tbuckley/cabot-search huggingface dataset:
Topical retinoic acid changes the epidermal cell surface glycosylation pattern towards that of a mucosal epithelium
Authors: C. E. M. GRIFFITHS, E. DABELSTEEN, J. J. VOORHEES
Journal: British Journal of Dermatology (1996)

Topical all-trims retinoic acid (RA) produces a number of epidermal changes which are indistinguishable from those observed following treatment with a local irritant, namely sodium lauryl sulphate (SI. S). This observation has led to criticism that the efficacy of RA in disorders such as photoageing. Is merely a result of irritancy. In stratified epithelia, the cellular differentiation process is characterized by a stepwise synthesis of cell surface carbohydrates, and each type of stratified epithelium has its own specific pattern of carbohydrate expression. Glycosyltransferases, which are responsible for carbohydrate synthesis, are influenced by retinoids. Thus, we investigated whether epidermal cell surface glycosylation is altered in skin treated with topical RA, and contrasted it with changes induced by topical SLS Skin biopsies were obtained from seven normal volunteers who had been treated, on three separate areas of buttock skin, with single applications of 0·1% RA. 2% SLS, or vehicle creams, followed by 4-day occlusion. Biopsies were assessed immunohistologically using highly specific monoclonal antibodies to cell surface carbohydrates (types 1, 2 and 3 chain structures), previously demonstrated in the epidermis and in oral mucosal epithelium. Although type 1 chain structures were not demonstrated in any of the samples, the distribution of type 2 and 3 chain structures in RA-treated epidermis was altered towards that seen in a mucosal epithelium. T antigen, a mucin-type cell surface carbohydrate structure normally expressed throughout the epidermis, was only observed in the granular layer of RA-treated epidermis-a feature of mucosal epithelia. Ley, normally only seen in non-keratinized buccal epithelium, was strongly expressed in RA-treated epidermis. In contrast, the glycosylation pattern of the SLS-treated epidermis was not significantly different from that observed after vehicle treatment. Thus, RA treatment converts normal stratified epithelium towards the phenotype of mucosal epithelium with a decrease in T antigen and a concomitant increase in Ley. These changes the not observed following treatment with SLS and identify an important difference between RA effects and irritancy.
Patient Interviews
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
HHS Secretary Louis Sullivan speaks out for improved health
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
LONDON
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
In vitro fertilization enters stormy adolescence as experts debate the odds
Authors: C. A. Raymond
Journal: JAMA (1988)

A CASINO may have been just the right choice to discuss in vitro fertilization. Like gambling, "test-tube baby" technology is a chancy and expensive proposition, suggested many practitioners interviewed during the 43rd Annual Meeting of the American Fertility Society in Reno, Nev. Ten years after Louise Brown's birth was ballyhooed in banner headlines, nearly 3000 babies owe their births to in vitro fertilization. This has given the procedure a cachet in the public's mind that even some of its advocates think is unwarranted. Others think the technique is or will soon become the infertility treatment of choice. Buffeted by the pressures of commercial interests and near-desperate patients searching for a technological miracle, the technique has become a major player in an increasingly lucrative infertility market. As such, it is at the center of a swirl of controversy. Questions about whether and how the performance of in vitro fertilization clinics should
The Hip
Authors: Ben L. Allen
Journal: JAMA (1966)

Addressed to orthopedic surgeons and research workers, this monograph provides a synthesis of recent research information. Because the author assumes that the reader understands the anatomy and pathology of the hip, the book will be too esoteric for the nonspecialist. To the initiated, however, it will give an accurate view of current investigation and a concept of how many diverse factors may relate to produce hip disease. The author devotes the first portion of his book to the anatomy and physiology of the hip. Little of the information concerning the circulation to the femoral head and the forces acting on the joint in various activities appears in any standard text. In the second portion he discusses the most common afflictions of the hip—congenital dislocation, osteochondritis juvenilis, slipped upper femoral epiphysis, fractures of the neck of the femur, acquired dislocations, tuberculosis and osteoarthritis—and closes with a section concerning rehabilitation of the
Evaluation, diagnosis, and treatment of clinical conditions related to sleep
Authors: A. Kales
Journal: JAMA (1970)

Specific sleep stages are associated with or altered by clinical conditions such as aging, disease states, sleep disorders, and drug use. Gastric acid secretion in patients with duodenal ulcers and nocturnal angina attacks in patients with coronary disease are associated with rapid eye movement (REM) sleep. Sleepwalking and night terrors occur predominantly during stage 4 sleep, while attacks of dyspnea in asthmatic children occur in all stages except stage 4. Enuretic episodes occur predominantly in nonrapid eye movement (NREM) sleep. In treating insomnia, drugs which are effective in the sleep laboratory are recommended. Following the withdrawal of REM suppressant hypnotics, insomnia, increased dreaming, and nightmares may occur and lead to drug dependence. If these drugs are withdrawn, very gradual withdrawal is recommended as well as informing the patient of possible increases in dream frequency and intensity.
Estrogenic and DNA-Damaging Activity of Red No. 3 in Human Breast Cancer Cells
Authors: Craig Dees, Minoo Askari, Scott Garrett, Kellie Gehrs, Don Henley, C. Murray Ardies
Journal: Environmental Health Perspectives (1997)

Exposure to pesticides, dyes, and pollutants that mimic the growth promoting effects of estrogen may cause breast cancer.The pesticide DDT and the food colorant Red No. 3 were found to increase the growth of HTB 133 but not estrogen receptor (ER) negative human breast cells (HTB 125) or rat liver epithelial cells (RLE).Red No. 3, fVestradiol, and DDT increase ER site-specific DNA binding to the estrogen response element in HTB 133 cells and increase cyclin-dependent kinase 2 activity in MCF-7 breast cancer cells.Site-specific DNA binding by p53 in RLE, HTB 125, HTB 133, and MCF-7 cells was increased when they were treated with Red No. 3, which suggests that cellular DNA was damaged by this colorant.Red No. 3 increased binding of the ER from MCF-7 cells to the estrogen-responsive element.Consumption of Red No. 3, which has estrogenlike growth stimulatory properties and may be genotoxic, could be a significant risk
Sympathectomy 'Unwarranted' in Arteriosclerosis
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract LB-084: Human T-cell lymphoma invasion and metastasis 2 promotes chronic inflammation mediated tumorigenicity
Authors: Ya-Lin Chan, Wei-Chung Lai, Shaw-Jenq Tsai, H. Sunny Sun
Journal: Cancer Research (2019)

Abstract Cancer development is a very complex, multi-step process with mechanisms largely unknown. Despites numerous efforts in identifying many oncogenes and tumor suppressor genes that contribute to the development of cancers, the etiology of cancer remains poorly understood. Our previous studies showed the ectopic expression of human T-Cell Lymphoma Invasion and Metastasis 2, variant b (TIAM2S) in liver cells promotes liver cancer tumorigenesis. Nevertheless, the mechanism that underlies its oncogenic effect remains unclear. This study aims to investigate the role of TIAM2S in spontaneous and carcinogen-induced tumorigenesis. We established TIAM2-overexpressing transgenic (TG) mouse lines and characterize the genotypes and phenotypes of these transgenic mice in great details. In addition, we apply azoxymethane (AOM)-induced colon cancer model to examine the tumor susceptibility in these TG mice. We found that TIAM2S expressed murine model developed chronic inflammation and resulted in high incidence of lymphocytic infiltration in various organs. Furthermore, AOM-induced colon tumor developing in younger age of TG mice compared to the WT. Through the examination of immune cells and cytokine/chemokine profiles, we found that serotonin-mediated chronic inflammation, especially IL-23+/IL-17+/CD8+ T lymphocytes were characterized in the tertiary lymphoid organs in the TG mic. Altogether, this study demonstrate that TIAM2S mediates chronic inflammation and increases the susceptibility of colon cells to environmental hit and lead to the development of colon cancer. Citation Format: Ya-Lin Chan, Wei-Chung Lai, Shaw-Jenq Tsai, H. Sunny Sun. Human T-cell lymphoma invasion and metastasis 2 promotes chronic inflammation mediated tumorigenicity [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr LB-084.
Minerva Medica, Turin
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Voice Recognition
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Osteonecrosis of the Jaw and Bisphosphonates
Journal: New England Journal of Medicine (2005)

On page 2527, in the left-hand column, lines 15 through 17 of the third full paragraph should have read ". . .they have a similar benefit after primary angioplasty for acute ST-elevation myocardial infarction," rather than "for acute non-ST-elevation myocardial infarction," as printed.
Experimental Aspects of Hepatic Regeneration
Authors: Nancy L. R. Bucher
Journal: New England Journal of Medicine (1967)

AN attribute of the liver that continues to fascinate investigators is its latent capacity for growth. Mature liver cells are long-lived and, in rats and mice at least, may even survive for the adult life of the animal (approximately 1 mitosis is seen in 10,000 to 20,000 hepatocytes, about enough to keep up with the continuing body growth in these species). The simple expedient of partial hepatectomy, a well tolerated and highly reproducible operation with essentially no mortality, sets in motion a burst of astonishingly rapid growth. This growth is precisely regulated; it tapers off and finally ceases when the . . .
Semaine des Hôpitaux: Ann Pédiat, Paris
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
GENERAL INFECTION WITH GONOCOCCUS.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinique médicale des enfants. Affections de l'appareil circulatoire.
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Just Words
Authors: Alexander Gode
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
help!
Authors: lady ace cockroach
Journal: JAMA (1971)

<i>to the editor</i>sir i noticed in your fine journal the ode to fergus the fly and as you seem sympathetic to the plight of intellectual insects everywhere i wondered if i might enlist your aid in tracing my uncle i am a humble cockroach niece of archy the cockroach whose vers libre poetry appeared in the columns of great metropolitan newspapers years ago uncle archy lived in the newspaper office and typed his works by bashing his head on the keys of the typewriter manual of course not electric it affected his mind and he ran away to southern california to live with some beat poets deserting me i was his ward perhaps the friends of the late fergus or other insect lovers among your readership know of cockroaches hanging around literary establishments without their niece i would appreciate any information