tbuckley/cabot-search huggingface dataset:
Myelodysplastic syndrome and acute nonlymphocytic leukemia secondary to mitolactol treatment in patients with breast cancer.
Authors: G Falkson, R S Gelman, R Dreicer, D C Tormey, A S Alberts, M A Coccia-Portugal, D Rushing, J M Bennett
Journal: Journal of Clinical Oncology (1989)

One thousand four hundred sixty patients with 2,590 patient-years of follow-up were treated on 15 protocols for metastatic breast cancer with dibromodulcitol (mitolactol; DBD)-containing regimens since 1976. Twenty-three patients developed myelodysplastic syndrome (MDS) and/or acute nonlymphocytic leukemia (ANLL). The overall risk of developing MDS or ANLL per person is 1.6%. In patients who had received more than 16,000 mg of DBD the risk per person is 6%, and in the high-dose subsets of patients who received no prior radiation or alkylator therapy, it is 7.9%. The risk per person increases to a maximum by 30 to 36 months (5.3%). The high risk was seen despite a study population of metastatic breast cancer patients with a median survival of 16 months. This analysis strongly suggests that DBD is one of the most potent of the reported leukemogenic-inducing agents. Further use of this drug in both the adjuvant and metastatic situation should be reconsidered.
Correction to: Effect of High-Intensity Interval Training in De Novo Heart Transplant Recipients in Scandinavia: One-Year Follow-Up of the HITTS Randomized, Controlled Study
Journal: Circulation (2019)

a correction to the supplemental file is needed.The online-only Data Supplement Table VII needed 2 corrections: 1.The negative coefficient (-0.77) for O 2 pulse was incorrect because the postvalue was mistakenly subtracted from the pre-value.The standardized coefficient (beta) for O 2 pulse should be 0.77.2. All the confidence intervals were incorrect, they corresponded to the unstandardized B and not the standardized beta values.Correct confidence intervals are now given.
The Public Health and Economic Benefits of Taxing Sugar-Sweetened Beverages
Authors: Tamara Rios
Journal: New England Journal of Medicine (2010)

In the second sentence of the third paragraph (page 77), "generate and secrete large amounts" should have read "generate large amounts."In Figure 1 (page 78), "Asparagine synthetase secreted" should have read "Asparagine secreted," and the first sentence of the figure legend should mention "asparagine" rather than "asparagine synthetase."The article has been corrected at NEJM.org.Antibiotic Prophylaxis and Recurrent Urinary Tract Infection in Children (October 29, 2009;361:1748-59).In Table 2 (page 1756), under "Renal scan at 1 yr," the words "at baseline" should not have followed "Normal results" and "Abnormal results."Under "Normal results" and "Abnormal results," the words "as compared with baseline" should follow "Unchanged" (two instances), "Resolved," "Improved," and "Worse."We regret the error.The article has been corrected at NEJM.org.
Libri
Authors: Egon Plesch, N.N. Dracoulides, S. Lebovici, P. Paumelle, Hans A. Illing, S. Biran, S.R. Slavson
Journal: Psychotherapy and Psychosomatics (1962)

8o L ibrix. Etude psychologique et sociologique de la femme en rapport avec la gros sesse, l'accouchement et la période post-partum.2. Psycho-physiologie de la douleur de l'accouchement.3. Théorie pratique et résultats de la préparation psychosomatique de l'ac couchement.4. Valeur et limites des méthodes psychosomatiques en obstétrique.5. En dehors de ces thèmes une journée sera consacrée aux communications libres sur des sujets de psychosomatique obstétricale.
Damage to Cervical Region of Spinal Cord After Roentgen-Ray Therapy
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mechanisms of Progesterone Receptor Inhibition of Inflammatory Responses in Cellular Models of Breast Cancer
Authors: Sakiko Kobayashi, James P. Stice, Dmitri Kazmin, Bryan M. Wittmann, Erin A. Kimbrel, Dean P. Edwards, Ching-Yi Chang, Donald. P. McDonnell
Journal: Endocrine Reviews (2010)

Both pro- and antimitogenic activities have been ascribed to progesterone receptor (PR) agonists and antagonists in breast cancer cells; however, the transcriptional responses that underlie these paradoxical functions are not apparent. Using nontransformed, normal human mammary epithelial cells engineered to express PR and standard microarray technology, we defined 2370 genes that were significantly regulated by the PR agonist R5020. Gene ontology (GO) analysis revealed that GO terms involved in inflammation and NF-κB signaling were among the most significantly regulated. Interestingly, on those NF-κB responsive genes that were inhibited by agonist-activated PR, antagonists either 1) mimicked the actions of agonists or 2) reversed the inhibitory actions of agonists. This difference in pharmacological response could be attributed to the fact that although agonist- and antagonist-activated PR is recruited to the promoters of NF-κB-responsive promoters, the physical presence of PR tethered to the promoter of some genes is sufficient for transcriptional inhibition, whereas on others, an agonist-activated PR conformation is required for inhibition of NF-κB signaling. Importantly, the actions of PR on the latter class of genes were reversed by an AF-2-inhibiting, LXXLL-containing peptide. Consideration of the relative activities of these distinct antiinflammatory pathways in breast cancer may be instructive with respect to the likely therapeutic activity of PR agonists or antagonists in the treatment of breast cancer.
Cytembena*
Journal: Environmental Health Perspectives (1982)

because preliminary clinical results from Czechoslovakia indicated that this chemical might have use as a cytostatic agent (1-4).Clinical trials in the United States were discontinued because no apparent antineoplastic effects were seen (5-7). MethodsMale and female inbred Fischer 344 rats and male and female hybrid B6C3F1 mice, obtained from Frederick Cancer Research Center, were used in this study.Control and treated groups comprised 50 animals of each species and sex.For 104 consec- utive weeks all groups were fed Wayne Lab Blox.Three times per week treated groups were given intraperitoneal injections of 7 or 14 mg/kg (for rats) and 12 or 24 mg/kg (for mice) of cytembena (99.4% pure).Control groups received 0.9% saline injections.This carcinogenesis bioassay was conducted dur- ing January
Inhibition by perhexiline of oxidative phosphorylation and the β-oxidation of fatty acids: Possible role in pseudoalcoholic liver lesions
Authors: D Deschamps
Journal: Hepatology (1994)

In an attempt to better understand the mechanisms for pseudoalcoholic liver lesions in human beings, we determined the effects of perhexiline on mitochondrial functions in mice and rats. A first series of studies suggested that protonated perhexiline entered mouse mitochondria along the mitochondrial membrane potential. Release of a proton in the mitochondrial matrix led to uncoupling of oxidative phosphorylation, and accumulation of perhexiline inhibited complexes I and II of the respiratory chain, decreased ATP formation in vitro and decreased the mitochondrial β-oxidation of long-, medium- and short-chain fatty acids in vitro and in vivo in mice. In cultured rat hepatocytes, exposure for 24 hr to 25 μmol/L perhexiline markedly decreased hepatocellular ATP and cell viability. Exposure to 5 μmol/L perhexiline did not modify ATP and viability but decreased the β-oxidation of palmitic acid uniformly labeled with carbon 14 by 38%, increased hepatocyte triglyceride levels by 98% and produced microvesicular steatosis after 72 hr of culture. We conclude that perhexiline is concentrated inside mitochondria, where it inhibits both oxidative phosphorylation and the mitochondrial β-oxidation of fatty acids. These effects may contribute to the development of necrosis, steatosis and possibly certain other pseudoalcoholic liver lesions in human beings. (HEPATOLOGY 1994;19:948–961.)
Dose-related effects of cigarette smoking on olfactory function
Authors: R. E. Frye
Journal: JAMA (1990)

Little is known about the influence of cigarette smoking on the ability to smell; previous studies on this topic have led to contradictory findings and have failed to take into account smoking dose and duration. In the present study, the 40-odorant University of Pennsylvania Smell Identification Test was administered to 638 subjects for whom detailed smoking histories were available. Smoking was found to be adversely associated with odor identification ability in a dose-related manner in both current and previous cigarette smokers. Among previous smokers, improvement in olfactory function was related to the time elapsed since the cessation of smoking. Logistic regression analysis found current smokers to be nearly twice as likely to evidence an olfactory deficit than persons who have never smoked. Overall, the data suggest that (1) smoking causes long-term but reversible adverse effects on the ability to smell and (2) the failure of some studies to demonstrate smoking effects may be caused by the inclusion of persons with a history of smoking in the nonsmoking groups. (<i>JAMA</i>. 1990;263:1233-1236)
A Comparison of Aspirin plus Tirofiban with Aspirin plus Heparin for Unstable Angina
Authors: The Platelet Receptor Inhibition in Ischemic Syndrome Management (PRISM) Study Investigators
Journal: New England Journal of Medicine (1998)

Activation of platelets is central to the pathophysiology of unstable angina. We studied whether inhibition of the final common pathway for platelet aggregation with tirofiban, a nonpeptide glycoprotein IIb/IIIa receptor antagonist, would improve clinical outcome in this condition.In a double-blind study, we randomly assigned 3232 patients who were already receiving aspirin to additional treatment with intravenous tirofiban for 48 hours. The primary end point was a composite of death, myocardial infarction, or refractory ischemia at 48 hours.The incidence of the composite end point was 32 percent lower at 48 hours in the group that received tirofiban (3.8 percent, vs. 5.6 percent with heparin; risk ratio, 0.67; 95 percent confidence interval, 0.48 to 0.92; P=0.01). Percutaneous revascularization was performed in 1.9 percent of the patients during the first 48 hours. At 30 days, the frequency of the composite end point (with the addition of readmission for unstable angina) was similar in the two groups (15.9 percent in the tirofiban group vs. 17.1 percent in the heparin group, P=0.34). There was a trend toward a reduction in the rate of death or myocardial infarction with tirofiban (a rate of 5.8 percent, as compared with 7.1 percent in the heparin group; risk ratio, 0.80; 95 percent confidence interval, 0.61 to 1.05; P=0.11), and mortality was 2.3 percent, as compared with 3.6 percent in the heparin group (P=0.02). Major bleeding occurred in 0.4 percent of the patients in both groups. Reversible thrombocytopenia occurred more frequently with tirofiban than with heparin (1.1 percent vs. 0.4 percent, P=0.04).Tirofiban was generally well tolerated and, as compared with heparin, reduced ischemic events during the 48-hour infusion period, during which revascularization procedures were not performed. The incidence of refractory ischemia and myocardial infarction was not reduced at 30 days, but mortality was lower among the patients given tirofiban. Platelet inhibition with aspirin plus tirofiban may have a role in the management of unstable angina.
Abstract 431: Upregulation of Small Conductance Ca <sup>2+</sup> Activated K <sup>+</sup> Channels Promotes Formation of Mitochondrial Supercomplexes and Increases Respiration Reserve
Authors: Shanna Hamilton, Radmila Terentyeva, Karim Roder, Iuliia Polina, Gideon Koren, Richard T Clements, Dmitry Terentyev
Journal: Circulation Research (2017)

Introduction: Small conductance calcium (Ca 2+ )-activated K + (SK) channels are present in the inner mitochondria membrane of ventricular cardiomyocytes. We recently reported that pharmacological enhancement of mito-SKs protects from Ca 2+ dependent arrhythmia by reducing production of reactive oxygen species (ROS) by mitochondria thereby normalizing oxidation state and activity of Ca 2+ release channels ryanodine receptors in hypertrophic rat hearts. Recent advances demonstrate that respiratory components of the mitochondrial electron transport chain can organize into supercomplexes (SCs) resulting in more efficient electron transfer and reduced generation of ROS. Hypothesis: Functional upregulation of mito-SK channels protects from Ca 2+ -dependent arrhythmia via promotion of mitochondrial SC formation and improved respiration. Methods: H9C2 myoblasts were infected with adenoviral vectors to overexpress SK2 and Cox7rp. After 48 hours in culture, cell respiration was measured using Seahorse XFe Analyzer; ROS was measured using general ROS indicator CFDA; and mitochondria were isolated to assess SC formation using Blue-Native electrophoresis (BN-PAGE). The effects of SK enhancer NS309 (2 μM, 10 min.) on SC formation were studied in Langendorff perfused rat hearts with hypertrophy induced by thoracic aortic banding (TAB). Results: rSK2 overexpression in H9C2s reduced intracellular ROS ~ 30%, enhanced maximum respiration rate vs. controls (0.74±0.04 and 0.58±0.03 pM/min/μg respectively, p&lt;0.05); and caused a robust shift (&gt;2 fold) of complex IV towards large mitochondrial SCs (~1.2 mDa). As a control, similar results were obtained with overexpression of Cox7rp protein that promotes SC formation. In addition, BN-PAGE experiments in isolated rat hearts demonstrated that robust decrease in high MW Complexes I and IV in hypertrophy was fully restored to control levels upon treatment with SK enhancer NS309. Conclusion: Upregulation of SK channels reduces mito-ROS by an increase in respiration reserve which is linked to enhanced mitochondrial SC formation. Our data suggest that targeting mito-SK channels has therapeutic potential to treat cardiac arrhythmia in conditions accompanied by oxidative stress.
AIR CONDITIONING FOR PREMATURE INFANTS
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Disruption of a mitral-valve prosthesis. A complication associated with closed-chest cardiac massage
Authors: B. R. Wilcox
Journal: JAMA (1965)

EXTERNAL CARDIAC MASSAGE has wide application in the treatment of cardiac arrest. Though complications have been reported to accompany this maneuver,<sup>1-4</sup>it is unquestionably a valuable resuscitative measure. Nevertheless, the case reported below suggests there are certain situations where closed-chest cardiac massage might well be hazardous. <h3>Report of a Case</h3> A 22-year-old mentally retarded woman was first admitted to North Carolina Memorial Hospital in 1955 with the diagnosis of rheumatic heart disease, mitral-valve insufficiency, and subacute bacterial endocarditis secondary to infection with α-hemolytic streptococci. At that time, her electrocardiogram showed frequent premature ventricular contractions with runs of bigeminal rhythm. She responded well to therapy and was discharged on a regimen of prophylactic penicillin and digitalis. Her second admission was in 1961 for sterilization by abdominal hysterectomy. Her preoperative and postoperative course was complicated by ventricular arrhythmia, necessitating a prolonged hospitalization. In April 1962, prior to her third admission, she
Increased Prevalence of Significant Coronary Artery Calcification in Patients With Diabetes
Authors: Sunita Schurgin, Stuart Rich, Theodore Mazzone
Journal: Diabetes Care (2001)

OBJECTIVE— Coronary artery disease is the major cause of morbidity and mortality in patients with diabetes. Detection of coronary artery disease before the first myocardial infarction and before anginal symptoms will allow for strategies designed to reduce the cardiovascular event rate in this group of patients. Electron beam—computed tomography (EBCT)is a noninvasive technology for evaluating the extent of coronary artery atherosclerosis that relies on the detection of coronary artery calcium (CAC). We used EBCT to detect significant coronary artery atherosclerosis in diabetic patients without symptoms of heart disease. RESEARCH DESIGN AND METHODS— We used EBCT to evaluate calcium in the coronary arteries of 139 consecutive diabetic patients scanned over a 20-month period. The CAC scores in this group were compared with a randomly selected nondiabetic control group and a control group that was selected to match a number of established cardiovascular risk factors. RESULTS— Patients with diabetes had a significant increase in the prevalence of CAC scores ≥400 (25.9%) compared with the randomly selected (7.2%) and matched (14.4%) nondiabetic control groups. Scores in this range have been reported to be highly predictive for abnormal stress myocardial perfusion tomography and subsequent coronary events. CONCLUSIONS— Our results, therefore, indicate a substantial prevalence of significant coronary artery disease in an asymptomatic diabetic patient population compared with non-diabetic control subjects. They also suggest that EBCT may be a useful approach for selecting a group of diabetic subjects who would benefit most from additional evaluation for subclinical coronary artery disease.
Influence of Social Factors on Lead Exposure and Child Development
Authors: Robert L. Bornschein
Journal: Environmental Health Perspectives (1985)

A brief overview of current views of child development is provided, with particular attention given to the role the child's physical and social environment plays in influencing the developmental process. Examples from the recent literature are used to illustrate how these factors can influence lead exposure and most importantly how they might interact with lead to ameliorate or exacerbate possible lead effects. An example is provided which demonstrates that failure to control adequately and to adjust the data statistically to correct for the influence of these factors can lead one erroneously to attribute cognitive and behavioral changes to lead. Finally, data from the Cincinnati Prospective Lead Study are presented to illustrate the application of structural equation modeling as a means for unraveling the complex web of sociodemographic, environmental and behavioral influences on childhood lead exposure. The latter analysis indicates that for children less than 24 months of age, lead-containing dust in the home and on the children's hands are important determinates of their blood lead levels. This relationship is influenced by the amount of maternal involvement with their child and other indices of interaction between the child and primary caregiver.
Descriptive epidemiology of primary brain and CNS tumors: Results from the Central Brain Tumor Registry of the United States, 1990–1994
Authors: Tanya S. Surawicz, Bridget J. McCarthy, Varant Kupelian, Patti J. Jukich, Janet M. Bruner, Faith G. Davis
Journal: Neuro-Oncology (1999)

The Central Brain Tumor Registry of the United States (CBTRUS) obtained 5 years of incidence data (1990-1994)-including reports on all primary brain and CNS tumors-from 11 collaborating state cancer registries.Data were available for 20,765 tumors located in the brain, meninges, and other CNS sites, including the pituitary and pineal glands.The average annual incidence was estimated at 11.5 cases per 100,000 person-years.The higher incidence of tumors in male patients (12.1 per 100,000 person-years) than in female patients (11.0 per 100,000 person-years) was statistically signi cant (P<0.05); the higher incidence in whites (11.6 per 100,000 person-years) compared with blacks (7.8 per 100,000 person-years) was statistically signi cant (P<0.05).The most frequently reported histologies were meningiomas (24.0%) and glioblastomas (22.6%).Higher rates for glioblastomas, anaplastic astrocytomas, oligoden-drogliomas, anaplastic oligodendrogliomas, ependymomas, mixed gliomas, astrocytomas not otherwise speci ed, medulloblastomas, lymphomas, and germ cell tumors in male than in female patients were statistically signi cant (P<0.05), with relative risks (RR) ranging from 1.3 to 3.4.Meningiomas were the only tumors with a signi cant excess in females (RR=0.5).We noted higher occurrence rates in whites than in blacks for the following histologies: diffuse astrocytomas, anaplastic astrocytomas, glioblastomas, oligodendrogliomas, ependymomas, mixed gliomas, astrocytomas NOS, medulloblastomas, nerve sheath tumors, hemangioblastomas, and germ cell tumors, with RRs ranging from 1.5 to 3.4.Racial differences in occurrence rates were not observed for predominately benign meningiomas or pituitary tumors.This study represents the largest compilation of data on primary brain and CNS tumors in the United States.Standard reporting de nitions and practices must be universally adopted to improve the quality and use of cancer registry data.