tbuckley/cabot-search huggingface dataset:
Arsenical Encephalopathy
Authors: G. W. Csonka
Journal: BMJ (1947)

and also in primary suppurative meningitis due to the pneumo- coccus and nmany due to H. influenzae (Pfeiffer) is not ques- tioned, but in meningococcal cases its superiority to oral and systemic sulphonamides has not been established, and its use is attended with unjustifiable risks.-Iam, etc.,
Making the family history relevant
Authors: R. C. Juberg
Journal: JAMA (1972)

Though there are several reasons for including family data in a medical history, such information often turns out to be irrelevant. Still, family information may be made relevant by recording certain minimal data about first-degree relatives; by asking five questions designed to survey the family for occurrence of the same problem, related problems, clearly heritable traits, unusual conditions, and consanguinity; and by contructing a pedigree. The first step applies to every history; the second step to most; the third to only a few.
Substructural QSAR Approaches and Topological Pharmacophores
Authors: Rainer Franke, Stefan Huebel, W. Juergen Streich
Journal: Environmental Health Perspectives (1985)

For large and diverse data sets, simple QSAR methods based on linear and additive models can no longer be applied. In such cases topological methods using descriptors directly derivable from two-dimensional chemical structures provide a useful alternative. The results of such analyses can be used for lead optimization, to guide biological testing and even aid in the design of novel compounds. Various types of topological descriptors and algorithms are briefly discussed. Which of those is to be selected depends on the objective of the investigation and the properties of the data set. Two new methods, LOGANA and LOCON, are discussed in some more detail. With the help of these methods, substructural patterns ("topological pharmacophores") characteristic of compounds possessing a certain biological property can be evaluated. Both methods are designed in such a way that full use can be made of the data handling capacity of computers while maintaining an optimal impact of the experience of the researcher. They are model-free and do not require any mathematical knowledge. While LOGANA deals with semiquantitative or even qualitative biological data, LOCON can be applied to activity data on a continuous scale. The basic procedure in both cases consists in the stepwise combination of substructural descriptors by the logical operations "and," "or" and "not." With a simple example the utility of the methods is demonstrated.
Overexpression of the serpin megsin induces progressive mesangial cell proliferation and expansion
Authors: Toshio Miyata, Reiko Inagi, Masaomi Nangaku, Toshiyuki Imasawa, Masahiro Sato, Yuko Izuhara, Daisuke Suzuki, Atsusi Yoshino, Hiroshi Onogi, Minoru Kimura, Satoshi Sugiyama, Kiyoshi Kurokawa
Journal: Journal of Clinical Investigation (2002)

Mesangial cells maintain normal glomerular function by mediating ECM remodeling and immune complex disposal. We have recently identified megsin, a novel member of the serine protease inhibitor (serpin) superfamily predominantly expressed in the mesangium. While our previous studies suggested a role for megsin in the pathogenesis of human glomerular diseases, its exact biological significance remained unknown. Here we produced two lines of megsin transgenic mice. Overexpression of megsin led to progressive mesangial matrix expansion and an increase in the number of mesangial cells. These glomerular lesions were accompanied by an augmented immune complex deposition, together with Ig’s and complement. Binding and functional assays in vitro identified plasmin as one biological substrate of megsin and confirmed its activity as a proteinase inhibitor. Transgenic animals exhibiting nephritis as a result of treatment with anti–glomerular basement membrane antiserum showed significantly more persistent expansion of the mesangial ECM than was seen in parental mice. Megsin therefore exerts a biologically relevant influence on mesangial function, and on the mesangial microenvironment, such that simple overexpression of this endogenous serpin engenders elementary mesangial lesions.
Radiographic Changes in Renal-Vein Thrombosis
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
<i>Diseases of the Lungs, Heart, and Kidneys.</i>By N. S. Davis, Jr., A. M., M. D., Professor of Principles and Practice of Medicine, Chicago Medical College. No. 14 in the Physicians' and Students' Ready Reference Series. l2mo., 359 pages, Extra Cloth, $1.25 net. Philadelphia: The F. A. Davis Co., 1231 Filbert Street
Authors: R. R. D.
Journal: American Journal of Psychiatry (1893)
Electromagnetic pulse and its effects. Board of Trustees, American Medical Association
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cat-bite tularemia
Authors: R. W. Quenzer
Journal: JAMA (1977)

TULAREMIA is remarkable for its diverse modes of transmission and variable forms of presentation in humans. Although rabbits and ticks have been the main sources for sporadic cases of human tularemia throughout the United States, more than 100 different animals may transmit the disease. This case is of interest because of the unusual source of the infection. <h3>Report of a Case</h3> On Sept 23, 1976, a 33-year-old surveyor was bitten on the right hand by an 8-week-old domestic kitten that had been raised on his ranch in southwestern Colorado. Four days later, he was admitted to a hospital in Durango, Colo, because of fever, chills, swelling of his right hand, and pain in his right axilla. He had an oral temperature of 38.5 °C, a clean ulcerated wound near the metacarpophalangeal joint of the right index finger, and a tender, enlarged, right axillary lymph node. A WBC count was 9,500/cu
Inner-city asthma control campaign under way
Authors: C. Marwick
Journal: JAMA (1995)

THE NATIONAL Medical Association (NMA) is making a major effort to combat asthma in the areas and populations where the disease has its greatest impact—minority groups in the inner city. For several years, alarmed by increasing morbidity and mortality from asthma, government and private groups have been sounding warnings, urging that the problem receive wider attention. For example, the situation prompted the National Heart, Lung, and Blood Institute (NHLBI) at the National Institutes of Health to issue in January 1991 a complete set of guidelines for the diagnosis and management of asthma. In 1993, a 15-member coalition of physicians, nurses, and representatives from lay groups called the Asthma Zero Mortality Coalition, was formed to address the problem of asthma morbidity and mortality and to publicize and distribute educational materials. Its goal is to reduce deaths from asthma to zero by the year 2000. Last year, the Asthma Coalition began a
TM6SF2/PNPLA3/MBOAT7 loss-of function genetic variants impact on NAFLD development and progression both in patients and in in vitro models
Authors: Miriam Longo, Marica Meroni, Veronica Erconi, Anna Alisi, Luca Miele, Raffaela Rametta, Anna Ludovica Fracanzani, Luca Valenti, Paola Dongiovanni
Journal: Journal of Hepatology (2020)
Ultrasound as an aid in the diagnosis of hydrops of the gallbladder
Authors: P. C. Chandnani
Journal: JAMA (1977)

ACUTE cholecystitis and acute hydrops of the gallbladder present as a surgical emergency. Ultrasonography provides a simple, rapid, and noninvasive procedure, which is helpful in the evaluation and diagnosis of gallbladder disease. A case of acute hydrops of the gallbladder in which cholecystosonography was helpful in its management is presented. <h3>Report of a Case</h3> A 96-year-old woman was admitted for abdominal pain of one day's duration. The patient experienced crampy abdominal pain in the right upper quadrant but denied nausea or vomiting, alteration in bowel habits, or change in color of stool or urine. The patient had no jaundice, abdominal distention, or fever. She gave a history suggesting mild cholecystitis for 55 years. Tenderness was present in the right upper quadrant and the right costovertebral angle. A complete blood count showed leukocytosis with shift to the left. Hematocrit reading was 40%, and hemoglobin level was 10 gm/100 ml. The patient
The Principles and Practice of Hydrotherapy. A Guide to the Application of Water in Disease. For Students and Practitioners of Medicine.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Miscellanea Medica
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Side effects of various Hodgkin's therapies
Journal: JAMA (1981)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Oncology Research Program
Authors: Paul Chapman
Journal: Journal of the National Comprehensive Cancer Network (2014)

The goal of the Highlights of the NCCN Oncology Research Program (ORP) is to provide readers with more information on the ORP, including studies currently accruing patients.For more information on specific trials, including patient selection criteria, please use the contact information listed with each study.For more information on the NCCN ORP, including a complete detailing of the clinical studies currently underway at NCCN Member Institutions, please access the NCCN ORP pages at NCCN.org/clinical_trials/ clinicians.asp. Highlights of the NCCN Oncology Research ProgramThe NCCN Oncology Research Program (ORP) strives to improve the quality of life for patients and reduce cancer-related deaths by advancing cancer therapies through research.Since the program's establishment in 1999, the NCCN ORP has brought millions of dollars in research grants to investigators at NCCN Member Institutions.Research grants are provided to NCCN through collaborations with pharmaceutical and biotechnology companies; these grants are in turn used to support scientifically meritorious cancer research efforts.NCCN ORP studies typically explore new avenues of clinical investigation and seek answers to important cancer-related questions.All studies are approved and funded through a scientific peer-review process and are overseen by the ORP.
Influence of Aliphatic Alcohols on the Hepatic Response to Halogenated Olefins
Authors: Herbert H. Cornish, Mary L. Barth, Bessie Ling
Journal: Environmental Health Perspectives (1977)

The role of alcohols in potentiating the toxicity of halogenated hydrocarbon solvents has been reviewed. The toxicity of carbon tetrachloride and chloroform can be markedly potentiated by prior treatment with ethanol or phenobarbital. Trichloroethylene toxicity may also be potentiated by ethanol ingestion. Prior ethanol ingestion acts by altering biochemical parameters that result in an increased response to subsequent solvent exposure. Simultaneous exposure to both ethanol and trichloroethylene allows for competitive substrate inhibition of metabolism since these compounds share several common enzymatic pathways. Thus the toxic response to multiple exposures varies depending upon the time sequence and the comparative levels of the individual components. Phenobarbital apparently potentiates solvent toxocity by induction of the microsomal mixed function oxidase system. Ethanol, either on a chronic or single dose basis, also has the ability to stimulate this enzyme system. Although alteration of the microsomal mixed function oxidase system by chronic ethanol ingestion may play an important role in potentiation of solvent toxicity, the potentiation seen following a single dose of ethanol cannot be fully accounted for by the known effects of ethanol on the mixed function oxidase system. In addition to ethanol a large number of other alcohols will markedly potentiate the hepatotoxic response to solvents such as carbon tetrachloride and chloroform. The mechanisms involved in such potentiation are not known at the present time.
Evaluation of a new minor tranquilizer: tybamate (Solacen)
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AMP kinase–mediated activation of the BH3-only protein Bim couples energy depletion to stress-induced apoptosis
Authors: Caoimhín G. Concannon, Liam P. Tuffy, Petronela Weisová, Helena P. Bonner, David Dávila, Caroline Bonner, Marc C. Devocelle, Andreas Strasser, Manus W. Ward, Jochen H.M. Prehn
Journal: The Journal of Experimental Medicine (2010)
Statistical Problems in Epidemiologic Studies of the Natural History of Disease
Authors: Ron Brookmeyer
Journal: Environmental Health Perspectives (1990)

The development of effective disease prevention and treatment programs depends on an understanding of the natural history of disease. A conceptual framework is presented for disease natural history and consists of an asymptomatic period of disease followed by a period of symptomatic disease. The focus is on epidemiologic studies for identifying risk factors of the onset of asymptomatic disease, for identifying cofactors of progression to symptomatic disease, and for estimating the duration of the asymptomatic period. The strengths and limitations of various epidemiologic study designs and sources of epidemiologic data are considered for characterizing disease natural history. Issues in the interpretation and analysis of natural history parameters of disease estimated from cross-sectional, prevalent cohort, cohort, and matched case-control studies are considered. The issues and analytic methods are illustrated with studies of the acquired immunodeficiency syndrome (AIDS) and cervical cancer. Based on these analytic methods, an estimate of the incubation period distribution of AIDS is given.
Correction
Journal: BMJ (1894)

90RLEY said lhe was glad to hiear that the funds were distr ibuted imi- partiallY.Ageyd ('ruelty by I Ntirse.-MajorRtAS(Ci[ asked the Presidenit of the ,ocal Government Board whietler ilis attenition halt beeni called to the trial at Brentwood, Essex, of Nurse (
Methsuximide overdose. Delayed onset of profound coma
Authors: S. B. Karch
Journal: JAMA (1973)

To my knowledge, this is the third reported case of methsuximide overdosage. The resulting disorder is biphasic in nature, an apparently benign phase preceding deep coma by a variable number of hours. This sequence, unless anticipated, may lead to potentially lethal results in what otherwise should be a benign condition. The plasma half-life of methsuximide is less than three hours, but a metabolite, 2-methyl-2-phenyl-succinimide, was detected at high levels in the blood of our patient 60 hours postingestion, while the patient was still deeply comatose. The deep coma produced by overdose with methsuximide may be due to the continuing presence of its metabolite, and not to the drug itself. Similar arguments may apply to the antiseizure activity as well.
Renal disease with Staphylococcus albus bacteremia. A complication in ventriculoatrial shunts
Authors: L. Rames
Journal: JAMA (1970)

Three patients had Staphylococcus albus bacteremia as a complication of ventriculoatrial shunts. Each had hematuria, proteinuria, azotemia, acidosis, and anemia; one had the nephrotic syndrome. Two patients' conditions improved after removal of infected shunts; serum complement was reduced in one. Percutaneous renal biopsies showed progressive proliferative and membranous lesions in one patient, proliferative glomerulonephritis in two. Immunofluorescent microscopy showed presence of immunoglobulin in the glomeruli of one and serum complement in two patients. Electron microscopy revealed accumulation of electron-dense, coarsely granular material within the endothelial surface of the basement membrane in all three patients. These findings suggest an immunologic process as the pathophysiologic basis for the renal lesion.
Magazine, Radio and Report
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal