tbuckley/cabot-search huggingface dataset:
Lack of relevance of the acetylator status on dapsone response in chronic autoimmune thrombocytopenic purpura
Authors: H. Le Louët, M. Ruivart, P. Bierling, J.C. Duche, B. Godeau
Journal: American Journal of Hematology (1999)

Dapsone provides an alternative treatment for patients with chronic autoimmune thrombocytopenic purpura (AITP) who had inadequate response to conventional therapy. However, the efficacy of this treatment is achieved in only 50% of patients. Dapsone is partly metabolized by the polymorphic N-acetyltransferase 2% and 50% of Caucasian patients show a genetically determined slow acetylator phenotype. The aim of our study was to investigate the influence of the acetylator status on dapsone efficacy in patients with chronic AITP. Nineteen caucasian adults with chronic AITP, previously treated by dapsone, were included in the study. Acetylator phenotype was determined by using a caffeine urinary test. Among the fourteen fast acetylator patients, eight patients exhibited positive response to dapsone and six patients did not. Among the five slow acetylator patients, one patient displayed a positive response to dapsone. Comparison of data by using the Fisher's exact test did not reach statistical significance. Our results do not support a relationship between dapsone efficacy and acetylator status in adults with chronic AITP. Am. J. Hematol. 62:251–252, 1999. © 1999 Wiley-Liss, Inc.
Cover Image, Volume 40, Issue 6
Authors: Mohd Farhan, Marta Silva, Shuai Li, Fengxia Yan, Jiankang Fang, Tangming Peng, Jim Hu, Ming‐Sound Tsao, Peter Little, Wenhua Zheng
Journal: Medicinal Research Reviews (2020)

The cover image is based on the Review Article The role of FOXOs and autophagy in cancer and metastasis-Implications in therapeutic development by Mohd Farhan et al., https://doi.org/10.1002/med.21695.
Effectiveness of adjuvant chemotherapy after radical nephroureterectomy for locally advanced and/or positive regional lymph node upper tract urothelial carcinoma.
Authors: Ross Erik Krasnow, Thomas Seisen, Joaquim Bellmunt, Morgan Roupret, Jeffrey J. Leow, Stuart R. Lipsitz, Malte Vetterlein, Mark A Preston, Nawar Hanna, Adam S. Kibel, Maxine Sun, Toni K. Choueiri, Quoc-Dien Trinh, Steven Lee Chang
Journal: Journal of Clinical Oncology (2017)

305 Background: There is limited evidence supporting the use of adjuvant chemotherapy (AC) after radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC). Against this backdrop, we hypothesized that such treatment is associated with an overall survival (OS) benefit in patients with locally advanced and/or positive regional lymph node disease. Methods: Within the National Cancer Data Base (2004-2012), we identified 3,253 individuals who received AC or observation after RNU for pT3/T4 and/or pN+ UTUC. Inverse probability of treatment weighting (IPTW)-adjusted Kaplan-Meier curves and Cox regression analyses were used to compare OS of patients in the two treatment groups. Additionally, we performed exploratory analyses of treatment effect according to age, gender, Charlson comorbidity index, pathological stage (pT3/T4N0, pT3/T4Nx and pTanyN+) and surgical margin status. Results: Overall, 762 (23.42%) and 2,491 (76.58%) patients with pT3/T4 and/or pN+ UTUC received AC and observation after RNU, respectively. IPTW-adjusted Kaplan-Meier curves showed that median OS was significantly longer for AC vs. observation (47.41 [IQR, 19.88-112.39] vs. 35.78 [IQR, 14.09-99.22] months; P&lt; 0.001). The 5-year IPTW-adjusted rates of OS for AC vs. observation were 43.90% vs. 35.85%, respectively. In IPTW-adjusted Cox regression analysis, AC was associated with a significant OS benefit (HR = 0.77; 95% CI = [0.68-0.88]; P&lt; 0.001). This benefit was consistent across all subgroups examined (all P&lt; 0.05) and no significant heterogeneity of treatment effect was observed (all P interaction &gt; 0.05). The 3-month conditional landmark IPTW-adjusted analysis demonstrated little impact of immortal time bias (HR = 0.79; 95% CI = [0.70-0.91]; P = 0.001). Conclusions: We report an OS benefit in patients who received AC vs. observation after RNU for pT3/T4 and/or pN+ UTUC. Although our results are limited by the usual biases related to the observational study design, we believe that the present findings should be considered when advising post-RNU management of advanced UTUC, pending level I evidence.
THE DIAGNOSIS OF ARTERIAL, MENINGEAL AND CEREBRAL DISEASE DUE TO SYPHILIS.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 3546: Cardiac Rehabilitation Improves Blood Flow in the Scarred Myocardium and Decreases Angiogenic Cytokines
Authors: Bai-chin Lee, Ssu-Yuan Chen, Wen-Yih I Tseng, Ming-Fong Chen, Yuan-Teh Lee
Journal: Circulation (2007)

Background Cardiac rehabilitation improves myocardial blood flow (MBF) in the patients with myocardial infarction (MI), but the mechanism is unclear. Angiogenic cytokines such as stromal-derived factor-1 (SDF-1), vascular endothelial growth factor (VEGF) and stem cell factor (SCF) could recruit circulating stem cells to improve tissue perfusion. We tested the hypothesis that plasma SDF-1, VEGF or SCF levels were association with MBF in the scarred myocardium in the post-MI patients undergoing cardiac rehabilitation. Methods and Results Thirty-nine patients were recruited, and 20 were randomly assigned to undergo a training program. Nineteen age- and sex- matched healthy subjects without any cardiovascular risk factors constituted the normal group. MBF, quantified with cardiac magnetic resonance by model-independent deconvolution methods, was assessed in the scarred myocardium at rest and at stress. Compared to the healthy subjects, peak oxygen uptake (VO 2 ) and MBF at stress, but not that at rest were lower; while SDF-1 and VEGF, but not SCF were higher in the post-MI patients. After 3 months, an increased MBF at stress (+30%, P &lt;0.01) and peak VO 2 (+15%, P =0.01) and decreased SDF-1 (−11%, P =0.01) and VEGF (−9%, P &lt;0.01) were seen in the training group, but not the MI control or normal group. The change in peak VO 2 correlated with the changes in MBF at stress and SDF-1 and VEGF ( r =0.48, −0.38, −0.40, respectively; all P &lt;0.05). Conclusions Cardiac rehabilitation improves myocardial blood flow in the scarred myocardium with a concomitant decrease in plasma angiogenic cytokines.
Conflicts of Interest
Authors: E. Haavi Morreim
Journal: JAMA (1989)

READERS of<i>JAMA</i>will not be startled to hear that the economic restructuring of medicine poses major moral and legal challenges. While most physicians have reconciled themselves, however uneasily, to prospective payment, aggressive utilization review, and preferred provider arrangements, many are deeply disturbed to find their own interests increasingly pitted against their patients'. First, many find themselves placed under incentives that reward or penalize them for their fiscal (im)prudence in ordering medical interventions for their patients. Second, physicians are investing as entrepreneurs in a burgeoning health care market. As researchers they may own stock in the same company that sponsors their investigations.<sup>2</sup>As clinicians they may invest in such health care enterprises as freestanding diagnostic imaging facilities, minor emergency centers, and home health care agencies (<i>The Wall Street Jounal</i>. March 1, 1989:A-1, A-6). Physicians make these investments for a variety of reasons. Payers' preference for an outpatient over an
Methaqualone abuse. "Luding out"
Authors: D. S. Inaba
Journal: JAMA (1973)

The "Love Drug," "Heroin for Lovers,"<sup>1,2</sup>"The Dr. Jekyll and Mr. Hyde Drug,"<sup>3</sup>"Hottest Drug on the Streets,"<sup>2</sup>"bigger than marihuana—methaqualone sweeping west."<sup>4</sup>With such grandiose publicity within the past few months, methaqualone, "pharmacologically equivalent"<sup>4</sup>to the short-and intermediate-acting barbiturates, has entered the emerging arena of desired (and commonly available) drugs of abuse. First introduced to the American public by William H. Rorer, Inc, in 1965 under the trade name of "Quaalude," it has at this writing become the sixth most popular sedativehypnotic in the United States, and in 1972 "Quaalude" sales alone increased 360%.<sup>1,2,3</sup>Motivated by such a success story many other drug companies have leaped into competition for this prosperous market and methaqualone is now marketed under the various trade names of Sopor (Arnar-Stone), Parest (Parke-Davis), Optimil (Wallace), and Somnafac (Smith, Miller &amp; Patch). The major selling point of methaqualone is that
Commentary
Authors: D Skelton
Journal: British Journal of Sports Medicine (2000)

Background-Tai Chi Chuan (TTC) exercise has beneficial eVects on the components of physical condition and can produce a substantial reduction in the risk of multiple falls.Previous studies have shown that short term TCC exercise did not improve the scores in the single leg stance test with eyes closed and the sit and reach test.There has apparently been no research into the eVects of TCC on total body rotation flexibility and heart rate responses at rest and after a three minute step test.Methods-In this cross sectional study, 28 male TCC practitioners with an average age of 67.5 years old and 13.2 years of TCC exercise experience were recruited to form the TCC group.Another 30 sedentary men aged 66.2 were selected to serve as the control group.Measurements included resting heart rate, left and right single leg stance with eyes closed, modified sit and reach test, total body rotation test (left and right), and a three minute step test.Results-Compared with the sedentary group, the TCC group had significantly better scores in resting heart rate, three minute step test heart rate, modified sit and reach, total body rotation test on both right and left side (p<0.01),and both right and left leg standing with eyes closed (p<0.05).According to the American Fitness Standards, the TCC group attained the 90th percentile rank for sit and reach and total body rotation test, right and left.Conclusion-Long term regular TCC exercise has favourable eVects on the promotion of balance control, flexibility, and cardiovascular fitness in older adults.
Corrections
Journal: BMJ (1966)

Any Questions ?BiRTisH sterilized at 130°C.for 30 minutes without appreciable decomposition.Samples so treated and stored at room temperature in the dark for three months showed only slight increases in peroxidized compounds and acidity and no increase in acetaldehyde.The authors pointed out that J. S. Toal2 had shown that some samples of paraldehyde decompose rapidly, especially when acidity is high, peroxidized compounds showing a very considerable increase.They concluded that the good keeping properties of their samples were probably due to the negligible presence of initial acid.They emphasized that paraldehyde for injection should be first examined by the B.P. method for impurities and only samples requiring less than 0.1 ml. of N/10 sodium hydroxide used-especially if the injection is to be stored for any time.The injection should be placed in ampoules, since it attacks rubber.This work suggests that ampoules of par- aldehyde should be stored in the dark in a cool place and used within three months.
Procedure
Authors: Carlos Rodriguez-Russo
Journal: Annals of Internal Medicine (2015)

Ad Libitum1 December 2015ProcedureCarlos Rodriguez-RussoCarlos Rodriguez-RussoFrom The Warren Alpert Medical School of Brown University, Providence, Rhode Island.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M15-1776 Audio Reading - “Procedure” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Procedure," by C. Rodriguez-Russo. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail We need to place a bloom of wiresunder the white awnings of her faceinto her neckbetween white curtains of hairunder white wrinklesTo better access her heart, of course.This is how I meet herSo she seems so frail, small,unwell—so she seems—Until she speaks to meAbout the fishher sons used to catch for hereach a different color;About the day years agothey brought her a yellowfin tunaso fresh and perfectshe could have never afforded it;so that she would remember even today... Author, Article, and Disclosure InformationAffiliations: From The Warren Alpert Medical School of Brown University, Providence, Rhode Island.Current Author Address: Carlos Rodriguez-Russo, The Warren Alpert Medical School of Brown University, 172 4th Street, Unit 1, Providence, RI 02906; e-mail, [email protected]edu. PreviousarticleNextarticle Advertisement Audio Reading - “Procedure” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Procedure," by C. Rodriguez-Russo. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 1 December 2015Volume 163, Issue 11Page: 883KeywordsHeartMeat ePublished: 1 December 2015 Issue Published: 1 December 2015 Copyright & PermissionsCopyright © 2015 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Ischemic heart disease mortality in Iowa farmers. The influence of life-style
Authors: P. R. Pomrehn
Journal: JAMA (1982)

Analysis of 62,000 deaths in Iowa men aged 20 to 64 years from 1964 to 1978 indicates that Iowa farm men younger than 65 years have lower than expected mortality for all causes and for ischemic heart disease. Using data gathered by the Iowa Lipid Research Clinics (LRC) Program Prevalence Study, we compared levels of known cardiovascular risk factors in farmers with those of nonfarmers residing in the same rural county. Farm men smoked less frequently (19%<i>v</i>44%) and engaged in exercise more frequently (83%<i>v</i>40%) than nonfarmers. Treadmill performance in farm men indicates a higher level of fitness in farmers. Farm people consumed more total calories and cholesterol, but drank less alcohol than nonfarmers. Farm men had significantly higher serum cholesterol levels. High-density lipoprotein cholesterol levels were also higher in farmers. However, when adjusted for age and exercise status, farmers and nonfarmers had similar lipid levels. The results of the LRC survey suggest that the lower mortality rates of Iowa farmers are a reflection of a life-style that includes vigorous exercise and little consumption of alcohol and tobacco. (<i>JAMA</i>1982;248:1073-1076)
Antimelanogenic peptides
Authors: J.H. Kim, J.K. Seok, Y.M. Kim, Y.C. Boo
Journal: British Journal of Dermatology (2019)

Melanin is the skin's natural colour, or pigment, and can be increased by aging, hormones, exposure to UV from sunlight, and inflammation caused by injury, burns, acne or allergies. Pigmentation disorders, such as hyperpigmentation, can cause irregular patches of darker skin, and although these disorders are not generally physically harmful, they can cause serious emotional distress. Peptides are increasingly being used in skincare products as active ingredients and antimelanogenic (anti melanin) peptides are potentially useful for the treatment of hyperpigmentation. Alpha‐melanocyte stimulating hormone (alpha‐MSH) is a peptide that, through a complex sequence of events, is involved in the synthesis ‐ or production ‐ of melanin. The authors of this study aimed to identify certain peptides that could inhibit this melanin synthesis that is triggered by alpha‐MSH. If these peptides could be targeted, it could stop the cascade of biological events that leads to the production of pigment in disorders like hyperpigmentation. In particular, glycinamide was found to inhibit melanin synthesis. The authors are currently conducting clinical trials on the safety and efficacy of these peptides, and anticipate a breakthrough in the treatment of skin pigmentation.
GRAHAM STEELL (1851-1942)— GRAHAM STEELL MURMUR
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Some Nutritional Aspects of a 3′-Methyl-4-dimethylaminoazobenzene-Induced Hepatoma In Vitro
Authors: McCoy, Thomas A., Maxwell, Merle
Journal: JNCI Journal of the National Cancer Institute (1959)

Journal Article Some Nutritional Aspects of a 3′-Methyl-4-dimethylaminoazobenzene-Induced Hepatoma In Vitro Get access Thomas A. McCoy, Thomas A. McCoy Biomedical Division, The Samuel Roberts Noble Foundation, Inc., Ardmore, Oklahoma Search for other works by this author on: Oxford Academic PubMed Google Scholar Merle Maxwell Merle Maxwell Biomedical Division, The Samuel Roberts Noble Foundation, Inc., Ardmore, Oklahoma Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 23, Issue 3, September 1959, Pages 385–393, https://doi.org/10.1093/jnci/23.3.385 Published: 01 September 1959 Article history Received: 09 February 1959 Published: 01 September 1959
Advances in Pediatrics. Volume V
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cigar Smoke Syncope
Authors: Mary Beth Miller
Journal: JAMA (1997)

<h3>To the Editor.</h3> —Although the prevalence of cigar smoking had been declining since 1970, recently it has increased with a US consumption of 4.5 billion cigars in 1996.<sup>1</sup>Cigar dinners are a "fashionable" forum in which cigar smoking is encouraged. In this report, we describe a patient who had a syncopal episode most likely attributable to the toxic effects of cigar smoke. <h3>Report of a Case.</h3> —A 61-year-old man was brought to the hospital by ambulance after a syncopal episode. He was at a crowded cigar dinner and had just finished smoking 2 cigars (Manifiesto Gran Reserva-Corona, 13.8 g; CAO-Robusto, 11.3 g). After beginning the third cigar (El Sublimato-Churchill), he developed light-headedness, diaphoresis, and nausea. He was in a confined space with a great deal of surrounding smoke and went outside the restaurant to "get fresh air." He lost consciousness (for approximately 12 minutes), only to reawaken in the
South African Medical Journal, Cape Town
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal