tbuckley/cabot-search huggingface dataset:
Contents
Authors: R Moreau, R Bataller, T Berg, J Zucman-Rossi, R Jalan, L Sua ´rez-, Amara ´n, C Usai, M Scala, C Godoy, Y Ni, M Hommel, L Palomo, V Segura, C Olagu, A Vales, A Ruiz-Ripa, M Buti, E Salido, J Prieto, S Urban, F Rodrı ´guez-Frias, R Aldabe, G Gonza ´lez-Aseguinolaza, S Susser, J Dietz, B Schlevogt, E Zuckerman, M Barak, V Piazzolla, A Howe, H Hinrichsen, S Passmann, R Daniel, M Cornberg, A Mangia, S Zeuzem, C Sarrazin, M Duriez, Y Mandouri, B Lekbaby, H Wang, A Schnuriger, F Redelsperger, C Guerrera, M Lefevre, V Fauveau, J Ahodantin, I Quetier, C Chhuon, S Gourari, A Boissonnas, U Gill, P Kennedy, N Debzi, D Sitterlin, M Maini, D Kremsdorf, P Soussan, F Poordad, D Nelson, J Feld, M Fried, H Wedemeyer, L Larsen, D Cohen, E Cohen, N Mobashery, F Tatsch, G Foster
Journal: Journal of Hepatology (2017)
THE ETIOLOGY OF DYSBASIA ANGIOSCLEROTICA.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Byssinosis in a Cotton Weaving Mill
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Postleukemic dysmyelopoiesis
Authors: Kathy Foucar, William P. Vaughan, James O. Armitage, Shivanand Patil, Fred Dick, Judith E. Karp
Journal: American Journal of Hematology (1983)

Abstract The morphologic and clinical features of four patients who developed significant bone marrow and blood dyspoiesis after successful chemotherapy for acute nonlymphocytic leukemia (ANLL) are described. This postleukemic dyspoiesis developed 1‐6 months after leukemia induction therapy and persisted for 5‐20 months in a relatively stable state. This period of prolonged dyspoiesis was not associated with rising myeloblast counts or clinical evidence of relapse. Dyspoietic abnormalities developed while two patients were receiving maintenance chemotherapy; the other two patients received no maintenance therapy. The dyspoietic changes in these four patients greatly exceeded those noted in a control group of ANLL patients on maintenance chemotherapy. The morphologic features of postleukemic dysmyelopoiesis were similar to those described in preleukemic dysmyelopoietic disorders. Erythroid abnormalities included hyperplasia with ring sideroblasts, megalobalstic changes, and cytoplasmic PAS reactivity. Myeloid abnormalities consisted of left‐shifted granulopoiesis with hyper‐ and hyposegmentation; megakaryocytic abnormalities included hyperplasia with a predominance of hypolobulated forms. Three of the four patients eventually suffered relapse and have died. The fourth patient died of sepsis after 20 months of pancytopenia and hysmyelopoiesis. Theories to explain the development of postleukemic dysmyelopoiesis are presented which emphasize the possibility of drug‐induced leukemia cell differentiation. Cytogenetic studies will be necessary to establish any relationship between ANLL and the subsequent postleukemic dysmyelopoiesis.
Lettsomian Lectures on the Ophthalmoscope and its Application
Authors: H. Walton
Journal: BMJ (1860)

IL371'7US (Th,u Wi, 1I.il teo sm ney, wih dams not ehlblt my indeaoff of bos tiue eng betwee the veseb and thetube.Hme and elsewhere, as I ha" show, the sehed and cumpled capillaries produce an appearane reembling fibrous tissue or matrix of tbe kidney (Arehitw of Medicine, No. m, 1858).This so.called matrix has ben oomtared to the ultimate ramifications of Glisson's capsule; and it has been considered
Auto Fumes Only One Cause of Smog in Los Angeles
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract O.18: Histopathological Analysis Of Sudden Death Adults With Coronary Artery Aneurysms
Authors: Kei Takahashi, Toshiaki Oharaseki, Yuki Yokouchi, Yasunori Enomoto, Kino Hayashi, Kumiko Asakura, Kazuyuki Saito, Aya Takada
Journal: Circulation (2015)

Histopathological study on coronary arterial lesions of adult autopsy cases who had a history of Kawasaki disease (KD) in childhood or who had coronary artery aneurysms (CAANs) was performed to analyze the relationship between post-inflammatory arterial lesions and atherosclerosis. Materials and Methods: Five autopsy cases who contracted KD at childhood and 11 autopsy cases who had giant CAANs at autopsy although a history of KD was not confirmed were included in this study. The age at death ranged from 18 to 57 years old. Forty-eight coronary artery (CA) branches from 16 autopsies were histologically examined focusing on the atherosclerosis which developed on the post-inflammatory lesions. Results: CAANs occurred in 30 arteries among 48 CA branches. CAANs were classified into 2 types; dilated CAANs (22 branches) and recanalized CAANs (8 branches). Dilated CAANs: The early atherosclerotic lesions, which corresponded to Type III or less of AHA classification, were seen in 16 CAs, and among them 6 branches had thrombotic luminal occlusion caused by the intimal erosion. On the other hand, the advanced atherosclerotic lesions corresponding to Type IV or more were observed in 6 of 22 branches and thrombotic occlusion of the lumen was observed in 5 of 6 CA branches. The cause of those thrombotic occlusion was estimated the rupture of atheroma. Recanalized CAANs: All atherosclerotic lesions developed in the recanalized CAANs were classified to the early lesions. Thrombotic occlusion was seen in 1 of 8 branches. Non-CAANs: There were 18 CAs with no aneurysm formation. The majority of Non-CAANs (16 of 18 branches) showed early atherosclerotic lesions (Type I or II), but 2 branches of 1 patient showed the advanced atherosclerotic lesion and the lumen was occluded by the fresh thrombus caused by intimal erosion. Conclusion: This histological study targeted at the post-inflammatory CA lesions in adult suggests two things: 1) Though advanced atherosclerotic lesions were often observed in the dilated CAANs, the atherosclerosis in the recanalized CAANs and Non-CAANs was still in early stage. 2) The erosion of the intima plays an important role in a formation of the thrombotic occlusion in the post-inflammatory arterial lesions even in adulthood.
Changes in rat liver gene expression induced by thioacetamide: Protective role of -adenosyl--methionine by a glutathione-dependent mechanism
Authors: M MESA
Journal: Hepatology (1996)

Chronic liver damage induced by thioacetamide (TAM) was accompanied by changes in the expression of genes related to growth (beta-actin) and function (albumin and haptoglobin) of the liver. Their messenger RNA (mRNA) levels increased during the first days after TAM administration, but 4 to 7 days after prolonged treatment with this drug, liver gene expression was considerable decreased. TAM-induced changes in albumin and beta-actin mRNA levels were prevented by cotreatment with S-adenosyl-L-methionine (SAM). We have investigated the possible involvement of glutathione in the protective mechanism of SAM. Firstly, we found that TAM treatment in the rat induced changes in liver glutathione disulfide (GSSG) levels, with a concomitant increase in the glutathione reductase enzymatic activity, these changes being abolished when animals were cotreated with TAM and SAM. Secondly, when rats were pretreated with buthionine sulfoximine (BSO), a glutathione synthesis inhibitor, before thioacetamide administration, the beneficial effect of SAM on liver gene expression was completely abolished. These results were confirmed by assaying the alanine transaminase serum activity, a parameter of liver injury. TAM-treated animals had increases in this serum enzyme, this effect being partially blocked by SAM. However, in BSO-pretreated rats, the protective effect of SAM was impaired. Taking together all these results, we propose a glutathione-dependent mechanism in the SAM protection against TAM hepatotoxicity in the rat. (Hepatology 1996 Mar;23(3):600-6)
Historical Archives
Authors: Helen Ollendorff-Curth, K Davies, P Yesudian, Ysbyty Clwyd, K Ollendorff-Curth, A Hamilton
Journal: British Journal of Dermatology (2014)

is a relatively unknown giant of dermatology.This eminent pioneer, who could have easily been lost to the persecution of Nazi Germany, does not even have a Wikipedia page!We describe her numerous achievements and contributions to dermatology.She was born in Breslau, Germany (now Wrocław, Poland), one of four children to Jewish parents.Helen's childhood was traumatic.Her father died before she reached her teenage years and a brother died after drinking a bottle of lye as a child.She later lost her sister during the First World War.Having survived this, Helen graduated from medical school in 1923.She worked with Josef Jadassohn in Breslau investigating the sensitivity of syphilitic skin lesions to a dull probe.The extreme sensitivity of papular lesions of secondary syphilis to touch was later known as the Ollendorff probe sign.This clinical feature is still used as an aid to diagnosing secondary syphilis.She received honours for this thesis at the beginning of what became a brilliant academic career.In 1924 she moved to Berlin under the guidance of Professor Abraham Buschke.They described Buschke-Ollendorff syndrome (in 1928), a rare hereditary disorder of connective tissue.She met her husband Wilhelm Curth during this period.In 1931 the Curths' lives changed.Returning from work by streetcar, Wilhelm witnessed a group of uniformed men board and remove anyone of Jewish appearance.The risk to his wife and child was overwhelming and he suggested that the family leave Germany.Unfortunately, Buschke was later arrested and died in a Nazi concentration camp.The Curths moved to New York, anglicized their names and began academic careers with Columbia University.Helen Curth's main areas of interest were acanthosis nigricans (AN) and disorders of keratinization.She published seminal papers on AN in peer-reviewed journals and contributed to Fitzpatrick's Dermatology in General Medicine.She formed criteria to diagnose paraneoplastic AN; to this day, they are called Curth's criteria.In 1954, with Madge Macklin, she reported a family affected by ichthyosis hystrix, which became known as Curth-Macklin ichthyosis.This made her the first woman to have eponymous syndromes in her maiden and married names.Curth-Macklin syndrome was the first named after two female physicians.Helen worked into her 70s.Tragically, she developed Alzheimer's dementia, and on her death in 1982 she donated her brain for research.She should be an inspiration to all dermatologists, present and future.
Developmental Toxicity of Ethylene Glycol Monopropyl Ether Acetate (EGPEA) in the Rat
Authors: Walter J. Krasavage, Gary V. Katz
Journal: Environmental Health Perspectives (1984)

Pregnant rats were exposed by inhalation to vapor concentrations of 100, 200, 400 or 800 ppm of ethylene glycol monopropyl ether acetate on days 6 through 15 of gestation. Concentrations of 400 and 800 ppm reduced the feed intake, mean body weight and red blood cell counts. Mean corpuscular volume and mean corpuscular hemoglobin were increased. Clinical signs of toxicity included lethargy and red discolored urine in the dams exposed to 400 or 800 ppm. The incidence of resorptions was significantly increased and the mean fetal body weight was reduced in litters of dams exposed to 800 ppm. Reproductive indices were not affected. Examinations at cesarean section revealed no major external malformations. Internal soft tissue examinations revealed three fetuses with a cardiovascular defect consisting of a right-sided aortic arch. Two of these fetuses were from dams exposed to 800 ppm, while the third was from a control litter. Skeletal examinations revealed no major skeletal malformations, while minor rib anomalies were slightly increased in litters from dams exposed to 400 or 800 ppm of ethylene glycol monopropyl ether acetate. The incidence of common skeletal variants was slightly increased at 200 ppm.
Captopril overdose resulting in hypotension
Authors: W. L. Augenstein
Journal: JAMA (1988)

We present a case in which a patient took an overdose of captopril (Capoten) and alprazolam (Xanax) in a suicide attempt. The patient presented with hypotension (systolic blood pressure of 80 mm Hg) and drowsiness. The hypotension initially responded to administration of intravenous fluids and dopamine; however, it recurred twice at 18.5 and 24.5 hours after ingestion. These episodes again responded to administration of fluids and dopamine. A plasma captopril level of 27 391.1 nmol/L (5982 ng/mL) was documented, as well as a depressed level of angiotensin converting enzyme. Captopril is an angiotensin converting enzyme inhibitor used in the management of hypertension and ventricular failure; to our knowledge, this is the first case of an acute captopril overdose reported in the English-language literature. The role of captopril in inducing hypotension is discussed herein. (<i>JAMA</i>1988;259:3302-3305)
Cost-effective Preoperative Laboratory Testing
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Permanent injunction order against AMA
Authors: S. Getzendanner
Journal: JAMA (1988)

The court conducted a lengthy trial of this case in May and June of 1987 and on August 27,1987, issued a 101 page opinion finding that the American Medical Association ("AMA") and its members participated in a conspiracy against chiropractors in violation of the nation's antitrust laws. Thereafter an opinion dated September 25, 1987 was substituted for the August 27,1987 opinion. The question now before the court is the form of injunctive relief that the court will order. See also p 83. As part of the injunctive relief to be ordered by the court against the AMA, the AMA shall be required to send a copy of this Permanent Injunction Order to each of its current members. The members of the AMA are bound by the terms of the Permanent Injunction Order if they act in concert with the AMA to violate the terms of the order. Accordingly, it is
Different gene expression in the breast after pregnancy
Authors: J. P. Janssens, I. Verlinden, N. Güngör, J. Raus, L. Michiels
Journal: Journal of Clinical Oncology (2004)

1019 Background: The protective effect of an early first full-term pregnancy (FFTP) in relation to breast cancer risk is well known, but the molecular and cell-specific mechanisms involved remain unclear. Methods: We analysed the global gene expression profiles of normal mammary tissues taken from a matched multiparous and nulliparous woman using Serial analysis of Gene Expression (SAGE) and Generation of longer cDNA fragments from SAGE tags for Gene Identification. Results: The differentiation markers such as caseinκ, caseinβ, keratin14 en CCAAT/enhancer binding protein β and δ are increased after pregnancy. Genes like bullous pemphigoïd antigen 1, decorin, vimentin, retinoid acid receptor responder, and the transcription factor early growth response 1 are also candidate markers for a pregnancy-induced differentiation. Histon deacetylase 2, Calpain, CAXII, collagen 1, osteonectin and connective tissue growth factor are decreased after pregnancy. Several of the genes that are lost after pregnancy encoded cytoskeletal and extra cellular matrix proteins. One of such genes, the small breast epithelial mucin (SBEM), consists most probably of a secreted sialoglycoprotein and may show a cancer-associated expression. SBEM is almost completely down regulated upon a FTTP but is expressed in 96 % of breast tumor cells. At least three tags corresponding to new genes show expression differences similar to SBEM. Conclusions: Our SAGE data found a different gene expression profile after pregnancy. Some of these genes might be useful in breast cancer risk assessment. No significant financial relationships to disclose.
Too Many Physicians Trained in Spain
Authors: X. Bosch
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Microplastics and human health—an urgent problem
Authors: None The Lancet Planetary Health
Journal: The Lancet Planetary Health (2017)

Microplastics come from many sources: synthetic clothing fibres, dust from tyres, road paints, and the breakdown of larger items. Orb Media's recent investigation has brought the issue of microplastics in the environment into sharp focus. The analysis of tap water samples from around the world found that a high proportion of drinking water is contaminated with microscopic fragments of plastic (83% of samples collected worldwide, but up to 94% in the USA). Microplastic contamination seems more widespread than we perhaps knew, and they are regularly being ingested by people worldwide.