tbuckley/cabot-search huggingface dataset:
PTU-160 Raised intraepithelial lymphocytes in the presence of normal small bowel mucosa: confirmation of coeliac disease in clinical practice
Authors: S Subramaniam, A Joshi, K Besherdas
Journal: Gut (2015)

<h3>Introduction</h3> Raised intraepithelial lymphocytes (IEL) (&gt;30–40 IEL/100 enterocytes) in small bowel (SB) mucosa is associated with coeliac disease (CD) when accompanied by distorted villous architecture. In addition to CD, there are other causes of raised IEL including NSAIDs, autoimmune conditions, tropical sprue, H pylori associated gastritis and intestinal lymphoma. It is recommended that patients who have raised IEL without distorted villous architecture (Marsh classification Stage 1 criteria) undergo further serological testing along with HLA DQ2 DQ8 genotyping to assist in the diagnosis of CD. The aim of the study was to determine the further assessment in clinical practice of patients with raised IELs in otherwise normal SB biopsies to confirm the diagnosis of CD. <h3>Method</h3> A single centre, retrospective analysis of patients with the histological finding of raised IELs on distal duodenal (D2) biopsies in a district general hospital was performed. A database of patients with raised IEL was obtained from the hospital histology database and data on the patients coeliac antibody result, symptoms, diagnosis and management was scrutinised using the electronic patient record system. <h3>Results</h3> 121 patients had raised IEL on D2 biopsy specimens. 58 of these patients had a confirmed diagnosis of CD with villous atrophy. The remainder (63) had raised IEL with preserved villous architecture. 48/63 patients were negative for coeliac antibodies, 1 was positive and 14/63 (22.2%) were not tested. 15/63 (23.8%) were initiated on a gluten free diet and of this, 4 did not report an improvement in their symptoms despite adherence. Only 2 patients had HLA DQ2/DQ8 testing to aid in the diagnosis of CD. A final diagnosis of CD was made in 11/63 (17.5%) patients meeting Marsh 1 criteria. 32/63 (50.8%) patients had a diagnosis of gastrooesophageal reflux disease (GORD) including 10 patients (15.9%) with H pylori associated gastritis. H pylori was not tested in 13/32 patients with GORD (40.6%). A third of patients (20/63 = 31.7%) with raised IEL and normal SB mucosa did not undergo any further specific investigation to elucidate the cause of the raised IELs. <h3>Conclusion</h3> There is marked variability in management of patients following the findings of raised IEL with normal SB mucosa. A fifth of patients did not have coeliac antibody tested and only 2 patients had HLA DQ2 DQ8 genotype assessment. Latent CD was diagnosed in almost a fifth (17.5%) of patients with raised IEL and preserved villi whilst GORD and H pylori gastritis were present in half of the patients with this finding. We recommend that all patients in whom raised IELs are identified have coeliac serology and HLA DQ2 DQ8 testing to exclude CD prior to entertaining other diagnoses in clinical practice. <h3>Disclosure of interest</h3> None Declared.
THE MEDICAL CRISIS IN FRANCE.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Science ponders whether HIV acts alone or has another microbe's aid
Authors: M. F. Goldsmith
Journal: JAMA (1990)

DEBATE has been rekindled over whether the human immunodeficiency virus (HIV) itself grows virulent enough in the body to cause acquired immunodeficiency syndrome (AIDS) and kill its host, or whether it has some help from another microbe. In San Francisco, at the Sixth International Conference on AIDS, Jay A. Levy, MD, presented new data on increasing virulence. Levy is professor of medicine at the University of California, San Francisco (UCSF), and discoverer—shortly after the Pasteur Institute's Luc Montagnier, MD, and the National Cancer Institute's Robert Gallo, MD—of the similar organism he named "AIDS-related virus." Levy and colleagues have found viral genetic changes that may help explain why HIV-positive people progress to AIDS. Their discoveries may also offer a new target for therapy. "Recognizing the diversity of HIV strains," Levy says, "the surprising observation was made that an HIV strain obtained from an individual with nonsymptomatic infection was different from the
Diagnostic accuracy of magnetic resonance elastography for the staging of fibrosis and diagnosis of steatohepatitis in patients with non-alcoholic fatty liver disease: a systematic review and meta-analysis
Authors: Ferenc Mozes, Hadi Zafarmand, Arjun Jayaswal, Emmanuel Selvaraj, Christina Levick, Naaventhan Palaniyappan, Chang-Hai Liu, Stefan Neubauer, Manuel Romero Gomez, Guruprasad Aithal, Quentin Anstee, Stephen Harrison, Patrick Bossuyt, Michael Pavlides
Journal: Journal of Hepatology (2020)
Cost-minimization comparison of infusion based FOLFIRI (5-fluorouracil and leucovorin) versus oral based XELIRI (capecitabine and irinotecan) in metastatic colorectal cancer (mCRC)
Authors: R. Baran, E. McKenna, Y. Patt, N. Ghali
Journal: Journal of Clinical Oncology (2004)

3762 Background: Capecitabine (Xeloda), an oral fluoropyrimidine, has been explored as an alternative to infusional 5-FU in irinotecan regimens, assuming capecitabine can clinically replace infusional 5-FU. This cost-minimization model compares the total cost of care for FOLFIRI versus XELIRI regimens in first line mCRC. Methods: Clinical response endpoints (objective response rates, time to tumor progression) and patient populations reported for FOLFIRI (Tournigand C. JCO 2004) and XELIRI (Patt YZ. ASCO 2003) are similar in published clinical trials, justifying the cost-minimization comparison method. Costs of drug acquisition and administration were projected over 24 weeks, corresponding to therapy in trials. Analysis included 2 week cycles of FOLFIRI and 3 week cycles of XELIRI. Costs of drugs, adverse events (AEs), reimbursement of services, and supplies were based on Dec 2003 Medicare fee schedules. Treatment costs for adverse events in each regimen were based on documented incidences and costs. Results: Drug acquisition plus administration costs for FOLFIRI totaled $38,301 versus $37,687 for XELIRI. Cost of drug only for FOLFIRI was $32,159 versus $36,728 for XELIRI. FOLFIRI incurred additional costs for pump maintenance, infusion, and line access. Treatment costs for AEs with FOLFIRI totaled $1,580 versus $502 with XELIRI Drivers of AE costs were anemia and febrile neutropenia which were more frequent with FOLFIRI. Total cost of care associated with FOLFIRI was $39,881 versus $38,189 for XELIRI, a reduction of 4.24%. Conclusions: XELIRI reduces costs versus FOLFIRI due to overall ease and safety of oral administration and less frequent and costly AEs. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Roche Labs Roche Labs
The fat boy goes poly-unsaturated.
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fitusiran, an Investigational RNAi Therapeutic Targeting Antithrombin for the Treatment of Hemophilia: Updated Results from a Phase 1 and Phase 1/2 Extension Study in Patients with Inhibitors
Authors: K John Pasi, Pencho Georgiev, Tim Mant, Toshko Lissitchkov, Michael Desmond Creagh, David Bevan, Steve Austin, Charles R Hay, Inga Hegemann, Rashid Kazmi, Pratima Chowdary, Margaret V. Ragni, Chang-Heok Soh, Akin Akinc, Angela M. Partisano, Benny Sorenson, Savita Rangarajan
Journal: Blood (2016)
TULAREMIA
Authors: EDWARD FRANCIS
Journal: JAMA (1925)

Tularemia occurs in nature as a very fatal bacteremia of various rodents (especially rabbits) and is due to<i>Bacterium tularense</i>; it is transmissible to man as an accidental infection by the bite of an infected blood-sucking insect or tick, or by the lodgment on his hands, of the blood or internal organs of an infected rodent, as in the case of market men, cooks, hunters or laboratory workers. Among the few diseases of man that have been discovered in the last fifteen years is tularemia. It is the only disease of man that has been elucidated from beginning to end by American investigators alone. These investigators have worked in widely separated states, and in most instances each made his first contribution while in ignorance of the work of the others. The first observations of each were characterized by the nature of the work for which he was especially trained; thus,
Books in Brief
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AFIP: pathology laboratory to the world
Authors: B. Merz
Journal: JAMA (1989)

THERE ARE 2700 BRAINS at the Armed Forces Institute of Pathology (AFIP). Seven hundred are engaged in running the institute; 2000 are sectioned and mounted. The 125 pathologists and their 575 staff associates at the Walter Reed-based facility are entrusted with the Yakovlev Collection, the world's largest collection of serially sectioned human brains. But that's only one facet of their job. They oversee 2 200 000 case reports that have accumulated since the institute was established; they account for 350 publications in the scientific literature annually; they handle 350 consultations each day; they spend 60 000 person-days a year training pathologists; and they administrate an annual budget of more than $35 million. If the Smithsonian Institution is the nation's attic, the AFIP may be considered its morgue. Its role as such dates to the inception of its antecedent, The Army Medical Museum, in 1862. That institution was born of a
Oliver-Sharpey Lectures ON THE NATURE OF FLUTTER AND FIBRILLATION OF THE AURICLE
Authors: T. Lewis
Journal: BMJ (1921)

59O AwitI 23, i92 IT AtYRICULARFIBRILLATIONo Tz MEIA ORIT1IWith regard to so-called physical exercises, postural scoliosis is due, not to muscular weakness, but to deficiency o£ the habitual subconscious state of reflex activity whici ilozmally maintains the upright attitude.The object of 'treatmeAt, therefore, is not; to.stren'gthen or develop (To be continued.)
Oncogene Activation in Spontaneous and Chemically Induced Rodent Tumors: Implications for Risk Analysis
Authors: Steven H. Reynolds, Shari J. Stowers, Rachel M. Patterson, Robert R. Maronpot, Marshall W. Anderson
Journal: Environmental Health Perspectives (1988)

The validity of rodent tumor end points in assessing the potential hazards of chemical exposure to humans is a somewhat controversial but very important issue since most chemicals are classified as potentially hazardous to humans on the basis of long-term carcinogenesis studies in rodents. The ability to distinguish between genotoxic, cytotoxic, or receptor-mediated promotion effects of chemical treatment would aid in the interpretation of rodent carcinogenesis data. Activated oncogenes in spontaneously occurring and chemically induced rodent tumors were examined and compared as one approach to determine the mechanism by which chemical treatment caused an increased incidence of rodent tumors. Different patterns of activated oncogenes were found not only in spontaneous versus chemically induced mouse liver tumors but also in a variety of spontaneous rat tumors versus chemically induced rat lung tumors. In the absence of cytotoxic effects, it could be argued that the chemicals in question activated protooncogenes by a direct genotoxic mechanism. These results provided a basis for the analysis of activated oncogenes in spontaneous and chemically induced rodent tumors to provide information at a molecular level to aid in the extrapolation of rodent carcinogenesis data to human risk assessment.
Incorrect Chemical Structure
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
NEW INSTRUMENTS.
Journal: JAMA (1890)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Patients' Rights
Authors: Joseph C. Rush
Journal: JAMA (1974)

<h3>To the Editor.—</h3> The recent statement (226:562, 1973) of Edwin J. Holman, Attorney from the Office of General Counsel of the AMA, regarded hard cases as making bad law. I am sure that this is true. His statement reflects the idea that medicine is allowed to do its own self-policing, providing that it reasonably acts in the public interest. The statement also carries with it the warning that if it does not, then society (since it makes the rules) may impose upon organized medicine more restrictive legislation in an attempt to guarantee the public interest. Because of government participation in medicine through Medicare, Medicaide, and possibly Health Maintenance Organization, as well as Physicians' Standards Review Organization, it appears to me that organized medicine should have a positive approach to a Health Care Delivery System retaining as much as possible those characteristics that individual physicians desire. But it must also police
Clonazepam: effective treatment for restless legs syndrome in uraemia
Authors: T. Feest, D. Read
Journal: BMJ (1982)

Orchidectomy alone for stage I testicular teratomaIt has been common practice in the United Kingdom to recommend abdominal lymph node irradiation after orchidectomy for malignant teratoma of the testis, even in the absence of demonstrable abdominal disease.We present the details of 21 men whose only treatment at the time of presentation was orchidectomy.Their subsequent survival and pattern of relapse were compared to a similar group of irradiated patients to determine the benefits of prophylactic irradiation. Patients, methods, and resultsAll patients were referred after radical orchidectomy.Clinical examination and chest radiography were the only staging procedures consistently adopted and no evidence of metastases was found.Twenty-one men seen between 1946 and 1973 received no further treatment at the time of referral.Histological specimens were reviewed at this hospital.Eighteen were malignant teratoma intermediate, two were malignant teratoma undifferentiated, and one was malignant teratoma trophoblastic.Between 1961 and 1970 100 men received postoperative lymph node irradiation.Thirty-three had malignant teratoma intermediate, 39 malignant teratoma undifferentiated, two malignant teratoma trophoblastic, two mixed teratoma and trophoblastic, and 24 mixed teratoma and seminoma.In more than two-thirds of the untreated patients radiotherapy was deferred because of recurring doubts about its efficacy.One patient was receiving peritoneal dialysis for unrelated chronic renal failure and another was severely mentally retarded.Two refused further treatment, and one was not referred until six months after orchidectomy.Fourteen patients remained alive and well.All deaths (7 of 21) occurred within two years of presentation and were due to metastatic disease.One patient died with uncontrolled para-aortic disease, six with widespread metastatic disease, and five with definite lung metastases.Analysis of deceased patients from the untreated group Time Case Age
Erratum: Gianturco-Z Stents in the Palliative Treatment of Malignant Esophageal Obstruction and Esophagotracheal Fistulas
Authors: C. Ell, A. May, E. G. Hahn
Journal: Endoscopy (1995)

Correction to: Gianturco-Z Stents in the Palliative Treatment of Malignant Esophageal Obstruction and Esophagotracheal FistulasEndoscopy 1995; 27(07): 495-500DOI: 10.1055/s-2007-1005754
<i>Salmonella</i>in Backyard Poultry
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Physiotherapy Technic. A Manual of Applied Physics.
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Corrigendum
Authors: Alastair Kerr, Kowalewski Cezary, Warsaw Lehmann, Joanna Narbutt, Lodz Schmid-Grendelmeier, David Fisher, F Hodi
Journal: British Journal of Dermatology (2009)

welcomes basic, translational, and clinical investigators from lab to clinic in all aspects of melanoma research and care.Join more than 500 other researchers and clinicians from more than 30 countries