tbuckley/cabot-search huggingface dataset:
RELATION OF CONTACT WITH TUBERCLE BACILLUS TO DEVELOPMENT OF TUBERCULOSIS IN ADULTS
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Variations in Resource Utilization Among Medical Specialties and Systems of Care
Authors: R. L. Kravitz
Journal: Annual Review of Public Health (1995)

As sweeping changes in the organization and delivery of health care are implemented, it is important to examine the relationship between various types of cost-containment efforts, health care costs, and quality of care. This article reviews the evidence that physician specialty training, the organization of physicians, and the method of physician payment are significant influences upon the utilization of health care services. Data from before the late 1980s raised the possibility that family practitioners employed fewer resources than general internists and that health maintenance organizations used fewer resources than solo practitioners. However, the studies from which these data were derived were marred by insufficient attention to patient mix, failure to account for interactions between specialty and system, and inadequate regard for the complexities of modern practice structures. More recent data from the Medical Outcomes Study (MOS) overcomes some but not all of these problems. In general, it can be safely concluded that primary care specialty training, group practice, and prepaid care are associated with less utilization. Nevertheless, much more research is needed to address remaining methodologic problems and to obtain data that are generalizable to the wide array of modern practice settings.
Epididymitis in prepuberal boys. Presenting manifestation of vesicoureteral reflux
Authors: A. D. Amar
Journal: JAMA (1969)

Acute epididymitis in prepuberal boys is rare; when it does occur, it may be the first manifestation of urologic anomaly or disease. After the diagnosis of epididymitis is established, urologic investigation is essential. In the three boys described here, epididymitis heralded vesicoureteral reflux, which in turn was associated with major abnormalities of the urinary tract.
THE PHYSICIAN AS A CITIZEN
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A phase I study of vorinostat (suberoylanilide hydroxamic acid) in combination with 5-fluorouracil, leucovorin, and oxaliplatin (FOLFOX) in patients with advanced colorectal cancer (CRC)
Authors: M. G. Fakih, L. Pendyala, P. Smith, P. Creaven, K. Toth, J. Zwiebel, S. Frankel, A. Litwin, L. Huffman, M. Egorin
Journal: Journal of Clinical Oncology (2007)

4088 Background: At 5μM, vorinostat decreases thymidilate synthase (TS) expression by ∼ 40 fold, which translates into synergistic antitumor activity when added to 5-FU. We conducted a phase I study of vorinostat plus FOLFOX in patients with CRC to determine the recommended dose of this combination. Methods: Vorinostat was escalated in a standard 3+3 design with a planned expansion of the maximum tolerated dose (MTD) cohort to 10 patients (pts). Vorinostat (100mg, 200mg, 300mg, 400 mg dose levels) was given twice daily for 1 week followed by 1 week break. FOLFOX was administered at a fixed standard dose every 2 weeks on the 4 th day of vorinostat. Tumor biopsies were obtained from liver metastases before and on the 4 th day of vorinostat (prior to FOLFOX) to assess TS expression. Results: 19 pts were treated on study (M/F: 12/7; median age: 58; ECOG 0/1: 6/13). All pts had failed prior FOLFOX therapy. Dose-limiting toxicities (DLT) were noted in 3 pts: 2/4 pts at dose level (DL)4 (vorinostat 400mg BID) consisting of grade (G) 3 fatigue, &amp; diarrhea in 1 pt and G3 fatigue in the other; 1/8 pts at DL3 (MTD, vorinostat 300mg BID) consisting of G3 fatigue, anorexia, nausea, and dehydration. 8 pts have been treated at the MTD for a total of 38 cycles. “All Cycles” G3–4 toxicities at the MTD consisted of 2 pts with G3 neutropenia and 2 pts with G3 thrombocytopenia along with the above described DLT. Responses were evaluable in 17 pts: 0 Objective Response, 8 Stable Disease (4 confirmed). TS expression by IHC and by RT-PCR showed modest decreases in 2/6 patients after vorinostat treatment. Cmax of SAHA was &lt; 2μM at all investigated DL, which could explain the lack of adequate TS down-regulation. Conclusions: vorinostat 300mg PO BID × 1 week every 2 weeks in combination with FOLFOX is the established recommended dose. The lack of significant TS down-regulation may be due to the suboptimal serum vorinostat concentrations. Alternate shorter vorinostat schedules may allow for further daily dose escalations and hence for better likelihood of TS down-regulation. This study was partly supported by CTEP, NCI. No significant financial relationships to disclose.
DNA Adduct Formation in the Human Nasal Mucosa as a Biomarker of Exposure to Environmental Mutagens and Carcinogens
Authors: Sylwia Flato, Kari Hemminki, Eva Thunberg, Antonis Georgellis
Journal: Environmental Health Perspectives (1996)

Human exposure to chemical compounds, often termed xenobiotics, has been linked to a number of enhanced incidences of various neoplasias.A majority of these enter the human body through inhalation.Most xenobiotics are metabolized in the body to more hydrophilic metabolites before excretion in the urine and bile.During this process, promutagens and procarcinogens could be activated and could interact with proteins as well as DNA to form adducts.DNA adducts formed by chemical carcinogens can, therefore, be used as biomarkers of exposure and other host factors.This study shows that DNA adduct analysis can be performed on cells from human nasal mucosa.Using the nasal lavage procedure performed on 20 healthy volunteers, 5 x 105 to 5 x 106 cells were obtained from which 5 to 40 pg DNA was isolated.DNA adducts were analyzed by the 32P-postlabeling assay.The DNA adduct levels ranged between 1.4 and 6 adducts/1 06 nucleotides.In addition to its simplicity, the nasal lavage procedure is an inexpensive, noninvasive procedure that requires no anesthetics or special equipment.Moreover, the cells obtained are the first to come in contact with air pollutants.DNA adduct analysis from human nose mucosa cells could therefore be used to develop a technique suitable for the assessment of exposure to chemical carcinogens through inhalation.
Probable Locally Acquired Mosquito-Transmitted Plasmodium vivax Infection—Georgia, 1996
Journal: JAMA (1997)

Endemic, mosquitoborne transmission of malaria was interrupted in the United States during the 1940s. Since then, 57 small localized outbreaks of probable mosquito-transmitted malaria in the United States have been reported to CDC. This report summarizes the investigation of a case of Plasmodium vivax infection in a resident of Georgia who had never lived in or visited a malarious area. The results of this investigation suggest that this case probably was acquired through the bite of a locally infected Anopheles sp. mosquito, although a probable source of infection for mosquitoes was not confirmed.
BRONCHOSCOPY IN THE NEWBORN
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
FIBROSIS IN TUBERCULOSIS
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
INDICATIONS FOR OPENING THE DRUM IN ACUTE MIDDLE EAR INFECTIONS
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Occupational cancer in Spain
Authors: C A González, A Agudo
Journal: Environmental Health Perspectives (1999)

The knowledge of specific problems of occupational cancer in Spain is scarce.The environment of the workplace has improved over the last few years after a long period distinguished by bad working conditions, incomplete legislation, and insufficient safety measures and control.It has been estimated that 3,083,479 workers (25.4% of employees) were exposed to carcinogens.The most common occupational exposures to carcinogenic agents were solar radiation, environmental tobacco smoke, silica, and wood dust.The highest number of employees were exposed to silica crystalline (404,729), diesel engine exhaust (274,321), rubber products (99,804), benzene (89,932), ethylene dibromide (81,336), agents used in furniture and cabinet making (72,068), and formaldehyde (71,189).The percentage of total cancer deaths attributed to occupational exposure was 4% (6% in men, 0.9% in women).Compared with other European countries, the incidence of lung cancer and leukemia in Spain are one of the lowest, but it is rapidly increasing.The incidence of urinary bladder and larynx cancer, on the contrary, are one of the highest.Few studies on occupational cancer have been conducted in Spain.The main problems are the availability of death certificates and the quality of the information on occupation in mortality of statistics.It is necessary to improve methods of assessment of exposures using expert hygienists and biologic markers of exposure and diseases.Reduction of cancer by limiting or avoiding exposure to known occupational carcinogens is still necessary.
The Gulstonian Lectures on Epilepsy
Authors: W. R. Gowers
Journal: BMJ (1880)

PRESIDENT AND GENTLEMEN,-The founder of the lectures, the delivery of which for the present year I have the honour of commencing to-day, left certain directions regarding their method and scope, doubt- less well known to you.The progress -of medical science has, however, 'rendered strict adherence to those directions scarcely practic'able.Two or more diseases were to be discusssd, and a body if possible dissected in illustration of them.But the time is long past since the demonstra- tion of a chance' " subject" could afford instruction to the Fellows and Members of this College; while our study of' disease-has become so elaborate that, in the space of three hours, ft is-iimpossible to consider more than a few points regarding any one disease, May we niot read " be- tween the lines" of the founder's direction the anticipation that the progress of pathological anatomy would speedily reveal the organic basis of all diseases ?Such an anticipation may, when the words were written, have been not unreasonable.
Updated Results of a Phase 1/2a, Dose Escalation Study of Pvx-410 Multi-Peptide Cancer Vaccine in Patients with Smoldering Multiple Myeloma (SMM)
Authors: Ajay K. Nooka, Michael Wang, Andrew J. Yee, Sheeba K. Thomas, Elizabeth K. O'Donnell, Jatin J. Shah, Jonathan L. Kaufman, Sagar Lonial, Paul G. Richardson, Noopur S. Raje
Journal: Blood (2015)
Progress in medical information management. Systematized nomenclature of medicine (SNOMED)
Authors: R. A. Cote
Journal: JAMA (1980)

THE LAST 50 years have witnessed an explosion in the scientific advances available to the medical practitioner in his evaluation and treatment of the patient. The arrival of computer technology has helped to augment the physician's recall of myriad pieces of information to help him evaluate the data for diagnosis and treatment. Inherent in this process is the need for medicine to develop a standardized language for the classification of disease into general groups, as well as detailed schemas for the naming of signs, symptoms, diseases, and procedures. To be useful, the system needs to be completely integrated. We review the historical development of classifications for statistical purposes and the conceptual evolution of nomenclatures and discuss the new nomenclature-classification system called the<i>Systematized Nomenclature of Medicine (SNOMED)</i>.<sup>1</sup>Present and future requirements of the management of medical information will be presented, including SNOMED applications. <h3>PART I</h3><h3>STATISTICAL MANAGEMENT: CLASSIFICATION VS</h3>
Essentials of Gynecologic Endocrinology [with Sections on the Male]
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Prospective Study On Drug Monitoring Of Pegasparaginase and Erwinia Asparaginase and Asparaginase Antibodies In Pediatric Acute Lymphoblastic Leukemia
Authors: Wing H. Tong, Rob Pieters, Gertjan Kaspers, Maroeska D.W.M. te Loo, Marc Bierings, Cor van den Bos, Wouter J.W. Kollen, Wim C.J. Hop, Joachim Boos, Mary V. Relling, Hans Juergen Kuehnel, Wim J Tissing, Inge M. van der Sluis
Journal: Blood (2013)
dark river
Authors: D.A. Frater
Journal: Annals of Internal Medicine (2018)

Ad Libitum21 August 2018dark riverD.A. Frater, MDD.A. Frater, MDDallas, Texas (D.F.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M18-0885 Audio Reading - “dark river” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "dark river," by D.A. Frater. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Did you smile when you saw her baptize the infant son of Myrmidonhead first from the shore across the way? And who heard as woodrubbed wood between the soft splashes of your gondolier's pole,each push through the water bleeding back like oil, metalkissing metal as you pocketed your dry-mouthed tolls?You reek of sulfur, foul fumaroles hissing pent-upanger upon you. Your gaze defies the shadows underthat long black hood. He has drawn you fierce, eyes flashing lost shadesof blue, as you beat back the reaching hands, their idealreflections floating free above the burnt, undrowning souls.Would you believe I had ... Author, Article, and Disclosure InformationAffiliations: Dallas, Texas (D.F.)Current Author Address: D.A. Frater, MD; e-mail, [email protected]md. PreviousarticleNextarticle Advertisement Audio Reading - “dark river” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "dark river," by D.A. Frater. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 21 August 2018Volume 169, Issue 4Page: 263KeywordsHeart rateHemorrhageInfantsIntensive care unitsMotivationNursesOilsRiversSpineStroke ePublished: 21 August 2018 Issue Published: 21 August 2018 Copyright & PermissionsCopyright © 2018 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Connecting the Dots
Authors: Raphael P. Rush, Alexandra P. Saltman, Anca A. Prica, Ari Breiner, Allan S. Detsky
Journal: New England Journal of Medicine (2017)

A 46-year-old woman presented to the emergency department with limb weakness. In the preceding 3 months, back pain, hip flexor weakness, and numbness of a finger had developed, followed by weakness and shooting pains in her limbs and weakness in facial muscles.
Phase I study of the effects of renal impairment on the pharmacokinetic (PK) and safety of satraplatin in patients (Pts) with refractory non-hematologic cancer
Authors: D. S. Hong, M. Galsky, E. Chiorean, D. Mulkerian, D. Greene, F. E. Nathan, M. Petrone, L. H. Camacho
Journal: Journal of Clinical Oncology (2006)

2044 Background: Satraplatin (S) is a novel oral platinum analog with demonstrated activity in the treatment of pts with platinum-sensitive malignancies. A worldwide, double-blind, placebo-controlled randomized trial evaluating S as 2 nd line therapy for hormone refractory prostate cancer (HRPC) has recently completed enrollment. The current study wasis designed to understand the effect of varying degrees of renal impairiment on the safety and PK of satraplatin. Methods: The study includes 4 levels of renal dysfunction, and 8 pts/cohort: Group 1 (G1) = Normal Renal Controls; G2 = Mild renal impairment (CrCl 50–80 mL/min); G3 = Mod. impairment (CrCl 30-&lt;50 ml/min); G4 = Severe impairment (CrCl &lt;30 mL/min). S was administered orally at 80mg/m 2 /d on d1–5 every 35 days. Results: 21 pts (of a planned total of 32) have been enrolled (13M/8F), median age 63 (range 45–72). Tumor types: Bladder (6), Renal (3), Breast (2), Prostate (2), Colon (2), Other (6). Among 15 evaluable pts, the cohort distribution is G1: 6 pts, G2: 4, G3: 4, and G4: 1. Twenty-six cycles of S have been delivered, and 11 pts have completed at least 2 cycles of therapy. Hematologic toxicities during the first 2 cycles include grade (G) 3/4 neutropenia (0 pts), G 3/4 thrombocytopenia (1), and G 3/4 anemia (1). No significant cardiac, renal, hepatic, or neurologic toxicity has been observed. Nausea, vomiting, and diarrhea were mild to moderate, and controlled with oral therapy. Of 4 pts with evaluable disease, 1 has stable disease, and 3 have progressed. Conclusions: S is well tolerated in pts with varying degrees of renal dysfunction. Updated safety and PK data will be presented at the meeting. [Table: see text]