tbuckley/cabot-search huggingface dataset:
The Ropes
Authors: Kimberly D. Manning
Journal: Annals of Internal Medicine (2012)

Ad Libitum6 March 2012The RopesKimberly D. Manning, MDKimberly D. Manning, MDFrom Atlanta, GA 30303.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-156-5-201203060-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail I was asked to show you the ropesto tie together for you those thingsthat seem so foreign right nowso loftyso cryptic and far awayDo you hear that? No?Try listening hereyour face illuminatesthis time you hear itYes, you doI warm my handsYou do the sameSynchronous palms rubbing like musicHands pressing into carefully exposed fleshMine first, then yoursboth of us smiling at the personto whom what is being palpated belongsAppreciative for this teachable momentWhilst remembering who provided itbecause of what you saw me do... Author, Article, and Disclosure InformationAffiliations: From Atlanta, GA 30303.Current Author Address: Kimberly D. Manning, MD; e-mail, [email protected]edu. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMentoring: A Tale of Two Poems, Filling Graveyards, and Learning the Art of MedicineNackenschmerztherapie: Selbst ist der Patient 6 March 2012Volume 156, Issue 5Page: 398 ePublished: 6 March 2012 Issue Published: 6 March 2012 Copyright & PermissionsCopyright © 2012 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Attitudes of radiation oncologists toward palliative and supportive care in the United States: Report on National Membership Survey by the American Society for Radiation Oncology (ASTRO).
Authors: Randy Wei, James B. Yu, Malcolm Mattes, Adrienne Thrasher, Hui-Kuo George Shu, Jennifer F. De Los Santos, Harald Paganetti, Bridget F. Koontz, Christopher Abraham, Tracy A. Balboni
Journal: Journal of Clinical Oncology (2016)

105 Background: Radiation oncologists are frequently involved in providing palliative and supportive care (PSC) for patients with advanced cancers through delivery of palliative radiation. Whether they are confident in their ability to assess and initiate treatments for pain, non-pain, and psychosocial distress is unknown. The American Society for Radiation Oncology (ASTRO) surveyed its practicing members in the United States on self-assessment of their primary PSC skills, and access to continuing medical education on PSC. Methods: We electronically surveyed 4,093 practicing radiation oncologists in the United States. The survey consisted of 17-questions in five sections: demographics, PSC training, domains of PSC, perceived barriers as a radiation oncologist to initiate advanced care planning, and discussion on prognosis. Results: The majority (91%) of radiation oncologists surveyed believe PSC is an important competency for radiation oncologists. Most radiation oncologists reported that they are moderately confident in their ability to assess and manage pain and GI symptoms but less confident in their ability to manage anorexia, anxiety, and depression. Despite areas of decreased confidence, a large number (42%) of radiation oncologists do not receive any additional PSC education beyond their residency training. Lastly, a perceived fear of upsetting referring medical oncologists and lack of clinic time are concerns for radiation oncologists who may want to initiate goals of care/advance care planning discussions with patients and their families. Conclusions: Radiation oncologists are more confident in their ability to assess and manage pain than in their ability to manage depression, anxiety, anorexia, and fatigue. There is a need for increasing continuing medical educational efforts in PSC for practicing radiation oncologists, and strengthening PSC training in residency programs.
MOTOR PHENOMENA OF MANIA AND MELANCHOLIA.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Roentgenographic Manifestations of Joint Disease in Systemic Lupus Erythematosus
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The association of sarcopenia with myostatin, follistatin and irisin levels in cirrhotic patients: a multicenter cross-sectional study
Authors: Salih Boga, Abdullah Emre Yıldırım, Enver Ucbilek, Ali Riza Koksal, Sevil Tokdemir Sisman, Ibrahim Durak, Ilker Sen, Beril Dogu, Erdinc Serin, Ayse Bolat Ucbilek, Makbule Ozge Yildirim, Sukru Mehmet Erturk, Huseyin Alkim, Canan Alkim
Journal: Journal of Hepatology (2020)
Abstract 518: Hypoxia and high interstitial pressure present within the tumor microenvironment can promote T cell suppression and exhaustion
Authors: Chiara Rancan, Rachel Marusinec, James Lim, Lawrence Fong
Journal: Cancer Research (2019)

Abstract Introduction: The tumor microenvironment is thought to be hostile to the optimal functionality of immune cells. In addition to hypoxia, tumors have a higher interstitial pressure than normal tissue. We examined the impact of hypoxia and increased pressure on human T cell function in vitro. We hypothesize that hypoxia and high pressure induced a more profound and durable exhaustion of activated T cells. Methods: We cultivated human healthy PBMCs stimulated with phytohemagglutinin (PHA) or CD3/CD28 beads under tumor hypoxic conditions (1%O2, 2PSI) and compared it to normoxic in vitro culture conditions (20% O2, 0 PSI). We utilized the AVATAR system (Xcellbio), a novel bioreactor with highly customable cultivation conditions that allows for the modulation of oxygen and pressure. Functionality and phenotypic changes induced by different cultivation conditions were assessed by flow cytometry and cytokine release assays. Results: Upon stimulation of PBMCs for 3 days, we observed that hypoxia markedly reduced IFNγ and TNFα cytokine release. Additionally, hypoxia induced an overall decrease in surface expression of the activation and metabolic markers CD71 (transferrin) and CD98 (neutral amino acids transporter), while promoting an increased expression of the inhibitory receptor PD1. This was true for both CD4+ and CD8+ T cells. Following this initial 3-day “priming” stimulation, cells spent 2-days in a “resting period” and underwent a second stimulation under a different condition (cells under normoxia were cultured under hypoxia and vice versa). We found that cells initially primed under hypoxic conditions maintained higher levels of PD1 expression after the second stimulation, regardless of whether the latter condition was normoxic or hypoxic. Conclusions: Taken together these observations suggest that T cell priming in hypoxic and high pressure conditions present in tumors induce an irreversible state of T cell exhaustion and point out a dominant effect of hypoxia over normoxia. Our data suggest that environmental culture conditions greatly affect T cell responses and should be taken into account when studying T cell functionality, especially in the investigation of novel therapeutic agents targeting the immune system. Citation Format: Chiara Rancan, Rachel Marusinec, James Lim, Lawrence Fong. Hypoxia and high interstitial pressure present within the tumor microenvironment can promote T cell suppression and exhaustion [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 518.
Angiosarcoma of the liver associated with diethylstilbestrol
Authors: C. Hoch-Ligeti
Journal: JAMA (1978)

Angiosarcoma of the liver occurred in a 76-year-old man who had been treated for a well-differentiated adenocarcinoma of the liver with diethylstilbestrol for 13 years. Angiosarcoma was also present within pulmonary and renal arteries. The possibility that the intraarterial lesions might represent independent primary tumors is considered. (<i>JAMA</i>240:1510-1511, 1978)
THE FOOD VALUE OF VEGETABLE "GELATINS."
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
1-alpha-hydroxyvitamin D3 in chronic renal failure. A potent analogue of the kidney hormone, 1,25-dihydroxycholecalciferol
Authors: J. C. Chan
Journal: JAMA (1975)

In chronic renal disease, the synthesis of the kidney hormone, 1,25-dihydroxyvitamin D<sub>3</sub>(1,25-[OH]<sub>2</sub>D<sub>3</sub>), is impaired, thus contributing to the development of renal osteodystrophy. The clinical use of 1,25-[OH]<sub>2</sub>D<sub>3</sub>is limited, due to the complexity and expense of its chemical synthesis. This study reports the use of 1-α-hydroxyvitamin D<sub>3</sub>(1-α-OH-D<sub>3</sub>), an active analogue of (1,25-[OH]<sub>2</sub>D<sub>3</sub>, in eight patients with chronic renal failure, five of whom were undergoing long-term hemodialysis. The drug was given orally for 6 to 260 days at a dosage of 1μg to 4μg/day. Short-term (21 days) balance studies showed an increase in intestinal calcium absorption and a simultaneous fall in serum parathyroid hormone levels during administration of 1-α-OH-D<sub>3</sub>. In two long-term studies (160 and 260 days), roentgenographic improvement of renal osteodystrophy was seen after 45 and 185 days, respectively. The data indicate that 1-α-OH-D<sub>3</sub>holds considerable promise for the prevention and treatment of renal osteodystrophy. (<i>JAMA</i>234:47-52, 1975)
Effects of Nifedipine in Achalasia and Patients With High-Amplitude Peristaltic Esophageal Contractions-Reply
Authors: Morris Traube
Journal: JAMA (1985)

<h3>In Reply.—</h3> We thank Dr Román and colleagues for their interest in our article and are pleased to learn that they too have found that in achalasia nifedipine decreased LES pressure but not contraction amplitude. The writers ask why nifedipine decreased contraction amplitude in patients with nutcracker esophagus, or high-amplitude peristaltic contractions, but not in achalasia and suggest that the different basal amplitudes may play a role. We concur that this is a plausible, albeit not well-understood, explanation. Our preliminary observations indicated a greater effect of nifedipine on contraction amplitude in patients with high-amplitude peristalsis than in normal subjects, who nevertheless may also have a significant reduction in amplitude after administration of nifedipine.<sup>1</sup>However, another factor in achalasia may be a technical one: the amplitudes are very low and it may be difficult to demonstrate accurately further reductions after drug dosing. In any event, since the simultaneous contractions in
Skeletal Concentrations of Lead, Cadmium, Zinc, and Silver in Ancient North American Pecos Indians
Authors: Jonathon E. Ericson, Donald R. Smith, A. Russell Flegal
Journal: Environmental Health Perspectives (1991)

Bone samples of 14 prehistoric North American Pecos Indians from circa 1400 A.D. were analyzed for lead, cadmium, zinc, and silver by graphite furnace atomic absorption spectrometry to establish the baseline levels of these elements in an ancient North American population. Measurements of outer and inner bone fractions indicate the former were contaminated postmortem for lead, zinc, and cadmium. The contamination-adjusted average (mean +/- SD) level of lead (expressed as the ratio of atomic lead to atomic calcium) in bones of the Indians was 8.4 +/- 4.4 x 10(-7)), which was similar to ratios in bones of ancient Peruvians (0.9 to 7.7 x 10(-7)) and significantly lower than ratios in bones of modern adults in England and the United States (210 to 350 x 10(-7]. The adjusted average concentrations (microgram per gram dry weight) of biologic cadmium, silver, and zinc in the Pecos Indian bones were 0.032 +/- 0.013, 0.094 +/- 0.044, and 130 +/- 66, as compared to concentrations of 1.8, 0.01 to 0.44, and 75 to 170 in the bones of modern people, respectively. Therefore, cadmium concentrations in Pecos Indian bones are also approximately 50-fold lower than those of contemporary humans. These data support earlier findings that most previously reported natural concentrations of lead in human tissues are erroneously high and indicate that natural concentrations of cadmium are also between one and two orders of magnitude lower than contemporary concentrations.
FERMENTS IN PATHOLOGY.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TARSADENITIS MEIBOMICA.
Authors: M. F. WEYMANN
Journal: JAMA (1901)

<h3>Definition.</h3> —A subacute or chronic infection of the Meibomian glands, tending to periodical acute exacerbations and, secondarily, altering the whole structure of the tarsal cartilages, chiefly the upper. <h3>Etiology.</h3> —Diffusion through part, or all, of the Meibomian glandular system of chalazial disintegration products and their cause. <h3>Pathogenesis.</h3> —Chalazia representing unhealthy granulation tissue of a very low type, scantily supplied with blood vessels, tend, from this nature of their make-up, to break down. The age of the patient and the condition of the general health modify this tendency to disintegration, great youthfulness and general debility favoring a destruction more or less acute, while more advanced age and good health favor chronicity. This circumstance is due merely to varying degrees of body resistance. Chalazia may, therefore, undergo, 1, suppuration; 2, chronic inflammatory softening. 1. Suppuration may be so severe as to bring about not only the destruction of the neoplastic tissue, but
HISTIDIN AND ITS DERIVATIVES IN THE BODY
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Airway constriction in normal humans produced by inhalation of leukotriene D. Potency, time course, and effect of aspirin therapy
Authors: J. W. Weiss
Journal: JAMA (1983)

Five normal human subjects inhaled aerosols generated from solutions of leukotriene D (LTD) to determine the bronchoconstrictor potency and the time course of airway obstruction produced by this constituent of slow-reacting substance of anaphylaxis. The dose-effect and time-effect curves were compared with curves similarly generated for the well-characterized airway constrictor histamine. Leukotriene D was, on average, 5,900 times more potent than histamine on a molar basis in producing an identical decrement in maximal expiratory flow rate at 30% of control vital capacity above residual volume. In addition, although LTD had a rapid onset of effect, similar to that of histamine, the airway obstruction produced by LTD was longer lasting, thereby reflecting more closely the response of asthmatic allergic individuals to antigen inhalation. The response of these subjects to inhalation of LTD was not altered by ingestion of aspirin, suggesting that the airway obstruction was not mediated by cyclooxygenase products of arachidonic acid. (<i>JAMA</i>1983;249:2814-2817)
The Diversity of Neuronal Nicotinic Acetylcholine Receptors
Authors: S. Peter B.
Journal: Annual Review of Neuroscience (1993)

The brain's default mode network consists of discrete, bilateral and symmetrical cortical areas, in the medial and lateral parietal, medial prefrontal, and medial and lateral temporal cortices of the human, nonhuman primate, cat, and rodent brains. Its ...Read More
Poster Session 1: Varices and Bleeding
Journal: Hepatology (2015)

mately 10 hours (Day -1) and 2 hours (Day 1) prior to SD 100 mg GZR/50 mg EBR FDC on Day 1.In Period 3, 40 mg PAN was administered QD on Days 1 to 5 followed by administration of SD 100 mg GZR/50 mg EBR FDC 2 hours after PAN administration on Day 5.There was at least a 10-day washout between periods.PK parameters were determined for GZR and EBR on Day 1 of Periods 1 and 2, and on Day 5 of Period 3. Results Coadministration of FAM 10 and 2 hours prior to FDC of GZR/EBR did not have a clinically relevant effect on SD GZR AUC0-∞, Cmax, and C24, with geometric mean ratios (GMRs) [90% confidence intervals (CIs)] of 1.10 [0.95, 1.28, 0.89 [0.71, 1.11], and 1.12 [0.97, 1.30], respectively.FAM also did not have a clinically relevant effect on EBR AUC0-∞, Cmax, and C24, with GMRs [90% CIs] of 1.05 [0.92, 1.19], 1.11 [0.98, 1.26], and 1.03 [0.91, 1.17], respectively.Similarly, coadministration of PAN with GZR/EBR FDC did not have a clinically relevant effect on SD GZR AUC0-∞, Cmax, and C24, with GMRs [90% CIs] of 1.12 [0.96, 1.30], 1.10 [0.89, 1.37], and 1.17 [1.02, 1.34], respectively.PAN also did not have a clinically relevant effect on EBR AUC0-∞, Cmax, and C24, with GMRs [90% CIs] of 1.05 [0.93, 1.18], 1.02 [0.92, 1.14], and 1.03 [0.92, 1.17], respectively.Conclusions Coadministration of GZR/EBR FDC with FAM or PAN had no clinically relevant effect on the PK of GZR or EBR.These results demonstrate that acid-reducing agents, such as H2-receptor antagonist and proton-pump inhibitors, may be coadministered with the GZR/EBR FDC in HCV-infected patients without restriction.