tbuckley/cabot-search huggingface dataset:
Medical Therapy for Systemic Right Ventricles: A Systematic Review (Part 1) for the 2018 AHA/ACC Guideline for the Management of Adults With Congenital Heart Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines
Authors: Elisa Zaragoza-Macias, Ali N. Zaidi, Nandini Dendukuri, Ariane Marelli
Journal: Circulation (2018)

Patients with systemic morphological right ventricles (RVs), including congenitally corrected transposition of the great arteries and dextro-transposition of the great arteries with a Mustard or Senning atrial baffle repair, have a high likelihood of developing systemic ventricular dysfunction. Unfortunately, there are a limited number of clinical studies on the efficacy of medical therapy for systemic RV dysfunction. We performed a systematic review and meta-analysis to assess the effect of angiotensin-converting enzyme (ACE) inhibitors, angiotensin-receptor blockers (ARBs), beta blockers, and aldosterone antagonists in adults with systemic RVs. The inclusion criteria included age ≥18 years, systemic RVs, and at least 3 months of treatment with ACE inhibitor, ARB, beta blocker, or aldosterone antagonist. The outcomes included RV end-diastolic and end-systolic dimensions, RV ejection fraction, functional class, and exercise capacity. EMBASE, PubMed, and Cochrane databases were searched. The selected data were pooled and analyzed with the DerSimonian-Laird random-effects meta-analysis model. Between-study heterogeneity was assessed with Cochran's Q test. A Bayesian meta-analysis model was also used in the event that heterogeneity was low. Bias assessment was performed with the Newcastle-Ottawa Scale and Cochrane Risk of Bias Tool, and statistical risk of bias was assessed with Begg and Mazumdar's test and Egger's test. Six studies met the inclusion criteria, contributing a total of 187 patients; treatment with beta blocker was the intervention that could not be analyzed because of the small number of patients and diversity of outcomes reported. After at least 3 months of treatment with ACE inhibitors, ARBs, or aldosterone antagonists, there was no statistically significant change in mean ejection fraction, ventricular dimensions, or peak ventilatory equivalent of oxygen. The methodological quality of the majority of included studies was low, mainly because of a lack of a randomized and controlled design, small sample size, and incomplete follow-up. In conclusion, pooled results across the limited available studies did not provide conclusive evidence with regard to a beneficial effect of medical therapy in adults with systemic RV dysfunction. Randomized controlled trials or comparative-effectiveness studies that are sufficiently powered to demonstrate effect are needed to elucidate the efficacy of ACE inhibitors, ARBs, beta blockers, and aldosterone antagonists in patients with systemic RVs.
Providers?
Authors: Robert A. Gutman
Journal: JAMA (1992)

<h3>To the Editor.</h3> —I appreciate the objective approach of Lurie et al<sup>1</sup>to a difficult problem. The authors were appropriately cautious in interpreting results of their study. My principal criticism is of the almost inexplicable tendency of physicians to avoid the use of the word<i>patient</i>when they are writing or speaking of people with an illness. I suppose it is another example of the apparent preference for some physicians to refer to themselves as "providers." I think all of this proceeds from an inappropriate and ill-conceived notion of the relationship between physicians and patients. We have a responsibility to our patients, to our profession, and to ourselves to see these relationships appropriately. Therefore, I urge writers and editors to adhere to original meanings. "Clients" are generally people seeking assistance from attorneys and social welfare agencies.
AFFILIATED UNITS IN THE ARMY MEDICAL DEPARTMENT
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Proceedings of the British Thoracic Society
Journal: Thorax (1983)

in the University of Cambridge BTS smoking withdrawal study: fators assodated with giving up smoking IA CAMPBELL for BTS Research Committee In the British Thoracic Society's smoking withdrawal study 9-7% of 1550 patients successfully gave up smoking.Reasons for wanting to stop smoking, apart from improvement in health, were expense (30%), dislike of addiction (20%) and "dirty habit" (18%).Concern about weight gain was expressed by 41% of men and 59% of women.Men were more successful than women and success in both sexes increased with age.Men with ischaemic heart disease did best (21% success).Married or single men were more likely to give up smoking than divorced or separated men.Patients whose "most important other person" was a non- smoker did better than if such a person smoked.Women who thought they were addicted were less likely to suc- ceed.Confidence in ability to stop smoking for a year was related to successful outcome in men.Mean weight gain in those who were successful was 5-9 kg.Socideconomic group, cigarette consumption, concern about weight gain and health concern were not related to outcome.Of the successes, 50% rated will power as important, and 15% mentioned illness, 13% their families and 7% their doctor.Only 1 % mentioned expense.Failure was most commonly attributed to lack of will power (28%), relief of tension by cigarettes (24%), and addiction (16%).Other smokers in the family and pressure at home were more important in women than men.Proceedings of the British Thoracic Society Controlled trial of six months' chemotherapy in pulmonary tuberculosis JH ANGEL, AR SOMNER, KM CITRON for the BTS Research Committee Two six-month regimens of isoniazid and rifampicin, supplemented for the first two months by strep- tomycin and pyrazinamide (SHRZ6) or by ethambutol and pyrazinamide (EHRZ6), were compared with a nine- month regimen of isoniazid and rifampicin, supplemented
Request for Abstracts
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Electronic journals and duplicate publication. Is a byte a word?
Authors: A. Flanagin
Journal: JAMA (1992)

More than 300 years ago, general medical journals were created to capture in print the proceedings of scientific meetings and discussions and to communicate these proceedings to medical society members.<sup>1,2</sup>Mostly during the last century, these informal collections evolved into today's scholarly, formally peer-reviewed journals, disseminating scientific reports to readers worldwide. We are now witnessing another information evolution—the electronic journal—spreading the scientific word in tiny, invisible bits and bytes. An "electronic journal" transmits information to readers through a computer network. This information, which includes text, tables, and figures, is produced and stored on computers, is read on a video screen, and subsequently can be printed on paper.<sup>3,4</sup>Since one of the goals of an electronic journal is to disseminate information (usually the work of an author) to readers (albeit faster than conventionally printed and mailed paper journals), an electronic journal is merely another medium of publication, and the
Officers and members of the House of Delegates of the American Medical Association
Journal: JAMA (1984)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Excess FSH May Cause Luteoma
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Brain damage at birth. Functional and structural modifications with time
Authors: W. F. Windle
Journal: JAMA (1968)

Brain damage can be caused in many ways. I have been concerned with that resulting from a deficient supply of oxygen during parturition, ie, with asphyxia neonatorum. The magnitude of the role of this as a killing factor has not been determined, although we well know that it can and does maim a not insignificant number of infants every year. Man, it seems, among all the higher animals, has not yet learned how to manage birth without risk of asphyxia. The United States boasts of being the richest and most powerful nation on earth. People of many lands come to our shores to learn our technology and to profit from our developments in medical science. Nevertheless, there are some things in which we lag shamefully behind other countries. Our infant mortality is distressingly high. The number of deaths in infants less than 1 year of age has declined only slightly
ILEUS.
Authors: JOHN B. MURPHY
Journal: JAMA (1896)

<h3>Mechanic ileus.</h3> —In the diagnosis of internal strangulation, no matter from what cause, we have exactly the same symptoms as in strangulated hernia, except the physical signs are different. The symptoms of internal strangulation are as follows: Pain in the abdomen which comes on suddenly, gradually increasing in intensity for the first half hour, followed by nausea and vomiting, and inability to produce bowel movement. If the strangulation be severe, there is an increase in the frequency of the pulse (but as a rule in the early stage the pulse is not accelerated),<i>absence of temperature</i>, absence of tenderness. As the case advances, if the strangulated coil be large, it can be recognized through a moderately thin abdominal wall by its distension; the coil of the intestine leading to it may also be recognized by a circumscribed elevation of the abdominal wall. In twenty-four hours all of these symptoms will
Motor Nerve Conduction Velocity Determination: A Neurodiagnostic Aid
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
UNIVERSAL PHYSICAL TRAINING
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Love Canal revisited
Authors: S. Wolff
Journal: JAMA (1984)

In 1980 the Environmental Protection Agency (EPA) released the results of a pilot cytogenetic study of 36 self-selected residents of the Love Canal area in Niagara Falls, NY. This area had previously been used as a chemical dump site and now could only be regarded as an ecological disaster area. After being told the results of the initial cytogenetic tests performed on their peripheral blood lymphocytes, many of the residents were terrified. Some appeared on national television emotionally bemoaning the "fact" that they now were going to get cancer because their blood cells contained chromosomal aberrations. The issue was so important that the US Department of Health and Human Services sent in a team of extramural experts to look at the data and the report that had led to so much anguish among those tested. The team was not allowed to see the data but did write a statement criticizing
HYPOSPADIAS.
Authors: C. H. MAYO
Journal: JAMA (1901)

Hypospadias of some degree is one of the most common malformations of man. According to Rennes, Kaufman and others this deformity occurs in one of every 350 males. There are several theories as to the cause of this condition. Some claim that from atresia of the urethra there is fetal retention of urine and finally a giving way of the urethra, or that the same result is caused by a delay in the development of the glandular urethra. The most probable is that of Reichel, who states that hypospadias is merely an arrest of development and the degree of deformity is an indication of the period of intrauterine life at which it occurred. Perineal openings develop in the sixth or seventh and glandular from the twelfth to the sixteenth week. The more common variety is the glandular or balanic, in which the urethral opening is situated back of a broad,
GATA-2 Regulates Dendritic Cell Differentiation
Authors: Koichi Onodera, Tohru Fujiwara, Yasushi Onishi, Ari Itoh-Nakadai, Yoko Okitsu, Noriko Fukuhara, Kenichi Ishizawa, Ritsuko Shimizu, Masayuki Yamamoto, Hideo Harigae
Journal: Blood (2015)
HBO: new chambers, some growing pains
Authors: P. Gunby
Journal: JAMA (1981)

Recent years have seen a dramatic increase in the number of hyperbaric oxygenation (HBO) pressure chambers, as well as in the number of patients undergoing therapy in such chambers, say Baltimore researchers. Not only that, some surprising changes in HBO treatment patterns have taken place. There now are at least 93 chambers in the United States, including about 20 in California, says Roy A. M. Myers, MB, ChB, director of hyperbaric medicine, Maryland Institute for Emergency Medical Services Systems. He and University of Maryland colleagues have mailed out a questionnaire in an effort to determine the extent of clinical use of HBO therapy in this country. Not all of the responses have been received yet, Myers says, but he predicts that at least 20 additional chambers will come to light. The projected total represents at least a fourfold increase over the 27 chambers in operation just four years ago. (There
Patient Management
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Free Radical-Mediated Activation of Hydrazine Derivatives
Authors: B. Kalyanaraman, B. K. Sinha
Journal: Environmental Health Perspectives (1985)

Hydrazines are known to undergo oxidative activation in several enzymatic systems in vitro. Free radicals or carbonium ions have been proposed as active intermediates during such activation. The toxic effects elicited by hydrazines have also been linked to free radical-mediated activation. In this report, we have reviewed the identification of organic free radicals from hydrazines by direct ESR and ESR-spin trapping.
Eosinophilic fasciitis following pregnancy
Authors: J. M. Strosberg
Journal: JAMA (1979)

<h3>To the Editor.—</h3> In his original description of diffuse fasciitis with eosinophilia, Shulman<sup>1</sup>noted that several patients showed development of their initial symptoms after exercise, and he suggested that a peculiar response to undue physical exertion may be partly responsible for the condition. Subsequent reports<sup>2,3</sup>(240:451, 1978) have characterized eosinophilic fasciitis as a distinct entity. We report here a case of eosinophilic fasciitis that started after pregnancy. <h3>Report of a Case.—</h3> The patient was a 42-year-old mother of two with a nine-month history of pain, weakness, and swelling of her hands, which interfered with her caring for her baby who was born three months before the onset of her symptoms. She was in good health. She had had one previous, uneventful pregnancy 20 years earlier. She denied dysphagia and Raynaud's phenomenon. She did no regular exercise. The skin of her forearms and her hands was tense and warm.
Table of contents
Journal: Hepatology (2020)

Cover Figure: Huang and colleagues investigated the role of Sestrin 3 (Sesn3) in nonalcoholic steatohepatitis (NASH).In a mouse model, they determined that Sesn3 safeguards against diet-induced NASH by at least two mechanisms: First, Sesn3 interacts with mothers against decapentaplegic homolog 7 (Smad7) to inhibit transforming growth factor β (TGFβ) receptor activity through Smad7-mediated TGFβ receptor dephosphorylation or degradation; Second, Sesn3 can directly interact with Smad3 and inhibit its nuclear translocation.
403TiP CREAM study: Clinical correlation between ipilimumab- Related colitis And intestinal Microbiote in metastatic melanoma patients
Authors: L. Orgiano, A. Dessi, A. Cubeddu, E. Lai, R. Mascia, S. Tolu, V. Palmas, T. Camboni, C. Madeddu, E. Massa, G. Astara, A. Manzin, M. Scartozzi
Journal: Annals of Oncology (2016)