tbuckley/cabot-search huggingface dataset:
Editorial: Does Crohn's disease predispose to intestinal cancer?
Journal: BMJ (1973)

3female, but in male patients these clinical clues could have some diagnostic value.But ultimate diagnosis must depend on full investigation with electromyography, serum enzyme studies, and muscle biopsy.The distinction is important, because Duchenne mus- cular dystrophy is invariably a progressive and fatal disorder.In some patients with spinal muscular atrophy the disease may undergo temporary or even prolonged arrest, and often the prognosis is 'better than it is in cases of the Duchenne type.Furthermore, an accurate diagnosis is needed for genetic counselling, as the sisters of 'boys suffering from Duchenne dystrophy may possibly be carriers of the Xlinked gene, whereas unaffected sibs of a child with spinal muscular atrophy of autosomal recessive inheritance are un- likely to pass on the disease to their offspring unless they marry a blood relation.
Colonic mucormycosis
Authors: S. Rodrigues, L. Santos, J. Nuak, J. Pardal, J. Sarmento, G. Macedo
Journal: Endoscopy (2013)

A 48-year-old man with Reiter's disease who had recently been treated with prednisolone (40 mg orally) and sulfasalazine (500 mg three times per day orally) was admitted to our hospital with abdominal pain, vomiting, and persistent fever. Empirical antibiotics were started but he developed septic shock soon after admission and was transferred to the infectious diseases intensive care unit. A computed tomography (CT) scan of his abdomen and pelvis showed thickening of the wall of the descending and transverse colon.
Hepatitis associated with ranitidine
Authors: J. D. Proctor
Journal: JAMA (1984)

<h3>To the Editor.—</h3> Hepatitis possibly caused by ranitidine has been reported but is seemingly rare.<sup>1</sup>Hepatic toxicity is also infrequently associated with cimetidine, another H<sub>2</sub>-receptor antagonist.<sup>2</sup>I wish to report apparent hepatitis in a patient after two weeks of treatment with ranitidine for esophageal reflux. <h3>Report of a Case.—</h3> A 50-year-old woman was seen with a two-year history of retrosternal burning pain, bloating, and regurgitation of food not relieved by antacid and elevation of the head of her bed. Two months prior to this visit a course of cimetidine had provided symptomatic benefit. A small hiatal hernia was now demonstrated on upper gastrointestinal tract series. Ranitidine, 150 mg, was given because the patient expressed a preference for twice-a-day dosing afforded by this drug. Fifteen days later she experienced an illness characterized by marked malaise, weakness, nausea, vomiting, headache, and steady pain in the right upper portion
StatBite Age-Specific Mammography Screening Results
Journal: JNCI Journal of the National Cancer Institute (2012)

While mammographic screening is considered the gold standard of detecting breast cancer, it can also miss cancers, resulting in "false negatives," and also reveal abnormalities that do not turn out to be cancer, or false positives.The number of false positives tends to decrease with age.These data reflect the outcomes of mammography screening results as per 1000 women in the U.S. based on Breast Cancer Surveillance Consortium Data as of 2009.
Lamentation
Authors: David L. Schiedermayer
Journal: JAMA (1986)

There will never be another day like that day, since, in the strange words of the gunfight, no one would hold his fire. There will be no preparing for that day and no surviving that day. It will be a day like no other day, when cities disappear after blast, shock, and fire, when the whole world will be ending, yet there will be no ending it; everything will be made nothing, yet still the fire will burn. The sky will be filled with the smoke of the fire, and it will reach from one horizon to another, until all is flat and empty. All who are left will be made to pass through the fire. It will be like this: there will be the burned, those whose skin is flayed. There will be those bleeding into their skin, and bleeding from their bowels; those with high fever. There will
Diagnosis of diabetic eye disease
Authors: E. J. Sussman
Journal: JAMA (1982)

The correct diagnosis of proliferative diabetic retinopathy is essential, because it is a treatable disease and missing the diagnosis can lead to the patient becoming blind. We examined the ability of internists and ophthalmologists to diagnose proliferative retinopathy under optimal conditions. Twenty-three physicians performed retinal examinations on ten diabetic patients and one normal patient with dilated pupils. Physician examiners were members of a university medical center and included 10 internists, 2 diabetologists, 4 senior medical residents, 4 general ophthalmologists, and 3 ophthalmologists who were subspecialists in retinal disease. Correct diagnosis was determined separately by the consensus of three ophthalmologists specializing in retinal disease, who reviewed seven-view stereo fundus photographs and medical charts. Of a possible 483 individual eye examinations, 438 were completed. The overall error rate was 61%. The error rate for missing the diagnosis of proliferative retinopathy varied from 0% for retinal specialists to 49% for internists, diabetologists, and medical residents. We conclude that potentially serious mistakes in diagnosis are currently made by the physicians who care for most diabetic patients. Experience and specialized knowledge lessen the error rate. Further education or greater use of referrals may be necessary to provide optimal patient care. (<i>JAMA</i>1982;247:3231-3234).
Preventive Medicine: A New Biomedical Journal
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nephrogenous Ascites
Authors: Hugh H. Hussey
Journal: JAMA (1974)

End-stage renal failure with uremia is sometimes attended by bizarre accumulations of fluid, the pathogenesis of which is not altogether clear. Examples include pulmonary edema in which the fluid is located at the hilar regions, giving a roentgenographic picture characterized as "bat wing" or "butterfly wing," and pericarditis with effusion. At times, the pericardial effusion is so extreme as to cause cardiac tamponade, requiring emergency treatment by paracentesis or pericardiectomy. A recent issue of<i>Archives of Internal Medicine</i>contains two communications that recount extraordinarily large and persistent accumulations of ascitic fluid in uremic patients. During a two-year period, Craig et al<sup>1</sup>observed six patients with chronic renal failure and persistent ascites resistant to hemodialysis in five instances. (The sixth case must be discounted since the patient refused treatment and was lost to follow-up.) All six patients underwent peritoneoscopy that failed to disclose any factor other than the uremia to
A Manual of Bacteriology.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Overview of results of randomized clinical trials in heart disease. II. Unstable angina, heart failure, primary prevention with aspirin, and risk factor modification
Authors: S. Yusuf
Journal: JAMA (1988)

THIS is the second of a two-part article on the results of randomized trials of treatments designed to reduce mortality or major morbidity in heart disease. Our goal is to summarize the results of trials of common treatments on major outcomes in unstable angina, congestive heart failure, primary prevention with aspirin, and risk factor modification. This summary should provide useful background information against which clinicians must consider other information (eg, patient prognosis, risk of side effects, drug interactions, and specific clinical picture) in making decisions about individual patients. We do not deal in either article with trials of coronary artery bypass graft surgery for stable angina, trials of valve replacement, or congenital heart disease. The risk reductions are based on the odds ratio calculated by the Mantel-Haenszel method as applied to combining data from several trials. When event rates are low, the odds ratio and the relative risk are numerically
GRK6 Regulates the Hemostatic Response to Injury through Its Rate-Limiting Effects on GPCR Signaling in Platelets
Authors: Xi Chen, Shuchi Gupta, Matthew Cooper, Daniel Dehelian, Xuefei Zhao, Lawrence F. Brass, Ulhas P. Naik, Meghna Ulhas Naik, Jeffrey Benovic, Peisong Ma
Journal: Blood (2019)
Massachusetts Medical Society
Authors: John Figgis Jewett
Journal: New England Journal of Medicine (1959)

Huge Retroperitoneal Liposarcoma Invading Kidney and Displacing VisceraA thirty-one-year-old gravida 3, para 2, died two weeks after a spontaneous stillbirth at thirty-two weeks. Both previous pregnancies, at nineteen and twenty-two years of age, had been uneventful.At the age of twenty-six, after extensive studies for severe digestive symptoms, a diagnosis of acute cholecystitis and pyelitis was made. Hepatitis and other liver ailments were ruled out. The patient was treated with cortisone and was discharged on the fourteenth hospital day much improved.During the current pregnancy, after five years with no symptoms at all, she was admitted to the hospital . . .
Increased CD36 protein as a response to defective insulin signaling in macrophages
Authors: Chien-Ping Liang, Seongah Han, Haruka Okamoto, Ronald Carnemolla, Ira Tabas, Domenico Accili, Alan R. Tall
Journal: Journal of Clinical Investigation (2004)

Accelerated atherosclerosis is a major cause of morbidity and death in insulin-resistant states such as obesity and the metabolic syndrome, but the underlying mechanisms are poorly understood. We show that macrophages from obese (ob/ob) mice have increased binding and uptake of oxidized LDL, in part due to a post-transcriptional increase in CD36 protein. Macrophages from ob/ob mice are also insulin resistant, as shown by reduced expression and signaling of insulin receptors. Three lines of evidence indicate that the increase in CD36 is caused by defective insulin signaling: (a) Treatment of wild-type macrophages with LY294002, an inhibitor of insulin signaling via PI3K, results in an increase in CD36; (b) insulin receptor knockout macrophages show a post-transcriptional increase in CD36 protein; and (c) administration of thiazolidinediones to intact ob/ob mice and ob/ob, LDL receptor–deficient mice results in a reversal of macrophage insulin receptor defects and decreases CD36 protein. The last finding contrasts with the increase in CD36 that results from treatment of macrophages with these drugs ex vivo. The results suggest that defective macrophage insulin signaling predisposes to foam cell formation and atherosclerosis in insulin-resistant states and that this is reversed in vivo by treatment with PPAR-γ activators.
Radiation-Induced Cell Transformation: Transformation Efficiencies of Different Types of Ionizing Radiation and Molecular Changes in Radiation Transformants and Tumor Cell Lines
Authors: L. Hieber, K. Trutschler, J. Smida, M. Wachsmann, G. Ponsel, A. M. Kellerer
Journal: Environmental Health Perspectives (1990)

This study aims to compare the efficiencies of 5.4 keV soft X-rays, alpha-particles, and gamma-rays in transforming C3H 10T1/2 cells and to assess the sequence of cellular and molecular changes during the process of radiation-induced transformation of Syrian hamster embryo (SHE) cells. The somewhat more densely ionizing soft X-rays are more effective than gamma-rays both for cell inactivation and cell transformation. The relative biological effectiveness (RBE) appears to be independent of dose; it is approximately 1.3 for either end point. The RBE of alpha-particles versus gamma-rays, on the other hand, increases with decreasing dose; the dose dependence is somewhat more apparent for cell transformation than for cell inactivation. SHE cells transformed by different types of ionizing radiation and related tumor cell lines isolated from nude mice tumors were found to have a distinct growth advantage compared to primary SHE cells, documented by higher plating efficiencies, shorter doubling times, and higher cloning efficiencies in semisolid medium. Most transformed and tumor cell lines that were investigated have elevated mRNA levels for the H-ras gene, some of them show restriction fragment length polymorphisms of the H-ras gene, and some exhibit a substantially amplified c-myc gene. In a sequence analysis of the Syrian hamster H-ras gene of eight tumor cell lines from radiation transformants, we have not found any mutation in codons 12, 13, 59, 61, nor in the flanking regions of these codons. The transformed and tumor cell lines tend to have lower chromosome numbers than primary SHE cells.
Public Health and Safety Concerns of the AMA-RPS
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Animal Feed Antibiotic Use Raises Drug Resistance Fear
Authors: C. Marwick
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract P040: Home Proximity to Flower Plantations and Higher Systolic Blood Pressure
Authors: Jose R Suarez-Lopez, David R Jacobs, John H Himes, Bruce Alexander
Journal: Circulation (2012)

People residing near agricultural plantations have greater risk of pesticide exposure, primarily due to pesticide drift after fumigation. Overall pesticide exposure and pyrethroid pesticides have been associated with increased blood pressure. We previously found that decreases in acetylcholinesterase activity (reflecting organophosphate pesticide exposure) were associated with home proximity to flower plantations. We also found that lower acetylcholinesterase activity was associated with lower blood pressure, which is plausible because higher acetylcholine concentration can decrease blood pressure by vasodilation via muscarinic receptor stimulation; likely a different mechanism of blood pressure alteration than those seen by other pesticides). We here evaluated the hypothesis that proximity of homes to fresh-cut flower plantations increases blood pressure independently of acetylcholinesterase activity among boys and girls living in a rural county in Ecuador with one of the highest concentrations of flower plantations in the country. METHODS: Geographic coordinates of homes and flower plantations were collected using global positioning system receivers. Physical examinations and parental home surveys were performed on 288 children aged 4-9 years in the study of Secondary Exposure to Pesticides among Infants, Children and Adolescents (ESPINA). RESULTS: The mean home distance to the nearest flower plantation edge was 450m (SD=352) and the median plantation area within a 150m radius from each house was 1049m2 (25th-95Th percentile=492-3172) among those with non-zero values. The mean SBP was 93.2 mmHg (SD=8.3). Proximity of homes to the nearest flower plantation edge was associated with a systolic blood pressure (SBP) increase of 2.45 mmHg per 1000m (95% CI: 5.02-0.00) after adjusting for age, gender, race, heart rate, height-for-age, income, maternal education, flower worker cohabitation, and examination date. Addition of erythrocytic acetylcholinesterase activity and hemoglobin concentration strengthened the association (3.02 mmHg per kilometer, 95% CI: 5.64-0.09). Increasing flower plantation area within a 150 meter radius from each home was associated with SBP increases of 3.25 per 10,000m2. Addition of acetylcholinesterase activity and hemoglobin strengthened this association (3.41mmHg per 10,000m2, 95% CI: 0.23-6.59). CONCLUSIONS: Proximity of homes to flower plantations and greater extensions of flower plantations within a 150m radius from the home were associated with systolic blood pressure increases independent of organophosphate pesticide (cholinergic) pathways. This supports the hypothesis that pesticide drifts from agricultural plantations may be sufficient to effect physiologic changes on children living in agricultural communities.
Reply†
Authors: Thierry Gustot, Richard Moreau
Journal: Hepatology (2010)

We appreciate the comments of Berry et al. who emphasize the fact that our review article focused on the early phase of sepsis (i.e., "cytokine storm") and did not pay sufficient attention to the second phase of sepsis (i.e., "immune paralysis", which may be lethal). 1 It should be noted that there is a substantial amount of data regarding the early phase of sepsis in patients or animals with cirrhosis. Many patients with cirrhosis admitted for severe sepsis die within the first hours. 2, 3 At the onset of bacterial infection, circulating levels of proinflammatory cytokines tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) are higher in patients with cirrhosis than in patients who do not have cirrhosis. 4 Experiments performed in immune cells from noninfected patients with cirrhosis show a defect in the production of anti-inflammatory IL-10 during the first hours of ex vivo exposure to lipopolysaccharide. 5 Among patients with cirrhosis and spontaneous bacterial peritonitis, renal failure develops in those who have the highest levels of TNF-α and IL-6 in the blood and ascites. 6 Hyperproduction of TNF-α plays a major role in the development of liver injury in a model of lipopolysaccharide-induced sepsis in cirrhotic rats. 7 On the other hand, the second phase of sepsis-induced "immune paralysis" is less documented in patients with cirrhosis. Available data are often preliminary and all were obtained in patients with cirrhosis and acute-on-chronic liver failure due to different causes (gastrointestinal bleeding, infections). 8-10 In other words, studies are needed to specifically investigate "immune paralysis" in patients with cirrhosis and sepsis. We agree with Berry et al. that this may lead to new therapeutic strategies aimed at improving the prognosis in those patients with cirrhosis admitted for sepsis who reach the second phase of "immune paralysis". Thierry Gustot M.D., Ph.D.* , Richard Moreau M.D.* , * INSERM U773, Centre de Recherche Biomédicale Bichat-Beaujon CRB3, Clichy/Paris, France, Liver Unit, Beaujon Hospital, Clichy, and Université Denis Diderot–Paris VII, Paris, France, Department of Gastroenterology, Erasme Hospital Université Libre de Bruxelles, Brussels, Belgium