tbuckley/cabot-search huggingface dataset:
Abstract 2717: Role of NAD+ level by NQO1 enzymatic action in regulation of hair regrowth that prevents chemotherapy-induced alopecia
Authors: Dipendra Khadka, Gi-Su Oh, Hyung-Jin Kim, SeungHoon Lee, Su-bin Lee, Subham Sharma, Seon Young Kim, Tae Hwan Kwak, Sei-Hoon Yang, Hyuk Sim, Hong-Seob So
Journal: Cancer Research (2019)

Abstract Various types of chemotherapeutic agents are widely used to treat a variety of human neoplasms. Nonetheless, its clinical use is hampered because of severe adverse side effects such as alopecia, neutropenia, pain, cachexia, conception impairment etc. Chemotherapy-induced alopecia (CIA) is one of the fundamental unsolved problems of clinical oncology that often encountered in cancer treatment. CIA has been reported to be caused by skin inflammation through oxidative stress, DNA damage, and inflammatory responses. However, the best remedy for CIA is still not established. In a new strategy, we show that WK0202 compound as a strong NQO1 substrate that modulates the intracellular NAD+ levels by NAD(P)H quinone oxidoreductase 1 (NQO1) enzymatic action and plays important role in hair regrowth response to single (cyclophosphamide-CYP) or combined (taxol, adriamycin and cyclophosphamide-TAC) cancer therapy. Particularly, we demonstrated that cellular NAD+ levels as well as SIRT1 activity and its expression was decreased in skin with hair follicles after CYP and TAC treatment, and PARP-1 hyperactivation was associated with CIA through increased nuclear factor (NF)-κB p65 and p53 acetylation in wild type, NQO1-/- and K14-/- C57BL/6 mice. However, an increase in NAD+ levels by WK0202 completely restored SIRT1 activity and its expression, and subsequently deacetylated NF-κB p65 and p53 in wild type, however not in NQO1-/- and K14-/- mice thereby attenuating CIA. Therefore, modulation of NAD+ levels by NQO1 may be a novel therapeutic approach to prevent chemotherapy-associated hair loss, including CIA. Citation Format: Dipendra Khadka, Gi-Su Oh, Hyung-Jin Kim, SeungHoon Lee, Su-bin Lee, Subham Sharma, Seon Young Kim, Tae Hwan Kwak, Sei-Hoon Yang, Hyuk Sim, Hong-Seob So. Role of NAD+ level by NQO1 enzymatic action in regulation of hair regrowth that prevents chemotherapy-induced alopecia [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2717.
Self-determined death, the physician, and medical priorities. Is there time to talk?
Authors: E. D. Caine
Journal: JAMA (1993)

The bond between patient and doctor is frequently tested by life's challenges. It must be strong enough to buoy the patient until calmer times arrive, and should prove rewarding and renewing for both participants. Too many times, however, there is no bond or it has no substance beyond superficial convention. Patients admitted to acute care hospitals frequently do not know their physicians. In this era of entrepreneurial medicine, business principles are applied. Medicine and government together focus on productivity and "units of service." Rationing, benefit plans, and cost containment have taken center stage in the public arena. It is within this broad and unsettled context that the national debate regarding "rational suicide" and "physician-assisted suicide" has arisen. Whether people have the right to thoughtfully choose the time and means of their death, and what role physicians should play in the process are overlapping, but not identical issues. Ironically, they are
Cognitive Psychology of Missed Diagnoses
Authors: Donald A. Redelmeier
Journal: Annals of Internal Medicine (2005)

Letters21 June 2005Cognitive Psychology of Missed DiagnosesDonald A. Redelmeier, MDDonald A. Redelmeier, MDFrom the University of Toronto, Toronto, Ontario M4N 3M5, Canada.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-142-12_Part_1-200506210-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Dr. Derauf provides some insightful feedback in a kindly manner. His introduction of another maxim is particularly welcome, as are his remarks about the role of confidence in medicine. In moderation, confidence is necessary because facing trouble requires courage, the stakes in medical care are high, and clinicians do not want to act capriciously. Taken to extremes, however, any self-deception is a source of fallibility. A valid rationale is what distinguishes confidence from self-deception.Psychology research also shows that people sometimes are overly dependent on rationale. In one study (1), students were offered an attractive vacation following a ...Reference1. Tversky A, Shafir E. The disjunction effect in choice under uncertainty. Psychological Science. 1992;3:305-9. CrossrefGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From the University of Toronto, Toronto, Ontario M4N 3M5, Canada.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe Cognitive Psychology of Missed Diagnoses Donald A. Redelmeier Cognitive Psychology of Missed Diagnoses David D. Derauf Cognitive Psychology of Missed Diagnoses David D. Derauf Metrics Cited byAssessment of Immature Platelet Fraction in the Diagnosis of Wiskottâ€“Aldrich Syndrome 21 June 2005Volume 142, Issue 12_Part_1Page: 1026KeywordsCognitive psychologyConflicts of interestPsychology ePublished: 21 June 2005 Issue Published: 21 June 2005 Copyright & PermissionsCopyright © 2005 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
CODEINE ADDICTION
Authors: C M GRUBER, G M NELSON
Journal: Annals of Internal Medicine (1948)

Case Reports1 July 1948CODEINE ADDICTIONCHARLES M. GRUBER, Ph.D., M.D., GUY M. NELSON, M.D.CHARLES M. GRUBER, Ph.D., M.D.Search for more papers by this author, GUY M. NELSON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-29-1-151 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFor approximately 100 years codeine has been used in therapeutics with total disregard of its possible addicting properties. Since it has a feeble euphoric action the addiction liability is not great. The first case of true addiction to codeine was reported by Pelz1in 1905. The drug which had originally been given to this patient in 30 mg. (½ grain) doses three times a day for "nervousness" was gradually increased to 1.5 gm. (22½ grains) orally per day and ultimately to 3 gm. (45 grains). Treatment of this patient by the method of abrupt and complete withdrawal was followed by...Bibliography1. PELZ : Ein Beitrag zum Codeinesmus, Med. Wchnschr., 1905, xxxi, 864. Google Scholar2. SOLLIER P: Un cas de codeinomanie pure, Rev. de med. leg. et de jurisprud. med., 1913, xx, 359. Google Scholar3. HIMMELSBACH CK: Studies on codeine addiction, U. S. Pub. Health Rep. Supplement, 1940, No. 158, 2. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania*Received for publication April 5, 1947.From the Departments of Pharmacology and Medicine, Jefferson Medical College, Philadelphia, Pennsylvania. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPharmacokinetics and transplacental transfer of codeine and codeine metabolites from Papaver somniferum L.Identifying and treating codeine dependence: a systematic review 1 July 1948Volume 29, Issue 1Page: 151-153KeywordsAnxietyCodeineDrugsOpioid addictionPatientsPharmacology ePublished: 1 December 2008 Issue Published: 1 July 1948 PDF downloadLoading ...
Bronchopulmonary carcinosarcoma.
Authors: G Diaconita
Journal: Thorax (1975)

Carcinosarcoma accounted for 0.27% of nearly 3000 lung cancers examined in this department. All the patients were men aged between 44 and 62 years, and a majority of the tumours occurred in the left lung. Three patients died within six months of lung resection and in each case a postmortem examination was performed. In seven the carcinomatous component was a squamous-celled growth, and in one columnar-celled; the histology of the sarcomatous element varied. Carcinosarcomas form a distinct group of malignant lung tumours. In five cases sarcomatous transformation of the stroma had occurred and was considered to be the usual means by which the mixed type of growth arises. The other three were considered to be "collision" tumours. Carcinomatous metastases without sarcomatous change were seen in lymph nodes in three cases, and in three fatal cases sarcomatous tumour had recurred.
Social Engineering
Authors: Oliver C. Nickum
Journal: JAMA (1967)

<h3>To the Editor:—</h3> I hope the recent editorial headed "Preventi-Thought" (199:38, 1967) is the start of an intense campaign in the same vein to aid in reducing the activities of the so-called paramedical group, and to separate what is factual from the fantasies of the inexperienced in the care of the disabilities for which a course of medical studies is the only adequate preparation. My dues will be sent in soon for the 45th year, and I feel that I have always been able to measure value received for the membership, but the divide-andconquer group needs to have its responsibilities pointed out rather than to select its own goals. So many are inclined not only to outline what to do until the doctor gets there, but also to tell him what to do after he arrives. The moaning about the passing of the oldtime family doctor has already begun, but
PROPOSED ANNUAL SUMMARY OF DIPHTHERIA MORTALITY
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
HPV Vaccination Rates Lag in Teens
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
掌跖脓疱病患者中的斑片状银屑病
Authors: Y.M.F. Andersen, M. Augustin, J. Petersen, K. Hagenström, L. Mallbris, R. Burge, A. Egeberg
Journal: British Journal of Dermatology (2019)

美国、丹麦和德国开展的这项研究探讨了斑片状银屑病和掌跖脓疱病(PPP)共同发生的频率。斑片状银屑病是银屑病的最常见形式。PPP 是一种手掌和脚底上可看到充满脓液的斑点的疾病,通常在发红和鳞屑状皮肤上可见,如银屑病。PPP 与银屑病之间的关系(如果有)尚不明确。 从美国和德国保险记录以及丹麦国家患者登记处中,研究人员发现大约4000名被诊断患 PPP 的患者。 如本研究的评论所述,他们中的许多结果因不同国家而异。 例如,PPP 患病率从丹麦的 0.005% 到德国的 0.08% 不等。 PPP 患者中斑片状银屑病的患病率范围从丹麦患者的 14.2% 到德国的 36.4% 和美国的 61.3% 不等。 治疗方面,PPP 和斑片状银屑病患者更有可能被推荐使用强效类固醇药膏、软膏或凝胶,尤其是在美国和丹麦。在美国和丹麦,更多的同时患有这两种疾病的患者接受阿维 A 酸、甲氨蝶呤和生物制剂治疗,接受生物制剂治疗的比例差异很大:美国患者为 18.4%,而丹麦为 8.5%,德国为 2.5%。 与仅患 PPP 的患者相比,同时患 PPP 和斑片状银屑病的患者更有可能患与银屑病相关的关节疾病,这在所有三个国家中大致相同。
Mental Retardation
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
NOTICE TO OUR READERS.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Low incidence of treatment-related myelodysplastic syndrome (tMDS) and acute myelogenous leukemia (tAML) in patients with non-Hodgkin's lymphoma (NHL) treated with ibritumomab tiuxetan
Authors: C. Emmanouilides, M. S. Czuczman, S. Revell, T. E. Witzig, H. Wang, L. I. Gordon, B. Skikne, P. Foster, A. Molina
Journal: Journal of Clinical Oncology (2004)

6696 Introduction: 90Y Ibritumomab tiuxetan (Zevalin) radioimmunotherapy (RIT) was approved by the FDA in February 2002. RIT delivers high radiation dosage to tumors, and dose-limiting toxicity is hematological. Since tMDS/tAML has been associated with prior exposure to chemotherapy and radiation, we determined the incidence of tMDS/tAML in pts treated with ibritumomab tiuxetan from 4 registrational trials that have long-term follow-up. Results: In the 4 studies, 211 pts were treated with ibritumomab tiuxetan. These pts had received a median of 2 (range 1 - 9) prior treatments. With a median follow-up of 38 mos (range 1.2 - 75.5 mos), 7 pts (3.3%) have developed tMDS/tAML. Diagnosis of tMDS/tAML occurred 8 to 50 mos (median 18 mos) following therapy and 4.3 to 14 yrs (median 8 yrs) following the diagnosis of lymphoma. The annualized rates for the development of tMDS/tAML were 0.34% and 0.70% per yr from initial NHL diagnosis and from ibritumomab tiuxetan treatment date, respectively. This compares favorably to the published risk of tMDS/tAML in treated NHL pts of 1–1.5%/yr from 2 –10 yrs after initiation of therapy. Chromosome 5 and/or 7 abnormalities and/or deletions were detected in most pts, suggesting an association with prior alkylator-based therapy. In addition to the cases reported from the 4 registrational trials, there have been 5 cases of tMDS/tAML reported from 535 pts treated in an extended/compassionate use study (follow-up ranging from 0 - 36.5 mos). Two of these cases had documented abnormal baseline BM cytogenetic abnormalities prior to treatment with ibritumomab tiuxetan. Conclusions: Ongoing follow-up of pts from our registrational trials suggests that the annualized incidence of tMDS/tAML is consistent with that expected from this population of heavily treated NHL patients and does not appear to be increased following RIT with the ibritumomab tiuxetan therapeutic regimen. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Biogen Idec, Inc. IDEL IDEC; IDEL IDEC IDEL
IA. Medical Schools in the United States
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cervical Phimosis
Authors: P. M. Naidu, S. Ramaswamy, S. Krishna
Journal: BMJ (1964)

A series of 200 cases of kerosene ingestion is reviewed.Clinical and radiological findings suggest that the most significant complication is pulmonary damage following aspiration.Systemic effects of kerosene absorption appeared to be of little practical importance.A standard conservative regime of prophylactic penicillin, without gastric lavage, was employed.The mortality rate was 0.5%.A review of experimental reports and clinical findings indicate that treatment should be conservative, and that gastric lavage is contraindicated in the management of this condition.
Correction:<i>British Thoracic Society Winter Meeting 2019</i>
Journal: Thorax (2020)

Over a twelve-month period, one-third of referrals were diagnosed with IPF by the NILDS MDT consensus.One-third of patients with IPF were started on AFM.A disparity in the choice of AFM is evident with the majority of patients receiving Nintedanib for treatment of their IPF.The majority of patients are above the therapeutic threshold at the time of MDT review.Monitoring FVC at regular follow-up is therefore vital to ensure treatment initiation at earliest opportunity.
Reply
Authors: Andrew Blauvelt, Ana M. Duarte, Lawrence A. Schachner
Journal: Journal of the American Academy of Dermatology (1993)

of DPR.Several comparative tables have been published.8-10Naegeli-Francescetti-Jadassohn syndrome most closely resembles DPR, but one sees dental anomalies and a fading of the hyperpigmentation with age, neither of which have been reported with DPR.lO One difference between previous cases of DPR (including our case) and the case presented by Dr. Verbov is the "absence ofsweating problems."No quantitation of sweating was reported in Dr. Verbov's case.Itis possible that an asymptomatic mild hypohidrosis existed.This point emphasizes the need for quantifying sweating by an accepted method when these patients are examined, regardless of history.
Solving our primary care crisis by retraining specialists to gain specific primary care competencies
Authors: G. D. Lundberg
Journal: JAMA (1993)

That this country now has a full-blown crisis in its primary care physician work force is hardly disputed.<sup>1-3</sup>Simply stated, other developed industrial countries for many years have practiced medicine with roughly 50% of physicians in primary care and 50% in specialties and subspecialties.<sup>4</sup>In the United States, however, we train and employ about 32% primary care physicians (general practitioners, family physicians, general internists, general pediatricians, and some obstetrician-gynecologists and emergency medicine physicians) and about 68% specialists and subspecialists.<sup>4</sup>Health indicators show that comparison countries do as well as or better than the United States at providing care at much lower cost, whether cost is measured as the amount spent per capita per year or as a percentage of the gross national product. If that news isn't bad enough, the situation in the United States is rapidly getting worse. The percentage of physicians graduating from US medical
Les Lésions du Corps Thyroide dans la Maladie de Basedow.
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal