tbuckley/cabot-search huggingface dataset:
The cancer syndrome
Authors: P. Rubin
Journal: JAMA (1974)

THE TERM syndrome is applied to a constellation of features that result in a recognizable pathologic and clinical symptom complex. It is an association of characteristics that often alert the physician that certain disparate physical findings or complaints may not be chance events. Furthermore, seemingly remote pathophysiologic occurrences may offer a clue about the pathogenesis of the neoplastic state. The increasing awareness of syndromes in cancer patients has allowed for new diagnostic and investigative pathways. The debilitation of a cancer patient may not be related to the invasion of normal and vital organs by the neoplasm, but to the tumor's capability to create or be causally related to certain distant functional aberrations. The patterns of production of such features are distinctive and should be known in their relationship to alimentary-tract growth. Most syndromes described in medicine are related to genetic factors, and are recognizable mainly through identifiable hereditary transmission patterns.
Abstract LB-248: A novel multiplex assay for detection and quantitation of fatty acid synthase (FASN) in serum or plasma samples
Authors: Neeraja Venkateswaran, William M. Nelson
Journal: Cancer Research (2019)

Abstract Many cancers overexpress FASN which catalyzes the final synthetic step of de novo fatty acid synthesis pathway. FASN has been considered as a potential drug target for several decades now. Many publications provide evidence of the elevated FASN with aggressive tumors, but still, there are very few inhibitors of FASN that have successfully been utilized as therapeutics in the clinical arena. An accurate measurement of FASN in association with tumor-specific markers in solid tumors and serum may help to propel forward the therapeutic significance of FASN inhibitors. With this objective in mind, we are currently working on the development of a multiplex assay for detection and quantitation of FASN and Cripto-1 in serum samples. We have optimized a magnetic fluorescent bead based multiplex sandwich immunoassay for detection and quantitation of FASN and Cripto-1 (CR-1) in human serum and plasma samples. We selected Cripto-1 to pair with FASN because it is an EGF-like domain carrying growth factor associated with a number of different types of human carcinomas. We use two different monoclonal antibodies for FASN and one for CR-1 as capture antibodies covalently coupled to magnetic fluorescent beads and a mixture of two biotin-labeled detection antibodies in this assay. The streptavidin-phycoerythrin (SAPE) conjugate is used to report the positive capture of a target in this assay. We have also included various internal controls in this assay to monitor the assay performance and assure quality of the reagents used in each well. The dynamic range of this assay was determined to be 100pg/mL to 100 ng/mL using recombinant FASN and Cripto-1 from commercial sources. The R2 values were 0.98 and above for each of the analytes and recovery of each standard were between 90 % and 125%. We spiked recombinant FASN and Cripto-1 in normal human serum and plasma at different concentrations and spike recovery was between 70 % and 130 %. We further evaluated this assay with some commercially obtained clinical samples. This presentation includes detailed results of this study. Citation Format: Neeraja Venkateswaran, William M. Nelson. A novel multiplex assay for detection and quantitation of fatty acid synthase (FASN) in serum or plasma samples [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr LB-248.
Nasal and lower airway level of nitric oxide in children with primary ciliary dyskinesia
Authors: B Karadag, A.j James, E Gültekin, N.m Wilson, A Bush
Journal: European Respiratory Journal (1999)

The aim of this study was to compare exhaled nitric oxide concentrations obtained during controlled slow exhalation, presently considered as the method of choice, with two sampling methods that are easily performed by children: blowing air into a balloon and tidal breathing through a mouthpiece. One hundred and one well controlled, stable allergic asthmatic children (median age 11.7 yrs) performed the following tasks in duplicate: 1) exhalation from total lung capacity through a mouthpiece against a resistor with a standardized flow rate of 20% of the subject9s vital capacity per second, using a biofeedback system; 2) a single deep exhalation into an NO-impermeable mylar balloon; and 3) tidal breathing through a low resistance mouthpiece over 2 min. NO was measured using a chemiluminescence analyser. Twenty-nine children (29%) were not able to perform a constant-flow exhalation of at least 3 s. All children performed the balloon and tidal breathing methods without difficulty. NO concentrations (means +/-SEM) were 5.3+/-0.2 parts per billion (ppb) at the end-expiratory plateau, 5.2+/-0.3 ppb in balloons (intraclass correlation coefficient (r(i)) = 0.73) and 8.0+/-0.4 ppb during tidal breathing (p&lt;0.001, r(i) = 0.53 compared to plateau values). Mean values of NO during tidal breathing increased significantly with time, suggesting increasing contamination with nasal air. It was concluded that, in asthmatic children, the end-expiratory plateau concentration of nitric oxide during exhalation at 20% of the vital capacity per second is similar to the values obtained with the balloon method, with satisfactory agreement, but differs from values obtained during tidal breathing. The balloon method is cheap, simple and offers the interesting possibility to study exhaled nitric oxide in young children independently of the presence of a nitric oxide analyser.
Letter to the Editor
Authors: T. O CHENG
Journal: Cardiovascular Research (1992)

Journal Article Letter to the Editor Get access TSUNG O CHENG TSUNG O CHENG George Washington University, Washington DC, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 26, Issue 4, April 1992, Page 431, https://doi.org/10.1093/cvr/26.4.431 Published: 01 April 1992
Cyanide evades some noses, overpowers others
Authors: E. R. Gonzalez
Journal: JAMA (1982)

In crimes such as the recent mass murder by use of adulterated Extra-Strength Tylenol capsules, the best form of detection is sometimes olfaction. A pathologist or other sleuth with the genetically acquired ability to smell cyanide can literally "sniff out" a death resulting from this quick-acting poison—at least as soon as the body is open and he gets a whiff of the gastric contents or tissues that contain the toxin. But approximately 40% to 60% of the populace is not so lucky. One pathologist in the Cook County, Ill, Medical Examiner's Office who was involved with the recent investigation of Tylenol poisonings told<i>JAMA</i>MEDICAL NEWS that he could not detect cyanide even if it were life threatening. "At a very high level, I might smell a slightly pungent odor, but nothing that I would necessarily notice," he remarked. The odor is classically described as resembling the smell of bitter
UNGUARDED RHETORIC.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Update: Interim Guidance for Prevention of Sexual Transmission of Zika Virus — United States, 2016
Authors: Alexandra M. Oster, Kate Russell, Jo Ellen Stryker, Allison Friedman, Rachel E. Kachur, Emily E. Petersen, Denise J. Jamieson, Amanda C. Cohn, John T. Brooks
Journal: MMWR Morbidity and Mortality Weekly Report (2016)
STUDIES ON THE ETIOLOGY OF SPONTANEOUS CONJUNCTIVAL FOLLICULOSIS OF RABBITS
Authors: Peter K. Olitsky, Jerome T. Syverton, Joseph R. Tyler
Journal: The Journal of Experimental Medicine (1934)

Spontaneous conjunctival folliculosis is widespread among various species of rabbits. It exists in two forms: Type I, in which the lesions are localized and the disease is relatively inactive, and Type II, in which the follicles are closely distributed over the entire surface of the conjunctivae and the affection is more active and characterized by extensive inflammatory reactions. One type can be converted into the other either by experimental methods or by natural processes. The disease can be transmitted from rabbit to rabbit by means of subconjunctival inoculation of suspensions of the affected tissues or by instillation of such material into the conjunctival sac, or even by mere contact of folliculosis animals with rabbits having smooth conjunctivae. It is plain that the disease is an infection. The causal agent of the infection is not filtrable through Seitz discs that retain Serratia marcescens nor through Berkefeld V candles that permit the passage of this organism. Furthermore, the lesions of the spontaneous or of the experimental disease do not exhibit the cytotropic effects or the inclusion bodies suggestive of the action of an ultramicroscopic virus. They are characterized, on the other hand, by a persistent and progressive chronicity and show certain resemblances to the granulomata. The evidence suggests that the spontaneous conjunctival folliculosis of rabbits is due to a microorganism—one having a low grade pathogenic action. In a paper shortly to be published, a bacterium capable of reproducing folliculosis in normal rabbits will be described.
Varicella Outbreak in a Women's Prison—Kentucky
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Renal carbuncle.
Authors: G T Watts
Journal: BMJ (1973)

Riot Control Agent SIR,-In your leading article (7 July, p. 5) it vws reported that an improvement on the riot control CS gas is on the way.It is code-named CR and, being of low toxicity but extremely irritant to skin, eyes, nose and throat, only very little would cause con- siderable pain and discomfort.In the article there was no expression of concern or disgust that oral LD 5 tests were done on animals to test the toxicity of the compound.If a dose of very low toxicity can cause such acute symptoms when applied to the skin and mucous membranes it seems quite possible that doses of high, lethal, toxicity, even when given by other routes, will cause severe pain and distress.Does medical ethics approve the use of animals in this way in testing substances which only our own folly have made necessary?-Iam, etc., J. D. WHITTALL Rye, Sussex Haemolytic-Uraemic Syndrome with Pericarditis SIR,-We were interested in the case re- ported by Drs.J. A. Utting and D. R. Shreeve (9 June, p. 591) of a patient with haemolytic-uraemic syndrome and pericarditis.Their statement that "no cases with prominent friction rubs due to the micro- angiopathy have previously been described" is not correct.In 1972 we reported1 a case of haemolytic-uraemic syndrome and nmicroan- giepathy in a woman with a hydatidiform mole who had a strong pericardial rub and who recovered with heparin therapy.This rub also was unrelated to uraemia.-Weare, etc.,
Health in Schools
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prevalence of Overweight Among Adolescents—United States, 1988-1991
Journal: JAMA (1994)

Among adults, overweight is associated with increased risk for death, coronary heart disease, diabetes mellitus, gallbladder disease, joint disease, and certain cancers (1), and overweight during adolescence is associated with increased risk for overweight as an adult (2). CDC's third National Health and Nutrition Examination Survey (NHANES III) provides data to monitor changes in the dietary, nutritional, and health status of the U.S. population (3) and to track progress toward achieving the year 2000 national health objectives, including those related to prevalence of overweight (4). This report presents findings from NHANES III, Phase 1 (1988-91), on the prevalence of overweight among U.S. adolescents (ages 12-19 years).
Bone marrow curettage in myelodysplastic disorders. A stimulus for regeneration in disturbed hematopoiesis
Authors: Y. Matzner
Journal: JAMA (1981)

Bilateral bone marrow curettage of the iliac crest was performed in eight patients with marked anemia resulting from various myelodysplastic syndromes. The procedure was performed with the idea that an element of faulty hematopoietic microenvironment existed and that regeneration of normal marrow might occur in areas distant from the site of curettage. Four of the eight patients failed to respond to this procedure and no long-term response was obtained. One of the "failed" patients had a delayed response 18 months after the curettage was performed. In four patients, the procedure proved to be successful and adequate hemoglobin levels were achieved (10 to 14 g/dL) with reduction of the blood transfusion requirement. The diseases of two of these patients are still in remission 26 to 96 months after the procedure was performed. The procedure is recommended for patients with anemia refractory to conventional therapy and in whom a faulty hematopoietic microenvironment may be present. (<i>JAMA</i>1981;246:1926-1928)
'Essential components now in place' for clinical testing of cancer vaccine strategies, experts say
Authors: A. A. Skolnick
Journal: JAMA (1995)

ACCORDING to experts at the Cancer Research Institute's "Cancer Vaccines 1994" symposium, held in New York, NY, medicine is entering a "new era of immunologically based treatments for cancer." The conference was the first in a planned series of biennial meetings on cancer vaccines. "We anticipate that this symposium will become the major forum for reporting on vaccine research and will help foster development of the first effective therapeutic cancer vaccine," said Jill O'Donnell-Tormey, PhD, executive director of the New York—based Cancer Research Institute, a nonprofit organization that supports research in cancer immunology. The institute is establishing a cancer vaccine trial registry to serve as a centralized source of information for the scientific and clinical communities about all ongoing vaccine trials. The registry will track progress in the field and maintain status reports on the various trials. Now that researchers are defining the structure of tumor peptides that are recognized
Fiduciary Responsibility
Authors: M. J. Wizenberg
Journal: JAMA (1978)

<h3>To the Editor.—</h3> "We Physicians Are Fiduciary Failures" (239:1629, 1978) points up a most valuable concern, but fails to take into account many other equally important aspects of the problem. Indeed, if we are to discharge our fiduciary relationship to the patient honorably, we should consider only that individual's physical, mental, and financial well-being rather than that of some third party. Obviously the latter is inappropriate, but if we are going to play a perfectly open game with the patient in terms of cost, should we not also explain to the patient the cost-effectiveness ratio of each given test or procedure, the role of the sequence in which these are done, including delays that may be introduced as a result of sequence (eg, a small-bowel contrast study can be done almost immediately after intravenous pyelography but not vice versa)? Furthermore, the patients would have to assume some liability for consequences
Postscription
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Electrothermic Methods (Desiccation and Coagulation) in the Treatment of Neoplastic Diseases: Designed as a Practical Handbook of Surgical Electrotherapy for the Use of Practitioners and Students.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Great Painters and Their Works as Seen by a Doctor. I: Rembrandt. A Series of Monographs.
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
On Appetite and Its Loss
Authors: Aminah Jatoi, Shaji Kumar, Jeff A. Sloan, Phuong L. Nguyen
Journal: Journal of Clinical Oncology (2000)

Article Tools THE ART OF ONCOLOGY: WHEN THE TUMOR IS NOT THE TARGET Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2000.18.15.2930 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 10920143 On Appetite and Its Loss Aminah JatoixAminah JatoiSearch for articles by this author , Shaji KumarxShaji KumarSearch for articles by this author , Jeff A. SloanxJeff A. SloanSearch for articles by this author , Phuong L. NguyenxPhuong L. NguyenSearch for articles by this author Show More From the Division of Medical Oncology and Department of BiostatisticsMayo Clinic, Rochester; and Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN. https://doi.org/10.1200/JCO.2000.18.15.2930 First Page Full Text PDF Figures and Tables © 2000 by American Society of Clinical Oncology