tbuckley/cabot-search huggingface dataset:
Notes and news
Authors: Mrs Mckewan
Journal: Annals of the Rheumatic Diseases (1990)

Magnetic resonance imagerA new Philip's Gyroscan T5 magnetic resonance imager is currently being installed at the King Edward VII Hospital at Midhurst, West Sussex, United Kingdom, at a cost of £1 million.This is one of only five of a new generation of scanners shortly to become operational-in the world and is the first one for the United Kingdom.It is hoped that this will be available to patients from the south of England.The new specially designed magnet has just been installed (figure).This new generation of scanner should help advance the use of MRI in investigation of disease and of course it allows both bone and soft tissues to be viewed simultaneously.
Abstract 1757: The effect of Zc3h8 expression levels on sensitivity to DNA damage and repair in mouse mammary cells
Authors: Spencer Li, John A. Schmidt, Janice E. Knepper
Journal: Cancer Research (2019)

Abstract Localized in PML nuclear bodies, the fetal liver zinc finger protein (Fliz), or ZC3H8, has been shown to increase cell proliferation, migration, and tumorigenesis in mouse mammary cell lines. While the exact function of ZC3H8 is unclear, PML nuclear bodies are critical centers for genome maintenance. Previous studies have suggested that these nuclear bodies act as deposits of sequestered DNA damage response proteins including SUMO-1, TP53, and BRCA-1. In addition to their localization to PML nuclear bodies, the phosphorylation of ZC3H8 by CK2 leads to dispersion of PML nuclear foci. For these reasons, we speculated that increased expression of Zc3h8, leading to greater protein availability, is involved in the suppression of DNA repair. This in return would increase genome instability and cancer cell aggression. This study uses the single cell comet assay to measure DNA damage repair following treatment with the topoisomerase inhibitor and chemotherapy drug etoposide. Two mouse mammary tumor cells lines, cV1A 01-51 and cV1A 03-31 were transfected to drive an shRNA targeting ZC3H8 (Flizout). In addition, the cV1A 03-31 Flizout line was rescued with a Zc3h8 construct with altered base coding to make transcribed products immune to shRNA targeting (SynFliz). We have also developed a constitutively charged cV1A 03-31 T32E mutant and a non-phosphorylatable T32A mutant. The nontumorigenic Comma1-D cell line was transfected with a vector to increase Zc3h8 expression. Ability to repair after etoposide treatment in these mutants was compared to controls carrying endogenous levels of Zc3h8. Etoposide leads to double strand breaks in the DNA during replication, and all cell lines were sensitive to etoposide and able to undergo repair. For the cV1A 01-51 lines, the control and Flizout mutants had a nonsignificant difference in post-repair comet length (p = 0.06) but a significant difference in tail moment (p = 0.003). Between the control and the mutants, the difference in overall comet length was 4.7%, and the difference in tail moment was 15.8%, with cells expressing higher levels of Zc3h8 being less adept in carrying out repair of double strand DNA breaks. This suggests an inverse relationship between Zc3h8 expression and DNA damage repair. This may indicate that evaluating Zc3h8 expression could be considered for determining the ability of tumor cells to respond to chemotherapy agents. Furthermore, altering its expression may be a novel approach for cancer treatment. Citation Format: Spencer Li, John A. Schmidt, Janice E. Knepper. The effect of Zc3h8 expression levels on sensitivity to DNA damage and repair in mouse mammary cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1757.
Rationing.
Authors: R. Hoffenberg
Journal: BMJ (1992)

Because we receive many more letters than we can publish we may shorten those we do print, particularly when we receive several on the same subject.Rationing specific services places clinicians in an extra-treatments is used alone to define health needs and ordinarily difficult position.Which patients set priorities they will be wrong.SIR,-Richard Smith's editorial on rationing im-should they select for their annual quota of coron-The call to follow Oregon and make rationing plies that I expressed paternalistic, indeed un-atv bypass operations?Should they reserve judg-decisions explicit and rational is therefore only part democratic, views in my Harveian oration.I ment on a particular patient in case a more of the solution.2The general public would have should like to try to explain myself.deserving one comes along to take up the last quota some involvement, but what is crucial is that any Like others with whom I've debated the issue place?Such decisions are being made today by universal system must try to allow for variation in Smith fails to distinguish between rationing and individual doctors dealing with individual patients, individual perceptions of need because individual determining priorities.In determining priorities, I most starkly by those with tight budgets.It is this people will place different values on each disability agree, everyone should be involved-doctors, sort of rationing that I would prefer to see implicit or condition.This flexibility is potentially lost nurses, other health professionals, managers, and rather than explicit, not through a belief in medical when clinicians are no longer responsible for the general public-and I made this point in my imperialism or paternalism but through a concern rationing.Oration.This is what happened in Oregon.As about the anguish that patients and their relatives Health authorities must accept that there is no
BOOK REVIEWS
Authors: A. ANDERSON
Journal: JNCI Journal of the National Cancer Institute (1990)

Journal Article BOOK REVIEWS Get access Enhancing the Role of Cancer Nursing . Carol Reed Ash , Jean F. Jenkins , eds. New York : Raven Press , 1989 , 320 pp. $46. ANITA ANDERSON ANITA ANDERSON Oncology Section/Radiology Service Veterans Administration Medical Center50 Irving St. N.W. Washington, DC 20422 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 82, Issue 9, 2 May 1990, Pages 789–790, https://doi.org/10.1093/jnci/82.9.789-a Published: 02 May 1990
Collagen Diseases
Authors: F. D. Hart
Journal: Annals of the Rheumatic Diseases (1956)

Continental treatment differs in certain respects from British practice, and more emphasis, for instance, is placed on spas.Also the patient abroad seems to associate radio-activity, in some vague manner, with the treatment of rheumatism-a habit of thought which is not discouraged.In fact, it may be said that, if dreams are the product of experience in the waking hours, the reviewer of continental medical literature is likely to have his slumbers disturbed by visions of petrol-pumps labelled "Fill up here with Thorium-X" and high voltage machines advertising "Emanations without Examina- tions"; in Great Britain, on the other hand, the public is becoming radiation-conscious, experts are questioning the desirability of certain diagnostic-radiology pro- cedures, and there is even heart-searching over the possibility that a proportion of cases of ankylosing spondylitis treated by deep x-rays may develop leukaemia in later years.The authors have provided an adequate alphabetical index but have deliberately curtailed the bibliography and quoted French references wherever possible; this measure of economy may be not unconnected with the cost of publication in France which, to judge by the price of the volume, is considerably higher than in England.
Radon Exposure Assessment—Connecticut
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Convalescent plasma in the management of moderate covid-19 in adults in India: open label phase II multicentre randomised controlled trial (PLACID Trial)
Journal: BMJ (2020)

the citation for reference 28 should appear at the end of the first paragraph of the strengths and limitations section of the discussion: "Although this approach could have affected comparability across study sites, we believe this lends the trial more generalisability, approximates real world scenarios more closely, and in the methodological spectrum of clinical trials, shifts it towards pragmatic trials.
Disseminated North American blastomycosis. Occurrence with clinical manifestations of adrenal insufficiency
Authors: D. E. Eberle
Journal: JAMA (1977)

Adrenal involvement in cases of disseminated North American blastomycosis occurs frequently, but clinically substantive adrenal insufficiency is rare. An unusual case of disseminated blastomycosis with clinical manifestations of adrenal insufficiency was found. One should be alert to the symptoms of adrenal insufficiency that may develop in patients with disseminated mycoses. (<i>JAMA</i>238:2629-2630, 1977)
THE BEDELLUS OF DELFT
Journal: JAMA (1961)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bronchography
Authors: J. C. Chugh
Journal: BMJ (1950)

<b>Objective</b> To determine the effects of low dose aspirin on cognitive function in middle aged to elderly men and women at moderately increased cardiovascular risk. <b>Design</b> Randomised double blind placebo controlled trial. <b>Setting</b> Central Scotland. <b>Participants</b> 3350 men and women aged over 50 participating in the aspirin for asymptomatic atherosclerosis trial. <b>Intervention</b> Low dose aspirin (100 mg daily) or placebo for five years. <b>Main outcome measures</b> Tests of memory, executive function, non-verbal reasoning, mental flexibility, and information processing five years after randomisation, with scores used to create a summary cognitive score (general factor). <b>Results</b> At baseline, mean vocabulary scores (an indicator of previous cognitive ability) were similar in the aspirin (30.9, SD 4.7) and placebo (31.1, SD 4.7) groups. In the primary intention to treat analysis, there was no significant difference at follow-up between the groups in the proportion achieving over the median general factor cognitive score (32.7% and 34.8% respectively, odds ratio 0.91, 95% confidence interval 0.79 to 1.05, P=0.20) or in mean scores on the individual cognitive tests. There were also no significant differences in change in cognitive ability over the five years in a subset of 504 who underwent detailed cognitive testing at baseline. <b>Conclusion</b> Low dose aspirin does not affect cognitive function in middle aged to elderly people at increased cardiovascular risk. <b>Trial registration</b> ISRCTN 66587262.
Unpasteurized Milk
Authors: Morris E. Potter
Journal: JAMA (1984)

Meaningful differences in nutritional value between pasteurized and unpasteurized milk have not been demonstrated, and other purported benefits of raw milk consumption have not been substantiated. Conversely, the role of unpasteurized dairy products in the transmission of infectious diseases has been established repeatedly. To effectively counsel patients attracted by the health claims made for raw milk, practicing physicians must understand both the rationale used by proponents of raw milk and the magnitude of the risk involved in drinking raw milk. (<i>JAMA</i>1984;252:2050-2054)
THE CRIMINAL CLASS AND THE SO-CALLED CRIMINAL TYPE
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 648: Effects of bazedoxifene and lapatinib in the prevention of estrogen receptor positive (ER+) and negative (ER-) mammary cancers
Authors: Clinton J. Grubbs, Altaf Mohammed, Shizuko Sei, Robert H. Shoemaker
Journal: Cancer Research (2019)

Abstract Bazedoxifene is a third-generation selective estrogen receptor modulator (SERM) that has been clinically approved in Europe for the prevention and treatment of postmenopausal osteoporosis. Our research previously showed that this agent (at a dose of 5 mg/kg diet) would decrease ER+ mammary cancers in rats by 73%. Lapatinib, an epidermal growth factor receptor (EGFR) inhibitor, is commonly used to treat patients with HER2+ breast cancer. We have also shown that the compound inhibits the development of ER+ mammary cancers in rats and ER- mammary cancers in mice at a dose of 75 mg/kg BW/day. The present studies were done to determine if lower doses and different treatment regimens designed to reduce possible toxicity would also be effective in preventing mammary cancers. Bazeodxifene was added directly to the diet (Teklad, 4% fat), while lapatinib was given by oral gavage. When evaluated in rats receiving methylnitrosourea (MNU), lapatinib given daily at doses of 75, 50 and 25 mg/kg BW/day reduced mammary cancer multiplicity by 93, 84 and 67%, respectively. Equivalent doses given 1x/week caused reductions of 87, 56, and 40%. When lapatinib was given to dimethylbenzanthracene (DMBA) treated MMTV/Neu mice at dose levels of 250, 125, and 63 mg/kg BW, 5x/week, mammary cancer multiplicity was reduced by 89, 60 and 80%, respectively. When equivalent doses were given 1x/week, the number of cancers were reduced by 82, 61, and 70%. Bazedoxifene given at 5.0 and 2.5 mg/kg diet to female MMTV/Neu mice also receiving DMBA caused reduction of mammary cancers by 73 and 51%. In a biomarker study lasting two weeks, bazedoxifene at the 5.0 mg/kg BW/day dose decreased the proliferation rate of normal mammary epithelial cells in MMTV/Neu mice by 60%. Additional studies to determine why this SERM is having a preventive effect against ER- mammary cancers are warranted. Studies to evaluate the efficacy of the combination of low doses of bazedoxifene and lapatinib in prevention of ER+ and ER- mammary cancers are in progress and will be presented. Supported by the NCI contract number HHSN261201500036I, Task Order HHSN26100005. Citation Format: Clinton J. Grubbs, Altaf Mohammed, Shizuko Sei, Robert H. Shoemaker. Effects of bazedoxifene and lapatinib in the prevention of estrogen receptor positive (ER+) and negative (ER-) mammary cancers [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 648.
Accumulation and persistence of hepatitis B virus core gene deletion mutants in renal transplant patients are associated with end-stage liver disease
Authors: S Günther
Journal: Hepatology (1996)

In renal transplant recipients, chronic hepatitis B virus (HBV) infection often leads to cirrhosis and liver failure. In this study, we investigated whether or not in these patients viral variants would emerge despite immunosuppression, and whether they are associated with a specific course of liver disease. In a population of 552 renal transplant recipients hepatitis B 24 surface antigen (HBsAg)-positive patients were available for a 2-year follow-up. By polymerase chain reaction (PCR) and DNA sequencing, HBV genomes with deletions in the middle of the core gene (C-gene) were found in 9 out of the 24 patients. Seven of the 9 patients (group I) showed either persistent or increasing amounts of these variants; all patients had cirrhosis, and 5 died of end-stage liver disease. The viral variants emerged at least 1 year before liver failure. In 2 out of the 9 patients, the core deletion variants disappeared, and no further deterioration of the liver function was observed thereafter. In the remaining 15 patients (group II) without deletion mutants detected at any time, only 3 had cirrhosis (P < .001, group I vs. II), and none died (P < .001). Between both groups, there were no statistically significant differences in the other relevant variables that were examined. These results indicate that HBV C-gene deletion mutants can accumulate in long-term immunosuppressed patients, and that their persistence is associated with progressive liver disease. The accumulation of these variants may be caused by the development of cirrhosis or could be involved in hepatopathogenesis.
Panniculus-Pannus
Authors: C. Ray Cress
Journal: JAMA (1973)

<h3>To the Editor.—</h3> In their article, "Massive Abdominal Panniculectomy" (225:408, 1973), Meyerowitz et al describe the excision of what they call a<i>pannus</i>. Since, it would seem to me,<i>panniculectomy</i>would indicate the removal of a panniculus rather than a pannus, I consulted the 24th edition of<i>Dorland's Illustrated Medical Dictionary</i>, and discovered the definition of<i>pannus</i>to be: "1. Superficial vascularization of the cornea with infiltration of granulation tissue. 2. An inflammatory exudate overlying the lining layer of synovial cells on the inside of a joint...." The 38.5-kg mass hanging from the ceiling in the illustration seems quite large for a lesion of either an eye or the inside of a joint. It appears that what was removed was not a<i>pannus</i>, but a<i>panniculus</i>, or, more specifically, a<i>panniculus adiposus</i>, which is defined in<i>Dorland's</i>as "those parts of the subcutaneous tissue which contain especially large amounts of
Separation of periportal and perivenous rat hepatocytes by fluorescence-activated cell sorting: Confirmation with colloidal gold as an exogenous marker
Authors: I Braakman
Journal: Hepatology (1991)

Periportal and perivenous hepatocytes are known to display various functional differences. In this study we present a new method to separate periportal and perivenous cells: after selectively loading zone 1 or zone 3 with the fluorescent label acridine orange in an antegrade or retrograde perfusion, respectively, we separated the isolated hepatocytes on a fluorescence-activated cell sorter. The common way to check on proper separation is to estimate activities of enzymes known to exhibit a heterogeneous acinar distribution. Using enzyme histochemistry, however, we found that already on short collagenase perfusion, some enzymes displayed a more shallow gradient than in vivo, making enzyme activities less suitable as zonal markers. We therefore used colloidal gold granules (17 nm) injected intravenously (2.5 mg) into the rat 2 to 3 hr before cell isolation. The gold is taken up predominantly by perivenous hepatocytes, probably because of the efficient removal of gold granules in zone 1 by competing Kupffer cells. We compared acridine orange fluorescence, presence of gold particles and activities of six marker enzymes, three biochemically and three histochemically determined. Acridine orange and gold both pointed to a high enrichment of the fractions, whereas most enzyme activities were more randomly distributed among the cells as a result of the isolation procedure. Our separation procedure yielded fractions highly enriched in either viable periportal or perivenous cells, both from one liver. The use of colloidal gold as a marker to monitor separation is a valuable alternative to the more risky estimation of enzyme activities. (HEPATOLOGY 1991;13:73–82).