tbuckley/cabot-search huggingface dataset:
Family Clustering of PBB and DDE Values among Michigan Dairy Farmers
Authors: Mary S. Wolff, Neil Haymes, Henry A. Anderson, Irving J. Selikoff
Journal: Environmental Health Perspectives (1978)

Family clustering of varying levels of serum PBB and DDE was evaluated for 62 Michigan families by using the mean and standard deviation for family units, ranked percentile comparison of family members, and correlation by linear regression of family members. The results indicate that levels of serum PBBs cluster within family units and for children within families. Serum DDE clustering within families occurs only for children. These findings are consistent with recent, interim PBB exposure, perhaps from a common dietary source for families. Serum DDE represents a lifetime, low-level exposure to DDT-DDE which has been both less prolonged and less intense for children. Thus similar levels, or clustered serum DDE, was observed for children within families.
Nouvelle Revue Française d'Hématologie, Paris
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Stimulation of Contraction of Pregnant Rat Uterus in Vitro by Non-Dechlorinated and Microbially Dechlorinated Mixtures of Polychlorinated Biphenyls
Authors: Jeehyeon Bae, Mahmoud A. Mousa, John F. Quensen, Stephen A. Boyd, Rita Loch-Caruso
Journal: Environmental Health Perspectives (2001)

A previous study of six polychlorinated biphenyl (PCB) congeners showed that PCBs with four or fewer chlorines and ortho substitution stimulate uterine contraction frequency in vitro, whereas congeners with a greater number of chlorines or non-ortho substitution are inactive in vitro. We tested the hypothesis that PCB mixtures stimulate uterine contractions in a manner inversely related to the degree of chlorination and the presence of chlorines in the ortho- position of the biphenyl constituents of the mixtures. Uterine strips from pregnant rats were suspended in standard muscle baths and analyzed for changes in isometric contractions in response to in vitro exposure to commercial PCB mixtures (Aroclors) and their dechlorinated products after microbial degradation. The PCB mixtures Aroclor 1242, 1248, and 1254 significantly stimulated uterine contraction frequency, and the least chlorinated mixture, Aroclor 1242, was the most potent stimulant. Microbes from Hudson River sediment dechlorinated Aroclor 1242 and Aroclor 1254 under reducing conditions to produce mixtures with an increased proportion of ortho-substituted congeners with one or two chlorine substitutions. The PCB mixtures that had undergone microbial reductive dechlorination stimulated uterine contraction frequency to a significantly greater extent than the parent mixtures. These results show that increased uterotonic activity was associated with decreased chlorination and increased ortho substitution of the biphenyl constituents of the mixtures.
QuickStats: Age-Adjusted Death Rates,* by Race/Ethnicity† — National Vital Statistics System, United States, 2014–2015
Journal: MMWR Morbidity and Mortality Weekly Report (2017)

From 2014 to 2015, the age-adjusted death rate for the total U.S. population increased 1.2% from 724.6 to 733.1 per 100,000 population. The rate increased 0.6% from 870.7 to 876.1 for non-Hispanic blacks and 1.4% from 742.8 to 753.2 for non-Hispanic whites. The rate for Hispanic persons did not change significantly. The highest rate was recorded for the non-Hispanic black population, followed by the non-Hispanic white and Hispanic populations.
St. Jude Children's Research Hospital Eighteenth Annual Clinical Symposium
Journal: JNCI Journal of the National Cancer Institute (1983)

St. Jude Children's Research Hospital Eighteenth Annual Clinical Symposium Get access JNCI: Journal of the National Cancer Institute, Volume 71, Issue 6, December 1983, Page 1347, https://doi.org/10.1093/jnci/71.6.1347 Published: 01 December 1983
Abstract P433: Associations of CD4+ T Lymphocyte Subpopulations with Insulin Levels and Type 2 Diabetes: The Multi-Ethnic Study of Atherosclerosis (MESA)
Authors: Nels C Olson, Margaret F Doyle, Bruce M Psaty, Ian De Boer, Nancy S Jenny, Richard A Kronmal, Russell P Tracy
Journal: Circulation (2013)

Background: Chronic inflammation is a characteristic feature of insulin resistance (IR) and type 2 diabetes (T2D). Elevated circulating levels of pro-inflammatory cytokines, such as interleukin-1 beta (IL-1β) and interleukin-6 (IL-6), are predictive of disease onset suggesting contributions of adaptive immune responses in the etiology of T2D. Therefore, we hypothesized that increased populations of CD4 + effector/memory (EM) and T helper 1 (Th1) cells, and decreased populations of CD4 + naive cells, would be associated with high insulin levels and an increased risk of T2D. Methods: T cell subpopulations were measured in peripheral blood by flow cytometry, using CD4 + CD45RO + , CD4 + CD45RA + , CD4 + IFN-γ + , and CD4 + IL4 + as markers for EM, naive, Th1, and Th2 cells, respectively. Data for each subpopulation were reported as a percent of total CD4 + cells. Associations were explored with components of the metabolic syndrome, insulin measures, and type 2 diabetes in a random subset ( n =917) of the Multi-Ethnic Study of Atherosclerosis (MESA). T2D was defined by fasting glucose ≥126 mg/dL or use of glucose-lowering medications ( n =151). All variables were measured at Exam 4 (2005-2007), except for insulin which was measured at Exam 5 (2010-2012), and inflammatory biomarkers measured at Exam 1 (2000-2002). Results: Naive cells were inversely, and EM, and Th1 cells positively associated with insulin levels in minimally adjusted (age, gender, race/ethnicity) linear regression analyses that modeled insulin as the dependent variable. No significant associations were observed with Th2 cells. After further adjustment for the metabolic- and cardiovascular disease (CVD)-related variables, waist circumference, systolic blood pressure (BP), use of anti-hypertensive medication, smoking status, total- and HDL-cholesterol, use of lipid lowering medication, and IL-6, the association of insulin with Th1 cells, but not naive or EM cells, remained significant [β= 6.4 mU/L (± 1.69 mU/L) per standard deviation (SD) increase in Th1 cells (8.3%); p=0.0002]. Adjusting for body mass index (BMI) in place of waist circumference did not alter interpretation of the results. In standardized logistic regression models including cell subpopulations and metabolic- and CVD-related variables (as above) as the independent variables, naive cells were inversely associated with prevalent T2D [odds ratio (95% confidence interval)=0.78 (0.61-0.99)]. Conclusion: Increased populations of Th1 cells and decreased populations of CD4 + naive cells are associated with insulin levels and T2D, respectively, independent of measures of adiposity. These cross-sectional findings suggest that excess immune activation and Th1 bias, as reflected by these differences, may contribute to the etiology of IR and T2D.
Efficacy of Budesonide/Formoterol Pressurized Metered-Dose Inhaler in Patients With Moderate to Severe Asthma With and Without Fixed Airflow Obstruction
Authors: D.P. Tashkin, B.E. Chipps, T. Uryniak, S. Zhao, J.G. Zangrilli
Journal: Journal of Allergy and Clinical Immunology (2012)
A phase IB/II study of second-line therapy with panitumumab, irinotecan and everolimus (PIE) in metastatic colorectal cancer (mCRC) with KRAS wild type (WT)
Authors: A. Townsend, N. Tebbutt, C. Karapetis, P. Cooper, N. Singhal, S. Yeend, L. Pirc, R. Joshi, T.J. Price
Journal: Annals of Oncology (2016)
THE ANTITOXIN PRODUCTION.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Massachusetts Medical Society
Authors: John Figgis Jewett
Journal: New England Journal of Medicine (1956)

COMMITTEE ON MATERNAL WELFAREIntestinal Obstruction after Cesarean SectionA thirty-three-year-old gravida II, para I, had had a cesarean section for premature separation of the placenta two years before. The postoperative course had been complicated by wound dehiscence on the fourth day, but she recovered. Recently, she had been hospitalized for intestinal obstruction, but not operated on. On the fifth day of her last menstrual period she was again hospitalized, and laparotomy was performed. The small bowel was accidentally opened when the abdomen was entered since it was adherent to the abdominal wall, but there was no true intestinal obstruction. . . .
A Correction.
Authors: Frank Allport
Journal: JAMA (1896)

Minneapolis, April 19, 1896. <h3>To the Editor:</h3> —In your report of the proceedings of the Tri-State Medical Society, in your last issue, I am so grossly misrepresented in what I said, that I must beg you to place this brief correction in your next issue. The title of my paper was "The Relationship Existing Between Oculists and Opticians." You quote me as saying that I "advanced strong arguments in favor of licensing opticians to<i>fit</i>glasses." Had you said "<i>dispense</i>" instead of "<i>fit</i>," you would have expressed my sentiments. There is as much difference between dispensing and fitting glasses, as there is between dispensing and prescribing medicine; and the optician should occupy the same relation to an oculist, that a druggist does to the general and special medical practitioner, viz., a preparer and dispenser of specified remedies (glasses), upon the receipt of a physician's (oculist's) written prescription. I claim that
The Cover
Authors: Mary Jackson Harvey
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The WAVE2 complex regulates T cell receptor signaling to integrins via Abl- and CrkL–C3G-mediated activation of Rap1
Authors: Jeffrey C. Nolz, Lucas P. Nacusi, Colin M. Segovis, Ricardo B. Medeiros, Jason S. Mitchell, Yoji Shimizu, Daniel D. Billadeau
Journal: The Journal of Experimental Medicine (2008)
The Case of the Itching Tattoo
Authors: J. R. E.
Journal: Annals of Internal Medicine (1967)

Editorial Notes1 November 1967The Case of the Itching TattooJ. R. E.J. R. E.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-67-5-1116 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe tattooed lady, that legendary attraction of the circus, had better keep out of the sun—she might get the itch. For years it has been known that tattoos containing red pigment may develop an itching eczema, warty nodules, and even sarcoid-like granulomas. Because the red pigment employed in the main by tattoo artists is cinnabar—mercuric sulfide—this allergic reaction usually has been assumed to be a manifestation of mercurial hypersensitivity set off by a subsequent exposure to mercury in any of a variety of forms (1). But such exposure has often been hard to establish, and concomitant systemic sarcoidosis has never...References1. BEERMANLANE HRA: "Tattoo": a survey of some of the literature concerning the medical complications of tattooing. Amer. J. Med. Sci. 227: 444, 1954. CrossrefMedlineGoogle Scholar2. GOLDSTEIN N: Mercury-cadmium sensitivity in tattoos: a photoallergic reaction in red pigment. Ann. Intern. Med. 67: 984, 1967. LinkGoogle Scholar3. DOYLE AC : "The Red-headed League," in The Complete Sherlock Holmes. Garden City Publishing Co., Inc., Garden City, N. Y., p. 196. Google Scholar4. GOLDMANROCKWELLMEYEROTTENWILSONKITZMILLER LJRRRGKW: Laser treatment of tattoos. JAMA 201: 841, 1967. CrossrefMedlineGoogle Scholar5. Sherlock Holmes' first case (when he was in college) turned on the clue of an unsuccessfully obliterated tatoo (see "The Gloria Scott," in book cited in reference 3, p. 432). Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1967Volume 67, Issue 5Page: 1116-1117KeywordsAllergy and immunologyEczemaGranulomasHypersensitivityPruritusSarcoidosis ePublished: 1 December 2008 Issue Published: 1 November 1967 PDF downloadLoading ...
CHANGE OF HEART
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Radiation Retinopathy
Authors: Paul R. Gliedman
Journal: JAMA (1987)

<h3>To the Editor.—</h3> We read with great interest Dr Jampol's<sup>1</sup>excellent description of radiation retinopathy and its treatment in the Nov 14 issue ofThe Journal. He is correct in his assertion that it can be a complication following high-dose radiotherapy to the retina; however, his assumption that the patient in question must have received such a dose is not justified. While we do not know the details of this patient's radiotherapy, it is very unlikely that the patient was treated with a dose sufficient to lead to radiation retinopathy. There exists a body of literature detailing the technique and results of radiotherapy in Graves' ophthalmopathy. A customary dosage of radiation for this disease is 2000 rad (20 Gy) given in ten fractions over a two-week period. This dosage would be expected to lead to improvement or at least stabilization of the disease in the vast majority of patients.
<i>Erratum:</i> Vol. 69, No. 29
Journal: MMWR Morbidity and Mortality Weekly Report (2020)

In the report, "Population Point Prevalence of SARS-CoV-2 Infection Based on a Statewide Random Sample -Indiana, April 25-29, 2020," on page 961, the sentence beginning at the bottom of the first column should have read "Statewide, 1.74% of persons (unweighted n = 47) had a positive RT-PCR test result (95% CI = 1.10%-2.54%),and 1.01% (95% CI = 0.76%-1.45%)(unweighted n = 38) had samples that were seropositive, resulting in an estimated overall population SARS-CoV-2 prevalence of current or previous infection in Indiana of 2.79% (95% CI = 2.02%-3.70%)."
Allergy abstracts
Authors: David Stein Sujjk~, Harold Friedman, Ohio Monroe, Coleman Stamford, Conn Eugene, Walzer Bridgeport, Freehold Berger, Tex Tyler, J Andre, N Codispoti Suflem, C Juana, Neil Goldman, Yorktown Heights, N Mural1
Journal: Journal of Allergy and Clinical Immunology (1982)
Stroke
Authors: Jonathan Z. Charney
Journal: JAMA (1978)

As the editors mention, stroke is one of the three major causes of death in major neurology and neurosurgery centers. This publication represents an update of information concerning the basic aspect of stroke, the treatment of ischemic stroke, and the treatment of hemorrhagic stroke. The book condenses the material presented in the annual continuing education course sponsored by the Barrow Neurological Institute in Phoenix, Ariz. The authors include some of the leading authorities in the field of cerebrovascular disease. They present and discuss their findings in their own particular field of expertise. Many of the modalities are still widely debated among neurologists, but both sides of many important and controversial issues are presented. Particularly good are the chapter by Norman Chater and A. John Popp on newer neurosurgical procedures, such as microsurgical vascular bypasses; the chapter by Charles Drake entitled "Advances in the Neurosurgical Treatment of Aneurysms, Arteriovenous Malformations, and
Leukemia in Children: Incidence, Clinical Manifestations, and Survival in Unselected Series
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Role of hepatitis C virus in dual and triple hepatitis virus infection
Authors: Yun-Fan Liaw
Journal: Hepatology (1995)

Hepatitis B virus (HBV), hepatitis C virus (HCV), and hepatitis delta virus (HDV) share same transmission routes, thus dual or triple infection may occur and even persist in the same patients. A significant amount of literature has accumulated since the advent of HCV assays. It is pertinent to review and evaluate the clinical and virological significance of HCV in multiple hepatotropic viral infection. The reported series on seroprevalence of HCV indicate that HCV is found in more than 10% of HBV- or HDV-infected patients worldwide. Of the patients with dual or triple infection involving HCV, those having coreplication of viruses tend to have severe and progressive liver disease that is resistant to interferon therapy, in contrast with patients having a single virus infection. Paradoxically, dual or triple hepatitis virus infections are associated with viral interference. In particular, HCV exerts a suppressive effect on HBV and HDV and may enhance seroclearance of HBV antigens or even usurp the role of preexisting virus as the agent for continuing hepatitis. Although HBV and HDV may also suppress HCV, it appears to be less effective. These findings clearly suggest the necessity of monitoring patients with HBV or HDV infections. In view of complex dynamism of viral interaction in multiple hepatotropic virus infection, the importance of HCV assay in the clinical studies can not be overemphasized. The basic mechanisms that regulate the viral interactions, in particular the impact of HCV in dual or triple virus infections, remain to be investigated. (Hepatology 1995; 22:1101-1108.).