The Effects of Aspirin on Gastric Prostaglandins
Authors: Makau Lee
Journal: Annals of Internal Medicine (1994)

Letters1 July 1994The Effects of Aspirin on Gastric ProstaglandinsMakau Lee, MD, PhD, Byron Cryer, MD, and Mark Feldman, MDMakau Lee, MD, PhDThe University of Texas Health Science Center; San Antonio, TX 78284-7878Veterans Affairs Medical Center; Dallas, TX 75216Search for more papers by this author, Byron Cryer, MDThe University of Texas Health Science Center; San Antonio, TX 78284-7878Veterans Affairs Medical Center; Dallas, TX 75216Search for more papers by this author, and Mark Feldman, MDThe University of Texas Health Science Center; San Antonio, TX 78284-7878Veterans Affairs Medical Center; Dallas, TX 75216Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-121-1-199407010-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We appreciate Dr. Jonas' thoughtful concerns. The single as yet unconfirmed report that aspirin at ultra-low doses (that is, 0.01 mg/d) may paradoxically reduce bleeding time slightly and transiently without affecting platelet aggregation is interesting [1]. However, this is 1/300th of the lowest dose we studied (3 mg/d) and 1/32 500th of the conventionally recommended aspirin dose for cardiovascular prophylaxis (325 mg/d). Our intent was to determine the threshold dose of gastroduodenal mucosal prostaglandin inhibition in humans because aspirin doses below this threshold may selectively inhibit thromboxane-dependent platelet functions without injuring the gastric mucosa [2]. Our data suggest ...References1. Doutremepuich C, de Seze O, LeRoy D, Lelanne MC, Anne MC. Aspirin at very ultra low dosage in healthy volunteers: effects on bleeding time, platelet aggregation and coagulation. Haemostasis. 1990; 20:99-105. Google Scholar2. Lee M, Cryer B, Feldman M. Dose effects of aspirin on gastric prostaglandins and stomach mucosal injury. Ann Intern Med. 1994; 120:184-9. Google Scholar3. Kallmann R, Nieuwenhuis HK, de Groot PG, van Gijn J, Sixma JJ. Effects of low doses of aspirin, 10 mg and 30 mg daily, on bleeding time, thromboxane production and 6-keto-PGF1-α excretion in healthy subjects. Thromb Res. 1987; 45:355-61. Google Scholar4. Fitzgerald GA, Oates JA, Hawiger J, Maas RL, Roberts LJ, Lawson JA, et al. Endogenous biosynthesis of prostacyclin and thromboxane and platelet function during chronic administration of aspirin in man. J Clin Invest. 1983; 71:676-88. Google Scholar5. Buchanan MR, Rischke JA, Butt R, Turpie AG, Hirsh J, Rosenfeld J. The sex-related differences in aspirin pharmacokinetics in rabbits and man and its relationship to antiplatelet effects. Thromb Res. 1983; 29:125-39. Google Scholar Author, Article, and Disclosure InformationAffiliations: The University of Texas Health Science Center; San Antonio, TX 78284-7878Veterans Affairs Medical Center; Dallas, TX 75216 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1994Volume 121, Issue 1Page: 72KeywordsAspirinHemorrhagePharmacokineticsPlatelet aggregationPlateletsProphylaxisProspective studiesProstaglandinsStomachThromboxane Issue Published: 1 July 1994 CopyrightCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...