tbuckley/cabot-search huggingface dataset:
Toxic chemical story ends happily
Authors: W. A. Check
Journal: JAMA (1979)

One neurotoxic industrial chemical that you will probably not hear much about is dimethylaminopropionitrile (DMAPN). Reason: Only one month elapsed between the initial discovery that DMAPN causes severe bladder dysfunction in industrial workers and removal of this chemical from production. Responsible for the quick action were the physicians who established DMAPN's toxicity, the Occupational Safety and Health Administration (OSHA), and the companies that manufactured and used the substance. At the recent American Academy of Neurology meeting in Chicago, two participants described the investigations. The first patient was seen in March 1978 in Baltimore by Alan Pestronk, MD, assistant professor of neurology at the Johns Hopkins University School of Medicine. The patient had difficulty urinating and some sensory loss in the hands and feet. Three days later one of Pestronk's colleagues, James Keogh, MD, assistant professor of medicine at Johns Hopkins, saw a patient with similar symptoms. While discussing the two
Abstract 2944: 64-Slice Computed Tomography Coronary Angiography in Patients with High, Intermediate or Low Pre-test Probability of Significant Coronary Artery Disease
Authors: Willem B Meijboom, Carlos A van Mieghem, Nico R Mollet, Francesca Pugliese, Annick C Weustink, Niels van Pelt, Gabriel P Krestin, Pim J de Feyter
Journal: Circulation (2007)

Objectives We assessed the usefulness of 64-slice CT coronary angiography (CTCA) to detect or rule out coronary artery disease (CAD) in patients with various estimated pre-test probabilities of CAD. Background The pre-test probability of the presence of CAD may impact on the diagnostic performance of CTCA. Methods 64-slice CTCA (Siemens Sensation 64, Germany) was performed in 254 symptomatic patients. Patients with heart rates ≥65 bpm received beta-blockers before CTCA. The pre-test probability for significant CAD was estimated by type of chest discomfort, age, gender, traditional risk factors and defined as high (≥71%), intermediate (31–70%) and low (≤ 30%). Significant CAD was defined as the presence of at least one ≥ 50% coronary stenosis on quantitative coronary angiography which was the standard of reference. No coronary segments were excluded from analysis. Results The estimated pre-test probability of CAD in the high (N:105), intermediate (N:83) and low (N:66) group was 87%, 53% and 13%, respectively. The diagnostic performance of the CT scan was different in the three subgroups. The estimated post-test probability of the presence of significant CAD after a negative CT scan was 17%, 0%, and 0%, and after a positive CT scan 96%, 88% and 68%. Conclusions CTCA is useful in symptomatic patients with a low or intermediate estimated pre-test probability of having significant CAD, and a negative CT-scan reliably rules out the presence of significant CAD. CTCA does not provide additional relevant diagnostic information in symptomatic patients with a high estimated pre-test probability of CAD.
Clinical grand reounds: The many facets of hemophilia
Authors: Carol K. Kasper, M. Therese Southgate
Journal: JAMA (1974)

<h3>Protocol</h3> THE patient was born in 1949 into a family where his maternal grandfather and a cousin were already known to have hemophilia. The patient hemorrhaged after circumcision, and the diagnosis of severe, classic hemophilia was made. During childhood, the boy had a typical pattern of hemorrhages into various joints and soft-tissue areas and was treated with whole plasma at another facility. Because of his hemophilia, his mother was anxious about permitting normal play, but his father encouraged it and asked that the boy take the responsibility for setting his own limitations. <h3>School History.—</h3> He began public school at age 5, but when the school physician became aware that the boy had hemophilia, he tried to arrange transfer to a school for the handicapped. The parents and the boy's private physician successfully appealed this decision before the school board, and the boy was allowed to remain in school when the
Evaluation of Mechanical Prototype Machines for Continuous Separation of Respirable Cotton Dust Fractions
Authors: Lloyd B. DeLuca
Journal: Environmental Health Perspectives (1986)

The original cotton particulates analyzer used stationary screens to separate aerodynamically the coarse and fine dust fractions from small samples of cotton. By replacing stationary with rotary screens that were continuously cleaned, larger supplies of respirable dust were obtained without interruption. A ginned and a waste cotton were used to test two methods of separation: a rotating 38-micron screen and a tandem rotating 710- or 38- micron screen and cyclone. The fine dust fractions from both systems were captured on filters and examined gravimetrically, by Coulter counter, and scanning electron microscope. The dust passing 38 micron stationary or rotary screens contained particles of 15 micron maximum diameter whereas dust from the 710-gmm rotary screen and tandem cyclone exhibited particles of 10 micron maximum diameter and lint fragments. Dust fractions with particles less than 10 micron diameter and free of lint were obtained with a 38-micron rotary screen and tandem cyclone.
Palliative first-line treatment with weekly high-dose 5-fluorouracil (5-FU) and sodium folinic acid (s-FA) (AIO-schedule) as 24h-infusion plus biweekly oxaliplatin (ox) in patients with definitively nonresectable metastatic colorectal cancer (CRC) following secondary (sec) metastatic resection: An interdisciplinary phase II trial
Authors: H. Albrecht, A. Wein, K. Wolff, V. Brueckl, C. Meier, N. Ostermeier, G. Maennlein, E. G. Hahn, U. Reulbach, W. Hohenberger, F. Boxberger
Journal: Journal of Clinical Oncology (2008)

15064 Background: In an interdisciplinary phase II trial performed from 1995–97 and based on a 5-FU monotherapy (AIO schedule) it was possible to achieve both a sec. metastatic resection after downsizing in 9 patients (17%) and a R0 resection offering curative option in 6 patients (11%) out of a total collective of 53 treated patients (Wein et al, Ann Oncol 2001). The objective of this phase II trial is to verify whether a combination therapy based on ox may improve the curative option in terms of a sec. metastatic resection in a patient cohort with identical inclusion - and exclusion criteria. Methods: Prospective evaluation of 44 pts.; trial start: Jan/13/1998; palliative chemotherapy: ox (Eloxatin, 85 mg/m2 i.v. as a 2h-infusion (inf.); d 1, 15, 29 qd 57) followed by 5-FU (2,000 mg/m2 i.v. as a 24h- inf.; d 1, 8, 15, 22, 29, 36 qd 57) and s-FA (Oncofolic, 500 mg/m2 i.v. as a 24h-inf.; d 1, 8, 15, 22, 29, 36 qd 57) via miniature pump system. Results: Last date of evaluation: Nov/30/07; primary tumor localisation with local R0 resection: coecum: 4.4%; colon asc: 6.7%; flex hep 2.2%; colon transv: 2.2%; colon desc: 2.2%; sigma: 31.1%; rectum: 51.1%; median age: 63 years; men/women: 75.6/24.4%; ECOG 0/1/2: 40.0/48.9/11.1 %; chemoth. appl: total number: 789; higher grade tox. (G 3+4): leucopenia: 0%; diarrhea 15.5%, nausea 2.2%; vomiting 6.7%; hand-foot-syndrome 2.2%; mucositis 0%; fever/infection 4.4%; no higher grade neurotoxicity; response: PR: 43.2%; SD: 36.4%; PD: 15.9%; not evaluable: 4.5%; tumor control (CR, PR, SD): 79.6%; sec. metastatic resection: R0: 24.4%; R2 8.9%; TTP: 8,7 months. Conclusions: Combination chemotherapy with weekly 5-FU and s-FA (AIO) plus bi-weekly ox on an outpatient basis is an effective palliative treatment schedule offering a high rate of curative metastatic resection with solely low grade toxicity and no higher grade neurotoxic side effects. Final results in terms of median survival remain to be seen, whereas they are certainly influenced by the second-line therapy. No significant financial relationships to disclose.
Fondaparinux in Patients With ST-Segment Elevation Myocardial Infarction
Authors: Frank Hartig, Philipp Eller, Christoph Pechlaner
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
What's hot that the other lot got
Authors: Kathryn Prior
Journal: Thorax (2016)

3362 patients with at least one exacerbation of COPD in the previous year were randomised to a long acting β agonist Indacaterol (LABA) and a Long acting muscarinic agonist (LAMA) Glycopyrronium or LABA Salmeterol and inhaled glucocorticoid fluticasone (doi: 10.1056/NEJMoa1516385).The outcome was annual rate of COPD exacerbation.In the LABA-LAMA group there was an 11% reduction in the exacerbation rate (3.59 vs 4.03; rate ratio, 0.89; 95% CI, 0.83 to 0.96; p=0.003) with comparison to the LABA-steroid group.There was also a longer time to first exacerbation (71 days (95% CI 60 to 82) vs 51 days (95% CI 46 to 57); HR, 0.84 (95% CI 0.78 to 0.91), representing a 16% lower risk; p<0.001).The annual rate of severe exacerbations was lower (0.98 vs 1.19; rate ratio, 0.83; 95% CI 0.75 to 0.91; p<0.001).The exacerbation rate was independent of the blood eosinophil count.The incidence of pneumonia was 3.2% in the LABA-LAMA group and 4.8% in the LABA steroid group (p=0.02).
Music Hath Charms for Care of Preemies
Authors: C. Marwick
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Essential Blepharospasm
Authors: Harry M. Salzer
Journal: JAMA (1971)

<h3>To the Editor.—</h3> Hoyt gives a surgically oriented answer to the treatment of essential blepharospasm. Currently I have under successful control a 68-year-old woman whose blepharospasm began after she was involved in a relatively minor automobile accident. The blepharospasm has been almost completely controlled with thioridazine, diphenylhydantoin with phenobarbital, and chlormezanone. Slight alterations in the dose of thioridazine make a big difference in the severity of the blepharospasm. Any operation for blepharospasm is final, and if overambitious, might be undesirable.
Medicina Clínica, Barcelona
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Some Malignant Bone Tumors Appear Radiosensitive; Others Radioresistant
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 14: Pulmonary Hemodynamics in Neonatal Lambs with Pulmonary Hypertension - Effect of Resuscitation with 21% versus 100% Oxygen
Authors: Satyan Lakshminrusimha, Daniel D Swartz, Sylvia F Gugino, Karen A Wynn, Rita M Ryan, Robin H Steinhorn, James A Russell
Journal: Circulation (2007)

The optimal level of O 2 supplementation during neonatal resuscitation is controversial. We recently published data that resuscitation with 21% or 100% O 2 for 30 min results in similar decreases in pulmonary vascular resistance (PVR) in normal newborn lambs ( Pediatr Res in press) . However, the effect of resuscitation with 21% or 100% O 2 on pulmonary hemodynamics in lambs with in-utero pulmonary hypertension (PH) is not known. Methods: PH was induced in fetal lambs by antenatal ductal ligation at 126 d of gestation (term ~ 145 d). Lambs were delivered 9 d later by C-section and ventilated with 21% O 2 or 100% O 2 for 30 min. Control lambs without PH were ventilated similarly for comparison (n=4 −7 in each group). The lambs were instrumented to measure PVR prior to delivery. After 30 min, lambs with PH were ventilated with 50% O 2 and pulmonary vasodilator responses to inhaled NO 20 ppm were evaluated. Results: PVR was significantly higher in lambs with PH compared to control. The decrease in PVR was similar by 30 min in 21% and 100% O 2 resuscitated control lambs. In contrast, 100% O 2 resuscitation resulted in a significantly greater decrease in PVR in lambs with PH (fig A ). However, 100% O 2 resuscitation impaired subsequent decrease in PVR in response to inhaled NO in both control and PH lambs (fig B ). Conclusions: 100% O 2 resuscitation results in a greater decrease in PVR but impairs subsequent pulmonary vasodilation to NO in lambs with PH. Speculation: Ventilation of PH lambs with 100% O 2 significantly increases lung isoprostane levels ( AJRCCM 2006 174 12:1370 ). We speculate that a similar increase in reactive oxygen species following 100% O 2 resuscitation interferes with the vasodilator response to NO.
Intraoperative death associated with acrylic bone cement. Report of two cases
Authors: E. R. Kepes
Journal: JAMA (1972)

Two cases of sudden death occurred during the insertion of hip prostheses with the use of methyl methacrylate polymer as bone cement. In one case in which an autopsy was performed, widespread marrow emboli were found. Hypotension was also an additional factor in cardiopulmonary collapse.
Angiotensin Infusion: A Screening Test for Renovascular Hypertension?
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fortification of Nonfat Milk Solids With Vitamins A and D
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abdominal Tamponade
Authors: Mary R. Baker
Journal: JAMA (1972)

<h3>To the Editor.—</h3> In the report of the "abdominal tamponade" (<b>217</b>:968, 1971) as a complication of nitrous oxide anesthesia, the author has assumed a convenient cause for the profound hypotension. But, unless the case report was incomplete and did not state that a fifth pneumoperitoneum had been created shortly before the introduction of anesthesia, it is unlikely that there was any air remaining in the peritoneal cavity. Unless a completely insoluble gas had been used to create the pneumoperitoneum four times in three weeks, there would not be 7,500 cc of gas in the peritoneal cavity at the start of anesthesia. Adriani<sup>1</sup>states that nitrogen is resorbed from a closed lung lobule in 16 hours because of the low pressure gradient. Oxygen is resorbed rapidly, usually within 15 minutes. Similar rates of diffusion probably apply to air in the peritoneal cavity. If enough nitrous oxide had diffused into
Utility and Limitations of Claims Data
Authors: James G. Jollis
Journal: Annals of Internal Medicine (1994)

Letters15 June 1994Utility and Limitations of Claims DataJames G. Jollis, MDJames G. Jollis, MDDuke University Medical Center; Durham, NC 27710Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-120-12-199406150-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We agree with Drs. Baron and Barrett that including procedure codes or linking claims records from multiple encounters may enhance the sensitivity of claims data for clinical conditions. The “much better results” they mention, however, have yet to be shown. Recently, Roos and colleagues [1] compared claims data from a single hospitalization with data collected from all medical encounters during the previous 6 months in Manitoba for 677 patients having prostatectomy. Despite the universal nature of the Canadian claims system, the additional data in the “claims history” did not significantly improve its sensitivity for clinically identified conditions, increasing ...References1. Roos LL, Sharp SM, Cohen MM. Comparing clinical information with claims data: some similarities and differences. J Clin Epidemiol. 1991; 44:881-8. Google Scholar2. Brown F. ICD-9-CM Coding Handbook, with Answers. Chicago: American Hospital Publishing, Inc.; 1989. Google Scholar3. Hlatky MA, Califf RM, Harrell FE, Lee KL, Mark DB, Pryor DB. Comparison of predictions based on observational data with the results of randomized controlled clinical trials of coronary bypass surgery. J Am Coll Cardiol. 1988; 11:237-45. Google Scholar4. Green J, Wintfeld N. How accurate are hospital discharge data for evaluating effectiveness of care? Med Care. 1993; 31:719-31. Google Scholar Author, Article, and Disclosure InformationAffiliations: Duke University Medical Center; Durham, NC 27710 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 June 1994Volume 120, Issue 12Page: 1049-1051KeywordsHospitalizationsInformation storage and retrievalMedicareMortalityProstatectomyPulmonary diseasesQuality improvementRandomized trialsSpecificitySurgery ePublished: 15 August 2000 Issue Published: 15 June 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...