tbuckley/cabot-search huggingface dataset:
541 Prevalence of hepatitis C in France, 2003–2004
Authors: C. Metfre, Y. Le Strat, E. Delarocque-Astagneau, J.F. Meyer, D. Coste, J. Steinmetz, E. Dubois, D. Antona, J. Warszawski, S. Leiser, J.P Giordanella, R. Gueguen, A. Landaus, J.C. Desenclos
Journal: Journal of Hepatology (2006)
Methyprylon-induced bone marrow suppression in siblings. An inherited defect?
Authors: G. D. McLaren
Journal: JAMA (1978)

Transient bone marrow suppression in two sisters followed ingestion of the sedative-hypnotic drug methyprylon. No other pharmacologic or environmental inciting factor common to both patients was identified. The mechanisms responsible could not be defined; abnormal suppression fo granulocyte progenitors by the drug in vitro was not demonstrable. It is postulated that a pharmacogenetic interaction may have been responsible for methyprylon-related bone marrow suppression in these two siblings.
CASE OF DERODIDYMUS (DICEPHALUS)
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 2075: MAPK pathway expression in platinum-treated cancers
Authors: Rebecca A. Georgiadis, Amy Stark, Amanda B. Hummon
Journal: Cancer Research (2019)

Abstract The Mitogen-Activated Protein Kinase (MAPK) Pathway is a critical cell signaling pathway in normal cell function. It is involved in cell proliferation, cell survival, and differentiation. It is a common pathway that is mutated in many cancers, and drug targets have already been developed and tested in clinical trials for many components of this pathway. Further understanding of how gene expression in this pathway is altered by treatment of chemotherapeutic agents can potentially impact resistance to chemotherapeutic agents. The half-maximal inhibitory concentration (IC50) was found for A549 cultured lung adenocarcinoma cells treated with cisplatin and for DLD1 cultured colorectal adenocarcinoma cells and HCT116 colorectal carcinoma cells treated with cisplatin and oxaliplatin. The IC50 concentration of cisplatin-treated A549 cells was 5.429 µM, of DLD1 cells was 5.017 µM, and of HCT116 cells was 4.42 µM. The IC50 concentration of oxaliplatin-treated DLD1 cells was 37.53 µM, as compared to 10.36 µM for HCT116 cells. Therefore, the HCT116 cell type is more sensitive to both chemotherapies. qPCR was then conducted on platinum-treated A549 cultured cells, DLD1 cultured cells, and HCT116 cultured cells to evaluate expression of 6 MAPK pathway genes: RAF1, MAP2K1, MAPK1, STAT1, CREB1, and LAMTOR3. A different pattern of induced gene expression was observed across all three cell types. The 24 hour time point of cisplatin-treatment of A549 cells demonstrated a consistent upregulation of expression in all genes, which is starkly contrasted with a significant downregulation at the 48 hour time point. In HCT116 cells, cisplatin treatment led to the opposite trend, as there was downregulation at the 18 hour time point and significant upregulation at the 48 hour time point. DLD1 had inconsistent results. This demonstrates that level of expression of genes in the pathway is cell-type dependent and time-dependent. Naringenin is a flavonoid that has been implicated in MAPK signalling. We tested this compound as an inhibitor to determine the effect on platinum induced gene expression in lung and colorectal cells. These results have implications for treatment of multiple cancers, especially lung and colorectal cancer. Citation Format: Rebecca A. Georgiadis, Amy Stark, Amanda B. Hummon. MAPK pathway expression in platinum-treated cancers [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2075.
Commentaire de travail de E. Dubcenco et al., pp. 971
Journal: Endoscopy (2009)

See also: Adhesion formation after peritoneoscopy with liver biopsy in a survival porcine model: comparison of laparotomy, laparoscopy, and transgastric natural orifice transluminal endoscopic surgery (NOTES)Endoscopy 2009; 41(11): 971-978DOI: 10.1055/s-0029-1215229
Blood Lead Levels Among Children in a Managed-Care Organization— California, October 1992-March 1993
Journal: JAMA (1995)

Despite substantial progress in reducing exposures to lead among children, as recently as 1991, 9% of children in the United States had blood lead levels (BLLs) of > or = 10 micrograms/dL (1)--levels that can adversely affect intelligence and behavior. In 1991, CDC recommended screening all children for lead exposure except those residing in communities in which large numbers or percentages previously had been screened and determined not to have lead poisoning (2). Subsequently, the California Department of Health Services (CDHS) issued a directive to all California health-care providers participating in the Child Health and Disability Prevention Program to routinely screen children for lead poisoning in accordance with the 1991 CDC guidelines (3). This report presents finding of BLL testing during 1992-1993 from a managed-care organization that provides primary-care services to Medicaid beneficiaries in several locations in California (i.e., Los Angeles County, Orange County, San Bernardino County, Riverside County, Sacramento, and Placerville).
The yield from pelvic endoscopy. Comparison of culdoscopy and laparoscopy
Authors: J. W. Harris
Journal: JAMA (1971)

Richly supplied with nerves and uniquely subject to hormonal and gestational changes, the female pelvic structures often are associated with pain and tumor formation. Examination under anesthesia, culdocentesis, and colpotomy have been the classical methods of diagnosis. More recently, endoscopic procedures have improved the accuracy of evaluating the uterus, fallopian tubes, and ovaries. This study compares 45 patients who underwent culdoscopy and 40 who had laparoscopy performed. Seventy-six of these had pelvic pain or tumor; the remainder, a variety of more obscure symptoms referable to the pelvis. The indications for use of the two procedures confirm the panoramic view of the pelvis obtainable with the laparoscope. In cases requiring a thorough evaluation of all pelvic structures, the conclusion is reached that laparoscopy is the more useful technique.
Progress Toward Poliomyelitis Eradication—Democratic Republic of Congo, 1996-1999
Journal: JAMA (2000)

In 1988, the World Health Assembly resolved to eradicate poliomyelitis by December 31, 2000 (1). Although progress has been extraordinary (2), full implementation of polio eradication strategies has been delayed in several countries affected by war. The Democratic Republic of Congo (DRC) has experienced continual armed conflict since October 1996. As a result, DRC is the last country in the African Region of the World Health Organization (WHO) to implement National Immunization Days (NIDs*). DRC is an important global reservoir for wild poliovirus and shares more than 5580 miles (9000 km) of border with nine countries; in at least seven of these countries polio is endemic. The large area of DRC, substantial amount of poverty, weak health-care infrastructure, poor transportation and communication, and competing demands for resources present considerable challenges to polio eradication. This report summarizes information on the existing health-care infrastructure and routine coverage, information from NIDs carried out in 1999, and results from the recently established surveillance system for acute flaccid paralysis (AFP).
Eosinophilic gastritis
Authors: G. J. Culver
Journal: JAMA (1967)

INFLAMMATORY CHANGES with eosinophilic infiltration of the walls of the gastrointestinal tract may occur in two forms. One is a circumscribed polypoid lesion, and the other consists of a diffuse infiltrative thickening of the walls. The former has been called in general eosinophilic granuloma,<sup>1-3</sup>and in the specific case of the stomach has been described as inflammatory fibroid polyps<sup>4</sup>and gastric fibroma with eosinophilic infiltration.<sup>5</sup>This form is not usually associated with blood eosinophilia or an allergic history. The diffuse type has been recorded in the literature under such names as eosinophilic granuloma,<sup>6</sup>eosinophilic gastroduodenopathy,<sup>7</sup>eosinophilic gastroenteritis,<sup>2,8</sup>and in the specific case of the stomach as eosinophilic gastritis,<sup>9</sup>gastric lesion of Loeffler's syndrome,<sup>10</sup>eosinophilic linitis plastica,<sup>11</sup>and gastric granuloma with eosinophilic infiltration.<sup>12</sup>This type is commonly associated with blood eosinophilia and an allergic history. Both forms have been described as
Archives of Ophthalmology, Chicago
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reply
Authors: Gisa Tiegs, Gabriele Sass
Journal: Hepatology (2005)

For both studies published in HEPATOLOGY,1, 2 we used biliverdin IX dihydrochloride (Formula C33H34N4O6 × 2HCl) from ICN Biomedicals Inc., not, as it was indicated, from Sigma Chemicals. We apologize for this mistake, which we overlooked in Materials and Methods, and thank HEPATOLOGY for giving us the opportunity to correct this. ICN Biomedicals Inc. now sells this product under the name of MP Biomedicals, LLC (Ohio, USA; available under Cat. no. 194886). This substance from ICN was commonly used when investigating effects of HO-1 products in vivo and exerted biological and protective effects not only in our hands.3, 4 According to its data sheet, it passed the identity test and was about 95% pure. We actually did not perform thin-layer chromatography of any batch of the biliverdin IX dihydrochloride used in our experiments but instead relied on the description of ICN regarding identity and purity. Biliverdin IX dihydrochloride was dissolved in saline, kept in the dark at anytime, and applied to mice at 25 mg/kg in a volume of 200 μL intraperitoneally. As controls for the activity of biliverdin IX dihydrochloride we used heat- and light-inactivated aliquots in parallel groups of mice to rule out, for example, lipopolysaccharide effects or effects of other unknown contaminants. We did not add any ingredients, which were not indicated in the manuscripts, to increase solubility. In our hands, solubility was good enough to inject mice using a 0.4-mm diameter needle. The experiments described in our manuscripts were repeated several times and gave consistent results. Regarding the controls used, we feel that the readers of HEPATOLOGY do not have to fear that we or others presented a Gigo effect by using biliverdin IX dihydrochloride. Furthermore, as suggested by McDonagh, effects of biliverdin in vivo might be even stronger than observed so far. Gisa Tiegs*, Gabriele Sass*, * University of Erlangen, Department of Pharmacology and Toxicology, Erlangen, Germany.
What's new in the other general journals
Authors: Kristina Fister
Journal: BMJ (2006)

A study from India reports that the prevalence of smoking among primary school students (aged 10-16) in two cities, Delhi and Chennai, is two to four times as high in sixth grade students than in eighth grade students. The cross sectional survey, with a response rate of over 90%, included more than 11 000 students from governmental and private schools. Overall, nearly 15% of students had ever used tobacco and almost 5% were current users. The prevalence was significantly higher among boys than girls (17% v 11%), governmental schools than private schools (17% v 11%), and sixth graders than eighth graders (25% v 9%). Young adolescents are particularly likely to internalise messages from society, say the authors. India is a leader in global tobacco control and prohibits all direct and indirect advertising of tobacco products, smoking in public places, sales of tobacco products to people under 18, and sales of tobacco products near educational institutions. The findings in this survey suggest, however, that young urban teenagers are starting to use tobacco at increased rates. Since early use of tobacco predicts greater likelihood of addiction, longer lifetime use, and higher rates of lung cancer, these findings are important to public health. Lancet 2006;367: 589–94 [OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] Rimonabant, a selective cannabinoid-1 receptor blocker, could be a novel aid in treating obesity. In the RIO-North America double blind controlled trial, researchers randomised 3045 overweight or obese people to placebo, 5 mg per day of rimonabant, or 20 mg per day of rimonabant for one year, all in addition to diet and exercise. After one year, people receiving rimonabant were randomised to placebo or continued with the same dose of rimonabant during year two. People who were taking 20 mg of rimonabant lost more weight than those in the control group (6.3 (SE 0.2) kg v 1.6 … [1]: {openurl}?query=rft.jtitle%253DLancet%26rft.stitle%253DLancet%26rft.aulast%253DReddy%26rft.auinit1%253DK.%2BS.%26rft.volume%253D367%26rft.issue%253D9510%26rft.spage%253D589%26rft.epage%253D594%26rft.atitle%253DDifferences%2Bin%2Btobacco%2Buse%2Bamong%2Byoung%2Bpeople%2Bin%2Burban%2BIndia%2Bby%2Bsex%252C%2Bsocioeconomic%2Bstatus%252C%2Bage%252C%2Band%2Bschool%2Bgrade%253A%2Bassessment%2Bof%2Bbaseline%2Bsurvey%2Bdata.%26rft_id%253Dinfo%253Adoi%252F10.1016%252FS0140-6736%252806%252968225-1%26rft_id%253Dinfo%253Apmid%252F16488802%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1016/S0140-6736(06)68225-1&link_type=DOI [3]: /lookup/external-ref?access_num=16488802&link_type=MED&atom=%2Fbmj%2F332%2F7539%2F477.atom [4]: /lookup/external-ref?access_num=000235397800033&link_type=ISI
Pseudotuberculosis.
Authors: None H.
Journal: JAMA (1899)

London, Eng., May 1, 1899. <h3>To the Editor:</h3> —This is a subject, allusions to which are frequent in medical literature. These, however, are essentially of the vaguest and most academic character and the general impression to be gained from them is that such a disease exists much more commonly than we usually suspect, and is frequently mistaken for genuine tuberculosis. These impressions were, however, completely dissipated by the interesting discussion which recently occupied two successive sessions of the London Pathological Society. In the first place it was shown that there is no such single or distinct disease, but that the name applies to a number of conditions which agree only in one respect, that they imitate more or less completely the anatomic picture of tubercle postmortem; clinically, there is little or no resemblance whatever between themselves, or to the "genuine" form. This "anatomic tubercle" may be due to a number
INJECTION OF THE BILE DUCTS WITH BARIUM
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An Odor of Smoke
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MODERN THERAPEUTICS.
Authors: WARREN B. HILL
Journal: JAMA (1900)

There is no field in medicine that presents such opportunities for exploration as therapeutics. There is none in which so much work has been done and none where such results may be expected. Therapeutics is being revolutionized. The biologic laboratory has become one of the important factors in the production of our remedies. It not only furnishes us with the various serums and animal extracts now so universally used, but it also affords us a means of standardizing vegetable products so that the very best results may be attained. The most marked advance in therapeutics is shown by its tendency toward rationalism, and while empiricism, pure and simple, is necessarily giving way before the light of reason, we do not underestimate the value of clinical experience, when applied to a working hypothesis. It was but yesterday we were content to study the pathologic conditions in diseases as demonstrated in the
The uncertain consequences of formaldehyde toxicity
Authors: R. E. Yodaiken
Journal: JAMA (1981)

FOR MANY years, pathologists and their assistants have been crying over formaldehyde in much the same way as cooks cry over onions. Itchy eyes, a running nose, browning or blistering of the fingers,<sup>1</sup>and coughing and respiratory distress (even to the point of acute pulmonary congestion with edema)<sup>2</sup>has been the lot of pathologists, their residents, and their assistants. Formaldehyde toxic reactions have been an accepted part of the profession, whether one hovers over the cutting board with biopsy specimens or takes "pickled" organs out of the earthenware containers for student demonstrations. Fume-filled anatomy rooms and pathology museums have been a part of the medical student's heritage. Now all that may be rapidly on its way out. Why the sudden concern to put specimens under hoods, to find ways of flushing out preparation rooms to rid them of the formaldehyde residues, to ventilate storage rooms, and to use
THE DEPARTMENT OF PUBLIC HEALTH.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Too many deaths from diarrhea
Authors: J. Snyder
Journal: JAMA (1988)

The report by Ho and colleagues<sup>1</sup>in this issue ofThe Journalprovides disturbing data on the mortality associated with diarrhea in the United States and raises two important issues for consideration. The magnitude of the deaths reported, an average of approximately 500 children (400 of whom are infants) each year, is troubling because effective therapy is widely available to treat acute diarrhea. As the authors reasonably ask, are these preventable deaths? An even more disturbing issue is the greatly increased rate of diarrheal deaths among black children. In considering the magnitude of the deaths and possible interventions, information about the duration of diarrhea, the nature, amount, and duration of therapy used, and the access to and utilization of health facilities is required. Because this study was a retrospective review of mortality surveillance data, only partial information on these factors is available. At least two thirds of the deaths