tbuckley/cabot-search huggingface dataset:
A phase II, open-label, randomized study to evaluate the efficacy and safety of GS-5745 combined with nivolumab versus nivolumab alone in subjects with unresectable or recurrent gastric or gastroesophageal junction adenocarcinoma.
Authors: Manish A. Shah, Jean-Philippe Metges, Patrick Youngwhan Chun, Victoria Smith, Julia D. Maltzman, Zev A. Wainberg
Journal: Journal of Clinical Oncology (2017)

TPS4141 Background: GS-5745 is a monoclonal antibody that inhibits matrix metalloproteinase 9 (MMP9), an extracellular enzyme involved in matrix remodeling, tumor growth, and metastasis. Inhibiting MMP9 is expected to block paracrine signaling and metastasis and to alter the immune microenvironment within the tumor. Results from the ATTRACTION-2 Phase III trial showed the PD-1 inhibitor nivolumab significantly improved overall survival (OS), progression-free survival (PFS), and overall response rate (ORR) in patients with heavily pre-treated advanced gastric or gastroesophageal junction cancer. Preclinical studies indicate that selective inhibition of MMP9 can inhibit immune-suppressive myeloid cell polarization, regulatory T cell generation, desmoplasia, and the destruction of ligands for CXCR3 (a critical chemokine receptor that enables effector T cell trafficking). In combination with a checkpoint inhibitor, CD8+, CD4+ and CD44+ cytotoxic T cells are significantly increased in a checkpoint-refractory model, suggesting that MMP9 inhibition could relieve immune suppression. Methods: This phase 2, open-label, randomized study investigates the efficacy and safety of GS-5745 combined with nivolumab versus nivolumab alone in patients with unresectable or recurrent gastric or gastroesophageal adenocarcinoma. 120 patients will be randomized to either GS-5745 800mg IV + nivolumab 3mg/kg IV, or nivolumab alone. Treatment will be administered every 2 weeks and stratified by PD-L1 status. CT will be performed every 8 weeks to evaluate response. The primary endpoint of the study is ORR; secondary endpoints include PFS, OS, and occurrence of adverse events. Key inclusion criteria: metastatic or inoperable adenocarcinoma of the stomach or GEJ which has progressed after ≥1 prior systemic therapy, ECOG performance status ≤1, RECISTv1.1 measureable disease, archival tissue adequate for PD-L1 evaluation. Exploratory biomarkers correlated with study drug response will also be evaluated. Enrollment opened September 2016. Clinical trial information: NCT02864381.
Winter Solstice
Authors: Pamela Gross
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Scrofulous Diseases of the External Lymphatic Glands: Their Nature, Variety, and Treatment
Authors: P. C. Price
Journal: BMJ (1861)

ORIGINAL, COMMUNICATIONS.IBRITISH MEDICAL JOURiAL.and several whole black currants, besides the seeds of many others.This relieved him a good deal, he per- spired freely, and afterwards was able to take a little tea with bread and butter.In the evening lhe had another small motion, but the abdomen remained distended and 'k
Persistence of vacuolated RBCs after splenectomy in adults
Authors: B. A. Neilan
Journal: JAMA (1980)

Children undergoing splenectomy after trauma commonly have few vacuolated RBCs, suggesting a recurrence of splenic activity. We assayed RBCs with vacuoles in 17 adults who had splenectomies for trauma and 15 adults who underwent splenectomy for nontraumatic indications. Vacuolated cells averaged 29.0%±1.0% (SE) in adults having emergency splenectomies and 32.3%±2.0% in those having elective splenectomies. One adult who had a splenectomy for trauma had few RBCs with vacuoles, and a technetium Tc 99m sulfur colloid spleen scan showed one accessory spleen. These findings suggest that recurrence of splenic activity in adults, unlike in children, is an uncommon sequela of splenic rupture. (<i>JAMA</i>243:1741-1742, 1980)
Fibrositis
Authors: T. B. Sellors
Journal: BMJ (1948)

<h3>Abstract</h3> Adaptation constraints within crop species have resulted in limited genetic diversity in some breeding programs and/or areas where new crops have been introduced, <i>e.g.,</i> lentil <i>(Lens culinaris</i> Medik.) in North America. An improved understanding of the underlying genetics involved in phenology-related traits is valuable knowledge to aid breeders in overcoming limitations associated with unadapted germplasm and expanding their genetic diversity by introducing new, exotic material. We used a large, 18 site-year, multi-environment dataset, phenotyped for phenology-related traits across nine locations and over three years, along with accompanying latent variable phenotypes derived from a photothermal model and principal component analysis (PCA) of days from sowing to flower (DTF) data for a lentil diversity panel (324 accessions) which has also been genotyped with an exome capture array. Genomewide association studies (GWAS) on DTF across multiple environments helped confirm associations with known flowering time genes and identify new quantitative trait loci (QTL), which may contain previously unknown flowering time genes. Additionally, the use of latent variable phenotypes, which can incorporate environmental data such as temperature and photoperiod as both GWAS traits and as covariates, strengthened associations, revealed additional hidden associations, and alluded to potential roles of the associated QTL. Our approach can be replicated with other crop species, and the results from our GWAS serve as a resource for further exploration into the complex nature of phenology-related traits across the major growing environments for cultivated lentil.
Use of mefenamic acid in the treatment of primary dysmenorrhea
Authors: P. W. Budoff
Journal: JAMA (1979)

Mefenamic acid (Ponstel), 250 mg four times a day, and placebo were compared in a double-blind, crossover study conducted in 46 women with primary spasmodic dysmenorrhea. When compared with placebo, treatment with mefenamic acid resulted in significant decreases in the frequency and severity of the symptoms, and significantly reduced the need for additional analgesic medication. Mefenamic acid was well tolerated. No changes in clinical laboratory values were associated with its use. (<i>JAMA</i>241:2713-2716, 1979)
Severe Hypoproteinemia
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diagnosis of Diabetes.
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Journal of Urology, Baltimore
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Selected New Books
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue Access Provided by Korea University Medical Library JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account
Postcolonoscopy pancreatitis
Authors: Skand Shekhar, Seema Singh, Sanjay Gupta
Journal: Endoscopy (2014)

Colonoscopy is a therapeutic and diagnostic procedure with complications commonly including intestinal perforation, splenic injury, gastrointestinal bleeding, and cardiopulmonary complications. We report the case of a 25-year-old woman who developed acute pancreatitis following a diagnostic colonoscopy.
Patients' ratings of outpatient visits in different practice settings. Results from the Medical Outcomes Study
Authors: H. R. Rubin
Journal: JAMA (1993)

<h3>Objective.</h3> —To determine how patients in different kinds of practices—solo or single specialty (SOLO), multispecialty group (MSG), or health maintenance organizations (HMOs)—and with fee-for-service (FFS) or prepaid physician payment arrangements evaluate their medical care. <h3>Design.</h3> —Survey of adult outpatients after office visits, with sample weighted to represent population of patients visiting physicians in each practice type. <h3>Setting.</h3> —Offices of 367 internists, family practitioners, endocrinologiste, cardiologists, and nurse practitioners, in HMOs (prepaid only), MSGs (prepaid and FFS), and SOLO practices (prepaid and FFS). <h3>Patients.</h3> —Adults (N=17671) at start of the Medical Outcomes Study. <h3>Outcome Measures.</h3> —Overall rating of the visit (five choices from excellent to poor). A random half of the sample also rated the provider's technical skills, personal manner, and explanations of care as well as time spent during the visit, the appointment wait, the office wait, the convenience of the office location, and telephone access. <h3>Results.</h3> —Fifty-five percent of patients rated their visit overall as excellent, 32% very good, 11% good, and 2% fair or poor. Patients of SOLO practitioners were more likely (64%) to rate their visit excellent than MSG (48%) or HMO (49%) patients (<i>P</i>&lt;.001 ). Patients of SOLO practitioners rated all aspects of care better than HMO patients did, most markedly appointment waits (64% vs 40% excellent;<i>P</i>&lt;.0001) and telephone access (64% vs 33% excellent;<i>P</i>&lt;.0001). Within SOLO and MSG practices, FFS patients rated most specific aspects better than prepaid patients, but these differences were not statistically significant and were inconsistent across cities. Adjusting for patients' demographics, diagnoses and self-rated health did not change results. Physicians with visit ratings in the lowest 20% were nearly four times as likely to be left by patients within 6 months than physicians in the highest 20% (16.7% vs 4.6%;<i>P</i>&lt;.001). <h3>Conclusion.</h3> —Of the five practice type and payment method combinations, SOLO FFS patients rated their visits best and HMO patients worst. Whether FFS or prepaid, care was rated better in small than in large practices. Our study shows that a brief visit rating form can be used to compare practice settings and health plans, and that patient ratings predict what proportion of patients, on average, will leave their physicians in the next several months. (<i>JAMA</i>. 1993;270:835-840)
Adult Scurvy
Authors: James B. Reuler
Journal: JAMA (1985)

Scurvy is a disease that can mimic other more serious disorders such as deep vein thrombosis, vasculitis, and systemic bleeding disorders. Because the clinical features of scurvy are no longer well appreciated, scorbutic patients are often extensively evaluated for other disorders. Familiarity with the risk factors for and clinical manifestation of scurvy can facilitate earlier diagnosis. We report three patients who highlight the epidemiology, clinical features, and differential diagnosis of scurvy. (<i>JAMA</i>1985;253:805-807)
New Flexible Vascular Adhesive for Use in Cardiovascular Surgery
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Induction of Adrenal Suppression by Megestrol Acetate
Authors: S.H. Khoo
Journal: Annals of Internal Medicine (1996)

Letters15 March 1996Induction of Adrenal Suppression by Megestrol AcetateS.H. Khoo, MD, E.G.L. Wilkins, MD, and M. Abbott, MDS.H. Khoo, MDNorth Manchester General Hospital; Manchester M8 6RL; United KingdomSearch for more papers by this author, E.G.L. Wilkins, MDNorth Manchester General Hospital; Manchester M8 6RL; United KingdomSearch for more papers by this author, and M. Abbott, MDNorth Manchester General Hospital; Manchester M8 6RL; United KingdomSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-124-6-199603150-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Leinung and colleagues [1] recorded evidence of adrenal suppression by megestrol acetate. We have made similar observations in a study of cortisol function in 49 patients positive for human immunodeficiency virus (HIV) in Manchester, United Kingdom [2].We assessed cortisol responses to the short-stimulation cosyntrophin test in HIV-positive patients who were most vulnerable to adrenal insufficiency, that is, those with CD4 lymphocyte counts of 50 cells/mm3 or less. Forty-nine patients were recruited (42 men, 7 women; age range, 25 to 56 years; CD4 count range, 4 to 50 cells/mm3; median CD4 count, 16 cells/mm3). Plasma cortisol levels ...References1. Leinung MC, Liporace R, Miller CH. Induction of adrenal suppression by megestrol acetate in patients with AIDS. Ann Intern Med. 1995; 122:843-5. Google Scholar2. Abbott M, Khoo SH, Hammer M, Wilkins EG. Prevalence of cortisol deficiency in late HIV disease. J Infect. 1996; 31:1-4. Google Scholar3. Bayliss RI. Adrenal cortex. Clin Endocrinol Metab. 1980; 9:477-86. Google Scholar Author, Article, and Disclosure InformationAuthors: S.H. Khoo, MD; E.G.L. Wilkins, MD; M. Abbott, MDAffiliations: North Manchester General Hospital; Manchester M8 6RL; United Kingdom PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byA comparison of megestrol acetate, nandrolone decanoate and dietary counselling for HIV associated weight lossMegestrol Acetate: Promises and Pitfalls 15 March 1996Volume 124, Issue 6Page: 613KeywordsAIDSAntifungalsCortisolHIVIntramuscular injectionsLymphocytesObservational studiesOpiatesPatientsSteroid therapy ePublished: 15 August 2000 Issue Published: 15 March 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Error in Equation.
Journal: JAMA (1996)

Gordon H. Guyatt, MD; David L. Sackett, MD; John C. Sinclair, MD; Robert Hayward, MD; Deborah J. Cook, MD; Richard J. Cook, PhD; Eric Bass, MD, MPH; Hertzel Gerstein, MD, MSc; Brian Haynes, MD, MSc; Anne Holbrook, MD, PharmD, MSc; Roman Jaeschke, MD, MSc; Andreas Laupacls, MD, MSc; Virginia Moyer, MD, MPH; Mark Wilson, MD, MPH
The Croonian Lectures on Some Points in the Pathology and Treatment of Typhoid Fever
Authors: W. Cayley
Journal: BMJ (1880)

THE BRITISH EMECALt 0URNAL.685 obtained; in another case, there was greater tolerance of food, and more comfort after it, than with the use of simply diluted milk.It would be interesting, also, to have experience of the use of peptonised aliment in typhoid fever and in old age.The greater variety which can now be given to this form of food by the preparation of peptonised soups, jellies, and blanc-manges, will obviate the monotony sometimes ,complained of under the continuous use of peptonised milk-gruel.
EMULSIFYING BASES
Authors: J. SOULSBY
Journal: British Journal of Dermatology (1940)

Journal Article EMULSIFYING BASES Get access J. SOULSBY, Ph.C. J. SOULSBY, Ph.C. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 52, Issue 1, 1 January 1940, Pages 25–35, https://doi.org/10.1111/j.1365-2133.1940.tb09893.x Published: 01 January 1940
Hematopoietic stem cell markers are expressed by ductal plate and bile duct cells in developing human liver
Authors: K BLAKOLMER
Journal: Hepatology (1995)

The identification of ductal plate cells as likely progenitors for bile duct epithelium and hepatocytes and their possible reappearance as oval cells in the regenerating liver have generated much interest in their pluri-potential capacities. We have examined the distribution of three hematopoietic stem cell markers, c-kit, CD34, and CD33 in addition to laminin, the standard cytokera-tin markers CAM 5.2, CK 18, and CK 7 and the oval cell marker OV-6 in fetal liver during various stages of development. Hematopoietic stem cell markers were expressed in ductal plate cells in a pattern similar to the early cytokeratin markers CAM 5.2 and CK 18. Cells stained strongly for these early cytokeratin markers until 22 weeks. Thereafter, the expression of these markers decreased while positivity for CK 7 increased. Bile duct cells showed a distribution of hematopoietic and cytokeratin markers resembling that of ductal plate cells. Both ductal plate cells and bile duct cells expressed OV-6 strongly throughout development. This study showed similarity between hepatic and bile duct precursors and bone marrow stem cells. The comparable distribution of markers in bile duct epithelium and ductal plate cells may imply fewer transitional stages between ductal plate cells and bile duct epithelium than between the putative stem cells and hepatocytes.