tbuckley/cabot-search huggingface dataset:
Recent Advances in Community Psychiatry
Authors: Alvin Becker, N. Michael Murphy, Milton Greenblatt
Journal: New England Journal of Medicine (1965)

Programs for Prevention of HospitalizationFour principles of modern community care have been outlined by Lewis.33 The first is that, whenever possible, a patient should be kept in his home community and treated there. Secondly, if hospitalization is necessary, ideally it should be short term, and the patient should return for continuing care on an outpatient basis after the acute phase of his illness. Thirdly, facilities should be provided so that the patient can be seen early in the course of his illness, making it possible to avoid hospitalization in many cases. Fourthly, programs that offer "alternatives to hospitalization" should . . .
Employment after liver transplantation*1
Authors: P ADAMS
Journal: Hepatology (1995)

The objective of this study was to study the factors affecting employment after liver transplantation. The employment status and health status of 203 adult liver transplant recipients was assessed retrospectively in a survey comprising an employment questionnaire, the Sickness Impact Profile (SID), and the Medical Outcomes Survey (MOS). The patient population consisted of all surviving adult patients who had undergone liver transplantation between 1982 and 1992 at our institution and who had survived a minimum of 9 months. Fifty-seven percent of the recipients were employed and 43% of the recipients were unemployed. Eighteen percent of the recipients considered themselves not well enough to work. Other reasons cited for not working in the unemployed patients were early retirement (8%), return to school (3%), family reasons (3%), no work available (3%), and chose not to work (3%). Patient age, duration of disability before transplantation, and type of job before transplantation significantly affected posttransplantation employment status. Health status measurements predicting employment were ambulation, home management, physical functioning, and pain. Older recipients and those who were continuously out of the workforce for several years before transplantation were the least likely to return to gainful employment after liver transplantation. These findings have implications for assessing the success of liver transplantation and the implementation of strategies to fully rehabilitate patients after liver grafting.
Brain and pancreatic metastases: A clinico-pathological comparison of various facets of tumor heterogeneity in renal cell carcinoma - The BRAVE project
Authors: L. Derosa, G.L.e. Teuff, B. Chanez, A. Guida, F. Ruatta, G. Gravis, L. Albiges, B. Escudier
Journal: Annals of Oncology (2016)
HAVE SPERMATOZOA FUNCTIONS OR EFFECTS OTHER THAN FERTILIZATION?
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Incorrect Units
Authors: Anthony Gallagher, Tapan Mehta, David Allison
Journal: JAMA (2018)

In Reply Dr Gallagher and colleagues raise an important and legitimate point about the role of surgical skills potentially explaining the variation in complication rates within bariatric surgery COEs.More importantly, they question the lack of objective assessment of surgical skills as part of the accreditation process.We agree that there may be factors not included in the accreditation program that may influence complication rates. 1 Surgical skill is a good example of such a plausible factor. 2 As mentioned in our article, quality improvement studies are needed to identify factors associated with and ideally causative of improved outcomes. 1 Studies that explore plausible factors such as surgical skills may help explain variation in complication rates within bariatric surgery COEs and improve quality of care.
Dynamics of Hemolysis and Hematologic Aspects in Elliptocytosis
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CNS tumors and exposure to acrylonitrile: Inconsistency between experimental and epidemiology studies
Authors: James J. Collins, Dale E. Strother
Journal: Neuro-Oncology (1999)

Acrylonitrile is a potent CNS tumorigen in rats leading to concern that it may be a tumorigen in humans.There have been 12 epidemiology studies of 37,352 workers exposed to acrylonitrile which evaluate CNS cancers.We summarize and evaluate these epidemiology studies for CNS cancers using the methods of meta-analysis.Our analyses indicate that workers with acrylonitrile exposure have null ndings for CNS cancer (relative risk = 1.1, 95% condence interval 0.8-1.5),which are in stark contrast to the projected risk to humans using the rat ndings (relative risk = 3.5, 95% con dence interval 3.0-4.0).We discuss several explanations for the inconsistency between animal and human ndings, including the possibility that the acrylonitrile-induced rat CNS tumors may not be relevant to humans.Given the rarity of CNS tumors in humans and a lack of understanding of the causal mechanisms of these tumors in rats, however, a more de nitive conclusion will have to await additional experimental and observational data.Nevertheless, the epidemiology evidence indicates that acrylonitrile is not a potent CNS tumorigen.
<i>Circulation</i> : Clinical Summaries
Journal: Circulation (2011)

Atrial fibrillation (AF) is the most common sustained arrhythmia and represents a growing burden on the healthcare system.The prevalence of AF increases with age and has been estimated at 3.8% in persons Ͼ60 years of age and at 9.0% in those Ն80 years of age.Atrial fibrillation is associated with considerable morbidity and mortality, related mainly to increased risk of thromboembolic events and of new-onset or worsening heart failure.Treatment of AF remains controversial.Although rhythm control and rate control strategies seem to provide comparable results, restoration and maintenance of sinus rhythm would be the preferable pathophysiological approach.However, current pharmacological antiarrhythmic therapies have limited efficacy and poor safety profiles, and invasive or surgical treatments are indicated only in a minority of patients and are not free of failure and procedural risks.In this study, we tested the efficacy of n-3 polyunsaturated fatty acids in the prevention of AF recurrences in 199 patients with persistent AF on amiodarone and a renin-angiotensin inhibitor.Participants were randomized to n-3 polyunsaturated fatty acids 2 g/d or placebo followed, after at least 4 weeks, by direct current cardioversion.At 1 year, the probability of maintenance of sinus rhythm was significantly higher in the n-3 polyunsaturated fatty acids group than in the placebo group.Our results indicate that the addition of n-3 polyunsaturated fatty acids 2 g/d in patients with persistent AF and structural heart disease and on amiodarone and a renin-angiotensin inhibitor may exert beneficial effects in the prevention of AF recurrence.See p 1100.
Diseases Affecting the Vulva
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Commentary: the FDA, politics, and the public
Authors: L. Lasagna
Journal: JAMA (1975)

SINCE it was begun in 1907, the Food and Drug Administration (FDA) has often been the center of controversy. Recent scandals in the executive branch of the government have reminded us that public officials are not above either the law or the public they are supposed to serve. It is therefore appropriate that the FDA be responsive to public concerns, and be held accountable when criticism erupts, be it from consumerists, the medical profession, the drug industry, or the Congress. Still, it is also crucial that a regulatory agency not become so embroiled in defensive maneuvers that it loses its ability to serve the public properly. During the last decade, the FDA has been accused both of overregulation and underregulation. Such a situation is not as paradoxical as it might seem. On the one hand, the FDA might be considered culpable if it fails to police drug manufacturers and allows
The use of HIV antibody testing by physicians
Authors: M. D. Decker
Journal: JAMA (1988)

<h3>To the Editor.</h3> —The recent investigation by Henry and colleagues<sup>1</sup>of the clinical use of human immunodeficiency virus (HIV) tests suggests that inappropriate use of this test is alarmingly frequent. Alas, it is unlikely that the charts they reviewed merely reflected deficient documentation rather than deficient practice. Dr Sherer,<sup>2</sup>in his accompanying commentary, eloquently described the dangers of inappropriate use of the test. His admonition to proceed with consent, counseling, confidentiality, and caution is as imperative as it is alliterative. Despite my agreement with Dr Sherer, however, I am troubled by laws that prohibit any HIV testing without prior consent or counseling. I do not want to do harm to my patients by failing to obtain consent or to counsel when those steps are indicated (as they almost always are); but equally, I do not want to do harm to my patients by subjecting them to mandatory but
Car-Bird [Carfilzomib, Clarithromycin(Biaxin®), Lenalidomide/(Revlimid®), Dexamethasone) for Newly-Diagnosed Multiple Myeloma
Authors: Tomer M Mark, Abbe Schickner, John N. Allan, Adriana C Rossi, Roger Pearse, Linda Tegnestam, Karen Pekle, Arthur Perry, Kathleen Pognowski, David Jayabalan, Morton Coleman, Ruben Niesvizky
Journal: Blood (2014)
Abstract 9637: Diverse Geometric Changes Related to Dynamic Left Ventricular Outflow Tract Obstruction Without Overt Hypertrophic Cardiomyopathy
Authors: Jung Jun Cha, Hyemoon Chung, Ki Hyun Kim, Young Won Yoon, Byoung Kwon Lee, Jong Youn Kim, Bum-Kee Hong, Se-Joong Rim, Hyuck Moon Kwon, Eui-Young Choi
Journal: Circulation (2014)

Background: Dynamic left ventricular (LV) outflow tract (LVOT) obstruction (DLVOTO) is not infrequently observed in older individuals without overt hypertrophic cardiomyopathy (HCM). We sought to investigate associated geometric changes and then evaluate their clinical characteristics. Method: A total of 168 patients with DLVOTO, which was defined as a trans-LVOT peak pressure gradient (PG) higher than 30 mmHg at rest or provoked by Valsalva maneuver (latent LVOTO) without fixed stenosis, were studied. Patients with classical HCM, acute myocardial infarction, stress induced cardiomyopathy or unstable hemodynamics which potentially induce transient-DLVOTO were excluded. Results: Their mean age was 71±11 years and 98 (58%) patients were women. Patients were classified as pure sigmoid septum (n=14) if they had basal septal bulging but diastolic thickness less than 15 mm, sigmoid septum with basal septal hypertrophy for a thickness ≥15 mm (n=85), prominent papillary muscle (PM) (n=20) defined by visually large PMs which occluded the LV cavity during systole, or as having a small LV cavity with concentric remodeling or hypertrophy (n=49). The prominent PM group was younger, had a higher S’and lower E/e’ than other groups. In all groups, a higher peak trans-LVOT PG was related to E/e’, right atrial pressure and pulmonary arterial systolic pressure. In multivariate analysis, resting trans-LVOT PG correlated to pulmonary arterial pressure (ß=0.200, p=0.016) after adjustment for E/e’, septal thickness and right atrial pressure. Conclusion: DLVOTO develops for various reasons, and patients with prominent PMs have distinct characteristics. DLVOTO-relieving medication may potentially reduce pulmonary pressure in this group of patients.
Biliary Sludge
Authors: Cynthia W. Ko, Sum P. Lee
Journal: Annals of Internal Medicine (1999)

Letters19 October 1999Biliary SludgeCynthia W. Ko, MD and Sum P. Lee, MD, PhDCynthia W. Ko, MDUniversity of Washington; Seattle, WA 98195 (Ko)Veterans Affairs Puget Sound Health Care System; Seattle, WA 98108 (Lee)Search for more papers by this author and Sum P. Lee, MD, PhDUniversity of Washington; Seattle, WA 98195 (Ko)Veterans Affairs Puget Sound Health Care System; Seattle, WA 98108 (Lee)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-131-8-199910190-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We thank the readers for their insightful and constructive comments on our review. Biliary sludge, or microlithiasis, is an evolving field and therefore generates different and controversial viewpoints. Dr. Baron raises the question of the appropriateness of endoscopic biliary sphincterotomy for patients with biliary sludge. We agree that sphincterotomy is useful as an alternative treatment in selected patients. It is a valid treatment option in patients with sludge and complications, including biliary colic and recurrent pancreatitis, who are not candidates for cholecystectomy. Just like asymptomatic gallstones, asymptomatic biliary sludge should not trigger an automatic response of surgical (or ...References1. Freeman ML, Nelson DB, Sherman S, Haber GB, Herman ME, Dorsher PJ, et al . Complications of endoscopic biliary sphincterotomy. N Engl J Med. 1996;335:909-18. CrossrefMedlineGoogle Scholar2. Lans JI, Geenen JE, Johanson JF, Hogan WJ. Endoscopic therapy in patients with pancreas divisum and acute pancreatitis: a prospective, randomized, controlled clinical trial. Gastrointest Endosc. 1992;38:430-4. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Cynthia W. Ko, MD; Sum P. Lee, MD, PhDAffiliations: University of Washington; Seattle, WA 98195 (Ko)Veterans Affairs Puget Sound Health Care System; Seattle, WA 98108 (Lee) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 19 October 1999Volume 131, Issue 8Page: 631KeywordsAbdominal painBileBile ductsCholecystectomyEndoscopic retrograde cholangiopancreatographyMicroscopyPancreasPancreatitisPatientsSludge ePublished: 15 August 2000 Issue Published: 19 October 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
BAD Phosphorylation Determines Ovarian Cancer Chemosensitivity and Patient Survival
Authors: Douglas C. Marchion, Hope M. Cottrill, Yin Xiong, Ning Chen, Elona Bicaku, William J. Fulp, Nisha Bansal, Hye Sook Chon, Xiaomang B. Stickles, Siddharth G. Kamath, Ardeshir Hakam, Lihua Li, Dan Su, Carolina Moreno, Patricia L. Judson, Andrew Berchuck, Robert M. Wenham, Sachin M. Apte, Jesus Gonzalez-Bosquet, Gregory C. Bloom, Steven A. Eschrich, Said Sebti, Dung-Tsa Chen, Johnathan M. Lancaster
Journal: Clinical Cancer Research (2011)

Despite initial sensitivity to chemotherapy, ovarian cancers (OVCA) often develop drug resistance, which limits patient survival. Using specimens and/or genomic data from 289 patients and a panel of cancer cell lines, we explored genome-wide expression changes that underlie the evolution of OVCA chemoresistance and characterized the BCL2 antagonist of cell death (BAD) apoptosis pathway as a determinant of chemosensitivity and patient survival.Serial OVCA cell cisplatin treatments were performed in parallel with measurements of genome-wide expression changes. Pathway analysis was carried out on genes associated with increasing cisplatin resistance (EC(50)). BAD-pathway expression and BAD protein phosphorylation were evaluated in patient samples and cell lines as determinants of chemosensitivity and/or clinical outcome and as therapeutic targets.Induced in vitro OVCA cisplatin resistance was associated with BAD-pathway expression (P < 0.001). In OVCA cell lines and primary specimens, BAD protein phosphorylation was associated with platinum resistance (n = 147, P < 0.0001) and also with overall patient survival (n = 134, P = 0.0007). Targeted modulation of BAD-phosphorylation levels influenced cisplatin sensitivity. A 47-gene BAD-pathway score was associated with in vitro phosphorylated BAD levels and with survival in 142 patients with advanced-stage (III/IV) serous OVCA. Integration of BAD-phosphorylation or BAD-pathway score with OVCA surgical cytoreductive status was significantly associated with overall survival by log-rank test (P = 0.004 and P < 0.0001, respectively).The BAD apoptosis pathway influences OVCA chemosensitivity and overall survival, likely via modulation of BAD phosphorylation. The pathway has clinical relevance as a biomarker of therapeutic response, patient survival, and as a promising therapeutic target.
Commentaire de travail de N. C. M. van Heel et al., pp. 536
Journal: Endoscopy (2010)

N. C. M. van Heel, J. Haringsma, M. C. W. Spaander, M. J. Bruno, E. J. Kuipers. Rôle des prothèses oesophagiennes dans la prise en charge de la dysphagie par compression extrinsèque
Specific Precipitin Bands in Serology of Histoplasmosis
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Some small for gestational age fetuses have higher risk of late fetal death than others
Journal: BMJ (1998)

Some small for gestational age fetuses have higher risk of late fetal death than othersIn small for gestational age fetuses, without congenital malformations, constitutionally small fetuses-for example twins or the fetuses of short mothers-have been assumed to at lower risk of late fetal death than fetuses affected by conditions such as pre-eclampsia or cigarette consumption.Cnattingius et al (p 1483) tested that assumption in over 1 million births in the Swedish birth register.Overall, late fetal mortality was increased in women who were over 35, nulliparous, smoked, or were <155 cm tall and greatly increased in those with pre-eclampsia, essential hypertension, and twin pregnancies.But in very small for gestational age fetuses death rates were lower in women aged under 35, <155 cm tall, with twins, or with severe eclampsia or hypertension.