tbuckley/cabot-search huggingface dataset:
Phase I/II study of docetaxel, capecitabine and carboplatin in metastatic esophagogastric cancer
Authors: J. Y. Tsai, A. Berkenblit, P. Akerman, A. Nadeem, R. Rathore, D. Harrington, D. Roye, K. Stuart, T. A. Kennedy, H. Safran
Journal: Journal of Clinical Oncology (2004)

4035 Background: Docetaxel, cisplatin, and fluorouracil (5-FU) achieved a survival advantage in a phase III gastric cancer trial by Ajani et al. Thymidine phosphorylase converts capecitabine to 5-FU. Docetaxel increases thymidine phosphorylase. We initiated a phase I/II trial of docetaxel (D), capecitabine (X) and carboplatin (C) for first line treatment for patients with metastatic esophageal and gastric cancer. Methods: Patients receiving first line therapy for metastatic gastric and esophageal cancer were eligible. Patients relapsing after previous adjuvant or neoadjuvant therapy were also eligible. Patients received docetaxel, 35–40 mg/m2, on days 1 and 8; carboplatin, AUC = 2, on days 1 and 8; and capecitabine 500-2000 mg/m2/day for 10 days, over five dose levels as shown below. Cycles were repeated every 21 days. Results: 27 patients have been enrolled. Data is available on the first 19 patients. Seven patients had previous neoadjuvant or adjuvant chemotherapy. There were no dose limiting toxicities (DLTs) in the first 2 cycles of treatment. However, due to cumulative myelosuppression, escalation beyond dose level 5 was not attempted. Seven of the 12 chemonaive patients responded (58.3%), and 5 of the first 7 patients treated at the final dose level responded (71.4%). Conclusions: Docetaxel, 40 mg/m2, and carboplatin AUC = 2, on day 1 and day 8 with capecitabine 2000 mg/m2 x 10 days is an easily administered, well tolerated regimen for patients with metastatic gastric and esophageal cancer. Promising preliminary activity has been demonstrated. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Aventis; Roche Laboratories; Genentech
Books Received.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
DERMATOLOGICAL SOCIETY OF GREAT BRITAIN AND IRELAND
Journal: British Journal of Dermatology (1901)

British Journal of DermatologyVolume 13, Issue 3 p. 102-103 DERMATOLOGICAL SOCIETY OF GREAT BRITAIN AND IRELAND First published: March 1901 https://doi.org/10.1111/j.1365-2133.1901.tb16364.xAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume13, Issue3March 1901Pages 102-103 RelatedInformation
Long Term Follow-Up of a Randomized Trial Comparing Response Adapted (RA), Non-Cross Resistant Induction and Consolidation with Idarubicin/Cytarabine (IDAC) Followed by Mitoxantone/Etoposide (NOVE) Compared with Consolidation with High Dose Cytarabine (HDAC) in Adult Patients with AML. A Study by the Canadian Leukemia Studies Group (CLSG).
Authors: Richard H. Van der Jagt, K. Robinson, D.P. Sheridan, R. Delage, L.M. Larratt, L. Yetisir, G. Wells
Journal: Blood (2006)
Artificial Skin
Authors: J. T. Schulz III, R. G. Tompkins, J. F. Burke
Journal: Annual Review of Medicine (2000)

The skin is a complex organ that is difficult to replace when it is irreversibly damaged by burns, trauma, or disease. Although autologous skin transplantation remains the most common form of treatment in patients with significant skin loss, there are now a number of commercially available products that can be used to replace the skin temporarily or permanently. Here we describe several such products under the rubric "artificial skin," focusing on two types of technology that have been applied to the problem of permanent skin replacement.
Venturesome toothpick. A continuing source of pyogenic hepatic abscess
Authors: D. B. Bloch
Journal: JAMA (1984)

IN MOST instances, following their accidental ingestion, toothpicks, like other foreign bodies, may pass through the gastrointestinal tract without inducing injury.<sup>1</sup>In the minority of cases, toothpicks may perforate the bowel wall and produce local or widespread peritonitis and abscess formation.<sup>1,2</sup>The site of perforation is usually in the ileum, appendix, or colon.<sup>1</sup>Occasionally, hepatic abscess may result from metastatic spread of infection via the portal vein.<sup>3</sup>In a few cases, perforation has occurred in the wall of the stomach or duodenum, and the toothpick has then perforated the inferior vena cava<sup>2</sup>or migrated to the liver and induced a pyogenic abscess.<sup>4</sup>This report concerns an additional (third?<sup>5</sup>) example of the latter event in which appropriate diagnosis was complicated by findings suggestive of an acquired immunodeficiency. <h3>Report of a Case</h3> A 56-year-old white male barber was admitted to Stanford (Calif) University Hospital for
Detection of Persistent <i>Helicobacter pylori</i> Infection
Journal: Annals of Internal Medicine (2002)

Summaries for Patients19 February 2002Detection of Persistent Helicobacter pylori InfectionSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-136-4-200202190-00003 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Helicobacter pylori (H. pylori) is a common type of bacteria that people usually get infected with during childhood. In most cases, the infection does not cause symptoms. However, some people with H. pylori infection eventually develop inflammation of the stomach (gastritis) or ulcers in the stomach or upper small intestine. Gastritis and ulcers cause abdominal pain and, sometimes, bleeding. Doctors often treat gastritis and ulcers caused by H. pylori with a combination of several antibiotics that are given for several days. Treatment gets rid of H. pylori in ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “The Stool Antigen Test for Detection of Helicobacter pylori after Eradication Therapy.” It is in the 19 February 2002 issue of Annals of Internal Medicine (volume 136, pages 280-287). The authors are D Vaira, N Vakil, M Menegatti, B van't Hoff, C Ricci, L Gatta, G Gasbarrini, M Quina, JM Pajares Garcia, A van der Ende, R van der Hulst, M Anti, C Duarte, JP Gisbert, M Miglioli, and G Tytgat.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe Stool Antigen Test for Detection of Helicobacter pylori after Eradication Therapy Dino Vaira , Nimish Vakil , Marcello Menegatti , Ben van't Hoff , Chiara Ricci , Luigi Gatta , Giovanni Gasbarrini , Mario Quina , Jose M. Pajares Garcia , Arie van der Ende , Rene van der Hulst , Marcello Anti , Cristina Duarte , Javier P. Gisbert , Mario Miglioli , and Guido Tytgat Metrics 19 February 2002Volume 136, Issue 4Page: I-36KeywordsAbdominal painAntibioticsAntigensBiopsyEndoscopyGastritisHelicobacter pyloriSmall intestineStomachUlcers ePublished: 19 February 2002 Issue Published: 19 February 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
THE DEAD LINE IN SPORTS.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A COUNTRY DOCTOR.
Authors: THOMAS H. SHASTID
Journal: JAMA (1897)

later.Gradually, the intervals between the visits are lengthened, until they are made every two, three or four months.The treatment can not be considered as complete under a year, since this length of time is considered necessary to observe all the variations to which the nervous system is subject.In favorable cases, patients stop drinking from the commencement of treatment.If they continue after the third sSance or commence during treatment, it is regarded as a proof that good results are not to be expected and that ' suggestion' is unavailable as a remedy."With suggestion M. Tokarsky employs strychnin in .
American Pharmacy: Fundamental Principles and Practices, Pharmaceutical Preparations. [Volume I]
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Insulin
Authors: Joseph R. Thurn
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Expanding the horizons of foodborne listeriosis
Authors: W. F. Schlech
Journal: JAMA (1992)

A little over 10 years ago, infections caused by the gram-positive coccobacillus<i>Listeria monocytogenes</i>were rare events, providing grist to the mill of grand rounds at university medical centers and case reports to medical journals.<sup>1</sup>Small clusters of temporally related neonatal infections occasionally piqued the curiosity of epidemiologists from the Centers for Disease Control and others,<sup>2,3</sup>but investigations of these clusters shed little light on the transmission of this pathogen. Investigators were stymied by the small number of cases in each cluster, and at the Centers for Disease Control, listeriosis came to be known as the "graveyard of epidemiology"! This situation changed radically in 1979 when a large outbreak of nosocomial listeriosis in Boston, Mass, city hospitals suggested the possibility of foodborne illness.<sup>4</sup>Foodborne transmission was finally confirmed by an outbreak of community-acquired perinatal and adult listeriosis traced to ingestion of contaminated cabbage from a farm on
Predicting the predisposition to osteoporosis. Gonadotropin-releasing hormone antagonist for acute estrogen deficiency test
Authors: R. Abbasi
Journal: JAMA (1986)

A reliable predictive test to identify perimenopausal women who are vulnerable to the adverse effects of severe estrogen deficiency may be useful in deciding for whom and when to begin estrogen replacement therapy. Primate models were employed to determine (1) whether short-term treatment with gonadotropin-releasing hormone antagonist allows prospective identification of individuals at greatest risk for a negative calcium balance during overt estrogen deficiency; (2) whether high-dose clomiphene citrate is sufficiently estrogenic to abate urinary calcium loss and to sustain vaginal and perineal tissues after ovariectomy; and (3) whether clomiphene citrate will provide these beneficial estrogenic effects without inducing endometrial proliferation and menstruation after progestin withdrawal. The data indicate the capability of short-term gonadotropin-releasing hormone-antagonist test to identify individuals likely to lose calcium rapidly after ovariectomy. This result has potential usefulness in the prediction of susceptibility to osteoporosis after medical castration or spontaneous menopause. At high doses, clomiphene citrate therapy was nearly as effective as high-dose conjugated equine estrogens for conservation of urinary calcium, yet clomiphene citrate did not cause endometrial proliferation or withdrawal bleeding after progesterone therapy. (<i>JAMA</i>1986;255:1600-1604)
The Local Government Bill and the Constitution of the Metropolitan Sanitary Districts
Journal: BMJ (1894)

SomE of the objections whiclh have been raised to the prac- tice of cremation are purely selntimental, and about these we wvill mnake no remark; the practical objections mostly re- solve themselves into questions of engineering and expense except ill regard to one point, niamely, the destructioln by the process of all traces of poisol, violence, or criminal ne- glect.This is the difficulty that hias to be faced.The Select 1onmmittee on Death Certification took evidence on this point, alild especially in rieference to the precautions taken by the Crnemation Society before a bodlv is cremated by tllem.It ,appears that two special certificates of the cause of deathi are obtained in suclh cases, that onie of these sets forthl that " there are Ino circumstances connecte(l w-ith the dleatlh which could make exlhumation of the body hereafter necessary ;" that if these are inconclusive a post-mortemn exaimiination is ordered, and that if the relatives object, the Society refuses to crenmate the body.Even if the body is eventually cre- mated, whenever there is aniytliing doulbtful about the case portions of the liver, kidney, and stoniaclh are retained and preserv'd in spirit.The Committee give their verdict on the subject very plainly.They "are of opinlionl that with tIme precautions
Renal Hypertension with Elevated Aldosterone
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Journal of Lipid Research, New York
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Increased sinusoidal wall permeability and liver fatty change after two-thirds hepatectomy: An ultrastructural study in the rat*1, *2
Authors: E MORSIANI
Journal: Hepatology (1995)

Accumulation of lipids in the hepatocyte cytoplasm after partial hepatectomy (PH) has long been recognized, but the mechanism behind this phenomenon is still poorly understood. In this study, rats subjected to a standard two-thirds PH showed early and marked increase in portal venous pressure (P <.01). On scanning electron microscopy, the regenerating liver fixed by portal perfusion under hemodynamic conditions identical to that found in vivo during the first 24 hours showed a significant (P <.01) 10-fold increase in the sinusoidal wall porosity (percentage open area by fenestrations). This was paralleled by the disappearance of the sieve-plate arrangement of small fenestrations and by a significant decrease in the number of fenestrations per micrometers squared of sinusoidal surface at 6 (P <.01) and 12 hours (P <.05). In addition, there were major changes in the frequency and distribution of all three classes of fenestrations. At 6 and 12 hours, there was a marked decrease of small class 1 fenestrations and a marked increase of intermediate class 2 fenestrations and large class 3 fenestrations (P <.0001). A concurrent accumulation of lipid droplets in the hepatocyte cytoplasm produced a 20-fold increase in the hepatocyte total lipid volume. A statistically significant linear correlation (r = 0.907; P <.01) was found between the amount of intracellular lipids and the data quantitating the changes in porosity of liver sinusoids at 24 hours. It is concluded that an increased sinusoidal wall permeability to lipids may be the primum movens in the pathogenesis of transient liver fatty change after PH in the rat.
Gray's Anatomy. Descriptive and Surgical. New American from the 15th English edition. Revised, enlarged and rewritten
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal