tbuckley/cabot-search huggingface dataset:
Nineteenth Annual Report of the Alumni Association, etc., of the Philadelphia College of Pharmacy, 1883.—
Journal: JAMA (1883)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nephrology
Authors: L. B. Berman
Journal: JAMA (1981)

<h3>Dialysis: Economics</h3> The liveliest ferments in nephrology today concern various aspects of dialysis. Chief among these are economic questions.<sup>1,2</sup>Long-term hemodialysis has been a ward of the federal government for the last eight of its 20 years and has been widely used in models to predict the shape of socialized medicine. While the present state of affairs does not inspire confidence in federal management of largescale medical enterprises, not all of the problems are of Washington's making, eg, the astonishing rate of growth of the dialysis population. Consider the following tables (the numbers are the author's choices from several possible estimates). Such enormous expenditures for so few people have disturbed a number of observers and have led to repeated calls for cheaper methods of treatment, chiefly one form or another of home dialysis. Assuming that 50% of a rapidly increasing dialysis population may be suited to dialysis at home,
Transcriptional control of viral gene therapy by cisplatin
Authors: James O. Park, Carlos A. Lopez, Vinay K. Gupta, Charles K. Brown, Helena J. Mauceri, Thomas E. Darga, Abdullah Manan, Samuel Hellman, Mitchell C. Posner, Donald W. Kufe, Ralph R. Weichselbaum
Journal: Journal of Clinical Investigation (2002)

Ionizing radiation (IR) and radical oxygen intermediates (ROIs) activate the early growth response-1 (Egr1) promoter through specific cis-acting sequences termed CArG elements. Ad.Egr.TNF.11D, a replication-deficient adenoviral vector containing CArG elements cloned upstream of the cDNA for human recombinant TNF-α was used to treat human esophageal adenocarcinoma and rat colon adenocarcinoma cells in culture and as xenografts in athymic nude mice. Cisplatin, a commonly used chemotherapeutic agent, causes tumor cell death by producing DNA damage and generating ROIs. The present studies demonstrate induction of TNF-α production in tumor cells and xenografts treated with the combination of Ad.Egr.TNF.11D and cisplatin. The results show that the Egr1 promoter is induced by cisplatin and that this induction is mediated in part through the CArG elements. These studies also demonstrate an enhanced antitumor response without an increase in toxicity following treatment with Ad.Egr.TNF.11D and cisplatin, compared with either agent alone. Chemo-inducible cancer gene therapy thus provides a means to control transgene expression while enhancing the effectiveness of commonly used chemotherapeutic agents.
Publication of Report on Tobacco Control Investment by States
Journal: JAMA (2001)

ment in Tobacco Control: State Highlights, 2001. 1 The publication presents information for all 50 states and the District of Columbia on the prevalence of tobacco use, the health impact and costs associated with tobacco use, the amount of funding for tobacco control, and excise taxes on tobacco.States can use the information in the report in developing tobacco control programs.Investment in Tobacco Control is the third state highlights report released by CDC's Office on Smoking and Health, National Center for Chronic Disease Prevention and Health Promotion, and is the first to provide a compilation of states' investments in tobacco control.The report presents an analysis of investments in tobacco control, places these investments in the context of health and economic consequences of tobacco use specific to the state, and compares current investments with the funding ranges recommended in CDC's Best Practices for Comprehensive Tobacco Control Programs. 2 The report shows that in fiscal year 2001, 45 states are investing $883.2 million in tobacco prevention and control programs, including 36 states investing $654.9 million from state settlements with the tobacco industry; eight states appropriating $218.4 million from tobacco excise tax revenues; and nine states appropriating $9.9 million from their general revenues.
Colon tumors and colonoscopy
Authors: S. Misra, M. Dwivedi
Journal: Endoscopy (2009)

DDW 2009, held in Chicago, was replete with new data on advances in colonic instrumentation, the impact of newer imaging modalities such as magnification endoscopy and autofluorescence imaging on the management of colonic tumors, and the use of self-expanding metal stents (SEMSs) in the management of stricturing colonic neoplasia. A significant volume of presented data addressed the use of endoscopic submucosal dissection (ESD) and endoscopic mucosal resection (EMR) in treating depressed and laterally spreading colonic tumors.
Antitumor Strategies Based on Enhancing —and Blocking—Effects of Interleukin-2
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Thanksgiving Day
Authors: Hugh H. Hussey
Journal: JAMA (1973)

It is not surprising that Thanksgiving Day originated with the Pilgrims who emigrated from Britain for religious reasons. They brought Puritanism in one of its purest forms to America. They proposed to worship God as they imagined the early Christians did, and, although they searched the New Testament with utmost ardor, they were not unmindful of the Old. Appropriate to their and our times of troubles are the Psalms. <h3>PSALM 95.</h3> O COME, let us sing unto the LORD: let us make a joyful noise to the rock of our salvation. Let us come before his presence with thanksgiving, and make a joyful noise unto him with psalms. For the LORD is a great God, and a great King above all gods. In his hand are the deep places of the earth: the strength of the hills is his also. The sea is his, and he
PROCEEDINGS OF THE FIRST MEETING OF THE CENTRAL SOCIETY FOR CLINICAL RESEARCH HELD IN CHICAGO, ILL., NOVEMBER 23, 1928
Journal: Journal of Clinical Investigation (1929)

Movement of blood into the thorax is favored by the increased negativity of intrapleural pressure on inspiration.Accordingly venous pressure in the acces- sible peripheral veins of the forearm falls on inspiration.With the initiation of expiration and the coincident fall of intrapleural negative pressure, peripheral venous pressure increases.Under ordinary circuimstances in the normal individual
Chronic HBV infection: assessment and management of disease in a young adult clinic
Authors: C. Patel, U. S. Gill, F. Glyn, S. Naik, G. R. Foster, P. T. F. Kennedy
Journal: Gut (2011)

<h3>Introduction</h3> Chronic hepatitis B (CHB) is a dynamic disease process with patients moving between disease phases over time. The majority of young adults infected with CHB are exposed to the virus perinatally or in the early years of life. Despite this, the extent of liver disease in this group remains ill-defined, as are the indications and timing of treatment. The aim of this study was to elucidate the extent of liver disease in a cohort of patients identified for a newly established young adult viral hepatitis clinic. <h3>Methods</h3> Only young adults who underwent liver biopsy for the assessment of CHB were included in the study. 70 patients (male=49), median age 26 (range 16–30), were examined. Data on ethnicity, BMI and eAg status were collated. Longitudinal data including viral load and ALT were recorded for 6–18 months prior to each patient undergoing liver biopsy. Normal ALT levels in the group were defined as;&lt;30 IU/l males, &lt;19 IU/l females in accordance with the Prati criteria. These clinical parameters were evaluated for their utility in predicting fibrosis stage (FS); fibrosis score 0–6, in accordance with the modified Ishak score. Disease severity in the young adult group, defined as FS, was compared with that reported in 51 consecutive CHB patients (&gt;30 years), (male=45), median age 43 (range 32–71), undergoing liver biopsy for disease assessment. <h3>Results</h3> 38/70 of the young adults were eAg positive; median ALT over the course of follow-up was 61 (range 11–1050). 14 were Caucasian, 38 Asian and 18 Afro-Caribbean. Median BMI was 22.7 (range 17.9–35.6). By univariate analysis male gender and eAg positive disease were significant in predicting more marked disease with a higher FS (p≥0.05), but abnormal ALT and non-Caucasians in particular demonstrated marked significance (p=0.0002 and p=0.001 respectively). When evaluating the level of liver disease in young adults compared with that found in the 51 older CHB patients, there was no statistical difference between the FS reported in the two groups, presence of fibrosis (p=0.93); presence of moderate to severe fibrosis (p=0.6), demonstrating a trend towards higher FS with older age. However, normal ALT over the course of follow-up in the young adult group, was significantly associated with no fibrosis (p=.001). <h3>Conclusion</h3> These data highlight the importance of formal disease assessment in this age group, as comparable levels of liver fibrosis are present in young adults as in older patients. However, closer scrutiny with assessment of ALT according to Prati criteria may identify patients with milder disease. This study emphasises the advantages of a young adult clinic in providing greater focus on CHB in this age group, enabling the early and timely intervention with therapeutic options where indicated.
Cancer patient attitudes and preferences towards smoking status assessment.
Authors: Lawson Eng, Sophia Yijia Liu, Qihuang Zhang, Delaram Farzanfar, Robin Milne, Sabrina Yeung, M Catherine Brown, Doris Howell, Wei Xu, David Paul Goldstein, Jennifer M. Jones, Peter Selby, William K. Evans, Meredith Elana Giuliani, Geoffrey Liu
Journal: Journal of Clinical Oncology (2018)

110 Background: Continued smoking after a cancer diagnosis is associated with poorer outcomes. As smoking cessation is an important part of cancer care, understanding pt attitudes towards smoking status assessment will help with integrating smoking cessation programs into survivorship care. Methods: Cancer pts were surveyed on their smoking history, assessment rates and attitudes/preferences towards smoking status assessment. Multivariate logistic regression models assessed for factors associated with screening preferences. Results: Among 501 pts, 115 smoked at diagnosis, 60% quit after; 53% had a tobacco related (lung/head and neck) cancer (TRC); 40% reported that their smoking status was assessed only on their first clinic visit, while 32% were assessed at a few visits and 12% all visits. Most felt smoking status should be assessed at the first visit (95%), while half (58%) felt it should be assessed each visit. Most felt comfortable with being assessed (96%), felt it was important for clinicians to be aware of smoking status (98%) and that smoking cessation discussions should occur at the first visit (87%). Most preferred being assessed by their oncologist (88%); less than half preferred being asked by another healthcare provider (44%), on paper (29%) or e-surveys (32%). Compared to ex/never smokers, current smokers were assessed more often at every/most visits (36% vs 20% P= 0.001) and were less comfortable with being assessed (88% vs 98% P&lt; 0.001). Among current smokers, lung cancer pts were more agreeable (58%) to being assessed each visit compared to head/neck (aOR 2.48 95% CI [0.9-6.5] P= 0.06) and non TRCs (aOR 2.63 [1.0-6.8] P= 0.05). Among all, pts who are older (aOR 1.03 [1.0-1.1]), curative (aOR 1.92 [1.1-3.2]) and smoked less (aOR 0.98 per pkyr [0.97-0.99]) were more agreeable to assessment at each visit. Most pts also felt oncologists should screen for second hand smoke exposure (92%), felt its assessment was important (93%) and should help others who smoke to quit (68%). Conclusions: Most cancer pts felt that assessment of smoking status was important, were comfortable being assessed and preferred being assessed directly by their oncologist. Routine screening of those currently smoking is recommended to help with cessation.
Author Correction: Postzygotic inactivating mutations of RHOA cause a mosaic neuroectodermal syndrome
Authors: Pierre Vabres, Arthur Sorlin, Stanislav S. Kholmanskikh, Bénédicte Demeer, Judith St-Onge, Yannis Duffourd, Paul Kuentz, Jean-Benoît Courcet, Virginie Carmignac, Philippine Garret, Didier Bessis, Odile Boute, Alain Bron, Guillaume Captier, Esther Carmi, Bernard Devauchelle, David Geneviève, Catherine Gondry-Jouet, Laurent Guibaud, Arnaud Lafon, Michèle Mathieu-Dramard, Julien Thevenon, William B. Dobyns, Geneviève Bernard, Satyamaanasa Polubothu, Francesca Faravelli, Veronica A. Kinsler, Christel Thauvin, Laurence Faivre, M. Elizabeth Ross, Jean-Baptiste Rivière
Journal: Nature Genetics (2020)
Miscellany
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
FROM OTHER PAGES
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Queries and Minor Notes.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Alcoholism in women
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Experimental Approaches for Exposure to Sized Glass Fibers
Authors: David M. Bernstein, Robert T. Drew, Marvin Kuschner
Journal: Environmental Health Perspectives (1980)

A number of studies have shown that glass fibers induce both malignant mesothelioma and fibrosis in rats and that these reactions may be primarily a function of the physical properties of the fiber. However, these studies were carried out with fibers having broad size distributions and used methods of administration which bear little resemblance to the way man is exposed. To better characterize the health effects of glass fibers, techniques have been developed to expose rats to glass fibers of defined sizes by intratracheal instillation of aqueous suspensions and by "nose only" inhalation exposure, and to determine the deposition, translocation, and ultimate fate of these fibers in the rat. The fibers have known size distributions with geometric mean diameters of 1.5 micrometers (sigma g = 1.1) and lengths of either 5 micrometers (sigma g = 1.49) or 60 micrometers (sigma g = 3.76). The fibers have been activated with neutron irradiation. Of the several resulting radionuclides, 65Zn appeared to be the most suitable for long-term clearance studies by use of in vivo whole body radioassay techniques. A fluidized bed aerosol generator has been developed to expose rats by "nose only" inhalation to approximately 500 fibers/cm3. The generator and exposure system permits reuse of fibers which pass through the exposure chamber and produces no significant alteration of the fiber size distribution. Rats were exposed by intratracheal instillations to 20 mg of the longer fibers and to equal numbers (2 mg) and equal mass (20 mg) of the shorter fibers. Through approximately 19 weeks little difference was observed in the whole rat clearance rate of long versus short fibers in the initial exposure group. Histopathology, however, showed differences at this time with the short fibers apparently successfully phagocytized by alveolar macrophages and cleared to the lymph nodes, while the long fibers were not.
Diazepam
Authors: William L. Winters
Journal: JAMA (1968)

Diazepam was administered intravenously in doses of 10 to 40 mg to 18 consecutive patients who underwent 21 elective, direct-current countershock procedures for ventricular or supraventricular arrhythmias. Hypnosis lasting 15 to 30 minutes with complete amnesia for the event was induced on 20 occasions. One patient remained semiconscious and did recall three shocks up to 400 w/sec. No significant changes in heart rate, blood pressure, or respiratory rate were noted following administration of diazepam. The drug is safe, and it has enhanced the simplicity of the entire procedure.
Residents Honored for Community Service
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal