tbuckley/cabot-search huggingface dataset:
Noninvasive assessment of liver fibrosis: The need for better validation
Authors: Stella M. Martínez, Gonzalo Crespo, Miquel Navasa, Xavier Forns
Journal: Hepatology (2011)

We appreciate the letters of Tsochatzis et al. and Degos et al. regarding our recent review. We essentially agree with their comments but would like to stress a few points. It is obviously very relevant to maximize the diagnostic accuracy of any diagnostic test. In the case of noninvasive markers of liver fibrosis, the latter applies particularly to confirm or exclude the presence of cirrhosis, because there are important clinical implications derived from this finding (i.e., screening for hepatocellular carcinoma and gastroesophageal varices). We all would agree that in this setting most of the noninvasive methods widely used in clinical practice perform well. Regarding the identification of significant fibrosis, the diagnostic accuracy is certainly lower. However, their performance in the area of viral hepatitis C is probably acceptable. As an example in our own field, we are using the Model for End-Stage Liver Disease (MELD) score to predict the 3-month survival in patients awaiting liver transplantation (with the obvious consequences in a patient's life—or death) with diagnostic accuracies not far from those used to exclude significant fibrosis. The MELD score has been widely validated in different cohorts of patients with a prediction in 3-month survival ranging from 0.76-0.87.1, 2 Identifying or excluding significant fibrosis has limited practical implications in real life and, in the field of viral hepatitis, it may become less relevant once antiviral treatment efficacy increases. Regarding the comment by Tsochatzis et al. on the use of the collagen proportionate area as a histological standard (based on its quantitative nature) we believe this is a good approach.3 The prognostic value regarding patient outcome was excellent in their study, although the results need validation in other cohorts. Using such methodology, however, will not preclude one of the main problems of liver biopsy, which is sampling error. Finally, as we stressed in our review and as was noticed by Degos et al., using noninvasive methods to predict clinical outcomes is probably the most important goal. It is in this particular area where we need more and well-designed studies. Stella M. Martínez M.D.*, Gonzalo Crespo M.D.*, Miquel Navasa M.D., PH.D.*, Xavier Forns M.D., PH.D.*, * Liver Unit, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (Ciberehd), Barcelona, Spain.
My career as a radioisotope hunter
Authors: G. T. Seaborg
Journal: JAMA (1995)

My career as a radioisotope hunter began when I was working as a young scientist in the Radiation Laboratory at the University of California, Berkeley, during the trailblazing years in the late 1930s. I started this research in 1936 while a graduate student in the Department of Chemistry at Berkeley. The cyclotrons of Ernest O. Lawrence opened the doors to discovery, and as a chemist I was in the enviable position of being able to apply the powerful methods of my discipline to the identification of transmutation products. As a result of the broad interests of Ernest and his brother John, the scope of investigations in the Radiation Laboratory extended beyond basic research to include the practical interdisciplinary applications of these new tools of investigation. Special emphasis was placed on applications to medicine. Partly because of this and partly as a result of accidental good fortune, I became involved in
Apstatin, a new inhibitor of aminopeptidase P, reduces myocardial infarct size by a kinin-dependent pathway Sebastian Wolfrum, Andreas Dendorfer, Klaus Tempel, Gert Richardt. Medical Clinic II, University of L�beck, L�beck, Germany, Institute of exp. and clin. Pharmacology and Toxicology, University of L�beck, L�beck, Germany
Journal: Journal of the American College of Cardiology (2001)
A Manual of Otology.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Practical Local Anesthesia and Its Surgical Technic.
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ESPAC-4: A multicenter, international, open-label randomized controlled phase III trial of adjuvant combination chemotherapy of gemcitabine (GEM) and capecitabine (CAP) versus monotherapy gemcitabine in patients with resected pancreatic ductal adenocarcinoma.
Authors: John P. Neoptolemos, Dan Palmer, Paula Ghaneh, Juan W. Valle, David Cunningham, Jonathan Wadsley, Tim Meyer, Alan Anthoney, Bengt Glimelius, Stephen Falk, Ralf Segersvard, Jakob R. Izbicki, Gary William Middleton, Paul J. Ross, Harpreet Wasan, Alec Mcdonald, Tom David Lewis Crosby, Eftychia Eirini Psarelli, Pascal Hammel, Markus W. Buchler
Journal: Journal of Clinical Oncology (2016)

LBA4006 The full, final text of this abstract will be available at abstracts.asco.org at 2:00 PM (EDT) on Friday, June 3, 2016, and in the Annual Meeting Proceedings online supplement to the June 20, 2016, issue of the Journal of Clinical Oncology. Onsite at the Meeting, this abstract will be printed in the Monday edition of ASCO Daily News.
Dermatologic Therapy
Authors: John Godwin Downing
Journal: New England Journal of Medicine (1950)

Johnson et al.57 the discoverers of bacitracin, found it to be produced by gram-positive, sporulating organism of the Bacillus subtilis group. Meleney and Johnson58 report 88 per cent favorable response in the local treatment of 100 cases of surgical infection. In general, it may be stated that bacitracin is effective in vitro against gram-positive organisms both aerobic (streptococci, pneumococci, staphylococci, micrococci and corynbacteria) and anaerobic (clostridia, streptococci and micrococci), but ineffective against gram-negative organisms (bacilli of the coliform, proteus and pyocyaneus groups) with the exception of the gonococcus and the menin-gococcus, which are susceptible to its action. Fungi, such as . . .
Correction: Audit of a new appointment system in a hospital outpatient clinic
Journal: BMJ (1991)

h.>' * A study of admissions and discharges in psychiatry * Three studies for the genitourinary clinic, relating to genital warts, their treatment, and relation with cervical cancer in women, and a project determining incidence of chlamydia in cases of termination of pregnancy and the incidence of testing * Helping the haematology department to create a database of diagnoses in all outpatients and a study of the relation between anticoagulation and atrial fibrilla- tion * Analysis of records of all patients kept by the ortho- dontic department since 1984 according to waiting time, diagnosis, type and length of treatment, rate of non-attendance, and outcome * Analysis of the treatment and outcome of all major trauma patients over the past year * An audit of the activity in the observation ward * A study of the use of methotrexate treatment in patients with psoriasis and review of investigations in patients with leg ulcers * Standardisation of patient care in the coronary care unit by checking procedures relating to diagnosis for all patients in one month and repeating the process during the same month next year.Improvement of
The destruction of civilization in nuclear war
Authors: S. Jonas
Journal: JAMA (1984)

In discussions of the consequences of all-out nuclear war, most consideration is given to the death and physical destruction that would result from it. These are the most important consequences, of course, and from them alone, American society would be destroyed. However, in the back of the minds of those for whom nuclear war is thinkable seems to lurk the thought that recovery of the United States as a civilized nation is possible, if not immediately, then in 25 to 50 years. (And at least we would be rid of the Russians.) After all, they seem to reason, look what happened in Germany, Japan, and the Soviet Union after the mass destruction of their industrial bases in World War II. Allowing for radioactivity and all that, could not the same thing, albeit at a slower pace, happen again? For those who consider "protracted nuclear war" and who discuss the tactics
Therapeutic effect of a novel long-acting GLP-1/GIP/glucagon triple agonist (HM15211) in animal models of NASH and fibrosis
Authors: Jung Kuk Kim, Jong Suk Lee, Hyo Sang Jo, Hyunjoo Kwon, Eun Jin Park, Dae Jin Kim, Sang Hyun Lee, Young Hoon Kim, In Young Choi
Journal: Journal of Hepatology (2020)
Chromosome Mosaicism Is Difficult to Diagnose
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
High Frequency Currents: Their Production, Physical Properties, Physiologic Effects and Therapeutical Uses.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Innovative ways to fight cancer dominate 1989 AMA Houston science news conference
Journal: JAMA (1989)

ALTHOUGH acquired immunodeficiency syndrome (AIDS), cholesterol, and drug abuse have grabbed recent science news headlines, cancer quietly persists as the number two killer in the United States. This might explain the air of exigency surrounding presentations by cancer experts at the American Medical Association's (AMA) Eighth Annual Science Reporters Conference. The 3-day conference was appropriately located in Houston, Tex, where part of the continuing war against cancer is being waged with extensive research and therapeutic efforts. A number of conference presentations dealt with novel approaches to cancer prevention and treatment, ranging from genetic therapy for cancer, targeting of anticancer drugs, the relationship between nutrition and cancer, to cancer vaccines. <h3>Cancer Vaccines</h3> David Hohn, MD, associate professor of surgery at the M. D. Anderson Cancer Center, University of Texas, Houston, compares the concept of immunizing individuals against cancer with strategies for the prevention of polio or measles. A vaccine against malignant
Abstract P112: Precordial Thump Ineffective in Terminating Ventricular Fibrillation but May Have a Role in Asystole
Authors: Christopher Madias, Barry J Maron, Alawi A Alsheikh-Ali, Barbara Murphy, Lara Egerhei, N. A. Mark Estes, Mark S Link
Journal: Circulation (2008)

BACKGROUND. The efficacy of the chest thump in cardiac arrest is controversial. In an animal model of cardiac arrest we assess the efficacy of precordial thump in ventricular fibrillation (VF) and asystole. METHODS. Under general anesthesia, 10 swine were induced to VF using a RV pacing lead and an AC fibrillator. In random order, animals received chest thumps with a 30 or 40 mph lacrosse ball or a chest thump with a fist. If VF continued after 3 thumps, animals were externally defibrillated. All animals underwent 6 VF inductions and received a total of 18 chest thumps; 2 sets of 3 thumps each with a fist, 30 mph, and 40 mph lacrosse balls. If asystole followed defibrillation, chest thumps with a fist were given to induce premature ventricular contractions (PVCs) until resumption of sinus rhythm. LV pressures of all thumps were recorded. RESULTS. None of the 180 chest thumps terminated VF. The LV pressure generated by thumps during VF was 263 ± 52 mmHg for manual thumps, 392 ± 179 mmHg for 30 mph thumps, and 616 ± 182 mmHg for 40 mph thumps (p&lt;0.001). All VF episodes were terminated by a 200J shock. Defibrillation was followed by asystole after 46/60 (77%) of VF inductions. During asystole, 1533/1856 (83%) chest thumps induced PVCs. LV pressure was higher for thumps that induced PVCs than those that did not (113 ± 27 vs 75 ± 23 mmHg, p&lt;0.001). For each 10 mmHg rise in LV pressure, the OR of inducing a PVC was 1.9 (95% CI 1.8 –2.1; Figure ). CONCLUSIONS. Despite achieving high LV pressures, precordial thumps were not effective in terminating VF, but did produce PVCs in asystole. Based on this data, a precordial thump cannot be recommended for VF, but its use in asystole should be further explored.
A MEDICAL CONGRESS SHIPBOARD.
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Esophagus
Authors: Alan T. Marty
Journal: JAMA (1974)

This succinct text updates knowledge of esophageal disease in the best possible way: by drawing from extensive, original Mayo Clinic data and selectively interweaving current and classical references. The contents range from esophagomotor disturbances, reflux and chemical injuries, webs, varices, endoscopic techniques, congenital disorders, and tumors to esophagogenic pulmonary complications. Historical, anatomical, physiological, medical, and surgical aspects are all well covered. The authors' editorial skill prevents multiauthor redundancy, while their wide experience permits textual insertion of many pearls. For example, in the removal of pedunculated, intraluminal esophageal tumors, a surgical approach through the side opposite the pedicle is recommended to permit more accurate exposure and excision of the pedicle base. For the emergency treatment of a "café coronary" (meat obstructing at the level of the cricopharyngeus), use of a curved hemostat or fork is suggested to hook out the meat via the side of the mouth. The priority controversy over
THE EQUIVALENT OF ORDINARY EXERTION
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Surgeons Prepare to Implant Mechanical Heart in Humans
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Une nouvelle syphilis nerveuse: Ses formes cliniquement inapparentes
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal