tbuckley/cabot-search huggingface dataset:
Endolymphatic Sac Tumors
Authors: Thomas J. Manski
Journal: JAMA (1997)

<h3>Objectives.</h3> —Isolated reports suggest a possible association of endolymphatic sac tumors (ELSTs), which are extremely rare in the general population, with von Hippel-Lindau disease (VHL). To determine if hearing loss and ELSTs are a component of VHL, we examined prevalence, clinical presentation, and natural history of hearing loss and ELSTs in VHL. <h3>Design.</h3> —Brain magnetic resonance images (MRIs) from 374 patients screened for VHL were reviewed for evidence of ELSTs. The VHL patients with MRI evidence suggestive of ELSTs or a history of hearing loss, tinnitus, or vertigo underwent additional radiologic and audiologic evaluations. To further assess prevalence of hearing loss and ELST in VHL, the next 66 patients screened in the VHL clinic (49 with proven VHL, 17 at risk for VHL) received MRI and audiologic assessment. <h3>Setting.</h3> —Referral center. <h3>Participants.</h3> —Study subjects comprised 374 persons screened for VHL, 66 consecutive patients with VHL or at risk for VHL, 4 patients with 6 ELSTs, and 13 previously reported patients with VHL and invasive tumors of the temporal bone. <h3>Intervention.</h3> —Magnetic resonance image and computed tomographic (CT) scan of the posterior fossa and audiologic assessment. <h3>Main Outcome Measures.</h3> —Any ELST visible on MRI or CT and hearing loss compatible with ELST. <h3>Results.</h3> —Magnetic resonance imaging revealed evidence of 15 ELSTs in 13 (11%) of 121 patients with VHL, but in none of the 253 patients without evidence of VHL (<i>P</i>&lt;.001). Clinical findings in these 13 patients included hearing loss (13), tinnitus (12), vertigo (8), and facial paresis (1). Mean age at onset of hearing loss was 22 years (range, 12-50 years). Hearing for pure tones was abnormal in all affected ears and in 6 of the 11 additional, allegedly unaffected ears. In 8 patients (62%), hearing loss was the first manifestation of VHL. Presence or absence of hearing loss was associated with duration of symptoms (<i>P</i>&lt;.002) and with tumor size (<i>P</i>&lt;.01). Further, 43 (65%) of the 66 patients from the VHL clinic had pure tone threshold abnormalities, abnormalities that occurred bilaterally in 23 (54%) of the 43 affected subjects; however, evidence is lacking for a definitive association with ELST (3 [6%] of 49 patients with proven VHL had ELST evident on MRI). <h3>Conclusions.</h3> —Hearing loss and ELSTs are frequently associated with VHL syndrome and should be considered when screening individuals at risk for VHL and when monitoring patients with an established diagnosis of VHL. Many patients with VHL have hearing loss without radiographic evidence of an ELST. Whether it is caused by an ELST that is too small to be detected by MRI or is produced by some other etiology is still unknown. Audiologic evaluation and MRI should allow early detection and enhance management of hearing loss in these patients.
A CASE OF CEREBELLAR ABSCESS DIAGNOSED POSTMORTEM
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Update: Sudden Unexplained Death Syndrome Among Southeast Asian Refugees—United States
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SPONTANEOUS LABOR IN A CASE OF DECENTRALIZED UTERUS
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Torment
Authors: Danielle Ofri
Journal: New England Journal of Medicine (2004)

I groan when I catch sight of her name on the patient roster. Nazma Uddin. Not again! She is in my clinic office almost every month. I dread her visits, and today is no exception. A small, plump woman, Mrs. Uddin is cloaked in robe, head scarf, and veil, all opaque blue polyester. Only her eyes peer out from the sea of dark blue. She is trailed, as usual, by her 11-year-old daughter Azina, who wears a light-green gown with a flowered head scarf pinned under her chin but no veil covering her solemn, bespectacled face.Mrs. Uddin flops into . . .
Identification of PD-L1-expressing exosome-derived microRNAs in human hepatocellular carcinoma
Authors: Yu Rim Lee, Jae Kyoung Seo, Gyeonghwa Kim, Se Young Jang, Soo Young Park, Won Young Tak, Young Oh Kweon, Jung Gil Park, Min Kyu Kang, Hye Won Lee, Keun Hur
Journal: Journal of Hepatology (2020)
Entero-Vioform
Authors: A. E. Bennett
Journal: JAMA (1972)

<h3>To the Editor.—</h3> In extensive foreign travels over the past 20 years I have found succinylsulfathiazole (Sulfasuxidine) a satisfactory prophylactic and very effective in therapy. It has also saved many vacations for traveling companions. Starting four days before departure with 0.5 gm twice a day prophylactically, at the first sign of cramping, nausea, or loose stools increase the dose to 2 to 3 gm daily, restricting the diet to tea, toast, and soup for 24 hours, then gradually increasing the diet. After the acute symptoms subside the prophylactic dosage is continued. Nothing in the discussion mentioned the most probable cause, namely the change of intestinal bacterial flora from unaccustomed foods. Diarrhea is not prevalent while traveling in Northern Europe or Scandinavia where the foods are similar to diets in the United States. It occurs frequently in Southern Europe, Africa, the Caribbean, Central and South America, and Asia. Also, travelers from
Starch Granulomatosis of the Peritoneum
Authors: G. Hyman
Journal: BMJ (1971)

47sarcoma, the histological appearances were those of a "hard fibroma," and the long history and complete lack of metastases do not suggest a malignant neoplasm.In retro- spect this was almost certainly the first account of the disease described some 10 years later by Riedel, and incidentally, of its association (and contiguity) with idio- pathic mediastinal fibrosis.Perhaps this tantalizing group of diseases, with its cumbersome and variable nomenclature, should be called "Bowlby's disease".-I am, etc.
Plea
Authors: Bhuvana Chandra
Journal: Annals of Internal Medicine (2010)

Ad Libitum4 May 2010PleaBhuvana Chandra, MDBhuvana Chandra, MDFrom Marshfield Clinic Research Foundation, Marshfield, WI 54449.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-152-9-201005040-00012 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Be my friend. This world pends heavywith the rot of quarrel; sap thickens blackin cankered twigs. Dragon's teeth displaceour oceans, our skies bleach in hatred's glare.We tread on our transgressionseverywhere we go; yet on our headsrest undecayed tomorrows. Like a fruit unpicked,left spoiling on its limb, shall our sour globebe as soon expunged? The harvest yet may come.We are of many yields; our mothers have but one womb.Our dreams are pleached by the same nightmare:whole fields untilled, sectored by tombs. So,come. Be my friend. Together, we'll nurture theorchards and dribble nectar on each other's tongue.Bhuvana Chandra, MDPorter Ranch, CA ... Author, Article, and Disclosure InformationAffiliations: From Marshfield Clinic Research Foundation, Marshfield, WI 54449.Current Author Address: Bhuvana Chandra, MD, PO Box 7694, Porter Ranch, CA 91327. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 4 May 2010Volume 152, Issue 9Page: 611KeywordsTongueUterus ePublished: 4 May 2010 Issue Published: 4 May 2010 Copyright & PermissionsCopyright © 2010 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Repelling Mosquitoes
Authors: Richard J Pollack, Anthony E Kiszewski, Andrew Spielman
Journal: New England Journal of Medicine (2002)

Widespread Coronary Inflammation in Unstable AnginaInflammation within a vulnerable coronary plaque may cause unstable angina by producing erosion or rupture.This study used measurements of neutrophil myeloperoxidase to assess neutrophil activation in blood from the aorta, femoral vein, and great cardiac vein.The data support the concept that in unstable angina there is widespread inflammation in the coronary bed, not just in a single vulnerable plaque.These findings add to a growing body of evidence that unstable coronary disease is associated with an inflammatory reaction throughout the coronary tree.There may be important therapeutic implications, since treatment of a single unstable plaque may not address the problem of widespread coronary inflammation.see page 5 (editorial, page 55) " DEET-based repellents remain the standard of protection under circumstances in which it is crucial to be protected against arthropod bites that might transmit disease." Comparative Efficacy of Insect Repellents against Mosquito BitesInsect-borne diseases are a major cause of illness and death worldwide.Insect repellents can reduce the risk of being bitten.In this study, volunteers inserted their arms into standardized mosquito-containing cages, and investigators calculated the elapsed time until the first bite in order to evaluate which repellent products available to consumers in the United States offered the most complete, reliable protection.Products containing high concentrations of N,N -diethyl-3-methylbenzamide (DEET) were most effective, with other products containing IR3535 or botanicals offering far less protection.Only DEET-based repellents provide adequate, long-lasting protection.Non-DEET-based repellents are unreliable in environments in which mosquito-borne diseases pose a substantial threat.
Overcoming Obstacles to Hospice Care: An Ethical Examination of Inertia and Inaction
Authors: Christopher K. Daugherty, David P. Steensma
Journal: Journal of Clinical Oncology (2002)

Article Tools THE ART OF ONCOLOGY: WHEN THE TUMOR IS NOT THE TARGET Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2002.20.11.2752 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 12039940 Overcoming Obstacles to Hospice Care: An Ethical Examination of Inertia and Inaction Christopher K. DaughertyxChristopher K. DaughertySearch for articles by this author , David P. SteensmaxDavid P. SteensmaSearch for articles by this author Show More From the Department of Medicine, MacLean Center for Clinical Medical Ethics, the Cancer Research Center at the University of Chicago, and Vitas Hospice, Chicago, IL, and Division of Medical Oncology, Department of Oncology and Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN. https://doi.org/10.1200/JCO.2002.20.11.2752 First Page Full Text PDF Figures and Tables © 2002 by American Society of Clinical Oncology
Timing of Antiretroviral Therapy for HIV-1–Associated Tuberculosis
Authors: Tom H Boyles
Journal: New England Journal of Medicine (2012)

3 (Oct.20 issue) consolidate the evidence base underpinning recommendations on when to start antiretroviral therapy (ART) in patients with human immunodeficiency virus (HIV)-associated tuberculosis.However, more than 80% of the global burden of this disease is in sub-Saharan Africa, where the health care infrastructure is weak and a lack of integration of the health care pathway represents a major hurdle to timely initiation of ART. 4 Patients typically attend completely separate HIV and tuberculosis clinics in different localities.In a township in South Africa, we found that delays in starting ART were almost three times as high in patients who were referred between nonintegrated tuberculosis services and ART clinics as in those with tuberculosis that was diagnosed in the ART clinic. 5Thus, among patients with CD4 counts of less than 50 cells per cubic millimeter who were referred to tuberculosis clinics, only 11% started ART within 4 weeks after receiving a diagnosis of tuberculosis.This is a prime example of how a lack of integration of tuberculosis and ART services compromises patient care.Progress toward integration is slow and must be accelerated.The time between tuberculosis diagnosis and initiation of ART might be a useful indicator of successful integration.
Quantitative Studies of Antigen Expression in Cultured Murine Lymphoma Cells. II. Cell-Surface Antigens in Synchronized Cultures2
Authors: Matko Cikes, Sten Friberg, George Klein
Journal: JNCI Journal of the National Cancer Institute (1972)

YAC murine lymphoma cells were synchronized with hydroxyurea (HU) at the boundary between the G1 and S periods. Relative H-2 antigen content was measured during synchronous growth by quantitative antibody absorption. S-phase cells had about a third as much H-2 antigens as the G1/S-phase cells. Reexpression of H-2 antigens after the first cell division following release from the G1 block depended on the final cell-density characteristic for the culture conditions. If the cells reached the final density after the first cell division following release from the G1 block, H-2 antigens were fully reexpressed, but if the final cell density was higher than the density attained after the first division, the H-2 antigen content remained low. In “asynchronous” logarithmically growing control cultures the H-2 content was in the range of the synchronized S-phase cells. Stationary-phase cells reversibly arrested in the G1 period could be released by dilution and incubation of cells in fresh medium. H-2 antigen expression in such cultures showed changessimilar to those in the cultures synchronized with HU. The results substantiate previous findings on cell cycle-dependent expression of membrane antigens studied with other immunological and synchronization procedures.
The scarier the better--screening results that make smokers stop smoking
Authors: Stephen Deppen
Journal: JNCI Journal of the National Cancer Institute (2014)

The scarier the better-screening results that make smokers stop smoking Screening for lung cancer leads to early detection and treatment, but can it also make people stop smoking before they get cancer?The answer is that it depends on the seriousness of the results, according to a study published May 28 in the JNCI: Journal of the National Cancer Institute.To determine if there is an association between type of screening result and smoking cessation, Martin C. Tammemagi of the Department of Health Sciences, Brock University in St. Catharines,
Radioimmunodetection of prostatic cancer. In vivo use of radioactive antibodies against prostatic acid phosphatase for diagnosis and detection of prostatic cancer by nuclear imaging
Authors: D. M. Goldenberg
Journal: JAMA (1983)

Radioimmunodetection (RAID) of prostatic cancer is done by injecting 131I-labeled rabbit antibody IgG against prostatic acid phosphatase (PAP) and performing total-body photoscans with a gamma scintillation camera. Of two patients tested, the PAP RAID scintiscans located the primary or recurrent prostatic cancers in both and showed no disease in the lungs of the patient shown subsequently to have lung cancer. The lung tumor nodules showing anti-PAP IgG accretion were assumed to be of prostatic cancer origin, since one of the original tumors removed from this patient's other lung a year earlier stained for PAP by immunohistochemistry. This study showed that PAP RAID can locate primary and metastatic tumors of prostatic origin.
Miscellanea Medica
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Old English Herbals.
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ASSOCIATION NEWS.
Authors: E. F. Brush
Journal: JAMA (1890)

<h3>American Medical Association.</h3> <i>Section on Diseases of Children</i>. All members of the American Medical Association who are interested in the subject of Pediatrics, are earnestly invited to prepare papers for reading in this Section at the meeting to be held at Nashville, Tenn., May 20, 1890. There can be no department of medicine which should appeal to all the workers of the profession more than the diseases of children. The outlook is favorable to a large attendance in this Section. Please send title of paper to either of the officers of the Section at as early a date as possible. (Signed) Office of the President, St. Louis, March 7, 1890.
Immunodeficiency virus slowly yields secrets
Authors: T. F. Kirn
Journal: JAMA (1988)

A TECHNICAL INNOVATION that allows investigators to select particular marrow cells from aspirate taken from the iliac crest of living subjects and the vertebral columns of cadavers has led to two discoveries about the human immunodeficiency virus (HIV). Investigators from the National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, Md, say that they have been able to infect normal hematopoietic progenitor cells with HIV in vitro. The implication: marrow may be a "potent" reservoir for the virus in the body. Moreover, Jan Marc Orenstein, MD, PhD, an associate professor of pathology at George Washington University Medical Center, Washington, DC, discovered through electron microscopy that the progenitor cells can produce new virions without budding them off the membrane. Rather, he says, oftentimes the cell will accumulate "scores" of virus in "internal compartments" deep within the cytoplasm. If that is occurring regularly in the human body, the progenitor cells theoretically could
Mass screening for sickle cell hemoglobin. Is there an optimal method?
Authors: R. M. Nalbandian
Journal: JAMA (1975)

The problem of screening large civilian and military populations for sickle cell hemoglobin and related conditions has been approached recently by three distinct methods. One method specifies hemoglobin electrophoresis as the initial screening technique, followed by a solubility (dithionite) test when a (nonspecific) "S band" is noted. Another method requires the use of the automated dithionite test, followed, when positive, by hemoglobin electrophoresis. A third method is a dual, automated technique for detecting anemia or hemoglobin S or both in the initial screening study; hemoglobin electrophoresis studies are done when indicated. All three methods provide data suitable for accurate diagnosis and genetic counseling, but substantial variations in costs and redundancy of data are found among these methods. Because it gives the "biggest diagnostic bang for the buck," the third merits widespread adoption. (<i>JAMA</i>234:832-835, 1975)