tbuckley/cabot-search huggingface dataset:
Adjuvant chemotherapy with temozolomide and pegylated liposomal doxorubicin in the first-line therapy of patients with glioblastoma -a phase-II trial
Authors: P. Hau, T. Jauch, B. Hirschmann, E. Drechsel, O. Grauer, H. Koch, C. Wismeth, A. Steinbrecher, U. Bogdahn
Journal: Journal of Clinical Oncology (2004)

1547 Background: Temozolomide (Temodar) recently showed promising results in the first-line therapy of glioblastoma (Stupp R, 2002). Pegylated liposomal doxorubicin PLD (Caelyx/Doxil) was successfully evaluated in patients with recurrent high-grade glioma (Fabel K, 2001; Hau P, 2002). Therefore, a combination of both agents seems promising. Here, we update data on a pilot phase II-trial using this regimen. Methods: We initiated a combination regimen consisting of temozolomide (TMZ) and PLD in the first-line therapy of patients with glioblastoma. TMZ is given during standard radiotherapy (initiation) and on days 1–5 in 28 days starting 4 weeks after completion of radiotherapy (maintainance). PLD is given as a short-time infusion in a dose-escalation regimen once prior to radiotherapy (initiation) and on days 1 and 15 starting 4 weeks after completion of radiotherapy (maintainance). PLD is escalated for 5mg/m2 in groups of three patients with a highest dose of 20mg/m2 (group 4). Primary end point is tumor progression. Results: In the first treatment group using the standard dose of TMZ and 5mg/m2 of PLD, only one out of 7 evaluable patients had a dose limiting toxicity (DLT). In the second treatment group using 10mg/m2 of PLD, the regimen was tolerated without DLT. Concerning efficacy in the
Outcome of lung cancer patients requiring mechanical ventilation for pulmonary failure
Authors: M. S. Ewer
Journal: JAMA (1986)

The prognosis of lung cancer patients who are not candidates for surgery is usually poor. The unfavorable natural history of respiratory failure in this group of patients has been suggested as a causative factor. We analyzed the outcome of 46 consecutive patients with primary lung cancer on whom mechanical ventilators were utilized. Although seven patients were ultimately weaned and survived for at least 24 hours, three of them subsequently died prior to discharge from the hospital. The remaining 39 patients died while using the ventilator. Patient age, tumor cell type, and the etiology of respiratory failure were not significantly different between the weaned and unweaned populations. A difference was noted in the duration of mechanical ventilation: none of the patients who could be weaned required mechanical ventilation for more than six days (range, two to six days). Respiratory failure in the nonsurgical lung cancer patient carries a poor prognosis, and selection of patients for mechanical ventilation should be conservative. (<i>JAMA</i>1986;256:3364-3366)
SOCIETY PROCEEDINGS.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
As better training and machines improve safety, speed becomes focus of newest anesthetic drugs
Authors: M. F. Goldsmith
Journal: JAMA (1992)

TELEVISION, which has been held to account for so many ills of modern society, has at least one undeniable good to its credit. According to Ellison C. Pierce, Jr, MD, chair of the Anesthesia Patient Safety Foundation of the ASA, it was an ABC-TV "20/20" program in 1982 that set in motion "the present decade of real interest and work on patient safety." The program "detailed in a significant manner some pretty bad anesthetic deaths across the country," says Pierce, sparking a call for practice reform. Shortly after viewing that documentary, he became president of the ASA and established a committee on patient safety and risk management that has been very active ever since. <h3>More to Story</h3> Success in making safe a procedure with all the inherent risks of anesthesia has been ascribed by many to recent technological advances—but not by Pierce, who has been in practice for 35 years.
Medical Organization
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Screening for Colorectal Cancer
Authors: Ayokunle T. Abegunde
Journal: Annals of Internal Medicine (2012)

Letters7 August 2012Screening for Colorectal CancerAyokunle T. Abegunde, MBBS, MSc, DTM&HAyokunle T. Abegunde, MBBS, MSc, DTM&HFrom John H. Stroger Jr. Hospital of Cook County, Chicago, IL, 60612.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-157-3-201208070-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The evidence supporting the effectiveness of early screening of African Americans at average risk for colorectal cancer (CRC) is scarce. It is surprising that the American College of Physicians' (ACP) guidance statement (1) recommends CRC screening in this group at age 40 years when there is no evidence that such a strategy is effective. A recent article from Gupta and colleagues (2) reported that increasing colonoscopy participation by 5% and 10% among African Americans aged 50 years or older detected 53% and 57% of CRC, respectively, and early screening of African Americans at age 45 years detected ...References1. Qaseem A, Denberg TD, Hopkins RH, Humphrey LL, Levine J, Sweet DE, et al; Clinical Guidelines Committee of the American College of Physicians. Screening for colorectal cancer: a guidance statement from the American College of Physicians. Ann Intern Med. 2012;156:378-86. [PMID: 22393133] LinkGoogle Scholar2. Gupta S, Shah J, Balasubramanian BA. Strategies for reducing colorectal cancer among blacks. Arch Intern Med. 2012;172:182-4. [PMID: 22271128] CrossrefMedlineGoogle Scholar3. You YN, Xing Y, Feig BW, Chang GJ, Cormier JN. Young-onset colorectal cancer: is it time to pay attention? [Letter]. Arch Intern Med. 2012;172:287-9. [PMID: 22157065] CrossrefMedlineGoogle Scholar4. O'Keefe SJ, Chung D, Mahmoud N, Sepulveda AR, Manafe M, Arch J, et al. Why do African Americans get more colon cancer than Native Africans? J Nutr. 2007;137:175S-182S. [PMID: 17182822] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From John H. Stroger Jr. Hospital of Cook County, Chicago, IL, 60612.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoScreening for Colorectal Cancer: A Guidance Statement From the American College of Physicians Amir Qaseem , Thomas D. Denberg , Robert H. Hopkins Jr. , Linda L. Humphrey , Joel Levine , Donna E. Sweet , Paul Shekelle , and Screening for Colorectal Cancer David L. Keller Screening for Colorectal Cancer Tazia K. Stagg Screening for Colorectal Cancer Thomas D. Denberg , Linda L. Humphrey , Paul Shekelle , and Amir Qaseem Metrics 7 August 2012Volume 157, Issue 3Page: 217KeywordsBiomarkersCancer screeningColonoscopyColorectal cancerConflicts of interestGeneticsGenomicsHealth careYoung adults ePublished: 7 August 2012 Issue Published: 7 August 2012 Copyright & PermissionsCopyright © 2012 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Baseline gut microbiota predicts clinical response and colitis in metastatic melanoma patients treated with ipilimumab
Authors: N. Chaput, P. Lepage, C. Coutzac, E. Soularue, K. Le Roux, C. Monot, L. Boselli, E. Routier, L. Cassard, M. Collins, T. Vaysse, L. Marthey, A. Eggermont, V. Asvatourian, E. Lanoy, C. Mateus, C. Robert, F. Carbonnel
Journal: Annals of Oncology (2019)

Ann Oncol 2017; 28(6): 1368–1379 (doi: 10.1093/annonc/mdx108) In the original article, there were errors in Figure 3B and the accompanying legend. These have been corrected online as below. Baseline gut microbiota predicts clinical response and colitis in metastatic melanoma patients treated with ipilimumabAnnals of OncologyVol. 28Issue 6PreviewIpilimumab, an immune checkpoint inhibitor targeting CTLA-4, prolongs survival in a subset of patients with metastatic melanoma (MM) but can induce immune-related adverse events, including enterocolitis. We hypothesized that baseline gut microbiota could predict ipilimumab anti-tumor response and/or intestinal toxicity. Full-Text PDF Open Archive
Report of the Board of Trustees
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Inhibition of apoptosis improves outcome in a model of congenital muscular dystrophy
Authors: Mahasweta Girgenrath, Janice A. Dominov, Christine A. Kostek, Jeffrey Boone Miller
Journal: Journal of Clinical Investigation (2004)

The most common form of human congenital muscular dystrophy (CMD) is caused by mutations in the laminin-α2 gene. Loss of laminin-α2 function in this autosomal recessive type 1A form of CMD results in neuromuscular dysfunction and, often, early death. Laminin-α2–deficient skeletal muscles in both humans and mice show signs of muscle cell death by apoptosis. To examine the significance of apoptosis in CMD1A pathogenesis, we determined whether pathogenesis in laminin-α2–deficient (Lama2–/–) mice could be ameliorated by inhibiting apoptosis through either (a) inactivation of the proapoptosis protein Bax or (b) overexpression of the antiapoptosis protein Bcl-2 from a muscle-specific transgene. We found that both of these genetic interventions produced a several-fold increase in the lifespan of Lama2–/– mice. Bax inactivation also improved postnatal growth rate and myofiber histology and decreased fixed contractures of Lama2–/– mice. Thus, Bcl-2 family–mediated apoptosis contributes significantly to pathogenesis in the mouse model of CMD1A, and antiapoptosis therapy may be a possible route to amelioration of neuromuscular dysfunction due to laminin-α2 deficiency in humans.
THE FUNCTIONS OF THE SKIN
Authors: M. S. PEMBREY
Journal: British Journal of Dermatology (1910)

Journal Article THE FUNCTIONS OF THE SKIN Get access M. S. PEMBREY, M.A., M.D. M. S. PEMBREY, M.A., M.D. Lecturer in Physiology, Guy's Hospital Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 22, Issue 12, 1 December 1910, Pages 375–381, https://doi.org/10.1111/j.1365-2133.1910.tb16603.x Published: 01 December 1910
Emergency!
Authors: David Howell, Richard Marshall, Hugh Montgomery, Neil Goldsack
Journal: BMJ (2000)

In the final part of our series David Howell, Richard Marshall, Hugh Montgomery, and Neil Goldsack explain how to manage elderly breathless patients A breathless elderly patient will undoubtedly be one of the commonest emergencies that you are called to as a house officer. The aetiology behind this presentation is often diverse. One of the big problems with treating elderly breathless patients is that they often display multiple pathologies. Therefore, if you are called to see an elderly patient who is breathless and has multiple pathologies the same principles outlined in all the previous articles apply.
Autoimmune Hepatitis
Authors: Edward L Krawitt
Journal: New England Journal of Medicine (2006)

Autoimmune hepatitis is a generally progressive, sometimes fluctuating chronic hepatitis of unknown cause that occurs in children and adults of all ages. It is important to distinguish autoimmune hepatitis from other forms of chronic hepatitis, because a high percentage of cases respond to antiinflammatory or immunosuppressive therapy, or both. Appropriate management can prolong survival, improve quality of life, and avoid liver transplantation. This review discusses the pathogenesis, diagnosis, and treatment of this important form of hepatitis.
American Journal of Gastroenterology, New York
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A PERSONAL APPRECIATION OF SIR WILLIAM OSLER
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Expression of CD10 by Human T Cells That Undergo Apoptosis Both In Vitro and In Vivo
Authors: Giovanna Cutrona, Nicolò Leanza, Massimo Ulivi, Giovanni Melioli, Vito L. Burgio, Giovanni Mazzarello, Giovanni Gabutti, Silvio Roncella, Manlio Ferrarini
Journal: Blood (1999)
Error in Introduction
Authors: William Lowe, Denise Scholtens, Boyd Metzger
Journal: JAMA (2019)

used may no longer meet diagnostic criteria on subsequent testing (or conversely be reassigned from normal to having gestational diabetes).Childhood overweight and obesity is defined by body mass index (BMI); however, BMI in the overweight range sometimes reflects high lean body mass more than adiposity and thus is an imprecise measure of adiposity.Nevertheless, since height and weight are routine clinical measures, BMI z score is typically used clinically as an index of adiposity.The BMIbased childhood overweight and obesity cutoffs 2 were therefore used to power our study.We concur that the nonsignificant fully adjusted odds ratio of 1.21 (95% CI, 1.00-1.46)for the association between gestational diabetes and childhood overweight and obesity may have been related to not meeting our recruitment target.Anticipating the potential limitation of the overweight and obesity outcome and noting the importance of fully addressing contextual factors when drawing scientific conclusions using measures of statistical significance, 3 the HAPO Follow-up Study specified a priori 4 additional secondary measures of childhood adiposity as part of the study design (Table 4 in the article).These included (1) obesity as defined by BMI, (2) percentage of body fat determined by air displacement plethysmography, (3) sum of skinfolds, and (4) waist circumference.In contrast to the overweight and obesity outcome, these 4 outcomes were all significantly associated with gestational diabetes in a fully adjusted model that included maternal BMI.Arguably, the association of gestational diabetes with these more specific measures of childhood adiposity may be as important as the nonsignificant association of gestational diabetes with overweight and obesity.When considered together, our results suggest an association between gestational diabetes as defined by IADPSG criteria and later childhood obesity and adiposity.Requiring more stringent criteria to identify gestational diabetes would narrow the application of the results to primary prevention efforts and diminish the public health implications.
Nitrate Contamination of Drinking Water: Relationship with HPRT Variant Frequency in Lymphocyte DNA and Urinary Excretion of N-Nitrosamines
Authors: Jan M. S. van Maanen, Irene J. Welle, Geja Hageman, Jan W. Dallinga, Paul L. J. M. Mertens, Jos C. S. Kleinjans
Journal: Environmental Health Perspectives (1996)

We studied peripheral lymphocyte HPRT variant frequency and endogenous nitrosation in human populations exposed to various nitrate levels in their drinking water. Four test populations of women volunteers were compared. Low and medium tap water nitrate exposure groups (14 and 21 subjects) were using public water supplies with nitrate levels of 0.02 and 17.5 mg/l, respectively. Medium and high well water nitrate exposure groups (6 and 9 subjects) were using private water wells with mean nitrate levels of 25 and 135 mg/l, respectively. Higher nitrate intake by drinking water consumption resulted in a dose-dependent increase in 24-hr urinary nitrate excretion and in increased salivary nitrate and nitrite levels. The mean log variant frequency of peripheral lymphocytes was significantly higher in the medium well water exposure group than in the low and medium tap water exposure groups. An inverse correlation between peripheral lymphocyte labeling index and nitrate concentration of drinking water was observed. Analysis of N-nitrosamine in the urine of 22 subjects by gas chromatography-mass spectrometry revealed the presence of N-nitrosopyrrolidine in 18 subjects. Analysis of the mutagenicity of well water samples showed that a small number of the well water samples were mutagenic in the Ames Salmonella typhimurium test after concentration over XAD-2 resin. In conclusion, consumption of drinking water, especially well water, with high nitrate levels can imply a genotoxic risk for humans as indicated by increased HPRT variant frequencies and by endogenous formation of carcinogenic N-nitroso compounds from nitrate-derived nitrite.
Glomerular hyperfiltration indicates early target organ damage in essential hypertension
Authors: R. E. Schmieder
Journal: JAMA (1990)

In 111 patients with essential hypertension (World Health Organization stage I or II), we examined the relationship between renal hemodynamics and left ventricular hypertrophy. Left ventricular structure was determined by two-dimensional guided M-mode echocardiography, renal blood flow by iodine I 131 aminohippuric acid clearance, and glomerular filtration rate by creatinine clearance. The glomerular filtration rate correlated with left ventricular mass (<i>r</i>=.52) and left ventricular cross-sectional area (<i>r</i>=.21). Conversely, at a similar age, body mass index, body surface area, and arterial pressure, hypertensive patients with left ventricular hypertrophy disclosed a higher glomerular filtration rate and filtration fraction than those without left ventricular hypertrophy, whereas renal blood flow and renal vascular resistance measurements were not significantly different. Thus, at similar levels of arterial pressure and renal blood flow, glomerular hyperfiltration was linked to early cardiac structural changes in essential hypertension. We conclude that, in a hypertensive patient with normal renal function, a high glomerular filtration rate may be an indicator for early target organ damage in essential hypertension. (<i>JAMA</i>. 1990;264:2775-2780)