tbuckley/cabot-search huggingface dataset:
Pneumocystis carinii pneumonia in a previously healthy adult
Authors: R. E. Waldhorn
Journal: JAMA (1982)

THE OCCURRENCE of<i>Pneumocystis carinii</i>pneumonia in normal adults has been reported only rarely; it is almost exclusively a disease of immunocompromised hosts.<sup>1</sup>A case of a previously healthy adult with fatal<i>P carinii</i>pneumonia, documented by open lung biopsy and necropsy, who was treated unsuccessfully with trimethoprim-sulfamethoxazole and pentamidine isethionate, is presented. <h3>Report of a Case</h3> A 38-year-old homosexual man was in excellent health until July 1980, two months before admission to the hospital, when recurrent sore throats, anorexia, and dyspnea began. These symptoms continued; one week before admission, fever, night sweats, headache, and a nonproductive cough developed. Progressive fever to 39.4 °C, substernal chest pain, and dyspnea on minimal exertion led to his admission. No coryza, myalgias, arthralgias, or mental changes were noted. The patient appeared ill; respirations were 36/min; pulse rate, 88 beats per minute; and temperature, 40.3 °C. Results of the physical examination were otherwise
The pruritus of cholestasis and the opioid system
Authors: E. A. Jones
Journal: JAMA (1992)

<h3>SELECTED CASE</h3> A year after being told that she had abnormal liver test results, a 52-year-old white woman presented with increasing fatigue, pruritus, diffuse abdominal pain, and jaundice. Although endoscopic retrograde cholangiopancreatography was indicated, a diagnostic laparotomy was undertaken. An intraoperative cholangiogram revealed beading and narrowing of intrahepatic and extrahepatic bile ducts characteristic of primary sclerosing cholangitis. Cholecystectomy, exploration of the common bile duct, and endoscopic dilation of large-duct biliary strictures were performed. During the ensuing 12 months the pruritus became severe. Her entire body itched; she slept poorly and felt like she was "on a cactus bed." She scratched until she bled, but scratching did not relieve the pruritus. Conventional doses and schedules of cholestyramine, hydroxyzine hydrochloride, and ursodeoxycholic acid had failed to provide her with relief and her pruritus was considered to be intractable. When referred to the National Institutes of Health, she was scratching continuously and was
<i>Cronobacter</i>Infections More Prevalent Than Expected
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SHIGELLOSIS
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Grundlagen der ätiologischen Behandlung der Nierenentzündungen.
Journal: JAMA (1930)

This monograph is divided into three parts. The first part covers a careful study of a large series of cases of acute and chronic glomerulonephritis during life and post mortem showing the close relationship between these diseases and foci of infection in various parts of the body. Part II is a discussion and presentation of case reports demonstrating the almost constant finding of infectious foci in cases of nephritis. The various infections of the upper respiratory tract, particularly, and also those of other parts of the body are closely linked to nephritis as the etiologic factors. The third portion relates to the treatment of these foci wherever found. Diffuse glomerulonephritis should not be considered merely an endresult of an infectious process but is due to persistent low grade infectious foci which, if eradicated, may result in cure. If the usual treatment of acute nephritis, such as rest in bed, limitations
Sixth Plot of the Carcinogenic Potency Database: Results of Animal Bioassays Published in the General Literature 1989 to 1990 and by the National Toxicology Program 1990 to 1993
Authors: Lois Swirsky Gold, Neela B. Manley, Thomas H. Slone, Georganne Backman Garfinkel, Bruce N. Ames, Lars Rohrbach, Bonnie R. Stern, Kenneth Chow
Journal: Environmental Health Perspectives (1995)
Innate Immunity
Authors: Ruslan Medzhitov, Charles Janeway
Journal: New England Journal of Medicine (2000)

The immune system has traditionally been divided into innate and adaptive components, each with a different function and role. The adaptive component is organized around two classes of specialized cells, T cells and B cells. Since each lymphocyte displays a single kind of structurally unique receptor, the repertoire of antigen receptors in the entire population of lymphocytes is very large and extremely diverse. The size and diversity of this repertoire increase the probability that an individual lymphocyte will encounter an antigen that binds to its receptor, thereby triggering activation and proliferation of the cell. This process, termed clonal selection, accounts . . .
Error in a Data Point in Table 3
Journal: JAMA Oncology (2019)

Jeffrey S. Ross, MD; Kai Wang, MD, PhD; Laurie Gay, PhD; Geoff A. Otto, PhD; Emily White, BS; Kiel Iwanik, BS; Gary Palmer, MD; Roman Yelensky, PhD; Doron M. Lipson, PhD; Juliann Chmielecki, PhD; Rachel L. Erlich, PhD; Andrew N. Rankin, PhD; Siraj M. Ali, MD, PhD; Julia A. Elvin, MD, PhD; Deborah Morosini, MD; Vincent A. Miller, MD; Philip J. Stephens, PhD
COPPER IN HUMAN HEMATOPOIESIS
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Do Women with Heart Attacks Get Fewer Heart Procedures Than Men?
Journal: Annals of Internal Medicine (2002)

Summaries for Patients17 September 2002Do Women with Heart Attacks Get Fewer Heart Procedures Than Men?Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-137-6-200209170-00002 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Heart attacks occur when blood flow through the arteries to the heart (coronary arteries) is blocked for a long enough time to damage or kill a portion of heart muscle. Within days to months after the heart attack, doctors sometimes inject dye through a catheter into the coronary arteries (heart catheterization) to see where they are narrowed or blocked. Doctors do the catheterization to find out whether patients need major procedures (coronary artery bypass graft surgery or angioplasty) to help prevent future heart attacks and chest pain (angina). ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Sex Differences in Cardiac Catheterization after Acute Myocardial Infarction: The Role of Procedure Appropriateness.” It is in the 17 September 2002 issue of Annals of Internal Medicine (volume 137, pages 487-493). The authors are SS Rathore, Y Wang, MJ Radford, DL Ordin, and HM Krumholz.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoSex Differences in Cardiac Catheterization after Acute Myocardial Infarction: The Role of Procedure Appropriateness Saif S. Rathore , Yongfei Wang , Martha J. Radford , Diana L. Ordin , and Harlan M. Krumholz Metrics 17 September 2002Volume 137, Issue 6Page: I-26KeywordsCardiac surgeryCatheterizationCoronary arteriesForecastingHeartIschemiaLiverMedicareMyocardial infarctionMyocardium ePublished: 17 September 2002 Issue Published: 17 September 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Naturally-Occurring Mutation in the Calcium-Sensing Receptor Reveals the Significance of Extracellular Domain Loop III Region for Class C G Protein-Coupled Receptor Function
Authors: Qing Dong, Zhiqiang Cheng, Wenhan Chang, Brigitte E. Blackman, Felix A. Conte, Jianxin Hu, Dolores Shoback, Walter L. Miller
Journal: Endocrine Reviews (2010)

Inactivating mutations of the calcium-sensing receptor (CaSR) cause familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism. Most mutations are clustered in the N-terminal and Cys-rich regions of the extracellular domain (ECD) and seven-transmembrane domain. Disease-causing mutations are uncommon in the C terminus of ECD. The aim of the study was to characterize the CaSR mutations causing neonatal severe hyperparathyroidism in a consanguineous family. Parathyroid glands from the index patient were stained for CaSR protein. The CaSR gene was sequenced, mutations were recreated in CaSR cDNA, and HEK293 cells were transfected with the CaSR mutant expression vector. Cellular CaSR targeting was detected by immunoblotting and immunocytochemistry; CaSR activity was assayed by inositol phosphate accumulation, MAPK activation, and single-cell microfluorimetry. Immunocytochemistry showed reduced intracellular CaSR in patient parathyroids. An in-frame homozygous deletion/insertion mutation, c.1031 > 1034 (delACAAinsT), replaced His344-Asn345 with a single Leu in CaSR loop III. The mutant reduced cell surface expression of CaSR in transfected HEK293 cells. Inositol phosphate accumulation, MAPK activation, and single-cell microfluorimetry revealed blunted signaling responses of the mutant receptor to changes in extracellular Ca2+ concentration. Deletion of His344-Asn345 in the ECD loop III region affects cell surface targeting of CaSR in transfected cells and in affected parathyroid glands. Absence of conserved Asn345 may interfere with CaSR folding or glycosylation, leading to poor protein targeting to the cell membrane. This loss-of-function mutant indicates that the ECD loop III is required for CaSR activity.
Transmission of Nosocomial Legionnaires Disease
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Efficacy and Safety Of Ponatinib Following Failure Of Nilotinib In Patients With Chronic Phase Chronic Myeloid Leukemia (CP-CML) In The PACE Trial
Authors: Hagop M. Kantarjian, Jorge E. Cortes, Dong-Wook Kim, Javier Pinilla-Ibarz, Philipp D. le Coutre, Ronald Paquette, Charles Chuah, Franck E. Nicolini, Jane F. Apperley, H Jean Khoury, Moshe Talpaz, John F. DiPersio, Daniel J. DeAngelo, Elisabetta Abruzzese, Delphine Rea, Michele Baccarani, Martin C. Müller, Carlo Gambacorti-Passerini, Stephanie Lustgarten, Victor M. Rivera, Tim Clackson, Christopher D. Turner, Frank G. Haluska, Francois Guilhot, Michael W. Deininger, Andreas Hochhaus, Timothy P. Hughes, John M. Goldman, Neil P. Shah
Journal: Blood (2013)
SURVEY OF PHYSICIAN ATTITUDES
Journal: JAMA (1953)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Archives of General Psychiatry, Chicago
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
1125 PROGNOSIS OF ACUTE SEVERE AUTOIMMUNE HEPATITIS (AIH): THE ROLE OF CORTICOSTEROIDS IN MODIFYING OUTCOME
Authors: A.D. Yeoman, R.H. Westbrook, W. Bernal, P.M. Harrison, N.D. Heaton, J.A. Wendon, J.G. O'Grady, M.A. Heneghan
Journal: Journal of Hepatology (2010)
Highlights
Journal: JAMA Cardiology (2020)

Safety and Efficacy of Femoral vs Radial Access in STEMI 126Whether radial access or femoral access for primary percutaneous coronary intervention is associated with survival in patients with ST-segment elevation myocardial infarction (STEMI) remains controversial.Le May and coauthors enrolled 2292 patients with STEMI in a randomized clinical trial at 5 percutaneous coronary intervention centers in Canada.The trial was stopped early following a futility analysis.The primary outcome, 30-day all-cause mortality, did not differ between patients assigned to radial access vs femoral access (17 of 1136 [1.5%] vs 15 of 1156 [1.3%], respectively), and there were no differences in rates of reinfarction, stroke, and bleeding.In an Invited Commentary, Sweis places these results in context and notes that the weight of the evidence favors a radial-first approach.
Quinidine-induced lupus nephritis
Authors: M. Yudis
Journal: JAMA (1976)

MANY DRUGS can precipitate a syndrome resembling systemic lupus erythematosus (SLE). The most common are hydralazine hydrochloride, procainamide hydrochloride, and various anticonvulsants. To our knowledge, only two previous cases of quinidine-related lupus have been recorded.<sup>1,2</sup>Our case involved the musculoskeletal system and the kidneys. <h3>Case Report</h3> A 49-year-old woman was first admitted to Holy Redeemer Hospital in August 1970 with a diagnosis of rheumatic mitral stenosis with atrial fibrillation. At that time, the antistreptolysin O titer, hemoglobin value, blood cell count, and urinalysis results were normal. Digoxin therapy was started with a dosage of 0.25 mg daily. The patient was also receiving warfarin sodium (Coumadin), 7.5 mg daily, and meprobamate, 200 mg four times a day. Her rhythm reverted to normal with digoxin therapy. The patient remained well until July 1973, when she was readmitted because of recurrence of atrial fibrillation with an uncontrolled ventricular response. Her treatment consisted
Intrinsic and Estrinsic Mechanism Contributes to Maintain the JAK/STAT Pathway Aberrantly Activated in T-Type Large Granular Lymphocyte Leukemia
Authors: Renato Zambello, Antonella Teramo, Cristina Gattazzo, Francesca Passeri, Albana Lico, Giulia Tasca, Anna Cabrelle, Federica Frezzato, Veronica Martini, Valentina Trimarco, Tamara Berno, Elisa Boscaro, Monica Facco, Livio Trentin, Gianpietro Semenzato
Journal: Blood (2011)
Duodenal intubation
Authors: E. D. Palmez
Journal: JAMA (1975)

MOST PHYSICIANS spend what seems, at the time, to be a substantial part of their training period trying to get tubes into duodenums. Almost always they do it because someone tells them to. They are pretty sure that if the attending physician had to do it himself, he would never order it. They need no hard statistics to be convinced that duodenal intubation is ordered far more often in the teaching hospital than in all the neighboring community hospitals put together. Because passing a tube into the duodenum is often difficult and requires much time (all shot through with uncertainty about where the end of the tube is and which way it is pointing), the procedure is sometimes carried out under fluoroscopic control. To make tube manipulation slicker, pull-wire machines have been devised so the operator can guide the tip as the fluoroscopist directs. But routine use of fluoroscopy for
Water fluoridation and hip fracture
Authors: C. Cooper
Journal: JAMA (1991)

<h3>To the Editor.</h3> — In a recent article inThe Journal, Jacobsen et al<sup>1</sup>demonstrated a positive ecologic association between hip fracture discharge rates in the United States and fluoride content in water supplies. In a similar study, we recently reported the ecological association of discharge rates for hip fracture and water fluoride levels in 39 county districts in England.<sup>2</sup>Our study was performed in response to the suggestion that fluoridation of water might serve to stem the rising tide of hip fracture in western populations. Such a strategy was supported by laboratory evidence that fluoride was a potent inducer of bone formation, and by epidemiologic studies from Finland and the United States demonstrating lower rates of hip fractures associated with higher water fluoride levels. Our analysis demonstrated no significant association between discharge rate and total fluoride concentration (<i>r</i>=.16,<i>P</i>=.34). This lack of association was found
Multiple myeloma
Authors: Michel Delforge
Journal: HemaSphere (2018)

University Hospital Leuven, Belgium This is an open access Abstract Book distributed under the Attribution-NonCommercial-NoDerivs (CCBY-NC-ND), which allows third parties to download the abstracts and share them with others as long as they credit the author and the abstract book, but they cannot change the content in any way or use them commercially. http://creativecommons.org/licenses/by-nc-nd/4.0
Poster Discussions
Authors: L. Brazzi, P. Vercesi, F. Valenza, E. Riva, L. Gattinoni, P. Heinonen, I. Jousela, K. Blomquist, O. Takkunen, B. Temmesfeld, S. Schreiber, A. Szalay, D. Grosse-Meininghaus, F. Dapper, F. Grimminger, W. Seeger, C. D. Gomersall, G. M. Joynt, R. C. Freebairn, M. T. V. Chan, K. K. Young, T. E. Oh, A. Pérez, J. Cánovas, J. Carrasco, R. Carrasco, J. Sánchez, J. Caturla, A. F. Mackenzie, I. S. Grant
Journal: Intensive Care Medicine (1996)
Erratum
Journal: BMJ (1904)

had dealt with suppurative diseases of the ear and their com- plications, and suggested that the Society might well devote a part of its time to a study of chronic non-suppurative diseases which did not endanger life but made it almost unbearahle.It would be of great advantage to otologists to have authorita- tive guidance as to the comparative utility of the various methods of treatment in vogue.