tbuckley/cabot-search huggingface dataset:
Hemoglobin, Serum Iron, and Zinc Protoporphyrin in Lead-Exposed Workers
Authors: Ruth Lilis, J. Eisinger, W. Blumberg, A. Fischbein, I. J. Selikoff
Journal: Environmental Health Perspectives (1978)

In a previous study of secondary lead smelter workers (males), a significant prevalence of low hemoglobin levels (less than 14 g/100 ml) was found; a statistically significant negative correlation between hemoglobin and zinc protoporphyrin was also detected. In the present study serum iron (Fe) levels and total iron binding capacity (TIBC) were included in the investigation of 111 secondary lead smelter workers and 37 nonexposed controls. The distribution and mean values of serum iron and TIBC were found to be in the normal range in the lead exposed workers; there was no significant difference when compared to the control population. There was no significant correlation between blood lead or zinc protoporphyrin and serum iron, TIBC and Fe/TIBC. A statistically significant negative correlation between hemoglobin and blood lead levels was found; the correlation between hemoglobin and zinc protoporphyrin reached a much higher level of significance. The results support the view that anemia (low hemoglobin levels) in lead exposed male workers is related to the heme synthesis inhibiting effects of lead, as reflected by elevated zinc protoporphyrin levels, and is not due to iron deficiency.
PANCREATIC LITHIASIS
Authors: THOMAS C.  JALESKI
Journal: Annals of Internal Medicine (1944)

Article1 June 1944PANCREATIC LITHIASISTHOMAS C. JALESKI, M.D., F.A.C.P.THOMAS C. JALESKI, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-20-6-940 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe purpose of this paper is to report two cases of pancreatic lithiasis, each of which presents different aspects of the same clinical syndrome. The first case is an alcoholic who showed early disturbance in the sugar metabolism, yet the pancreatic disease had not presented a serious threat to life. The second case succumbed to progressive disease of the pancreas, yet she was not an alcoholic and developed no serious disturbance in sugar metabolism until a few days before death.CASE REPORTSCase 1. (Mrs. A. B.) The patient, a 54 year old white female, had been seen at frequent...Bibliography1. SOMOGYI M: Micromethods for the estimation of diastase, Jr. Biol. Chem., 1938, cxxv, 399. CrossrefGoogle Scholar2. PRATT JH: Diseases of the pancreas, in Oxford Med., 1920, Oxford University Press, New York, Vol. III, p. 473. Google Scholar3. LAZARUS P: Beitrag zur Pathologie und Therapie der Pankreaserkrankungen mit besonderer Berücksichtigung der Cysten und Steine, Ztschr. f. klin. Med., 1904, li, 95. Google Scholar4. BARRON M: The relation of the islets of Langerhans to diabetes with special reference to cases of pancreatic lithiasis, Surg. Gynec. and Obst., 1920, xxxi, 437. Google Scholar5. WITHERSPOON J: Pancreatic lithiasis, South. Med. Jr., 1937, xxx, 1064. CrossrefGoogle Scholar6. SNELLCOMFORT AMMW: The incidence and diagnosis of pancreatic lithiasis, Am. Jr. Digest. Dis., 1941, viii, 237. CrossrefGoogle Scholar7. HEIFETZPROBSTEINGRAY CJJGSH: Clinical studies on blood diastase, Arch. Int. Med., 1941, lxvii, 819. CrossrefGoogle Scholar8. CRANDALL LA: The origin and significance of the blood serum enzymes, Am. Jr. Digest. Dis., 1935, ii, 230. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New Rochelle, New York*Received for publication November 19, 1942. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTuberculosis Occurring in the Course of Chrosic Calcereous PancreatitisDISSEMINATED CALCIFICATION OF THE PANCREAS: REPORT OF TWO CASES*JOHN H. KNEIDEL, M.D. 1 June 1944Volume 20, Issue 6Page: 940-947KeywordsAlcoholicsPancreasPancreatic diseasesProgressive diseases ePublished: 1 December 2008 Issue Published: 1 June 1944 PDF downloadLoading ...
Radiology in Bone Pathology
Authors: Joseph Hanelin, Laurence L. Robbins
Journal: New England Journal of Medicine (1951)

THE DISCOVERY of the roentgen ray gave tremendous impetus to the investigation and clarification of poorly or little understood disease entities and to the recognition of new ones. Of all the body structures the bones were the first to be extensively studied by this means. There has been an understandable lag, however, between the roentgenographic demonstration of bone abnormality and its clinical identification. Progress along these lines is dependent on the correlation of all branches of medicine, — clinical, laboratory, pathologic and radiologic. Recent years have witnessed the reassessment and reclassification of many disease processes. In the identification of any . . .
BACTERIOLOGY.
Authors: S. A. HOPKINS
Journal: JAMA (1896)

I am sorry to be obliged to preface my remarks with an apology, but when I accepted the honor of addressing this society, I had in mind certain original work upon which I was then engaged and which I hoped to have completed in time to lay before you in this paper. I regret to say that in this I am disappointed. As you well know, the demands of science are hard to fulfill. She has little respect for the limitations of time and strength of her votaries. While, therefore, I shall be able to offer you but little in the way of original work, I am very glad to have this opportunity of speaking to you on a subject that is of the deepest interest and significance to me, and which I trust may in its future development prove to be of the greatest practical value to us all.
Joseph Magri
Authors: Tony Jackson
Journal: BMJ (2006)

Paediatrician who became a pioneer in the management of cystic fibrosisTony Jackson made a considerable contribution to the transformation of cystic fibrosis from a fatal disease of infancy to a chronic disease of adults.He applied the developing technology and pharmaceutical developments to everyday practice, supported families and patients, and, after retirement, gave strategic direction to the Cystic Fibrosis Trust research and medical advisory committee, of which he was chairman.The trust awarded him its John Panchaud medal.
Hyponatremia in the syndrome of inappropriate secretion of antidiuretic hormone. Rapid correction with urea, sodium chloride, and water restriction therapy
Authors: G. Decaux
Journal: JAMA (1982)

In the syndrome of inappropriate secretion of antidiuretic hormone (SIADH), rapid elevation of serum sodium concentration may be imperative to correct neurological symptoms. Seven patients with hyponatremia secondary to SIADH were treated by oral intake of two to three doses of 30 g of urea over 24 hours or infusion of 80 g of urea as a 30% solution over six hours, water restriction (500 mL/24 hr), and sodium supplements (120 to 360 mmole/24 hr). Serum sodium concentration increased from 117±2 to 126±1.4 mmole/L (mean±SEM) after eight hours, to 130±1.3 mmole/L after 12 hours, and to 134.5±1.2 mmole/L after 24 hours. The normalization of serum sodium was secondary to osmotic diuresis and to sodium retention induced by urea. Use of urea should be considered when symptomatic hyponatremia in SIADH must be quickly corrected. (<i>JAMA</i>1982;247:471-474)
Upper limit of cerebral blood flow autoregulation in experimental renovascular hypertension in the baboon.
Authors: S Strandgaard, J V Jones, E T MacKenzie, A M Harper
Journal: Circulation Research (1975)

The effect of arterial hypertension on cerebral blood flow was studied by the intracarotid 133Xe clearance method in baboons. The arterial blood pressure was raised in gradual steps with angiotensin. Baboons with renal hypertension of 8-12 weeks duration were studied along with normotensive baboons. In initially normotensive baboons, cerebral blood flow remained constant until the mean arterial blood pressure had risen to the range of 140 to 154 mm Hg; thereafter cerebral blood flow increased with each rise in mean arterial blood pressure. In the chronically hypertensive baboons, cerebral blood flow remained constant until the mean arterial blood pressure had been elevated to the range of 155 to 169 mm Hg. Thus, in chronic hypertension it appears that there are adaptive changes in the cerebral circulation which may help to protect the brain from further increases in arterial blood pressure.
Relationship between plasma benzodiazepine receptor ligand concentrations and severity of hepatic encephalopathy
Authors: A Basile
Journal: Hepatology (1994)

Levels of benzodiazepine receptor ligands were measured in plasma samples from 25 patients in various stages of hepatic encephalopathy due to fulminant liver failure who were not exposed to pharmaceutical benzodiazepines immediately before or during hospitalization. Chromatographic analysis of extracted plasma samples revealed one to nine fractions containing material that competitively inhibited [3H]flumazenil binding to benzodiazepine receptors with the pharmacological properties of benzodiazepine receptor agonists. Two of these peaks were positively identified as the 1,4-benzodiazepines diazepam and N-desmethyldiazepam on the basis of chromatographic, ultraviolet and mass spectral evidence. The plasma levels of diazepam and N-desmethyldiazepam were significantly increased above control values in stage 4 hepatic encephalopathy, whereas total benzodiazepine receptor ligand concentrations were increased above control in stages 1 through 4. A significant but weak linear correlation was found between the relative increase in the levels of diazepam, N-desmethyldiazepam and total benzodiazepine receptor ligands and the severity of hepatic encephalopathy. Thus increased concentrations of benzodiazepine receptor ligands appear to contribute to the enhancement of GABAergic neurotransmission in hepatic encephalopathy, particularly in stage 4. These results constitute further support for a role for benzodiazepine receptor ligands in the pathogenesis of hepatic encephalopathy associated with acute liver failure. (Hepatology 1994;19:112-121).
Editorial Board
Authors: Katrina Lythgoe, Jan Kastelein, Loek De Weerd, Philip Patenall, S Barrett, Canada Bell, B Bohannan, Usa Callaway, S Carpenter, J Clark, P Dayton, A Dobson, M Donoghue, D Erwin, W Laurance, Australia Cairns, R Mace, H May, C Moritz, R Nesse, S Otto, L Partridge, A Read, D Presgraves, B Sheldon, C Simon, B Worm
Journal: Trends in Ecology & Evolution (2009)
Regression of atherosclerosis: preliminary but encouraging news
Authors: J. Henahan
Journal: JAMA (1981)

Drugs, surgery, and possibly changes in smoking behavior can apparently induce a measurable regression of atherosclerosis and other lesions associated with the onset of heart disease in man and animals, according to a series of reports presented at a recent international congress on lipoproteins and coronary atherosclerosis in Lugano, Switzerland. The meeting was sponsored by the European Atherosclerosis Group and the Fondazione Giovanni Lorenzini, Milan, Italy. For example, in rhesus monkeys, Robert W. Wissler, MD, PhD, and Dragoslava Vesselinovitch, DVM, of the University of Chicago's Pritzker School of Medicine, found that a combination of cholestyramine resin, a bile acid sequestering agent, and probucol, a cholesterol-lowering drug, both in wide use clinically, produced major regressions in the size of stherosclerotic lesions within a year. The reduction ensued despite the fact that the animals continued to eat the same high-cholesterol diet that had induced the atherosclerosis in the first place. In the
The Chemical Basis of Growth and Senescence.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Amoxapine Overdosage
Authors: Ken Kulig
Journal: JAMA (1984)

<h3>To the Editor.—</h3> The series of amoxapine overdoses reported by Litovitz and Troutman confirms previously published reports<sup>1-3</sup>that convulsions may occur after overdose of this drug. We must take issue, however, with their statement that amoxapine is "responsible for a disproportionate share of seizures and deaths resulting from cyclic antidepressant overdose." The epidemiologic methods employed in a study such as theirs must clearly demonstrate that the two study groups (patients who overdosed on amoxapine<i>v</i>patients who overdosed on other cyclic antidepressants) are comparable based on age, amount of drug ingested, time from ingestion to treatment, supportive care received, and peak serum levels. Because the authors did not report any comparison data, it is conceivable that they compared adult suicidal patients who ingested massive amounts of amoxapine with a group of patients who may have ingested much smaller doses of other antidepressants. The authors' conclusions would thereby be based
IN PRAISE OF FOLLY
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hypokalemic Periodic Paralysis in a Puerto Rican Black
Authors: Charles D. Johnson
Journal: JAMA (1977)

<h3>To the Editor.—</h3> Hypokalemic periodic paralysis (HPP) is a rare disease; however, descriptions of the entity have appeared in different parts of the world.<sup>1</sup>This case is presented because, to our knowledge, this is the first time that HPP has been described in a Puerto Rican man. <h3>Report of a Case.—</h3> A 30-year-old black Puerto Rican man enjoyed good health until 1974, when he had an unexplained episode of transient paraparesis. On April 22, 1976, he engaged in unusually heavy labor and ate a large amount of cake and ice cream. On the following day, he awoke with weakness of the legs. He was taken to the hospital, where results of a CSF analysis were normal. There was progression of symptoms, as judged by the development of flaccid quadriplegia and dysphagia. He was transferred to our hospital on April 24. There was no history of fever, vomiting, diarrhea, polyuria,
Efficacy of nonoxynol 9 contraceptive sponge use in preventing heterosexual acquisition of HIV in Nairobi prostitutes
Authors: J. Kreiss
Journal: JAMA (1992)

<h3>Objective.</h3> —To determine the efficacy of the nonoxynol 9 contraceptive sponge in preventing sexual acquisition of the human immunodeficiency virus (HIV). <h3>Design.</h3> —Prospective, randomized placebo-controlled trial. <h3>Setting.</h3> —Research clinic for prostitutes in Nairobi, Kenya. <h3>Patients and Interventions.</h3> —One hundred thirty-eight HIV-seronegative women were enrolled, of whom 74 were assigned to nonoxynol 9 sponge use and 64 to placebo use. These two groups did not significantly differ with respect to demographic characteristics, sexual practices, or prevalence of genital infections at enrollment, except for a lower number of sex partners per week and a higher initial prevalence of genital ulcers among women assigned to nonoxynol 9 sponge use. Among the 116 women who returned for follow-up, the mean durations of follow-up were 14 and 17 months for the two groups, respectively. <h3>Main Outcome Measure.</h3> —HIV seroconversion. <h3>Results.</h3> —Nonoxynol 9 sponge use was associated with an increased frequency of genital ulcers (relative risk [RR], 3.3;<i>P</i>&lt;.0001) and vulvitis (RR, 3.3;<i>P</i>&lt;.0001) and a reduced risk of gonococcal cervicitis (RR, 0.4;<i>P</i>&lt;.0001). Twenty-seven (45%) of 60 women in the nonoxynol 9 sponge group and 20 (36%) of 56 women in the placebo group developed HIV antibodies. The hazard ratio for the association between nonoxynol 9 sponge use and HIV seroconversion was 1.7 (95% confidence interval [CI], 0.9 to 3.0). Using multivariate analysis to control for the presence of genital ulcers at enrollment, the adjusted hazard ratio for the association between nonoxynol 9 sponge use and seroconversion was 1.6 (95% CI, 0.8 to 2.8). <h3>Conclusions.</h3> —Genital ulcers and vulvitis occurred with increased frequency in nonoxynol 9 sponge users. We were unable to demonstrate that nonoxynol 9 sponge use was effective in reducing the risk of HIV infection among highly exposed women. (<i>JAMA</i>. 1992;268:477-482)
Oral Surgery
Authors: Kurt H. Thoma
Journal: New England Journal of Medicine (1949)

ANEW era of oral surgery, has begun. In 1945 the American Society of Oral Surgeons appointed a seven-member committee and authorized them to form a certifying board and to conduct examinations for the certification of specialists in oral surgery. The American Board of Oral Surgery was incorporated under the laws of the State of Illinois in 1946 and subsequently approved by the Council on Dental Education of the American Dental Association. The Board conducted its first examinations in February, 1947. Among the qualifications1 required of the applicant are the following:Graduation from a recognized dental school in the United States . . .
ORGANO-THERAPEUTICS IN MENTAL DISEASES.
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Association between Caries and Childhood Lead Exposure
Authors: James R. Campbell, Mark E. Moss, Richard F. Raubertas
Journal: Environmental Health Perspectives (2000)

Epidemiologic studies suggest an association between lead exposure and caries. Our objective was to establish whether children with a higher lead exposure as toddlers had more caries at school age than children with a lower lead exposure. We used a retrospective cohort design. A sample of children who attended second and fifth grades in the Rochester, New York, public schools during the 1995-1996 and 1996-1997 school years were examined for caries through a dental screening program. For each child we assessed the number of decayed, missing, or filled surfaces on permanent teeth (DMFS), and the number of decayed or filled surfaces on deciduous teeth (dfs); the number of surfaces at risk (SAR) was also recorded. Lead exposure was defined as the mean of all blood lead levels collected between 18 and 37 months of age by fingerstick [provided the blood lead level was [less than/equal to] 10 microg/dL)] or venipuncture. A total of 248 children (197 second graders and 51 fifth graders) were examined for caries and had a record of blood lead levels to define lead exposure. The mean dfs was 3.4 (range 0-29); the mean DMFS was 0.5 (range 0-8). Logistic regression was used to examine the association between the proportion of children with DMFS [Greater/equal to] 1, and the proportion with dfs [Greater/equal to] 1, and lead exposure [< 0.48 micromol/L vs. [Greater/equal to] 0.48 micromol/L (< 10 microg/dL vs. [Greater/equal to] 10 microg/dL)] while controlling for SAR, age at examination, and grade in school. For DMFS, the adjusted odds ratio was 0.95 [95% confidence interval (CI), 0.43-2.09; p = 0.89); for dfs, the odds ratio was 1.77 (95% CI, 0.97-3.24; p = 0.07). This study did not demonstrate that lead exposure > 10 microg/dL as a toddler was a strong predictor of caries among school-age children. However, the results should be interpreted cautiously because of limitations in the assessment of lead exposure and limited statistical power.
Renal embolisation in Glanzmann's thrombasthenia.
Authors: E Briet, F J Vismans, A E van Voorthuisen
Journal: BMJ (1980)

Renal embolisation in Glanzmann's thrombastheniaThe bleeding tendency in patients with Glanzmann's thrombasthenia can usually be corrected by platelet transfusions.We report a case in which haematuria did not respond to platelet transfusions but was stopped by renal embolisation.Case report
UMBILICAL ENDOMETRIOMA
Authors: Attilio Galasso
Journal: JAMA (1934)

Attention was called by Babes as early as 1882 to the occurrence of ectopic endometrial tissue in a myoma uteri. In 1883 and 1896 Diesterweg and von Recklinghausen, respectively, wrote on similar observations. These reports were the first of a series by authors who found endometriosis (Sampson) to involve the female adnexa, peritoneum, broad ligaments, abdominal muscles, umbilicus and other viscera. The following is a brief review of the various theories concerning the origin of ectopic endometrial tissue: 1. The wolffian theory. Origin from the mesonephros was supported by von Recklinghausen. This theory held sway until 1903, when Cullen demonstrated that the glandular inclusions in adenomyoma uteri were due to direct invasion of the uterine muscle from the mucosa. 2. The muellerian theory. This conception has been utilized to explain the presence of endometrial tissue in such locations as the umbilicus, inguinal region and rectovaginal septum, on the basis of