tbuckley/cabot-search huggingface dataset:
TUBERCLE BACILLI IN THE BREAST MILK OF A TUBERCULAR WOMAN.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Veterans’ Benefits
Authors: Mike Mitka
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Contraceptive vaccine research: still an art
Journal: JAMA (1980)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 633: Suppression Of Mitochondrial GSK3β Activity By Its Ser9-phosphorylation Contributes To Cardiomyocyte Protection Afforded By Erythropoietin Against Oxidative Stress-induced Apoptosis
Authors: Katsuhiko Ohori, Tetsuji Miura, Masaya Tanno, Takayuki Miki, Takahiro Satoh, Yoshiyuki Horio, Kazuaki Shimamoto
Journal: Circulation (2007)

Objective Activation of the erythropoietin (EPO) receptor induces phosphorylation of numerous protein kinases, including glycogen synthase kinase 3β (GSK3β), and affords myocardial protection against ischemia/reperfusion injury. However, contribution of GSK3β to EPO-induced protection against apoptosis has not been directly demonstrated. Here, we examined whether alterations in activity and/or localization of GSK3β are critically involved in EPO-induced protection against oxidant stress-induced apoptosis. Methods and Results Apoptosis was induced in H9c2 cardiomyocyte by H 2 O 2 (50 μM) or angiotensin II (150 μM). Pretreatment with EPO (10 U/ml) suppressed H 2 O 2 -induced apoptosis (26.0± 2.7% vs. 38.3±2.9%, p&lt;0.05) and also angiotensin II-induced apoptosis (21.5±0.9% vs. 31.9±1.4%, p&lt;0.05) compared with that in untreated controls. Next, to examine the role of Ser9-phosphorylation of GSK3β, which suppresses GSK3β activity, H9c2 cells were transfected with EGFP-tagged wild-type (WT), constitutively active (S9A) or dominant negative (K85R) GSK3β. Apoptosis by H 2 O 2 was increased in S9A-transfected cells compared with that in WT-transfected cells (44.4±5.7% vs. 30.6±2.1%, p&lt;0.05) and decreased in K85R-transfected cells (26.1±4.3%). EPO suppressed apoptosis in WT-transfected cells (21.9±2.5% vs. 30.6±2.1%, p&lt;0.05) but not in S9A- or K85R-transfected cells. The effect of EPO was mimicked by suppression of GSK3β expression by its siRNA. Finally, to examine the effects of EPO on intracellular localization of GSK3β, H9c2 cells were transfected with WT and mitochondria were stained with MitoTracker. EPO did not change % of total GSK3β cololcalized with mitochondria but increased phospho-GSK3β colocalized with mitochondria by 55%. Conclusion: Together with reported inhibition of mitochondrial permeability transition by phospho-GSK3β, the present results suggest that suppression of GSK3β activity by its Ser9-phosphorylation in mitochondria plays a crucial role in cardiomyocyte protection by EPO against oxidant stress-induced apoptosis.
The Cover
Authors: Donald J. Dalessio
Journal: JAMA (1983)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Vascular Expression of Polycystin-2
Authors: VICENTE E. TORRES, YIQUIANG CAI, XI CHEN, GUANQUING Q. WU, LIN GENG, KATHLEEN A. CLEGHORN, CHRISTOPHER M. JOHNSON, STEFAN SOMLO
Journal: Journal of the American Society of Nephrology (2001)

Abstract. The expression of polycystin-1 in the vascular smooth muscle cells (VSMC) of elastic and large distributive arteries suggests that some vascular manifestations of autosomal-dominant polycystic kidney disease (ADPKD) result directly from the genetic defect. Intracranial aneurysms have been reported in PKD2 , as well as in PKD1 families. To determine whether the vascular expression of polycystin-2 is similar to that of polycystin-1, the expression of PKD2 mRNA and protein in cultured pig aortic VSMC was studied and immunofluorescence and immunohistochemistry were used to study the localization of polycystin-2 in cultured pig aortic VSMC, pig ascending thoracic aorta, and normal elastic and intracranial arteries and intracranial aneurysms obtained at autopsy from patients without or with ADPKD. Tissues derived from Pkd2 wild-type and Pkd2 null mice were used to confirm the specificity of the immunostaining for polycystin-2. Northern blots of VSMC revealed the expected 5.3-kb band. Western blotting detected a 110-kb band in a 100,000 × g fraction of VSMC homogenates. Cultured VSMC as well as VSMC between the elastic lamellae of pig thoracic aorta were positive for polycystin-2 by immunofluorescence. The staining pattern was cytoplasmic. Treatment of the cells before fixation with Taxol, colchicine, or cytochalasin-D altered the pattern of staining in a way suggesting alignment with the cytoskeleton. The immunohistochemical staining for polycystin-2 was abolished by extraction with 0.5% Triton X-100, indicating that polycystin-2 is not associated with the cytoskeleton. Weak immunoreactivity for polycystin-2, which was markedly enhanced by protease digestion, was detected in formaldehydefixed normal human elastic and intracranial arteries. Immunostaining of variable intensity for polycystin-2, which was not consistently enhanced by protease digestion, was seen in the spindle-shaped cells of the wall of the intracranial aneurysms. The similar expression of polycystin-1 and polycystin-2 in the vascular smooth muscle is consistent with the proposed interaction of these proteins in a single pathway. These observations suggest a direct pathogenic role for PKD1 and PKD2 mutations in the vascular complications of ADPKD.
Anthelmintics. I.
Journal: BMJ (1970)

A patient with an acute paraplegia may develop gross distension of the bowel amounting to an ileus, presumably due to disturbance of its autonomic nerve supply.Gastric aspiration and intravenous fluids will then be necessary.Flatus may be relieved by the passage of a rectal tube.Constipation is a common feature of established paraplegia.If it does not re- spond to simple measures such as magnesia, liquid paraffin, and suppositories it may best be managed by a twice weekly colon washout or enema. Relief of Pain, Painful Spasms, and SpasticityPostoperative pain and pain due to local invasion of bone by malignant tumours is treated along the usual lines.After operations on the cervical spinal cord, however, it is wise to avoid morphine and its derivatives or substitutes because, immediately at least, depression of function of the phrenic out- flow in the mid-cervical region may jeopardize respiration.Codeine phosphate by injection (25-60 mg.) can safely be used in these cases.A particular problem in the management of severe spastic paraplegia is the occurrence of involuntary flexor or extensor spasms, which are often extremely painful.Much may be done to reduce their frequency and intensity by regular physio- therapy, by adequate rest and sedation, and by attention to any intercurrent infection in the bladder or elsewhere.There are no effective drugs available which will reduce these spasms nor the spasticity except the liberal use of morphine and its sub- stitutes.In certain cases this may be desirable for short periods and may tide the patient over a bad patch, while in advanced malignant disease it may be entirely justifiable ter-
Marginal Decrease in Mortality and Marked Increase in Incidence as a Result of Neuroblastoma Screening at 6 Months of Age: Cohort Study in Seven Prefectures in Japan
Authors: Keiko Yamamoto, Shigeru Ohta, Etsuro Ito, Yutaka Hayashi, Tadashi Asami, Osamu Mabuchi, Masamune Higashigawa, Masako Tanimura
Journal: Journal of Clinical Oncology (2002)

PURPOSE: To determine the usefulness of 6-month screening for neuroblastoma. PATIENTS AND METHODS: The cumulative incidence rates (IRs) and cumulative mortality rates (MRs) of neuroblastoma in children younger than 60 months of age were analyzed for control (n = 713,025), qualitative screening (Qual Screen, n = 1,142,519), and quantitative screening (Quan Screen, n = 550,331) cohorts, and for Screened and Unscreened subgroups within screening cohorts. RESULTS: IRs (per 100,000) for infants aged 6 to 11 months were 1.12 in Control, 5.69 in Qual Screen (P &lt; .0001), and 17.81 in Quan Screen (P &lt; .0001); IRs for children aged 12 to 59 months were 7.29 in Control, 5.86 in Qual Screen (P = .28), and 6.36 in Quan Screen (P = .60). IRs for children aged 12 to 59 months in Unscreened or Screened subgroups remained at the same level. When patients diagnosed at younger than 6 months of age were excluded, the MR (per 100,000) under 60 months for Control was 4.21; those in Unscreened and Screened subgroups were 3.84 and 2.53 in Qual Screen (P = .30), and 3.20 and 1.97 in Quan Screen (P = .73), respectively; MRs between Control and Unscreened subgroups revealed no significant differences (P = .89 in Qual Screen, P = .85 in Quan Screen). CONCLUSION: Six-month screening resulted in a marked increase in incidence for infants with no significant decrease in incidence for children older than 1 year of age. A decrease in mortality was observed, but it was not significant. The usefulness of screening is questionable, because the decrease of mortality should be balanced against the adverse effect of overdiagnosis and the psychological burden on parents and children.
Aspirin and migraine: what about women?
Authors: H. Akama
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Limited form of Wegener granulomatosis. Eye involvement as a major sign
Authors: R. E. Coutu
Journal: JAMA (1975)

Bilateral uveitis was the initial manifestation of a limited form of Wegener granulomatosis in a 47-year-old man. Diagnosis was established by biopsy of a pulmonary nodule. Subsequently, evidence of lesions developed in the patient's central and peripheral nervous systems, but renal lesions were absent. Pulmonary lesions regressed on therapy with azathioprine and prednisone. Blindness ultimately resulted from retinal phlebitis, vitreous hemorrhages, and neovascular glaucoma. (<i>JAMA</i>233:868-871, 1975)
NCI and ORI Investigate Possible Data Falsifications
Journal: JNCI Journal of the National Cancer Institute (1994)

Journal Article NCI and ORI Investigate Possible Data Falsifications Get access JNCI: Journal of the National Cancer Institute, Volume 86, Issue 9, 4 May 1994, Pages 666–667, https://doi.org/10.1093/jnci/86.9.666-a Published: 04 May 1994
Postemetic rupture of herniated cardia of the stomach
Authors: G. J. Gallivan
Journal: JAMA (1982)

<h3>To the Editor.—</h3> Indeed, there is nothing new under the sun nor above the diaphragm. The article by Gapp et al (1982;247:811) indicated that isolated rupture through a herniated gastric cardia owing to forceful emesis had not been identified in their review of the literature. I have treated surgically a similar case in 1975. <h3>Report of a Case.—</h3> A 60-year-old woman had previously undergone a right transthoracic ligation of blebs with pleurodesis and a simultaneous modified Belsey repair of a symptomatic hiatal hernia. Three years later, she was seen for a three-day history of acute left submammary, retrosternal, and subscapular pleuritic chest pains, which were associated with vomiting of all ingested materials. Because of a history of phlebitis, she was treated with intravenous heparin sodium for three days for possible pulmonary emboli. She was subsequently treated with warfarin sodium, tetracycline, and intermittent positive-pressure breathing. A left pleural effusion was treated
FIDUCIARY RESPONSIBILITY.
Journal: JAMA (1890)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
"Hypo/Hyper" Confounded
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 2833: Magnetic Resonance Imaging Characterization of Peri-Infarct Zone Remodeling following Reperfused Myocardial Infarction
Authors: Karl H Schuleri, Marco Centola, Kris S Evers, Robert Evers, Joshua M Hare, Albert C Lardo
Journal: Circulation (2008)

Background: Clinical studies using delayed enhanced magnetic resonance imaging (de-MRI) suggest the peri-infarct zone (PIZ) contains a mixture of viable and non-viable myocytes and is associated with greater susceptibility to ventricular tachycardia induction and adverse cardiac outcomes. However, data characterizing the temporal formation and remodeling characteristics of the PIZ do not exist. We hypothesized that the PIZ undergoes spatial/temporal changes in parallel with structural ventricular remodeling following reperfused myocardial infarction (MI). Methods: Ten mini-pigs underwent coronary occlusion followed by reperfusion. Functional and de-MRI studies were performed prior and at five time points after MI induction. Custom signal density threshold algorithms based on the remote myocardium were applied to define the infarct core and PIZ region. Results: LVEDV increased from 34.7. ± 2.2 ml to 47.8± 3.0 ml (day 3 and week 12, respectively; p&lt;0.001). The size of infarct scar expanded by 14% and thinned by 56% from day3 to 12 weeks ( p =0.004 and p &lt;0.001, respectively). Though, there was no change in total scar volume (11.0±0.8 ml and 9.2±1.2 ml, day 3 and week 12, respectively; p =NS), the PIZ volume showed significant changes over 12 weeks (figure ) parallel to the structural remodeling of the left ventricle. After the initial post-MI edema subsided the PIZ decreased further by 54% from day 10 to week 12 ( p =0.04) Conclusions : The PIZ is dynamic and decreases in volume following reperfused MI. Remodeling characteristics of the PIZ may provide mechanistic insights into the development of life-threatening arrhythmias and sudden cardiac death post-MI.
Influenza
Authors: E. D. Kilbourne
Journal: JAMA (1973)

Depending on the severity of its expression as disease, infection with influenza virus can be regarded as nuisance or plague. While most victims experience only brief, if incapacitating febrile illness related to viral replication in the upper respiratory tract and trachea, thousands die each year from the secondary bacterial pneumonias that follow such cytopathic effects, or, less commonly, from primary influenza virus pneumonia.<i>Influenza</i>by the late Professor Mulder and his long-time colleague and collaborator J. F. Ph. Hers, is restricted in its focus as an elegantly presented treatise and atlas of the pathology of fatal human influenza. The reader will search in vain for a clinical description or even a definition of the disease. The complicated epidemiology of this baffling illness is only briefly considered, and the remarkable advances in recent years in the understanding of its causative virus are unmentioned. All of this is regrettable, because Mulder, as
Apathetic thyrotoxicosis causing gastrointestinal malabsorption
Authors: T. W. Sheehy
Journal: JAMA (1974)

An insulin-dependent diabetic manifested striking malabsorption due to hyperperistalsis and rapid intestinal transit in the course of "apathetic" thyrotoxicosis. Simultaneously, she had amelioration of diabetes. Substitution of medium-chain triglycerides in the diet led to considerable reduction in both steatorrhea and fecal fluid loss. Appropriate therapy for thyrotoxicosis led to return of normal intestinal function and resurgence of diabetic symptoms. (<i>JAMA</i>230:69-71, 1974)