tbuckley/cabot-search huggingface dataset:
Effectiveness of Clozapine Versus Olanzapine, Quetiapine, and Risperidone in Patients With Chronic Schizophrenia Who Did Not Respond to Prior Atypical Antipsychotic Treatment
Authors: Joseph P McEvoy, Jeffrey A Lieberman, T Scott Stroup, Sonia M Davis, Herbert Y Meltzer, Robert A Rosenheck, Marvin S Swartz, Diana O Perkins, Richard S E Keefe, Clarence E Davis, Joanne Severe, John K Hsiao
Journal: American Journal of Psychiatry (2006)

Objective: When a schizophrenia patient has an inadequate response to treatment with an antipsychotic drug, it is unclear what other antipsychotic to switch to and when to use clozapine. In this study, the authors compared switching to clozapine with switching to another atypical antipsychotic in patients who had discontinued treatment with a newer atypical antipsychotic in the context of the Clinical Antipsychotic Trials for Interventions Effectiveness (CATIE) investigation. Method: Ninety-nine patients who discontinued treatment with olanzapine, quetiapine, risperidone, or ziprasidone in phase 1 or 1B of the trials, primarily because of inadequate efficacy, were randomly assigned to open-label treatment with clozapine (N=49) or blinded treatment with another newer atypical antipsychotic not previously received in the trial (olanzapine [N=19], quetiapine [N=15], or risperidone [N=16]). Results: Time until treatment discontinuation for any reason was significantly longer for clozapine (median=10.5 months) than for quetiapine (median=3.3), or risperidone (median=2.8), but not for olanzapine (median=2.7). Time to discontinuation because of inadequate therapeutic effect was significantly longer for clozapine than for olanzapine, quetiapine, or risperidone. At 3-month assessments, Positive and Negative Syndrome Scale total scores had decreased more in patients treated with clozapine than in patients treated with quetiapine or risperidone but not olanzapine. One patient treated with clozapine developed agranulocytosis, and another developed eosinophilia; both required treatment discontinuation. Conclusions: For these patients with schizophrenia who prospectively failed to improve with an atypical antipsychotic, clozapine was more effective than switching to another newer atypical antipsychotic. Safety monitoring is necessary to detect and manage clozapine’s serious side effects.
Misdiagnosis of tuberculosis
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The sickle cell trait and surgical complications. A matched-pair patient analysis
Authors: S. A. Atlas
Journal: JAMA (1974)

Fifty-six black patients with sickle cell trait, who underwent surgical or diagnostic procedures, were matched for medical procedure, type of anesthesia, age, and sex with black subjects with normal hemoglobin. The frequency and types of complications, and length of stay for the two groups were compared. No significant differences between the two groups were observed on the basis of any of these criteria. (<i>JAMA</i>229:1078-1080, 1974)
Registration of Foreign Physicians
Authors: A. J. Hoenes
Journal: JAMA (1910)

<h3>To the Editor:</h3> There was a time when foreign medical schools, especially those of Germany and England, were considered superior to ours. At the same time there were nongraduate practitioners in all of our states, with no registration laws, and many localities were not supplied with competent physicians. At that time it was expedient to invite foreign graduates to locate here. To-day conditions have changed. Our colleges rank with the best schools in the world; foreigners come to our shores to learn our advanced methods, but our graduates are not recognized in those countries. Our states are now well-supplied with graduate and registered physicians; many of our cities are overcrowded, and yet foreigners, who cannot make a living in their own country, throng in. The profession in Germany is overcrowded. Canadian physicians are pouring into our country and American graduates are crowded out, and have no recourse of protection in
THE BACTERIOLOGY OF THE NOSE IN HEALTH AND DISEASE.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
P1 Which asthmatic patients attend accident and emergency departments?
Authors: A Hill, M Pearson, R Neville, N Richards, J Patience, P Johnson, Ida Johnston, I Hall, D Price, V Mcgovern2, M Mead3, S Moss, C Hind, S Alcock, K Connolly, R Prescott, C Connolly, J Khan, S Fhussain, D Smithl, S Singh, S Revill, Mdl Morgan
Journal: Thorax (1995)

A 3 month prospective study was carried out from May 1994 of all adult asthmatic patients attending our two accident and emergency departments (A&E) in south Glasgow. 106patients attended-71 self referred and 35 General Practitioner (GP) referralsand of these 61 were admitted.There were 58 females and 48 males, age range 16 to 79, mean 36 years.The predominant reasons for attendance were: 79 with an exacerbation and 25 ran out ofan inhaler.In the past year half had used A&E 2 or more times, and almost one third had been admitted.Almost one third ofthe working asthmatics had been off work for 2 or more weeks in the preceding 3 months.From the patient questionnaire (87 filled in): 280/ claimed nobody had ever checked their inhaler technique and 61% had not received any education on worsening asthmatic symptoms.From the hospital follow up at I to 2 weeks (76 attended), we felt 51% had poor symptom control, 45% had poor inhaler technique, and 58% had no self management plans. 98GP questionnaires were returned.They felt (attendees, non attendees to our hospital follow up) that: 89%,54% have moderate or severe asthma; 48%,58% have poor compliance with treatment and/or advice; 39%,71% are poor attendees to the GP clinic.There was no statistical difference when we compared admitted versus non admitted patients in symptom control at follow up, inhaler technique, self management plans, or compliance.Admitted patients were more likely to have moderate or severe asthma (p=0.0006).This study backed by information from general practitioners highlights again the problems of inadequate education and compliance complicating management in these moderate and severe asthmatics.As a group they merit detailed attention and follow up arrangements.
Cessation of Smoking and Reduced Risk of Death-Reply
Journal: JAMA (1985)

<h3>In Reply.—</h3> Dr Seltzer is concerned that Dr Kuller's statements in response to recent advertisements by the R. J. Reynolds Co will "leave the wrong impression" with readers of<i>JAMA</i>. A similar concern about wrong impressions left by Dr Seltzer prompts us to write this letter. Dr Kuller did not say that the "MRFIT experiment establishes that quitting smoking results in a substantial decline in coronary death rate." He said that the "men who quit smoking had a coronary death rate almost 50% below that of those who kept on smoking." Dr Seltzer correctly points out that the MRFIT Research Group<sup>1</sup>carefully discussed these within-group findings so as to convey to readers the fact that theseanalyses did not make use of the randomized design, and therefore the inferences from the data are limited. Dr Seltzer also states that the results of the MRFIT show "clearly that there was
Burst abdomen—a preventable condition?
Authors: Mrs Kershaw, Royal College, R Al Baghdadi, M Alfagih, A Al-Samarrai, I Al-Taie, A Ameen, L Appiah, J Bachir, J Baidya, Pushpa Balasooriya, A Banks, D P S Bhatia, R Bhattacharya, S Bhattacharyya, R Birudavolu, R Boome, J Brice, S Cairns, G Carden, Y Chan, D Andrew, D Chaudhuri, C Datta, A Davies, G Desai, J Dixon, A El, S Dowidar, El Sakaan, R Fahed, B Faizer, M Fernandez, J Flanagan, L Forrest, Kong-Poon Gan, P Gooder, S Govindan, I-Ul Haque, D Higginson, G Hoffman, H Hubbard, N Jain, M Jamal, M Jawad, K Jha, G Kelly, J Khurana, J Kirsten, T Kurukula- Suriya, T Lau, G Lunn, M Luvuno, R Macdougall, L Madhavareddy, A Marsden, M Marzouk, R Matthews, J May, M Mehrez, Vershi Meisheri, M Morales, J Mulcahy, A Mullins, S Murray, C Ng, G Odigie, T E O'hare, A Parvaiz, H Pawar, K B Queen, S Quraishi, S Rao, D Rashid, A Ray, A Roy, A Richards, J Sebastian, B Shahrad, Shanker Narayan, S Singh, S Soutar, M Srivastava, A Stone, V Talati, P Talbot, C Taylor, A Theodorou, G Trengrove-Jones, I Usmani, Chalattil Vijayalakshmy, D Ward, H Wilshaw, A Woodyer
Journal: BMJ (1977)
Chemical Inducers of Differentiation in a Long-Term Renal Cell Line
Authors: Julia E. Lever
Journal: Environmental Health Perspectives (1989)

The long-term renal epithelial cell line LLC-PK1 expresses at confluence several differentiated characteristics of renal proximal tubule including Na/glucose cotransport and several brush border membrane hydrolases. The differentiation-inducing chemical hexamethylene bisacetamide (HMBA) triggers a dramatic induction of Na+/glucose symport, trehalase and maltase, expressed as an increase in the number of cells in the culture that express the differentiated phenotype. Characteristics of the induction response are reviewed in terms of proposed mechanisms of inducer action. New evidence suggests that in addition to elevation of intracellular Na levels mediated by partial inhibition of the sodium pump, HMBA treatment also alters polyamine levels via effects on ornithine decarboxylase. These responses may be mediated by HMBA effects on protein kinase C activity. The possible role of polyamine fluctuations and DNA demethylation in mediating HMBA effects on differentiated gene expression is currently being investigated.
Abstract 5382: Accelerated Triacylglyceride Dynamics Induced by Cardiac PPARα Overexpression are Potentiated by Adrenergic Stress to Reveal Increased Reliance on Endogenous Lipid Stores
Authors: Natasha H Banke, Teresa C Leone, Daniel P Kelly, E. D Lewandowski
Journal: Circulation (2008)

Peroxisome proliferator-activated receptor alpha (PPARα) is a nuclear receptor involved in regulating fatty acid utilization and is implicated in the pathogenesis of diabetic cardiomyopathy. However, the involvement of PPARα in the specific utilization of endogenous lipid stores and the consequences for triacylglyceride (TAG) formation in the cardiomyocyte remain unknown. Thus, we examined TAG dynamics in isolated perfused hearts of transgenic mice exhibiting cardiac-specific over-expression of PPARα under normal and stressed conditions. Hearts from MHC-PPARα overexpressing mice (PPAR) and non-transgenic (NTG) littermates were isolated and retrogradely perfused in a 14.1 T NMR magnet with buffer containing 0.4 mM [2,4,6,8,10,12,14,16]-13C palmitate, as a source of long chain fatty acids (LCFA) + 10 mM glucose. Dynamic 13C NMR observations of the beating heart and endpoint mass spectrometry provided TAG turnover at baseline work (PPAR, n=12; NTG, n=7) and adrenergic stress (10–7 M isoproterenol, ISO) (PPAR ISO, n=5; NTG ISO, n=6). ISO elevated rate pressure product by 27% and 25% in NTG and PPAR, respectively (P&lt;0.05). At baseline workloads, PPAR contained 45% more TAG than NTG (P &lt;0.05) and TAG turnover was elevated in PPARα mice by 191% over NTG. ISO did not affect TAG content in either NTG or PPAR. However, ISO induced large increases in TAG turnover in PPAR from 1454 ± 232 to 2532 ±334 nanomoles/mg prot/min (P&lt;0.05), without affecting TAG turnover in NTG. The near doubling of TAG turnover with elevated content in MHC-PPARα hearts indicates upregulated baseline lipid metabolism via both utilization and storage pathways. Surprisingly, the adrenergic stress response potentiates the already elevated TAG dynamics in MHC-PPARα hearts, indicating persistence in matching LCFA storage rates to maintain this elevated endogenous lipid pool. Elevated TAG content in PPAR was maintained during ISO, despite increased reliance on endogenous TAG to meet the increased energy demand as compared to NTG. Therefore, activation of LCFA oxidation enzymes by PPARα is coupled in complementary fashion to the activation of LCFA storage kinetics, suggesting an expanded role for PPARα in the induction of TAG turnover.
Coronary artery bypass surgery. NCHCT Technology Assessment Forum
Journal: JAMA (1981)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE MEDICINAL TREATMENT OF PULMONARY TUBERCULOSIS.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Milroy Lectures ON THE HYGIENIC ASPECT OF THE COAL-MINING INDUSTRY IN THE UNITED KINGDOM: Delivered before the Royal College of Physicians of London
Authors: F. Shufflebotham
Journal: BMJ (1914)

4= I9=IMC1A .Ut 5 5. Doubt rewnains as to tlhe,exact, route of infection: if infection was established in the accepted way-by means of aii infective stalk passing through the tympanic roof, tlhrough the dura, and tlleni along the course of tlle vessels of the pia mater to their free bifurcation beyond the deep surface of the grey miatter-the facts at least show how small may be the clhanges in these intermediate tissues for the establislhment of a large abscess in the temporo- spllenoidal lobe.I ani indebted to Dr.
Decompression Sickness, an Emerging Recreational Hazard
Authors: A. Warner Dewey
Journal: New England Journal of Medicine (1962)

ATHLETIC injuries have recently become the focus of active attention in medical literature. Types of trauma peculiar to football, boxing, the trampoline and water skiing, to name only a few, have been cited, together with appropriate recommendations for treatment and prevention. Even that anomaly (euphemistically called a dance) known as the "twist" has been indicted for being a source of certain types of knee injury. However, to date, a comparable awareness and understanding of certain injuries peculiar to scuba diving‡ remain lacking; of these, the least widely appreciated is decompression sickness (otherwise variously known as the "bends," the "chokes," the . . .
LICENSURE: FACTS AND FIGURES
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Physiologic Significance of a Record Aeroplane Flight
Journal: JAMA (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Musk ambrette
Authors: M.A. Cooke, F. Grundschober
Journal: British Journal of Dermatology (1987)

Journal Article Musk ambrette Get access M.A. Cooke, M.A. Cooke Technical Advisory Committee, International Fragrance Association, 20 Kelmscott Road, Harborne, Birmingham B17 8QN, U.K. Telephone: (0)21‐427‐2370, (0)21‐426‐2354 Search for other works by this author on: Oxford Academic Google Scholar F. Grundschober F. Grundschober International Fragrance Association, 8 Rue Charles‐Humbert, CH‐I205, Geneva, Switzerland. Telephone: (0)22‐213‐548 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 116, Issue 2, 1 February 1987, Page 278, https://doi.org/10.1111/j.1365-2133.1987.tb05831.x Published: 01 February 1987
Physiological and chemical characterization of cyanobacterial metallothioneins.
Authors: R W Olafson
Journal: Environmental Health Perspectives (1986)

Techniques have been developed for detection, quantitation, and isolation of bacterial metallothioneins (MTs) from cyanobacterial species. These methods involve differential pulse polarography and reverse-phase high-performance liquid chromatography (HPLC) and have allowed detection of picomole quantities of these high sulfhydryl content proteins. The prokaryotic molecule was found to be induced in the presence of Cd or Zn salts with regulation at the level of transcription. Cu was not found to induce synthesis of the prokaryotic MT. Exposure to the former metals resulted in a growth lag followed by simultaneous induction of MT synthesis and onset of growth. Amino acid analysis and N-terminal sequence analysis indicated that the bacterial MTs from cyanobacteria are unique, having many aromatic and aliphatic residues and no apparent association of hydroxylated or basic amino acids with cysteines. Although the characteristic Cys-X-Cys sequences were present, no apparent amino acid sequence homology with the eukaryotic MTs was found in the first 42 residues.