tbuckley/cabot-search huggingface dataset:
Human Neuroblastoma Cell Lines as Models for the In Vitro Study of Neoplastic and Neuronal Cell Differentiation
Authors: Elliot Abemayor, Neil Sidell
Journal: Environmental Health Perspectives (1989)

Neuroblastoma is a childhood solid tumor composed of primitive cells derived from precursors of the autonomic nervous system. This neoplasm has the highest rate of spontaneous regression of all cancer types and has been noted to undergo spontaneous and chemically induced differentiation into elements resembling mature nervous tissue. As such, neuroblastoma has been a prime model system for the study of neuronal differentiation and the process of cancer cell maturation. In this paper we review those agents that have been described to induce the differentiation of neuroblastoma, with an emphasis on the effects and possible mechanisms of action of a group of related compounds, the retinoids. With this model system and the availability of subclones that are both responsive and resistant to chemically induced differentiation, fundamental questions regarding the mechanisms and processes underlying cell maturation have become more amenable to in vitro study.
Travel
Authors: J T Lynn
Journal: Annals of Internal Medicine (1994)

On Being a Doctor1 August 1994TravelJohn T. Lynn III, MDJohn T. Lynn III, MDColorado Springs, CO 80903Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-121-3-199408010-00011 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail As I pulled the morning's last chart from its wooden cradle, I delighted in the prospect of seeing my patient Carl Swensen again. I was selfish: While hearing about Carl's health, I always learned something about life.Our eyes met, and Carl nodded eagerly. Tangled, charcoal eyebrows brushed his thick, oil-smudged lenses. Bony shoulders angled forward, and slender fingers, pulled to the side by years of rheumatoid arthritis, curled around the corners of the examination table. Long legs hung from the wide silver buckle, engraved with the word Colorado, that indented his thin waist. Soft leather shoes sympathetically covered his ... Author, Article, and Disclosure InformationAffiliations: Colorado Springs, CO 80903Corresponding Author: John T. Lynn, MD, Arthritis Affiliates, PC, 801 North Cascade Avenue, Suite 22, Colorado Springs, CO, 80903. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1994Volume 121, Issue 3Page: 231KeywordsAnestheticsChartsCoffeeEngineersFoodHearingKneesRheumatoid arthritisShoulders Issue Published: 1 August 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
AMA Insights
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
HOSPITALS REGISTERED BY THE AMERICAN MEDICAL ASSOCIATION
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Letter: Effects of exertion on hormone secretion.
Authors: H Aldercreutz, A Dessypris
Journal: BMJ (1974)

natal bed rest may actually have a deleterious effect upon fetal growth and well-being and that until this basic problem is settled it is not possible to say whether the better results obtained by Dr. Varma and Professor Curzen in their decompressed patients are more likely to have been effected by the dcompression itself or by the lesser amount of enforced bed rest to which they were subjected.-Iam, etc.,
Ueber das Kongenitalitätsproblem der Syphilis.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reference Committees 1980 Interim Meeting
Journal: JAMA (1980)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Introduzione alla biometria
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical Lectures on Stricture of the Urethra
Authors: B. Hill
Journal: BMJ (1879)

IN describing the mode of operating by internal urethrotomy, I need not take up your time with showing you the numerous armament of in- -struments, each of which is intended to carry out the special fancy of its contriver for cutting through the stricture.They may all be collected into two classes: those which cut from behind towards the
Ten centre trial of artificial surfactant (artificial lung expanding compound) in very premature babies. Ten Centre Study Group.
Authors: D Lloyd, P Duffty, G Durbin, I Morgan, C Morley, A Greenough, M South, Rosie Maternity, R Hume, T Marshall, T Turner, A Sutton, A Glasgow Queen Mother's Hospital, J Greenough, H Poole, King Gamsu, R Cooke, J Rennie, E Hey, Newcastle Princess, Mary Maternity, S Thurlbeck, N Mcintosh, St George', P Dear, D Wheeler, Mr Miller, A Bangham
Journal: BMJ (1987)

A protein free artificial surfactant (artificial lung expanding compound; ALEC) composed of dipalmitoylphosphatidylcholine and phosphatidylglycerol was assessed for its effect on the main complications of prematurity in a prospective two stage randomised trial of 328 unselected babies delivered at between 25 and 29 weeks of gestation. Babies were randomised to receive approximately 100 mg artificial surfactant suspension or 1 ml saline. This was given at birth into the pharynx with up to three more endotracheal doses if the baby was intubated during the first day. Treatment with artificial surfactant reduced the neonatal mortality from 27% to 14%, the incidence of parenchymal brain haemorrhages from 24% to 16%, and the severity of the respiratory distress syndrome. In the first 10 days babies treated with artificial surfactant who survived averaged 19 hours less in greater than 30% oxygen, 20 hours less ventilation, and 17 hours less supplemental oxygen. Artificial surfactant had no effect on the incidence of pneumothoraces, pulmonary interstitial emphysema, patent ductus arteriosus, or postnatal infections and no serious side effects. Artificial surfactant (ALEC) given to very premature babies at birth significantly reduces their mortality and the respiratory support needed and should prove a valuable addition to treatment.
407P Pembrolizumab Expanded Access Program (EAP) in Taiwan for patients with progressive advanced melanoma after prior ipilimumab treatment
Authors: C-K. Yang, J-H. Liu, C-C. Lin, T-C. Liu, P-T. Cheng, C-Y. Lin, H-T. Hu, C-R. Cao, W-T. Huang, L-P. Chen, W-C. Chang
Journal: Annals of Oncology (2016)
SportsMedUpdate
Authors: Martin P Schwellnus
Journal: British Journal of Sports Medicine (2010)

1. Song C-Y, 2. Lin Y-F, 3. Wei T-C, 4. et al . Surplus value of hip adduction in leg-press exercise in patients with patellofemoral pain syndrome: a randomised controlled trial Phys Ther 2009;89:409–18. [OpenUrl][1][Abstract/FREE Full Text][2] ### Background Patellofemoral pain syndrome (PFPS) is a common chronic knee injury that is frequently treated by rehabilitation of the vastus medialis oblique (VMO) muscle – however, it has been suggested that additional hip adduction training may result in improved clinical outcomes of this condition. ### Research question/s Does the addition of hip adduction exercises to VMO exercises further reduce pain and improve function in patients with PFPS? ### Methodology Subjects: 79 out of 89 recruited subjects with PFPS (clinical diagnosis) completed the study (male=20). Experimental procedure: All the subjects were initially assessed (pain (100 mm Visual Analogue Scale), function (Lysholm scale scores), and VMO morphology (cross-sectional area – CSA and volume using ultrasound)) and then randomly assigned to one of three treatment groups for 8 weeks (3/week): no exercise rehabilitation (CON=25); VMO exercise only (leg-press) (VMO=27); and VMO exercise combined with hip adduction (VMO+HA=27). Measurements were repeated after … [1]: {openurl}?query=rft.jtitle%253DPhys%2BTher%26rft_id%253Dinfo%253Adoi%252F10.2522%252Fptj.20080195%26rft_id%253Dinfo%253Apmid%252F19299508%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/ijlink?linkType=ABST&journalCode=ptjournal&resid=89/5/409&atom=%2Fbjsports%2F44%2F9%2F691.atom
A Textbook of Pathology
Authors: William B. Bean
Journal: JAMA (1962)

With the world of medicine advancing with bewildering rapidity in many directions it is refreshing to see a standard textbook brought up to date so competently with a vigorous, continuing, and generally successful effort to present pathology to the undergraduate student, house officer, or practicing physician rather than just for the pathologist, talking to the pathologist. Though medical knowledge increases at an exponential rate, the mind of the physician still is pretty much the 2-dimensional machine it has always been. The great effort to keep up with the expanding complexity of the medical world has increased in difficulty. Data accumulate so much faster than any solution for the problems can be found. One refreshing exception among textbooks is Boyd's treatise on Pathology. It manages to encompass a vast body of material, surprisingly up-to-date, integrated very wisely with clinical clues without aiming to be a textbook of medicine. Its main emphasis,
Infectious mononucleosis in acute lymphocytic leukemia
Authors: J. Blom
Journal: JAMA (1965)

An 18-year-old high-school student was found to have lymphoblastic leukemia at the age of 16 years. Remission was obtained with weekly doses of 2 mg/sq m of body surface of vincristine sulfate and daily doses of 40 mg/ sq m of prednisone. Maintenance treatment with intramuscular administration of methotrexate, 30 mg/sq m twice weekly, was initiated, after which febrile episodes developed on three occasions. It is believed that they were related to the drug. After the leukemia had been in remission for about one year, infectious mononucleosis developed and the patient had marked elevation of heterophil antibody titer without adsorption by guineapig kidney. Only one similar case was found in the literature. One case of lymphoblastic leukemia was preceded by infectious mononucleosis. At the time of this report, the patient's leukemia has been in remission for over two years.
Smoking-Attributable Mortality, Years of Potential Life Lost, and Productivity Losses—United States, 2000-2004
Journal: JAMA (2009)

Cigarette smoking and exposure to tobacco smoke are associated with premature death from chronic diseases, economic losses to society, and a substantial burden on the United States health-care system. Smoking is the primary causal factor for at least 30% of all cancer deaths, for nearly 80% of deaths from chronic obstructive pulmonary disease, and for early cardiovascular disease and deaths. In 2005, to assess the economic and public health burden from smoking, CDC published results of an analysis of smoking-attributable mortality (SAM), years of potential life lost (YPLL), and productivity losses in the United States from smoking during 1997-2001. The analysis was based on data from CDC's Smoking-Attributable Mortality, Morbidity, and Economic Costs (SAMMEC) system, which estimates SAM, YPLL, and productivity losses based on data from the National Health Interview Survey and death certificate data from the National Center for Health Statistics. This report presents an update of that analysis for 2000-2004, the most recent years for which source data are available. The updated analysis indicated that, during 2000-2004, cigarette smoking and exposure to tobacco smoke resulted in at least 443,000 premature deaths, approximately 5.1 million YPLL, and $96.8 billion in productivity losses annually in the United States. Comprehensive, national tobacco-control recommendations have been provided to the public health community with the goal of reducing smoking so substantially that it is no longer a significant public health problem in the United States.
Congenital malformations following chickenpox, measles, mumps, and hepatitis. Results of a cohort study
Authors: M. Siegel
Journal: JAMA (1973)

The incidence of major malformations following maternal chickenpox, mumps, measles, and viral hepatitis was observed in a controlled, cohort study of offspring followed up until five years of age. Major congenital defects occurred in each viral group, but the malformations were equal in frequency and often similar in type to those observed among comparable controls for the respective viral groups. Consequently, the malformations that occurred could not be attributed directly to the associated diseases under study.
Radiation-related health risks. Future directions for research
Authors: G. R. Howe
Journal: JAMA (1995)

This issue ofTHE JOURNALincludes articles on the therapeutic uses of ionizing radiation and the long-term adverse health consequences of radiation exposure. The balancing of benefit and risk is critical both in assessing the utility of medical applications of radiation and nonmedical applications, such as nuclear power generation, where the Chernobyl incident demonstrated the potentially disastrous consequences of unsafe operation.<sup>1</sup>In many medical applications, such as radiotherapy for treating selected patients with cervical cancer as reported herein by Rotman et al,<sup>2</sup>direct benefits may often outweigh any long-term risk. However, some medical uses, such as mammographic screening, require a careful and quantitative analysis of the benefits and risks involved. Thus, a critical need exists to determine as precisely as possible the risks of subsequent adverse health outcomes following exposure to ionizing radiation. See also pp 387, 402, and 425. To date, the majority of data on such
Studies of Negative Ions by Collision-Induced Decomposition and Hydrogen-Deuterium Exchange Techniques
Authors: Donald F. Hunt, Satinder K. Sethi, Jeffrey Shabanowitz
Journal: Environmental Health Perspectives (1980)

Development of two new techniques for studying the gas phase chemistry of negative ions is reported. Collision induced dissociation (CID) of (M-1)- ions has been accomplished in a newly constructed triple stage quadrupole mass spectrometer. This instrument was assembled by adding two additional Finnigan quadrupole mass filters to a Finnigan Model 3200 CI mass spectrometer. Generation of (M-1)- ions is accomplished by allowing OH- and sample to react under CI conditions in the ion source. The first quadrupole mass filter, Q1, is then employed to selectively pass the (M-1)- ion into a second quadrupole filter containing argon or neon at 10(-3) torr. On collision with the inert gas the (M-1)- ions dissociate into fragments which are then mass analyzed in the third quadrupole filter, CID spectra of (M-1)- ions from twelve carbonyl compounds are presented in this paper. Ion molecule isotope exchange reactions in the CI ion source can be used to count the number of hydrogen atoms in many different chemical environments. Collisions between sample (M-1)- ions and deuterium-labeled reagent gases (ND3, D2O, EtOD) facilitate incorporation of deuterium into the negative ion if the basicities of the sample and reagent anions are similar. Thus it is possible to selectively incorporate deuterium into many organic samples by controlling the exothermicity of the acid base, ion-molecule chemistry.
Amplified Stethoscope for the Hearing-Impaired Physician
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fatal and Severe Hepatitis Associated With Rifampin and Pyrazinamide for the Treatment of Latent Tuberculosis Infection—New York and Georgia, 2000
Journal: JAMA (2001)

One of the recommended treatments for latent tuberculosis infection (LTBI) is a 9-month regimen of isoniazid (INH); a 2-month regimen of rifampin (RIF) and pyrazinamide (PZA) is an alternative in some instances. In September 2000, a man in New York died of hepatitis after 5 weeks of RIF-PZA, and in December, a woman in Georgia was admitted to a hospital because of hepatitis after 7 weeks of this regimen. This report summarizes the findings of the investigations of these incidents, which underscore the need for clinical monitoring for adverse effects in all patients receiving treatment for LTBI.