tbuckley/cabot-search huggingface dataset:
Treatment of Diabetes Mellitus: Statistical Data Based on a Summary of 1,190 Cases
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Understanding the Combined Effects of Conventional Risk Factors and Genetic Loci on Diabetes Incidence
Authors: Marilyn C. Cornelis
Journal: Annals of Internal Medicine (2009)

Letters1 December 2009Understanding the Combined Effects of Conventional Risk Factors and Genetic Loci on Diabetes IncidenceMarilyn C. Cornelis, PhD and Frank B. Hu, MD, PhDMarilyn C. Cornelis, PhDFrom Harvard School of Public Health, Boston, MA 02115.Search for more papers by this author and Frank B. Hu, MD, PhDFrom Harvard School of Public Health, Boston, MA 02115.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-151-11-200912010-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Dr. Kim's comments highlight some of the challenges of combining genetic and conventional risk factors. Such challenges will persist as new loci with modest effects on risk continue to be discovered.Limited space did not allow us to provide details on how genetic loci and conventional risk factors were related. Obesity is an important risk factor to consider in understanding the mechanism by which these loci contribute to diabetes development. None of the 10 loci included in the GRS were related to BMI or the remaining conventional risk factors (age, smoking, alcohol use, physical activity, menopausal status, and ...References1. Lyssenko V, Jonsson A, Almgren P, Pulizzi N, Isomaa B, Tuomi T, et al. Clinical risk factors, DNA variants, and the development of type 2 diabetes. N Engl J Med. 2008;359:2220-32. [PMID: 19020324] CrossrefMedlineGoogle Scholar2. Meigs JB, Shrader P, Sullivan LM, McAteer JB, Fox CS, Dupuis J, et al. Genotype score in addition to common risk factors for prediction of type 2 diabetes. N Engl J Med. 2008;359:2208-19. [PMID: 19020323] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Harvard School of Public Health, Boston, MA 02115.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoJoint Effects of Common Genetic Variants on the Risk for Type 2 Diabetes in U.S. Men and Women of European Ancestry Marilyn C. Cornelis , Lu Qi , Cuilin Zhang , Peter Kraft , JoAnn Manson , Tianxi Cai , David J. Hunter , and Frank B. Hu Understanding the Combined Effects of Conventional Risk Factors and Genetic Loci on Diabetes Incidence Jongoh Kim Metrics 1 December 2009Volume 151, Issue 11Page: 825KeywordsAlcoholsBody mass indexClinical geneticsConflicts of interestExerciseGeneticsGlucoseInsulin resistanceMedical risk factorsObesity ePublished: 1 December 2009 Issue Published: 1 December 2009 CopyrightCopyright © 2009 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Malpractice Claims and Physicians' Communication Patterns
Authors: Gerard W. Frank
Journal: JAMA (1997)

<h3>To the Editor.</h3> —Dr Levinson and collegues<sup>1</sup>present interesting results on the relationship of physician-patient Communication with malpractice claims among primary care physicians and surgeons. However, they did not mention a major limitation of their study—the issue of the routine visit. Primary care physician visits in their study lasted a mean of 16.5 minutes (SD, 5.7 minutes). It is very difficult to believe that the average length of a primary care visit in the era of managed care is 16.5 minutes; I suspect visit length today is much shorter in some primary care settings. Either the authors' sample was quite atypical or the physicians in their study made a special effort to talk longer while being taped. Both possibilities would be a major limitation. Richard Balon, MD Detroit, Mich <h3>To the Editor.</h3> —While fascinating, the study by Dr Levinson and colleagues<sup>1</sup>is curious in that it attempts to
Diagnostic Neuroradiology
Authors: Bernard S. Wolf
Journal: JAMA (1976)

This second edition of<i>Diagnostic Neuroradiology</i>by Taveras and Wood follows the first edition by ten years. It is still designated as section 1 of Golden's<i>Diagnostic Radiology</i>series, although it is a freestanding text. Despite a reduction in total number of pages, this edition is in two volumes instead of the original one. The original parts—"Skull," "Intracranial Pneumography," "Cerebral Angiography," "Selection of Diagnostic Procedure," "Diseases of the Spinal Cord"—have been kept, and one new part—"Inflammatory Conditions of the Central Nervous System"—has been added. New and detailed information on the vertebral-basilar system, normal and pathological anatomy of the intermediate and venous phases of cerebral angiograms, angiography of the spinal cord, and dynamic observations during serial filming has been included. The section on head injuries has been expanded. Technical refinements such as subtraction, magnification, and television fluoroscopic monitoring are described and new excellent illustrations added. The readability of the text is
Complicationes Diabetic Presentante como le Manifestation Clinic Initial de Diabete
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Biology enters repressed memory fray
Authors: P. Cotton
Journal: JAMA (1994)

SCIENCE is starting to shed light on the bitter debate over "false" vs "repressed" memories of abuse. There is now wide acknowledgment that false memories can develop and be brought out or even created during therapy. There is also a growing body of evidence from more than a dozen prospective studies that memory impairment is common during or because of traumas ranging from earthquakes to rape. And studies are documenting down to the molecular level how memory can be impaired by trauma. "We are learning that when a person, particularly a child, is severely traumatized, it is not so much the external event but the internal experience of what is happening" that determines the extent of trauma and possibility of memory impairment, says Charles R. Marmar, MD, a professor of psychiatry at the University of California—San Francisco, School of Medicine and president of the International Society for Traumatic Stress Studies.
Targeting MAPK Signaling Pathway with Cobimetinib (GDC-0973) Enhances Anti-Leukemia Efficacy of Venetoclax (ABT-199/GDC-0199) in Acute Myeloid Leukemia Models
Authors: Lina Han, Qi Zhang, Ce Shi, Antonio Cavazos, Vivian Ruvolo, Joel Leverson, Dail Monique, Darren C. Phillips, Jun Chen, Sha S Jin, Rodrigo Omar Jacamo, Naval Daver, Elias J. Jabbour, Hagop M. Kantarjian, Michael Andreeff, Deepak Sampath, Marina Konopleva
Journal: Blood (2016)
Respiratory failure in neuromuscular disease. Management in a respiratory intensive care unit
Authors: W. J. O'Donohue
Journal: JAMA (1976)

Patients with neuromuscular disease frequently experience acute respiratory failure. Most require endotracheal intubation or tracheostomy and mechanical ventilation because of paralysis and inability to maintain adequate spontaneous respiration. The prognosis is usually excellent if ventilatory management is successful. (<i>JAMA</i>235:733-735, 1976)
Diseases of Children. A Manual for Students and Practitioners.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Book Review The Pharmacological Basis of Therapeutics: A textbook of pharmacology, toxicology and therapeutics for physicians and medical students . By Louis Goodman, M.D., and Alfred Gilman, Ph.D. 4°, cloth, 1383 pp., with 126 illustrations and 67 tables. New York: The Macmillan Company, 1941. $12.50.
Journal: New England Journal of Medicine (1942)
A phase I study of an agonist anti-CD27 human antibody (CDX-1127) in patients with advanced hematologic malignancies or solid tumors
Authors: Stephen Ansell, Donald Northfelt, Ian Flinn, Howard Burris, Shira Dinner, Victor Villalobos, Branimir Sikic, Lana Pilja, Michael Yellin, Tibor Keler, Thomas Davis
Journal: Journal for ImmunoTherapy of Cancer (2013)

Meeting abstracts CD27, a member of the tumor necrosis factor receptor superfamily, is constitutively expressed on the majority of mature T cells, memory B cells, and a subset of NK cells. We previously demonstrated anti-tumor and immunological properties of the fully human anti-CD27 mAb 1F5 (CDX-
Resident malpractice involvement debated by AMA-RPS
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Splenectomy in renal transplantation. Influence on azathioprine sensitivity
Authors: J. E. Woods
Journal: JAMA (1971)

A retrospective study of renal allografted patients revealed that the incidence of azathioprine (Imuran)-induced leukopenia in nonsplenectomized patients was significantly higher than in patients splenectomized prior to transplantation. In two patients whose case histories are presented, there was a marked increase in tolerance to azathioprine when splenectomy was performed for leukopenia after transplantation.
Patients with treatment resistant hypertension do take their drugs
Journal: BMJ (2001)

Increased risk of thrombosis with third generation oral contraceptives is realA meta-analysis has shown that third generation oral contraceptives carry a 1.7-fold higher risk of venous thromboembolism than second generation pills.Kemmeren et al (p 131) pooled the results of studies that collected data up to October 1995, when four studies highlighted the possible risk of third generation oral contraceptives (containing desogestrel or gestodene).The increase in risk was greatest in first time users and could not be accounted for by biased selection of study groups or in other flaws in design and analysis of the studies.
Myocardial Infarction in Men
Authors: Charles W. Frank
Journal: JAMA (1966)

The Health Insurance Plan of Greater New York study of coronary heart disease involves a defined population of some 110,000 adult men and women. In the first 18 months of the study, 301 men suffered an initial myocardial infarction, with a four-week case fatality rate of 32%. The focus of interest in the current report is the relationship of smoking habits and customary level of physical activity at time of infarction to both incidence and early mortality. Age-adjusted incidence rates are presented for smokers and nonsmokers of differing physical activity levels. Smokers exhibit an excess incidence rate for first myocardial infarction, but the case fatality rate is no higher than for nonsmokers. The "least active" men show both an increased incidence and a higher case fatality rate. The incidence of rapidly fatal myocardial infarction among "least active" smokers is nine times that found among the more active nonsmokers.
NCI trial hearing elicits vow of more oversight
Authors: C. Marwick
Journal: JAMA (1994)

A CONTRITE quintet of National Institutes of Health administrators have told Congress that never again will they allow fraudulent data from studies to go uncorrected and unreported in the professional literature—even if they think there is little medical or public health significance. The occasion was a hearing held by Rep John D. Dingell (D, Mich), chair of the Subcommittee on Investigations and Oversight of the House Energy and Commerce Committee. At issue was the failure of the National Cancer Institute (NCI) to adequately disseminate to the scientific community, and especially to the participants, the finding that data regarding some patients in one center of a multicenter study of breast cancer treatment were falsified. The fact that this fabrication did not affect the findings of the study was, hearing participants agreed, no excuse. "It is very clear that the methods used to announce the results of this misconduct were not adequate,
Barrier-method contraceptives and pelvic inflammatory disease
Authors: J. Kelaghan
Journal: JAMA (1982)

The protective effect of barrier-method contraception against pelvic inflammatory disease (PID) was examined by analyzing data from the Women's Health Study, a large multicenter case-control study. We compared the contraceptive methods used by 645 women hospitalized for initial episodes of PID with the contraceptive methods used by 2,509 control subjects reporting no history of PID. The risk of hospitalization for PID in women currently using barrier methods relative to women using all other methods and to women using no method of contraception was 0.6 (95% confidence limits, 0.5 to 0.9) for both comparisons. This protective effect was observed for both chemical and mechanical barrier methods, although it was not statistically significant for the former. The prevention of PID and its sequelae is one of the most important noncontraceptive benefits of barrier methods of contraception. (<i>JAMA</i>1982;248:184-187)
Diabetic pregnancy.
Authors: N L Essex, D A Pyke, P J Watkins, J M Brudenell, H R Gamsu
Journal: BMJ (1973)

Control of DiabetesDuring the last two decades about 35 diabetic women a year have been delivered at King's College Hospital.Most of the patients were regular attenders at the diabetic clinic, but some were referred from other centres specifically for the manage- ment of the pregnancy.
Obstetrics History
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Radiotherapy and oncology.
Authors: T B Brewin
Journal: BMJ (1983)

The metabolic disposition of recainam, an antiarrhythmic drug, was compared in mice, rats, dogs, rhesus monkeys, and humans. Following oral administration of [14C]recainam-HCl, radioactivity was excreted predominantly in the urine of all species except the rat. Metabolite profiles were determined in excreta by HPLC comparisons with synthetic standards. In rodents and rhesus monkeys, urinary excretion of unchanged recainam accounted for 23-36% of the iv dose and 3-7% of the oral dose. Aside from quantitative differences attributable to presystemic biotransformation, metabolite profiles were qualitatively similar following oral or iv administration to rodents and rhesus monkeys. Recainam was extensively metabolized in all species except humans. In human subjects, 84% of the urinary radioactivity corresponded to parent drug. The major metabolites in mouse and rat urine and rat feces were m- and p-hydroxyrecainam. Desisopropylrecainam and dimethylphenylaminocarboxylamino propionic acid were the predominant metabolites in dog and rhesus monkey urine. Small amounts of desisopropylrecainam and p-hydroxyrecainam were excreted in human urine. Selective enzymatic hydrolysis revealed that the hydroxylated metabolites were conjugated to varying degrees among species. Conjugated metabolites were not present in rat urine or feces, while conjugates were detected in mouse, dog, and monkey urine. Structural confirmation of the dog urinary metabolites was accomplished by mass spectral analysis. The low extent of metabolism of recainam in humans suggests that there will not be wide variations between dose and plasma concentrations.
Imaging of the Liver
Journal: Hepatology (2013)

cell migration/invasion induced by TGFβ1/2 in HepG2 cells.CA increased the nuclear protein levels of Nrf2, total protein levels of SIRT1, and phosphorylation of PTEN in HepG2 cells.However, CA did not influence the effects of TGFβ1/2 on the protein levels of E-cadherin and phosphorylation of SMAD2.Discussion: Our data indicate that CA protects against oxidative stress-induced cytotoxity and inhibits TGFβ-induced migration and invasion.MAPK, Nrf2, SIRT1, and PTEN may be involved in the ativity of CA.
Medical Schools
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal