tbuckley/cabot-search huggingface dataset:
Operative Hand Surgery
Authors: Reginald R. Cooper
Journal: JAMA (1988)

This three-volume set certainly meets the goal of the author in compiling a comprehensive guide to management of hand and upper-extremity problems with special attention to operative technique. The list of authors represents a significant segment of "Who's Who" in hand surgery. These encyclopedic volumes actually represent a series of monographs. The length of some sections would certainly allow them to be published as a separate small volume. Dr Green has managed to insist that most of the numerous writers include some common features, which enhances the books. For the most part, the chapters are well written. The delineation of the "authors' preferred technique" adds a refreshing personal touch to an exhaustive work. Profuse photographs and excellent illustrations greatly enhance the written text. Inclusive bibliographies represent a valuable resource for those interested in any hand disorder. Dr Green sets the tone in chapter 1 by his excellent delineation of general
Transcription factor RUNX1 promotes survival of acute myeloid leukemia cells
Authors: Susumu Goyama, Janet Schibler, Lea Cunningham, Yue Zhang, Yalan Rao, Nahoko Nishimoto, Masahiro Nakagawa, Andre Olsson, Mark Wunderlich, Kevin A. Link, Benjamin Mizukawa, H. Leighton Grimes, Mineo Kurokawa, P. Paul Liu, Gang Huang, James C. Mulloy
Journal: Journal of Clinical Investigation (2013)

It has come to our attention that multiple HMGA1 bands in the immunoblot images of Figure 1,A,B, and D, and Figure 3D have been inappropriately duplicated.In addition, the p53 blots in Figure 1, A and B, appear to represent a darker exposure of the same blot.
Abstract 17849: Serum Vascular Endothelial Growth Factor Levels Associated With the Risk of Major Adverse Cardiac and Cerebrovascular Events After Drug-eluting Stent Implantation
Authors: Takashi Unoki, Daisuke Takagi, Kensuke Takabayashi, Suichi Ura, Akira Yamada, Yugo Yamashita, Yasuhiro Hamatani, Nobutoyo Masunaga, Mitsuru Ishii, Moritake Iguchi, Hisashi Ogawa, Noriko Satoh-Asahara, Akira Shimatsu, Mitsuru Abe, Masaharu Akao, Koji Hasegawa, Hiromichi Wada
Journal: Circulation (2015)

Background: Vascular endothelial growth factor (VEGF), a central player in angiogenesis, is not only involved in the progression of atherosclerotic plaque, but also required for preventing decompensated heart failure (HF). High circulating oxidatively modified LDL-cholesterol (oxLDL) levels are associated with vulnerability to the rupture of atherosclerotic lesions. However, the relationships of circulating VEGF and oxLDLs with major adverse cardiac and cerebrovascular events (MACCE) in patients undergoing coronary drug-eluting stent (DES) implantation are unclear. Methods and Results: We enrolled 441 patients who electively underwent coronary DES implantation. Patients were followed up over 2 years. MACCE were defined as cardiac and cerebrovascular death, acute coronary syndrome, stroke, and HF hospitalization. Revascularization for asymptomatic patients were excluded. Pre-procedural serum levels of high-sensitivity CRP (hsCRP), VEGF, and two oxLDLs, serum-amyloid-A/LDL complex (SAA-LDL) and α1-antitrypsin/LDL complex (AT-LDL), were measured. During a median follow-up of 720 (IQR, 498-720) days, MACCE developed in a total of 39 patients (8.8%). Patients were divided into two groups based on the median of each biomarker. In Kaplan-Meier analyses, high-VEGF and high-SAA-LDL ( P =0.009, P =0.0498 by log-rank test, respectively), but not high-hsCRP or high-AT-LDL, were significantly associated with MACCE. Multivariate Cox proportional hazard analyses revealed that natural log-transformed VEGF levels (Ln-VEGF) (HR, 1.9 per 1 SD increase; 95% CI, 1.3 to 3.0; P =0.001), but not Ln-SAA-LDL (HR, 1.2; 95% CI, 0.89-1.5, P =0.3), Ln-hsCRP, or Ln-AT-LDL, was significantly associated with MACCE after adjustment for age, sex, and established risk factors. Finally, we performed stepwise multivariate Cox proportional hazard analysis including possible confounders, such as the number of lesions and type of DES, and these biomarkers. Notably, the independent predictors of MACCE were age (HR, 1.8 per 10 years; 95% CI, 1.2-2.7; P =0.004), Ln-VEGF (HR, 1.9; 95% CI, 1.2-3.1; P =0.005) and chronic kidney disease (HR, 2.5; 95% CI, 1.2-5.0; P =0.01). Conclusions: A high VEGF value may serve as a predictor of MACCE following coronary DES implantation.
THE RATIONAL TREATMENT OF ARTERIAL HYPERTENSION
Authors: SOMA WEISS
Journal: JAMA (1930)

Functional and structural abnormalities of the peripheral vascular system, rather than the degree of elevation of the blood pressure, are the significant aspects of "persistent arterial hypertension." Because of the ease with which the systolic and diastolic arterial pressures can be determined, and because of the lack of clinical or laboratory methods for the evaluation and measurement of the peripheral vascular resistance, the height of the blood pressure has come to be considered the index of this resistance. The terms elevated blood pressure and increased vascular resistance, therefore, are frequently used interchangeably, even though a quantitative relationship between these two factors of the circulation does not always exist. Clinical terms such as hyperpiesia (Clifford Allbutt), hypertonia (Pal) and hypertensive cardiovascular disease (Theodore Janeway) define this clinical state of the cardiovascular system more accurately than the generally accepted terms, arterial hypertension and essential hypertension. The diagnosis of arterial hypertension in borderline
Proceedings of the British Thoracic Society
Authors: J Miotla, T Williams, P Hellewell, H Guite, A Fitzgerald, P Burney, Bdw Harrison, G Mohan, S Mildenhall, R Badminton, Ware- Ham For, East Anglian, B Mcdonough, S Watkin, Crk Hind, R Barker, J Harris, K Venables, A Newman, A Jarad, N Fasey, N Barnes, R Rudd, A Jackson, Cfj Rayner, P Cole, R Wilson
Journal: Thorax (1994)

We have shown that intravenous lipopolysaccharide (LPS) and zymosan treatment induces plasma protein accumula- tion in the lung, which is dependent upon neutrophil accumulation but not their emigration into alveolar interstitium (Miotla et al.Am Rev Respir Dis 147: A69).We have now investigated the role of PAF in the induction of neutrophil sequestration and vascular permeability changes.BALB/c mice (20 g) received i.v.LPS (3 mg/kg) two hours prior to i.v.zymosan (10mg/kg).The PAF antagonist, UK- 74 505 (0 5 mg/kg) was injected i.v. 15 minutes prior to LPS.Ac- cumulation of '52I-human serum albumin ('251I-HSA), co-injected Proceedings of the British Thoracic Society Table 2 Odds ratios for positive RAST to allergens D pteronyssinus Cat Grass NS 100 100 100 EXS 1 26 (0 75-2 08) 0 78 (0 37-1 60) 0 64 (0 39-1 05) Cs 1 60 (1 02-2 48) 0 47 (0 22-1 00) 0 45 (0 28-0 71) same for all allergens.[This work
Casopis Lekaru Ceskych, Praha
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
2017 Cardiovascular and Stroke Endpoint Definitions for Clinical Trials
Authors: Karen A. Hicks, Kenneth W. Mahaffey, Roxana Mehran, Steven E. Nissen, Stephen D. Wiviott, Billy Dunn, Scott D. Solomon, John R. Marler, John R. Teerlink, Andrew Farb, David A. Morrow, Shari L. Targum, Cathy A. Sila, Mary T. Thanh Hai, Michael R. Jaff, Hylton V. Joffe, Donald E. Cutlip, Akshay S. Desai, Eldrin F. Lewis, C. Michael Gibson, Martin J. Landray, A. Michael Lincoff, Christopher J. White, Steven S. Brooks, Kenneth Rosenfield, Michael J. Domanski, Alexandra J. Lansky, John J.V. McMurray, James E. Tcheng, Steven R. Steinhubl, Paul Burton, Laura Mauri, Christopher M. O’Connor, Marc A. Pfeffer, H.M. James Hung, Norman L. Stockbridge, Bernard R. Chaitman, Robert J. Temple, Heather D. Fitter, Kachikwu Illoh, Kenneth J. Cavanaugh, Benjamin M. Scirica, Ilan Irony, Rachel E. Brown Kichline, Jonathan G. Levine, Anna Park, Leonard Sacks, Ana Szarfman, Ellis F. Unger, Lori Ann Wachter, Bram Zuckerman, Yale Mitchel, Douglas Peddicord, Thomas Shook, Bron Kisler, Charles Jaffe, Rhonda Bartley, David L. DeMets, MariJo Mencini, Cheri Janning, Steve Bai, John Lawrence, Ralph B. D’Agostino, Stuart J. Pocock
Journal: Journal of the American College of Cardiology (2018)
P3.01-113 A Multicenter Survey of One Year Survival Among Chinese Patients with Advanced Nonsquamous Non-Small Cell Lung Cancer (CTONG1506)
Authors: P. Yu, Q. Zhou, Y. Song, X. Zhang, G. Chen, Y. Zhang, J. Chen, Z. Yu, Y. Hu, X. Song, D. Zhong, G. Feng, L. Yang, L. Zhan, L.D. Yao, Y. Chen, Y. Gao, Y. Wu
Journal: Journal of Thoracic Oncology (2018)
REPORT CXII. OBSERVATIONS ON THE PHYSIOLOGY OF THE FEMALE GENITAL ORGANS
Authors: W. B. Bell, P. Hick
Journal: BMJ (1909)

OUR work on menstruation.has for the most part been taken up with investigations into the relationship existing between this function and the calcium metabolism, and we have used in our deductions facts and 'observations which we demonstrated in connexion with the general calcium metabolism-alluded to in Paper I-as well as those which we now present as the result of our experi- CAlCt
Author's Name
Journal: JAMA (1977)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Psychopharmacological screening criteria development project
Authors: R. Dorsey
Journal: JAMA (1979)

PSYCHOTROPIC medications compose one of the largest classes of prescription drugs in the United States, and they are used extensively by psychiatrists and nonpsychiatric physicians.<sup>1,2</sup>For this reason alone, assurance of proper prescribing practices has major public health implications. In addition, the desires of government agencies to assess the performance of health care programs they fund or operate has led to the development of several sets of psychopharmacological criteria at the federal, state, and local levels.<sup>3-5</sup>To provide a uniform set of scientifically accurate, professionally acceptable model screening criteria useful on a nationwide basis, the National Institute of Mental Health contracted with the American Psychiatric Association (APA). A task force comprising expert psychopharmacologists developed criteria that have been approved by the Peer Review Committee of the APA as applicable to general psychiatric practice. Comments on these criteria were also sought from members of the Committee on Professional Standards
Indications for digitalis therapy. A new look
Authors: J. N. Cohn
Journal: JAMA (1974)

The indications for use of digitalis as an inotropic agent have been reexamined in the context of recent emphasis on the toxicity of digitalis and current knowledge regarding the mechanisms of clinical congestive heart failure in various disease states. Digitalis may be overprescribed in patients in whom (1) the signs and symptoms of congestive heart failure are not due primarily to an impairment of myocardial contractility, (2) administration of digitalis is not associated with notable improvement in cardiac function, or (3) increases in contractility could have a deleterious effect on myocardial metabolism. There must be increased selectivity in the administration of digitalis to patients with heart disease and more emphasis on pharmacologic manipulation of other factors that control cardiac performance. (<i>JAMA</i>229:1911-1914, 1974)
Adjuvant questions.
Authors: D Brinkley
Journal: BMJ (1984)

Adjuvant questionsTreatment fails to "cure" breast cancer in a high proportion of patients because the malignant cells disseminate throughout the body when the primary growth is small, and, though treat- ment for local and regional disease is effective using surgery and radiotherapy, there is no curative treatment for metastatic disease-and it is metastatic disease which kills.Long term follow up studies show that even in so called "early" disease
Ambivalence
Authors: Lester Stein
Journal: JAMA (1971)

<h3>To the Editor.—</h3> There seems to be a curious vendetta conducted by pediatricians who anathematize circumcision or tonsillectomy; by internists who delay surgery until the last drawn-out charade of "well, medicines won't help anymore;" by oculists who use every combination of miotics, inhibitors, and dehydrators before (with such infinite regret) referring to the necessity for surgical intervention for glaucoma; by optometrists who change spectacles many, many times, who use every kind of colored lenses, who suggest sleeping next to a colored light before oh, so regretfully admitting to a need for cataract extraction (since lenses will not help you anymore). Why all this ambivalence? What motivates those who quote the New Testament so cutely (<b>214</b>:2195, 1970) from the ivory tower of a pediatrics clinic to inveigh against a procedure which helps more males (and secondarily, females) than most others? As battalion surgeon, I had occasion to initiate surgical treatment
4R Program results: What is the impact of 4R care delivery model on patient self-management and which patients benefited?
Authors: Julia Rachel Trosman, Christine B. Weldon, Della F. Makower, Bruce D. Rapkin, Moreen Bozier, Claudia Beth Perez, Swati Kulkarni, Cathleen M. Schaeffer, Kent Hoskins, Christopher Gallagher, Shelly S. Lo, Cathy Grace-Louthen, Alyssa Throckmorton, Editha Krueger, Jennifer Van Horn, Arliene Ravelo, Elaine Yu, Lidia Schapira, Al Bowen Benson, William John Gradishar
Journal: Journal of Clinical Oncology (2020)

e19211 Background: We previously proposed a 4R model of teamwork and patient self-management (pSM) in cancer care (NCI ASCO Teams Project, Trosman JOP 2016). 4R (Right Info / Care / Patient / Time) enables patient and care team to manage complex care with an innovative 4R Care Sequence plan, including a novel visual feature describing timing and sequence of care. We report final results of a program which tested 4R at 5 safety net and 5 non safety net US centers from 2016 to 2019. Methods: Patients with stage 0-III breast cancer received 4R plans (4R Cohort). We surveyed 4R cohort and a historical control cohort of patients receiving care at same centers pre-4R. We assessed the usefulness of 4R to the 4R cohort and the impact on pSM in 4R cohort compared to historical cohort. Results: Survey response rates: 63%, 422/670 (4R cohort); 47%, 466/992 (control). 4R significantly increased the composite pSM score and 5 of 7 pSM metrics vs control (Table). The increase was not influenced by patient age, stage or whether treated at safety net site. pSM scores increased in 4R vs control cohort to a similar extent for patients &lt; 65 years old (74% vs 51%, p = .0001) as for patients ≥ 65 years old (78% vs 57%, p = .0002). pSM improved similarly for patients with stage 0 or I breast cancer (77% vs 56%, p = .0001) as for patients with stage II or III breast cancer (72% vs 54%, p = .0001). Safety net patients showed pSM increase (77% vs 51%, p = .0001) similar to non safety net patients (74% vs 58%, p = .0002). Within the 4R cohort, 80% found 4R useful for organizing care and 70% found the novel visual feature useful to manage care timing and sequence. Usefulness was similar for age groups and stages, but higher for safety net than non safety net patients (88% vs 74%, p = .0008). Conclusions: 4R markedly improved patient self-management in early breast cancer across age groups and cancer stages, but further enhancements are needed to benefit as many patients as possible. 4R benefits in safety net setting indicate that 4R may reduce disparities. [Table: see text]
THYROID TUMORS OF THE TONGUE.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Welcome to year 83
Authors: E. Friedman
Journal: JAMA (1995)

In this competitive society, Roger Evans, PhD, has written, the plight of the uninsured poor "reflects the unwillingness of our sociopolitical system to reward failure."<sup>1</sup>What, then, should be the response of health care folk to the failure of the sociopolitical system to protect the uninsured? One response—which is eagerly anticipated by some—is to fold the tents and go home. After all, more than 80% of the population (including most people who work in health care) have coverage,<sup>2</sup>although some of it (notably Medicaid) is threadbare on its good days, and little of it is reliable in the face of catastrophic disease or injury. Furthermore, is the battle not lost? Congress was unwilling even to pass reforms that would guarantee coverage (albeit at high cost) to those Americans whose health status makes it impossible for them to obtain private insurance, to protect 13 million uninsured children, or to
Epidemiology And Outcome Of Child Abuse
Authors: D. Rosenberg
Journal: Annual Review of Medicine (1991)

Maltreatment in childhood can result in problems that eventually present to the internist. The common somatic, psychosomatic, and psychiatric presentations in adults are reviewed. Mental health referral is often appropriate. When a case of child abuse is reported to the physician by a patient, the physician's legal responsibilities and protections are summarized.
Lettsomian Lectures ON JAUNDICE: WITH SPECIAL REFERENCE TO TYPES OCCURRING DURING THE WAR
Authors: W. H. Willcox
Journal: BMJ (1919)

Rui7,11At tlhirty-five of the autopsies blood-agar cultures from the liepatized lung were made.Colonies of influenza bacilli were obtained in 15 cases (43 per cent.),staphylococci in 19 cases (54 per cent.),streptococci in 19 cases (54 per cent.),pneumococoi in 2 cases (6 per cent.),M. tetragenus in 1 case (3 per cent.), and Gram-positive bacilli in 1 case.Influenza bacilli and staphylococci were obtained in 3 cases, influenza bacilli and strepto.cocci in 5 cases, influenza bacilli, staphylococci, and strepto- cocci in 2 cases, influenza bacilli, staphiylococci, and pneumo- cocci in 1 case, staphylococci and streptococci in 8 cases, streptococci and M. tertragenus in 1 case.In one case no growth was obtained.The blood-agai-medium was made by adding to peptone meat extract agar (previously melted at 1000 C. and then cooled to 50°C. to 450 C.) 10 per cent. of a solution of blood (warmed to 40' C.).The latter solution was prepared by mixing 5 c.cm. of human blood, withdrawn from a vein, with 95 o.cm. of sterile 0.85 per-cent.sodium chloride solution, and then laking by the addition of 10 c.cm. of ether.Colonies of influenza bacilli were isolated by plating out." oire
A public health approach to Canada's opioid crisis
Authors: None The Lancet Public Health
Journal: The Lancet Public Health (2018)

An unprecedented public health crisis is confronting North America: a deadly drug overdose epidemic. Opioids (including prescription opioids and illegal opioids, such as heroin and illicitly manufactured fentanyl) are the main drivers of drug overdose deaths in the USA and Canada. The situation in the USA has been widely publicised in international media outlets. Opioids were responsible for more than 42 000 deaths in 2016 in the USA, a number five times higher than in 1999. The situation in Canada is equally devastating.