tbuckley/cabot-search huggingface dataset:
Goggles: an adjunct to hospital infection control?
Authors: C. G. Ray
Journal: JAMA (1986)

Commencing sometime between early November and late March of each year, we see a rapid influx of patients with pneumonia or bronchiolitis into our pediatric inpatient units. This heralds the onset of respiratory syncytial virus (RSV) season, which invariably lasts from eight to 16 weeks. Our response is to curse the inevitable, enforce compulsive hand-washing procedures, tighten isolation and cohorting policies, and extend surveillance beyond patients to hospital staff with respiratory symptoms. We also attempt to restrict the flow of excessive numbers of visitors to pediatric and neonatal intensive care units and admonish our surgeons to postpone elective admissions of infants until the outbreak has subsided. Why must these frustrating logistical maneuvers occur every year? Because RSV is by far the most common cause of both community-acquired and nosocomially acquired severe lower respiratory tract disease in infants and young children.<sup>1</sup>Furthermore, the greatest threat is to hospitalized, infected infants
Abstract P5-04-12: Targeting of phosphatidylserine by monoclonal antibodies enhances activity of immune checkpoint inhibitors in breast tumors
Authors: Bruce Freimark, Jian Gong, Van Nguyen, Shen Yin, Rich Archer, Jeff Hutchins
Journal: Cancer Research (2015)

Abstract Phosphatidylserine (PS) is a phospholipid normally residing in the inner leaflet of the plasma membrane and becomes exposed on tumor vascular endothelial cells (ECs) and tumor cells. PS exposure becomes enhanced in response to chemotherapy, irradiation, and oxidative stresses in the tumor microenvironment. PS exposure in tumors promotes an immunosuppressive microenvironment which includes the recruitment of myeloid derived suppressor cells (MDSCs), immature dendritic cells, and M2-like macrophages as well as the production of anti-inflammatory cytokines. Binding of PS targeting antibodies on tumor endothelial cells, tumor cells and their secreted microparticles triggers an Fc-FcR mediated pro-inflammatory cellular and cytokine response that reverses the immunosuppressive PS meditated checkpoint, thereby enhancing anti-tumor immunity. A chimeric PS-targeting antibody, bavituximab, is being used in combination with chemotherapy to treat patients with solid tumors in multiple late-stage clinical trials. Using breast tumors in immune competent mice, we demonstrate PS targeting antibodies enhance the anti-tumor activity of anti-CTLA-4 and anti-PD-1 antibodies in the presence and absence of conventional chemotharapy. Tumor growth inhibition correlates with infiltration of immune cells in tumors and induction of adaptive immunity. The combination of these mechanisms promotes strong, localized, anti-tumor responses without the side-effects of systemic immune activation. Citation Format: Bruce Freimark, Jian Gong, Van Nguyen, Shen Yin, Rich Archer, Jeff Hutchins. Targeting of phosphatidylserine by monoclonal antibodies enhances activity of immune checkpoint inhibitors in breast tumors [abstract]. In: Proceedings of the Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2014 Dec 9-13; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2015;75(9 Suppl):Abstract nr P5-04-12.
Varicella Virus Vaccine Live Licensed: The FDA
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
VARIOLA AND VACCINIA.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pneumoperitoneum and right upper quadrant gas in a diabetic man
Authors: C. F. Butler
Journal: JAMA (1976)

<h3>History</h3> An 86-year-old man experienced anorexia and vomiting for three days. His previous health had been good. On examination, he was acutely ill and had scleral icterus, diffuse abdominal tenderness, and fever to 39 C. His total white blood cell count was 24,000/cu mm; blood glucose concentration, 600 mg/100 ml; and urine glucose, 4 +. Roentgenographic studies included a chest film and a spot film of the right upper quadrant of the abdomen (Fig 1 and 2). <h3>Diagnosis</h3> Emphysematous cholecystitis. <h3>Comment</h3> Chest roentgenogram (Fig 1) shows a right upper lobe infiltrate, air beneath the right hemidiaphragm, and a poorly depicted gas-fluid level in the gallbladder region. To clarify the gasfluid level, the abdominal film (Fig 2) was obtained. Gas outlines the major bile ducts (arrows) and gallbladder. After receiving antibiotics and fluids for one day, the patient successfully underwent removal of a distended gangrenous gallbladder, which contained foul-smelling pus and a
Interventions to Enhance Patient Adherence to Medication Prescriptions: Scientific Review—Correction
Authors: Peter Austin, Muhammad Mamdani, Karen Tu, Liisa Jaakkimainen
Journal: JAMA (2003)

last 2 quarters of 2002 was significantly lower than that predicted by the model (PϽ.001).The number of new users of ERT increased steadily until the publication of the HERS study, after which it began to decrease.However, the decline in the number of new users accelerated in the third quarter of 2002, with the number of new users in this quarter being significantly less than that predicted by the model (P=.02).Comment.In the 2 quarters following the publication of the WHI study, we found a large decline in both the prevalence of ERT use among elderly women and in the number of incident users of ERT.Although our study was limited to women older than 65 years, our data include all elderly women in Ontario.This limitation is also balanced by the fact that women aged 65 years or older are postmenopausal and thus unlikely to be taking ERT for symptom relief.Unfortunately, we were unable to determine whether the decline in use of ERT was physician-or patientinitiated.Nonetheless, we found that a well-publicized large clinical study may be associated with changes in medication prescription and use.
P1.04-02 Efficacy and Safety of Sintilimab with Anlotinib as First-Line Therapy for Advanced Non-Small Cell Lung Cancer (NSCLC)
Authors: B. Han, T. Chu, R. Zhong, H. Zhong, B. Zhang, W. Zhang, C. Shi, J. Qian, Y. Han
Journal: Journal of Thoracic Oncology (2019)
Predicting survival after hepatocellular carcinoma resection using deep-learning on histological slides
Authors: Charlie Saillard, Benoit Schmauch, Oumeima Laifa, Matahi Moarii, Sylvain Toldo, Mikhail Zaslavskiy, Elodie Pronier, Alexis Laurent, Giuliana Amaddeo, Helene Regnault, Daniele Sommacale, Marianne Ziol, Jean-Michel Pawlotsky, Sebastien Mulé, Alain Luciani, Gilles Wainrib, Thomas Clozel, Pierre Courtiol, Julien Calderaro
Journal: Journal of Hepatology (2020)
Chemical Groups of Oxytocin Correlated With Biological Activities
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Head-injured child with multiple fractures. Reexamined at skeletal maturity
Authors: J. C. Wilson
Journal: JAMA (1971)

Dr. Wilson: A 7-year-old girl was admitted to Children's Hospital of Los Angeles 23 days after having been struck down in the street by an automobile. Her injuries were a cerebral contusion, closed comminuted fracture of mid-shaft left femur, open fractures of the distal left radius and ulna, a posterosuperior dislocation of the right hip which was not immediately appreciated, intestinal contusions with gross melena, and contusions of both kidneys with hematuria. She had been admitted to a local hospital in coma where resuscitative measures were instituted immediately including tracheostomy, replacement of blood loss by transfusion, and splinting of fractures. Soon after admission, cranial bur holes were made bilaterally, but the patient's comatose state failed to improve significantly. Upon admission to Children's Hospital, the child was found to be semicomatose. Blood pressure was 150/60 mm Hg, pulse rate was 150 beats per minute, respirations were 25 per minute, and temperature
Polymyositis associated with AIDS retrovirus
Authors: M. C. Dalakas
Journal: JAMA (1986)

Two homosexual men were initially seen with polymyositis as the only manifestation of the acquired immunodeficiency syndrome (AIDS) retrovirus infection. They developed AIDS-related complex a few weeks later and typical AIDS two to six months after onset of muscle weakness. By use of anti-human T-cell lymphotropic virus type III antiserum and monoclonal antibodies to lymphocyte subsets in an immunofluorescence technique, viral antigens were found in the OKT4-positive lymphoid cells surrounding muscle fibers and invading the endomysia septa. We concluded that an initial infection with the AIDS retrovirus can be associated with polymyositis, which may be the first clinical manifestation of an impending AIDS-related complex or AIDS. (<i>JAMA</i>1986;256:2381-2383)
THE INFANTICIDE REVELATIONS.
Journal: JAMA (1889)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
JHEP at a glance (July 2019)
Authors: Sabrina Merat, Camille Bru, Dorien Van De Berg, Hergen Spits, Tim Beaumont, Janke Schinkel, Hui Feng, Anna-Lena Sander, Andrés Moreira-Soto, Daisuke Yamane, Jan Drexler, Stanley Lemon
Journal: Journal of Hepatology (2019)
Travel Notes.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Calcium Channel Antagonists and Gingival Hyperplasia
Authors: David E. Mathis
Journal: Annals of Internal Medicine (1994)

Letters15 October 1994Calcium Channel Antagonists and Gingival HyperplasiaDavid E. Mathis, MD and Allison P. Scheetz, MDDavid E. Mathis, MDSearch for more papers by this author and Allison P. Scheetz, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-121-8-199410150-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We read with interest the report by Steele and colleagues [1] on calcium antagonist-induced gingival hyperplasia. Recently, we found two young adults who experienced gingival hyperplasia while receiving high-dose, extended-release nifedipine. We are curious about several other issues not specifically addressed in the report. First, was the treatment drug given in several doses daily as standard release, or was the extended-release preparation used? If the extended-release methods were used, were plasma levels checked? Could the delivery system have affected the prevalence of hyperplasia? Second, how was drug compliance addressed? Was this a confounding issue? Third, were there ...REFERENCE1. Steele RM, Schuna AA, Schreiber RT. Calcium anatagonist-induced gingival hyperplasia. Ann Intern Med. 1994; 120:663-4. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 October 1994Volume 121, Issue 8Page: 624-625KeywordsAdverse reactionsBlood plasmaCalciumCalcium channel blockerDrugsRacial and ethnic issuesYoung adults Issue Published: 15 October 1994 CopyrightCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Current Radiology
Authors: Yolanda T. Adler
Journal: JAMA (1980)

Ever-increasing new developments in medicine make it a challenge to keep pace, and few, if any, physicians profess themselves to be satisfied with their ability to do so.<i>Current Radiology</i>addresses itself to this problem in a sensible manner. It is not intended to provide an exhausting review of the literature. Rather, a group of knowledgeable people summarize and comment on what they consider to have been important works published in the medical journals within the year. Although the contributors differ in style and in approach, it is evident that the editors have taken pains to see that chapters are consistently well organized. It is easy to open the book and locate quickly a specific entity. Most of the reviewers write in a slightly informal style, which makes the reading easy and rather entertaining. Of course, because of the necessity to be selective, the author's own interests and prejudices admittedly
Postnatal Effects of Maternal Exposure to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD)
Authors: J. A. Moore, B. N. Gupta, J. G. Zinkl, J. G. Vos
Journal: Environmental Health Perspectives (1973)

Previous studies reported that subcutaneous administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) at a dose level of 3 ,pg/kg, in mice on days 6 through 15 of ges- tation produced pups with cleft palates and kidney anomalies (1).The C57B1/6 mouse was the most sensitive of the three strains tested to the TCDD-induced kidney effects, in that almost 100%o of the fetuses developed kidney anomalies.The purpose of this pa- per is to report subsequent studies which attempt to characterize the teratogenic re- sponse as seen in the C57B1/6 mouse with specific emphasis on the nature and signifi- cance of the kidney anomaly.To distinguish between delayed kidney development, which if transient is of diminished significance, and irreversible effects, postnatal studies were also conducted.Reversible delays in metanephric kidney maturation in the rat have been described (2). Materials and MethodsInbred mice of the C57B1/6 strain were obtained from either the Jackson Laboratory, Bar Harbor, Maine, or the AR Schmidt Company, Madison, Wisconsin, and mated at the Institute.Detection of a vaginal plug indicated day 0 of pregnancy.All experimental mice were singly housed in plastic cages and allowed free access to food and water.
Abstract 4659: Cadmium induced malignant transformation involves activation of the Erk/MAPK pathway
Authors: Pritha Dasgupta, Priyanka Kulkarni, Nadeem S. Bhat, Ravi Gupta, Yutaka Hashimoto, Sharanjot Saini, Altaf A. Dar, Varahram Shahryari, Soichiro Yamamura, Yuichiro Tanaka, Marisa Shiina, Rajvir Dahiya, Shahana Majid
Journal: Cancer Research (2019)

Abstract Cadmium (Cd) is a chemical pollutant of the natural and occupational environment and is reported to be associated with human carcinogenesis. The molecular mechanisms associated with Cd-induced prostate cancer remain elusive. This study provides evidence that Erk/MAPK signaling is a carcinogenic molecular fingerprint for Cd induced prostate cancer. Cd exposed RWPE1 (Cd-RWPE1) cells robustly formed tumors in nude mice. Functionally, chronic Cd exposure of RWPE1 cells promoted cell survival, proliferation and colony formation with inhibition of apoptosis. RT2 PCR array analysis of 84 genes involved in the Erk/MAPK pathway revealed induction of gene expression in Cd-RWPE1 cells compared to RWPE1. This was confirmed by individual TaqMan gene expression analysis. Gene Set Enrichment Analysis (GSEA) for differentially expressed genes in Cd-RWPE1 showed an enrichment of the Erk/MAPK pathway along with other pathways such as KEGG-ERBB, KEGG-Cell Cycle, KEGG-VEGF, KEGG-Pathways in cancer and KEGG-prostate cancer pathway. We randomly selected upregulated genes from the Erk/MAPK pathway and performed profile analysis in a prostate adenocarcinoma data set (n=534) from the TCGA/GDC data base. We observed upregulation of these genes in prostate cancer compared to normal prostate samples. Taken together, these data reveal that Erk/MAPK signaling is a major pathway involved in Cd-induced malignant transformation of normal prostate epithelial cells. Understanding the dominant oncogenic pathways involved in the malignant transformation of normal prostate epithelial cells may help develop optimal therapeutic strategies for prostate cancer. Citation Format: Pritha Dasgupta, Priyanka Kulkarni, Nadeem S. Bhat, Ravi Gupta, Yutaka Hashimoto, Sharanjot Saini, Altaf A. Dar, Varahram Shahryari, Soichiro Yamamura, Yuichiro Tanaka, Marisa Shiina, Rajvir Dahiya, Shahana Majid. Cadmium induced malignant transformation involves activation of the Erk/MAPK pathway [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4659.
World Medical Association
Authors: N. W. Hoover
Journal: JAMA (1970)

Comprehensive health care, health delivery systems, community medicine—these are the contemporary idiom of medical rhetoric. We have now become greatly concerned with problems which are not new to us, but only newly recognized. In his recent book,<i>Health and the Developing World</i>, John Bryant<sup>1</sup>has paraphrased a universal problem: Every medical success must be measured against the needs of all. Every effort, every cluster of resources, must be divided by the total number of people. The insistence on using this denominator—all the people—has profound social, political, ethical, and educational implications. The United States has been protected by its affluence from the compelling voice of society, until now. We are lately dealing with matters which have forced the attention of other nations for a generation. We cannot afford to ignore their experience. The World Medical Association was formed in 1947 as a meeting place and common forum for physicians of
Infectious Syphilis of the Anal Canal
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal