tbuckley/cabot-search huggingface dataset:
Effect of Water Temperature on Dermal Exposure to Chloroform
Authors: Sydney M. Gordon, Lance A. Wallace, Patrick J. Callahan, Donald V. Kenny, Marielle C. Brinkman
Journal: Environmental Health Perspectives (1998)

We have developed and applied a new measurement methodology to investigate dermal absorption of chloroform while bathing. Ten subjects bathed in chlorinated water while breathing pure air through a face mask. Their exhaled breath was delivered to a glow discharge source/ion trap mass spectrometer for continuous real-time measurement of chloroform in the breath. This new method provides abundant data compared to previous discrete time-integrated breath sampling methods. The method is particularly well suited to studying dermal exposure because the full face mask eliminates exposure to contaminated air. Seven of the 10 subjects bathed in water at two or three different temperatures between 30 degrees C and 40 degrees C. Subjects at the highest temperatures exhaled about 30 times more chloroform than the same subjects at the lowest temperatures. This probably results from a decline in blood flow to the skin at the lower temperatures as the body seeks to conserve heat forcing the chloroform to diffuse over a much greater path length before encountering the blood. These results suggest that pharmacokinetic models need to employ temperature-dependent parameters. Two existing models predict quite different times of about 12 min and 29 min for chloroform flux through the stratum corneum to reach equilibrium. At 40 degrees C, the time for the flux to reach a near steady-state value is 6-9 min. Although uptake and decay processes involve several body compartments, the complicating effect of the stratum corneum lag time made it difficult to fit multiexponential curves to the data; however, a single-compartment model gave a satisfactory fit.
Origins of Medicine
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Slower fetal development may protect women from heart disease
Journal: BMJ (1999)

Sweetness and sucking have analgesic effect in babiesTreating pain in the newborn is essential for ethical reasons and because pain can lead to decreased oxygenation, haemodynamic instability, or increased intracranial pressure.Simple interventions such as sweet oral solutions or sucking a pacifier can reduce pain in neonates during painful minor procedures.On p 1393 Carbajal et al report the results of a comparison of the analgesic effects of these two simple interventions during venepuncture in neonates by using a behavioural pain scale.They found that the non-nutritive sucking of a pacifier was more effective than the oral administration of 30% glucose or 30% sucrose.A 30% glucose solution, which is readily available in any hospital, showed at least the same analgesic effect as a 30% sucrose solution.A synergistic analgesic effect was observed for sucrose and pacifiers.These simple and safe interventions should be widely used for minor procedures in neonates.
INTUBATION IN DIPHTHERITIC LARYNGITIS.
Journal: JAMA (1889)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fertility Control: Reprise
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Adaptation of the Eye: Its Relation to the Critical Frequency of Flicker. Reports of the Committee upon the Physiology of Vision.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Endoscopy
Authors: Edward B. Benedict
Journal: New England Journal of Medicine (1953)

NO medical progress article on the subject of endoscopy has been published in this journal for about four years. Therefore it seems pertinent to review the literature and bring the subject up to date.Bronchoscopy Physiology Morton, Klassen and Curtis1 have reported the literature pertaining to the lungs and tracheobronchial tree. Unilateral vagus section just below the recurrent laryngeal nerve but above the pulmonary plexus as performed in a series of patients with inoperable bronchiogenic carcinoma usually abolished pain of bronchial origin on the homolateral side. In 3 patients, after unilateral vagus section, electric stimulation of the homolateral main bronchus . . .
THE PREVENTION OF TUBERCULOSIS.
Authors: JOHN B. HAMILTON
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
'Ivory vertebra' in Hodgkin's disease. Restoration of trabecular pattern after therapy
Authors: M. Hertz
Journal: JAMA (1977)

BONE involvement in Hodgkin's disease does not usually occur in its early stage.<sup>1</sup>The "ivory" appearance of the vertebra is the result of a purely sclerotic change in the bone. This occurs in 10% to 15% of cases. Local pain, when present, may disappear following radiation therapy. However, the response of the ivory vertebra to therapy has not received wide comment. We report the case of a patient with Hodgkin's disease who had an ivory vertebra. Following radiation therapy, the bone was completely restored to its normal architecture. <h3>Report of a Case</h3> A 23-year-old man had had back pain of several months' duration. Examination showed enlarged supraclavicular lymph glands. A biopsy specimen from a lymph gland showed nodular sclerotic Hodgkin's disease. A chest roentgenogram was normal. In May 1974, lymphangiography was performed. No pathologic findings were noted at that time. However, the 11th dorsal vertebra was found to be
Effects of Induction and Age-Dependent Enzyme Expression on Lung Bioavailability, Metabolism, and DNA Binding of Urban Air Particulate-Absorbed Benzo[a]pyrene, 2-Nitrofluorene, and 3-Amino-1,4-Dimethyl-5H-Pyridol-(4,3)-Indole
Authors: J-P. Gotze, P. Lindeskog, C. S. I. Tornquist
Journal: Environmental Health Perspectives (1994)
Risk and response adapted treatment for early stage Hodgkin's lymphoma (ESHL): Preliminary results of an Australasian Leukaemia &amp; Lymphoma Group/Trans-Tasman Radiation Oncology Group study
Authors: A. Wirth, A. Grigg, M. Wolf, S. Davis, M. Hertzberg, D. Joseph, C. Johnson, L. Weih
Journal: Journal of Clinical Oncology (2004)

6531 Background: Risk- and response-adapted therapy of ESHL may provide an optimal balance of efficacy and toxicity. To evaluate this strategy, the following study was performed. Methods: Patients (Pt) with clinically staged ESHL were assigned to 1 of 3 treatment groups which determined the initial number of ABVD cycles administered: Group(Gp) A (Stage I-IIA, no risk factors)-3 cycles; Gp B (I-IIA with ≥ 1 risk factor (ESR > 50, bulky disease, extra-nodal disease, > 3 sites)-4 cycles; and Gp C (I-II with B symptoms)-4 cycles. The protocol specified that involved-field radiotherapy 30 Gy (IFRT) be given for Gps A and B if they attained a complete response/unconfirmed (CR/u) or partial response (PR) to initial ABVD, and for Gp C only if they attained a CR/u. Lesser responses/major toxicity led to treatment at clinician discretion. Data presented are for 12 months follow-up after completion of initial treatment. Results: There were 148 eligible pt: median age 34 yrs, 52% male, 32% stage I, 18% B-symptoms, 20% bulky disease, 5% extra-nodal. 10 pt had individualised treatment. In ABVD cycles 1, 2, 3 and 4, absolute neutrophil count <1x109/L occurred in 45%, 18%, 3% and 9%; Filgrastim was used in 55%, 65%, 64% and 69%; and lung toxicity (any grade) occurred in 4%, 6%, 7% and 15% of pt respectively. Grade 3–4 lung toxicity occurred in 2% pt (ABVD) and 1% (mediastinal IFRT). Main results are presented in the table: Conclusions: Protocol treatment was well tolerated. Response and early progression rates were promising after 3 ABVD+IFRT for pt without risk factors and, if confirmed on follow-up, support further treatment de-escalation studies for this pt group. For pt with B-symptoms or other risk factors, further follow-up is needed to assess the adequacy of 4 ABVD + IFRT, and the importance of the response to initial chemotherapy. No significant financial relationships to disclose.
Educators say MD-PhD degree programs make sense, but prove it
Authors: E. Krill
Journal: JAMA (1990)

ORGANIZERS of the first national symposium on the education of physician-scholars have released preliminary recommendations that call for a study of the success of medical-scholar training programs in preparing the nation's future medical leaders. The symposium held last November at the University of Illinois College of Medicine, Urbana-Champaign, included medical educators, MD-PhD-degree candidates, and government and corporate representatives. Among the issues discussed at the meeting, one especially nagging question remains unanswered: Are combined degree programs better than sequential degree programs in developing medical researchers, educators, and leaders? While the participants concurred on the need for well-trained physician-scientists, many questioned whether sufficient data exist to evaluate these programs. Most of the existing data that favor the combined programs are anecdotal, they say. James Blankenship, PhD, director of the MD-PhD program at the University of Texas Medical School, Galveston, however, says he has observed that concurrent-degree students become especially successful researchers. He
International Symposium on Mouse Teratocarcinoma, Oncofetal Proteins, and Human Testis Cancer
Journal: JNCI Journal of the National Cancer Institute (1979)

Journal Article International Symposium on Mouse Teratocarcinoma, Oncofetal Proteins, and Human Testis Cancer Get access JNCI: Journal of the National Cancer Institute, Volume 63, Issue 6, December 1979, Page 1493, https://doi.org/10.1093/jnci/63.6.1493-a Published: 01 December 1979
443TiP A multicenter, open-label, randomized phase II study to compare the efficacy and safety of lenvatinib in combination with ifosfamide and etoposide versus ifosfamide and etoposide in children, adolescents, and young adults with relapsed or refractory osteosarcoma (OLIE; ITCC-082)
Authors: N. Gaspar, Q. Campbell-Hewson, S.S. Bielack, M. Campbell, F. Bautista, C. Meazza, K. Janeway, F.S. Dela Cruz, S. Whittle, D.A. Morgenstern, L. Dutta, J. McKenzie, K. O'Hara, J. Huang, C.E. Okpara, B. Bidadi, K-N. Koh, B. Moreland
Journal: Annals of Oncology (2020)
Histamin: Seine Pharmakologie und Bedeutung für die Humoralphysiologie.
Journal: JAMA (1931)

The authors of this work have not only compiled an extensive and representative literature on histamine but have included every ramification in connection with histamine-like substances and actions. The work is exceedingly well organized and is presented in a critical manner. The main divisions of the book are: (<i>a</i>) The chemistry, detection, determination, formation, and occurrence of histamine; (<i>b</i>) the general pharmacology; (<i>c</i>) the special pharmacology; (<i>d</i>) the action of histamine-like substances. The work is so well done and so comprehensive that a worker in any of the numerous fields involved is well repaid in reading it.
Abstract 4974: Germline prognostic SNPs and tumor-immunity-specific expression QTL (tis-eQTL) in cancer
Authors: Xiaoqing Yu, Xuefeng Wang
Journal: Cancer Research (2019)

Abstract Introduction: Immunotherapy has produced promising results in treating cancers. Recent studies that aim to predict which patients can benefit from an immune checkpoint blocker have been largely focused on tumor molecular profiling such as tumor mutation burden and T cell infiltrations. However, whether the immunity landscape in tumor can be favorably or adversely affected by polymorphisms carried in the germline remains unknown and understudied. Methods: Here we conduct the largest investigation of tumor-immunity-specific expression QTL to date, or tis-eQTL, to systematically identify germline genetic variants that affect immune landscape in tumor. We develop a reliable statistical method for tis-eQTL mapping using RNA-seq data from heterogeneous tumor samples. We analyze genomic data from 10,380 cancer patients from 33 cancer types to reveal interactions between genetic variants (derived from germline SNP array and WES data) and immune- phenotypes derived from tumor RNAseq data. These phenotypes include immune gene expression (such as CD3E, GZMA, CXCR3 and PRF1), T-cell receptor (TCR) clonality, and antigen presenting scores (APM). Results: We observed that stratifying patients by the prioritized pathogenic germline polymorphisms exposed distinct tumor immune landscape, implicating new prognostic factors or risk genes of cancer. We further prioritize SNPs that fulfill two criteria: (a) with differential overall survival (b) have a differential expression pattern in immunogenic signatures. In support of these findings, we show that the top-ranked SNPs are associated with treatment responses to anti-PD-1 therapy in melanoma and non-small cell lung cancer. This study creates a unique and pioneering resource of prognostic germline variants with the potential to modulate immune therapy response and cancer risk, opening new avenues for developing next generation therapeutics and for personalizing risk assessment. Note: This abstract was not presented at the meeting. Citation Format: Xiaoqing Yu, Xuefeng Wang. Germline prognostic SNPs and tumor-immunity-specific expression QTL (tis-eQTL) in cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4974.
Respiratory failure from contralateral pneumothorax and atelectasis
Authors: R. P. Harbord
Journal: JAMA (1970)

A 51-year-old white man was admitted to the hospital with persistent diarrhea. He was known to have Felty's syndrome,<sup>1</sup>and had a palpable liver and spleen; the white blood cell count was 1,836/cu mm and the platelet count 60,000/cu mm; a rheumatoid deformity of his hands had been present for ten years. The hemoglobin level was 9.0 gm/100 cc and the hematocrit reading was 29%. There were ecchymoses on the patient's forearms; his legs were pigmented and there was a healing ulcer on the left leg. The patient's heart was slightly enlarged. Four years before he had been hypertensive and had congestive heart-failure. His lungs now sounded clear and the x-ray film of the chest was interpreted as being normal. Both fundi showed arteriosclerotic changes but the patient was normotensive and had a regular heart beat with a rate of 88 per minute. He was receiving digitalis (100 mg/day),
Clinical Endocrinology
Authors: Sheldon Berger
Journal: JAMA (1967)

The nine-year interval between the second and third editions of this text has been a truly remarkable one in endocrinology and metabolism, but the reader aware of the many advances will experience, I think, something of an "excitement gap" in this new edition. The volume offers the traditional principles on which the practice of clinical endocrinology rests. Cardinal features of the various endocrine syndromes are catalogued faithfully, and illustrations are of superb quality. Most sections have been either revised or extensively rewritten, and three new chapters have been added, on the hypothalamus, pineal gland, and gonadal development and sexual differentiation. Most clinicians will appreciate in particular the chapters describing the common endocrine diagnostic tests (presenting the rationale as well as the procedures) and the guide to the many commercially-available hormone preparations. This reviewer noted with pleasure the omission of certain preparations rendered obsolete by the renaissance. The authors are to
Monthly Problem in Cutaneous Medicine
Journal: JAMA (1961)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE PRODUCTION OF CARCINOMA BY EXPERIMENTAL DISSEMINATION OF EPITHELIAL CELLS.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal