tbuckley/cabot-search huggingface dataset:
Fallibility of the clinical diagnosis of venous thrombosis
Authors: R. W. Barnes
Journal: JAMA (1975)

Doppler ultrasound examination confirmed the diagnosis of acute venous thrombosis in only 194 (37%) of 527 patients. Of the remaining 333 patients, 245 (74%) had some other evident cause of the limb complaints. The postphlebitic stasis syndrome; symptomatic varicose veins; congestive heart failure; leg trauma; venous or lymphatic obstruction by malignancy; cellulitis or lymphangitis; arthritis; and pregnancy were etiologic factors in these patients. The proved inaccuracy of the bedside diagnosis of leg vein thrombosis stresses the need for accurate objective verification of venous disease before committing the patient to a full course of anticoagulant therapy. For most clinicians, a contrast phlebogram is the most available and reliable diagnostic procedure. (<i>JAMA</i>234:605-607, 1975)
TETANUS TOXOID IMMUNIZATION
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Multistate Outbreak of Sporotrichosis in Seedling Handlers, 1988
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Thoracic Oncology
Authors: George E. Green
Journal: JAMA (1984)

Clinical management of chest tumors and the status of sciences relating to them are incisively documented in 21 chapters, which range from the epidemiology of lung cancer to surgery for pulmonary metastases. Experience with the established epidemic of lung cancer is presented in chapters addressed to epidemiology, pathology, radiological diagnosis, role and methods of pulmonary function assessment, and surgical therapy. Radiation biology, postoperative radiotherapy, and radiotherapy as a curative primary mode are exhaustively presented in separate chapters. The unique subject of pulmonary sulcus (Pancoast's) tumor is addressed in a special chapter. The writings on lung cancer conclude with chapters appraising aspirations and limitations of immunotherapy and chemotherapy. Tracheal neoplasms are described in two chapters—one focusing on pathology and one, by the foremost authority, Hermes Grillo, on surgical treatment. Management of cancer of the esophagus is evaluated in relation to surgery with or without radiation and, in a separate chapter on
Quarterly J Experimental Physiology, Edinburgh
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Proceedings of the Thoracic Society
Journal: Thorax (1964)

said that the mortality from un- treated congenital heart disease is high during the first year of life, so that in many instances operation, either palliative or curative, offers the only hope of survival.After the pioneering work of Boerema in Amsterdam on hyperbaric oxygen, animal experiments were performed at the Department of Surgery in Glasgow under Sir Charles Illingworth.Using a com- bination of hypothermia and hyperbaric oxygen at 2 atmospheres, the circulation was interrupted for periods of up to 30 minutes at approximately 25'C.This technique was applied to four infants who were very ill with congenital heart disease, so far without success.It may be possible in the future to combine hypothermia and hyperbaric oxygen at 3 or 4 atmospheres, thereby increasing the safe period of circulatory arrest.J. H. HUTCHISON considered that the urgent requirement of the severely asphyxiated newborn infant is that oxygen be introduced into the circulating blood as quickly as possible.Conservative measures, such as pharyngeal and nasal suction, facial oxygen, and stimulants, frequently fail to initiate respiration in such cases.Tracheal intubation and intermittent
Warnings: smokers opt for the new, prefer carbon monoxide poisoning to fetal injury
Authors: A. Blum
Journal: JAMA (1989)

<h3>In Reply. —</h3> There has been an encouraging show of support for the description of a smoke-free policy at the Minneapolis VA Medical Center, including letters from Drs Goldberg, Luck, and Prochazka. A number of hospitals have indicated that results from their surveys of patients and employees also demonstrate more support and less resistance to restricted smoking than anticipated. Patients, families, and visitors at the Minneapolis VA Medical Center continue to enjoy a clean indoor environment, despite a minority who disapprove of the smoke-free policy. Many inpatients who smoke are abstinent during hospitalization, which may contribute to permanent smoking cessation. The favorable response from other hospitals, in addition to our experience, suggests that the VA should consider a central directive to stop smoking in its hospitals and should help reduce the prevalence of this important and remediable risk factor for heart disease and cancer.
Hormone replacement therapy (HRT) in women with previously treated primary breast cancer: Update XIII
Authors: A. Z. Bluming
Journal: Journal of Clinical Oncology (2007)

11044 Background: To assess the incidence of contralateral or recurrent breast cancer among women prospectively treated with HRT after initial breast cancer diagnosis. Methods: A community-based, prospective, single-arm, pilot study of HRT among 246 women with previously treated primary breast cancer. Results: Median duration of HRT is 89+ months (range 12+ -173+). Median interval from initial surgery to initiation of HRT is 52 months (range 2–361 months). Follow-up to date is 100%. Actuarial disease-free survival (DFS), disease-specific survival (DSS), &amp; median duration of HRT by stage are listed in the table : *T0N0: 2 LCIS recurred locally after lumpectomy alone. 2 DCIS recurred locally after lumpectomy/RT 5 contralateral tumors (3 DCIS, 2 T1N0) 1 distant recurrence - liver. (alive 4 years later). **T1N0: 9 local recurrences after lumpectomy/RT 7 contralateral tumors. 8 distant recurrences - 3 lung, 2 liver, 3 bone - 4 died ***T2N0: 2 local recurrences after lumpectomy/RT 2 distant recurrences - lung - 1 died ****T1N1: 3 local recurrence after lumpectomy/RT 2 contralateral tumors 2 distant recurrences - 1 bone, 1 supraclav node - 2 died ***** T2–3N1: 1 contralateral tumor 3 distant recurrences - 1 cerv node-2 bone mets - 2 died One hundred and sixteen patients have stopped HRT (47%), 57 because of anxiety about taking HRT (23%), 50 because of breast cancer development (20%), 3 because of the development of non-breast cancers, 2 died of nonmalignant disease, 3 because of HRT-associated symptoms, and 1 because of pulmonary emboli without clinical phlebitis. CHRT, as opposed to ERT, was administered to 50% of all patients and 58% of the 50 who subsequently developed breast cancer on study. Actuarial DFS to 25 years for T1N0 patients was 67% versus 37% (DSS=86%) for comparable T1N0 patients who did not receive HRT. Conclusions: No evidence to date of increased development, recurrence or of breast cancer-related death associated with post diagnosis HRT. [Table: see text] No significant financial relationships to disclose.
Infant Feeding.
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
What’s in a name?
Authors: Mitchell J. Weiss, Philip J. Mason, Monica Bessler
Journal: Journal of Clinical Investigation (2012)

Mutations in numerous genes encoding ribosomal proteins (RPs) occur in 50%-70% of individuals with Diamond-Blackfan anemia (DBA), establishing the disease as a ribosomopathy. As described in this issue of JCI, Sankaran, Gazda, and colleagues used genome-wide exome sequencing to study DBA patients with no detectable mutations in RP genes. They identified two unrelated pedigrees in which the disease is associated with mutations in GATA1, which encodes an essential hematopoietic transcription factor with no known mechanistic links to ribosomes. These findings ignite an interesting and potentially emotional debate on how we define DBA and whether the term should be restricted to pure ribosomopathies. More generally, the work reflects the powerful knowledge and controversies arising from the deluge of data generated by new genetic technologies that are being used to analyze human diseases.
Medical News.
Journal: JAMA (1905)

<h3>ILLINOIS.</h3><h3>City Gives to Hospitals.</h3> —The city council of Joliet has appropriated $1,000 each to St. Joseph's and Silver Cross hospitals. <h3>Novel Way to Help Hospital.</h3> —J. W. Boice advertises that half of the proceeds of the auction sale of his farm implements and effects will be donated to the Rockford City Hospital. The sale was announced for March 21. <h3>In Favor of Defendant.</h3> —In the case of George Barnes who claimed that he had been permanently injured by treatment at the hands of Dr. William M. Roberts, Norris, and wanted damages, the jury found for the defendant. <h3>Silver Jubilee of Hospital.</h3> —On March 22, St. Joseph's Hospital, Bloomington, celebrated the completion of its first quarter century of work. Since its foundation the hospital has cared for 5,017 patients, 1,672 of which were charity cases. <h3>Personal.</h3> —Dr. Henry Hatch, Quincy, has been forced by ill health to give up his
The relationship of gonadal activity and chemotherapy-induced gonadal damage
Authors: S. A. Rivkees
Journal: JAMA (1988)

We tested the hypothesis that chemotherapy-induced gonadal damage is proportional to the degree of gonadal activity during treatment. Thirty studies that evaluated gonadal function after cyclophosphamide therapy for renal disease or combination chemotherapy for Hodgkin's disease or acute lymphocytic leukemia provided data for analysis. Data were stratified according to sex, illness, chemotherapeutic regimen and dose, and pubertal stage at the time of treatment. Chemotherapy-induced damage was more likely to occur in patients who were treated when sexually mature compared with those who were treated when prepubertal. Males were significantly more frequently affected than females when treated for renal disease or Hodgkin's disease. Chemotherapyinduced damage was also more likely to occur when patients were treated with large doses of alkylating agents. These data suggest that chemotherapyinduced damage is proportional to gonadal activity. Further efforts are needed to test whether induced gonadal quiescence during chemotherapy will reduce the strikingly high incidence of gonadal failure following chemotherapy. (<i>JAMA</i>1988;259:2123-2125)
Undescended Testis
Authors: None MD
Journal: JAMA (1996)

Q Left-sided inguinal exploratory surgery in a 5-year-old boy for a unilateral undescended testis demonstrated a normal vas deferens just beneath the external oblique fascia. The vas terminated in a 1.2-cm fibrous nodule located just outside the external ring. The nodule was excised, and histologic study showed portions of the vas deferens and hyalinized tissue with dystrophic calcification and without definable organoid structures. Now, 25 years later, the patient is healthy and has a normal testis palpable in the opposite side of the scrotum. Can it be assumed that the structure at the end of the vas was a maldeveloped testis? Is it possible that the actual testis remains undetected in the retroperitoneum, and therefore poses an increased risk for the development of a malignancy? If so, would imaging studies be helpful in searching for an undescended testis? <b>A</b>It has become unusual in the United States for boys with
Quality of care. Council on Medical Service
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE JOURNAL TRAIN.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Efficacy and safety of guselkumab in patients with psoriasis who have an inadequate response to ustekinumab: results of the randomized, double‐blind, phase III NAVIGATE trial
Authors: R.G. Langley, T.‐F. Tsai, S. Flavin, M. Song, B. Randazzo, Y. Wasfi, J. Jiang, S. Li, L. Puig
Journal: British Journal of Dermatology (2018)

Psoriasis is a chronic disease causing red and scaling skin lesions. Current treatments, especially biologics, which are either given by injection or intravenous infusion (IV), are very effective in the treatment of moderate to severe plaque psoriasis. However, most patients look to achieve clear skin, so there is room for improvement. One approved biologic, ustekinumab, blocks two of the body's internal proteins, interleukin (IL)‐12 and IL‐23. Blocking these proteins prevents signals that cause inflammation in psoriasis. While ustekinumab is effective in many patients, most will not achieve complete skin clearance. Because recent scientific evidence shows that IL‐23 may be more important than IL‐12 in causing psoriasis, guselkumab, a new treatment that specifically targets IL‐23, but not IL‐12, has been developed and was recently approved in the U.S. to treat moderate to severe psoriasis. In the NAVIGATE trial, 871 patients with moderate‐to‐severe plaque psoriasis received ustekinumab and if, after 16 weeks, patients were not clear or almost clear, they were randomly assigned to either continue ustekinumab or start treatment with guselkumab until week 44. From week 16 until week 40, the average number of visits (maximum = 4) at which patients were clear or almost clear was significantly greater in patients treated with guselkumab (1.5) than with ustekinumab (0.7). In addition, at week 28, twice the proportion of patients on guselkumab (31.1%) were clear or almost clear than on ustekinumab (14.3%). Infections were the most commonly reported adverse event among patients on either guselkumab or ustekinumab. The authors conclude that for patients who do not achieve clear or almost clear skin after ustekinumab treatment, switching to guselkumab could be an effective treatment strategy and did not raise safety concerns.
Ectopic Pregnancy
Authors: Paul F. Brenner
Journal: JAMA (1980)

Three hundred consecutive women with the surgical and histological diagnosis of ectopic pregnancy were studied to evaluate the etiological factors associated with this problem. Seventy-seven women had a history of surgical evidence of pelvic inflammatory disease (PID); 46 had a history of abdominal pelvic surgery; 32 had a history of both PID and surgery. Forty-three women had used an intrauterine device (IUD), and 32 had a device in utero at the time of the ectopic pregnancy. However, no definite relationship between use of the IUD and ectopic pregnancy could be established. A pregnancy test was positive in 207 of the 251 women on whom it was performed. Culdocentesis, performed on all patients, yielded nonclotting blood in 285 patients. Hematocrit value, measured on the culdocentesis specimen, was greater than 15% in 278 of the 285 women. (<i>JAMA</i>243:673-676, 1980)
Larazotide acetate reduces the frequency of bacterial translocation in the thioacetamide-induced liver failure in rats
Authors: Ali Riza Caliskan, Muhsin Murat Harputluoglu, Baris Otlu, Mehmet Gul, Elif Ozerol, Nuray Uremis, Ramazan Dertli, Murat Aladag, Ulvi Demirel, Jay Madan, Balasinghman Radhakrishnan
Journal: Journal of Hepatology (2020)
BABINSKI AND THE PLANTAR REFLEX
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal