tbuckley/cabot-search huggingface dataset:
Mutagenic Activity of Phthalate Esters in Bacterial Liquid Suspension Assays
Authors: John L. Seed
Journal: Environmental Health Perspectives (1982)

The mutagenic activities of several phthalate esters have been evaluated in an 8-azaguanine resistance assay in Salmonella typhimurium. Three phthalate esters were found to be mutagenic: dimethyl phthalate, diethyl phthalate and di-n-butyl phthalate. A number of other phthalate esters were not found to be mutagenic, including di(2-ethylhexyl) phthalate, di-n-octyl phthalate, diallyl phthalate, diisobutyl phthalate and diisodecyl phthalate. A metabolite of di(2-ethylhexyl) phthalate, 2-ethylhexanol, was also noted to be mutagenic. The mutagenic activity of this agent and others in this series was dose dependent but weak. No dose-response curve exceeded more than 3.5 times background at maximally testable concentrations. A liquid suspension histidine reversion assay of dimethyl phthalate showed levels of mutagenic activity similar to that observed in the azaguanine resistance assay. The data suggest a need for further investigation of the mutagenic potential of these agents in other assay systems.
02.04 Sensitive spect/ct imaging of synovial fap expression after anti-il-22 treatment in experimental arthritis
Authors: Debbie M Roeleveld, Tessa van der Geest, Birgitte Walgreen, Monique M Helsen, Tapan K Nayak, Christian Klein, Martin Hegen, Peter Laverman, Otto C Boerman, Marije I Koenders
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Rheumatoid arthritis (RA) synovial tissue has been demonstrated to expresses high levels of fibroblast activation protein (FAP) using anti-FAP-antibody 28 H1. In addition, RA patients show elevated levels of IL-22 and IL-22-producing T helper cells that correlate to erosive disease, suggesting a role for this cytokine in RA pathogenesis. The purpose of this study was to determine the feasibility of <sup>111</sup>In-28H1 SPECT/CT imaging of FAP-expressing synovium to monitor the therapeutic potential of neutralising IL-22 during experimental arthritis. <h3>Materials and methods</h3> Collagen-induced arthritis (CIA) was induced in male DBA/1J mice. Mice were treated 3 times per week with anti-IL-22 antibodies (8 mg/kg), while the control group received rat IgG1 isotype control antibodies. To monitor the therapeutic effect after 2 weeks of treatment, SPECT/CT images were acquired 24 hours after injection of <sup>111</sup>In-labelled DTPA-conjugated anti-FAP antibody, 28 H1. After image acquisition, mice were euthanized and dissected. Imaging results were compared with the macroscopic arthritis scores, histological damage scores, and radiographic bone damage scores acquired by X-ray. <h3>Results</h3> Blocking IL-22 during CIA was a potent approach to prevent arthritis development, reaching a disease incidence of only 50%, versus 100% in the control group. SPECT/CT imaging using indium-labelled anti-FAP antibodies showed that joint uptake of the tracer was significantly reduced in anti-IL-22-treated mice compared to the isotype control group. This was confirmed by the corresponding macroscopic arthritis scores, histological damage scores, and radiographic bone damage scores that were significantly lower in the anti-IL-22-treated group. Besides its sensitivity, the <i>in vivo</i> FAP-based SPECT/CT had the great advantage to visualise sites of inflammation that were overlooked during clinical scoring, like in knee, hip, elbow, and shoulder. <h3>Conclusions</h3> These findings demonstrate that IL-22 plays an important role in the development of experimental arthritis, and targeting this cytokine seems an attractive new strategy in RA treatment. Most importantly, SPECT/CT imaging of the inflamed synovium using the labelled anti-FAP antibody <sup>111</sup>In-DTPA-28H1 can be used to specifically monitor response to therapy in an objective and quantitative way, and is potentially more sensitive in disease monitoring compared to the standard method of clinical arthritis scoring by macroscopic inspection.
AAMC Analyzes 1997 Balanced Budget Act
Authors: C. Marwick
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Upper airway obstruction after extubation
Authors: R. E. Johnstone
Journal: JAMA (1971)

A 23-year-old woman, apparently in good health, suddenly became unconscious and cyanotic four days postpartum. Improvement followed endotracheal intubation, but immediate respiratory distress and asphyxia occurred after extubation. Autopsy revealed laryngeal edema and a follicular thyroid carcinoma encasing the trachea. Emergency tracheotomy is necessary when intubation is not easily performed and the upper airway is obstructed.
Amer J Obstetrics &amp;amp; Gynecology, St. Louis
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Apace with pacemakers
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Money isn't everything. Nonfinancial barriers to access
Authors: E. Friedman
Journal: JAMA (1994)

WHETHER they take the form of managed competition, single-payer systems, regulated multipayer approaches, or expansion of Medicare and/or Medicaid, virtually all health care reform proposals share an underlying principle: that provision of coverage to the uninsured will ensure their access to care. (An exception is direct subsidy of hospital indigent care, which does not encourage structural change or make physician-based primary care available to the uninsured.) Unfortunately, the track record of American health care, especially in recent times, does not support the belief that coverage is equivalent to access. In the first place, all coverage is not created equal. For some theoretically insured groups, especially the Medicaid population, the availability of physician care is constrained,<sup>1-3</sup>and differences have been found in treatment patterns among patients with Medicare alone, Medicare and private supplemental coverage, and Medicare and Medicaid together.<sup>4</sup> Physicians' concerns about their financial viability following the introduction of
Section III. Pathology Review of Minimal Breast Cancers Detected in BCDDP
Journal: JNCI Journal of the National Cancer Institute (1979)

Section III. Pathology Review of Minimal Breast Cancers Detected in BCDDP Get access JNCI: Journal of the National Cancer Institute, Volume 62, Issue 3, March 1979, Pages 673–684, https://doi.org/10.1093/jnci/62.3.673 Published: 01 March 1979
Letter on Poor-law Medical Relief, and on the Order of the Commissioners
Journal: BMJ (1842)

a memoir on the sub- ject of lithrotrity, in cases complicated witlh retention of urine, and on a newimode of extractinig the frag- ments of calculi.For this purpose the author pro- posed the3 use of an instruiment wlhich he has invented, one portion of which allows of the escape of the detritus, while througlh the other a current of water is passed into the bladder.URETHROPLASTY.
First Catch
Authors: David Moolten
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effect of calcitriol on the production of T-cell-derived cytokines in psoriasis
Authors: M. BARNA, J.D. BOS, M.L. KAPSENBERG, F.G.M. SNIJDEWINT
Journal: British Journal of Dermatology (1997)

Although the use of vitamin D analogues in the treatment of psoriasis has been an important new development, the mechanisms of action of these drugs are not fully understood. Psoriasis results from hyperproliferation of keratinocytes, and various studies attribute a crucial role to the locally infiltrating T lymphocytes. In an attempt to add to the understanding of the mechanisms of calcitriol therapy, we determined the effect of this drug on T cells by studying its effect on proliferation and on the production of various cytokines by T‐cell clones prepared from psoriatic skin after non‐specific activation with the combination of phytohaemagglutinin (PHA) and phorbol myristate acetate (PMA). The addition of increasing doses (10‐9–10‐5mol/1) of caleitriol to these T cells resulted in a dose‐dependent inhibition in lymphocyte proliferation and in production of the type 1 cytokines IFN‐ γ and IL‐2. the type 2 cytokines IL‐4 and IL‐5. The general cytokines TNF‐α and GM‐CSF were not significantly inhibited. These data suggest that calcitriol is involved in the treatment of psoriasis via inhibition of the expansion, and cytokine production, of skin‐infiltrating T lymphocytes.
Sensitization of the Adrenal Cortex to Angiotensin II in Sodium-Deplete Man
Authors: WOLFGANG OELKERS, JEHOIDA J. BROWN, ROBERT FRASER, ANTHONY F. LEVER, JAMES J. MORTON, J. IAN S. ROBERTSON
Journal: Circulation Research (1974)

The effect of sodium depletion on the dose-response relationships of angiotensin II to aldosterone and blood pressure was studied. Arterial plasma angiotensin II and aldosterone and arterial blood pressure were measured before and during the incremental infusion of angiotensin II into sodium-replete and sodium-deplete subjects. Sodium depletion caused a distinct steepening of the angiotensin Il-aldosterone dose-response curves in four of five subjects and a concurrent diminution in the pressor effect of angiotensin II. Administration of angiotensin II did not demonstrably alter the half-life of aldosterone. Sodium depletion did not change the plasma concentrations of sodium or potassium, but it was accompanied by a significant increase in plasma levels of 11-hydroxycorticosteroids and magnesium. The contrasting effects of sodium depletion on the aldosterone and the pressor dose-response curves favored sodium retention. These results are consistent with an important role for the renin-angiotensin system in the control of aldosterone secretion in man.
AUTHORS' REPLY
Authors: G. Semenzato, C. Agostini
Journal: Thorax (1995)

The authors then state that "it has also been observed that HIV-1 detection in BAL fluid samples is significantly associated with progression to death but not to reduction of pulmonary function tests."Again our results were from patients with AIDS and the reason for the lack of correlation between these two parameters could be due to a masking by the concomitant opportunistic respiratory in- fection.It is well established that PCP has a profound effect on the carbon monoxide transfer factor (TLCO) in HIV-1 seropositive individuals."We reiterate that all our patients
Malaria and Glucose-6-phosphate Dehydrogenase
Authors: T. Wilson
Journal: BMJ (1961)

A 3.5-year-old girl presented with skin lesions beginning as a small pustule that progressed to very painful large ulcer with rolled up edges and irregular borders. At presentation, active ulcers were present over the left elbow. There were healed ulcers with scarring present on the chest, back, both thighs and abdominal wall. This child had negative antinuclear antibody, cytoplasmic antinuclear cytoplasmic antibody, antiphospholipid antibodies and tests for hepatitis B and C. She did not have any symptoms to suggest ulcerative colitis. Her colonoscopy was absolutely normal. Histopathology from her skin lesion was consistent with pyoderma gangrenosum.
THE INDICATIONS FOR LITHOTOMY.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Erratum: Lbx1 and Tlx3 are opposing switches in determining GABAergic versus glutamatergic transmitter phenotypes
Authors: Leping Cheng, Omar Abdel Samad, Yi Xu, Rumiko Mizuguchi, Ping Luo, Senji Shirasawa, Martyn Goulding, Qiufu Ma
Journal: Nature Neuroscience (2005)
PARIS
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Changes in Medical Journals.
Journal: JAMA (1883)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medical Center Health
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reply
Authors: S N Gyde
Journal: Gut (1991)

target biopsy specimens can be obtained from an abnormal area.It is true that a small proportion of patients develop carcinoma in colitis without dysplasia elsewhere in the colon and that dysplasia, when present, is usually patchy.The paper by Rasonhoff et al, however, is quoted as evidence that dysplasia at a distance from the cancerous lesion occurs in only 50% of colectomy speci- mens.This paper was based on histological blocks from only 22 specimens with cancer in colitis, complete resections were performed in only 11 of the patients, and more than five blocks were available from only 13 of the specimens.Some dysplasia at a distance from the tumour was found in 73% of specimens and high grade dysplasia in 50%.The authors suggest that one reason why the incidence of dysplasia was less than in other reports may have been due to limited sampling.Careful examination of 62 colectomy specimens with cancer in colitis at St Mark's Hospital has shown dysplasia at a distance from the tumour in 87%.Dr Gyde selected three clinical studies for comment and we appreciate her remarks about the importance of high levels of follow up and of clinical care in regard to our surveillance programme.It is a pity that she made no reference to two excellent Swedish series,4 one recently updated,6 in which there has been no cancer death and in which the three tumours treated surgically were at an early stage (Dukes's A).Like Dr Gyde, we would welcome the development of a new marker of neoplastic potential in colitis.Apart possibly from analysis of aneuploidy, which is complex and expensive, no such marker has been identified.Despite its limitations, dysplasia is still the only thoroughly tested marker we have and it should not be rejected.
Compelled medical treatment of pregnant women. Life, liberty, and law in conflict
Authors: L. J. Nelson
Journal: JAMA (1988)

AS RECENTLY stated by the ethics committee of the American College of Obstetricians and Gynecologists, the maternal-fetal relationship is a "unique one" as it involves "two patients with access to one through the other."<sup>1</sup>In no other situation is the physician faced with one patient literally inside the body of another patient. Conceptually, the medical care of each can be approached independently, but practically, neither can be treated without affecting the other. Because of this unique relationship, conflicts between the interests of the woman and the fetus can arise if the former refuses treatment recommended for the benefit of the latter (eg, refusing cesarean section for documented fetal distress and anoxia) or if she is unwilling or unable to change behaviors that potentially could harm her fetus, such as smoking, consuming alcohol, eating inadequately, or engaging in certain job-related or recreational activities. Kolder et al<sup>2</sup>recently documented a