tbuckley/cabot-search huggingface dataset:
Space-occupying gambits for medical writers
Authors: R. L. Reece
Journal: JAMA (1967)

Space-occupyingl writing like a fog. Yet the space-consuming efforts of many of us continue to be rejected. The message of this essay is that obscurity, when properly inflated, can lead to publication. Your goal is clear—to produce the greatest number of papers from the minimal amount of data using the maximal number of words. Before I describe the basic gambits, I will tell you how you should approach the game. Say nothing well and don't stop when you have said it. Remember that clarity is degrading, that blunt statements are impolite and that vagueness is safer than precision. Be aloof. Aloofness implies dignity, and dignity is a flexible weapon in the fight against clarity. If you want to become an artful practioner of turgid but publishable prose, master the following ten gambits. <h3>The Windfoggery Weave</h3> Windfoggery is the bedrock of all obscurity. Wind and fog do not coexist in nature
Medical specialization and world health needs
Authors: E. C. Long
Journal: JAMA (1971)

According to the 1966 data, there were some 15,000 foreign medical graduates in postgraduate training programs in the United States. Of those in residencies, 22% were in the field of surgery, 17% in internal medicine, 10% in pediatrics. Three percent were in general practice-type programs and 48% in other specialties. About 80% of these doctors came from countries in receipt of direct US Foreign Aid and which may be said to be "developing" rather than "developed." Other foreign medical graduates were studying in programs in Canada, Great Britain, France, Belgium, Scandinavia, and Israel. We should ask ourselves what the outcome of this level of activity is likely to be and what effects will come about when all these young doctors have completed their studies and if they return to their own countries. The subject is of double importance to the developing world because not only are the best medical graduates
THU0135 Comparison of Cardiovascular Disease Event Rates Among Patients with Rheumatoid Arthritis Across 10 Countries – Implications for CV Risk Assessment
Authors: None Atacc-RA Consortium
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Patients with rheumatoid arthritis (RA) have a well-established increased risk of cardiovascular disease (CVD). However, current CVD risk calculators for the general population (Framingham, SCORE, QRISK II and AHA/ACC) do not accurately predict CVD events in RA. <h3>Objectives</h3> We compared the predicted risk of a future CVD event to the CVD event rate in RA patients. <h3>Methods</h3> RA cohorts without prior CVD from 13 rheumatology centers were compared. CVD risk factors and RA characteristics were collected at baseline; CVD outcomes (myocardial infarction, angina, revascularization, CVD death, stroke and peripheral vascular disease) were collected prospectively. CVD risk was calculated for each patient based on baseline CVD risk factors and was converted to expected events. Poisson regression models provided standardized incidence ratios (SIR); observed to expected CVD. SIR&lt;1 means lower CVD events than predicted by risk calculators. <h3>Results</h3> 5685 RA patients without prior CVD were included (mean age: 55 [SD: 14] years, 76% female). During a mean follow-up of 6.1 years (31155 person years), 476 patients developed a CVD event. Two cohorts consisted of Hispanics, the rest Caucasians. RA disease duration varied by center: 4 with early RA (&lt;1 year), 7 established RA (mean 9-13 years) RA and 2 with both. CVD event rates varied across countries (range 0.1-1.9%/year) with the lowest observed in Canada, Mexico and UK and the highest in US, Netherlands, and Sweden. SIR varied greatly between centers for Framingham (0.22-1.32) and AHA/ACC (0.31-1.58) and to a lesser extent for SCORE (0.12-0.80) and QRISK (0.18-1.16). <h3>Conclusions</h3> Major heterogeneity exists in CVD event rates across different countries among patients with RA. Possible explanations include population differences, referral bias, RA treatment effects, statin and antihypertensive use. Generation of a CVD risk calculator that will be widely applicable for patients with RA must address these differences. <h3>Acknowledgements</h3> The ATACC-RA consortium: S Gabriel, C Crowson, E Matteson, G Kitas, K Douglas, A Sandoo, AG Semb, S Rollefstad, E Ikdahl, P van Riel, E Arts, J Fransen, S Rantapää-Dahlqvist, S Wållberg-Jonsson, L Innala, G Karpouzas, P Sfikakis, E Zampeli, P Dessein, L Tsang, MA Gonzalez-Gay, A Corrales, H El-Gabalawy, C Hitchon, V Pascual Ramos, I Contreras Yáñez, D Solomon, K Liao, M van de Laar, H Vonkeman, I Meek, E Husni, R Overman, I Colunga, D Galarza <h3>Disclosure of Interest</h3> None declared
Effect of Age and Diet on Renal Cadmium Retention in Rats
Authors: Krista Kostial
Journal: Environmental Health Perspectives (1984)

The results of our previous and recent work on cadmium metabolism in relation to age and diet are presented. Experiments were performed on albino rats aged 1-26 weeks. In some experiments rats were given different foods (milk, meat, bread) instead of standard rat diet. Some animals received trisodium calcium salt of diethylenetriaminepentaacetate (DTPA) intraperitoneally to decrease cadmium retention. Radioactive cadmium (115mCd) was administered orally and intraperitoneally. Whole body (WB), carcass (C) and organ (kidney, liver and brain) retentions were determined 1 and 2 weeks after a single radioisotope administration. The results are expressed as percentages of the administered dose (% D) and as percentages of whole body (% WB) and carcass (% C) radioactivities. After oral administration whole-body cadmium retention was higher in sucklings than in weaned animals, primarily due to increased gut retention. The kidney retention of orally administered cadmium was about 5-7 times higher in sucklings than in older rats. Cadmium distribution (% C) was similar after oral and intraperitoneal administration. In sucklings, kidney retention made a lower fraction of the carcass radioactivity one week after 115mCd administration but reached adult values a week later. Liver retention in sucklings was a slightly lower fraction of the carcass radioactivity than in older rats at both time intervals. Brain retention (% C) was about 10 times higher in sucklings than in older rats throughout the experiment. Preliminary data on the influence of dietary treatments and treatment with DTPA indicate that some treatments which influence cadmium retention also influence cadmium distribution.(ABSTRACT TRUNCATED AT 250 WORDS)
An Atlas of the Primary and Cutaneous Lesions of Acquired Syphilis in the Male.
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A RATHER DRASTIC SANITARY MEASURE.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Thrombomodulin inhibits intrahepatic spread in human hepatocellular carcinoma
Authors: T SUEHIRO
Journal: Hepatology (1995)

Thrombomodulin (TM) converts thrombin from procoagulant into anticoagulant protein to activate protein C. Thrombin also plays an important role in the metastatic process of cancer cells. We performed an immunohistochemical and clinicopathological study of TM in 141 cases with resected hepatocellular carcinoma (HCC) measuring less than 6 cm in diameter. Twenty-five specimens (17.73%) stained positive for TM. TM was found in the cytoplasm and surface of cancer cells. The clinicopathological findings according to the positive of TM are examined in HCC. The preoperative plasma TM level of the patients with tissue that stained positive for TM was significantly higher than that of the patients with negative results; for the postoperative TM level, there were no differences between them. In addition, the frequencies of intrahepatic metastasis, tumor thrombus in the portal vein, and capsular infiltration were significantly lower in patients whose tissue stained positive for TM than in patients whose tissue stained negative for TM. The recurrence freedom rate was significantly higher in patients whose tissue stained positive for TM than patients whose tissue stained negative for TM. Thus, TM-producing HCC shows a slow intrahepatic spread. Therefore, these findings suggest that TM may inhibit the adhesion of tumor cells to the portal vein because of anticoagulant activity and thus prevent the spread of intrahepatic metastasis.
Human Innate Lymphoid Cell Subsets Possess Tissue-Type Based Heterogeneity in Phenotype and Frequency
Authors: Yannick Simoni, Michael Fehlings, Henrik N. Kløverpris, Naomi McGovern, Si-Lin Koo, Chiew Yee Loh, Shawn Lim, Ayako Kurioka, Joannah R. Fergusson, Choong-Leong Tang, Ming Hian Kam, Koh Dennis, Tony Kiat Hon Lim, Alexander Chung Yaw Fui, Chan Weng Hoong, Jerry Kok Yen Chan, Maria Curotto de Lafaille, Sriram Narayanan, Sonia Baig, Muhammad Shabeer, Sue-Anne Ee Shiow Toh, Henry Kun Kiaang Tan, Rosslyn Anicete, Eng-Huat Tan, Angela Takano, Paul Klenerman, Alasdair Leslie, Daniel S.W. Tan, Iain Beehuat Tan, Florent Ginhoux, Evan W. Newell
Journal: Immunity (2018)
A phase II pilot trial of nivolumab (N) + albumin bound paclitaxel (AP) + paricalcitol (P) + cisplatin (C) + gemcitabine (G) (NAPPCG) in patients with previously untreated metastatic pancreatic ductal adenocarcinoma (PDAC).
Authors: Erkut Hasan Borazanci, Gayle S. Jameson, Mitesh J. Borad, Ramesh K. Ramanathan, Ronald Lee Korn, Lana Caldwell, Karen Ansaldo, Kristin Hendrickson, Katie Marceau, Daniel D. Von Hoff
Journal: Journal of Clinical Oncology (2018)

358 Background: Effective therapy for the treatment of PDAC remains one of the greatest unmet oncology clinical needs. The addition of C to G and AP has shown promising clinical data in a previously reported study [J Clin Oncol 35, 2017 (suppl 4S; abstract 341)]. In preclinical work, vitamin D (Vit D) analog therapy decreases myeloid derived suppressor cells and regulatory T cells, turning PDAC into a more immune-friendly microenvironment. This trial combines AP/C/G with Vit D analog P and the anti-PD-1 antibody N as a combination therapy for patients with previously untreated metastatic PDAC. This trial evaluates the efficacy and safety of NAPPCG in that patient population (NCT02754726). Methods: Eligibility criteria include Stage IV PDAC, no prior chemotherapy for systemic disease, KPS ≥ 70, and measurable disease. Doses are AP 125 mg/m 2 undiluted, G 1000 mg/m 2 in 250 ml of normal saline (NS), each infused over 30 minutes with C 25 mg/ m 2 in 500 ml of NS infused over 60 minutes on days 1, 8, 22, and 29 of a 42-day cycle. N is given at a fixed dose of 240 mg as a 60 minute infusion on days 1, 15, and 29. P is given at a fixed dose of 25 µg IV twice weekly. Primary objective is to determine the efficacy of the combination for patients with previously untreated metastatic PDAC through determining CR, ORR, PFS, and OS. The secondary objective is to evaluate safety in patients with previously untreated metastatic PDAC. Results: Trial was initiated May 2016 and10 patients have been enrolled in the initial phase of the study and are evaluable (baseline and ≥1 follow up CT scan). Most common drug-related grade (Gr) 3-4 adverse events (AE’s), n = 10, are thrombocytopenia 100% (gr 3 = 50%, gr 4 = 50%) with no serious bleeding events, anemia 50% (gr 3 = 50%, gr 4 = 0%), and colitis 20% (gr 3 = 20%, gr 4 = 0%). By RECIST 1.1 criteria, the best response is 8 PR and 2 SD, yielding an 80% ORR. Median PFS is 8.2 months. Median OS has not been reached. Conclusions: Although a small study, the high response rate is encouraging. This regimen is being expanded to 25 patients with plans to include exploratory inflammatory biomarkers. Clinical trial information: NCT02754726.
Comment on: Inhaled antimicrobial therapy—Barriers to effective treatment, by J. Weers, Inhaled antimicrobial therapy — Barriers to effective treatment, Adv. Drug Deliv. Rev. (2015), http://dx.doi.org/10.1016/j.addr.2014.08.013
Authors: David Cipolla, Juergen Froehlich, Igor Gonda
Journal: Advanced Drug Delivery Reviews (2015)
General Pathology
Authors: Lester S. King
Journal: JAMA (1966)

Undoubtedly, the<i>General Pathology</i>by Walter and Israel will take its place among the leading pathology texts. The new edition, appearing only two years after the first, has the usual changes which we expect in any new edition. There are some 110 additional pages, extensive revisions, additional illustrations, one new chapter, abundant new references, assistance in bringing chapters "up to date"—all these are the usual accompaniments of any new edition. The book can be highly recommended, and the statements made in the original review (<i>JAMA</i><b>188</b>: 474-475 [May 4], 1964) still apply. However, since frequent revisions and new editions are undoubtedly in prospect, we would exhort the authors not to deviate from their original intent. The first edition was of comfortable size, less than 900 pages of text. As the book grows in size, it will lose its value. Far better to limit the coverage, and to make that material
ABORTION
Authors: Virginia Clay Hamilton
Journal: JAMA (1941)

<h3>To the Editor:—</h3> An article in the June 21 issue ofThe Journal(Bush, W. L.: Tetanus Following Induced Abortion) high lights one of the great evils which should be attacked vigorously and specifically by the American Medical Association. I refer to the prevalence of abortionists and the<i>laissez-faire faire</i>attitude of the ethical members of our profession toward them. Five (or possibly seven) maternal deaths due to illegal abortions performed by one man in two weeks is indeed fortunately rare, but many times that number of fetal deaths and of potential maternal deaths are routine with numerous men whose existence in the community and even in the medical profession is tacitly condoned by the more respectable members of the latter. In the aggregate, the seriousness of this condition becomes apparent when one notes that 25 per cent of all maternal deaths occur in the first trimester of pregnancy and that
Fructose tolerance.
Authors: J A Black, K Simpson
Journal: BMJ (1967)

Acrylamide Poisoning-Garland and Patterson MBDICJOU months.With regard to the more severely poisoned, we are still in doubt whether complete recovery ever takes place.It is a relatively easy hazard to contain.Awareness of the severely toxic nature of the substance on the part of the manage- ment and workers is the principal factor in prevention of acrylamide poisoning.We wish first to thank the managements of the seven factories who allowed us to study their methods of using acrylamide.In particular we are grateful to those directors of factories making flocculators who unearthed cases among their own staff.They could so easily have behaved very much less helpfully.We thank Dr. J. C. Phemister for his permission to publish Case 1 and for his advice throughout on the neurological aspects.
Gene Transfer to Neurons Using Herpes Simplex Virus-Based Vectors
Authors: D. J. Fink
Journal: Annual Review of Neuroscience (1996)

Gene Transfer to Neurons Using Herpes Simplex Virus-Based Vectors, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/neuro/19/1/annurev.ne.19.030196.001405-1.gif
Assessing risks of rubella infection during pregnancy. A standardized approach
Authors: J. M. Mann
Journal: JAMA (1981)

Three algorithms have been prepared that should permit a rational and consistent assessment of the likelihood of acute rubella infection in the pregnant woman whose previous rubella immune status is unknown, and the attendant risks, if any, to her unborn child. (<i>JAMA</i>1981;245:1647-1652)
THE INTESTINAL ORIGIN OF PULMONARY TUBERCULOSIS.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effect of Proximal Vagotomy and Roux-en-Y Diversion on Gastric Emptying Kinetics in Asymptomatic Patients
Authors: J. L. URBAIN, F. PENNINCKX, J. A. SIEGEL, P. VANDENBORRE, E. VAN CUTSEM, V. VANDENMAEGDENBERGH, M. DE ROO
Journal: Clinical Nuclear Medicine (1990)

URBAIN, J. L. M.D.; PENNINCKX, F. M.D.; SIEGEL, J. A. PhD.; VANDENBORRE, P. M.D.; VAN CUTSEM, E. M.D.; VANDENMAEGDENBERGH, V. R.T.; DE ROO, M. M.D. Author Information
T-PLL-1 Protocol of the German CLL Study Group (GCLLSG) - A Prospective Phase II Trial of Fludarabine Phosphate, Mitoxantrone and Cyclophosphamide (FMC) Followed by Alemtuzumab Consolidation in T-PLL.
Authors: Georg Hopfinger, Raymonde Busch, Barbara Eichhorst, Gabriele Kandler, Clemens Wendtner, Michael Hallek
Journal: Blood (2005)
Congenital Mitral Stenosis With or Without Associated Defects
Authors: Alain Serraf, Joy Zoghbi, Emré Belli, François Lacour-Gayet, Hakim Aznag, Lucile Houyel, Virginie Lambert, Dominique Piot, Claude Planché
Journal: Circulation (2000)

Background —Congenital mitral stenosis (CMS) remains a surgical challenge, particularly when it is associated with other heart defects. As in other groups of heart defects, there is a trend toward early single-stage complete repair, but the optimal surgical approach remains unanswered. Methods and Results —This study was designed to analyze the evolution of surgical strategies in patients with CMS and associated defects through single-stage and staged repair. Between 1980 and 1999, 72 children were operated on for congenital heart defects, including CMS. Preoperative transmitral gradient was 12.6±7 mm Hg. Preoperatively, all the patients were NYHA class III to IV. Thirteen patients had an isolated CMS; in 59, it was associated with other heart defects, mainly ventricular septal defect (n=28) or multilevel left ventricular obstruction (n=41). In this group of patients, 33 had a staged approach, and 26 had a single-stage approach. Early mortality was 12.5% (9 patients). There were no deaths in the isolated CMS and single-stage repair groups. Logistic regression revealed that early mortality was influenced by association with left ventricular outflow tract obstruction ( P &lt;0.001) and by use of a staged approach ( P &lt;0.01). There was no late mortality in isolated CMS; there were 2 late deaths in the group of single-stage repair and 6 late deaths in the staged approach group ( P &lt;0.01). Reoperation was required in 24 patients, mainly for residual mitral valve dysfunction or residual left ventricular outflow tract obstruction. Including the reoperations, 10 patients received a prosthetic mitral valve. At 15 years after surgery, survival was 69.6±7.5%, freedom from reoperation was 70.8±6.3%, and freedom from mitral valve replacement was 69±6%. Conclusions —Surgery for isolated CMS gives excellent early and long-term results. In patients with associated heart defects, a single-stage operation seems superior to a staged approach. Mitral valve replacement in this category of patients should be reserved as a salvage procedure.
Varieties of consciousness
Authors: Paolo Bartolomeo, Gianfranco Dalla Barba
Journal: Behavioral and Brain Sciences (2002)

In agreement with some of the ideas expressed by Perruchet &amp; Vinter (P&amp;V), we believe that some phenomena hitherto attributed to “unconscious” processing may in fact reflect a fundamental distinction between direct and reflexive forms of consciousness. This dichotomy, developed by the phenomenological tradition, is substantiated by examples coming from experimental psychology and lesion neuropsychology.
RISK STRATIFICATION USING HIGH-SENSITIVITY CARDIAC TROPONIN T IN PATIENTS WITH SUSPECTED ACUTE CORONARY SYNDROME
Authors: Andrew R. Chapman, Dennis Sandeman, Amy Ferry, Stacey Stewart, Fiona E. Strachan, Ryan Wereski, Anda Bularga, Atul Anand, Anoop Shah, Nicholas L. Mills
Journal: Journal of the American College of Cardiology (2020)
The effects of the DRG-based prospective payment system on quality of care for hospitalized Medicare patients. An introduction to the series
Authors: K. L. Kahn
Journal: JAMA (1990)

In 1985, we began a 4-year evaluation of the effects of the diagnosis related groups—based prospective payment system on quality of care for hospitalized Medicare patients. This article provides an overview of the study's background, aims, design, and methods. We used a clinically detailed review of the medical record supplemented by data on postdischarge outcomes drawn from the files of the Health Care Financing Administration and fiscal intermediaries to (1) compare outcomes of care after adjustment for sickness at admission, (2) assess the process of in-hospital care and relationships between processes and outcomes, and (3) assess status at discharge for a nationally representative sample of patients hospitalized before and after prospective payment was implemented. (<i>JAMA</i>. 1990;264:1953-1955)