tbuckley/cabot-search huggingface dataset:
Biomarkers of Environmental Tobacco Smoke Exposure
Authors: Neal L. Benowitz
Journal: Environmental Health Perspectives (1999)

Biomarkers are desirable for quantitating human exposure to environmental tobacco smoke (ETS) and for predicting potential health risks for exposed individuals.A number of biomarkers of ETS have been proposed.At present cotinine, measured in blood, saliva, or urine, appears to be the most specific and the most sensitive biomarker.In nonsmokers with significant exposure to ETS, cotinine levels in the body are derived primarily from tobacco smoke, can be measured with extremely high sensitivity, and reflect exposure to a variety of types of cigarettes independent of machine-determined yield.Under conditions of sustained exposure to ETS (i.e., over hours or days), cotinine levels reflect exposure to other components of ETS.Supporting the validity of cotinine as a biomarker, cotinine levels have been positively correlated to the risks of some ETSrelated health complications in children
Jaundice as a Presentation of Heart Failure
Authors: R van Lingen, U Warshow, H R Dalton, S H Hussaini
Journal: Journal of the Royal Society of Medicine (2005)

On rare occasions the first manifestation of heart disease is jaundice, caused by passive congestion of the liver or acute ischaemic hepatitis. We looked for this presentation retrospectively in 661 patients referred over fifty-six months to a 'jaundice hotline' (rapid access) service. The protocol included a full clinical history, examination and abdominal ultrasound. Those with no evidence of biliary obstruction had a non-invasive liver screen for parenchymal liver disease and those with suspected heart disease had an electrocardiogram, chest X-ray and echocardiogram. 8 patients (1.2%), bilirubin 31-79 micromol/L, mean 46 micromol/L, had a primary cardiac cause for their jaundice. All had dyspnoea, an increased cardiothoracic ratio on chest X-ray and an abnormal electrocardiogram. The jugular venous pressure was raised in the 3 in whom it was recorded. In 6 patients the jaundice was attributed to hepatic congestion and in 2 to ischaemic hepatitis. All patients had severe cardiac dysfunction. Jaundice due to heart disease tends to be mild, and a key feature is breathlessness. The most common mechanism is hepatic venous congestion; ischaemic hepatitis is suggested by a high aminotransferase.
Conference Time
Authors: John Lister
Journal: New England Journal of Medicine (1952)

Although it is the impression of many Americans that there are fewer medical meetings in Britain than in the United States, this impression is scarcely borne out now, at the height of the present conference season.For the fourth time in a hundred and twenty years the British Medical Association has been holding a joint annual meeting with the Irish Medical Association in Dublin. The President (Dr. P. T. O'Farrell) in his opening address recalled that it was at the first Dublin meeting in 1867 that Joseph Lister delivered his famous address "On the Antiseptic Principle of the Practice of . . .
Council on Physical Therapy
Journal: JAMA (1929)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SEASONAL VARIATIONS IN GROWTH
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Novel functional assessment techniques for geriatric lymphoma patients
Authors: A. B. Siegel, J. M. Fiore, J. C. Ketas, R. R. Furman, C. P. Sison, M. L. Ashe, L. M. Mathews, M. Lachs, M. Coleman, J. P. Leonard
Journal: Journal of Clinical Oncology (2004)

8166 Background: Age over 60 and impaired "performance status" (PS) are adverse prognostic features in the International Prognostic Index (IPI) for lymphoma. However, patients over 60 comprise a heterogeneous population, and commonly used PS measures in oncology are subjective and incomplete. More discriminative tools may provide prognostic information that identify subgroups of older lymphoma patients with differing abilities to tolerate disease and treatment. Methods: Geriatricians have validated several tests which predict mortality and functional decline. We evaluated the performance of NHL outpatients aged 60 or older on 4 of these assessments. The timed "up and go" (UG) measures the time (seconds) needed to stand, walk 3 meters, and sit down. The "functional reach" (FR) measures the distance one can reach forward with a fixed base of support. The Tinetti scale (TGB) measures aspects of gait and balance. The hand grip (HG) measures grip strength with a hand-held meter. The primary objective of this pilot study is to establish the range of scores on these examinations in this patient population. Secondary objectives include correlation of scores with survival, treatment tolerance, and quality of life. Results: The mean age of subjects (N=25) was 70, 13 male (M) and 12 female (F). Five were newly-diagnosed, with 15 having aggressive, and 10 having indolent lymphoma. Twenty had an ECOG PS=1, 2 had PS=0, and 3 had PS=3. Within the largest (PS=1) group, the 4 tests each provided further discriminatory ability to differentiate among subjects. The IRQ/Median (higher values reflect greater variance) was 73.1 for HG, 42.3 for UG, 1.8 for TGB, and 16.8 for FR). M and F differed significantly in both the hand grip (M >F) and TGB (F>M). The HG and UG tests showed the most variability, even when stratified by sex. Conclusions: All of the tests demonstrated a range of scores within the ECOG PS=1 measure, and could be completed in about 5 minutes. Given the potential utility of these measures to discriminate among patients, we plan to prospectively study a larger cohort of older lymphoma patients to determine the ability of these assessments to predict survival, tolerability of therapy, and quality of life. No significant financial relationships to disclose.
Abstract 3462: The Cardioprotective Effects Of The Angiotensin-converting Enzyme Inhibitor Perindopril In Patients With Stable Coronary Artery Disease Are Not Modified By Mild to Moderate Renal Insufficiency: Results From The Europa-trial.
Authors: Jan Jasper Brugts, Eric Boersma, Michel Chonchol, Jaap Deckers, Willem Remme, Michel Bertrand, Roberto Ferrari, Kim Fox, Maarten Simoons
Journal: Circulation (2007)

The cardioprotective effects of the ACE-inhibitor perindopril in patients with stable coronary artery disease are not modified by renal function: Results from the EUROPA-trial. Objective: To examine whether the cardioprotective effects of perindopril are modified by renal function in patients with stable coronary artery disease. Background: A recent study reported that an impaired renal function identified a subgroup of patients with stable coronary artery disease more likely to benefit of ACE-inhibition therapy. In light of the growing interest in tailored-therapy for targeting medications to specific subgroups, remarks on the consistency of the treatment effect by ACE-inhibitors are highly important. Methods: The present study involved 12056 patients with stable coronary artery disease without heart failure randomized to perindopril or placebo. Estimated GFR (eGFR) was calculated using the abbreviated MDRD-equation. Results: Mean eGFR was 76.2 (18.1) ml/min per 1.73 m 2 . During follow-up, the primary endpoint (cardiovascular death, non-fatal myocardial infarction, or resuscitated cardiac arrest) occurred in 454/5761 patients (7.9%) with eGFR ≥ 75 and in 631/6295 patients (10.0%) with eGFR&lt;75. Treatment benefits of perindopril were apparent in both patient groups either with eGFR≥ 75 (HR 0.77; 95%CI 0.64 – 0.93) or eGFR≥ 75 (HR 0.84; 95%CI 0.72– 0.98). We observed no significant interaction between renal function and treatment benefit (Pv=0.47). Using different cut-off points of eGFR at the level of 60 or 90 resulted in similar trends. Conclusion: The treatment benefit of perindopril is consistent and not modified by the level of renal function.
Consultant responsibility
Authors: B W Orchard
Journal: BMJ (1977)

gone and a new system of leadership and decision-making is necessary.Many psychiatrists know that to work in a multidisciplinary team setting does not require the relinquishing of their responsibility and authority.Quite the contrary.In no other situation is skilled leadership more necessary.The intelligent sharing of relevant information and skills in such a setting can be very much to the patient's advantage, leading as it does to action which is carried through with greater insight and motivation just because it was discussed and shared beforehand.I agree that the NHS is crying out for clear medical leadership.But we must ensure that we take our non-medical colleagues with us in a way that recognises their own ability and acknowledges that, from time to time, this may even better our own.
Postmarketing follow-up
Authors: H. Jick
Journal: JAMA (1979)

THERE is a general but strongly held view that, after drugs are marketed, additional epidemiologic information is needed on their clinical effects, particularly adverse effects. This notion is based soundly on the limited size and scope of the clinical experience with a drug before marketing. Recently, considerable interest has been evident in this area and has focused on the term "postmarketing surveillance" (PMS). That the interest is widespread and intense is reflected in the many meetings that have taken place, articles that have been written, and committees that have been formed to consider the designing of large formal systems of PMS.<sup>1-15</sup>Given the diffuse nature of the subject, it is essential to take an objective and informed look at the legitimate needs in this area and to consider practical means of satisfying these needs. Without a clear understanding of the nature of the problems that can be addressed epidemiologically
Author's Name Misspelled
Journal: JAMA (1977)

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Comprehensive outpatient care in rheumatoid arthritis. A controlled study
Authors: S. Katz
Journal: JAMA (1968)

Patients with classical or definite rheumatoid arthritis by American Rheumatism Association (ARA) criteria (peripheral type, functional classes 2 and 3 and anatomical stages 2 and 4), were randomly assigned to treatment and control groups in a study of effectiveness of multidisciplinary clinic and home care. Comprehensive care was supplied by staff of the Arthritis Outpatient Clinic of University Hospitals of Cleveland and by staff of the Visiting Nurse Association of Cleveland. Services were coordinated through regularly held staff conferences. An independent clinical investigation team evaluated changes in function and disease activity. Treatment was beneficial in the following terms: fewer deteriorations in activities of daily living, more numerous improvements and fewer deteriorations in economic dependence, and more improvements and fewer deteriorations in clinical manifestations of disease activity. Of methodologic importance was the demonstration of the feasibility of controlled testing of long-term program effectiveness.
Resident Forum
Authors: Paul V. DeMarco
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PARIS LETTER.
Journal: JAMA (1884)

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Association News
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Operative Treatment of Prolapse and Retroversion of the Uterus.
Journal: JAMA (1907)

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Benign ureteral polyp in the newborn
Authors: D. W. Soderdahl
Journal: JAMA (1969)

A benign ureteral polyp occurred in a newborn girl. We believe it is the youngest occurrence of ureteral tumor reported in the English literature. The patient had a mass in the left upper quadrant of the abdomen. Obstruction in the proximal part of the left ureter was confirmed by a retrograde dye injection into the ureter. A 2.0 × 0.5-cm polyp at the ureteropelvic junction was resected, and a dismemberment pyeloplasty was performed. We believe there is a developmental rather than an acquired basis for this polyp.
Epidermoid cyst of the terminal phalanx of the hand. Case report and brief review
Authors: R. A. Hinrichs
Journal: JAMA (1965)

EPIDERMOID CYSTS of the bony skeleton of the hand and specifically of the phalanges have been periodically described since Sonntag's original report in 1923.<sup>1</sup>Less than 50 cases have been reported in the literature. As it is a comparatively uncommon entity, the addition of a new case and a brief review of the clinical features is considered pertinent. <h3>Report of a Case</h3> A 38-year-old married, oil company employee had crushed his middle three fingers between two pipes while at work on June 30, 1962. Initial treatment consisted of local cleansing and application of a topical ointment but without x-ray examination. The wounds apparently healed uneventfully, but subsequently, the middle-digit nail plate developed a longitudinal fissure and the fingertip was intermittently painful and swollen. Pain was aggravated even by light touch and became progressively worse in the six weeks prior to seeking medical attention on May 7, 1963. Past history
Duplicate publication.
Authors: B. Livesley
Journal: BMJ (1992)

occurred more than seven weeks after his admission for self cutting.During five days of inpatient observation he was wary but coherent and rational.Repeated examination found no psychotic signs.With the ward team's agreement he was discharged into intensive community care, was seen repeatedly at his home and at the daily living programme team's base, managed well, and found a job.Two days after last being seen he suddenly killed a child and revealed previously concealed paranoid delusions.Had he remained an inpatient he could have absconded, avoided outpatient follow up, and become someone for whom district services could disclaim responsibility.Community care teams like the daily living programme team which do assertive outreach, however, continue their re- sponsibility for patients and thus their vulnerability to blame for adverse events.Conclusions from our study await our final report.They will have to balance the clinical and social outcomes, patients' and relatives' satisfaction, risk assessment, and an economic analysis.
Evaluation of the initial care of hypertensive patients
Authors: E. D. Frohlich
Journal: JAMA (1971)

Patterns of patient care were evaluated retrospectively from the records of 994 patients hospitalized at a university hospital, a community hospital, and two Veterans Administration hospitals. Arterial pressure was not obtained by the admitting physician in 26% of the patients; and in those in whom a blood pressure was recorded, it was elevated in 18%. Of 200 patients discharged with the primary diagnosis of hypertension, the history, physical examination, and diagnostic evaluation were clearly inadequate. Thus, unless physician-recognition and adequate evaluation are improved (through education) the practice of massive public health screening programs seems pointless.