tbuckley/cabot-search huggingface dataset:
THE LESIONS OF UREMIA.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Promoting the healthy development of adolescents
Authors: S. G. Millstein
Journal: JAMA (1993)

ADOLESCENCE is a period of great risks and opportunities. The dramatic biological changes that accompany this transition are essentially the same as they have been for millennia, but the social context in which they occur is very different from earlier times and continues to change rapidly. Changes in the American family, the economic structure, the media, and the community have all affected the way adolescents live and interact with peers and with the rest of society. Within this social context, adolescents need to find ways to develop a vision of the future, to formulate an image of what adulthood offers and demands, and to work out a perception of opportunity and paths toward practical implementation of such opportunity.<sup>1</sup> The profoundly transformed conditions of contemporary society present remarkable opportunities to shape behavior in ways that establish healthy life-styles that are likely to endure through the adult years, yet they also
Diphenylhydantoin in the treatment of duodenal ulcer
Authors: R. E. Buckley
Journal: JAMA (1972)

<h3>To the Editor.—</h3> In "Anthropomorphic Reductionism" the writer notes the questionable semantics of applying, to information-processing machines, terms that suggest some kind of inner "subjective" consciousness. I suppose that most of the technical men who use those terms think of them as verbal short-cuts. Yet verbal short-cuts have a nasty tendency to be extrapolated far beyond the intention of their coiners. At the same time, the semantics of the distinction—between machines and people, so to speak—is not much better worked out than that of the abuses themselves. At the present time, information-processing machines are mostly of the "programmed" type, ie, the programmer sets up a limited set of situations to which the machine reacts in a predetermined pattern; situation A, that is, always evokes response A'. But just around the corner of the future is the "self-programming computer." Here the machine is given a set of norm-priorities (observe how carefully
Antigenic relevance of F protein in chronic hepatitis C virus infection
Authors: Florence Komurian-Pradel, Alain Rajoharison, Jean-Luc Berland, Valérie Khouri, Magali Perret, Mark Van Roosmalen, Stanislas Pol, Francesco Negro, Glaucia Paranhos-Baccalà
Journal: Hepatology (2004)

The hepatitis C virus (HCV) F protein is a recently described, frameshift product of HCV core encoding sequence of genotype 1a. Its function and antigenic properties are unknown. Using enzyme-linked immunosorbent assay, we assessed the prevalence of anti-F antibodies in 154 patients chronically infected with HCV, 65 patients with other liver diseases, and 121 healthy controls. For this purpose, we expressed a highly purified HCV F recombinant protein from HCV genotype 1a in Escherichia coli. Because the F protein shares the 10 first amino acids with the core protein, the anti-HCV F response was also assessed by a F recombinant protein deleted of its 10 first amino acids [Delta(1-10)-F]. Ninety-six (62%) of the 154 HCV serum samples reacted with the complete F recombinant protein, whereas 39 (25%) showed a weaker anti-Delta(1-10)F reactivity and 150 (97%) had anti-core antibodies. No reactivity against F, Delta(1-10)F, or core was detected in any of the controls. To exclude a potential cross-reaction of anti-F antibodies with anti-core antibodies, a specific enzyme-linked immunosorbent assay was performed for anti-core antibodies. The specificity of anti-F antibodies was confirmed using an F synthetic peptide. The prevalence of anti-F antibodies did not correlate with HCV RNA serum level, genotype, or stage of liver disease. Sequence analysis from 8 anti-F-positive and 5 anti-F-negative serum samples did not reveal any particular difference potentially accounting for their respective anti-F responses. In conclusion, the F protein elicits specific antibodies in 62% of individuals chronically infected with HCV; such anti-F response does not seem to be affected by the F sequence heterogeneity.
Characterization of a Highly Negative and Labile Binding Protein Induced in Euglena gracilis by Cadmium
Authors: David J. Gingrich, Daniel N. Weber, C. Frank Shaw, Justine S. Garvey, David H. Petering
Journal: Environmental Health Perspectives (1986)

The physiochemical properties and physiological significance of the cadmium-binding protein (CdBP) of the algae Euglena gracilis have been studied.Following in vivo exposure of cells to 0.4 or 1.3 ,ug/mL of Cd2", all the cytosolic Cd is bound to high molecular weight species.At 4.7 ,ug/mL, appreciable CdBP has formed in cells grown under illumination or in the dark.An analogous ZnBP could not be isolated from control or Zn-exposed (20 ,ug/mL) cells, but zinc and a trace of copper were bound to the CdBP when 2-mercaptoethanol (2-ME) is added to the homogenates of Cd-treated cells and the buffers used during isolation.The large pool of very low molecular weight zinc species previously reported is increased when cells are exposed to high cadmium levels.Two distinct species, BP-1 and BP-2 are resolved by ion-exchange chromatography on DEAE-Sephadex.Unusually high conductivities (25 and 40 mSiemen) are required to displace them, indicating that they are very negatively charged proteins at pH 8.6.The pH for half-titration of bound Cd2' is between 5 and 6.EDTA (0.4 M) and the CdBP isolated by gel-exclusion chromatography react biphasically with pseudo-first-order rate constants of 4 ± 3 x 10-4 sec' and 7 ± 2 x 10' sec'.Neither form of the CdBP cross-reacts with antibodies to rat liver metallothionein (MT) antibodies.The structural, chemical, and functional differences between the Euglena CdBPs and mammalian MTs are discussed.When cells are exposed to high levels of Cu (5 or 10 ,ug/mL), a CuBP is induced, and the very low molecular weight zinc band is depleted.Their copper-rich cytosol has a green-black color which is lost upon oxidation.
Lumbar Sympathectomy
Authors: P. A. G. Monro
Journal: BMJ (1961)

Advances in technology have led to a massive expansion in the capacity for genomic analysis, with a commensurate fall in costs. The clinical indications for genomic testing have evolved markedly; the volume of clinical sequencing has increased dramatically; and the range of clinical professionals involved in the process has broadened. There is general acceptance that our early dichotomous paradigms of variants being pathogenic–high risk and benign–no risk are overly simplistic. There is increasing recognition that the clinical interpretation of genomic data requires significant expertise in disease–gene-variant associations specific to each disease area. Inaccurate interpretation can lead to clinical mismanagement, inconsistent information within families and misdirection of resources. It is for this reason that ‘national subspecialist multidisciplinary meetings’ (MDMs) for genomic interpretation have been articulated as key for the new NHS Genomic Medicine Service, of which Cancer Variant Interpretation Group UK (CanVIG-UK) is an early exemplar. CanVIG-UK was established in 2017 and now has &gt;100 UK members, including at least one clinical diagnostic scientist and one clinical cancer geneticist from each of the 25 regional molecular genetics laboratories of the UK and Ireland. Through CanVIG-UK, we have established national consensus around variant interpretation for cancer susceptibility genes via monthly national teleconferenced MDMs and collaborative data sharing using a secure online portal. We describe here the activities of CanVIG-UK, including exemplar outputs and feedback from the membership.
The muscular dystrophies and related disorders. II. Diseases simulating muscular dystrophies
Authors: T. Furukawa
Journal: JAMA (1978)

BETWEEN the middle and the end of the 19th century, muscular dystrophies were established as clinical and pathological entities distinct from neurogenic muscular atrophies. However, keen eyes of excellent clinicians have never overlooked unusual signs occasionally observed in muscular dystrophy patients. Landouzy and Déjèrine<sup>1</sup>observed fasciculations in one of their patients with facioscapulohumeral (FSH) dystrophy and stated, "Fibrillary contractions of muscle favor myelopathy." Some cases of atypical muscular dystrophies with fasciculations have been described. As early as 1886 Penzoldt<sup>2</sup>recognized such a disease and considered it a transitional form between muscular dystrophy and spinal muscular atrophy. Erb<sup>3</sup>in 1910 emphasized the difficulty in diagnosing muscular dystrophy because of the presence of such a transitional form. However, little attention was paid such atypical muscular dystrophies. Recently, biochemical, electron microscopic, and electrophysiological studies have shown the presence of several new diseases, some of which are clinically difficult to differentiate
Manuscripts Approved for JNCI, May 1 to June 1, 1965
Journal: JNCI Journal of the National Cancer Institute (1965)

Manuscripts Approved for JNCI, May 1 to June 1, 1965 Get access JNCI: Journal of the National Cancer Institute, Volume 35, Issue 1, July 1965, Pages 235–236, https://doi.org/10.1093/jnci/35.1.235 Published: 01 July 1965
Editorial Board
Authors: P Coates, Olivier Devuyst, Tilman Drueke, Paris Ckd, Jürgen Floege, Aachen Glomerulonephritis, Agnes Fogo, T Alp Ikizler, Jai Radhakrishnan, York Kir, Germaine Wong, Pierre Ronco, Brad Rovin, Detlef Schlöndorff, New York, Qais Al-Awqati, Saulo Klahr, St Louis, Thomas Andreoli, Little Rock, Roscoe Robinson, Durham Nephrology, Christina Wyatt, Vic Hasselblad, Jacksonville Zhezhen, Joseph Kim, Yi-Ju Li, , Durham, Dorothea Nitsch, London Ramakrishnan, Anupam Agarwal, Hans Anders, Jonathan Barratt, David Basile, Francois Berthoux, Emmanuel Loire, São Burdmann, Daniel Paulo, Christos Toronto, Yi-Pu Paris, Erik Chen, Steven Christensen, New Coca, Terence York, London Cook, D Vivette, New Agati, Farhad York, John Danesh, Andrew Daugirdas, Ian Davenport, Marc De Boer, Vikas Antwerp, St Dharnidharka, Kent Louis, Zheng Doi, Adriana Dong, Kai-Uwe Oviedo, Berlin Eckardt, Eiam-Ong Somchai, Michael Emmett, Dallas Endre, Sydney Evan, Pieter Evenepoel, Sarah Leuven, Denver Faubel, Fernando Faul, Rochester Fervenza, Danilo Mineola, Alessia Homburg, Barry Miami, Winston-Salem Freedman, Isehara Masafumi Fukagawa, Vesna Garg, Rochester Garovic, Laguna Glassock, Glenda Niguel, David Gobe, New Goldfarb, Matthew York, Mark Griffin, Angeles Haas, John Haase, Cijiang He, Michelle Hladunewich, Thomas Hostetter, Chi-Yuan Cleveland, San Hsu, Tobias Francisco, Benjamin Huber, St Humphreys, Reiko Louis, Jula Tokyo, Dallas Inrig, Francisco Kirsten Johansen, Roberto Kamyar Kalantar-Zadeh, Iowa Kalil, Yashpal City, Chicago Kanwar, New Kaskel, Krzysztof York, York Kiryluk, Clayton Kitching, Matthias Kopp, Ann Kretzler, Christian Arbor, Christophe Bonn, Paris Legendre, Los Lemley, Adeera Angeles, Philip Levin, Hong Li, Christoph Kong, John Toronto, Rochester Lieske, Jiannong Little, Kathleen Liu, San Liu, Youhua Francisco, Zhi-Hong Liu, Nanjing Liu, Dallas Lu, Matthias Berlin, Johannes Mack, Peter Mann, Hamilton Margetts, New Glen Markowitz, Ziad York, Kunihiro Paris, Rajnish Matsushita, Timothy Mehrotra, Palo Meyer, Jeffrey Alto, St Miner, William Louis, Houston Mitch, Jeremiah Moeller, St Morrissey, Rosa Louis, São Moysés, Rama Paulo, Peter Duarte, David Nelson, Clayton Nikolic-Paterson, Klaus Charlottesville, Juan Oliver, York Charles O'neill, Atlanta Panzer, Mark Perazella, New Haven, Janos Peti-Peterdi, Los Angeles, Laura Plantinga, Atlanta Pollak, Didier Boston, Ambra Charlottesville, Susan Pozzi, Chicago Quaggin, Pia Maria, Milan Rastaldi, San Reeves, Heather Antonio, Jochen Reich, Giuseppe Reiser, Sharon Bergamo, Mariano Clayton, Mitchell Rodriguez, Michael Rosner, Robert Ross, Simone Safirstein, New Sanna-Cherchi, Antonio York, Kai Santoro, New Schmidt-Ott, Stephan York, Aarau Segerer, Sharma Kumar, La Jolla, Katalin Susztak, Tetsuhiro Tanaka, Tokyo Sydney, C Tang, Hong Kong, Ravi Thadhani, Joshua Boston, Jens Denver, Marcello Singapore, Frank Tonelli, Manjeri Van Der Sande, San Venkatachalam, Carsten Antonio, Joel Wagner, Ann Weinberg, Matthew Arbor, Donald Weir, Temple Wesson, Jack Westenfelder, Adam Wetzels, Myles Whaley-Connell, Keng-Thye Durham, Kwan-Dun Woo, Taiwan Wu, Yusuke Suzuki, Tokyo Zeisberg
Journal: Kidney International (2019)
Effect of Memantine on Cue-Induced Alcohol Craving in Recovering Alcohol-Dependent Patients
Authors: Evgeny Krupitsky
Journal: American Journal of Psychiatry (2007)

Objective: Ethanol blocks N -methyl- d -aspartic acid (NMDA) glutamate receptors. Increased NMDA receptor function may contribute to motivational disturbances that contribute to alcoholism. The authors assessed whether the NMDA receptor antagonist memantine reduces cue-induced alcohol craving and produces ethanol-like subjective effects. Method: Thirty-eight alcohol-dependent inpatients participated in three daylong testing sessions in a randomized order under double-blind conditions. On each test day, subjects received 20 mg of memantine, 40 mg of memantine, or placebo, and subjective responses to treatment were assessed. The level of alcohol craving was assessed before and after exposure to an alcohol cue. Results: Memantine did not stimulate alcohol craving before exposure to an alcohol cue, and it attenuated alcohol cue-induced craving in a dose-related fashion. It produced dose-related ethanol-like effects without adverse cognitive or behavioral effects. Conclusions: These data support further exploration of whether well-tolerated NMDA receptor antagonists might have a role in the treatment of alcoholism.
ALBUMINURIA AND NEPHRITIS IN THE COURSE OF DISEASES OF THE SKIN.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
RECURRENT HYPERPARATHYROIDISM
Authors: GUNTER LAUBINGER, M.D., J. MARTIN MILLER, M.D., RICHMOND W. SMITH, M.D.
Journal: Annals of Internal Medicine (1960)

ExcerptPrimary hyperparathyroidism has held the curiosity of many physicians and clinical investigators since Mandl in 1925 performed the first operation for this condition. Our interest was recently attracted by a patient with recurrent hyperparathyroidism, a problem Mandl1had actually encountered in his original patient. Although several other cases have been mentioned in the many reports of patients with hyperparathyroidism, only a few authors have been primarily concerned with its clinical significance. Hellstrom2discussed recurrence in his recent report of 92 patients with hyperparathyroidism. In 20 of these, the first operation was unsuccessful. Janelli,3on the other hand, did not mention...
Plastic and Reconstructive Surgery, Baltimore
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mycobacterium marinum infection. A fishy story
Authors: J. P. Bailey
Journal: JAMA (1982)

INFECTION of articular and paraarticular tissue by<i>Mycobacterium marinum</i>is reported infrequently. In a recent review of atypical mycobacterial joint infections,<sup>1</sup>only one was diagnosed and treated without surgery. Even in that case, drug therapy (aminosalicylic acid, isoniazid, and streptomycin sulfate) was considered "empirical" and probably not related to healing.<sup>2</sup>In our case, the diagnosis was made without surgical biopsy, and excellent response was obtained through drug therapy alone. <h3>Report of a Case</h3> A 55-year-old man, previously in good health, sustained a puncture wound over the palmar surface of the second digit of the right hand at the site of the metacarpophalangeal (MCP) joint from a fish fin (red snapper, saltwater fish, nonfrozen). The wound occurred during his work in a meat market and subsequently healed. One week after injury, swelling, erythema, and increased temperature developed on the dorsal surface of the second right MCP joint. Within another
Cherchez l'Homme?
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SOME SOURCES OF ERROR IN SKIAGRAPHS.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hospital, Rio de Janeiro
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal