tbuckley/cabot-search huggingface dataset:
The Role of Nickel and Nickel-Mediated Reactive Oxygen Species in the Mechanism of Nickel Carcinogenesis
Authors: Xi Huang, Zhixiong Zhuang, Krystyna Frenkel, Catherine B. Klein, Max Costa
Journal: Environmental Health Perspectives (1994)

Increasing evidence demonstrates that reactive oxygen species (ROS) are implicated in metal carcinogenesis.Exposure of cultured Chinese ham- ster ovary (CHO) cells to several nickel compounds, i.e, NiS, Ni3S2, NiO (black and green), and NiCI2 has been shown to increase oxidation of 2',7- dichlorofluorescin to the fluorescent 2',7-dichlorofluorescein (DCF), suggesting that nickel compounds increased the concentration of oxidants in CHO cells.This fluorescence can be attenuated by addition of exogenous catalase to the extracellular media, indicating that H202 is one of the formed oxidants in this system.Fluorimetric measurements of chromogens following thiobarbituric acid reaction showed that nickel compounds also induce lipid peroxidation with a decreasing potency NiS, Ni3S2>black NiO>green NiO>NiCI2.These results suggest that lipid hydroperoxides may also be produced through the action of nickel in intact cells.MgCI2, an antagonist of Ni-induced DNA strand breaks and cell transformation, has no effect on the formation of DCF fluorescence induced in CHO cells by nickel.The results suggest that nickel is an active inducer of ROS in intact mammalian cells and that the molecular mechanism of nickel carcinogenesis may involve multiple steps of nickel-mediated ROS. -
Developing and evaluating new models of care in hematology.
Authors: Jonathan Sussman, Tom Kouroukis, Jenna Ratcliffe, Karen Running
Journal: Journal of Clinical Oncology (2016)

e21557 Background: The journey of care for patients with hematological cancer from the time of diagnosis can often be five years or longer. During this period, patients frequently visit their hematology team and may not maintain regular appointments with their family doctor. In doing so, patients may leave other non cancer related health issues, unmonitored. As such, we plan to improve patient care by developing new models of care in hematology to address key medical and psychological needs across the trajectory of care. The goal is to facilitate transition to long term care to primary care where appropriate. Methods: Reviewed published literature on shared care and survivorship modeling for other cancers and included key stakeholder discussion. Conducted semi-structured focus groups with a total of 26 participants (patients, caregivers, family doctors) from the Greater Hamilton area in Ontario, Canada. Participants were asked to share their views on drafted models of care for people with hematological cancer. Results: Three models around the trajectory of care were developed (shared, survivorship and engagement). The analysis revealed that patients were willing to have their family doctor take on more routine follow up visits to monitor blood work as long as the results were readily shared with their hematologist. Patients agreed that more visits to their family doctor could only improve their overall health, although some were apprehensive about their family doctor’s abilities to care for them following their cancer diagnosis. Family doctors similarly were unsure how to treat these patients and felt that clear, concise guidelines need to be developed to outline how to properly care for the long term effects of cancer treatments. Conclusions: Many patients would be willing to engage in shared care with their family doctor during their cancer journey if family doctors were more confident in their cancer care abilities and if communication improved between specialty and primary care. Patients felt that shared care would be beneficial to their overall health. Family doctors stressed that care plans are concise and not outside of their scope. Overall, both family doctors and patients felt that the new models of care, once developed, will help to improve patient outcomes.
"Respiratory function and self-reported functional health: EPIC-Norfolk population study". P.K. Myint, R.N. Luben, P.G. Surtees, N.W.J. Wainwright, A.A. Welch, S.A. Bingham, N.J. Wareham, N.E. Day and K-T. Khaw. Eur Respir J 2005; 26: 494-502.
Journal: European Respiratory Journal (2005)
Why Are Physicians So Confused about Acute Heart Failure?
Authors: Milton Packer
Journal: New England Journal of Medicine (2019)

For most of the past 3000 years, physicians believed that all patients with heart failure had acute heart failure. Heart failure was viewed as an episodic disorder — that is, patients were considered to have heart failure when they presented with fluid retention, and they no longer had heart failure after diuresis.1 The chronicity of heart failure was recognized only when invasive and noninvasive measurements showed severe ongoing structural and functional abnormalities between episodes.2 To develop approaches to preventing hospitalizations and minimizing the functional and prognostic consequences of heart failure, clinical investigators needed to focus on the underlying disease process. . . .
Lectures on the Surgery of Childhood
Authors: A. A. Johnson
Journal: BMJ (1860)

IFractures and Dislocations; Congenital Luxation of the 'T'he plan which I have, sletched out in my own mind is, at present, to offer to you sonme practical remarks, illustrated withi cases, on the surgical affectionis of children generally, with a hope tbat, at some tfuture period, I niay be able to take up those of the genito-uritiary organs, and of the other regionis in due succession.But, gentleulen, in the lecture-theatre, a-s in other theatres, the proposedl perform-iiances ar-e not always condtucted to a successful termlination.They ieqiire, in fact, the concurrenicie of the auidience, as well as tile efforts of the performer; and if it is considered hardly regular, on these boards, to express disapprobation as noisily as elsewhere, it may still be demonstrated more quietly, but as effectually, by yotur noni-attendance.The surgical affections of childien may, I thliinl, b1e conve- niently ar ranged as follows:- I. Thllose, CONGENITAL MAT.FORri.dTIONS-IlSilltheterimi in a very broad sense, and including airests of di-cvlopmcintwhich require the attention of tOel sul-geoni.ii.The direct or immediate consequences of INJURIES or ACCIDENTS.III. SURGICAT.DISEASES PROPER, which may follow one or
Kinins — Possible Physiologic and Pathologic Roles in Man
Authors: R. W. Kellermeyer, Richard C. Graham
Journal: New England Journal of Medicine (1968)

Physiologic and Pharmacologic PropertiesKinins were studied and characterized in terms of their physiologic and pharmacologic properties long before their chemical nature was known. Their potent effects on smooth muscles were the first properties to be studied, and, indeed, the name "bradykinin" was applied because of the slow contraction produced in the smooth muscle of the isolated guinea-pig ileum. In spite of certain quantitative differences, the physiologic effects of the various kinins are qualitatively similar and are discussed together in this section.Effects on Isolated Smooth-Muscle PreparationsBradykinin in minute amounts (0.1 mμg per milliliter) causes contraction of the isolated . . .
The American Society of Preventive Oncology
Journal: JNCI Journal of the National Cancer Institute (1985)

The American Society of Preventive Oncology Get access JNCI: Journal of the National Cancer Institute, Volume 75, Issue 6, December 1985, Page 1148, https://doi.org/10.1093/jnci/75.6.1148-a Published: 01 December 1985
Medically unnecessary hospital use in children seropositive for human immunodeficiency virus
Authors: K. Kemper
Journal: JAMA (1988)

Stimulated by reports that some children who are seropositive for human immunodeficiency virus (HIV + ) have been abandoned in the hospital, we studied the extent of, and reasons for, medically unnecessary hospital use at Yale—New Haven (Conn) Hospital among HIV + children. We reviewed inpatient stays for all HIV + children hospitalized through Oct 31, 1987. Hospital days were judged to be unnecessary if they failed to meet any of the criteria on the Pediatric Appropriateness Evaluation Protocol. Among 34 children eligible for the study, 54% of their hospital days were judged medically unnecessary; 59% of the children had at least one such day. Unnecessary use was 100% for one-day stays (all for γ-globulin infusions) and 58% for stays longer than three weeks, with 94% of those unnecessary days being secondary to placement problems. The rate of unnecessary days has declined from 64% of all hospital days in 1983 and 1984 to 30% in 1987 as a result of improved outpatient services and access to foster care. Improved medical and social services could substantially reduce the cost of medically unnecessary hospital care in HIV + children. (<i>JAMA</i>1988;260:1906-1909)
Frontal Headache
Authors: Huan J Chang, Gianna Zuccotti
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Die Tastmassage: Ihre Anwendung und Wirkungsweise bei den Weichteilrheumatismen
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Re: Cytosine Deaminase/5-Fluorocytosine-Based Vaccination Against Liver Tumors: Evidence of Distant Bystander Effect
Authors: Valérie Pierrefite-Carle, Adolfo Gavelli, Nicole Brossette, Patrick Baqué, Daniel Benchimol, André Bourgeon, Pascal Staccini, Bernard Rossi
Journal: JNCI Journal of the National Cancer Institute (2000)
Shall we continue to climb?
Authors: R. E. McAfee
Journal: JAMA (1986)

For over 30 years, the American Medical Association (AMA) through its policies, programs, and publications has continued to alert the public to the medical consequences of the use of tobacco. This issue of<i>JAMA</i>, the third issue devoted to the problem of smoking, signifies the importance of this public health responsibility as seen by organized medicine. Despite this and similar activities that have had modest success in presenting public information regarding the health consequences of tobacco use, the following facts are still with us: One thousand deaths per day in the United States are attributed to the effects of tobacco. There are 1 million new smokers per year in this country, the majority of whom represent young America. The Surgeon General continues to issue warnings regarding the urgency of this No. 1 public health problem. In excess of $2 billion is spent annually by the tobacco industry to promote their
Incorrect Wording
Authors: William Shrank, Natasha Parekh
Journal: JAMA (2020)

Jonathan S. Steinberg, MD; Vitaliy Shabanov, MD; Dmitry Ponomarev, MD; Denis Losik, MD; Eduard Ivanickiy, MD; Evgeny Kropotkin, MD; Konstantin Polyakov, MD; Pawel Ptaszynski, MD; Boris Keweloh, MD; Christopher J. Yao, MPH; Evgeny A. Pokushalov, MD, PhD; Alexander B. Romanov, MD
Effect of Polybrominated Biphenyls on Hepatic Excretory Function in Rats and Mice
Authors: S. Z. Cagen, J. E. Gibson
Journal: Environmental Health Perspectives (1978)

The purpose of this investigation was to determine the influence of polybrominated biphenyls (PBBs) on hepatic excretory function in developing and adult rats and mice. Prenatal or postnatal dietary exposure to PBBs (50 ppm in diet of pregnant or lactating mother or in diet of rat weanlings) resulted in elevated liver weight in developing rats. In 15-day-old rats that had been treated with PBBs increased liver weight correlated to enhanced ouabain transport from plasma into bile. Liver weight was also elevated in 21, 35, and 49-day-old rats exposed to PBBs, but this effect was not associated with stimulation of ouabain transport in these animals. However, adult rats fed 100 ppm PBBs for two weeks had significantly lower plasma concentrations of sulfobromophthalein (BSP) and increased biliary excretion of BSP, when compared to controls. PBBs-fed adult rats also excreted a greater percentage conjugated BSP (BSP-GSH) into bile. Two week dietary treatment of 100, 150, and 200 ppm PBBs resulted in enhanced initial disappearance of indocyanine green (ICG) from plasma of adult mice. However, dietary doses of 100 and 200 ppm PBBs to adult mice was not associated with enhanced capacity for ouabain excretion. In contrast, treatment with PBBs through the mother's diet (50 ppm) resulted in an almost twofold increase in cumulative ouabain excretion in 15-day-old mice. The results suggest that PBBs stimulate hepatic drug elimination in rats and mice, but the magnitude of the effect is dependent on age and transported compound.
References and Reviews
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Population-Based Analysis of Temporal Perioperative Complication Rates After Minimally Invasive Radical Prostatectomy
Authors: Jan Schmitges, Quoc-Dien Trinh, Firas Abdollah, Maxine Sun, Marco Bianchi, Lars Budäus, Kevin Zorn, Paul Perotte, Thorsten Schlomm, Alexander Haese, Francesco Montorsi, Mani Menon, Markus Graefen, Pierre I. Karakiewicz
Journal: European Urology (2011)
Correction: How can we best prolong life? Benefits of coronary risk factor reduction in non-diabetic and diabetic subjects
Journal: BMJ (1993)

created to facilitate mobility and mobility is of value."20Strategies which reduce the need for car travel or substitute car travel with safer forms of transport would substantially reduce population death rates.2'Thus deaths per vehicle mile travelled clearly signals that improvements in safety must not limit car use.Because children's mobility is not valued the decline in child pedestrian mortality has taken place at its expense.
The Achievement of An Early Complete Cytogenetic Response (CCyR) Is A Major Determinant for Outcome In Patients (pts) with Early Chronic Phase (CP) Chronic Myeloid Leukemia (CML) Treated with Tyrosine Kinase Inhibitors (TKIs).
Authors: Elias Jabbour, Hagop M. Kantarjian, Jenny Shan, Susan O'Brien, MD, Tapan Kadia, Gautam Borthakur, Alfonso Quintas-Cardama, Guillermo Garcia-Manero, Farhad Ravandi, Jorge Cortes
Journal: Blood (2010)
Dermabrasion
Authors: Saul B. Gilson
Journal: JAMA (1969)

<h3>To the Editor:—</h3> The article inThe Journal(<b>206</b>:607, 1968) dates dermabrasion's origin at 1905. The paramedical literature gives the date of origin of this particular technique when catering to feminine vanity as 1580, in Paris, of course. We read in chapter 14, book 2, of Montaigne's essays, "Who in Paris has not heard of that lady who flayed herself merely to acquire the clearer complexion of a new skin?"
PRESCHOOL EXAMINATIONS BY THE FAMILY DOCTOR
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Wiener Klinische Wochenschrift, Vienna
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Adolescent suicide: second leading death cause
Authors: K. Simmons
Journal: JAMA (1987)

THE RATE OF recorded adolescent suicide has nearly tripled over the last several decades: from 4.5 per 10000015-to 24-year-olds in 1950 to 12.3 in 1980. Suicide is now the second leading cause of death for adolescents and young adults (<i>JAMA</i>1986;256:2060-2061). In 1980, for the first time, the median age of Americans killing themselves was less than 40 years. Since 1980, however, the rate has begun to level off. Some epidemiologists suggest that it will fall into the mid1990s. Although those who study suicide caution against citing any one cause for the rise, they point to possible factors such as the increase in alcohol and substance abuse, change in family structure, decline in church attendance, and uncertainty about the future (including the threat of nuclear war). A recent study, for example, found that the main psychiatric diagnosis for 53% of 133 consecutive young suicides in San Diego was substance abuse
Sexology
Authors: H. I. Lief
Journal: JAMA (1989)

Sexology, indeed the entire field of medicine, has been dominated in the last few years by one disease, acquired immunodeficiency syndrome (AIDS). The impact on our health care provision system is enormous and, as one contemplates the possibility of the breakdown of services, frightening. The fear of acquiring AIDS has also had a significant impact on sexual attitudes and behavior. Homosexual "cruising" (casual sex with strangers) has decreased substantially as homosexuals practice "safer sex." The Multicenter AIDS Cohort Study's investigators report a marked decrease in anal intercourse and other high-risk behaviors and a dramatic decrease in seroconversion rates. In large urban areas, intravenous drug users and their partners are providing more cases of AIDS, so that in many localities half or more of the new cases come from this group. Changes in dating patterns among single heterosexuals, indicating greater care in the selection of partners, although not yet extensively studied,
National concern about drug abuse brings athletes under unusual scrutiny
Authors: V. Cowart
Journal: JAMA (1986)

WHEN UNIVERSITY of Maryland basketball star Len Bias began celebrating his selection as a member of the Boston Celtics professional basketball team on June 17—an ultimate celebration that would end with his death, attributed to cocaine intoxication, early on June 19—there were at least four reports of heart damage or death due to cocaine use in the medical literature of the previous six months (<i>Arch Pathol Lab Med</i>1986;110:479-484,<i>Am J Cardiol</i>1986;57:1185-1186 and 57:496,<i>Am Heart J</i>1986;111:793). The sympathomimetic and vasoconstrictive effects of cocaine may induce tachycardia, hypertension, or coronary artery spasm in some users, resulting in myocardial infarction, arrhythmias, or even sudden cardiac death. In addition, a few people are hypersensitive to even small amounts of cocaine because of a congenital deficiency in the ability of the blood and liver esterases to metabolize the drug. As little as 20 mg can be fatal, although the lethal dose