tbuckley/cabot-search huggingface dataset:
Uncertainties in Interspecies Extrapolations of Carcinogenicity
Authors: E. A. C. Crouch
Journal: Environmental Health Perspectives (1983)

The usual classification of results of animal carcinogenicity tests is positive or negative. Attempting to observe correlations between species using such results is complicated by differing test sensitivities. In these circumstances it is helpful to use models to represent the experimental data in a consistent way. Fitting the model parameters to the data allows computation of confidence limits and an assessment of concordance or discordance between different species in a way which accounts for differing test sensitivities. This paper describes this approach in detail for one class of models applied to the carcinogenicity test results of 187 of the NCI bioassay series, allowing comparison between B6C3F1 mice, Fischer 344 rats and Osborne Mendel rats. It is shown that the uncertainties in extrapolating between species are larger than generally acknowledged (a standard deviation of a factor of approximately 4.5), but that within these uncertainties there are few if any discordances.
Anachronism
Authors: George N. Braman
Journal: Annals of Internal Medicine (2003)

Ad Libitum5 August 2003AnachronismGeorge N. Braman, MDGeorge N. Braman, MDFrom Bronx, NY 10471.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-139-3-200308050-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail If I were in Time's skin I'd roust aboutAnd play the fool, lead man a merry chase,Spin topsy-turvy and turn inside-out;Let him know who's boss, put him in his place.No past or future would be safe from me;Jumble them together with Krazy GlueOld men would be the boys they long to beAnd youths would wear the years they would pursue.That fishwife putting on her wrinkled capWould be new-born, a belle in fineryCarousing in her young Prince Charming's lap,Her maiden voyage to the winery.In my time-shifting world an old man sings;Baby's ancient wisdom is shared with kings.George ... Author, Article, and Disclosure InformationAffiliations: From Bronx, NY 10471.Current Author Address: George N. Braman, MD, 6142 Delafield Avenue, Bronx, NY 10471. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySafety Assurances for Dietary SupplementsRegulation of Ephedra in the United States 5 August 2003Volume 139, Issue 3Page: 230KeywordsAdolescentsForecasting ePublished: 5 August 2003 Issue Published: 5 August 2003 Copyright & PermissionsCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Nephritis and Lung Hemorrhage
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Areas for quality improvement in pediatric supportive oncology services.
Authors: Jennifer Reichek, Christine B. Weldon, Rani Ganesan, Eugene Suh, Dipti Dighe, Julia Rachel Trosman, Daniel K. Choi, Rosa Berardi, Stacy D. Sanford, Kim Downing, Erika D Owen, Molly Kim, Kathleen Boss, Allison Kniola, Monica Newmark, Natasha Pillay Smiley, Melanie Brown
Journal: Journal of Clinical Oncology (2017)

e22022 Background: In 2013, the Institute of Medicine report recommended that supportive oncology services be initiated at time of diagnosis. Providers of pediatric cancer care in the Chicagoland community, supported by The Coleman Foundation, sought to define areas for quality improvement of supportive oncology delivery to children. Methods: Focus groups and surveys with clinicians providing pediatric cancer care and supportive services at 14 sites were used to prioritize areas needing improvement. Results: 100% (14/14) of sites participated. Of the eligible sites, 6 were pediatric cancer treatment sites and 8 cancer care community organizations. Sites demonstrated consistent agreement for 8 of the 12 areas of focus for improvement. Over 50% of sites reported areas of focus (table) as important or very important. Conclusions: Sites identified the need for quality improvement in delivery of psychosocial, survivorship and palliative care for pediatric cancer patients. Survey results demonstrate a need for collaboration and efforts to guide care delivery improvement across sites. [Table: see text]
Anthrax Inhibitors
Authors: Joan Stephenson
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
GYNERGEN
Authors: E. W. Marti
Journal: JAMA (1930)

<h3>To the Editor:</h3> —We have seen the letter of Mr. Walter R. Fletcher of the British Medical Research Council concerning Gynergen (The Journal, September 6, p. 746). The statement objected to is found in a booklet issued by us early in 1928. It was based on evidence then in our files in New York which evidence, indeed, remained the only one we had up to the time we saw the letter of the British Research Council: namely, passages in the<i>Pharmaceutical Journal</i>of February 20, 1926: "It will be assumed that the therapeutically active substance is the specific alkaloid, ergotamine.... As standard, a sample of ergotamine tartrate is available prepared by the Sandoz Chemical Works.... After consultation with the Director of the Department of Biological Standards, Medical Research Council, it has been decided to approve as good samples of ergot, those containing not less than 1 mg. per gram of
Pediatric Therapy
Authors: Jonathan Trager
Journal: JAMA (1995)

Books on pediatrics abound; there are so many you would be hard pressed to read them all. The major texts, known affectionately as "Nelson's," "Rudolph's," and "Oski," are veritable storehouses of information about childhood ills. For most readers, I suspect, the choice of book comes down to style. But as superb as these texts are, their primary focus is not on the treatment of illness, but rather on the clinical manifestations, pathophysiology, and differential diagnosis of pediatric disease. While they certainly discuss therapy, they are sometimes impractical when it comes to "now I've got a sick child and what exactly do I do?" <i>Pediatric Therapy</i>is one of a handful of books whose sole purpose is to serve as a compendium of therapy for childhood illness, and it has made a solid addition to my library. (Another is<i>Gellis and Kagan's Current Pediatric Therapy</i>, 14th edition, edited by Burg, Ingelfinger,
Interventional Pain Therapy for Intractable Abdominal Cancer Pain
Authors: David P. Seamans, Gilbert Y. Wong, Jack L. Wilson
Journal: Journal of Clinical Oncology (2000)

Article Tools THE ART OF ONCOLOGY: WHEN THE TUMOR IS NOT THE TARGET Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2000.18.7.1598 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 10735909 Interventional Pain Therapy for Intractable Abdominal Cancer Pain David P. SeamansxDavid P. SeamansSearch for articles by this author , Gilbert Y. WongxGilbert Y. WongSearch for articles by this author , Jack L. WilsonxJack L. WilsonSearch for articles by this author Show More From the Department of AnesthesiologyMayo Clinic Scottsdale, Scottsdale, AZ, and Department of Anesthesiology, Mayo Clinic Rochester, Rochester, MN. https://doi.org/10.1200/JCO.2000.18.7.1598 First Page Full Text PDF Figures and Tables © 2000 by American Society of Clinical Oncology
"ENDOTOXIN SHOCK"
Authors: H L WECHSLER
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Book Review Manual of Clinical Mycology. By Norman F. Conant, Ph.D.; Donald S. Martin, M.D.; David T. Smith, M.D.; Roger D. Baker, M.D.; and Jasper L. Callaway, M.D. Prepared under the auspices of the Division of Medical Sciences, National Research Council. 12°, cloth, 348 pp., with 148 illustrations. Philadelphia and London: W, B. Saunders Company, 1944. $3.50.
Journal: New England Journal of Medicine (1945)
The Cover
Authors: M. Therese Southgate
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CIRCUMCISION.
Authors: GEORGE TULLY VAUGHAN
Journal: JAMA (1905)

The operation of circumcision is one of minor importance—except to the individual concerned or to his family, but it is the proper performance of the little things in life that often works for satisfaction or discontent. In view of its ancient origin, it is surprising that some generally accepted method of circumcision has not been devised. Some of the objections to the methods in vogue are the difficulty of keeping the wound aseptic, of the adhesions occurring between prepuce and glans, the sacrifice of too much skin, not leaving enough sometimes to accommodate the organ when erect without uncomfortable stretching, and the bad cosmetic effect when an ugly, ragged, dog-eared, onesided or irregular prepuce is left. The following operation has been performed by me for some years past with very satisfactory results: Attach three hemostats to the margin of the prepuce—one at the frenum and the other two on the sides at equal distances from each other
The Cover
Authors: M. Therese Southgate
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
European Association for Cancer Research (EACR)
Journal: JNCI Journal of the National Cancer Institute (1981)

Journal Article European Association for Cancer Research (EACR) Get access JNCI: Journal of the National Cancer Institute, Volume 67, Issue 2, August 1981, Page 499, https://doi.org/10.1093/jnci/67.2.499-a Published: 01 August 1981
ASSOCIATION INTELLIGENCE
Journal: BMJ (1855)

Ve mattr,; but if an aniual be made diabetic sug will ap.pear i the gmtria juice Thi, howevwer, Dr. Pavy believed to bea remlt of the common impregnation of all the fluids (except the salivay) with sugar.The absenee of sugar from the liver in diebetes he regarded as a result of the cessation of the form.ation of sugar by that organ previously to death.He had been able to produce oxalate of lime in the urine by impeding the
Comparing Alternative Approaches to Establishing Regulatory Levels for Reproductive Toxicants: DBCP As a Case Study
Authors: William Pease, John Vandenberg, Kim Hooper
Journal: Environmental Health Perspectives (1991)

This paper compares four alternative approaches for deriving regulatory levels for reproductive toxicants by applying them to the available data on the human spermatotoxicant 1,2-dibromo-3-chloropropane (DBCP). The alternatives examined include the Proposition 65 approach (application of a mandatory 1000-fold uncertainty factor to a no-observed-adverse-effect level [NOAEL]), the Environmental Protection Agency (EPA) approach (application of flexible uncertainty factors to a NOAEL), the Benchmark Dose approach (application of flexible uncertainty factors to a dose associated with a known level of change in a reproductive parameter), and the Quantitative Risk Estimation approach (using low-dose linear extrapolation and a model of the relationship between sperm count and infertility). Applied to DBCP, these approaches do not produce substantially different estimates of allowable exposure levels. However, the approaches do have different data requirements and provide different amounts of information on reproductive hazards to risk managers and the public. Neither the Proposition 65 nor the EPA approach provides information about the extent of health risk remaining at a regulatory level. In contrast, the Benchmark Dose approach can provide estimates of the magnitude of sperm count reduction at a regulatory level, and the Quantitative Risk Estimation approach can provide estimates of exposure-induced infertility.
Distrust, rage may be 'toxic core' that puts 'type A' person at risk
Authors: C. Raymond
Journal: JAMA (1989)

IT'S NOT talking fast, feeling pressed for time, and putting in long hours that will kill you. It's being suspicious of and hostile toward your fellow humans that will do you in. So finds Duke University Medical Center's Redford B. Williams, Jr, MD, professor of psychiatry at the Durham, NC, campus. Speaking at the annual American Heart Association science writers' forum in Monterey, Calif, he said this distrustful attitude, rather than the sense of time urgency, is the "toxic core" of the renowned Type A personality. The latter, a set of traits originally described by cardiologists Meyer Friedman, MD, and Ray Rosenman, MD (<i>JAMA</i>. 1959;169:1286-1296 and 1984;252:1385-1393), had been thought to increase the risk of coronary heart disease and death until, in the early 1980s, several studies cast doubt on its value as a predictor of risk. For example, the Western Collaborative Study Group reported that Type A persons survived
Is Bt better?
Journal: Environmental Health Perspectives (1997)

EnvironewsForum Is Bt Better?In 1996, U.S. farmers lost approximately $1.5 billion worth of the nation's corn crop to a single pest, the European corn borer.During its larval stage, the corn borer tunnels into corn stalks, interrupting the flow of water and nutrients to the developing ear and reducing grain yield.Tunneling by the larvae also weakens the stalks, causing many to snap and drop ears to the ground, which ruins them for harvest.Because corn borers spend most of their lives inside the corn stalk, they are difficult to control with chemical pesticide sprays.
Errors in Figures
Journal: JAMA Network Open (2021)

In the Research Letter titled "Trends in Heroin Treatment Admissions in the United States by Race, Sex, and Age," 1 published February 5, 2021, panel B in both Figure 1 and Figure 2 were mistakenly given the same y-axis scales as panel A. The y-axis scale in Figure 1, panel B should have been labeled 0 to 400.The y-axis scale in Figure 2, panel B should have been labeled 0 to 700.This article has been corrected.
Recent developments in the treatment of lung cancer
Authors: A. Y. Lin
Journal: JAMA (1992)

SELECTED CASE A 45-year-old asymptomatic white man with a 60-pack-year history of cigarette abuse presented with an upper lobe pulmonary nodule apparent on the right side on a routine chest roentgenogram. Physical examination was unrevealing. Computed tomography demonstrated an irregular noncalcified mass suggestive of neoplasm. Results of transbronchial biopsy were positive for adenocarcinoma. Evaluation for metastases, including a computed tomographic scan of the head, radionuclide bone scan, and serum liver function tests, yielded negative results. The patient subsequently underwent upper lobectomy of the right lung with curative intent and was pathologically staged as having stage I (T2N0)1 adenocarcinoma of the lung. The patient did well until 14 months after surgery, when he developed cough, dyspnea, and hemoptysis. A few days later, he noted a right-sided facial droop, clumsiness of the right hand, blurring of vision, and a severe headache. He presented in the emergency department, where physical examination revealed facial
Investigation of the young hypertensive.
Journal: BMJ (1967)

MEDICAL JOu 569 of the erythema nodosum syndrome and the arthritis of synovial sarcoid infiltration may precede the signs of illness elsewhere.Rheumatic fever, rheumatoid arthritis, and even of gout may be suggested diagnoses in this early phase and may on occasion be supported by nonspecific T-wave changes in the electrocardiogram' or by positive tests for rheumatoid factor due to gammaglobulin changes7 or by elevation of the serum level of uric acid' due to increased cell division.Isolated case reports have probably over- emphasized the importance of these instances of clinical over- lap.Gumpel and his colleagues did not find that they were of much importance in practice.
CLINIC HABITUATION
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal