tbuckley/cabot-search huggingface dataset:
Abstract 5741: Dexamethasone suppresses cytokine-induced dual oxidase 2 and VEGF-A expression in human pancreatic cancer cells in vitro and pancreatic cancer growth in xenografts
Authors: Yongzhong Wu, James H. Doroshow
Journal: Cancer Research (2018)

Abstract Chronic pancreatic inflammation is strongly associated with pancreatic cancer. We previously demonstrated that inflammatory cytokines interact to produce a DUOX2 -dependent, reactive oxygen species (ROS)-related, pro-oxidant milieu that could increase the pathologic potential of pancreatic inflammation, enhancing malignant transformation. Furthermore, we have shown that DUOXuox2 expression is upregulated in patients with chronic pancreatitis as well as pancreatic ductal adenocarcinoma (PDAC). Dexamethasone (Dex) has been reported to inhibit PDAC invasiveness, the formation of pancreatic intraepithelial neoplasia in genetically-engineered mouse models of pancreatic cancer, as well as epithelial to mesenchymal transition in PDACs, and local tumor recurrence and metastasis in vivo. Using cultured human pancreatic cancer cell lines, we found that in a dose- and time-dependent fashion Dex inhibited cytokine (IFN-γ/LPS, IL-4, and IL-17)-mediated up-regulation of DUOXuox2 and VEGF-A expression in several human pancreatic cancer cell lines, including BxPC-3, ASPC-1, and CFPAC-1. Dex pretreatment also blocked DUOX2-related DNA double strand breaks (detected as activated γH2AX) and the expression of HIF-1α in PDAC cells treated with pro-inflammatory cytokines. The effects of Dex were abolished by pre-treatment with the Dex antagonist RU-486. As expected, we did not observe anti-proliferative effects of Dex on PDAC cells in vitro. However, Dex strongly repressed DUOXuox2 mRNA and protein expression as well as the growth of xenografts initiated from BxPC-3 cells; in contrast, for the MIA-Paca line that is unresponsive to cytokines in culture, Dex produced no effect on DUOXuox2 expression and tumor growth when these cells were grown as xenografts. Examination of the human DUOXuox2 promotor in silico revealed a putative negative glucocorticoid receptor (GR) binding element. Western analysis, using nuclear extracts from pancreatic cancer cells treated with Dex, revealed that both activated glucocorticoid receptor and certain co-repressors, such as NCOR-1/2 and histone deacetylases (HDAC1, 2, and 3) exist in human pancreatic cancer cell nuclei. Our ongoing experiments are focused on understanding the molecular mechanism of Dex-mediated DUOXuox2 repression both in vitro and in vivo. In summary, these studies suggest that cytokine-related oxidant stress, generated by Duox2, could play a role in the progression of pancreatic cancer. Citation Format: Yongzhong Wu, James H. Doroshow. Dexamethasone suppresses cytokine-induced dual oxidase 2 and VEGF-A expression in human pancreatic cancer cells in vitro and pancreatic cancer growth in xenografts [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 5741.
C-REL NF-KAPPA B SUBUNIT ACTIVITY REFINES A DISTINCT GERMINAL CENTER DIFFUSE LARGE B-CELL LYMPHOMA SUBGROUP WITH FAVORABLE OUTCOME
Authors: N. Faumont, O. Taoui, D. Collares, J.-P. Jais, K. Leroy, F. Jardin, T. Molina, V. Baud, J. Feuillard
Journal: HemaSphere (2019)
It's ok to get sick in July
Authors: R. P. Perry
Journal: JAMA (1990)

"I want a real doctor, not an intern, taking care of me!" said my elderly friend as we discussed the relative merits of having her hip surgery performed at the university hospital rather than at the community hospital—this, despite the fact that she knew that I was the director of the internal medicine residency program at the same teaching hospital. This distrust of medical academia reaches its annual peak in July, when anyone living in the shadow of a teaching hospital knows that he or she will be "done in," physically or financially, by new house staff freshly arrived from medical school graduation if he or she should have the misfortune of getting sick in the summertime. While we like to think of the fear of this "July phenomenon" as a vestige of a previous era in medical education, the possibility that physician inexperience may impose additional burdens on patients
Rural Primary Care
Authors: American College of Physicians*
Journal: Annals of Internal Medicine (1995)

This overview of rural health care today shows the role that internal medicine can and should play in delivering primary care to rural populations.The American College of Physicians recommends changes to improve access to and delivery of primary care in rural areas. There are six specific recommendations. 1.Implementing universal health care coverage through a system that makes primary care equally affordable to rural populations. 2.Increasing the supply of primary care providers in rural areas by lessening specialty and geographic differentials in physician income. 3.Increasing the supply of primary care providers in rural areas by changing medical education to emphasize training enough rural physicians. 4.Decreasing professional isolation in rural areas through accessible continuing medical education and through telecommunications technology. 5.Identifying tertiary care needs at the community level and using state and federal funds to assist rural hospitals where access to care would be threatened by hospital closure. 6.Using innovative delivery systems that emphasize coordination and cooperation among providers, institutions, and communities. *This paper, authored by Janet Weiner, MPH, was developed by the Rural Advisory Group (see the Appendix for members of this group) for the 1993-1994 Health and Public Policy Committee: Gerald E. Thomson, MD, Chair; Whitney Addington, MD; Robert A. Berenson, MD; Christine K. Cassel, MD; Nancy E. Gary, MD; Sheldon Greenfield, MD; David J. Gullen, MD; Charles E. Harrison Jr., MD; L. Julian Haywood, MD; Ana Maria Lopez, MD; Ernest L. Mazzaferri, MD; Mack V. Traynor, MD; and James R. Webster Jr., MD. This paper was approved by the Board of Regents on 21 November 1993.
Subarachnoid Hemorrhage
Authors: Michael T. Lawton, G. Edward Vates
Journal: New England Journal of Medicine (2017)

Aneurysmal subarachnoid hemorrhage is diagnosed by computed tomography of the head and by CT angiography, catheter angiography, or both. Randomized trials suggest that aneurysms treatable by either open surgery or endovascular intervention are usually better treated by the latter.
Differences in Age of Smoking Initiation Between Blacks and Whites—United States
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Theatre: Sleepers
Authors: J. Allen
Journal: BMJ (2002)

Playing at theatres in Scarborough, Derby, Winchester, and Exeter throughout November and December. Information on venues and dates available from 0115 911 1471 Rating:![Graphic][1]</img> Despite years of campaigns about doctors' hours, it has taken disasters such as the Selby rail crash to make sleep deprivation big news. In the arts, sleep and the lack of it have been sources of inspiration for many works: Frankenstein came to Mary Shelley during a bout of insomnia, and Tchaikovsky's The Nutcracker , Berlioz's Symphonie Fantastique , and the recent David Lynch film Mulholland Drive all have dream sequences at their core. But … [1]: /embed/inline-graphic-1.gif
Regional enteritis of the colon. Distinctive features of the entity
Authors: W. A. Hawk
Journal: JAMA (1967)

Of approximately 1,500 cases of primary ulcerative disease of the colon seen at the Cleveland Clinic since 1950, about half may be classified as regional enteritis of the colon. Grossly, the disorder is characterized by serpiginous or longitudinal furrow ulcers or both, segmentally or diffusely arranged with areas of normal-appearing mucosa separating the ulcers. Microscopically, the inflammation is transmural. Noncaseating, sarcoid granulomas may be found but are absent in one third of the cases. Deep fissures, which may extend through the bowel wall, may be observed in 25% to 30% of cases and appear to be the basis for fistula formation. Post-colectomy ileitis occurs far more commonly in patients with regional enteritis of the colon than in patients with chronic ulcerative colitis; the incidence is about equal in patients with or without ileitis at the time of first colectomy. No increased risk of the development of carcinoma was noted.
Resuscitation
Authors: Sidney C. Wiggin, Peter Saunders, George A. Small
Journal: New England Journal of Medicine (1949)

Cardiorespiratory ArrestIN THE multitude of clinical and experimental material reported in the last two decades, cardiac arrest and respiratory arrest are usually regarded as two distinct entities. It is true that certain events result in cardiac arrest, whereas other circumstances lead to cessation of respiration; however, because these two are so closely related in pathological physiology and in therapy, thinking on the problems engendered must, in every instance, include both. Synonymous with Courville's1 phraseology, "respiro-cardiac crises," the term cardiorespiratory arrest is suggested as most appropriate and is used below in referring to this phenomenon.Cardiorespiratory arrest is one of . . .
Inconsistent Salaries
Authors: N. V. Williams
Journal: BMJ (1969)

Inconsistent SalariesSIR,-I would draw attention to the advertisements for a further two doctors for the Livingston New Town with an initial remuneration of £4,000+ (net), including five sessions in the medical assistant grade (21 December, p. xxiii, and 28 December, P. xiv).It is only fair to point out that an appre- ciable number of full-time specialists are in receipt of maximum salaries as low as £3,375, while a newly appointed consultant starting at £3,200 only approximates to £4,000 after four years, reaching his peak of £4,885 after a further five years.
Reply
Authors: B Veress, R Lofberg, L Bergman
Journal: Gut (1996)

<h3>Abstract</h3> Stress increases vulnerability to psychiatric disorders, partly by affecting brain monoamine systems, such as the locus coeruleus (LC)-norepinephrine system. During stress, LC activity is coregulated by corticotropin-releasing factor (CRF) and endogenous opioids. This study identified neural circuitry that regulates LC activity of intruder rats during the resident–intruder model of social stress. LC afferents were retrogradely labeled with Fluorogold (FG) and rats were subjected to one or five daily exposures to an aggressive resident. Sections through the nucleus paragigantocellularis (PGi) and central amygdalar nucleus (CNA), major sources of enkephalin (ENK) and CRF LC afferents, respectively, were immunocytochemically processed to detect c-fos, FG, and CRF or ENK. In response to a single exposure, intruder rats assumed defeat with a relatively short latency (SL). LC neurons, PGI-ENK LC afferents, and CNA-CRF LC afferents were activated in these rats as indicated by increased c-fos expression. With repeated stress, rats exhibited either a SL or long latency (LL) to defeat and these strategies were associated with distinct patterns of neuronal activation. In SL rats, LC neurons were activated, as were CNA-CRF LC afferents but not PGI-ENK LC afferents. LL rats had an opposite pattern, maintaining activation of PGi-ENK LC afferents but not CNA-CRF LC afferents or LC neurons. Together, these results indicate that the establishment of different coping strategies to social stress is associated with changes in the circuitry that regulates activity of the brain norepinephrine system. This may underlie differential vulnerability to the consequences of social stress that characterize these different coping strategies.
Fourteenth International Cancer Congress of the International Union Against Cancer
Journal: JNCI Journal of the National Cancer Institute (1986)

Fourteenth International Cancer Congress of the International Union Against Cancer Get access JNCI: Journal of the National Cancer Institute, Volume 76, Issue 4, April 1986, Page 780, https://doi.org/10.1093/jnci/76.4.780 Published: 01 April 1986
Hirsutism, obesity, and phenothiazine therapy
Authors: R. G. Wieland
Journal: JAMA (1979)

<h3>To the Editor.—</h3> The report of Phillips et al (241:920, 1979) suggested an association of hirsutism with long-term phenothiazine therapy. The authors mentioned that testosterone levels were either normal or slightly below normal limits, although no numbers were given. In addition, no indication of levels of sex steroid binding globulin or free testosterone is available in the article. The figures showed the patient to be clearly obese. Obesity has a well-known effect on decreasing sex steroid binding globulin, thus increasing free<sup>1,2</sup>but not necessarily total testosterone levels. It is clear now that this effect is reversible with weight loss produced by either intestinal bypass<sup>3</sup>or dietary techniques<sup>4</sup>; thus, obesity would seem the more noteworthy explanation for the patient's hirsutism.
Accidental intubation of the pyriform sinus. A complication of "roadside" resuscitation
Authors: J. L. Stauffer
Journal: JAMA (1977)

PERFORATION of the hypopharynx during endotracheal intubation is most likely to occur in emergency settings such as cardiopulmonary resuscitation, but it may also occur in more controlled situations. The injury has been related to the urgency of the intubation and to the inexperience of the person performing the intubation.<sup>1</sup> The esophagus is the most commonly reported site of perforation, and barotrauma and abscess formation the most likely complications. While signs of barotrauma become evident soon after perforation, neck abscess does not become apparent for several days or weeks. <h3>Report of a Case</h3> A 58-year-old woman was brought to the emergency room by ambulance with apparent cardiorespiratory arrest. She was well 3 1/2 hours prior to admission. Shortly thereafter, she was found on the floor of a closed garage with a car engine running. Resuscitative measures were instituted by trained emergency medical technician personnel of a city ambulance crew. The
Potent Anti-Myeloma Activity Of The Novel Bromodomain Inhibitors I-BET151 and I-BET762
Authors: Aristeidis Chaidos, Valentina Caputo, Ilaria Marigo, Binbin Liu, Suhail Chaudhry, Katerina Goudevenou, Antonia Rotolo, David F Tough, Nicholas N Smithers, Anna K Bassil, Trevor D Chapman, Nicola R Harker, Olena Barbash, Peter Tummino, Niam Al-Mahdi, Andrea C Haynes, Leanne Cutler, BaoChau Le, Amin Rahemtulla, Irene Roberts, Maurits Kleijnen, Jason Witherington, Nigel J Parr, Rab K Prinjha, Anastasios Karadimitris
Journal: Blood (2013)
Antibody to Endotoxin in the Treatment of Gram-negative Sepsis
Authors: William R. McCabe
Journal: JAMA (1992)

<h3>To the Editor.</h3> —The suggestion that the E5 monoclonal antibody will be useful in reducing fatalities in gram-negative sepsis based on the article by Greenman et al<sup>1</sup>and the accompanying editorial<sup>2</sup>is less well supported by the data than is implied. The only significant reduction in fatality rates occurred in a single subset (those with gram-negative infections without shock) out of the several subsets examined. Of the subsets examined, this subset is least likely to have serious gram-negative bacillary infections. If clinical effectiveness of antibodies to endotoxin is to be critically assessed, those patients with known endotoxemia (ie, proven gram-negative bacteremia) provide the most valid indicator of effectiveness. Those patients with gram-negative infections severe enough to produce shock provide the second most valid indicator. No effect was demonstrated in either of these subsets. Past experience indicates that the enrollment criteria used in the study by Greenman et al
Quicksilver Cholecystitis
Authors: Douglas Zippel, Stefan Urbanski, Francis Sutherland
Journal: Annals of Internal Medicine (2006)

Letters20 June 2006Quicksilver CholecystitisDouglas Zippel, MD, Stefan Urbanski, MD, and Francis Sutherland, MDDouglas Zippel, MDFrom Tom Baker Cancer Centre, Calgary, Alberta T4N 4N2, Canada.Search for more papers by this author, Stefan Urbanski, MDFrom Tom Baker Cancer Centre, Calgary, Alberta T4N 4N2, Canada.Search for more papers by this author, and Francis Sutherland, MDFrom Tom Baker Cancer Centre, Calgary, Alberta T4N 4N2, Canada.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-144-12-200606200-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Background: Mercury is a highly toxic heavy metal that may cause accidental poisoning through industrial and environmental exposure. In 1923, Umber (1) was the first to report the rare occurrence of deliberate injection of elemental mercury. In this case, a young woman attempted suicide by self-injecting the substance, which caused diffuse abdominal pain, renal insufficiency, and pulmonary embolization of mercury particles. Since then, there have been approximately 20 sporadic case reports of attempted suicide by parenteral injection of elemental mercury (2). When injected intravenously, mercury usually becomes trapped in the pulmonary capillary bed; however, mercury can pass to the systemic ...References1. Umber F. Quecksilber-embolien der lebendum lunge durch intravenose injektion von metollischen quecksilber. Medizinische Klinik (Munich). 1923;19:35. Google Scholar2. Givica-Perez A, Santana-Montesdeoca JM, Diaz-Sanchez M, Martinez-Lagares FJ, Castaneda WR. Deliberate, repeated self-administration of metallic mercury injection: case report and review of the literature. Eur Radiol. 2001;11:1351-4. [PMID: 11519542] CrossrefMedlineGoogle Scholar3. Sanowski RA, Arbaje-Ramirez S. Acute cholecystitis secondary to unusual gallstones. Am J Gastroenterol. 1979;71:193-5. [PMID: 433903] MedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Tom Baker Cancer Centre, Calgary, Alberta T4N 4N2, Canada.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 20 June 2006Volume 144, Issue 12Page: 941KeywordsCholecystectomyGallbladderGallbladder cancerLiverResearch laboratoriesSaltsSuicideSurgeryToxicityUrine ePublished: 20 June 2006 Issue Published: 20 June 2006 CopyrightCopyright © 2006 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
JAMA Peer Reviewers in 2005
Authors: None Not Available
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Emergency Measles Control Activities—Darfur, Sudan, 2004
Journal: JAMA (2004)

The Darfur region of Sudan, composed of three states with a population of approximately six million, has experienced civil conflict during the previous year, resulting in the internal displacement of approximately one million residents and an exodus of an estimated 170,000 persons to neighboring Chad. The conflict has left a vulnerable population with limited access to food, health care, and other basic necessities. In addition, measles vaccination coverage has been adversely affected; in 2003, coverage was reported to be 46%, 57%, and 77% in North, West, and South Darfur, respectively. This report describes measles-control activities in Darfur region conducted by the Federal Ministry of Health (FMOH) in Sudan in collaboration with the United Nations and nongovernmental organizations (NGOs) during March-August 2004. Ongoing measles transmission in camps for internally displaced persons (IDPs) and neighboring communities in Darfur led to a regionwide measles vaccination campaign targeting all children aged 9 months-15 years, resulting in a reduction in reported measles cases. Once security is improved, ongoing efforts to increase measles vaccine coverage will be required to eliminate persistent susceptibility to measles in the Darfur population.
Food Allergy
Authors: Hugh A> Sampson
Journal: JAMA (1987)

FOOD allergy is widely perceived by the public as a major health problem.<sup>1</sup>Although the true prevalence of food allergy is unknown, it is probably much less common than thought. Its prevalence among children has been variously estimated from 0.3% to 7.5%,<sup>2</sup>and it is believed that the incidence decreases with age. Acute allergic reactions to foods that are clearly IgE mediated can, however, develop in adults who previously tolerated foods with impunity.<sup>3,4</sup>Clinically, food-induced reactions of the immediate-hypersensitivity type are well documented and include urticaria, angioedema, and anaphylaxis. Reactions to foods mediated through antigen-antibody—complex and delayed-hypersensitivity mechanisms remain to be implicated, except in gluten-induced enteropathy and severe milk- and soyinduced gastroenteropathies in infants and children.<sup>5</sup> <h3>CLINICAL FEATURES</h3> Immunologically mediated reactions to foods are expressed clinically by a diversity of signs and symptoms, ranging from abdominal pain to generalized anaphylaxis. These clinical expressions of food allergy