tbuckley/cabot-search huggingface dataset:
277. Clinical Evaluation of Dendritic Cell Vaccination for Patients with Recurrent Glioma: Results of a Clinical Phase I/II Trial
Authors: Ryuya Yamanaka, Junpei Homma, Naoki Yajima, Masakazu Sano, Masuhiro Takahashi
Journal: Molecular Therapy (2006)

Purpose: To investigate the safety, immunological and clinical responses of dendritic cell (DC) therapy for patients with recurrent malignant glioma. Experimental Design: Twenty-four patients with recurrent malignant glioma (6 grade III and 18 grade IV patients) were evaluated in a phase I/II clinical study of DC therapy. All patients were resistant to the standard maximum therapy. The patient's peripheral blood DCs were generated with GM-CSF, plus IL-4 with or without OK-432, and pulsed with an autologous tumor lysate. DCs were injected intradermally, or both intratumorally and intradermally every 3 weeks. Results: The protocols were well tolerated with only local redness and swelling at the injection site in several cases. Clinical responses were: 1 patient with partial response, 3 patients with minor response, 10 patients with stable disease, and 10 patients with progressive disease. The patients who's DCs were maturated with OK-432 had longer survival times than the DCs from patients without OK-432 maturation. The patients with both intratumoral and intradermal administrations had a longer survival time than the patients with intradermal administration only. Increased ELISPOT and DTH responses after vaccination could provide good laboratory markers to predict the clinical outcome of patients receiving DC vaccination. The overall survival of patients with grade IV glioma was 480 days, which was significantly better than that in the control group. Conclusions: This study demonstrated the safety and clinical response of autologous tumor lysate-pulsed DC therapy for patients with malignant glioma. DC therapy is recommended for further clinical studies in malignant glioma patients.
THE EXTENT OF ILLNESS IN THE UNITED STATES
Journal: JAMA (1929)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Double‐Blind, Multicenter Immunotherapy Trial in Children, Using a Purified and Standardized <i>Cladosporium herbarum</i> Preparation II. In Vitro Results
Authors: R. Karlsson, B. Agrell, S. Dreborg, T. Foucard, N.‐I. M. Kjellman, A. Koivikko, R. Einarsson
Journal: Allergy (1986)

This double‐blind immunotherapy trial in children, using a purified and standardized Cladosporium herbarum allergen preparation, has shown that children with mould asthma and/or rhinoconjunctivitis, responded to immunotherapy with a decrease in specific IgE and a significant increase in specific IgG. There was a marked increase in tile ratio specific IgG/specific IgE, as a result of active treatment. IgE‐CRIE radiostaining patterns showed no pronounced changes after 10 months' active treatment and no “new sensitivities” could be detected in the studied patients, IgG‐CRIE radiostaining, primarily directed towards the important allergens, was significantly increased in the active group and particularly towards Ag‐12 (partially identical to a previously described major allergen in Cladosporium herbarum. Ag‐54). Children treated with histamine placebo showed no change antibody patterns during 10 months of treatment.
Multistate Outbreak of &lt;emph type="ital"&gt;Salmonella&lt;/emph&gt; Infections Associated With Frozen Pot Pies—United States, 2007
Journal: JAMA (2009)

On June 6, 2007, a cluster of four human Salmonella serotype I 4,5,12:i:-* infections sharing a pulsed-field gel electrophoresis (PFGE) pattern was identified by the Pennsylvania Department of Health and reported to PulseNet. Initial investigations conducted during June--September 2007 by state and local health departments in collaboration with CDC did not identify a source of infection. This report summarizes the results of subsequent investigations of the outbreak, which determined that 401 cases of salmonellosis occurred in 41 states during 2007, with 32% of ill persons hospitalized. A multistate case-control study conducted during October 3-13 indicated that illness was associated with consumption of Banquet brand frozen, not-ready-to-eat pot pies (odds ratio = 23.6; p<0.001). Further investigation determined that 77% of patients who ate these pies cooked them in microwave ovens and that consumer confusion regarding microwaving instructions might have resulted in a failure to cook the product properly. A voluntary recall was issued by the manufacturer (ConAgra Foods Inc., Omaha, Nebraska) on October 11, 2007, for all nine brands of pot pies produced at the implicated plant (plant A). The outbreak strain was isolated from 13 samples of unopened Banquet pot pies collected from the homes of patients. This outbreak highlights the need to cook not-ready-to-eat frozen foods thoroughly; these products should be clearly labeled as requiring complete cooking, and cooking instructions should be validated to account for variability in microwave wattage and common misconceptions among consumers regarding the nature of not-ready-to-eat foods.
Correction to: MicroRNA in vivo precipitation identifies miR-151-3p as a computational unpredictable miRNA to target Stat3 and inhibits innate IL-6 production
Authors: Xiang Liu, Xiaoping Su, Sheng Xu, Huamin Wang, Dan Han, Jiangxue Li, Mingyan Huang, Xuetao Cao
Journal: Cellular and Molecular Immunology (2019)
Malignant hypertension due to renal artery stenosis. Greater renin release from the nonstenotic kidney
Authors: R. G. McAllister
Journal: JAMA (1972)

In a patient with malignant hypertension, an excretory urogram revealed a nonfunctioning left kidney while aortography demonstrated severe stenosis of the right renal artery. Renal venous renin activity was markedly elevated on the nonstenotic side. Right aortorenal bypass graft together with left nephrectomy resulted in cure of the patient's hypertension. Microscopic study of the resected kidney revealed a severe necrotizing arteriolopathy typical of malignant hypertension. This case is analogous to Floyer's findings in the rat. The intrarenal arteriolopathy of malignant hypertension is responsible for the paradoxically elevated renin activity from the nonstenotic kidney.
Risks for Persistent Clots in Leg Veins despite Treatment
Journal: Annals of Internal Medicine (2002)

Summaries for Patients17 December 2002Risks for Persistent Clots in Leg Veins despite TreatmentSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-137-12-200212170-00003 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Sometimes adults get blood clots in their veins, a condition known as deep venous thrombosis (DVT). The blood clots usually form in leg veins. Blood clots in the deep veins of the legs are dangerous because they can break free and travel to the lungs. This problem, called pulmonary embolism (clot in the lung), can be fatal. Doctors typically treat patients with DVT with blood-thinning drugs for 3 to 6 months. The blood-thinning drugs help dissolve clots, reduce the risk that a clot will travel to the lungs, ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Residual Venous Thrombosis as a Predictive Factor of Recurrent Venous Thromboembolism.” It is in the 17 December 2002 issue of Annals of Internal Medicine (volume 137, pages 955-960). The authors are P Prandoni, AWA Lensing, MH Prins, E Bernardi, A Marchiori, P Bagatella, M Frulla, L Mosena, D Tormene, A Piccioli, P Simioni, and A Girolami.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoResidual Venous Thrombosis as a Predictive Factor of Recurrent Venous Thromboembolism Paolo Prandoni , Anthonie W.A. Lensing , Martin H. Prins , Enrico Bernardi , Antonio Marchiori , Paola Bagatella , Michela Frulla , Laura Mosena , Daniela Tormene , Andrea Piccioli , Paolo Simioni , and Antonio Girolami Metrics 17 December 2002Volume 137, Issue 12Page: I-32KeywordsBloodDrugsLungsPulmonary embolismRespiratory system proceduresSigns and symptomsThrombosisUltrasound imagingVeinsVenous thromboembolism ePublished: 17 December 2002 Issue Published: 17 December 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Managed care may feature behavioral medicine
Authors: C. Marwick
Journal: JAMA (1996)

AS MANAGED CARE groups become major players in providing and financing health care services, experts in behavioral medicine see a golden chance to fulfill their objective of integrating psychosocial with biomedical approaches to health and illness. "The impetus for behaviorial and psychosocial approaches in disease prevention, treatment, and rehabilitation comes from public health and the efforts to change lifestyles. Along with this has come an interest in health care utilization, so there's an opportunity here," said C. Barr Taylor, MD, speaking at the Fourth International Congress of Behavioral Medicine, held in Washington, DC. "We think that, as more capitated systems take over in health care, this gives us the chance to intervene and apply new models that might be successful in treating illness. At least 25% of the patients in a primary care practice present with emotional problems, like anxiety, depression, or drug or alcohol abuse," Taylor said. He is
GMC to seek comments on advertising guidelines
Journal: BMJ (1986)

+1) 1(-2) House officer 87 (-4) 89 (0) 69 (+ 1) 77 (+6) 1(-4) Senior house officer -86 (-2) 83 (+1) 56(-2) 66(-1) 1 (-1) Registrar 86 (-2) 81 (-5) 53 (-2)
&lt;TITLE&gt;Heart Emergencies Caused by Irregular Heartbeat&lt;/TITLE&gt;
Journal: JAMA (2001)

public service of JAMA.The information and recommendations appearing on this page are appropriate in most instances, but they are not a substitute for medical diagnosis.For specific information concerning your personal medical condition, JAMA and the AMA suggest that you consult your physician.This page may be reproduced noncommercially by physicians and other health care professionals to share with patients.Any other reproduction is subject to AMA approval.
JAMA Cardiology
Authors: Phil Fontanarosa, Annette Flanagin, Brenda Deputy, Tracy Frey, Iris Lo, Kevin Brown, Rebecca Langley, Suzanne Newman, Connie Manno Senior, Sara Billings, Doug Brandt, Timothy Gray, Juliet Orellana, Paul Ruich, Kirby Snell, Judith Ahlers, Catherine Alden, Stephanie Beckmeyer, Jane Calayag, Jan Clavey, Mary Coerver-Connolly, Heather Flint, Bernadette Hromin, Ruth Kaufman, Laura King, Julia Kurtz, Jenny Mackay, Tanya Martin, Molly O'donnell, Charon Pierson, Lori Ryan, Thressa Smith, Divya Sreekumar, Annette Theuring, Donna Thordsen, Christine Tilles, Caroline Woods, Editorial Assistant, Wanda Hill, Larry Bryant, Jacob Kendall-Taylor, Monica Managers, Fanny Staff, Anna Brown, Lee Bukowski, Lenette Calibeo, Tosca Gardner-Gullens, Erin Hall, Rachell Kato, Kenneth Lozano, Caroline Otani, Angelia Sietmann, Michael Berkwits, Eric Butkus, Jesse Mcquarters, Elena Guobyte, Emily Ling, Daniel Morrow, Social Media, Eman Hassaballa, Reuben Rios, Mary Ferkaluk, Karen Bucher, Andy Rekito, Nick Reback, Lohitha Kethu, David Song, Deputy Livingston, Thomas Cole, Administration Director, Marla Jeff, Deanna Willis, Yolanda Davis, Joseph Thornton, Deanna Bellandi, Jim Michalski, Julie Burton, Ronna Hewitt, Mary Sieck, Geneine Someren, Jamaal Vargas, Content Systems, Mike Bujewski, Nathan Mitre, Digital Production, Regina Brownlee, Amanda Camino, Brenda Chandler-Grayer, Emily Dunn, Amy Evers, Maleeka Holden, Teri Hutchison, Dan Knowles, Joshua Lampinen, Natalie Marsh, Patricia Panek, Marla Seidell, La Son, Diggs Sledge, Julian Graphics, Joe Amft, James Collver, Maria Duda, Fred Furtner, Carolyn Hall, Maria Kowalkowski, Joy Farrell, Maria Giannini, Sasha Grossman, Judith Literskis, Teresa Omiotek, Michael Ryder, James Madara, Howard Bauchner, Robert Bonow, Patrick O'gara, Marc Sabatine, Clyde Boston, Michael Pencina, Carolina North, Adrian Hernandez, Mhs Durham, North Carolina, Mark Huff Man, Ajay Kirtane, New York, Roxana Mehran, Ann Navar, Carolina Christopher, J O'donnell, Massachusetts Boston, J Sanjiv, Mintu Shah, Gregg Fonarow, Los Angeles, Elizabeth Mcnally, Laine Thomas, Akhil Narang, Julia Getts, Eugene Braunwald, Robert Califf, Judith Hochman, Donald Lloyd-Jones, Scm Chicago, Michael Parmacek, Daniel Simon, Sidney Smith, Chapel Hill, Carolina Douglas, E Vaughan, Myron Weisfeldt, Maryland Douglas, P Zipes, Paul Armstrong, Shinya Goto, Peter Liu, Renato Lopes, Carolina Maseri, Dorairaj Prabhakaran, Hugh Watkins, Harvey White, Habib Yacoub
Journal: JAMA Cardiology (2020)
SOCIAL WORK FOR THE HARD OF HEARING
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The adaptive imbalance in base excision–repair enzymes generates microsatellite instability in chronic inflammation
Authors: Lorne J. Hofseth, Mohammed A. Khan, Mark Ambrose, Olga Nikolayeva, Meng Xu-Welliver, Maria Kartalou, S. Perwez Hussain, Richard B. Roth, Xiaoling Zhou, Leah E. Mechanic, Irit Zurer, Varda Rotter, Leona D. Samson, Curtis C. Harris
Journal: Journal of Clinical Investigation (2003)

Chronic infection and associated inflammation are key contributors to human carcinogenesis. Ulcerative colitis (UC) is an oxyradical overload disease and is characterized by free radical stress and colon cancer proneness. Here we examined tissues from noncancerous colons of ulcerative colitis patients to determine (a) the activity of two base excision–repair enzymes , AAG, the major 3-methyladenine DNA glycosylase, and APE1, the major apurinic site endonuclease; and (b) the prevalence of microsatellite instability (MSI). AAG and APE1 were significantly increased in UC colon epithelium undergoing elevated inflammation and MSI was positively correlated with their imbalanced enzymatic activities. These latter results were supported by mechanistic studies using yeast and human cell models in which overexpression of AAG and/or APE1 was associated with frameshift mutations and MSI. Our results are consistent with the hypothesis that the adaptive and imbalanced increase in AAG and APE1 is a novel mechanism contributing to MSI in patients with UC and may extend to chronic inflammatory or other diseases with MSI of unknown etiology.
The effect of zinc and erythromycin on the growth of erythromycin-resistant and erythromycin-sensitive isolates of Propionibacterium acnes: an in-vitro study
Authors: K. T. HOLLAND, R. A. BOJAR, W. J. CUNLIFFE, A. G. CUTCLIFFE, E. A. EADY, L. FAROOQ, A. M. FARRELL, E. M. GRIBBON, D. TAYLOR
Journal: British Journal of Dermatology (1992)
THE STUDY OF THE HISTORY OF MEDICINE.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Psychiatry's agenda for the '80s
Authors: J. A. Talbott
Journal: JAMA (1984)

It is often said that psychiatry as a science is in its infancy. To me, however, it seems that we've passed through infancy and a very stormy adolescence and are now looking somewhat eagerly yet apprehensively at adulthood—with all the opportunities and problems that phase of life contains. Certainly, much of psychiatry's future parallels that of the rest of medicine. We are all preoccupied with cost containment and its inevitable impact on our practices, patients, and personal incomes. Whether it's the alphabet soup of governmental initiatives such as DRGs, PPOs, or PROs, the increasing impact of third-party constraints, or the specter of proprietary businesses intruding into medicine, we know we will never practice medicine again in the way we have grown accustomed to. Our members are moving from solo practice to "organized settings," our patients are paying with insurance and not personal savings, and our practices are burdened by increasing
The Firearm Fatality Reporting System. A proposal
Authors: S. P. Teret
Journal: JAMA (1992)

RECOMMENDATION: [R]equire that firearm injuries, in addition to being reportable to the police, be reportable to health departments. Place greater emphasis on coding the type of firearm on the death certificate. Develop a national fatal firearm injury reporting system, comparable to FARS [Fatal Accident Reporting System], with sufficient data for documenting the firearm problem and designing prevention strategies. —from<i>Cost of Injury in the United States</i><sup>1</sup> Firearms are the vehicle of death for approximately 34 000 people each year in the United States. The estimated lifetime costs for firearm injuries that occurred in 1985 will be $14.4 billion.<sup>1</sup>Firearm policy, as expressed most often through legislation, is in part health policy. For groups such as young African-American males, for whom almost half of all deaths are caused by gunfire,<sup>2</sup>gun policy may be more influential to their health status than any other form of health policy. But
Spontaneous acceptance of rat liver allografts is associated with an early downregulation of intragraft interleukin-4 messenger RNA expression*1, *2
Authors: O FARGES
Journal: Hepatology (1995)

Liver allografts are not rejected in the fully incompatible Lewis-RT11 (LEW) to blood group D Agouti-RT1a (DA) rat strain combination despite an early infiltration by recipient mononucleated cells that initially display a phenotype, an ability to respond to interleukin-2 (IL-2) and donor-specific cytotoxicity indistinguishable from that observed in the rejected, DA to LEW combination. To further analyze the mechanism of this tolerance, we have compared in these two combinations, as well as in syngeneic grafts and in normal livers, the presence of intrahepatic cytokine transcripts (IL-1α, IL−2, IL−4, IL−6, IL−10, tumor necrosis factor [Tnf]-α, TNF-β, and transforming growth factor [Tgf]-β) by a semiquantitative polymerase chain reaction (PCR) or by northern-blotting. In normal livers or syngeneic grafts, IL-1α, TNF-β, and TGF-β were the only cytokines detected by these methods. The levels of all cytokine transcripts were increased in allogeneic grafts. Expression of cytokine transcripts was very similar in the two allogeneic strain combinations except IL−4, which was expressed at a much lower level in the nonrejected strain than in the rejected strain from day 2 onward. We conclude that selective downregulation of IL−4 gene expression is associated with, and a potential mediator of, the induction of tolerance in this model.
Assessing Authority
Authors: Drummond Rennie, Iain Chalmers
Journal: JAMA (2009)

At the beginning of the 1990s, Antman and a team led by Tom Chalmers and Fred Mosteller used retrospective cumulative meta-analysis to show that the treatment recommendations of authorities in review articles and textbook chapters published over the previous 30 years had not reflected the best contemporary research evidence. These gaps between evidence and advice, which had sometimes lasted more than a decade, meant that both effective and dangerous treatments had been overlooked. The article by Antman et al published in JAMA in 1992 provided powerful evidence that traditional, unsystematic, narrative reviews did not serve patients well, and that better systems for gathering, analyzing, and disseminating clinical information were urgently required.See PDF for full text of the original JAMA article.