tbuckley/cabot-search huggingface dataset:
Shall We "Reproduce"?
Authors: Paul Ramsey
Journal: JAMA (1972)

In the previous issue ofThe Journal<sup>1</sup>I set forth the ethical objections against in vitro fertilization and embryo transplantation which can be drawn from applying to these experiments the received standards of medical ethics. Unless the ethics of the medical research profession is to be radically revised or abandoned, we ought not to manipulate at risk the child-to-be. I now want to take up certain answers to my argument. From the nature of these rejoinders we can clearly see the extent to which human procreation has already been replaced by the idea of "manufacturing" our progeny. Unless and until<i>that</i>concept is reversed, mankind's movement toward Aldous Huxley's Hatcheries must surely prove irreversible. It may be granted that the mimicry of natural fertilization, implantation, and the environment of the womb cannot be guaranteed to be perfect or without possibly harmful, induced impairments to the possible future child. It
Allen's Commercial Organic Analysis. A Treatise on the Properties, Modes of Analysis, and Proximate Analytical Examination of the Various Organic Chemicals and Products Employed in the Arts, Manufactures, Medicine, etc. With Concise Methods for the Detection and Estimation of Their Impurities, Adulterations, and Products of Decomposition.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abnormal Catecholamine Metabolism in Familial Dysautonomia
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A proposal for structured reporting of randomized controlled trials. The Standards of Reporting Trials Group
Authors: Erik Andrew, Aslam Anis, Tom Chalmers, Mildred Cho, Mike Clarke, David Felson, Peter Gøtzsche, Richard Greene, Alejandro Jadad, Wayne Jonas, Terry Klassen, Paul Knipschild, Andreas Laupacis, Curtis L. Meinert, David Moher, Graham Nichol, Andy Oxman, Marie-France Penman, Stuart Pocock, Joan Reisch, David Sackett, Kenneth Schulz, Judy Snider, Peter Tugwell, Jon Tyson, France Varin, Wikke Walop, Sharon Walsh, George Wells
Journal: JAMA (1994)

A RANDOMIZED controlled trial (RCT) is the most reliable method of assessing the efficacy of health care interventions.<sup>1,2</sup>Reports of RCTs should provide readers with adequate information about what went on in the design, execution, analysis, and interpretation of the trial. Such reports will help readers judge the validity of the trial. There have been several investigations evaluating how RCTs are reported. In an early study, Mahon and Daniel<sup>3</sup>reviewed 203 reports of drug trials published between 1956 and 1960 in the<i>Canadian Medical Association Journal</i>. Only 11 reports (5.4%) fulfilled their criteria of a valid report. In a review of 45 trials published during 1985 in three leading general medical journals, Pocock and colleagues<sup>4</sup>reported that a statement about sample size was only mentioned in five (11.1%) of the reports, that only six (13.3%) made use of confidence intervals, and that the statistical analyses tended to
Minerva
Journal: BMJ (2006)

reports of hip protectors, which absorb or spread the energy of a fall, were promising, but recent studies have questioned their effectiveness. 20 21 ConclusionsHip fracture is the most common disabling injury and cause of accidental death in older people.The incidence and the public health and economic consequences of this injury have risen as the population has aged, and this is expected to continue for the foreseeable future.The prevention and management of hip fractures involves a wide range of disciplines, and most people who sustain the injury require surgery followed by a period of rehabilitation.The complexity of care needed for hip fractures makes the condition a real test and a useful marker of the integration and effectiveness of modern health care.Competing interests: None declared by MP.AJ
Serum urate concentrations in male high-school students
Authors: S. V. Kasl
Journal: JAMA (1966)

The results of this study offer additional evidence of the relationship of serum uric acid (SUA) levels to achievement-oriented behavior. The SUA determinations were made on 62 male high-school junior- and senior— level students and were repeated 4 1/2 years later. The correlation between the two determinations was 0.76. The subjects were divided into three groups: (1) those who completed college (CC), (2) those who attempted college but dropped out (AC), and (3) those who did not attend college (NC). Evaluation of mean high-school grades among the three groups suggested that the AC group was more highly motivated to obtain further education, in spite of poor grades. The highest SUA levels were found in the AC group, and within this group, those who attended college for a longer length of time had higher SUA concentrations. First-born subjects, noted previously for their higher achievement needs, had higher SUA levels.
ACUTE REFLEX DISORDERS CAUSED BY THE CINEMATOGRAPH
Authors: George M Gould
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Software
Authors: Cheryl Iverson
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Monitoring the impact of cocaine
Authors: C. R. Schuster
Journal: JAMA (1991)

POLLOCK and coauthors<sup>1</sup>describe apparent discrepancies in two surveillance systems—the Drug Abuse Warning Network (DAWN), a survey of medical examiners and coroners, and the national vital statistics system—that monitor cocaine-related deaths. Over the years studied, both data systems did an excellent job of recording the dramatic increases in cocaine-related mortality. During the study period, the national vital statistics system reported a fivefold increase in cocaine-related deaths and DAWN reported a sixfold increase. Agreement in trends between these two major data systems confirms increasing cocaine-related mortality during this period of dramatic changes in cocaine use.
A Course of Lectures on Urine, Urinary Deposits, and Calculi
Authors: L. Beale
Journal: BMJ (1860)

Absenceof Albumen in Urine which contains a large Quantity;Cases.Cause of tile Precipitation of Albumen by Heat being prevented by a Trace of Nitric Acid.Other Tests for Albumen.On Estimating tile Quantity of Albumen.Peculiar Substance in Urine allied to Albumsen.Of the IImportance of Albumen in Urine in a Clinical point of view.Dropsy in Disease of the Kidney.BITE.Tests.Nitric Acid.Ileller's Test.Pettenkofer's Test.Yellow Colour of the Cells, etc., in the Urinary Deposit.On Estimating the Quantity of the Biliary Acids in Urine.SUGAR.General Characters of the Urine in Diabetes.Diabetic Sugar.Tests for Diabetic Sugar; Moore's Test; Trommer's Test ; Barreswill's and other Solutions.Onl Testing for Sugar when only Traces are present.Circum- stances interfering with the Action of Trommner's Test.Of the Yeast Test.llaumene's or tile Perchloride of Tin Test.Bismuth Test.Of Estimating tise Quantity of Sugar; volumetrically; by Fermentation; by Dr. Garrod's Method; by the Polarising Saccharimneter.Circumstances under which Sugar is excreted in the Urine.Analyses of Urine in Diabetes.OTHER SOLUBLE SUBSTANCES WHICH ARE NOT PRESENT IN HEALTH.LEUCINE.TYROSINE.
Serotonin
Authors: Albert Sjoerdsma
Journal: New England Journal of Medicine (1959)

(Concluded)Gastrointestinal DisordersAlthough it has been known for some time that the gastrointestinal tract contains the largest proportion of body serotonin, clinical studies relating to this fact have been rather belated.68 It is of interest that peptic ulcer has been noted to be unusually frequent in patients with the carcinoid syndrome.69 However, noncarcinoid persons with peptic ulcer, as well as those with achlorhydria,70 have been found to have normal 5-hydroxyindole-acetic acid values. Two so-called "ulcerogenic tumors" of the pancreas have been analyzed for serotonin in this laboratory, with negative results. To the present, serotonin is merely another addition to . . .
Hepatitis C is focus of NIH consensus panel
Authors: C. Marwick
Journal: JAMA (1997)

CONSENSUS conferences held by the National Institutes of Health (NIH) have almost always dealt with ways of managing a current clinical problem. In contrast, the most recent consensus meeting tried to deal with a future possibility: the emergence in the next few decades of an epidemic of hepatitis C. Nearly 4 million people in the United States are currently infected with hepatitis C virus (HCV). About 30000 new infections are diagnosed each year, and 8000 infected people die. "Without effective intervention, [those numbers are] expected to triple in the next 10 to 20 years," warned the consensus panel. Complications of HCV infection are now the major reason for liver transplantation in the United States. In the absence of any definitive treatment or preventive measure such as a vaccine, the panelists were charged, among other things, with recommending measures that physicians can take to slow the development of cirrhosis and ultimate
Molecular diagnosis of circulating cancer cells using MAGE gene assays
Authors: M. Mori
Journal: JAMA (1997)

<h3>To the Editor.</h3> —Reverse transcription—polymerase chain reaction (RT-PCR) of messenger RNA of a specific gene may be a powerful tool to detect small numbers of circulating cancer cells in the blood. With respect to common solid cancers, cytokeratin or carcinoembryonic antigen genes have been used as target genes for RT-PCR. However, these genes are not specific to cancer cells. Recently, a number of genes that code for tumor antigens have been isolated. Some of these genes are expressed in various tumors, but are otherwise silent in normal adult tissue, except for testes. Thus, these antigens appear to be potential targets for molecular diagnosis by RT-PCR. One of these genes that codes for tumor antigens is the<i>MAGE</i>gene, the name of which is derived from melanoma antigen.<sup>2</sup><i>MAGE</i>genes consist of 12 members and are localized on chromosome X.<sup>3</sup>We previously studied the expression of 10 of the
Smoke and Letters-Reply
Authors: Simon Chapman
Journal: JAMA (1994)

<h3>In Reply.</h3> —Mr Lee claims that in our letter we were "attempting indirectly to smear" his work. On the contrary, our letter responded to the Editorial by Dr Rennie,<sup>1</sup>commented in general terms about letters to the editor written by individuals affiliated with the tobacco industry, and did not cite the original letter by Mr Lee.<sup>2</sup> We stated that "many (or most) of the letters written, generated, or otherwise paid for by the tobacco industry are characterized by poorly informed, misleading, or downright silly arguments." Space does not permit a detailed presentation of examples of industry-generated letters that match our characterization. But perhaps an example will help illustrate our point. Dr Sharon Boyse, with the British-American Tobacco Company, criticized an article about ETS, using the argument that "of the more than 30 studies currently published on this topic, the vast majority (around 80%) do not report a statistically
Abstract P284: Antibody Levels to Persistent Pathogens and Incident Stroke in Mexican Americans
Authors: Shawnita Sealy-Jefferson, Brenda W Gillespie, Allison E Aiello, Mary N Haan, Lewis B Morgenstern, Lynda D Lisabeth
Journal: Circulation (2012)

Infectious pathogens such as Cytomegalovirus, Helicobacter Pylori, Toxoplasma gondii, Varicella Zoster and Herpes Simplex Virus Type 1 confer lifelong infections that are prone to reactivation. These pathogens may have an effect on ischemic stroke risk through an inflammatory pathway. Disparate rates of infectious disease and stroke risk have been documented for Mexican Americans (MAs) compared with Non-Hispanic Whites, thus exposure to persistent pathogens may help to explain the excess stroke burden in this population. We examined the hypothesis that high antibody response to 5 pathogens increases stroke risk in an elderly cohort of MAs. The study population included individuals followed from 1998-2008 as part of the Sacramento Area Latino Study on Aging (n=1789). Those with prevalent stroke at baseline were excluded (n=168). Seven annual in-person interviews and six semi-annual telephone interviews were conducted to ascertain clinical data and sociodemographics, with serum tested for IgG antibody levels. Antibody levels for each pathogen were modeled based on quartiles of the distributions. The outcome was self-reported incident stroke during follow-up. Associations between antibody levels for each pathogen and stroke risk were investigated using discrete-time logistic regression. We used baseline data and updated longitudinally collected covariate information if available. Mean age of our sample (n=1621) was 73.2 (SD=6.9), with 41% male. During the study, 164 incident strokes occurred. In demographic-adjusted models, no significant association was found between antibody levels for any of the pathogens and incident stroke. Similar results were found after additional adjustment for known stroke risk factors ( Table ). In conclusion, antibody levels to five persistent pathogens were not significantly associated with increased stroke risk in this elderly cohort of MAs. Given our results, future research should assess the effect of pathogen burden (or, the effect of &gt;1 pathogen), on stroke risk in MAs. Table. Antibody Levels to Persistent Pathogens and Incident Stroke Risk in MAs, California 1998-2008 Cytomegalovirus Herpes Simplex Virus Type1 Toxoplasma Gondii Varicella Zoster Virus Helicobacter Pylori Odds Ratio 95% CI P value Odds Ratio 95% CI P value Odds Ratio 95% CI P value Odds Ratio 95% CI P value Odds Ratio 95% CI P value 0.66 0.85 0.98 0.42 0.11 Quartile 2 0.79 0.48, 1.31 1.11 0.69, 1.80 0.94 0.59, 1.50 1.21 0.77, 1.92 0.94 0.56, 1.57 Quartile 3 0.99 0.62, 1.58 1.06 0.66, 1.69 0.94 0.58, 1.54 0.89 0.54, 1.46 1.53 0.97, 2.43 Quartile 4 0.79 0.48, 1.29 0.88 0.54, 1.43 0.91 0.56, 1.48 0.78 0.48, 1.28 1.51 0.94, 2.42 95% CI= 95% Confidence Interval; Adjusted for age, sex, diabetes, atrial fibrillation, smoking, coronary heart disease, hypertension, and hyperlipidemia
Intravenous Methotrexate Therapy in Treatment of Acute Leukemia
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Blunt cardiac trauma resulting in right atrial rupture
Authors: B. S. Getz
Journal: JAMA (1986)

Between 50,000 and 60,000 persons in the United States die each year as a result of motor vehicle accidents. It is estimated that myocardial rupture occurs in 10% to 15% of victims of fatal accidents. We recently cared for five patients with atrial rupture in the Columbus, Ohio, metropolitan area, and this experience has prompted this report. (<i>JAMA</i>1986;255:761-763)
Longing
Authors: Ted McMahon
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
University of Toronto Rheumatic Diseases Unit
Journal: Annals of the Rheumatic Diseases (1961)

DISEASESLes ecchymoses pathologiques peuvent constituer une complication serieuse de la therapie prolongee par des corticosteroides exog~nes. Equimosis corticosteroides SUMARIODurante un periodo de un afio, 58 enfermos con artritis reumatoide y con espondilartritis anquilosante, sometidos a terapeutica de larga duraci6n con cortico- steroides, fueron repetidamente examinados para com- probar la presencia o ausencia de equimosis patol6gicas.De 40 enfermos tratados con corticostercides exogenos, un 60 por ciento present equimosis patol6gicas, y entre 18 tratados con corticotropina ninguno fue afectado de esta manera.Las equimosis patol6gicos en tratamiento a largo plazo con corticoesteroides exogenos pueden ser una complicaci6n seria. UNIVERSITY OF TORONTOA new rheumatic diseases unit has been formed pital, a new thirty-bed long-stay active treatment within the Department of Medicine in the University division has been established at the Queen Elizabeth of Toronto with Dr. Wallace Graham, F.R.C.P., Hospital, Toronto.It is hoped to expand research as Director.facilities in the connective tissue diseases.