Effect of Testosterone Therapy versus Other Factors on the Self-reported Sexual Satisfaction of Premenopausal Women
Authors: Hari Kumar, Jayaraman Muthukrishnan, Kirtikumar D. Modi
Journal: Annals of Internal Medicine (2008)

Letters2 September 2008Effect of Testosterone Therapy versus Other Factors on the Self-reported Sexual Satisfaction of Premenopausal WomenHari Kumar, KVS, MD, Jayaraman Muthukrishnan, MD, and Kirtikumar D. Modi, MD, DMHari Kumar, KVS, MDFrom Medwin Hospitals, Hyderabad 500 001, India.Search for more papers by this author, Jayaraman Muthukrishnan, MDFrom Medwin Hospitals, Hyderabad 500 001, India.Search for more papers by this author, and Kirtikumar D. Modi, MD, DMFrom Medwin Hospitals, Hyderabad 500 001, India.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-149-5-200809020-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We have some comments regarding the study by Davis and colleagues (1) on testosterone replacement in premenopausal women.The inclusion criteria specified for the study participants were an early-morning free testosterone level of 3.8 pmol/L or less (≤1.1 pg/mL). However, the mean free testosterone level at baseline as shown in Table 3 is more than 6 pmol/L (>2 pg/mL) in all the study groups. This seems contrary to the defined inclusion criteria.Of the 480 symptomatic women who were initially screened, 168 (35%) were ineligible because of free testosterone levels greater than the cutoff value (≤3.8 pmol/L ...References1. Davis S, Papalia MA, Norman RJ, O'Neill S, Redelman M, Williamson M, et al. Safety and efficacy of a testosterone metered-dose transdermal spray for treating decreased sexual satisfaction in premenopausal women: a randomized trial. Ann Intern Med. 2008;148:569-77. [PMID: 18413618] LinkGoogle Scholar2. Santoro N, Torrens J, Crawford S, Allsworth JE, Finkelstein JS, Gold EB, et al. Correlates of circulating androgens in mid-life women: the study of women's health across the nation. J Clin Endocrinol Metab. 2005;90:4836-45. [PMID: 15840738] CrossrefMedlineGoogle Scholar3. Martin-Loeches M, Ortí RM, Monfort M, Ortega E, Rius J. A comparative analysis of the modification of sexual desire of users of oral hormonal contraceptives and intrauterine contraceptive devices. Eur J Contracept Reprod Health Care. 2003;8:129-34. [PMID: 14667322] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Hari Kumar, KVS, MD; Jayaraman Muthukrishnan, MD; Kirtikumar D. Modi, MD, DMAffiliations: From Medwin Hospitals, Hyderabad 500 001, India.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoSafety and Efficacy of a Testosterone Metered-Dose Transdermal Spray for Treating Decreased Sexual Satisfaction in Premenopausal Women Susan Davis , Mary-Anne Papalia , Robert J. Norman , Sheila O'Neill , Margaret Redelman , Margaret Williamson , Bronwyn G.A. Stuckey , John Wlodarczyk , Karen Gard'ner , and Andrew Humberstone Effect of Testosterone Therapy versus Other Factors on the Self-reported Sexual Satisfaction of Premenopausal Women Susan R. Davis , Bronwyn G.A. Stuckey , John Wlodarczyk , Andrew Humberstone , and Robert J. Norman Effect of Testosterone Therapy versus Other Factors on the Self-reported Sexual Satisfaction of Premenopausal Women Liu Hong , Kaichun Wu , and Daiming Fan Metrics 2 September 2008Volume 149, Issue 5Page: 361KeywordsAndrogensConflicts of interestOral contraceptive therapySexual dysfunctionTestosterone ePublished: 2 September 2008 Issue Published: 2 September 2008 Copyright & PermissionsCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...