tbuckley/cabot-search huggingface dataset:
Medical Education and Hospitals
Journal: JAMA (1961)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
QUININ IN INFLUENZAL PNEUMONIA
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Polio Vaccination
Authors: Hans J. Eggers
Journal: JAMA (1987)

<h3>To the Editor.—</h3> We were pleased to see the careful analysis of vaccine-associated paralytic poliomyelitis by Nkowane et al.<sup>1</sup> One important point concerns the estimate of the true risk of vaccineassociated poliomyelitis in susceptible individuals.<sup>2-4</sup>This is of more than theoretical interest: in view of the changing epidemiologic situation in developed and developing countries, one has to assume that more and more children being vaccinated for the first time will be fully susceptible to all three poliovirus types. Thus, the rate of vaccineassociated poliomyelitis may be increasing. Needless to say, this does not call into question the extraordinary blessings of oral poliomyelitis vaccination, particularly in developing countries. But, whenever feasible, consideration should be given to a combined vaccination strategy using inactivated poliomyelitis vaccine for the first polio vaccinations in early infancy, together with diphtheria, tetanus, and pertussis vaccination. This protocol carries the additional advantage of avoiding the possible
Clumsy Children
Authors: C. Burns
Journal: BMJ (1963)

MEDICAL JOUR~NAL failure to reduce the exercise to manageable numbers by a more precise identification of those most at risk.Mass radiography units in big numbers crossed the border in 1957 to deal with the epidemic of tuberculosis in Glasgow-a new endeavour and a rewarding invasion.Selective surveys should, as you indicate, now displace communal and factory surveys, but selection should not only mean the intermittent examination of special groups-immigrants, residents in model lodging houses, etc.-but must mean sequential x-rays and tuberculin tests, so that aetiological riddles may be resolved and case detection founded on precise knowledge.The mass radiography departments have made a fine contribution in the past to the control of tuberculosis, and in a very few years, by appropriate selection of subjects, they could construct a national case index register which would rationalize case detection for the era of eradication which we may hope is now imminent.
National Research Council endorses human gene mapping project
Authors: B. Merz
Journal: JAMA (1988)

THE HUMAN GENOME Initiative has received another vote of confidence. The National Research Council, an arm of the National Academy of Sciences that is empowered by Congress to advise the federal government, is recommending a $3-billion effort to map and sequence the human genome. The committee advises appropriating $200 million each year for the project over the next 15 years. It emphasizes that funding should be generated de novo, not diverted from existing biologic and medical research efforts. As envisioned, the project would be executed in two stages: genome mapping and DNA sequencing. The first would involve preparing both physical maps, in which previously identified DNA segments are aligned in proper order on the appropriate chromosome, and genetic maps, which demonstrate the frequency with which two traits are likely to be inherited together (<i>JAMA</i>1987;258:1131-1132). The recommendation paralleled provisions of two Senate bills—the science initiative bill introduced last summer by
Meta-analysis of Prevention of Nonvertebral Fractures by Alendronate
Authors: Susan D. Ross
Journal: JAMA (1997)

<h3>To the Editor.</h3> —The recent review by Dr Karpfand colleagues<sup>1</sup>of the effect of alendronate on the incidence of nonvertebral fractures in postmenopausal women with osteoporosis presents a very clean and powerful analysis. However, the review provides no details of the search strategy or the study selection criteria, and there is no evidence that a review protocol was written a priori. Such reporting (and performance) defects have been previously noted to be widespread in published meta-analyses,<sup>2</sup>but I would have hoped that the recent evolution of the science of systematic reviews<sup>3</sup>and the adoption of the CONSORT (Consolidated Standards of Reporting Trials) philosophy and principles<sup>4</sup>might have prevented the publication of what appears to be important and well done research without these necessary details.
Archives of Environmental Health, Chicago
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diazoxide
Authors: Jan Koch-Weser
Journal: New England Journal of Medicine (1976)

DIAZOXIDE, a benzothiadiazine derivative closely related chemically to the thiazide diuretics (Fig. 1), lacks the 7-sulfonamide group and a halogen substitution at the 6 position, does not inhibit carbonic anhydrase, and is devoid of chloriuretic and natriuretic activity. It is a potent and rapidly acting antihypertensive agent and, after 12 years of clinical trial, was marketed three years ago for intravenous therapy of hypertensive emergencies.Mechanism of ActionDiazoxide exerts its hypotensive action entirely by reducing vascular resistance in all circulatory beds through direct relaxation of arteriolar smooth muscle.1 2 3 4 5 6 The cellular mechanism of this effect is not yet understood; it . . .
Osteopaths using the title MD
Authors: V. R. Greenfield
Journal: JAMA (1983)

IN ALL 50 states and the District of Columbia, osteopathic physicians are licensed to practice medicine and surgery. However, some osteopaths have asserted that the term "osteopathy" is unfamiliar to the public, making it more difficult for an osteopath to become established in a community. Therefore, some osteopaths have used the degree designation "MD" after their name rather than the degree designation "DO"—a practice that has met with opposition from certain state boards of medical examiners. Such was the case in<i>Maceluch v Wysong</i>, 680 F2d 1063 (5th Cir 1983), and<i>Eatough v Albano</i>, 673 F2d 671 (3d Cir),<i>cert denied</i>, 102 SCt 2931 (1982). In the<i>Maceluch</i>case, two physicians who graduated from colleges of osteopathy sued officers and various members of the Texas State Board of Medical Examiners because the board declined to issue the osteopaths licenses bearing the initials "MD." Neither the Texas Osteopathic Association nor the
Abstract 2610: The FOXC2 transcription factor promotes growth of melanoma cells in both <i>in vitro</i> and <i>in vivo s</i>ettings
Authors: Corey J. Williams, Coleman E. Johnson, David Z. Bushhouse, Kristian M. Hargadon
Journal: Cancer Research (2019)

Abstract Melanoma, a cancer derived from pigment-producing melanocytes of the skin, is a highly aggressive cancer characterized by rapid growth and metastasis. Recent evidence has emerged demonstrating that overexpression of the FOXC2 transcription factor contributes to tumor progression in many cancer types, but the role of FOXC2 in melanoma progression has not previously been studied. Using CRISPR-Cas9 gene editing technology, we have generated and characterized a novel FOXC2 knockout B16-F1 melanoma cell line (B16-F1ΔFOXC2). In comparative in vitro and in vivo studies with wild-type B16-F1 and B16-F1ΔFOXC2 melanomas, we show for the first time that the FOXC2 transcription factor is a critical regulator of melanoma cell growth. The B16-F1ΔFOXC2 melanoma cell line described herein will serve as a useful tool for investigating the function and target genes of FOXC2 in melanoma. Citation Format: Corey J. Williams, Coleman E. Johnson, David Z. Bushhouse, Kristian M. Hargadon. The FOXC2 transcription factor promotes growth of melanoma cells in both in vitro and in vivo settings [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2610.
Virus Linked to Valvulitis, Congenital Defects
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Usefulness of the “AFP model” to predict recurrence tumor in patients transplanted with carcinoma hepatocellular within Milan criteria
Authors: Victor J Beltrán, Maria Luisa Gonzalez Dieguez, Valle Cadahía-Rodrigo, Carmen Álvarez-Navascués, Maria Varela, Carmen Garcia-Bernardo, Ignacio Gonzalez-Pinto, Manuel Rodríguez
Journal: Journal of Hepatology (2020)
Helpful Hate
Authors: Samuel Vaisrub
Journal: JAMA (1979)

Whereas patients have often proclaimed their dislike of physicians, physicians rarely admitted to reciprocating this sentiment. Literature abounds in derisive caricatures of physicians but rarely of patients. An unwritten "law of the hills" sets the patient beyond the pale of ridicule or hatred. The patient belongs to the ranks of suffering humanity that deserves only respect and compassion. The secret, however, is out of the closet. Although conceding that all patients deserve compassion and equal care, physicians no longer conceal from themselves or others the inequality in their emotional attitudes toward the individual patient. They admit that some patients "turn them off."1 Curiously, these patients incur the physician's dislike not because they are bad but because of their behavior as patients. In a recent communication, Groves<sup>1</sup>classifies obnoxious patients under the following four categories: (1) dependent clingers, (2) entitled demanders, (3) manipulative help rejectors, and (4) self-destructive deniers. The
THE REVISED CONSTITUTION AND BY-LAWS.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cases and Observations in Hospital Practice
Authors: R. Chambers
Journal: BMJ (1845)

form as follows :-I pour a small quantity of infusion into a glass, on which is added the oil, and again another small quantity of infusion upon it.In this mnanner the dose may be swallowed, and will slip down without offending the' palate, and generally is well retained even by irritable stomachs.Another mode,has been successful when many have failed, and will be found eqtially valuable: it is the yoke of an: egg beat uip with boiling water and sugar, with which may be mixed a dessert-spoonful of brandy, and on this the dose may be given without producing that nausea so frequently experienced when conveyed by other vehicles. CASES AND OBSERVATIONS IN HOSPITALPRACTICE.By RICHAtD CaAMBDRS, M.D., Physician to the Essex and Colchester Hospital.-(Continued from page 698.)CONGES-I'VE DYSXPEPSIA.CASE 1.-Stephen Wheel, aged 57, a labourer, admitted July 3,-1845, complains of constant pain in the epigastrium, increased-after taking food; suffers also from pain in the loins, and occasionally in the legs; the bowels are confined; the appetite is indifferent; the tongue is covered with a white coat on the dorsum, the sides and edges are florid, the papillae are very prominent; pulse 68; prefers warm drinks; -bhag an anxious melancholy countenance.Was in the Hospital a year ago for a similar attack.
Triazolam.
Authors: J M Jonas
Journal: BMJ (1993)

<h3>Abstract</h3> Somatic mutations in non-coding regions of the genome and even exonic mutations may have unidentified non-coding consequences which are often overlooked in analysis workflows. Here we present RegTools (www.regtools.org), a free, open-source software package designed to integrate analysis of somatic variant calls from genomic data with splice junctions extracted from transcriptomic data to efficiently identify variants that may cause aberrant splicing in tumors. RegTools was applied to over 9,000 tumor samples with both tumor DNA and RNA sequence data. We discovered 235,778 events where a variant significantly increased the splicing of a particular junction, across 158,200 unique variants and 131,212 unique junctions. To further characterize these somatic variants and their associated splice isoforms, we annotated them with the Variant Effect Predictor (VEP), SpliceAI, and Genotype-Tissue Expression (GTEx) junction counts and compared our results to other tools that integrate genomic and transcriptomic data. While variants associated with certain types of alternative splicing events can be identified by the aforementioned tools, the unbiased nature of Regtools has allowed us to identify novel splice variants, including previously unreported patterns of splicing disruption in cancer drivers, such as <i>TP53</i>, <i>CDKN2A</i>, and <i>B2M,</i> and genes not previously reported that could represent novel driver events, such <i>RNF145</i>.
Medical licensure 1972. Statistical review
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract P266: Low Adherence to Antihypertensive Medications Predicts a Decline in Health-Related Quality of Life Among Older Adults
Authors: Erin Peacock, LaKeisha Williams, Cara Joyce, Paul Muntner, Donald Morisky, Marie Krousel-Wood
Journal: Circulation (2017)

Purpose: Low adherence to antihypertensive medication is associated with poor cardiovascular outcomes and increased healthcare costs. Less is known about how low adherence relates to health-related quality of life (HRQOL) over time. We tested whether low adherence to antihypertensive medications predicts a decline in HRQOL over one year using data from the Cohort Study of Medication Adherence among Older Adults (CoSMO). Methods: A telephone survey was administered to hypertensive older adults three times at yearly intervals. Three measures of low adherence captured at first follow-up were used: pharmacy fill (low adherence defined as proportion of days covered (PDC) &lt;0.8), self-report using the 8-item Morisky Medication Adherence Scale (MMAS-8) (low adherence defined as a score &lt;6), and self-report using a published 4-item scale by Krousel-Wood and colleagues (K-Wood-4) (low adherence defined as a score &gt;0). HRQOL was measured using the RAND Medical Outcomes Study 36-item tool. Low HRQOL was defined in two ways: Mental and Physical Component Summary scores (MCS and PCS, respectively) in the lowest tertile. Decline in HRQOL was defined as a 10 point decrease from first to second follow-up. Separate multivariable logistic regression models were used to obtain odds ratios (OR) and 95% confidence intervals (CI) for declines in MCS and PCS, after adjusting for sociodemographic and clinical factors. The analysis predicting a decline in MCS was restricted to those without low MCS at first follow-up (n=1234), while the analysis predicting a decline in PCS was restricted to those without low PCS at first follow-up (n=1225). Results: The sample was 58.2% female and 30.0% black with a mean age of 74.9. Among those without low MCS at first follow-up, the incidence of low MCS at second follow-up was 21.6%; the incidence of low PCS at second follow-up was 15.7% among those without low PCS at first follow-up. After adjusting for sociodemographic and clinical factors, low adherence at first follow-up as measured by the K-Wood-4 was associated with a decline in MCS over one year (OR=1.85, 95% CI 1.13, 3.05), but not with a decline in PCS (OR=0.73, 95% CI 0.47, 1.14). Neither PDC nor MMAS-8 measures predicted declines in MCS or PCS over one year. Conclusions: Low adherence to antihypertensive medication as measured by the K-Wood-4 predicts a decline in MCS, but not PCS, over one year among older adults with hypertension. Efforts to address low adherence may improve HRQOL for older adults.