tbuckley/cabot-search huggingface dataset:
The Carpal Sign in Gonadal Dysgenesis
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Quality Improvement
Authors: Mike Mitka
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Australian &amp;amp; New Zealand J Surg, Melbourne
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PLASMA PROTEINS AND THE LIVER
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 3610: Cellular fatty acid uptake is enhanced in tamoxifen-resistant breast cancer cells
Authors: Sewon Hwang, Mi-Ock Lee
Journal: Cancer Research (2019)

Abstract The most accepted therapeutic regimen for treating ER-alpha breast cancer is Tamoxifen. Yet over 30% of patients gain resistance. Recently, lipid metabolism has been rising as a new mode of cancer drug resistance. In order for a rapid growth, cancer cells show a strong avidity for lipid which they obtain by de novo lipogenesis or increasing the uptake of exogenous lipids. Lipid metabolism may confer drug resistance, but little is known about its association with endocrine resistance. Thus, we aimed to investigate the association of lipid metabolism in the context of tamoxifen resistance. First, fatty acid translocase and membrane-associated fatty acid binding protein, both of which are responsible for fatty acid uptake, were overexpressed in MCF7/TAMR-8 and T47D/TR-1, TR-2 cell lines. Also the mRNA level of fatty acid activating enzyme, long-chain fatty-acid-coenzyme A, were elevated as well. Next, through Oil-red-O staining and Nile red staining followed by FACS analysis, we examined whether tamoxifen-resistant cells actually increase fatty acid uptake. When supplemented with free fatty acids, tamoxifen-resistant cell lines showed higher efficiency in fatty acid uptake compared to the control cell lines. Subsequently when the amount of triglyceride accumulation was measured, more TG were present in resistant cells at the basal level and after free fatty acid treatment. Taken together, these results suggest lipid uptake by cancer cells may play a role in driving tamoxifen-resistance in breast cancer. Citation Format: Sewon Hwang, Mi-Ock Lee. Cellular fatty acid uptake is enhanced in tamoxifen-resistant breast cancer cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3610.
Granulomatosis Treatment
Authors: RICHARD A. DEREMEE
Journal: Annals of Internal Medicine (1979)

Letters and Corrections1 March 1979Granulomatosis TreatmentRICHARD A. DEREMEE, M.D.RICHARD A. DEREMEE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-3-436_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In reference to the NIH Conference on vasculitis in the November issue (1), I wish to make a few comments and observations on the treatment of Wegener's granulomatosis and lymphomatoid granulomatosis.Our experience with Wegener's granulomatosis includes more than 90 cases (2). Cytotoxic agents appear to provide a real advance in treatment. However, the role of glucocorticoids has been inappropriately downgraded. We have maintained patients in a quiescent state solely on prednisone therapy in the range of 60 to 100 mg on alternate days. These patients either could not tolerate or would not use cytotoxic agents for...References1. FAUCI A, HAYNES B, and KATZ P: The spectrum of vasculitis. Clinical, pathologic, immunologic, and therapeutic considerations. Ann Intern Med 89(Part 1):660-676, 1978 LinkGoogle Scholar2. DEREMEE R, MCDONALD T, HARRISON E, and COLES D: Wegener's granulomatosis. Anatomic correlates, a proposed classification. Mayo Clin Proc 51:777-781, 1976 MedlineGoogle Scholar3. DEREMEE R, WEILAND L, and MCDONALD T: Polymorphic reticulosis, lymphomatoid granulomatosis. Two diseases or one? Mayo Clin Proc 53:634-640, 1978 MedlineGoogle Scholar1. FAUCI A, HAYNES B, and KATZ P: The spectrum of vasculitis. Clinical, pathologic, immunologic, and therapeutic considerations. Ann Intern Med 89(Part 1):660-676, 1978 LinkGoogle Scholar2. FAUCI A and WOLFF S: Wegener's granulomatosis: studies in eighteen patients and a review of the literature. Medicine (Baltimore) 52:535-561, 1973 CrossrefMedlineGoogle Scholar3. REZA M, DORNFELD L, GOLDBERG L, BLUESTONE P, and PEARSON C: Wegener's granulomatosis. Long-term follow-up of patients treated with cyclophosphamide. Arthritis Rheum 18:501-506, 1975 CrossrefMedlineGoogle Scholar4. FAUCI A: Alternate-day corticosteroid therapy (editorial). Am J Med 64:729-731, 1978 CrossrefMedlineGoogle Scholar5. DALE D: Abnormalities of leukocytes, in Harrison's Principles of Internal Medicine, 8th ed., edited by THORN GW, ADAMS RD, BRAUNWALD E, ISSELBACHER KJ, PETERSDORF RG. New York, McGraw-Hill, 1977, pp. 404-411 Google Scholar6. FAUCI A: Granulomatous vasculitides: distinct but related (editorial). Ann Intern Med 87:782-783, 1977 LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: RICHARD A. DEREMEE, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPulmonary Angiitis and Granulomatosis 1 March 1979Volume 90, Issue 3Page: 436-437KeywordsCytotoxinsVasculitisWegener granulomatosis ePublished: 1 December 2008 Issue Published: 1 March 1979 PDF downloadLoading ...
CONTEMPORARY USE OF LASER DURING PERCUTANEOUS CORONARY INTERVENTION: LONG-TERM RESULTS FROM THE LASER VETERANS AFFAIRS (LAVA) MULTICENTER REGISTRY
Authors: Judit Karacsonyi, Ehrin J. Armstrong, Huu Tam Truong, Jose R. Martinez-Parachini, Barbara Danek, Aris Karatasakis, Peter Tajti, Rahel Iwnetu, Michele Roesle, Houman Khalili, Ryan Tsuda, Damianos Kokkinidis, Imre Ungi, Subhash Banerjee, Emmanouil S. Brilakis, Bavana Rangan
Journal: Journal of the American College of Cardiology (2018)
AMERICAN MEDICAL COLLEGES.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The scientists' campaign against the Strategic Defense Initiative
Authors: J. B. Kogut
Journal: JAMA (1987)

IN HIS March 1983 speech announcing the Star Wars program (officially called the Strategic Defense Initiative [SDI]), President Reagan called on this nation's scientists and engineers to develop a defensive shield against Soviet land-based nuclear missiles. Therefore, scientists and engineers were placed in a special position to evaluate the program's prospects, and they had a responsibility to respond to the President's call based on their informed assessment of the program. This article documents an unprecedented response to a military program: a national boycott of Star Wars research in which science and engineering professors have pledged neither to solicit nor accept SDI research funds. In each of well over 120 research departments in relevant fields, half or more of the faculty members have joined the boycott. The pledge signers include a clear majority of the nearly 1000 faculty members in the nation's 20 top physics departments. There are over 12 000
Editorial: Immunisation in the two-thirds world.
Journal: BMJ (1975)

incisions, an extra reason for resisting further laparotomy as long as possible in such cases.Patients treated expectantly must be watched carefully in the first few days to ensure that complications do not occur.Surgical treatment is indicated for obstruction or perforation4 of the intestinal tract; for toxaemia from absorption of chemi- cal constituents of the object; or if the length, size, or shape of the object suggests that it will not pass.Radiographs may not show the object, and it must be borne in mind that lead is now used infrequently in the manufacture of toys and glass, and so these may no longer be radio-opaque.One recent development is the use of fibre-endoscopy to remove objects from the stomach as well as the oesophagus. 5
Medical Nemesis
Authors: C. R. Porteous
Journal: BMJ (1974)

2-Chloro-4-(ethylamino)-6-(isopropylamino)-<i>s</i>-triazine (atrazine, ATR) is a toxicologically important and widely used herbicide. Recent studies have shown that it can elicit neurological, immunological, developmental, and biochemical alterations in several model organisms, including in mice. Because disposition data in mice are lacking, we evaluated ATR9s metabolism and tissue dosimetry after single oral exposures (5–250 mg/kg) in C57BL/6 mice using liquid chromatography/mass spectrometry (Ross and Filipov, 2006). ATR was metabolized and cleared rapidly; didealkyl ATR (DACT) was the major metabolite detected in urine, plasma, and tissues. Plasma ATR peaked at 1 h postdosing and rapidly declined, whereas DACT peaked at 2 h and slowly declined. Most ATR and metabolite residues were excreted within the first 24 h. However, substantial amounts of DACT were still present in 25- to 48-h and 49- to 72-h urine. ATR reached maximal brain levels (0.06–1.5 μM) at 4 h (5–125 mg/kg) and 1 h (250 mg/kg) after dosing, but levels quickly declined to &lt;0.1 μM by 12 h in all the groups. In contrast, strikingly high concentrations of DACT (1.5–50 μM), which are comparable with liver DACT levels, were detectable in brain at 2 h. Brain DACT levels slowly declined, paralleling the kinetics of plasma DACT. Our findings suggest that in mice ATR is widely distributed and extensively metabolized and that DACT is a major metabolite detected in the brain at high levels and is ultimately excreted in urine. Our study provides a starting point for the establishment of models that link target tissue dose to biological effects caused by ATR and its in vivo metabolites.
IA. Medical Schools in the United States
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hepatic Lobectomy for Metastatic Cancer
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Emergency medicine and critical care: JAMA's new section
Authors: C. M. Rinke
Journal: JAMA (1983)

In this issue ofThe Journal, we are premiering the publication of a new section, CONCEPTS IN EMERGENCY AND CRITICAL CARE (p 1081). This section will provide a forum dedicated to informing our readers about advances in the understanding and technology of critical care and emergency medicine. These two new specialties have emerged on the medical scene in the past five to ten years and have captured the interest and enthusiasm of many younger physicians. Their resultant research efforts have advanced the science and the physiology of life-threatening illnesses and spawned a proliferation of knowledge. In CONCEPTS IN EMERGENCY AND CRITICAL CARE, we hope to stimulate you with a provocative fare of discussion, review, and controversy from these exciting, spanking new medical disciplines. The goals of the section are twofold: (1) to discuss a scientific or clinical concept directly affecting the treatment of critically ill patients and (2) to keep
A NEW RUBBER FOOT.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE SIGNIFICANCE OF DECREASED HYDROCHLORIC ACID IN GASTRIC CANCER.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Validation du score EGGIM (Endoscopic Grading of Gastric Intestinal Metaplasia): résultat d’une étude prospective multicentrique
Journal: Endoscopy (2019)

La métaplasie intestinale (MI) gastrique est une lésion pré-néoplasique, favorisant l’apparition de dysplasie puis d’adénocarcinome gastrique de type intestinal. La classification OLGIM (Operative Link On Gastric Intestinal Metaplasia) est une classification histologique permettant de stratifier le risque néoplasique en fonction de la présence et de l’intensité de la métaplasie gastrique sur 5 échantillons biopsiques (2 de l’antre, 2 du fundus et 1 de l’angulus). Un score supérieur ou égal à III correspond à un risque élevé justifiant une surveillance endoscopique rigoureuse. Néanmoins, des données récentes ont démontré l’intérêt de la coloration électronique par NBI (Narrow Bind Imaging) dans le diagnostic de la MI et de la dysplasie gastrique. Cela a permis la création d’une classification endoscopique (EGGIM), qui permet de prédire le risque de développement d’adénocarcinome gastrique, en fonction de l’évaluation endoscopique de la MI en NBI.