tbuckley/cabot-search huggingface dataset:
Informed Consent
Authors: Thomas J. O'Donnell
Journal: JAMA (1974)

In the current issue of the<i>Archives of General Psychiatry</i>(30:129-135, 1974) Romano writes on the always elusive concept of informed consent in clinical research and again suggests the still unresolved ethical question: how informed is informed consent? His research project deals with children at risk for schizophrenia and their parents, and while he does not list exactly what the project involves, he makes it clear that it does not include the risks of pharmacological liabilities (either in the administration or withholding of drugs) or surgical invasions, but rather such minimal risk procedures as observations, questions, and suggestions involving perhaps inconvenience and psychic discomfort, and the risks of invaded confidentiality, albeit in an appropriately protected context. While Romano recognizes the vulnerability of confidential information in a research setting, including it under the notion of risk and seeking appropriate methods of getting informed consent, his main concern seems to be the
MEDICAL TEACHERS AND TEACHING.
Journal: JAMA (1892)

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Der Wasserversuch als Nierenfunktionsprüfung: Eine Zusammenfassung für den Kliniker und praktischen Arzt.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Scoliosis management now subject of numerous questions
Authors: T. Ziporyn
Journal: JAMA (1985)

"Many of you probably thought you'd seen the end of scoliosis," G. Dean MacEwen, MD, of Wilmington, Del, told a roomful of orthopedic surgeons earlier this year. "But today, with school screening sending patients with mild curves into our offices, and patients treated years earlier now turning up as adults, requesting—and in some cases requiring— treatment, all of us have to be to some degree involved in the subject." In fact, however, revived debate at a meeting of the American Academy of Orthopaedic Surgeons in Las Vegas indicates that, for scoliosis, problems supposedly solved by medical science have once again become a mystery. Controversy rages on almost every aspect of scoliosis management. Questions now being asked include: Is scoliosis really a dangerous medical problem? If so, do its chief dangers or complications involve pain, respiratory compromise, or cosmesis? If not, can bracing or surgery be justified? Do curves continue
Long-term treatment of hyperlipidemic patients with clofibrate
Authors: D. Berkowitz
Journal: JAMA (1971)

In 50 hyperlipidemic patients who responded to clofibrate during a three-month trial period, the medication was continued for six to eight years. Eight of the subjects had essential hypercholesterolemia. The remainder had elevations of both the cholesterol and triglyceride levels. Normalization of the serum cholesterol level occurred in each patient and was maintained throughout the entire treatment period. Each of the 42 subjects with hypertriglyceridemia had at least a 25% reduction in those levels; normal values resulted in 38. A reduction in the serum uric acid level and improvement in oral glucose tolerance was also produced in more than 65% of those in whom these were abnormal initially. No evidence of clinical toxic reactions was present in any case.
Update: Syringe Exchange Programs—United States, 1998
Journal: JAMA (2001)

Syringe exchange programs (SEPs) provide sterile syringes in exchange for used syringes to reduce the transmission of human immunodeficiency virus (HIV) and other bloodborne infections associated with the reuse of potentially blood-contaminatedsyringes among injection drug users (IDUs) (1). This report summarizes a survey of 1998 SEP activities in the United States and compares them with 1994-1997 SEP activity surveys (1-3). SEPs are an increasingly common HIV prevention approach that offer a range of public health services in addition to syringe exchange.
Bioaccumulation of Cadmium in Marine Organisms
Authors: John M. Frazier
Journal: Environmental Health Perspectives (1979)

A general review of cadmium concentrations in marine organisms and studies of cadmium bioaccumulation is presented. Factors which influence cadmium concentrations, such as regional differences, seasonal fluctuations and salinity, are discussed and species which are likely to accumulate cadmium identified. Experimental studies designed to investigate the influence of some of these factors on cadmium bioaccumulation in a filter feeding bivalve mollusk, the American oyster (Crassostrea virginica), are presented. Field studies of seasonal dynamics of cadmium in oysters indicate patterns which may be correlated with seasonal physiological activity. The bioaccumulation of cadmium following input to estuarine systems by natural phenomena is observed. Cadmium concentrations in oysters collected from regions of different salinity suggest an inverse relationship between cadmium concentration and salinity. Laboratory experiments designed to investigate mechanisms of cadmium accumulation demonstrate that an inducible cadmium binding protein, similar to metallothiomein, is present in the American oyster.
Fat Transport in Lipoproteins — An Integrated Approach to Mechanisms and Disorders
Authors: Donald S. Fredrickson, Robert I. Levy, Robert S. Lees
Journal: New England Journal of Medicine (1967)

Type IV HyperlipoproteinemiaGeneral Definition. The Type IV lipoprotein pattern is the hallmark of endogenous hyperlipemia. It implies that glycerides synthesized in the body, usually in the liver, have been excreted into plasma at rates exceeding the capacity for removal. The appearance of a Type IV pattern often suggests that something has gone wrong with carbohydrate metabolism or caloric balance. There is evidence that it can sometimes mean inordinate emotional stress, excessive alcoholic intake or some other conflict between the patient and his environment. The development of this type of hyperlipoproteinemia is often conditioned by genotype.The Type IV . . .
The alcoholism of F. Scott Fitzgerald
Authors: D. W. Goodwin
Journal: JAMA (1970)

Alcoholism is unevenly distributed among, groups. More men than women are alcoholic, more Irishmen than Jews, more bartenders than bishops. The group, however, with possibly a higher rate of alcoholism than any other consists of famous American writers. Whether, as Hemingway said, most good writers are alcoholic is uncertain, but apparently a large number are. Of the seven Americans who were awarded the Nobel Prize for literature, four, according to their biographers, were alcoholics and a fifth drank heavily. If we compile a list of wellknown American writers of the past century, quite possibly one third to one half could be considered alcoholic. How to explain the high rate of alcoholism among authors? Is the association purely chance? Do writers drink because of the nature of their work or the life they lead? Do bad or obscure writers become alcoholic as often as famous writers? (Perhaps fame itself leads to
PRAGUE
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE PHYSICIAN AND PSYCHIC TREATMENT.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
NEUROSURGICAL TREATMENTS
Authors: A. D. Nanney, J. G. Adel, T. R. Smith, J. P. Chandler, K. T. Kimmell, K. Walter, B. E. Zacharia, C. Deibert, H. R. Malone, A. M. Sonabend, A. I. Neugut, B. Spencer, J. N. Bruce, Y. Wang, S. Li, Z. Zhang, X. Chen, G. You, P. Yang, W. Yan, Z. Bao, K. Yao, Y. Liu, L. Wang, T. Jiang, M. K. Farhoud, M. I. Ruge, A. A. Brandes, M. Ermani, A. Fioravanti, A. Andreoli, E. Pozzati, A. Bacci, S. Bartolini, R. Poggi, G. Crisi, E. Franceschi, P. F. Recinos, M. M. Grabowski, A. S. Nowacki, N. Thompson, M. A. Vogelbaum, P. Sun, D. Krueger, Z. Liu, M. Kohrman, A. B. Dagens, W. Rachinger, M. Kunz, S. Eigenbrod, J. Lutz, J.-C. Tonn, F.-W. Kreth, H. T. Duong, C. Chaloner, G. Bordo, A. Eisenberg, K. Rosenthal, M.-S. Sim, P. Boasberg, M. B. Faries, O. Hamid, D. F. Kelly, F.-W. Kreth, N. Thon, M. Simon, M. Westphal, G. Schackert, G. Nikkhah, B. Hentschel, T. Pietsch, G. Reifenberger, M. Weller, J.-C. Tonn, S. Ironside, J. Perry, M. Tsao, T. Mainprize, J. Keith, N. Laperrierre, L. Paszat, A. Sahgal, J. M. Hoover, M. Nwojo, R. Puffer, I. F. Parney, S. Tanaka, M. Nakada, Y. Hayashi, J.-i. Hamada, I. Y. Lee, T. Ekram, R. Jain, L. Scarpace, M. Omodon, J. Rock, M. Rosenblum, S. Kalkanis, N. M. Amankulor, J.-H. Kim, V. Tabar, K. K. Peck, A. I. Holodny, P. H. Gutin, C.-Y. Kim, Y.-H. Kim, T. Kim, I. K. Kim, J. W. Kim, Y. H. Kim, J. H. Han, C.-K. Park, D. G. Kim, H.-W. Jung, M. Nonaka, Y. Bamba, Y. Kanemura, S. Nakajima
Journal: Neuro-Oncology (2012)
A 61-year-old man with Parkinson's disease, 1 year later
Authors: W. E. Enker
Journal: JAMA (1997)

<h3>In Reply.</h3> —As the patient's primary physician, I agree with Dr Enker's important comments regarding the devastating effects Parkinson disease can have on patients and their families. Perhaps it would be most helpful to present some further information about the patient discussed in the Clinical Crossroads articles.<sup>1,2</sup>After he gave up his dental practice, faced with loss of esteem and with new financial burdens, Dr H became clinically depressed. He was treated with counseling and medication by a psychiatrist, in collaboration with his consulting neurologist and me. He received important social service support and had the good fortune to have a remarkably supportive and loving family. The therapy proved helpful and he gradually improved. This man of healing felt a need to continue on in his life as a healer and began volunteering in a local hospice. His participation in the Clinical Crossroads conference was a source of great pride to
Subgroup analysis by prior non-liposomal irinotecan therapy in NAPOLI-1: a phase 3 study of nal-IRI±5-fluorouracil/leucovorin in patients with metastatic pancreatic ductal adenocarcinoma previously treated with gemcitabine-based therapy
Authors: J.F. Blanc, R. Hubner, C-P Li, A. Wang-Gillam, G. Bodoky, A. Dean, Y-S Shan, G. Jameson, T. Macarulla Mercade, K-H Lee, D. Cunningham, C-F Chiu, G. Schwartsmann, F. Braiteh, D. von Hoff, L-T Chen, K. Mamlouk, F. de Jong, J. Siveke
Journal: Annals of Oncology (2017)
Preventi-Thought
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The tourniquet test in identifying diabetic retinopathy
Authors: A. A. Aaby
Journal: JAMA (1983)

<h3>In Reply.—</h3> My letter was a condensation of the article that, for lack of space, deleted most of the discussion and review of literature, including references cited by Drs Aaby and Zegarra. Obviously, the tourniquet test is not specific for diabetic microangiopathy, but the test result is infrequently abnormal in the nondiabetic population. Reported incidences are as follows: 6% of 268 medical students,<sup>1</sup>9% of 200 healthy adults,<sup>2</sup>and 8% of 50 nondiabetic patients in my study. Using the three-minute arm cuff occlusion as described in my letter, there was minimal discomfort or complaint by my patients. The test can be performed easily by the physician's assistant for a cost of about 50 cents for labor. The value of the tourniquet test to detect diabetic retinopathy is strongly supported by the study of Rodriguez and Root.<sup>3</sup>In 100 unselected diabetics, the test result was normal in 56
Adenosine does not mediate renal sodium retention and peripheral vasodilation elicited by partial portal vein ligation in rats
Authors: S Murakami
Journal: Hepatology (1996)

This study was conducted to assess the role of adenosine in the peripheral vasodilation and sodium retention that occurs after partial portal vein ligation (PVL) in the rat. The experiment was performed on day 1 after surgery when transient maximal sodium retention developed and day 7 when rats returned to sodium balance. Hemodynamic studies were conducted under anesthesia in portal hypertensive rats with sodium retention and in sham-operated controls. Measurements were obtained before and after administration of a nonselective A1 and A2 adenosine receptor antagonist 1,3-dipropyl-8-p-sulfophenylxanthine (DPSPX) (10 mg/kg intravenously followed by 150 μg/min). Under baseline conditions, portal hypertensive rats with sodium retention were hypotensive, with decreases in total peripheral resistance and filtration fraction on day 1 in comparison with the control group. Although hyperdynamic circulation was still maintained by day 7, there was a return to sodium balance. The adenosine receptor antagonist had a modest vasoconstrictor effect on systemic and renal vasculature in both groups, but less in portal hypertensive rats. However, no change in glomerular filtration rate was observed. DPSPX induced a natriuresis in control rats (from 0.40 ± 0.11 to 5.97 ± 0.61 mEq/min on day 1, from 0.48 ± 0.20 to 6.34 ± 0.45 mEq/min on day 7). This response was attenuated in portal hypertensive rats on day 1 (from 0.14 ± 0.04 to 1.67 ± 0.57 mEq/min), but not on day 7 (from 0.20 ± 0.06 to 5.11 ± 0.55 mEq/min). These results suggest that in portal hypertensive rats (1) adenosine is not responsible for vasodilation and sodium retention, (2) a sodium-retaining factor acting directly on the renal tubule is responsible for sodium retention.
BUCHAREST
Journal: JAMA (1924)

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MIDWIFERY AND GYNÆCOLOGY.
Journal: JAMA (1883)

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A Short Practice of Medicine.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Talwin 50 reformulated to avert 'T's and blues' abuse
Authors: C. Carlson
Journal: JAMA (1983)

In a move to reduce illegal use of the oral prescription analgesic Talwin 50, Winthrop Laboratories, a division of Sterling Drug Inc., has reformulated the drug so that if taken inappropriately, it will give abusers withdrawal-like symptoms rather than a "high." Talwin 50 (pentazocine hydrochloride), when crushed, dissolved together with the blue tablet tripelennamine (an antihistamine), and injected intravenously, provides a high similar to that of heroin (<i>JAMA</i>[MEDICAL NEWS] 1982;247:409). Several years ago, street people began to use the combination, called "T's and blues," as an alternative to costly heroin. The new formulation, which just went on the market, contains 50 mg of pentazocine and 0.5 mg of naloxone. Naloxone, a narcotic antagonist, is inactive when taken by mouth and does not affect the safety and efficacy of pentazocine when taken orally as intended, according to Sterling. However, if the new formulation—called Talwin Nx—is misused and taken intravenously, withdrawal