tbuckley/cabot-search huggingface dataset:
Rationing human life
Authors: G. D. Lundberg
Journal: JAMA (1983)

What is a human life worth? Is each human life worth the same as every other? Or does the worth of a human life depend on the following: What country, state, county, or city a person lives in? The color of a person's skin, the language spoken, the person's age, gender, or sexual preference? Whether the person: Has an IQ of 150 or less than 50? Is a heart surgeon or a jaundiced newborn? Is a concert violinist or a victim of trisomy 21? Is a star professional quarterback or a quadriplegic? Is a millionaire or is on welfare? Is a mother of five young children or is a convicted rapist? Is a practicing psychologist or an institutionalized schizophrenic? Is a social worker or an active street heroin addict? Is a celebrated ethicist or a functional illiterate? Is primarily productive or primarily consumptive? These questions are being asked and choices
CORRECTION
Journal: JAMA (1969)

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Bridging the Gap
Authors: Jessica T. Lee, Melissa G. Lechner, Anand Vaidya, Maxwell Weinmann
Journal: New England Journal of Medicine (2019)

A 21-year-old man was found unresponsive in a park, with a 1-gallon container of green liquid, approximately half of it gone, nearby. The label was not legible, but the liquid was presumed to be antifreeze. The man was brought to the emergency department by ambulance. . . .
The 1941 Year Book of Public Health
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Renal Disease in Hypertensive Blacks: MRFIT
Authors: Donald R. Hoover
Journal: JAMA (1993)

<h3>To the Editor.</h3> —The article by Walker et al<sup>1</sup>is one of several studies to address the issue of the effect of blood pressure control on renal function and comparison of this effect in black and nonblack patients. Although their study has a large database (463 black and 5061 nonblack patients), it is unclear how many of the patients enrolled had preexisting renal disease. Their conclusion that blood pressure control was not efficacious in stabilizing or improving renal function in black patients may be due to the fact that more of the black patients in their study had underlying parenchymal renal disease than did the nonblack patients. The fact that there was no significant difference between average baseline serum creatinine level in the black and in the nonblack cohorts does not necessarily mean that there were equal proportions of patients with renal dysfunction in the two groups. In a
Neuropathology of Heavy Metal Intoxication
Authors: Martin R. Krigman
Journal: Environmental Health Perspectives (1978)

The basis for utilizing altered morphology, i.e., pathology, in defining diseases of the nervous system is presented. The importance of recognizing the dynamics of pathologic processes is emphasized, particularly in understanding the pathogenesis of neural diseases. Demonstrative examples of the neuropathology of human heavy metal toxicity are presented. The limitations of descriptive pathology are considered, and the potentials of quantitative (morphometric) analysis for studying pathologic processes are introduced.
In This Issue
Journal: Journal of Clinical Investigation (2009)

Hemangiomas Nox(4)ious requirementHemangiomas, benign endothelial cell-derived tumors, are the most common tumors of infancy.Previous studies indicated that the angiogenic cytokine angiopoietin 2 (Ang2) supports hemangioma growth.To investigate the molecular mechanisms underlying this, Bhandarkar and colleagues compared the ability of polyoma middle T-transformed brain endothelial (bEnd) cells derived from wild-type, Ang2 +/-, and Ang2 -/-mice to form hemangiomas in nude mice (2359-2365).Surprisingly, Ang2 +/-bEnd cells were greatly impaired in their ability to form tumors compared with either wildtype or Ang2 -/-bEnd cells.Although wild-type and Ang2 +/-bEnd cells formed slow-growing tumors resembling cavernous hemangiomas, Ang2 -/-bEnd cells generated fast-growing tumors resembling angiosarcomas rather than hemangiomas.Comparative gene array experiments performed in order to understand these differences revealed that NADPH oxidase 4 (Nox4) was markedly downregulated in Ang2 +/-versus Ang2 -/-bEnd cells.Knocking down Nox4 expression in an Ang2-sufficient bEnd cell line greatly impaired in vivo hemangioma growth, indicating the importance of Nox4 for hemangioma growth.Further analysis identified fulvene-5 as a potent in vitro inhibitor of Nox4, and the drug substantially inhibited in vivo hemangioma growth.The authors therefore conclude that Nox4 is crucial for hemangioma growth and suggest that targeting Nox4, potentially using fulvene derivatives, might provide a way to attenuate hemangioma growth.
Perinatal Mortality in Toxemia of Late Pregnancy, with Reference to Hypotensive Drugs
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Saying Goodbye
Authors: Danielle D. DeCourcey
Journal: JAMA Pediatrics (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Group A meningococcal carriage in travelers returning from Saudi Arabia
Authors: P. S. Moore
Journal: JAMA (1988)

In August 1987, an outbreak of group A meningococcal meningitis occurred during the annual pilgrimage to Mecca, Saudi Arabia, resulting in an attack rate among American pilgrims of 640 per 100 000. To determine risk factors for carriage, throat cultures were taken from passengers arriving on four consecutive flights from Saudi Arabia to the United States. Pilgrims were more likely to be group A meningococcal carriers than were nonpiligrims (relative risk, 11.1; 95% confidence interval, 3.7 to 33.1). Smoking, crowding, and meningococcal vaccination were not significantly associated with group A carriage. Pilgrims complaining of recent fever or sore throat, however, were more likely to be group A carriers, consistent with previous reports linking carriage and disease to preceding viral infections. Serogrouping of invasive meningococcal isolates can be used to monitor for indigenous transmission of this unusual strain in the United States, and we recommend routine vaccination of pilgrims to prevent future outbreaks of meningococcal disease. (<i>JAMA</i>1988;260:2686-2689)
An Index for Cancer Clustering
Authors: Toshiro Tango
Journal: Environmental Health Perspectives (1990)

This paper generalizes the index for temporal clustering proposed by Tango in two ways: it allows for nonuniform population distributions across the study period and it is applicable to the detection of disease clustering in space where there are variations in population distribution among categories of the confounding factor such as age and sex. Applications are illustrated with 1833 cases of mortality from uterine cancer in the Tokyo metropolitan area during 1978-1982.
Finding a better way
Authors: C. W. Walter
Journal: JAMA (1990)

THE CONCEPTUAL design of the Peter Bent Brigham Hospital, Boston, Mass, was that of a sanitorium, intended to provide the modes of therapy deemed crucial at the start of this century: quiet, space, and fresh, outdoor air. The wards for the indigent sick, constructed in 1911 through 1913, were pavilion style and spacious, with vaulted ceilings. High-volume air-conditioning mimicked the outdoors. The concrete floors under the beds were heated to provide radiant energy and warmth. Each ward had several wide doorways through which beds could be pushed onto porches. Some patients were so enchanted with the open air, they came indoors only for nursing care or during severe weather. The hospital buildings—10 in all by 1933 when I began my internship—were interconnected at ground level by 250 yd of covered walkway known as "the Pike." The southern exposure was open except where it was draped by gnarled wisteria vines. The
About-24-hours rhythms
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pseudo-Original Articles—The Case of Dr. Arthur E. Gue.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Foreword
Authors: R. H. Champion
Journal: British Journal of Dermatology (1978)

Journal Article Foreword Get access R. H. Champion R. H. Champion Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 99, Issue s16, 1 December 1978, Pages 1–3, https://doi.org/10.1111/j.1365-2133.1978.tb15198.x Published: 01 December 1978
Just Words
Authors: Alexander Gode
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Typhoid Hepatitis
Authors: B. H. KEAN
Journal: JAMA (1975)

<h3>To the Editor.—</h3> The article, "Typhoid Hepatitis," by Ramachandran et al (230:236, 1974) is another in the series creating confusion about the nature of hepatitis. Unhappily, the term is used to describe two different entities: focal lesions that may be seen in a single lobule or may be large enough to destroy several lobules, and diffuse lesions involving virtually all lobules. The focal lesions are seen in leprosy, tuberculosis, and amebiasis, and have clinical evidence of hepatic insufficiency only rarely. Examples par excellence of diffuse lesions are those seen in viral hepatitis and yellow fever. Amebic involvement of the liver is a focal lesion, single or multiple, small or large, and there is no such entity as diffuse amebic hepatitis. The lack of evidence for amebic hepatitis, presumably a diffuse lesion, has not prevented the publication of a series of articles describing it by Ramachandran and Doxiades. For two decades, Dr.
The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue
Authors: Lucia A. de Jesus, Suzy D. Carvalho, Mirian O. Ribeiro, Mark Schneider, Sung-Woo Kim, John W. Harney, P. Reed Larsen, Antonio C. Bianco
Journal: Journal of Clinical Investigation (2001)

Type 2 iodothyronine deiodinase (D2) is a selenoenzyme, the product of the recently cloned cAMP-dependent Dio2 gene, which increases 10- to 50-fold during cold stress only in brown adipose tissue (BAT). Here we report that despite a normal plasma 3,5,3′-triiodothyronine (T3) concentration, cold-exposed mice with targeted disruption of the Dio2 gene (Dio2–/–) become hypothermic due to impaired BAT thermogenesis and survive by compensatory shivering with consequent acute weight loss. This occurs despite normal basal mitochondrial uncoupling protein 1 (UCP1) concentration. In Dio2–/– brown adipocytes, the acute norepinephrine-, CL316,243-, or forskolin-induced increases in lipolysis, UCP1 mRNA, and O2 consumption are all reduced due to impaired cAMP generation. These hypothyroid-like abnormalities are completely reversed by a single injection of T3 14 hours earlier. Recent studies suggest that UCP1 is primarily dependent on thyroid hormone receptor β (TRβ) while the normal sympathetic response of brown adipocytes requires TRα. Intracellularly generated T3 may be required to saturate the TRα, which has an approximately fourfold lower T3-binding affinity than does TRβ. Thus, D2 is an essential component in the thyroid-sympathetic synergism required for thermal homeostasis in small mammals.
Dutch dispatch.
Authors: A Cats, F C Breedveld
Journal: Annals of the Rheumatic Diseases (1990)

Rheumatology in The Netherlands is under- going steady growth in both advancement of health care and in arthritis research.For many years the 'killing diseases' received most atten- tion in Dutch medicine.In recent years, how- ever, both from humanitarian and socioeconomic points of view, there has been a growing recognition of the need to stimulate educational and research programmes in the area of chronic disabling diseases.In this country rheumatology is a subspecialty of internal medicine, which requires a minimum of three years' training in general internal medicine and an additional three years' training in rheumatology before registration.The number of active rheumatologists has been increasing by an average of 5% a year since 1975.At the present time there are 100 registered rheumatologists in practice.Nearly all are active in general or teaching hospitals.With a national population of 14 million the Dutch Society for Rheumatology suggests the need for continued growth for some years.Last year a special report on arthritis care was presented to parliament.In addition, the Royal Academy of Sciences expressed its intention to stimulate research into rheumatic diseases.Despite these signs of official interest, however, it is the Dutch League against Rheumatism (J van de Rest, director) rather than the state which provides the major support for education, research, and other programmes in various fields of experimental and clinical work.The Dutch League against Rheumatism is one of the oldest of its kind.It was founded in 1926 by the perseverance of a pioneer in rheumatology, Dr Jan van Breemen.In addition to stimulating research and education in rheu- matology, the league furnishes educational materials, provides financial support, and sponsors recreational activities for patients with arthritis.Thanks to its support, which has increased continuously over the last five years to more than seven million guilders in 1989, rheumatology research has been able to maintain high standards.An example of the growing interest in rheu- matology is the recent institution of a fifth chair in rheumatology in the youngest of the Dutch Universities, Maastricht.Maastricht is a beauti- ful 2000 year old city along the river Maas in the most southern part of the country.This ambitious city, which aims at a role in future European activities, has now had a university for six years.
Alfred Fröhlich (1871-1953)
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal