tbuckley/cabot-search huggingface dataset:
Abstract 2123: Gadolinium-DTPA-Exposure-Induced Systemic Inflammatory Response (GEISIR) in Patients with Chronic Renal Insufficiency
Authors: Henning Steen, Evangelos Giannitsis, Martin Zeier, Vecat Schwenger, Hugo A Katus
Journal: Circulation (2007)

Background Cardiovascular morbidity is extraordinarily high in patients with chronic kidney disease (CKD) and accurate cardiovascular assessment is necessary. Due to the renal toxicity of certain contrast agents, this assessment has often been avoided. MRI contrast agents, such as gadolinium-DTPA, were originally thought to be a non-nephrotoxic alternative to iodinated contrast agents. The purpose of this study was to evaluate the safety of gadolinium-DTPA and to assess side effects in CKD patients who received gadolinium-DTPA during cardiovascular MRI. Methods Between August 2004 and December 2006, we longitudinally investigated 76 end-stage renal disease (ESRD) patients (70 haemodialysis=HD, 6 peritoneal dialysis=PD) who received gadolinium-DTPA during cardiovascular MRI. Results We report for the first time that 8% of ESRD patients experienced a gadolinium-DTPA-exposure-induced systemic inflammatory response (GEISIR). Furthermore, two of them previously not dialyzed CKD patients - rapidly progressed to end-stage renal failure. Conclusion Exposure to gadolinium-DTPA is not as harmless as was initially assumed. In ESRD patients, gadolinium-DTPA may induce severe adverse events, such as GEISIR. Therefore, short-term re-administration of gadolinium should be avoided in ESRD patients. Due to the extremely long half-life of gadolinium-DPTA, especially in PD patients, careful consideration should be given as to whether or not gadolinium-exposed patients require hemodialysis. Further data are imperative to determine optimal measures after gadolinium exposure in CKD patients
449PD Relative abundance of EGFR mutations predict tumor metastasis and EGFR-TKIs prognosis in patients with non-small cell lung cancer
Authors: H. Zhen, Q. Wang, H. Wang, H. Tang, Z. Zhang, Y. Wu, L. Wang, D. Zhao, L. Yang, B. Wei, J. Ma, Y. Guo
Journal: Annals of Oncology (2016)
Highlights
Journal: JAMA (2016)

The value of integrated team-based delivery models-incorporating physical and mental health care in a primary care setting-is not established.Reiss-Brennan and colleagues evaluated the association of integrated team-based care with measures of health care quality, utilization, and cost in a retrospective cohort of 113 452 patients enrolled in 102 primary care practices of an integrated health care system.The authors found that compared with traditional care model practices, receipt of care in integrated team-based care practices was associated with higher rates of some measures of care quality, lower rates for some measures of acute care utilization, and lower actual payments received by the health delivery system.In an Editorial, Schwenk discusses resource utilization and costs of integrated behavioral and primary care health systems.Editorial 822 CME jamanetworkcme.com Discriminating Bacterial vs Viral Infection in Febrile Children 835Clinical features do not reliably distinguish bacterial from viral infection, so many children receive unnecessary antibiotic treatment while awaiting culture results.In an analysis of data from 370 febrile children who presented to the hospital, Herberg and colleagues assessed whether bacterial infection could be distinguished from viral infection using whole-blood gene expression profi ling.The authors report identifi cation of a 2-transcript host RNA signature that discriminated bacterial from viral infection.In an Editorial, Bauchner discusses the potential of genetics in the evaluation of febrile children.
A case of severe hepatolithiasis after hepaticojejunostomy with Roux-en-Y reconstruction treated by endoscopic ultrasound-guided transhepatic antegrade stone removal
Authors: Toshihiro Homma, Kenjiro Yamamoto, Takayoshi Tsuchiya, Ryosuke Tonozuka, Hirohito Minami, Eri Joyama, Takao Itoi
Journal: Endoscopy (2020)

Corrected by: Correction: A case of severe hepatolithiasis after hepaticojejunostomy with Roux-en-Y reconstruction treated by endoscopic ultrasound-guided transhepatic antegrade stone removalEndoscopy 2021; 53(06): C7-C7DOI: 10.1055/a-1272-9368
Abstract 46: Effect Of Infliximab And Plasma Exchange Therapy On Activated Monocytes/macrophages In Kawasaki Disease Intractable To IVIG.
Authors: Keiichi Koizumi, Nobuyuki Katsumata, Takako Toda, Hiroaki Kise, Yohei Hasebe, Kanji Sugita, Minako Hosiai
Journal: Circulation (2015)

Background: Kawasaki disease (KD) is a generalized vasculitis of unknown etiology that occurs predominantly in infant and children. KD has been reported as one of the cytokine-induced disease. The monocyte / macrophage is thought to the subject of proinflammatory cytokines sources. It has been reported that IVIG therapy in KD normalizes the increased numbers of activated CD14 + CD16 + monocyte / macrophage. We examined the effect of the infliximab (IFX) and plasma exchange (PE) therapy on the peripheral blood cells, especially the monocyte / macrophage in KD intractable to intravenous immunoglobulin (IVIG). Patients: We studied 9 patients with KD intractable to IVIG (2g/kg/dose), seven with IFX therapy (5mg/kg/dose), four with PE therapy (including two patients of refractory to IFX therapy), who were seen at our hospital. The median age and body weight were 3.3 years (range, 0.5 to 5.5 years) and 13.0kg (range, 6.1 to 20.3kg), respectively. White blood cell count and differentiation were compared before with after the treatment. Results: IFX group: White blood cell count was significantly decreased to 11640 ± 3509 from 14141 ± 4673/μl. The neutrophil count was decreased and the lymphocyte count was increased. Both the counts were normalized. CD14 + monocyte / macrophage count (normal value: 339 ± 91/μl) was significantly decreased to 488 ± 195 from 999 ± 528/μl. Especially, the activated CD14 + CD16 + monocyte / macrophage count (normal value: 35 ± 18/μl) was significantly decreased to 69 ± 45 from 176 ± 164/μl. PE group: White blood cell count was decreased to 10683 ± 4665 from 16810 ± 2527/μl. Neutrophil count was decreased, but the lymphocyte count was no changed. CD14 + monocytes / macrophage count was decreased to 401 ± 278 from 1402 ± 1286/μl. The activated CD14 + CD16 + monocyte / macrophage count was decreased to 24 ± 9 from 243 ± 364/μl. Conclusion: In KD intractable to IVIG, the CD14 + CD16 + monocyte / macrophage count of prior to the treatment was increased. Both IFX and PE therapy has the effects of decreasing the CD14 + CD16 + monocyte / macrophage count which involved in the pathogenesis of KD.
Single fathers: neglected, growing, and important
Authors: None The Lancet Public Health
Journal: The Lancet Public Health (2018)

Families are changing worldwide. Of the world's 2·3 billion children, 320 million (14%) are living in a single-parent household—18% in France, 20% in Canada, 24% in the UK, 27% in the USA, and 43% in South Africa. Single-parent families are becoming increasingly common in many countries, mainly due to rising rates of divorce and couples having children outside of marriage. These trends are set to increase. The OECD report, Doing better for families, projects that by 2025–30 the proportion of sole-parent families is expected to rise in all OECD countries (except Germany), from 8% for Switzerland and the USA to 29% for New Zealand.
Peripheral Arterial Surgery
Authors: R. Clement Darling
Journal: New England Journal of Medicine (1969)

Obliterative Arterial DiseaseLower Extremities Diagnostic measures. Despite the availability of electronic gadgetry and sophisticated angiography, the diagnosis and prognosis of ischemic disease of the lower extremities can generally be made by a carefully taken history and diligent physical examination. Both the location of the occlusive process and the degree of functional impairment should be recorded. A clinical oscillometer serves as a guide in estimating segmental pulse volume, substantiating the absence or presence of pulses and, in many cases, determining the degree of collateral blood flow distal to an occlusive lesion.Angiography, however, is of prime value to assess . . .
Role of the alveolar macrophage in lung injury: studies with ultrafine particles
Authors: G Oberdörster, J Ferin, R Gelein, S C Soderholm, J Finkelstein
Journal: Environmental Health Perspectives (1992)

We conducted a series ofexperiments with ultrfine particles (-20 nm) and larger particles (< 200 nm) of "nuisance" dusts to evaluate the involvement of alveolar macrophages (AM) in particle-induced lung injury and particle transloca- tion in rats.After intratracheal instillation of both ultrafine particles and larger particles ofTO2, we found a highly in- creased interstitial access of the ultrafine particles combined with a large acute infmmatory reaction as determined by lung lavage parameters.An additional experiment revealed that intratracheal nstillation of ph ctized ultrfine 1102 particles (inside AM) prvented both the puhonary inflam ry reaction and the interl access ofthe utrafin particles.Another experiment showed that the influx of polymorphonuclear cells (PMN) into the alveolar space unexpectedly decreased with higher doses ofultrafine particles, wheras alveolar epithelial permeability (protein leakage) increased.The divergence between PMN influx into the alveolar space and changes in alveolar epithelal permeability implies that they are separate events.Pulmonary inflammatory parameters determined by lung lavage analysis correlated best with the surface area ofthe retained particles rather than with their mass, volume, or numbers.Because higher doses resulted in an increased interstitialized fraction of particles, we suggest that inflamatory events induced by particles in the in- terstitial space can modify the inflammation in the alveolar space detectable by lung lavage.Our results demonstrate the dual role of AM for modifying particle-induced lung injury, i.e., both preventing such injury and contributing to it.We-& conclude that the increased pulmonary toxicity ofultrafine particles is related to their larger surface areaand to their in- creased interstitial access.Further, we suggest that the inte stizaon ofparticles isimportant for inducion ofpulmonary fibrotic reactions and that ultrafine particles of nuisance dusts should have different threshold limit values for occupa- tional exposure because of their increased puhnonary toxicity.
Overactivation of STAT Pathways and Overexpression of Survivin Confer Resistance to FLT3 Inhibitors and Could Be Therapeutic Targets in AML.
Authors: Jianbiao Zhou, Chonglei Bi, Lai Fong Poon, Viraj J. Janakakumara, Jiaying Khng, Hanry Yu, Keith B. Glaser, Daniel H. Albert, Davidsen K. Davidsen, Chien-Shing Chen
Journal: Blood (2007)
Self-reported Asthma is Associated with Increased Risk of Hospitalization and/or Death Due to Coronary Heart Disease among Never Smoking Men and Women.
Authors: Carlos Iribarren, Mark D Eisner, Alan S Go, Stephen Sidney, Arthur L Klatsky
Journal: Circulation (2001)

P61 Inflammation is thought to play a crucial role in the pathogenesis of coronary atherosclerosis. Asthma is a chronic inflammatory disease and a major cause of pulmonary morbidity and mortality. However, very few prospective studies exist evaluating the question of whether asthma is related to increased risk of cardiovascular diseases, and none were restricted to never smokers. We examined the prospective association between self-reported asthma diagnosis and risk of hospitalization and/or death due to coronary heart disease (CHD, ICD-9 codes 410-414) in a large population-based sample. Data on self-reported health conditions, including asthma, and cardiovascular risk factors were collected at a health maintenance organization (HMO) in the San Francisco Bay Area between 1979 and 1985. The sample included 14,047 never smoking women and 7,989 never smoking men aged 35-89 years (mean ± SD, 50.4 ± 11.9 years), 56% Caucasian, who were free of known CHD at baseline. Of those, 652 women (4.6%) and 410 men (5.1%) self-reported physician-diagnosed asthma. Follow-up for hospitalization and/or death was available through the end of 1998 (median=13.4 years). Using Cox proportional hazards regression, we censored persons leaving the health plan at their last known date of HMO membership. Compared to subjects with no-known history of asthma, and after adjustment for age, sex, race, education level, alcohol consumption, body mass index, serum cholesterol, systolic blood pressure and diabetes, self-reported asthma was significantly associated with higher risk of hospitalization and /or death due to CHD (RR=1.33; 95% CI=1.05-1.67; p=0.02). Also in multivariate analysis, asthma under treatment at the time of the baseline examination was more strongly associated with CHD risk (RR=1.82; 95% CI=1.23-2.69; p=0.003). No interactions were found between self-reported asthma or asthma under treatment and patient sex. We conclude that, in a large representative population-based sample of non-smokers, self-reported asthma was associated with increased risk of coronary heart disease.
Patterns of drug use among marihuana smokers
Authors: A. S. Carlin
Journal: JAMA (1971)

One hundred and six male marihuana smokers were interviewed concerning their use of other drugs. Seventy-four percent admitted experimentation with psychedelic drugs and 6% experimented with heroin. Compared to earlier findings, use of psychedelic drugs seems to be growing, while use of heroin remains about the same.
Recurrent pulmonary infarction in adult chickenpox pneumonia
Authors: N. Glick
Journal: JAMA (1972)

The diagnosis of repeated pulmonary emboli was made for a 32-year-old man with chickenpox pneumonia. This case and previously reported cases emphasize that upon recognition, the treatment of pulmonary emboli occurring with chickenpox pneumonia may be the only specific therapy which can be offered to these often critically ill patients.
Neutral Antibodies to the TSH Receptor Are Present in Graves’ Disease and Regulate Selective Signaling Cascades
Authors: Syed A. Morshed, Takao Ando, Rauf Latif, Terry F. Davies
Journal: Endocrine Reviews (2010)

TSH receptor (TSHR) antibodies (Abs) may be stimulating, blocking, or neutral in their functional influences and are found in patients with autoimmune thyroid disease, especially Graves’ disease (GD). Stimulators are known to activate the thyroid epithelial cells via both Gs- and Gq-coupled signaling pathways, whereas blockers inhibit the action of TSH and may act as weak agonists. However, TSHR neutral Abs do not block TSH binding and are unable to induce cAMP via Gsα. The importance of such neutral Abs in GD remains unclear because their functional consequence has been assumed to be zero. We hypothesized that: 1) neutral TSHR Abs are more common to GD than generally recognized; 2) they may induce distinct signaling imprints at the TSHR not seen with TSH itself; and 3) these signaling events may alter cellular function. To evaluate these hypotheses, we first confirmed the presence of neutral TSHR Abs in sera from patients with GD and then, using mouse and hamster neutral monoclonal TSHR Abs (N-mAbs) performed detailed signaling studies, including a proteomic Ab array, with rat thyrocytes (FRTL-5) as targets. This allowed us to examine a battery of signaling cascades and their downstream effectors. Neutral TSHR Abs were indeed frequently present in sera from patients with GD. Sixteen of 27 patients (59%) had detectable neutral TSHR Abs by competition assay with N-mAbs. On examining signaling cascades, we found that N-mAbs induced signal transduction, primarily via the protein kinase A II cascade. In addition to the activation of phosphatidylinositol 3/Akt, N-mAbs, unlike TSH, had the ability to exclusively activate the mammalian target of rapamycin/S6K, nuclear factor-κB, and MAPK-ERK1/2/p38α signaling cascades and their downstream effectors ribosomal kinase/Mnk1/mitogen/stress-activated kinase-1 and N-mAbs activated all forms of protein kinase C isozymes. To define the downstream effector mechanisms produced by these signaling cascades, cytokine production, proliferation, and apoptosis in thyrocytes were investigated. Although N-mAbs produced less cytokines and proliferation compared with TSH, they had the distinction of inducing thyroid cell apoptosis under the experimental conditions used. When dissecting out possible mechanisms of apoptosis, we found that activation of multiple oxidative stress markers was the primary mechanism orchestrating the death signals. Therefore, using oxidative stress-induced apoptosis, N-mAbs may be capable of exacerbating the autoimmune response in GD via apoptotic cells inducing antigen-driven mechanisms. This may help explain the inflammatory nature of this common disorder.
Normal Th1 development following long-term therapeutic blockade of CD154-CD40 in experimental autoimmune encephalomyelitis
Authors: Laurence M. Howard, Serge Ostrovidov, Cassandra E. Smith, Mauro C. Dal Canto, Stephen D. Miller
Journal: Journal of Clinical Investigation (2002)

Experimental autoimmune encephalomyelitis (EAE) is a Th1-mediated demyelinating disease of the CNS with similarities to multiple sclerosis. We and others have shown that a short-term course of anti-CD154 mAb treatment to block CD154-CD40 interactions can be used to prevent or even treat ongoing PLP139-151–induced relapsing EAE. However, little is known of the long-term effects of CD154 blockade on the development of antigen-specific T cell function. Here, we show that short-term treatment with anti-CD154 at the time of PLP139-151/CFA immunization inhibits clinical disease for up to 100 days after immunization. At this point, comparable numbers of Th1 cells are observed in anti-CD154 and control Ig–treated mice, as assessed by antigen-specific ELISPOT assays. Thus, the long-term Th1/Th2 balance is largely unaffected. Inflammatory responses are diminished in anti-CD154–treated mice, as indicated by reduced in vivo delayed-type hypersensitivity and reduced levels of splenic IFN-γ secretion in vitro. However, upon adoptive transfer of T cells isolated from the spleens of anti-CD154–treated mice, these cells contributed as effectively to clinical disease as those obtained from control-treated mice. Thus, anti-CD154 therapy leads to long-term therapeutic efficacy without exerting a long-term influence on Th1 development.
A pro-inflammatory variant in the TLR5 gene is associated with hepatocellular carcinoma in patients with cirrhosis due to steatohepatitis.
Authors: Hans Dieter Nischalke, Janett Fischer, Benjamin Krämer, Bettina Langhans, Felix Stickel, Jacob Nattermann, Ulrich Spengler, Thomas Berg, Christian Strassburg, Philipp Lutz
Journal: Journal of Hepatology (2020)
Dislocation of the elbow with brachial artery injury
Authors: O. E. Aufranc
Journal: JAMA (1966)

Dr. Turner: A 50-year-old printer caught his ring in a printing machine, and his entire left arm was drawn into the machine. The arm was crushed at the elbow under a heavy metal printing stamp. The limb was withdrawn, and he was taken to a community hospital where the diagnoses of elbow dislocation and brachial artery laceration were confirmed. With the patient under general anesthesia, the elbow was reduced and the wound was debrided. The lacerated brachial artery was repaired by primary anastomosis. There was persistent postoperative bleeding from the wound itself, but distal circulation was not restored. The patient was referred to the Massachusetts General Hospital for further evaluation, and arrived here approximately seven hours following his injury. Results of examination on arrival were normal except for the left arm, which was cold, pulseless, cyanotic, and hypesthetic below the elbow. There was complete absence of pulsatile arterial flow in
DIAGNOSTIC METHODS IN WHOOPING COUGH
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PIERRE-CARL POTAIN (1825-1901) CARDIOVASCULAR PHYSICIAN
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Highlights
Journal: JAMA (2018)

Mucus Clearance in Patients Receiving Invasive Ventilation 993Nebulization with mucolytics and bronchodilators facilitates the clearance of airway mucus in patients receiving invasive ventilation, but the procedure causes patient discomfort.Van Meenen and colleagues randomized 922 patients who were receiving invasive ventilation and found that providing nebulization only when clinically warranted was a reasonable alternative to routine nebulization. CME jamanetwork.com/learning CARING FOR THE CRITICALLY ILL PATIENT Referral of Hospitalized Children for Critical Care 1002It can be challenging to identify children at risk of clinical deterioration and refer them promptly for critical care.Parshuram and colleagues for the EPOCH Investigators of the Canadian Clinical Trials Group randomized 21 hospitals to implement the Bedside Paediatric Early Warning System (BedsidePEWS) or maintain usual care and found that Bedside-PEWS did not decrease all-cause mortality among hospitalized pediatric patients.In an Editorial, Halpern suggests that the secondary outcome fi nding of a decrease in signifi cant clinical events on the wards at the BedsidePEWS hospitals implies that clinically necessary interventions were more likely to be performed in the controlled and resource-intensive intensive care unit setting.