tbuckley/cabot-search huggingface dataset:
THE LIMITATIONS OF A PURIN-FREE DIET
Authors: A. Bryce
Journal: BMJ (1909)

<h3>Abstract</h3> Understanding speech in a noisy environment is crucial in day-to-day interactions, and yet becomes more challenging with age, even for healthy aging. Age-related changes in the neural mechanisms that enable speech-in-noise listening have been investigated previously; however, the extent to which age affects the timing and fidelity of encoding of target and interfering speech streams are not well understood. Using magnetoencephalography (MEG), we investigated how continuous speech is represented in auditory cortex in the presence of interfering speech, in younger and older adults. Cortical representations were obtained from neural responses that time-locked to the speech envelopes using speech envelope reconstruction and temporal response functions (TRFs). TRFs showed three prominent peaks corresponding to auditory cortical processing stages: early (~50 ms), middle (~100 ms) and late (~200 ms). Older adults showed exaggerated speech envelope representations compared to younger adults. Temporal analysis revealed both that the age-related exaggeration starts as early as ~50 ms, and that older adults needed a substantially longer integration time window to achieve their better reconstruction of the speech envelope. As expected, with increased speech masking, envelope reconstruction for the attended talker decreased and all three TRF peaks were delayed, with aging contributing additionally to the reduction. Interestingly, for older adults the late peak was delayed, suggesting that this late peak may receive contributions from multiple sources. Together these results suggest that there are several mechanisms at play compensating for age-related temporal processing deficits at several stages, but which are not able to fully reestablish unimpaired speech perception. <h3>NEW &amp; NOTEWORTHY</h3> Older adults’ difficulty understanding speech in noise may be related to age-related changes in cortical temporal processing. Using magnetoencephalography to record responses of listeners under different noise conditions, we investigated both timing and strength of the cortical representation of continuous speech at several cortical processing stages. The representation at each stage depends differently on noise level and selective attention, and in different ways for older listeners, even with normal hearing, than younger.
Body Cholesterol Metabolism in Man. I. Equilibration of Serum and Tissue Cholesterol
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
JOURNALS ABSTRACTED IN THE CURRENT MEDICAL LITERATURE DEPARTMENT, JANUARY-JULY, 1941
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hypertension, peptic ulcer, and diabetes in air traffic controllers
Authors: S. Cobb
Journal: JAMA (1973)

The hypothesis that certain diseases might be unduly frequent in journeyman air traffic controllers working in towers and centers has been tested by reviewing the aeromedical certification examinations on 4,325 traffic controllers and 8,435 second class airmen. The subjects were all men who had an examination in 1969 to 1970 and at least one previous examination not more than two years before that. Quite compelling evidence has been adduced to support the hypothesis with regard to hypertension; on peptic ulcer the evidence is moderately strong and for diabetes it is slight but suggestive.
Flannery O'Connor's lupus. A commentary on her collected letters, The Habit of Being
Authors: R. Coles
Journal: JAMA (1980)

MILLEDGEVILLE, Ga, was the last capital of the Confederacy. Today it is a city of 12,000 people, with a mix of antebellum homes (still very much a presence and a continuing lure to tourists), an enormous mental hospital, and a growing number of light industries. Its real fame, however, is growing for other reasons. Flannery O'Connor, the short story writer and novelist from Milledgeville, died in early August 1964. She was only 39 years old and had disseminated lupus erythematosus since her mid-20s. The disease had claimed her father, Edwin O'Connor, who died in 1941 when Miss O'Connor was 15. Her mother, Mrs Regina (Cline) O'Connor, survives. A descendant of an old prominent southern family, she is now in her 80s. When she died, Flannery left a legacy of short stories, essays, and novels. (One of the novels,<i>Wise Blood</i>, was recently developed into a film and is currently playing
Infectious Disease
Authors: R. Gordon Douglas
Journal: JAMA (1987)

Far and away the area of greatest interest and accomplishment in infectious diseases over the past year is the acquired immunodeficiency syndrome (AIDS). Important advances have occurred in virology, immunology, and epidemiology, and, for the first time, there is a glimmer of hope in treatment and prevention. Approval of zidovudine (Retrovir, azidothymidine [AZT]) by the Food and Drug Administration slightly more than one year after the first patients were entered into a clinical trial is a remarkable achievement. Zidovudine is an analogue of thymidine. It enters cells, is phosphorylated by cellular kinases, competitively inhibits human immunodeficiency virus (HIV) reverse transcriptase, and terminates DNA chain formation. It is selective for viral reverse transcriptase and has little effect on host cell enzymes. Concentrations of 0.13 μg/mL or less can inhibit HIV replication. It is also active against the more classic retroviruses of some animals and against other lentiviruses, the family to which
FDA Approval of Second Diphtheria, Tetanus Toxoids, and Acellular Pertussis Vaccine
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Current concepts in cell-mediated hepatic allograft rejection leading to ductopenia and liver failure
Authors: R WIESNER
Journal: Hepatology (1991)

Recent improvement in survival after orthotopic liver transplantation has brought hepatic allograft rejection to the forefront as a major cause of morbidity and graft failure i l , 2).Indeed, up to 50% of late graft failures (more than 60 days after transplantation) are the result of hepatic allograft rejection.Rejection is broadly defined as the response of the recipient's immune system to the transplanted graft.leading to graft damage.The main targets in hepatic allograft rejection are the epithelium of bile ducts and the endothelium of arteries and veins (1. 3, 4).In liver transplantation, this damage has been classified primarily according to the prevailing histological changes, timing and reversibility.In this article, we examine our current understanding of' the most important form of rejection (i.e., cell-mediated rejection leading to ductopenia and liver failure) and specifically review terminology, pathogenesis, incidence, timing.risk factors and treatment-related problems. DEFINITIONSFor the purpose of this review.we use the adjective "cell-mediated" as a collective term for any form of hepatic allograft rejection that is not caused by preformed cytotoxic antibodies, as are observed in the rare cases of hyperacute rejection ( 5 . 6 ,.It is understood that the presence of cell-mediated rejection does not preclude the action of other antibodies.A schematic representation of the spectrum of cell-mediated hepatic allograft rejection defined herein is shown in Figure 1.Cellular Rejection.Traditionally, two forms of cellmediated rejection have been recognized -acute rejection and chronic rejection.The former is considered potentially reversible, whereas the latter is considered irreversible.Many publications describe the findings in these two conditions, but they do not actually define them.The name "acute rejection," a purely histolog~al definition, is now implicitly used in most centers.Thus
index to advertisers
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Rabies Vaccination
Authors: Paul Diamond
Journal: JAMA (1988)

<h3>To the Editor.</h3> —I was surprised to see the article entitled "Human Rabies Despite Treatment With Rabies Immune Globulin and Human Diploid Cell Rabies Vaccine—Thailand" in the LEADS FROM THE MMWR in the Jan 1 issue of<i>JAMA</i>.<sup>1</sup>Development of rabies despite treatment is not a rare occurrence. In Choomkasien and Wasi's<sup>2</sup>review of 707 cases of human rabies deaths between 1979 and 1986 in Thailand, 7% of the patients who died had completed a full vaccine course following exposure. Of this 7%, there were nine patients who appeared to represent failures of tissue-culture vaccines. All nine had completed the full course of vaccine. Five had received human diploid cell rabies vaccine, three had received purified chick embryo cell rabies vaccine, and one had received purified VERO cell rabies vaccine. Of these nine patients, three patients had received equine rabies immune globulin and one had received human rabies
IODIZED CATGUT.
Authors: NICHOLAS SENN
Journal: JAMA (1903)

Absorbable suture and ligature material has held its place in surgery since Lister first introduced it into general practice. At times it has appeared as though it would become displaced by inabsorbable permanent material, but the general tendency at the present time seems to be in its favor. The improvements which have been made during the last decade in the sterilization of catgut and other absorbable animal sutures have contributed much in establishing and maintaining the confidence of surgeons in their use. There can be very little doubt that catgut will eventually render silk and metal obsolete as materials for buried sutures. Nature abhors foreign material of all kinds in the living tissues. The ideal material for ligatures and sutures is one that is removable by absorption after it has accomplished the mechanical purposes for which it was employed. During my four months' tour through Europe and the Orient last summer
Editorial Board
Authors: Bruce Thiers, Dirk Elston, Detra Davis, Anna Krueger, Kenneth Katz, Jack Lesher, Mary Spellman, Jeffrey Weinberg, Dermatologic Surgery, Clifford Perlis, Julie Prendiville, Frcpc Dermatopathology, John Maize, Social Media, Emily Altman, Robert Dellavalle, J Smith, Editors Emeritus, Richard Dobson, Jeffrey Bernhard, Calvin Mccall, Brett Sloan, James Solomon, Stephen Tyring, George Hruza, Pediatric Dermatology, Kelly Cordoro, Dermatopathology Carlson, Tammie Ferringer, Cyberdermatology Consultant, Daniel Siegel, Clara Kim, Bryan Anderson, Salvador Arias-Santiago, Trisha Beute, John Binhlam, Diana Bolotin, Markus Braun-Falco, Nooshin Brinster, Patrick Carrington, Zoe Draelos, Nananamibia Duffy, Laura Ferris, David Fivenson, Joel Gelfand, Camille Introcaso, Nathaniel Jellinek, Jonathan Kantor, Matthew Kanzler, Kevin Kia, Nikki Levin, J Am, Acad Dermatol
Journal: Journal of the American Academy of Dermatology (2014)
Strikingly Homologous Immunoglobulin Gene Rearrangements and Poor Outcome in VH3-21-Utilizing Chronic Lymphocytic Leukemia Independent of Geographical Origin and Mutational Status.
Authors: Fiona Murray, Mia Thorselius, Alexander Krober, Ulf Thunberg, Gerard Tobin, Andreas Buhler, Dirk Kienle, Emilia Albesiano, Lan-Phuong Dao-Ung, James Wiley, Juhani Vilpo, Anna Laurell, Goran Roos, Karin Karlsson, Nicholas Chiorazzi, Roberto Marasca, Hartmut Dohner, Stephan Stilgenbauer, Richard Rosenquist
Journal: Blood (2005)
Acute phosphine poisoning aboard a grain freighter. Epidemiologic, clinical, and pathological findings
Authors: R. Wilson
Journal: JAMA (1980)

Two children and 29 of 31 crew members aboard a grain freighter became acutely ill after inhaling the toxic fumigant phosphine; one child died. Predominant symptoms were headache, fatigue, nausea, vomiting, cough, and shortness of breath. Abnormal physical findings included jaundice, paresthesias, ataxia, intention tremor, and diplopia. Focal myocardial infiltration with necrosis, pulmonary edema, and widespread small-vessel injury were found at postmortem examination of the dead child. The surviving child showed ECG and echocardiographic evidence of myocardial injury and transient elevation of the MB fraction of serum creatinine phosphokinase. Illness was significantly associated with living or working amidships or on the forward deck areas of the vessel. Phosphine gas was found to have escaped from the holds through a cable housing located near the midships ventilation intake and around hatch covers on the forward deck. The outbreak illustrates the hazards associated with shipboard fumigation. (<i>JAMA</i>244:148-150, 1980)
Translational Highlights from The Endocrine Society Journals
Authors: Matthew Ernst, Ian Haidl, Luis Zu ´n ˜iga, Helen Dranse, Jillian Rourke, Brian Zabel, Eugene Butcher, Christopher Sinal, Kathryn Guerriero, Kim Keen, Robert Millar, Ei Terasawa, Motoko Kanzaki, Jun Wada, Koichi Sugiyama, Atsuko Nakatsuka, Sanae Teshigawara, Kazutoshi Murakami, Kentaro Inoue, Takahiro Terami, Akihiro Katayama, Jun Eguchi, Hisaya Akiba, Hideo Yagita, Hirofumi Makino, Liese Mebis, An Eerdekens, Fabian Gu, Leslie Princen, Sarah Derde, Yoo-Mee Vanwijngaerden, Ilse Vanhorebeek, Veerle Darras, Lies Langouche, Lars Madsen, Jeffrey Knauf, Carsten Gotfredsen, Andrew Pilling, Ingrid Sjo ¨gren, Søren Andersen, Lene Andersen, Anne Sietske De Boer, Katia Manova, Afsar Barlas, Sushil Vundavalli, Niels Berg Nyborg, Lotte Knudsen, James Fagin, Christian Benedict, Samantha Brooks, Owen O'daly, Markus Alme, Arvid Morell, Karin Åberg, Malin Gingnell, Bernd Schultes, Manfred Hallschmid, Jan-Erik Broman, Elna-Marie Larsson, Helgi Schio, Paraskevi Xekouki, Karel Pacak, Madson Almeida, Christopher Wassif, Pierre Rustin, Maria Nesterova, Maria De La, Luz Sierra, Joey Matro, Evan Ball, Monalisa Azevedo, Anelia Horvath, Charalampos Lyssikatos, Martha Quezado, Nicholas Patronas, Barbara Ferrando, Barbara Pasini, Aristides Lytras, George Tolis, Constantine Stratakis, John Mark, P Pabona, Frank Simmen, Mikhail Nikiforov, Dazhong Zhuang, Kartik Shankar, Michael Velarde, Zara Zelenko, Linda Giudice, Rosalia Simmen
Journal: Endocrine Reviews (2012)

Adipose tissue secretes a variety of bioactive signaling molecules, termed adipokines, which regulate numerous biological functions including appetite, energy balance, glucose homeostasis, and inflammation.Chemerin is a novel adipokine that regulates adipocyte differentiation and metabolism by binding to and activating the G protein-coupled receptor, chemokine like receptor-1 (CMKLR1).In the present study, we investigated the impact of CMKLR1 deficiency on adipose development, glucose homeostasis, and inflammation in vivo.Herein we report that regardless of diet (low or high fat), CMKLR1 Ϫ/Ϫ mice had lower food consumption, total body mass, and percent body fat compared with wild-type controls.CMKLR1 Ϫ/Ϫ mice also exhibited decreased hepatic and white adipose tissue TNF␣ and IL-6 mRNA levels coincident with decreased hepatic dendritic cell infiltration, decreased adipose CD3ϩ T cells, and increased adipose natural killer cells.CMKLR1 Ϫ/Ϫ mice were glucose intolerant compared with wild-type mice, and this was associated with decreased glucose stimulated insulin secretion as well as decreased skeletal muscle and white adipose tissue glucose uptake.Collectively these data provide compelling evidence that CMKLR1 influences adipose tissue development, inflammation, and glucose homeostasis and may contribute to the metabolic derangement characteristic of obesity and obesity-related diseases.
An Introduction to the Symptoms and Signs of Clinical Medicine
Authors: A. Youzguin
Journal: Journal of the Royal Society of Medicine (2002)

Bodies Politic: Diseases, Death and Doctors in Britain, 1650±1900How do you picture history?Conventional visual images from the past portray their subjects in an ostensibly realistic manner, but others convey more personal messages from the artist.Such messages may be coded, or transmitted with brutal directness.Individual people, events and places are transformed into stereotypes and metaphors to provide comment on more general social or political situations, usually with strong overtones of parody, protest or subversion.The subjects are to varying degrees remodelled to form caricatures, which range from the comical to the repulsive.Such images are often supplementary to or indeed directly linked with verbal images in the novels, plays, poems and pamphlets of the times and, to this extent, the visual and the verbal cannot be separated.Both provide valuable commentary on the historical contexts in which they are set.Bodies Politic 1 is one of a new series entitled `Picturing History', and British medicine between 1650 and 1900 provides abundant material for Professor Roy Porter to develop several questionsÐnotably, `How did the body and healing practices . . .supply metaphoric commentary upon the wider world of politics and the body politic?'.The emphasis inevitably falls on `the long eighteenth century', on metropolitan rather than provincial practice, and on patients `of the better sort' with time and money at their disposal.Views of the body itself were inherently con¯icting during this periodÐloathsome object or divine handiwork?Thus Gibbon disliked `. . . the naked frankness of Montaigne who exposes all his malady and the operation of each dose of physic on his nerves and bowels', and he was painfully distressed by his own last and unpleasant illnessÐ `varnish the business for the ladies'.Gibbon's less fastidious contemporaries were, however, deeply interested in other people's bodily misfortunes.Publicity was guaranteed for giants, dwarfs and the malformed, and visits to `the Poore lunatiques' at Bethlem hospital provided (according to taste) edi®cation or raucous sport up until 1770.Mary Toft from Godalming, who claimed to give birth to litters of rabbits, was displayed in London in 1726, and was recorded by Hogarth.Rare but profound enjoyment was to be had from botched executions, and the case of Ann Green, hanged in Oxford in 1650, was widely reported.Anthony a Á Wood recorded that `she was carried away to be anatomized by
La rate organe réservoir.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal