tbuckley/cabot-search huggingface dataset:
Army aeromedical evacuation procedures in Vietnam: implications for rural America
Authors: S. Neel
Journal: JAMA (1968)

Army aeromedical evacuation procedures in Vietnam provide service so that no soldier is more than 35 minutes away from a medical facility capable of giving definite, resuscitative life-saving treatment. The use of the helicopter as a life-saving vehicle has not yet reached its full potential. The experiences that the Army Medical Service has gained in utilization of helicopter ambulances can and should be translated to comparable civilian emergency health programs.
BTS/BLF Young Investigators Prize Symposium
Authors: S Birring, C Brightling, F Symon, S Barlow, A Wardlaw, I Pavord, F Chua, S Dunsmore, A Segal, J Roes, G Laurent, J Maguire, N Smith, V Kelly, M Ledson, M Walshaw, N Diar Bakerley, N Keaney, K Sridharan, I Taylor, H Clague, R Page, P Temblett, J Baker, F Macbeth, A Smith, P Donnelly, W Anderson
Journal: Thorax (2002)

We have recently reported an excess of cases of organ specific autoimmune diseases amongst patients with idiopathic chronic cough and have suggested that the cough may be due to homing of activated lymphocytes from the primary site of autoimmune inflammation to the lung.We tested this hypothesis in comparative immunopathology study of 19 patients with idiopathic chronic cough recruited over a two year period (mean age 54y, 79% female, mean duration of cough 2y), 11 healthy subjects and 14 patients with explained chronic cough of similar severity.Organ specific autoimmune disease was present in six of idiopathic cough patients (32%) but no normals/ explained cough subjects.All subjects had a bronchoscopy, bronchoalveolar lavage (BAL) and bronchial biopsy using standard techniques.We obtained cytospins from the BAL for a differential cell count and studied BAL T-cell status (CD4/8), activation (CD103, CD25, CD49a, HLA-DR) and chemokine receptors (CCR3,5,6,11, CXCR3) using 3-colour flow cytometry.Bronchial biopsies were embedded in glycolmethacrylate and immunohistochemistry for CD3,4,8 (lymphocytes), CD14 (monocytes), CD45 (leukocytes), CD56 (NK cells), EG2 (eosinophils), Neutrophil Elastase (neutrophils), AA1 (mast cells), Interferon-γ, IL5, 3H4(IL4) was performed.The mean (SEM) BAL differential lymphocyte count was 6.8 (1.3)% in normals, 15.1 (2.6)% in idiopathic cough (mean difference from normals 8.3%; 95% Confidence Interval 1.6 to 15.0; p<0.02) and 7.0(1.7)% in explained cough.The proportion of BAL T-cells expressing CD4 was similar in all three groups and there were no differences in activation status of T-cells or chemokine receptor expression.CD56 and IFNγ expression in biopsies (cells/mm 2 submucosa) were reduced in subjects with idiopathic cough compared to normals and subjects with explained cough (p=0.03 and 0.047: Kruskal-Wallis).EG2 and 3H4 expression were raised in explained cough (p=0.02& 0.03) but there were no differences in expression of CD3 and other markers between groups.In conclusion, we have made a novel observation of lymphocytic bronchoalveolar inflammation in patients with idiopathic chronic cough.The association with organ specific autoimmune disease suggests that this might be due to homing of activated lymphocytes from primary sites of autoimmune inflammation or a hitherto unrecognised autoimmune bronchitis.Further studies are required to investigate the interaction between T-cells and the cough reflex.T2
Tubuloreticular inclusions in neonatal lupus erythematosus
Authors: S. B. Levy
Journal: JAMA (1976)

Numerous tubuloreticular structures were seen on electron microscopic examination of involved and uninvolved skin of a neonate with lupus erythematosus. The patient had characteristic lupus skin lesions at birth that worsened for three months, and then gradually subsided. Their course was associated with systemic illness. Skin biopsy specimen was diagnostic. Direct immunofluorescence of the skin showed no abnormalities. Abnormal serological findings were noted in the mother, who had no overt clinical disease. The significance of these virus-like structures in lupus erythematosus is emphasized by the present case. (<i>JAMA</i>235:2743-2744, 1976)
<i>Erratum:</i> Vol. 68, No. 17
Journal: MMWR Morbidity and Mortality Weekly Report (2019)

In the report "Notes from the Field: Live Poultry Shipment Box Sampling at Feed Stores as an Indicator for Human Salmonella Infections -Michigan, 2016-2018," on page 407, the sentence "These findings corroborate previously published results that found a positive correlation between the Salmonella molecular strains found in shipment boxes and those serotypes associated with human illnesses (7)." should have been included at the end of the fourth paragraph.In addition, on page 408, the reference "7.Sharma A, Erdman MM, Munoz-Vargas L, Mollenkopf DF, Habing GG.Changes in the prevalence, genotypes and antimicrobial resistance phenotypes of non-typhoidal Salmonella recovered from mailorder hatchling poultry sold at US feed stores, 2013-2015.
EFFECT OF SULFONAMIDE DRUGS ON NATURAL IMMUNITY
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SELECTIONS.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PARIS
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue Access Provided by Chonnam National University JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account
Fossae
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
World medical assembly.
Authors: Briti Sh
Journal: BMJ (1967)

PointersLeukaemia: Survey in Greater London (p.755) gives " weak support " for clustering of leukaemia in children.Survey in Lewisham (p.759) finds no evidence of clustering of the disease in both adults and children.Leader at p. 750.Colonic Diverticulosis: Transit times of food residues studied radiographically were substan- tially shorter than normal in patients with diverticula or irritable colon syndrome (p.760).Study of prevalence of diverticulosis in healthy volunteers in the, Oxford area shows incidence of one in three in the over 60's with a female preponderance (p.762).Letter at p. 800.Leader at p. 751.Burned Hands: Small children grasping electric- fire elements sustain severe injury requiring prolonged treatment, and the importance of preven- tion of such accidents is emphasized (p.764).Common Cold: Half the volunteers inoculated with " new" respiratory virus developed colds, and half of these subjects showed rising titres of antibody against the virus (p.767).
Phase I study of the HSP90 inhibitor AUY922 in combination with capecitabine as treatment for patients with advanced solid tumors.
Authors: Johanna C. Bendell, Lowell L. Hart, Shubham Pant, Jeffrey R. Infante, Suzanne Fields Jones, Adil Mohyuddin, Patrick Murphy, Jeffrey Patton, William Charles Penley, Dana Shelton Thompson, Howard A. Burris
Journal: Journal of Clinical Oncology (2013)

475 Background: Heat shock protein 90 (HSP90) is a molecular chaperone involved in the maintenance and function of client proteins, many of which are integral to key oncogenic processes. AUY922 is a competitive inhibitor of HSP90, with demonstrated activity in a variety of preclinical models. Further preclinical evidence suggests potential synergy between inhibition of HSP90 and fluorouracil treatment (Burkitt et al. 2007). This phase I study was designed to determine the maximum tolerated dose (MTD) of AUY922 in combination with standard dose of capecitabine as treatment for patients with advanced solid tumors. Methods: Patients with refractory solid tumors for which capecitabine was an appropriate therapy received AUY922 with capecitabine in a standard 3+3 dose escalation. Capecitabine 1000mg/m 2 was administered twice daily for days 1-14 of 21-day cycles, with escalating doses of AUY922 administered by intravenous (IV) infusion on days 1, 8, and 15; the 6th dose level combined the MTD of AUY922 with capecitabine 1250mg/m 2 . Dose-limiting toxicities (DLTs), safety, and efficacy were evaluated. Results: 23 patients were treated at 6 dose levels: 22mg/m 2 (n = 3); 28mg/m 2 (n = 3); 40mg/m 2 (n = 3); 55mg/m 2 (n = 5); 70mg/m 2 (n = 3); 70mg/m 2 with capecitabine 1250mg/m 2 (n = 6). There were no DLTs observed until the 6th dose level (grade 3 diarrhea). Common adverse events (all grades) included: diarrhea (61%), nausea (57%), fatigue (43%), hand-foot skin reaction (39%), anorexia (39%), vomiting (35%), rash (30%), and darkening vision (22%). Myelosuppression was uncommon, with no instances of grade ≥3 thrombocytopenia, and only 2 patients (9%) with grade 3/4 neutropenia (1 patient each). Of the 19 patients evaluable for response per RECIST 1.1, unconfirmed partial response (PR) was noted in 3 patients (13%; colorectal, 1; breast, 1; stomach, 1), with 1 additional confirmed PR (4%; colorectal); two of these had progressed on prior fluorouracil. Stable disease was noted in 8 patients (35%). Conclusions: The addition of AUY922 to standard dose capecitabine was well-tolerated at doses of up to 70mg/m 2 . Preliminary efficacy is encouraging, and warrants further investigation of this regimen. Clinical trial information: NCT01226732.
The `Contradictions' of Coronary Flow
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Socioeconomic factors and the odds of vaginal birth after cesarean delivery
Authors: D. E. King
Journal: JAMA (1994)

<h3>Objective.</h3> —To determine the independent effect of socioeconomic, organizational, and professional liability factors on the odds of vaginal birth after cesarean delivery (VBAC) while controlling for important clinical factors. <h3>Design.</h3> —A retrospective study of 1989 New York State vital statistics data, supplemented with additional information on county- and hospital-specific variables. Using multiple logistic regression analysis, odds ratios (ORs) and 95% confidence intervals (CIs) were derived for 15 independent variables. <h3>Setting.</h3> —Births occurring in 104 New York State hospitals. <h3>Data Set.</h3> —A total of 13944 births occurring to New York State residents with a history of cesarean delivery of which 3068 (22%) were vaginal deliveries. <h3>Results.</h3> —The odds of VBAC increased with maternal education. The ORs were 1.15 (95% CI, 0.99 to 1.34) for 12 years of education; 1.36 (95% CI, 1.16 to 1.60) for 13 to 15 years; 1.59 (95% CI, 1.32 to 1.93) for 16 years, and 2.00 (95% CI, 1.64 to 2.45) for 17 years or more. The ORs also increased with the level of care provided by the hospital; they were 1.55 (95% CI, 1.34 to 1.81) and 1.30 (95% CI, 1.18 to 1.44) for hospitals with intensive and intermediate neonatal care facilities, respectively. The ORs were 1.15 (95% CI, 1.02 to 1.30) for health maintenance organization participants and 0.77 (95% CI, 0.63 to 0.94) for women giving birth in government hospitals. The ORs of VBAC for African-American and Hispanic mothers were 0.80 (95% Cl, 0.70 to 0.93) and 0.61 (95% CI, 0.51 to 0.73), respectively. The ORs for a $5000 increase in physician's yearly malpractice premium and the hospital's paid loss due to malpractice claim settlements were 0.98 (95% CI, 0.97 to 0.99) and 1.01 (95% CI, 0.99 to 1.03), respectively. <h3>Conclusions.</h3> —In addition to clinical factors, a mother's level of education and ethnicity and specific characteristics of the hospital in which she delivers affect the odds of a vaginal delivery after a previous cesarean delivery. From our analysis, we cannot conclude that professional liability factors affected VBAC rates. (<i>JAMA</i>. 1994;272:524-529)
Phase 3, randomized, double-blind, placebo-controlled study of PEGylated recombinant human hyaluronidase PH20 (PEGPH20)+nab-paclitaxel/gemcitabine in patients with previously untreated, hyaluronan-high, stage IV pancreatic ductal adenocarcinoma (PDA)
Authors: D-Y Oh, Y-J Bang, E. Van Cutsem, A. Hendifar, M. Reni, L. Zheng, M. Ducreux, W. Harris, P. Corrie, T. Seery, D. Chondros, A. Bullock, C-P Li
Journal: Annals of Oncology (2017)
Diagnosis of Comorbid Psychiatric Disorders in Substance Users Assessed With the Psychiatric Research Interview for Substance and Mental Disorders for DSM-IV
Authors: Deborah Hasin
Journal: American Journal of Psychiatry (2006)

Objective: The authors used the Psychiatric Research Interview for Substance and Mental Disorders for DSM-IV (PRISM-IV) to test the reliability of DSM-IV-defined disorders, including primary and substance-induced disorders, in substance-abusing subjects. Method: Substance-abusing patients (N=285) from substance abuse/dual-diagnosis treatment settings and mental health treatment settings participated in test and blind retest interviews with the PRISM-IV, which includes specific guidelines for assessment of substance abusers. Results: Kappas for primary and substance-induced major depressive disorder ranged from 0.66 to 0.75. Reliability for psychotic disorders, eating disorders, antisocial personality disorder, and borderline personality disorder was in the same range. Reliability for most anxiety disorders was lower. Reliability was good to excellent (kappas ≥0.65) for most substance dependence disorders. Continuous measures (severity, age at onset) had intraclass correlation coefficients >0.70 with few exceptions. Reliability was better for primary than for substance-induced disorders, although not greatly so. Conclusion: Most DSM-IV psychiatric disorders can be assessed in substance-abusing subjects with acceptable to excellent reliability by using specifically designed procedures. Good reliability improves the likelihood of significant study results.
Oxford Hesitates
Authors: A. D. Gardner
Journal: BMJ (1951)

<h3>Abstract</h3> Cross experiment comparisons in public data compendia are challenged by unmatched conditions and technical noise. The ADAGE method, which performs unsupervised integration with neural networks, can effectively identify biological patterns, but because ADAGE models, like many neural networks, are over-parameterized, different ADAGE models perform equally well. To enhance model robustness and better build signatures consistent with biological pathways, we developed an ensemble ADAGE (eADAGE) that integrated stable signatures across models. We applied eADAGE to a <i>Pseudomonas aeruginosa</i> compendium containing experiments performed in 78 media. eADAGE revealed a phosphate starvation response controlled by PhoB. While we expected PhoB activity in limiting phosphate conditions, our analyses found PhoB activity in other media with moderate phosphate and predicted that a second stimulus provided by the sensor kinase, KinB, is required for PhoB activation in this setting. We validated this relationship using both targeted and unbiased genetic approaches. eADAGE, which captures stable biological patterns, enables cross-experiment comparisons that can highlight measured but undiscovered relationships.
Superior vena caval obstruction due to small-cell anaplastic lung carcinoma. Response to chemotherapy
Authors: R. C. Kane
Journal: JAMA (1976)

Among 38 patients with bronchogenic carcinoma, small-cell type, eight patients had superior vena caval obstruction (SVCO) of recent onset. Seven of these patients were initially treated with combination chemotherapy (lomustine, cyclophosphamide, and methotrexate). One patient who had SVCO was treated initially by radiotherapy, with subsequent chemotherapy. In each patient, resolution of the syndrome was prompt, usually was complete by seven days, and was accompanied by objective tumor shrinkage. Symptoms of SVCO were transiently aggravated by the initiation of treatment in only one patient. In one individual treated by chemotherapy alone and in one treated by chemotherapy plus radiotherapy, SVCO recurred after initial control. Chemotherapy is an effective form of management of SVCO caused by small-cell carcinoma of the lung. (<i>JAMA</i>235:1717-1718, 1976)