tbuckley/cabot-search huggingface dataset:
Drug Abuse
Authors: Barry Liskow
Journal: JAMA (1972)

<b>The Drug Abuse Controversy,</b>edited by Clinton C. Brown and Charles Savage, 270 pp, with illus, $8.50, Friends Medical Science Research Center, National Educational Consultants (711 St. Paul St, Baltimore 21202), 1972. Of the recent flood of books on drug abuse few have been aimed specifically at the practicing physician. It is, therefore, fortunate that the proceedings of the International Conference on Drug Abuse held in Ann Arbor, Mich, in November 1970, have come to print, for, if read, they will go a long way toward achieving the stated goal, "to help the practicing physician deal more effectively with the problems of drug abuse." The well-organized five-day conference, with its 59 speakers, was divided into sections dealing separately with opiate, sedative, stimulant, hallucinogen, and cannabis use and abuse; epidemiology; legal aspects; psychiatric management; and community action problems related to drugs. Each subject was covered by several acknowledged experts, most of
Guidelines for Establishing Sexual Harassment Prevention and Grievance Procedures
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 494: Differences in Sarcoplasmic Reticulum Ca <sup>2+</sup> Loading and Spontaneous Ca <sup>2+</sup> Release in Permeabilized Sinoatrial Nodal and Ventricular Myocytes: Effect of cAMP.
Authors: Syevda G. Sirenko, Alexey E. Lyashkov, Dongmei Yang, Edward G. Lakatta, Tatiana M. Vinogradova
Journal: Circulation (2007)

To maintain their normal automaticity, sinoatrial nodal cells (SANC) have a unique property to generate spontaneous, local Ca 2+ release (LCR) from sarcoplasmic reticulum (SR) under physiological conditions. To further characterize the mechanisms that underlie LCR’s, we compared SR Ca 2+ loading and release in saponin permeabilized, rabbit SANC and ventricular myocytes (VM) over a wide range of free [Ca 2+ ] in a physiological buffer containing 0.5 mM EGTA. The SR Ca 2+ load, indexed as Ca 2+ released by a rapid application of caffeine, was assessed by a confocal linescan image as the amplitude of Fluo-4 of Ca 2+ fluorescent transient (F/F 0 ); total spontaneous LCR signal mass during a 400 ms period over 100 μm was assessed by integrating the fluorescence of each LCR and summating the integral of all LCR’s. Over a range of free [Ca 2+ ] from 50 to 200 nM SR Ca 2+ load was the same in two cell types (Fig. A ), but at 250 nM SR load it doubled in VM, but not in SANC. Failure of SANC SR load to further increase may be attributed to the exaggerated spontaneous LCR: at 200 nM free Ca 2+ , spontaneous LCR signal mass was 4-times greater in SANC than in VM. A greater LCR signal mass in SANC than in VM at an equal or lesser SR Ca 2+ load indicates that spontaneous Ca 2+ release mechanisms differ in 2 cell types, possibly, on the basis of a recent report of high basal levels of cAMP/PKA phosphorylation in SANC. When VM were exposed to cAMP (10 μM) spontaneous LCR signal mass markedly increased (Fig. B ) at a constant Ca 2+ load (150 nM [Ca 2+ ]i Fig. A ). Thus, in physiological [Ca 2+ ], spontaneous LCR’s differ in SANC vs VM, and this may be explained, in part at least, by high basal cAMP/PKA phosphorylation of Ca 2+ cycling proteins in SANC.
Intracranial meningioma in factor IX deficiency
Authors: S. Gendelman
Journal: JAMA (1978)

RECENT advances in hemophilia research and development have led to a considerable decrease in mortality and morbidity in congenital factor VIII and IX deficiency states. Intracranial surgical intervention, once a procedure to be avoided except as a last-resort laternative, can now be used as readily as it would be in patients without these hemorrhagic disorders.<sup>1-4</sup>The availability of concentrated factors VIII and IX and methods for calculating and quantitating their in vivo levels and halflives have revolutionized the treatment of hemophilia.<sup>5</sup>As stated by Britten,<sup>6</sup>the problem in 1959, had changed "from how to stay alive to how to keep well" and in 1971, "from how to keep well to how to live well." Intracranial complications in hemophiliacs have long been recognized. Intracranial neoplasms, however, have been rarely reported.<sup>7</sup>The establishment of the successful evaluation, diagnosis, and surgical removal of an intracranial neoplasm has never been
Now read this: the SI units are here
Authors: G. D. Lundberg
Journal: JAMA (1986)

As of July 1, 1986, in all articles appearing in<i>JAMA</i>and the nine AMA specialty journals, clinical laboratory data will be expressed in conventional units followed in parentheses by Système International (SI) units. This is the first phase of our two-year conversion to SI—the measurement system currently in use by most of the world, as discussed previously in this and other AMA journals.<sup>1-4</sup>This gradual transition was designed to allow time for learning and is in keeping with the recommendation of the AMA Council on Scientific Affairs, which was adopted by the House of Delegates as policy in December 1984: "4. Develop and implement an educational effort for all physicians to assist them in making an error-free clinical conversion to SI units."<sup>2</sup> Promoted by the American National Metric Council (ANMC) and supported by many organizations, the conversion to SI units was mandated by the House of Delegates
Intestinal Lipogenesis by Alcohol
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hemorrhage and Shock Associated With Invasive Pneumococcal Infection in Healthy Infants and Children—New Mexico, 1993-1994
Journal: JAMA (1995)

From December 1993 through May 1994, four previously healthy children (including two infants) in New Mexico developed a severe illness characterized by septic shock and hemorrhage into the skin or internal organs. An investigation subsequently implicated Streptococcus pneumoniae as the cause of illness. The two infants attended the same child care center (CCC) and died 6 weeks apart. This report describes the syndrome, an investigation of potential transmission in the CCC, and prevention measures.
Systemic mastocytosis associated with presence of rheumatoid factor
Authors: J. Ritz
Journal: JAMA (1976)

We encountered a case of systemic mast cell disease associated with rheumatoid factor; to our knowledge, this has not been reported in the literature. Rheumatoid arthritis as an unrelated second disease cannot be excluded, but there is support for a relation between joint symptoms, rheumatoid factor, and the mast cell disease. (<i>JAMA</i>235:1586-1587, 1976)
MASTOIDITIS IN INFANTS
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Modern Medicine: Its Progress and Opportunities
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE FATE OF THE IDIOT.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Chemotherapy of Cancer
Authors: Thomas C. Hall
Journal: New England Journal of Medicine (1962)

Miscellaneous Agents Hormones. The steroid hormones were among the first agents used in cancer therapy. The uniquely specific stimulus-response relations causing proliferation of the tissues in secondary sex organs naturally led to attempts at surgical removal of gonadal sources of estrogen in breast cancer168 and androgen in cases of prostatic carcinoma.169 Administration of exogenous sex hormones followed naturally. Hormonal treatment of breast carcinoma has shown a gratifying number of beneficial responses and, having recently been reviewed in this series,170 will not be discussed at this time. Brief mention of the progestational agents, however, is in order. These agents have been . . .
QUARANTINE OF THE TUBERCULOUS.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A NEW COMBINED BLOOD TRANSFUSION AND ASPIRATING MACHINE
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Informed consent: II
Authors: L. J. Miller
Journal: JAMA (1980)

IN THE preceding article (244:2100-2103, 1980), the nature of the doctrine of informed consent and various issues relating to the elements of a cause of action based on lack of informed consent were discussed. This article discusses various defenses to informed consent claims. <h3>DEFENSES TO INFORMED CONSENT CLAIMS</h3> There are a number of defenses to a claim of lack of informed consent. Some of these relate to the lack of materiality of the risk that was allegedly not disclosed. Others relate to standards of medical practice or to the question of proximate cause of the patient's injury. The major defenses have all been listed in a large number of cases and appear to be recognized in a large majority of jurisdictions. Unfortunately, however, the scope of the various defenses is extremely unclear, for two reasons. First, the applicability of such defenses depends primarily on the facts of the particular case. It
Food-Allergic Adolescents at Risk for Anaphylaxis: A Randomized Controlled Study of Supervised Injection to Improve Comfort with Epinephrine Self-Injection
Authors: Christine D'Urso, Christopher Knight, Melissa Rubes, Kinga Picerno, Ailie Posillico, Zara Atal, Rachel Annunziato, Eyal Shemesh, Scott H. Sicherer
Journal: Journal of Allergy and Clinical Immunology (2017)
Journal National Med Association, New York
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Special Award
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diagnosing Syncope
Authors: Paul I. Roda
Journal: Annals of Internal Medicine (1998)

Letters15 January 1998Diagnosing SyncopePaul I. Roda, MDPaul I. Roda, MDNorth East Medical Oncology; Hazleton, PA 18201Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-2-199801150-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The 15 June 1997 issue of Annals contained an interesting juxtaposition of articles. The first is a position paper produced by the Clinical Efficacy Assessment Project of the American College of Physicians [1] on diagnosing syncope. An expert panel reviewed the appropriate workup for patients with syncope and noted that “routine use of basic laboratory tests is not recommended … .” Immediately following this position paper is an essay, “What's Wrong with This Picture?” [2], that describes a patient with isolated syncope. This patient has a thorough cardiac evaluation that fails to detect his colon carcinoma. One ...References1. Linzer M, Yang EH, Estes NA 3d, Wang P, Vorperian VR, Kapoor WN. Diagnosing syncope. Part 1: Value of history, physical examination, and electrocardiography. Ann Intern Med. 1997; 126:989-96. Google Scholar2. Brody SA. What's wrong with this picture? Ann Intern Med. 1997; 126:997-8. Google Scholar Author, Article, and Disclosure InformationAuthors: Paul I. Roda, MDAffiliations: North East Medical Oncology; Hazleton, PA 18201 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 January 1998Volume 128, Issue 2Page: 155KeywordsColonColorectal cancerComplete blood countHeart failureHemorrhageIron deficiencyLaboratory testsLesionsResearch laboratoriesSyncope ePublished: 15 August 2000 Issue Published: 15 January 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Language
Authors: Roderick Saxey
Journal: JAMA (1978)

<h3>To the Editor.—</h3> Only praise and encouragement can be offered for Dr Martin's efforts to raise the level of artistic expression in medical communication (239:2776, 1978). Any help physicians can receive in making human the sterile scientism of their profession must be applauded. Nevertheless, one minor observation is in order, not as criticism but as comment on an area of study unfamiliar to most physicians. Dr Martin implies that "early language" was simpler than our own, containing fewer words and capable of less precise speech, and that people used metaphors and poetic allusions to overcome this deficiency. Alas, the evolutionary principle on which this view of language change is based, efficient though it is in understanding the world of biology and despite its initial stimulating effect on anthropology, has proved an enormous stumbling block to the study of society in general and linguistics in particular. The fact is that no
Estrogen Replacement Therapy in Breast Cancer Survivors
Authors: Rena Vassilopoulou-Sellin
Journal: JAMA (1995)

<h3>To the Editor.</h3> —We wholeheartedly applaud the suggestion by Dr Cobleigh and colleagues<sup>1</sup>that the role of ERT in the care of postmenopausal women with a history of breast cancer should be defined in a thoughtful and broad-minded manner through carefully designed prospective clinical trials. The realization that omission of the ERT option may no longer be appropriate for all women previously treated for breast cancer has led us to initiate such a prospective study, as the authors point out.<sup>2</sup>During our interactions with postmenopausal women with prior diagnosis of breast cancer, both within our institution<sup>3</sup>and in the community, we are impressed by their compelling descriptions of the deleterious effects of estrogen deficiency on their sense of well-being. The principle that no one medical intervention is ever appropriate for all individuals appears intuitively obvious but merits repetition. We would like to caution that neither ERT nor