tbuckley/cabot-search huggingface dataset:
Abstract 1975: Multivariate exome analysis identifies CXCR5-CXCL13 signaling as a key driver in early breast cancer development and prognosis
Authors: Courtney D. Dill, Tiara Griffen, Corey Young, Kaylin Carey, James W. Lillard
Journal: Cancer Research (2019)

Abstract Breast cancer (BrCa) is the most frequently diagnosed cancer and the second leading cause of cancer-related death among women worldwide despite new developments in prevention and treatment. More recently, rapid increases in BrCa incidence have been reported in countries of the Asia-Pacific region. Age of diagnosis in Asian BrCa patients is much younger than age of diagnosis in western countries, such as the United States, and Asian early BrCa patients tend to be pre-menopausal, whereas only 15-30% of western BrCas are pre-menopausal. The mechanisms responsible for early BrCa remain unknown. Furthermore, it remains controversial whether early breast cancer has unique tumor biology. The goal of this study was to characterize the molecular phenotype of early BrCa in the context of CXCL13, CXCR5 and associated gene expression. We hypothesized that CXCR5-CXCL13 signaling contributes to the aggressive phenotype of early BrCa. A bioinformatic approach was used to aid in characterizing this condition. Our patient cohort data (50 females of Korean descent, age ≤ 35 years) was obtained from The International Cancer Genome Consortium (ICGC). DESeq analysis was used to identify genes differentially expressed among normal tissue and primary tumor groups. Weighted Gene Network Co-expression (WGCNA) analysis was carried-out to identify gene networks associated with factors influencing BrCa prognosis. Finally, canonical pathway, upstream regulator, and gene interaction analysis was conducted using Ingenuity Pathway Analysis. Our data show CXCL13, CXCR5, and associated genes (LTA, LTB, IL10, IL27RA, TNFRSF13B, TNFRSF17, and TNFRSF9), which have been previously shown to drive tertiary lymphoid structure (TLS) formation, were significantly associated with the molecular phenotype of early BrCa in our patient cohort. Taken together, our findings suggest TLSs contribute to the tumor immune microenvironment and contribute to early BrCa progression. Citation Format: Courtney D. Dill, Tiara Griffen, Corey Young, Kaylin Carey, James W. Lillard. Multivariate exome analysis identifies CXCR5-CXCL13 signaling as a key driver in early breast cancer development and prognosis [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1975.
Phase I and pharmacological study of oral topotecan and the BCRP and P-gp inhibitor elacridar
Authors: J. H. Schellens, I. E. Kuppens, R. C. Jewell, S. A. Radema, E. O. Witteveen, E. M. Paul, S. G. Mangum, H. Rosing, J. H. Beijnen, E. E. Voest
Journal: Journal of Clinical Oncology (2004)

2003
Distal Axonopathy: One Common Type of Neurotoxic Lesion
Authors: Peter S. Spencer, Herbert H. Schaumburg
Journal: Environmental Health Perspectives (1978)

Neurotoxic chemicals commonly produce retrograde degeneration of the axons of long and large nerve fibers in the central and peripheral nervous system. This produces a clinical picture of polyneuropathy in man and animals in which sensory and motor disturbances develop in the feet and hands then progress with time to the legs and arms. Distal axonopathy, as the underlying pathologic process is termed, is one of four principal types of neurotoxic diseases, the others including degeneration of neurons (neuronopathy), myelin sheaths (myelinopathy) and damage to the neurovasculature (neurovasculopathy). In the experimental animal, these four types of neurotoxic diseases can be distinguished by examining selected areas of brain and nerve tissues prepared by contemporary methods of tissue fixation. These procedures may form the basis of a new and sensitive assay for neurotoxicity.
The Heart
Authors: Alice Jones
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Treating MCL with CAR T Cells
Journal: Cancer Discovery (2020)

Abstract KTE-X19, an investigational chimeric antigen receptor T-cell therapy, has shown promising efficacy in patients with relapsed/refractory mantle cell lymphoma. Based on data from the ZUMA-2 trial, it is now under the FDA's priority review and could soon be a new standard of care for this rare hematologic malignancy.
Evaluation of cancer patients’ perspectives on weight management counseling at a comprehensive cancer center.
Authors: Damien Mikael Hansra, Cynthia Daniels, Ricardo H. Alvarez
Journal: Journal of Clinical Oncology (2019)

221 Background: Being overweight (OW) or obese (OB) is a risk factor for a variety of cancers &amp; denotes a worse prognosis for some. Strategies on management of OW &amp; OB patients (pts) are lacking. Data shows majority of physicians are OW &amp; OB &amp; confidence in OB counseling in these individuals is less compared w/ normal weight (NW) counterparts. Here we report results of a survey on cancer pt’s opinions on weight management. Methods: Pts asked to complete a 20-question (Q) survey. Clinical info collected: age, race, cancer type, weight class (underweight, NW, OW, OB, unsure but likely overweight). Survey Qs ask about optimal timing of weight counseling. Also, Qs regarding importance of their oncologists (ONCO) BMI assessed. Other Qs about pt risk factors for obesity, pt willingness, &amp; pt preferred modalities to change dietary &amp; exercise habits also assessed. Stats: 1-way ANOVA &amp; students' T-test used to compare responses. P-value α = 0.05 used. Results: 245 pts completed the survey. Main Qs: Best time for ONCO to address weight with pts is? “Anytime” 45% (111/245), “First visit” 27% (65/245), “After main treatment” 27% (65/245), “Never” 1% (2/245) p &lt; 0.01. Who would you listen to MOST about weight loss advice? “NW ONCO” 41% (101/245), “BMI of my ONCO does not matter” 53% (131/245), “OB or OW” 5% (13/245) p &lt; 0.01. Pts tend to; "eat less healthy when stressed": true 77% (189/245) vs false 23% (56/245) p &lt; 0.01; "eat less healthy when sad or depressed": true 72% (176/245) vs false 28% (69/245) p &lt; 0.01; "exercise less since cancer diagnosis" true 61% (150/245) vs false 39% (95/245) p &lt; 0.01. Pts are willing to change "dietary habits to induce weight loss": yes 94% (231/245) vs no 6% (14/245) p &lt; 0.01; "exercise habits to induce weight loss": yes 96% (234/245) vs no 4% (11/245) p &lt; 0.01. Results of clinical, demographics, other Qs included in presentation. Conclusions: Almost all pts would like to discuss weight loss on the first visit or after main treatment completed. Almost all pts are willing to change dietary &amp; exercise habits. Also, most pts would like to receive counseling by their ONCO regardless of their ONCO’s weight. Furthermore, early interventions into pt's psychological health &amp; exercise habits may benefit pts in weight management.
The Medical Department of the United States Army in the World War. Volume XI, Surgery. Part Two.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Genetically—Determined Disease Found In Corneal Grafts
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Accumulation of HCV-core specific T cell clonotypes in patients with chronic hepatptis C and its reduction following eradication of HCV-RNA by antiviral treatment , Hiroto Kita�, Masao Takatori?, Shingo Iwabuchi?, Kiyoshi Kurokawa#, Michio ImawariI, Kusuki Nishioka*, Shiro Iino*, and Kazuhiko Yamamoto*. *Inst. of Med. Sci. and ?Second Dept. of Ind. Med., St. Marianna Univ., School of Medicine, Kanagawa, Japan; ILiver Study Lab., Iichi Univ., School of Medicine, Tochigi, Japan; and #First and …
Journal: Hepatology (1995)
THE CHANGING RECORDS OF MORTALITY
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Purification of Pituitary Gonadotropin from Urine of Eunuchs
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Stat Bite: Probability of Developing Invasive Cancers Over Selected Ages, 2000–2002
Journal: JNCI Journal of the National Cancer Institute (2006)

Though women have a slightly higher probably of developing invasive cancer before age 60, men quickly move into first place after age 60.They have a higher chance of developing cancer overall.For men, the most common lifetime risk comes from invasive prostate cancer (1 in 6), while in women the most common is breast cancer (1 in 8).Lung and colon/rectal cancer come in second and third for both men and women.
Paraffin Prosthesis
Authors: Tyler Marion, Kevin Cao, Jorge Roman
Journal: JAMA Dermatology (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Continuous negative chest-wall pressure. Successful use for severe respiratory distress in an adult
Authors: S. K. Sanyal
Journal: JAMA (1976)

Continuous negative pressure (CNP) around the chest-wall and lower parts of the body was used to treat progressively severe hypoxemia in a spontaneously breathing adult with diffuse alveolar disease. Therapy with CNP produced a substantial increase in arterial oxygen tension that was sustained and permitted a decrease in oxygen requirements to 40% within 24 hours. There were concomitant decreases in intrapulmonary right-to-left shunt and respiratory frequency. During CNP therapy, no adverse effects on heart rate or blood pressure were detected. (<i>JAMA</i>236:1727-1728, 1976)
Hyperlipidemia in liver transplant patients: Persistence with long-term follow-up JS Crippin, BL Foster, SL Carlen, L Jennings, T Gonwa, R Goldstein, M Levy, B Husberg, G Klintmalm. Baylor University Medical Center, 3500 Gaston Avenue, Dallas, Texas, 75246
Journal: Hepatology (1993)
Microangiopathic hemolytic anemia associated with pulmonary adenocarcinoma
Authors: D. Podzamczer
Journal: JAMA (1985)

<h3>In Reply.—</h3> I read the letter of Dr Ertel with interest and appreciate the opportunity to respond to it. At Ford Hospital, we have also seen a case wherein the first manifestation of recurrent Graves' disease after methimazole treatment was a recurrence of the patient's urticaria and angioedema. There was no mention of urticaria or angioedema in the second case Dr Ertel described, but it was important for the relationship with the severe pruritus to be recognized as hyperthyroidism. At no point in my original response did I emphasize the rarity of the association between urticaria and hyperthyroidism, but I did state that it was uncommon. In fact, as stated, I routinely order tests to assess thyroid function in patients presenting to the allergy clinic with urticaria, especially in young females, in whom thyroid disease is more commonly seen. Difficulty arises in the older patient, in whom the clinical features
Abstract 17354: A Canadian Pilot Randomized Controlled Trial for a Decision Support Intervention in de novo Implantable Cardioverter Defibrillator Candidates - Main findings
Authors: Sandra Carroll, Michael H McGillion, Dawn Stacey, Jeff S Healey, Gary Foster, Sarah A Hutchings, Heather M Arthur, Heather M Arthur, Gina Browne, Lehana Thabane
Journal: Circulation (2015)

Introduction: Patient decision aids (PtDA) support quality decision making and improve patient reported outcomes. This pilot randomized controlled trial aimed to evaluate the use of an ICD specific PtDA on patient’s decisional conflict and ICD knowledge. Methods: In accordance with the International Patient Decision Aid Standards (IPDAS), a PtDA was developed. We conducted a single-centre non-blinded RCT with concealed allocation to evaluate the effect of a PtDA in patients offered an ICD for primary prevention. Exclusions: 1) inability to read English and complete a PtDA, 2) ICD for secondary prevention, 3) biventricular devices. Consented patients were randomized to 1) usual care, 2) PtDA intervention. Prior to specialist consultation the PtDA intervention group received the PtDA. The primary outcome of decisional conflict was measured before consultation and post-ICD implantation. The decisional conflict scale measures patient’s perception of difficultly making a decision, uncertainty regarding the decision and factors contributing to uncertainty. Higher scores are indicative of greater decisional conflict. Knowledge was measured as a secondary outcome using 5 questions related to ICD treatment, benefits and risks. Results: Eighty-two patients were randomized to usual care (n=41) or PtDA intervention (n=41). Mean age (SD) was 66.76 (11.05), 27% female. Baseline characteristics between groups were balanced. Patients receiving the PtDA intervention scored significantly lower on the DCS scale with a total mean score of 27.32 (18.37) when compared to usual care, scoring 49.53 (18.62) (p&lt;0.0001). This difference remained post implantation, 21.16 (11.71) PtDA intervention, 29.89 (13.32) usual care, (p=0.0041)). The PtDA intervention group were more knowledgeable, with 47.50% scoring greater than 3/5 of the knowledge questions correct, compared to 23.09% receiving usual care (p=0.023). Conclusion: The results of this pilot study suggest that use of an ICD-specific PtDA reduced patient’s decisional conflict both pre and post implantation and improved knowledge. In the context of making decisions regarding life prolonging interventions, our findings suggest evidence based decision support results in improved patient decision quality.
The Sphingolipidoses
Authors: Roscoe O. Brady
Journal: New England Journal of Medicine (1966)

THE sphingolipidoses comprise a group of inherited metabolic diseases characterized by the accumulation of excessive quantities of certain glycolipids or phospholipids in various tissues of the body. These lipids have a common basic structure called ceramide (Fig. 1, line 1) consisting of the long-chain amino alcohol sphingosine acylated with a fatty acid on the nitrogen atom of sphingosine.Recent significant advances have provided considerable insight into the nature of the metabolic aberrations in several of the sphingolipidystrophies. This progress is due to a large extent to the application of newly developed technics for the chemical synthesis of specifically labeled sphingolipids. . . .
AN ANTICIGARETTE MOVEMENT IN SPAIN.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Midwifery for Nurses
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal