tbuckley/cabot-search huggingface dataset:
The Nail
Authors: Richard J. Smith
Journal: JAMA (1982)

A book devoted entirely to a study of the fingernails would appear to have achieved the ultimate in medical minutiae. Yet, reading<i>The Nail</i>, edited by Maurice Pierre, brings some happy surprises. In the first half of the book, we are reminded that, aside from the obvious aesthetic importance, changes in the nail and the nailbed may signal many systemic diseases such as cryoglobulinemia, cirrhosis, or porphyria. Nail changes may be an early sign of dermatologic disease such as psoriasis or lichen planus. Not infrequently, the nail and the nailbed may be the site of primary tumors such as melanoma or glomus. Several dozen sharp color plates beautifully demonstrate these pathological changes. It is a pity that the pictures are not a bit larger, but they can adequately serve as an excellent reference for the diagnostician puzzled by the clinical significance of a grooved, discolored, or misshapen fingernail. The second
Treatment of Severely Disturbed Children
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Blockade of LIGHT/LTβ and CD40 signaling induces allospecific T cell anergy, preventing graft-versus-host disease
Authors: Koji Tamada, Hideto Tamura, Dallas Flies, Yang-Xin Fu, Esteban Celis, Larry R. Pease, Bruce R. Blazar, Lieping Chen
Journal: Journal of Clinical Investigation (2002)

Previous studies have shown that blockade of LIGHT, a T cell costimulatory molecule belonging to the TNF superfamily, by soluble lymphotoxin β receptor-Ig (LTβR-Ig) inhibits the cytotoxic T lymphocyte (CTL) response to host antigenic disparities and ameliorates lethal graft-versus-host disease (GVHD) in a B6 to BDF1 mouse model.Here, we demonstrate that infusion of an mAb against CD40 ligand (CD40L) further increases the efficacy of LTβR-Ig, leading to complete prevention of GVHD.We further demonstrate that alloantigen-specific CTLs become anergic upon rapid expansion, and persist in the tolerized mice as a result of costimulatory blockade.Transfer of anergic CTLs to secondary F1 mice fails to induce GVHD despite the fact that anergic CTLs can be stimulated to proliferate in vitro by antigens and cytokines.Our study provides a potential new approach for the prevention of lethal GVHD.
THE HEMOLYMPH GLANDS IN PERNICIOUS ANEMIA.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Adrenal insufficiency following bilateral adrenal venography
Authors: R. T. Eagan
Journal: JAMA (1971)

Bilateral adrenal phlebography for the diagnostic study of hypertension led to prolonged severe bilateral flank pain. Adrenal insufficiency was unrecognized because its occurrence following adrenal phlebography had not previously been reported. Following discharge he became nauseated, weak, and severely hypotensive and responded only to hormonal replacement therapy. The patient subsequently failed to respond to corticotropin stimulation.
OBITUARY
Authors: William Morrant Baker
Journal: British Journal of Dermatology (1896)

Journal Article OBITUARY Get access William Morrant Baker, F.R.C.S. William Morrant Baker, F.R.C.S. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 8, Issue 12, 1 December 1896, Pages 489–490, https://doi.org/10.1111/j.1365-2133.1896.tb16895.x Published: 01 December 1896
Increased DC trafficking to lymph nodes and contact hypersensitivity in junctional adhesion molecule-A–deficient mice
Authors: Maria Rosaria Cera, Annalisa Del Prete, Annunciata Vecchi, Monica Corada, Ines Martin-Padura, Toshiyuki Motoike, Paolo Tonetti, Gianfranco Bazzoni, William Vermi, Francesca Gentili, Sergio Bernasconi, Thomas N. Sato, Alberto Mantovani, Elisabetta Dejana
Journal: Journal of Clinical Investigation (2004)

Junctional adhesion molecule-A (JAM-A) is a transmembrane adhesive protein expressed at endothelial junctions and in leukocytes. In the present work, we found that DCs also express JAM-A. To evaluate the biological relevance of this observation, Jam-A–/– mice were generated and the functional behavior of DCs in vitro and in vivo was studied. In vitro, Jam-A–/– DCs showed a selective increase in random motility and in the capacity to transmigrate across lymphatic endothelial cells. In vivo, Jam-A–/– mice showed enhanced DC migration to lymph nodes, which was not observed in mice with endothelium-restricted deficiency of the protein. Furthermore, increased DC migration to lymph nodes was associated with enhanced contact hypersensitivity (CHS). Adoptive transfer experiments showed that JAM-A–deficient DCs elicited increased CHS in Jam-A+/+ mice, further supporting the concept of a DC-specific effect. Thus, we identified here a novel, non-redundant role of JAM-A in controlling DC motility, trafficking to lymph nodes, and activation of specific immunity.
DANGERS OF CIGARET-SMOKING.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
OVARIAN CYST.
Authors: A. M. CARTLEDGE
Journal: JAMA (1897)

I desire to report a rather unique case. The woman from whom this cyst was removed was 37 years of age and lived in a hovel a great distance in the country. I saw her May 13 and operated the same day. The tumor had been growing for thirteen years, and for the last four years very rapidly, so that she was unable to assume the reclining posture for more than a year and a half. The circumference at the umbilicus was seventy-nine inches. The woman was five feet four inches in height and well formed, except that she was very much emaciated from carrying this enormous cyst. Twenty-four gallons of ovarian fluid were removed before she was placed in position to be anesthetized. After that she was placed on her back and ten additional gallons of fluid withdrawn. The adhesions to the anterior parietal wall were terrific. Many ligatures
Past, Present, and Future of Mutagens in Cooked Foods
Authors: Takashi Sugimura
Journal: Environmental Health Perspectives (1986)

Mutation assay with Salmonella typhimurium enabled us to detect various types of mutagens in cooked foods. A series of mutagenic heterocyclic amines has been isolated and identified in broiled fish and meat and in pyrolyzates of amino acids and proteins. Feeding experiments showed these mutagens to be carcinogenic in mice and rats. The mechanism of formation and pathway of metabolic activation of these heterocyclic amines have been elucidated. Their contents in various cooked foods have been determined. The presence of mutagenic nitropyrenes (some of which were confirmed as carcinogens) in grilled chicken was also established. Roasted coffee beans also yield mutagens such as methylglyoxal. The formation of mutagen precursors, including beta-carboline derivatives and tyramine which become mutagens with nitrite treatment, was found during food processing. Oncogene activation in animal tumors induced by some of these food mutagens/carcinogens has been confirmed. The role of mutagens/carcinogens in cooked foods in human cancer development has not yet been exactly evaluated. In order to do this, more information on their carcinogenic potency, human intake, metabolism in the human body, and the effects of combined administration with other initiators, promoters and other modifying factors in food is required.
The Relationship between Type of Alcoholic Drinks Consumed and Death from Various Causes
Journal: Annals of Internal Medicine (2000)

Summaries for Patients19 September 2000The Relationship between Type of Alcoholic Drinks Consumed and Death from Various CausesSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-133-6-200009190-00003 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Many studies have suggested that death rates are lower for people who drink low to moderate amounts of alcohol than for people who do not drink alcohol at all and those who drink heavily. However, studies have not been able to determine whether death rates differ for people who drink mostly beer, mostly wine, or mostly hard liquor.Why did the researchers do this particular study?To examine the relationship between types of alcoholic beverages consumed and death rates from heart disease, cancer, and all causes.Who was ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Type of Alcohol Consumed and Mortality from All Causes, Coronary Heart Disease, and Cancer.” It is in the 19 September 2000 issue of Annals of Internal Medicine (volume 133, pages 411-419). The authors are M Grønbæk, U Becker, D Johansen, A Gottschau, P Schnohr, HO Hein, G Jensen, and TIA Sørensen.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoType of Alcohol Consumed and Mortality from All Causes, Coronary Heart Disease, and Cancer Morten Grønbæk , Ulrik Becker , Ditte Johansen , Adam Gottschau , Peter Schnohr , Hans Ole Hein , Gorm Jensen , and Thorkild I.A. Sørensen Metrics 19 September 2000Volume 133, Issue 6Page: I-22KeywordsAlcoholicsAlcoholsCardiovascular therapyDeath ratesFactor analysisFoodHealth information technologyHealth surveysMortalityWine ePublished: 19 September 2000 Issue Published: 19 September 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
A physician's view of college sex
Authors: R. J. Collins
Journal: JAMA (1975)

SHE LOOKED like every other co-ed— long, straight hair, a sweatshirt too big, and dungarees too small. And her story was a familiar one. Her friends teased her about being a virgin so she had tried "it." Now, tearful and fearful, she described her symptoms. Examination showed only body lice— easily curable. Her reaction spoke volumes: "It sure wasn't worth it—it was no fun at the time, I've been worried ever since—and all it did was give me a dose of crabs." Ten years of listening to young women at a large Eastern university have made me aware of the sexual confusion of the children of a generation that either misunderstood or ignored sexuality and had little wisdom to pass on to its self-liberating children. Urged on by a loud minority, many young people have accepted a pattern of sexual activity that has no valid support. Anticipating love and happiness,
Abstract 36: <i>FCGR2A</i> Promoter Methylation and Risks for IVIG Unresponsiveness in Kawasaki Disease
Authors: Ho-Chang Kuo, Kai-Sheng Hsieh, Wei-Chiao Chang
Journal: Circulation (2015)

Kawasaki disease (KD) is characterized by pediatric systemic vasculitis of an unknown cause and the Fc Fragment of IgG, Low Affinity IIa, Receptor ( FCGR2A ) gene was reported to involve in increasing susceptibility of KD. Because DNA methylation is one of the epigenetic mechanisms that control gene expression, we hypothesized that methylation status of CpG islands in FCGR2A promoter predisposes an individual to Kawasaki disease. We recruited 36 KD patients and 24 healthy subjects with informed consents. And eleven potential methylation loci within the targeted promoter region (chr1:161474603-161475102) of Fc Fragment of IgG, Low Affinity IIa, Receptor were selected for investigation. Methylation at the CpG sites G, H and J displayed a strongly associations with KD, whereas CpG sites B,C,E,F,H,J and K were found to be correlated with non-responsive to IVIG treatment. In addition, CpG sites G, J and K were predicted as the significant transcription factor binding site for NF-kB, Myc-Max and SP2 respectively. Our study reports a significant association between the promoter methylation of FCGR2A , susceptibility of Kawasaki disease and therapeutic outcomes of IVIG treatment. The methylation levels of CpG sites of FCGR2A gene promoter may be an important marker for optimizing IVIG therapy.
Percutaneous Coronary Angioplasty in the Elderly: Impact on Functional Status and Quality of Life
Journal: Annals of Internal Medicine (2000)

Summaries for Patients20 June 2000Percutaneous Coronary Angioplasty in the Elderly: Impact on Functional Status and Quality of LifeSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-12-200006200-00045 SectionsAboutFull Text ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Coronary artery disease involves blockages in the blood vessels of the heart. Treatment for this disease includes medicines and more invasive treatments, such as bypass surgery or percutaneous revascularization. With percutaneous revascularization, doctors insert small balloons or tunnels (stents) attached to flexible tubes (catheters) into the large blood vessels in the patient's groin and thread them up into the heart. The stent and catheter are passed through the blocked vessels, a process that opens up the vessels. Older patients tend to have more complications from this procedure than ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Percutaneous Coronary Revascularization in Elderly Patients: Impact on Functional Status and Quality of Life.” It is in the 20 June 2000 issue of Annals of Internal Medicine (volume 132, pages 955-958). The authors are T.B. Seto, D.A. Taira, R. Berezin, M.S. Chauhan, D.E. Cutlip, K.K.L. Ho, R.E. Kuntz, and D.J. Cohen.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoPercutaneous Coronary Revascularization in Elderly Patients: Impact on Functional Status and Quality of Life Todd B. Seto , Deborah A. Taira , Ronna Berezin , Manish S. Chauhan , Donald E. Cutlip , Kalon K.L. Ho , Richard E. Kuntz , and David J. Cohen Metrics 20 June 2000Volume 132, Issue 12Page: 955KeywordsCathetersElderlyHeartPsychiatry and mental healthQuality of lifeQuestionnairesRevascularizationStable coronary artery diseaseStent implantationSurgery ePublished: 15 August 2000 Issue Published: 20 June 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.Loading ...
Primary prevention with metoprolol in patients with hypertension. Mortality results from the MAPHY study
Authors: J. Wikstrand
Journal: JAMA (1988)

The present study of primary prevention in white men aged 40 to 64 years attempts to investigate whether a β-blocker given as initial antihypertensive treatment would lower total mortality to a greater extent than thiazide diuretics. Patients were randomized to metoprolol (n = 1609, 8110 patient-years) or a thiazide diuretic (n = 1625, 8070 patient-years). The median follow-up time was 4.2 years. The mean dose of metoprolol was 174 mg/d, and of thiazide diuretics, 46 mg/d of hydrochlorothiazide or 4.4 mg/d of bendroflumethiazide. Identical control of blood pressure was achieved using a fixed therapeutic schedule. Total mortality was significantly lower for metoprolol than for thiazide diuretics because of fewer deaths from coronary heart disease and stroke. Total mortality was also significantly lower in smokers randomized to metoprolol. The benefit demonstrated in patients treated with metoprolol seems to have important implications for clinical practice. (<i>JAMA</i>1988;259:1976-1982)
Poison Control
Authors: Arthur J. McBay
Journal: New England Journal of Medicine (1967)

OVER eight thousand deaths per year are reported in the United States as due to poisoning. The actual number resulting from poisoning is a great deal higher than this figure. The discovery of a fatal case of poisoning depends on the quality of the medicolegal system involved in the investigation. In some jurisdictions, such cases are thoroughly studied, and, in others there is practically no investigation. The mere finding of a dead body with an empty drug container nearby is enough, without the benefit of autopsy or toxicologic analysis, to satisfy some investigators that poisoning was responsible.Statistics on cases . . .
Hydatid Disease: As Illustrated by Specimens Contained in the Pathological Museums of the Metropolis and in Others Elsewhere
Authors: T. S. Cobbold
Journal: BMJ (1875)

wvas here, unless, indeed, it aided in causing his inaptitude for exertion.Finally, there was no aphasia.Speech was low and mumbling, he was disinclined to converse, his replies were usually nearly mono yllabic; but, when urged, he could, and often would, speak more fully to the point, and used his limited vocabulary without hesitation or mis- take.The use of language was partly restricted by his mental condition; the impairment of articulation was merely of a paretic nature, and the essential characters of aphasia proper were absent.
ESGE News and Upcoming Events January 2019
Journal: Endoscopy (2018)

Looking back, 2018 was an excellent year for ESGE. The launch of our first congress, ESGE Days 2018, was a landmark for our society. The 1,400 participants who came together in Budapest experienced an extensive programme dedicated solely to endoscopy. The enthusiastic reception reinforced ESGE’s decision to hold this new congress every year. We look forward to welcoming you to ESGE Days 2019, April 4 – 6 in Prague where we are expecting more than double the amount of participants.
THE HYGIENE OF WAR.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal