tbuckley/cabot-search huggingface dataset:
No-Tobacco Day targets workplace as UN World Health campaign moves into fifth year
Authors: P. Gunby
Journal: JAMA (1992)

SUNDAY is the fifth World No-Tobacco Day. The sponsoring World Health Organization says this year's theme is "Tobacco-free Workplaces." The World Health Organization is an autonomous unit within the United Nations system with headquarters in Geneva, Switzerland. Hiroshi Nakajima, MD, PhD, the organization's director-general who is committed to major international reductions in tobacco use, has made recent appearances in the United States including at the John Hopkins University School of Hygiene and Public Health's 75th anniversary program in Baltimore, Md, late last month. He says that the World Health Organization already is appealing to public officials and "to the civic sense of individuals" to halt the use of tobacco. Now, he says, "on May 31, we're turning to workers and employers." So, apparently, is at least one tobacco company. It's reported that Philip Morris Inc is sponsoring 15 country music concerts this year, 10 of which are to be on
Child mistreatment remains an ugly problem
Authors: D. E. Riesenberg
Journal: JAMA (1986)

There may be cause for cautious optimism in connection with the ugly problem of child abuse and neglect. But much clearly remains to be done. Nearly a quarter century ago, the late Henry Kempe, MD, and coauthors awakened the national conscience by coining the phrase "the battered-child syndrome" (<i>JAMA</i>1962;181:17-24 and<i>JAMA</i>[MEDICAL NEWS] 1984;251:2069). Leaders in the fight against child abuse gathered in Chicago recently at the Seventh National Conference on Child Abuse and Neglect to review how far remedial efforts have come—and how much farther they have to go—in the aftermath of Kempe's landmark paper. Some of the conclusions depend on how the data are interpreted. Richard J. Gelles, PhD, professor of sociology and anthropology and dean of the College of Arts and Sciences at the University of Rhode Island, Kingston, and Murray A. Straus, PhD, professor of sociology and director of the Family Violence Research Program, University
Reply to E. Hindié
Authors: Andrea Maurichi, Rosalba Miceli, Hanna Eriksson, Julia Newton-Bishop, Jérémie Nsengimana, May Chan, Andrew J. Hayes, Kara Heelan, David Adams, Roberto Patuzzo, Francesco Barretta, Gianfranco Gallino, Catherine Harwood, Daniele Bergamaschi, Dorothy Bennett, Konstantinos Lasithiotakis, Paola Ghiorzo, Bruna Dalmasso, Ausilia Manganoni, Francesca Consoli, Ilaria Mattavelli, Consuelo Barbieri, Andrea Leva, Umberto Cortinovis, Vittoria Espeli, Cristina Mangas, Pietro Quaglino, Simone Ribero, Paolo Broganelli, Giovanni Pellacani, Caterina Longo, Corrado Del Forno, Lorenzo Borgognoni, Serena Sestini, Nicola Pimpinelli, Sara Fortunato, Alessandra Chiarugi, Paolo Nardini, Elena Morittu, Antonio Florita, Mara Cossa, Barbara Valeri, Massimo Milione, Giancarlo Pruneri, Odysseas Zoras, Andrea Anichini, Roberta Mortarini, Mario Santinami
Journal: Journal of Clinical Oncology (2020)

We thank Hindi é1 for his interest in our study, 2 and we are happy to provide the clarifications requested.We agree that our nomogram has not been prospectively tested on unselected patients with thin melanoma.Although prospective testing is desirable, it would not be ethical to use unselected patients with stage T1 melanoma because sentinel node biopsy (SNB) would be overtreatment in most cases.
COURT-MARTIAL OF A NAVAL MEDICAL OFFICER.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A phase I clinical trial of PSMA-directed/TGFβ-insensitive CAR-T cells in metastatic castration-resistant prostate cancer.
Authors: Vivek Narayan, Whitney Gladney, Gabriela Plesa, Neha Vapiwala, Erica Carpenter, Shannon L. Maude, Priti Lal, Simon F. Lacey, Jan Joseph Melenhorst, Ronnie Sebro, Michael Farwell, Wei-Ting Hwang, Michael Moniak, Joan Gilmore, Lester Lledo, Karen Dengel, Amy Marshall, Christina Marie Coughlin, Carl H. June, Naomi B. Haas
Journal: Journal of Clinical Oncology (2019)

TPS347 Background: Adoptive immunotherapy with Chimeric Antigen Receptor (CAR)-T cells has transformative potential for the treatment of cancer. However, a primary challenge to the success of these therapies in prostate cancer is the immunosuppressive microenvironment, including high levels of Transforming Growth Factor-beta (TGFβ), encountered by re-directed T cells upon tumor infiltration. Importantly, these immunosuppressive functions of TGFβ can be abrogated in T cells using a dominant negative TGFβ receptor (TGFβRdn), thereby enhancing antitumor immunity. In in vivo disseminated prostate cancer models, co-expression of TGFβRdn on PSMA-redirected CAR-T cells led to increased T cell proliferation, enhanced cytokine secretion, resistance to exhaustion, long-term persistence, and greater tumor eradication. Methods: We initiated a first-in-human phase 1 clinical trial to evaluate the safety and preliminary efficacy of lentivirally-transduced PSMA-directed/TGFβ-insensitive CAR-T cells (CART-PSMA-TGFβRdn) in men with metastatic CRPC. In preliminary dose-escalation cohorts, patients received a single dose of 1-3 x 10 7 /m 2 (Cohort 1) or 1-3 x 10 8 /m 2 (Cohort 2) CART-PSMA-TGFβRdn cells without lymphodepleting chemotherapy in a 3+3 design. In Cohort 3, patients will receive the MTD of CART-PSMA-TGFβRdn following a lymphodepleting regimen of cyclophosphamide and fludarabine. All patients provide newly obtained metastatic tumor biopsies at baseline, as well as on day +10 following the CAR-T cell infusion and at disease progression. CAR-T expansion and persistence in peripheral blood and trafficking to target tissues is evaluated via quantitative PCR of CART-PSMA-TGFβRdn DNA. Bioactivity of CART-PSMA-TGFβRdn cells is evaluated via multiplex immunoassays. Additional correlative studies include enumeration and phenotyping of circulating tumor cells and DNA. Cohorts 1 and 2 have been completed without observed DLT. Interestingly, a reversible cytokine release syndrome has been observed that is responsive to tocilizumab. Enrollment in Cohort 3 began in September 2018. Cohort expansions will examine serial CART-PSMA-TGFβRdn re-treatment strategies. Clinical trial information: NCT03089203.
Psoriderm.
Authors: T. W. Stewart, F. F. Hellier
Journal: British Journal of Dermatology (1964)

Journal Article Psoriderm. Get access T. W. Stewart, T. W. Stewart Leeds Search for other works by this author on: Oxford Academic Google Scholar F. F. Hellier F. F. Hellier Leeds Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 76, Issue 11, 1 November 1964, Page 494, https://doi.org/10.1111/j.1365-2133.1964.tb15493.x Published: 01 November 1964
Radiation Research, New York
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A PROPOSED INTERNATIONAL COMMISSION ON INSANITY.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Method for the Quantitation of Lactic Dehydrogenase in Vertical Starch Gel
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MUSCULAR WORK AND PROTEIN METABOLISM
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Emergency Medicine
Authors: Lewis R. Goldfrank
Journal: JAMA (1995)

Recent published reports from the Institute of Medicine's Division of Health Care Services, Emergency Medical Services for Children, and the Josiah Macy Jr Foundation's Conference on the Role of Emergency Medicine in the Future of American Medical Care, as well as "A Public Health Approach to Emergency Medicine: Preparing for the Twenty-first Century,"<sup>1</sup>suggest new roles for emergency medicine in areas of public health. Emergency medicine plays a crucial role in the public's access to essential health care. This care can be used to help achieve primary preventive health strategies, such as childhood immunization, and secondary preventive care, such as intervening in the destructive behavior patterns of alcoholics and substance abusers. Nonfinancial barriers to health care access, such as patient race, diagnosis, geographic location, social class and culture, gender, and age, are more complex and possibly more insoluble problems than the lack of health insurance.<sup>2</sup>Such populations as
EFFECTS OF HYPOTENSION DUE TO HEMORRHAGE AND OF BLOOD TRANSFUSION ON RENAL FUNCTION IN DOGS
Authors: A. C. Corcoran, Irvine H. Page
Journal: The Journal of Experimental Medicine (1943)

On page 207, Vol. 78, No. 3, September 1, 1943, in footnote 3, section 1, line 1, the numeral 5 should be substituted for the numeral 8.
Abstract O.62: Estimation Of The Severity Of Coronary Artery Aneurysm By Z-score Of The Internal Diameter In Kawasaki Disease.
Authors: Naoya Fukushima, Masaru Miura, Toru Kobayashi, Shigeto Fuse, Tsutomu Saji, Hiroyuki Yamagishi, Taichi Kato, Kenji Hamaoka, Yuichi Nomura, Ryuji Fukazawa, Hitoshi Kato, Keiichi Hirono, Kenji Suda
Journal: Circulation (2015)

Background: The standard values of normal coronary artery internal diameters in Japanese children have been recently established, making it possible to calculate Z-scores based on body surface area. The aim of this study was to clarify the appropriate cut-off points of coronary artery aneurysm (CAA) Z-scores to predict coronary events such as stenosis, obstruction, and thrombosis in patients with Kawasaki disease (KD). Methods: In this multicenter retrospective study, we investigated height, weight, CAA diameters measured by echocardiography in acute phase KD, and coronary events in CAA patients with KD (age 18 years or younger) who had coronary angiography from 1992 to 2011. Results: Interim analysis was performed on data of the 928 patients recruited from 45 institutions. Body surface area (calculated from height and weight) and CAA diameters were available in 702, 680, and 539 cases of right coronary artery (RCA), left main trunk (LMT), left anterior descending artery (LAD), respectively. Coronary events occurred in 62 RCA cases (8.8%), 8 LMT cases (1.2%), and 45 LAD cases (8.3%) . Areas under the ROC curves to predict coronary events were similar for actual diameter, Z-score, and the ratio of actual diameter to that showing a Z-score of zero in each segment. The cut-off points for the actual diameter, Z-score, and ratio which yielding the highest sensitivity plus specificity were 6.3 mm, 9.6, and 3.9 times for RCA; 7.4 mm, 11.1, and 2.8 times for LMT; and 5.3 mm, 8.9, and 3.5 times for LAD. Conclusions: We identified cut-off Z-scores for CAA diameters useful for coronary events prediction. Attention should be paid to coronary events when the Z-score for CAA diameter is over 10.
Clinical Lectures on Certain Diseases of the Chest
Authors: A. T. H. Waters
Journal: BMJ (1867)

LECTURE III.-PNEUMONIA (continucd).GENTLEMEN,-I propose, in this and some following lectures, to speak to you of the treatment of pneumonia; and, in doing so, I shall refer you to cases which you have seen in the wards lately, and to others which have occurred in previous sessions, and of which notes have been taken.A careful record has been kept of all the cases of pneumonia which I have had under my treatment in this hospital.The symptoms and physical signs which have existed in each case have been observed at the bedside from day to day, and then and there recorded, together with the treatment which has been adopted.It is only by a plan of this kind that you can arrive at anything like scientific accuracy in reference to your cases, or that they can become valuable as standards of refer- ence, or as illustrations of any method of treatment.In hospital prac- tice alone is it possible to follow out such a system-to take down the details of a case of acute disease, so as to render it of real value in re- gard to any scientific inquiry.I may at once remark, that no single line of practice will, in my opinion, ever be found applicable to all cases of pneumonia.In the treatment of each case, you must have regard, not simply to the amount of lung involved, or the stage which the disease has reached, but also, and more especially, to the constitutional condition of the patient, the frequency and character of the pulse, and the antecedent circumstances, as far as you are able to ascertain them.Bear in mind that it is the patient himself, and not simply his diseased lung, which is the subject of your treatment.You will have observed that the treatment which I adopt is not cha-
No Diphtheria Epidemic at Eau Claire.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Impact of Climatic Change on the Northern Latitude Limit and Population Density of the Disease-Transmitting European Tick Ixodes ricinus
Authors: Elisabet Lindgren, Lars Talleklint, Thomas Polfeldt
Journal: Environmental Health Perspectives (2000)

We examined whether a reported northward expansion of the geographic distribution limit of the disease-transmitting tick Ixodes ricinus and an increased tick density between the early 1980s and mid-1990s in Sweden was related to climatic changes. The annual number of days with minimum temperatures above vital bioclimatic thresholds for the tick's life-cycle dynamics were related to tick density in both the early 1980s and the mid-1990s in 20 districts in central and northern Sweden. The winters were markedly milder in all of the study areas in the 1990s as compared to the 1980s. Our results indicate that the reported northern shift in the distribution limit of ticks is related to fewer days during the winter seasons with low minimum temperatures, i.e., below -12 degrees C. At high latitudes, low winter temperatures had the clearest impact on tick distribution. Further south, a combination of mild winters (fewer days with minimum temperatures below -7 degrees C) and extended spring and autumn seasons (more days with minimum temperatures from 5 to 8 degrees C) was related to increases in tick density. We conclude that the relatively mild climate of the 1990s in Sweden is probably one of the primary reasons for the observed increase of density and geographic range of I. ricinus ticks.
BRONCHO-PNEUMONIA FROM THE B. COLI COMMUNE.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal