tbuckley/cabot-search huggingface dataset:
A novel platform for radioimmunotherapy. Extracorporeal depletion of biotinylated and 90Y-labeled anti-CD20 in patients with refractory B-cell lymphoma
Authors: O. Linden, J. Kurkus, M. Garkavij, E. Cavallin-Ståhl, T. Ohlsson, R. Nilsson, B. E. Sandberg, M. Ljungberg, S.-E. Strand, J. Tennvall
Journal: Journal of Clinical Oncology (2004)

6576 Background: Radioimmunotherapy is limited by the absorbed dose to radiosensitive organs. The bone marrow is the first dose limiting organ and the absorbed dose to it is mainly derived from unbound radiolabeled MAb in the circulation. A removal of these circulating MAb should, in patients (pts) with a not heavily infiltrated bone marrow, permit the administration of higher amounts of radioactivity. This would then translate into a higher dose to the tumor. Method: A lymphoma setting was chosen to test the feasibility of the adsorption procedure, (ECAT). A novel device MitraDep® was tested, by which biotinylated and radiolabeled MAb can be removed from the circulation, when whole blood is passed over a filter coated with avidin .The MAbs were radiolabeled and biotinylated using MitraTag™, a moiety consisting of DOTA and biotin. Pts with refractory B-cell lymphoma received infusions with 250mg/m2 cold rituximab and 150 MBq 111In-anti-CD20-biotin for targeting. A week later pts were treated with another 250mg/m2 rituximab followed by injection of 11–15 MBq/kg 90Y-anti-CD20-biotin. 40 to 48 h later ECAT was performed. Results: All 8 pts receiving 111In-anti-CD20-biotin showed clear tumor uptake. One patient had an allergic reaction and did therefore not proceed. The other 7 pts received RIT and subsequent ECAT. The mean depletion of 90Y-anti-CD20-biotin in whole blood after ECAT was 96% (range 92–98%). The depletion of 90Y in the lungs was 62%, in the liver and kidneys 40%. No effects on pts'vital signs, no adverse effects on hematological or coagulation parameters and no significant complement or bradykinin activation were observed during ECAT. 3 of 7 pts exhibited an objective response. Conclusion: The ECAT procedure using MitraDep was efficient, safe and reproducible. Biotinylated 111In antiCD20 MAb targeted in all cases and seems safe. 90Y-anti-CD20-biotin preceded by rituximab and followed by ECAT can induce objective remissions in pts with refractory B-cell lymphoma. Based on the effectiveness of the depletion and absence of significant adverse effects a dose-escalation study will be initiated. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Mitra Medical Technology AB Mitra Medical Technology AB
Preparation, sedation, and monitoring
Authors: A. Riphaus, T. Wehrmann
Journal: Endoscopy (2013)

Endoscopy Essentials Reviews in the Endoscopy Essentials series cite publications from the past year which, in the authors’ opinion, reflect the state-of-the-art in endoscopy. Alongside a short summary of each paper, authors explain why they consider their selected articles to be of importance.
Myocardial infarction in a national-class swimmer
Authors: P. G. Hanson
Journal: JAMA (1982)

MYOCARDIAL infarction (MI) and sudden death are periodically reported in previously healthy young adults during strenuous exercise or athletic competition. The majority of these cases are explained by latent coronary atherosclerosis, anomalous coronary morphological conditions, or hypertrophic cardiomyopathy.<sup>1</sup>However, exercise-related MI may also occur in young persons without apparent abnormalities of coronary or myocardial structure.<sup>2-4</sup>A nontransmural MI occurred in a national-caliber swimmer during intense training. Subsequent cardiac catheterization and radionuclide angiographic studies disclosed patent coronary arteries and normal ventricular function. <h3>Report of a Case</h3> A 20-year-old man, who was a varsity swimmer, complained of severe substernal chest pain while performing a routine 15-km training session. The pain was unaffected by his position or breathing movements are gradually resolved after one hour of rest. He remained asymptomatic until 3 AM the following morning, when he was awakened by similar pain that prompted medical attention. He denied having a
4. Comprehensive Medical Evaluation and Assessment of Comorbidities: <i>Standards of Medical Care in Diabetes—2020</i>
Journal: Diabetes Care (2019)

The American Diabetes Association (ADA) “Standards of Medical Care in Diabetes” includes the ADA’s current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA Professional Practice Committee, a multidisciplinary expert committee (https://doi.org/10.2337/dc20-SPPC), are responsible for updating the Standards of Care annually, or more frequently as warranted. For a detailed description of ADA standards, statements, and reports, as well as the evidence-grading system for ADA’s clinical practice recommendations, please refer to the Standards of Care Introduction (https://doi.org/10.2337/dc20-SINT). Readers who wish to comment on the Standards of Care are invited to do so at professional.diabetes.org/SOC.
PROTECTIVE EFFECT OF VACCINATION AGAINST INDUCED INFLUENZA B 1
Authors: Jonas E. Salk, Harold E. Pearson, Philip N. Brown, Thomas Francis
Journal: Journal of Clinical Investigation (1945)

In the previous paper (1), evidence was presented to show that subcutaneous vaccination of human subjects with a vaccine containing in- activated influenza viruses, Types A and B, was followed by an increased resistance to experi- mentally induced infection with influenza virus, Type A. The present report deals with the clini- cal and laboratory results of a similar study illustrating the effect of subcutaneous vaccination upon resistance of another group of individuals to induced infection with influenza virus, Type B. 10-3, 4, 4 10-J 3,4,4 10-4, 4, 5 10-i 5, 6, +++ fected allantoic fluid that was employed for the human infection.The mouse lung tissue consisted of a pool of lungs containing virus which had been passed 1 to 5 times in mice, after 9 to 12 passages in ferrets.Allantoic fluid from the second and third egg transfers was concen- trated approximately 10-fold by adsorption onto red blood cells of the embryo and elution into physiological salt solution (3).Fluid containing the virus was placed in a rubber-capped vaccine vial and stored at 40 C. for one week before use.Tests for sterility were made.At the time the fluid was used to infect humans it had the following properties:(1) Infectivity for mice: 10-* 6, 7, +++ 10-7++++, +++, +++ (Figures denote day of death of individual mice.Plus signs refer to degree of pulmonary consolidation in survivors autopsied on the 11th day.)A brief summary of the dinical results has been reported (2). MATERIALS AND METHODSVaccine.The vaccine employed was the same as that used in the preceding study (1) and contained influenza virus of both Types A and B. The immunizing capacity
EXPERIMENTAL TRANSPLANTATION OF INTESTINE INTO THE STOMACH.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Cholera Bacillus.
Journal: JAMA (1884)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Medical Department of the United States Army in the World War. Volume I: The Surgeon General's Office. Prepared under the Direction of Major Gen. M. W. Ireland, M.D., Surgeon General of the Army.
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Radiotherapy in the Diseases of Women
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Promise
Authors: Veneta Masson
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tree Stand-Related Injuries among Deer Hunters—Georgia, 1979-1989
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Genetic Privacy
Authors: Pamela Sankar
Journal: Annual Review of Medicine (2003)

During the past 10 years, the number of genetic tests performed more than tripled, and public concern about genetic privacy emerged. The majority of states and the U.S. government have passed regulations protecting genetic information. However, research has shown that concerns about genetic privacy are disproportionate to known instances of information misuse. Beliefs in genetic determinacy explain some of the heightened concern about genetic privacy. Discussion of the debate over genetic testing within families illustrates the most recent response to genetic privacy concerns.
STATE CARE OF INEBRIATES.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Interpreting hospital mortality data. How can we proceed?
Authors: K. L. Kahn
Journal: JAMA (1988)

DATA about whether patients live or die following short-term—care hospitalization can serve at least two purposes: (1) to determine if hospital performance has improved or deteriorated over time and (2) to determine if performance differs across hospitals at one given time. Hospital mortality figures have been used in this manner primarily because such data are readily available, easy to understand, and potentially important to the public. However, if mortality data are to be used for these purposes, they must reflect actual differences in the quality of care, not other factors, such as patient sickness at admission. We have been studying hospital mortality and other outcomes as part of a clinically detailed national study to assess the impact of the diagnosis related group (DRG)-based prospective payment system (PPS) on the quality of care for hospitalized Medicare patients. In this report we document and justify some of the design decisions we made
Aspiration pneumonia following intravenous administration of alcohol during labor
Authors: B. S. Greenhouse
Journal: JAMA (1969)

A pregnant woman aspirated highly acid gastric contents during anesthesia for a cervical circlage procedure after she had received alcohol intravenously to stop premature labor. Pulmonary lavage extended and intensified the pneumonitis. She required several days of intensive pulmonary therapy with intermittent positive pressure ventilation monitored by frequent blood-gas determinations in addition to treatment with steroids and antibiotics. Alcohol is a potent gastric acid secretagogue. Patients in premature labor treated with alcohol intravenously must be considered to have stomach contents.
Inconsistencies and Open Questions regarding Low-Dose Health Effects of Ionizing Radiation
Authors: Rudi H. Nussbaum, Wolfgang Kohnlein
Journal: Environmental Health Perspectives (1994)

The effects on human health of exposures to ionizing radiation at low doses have long been the subject of dispute. In this paper we focus on open questions regarding the health effects of low-dose exposures that require further investigations. Seemingly contradictory findings of radiation health effects have been reported for the same exposed populations, or inconsistent estimates of radiation risks were found when different populations and exposure conditions were compared. Such discrepancies may be indicative of differences in sensitivities among the applied methods of epidemiological analysis or indicative of significant discrepancies in health consequences after comparable total exposures of different populations under varying conditions. We focus first on inconsistencies and contradictions in presentations of the state of knowledge by different authoritative experts. We then review studies that found positive associations between exposure and risks in dose ranges where traditional notions (generalized primarily from high-dose studies of A-bomb survivors or exposed animals) would have predicted negligible effects. One persistent notion in many reviews of low-dose effects is the hypothesis of reduced biological effectiveness of fractionated low-dose exposures, compared to that of the same acute dose. This assumption is not supported by data on human populations. From studies of populations that live in contaminated areas, more and more evidence is accumulating on unusual rates of various diseases other than radiation-induced malignancies, health effects that are suspected to be associated with relatively low levels of internal exposures originating from radioactive fallout. Such effects include congenital defects, neonatal mortality, stillbirths, and possibly genetically transmitted disease. A range of open questions challenges scientists to test imaginative hypotheses about induction of disease by radiation with novel research strategies.
Leads from the MMWR. Acute illness epidemic. West Bank--Jerusalem
Journal: JAMA (1983)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical Pediatrics.
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal