tbuckley/cabot-search huggingface dataset:
`Senile' Osteoporosis Reconsidered
Authors: Neil M. Resnick
Journal: JAMA (1989)

Osteoporosis is a devastating, morbid, and costly condition whose ravages are felt most profoundly by women over age 70 years. Yet most research on its prevention and treatment has focused on perimenopausal women, although there are significant differences between perimenopausal and older women in factors related to bone mineral metabolism, rates of bone loss, the structural integrity of remaining bone, risk factors for fractures, and the types of fractures sustained. Currently recommended therapies, which slow bone loss in perimenopausal women, may be of less benefit for older women whose loss of bone has already slowed or ceased and whose remaining bone may be of inadequate quantity and quality to prevent fracture. Thus, the application of currently available modalities is unlikely to mitigate significantly the consequences of osteoporosis in this population. Further research is urgently needed, and some directions for future investigation are suggested. (<i>JAMA</i>1989;261:1025-1029)
Update: Leptospirosis and Unexplained Acute Febrile Illness Among Athletes Participating in Triathlons--Illinois and Wisconsin, 1998
Journal: JAMA (1998)

Since July 14, 1998, the Illinois Department of Health, the Wisconsin Department of Health, the U.S. Department of Agriculture (USDA), and CDC, in collaboration with other state and local health departments, have been investigating an outbreak of acute febrile illness among athletes from 44 states and seven countries who participated in triathlons in Springfield, Illinois, on June 21, 1998, and in Madison, Wisconsin, on July 5, 1998. Initial testing at CDC of specimens from four athletes identified leptospirosis as the illness in all four. This report updates the ongoing investigation of this outbreak through August 13, which indicates that Leptospira was the etiologic agent for illness in athletes and in persons with occupational or recreational exposure to Lake Springfield, where the event was held in Illinois.
Yersinia enterocolitica Enteritis in Children
Authors: William J. Rodriguez
Journal: JAMA (1979)

Five patients were admitted to Children's Hospital National Medical Center with manifestations of<i>Yersinia enterocolitica</i>infections. Four of five had primarily enteric illness, while the fifth had associated ocular and joint involvements. In three of five cases, the disease was self-limiting. Two of the patients (No. 1 and 2) may have had their disease improved by antibiotic therapy. Increased alertness to the potential of<i>Y enterocolitica</i>to cause a variety of syndromes is necessary to make an accurate bacteriologic diagnosis and to expedite medical treatment. (<i>JAMA</i>242:1978-1980, 1979)
Management of congestive heart failure in patients with acute myocardial infarction
Authors: R. Genton
Journal: JAMA (1986)

SEVERE left ventricular dysfunction induced by extensive infarction is the most common cause of in-hospital death in patients with myocardial infarction.<sup>1</sup>Prompt recognition of the clinical manifestations of congestive heart failure and an aggressive approach to therapy that improves hemodynamic performance but does not exacerbate ischemia is essential. The rationale for the aggressive management of heart failure in patients with acute infarction is based on the concept that infarction evolves over several hours and factors underlying its complications (eg, expansion, recurrent infarction, and myocardial rupture) over several days. Both the extent and complications of infarction are caused by, and are, determinants of hemodynamic factors influencing the balance between myocardial oxygen consumption and oxygen delivery. Therefore, prompt therapy is thought to reduce the extent of infarction, the probability of recurrent injury, and the propensity to expansion and cardiac rupture. Beneficial effects of treatment may lead to improved left ventricular performance
Self management of oral coagulation: randomised trial
Journal: BMJ (2005)

encouraged to exercise choice and consumer power by moving between these integrated care organisations, rather than through their choice of secondary or tertiary care providers.To prevent superpractices creaming off low risk, low cost patients, the NHS would need to develop a more sophisticated risk adjusted resource allocation formula.This could use the data now routinely collected at practice level by the new quality outcomes framework-for example, smoking status, body mass index, and blood pressure.National bodies will still be required to assess performance and conduct other monitoring, and both national and regional bodies would provide the technical and infrastructure support for assessing needs and setting priorities.Methods and criteria for managing scarcity and improving services could also be developed at this level but adapted locally with community and partnership agencies.
A statement on the generalist physician from the American Boards of Family Practice and Internal Medicine
Authors: H. R. Kimball
Journal: JAMA (1994)

PROFOUND change is under way in the health care delivery system for Americans. As our health care system moves to center on the generalist as the primary provider of health services, the acknowledged deficiency in the number of such physicians has emerged as a fundamental concern. The Clinton Health Security Act, the Council on Graduate Medical Education, the Physician Payment Review Commission, and others have called for a near doubling of the output of generalists by the end of the decade. Family physicians and general internists provide the vast majority of adult generalist care and must continue to do so to ensure the highest quality of care for the American public. The American Board of Family Practice (ABFP) and the American Board of Internal Medicine (ABIM) accept their respective roles in meeting this challenge and to this end believe there are many areas in which the two disciplines can more
The Pathology of Tumours.
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Index of Authors&lt;subtitle&gt;Volume 27 July 1961 • December 1961&lt;/subtitle&gt;
Journal: JNCI Journal of the National Cancer Institute (1961)

Journal Article Index of Authors: Volume 27 July 1961 • December 1961 Get access JNCI: Journal of the National Cancer Institute, Volume 27, Issue 6, December 1961, Pages 1517–1519, https://doi.org/10.1093/jnci/27.6.1517 Published: 01 December 1961
A Proton MRSI Study of Brain <i>N</i> -Acetylaspartate Level After 12 Weeks of Citalopram Treatment in Drug-Naive Patients With Obsessive-Compulsive Disorder
Authors: Joon Hwan Jang, Jun Soo Kwon, Dong Pyo Jang, Won-Jin Moon, Jong-Min Lee, Tae Hyun Ha, Eun Chul Chung, In Young Kim, Sun I Kim
Journal: American Journal of Psychiatry (2006)

Objective: Reductions in the level of N -acetylaspartate within subcortical structures of patients with obsessive-compulsive disorder (OCD) have been reported in several studies. However, there have been, as yet, no reports regarding N -acetylaspartate levels in the prefrontal cortex of adult drug-naive OCD patients. The authors used proton magnetic resonance spectroscopic imaging ( 1 H-MRSI) to investigate regional N -acetylaspartate level abnormalities and changes after 12 weeks of pharmacotherapy with citalopram in drug-naive OCD patients. Method: Thirteen drug-naive OCD patients and 13 age- and sex-matched healthy comparison subjects were included in this study. N -acetylaspartate levels (obtained from ratios of N -acetylaspartate with creatine, choline, and creatine plus choline) in the prefrontal cortex, parietal cortex, anterior cingulate, posterior cingulate, frontal white matter, and parietal white matter were measured by 1 H-MRSI. In OCD patients, measurements were taken before and after 12 weeks of citalopram treatment. Correlations between N -acetylaspartate concentrations in regions of interest and clinical measures were also assessed. Results: Drug-naive OCD patients exhibited significantly lower N -acetylaspartate levels in the prefrontal cortex, frontal white matter, and anterior cingulate at baseline than did comparison subjects. Significant increases in N -acetylaspartate level were detected in the prefrontal cortex and frontal white matter in OCD patients after 12 weeks of citalopram treatment. Conclusions: These data suggest that reductions in neuronal viability occur in the frontal region of OCD patients and that these reductions may be partly reversible.
Roles of Academic and Public Health Systems in Advancing Population Health—Reply
Authors: L. Ebony Boulware, Molly J. Coye, A. Eugene Washington
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Number needed to treat: enigmatic results for exacerbations in COPD
Authors: Samy Suissa
Journal: European Respiratory Journal (2015)

S. Lettis and O. Keene raise questions about my paper on some misleading uses of the number needed to treat (NNT) for study outcomes such as chronic obstructive pulmonary disease (COPD) exacerbations. Certainly, when dealing with recurrent events such as exacerbations, it is statistically more informative to analyse all events with tools such as incidence rates, rate ratios and rate differences. However, some critical assumptions about the rates are essential to obtain valid estimates of these measures and, consequently, a valid estimate of the NNT. "Event-based" numbers needed to treat, such as those from the TORCH trial, should be used with extreme caution <http://ow.ly/U31OH>
Book Review Physiology of Micturition: Experimental and clinical studies with suggestions as to diagnosis and treatment . By Orthello R. Langworthy, M.D., Lawrence C. Kolb, M.D., and Lloyd G. Lewis, M.D. 8°, cloth, 232 pp., with 49 illustrations. Baltimore: Williams and Wilkins Company, 1940. $3.50.
Journal: New England Journal of Medicine (1941)
Medical responsibility for the prolongation of life
Authors: F. D. Moore
Journal: JAMA (1968)

It is certainly appropriate to discuss transplantation in this seminar, not only because it may prolong the life of somebody who is crtitically ill but also because it requires a specific decision in many cases as to precisely when death has occurred; or, speaking in modern terms, when it is no longer to the good of society or the individual to prolong outward semblances of life in a body that lives while the brain is dead. <h3>I</h3> The various aspects bearing on the ethics of transplantation are to be analyzed under two headings: the ethics of the trial of new operations, and the ethical considerations involved with the donor. Although neither is in any sense new, the interpretation of cardiac transplantation in the light of these two problems has brought a new set of ideas and perplexities to the general public. A surprising number of eminent people, who appear to
A Phase I/II Trial of the Histone Deacetylase (HDAC) Inhibitor, Panobinostat, in Combination with Lenalidomide in Patients with Relapsed/Refractory Hodgkin’s Lymphoma (HL)
Authors: Beth Christian, Lai Wei, Jennifer Sexton, Samantha M. Jaglowski, Steven M. Devine, Todd A. Fehniger, Nina Wagner-Johnston, Nancy L. Bartlett, Kristie A. Blum
Journal: Blood (2014)
T cell anergy is reversed by active Ras and is regulated by diacylglycerol kinase-α
Authors: Yuanyuan Zha, Reinhard Marks, Allen W Ho, Amy C Peterson, Sujit Janardhan, Ian Brown, Kesavannair Praveen, Stacey Stang, James C Stone, Thomas F Gajewski
Journal: Nature Immunology (2006)
Long-term antiarrhythmic therapy in survivors of prehospital cardiac arrest. Initial 18 months' experience
Authors: R. J. Myerburg
Journal: JAMA (1977)

Ambulatory rhythm monitoring and chronic arrhythmia management were studied in 16 patients resuscitated from prehospital cardiac arrest. Asymptomatic complex ventricular arrhythmias (ACVA) occurred in 12 patients (75%) entering long-term follow-up during the first 12 months (average follow-up, 13.25 months). The patients' therapy consisted of a dose-adjusted, membrane-active antiarrhythmic drug regimen monitored by blood levels. While there has been little change in the frequency of ACVAs despite carefully controlled antiarrhythmic management, only one death has occurred during 212 patient-months of postarrest follow-up, a 6% one-year mortality. This compares favorably to our previous experience in survivors of prehospital cardiac arrest not receiving a controlled antiarrhythmic program. Despite the failure to suppress ACVAs, the drug-monitored population is showing a trend toward a decreased frequency of recurrent cardiac arrest. (<i>JAMA</i>238:2621-2624, 1977)
Immunogenicity of 1967 polyvalent and 1968 Hong Kong influenza vaccines
Authors: W. J. Mogabgab
Journal: JAMA (1970)

Influenza A2 vaccine containing 300 chick-cell agglutination (CCA) units per dose of the Hong Kong variant provided a high degree of protection during an outbreak of respiratory illnesses in military personnel in December 1968 and January 1969. This inactivated chicken embryo-propagated virus vaccine stimulated hemagglutination-inhibition antibody responses that were equivalent to natural infection. Polyvalent vaccine, 1967 formula, was not without some contribution in preventing disease in those who did not receive Hong Kong influenza vaccine. Influenza A2 comprised 56% of all respiratory illnesses during the outbreak. Virus was isolated in rhesus monkey kidney cultures from pharyngeal washings of a third of the individuals with serologic evidence of infection by influenza A2.
ETHYLENE
Authors: ARNO B. LUCKHARDT
Journal: JAMA (1924)

The fact that ethylene was introduced as an anesthetic agent only some fifteen months ago, and received prompt and favorable consideration by the medical profession soon after, would seem to indicate that its advantages over the available general anesthetics are real. Not only have favorable reports with illustrative case histories been published in this country, but in the French medical literature a similar satisfaction is expressed with its properties as an anesthetic agent. It has been introduced recently and accepted enthusiastically in the surgical clinics of the Peking Union Medical College, Peking, China. The favorable consideration that it has received was due in part to the laboratory work (on animals and man) that preceded and suggested its practical use. Had it not been, however, for the progressive scientific attitude of Drs. Dean Lewis and Arthur Dean Bevan and their anesthetists, Drs. Isabella Herb and Mary Lyons, who, following a demonstration,
Disease gravity and urgency of need as guidelines for liver allocation*1
Authors: B EGHTESAD
Journal: Hepatology (1994)

One thousand one hundred and twenty-eight candidates for liver transplantation were stratified into five urgency-of-need categories by the United Network for Organ Sharing (UNOS) criteria.Most patients of low-risk UNOS 1 status remained alive after 1 yr without transplantation; the mortality while waiting was 3% after a median of 229.5 days.In contrast, only 3% of those entered at the highest risk UNOS 5 category survived without transplantation; 28% died while waiting, the deaths occurring at a median of 5.5 days.The UNOS categories in between showed the expected gradations, in which at each higher level fewer patients remained as candidates throughout the 1-yr duration of study while progressively more died at earlier and earlier times while waiting for an organ.In a separate study of posttransplantation survival during the same time period, the best postoperative results were in the lowest-risk UNOS 1 and 2 patients (88% combined), and the worst results were those in UNOS 5 (71%).However, a relative risk cross-analysis showed that a negative benefit of transplantation may have been the result in terms of 1-yr survival for the low-risk elective patients, but that a gain in life extension was achieved in the potentially lethal UNOS categories 3, 4 and 5 (greatest for UNOS 3).These findings and conclusions are discussed in terms of total care of patients with liver disease, and in the context of organ allocation policies of the United States and Europe.Many of the earlier presentations at this Consensus Development Conference have focused on specific diseases and the wisdom of performing liver replacement for disorders that are apt to recur (such as cancer, hepatitis and alcoholic cirrhosis).Others have discussed limiting the operation to prime-of-life candidates, with exclusion of the very young or aged.Expansion of the donor pool has been proposed in the "splitting" of livers that are shared between two candidates or in the use of liver fragments from living donors.These subjects have been judiciously addressed in the context of organ shortage and allocation, leaving the all-important questions of patient disease severity and complexity almost untouched.To focus on this problem, Bronsther et al. ( 1) have analyzed elsewhere and we present here in more detail the dynamics in a collection of more than a thousand adult patients who were given candidacy in our program.The results may be useful in policy determination about organ allocation and in definition of the role of liver transplantation in the total armamentarium available to treat hepatic diseases.
Letter: Menstrual extraction
Authors: Geoffrey Davis
Journal: JAMA (1974)

<h3>To the Editor.—</h3> The COMMENTARY on menstrual extraction (228:849, 1974) is gravely in error in fact, opinion, and judgment on virtually every count. The authors appear to speak for what now could be termed "institutionalized abortion" and appear to feel threatened. It is a travesty of current medical philosophy that anyone<i>could</i>attempt to argue positive virtues for abortion in face of innovative, simpler means to rational fertility control. The new terms appeared in response to the clear need for nomenclature to distinguish the idea "menses induction as early as possible as fertility control" from both abortion and contraception. Some terminological confusion appeared from press accounts in mid 1972. It is intriguing to see the confusion perpetuated in mainstream medicine two years later. Menstrual<i>extraction</i>is vacuum curettage, usually self-employed, at or about due date of onset to avert<i>menstruation;</i>in this use fertility control is a spin-off benefit. The term
What therapy for uveal melanomas?
Journal: JAMA (1980)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hepatoblastoma in families with polyposis coli
Authors: F. P. Li
Journal: JAMA (1987)

We observed hepatoblastoma in four unrelated children who have a family history of polyposis coli and found this association in ten other kindreds in the literature. The one child in our series who has survived hepatoblastoma showed multiple colonic adenomas at 7 years of age. She and eight affected maternal relatives also had congenital hypertrophy of the retinal pigment epithelium, a new marker of gene carriers in some polyposis coli families. These findings suggest that childhood hepatoblastoma is an associated feature of familial polyposis coli. (<i>JAMA</i>1987;257:2475-2477)
Case upheld for four layer bandaging for leg ulcers
Journal: BMJ (1998)

Some small for gestational age fetuses have higher risk of late fetal death than othersIn small for gestational age fetuses, without congenital malformations, constitutionally small fetuses-for example twins or the fetuses of short mothers-have been assumed to at lower risk of late fetal death than fetuses affected by conditions such as pre-eclampsia or cigarette consumption.Cnattingius et al (p 1483) tested that assumption in over 1 million births in the Swedish birth register.Overall, late fetal mortality was increased in women who were over 35, nulliparous, smoked, or were <155 cm tall and greatly increased in those with pre-eclampsia, essential hypertension, and twin pregnancies.But in very small for gestational age fetuses death rates were lower in women aged under 35, <155 cm tall, with twins, or with severe eclampsia or hypertension.
Primary intraluminal aortic myxoma with involvement of several vertebrae
Authors: O. C. Kimbrell
Journal: JAMA (1973)

To our knowledge, only five of the reported cases of primary aortic neoplasms have been primary intraluminal myxomas. The most frequent clinical manifestations have been an accelerating, often severe, hypertension, arterial occlusive findings, and a loud aortic bruit. In this case, several vertebral bodies were invaded by the tumor.