tbuckley/cabot-search huggingface dataset:
Primary hospital for a Presidential visit. Recommendations for designated community hospitals
Authors: H. E. Carr
Journal: JAMA (1977)

HOW DOES an 82-bed community hospital respond to the official White House designation of "primary hospital" for emergency services during a presidential visit? The Clinton Hospital was faced with this dilemma when President Carter decided to visit Clinton, an industrialized but relatively isolated town of 13,900 population located in north central Massachusetts. His visit was part of a campaign promise to keep in touch with the people. His advisors chose Clinton as a typical American town. The President accepted invitations to participate in its town meeting held March 16, 1977, and to remain overnight in the home of a private citizen. During his participation at the town meeting, President Carter was greeted by 15,000 people outside and 850 people inside the town hall. This was reported recently in a supplement entitled<i>The Visit</i>in the<i>Clinton Daily Item Press</i>, April 21, 1977. In the absence of formal guidelines, our hospital's
Mutation Frequencies in Patients With Early-Onset Colorectal Cancer
Authors: Steven A. Narod, Mohammad Akbari
Journal: JAMA Oncology (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
DISREPUTABLE ADVERTISERS AND THE MAILS.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Incorrect Data in: Benefits and Risks of Tight Glucose Control in Critically Ill Adults: A Meta-analysis
Authors: Ze-Zhou Song
Journal: JAMA (2009)

likely to benefit from intervention such as surgery would be highly desirable.Valvular calcification was not described in the study by Tzemos et al, although the extent of such calcification has been found to be a strong independent predictor of outcome of aortic stenosis, 2 congruent with how the disease process at the tissue level is understood.In addition, valvular calcification increases leaflet stiffness and reduces systolic opening, eventually leading to a reduction in the area of the valve, so calcification could be present before aortic stenosis.If valvular calcification was independently associated with primary cardiac events, it may be a better predictor of outcome that could help in the selection of patients who are likely to benefit from intervention.
Role of Metabolic Activation in the Pathogenesis of Chemically Induced Pulmonary Disease: Mechanism of Action of the Lung-Toxic Furan, 4-Ipomeanol
Authors: Michael R. Boyd
Journal: Environmental Health Perspectives (1976)

Many xenobiotics produce hepatic injury due to their metabolism in the liver to highly reactive electrophile intermediates which form covalent conjugates with nucleophilic cellular constituents. This presentation describes studies indicating that the production of chemically reactive metabolites by pulmonary metabolism of xenobiotics can also play a fundamental role in the pathogenesis of chemically induced lung disease.
PPAR γ insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors
Authors: Toru Akune, Shinsuke Ohba, Satoru Kamekura, Masayuki Yamaguchi, Ung-il Chung, Naoto Kubota, Yasuo Terauchi, Yoshifumi Harada, Yoshiaki Azuma, Kozo Nakamura, Takashi Kadowaki, Hiroshi Kawaguchi
Journal: Journal of Clinical Investigation (2004)

Based on the fact that aging is associated with a reciprocal decrease of osteogenesis and an increase of adipogenesis in bone marrow and that osteoblasts and adipocytes share a common progenitor, this study investigated the role of PPARγ γ, a key regulator of adipocyte differentiation, in bone metabolism.Homozygous PPARγ γ-deficient ES cells failed to differentiate into adipocytes, but spontaneously differentiated into osteoblasts, and these were restored by reintroduction of the PPARγ γ gene.Heterozygous PPARγ γ-deficient mice exhibited high bone mass with increased osteoblastogenesis, but normal osteoblast and osteoclast functions, and this effect was not mediated by insulin or leptin.The osteogenic effect of PPARγ γ haploinsufficiency became prominent with aging but was not changed upon ovariectomy.The PPARγ γ haploinsufficiency was confirmed to enhance osteoblastogenesis in the bone marrow cell culture but did not affect the cultures of differentiated osteoblasts or osteoclast-lineage cells.This study demonstrates a PPARγ γdependent regulation of bone metabolism in vivo, in that PPARγ γ insufficiency increases bone mass by stimulating osteoblastogenesis from bone marrow progenitors.Nonstandard abbreviations used: alkaline phosphatase (ALP); bone morphogenetic protein-2 (BMP-2); bone volume (BV); CCAAT enhancer-binding proteins (C/EBPs); computed tomography (CT); LDL receptor-related protein 5 (LRP5); leukemia inhibitory factor (LIF); M-CSF-dependent bone marrow macrophage (M-BMMφ); receptor activator of nuclear factor κB ligand (RANKL); ovariectomy (OVX); PPAR responsive element (PPRE); tartrate-resistant acid phosphatase (TRAP); tissue volume (TV); type I collagen α1 chain (COL1A1).
The cardiovascular effects of mechanical ventilation and positive end-expiratory pressure
Authors: J. M. Luce
Journal: JAMA (1984)

IN PATIENTS with diffuse lung disease due to the adult respiratory distress syndrome (ARDS), mechanical ventilation (MV), and positive endexpiratory pressure (PEEP) commonly are used to improve the Pao<sub>2</sub>. This is done despite the fact that MV and PEEP may depress cardiac output and thereby reduce systemic oxygen transport.<sup>1</sup>In this article, the complex and often controversial cardiovascular effects of MV and PEEP are reviewed by focusing on the determinants of cardiac output. Guidelines to minimize the cardiovascular effects of MV and PEEP in patients with ARDS are also provided. <h3>Determinants of Cardiac Output</h3> Cardiac output is the product of the ventricular stroke volume and heart rate. Heart rate is influenced by sympathetic and parasympathetic nervous system activity that is mediated in part by the baroreceptor reflex involving receptors in the carotid sinus and aortic arch. Stroke volume is determined by three factors: (1) preload, the length of cardiac muscle
OP0345 DOES IMMUNOLOGICAL REMISSION, DEFINED AS DISAPPEARANCE OF AUTOANTIBODIES, OCCUR WITH CURRENT TREATMENT STRATEGIES? A LONG-TERM FOLLOW-UP STUDY IN RHEUMATOID ARTHRITIS PATIENTS WHO ACHIEVED A SUSTAINED DMARD-FREE STATUS
Authors: Debbie Boeters, Leonie Burgers, Rene Toes, Annette van der Helm - van Mil
Journal: Annals of the Rheumatic Diseases (2019)

<h3>Background</h3> Sustained disease modifying antirheumatic drug (DMARD)-free status, the sustained absence of synovitis after cessation of DMARD-therapy, is infrequent in autoantibody-positive RA, but approximates cure (i.e. disappearance of signs and symptoms). It was recently suggested that immunological remission, defined as disappearance of anticitrullinated protein antibodies (ACPA) and rheumatoid factor (RF), underlies this outcome.<sup>1</sup> However, the association between seroreversion and cure of disease has not been extensively studied before. <h3>Objectives</h3> To determine in a long-term observational study if autoantibodies disappear in RA-patients who achieved sustained DMARD-free remission. <h3>Methods</h3> We studied 95 ACPA- and/or RF-positive RA-patients who achieved DMARD-free remission after median 4.8 years and kept this status for the remaining follow-up (median 4.2 years). Additionally, 21 autoantibody-positive RA-patients with a late flare, defined as recurrence of clinical synovitis after a DMARD-free status of ≥1 year, and 45 autoantibody-positive RA-patients who were unable to stop DMARD-therapy (during median 10 years) were studied. Anti-CCP2 IgG, IgM and RF IgM levels were measured in 587 samples obtained at diagnosis, before and after achieving DMARD-free remission. <h3>Results</h3> 12.8% of anti-CCP2 IgG positive RA-patients had seroreverted when achieving remission. In RA-patients with a late flare and with persistent disease this was 8.3% and 5.7%, respectively (p=0.63, Figure). For anti-CCP2 IgM and RF IgM similar results were observed. Evaluating the estimated slope of serially measured levels revealed that RF-levels decreased more in patients with than without remission (p&lt;0.001); the course of anti-CCP2 levels was not different (p=0.66). <h3>Conclusion</h3> Sustained DMARD-free status in autoantibody-positive RA was not paralleled by an increased frequency of reversion to autoantibody-negativity. This form of immunological remission should therefore not be a treatment target. <h3>Reference</h3> [1] Schett G, Emery P, Tanaka Y, et al. Tapering biologic and conventional DMARD therapy in rheumatoid arthritis: current evidence and future directions. Ann Rheum Dis 2016;75:1428–37. doi:10.1136/annrheumdis-2016-209201 <h3>Disclosure of Interests</h3> Debbie Boeters: None declared, Leonie Burgers: None declared, Rene Toes Grant/research support from: Sanofi, Annette van der Helm - van Mil Grant/research support from: The research leading to these results has received funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (Starting grant, agreement No 714312) and from the Dutch Arthritis Foundation. The funding source had no role in the design and conduct of the study.
Medical Malpractice
Authors: James P. LoGerfo
Journal: JAMA (1979)

<h3>To the Editor.—</h3> This letter is to note major defects in the article by Doherty and Haven, "Medical Malpractice and Negligence: Sociodemographic Characteristics of Claimants and Nonclaimants" (238:1656, 1977). Simply stated, the authors' control group is entirely inadequate in view of preexisting knowledge about determinants of malpractice and the sociodemographic correlates of use of surgical procedures. Additionally, the statistical analysis of the data is inadequate. The defects are such that no conclusions should be drawn from the study. If one desires to assess the independent effects of sociodemographic characteristics on the risk of litigation, then it is critical to adjust for medical characteristics known to relate to the probability of a suit. Accordingly, the appropriate control group should not consist of a random sample of all hospital admissions, but rather, a sample matched, at the very least, for such broad characteristics as admitting service (orthopedics, pediatrics, medicine, and general surgery)
The in vivo effect of hepatotrophic factors augmenter of liver regeneration, hepatocyte growth factor, and insulin-like growth factor-II on liver natural killer cell functions
Authors: A Francavilla
Journal: Hepatology (1997)

Fine balanced sequential changes of the levels of circulating hepatotrophic factors are essential for normal liver regeneration. Our recent studies have indicated that liver-resident natural killer (NK) cells are important regulators of liver regeneration and have raised the possibility that hepatotrophic factors might mediate their activities through NK cells. In the present study, we assessed the effects of in vivo administration of three hepatotrophic factors (augmenter of liver regeneration [ALR], insulin-like growth factor-II [IGF-II], and hepatocyte growth factor [HGF]) on NK cells in normal rats. Each of the three, given over a 1-day period in doses known to produce hepatotrophic activity, induced inhibition of NK cell cytotoxic activities in the population of mononuclear leukocytes (MNL) in the liver, but not in MNL from the spleen or peripheral blood. In contrast to these results obtained by the whole animal treatment, the three molecules had no effect on NK cell functions when added to cultures of MNL from the livers, spleens, or blood of untreated rats. These data support and extend our previously advanced hypothesis that ALR and other hepatotrophic factors play an important role in liver regeneration by regional regulation of NK cells through some as-yet-unknown intermediary mechanism. (Hepatology 1997 Feb;25(2):411-5)
Massachusetts Medical Society
Authors: John J. Hunter
Journal: New England Journal of Medicine (1963)

APPLICANTS FOR FELLOWSHIPPublished in Accordance with the Provisions of Chapter V, Section 2, of the By-LawsBerkshireAppleyard, Frederick Lawrence, North Adams Hospital, North Adams. University of Alberta Faculty of Medicine, 1955.Perera, Richard Decio, 369 South Street, Pittsfield. New York Medical College, 1958.Rasch, Hans, Taylor Street, Hinsdale. University of Munich, 1942. Sponsor: Dr. Gerald L. Haidak, 377 Pomeroy Avenue, Pittsfield.Michael L. Cancilla, M.D., Secretary 741 North Street, PittsfieldBristol NorthBoragine, Robert J., 211 Park Street, Attleboro. Tufts University School of Medicine, 1956.Alan Chastanet, M.D., Secretary 375 Oak Street, FranklinBristol SouthKirkaldy, James K. . . .
Splenectomy in Treatment of Secondary Hypersplenism
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Selections from the Papers and Speeches of John Chalmers DaCosta, M.D., LL.D., Samuel D. Gross Professor of Surgery at the Jefferson Medical College, Philadelphia.
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
OSTEOPLASTIC OPERATIONS.
Authors: D. KÜSTER
Journal: JAMA (1907)

Let me thank you for your cordial and honorable invitation, which gives me the occasion to speak on a theme with which I have been occupied often and for a long time—osteoplastic operations. We may divide the methods of operation which aim at remedying a defect of bone into three groups: First, the supplying flap is completely loosened from its natural connection and implanted into a new place; this method may be called grafting or incision. Second, the supplying flap remains in connection with the maternal ground by means of a nourishing bridge of tissues; it may exclusively be called transplantation. The methods of the third group are known under the name of temporary resection or replantation; the piece of bone is dislocated from the maternal ground only until the operation is finished. All these groups contain important and noteworthy methods of operation. <h3>FIRST GROUP. INCISIONS.</h3> In 1825 Philipp von
Decreased cyclin B1 expression contributes to G&lt;SUB&gt;2&lt;/SUB&gt; delay in human brain tumor cells after treatment with camptothecin
Authors: Anna J. Janss, Amit Maity, Cheng-Bi Tang, Ruth J. Muschel, W. Gillies McKenna, Leslie Sutton, Peter C. Phillips
Journal: Neuro-Oncology (2001)

DNA damage produces delayed mitosis (G 2 /M delay) in proliferating cells, and shortening the delay sensitizes human malignant glioma and medulloblastoma cells to cytotoxic chemotherapy.Although activation of the cyclin-dependent kinase CDC2 mediates G 2 /M transition in all tumor cells studied to date, regulation of CDC2 varies between tumor types.Persistent hyperphosphorylation of kinase and reduced cyclin expression have been implicated as mediators of treatmentinduced G 2 delay in different tumor models.To evaluate regulation of G 2 /M transition in human brain tumors, we studied the expression and/or activity of CDC2 kinase and cyclins A and B1 in U-251 MG and DAOY medulloblastoma cells after their treatment with camptothecin (CPT).Synchronized cells were treated during S phase, then harvested at predetermined intervals for evaluation of cell cycle kinetics, kinase activity mRNA, and protein expression.CPT produced G 2 delay associated with decreased CDC2 kinase activity and cyclin B1 expression.Kinase activity was associated with CDC2 bound to cyclin B1, not cyclin A, in both cell lines.Cyclin A mRNA and protein expression were reduced after CPT treatment; however, decreased protein expression was short lived and moderate in the glioma and primitive neuroectodermal tumor/medulloblastoma cells, respectively.We conclude that G 2 delay is a common response of brain tumor cells to chemotherapy with topoisomerase I inhibitors and that a mechanism of this delay may be reduced expression of cyclin B1.
BILLINGS THE GREAT BIBLIOTHEC
Journal: JAMA (1961)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Growth in the international physician supply. 1950 through 1979
Authors: D. A. Kindig
Journal: JAMA (1985)

The recent growth in domestic physician supply prompted an investigation of international trends. Using data from the World Health Organization, it was determined that the number of physicians in the world grew from 4.8 per 10,000 population to 10.1 per 10,000 during the period 1950 through 1979. There was a 96% increase in industrialized nations, 223% in nations with centrally planned economies, 164% in middle-income nations, and 29% in low-income nations. Relationships in growth in physician supply and production of medical graduates are discussed. Implications of the inequities between the various groupings of countries are discussed. (<i>JAMA</i>1985;253:3129-3132)
Very low-calorie diets for obesity
Authors: G. D. Kaplan
Journal: JAMA (1994)

<h3>In Reply.</h3> —Dr Holt speaks for the many compassionate mainstream physicians who skillfully use palliative care and privately struggle with the agonizing dilemmas still faced sometimes by dying patients and their families. Such physicians often express frustration about the reprimands and abstract, overly simplified solutions espoused by ethicists who seem to ignore the clinical realities that they face.<sup>1</sup>We need to create an open environment that encourages physician compassion and creativity and provides physicians with consultation and support rather than simple proscriptions. The voice of these physicians has been largely missing from the debate about physician-assisted suicide. Dr King reminds us that assisted death should never be a substitution for good palliative care. The criteria proposed by Drs Cassel, Meier, and me attempt to ensure that hospice care has been fully utilized, depression has been treated, and patient judgment is clear and unwavering.<sup>2</sup>Assisted death is not an