tbuckley/cabot-search huggingface dataset:
Abstract SY25-02: Widespread germline-somatic regulatory differences in renal cell carcinoma prioritize risk mechanisms
Authors: Alexander Gusev, Sandor Spisak, Forough Abbasi, Andre Fay, Hallie Carol, Ji-Heui Seo, Toni Choueiri, Kate Lawrenson, Matthew Freedman
Journal: Cancer Research (2019)

Abstract Determining the function of non-coding regulatory variants in cancer remains a key challenge. We investigated genetic (germline and somatic) determinants of regulatory mechanisms in renal cell carcinoma (RCC) using H3K27ac ChIP-seq data in 10 matched tumor/normal samples and RNA-seq data from 496/66 tumor/normal samples from The Cancer Genome Atlas (TCGA). Unsupervised clustering of H3K27ac activity cleanly separated tumor from normal individuals, highlighting extensive epigenetic reprogramming during transformation. We developed a novel method to test each chromatin feature for allele-specific activity (asQTL) and evaluate tumor/normal differences in allele-specificity (d-asQTLs) while modelling local structural variation and read overdispersion. At an FDR of 5%, we identified 1,356 unique asQTL chromatin peaks in normal tissues; 2,868 in tumors; and 1,054 d-asQTLs (primarily imbalanced in tumor). The d-asQTL peaks were significantly enriched for RCC GWAS heritability (32x, P=1.8x10-3), more so than any other functional feature including all H3K27ac peaks (12x), super-enhancers (5x), and regions near asQTL genes (4x). Intersection of asQTLs with RCC genome-wide association study (GWAS) data identified putative functional features for 6/17 known loci including tumor-specific activity at SCARB1, which has recently been implicated as a prognostic biomarker in RCC. d-asQTLs were significantly enriched for tumor-specific binding of transcription factors in the hypoxia pathway, implicating a general mechanism for polygenic germline-somatic interaction. Citation Format: Alexander Gusev, Sandor Spisak, Forough Abbasi, Andre Fay, Hallie Carol, Ji-Heui Seo, Toni Choueiri, Kate Lawrenson, Matthew Freedman. Widespread germline-somatic regulatory differences in renal cell carcinoma prioritize risk mechanisms [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr SY25-02.
Repetitive ventricular tachyarrhythmia: result of pacemaker failure
Authors: J. Devorss
Journal: JAMA (1972)

<h3>To the Editor.—</h3> The use of the demand feature in pacemakers has reduced, but not eliminated, problems of arrhythmias.<sup>1</sup>Premature battery depletion and failure of electronic components have continued to be significant problems. We observed an early and unexpected manifestation of pacemaker failure, which was permitted to continue primarily due to a low "threshold" of suspicion, and an unfortunate attitude of faith that the situation would improve. <h3>Report of a Case.—</h3> A 64-year-old man complained of increasing fatigue, dyspnea on exertion, and orthopnea. No history of angina pectoris, myocardial infarction, or rhythm disturbance could be elicited. Findings included the following: blood pressure (BP), 130/70 mm Hg; pulse rate, 45 beats per minute; cannon waves in the jugular veins; a systolic ejection murmur; and an increase in the transverse diameter of the heart by x-ray film. An electrocardiogram revealed normal sinus rhythm, complete heart block, and idioventricular rhythm at a
P15.08 Phase I Trial of in situ Vaccination With Autologous CCL21-Modified Dendritic Cells (CCL21-DC) Combined With Pembrolizumab for Advanced NSCLC
Authors: A. Lisberg, B. Liu, R. Salehi-Rad, J. Lee, L. Tran, K. Krysan, R. Li, Y. Lin, F. Abtin, R. Suh, S. Oh, D. Aberle, L. Winter, W. Wallace, D. Elashoff, E. Garon, S. Sharma, S. Dubinett
Journal: Journal of Thoracic Oncology (2021)
An uncleavable form of pro–scatter factor suppresses tumor growth and dissemination in mice
Authors: Massimiliano Mazzone, Cristina Basilico, Silvia Cavassa, Selma Pennacchietti, Mauro Risio, Luigi Naldini, Paolo M. Comoglio, Paolo Michieli
Journal: Journal of Clinical Investigation (2004)

Scatter factor (SF), also known as hepatocyte growth factor, is ubiquitously present in the extracellular matrix of tissues in the form of an inactive precursor (pro-SF). In order to acquire biological activity, pro-SF must be cleaved by specific proteases present on the cell surface. The mature form of SF controls invasive cues in both physiological and pathological processes through activation of its receptor, the Met tyrosine kinase. By substituting a single amino acid in the proteolytic site, we engineered an unprocessable form of pro-SF (uncleavable SF). Using lentivirus vector technology, we achieved local or systemic delivery of uncleavable SF in mice. We provide evidence that (a) uncleavable SF inhibits both protease-mediated pro-SF conversion and active SF–induced Met activation; (b) local expression of uncleavable SF in tumors suppresses tumor growth, impairs tumor angiogenesis, and prevents metastatic dissemination; and (c) systemic expression of uncleavable SF dramatically inhibits the growth of transplanted tumors and abolishes the formation of spontaneous metastases without perturbing vital physiological functions. These data show that proteolytic activation of pro-SF is a limiting step in tumor progression, thus suggesting a new strategy for the treatment or prevention of the malignant conversion of neoplastic lesions.
Choroidal infiltrates simulating fundal changes of acute leukemia during hematological recovery following high‐dose chemotherapy in acute myelomonocytic leukemia in remission
Authors: Kanjaksha Ghosh, Sandip Mitra, Devendra Hiwase
Journal: American Journal of Hematology (2000)

A young female patient of 18 who was diagnosed to have acute myelomonocytic leukemia (AML M4) developed choroidal infiltrate and fundal changes suggestive of acute leukemia deposits while she was in remission and was recovering from chemotherapy induced myelosuppression. The choroidal infiltrates were associated with peripheral blood and CSF monocytosis. The choroidal lesion resolved on its own in 2 week's time, when the peripheral and CSF monocytosis subsided. Interestingly this patient had pseudo-Chediak Higashi inclusions in leukemic blasts with normal karyotype. Am. J. Hematol. 63:42–45, 2000.
BOOK REVIEWS
Authors: E. G. LEVINE
Journal: JNCI Journal of the National Cancer Institute (1992)

Journal Article BOOK REVIEWS Get access Testicular Cancer: Investigation and Management . Alan Horwich , ed. Baltimore : Williams & Wilkins , 1991 . 373 pp., illus. $89 ELLIS G. LEVINE, M.D. ELLIS G. LEVINE, M.D. Department of Medicine, Division of Solid Tumor Oncology, Roswell Park Cancer Institute, Elm and Carlton StsBuffalo, NY 14263 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 84, Issue 18, 16 September 1992, Pages 1440–1441, https://doi.org/10.1093/jnci/84.18.1440-a Published: 16 September 1992
Interferon suppresses erythromycin metabolism in rats and human subjects
Authors: P Craig
Journal: Hepatology (1993)

Interferon down-regulates expression of cytochrome P-450 3A in male rats. This study explored the hypothesis that interferon therefore decreases the metabolism of drugs catalyzed by cytochrome P-450 3A. Initial experiments in male rats used microsomal erythromycin N-demethylase activity as a probe for cytochrome P-450 3A catalytic activity. After administration of rat interferon-γ, erythromycin metabolism was impaired (53% of control; p < 0.01). This change correlated with the decline in cytochrome P-450 3A–dependent androstenedione 6β-hydroxylase activity, indicating that the decrease in erythromycin N-demethylase activity could be attributed to interferon-mediated suppression of cytochrome P-450 3A. We then used the [14C]N-methyl erythromycin breath test to assess the activity of hepatic cytochrome P-450 3A in rats and human subjects before and after a single dose of interferon. In rats, rat interferon-γ decreased erythromycin metabolism to 57% of control (p < 0.005). In the human study, six patients with chronic active hepatitis C and four healthy controls were examined 20 to 26 hr after receiving a subcutaneous injection of human interferon-α2b. Interferon produced a small decrease (median = 15%; range = 3% to 35%) in erythromycin metabolism (p < 0.05), as determined by 2-hr excretion of 14CO2 in the breath. Thus interferon-mediated suppression of cytochrome P-450 3A is less strong in human subjects than in male rats. Comparison of our data about the effect of interferon on cytochrome P-450 3A activity with earlier observations of a major impairment of theophylline clearance in human beings suggests that in human subjects interferon may have a more important effect on other drug-metabolizing enzymes, such as those of the cytochrome P-450 1A subfamily. However, interferon may produce clinically relevant impairment in the elimination of drugs that are substrates for cytochrome P-450 3A, should such agents have a narrow therapeutic index. (HEPATOLOGY 1993;17:230–235.)
Book Reviews
Authors: J.M. Havenaar, E.M. Hoch, Dongshick Rhee, Chang-Yong Chung, Nossrat Peseschkian, Lester Luborsky, Mauricio Knobel, Jobst Finke, W. Bettschart, G. Klosinski, Imre Szecsödy, A. Zintl-Wiegand, W. Saameli, Manuel Ruiz Ruiz, Antonio Porras Torres, Federico Martin Ortiz, Eduardo Sanchez Guerrero, Salvador Crossa Ramírez, S. Rossmanith, Friedrich Krull, C. Ringer, A. Blaser, M. Thommen, E. Heim, Mauricio Knobel, Raymond Battegay, Heinz Schepank, Suk-Hun Kang, A. Drees, I. Schwarz, John Penman, E. Brown, Reinhold Becker, Manuel Ruiz Ruiz, J.C.C. Badenhorst, Friedrich Krull, Michael Schifferdecker, Antonio Maria Lapenta, Attilio Randone, A. Blaser, Ch. Ringer, M. Thommen, E. Heim, M. Thommen, A. Blaser, Ch. Ringer, E. Heim, Celina Brykczyńska, Ruiz Ruiz, Morales Aranjuez, Calvo Ortega, Pino Blanes, Antón Cortés, Aparicio Aparicio, Gerald G. Pope, Atle Roness
Journal: Psychotherapy and Psychosomatics (1990)
Immunologic Effects of Background Exposure to Polychlorinated Biphenyls and Dioxins in Dutch Preschool Children
Authors: Nynke Weisglas-Kuperus, Svati Patandin, Guy A. M. Berbers, Theo C. J. Sas, Paul G. H. Mulder, Pieter J. J. Sauer, Herbert Hooijkaas
Journal: Environmental Health Perspectives (2000)

Prenatal exposure to polychlorinated biphenyls (PCBs) and dioxins is associated with changes in the T-cell lymphocyte population in healthy Dutch infants. We investigated whether these changes persist into later childhood and whether background exposure to PCBs and dioxins is associated with the prevalence of infectious or allergic diseases and humoral immunity at preschool age. The total study group consisted of 207 healthy mother-infant pairs. We estimated prenatal exposure to PCBs and dioxins by the sum of PCBs 118, 138, 153, and 180 (sigmaPCB) in maternal and cord plasma and in breast-fed infants by the dioxin, planar, and mono-ortho PCB toxic equivalent (TEQ) levels in human milk. At 42 months of age, current body burden was estimated by the PCB in plasma. We assessed the prevalence of infectious and allergic diseases by parent questionnaire, and measured humoral immunity by antibody levels for mumps, measles, and rubella after primary vaccination. We performed immunologic marker analyses of lymphocytes in a subgroup of 85 children. Prenatal PCB exposure was associated with an increased number of lymphocytes, T-cells, and CD3CD8(+) (cytotoxic), CD4(+)CD45RO(+) (memory), T-cell receptor (TcR) [alpha]ss(+), and CD3(+)HLA-DR(+) (activated) T cells and lower antibody levels to mumps and measles at preschool age. Adjusted for confounders, prenatal PCB exposure was associated with less shortness of breath with wheeze, and current PCB body burden was associated with a higher prevalence of recurrent middle-ear infections and of chicken pox and a lower prevalence of allergic reactions. A higher dioxin TEQ was associated with a higher prevalence of coughing, chest congestion, and phlegm. We conclude that in Dutch preschool children the effects of perinatal background exposure to PCBs and dioxins persist into childhood and might be associated with a greater susceptibility to infectious diseases. Common infections acquired early in life may prevent the development of allergy, so PCB exposure might be associated with a lower prevalence of allergic diseases.
Glass in the hand and foot. Will an X-ray film show it?
Authors: D. Tandberg
Journal: JAMA (1982)

Roentgenograms of 66 different kinds of glass fragments embedded in chicken legs were taken to evaluate the roentgenographic detectability of glass in an animal tissue similar in size and structure to the human hand or foot. All 66 specimens were easily seen. The presence of lead or other heavy elements was not required for visualization. Fragments as small as 0.5 mm were easily detected if there was no overlying bone. Standard plain x-ray films of the injured hand or foot are useful in determining whether glass fragments are present in the wound. (<i>JAMA</i>1982;248:1872-1874)
Cooperativity Of RUNX1 and CSF3R Mutations In The Development Of Leukemia In Severe Congenital Neutropenia: A Unique Pathway In Myeloid Leukemogenesis
Authors: Julia Skokowa, Doris Steinemann, Jenny Katsman-Kuipers, Cornelia Zeidler, Olga Klimenkova, Maksim Klimiankou, Murat Uenalan, Siarhei Kandabarau, Vahagn Makaryan, Renee Beekman, Carol Stocking, J Obenauer, Susanne Schnittger, Alexander Kohlmann, M Valkhof, R Hoogenboezem, Gudrun Göhring, Dirk Reinhardt, Brigitte Schlegelberger, Martin Stanulla, Peter Vandenberghe, Jean Donadieu, Michel Zwaan, Ivo P. Touw, Marry M. van den Heuvel-Eibrink, David C. Dale, Karl Welte
Journal: Blood (2013)
Monatsschrift für Kinderheilkunde, Berlin
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medical Bibliography
Authors: Harold Wilson
Journal: JAMA (1910)

A correspondent asks for the formula of "Odol," a some¬ what expensive English toothwnsh.It is advertised to an enormous extent in Great Britain, but has not as yet been given any great degree of publicity in this country.It has been claimed that the preparation is a by-product of the salol factories, though this has been denied.Formulas representing the results of various analyses have appeared in German pharmaceutical journals, and the following, by Aufrecht, is from 1 lager's Handbuch <lcr Pliarmaccutischcn Praxis, Ergän¬ zungsband, Ed. 1!)08.Alcohol .89.00 per cent.Water .8.00 per cent.Menthol .2.00 per cent.Saccharin.0.05 per cent.
Health system reform. Forward or backward with quality oversight?
Authors: T. S. Jost
Journal: JAMA (1994)

IN HIS September 22,1993, health system reform speech to the nation, President Clinton stated: "If we reformed everything else in health care, but failed to preserve and enhance the high quality of our medical care, we will have taken a step backward, not forward." The Health Security Act that the president actually submitted to Congress, however, largely dismantles the system that has evolved for external oversight of the quality of health care in the United States without putting in its place an adequate alternative means to assure health care quality. The most popular congressional alternatives to the Clinton plan give even less attention to quality issues. Indeed, health system reform threatens to take us backward rather than forward with respect to external quality oversight. The field of health care quality oversight has long been characterized by a certain faddishness. Ideologies, methodologies, and programs have come and gone with astonishing rapidity,
Genetics, Ethics
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Epidemic Cholera.
Journal: JAMA (1883)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Error in Homozygote Classification
Journal: JAMA Psychiatry (2014)

Dwight Dickinson, PhD; Richard E. Straub, PhD; Joey W. Trampush, PhD; Yuan Gao, PhD; Ningping Feng, PhD; Bin Xie, PhD; Joo Heon Shin, PhD; Hun Ki Lim, PhD; Gianluca Ursini, MD; Kristin L. Bigos, PhD; Bhaskar Kolachana, PhD; Ryota Hashimoto, MD; Masatoshi Takeda, MD; Graham L. Baum, BS; Dan Rujescu, MD; Joseph H. Callicott, MD; Thomas M. Hyde, MD, PhD; Karen F. Berman, MD; Joel E. Kleinman, MD, PhD; Daniel R. Weinberger, MD
Fiction
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diseases of the Chest, Chicago
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Perirectal infections in patients with small cell lung cancer
Authors: M. F. Earle
Journal: JAMA (1981)

Fifteen anorectal infections occurred in 6.4% of 188 intensively treated patients with small cell bronchogenic carcinoma. Granulocytopenia was present at onset in 13 episodes. In eight episodes, perirectal pain preceded any objective findings by two to 11 days. Ten infections resolved with recovery from granulocytopenia, but the five abscesses required incision. Septicemia accompanied four episodes; one patient died. Early recognition and therapy of this potentially fatal infection will become increasingly important as more patients with solid tumors receive intensive therapy. (<i>JAMA</i>1981;246:2464-2466)