tbuckley/cabot-search huggingface dataset:
CONCERNING MERCURIAL EXANTHEMATA AND IDIOSYNCRASY TO MERCURY.
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction: <i>Oncolytic adenovirus and gene therapy with EphA2-BiTE for the treatment of pediatric high-grade gliomas</i>
Authors: Brennan Decker, Richard S.P. Huang, Karthikeyan Murugesan, Douglas A. Mata, Jeffrey S. Ross, Matthew Hiemenz, Gerald Li, James Creeden, Shakti H. Ramkissoon
Journal: Journal for ImmunoTherapy of Cancer (2021)
Further Autoradiographic Studies of the Lens Epithelium
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE POSSIBILITIES OF COTTONSEED FLOUR AS FOOD
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Myelotoxicity Induced in Female B6C3F1 Mice by Inhalation of Methyl Isocyanate
Authors: H. L. Hong, J. R. Bucher, J. Canipe, G. A. Boorman
Journal: Environmental Health Perspectives (1987)

The effects of a 4-day inhalation exposure (6 hr/day) to 0, 1, and 3 ppm methyl isocyanate (MIC) on bone marrow parameters in female mice were examined at 5, 8, and 21 days following exposure. The MIC exposure was associated with myelotoxicity as evidenced by hypocellularity, suppression of pluripotent stem cells (CFU-S), granulocyte-macrophage progenitors (CFU-GM) and erythroid precursors (CFU-E) in both dose groups. Hematopoietic parameters returned to normal by 21 days in the 1 ppm dose group, but not in the 3 ppm dose group. This indicates that the alterations in the bone marrow parameters persist for a relatively long period at dose levels where there are little or no changes in body weight, clinical pathology, or immunological parameters, suggesting that the bone marrow may be a sensitive endpoint for MIC exposure in mice. MIC is a highly reactive chemical that appears to exert its effect directly on the lining epithelium of the nasal cavity and major airways; there was no histological evidence of a systemic effect. The pathogenesis of the bone marrow depression is unknown; however, there were chronic bronchitis and bronchial fibrosis in the 3 ppm dose group. One possible explanation is that the cell injury induced in the lung is associated with the release of inhibitory factors for hematopoiesis, as the rodent lung is a potent source of both stimulatory and inhibitory growth factors for bone marrow progenitor cells. A second possibility is that the thymic atrophy found in MIC-exposed mice might be related to myelotoxicity. The pathogenesis of myelotoxicity in MIC exposure and its relationship with pulmonary injury require further study.
Amenorrhea and galactorrhea following oral contraceptive therapy
Authors: S. Friedman
Journal: JAMA (1969)

Twenty-one patients had complete amenorrhea or anovulatory cycles for one or more years following the use of oral contraceptives. Nine also had galactorrhea. There was an increased incidence of preexisting menstrual irregularities among these patients, and only four had been pregnant before. Marriage or some other environmental change was usually associated with the start of oral contraceptive therapy. One patient had taken a sequential agent; the remainder had used combination-type agents. These patients did not significantly differ from those with secondary amenorrhea not related to use of oral contraceptives in either their clinical symptoms or response to treatment. This study was not able to demonstrate a definite cause and effect relationship between oral contraceptive therapy and the ensuing amenorrhea or galactorrhea.
GASOLINE INTOXICATION
Authors: WILLARD MACHLE
Journal: JAMA (1941)

Although poisoning by petroleum distillates has been a recognized clinical condition ever since these products began to find commercial use, few cases have been reported, probably because they are of sporadic occurrence and in cases of mild acute poisoning recovery is usually prompt and complete. Opportunities for harmful exposure are frequent however, and, as gasoline has become a material essential in daily life and its distribution is constantly increasing, intoxication by gasoline will doubtless become more, rather than less, frequent. The monthly consumption of gasoline in the United States increased from about 1,000,000,000 gallons in 1927 to more than 2,000,000,000 gallons in 1940,<sup>1</sup>and this was due almost entirely to its increased use as a motor fuel. As a result, the persons having a possible exposure to gasoline include greater numbers of motorists and also greater numbers of men employed in its production, distribution and marketing. The number of
VITAMIN D AND CALCIUM IN FOODS
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Time for new head, new approach at OAM
Authors: C. Marwick
Journal: JAMA (1994)

WHEN Joseph J. Jacobs, MD, MBA, announced that he was resigning as director of the National Institute of Health's (NIH) Office of Alternative Medicine (OAM) this past summer, his decision was widely viewed as a setback in the effort to evaluate unconventional medical practices. But in another light, it is also an opportunity for the proponents of so-called alternative medicine to take a serious look at the office's program and to lay out a realistic and productive plan to achieve the goals all the parties say they want. Whether this will happen depends on the resolution of a number of disparate opinions about the whole approach to evaluating unconventional therapies, the specific priorities to be selected from a broad variety of treatments, and, perhaps most important, the development of a spirit of trust among the parties involved and a willingness by alternative medicine's sponsors to deal with the realities of
Vorinostat Synergistically Potentiates MK-0457 Lethality in Chronic Myelogenous Leukemia (CML) Cells Sensitive and Resistant to Imatinib Mesylate.
Authors: Yun Dai, Shuang Chen, Charis A. Venditti, Tri K. Nguyen, Paul Dent, Steven Grant
Journal: Blood (2007)
MEDICAL PREPAREDNESS
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Selective Induction of DNA Synthesis in Mouse Preneoplastic and Neoplastic Hepatic Lesions after Exposure to Phenobarbital
Authors: James E. Klaunig
Journal: Environmental Health Perspectives (1993)

Recent evidence has suggested that the induction of DNA synthesis by nongenotoxic chemical carcinogens plays an important role in the formation of cancer.The present study examined the effect of a nongenotoxic carcinogen, phenobarbital, (PB) on the induction of DNA synthesis in preneoplastic foci and adenomas in B6C3F1 mice.Male mice were treated with diethylni- trosamine at 30 days of age.After 6 months, mice had both hepatic foci and adenomas.Mice were divided into three groups at random and treated with PB in the drinking water and exam- ined for DNA labeling by autoradiography.Before sacrifice, each mouse received an osmotic minipump containing [3H] thymidine.Results showed a PB dose-dependent increase in DNA synthesis in hepatic foci.Adenomas were unresponsive to the DNA synthesis-enhancing effect of PB, maintaining a level of 20-25%.The nornal surrounding liver showed an increase in DNA synthesis (10-15% labeling index) at the 7-day sampling, which returned to normal control lev- els by 28 and 45 days.The foci showed a heterogeneity in response, with some foci showing an increase (20-30o labeling index), and others maintaining control DNA synthesis levels (4-6% labeling index).These results show that preneoplastic foci in the mouse respond preferentially to the induction of DNA synthesis by PB, that this response is dose dependent, and that it is maintained as long as the treatment continues.
CROUPOUS PNEUMONIA.
Authors: J. M. ALLEN
Journal: JAMA (1901)

The old masters of our profession had very imperfect ideas of etiology, therefore taught faulty therapeutics. They thought croupous pneumonia to be the result of fluctionary changes in the blood brought about by cold, etc. They had an incorrect idea of the character of the cause of the first step in the process of inflammation, that is, irritation caused by bacteria. They recognized the buffy coat of the blood and the rapid increase of fibrin in pneumonia, their essentials in the inflammatory process. The correction of this condition was to be accomplished by rapid depletion; hence blood-letting one or more times untilthe radial artery ceased to be strong and corded. Next followed the revulsion by what they termed an emeto-cathartic composed of 10 grs. hydrargyri chloridum mite, 10 grs. pulvis jalapæ, and 2 or 3 grs. of antimonii et potassii tartras. From the beginning of the attack the patient was
Cardiopulmonary Resuscitation
Authors: Richard L. Coskey
Journal: JAMA (1971)

<h3>To the Editor.—</h3> Dr. Stolfi illustrated an interesting mechanical adjunct to cardiopulmonary resuscitation (CPR) (<b>216</b>:678, 1971). A fundamental concept in CPR instruction is that instrumentation is unnecessary for emergency resuscitation techniques. Utilization of a mechanical device would decrease the number of persons qualified to offer CPR (qualified by virtue of possession of such a device) as well as limit the number of patients whose body build would be compatible with a specific device. Children or patients with unusual jaw structure would be examples. One would wonder about potential air leakage around and within the stainless steel collapsible and folding device. One would wonder if any such device could have universal application. If not, in what percentage of the population would such a device be appropriate? A well-trained person can offer closed chest cardiac massage and respiratory support without the benefit of a nose clip. To carry a nose clip
Surgeons View Anesthesia, Viruses, Injuries
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 1768: Biochemical and structural analysis of the Neurofibromin (NF1) protein and a potential role for protein destabilization in Rasopathy diseases
Authors: Mukul Sherekar, Sae-Won Han, Simon Messing, Matthew Drew, William Gillette, Claire Lorenzo, Frank McCormick, Dominic Esposito
Journal: Cancer Research (2019)

Abstract Neurofibromin is the 320 kilodalton protein product of the NF1 gene which is mutated in the Rasopathy disease Neurofibromatosis Type I. Defects in NF1 lead to abrogation of the GTPase activating activity of the protein, leading to aberrant signaling through the RAS-MAPK pathway. Very little is known about the function of the majority of the NF1 protein—to date only the GAP domain and a region containing a Sec-PH motif have detailed structural information. To better understand the role of this large protein, we have carried out a series of biochemical and biophysical studies which clearly show that full length NF1 protein exists primarily as a dimer. Data from in vivo experiments confirmed that this dimerization also occurs in cells, and presumably has biological implications. A model was generated from negative-stain EM data which suggests that NF1 monomers form both intermolecular contacts to form dimers and intramolecular contacts which stabilize the individual monomers. Deletion analysis permitted us to map these two interacting domains to different parts of the NF1 protein, and crosslinking studies coupled with mass spectrometry helped to identify regions of possible interaction. In addition, introduction of point mutations observed in patients with NF diseases caused a dramatic decrease in the stability of proteins both in vitro and in vivo, potentially arguing for a rationale for loss of NF1 activity by these single mutations Citation Format: Mukul Sherekar, Sae-Won Han, Simon Messing, Matthew Drew, William Gillette, Claire Lorenzo, Frank McCormick, Dominic Esposito. Biochemical and structural analysis of the Neurofibromin (NF1) protein and a potential role for protein destabilization in Rasopathy diseases [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1768.
Reading for a desert island
Authors: R. Armour
Journal: JAMA (1969)

The next time I am asked what book I would like to have if I were marooned on a desert island, I know my choice. It would be the<i>New English Dictionary</i>(1888-1933). Running to 11 huge volumes of small print, it would last me a long time, perhaps until someone picked up my note in an empty cough-syrup bottle and sent out a rescue party. The<i>NED</i>is crammed with fascinating information not usually included in a dictionary. In addition to the usual meanings and etymologies, it quotes from works dating back hundreds of years, and thus combines lexicography and history. Recently I opened the M-N volume, thinking to look up the word "medical." I already knew the ordinary things about the word, such as its coming from the Latin<i>medicus</i>, physician, and being akin to<i>mederi</i>, to heal, and<i>remedium</i>, remedy. I also knew that it can be
Medical Learning
Authors: Gerald D. Denton
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cognitive Remediation
Authors: ROBERT D. OADES
Journal: American Journal of Psychiatry (1994)

drew attention to the neglect of cognitive remediation in the literature.His treatment of the successes and failure and his recommendations emphasize the study of groups -a necessity for a research strategy.I suggest that a recipe with a chance of therapeutic success must be individually tailored.A feature that he does not highlight is the increasing feasibility of imaging brain areas with anomalous activity during specific task performance.
Amer J of Roentgenology, Springfield, Ill
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal