tbuckley/cabot-search huggingface dataset:
P98 The effects of Th17 cytokines on liver parenchymal cells shape the microenvironment for local generation of Th17/Tc17 in inflammatory liver disease
Authors: E. H. Humphreys, G. M. Muirhead, R. H. Bhogal, B. Eksteen, S. C. Afford, Y. H. Oo, D. H. Adams
Journal: Gut (2011)

<h3>Introduction</h3> IL-17 secreting T cells (Th17<sub>h17</sub> and Tc17<sub>c17</sub>) are subsets of T lymphocytes that have been implicated in autoimmunity, inflammatory disease and provide a link between the innate and adaptive immune responses. High numbers of IL-17-producing T cells are found in close proximity to bile ducts in several liver diseases including primary biliary cirrhosis. IL-17 related cytokines have multiple effects on parenchymal cells in different tissues and may be involved in both effector responses and repair and regeneration. We recently reported increased numbers of liver infiltrating IL-17 secreting CD4 and CD8 T cells in chronic inflammatory liver disease. These cells also secrete IL-21 and IL-22 cytokines reported to promote epithelial repair. In the present study we report the pattern of IL-17, IL-21 and IL-22 receptor expression on hepatic parenchymal cells and demonstrate cell-specific effects of T<sub>h17</sub> cytokines on these target cells. <h3>Aim</h3> To assess the functional impact of Th17/Tc17 associated cytokines on hepatic parenchymal cells. <h3>Method</h3> Primary human cholangiocytes, hepatocytes and sinusoidal endothelial cells were assessed for IL-17, IL-21 and IL-22 receptor expression. The effects of stimulation with recombinant IL-17, IL-21, IL-22, TNF-a or IFN-g alone or in combination were compared on apoptosis, proliferation and cytokine secretion using flow cytometry with annexin or 7-AAD staining and in situ Ki67 staining and measurement of IL-1b, IL-6, IL-23 and TGF-b1 secretion by ELISA. <h3>Results</h3> All the parenchymal cell types expressed IL-21R and IL-22R. Th17 and Tc17 cytokines did not cause apoptosis but alone and in combination led to parenchymal cell proliferation. Cholangiocytes and hepatocytes responded best to IL-17, whereas sinusoidal endothelial cells were responsive to IL-22. Cholangiocytes responded to Th17/Tc17 cytokines by secreting high levels of IL-1b, IL-6, IL-23 and TGF-b1 all cytokines that support the survival of Th17 and Tc17 cells. <h3>Conclusion</h3> Liver parenchymal cells express IL-17, IL-21 and IL-22 receptors and proliferate in response to Th17/Tc17 cytokines. Cholangiocytes also respond to such cytokines by secreting Th17 polarising cytokines. Thus IL-17 related cytokines secreted by infiltrating lymphocytes may activate the epitheliome to generate a local environment characterised by cholangiocyte proliferation and Th17 cell survival. This response may contribute to the bile duct proliferation and persistent chronic inflammation that characterised many liver diseases.
A novel adenovirus-based system for facilitating retroviral hepatic gene transfer in vivo
Authors: M OTT
Journal: Hepatology (1996)

The multi-domain protein XRCC1 is without catalytic activity, but can interact with a number of known repair proteins. The interaction between the N-terminal domain (NTD) of XRCC1 and DNA polymerase β (pol β) is critical for recruitment of pol β to sites of DNA damage and repair. Crystallographic and NMR approaches have identified oxidized and reduced forms of the XRCC1 NTD, and the corresponding forms of XRCC1 have been identified in cultured mouse fibroblast cells. Both forms of NTD interact with pol β, but the interaction is much stronger with the oxidized form. The potential for formation of the C12-C20 oxidized conformation can be removed by alanine substitution at C12 (C12A) leading to stabilized reduced XRCC1 with a lower pol β binding affinity. Here, we compare cells expressing C12A XRCC1 (XRE8) with those expressing wild-type XRCC1 (XC5). Reduced C12A XRCC1 is detected at sites of micro-irradiation DNA damage, but provides slower recruitment of pol β. Expression of reduced XRCC1 does not affect sensitivity to MMS or H2O2. In contrast, further oxidative stress imposed by glutathione depletion results in increased sensitization of reduced XRCC1-expressing cells to H2O2 compared with wild-type XRCC1-expressing cells. There is no indication of enhanced H2O2-generated free radicals or DNA strand breaks in XRE8 cells. However, elevated cellular PAR is found following H2O2 exposure, suggesting BER deficiency of H2O2-induced damage in the C12A expressing cells.
Validation of encephalapp stroop for minimal hepatic encephalopathy diagnosis in elderly patients with cirrhosis: a multi-center study
Authors: Jasmohan S Bajaj, Jesse Xie, Andres Duarte-Rojo, Chathur Acharya, Megan Kelly, James Wade, Andrew Fagan, Edith Gavis, Mauricio Garcia, Vy Nguyen, Melanie White, Leroy Thacker, Christopher Flud, Hugo E. Vargas
Journal: Journal of Hepatology (2020)
War Neuroses
Authors: J. S. Bury
Journal: BMJ (1943)

This is a personal view about the recent high court decision around cardiopulmonary resuscitation (CPR). This opinion identifies that the judge failed to recognise the statutory role given to clinicians in identifying when a treatment is life sustaining. In failing to recognise the role of the clinician, the ruling in Winspear risks the likelihood of inappropriate CPR attempts.
Questions in Laboratory Methods
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Annual Review: Selected Topics in Ophthalmic Biochemistry
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Slippery Percentage.
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Carcinoid Heart Disease: Impact of Pulmonary Valve Replacement in Right Ventricular Function and Remodeling
Authors: Heidi M. Connolly, Hartzell V. Schaff, Charles J. Mullany, Martin D. Abel, Patricia A. Pellikka
Journal: Circulation (2002)

Background Carcinoid heart disease characteristically affects tricuspid (TV) and pulmonary valves (PV), and TV replacement is helpful in selected patients. There is uncertainty, however, regarding optimal surgical management of PV regurgitation. Methods and Results We reviewed 22 patients having operation for carcinoid heart disease and compared those having TV and PV replacement (n=12), to those who underwent TV replacement and excision of the PV (n=10). Pre- and postoperative right ventricular (RV) size and dysfunction were assessed by consensus of 2 echocardiographers blinded to type of surgical treatment. RV dysfunction was graded as none (0), mild (1), moderate (2), or severe (3). RV size was graded as normal (0), or mild (1), moderate (2), or severe (3) enlargement. Preoperatively, RV size (2.2±0.8 [no PVR]versus 2.7±0.6 [with PVR], P =0.15), RV dysfunction (0.9±0.9 [no PVR]versus 1.4±0.7 [with PVR], P =0.14), and NYHA class were similar in the 2 groups. Postop RV size decreased inpatients with PVR, 2.7±0.6 to 1.7±1.0 ( P =0.008), but did not change appreciably in those without PVR, 2.2±0.8 to 2.3±0.8 ( P =0.67). There was no significant change in RV dysfunction after surgery, 1.4±0.7 to 1.8±0.9 with PVR ( P =0.26) and 0.9±0.9 to 1.6±0.9 without PVR ( P =0.07). Conclusions PV replacement appears to have a beneficial effect on RV size in patients after surgery for carcinoid heart disease. This may have important implications for RV remodeling after PV replacement.
OVARIOTOMY.
Authors: R. S. Sutton.
Journal: JAMA (1884)

our local medical society in which the author an¬ nounced that the disease was the result of filth and heat.When he had concluded, a member asked, if that were true, how was it possible that any of the children in a certain locality escaped, inasmuch as said neighborhood was remarkable for its filth, and yet during the summer just passed, cholera infantum, in fact all forms of disease had failed to occur, and the whole region was as remarkable for its health.Speaking of medical societies brings up the fact that cur County Medica!Society now numbers its members up to about 500.This is the union of all
Judicial Executions
Authors: J. Barr
Journal: BMJ (1891)

<h3>Abstract</h3> A number of studies reported that influenza vaccination is associated with lower risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and/or coronavirus disease 2019 (COVID-19) morbidity and mortality. We conducted a matched, test-negative, case-control study to estimate effectiveness of influenza vaccination, using Abbott’s quadrivalent Influvac Tetra vaccine, against SARS-CoV-2 infection and against severe COVID-19. The study was implemented on a population of 30,774 healthcare workers (HCWs) in Qatar during the 2020 annual influenza vaccination campaign, between September 17, 2020 and December 31, 2020, before introduction of COVID-19 vaccination. The median age in the matched samples was 36 years (interquartile range (IQR), 32-44) for cases and 35 years (IQR, 32-42) for controls. The median duration between influenza vaccination and the PCR test was 43 days (IQR, 29-62). The estimated effectiveness of influenza vaccination against SARS-CoV-2 infection &gt;14 days after receiving the vaccine was 29.7% (95% CI: 5.5-47.7%). The estimated effectiveness of influenza vaccination against any severe, critical, or fatal COVID-19 was 88.9% (95% CI: 4.1-98.7%). Sensitivity analyses confirmed main analysis results. Recent influenza vaccination is associated with an appreciable reduction in the risk of SARS-CoV-2 infection and COVID-19 severity.
Plastic and Reconstructive Surgery, Baltimore
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Solid Foods May Increase Allergy Potential in Infants
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Impaired function of pancreatic islets from rats with portal hypertension resulting from cirrhosis and partial portal vein ligation
Authors: R Gomis
Journal: Hepatology (1994)

Increased circulating insulin and glucagon levels are a common observation in patients with cirrhosis, as well as in portal hypertensive models. Hyperinsulinemia and hyperglucagonemia may be caused either by increased beta- and alpha-cell secretion or by defective hepatic clearance of these hormones. To elucidate whether an abnormal endocrine pancreatic function might contribute to the hyperinsulinism or to the hyperglucagonism observed in chronic portal hypertension, insulin and glucagon secretion were measured in vitro in isolated pancreatic islets from rats with partial portal vein ligated and rats with cirrhosis caused by carbon tetrachloride poisoning. Both rats with partial portal vein ligation and rats with cirrhosis caused by carbon tetrachloride poisoning exhibited hyperinsulinism and hyperglucagonism as compared with control rats. Isolated pancreatic islets from both experimental portal hypertensive models showed an impaired insulin secretion after glucose stimulation. On the contrary, glucagon secretion was significantly increased, and there was a markedly enhanced response to arginine. This increased in vitro glucagon production could not be corrected, even in the presence of high glucose concentrations in the incubation medium. Therefore our data show that although hyperglucagonism in rats with partial portal vein ligation and in rats with cirrhosis caused by carbon tetrachloride poisoning is promoted by an enhanced alpha-cell secretion, hyperinsulinism is associated with impaired beta-cell secretion. (HEPATOLOGY 1994;19:1257–1261.)
Very, very imprecise
Authors: C. G. Roland
Journal: JAMA (1968)

Science depends on precise measurement, and the reporting of scientific observations demands precise language. Authors often use the word "very" as if it contributed to precision. It does not. "Very" derives ultimately from the Latin<i>verus</i>, meaning "true," and today's meanings all relate to this ancestor. One direct descendant is the adjectival use of "very" to mean real, true, or genuine, a usage now archaic or limited to poetry (for example, "has shown himself a very knave"). Another meaning emphasizes identity, coincidence, or significance ("this is the very place," "drank his wine to the very dregs"). In reporting scientific observations, writers use "very" in one of three ways: First, they combine this qualifier with words of quantity (time, distance, weight, and so on); second, they use "very" to intensify the meaning of a wide variety of nonquantitative words; and finally, they use "very" (incorrectly) with words which cannot be qualified.
La cura specifica delle brucellosi
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Correction to the Research Article Titled: “Dosage Thresholds for AAV2 and AAV8 Photoreceptor Gene Therapy in Monkey” by L. H. Vandenberghe, P. Bell, A. M. Maguire, C. N. Cearley, R. Xiao, R. Calcedo, L. Wang, M. J. Castle, A. C. Maguire, R. Grant, J. H. Wolfe, J. M. Wilson, J. Bennett
Journal: Science Translational Medicine (2011)
Transient occlusion of the middle cerebral artery
Authors: S. A. Hollin
Journal: JAMA (1965)

Four patients with arteriographically demonstrated occlusion of the main trunk of the middle cerebral artery were found, by subsequent arteriograms or postmortem examination, to have middle cerebral artery patency. Similar cases have been reported in the literature. The frequency of vessel patency after apparent occlusion is undetermined; its pathogenesis is not well understood. The finding of a patent vessel after previous angiographically demonstrated occlusion cannot be used as definite evidence of a beneficial effect from thrombolytic or other therapies.
Posey Palsy
Authors: Mark B. Skeen, Marvin P. Rozear, Joel C. Morgenlander
Journal: Annals of Internal Medicine (1992)

Letters1 November 1992Posey PalsyMark B. Skeen, MD, Marvin P. Rozear, MD, Joel C. Morgenlander, MDMark B. Skeen, MDSearch for more papers by this author, Marvin P. Rozear, MDSearch for more papers by this author, Joel C. Morgenlander, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-117-9-795_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: There has been growing public and legislative attention to potential hazards and appropriate use of physical restraint in patient care. We report a case of bilateral brachial plexus injury and unilateral axillary vein thrombosis due to the combined use of vest and wrist restraints.A 48-year-old male unrestrained driver suffered closed head injury in a head-on collision 17 months before his referral for bilateral hand weakness. On hospitalization after the accident, he was graded as Glasgow Coma Scale 14, with no evidence of acute cerebral injury by computed tomographic (CT) scan. His blood alcohol level was 200...References1. ScottGross TJ. Brachial plexus injury due to vest restraints [Letter]. N Engl J Med. 1989;320:598. CrossrefMedlineGoogle Scholar2. VogelBromberg CM. Proximal upper extremity compressive neuropathy associated with prolonged use of a jacket restraint [Abstract]. Muscle Nerve. 1990;13:860. Google Scholar3. DubeMitchell AE. Accidental strangulation from vest restraints. JAMA. 1986;256:2725-6. CrossrefMedlineGoogle Scholar4. Katz L. Accidental strangulation from vest restraints. JAMA. 1987; 257:2032-3. CrossrefMedlineGoogle Scholar5. TinettiLiuGinter MWS. Mechanical restraint and fall-related injuries among residents of skilled nursing facilities. Ann Intern Med. 1992;116:369-74. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Mark B. Skeen, MD; Marvin P. Rozear, MD; Joel C. Morgenlander, MDAffiliations: Duke University Medical Center Durham, NC 27710 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRestraints and immobilityRestraints and ImmobilityBrachial Plexus LesionsMinimizing the use of restrictive devices in dementia patients at risk for fallingVest restraint palsyPAGET SCHROETTER SYNDROME 1 November 1992Volume 117, Issue 9Page: 795-795KeywordsAlcoholsBloodComputed axial tomographyGlasgow coma scaleHead injuryHospitalizationsParalysisPatientsVeins ePublished: 1 December 2008 Issue Published: 1 November 1992 PDF downloadLoading ...