tbuckley/cabot-search huggingface dataset:
Semaine des Hôpitaux: Ann Pédiat, Paris
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
From the NIH: Studying hyperactive children with unique monitoring device
Journal: JAMA (1983)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
From the Centers for Disease Control. HIV seroprevalence among adults treated for cardiac arrest before reaching a medical facility
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Silver Stools
Authors: Gerald M. Lawrie
Journal: JAMA (1980)

<h3>To the Editor.—</h3> I read with interest the article of Ong and Pintauro (242:2433, 1979). However, their statement that "only one relatively modern textbook discusses this sign and its importance" is incorrect. This sign is well described in the 13th edition of perhaps the most famous and popular textbook of clinical signs ever published—the classic work of Hamilton Bailey,<i>Demonstrations of Physical Signs in Clinical Surgery</i>.<sup>1</sup>He states that the silver stool is the color of aluminum paint and is due to a mixture of the black (melaena) stool with white fatty stool. In jaundiced patients of mature age the silver stool is fairly characteristic of carcinoma of the ampulla of Vater. The silver stool occurs also in tropical sprue and in children recovering from diarrhea when sulphonamides have been administered. Inexplicably, this sign has been omitted from the 15th edition of this work. This report illustrates the hazards of
Is prostate cancer screening analogous to lung cancer screening?
Authors: P. C. Walsh
Journal: JAMA (1997)

<h3>To the Editor.</h3> —Is prostate cancer more like breast cancer or lung cancer? For reasons that are hard to fathom, Drs Collins and Barry<sup>1</sup>feel that it is more like lung cancer. They dismiss the parallels between prostate cancer screening and breast cancer screening without comment and then focus on the flawed studies in lung cancer that failed to demonstrate a survival benefit.<sup>2</sup>In doing so, they conveniently ignore 2 major flaws in their own logic. First is tumor biology. Prostate cancer is characterized by a slow, natural progression of the disease,<sup>3</sup>whereas the clinical course of lung cancer is frequently established before it can be seen on x-ray examination. For example, by the time the diagnosis of small cell carcinoma of the lung is established, dissemination to distant organ sites has almost always occurred.<sup>4</sup>In lung cancer studies, small cell cancer has comprised 25% of cases.<sup>2</sup>This
ECG for EEG
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Milestones in treatment: the tipping point and the ResQ Trial
Authors: Nicolas Segal, Patrick Plaisance
Journal: The Lancet (2011)

In his Comment1 on the ResQ Trial,2 Peter Nagele suggests that enrolment of a larger cohort could have changed the findings of the ResQ Trial. However, figure 5 of the study shows results with an evident temporal consistency of the beneficial effect, making it extremely unlikely that the results would change.
Breast Lumps
Authors: Stuart Rubenstein
Journal: JAMA (1976)

<h3>To the Editor.—</h3> I would like to take issue with Dr Eckert's statement concerning mammography, "we have not found roentgenograms helpful in assessing the status of a dominant mass, for in this instance histological diagnosis is essential regardless of the roentgenographic findings." On the contrary, xerography is still useful in helping to plan the management of the patient's condition prior to biopsy since "there is an 80% to 90% positive correlation with biopsy.<sup>1</sup>If xerography is interpreted as suggestive or indicative of cancer, the patient's preoperative evaluation should attempt to rule out disseminated disease (via skeletal survey, bone scan, and other comparable means) before radical mastectomy is undertaken. If the xerography was not suggestive of a malignant disease, only a biopsy should be performed on the dominant mass. Then, if the biopsy specimen proved malignant, a similar search should be made for disseminated disease before undertaking radical mastectomy. Following
Medical competence and performance assessment. A new era
Authors: D. G. Langsley
Journal: JAMA (1991)

Historically, the competence of physicians has been based on peer review of their performance. Formal assessment at the time of licensure and certification has been done by cognitive testing, a relatively easy method that is supported by a science of psychometrics. The assessment of actual performance has been less scientific, but that is changing. The National Board of Medical Examiners (NBME) and the Educational Commission for Foreign Medical Graduates (ECFMG) are developing tests of clinical skills using standardized patients for live or electronic simulations. Specialty boards are seeking standardized evaluations of residency performance as part of the certification process. Licensure boards propose to develop a final step of their examinations that will test the cognitive processes used by experienced clinicians. As recertification moves toward an evaluation of practice, there is a call for competence evaluations that will also examine practice performance. These may use a battery of techniques such as
Philippe Ricord (1800-1889), syphilographer
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
<i>The Psychological Review</i>. Series of Monograph Supplements, Vol. IV. (Whole No. 17), January, 1903.<i>Howard Psychological Studies</i>, Vol. I, Containing Sixteen Experimental Investigations from the Harvard Psychological Laboratory. Edited by Hugo Münsterberg. (Published Bi-Monthly by The MacMillan Company, 41 N. Green St., Lancaster, Pa)
Journal: American Journal of Psychiatry (1903)
The attending physician. Privilege and pitfalls
Authors: J. B. Reuler
Journal: JAMA (1980)

THE GOALS of medical education today, both at the undergraduate and graduate levels, are thwarted by a multitude of forces. Medical school enrollments are increasing. Academic and administrative demands on the faculty abound. Financial difficulties plague the institutions. The public is dissatisfied with and distrustful of the profession. House staff clamors for more tolerable working conditions. Within this milieu patients must be cared for and trainees instructed. Central to the successful provision of quality medical education and patient care stands the attending physician. His strengths, however, have become dissipated out of need for self-preservation in the pursuit of more tangible, more remunerative activities. As attending physicians for students and house officers, through discussions with students from visiting medical schools, and from interviewing applicants for house staff training, we have identified several problems. Students and house officers are rarely counseled about their performance, whether good or bad. Often the student reaches
A phase 1b dose-escalation study of TRC105 (anti-endoglin antibody) in combination with axitinib in patients with metastatic renal cell carcinoma (mRCC).
Authors: Toni K. Choueiri, Edwin M. Posadas, Guru Sonpavde, Robert A. Figlin, Meghara K. Walsh, Kevin C. Wall, Ben K. Seon, Manoj A. Jivani, Bonne J. Adams, Charles P. Theuer
Journal: Journal of Clinical Oncology (2014)

e15562 Background: Endoglin (CD105) is an endothelial cell membrane receptor highly expressed on tumor vessels that is essential for angiogenesis and upregulated by hypoxia and VEGF inhibition. TRC105 is an anti-endoglin monoclonal antibody that potentiates bevacizumab and VEGF receptor tyrosine kinase inhibitors (VEGFR TKI) in preclinical models, and has demonstrated activity with bevacizumab in refractory patients with colorectal and ovarian cancer. Methods: Heavily-pretreated mRCC pts with ECOG PS 0-1, and acceptable organ function were treated with intravenously administered TRC105 weekly (8mg/kg and then 10mg/kg) in combination with axitinib (5 mg) given twice daily of each 28 day cycle. Patients were assessed for safety, PK, and response. Results: Six patients (median age = 65; M:F 5:1; all of whom received prior VEGFR TKI, median number of prior therapies = 2.5) have been treated. TRC105 dose escalation proceeded from 8 mg/kg (n=3) to 10mg/kg (n=3) without the development of dose limiting toxicity. Patients experienced expected TRC105 related adverse events of grade 2 infusion reaction and grade 1 epistaxis, gingival bleeding, headache, rash, and fatigue; and expected axitinib adverse events of grade 1-3 hypertension, grade 1 hand-foot syndrome and grade 1 proteinuria. Two patients dosed with 8 mg/kg developed grade 2 creatinine elevations that reversed with hydration. Adverse events characteristic of each drug were not increased in frequency or severity when both drugs were administered concurrently. Four of five evaluable VEGFR TKI refractory patients demonstrated decreases in tumor burden ranging from 6% to 36% (including unconfirmed partial response per RECIST in an ongoing patient) at two to four months following treatment. Pharmacokinetic and immunogenicity studies will be reported. Conclusions: TRC105 at 8 and 10 mg/kg was well tolerated with axitinib in RCC patients. Additional patients will be enrolled at the MTD of both drugs prior to initiating a randomized phase 2 trial of the combination. Clinical trial information: NCT01806064.
Mosaic Turner's syndrome with unusual manifestations
Authors: K. J. Ho
Journal: JAMA (1970)

<h3>To the Editor.—</h3> Mosaic variants of Turner's syndrome have been reported to occur in about 20% of the cases and they show wide variations in their phenotypes.<sup>1-4</sup>This report represents a case of Turner's syndrome with mosaic chromosomal abnormalities and unusual manifestations such as normal ovaries, multiple cardiac anomalies, and partial situs inversus. To our knowledge, the latter two manifestations have not been reported previously. <h3>Report of a Case.—</h3> An infant weighing 2,500 gm was born at 36 weeks gastation on Dec 19, 1969, to a 31-year-old gravida 7, para 2, white mother. Bradycardia (40 to 60 beats per minute) of the baby had been noted in prenatal examinations. Moderate cyanosis, hepatosplenomegaly, and a grade 4/6 systolic murmur were present at birth. The Apgar score was 5. The baby had low-set ears, a low hair line, a short and webbed neck, a shield chest with widely spaced nipples, and
Dantrolene
Authors: Stephen A. Shaivitz
Journal: JAMA (1974)

<h3>To the Editor.—</h3> Dantrolene was introduced early this year for the treatment of spasticity. The drug works directly on the contractile mechanism of skeletal muscle, beyond the myoneural junction; and it is therefore the first drug that directly relaxes muscle itself. Some of the reported side effects have included drowsiness, dizziness, weakness, constipation, gastrointestinal bleeding, and gastric irritation. In addition, there have been some mild central nervous system side effects. We have recently become aware of the possibility that this drug produces constipation, which, if it progresses, may lead to functional small- and large-bowel obstruction. My five associates and I have treated 75 patients with dantrolene this year and have seen three such complications. <h3>Report of Cases.—Case 1.—</h3> A 58-year-old woman with metastatic adenocarcinoma of the colon had a colectomy in October 1970, without sign of local recurrence. In April 1974, because of a left hemiparesis with spasticity
A Guide to the Clinical Examination of the Blood for Diagnostic Purposes.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Suppression of amylase activity by hypertriglyceridemia
Authors: R. W. Fallat
Journal: JAMA (1973)

Patients with clinical acute pancreatitis or abdominal crises possibly indicating surgery, accompanied by lactescent plasma and "normal" serum amylase values, pose a therapeutic dilemma of medical supportive therapy vs prompt surgical intervention. Plasma triglyceride levels in the 500 to 6,000 mg/100 ml range (with grossly turbid plasma) interfere in vitro with determination of amylase activity. In three patients with clinical pancreatitis (normal undiluted serum amylase levels) and lactescent plasma with type V hyperlipoproteinemia, serum amylase level was shown to be elevated after correction for dilution. Serial dilutions of serum with saline solution allow correction to "actual" amylase in hyperlipemic serum, apparently by reducing in vitro interference caused by elevated triglyceride levels.
Medical News
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Somatomedin Hypothesis: 2001
Authors: D. Le Roith
Journal: Endocrine Reviews (2001)

Since the original somatomedin hypothesis was conceived, a number of important discoveries have allowed investigators to modify the concept. Originally somatic growth was thought to be controlled by pituitary GH and mediated by circulating insulin-like growth factor-I (IGF-I, somatomedin C) expressed exclusively by the liver. With the discovery that IGF-I is produced by most, if not all, tissues, the role of autocrine/paracrine IGF-I vs. the circulating form has been hotly debated. Recent experiments using transgenic and gene-deletion technologies have attempted to answer these questions. In the liver-specific igf-1 gene-deleted mouse model, postnatal growth and development are normal despite the marked reduction in circulating IGF-I and IGF-binding protein levels; free IGF-I levels are normal. Thus, the normal postnatal growth and development in these animals may be due to normal free IGF-I levels (from as yet unidentified sources), although the role of autocrine/paracrine IGF-I has yet to be determined.
Rare diseases
Authors: C M ROBERTS;, A E TATTERSFIELD, R M DU BOIS
Journal: Thorax (1999)

An 11 year old boy with cystic fibrosis suffered a stroke, producing right sided weakness.Four years previously a totally implantable venous access device (Port-a-Cath) had been inserted.Magnetic resonance angiography revealed a filling defect in the left middle cerebral artery.Transoesophageal echocardiography demonstrated a thrombus attached to the tip of the Port-a-Cath and also the presence of a patent foramen ovale.After an initial period of anticoagulation the defect was closed using a septal occlusion device introduced via a cardiac catheter.The boy's neurological signs completely resolved and he remains free from further thromboembolic episodes.Whilst pulmonary embolism has been described before in relation to a totally implantable venous access device, this is believed to be the first description of a paradoxical embolism in relation to such a device.
Pseudoarrhythmia caused by temporary transvenous pacemaker
Authors: M. Rubenfire
Journal: JAMA (1976)

THE INTERPRETATION of arrhythmias on a 12-lead scalar electrocardiogram or on a monitoring strip can frequently be a difficult task. Essential to the interpretation is a good-quality stable baseline without artifacts. We are dependent on proper electrode placement, faultless technical assistance, and quality equipment. Unfortunately, artifacts are not uncommon in full 12-lead scalar ECGs because the equipment must fulfill American Heart Association standards of a wide frequency response range from 0.05 to 100 hertz. With this wide frequency range, the scalar ECG is subject to motion artifacts from respiration, arm movement, muscle tremors such as parkinsonism, and high-frequency electrical signals such as 60-Hz interference. Fortunately, bedside monitors are provided with a low- and high-frequency cutoff that eliminates most artifact. Our patient had a temporary transvenous pacemaker that caused an unusual ventricular pseudoarrhythmia during monitoring. This points out the need for caution in interpretation and treatment of a patient with an