tbuckley/cabot-search huggingface dataset:
Host Determinants of Response to Antimicrobial Agents
Authors: Louis Weinstein, A. Condon Dalton
Journal: New England Journal of Medicine (1968)

Genetic FactorsThe genetic background of patients may play a determinant part in the use of some antimicrobial agents. Although there may be other examples of this phenomenon, two outstanding ones are deficiency of glucose-6-phosphate dehydrogenase (G-6-PD) and differences in the rate and degree of hepatic acetylation of isoniazid. Both the results of treatment and the risk of reactions are determined, in some cases, by these genetic abnormalities. Failure to recognize their presence may result, on the one hand, in rapidly developing acute hemolytic anemia, and, on the other, in possible undertreatment of tuberculosis or the appearance of serious toxic . . .
Aftershock
Authors: Laurence J. Purdy
Journal: JAMA (1990)

The slippage came in mid-afternoon the last day of February. Directly below the hospital, under the alluvial fan of the San Gabriels, the crust of the earth heaved violently. The faults in this part of California run like veins of a leaf, unseen, miles beneath the surface. At any time, completely unexpected, they can undo freeways and skyscrapers and life, reconstruct the earth. Each time I look at the mountains, so close to the hospital and my home, the periphery of my thoughts is bothered by the quiescent power that created them. I had been in earthquakes before, strong ones, but safely far away from the epicenter. This time, standing on the second floor, directly over the epicenter, I was knocked off balance like a sailor in a storm. Time took on the dimensionless qualities of a dream, brief but endless enough for me to regard my life as fragile
SIMPLE PROTECTION FOR NEWLY PLACED SKIN GRAFTS
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Selected characteristics of black physicians in the United States, 1972
Authors: T. Thompson
Journal: JAMA (1974)

The profile of black physicians in the United States has not changed appreciably since 1967. A sample of 3,405 black physicians (91% male, 9% female) who responded to a mailed questionnaire survey shows that black physicians are more likely to concentrate in the fields of general practice, medical and surgical specialties, and solo practice as opposed to group practice than the universe of US physicians. Black male physicians are twice as likely to be in solo practice or self-employed than are black female physicians. Fee-for-service is reported as the primary source of income. (<i>JAMA</i>229:1758-1761, 1974)
INDIVIDUAL PHYSICAL MONITORING FOR ELITE WOMEN'S INTERNATIONAL SOCCER PLAYERS: AN EDUCATIONAL PROGRAMME
Authors: Stephen Boyce, Oliver Davies, Michael McKenna, Andrew White, Mark Dixon, Niall Elliott
Journal: British Journal of Sports Medicine (2017)

Background Education of soccer players is important in injury prevention and maintaining health throughout their career. Injury epidemiological studies have highlighted risk around knee and ankle. Aetiological factors include direct trauma, biomechanical imbalances, poor mobility, strength imbalances and training load. Objective To monitor individual player specific physical range of movement scores to inform and educate players around self-management, readiness to train and injury risk. Design Prospective observational study. Setting Scotland women's soccer national squad. Participants Elite women international soccer players. Interventions (or Assessment of Risk Factors) Players were assessed each morning during international team camps for a range of objective physical markers. Main Outcome Measurements Sit and reach distance, Knee to wall distance, Thomas test hip range of movement. Average scores were used to educate players and individually tasked with completing specific self-management modalities to improve these scores before entering a risk environment. Results 28 players completed the self-directed objective tests. The physical markers were averaged out and players given individual red, amber and green scores. The markers were discussed amongst the sports medicine team and concerns regarding a player's health and fitness relayed to the coaching staff. The player was tasked with completing self-directed individualised exercises to improve any flagged scores. They were also tasked with completing this in their club environment and improvement in physical markers scores was noted on subsequent camp entries. Conclusions Using specific physical markers individual to each player we were able to track and inform of any flagged scores during the health check. This enabled us to give a clear understanding of player readiness to train as well as informing and educating the player on how they could improve their scores through self-management modalities therefore decreasing injury risk. Initial findings through injury surveillance suggest a decrease in lower limb muscle related injuries.
Adolescent medicine
Authors: J. D. Klein
Journal: JAMA (1993)

Two health care policy areas precipitated by the political events of 1992 will have major impact on adolescents. The first, the proposed health care reform, will likely affect adolescents' access to health care and may change our country's approach to reproductive health issues and to human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) prevention. Second, comprehensive Guidelines for Adolescent Preventive Services (GAPS) were developed to establish multispecialty, interdisciplinary guidelines for a package of clinical preventive services addressing both the traditional physical problems as well as the behavioral and emotional problems experienced by today's youth. GAPS advocates a major expansion of the role of primary care health providers in health promotion and in the prevention of adolescent morbidity and mortality. The potential for optimizing adolescents' physical, psychological, and social health status, and our ability to provide necessary services toward these goals are highly dependent on the political climate. Adolescents' access to care, the
Minoxidil treatment of malignant hypertension. Recovery of renal function
Authors: F. C. Luft
Journal: JAMA (1978)

We treated eight severely hypertensive, long-term hemodialysis patients who failed to respond to ultrafiltration or conventional medication with minoxidil rather than with bilateral nephrectomy. Control of blood pressure and relief of symptoms was achieved in all eight. In addition, three of the patients, who were all severely oliguric, recovered sufficient renal function to allow the discontinuation of dialysis. Two are presently doing well, while one died of causes unrelated to uremia or minoxidil therapy. We presently reserve bilateral nephrectomy for those hypertensive dialysis patients who are awaiting transplantation. (<i>JAMA</i>240:1985-1987, 1978)
Glucocorticoid use and risks of ocular hypertension and glaucoma
Authors: M. D. Murray
Journal: JAMA (1997)

<h3>To the Editor.</h3> —The case-control study by Dr Garbe and colleagues<sup>1</sup>raises the concern that high-dose inhaled corticosteroid use could be associated with the ocular hypertension or open-angle glaucoma. Although the analysis controls for a number of putative confounding factors, one important confounder was not considered that could have important implications in the interpretation of the study results: the use of antihistamines. Many patients who use inhaled steroids regularly for reactive airways disease or allergic rhinitis also use antihistamines. Antihistamines have anticholinergic activity, which could increase intraocular pressure to dangerous levels in patients with angle-closure glaucoma or cause other vision complaints. The study investigators excluded patients with angleclosure glaucoma. However, given the margin of error contained within<i>International Classification of Diseases, Ninth Revision (ICD-9)</i><sup>2</sup>codes in claims data to distinguish between subsets of primary diagnoses<sup>3,4</sup>and the small effect observed for high-dose inhaled steroids in this study, failure to consider
Cannabis Roots
Authors: John R. Rodger
Journal: JAMA (1971)

<h3>To the Editor.—</h3> In all the current discussion about cannabis (marihuana), there is one effect I have never seen mentioned, ie, the digitalis-like effect of an extract of the root upon heart muscle. As a sophomore medical student at Ann Arbor, Mich, in 1931, I remembered stories an old uncle of mine in northern Michigan had told about the way Indians had used "Indian hemp" (the North American<i>Cannabis</i>) for treatment of persons afflicted with "dropsy." He had personally observed the profuse diuresis which occurred after the patient drank whiskey in which<i>Cannabis</i>roots had been soaked for some hours. I checked with one of the aging physicians in the area, who remembered how an Indian squaw had treated her husband with a watery extract of the hemp. "My patient died, and hers lived!" My uncle identified some roots for me to take to Ann Arbor. Dr. Edmunds, professor of
Intranasal Lidocaine for Treatment of Migraine
Authors: Merle L. Diamond
Journal: JAMA (1996)

<h3>To the Editor.</h3> —The suggested use of intranasal lidocaine 4% for the acute treatment of migraine is an interesting proposition that may offer hope as a useful analgesic option. However, the article by Dr Maizels and colleagues<sup>1</sup>did not clearly address the use and dosage of this medication. In high doses, lidocaine can cause significant morbidity, resulting in confusion, agitation, seizures, and cardiac dysrhythmias. Intranasal lidocaine can be absorbed systemically and could be potentially toxic if the patient uses the agent excessively. The risk for toxicity due to frequent use is underscored by the brief duration of action of lidocaine and the high recurrence rate of acute migraine. Also, the authors note the high relapse rate for headache early after treatment. Further studies are essential to determine safe and judicious prescription labeling of lidocaine for treatment of acute migraine.
Vitamin E therapy of acute CCl4-induced hepatic injury in mice is associated with inhibition of nuclear factor kappa B binding*1, *2
Authors: S LIU
Journal: Hepatology (1995)

Oxidative stress, with reactive oxygen intermediate formation, may represent a common mechanism by which liver injury is induced by diverse etiologies. Oxidative stress enhances nuclear factor kappa B (NF-κB) activity, and NF-κB activity has been shown to enhance the expression of cytotoxic cytokines. Acute hepatic injury caused by reactive oxygen intermediate production was induced by an intraperitoneal injection of CCl4 in mice. This injury was significantly inhibited by intravenous pretreatment of the mice with a water-soluble emulsion of α-tocopherol. Alpha-tocopherol treatment of the mice given the CCl4 also reduced the NF-κB binding to levels approaching those found in normal mice. In vitro treatment of a monocyte/macrophage cell line with CCl4 led to enhanced NF-κB binding and an increase in tumor necrosis factor-α (TNF-α) messenger RNA levels. Liver specimens taken from patients with acute fulminant hepatitis had markedly increased NF-κB binding activity in comparison with the binding of normal livers. These data demonstrate that abolishing acute hepatic injury with α-tocopherol, a free radical scavenger, also eliminated increased NF-κB binding. It is tempting to speculate that enhanced NF-κB expression caused by free radical production/oxidative stress may modulate liver injury, perhaps through an effect on cytotoxic cytokine synthesis.
Accidental strangulation from vest restraints
Authors: L. Katz
Journal: JAMA (1987)

<h3>To the Editor.—</h3> In their article, Dunn et al<sup>1</sup>find that house officers' attitudes regarding attire and etiquette are considered inappropriate by patients and they therefore recommend that physicians "adopt conservative habits to avoid displeasing a substantial segment of the patient population." Although differences in attitudes between physicians and patients may, as the authors point out, adversely affect the relationship that is essential for optimal care, their findings do not justify their recommendation. As the authors recognize, their findings represent only a segment of the population. Not surprisingly, it is the most conservative one, considering that the majority of the patients were middle-aged or older. Since the presumably inappropriate attitudes may be perceived differently by other segments of the population (children, for example, often perceive the white coat as threatening, while adolescents and teenagers usually feel more comfortable with somebody who dresses like them), it is hard to understand
Lipid Factors in Atherosclerosis
Authors: George J. Schroepfer
Journal: New England Journal of Medicine (1957)

(Concluded)Atherosclerosis in Human "Hypercholesterolemic Diseases"The high prevalence of atherosclerosis in certain states characterized by chronic abnormalities in lipid metabolism can be offered as circumstantial evidence that lipids are important in the pathogenesis of atherosclerosis.In 1851 Addison and Gull52 described peculiar lesions of the skin that have come to be known as xanthelasma and xanthoma tuberosum. Fagge,53 in 1873, pointed out fatty lesions in the aortas of persons afflicted with these skin lesions and stated, "it would be a matter of indifference whether we should speak of the cutaneous disease as an atheroma of the skin, or of . . .
Poetry and Medicine
Authors: Floyd Skloot
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Recollections of Work in an Ambulance
Authors: W. Mac Cormac
Journal: BMJ (1870)

and shortcomings were few in comparison with the magnitude and odiousness of the work which had to be undertaken.The disinfe cting apparatus of the Workhouse Hospital being adequate only to the patients located there, the town establishment, erected by the Corporation, was placed at the disposal of the vestry for the Kirkdale and Ashfield-street Hospitals.
The clinical course of diabetic nephropathy
Authors: M. J. Kussman
Journal: JAMA (1976)

A retrospective record analysis of 112 juvenile-onset diabetics with nephropathy was conducted in order to determine their clinical course. The mean duration of diabetes at the onset of proteinuria was 17.3±6.0 years. Early renal failure appeared two years after the onset of proteinuria, and severe renal failure (mean serum creatinine level, 8.5±3.9 mg/100 ml) four years after the onset of proteinuria. The mean duration of life after the onset of severe renal failure was six months. The mortality was 53%, with 59% of the deaths attributable to renal failure and 36% to cardiovascular disease. All patients experienced progressive deterioration of renal function as well as the other complications of diabetes, the rate of progression being accelerated toward the end of the course. Juvenile onset diabetics should be considered for renal transplantation before the serum creatinine level reaches 8.5 mg/100 ml. (<i>JAMA</i>236:1861-1863, 1976)
Abstract 3628: Neuronal Nitric Oxide Synthase (nNOS) Regulates Basal Flow in the Human Coronary Circulation I <i>n Vivo</i>
Authors: Mike Seddon, Phil Chowienczyk, Narbeh Melikian, Rafal Dworakowski, Barbara Casadei, Ajay Shah
Journal: Circulation (2008)

Endothelial NO synthase (eNOS) is thought to be the major source of nitric oxide (NO) involved in the local regulation of human vascular tone. However, in studies using a selective neuronal NOS (nNOS) inhibitor S-methyl-L-thiocitrulline (SMTC), we recently reported that basal human forearm blood flow is regulated by nNOS. SMTC had no effect on acetylcholine-induced vasodilatation which however was inhibited by the non-selective NOS inhibitor N G monomethyl-L-arginine (L-NMMA). This study investigated the effects of nNOS in the human coronary circulation in vivo . We studied patients undergoing diagnostic cardiac catheterisation who had angiographically normal coronary arteries. Coronary flow velocity was measured by an intracoronary Doppler wire and epicardial artery diameter by QCA. We compared the effects of intracoronary SMTC or L-NMMA infusion on basal flow and the responses to substance P and isosorbide dinitrate (endothelium-dependent and -independent dilators, respectively). L-NMMA (25 μmol/min) reduced basal coronary flow by 22.3±5.3% and inhibited dilation to substance P (20 pmol/min) by 57±5.7% (n=8; both P&lt;0.01). SMTC (0.625 μmol/min) also reduced basal flow (−34.8±6.3%; n=8; P&lt;0.01), but had no effect on the response to substance P (inhibited by −2±14%; P=NS). The effects of SMTC were abolished by L-arginine (240μmol/ min; n=3). Both L-NMMA and SMTC reduced epicardial artery diameter (−2.5±0.6% and −2.8±0.9% respectively; P&lt;0.05) but only L-NMMA reduced dilatation to substance P (5.6±1.3% before versus 3.0±0.8% after L-NMMA; P&lt;0.05). These data indicate that local nNOS-derived NO regulates basal coronary blood flow in humans in vivo , whereas substance P-stimulated vasodilatation is eNOS-mediated. Our results indicate that nNOS and eNOS have distinct local roles in the physiological regulation of human coronary vascular tone in vivo .
Insane: Sane
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction
Journal: BMJ (1954)

A JOUINAL intake of some 15 minims, and it is usually believed that in chronic arsenical poisoning skin manifestations precede toxic effects on the liver.After animal experiments prompted by the Manchester "epidemic" of arsenical poisoning in beer drinkers, Delepine3 concluded that a dose of 1/150 to 1/25 gr.(0.4 to 2.6 mg.) daily was capable of producing injurious effects in the ill-fed or weak individual The 1 minim dose of liquor arsenicalis contains about 0.6 mg. or 1 / 100 gr. of arsenic trioxide.The development of chronic arsenical poisoning depends on the dose, the form in which the arsenic is taken, the duration of exposure to riskrand any special susceptibility.It may be expected that the effects of alcohol, arsenic, infection, etc., may well be synergistic and lead to changes in the liver which might not occur with one agent alone.It is difficult to justify the inclusion of liquor arsenicalis in sedative mixtures, and in view of what has been said above it would be wiser not to prescribe for repeated use mixtures containing even such small quantities of a potenti- ally dangerous cumulative poison.
NICKEL ANTIBODIES*
Authors: LOUIS FORMAN, SUZANNE ALEXANDER
Journal: British Journal of Dermatology (1972)

Journal Article NICKEL ANTIBODIES Get access LOUIS FORMAN, LOUIS FORMAN Department of Medicine, Guy's Hospital, London, S.E.1 Search for other works by this author on: Oxford Academic Google Scholar SUZANNE ALEXANDER SUZANNE ALEXANDER Department of Medicine, Guy's Hospital, London, S.E.1 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 87, Issue 4, 1 October 1972, Page 320, https://doi.org/10.1111/j.1365-2133.1972.tb07417.x Published: 01 October 1972 Article history Accepted: 20 March 1972 Published: 01 October 1972
Leopard: A Phase II Study Of Post Autologous Stem Cell Transplantation (ASCT) Maintenance Lenalidomide and Prednisolone For Myeloma (MM), Incorporating Minimal Residual Disease (MRD) Assessments
Authors: Anna Kalff, Nola Kennedy, Patricia A. Walker, Marion Black, Odette Youdell, Malgorzata Gorniak, Tiffany T. Khong, Lona Estifo, Angela Smiley, Anthony P. Schwarer, Andrew W. Roberts, Philip Campbell, Robin Flishie, Andrew Spencer
Journal: Blood (2013)
Relapsing Polychondritis
Authors: N.R. ROWELL, J.A. COTTERILL
Journal: British Journal of Dermatology (2006)

Journal Article Relapsing Polychondritis Get access N.R. ROWELL, N.R. ROWELL University Department of Dermatology, The General Infirmary, Leeds Search for other works by this author on: Oxford Academic Google Scholar J.A. COTTERILL J.A. COTTERILL University Department of Dermatology, The General Infirmary, Leeds Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 88, Issue 4, 1 April 1973, Pages 387–390, https://doi.org/10.1111/j.1365-2133.1973.tb07570.x Published: 01 April 1973 Article history Accepted: 06 October 1972 Published: 01 April 1973