tbuckley/cabot-search huggingface dataset:
Combination chemotherapy with docetaxel and gemcitabine in anthracycline pretreated patients with metastatic breast cancer (MBC)
Authors: P. H. Slee, R. S. De Jong, A. Honkoop, C. Rodenburg, S. Eelkman Rooda, J. Coenen, P. C. De Jong, J. Douma
Journal: Journal of Clinical Oncology (2004)

792 Background: There is a need for more effective 2nd line treatment options for MBC. Both docetaxel (D) and gemcitabine (G) have shown efficacy in MBC as single agents. Combination-chemotherapy, even in 2nd line, may have advantages over single agent therapy. Methods: This multicenter phase II study evaluated the efficacy and safety of D and G in patients with anthracycline pretreated MBC. Eligibility criteria included measurable disease, adequate performance status and organ- and hematological functions. Patients received i.v. G 1000 mg/m2 d1 and d8 and on day 8 immediately followed by D 75 mg/m2 every 3 weeks for 6 cycles up to a maximum of 9 cycles. Premedication for D consisted of oral dexamethason 16 mg for 3 days starting the day before D infusion. Response evaluation was performed every 3rd cycle. Results: 34/40 pts have been enrolled, 26 are evaluable for response and toxicity. Anthracycline pretreatment was given for adjuvant purposes (10/26) or for palliative purposes (16/26 patients). This last group received 2nd line palliative chemotherapy. 21/26 Received at least 6 cycles, treatment was discontinued prior to 6 cycles due to progressive disease (PD) in 3/26. Two complete responses and 14 partial responses were observed, leading to an overall response rate of 61% (16/26). Stable disease was observed in 7 patients and 3 patients had PD. The mean response duration was 6.1 months. Mean time to progression was 7.7 months. Hematological toxicity was modest with grade 3–4 (NCI-CTC) leucopenia in 23/184 cycles, febrile leucopenia (grade 3) in 1/184 cycles and grade 3–4 thrombocytopenia in 2/184 cycles. Non-hematological toxicity(grade 3/4): edema 2/184 and diarrhea 1/184 cycles. Conclusions: Combination chemotherapy with gemcitabine 1000 mg/m2 d1 and d8 and docetaxel 75 mg/m2 on d 8 is feasible in anthracycline pretreated MBC and shows promising efficacy. No significant financial relationships to disclose.
Bone marrow transplantation, ulcerative colitis, and acquired immunodeficiency syndrome (AIDS)
Authors: A. S. Spiers
Journal: JAMA (1987)

<h3>To the Editor.—</h3> It is universally recognized that bone marrow transplantation from an allogeneic donor is followed by severe and frequently prolonged acquired immune deficiency.<sup>1,2</sup>Many clinical and immunologic features of the syndrome resemble those of acquired immunodeficiency syndrome (AIDS), including reversal of the T4/T8 lymphocyte ratio.<sup>3</sup>Because of these similarities and because recipients of marrow transplants also receive multiple transfusions of red blood cells and platelets, Atkinson and coworkers<sup>4</sup>examined serum samples from 17 marrow transplant recipients for antibody to human T-cell lymphotropic virus type III (human immunodeficiency virus). Of the 16 patients who were seronegative, eight had severe infections, and it was concluded that the immune deficiency after marrow transplantation is not caused by an AIDS-associated retrovirus. A group in Paris,<sup>5</sup>while in basic agreement with this view, has demonstrated antibody to the AIDS virus in 4% of marrow recipients before transplantation and in
Über cerebrale Zirkulationsstörungen: Tierexperimentelle Untersuchungen über Mikroembolien, Schädigungen der Gefässpermeabilität und Blutungen verschiedener Art
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Biochemical response to tissue injury
Authors: H. T. Randall
Journal: JAMA (1967)

The biochemical response to tissue injury can be considered a combination of the local events occurring within the area of injury and the systemic response induced by the local injury through humoral and neuroendocrine pathways. Tissue injury is an inevitable component of the process of living. Acute episodes of infection, infarction, external trauma, or elective or emergency surgery are common events. Survival depends upon the ability to handle both the local injury and the complex chain of responses set into motion by it. Surgeons accept the responsibility for the care of most patients suffering from accidental tissue injury and many types of infection and vascular occlusion. In addition, surgery creates, of necessity, injury to a wide spectrum of body tissues. Surgeons must have an extensive practical knowledge of both local tissue response, and of the complex of systemic reactions that patients undergo when injured. Preoperative preparation, intraoperative monitoring and support,
This Week in &lt;emph&gt;JAMA&lt;/emph&gt;
Journal: JAMA (2009)

A Piece of My Mind"Statistics show that postmenopausal women die at a much higher rate than premenopausal women, so why not go with a winner?"From "The Women's and Children's HMO." SEE PAGE 1320 Medical News & PerspectivesGrowing evidence suggests that Hispanic women are more likely than white or black women to have inherited forms of breast cancer that are aggressive and often affect women at a relatively young age.
Primary Cardiology
Authors: Robert E. Rakel
Journal: Annals of Internal Medicine (1999)

Medical Writings: Book Notes2 February 1999Primary CardiologyRobert E. Rakel, MDRobert E. Rakel, MDBaylor College of Medicine, Houston, Texas.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-130-3-199902020-00040 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Goldman L, Braunwald E. 526 pages. Philadelphia: WB Saunders; 1998. $60.00. ISBN 0721664024. Order phone 800-545-2522.Field of medicine: Cardiology.Format: Hardcover book.Audience: Primary care physicians and other noncardiologists.Purpose: To provide primary care physicians with an authoritative, user-friendly text that is more in-depth than manuals but not as extensive as traditional cardiology textbooks.Content: The book focuses on the fundamental principles that underlie evidence-based medicine and the evaluation and management of cardiovascular problems frequently encountered in primary care. Chapters 1 through 6 cover clinical decision making, clinical examination, and screening for coronary artery disease. Chapters 7 through 16 ... Author, Article, and Disclosure InformationAffiliations: Baylor College of Medicine, Houston, Texas. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 2 February 1999Volume 130, Issue 3Page: 251KeywordsCardiovascular diseasesCardiovascular therapyComputer softwareDecision makingElectrocardiographyEvidence based medicineHeart failurePrimary care physiciansStable coronary artery diseaseUnstable angina ePublished: 15 August 2000 Issue Published: 2 February 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
PECUNIARY VALUE OF A WOMAN'S LIFE.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Legislation expands federal role in medical technology assessment
Journal: JAMA (1984)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Money and Medical Schools
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cytokines as mediators of autoimmune diabetes and diabetic complications
Authors: O. G. Pankewycz
Journal: Endocrine Reviews (1995)

Journal Article Cytokines as Mediators of Autoimmune Diabetes and Diabetic Complications Get access Oleh G. Pankewycz, Oleh G. Pankewycz 1Department of Medicine, University of Virginia Charlottesville, Virginia, 22908 *Address requests for reprints to: Oleh G. Pankewycz, M.D., Renal Division, Department of Medicine, Box 133, Health Sciences Center, University of Virginia, Charlottesville, Virginia 22908. Search for other works by this author on: Oxford Academic Google Scholar Jing-Xin Guan, Jing-Xin Guan 1Department of Medicine, University of Virginia Charlottesville, Virginia, 22908 Search for other works by this author on: Oxford Academic Google Scholar John F. Benedict John F. Benedict 1Department of Medicine, University of Virginia Charlottesville, Virginia, 22908 Search for other works by this author on: Oxford Academic Google Scholar Endocrine Reviews, Volume 16, Issue 2, 1 April 1995, Pages 164–176, https://doi.org/10.1210/edrv-16-2-164 Published: 01 April 1995
Hachich: Herbe de folie et de rêve
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
<i>Gerichtliche Psycho-pathologie (Forensic Psycho-pathology)</i>bear beitet von Dr. L. Schlager, Prof. in Wien, Dr. H. Emminghaus, Prof. in Dorpat. Dr. L. Kirn, Decent. in Freiburg i. B. Dr. M. Gauster, Sanitätsrath in Wien. Dr. R. v. Krayft-Ebing, Prof. in Graz. Tübingen, 1882. (Vol. IV of I. Maschka's Handbook of Forensic Medicine.)
Authors: D.,
Journal: American Journal of Psychiatry (1884)
Long-term hemodialysis and supraclavicular bruits. A method of examination
Authors: S. D. Wheeler
Journal: JAMA (1982)

CERVICAL venous hums have been reported in 87.5% of patients examined while undergoing dialysis.<sup>1</sup>Others have described supraclavicular and carotid bruits in 72% to 93.3% of hemodialysis patients when examined between dialyses.<sup>2,3</sup>Duncan et al<sup>2</sup>performed periorbital Doppler studies on hemodialysis patients and found that in "no patient was a carotid bruit heard along the carotid arteries without a louder bruit of similar characteristics more proximally"; none had an abnormal periorbital Doppler study result. It has been suggested that these sounds may be the result of a hyperkinetic vascular state and are benign. Unfortunately, no clinical maneuver has been described that clearly distinguishes genuine carotid bruits from the transmitted supraclavicular bruits heard in hemodialysis patients. However, the following case suggested a method that was helpful in making this differentiation. To test the validity of this simple technique, neurovascular examinations were performed for 40 patients with arteriovenous fistulae
Endoscopy
Authors: Edward B. Benedict
Journal: New England Journal of Medicine (1953)

Esophagoscopy Indications Desforges, Aves and Strieder58 believe that esophagoscopy is indicated in some cases of esophagogastrointestinal hemorrhage. The patients described by these authors were bleeding from some type of upper esophagogastrointestinal lesion at the time of esophagoscopy. Barium examination could not be carried out in many of these patients because of their moribund condition. However, x-ray examination during recent, previous admissions had indicated the presence of varices in only 2 of the 6 patients in whom varices were demonstrable by esophagoscopy. The exclusion of esophageal varices or bleeding from eroded areas in a hiatus hernia will go far toward establishing . . .
Differential Regulation of Plasma Obestatin and Ghrelin by Meal Intake and the Cholinergic System in Lean, But Not Obese Individuals
Authors: Christina Maier, Michaela Riedl, Greisa Vila, Michael Wolzt, Martin Clodi, Bernhard Ludvik, Anton Luger
Journal: Endocrine Reviews (2010)

Context:Obestatin is cosecreted with and stemming from the same precursor as ghrelin and is apparently involved in energy metabolism. Relatively little is known about the regulation of obestatin release.
Prognostic Significance of Cytokeratin-20 Reverse Transcriptase Polymerase Chain Reaction in Lymph Nodes of Node-Negative Colorectal Cancer Patients
Authors: Robert Rosenberg, Axel Hoos, James Mueller, Patricia Baier, Dominik Stricker, Martin Werner, Hjalmar Nekarda, Jörg-Rüdiger Siewert
Journal: Journal of Clinical Oncology (2002)

Approximately 20% to 30% of patients with curatively resected, node-negative (pN0) colorectal cancer die of tumor recurrence, which can be caused by minimal residual disease. To identify patients with an increased risk of tumor recurrence and evaluate the prognostic value of cytokeratin-20 (CK-20), we detected CK-20-positive cells in histopathologically tumor-free lymph nodes (pN0) of patients with colorectal cancer.Two peritumoral lymph nodes each from 85 patients with completely resected (R0) colorectal cancer without lymph node metastases (pN0) by routine examination were analyzed using a CK-20-specific reverse transcriptase polymerase chain reaction (RT-PCR) and compared with CK-20-specific immunohistochemistry (IHC). The results were correlated with histopathologic findings and with survival.CK-20 RT-PCR was positive in 44 patients (52%) and detected 83% of cancer-related death. Positive RT-PCR was significantly correlated with poorer overall survival (P <.009). Comparing RT-PCR with IHC, 13 patients with positive RT-PCR were identified, where the CK-20 expression was caused by tumor cell contamination located exclusively outside the lymph node capsule and had no prognostic impact. Defining these 13 patients as RT-PCR negative improved specificity of the RT-PCR assay from 57% to 75%. The 5-year overall survival of the 31 RT-PCR-positive patients was 71%, compared with 96% in the 54 negative patients (P <.001). Multivariate analysis showed expression of CK-20 mRNA to be an independent prognostic factor with a relative risk of cancer-related death of 6.1.CK-20 RT-PCR in peritumoral histopathologic tumor-free (pN0) lymph nodes of colorectal cancer is an independent prognostic factor for overall survival. Additional CK-20 IHC improves the specificity and prognostic value of RT-PCR for cancer-related death.
DISEASES AND HOSPITALS OF AFRICA.
Authors: NICHOLAS SENN
Journal: JAMA (1906)

<h3>THE HOSPITALS OF PRETORIA AND CAPE TOWN.</h3> Pretoria, the former proud capital of the republic of South Africa, is only two hours distant from Johannesburg by rail. There is nothing to be seen here which would remind one of the terrible struggle which the brave Boers made in defending their rights and in maintaining their independence. Their leader, the late President Kruger, sleeps now in the little cemetery, surrounded by members of his family, who preceded him in death, and blue violets are blooming on his grave, symbolic of the purity of his private and public life. The city remains the same as before the war, but the magnificent public buildings, built and paid for by the Boers, are now in possession of the new administration. The Boers, a law-abiding people, have accepted their defeat in humility. Their worldy losses will be repaired in course of time, but the wounds
Pulmonary Hypertension
Authors: John L. Zeller, Denise M. Goodman, Cassio Lynm, Edward H. Livingston
Journal: JAMA (2012)

Right ventricleLeft ventricle From lower body To lower bodyTo lun g To lu ng F ro m lu n g F r o m lu n g From upper bodyTo upper body Healthy pulmonary arterial vessel Pulmonary hypertensionB lood leaves the heart through a large blood vessel called the pulmonary artery.It flows through the lungs, absorbing oxygen, and then returns to the heart to be pumped through another large vessel, the aorta, to the body.Just as a person has a normal blood pressure for the body, he or she also has a normal blood pressure for the blood passing through the lungs.In a person with pulmonary hypertension, the pressure becomes abnormally elevated.This happens because the small arteries in the lung become abnormally narrow.As a consequence, blood cannot pass easily through the lungs to absorb oxygen, compromising the delivery of oxygen-rich blood to the tissues of the body.Because the heart is working harder against the high pressure, heart failure can develop.Pulmonary hypertension can be idiopathic (the cause is unknown) or inherited (runs in families and is often linked to a specific gene) or may be associated with other medical issues.The October 3, 2012, issue of JAMA contains an article about pulmonary hypertension.
Chronic hypoalbuminemia and edema associated with intestinal lymphangiectasia
Authors: E. J. Fadell
Journal: JAMA (1965)

THE PRESENCE of edema with associated hypoproteinemia in a person who has no manifest renal or liver disease should alert one to the possibility that loss of protein into the intestines may be causative. Increased protein loss into the gut has been demonstrated in a variety of inflammatory and neoplastic diseases of the gastrointestinal tract. Diseases associated with this have been designated protein-losing gastroenteropathies or hypercatabolic protein-losing enteropathies. This category includes celiac disease, sprue, acute gastroenteritis, regional enteritis, ulcerative colitis, intestinal lipodystrophy (Whipple's Disease), Menetrier's disease, and intestinal lymphangiectasia. The use of radioisotopes has clarified the site of loss of serum albumin, and the introduction of the biopsy tube for the small intestine has made tissue available for study of the underlying pathological abnormality. <h3>Report of a Case</h3> The patient, a 52-year-old white woman was first admitted to Methodist Evangelical Hospital on Dec 8, 1962. Her illness dates back approximately
Kidney Atrophy
Authors: Samuel J. Arnold
Journal: JAMA (1964)

<h3>To the Editor:</h3> Reading X-Ray Seminar No. 30 (<i>JAMA</i><b>186</b>:1085 [Dec 21] 1963) has impelled me to comment on some important aspects of this case which, I believe, the participants overlooked entirely or discussed incompletely. I refer to (1) using residual as an indicator of obstruction; (2) failing to consider the urethra as a possible source of stenosis; (3) attributing the hydroureters to pyelonephritis, but ignoring the genesis of the hydrobladder; and (4) neglecting the possible role of back pressure in the production of a hypoplastic kidney. The concept that the absence of residual implies the absence of obstruction should be abandoned, for residual generally reflects decompensation secondary to long-standing resistance, or, possibly, the return of the reflux. The urethra is not merely a nondescript tunnel leading to the bladder, but a very common source of obstructive pathology in symptomatic children. And would it not be more logical to