tbuckley/cabot-search huggingface dataset:
Substance Abuse
Authors: Donald R. Wesson
Journal: JAMA (1984)

A report of The National Institute on Drug Abuse<sup>1</sup>indicates that drug use trends in 1982 show a reversal of the upward trend of drug use observed between the years 1971 and 1979. This conclusion is based on a household survey of drug use involving interviews with more than 5,000 persons from a randomly selected stratified sample of persons aged 12 years and older. For example, the percentage of youths (12 to 17 years old) who have "ever used" marijuana was 27% in 1982, slightly lower than the 31% obtained in the 1979 survey. In the 1982 survey, 12% of youths reported use of marijuana during the month before the interview, whereas in 1979 the corresponding figure was 17%. Physicians are more aware of the problem of cocaine abuse because the number of persons seeking treatment for cocaine dependency or complications of cocaine abuse are increasing. An increase in the
Sittings with Eusapia Palladino, &amp;amp; Other Studies.
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A randomized, prospective evaluation comparing intensity of lymphodepletion prior to adoptive transfer of tumor infiltrating lymphocytes for patients with metastatic melanoma.
Authors: Stephanie L. Goff, Mark Dudley, Deborah E. Citrin, Robert Somerville, John R Wunderlich, David N. Danforth, Daniel A Zlott, James C. Yang, Richard Mark Sherry, Udai S. Kammula, Christopher Klebanoff, Marybeth S. Hughes, Nicholas P. Restifo, Mei Li Kwong, Sadia Ilyas, Nicholas Klemen, Eden Payabyab, Seth M. Steinberg, Donald E. White, Steven A. Rosenberg
Journal: Journal of Clinical Oncology (2016)

3006 Background: Adoptive cell transfer (ACT), the infusion of large numbers of activated autologous lymphocytes, can mediate objective tumor regression in a majority of patients with metastatic melanoma (52/93, 56%). The addition and intensification of total body irradiation (TBI) to the preparative lymphodepleting chemotherapy regimen in sequential trials improved objective partial and complete response rates. Here, we evaluated the importance of adding TBI to the adoptive transfer of tumor-infiltrating lymphocytes (TIL) in a randomized fashion. Methods: 101 patients with metastatic melanoma, including 76 with M1c disease, were randomly assigned to receive nonmyeloablative chemotherapy with or without 1200 cGy TBI prior to transfer of TIL. The primary endpoints were complete response rate (as defined by Response Evaluation Criteria in Solid Tumors 1.0) and overall survival. Clinical and laboratory data were analyzed for correlates of response. Results: Complete response rates were 24% in both groups (12/50 v 12/51) and overall survival was also similar (median OS, 38.2 v 36.6 months; hazard ratio [HR], 1.11; 95% CI, 0.65 to 1.91, P= .71). Thrombotic microangiopathy was an adverse event unique to the TBI arm and occurred in 13/48 treated patients. With a median potential follow-up of 40.9 months, only one of the 24 complete responders recurred. Conclusions: Adoptive cell transfer with tumor-infiltrating lymphocytes can mediate durable complete regressions in 24% of patients with metastatic melanoma and a median survival greater than three years. Results were similar using chemotherapy preparative regimens with or without the addition of TBI . Clinical trial information: NCT01319565.
Anatomy
Authors: John E. Skandalakis
Journal: JAMA (1985)

<b>Functional Human Anatomy</b>, by James E. Crouch, ed 4; 645 pp, with illus, $32.50, Philadelphia, Lea &amp; Febiger, 1985. <i>Anatomy</i>, by Ernest W. April, PhD, is one of a series of seven basic science books entitled the<i>National Medical Series for Independent Study</i>. It is designed to be a review for students preparing for various national board examinations as well as for course examinations. The book is a brief, basic presentation of regional and systemic anatomy, divided into nine parts and 34 chapters. Each part includes a number of study questions in national board format. The correct answers and a short explanation of each are provided. The outline format is acceptable if not always ideal. The text contains some functional anatomy, some clinical applications, and a little basic physiology. It seems to be well crossreferenced, and the index is quite detailed. The illustrations are good, but the reproduction does not
&lt;TITLE&gt;Your child's respiratory health&lt;/TITLE&gt;
Journal: JAMA (1999)

public service of JAMA and the AMA.The information and recommendations appearing on this page are appropriate in most instances; but they are not a substitute for medical diagnosis.For specific information concerning your personal medical condition, JAMA and the AMA suggest that you consult your physician.This page may be reproduced noncommercially by physicians and other health care professionals to share with patients.Any other reproduction is subject to AMA approval.
RADIUM.
Authors: None E. T. C.
Journal: JAMA (1903)

Stanberry, Mo., July 20, 1903. <i>To the Editor</i>:—I notice an editorial on radium in the last issue ofThe Journal. Can you tell me where I can get a small quantity of the metal or its bromin salt? Ans.—Radium is hardly yet a commercial product, and samples are obtained more by favor than otherwise. It is thus far more of a scientific curiosity than anything else.
Moving ahead with health care system reform
Authors: J. D. Rockefeller
Journal: JAMA (1995)

For those of us who are committed to passing health care system reform legislation, the new year and new Congress will bring many changes and challenges. One problem we will confront is a proposal to redirect Medicare and Medicaid spending to help pay down the federal deficit, rather than to pay for health care system reform. Most of the comprehensive health care system reform bills of the last 2 years relied on reductions in projected spending of these two federal health programs. Savings from Medicare were to be used to finance additional Medicare benefits, such as prescription drugs, a home care program for disabled people of all ages, low-income subsidies, and, in some cases, even deficit reduction. Medicaid savings were generally to be used to pay for health care coverage for low-income families. The basic idea was that we could responsibly limit Medicare and Medicaid spending if we also expanded
Intensive case management does not reduce violence in psychosis
Journal: BMJ (2001)

Chickenpox can still kill adultsMore than four fifths of deaths from chickenpox are now in adults, compared with less than half 30 years ago.Chickenpox accounts for about 25 deaths annually in England and Wales, more than from measles, mumps, pertussis, and Hib meningitis combined.Deaths are twice as common in men as in women.Rawson and colleagues (p 1091) draw attention to the importance of chickenpox as a cause of death by examining 119 death certificates that mentioned chickenpox in England and Wales over a three year period.Chickenpox should therefore not be thought of as a innocuous disease.
Bone Lady
Authors: Erika E. Reid
Journal: Annals of Internal Medicine (2009)

Ad Libitum3 February 2009Bone LadyErika E. Reid, BAErika E. Reid, BAFrom Northwestern Medical School, Chicago, IL 60611.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-150-3-200902030-00030 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Do you all know how to sex a skeleton?Some people laughed because ... Author, Article, and Disclosure InformationAffiliations: From Northwestern Medical School, Chicago, IL 60611.Current Author Address: Erika E. Reid, BA, 600 North McClurg Court, Apartment 704A, Chicago, IL 60611. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 3 February 2009Volume 150, Issue 3Page: 228KeywordsBoneHipInterleukinsPelvisRibsSkeletonSkullSternumThoraxVertebrae ePublished: 3 February 2009 Issue Published: 3 February 2009 Copyright & PermissionsCopyright © 2009 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Sponsorship, Authorship, and Accountability
Journal: Annals of Internal Medicine (2002)

Letters5 February 2002Sponsorship, Authorship, and AccountabilityInternational Committee of Medical Journal EditorsInternational Committee of Medical Journal EditorsSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-136-3-200202050-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Mr. Holmer (for the Pharmaceutical Research and Manufacturers of America) presents one pole in the debate over studies funded by industry and performed by academics. Academic investigators and industrial sponsors both contribute to the accrual of new medical knowledge. An appropriate balance is struck when a novel treatment can be tested in an environment in which all data are freely available to all investigators. When a report is prepared for publication, the primary goal must be the fair, honest, accurate, and complete dissemination of the accrued information. The system is best served when there is no attempt to ... Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoSponsorship, Authorship, and Accountability Frank Davidoff , Catherine D. DeAngelis , Jeffrey M. Drazen , John Hoey , Liselotte Højgaard , Richard Horton , Sheldon Kotzin , Magne Nylenna , A. John P.M. Overbeke , Harold C. Sox , Martin B. Van Der Weyden , Michael S. Wilkes , and Sponsorship, Authorship, and Accountability Alan F. Holmer Sponsorship, Authorship, and Accountability, , , , , , and Metrics Cited byAuthorship Limits 5 February 2002Volume 136, Issue 3Page: 252KeywordsClinical trialsDrug research and developmentResearch design ePublished: 5 February 2002 Issue Published: 5 February 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Cancer at insulin injection site
Authors: E. Eisenbud
Journal: JAMA (1975)

THERE is a large and generally anecdotal literature suggesting a relationship between trauma and subsequent development of cancer. We report the development of cancer at the site of a common type of trauma, that of long-term insulin injection. <h3>Report of a Case</h3> A 35-year-old woman, in whom insulinrequiring diabetes mellitus had developed at age 15, had been receiving one daily dose of 15 units of insulin zinc suspension (Lente) for the past ten years. Her diabetes was complicated by retinopathy, neurogenic bladder, diarrhea, orthostatic hypotension, peripheral neuropathy, and proteinuria. Six months before admission she noted a 2 × 2-cm nontender swelling on the side of the right thigh, which she attributed to a local allergic reaction to insulin. One month before admission the swelling increased rapidly, and she developed pain in the right thigh, groin, and lower part of the back. Physical examination revealed a 10 × 12cm firm, nontender
Quantitative HBeAg varies in the different phases of HBV infection, and can predict therapeutic outcome in the setting of immunosuppression driven HBV reactivation
Authors: Lorenzo Piermatteo, Romina Salpini, Mohammad Alkhatib, Ada Bertoli, Alessandra Iuvara, Maria De Cristofaro, Giuseppina Cappiello, Carlotta Cerva, Carmine Minichini, Mario Starace, Mariantonietta Pisaturo, Nicola Coppola, Carla Fontana, Loredana Sarmati, Massimo Andreoni, Angelico Mario, Sandro Grelli, Francesca Ceccherini Silberstein, Carlo Federico Perno, Valentina Svicher
Journal: Journal of Hepatology (2020)
Notes and news
Journal: Annals of the Rheumatic Diseases (1989)

The 42nd World Health Day will be on the 7 April 1990.The idea is to increase general awareness of the needs and desires for good health.The theme chosen for 1990 is 'Our planet-our health.Think globally-act locally'.This takes place under the auspices of the World Health Organisation and as WHO points out, on the eve of the 21st century 1-7 billion people still lack access to safe water and 1-2 billion do not have adequate sanitation facilities; and much of the ill health in developing countries can be directly traced to water borne and water related diseases.Chemical pollution of the atmosphere, the soil, and the water is another great concern, particularly the effect of pollution on children, the elderly, and pregnant women.Concern for world health is obviously of importance to rheumatologists, so anything you can do in your own department to influence and promote improved health and access to care facilities will be both welcome and important.How about starting some new enterprise on the 7 April 1990?
Hypnotism, Animal Magnetism, and Hysteria: Abstract of an Address delivered at the Sheffield Philosophical Institute
Authors: E. Hart
Journal: BMJ (1892)

THE remarkable properties of the natural magnet, its capacity for action without contact, and the respective attracting and repelling powers of its two poles, have greatly impressed the imagination of mankind from a very early date; and, as Richer,I lBinet, and F6r6 have pointed out, the assumption that the amagnet possessed some mysterious influence on the body, capable of being turned to account in the cure of disease, was -prevalent in the Middle Ages.Magnetic rings were worn to -cure nervous diseases, and the electrotherapeutic frauds, follies, and delusions which are so rampant in the present day can boast a very ancient history of trickery, credulity, and folly.Electric rings, belts, and boxes were hung round the body in the time of Ciedon.Paracelsus characteristically taught "that the human body was endowed with a double mag- netism-that one portion attracted to itself the planets, and was nourished by them, whence came wisdom, thought, and 17
P1 General practitioner prescribing habits in asthma/COPD
Authors: M Polkey, D Kyroussis, T Fleming, J Moxham, Neville Rg, Clark Ra, K Mousley, M Rudolf, M Pearson, L Walsh, A Wong, S Cooper, A Guhan, M Pringle, E Tattersfield, J Watson, R Lewis, M Levy, G Barnes, M Howe, R Neville, A Jones', G Beniham', Bdw Harrison2, D Jarvis3, R Badmintdn4, N Wareham
Journal: Thorax (1996)

A physiological training benefit from pulmonary rehabilitation is more probable if the exercise intensity exceeds the anaerobic threshold; a convenient marker of anaerobic metabolismn being elevation of plasma lactate.Plasma lactataemia is buffered by bicarbonate with release Of C02; in severe COPD this places an unsustainable load on the respiratory muscle pump.In COPD IP'S ameliorates the loading experienced by the inspiratory muscles during treadmill exercise (Polkey et al AJRCCM 1996; in press).In the present study we sought to extend exercise induced lactataemia in patients with severe COPD using non-invasive inspiratory pressure support (IPS). 5 men with severe COPD (mean FEV, 0.661) performed 2 constant rate treadmill walks to a condition of severe dyspnoea; the second walk was supported by IPS delivered from a NIPPY ventilator (Friday Medical, London UK) and a full face mask.Plasma lactate was measured in arterialised blood drawn at baseline and at end exercise.A significant elevation in mean plasma lactate from baseline (1.83 mM/L) to end exercise of both the free (to 3.48 mM/L) and IPS assisted (to 2.82 mM/L) walks was observed (p<0.05).IPS resulted in a mean 136% increase in walking distance (p<0.05).We conclude that patients with severe COPD can prolong exercise induced lactataemia for longer if assisted with IPS.This technique warrants further study since it may prove to be a useful adjunct in pulmonary rehabilitation.P2
Mechanistic Isolationism
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Experts say AIDS pain 'dramatically undertreated'
Authors: J. Stephenson
Journal: JAMA (1996)

DESPITE ever more sophisticated strategies for treating human immunodeficiency virus (HIV) disease, researchers are finding that many patients suffer needlessly because physicians fail to recognize and alleviate AIDS-related pain. Studies show that although people with HIV infection and AIDS suffer pain comparable to that experienced by cancer patients, their pain is "dramatically undertreated, even in academic centers with a focus on HIV care," said William Breitbart, MD, at a recent international congress on pain held in Vancouver, British Columbia. "The story of pain in AIDS has been a story of neglect," noted Breitbart, of Memorial Sloan-Kettering Cancer Center, New York, NY. And the problem may be exacerbated by pressures of managed care that result in greater numbers of people with HIV and AIDS being cared for by primary care physicians, many of whom have little training or experience in managing chronic pain. "Most physicians haven't been trained in
Alcohol-Related Traffic Fatalities Among Youth and Young Adults—United States, 1982-1989
Journal: JAMA (1991)

Unintentional injuries account for approximately half of all deaths among young persons aged 15-24 years in the United States; of these deaths, approximately 75% involve motor vehicles. Although alcohol use increases the risk for a motor vehicle crash for all drivers, for young drivers the risk begins to increase at very low blood alcohol concentrations (BACs). Moreover, in young persons who drive after drinking, the relative risk for crash involvement is greater at all BAC levels than it is for older drinking drivers. This report summarizes data from the National Highway Traffic Safety Administration's (NHTSA) Fatal Accident Reporting System on trends in alcohol-related traffic fatalities (ARTFs) in the United States from 1982 through 1989; trends are presented for three groups of young persons (15- to 17-, 18- to 20-, and 21- to 24-year-olds) and are compared with those for adults aged greater than or equal to 25 years.
HGCSG 1201: Phase II study of trastuzumab with irinotecan in HER2-positive metastatic or advanced gastric cancer patients previously treated with trastuzumab
Authors: Y. Kawamoto, S. Yuki, T. Meguro, K. Hatanaka, M. Uebayashi, I. Iwanaga, M. Nakamura, K. Eto, H. Okuda, M. Abe, A. Aonuma, N. Abe, A. Sato, H. Nakatsumi, T. Muranaka, M. Yagisawa, K. Oba, Y. Sakata, N. Sakamoto, Y. Komatsu
Journal: Annals of Oncology (2017)
Announcement
Authors: R. Mohan, Malin Josephson, Bengt Arnetz, Vanja Blomkvist, John H. Greist, Lee Baer, Kenneth A. Kobak, D. Collier, Keith W. Wenzel, Eva Vingård, Töres Theorell, Lars Alfredsson, M. Brecelj-Anderluh, J.L. Treasure, Paul McCrone, Isaac M. Marks, Indra Tumur, Eva Kaltenthaler, Michael Ferriter, Catherine Beverley, Glenys Parry, Craig A. Yury, Jane E. Fisher, Valiollah Golkaramnay, Stephanie Bauer, Severin Haug, Markus Wolf, Hans Kordy, Paul Grossman, Ulrike Tiefenthaler-Gilmer, Annette Raysz, Ulrike Kesper, N. Micali, J. Holliday, A. Karwautz, M. Haidvogl, G. Wagner, F. Fernandez-Aranda, A. Badia, L. Gimenez, R. Solano, Richard Balon, M. Joyce Hirsch, Beate Wild, Michael Eichler, Hans.Christoph Friederich, Christian Schubert, Mechthild Hartmann, Stefanie Feiler, L. Baer, J. Greist, I.M. Marks, Wolfgang Herzog, Stephan Zipfel, Eva Skillgate
Journal: Psychotherapy and Psychosomatics (2007)
Abstract 465: Human enhancer of filamentation 1 is a mediator of hypoxia-inducible factor-1 alpha-mediated migration in colorectal carcinoma cells
Authors: Sun-Hee Kim, Dianren Xia, Sang-Wook Kim, Vijaykumar Holla, David G. Menter, Raymond N. DuBois
Journal: Cancer Research (2010)

Abstract Human enhancer of filamentation 1 (HEF1, also known as NEDD9 or Cas-L) is a scaffolding protein that is implicated in regulating diverse cellular processes, including cellular attachment, motility, cell cycle progression, apoptosis and inflammation. Here, we identify HEF1 as a novel hypoxia-inducible factor-1α (HIF-1α) regulating gene and reveal that HEF1 mediates hypoxia-induced migration of colorectal cancer (CRC) cells. Moreover, we found that HIF-1α binds to a hypoxia-responsive element (HRE) of the HEF1 promoter to activate its transcription under hypoxic conditions. We further demonstrate that inhibition of HIF-1α expression abolished hypoxia-induced HEF1 expression and promoter activity in CRC cells. Importantly, silencing of HEF1 significantly inhibited hypoxia-stimulated HIF-1α transcriptional activity by preventing the interaction between HIF-1α and the transcriptional coactivator p300. HEF1 silencing also reduced the expression of hypoxia-inducible genes including those regulating cell motility and inhibited cell migration under hypoxic conditions. Thus, the positive feedback loop may contribute to adaptive responses by CRC cells that encounter hypoxia during CRC progression. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 465.