tbuckley/cabot-search huggingface dataset:
Living With AIDS
Authors: Monnie Callan
Journal: JAMA (1991)

The worldwide pandemic of the acquired immunodeficiency syndrome (AIDS), which was first manifest a scant 10 to 12 years ago, has assumed a kaleidoscope of identities. In one short decade, the name of the disease progressed from gay-related immune disease (GRID), to HTLV-III (human T-cell lymphotropic virus type III) infection, to HIV (human immunodeficiency virus) infection, and its stages of development added yet further acronyms: ARC (AIDS-related complex) and AIDS itself. Some of these terms, though obsolete, have become enshrined in the language of bureaucracy, which defines eligibility for social services and entitlement. The terminology of the AIDS social movement in the United States has also evolved. Social activists have rejected the pity and dependency that they believe are embodied in such terms as "AIDS victims" or even "AIDS patients." They prefer terms of empowerment and the neutral "people with AIDS" (PWAs). They eschew "innocent victims," often employed when describing
PDTM-38. PEDIATRIC MENINGIOMAS ARE CHARACTERIZED BY DISTINCT METHYLATION PROFILES DIFFERENT FROM ADULT MENINGIOMAS
Authors: Christian Mawrin, Elmar Kirches, Felix Sahm, Christina Bluecher, Svenja Boekhoff, Ulrich Schüller, Jens Schittenhelm, Matija Snuderl, Matthias Karajannis, Arie Perry, Thorsten Pietsch, Hermann Mueller, David Capper, Katja Beck, Matthias Schlesner, Siegfried Kropf, Priscilla Brastianos, Andrey Korshunov, Stefan Pfister
Journal: Neuro-Oncology (2018)

In contrast to adulthood, meningiomas are rare among children and adolescents. However, the molecular relations between both groups have not been elucidated in detail. We have analyzed 41 tumor samples from 37 pediatric meningioma patients (female: 17, male: 20; age range: 1–21 years). Atypical meningioma WHO grade II was the most frequent histological subtype (N=14, 38%). Most tumors were located at the convexity (N=18) or the skull base (N=15). Lack of SMO, AKT, KLF4/TRAF7 mutation in Sanger sequencing (n=22) prompted whole genome sequencing of a subset (n=7). All cases exhibited bi-allelic mutation of NF2 (combined large deletion and germline (5/7) or somatic (2/7) base exchanges/frameshifts). Subsequently, representative samples of all 37 patients were subjected to 450K DNA methylation profiling and remaining DNA to sequencing of a brain tumor specific gene panel. Loss of chromosome 22 was frequently detected (N=28, 76%), followed by loss of chromosome 1 (N=12, 32%) and chromosome 18 (N=7, 19%). Moreover, a separation into three groups was evident: One group covering all clear-cell meningiomas with enrichment for SMARCE1 mutations, a second group dominated by atypical meningiomas, and a third group covering benign WHO grade I meningiomas, as well as rare subtypes such as rhabdoid meningiomas. Compared to adult tumors, the majority of pediatric meningiomas clustered in a separate group both by unsupervised hierarchical and clustering and t-stochastic nearest neighbor embedding. Analysis of four tumor recurrences did not reveal changes compared to the primary tumor. These data suggest that pediatric meningiomas are fundamentally different from adult counterparts.
Edge-to-Edge Mitral Repair
Authors: Sten Lyager Nielsen, Tomasz A. Timek, David T. Lai, George T. Daughters, David Liang, J. Michael Hasenkam, Neil B. Ingels, D. Craig Miller
Journal: Circulation (2001)

Background Edge-to-edge approximation of the mitral valve leaflets (Alfieri procedure) is a novel surgical treatment for patients with ischemic mitral regurgitation (IMR). Long-term durability may be limited if abnormal mitral leaflet stresses result from this procedure. The aim of the current study was to measure Alfieri stitch tension (F A ) and to explore its geometric determinants in an ovine model of acute IMR as a reflection of the mitral leaflet stresses imposed by the procedure. Methods and Results Eight sheep were studied immediately after surgical placement of (1) a force transducer interposed between sutures approximating the central leaflet edges and (2) radiopaque markers around the mitral annulus and leaflet edges. Computer-aided analysis of videofluorograms was used to obtained 3D marker coordinates. Simultaneous measurements of F A , septal-lateral annular dimension (L S-L ), leaflet edge separation (L SEP ), anterior (L AL ) and posterior (L PL ) leaflet length, and hemodynamic variables were obtained at baseline (CTL) and during acute IMR (circumflex artery occlusion). F A was significantly elevated throughout the cardiac cycle during IMR compared with CTL, with maximum F A in diastole (0.26±0.05 versus 0.46±0.08 N, CTL versus IMR; P &lt;0.05). Multivariable analysis revealed L S-L as the single independent predictor of maximum F A ( P &lt;0.001). Positive linear correlations were shown between values of F A and L AL and L PL (dependent variables). Conclusions These experimental data demonstrate higher F A during IMR and cyclic changes in F A closely paralleling changes in L S-L , eg, being greatest in diastole when the annulus is largest. Increased F A during IMR is probably indicative of successful therapeutic intent, but higher diastolic leaflet stresses resulting from persistent or progressive mitral annular dilatation may adversely affect repair durability. This indirectly implies that concomitant mitral ring annuloplasty should be added to the Alfieri repair.
Ostomies
Authors: J. K. Stucke
Journal: CA A Cancer Journal for Clinicians (1986)

ing the past five years there is a trend of better results.Our five-year survival rate is90.4percent.The surgical results for those with Dukes' A are not better, but are not significantly different.Our patients, however, do not require a colostomy, there is no hospitalization, and there is no loss of sexual function.
The addition of imatinib mesylate to estramustine/docetaxel (E/D) for the treatment of hormone refractory prostate cancer (HRPC) patients: Results of a phase I trial
Authors: M. Randall, B. Rini, C. Ryan, J. Rosenberg, J. Garcia, G. Bubley, E. J. Small
Journal: Journal of Clinical Oncology (2004)

4617
THE LOCAL ACTION OF THE X RAYS.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ESGE Newsletter
Journal: Endoscopy (2009)

ESGE, ESGENA and the Romanian Society of Gastrointestinal Endoscopy (SRED) joined forces to organize the ESGE Live Endoscopy Workshop in Cluj-Napoca, Romania, October 15 – 16, 2009 with Cristian Gheorghe acting as ESGE Co-Director, Oliviu Pascu as Director and Sylvia Lahey as ESGENA Co-Director.
RECURRENT UPPER GASTROINTESTINAL ULCER BLEEDING TREATED BY COILS EMBOLIZATION GUIDED BY ENDOSCOPIC ULTRASONOGRAPHY (EUS)
Authors: L Medina-Prado, S Baile-Maxía, M Bozhychko, C Mangas-Sanjuán, JM Sempere, B Martínez, L Compañy, F Ruiz, JA Casellas, JR Aparicio
Journal: Endoscopy (2020)

We report two clinical cases of EUS-guided coils embolization in upper gastrointestinal bleeding due to peptic ulcer.
WAR GASES AND TUBERCULOSIS
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Epigenetic Effects of Liver Tumor Promoters and Implications for Health Effects
Authors: Gary M. Williams
Journal: Environmental Health Perspectives (1983)

During chemical carcinogenesis in the liver, a population of abnormal cells in lesions referred to as altered foci precedes the appearance of neoplasms.Most altered foci do not develop further, but a small fraction progress to formation of neoplasms.Liver tumor promoters increase the fraction that progress.The mechanisms for this action of promoters may involve an effect on the cell membrane.Cells in vivo and in vitro exchange molecules through specialized membrane organelles known as gap junc- tions.Intercellular transfer of growth and/or differentiation regulating factors could be involved in suppressing the growth of initiated cells in the altered foci.Several liver tumor promoters have been found to inhibit intercellular communication in an in vitro liver culture system.This effect on the cell membrane could, thus, be the basis for the release of cells in foci for further growth into neoplasms.Such an epigenetic action would account for the requirement for high doses and pro- longed exposure for certain liver tumor promoters.In addition, it implies a distinct type of health risk analysis for chemicals of this type.Several chemicals, particularly halogenated hydrocarbons, produce primarily or exclusively an increase in liver tumors in rodent strains that are characterized by a substantial background inci- dence of such tumors.These chemicals have not been demonstrated to have the DNA damaging ca- pability of genotoxic carcinogens and several enhance the hepatocarcinogenicity of previously administered liver carcinogens.Moreover, they exert an inhibition of intercellular communication.Thus, carcinogens of this type may be epigenetic carcinogens functioning as liver tumor promoters.Accordingly, the health risk analysis for these chemicals is different from that for genotoxic carcin- ogens.
Cardiology 1981
Authors: Irwin R. Callen
Journal: JAMA (1981)

<i>Cardiology 1981</i>is the kind of book I like to read. It comprises a review of the cardiology literature of the 1980 calendar year with summaries of 452 articles published in a variety of English-language medical journals. It is profusely illustrated, and its size makes it easy to carry. There are ten chapters, each of which covers a disease entity. Chapter 1, on the general aspects of coronary heart disease, occupies one fourth of the book. Chapter 2, on acute myocardial infarction, takes up 40 pages, and is a further indication of the importance of atherosclerosis in the cardiology literature and practice of medicine. Other chapters cover cardiac arrest and arrhythmias, systemic hypertension, valvular heart disease, myocardial heart disease, congenital heart disease, drugs for congestive heart failure and echocardiography. The last chapter reviews several related topics, including pericardial and pulmonary heart disease, intra-aortic balloon counterpulsation, and other miscellaneous subjects. For
Digoxin therapy during T-tube biliary drainage in man
Authors: S. G. Carruthers
Journal: JAMA (1978)

BILIARY excretion and enterohepatic recirculation of digitoxin has been demonstrated in man.<sup>1</sup>Recently it has been recognized that digoxin may also undergo biliary elimination and enterohepatic recycling.<sup>2,3</sup>We report the consequence of biliary excretion of digoxin in a patient subjected to bile drainage after cholecystectomy. <h3>Report of a Case</h3> An 82-year-old man weighing 59 kg was taking digoxin, 0.125 mg/day; 1-thyroxine, 0.2 mg/day; and furosemide, 40 mg/day. He was jaundiced and dyspneic. Moist rales at both lung bases and gallop rhythm were present. The right upper quadrant was tender to deep palpation. Sonography demonstrated a distended gallbladder with numerous small calculi. Blood cell counts showed leukocytosis with an increased number of polymorphonuclear leukocytes. There was a threefold elevation of the normal serum bilirubin and alkaline phosphatase levels; BUN levels ranged from 29 to 48 mg/dl, and serum creatinine levels ranged from 1.3 to 2.0 mg/dl. Creatinine clearance calculated
La coloscopie en France en 2004: résultat d'une enquête prospective nationale de la Société Française d'Endoscopie Digestive
Authors: JM Canard, JP Arpurt, C Boustière, J Boyer, J Cassigneul, PA Dalbies, J Escourrou, G Gay, R Laugier, JC Letard, B Napoléon, L Palazzo, T Ponchon, B Richard-Molard, D Sautereau, G Tucat, B Vedrenne
Journal: Endoscopy (2006)

Le but de ce travail a été de décrire et quantifier prospectivement l'ensemble des coloscopies réalisées en France et son évolution depuis 1998.
Human Papillomavirus and Papanicolau Tests to Screen for Cervical Cancer
Journal: New England Journal of Medicine (2008)

A nyone who has had even one poor night of sleep will immediately recognize the substantial impact of sleep disturbance on quality of life.Sleep and Quality of Life in Clinical Medicine explores this problem under a magnifying glass.The first few chapters of the book provide an overview of the relationship between sleep and quality of life.The chapters that follow are loosely organized by type of condition: sleep, neurologic, psychiatric, substance abuse-related, cardiovascular, digestive, respiratory, endocrine, oncologic, and infectious.Most chapters share a specified format, beginning with a summary and lists of keywords and learning objectives and closing with conclusions and a review of problems that need to be addressed in future research.This format provides a consistency that enhances the usefulness of the book.There is also consistency of content.Too often in books like this one, some chapters cover a few major topics comprehensively whereas others have only sparse material on a wide range of topics.In this book the authors and editors have achieved relative consistency of content.Who will find this book useful?The primary readership should be sleep clinicians, researchers, and medical and postdoctoral students.The book's strengths include an easily readable style, with little medical jargon, and it is comprehensive yet concise.The first five chapters are among the best written, setting the stage for later chapters by defining quality of life in health, describing assessment and measurement tools, and summarizing categories of sleep disorders.Other notable chapters deal with quality of life in sleep apnea, multiple sclerosis, eating disorders, and cancer.Another major strength of the book, however, is also a weakness -although the book fully explores the relationship between sleep and quality of life, this specialized area of study is still in its infancy.Consequently, the data on quality of life are sparse for some of the sleep disorders and medical conditions described.Nevertheless, one would be hard pressed to identify a topic concerning sleep and quality of life that is not covered.
Commentaire de travail de D. von Renteln et al., pp. 173
Journal: Endoscopy (2008)

See also: Endoscopic full-thickness plication (Plicator) with two serially placed implants improves esophagitis and reduces PPI use and esophageal acid exposureEndoscopy 2008; 40(03): 173-178DOI: 10.1055/s-2007-995515
VIENNA
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
DISCUSSION ON PAPER OF DR. J. M. ANDERS OF PHILADELPHIA, "MYXEDEMA WITH REPORT OF TWO CASES."
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reply
Authors: A. Prendiville, M. Silverman
Journal: Thorax (1987)

Paradoxical response to nebulised salbutamol in wheezy in- fants SIR, We were interested in the paper by Dr Anne Pren- diville and others (January 1987;42:86-91) showing a significant decline in maximum flow at functional residual capacity (VmaxFRC') in wheezy infants after nebulised sal-
Quarterly AIDS Map
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Octreotide blunts postprandial splanchnic hyperemia in cirrhotic patients: A double-blind randomized echo-doppler study*1
Authors: P BUONAMICO
Journal: Hepatology (1995)

The effect of octreotide, a long-acting synthetic analog of somatostatin, on fasting and postprandial splanchnic hemodynamics was investigated in cirrhotic patients. Splanchnic hemodynamics were assessed using an echo-Doppler duplex system in a prospective, double-blind, placebo-controlled, crossover study performed on 2 separate days, 1 week apart, in 30 cirrhotic patients. Measurements of portal vein (PV) cross-sectional area (PVA) and mean velocity (PV-V), and of superior mesenteric artery (SMA) mean velocity (SMA-V) and pulsatility index (SMA-PI) (an index of vascular resistance) were performed at baseline, 30 minutes after octreotide (200 μg subcutaneously) or placebo administration, and 30 and 60 minutes after the ingestion of a liquid meal. In the fasted state, octreotide induced a significant decrease in PV-V (−7%) and in SMA-V (−10%) and an increase in PI (+16%). On the day of placebo administration, meal ingestion induced a significant increase in PV-V (+21%) and in SMA-V (+43%) and a decrease in PI (−21%). In contrast, meal ingestion on octreotide day induced significantly smaller increases in PV-V (+10%) and in SMAV (+18%) and a significantly smaller decrease in PI (−10%). Octreotide, although producing a mild reduction in PV-V and SMA-V in the fasted state, markedly blunts postprandial splanchnic hyperemia in cirrhotic patients.
Ventriculographic-echocardiographic correlation in patients with asynergy
Authors: C. A. Morrison
Journal: JAMA (1978)

The ability of echocardiography to detect segmental ventricular asynergy was evaluated in 41 patients before cardiac catheterization. Of 24 normal posterior wall segments by echocardiography, 23 were also normal by ventriculography, while one was hypokinetic. Of 17 asynergic posterior wall segments by echocardiography, 15 were asynergic and two were normal by ventriculography. Posterior wall excursion for the normal group was 1.30± 0.18 cm (SD), while those demonstrating hypokinesis on ventriculography showed an excursion of 1.05±0.19 cm (<i>P</i>&lt;.005), and akinetic segments showed an excursion of 0.97±0.13 cm (<i>P</i>&lt;.005). In 15 patients, septal motion as determined by echocardiography was compared with the left anterior oblique ventriculogram. Of nine normal septal motions by echocardiography, seven were also normal by left anterior oblique ventriculography (septal excursion, 0.84±0.25 cm). Of six patients with decreased echocardiographic septal motion, four were normal and two were abnormal by ventriculography. Although normal echocardiographic septal motion correlated well with ventriculography, decreased septal excursion by echocardiography did not. (<i>JAMA</i>239:1855-1859, 1978)