tbuckley/cabot-search huggingface dataset:
T Amer Acad Ophth Otolar, Rochester, Minn
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Metrizamide Cisternography
Authors: R. F. Heimburger
Journal: JAMA (1982)

<h3>To the Editor.—</h3> The exchange of opinions by Jahnke and Wesolowski (1982; 247:2779) regarding metrizamide cisternography in the diagnosis of the empty sella syndrome carries some important considerations. Medical literature reports many adverse reactions that include generalized and/or complex partial seizures, asterixis and encephalopathy, confusion, and speech disturbances as well as less disturbing reactions such as headaches, nausea, vomiting, and generalized malaise. Fortunately, the more serious complications are infrequent, occurring in less than one in 100 cases. Complications last up to 48 hours without recurrences. Metrizamide is a substantial advance in the radiological diagnosis of the nervous system. The incidence of complications is increased by increasing the total amount of metrizamide used. It should be noted that more metrizamide must be used to image the cerebral cisterns if it is introduced by the lumbar route rather than by the cervical route. More than 50 published reports of the intrathecal use
Commentaire de travail de T. Yano et al., pp. 717
Journal: Endoscopy (2008)

See also: Long-term results of salvage endoscopic mucosal resection in patients with local failure after definitive chemoradiotherapy for esophageal squamous cell carcinomaEndoscopy 2008; 40(09): 717-721DOI: 10.1055/s-2008-1077480
New evidence may expand indications for chemotherapy in breast cancer
Authors: B. Merz
Journal: JAMA (1989)

IT'S TIME TO RETHINK the role of chemotherapy in treating mammary carcinoma. That was the message delivered by Gianni Bonadonna, MD, in the 20th Karnofsky Award lecture at the annual meeting of the American Society of Clinical Oncology in San Francisco, Calif. Bonadonna, who is director, division of medical oncology, Istituto Nazionale Tumori, Milan, Italy, indicated that it may be time to go beyond current guidelines and employ combination chemotherapy as an adjuvant in some additional patient populations and as a primary therapy in others. The guidelines Bonadonna would like to expand were developed in response to the publication in December of a meta-analysis of 61 randomized trials that involved 28 896 women (<i>N Engl J Med</i>. 1988;319:1681-1692). All of the patients underwent surgical tumor resection with or without radiation. The study determined that mortality was lower in patients who also underwent subsequent drug therapy than in those who did
A comprehensive screening program for hemoglobinopathies
Authors: M. G. Barnes
Journal: JAMA (1972)

A comprehensive screening program for hemoglobinopathies, established in April 1970, includes a ten-minute cellulose acetate electrophoresis procedure for primary screening, additional laboratory studies for specific diagnosis, and clinical follow-up by neighborhood health center physicians. The simple screening test costs approximately 5 cents per sample and uses hemolysates prepared from packed unwashed red blood cells collected in microcapillary tubes. The electrophoresis procedure was easily learned by inexperienced volunteer technologists. During the first eight months, 107 of 1,000 health center patients and 63 of 358 hospital patients had hemoglobinopathies diagnosed. The basic screening method can distinguish sickle cell trait, sickle cell disease, and sickle cell-hemoglobin C disease. The comprehensive nature of the screening program is further demonstrated by the detection of patients with thalassemia minor, hereditary persistence of hemoglobin F, and hemoglobin types AC, CC, and B<sub>2</sub>.
Methods and Problems of Medical Education (Eight Series).
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
New Names
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The cardiac patient and general surgery
Authors: M. G. Perlroth
Journal: JAMA (1975)

THE PHYSICIAN called on to see a cardiac patient scheduled for general surgery should know what factors affect prognosis and what procedures will yield optimal care. <h3>Risks</h3> General anesthesia depresses myocardial function and often predisposes to arrhythmias. Although arterial Po<sub>2</sub>and Pco<sub>2</sub>may be adequately maintained during anesthesia, they may become abnormal temporarily during intubation and after extubation. Reflex adjustments to volume loss, position, and fever are depressed by anesthetics and narcotics. The risk of surgery is also a function of the duration and type of surgery. Operations in the thorax (non-cardiac) and on the great arteries have higher morbidity than surgery in the lower part of the abdomen and pelvis does. Obviously, hemorrhagic, pulmonary, thromboembolic, renal, and septic complications further tax any preexisting cardiac disability. Hemodynamic studies show that the cardiac index of patients surviving surgery usually rises and is maintained at elevated levels for several days postoperatively.
Should We Screen for Type 2 Diabetes?
Authors: David M. Rind
Journal: Annals of Internal Medicine (2017)

Letters4 April 2017Should We Screen for Type 2 Diabetes?David M. Rind, MDDavid M. Rind, MDFrom Beth Israel Deaconess Medical Center, Boston, Massachusetts.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L17-0026 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:I appreciate Mr. Petersen and Dr. Ratner's comments and am sorry to have caused outrage as well as, apparently, confusion. I was not referring to screening for overt diabetes (without quotation marks), a symptomatic disease that requires diagnosis. I also did not mean to suggest that no one should ever be screened for elevations in blood sugar that are too small to cause symptoms (what I defined as “diabetes”) but rather that the goal of such screening should focus on assessing global cardiovascular risk. Patients generally should not be tested if the results would not change treatment.Mr. ... Author, Article, and Disclosure InformationAffiliations: From Beth Israel Deaconess Medical Center, Boston, Massachusetts.Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M16-1091. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoShould We Screen for Type 2 Diabetes? Gerald W. Smetana , Martin J. Abrahamson , and David M. Rind Should We Screen for Type 2 Diabetes? Matthew P. Petersen and Robert E. Ratner Metrics 4 April 2017Volume 166, Issue 7Page: 535-536KeywordsBlood sugarCardiovascular disease riskConflicts of interestDisclosureRandomized trialsStatinsType 2 diabetes ePublished: 4 April 2017 Issue Published: 4 April 2017 Copyright & PermissionsCopyright © 2017 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
RESPIRATORY PITCH.
Authors: A. J. STEVENS
Journal: JAMA (1904)

Those who write their opinions on medical subjects, unsupported by reasons or experiments which can be put to the proof by any competent person, and those who write the "one consecutive case" articles may usually be considered bores. My justification for asking a hearing is based on something more definite than personal opinion, something which can be confirmed by evidence sufficient to prove a case in the courts. As a preliminary I will ask the reader's indulgence in the relation of a personal experience which may have a certain value to those interested in auscultation. Thirty-six years ago the teaching as to the pitch of respiratory sounds was the same as that of to-day. At that time it was my privilege to receive instruction in auscultation under a talented pupil of Dr. Austin Flint. Through personal experience of pulmonary disease my interest in becoming expert was great, but my first
Abstract 3621: Targeted hyaluronic acid nanoparticles improve treatment response in pancreatic cancer
Authors: Mohammad Raheel Jajja, Lei Zhu, Dazhi Wang, Charles A. Staley, Bassel El-Rayes, David A. Kooby, Lily Yang
Journal: Cancer Research (2019)

Abstract Pancreatic cancer has poor response to chemotherapy with desmoplastic stroma identified as a delivery barrier. We have developed a nanoparticle (NP) drug system using an engineered ligand of receptor binding region of urokinase plasminogen activator (ATF) and the catalytic domain of metalloprotease (MMP14) carrying SN38 (CPT-11 analog). Hyaluronic acid (HA), a naturally occurring protein was chosen as the backbone to produce a biocompatible NP. HA can also bind to CD44, highly expressed in epithelial cancers. Dual uPAR, CD44 targeting allows for targeted delivery and facilitates receptor mediated endocytosis of NP-drug complex. MMP14 activity degrades extracellular matrix to deplete the stromal barrier. SN38 was encapsulated and recombinant ATFmmp14 conjugated to surface of self-assembled hyaluronic acid spheres (200nm) to form the complete particle (HANP). Cytotoxicity assays were conducted to determine IC50 in cell lines. Patient derived xenograft (PDX) model of a drug resistant pancreatic cancer was used for efficacy studies. Orthotopically implanted tumors were treated with HANP (10mg/kg SN38 dosage) weekly for 6 weeks via tail vein and overall survival compared to conventional therapy. HANP in-vitro cytotoxicity was greater than conventional Irinotecan (&amp;gt;80x) and liposomal irinotecan (&amp;gt;900x) in a PDX derived cell line (Table 1). In-vivo efficacy study demonstrated a significant improvement in survival of PDX bearing mice with HANP (n=9) (median survival 50 days), compared to FOLFIRINOX (n=9) and Gemcitabine-nab-Paclitaxel (n=9) (median survival 37 days each) and no treatment (n=13) (median survival 22 days). Combination of HANP with a modified-FOLFIRINOX regimen (n=9) led to median survival &amp;gt;72 days (p&amp;lt;0.001). HANP alone or in combination with a modified FOLFIRINOX led to significantly improved survival in a pancreatic cancer PDX model. Further studies are underway to evaluate preclinical PD/PK for eventual translation as targeted therapy for pancreatic cancer. In-vitro cytoxicity assay for IC50 determinationDrugIC50 (uM)HANP0.01SN-380.012Irinotecan0.8Liposomal Irinotecan9 Citation Format: Mohammad Raheel Jajja, Lei Zhu, Dazhi Wang, Charles A. Staley, Bassel El-Rayes, David A. Kooby, Lily Yang. Targeted hyaluronic acid nanoparticles improve treatment response in pancreatic cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3621.
Standards and guidelines for cardiopulmonary resuscitation (CPR) and emergency cardiac care (ECC). Part VIII: Medicolegal considerations and recommendations
Journal: JAMA (1986)

These resuscitation guidelines were developed to "enhance the quality of care while protecting the patient's right to accept or reject therapy and to clarify the physician's role in making decisions to provide, withhold, or withdraw life support." Among the issues covered are the obligation to provide cardiopulmonary resuscitation (CPR), reasons to withhold or withdraw CPR, and the liability risks of CPR providers--laypersons, CPR teachers and organizations, and hospitals. Also discussed are the role of hospital ethics committees and medicolegal considerations in treating minors. The guidelines conclude with recommendations that states enact legislation allowing allied health personnel to render emergency care more effectively outside the hospital, providing "good samaritan" immunity to laypersons administering CPR, requiring basic life support training for police and firefighters, and acknowledging the patient's right to self determination in life-or-death decisions.
The Pill
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Authors’ reply: Outbreak of a new measles B3 variant in the Roma/Sinti population with transmission in the nosocomial setting, Italy, November 2015 to April 2016
Authors: Antonietta Filia, Marino Faccini, Antonella Amendola, Fabio Magurano
Journal: Eurosurveillance (2016)

Preview this article: Authors’ reply: Outbreak of a new measles B3 variant in the Roma/Sinti population with transmission in the nosocomial setting, Italy, November 2015 to April 2016, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/21/27/eurosurv-21-30276-6-1.gif
Abstract 20008: Echoing Plaque Activity of Coronary Artery With Intracranial Artery in Acute Ischemic Stroke Patients: Coronary CT Angiography and High-resolution MR Imaging Study
Authors: Jong-Won Chung, Jihoon Cha, Jin-Ho Choi, Yeon Hyeon Choe, Oh Young Bang
Journal: Circulation (2015)

Background: Atherosclerosis is a systemic disease, and both coronary and intracranial atherosclerosis are common in elderly. Unlikely to coronary artery disease (CAD), intracranial atherosclerotic disease (ICAD) can cause stroke by branch occlusive disease-type (B-type ICAS), subcortical infarcts caused by parent arterial disease occluding perforator’s orifice as well as coronary type rupture of plaque (C-type ICAS).Vascular pathophysiology of coronary atherosclerosis in relationship with different phenotypes of intracranial atherosclerosis is unknown. Methods: We prospectively recruited 69 patients with acute cerebral infarcts caused by ICAS who had no history of CAD. Patients underwent both cardiac multidetector computed tomography (MDTC) and brain high-resolution MRI (HR-MRI). Symptomatic steno-occlusive intracranial artery at the maximal stenosis on MRA was analyzed in terms of vascular morphology (stenosis degree, remodeling index, and wall index) and activation (enhancement pattern and volume) using HR-MRI. Asymptomatic CAD burden (number and degree of stenosis) and plaque characteristics (calcified, mixed, and non-calcified) were measured with MDCT. The degree of asymptomatic ICAD was also measured in each patient (number of stenotic arteries and degree of stenosis). Results: The mean age of the patients were 65.1±1.5 years, 59.4% were male, and 35 (51.7%) were diagnosed with C-type ICAS. Asymptomatic CAD was observed in most patients, and increase in CAD burden was associated with increased asymptomatic ICAD (p&lt;0.01). Overall CAD burden were not different between B-type and C-type ICAS. However, prevalence of non-calcified coronary plaque were much higher in C-type ICAS (35.3% vs 62.9%, p=0.02). C-type ICAS group also showed higher degree of stenosis (40.4 ±34.5 vs 77.3±17.3, p&lt;0.001), increased positive remodeling index (1.0±0.3 vs 1.3±0.5, p=0.03), and larger proportion of vessels with enhancement (73.5% vs 97.1%, p&lt;0.01) in cerebral arteries compared to B-type ICAS. Conclusions: Plaque characteristics of intracranial and coronary behave in same way. Further studies are needed to find systemic factors associated both intracranial and coronary plaque progression.
Erratum
Journal: Journal of Clinical Oncology (2018)

On page 285, the second sentence after the subheading Platelet Count at Which Surgical or Invasive Procedures May Be Performed, reads: "Certain procedures, such as bone marrow aspirations and biopsies, and insertion or removal of central venous catheters, can be performed safely at counts $ 20 X 10 9 /L."This sentence should have read: "Certain procedures, such as bone marrow aspirations and biopsies, and removal of central venous catheters, can be performed safely at counts < 20 X 10 9 /L."Also, on page 293, the 6 th line after the subheading Clinical Question 9, reads: "Certain procedures, such as bone marrow aspirations and biopsies, and insertion or removal of central venous catheters, can be performed safely at counts $ 20 3 10 9 /L."This sentence should have read: "Certain procedures, such as bone marrow aspirations and biopsies, and removal of central venous catheters, can be performed safely at counts < 20 X 10 9 /L."This has been corrected as of May 10, 2018.The authors apologize for the errors.
Masthead: (Adv. Healthcare Mater. 10/2018)
Journal: Advanced Healthcare Materials (2018)

Citizenship: Wiley's Corporate Citizenship initiative seeks to address the environmental, social, economic, and ethical challenges faced in our business and which are important to our diverse stakeholder groups.Since launching the initiative, we have focused on sharing our content with those in need, enhancing community philanthropy, reducing our carbon impact, creating global guidelines and best practices for paper use, establishing a vendor code of ethics, and engaging our colleagues and other stakeholders in our efforts.
441O Preliminary safety and clinical activity of erlotinib plus atezolizumab from a Phase Ib study in advanced NSCLC
Authors: B.B.Y. Ma, C.M. Rudin, A. Cervantes, A. Dowlati, D. Costa, P. Schmid, R. Heist, V.M. Villaflor, I. Sarkar, M.A. Huseni, P. Foster, C. O'Hear, S. Gettinger, B. Besse
Journal: Annals of Oncology (2016)
Research increasingly focuses on possible genetic factors in complex problem of alcohol abuse
Authors: T. F. Kirn
Journal: JAMA (1989)

THE NATIONAL Institute on Alcoholism and Alcohol Abuse (NIAAA) has put the call out for a long-term, multicenter study of families of alcoholics. The Rockville (Md)—based institute envisions the study as a collaborative effort among alcohol researchers, molecular biologists, and geneticists. Such a study may be the only way to answer some of alcoholism's enduring questions, particularly those centering on genetic aspects. Although there are some dissenters from mainstream opinion, the consensus is that alcoholism is a heritable disease with some basis in physiology. "The evidence is overwhelming," says Enoch Gordis, MD, director of the NIAAA. But, where observations have been made, the individual roles played by nature and by nurture have not been sorted out, and questions about which specific conditions are caused by alcohol abuse ("state") vs which are the cause of abuse ("trait") remain. <h3>Genetic Evidence Just Emerging</h3> Studies during this century have established that children in
A.N.A.
Authors: Peter H. Schur
Journal: New England Journal of Medicine (1970)

Antinuclear antibodies (ANA) are being used extensively for the study of patients with connective-tissue disorders. These autoantibodies probably result from a loss of self-tolerance due to exposure to foreign substances such as viruses, drugs or irradiation or on a genetic basis. The interaction between antigen and these antibodies can be measured by precipitation, diffusion in agar, binding assays, complement fixation or hemagglutination. Although only two nuclear antigens have been well defined — that is, deoxyribonucleic acid (DNA) and deoxyribonucleoprotein (DNA-histone) — the indirect immunofluorescent technic makes it clear that serums from patients with connective-tissue disorders contain antibodies to many nuclear . . .