tbuckley/cabot-search huggingface dataset:
Next influenza vaccine set
Authors: C. Marwick
Journal: JAMA (1988)

AS THE CURRENT influenza season winds down (see accompanying article), infectious disease experts are preparing for future outbreaks. For example, two new isolates will be in the vaccine prepared in this country for the late 1988 and early 1989 influenza season. The Centers for Disease Control, Atlanta, says the decision has been made to include A/Sichuan/2/87 for the H3N2—that is, the antigenic hemagglutinin and neuraminidase glycoproteins of the viral coat—component and a Victoria-like isolate for the B component (<i>JAMA</i>1988;259:977). The H1N1 component will remain the Taiwan isolate that is in the current vaccine (<i>JAMA</i>1988;259:1131). The isolates have been prepared for the large-scale vaccine effort that must be undertaken between now and the next influenza season, and the strains sent to the manufacturers. This involves making mutant strains of the virus that have growth potential, yet possess antigenicity. At the same time, the United Nations' World Health Organization (WHO)
Amebiasis of clitoris mimicking carcinoma
Authors: B. Majmudar
Journal: JAMA (1976)

AMEBIC infection of the genital tract is rare, even in countries where intestinal amebiasis is endemic. To our knowledge, 75 cases of amebiasis of the female genital tract have been reported in the English literature,<sup>1-10</sup>only six of them being from the United States.<sup>1-3</sup>The last reported case of genital amebiasis from this country was in 1954.<sup>3</sup>Furthermore, although cervical, vaginal, and vulvar amebiasis has been reported, a case of exclusive clitoral involvement has not been previously cited. <h3>Report of a Case</h3> A 48-year-old woman came to the out-patient clinic of the Grady Memorial Hospital with a nine-month history of a painful and pruritic vulvar lesion. Her physician had treated her with nystatin suppositories, but she failed to improve. She denied any gastrointestinal, genitourinary, and systemic symptoms, except for a burning micturition. <h3>Clinical Findings.—</h3> In the clitoral region, there was a well-circumscribed, greyish-white, slightly elevated, fungating lesion
Ambulatory management of thromboembolic disease during pregnancy with continuous infusion of heparin
Authors: M. C. Brabeck
Journal: JAMA (1987)

THROMBOEMBOLIC events related to pregnancy are not uncommon. Retrospective studies have shown an incidence as high as one in 70 pregnancies when thrombophlebitis of either the superficial or deep venous systems occurring in the antepartum or postpartum period is considered.<sup>1</sup>The following report describes continuous intravenous (IV) infusion of heparin sodium in the ambulatory setting, an uncommon approach to treating these patients. <h3>Report of a Case</h3> A 32-year-old woman with a history of a documented pulmonary embolus while receiving oral contraceptives and a previously uneventful pregnancy was admitted to the hospital in the eighth week of gestation, with pain and swelling of the right lower extremity. Plethysmographic and Doppler study results suggested acute obstruction in the right popliteal system and further diagnostic studies were not pursued. A bolus of 5000 units of heparin sodium was given, followed by a continuous infusion of approximately 1000 U/h for eight days. There
Application of Serial Angiography to Diagnosis of the Smallest Cerebral Angiomatous Malformations
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Regulation of the germinal center gene program by interferon (IFN) regulatory factor 8/IFN consensus sequence-binding protein
Authors: Chang Hoon Lee, Mark Melchers, Hongsheng Wang, Ted A. Torrey, Rebecca Slota, Chen-Feng Qi, Ji Young Kim, Patricia Lugar, Hee Jeong Kong, Lila Farrington, Boris van der Zouwen, Jeff X. Zhou, Vassilios Lougaris, Peter E. Lipsky, Amrie C. Grammer, Herbert C. Morse
Journal: The Journal of Experimental Medicine (2008)
Council on Medical Education and Hospitals
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Satellite Broadcast on Managing Occupational Exposures to HIV
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SHIP SURGEONS
Authors: H. J. Philpot
Journal: BMJ (1910)

with suffering humanity.There exists already a great deal too much preventable human misery, and it is intolerable that increase of this should be possible to 8o enormous an extent through lack of the simple laws neeaed to put a stop to the practices of the most cynical and cruel section of the great army of criminals of every class now parasitic upon society.-Iam, etc., Redhill, Nov. 26th.HENRY SEWILL. SIR,-Dr
IB. Medical Schools in Canada
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Future Directions in the Use of DNA Adducts As Internal Dosimeters for Monitoring Human Exposure to Environmental Mutagens and Carcinogens
Authors: Curtis C. Harris
Journal: Environmental Health Perspectives (1985)

Scientific opportunities generally arise when two or more research areas converge and/or advances in methodology occur. This occurred at the turn of the 19th century in the field of infectious bacterial and fungal diseases. As we draw near to the 21st century, research in the laboratory is providing us with both critical information on mechanisms of carcinogenesis and new technological advancements, including those in immunology, biochemistry, and molecular biology. Investigations in the field of epidemiology have clearly demonstrated the importance of environmental exposure to carcinogens and have identified populations at high cancer risk. It is now practical to integrate laboratory determinations into classic epidemiological approaches. Several markers, e.g., carcinogen-DNA adducts, related to tumor initiation and perhaps to tumor conversion, are currently being evaluated. We also need to develop indicators of tumor promotion and progression. The potential of biochemical and molecular epidemiology to predict cancer risk in an individual prior to the onset of clinically evident cancer provides an exciting new opportunity in cancer research and prevention.
Food for thought: endocannabinoid modulation of lipogenesis
Authors: A. H. Lichtman
Journal: Journal of Clinical Investigation (2005)

An emerging body of evidence implicates peripheral and central endocannabinoid pathways in the regulation of feeding behavior and body weight. A report in this issue of the JCI demonstrates the presence of a common endocannabinoid-regulated molecular pathway for peripheral lipogenic and central appetitive regulation. This pathway involves the activation of the transcription factor SREBP-1c and its associated enzymes, acetyl-CoA carboxylase-1 and fatty acid synthase, in the liver and hypothalamus. Activation of cannabinoid receptor 1 (CB1) in liver plays a key role in increased serum lipid production, fatty liver, and possibly diet-induced obesity. Conversely, stimulation of these receptors in the hypothalamus may lead to an increase in food consumption. Thus, targeting both of these pathways with CB1 antagonists could promote sustained weight loss and favorable serum lipid profiles in obese patients.
Hydrocephalus
Authors: Donald D. Matson
Journal: New England Journal of Medicine (1964)

THE common denominator in all varieties of hydrocephalus is dilatation of all or part of the cerebrospinal-fluid-containing spaces because the pressure of the fluid within them is or has been excessive. The clinical picture that results from hydrocephalus itself, therefore, is that of increased intracranial pressure; in infancy, before the cranial sutures have united, this picture includes, or may be solely manifested by, enlargement of the head.As of 1964, the treatment of hydrocephalus is surgical, since no medical or radiologic therapy is known to be of any significant benefit, except to the extent that an obstructive neoplasm may be . . .
The sunny side of aging
Authors: J. F. Fries
Journal: JAMA (1990)

When confronting the health and medical care costs of the aging of America, there are optimists and there are pessimists. In a most curious way the "optimists" have become those who believe that life is limited and that the average life expectancy of seniors is unlikely to grow rapidly in the future. "Pessimists" are those who believe that life expectancy increases will continue, and perhaps will even increase in the future. In a thoughtful article in this issue of<i>JAMA</i>, Schneider and Guralnik<sup>1</sup>beat the pessimistic drum loudly and clearly. Medicare costs may rise sixfold by the year 2040 in constant 1987 dollars. Dementia might ultimately afflict 28% or more of the senior population. We might expect 800 000 hip fractures annually by the year 2040. Research funding for the conditions that will pose the largest health care problems in the next century, including osteoarthritis, osteoporosis, and Alzheimer's disease,
A first-in-class, first-in-human phase I trial of KPT-330 (selinexor), a selective inhibitor of nuclear export (SINE) in patients (pts) with advanced solid tumors.
Authors: Morten Mau-Soerensen, Albiruni R. A. Razak, Anthony Frank Shields, Nashat Y. Gabrail, John F. Gerecitano, Sharon Shacham, Ulrik Niels Lassen, Tami Rashal, Jennifer Cooksey, Yosef Landesman, Gregory Pond, Amit M. Oza, Michael Kauffman, Lillian L. Siu, Philippe L. Bedard, Hemchandra Mahaseth, Mansoor Raza Mirza, Amit Mahipal
Journal: Journal of Clinical Oncology (2014)

2537 Background: KPT-330 is an inhibitor of Exportin 1 (XPO1) that forces the nuclear retention and activation of over 10 Tumor Suppressor Proteins (TSPs) resulting in tumor cell death in preclinical models. Methods: KPT-330 was administered orally for 8-10 doses in a 28-day cycles. Cycle 1 was the DLT period. Pharmacokinetic (PK) analyses were performed. XPO1 mRNA, a pharmacodynamic (PDn) marker of XP01 inhibition, was assessed in blood. Tumor biopsies were performed. Response was evaluated every 2 cycles (RECIST 1.1). All pts had to have documented progressive disease on study entry. Results: 103 pts (59/44 M/F; median age 61 yrs; median treatment regimens: 3; ECOG PS 0/1: 24/79) received KPT-330 across 12 dose levels (3 to 65 mg/m2) in dose escalation and expansion cohorts. 2 DLTs (fatigue, dehydration) at 40mg/m2 on the 10-doses/cycle regimen; 1 DLT (nausea) at 35mg/m2 on the 8-doses/cycle (twice weekly, BIW) regimen were noted. Dosing at 65mg/m2 BIW is ongoing (MTD not reached). Grade 3/4 non-DLT, drug related, adverse events (AEs) in cycle 1 in >2 pts: hyponatremia (9%), fatigue (6%), thrombocytopenia (5%), vomiting (4%), anemia (3%), nausea (3%). The most common grade 1/2 AEs in cycle 1: nausea (63%), fatigue (52%), anorexia (42%) and vomiting (37%). The PK and PDn showed dose-dependent increases in Cmax / AUC0-inf and XPO1 mRNA increases. Tumor biopsies showed nuclear localization of TSPs (p53, FOXO3A, IkB) and apoptosis induction. Of 87 response evaluable pts, 3 partial responses were observed in colorectal cancer (KRAS mutant), melanoma (BRAFwt) and ovarian adenocarcinoma (OvCa) pts. Stable disease (SD) was noted in 39 pts, with 12 pts for ≥6 months. Five of 5 evaluable pts with hormone and chemotherapy refractory prostate cancer (HRPC) achieved SD; all pts still on study 70-240+ days. Nine of 13 evaluable pts with squamous head and neck cancer (HNCa) achieved SD with 7 on study 75-290+ days. Conclusions: Oral KPT-330 has a manageable toxicity profile and prolonged dosing is feasible. Preliminary signals of durable antitumor activity were observed. The recommended dose for phase 2 is ≥50mg/m2 BIW. Phase 2 studies in HNCa, OvCa, and HRPC are planned. Clinical trial information: NCT01607905.
The Prevalence and Correlates of Adult ADHD in the United States: Results From the National Comorbidity Survey Replication
Authors: Ronald C. Kessler, Lenard Adler, Russell Barkley, Joseph Biederman, C. Keith Conners, Olga Demler, Stephen V. Faraone, Laurence L. Greenhill, Mary J. Howes, Kristina Secnik, Thomas Spencer, T. Bedirhan Ustun, Ellen E. Walters, Alan M. Zaslavsky
Journal: American Journal of Psychiatry (2006)

Objective: Despite growing interest in adult attention deficit hyperactivity disorder (ADHD), little is known about its prevalence or correlates. Method: A screen for adult ADHD was included in a probability subsample (N=3,199) of 18–44-year-old respondents in the National Comorbidity Survey Replication, a nationally representative household survey that used a lay-administered diagnostic interview to assess a wide range of DSM-IV disorders. Blinded clinical follow-up interviews of adult ADHD were carried out with 154 respondents, oversampling those with positive screen results. Multiple imputation was used to estimate prevalence and correlates of clinician-assessed adult ADHD. Results: The estimated prevalence of current adult ADHD was 4.4%. Significant correlates included being male, previously married, unemployed, and non-Hispanic white. Adult ADHD was highly comorbid with many other DSM-IV disorders assessed in the survey and was associated with substantial role impairment. The majority of cases were untreated, although many individuals had obtained treatment for other comorbid mental and substance-related disorders. Conclusions: Efforts are needed to increase the detection and treatment of adult ADHD. Research is needed to determine whether effective treatment would reduce the onset, persistence, and severity of disorders that co-occur with adult ADHD.
Neprilysin-neuropeptide Y axis as a target for treatment of liver fibrosis and portal hypertension
Authors: Cristina Ortiz, Sabine Klein, Winfried Reul, Fernando Magdaleno, Stefanie Gröschl, Peter Dietrich, Robert Schierwagen, Frank Uschner, Olaf Tyc, Stefan Zeuzem, Christoph Welsch, Marko Poglitsch, Claus Hellerbrand, Mercedes Alfonso-Prieto, Thomas Walther, Jonel Trebicka
Journal: Journal of Hepatology (2020)
Nutritional Status of Children Participating in the Special Supplemental Nutrition Program for Women, Infants, and Children—United States, 1988-1991
Journal: JAMA (1996)

Recent increases in the prevalence of overweight among school-aged children (1) and adults (2) in the United States have prompted concern about an increase in overweight among preschool-aged children and a possible association with the foods provided by the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC). To assess and compare weight status and nutrient intake among WIC participants and other low-income children, CDC analyzed data from phase 1 of the Third National Health and Nutrition Examination Survey (NHANES III), 1988-1991. This report summarizes the results of this analysis, which indicate that foods provided by WIC are not associated with increased overweight among preschool-aged children.
Chemonucleolysis
Authors: Peter H. Wright
Journal: JAMA (1990)

<h3>To the Editor.—</h3> The Diagnostic and Therapeutic Technology Assessment (DATTA) article on chemonucleolysis<sup>1</sup>contains significant omissions and inaccuracies. For example, anaphylaxis is an important adverse effect of chemonucleolysis but its incidence is exaggerated. Postmarketing surveillance carried out by the manufacturers between 1982 and 1988 shows an overall incidence of 0.46%, but during 1987 and 1988 it was only 0.18%. A recent panEuropean survey of chemonucleolysis has suggested a similar rate of anaphylaxis at 0.2%.<sup>2</sup>Also, while postmarketing surveillance suggests that anaphylaxis occurs more frequently in females (0.68%) than in males (0.18%), this difference is not as great as that (6- to 10-fold) suggested in the article. It is stated in the DATTA article that the dose of chymopapain to be used is between 1000 and 6000 U, whereas only 2000 to 4000 pKat is recommended for treatment of a single disk. Much space is taken up with summarizing
Asymptomatic hypercholesterolaemia.
Authors: D P Gray, R Steele, K Sweeney, P Evans
Journal: BMJ (1991)

much the same way as advocated for cataract surgery.Such a policy avoids the disorientating effects of a hospital admission and allows elderly patients to return to familiar surroundings as soon as possible.I agree with the authors that patients need to be fully informed about available treatments.They should also be told that, in this instance, opting for surgery need not necessarily entail being subjected to either general anaesthesia or inpatient admission.
Abstract 4893: EGFR signaling controls the chromatin binding status of BMI1 through a CK2/PP1 phosphorylation/dephosphorylation pathway and affects astrocytoma proliferation and neural stem cell differentiation
Authors: Jessica Hawes, Robert Tuskan, Keiko Akagi, Karlyne Reilly
Journal: Cancer Research (2010)

Abstract Studies of brain tumors demonstrate the importance of a rare tumor cell population with the capability of regenerating tumors upon transplantation. These cancer stem cells (CSC) are believed to be more resistant to therapy than the bulk of brain tumor cells. Studies in mouse brain tumor models demonstrate that neural stem cells (NSC) can be an important initiating cell type for brain tumors, but it is unclear what is the relationship between NSC and CSC. EGF is a critical growth factor for NSC maintenance in culture and EGFR signaling is upregulated in glioblastoma. Similarly, the chromatin modulator BMI1 is necessary for NSC maintenance, and has been implicated in glioblastoma. We present studies linking cell surface EGF signaling and nuclear BMI1 chromatin binding. We demonstrate that BMI1 is specifically phosphorylated by EGFR signaling using EGF and TGFα, but not by many other oncogenic signaling ligands tested. We have identified three amino acids encompassing the phosphorylation site in response to EGFR signaling, and show that CK2 and PP1 are necessary for control of BMI1 phosphorylation. This phosphorylation alters the chromatin binding state of BMI1 and transcriptional regulation in astrocytoma cells. Interestingly we find that BMI1 can alter transcriptional profiles in both EGF-dependent and independent ways, suggesting that different signaling pathways could have specific effects on changing the BMI1-dependent epigenetic state of subsets of genes. Furthermore, EGF-induced phosphorylation of BMI1 is important for astrocytoma growth in vitro and in vivo, as well as maintenance of NSC. Our data link signals outside the cell to the nucleus important for NSC maintenance and astrocytoma proliferation. These data represent a common pathway in NSC and tumor cells that may explain the importance of EGF signaling for NSC maintenance and gliomagenesis, and suggest a novel downstream pathway (CK2/PP1) involved in these processes. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4893.
LSU and Tulane Suspended From NSABP Studies
Journal: JNCI Journal of the National Cancer Institute (1994)

LSU and Tulane Suspended From NSABP Studies Get access JNCI: Journal of the National Cancer Institute, Volume 86, Issue 10, 18 May 1994, Pages 750–751, https://doi.org/10.1093/jnci/86.10.750 Published: 18 May 1994
A Risk Model for Thrombocytopenia Requiring Platelet Transfusion After Cytotoxic Chemotherapy
Authors: J.Y. Blay, A. Le Cesne, C. Mermet, C. Maugard, A. Ravaud, C. Chevreau, C. Sebban, J.-P. Guastalla, P. Biron, I. Ray-Coquard
Journal: Blood (1998)