Cytomegalovirus Mononucleosis
Authors: DAVID RIFKIND
Journal: Annals of Internal Medicine (1968)

Editorial Notes1 October 1968Cytomegalovirus MononucleosisDAVID RIFKIND, PH.D., M.D., F.A.C.P.DAVID RIFKIND, PH.D., M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-69-4-842 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCytomegalovirus infection, which is usually subclinical, occurs in approximately 6% of women during pregnancy (1) and may result in congenital infection in up to 1 to 2% of the newborn (1, 2). Only a minority of these newborn manifest the classical, acute, fatal cytomegalic inclusion disease with hepatosplenomegaly, hemolytic anemia, jaundice, thrombocytopenic purpura, and central nervous system damage. In others the infection produces various combinations of hepatoslpenomegaly, abnormal liver function tests, microscephaly, and mental and motor retardation (2, 3). The total frequency of disease after congenital infection and its ultimate course remain to be established.Postnatally acquired cytomegalovirus infection occurs...References1. HILDEBRANDT RJ, SEVER JL, MARGILETH AM, and CALLAGAN DA: Cytomegalovirus in the normal pregnant woman. Amer. J. Obstet. Gynec. 98: 1125, 1967. CrossrefMedlineGoogle Scholar2. STERN H: Isolation of cytomegalovirus and clinical manifestations of infection at different ages. Brit. Med. J. 1: 665, 1968. CrossrefMedlineGoogle Scholar3. WELLER TH and HANSHAW JB: Virologic and clinical observaitons on cytomegalic inclusion disease. New Eng. J. Med. 266: 1233, 1962. CrossrefMedlineGoogle Scholar4. STERN H and ELEK SD: The incidence of infection with cytomegalovirus in a normal population. A serological study in Greater London. J. Hyg. (Camb.) 63: 79, 1965. CrossrefMedlineGoogle Scholar5. HANSHAW JB, BETTS RF, SIMON G, and BOYNTON RC: Acquired cytomegalovirus infection: association with hepatomegaly and abnormal liver-function tests. New Eng. J. Med. 272: 602, 1965. CrossrefMedlineGoogle Scholar6. HANSHAW JB: Cytomegalovirus complement-fixing antibody in microcephaly. New Eng. J. Med. 275: 476, 1966. CrossrefMedlineGoogle Scholar7. KLEMOLA E and KÄÄRIÄINEN L: Cytomegalovirus as a possible cause of a disease resembling infectious mononucleosis. Brit. Med. J. 2: 1099, 1965. CrossrefMedlineGoogle Scholar8. KLEMOLA E, KÄÄRIÄINEN L, VON ESSEN R, HALTIA K, KOIVUNIEMI A, and VON BONSDORFF C: Further studies on cytomegalovirus mononucleosis in previously healthy individuals. Acta Med. Scand. 182: 311, 1967. CrossrefMedlineGoogle Scholar9. CARLSTRÖM G, ALDEN J, BELFRAGE S, HEDENSTRÖM G, HOLMBERG L, NORDBRING F, and STERNER G: Acquired cytomegalovirus infection. Brit. Med. J. 2: 521, 1968. CrossrefMedlineGoogle Scholar10. RÄSÄNEN V and SAIKKU P: Cytomegalovirus hepatitis. Lancet. 2: 772, 1967. CrossrefGoogle Scholar11. LAMB SG and STERN H: Cytomegalovirus mononucleosis with jaundice as presenting sign. Lancet. 2: 1003, 1966. CrossrefMedlineGoogle Scholar12. TOGHILL PJ, BAILEY ME, WILLIAMS R, ZEEGEN R, and BOWN R: Cytomegalovirus hepatitis in the adult. Lancet. 1: 1351, 1967. CrossrefMedlineGoogle Scholar13. KÄÄRIÄINEN L, KLEMOLA E, and PALOHEIMO J: Rise of cytomegalovirus antibodies in an in-fectious-mononucleosis-like syndrome after transfusion. Brit. Med. J. 1: 1270, 1966. CrossrefMedlineGoogle Scholar14. KÄÄRIÄINEN L, PALOHEIMO J, KLEMOLA E, MÄKELÄ T, and KOIVUNIEMI A: Cytomegalovirus—mononucleosis. Isolation of the virus and demonstration of subclinical infections after fresh blood transfusion in connection with open-heart surgery. Ann. Med. Exp. Fenn. 44: 297, 1966. MedlineGoogle Scholar15. HENLE G, HENLE W, and DIEHL V: Relation of Burkitt's tumor-associated herpes-type virus to infectious mononucleosis. Proc. Nat. Acad. Sci. USA 59: 94, 1968. CrossrefMedlineGoogle Scholar16. CANGIR A and SULLIVAN MP: The occurrence of cytomegalovirus infections in childhood leukemia. JAMA 195: 616, 1966. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DAVID RIFKIND, PH.D., M.D., F.A.C.P.Affiliations: Departments of Microbiology and Medicine University of Arizona College of Medicine Tucson, Ariz. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byComparative Aspects: Oncogenic Animal HerpesvirusesInfectious Mononucleosis 1 October 1968Volume 69, Issue 4Page: 842-843KeywordsAbnormal liver function testsCentral nervous systemCytomegalovirus infectionHemolytic anemiaHepatosplenomegalyInfectious diseasesPregnancy ePublished: 1 December 2008 Issue Published: 1 October 1968 PDF downloadLoading ...