tbuckley/cabot-search huggingface dataset:
Hypochondriasis and somatization
Authors: R. Kellner
Journal: JAMA (1987)

Between 60% and 80% of healthy individuals experience somatic symptoms in any one week. About 10% to 20% of a random sample of people worry intermittently about illness. A substantial proportion of patients present physicians with somatic complaints for which no organic cause can be found. Patients who are hypochondriacal do not understand the benign nature of functional somatic symptoms and interpret these as evidence of disease. Hypochondriacal concerns range from common short-lived worries to persistent and distressing fears or convictions of having a disease. Hypochondriasis can be secondary to other psychiatric disorders (eg, melancholia or panic disorder), and hypochondriacal attitudes remit when the primary disorder is successfully treated. Patients with primary hypochondriasis are also anxious or depressed, but the fear of disease, or the false belief of having a disease, persists and is the most important feature of their psychopathology. There are substantial differences among hypochondriacal patients in their personalities and psychopathologies. Psychotherapy as well as psychotropic drugs are effective in the treatment of functional somatic symptoms. There are no adequate controlled studies on the value of psychotherapy in hypochondriasis; the recommended guidelines are based on uncontrolled studies of hypochondriasis and on controlled studies of the psychotherapy in similar disorders. The prognosis of functional somatic symptoms as well as that of hypochondriasis is good in a substantial proportion of patients. (<i>JAMA</i>1987;258:2718-2722)
P1.03-07 A Comparison of Consistency of Detecting HER2 Gene Mutations in Peripheral Blood and Tumor Tissue of Non-Small-Cell Lung Cancer Patients
Authors: C. Xu, W. Wang, Q. Zhang, Y. Zhu, W. Zhuang, Y. Huang, Y. Chen, G. Chen, T. Lv, Y. Song
Journal: Journal of Thoracic Oncology (2018)
Severe metabolic complications in a cross-country runner with sickle cell trait
Authors: K. J. Helzlsouer
Journal: JAMA (1983)

A 17-year-old black male with sickle cell trait collapsed after completion of a 5,000-m cross-country race. He manifested CNS dysfunction, disseminated intravascular coagulation, rhabdomyolysis, renal insufficiency, and deep venous thrombosis. Sickle cell crisis may have been etiologic in the pathogenesis of this constellation of abnormalities. (<i>JAMA</i>1983;249:777-779)
Commentaire de travail de Brangewitz M et al., pp. 433
Journal: Endoscopy (2013)

See also: Endoscopic closure of esophageal intrathoracic leaks: stent versus endoscopic vacuum-assisted closure, a retrospective analysisEndoscopy 2013; 45(06): 433-438DOI: 10.1055/s-0032-1326435
The Present Position of Aseptic Surgery: An Erratum
Authors: Sett 7l, L District, Nwntwich Unif, H Chbrles, M L', Wia Xtn, A Balfour, ' Glasg, West Asyum, Wakefield Roberts, W Trothwell, Work- Ht Use, Manchester Taylor, D Grahan, N Telford, Manchester Ohbldren', Arthur Tovey, Generallying-In Hospital, A Whitebouse, L Eng, Middleton Wildish, Steven-Connol Andrew, L Odin, Ch Glasg, Dr Clark, Neilson Georgr, Adams Patr, ; Prisgle, D John, Mclenran Fulton, Martin Anna, Kelly Hutton
Journal: BMJ (1904)
"A PLETHORA OF PHYSICIANS"
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
For 23 g, Read 26 g
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Commentary
Authors: Hugh Seward
Journal: British Journal of Sports Medicine (2001)

To evaluate the sensitivity and specificity of the direct specimen test with monoclonal antibody conjugated with fluorescein isothiocyanate (FITC), cervical smears from 700 Viennese prostitutes were investigated by immunofluorescence microscopy and compared with the results of cultures for Chlamydia trachomatis in McCoy cells. Inclusion bodies in cell culture and elementary bodies on the smear slide were counted and evaluated in four categories. Cultures were obtained from 12.6% (88) of all women investigated, whereas the direct specimen test gave positive results in 10.4% (73). The results indicate that in asymptomatic people with only few inclusion bodies and latent infections, culture on McCoy cells is the more adequate method of identifying Chlamydia trachomatis.
Relentless Shock
Authors: Charles H. Pitegoff
Journal: JAMA (1961)

<h3>To the Editor:—</h3> I read with interest the report inThe Journalof Nov. 5, 1960, on Relentless Shock by Backer and associates. The description of muscular twitching and tremors in both patients, with marked disorientation in one of the patients, suggests strongly the possibility that a condition of magnesium deficency may have existed. I have just seen a similar patient with shock, paroxysmal fibrillation, and marked disorientation, 3 days after a subtotal gastrectomy. Pressor agents were required continuously to maintain the blood pressure. Magnesium therapy was instituted, and within 16 hours the patient could sustain his blood pressure without the need of vasopressor substances. I realize that the situation of the patient I treated was of much shorter duration, and therapy was empirical because magnesium levels were unobtainable. I do think that any occurrence of prolonged shock, twitching, and acute disorientation which cannot be explained by the usual
Abstract 9576: Predictors of Silent Cerebral Events Detected on Magnetic Resonance Imaging in Patients After Atrial Fibrillation Ablation
Authors: Thomas Deneke, Karin Nentwich, Patrick Müller, Markus Roos, Joachim Krug, Andreas Mügge, Atilla Szöllösi, Rainer Schmitt, Anja Schade
Journal: Circulation (2014)

Introduction: Silent cerebral events (SCE) have been identified on magnetic resonance imaging (MRI) in asymptomatic patients after atrial fibrillation (AF) ablation. Silent cerebral lesions represent irreversible cerebral damage, comparative analysis using a consistent MRI definition is missing and factors influencing the risk of SCE are poorly understood. Methods: 351 Patients undergoing AF ablation underwent post-ablation cerebral MRI. SCE were identified based on a sensitive definition using a 1.5Tesla MRI including DWI and ADC-map (but not including FLAIR). AF ablation was performed either using irrigated single-tip radiofrequency (RF) ablation (group 1, N=73), phased RF pulmonary vein isolation (PVI) (group 2, N=129), endoscopically-guided laser balloon (group 3, N=41), cryo-balloon PVI (group4, N=34) and irrigated RF multipolar catheters (nMARQ) (group 5, N=73). Differences in regard to SCE rates were analyzed. Results: In group 1 22%, in group 2 37%, in group 41%, in group 4 21% and in group 5 27% of patients had documented SCE. There was a significantly higher incidence of SCL in patients with compared to without exchanges of catheters over a single transseptal sheath (34% vs. 18%, p=0.007) and in patients with left atrial dilation (48% vs. 30%, p=0.01). In a subgroup analysis incidence of SCE was lower when patients were ablated under continued oral anticoagulation (11%) compared to novel oral anticoagulants (33%) or without continuous appropriate anticoagulation bridged with low-molecular weight heparin (45%). Documented left atrial low-voltage areas were associated with a higher incidence of SCE (46% versus 24% in the control group). Conclusions: When using a sensitive MRI definition of SCE incidences are relevantly higher compared to using the “old” definition including the FLAIR-sequence. Technology-associated and procedural characteristics associated with a higher risk of SCE have been identified. Modification of procedural steps of the AF ablation procedure may further reduce the risk of SCE.
Results from the CADMUS Jr study: ustekinumab for treating plaque psoriasis in children
Journal: British Journal of Dermatology (2020)

Psoriasis is a common disease, affecting 2-3% of people worldwide.It causes scaly red plaques on the skin and is associated with other diseases like obesity and diabetes.Psoriasis is triggered by overactivity of molecules in the immune system.Ustekinumab is a type of medicine called a biologic drug that improves psoriasis by blocking two immune system molecules (interleukin-12 and interleukin-23; IL-12/23).It is approved for use in patients who are aged 12 years or over.In the CADMUS Jr study, we tested if ustekinumab was effective in 44 children aged 6-12 years with psoriasis in Europe, Canada and the U.S.A. Patients received doses of ustekinumab, based on their weight, at weeks 0 and 4 and then every 12 weeks for a year.We evaluated efficacy, assessed improvement in quality of life (QoL), and observed safety outcomes.Over three-quarters of patients (77.3%) had clear skin or just minimal psoriasis remaining by week 12 and maintained that improvement through week 52.In over one third of patients at week 12 and more than half at week 52, psoriasis had completely cleared.Among patients reporting that psoriasis affected their QoL before starting treatment, most said the disease no longer had an effect at weeks 12 and 52.No unexpected adverse effects (unwanted side effects) were reported, showing that ustekinumab was well tolerated in these young patients.In summary, we found that ustekinumab improved psoriasis and QoL and was safe to use in children (6-12 years old) through one year of treatment in our CADMUS Jr study.These results were similar to those reported for over 100 adolescents (12-18 years old) treated with ustekinumab (CADMUS study).
Phase II trial of the irreversible oral pan-human EGF receptor (HER) inhibitor PF-00299804 (PF) as first-line treatment in recurrent and/or metastatic (RM) squamous cell carcinoma of the head and neck (SCCHN).
Authors: L. L. Siu, S. J. Hotte, S. A. Laurie, S. Singh, E. Winquist, S. K. L. Chia, E. X. Chen, K. K. Chan, T. Wang, I. Taylor, A. Ruiz-Garcia, C. Mormont, D. Soulieres
Journal: Journal of Clinical Oncology (2011)

5561 Background: PF is a potent, irreversible small molecule pan-HER tyrosine kinase inhibitor (TKI) with pre-clinical antitumor activity against EGFRvIII-mutated cell lines and xenograft models resistant to reversible EGFR TKIs. Methods: Eligible patients (pts) had untreated RM SCCHN with measurable disease and no prior anti-EGFR therapy. Paired biopsies as feasible were done for biomarkers; plasma was collected for PK. PF is administered at 45 mg p.o. every day in 21-day cycles. Primary endpoint is objective response rate (ORR), assessed every 6 weeks by RECIST 1.1. A Simon 2-stage trial design with H0: ORR ≤ 5% and Ha: ORR ≥ 15% stipulated that ≥ 2 responses must be observed in first 23 evaluable pts to proceed to stage II, ≥ 6 responses in first 56 evaluable pts to meet primary objective. Results: 69 pts are enrolled: median age 62 years (range: 40-82); M:F (%)= 88:12; ECOG 0:1:2 (%) = 30:64:6; prior radiation = 93%; prior chemotherapy = 46%; ex-smoker/current smoker = 86%. In 68 pts evaluable for toxicity, treatment-related adverse events (TRAEs) led to drug discontinuation in 7 (10%), dose reduction in 19 (28%) and interruption in 26 (38%). The most frequent grade 1 and 2 TRAEs were (% of pts): diarrhea (71%), dermatitis acneiform (63%), dry skin (44%), stomatitis (32%), fatigue (31%), pruritis (28%) and hand-foot reaction (26%). Gr 3 TRAEs > 3% included: diarrhea (13%), fatigue (9%), dermatitis acneiform (7%) and hand-foot reaction (4%). Among the first 56 evaluable pts, 6 pts (11%) achieved a partial response (median duration = 4.3 months); 35 pts (63%) had stable disease, of which 6 pts (11%) maintained disease stabilization ≥ 24 weeks. Data for all 69 pts at time of submission: median PFS = 2.8 months (95% C.I. 2.6-4.1 months), 6-month PFS =15% (95% C.I. 5-29%), and median survival = 7.6 months (95% C.I. 6.4-12 months). PK and biomarker analyses will be presented. Conclusions: Primary endpoint was met and toxicity profile was manageable. Antitumor activity of PF is consistent with EGFR TKIs, with ongoing molecular characterization of EGFRvIII mutations to evaluate potential as a biomarker of clinical activity.
Home Births and Minimal Medical Interventions
Authors: Pieter E. Treffers
Journal: JAMA (1990)

The Dutch system of obstetric care is attracting increasing attention from various parts of the world because of the large number of home births and the relatively low rate of medical intervention. The opinion prevalent among professionals and the general public is that pregnancy and labor are fundamentally normal events that only require medical intervention if there is a valid reason. Until recently, the small scale of the independent practices of midwives, general practitioners, and obstetricians providing medical and obstetric care in the country hampered the collection of reliable scientific information. The development of a national obstetric database is in an advanced stage, but up to now only limited statistical data are provided by the Central Bureau of Statistics and the Maternity Home Help Organization. New information recently became available from several research projects, providing more insight into the effectiveness of the system. <h3>GENERAL INFORMATION</h3> After 1945 the percentage of
Abstract 4939: Alteration of TGFB signaling pathway predicts worse prognosis in pancreatic ductal adenocarcinoma
Authors: Mao Li, Ang Li, Xiaochen Zhao, Shengzhong Hou, Shan Lu, Yu Mou, Xubao Liu, Dan Cao, Shangli Cai, Bole Tian
Journal: Cancer Research (2019)

Abstract Background: For pancreatic ductal adenocarcinoma (PDAC), a reliable and practical prognostic biomarker is still in unmet needs. Transforming growth factor beta (TGFB) signaling pathway is one of the core pathways involved in tumor initiation and progression via canonical and non-canonical pathway. The prognostic value of TGFB pathway genes as a functionally related group in PDAC is rarely studied.Methods: 72 PDAC patients who underwent surgery between November 30, 2015 and September 13, 2017 in West China Hospital, Sichuan University were identified and included in this study. Whole-exome sequencing (WES) or targeted next-generation sequencing was performed with tumor tissue from primary tumors. Clinical data was retrospectively collected. Clinicopathologic characteristics and overall survival were analyzed.Results: Genetic alterations were detected in 70 patients (97.2%). While 1 patient (1.4%) had only one genetic alteration, 28 patients (38.9%) had 2-4 genetic alterations and 43 patients (59.7%) had ≥5 genetic alterations. Overall, 25 patients (34.7%) with alteration of TGFB pathway and 47 patients (65.3%) with wild type of TGFB pathway were identified as TGFBm+ group and TGFBm- group respectively. TGFBm+ group had worse overall survival (HR, 1.875, 95% CI: 1.06-4.72; P = 0.04), especially in patients who had radical surgery (HR, 3.11, 95% CI: 1.11-20.3; P = 0.04). While in the subgroup of patients who underwent palliative surgery, OS was not statistically different (HR, 0.93, 95% CI: 0.42-2.04; P = 0.85). Subgroup analysis showed that overall survival hazard ratio favored participants with wild type of TGFB pathway in patients with ECOG performance score &amp;gt;1, abnormal CA199, without metastasis, stage I to II and patients who accepted radical surgery.Conclusion: Alteration of TGFB pathway genes is prevalent in PDAC. Inferior prognosis was observed in PDACs with mutations of TGFB pathway. TGFB signaling might play different role in different tumor stages, which is consistent with previous report about paradoxical effect of TGFB pathway. Genomic sequencing could help screen out patients at risk after surgery and adjuvant therapy might benefit this subgroup of PDACs. Note: This abstract was not presented at the meeting. Citation Format: Mao Li, Ang Li, Xiaochen Zhao, Shengzhong Hou, Shan Lu, Yu Mou, Xubao Liu, Dan Cao, Shangli Cai, Bole Tian. Alteration of TGFB signaling pathway predicts worse prognosis in pancreatic ductal adenocarcinoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4939.
Ruptured stomach after Heimlich maneuver
Authors: R. E. Visintine
Journal: JAMA (1975)

APPLYING sharp force to the abdomen just below the diaphragm, as described by Heimlich,<sup>1</sup>has been widely published as a life-saving measure. A considerable number of lives,<sup>2</sup>including that of the patient in this report, have undoubtedly been saved by persons who have read about this technique. The forceful, sudden pressure applied by the quick upward push on the epigastrium can often expel the life-threatening plug of food. To date, no serious complications resulting from this maneuver have been reported. According to Heimlich (personal communication), fractured ribs seem to have been the only significant problem, and they have been rare. The case we are reporting involved a far more serious complication. <h3>Report of a Case</h3> A 74-year-old man was attending a club banquet, when he suddenly appeared to be choking and lost consciousness. An alert companion used the Heimlich maneuver, and a large piece of meat was expelled.
Influence of DAA treatment in patients with HCV-cirrhosis and esophageal varices on liver transplant free survival and risk of developing hepatocellular carcinoma
Authors: Noelia Rodríguez Ferreiro, Pablo Florez Diéz, Alejandro Nieto Jara, Victor J Beltrán, Miguel Fraile, Carmen Álvarez-Navascués, Maria Luisa Gonzalez Dieguez, Maria Varela, Valle Cadahiá-Rodrigo, Manuel Rodríguez
Journal: Journal of Hepatology (2020)
What's new in the other general journals
Authors: Kristina Fister
Journal: BMJ (2006)

Harm reduction programmes have been criticised for giving a false impression to adolescents that heroin use doesn't have to be associated with as much harm to the individual as is traditionally thought. Switzerland has had a liberal policy towards harm reduction. And a recent study shows that the incidence of heroin misuse has been falling under an extensive harm reduction programme, which includes methadone substitution with low threshold of illicit use. Credit: LANCET The researchers analysed an anonymised treatment register of almost 80% of the heroin addicts treated between 1991 and March 2005 in the canton of Zurich, which included more than 7000 people. Using the conditional lag time distribution, they estimated the proportion of addicts not yet in substitution treatment programmes and modelled the overall prevalence of heroin misuse as a function of incidence and cessation rate. Credit: ANN INT MED After its all time peak in 1990, the incidence of regular heroin use declined fourfold in the next decade, more than in any other country with data permitting such analysis. The data showed a decline, by 4% a year, in the population of problematic heroin addicts, defined as people who sought and entered treatment. However, the rates of cessation (leaving the substitution programme and not re-entering within a decade) in Switzerland are among the lowest recorded. Lancet 2006;367: 1830–4 [OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] Children who had ventricular fibrillation or tachycardia before the onset of cardiac arrest have better prognosis than children in cardiac arrest who develop ventricular fibrillation or tachycardia during cardiopulmonary resuscitation. This finding is from a multicentre register study of more than 1000 consecutive children with cardiac arrest. It contradicts previous evidence, which was based on studies from single institutions with small sample sizes, and the traditional view that ventricular fibrillation and tachycardia are “good” cardiac arrest rhythms. Children who develop ventricular fibrillation … [1]: {openurl}?query=rft.jtitle%253DLancet%26rft.stitle%253DLancet%26rft.aulast%253DNordt%26rft.auinit1%253DC.%26rft.volume%253D367%26rft.issue%253D9525%26rft.spage%253D1830%26rft.epage%253D1834%26rft.atitle%253DIncidence%2Bof%2Bheroin%2Buse%2Bin%2BZurich%252C%2BSwitzerland%253A%2Ba%2Btreatment%2Bcase%2Bregister%2Banalysis.%26rft_id%253Dinfo%253Adoi%252F10.1016%252FS0140-6736%252806%252968804-1%26rft_id%253Dinfo%253Apmid%252F16753485%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1016/S0140-6736(06)68804-1&link_type=DOI [3]: /lookup/external-ref?access_num=16753485&link_type=MED&atom=%2Fbmj%2F332%2F7554%2F1383.atom [4]: /lookup/external-ref?access_num=000238194200028&link_type=ISI
Cage Allocation Designs for Rodent Carcinogenicity Experiments
Authors: Agnes M. Herzberg, Stephen W. Lagakos
Journal: Environmental Health Perspectives (1991)

Cage allocation designs for rodent carcinogenicity experiments are discussed and presented with the goal of avoiding dosage group biases related to cage location. Considerations in selecting a cage design are first discussed in general terms. Specific designs are presented for use in experiments involving three, four, and five dose groups and with one, four, and five rodents per cage. Priorities for balancing treatment groups include horizontal position on shelf and shelf of rack, nearest neighbor balance, and male–female balance. It is proposed that these balance criteria be considered together with practical issues, such as the ability to accurately conform to a design and to determine a sensible and efficient design for each experiment.
Book Review Handbook of Anaesthetics . (Formerly by Ross and Fairlie.) Revised by R. J. Minnitt, M.D. (Liverpool), D.A. (D.C.P. &amp; S. Eng.). With chapters on local and spinal anesthesia by W. Quarry Wood, M.D., Ch.M., F.R.C.S.E. Fifth edition. 12°, cloth, 364 pp., with 103 illustrations. Baltimore: Williams and Wilkins Company, 1940. $4.00.
Journal: New England Journal of Medicine (1941)