tbuckley/cabot-search huggingface dataset:
Observations on the Treatment of Pernicious Anaemia Based on a Study of its Causation with Notes of a Case
Authors: W. Hunter
Journal: BMJ (1890)

THE BRITISHI MEDICAL JOURNAL.8 margin of the fossa.The margins of the lon,itudinal fissure of the train were pretty firmly adherent in the anterior half, and the tips of the frontal lobes were adherent to the dura mater.There were evident signs of old meningitis at the base.The pia arachnoid was thickened and opaque, especially over the optic nerves, chiasma and tracts, the crura and pons.The optic nerves were dull grey, and the chiasma and tracts distinctly changed in colour.There was no marked diminution in size.The left third nerve was greyer than the right, and more flattened.The corpora quadrigemina were normal in size and appearance."Scattered tubercles were found in the brain.The fracture does not appear to have involved the optic foramen.A man aged about 30 was brought to me at St. Thomas's Hospital in 1888, complaining of loss of sight in the right eye.A few months previously he had been an inmate of the hospital suffering from concussion and an injury to the right frontal region (? frac- ture), but had not complained of his eyesight.Mr. Lawford reported atrophy of the disc, and the eye was quite blind.Mr. Nettleship16 says on the subject: "But in the more common cases the accident is an injury to the head, probably causing fracture of the roof of the optic canal, with crushing of and hamorrhage into the nerve, or perhaps occasionally tearing of the nerve on thile brain side of the canal.Both conditions have been shown to occur in fatal cases of fracture of the base of the skull."Another possible cause for blindness after these injuries is the occurrence of hbemorrhage into the sheaths of the optic nerves.In none of thepost-mortem recordc of cases in the series here brought forward was fracture in the neighbourhood of the optic foramen found, but in eight, where the damage to the base was severe, blood was found extravasated in the sheaths of the nerves.And in one at the end of eight days there was also slight neuritis.It is a remark- able fact, and one of considerable importance, that in these cases of injury to the head which I have ralated, and in which optic neur- itis was found on ophthalmoscopic examination, if the neuritis was found in both eyes complete recovery ensued, but if after an injury to the frontal region a condition of neuritis developed in one eye only, the disc presented at a later date complete atrophy, and the patient remained permanently blind on that side.Para- lysis of one or more branches of the third nerve may ensue as a
Sports-medicine in the world today
Authors: V. N. Smodlaka
Journal: JAMA (1968)

The first important attempt to form and define the area of sports medicine was made in Dresden, Germany, in 1911 at the World Hygienic Exposition, with a special department for hygiene of physical exercise. This exposition was the first reflection of the concepts of physicians from central Europe dealing with medical and hygienic problems in physical exercise, education, and sports. In 1913, a meeting of French physicians was held in Paris. The discussion covered the physiology and kinesiology of physical exercise. The French have since attributed great importance to this meeting by calling it the First Congress of Sports Medicine. World War I brought these activities to a standstill for many years. Finally, during the winter Olympics of 1928, in St. Moritz, Switzerland, Dr. Knoll of Switzerland and Dr. Latarjet of France took the initiative to call a meeting of 32 Olympic team physicians. This meeting established a committee with
True electro-anatomical mapping achieved by the simultaneous use of a right atrial basket catheter and 3D intracardiac echocardiography Ron D. B. Simon, Reza Razavi, Marc Miguel, Artur Baszko, Edward J. Baker, Jaswinder S. Gill. Guy's and St Thomas' Hospitals, London, United Kingdom
Journal: Journal of the American College of Cardiology (2001)
Criteria for hospitalizing children who have ingested products containing hydrocarbons
Authors: N. Anas
Journal: JAMA (1981)

The clinical records of 950 children who ingested products containing hydrocarbons were reviewed. Eight hundred children were asymptomatic at the time of the initial evaluation and remained so during a six- to eight-hour period of observation. All had normal chest films, and all were treated as outpatients. One hundred fifty other children were admitted to the hospital; 79 were symptomatic at the time of initial medical evaluation and had abnormal chest roentgenograms. Seventy-one other children were asymptomatic but had roentgenographic evidence of pulmonary involvement (36) or had had pulmonary symptoms before arriving at the medical facility (35). Complications (seven) occurred only in symptomatic children who had roentgenographic evidence of pneumonia. These data suggest that the majority of children who are brought for medical evaluation after ingesting hydrocarbon-containing substances do not experience pulmonary complications and therefore do not require hospitalization. Only children who are symptomatic at the time of initial medical evaluation or who became symptomatic during a six- to eight-hour observation period require hospitalization. (<i>JAMA</i>1981;246:840-843)
Nivolumab Doubles Survival for Patients with HNSCC
Journal: Cancer Discovery (2016)

Abstract In patients with head and neck squamous cell carcinoma refractory to platinum-based chemotherapy, those treated with nivolumab had a 30% reduction in the risk of death compared with those assigned to receive one of three single-agent chemotherapies, according to a recent phase III trial. In addition, 1-year survival among nivolumab recipients was double that of those who received a chemotherapeutic, the current standard of care.
Abstract P4-06-11: Expression of genes spanning a breast cancer susceptibility locus on 6q25.1 is modulated by epigenetic modification
Authors: AK Dunbier, J White, S Van Huffel
Journal: Cancer Research (2012)

Abstract Background: Genome wide association studies have identified single nucleotide polymorphisms around C6ORF97, an open reading frame (ORF) immediately upstream of the gene encoding ERα (ESR1) on 6q25.1, to be associated with increased risk of breast cancer1,2. C6ORF97 and two neighbouring genes, RMND1 and C6ORF211, are also co-expressed with ESR1 in oestrogen receptor positive (ER+ve) breast cancers and C6ORF97 expression is inversely associated with proliferation and recurrence free survival in a tamoxifen-treated patient cohort3. Epigenetic modification represents one potential mechanism through which expression of co-localised genes could be modulated. Aim: To investigate the role of epigenetic modification in the co-expression of ESR1, RMND1, C6ORF211 and C6ORF97. Methods: Methylation status and expression of genes in the ESR1/C6ORFs locus was assessed in postmenopausal breast cancers and ER+ve cell lines. Two ER+ve cell lines, MCF7 and T47D, were cultured in oestrogen-depleted media and samples were taken fortnightly for 6 months. DNA and RNA from ER+ve tumours was also analysed in addition to control ER-ve cell lines. Methylation analysis of CpG Islands within the ESR1/C6ORFs locus was carried out using methylation sensitive sequencing analysis. Expression levels of ESR1, RMND1, C6ORF211 and C6ORF97 were determined using quantitative real-time PCR. Results: Variation in methylation patterns was observed at a number of key CpG islands in the ESR1/C6ORFs region. ER+ve cell lines and highly ER+ve tumours were hypomethylated. Hypomethylation was associated with increased expression of ESR1, RMND1, C6ORF211 and C6ORF97. Temporal changes in methylation and expression of these genes were also observed over the period of oestrogen deprivation in both MCF7 and T47D. Conclusions: Methylation at the ESR1/C6ORFs locus is associated with expression levels of ESR1, RMND1, C6ORF211 and C6ORF97. This suggests that methylation is involved in modulating the expression of these four genes and that it could partially explain the previously observed co-expression of the genes. Our finding that hypomethylation in this region occurs in tumours with high ERα expression suggests that it could be a mechanism through which tumours increase ERα levels to maximise growth stimulation from oestradiol. Our observation that RMND1, C6ORF211 and C6ORF97 also increase in expression suggests that the proteins encoded by these genes may contribute to the phenotype exhibited by ER+ve breast tumours. References: 1. Turnbull C et al. Nature Genetics 2010;42:504–7. 2. Zheng W et al. Nature Genetics 2009;41:324–8. 3. Dunbier A et al. PLoS Genetics 2011;7:e1001382. Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P4-06-11.
Access to health care for the uninsured. The perspective of the American Academy of Family Physicians
Authors: G. F. Aukerman
Journal: JAMA (1991)

INCREASINGLY concerned about the plight of the 37 million uninsured Americans, the American Academy of Family Physicians (AAFP) calls for Congress to enact legislation greatly expanding access to health insurance coverage through a plan that builds on the current private and public sector programs. While acknowledging that the present system is imperfect, the AAFP believes that the immediate concern is to provide access to health care for the uninsured while, at the same time, working toward reform of the US health care system. The AAFP plan would require employers to offer coverage to full-time workers and their dependents, substantially revise and expand the Medicaid program, and include a Medicaid buy-in for those without employer-based insurance. The total increase over current spending to implement the AAFP proposal is estimated at $18.3 billion, exclusive of administrative costs. During the past 2 years the problem of the approximately 31 to 37 million Americans
JAMA 75 YEARS AGO
Journal: JAMA (1982)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
COUNCIL ON OCCUPATIONAL HEALTH
Journal: JAMA (1960)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Skin: Its Care and Treatment.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Worker Exposure to Vinyl Chloride and Poly(Vinyl Chloride)
Authors: James H. Jones
Journal: Environmental Health Perspectives (1981)

The National Institute for Occupational Safety and Health (NIOSH) in early 1974 began industrial hygiene studies of vinyl chloride exposed workers. Three VC monomer plants, three VC polymerization plants, and seven PVC fabrication plants were surveyed. V polymerization plant workers and workers in one job category in VC monomer plants were exposed to average levels above 1 ppm. The highest average exposure was 22 ppm. NIOSH health hazard evaluation studies since these initial surveys have primarily shown nondetectable levels of vinyl chloride. A NIOSH control technology study in 1977 showed that exposure levels in VC polymerization plants had been drastically reduced but exposure levels above 1 ppm were still found in several cases.
Elevated urinary leukotriene E4 in chronic lung disease of extreme prematurity.
Authors: D Davidson, D Drafta, B A Wilkens
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

We determined if pulmonary peptidoleukotrienes contribute to the pathogenesis of chronic lung disease of extreme prematurity (CLD) by measuring urinary leukotriene E4 (uLTE4). Study patients had a birth weight < 1000 g and were about 28 d old when they were classified as normal control subjects (n = 8) or as having CLD (n = 26, abnormal chest X-ray, supplemental O2 requirement +/- ventilator). Urinary LTE4 levels were significantly elevated in CLD compared with the control group (288 +/- 92 versus 35 +/- 10 pg/mg creatinine, mean +/- SE, p < 0.05). Ventilator-dependent CLD patients, who required dexamethasone and had demonstrated uLTE4 levels above the normal range, needed significantly higher peak inspiratory pressures (20 +/- 1 cm H2O versus 15 +/- 1 cm H2O) than similar patients with uLTE4 in the normal range, and the former group had a significant reduction in uLTE4 in the first 5 d of dexamethasone therapy (626 +/- 198 to 451 +/- 176 pg/mg Cr) as ventilatory support was reduced. We conclude that peptidoleukotriene production is activated in patients with CLD (and no other detectable organ dysfunction) to pathophysiologic levels described in adults with acute asthma. Prospective studies focused on infants dependent on high levels of ventilatory support may provide insights into the role of leukotriene synthesis inhibitors or receptor antagonists in the treatment of CLD.
Destructive bone disease in early syphilis
Authors: W. E. Dismukes
Journal: JAMA (1976)

Although destructive bone disease is a well-known complication of tertiary syphilis, osteitis or osteomyelitis are not commonly recognized as complications of early (primary or secondary) syphilis. A patient with secondary syphilis characterized by generalized lymphadenopathy, perianal condyloma lata, and positive rapid plasma reagin (RPR) and fluorescent treponemal antibody-absorption (FTA-ABS) tests also complained of headache, right shoulder pain, and right anterior chest pain and swelling. Roentgenograms showed mottled osteolytic lesions consistent with previously described luetic bone disease. Biopsy confirmed the diagnosis of syphilitic osteomyelitis, and treatment with penicillin resulted in prompt resolution of symptoms. (<i>JAMA</i>236:2646-2648, 1976)
Selected New Books
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Home Care
Authors: Sharon A Levine, Jeremy Boal, Peter A Boling
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fetal Hydrocephalus
Authors: Maria Michejda
Journal: JAMA (1984)

The postnatal course of a form of infantile porencephaly under pressure in monkeys was evaluated by comparing brain development between animals that had received the hydrocephalic antenatal vent for intrauterine treatment and those that had not been treated antenatally. Brain development was assessed by computed tomographic scans. The studies showed asymmetric malformations and associated porencephalic lesions in infant monkeys not treated in utero, despite installation of a conventional postnatal ventriculoperitoneal shunt. In contrast, apparently normal development of brain tissue in infants given intrauterine therapy was observed. (<i>JAMA</i>1984;251:2548-2552)
Publisher's note
Journal: American Journal of Hematology (2007)

Welcome to an American Journal of Hematology that is changing and will continue to change in significant ways during 2007 and beyond.Starting with this issue, you will begin witnessing the emergence of a publication with an altered mission that we anticipate will translate into renewed vigor.We will maintain many traditions established by Dr. Ananda Prasad over 30 years, but also introduce and establish over time new features, content, and an expedited
Acute Fatty Liver of Pregnancy
Authors: Marshall M. Kaplan
Journal: New England Journal of Medicine (1985)

ACUTE fatty liver of pregnancy is a potentially fatal, uncommon disorder that may complicate the third trimester of pregnancy. If unrecognized or untreated, the disorder may progress to fulminant hepatic failure with jaundice, encephalopathy, disseminated intravascular coagulation, uncontrollable gastrointestinal and uterine bleeding, and death. Until the late 1970s the disease had a dismal prognosis, with fetal and maternal mortality rates as high as 85 per cent.1 , 2 Early recognition of the disorder, rapid termination of pregnancy once the diagnosis has been made, and intensive supportive treatment have brightened the outlook considerably. Fetal and maternal mortality rates are now as low as . . .
Society Proceedings
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Notes on Consumption
Authors: R. P. Cotton
Journal: BMJ (1873)

the inertion of a cannula open at the end could not fail to give rise?An artificial point appeared to be the only solution; and it seemed to me that cocoa-butter was possessed of a peculiar fitness for the purpose ; for this reason; for a hard dense substance, its dissolubility under moderate heat is, I believe, quite without parallel.Subjection to a temperature of 96 degs.dissolves such a portion of it as my purpose requires with curious rapidity-in as nearly as possible one minute.