tbuckley/cabot-search huggingface dataset:
Tissue banking in midst of 'revolution of expansion' as more uses are found for various transplants
Authors: T. F. Kirn
Journal: JAMA (1987)

RECENTLY, there have been three well-publicized reports of infections transferred to patients from cadaver and donor tissues used for various procedures: Creutzfeldt-Jakob disease from a dura mater graft; hepatitis B from donor sperm; and finally, acquired immunodeficiency syndrome (AIDS) from a skin graft, reported in Britain (<i>JAMA</i>1987;257:1036-1037 [see also<i>JAMA</i>1986;255:581-584, 587] and this issue,<i>Leads From the MMWR; JAMA</i>1987;257:1079-1081, 1093-1094;<i>Am Med News</i>, March 13, 1987, p 51). Despite this clustering, tissue-transplantation specialists maintain that infections transmitted to a patient from allogeneic tissue are rare. However, those reports are, in a variety of ways, symptomatic of the current situation in tissue use and banking. The fact that they are of general interest to the medical community signifies the growing importance of tissue transplantation. "Tissue banking is going through a real revolution," says Joseph Matthews II, MD, cochair of the Standards Committee of the American Association of Tissue Banks
Leads from the MMWR. Pertussis--Maryland, 1982
Journal: JAMA (1983)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Points: Non-specificity of surfactant deficiency in neonatal respiratory disorders
Authors: D K James
Journal: BMJ (1984)

Phosphaturic mesenchymal tumors (PMTs) are neoplasms associated with tumor-induced osteomalacia. Patients typically present with pathologic fractures in the setting of chronic hypophosphatemic hyperphosphaturic osteomalacia, as well as gradual muscle weakness, bone pain, and difficulty walking. Because of their rarity and nonspecific symptomatology, phosphaturic mesenchymal tumors often go undiagnosed for years. Even when discovered on imaging, the tumors can be diagnostically challenging for radiologists. Phosphaturic mesenchymal tumors often tend to be small and can be located nearly anywhere in the body, and, therefore, can mimic many other tumors. This case highlights the imaging and pathologic markers of a phosphaturic mesenchymal tumor, often found in a patient with tumor-induced osteomalacia.
Neuroprotective Effect of Mild Hypothermia in Patients Undergoing Coronary Artery Surgery With Cardiopulmonary Bypass
Authors: Howard J. Nathan, George A. Wells, Janet L. Munson, Denise Wozny
Journal: Circulation (2001)

Background Neuropsychological deficits occur in 30% to 80% of patients undergoing heart surgery and are due in part to ischemic cerebral injury during cardiopulmonary bypass. We tested whether mild hypothermia, the most efficacious neuroprotective strategy found in laboratory studies, improved cognitive outcome in patients undergoing coronary artery surgery. Methods and Results Patients 60 years or older scheduled for coronary artery surgery were enrolled. During cardiopulmonary bypass, patients were initially cooled to 32°C then randomly assigned to rewarming to 37°C (control) or 34°C (hypothermic), with no further intraoperative warming. Testing was scheduled preoperatively and 1 week and 3 months postoperatively. Eleven tests were combined into 3 cognitive domains: memory, attention, and psychomotor speed and dexterity. A patient was classified as having a cognitive deficit if a decrease of ≥0.50 SD was realized in 1 or more domains. The incidence of cognitive deficits 1 week after surgery, which was the primary outcome, was 62% ( \batchmode \documentclass[fleqn,10pt,legalpaper]{article} \usepackage{amssymb} \usepackage{amsfonts} \usepackage{amsmath} \pagestyle{empty} \begin{document} \(\frac{62}{100}\) \end{document} ) in the control group and 48% ( \batchmode \documentclass[fleqn,10pt,legalpaper]{article} \usepackage{amssymb} \usepackage{amsfonts} \usepackage{amsmath} \pagestyle{empty} \begin{document} \(\frac{45}{94}\) \end{document} ) in the hypothermic group (relative risk 0.77, P =0.048). In the hypothermic group, the magnitude of deterioration in attention and in speed and dexterity was reduced by 55.6% ( P =0.038) and 41.3% ( P =0.042), respectively. At 3 months, the hypothermic group still performed better on one test of speed and dexterity (grooved pegboard). There was no difference in morbidity or mortality. Conclusions Our findings support a neuroprotective effect of mild hypothermia in patients undergoing coronary artery surgery and should encourage physicians and perfusionists to pay careful attention to brain temperature during cardiopulmonary bypass.
Influenza Activity—Worldwide, 1990-91
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Books Received
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Oxygen therapy equipment.
Journal: BMJ (1967)

anaemia, eosinophilia, and retardation of growth.'0This new syndrome has been delineated on the basis of clinical features, gastrointestinal radiography, intestinal biopsies, and favour- able response to corticosteroid therapy.The last distinguishes it in this age group particularly from intestinal lymphangiectasia, coeliac disease, and hypogammaglobulinaemia.T. A. Waldman and colleagues'0 propose the term allergic gastroenteropathy to delineate their series of cases because milk aggravated the protein-losing gastroenteropathy.Pre- cipitating antibodies to milk were detected in the serum of three patients.The patients improved on a milk-free diet and relapsed when milk was reintroduced.The favourable response to the administration of corticosteroids, together with clinical signs of asthma, eczema, and rhinitis, all contributed to the concept of an allergic gastroenteropathy.This series of six children comprised four boys and two girls.The age at onset of oedema was under 3 years in all but one child.Oedema was most marked in the periorbital area.Gastrointestinal symptoms included diarrhoea and vomiting after milk; but lactose tolerance tests were normal.Gastrointestinal x-ray examinations showed mucosal oedema of the small bowel in four and puddling and segmentation of barium in one patient.The authors are confident that this distinctive syndrome is not attributable to any of the previously recognized conditions that give rise to excessive loss of protein into the gastrointestinal tract, and that a trial of treatment with a milk-free diet or with corticosteroids is worth while.Hitherto the clinical patterns of disease associated with loss of protein have been classified according to whether the lesion is outside or inside the gastrointestinal tract: in the heart, liver, or pancreas, or in the stomach, small intestine, or the colon.We must now also keep in mind gastro- intestinal allergens, whether food or drug, which may contri- bute in turn to this gastrointestinal upset, metabolic disorder, and systemic disease, for early recognition is the first step away from the label "idiopathic oedema " and towards a rational basis of treatment.Correction of protein-losing gastroenteropathy has followed surgical treatment of constrictive pericarditis and other cardiac abnormalities.' Gastrectomy for giant hypertrophy of the gastric ruga'e has effected a cure, and so has putting gluten-allergic patients on a gluten-free diet.Corticosteroid therapy has proved beneficial in ulcerative colitis, and now also for milk-allergy protein-losing gastroenteropathy.
Teaching of Undergraduate Psychiatry in North America and Its Implications for the United Kingdom
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Text-book for Training Schools for Nurses, including physiology and hygiene and the principles and practice of nursing.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Proceedings of the British Thoracic Society
Authors: G Marks, P Burney, C Parry, C Connell, J Corkill, R Cunningham, E Ridgway, A Rigby, R White, R Smith, N French, R Wong, Crk Hind, R Chan, L Hemeryck, J Feely, L Clancy, S Lewis, D Richards, N Butiler, J Bynner, J Br1tton, S Johnston, M Campbell, P Patremore, S Smith, G Sanderson, S Myint, D Tyrreil, S Holgate, Meecham Dj, E Jones, C Paul, J Grahame-Clarke
Journal: Thorax (1993)

From 1938 to 1939 mortality due to lobar pneumonia fell by 32%.This was attributed to the commencement of widespread use of sulphonamides during 1939.However, this dramatic short- term reduction is small compared to the 100-fold reduction in mor- tality from this condition in young adults during the course of this century.The decline in mortality from lobar and pneumococcal pneumonia has continued well beyond the time when the use of antibiotics became widespread.We examined the role of cohort fac- tors in this decline using the OPCS' historical mortality data files.Age and sex specific death rates for lobar pneumonia (ICDs 2 to 7, 1911 to 1967) and pneumococcal pneumonia (ICDs 8 and 9, 1968 to 1990) were plotted by year of death (period) and year of birth (cohort) for subjects aged 15 to 64 years.Age-period-cohort analysis using iteratively reweighted least squares regression showed that there were significant independent risks attributable to age, period and cohort effects (all p < 0-0001).The period-by-age plots showed a decreasing risk of death over time in all age groups, with higher death rates and a slower rate of decline in the older age groups.The cohort-by-age plot, however, showed that this apparent interaction between age and period may represent a cohort effect.Plots of mor- tality rate by year of birth for each age group all declined steeply and were superimposed on each other.Since age at death, period of death and cohort of birth are linearly related, analysis cannot distinguish an effect due to an age-period interaction from a simple cohort effect, however, the latter is a more parsimonious explana- tion.The presence of a cohort effect implies that developmental or environmental factors which influence the risk of acquiring or succumbing to lobar or pneumococcal pneumonia have played an important part in reducing mortality from this disease.
Abstract 2335: Breast cancer cell-derived DNA activates STING pathway in macrophages
Authors: GaYoung LIM, Na-Lee Ka, Mi-Ock Lee
Journal: Cancer Research (2019)

Abstract Cell-free DNA (cfDNA) has been studied to be a diagnostic and prognosic marker. In breast cancer, however, there have been few studies on the biological role of cfDNA in the tumor microenvironment. Thus, investigating a role of cfDNA released from cancer cells to the tumor microenvironment is important in order to understand cancer biology. In this study, we showed that free DNA was a mediator that elicited inflammation and activated stimulator of interferon genes (STING) signaling, an essential pathway in cytosolic DNA-associated innate immune reponses in breast cancer. First, we found that mRNA levels of pro-inflammatory cytokines were increased in THP-1 macrophage cells co-cultured with MDA-MB-231 breast cancer cells. Second, the amount of free double strand DNA derived from MDA-MB-231 cells culture media was much more than THP-1 cells. Third, there was little induction of STING pathway in response to exogenous DNA in MDA-MB-231 cells, suggesting that cancer cells may not be sensitive to exogenous DNA for activating STING pathway. In contrast, STING pathway was activated in response to exogenous DNA in THP-1 cells. Taken together, cancer cell-derived DNA could be a factor to induce inflammation through activating STING pathway in tumor-associated macrophages. Citation Format: GaYoung LIM, Na-Lee Ka, Mi-Ock Lee. Breast cancer cell-derived DNA activates STING pathway in macrophages [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2335.
Carboxyhemoglobin in volunteer blood donors
Authors: G. L. Davis
Journal: JAMA (1974)

Smoking by donors largely accounts for the greater than 5% carboxyhemoglobin (COHb) saturation found in 17% of blood units in a volunteer blood program. Low levels of COHb in donor blood are potentially dangerous to susceptible recipients, particularly patients with cardiorespiratory diseases, those in whom dilution of blood volume does not occur, and patients with coronary artery disease who are undergoing bypass surgery. Recommendations that blood donors not smoke for two hours prior to phlebotomy must be balanced against potential loss of smoking donors. Screening for COHb in blood to be transfused to susceptible recipients, labeling of smokers' blood, or both, should be considered. (<i>JAMA</i>230:996-997, 1974)
Cardiopulmonary resuscitation
Authors: H. L. Gibbons
Journal: JAMA (1993)

<h3>To the Editor.</h3> —The Heimlich maneuver has saved thousands of persons choking on food or other foreign bodies. American Heart Association (AHA) guidelines<sup>1</sup>recommend the Heimlich maneuver to save choking adults and children. However, these same guidelines (page 2259) read: "In the infant a combination of back blows and chest thrusts is recommended for relief of complete foreign-body airway obstruction. Although data are limited in this age group, Heimlich thrusts are not recommended because of fear that abdominal thrusts may cause potentially fatal laceration of the large and unprotected liver." There are no scientific studies supporting back blows or chest thrusts or known published case reports of infants saved by those methods. Of greater importance are the dangers of those techniques. Former Surgeon General C. Everett Koop<sup>2</sup>declared back blows and chest thrusts "hazardous, even lethal. A back slap can drive a foreign object even deeper into the
Conjunctivitis and Skin Erythema
Authors: William Halperin
Journal: JAMA (1978)

Eighty-one members of girls' basketball teams were exposed to ultraviolet light while sitting in the bleachers of a school gymnasium. A mercury high-intensity discharge lamp lighting the bleacher area had a hole in its outer envelope that allowed the emission of ultraviolet light. Sixty-nine (85%) of the 81 girls were affected; 49 (71%) had symptoms of conjunctivitis and 63 (91%) had symptoms of erythema. (<i>JAMA</i>240:1980-1981, 1978)
Experimentation in medical history-taking
Authors: D. W. Simborg
Journal: JAMA (1969)

The traditional dialogue technique used by physicians to obtain a medical history is time-consuming and cumbersome to record. The use of quesionnaires and automated devices to perform these functions for the physician is being tested by numerous investigators. These newer techniques have been shown to be superior to the physician's dialogue history in terms of providing a recorded data base of patient information for future retrieval. They also enable easy collection of statistical information about symptomatology in diseases. However, there is no information available as to whether they better enable the physician to make an assessment of the patient's condition with respect to initial diagnostic and therapeutic decisions. Thus, at this time, they cannot be considered as a substitute for the physician-obtained medical history.
Medical Organization.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Drought’s Influence on Typhus
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal