tbuckley/cabot-search huggingface dataset:
PRINCIPLES UNDERLYING THE TREATMENT OF HEART DISEASE BY EXERCISE
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Length of stay in the intensive care unit. Effects of practice guidelines and feedback
Authors: K. A. Eagle
Journal: JAMA (1990)

We developed consensus management guidelines for patients admitted with chest pain, pulmonary edema, and syncope and used these guidelines to examine practice variation and the effects of physician feedback on decision making in 1145 consecutive admissions to three medical intensive care units. Data collection included a 6-month baseline period and two 6-month physician feedback periods. Hospital length of stay fell from 8.34 days to 7.41 and 7.14 days during feedback; intensive care unit length of stay fell from 2.45 days to 2.23 and 2.07 days. Feedback was associated with an increase in the percentage of patients conforming to the management guidelines. Multiple linear regression showed that feedback correlated with reductions of 0.79 days (confidence interval, 0.12 to 1.46) in hospital length of stay and 0.21 days (confidence interval 0.05 to 0.37) in intensive care unit length of stay. This effect was most apparent in patients not requiring any intervention, but with a major complication. During the 6-month follow-up, mortality, readmission, and urgent readmission rates were similar for patients admitted in baseline and feedback periods. (<i>JAMA</i>. 1990;264:992-997)
Incidence of prostate cancer diagnosis in the eras before and after serum prostate-specific antigen testing
Authors: S. J. Jacobsen
Journal: JAMA (1995)

<h3>Objective.</h3> —To estimate the incidence of prostate cancer in Olmsted County, Minnesota, from 1983 through 1992 to describe the secular changes that have occurred since the introduction of serum prostate-specific antigen (PSA) testing to the community medical practice in 1987. <h3>Design.</h3> —Population-based, descriptive epidemiological study with ecologic and individual level comparisons over time. <h3>Study Setting.</h3> —Olmsted County, Minnesota, where the Rochester Epidemiology Project provides passive surveillance of the population for health outcomes. <h3>Subjects.</h3> —All 511 biopsy-proven incident cases of adenocarcinoma of the prostate diagnosed from 1983 through 1992. The community inpatient and outpatient medical records of all incident cases were reviewed to evaluate the presenting characteristics of men at the time of diagnosis. <h3>Results.</h3> —The age-adjusted incidence of biopsy-proven prostate cancer increased from 64 per 100 000 person-years in 1983 to 215 per 100 000 person-years in 1992. The increase occurred primarily between 1987 and 1988 and was predominately for organ-confined tumors. The age-specific incidence increased dramatically in this same period among men aged 50 years and older. Among men aged 70 years and older, however, prostate carcinoma incidence rates declined after 1990 following the initial increase. This decline among older men contrasted with community-based estimates of PSA utilization rates, which demonstrated consistent increases since 1987 to nearly 50% of the older population in 1992. <h3>Conclusion.</h3> —These results support the premise that the recent increase in prostate cancer is due in part to the increased utilization of serum PSA testing. Further, the increased incidence appears to be a transient phenomenon due to the depletion of previously undiagnosed cases from the prevalence pool. Finally, these data suggest that, in terms of stage at diagnosis, early detection efforts may be effective in identifying more early stage (smaller) cancers. (<i>JAMA</i>. 1995;274:1445-1449)
Incorrect Values.—
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Association Between Tracheal Intubation During Adult In-Hospital Cardiac Arrest and Survival
Authors: Lars W. Andersen, Asger Granfeldt, Clifton W. Callaway, Steven M. Bradley, Jasmeet Soar, Jerry P. Nolan, Tobias Kurth, Michael W. Donnino
Journal: JAMA (2017)

Tracheal intubation is common during adult in-hospital cardiac arrest, but little is known about the association between tracheal intubation and survival in this setting.To determine whether tracheal intubation during adult in-hospital cardiac arrest is associated with survival to hospital discharge.Observational cohort study of adult patients who had an in-hospital cardiac arrest from January 2000 through December 2014 included in the Get With The Guidelines-Resuscitation registry, a US-based multicenter registry of in-hospital cardiac arrest. Patients who had an invasive airway in place at the time of cardiac arrest were excluded. Patients intubated at any given minute (from 0-15 minutes) were matched with patients at risk of being intubated within the same minute (ie, still receiving resuscitation) based on a time-dependent propensity score calculated from multiple patient, event, and hospital characteristics.Tracheal intubation during cardiac arrest.The primary outcome was survival to hospital discharge. Secondary outcomes included return of spontaneous circulation (ROSC) and a good functional outcome. A cerebral performance category score of 1 (mild or no neurological deficit) or 2 (moderate cerebral disability) was considered a good functional outcome.The propensity-matched cohort was selected from 108 079 adult patients at 668 hospitals. The median age was 69 years (interquartile range, 58-79 years), 45 073 patients (42%) were female, and 24 256 patients (22.4%) survived to hospital discharge. Of 71 615 patients (66.3%) who were intubated within the first 15 minutes, 43 314 (60.5%) were matched to a patient not intubated in the same minute. Survival was lower among patients who were intubated compared with those not intubated: 7052 of 43 314 (16.3%) vs 8407 of 43 314 (19.4%), respectively (risk ratio [RR] = 0.84; 95% CI, 0.81-0.87; P < .001). The proportion of patients with ROSC was lower among intubated patients than those not intubated: 25 022 of 43 311 (57.8%) vs 25 685 of 43 310 (59.3%), respectively (RR = 0.97; 95% CI, 0.96-0.99; P < .001). Good functional outcome was also lower among intubated patients than those not intubated: 4439 of 41 868 (10.6%) vs 5672 of 41 733 (13.6%), respectively (RR = 0.78; 95% CI, 0.75-0.81; P < .001). Although differences existed in prespecified subgroup analyses, intubation was not associated with improved outcomes in any subgroup.Among adult patients with in-hospital cardiac arrest, initiation of tracheal intubation within any given minute during the first 15 minutes of resuscitation, compared with no intubation during that minute, was associated with decreased survival to hospital discharge. Although the study design does not eliminate the potential for confounding by indication, these findings do not support early tracheal intubation for adult in-hospital cardiac arrest.
Epidemic rubella in adolescent boys. Clinical features and results of vaccination
Authors: P. J. Landrigan
Journal: JAMA (1974)

Between April 7 and June 10, 1972, there occurred 163 cases of rubella in Olmsted County, Minnesota; 103 of the cases were in adolescent boys. Prior restriction of rubella vaccine to girls approaching puberty produced the uneven distribution of cases; attack rates in unvaccinated male and female adolescents were nearly identical. Vaccine efficacy was 93.5%. During rubella infection, joint pain was noted by 44% of the adolescent boys and by 65% of the adolescent girls. Joint pains or paresthesias following Cendehill rubella vaccination were reported by 8.7% of vaccinated adolescent boys, by 2.3% of those with rubella hemagglutination-inhibition antibodies at the time of inoculation, and by 17.9% of those without antibodies; joint pains or paresthesias were noted by 3.9% of unvaccinated adolescent male control subjects. None of the disorders following vaccination was unusually prolonged or severe.
Commentary
Authors: Lest[ill][ill] S. King
Journal: JAMA (1978)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pro-Forma
Authors: R. M. F. Picken
Journal: BMJ (1955)

<h3>Abstract</h3> Genetic risk factors for autism spectrum disorder (ASD) have yet to be fully elucidated. Postzygotic mosaic mutations (PMMs) have been implicated in several neurodevelopmental disorders and overgrowth syndromes. We systematically evaluated PMMs by leveraging whole-exome sequencing data on a large family-based ASD cohort, the Simons Simplex Collection. We found evidence that 11% of published single nucleotide variant (SNV) <i>de novo</i> mutations are potentially PMMs. We then developed a robust SNV PMM calling approach that leverages complementary callers, logistic regression modeling, and additional heuristics. Using this approach, we recalled SNVs and found that 22% of <i>de novo</i> mutations likely occur as PMMs in children. Unexpectedly, we found a significant burden of synonymous PMMs in probands that are predicted to alter splicing. We found no evidence of missense PMM burden in the full cohort. However, we did observe increased signal for missense PMMs in families without germline mutations in probands, which strengthens in genes intolerant to mutations. We also determined that 7-11% of parental mosaics are transmitted to children. Parental mosaic mutations make up 6.8% of all mutations newly germline in children, which has important implications for recurrence risk. PMMs intersect previously implicated high confidence and other ASD candidate risk genes, further suggesting that this class of mutations contribute to ASD risk. We also identified PMMs in novel candidate risk genes involved with chromatin remodeling or neurodevelopment. We estimate that PMMs contribute risk to 4-8% of simplex ASD cases. Overall, these findings argue for future studies of PMMs in ASD and related-disorders.
Karate injuries.
Authors: E A Nieman, P G Swann
Journal: BMJ (1971)

can we know whether the high pressure we record in the office or outpatient clinic is the patient's "real pressure"?You offer no solution other than admission to hospital.Surely there is a much simpler way-study the electrocardiogram.William Evans' taught that a high blood pressure in a patient with a normal electrocardiogram should be ignored, and subsequent studies have supported this view.Very recently, Sannerstedt et al.2 have reported a close correlation between electrocardiographic evidence of left ventricular hypertrophy and the resting blood pressure and level of systemic vascular resistance.Patients with a raised blood pressure who had a normal electrocar- diogram, had a normal vascular resistance.-Iam, etc.
Canadian Journal of Microbiology, Ottawa
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Factors influencing discrepancies between premortem and postmortem diagnoses
Authors: R. M. Battle
Journal: JAMA (1987)

A study of 2067 autopsies collected from 32 university and community hospitals of various sizes located throughout the United States showed the rate of discrepancies between premortem and postmortem diagnoses to be influenced by the type and size of hospital, the age and sex of the patient, and the disease responsible for the patient's death. Of equivocal or no influence were the length of the terminal hospitalization, the degree of clinical involvement in the case of the person responsible for establishing the discrepancy level, and the autopsy rate, at least as it applies to community hospitals. (<i>JAMA</i>1987:258:339-344)
Abstract 2645: Low Wall Motion Velocity of Left Atrial Appendage Predicts Thrombus Formation Caused by Atrial Appendage Dysfunction in Acute Stroke Patients with Atrial Fibrillation
Authors: Harutoshi Tamura, Osamu Hirono, Hidenobu Okuyama, Satoshi Nishiyama, Tetsuro Shishido, Takehiko Miyashita, Takuya Miyamoto, Joji Nitobe, Tetsu Watanabe, Isao Kubota
Journal: Circulation (2008)

It is well established that transesophageal echocardiography (TEE) is the most useful examination to detect thromboembolic sources in acute stroke patients, in spite of semi-invasive procedure. Transthoracic echocardiography (TTE) is less invasive, whereas it is sometimes difficult to detect thrombus in left atrial appendage (LAA). The aim of this study was to elucidate whether LAA wall motion measured by TTE was useful for detecting LAA thrombus. We performed TTE and TEE in 169 consecutive acute ischemic stroke patients with AF within 7 days after the onset (male, n=117, 71 ± 11 years old; female, n=52, 75 ± 10 years old). LAA wall motion velocity (LAWV) was measured by tissue Doppler imaging at LAA tip from parasternal short axis view of TTE. Patients were prospectively followed-up until primary endpoints such as stroke recurrence or death (mean follow-up period of 362 days). LAWV was significantly lower in patients with LAA thrombus than in those without thrombus (8.1 ± 1.9 vs. 11.6 ± 4.1 cm/s, P&lt;0.01). LAWV was significantly correlated with LAA peak emptying flow velocity (R=0.74, P&lt;0.01). The multivariate logistic regression analysis showed that low LAWV (&lt;9.3 cm/s) was an independent predictor of LAA thrombus formation (odds ratio, 16.45; 95% confidence interval, 4.57–59.25; P&lt;0.01). Stroke recurrence occurred in 24 patients (14%) during follow-up. The Cox multivariate proportional hazard analysis revealed that low LAWV (&lt;9.3 cm/s) was an independent predictor for stroke recurrence (hazard ratio, 5.0; 95% confidence interval, 1.14 –21.74; P&lt;0.05). Kaplan-Meier survival analysis showed that stroke recurrence rates were markedly higher in patients with low LAWV than in those with high LAWV (26% vs. 6%, P&lt;0.01). In conclusion, LAWV successfully detected LAA dysfunction which caused LAA thrombus. Low LAWV may be a non-invasive predictor for stroke recurrence in ischemic stroke patients.
Public Health
Authors: Peter A. Leggat
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fondaparinux in Patients With ST-Segment Elevation Myocardial Infarction—Reply
Authors: Salim Yusuf, Shamir R. Mehta
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cardiac efficiency
Authors: C.L. Gibbs, C.J. Barclay
Journal: Cardiovascular Research (1995)

Journal Article Cardiac efficiency Get access C.L. Gibbs, C.L. Gibbs Department of Physiology, Monash University, Clayton, Vic. 3168, Australia Search for other works by this author on: Oxford Academic PubMed Google Scholar C.J. Barclay C.J. Barclay Department of Physiology, Monash University, Clayton, Vic. 3168, Australia Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 30, Issue 5, November 1995, Pages 627–634, https://doi.org/10.1016/S0008-6363(95)00161-1 Published: 01 November 1995 Article history Received: 01 May 1995 Accepted: 10 August 1995 Published: 01 November 1995
Clinical genodermatology.
Authors: Theodore Cornbleet
Journal: JAMA (1963)

Our present era will doubtlessly be known as the atomic age; yet a number of other significant and fruitful activities could just as well characterize our times. One of these is the burst of interest in and the increase of our knowledge of hereditary mechanisms, materials, and patterns. There is always lag between development of basic information and its practical applications in the clinic. Nevertheless, we find already an increasing stream of literature on the subject of heredity in answer to clinicians' demands and interest. A particularly happy product in this flow, directed toward the practicing physician, is the volume. Butterworth is well known among dermatologists for his continued interest in and delineation of the genodermatoses. Working in an institution which harbors hundreds of patients with various congenital anomalies, he has been like a sagacious museum director ministering to his charges for their benefit and the enlightenment of the outer
"Bioregulators Come of Age in the Control of Tumor Growth and Metastasis"
Authors: G.L. Nicolson
Journal: JNCI Journal of the National Cancer Institute (1996)

The correct address for correspondence is Garth L. Nicolson, Ph.D., Department of Tumor Biology (Box 108), The university of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030.