tbuckley/cabot-search huggingface dataset:
Listing Sources of Pain Control
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
In This Issue
Journal: Arthritis & Rheumatology (2016)

Myeloid-Derived Cell Types May Play Role in Pathology of Lupus Apoptotic cell-derived, proinflammatory circulating microparticles have been identified in patients with systemic lupus erythematosus (SLE).The microparticles stimulate plasmacytoid dendritic cells (PDCs) and myeloid dendritic cells (MDCs).They also enhance the production of neutrophil extracellular traps (NETs) during NETosis.In this issue, Dieker et al (p.462) report on a study in which they determined the characteristics of circulating microparticles in patients with SLE and assessed the impact of these microparticles on the immune response.Researchers found that microparticles in patients with SLE were highly positive for annexin V and apoptosis-modified chromatin, unlike the microparticles found in patients with rheumatoid arthritis (RA), patients with systemic sclerosis (SSc), or healthy controls.Additionally, the microparticles from patients with SLE were negative for B and T cell markers but positive for endothelial and granulocyte markers.The microparticles from patients with SLE increased expression of the costimulatory surface molecules CD40, CD80, CD83, and CD86 and production of the proinflammatory cytokines interleukin-6 (IL-6), tumor necrosis factor, and interferon-α (IFNα) by stimulated PDCs and MDCs.The microparticles also primed bloodderived neutrophils for NETosis.
Factors Influencing Blood Pressure
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
UW-preservation of cultured human gallbladder epithelial cells: Phenotypic alterations and differential mucin gene expression in the presence of bile*1
Authors: J CAMPION
Journal: Hepatology (1995)

In orthotopic liver transplantation, extended cold ischemia of the graft may induce cell damage, particularly in biliary epithelium. We have investigated the effects of a cold University of Wisconsin (UW) solution on cultured human gallbladder biliary epithelial cells (GBEC) exposed or not exposed to stagnant bile. In UW solution, morphological alterations of cultured GBEC were not prominent under light microscopy after 16 hours at 4°C, being more striking after 24 to 48 hours. Ultrastructural examination of GBEC showed a condensation of chromatin at the periphery of the nuclei after 16 hours in cold UW solution. Both protein and DNA syntheses were strikingly reduced in these cells. After rewarming in standard Williams' medium at 37°C for 24 hours, cultured GBEC exhibited both normal morphology and function. As in both freshly isolated and routinely cultured GBEC, rewarmed cells expressed various mucin genes, namely MUC1, MUC3, MUC4, MUC5AC, and MUC5B genes, whereas MUC2 mRNAs were barely detectable. Adramatic decline in the steady-state mRNA levels of both MUC3 and MUC5B was found in cultured GBEC versus freshly isolated cells. Addition of bile into UW solution at 4°C had no significant effect on GBEC morphology and DNA and protein syntheses. When bile was added during the rewarming period, both protein and DNA syntheses were strongly reduced. Addition of bile during either storage in UW solution or rewarming period induced increased steady-state MUC2, MUC3 and MUC5AC mRNA levels. These results show that UW is a reliable cold storage solution for GBEC and the presence of stagnant bile within the culture medium during the rewarming period leads to deleterious phenotypic alterations of these cells. This suggests changes in the management of liver graft during orthotopic liver transplantation.
Deconstructing empathy
Authors: John N. Constantino
Journal: Behavioral and Brain Sciences (2002)

Under Preston &amp; de Waal's proposed model, empathy might be regarded as everything that determines the quality of a social relationship. Although the authors provide a useful heuristic for understanding relationships, clinical research efforts with a somewhat narrower focus have provided some additional insights into this topic, which might lead to testable hypotheses regarding the neurobiology of empathy.
The 'supply side' economics of sodium metabolism
Authors: F. H. Shen
Journal: JAMA (1981)

THESE days, while the economy is the hot topic and David Stockman the rising star, I find it difficult to concentrate on medical grand rounds. The usual sense of guilt over not being fully devoted to medicine lingers. That is, until a visiting professor at a recent grand rounds began his elaborate discussion on the "forward" vs "backward" hypotheses of ascites formation. Then, eureka! It came to me, the realization that economy and medicine do mix, that the case presented of advanced liver cirrhosis with refractory ascites is indeed a metaphor for our national economic problems. Economics is a profession in double jeopardy: on the one hand, the accuracy in predicting future trends often is no better than the weatherman's forecast. On the other hand, the economist, like the physician, is burdened by opposing hypotheses. There are at least two reasons why such opposing views coexist in economics and medicine.
Epidemic Trichophyton mentagrophytes infections in servicemen. Source of infection, role of environment, host factors, and susceptibility
Authors: A. M. Allen
Journal: JAMA (1973)

Epidemic inflammatory dermatophytosis among US combat forces in Vietnam was caused by a pancreatopeptidase E-producing, small (a) mating type, zoophilic variety of<i>Trichophyton mentagrophytes</i>,a variety not ordinarily isolated in the United States. An abundant reservoir of zoophilic<i>T mentagrophytes</i>was discovered in commensal rats; carriage was frequent on normal-appearing perineal skin. Variations in prevalence and severity of infection were related to differences in clothing, wet terrain exposures, and duration of tropical service. Our findings suggest that (1) T mentagrophytes infections were acquired in Vietnam, possibly from rats; (2) risk of infection was directly related to degree of exposure to wet clothing; (3) Americans were distinctly more susceptible to T mentagrophytes infections than were adult Vietnamese.
Correction
Journal: BMJ (1960)

Any Questions ?We publish be-low a selection of those questions and answers which seem of general interest.It is regretted that it is not possible to supply answers to all questions submitted.Coronary Arterial Spasm Q.-Is there such a thing as coronary arterial spasm ?How can it be diagnosed and treated ?A.-Patients with recurrent and typical cardiac pain on effort or at rest for many years, associated with a good prognosis, have been diagnosed as having coronary arterial spasm.The cardiogram in these patients showed minor changes in the S-T T wave, or marked and widespread inversion of the T wave which reverted to normal after an interval.The pain and acute cardiographic changes were considered to be due to cardiac ischaemia resulting from spasm of the left coronary artery distal to the circumflex branch and proximal to the left marginal branch, the artery being unaffected by occlusive sclerosis.'
Completeness of toxicological analyses
Authors: P. Goldman
Journal: JAMA (1980)

<h3>In Reply.—</h3> Anaphylaxis and anaphylactoid terms have been variably used in the medical literature. Classic anaphylaxis is an immediate systemic reaction, IgE mediated and clinically occurring as cardiocirculatory collapse, urticaria, bronchospasm, and laryngospasm, usually leading to death unless treated promptly. Such an occurrence in various degrees of severity is not uncommon in the Allergy Clinic, where desensitization to various allergies are done. Similar anaphylaxis type of reactions, both fatal and nonfatal, have been reported after iodinated contrast material,<sup>1</sup>and the vast majority of those reported are so mild as to require no therapy (231:974, 1975). The basic hypothesis seems to be either IgE medicated antigen-antibody reactions, nonspecific histamine releasing mechanisms, or nonspecific complement activation resulting in mast cell degranulation and histamine release. This hypothesis has not been fully tested, and results have been inconclusive. There are many substances of different nature and biochemistry that have also been known to
Egg-Yolk and Serum Cholesterol Levels: Importance of Dietary Cholesterol Intake
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Myocardial Infarction Associated With Antihypertensive Drug Therapy
Authors: W. E. Feeman
Journal: JAMA (1996)

<h3>To the Editor.</h3> —The study by Dr Psaty and colleagues<sup>1</sup>is simply a lesson in what happens when one does not learn from failures of the past. In brief, Psaty and colleagues reviewed charts of hypertensive patients in the Group Health Cooperative (GHC) of Puget Sound in Washington States, a plan that appears to be a health maintenance organization that controls the medications dispensed by its pharmaceutical outlets. As a result, long after immediate-release calcium channel blockers (CCBs) became irrelevant to mainstream medical practice, some patients continued to receive them in preference to sustained-release CCBs, which probably, at least in part, was due to cost-containment measures. As was the standard of practice during the study period, GHC physicians prescribed CCBs for patients with complicated hypertension, such as those with atherosclerotic heart disease (ASHD). This is borne out by the increased prevalence of ASHD in patients who have been prescribed
Abstract 462: Results from multiple datasets including the TCGA reveal limited clinical significance of molecular subtypes in bladder cancer
Authors: Sarrah S. Lahorewala, Daley S. Morera, Jiaojiao Wang, Vinata B. Lokeshwar
Journal: Cancer Research (2019)

Abstract INTRODUCTION AND OBJECTIVE: Molecular subtypes have been suggested to predict outcome in patients with muscle invasive bladder cancer (MIBC). The major subtypes reported have been “luminal” and “basal”; however, there is little consensus regarding subtype-signatures and the clinical parameters used to evaluate outcome. The objective of this study was to examine using multiple datasets, if molecular subtypes are distinct entities within MIBC and whether they predict clinical outcome. METHODS: We analyzed transcriptome data from all 402 MIBC samples in The Cancer Genome Atlas (TCGA) and 151 high-grade MIBC samples from three datasets in Oncomine™. Transcript levels were also measured in 52 bladder tumor specimens with clinical follow-up (cohort-1). Samples were subtype-scored using gene panels (GP-11, GP-30, BASQ) consisting only of those genes common among published studies. Correlation of subtypes to recurrence/progression-free survival (R/PFS), metastasis, cancer-specific survival (CSS) and overall-survival (OS) was examined by logistic regression, Cox proportional Hazards model and Kaplan-Meier analyses. RESULTS: Based on GP-11 subtype-scoring, &amp;gt;75% of the MIBC TCGA-dataset samples were mixed, i.e. neither pure-luminal nor pure-basal. When tumors were categorized as pure-luminal, pure-basal, or mixed, the subtypes could not predict OS or R/PFS. Consistent with published studies, when tumors were categorized as luminal or basal the subtypes predicted OS (P=0.051); sensitivity: 53.9%; specificity: 62%. Subtypes also correlated with tumor-grade (P=0.0005); most low-grade MIBC cases (16/21) in the TCGA-dataset were luminal. However, MIBC is rarely low-grade and subtypes could not predict OS (P=0.131) when only high-grade cases were included. Subtypes were not significant prognosticators in multivariate analyses. GP-30 and BASQ panels validated these results. In the Oncomine-dataset and cohort-1, subtypes could not predict metastasis, CSS, or OS. CONCULUSIONS: Our study of multiple datasets reveals that molecular subtypes may reflect tumor-heterogeneity but are likely not distinct entities within MIBC. Furthermore, molecular subtypes have limited prognostic capability for MIBC patients. Although there is a need to individualize patient care, further examination into the molecular subtypes of MIBC is needed before their incorporation into clinical practice. Citation Format: Sarrah S. Lahorewala, Daley S. Morera, Jiaojiao Wang, Vinata B. Lokeshwar. Results from multiple datasets including the TCGA reveal limited clinical significance of molecular subtypes in bladder cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 462.
Unsuccessful treatment of staphylococcal endocarditis with cefazolin
Authors: R. E. Bryant
Journal: JAMA (1977)

Two patients with staphylococcal endocarditis were treated unsuccessfully with cefazolin sodium. One patient relapsed after 52 days of therapy. The second patient had concomitant central nervous system infection and failed to respond to cefazolin therapy. Both patients recovered with methicillin sodium or nafcillin sodium therapy. Other studies report unsuccessful therapy of staphylococcal endocarditis with cefazolin. (<i>JAMA</i>237:569-570, 1977)
Epitomies
Journal: JAMA (1975)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Wrong Janssens
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Croonian Lectures: A Contribution to the Study of the Blood and the Circulation: Delivered before the Royal College of Physicians of London
Authors: G. Oliver
Journal: BMJ (1896)

ANIMAL EXTRACTS. -SOME preliminary observations with the arteriometer having afforded me evidence that certain of the animal extracts (such as those of the suprarenal bodies, the thyroid gland, and the brain tissue), when administered to healthy subjects suprarenal.X1 he 1 esults of this research have appeared in the Jouirnal of Phypiology,
Questions and Answers
Journal: JAMA (1978)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Potential Hazards of Fumigant Residues
Authors: Lawrence Fishbein
Journal: Environmental Health Perspectives (1976)

A spectrum of fumigants (primarily ethylene dibromide, 1,2-dibromo-3-chloropropane, ethylene oxide, symdibromotetetrachloroethane, 1,3-dichloropropene, dichlorovos, carbon tetrachloride, methyl bromide) as well as their degradation products in foodstuffs and soil have been examined mainly in regard to the potential mutagenicity of their residues.
Wrong Authors in Table of Contents.—
Journal: JAMA (1975)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal