tbuckley/cabot-search huggingface dataset:
LECITHIN AND ITS THERAPEUTIC USE.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Issue Information ‐ TOC
Authors: Vajinder Kumar, Sanjay Patel, Rahul Jain, Fubo Zhou, Wenting Shang, Xiaoling Yu, Jie Tian, Joe Tomaszewski, Binghe Wang, Minyong Li, Mengyuan Zhu, Amjad Ali, Wilfred Armarego, Matthew Bogyo, Vincenzo Calderone, Haian Fu, Gunda Georg, Amanda Hargrove, Kenneth Jacobson, Patrick Lam, Philip Low, Christian Melander, Joseph Ready, Webster Santos, Teruna Siahaan, Claudiu Supuran, Dhiren Thakker, Alexander Tropsha, Lihe Zhang, George Destevens, Bingchen Yu
Journal: Medicinal Research Reviews (2018)

The journal publishes timely critical reviews of topics related to medicinal research, broadly defined, to which the authors have made significant contributions.Appropriate topics include, but are not limited to, the underlying pathophysiology of important diseases and disease vectors; therapeutic approaches to the treatment of various diseases; the properties of molecular targets for therapeutic agents; important new methodologies facilitating the search for therapies; genomics and proteomics; structure-activity correlations of drug series; the development of new imaging and diagnostic tools; drug metabolism; drug delivery; and chemical, pharmacological, pharmacokinetic, pharmacodynamic, and clinical characteristics of important drugs.Reviews are mainly solicited by the editors; however, voluntary contributions are also encouraged.In the latter case, potential authors are asked to contact the Editor-in-Chief with an outline before beginning to write in order to avoid duplication of effort and to ensure suitability of the topic and the level of coverage.
Clinical outcomes with multikinase inhibitors after progression on first-line atezolizumab plus bevacizumab in patients with advanced hepatocellular carcinoma: A multinational, multicenter retrospective study.
Authors: Changhoon Yoo, Jwa Hoon Kim, Min-Hee Ryu, Sook Ryun Park, Joycelyn Jie Xin Lee, Wai Meng David Tai, Stephen Lam Chan, Baek-Yeol Ryoo
Journal: Journal of Clinical Oncology (2021)

272 Background: Atezolizumab-bevacizumab is the new standard of care for first-line treatment of advanced hepatocellular carcinoma (HCC). However, the optimal sequence of therapy after disease progression on atezolizumab-bevacizumab is unclear. Methods: This multinational, multicenter, retrospective study assessed clinical outcomes of patients with advanced HCC who received subsequent systemic therapy after progression on atezolizumab-bevacizumab in Korea, Hong Kong and Singapore between July 2016 and April 2019. Results: A total of 49 patients were included; the median age was 60 years (range, 3780) and 73.5% were male. All patients were classified as Child-Pugh A and Barcelona-Clinic Liver Cancer stage C. Multikinase inhibitors (MKIs), including sorafenib (n = 29), lenvatinib (n = 19), and cabozantinib (n = 1), were used as second-line therapy for all patients. The objective response rate (ORR) and disease control rate (DCR) were 6.1% and 63.3%, respectively, in all patients. With a median follow-up duration of 11.0 months, median progression-free survival (PFS) and overall survival (OS) were 3.4 months (95% confidence interval [CI] 1.84.9) and 14.7 months (95% CI 8.121.2) in all patients. Median PFS with lenvatinib was significantly longer than that with sorafenib (6.1 months vs. 2.5 months; P= 0.004), although there was no significant difference in median OS (16.6 months vs. 11.2 months; P= 0.347). Treatment-related adverse events (TRAEs) of any grade and grade 3 occurred in 42 (85.7%) and 8 (16.3%) of patients. Common TRAEs included hand-foot syndrome (HFS) (n = 26, 53.1%), fatigue (n = 14, 28.6%), hypertension (n = 14, 28.6%), and diarrhea (n = 12, 24.5%). Conclusions: Second-line treatment with MKIs, mostly sorafenib and lenvatinib, showed comparable efficacy and manageable toxicities in patients with advanced HCC after disease progression on atezolizumab-bevacizumab.
Principles and Practice of Endocrinology and Metabolism
Authors: Frederick G. Berlinger
Journal: JAMA (1996)

<i>Principles and Practice of Endocrinology and Metabolism</i>, second edition, by Kenneth L. Becker is a thoroughly comprehensive review of the science of endocrinology with major emphasis on the clinical aspects. The orientation is heavily toward specific disease states, stressing the basic chemistry, pathophysiology, diagnosis, and treatment. The text will be of major use to both the primary care physician and the clinical endocrinologist, as the subject ranges from the more common syndromes, such as thyroid dysfunction, diabetes mellitus, and parathyroid, pituitary, adrenal, and gonadal disorders, to the more esoteric, such as bombesinlike peptides, kinins, and neurotensin. Subspecialists other than endocrinologists would profit from reviewing such sections as "Diffuse Hormone Secretion," which covers endocrine aspects of pulmonary, cardiac, gastrointestinal, renal, and other organ systems. Highlighted in gray are portions of everyday use to any clinician, which summarize endocrine medications, effects of various drugs on endocrine function and laboratory tests, "Reference Values
Article on Combining Recombinant Cancer Vaccine with Radiotherapy
Journal: Clinical Cancer Research (2006)

In the article Combining a Recombinant Cancer Vaccine with Standard Definitive Radiotherapy in Patients with Localized Prostate Cancer, the first footnote of Table 2 is incorrect and should read, as follows: Number of cycles with toxicity (percentage of cycles with toxicity). Also, the data included in Table 2 were for the first 109 vaccine cycles (from a total of 139 given). The data regarding the percentage of cycles with toxicity do not change substantially when examining all 139 cycles.Gulley JL, Arlen PM, Bastian A, et al. Combining a recombinant cancer vaccine with standard definitive radiotherapy in patients with localized prostate cancer. Clin Cancer Res 2005;11:3353–62.
Association Between Invasive Lobular Breast Cancer and Mutations in the Mismatch Repair Gene <i>MSH6</i>—Reply
Authors: Hsiao-Mei Lu, Shuwei Li, Mary Helen Black
Journal: JAMA Oncology (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
The Cover
Authors: Beverly Merz
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
In This Issue
Journal: Circulation Research (2011)

Peptide Interference of CaM-Cyclin E Interactions (p 1053)Hui et al have designed a small peptide that could help prevent restenosis after angioplasty.Following angioplasty to fix a narrowing artery, it is often the case that renarrowing, or restenosis, occurs.A major cause of restenosis is the proliferation of vascular smooth muscle cells (VSMCs).Preventing such proliferation has, thus, been considered a promising avenue of therapeutic investigation.Because their research suggested that VSMC proliferation depends on the binding of calmodulin to cyclin E, Hui et al designed a peptide that would inhibit this interaction.When this 22amino acid peptide, based on the calmodulin binding sequence of cyclin E, was transfected into VSMCs, it inhibited cell cycle progression.The team initially electroporated the peptide into cells, but once they had established its success, they switched to a therapeutically feasible delivery system-fusing their peptide to the TAT protein of human immunodeficiency virus, which enters cells with high efficiency.The TAT fusion peptide not only stopped proliferation of mouse and human cells in culture, it also limited neointima formation (vessel wall thickening) in a mouse model of arterial injury.The authors suggest that such a fusion peptide could be introduced at the time of angioplasty in the form of a drugeluting stent and, thus, prevent local VSMC proliferation for a prolonged period of time.
THE SPIROCHETICIDAL VALUE OF DISODIUM ETHYL ARSINATE (MON-ARSONE)
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SUICIDE STATISTICS
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Evaluation of structure and function of spleen with radioactive tracers
Authors: H. N. Wagner
Journal: JAMA (1967)

Thevolvement of the spleen is well recognized in some diseases, such as lymphomas, and very likely in others, such as hemolytic anemias. Structural abnormalities, such as enlargement or functional disturbances, such as accelerated removal of red blood cells (RBCs), are often present. The combination of radioactive tracers and external radiation detectors permits measurement of the rate of uptake and spatial distribution of labeled RBCs in the spleen. We can already visualize splenic structure by scanning, and it may soon be possible to evaluate splenic function in a manner similar to the measurement of the rate of uptake of radioactive iodine by the thyroid. The method of labeling RBCs with radioactive chromium (<sup>51</sup>Cr) was discovered in 1950 by Gray and Sterling.<sup>1</sup>This technique made possible extensive study of the fate of normal and abnormal erythrocytes. The technique consists of mixing a few milliliters of venous blood with sodium chromate
KOCH'S EXPERIMENTS WITH THE RINDERPEST.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Coronary reperfusion: medical, surgical, or not at all?
Authors: K. L. Gould
Journal: JAMA (1982)

In this issue of The Journal (p 1325), Phillips et al report improved ventricular function and survival in patients undergoing immediate bypass surgery for acute myocardial infarction, findings similar to their earlier observations in 1979.<sup>1</sup>Berg<sup>2</sup>and DeWood et al<sup>3</sup>from Spokane, Wash, initially reported improved survival in patients who had undergone coronary bypass surgery as compared with medically treated patients with acute myocardial infarction. These articles demonstrate both the promise and the problems of innovative, aggressive intervention to reperfuse jeopardized myocardium, demonstrated by most,<sup>4-7</sup>but not all,<sup>8-10</sup>experimental studies to be beneficial. On the positive side, Phillips et al have set aside arbitrary assumptions about a fixed, maximum duration of chest pain beyond which salvage is considered infeasible. Their decision for surgical intervention depended on clinical evidence of ongoing ischemia that indicated remaining viable myocardium as compared with depending on rigid time periods based
Serum creatine phosphokinase and myocardial infarction
Authors: B. E. Sobel
Journal: JAMA (1974)

ELEVATED level of serum creatine phosphokinase (CPK) activity is a well recognized manifestation of acute myocardial infarction. Recently, total CPK and CPK isoenzyme determinations have been utilized to improve<i>detection, quantification</i>, and<i>projection</i>of the evolution of infarction as well. <h3>Improved Detection</h3> Three CPK isoenzymes (MM, BB, MB) may appear in serum—each a dimer composed of two subunits of the M or B type. Myocardium contains the MB form as well as MM in contrast to skeletal muscle. Myocardial injury is associated with elevation of MB CPK levels. In contrast, after injury to skeletal muscle, serum CPK increases reflect MM activity. By detecting electrophoretically separated serum CPK isoenzymes with a fluorescence assay affording increased sensitivity, Roe and his colleagues have substantially facilitated the detection of myocardial infarction. Although they have cautioned that elevated levels of MB activity are not uniquely associated with myocardial injury, they have demonstrated that isoenzyme MB
THYROID FUNCTIONS AND THERAPY
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 593: Hemodynamic Effect of a δ Opioid Receptor Agonist DADLE on Rats with Hemorrhagic Shock
Authors: Tong Wang, Xiaohong Lin, Haidong Wu, Yue Fu, Zitong Huang
Journal: Circulation (2008)

Delta opioid receptor agonist can reduce the metabolism and energy demand of ischemic organs in ischemic/reperfusion injury. H-Tyr-D-Ala-Gly-Phe-D-Leu-OH (DADLE) is a delta opioid receptor agonist. In the present study, we investigated the hemodynamic effect of DADLE on rats with hemorrhagic shock. DADLE can improve the hemodynamics of rats with hemorrhagic shock. Thirty six healthy male SD rats were randomly divided into sham group, control group and DADLE group(1mg/kg group and 5mg/kg group). The control and DADLE animals were bled in 10 minutes by uninterrupted withdrawal from the arterial catheters to set up the model of hemorrhagic shock, then maintained MAP at about 40 mmHg for 60 minutes. All animals were observed for 3 hours after resuscitation with saline injection or DADLE injection and SAP, DAP, MAP, LVSP and ±dP/dtmax were recorded at 30, 60, 90, 120, 180 minutes following injection. After resuscitation, MAP, LVSP and ±dP/dtmax were unchanged in the control group, and remained downtrend. In contrast, significant increases(p&lt;0.01) were found in all hemodynamic data following the administration of DADLE (1mg/kg or 5mg/kg), and the peak values were reached at 30 minutes. There was no significant difference between 1mg/kg and 5mg/kg DADLE groups. DADLE improves the hemodynamics during the course of hemorrhagic shock.
PORTAL THROMBOSIS WITH HEMORRHAGIC INFARCTION AND NECROSIS OF THE LIVER.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal