THE EXOERYTHROCYTIC CYCLE IN MALARIA
Authors: P. W. C.
Journal: Annals of Internal Medicine (1949)

Editorial1 May 1949THE EXOERYTHROCYTIC CYCLE IN MALARIAP. W. C.P. W. C.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-30-5-1065 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWhen a susceptible subject is bitten by mosquitoes infected with malaria and containing sporozoites in their salivary glands, no symptoms appear until after an incubation period of about 10 days. With or slightly before the development of clinical symptoms, parasites first are found in the blood in demonstrable numbers. Until recently there were no direct observations of the parasites during the interval between inoculation and the appearance of parasites in the blood; and their location and activities have been a matter of speculation.Schaudinn (1903) reported that after an infecting bite the sporozoites quite promptly penetrated into the red corpuscles,...1 JAMESTATE SPP: Exoerythrocytic schizogony in Plasmodium gallinaceum Brumpt. 1935, Parasitology, 1938, xxx, 128-139. CrossrefGoogle Scholar2 RAFFAELE G: Il doppio ciclo schizogonico di Plasmodium elongatum , Riv. di Malariol., 1936, xv, 309-317. Ibid.: Presumibli forme iniziali di evoluzione di Plasmodium relictum, Ibid., 318-324. Google Scholar3 HUFFCOULSTON CGF: The development of Plasmodium gallinaceum from sporozoite to erythrocytic trophozoite, Jr. Infect. Dis., 1944, lxxv, 231-249. CrossrefGoogle Scholar4 DAVEY DG: Concerning exoerythrocytic forms and the evidence for their existence in human malaria, Trans. Roy. Soc. Trop. Med. and Hyg., 1946, xl, 171-182. CrossrefGoogle Scholar5 ANGELINI G: Incertezza dei reperti di "forme esoeritocitiche" dei plasmodi della malaria umana nel midollo osseo, Riv. Parasitol., 1947, viii, 5-18. Google Scholar6 Editorial: Some specific antimalarial drugs, ANN. INT. MED., 1948, xxix, 746-751. Google Scholar7 SHORTTGARNHAM HEPC: Pre-erythrocytic stage in mammalian malaria parasites, Nature, 1948, clxi, 126. CrossrefGoogle Scholar8 SHORTTGARNHAMCOVELLSHUTE HEPCGPG: The pre-erythrocytic stage of human malaria, Plasmodium vivax , Brit. Med. Jr., 1948, i, 547. CrossrefGoogle Scholar9 HAWKINGPERRYTHURSTON FWLJP: Tissue forms of a malaria parasite, Plasmodium cynomolgi , Lancet, 1948, i, 783-789. CrossrefGoogle Scholar10 HUFFCOULSTON CGF: Symposium on exoerythrocytic forms of malaria parasites. II. Search for pre-erythrocytic stages of Plasmodium vivax and of P. cynomolgi , Jr. Parasitol., 1948, xxxiv, 264-274. CrossrefGoogle Scholar11 SHORTTGARNHAM HEPC: The pre-erythrocytic development of Plasmodium cynomolgi and Plasmodium vivax , Trans. Roy. Soc. Trop. Med. and Hyg., 1948, xli, 785-795. CrossrefGoogle Scholar12 SHORTTGARNHAM HEPC: Demonstration of a persisting exo-erythrocytic cycle in Plasmodium cynomolgi and its bearing on the production of relapses, Brit. Med. Jr., 1948, i, 1225-1228. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1949Volume 30, Issue 5Page: 1065-1069KeywordsBloodInoculationMalariaMosquitoesSalivary glandsSporozoites Issue Published: 1 May 1949 PDF downloadLoading ...