tbuckley/cabot-search huggingface dataset:
Providers' concordance with survivorship clinical algorithms.
Authors: Frances Ann Zandstra, Guadalupe R. Palos, Ludivine Russell, Katherine Ramsey Gilmore, Jacklyn J. Flores, Delrose Ozeri, Maria Alma Rodriguez
Journal: Journal of Clinical Oncology (2014)

243 Background: The utility of algorithms to guide clinical practice related to long-term survivorship care is unclear. In 2012, lymphoma survivorship algorithms for Hodgkin’s and Large B-Cell were developed as part of an institutional clinical practice initiative to enhance survivors’ outcomes. Here we describe providers’ concordance with minimum standards recommended in the survivorship lymphoma algorithm. Methods: Concordance, the primary outcome, was defined as whether minimum recommendations, summarized in the lymphoma algorithms, were provided during a survivorship visit. Concordance was measured using a “yes/no” response format assessing whether a provider’s recommendations were consistent with algorithms’ minimum standards including: 1) physical examination, 2) laboratory and imaging testing, 3) cancer screening procedures, and 4) health promotion education. Data were abstracted from electronic medical records and Passports (summary care plans). Secondary outcomes were number of survivors seen and Passports issued. All data included in these analyses were de-identified. Results: 63 survivors were seen in the Lymphoma Survivorship Clinic from 05/01 to 09/30/2012 and all received Passports. A provider tailored the plan to each survivor’s needs and counseled the individual on disease surveillance, life-style changes, screening recommendations, and specific procedures to assess for recurrence/late treatment effects. Results indicated 100% of survivors received a physical exam, including cardiovascular screening. Similar rates were also achieved for CBC testing, chest X-rays, and counseling survivors on screening recommendations relevant to: breast, cervical, colorectal and prostate cancers. Other counseling rates included 97% for skin exam recommendations and 100% for maintaining adult vaccinations. Finally, providers’ concordance with assessment of survivors’ psychosocial distress was 100%. Conclusions: Based on concordance results, providers met the minimum recommendations listed in the lymphoma algorithms. Future research is needed to assess the impact of providers’ use of algorithms on survivors’ outcomes and feasibility of replicating concordance analyses in other clinical care settings.
Diabetes Control and Complications Trial (DCCT): Results of Feasibility Study. The DCCT Research Group
Journal: Diabetes Care (1987)

The Diabetes Control and Complications Trial (DCCT) is a multicenter, randomized, clinical study designed to determine whether an intensive treatment regimen directed at maintaining blood glucose concentrations as close to normal as possible will affect the appearance or progression of early vascular complications in patients with insulin-dependent diabetes mellitus (IDDM). We present the baseline characteristics and 1-yr results of the initial cohort of 278 subjects randomized in phase II of the trial, a phase designed to answer several feasibility questions before initiating a full-scale trial. During phase II, recruitment was completed on schedule. The 191 adults and 87 adolescents were randomized either to standard treatment (90 adults and 42 adolescents), designed to approximate conventional diabetes treatment, or to experimental treatment (101 adults and 45 adolescents), designed to achieve near-normal blood glucose and HbA1c concentrations. With few exceptions, baseline demographic, ophthalmologic, renal, and other medical characteristics were evenly distributed by randomization between the two treatment groups in both age strata. Glycemic control at baseline, as assessed by HbA1c concentrations and by blood glucose profiles, was comparable between the treatment groups in both age strata. The treatment strategies employed produced statistically significant and clinically meaningful differences in HbA1c concentrations and blood glucose profiles between the experimental- and standard-group subjects for both adults and adolescents. These differences were maintained throughout the feasibility phase. Except for an increased incidence of hypoglycemia in the experimental group, the two treatment regimens maintained or improved the clinical well-being of subjects in both groups. Adherence and completeness of follow-up were excellent (&amp;gt;95%), and the methods employed to measure biochemical and pathologic characteristics of IDDM proved to be reliable, reproducible, and precise. The feasibility phase of the DCCT demonstrated that a complex multicenter, randomized study of the relationship between diabetes control and complications can be performed. The full-scale, long-term trial therefore has been initiated.
Simple Gifts
Authors: M. THERESE SOUTHGATE
Journal: JAMA (1981)

TO DELIVER a convocation address is an occasion of grave temptation: for example, I am tempted to tell you everything I wish I had known when I was a freshman medical student. Worse even, I am tempted to tell you everything I think you should know, to wrap it, ribbon it, and present it to you in one neat little package that you can open from time to time and extract whatever sweet you may desire at the moment. But this would be a mistake. It would be, perhaps to save you a little pain, but it would also rob you of the greatest joy that comes from discovery. Certain things cannot be taught by telling—they must be experienced. And so I am not going to tell<i>you</i>anything. I am simply going to unwind a few threads from my own skein and let you weave them into the fabric
IONIZED CALCIUM IN THE BLOOD
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Predicting coronary heart disease in middle-aged and older persons. The Framington study
Authors: T. Gordon
Journal: JAMA (1977)

Of 1,025 men and 1,445 women, aged 49 to 82 years, who were free of coronary heart disease (CHD), 79 men and 63 women subsequently had CHD. Using a risk function based on cholesterol in the high density and low density lipoproteins, systolic blood pressure, left ventricular hypertrophy, and diabetes, less than 2% of the subsequent CHD cases were found in the lowest decile of risk, whereas 25% of the cases for men and 37% for women were found in the highest decile. Predictability held for each specific age group. This predictability was at least as good as that obtained by the usual CHD risk profile at younger ages. (<i>JAMA</i>238:497-499, 1977)
Editorial: Drugs for prevention of malaria.
Journal: BMJ (1974)

include impairment of urine concentrating or acidifying ability.The lesions may affect the medulla and cortex,19 and though cortical and medullary necrosis may be found post mortem without vascular lesions, some cases of both venous and arterial thrombosis are accompanied by extensive tissue necrosis.5Children who recover from cortical necrosis may develop renal insufficiency, tubular lesions, and hypertension.There is, then, a spectrum of vascular lesions of similar causation; these may result in similar late effects.Careful clinical assessment, specialized radiological techniques, and in many cases renal biopsy will be needed if prognosis and treatment are to be properly determined.
Highlights from this issue
Authors: Gisli Jenkins, Nicholas Hart, Alan Smyth
Journal: Thorax (2015)

In this edition of the journal, we publish four papers that are being presented at a special session of the BTS winter meeting, highlighting the excellence of the work published in Thorax.These papers cover tuberculosis, chronic obstructive pulmonary disease and interstitial lung disease, with both basic science and clinical research represented.In this month's airwaves we give you a taster of this session and much, much more… "…YOUTH GROWS PALE, AND SPECTRE-THIN, AND DIES…"
Incorrect State Listed
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reminder
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Top-line results from SUNRISE: A phase III, randomized, double-blind, placebo-controlled multicenter trial of bavituximab plus docetaxel in patients with previously treated stage IIIb/iv non-squamous non-small cell lung cancer
Authors: D.R. Spigel, I. Bondarenko, G. Losonczy, J. Mezger, H. Kalofonos, M. Reck, R. Palmero, T. Jang, R. Natale, R.E. Sanborn, J. Lai, N. Kallinteris, M. Tang, J. Shan, D. Gerber
Journal: Annals of Oncology (2016)
Abstract 2999: Hybrid complex between bispecific peptide and antibody for targeted cancer therapy
Authors: Byeongjun Yu, Dobeen Hwang, Sangyong Jon, Junho Chung
Journal: Cancer Research (2019)

Abstract Antibodies have been used for cancer therapy for two decades, but they suffer from poor localization and penetration into solid tumors because of their large size. Peptides can be an alternative for treatment of solid tumors due to their small size. However, therapeutic use of peptides is limited because of their short plasma half-life. We present a new molecular platform based on a hybrid complex between bispecific peptide and antibody, designated as HyPEP-body, composed of bispecific peptides labeled with a hapten as a pharmacophore and an anti-hapten antibody. Two different peptides are joined together with linker and then, labeled with the hapten. The bispecific pharmacophore are bound to the anti-hapten antibody through antigen-antibody interaction. The pharmacophores which can be chemically optimized or replaced with other peptides are in charge of therapeutic function, while the antibody imparts long plasma half-life. As a model study, we constructed HyPEP-body that simultaneously binds extra domain B (EDB) and vascular endothelial growth factor (VEGF) with EDB binding peptide, VEGF binding peptide, cotinine and anti-cotinine antibody. Complexation with the antibody extended the plasma half-life of the bispecific pharmacophores. Furthermore, bispecific pharmacophores released from the antibodies distributed more widely in the tumor tissue than the antibodies. Finally, treatment of the HyPEP-body inhibited tumor growth in U87MG, human glioblastoma, xenograft mouse model. This versatile hybrid platform will enhance the value of peptide therapeutics and suggest an innovative solution to the development of bispecific antibodies that has suffered from productivity issues. Citation Format: Byeongjun Yu, Dobeen Hwang, Sangyong Jon, Junho Chung. Hybrid complex between bispecific peptide and antibody for targeted cancer therapy [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2999.
Comparison of Proliferating Cell Nuclear Antigen to Tritiated Thymidine As a Marker of Proliferating Hepatocytes in Rats
Authors: Julie Foley, Thai Ton, Robert Maronpot, Byron Butterworth, Thomas L. Goldsworthy
Journal: Environmental Health Perspectives (1993)

Proliferating cell nuclear antigen (PCNA), an endogenous nuclear protein, has recently been used to identify replicating cells.PCNA was compared to tritiated thymidine ([3Hl-TdR), a reli- able and accurate exogenous labeling agent, to ascertain if PCNA gives comparable results for quantitative cell proliferation.Male F344 rats were treated with a single dose of 500 mg/kg 4-acetylaminofluorene (4-AAF), a known liver mitogen.Rats (n = 5) were euthanized and necropsied at 6, 12, 18, 24, 36, 48, 96, or 192 hr after treatment.Two hours before necropsy, rats were pulse-dosed with [3H]-TdR (2 mCi/kg body weight).Livers were sectioned, autoradiogra- phy performed, and labeling indexes (LI), a measurement of the percentage of S-phase hepato- cytes, determined.One and a half years after the completion of this study, the archival paraffin blocks of the liver tissue were sectioned and stained for PCNA by an immunohistochemical pro- cedure.Immunocytochemical staining patterns of proliferating cell nuclear antigen expression permitted the recognition of G,, S, G2, M, and quiescent cells.PCNA LI, generated by scoring only cells exhibiting S-phase staining patterns, was compared to the pulse [3H]-TdR LI for each animal.Similar periportal staining patterns of S-phase nuclei were detected by both markers.The [3H]-TdR LI and the PCNA LI exhibited a peak at 24 hr of approximately the same magni- tude.However, while the [3H]-TdR LI had returned to near baseline at the 48-hr time point, the PCNA LI remained elevated until the 96-hr time point.This sustained elevation of the PCNA index cannot be explained at this time.Examination of all other time points revealed similar S- phase LI by either method.PCNA immunostaining allowed for the estimation of the growth fraction.A time-dependent alteration in the hepatic growth fraction curve was a consequence of 4-AAF treatment.
Editorial: Amyloid arthropathy.
Journal: BMJ (1974)

Mental Side Effects of PentazocineAs clinical experience of the use of pentazocine has accumu- lated occasional unpleasant nalorphine-like perceptive effects have been reported, particularly after parenteral administration.1-3These include visual and auditory hallucinations, dreams, delusions, euphoria, dysphoria, feelings of depersonalization, panic, and abnormal thoughts.Further evidence for the occurrence of central nervous system disturbances now comes from a prospective open study reported this week by the Medicines Evaluation and Monitoring Group (p.305).However, the incidence of such reactions in hospital patients receiving other analgesic drugs is unknown, and prospective double-blind studies with patients matched for age, associated disease, and dose of drug are ideally needed for accurate evaluation of the frequency of these perceptual disturbances.One aspect of the problem of adverse drug reactions re- emphasized by the study is the low level ofvoluntary reporting -only 1 of the 18 cases detected had been reported to the Committee on Safety of Medicines.The current preparation ofpentazocine is a racemic mixture, and both its analgesic and common adverse actions have been attributed to the laevo isomer,4 whereas the psychotomimetic effects may be associated with the dextro form.5The principal unwanted effects are sedation, sweating, dizziness, and light- headedness.Nausea may occur, but vomiting is less frequent than after the administration of morphine.As with all narcotic drugs, caution is required when prescribing for patients with respiratory insufficiency, head injury, or convulsive states.In patients with hypertension caution is required as the blood
Urinary tract infection due to Actinobacillus actinomycetemcomitans
Authors: T. R. Townsend
Journal: JAMA (1969)

<h3>To the Editor:—</h3> I was shocked at a recent picture of firemen sawing a hole to free a child's finger, stuck in a lug hole of an auto wheel. It took an hour, when the finger could have been freed painlessly in a couple of minutes by the same method I use to remove a ring from a swollen finger. I have used the method for some 40 years, can't remember where I learned it, and thought it was generally known. Apparently it isn't, and it should be. It is usually possible to pass a string through the ring. The string is then wound tightly around the swollen side, making a half-dozen turns next to the ring. It is then un-wound from the other side while exerting tension on the string. (Figure). This is continued until the ring is free.
HYPOGLYCEMIA AND CONVULSIONS
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Autophagy Inhibition Potentiates Ruxolitinib-Induced Apoptosis in JAK2V617F Cells
Authors: João Agostinho Machado-Neto, Juan Luiz Coelho-Silva, Fábio Pires de Souza Santos, Priscila Santos Scheucher, Paulo Vidal Campregher, Nelson Hamerschlak, Eduardo Magalhães Rego, Fabiola Traina
Journal: Blood (2018)
Standard Clotting Time, A Method Using Venous Blood in Capillary Tubes
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
One in eight GP training posts vacant, despite unprecedented third round of recruitment
Authors: Abi Rimmer
Journal: BMJ (2014)

Chapter Two -What will the future look like?A new relationship with patients and communities…..page 10 -Getting serious about prevention…..page 10 -Empowering patients…..page 13 -Engaging communities…..page 14 -The NHS as a social movement…..page 15Chapter Three -What will the future look like?New models of care…..page 17 -Emerging models…..page 17 -One size fits all?.....page 18 -New care models….page20 -How we will support local co-design and implementation…..page 26Chapter Four -How can we get there?.....page 29 -We will back diverse solutions and local leadership…..page 29 -We will create aligned national NHS leadership…..page 29 -We will support a modern workforce…..page 30 -We will exploit the information revolution…..page 32 -We will accelerate useful health innovation…..
The 20th Year of AIDS: A Time to Re-Energize Prevention
Journal: JAMA (2001)

Since the first acquired immunodeficiency syndrome (AIDS) cases were reported in 1981, human immunodeficiency virus (HIV) has caused approximately 22 million deaths worldwide. In the United States, approximately 400,000 persons have died, and approximately one million have been infected. However, numerous persons have avoided infection through prevention efforts, and many lives have been prolonged through advances in treatment.
检测原位黑色素瘤的算法
Authors: S. Borsari, R. Pampena, E. Benati, C. Bombonato, K. Athanassios, E. Moscarella, A. Lallas, G. Argenziano, G. Pellacani, C. Longo
Journal: British Journal of Dermatology (2018)

原位黑色素瘤(MIS)是被称为黑色素瘤的皮肤肿瘤的极早期阶段。近几十年来,黑色素瘤的发病率以每年2.6% 的速度增长,而MIS是造成这一增长的主要诊断物。识别MIS非常重要,因为在这一阶段(被称为表皮内阶段),癌细胞没有机会扩散到体内任何部位。由于从良性(无害)色素病变(比如正常胎块)中区分MIS非常具有挑战性,因此意大利雷焦艾米利亚的研究人员开展了本研究,考虑通过两种无创(即无需任何手术)方式来诊断皮肤癌,分别被称为反射共焦显微镜(RCM)和皮肤镜,看看能否利用它们来检测表皮内黑色素瘤。皮肤镜是一种价格低廉的方法,已在全球范围内应用20年之久:医生会使用一种被称为皮血管镜的手持设备来观察放大十倍左右的皮肤,以观看肉眼无法看到的东西。RCM是最近兴起的一种技术,但不太容易获得,可创建某部分皮肤的灰度等级图像,让医生在放大500倍左右的情况下观察异常。作者使用皮肤镜和RCM分析了120个MIS和213个痣(胎块),以识别与MIS诊断相关的一些特征(表皮内黑色素瘤的RCM形态尚不清楚)。然后在一个多步诊断算法中结合这些特征,这能够帮助医生决定给定的色素病变是否是早期黑色素瘤(评分≥2则意味着黑色素瘤),误差非常小。这种新型诊断算法易于应用,可能有助于医生诊疗。