tbuckley/cabot-search huggingface dataset:
Estrogenic Activity Assessment of Environmental Chemicals Using in Vitro Assays: Identification of Two New Estrogenic Compounds
Authors: Isabelle Lascombe, Dominique Beffa, Urs Ruegg, Joseph Tarradellas, Walter Wahli
Journal: Environmental Health Perspectives (2000)

Environmental chemicals with estrogenic activities have been suggested to be associated with deleterious effects in animals and humans. To characterize estrogenic chemicals and their mechanisms of action, we established in vitro and cell culture assays that detect human estrogen receptor [alpha] (hER[alpha])-mediated estrogenicity. First, we assayed chemicals to determine their ability to modulate direct interaction between the hER[alpha] and the steroid receptor coactivator-1 (SRC-1) and in a competition binding assay to displace 17ss-estradiol (E(2)). Second, we tested the chemicals for estrogen-associated transcriptional activity in the yeast estrogen screen and in the estrogen-responsive MCF-7 human breast cancer cell line. The chemicals investigated in this study were o,p'-DDT (racemic mixture and enantiomers), nonylphenol mixture (NPm), and two poorly analyzed compounds in the environment, namely, tris-4-(chlorophenyl)methane (Tris-H) and tris-4-(chlorophenyl)methanol (Tris-OH). In both yeast and MCF-7 cells, we determined estrogenic activity via the estrogen receptor (ER) for o,p'-DDT, NPm, and for the very first time, Tris-H and Tris-OH. However, unlike estrogens, none of these xenobiotics seemed to be able to induce ER/SRC-1 interactions, most likely because the conformation of the activated receptor would not allow direct contacts with this coactivator. However, these compounds were able to inhibit [(3)H]-E(2) binding to hER, which reveals a direct interaction with the receptor. In conclusion, the test compounds are estrogen mimics, but their molecular mechanism of action appears to be different from that of the natural hormone as revealed by the receptor/coactivator interaction analysis.
Acute Otitis Media.
Authors: J. HOLINGER
Journal: JAMA (1897)

Chicago, March 16, 1897. <h3>To the Editor:</h3> —In theJournalof Feb. 27, 1897, a paper appeared on "Otitis Media" by Merrill Hopkinson, M.D., of Baltimore. After having favorably referred to Dr. Pierce's paper on this subect (JournalDec. 19, 1896) he disagrees with the latter especially as regards treatment, on account of an experience he had in his own person. Dr. Hopkinson was suffering from an acute otitis media produced by using a nasal douche in a "mild attack of post-nasal catarrh." Dr. H. should have known of the violent protests against the use of the nasal douche in every little affection of the nose. The only one indication for this procedure is the removal of crusts in ozena. Even there it is not fair to let a patient use it until the physician is perfectly convinced that it is well applied. After the douche the nose should be
No Health Coverage for 41 Million
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lidocaine: antiarrhythmic panacea or cardiac cosmetic agent
Authors: B. Lown
Journal: JAMA (1981)

At the very inception of the coronary care unit (CCU) era, lidocaine hydrochloride became the mainstay of antiarrhythmic drug therapy. Introduction of this agent was considered the basis for decrease in the 30% fatality rate recorded among hospitalized patients with acute myocardial infarction.<sup>1</sup>This fatality rate had prevailed unchanged over many decades. A number of studies, however, failed to provide convincing evidence demonstrating a lessened incidence of ventricular fibrillation after the use of lidocaine. Neither the expressed doubts of the academic world nor the absence of hard data quenched the enthusiasm or restrained CCU physicians from enfilading all comers with lidocaine. A<i>Lancet</i>editorial demurring of this practice recalled the injunction of Pasteur to "keep your enthusiasm but let strict verification be its constant companion."<sup>2</sup> It is worth examining the basis for the widespread acceptance of lidocaine therapy. The focus of care in the early CCUs was on
Critical Issues in Air Pollution Epidemiology
Authors: Morton Lippmann, Paul J. Lioy
Journal: Environmental Health Perspectives (1985)

The epidemiological studies which have had significant impact on the setting of National Ambient Air Quality Standards (NAAQSs) were performed more than twenty years ago. Most of the more recent studies have been seriously flawed in their design and/or execution because they neglected to account for important variables such as: pollutant exposures other than those from ambient air; the influence of personal activity on pollutant uptake; host responsiveness; and the separate contributions of recent transient peak exposures and long-term chronic exposures on the effects endpoints. For particulate pollutants, the influence of composition and size distribution has also received too little consideration. In order to address these deficiencies, research and methods development are needed on: indices for particulate exposures; identification of exposures relevant to the effects; improved indices of effects; acquisition of response data; identification of exposed populations; and identification of susceptible subgroups. Approaches to these needs are discussed, along with brief reviews of several recent studies that have focused on critical issues of concern, made the necessary efforts to characterize the relevant exposures of the populations being studied, and demonstrated human responses to ambient pollutants at current exposure levels.
Hysterectomy among women of reproductive age. Trends in the United States, 1970-1978
Authors: R. C. Dicker
Journal: JAMA (1982)

An estimated 3.5 million women aged 15 to 44 years in the United States underwent hysterectomy (excluding radical procedures) between 1970 and 1978. Data from the National Center for Health Statistics were used to study the influence of age, race, and geographic region on hysterectomy rates, surgical approach, and concurrent oophorectomy. The number and rate of hysterectomies increased between 1970 and 1972 but remained stable thereafter. Hysterectomy rates increased with age, and rates for black women slightly exceeded the rates for whites. Rates were consistently highest for women in the South and lowest for women in the Northeast. Women undergoing hysterectomy in the Northeast had the lowest percentage performed by a vaginal approach and the highest percentage performed in conjunction with bilateral oophorectomy. Women having a hysterectomy in the West had the highest percentage performed by a vaginal approach. (<i>JAMA</i>1982;248:323-327)
THE BRITISH MEDICAL BENEVOLENT FUND AND GUILD
Authors: A. M. Bedford, K. Westminster, E. Broadbent, M. Thorne, R. D. Powell, H. T. Butlin, W. S. Church, T. Barlow, J. Tweedy, S. West
Journal: BMJ (1910)

To the Editor of The Hospital Sir,?The tragic fate of Dr. Wells, of St. Mary's Hos- pital, whose death last October, at the age of thirty years, was caused by contracting glanders in the exercise of his duties, aroused the sympathy of the public and has drawn attention to the dangers to which all medical men are ex- posed in the pursuit of their profession.Accident or disease may cut short the career of a medical man, or other adverse circumstances may prevent him from making any provision for old age, so that he himself and those dependent upon him may be left in actual want and even encumbered with debt.
Disseminated Mycobacterium kansasii infection complicating hairy cell leukemia
Authors: J. L. Manes
Journal: JAMA (1976)

<i>Mycobacterium kansasii</i>was isolated from the spleen of a patient with "hairy cell leukemia" (HCL) who had caseating necrosis in the spleen and in the liver. The disseminated infection in this patient suggests a cellular immunity deficit. Despite intensive investigations, the nature of the cell of origin in HCL remains unknown. (<i>JAMA</i>236:1878-1879, 1976)
Inversio Uteri
Authors: J. Wallace
Journal: BMJ (1879)

direction of the upper axis of the pelvis, upwards and forwards towards the proecordia."Nothing more of a practical nature relating to the line in which force should be used can be added to these words.In inventing my repositor, I have endeavoured to construct it in such a form as to make it possible to carry out Gooch's instructions.The rod which supports the cup has been doubly bent, and has a pelvic and a perineal curve.With this instrument, the fundus of the inverted uterus maybepressed " uppwards andforwards"in a direct linewiththe axis ofthe
An Address Delivered at the Opening of the Section of Public Medicine
Authors: F. de Chaumont
Journal: BMJ (1877)

Manchester cconjrres as a topic for discussion in this Section of our meeting.The operation of transfusion has had a checkered career, and, after being forgotten or neglected for long periods, is again attract- ing much attention.From a sketch of the history by the late Mr. Pettigrew and others, we learn that the earliest experiments in transfusion were made in France about i658 by Hansheau.Lower performed the operation in this country in i665.M. Denis, satirically described as a physician " plus occup6 des jeux de hazard, que des jeux de la machine ani- male", subjected a man to the experiment about the same time.Biva and Manfredi in Italy, and Sinnibaldus in Flanders, repeated the experiment only a few years later.The first four volumes of the Philo- sophical Transactions, which cover the years from i665 to 1704, con- tain records of several, but all unsuccessful, cases.After this time, the practice seems to have fallen into abeyance, although Dr. Harwood of Cambridge published a thesis on the subject in 1785, and endeavoured to rouse attention to its importance.It was not until 1824, when Dr. Blundell of Guy's Hospital reopened the question, that it gained distinct vitality.Dr. Blundell showed, by a series of experiments, that blood may be transfused with success and safety from one animal to another, provided they are the same species; but, if from one animal to another of different species, the result is fatal.MIM.Prevost and Dumas in France, and Bischoff in Germany, believed they had afterwards verified Dr. Blundell's conclusions; but Dr. Brown-Sequard has shown that there were fallacies in these experi- ments, and that, under certain conditions, the blood of other animals may be injected into the human body without danger, while he holds with Dieffenbach that defibrinated blood answers as well as fibrinated blood.Dr. Blundell performed the operation of transfusion eleven times with his own hand; in ten of these cases there was pressing danger from loss of blood, and in only four of these did he succeed in restoring the patient.The sparing results attained by Dr. Blundell did not encourage the adoption of the practice by medical men generally.The operation was regarded as delicate, difficult, and uncertain of success, and it languished, although from time to time new instruments were devised and fresh suggestions were made for perfecting the process.In later days, Dr. Hamilton of Ayr, Dr. Graily Hewitt, and Dr. Aveling have each suggested modifications of apparatus.Dr. Aveling's method of immediate transfusion was at once so simple and practical that its intro- duction gave a new impetus to the operation in this country.
Ofatumumab Combined with Fludarabine and Cyclophosphamide (O-FC) Shows High Activity in Patients with Previously Untreated Chronic Lymphocytic Leukemia (CLL): Results From a Randomized, Multicenter, International, Two-Dose, Parallel Group, Phase II Trial.
Authors: William G Wierda, Thomas J Kipps, Jan Dürig, Laimonas Griskevicius, Stephan Stilgenbauer, Jiri Mayer, Lukas Smolej, Georg Hess, Rasa Griniute, Francisco J Hernandez-Ilizaliturri, Swaminathan Padmanabhan, Michele Gorczyca, Geoffrey Chan, Ira Gupta, Marc Andersen, Claus Strange, Tina G Nielsen, Charlotte A Russell
Journal: Blood (2009)
National screening programme for aortic aneurysm
Journal: BMJ (2004)

They should stimulate debate on the impact of pharmacogenomics on the clinical environment and, conversely, on the effect of clinical factors on the development and implementation of pharmacogenomics.Other criteria and examples may well emerge in the course of such a discussion, and the clinical validity, utility, and uptake of these strategies may change along with advances in technology or revisions to how health professionals (particularly doctors and pharmacists) are trained.Pharmacogenomics and related genomic advances are clearly placing a unique lens on the multiple actors participating in the development, regulation, and prescription of drugs, as well as the complex interactions within our health systems.Finally, the ethical, legal, social, economic, and regulatory implications of such a framework require further investigation, including considerations of equity, distributive justice, and the particular opportunities and challenges presented by various health systems and their organisation.
THE PROBLEM OF MYELOMA
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
NEW NCI MONOGRAPH ON ORAL COMPLICATIONS OF CANCER THERAPIES
Journal: JNCI Journal of the National Cancer Institute (1990)

Journal Article NEW NCI MONOGRAPH ON ORAL COMPLICATIONS OF CANCER THERAPIES Get access JNCI: Journal of the National Cancer Institute, Volume 82, Issue 7, 4 April 1990, Page 633, https://doi.org/10.1093/jnci/82.7.633 Published: 04 April 1990
Investigation of Underlying Reasons of Factor VIII Deficiency in Haemophilia A Patients with Undetectable Mutations in the Factor VIII Gene.
Authors: Osman El-Maarri, Jörg Schröder, Claudia Klein, Rainer Schwaab, Anne Goodeve, Claude Negrier, Arthur Thompson, Alok Srivastava, Johannes Oldenburg
Journal: Blood (2006)
Interplay of PNPLA and HSD17B13 variants in modulating the risk of hepatocellular carcinoma among hepatitis C virus infected patients
Authors: Carla De Benedittis, Martina Crevola, Venkata Ramana Mallela, Matteo Nazzareno Barbaglia, Stefano Fangazio, Ceriani Elisa, Mattia Bellan, Cristina Rigamonti, Rosalba Minisini, Mario Pirisi
Journal: Journal of Hepatology (2020)
III. THE SOLDIER'S FOOT AND THE TREATMENT OF COMMON DEFORMITIES OF THE FOOT
Authors: R. Jones
Journal: BMJ (1916)

T74 t K'ZVIC~~~~~~MrnAx.JOUNa!. 74 the fact that practically the same number of lice is present on the body during the day.Probablv the distractions of the day keep thle rnind away from the peat, but at night, wlhen everytlhing is conducive to the desire for rest and comnfort, the mind is most sensitive to the sliglhtest irritation.Tlien the crawlina of the insects, their sharp stabs, the itchiness of eachi tiny wound, and the fierce desire to scratchl become intolerable.As one ma'i said, " You feel as if you could rive yourself to pieces."Sleep, at best, is broken and uneasy, but is usually impossible.Conse- quent upon loss of sleep, impaired vitality and mental weariness becotme very real miseries to the soldier, tlle value of whoin depends upon a high pitcll of bodily well- being.These are the soldier's most acute troubles, primarily due to lice at this front, but it must never be lost sight of that tlle nmenace of typlhus, possiblv more immineut at the Eastern fronts, is still present at thle Western.(To be contintued.) 4tofts on Kiflitary (IrtliwpaeIc5s.III.TIHE SOLDIER'S FOOT AND.THE TREAT- MEN'T OF COMMON DEFORMITIES OF THI3 FOOT.
"What Are You Going to Do With a 41-Year-Old Man?"
Authors: L. Lamberg
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Exciting potential of DNA vaccines explored
Authors: C. Marwick
Journal: JAMA (1995)

A TOTALLY new step in vaccine development is nearing clinical trials and, if successful, is headed for clinical practice. The new work may open the way to preventing diseases such as hepatitis C, tuberculosis, malaria, and those caused by the herpes simplex and human papilloma viruses—and even by the human immunodeficiency virus (HIV). However, influenza is likely to be the first candidate for clinical trial, although it may share primacy with a test of a vaccine against HIV, or perhaps hepatitis B, according to some authorities. The technology has opened the way to what Maurice R. Hilleman, PhD, director, Merck Institute for Therapeutic Research, West Point, Pa, calls "the future of vaccinology." The new approach involves delivering the gene sequences of the desired antigen into the host by inserting the gene for the antigen via a nonreplicating plasmid vector (<i>JAMA</i>. 1994;271:929-931). This is in distinction to the current approach, which
Typographical Errors in Table 2 and Text
Authors: Andrew Armstrong, Orjan Nordle, Michael Morris
Journal: JAMA Oncology (2018)

David L. Steward, MD; Sally E. Carty, MD; Rebecca S. Sippel, MD; Samantha Peiling Yang, MBBS, MRCP, MMed; Julie A. Sosa, MD, MA; Jennifer A. Sipos, MD; James J. Figge, MD, MBA; Susan Mandel, MD, MPH; Bryan R. Haugen, MD; Kenneth D. Burman, MD; Zubair W. Baloch, MD, PhD; Ricardo V. Lloyd, MD, PhD; Raja R. Seethala, MD; William E. Gooding, MS; Simion I. Chiosea, MD; Cristiane Gomes-Lima, MD; Robert L. Ferris, MD, PhD; Jessica M. Folek, MD; Raheela A. Khawaja, MD; Priya Kundra, MD; Kwok Seng Loh, MBBS; Carrie B. Marshall, MD; Sarah Mayson, MD; Kelly L. McCoy, MD; Min En Nga, MBBS; Kee Yuan Ngiam, MBBS, MRCS, MMed; Marina N. Nikiforova, MD; Jennifer L. Poehls, MD; Matthew D. Ringel, MD; Huaitao Yang, Md, PhD; Linwah Yip, MD; Yuri E. Nikiforov, MD, PhD
Incorrect Wording
Authors: Francois Eisinger, Claire Julian-Reynier, Hagay Sobol, Dominique Stoppa-Lyonnet, Christine Lasset, Catherine Nogues
Journal: JAMA (2000)

phylactic mastectomy should be performed (FIGURE).Respondents' answers were not correlated with women's age at the time of the survey, their disease status, or their genetic risk.In contrast, the age at which surgery hypothetically would be scheduled was strongly associated with the acceptability of prophylactic mastectomy.Only 4.7% ( 22) of patients and 10.9% (76) of physicians found the surgical intervention acceptable in women younger than age 35 years.Comment.Although prophylactic mastectomy may prolong life in women with a BRCA1 or BRCA2 mutation who accept the intervention, if the intervention is unacceptable to most women, particularly when suggested to women younger than 35 years, the age at which the benefit is expected to be the highest, prophylactic mastectomy is unlikely to have a substantial impact.The convergence of patient aversion, physician reluctance, and cautious institutional guidelines 4 will likely make prophylactic mastectomy a rarely performed procedure in France, even if other populations may find this strategy more acceptable.
Housing for Health: Papers Presented Under the Auspices of the Committee on the Hygiene of Housing of the American Public Health Association
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diagnostic performance of PIVKA-II in patients with hepatocellular carcinoma
Authors: Valeria Guarneri, Elisabetta Loggi, Carla Serra, Ranka Vukotic, Monica Cevenini, Carmela Cursaro, Alessandra Scuteri, Giovanni Vitale, Marzia Margotti, Silvia Galli, Claudio Galli, Pietro Andreone
Journal: Journal of Hepatology (2020)