tbuckley/cabot-search huggingface dataset:
A critical balance between endothelins and nitric oxide regulates portal resistance after endotoxin pretreatment . Johns Hopkins Medical Institutions, Baltimore, Maryland
Journal: Hepatology (1995)

Production of tissue inhibitors of matrix metalloproteinases (TIMPs), a family of secreted proteins with inhibitory actions on matrix metalloproteinases (MMPs), is up-regulated following nerve injuries and is suggested to have protective effects against MMP-mediated tissue damages. To clarify the extracellular signals involved in TIMP production in the brain, the effects of endothelins (ETs), a family of vasoconstricting peptides, were examined. I.c.v. administration of 500 pmol/day Ala1,3,11,15-ET-1, an ETB receptor agonist, increased the level of TIMP-1 mRNA in rat hippocampus, caudate-putamen and cerebrum. Ala1,3,11,15-ET-1 increased the level of TIMP-3 mRNA in the cerebrum, but not in the hippocampus or caudate-putamen. TIMP-2 mRNA was not affected in these brain regions. Ala1,3,11,15-ET-1 also stimulated the production of TIMP-1 and TIMP-3 proteins in the cerebrum. Immunohistochemical observations in the hippocampi of Ala1,3,11,15-ET-1-infused rats showed that NeuN-positive neurons and glial fibrillary acidic protein–positive astrocytes were immunoreactive for TIMP-1. In the cerebrum, astrocytes had TIMP-1 and TIMP3 reactivity, but neurons did not. In rat cultured astrocytes, both 100 nM Ala1,3,11,15-ET-1 and ET-1 increased the mRNA levels and protein release of TIMP-1 and TIMP-3 mRNAs. The effects of ET-1 on astrocytic TIMP-1 and TIMP-3 mRNAs were inhibited by BQ788, an ETB antagonist. These findings indicate that activation of brain ETB receptors causes production of TIMP-1 and TIMP-3, and suggest the involvement of astrocytes in ET-induced TIMP production.
Organellar clusters formed by mitochondrial-rough endoplasmic reticulum associations: An ordered arrangement of mitochondria in hepatocytes*1
Authors: J CASCARANO
Journal: Hepatology (1995)

Our objective was to determine if mitochondrialrough endoplasmic reticulum (mt-RER) associations provide for an ordered arrangement of mitochondria in the cell. If such an ordered arrangement exists, it might be manifested by grouping of mitochondria according to size and biochemical properties. Liver homogenate was subjected to rate zonal centrifugation for fractionating mitochondrial clusters. These clusters were then examined for morphological and biochemical characteristics. Scanning electron microscopy (SEM) showed that (1) mitochondria were held together in clusters by rough endoplasmic reticulum, (2) clusters consisted of mitochondria of comparable size, and (3) a 45-fold difference in average mitochondrial volume existed between the organelles of the fastest and slowest sedimenting clusters. Transmission electron microscopy (TEM) affirmed that all of the organellar clusters examined were mitochondria associated with rough endoplasmic reticulum. Cytochrome oxidase and mitochondrial DNA were found to be proportional to mitochondrial volume, indicating that these components were synthesized in proportion to increases in volume. Conversely, succinic dehydrogenase and ornithine carbamoyl transferase were increased disproportionately (2.9-fold and six-fold, respectively) with increase in mitochondrial volume. It is evident from this biochemical heterogeneity that clusters composed of larger mitochondria differ functionally from clusters of smaller mitochondria. The size-ordered arrangement suggests that this organization is in some way related to the biogenesis of hepatocyte mitochondria. It is also conjectured that the biochemical heterogeneity is a consequence of addition of selected proteins (e.g., succinic dehydrogenase and carbamoyl transferase) to mitochondria in a developmental process as they mature into larger organelles.
420P Sequential use of everolimus and sunitinib in treating WHO grade 1 and 2 pancreatic neuroendocrine tumors–retrospective multi-center study in Taiwan
Authors: C-T. Liu, L-T. Chen, Y-Y. Chen, J-S. Chen, Y-L. Su, W-C. Chou, C-H. Lu, F-C. Ku, M-H. Chen, Y-S. Shan
Journal: Annals of Oncology (2016)
THE WHOLESOMENESS OF SUBSOIL WATERS.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Vasoactive intestinal peptide in cirrhotic rats: Hemodynamic effects and mesenteric arterial receptor characteristics
Authors: S Lee
Journal: Hepatology (1996)

Vasoactive intestinal peptide (VIP) blood levels in cirrhosis are elevated, but its hemodynamic and receptor characteristics remain unclarified. We aimed to quantify VIP receptor characteristics in mesenteric arteries, plasma VIP concentration by radioimmunoassay (RIA), and the hemodynamic effects of VIP infusion in bile duct-ligated (BDL) cirrhotic and sham-operated control rats. Mesenteric arterial membranes were prepared by ultracentrifugation, and receptor characteristics were studied using 125I-labeled VIP as a radioligand. For the hemodynamic study, there were four groups: cirrhotic and sham-operated rats were infused with either VIP (50 ng/kg/min for 15 minutes) or equivolumic isotonic saline. Regional blood flows were measured in conscious rats with radioactive microspheres. Receptor studies showed high-and low-affinity binding sites for VIP, which had similar equilibrium dissociation constants (binding affinities) and receptor densities for both the cirrhotic and control rats. Plasma VIP concentrations were significantly elevated in the cirrhotic rats. In both cirrhotic and sham-operated rats, VIP infusion produced plasma levels approximately twofold to threefold increased over the basal levels observed in cirrhotic rats. In cirrhotic rats, VIP infusion did not affect any hemodynamic parameter, whereas in the sham-operated rats VIP infusion significantly increased the mesenteric visceral blood flow. These results show that the hyporesponsiveness to VIP in cirrhotic rats is not attributable to receptor downregulation, implying postreceptor alterations. This suggests that VIP may not play a major role in the maintenance of splanchnic hyperemia in cirrhosis.
VERY LATE STENT THROMBOSIS AFTER REVASCULARIZATION WITH EVEROLIMUS AND SIROLIMUS–ELUTING STENTS: FROM THE SORT OUT IV TRIAL
Authors: Lisette Okkels Jensen, Per Thayssen, Hans–Henrik Tilsted, Michael Maeng, Anne Kaltoft, Evald Christiansen, Knud Hansen, Morten Madsen, Jan Ravkilde, Leif Thuesen, Jens Lassen
Journal: Journal of the American College of Cardiology (2013)
A Randomized Phase I Trial of Melphalan + Bortezomib as Conditioning for Autologous Transplant for Myeloma: The Effect of Sequence of Administration.
Authors: Sagar Lonial, Jonathan Kaufman, Amelia A. Langston, Leonard T. Heffner, Claire Torre, Mary J. Lechowicz, Christopher Flowers, Stephanie McMillan, Michael Arnold, Ned K. Waller
Journal: Blood (2007)
LAW &amp;amp; MEDICINE
Authors: —Angela Roddey Holder
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Severity of liver disease in liver transplantation recipients with hepatitis C virus infection: Relationship to genotype and level of viremia
Authors: S Zhou
Journal: Hepatology (1996)

Infection with hepatitis C virus (HCV) genotype 1b has been reported to be associated with more severe posttransplantation liver disease than infection with non-1b genotypes. To address this issue, we evaluated the outcome in 124 patients who underwent liver transplantation for chronic HCV infection. The HCV genotype and/or serotype responsible for infection was determined by four different methods. HCV RNA was detected in serum samples by polymerase chain reaction (PCR) amplification, and quantified by branched DNA assay. Disease severity was expressed as a histological score (which included grading of portal inflammation, lobular activity, fibrosis, and cytopathic changes). Median duration of histological follow-up was 25 months (range 1-75 months). Genotype was assignable in 112 (92.5%) patients. Genotypes responsible for infection were as follows: 1a = 32.2%, 1b = 27.3%, 2a = 7.4%, 2b = 8.3%, 3a = 14%, and mixed infection (more than one subtype) = 3.3%. Level of viremia, alanine aminotransferase (ALT), aspartate aminotransferase (AST), bilirubin, and total histological score were not significantly different in patients infected with type 1b compared with patients infected with other genotypes. While duration of histological follow-up was greater in patients infected with type lb versus other types (P = .02), by univariate and multivariate analysis neither HCV genotype (lb versus others), level of viremia nor duration of histological follow-up were associated with disease severity. Moreover, there was no significant difference in the actuarial graft survival in patients infected with type lb compared with that of patients infected with non-lb types (82% and 87% at 3 years, respectively). Reanalysis using HCV genotype 1 showed no association with disease severity, graft survival, and patient survival. We conclude that HCV genotype 1 and subtype 1b are not associated with disease severity or graft survival in liver transplantation recipients.
Functional and Ultrastructural Abnormality of Platelets in Ehlers-Danlos Syndrome.
Authors: Heihachiro Kashiwagi
Journal: Annals of Internal Medicine (1965)

s1 May 1965Functional and Ultrastructural Abnormality of Platelets in Ehlers-Danlos Syndrome.Heihachiro Kashiwagi, M.D., Jeanne M. Riddle, Ph.D., J. P. Abraham, M.D. (Associate), Boy Frame, M.D., F.A.C.P.Heihachiro Kashiwagi, M.D.Search for more papers by this author, Jeanne M. Riddle, Ph.D.Search for more papers by this author, J. P. Abraham, M.D. (Associate)Search for more papers by this author, Boy Frame, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-5-1084_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA bleeding tendency is one of the salient features of Ehlers-Danlos syndrome. An altered vascular and supportive tissue structure has previously been considered to be the cause. Observations by others have demonstrated variable coagulation abnormalities on isolated cases, but a consistent defective pattern has not been recognized.The present study is based on a hemostatic survey with ultrastructural study of platelets on four patients with classic Ehlers-Danlos syndrome. Three of the patients (all unrelated) demonstrated a normal plasma clotting time, normal partial thromboplastin test, and an abnormal prothrombin consumption time, suggestive of a functional defect of platelets. Electron microscopic study,... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Heihachiro Kashiwagi, M.D.; Jeanne M. Riddle, Ph.D.; J. P. Abraham, M.D. (Associate); Boy Frame, M.D., F.A.C.P.Affiliations: Detroit, Michigan PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1965Volume 62, Issue 5Page: 1084-1085KeywordsBlood plasmaElectron microscopyHemorrhageHemostaticsPlatelets ePublished: 1 December 2008 Issue Published: 1 May 1965 PDF downloadLoading ...
A NEW USE FOR COVER GLASS FORCEPS
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Rereading Osler
Journal: BMJ (1984)

The Heart and Rheumatic Disease is a book for committed readers: skimmers and dippers will find it heavy going.This is the second in an unusual series, as the editors have chosen to consider how the heart and its various structures are affected by the different rheumatic diseases.The authors come from a variety of specialties and the chapters are devoted to pericarditis, myocardial involve- ment, conduction disorders, the aortic and the mitral valves, pulmonary and systemic hypertension, coronary vasculitis, current day rheumatic fever, and, finally, diagnostic techniques.The anatomical/physiological format works wonders for some chapters and is less successful for others.The chapters on pericarditis, myocardial involvement, and conduction disorders are excellent and on their own justify the purchase of this elegantly produced and well illustrated book.Problems with the format start with the chapters on aortic and mitral valve disease.In parts they are excellent but they become repetitious.They provide useful epidemiological data on the prevalence of all forms of valvular disease and are descriptively useful, but fall down by giving elementary detail on clinical examination and investigation at medical student level.A certain amount of confusion arises when some chapters also include connective tissue disorders such as Hurler's disease, Marfan's syndrome, and osteogenesis imperfecta, and, as usual, Libman Sacks, which is not clinically important, gets more attention than infective endocarditis.
THE BALANTIDIUM COLI (STEIN) IN INTESTINAL DISEASES.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lymphoblastic leukaemia.
Authors: J. M. Bennett, E. S. Henderson
Journal: BMJ (1969)

serum potassium was 4-45 mEq/litre, and this rose steadily thereafter to 5-1 mEq/litre one week later.His urinary potassium excretion likewise fell to 25 mEq/24 hours with restora- tion of the pH to normal.
应激对表皮屏障功能的影响
Authors: M. Maarouf, C.L. Maarouf, G. Yosipovitch, V.Y. Shi
Journal: British Journal of Dermatology (2019)

皮肤由三层组成。它们是表皮、真皮和皮下脂肪。表皮是最外层,赋予您皮肤颜色,调节经皮肤的水分丢失和保护身体免受细菌和皮肤刺激物的损伤。 有大量研究显示,来自拥挤、孤独、吸烟、缺乏睡眠、疼痛和婚姻关系紧张的应激可能导致此层短期和长期失去功能。 这项研究旨在评估应激和表皮功能丧失之间的关系。分析了 21 项调查这一关系的研究的结果。它们都是英文研究,规模涵盖小型到大型研究。 应激激素释放的刺激来自于一个脑回路。该研究发现,情绪压力促进此回路,由此导致释放入血液的应激激素数量增多。这减少了表皮层组成成分的产生,从而导致水分丢失增多。 总之,对 21 项研究的回顾显示,情绪压力对表皮屏障功能有负面影响。建议未来研究更多调查现实生活压力,以进一步研究对皮肤的影响。还建议研究可帮助最大程度减少和恢复表皮功能的实用减压治疗,尤其在高危人群中。
RECENT OBSERVATIONS ON YAWS (FRAMBESIA TROPICA)
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Efficacy of catheter ablation in the pulmonary veins: Comparison between different types of atrial fibrillation Koichiro Kumagai, Naomichi Matsumoto, Hideaki Tojo, Hiroo Noguchi, Hideko Nakashima, Naoki Gondo, Keijiro Saku. Fukuoka University Hospital, Fukuoka, Japan
Journal: Journal of the American College of Cardiology (2001)
Impact of ESC+ technology on the hepatic safety profile of GalNAc-delivered, HBV-targeting RNAi therapeutics
Authors: Edward Gane, Christian Schwabe, Jorg Taubel, Anna Bakardjiev, Stephen Huang, Xiao Ding, Lynn Connolly, Phil Pang, Pushkal Garg, Vasant Jadhav
Journal: Journal of Hepatology (2020)
Abstract 18488: Metabolic Modulation of the Diseased Human Lung; A Translational, Novel ex vivo Lung Perfusion Model
Authors: Vikram Gurtu, Adam Kinnaird, Christopher White, Roxane Paulin, Darren Freed, Jayan Nagendran, Evangelos Michelakis
Journal: Circulation (2015)

Introduction: Pulmonary arterial hypertension (PAH) and idiopathic pulmonary fibrosis (IPF) are deadly diseases that often require lung transplantation. Preclinical evidence suggests that mitochondrial suppression underlies the pro-proliferative and anti-apoptotic phenotype of pulmonary artery smooth muscle cells and pulmonary fibroblasts, respectively. Two therapies to improve mitochondrial function are a) dichloroacetate (DCA), an activator of pyruvate dehydrogenase (PDH), the gate-keeping enzyme for glucose oxidation, and b) 4-phenylbutyrate (4-PBA), an inhibitor of endoplasmic reticulum stress, a response that suppresses mitochondrial function during cellular stress. Although these drugs can be studied in vitro or in animals, their metabolic effects on the whole human lung may only by studied through ex vivo lung perfusion (EVLP). Methods: We used a custom-made EVLP system to study explanted, diseased human lungs of patients undergoing lung transplant for PAH (n=2), or IPF (n=4). The bronchi were connected to a ventilator, while a pump-driven system perfused the pulmonary artery (PA) with modified Krebs-Henseleit buffer or STEEN solution™ in recirculation. Lung biopsies were collected to measure mitochondrial respiration (using a Seahorse analyzer) and PDH activity at baseline, and after drug intervention with DCA or 4-PBA for 1 hour. Results: In the PAH lungs, hypoxic pulmonary vasoconstriction, a validated marker of lung health, was absent. However administrating the prostacyclin analogue treprostinil reduced PA pressure by 31.6% (at a level of flow corresponding to the patient’s cardiac output), confirming abnormal but present vasoreactivity in the model. DCA caused a 61.1% increase in oxygen consumption, and a 34-fold increase in PDH activity. In IPF lungs, PBA increased oxygen consumption by 62.0%. Conclusions: EVLP is a feasible model to study the direct effects of drugs on diseased human lungs. Since before-after biopsies are not possible in clinical trials, this is a valuable model to facilitate translation of preclinical therapies to clinical trials. Our results show, for the first time in human lungs, that the metabolic remodeling of the PAH and IPF can be reversed by clinically available small molecules like DCA and 4-PBA.
t(3;11) translocation in treatment-related acute myeloid leukemia fuses MLL with the GMPS (GUANOSINE 5′ MONOPHOSPHATE SYNTHETASE) gene
Authors: Linda D. Pegram, Maureen D. Megonigal, Beverly J. Lange, Peter C. Nowell, Janet D. Rowley, Eric F. Rappaport, Carolyn A. Felix
Journal: Blood (2000)