tbuckley/cabot-search huggingface dataset:
Cognitive Therapy for Hypertension
Authors: David M. Eisenberg
Journal: Annals of Internal Medicine (1994)

Letters1 January 1994Cognitive Therapy for HypertensionDavid M. Eisenberg, MD, Thomas L. Delbanco, MD, and Thomas C. Chalmers, MDDavid M. Eisenberg, MDBeth Israel Hospital; Boston, MA 02215Harvard School of Public Health; Boston, MA 02215Search for more papers by this author, Thomas L. Delbanco, MDBeth Israel Hospital; Boston, MA 02215Harvard School of Public Health; Boston, MA 02215Search for more papers by this author, and Thomas C. Chalmers, MDBeth Israel Hospital; Boston, MA 02215Harvard School of Public Health; Boston, MA 02215Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-120-1-199401010-00027 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:The criticism by Benson and colleagues that cognitive behavioral therapies should not be critically assessed in isolation misses the point of our analysis [1]. Every trial included in our meta-analysis explicitly sought to document the efficacy, or lack thereof, of one or more cognitive behavioral therapies in the treatment of essential hypertension while controlling for confounding variables or cointerventions.Moreover, the references cited by Benson and colleagues relate to post hoc observations of selected subgroups of patients (for example, “responders” compared with “nonresponders”), useful only for generating hypotheses to be tested in randomized trials. For example, they cite ...References1. Eisenberg DM, Delbanco TL, Berkey CS, Kaptchuk TJ, Kupelnick B, Kuhl J, et al. Cognitive behavioral techniques for hypertension: Are they effective? Ann Intern Med. 1993; 118:964-72. Google Scholar2. Cottier C, Shapiro K, Julius S. Treatment of mild hypertension with progressive muscle relaxation. Predictive value of indexes of sympathetic tone. Arch Intern Med. 1984; 144:1954-8. Google Scholar3. Jacob RG, Shapiro AP, O'Hara P, Portser S, Kruger A, Gatsonis C, Ding Y. Relaxation therapy for hypertension: setting specific effects. Psychosom Med. 1992; 54:87-101. Google Scholar4. McGrady A, Higgins JT Jr. Effect of repeated measurements of blood pressure on blood pressure in essential hypertension: role of anxiety. J Behav Med. 1990; 13:93-101. Google Scholar5. Johnston DW, Gold A, Kentish J, Smith D, Vallance P, Shah D, et al. Effect of stress management on blood pressure in mild primary hypertension. BMJ. 1993; 306:963-6. Google Scholar Author, Article, and Disclosure InformationAffiliations: Beth Israel Hospital; Boston, MA 02215Harvard School of Public Health; Boston, MA 02215 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 January 1994Volume 120, Issue 1Page: 91KeywordsAnxietyBlood pressureExerciseHypertensionProspective studiesRandomized trialsResearch design Issue Published: 1 January 1994 CopyrightCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Assessment of Hepatotoxic Potential
Authors: J. E. Gray
Journal: Environmental Health Perspectives (1976)

Philosophic concepts and pragmatic approaches toward improved understanding of the effect of drugs in the hepatocyte are reviewed. No set pattern of studies is advocated but rather observations are encouraged within the framework of studies that provide for varied exposure of the hepatocyte. Clinical usage should be imitated to provide earliest possible indications of toxicity in man. The need for definitive characterization through utilization of appropriate methodology derived from cross-fertilization of related disciplines is stressed. Both minimal and maximal dose effects should be established. Selected use of electron microscopy has become essential for characterizing responses of the liver to injury. The advantages of the toluidine blue-stained Epon "thick" sections are emphasized. Such observations are used to implement the utility of serial biopsies from the beagle dog prior to and during long-term study of potential hepatic injury. Examples of the critical effects of drug concentration within the hepatocyte are presented.
Effects of hypoglycemic agents on vascular complications in patients with adult-onset diabetes. 3. Clinical implications of UGDP results
Authors: M. G. Goldner
Journal: JAMA (1971)

"Field (clinical) trials are indispensable. They will continue to be an ordeal. They lack glamour, they strain our resources and our patience, and they protract the moment of truth to excruciating limits. Still, they are among the most challenging tests of our skills.... If, in major medical dilemmas the alternative is to pay the cost of perpetual uncertainty, have we really any choice?"<sup>1</sup> The clinical trial of the effect of hypoglycemic agents on the vascular complications of diabetes mellitus conducted by the University Group Program (UGDP) for the past ten years bears witness to the truthfulness of the above quotation. The hypothesis that control of the blood glucose level prevents or delays the vascular complications of diabetes has been supported so far only by evidence which is largely conjectural.<sup>2</sup>Such a relationship can be documented only with prospective study of patients randomly assigned to treatment regimens that differ
MICROBES INMILK.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Should functional renal scans be obtained prior to upper abdominal radiation for pancreatic cancer?
Authors: Grace Blitzer, Susan Tsai, Mohammed Aldakkak, Robert Hellman, Douglas B. Evans, Kathleen K. Christians, Ben George, Paul S. Ritch, William Adrian Hall, Beth Erickson
Journal: Journal of Clinical Oncology (2017)

442 Background: Upper abdominal irradiation for pancreas cancer is given in close proximity to the radiation sensitive kidneys. While contemporary 3D and intensity modulated radiation therapy (IMRT) can decrease the total dose of radiation delivered to the kidneys; these plans may potentially exceed the established kidney dose constraints, especially if one kidney is providing most of the renal function. Less than 10% of the general population is estimated to have asymmetrical kidney function. Functional kidney scans using MAG3 clearance can give information about the contribution of each kidney to total renal function. We sought to determine if functional renal scans should be used to identify patients with occult renal dysfunction. Methods: Patients with resectable and borderline resectable pancreatic cancer who received abdominal irradiation therapy and had pre-radiation functional renal scans between 2009-2015 were studied. Asymmetrical kidney function was defined as a difference between the two kidneys that was ≥ 40%/60% on a functional renal scan. Serum studies (BUN, Cr, GFR) were routinely obtained pre-simulation. Restaging abdominal CT scans prior to radiation were screened for disparity in kidney size. Medical history that suggested decreased renal function was also collected. Results: Of the 205 patients examined, 24 (11.7%) had asymmetrical kidney function identified on pre-radiation functional renal scans. Of the patients with asymmetrical kidney function, 4 (2%) had a 75%/25% split or greater and 20 (9.7%) had kidney function between 60%/40% and 75%/25%. Elevated Cr or BUN, a GFR &lt; 60, or a past medical history suggesting abnormal renal function were not significantly associated with asymmetrical kidney function. Only six (25%) of patients with asymmetrical kidney function scans had a notable difference in kidney size. Conclusions: In our series, approximately 12% of patients with pancreatic cancer have asymmetrical kidney function not identified by size, serum BUN, Cr, GFR, or a significant past medical history of renal compromise. These results provide important insight for cases when radiation plans may approach or exceed accepted dose constraints for the kidneys.
Viral disease and islet cell dysfunction
Authors: G. R. Monif
Journal: JAMA (1977)

<h3>In Reply.—</h3> I am grateful to both Drs Rhodes and Le for carefully reviewing the guideline-audits on antimicrobial therapy and for their well thought out comments. First of all, I regret that I did not ask Dr Rhodes to proofread the draft when he was a fellow with us in infectious disease. His points are well taken concerning the proper dosage and duration of prophylaxis with rifampin for meningococcal meningitis and the greater importance of accumulation of lincomycin than clindamycin in patients with renal failure. Dr Le's comments regarding compliance by dentists with the American Heart Association's recommendations on antibiotic prophylaxis in patients with valvular heart disease are of great interest. The only comment I can make is that this field is in great intellectual turmoil at this time because of experience of several workers with animal models of experimental endocarditis.<sup>1</sup> I must admit that I was unaware of
Factors Associated with Self-Reported, Pesticide-Related Visits to Health Care Providers in the Agricultural Health Study
Authors: Michael C. R. Alavanja, Dale P. Sandler, Cheryl J. McDonnell, Charles F. Lynch, Margaret Pennybacker, Shelia Hoar Zahm, Jay Lubin, David Mage, William C. Steen, Wendy Wintersteen, Aaron Blair
Journal: Environmental Health Perspectives (1998)

To investigate factors associated with pesticide-related visits to health care providers (i.e., doctor or hospital visits), responses to self-administered questionnaires received from 35,879 licensed restricted-use pesticide applicators participating in the Agricultural Health Study were analyzed. (In Iowa, applicators are actually certified, whereas in North Carolina they are licensed; for ease of reference, the term license will be used for both states in this paper.) The cohort reported a total of more than 10.9 million pesticide-application days. These applications were associated with one or more pesticide-related health care visits by 2,214 applicators (7.0% of the applicator cohort for whom health care visit data were available). The odds of a pesticide-related health care visit were increased for commercial applicators compared to private applicators [odds ratio (OR = 1.77; 95% confidence interval (CI), 1.52-2.06) and for applicators who used insecticides 70 times or more in their lifetime compared to those who used insecticides less frequently (OR = 1.43; CI, 1.26-1.63). After adjusting for the number of applications in a logistic regression model, significantly higher odds of health care visits were observed among North Carolina applicators compared to Iowa applicators (OR = 1.35; CI, 1.17-1.52), among applicators who mixed their own pesticides (OR = 1.65; CI, 1. 22-2.23), and among applicators who personally repaired their pesticide application equipment at least once per year (OR = 1.12; CI, 1.06-1.25). Significantly lower odds were found among female versus male applicators (OR = 0.68; CI, 0.46-0.99) and among applicators who graduated from high school versus those who did not (OR = 0.82; CI, 0.71-0.94 for high school graduates and OR = 0.79; CI, 0.68-0.91 for those with at least some college). Several methods of pesticide application to crops, seed, or stored grain were also associated with significantly elevated odds ratios of health care visits. These observations suggest that several steps can be taken to reduce the number of health care visits resulting from occupational exposure to pesticides. The implications of this pattern of pesticide-related health care visits may have etiologic implications for cancer and other chronic diseases.
AMIGO2, a novel membrane anchor of PDK1, controls cell survival and angiogenesis via Akt activation
Authors: Hyojin Park, Sungwoon Lee, Pravesh Shrestha, Jihye Kim, Jeong Ae Park, Yeongrim Ko, Young Ho Ban, Dae-Young Park, Sang-Jun Ha, Gou Young Koh, Victor Sukbong Hong, Naoki Mochizuki, Young-Myeong Kim, Weontae Lee, Young-Guen Kwon
Journal: The Journal of Experimental Medicine (2015)
LETTER FROM EUROPE.
Authors: James B. Herrick
Journal: JAMA (1894)

<h3>No. III.</h3> Prag, Bohemia, June 28, 1894. <h3>To the Editor:</h3> —A clinic in internal medicine here, differs but very little from one given in our own colleges. One advantage, however, is the fact that the cases have all been under observation for some time before being brought before the class, so that all facts concerning the patient are accurately known; this advantage is also possessed by our own schools where patients are brought from a hospital where clinical data have been obtained, and where the sole dependence for clinical material is not upon the dispensary. It is worthy of note that in every case that comes before the class, not only is the urine most carefully examined but the blood as well,<i>i.e</i>., the blood count is made and the hemoglobin estimated. The Thoma-Zeiss instrument is the one commonly employed here for counting the corpuscles, both white and red,and the
Transatrial Approach to Total Correction of Tetralogy of Fallot
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Persistent hyperparathyroidism caused by incomplete parathyroid resection and a hyperfunctioning parathyroid autograft
Authors: A. M. Spiegel
Journal: JAMA (1983)

A case of familial primary hyperparathyroidism occurred in which persistent hypercalcemia was caused by hyperplastic parathyroid tissue left in the neck and mediastinum after initial surgery and by a hyperfunctioning parathyroid autograft in the forearm. Successful therapy required parathyroid localization and resection of tissue from the neck, mediastinum, and forearm. Parathyroid tissue should be autotransplanted at the time of initial surgery only when total parathyroidectomy is judged likely to have been achieved. (<i>JAMA</i>1983;250:1896-1898)
Value of Biplane Splenoportography
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Essential Blepharospasm
Authors: Karl Ascher
Journal: JAMA (1971)

<h3>To the Editor.—</h3> May I add to the comprehensive answer by Hoyt (<b>215</b>:1509, 1971) concerning essential blepharospasm an item I learned from the study of vitamin-deficient patients? A common complaint of these patients was blinking, not controlled by dark glasses but instantly relieved by riboflavin. Many of these patients consumed an unsatisfactory diet and much alcohol; with improvement in eating and drinking habits, the blepharospasm disappeared. In the following years, I followed the same line with numerous patients. Far from minimizing Hoyt's answer, I think that before neurectomy is considered, an attempt should be made to discontinue alcohol consumption and to give the patient large doses of riboflavin.
Propafenone
Authors: John A. Oates, Alastair J.J. Wood, Christian Funck-Brentano, Heyo K. Kroemer, John T. Lee, Dan M. Roden
Journal: New England Journal of Medicine (1990)

PROPAFENONE HYDROCHLORIDE (Rythmol) is an antiarrhythmic drug that has been extensively used in Europe and has recently been approved for oral use in the United States for the management of ventricular arrhythmias. The drug (2′-[3-(propylamino)-2-(hydroxy)-propoxy]-3-phenylpropiophenone hydrochloride) is a sodium-channel blocker whose kinetics of interaction with cardiac sodium channels are similar to those of flecainide and encainide. Like these agents, propafenone suppresses nonsustained ventricular arrhythmias, whereas its effect is less consistent in patients with sustained ventricular arrhythmias. In addition, propafenone has β-adrenergic—antagonist properties that may be clinically relevant in some patients. Interpreting the relation between its plasma concentration and its action . . .
Psoriatic spondylitis. Association with advanced nongranulomatous upper lobe pulmonary fibrosis
Authors: L. R. Guzman
Journal: JAMA (1978)

We describe the case of a patient with psoriasis, peripheral and axial arthropathy, and upper lobe fibrosis. This association of findings has not, to the best of our knowledge, been described in the past. Pulmonary fibrosis is not found to be more common in people with psoriasis than would be expected in a control Veterans Administration population and, while this association may be coincidental, pulmonary fibrosis in psoriatic spondylitis should be searched for in other patients. (<i>JAMA</i>239:1416-1417, 1978)
PROFESSOR EHRLICH'S VISIT TO CHICAGO.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Other Approaches to Primary Care Training
Authors: J. Thomas Cross
Journal: Annals of Internal Medicine (1994)

Letters15 July 1994Other Approaches to Primary Care TrainingJ. Thomas Cross Jr., MD, MPHJ. Thomas Cross Jr., MD, MPHSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-121-2-199407150-00025 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The articles in the 1 December 1993 Annals [1-3] were timely and of great interest to those of us beginning our careers in internal medicine. Most internists would agree with Drs. Petersdorf and Goitein [2] that “the general internist continues to be the best primary care physician for adults.” They also state that recent gains in family medicine residencies reflect enrollment students' beliefs that they provide more breadth than do the current internal medicine residency.What all three articles failed to address, however, is that we in internal medicine have an excellent answer to this contention. Since ...References1. Federated Council for Internal Medicine. Generating more generalists: an agenda of renewal for internal medicine. Ann Intern Med. 1993; 119:1125-9. Google Scholar2. Petersdorf RG, Goitein L. The future of internal medicine. Ann Intern Med. 1993; 119:1130-7. Google Scholar3. Fletcher RH, Fletcher SW. What is the future of internal medicine? (Editorial) Ann Intern Med. 1993; 119:1144-5. Google Scholar Author, Article, and Disclosure InformationAuthors: J. Thomas Cross Jr., MD, MPH PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPaediatric training for family doctors: principals and practice 15 July 1994Volume 121, Issue 2Page: 153KeywordsGraduate medical educationInpatientsOutpatientsPatientsPediatricsPrimary care physiciansResidencySub-specialty care ePublished: 15 August 2000 Issue Published: 15 July 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...