tbuckley/cabot-search huggingface dataset:
Abstract MP069: Dietary Factors Associated with Cardiovascular Outcomes: 25 Year Findings from the Coronary Artery Risk Development in Young Adults (CARDIA) Study
Authors: Linda Van Horn, Hongyan Ning, Lyn Steffen, David Jacobs, James Shikany, Michael Miedema, Jamal S Rana, Kiang Liu
Journal: Circulation (2017)

Background: Recommendations to prevent risk of atherosclerotic cardiovascular disease (ASCVD) include reduced intakes of saturated fat, excess sodium and added sugars. Coronary artery calcium (CAC) develops over many years and is a strong predictor of future ASCVD but data regarding diet and CAC are limited. Methods: Participants from CARDIA with Y25 CAC measurement were included (n= 3,121). CAC presence (Agatston score &gt;0) and incident ASCVD including coronary heart disease (CHD), heart failure (HF) and stroke were assessed from baseline (ages 18-30 y) over a 25 y follow up along with baseline diet assessed by diet history. Results: Mean (SD) age at baseline was 25.1 (3.6) y; 56.7% female, 46.7% black. Prevalence of CAC at Y25 was 28.4% and more likely male (64.7 % vs 34.8%) and white (58.7% vs 51.1%). There were 53 (3.0%) and 75 (5.7%) cases of ASCVD events in women and men respectively over 28.4 y (median: 27.1 y). Intake of saturated fat was not, but added sugars were associated with CAC presence. Intake of butter was seemingly protective for both CAC and ASCVD while sugar-sweetened beverages (SSBs) and sodium (borderline) were associated with incident ASCVD. SSBs were specifically associated with CHD, stroke, and HF. Conclusions: Dietary factors play an important role in development of ASCVD, but the same dietary factors may not necessarily be associated with CAC development. Adverse synergistic effects of sodium and added sugars may be especially related to CVD. Whether source of SFA e.g. meat/processed meat, vs dairy foods confers different ASCVD risks and whether added sugars directly or indirectly in SSB’s increase CAC and a CVD event, especially combined with high sodium intake, need further consideration.
Behavior of various cholesterol crystals in bile from patients with gallstones
Authors: P Portincasa
Journal: Hepatology (1996)

Besides classical plate-like cholesterol monohydrate crystals, a variety of crystal shapes have recently been described in model biles but their relevance for human gallstone formation is unknown. We therefore studied crystallization behavior in gallbladder bile from cholesterol stone patients (54 untreated, 13 ursodeoxycholate-treated) and 6 pigment stone patients. Bile preparation by ultrafiltration or ultracentrifugation left biliary lipid composition unchanged but plates and their aggregates, and arcs and needles crystallized more extensively while spirals and tubules crystallized less extensively in ultra-centrifuged bile than in ultrafiltered bile. Plates, aggregates, and arcs/needles were seen in 90%, 36%, and 18% of the cases respectively of fresh unfiltered biles of untreated cholesterol stone patients, while spirals and tubules were always absent. In ultrafiltered biles arcs/needles, plates and aggregates progressively developed as persistent forms. Spirals and tubules occurred transiently and were associated with increased deoxycholic acid (+41%, P = .039) and with more extensive cholesterol crystallization. Rate/extent of crystallization of all crystal forms was higher (P < .0001) for multiple than solitary cholesterol stone patients. Ursodeoxycholate-treated patients had atypical platelike cholesterol crystals in fresh unfiltered biles that decreased in size at prolonged observation and in 2 cases even dissolved after 15 and 20 days. No crystals ever developed in ultra-filtered bile of ursodeoxycholic acid (UDCA)-treated patients during 21 days. Pigment stone patients seldom developed crystals. Thus, plates, aggregates and arcs/needles are persistent forms with high crystallization rate in multiple cholesterol stone patients. Tubules and spirals are transient forms that are associated with more extensive crystallization. Patients treated with ursodeoxycholate often have atypical crystals in their fresh bile.
Black Dermographism
Authors: Erin Lowe, Scott Lim
Journal: JAMA Dermatology (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
The Chemical Laboratory
Journal: JAMA (1929)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Le bactériophage de d'Hérelle.
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mechanisms of Tolerance to Parental Parathyroid Tissue when Combined with Human Allogeneic Thymus Transplantation
Authors: I.K. Chinn, J.A. Olson, M.A. Skinner, E.A. McCarthy, S.E. Gupton, F.A. Bonilla, R.L. Roberts, M.G. Kanariou, B.H. Devlin, M.L. Markert
Journal: Journal of Allergy and Clinical Immunology (2010)
Management of Graves' Ophthalmopathy: Reality and Perspectives
Authors: L. Bartalena
Journal: Endocrine Reviews (2000)

Graves' ophthalmopathy is an debilitating disease impairing the quality of life of affected individuals.Despite recent progress in the understanding of its pathogenesis, treatment is often not satisfactory.In mild cases, local therapeutic measures (artificial tears and ointments, sunglasses, nocturnal taping of the eyes, prisms) can control symptoms and signs.In severe forms of the disease (3-5%), aggressive measures are required.If the disease is active, high-dose glucocorticoids and/or orbital radiotherapy, or orbital decompression represent the mainstay of treatment.If the disease is severe but inactive, orbital decompression is preferred.Novel treatments such as somatostatin analogs or intravenous immunoglobulins are under evaluation.Re-habilitative (extraocular muscle or eyelid) surgery is often needed after treatment and inactivation of eye disease.Correction of both hyper-and hypothyroidism is crucial for the ophthalmopathy.Antithyroid drugs and thyroidectomy do not influence the course of the ophthalmopathy, whereas radioiodine treatment may cause the progression of preexisting ophthalmopathy, especially in smokers.The exacerbation, however, is prevented by glucocorticoids.In addition, thyroid ablation may prove beneficial for the ophthalmopathy in view of the pathogenetic model relating eye disease to autoimmune reactions directed against antigens shared by the thyroid and the orbit.(Endocrine Reviews 21
GOVERNOR SULZER’S SPECIAL MESSAGE ON PUBLIC HEALTH
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Treatment of gonorrheal urethritis evaluated in 230 men
Authors: E. B. Berry
Journal: JAMA (1967)

During a recent eight-month deployment of an aircraft carrier to the western Pacific, 230 cases of acute gonorrheal urethritis were encountered. Patients were randomly assigned to one of four treatment schedules: (1) procaine penicillin G for ten days; (2) procaine penicillin G in a large single dose; (3) penicillin G potassium for three days; and (4) oxytetracycline. Eradication of the gonococcus was highest with regimens 2 and 4. Cure of gonorrhea and prevention of nongonorrheal urethritis was highest with the oxytetracycline regimen.
The Paranoid
Authors: H. Keith Fischer
Journal: JAMA (1971)

The chief contribution of this book about paranoids and paranoia is its focus on the topic as a syndrome—a constellation of traits and symptoms that constitute a spectrum of paranoid phenomena ranging from relatively minor patterns in seemingly "normal" individuals, to paranoid psychoses. The "paranoid mode of thinking," the paranoid "outlook" or "slant on life," is the basis of the authors' point of view. They observed this in individuals, families, citizens, groups, in relationship to the law, education, medicine, government, religion, racism, and history—in almost everyone, some of the time, and almost everywhere. This focus rests basically on description. It emphasizes characteristics of projective thinking, hostility, suspiciousness, centrality, delusions, fear of loss of autonomy, and grandiosity. The authors, observing the paranoid mode of thinking in a large group of major and minor clinical entities and as a complication of other syndromes, discuss biological, psychological, and social factors. Yet these comprise
Annual Convention Announcement
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 206: Mitofilin Knockdown Induces Cell Death by Apoptosis via an AIF-PARP-dependent Mechanism and Cell Cycle Arrest
Authors: Jean C Bopassa, Ngonidzashe B Madungwe, Yansheng Feng, Mihaela Lie
Journal: Circulation Research (2017)

Introduction: Mitochondrial activity plays an essential role in the efficient function of cardiomyocytes. Mitofilin is an inner membrane protein that has been defined as a mitochondria-shaping protein in controlling and maintaining mitochondrial cristae structure and remodeling. In this study, we determined the role of mitofilin in H9c2 and C2C12 myoblasts survival by investigating the mechanism underlying mitofilin knockdown-induced cell death by apoptosis. Methods: H9c2 and C2C12 cells were cultured and treated with mitofilin siRNA or scramble siRNA for 24 hours. Cell death (apoptosis), caspase 3 activity, and cell cycle phases were assessed by flow-cytometry, cytochrome C release and intracellular ATP production were measured by ELISA. Mitofilin, AIF and PARP expression was measured by Western blot analysis and calpain activity assessed using calpain kit. Mitochondria images were taken using electron microscopy. Results: We found that mitofilin knockdown increases cell death by apoptosis mainly via activation of AIF pathway leading to nuclear fragmentation and subsequent PARP1 activation in the nucleus that is correlated with S phase arrest of the cell cycle. Knockdown of mitofilin in H9c2 as well as C2C12 myoblasts with siRNA led to mitochondrial swelling and damage of mitochondrial cristae that is associated with the increase in ROS production, decrease in intracellular ATP production and a marked decrease in mitochondrial membrane potential. Moreover, cells treated with mitofilin siRNA displayed an increase in calpain activity versus scramble siRNA. Conclusion: Together, these results indicate that mitofilin knockdown by siRNA increases calpain activity that presumably leads to mitochondrial structural degradation resulting in a critical reduction of mitochondrial function that is responsible for the increase in cell death by apoptosis via AIF-PARP mechanism which is associated with nuclear fragmentation and S phase arrest of cell cycle.
New Names
Journal: JAMA (1981)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cardiovascular Effects of 3,4-Methylenedioxymethamphetamine (MDMA, “Ecstasy”)
Journal: Annals of Internal Medicine (2000)

Summaries for Patients19 December 2000Cardiovascular Effects of 3,4-Methylenedioxymethamphetamine (MDMA, “Ecstasy”)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-133-12-200012190-00007 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?3,4-Methylenedioxymethamphetamine, also known as MDMA and “ecstasy,” is a stimulant drug that is widely used in nonmedical settings, such as nightclubs. The use of MDMA appears to be increasing. It is estimated that over 7 out of every 100 young adults have used MDMA at some time in their lives. Although MDMA can result in serious heart-related complications and death, little is known about what exactly MDMA does to blood pressure and heart function.Why did the researchers do this particular study?To study how MDMA affects the ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Cardiovascular Effects of 3,4-Methylenedioxymethamphetamine. A Double-Blind, Placebo-Controlled Trial.” It is in the 19 December 2000 issue of Annals of Internal Medicine (volume 133, pages 969-973). The authors are SJ Lester, M Baggott, S Welm, NB Schiller, RT Jones, E Foster, and J Mendelson.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. Previousarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoCardiovascular Effects of 3,4-Methylenedioxymethamphetamine: A Double-Blind, Placebo-Controlled Trial Steven J. Lester , Matthew Baggott , Susette Welm , Nelson B. Schiller , Reese T. Jones , Elyse Foster , and John Mendelson Metrics 19 December 2000Volume 133, Issue 12Page: I-64KeywordsBlood pressureCardiac outputDrugsHeartHeart rateLongitudinal studiesMDMAMyocardiumUltrasound imagingYoung adults ePublished: 19 December 2000 Issue Published: 19 December 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Software
Authors: T. Keith Edwards
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Soviets, Americans allied in new war; common foe this time: alcohol abuse
Authors: T. F. Kirn
Journal: JAMA (1987)

AN AMERICAN we will call Ernie, from Akron, Ohio, is sitting at a long table in an official meeting room in Moscow, opposite Soviet government officials and medical researchers. The broad-nosed, square-chinned, former blue-collar worker tells the story of the time a drunk driver hit his car. In the emergency department following the accident, he approached the other driver's wife and said, "I hope I see Bill in an AA [Alcoholics Anonymous] meeting soon." Looking puzzled, he says, she asked, "Who are you?" "I'm the guy in the other car," Ernie says he answered. Explaining his sentiment to the Soviets, Ernie says: "It's terrible when it happens to you, but I couldn't get angry with him. I know what he's going through." Welcome to the first US-Soviet Dialogue on Common Problems, focusing on alcohol problems, and the next to the last day of a two-week exchange program that brought 16
Historical Errors.
Authors: N. S. Davis.
Journal: JAMA (1903)

Chicago, July 20, 1903. <i>To the Editor:</i>—InThe Journalof the American Medical Association, July 18, 1903, p. 195, it is stated, under the head of deaths, that the late Dr. DeLaskie Miller of Chicago was "born in New York City," graduated from "Syracuse Medical College in 1842," which is evidently erroneous. According to reliable authority Dr. Miller was born in Niagara County, New York, May 29, 1818, and graduated from Geneva Medical College, New York, in 1842, there being at that date no medical college in Syracuse. On page 196 ofThe Journalit is stated that the New Jersey State Medical Society was organized in 1776, which is ev-dently erroneous. According to reliable authorities that state society, the oldest in the country, was organized in 1766, and held its meetings annually until they were interrupted by the Revolutionary War in 1776; but they were as the exigencies