tbuckley/cabot-search huggingface dataset:
Great expectations
Authors: Howard A. Rockman
Journal: Journal of Clinical Investigation (2012)

On the occasion of the 200th anniversary of Charles Dickens's birth, I am struck by his creative genius and by the parallel between the intellectual development of his protagonists and the evolution of peer review. Like many of his novels and serial writings, the story of the history of peer review is a bildungsroman, one that has followed a process of growing up, sought answers through a journey marked by achievement and disappointment, and ultimately matured to be accepted by a community.
<i>Circulation: Cardiovascular Quality and Outcomes</i> Editors' Picks
Journal: Circulation (2012)

The following articles are being highlighted as part of Circulation's Topic Review series. This series summarizes the most important manuscripts, as selected by the editors, published in Circulation and the Circulation subspecialty journals. The studies included in this article represent the Editors' Picks for each Circulation: Cardiovascular Quality and Outcomes' issue published in 2011.
Population based randomised controlled trial on impact of screening on mortality from abdominal aortic aneurysm
Journal: BMJ (2005)

infarction with subsequent disability far more important than a short admission for acute coronary syndrome with rapid return to previous function.The answers to the other two questions are also negative.Hospital admissions occurred far more frequently than the two more important events (table ).Biological rationale fails to support a presumption that the invasive strategy will have similar effects on all three end points.Indeed, the investigators explicitly state that they expect an increase in short term deaths with surgery, while achieving benefits in terms of decreased angina and associated hospital admissions.The trend toward increased deaths, with a large reduction in admissions, with the invasive strategy provides support for this hypothesis.The composite end point thus fails all three criteria and provides little useful information for clinical decision making.
In This Issue
Journal: Journal of Clinical Investigation (2008)

KLF6-SV1 helps prostate cancer spread its wingsMetastatic prostate cancer (PCa) is the second most common cause of death from cancer for men.Defining the molecular mechanisms by which localized PCa progresses to metastatic PCa and the markers of this transition is important for developing strategies to identify individuals at risk of metastatic disease.Kruppel-like factor 6 (KLF6) is a tumor suppressor gene, but Narla, DiFeo, and colleagues have now shown that the KLF6 splice variant KLF6-SV1 is expressed at higher levels in prostate tissue from individuals with metastatic PCa than in prostate tissue from individuals with localized PCa (pages 2711-2721).Further analysis indicated that increased expression of KLF6-SV1 in men with localized PCa predicted decreased survival and more rapid disease recurrence.Consistent with increased levels of KLF6-SV1 having a biological role in metastasis, a PCa cell line overexpressing KLF6-SV1 metastasized more rapidly and more often than the parent PCa cell line when assessed in a mouse model of metastatic PCa.Conversely, siRNA knockdown of KLF6-SV1 expression in established tumors in a mouse model of PCa reduced tumor growth.These data led the authors to suggest that KLF6-SV1 might provide a therapeutic target for PCa as well as being a good indicator of whether a localized PCa tumor will progress to metastatic disease.
GRATUITOUS VACCINATIONS BY BOARDS OF HEALTH.
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
John Brocklehurst
Authors: N. Stafford
Journal: BMJ (2013)

The granulocyte-macrophage CSF (GM-CSF) gene is known to be controlled at a variety of levels in different cell types. We showed previously that GM-CSF production by lectin or phorbol ester (12-O-tetradecanoyl-phorbol-13-acetate (TPA]-treated T cells was unaffected by cyclosporin A whereas IL-2 and IL-3 expression were. Cyclosporin A is thought to inhibit transcription that suggests that IL-2 and IL-3 are regulated primarily at the transcriptional level while GM-CSF is not. The lack of coordinate gene expression is of particular interest because all three mRNA share the presence of adenosine uridine-rich sequences in the 39 untranslated region and these sequences are believed to act by modulating mRNA stability. We measured the level of GM-CSF mRNA in untreated cells and found it to be extremely low. GM-CSF mRNA levels increased approximately 60-fold within 6 h of TPA-treatment. Nuclear run-on transcription analysis of the same cells showed readily detectable GM-CSF transcription in unstimulated cells that increased less than twofold after TPA treatment. However, IL-2 transcription was insignificant before TPA addition. Actinomycin D chase experiments showed that GM-CSF transcripts in untreated cells have a very short half-life (approximately 45 min) although transcripts in TPA-treated cells have a half-life exceeding 3 h. These findings indicate that GM-CSF production in EL-4 cells treated with TPA is regulated predominantly by modulation of cytoplasmic mRNA half-life.
THE ASSASSINATION OF KING HUMBERT.
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Rupture
Authors: Donovan McAbee
Journal: JAMA (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bone marrow sarcoidosis
Authors: P. M. Browne
Journal: JAMA (1978)

Five patients' bone marrow was involved with sarcoidosis, but their chest roentgenograms were normal. The diagnosis was substantiated by typical histological appearance of noncaseating granulomas in bone marrow, careful exclusion of infectious disease, and follow-up study for three to six years. Angiotensin-converting enzyme levels were elevated in all patients at the time of diagnosis. (<i>JAMA</i>240:2654-2655, 1978)
A Rededication?
Authors: John P. Bowler
Journal: New England Journal of Medicine (1953)

IT has been said that presidential addresses are either a scattering of the philosophical pearls of dotage or the indecent exposure of one's mind. I trust this address may fall into the latter rather than the former category. Perhaps it would therefore not be considered too indecent to give the background of that mind.Being among the youngest of our generation, we were at each stage perhaps the more impressionable. From a somewhat distracted medical education during World War I, we have possibly never recovered. And then came the first post-war depression. During that period we were exposed to a . . .
Atypical presentations of patients with calcific aortic stenosis. Patients with normal ECG and patients with associated systemic hypertension
Authors: A. D. Forker
Journal: JAMA (1970)

The diagnostic problems of atypical presentation in two patients with severe aortic stenosis, one without evidence of left ventricular hypertrophy (LVH) on electrocardiogram or x-ray film of the chest and one with significant systemic hypertension, led to a search for similar patients. Of 59 adult patients with severe aortic stenosis confirmed by cardiac catheterization, nine had a normal ECG (with Sokolow-Lyon voltage criteria for LVH) and five had sustained diastolic hypertension. Other voltage criteria were applied to the nine patients with normal ECGs; two showed no LVH by any criteria. Five of the 59 patients had sustained diastolic systemic hypertension (diastolic cuff pressures greater than 100 mm Hg) and presented as clinical diagnostic problems. Cardiac catheterization confirmed severity of aortic stenosis in all. Although unusual, severe aortic stenosis may be associated with a normal ECG and systemic hypertension.
IODIN AND SIMPLE GOITER
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Biology of Mental Health and Disease: The Twenty-Seventh Annual Conference of the Milbank Memorial Fund.
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
生殖器银屑病的患病率和影响
Authors: M. Larsabal, S. Ly, E. Sbidian, M. Moyal‐Barracco, J.‐N. Dauendorffer, N. Dupin, M.A. Richard, O. Chosidow, M. Beylot‐Barry
Journal: British Journal of Dermatology (2019)

银屑病是一种常见的慢性炎症性皮肤病,影响大约 3% 一般人群,在进行此研究的法国影响大约 250 万人。生殖器区域可能被影响,但对其患病率了解甚少,这意味着我们不知道此病到底有多常发生。尽管影响生活质量,对生殖器银屑病的了解不足,很可能由于患者不愿意讨论生殖器的累及和性生活质量。这项被称为 GENIPSO 研究的目的是确定生殖器银屑病的患病率、临床特征(其症状)、是否与特定类型银屑病有关以及对生活质量的影响。这项研究纳入了 776 名在 2016 年 11 月和 2017 年 3 月之间因银屑病来看医生的成人。其中 336 (43.2%) 人有生殖器银屑病。所有这些患者都知道他们的生殖器部位有银屑病(生殖器皮损),但只有 135 (40%) 人曾进行过生殖器医学检查。生殖器皮损与男性性别、更严重的银屑病、首次发生银屑病时年龄大于 20 岁、皮肤皱褶部位银屑病、头皮银屑病、甲和外耳(耳)道银屑病相关(有关),但与肥胖或银屑病关节炎无关。瘙痒是主要症状。生殖器银屑病与生活质量与性健康下降相关。这项研究发现,在因银屑病来看医生的患者中,生殖器银屑病的患病率总体较高,此病影响生活质量,为了能给患者提供最好的治疗,皮肤科医生最好考虑这一点。
PHYSICIAN'S RIGHT TO REFUSE CALLS.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PDCT-01. TOXICITY AND OUTCOME IN ADOLESCENT AND YOUNG ADULTS TREATED FOR MEDULLOBLASTOMA AND PRIMITIVE NEUROECTODERMAL TUMORS ON STUDIES COG-A9961 AND CCG-99701: A REPORT FROM THE CHILDREN’S ONCOLOGY GROUP (COG)
Authors: Shadi Farzingohar, Caihong Xia, Richard Sposto, David Freyer, Girish Dhall
Journal: Neuro-Oncology (2016)

Adolescent and young adults (AYA) with cancer have inferior outcomes compared with younger patients. We explored whether treatment-related toxicity and survival were associated with age in patients with medulloblastoma (MB) and primitive neuroectodermal tumor (PNET) enrolled on children’s oncology group (COG) studies COG-A9961 and CCG-99701. A retrospective analysis was conducted to compare the outcomes between AYA (15-21 years) vs. younger patients (3-14 years). On CCG-99701, 161 patients (16 AYA) with high-risk MB/PNET were treated with chemoradiotherapy followed by six cycles of maintenance chemotherapy cyclophosphamide/cisplatin/vincristine). On A9961 study, 379 patients with standard-risk MB (25 AYA) received chemoradiotherapy followed by eight cycles of maintenance chemotherapy (cisplatin/CCNU/vincristine). On CCG-99701, estimated 5-year event-free survival (EFS) and overall survival (OS) rates were lower for AYA patients (EFS: 37.5% versus 60.3%, p=0.05; OS: 50.0% versus 70.8%, p=0.005). On multivariate analysis, the observed difference in EFS was not statistically significant (p=0.12) but was still consistent with poorer outcome in older patients (HR 1.75, 95% CI 0.89-3.45) after adjustment for extent of resection and pathology. This difference was mainly due to poorer survival for AYA patients with PNET compared to patients 3-14 years of age (55.7% versus 9.1%; p=.002) as there was no significant difference in survival for high-risk medulloblastoma patients (p=0.26). Peripheral neuropathy was higher among AYA as well. On A9961, there was no difference in EFS or OS between AYA and younger patients. Interestingly, the AYA group experienced less hearing loss. Future studies examining the age-related differences in pharmacokinetics of chemotherapy and differences in tumor molecular biology are necessary.
Abstract 890: Feed-forward Signaling of TNF alpha and NFkappa B Produces Endothelial Dysfunction in Coronary Arterioles In Type Ii Diabetic Mice.
Authors: Jiyeon Yang, Xiangbin Xu, Glen A Laine, Cuihua Zhang
Journal: Circulation (2007)

Nuclear factor-κB (NFκB) signaling reportedly increases tumor necrosis factor-alpha (TNF expression), and the oxidative stress induced by TNF may then lead to further increase NFκB expression, i.e., a feed-forward interaction. Accordingly, we hypothesized that this feed-forward interaction between TNF and NFκB may amplify one another toward the evolution of vascular disease in diabetes. To test this hypothesis, we assessed the role of NFκB in endothelial dysfunction in Lepr db mice by evaluation of endothelial function of isolated coronary resistance vessels of m Lepr db (heterozygote, normal) and Lepr db (homozygote, diabetic) mice. Coronary arterioles (40 –100 μm) were isolated and pressurized (60 cmH2O) without flow. Although dilation of vessels to the endothelium-independent vasodilator, sodium nitroprusside (SNP) was not different between Lepr db and m Lepr db mice (n = 6), dilation to the endothelium-dependent agonist, acetycholine (ACh) was reduced (n = 5, P &lt; 0.05). Electron Paramagnetic Resonance (EPR) results show that superoxide production was reduced by NFκB antagonist (MG-132), or anti-TNF in Lepr db mice suggesting that NFκB and TNF were contributing to elevated oxidative stress. MG-132 (1 μM, n = 4) antagonized the inhibitory effect of Lepr db mice on ACh-induced dilation vs. Lepr db without treatment, but did not affect dilation in m Lepr db mice. To better understand the basis for enhanced contributions of TNF and NFκB in diabetes, we used Western analysis to assess expression of major proteins involved in TNF-mediated signaling. Previous studies have provided compelling evidence that IKK beta plays an essential role in NFκB activation in response to TNF, whereas IKK alpha appears to play a lesser role; therefore, we examined the expression levels of IKK alpha and IKK beta mRNA and protein in Lepr db null for TNF. The protein concentration and mRNA expression level of IKK alpha were increased in Lepr db mice null for TNF (db TNF- /db TNF- ) mice. One intriguing finding of this study is that the roles of IKK alpha and IKK beta appear reversed in the inflammatory response in diabetic Lepr db mice. Furthermore, our results indicate that NFκB and TNF signaling interact to amplify the oxidative stress and induce endothelial dysfunction in type II diabetes.
Decoy Oligodeoxynucleotides, Polysaccharides, and Targeted Peptide‐Functionalized Gold Nanorods for the Combined Treatment of Rheumatoid Arthritis
Authors: Nan Zhang, Shasha Zhang, Chunyu Xu, Lingling Fu, Tuanbing Liu, Yongxing Zhao
Journal: Advanced Healthcare Materials (2019)

Adv. Healthcare Mater. 2018, 7, 1800982 The above article, published online on 04 November 2018 in Wiley Online Library (https://wileyonlinelibrary.com), has been retracted by agreement between the authors, the journal Editor-in-Chief, and Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. The retraction has been agreed due to errors in data presentation and non-reproducibility of the results. N. Zhang, S. S. Zhang, C. Y. Xu, L. L. Fu, T. B. Liu, Y. X. Zhao, Adv. Healthcare Mater. 2018, 7, 1800982, DOI:10.1002/adhm.201800982.
Health USA
Authors: E. Richard Brown
Journal: JAMA (1992)

The Health USA Act of 1991 addresses two fundamental health services financing problems: the more than 30 million uninsured persons and the rising costs for health care and for health insurance. Health USA would provide coverage of the entire resident population for comprehensive medical and preventive health and long-term care services through a universal tax-funded financing system. The federal government would contribute an average of 87% of program costs to each state, which would establish, under federal guidelines, a state health program. Each individual or family may enroll in any health plan approved by the state program, including many private plans, or a plan run by the state program. Through the approved plan of their choice, enrollees would receive covered services and obtain their care from participating physicians and other professional practitioners, hospitals, and other facilities. The state program would pay approved plans a capitation payment for every person enrolled. The plans would pay professional providers fees, as part of an all-payer system of fee schedules and expenditure targets, or capitation payments or salary. Hospitals would be financed through global budgets negotiated by the state program with each hospital. The plan run by the state program would pay the health care costs of any person who does not enroll in an approved plan, making the state plan the payer of last resort and eliminating uncompensated care and cost shifting by providers. Health USA would separate health care coverage from employment, ensuring uninterrupted coverage and eliminating employers' administrative role in providing coverage. Federal and state taxes would replace present methods of financing by private insurance premiums and large out-of-pocket expenditures. Building on the present system of health plans, Health USA would offer all persons a wide choice of competing plans in which to enroll and offer professional providers a wide choice of plans in which to practice. It would control costs by increasing financial accountability of providers and health plans, reducing present reliance on intrusive utilization review and on patient cost sharing. By controlling health care and administrative costs, Health USA would cover the entire population and, according to independent cost estimates, reduce national health expenditures by $11.5 billion in 1991. (<i>JAMA</i>. 1992;267:552-558)