tbuckley/cabot-search huggingface dataset:
Glossary of cardiologic terms related to physical diagnosis and history. 3. Anterior chest movements. The ventricles, the atria, and the great vessels
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Carbon monoxide levels and methylene chloride exposure
Authors: C. S. Strande
Journal: JAMA (1978)

<h3>To the Editor.—</h3> The letter in<i>JAMA</i>(239:2341, 1978) on carbon monoxide (CO) levels from methylene chloride exposure deserves a comment. While the conversion of methylene chloride to CO in vivo is well recognized, the mechanism, magnitude, and importance of this phenomenon are less well known. It is unfortunate, therefore, that potentially useful contributions to our knowledge in this area appear in the form of poorly documented accounts like the one presented in the aforementioned letter. The correspondents conclude that the greatest threat to their patients was the continued high level of carboxyhemoglobin (COHb). In other words, their diagnosis in both cases is (acute) CO poisoning. In the range of 10% to 30% COHb, the expected clinical symptoms in order of decreasing incidence are as follows: headache, 94%; dizziness, 83%; hypertension, 63%; musculoskeletal weakness, 59%; and nausea, 31%.<sup>1</sup>Not one of these symptoms is described in either of their
Bureau of Legal Medicine and Legislation
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction
Journal: BMJ (1951)

ANY QUESTIONS?BR DIC sou sodium benzoate; shellfish, except oysters.Severe sodium restriction involves all the above limitations and, in addition, the use of salt-free bread, butter, or kosher margarine, and milk should be restricted to half a pint daily.Any foods made with baking-powder, soda, or prepared flour, also beer and stout, should be forbidden.Low-sodium diets tend to be dull and monotonous because they are tasteless.Meals may be made appetizing by vary- ing the menu and by the skilful use of herbs and seasoning in cooking-e.g., sage and onion with pork served with spiced apple sauce.The frequent use of mustard and vinegar, particularly in the preparation of mayonnaise and salad dressing, will also do much to counteract the tasteless- ness of a low-sodium diet.Salt substitutes are not advised. MENUBreakfast.-Fruitjuice and/or stewed prunes.Egg or fish.(Unsalted) buttered toast and jam or marmalade.Weak tea or coffee with sugar.Lunch.-Egg, home-made unsalted cream cheese, meat, fish, poultry, or rabbit Vegetables. (Unsalted) bread and butter.Jelly, pastry, or fruit.Dinner.-Vegetable soup, baked potato, protein food as at lunch.Vegetables or salad.(Unsalted) bread and butter.Baked apple and custard.Black coffee.
Allergy abstracts
Authors: Murray Albert Brooklyn, N Eugene, Walzer Bridgeporr, Neil Goldman, Ossining Sheldon Berger Freehold, Harold Friedman, Cleveland Ohio, Monroe Coleman, Srczmford Corm, Brooklyn Siegel, Kailin Eloise, Wash Sequim, Spring Stein, Matthew Walzer Brooklyn, N Asthma
Journal: Journal of Allergy and Clinical Immunology (1977)
Introduction
Journal: JAMA (1968)

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Abolition of Marine-Hospital Dues.
Journal: JAMA (1884)

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Hybrid Words
Authors: James Ransom
Journal: JAMA (1977)

The duty owed by every educated speaker of a language is to let it live its own life without undue interference from authoritarian proscriptions. Elsewhere in this issue (p 2043), Dirckx has undertaken to say what may be the best last word on a problem of vocabulary formation that has been coming up for discussion periodically ever since the first physician with a classical education found a need to coin a word out of familiar elements drawn from Greek and Latin. Thus, the GE tract is not that but the GI tract. To say that GI<i>ought</i>to be GE is like making rules for birds to follow during their brief habitation of trees. Our language is not given but bailed to us, and we owe it a duty of due care while it is in our fleeting possession. Our solemn charge as editors and writers is not to violate
Bacteria: The Silent Killer During Flu Pandemics?
Authors: Thais Mauad, Ludhmila Abrahão Hajjar, Luiz Fernando Ferraz da Silva, Denise Schout, Filomena Regina Barbosa Gomes Galas, Marisa Dolhnikoff, Paulo Hilário Nascimento Saldiva
Journal: American Journal of Respiratory and Critical Care Medicine (2010)
DNA Methylation and Differentiation
Authors: Lesley A. Michalowsky, Peter A. Jones
Journal: Environmental Health Perspectives (1989)

The methylation of specific cytosine residues in DNA has been implicated in regulating gene expression and facilitating functional specialization of cellular phenotypes. Generally, the demethylation of certain CpG sites correlates with transcriptional activation of genes. 5-Azacytidine is an inhibitor of DNA methylation and has been widely used as a potent activator of suppressed genetic information. Treatment of cells with 5-azacytidine results in profound phenotypic alterations. The drug-induced hypomethylation of DNA apparently perturbs DNA-protein interactions that may consequently alter transcriptional activity and cell determination. The inhibitory effect of cytosine methylation may be exerted via altered DNA-protein interactions specifically or may be transduced by a change in the conformation of chromatin. Recent studies have demonstrated that cytosine methylation also plays a central role in parental imprinting, which in turn determines the differential expression of maternal and paternal genomes during embryogenesis. In other words, methylation is the mechanism whereby the embryo retains memory of the gametic origin of each component of genetic information. A memory of this type would probably persist during DNA replication and cell division as methylation patterns are stable and heritable.
<i>Erratum</i>: Vol. 66, No. 40
Journal: MMWR Morbidity and Mortality Weekly Report (2017)

the first sentence of footnote " § § " should have read "All 50 states and DC required 2 doses of a measles-containing vaccine."On page 1077, in Table 1, footnote "**" should have read "Most states require 2 doses of MMR; Alaska, New Jersey, and Oregon require 2 doses of measles, 1 dose of mumps, and 1 dose of rubella vaccines.Georgia, New York, New York City, North Carolina, Pennsylvania, and Virginia require 2 doses of measles and mumps, and 1 dose of rubella vaccines.Iowa requires 2 doses of measles and 2 doses of rubella vaccines."
Thomas Peacock
Authors: P. J. Bishop
Journal: JAMA (1968)

<h3>To the Editor:—</h3> Your editorials on famous figures in medicine are enjoyable, and found me particularly interested in the one on Thomas Bevill Peacock (<b>203</b>:801, 1968). The library of the Institute of Diseases of the Chest of the University of London contains the surviving portion of his personal library. The collection, housed in a typical Victorian bookcase, for many years stood in the entrance of the London Chest Hospital at Victoria Park. In 1960 the medical staff of this, our sister hospital, deposited the collection here in the Consultant's Common Room of the Brompton hospital. I am happy to say that its contents are still used, both to supplement our own small historical collection and for display purposes.
Synthesis of insulinlike growth factor binding proteins and of the acid-labile subunit in primary cultures of rat hepatocytes, of Kupffer cells, and in cocultures: Regulation by insulin, insulinlike growth factor, and growth hormone
Authors: J Scharf, G Ramadori, T Braulke, H Hartmann
Journal: Hepatology (1996)

The adult liver is the main source of circulating insulinlike growth factors (IGFs) and their serum binding proteins (IGFBPs) including the acid-labile subunit (ALS), a component of the ternary binding protein complex. Within the liver, the biosynthesis of individual proteins has been attributed to different cell populations, e.g., that of ALS to hepatocytes and that of IGFBP-3 to nonparenchymal cells. Ligand and immunoblotting as well as Northern blotting analyses were used to study synthesis of IGFBPs and their hormonal regulation in cultured adult rat hepatocytes, Kupffer cells (KCs), and cocultures. In hepatocytes, synthesis of IGFBP-1, -2, and -4 was observed; insulin and IGF-I decreased that of IGFBP-1, and -2 while increasing that of IGFBP-4. KCs synthesized IGFBP-2, and -3, insulin and IGF-I showing no effect. In cocultures, however, synthesis of IGFBP-3 was stimulated by insulin and IGF-I. By immunocytochemistry IGFBP-3 biosynthesis was localized to KCs exclusively. When pore membranes were used for separation of hepatocytes and KCs in coculture, this insulin-stimulatory action on IGFBP-3 synthesis was preserved. Growth hormone (GH) did not affect biosynthesis of IGFBPs. Expression of ALS was localized in hepatocytes only. Insulin, IGF-I, and GH increased ALS expression. It can be concluded that biosynthesis of individual IGFBPs and of ALS are compartmentalized in adult rat liver and are distinctly regulated by insulin, IGF-I, and GH. The insulin-dependent stimulation of IGFBP-3 synthesis in KCs appears to require a diffusable mediator derived from hepatocytes.
Platelet transfusion reaction due to Yersinia enterocolitica
Authors: M. J. Kuehnert
Journal: JAMA (1997)

<h3>To the Editor.</h3> —Although the safety of more than 20 million units of blood products transfused in the United States each year has improved through modifications in donor screening and testing in response to the human immunodeficiency virus epidemic, residual risk remains for acquisition of infection caused by emerging pathogens, including<i>Yersinia enterocolitica</i>.<sup>1,2</sup> <h3>Report of a Case.</h3> —In March 1997, a 57-year-old man with acute granulocytic leukemia was transfused with a unit of pooled platelet concentrate. Forty-five minutes after the infusion began, the patient developed severe rigors; the transfusion was stopped. Bacterial contamination of the platelet concentrate was suspected. Although Gram stain of the unit was negative, culture of the remaining platelet concentrate yielded<i>Y enterocolitica</i>, serotype 0:3. Blood cultures drawn at the time of the reaction, while the patient was receiving imipenem and gentamicin, did not grow bacteria. Six donors contributed to the pooled platelet unit. Of the
Case-mix adjustment: making bad apples look good
Authors: H. G. Welch
Journal: JAMA (1995)

<h3>To the Editor.</h3> —Dr Salem-Schatz and colleagues have done admirable work investigating the influence of case-mix adjustment on physician profiles.<sup>1</sup>Readers should be aware, however, that case-mix adjustment may make bad apples look good. It is important to step back and consider the rationale for adjusting physician profiles in general. Adjustment is a mechanism to control for factors that confound the relationship between physician and practice style. Ideally, the intent is to remove the effect of exogenous factors (ie, those in which the physician has no influence). Age and sex adjustment serves as the classic example. On the other hand, it is important not to adjust away endogenous factors (ie, those that the physician can influence). For example, it would be silly to adjust physician profiles for physician income. In the private sector, at least, one would be adjusting for a factor that is strongly related to what one
15. Nitrofurantoin
Journal: JAMA (1977)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Phase II Trial of Temozolomide Plus the Matrix Metalloproteinase Inhibitor, Marimastat, in Recurrent and Progressive Glioblastoma Multiforme
Authors: Morris D. Groves, Vinay K. Puduvalli, Kenneth R. Hess, Kurt A. Jaeckle, Pamela Peterson, W.K. Alfred Yung, Victor A. Levin
Journal: Journal of Clinical Oncology (2002)

PURPOSE: Novel therapies are needed for patients with recurrent glioblastoma multiforme (GBM). Because there is evidence that temozolomide (TMZ) has some activity in GBM and is well tolerated, and because of laboratory evidence that metalloproteinases are important in glioma cell invasion, the combination of TMZ and the matrix metalloproteinase inhibitor marimastat (MRM) in patients with recurrent GBM was studied. PATIENTS AND METHODS: Forty-four patients with recurrent GBM after standard radiotherapy were enrolled. For 19 patients, this therapy was their first chemotherapy after tumor progression after irradiation; 25 others had received chemotherapy previously. TMZ 150 to 200 mg/m 2 days 1 to 5 and MRM 50 mg days 8 to 28 was administered at 28-day intervals for two cycles; then patients were reevaluated. Treatment continued until progression of tumor or toxicity developed. RESULTS: Joint and tendon pain was the major therapy-related toxicity and was reported in 47% of patients. Five patients (11%) were removed from the study because of intolerable joint pain. For all patients, the progression-free survival (PFS) at 6 months was 39%. Median PFS was 17 weeks, median overall survival was 45 weeks, and 12-month PFS was 16%. CONCLUSION: The combination of TMZ and MRM resulted in a PFS at 6 months that exceeded the literature target by 29%. This drug combination met phase II study criteria; further study in recurrent patients with GBM might be warranted. Further study of therapy-induced joint pain is necessary.
Surgical approach to the ophthalmopathy of Graves' disease
Authors: Joseph Ogura, Stanford Wessler, Louis V. Avioli
Journal: JAMA (1971)

Dr. Steven Raffin, Senior Assistant Resident in Medicine, Jewish Hospital of St. Louis, and Assistant in Medicine, Washington University School of Medicine: A 35-year-old white woman was hospitalized with a nine-month history of progressive "eye swelling," visual loss bilaterally, and frontal headaches. One year prior to admission, the diagnosis of hyperthyroidism had been established and subtotal thyroidectomy performed. The patient had been followed up subsequently in the outpatient clinic and continued to maintain the post-operative euthyroid state without supplemental thyroid medication. The most recent serum protein-bound iodine value, obtained one week prior to admission, was 4.5 μg/100 ml. Physical examination revealed a well-developed woman in moderate distress. The blood pressure was 178/120 mm Hg; pulse rate was 76 beats per minute and regular, and respiratory rate was 18 per minute. The most striking findings were severe, bilateral papilledema, corneal ulcerations, proptosis, conjunctival edema, and chemosis (Fig 1,<i>right</i>). Also apparent
XIPHISTERNAL OR PERICARDIAL CHISELSOUND, WITH ITS PRACTICAL APPLICATION
Authors: F. J. Brown
Journal: BMJ (1856)

a atick of phimasia dolens, under wLhich she is now "Alter rupturing the membranes, the hmorrhge enasued; and it was very fortunate that the uterus so immediatey and powerfully after the administra- Mon of the ergot; for if the birth had been longer delayed, most liely the child would have been lost."cWe have her another example of phlebitis contingent on plcenta prmvisa" [To be continued.
Foodborne Outbreak of Cryptosporidiosis—Spokane, Washington, 1997
Journal: JAMA (1998)

On December 29, 1997, the Spokane Regional Health District received reports of acute gastroenteritis among members of a group attending a dinner banquet catered by a Spokane restaurant on December 18. The illness was characterized by a prolonged (3-9 days) incubation period and diarrhea, which led public health officials to suspect a parasitic cause of the illness. Eight of 10 stool specimens obtained from ill banquet attendees were positive for Cryptosporidium using both modified acid-fast and auramine-rhodamine staining of concentrated specimens. This report summarizes the epidemiologic investigation of the outbreak, which suggests that foodborne transmission occurred through a contaminated ingredient in multiple menu items.
BELGIUM
Journal: JAMA (1924)

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Marriages
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal