tbuckley/cabot-search huggingface dataset:
Weight control and exercise. Cardinal features of successful preventive gerontology
Authors: W. R. Hazzard
Journal: JAMA (1995)

The concept of "successful aging"<sup>1</sup>is based on application of the principles of effective "preventive gerontology"<sup>2</sup>: personal investments in healthy living coupled with societal investments in a safe and healthful environment. When pursued to its logical end, preventive gerontology should prolong the period of middle-age vigor to advanced old age and (it is hoped) reduce the burden and duration of chronic disease, disability, and dependency that often precede "natural death."<sup>3</sup>This model of successful aging remains widely debated, however, principally as to whether its optimistic outcome fairly represents the future for our aging population (or, grimly, whether the opposite scenario might actually occur, ie, a prolonged period of decline, disability, and dependency before a lingering death). In the 15 years since the debate was framed by Fries,<sup>3</sup>researchers have been working to generate the data that can rationally inform the argument. One such study that significantly
Mark Fernell
Journal: BMJ (2005)

Founder of the modern hospice movementCicely Saunders founded the first modern hospice and, more than anybody else, was responsible for establishing the discipline and the culture of palliative care.She introduced effective pain management and insisted that dying people needed dignity, compassion, and respect, as well as rigorous scientific methodology in the testing of treatments.St Christopher's Hospice opened in south west London in 1967.It is now one of many but is still the leader in the field.It was her personal achievement and has been imitated all over the world.She raised the funds for the hospice and contributed some of her own money.Saunders introduced the idea of "total pain," which included the physical, emotional, social, and spiritual dimensions of distress.A good listener, she paid systematic attention to patient narratives.One St Christopher's patient, transferred from another hospital, said, "They used to see how long I could go without an injection.I used to be pouring with sweat because of the pain.I couldn't speak to anyone and I was having crying fits.I think I've only cried once since I've been here . . .The biggest difference is feeling so calm.I don't get worked up or upset."Cicely Mary Strode Saunders was born in Barnet, Hertfordshire, in 1918.She was sent to Roedean School when she was 10.Taller than the other girls, she felt she never fitted in, which, she said, gave her a feeling for people who were outsiders.She also suffered from a painful and slightly crooked spine, and was made to lie flat on the floor for 40 minutes a day.Her father disapproved of her desire to be a nurse, and so instead she went to study at Oxford.After the outbreak of the second world war she abandoned her course and defied her parents' advice, enrolling as a student nurse at St Thomas' Hospital in 1944.However, her back was still painful, and she was advised to quit nursing.After returning to Oxford for a year she gained a "war degree" and qualified as a social worker, or what was then called a lady almoner, in 1947.Saunders was originally an agnostic, but, while on holiday in Cornwall with some
THE MECHANISM OF ANTIGEN-ANTIBODY REACTIONS
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Journal of Surgical Research, Philadelphia
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dosage of Nor-Epinephrine
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prevalence of Cholesterol Screening and High Blood Cholesterol Among Adults—United States, 2005, 2007, and 2009
Journal: JAMA (2012)

High blood cholesterol is a leading risk factor in the development of atherosclerosis and coronary heart disease (CHD). The risks associated with high blood cholesterol can be reduced by screening and early intervention. Current clinical practice guidelines provide evidenced-based standards for detection, treatment, and control of high blood cholesterol. Healthy People 2020 monitors national progress related to screening and controlling high blood cholesterol through the National Health Interview Survey and the National Health and Nutrition Examination Survey (NHANES). State-level estimates of self-reported cholesterol screening and high blood cholesterol prevalence are available using Behavioral Risk Factor Surveillance System (BRFSS) data. To assess recent trends in the percentage of adults aged ≥18 years who had been screened for high blood cholesterol during the preceding 5 years, and the percentage among those who had been screened within the previous 5 years and who were ever told they had high blood cholesterol, CDC analyzed BRFSS data from 2005, 2007, and 2009. The results of that analysis showed that the percentage of adults reporting having been screened for high blood cholesterol within the preceding 5 years increased overall from 72.7% in 2005 to 76.0% in 2009. In addition, the percentage who had ever been told they had high cholesterol increased from 33.2% to 35.0%. Both self-reported screening and high cholesterol varied by state and sociodemographic subgroup. To reach the Healthy People 2020 target for cholesterol screening, public health practitioners should emphasize the importance of screening, especially among younger adults, men, Hispanics, and persons with lower levels of education.
SNOBBERY IN FLAT OWNERS.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
JAMA Psychiatry
Authors: Phil Fontanarosa, Annette Flanagin, Brenda Gregoline, Tracy Frey, Miriam Cintron, Kevin Brown, Amanda Ehrhardt, Iris Lo, Suzanne Walker, Connie Manno, Sara Billings, Timothy Gray, Paul Ruich, Catherine Copyreaders, Stephanie Alden, Jane Beckmeyer, Jan Calayag, Mary Clavey, Paula Coerver-Connolly, Laura Glitman, Brandy King, Donna Patton, Editorial Thordsen, Wanda Assistant, Larry Bryant, Monica Mungle, Elaine Williams, Fanny Brown, Lenette Gardner-Gullens, Erin Kato, Peter Kim, Rachell Lozano, Michaela Mark, Caroline Sietmann, Elizabeth Scientifi, Michael Berkwits, Michelle Kurzynski, Eric Butkus, Carrie Butt, Mary Ferkaluk, Daniel Morrow, Reuben Rios, Ronna Henry, Karen Bucher, Andy Rekito, Emily Ling, David Song, Deputy Livingston, Thomas Cole, Marla Hall, Deanna Willis, Yolanda Davis, Joseph Thornton, Deanna Bellandi, Jim Periodical, Thomas Easley, Brian Shields, Karen Adams-Taylor, Monica Smith, Jeff Ery, J Bonistalli, Kathy Russell, Mirna Monal, Stacey Mchugh, Marketing Thornbury, Tricia Classifi, Thalia Moss, Susan Henning, Tiff Stevenson, Saskia Bolore, Gretchen Linder, Brian Mccartney, Christine Hearne, Rebecca Staff, David Baum, Natasha Nekola, Ron Marketing, Paul Gee, Elizabeth Solaro, Geoff Rey Flick, Rick Bell, Fergus Clare, Lindsay Dawson, Will English, Ellen Gibson, Mustafa Ishaq, Craig Mccaff Rey, Michael Mcgraw, Daniel Pickhardt, Romando Rossini, Stacy Business, Analyst Sirisha, Alluri Staff, Millette Jackson-Bates, Karl Elvin, Nancy Essex, Jaye Mize, Sean O'donnell, Sue Managers, David Antos, Chris Borden, Debbie Camp, Lydia Cruz, Scott Curl, Diane Darnell, Jordynn Farrar, Colleen Kelly, Chris Meyer, Annemarie Neff, J Neff, Sean Ohlson, Phil O'leary, Bill Pedone, Susan Price, Binita Shah, Denise Steinhauser, Erin Van Dusen, Joe Advertising, Production Services, Ahmed Avendano, Kim Boler, Rhonda Brown, Fin Carter, Daniel Degroot, Shawn Hansen, Euwanaha Joiner-Smith, Joshua Lane, Cindy Rendlen, Ellen Yoshihara, Circulation Services, Julie Burton, Noemi Rivera, Mary Sieck, Sarah Subramanian, Geneine Van, Someren Composition, New Media, Gail Barrett, Regina Brownlee, Amanda Camino, Brenda Chandler-Grayer, Emily Dunn, Amy Evers, Maleeka Holden, Teri Hutchison, Mary Kuranda, Joshua Lampinen, Nathan Mitre, Patricia Panek, La Son Diggs, Joe Amft, Maria Duda, Fred Furtner, Carolyn Hall, Maria Kowalkowski, Proofreading Carol, Joy Farrell, Daniel James, Judith Literskis, Teresa Omiotek, Michael Ryder, James Madara, Bernard Hengesbaugh, Dan Blazer, North Carolina, David Braff, La Jolla, Stephen California, Washington Dager, Atlanta Druss, Susan Georgia, New Essock, New York, Ellen York, James Frank, Maryland Harris, S Kenneth, Virginia Kendler, C Ronald, Kathleen Kessler, Maryland Merikangas, Judith Samples O'malley, Maryland Rapoport, F Charles, Myrna Reynolds, New Weissman, Charles York, St Zorumski, Shitij Kapur, Michael Owen, Fmed Sci, Naomi Wray, Roy Grinker Sr, Daniel Freedman, Jack Barchas, Joseph Coyle, Jennifer Urbano Blackford, Jennifer Laws, Woolf Nashville, Dost Öngür, Martin Paulus, Christine Konradi, Helena Chmura Kraemer, Palo Alto, Howard Bauchner
Journal: JAMA Psychiatry (2017)
Medicolegal
Journal: JAMA (1929)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Alpha-adrenergic mechanisms in myocardial ischemia.
Authors: G Heusch
Journal: Circulation (1990)

alpha-Adrenoceptor-mediated effects of sympathetic activation on the heart and coronary circulation are reviewed with emphasis on the pathophysiology of myocardial ischemia. A classification of alpha-adrenoceptor subtypes is presented, and the effects of alpha-adrenoceptor activation on presynaptic sympathetic nerve terminals, cardiomyocytes, endothelium, platelets, and coronary smooth muscle cells are discussed. alpha-Adrenergic coronary vasoconstriction at rest and during situations of sympathetic activation such as exercise and excitement is analyzed for the segmental, transmural, and regional distribution of coronary blood flow. Evidence for a significant contribution of alpha-adrenergic coronary vasoconstriction to experimental and clinical myocardial ischemia is provided. Cardiomyocyte alpha-adrenoceptor activation may be involved in ischemic and reperfusion arrhythmias. The participation of presynaptic and postsynaptic alpha-adrenoceptors, as well as of alpha 1- and alpha 2-adrenoceptors, in experimental and clinical myocardial ischemia will require further investigation.
Reply:
Authors: Masahiko Koda, Yoshikazu Murawaki
Journal: Hepatology (2007)

We are delighted that Halfon et al. provided external validation for FibroIndex. They proposed a problem in gamma globulin for the discrepancy between our study and their data. The importance of serum gamma globulin in chronic hepatitis C has already been reported by several investigators.1-3 Imbert-Bismut et al.1 reported that serum gamma globulin was higher in patients with F2 or F3 than in those with F0 or F1. Our other study series3 also revealed that serum gamma globulin values were quantitatively correlated with staging scores. Therefore, it leaves no doubt that serum gamma globulin reflects the hepatic fibrosis in chronic hepatitis C. Next, they point out that the measurement method of gamma globulin is not always reliable. We also emphasized the importance of the accuracy control of each parameter in the index comprising laboratory tests. In fact, we have described in the text that each parameter is under strict quality control. In our study, gamma globulin was measured using a single and dedicated analyzer with minimal interlaboratory variability (coefficient of variation at least <6%) as well as aspartate aminotransferase (AST) and platelet count. Although Halfon et al. do not show their quality control of gamma globulin measurement, this discrepancy may indicate the importance of the standardization and the strict quality control of each parameter. Indeed, AUROCs of APRI and Forns index conducted by AST and platelet in our study are higher than those in Halfon's study. Masahiko Koda*, Yoshikazu Murawaki*, * Second Department of Internal Medicine, Faculty of Medicine, Tottori University, Yonago, Tottori, Japan.
The role of ultrasonography in the diagnosis of the renal mass and impaired renal function
Authors: R. Rosenblatt
Journal: JAMA (1984)

MODERN ultrasonography provides important contributions to the evaluation of the renal mass and the diagnosis of impaired renal function. Awareness of the advantages and limitations of ultrasonography in the diagnosis of these frequently encountered urologic problems is essential if the performance of unnecessary diagnostic procedures is to be minimized and only relevant studies are performed. <h3>The Renal Mass</h3> An important diagnostic parameter relating to the renal mass (usually identified initially on intravenous urography [IVU]) concerns the consistency of such a mass—namely, whether it is fluid filled or solid. Since the ultrasonographic study is highly sensitive in detecting fluid, the diagnosis of a renal cyst can be made with an accuracy approaching 98%.<sup>1</sup>This information is particularly valuable in the treatment of patients with renal masses, since most masses are cysts and generally of no clinical importance. The incidence of asymptomatic renal cysts has been reported to be about 20%
Omission of a Definition
Journal: JAMA (2017)

Gonzalo Hernández, MD, PhD; Concepción Vaquero, MD; Laura Colinas, MD; Rafael Cuena, MD; Paloma González, MD; Alfonso Canabal, MD, PhD; Susana Sanchez, MD; Maria Luisa Rodriguez, MD; Ana Villasclaras, MD; Rafael Fernández, MD, PhD
INSPIRATORY DYSPNEA DUE TO PARALYSIS OF THE DILATORS OF THE NARES FOLLOWING ACUTE INFECTIOUS MENINGO-ENCEPHALITIS
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Myelodysplastic syndrome with erythroid hypoplasia/aplasia: A case report and review of the literature
Authors: Julio García‐Suárez, Teresa Pascual, M. Angeles Muñoz, Begoña Herrero, Ana Pardo
Journal: American Journal of Hematology (1998)

Myelodysplastic syndrome (MDS) with erythroid hypoplasia/aplasia has not yet been clearly defined, and in most patients it is mistaken for acquired pure red cell aplasia (PRCA).We report a patient with severe transfusion-dependent anemia (Hb 6.9 g/dl) and reticulocytopenia.WBC and platelet counts were normal.Bone marrow examination showed a marked trilineage dysplasia and a low percentage of erythroid precursors (3%).A diagnosis of MDS (refractory anemia according to FAB classification) with erythroid hypoplasia/aplasia was made.Repeated cytogenetic analysis of bone marrow showed normal karyotypes.Moreover, serial IgM serology and DNA analysis of the patient's sera for B19 parvovirus were negative.Other conditions known to be associated with erythroid aplasia were also absent.The patient failed hematinics and prednisone therapy.He next received r-HuEPO (200 U/kg three times weekly).This form of therapy achieved a rapid and complete erythroid response.He has remained in complete erythroid response after a 7-month period on maintenance therapy of 100 U/kg three times weekly.A review of the literature revealed only 15 well-documented cases of MDS with erythroid hypoplasia/aplasia.All had morphological evidence of myelodysplasia.These patients were predominantly elderly males, all required regular packed red cell transfusions, and had an unfavorable prognosis, mainly because of a high rate of blastic transformation (frequently preceded by a myeloproliferative phase).The mechanism of erythroid hypoplasia in this subgroup of MDS remains uncertain.However, laboratory and clinical data suggest the existence of an intrinsic stem cell defect.None of the patients received hematopoietic growth factors.To our knowledge, our patient is the first case of MDS with erythroid hypoplasia where r-HuEPO was successfully attempted.The description of more cases is necessary to delineate the value of r-HuEPO therapy in this rare variant of MDS.Am.
Local Anesthesia in Otolaryngology and Rhinology.
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal