Dm, Epstein Ga, Ainbinder Oj, Airaksinen Pj, Baoon As, Blackman Hj, Dipilioma85 Erickson, Aitken Pa207, Bedrinath Ss, Blankenship Gw, Burde Rm, Erzurum Dobsonmv77, Aizuss Dh, Blaydes Je, Burgess Db, Chen M66, Crawtord Jb, Essepian Jp, Akar Ab226 Baerveldt, Blecher Mh, Burkdw67 Chen, Burkll67 Chen, Plio Crowe, Cuitecl06 Dolan Bj, Evans Rb235, Albert Dm, Bunewja92 Cheng, Culbertson Ww, Donnenfeld Ed, Milo Blum, Chewey120 Cunningham Fill, Alexendrakis 83 Balokem, Blumenkranz Ms, Busse Bj, Cuppies Hp, Alfaro Dv73, Balyeat Hd, Busse 119 Chewsj, Cumyn Km, Donshik Pc, Dahlhauser Kf, Dubord Pj, Feill M230, Amatopai49 Bartleygb, Bouchard Cs, Christy Ne, Cacioppo Lr, Chu Fc, Dailey Ra, Dugel Pu, Feldman F81, Ba1eman Jb, Boume Wm, Chuang El, Duker Js, Feldman Rm, Anderson Dr, Batlle Jf, Bowman Cb, Chumant130 Danielsm, Feldman Andersonja, Baudouin 136 Boyle, Cambie Ej, Dulaney Dd, Feldman St, Anderson Rl, Baum Jl, Camesasca Chylack, Campbell Cv, Cibisgw220 Danzwa, Andrassy Kilo, Baylis Hi, Campbell Dg, Dunn Felixjs, Durcan Datilesmb70, Fellenbaum Ps, Angrist Rc, Beaton Bradyj, Campbell Rc, Civantos Jm, Applega1e Kk, I Bechert, Clayman Hm, Dawson Cr, Ferguson Ob, Beck Ad, Brauns1ein Ra, Aquino Nm, Blliauxb229 Capone, Bredvik Caprioli, Edmond Jc, Finger Pt, Arnold Ac, Belin Mw, Brine Bj, Carroll Rp, Cohen Kl206, De Sousa, Edwards Rp, Arnold Pn, Brinser Jj67, Carterjc213 Cohen, De Vivero, Bell Dw147, Brint Sf, Cohen Sm, Dehaven Cr, Egan Km, Bell Fc205, Brinton Da, Deichman Cb, Finkels1ein Em, Arnoldi Ka, Bellows Ar, Brinton Gs, Casebeer Jc, Cole Iii Hp, Deitz Mr, Egbert Pr, Knolle Jrge, Lambert Rw, Foster Gibson, Hurvitz Lm, Herbert Cp, Hutchinson Ak, Karcioglu Za, Gifford Rw, Hemandez -Quintela, Hyde Ll, Lane L83, Frank Rn, Gilbert Ws, Guarisco 125 Herschler, Hyman Bn, Kartin Db, Lane Ss, ! Kl, Franklin Rm, Hersey Jm, Hyndiuk Ra, Karp Ow, Fransen Sr, Guptakl82 Hersh, Karp Ej, Frantzjm Kl, Gilman Jp, Hersh Ps, Kokame Gt73, Lanigan Lp, Gilmore Je, Gutman Fa, Kolker Ae, Guy Jr, Ibanez He, Kassar Bs, Kastl Pr, Lau-Sickon Lk, Hess Oj, Kong Yt, Lauer Sa, Ginsburg Lh, G Gonnering, Hodge Do, Jampol Lm, Kelman Cd, Javate Rm, Kelsey Sf, Lee S237, Gager We, Goodwin Ja, Hoffman Rs71, Javitt Jc, Krugere83 Lee, Gagliano Da, Hannig 151 Holcomb
Journal: Ophthalmology (1993)