tbuckley/cabot-search huggingface dataset:
Study of Cytotoxic Chemotherapy as an Adjuvant to Surgery in Carcinoma of the Bronchus
Journal: BMJ (1971)

This report gives the findings after two years of a study of long-term oral cytotoxic chemotherapy with busulphan or cyclophoshamide in carcinoma of the bronchus compared with two placebos, identical in appearance to the drug-containing tablets. A total of 753 patients who had had a total resection of the tumour, who had no detectable extrathoracic metastasis, and who were able to attend chest clinics monthly were admitted to the study from January 1965 to January 1968. Twenty-seven patients were excluded from all the analyses. The 217 patients admitted up to December 1965 form the “early” intake, the remaining 509 the “late” intake. There were no significant differences between the series in either intake period in a number of pretreatment factors studied. At 24 months 46% of the busulphan, 44% of the cyclophosphamide, and 49% of the placebo series were alive in the early intake, as were 49%, 50%, and 50% respectively in the late intake. There were no important differences between the series in survival related to pretreatment condition, cause of death, time of detection of metastases, and condition of the survivors at 24 months. Maintenance chemotherapy was interrupted to a greater extent in the busulphan than in the cyclophosphamide series and least in the placebo series. In both intakes clinical toxicity was more frequent in the cyclophosphamide series and similar in frequency in the busulphan and placebo series. Haematological toxicity was particularly frequent and severe in the busulphan series, especially in the early intake, platelet depression being the predominant manifestation. It is concluded that there is no evidence that either of the two cytotoxic drugs in the dosage prescribed improved survival for the two-year period of observation, though a final evaluation of the adjuvant chemotherapy as studied in this investigation will have to await the results at five years.
Correction
Journal: BMJ (1962)

Any Questions?We publish below a selection of those questions and answers which seem of general interest.It is regretted that it is not possible to supply answers to all questions sii)bnitted.Weight-reducing Peptic Ulcer Diet Q.-What principles should govern the dieting of ani overweight woman with a gastric ulcer so that weight is reduced ?A.-This is a difficult problem.Most patients on a gastric diet who have to feed every two or three hours will increase in weight, as the usual procedure is for them to eat earbohydrate-containing foods between meals.It is possible to give a 1,000-1,200 calorie diet and to fulfil the underlying principle of frequent feeding.This involves, however, the use of food which the patient cannot often carry.On the whole it is probably better to separate the treatment of the problems in time. Acetone FumesQ.-Is the inhalation of acetone fumes harmful, anid in what way ?A.-Acetone is a mild narcotic and an irritant affecting mucous membranes.In industry its narcotic effect is rarely powerful enough to produce unconsciousness, but Ethel Browning reports' that repeated exposure may cause drowsi- ness.Acute poisonirng is a very rare event: symptoms include nausea, vomiting, fainting, and collapse, with no apparent permanent injury after recovery.The maximuim allowable concentration is 1,000 parts per million.
CORRECTION
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CLIN-PATHOLOGY
Authors: D. Alexandru, R. Satyadev, W. So, S. H. Lee, Y. S. Lee, Y.-K. Hong, C. S. Kang, S. D. Rodgers, B. J. Marascalchi, R. G. Strom, H. Riina, U. Samadani, A. Frempong-Boadu, R. Babu, C. Sen, D. Zagzag, M. D. Anderson, T. W. Abel, P. L. Moots, Y. Odia, B. A. Orr, C. G. Eberhart, F. Rodriguez, R. T. Sweis, J. Lavingia, J. Connelly, E. Cochran, M. van den Bent, C. Hartmann, M. Preusser, T. Strobel, H. J. Dubbink, J. M. Kros, A. von Deimling, B. Boisselier, M. Sanson, K. C. Halling, K. L. Diefes, K. Aldape, C. Giannini, F. J. Rodriguez, A. H. Ligon, I. Horkayne-Szakaly, E. J. Rushing, K. L. Ligon, N. Vena, D. I. Garcia, J. Douglas Cameron, C. G. Eberhart, A. Raghunathan, K. Wani, T. S. Armstrong, E. Vera-Bolanos, M. Fouladi, A. Gajjar, S. Goldman, N. L. Lehman, P. Metellus, T. Mikkelsen, M. J. T. Necesito-Reyes, A. Omuro, R. J. Packer, S. Partap, I. F. Pollack, M. D. Prados, H. Ian Robbins, R. Soffietti, J. Wu, M. R. Gilbert, K. D. Aldape, M. Prosniak, L. A. Harshyne, D. W. Andrews, D. Craig Hooper, N. Kagawa, N. Hosen, N. Kijima, R. Hirayama, Y. Chiba, F. Yamamoto, M. Kinoshita, N. Hashimoto, Y. Fujimoto, T. Yoshimine, J. Hu, M. Nuno, C. Patil, J. Rudnick, S. Phuphanich, S. Bannykh, R. Chu, J. Yu, K. Black, J. Choi, D. Kim, K. W. Shim, S. H. Kim, H. Kanno, H. Nishihara, S. Tanaka, H. Nishihara, T. Yanagi, H. Kanno, S. Tanaka, P. Buczkowicz, D.-A. Khuong-Quang, P. Rakopoulos, E. Bouffet, A. Morrison, U. Bartels, S. M. Pfister, N. Jabado, C. Hawkins, B. D. Weinberg, K. L. Newell, P. Kumar, F. Wang, S. Venneti, M. Madden, T. Coyne, J. Phillips, D. Gorovets, J. Huse, J. Kofler, C. Lu, T. Tihan, L. Sullivan, M. Santi, A. Judkins, C. Thompson, A. Perry, J. B. Iorgulescu, I. Laufer, M. Hameed, E. Lis, P. Boland, R. Komotar, M. Bilsky, A. C. Amato-Watkins, J. Neal, A. D. Rees, J. S. Davies, C. Hayhurst, C. Lu-Emerson, M. Snuderl, C. Davidson, N. D. Kirkpatrick, Y. Huang, D. G. Duda, M. Ancukiewicz, A. Stemmer-Rachamimov, T. T. Batchelor, R. K. Jain, B. Ellezam, B. J. Theeler, Z. S. Sadighi, V. Mehta, M.-D. T. Tran, A. M. Adesina, V. K. Puduvalli, J. M. Bruner
Journal: Neuro-Oncology (2012)
lododerma From Wound Irrigation With Povidone-lodine
Authors: Marvin E. Bishop
Journal: JAMA (1978)

IODODERMA is a protean group of skin lesions that includes urticarial lesions, acneiform papules and pustules, vesicles, bullae, vegetating lesions, nodules, and tumors. It is usually induced by the ingestion of iodides such as are found in cough medicines and expectorants. This case report is unique in that pustular iododerma followed wound irrigation with 10% povidone-iodine. <h3>Report of a Case</h3> A 57-year-old man complained of a generalized pustular eruption. He had bilateral wound abscesses in the groin from a six-month-old aortal bifemoral bypass. The wounds had been incised, drained, debrided, and irrigated with 10% povidone-iodine at the rate of 100 ml/hr via intracatheters for 24 hours. The patient also began receiving oxacillin and chloramphenicol one day before the debridement. Twenty-four hours after debridement, numerous 2- to 4-mm pustules on an erythematous base appeared on the arms, face, and thighs. The lesions were especially numerous on the eyelids and beneath a
MicroRNA-Containing T-Regulatory-Cell-Derived Exosomes Suppress Pathogenic T Helper 1 Cells
Authors: Isobel S. Okoye, Stephanie M. Coomes, Victoria S. Pelly, Stephanie Czieso, Venizelos Papayannopoulos, Tanya Tolmachova, Miguel C. Seabra, Mark S. Wilson
Journal: Immunity (2014)

(Immunity 41, 89–103, July 17, 2014) In the version of this paper originally published online, the accession number for the microarray data presented in the paper was omitted. This omission has now been corrected, and the journal regrets the error. MicroRNA-Containing T-Regulatory-Cell-Derived Exosomes Suppress Pathogenic T Helper 1 CellsOkoye et al.ImmunityJuly 17, 2014In BriefThe mechanisms through which T regulatory (Treg) cells prevent inflammation are not fully understood. Okoye et al. show that Treg cells release exosomes that transfer miRNAs to target T helper cells and suppress T-cell-mediated disease. Full-Text PDF Open Access
Foreign Medicine
Authors: Mohsen Eledrisi
Journal: Annals of Internal Medicine (2004)

Letters7 December 2004Foreign MedicineMohsen Eledrisi, MDMohsen Eledrisi, MDFrom King Abdulaziz National Guard Medical City, Alahsa, Saudi Arabia 31982.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-141-11-200412070-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In his essay (1), Dr. Verghese elegantly addressed the issue of foreign (or international) medical graduates (FMGs) and the hardship and hurdles they face to pursue graduate medical education in the United States. There is another aspect of this subject. Foreign medical graduates account for 27% of the 96 937 residents and fellows and a quarter of the 853 187 physicians in the United States (2). About 40% of primary care programs in the United States are already dependent on FMGs, and two thirds of the total number of FMGs serve in hospitals that provide a disproportionate share of ...References1. Verghese A. Resident redux. Ann Intern Med. 2004;140:1034-6. [PMID: 15197021] LinkGoogle Scholar2. Physician Characteristics and Distribution in the US, 2004-2005. Chicago: American Medical Association Pr; 2003. Google Scholar3. Whitcomb ME, Miller RS. Participation of international medical graduates in graduate medical education and hospital care for the poor. JAMA. 1995;274:696-9. [PMID: 7650821] CrossrefMedlineGoogle Scholar4. Ozuah PO, Curtis J, Dinkevich E. Physical examination skills of US and international medical graduates [Letter]. JAMA. 2001;286:1021. [PMID: 11559281] CrossrefMedlineGoogle Scholar5. Whelan GP, Gary NE, Kostis J, Boulet JR, Hallock JA. The changing pool of international medical graduates seeking certification training in US graduate medical education programs. JAMA. 2002;288:1079-84. [PMID: 12204075] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From King Abdulaziz National Guard Medical City, Alahsa, Saudi Arabia 31982. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoResident Redux Abraham Verghese Metrics 7 December 2004Volume 141, Issue 11Page: 890-891KeywordsGraduate medical educationHealth economics ePublished: 7 December 2004 Issue Published: 7 December 2004 CopyrightCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Archives of Environmental Health, Chicago
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Editorial: Single daily dose of antidepressants
Authors: F. J. Ayd
Journal: JAMA (1974)

In recent years, there has been a spate of articles on the failure of patients to take medicine as directed and the impact of this on therapeutic outcome. Many of these studies have been reviewed by Stewart and Cluff<sup>1</sup>and by Blackwell.<sup>2</sup>They disclose a disturbing rate of noncompliance ranging from 20% to 82%. In one study, individuals judged to be very unreliable were excluded.<sup>3</sup>Even with this restriction, 31% of the "reliable" patients took less than 70% of their medication. The magnitude of the patient noncompliance problem is even greater than the data indicate, because most of the methods for measuring compliance are limited to finding the extremes only—those who comply fully, or those who comply minimally or not at all. The majority of patients in compliance studies were taking divided doses of a single drug. A substantial number of patients today, however, are simultaneously taking
Reference Committees 1982 Annual Meeting
Journal: JAMA (1982)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The MEKK1-JNK pathway plays a protective role in pressure overload but does not mediate cardiac hypertrophy
Authors: Junichi Sadoshima, Olivier Montagne, Qian Wang, Guiping Yang, Jill Warden, Jing Liu, Gen Takagi, Vijaya Karoor, Chull Hong, Gary L. Johnson, Dorothy E. Vatner, Stephen F. Vatner
Journal: Journal of Clinical Investigation (2002)

Mitogen-activated protein kinase kinase kinase (MEKK1) mediates activation of c-Jun NH2-terminal kinase (JNK). Although previous studies using cultured cardiac myocytes have suggested that the MEKK1-JNK pathway plays a key role in hypertrophy and apoptosis, its effects in cardiac hypertrophy and apoptosis are not fully understood in adult animals in vivo. We examined the role of the MEKK1-JNK pathway in pressure-overloaded hearts by using mice deficient in MEKK1. We found that transverse aortic banding significantly increased JNK activity in Mekk1+/+ but not Mekk1–/– mice, indicating that MEKK1 mediates JNK activation by pressure overload. Nevertheless, pressure overload caused significant levels of cardiac hypertrophy and expression of atrial natriuretic factor in Mekk1–/– animals, which showed higher mortality and lung/body weight ratio than were seen in controls. Fourteen days after banding, Mekk1–/– hearts were dilated, and their left ventricular ejection fraction was low. Pressure overload caused elevated levels of apoptosis and inflammatory lesions in these mice and produced a smaller increase in TGF-β and TNF-α expression than occurred in wild-type controls. Thus, MEKK1 appears to be required for pressure overload–induced JNK activation and cytokine upregulation but to be dispensable for pressure overload–induced cardiac hypertrophy. MEKK1 also prevents apoptosis and inflammation, thereby protecting against heart failure and sudden death following cardiac pressure overload.
A Modified Method of Radioisotopic Placental Localization
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Temporal Arteritis—Dysphagia and a Normal ESR
Authors: Peter Watson
Journal: JAMA (1984)

<h3>To the Editor.—</h3> Temporal arteritis (TA) may be seen in unusual ways.<sup>1,2</sup>This patient's case is reported because of its singular nature, particularly the prominent dysphagia. Earlier treatment might have prevented the subsequent tragic visual loss. <h3>Report of a Case.—</h3> A 66-year-old woman sustained blindness in the left eye four days before to admission. On admission, she had the funduscopic findings of central retinal artery occlusion on the left. She had not suffered headache, myalgia, weight loss, fever, malaise, or jaw claudication. Her only other complaint was discomfort on swallowing of two weeks' duration, to such a degree that she took only tepid fluids. The superficial temporal artery was nontender and weakly palpable bilaterally. Her ESR (Westergren) was 18 and 4 mm/hr on separate occasions, measured within an hour of the blood sample being taken. She was not anemic. On the second hospital day she complained of transient obscuration
ALBERT ABRAMS
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
WEIGHT CONTROL
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Granuloma Inguinale
Authors: P. N. Rangiah
Journal: JAMA (1962)

<h3>To the Editor:—</h3> InThe Journal(<i>JAMA</i><b>176</b>:530 [May 13] 1961) a report entitled "Granuloma Inguinale with Hematogenous Dissemination to the Spine," under the authorship of Dr. Bernard M. Kalstone et al., has appeared. I find that, on page 532, under<i>Comment</i>, a reference has been made to Dr. R. V. Rajam, myself, and Dr. Anguli. The words are: "Also, only a single case of involvement of the lumbar vertebra by hematogenous spread has been reported, and that case is suspected as being tuberculosis rather than granuloma inguinale." Going through in detail a case report entitled "Systemic Donovanosis" (<i>Brit J Vener Dis</i><b>30</b>:75, 1954) I find: "There was marked oedema both of feet and legs. The right hip was kept flexed and any attempt at extension of the limb caused great pain. On the anteromedial aspect of the middle of the right leg a localised, painful, and tender
The international metric system and medicine
Authors: S. M. Vawter
Journal: JAMA (1971)

The United States is one of only nine nations in the world which use a nonmetric system of units for weights and measures. One hundred thirty-three nations, including the USSR, China, Japan, France, and Germany use a metric system. Additionally, 16 nations, including Australia, Canada, and the United Kingdom, are in the process of adopting a metric system. In the United States itself, utilization of the metric system has been steadily increasing. Since 1878, when the House of Delegates of the American Medical Association recommended the use of the metric system, American medicine has established an enviable record regarding the utilization of metric notations in medical practice and research. Today's level of accomplishment should serve to encourage other segments of US society which also must inevitably adopt a metric system of measurement. Public Law 90-472 authorized the secretary of commerce to study the advantages and disadvantages of increased use of