tbuckley/cabot-search huggingface dataset:
Pain Relief
Authors: Seymour Diamond
Journal: JAMA (1975)

<b>Pain: Research and Treatment, Further Observations From City of Hope Medical Center</b>, by Benjamin L. Crue, Jr, 417 pp, with illus, $26, New York, Academic Press, 1975. <i>Pain Relief</i>is an excellent primer and reference text for the practicing physician and should be of incalculable service in the management of obstinate pain problems. The volume consists of 178 pages broken up into 14 concise, inclusive, well-organized, and informative chapters. Each chapter concludes with a list of references and advice for further reading, making research efforts simple for the physician seeking in-depth knowledge. Hannington-Kiff presents current views about pain relief, adequately discusses basic theories of pain, presents structural plans for the management of various types of "-algia" and concludes with a promising look at future directions of pain therapy. He discusses the technique of taking a proper and detailed pain history and rightfully emphasizes its importance. A step-by-step outline of the
The diverse nature of cancer cells: one reason therapy can fail
Authors: C. Macek
Journal: JAMA (1982)

Although many cancer researchers believe that a cancer arises from a single aberrant cell, the same cancer may contain a diverse population of cells when it reaches a clinically detectable size. Recently, the implications of this heterogeneity for causes and treatment of primary cancers and metastases were discussed at a Bristol-Myers Symposium on Cancer Research held at The Johns Hopkins Oncology Center, Baltimore. "It is becoming apparent that tumor cells which look alike when stained and viewed under the microscope do not necessarily behave alike in the body," said Albert H. Owens, Jr, MD, head of the center and symposium director. "For example, some may metastasize while others won't; some may divide, others not; some may be sensitive to drugs, others resistant." According to Stephen B. Baylin, MD, associate professor of oncology and medicine at Johns Hopkins, it is possible to correlate the prognosis of patients having medullary thyroid cancer
Correction
Journal: BMJ (1944)

sclercsis and organic lhcart disease are also contraindications.Pro- longed nerve irritation when it occurs is more likely to be due to trauma or sepsis than to the injection.Endocrine Types and Measurements Q.-Certain anithropomiiorphic ineasurements-e.g., spani, vertex to pubis, plubis to heel, total height, circum71ference of head, chest, etc.-have been described by endocrinolog.stsfor the differenitiationi of em-docrine types.Are these measurements, and the types which are d'stinmguished fromii themn, of recognized signzificanice ?
Plasma sFas and sFas ligand levels in patients with thrombotic thrombocytopenic purpura and in those with disseminated intravascular coagulation
Authors: Yasuhide Hori, Hideo Wada, Yoshitaka Mori, Minori Shimura, Kazuyo Hiyoyama, Takahiro Nakasaki, Kazuhiro Nishii, Shigehisa Tamaki, Masakatsu Nishikawa, Katsumi Deguchi, Nobuyuki Minami, Hiroshi Shiku
Journal: American Journal of Hematology (1999)
Effects of ramipril on left ventricular mass and function in normotensive, high-risk patients with normal ejection fraction. A substudy of HOPE Eva M. Lonn, Roya Shaishkoleslami, Qilong Yi, Jacqueline Bosch, Alison Magi, Salim Yusuf. McMaster University, Hamilton, ON, Canada
Journal: Journal of the American College of Cardiology (2001)
Questions and Answers
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Laboratory detection of marijuana use
Authors: R. H. Schwartz
Journal: JAMA (1985)

Frequent smoking of cannabis (marijuana) has been shown to be associated with a decline in social, mental, and perceptual skills and, during adolescence, with maladaptive emotional development. Urinalysis for the detection of such use can be a useful tool for the physician responsible for treatment and counseling of adolescents who develop habitual use of marijuana. Primary methods for urinalysis detection of cannabis use include the homogenous enzyme immunoassay (EMIT) and the radioimmunoassay. These and other methods are discussed along with the issues of "false" results (both positive and negative) and the "limits of interpretation" that can be placed on a positive urine result. The pharmacokinetics and metabolism of the active constituents of cannabis are described as well as the interpretation of urinalysis results as they relate to use patterns. Guidelines are presented for the primary care physician for selecting candidates for such testing and for the use of such tests in the treatment or counseling of adolescents for whom marijuana abuse has become a psychological and social problem. (<i>JAMA</i>1985;254:788-792)
Nouveau traité de médecine.
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Book Review Your Money or Your Life: The Health Care Crisis Explained By Marc J. Roberts, with Alexandra T. Clyde. 192 pp. New York, Doubleday, 1993. $9.95. 0-385-47356-7 Code Blue: Health Care in Crisis By Edward R. Annis. 278 pp. Washington, D.C., Regnery Gateway, 1993. $21.95. 0-89526-515-X Dear America By Melvin Konner. 96 pp. Reading, Mass., Addison-Wesley, 1993. $8.95. 0-201-40631-4 The National Health Program Book By David V. Himmelstein and Steffie Woolhandler. 288 pp. Monroe, Me., …
Authors: Arnold S. Relman
Journal: New England Journal of Medicine (1994)
Interferon alfa down-regulates collagen gene transcription and suppresses experimental hepatic fibrosis in mice
Authors: Yutaka Inagaki, Tomoyuki Nemoto, Miwa Kushida, Yin Sheng, Kiyoshi Higashi, Kazuo Ikeda, Norifumi Kawada, Fumiaki Shirasaki, Kazuhiko Takehara, Kota Sugiyama, Mitsukiyo Fujii, Hiroshi Yamauchi, Atsuhito Nakao, Benoit de Crombrugghe, Tetsu Watanabe, Isao Okazaki
Journal: Hepatology (2003)

The equilibrium between the production and degradation of collagen is rigorously controlled by a number of growth factors and cytokines. Interferon alfa (IFN-α) is now widely used for the treatment of chronic hepatitis C, which can improve serum levels of fibrotic markers and the degree of hepatic fibrosis, not only in patients who responded to therapy but also in those in whom it is ineffective. These findings may suggest that IFN-α possesses direct antifibrotic effects in addition to its antiviral activity. However, in contrast to IFN-γ, which has been shown to suppress collagen gene transcription, little is known about the mechanisms responsible for the antifibrotic effects of IFN-α. Here, we report that IFN-α, when administered into transgenic mice harboring the α2(I) collagen gene (COL1A2) promoter sequence, significantly repressed promoter activation and prevented the progression of hepatic fibrosis induced by carbon tetrachloride injection. Transient transfection assays indicated that IFN-α decreased the steady-state levels of COL1A2 messenger RNA (mRNA) and inhibited basal and TGF-β/Smad3-stimulated COL1A2 transcription in activated hepatic stellate cells (HSC). These inhibitory effects of IFN-α on COL1A2 transcription were exerted through the interaction between phosphorylated Stat1 and p300. Blocking of the IFN-α signal by overexpressing the intracellular domain-deleted IFN receptor increased basal COL1A2 transcription and abolished the inhibitory effects of IFN-α. In conclusion, our results indicate that IFN-α antagonizes the TGF-β/Smad3-stimulated COL1A2 transcription in vitro and suppresses COL1A2 promoter activation in vivo, providing a molecular basis for antifibrotic effects of IFN-α. (Hepatology 2003;38:890–899).
ARTIFICIAL RIPENING OF IMMATURE CATARACTS.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
<i>Announcement:</i> Get Smart About Antibiotics Week — November 14–20, 2016
Journal: MMWR Morbidity and Mortality Weekly Report (2016)

Get Smart About Antibiotics Week is November 14-20, 2016. This annual observance is intended to engage health care providers, professional societies, advocacy groups, for-profit companies, state and local health departments, the general public, the media, and others in an effort to improve antibiotic stewardship in outpatient, inpatient, nursing home, and animal health settings. During this week, participants will raise awareness of the threat of antibiotic resistance and emphasize the importance of appropriate antibiotic use across all health care settings. Get Smart About Antibiotics Week coincides with the World Health Organization's World Antibiotic Awareness Week and European Antibiotic Awareness Day (November 18). In addition to the United States and European Union, other participating countries and international organizations include Australia, Canada, and the Pan American Health Organization.
Erratum: Patatin-like phospholipase domain-containing 3/adiponutrin deficiency in mice is not associated with fatty liver disease
Authors: Weiqin Chen, Benny Chang, Lan Li, Lawrence Chan
Journal: Hepatology (2010)

In the September 2010 issue of Hepatology (volume 52, number 3), in the article entitled "Patatin-Like Phospholipase Domain-Containing 3/Adiponutrin Deficiency in Mice Is Not Associated With Fatty Liver Disease" (pages 1134-1142) the second sentence of the financial support footnote should be changed to "W.C. was supported in part by a mentor-based postdoctoral fellowship from the American Diabetes Association (no. 7-06-MN-10) and by a postdoctoral fellowship from the American Heart Association (no. 0825134 F)."
THE LANGUAGE OF MEDICAL TERMINOLOGY AND MEDICAL CONGRESSES.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Beyond the Supreme Court ruling on alcoholism as willful misconduct: it is up to Congress to act
Authors: T. V. Seessel
Journal: JAMA (1988)

By the narrowest of margins in a complicated case, the US Supreme Court on April 20 upheld the Veterans Administration (VA) ruling that two recovering alcoholic Army veterans were not entitled to an extension of time in which to use their GI Bill education benefits. The Court explicitly did not decide whether alcoholism is a disease.<sup>1</sup> In this case, Eugene Traynor and James P. McKelvey had requested additional time beyond their ten-year entitlement for GI benefits. They were unable to complete college in the ten-year period because of their alcoholism. They were not seeking special benefits. Granting the extension would not have entailed any additional government expenditures beyond those that would have been spent within the ten-year entitlement. The VA may grant an extension in cases where a disability prevents use of the benefits in ten years, provided the disability was not the result of "willful misconduct. "<sup>2</sup>The
COUNCIL ON MEDICAL SERVICE
Journal: JAMA (1953)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The effect of starvation and repletion on plasma fibronectin in man
Authors: R. L. Scott
Journal: JAMA (1982)

Since circulating fibronectin levels have been associated with trauma, the relationship between fibronectin and fasting was investigated. Eighteen healthy but obese patients fasted for 21 days, and plasma fibronectin levels were determined weekly. Fibronectin concentrations were reduced throughout the fast, but increased after food intake. This starvation-induced decrease in fibronectin may be a deleterious mechanism associated with physiological insults. (<i>JAMA</i>1982;248:2025-2027)
Tissue transformation into bone in vivo. A potential practical application
Authors: R. K. Khouri
Journal: JAMA (1991)

The transformation of mesenchymal tissue, such as muscle, into cartilage and bone can be induced by the recently purified osteoinductive factor, osteogenin, and by its parent substratum, demineralized bone matrix. We investigated the possibility of transforming readily available muscle flaps into vascularized bone grafts of various shapes that could be used as skeletal replacement parts. In a rat experimental model, thigh adductor muscle island flaps were placed inside bivalved silicone rubber molds. Prior to closure of the mold, 18 flaps were injected with osteogenin and coated with demineralized bone matrix. Five flaps served as controls and were injected with the vehicle only, and not coated with demineralized bone matrix. The molds were implanted subcutaneously in the rats' flanks and reopened 10 days later. The control flaps consisted of intact muscle without any evidence of tissue transformation, whereas the flaps treated with osteogenin and demineralized bone matrix were entirely transformed into cancellous bone that matched the exact shape of the mold. Using tissue transformation, we were able to generate in vivo, autogenous, well-perfused bones in the shapes of femoral heads and mandibles. (<i>JAMA</i>. 1991;266:1953-1955)
Die Indicanämie: Ihre Bedeutung als Nierenfunktionsprobe.
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
HEALTH SERVICES IN MANCHESTER: WIDER POWERS RECOMMENDED FOR M.O.H.
Journal: BMJ (1935)

BuirT 2 IMEDieAL JOURtNAL, 1 this plan should be continued until the discharge has almost ceased.It is difficult to assign any definite-time period to this phase, but on an average it extends from ten to fourteen days.When the drainage tube is removed a small portion of dental rubber is placed in the wound, but it should not enter the pleural space.In a favourable case healing is complete within three to four weeks of the operation.
Annual and Analytical Cyclopedia of Practical Medicine
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Serum alkaline phosphatase isoenzymes in sickle cell anemia
Authors: J. I. Brody
Journal: JAMA (1975)

Alkaline phosphatase isoenzymes in sera from patients with sickle cell anemia were separated by electrophoresis on starch gel. Physical and biochemical criteria identified bone alkaline phosphatase as the principal, although not necessarily the sole, enzyme fraction that increases during symptomatic sickle cell crises. Moreover, there appeared to be concordance between crisis severity, serum levels of alkaline phosphatase, and isoenzyme patterns; electrophoretic and biochemical abnormalities could be detected even when the patients were asymptomatic. The present data suggest that the serum alkaline phosphatase level may be an additional indicator of the degree, frequency, and persistence of tissue injuries that occur in sickle cell anemia. (<i>JAMA</i>232:738-741, 1975)
Preventive medicine by risk factor analysis
Authors: D. G. Miller
Journal: JAMA (1972)

The operational procedures of a preventive medicine clinic have been structured so as to provide selective testing for specific diseases according to a patient's individual risk factors. Diseases included in this program met arbitrarily defined criteria regarding incidence and mortality, benefit of early diagnosis, and availability of satisfactory diagnostic procedures. For each of the diseases which met these criteria, a data reference set was prepared which defined early diagnosis and presented risk factors. Advice rules for the selection of appropriate tests, medical surveillance, and counseling were prepared as procedural logic trees for each disease. The medical record was prepared in a one-page format which lends itself to problem identification, trend analysis, and patient counseling.