tbuckley/cabot-search huggingface dataset:
The ubiquitin‐proteasome pathway and proteasome inhibitors
Authors: Jayhyuk Myung, Kyung Bo Kim, Craig M. Crews
Journal: Medicinal Research Reviews (2001)

The ubiquitin-proteasome pathway has emerged as a central player in the regulation of several diverse cellular processes. Here, we describe the important components of this complex biochemical machinery as well as several important cellular substrates targeted by this pathway and examples of human diseases resulting from defects in various components of the ubiquitin-proteasome pathway. In addition, this review covers the chemistry of synthetic and natural proteasome inhibitors, emphasizing their mode of actions toward the 20S proteasome. Given the importance of proteasome-mediated protein degradation in various intracellular processes, inhibitors of this pathway will continue to serve as both molecular probes of major cellular networks as well as potential therapeutic agents for various human diseases. © 2001 John Wiley & Sons, Inc. Med Res Rev, 21, No. 4, 245–273, 2001
DIETS AND FASTING IN EPILEPSY
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A life-saving maneuver to prevent food-choking
Authors: H. J. Heimlich
Journal: JAMA (1975)

EACH year, 3,900 healthy individuals in the United States strangle because of food stuck in their throats (<i>New York Times Magazine</i>, June 16, 1974, p 10). The actual incidence is probably much higher, as indicated by a report of unsuspected food-choking found at postmortem examinations of three patients thought to have died from myocardial infarction in one nursing home last year.<sup>1</sup>Food-choking is the sixth leading cause of accidental death—its victims number more than those accidentally killed by firearms or in airplane accidents. This article describes experimental studies and the clinical evaluation of a simple maneuver that prevents these food-choking fatalities. Food-choking can be recognized easily. The victim cannot speak or breathe; he becomes pale, then deeply cyanotic, and collapses. Because death is sudden (occurring in four to five minutes), the episode is sometimes confused with a myocardial infarction, although the signs and symptoms of the two are different. The
Changing Prescribing Practices Through Individual Continuing Education
Authors: Phil R. Manning
Journal: JAMA (1986)

In a study involving 94 practicing physicians, committees of clinical pharmacologists analyzed copies of prescriptions (and additional relevant clinical data) to identify problems in prescribing ("educational needs"). Only the ten most commonly prescribed drugs were studied in the samples of 200 prescriptions from each physician; 1061 problems were identified in the prescriptions of the 94 participants. One physician group (n=41) received feedback (instructional packets) addressing specific problems in prescribing; a second sample consisting of 200 prescriptions was then collected and analyzed. The physicians in this group changed their prescribing practices 30% of the time in accordance with recommendations, whereas those in the group that received no educational feedback changed in only 3% of the cases. When a physician stated an intention to change, an actual change resulted 50% of the time. Individualized teaching in response to real events in practice is a practical and effective method of improving physician performance. (<i>JAMA</i>1986;256:230-232)
An analysis of nonconfirmation rates. Experiences of a surgical second opinion program
Authors: M. Paris
Journal: JAMA (1979)

A review was conducted of the first 12 months' experience with a voluntary second opinion surgery consultation program. The program covers approximately 950,000 persons: employees of the city of New York, retirees, and their dependents. On a simple yes or no basis, the program's surgical nonconfirmation rate was 25%. More detailed analysis of consultants' narrative suggestions for patient care showed that a firm rejection of surgical intervention occurred in only 8% of the cases reviewed. Nonconfirmation rates were found to be unsatisfactory measures of program success in preventing potentially unnecessary surgery. Data from second surgical opinion programs should not be used to estimate the prevalence of unnecessary surgery in a community. The key benefit of such programs may be to facilitate and to encourage patient-physician communication. (<i>JAMA</i>242:2424-2427, 1979)
Effect of methoxsalen photochemotherapy on cost of treatment for psoriasis. An example of technological assessment
Authors: R. S. Stern
Journal: JAMA (1981)

In 1974 a new therapy that employs methoxsalen and ultraviolet A irradiation (PUVA) was introduced as an outpatient treatment for severe psoriasis. To study the effect of this therapy on the cost of treatment, we documented for 1,320 patients two major components of cost—hospitalization and PUVA treatments. When the one-year period before initiation of PUVA therapy was compared with a one-year period after initiation of PUVA therapy, average hospital days per person per year declined 77% (5.1 vs 1.2). This decrease in hospitalization was most notable among patients who continued to use PUVA therapy. Largely offsetting the reduction in cost from reduced hospitalization was the cost of PUVA treatments. Our data confirm the previously known effectiveness of PUVA therapy, and they provide no support for the hypothesis that PUVA substantially increases the cost of treating patients with severe psoriasis. (<i>JAMA</i>1981;245:1913-1918)
BRAZIL
Journal: JAMA (1960)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Kupffer cells generate superoxide anions and modulate reperfusion injury in rat livers after cold preservation
Authors: H Shibuya
Journal: Hepatology (1997)

This study was designed to determine the source of reactive oxygen species (ROS) and whether Kupffer cells modulate the injury of perfused rat liver after cold preservation. The livers of male Lewis rats pretreated with schizophyllan glucan (SPG) (10 mg/kg, SPG group) or gadolinium chloride (5 mg/kg; Gd group) and untreated rats (control group) were preserved in University of Wisconsin solution for 0, 12, and 24 hours at 4 degrees C and then perfused for 60 minutes with oxygenated Krebs-Henseleit bicarbonate buffer. Real-time chemiluminescence (CL) of the liver during perfusion was measured using a sensitive photomultiplier, and reperfusion injury was assessed by measuring lipid peroxidation and lactate dehydrogenase release. CL intensity reached a peak within 5 minutes of reperfusion, and superoxide dismutase completely inhibited this CL in all groups. In the control group, the total CL intensity was high after 24 hours of preservation. It significantly (P < .05 vs. control group) increased in the SPG group, while it decreased in the Gd group after 12 and 24 hours of preservation. The total CL intensity decreased by 70% (when diphenyliodonium chloride (100 micromol/L; an NADPH oxidase inhibitor) was added to the perfusate before preservation of untreated rats. Lipid peroxidation and lactate dehydrogenase release significantly (P < .05) deteriorated in the SPG group, while they ameliorated in the Gd group after 24 hours of preservation. These results demonstrate that Kupffer cells primarily generate superoxide anions and modulate the organ injury in the initial phase of reperfusion after cold preservation.
Differential Carcinogenic Effects of Intraperitoneal Initiation with 7,12-Dimethylbenz(a)anthracene or Urethane and Topical Promotion with 12-O-Tetradecanoylphorbol-13-Acetate in Skin and Internal Tissues of Female SENCAR and BALB/c Mice
Authors: Jerrold M. Ward, Sabine Rehm, Deborah Devor, Henry Hennings, Martin L. Wenk
Journal: Environmental Health Perspectives (1986)

Groups of female SENCAR or BALB/c mice were initiated once intraperitoneally with 300 micrograms/mouse of 7,12-dimethylbenz(a)anthracene (DMBA) or 20 mg/mouse of urethane at 7 weeks of age. Beginning one week later, mice received topically applied acetone or 12-O-tetradecanoylphorbol-13-acetate (TPA), once weekly, at 2.5 micrograms/mouse for weeks 1 through 6 and 1.25 micrograms/mouse for weeks 7 through 52. The skin lesions were evaluated clinically. A complete necropsy was performed on all mice at week 52. SENCAR mice exposed to DMBA/TPA and urethane/TPA had more skin tumors than SENCAR mice exposed to DMBA or urethane alone and more than BALB/c mice in any treatment group. Of all skin carcinomas diagnosed histologically in DMBA/TPA-exposed mice, less than one-third had been identified clinically while the mice were alive. Most of the carcinomas arose within papillomas. BALB/c mice developed more vascular and uterine tumors than did SENCAR mice injected with DMBA and more lung and vascular tumors than did SENCAR mice injected with urethane. TPA exposure after treatment with either initiator had no significant effect on internal tumor development in either SENCAR or BALB/c mice.
Contents
Authors: Zhichao Wu, Luke Saunders, Fábio Daga, Alberto Diniz-Filho, Felipe Medeiros, Alex Huang, Meng Li, Diya Yang, Huaizhou Wang, Ningli Wang, Robert Weinreb, Marco Lombardo, Daniela Giannini, Giuseppe Meng, Sebastiano Serrao
Journal: Ophthalmology (2017)
Corrections
Journal: American Journal of Psychiatry (2008)

When re-checking all information contained in supplementary table 5, the authors found and corrected errors in the map order for some haplotypes and most of the haplotype information (individual and global p-values, haplotype alleles for most associated haplotype, odds ratios).The authors also entered the data for the pre-existing columns of case and control haploype frequencies, added new columns for df for the global test and OR/95% confidence intervals, and expanded the footnote text for clarity.The revised cells are highlighted in yellow.None of the comparisons became statistically significant as a result of these corrections.This replacement table was uploaded on August 27, 2008.
The Challenge of Cancer to Our Community—a Conference
Journal: JNCI Journal of the National Cancer Institute (1986)

Journal Article The Challenge of Cancer to Our Community—a Conference Get access JNCI: Journal of the National Cancer Institute, Volume 77, Issue 3, September 1986, Page 835, https://doi.org/10.1093/jnci/77.3.835-b Published: 01 September 1986
Persistent neurological deficit precipitated by hot bath test in multiple sclerosis
Authors: J. R. Berger
Journal: JAMA (1983)

For a half century, the hot bath test has been used as a "diagnostic test" in multiple sclerosis. The appearance of new neurological signs or aggravation of preexisting signs generally is transient, with resolution on return of body temperature to normal. We have observed four patients, however, with considerable and prolonged neurological debilitation after hot bath testing. We suggest caution in the application of such testing. (<i>JAMA</i>1983;249:1751-1753)
Society Proceedings
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Acute bronchitis may predict future lung disease
Journal: BMJ (1998)

Tobacco will kill a third of the young men in China China now consumes a third of the world's cigarettes, and on pp 1411 and 1423 Liu et al and Niu et al report large nationwide retrospective and prospective studies of the hazards of tobacco, with closely concordant results.The pattern of disease caused by smoking varies widely from one part of China to another, and between China and the West, but the overall risk is substantial and growing.In Britain and America about half of all persistent cigarette smokers are eventually killed by tobacco, and about the same overall risks will be seen in China.Two thirds of the young men become persistent smokers, so about 100 million of the 0.3 billion Chinese men now aged 0-29 will be killed by tobacco in middle or old age.
Interferon in Polycythemia Vera (PV) Yields Improved Myelofibrosis-Free and Overall Survival
Authors: Ghaith Abu Zeinah, Spencer Krichevsky, Diana Jaber, Niamh Savage, Claudia Sosner, Gabriela Hoberman, Ellen K. Ritchie, Andrew I. Schafer, Joseph Scandura, Richard T. Silver
Journal: Blood (2019)
Medieval Psychiatry?
Authors: LeRoy P. Levitt
Journal: JAMA (1964)

<h3>To the Editor:—</h3> In the Question and Answer, "Transference of Responsibility" (<i>JAMA</i><b>188</b>:196 [April 13] 1964), an answer is given by Dr. Scher which should be seriously disputed. The problem concerned management of a 40-year-old woman who, despite considerable psychiatric care (of an unspecified nature), is still not able to function outside a protective setting. In the world, "she keeps very irregular hours, neglects her house and personal hygiene, and soon uses sedatives in dangerously large amounts." This scanty history provides little of the information so essential for diagnosis and management of such a severe emotional disruption of function. Dr. Scher advances a somewhat questionable and controversial answer, which, in essence, reflects an almost medieval concept, dwelling largely on the implication that this patient consciously is being manipulative and destructive to the people arourd her, and that "clear-cut responsibility demands" and "progressively enhanced realistic burdens" should be imposed upon
BOOK REVIEWS
Authors: J. J. MULVIHILL
Journal: JNCI Journal of the National Cancer Institute (1989)

BOOK REVIEWS Get access Long-Term Complications of Therapy for Cancer in Childhood and Adolescence. Daniel M. Green, ed. Baltimore: The Johns Hopkins University Press, 1989, 171 pp. $45. JOHN J. MULVIHILL JOHN J. MULVIHILL Clinical Epidemiology Branch, National Cancer Institute, Executive Plaza NorthRm. 400, Bethesda, MD 20892 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 81, Issue 21, 1 November 1989, Page 1664, https://doi.org/10.1093/jnci/81.21.1664 Published: 01 November 1989
Abstract 162: A Case of Fatal Kawasaki - Correlation Between Optical Coherence Tomography and Pathology
Authors: Audrey Dionne, Rose Chami, Geneviève Morissette, Nagib Dahdah
Journal: Circulation (2015)

Background: Coronary artery aneurysms (CAA) develop in up to 30% of untreated patients with Kawasaki disease (KD). This may lead to ischemic heart disease and sudden cardiac death, which is extremely rare nowadays. Method: A 3 mo infant presented with severe KD 27 days after onset of fever. He died few days later of multi vessel obstruction and aneurysms. OCT was performed post mortem and correlated with pathology findings. Results: The patient presented with shock, inferolateral ischemia on ECG and high Troponin-i (from 6.45 to 59 μg/L 2 days later). Echocardiography showed severe myocardial dysfunction with diffuse coronary dilation and right CAA. Arterial Doppler demonstrated thrombosis of aneurysmal axillary, subclavian and iliac arteries, which corroborated with clinically ischemic limbs. Withdrawal of support was implemented due to multiorgan failure. OCT images from the proximal RCA, LAD, carotid and pulmonary arteries were obtained post mortem. The circumflex coronary could not be accessed by the OCT catheter, which was occluded on pathology exam. The carotid (figure TOP) and pulmonary arteries were normal on OCT and histology. RCA and LAD (figure BOTTOM) showed aneurysmal dilatation, with marked intimal hyperplasia and preserved media on OCT. Pathology confirmed these findings, with destruction of internal elastic lamina, luminal myofibroblastic proliferation, neovascularization, and attenuation of the media in some sections. Conclusion: This is the first report of pathologic correlation in a severe KD case with OCT imaging at the sub-acute stage, which adequately identified structural wall changes.
Ulcerative Colitis: Report of Progress, Based on Recent Literature
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Growth hormone therapy for the elderly: the fountain of youth proves toxic
Authors: K. E. Yarasheski
Journal: JAMA (1993)

<h3>To the Editor.</h3> —We<sup>1</sup>and others<sup>2,3</sup>have proposed the use of recombinant human growth hormone (GH) therapy for the elderly in an attempt to retard the undesirable changes in muscle mass and function, body fat, and bone mineral content associated with advancing age, and the subsequent impact these have on health care costs. Our initial enthusiasm for this idea has declined as the result of an unexpectedly high incidence of side effects of GH therapy in this population. In 12 healthy older men (63 to 76 years of age) and two women (68 and 73 years of age) who received daily GH (12.5 γg/kg per day, n=12) or placebo injections (n=2) for 4 months to assess the effects of GH therapy on body composition and muscle strength, we have experienced a notable subject attrition rate related to symptoms of carpal tunnel compression, fluid retention, and arthralgia—complications not frequently
The Insane in Foreign Countries.
Journal: JAMA (1889)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MISCELLANEOUS.
Journal: JAMA (1884)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal