tbuckley/cabot-search huggingface dataset:
Abstract P220: Plasma Trans-fatty Acids and Metabolic Syndrome Among US Adults: Findings From NHANES 1999-2000 and 2009-2010
Authors: Zefeng Zhang, Cathleen Gillespie, Quanhe Yang
Journal: Circulation (2017)

Background: Previous studies examined the association between trans-fatty acids (TFAs) and individual components of metabolic syndrome, not simultaneously. In addition, no study has examined if the relationship might become undetectable after significant reduction in TFA intakes. Objective: To examine and compare the association between plasma TFA levels and metabolic syndrome before and after the U.S. Food and Drug Administration enacted food labeling regulations for TFAs in 2006. Methods: We used data on 1442 and 2233 adults aged 20 years or older from NHANES 1999-2000 and 2009-2010, respectively. Multivariable logistic regression analysis was used to assess the association between plasma TFAs concentration and metabolic syndrome and each of its five individual components. Results: The median plasma TFAs level was reduced from 79.8 μmol/L in 1999-2000 to 36.9 μmol/L in 2009-2010. The adjusted prevalence ratios comparing the highest quartile vs. those in the lowest quartiles of plasma TFAs concentration in 1999-2000 were 3.45 (95% confidence interval, 2.42-4.92) for metabolic syndrome, 1.71 (1.37-2.13) for large waistline, 8.45(6.62-10.77) for high triglycerides level, 1.96 (1.48-2.59) for low HDL cholesterol level, 1.14 (0.85-1.52) for high blood pressure, and 1.49 (1.19-1.85) for high fasting blood sugar, respectively. The corresponding adjusted prevalence ratios in 2009-2010 were 2.92 (2.41-3.54), 1.62 (1.40-1.88), 15.10 (9.39-24.30), 3.09 (2.19-4.37), 1.27 (1.11-1.47), and 1.24 (1.06-1.46), respectively. The observed associations were consistent across age groups, sexes, race-ethnicities, education, dietary intake, physical activity, body mass index, and statin use categories. Conclusions and Relevance: Plasma TFAs concentration was positively associated with risk of metabolic syndrome and its individual components except for blood pressure in 1999-2000. Our findings support initiatives to remove TFAs from industrially-produced foods.
Net Tuberculosis Mortality in 46 Large American Cities for Year 1939. Tuberculosis Deaths Allocated to Residence. Proportion of Deaths Among White and Negro Residents
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sueño
Authors: Laura Kunberger
Journal: JAMA (1986)

I lie on my side, Wanting to run from Your confession. You try To pull me toward you but I lie very still, until I dream: I am in Toledo and the night sky is bright With shadows, as El Greco painted it. An old wind blows over The stones of the cathedral, Priests stalk the narrow streets, Looking fretfully down at the hems of their robes. I pace outside, dripping with fever, Knowing— you have taken Someone in my place. Your blue eyes below her dark ones, Her hair falls to your chest— Your hands, her voice, its accent— The sculpture on the tympanium Repeats the scene and I watch in fascination Until it is morning. I climb into the Cool darkness and walk toward Candle flames illuminating The Virgin's downcast eyes. The sweat freezes to my skin. I drop a coin in the box, Light a candle and
Morbidity in an Immigrant Population
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SECTARIANISM IN MEDICINE.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Incorrect Listing
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Polypodium fern wreaths (Hagnaya). A new source of occupational mite dermatitis
Authors: W. B. Shelley
Journal: JAMA (1985)

SOLVING the mystery of an unexplained dermatitis calls not only for informed curiosity on the part of the physician, but also for careful detective work on the part of a well-instructed patient. In this instance, the combination of these two avenues of inquiry led to an awareness of a new vector for skin disease. <h3>Report of a Case</h3> A 21-year-old man presented with a pruritic erythematous eruption of the volar forearms, lower parts of the legs, and eyelids, present with increasing severity for 12 days. It had appeared suddenly within hours of returning from vacation to his work in a wholesale florist supply shop. Severe pruritus had prevented him from working for the past six days. He had worked for six years in this shop, with only one prior attack of dermatitis occurring four months previously. The cause had remained unexplained and he had been treated successfully with intramuscular steroid
Does noninvasive staging of fibrosis challenge liver biopsy as a gold standard in chronic hepatitis C?
Authors: Chun-Tao Wai, Anna S. F. Lok
Journal: Hepatology (2004)

We thank Berg et. al. for the interest expressed on our article.1 We are grateful that many investigators like Berg et. al. had tested our prognostic model in their patient populations.2, 3 Using the aspartate aminotransferase to platelet count ratio index (APRI), significant fibrosis could be identified or excluded in 57.5% of Berg's patients with 82% sensitivity and 93% specificity, and cirrhosis could be identified or excluded in 82.5% of patients with 69% sensitivity and 93% specificity. The specificities were almost identical to those in our study, while the sensitivities were lower. The proportion of patients who fell into the classifiable group was higher than in our study. We agree that the diminished sensitivities may be related to the use of a different fibrosis scoring system, as well as multiple versus single pathologists scoring the biopsies. It is also possible that the inclusion of stage 3 in the Scheuer4 scoring system (fibrosis with architectural distortion but no obvious cirrhosis) as cirrhosis may have affected the accuracy of prediction of cirrhosis. We agree that interobserver or intraobserver variability and size of the biopsies may affect histological interpretation. Because liver biopsies are not necessarily gold standards for assessing liver histology, noninvasive models will not have complete concordance with histological staging. We agree that neither liver biopsy nor noninvasive model is necessary when the severity of the patients' chronic liver disease is obvious, as in the case of patients with decompensated cirrhosis. However, differentiating mild from moderate fibrosis, and moderate fibrosis from well-compensated cirrhosis may be difficult even for experienced hepatologists. Thus, there remains a role for simple noninvasive models that will help in providing more reliable estimates of the stage of liver disease than a clinician's intuition. Chun-Tao Wai*, Anna S. F. Lok*, * University of Michigan, Ann Arbor, MI.
Factitial Weber-Christian syndrome
Authors: A. B. Ackerman
Journal: JAMA (1966)

A unique psychocutaneous syndrome characterized by relapsing febrile nodular nonsuppurative panniculitis was seen in a teenage girl. Her disease, thought to be Weber-Christian syndrome clinically and pathologically, was eventually discovered to be caused by self-injections of milk. The bizarre pattern of typical factitial dermatitis is easily recognized, but exceptional cases may closely resemble authentic disease. Although factitial dermatitis may be associated with many different psychiatric conditions, the highest suspicion should be reserved for the hysterical personality. The characteristic behavior of the hysterical personality can alert the clinician to the possibility of factitial dermatitis.
Antihistaminics and Burns
Journal: BMJ (1951)

EDICS JO9NAL9because his study confirmed that a very large proportion of these patients-but not all of them-suffered from peptic ulcer.Although I consider haematemesis in hospital the most important of all indications, w-hen age is also considered I do not think it the right procedure.To me the question of the objective accuracy required and possible in the diagnosis of peptic ulcer before operation is performed, and the timing of the operation, are the most important problems.My material has been submitted to a further analysis and the indications have been amended somewhat.5-Iam, etc.,
Growth rate in the detection and prognosis of bronchogenic carcinoma
Authors: W. Weiss
Journal: JAMA (1966)

Volume-doubling time was used as an index of growth rate for 18 solitary nodules due to bronchogenic carcinoma. This series from the Philadelphia Pulmonary Neoplasm Research Project was limited to cases whose tumors could be measured on serial chest x-ray films and in whom death, if it occurred, was attributable to the cancer. The distribution of doubling times suggests that, if lung cancer is to be detected soon after it reaches roentgenographic visibility, the interval between serial films must be less than six months in many cases. Whether such a program would improve the cure rate remains to be determined. Doubling time was plotted against survival measured from the time when the cancer was 1 cm in diameter. The slower the growth rate, the longer was the survival.
Transactions of the Southern Surgical and Gynecological Association, Vol. x. Tenth session held at St. Louis, Mo., Nov. 9, 10 and 11, 1897.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Thyroid hormone–sympathetic interaction and adaptive thermogenesis are thyroid hormone receptor isoform–specific
Authors: Miriam O. Ribeiro, Suzy D. Carvalho, James J. Schultz, Grazia Chiellini, Thomas S. Scanlan, Antonio C. Bianco, Gregory A. Brent
Journal: Journal of Clinical Investigation (2001)

In newborns and small mammals, cold-induced adaptive (or nonshivering) thermogenesis is produced primarily in brown adipose tissue (BAT). Heat production is stimulated by the sympathetic nervous system, but it has an absolute requirement for thyroid hormone. We used the thyroid hormone receptor-beta--selective (TR-beta--selective) ligand, GC-1, to determine by a pharmacological approach whether adaptive thermogenesis was TR isoform--specific. Hypothyroid mice were treated for 10 days with varying doses of T3 or GC-1. The level of uncoupling protein 1 (UCP1), the key thermogenic protein in BAT, was restored by either T3 or GC-1 treatment. However, whereas interscapular BAT in T3-treated mice showed a 3.0 degrees C elevation upon infusion of norepinephrine, indicating normal thermogenesis, the temperature did not increase (<0.5 degrees C) in GC-1--treated mice. When exposed to cold (4 degrees C), GC-1--treated mice also failed to maintain core body temperature and had reduced stimulation of BAT UCP1 mRNA, indicating impaired adrenergic responsiveness. Brown adipocytes isolated from hypothyroid mice replaced with T3, but not from those replaced with GC-1, had normal cAMP production in response to adrenergic stimulation in vitro. We conclude that two distinct thyroid-dependent pathways, stimulation of UCP1 and augmentation of adrenergic responsiveness, are mediated by different TR isoforms in the same tissue.
Lectures on the Compressed Air Bath and its Uses in the Treatment of Disease
Authors: C. T. Williams
Journal: BMJ (1885)

THE BITISH MJDICAM'JOOUNIL.7M down a long flight of stone-stairs, but had determined not to say4anything about it to aiiy one.In acute cases such as this, then, I tbink the course of the surgeon is quite clear.He may find a band, or some temporary obstruction, which he may be able to relieve; he may find an intussusception, which he may be able to unfold ; or an internal hernia, of some kind such as I have described.Much more difficult cases to deal with are those of slower develop- ment, and less urgency of distress; such as may arise from occlusion by faecal accumulation, by some localised inflammation, by chronic invagination, or by implication in some diseased process, not inherent in the intestine itself, but in surrounding parts, and involving it.In
Activation of Chemicals into Mutagens by Green Plants: A Preliminary Discussion
Authors: Michael J. Plewa
Journal: Environmental Health Perspectives (1978)

This paper is a review of recent studies that demonstrate the activation of chemicals (especially pesticides into mutagens by green plants. Such activation of pesticides may be hazardous to the public health because of their widespread use in agriculture and the current lack of information that exists about such processes. The mutagenic properties of the s-triazine herbicides (atrazine, simazine, and cyanazine) as exhibited in various assay systems are discussed. In vivo, in vitro, and in situ plant assays are presented, and the maize wx locus assay is discussed.
Cardiovascular Physiology
Authors: David H. Spodick
Journal: JAMA (1972)

This compact text succeeds admirably in its declared aim of delineating for medical and other graduate students the essentials of cardiovascular function. Eleven succinct chapters cover general concepts with emphasis on control mechanisms, while the 12th chapter demonstrates how these operate as a whole in response to illustrative interventions, both physiologic (exercise) and pathologic (hemorrhage). With the exception of the latter, and earlier consideration of atrioventricular and intraventricular blocks, the text is confined to normal physiology. The authors have deliberately simplified their approach. Footnotes and documentary references are largely omitted as are the relatively minor embellishments which would have required them. Recommended reading at the end of each chapter includes well-chosen general and review articles. Thus, broad principles are effectively communicated, giving the reader a satisfactory framework for clinical understanding on which he can build in areas in which he may later wish to penetrate more deeply. It is difficult
Lymphadenectomy for testicular tumors
Authors: W. L. Caldwell
Journal: JAMA (1971)

<h3>To the Editor.—</h3> The recent paper on retroperitoneal lymphadenectomy for testicular tumors by Walsh et al (<b>217</b>:309, 1971) reported excellent results which undoubtedly represent maximal survival rates possible from this procedure, since it is done by individuals with considerable experience and expertise. Several aspects of the report could stand clarification. First, the number of patients explored and found non-resectable is not stated; such patients should clearly be included as failures of the technique. In an earlier report from Walter Reed Army Hospital by Patton and Mallis, 31 of 162 patients were found to have nonresectable disease in the retroperitoneal space. Surely, the UCLA experience must include some patients with nonresectable disease. Only a fourth of the patients (16) received postoperative irradiation. How these 16 patients were selected from the 35 patients with involved lymph nodes at the time of adencetomy is not stated. In the absence of this information
Optimal sequencing of enzalutamide and abiraterone in men with metastatic castration-resistant prostate cancer (mCRPC).
Authors: Benjamin Louis Maughan, Daniel L. Suzman, Rosa Maria Nadal, Sunakshi Bassi, Emmanuel S. Antonarakis
Journal: Journal of Clinical Oncology (2016)

308 Background: Both enzalutamide and abiraterone are approved for the treatment of mCRPC, each demonstrating improved overall survival (OS) versus placebo. However, it is unclear what the optimal sequencing of these two therapies should be to maximize clinical outcomes and survival. Here, we compare clinical outcomes among patients with mCRPC who received enzalutamide first followed immediately by abiraterone (enza-to-abi) or the opposite sequence (abi-to-enza). Methods: A retrospective review of consecutive mCRPC patients treated at Johns Hopkins with enza-to-abi or abi-to-enza was conducted. The combined PFS (PFS = PFS1 + PFS2) was the primary endpoint, measured from the start of the first therapy (i.e. enza or abi) until disease progression on the subsequent therapy (i.e.abi or enza). The OS from the start of the first therapy until death was the secondary endpoint. Cox proportional hazards multivariable regression analysis was performed to determine whether one sequence was better than the other after adjusting for baseline characteristics. Results: 71 patients were identified: 58 received abi-to-enza and 13 received enza-to-abi. Comparisons of baseline characteristics between groups identified differences in PSA levels (P = 0.007), hemoglobin (P &lt; 0.001), and presence of visceral disease (P = 0.035). The abi-to-enza group had a longer combined PFS than the enza-to-abi group: median 16.3 vs 12.5 mo (HR 0.53, P = 0.04). There was also a numeric improvement in OS in the abi-to-enza group compared to the enza-to-abi group: median 29.0 vs 21.0 mo (HR 0.51, P &lt; 0.10). In multivariable analyses incorporating PSA level, hemoglobin, visceral disease and prior docetaxel use, both combined PFS (HR 2.59, P = 0.03) and OS (HR 4.59, P &lt; 0.01) demonstrated improved outcomes with the abi-to-enza sequence. Conclusions: This hypothesis-generating study potentially suggests superior PFS and OS in men with mCRPC receiving abiraterone then enzalutamide (compared to enzalutamide then abiraterone), although this could be due to baseline imbalances or the small sample size of this study. Prospective validation of this concept is ongoing (NCT02125357).
Introductory clerkships and the community hospital
Authors: P. F. Griner
Journal: JAMA (1969)

As medical school-community hospital affiliations begin to flourish, it is likely that student assignments to the affiliate will be made at earlier stages of the curriculum. To this end, a number of prerequisites must be met in order to ensure a meaningful experience for the student. These include the definition of student goals and responsibilities; an informed and interested hospital administration and attending staff; proper communication of these aims to patients, house staff, and attending physicians; effective use of teaching talent (supplemented, when necessary, by the medical school); adequate student facilities; and resolution of logistic problems in the curriculum that tend to fragment the student's experience at the community facility. We have found some methods useful in resolving these difficulties.