tbuckley/cabot-search huggingface dataset:
Coral Ulcer
Authors: J. L. Hardman
Journal: BMJ (1950)

<h3></h3> <b>Background:</b> Patellar instability is a common orthopedic condition in the pediatric population. Many factors contribute to patellar instability, including trochlear dysplasia. However, patellar instability and its treatments are not well documented in the literature for patients with osteogenesis imperfecta. <b>Case Report:</b> After medial patellofemoral ligament (MPFL) reconstruction, a 17-year-old male with osteogenesis imperfecta had a patellar dislocation that resulted in a patellar fracture. The patient subsequently had a revision of his MPFL reconstruction, and at 2½ years postoperation has had no episodes of recurrent patellar instability. <b>Conclusion:</b> The combination of bone fragility, trochlear dysplasia, and strength of the allograft used for MPFL reconstruction compared to the patient9s bone strength led to dislocation and patellar fracture. Research into alternative methods for patellar fixation and postoperative physical therapy protocols for patients with osteogenesis imperfecta is needed. Special considerations must be made for this patient population.
DSM-III. Implications for liaison psychiatry and psychosomatic medicine
Authors: L. Linn
Journal: JAMA (1982)

FOR DECADES, psychiatry and the rest of medicine have been locked in an unhappy courtship, unable to live together and yet unable to live apart. In periodic self-assessments, psychiatrists acknowledge that they have let their general medical skills get rusty, and nonpsychiatrist physicians, on their part, admit that they ignore, too often, crucial psychosocial issues in their care of patients. Ironically, both camps accept the need for a holistic medical point of view, that is, an approach to patient care that simultaneously encompasses all the biologic, psychological, and social factors that affect a given patient; although both camps have paid lip service to it, they have thus far failed to achieve that goal.<i>The Diagnostic and Statistical Manual of Mental Disorders</i>(ed 3) (<i>DSM-III</i>) can be the long sought for unifying catalyst. <i>DSM-III</i>is the title of the most recently issued edition of the diagnostic and statistical manual of the
Erythromycin for anaerobic pleuropulmonary and soft-tissue infections
Authors: E. J. Goldstein
Journal: JAMA (1979)

Erythromycin has been reported to be active in vitro against most anaerobic bacteria. We found it effective in treating 14 of 17 patients with mild to moderately severe anaerobic or mixed aerobic/anaerobic pleuropulmonary or soft-tissue infections when adjunctive measures (eg, drainage, débridement, and the use of additional antibiotics to treat important aerobic pathogens) were employed. Erythromycin offers a reasonable therapeutic alternative to penicillin in the treatment of a penicillin-allergic patient who has a mild or moderately severe anaerobic or mixed aerobic/anaerobic infection not involving Bacteroides<i>fragilis</i>or fusobacteria. (<i>JAMA</i>242:435-438, 1979)
Adolescent Pregnancy
Authors: Martin T. Donohoe
Journal: JAMA (1996)

<h3>To the Editor.</h3> —Ms Spitz and colleagues<sup>1</sup>document persistently high rates of adolescent pregnancy in the United States, and Dr Litt<sup>2</sup>mentions many of the factors responsible, including poverty and limited access to contraceptives. However, neither article adequately describes the scope and magnitude of these and other factors involved. Forty percent of US girls live near or below poverty income levels, and these individuals account for 6 of 7 births to teenagers.<sup>3</sup>Adolescent pregnancy rates in the United States are 3 to 10 times higher than those found among industrialized nations of Western Europe, and poverty rates among US youths are higher by a similar magnitude. In areas of the United States with adolescent poverty rates as low as those in Western Europe, adolescent pregnancy rates are similarly low.<sup>3</sup> Access to contraceptives remains limited. While more than 50% of high school-aged adolescents are sexually active, only
Massachusetts Medical Society
Authors: John Figgis Jewett
Journal: New England Journal of Medicine (1955)

COMMITTEE ON MATERNAL WELFARERupture of the Uterus, with Hemorrhage and ShockA twenty-seven-year-old gravida V, para III, was admitted at term in early labor. She was obese and had had excessive weight gain with all three prior pregnancies, delivering babies weighing as much as 4.2 kg. and gaining 22.7 kg. with one pregnancy. She was Rh negative, with a rising titer of antibodies, but her weight rose only from 82.1 to 89.8 kg. in the current pregnancy and she experienced an otherwise uneventful course.Admitted at 6 a.m. in early labor, she had intact membranes; no fetal heart beat . . .
From &lt;emph type="ital"&gt;JAMA&lt;/emph&gt; ’s Daily News Site
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Omitted Name and Affiliation of International Group Member
Authors: Franz Messerli
Journal: JAMA Internal Medicine (2019)

Sean J. Barbour, MD, MSc; Rosanna Coppo, MD, FERA; Hong Zhang, MD, PhD; Zhi-Hong Liu, MD; Yusuke Suzuki, MD, PhD; Keiichi Matsuzaki, MD, PhD; Ritsuko Katafuchi, MD, PhD; Lee Er, MSc; Gabriela Espino-Hernandez, MSc; S. Joseph Kim, MD, PhD; Heather N. Reich, MD, PhD; John Feehally, FRCP; Daniel C. Cattran, MD, FRCPC; International IgA Nephropathy Network
Endothrix Ringworm
Authors: Harold L. Saferstein
Journal: JAMA (1965)

<h3>To the Editor:—</h3> The communication by Saferstein et al in the Nov 30, 1964, issue ofThe Journalon endothrix ringworm gives evidence of the steadily increasing interest in careful mycological investigations. Other than reference to an excellent textbook, there is no evidence that the authors surveyed the pertinent literature. Endothrix ringworm may be a "new public health problem in Philadelphia," but this disease should not be referred to any longer as "an uncommon disease in the northern part of the United States." In my report "Trichophyton Tonsurans Ringworm: Contribution to Epidemiology and Rare Clinical Manifestations" (<i>Brit J Derm</i><b>66</b>: 229, 1954) reference is made to several papers dealing with this type of infection in New York City, including our own observation at Bellevue Skin Clinic. In a six-year period (1947-1953), we found a total of 44 patients with<i>T tonsurans</i>infection. Moreover, seven patients at the Mt. Loretta Home,
Peritoneal lavage and abdominal trauma
Authors: E. A. Deitch
Journal: JAMA (1983)

In general, patients who have sustained abdominal trauma can be separated into one of three groups: those with obvious life-threatening injuries, those with obvious nonimmediate life-threatening injuries, and those with equivocal or normal physical examination results in whom intra-abdominal injury is possible. In the first two groups, operative intervention is mandatory. The decision as to which patients in the last group require operation has plagued the surgeon for years. These patients may have severe intra-abdominal injuries and normal abdominal examination results, especially if the sensorium is depressed. In contrast, a patient with severe abdominal pain and tenderness may not have an intra-abdominal injury. Because of these difficulties, Root et al,<sup>1</sup>in 1965, used peritoneal lavage to diagnose intra-abdominal injuries in patients sustaining blunt trauma. Since then, many studies have been performed evaluating this screening test in patients with both blunt and penetrating trauma. Almost universally, these studies have shown
Editorial Board
Authors: George Bartley, Henry Jampel, Daniel Albert, Andrew Schachat, Anita Agarwal, T Iqbal, Ike Ahmed, Jayakrishna Ambati, Tin Aung, Ed Singapore, Boel Bengtsson, James Brandt, Wiley Chambers, Michael Chiang, Emily Chew, Marjan Farid, Steven Gedde, Mingguang He, Ronald Klein
Journal: Ophthalmology (2014)
CRITIQUE OF MACROSCOPIC EXAMINATION OF SPECIMENS REMOVED IN THIRTY-TWO CONSECUTIVE LAPAROTOMIES.
Authors: F. BYRON ROBINSON
Journal: JAMA (1894)

The modern success in abdominal surgery excites the admiration of all. It is the outcome of systematic experiments, observation and reasoning. Its success at one time was thought to be due to antiseptics, i.e., chemic solutions which destroyed a vegetable germ. But we know to-day that simple cleanliness accomplishes all. We obtain cleanliness to-day by heat and water, two simple elements. The spray and chemic lotion have passed into oblivion with many others found not essential. Modern research sifts matters until essentials are found and non-essentials are eliminated. The most delicate of all surgery is that of the peritoneum, which is almost as important to the human economy as the brain. The immediate and remote effects of urgery on the peritoneum should be always held in mind. The greatest of lymph sacs brooks no insults without records. The peritoneum surrounds the visceral organs which hold body and soul together by
EM Changes and Other Toxic Effects of FireMaster BP-6 (Polybrominated Biphenyls) in the Mouse
Authors: T. H. Corbett, J. L. Simmons, H. Kawanishi, J. L. Endres
Journal: Environmental Health Perspectives (1978)

Groups of Swiss ICR mice were fed 1000 ppm polybrominated biphenyls (FireMaster BP-6) in rodent chow for 4, 8, 11, and 14 days. Control groups were fed standard rodent chow without FireMaster BP-6. Animals were killed at the end of each feeding period and the livers examined by electron microscopy. EM changes noted were progressive increase in size of hepatocytes, a decrease in rough endoplasmic reticulum, a marked increase in smooth endoplasmic reticulum, mitochondrial degeneration, increased lysosomes, and a decrease in glycogen. In addition, there was increasing proliferation of microvilli in bile canaliculi with increasing feeding times. A group of mice fed 1000 ppm FireMaster BP-6 in rodent chow for 11 days had livers with a mean of 13.93% of total body weight as compared with 6.49% for the control group (P=0.02). Tissue distribution following ingestion of 100 ppm FireMaster BP-6 for 14 days was studied. Twelve weeks post-feeding, the tissue concentrations of hexabromobiphenyl in order of highest concentration to lowest were as follows: perithymic fat, perirenal fat, adrenal glands, thymus gland, liver and stomach.
Prospective comparison of three non-invasive tests for pancreatic disease
Authors: P N Foster, J Kelleher, C J Mitchell
Journal: BMJ (1984)

Ultrasonography, computed tomography (CT), and an oral pancreatic function test were evaluated prospectively in 107 consecutive patients suspected of having pancreatic disease, the final diagnosis being made independently of these tests.Seventeen patients proved to have either chronic pancreatitis or a pancreatic neoplasm.Five had an unfused ventral pancreas and 10 had "minimal change" pancreatograms.Seventy five patients did not have pancreatic disease.Among the 17 patients with pancreatic disease the sensitivities of ultrasound, CT, and the pancreatic function test were 70%, 71%, and 76% respectively; among those without disease values of specificity of the three tests were 75%, 87%, and 72%.All three tests failed to detect most of the patients with unfused ventral pancreases or minimal change pancreatograms.The predictive values of a positive result for the three tests were 43%, 67%, and 34%.The predictive value of a
Small anal tumors irradiated via rectoscope
Authors: M. Korcok
Journal: JAMA (1981)

An intracavitary radiation device that can slip inside a rectoscope and quell small, localized rectal tumors into submission is providing a safe and effective alternative for patients in whom anorectal surgery may be contraindicated. The device, a low-voltage contact unit that keeps 80% to 90% of the x-ray beams to within 2 cm of the target tissue, has yielded an 85% complete tumor regression rate in patients treated for small, well-defined rectal carcinomas at the Cleveland Clinic Foundation. Gwynn L. Jelden, MD, staff physician in the foundation's department of radiation therapy, told the recent meeting of the American Society of Therapeutic Radiologists in Miami Beach that the intracavitary regimen should be considered only for carefully selected patients with small cancers of not more than 3 cm in diameter and a low probability of lymph node involvement. Additional reasons for assigning patients to the treatment may be advanced age, cardiac or
Convulsions After Carotid Endarterectomy
Authors: J. Terry Wilkinson
Journal: JAMA (1980)

Convulsions have not been emphasized as a possible complication of carotid endarterectomy. We describe here three patients in whom seizures with a focal component developed postoperatively. We suspect that the convulsions were secondary to a cerebral embolus arising from the operative site. An unstable preoperative neurological status is not a prerequisite for this complication. (<i>JAMA</i>244:1827-1828, 1980)
POLYCYTHEMIA.
Authors: WILLIAM ENGELBACH
Journal: JAMA (1906)

In 1892 Rendu and Widal reported the discovery of a peculiar condition characterized by the rare combination of chronic cyanosis, enlarged spleen and increased number of the erythrocytes occurring with primary tuberculosis of the spleen. In 1899<sup>1</sup>they reported two similar cases. In 1904 Turck<sup>2</sup>reported seven cases and reviewed exhaustively thirteen cases reported in the literature up to that time (Vaquez,<sup>3</sup>M. Martin and Lefas,<sup>4</sup>Cominotti,<sup>5</sup>Cabot,<sup>6</sup>2; McKeen,<sup>7</sup>Saundby and Russell<sup>8</sup>2, Rosengart,<sup>9</sup>Osler<sup>10</sup>4). In 1905 Reckzeh<sup>11</sup>reported five cases, presented some experimental results on the production of this condition on animals and reviewed the literature of twenty-nine cases previously reported. This makes in all a total of thirty-four cases so far reported. <h3>REPORT OF AUTHORS' CASE.</h3><h3>Patient.</h3> —Mrs. E. S., aged 40, housewife. Russian Jew. <h3>History.</h3> —Family history was negative. Until her thirtieth year she
Oxygen modulates the glucagon-dependent activation of the phosphoenolpyruvate carboxykinase gene in the first 277 bp of its promoter by sequences different from the CRE via a heme protein-mediated mechanism in hepatocytes Institut f�r Biochemie und Molekulare Zellbiologie, Humboldtallee 23, D-37073 G�ttingen, Germany
Journal: Hepatology (1995)

Chromium is an essential mineral that is thought to be necessary for normal glucose homeostasis. Numerous studies give evidence that chromium picolinate can modulate blood glucose and insulin resistance. The main ingredient of Tianmai Xiaoke (TMXK) Tablet is chromium picolinate. In China, TMXK Tablet is used to treat type 2 diabetes. This study investigated the effect of TMXK on glucose metabolism in diabetic rats to explore possible underlying molecular mechanisms for its action.Diabetes was induced in rats by feeding a high-fat diet and subcutaneously injection with a single dose of streptozotocin (50 mg/kg, tail vein). One week after streptozotocin-injection, model rats were divided into diabetic group, low dose of TMXK group and high dose of TMXK group. Eight normal rats were used as normal control. After 8 weeks of treatment, skeletal muscle was obtained and was analyzed using Roche NimbleGen mRNA array and quantitative polymerase chain reaction (qPCR). Fasting blood glucose, oral glucose tolerance test and homeostasis model assessment of insulin resistance (HOMA-IR) index were also measured.The authors found that the administration of TMXK Tablet can reduce the fasting blood glucose and fasting insulin level and HOMA-IR index. The authors also found that 2 223 genes from skeletal muscle of the high-dose TMXK group had significant changes in expression (1 752 increased, 471 decreased). Based on Kyoto encyclopedia of genes and genomes pathway analysis, the most three significant pathways were “insulin signaling pathway”, “glycolysis/gluconeogenesis” and “citrate cycle (TCA)”. qPCR showed that relative levels of forkhead box O3 (FoxO3), phosphoenolpyruvate carboxykinase 2 (Pck2), and protein tyrosine phosphatase 1B (Ptp1b) were significantly decreased in the high-dose TMXK group, while v-akt murine thymoma viral oncogene homolog 1 (Akt1) and insulin receptor substrate 2 (Irs2) were increased.Our data show that TMXK Tablet reduces fasting glucose level and improves insulin resistance in diabetic rats. The mechanism may be linked to the inactivation of PTP1B and PCK enzymes, or through intracellular pathways, such as the insulin signaling pathway.
A Balanced Teaching Hospital
Journal: BMJ (1963)

Psycho-analysis has provided an enormous stimulus both to thought and to the practice and teaching of medicine.Indeed, it may well be asked if, without those internists who became analysts in the 1920s and 1930s, there would ever have come into being the subject we know to-day as psychosomatic medicine.The book helps us to understand this develop- ment.It is for the specialist reader who is able critically to assess the individual articles in the light of a more comprehensive understanding of anorexia nervosa than the authors present.
Environmental Carcinogenesis: Summary of a Conference on Epidemiology at the XI International Cancer Congress1
Journal: JNCI Journal of the National Cancer Institute (1975)

Journal Article Environmental Carcinogenesis: Summary of a Conference on Epidemiology at the XI International Cancer Congress Get access JNCI: Journal of the National Cancer Institute, Volume 54, Issue 2, February 1975, Pages 303–304, https://doi.org/10.1093/jnci/54.2.303 Published: 01 February 1975
Abstract 3803: Targeting 17q23 amplicon to overcome the resistance to anti-HER2 therapy in HER2+ breast cancer
Authors: Yunhua Liu, Xiaoming He, Xiongbin Lu, Xinna Zhang
Journal: Cancer Research (2019)

Abstract Amplification of chromosome 17q23 is a frequent genomic event that occurs in ~ 11% of human breast cancers. The 17q23 amplification is enriched in HER2+ breast cancers, which is significantly correlated with poor clinical outcomes. Previous studies have identified the oncogenic phosphatase WIP1 gene in the amplicon, which functions as a master inhibitor in DNA damage response. While the possibility of any other protein-coding oncogenes in the WIP1-containing 17q23 amplicon was ruled out, our analysis of human breast cancer genomics uncovered an oncogenic microRNA gene, MIR21, in a majority of the WIP1-containing amplicons. Accordingly, the 17q23 amplification results in aberrant expression of WIP1 and miR-21, which not only promotes breast tumorigenesis, but also leads to resistance to anti-HER2 therapies. Inhibiting WIP1 and miR-21 using small molecular inhibitor against WIP1 (GSK2830371) and anti-miR-21 oligonucleotides selectively inhibits the proliferation, survival and tumorigenic potential of HER2+ breast cancer cells harboring 17q23 amplification. However, the in vivo bioavailability of the two agents in their free form is poor. To overcome the resistance of trastuzumab-based therapies in vivo, we developed pH-sensitive nanoparticles for specific co-delivery of the two agents into breast tumors. The nanoparticles can improve the encapsulation efficiency of anti-miR-21 oligonucleotides but also effectively capture carbon dioxide (CO2) into the nanoparticle to achieve the ‘nano-bomb’ effect for triggered drug release under the reduced pH in tumors. The two agents (inhibitors of miR-21 and WIP1)-laden nanoparticles can be used to efficiently kill trastuzumab-resistant HER2+ breast cancer cells, leading to a profound reduction of the tumor growth in vivo. These results demonstrate the great potential of the combined treatment of WIP1 and miR-21 inhibitors for the HER2+ breast cancers resistant to anti-HER2-based therapies. Citation Format: Yunhua Liu, Xiaoming He, Xiongbin Lu, Xinna Zhang. Targeting 17q23 amplicon to overcome the resistance to anti-HER2 therapy in HER2+ breast cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3803.
JAMA Pediatrics
Authors: Phil Fontanarosa, Annette Flanagin, Brenda Gregoline, Tracy Frey, Shannon Sparenga, Nicole Balin, Miriam Cintron, Paul Ruich, Diane Cannon, Connie Manno, Fred Marshall, Laura Copyreaders, Catherine Adamczyk, Stephanie Alden, Jan Beckmeyer, Mary Clavey, Roya Coerver-Connolly, Laura Khatiblou, Donna King, Caroline Thordsen, Wanda Assistant, Larry Bryant, Monica Mungle, Elaine Williams, Lenette Gardner-Gullens, Fanny Brown, Paul Frank, Peter Kim, Rachell Lozano, Michaela Mark, Kathryn Muskovich, Gale Saulsberry, Michael Berkwits, Michelle Kurzynski, Eric Butkus, Will English, Christopher Hastings, Craig Mccaffrey, Reuben Rios, Ronna Henry, Joshua Bird, Karen Bucher, David Song, Deputy Livingston, Thomas Cole, Marla Hall, Deanna Willis, Yolanda Davis, Joseph Thornton, Preeti Malani, Deanna Bellandi, Jim Periodical, Thomas Staff, Monica Smith, Jeffery Bonistalli Manager, Kathy Russell, Mirna Monal, Tim Melroy, Thalia Moss, Mike Harvey, Susan Henning, Mark Thornbury, Tricia Castellano, Saskia Bolore, Gretchen Linder, Brian Mccartney, David Baum, Rebecca Haas, Christine Hearne, Irma Millie, Lara Marketing, Matt Herron, Elizabeth Solaro, Geoffrey Flick, Paul Gee Managers, Rick Bell, Lindsay Dawson, Michael Mcgraw, Sara Nagy, Romando Rossini, Stacy Staff, Millette Jackson-Bates, Karen Adams-Taylor, Karl Elvin, Sue Sherrill, Brian Shields Managers, David Antos, Chris Borden, Debbie Camp, Lydia Cruz, Scott Curl, Diane Darnell, Colleen Kelly, Chris Meyer, Jaye Mize, Annemarie Neff, J Neff, Sean O'donnell, Sean Ohlson, Phil O'leary, Susan Price, Denise Steinhauser, Production Services, Kim Boler, Rhonda Brown, Timothy Burke, Daniel Degroot, Jordynn Farrar, Euwanaha Joiner-Smith, Cindy Rendlen, Ellen Yoshihara, Circulation Services, Julie Burton, Dexter Golden, Erin Hinchcliff, Noemi Rivera, Geneine Van, Someren Composition, New Media, Gail Barrett, Regina Brownlee, Amanda Camino, Brenda Chandler-Grayer, Amy Evers, Teri Hutchison, Mary Kuranda, Joshua Lampinen, Patricia Panek, La Son, Diggs Sledge, George Thomson Graphics, Joe Amft, Maria Duda, Fred Furtner, Carolyn Hall, Maria Kowalkowski, Proofreading Carol, Joy Farrell, Daniel James, Judith Literskis, Teresa Omiotek, James Madara, Bernard Hengesbaugh, Dimitri Christakis, Alain Joffe, Ron Keren, Suzanne Shuey, Peter Cummings, Howard Bauchner, Frederick Rivara, Samir Shah, Joyce Lee, Ann Arbor, Jay Berry, Cherrie Boyer, San Francisco, Maria Britto, John Campo, Aaron Carroll, Indiana Frank, Joseph Chaloupka, Mitchell Cohen, Kathleen Janz, Iowa City, Terry Klassen, Michigan Michelle, Huckaby Lewis, Aaron Milstone, Shawn Rangel, Martha Sola-Visner, Jean-Claude Carel, Shabir Madhi, Ben Marais, Frank Oberklaid, Susan Sawyer, Joan-Carles Surís
Journal: JAMA Pediatrics (2014)