tbuckley/cabot-search huggingface dataset:
PRECAUTIONS IN AUTOPSY AND EMBALMING PROCEDURES FOLLOWING THE ADMINISTRATION OF RADIOISOTOPES
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Circles
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hypoglycaemia in infancy and childhood.
Authors: J M Robertson, A D Griffiths
Journal: BMJ (1971)

Mr. A. R. Gurd (personal communication) has shown that the insertion of cemented or non-cemented prostheses, or Kuntchner nails, all produce similar and marked in- creases in the levels of fat in blood from the femoral vein.It is not surprising that fat is frequently found in the pulmonary vessels of these patients postoperatively.Not much significance can be attached to this finding unless it is combined with an assessment of cardiopulmonary function.Dr. Gresham and colleagues do not comment on fat in the systemic circulation of the patients who died following Thompson prostheses.Patients undergoing femoral head replace- ment with Thompson prostheses are generally old, with pre-existing cardiopul- monary disorders.They are subjected to a second severe episode of stress at operation within a variable interval of the original trauma.A higher mortality rate in these patients compared to those undergoing total hip replacement may be related to the un- satisfactory general condition of the former and to the fact that they are suffering a second episode of stress.-Weare, etc.,
Campylobacter infections today
Authors: S. Levin
Journal: JAMA (1985)

In the 1960s, fewer than 25% of persons with acute diarrhea had a pathogen identified by stool examination. Today, as many as 65% to 85% of patients have a causative agent identified.<sup>1</sup>In addition to better culturing techniques, new organisms have been discovered. Among these,<i>Campylobacter jejuni</i>is the most important. Finch and Riley<sup>2</sup>estimated that more than 16,000 people acquired<i>Campylobacter</i>infections in the United States in 1982. Diarrhea caused by<i>Campylobacter</i>was as common as<i>Salmonella</i>and more common than<i>Shigella</i>. These results are even more striking because many laboratories did not culture for the organism or report it. For comparison,<i>C jejuni</i>infections in the United States in 1982 are estimated to have occurred at a rate roughly equal to that of hepatitis B, ten times that of influenza, and 30 times that of legionnaires' disease.<sup>3</sup> The nomenclature for<i>Campylobacter</i>organisms has changed recently
Treatment of herniated lumbar disk syndrome with chymopapain
Authors: M. J. Javid
Journal: JAMA (1980)

One hundred twenty-four patients with herniated lumbar disks received intradiskal injections of chymopapain before the Food and Drug Administration's withdrawal of the drug. One year after injection, 90 patients (72.6%) experienced major improvement, 21 (16.9%) had slight improvement, and 13 (10.5%) had no improvement. Of those patients who had no previous back surgery and who were not compensation cases, 77 patients (81%) had marked improvement, 13 (13.7%) had slight improvement, and five (5.3%) had no improvement. Three- to six-year follow-ups were obtained by questionnaire. Of the 114 patients responding, overall 83 patients (72.8%) had marked improvement, and 75 (83.3%) of those with no previous surgery and who were not workmen's compensation cases had major improvement. Since all patients met objective criteria for diskectomy, favorable results from chemonucleolysis spared most the trauma of surgery and its attendant convalescence. These results indicate that chemonucleolysis can and should be considered an advantageous alternative to surgery in appropriately selected patients. (<i>JAMA</i>243:2043-2048, 1980)
HYPERCALCEMIA—DOUBLED CAUSES AND A DILEMMA
Authors: E. J. H.
Journal: Annals of Internal Medicine (1961)

ExcerptTwelve years ago, Albright and Reifenstein set forth most of the now-known clinical causes of hypercalcemia in their monograph1 on metabolic bone disease. Since then the list (Table 1) has grown only by the addition of "hyperthyroidism" and "neoplasm without skeletal lesions." Even the latter cause was anticipated by Albright in his case 5, "Hypernephroma with solitary metastasis to bone simulating hyperparathyroidism." But diagnosing the cause of an elevated serum calcium level has become an increasinglycomplex problem in the past decade, due to the appearance of cases with less overt signs and symptoms and of cases with multiple causes...
Adrenal Medullary Stimulation Induced by Angiotensin I, Angiotensin II, and Analogues
Authors: MICHAEL J. PEACH
Journal: Circulation Research (1971)

A structure-activity relationship study was attempted to determine the structural specificity of the no. 8 amino acid residue of [1-asp,5-ileu]-angiotensin II for adrenal medullary stimulation. Isolated cat adrenal glands were perfused retrograde at a flow rate of 1 ml/min with phosphate-buffered Locke's solution at 23 to 25 C. Continuous catecholamine analysis was performed using an automated trihydroxyindole procedure. All drugs were administered either by single injection (0.05 to 0.1 ml) or by perfusion. Angiotensin analogues studied were: [8-(OMe)tyr]-angiotensin II; [8-tyr]-angiotensin II; [8-ala]-angiotensin II; [5-ileu,8-(3-amino-4-phenylbutyric acid)]-angiotensin II (referred to as [8-APB]-angiotensin II); [5-ileu,8-(DL-3-amino-3'-phenylisobutyric acid)]-angiotensin II (referred to as [8-APIB]-angiotensin II); [1-asp(NH 2 ),5-val]-angiotensin II; [1-asp,5-ileu]-angiotensin I; tetradecapeptide. Three peptides (angiotensin II, [8-tyr]-angiotensin II, and [8-ala]-angiotensin II) were studied in vivo for stimulation of adrenal catecholamine secretion. For maximum pressor activity, angiotensin must be an octapeptide with an aromatic amino acid and free COOH group in the no. 8 position. None of these three are structural requirements in adrenal chromaffin tissue. There was cross-tachyphylaxis between angiotensin II and all the analogues studied except two ([8-APB]- and [8-APIB]-angiotensin II). In vitro studies with 10-leu-C 14 -angiotensin I and angiotensin II antibody indicated that angiotensin I has a marked, direct stimulatory effect on the adrenal medulla. Adrenal medullary catecholamine secretion induced by angiotensin I and II was greatly potentiated by DMAE perfusions. Responses to nicotine were blocked by DMAE and bradykinin-induced catecholamine release was unchanged. The cross-tachyphylaxis and DMAE studies suggest that several of the analogues and angiotensin II are interacting with a common adrenal medullary receptor.
Socially tolerable cigarette smoke?
Authors: F. Homburger
Journal: JAMA (1979)

The first issue raised by Dr Homburger on our recent article inThe Journalis the possible alteration in the proportion of toxic smoke constituents of today's cigarettes compared with pre-1960 cigarettes. The formulation of today's low tar and low nicotine cigarettes is carried out by processes that reduce quantitatively, and largely nonselectively, the amount of smoke produced in both the particulate phase (which contains tar, nicotine, and water) and the gas phase (which contains the other smoke constituents). Table 3 of our article suggests this overall quantitative reduction, in that the six constituents addressed are reduced for each of the cigarette brands listed. The constituents considered were chosen because these have been implicated in human disease incidence. These and other constituents have been addressed by the National Cancer Institute's Smoking and Health Program, where over 130 types of experimental cigarettes have been tested for potentially lower toxicity.
EDITORIAL.
Journal: JAMA (1884)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Problems in Reporting Psychiatric Disorders Among Homeless Adults
Authors: Michael R. Fischetti
Journal: JAMA (1990)

<h3>To the Editor.—</h3> In the September 8, 1989, issue of<i>JAMA</i>, Breakey et al<sup>1</sup>present data on psychiatric disorders among a sample of 125 homeless men and 78 women from Baltimore, Md, missions, shelters, and jails. While this cross-sectional study uses standardized clinical diagnostic tools and addresses the important issue of comorbidity, it has been misinterpreted by the media and public policy advocates owing to several analytic shortcomings. First, using the<i>Diagnostic and Statistical Manual of Mental Disorders, Third Edition</i>to estimate overall prevalence of psychiatric disorders, the authors report that 91% of men and 80% of women received an Axis I diagnosis—a statistic that was translated into major news by the Sunday<i>New York Times</i>(September 10, 1989) and the Associated Press. These statistics may be accurate estimates of the overall burden of disability associated with homelessness, yet they are of limited value because they aggregate the
Inhibition of woodchuck hepatitis virus replication by adenine arabinoside monophosphate coupled to lactosaminated poly--lysine and administered by intramuscular route*1
Authors: L FIUME
Journal: Hepatology (1995)

We prepared a hepatotropic conjugate, suitable for intramuscular (IM) injection, of lactosaminated poly-Llysine with adenine arabinoside monophosphate (araAMP), a drug active against hepatitis B virus (HBV). We studied its organ distribution in mice and its antiviral activity in woodchucks that are carriers of woodchuck hepatitis virus (WHV). In mice, after IM administration of a conjugate tritiated in the drug moiety (5.2 μg/g equal to 2 μg/g of ara-AMP) radioactivity in liver was three times greater than in kidney, spleen, and intestine. On the contrary, after IM injection of unconjugated, tritiated, ara-AMP (5 μg/g) the amounts of radioactivity in liver, spleen, and kidney were similar. Unconjugated ara-AMP and the conjugate were administered IM to woodchucks for 13 days. Unconjugated ara-AMP decreased viremia at the daily dose of 5 mg/kg but was ineffective at 2.5 mg/kg. The conjugate at the daily doses of 4.2 and 7 mg/kg (equal to 1.5 and 2.5 mg/kg of araAMP, respectively) markedly lowered the viremia, which decreased to undetectable levels in the animals treated with the higher dose. Assuming that in HBVinfected patients the same doses will be active, then the amount of conjugate (soluble at 200 mg/mL) required by a 70-kg patient will be contained in a volume of 1.5 to 2.5 mL, compatible with the IM route. Compared with a similar ara-AMP complex with lactosaminated human albumin, currently being studied in clinical trials for the treatment of chronic type B hepatitis, which must be infused intravenously, the present conjugate might provide more patient compliance because of IM administration.
Public Health Administration and the Natural History of Disease in Baltimore, Maryland, 1797-1920.
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction
Journal: Thorax (2017)

Corrections have been made to the 'Methods', 'Results' and 'Conclusions' section of this abstract.The changes are in bold. MethodsAn electronic search was performed to find patients on PCU whom received NIV between 1st January and 30th November 2014.Inclusion criteria were patients that had received NIV for COPD exacerbations solely.Data from the physician led respiratory unit between Jan-Nov 2011 was prospectively collected, and the two datasets compared. ResultsIn the respiratory unit 75 patients were admitted for NIV of which 39 met the criteria for inclusion in the analysis.In the PCU group 110 patients were admitted between Jan-Nov 2014 of which 55 were included for analysis.Samples were matched in gender, with no significant difference between groups.The average age of patients treated in PCU was 69.8 years, and 69 years on the respiratory unit (Mann-Whitney U Test, p=0.012).The in-hospital mortality on PCU was 27.2% compared to 15% on the respiratory unit ( p=0.15).Mean pH on PCU was 7.31 and 7.24 on the respiratory unit ( p=0.186, not significant).Mean pCO2 was lower at 9.16 kPa on PCU compared to 10.7 ( p=0.0703) on the respiratory unit, which is not statistically significant.Average length of stay was equal in both units at 12 days.Conclusions NIV delivered on a physician-led respiratory unit was not inferior in mortality and length of stay compared with a closed, ITU-led service in our hospital.Interestingly, the ward patients were sicker, with a lower mean pH and higher mean pCO2 but had a lower mortality, although not statistically significant.This supports a model where acute COPD patients needing NIV can be managed safely in a respiratory ward area with enhanced staffing as outlined in BTS guidelines.This could have continuity of care and cost benefits.
Food Poisoning from Alfalfa and Clover Sprouts
Journal: Annals of Internal Medicine (2001)

Summaries for Patients21 August 2001Food Poisoning from Alfalfa and Clover SproutsSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-135-4-200108210-00004 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Food poisoning is an illness that results from eating food contaminated with an infectious organism (bacteria, virus, parasite) or a toxin. More than 6 million cases of food poisoning occur every year in the United States. The most common symptoms of food poisoning are vomiting, diarrhea, and stomach pain. People usually recover quickly from food poisoning; some people, however, may need hospitalization and fluids to treat dehydration, and a few people die of food poisoning every year. A wide variety of foods can cause food poisoning if they ... Author, Article, and Disclosure InformationThe summary below is from the full report titled “Escherichia coli O157 and Salmonella Infections Associated with Sprouts in California, 1996–1998.” It is in the 21 August 2001 issue of Annals of Internal Medicine (volume 135, pages 239-247). The authors are JC Mohle-Boetani, JA Farrar, SB Werner, D Minassian, R Bryant, S Abbott, L Slutsker, and DJ Vugia, for the Investigation Team.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoEscherichia coli O157 and Salmonella Infections Associated with Sprouts in California, 1996–1998 Janet C. Mohle-Boetani , Jeff A. Farrar , S. Benson Werner , Dzovag Minassian , Ray Bryant , Sharon Abbott , Laurence Slutsker , and Duc J. Vugia , for the Investigation Team* Metrics 21 August 2001Volume 135, Issue 4Page: I-30KeywordsBacteriaDiarrheaEatingFood poisoningHospitalsNursing homesSalmonellaStomachToxinsVomiting ePublished: 21 August 2001 Issue Published: 21 August 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
MEDICAL DEPARTMENTS OF STATE UNIVERSITIES.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Human hepatic myofibroblasts increase invasiveness of hepatocellular carcinoma cells: Evidence for a role of hepatocyte growth factor
Authors: V Neaud, S Faouzi, J Guirouilh, B Le Bail, C Balabaud, P Bioulac-Sage, J Rosenbaum
Journal: Hepatology (1997)

The stroma of hepatocellular carcinomas (HCC) is infiltrated with myofibroblasts (MFs). Preliminary in vivo data have suggested that liver MF express hepatocyte growth factor (HGF), a cytokine that has been implicated in several tumor models. Our aim was to investigate the role of MF and HGF in HCC. Cultured liver MF expressed HGF messenger RNA (mRNA) and secreted HGF in their medium, as shown by Western blot, immunoprecipitation, and enzyme-linked immunosorbent assay (ELISA). Addition of MF-conditioned medium to the HepG2 HCC cell line induced cell scattering. This was associated with a decrease in cell proliferation. MF also increased about 100-fold the ability of HepG2 to invade Matrigel. Increased invasiveness was also shown for HuH7 cells, but no scattering was observed and cell proliferation was stimulated. All the effects of MF on both tumor cell types were blocked by addition of an antibody to HGF and they all could be reproduced by adding recombinant HGF to the tumor cells. RT-PCR and Western blot analysis confirmed that both tumor cell lines expressed c-met, the receptor for HGF. The effects of MF-conditioned medium were not reproduced by acidic fibroblast growth factor, basic fibroblast growth factor, epidermal growth factor (EGF), transforming growth factor-β1 (TGF-β1), or platelet-derived growth factor (PDGF-BB). Reverse transcription-polymerase chain reaction (RT-PCR) analysis confirmed that HGF was expressed in human HCC. Our data show that human liver MF act on HCC cells to increase their invasiveness and suggest that MF-derived HGF could be involved in the pathogenesis of HCC.