tbuckley/cabot-search huggingface dataset:
Famciclovir for genital herpes
Authors: B. D. Goldman
Journal: JAMA (1997)

<h3>To the Editor.</h3> —I read with great interest the article on the use of famciclovir in recurrent genital herpes by Dr Sacks and colleagues.<sup>1</sup>Interestingly, no mention was made on the number of clinical episodes (the development of vesicular and ulcerative lesions) of genital herpes aborted by famciclovir, although the incidence of aborted clinical episodes was mentioned as a parameter in the "Methods" section. This well-designed study<sup>1</sup>should have been able to detect any effect, since treatment was patient initiated and patients were selected to have prodomal symptoms. Abortive viral shedding was found. However, it is not clear whether the ability of famciclovir to abort clinical episodes was studied and found to be insignificant vs placebo or simply was not studied.
Archives of Neurology, Chicago
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 1730: <i>DACH1</i> gene deletion extends portraits of human prostate cancer
Authors: Xuanmao Jiao, Gabriele Di Sante, Zhiping Li, Agnese Di Rocco, Min Wang, Adam Ertel, Peter A. McCue, Andrew P. South, Carlos Cordon-Cardo, Matthew P. Stokes, Marco Marra, Steven J. Jones, Andrew Kossenkov, Richard G. Pestell
Journal: Cancer Research (2019)

Abstract Purpose of the study: This study was conducted to define the role of Dachshund in prostate cancer, through assessing human prostate cancer samples and through genetic deletion in the mouse. Prostate cancer (PCa), the second leading cause of death in American men, is a genetically heterogeneous disease, likely representing distinct genetic drivers, with terminal events caused primarily by metastasis. Substratification of PCa into genetic subtypes, forms the basis of rational therapy for PCa. A better molecular understanding of the disease is necessary in order to develop novel targeted therapies of metastatic PCa. Known genetic drivers to tumor initiation include PTEN and NKX3.1 deletions, rearrangements of the TMPRSS2 gene to the oncogenic ETS transcription factor, ERG, and genetic predisposing factors include germline DNA-repair gene mutations. The DACH1 gene, initially cloned as an inhibitor of Elipse, the hyperactive epidermal growth factor (EGFR) in Drosophila, was found to be reduced in abundance in several malignancies including breast and prostate cancer. Results: In order to determine whether the DACH1 gene is deleted or mutated in prostate cancer we interrogated the genomic sequencing analysis of over 490 patients from 5 population cohorts. Homozygous deletion of DACH1 was identified in 18% (N=61), 11% (N=136), 10% (N=492), 7% (N=103) and 3% (N=150) of prostate cancer in 5 distinct cohorts. The prevalence of DACH1 gene deep deletions was higher in the metastasis than in the primary tumors. The Transgenic Adenocarcinoma Mouse Prostate (TRAMP) transgenic, Dach1fl/fl, and Probasin-Cre, ROSA26mT/mG transgenic mice were used to generate a prostate epithelial cell specific Dach1 gene knockout mouse (Probasin-Cre-Dach1fl/fl ROSA26mT/mG-TRAMP) lines. Prostate specific deletion of the murine Dach1 gene enhanced progression of prostatic intraepithelial neoplasia (PIN), associated with increased prostate epithelial cell proliferation, epithelial mesenchymal transition (EMT), DNA damage and inflammation. Conclusions: DACH1 gene deletion may define a distinct subclass of prostate cancer that may benefit from PARP inhibitors, and platinum-based chemotherapy. Citation Format: Xuanmao Jiao, Gabriele Di Sante, Zhiping Li, Agnese Di Rocco, Min Wang, Adam Ertel, Peter A. McCue, Andrew P. South, Carlos Cordon-Cardo, Matthew P. Stokes, Marco Marra, Steven J. Jones, Andrew Kossenkov, Richard G. Pestell. DACH1 gene deletion extends portraits of human prostate cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1730.
THE ARMY MEDICAL SERVICE.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medicating Distress
Authors: Donovan T. Maust, Helen C. Kales
Journal: JAMA Internal Medicine (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Mammography before age 50 years?
Authors: J. C. Bailar
Journal: JAMA (1988)

Considerable agreement exists about mammography. Virtually all experts conclude that an asymptomatic woman who is at least 50 years old will benefit from regular breast cancer screening by a combination of mammography and careful physical examination. Most agree, also, that women who have genuine signs or symptoms suggestive of a malignant lesion are candidates for mammography, regardless of their age, when it is clear that the examination is needed to determine the next steps in the diagnostic studies. This use of mammography, as an aid to diagnosis rather than for screening, will generally be appropriate when the examination will assist in determining whether, where, and how to perform a biopsy. While agreement exists for this population of women, for those younger than 40 years of age, the arguments for a "baseline" examination are incomplete and unconvincing. No good evidence exists showing that the availability of baseline films affects the later
Dear Doctor... Regarding Calcium Channel Blockers
Authors: Peter Lurie
Journal: JAMA (1996)

<h3>To the Editor.</h3> —In response to the article by Dr Psaty and colleagues,<sup>1</sup>thousands of physicians across the country received a "Dear Doctor" letter from an internationally recognized expert in the treatment of hypertension. The letter's author offered a number of criticisms of the study and suggested that the results do not apply to nifedipine, one of the calcium channel blockers (CCBs) discussed in the study. The letter, which was printed on the author's university stationery and postmarked on the day the article was published, did not acknowledge any drug company sponsorship. In a conversation with the author of the letter on September 11, 1995, he informed one of us (P.L.) that the letter and its distribution had been funded by Bayer Corporation, one of the two US makers of nifedipine. He stated that he had been contacted by a public relations company representing Bayer and had been asked
PENICILLIN SENSITIVITY
Authors: F E Palomeque, J Fulton, V J Derbes
Journal: JAMA (1964)

The results obtained in this study indicate that there are various patterns of hypersensitivity to penicillin. In order to detect these variations it is suggested that two antigens, penicillin and penicilloyl-polylysine, be employed to test for both serum and skin sensitivity. Absolutely accurate predictions cannot be made from these tests, but it is felt that their use will minimize untoward reactions of the anaphylactic type in patients thus screened for penicillin allergy.
Epidemiologic Study of Vinyl Chloride Workers: Mortality through December 31, 1972
Authors: W. Clark Cooper
Journal: Environmental Health Perspectives (1981)

A population of 10,173 men, employed in 37 plants, was identified as having worked for at least one year in jobs involving probable exposure to vinyl chloride monomer (VCM) prior to January 1, 1973. Of the 9677 men whose vital status was determined, 707 were known to have died. For 699, death certificates were obtained. The standardized mortality ratio (SMR) for all causes was 89, that for all malignancies was 104. The only type of malignancy found in significant excess was in the category of malignant neoplasms of the brain and other parts of the nervous system; 12 deaths occurred where 5.9 were expected, for an adjusted SMR of 203. There were slight but inconclusive upward trends in all malignancies, and for malignancies of the respiratory tract, digestive tract, and central nervous system associated with reported levels of maximum exposure to VCM. When groups in whom less than 20 years had elapsed from the first exposure were compared with those with 20 or more elapsed years, and 25 or more elapsed years, no significantly different SMR's were detected for major primary sites of malignancy. Plans for an updated study of mortality, to include deaths in the period 1973-1979 are briefly discussed.
NORWAY
Journal: JAMA (1952)

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Thoracic Surgery
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Urinary lactic dehydrogenase in genitourinary tract diseases
Authors: H. Grabstald
Journal: JAMA (1969)

Enzyme studies of urinary lactic dehydrogenase (LDH) have been carried out in a total of 263 patients with various diseases of the genitourinary tract seen at this institution. Almost half had bladder tumors, but patients with other diseases, both benign and malignant, were also included in the study. Elevation of urinary LDH enzyme levels is noted after catheterization and instrumentation. Elevation seems more related to the presence of pyuria, hematuria, and bacteriuria than to the presence of a specific, proved tumor. Only rarely does a patient with normal results of urinalysis have elevated LDH levels. Urinary LDH levels and results of cytologic studies of urinary sediment show a poor correlation. We have concluded that urinary LDH determinations are not useful as a routine diagnostic procedure in the study and follow-up of patients with malignant diseases of the genitourinary tract.
On Opium, as a Remedy for the Effects of Uterine Haemorrhage
Authors: T. Dorrington
Journal: BMJ (1844)

THE EFFECTS fallen to my lot to see many cases of Uterine Himor- OF UTERINE HMEMORRHAGE.rhage of all degrees of severity, and I have generally adopted this plan of treatment.I say generally,because I have occasionally adopted the stimulating Surgeon to the Manchester and Salford Lying-in plhn of treatment, in order to Ascertain its comparative Hospital.value; but so satisfied am I that the plan of Dr.H aDuncan Stewart is preferable to all other modes of In the year 1816, Dr. Duncan Stewart, Physician managing these cases, that I am anxious to add my Accoucheur to the Westminster General Dispensary, testimiony in its favour.and a Lecturer on Midwifery, in London, published a I may remark in limine, that the object of this com.short but excellent treatise on the management of munication is not to advocate the practice to the Uterine Hiemorrhage, in which he advocated the use of exclusion of the ordinary modes of suppressing Uterine large doses of Opium in this affection, and illustrated Hsemorrahage, but rather to bring it forward as a his views by some very striking cases.The practice val,sable means of comnbating the efects of hlmorrlhage he recommended has, hlowever, metwith less attention otn t/e system-effects which either lead to de%h in a from the profession than it deserved, although it has very short space of tiume, or leave the patient in a received the sanction of two great names in this state of fearful exhaustion, from which she has a pro-
Metastatic thyroid carcinoma
Authors: W. B. Shelley
Journal: JAMA (1973)

During the past 35 years, a patient has had four distinct examples of asymptomatic, gross, metastatic thyroid adenocarcinoma, each discovered on a relatively fortuitous basis. He was seeking medical attention for unrelated matters, viz, for an inguinal hernia, after automobile accident, during a routine surgical follow-up examination, and for dry skin, when the metastases in the lymph nodes, lung, axillary skin, and scalp, respectively, were noted and surgically removed. The benignity of these metastatic cancers reflects their location in noncritical sites as well as their extremely slow growth rate.
Technology
Authors: Benjamin G. Druss
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Malingering.
Authors: F. W. Dennis
Journal: JAMA (1899)

Unionville, N. Y., Dec. 29, 1898. <h3>To the Editor:</h3> —On Aug. 20, 1898, theJournalconsiderately published a letter from me, on "Malingering," that recited a case in which suit for malpractice had been instituted. It seemed to me that the matter was of general interest to the profession then, as the outcome is now, so an outline of the progress of the case is here given, in order of time: The plaintiff's attorneys wrote me asking for a settlement by a certain time. I answered that there was nothing to settle. They then served first papers, without complaint, in a suit for $5000 damages, and I at once employed a careful and experienced attorney, and instructed him to push the suit to an issue without any delay whatever. Complaint asked for and received in two or three weeks. It was as follows: Damages demanded for "careless, negligent, wrongful and
Obituary Listing
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 18162: Children First Study II: How an Educational Program in Cardiovascular Prevention at Public Schools Can Improve Parents’ Cardiovascular Risk
Authors: Cristiano J Pinto, Silvia M Oyama, Maria M Rodrigues, Taciana Davanço, Daniela Calderaro, Bruno Caramelli, Luciana S Fornari
Journal: Circulation (2015)

Objective: To evaluate whether a multidisciplinary educational program in cardiovascular prevention for children could improve the Framingham cardiovascular risk (FCR) of their parents after one year, in public schools in Brazil. Methods: We performed a prospective community-based study in Brazil during 2013 that randomized students aged 6 to 10 years old to two different approaches to receiving healthy lifestyle information. The control group received written educational material (EM) for their parents about healthy lifestyle. The intervention group received the same EM for parents and children were exposed to a weekly educational program in cardiovascular prevention with a multidisciplinary health team. At onset and end of the study we collected data from parents and children (clinical information, weigh, height, arterial blood pressure and laboratorial tests). Results: We studied 265 children and 419 parents. Analyzing the parents’ FCR we found that 9% of the control group and 13% of the intervention group had more than a 10% year risk of cardiovascular heart disease over the next 10 years (intermediate/high FCR). After the children educational program during one year in public schools, the intervention group had a reduction of 30% in the intermediate/high FCR group compared with a 0% reduction in the control group (p&lt;0.008). The risk factor that mainly contributed for FCR reduction in the intervention group was blood pressure, with a reduction in SBP of 122.45 to 118.46 mmHg (p&lt;0.001), and DBP of 84.59 to 80.03 mmHg (p&lt;0.001), with no reduction in the control group (117.47 to 118.01 mmHg for SBP, p=0.7241, and 76.60 to 77.45 mmHg for DBP, p=0.1387). Conclusion: An educational program for cardiovascular prevention directed to school age children in public schools can reduce the FCR risk of their parents, especially in the intermediate/high risk categories, like we observed in private schools.
Diabetes Mellitus
Authors: Samuel B. Beaser
Journal: New England Journal of Medicine (1956)

IN this report the following aspects of diabetes mellitus are considered: biochemistry and physiology; insulin and its metabolism; endocrine effects; pathology and pathogenesis; diagnosis; clinical diabetes; therapy, insulin and hypoglycemic sulfonamides; pregnancy and diabetes; and complications.Carbohydrate MetabolismExperimental diabetes has continued to shed light on the biochemical defects of human diabetes. Several sites have been suggested for these defects.† It is not always easy to distinguish between the various possibilities and to decide which defects are primary and which secondary effects of the diabetic state.In a previous review,3 evidence for a diabetic defect in transfer of glucose across . . .