tbuckley/cabot-search huggingface dataset:
WATER IN THE BLOOD
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Function of the Alpha Cell in Diabetic Ketoacidosis
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
S76 Proteolytic Cleavage of Elafin by 20S Proteasome May Contribute to Inflammation in Acute Lung Injury
Authors: A Kerrin, S Weldon, A Chang, T Craig, AJ Simpson, C O’Kane, DF McAuley, C Taggart
Journal: Thorax (2012)

<h3>The Aim</h3> of this study was to characterise temporal changes in elafin concentration in patients with acute lung injury (ALI) and to evaluate whether a decrease in elafin levels is due to elevated protease activity. Previous work has shown that unregulated protease activity can cause proteolytic cleavage of elafin, impairing the innate immune function of the protein. Bronchoalveolar lavage fluid (BALF) was obtained from patients with ALI within 48 hours of onset of ALI (day 0), at day 3 and at day 7. Elafin levels were quantified by ELISA Elafin susceptibility to proteolytic cleavage by ALI BALF was assessed by Western blot and by HPLC-Mass Spectrometry. Elafin levels were found to be significantly increased at the onset of ALI compared to healthy volunteers and fell significantly by day 7 compared to day 0. In contrast, levels of secretory leukocyte protease inhibitor (SLPI) did not decrease over time. This decrease in elafin was due to cleavage by the 20S proteasome which was significantly increased in ALI BALF. Incubation of ALI BALF with the proteasome inhibitor epoxomicin confirmed that 20S proteasome protease activity was responsible for proteolytic cleavage of elafin resulting in diminished anti-elastase activity. In addition, free neutrophil elastase (NE) activity significantly increased in ALI BALF from day 0 to day 7. In conclusion, elafin concentrations decrease within the pulmonary compartment over the course of ALI as a result of proteolytic degradation. This loss of elafin may predispose, in part, to excessive inflammation in ALI.
Ball-and-Socket Coronary Artery Cannulae
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pharmacology
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
* Evaluation of fibroblast growth factor 19 in the diagnosis of bile acid diarrhoea
Authors: S. Pattni, T. Dew, M. Srinivas, P. Basumani, K. D. Bardhan, J. R. F. Walters
Journal: Gut (2011)

<h3>Introduction</h3> The prevalence of bile acid diarrhoea (BAD) is estimated to be 1%, but the condition remains under diagnosed, partly because the selenium homocholic acid taurine (SeHCAT) test is not widely available. Fibroblast Growth Factor 19 (FGF19) produced in the terminal ileum in response to bile acid absorption plays an important role as a negative regulator of bile acid synthesis and low median FGF19 levels were shown in patients with primary BAD. The aim of this study was to evaluate the relationship between fasting FGF19 levels and SeHCAT in a large prospective group of patients defined by SeHCAT results. We also compared FGF19 levels at the time of colonoscopy in order to assess the effect of bowel preparation. <h3>Methods</h3> Patients recruited with chronic diarrhoea had SeHCAT testing as part of routine workup and provided fasting blood samples. Group 1 (n=74) were diagnosed as having BAD with a SeHCAT value of less than 15% and included patients with any of the possible causes of BAD. Group 2 patients (n=63) had SeHCAT values of greater than 15%. Serum FGF19 was measured in all patients by ELISA. Data were analysed to compare the relationship between FGF19 and SeHCAT in both groups. 17 patients had additional blood samples taken before colonoscopy after a standard bowel prep. <h3>Results</h3> FGF19 and SeHCAT were positively related (r=-0.49 Spearman rank correlation). The median FGF19 values in Group 1 and Group 2 were 146 pg/ml and 242 pg/ml respectively (p&lt;0.001, Mann-Whitney). The optimum sensitivity and specificity for FGF19 were at a level of 150 pg/ml (47% and 89% respectively) based on a SeHCAT cut off value of 15%. For a SeHCAT cut off value of 10% the optimum sensitivity and specificity for FGF19 were at a level of 146 pg/ml (58% and 85%). The area under the curve on a ROC analysis for predicting BAD was 0.72 (95% CI 0.63 to 0.80) for FGF19 compared to SeHCAT of &lt;15%, with a positive predictive value of 83% and a negative predictive value of 62%. The median FGF19 level in patients with chronic diarrhoea prior to colonoscopy compared to a random fasting FGF19 level was 103 pg/ml and 158 pg/ml respectively (p&lt; 0.044, Wilcoxon test). <h3>Conclusion</h3> The use of SeHCAT to diagnose BAD is currently the gold standard test of choice, but has its limitations. In this large prospective group we have shown a positive correlation between SeHCAT and FGF19. Potentially FGF19, which is a simple blood test, could be utilised as an alternative diagnostic or screening test for this condition. Further development and refinement to account for factors such as obesity, timing of a sample, and the effect of bowel preparation for colonoscopy may improve the sensitivity and specificity of the test.
Evidence on health effects of housing improvements is scarce
Journal: BMJ (2001)

Evidence on health effects of housing improvements is scarce Despite strong observational evidence linking housing and health, it is still not known if housing improvements can improve health.Thomson et al (p 187) conducted a systematic review of studies of housing interventions on health.Although many of the studies found that health improved after the interventions, the studies were small and often did not adjust for potential confounding factors.
Incorrect Wave 4 Reporting
Authors: Yoichiro Takayanagi, Adam Spira, Ramin Mojtabai
Journal: JAMA Psychiatry (2018)

Yoichiro Takayanagi, MD, PhD; Adam P. Spira, PhD; Kimberly B. Roth, MHS; Joseph J. Gallo, MD, MPH; William W. Eaton, PhD; Ramin Mojtabai, MD, PhD, MPH
CCM1/ICAP-1 complex controls β1 integrin-dependent endothelial contractility and fibronectin remodelling
Authors: Eva Faurobert, Claire Rome, Justyna Lisowska, Sandra Manet-Dupé, Gwénola Boulday, Marilyne Malbouyres, Martial Balland, Anne-Pascale Bouin, Michelle Kéramidas, Daniel Bouvard, Jean-Luc Coll, Florence Ruggiero, Elisabeth Tournier-Lasserve, Corinne Albiges-Rizo
Journal: The Journal of Experimental Medicine (2013)
Primary Care, Cancer
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Environment
Authors: Neal E. Baxter
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Guidelines for the appropriate use of do-not-resuscitate orders. Council on Ethical and Judicial Affairs, American Medical Association
Journal: JAMA (1991)

Cardiopulmonary resuscitation (CPR) is routinely performed on hospitalized patients who suffer cardiac or respiratory arrest. Consent to administer CPR is presumed since the patient is incapable at the moment of arrest of communicating his or her treatment preference, and failure to act immediately is certain to result in the patient's death. Two exceptions to the presumption favoring CPR have been recognized, however. First, a patient may express in advance his or her preference that CPR be withheld. If the patient is incapable of expressing a preference, the decision to forgo resuscitation may be made by the patient's family or other surrogate decision maker. Second, CPR may be withheld if, in the judgment of the treating physician, an attempt to resuscitate the patient would be futile. In December 1987, the American Medical Association's Council on Ethical and Judicial Affairs issued a series of guidelines to assist hospital medical staffs in formulating appropriate resuscitation policies. The Council's position on the appropriate use of CPR and do-not-resuscitate orders is updated in this report.
The Hypothalamus
Authors: Benjamin Boshes
Journal: JAMA (1971)

<i>The Hypothalamus</i>represents a new generation of knowledge which was acquired since the publication of the 1940 monograph by the same title. The latter, the Proceedings of the Association for Research in Nervous and Mental Diseases of 1939, was a remarkable volume dedicated to Stephen Walter Ranson. The current book pays respect to the past and wisely points up that much information comes from the errors which the test of time finally recognized as progress. The delightful opening chapter, by Evelyn Anderson, frankly portrays the controversial stands of the giants of the turn of the century who were charting this terra incognita. Even the immortal Harvey Cushing is taken gently to task as many of his dissenters proved later to be correct. This book suggests that the modern era began with the work of Ranson, and this reviewer was privileged to watch and even help in some of the early
Point Mutations Found in the Juxtamembrane Domain of FLT3 Define a New Class of Activating Mutations in AML.
Authors: Carola Reindl, Ksenia Bagrintseva, Susanne Schnittger, Joachim W. Ellwart, Katja Wenig, Karl-Peter Hopfner, Wolfgang Hiddemann, Karsten Spiekermann
Journal: Blood (2005)
Gram Stain
Authors: Joseph F. John Jr.
Journal: Annals of Internal Medicine (1998)

Letters15 December 1998Gram StainJoseph F. John Jr., MDJoseph F. John Jr., MDUniversity of Medicine and Dentistry of New Jersey; New Brunswick, NJ 08903Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-129-12-199812150-00042 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:It is hard to believe, but true. The title perplexed me: “The Gram Stain” [1]. Who would write about such an arcane topic these days? I read it. My chest tightened a bit. I had just come back from our clinical microbiology laboratory. I was worried about what I saw on that slide I just prepared, covered no longer by a milky fluid from a draining back but only with a hint of the pink safranin. Under the microscope, a ropy, fibrin mesh held dearly to tired neutrophils rimmed by long chunky pink rods. It was infected. ...References1. Fournier AM. The Gram stain. Ann Intern Med. 1998; 128:776. Google Scholar Author, Article, and Disclosure InformationAffiliations: University of Medicine and Dentistry of New Jersey; New Brunswick, NJ 08903 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 December 1998Volume 129, Issue 12Page: 1083KeywordsClinical microbiologyFibrinNeutrophilsResearch laboratoriesThorax Issue Published: 15 December 1998 CopyrightCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Immunologic aspects of neurological and neuromuscular diseases
Authors: B. Zweiman
Journal: JAMA (1987)

THE NERVOUS system has traditionally been considered to be an "immunologically privileged" site that is shielded by functional or anatomic barriers from systemic immune responses.<sup>1</sup>However, several lines of experimental and clinical evidence suggest that immune responses can affect and even take place within the nervous system. For example, most of the immunoglobulins (Igs) in the cerebrospinal fluid (CSF) are secreted within the neuraxis. This may involve more ready trafficking of immunocompetent cells into the nervous system than previously suspected. Some nervous system and lymphoid cells may express similar receptors for certain agonists and/or cross-reacting cell surface determinants. These events may be suggested by immunologic findings in the clinical disorders described later herein. <h3>IDIOPATHIC POLYNEURITIS (GUILLAIN-BARRÉ SYNDROME) Clinical Features</h3> Guillain-Barré syndrome (GBS) is characterized pathologically by cellular infiltration of the peripheral nervous system with lymphocytes and macrophages and by destruction of myelin.<sup>2</sup>It is characterized clinically by subacute
Abstract 2136: Correlating the expression of protein kinase C isozymes with the transformed phenotype in colorectal cancer
Authors: Catríona M. Dowling, James J. Phelan, Mary Clare Cathcart, Brian Mehigan, Paul McCormick, Tara Dalton, John C. Coffey, Jacintha O'Sullivan, Patrick A. Kiely
Journal: Cancer Research (2015)

Abstract Protein Kinase C (PKC) is a family of serine/threonine kinases that are involved in almost every signal transduction cascade in cells. PKC enzymes are activated by second messangers and respond to specific environmental cues. The development of PKC modulators with anti-cancer therapeutic potential is a major target in cancer. However, this task is made difficult because PKC has an important role to play in normal processes and the PKC family consists of at least 9 different isozymes. Our hypothesis is that PKC expression, activity and localisation are altered as colon epithelial cells switch from normal to the transformed state. We are confident that being able to recognise these changes has the potential to be used as a biomarker and prognostic marker in the early detection of colon cancer. Real Time PCR was utilised to compare the gene expression profile of 9 PKC isozymes in matched normal and cancer tissue samples. We found differential expression of the conventional PKCs, with PRKCB (the gene coding for PKC Beta II) being significantly downregulated in the cancer tissue of over 90% of patients (p&amp;lt;0.01,n = 22). This change was closely linked to the progression of the disease. Using tissue microarrays, we also demonstrated significant alterations in both epithelial and stromal levels of PKC Beta II between the patients normal and diseased tissue. The level of PKC Beta II in the diseased tissue was significantly decreased across patients (p&amp;lt;0.01,n = 164) and we associate the decreased expression with tumour stage. In conclusion we suggest that differential expression of PKC Beta II may be an important mechanism regulating the change to the transformed phenotype in colon cancer. Citation Format: Catríona M. Dowling, James J. Phelan, Mary Clare Cathcart, Brian Mehigan, Paul McCormick, Tara Dalton, John C. Coffey, Jacintha O'Sullivan, Patrick A. Kiely. Correlating the expression of protein kinase C isozymes with the transformed phenotype in colorectal cancer. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 2136. doi:10.1158/1538-7445.AM2015-2136
Studies on the Nutritive Value of Milk. II. The Effect of Pasteurization on Some of the Nutritive Properties of Milk.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PHYSIOLOGIC EFFECTS OF EXERCISE IN THE TROPICS
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal