tbuckley/cabot-search huggingface dataset:
OSTEOPATHY IN GREAT BRITAIN
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
127O Tumour mutational burden and immune infiltration as independent predictors of response to neoadjuvant immune checkpoint inhibition in early TNBC in GeparNuevo
Authors: T. Karn, C. Denkert, K.E. Weber, U. Holtrich, C. Hanusch, B.V. Sinn, B. Higgs, P. Jank, J. Huober, J-U. Blohmer, W.D. Schmitt, S. Wu, M. van Mackelenbergh, C. Schem, E. Stickeler, C. Jackisch, M. Untch, A. Schneeweiss, S. Loibl
Journal: Annals of Oncology (2020)
The physician and the legal system
Authors: H. C. Modlin
Journal: JAMA (1972)

Social systems theory provides a frame of reference for understanding interactions between physicians and lawyers. The legal system in any community has its unique boundaries, processing methods, concepts, vocabulary, and ethics, which vary markedly from those of the medical system. Like science, the law is skeptical and employs many procedures to control bias, misperception, self-interest, and skewed judgment. The physician who enters this alien system, for example, as an expert witness in court, must expect to be subjected to complex rules of conduct, the legal concept of truth, fragmentation of functions among many legal agencies and agents, and the adversary method of developing data.
NATO Advanced Study Institute on Physics and Technology of Hyperthermla
Journal: JNCI Journal of the National Cancer Institute (1986)

Journal Article NATO Advanced Study Institute on Physics and Technology of Hyperthermla Get access JNCI: Journal of the National Cancer Institute, Volume 76, Issue 3, March 1986, Page 555, https://doi.org/10.1093/jnci/76.3.555-d Published: 01 March 1986
Low-Level Radioactive Wastes
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE OXIDIZING FERMENTS OR OXYDASES.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A health questionnaire based on paper-and-pencil medium individualized and produced by computer. II. Testing and evaluation
Authors: M. J. Martin
Journal: JAMA (1969)

A computer-generated and computer-processed health questionnaire has been evaluated for patient acceptance and reliability of content. Various formats have been tested and it was concluded that a mark-sense paper-and-pencil questionnaire offered significant advantages over a cardsort questionnaire. Studies of administration techniques showed that administration by a specially trained clerk is advantageous.
OP0093 Low runx3 expression alters dendritic cell function in patients with systemic sclerosis and contributes to enhanced fibrosis
Authors: W. Marut, A. Affandi, J. Broen, L. Bossini-Castillo, A. Ottria, R. Tieland, L. van Bon, M. Rossato, L. de Kroon, J. van Roon, J. Martin, R. Lafyatis, T. Radstake
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Systemic sclerosis (SSc) is an autoimmune disease with unknown pathogenesis manifested by inflammation, vasculopathy, and fibrosis in skin and internal organs. The type I IFN signature found in SSc propelled us to study plasmacytoid dendritic cells (pDCs) in this disease. <h3>Objectives</h3> To identify candidate pathways underlying pDC aberrancies in SSc and to validate its function on pDC biology. <h3>Methods</h3> PCR-based transcription factor profiling and methylation status analyses, SNP genotyping by sequencing, and flow cytometry analysis were performed in pDCs from healthy controls or SSc patients. pDCs were also cultured under hypoxia and RUNX3 levels were determined. To study Runx3 function in DCs, <i>Itgax</i>-Cre:<i>Runx3</i><sup>f/f</sup> mice were used in an <i>in vitro</i> functional assays and bleomycin-induced SSc skin inflammation and fibrosis model. <h3>Results</h3> Transcription factor RUNX3 was significantly downregulated in SSc pDCs on RNA and protein levels. A higher methylation status of the <i>RUNX3</i> gene correlated with RUNX3 gene expression level and disease susceptibility. After sequencing of the RUNX3 promoter region, we identified a non-synonymous SNP rs6672420 associated with SSc and hypermethylation of <i>RUNX3</i>. Additionally, pDCs cultured in hypoxic conditions showed a significantly lower RUNX3 expression. Furthermore, mouse pDCs deficient of Runx3 showed enhanced expression of co-stimulatory molecules upon CpG stimulation. Finally, in SSc bleomycin model, mice with DC-specific deletion of Runx3 showed increased skin inflammation and fibrosis. <h3>Conclusions</h3> We found low RUNX3 expression in pDCs of SSc patients. The presence of a SNP and higher methylation status of RUNX3, and downregulation in hypoxic condition, suggest at least three pathways underlying the low RUNX3 expression observed in SSc pDCs. We demonstrate a detrimental role of RUNX3-ablated DCs in a mouse SSc model further underscoring the role of pDCs in this disease. Further research is warranted to explore the potential therapeutic effect of RUNX3 targeting in fibrotic disease. <h3>Disclosure of Interest</h3> None declared
The Physician's Visiting List for 1907. Fifty-sixth Year of its Publication.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A DEPARTMENT OF HEALTH
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE ETIOLOGY OF SCARLET FEVER
Authors: GEORGE F. DICK
Journal: JAMA (1924)

Owing to the constancy with which hemolytic streptococci of one kind or another have been found associated with scarlet fever, they have long been considered as a possible cause of the disease. Attempts to prove their causal relation have encountered many obstacles, chief of which has been the failure to produce experimental scarlet fever. <h3>TYPES OF STREPTOCOCCI</h3> The hemolytic streptococci associated with scarlet fever do not all show the same cultural characteristics. They may be divided into two groups according to their effect on mannite. In a series of 100 cases studied in 1922 and 1923, hemolytic streptococci were found in all; 16 per cent. of these strains fermented mannite, and 84 per cent, did not ferment mannite. In 1923, we<sup>1</sup>reported experimental scarlet fever produced with one of the strains that fermented mannite. This strain was isolated from a case of scarlet fever. It produced experimental scarlet fever.
Further Evidence for a Humoral Natriuretic Factor
Authors: WILLIAM B. BLYTHE, DOMINGOS D'AVILA, HILLEL J. GITELMAN, LOUIS G. WELT, LING LEE
Journal: Circulation Research (1971)

Experiments were performed in dogs, utilizing cross-circulation techniques, to examine the role of humoral factors in the production of the diminished net renal tubular reabsorption of sodium that is provoked by the expansion of the extracellular fluid volume. When the extracellular fluid volume of one of a pair of dogs (donor) was expanded by the intravenous infusion of isotonic saline, the rate of sodium excretion (U Na V) increased in the nonexpanded animal (recipient) as well as in the donor. Although the increase in U Na V of the recipients was statistically significant, its magnitude was approximately one-fifth of that of the donors. Modified cross-circulation experiments were designed in order to increase the blood flow from the donor dog to the kidneys of the recipient and from the recipient dog to the kidneys of the donor. This modification resulted in a greater increase in U Na V in the recipient and a lesser increase in U Na V in the donor when the donor was infused intravenously with isotonic saline so that the magnitudes of increase in U Na V in donor and recipient were not statistically significantly different. Neither dilution per se of the extracellular fluid of the donor nor passage of time resulted in an increased U Na V in donors and recipients. Expansion of the blood volume of the donors by the infusion of whole blood resulted in an increased U Na V in the donors but not in the recipients. It is concluded that a humoral factor is responsible, at least in part, for the natriuresis that accompanies the intravenous infusion of isotonic saline and that elaboration of the factor is not a consequence solely of either simple dilution of the extracellular fluid or expansion of the blood volume.
Immunity to Diphtheria and Tetanus in the United States
Journal: Annals of Internal Medicine (2002)

Summaries for Patients7 May 2002Immunity to Diphtheria and Tetanus in the United StatesSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-136-9-200205070-00003 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?It is standard practice in the United States to vaccinate babies against diphtheria, tetanus, and whooping cough during the first year of life and to give booster shots at 15 to 18 months and 4 to 6 years. Ninety-five percent of children in the United States receive at least three doses of the vaccine by age 35 months. Revaccination against diphtheria and tetanus is performed less frequently than recommended by the U.S. Advisory Committee on Immunization Practices (ACIP). Although diphtheria infections and tetanus are rare in the United ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Serologic Immunity to Diphtheria and Tetanus in the United States.” It is in the 7 May 2002 issue of Annals of Internal Medicine (volume 136, pages 660-666). The authors are GM McQuillan, D Kruszon-Moran, A Deforest, SY Chu, and M Wharton.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoSerologic Immunity to Diphtheria and Tetanus in the United States Geraldine M. McQuillan , Deanna Kruszon-Moran , Adamadia Deforest , Susan Y. Chu , and Melinda Wharton Metrics 7 May 2002Volume 136, Issue 9Page: I-30KeywordsArmed forcesBloodDiphtheriaHealth surveysImmunityNutritionQuestionnairesRacial and ethnic issuesTetanusVaccines ePublished: 7 May 2002 Issue Published: 7 May 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Historians strive to improve perspective, practice of medicine
Authors: T. Ziporyn
Journal: JAMA (1985)

Every so often, an article on the history of medicine will appear in a medical journal. "The Story of Famous Doctor X." "How So-and-So Discovered Such-and-Such." "Medical Practice in Ancient Land Y." One busy practitioner may gratefully skip such articles, while another may skim them. Now and then, however, it may cross a reader's mind: Why should I be interested in medical history? And why in the world would anyone spend time studying Galen's view of the circulatory system? The authors of these histories of medicine will quickly jump to answer. Some will say they study the history of medicine to inspire themselves or others about the medical profession; conversely, some use their studies to engender humility about today's ephemeral theories. Others are trying to rediscover ideas useful to modern practice or investigation, to broaden general knowledge, or to put into context modern medical theories and events—perhaps to influence science
Manual of Psychiatry.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CYSTICERCUS OF THE FOURTH VENTRICLE.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction: European Society of Gastrointestinal Endoscopy (ESGE) curricula development for postgraduate training in advanced endoscopic procedures: rationale and methodology
Authors: Raf Bisschops, Evelien Dekker, James E. East, Gavin Johnson, Pedro Pimentel-Nunes, David S. Sanders, Mario Dinis-Ribeiro, Thierry Ponchon
Journal: Endoscopy (2019)

Correction to: European Society of Gastrointestinal Endoscopy (ESGE) curricula development for postgraduate training in advanced endoscopic procedures: rationale and methodologyEndoscopy 2019; 51(10): 976-979DOI: 10.1055/a-1000-5603
Design and analysis of studies of the health effects of ozone
Authors: A Muñoz
Journal: Environmental Health Perspectives (1993)

The design and analysis of studies that investigate the effect of exposure to ozone on health outcomes need to define carefully the methods for the assessment of the exposure and to determine precisely which is the outcome of biological relevance.The estimation of sample size for longitudinal studies requires the expected rates of change among the exposed and unexposed, the variance of the outcome, and the correlation of measure- ments taken within an individual.Methods of analysis whose primary interest is in the combination of cross-sectional studies for the determination of the marginal distribution of the outcome are particularly appropriate for biological processes where the effect of exposure is acute.Conditional models are particularly useful for investigating the effect of changes in exposure on changes in outcome at the individual level.In addition, condi- tional models incorporate a dampening effect of exposure that may provide a reasonable agreement with several biological mechanisms.The identi- fication of susceptible individuals and the description of the behavior of their outcomes over time may be better accomplished by using the within-individual variance as the outcome of interest.Discrepancies of the within-and between-individual regressions may be suggestive of chronic effects, and methodological research in this area is needed.Studies of the health effects of ozone exposure need to address the incorporation of missing data, measurement error, and the combination of complementary studies.
Sports Medicine
Authors: George A. Sheehan
Journal: JAMA (1971)

<h3>To the Editor.—</h3> My eight years of experience as a marathon runner compel me to give an unqualified "aye" to Fried and Shephard's plea for a team approach to sports medicine. It is my observation as an internist-distance runner that a key member of the team and often the last consulted (sometimes never consulted) is the podiatrist. Cures of long-standing leg and knee problems, frequently previously treated with steriod injection, have been observed with increasing frequency through the use of properly made shoe inserts. I know now of at least three documented cases of chondromalacia which cleared with corrective supports for foot problems. Unfortunately the podiatrists seem as unaware as the orthopedists of the potential musculoskeletal problems from overuse of weak feet. We have to get these men together.