tbuckley/cabot-search huggingface dataset:
Manuscript review from a statistician's perspective
Authors: N. Vaisrub
Journal: JAMA (1985)

People often ask me to define the function of a statistical review within the overall manuscript peer review process. Specifically, they are most curious about the contribution of the statistician in determining the publication fate of scientific reports. What follows is not an archetypal model congruent with some universal editorial philosophy, but rather my personal conviction as a long-term statistical reviewer for<i>JAMA</i>about the processes involved in statistical review, as well as the rationale underscoring decisions to accept or reject submitted papers. In a<i>JAMA</i>editorial entitled "A Pillar of Medicine," it was pointed out that "the biostatistician is not a worrisome censor, but a valuable ally," and that "biostatistics, far from being an unrelated mathematical science, is a discipline essential to modern medicine—a pillar in its edifice."<sup>1</sup>Along the same lines, we can think of a scientific study as an edifice of hypotheses built on the foundation
Workplace Partnership Boosts Screening for Colorectal Cancer
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract A08: Extensive subclonal mutations in human colorectal cancers detected by Duplex Sequencing
Authors: Edward John Paul Fox, Michael W. Schmitt, Kate S. Reid-Bayliss, Robert A. Beckman, Lawrence A. Loeb
Journal: Cancer Research (2017)

Abstract The accumulation of somatic mutations is a defining hallmark of cancer. The genomes of solid tumors contain thousands of mutations that are present in most or all of the malignant cells in that tumor. In addition to these clonal mutations, subclonal mutations, those occurring only in a fraction of malignant cells, likely contribute to the phenotypic and morphologic heterogeneity of cancer cells within a tumor. The extent of subclonal mutations in cancer, however, has been difficult to quantify, as the high error rate of next-generation sequencing precludes reliable detection of mutations present in fewer than 5% of cells. Here, we apply the highly accurate Duplex Sequencing methodology to quantify the extent of subclonal mutations in colorectal cancer (CRC) and paired normal mucosa. By sequencing known CRC driver and non-driver genes, we find that colorectal cancers without known DNA repair deficits harbor an extensive complement of subclonal mutations, in addition to the large number of clonal mutations previously identified. We show that normal colonic mucosa also accumulates substantial numbers of subclonal mutations in an age-dependent manner. The frequency of tumor-associated subclonal mutations, however, does not correlate with age, and has a spectrum distinct from that seen in normal tissue, indicating different mechanisms of mutation accumulation are operative in normal and tumor tissue. The frequency of tumor cells harboring unique subclonal mutations is so high that it is likely that every possible neutral somatic point mutation is present by the time a tumor is clinically detectable. We propose that these subclonal mutations likely accumulate in a series of punctuated bursts, making it highly likely that resistant subclones will emerge during chemotherapy. Citation Format: Edward John Paul Fox, Michael W. Schmitt, Kate S. Reid-Bayliss, Robert A. Beckman, Lawrence A. Loeb. Extensive subclonal mutations in human colorectal cancers detected by Duplex Sequencing. [abstract]. In: Proceedings of the AACR Special Conference on Colorectal Cancer: From Initiation to Outcomes; 2016 Sep 17-20; Tampa, FL. Philadelphia (PA): AACR; Cancer Res 2017;77(3 Suppl):Abstract nr A08.
CLIN-RADIOLOGY
Authors: Y. J. Choi, P. Gabikian, F. Zhu, D. E. Appelbaum, R. L. Wollmann, R. V. Lukas, L. W. Xu, R. P. Thomas, R. M. Lober, S. Nagpal, G. Li, J. F. Megyesi, D. Macdonald, N. Chaudhary, A. S. Berghoff, T. Spanberger, M. Magerle, C. Dinhof, A. Woehrer, M. Hackl, P. Birner, G. Widhalm, C. Marosi, D. Prayer, M. Preusser, D. O. Kamson, C. Juhasz, A. Buth, W. J. Kupsky, O. Muzik, N. L. Robinette, G. R. Barger, S. Mittal, M. Kinoshita, R. Hirayama, Y. Chiba, N. Kagawa, M. Nonaka, Y. Kanemura, H. Kishima, S. Nakajima, J. Hatazawa, N. Hashimoto, T. Yoshimine, E. H. Kim, S. H. Kim, M. Nowosielski, M. Hutterer, D. Putzer, S. Iglseder, M. Seiz, A. H. Jacobs, G. Gobel, G. Stockhammer, M. Hutterer, M. Nowosielski, D. Putzer, S. Iglseder, M. Seiz, A. H. Jacobs, G. Gobel, G. Stockhammer, C. Juhasz, A. Buth, D. O. Kamson, W. J. Kupsky, G. R. Barger, S. Mittal, L. Zach, D. Guez, D. Last, D. Daniels, Y. Grober, O. Nissim, C. Hoffman, D. Nass, R. Spiegelmann, Z. R. Cohen, Y. Mardor, S. Mittal, A. Buth, W. J. Kupsky, D. O. Kamson, G. R. Barger, C. Juhasz, S. Perreault, R. M. Lober, G. H. Zhang, L. Hershon, J.-C. Decarie, K. Yeom, H. Vogel, S. Partap, A.-S. Carret, P. G. Fisher, R. R. Colen, T. Changlai, P. Sathyan, D. Gutman, P. Zinn, R. R. Colen, A. Kovacs, P. Zinn, F. Jolesz, R. R. Colen, P. Zinn, A. Asthagiri, R. Vasquez, J. Butman, T. Wu, K. Morgan, C. Brewer, K. King, C. Zalewski, H. Jeffrey Kim, R. Lonser, H. Akbari, X. Da, L. Macyszyn, R. Verma, R. L. Wolf, M. Bilello, E. R. Melhem, D. M. O'Rourke, C. Davatzikos, X. Liu, A. B. Madhankumar, P. A. Miller, K. A. Duck, S. Hafenstein, E. Rizk, J. M. Sheehan, J. R. Connor, Q. X. Yang, S. J. Fouke, K. Weinberger, M. Kelsey, S. Cholleti, D. Politte, D. Marcus, A. Boyd, B. Keogh, T. Benzinger, M. Milchenko, L. Kim, F. Prior, L. M. Kim, P. Commean, A. Boyd, M. Milchenko, D. Politte, M. Chicoine, K. Rich, T. Benzinger, D. Marcus, S. Jost, G. Fatterpekar, E. Raz, E. Knopp, M. Gruber, E. Parker, J. Golfinos, D. Zagzag, E. Parker, G. Fatterpekar, E. Raz, A. Narayana, G. Johnson, D. Placantonakis, D. Zagzag, Q. Wen, E. Essock-Burns, Y. Li, S. Chang, S. J. Nelson, Y. Li, P. Larson, A. Chen, J. M. Lupo, D. Kelley, S. Chang, S. J. Nelson, Y. Li, J. M. Lupo, R. Parvataneni, K. Lamborn, S. Cha, S. Chang, S. J. Nelson, L. E. Jalbert, A. Elkhaled, J. J. Phillips, C. Williams, S. Cha, M. S. Berger, S. M. Chang, S. J. Nelson, D. M. Damek, D. E. Ney, M. T. Borges, W. Colantoni, R. Bert, R. Huang, C. Chen, S. Mukundan, P. Wen, A. Norden, J. B. Andre, H. Schmiedeskamp, R. P. Thomas, A. Feroze, S. Nagpal, G. Zaharchuk, M. Straka, L. Recht, R. Bammer, J. Rockhill, M. Mrugala, J. Fink, R. Rostomily, J. Link, M. Muzi, J. Eary, K. Krohn, S. Perreault, R. M. Lober, S. Partap, A.-S. Carret, F. G. Fisher, B. M. Ellingson, W. B. Pope, J. L. Boxerman, R. J. Harris, A. Lai, P. L. Nghiemphu, S. Jeyapalan, H. Safran, C. A. Kruse, L. M. Liau, T. F. Cloughesy, R. J. Harris, T. F. Cloughesy, A. Lai, P. L. Nghiemphu, W. B. Pope, B. M. Ellingson, A. Elkhaled, J. Phillips, S. M. Chang, S. Cha, S. J. Nelson
Journal: Neuro-Oncology (2012)
Anti-AIDS agents show varying early results in vitro and in vivo
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
DNA VACCINES
Authors: John J. Donnelly, Jeffrey B. Ulmer, John W. Shiver, Margaret A. Liu
Journal: Annual Review of Immunology (1997)

▪ Abstract Observations in the early 1990s that plasmid DNA could directly transfect animal cells in vivo sparked exploration of the use of DNA plasmids to induce immune responses by direct injection into animals of DNA encoding antigenic proteins. This method, termed DNA immunization, now has been used to elicit protective antibody and cell-mediated immune responses in a wide variety of preclinical animal models for viral, bacterial, and parasitic diseases. DNA vaccination is particularly useful for the induction of cytotoxic T cells. This review summarizes current knowledge on the vectors, immune responses, immunological mechanisms, safety considerations, and potential for further application of this novel method of immunization.
P53- and mevalonate pathway–driven malignancies require Arf6 for metastasis and drug resistance
Authors: Ari Hashimoto, Tsukasa Oikawa, Shigeru Hashimoto, Hirokazu Sugino, Ayumu Yoshikawa, Yutaro Otsuka, Haruka Handa, Yasuhito Onodera, Jin-Min Nam, Chitose Oneyama, Masato Okada, Mitsunori Fukuda, Hisataka Sabe
Journal: The Journal of Experimental Medicine (2016)
THE THERAPY OF THE COOK COUNTY HOSPITAL
Authors: BERNARD FANTUS
Journal: JAMA (1934)

<h3>THERAPY OF ECZEMA (DERMATITIS)</h3> This disorder is a noncontagious exudative inflammation of the skin. <h3>THE CAUSE</h3> The cause is twofold in all cases of true eczema: an irritant (exciting cause) and a special irritability (predisposition) of the skin. Without the latter, one has to deal with simple acute dermatitis. Eczema is always a chronic disease, with, however, a tendency to acute exacerbations. <h3>Exciting Causes.—</h3> These must always be looked for and eliminated when discovered. Several of these may act simultaneously. They may be: Chemical: Occupational poisons, as acid, alkalis, turpentine, formaldehyde, toilet articles such as strong soap, dyes (e. g., paraphenylenediamine, which is also used to stain furs), ingestion of medicines. Mechanical: Friction of opposing surfaces, woolen underwear, scratching (as on account of animal parasites), pressure. Thermal: Heat or cold. Actinic: The sun's rays. Allergens: For methods of discovery see "Allergy." Micro-Organisms: Though not perhaps a primary cause, these may
Reply
Authors: Elon H.C. van Dijk, Sascha Fauser, Myrte B. Breukink, Rocio Blanco-Garavito, Jan E.E. Keunen, Joannes M.M. Groenewoud, Petrus J.H. Peters, Greet Dijkman, Eric H. Souied, Robert E. MacLaren, Giuseppe Querques, Susan M. Downes, Carel B. Hoyng, Camiel J.F. Boon
Journal: Ophthalmology (2018)
Prescriber Profiling
Authors: Stephen E. Pratt
Journal: Annals of Internal Medicine (2008)

Letters1 January 2008Prescriber ProfilingStephen E. Pratt, MDStephen E. Pratt, MDFrom Oak Tree Internal Medicine, San Ramon, CA 94583.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-148-1-200801010-00013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I agree with Grande's sentiment (1), but I find the line of reasoning to be something of a non sequitur.Grande is advocating that physicians discontinue participation in pharmaceutical market research and that the sale of physician prescribing data should end. This would be in order to “roll back the influences of commercial marketing practices on clinical decisions.”Whereas these actions may be desirable for other reasons, neither would address the primary issue of the influence of commercial promotion on prescriber decision making. We could enact these changes tomorrow, and drug manufacturers would continue to advertise their ...Reference1. Grande D. Prescriber profiling: time to call it quits [Editorial]. Ann Intern Med. 2007;146:751-2. [PMID: 17502637] LinkGoogle Scholar Author, Article, and Disclosure InformationAuthors: Stephen E. Pratt, MDAffiliations: From Oak Tree Internal Medicine, San Ramon, CA 94583.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoPharmaceutical Marketing Research and the Prescribing Physician Jeremy A. Greene Prescriber Profiling: Time to Call It Quits David Grande Prescriber Profiling Stephen M. Kirk Prescriber Profiling Adriane Fugh-Berman Prescriber Profiling Alexander C. Tsai Metrics 1 January 2008Volume 148, Issue 1Page: 81-82KeywordsConflicts of interestDecision makingDrug informationDrug regulationDrug research and developmentDrugsMedical educationReasoning ePublished: 1 January 2008 Issue Published: 1 January 2008 Copyright & PermissionsCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Aortic Aneurysms
Authors: John L. Zeller, Alison E. Burke, Richard M. Glass
Journal: JAMA (2009)

Aortic AneurysmsT he aorta is the body' s largest artery and carries oxygen-rich blood from the heart to the rest of the body.The wall of the aorta is very elastic and can normally stretch and then shrink back as needed to adapt to blood flow.However, some medical conditions can weaken the arterial wall.These factors, along with the wear and tear that naturally occurs with aging, can result in a weak aortic wall that may stretch and bulge outwards.An aortic aneurysm is a stretched and bulging section in the wall of the aorta.A bulging or enlarged vessel is weakened and can burst or rupture, resulting in life-threatening bleeding.This condition is the 10th leading cause of death in men 65 to 74 years of age in the United States.
Age trends of lung cancer stage at diagnosis. Implications for lung cancer screening in the elderly
Authors: M. A. O'Rourke
Journal: JAMA (1987)

Lung cancer increases in incidence with increasing age and is the leading cause of cancer death in the United States. While mass screening for lung cancer is not indicated, selective screening of high-risk target groups may be beneficial. We tested the hypothesis that lung cancer is initially seen at a less advanced stage with increasing age using incidence cases (N = 22874) from the Centralized Cancer Patient Data System. The percent of lung cancer patients with local stage disease increased from 15.3% of those aged 54 years or younger, to 19.2% of those aged 55 to 64 years, to 21.9% of those aged 65 to 74 years, and to 25.4% of those aged 75 years or older. The percent with distant stage decreased from 48.7%, to 44.5%, to 40.3%, and to 36.7% for the same age groups, respectively. These age-stage trends persisted in subgroup analysis by sex, race, and histological subtype. Furthermore, analysis of 6332 patients who underwent surgical staging showed a greater likelihood of local stage disease with increasing age. Thus, compared with the young, the group aged 65 years or older is at a greater risk for lung cancer and has a higher proportion of lung cancer initially seen at local stage. The efficacy of selective screening for lung cancer in this target group warrants additional study. (<i>JAMA</i>1987;258:921-926)
New Year, 1973
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Long term treatment with salbutamol and salmeterol
Authors: Simon Hart
Journal: Thorax (1999)

Inhaled corticosteroids in COPDThe importance of presenting absolute cell numbers when counting cells in biological samples is illustrated by the potentially misleading interpretation of data in the paper by Marco Confalonieri and colleagues. 1 The authors concluded that, in addition to reduced sputum neutrophilia, the number of sputum macrophages increased significantly following treatment with inhaled beclomethasone dipropionate in patients with COPD.However, the observed increase in the proportion of sputum macrophages from 19.6% before treatment to 35.8% following treatment is entirely attributable to the reduced number of sputum neutrophils.From the data presented in the paper, the absolute numbers of diVerent cells in the sputum can be calculated (table 1), revealing that the absolute sputum macrophage count was essentially unchanged following treatment.It is important that the absolute numbers of cells, and not simply their proportions, are presented when measuring diVerential cell counts in sputum or any other biological sample.
Tracking the cocaine epidemic. The Drug Abuse Warning Network
Authors: H. D. Kleber
Journal: JAMA (1991)

POLICYMAKING in the fight against drug abuse should be driven by accurate epidemiologic data. By providing information on patterns and consequences of use and demographics of users, such data can show trends over time and the effectiveness of existing strategies. None of the existing datasets are flawless, as might be expected for information on illegal activities in a variety of populations. Thus, absolute numbers are less important than what the indexes show when looked at as a whole over prolonged periods.
Mouse Skin Tumor Initiation-Promotion and Complete Carcinogenesis Bioassays: Mechanisms and Biological Activities of Emission Samples
Authors: S. Nesnow, L. L. Triplett, T. J. Slaga
Journal: Environmental Health Perspectives (1983)

Extracts of soots obtained from various sources were applied to the skin of mice in an effort to identify carcinogens in these mixtures and to link these materials to the etiology of human cancer. Samples of coal chimney soot, coke oven materials, industrial carbon black, oil shale soot, and gasoline vehicle exhaust materials have been examined by this method. The studies reported here have been constructed to compare the carcinogenic and tumorigenic potency of extracts from various particulate emissions: coke ovens, diesel and gasoline vehicles and a roofing tar pot. Automobile emission samples were obtained by collecting the diluted and cooled exhaust on Teflon-coated glass fiber filters. Coke oven and roofing tar samples were particulate emission samples collected by impaction and filtration. The organic components associated with each of the particles were extracted with dichloromethane and dermally applied to SENCAR mice. All agents were applied as tumor initiators by using a five-dose protocol. Selected extracts were also applied as complete carcinogens and as tumor promotors. Statistical analyses of the resulting tumor data were performed by using nonlinear Poisson and probit models. The results from these experiments provide a suitable data base for comparative potency estimation of complex mixtures.
Nursing homes and fax machines
Authors: E. G. Tangalos
Journal: JAMA (1990)

<h3>To the Editor.—</h3> The transmission of medical orders and medication changes from the physician's office to the nursing home has been a time-consuming process in the provision of health care for the elderly.<sup>1</sup>During the last year we implemented a program that uses facsimile (fax) machines to transmit physician orders to seven local nursing homes. We believe that this model has wide applicability for physicians with large nursing home practices.<sup>2</sup> <h3>Study.—</h3> During a 1-month trial, a rented fax machine was used to transmit signed physician orders to a 159-bed nursing home. Our goal during this trial period was to design and implement a model for transmission of orders and to determine if this model was time effective in terms of staff at both the nursing home and our clinic. Another factor we needed to consider was the overall cost of this model (<i>Newsweek</i>. April 24, 1989:60). We used
Medical consultation via communications satellite
Authors: R. S. Riggs
Journal: JAMA (1974)

A patient with lymphosarcoma was described via communications earth satellite to medical experts in Washington, DC from aboard the hospital ship SS<i>Hope</i>anchored in Maceió, Brazil. The experimental consultation employed a small, potentially mobile transmitter-receiver aboard the ship to exchange voice and teletype communication, to receive facsimiles of journal articles, and to send still video pictures of patients, x-ray films, and microscopic slides. Medical telecommunications via satellite can provide prompt, expert medical consultation to remote areas of the globe and can increase the effectiveness of medical personnel. (<i>JAMA</i>228:600-602, 1974)
Mitral Insufficiency Resulting from Rupture of Normal Chordae Tendineae
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal