tbuckley/cabot-search huggingface dataset:
Official Report
Authors: E.J. Anthony, G.W. Arendsen Hein, Dorothy W. Baruch, R. Battegay, Cornelius Beukenkamp, Åke Bjerstedt, Nathan Blackman, Curt Boenheim, Rachel B. Bross, Martha Brunner-Orne, José Angel Bustamante, Udo Derbolowsky, R.S. Drews, G. Egan, I. Frost, Henry Ezriel, C.M. Fleming, Hellmuth Freyberger, D. Fuchs-Kamp, H. Gastager, Henry Raphael Gold, Henry Greenbaum, S. Haddenbrock, Angela Hefferman, Thomas Hora, Asya L. Kadis, Berthold Kihn, F. Knobloch, D. Langen, Karl Hermann Lukas, Michael M. Miller, Theresa G. Muller, Jean Oury, Walter Zenner, Helmut Paul, Hertha Riese, Stefan de Schill, P.-B. Schneider, M. Barrelet, P. Jordi, R. Delaloye, Paul Senft, Gerdhild von Staabs, Mark Stern, Herbert Suchanek-Fröhlich, J. Wilder, Alexander Wolf, Emanuel K. Schwartz, Isidore Ziferstein, Manfred in der Beeck, Jack D. Krasner, G.A. Leutz, Margaret Naumburg, Janet Caldwell, Louis R. Ormont, G. Stürup, Ernst von Xylander
Journal: Psychotherapy and Psychosomatics (1959)
Noninvasive 24-hour ambulatory arterial blood pressure monitoring in cirrhosis*1
Authors: S MOLLER
Journal: Hepatology (1995)

Cirrhotic patients have disturbed systemic hemodynamics with reduced arterial blood pressure, but this has not been investigated during daily activity and sleep. Systolic (SBP), diastolic (DBP), and mean arterial blood pressure (MAP), and heart rate (HR) were measured by an automatic ambulant device for monitoring blood pressure in 35 patients with cirrhosis and 35 healthy matched controls. During the daytime, SBP, DBP, and MAP were significantly lower in the patients than in the controls (median 118 vs. 127; 70 vs. 78; 86 vs. 94 mm Hg, P < .0001 to P < .05). The nighttime blood pressures were almost similar in the two groups (108 vs. 110; 65 vs. 67; 78 vs. 82 mm Hg, NS). Conversely, HR was significantly higher in the patients both in the daytime (86 vs. 72/min, P < .0001) and at night (80 vs. 64/min, P < .0001). Consequently, the reduction in blood pressure and HR from daytime to nighttime was significantly lower in the patients than in the controls (P < .0001 to P < .01). Multiple regression analysis showed HR, serumalbumin, serum sodium, and clotting factors 2, 7, and 10 as significant independent predictors of SBP in cirrhosis. In conclusion, cirrhotic patients have elevated HR, but surprisingly normal arterial blood pressure during the nighttime, and the circadian variation in blood pressure and HR is diminished, probably because of an almost unaltered cardiac output during the 24 hours. These results may reflect a major defect in the ability of optimal regulation of blood pressure in cirrhotic patients.
Clarification for Reported Colposcopy Rates
Authors: Idris Evans, Derek Angus, Christopher Seymour
Journal: JAMA (2018)

Gina Suzanne Ogilvie, MD, FCFP, DrPH; Dirk van Niekerk, MB, ChB, Mmed, FFPath, LMCC, FRCPC; Mel Krajden, MD, FRCPC; Laurie W. Smith, RN, BN, MPH; Darrel Cook, MSc; Lovedeep Gondara, MS; Kathy Ceballos, MD; David Quinlan, MD, FRCSC; Marette Lee, MD, FRCSC, MPH; Ruth Elwood Martin, MD, FCFP, MPH; Laura Gentile, MHA; Stuart Peacock, DPhil; Gavin C. E. Stuart, MD, FRCSC; Eduardo L. Franco, DrPH, FRSC, FCAHS, OC; Andrew J. Coldman, PhD
THE CUTANEOUS TUBERCULIN REACTION.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Computed tomography for the evaluation of thoracic masses in children
Authors: S. B. Shurin
Journal: JAMA (1981)

Large chest masses in two young children were evaluated using thoracic computed tomography (CT). Air was identified within the mass four days before it was visible on the plain roentgenograms in one patient. Rapid injection of contrast material with CT scanning demonstrated that the pulmonary blood flow passed through the mass, instead of being displaced by it, in the other child. Thus, both lesions were identified as originating in the pulmonary parenchyma rather than in the mediastinum. (<i>JAMA</i>1981;246:65-67)
Steinach II Operation for Prostatic Enlargement
Authors: T. Hunter
Journal: BMJ (1938)

Article abstract—we performed an open-label study testing the effects of GM1 ganglioside on 10 Parkinson9s disease (PD) patients. Patients received 1,000 mg of GM1 by IV infusion after the last of three baseline functional assessments. Patients then self-administered GM1 at a dose of 200 mg/d, by subcutaneous injection, for 18 weeks. Under these conditions, GM1 ganglioside proved to be safe and well tolerated. There were no serious adverse events and none of the patients developed elevated anti-GM1 antibody titers. Improvements on at least some functional measures were present in most patients, beginning after 4 to 8 weeks of GM1 treatment. When functional improvements occurred, they lasted for the duration of the study. These results suggest that GM1 ganglioside is well tolerated and may be a useful adjunct to the treatment of PD, and that a double-blind, placebo-controlled study is now warranted.
Risk of contrast-induced acute kidney injury in cirrhotic patients undergoing computed tomography: myth or reality?
Authors: Daniela Campion, Martina Rizzo, Paola Ponzo, Alessandro Risso, Ilaria Giovo, Felice Rizzi, Michele Roma, Alessandra Risso, Paola Caropreso, Gian Paolo Caviglia, Loredana Colla, Luigi Biancone, Aldo Manca, Giulio Mengozzi, Giorgio Maria Saracco, Carlo Alessandria
Journal: Journal of Hepatology (2020)
Development of Robotic Enhanced Endoscopic Surgery for the Treatment of Coronary Artery Disease
Authors: Utz Kappert, Jens Schneider, Romuald Cichon, Vassilios Gulielmos, Sems-Malte Tugtekin, Joachim Nicolai, Klaus Matschke, Stephan Schueler
Journal: Circulation (2001)

Background The introduction of robotic enhanced surgery demanded stepwise development of performed procedures on the basis of growing experience of the operating team. Methods and Results Between May 1999 and January 2001, this new wrist-enhanced instrumentation was used in 201 patients (156 men and 45 women, median age 64±10.5 years, left ventricular ejection fraction 68±12.4%). During the development of robotic enhanced CABG, the patients were divided into 3 groups. Group A (n=156) consisted of patients in whom the robotic system was used to harvesting the left or right internal mammary artery, or both, whereas the anastomoses were performed directly through a small chest incision. In group B (n=37), the harvest of the internal mammary arteries and the coronary anastomoses were performed totally endoscopically. In a third early group C, patient (n=8) were treated with robotic enhanced CABG via a median sternotomy already preoperatively planned, whereas gradual step-by-step application of robotic instrumentation and its feasibility were assessed. The survival rate was 99.4%. One patient (0.6%) died due to pneumonia on postoperative day 16. Conversion rate to median sternotomy was 5%. The left and right internal mammary artery conduits could be successfully harvested in 98% and 100%, respectively. The time of dissection of the left internal mammary artery could be significantly reduced alone by increasing experience. All patients were discharged from the hospital after a mean of 7 days. In 9 patients (4.5%), bleeding required reexploration. Conclusions The introduction of this new surgical tool enables the development of new endoscopic procedures. Our results gained during the development of robotic enhanced CABG motivate us to establish a set standard for the totally endoscopic treatment of patients with 1-vessel coronary artery disease.
Global atmospheric change: potential health effects of acid aerosol and oxidant gas mixtures.
Authors: J A Last
Journal: Environmental Health Perspectives (1991)

Inhalation toxicology experiments in whole animals have demonstrated a remarkable lack of toxicity of sulfuric acid in the form of respirable aerosols, especially in rats and nonhuman primates. Thus, much of the current experimental emphasis has shifted to the evaluation of the potential health effects of acid aerosols as components of mixtures. Rats have been concurrently exposed to mixtures of ozone or nitrogen dioxide with respirable-sized aerosols of sulfuric acid, ammonium sulfate, or sodium chloride, or to each pollutant individually. Their responses to such exposures have been evaluated by various quantitative biochemical analysis of lung tissue or wash fluids ("lavage fluid") or by quantitative morphological methods ("morphometry"). Such studies have mainly been performed in the acute time frame due to the inherent limitations of the most sensitive assays available and have generally involved exposures for 1 to 9 days, depending on the assays used. Good correlations were found between the most sensitive biochemical indicators of lung damage (protein content of lung lavage fluid or whole lung tissue and lung collagen synthesis rate) and the exposure concentration of oxidant gas present alone or in mixtures with acidic aerosols showing interactive effects. Synergistic interaction between ozone and sulfuric acid aerosol was demonstrated to occur at environmentally relevant concentrations of both pollutants by several of the analytical methods used in this study. Such interactions were demonstrated at concentrations of ozone as low as 0.12 ppm and of sulfuric acid aerosol at concentrations as low as 5 to 20 micrograms/m3.(ABSTRACT TRUNCATED AT 250 WORDS)
Organ Damage in Different Types of High Blood Pressure
Journal: Annals of Internal Medicine (1999)

Summaries for Patients19 October 1999Organ Damage in Different Types of High Blood PressureSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-131-8-199910190-00038 SectionsAboutFull Text ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?It is well known that blood pressure measurements can vary. Some people will have high blood pressure (hypertension) when they are in a doctor's office but normal blood pressure when measured in other settings. Doctors use the term “white coat hypertension” to describe this occurrence, since the blood pressure is only high when the patient sees the doctor and doctors often wear white coats when they see patients. It is also possible that a person could have normal blood pressures in the doctor's office but have high blood ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Cardiac and Arterial Target Organ Damage in Adults with Elevated Ambulatory and Normal Office Blood Pressure.” It is in the 19 October 1999 issue of Annals of Internal Medicine (volume 131, pages 564-572). The authors are J.E. Liu, M.J. Roman, R. Pini, J.E. Schwartz, T.G. Pickering, and R.B. Devereux.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoCardiac and Arterial Target Organ Damage in Adults with Elevated Ambulatory and Normal Office Blood Pressure Jennifer E. Liu , Mary J. Roman , Riccardo Pini , Joseph E. Schwartz , Thomas G. Pickering , and Richard B. Devereux Metrics 19 October 1999Volume 131, Issue 8Page: 564KeywordsBlood pressureBrainCardiovascular therapyCarotid arteriesHeartHypertensionMyocardiumPrimary hypertensionStrokeUltrasound imaging ePublished: 15 August 2000 Issue Published: 19 October 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.Loading ...
Software
Authors: James A. Kruse
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A rapid and strong DNA vaccine optimized by in vivo analysis of antigen expression
Authors: J. B. Haanen, A. Bins, A. Jorritsma, A. De Lang, M. Smits, T. Schumacher
Journal: Journal of Clinical Oncology (2004)

2597 Background: Although DNA vaccination seems to be a safe and a relatively efficient method to generate immunity, it is time consuming, as induction of immunity requires at least one month. This limitation is likely to reduce the usefulness of current DNA vaccines for immunization of humans against an acute infectious threat. Assessment of the kinetics of antigen expression in living mice demonstrated that DNA delivered to the skin results in a highly transient pulse of antigen expression. Methods: Based on this information we developed a novel intradermal DNA vaccination method, employing an intradermal DNA tattooing technique. Results: By short-interval 'DNA tattooing', very large cytotoxic T cell responses could be generated within 14 days, and these responses provided protection against an experimental tumor challenge. Conclusions: The strength and speed of this newly developed strategy should be beneficial in situations where immunity is needed on the shortest possible term. No significant financial relationships to disclose.
Drug Abuse Related to Prescribing Practices
Journal: JAMA (1982)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Allied health education
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Absence of angiotensin II type 1 receptor in bone marrow–derived cells is detrimental in the evolution of renal fibrosis
Authors: Masashi Nishida, Hidehiko Fujinaka, Taiji Matsusaka, James Price, Valentina Kon, Agnes B. Fogo, Jeffrey M. Davidson, MacRae F. Linton, Sergio Fazio, Toshio Homma, Hiroaki Yoshida, Iekuni Ichikawa
Journal: Journal of Clinical Investigation (2002)

We examined the in vivo function of the angiotensin II type 1 receptor (Agtr1) on macrophages in renal fibrosis. Fourteen days after the induction of unilateral ureteral obstruction (UUO), wild-type mice reconstituted with marrow lacking the Agtr1 gene (Agtr1–/–) developed more severe interstitial fibrosis with fewer interstitial macrophages than those in mice reconstituted with Agtr1+/+ marrow. These differences were not observed at day 5 of UUO. The expression of profibrotic genes — including TGF-β1, α1(I) collagen, and α1(III) collagen — was substantially higher in the obstructed kidneys of mice with Agtr1–/– marrow than in those with Agtr1+/+ marrow at day 14 but not at day 5 of UUO. Mice with Agtr1–/– marrow were characterized by reduced numbers of peripheral-blood monocytes and macrophage progenitors in bone marrow. In vivo assays revealed a significantly impaired phagocytic capability in Agtr1–/– macrophages. In vivo treatment of Agtr1+/+ mice with losartan reduced phagocytic capability of Agtr1+/+ macrophages to a level comparable to that of Agtr1–/– macrophages. Thus, during urinary tract obstruction, the Agtr1 on bone marrow–derived macrophages functions to preserve the renal parenchymal architecture, and this function depends in part on its modulatory effect on phagocytosis.
Abstract 3720: Blockade of the short-form of prolactin receptor induces FOXO3a/EIF-4EBP1-mediated cell death in uterine cancer
Authors: Yun-Fei Wen, Ying Wang, Shaolin Ma, Anca Chelari Raicu, Keith A. Baggerly, Anil K. Sood
Journal: Cancer Research (2019)

Abstract Purpose: Extra-pituitary prolactin (PRL) is involved in development and progression of uterine carcinoma. However, the underlying mechanisms of PRL/PRLR axis in uterine cancer are not well understood, and current means of targeting this axis are limited. Here, we used a potent PRL antagonist (G129R) to interfere with oncogenic activities of uterine cancer cells and further inhibit tumor growth. Experimental Design: We performed integrated analyses by comparing expression of PRLR isoforms in a broad panel of tumors and normal countparts using TCGA and GTex databases. Therapeutic effects of G129R treatment in uterine cancers were assessed in both orthotopic PTENwt and PTENmut models. Additionally, we carried out reverse phase protein assay (RPPA) at in vivo condition from the resulting tumors and at in vitro conditions to interrogate downstream targets and mechanism of action for G129R. Further functional analyses including cell viability, cell cycle and nascent protein synthesis were accessed in two types of uterine cancer cells under serum-depleted condition. Results: We found that PRLR_S1a, a short form of PRLR that is generated from alternative splicing during transcription, is expressed in human uterine cancers to a greater extent than other isoforms. Blocking activities of the PRL/PRLR_S1a axis with the antagonist G129R significantly reduced growth and progression of both orthotopic PTENwt and PTENmut uterine tumors. Data from reverse-phase protein arrays (RPPA) by in the resulting tumors showed that pathways involved in epithelial-mesenchymal transition such as PI3K/mTOR activities were significantly downregulated by G129R treatment. In addition, based on the RPPA data from the in vitro uterine cancer cells treated with G129R as monotherapy or in combination with PRL, we discovered a novel function of G129R in initiating cell death mediated by nuclear FOXO3a and inducing the G0/G1 arrest in both PTENwt and PTENmut uterine cancer cells. Furthermore, G129R decreased the nascent protein synthesis in these uterine cancer cells mediated by transcriptional suppressor EIF-4EBP1. Collectively, our findings reveal a new role of the PRLR_S1a isoform in uterine cancer and identify G129R as a potential therapeutic in uterine cancer. Citation Format: Yun-Fei Wen, Ying Wang, Shaolin Ma, Anca Chelari Raicu, Keith A. Baggerly, Anil K. Sood. Blockade of the short-form of prolactin receptor induces FOXO3a/EIF-4EBP1-mediated cell death in uterine cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3720.
See One, Do One, Teach One?
Authors: Martin I. Resnick
Journal: JAMA (1992)

<h3>To the Editor.</h3> —I read with interest Dr Stitham's<sup>1</sup>article on educational practices of medical students and residents and cannot agree with his conclusions. He paints a picture of a laissez faire attitude in which faculty members appear uninterested and aloof and are more concerned with research activities and patient care. Though these latter practices are certainly of importance, I disagree with his opinion that they supersede medical education. Much effort goes into the evaluation of students from their first day of medical school to their day of graduation. At our institution, a faculty committee in close association with the dean's office reviews all students on a regular basis and works closely with those students not making the grade. Tutorialsessions, professional counseling, and one-on-one interchange with faculty role models are encouraged and are routinely carried out in an attempt to sort out difficulties and correct them. Failing or marginal