tbuckley/cabot-search huggingface dataset:
The Kidney and Oral Calcium Therapy
Authors: E. J. H.
Journal: Annals of Internal Medicine (1967)

Editorial Notes1 May 1967The Kidney and Oral Calcium TherapyE. J. H.E. J. H.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-5-1021 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCalcium carbonate for the treatment of peptic ulcer has tended to give way, in recent years, to aluminum-magnesium antacids in part because they are less constipating and more palatable. However, calcium carbonate does continue in use as an antacid. Indeed, support for its continued use has come from a recent study by Fordtran and Collyns (1). They showed, using a test more closely resembling normal conditions than the usual assay, that calcium carbonate is superior to an aluminum-magnesium hydroxide preparation in postcibal reduction of gastric acidity and peptic activity. Calcium carbonate is not a drug without hazards, nevertheless, and severe...References1. FORDTRANCOLLYNS JSJA: Antacid pharmacology in duodenal ulcer. New Eng. J. Med. 274: 921, 1966. CrossrefMedlineGoogle Scholar2. KIRSNER JB: Facts and fallacies of current medical therapy for uncomplicated duodenal ulcer. JAMA 187: 423, 1964. CrossrefMedlineGoogle Scholar3. MENGUY R: Peptic ulcer, in Current Therapy 1967. W. B. Saunders Co., Philadelphia, 1967, p. 299. Google Scholar4. SIEGEL CI: Therapy of duodenal ulcer. Johns Hopkins Med. J. 120: 89, 1967. MedlineGoogle Scholar5. MCMILLANFREEMAN DERB: The milk alkali syndrome: a study of the acute disorder with comments on the development of the chronic condition. Medicine (Balt.) 44: 485, 1965. CrossrefMedlineGoogle Scholar6. SCHWARTZRELMAN WBAS: Effects of electrolyte disorders on renal structure and function. New Eng. J. Med. 276: 452, 1967. CrossrefMedlineGoogle Scholar7. VINCENTRADCLIFF PCFJ: The effect of large doses of calcium carbonate on serum and urinary calcium. Amer. J. Dig. Dis. 11: 286, 1966. CrossrefMedlineGoogle Scholar8. BINSWANGER U: Nierenfunktion unter peroraler Calciumtherapie. Schweiz. Med. Wschr. 97: 140, 1967. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHypophosphataemic rickets and nephrocalcinosis in ostrich chicks brooded and reared on limestone sandRenal pathology of the fowl — A reviewAntacids and Anticholinergic DrugsARMAND LITTMAN, M.D., F.A.C.P., BRIAN H. PINE, M.D. 1 May 1967Volume 66, Issue 5Page: 1021-1022 ePublished: 1 December 2008 Issue Published: 1 May 1967 PDF downloadLoading ...
Abstract 2876: Early Retention and Subsequent Engraftment of Transplanted Progenitor Cells is Improved by Delivery within Collagen Matrix
Authors: Yan Zhang, Marc Lamoureux, Stephanie Thorn, Vincent Chan, Joel Price, Robert B Beanlands, Jean N DaSilva, Robert A deKemp, Erik J Suuronen, Marc Ruel
Journal: Circulation (2008)

Background: To investigate the mechanisms involved in the potentiation of cell therapy by delivery matrices, we evaluated the retention and engraftment of transplanted human circulating progenitor cells (CPCs) injected in a collagen matrix by using in vivo positron emission tomography (PET) imaging, ex vivo biodistribution, and immunohistochemistry. Methods: CPCs were labeled with 18 F-FDG and injected with or without a collagen type I-based matrix in the ischemic hindlimb muscle (IM) of rats (2x10 6 cells; n=15/group). Localization of cells was acquired by PET imaging (15 min) at 150 min post-injection. In addition, radionuclide biodistribution, immunofluorescence, and immunohistochemical examination of transplanted CPCs were performed at up to 14 days. Results: Cell labeling efficiency was CPC-concentration dependent (r=0.61, p &lt;0.001), but not 18 F-FDG-dose dependent. Labeled CPCs exhibited excellent short-term stability and viability. Persistence of 18 F-FDG radioactivity in cells was markedly greater than non-specific retention in the matrix. Wholebody (WB) PET images revealed better CPC retention in the IM and less non-specific leakage to other tissues when CPCs were delivered within the matrix (IM/WB retention ratio of 43.9±8.2%), compared to cells injected alone (22.3±10.4%; p =0.040) and to 18 F-FDG injected with or without the matrix (9.7±5.5% and 11.0±5.5%, respectively; p &lt;0.005). Radioactivity biodistribution confirmed that accumulation was increased (by 92.5%; p =0.024) in the IM and reduced (by 1.1 to 23.8%; p &lt;0.05) in non-specific tissues when cells were injected within the matrix, compared to cells injected alone. Anti-human mitochondria staining showed increased cell retention in the IM with use of matrices (3.0±2.1%) versus cells only (1.9±0.8%; p =0.048). At 14 days the number of CD31 + transplanted human cells was greater (1.6±0.1%) when injected within the matrix than injected alone (0.7±0.1%; p =0.004). Conclusions: Collagen-based delivery matrices improve the early retention of transplanted CPCs, which in turn favors subsequent cell engraftment in the ischemic tissue. This mechanism conferred by the matrix has potential implications for the optimization of cell therapy at the early stages after cell delivery.
Treatment of Torulopsis glabrata peritonitis with intraperitoneal amphotericin B
Authors: P. S. Rahko
Journal: JAMA (1983)

<i>Torulopsis glabrata</i>peritonitis occurred in a patient after surgery for a ruptured abdominal viscus. The infection was successfully treated with intraperitoneal amphotericin B alone. Pharmacokinetic information regarding the distribution and clearance of amphotericin B administered by this route is presented, and the clinical manifestations and treatment modalities for<i>T glabrata</i>and<i>Candida</i>peritonitis are reviewed. (<i>JAMA</i>1983;249:1187-1188)
Domiciliary Physiotherapy
Authors: B. D. M. Williams
Journal: BMJ (1966)

But whatever the attitude of our negotia- tors there can be no doubt that the proposal for "merit" awards to certain selected persons for doing no extra work and carrying no extra responsibility, but merely, as in much of the specialist field today, for orientating activities to catch the eye of those in authority more than for the benefit of the patient, will seriously split the profession once more.We shall have a hierarchy with its hangers-on in one camp and those without hope of getting on the band-wagon in the other.This is about the worst thing that could happen to general practice.Dr. John D. Avison (5 March, p. 608) says that "many strong voices may be silenced for ever " if awards of £2,500 a year are made a reward for silence.Dr. Avison was right in his prophecy, but it was fulfilled before he made it.The voices were already silenced and the village Hampdens up and down the country were already burnishing up their images so as to be in line for this apparent bonanza for which the rest of us in general practice will have to pay in one
Acute Changes in Renal Excretion of Water and Solute in Patients with Laennec's Cirrhosis Induced by the Administration of the Pressor Amine, Metaraminol.
Authors: D. L. Gornel
Journal: Annals of Internal Medicine (1961)

s1 May 1961Acute Changes in Renal Excretion of Water and Solute in Patients with Laennec's Cirrhosis Induced by the Administration of the Pressor Amine, Metaraminol.D. L. Gornel, M.D., L. M. Loewenstein, M.D., R. G. Lancestremere, M.D., S. Papper, M.D., F.A.C.P.D. L. Gornel, M.D., L. M. Loewenstein, M.D., R. G. Lancestremere, M.D., S. Papper, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-54-5-1063_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn 1958, one of the authors (S. P.) presented to the Annual Session of the College clinical and experimental observations in patients with Laennec's cirrhosis who were dying with azotemia. Those studies suggested the possibility that the mechanisms of renal failure in these instances is of circulatory origin, rather than a parenchymal lesion.Among a variety of attempts to alter renal circulation in this condition (characterized in part by decreased blood pressure) we studied the effects on renal excretion of the intravenous and intramuscular administration of the synthetic sympathomimetic amine, metaraminol. Since similar mechanisms might also be operative in patients... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1961Volume 54, Issue 5Page: 1063-1064KeywordsBlood pressureCirrhosisExcretionLesionsRenal circulationRenal failure Issue Published: 1 May 1961 PDF downloadLoading ...
Effect of Preventive Supplementation on Young Children in Niger—Reply
Authors: Sheila Isanaka
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medical League.
Authors: Douglas H. Stewart
Journal: JAMA (1897)

New York, May 11, 1897. <h3>To the Editor:</h3> —In answer to many inquiries about the New York Medical League, and hoping to set at rest many vague editorial surmises as to its purposes, I send you the following preamble from its constitution. The objects of the League shall be: To unite fraternally Doctors of Medicine, in good standing, for mutual protection and benefit, by advancing the interests of its members professionally, financially and politically. By united action to secure the enactment of such laws as shall benefit the medical profession. To influence Doctors of Medicine to be good citizens, in the highest sense of the term, and to urge upon them the necessity of taking active part in matters pertaining to State and local government and of voting at every election. To collect evidence of hospital and dispensary abuses and to exclude well-to-do persons from medical charities, thereby securing proper
“Stop smoking!” Do we say it enough?
Authors: Jessica Ann Reifer Hildebrand, Sangeeta Sastry, Ashley Adams
Journal: Journal of Clinical Oncology (2012)

268 Background: There are clear benefits of smoking cessation after the diagnosis of Bronchogenic Carcinoma (BC). Patients who quit smoking report lower levels of pain and are less likely to develop a second primary tumor when compared to patients who continue to smoke after they are diagnosed with BC. Persistent smoking is also associated with poor performance status and survival outcomes. Evidence suggests that smokers are more likely to quit if they are counseled by their physicians yet, there may be a prevailing belief among physicians that treating tobacco dependence is futile in this population. The purpose of this study was to investigate whether physicians addressed smoking cessation with patients who were diagnosed with BC. Methods: A retrospective chart review of patients who were diagnosed with BC was conducted at a community medical center between 2008 and 2010, using the hospital’s cancer registry. Demographic information including age, race, sex, AJCC stage, and smoking status at the time of diagnosis was collected. Evidence of tobacco cessation counseling was sought through billing codes, physician notes, and orders surrounding the time of diagnosis. Results: A total of 948 patients were diagnosed with lung cancer between 2008 and 2010. 438 were current smokers at diagnosis, 422 were former smokers, and 88 had never smoked. Of the 438 smokers, only 36% were counseled on smoking cessation. On average, each patient encountered 3 different physicians in both the inpatient and outpatient settings. Of note, stage I patients were 1.7 times more likely to be counseled than those with stage IV disease (p=0.017). There was no significant difference between the counseled group and the non-counseled group in regards to age, race, or sex. Conclusions: In spite of evidence that smoking cessation is beneficial even after the diagnosis of BC, physicians are not counseling their patients sufficiently. Reasons physicians may fail to counsel include an inability to effectively assess tobacco dependence, competing concerns during patient encounters, and reduced awareness of current quality measures. With the implementation of quality improvement programs, it will be interesting to see if smoking cessation counseling for patients with BC improves in the community setting.
Abstract A2-45: R2: Accessible web-based genomics analysis and visualization platform for biomedical researchers
Authors: Jan Koster, Jan J. Molenaar, Rogier Versteeg
Journal: Cancer Research (2015)

Abstract In this era of explosive high throughput (HT) genomics data generation, there is a growing need for accessible software solutions that can help unlock biological/clinical characteristics from such data. With the biomedical researcher (with limited or no bioinformatics skills) in mind, we developed a comprehensive web-based system called R2 (http://r2.amc.nl). R2 aids in the analysis and visualization of private/shielded as well as public high throughput data and their associated annotated features. The R2 platform consists of a database storing both publicly accessible as well as shielded datasets with unified gene annotation, supplemented with a large suite of tools that can be used on these data, and their associated annotation. As such the user experiences the same look &amp; feel throughout the mining process. In the public section, R2 hosts over 60,000 HT samples. Next to gene expression (microarray and RNA-seq), the platform is also being employed in the integration, analysis and visualization of other data types, such as aCGH, SNP, ChIP, methylation, miRNA, and NGS whole genome sequencing information. R2 contains an expanding set of interactive analyses which are heavily inter-connected, allowing users to quickly hop from one view (representation of the data) to another. Analyses include, correlation, differential expression, gene sets, gene ontology, transcription factor binding sites, PCA, kmeans, Kaplan Meier scans, signature creation etc. Visualizations include, various gene oriented plots, heatmaps, circos, embedded genome browser, Venn, etc. Many parts of the R2 platform are publicly accessible through the http://r2.amc.nl portal. The R2 gene expression analysis tools have thus far been used in more than 180 peer-reviewed scientific publications including journals as Nature, Nature Genetics and Cell. R2 also supports restricted / shielded use and is used in many (inter)national collaborative efforts involving unpublished datasets. The webservers have been serving over 900.000 pages over the past 12 months (Nov 2014). Citation Format: Jan Koster, Jan J. Molenaar, Rogier Versteeg. R2: Accessible web-based genomics analysis and visualization platform for biomedical researchers. [abstract]. In: Proceedings of the AACR Special Conference on Translation of the Cancer Genome; Feb 7-9, 2015; San Francisco, CA. Philadelphia (PA): AACR; Cancer Res 2015;75(22 Suppl 1):Abstract nr A2-45.
THE ADMINISTRATION OF CALCIUM SALTS
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Polio Vaccination
Authors: J. F. Schneider
Journal: JAMA (1962)

<h3>To the Editor:—</h3> In an article by Hilary Kropowski of Philadelphia (<i>JAMA</i><b>178</b>:1151 [Dec. 23] 1961), the opening sentence: "... research in vaccination with live attenuated polioviruses goes back 11 years," bothered me no end. As a graduate of Temple University Medical School in 1939, I am quite familiar with the work of Dr. John Kolmer and his vaccinations against polio in Philadelphia about 1934 and 1935. It is interesting to note that followups in recent years have shown that those who had been vaccinated by Dr. Kolmer and were checked still evidenced the good effect of his vaccine. The Wistar Institute is close enough to Dr. Kolmer's Institute for Cutaneous Medicine that I'm sure Hilary could verify this for himself.
Sex "deviation"
Authors: M. S. Calderone
Journal: JAMA (1971)

<h3>To the Editor.—</h3> In expressing appreciation of the enlightened and enlightening paper of Marmor (<b>217</b>:165, 1971), I would like to add a comment to the first paragraph of his comment, in which he states The fact that we now refer to sexual "deviations" rather than to "perversions" already represents an evolutionary change within our culture toward a moral objective and scientific approach to these problems, in contrast to the highly moralistic and perjorative approach of the previous generation. Perhaps some day we shall talk simply of "variations" in sexual object choice. I would like to urge that, in the interests of true scientific objectivity, we replace the term "deviant behavior" as soon as possible with the term "variant behavior." In public lectures, in which for several years I have been trying to reach the public in nontechnical terminology with the objective understandings so well stated by Marmor, I have
Binocular Ophthalmoscopy
Authors: J. Z. Laurence
Journal: BMJ (1862)

Substituting the numerical values of P'd, p'c, and b d, we find that Prc=24 inches= the distance we shall have (original VA5.0ntunTrationS, to retreat from P' for its binocular perception-too great a distance for all practical purposes, more especially ORIGINAL COM31UNICATIONS.
Mechanisms of General Anesthesia
Authors: N. P. Franks, W. R. Lieb
Journal: Environmental Health Perspectives (1990)

Although general anesthetics are often said to be nonspecific agents, it is likely that they act at a much more restricted set of target sites than commonly believed. The traditional view has been that the primary targets are lipid portions of nerve membranes, but recent evidence shows that the effects on lipid bilayers of clinically relevant levels of anesthetics are very small. Effects on most proteins are also small, but there are notable examples of proteins that are extremely sensitive to anesthetics and mimic the pharmacological profile of anesthetic target sites in animals. Such target sites are amphiphilic in nature, having both hydrophobic and polar components. The polar components appear to behave as good hydrogen-bond acceptors but poor hydrogen-bond donors. Although the targets can accept molecules with a wide variety of shapes and chemical groupings, they are unaffected by molecules exceeding a certain size. Overall, the data can be explained by supposing that the primary target sites underlying general anesthesia are amphiphilic pockets of circumscribed dimensions on particularly sensitive proteins in the central nervous system.
THE CAUSES OF UNFAVORABLE SYMPTOMS FOLLOWING GASTROENTEROSTOMY
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Changing attitudes toward therapeutic abortion
Authors: K. R. Niswander
Journal: JAMA (1966)

Few topics are as controversial as that of therapeutic abortion. Not long ago the news media reported fully the predicament of the pregnant women who had taken thalidomide. The necessity for one woman to go to Sweden to obtain an abortion previously denied her in this country dramatized the plight of these women and ignited further discussion. Many people were ready to reconsider the probability that there are conditions which justify the termination of a pregnancy, in which case, the means to such termination should be made legally available. The question remains so controversial, however, that even when the policy of a particular hospital is well established, some staff members diligently work to tighten the requirements for abortion, whereas others strive to liberalize hospital policy. Evidence is accumulating, nevertheless, that our attitudes toward abortion are changing. Ashley Montagu<sup>1</sup>has pointed out the manner in which our society may abandon