tbuckley/cabot-search huggingface dataset:
THE PHYSIOLOGICAL RESPONSE, TIME-MOTION CHARACTERISTICS AND REPRODUCIBILITY OF VARIOUS SPEED ENDURANCE DRILLS IN ELITE YOUTH SOCCER PLAYERS: SMALL SIDED GAMES VS GENERIC RUNNING
Authors: J Ade, J Harley, P Bradley
Journal: British Journal of Sports Medicine (2013)

The aim of the study was to quantify the physiological responses, time-motion characteristics and reproducibility of various speed endurance production (SEP) and speed endurance maintenance (SEM) drills. Twenty-one elite male youth soccer players completed four drills: (1) SEP 1 v 1 small sided game, (2) SEP running drill, (3) SEM 2 v 2 small sided game and (4) SEM running drill. The SEP drills consisted of eight bouts of 30 s with 120 s recovery (1:4 exercise to rest ratio) whilst SEM drills encompassed eight bouts of 60 s with 60 s recovery (1:1 exercise to rest ratio). Heart rate response, blood lactate concentration, rating of perceived exertion and time-motion characteristics were recorded for each drill. The SEP and SEM running drills elicited greater ( P &lt;0.05) heart rate responses, blood lactate concentrations and subjective ratings of perceived exertion than the equivalent small sided games (ES: 1.1–1.4 &amp; 1.0–3.2). Players covered less ( P &lt;0.01) total distance, high-, very high-speed running and sprint distance in the SEP and SEM small sided game's compared to the equivalent running drills (ES: 6.0–22.1 &amp; 3.0–18.4). Greater distances ( P &lt;0.01) were covered in high and maximum acceleration/deceleration bands during the SEP and SEM small sided game's compared to the equivalent running drills (ES: 2.6–4.6 and 2.3–4.8). Small-moderate test-retest variability was observed for heart rate response (CV: 0.9–1.9%), ratings of perceived exertion (CV: 2.9–5.7%) and blood lactate concentration (CV: 9.9–14.4%); Moderate-large test-retest variability was observed for high-intensity running parameters (CV: &gt;11.3%) and the majority of acceleration/deceleration distances (CV: &gt;9.8%) for all small sided games and running drills. The data demonstrate the differential response of SEP and SEM training for taxing various energy systems and the superior acceleration/deceleration profiles of small sided games compared to generic running drills.
Cancer of the head and neck. Nasopharyngeal cancer
Authors: P. Rubin
Journal: JAMA (1972)

The nasopharynx is a small boxlike structure at the top of the pharyngeal cylinder. Neoplasms spread in two directions, each leading to distinct neurological signs. Direct extension through the foramen lacerum into the cavernous sinus and middle fossa of the skull leads to the involvement of cranial nerves III, IV, V, VI, and more rarely cranial nerve II. By contrast, spread to the lateral pharyngeal nodes in and about the carotid jugular sheath in the retroparotidian space results in infiltration of cranial nerves IX, X, XI, and XII. Usually cranial nerves VII and VIII are spared. Knowledge of the cranial nerve anatomy is critical to appreciate the extent of disease, and evaluate the patterns of spread. <h3>Current Classifications.—Tumor, Node, Metastasis (TNM) System.—</h3> Both the Union International Contre le Cancrum (International Union Against Cancer [UICC])<sup>1</sup>and the American Joint Committee for Cancer Staging and End Results Reporting
Oral Tolerance
Authors: K. M. SMITH, A. D. EATON, L. M. FINLAYSON, P. GARSIDE
Journal: American Journal of Respiratory and Critical Care Medicine (2000)

Section:ChooseTop of pageAbstract <<WHERE AND WHY? ROLE OF TH...HOW? POTENTIAL MECHANISMS...DELETIONREGULATORY T CELLSREGULATORY CYTOKINESCOGNATE INTERACTIONReferencesCITING ARTICLES
Preparation of the vagina for surgery. A comparison of povidone-iodine and saline solution
Authors: M. S. Amstey
Journal: JAMA (1981)

Patients undergoing major vaginal surgery and treated with prophylactic antibiotics were assigned to two groups in which the effectiveness of preoperative vaginal preparation with povidone-iodine was compared with that of saline solution. There was no difference in postoperative morbidity between the two groups, although a few more infections occurred in the group treated with povidone-iodine. It is suggested that simple dilution of the quantity of bacteria in the vagina is all that is essential for adequate preoperative vaginal preparation. (<i>JAMA</i>1981;245:839-841)
Author Disclosures for Late-Breaking Abstracts
Authors: Julie Berube, L7 Nothing, Bradley Bloom, Hgt Shire, Irene Borras, David Camann, L8 Nothing, Klara Eriksson, L10 Nothing, Henriette Farkas, Alison Humbles, Medimmune Llc, Kyung Hwa, L8 Kolbeck, L1 Levy, Csl Behring, Dyax Corp, H Henry
Journal: Journal of Allergy and Clinical Immunology (2011)
The Parade
Authors: John L. Wright
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury
Authors: Koichi Obata, Hirokazu Katsura, Toshiyuki Mizushima, Hiroki Yamanaka, Kimiko Kobayashi, Yi Dai, Tetsuo Fukuoka, Atsushi Tokunaga, Makoto Tominaga, Koichi Noguchi
Journal: Journal of Clinical Investigation (2010)

During the preparation of the manuscript, the number of samples used for the quantification of RT-PCR depicted in Figure 2E was stated incorrectly.The corrected legend appears below.(E) mRNA expression of TRPA1 and TRPM8 in the DRG after inflammation, as detected by RT-PCR.Quantification of RT-PCR data is shown at right.Data represent mean ± SD; n = 3 per group.*P < 0.05 compared with the naive control.
Cephaloridine encephalopathy.
Authors: R Taylor, R Arze, R Gokal, J C Stoddart
Journal: BMJ (1981)

cefoxitin agar (Oxoid) selective for Cl difficile.Methods of identification of isolates and tests for Cl difficile cytotoxin in stools are described elsewhere.4Typing was attempted by testing all strains against 20 antibiotics using a conventional disc sensitivity method.Over eight months Cl difficile was recovered from 10 patients, seven of whom had undergone antibiotic gut decontamination (see figure).All had Case no Age Sex
Phase III results for the novel neurokinin-1 (NK-1) receptor antagonist, casopitant: 3-day IV/oral dosing regimen for chemotherapy-induced nausea and vomiting (CINV) in patients (Pts) receiving moderately emetogenic chemotherapy (MEC)
Authors: Z. Aziz, W. Arpornwirat, J. Herrstedt, I. Camlett, T. Piontek, S. Ranganathan, J. Schnyder, R. R. Bandekar, J. Levin, A. Shaharyar
Journal: Journal of Clinical Oncology (2008)

20512 Background: In a phase III trial, 3 dosing regimens of casopitant, a novel NK-1 receptor antagonist, were evaluated for efficacy in reducing the number of pts experiencing emesis from initial and subsequent cycles of MEC: single oral, 3-day oral, and 3-day IV/oral dosing. Reported here are the results for the 3-day IV/oral regimen of casopitant combined with ondansetron/dexamethasone (OND/DEX) for pts receiving anthracycline and cyclophosphamide (AC)-based MEC. Methods: This multinational, double-blind, active-controlled trial included 1933 pts with breast cancer (96%). All pts received DEX 8 mg IV D1 + OND 8 mg BID PO D1–3. Pts were randomized to receive no additional therapy (CTRL), a 3-day IV/oral regimen (90 mg IV D1 + 50 mg PO D2–3), a single oral dose (150 mg PO D1), or a 3-day oral dose (150 mg PO D1 + 50 mg PO D2–3) of casopitant. Pts continued on therapy up to 4 cycles. Complete Response (CR; no vomiting/retching, rescue medications) in the first 120 hrs after each cycle of an AC-based MEC regimen was the primary endpoint. Results: Addition of a 3-day IV/oral regimen of casopitant to OND/DEX produced a statistically significant improvement (at a 1.67% level of significance adjusted for three primary comparisons) in overall CR rates compared with CTRL, which appeared to be maintained through 4 cycles of MEC. Casopitant was generally well tolerated with AE frequency similar across the arms. Common AEs were neutropenia, alopecia, fatigue, leukopenia, and constipation. Conclusions: A 3-day IV/oral dosing regimen of casopitant added to OND/DEX provided a clinically meaningful improvement in the reduction of emetic events in pts receiving initial and repeat cycles of MEC. Over all cycles, casopitant was generally well tolerated. Cycle of MEC Endpoints (0–120 hrs) CTRL n=479 (%) Casopitant 90 mg IV D1 + 50 mg PO D2–3 n=479 (%) P- value 1 Complete Response 284/479 (59) 353/479 (74) <0.0001 Acute (0–24 hrs) 406 (85) 412 (86) 0.5835 Delayed (24–120 hrs) 284 (59) 353 (74) <0.0001 No vomiting 304 (63) 373 (78) <0.0001 2 Complete Response 236/377 (63) 308/378 (81) NA 3 Complete Response 222/333 (67) 276/343 (80) NA 4 Complete Response 200/289 (69) 254/304 (84) NA Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Expert Testimony Other Remuneration GlaxoSmithKline GlaxoSmithKline GlaxoSmithKline GlaxoSmithKline
Interaction of alkylmercuric compounds with sodium selenite. III. Biotransformation, levels of metallothioneinlike proteins and endogenous copper in some tissues of rats exposed to methyl or ethylmercuric chloride with and without sodium selenite.
Authors: E A Brzeźnicka, J Chmielnicka
Journal: Environmental Health Perspectives (1985)

The biotransformation efficiency of alkylmercurial compounds was studied in rat liver, kidneys, blood, and brain after 2-week administration of methylmercuric chloride (MeHg) and ethylmercuric chloride (EtHg) at doses of 0.25 or 2.5 mg Hg/kg, alone or in combination with sodium selenite (Se) at a level of 0.5 mg Se/kg. Simultaneously, the level of metallothioneinlike proteins (MTP) and endogenous copper (Cu) was monitored in tissues of control rats and intoxicated rats. Regardless of the dose, the highest concentrations of inorganic mercury from both the alkylmercurials was found in the rat kidneys. Sodium selenite had a variable effect on the amount of inorganic mercury liberated, depending on the organ and the molar ratio of Hg:Se administered. A statistically significant increase in the levels of MTP and endogenous Cu, compared with control group, was found only in the kidneys of intoxicated rats. This increase was dependent on the concentration of inorganic mercury liberated by biotransformation of alkylmercurials. The observed changes appeared when the level of inorganic mercury exceeded 10 micrograms Hg/g tissue and reached a plateau at about 40 micrograms Hg/g tissue. In the presence of selenium the plateau of MTP and Cu levels were no observed in the kidneys, regardless of the amount of inorganic mercury liberated.
Two-Year Pulmonary Safety and Efficacy of Inhaled Human Insulin (Exubera) in Adult Patients With Type 2 Diabetes
Authors: Julio Rosenstock, William T. Cefalu, Priscilla A. Hollander, Andre Belanger, Freddy G. Eliaschewitz, Jorge L. Gross, Solomon S. Klioze, Lisa B. St. Aubin, Howard Foyt, Masayo Ogawa, William T. Duggan
Journal: Diabetes Care (2008)

OBJECTIVE—The purpose of this study was to evaluate the 2-year pulmonary safety of inhaled human insulin (Exubera [EXU]) in 635 nonsmoking adults with type 2 diabetes. RESEARCH DESIGN AND METHODS—Patients were randomly assigned to receive prandial EXU or subcutaneous insulin (regular or short-acting) plus basal (intermediate- or long-acting) insulin. The primary end points were the annual rate of decline in forced expiratory volume in 1 s (FEV1) and carbon monoxide diffusing capacity (DLCO). RESULTS—Small differences in FEV1 favoring subcutaneous insulin developed during the first 3 months but did not progress. Adjusted treatment group differences in FEV1 annual rate of change were −0.007 l/year (90% CI −0.021 to 0.006) between months 0 and 24 and 0.000 l/year (−0.016 to 0.016) during months 3–24. Treatment group differences in DLCO annual rate of change were not significant. Both groups sustained similar reductions in A1C by month 24 (last observation carried forward) (EXU 7.7–7.3% vs. subcutaneous insulin 7.8–7.3%). Reductions in fasting plasma glucose (FPG) were greater with EXU than with subcutaneous insulin (adjusted mean treatment difference −12.4 mg/dl [90% CI −19.7 to −5.0]). Incidence of hypoglycemia was comparable in both groups. Weight increased less with EXU than with subcutaneous insulin (−1.3 kg [−1.9 to −0.7]). Adverse events were comparable, except for a higher incidence of mild cough and dyspnea with EXU. CONCLUSIONS—Two-year prandial EXU therapy showed a small nonprogressive difference in FEV1 and comparable sustained A1C improvement but lower FPG levels and less weight gain than seen in association with subcutaneous insulin in adults with type 2 diabetes.
Quotations
Authors: Stephen Lurie
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Rectal Hydrocortisone
Authors: J. D. N. Nabarro, A. Moxham, G. Walker, J. D. H. Slater
Journal: BMJ (1957)

<h3>Objective</h3> Sjögren syndrome (SS) has a significant impact on health-related quality of life (HRQOL). We sought to evaluate how the Patient Reported Outcome Measurement Information System (PROMIS) domains in SS may supplement the European League Against Rheumatism (EULAR) Sjögren Syndrome Patient Reported Index (ESSPRI). <h3>Methods</h3> A cross-sectional evaluation was performed on consecutive adult patients during visits to an SS clinic between March 2018 and February 2020. Each patient completed PROMIS short forms related to HRQOL and the ESSPRI, and had a clinical assessment. Patients were either classified as SS by 2016 American College of Rheumatology (ACR)/EULAR criteria, or as “sicca not otherwise specified (NOS)” and used as a comparison group. Univariable and multivariable linear regression models were used to evaluate predictors of PROMIS fatigue (-F), pain interference (-PI), and ability to participate in social roles and activities (-APS). <h3>Results</h3> Two hundred twenty-seven patients with SS and 85 with sicca NOS were included and did not differ in ESSPRI domains; 26% of the SS and 20% of the sicca NOS group had concurrent autoimmune disease. In SS, PROMIS-PI, PROMIS-F, and PROMIS physical function were at least one-half SD worse than US population normative values. PROMIS-PI (<i>r</i> = 0.73) and PROMIS-F (<i>r</i> = 0.80) were highly correlated with ESSPRI pain and fatigue subdomains. Fatigue and pain interference, but not dryness or mood disturbance, were the strongest predictors of social participation in multivariable analysis. <h3>Conclusion</h3> In our SS cohort, PROMIS instruments identified a high disease burden of pain interference, fatigue, and physical function. PROMIS-F strongly predicted PROMIS-APS. PROMIS-PI and PROMIS-F scores correlated highly with their respective ESSPRI domains. PROMIS instruments should be considered to identify relevant HRQOL patterns in SS.
This Week in <i>JAMA</i>
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Paternalism, family duties, and my aunt Maude
Authors: George R. Beauchamp
Journal: JAMA (1988)

<h3>To the Editor.—</h3> I applaud the values-based approach of Dr Miles<sup>1</sup>in his commentary entitled "Paternalism, Family Duties, and My Aunt Maude." In it, Dr Miles questions the appropriateness of uniform acceptance of autonomy as the overriding value in considering such surgical procedures as cataract extraction. This is a course that may benefit certain patients, yet places significant moral and medical burdens on families and practitioners alike. Given the vulnerability of individuals with limited function, including those in extendedcare and nursing facilities, these burdens are amplified.<sup>2</sup> Dr Miles' characterization of cataract surgery as "trivial" is open for considerable debate. Such a characterization is probably inconsistent with the expectations and elemental concerns of most who undergo the procedure. I believe it certainly is inconsistent with the care, precision, education, commitment, and values of most ophthalmologists. Additionally, Dr Miles refers to "cataract repair"; this is an unusual descriptive phrase, of
Heparin Therapy
Authors: Theodore H. Spaet
Journal: JAMA (1980)

Although heparin sodium has been used as an antithrombotic drug for almost half a century, few medications with this seniority share its history as an agent that generates such individuality of use. Thus, many years and vast numbers of studies were required to establish its lack of efficacy in arterial occlusive disease. Prophylactic use of heparin in the prevention of venous thrombi is under continuing study; details of its administration for established thromboembolic disease continue to provoke heated controversy. Only recently have dosage schedules and recommended monitoring of effect achieved a modicum of uniformity, and continuous drip is gradually replacing intermittent push as the chief mode of administration. Concurrence by heparinizers on duration of therapy and associated administration of the coumarin drugs is still minuscule. Although there is now virtually universal agreement that heparin therapy is useful in preventing the extension and embolic complications of venous thrombosis, its potential for
Dermatology
Authors: E. Dorinda Loeffel
Journal: JAMA (1977)

Although the preface of this work calls it a successor to the earlier<i>Dermatology</i>by Pillsbury-Shelley-Kligman (published in 1956) rather than a revision, the issue is probably one of semantics. Dermatologists who trained during the period when the original "Pillsbury" was the bible of dermatologic teaching in America will be pleased to note a strong family resemblance between the two works. Several chapters have successfully withstood the test of time, appearing almost verbatim in the new work, except for updating of treatment and terminology. Practically unchanged are sections on the principles of clinical diagnosis, examination, and morphology as well as descriptions of viral, fungal, bacterial, and syphilitic infections. Basic organization also remains the same, and many of the 1,094 black and white photographs are repeats from the earlier work. A new image of the book emerges, however, through inclusion of several entirely new chapters written by 43 contributors who are