tbuckley/cabot-search huggingface dataset:
Genotoxicity, Carcinogenicity, and Mode of Action of the Fried Food Mutagen 2-Amino-3-Methylimidazo[4,5-f]quinoline (IQ)
Authors: John H. Weisburger, William S. Barnes, Charles A. Lovelette, Charles Tong, Takuji Tanaka, Gary M. Williams
Journal: Environmental Health Perspectives (1986)

Because mutagens typified by 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) observed in cooked foods are widely consumed, detailed studies of their biochemical and biological properties including carcinogenicity are most important. IQ induces unscheduled DNA synthesis in liver cells, which when taken together with its powerful mutagenicity in the Salmonella typhimurium test system, predicts carcinogenicity. In female Sprague-Dawley rats, IQ did exhibit potent carcinogenicity for the mammary gland, the ear duct, and to a lesser extent, pancreas and bladder. Data from Japanese laboratories indicate carcinogenicity also to the intestinal tract. Thus, one of the mutagens formed during cooking is a versatile carcinogen that because of extensive human intake requires urgent exploration for specific human cancer risk.
Obesity: A Continuing Enigma
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Concentration and Size of Asbestos in Water Supplies
Authors: James R. Millette, Patrick J. Clark, Michael F. Pansing, James D. Twyman
Journal: Environmental Health Perspectives (1980)

A review of the results of over 1500 asbestos analyses from U.S. water supplies suggests that the majority of water consumers are not exposed to asbestos concentrations in their drinking water over 1 x 10(6) fibers per liter. There are, however, some populations that are exposed to waterborne asbestos concentrations over 10 x 10(6) fibers per liter caused by natural erosion, mine processing wastes, waste pile erosion, corrosion of asbestos cement pipe, or disintegration of asbestos tile roofs running into cisterns. The distribution of fiber sizes in the water is dependent on the source of the fibers. The average length of chrysotile fibers found in an asbestos cement distribution system was 4 micrometers, while the average fiber length of chrysotile fibers contributed to a water supply by natural erosion was 1 micrometer.
THE CHRONIC FORMS OF PURPURA HEMORRHAGICA.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Incorrect Axis Label in Figure
Authors: Ann Navar
Journal: JAMA (2016)

Alison J. Rodger, MD; Valentina Cambiano, PhD; Tina Bruun, RN; Pietro Vernazza, MD; Simon Collins; Jan van Lunzen, PhD; Giulio Maria Corbelli; Vicente Estrada, MD; Anna Maria Geretti, MD; Apostolos Beloukas, PhD; David Asboe, FRCP; Pompeyo Viciana, MD; Félix Gutiérrez, MD; Bonaventura Clotet, PhD; Christian Pradier, MD; Jan Gerstoft, MD; Rainer Weber, MD; Katarina Westling, MD; Gilles Wandeler, MD; Jan M. Prins, PhD; Armin Rieger, MD; Marcel Stoeckle, MD; Tim Kümmerle, PhD; Teresa Bini, MD; Adriana Ammassari, MD; Richard Gilson, MD; Ivanka Krznaric, PhD; Matti Ristola, PhD; Robert Zangerle, MD; Pia Handberg, RN; Antonio Antela, PhD; Sris Allan, FRCP; Andrew N. Phillips, PhD; Jens Lundgren, MD; for the PARTNER Study Group
ACTR-67. PATTERNS OF CARE AND IMPACT ON SURVIVAL OF FIRST SALVAGE THERAPY IN HIGH-RISK GRADE II GLIOMAS FOLLOWING INITIAL TEMOZOLOMIDE
Authors: Alessia Pellerino, Lorenzo Bello, Marco Conti Nibali, Francesco Bruno, Francesca Mo, Edoardo Pronello, Riccardo Soffietti, Roberta Rudà
Journal: Neuro-Oncology (2019)

Abstract BACKGROUND No standard treatment is validated at first progression in high-risk low-grade gliomas, thus the optimal salvage therapy at recurrence and the factors that influence the PFS and OS are being investigated. MATERIAL AND METHODS We evaluated 71 patients with grade II glioma (WHO 2016) who progressed following surgery and initial chemotherapy with TMZ. Thirty-two (45.1%) patients were oligodendrogliomas IDH 1/2 mutated and 1p19q codeleted, 11 (15.5%) were diffuse astrocytomas IDH mutant, and 28 (39.4%) were diffuse astrocytomas IDH wild-type. Median follow up was 144 months (range 23–180). RESULTS Thirty-one patients (43.7%) underwent second surgery, 24 (33.8%) second-line chemotherapy, and 16 (22.5%) radiotherapy with a median PFS of 58 months (IC 95% 49–116). Median PFS was 60 months after second surgery (IC95% 43–116) and chemotherapy (IC95% 51–69), and 38 months after radiotherapy (IC95% 15–64) (p 0.09). No significant benefit in PFS was achieved in oligodendrogliomas undergoing second surgery (60 months) as compared with oligodendrogliomas treated with radiation or chemotherapy (58 months, p 0.11). PFS of astrocytomas IDH wild-type following second surgery (53 months) did not differ from those patients treated with adjuvant treatments (65 months, p 0.28). Median OS from the first salvage therapy was 117 months (IC95% 93 – 123+): 120 months (IC95% 108–140+) after second surgery, 94 months (IC95% 75–117+) after chemotherapy, and 62 months (IC95% 27–112) after radiotherapy (p 0.04). Median OS (123 months, IC95% 106–154) was prolonged in oligodendrogliomas receiving second surgery as compared to those receiving radiotherapy or chemotherapy (93 months, IC 95% 61–112, p 0.07), while median OS in astrocytomas IDH wild-type did not differ between those who received second surgery or radiotherapy or chemotherapy. CONCLUSION Reoperation as first salvage treatment in grade II gliomas seems to offer a probability of a longer OS, and this could hold true especially for oligodendrogliomas.
Foreign Medical Graduates
Authors: Henry R. Mason
Journal: JAMA (1974)

Thousands of foreign medical graduates initially attracted by residency training opportunities in the United States have become permanent additions to the US medical manpower pool. While the numbers migrating from Western countries have remained constant, there continues to be an upsurge of physicians migrating from the Far East and Middle East. Once qualified for practice, they tend to settle in the more populous metropolitan states; proportionately, they hold more full-time staff positions in state and county hospitals. These foreign graduates seek specialty training and board certification in about the same proportion as their American counterparts. (<i>JAMA</i>229:428-430, 1974)
GOVERNMENT SERVICES
Journal: JAMA (1946)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
RURAL SANITATION
Authors: PLATT W. COVINGTON
Journal: JAMA (1926)

In discussing rural sanitation it seems appropriate to consider, first, conditions affecting public health in rural districts as compared with urban; second, the unit best suited for rural health administration and, third, the cost of rural health administration. <h3>CONDITIONS AFFECTING PUBLIC HEALTH IN RURAL DISTRICTS AS COMPARED WITH URBAN</h3> The great advancement in preventive medicine during the last quarter of a century has led to the employment of a trained and full-time personnel in the health department of most of our larger cities. Many of these have accomplished notable results in reducing their community's death rate from preventable diseases. The concentration of a large population over a small area, making possible the occurrence of alarming epidemics, has made the necessity of maintaining such departments obvious. The greater financial resources of such communities have kept the cost within reasonable limitations. In rural districts, however, as the result of less apparent need
Triplets.
Authors: J. H. Weaver
Journal: JAMA (1903)

Hope, Ark., May 19, 1903. <h3>To the Editor:</h3> —May 14 I delivered Mrs. M. of triplets, two girls, one boy. The weights of the two girls were 5½ and 6 pounds and of the boy 6½ pounds. They are all hale and hearty and at this time are doing nicely. Mrs. M., who is the mother of four other children, is also doing nicely. She had the easiest time of any of her confinements.
Changes in serum potassium response to succinylcholine following trauma
Authors: A. A. Birch
Journal: JAMA (1969)

Serum potassium response to an intravenous dose of 100 mg of succinylcholine chloride was investigated in 59 patients with moderate to severe trauma including burns of more than 30%, bilateral amputations, multiple fractures, and widespread missile wounds. Each patient served as his own control prior to succinylcholine administration. Serum potassium determinations were made both before, and three minutes after, succinylcholine infusion. This group of patients did not show a significant rise in serum potassium level until approximately one week after injury, at which time there was noted a progressive rise in the potassium level following succinylcholine infusion. At approximately the third week, three patients with severe injuries showed a rise in serum potassium level which was capable of causing cardiac arrests. The above change did not occur if five minutes prior to succinylcholine administration, the patient was given a 6-mg, intravenous dose of tubocurarine chloride.
British Association of Dermatologists Dermatology and Genetic Medicine (BADGEM)
Authors: M.-L Lovgren, G Ryan, D Walsh, M Ogboli, K Molloy, S Unter, C Moss, A Dubois, R Martin, A Thormann, F Cunningham, H Firth, S Hunt, N Rajan
Journal: British Journal of Dermatology (2020)

Genomes Project (100kGP) was set up in 2013 to establish the use of whole-genome sequencing in the National Health Service to identify genetic mutations in people with rare genetic diseases and cancer.All specialists were invited to recruit patients, but many dermatologists were deterred by confusing and time-consuming processes.Nonetheless, interesting results are now emerging and we report our experience from a large children's hospital.Ninetytwo individuals with rare genetic skin disease and no known mutation were recruited from 71 families.To date (31 January 2020) variants have been identified in the following conditions and genes (numbers of families in brackets): autosomal recessive congenital ichthyosis [ARCI; 10 families: TGM1 (2), CYP4F22 (1), PNPLA1 (1), CERS3 (2), ABCA12 (2), FLG (1), NIPAL4 (1)]; epidermolysis bullosa [EB; 16 families: LAMA3 (1), KLHL24 (1), DST (1), KRT6C (1), COL7A1 (1), COL17A1 (1), EXPH5 (2), CST (1), no variant found (5), variant of unknown significance (VUS) (2)]; ectodermal dysplasia [ED; 16 families: PVRL1 (1), EDA (1), WNT10A (1), EDAR heterozygous (2), PORCN (1), no variant found (9), VUS (1)]; nonsyndromic hypotrichosis [four families: LIPH (1), no variant found (3)]; palmoplantar keratoderma [10 families: KRT6C (1), DSP (1), SLURP1 (1), no variant found (6), VUS (1)]; pustular psoriasis [one family: IL36RN (1)]; ultra-rare monogenic [14 families: telangiectasia RASA1 (1), ATR (1), neurocutaneous PIGH (1) ST3GAL5 (1), piebaldism KIT (2), cutis laxa ELN (1), dyschromatosis KITLG (1), no variant found (4), VUS (2)].Overall, 38 families (54%) have received a definitive diagnosis.Several rare genotypes have emerged.Clinicopathological multidisciplinary team discussion in some cases led to a revised clinical diagnosis, including EB revised to pachyonychia congenita (KRT6C variant), EB simplex revised to junctional EB (COL17A1 variant) and ARCI revised to ichthyosis vulgaris (FLG variant).Conversely, three initially negative genetic reports were revised when queried by clinicians: in a patient with classical Goltz syndrome, subsequent array analysis showed complete PORCN deletion, while in two families causative mutations were not initially reported because they appeared not to segregate with disease until careful clinical review revealed subtle clinical signs in a parent who self-reported as unaffected, one with a RASA1 mutation and the other an EDAR mutation.Work continues on the 33 families (46%) with no definitive answer.Good communication between Genomic Medicine Centres and clinicians is essential to maximize the benefit from 100kGP.
Significant inter- and intra-laboratory variation in Gleason grading of prostate cancer: A nationwide study of 35,258 patients in The Netherlands
Authors: R.N. Flach, P. Willemse, I.A. Deckers, C. Van Dooijeweert, B.B.M. Suelmann, P.J. Van Diest, R.P. Meijer
Journal: European Urology (2021)
Observations on Skin Cancer Among Refinery Workers
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A SANATORIUM FOR CONSUMPTIVE CHILDREN
Authors: E. C. Bedford
Journal: BMJ (1905)

<h3>ABSTRACT</h3> The goal of this study was to learn what properties of sound affect human focus the most. Participants (N=62, 18-65y) performed various tasks while listening to either no background sound (silence), popular music playlists for increasing focus (pre-recorded songs), or personalized soundscapes (audio composed in real-time to increase a specific individual’s focus). While performing tasks on a tablet, participants wore headphones and brain signals were recorded using a portable electroencephalography headband. Participants completed four one-hour long sessions, each with different audio content, at home. We successfully generated brain-based models to predict individual participant focus levels over time and used these models to analyze the effects of various audio content during different tasks. We found that while participants were working, personalized soundscapes increased their focus significantly above silence (p=0.008), while music playlists did not have a significant effect. For the young adult demographic (18-36y), silence was significantly less effective at producing focus than audio content of any type tested (p=0.001-0.009). Personalized soundscapes enhanced focus the most relative to silence, but professionally crafted playlists of pre-recorded songs also increased focus during specific time intervals, especially for the youngest audience demographic. We also found that focus levels can be predicted from physical properties of sound, enabling human and artificial intelligence composers to test and refine audio to produce increases or decreases in listener focus with high temporal (millisecond) precision. Future research includes real-time adjustment of sound for other functional objectives, such as affecting listener enjoyment, calm, or memory.
Convention Allergy Symposium Date and Time Wrong
Journal: JAMA (1975)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mercury and Monomethylmercury: Present and Future Concerns
Authors: William F. Fitzgerald, Thomas W. Clarkson
Journal: Environmental Health Perspectives (1991)

Global atmospheric changes carry the potential to disrupt the normal cycling of mercury and its compounds. Acid rain may increase methylmercury levels in freshwater fish. Global warming and increased ultraviolet radiation may affect the global budget of methylmercury, including its formation and degradation in both biotic and abiotic environments. In this article we review current knowledge on mercury and monomethylmercury with regard to their environmental fate and the potential for human health effects. Recent findings indicate that atmospheric Hg deposition readily accounts for the total mass of Hg in fish, water, and sediment of Little Rock Lake, a representative temperate seepage lake in north-central Wisconsin. It is strikingly evident that modest increases in atmospheric Hg loading could lead directly to elevated levels in the fish stock. It is doubtful, given the experimental limitations in many recent studies, that the temporal pattern for Hg emissions, for background atmospheric Hg concentrations, and for changes in Hg depositional fluxes has been identified. Thus, the present and future questions of whether the environmental impact is of local, regional, or hemispheric significance remain. Contemporary investigations must address these important questions. Human exposure to methylmercury in the United States is probably increasing due to increased consumption of fish and fish products. A recent epidemiological investigation indicates high susceptibility to brain damage during prenatal exposures to Hg. An important objective for future investigation is to establish the lowest effect level for human exposure to methylmercury.
Ascorbic acid and the common cold. Evaluation of its efficacy and toxicity
Authors: M. H. Dykes
Journal: JAMA (1975)

We reviewed the clinical data relating to the efficacy and safety of pharmacologic doses of ascorbic acid in the prevention and treatment of the common cold. Although one study tentatively supports the hypothesis that such doses of ascorbic acid may be efficacious, a second study by the same group did not confirm the significant findings, and no clear, reproducible pattern of efficacy has emerged from the review of all the evidence. Similarly, there is currently little adequate evidence on either the presence or the absence of serious adverse reactions to such doses of ascorbic acid, although many such reactions have been hypothesized. The unrestricted use of ascorbic acid for these purposes cannot be advocated on the basis of the evidence currently available. (<i>JAMA</i>231:1073-1079, 1975)
Biofeedback for Patients With Raynaud's Phenomenon
Journal: JAMA (1979)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal