tbuckley/cabot-search huggingface dataset:
More To Learn from Mary's Story
Authors: Leo I. Stemp
Journal: Annals of Internal Medicine (1993)

Letters1 September 1993More To Learn from Mary's StoryLeo I. Stemp, MDLeo I. Stemp, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-5-199309010-00037 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Aoun's description of his illness with the acquired immunodeficiency syndrome [1] and Southwick's vignette [2] cogently put into words my own troubling experience as a fresh-out-of-fellowship attending that led me to lose interest in academic medicine, which originally held such promise and excitement. One of my mentors during fellowship training told me that I was not focusing enough on the clinical care of patients. Focusing resulted in noticeably improved outcomes and improved clinical skill. My enjoyment of clinical medicine and taking care of patients grew as never before.Subsequently, I took a position at a prestigious institution ...References1. Aoun H. From the eye of the storm, with the eyes of a physician. Ann Intern Med. 1992; 116:335-8. Google Scholar2. Southwick F. Who was caring for Mary? Ann Intern Med. 1993; 118: 146-8. Google Scholar Author, Article, and Disclosure InformationAuthors: Leo I. Stemp, MD PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1993Volume 119, Issue 5 Page: 441-442 Keywords Academic medicine AIDS Anesthesia Blood Critical care Fellowships Intensive care units Patients Residency ePublished: 15 August 2000 Issue Published: 1 September 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Homosexuality
Authors: C. Allen
Journal: BMJ (1954)

<h3>Objective</h3> To develop a tool for estimating national trends in adult prevalence of sexually transmitted infections by low- and middle-income countries, using standardised, routinely collected programme indicator data. <h3>Methods</h3> The Spectrum-STI model fits time trends in the prevalence of active syphilis through logistic regression on prevalence data from antenatal clinic-based surveys, routine antenatal screening and general population surveys where available, weighting data by their national coverage and representativeness. Gonorrhoea prevalence was fitted as a moving average on population surveys (from the country, neighbouring countries and historic regional estimates), with trends informed additionally by urethral discharge case reports, where these were considered to have reasonably stable completeness. Prevalence data were adjusted for diagnostic test performance, high-risk populations not sampled, urban/rural and male/female prevalence ratios, using WHO9s assumptions from latest global and regional-level estimations. Uncertainty intervals were obtained by bootstrap resampling. <h3>Results</h3> Estimated syphilis prevalence (in men and women) declined from 1.9% (95% CI 1.1% to 3.4%) in 2000 to 1.5% (1.3% to 1.8%) in 2016 in Zimbabwe, and from 1.5% (0.76% to 1.9%) to 0.55% (0.30% to 0.93%) in Morocco. At these time points, gonorrhoea estimates for women aged 15–49 years were 2.5% (95% CI 1.1% to 4.6%) and 3.8% (1.8% to 6.7%) in Zimbabwe; and 0.6% (0.3% to 1.1%) and 0.36% (0.1% to 1.0%) in Morocco, with male gonorrhoea prevalences 14% lower than female prevalence. <h3>Conclusions</h3> This epidemiological framework facilitates data review, validation and strategic analysis, prioritisation of data collection needs and surveillance strengthening by national experts. We estimated ongoing syphilis declines in both Zimbabwe and Morocco. For gonorrhoea, time trends were less certain, lacking recent population-based surveys.
Vitamin D Deficiency in Homebound Elderly Persons-Reply
Authors: Jordan D. Tobin
Journal: JAMA (1996)

<h3>In Reply.</h3> —We appreciate the interest in our work and the opportunity to respond to the thoughtful comments of Dr Whit-more. There are many studies of vitamin D status in nonhomebound elderly, including the BLSA cohort.<sup>1-3</sup>The control population in our study consisted of a subset of the BLSA. Sherman et al<sup>3</sup>reported findings about the vitamin D status in this BLSA population in which participants were screened for diseases and for medications that affect calcium or vitamin D metabolism. The expected seasonal fluctuation was observed, but vitamin D status remained adequate. The vitamin D status also did not decline with age. In this population, without other factors interfering with vitamin D status, vitamin D deficiency generally does not occur. It is conceivable that differences in vitamin D status between the BLSA and other study groups exist because the BLSA represents a carefully screened, healthy ambulatory group. Other
Masthead
Authors: Steven Echard, David Cohen, New York, Rohit Loomba, San Diego, Lewis Roberts, Hugo Rosen, Los Angeles, Jayant Talwalkar, Gianfranco Alpini, Carl Berg, Mark Durham, Atlanta Czaja, Nicholas Ga, Laurie Louis, Los Deleve, Juan Angeles, Marc Ghany, Wolfram Goessling, Richard Boston, Daryl T-Y Green, Hongliang Lau, Cara Mack, Laura Nagy, Irene Cleveland, Hong Ng, Tushar Kong, Michael Patel, Vienna Trauner, James Consulting Biostatistician, Hepatology Dziura, Harmeet Elsewhere -Basic Sciences, Kathleen Malhi, Irwin Corey, Steven Schenker, San Antonio, Paul Berk, Ny Montgomery Bissell, San Francisco, Andres Blei, Keith Lindor, Michael Nathanson, Anna Rutherford, Mary Rinella, Hepatology Highlights, Robert Brown, Robert Schwartz, Sonal Kumar, Ann Haran, Jennifer Hutchinson, James Macdiarmid, Erica Lowe, Bianca Hughes, Emili Malatesta, Stefan Ryter, Leon Adams, Estella Alonso, Frank Anania, Atlanta Ga, Jesper Andersen, Marco Arrese, Gavin Santiago, Sumeet Arteel, Matias Dallas, Jesus Banales, San Sebastian, Meena Spain, New Bansal, Thomas York, Simon Beaven, David Brenner, Naga Chalasani, Zhi-Nan Chen, Ann-Lii Cheng, John Chiang, Srinivasan Dasarathy, Paul Cleveland, Atlanta Dawson, Adrian Ga, St Bisceglie, Wen-Xing Louis, Daiming Ding, China Xi'an, Gen-Sheng Feng, Peter Ferenci, Peter Fickert, Robert Fontana, Ann Arbor, Mi Francis, Michael Fuchs, Michael Gale, Chandrashekhar Ghandi, Bin Gao, Shannon Bethesda, Lucy Glaser, Valerie Golden, New Gouon-Evans, Arash York, Atlanta Grakoui, Haitao Ga, Grace Guo, Sanjeev Guo, Theo Gupta, Anne Heller, Jay Hoofnagle, Phillip Bethesda, Pietro Richmond, Hartmuth Jaeschke, Cynthia Ju, Binita Denver, Canada Toronto, Los Kaplowitz, Saul Angeles, Atlanta Karpen, Andrew Keaveny, Rohit Kohli, Anna Kramvis, Jennifer Lai, Michelle Lai, Frank Lammert, Anne Larson, Konstantinos Lazaridis, Josh Levitsky, Simon Ling, Anna Lok, Kathy Mi, Shelly Loomes, Los Lu, Marco Marzioni, Alex Miethke, Tim Morgan, Cynthia Moylan, Michael Durham, Mindie Co, Stanford Nguyen, Guang Ning, Ran Oren, Israel Jerusalem, K Reddy, Barbara Rehermann, Shari Rogal, Kirsten Sadler, Shiv Sarin, Bernd Schnabl, Robert Schwabe, Vijay Shah, Morris Sherman, Canada Siddiqui, Siddarth Singh, Carlo Spirli, Ben Stanger, Todd Stravitz, Frank Richmond, Puneeta Tandon, Canada Tapper, Emmanuel Thomas, Natalie Torok, Tram Davis, Emmanuel Tsochatzis, Lisa Vanwagner, Hugo Vargas, Elizabeth Verna, Silvia Vilarinho, Michael Volk, Loma Linda, Li Wang, Hongyang Wang, Fusheng Wang, David Wang, Kymberly Louis, Rebecca Watt, Holger Wells, San Willenbring, Allan Francisco, Vincent Bronx, Hong Wong, Min Kong, Mengwei You, San Zhang, Lars Antonio, Yanqiao Zhang, Jiajun Zhao, Huiping Zhou, Michael Fried, Jorge Bezerra, Meena Bansal, Bruce Luxon, Ronald Sokol, Raymond Aurora, Laurie Chung, Norah Angeles, San Terrault, Councilors-At-Large Francisco, John Lake, Lopa Mishra, David Mulligan
Journal: Hepatology (2019)
AB0378 Osteoarthritis is the Most Frequent Cause of Rheumathoid Arthritis Misdiagnosis in a Colombian Specialized Center
Authors: O. Andrade, D. Gomez, P. Santos-Moreno, G. Saavedra-Martinez
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Frequently, patients with osteoarthritis (OA) are misdiagnosed as rheumatoid arthritis (RA) in primary care centers, leading to wrong treatment and consequent clinical and health economics impact. <h3>Objectives</h3> The objective of this study was to describe demographic and clinical characteristics of a cohort of patients derived to a specialized RA center with presumptive RA diagnosis and finally diagnosed as osteoarthritis. <h3>Methods</h3> A descriptive cross sectional study. Patients were referred and assisted to a specialized RA center in a 36 month period with presumptive diagnosis of rheumatoid arthritis. Each patient was evaluated to confirm or rule-out diagnosis of RA as follows: a rheumatologist fulfilled a complete medical record, including joint counts; it was assessed rheumatoid factor and anti-citrullinated antibodies, and other laboratories depending on each case. Also were made x-rays of hands and feet, and in some cases of persistent doubt about the diagnosis was requested comparative MRI of hands or/and feet. Frequencies and percentages were calculated for the demographic and clinical characteristics of the cohort of patients in which the diagnosis of RA was ruled-out. <h3>Results</h3> From a total of 4780 Patients derived to specialized in RA center with presumptive RA diagnosis, after medical and laboratory evaluation 1875 (39.3%) had a wrong RA diagnosis; of them 1108 patients (59.1%) had finally osteoarthritis diagnosis. Of these patients 783 (70.6%) were women and 325 (29.3%) men, with an average age of 57.4 (±12 years). Majority of these patients were followed by general physicians or internists and treated with non-biologic and biologic disease modifying anti-rheumatic drugs (DMARDs) in the past years, for an average time of 4.5 years. <h3>Conclusions</h3> In this cohort of patients the most frequent diagnosis of patients misdiagnosed with RA was osteoarthritis, being more than two thirds of them, predominantly women. This shows the need for the implementation of specialized clinics in RA and educational strategies for primary care physicians in order to avoid the impact of this wrong diagnosis. <h3>Disclosure of Interest</h3> None declared
Perinatal bereavement.
Authors: S Bourne, E Lewis
Journal: BMJ (1991)

<h3>Abstract</h3> Transforming data from genome-scale assays into knowledge of affected molecular functions and pathways is a key challenge in biomedical research. Using vocabularies of functional terms and databases annotating genes with these terms, pathway enrichment methods can identify terms enriched in a gene list. With data that can refer to intergenic regions, however, one must first connect the regions to the terms, which are usually annotated only to genes. To make these connections, existing pathway enrichment approaches apply unwarranted assumptions such as annotating non-coding regions with the terms from adjacent genes. We developed a computational method that instead links genomic regions to annotations using data on long-range chromatin interactions. Our method, Biological Enrichment of Hidden Sequence Targets (BEHST), finds Gene Ontology (GO) terms enriched in genomic regions more precisely and accurately than existing methods. We demonstrate BEHST’s ability to retrieve more pertinent and less ambiguous GO terms associated with results of <i>in vivo</i> mouse enhancer screens or enhancer RNA assays for multiple tissue types. BEHST will accelerate the discovery of affected pathways mediated through long-range interactions that explain non-coding hits in genome-wide association study (GWAS) or genome editing screens. BEHST is free software with a command-line interface for Linux or macOS and a web interface (http://behst.hoffmanlab.org/).
THE CARE OF PATIENTS WHO WORK
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE PHYSICIAN AND THE AMERICAN MEDICAL EDUCATION FOUNDATION
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Do Moral Principles Change?—
Journal: JAMA (1883)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Uterotonic drugs have no adverse effects on cognitive function
Journal: BMJ (1999)

Adverse prenatal and perinatal factors are associated with schizophrenia of early onsetIn order to investigate the role of prenatal and perinatal risk factors in the development of schizophrenia and affective and reactive psychosis in early adult life, Hultman et al (p 421) carried out three population based, case-control studies using the Swedish birth and inpatient registries.Adverse prenatal and perinatal factors were more common in patients with schizophrenia than in controls and seemed more important in the aetiology of early onset schizophrenia than in affective and reactive psychosis.Multiparity, bleeding during pregnancy, and small size for gestational age were associated with a threefold to fourfold increased risk for schizophrenia among males.The authors conclude that the mechanism underlying the increased risk remains unknown but ischaemic brain damage secondary to placental insufficiency is one possibility.
Amelioration of Postischemic Reperfusion Injury by Antiarrhythmic Drugs in Isolated Perfused Rat Lung
Authors: Kumuda C. Das, Hara P. Misra
Journal: Environmental Health Perspectives (1994)

Antiarrhythmic drugs, such as lidocaine, quinidine, and procainamide, have been shown to be effective against postischemic reperfusion injury in isolated rat lungs.Rat lungs were perfused at a constant flow with Krebs-Henseilet buffer supplemented with 4% bovine serum albumin and ventilated with air containing 5% CO2.The lungs were subjected to ischemia by stopping perfusion and ventilation for 60 min followed by 30 min of reperfusion.Lung injury was determined by measuring the increase in wet-to-dry lung weight ratio, while pulmonary arterial pressure and peak air- way pressure were calculated from the pre-and postischemic differences.Lidocaine, quinidine, and procainamide at doses of 5, 10, and 20 mg/kg body weight, respectively, were found to attenuate the postischemic lung injury significantly (p<0.0001).The formation of cyclooxygenase products, which were elevated during reperfusion, was also significantly (p<0.0001)inhibited by these drugs.Since these antiarrhythmic agents are found to be powerful scavengers of hydroxyl radicals and can prevent membrane lipid peroxidation, these findings suggest that the antioxidant properties of these drugs may, in part, be responsible for protecting the lungs against reperfusion injury.
Epithelial Ovarian Cancer Metastasizing to the Brain: A Late Manifestation of the Disease With an Increasing Incidence
Authors: D. F. Kolomainen
Journal: Journal of Clinical Oncology (2002)

PURPOSE: We present the Royal Marsden Hospital experience of cerebral metastases from primary epithelial ovarian carcinoma (EOC) over the last 20 years and examine the evidence for an increasing incidence of EOC metastasizing to this site. PATIENTS AND METHODS: A total of 3,690 women with EOC were seen at the Royal Marsden Hospital from 1980 to 2000. Eighteen of these patients developed cerebral metastases. RESULTS: Median age at diagnosis of EOC was 52 years (range, 39 to 67). All patients received at least one line of platinum-based chemotherapy; 56% (10 of 18) received more than one line of treatment; 17% (three of 18), two lines; 11% (two of 18), three lines; and 28% (five of 18), four lines. The median treatment interval between each line of chemotherapy was 12, 18, and 4 months. The median interval between diagnosis and CNS relapse was 46 months (range, 12 to 113), in comparison with 5 and 7.5 months for hematogenous relapse in lung or liver, respectively (P < .001). The incidence of CNS metastases in our population from 1980 to 1984 was 0.2%; from 1985 to 1989, 0%; from 1990 to 1994, 0.3%; and from 1995 to 1999, 1.3% (P < .001). An analysis of data from the literature also suggests that the incidence of cerebral metastases from EOC has increased over time. CONCLUSION: CNS metastases in EOC are a rare and late manifestation of the disease, occurring in patients with a prolonged survival caused by repeated chemosensitive relapses. An analysis of our data and the data from the literature suggests that the incidence of metastasis at this site in patients with EOC is increasing.
Advances continue in sickle cell disease
Authors: Barbara Bolsen
Journal: JAMA (1982)

Despite the fact that sickle cell disease has long been understood at the molecular level, there is insufficient knowledge about the natural history of the disease, and preventive or curative treatment has not been found. The disease afflicts about 50,000 Americans, mostly black, and thousands of Africans, Arabs, Indians, Greeks, and Italians. Investigators at a recent scientific meeting reported progress on several fronts: a low-risk method for prenatally detecting the disease in all cases; a look, for the first time, at the behavior of sickle hemoglobin inside human RBCs; a method of drug delivery designed to minimize toxic side effects; and an ongoing study to characterize the clinical course of the disease. <h3>Prenatal Detection</h3> Using a restriction enzyme that, like all such enzymes, always cuts DNA in the same place (in this case a certain location on the β-globin gene), investigators at the University of California, San Francisco, can now
Zoledronic acid (Z) as palliative treatment in cancer patients with bone metastases: Interim results of a prospective, open-label trial
Authors: A. Kretzschmar, T. Wiegel, S. E. Al-Batran, H. F. Hinrichs, M. Kindler, T. Steck, H. J. Illiger, U. Haus, A. Kirner, G. Ehninger
Journal: Journal of Clinical Oncology (2004)

8140 Background: Bone metastases in cancer patients may lead to severe bone pain, pathological fractures, and hypercalcemia. The development of osteolytic destruction is due to activation of osteoclasts by release of tumor-derived stimulating factors. The bisphosphonate (BP) Z is known to inhibit osteoclast function and thus to alleviate the adverse effects of tumor-induced increase in osteoclastic bone resorption. We investigated the effects of Z in patients with bone metastases in a broad range of tumor types Methods: BP-naive patients with at least one detectable bone lesion irrespective of the primary tumor were eligible for enrolment in this prospective, multicenter study with a single treatment arm, in which patients receive Z at a dose of 4 mg every 3–4 weeks for a maximum of 12 infusions. Primary study endpoints are the treatment-emergent changes in pain sensation assessed by a 100 mm visual analog scale (VAS) for bone pain, and in the concomitant consumption of analgesics, assessed by a five-point scale ranging from 0–4 in according to the analgesic capacity (both documented by a patient diary). Here, we present the data of an interim analysis after 24 weeks. Results: 606 patients in 67 centers have been included. 408 of them were valid for the efficacy analysis (non-validity mostly due to missing data from patient diaries). The age of this subset (61% females) ranged from 31–90 years. Predominant types of primary cancer were breast (49%) and prostate cancer (18%). 319 patients regularly completed treatment up to Week 24. The mean VAS value for pain decreased by 13.8 ± 30.6 from 36.9 ± 28.2 to 23.1 ± 23.8 (p<0.0001, t-test, ("last observation carried forward" procedure for drop-outs). Accordingly, the mean analgesic score not only remained stable, but even decreased by 0.37 ± 1.30 from 1.65 ± 1.56 to 1.28 ± 1.61 (p<0.0001, t-test). Conclusions: Based on the presented results, we conclude that treatment of bone metastases in a broad range of tumor types with Z acid provides substantial benefit to cancer patients also in terms of pain relief and thus improves their quality of life. (supported by Novartis Pharma GmbH, Nürnberg, Germany) Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Novartis Pharma GmbH Germany
Subcutaneous Apomorphine for Neuroleptic Malignant Syndrome
Authors: LORENZO LATTANZI , M.D., FRANCESCO MUNGAI , M.D., ANNA , ROMANO , M.D., UBALDO BONUCCELLI , M.D., GIOVANNI B. CASSANO , M.D., ANDREA FAGIOLINI , M.D.
Journal: American Journal of Psychiatry (2006)