tbuckley/cabot-search huggingface dataset:
AASLD Program (pp. 27A–77A)
Authors: J Millis, James Trotter, Charles Miller, Saul Karpen, Estella Alonso, Saul Karpen, Ronald Sokol, John Belmont, James Crawford, Peter Harris, Saul Karpen, M Bishr, Omary Ronald, J Sokol, Kenneth Zaret, Todd Baron, Deriiirs \msrn, Briice Bacon, Zachary Goodman, Elizabeth Brunt, E Heathcute, Albert Czaja, Adrian Di Bisceglie, Norali Terrault, Mitchell Skiffman, Emmet Keeffe, William Balistreri, Michael Manns, Andrew Mason, Keith Lindor, Sclerosing Cholangitis, Cholangiocarcinoma Kirsteiz Boberg, Thomas Boyer, Eugene Schifi, Paul Watkins, Kamal Ishak, William Lee, Bruce Bacon, Lawrence Friedman, Bruce Bacon, Jay Lefkowitch, John Craig, Nezam Afdhal, Stephanie Wanless, Lnrcwe Porwll, Anthony Tazdl, D Arid, Peter Fererici, Michml Czap, Laurie Wi, Stephanos Hadziyannis, D Nnd Dour5, B Strader, Chi Istophcr Day, Paul Adams, Paul Angulo, Nathan Bass, Herbert Bonkovsky, Alastair Burt, Jeffrey Crippin, Laurie Deleve, Gregory Everson, Jacquelyn Fleckenstein, Scott Friedman, Joel Greenson, E Heathcote, William Jarnagin, Lennox Jeffers, David Kleiner, Joel Lavine, Steven Meranze, Alexander Monto, James Neuberger, John Olynyk, Eve Roberts, Tania Roskams, Michael Schilsky, Doris Strader, Steven Strasberg, Swan Thung, Vijayan Balan, William Balistreri, D Montgomery Bissell, Kirsten Boberg, David Brenner, Christopher Day, Geoffrey Farrell, Peter Ferenci, Claus Fimmel, Milton Finegold, J Henderson, Michael Heneghan, Stefan Hubscher, Emmet Keefe, Marlyn Mayo, Timothy Morgan, Marion Peters, Antonello Pietrangelo, Laurie Powell, Caroline Riely, Morris Sherman, Mitchell Shiffman, Grace Su, Anthony Tavill, Ian Wanless, Gary Davis Grantlresearch, Roche Sciclone, Douglas Dieterich, Neil Kaplowitz, Axcan Scandipharm
Journal: Hepatology (2003)

Review the criteria and evaluation process for donors and recipients.Understand the basic technical aspects of the surgery.Describe the post-operative outcomes and complications in donors and recipients.Gain insight into the impact of MELD on live donor liver transplantation.Discuss the role of LDLT in hepatitis C, hepatocellular carcinoma and re-transplantation.Adult-to-adult right hepatic lobe LDLT has rapidly emerged as a treatment option for selected patients with end-stage liver disease.Approximately lop) of all liver transplantations performed in the United States utilize a living donor.This course is designed to inform physicians about the current topics in this rapidly changing field.From the medical standpoint, the process of donor and recipient selection will be discussed, including radiologic imaging techniques, financial aspects and the psychosocial assessment of donors.The technical aspects of the surgery will be described along with the postoperative complications in donors and recipients.Three current controversial issues in LDLT will be explored: hepatocellular carcinoma, hepatitis C, regulation of the procedure and use of live donors for retransplantation.The etlucal considerations and objections to LDLT will be reviewed, as well as the future role of LDLT in liver transplantation.
Subject Misquoted.
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Advantages and Disadvantages of Neonatal Circumcision
Authors: Dennis Harrison
Journal: JAMA (1997)

<h3>To the Editor.</h3> —Dr Laumann and colleagues<sup>1</sup>conclude that data from the National Health and Social Life Survey do not lend clear support to either side in the circumcision debate. However, by demonstrating that circumcision does not reduce the risk of contracting STDs, the authors may have knocked another prop out from under a medical procedure that already depends on the frailest of support. Moreover, their finding that removal of the foreskin alters patterns of sexual behavior over a lifetime casts further doubt on the appropriateness of circumcising infants too young to give informed consent. Circumcision is an invasive procedure that is not essential to an infant's welfare and virtually always can be deferred with little or no risk. The finding that circumcision has significant impact in later life adds further credibility to the view that a decision regarding circumcision should be postponed until a man can choose for himself. In 1995
Reflections on the Pathologic Physiology of Atherosclerosis
Authors: Theodore B. Van Itallie, William C. Felch
Journal: New England Journal of Medicine (1960)

The Serum LipidsOf the three major classes of nutrients, amino acids (protein), glucose (carbohydrate) and fatty acids (fat), only the fatty acids present a problem in water solubility.28 To be able to absorb, transport and utilize fatty acids and other lipids, man has had to evolve rather elaborate (and vulnerable) mechanisms for making these water-immiscible or hydrophobic materials compatible with a system whose basic common medium is water. Indeed, for biochemical changes to occur, it is usually necessary for the reacting substances to be in solution in the same medium.The mechanisms used to deal with the water-insoluble fatty . . .
Letter: MSG
Journal: JAMA (1975)

<h3>To the Editor.—</h3> The letter by Bartoshuk et al (230:670, 1974) on the saltiness of monosodium glutamate (MSG) and sodium intake is so erroneous in conception and experimental design that corrective information must be brought to readers ofThe Journal. The authors assume that MSG is used to enhance the various single components of taste, in this case, perception of saltiness. This is untrue. The function of MSG as a flavor enhancer appears to be that of blending and bringing out those flavors naturally present in food.<sup>1,2</sup>In the Orient, glutamate is used at markedly higher levels than those employed in the United States because a fifth basic taste of glutamate is desired. However, to Occidental taste preferences, the levels employed to create a unique glutamate taste are considered unpalatable. Monosodium glutamate has been and is used by persons wishing to reduce sodium intake, as it is synergistic with
Hysterical Personality
Authors: Nancy C. Andreasen
Journal: JAMA (1978)

If not the oldest diagnostic category in the history of psychiatry, hysteria is certainly<i>one</i>of the oldest. The first chapter in this book, written by historian Ilza Veith, chronicles the changing concepts of hysteria and points to some crucial unanswered questions: Is hysteria a disorder limited to women, or does it occur in men? How do manifestations in men differ, or do they? How prevalent is it? Is it familial? If familial, is it learned through modeling, is it genetically transmitted, or is it multifactorial? What is the typical course? What are the typical complications? Why have the florid symptoms observed by Charcot or Freud become increasingly uncommon? What treatment approaches are most effective? Why? This book does not provide answers for most of these questions. In part, they are unanswerable, because definitive research on hysteria has not as yet been completed. Apart from that unavoidable weakness, however, this
PTH-088 Incidental Diagnosis of Inflammatory Bowel Disease in a British Bowel Cancer Screening Cohort: A Multi-Centre Study
Authors: R O Butcher, S J Mehta, O F Ahmad, C A Boyd, R Anand, J Stein, A M Abbasi, R George, R C Prudham, R Vega, S McCartney, S L Bloom, J K Limdi
Journal: Gut (2013)

<h3>Introduction</h3> The UK Bowel Cancer Screening Programme (BCSP) was launched in 2006 to cover the entire population of England and Wales. It screens individuals aged 60–69 years with a Faecal Occult Blood test (FOBt) followed by a screening colonoscopy if FOBt positive. We aimed to quantify the incidental diagnosis of Inflammatory Bowel Disease (IBD) and patient outcome in this cohort. <h3>Methods</h3> A retrospective review of BCSP outcomes was conducted from launch in February 2007 to August 2012. Screening data included patients invited, number screened (FOBt “normal” or “abnormal”) and colonoscopies performed. In those diagnosed with IBD at colonoscopy confirmed on histology, clinical data (demographics, disease characteristics, treatment and outcome) were obtained from case note and electronic record review. <h3>Results</h3> Of 477,553 patients invited, 219,705 were screened, representing an uptake of 46.01% and FOBt positivity of 2.35%. Colonoscopy was performed in 5350 patients (female 2287). Polyps were detected in 2344 (39.86%), cancer in 339 (5.77%) and 1383 (23.52%) had a normal examination. Endoscopic appearance suggestive of IBD in 112 patients was confirmed at histology in 66. Eleven patients were excluded as the diagnosis of IBD preceded screening. Twenty-one of 55 incidental cases were female. Median age at diagnosis was 64. Sixteen patients had Crohn’s disease (CD), 33 ulcerative colitis (UC) and 6 had IBD-type unclassified (IBDU). Follow-up data was available in 42 patients (mean follow-up 23.9 months). Twenty patients (47.6%) were asymptomatic at diagnosis. Seven (35.0%) of the asymptomatic patients became symptomatic during the follow-up period. Treatment included steroids (11), 5-ASA (34), immunomodulators (azathioprine 6; methotrexate 1) and anti- TNF (infliximab 2; adalimumab 1). None required surgery. In those requiring escalation of therapy (14.3%) the median time to immunomodulation was 21 months (range 5–30 months). Those requiring immunomodulators and/or anti-TNF therapy (male 4; female 2) had asymptomatic extensive UC, symptomatic left-sided UC, symptomatic left- sided IBDU, symptomatic Crohn’s colitis and symptomatic stricturing terminal ileal CD (2) at diagnosis. <h3>Conclusion</h3> An incidental diagnosis of IBD is not uncommon. With the advent of bowel cancer screening this number is set to increase. A proportion of these patients demonstrate rapid disease progression. Such patients may present an important model for study of early disease with novel insights and evolving treatment paradigms. <h3>Disclosure of Interest</h3> None Declared.
Acellular and whole-cell pertussis vaccines in Japan: report of a visit by US scientists
Authors: J. D. Cherry
Journal: JAMA (1987)

The report of the Public Health Service's Interagency Group to Monitor Vaccine Development, Production, and Usage published in this issue ofThe Journal<sup>1</sup>as well as the recent (Sept 22 to 24,1986) workshop on acellular pertussis vaccines in Bethesda, Md, sponsored by the same group, have provided valuable information about Japanese acellular pertussis vaccines. Using the data presented in the government report and at that workshop as well as in recent US studies<sup>2-4</sup>of a diphtheria and tetanus toxoids and pertussis vaccine (DTP) with a Japanese acellular pertussis component, we will review what could be expected if acellular pertussis vaccines were to replace whole-cell vaccines in the United States. The available data indicate that fever (both in frequency and degree) and other common systemic reactions such as fretfulness, anorexia, vomiting, and drowsiness will be less common with the use of acellular pertussis vaccines. Although local reactions of some
Backyard Barbecue Syndrome
Authors: Eddy D. Palmer
Journal: JAMA (1976)

IN MOST parts of the country these days, the receding winter snows are being followed by the scurry of amateur barbecuers setting up for the summer's annual atavistic backyard rituals. Most wives would agree that the family's nutritional status will suffer the next few months, but the pleasant social benefits far outweigh such matters. So, once again the season of the backyard esophageal steak impaction is on us. The setup is favorable for generating in a piece of steak the qualities that encourage it to catch in and plug the esophagus. First, whether intended or not, the steak is usually overcooked in such a way that the outside is hard, crusted, and incapable of being effectively masticated. Then, there is usually much beer, lots of good company, and plenty of talk and excitement—all effective deterrents to the attention required for efficient chewing. More important is the steak barbecuer's pernicious habit
儿童特应性皮炎的疾病轨迹
Authors: A.D. Irvine, P. Mina‐Osorio
Journal: British Journal of Dermatology (2019)

湿疹(也称为特应性皮炎或 AD)是一种复杂的皮肤病,通常在儿童早期发病,全世界 15% 至 20% 的儿童患此病。尽管它在某些儿童中会自行消退,但在许多儿童中,它会持续到成年期,这与普遍的看法相反。许多儿童患相关的过敏性疾病,例如哮喘、过敏性鼻炎和嗜酸性食管炎(食管的过敏性炎症),这是一种称为“特应性进程”的患病途径。爱尔兰和美国的作者旨在通过对大型患者队列(研究组)中开展的几项近期研究进行调查,从而找到可再现的模式(即临床相关特征),以帮助医生预测儿童期 AD 是否会消退或是进展。这些研究表明,实际上大多数特应性疾病的儿童患者并不遵循经典的“特应性进程”模式,而是遵循各种疾病过程。尽管数据来自不同来源或以不同的方式描述,但作者确定了儿童早期 AD 的共同特征,可以帮助估计持续性疾病(即进展至成年期)和相关过敏性疾病的风险。他们发现,在幼年时患重度 AD 的儿童以及父母有相关病史的儿童中,疾病进展的风险更高。遗传因素、过敏和居住在城市环境中也增加这种风险。作者提供了执业医师指南,可以帮助医生确定疾病进展风险较高的 AD 儿童患者,并确定最佳治疗方法,例如定期检查或将其转诊给专科医师进行进一步检查或治疗。
The Pathology, Diagnosis, and Treatment of Cardiac Diseases
Authors: W. O. Markham
Journal: BMJ (1859)

friction of his bodyr with cod-liver oil was employed; and he lay constantly in a flannel dress, kept saturated with the oil.In a few days after the adoption of this treatment, he began to revive, and convalesced rapidly.He was kept in the hospital three or four weeks lonaer than was at all necessary for the cure, and was at last discharged, in a plump healthy condition of body, on August 9th.CASE ii.John J., aged 16, was sent up from the same place on September 29th, to undergo a similar operation, and fell under the care of the same surgeon.He had suffered from symp- toms of stone for twelve years, and was extremely emaciated.It was at first determined to allow a week or two to elapse be- fore the proceeding, in order that the boy might become habituated to the air and system of the hospital; but it was shortly found expedient to operate at once, the boy's sufferings at each movement in bed and effort to pass uline rendering life muiserable to him.A large mulberry calenlus, weighing six drachms and twenty grains, was accordingly extracted, through a remarkably narrow snibpubic arch, on October 3rd.The boy got well quickly, and went out of the hospital of his own accord, cured, on the 28th of the same month.
Altered folate metabolism in early HIV infection
Authors: S. M. Tilkian
Journal: JAMA (1988)

<h3>To the Editor.</h3> —The letter in the Jan 22/29 issue of<i>JAMA</i>entitled "Altered Folate Metabolism in Early HIV [human immunodeficiency virus] Infection"<sup>1</sup>is interesting, since the authors state that the elevated folate levels observed in the majority of their patients were unlikely to have resulted from dietary supplementation. A related letter entitled "Folate Deficiency and Demyelination in AIDS [acquired immunodeficiency syndrome]" by Smith et al<sup>2</sup>appeared in the July 25, 1987, issue of<i>Lancet</i>. The authors reported that, although serum and erythrocyte folate levels could be normal, cerebrospinal fluid folate levels were low. Defective folate metabolism is known to cause multifocal perivenular demyelination like that due to vitamin B12 deficiency. We would like to point out that in vitamin B<sub>12</sub>deficiency, serum folate levels, measured as 5-methyl tetrahydrofolate, are elevated because vitamin B<sub>12</sub>is needed for the demethylation of 5-methyl tetrahydrofolate; in its absence, no
Coronary Aneurysms
Authors: J. C. Burne, J. Hart
Journal: BMJ (1960)

Musician9s dystonia is a task-specific dystonia that usually affects the embouchure or the most active digits of the most active hand, and therefore differs between instruments. Since it is usually painless and intermittent, the diagnosis is often delayed and it is commonly misdiagnosed as being an overuse disorder or tendon pathology. It arises from pathological brain plasticity: physiological studies suggest that it is an exaggeration of brain changes that are required to achieve advanced musical skills. Its treatment often has limited success; however, musical retraining, botulinum toxin or rehabilitation based on modifying the aberrant plasticity may help.
Error in Table in: Communication and Medication Refill Adherence: The Diabetes Study of Northern California
Journal: JAMA Internal Medicine (2013)

Neda Ratanawongsa, MD, MPH; Andrew J. Karter, PhD; Melissa M. Parker, MS; Courtney R. Lyles, PhD; Michele Heisler, MD, MPA; Howard H. Moffet, MPH; Nancy Adler, PhD; E. Margaret Warton, MPH; Dean Schillinger, MD
Hyperbaric oxygen therapy
Authors: P. S. Grim
Journal: JAMA (1990)

Hyperbaric oxygen therapy involves intermittent inhalation of 100% oxygen under a pressure greater than 1 atm. Despite over a century of use in medical settings, hyperbaric oxygen remains a controversial therapy. The last 20 years have seen a clarification of the mechanism of action of hyperbaric therapy and a greater understanding of its potential benefit. However, despite the substantial evidence that hyperbaric oxygen may have a therapeutic effect in certain carefully defined disease states, many practitioners remain unaware of these findings or are concerned about using hyperbaric therapy because of the controversy it has engendered. This review examines the indications currently considered appropriate for hyperbaric oxygen and briefly evaluates animal and clinical data substantiating these indications. Areas in which the mechanism of action of hyperbaric oxygen is still not well understood, as well as possible new areas of applications, are discussed. (<i>JAMA</i>. 1990;263:2216-2220)
Breast Cancer and Pesticides in Hawaii: The Need for Further Study
Authors: Ruth H. Allen, Michelle Gottlieb, Eve Clute, Montira J. Pongsiri, Janette Sherman, G. Iris Obrams
Journal: Environmental Health Perspectives (1997)

Only 30% of all breast cancer can be explained by known risk factors.Increases in breast cancer incidence rates in Hawaii over the past few decades cannot be attributed solely to improvements in screening and detection.Avoidable environmental factors may contribute to a proportion of the unexplained cases.Emerging evidence on endocrine disruption suggests that environmental chemicals may play a role in the development of breast cancer.Agricultural chemicals, including endocrine disruptors, have been used intensively in Hawaii's island ecosystem over the past 40 years leaching into groundwater, and leading to unusually widespread occupational and general population exposures.This paper discusses breast cancer patterns in Hawaii in the context of documented episodes of exposure to two endocrine-disrupting chemicals, chlordane/heptachlor and 1,2-dibromo-3-chloropropane (DBCP), at levels that sometimes exceeded federal standards by several orders of magnitude.In light of this history, detailed geographic-based studies should be undertaken in Hawaii to elucidate the potential role of environmental factors in the development of breast cancer and other diseases.
Pathologic complete response rates after neoadjuvant chemoradiation (CRT) for rectal cancer: Do novel agents have a role?
Authors: Muhammad Shaalan Beg, Jeffrey Meyer, Glen C. Balch, Xian-Jin Xie, Amit G Singal
Journal: Journal of Clinical Oncology (2012)

597 Background: Preoperative concurrent radiation with either 5-fluorouracil (5FU) or capecitabine (CAP) is considered standard of care for T3-T4 and/or node positive rectal cancers with historical pathological complete response (pCR) rates ranging from 7-29%. There is lack of randomized data on the incorporation of bevacizumab (B) and cetuximab (C) with neoadjuvant chemoradiation (CRT). The aim of our study was to quantify pCR and adverse event rates for B-CRT and C-CRT in patients with rectal cancer. Methods: A systematic literature review using the Medline database and national meeting abstracts identified trials incorporating bevacizumab and cetuximab for neoadjuvant chemoradiation between 2000 and 2011. Pooled rates of pCR and frequency of grade 3-4 adverse events per patient with 95% confidence intervals (CI) using the adjusted Wald method, were calculated. Results: Out of 24 trials identified, 15 trials with a total of 457 (range 8-61) patients incorporated B-CRT. Five studies used 5FU, ten used CAP. A third chemotherapeutic agent was also included in 7 trials of B-CRT. There were 9 trials incorporating C-CRT with a total of 332 (range 20-50) patients. Two studies used 5FU, 7 used CAP, while four studies also included a third therapeutic agent. The pooled pCR rate for B-CRT of 20.8% (95% CI 17.3-24.8), was significantly higher than the 9.6% (95%CI 6.92-13.2) pCR rate for C-CRT (p &lt; 0.001). The rate of grade 3-4 adverse events was significantly lower for B-CRT at 0.38 per patient studied (95% CI 0.34-0.43) compared to C-CRT at 0.55 per patient (95%CI 0.49-0.60) (p&lt;0.001). Surgery was performed in 92% of B-CRT and 94% of C-CRT patients. Conclusions: The addition of either B or C to conventional neoadjuvant CRT does not appear to yield higher pCR rates than those reported with conventional CRT alone. There is insufficient evidence to support routine use of novel agents in this treatment strategy for rectal cancer. Interestingly, although surgical rates are high in both groups, C-CRT has significantly lower rates of pathologic complete response and significantly higher rates of toxicity than B-CRT.
THE PULSE RATE AND METABOLISM
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal