tbuckley/cabot-search huggingface dataset:
Evidence of person-to-person transmission within a family cluster of novel coronavirus infections, United Kingdom, February 2013
Authors: Collective The Health Protection Agency (HPA)
Journal: Eurosurveillance (2013)

In February 2013, novel coronavirus (nCoV) infection was diagnosed in an adult male in the United Kingdom with severe respiratory illness, who had travelled to Pakistan and Saudi Arabia 10 days before symptom onset. Contact tracing identified two secondary cases among family members without recent travel: one developed severe respiratory illness and died, the other an influenza-like illness. No other severe cases were identified or nCoV detected in respiratory samples among 135 contacts followed for 10 days.
Prevention and treatment of toxic shock syndrome: a retrospective look
Authors: B. B. Dan
Journal: JAMA (1984)

Five years ago, the medical community was first notified of the sudden emergence of what appeared to be a new and extraordinary illness.<sup>1</sup>Since that time, the Centers for Disease Control has received reports of more than 2,500 cases of what we now know as "toxic shock syndrome" (TSS). Investigations quickly uncovered that TSS had a peculiar predilection for young women during their menses and that recurrences of the illness arose in subsequent menstrual periods.<sup>2</sup>Studies of the menstrually associated cases demonstrated that the disease in these women was associated with the use of tampons and with vaginal infection with<i>Staphylococcus aureus</i>.<sup>3</sup> Despite its recent recognition, descriptions of staphylococcal illnesses indistinguishable from TSS have appeared for more than 50 years.<sup>4-7</sup>Studies of nonmenstrual TSS have shown that these cases too are associated with staphylococcal infection.<sup>8,9</sup>The vast majority of all recovered TSS staphylococcal isolates are
The Importance of Basic Science
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Residency Overwork
Authors: Michael Green
Journal: Annals of Internal Medicine (1996)

Letters15 May 1996Residency OverworkMichael Green, MDMichael Green, MDUniversity of Wisconsin Medical School; Madison, WI 53792Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-124-10-199605150-00039 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Dr. Myerson, a resident in internal medicine, presents a credible argument in favor of working long hours. She claims that long working hours are optimal for patients and education because they promote continuity of care while teaching dedication, commitment, and perseverance. What this argument ignores, however, is that fatigue can impair reasoning while leading to unprofessional attitudes such as cynicism and anger toward patients [1]. Further, if continuity and education were the true primary goals of long work hours, then residents would presumably devote more time to direct patient care and education during overnight shifts. In fact, they ...References1. Green MJ. What (if anything) is wrong with residency overwork? Ann Intern Med. 1995; 123:512-7. Google Scholar2. Knickman JR, Lipkin M, Finkler SA, Thompson WG, Kiel J. The potential for using non-physicians to compensate for the reduced availability of residents. Acad Med. 1992; 67:429-38. Google Scholar3. Lurie N, Rank B, Parenti C, Woolley T, Snoke W. How do house officers spend their nights? N Engl J Med. 1989; 320:1673-7. Google Scholar4. Petersen LA, Brennan TA, O'Neil AC, Cook EF, Lee TH. Does house-staff discontinuity of care increase the risk for preventable adverse events? Ann Intern Med. 1994; 121:866-72. Google Scholar Author, Article, and Disclosure InformationAffiliations: University of Wisconsin Medical School; Madison, WI 53792 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 May 1996Volume 124, Issue 10Page: 934KeywordsBehaviorFatigueForecastingPatientsReasoningResidency Issue Published: 15 May 1996 CopyrightCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Corrigendum
Journal: The American Journal of Bioethics (2015)

This article refers to:Islamic Goals for Clinical Treatment at the End of Life: The Concept of Accountability Before God (Taklīf) Remains Useful: Response to Open Peer Commentaries on “Ethical Obligations and Clinical Goals in End-of-Life Care: Deriving a Quality-of-Life Construct Based on the Islamic Concept of Accountability Before God (Taklīf)”
More on the Doctor's Anguish
Authors: John Hansen-Flaschen
Journal: Annals of Internal Medicine (1993)

Letters1 August 1993More on the Doctor's AnguishJohn Hansen-Flaschen, MDJohn Hansen-Flaschen, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-3-199308010-00032 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I commend Miles Edwards and Susan Tolle for their deeply personal account of disconnecting a conscious patient from a mechanical ventilator [1]. By way of recounting a related story, I would like to comment on the authors' insistence that they did not kill their patient.Not long ago, I discontinued mechanical ventilation of a patient and longstanding friend, in accordance with her advance directive, after she had suffered for years because of disabling chronic obstructive lung disease. The woman did not die as anticipated; instead, she regained consciousness and lingered on, bedbound and continuously dyspneic at rest. ...REFERENCE1. Edwards MJ, Tolle SW. Disconnecting a ventilator at the request of a patient who knows that he will then die: the doctor's anguish. Ann Intern Med. 1992; 117:254-6. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1993Volume 119, Issue 3Page: 252-253KeywordsConsciousnessDrugsDyspneaFearHomicideLungsMorphineVentilators Issue Published: 1 August 1993 CopyrightCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Controlled Human Exposure to Methyl Tertiary Butyl Ether in Gasoline: Symptoms, Psychophysiologic and Neurobehavioral Responses of Self-Reported Sensitive Persons
Authors: Nancy Fiedler, Kathie Kelly-McNeil, Sandra Mohr, Paul Lehrer, Richard E. Opiekun, ChiaWei Lee, Tom Wainman, Robert Hamer, Clifford Weisel, Robert Edelberg, Paul J. Lioy
Journal: Environmental Health Perspectives (2000)

The 1990 Clean Air Act mandated oxygenation of gasoline in regions where carbon monoxide standards were not met. To achieve this standard, methyl tertiary butyl ether (MTBE) was increased to 15% by volume during winter months in many locations. Subsequent to the increase of MTBE in gasoline, commuters reported increases in symptoms such as headache, nausea, and eye, nose, and throat irritation. The present study compared 12 individuals selected based on self-report of symptoms (self-reported sensitives; SRSs) associated with MTBE to 19 controls without self-reported sensitivities. In a double-blind, repeated measures, controlled exposure, subjects were exposed for 15 min to clean air, gasoline, gasoline with 11% MTBE, and gasoline with 15% MTBE. Symptoms, odor ratings, neurobehavioral performance on a task of driving simulation, and psychophysiologic responses (heart and respiration rate, end-tidal CO(2), finger pulse volume, electromyograph, finger temperature) were measured before, during, and immediately after exposure. Relative to controls, SRSs reported significantly more total symptoms when exposed to gasoline with 15% MTBE than when exposed to gasoline with 11% MTBE or to clean air. However, these differences in symptoms were not accompanied by significant differences in neurobehavioral performance or psychophysiologic responses. No significant differences in symptoms or neurobehavioral or psychophysiologic responses were observed when exposure to gasoline with 11% MTBE was compared to clean air or to gasoline. Thus, the present study, although showing increased total symptoms among SRSs when exposed to gasoline with 15% MTBE, did not support a dose-response relationship for MTBE exposure nor the symptom specificity associated with MTBE in epidemiologic studies.
Novel clinical and molecular findings in Spanish patients with nevoid basal cell carcinoma syndrome
Authors: N. Alonso, J. Cañueto, S. Ciria, E. Bueno, I. Palacios‐Alvarez, M. Alegre, C. Badenas, A. Barreiro, L. Pena, C. Maldonado, M.V. Nespeira‐Jato, C. Peña‐Penabad, A. Azon, M. Gavrilova, I. Ferrer, O. Sanmartin, L. Robles, A. Hernandez‐Martin, M. Urioste, S. Puig, L. Puig, R. Gonzalez‐Sarmiento
Journal: British Journal of Dermatology (2018)

Nevoid basal cell carcinoma syndrome (NBCCS), also known as Gorlin Syndrome, affects only 1 in 56 000 people. It is usually inherited from a parent with the condition and affects both males and females equally (autosomal dominant inheritance). People with NBCCS may show characteristic features such as extra fingers or toes, irregular ribs, an unusually shaped face and large head. Tumours sometimes develop, particularly jaw cysts and basal cell carcinomas (BCCs) of the skin from which the syndrome is named. NBCCS is caused by mistakes (mutations) in a gene called PTCH1 located on the long arm of chromosome 9. PTCH1 acts as a brake on a set of chemical processes in cells called the Hedgehog (HH)/GLI signalling pathway. In NBCCS, mutations inactivate PTCH1 allowing excessive Hedgehog signalling. This loss of control results in the abnormal bones and tumours. Within an affected family, people with the same genetic mutation can have very different abnormalities. This group from Spain studied 22 unrelated Spanish people with NBCCS to see if they could discern any relationship between specific clinical abnormalities and specific genetic mutations. BCCs were very common, occurring in 96% of patients with 43% having more than 50; 77% had jaw cysts. Two abnormalities had not previously been recognised in NBCCS: double uterus and a benign nerve tumour. They found 19 PTCH1 mutations that had not previously been reported. However, they could not find any pattern relating the type of mutation to the clinical abnormalities. Presumably other factors besides the PTCH1 mutation causes the clinical features.
Abstract P058: Hostility Attitudes &amp; Prevalent or Future Diabetes Among Black Adults: The Jackson Heart Study
Authors: Tsikata Apenyo, Samuel Ridout, Tracey Taveira, Wen-Chih Wu
Journal: Circulation (2017)

Background: Hostility and diabetes mellitus (DM) share common determinants such as obesity, tobacco use and physical inactivity. Thus, we investigated their unstudied relationship at baseline and at 10 yrs after among Black adults in the Jackson Heart Study (JHS), a group with high rates of DM. Hypothesis: Hostility and its subdomains (hostile affect, aggressiveness, and cynicism) correlate with DM at baseline or at 10 yrs after. Methods: From the JHS cohort (n=5301), we studied 3,434 Blacks who completed the Cook-Medley Hostility Scale. Hostility was measured in 3 subdomains: hostile affect, cynicism and aggressiveness; higher scores correlated with higher hostility levels. Participants were stratified into quartiles based on the hostility scale. Frequency of DM at baseline or at 10 yrs after was compared amongst quartiles and tested for trend. Using multivariate logistic regression, we studied the cross-sectional relationship between quartiles of levels of hostility and the combined outcome of presence of diabetes at present or at 10 yrs after, adjusting for known confounders of DM. Subanalyses were conducted at each hostility domain level. Results: Our population was 35% men with a mean age of 54.3 (SD 12.6) yrs. Quartiles were associated with age, BMI, smoking, hA1c, caloric intake, hs-CRP, and alcohol intake (all p&lt;0.05). Overall hostility quartiles and its subscales correlated with DM at baseline but only the subdomains of hostile affect and cynicism correlated with DM at 10 yrs. When prevalent or DM at 10 yrs were assessed as a combined risk, individuals in the last quartile of the hostile affect subdomain was associated with a higher DM risk versus first quartile (Table). Similar link was not found in other subdomains. Conclusions: Hostility attitude was associated with DM risk factors and prevalent DM. Only 2/3 of the hostility subdomains correlated with DM at 10 yrs after. Individuals from the last quartile of hostile affect subdomain was related to a higher risk of prevalent or DM at 10 yrs when compared to the first quartile.
Role of the Oxidative DNA Damage Repair Gene OGG1 in Colorectal Tumorigenesis
Authors: Christopher G. Smith, Hannah West, Rebecca Harris, Shelley Idziaszczyk, Timothy S. Maughan, Richard Kaplan, Susan Richman, Philip Quirke, Matthew Seymour, Valentina Moskvina, Verena Steinke, Peter Propping, Frederik J. Hes, Juul Wijnen, Jeremy P. Cheadle
Journal: JNCI Journal of the National Cancer Institute (2013)

Biallelic inherited mutations in the oxidative DNA damage repair gene MUTYH predispose to colorectal adenomas and colorectal carcinoma (CRC) with high penetrance. We investigated whether rare inherited variants in other oxidative DNA damage repair genes predisposed to CRC. Single marker association analyses were assessed under an allelic model with Bonferroni correction for multiple testing. All statistical tests were two-sided. A rare inherited nonsynonymous variant in OGG1 (Gly308Glu), the functional partner of MUTYH, was over-represented in case patients with advanced CRC compared with population-based control subjects (n = 36 of 2142 case patients vs n = 15 of 2175 control subjects in the training phase, P = 1.8×10−3; and n = 22 of 1005 case patients vs n = 8 of 1389 control subjects in the validation phase, P = 4.8×10−4; P = 1.4×10−5 combined; odds ratio = 2.92, 95% confidence interval = 1.80 to 4.74). Glycine at residue 308 was highly conserved through evolution, and the glutamic acid substitution was predicted as likely to interfere with function. Biallelic inherited and somatic OGG1 mutations were rarely observed in OGG1Gly308Glu carriers, nor did we find any associated somatic mutator phenotype. These data suggest that OGG1Gly308Glu may act as a low-penetrance allele that contributes to colorectal tumorigenesis.
COLLATERAL ORGANIZATIONS.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bureau of Investigation
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Gynecologic Endocrinology
Authors: Irwin E. Thompson
Journal: JAMA (1976)

This large volume, with 48 contributors and nine major categories of hormonal physiology and function, covers virtually all aspects of hormonal problems in woman. The first three sections are largely devoted to the physiology of the hypothalamic-pituitary-ovarian axis and related clinical problems. Hypothalamic-hypophyseal control mechanisms, including gonadotropin-releasing factors and steroid-feedback-control mechanisms are discussed in some detail, together with a lucid presentation of current concepts of the hormonal physiology of the ovary. Included in these sections are chapters on the hormones of the placenta and thyroid-gonadal interrelationships. There is also an extensive chapter on the radiologic aspects of gynecologic endocrinology. The recent advances in the understanding of amenorrheas with hyperprolactinemia and the usefulness of bromergocryptine in related infertility are not discussed in adequate detail, no doubt because of the paucity of data available at the time of preparation of the book. In section 4, therapy of menstrual disorders is outlined in
Patient Care after Percutaneous Coronary Artery Interventions
Authors: Gregory J. Dehmer
Journal: Annals of Internal Medicine (1998)

Letters1 April 1998Patient Care after Percutaneous Coronary Artery InterventionsGregory J. Dehmer, MDGregory J. Dehmer, MDUniversity of North Carolina; Chapel Hill, NC 27514Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-7-199804010-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Dr. Rashdan cites the results of a recent trial in which probucol was used to limit restenosis after angioplasty [1]. This report was published on 7 August 1997, well after our manuscript had been accepted and typeset for publication. We did not include the abstract form of this study because the number of probucol recipients reported in the abstract was small (n = 91) and the reduction in restenosis (35.2% in the placebo group and 22.6% in the probucol group; P = 0.055) was of borderline significance [2]. Experience with restenosis trials has repeatedly shown that drugs, thought ...References1. Tardif JC, Cote G, Lesperance J, Bourassa M, Lambert J, Doucet S, et al. Probucol and multivitamins in the prevention of restenosis after coronary angioplasty. Multivitamins and Probucol Study Group. N Engl J Med. 1997; 337:365-72. Google Scholar2. Tardif JC, Cote G, Lesperance J, Bourassa M, Bilodeau J, Doucet S, et al. Prevention of restenosis by pre and post-PTCA probucol therapy. A randomized clinical trial [Abstract]. Circulation. 1996; 94(Suppl I):I-91. Google Scholar3. McCullough PA, Wolyn R, Rocher LL, Levin RN, O'Neill WW. Acute contrast nephropathy after coronary intervention: incidence, risk factors, and relationship to mortality [Abstract]. J Am Coll Cardiol. 1996; 27(Suppl A):304A-5A. Google Scholar4. McCullough PA, Wolyn R, Rocher LL, Levin RN, O'Neill WW. Acute renal failure after coronary intervention: incidence, risk factors, and relationship to mortality. Am J Med. 1997; 103:368-75. Google Scholar Author, Article, and Disclosure InformationAuthors: Gregory J. Dehmer, MDAffiliations: University of North Carolina; Chapel Hill, NC 27514 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1998Volume 128, Issue 7Page: 599-600KeywordsAngioplastyCholesterolDatabasesDeath ratesDrugsLipidsMedical dialysisPatientsPeer reviewStatistical data ePublished: 15 August 2000 Issue Published: 1 April 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Preventing Emphysema
Authors: M. J. Friedrich
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal