tbuckley/cabot-search huggingface dataset:
Atherosclerosis in Rhesus Monkeys: VII. Mechanism of Hypercholesteremia
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
April 10, 2002
Journal: JAMA (2002)

Nina S. Kadan-Lottick, MD, MSPH; Leslie L. Robison, PhD; James G. Gurney, PhD; Joseph P. Neglia, MD, MPH; Yutaka Yasui, PhD; Robert Hayashi, MD; Melissa Hudson, MD; Mark Greenberg, MB, CHB; Ann C. Mertens, PhD
THE ANTI-STREPTOCOCCIC SERUM.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Code of Ethics.
Authors: None F. W. T.
Journal: JAMA (1893)

<h3>To the Editor of the Journal of the American Medical Association:</h3><h3>Dear Sir:</h3> —I like the<i>tone</i>in which Dr. Edward Jackson presents his objections to the Code of Ethics of the American Medical Association, but I do not see the<i>force</i>of his objections. What I have to say on this subject I do not wish to be considered as applicable to him. His line of reasoning, however, would apply to all moral codes, written or understood. It is true that we all know of cases where members of this Association, and of our local societies have violated that part which forbids regular physicians to consult with quacks and irregulars, and we are as familiar with similar or even grosser violations of the moral law by members of society and of churches, which certainly do not warrant abandonment of all standards of morals. As in one case so in
Electronic Games
Authors: James S. Greene
Journal: JAMA (1982)

<h3>To the Editor.—</h3> The published reports of injuries related to the increasing popularity of electronic games is scanty at best. An interesting case was seen in our emergency department several weeks ago that we believe may represent a problem seen frequently but not recognized readily. <h3>Report of a Case.—</h3> A 40-year-old man came to our emergency department with the complaint of severe dull pain in his right elbow that would gradually spread distally to involve the right forearm and wrist and proximally to the right upper arm and shoulder. There was no history of trauma or arthritis. On examination, the patient was afebrile. He had severe tenderness of both medial and lateral epicondyles, where both the pronators and supinators, respectively, of the forearm originate. There was no evidence of effusion, erythema, or limitation of motion. Results of further workup were essentially normal. The patient was treated conservatively with an anti-inflammatory
Abstract 15214: Commuting by Public Transportation is Associated With Lower Prevalence of Excess Body Weight, Hypertension, and Diabetes
Authors: Hisako Tsuji, Ichiro Shiojima
Journal: Circulation (2015)

Background: Physical activity reduces body weight and incidence of diabetes mellitus (DM). We examined associations of commuting mode with prevalence of excess body weight, hypertension and DM. Methods: We studied 16,397 subjects who had the annual health checkup offered to adult citizens of Moriguchi city, Osaka, Japan in 2012. The subjects were asked about their work (Is your work physically active, sedentary or "cannot say"?) and commuting mode (walking or cycling / bus or train / car driving). Odds ratios (OR) of prevalence of excess body weight (body mass index &gt;25.0 kg/m 2 ), hypertension, and DM with 95% confidence intervals (CI) relative to the car driving group were calculated using logistic regression analyses adjusted for clinical variables. Results: There were 5,908 eligible workers. Characteristics of the subjects according to commuting mode are presented in the table. Compared to the car driving group, logistic regression analyses showed that the public transportation group had a significantly lower prevalence of excess body weight (OR=0.56, 95% CI=0.45 to 0.69, p&lt;0.0001) after adjustment for basic covariates (age, sex, smoking status, hypercholesterolemia, and physical activity of work) and hypertension, a significantly lower prevalence of hypertension (OR=0.73, 95% CI=0.59 to 0.90, p=0.0035) after adjustment for basic covariates and excess body weight, and a significantly lower prevalence of DM (OR=0.66, 95% CI=0.44 to 0.99, p=0.0427) after adjustment for basic covariates, hypertension, excess body weight, and family history of DM. Conclusions: The use of public transportation was associated with lower prevalence of excess body weight, hypertension, and DM.
Increasing Incidence of Low Birthweight— United States, 1981-1991
Journal: JAMA (1994)

A national health objective for the year 2000 is to reduce low birthweight (LBW) (< 2500 g [< 5 lbs, 8 oz]) to an incidence of no more than 5% of live-born infants (50.0 per 1000) (objective 14.5). During 1970-1985, the incidence of LBW in the United States declined steadily (2); however, from 1985 to 1991, the incidence increased slightly, from 67.5 to 71.2. In 1991, disorders relating to short gestation and LBW were the primary cause of death among black infants and the third leading cause among white infants. To characterize trends in the race-specific incidence of LBW by period of gestation from 1981 to 1991, data from birth certificates were analyzed. This report summarizes the results of that analysis.
The combination of elafibranor and semaglutide drastically improves fibrosing steatohepatitis and distinctly modulates liver inflammatory signature
Authors: Vanessa Legry, Philippe Poulain, Nicolas Stankovic Valentin, Peggy Parroche, Emeline Descamps, Carole Belanger, Dean Hum, Bart Staels, Stephen Harrison, Rohit Loomba, Arun Sanyal, Vlad Ratziu, Robert Walczak
Journal: Journal of Hepatology (2020)
PSEUDO-ICTERIC XNTHOSIS.
Authors: F. PRAKES WEBER
Journal: British Journal of Dermatology (1922)

Journal Article PSEUDO‐ICTERIC XNTHOSIS. Get access F. PRAKES WEBER, M.A., M.D., F.R.C.P.Lond. F. PRAKES WEBER, M.A., M.D., F.R.C.P.Lond. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 34, Issue 3, 1 March 1922, Pages 103–107, https://doi.org/10.1111/j.1365-2133.1922.tb11363.x Published: 01 March 1922
SOCIETY NEWS.
Authors: Thomas C. Smith
Journal: JAMA (1896)

<h3>Second Pan-American Medical Congress.</h3> —President Diaz will receive the Congress on the 19th inst., and the municipality of the City of Mexico will tender a reception on the 17th inst. Dr. H. L. E. Johnson, chairman transportation committee, has authorized the Baltimore &amp; Ohio road to communicate in his name with persons north and east desiring to attend the Congress and make arrangements over that road connecting with the special train of the American Tourist Association at Cincinnati. Dr. Liston H. Montgomery has arranged a special over the Laredo, Texas and Mexican National Railroad, at a cost of about $150. Stop-over privileges will be allowed, and the trip will occupy about three weeks. The price includes hotel accommodations. <h3>List of Honorary Presidents and Secretaries for Canada:</h3> — Drs. James Stewart, Montreal; H. P. Wright, Ottawa; John Caven, Toronto; L. D. Mignault, Montreal; Morehouse, London, Ont.; J. L. Davidson, Toronto; Sir
The Cover
Authors: Frederick Butzen
Journal: JAMA (1982)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Treatment patterns: Targeted therapies indicated for first-line management of metastatic renal cell carcinoma in a real-world setting.
Authors: Gregory P. Hess, Rohit Borker, Eileen Fonseca
Journal: Journal of Clinical Oncology (2012)

416 Background: Limited information about real-world treatment patterns of targeted agents for metastatic renal cell carcinoma (mRCC) is available to inform their use in clinical practice. Methods: This retrospective, observational study employed US claims data (January 2007-November 2010) to identify treatment patterns, including treatment duration and dosing, for targeted agents (sunitinib, sorafenib, pazopanib, bevacizumab, and temsirolimus) indicated in 1st line management of advanced/mRCC. The study included adult mRCC patients who were observed for ≥3 months after initiation of their 1st line therapy with a targeted agent. Descriptive analyses were conducted for the observed treatment patterns. Results: A total of 273 patients on 1st line therapy were identified and included in the study sample out of which 235 patients were treated with sunitinib, 16 patients with sorafenib, and 15 patients with temsirolimus. Pazopanib and bevacizumab were excluded from further analysis due to their small samples; n&lt;10. The median observed treatment durations were: sunitinib 3.3 months, sorafenib 4.0 months, and temsirolimus 2.6 months. Patients initiating therapy on sorafenib (n=16) and temsirolimus (n=15) in the study sample were insufficient for meaningful dosing analyses. In sum, of the n=235 sunitinib patients, 178 (approximately 76%) initiated therapy at the indicated dose of 50 mg. Sixty-five percent of these patients were not observed filling a 4th script (the average number observed), while 26% maintained their starting dose and 9% experienced a dose reduction at their fourth fill. (See table). Conclusions: This study suggests that opportunities exist to improve treatment duration in real-world clinical practice and to better understand possible influences, other than disease progression, on treatment and dose changes. [Table: see text]
Hypnoanesthesia in the morbidly obese
Authors: D. M. Morris
Journal: JAMA (1985)

The advent of chemical anesthesia relegated hypnosis to an adjunctive role in patients requiring major operations. Anesthesia can be utilized with acceptable risk in the great majority of patients encountered in modern practice. But an occasional patient will present—such as one with morbid obesity—who needs a surgical procedure and who cannot be safely managed by conventional anesthetic techniques. This report describes our experience with such a patient and illustrates some of the advantages and disadvantages of hypnoanesthesia. The greatest disadvantage is that it is unpredictable. Close cooperation between the patient, hypnotist, anesthesiologist, and surgeon is critical. However, the technique may be utilized to remove very large lesions in selected patients. Hypnoanesthesia is an important alternative for some patients who cannot and should not be managed with conventional anesthetic techniques. (<i>JAMA</i>1985;253:3292-3293)
CDK4/6 Inhibitors Impair Recovery from Cytotoxic Chemotherapy in Pancreatic Adenocarcinoma
Authors: Beatriz Salvador-Barbero, Mónica Alvarez-Fernández, Elisabet Zapatero-Solana, Aicha El Bakkali, María del Camino Menéndez, Pedro P. López-Casas, Tomas Di Domenico, Tao Xie, Todd VanArsdale, David J. Shields, Manuel Hidalgo, Marcos Malumbres
Journal: Cancer Cell (2020)
Partial deficiency of Thyroid transcription factor 1 produces predominantly neurological defects in humans and mice
Authors: Joachim Pohlenz, Alexandra Dumitrescu, Dorothee Zundel, Ursula Martiné, Winfried Schönberger, Eugene Koo, Roy E. Weiss, Ronald N. Cohen, Shioko Kimura, Samuel Refetoff
Journal: Journal of Clinical Investigation (2002)

Three genes, TTF1, TTF2, and PAX8, involved in thyroid gland development and migration have been identified. Yet systematic screening for defects in these genes in thyroid dysgenesis gave essentially negative results. In particular, no TTF1 gene defects were found in 76 individuals with thyroid dysgenesis even though a deletion of this gene in the mouse results in thyroid and lung agenesis and defective diencephalon. We report a 6-year-old boy with predominant dyskinesia, neonatal respiratory distress, and mild hyperthyrotropinemia. One allele of his TTF1 gene had a guanidine inserted into codon 86 producing a nonsense protein of 407, rather than 371, amino acids. The mutant TTF1 did not bind to its canonical cis-element or transactivate a reporter gene driven by the thyroglobulin promoter, a natural target of TTF1. Failure of the mutant TTF1 to interfere with binding and transactivation functions of the wild-type TTF1 suggested that the syndrome was caused by haploinsufficiency. This was confirmed in mice heterozygous for Ttf1 gene deletion, heretofore considered to be normal. Compared with wild-type littermates, Ttf1+/– mice had poor coordination and a significant elevation of serum thyrotropin. Therefore, haploinsufficiency of the TTF1 gene results in a predominantly neurological phenotype and secondary hyperthyrotropinemia.
Fifth Annual Report of the State Board of Health of Illinois.
Authors: None W.
Journal: JAMA (1884)

This report contains: Abstract of proceedings at the meetings during the year 1882; medical laws and institutions of the United States and Canada; smallpox epidemic, 1880-82; vaccination in Illinois; Proceedings of the Sanitary Council of the Mississippi Valley; mortality statistics, and many other matters collateral to these general topics. Several minor points are worthy of note. In this report the value of the immigrant inspection service of the National Board of Health is clearly demonstrated. The questions used for the examination of candidates for licenses by the State Board, Clearly show the impropriety of such examinations being conducted by other than practical teachers in medical science. In justification of this criticism we quote the following: What chemical elements are contained in pure grape sugar not found in cane sugar? A catch question and not justifiable in an examination. Give the therapeutic uses and applications of aqua<i>fluvialis</i>or<i>fontana?</i>These
Cutting Cholera Cases
Authors: Joan Stephenson
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
10-minute consultation: Chronic cough
Authors: G. P Currie
Journal: BMJ (2003)

OBJECTIVE: To measure total energy expenditure and body composition in small for gestational age (SGA) infants, to investigate hypermetabolism. METHODS: A cross-sectional study was performed in 52 small for gestational age (SGA) measured at 5 weeks of age, using existing data from appropriate for gestational age (AGA) infants as controls. The doubly-labelled water technique was used to assess both total energy expenditure and body composition in both cohorts of infants. RESULTS: Multiple regression analysis revealed that expressing energy expenditure per kg fat free mass adjusts for body composition in infants of this age. Regression analysis also showed that the relation between total energy expenditure and fat free mass differed between the two groups. CONCLUSION: These data indicate that for a given fat free mass, the total energy expenditure of SGA infants is greater than that of AGA infants. Such data should be taken into account when energy requirements for SGA infants are being considered.
Endpiece: Prejudices
Authors: A. Einstein
Journal: BMJ (1999)

trials available for analysis the reduction in acute rejection shown in our study may be an overestimate of the true treatment effect of tacrolimus.Another limitation of this analysis was the exclusion of newer immunosuppressive agents.In the four included studies, Sandimmun (original cyclosporin formulation) rather than Neoral (new microemulsion formulation of cyclosporin) was used.Because of its improved bioavailability, Neoral has now replaced Sandimmun at most transplant centres.Also, mycophenolate mofetil in combination with cyclosporin has been shown significantly to decrease episodes of acute rejection. 27Accordingly, our metaanalysis cannot provide recommendations concerning the concomitant use of these novel drugs in renal transplantation. ConclusionsThis meta-analysis of randomised trials has shown that after renal transplantation tacrolimus based immunosuppression is associated with a significant reduction in acute rejection, a significant reduction in use of antilymphocyte antibodies, and a significant increase in the prevalence of post-transplant diabetes mellitus at 1 year compared with cyclosporin.Future studies should evaluate the use of tacrolimus along with newer immunosuppressive drugs as well as its use in high risk groups that could not be assessed in this analysis.These might include patients who are highly sensitised, African-Americans, or recipients of repeat transplants.In addition, future trials should strive to improve methodological quality-for example, double blinding and adequate randomisation-to produce more reliable estimates of treatment effect.Finally, outcome studies with longer follow up are needed to see if the early reduction in acute rejection translates into improved long term graft survival.
Depression, anxiety and world assumptions amongst cancer patients
Authors: L. Pishniak, A. Ashkenazi, D. Sadeh-Tassa, Y. Yagil, A. Figer
Journal: Journal of Clinical Oncology (2004)

8197 Background: The term 'World assumptions' (WA) refers to beliefs by which one defines his/her own identity and coping strategies. Psychologists have been interested in the association between depression, anxiety and WA. It was even suggested that anxiety and depression can be treated by mainly focusing on altering dysfunctional beliefs. The aim of the current study was to investigate which beliefs are associated with anxiety and depression amongst cancer patients. Methods: We conducted a convenience sampling with 69 female breast cancer patients, and 68 colorectal cancer patients (33 males, 35 females), aged 35–85, treated in 3 urban medical centers in Israel. Measurements were made using the world assumptions scale and the brief symptoms index. Results: In our sample, anxiety and depression were both found to be significantly more severe among breast cancer patients than in colorectal patients. Breast cancer patients also reported more dysfunctional world assumptions. A Pearson correlation procedure showed a significant association between some of the world assumptions and anxiety and depression. Conclusions: Since we conducted an uncontrolled field study, our findings can be explained in several ways. For examle, participants in our study were treated in distinct medical settings. This can account for at least some of the differences we found. Still, our results indicate that breast cancer patients are more prone to suffer from psychological distress, in addition or as a result of their disease. We also found that negative or rigid world assumptions, expressed by cancer patients in a regular medical examination, need to be perceived by health professionals as a possible indication for an underlying psychological distress. Finally, since some of the WA were associated with depression and anxiety, brief cognitive psychotherapy can be tested for achieving rapid psychological relief. No significant financial relationships to disclose.