tbuckley/cabot-search huggingface dataset:
Intravascular ultrasound guided direct stenting without predilatation in native coronary arteries: Procedural results and late clinical outcomes Javed M. Ahmed, Augusto D. Pichard, Lowell F. Satler, Gary S. Mintz, John R. Laird, Ron Waksman, Kenneth M. Kent. Washington Hospital Center, Washington, DC
Journal: Journal of the American College of Cardiology (2001)
The Social Responsibilities of Modern Medicine
Journal: JAMA (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Review: Adjunctive corticosteroids reduce mortality and clinical failure in adult inpatients with CAP
Authors: Benton R. Hunter
Journal: Annals of Internal Medicine (2018)

ACP Journal Club17 April 2018Review: Adjunctive corticosteroids reduce mortality and clinical failure in adult inpatients with CAPBenton R. Hunter, MDBenton R. Hunter, MDIndiana University School of Medicine, Indianapolis, Indiana, USA (B.R.H.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/ACPJC-2018-168-8-040 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationStern A, Skalsky K, Avni T, et al. Corticosteroids for pneumonia. Cochrane Database Syst Rev. 2017;12:CD007720. https://pubmed.ncbi.nlm.nih.gov/29236286Clinical Impact RatingsGIM/FP/GP: Emergency Med: Hospitalists: Critical Care: Pulmonology: References1 Sadeghirad B, Siemieniuk RAC, Brignardello-Petersen R, et al. Corticosteroids for treatment of sore throat: systematic review and meta-analysis of randomized trials. BMJ. 2017;358:j3887. [PMID: 28931508] Google Scholar2 Goldberg H, Firtch W, Tyburski M, et al. Oral steroids for acute radiculopathy due to a herniated lumbar disk: a randomized clinical trial. JAMA. 2015;313:1915-23. [PMID: 25988461] Google Scholar3 Walters JA, Tan DJ, White CJ, et al. Systemic corticosteroids for acute exacerbations of chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2014;9:CD001288. [PMID: 25178099] Google Scholar Author, Article, and Disclosure InformationAffiliations: Indiana University School of Medicine, Indianapolis, Indiana, USA (B.R.H.)This article was published at Annals.org on 3 April 2018. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoReview: Adjunctive corticosteroids do not reduce mortality or clinical failure in adult inpatients with CAP Benton R. Hunter Review: Adjunctive corticosteroids do not reduce mortality or clinical failure in adult inpatients with CAP Benton R. Hunter Metrics 17 April 2018Volume 168, Issue 8Page: JC40KeywordsAntibioticsChildrenInpatientsIntensive care unitsMorbidityMortalityPneumoniaRelative riskShockSteroids ePublished: 17 April 2018 Issue Published: 17 April 2018 Copyright & PermissionsCopyright © 2018 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Book Listings
Journal: Annals of Internal Medicine (2002)

Book Listings6 August 2002Book ListingsSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-137-3-200208060-00028 SectionsAboutFull Text ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail CardiologyAlcohol and Heart DiseaseR Watson and AK Myers, eds. 261 pages. Philadelphia: Taylor & Francis; 2002. $80.00. ISBN 0415273471. Order phone 800-821-8312.Beta-Blockers in Heart FailureJ McMurray and MJ Kendall. 108 pages. Philadelphia: Taylor & Francis; 2002. $15.00. ISBN 1853179027. Order phone 800-821-8312.Blackwell's Primary Care Essentials: CardiologyJ Sutherland. 304 pages. Cambridge, MA: Blackwell Science; 2001. $40.00. ISBN 0632044756. Order phone 800-759-6102.Cardiac Arrythmias: Practical Notes on Interpretation and Treatment6th edition. DH Bennett. 340 pages. Boston: Arnold; 2002. $30.00. ISBN 0340807318. Order phone 800-759-6102.Cardiogenic Shock: Diagnosis and TreatmentD Hasdai, PB Berger, A Battler, and DR Holmes Jr, eds. ... Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 6 August 2002Volume 137, Issue 3Page: B1 ePublished: 6 August 2002 Issue Published: 6 August 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.Loading ...
Danazol
Authors: ROBERT L. BARBIERI
Journal: Annals of Internal Medicine (1982)

Letters and Corrections1 August 1982DanazolROBERT L. BARBIERI, M.D.ROBERT L. BARBIERI, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-97-2-286_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The recent review of danazol by Madanes and Farber (1) is an excellent summary of the drug's properties. However, there are a few substantive errors that need correction.Madanes and Farber state than danazol inhibits adrenal 16α-hydroxylase. The paper (2) they cite to support this statement does not examine the effects of danazol on 16α-hydroxylase, and other unpublished reports have shown that danazol does not inhibit 16α-hydyroxylase. The authors state that danazol inhibits microsomal and mitochondrial cytochrome P-450 in cultured adrenal tissue. In fact, the experiments cited were done on isolated mitochondrial and microsomal fractions in vitro...References1. MADANESFARBER AM. Danazol. Ann Intern Med. 1982;96:625-30. LinkGoogle Scholar2. BARBIERIOSATHANONDHCANICKSTILLMANRYAN RRJRK. Danazol inhibits human adrenal 21- and 11-hydroxylation in vitro. Steroids. 1980;35:251-63. CrossrefMedlineGoogle Scholar3. HENDERSENTSANG KB. Danazol suppresses luteal function in vitro and in vivo. Fertil Steril. 1980;33:550-6. CrossrefMedlineGoogle Scholar4. BARBIERIRYAN RK. Danazol: endocrine pharmacology and therapeutic applications. Am J Obstet Gynecol. 1981;141:453-63. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Massachusetts General Hospital Boston, MA 02114 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAdditive hormonal therapy in women with advanced breast cancer 1 August 1982Volume 97, Issue 2Page: 286-286KeywordsDrugs Issue Published: 1 August 1982 PDF DownloadLoading ...
Measles immunization: recommendations, challenges, and more information
Authors: G. Peter
Journal: JAMA (1991)

Generic recommendations for childhood immunization include guidelines for administration of vaccine to infants and children with febrile and minor illnesses. The most recent recommendations issued by the Immunization Practices Advisory Committee (ACIP) of the US Public Health Service state that "minor illnesses such as mild upper respiratory infections (URI) with or without low-grade fever are not contraindications for vaccination."<sup>1</sup>The ACIP further notes the importance of taking every opportunity to provide age-appropriate vaccinations, particularly "in persons whose compliance with medical care cannot be assured." The American Academy of Pediatrics gives similar recommendations.<sup>2</sup> Mild acute illness in some circumstances has been inappropriately considered a contraindication to vaccination. This misconception has contributed to missed opportunities to give measles vaccine to children who subsequently developed measles.<sup>3</sup>This and other missed opportunities to vaccinate children against measles at the recommended age have been incriminated as important factors in the occurrence of
Pregnancy Outcomes in Women with Aplastic Anemia Treated with Immunosuppression
Journal: Annals of Internal Medicine (2002)

Summaries for Patients6 August 2002Pregnancy Outcomes in Women with Aplastic Anemia Treated with ImmunosuppressionSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-137-3-200208060-00004 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Aplastic anemia is a failure of the bone marrow to make new blood cells of all types. Patients with aplastic anemia have too few red blood cells, white blood cells, and platelets. In addition to the problem of anemia, patients with aplastic anemia can have problems fighting infection and bleeding problems. Most patients who cannot be treated with bone marrow transplantation receive treatment with drugs that suppress the immune system. Aplastic anemia can develop during pregnancy and sometimes improves without treatment after pregnancy. Another situation is that women ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Outcome of Pregnancy and Disease Course among Women with Aplastic Anemia Treated with Immunosuppression.” It is in the 6 August 2002 issue of Annals of Internal Medicine (volume 137, pages 164-172). The authors are A Tichelli, G Socié, J Marsh, R Barge, N Frickhofen, S McCann, A Bacigalupo, J Hows, P Marin, D Nachbaur, A Symeonidis, J Passweg, and H Schrezenmeier, for the European Group for Blood and Marrow Transplantation Severe Aplastic Anaemia Working Party.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoOutcome of Pregnancy and Disease Course among Women with Aplastic Anemia Treated with Immunosuppression André Tichelli , Gérard Socié , Judith Marsh , Renée Barge , Norbert Frickhofen , Shaun McCann , Andrea Bacigalupo , Jill Hows , Pedro Marin , David Nachbaur , Argiris Symeonidis , Jakob Passweg , Hubert Schrezenmeier , and Metrics 6 August 2002Volume 137, Issue 3Page: I-34KeywordsAplastic anemiaBirthBone marrowDrugsImmunosuppressivesPregnancyStrokeTransplantationTwinsWhite blood cells ePublished: 6 August 2002 Issue Published: 6 August 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Atlas of Traumatic Fractures and Luxations.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Maximum urine concentrating ability in children with Hb SC disease: Effects of hydroxyurea
Authors: Rathi Iyer, Radhakrishna Baliga, Ronald L. Nagel, Carlo Brugnara, Kent Kirchner, Shirley Hogan, Martin H. Steinberg
Journal: American Journal of Hematology (2000)

Studies in adults with Hb SC disease suggested that hydroxyurea reduced hemolysis and increased red cell hydration. Because increased hydration should diminish the polymerization tendency of Hb S we hypothesized that hydroxyurea might repair the urine concentration defect of HbSC disease. Eight Hb SC disease patients, aged 10 to 17 years, were given hydroxyurea daily. Maximal urine concentrating ability following overnight fasting and after subcutaneous arginine vasopressin (dDAVP), blood counts, and cell volumes were observed for 12–15 months. All patients had impaired urine concentrating ability prior to hydroxyurea treatment and failed to increase their ability to concentrate urine following treatment (maximum urine concentration after an overnight fast and dDAVP, 520–530 mOsm). Mean corpuscular volume (MCV) and reticulocyte MCV increased after administration of hydroxyurea, and the reticulocyte count and ratio of red cell hemoglobin to reticulocyte hemoglobin fell but there was little change in PCV. Hb F increased substantially in 2 patients but showed little change in the remaining patients. There was no evidence that hydroxyurea was associated with increased urine concentrating ability in children with Hb SC disease. These results may reflect irreversible renal medullary damage prior to beginning treatment or insufficient intensity or duration of treatment. Am. J. Hematol. 64:47–52, 2000. © 2000 Wiley-Liss, Inc.
Decreased ureagenesis from alanine, but not from ammonia and glutamine, in the perfused rat liver after partial hepatectomy
Authors: M Moriyama
Journal: Hepatology (1996)

Ureagenesis from ammonia, alanine, and glutamine in the liver after partial hepatectomy (PH) was determined by using the liver-perfusion system. The maximum rate of ureagenesis from ammonium chloride (10 mmol/L) in hepatectomized (HX) rats at 24 hours after surgery was obtained in the presence of ornithine, lactate, and pyruvate, and it was almost identical to that in sham-operated (SO) rats. The rate of urea production from glutamine (1 mmol/L or 10 mmol/L) in HX rats was significantly lower than that of SO rats with a concomitant decrease in hepatic glutaminase activities. However, the rate of urea synthesis from glutamine (1 mmol/L) in the presence of added ammonia (0.5 mmol/L) was accelerated approximately 10-fold, and the significant difference in the rate of urea formation between HX and SO rats was abolished. This result indicates that there is enough glutaminase to generate ammonia from glutamine in the liver of HX rats. The rate of urea production from alanine (1 mmol/L or 10 mmol/L) in HX rats was significantly decreased at 24 hours following surgery, while that of SO rats was increased. The decreased formation of urea from alanine was not seen at 72 and 120 hours after the operation. These results suggest that during the proliferation phase of liver regeneration, a reduction of ureagenesis from alanine facilitates the remnant liver to make nonessential amino acids such as aspartate. This metabolic alteration might be related to the proliferation of liver cells.
Life Extension
Authors: Edward L. Schneider, John D. Reed
Journal: New England Journal of Medicine (1985)

Extension of the life span has become an increasingly prominent subject in the media. Vitamins, nutrient supplements, minerals, and skin creams have been aggressively promoted as being able to delay aging and prolong life. Books on longevity and life extension aimed at promoting such products have made several best-seller lists. A recent Congressional hearing on medical quackery devoted considerable time and effort to investigating anti-aging "cures."1 Unfortunately, there have been few attempts to examine the scientific basis for the claims of life extension made by promoters of such products.This article will examine several interventions that have been proposed to . . .
Grundriss der Augenheilkunde für Studierende und Praktische Aerzte.
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Landmine-Related Injuries, 1993-1996
Journal: JAMA (1997)

During 1980-1993, the incidence of landmine-related injuries doubled, resulting in an estimated 2000 deaths or injuries each month. Approximately 120 million landmines are buried in 71 countries throughout the world, and 2-5 million new landmines are planted each year. Some countries, such as Afghanistan, Angola, and Cambodia, have approximately 10 million landmines each. Landmines can have profound medical, environmental, and economic consequences, particularly for the civilian populations of those countries burdened with landmines. However, the consequences of landmines extend beyond the borders of those countries. Health-care workers and nongovernmental organizations are increasingly asked to assist emergency-affected, displaced, and refugee populations in regional conflicts, resulting in their increased exposure to landmines. This report describes three cases of landmine-related injury and illustrates the public health consequences of those injuries and the potential role for public health workers in preventing those injuries.
Quinidine
Authors: Andrew A. Grace, A. John Camm
Journal: New England Journal of Medicine (1998)

Quinidine is the most frequently prescribed antiarrhythmic drug,1 despite unease about its possible proarrhythmic actions. That caution is required with the use of quinidine was, however, recognized early. Although the beneficial effect of quinine on "rebellious palpitations" was described in the 18th century,2 it was noted almost from the outset that small doses of the more effective d-stereoisomer, quinidine, could occasionally result in dangerous idiosyncratic reactions.3 Initially used for cardioversion in patients with atrial fibrillation, quinidine was subsequently used widely as an antiarrhythmic drug, since it is less immunotoxic than procainamide and is without the anticholinergic, negatively inotropic actions . . .
Magnitude and functionality of HEV-specific CD8+ and CD4+ T cell responses in asymptomatic blood donors resemble those in acute and symptomatic patients
Authors: Janine Kemming, Benedikt Csernalabics, Marcus Panning, Markus Umhau, Robert Thimme, Tobias Böttler, Christoph Neumann-Haefelin
Journal: Journal of Hepatology (2020)
Megaloblastic Madness
Authors: A. D. M. Smith
Journal: BMJ (1960)

In response to the facilitating neurotransmitter serotonin (5-HT), the cAMP-dependent protein kinase (PKA) acquires a special mnemonic characteristic in Aplysia sensory neurons. PKA becomes persistently activated at basal cAMP concentrations owing to a decreased regulatory (R) to catalytic (C) subunit ratio. We previously implicated ubiquitin- mediated proteolysis in this selective loss of R. Here we show that ubiquitin (Ub), Ub-conjugates and proteasomes are present in cell bodies, axon, neuropil and nerve terminals of Aplysia neurons. Because R subunits are not decreased in muscle exposed to 5-HT, comparison of the two tissues provides a tractable approach to determine how the Ub pathway is regulated. We compared the structure of M1, the muscle- specific R isoform, to that of N4, a major neuronal R isoform, to rule out the possibility that the differences in their stability result from differences in structure. We present evidence that N4 and M1 are encoded by identical transcripts; they also behave similarly as protein substrates for the Ub pathway in extracts of the two tissues. Nervous tissue contains 20-times more free Ub, but we present evidence that the susceptibility of R subunits to degradation in neurons relative to muscle results from the greater capacity of neurons to degrade ubiquitinated proteins through the proteasome. Thus, factors that regulate the activity of proteasomes could underlie the enhanced degradation of R subunits in long-term sensitization.