tbuckley/cabot-search huggingface dataset:
Prevalence, kinetics, and therapeutic modulation of autoantibodies against Sp100 and promyelocytic leukemia protein in a large cohort of patients with primary biliary cirrhosis.
Authors: D Züchner
Journal: Hepatology (1997)

Antinuclear antibodies (ANA) staining nuclear dot structures predominantly occur in primary biliary cirrhosis (PBC) patients and recognize the Sp100 and promyelocytic leukemia protein (PML). From retrospective analysis of sera from a clinically well-defined Canadian series of 170 PBC patients included into a 24-month therapeutic trial of ursodeoxycholic acid (UDCA), we report the prevalence of these ANA and their dynamics in the course of the disease. Using an enzyme-linked immunosorbent assay (ELISA), anti-Sp100 autoantibodies were shown in 35 (21%) patients. Thirty-three patients (19%) had autoantibodies against PML as determined by indirect immunostaining of cells overexpressing PML. Altogether, anti-nuclear dot autoantibodies were present in 25% of the 170 PBC patients. Their occurrence correlated with an unfavorable disease course, because these patients progressed significantly more frequently from early stages (I/II) to late stages (III/IV) within the 24-month observation period (P < .05). During the course of the disease, the autoantibody levels against the Sp100 full-length protein remained nearly constant in all 35 positive patients. However, 9 patients showed remarkable changes in Sp100 epitope recognition as revealed by ELISA and immunoblotting. When the occurrence of these changes and the treatment of the patients were compared retrospectively, it became evident that 8 of the 9 patients had received UDCA (42% of all Sp100-positive patients treated with UDCA). These findings indicate subtle changes of the Sp100 epitope recognition pattern during the natural course of the disease and its induction or acceleration by UDCA treatment. This implies that UDCA can modulate immunoglobulin (Ig) expression not only quantitatively, but also qualitatively. (Hepatology 1997 Nov;26(5):1123-30)
Experimental Aqueous Perfusion in Enucleated Human Eyes
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Computers in medicine
Authors: D. A. Lindberg
Journal: JAMA (1995)

Since previous Contempo reports on computers in medicine in 1989 and 1990, computing systems and devices have been incorporated into medical practice at an accelerating rate. The influence of computing can be seen in diagnostic imaging systems, radiation therapy, the intensive care unit, the clinical laboratory, and the business office. Planning for institution-wide advanced information management systems has become more sophisticated and widespread.<sup>1</sup>The American Medical Informatics Association has been formed as a forum for open scientific meetings and education in the field of medical informatics. Virtually every US academic medical center and many hospitals have on-line or CD-ROM systems that allow individual health professionals and students to search MEDLINE and other databases for themselves. A rapidly growing group of institutions and individuals use Internet connections to reach information sources and to transmit and receive the full text of documents.<sup>2</sup>Many physician "end-users" search databases from home or
Medical Education.
Authors: Bayard Holmes
Journal: JAMA (1900)

To the Editor:\p=m-\Thevery comprehensive and elegant edi- torial on "Medical Education," in The Journal of January 27, must commend itself, on the whole, to every teacher of medicine.It is a startling, if not disgraceful, fact that we have, during the past twenty years, seen the army of specialists grow, while the regular practicing physician has sunk into corresponding insignificance or obscurity.It is now the ambition of far too many medical students to become specialists in one department or another, where they can practice medicine "handsome and out of the wet."From the standpoint of the schoolmaster, however, there are a few assumptions in the editorial which might lead to errone- ous conclusions.In the first place it is a mistake to assume that any American medical school proposes, or ever proposed, to put the student of medicine to the serious work of original medical research and investigation.Doubtless this erroneous assumption comes from the fact that it has been proposed, and successfully tried, to put the student in the position of an ob¬ server and investigator, and in this manner to teach him the elements and facts of medical science in an unforgetable man¬ ner.
Things as They Are
Authors: John Dillon
Journal: JAMA (1965)

<h3>To the Editor:—</h3> I enjoyed "Things as They Are" (<i>JAMA</i><b>190</b>:997 [Dec 14] 1964) and I write not to decry modern anesthesia but to keep part of the record straight. It is not correct that "literally nothing was known about anesthesia" before World War II. Most of today's neurological, thyroid, lung, heart, abdominal, gynecologic, obstetric, and orthopedic operations were done with skillful anesthesia decades before World War II. In fact, Souttar's very successful mitral-valve operation on May 16, 1925, trailed all the other types of operative procedures named. We of 40 years ago had theories and assumptions regarding anesthesia founded on the shifting sands of physiology and pharmacology. The absolutes unknown then are unknown now, but new answers to the same old unanswerable questions have come and gone. A very important and often neglected study in any profession is its history. Things as they were: Yesterday's surgery was more
Iris pigmented lesions as a marker of cutaneous melanoma risk: an Australian case-control study
Authors: A.M. Laino, E.G. Berry, K. Jagirdar, K.J. Lee, D.L. Duffy, H.P. Soyer, R.A. Sturm
Journal: British Journal of Dermatology (2018)

Early diagnosis of melanoma of the skin leads to a higher chance of successful treatment and survival. Clinicians need to be aware of patients at high risk, such as those with multiple naevi (moles) to enable early detection of melanoma. Pigmented naevi and freckle‐like lesions (spots) are common in the iris, which is the coloured part of the eye around the pupil. It is known that pigmented iris lesions are associated with dysplastic skin naevi, meaning moles that are abnormal‐looking but not cancerous, but a link with melanoma has not been confirmed. The authors, mostly based in Brisbane, Australia, aimed to determine if iris pigmented lesions were a risk factor for melanoma. They examined and took digital eye photographs of 1117 dermatology patients who had been diagnosed with melanoma, and control subjects (without melanoma). They found that there was a 45% increased incidence of melanoma in patients under 40 who had three or more iris pigmented lesions; this was in addition to other risk factors for melanoma. They concluded that multiple areas of iris pigmentation were a risk factor for melanoma in people of European origin.
Purification of circulating liver plasma membrane fragments using a monoclonal antileucine aminopeptidase antibody
Authors: J DENG
Journal: Hepatology (1996)

Membrane-bound liver alkaline phosphatase (Mem-LiALP, EC 3.1.3.1) is a high-molecular-mass liver alkaline phosphatase (ALP) present in metastatic, infiltrative and cholestatic liver disease. Shedding of hepatocyte plasma membrane fragments (LiPMF) is thought to be responsible for the appearance of Mem-LiALP in the circulation. Several other membrane-bound enzymes, such as γ-glutamyltransferase (γ-GT), leucine aminopeptidase (LAP), and 5′-nucleotidase (5′-Nu) are present in the membrane of the shedded LiPMF. By means of immunohistochemical and immunoassay procedures, we presently show that AD-1, a specific monoclonal antibody originally produced against Mem-LiALP, reacts with LAP, a constituent of the human liver plasma membrane. Using AD-1 as an immunosorbant, we isolated circulating LiPMF from cholestatic sera to a high level of purity and separated it from other high-molecular-mass material, such as liver ALP ∼ lipoprotein-X complexes. These purified membrane fragments retained their biochemical characteristics. Glycosyl-phosphatidylinositol anchor bearing liver ALP (Anch-LiALP) could be released from the LiPMF by Triton X-100. Whereas ALP was released upon treatment of AD-1 purified LiPMF with phospholipase C, phospholipase D only cleaved the glycosyl-phosphatidylinositol anchor following detergent solubilization of the enzyme. Serum LiPMF from patients with different kinds of cholestatic liver disease were bound onto AD-1 coated nitrocellulose disks and the activity of four membrane-bound enzymes (LAP, ALP, 5′Nu, γ-GT) was analyzed. A considerable interindividual variation of enzyme activities was observed, suggesting some heterogeneity in the membrane composition of these fragments.
Transluminal iliac artery dilatation. Nonsurgical catheter treatment of atheromatous narrowing
Authors: C. T. Dotter
Journal: JAMA (1974)

By means of a reinforced balloon catheter, percutaneous transluminal dilatation was used to treat 48 consecutive cases of atheromatous iliac artery narrowing. With no deaths and little increase in the time and risk of diagnostic arteriography, the procedure was successful in more than 80% of cases, giving immediate luminal enlargement and relief, as judged clinically, for up to six years, the maximum follow-up period. In properly selected patients, this technique should be used in preference to reconstructive vascular surgery. (<i>JAMA</i>230:117-124, 1974)
GLAZES AND ENAMELS OF COOKING UTENSILS
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Consultants for The Journal in 1968
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Congenital heart disease in an asymptomatic 29-year-old woman
Authors: G. C. Jang
Journal: JAMA (1970)

Dr. S. Boyd Eaton: This patient, a 29-year-old white woman, had been known to have an asymptomatic heart murmur since birth. At the ages of 16 years and 19 years, she had subacute bacterial endocarditis which required hospitalization. In recent years, the patient has complained of easy fatigability, some chest pain, and occasional ankle edema. She denies cyanosis, exertional dyspnea, or orthopnea. Physical examination revealed a slightly enlarged heart. A grade 5/6 pansystolic murmur was heard maximally at the lower left sternal border transmitted to the axilla and neck. Blood pressure was 128/78 mm Hg and pulse rate was 100 beats per minute with occasional premature beats. Electrocardiogram showed incomplete left frontal branch block and left ventricular hypertrophy. <h3>Discussion</h3> Dr. Laurence L. Robbins: Dr. Tomchik, what do you think about this case? Dr. Frederick S. Tomchik: The roentgenographic configuration of the heart is quite unusual (Fig 1). The apex is
JAMA Cardiology
Authors: Phil Fontanarosa, Annette Flanagin, Brenda Gregoline, Tracy Frey, Iris Lo, Kevin Brown, Amanda Ehrhardt, M Newman, Suzanne Walker, Connie Manno Senior, Sara Billings, Timothy Gray, Juliet Orellana, Paul Ruich, Kirby Snell, Catherine Alden, Stephanie Beckmeyer, Jane Calayag, Jan Clavey, Mary Coerver-Connolly, Paula Glitman, Bernadette Hromin, Paul Jaworski, Laura King, Regina Lilly, Molly O'donnell, Charon Pierson, Thressa Smith, Divya Sreekumar, Donna Thordsen, Christine Tilles, Caroline Woods, Editorial Assistant, Wanda Hill, Larry Bryant, Jacob Kendall-Taylor, Monica Managers, Fanny Staff, Anna Brown, Lee Bukowski, Lenette Calibeo, Tosca Gardner-Gullens, Erin Hall, Rachell Kato, Caroline Lozano, Angelia Sietmann, Michael Berkwits, Eric Butkus, Jesse Mcquarters, Elena Guobyte, Emily Ling, Daniel Morrow, Social Media, Eman Hassaballa, Reuben Rios, Mary Ferkaluk, Karen Bucher, Andy Rekito, Nick Reback, Lohitha Kethu, David Song, Deputy Livingston, Thomas Cole, Administration Director, Marla Hall, Deanna Willis, Yolanda Davis, Joseph Thornton, Deanna Bellandi, Jim Periodical, Thomas Easley, Brian Shields, Karen Adams-Taylor, Paul Gee, Monica Smith, Euwanaha Joiner-Smith, Joshua Lane, Cindy Rendlen, Ellen Yoshihara, Annissa Zak, Circulation Services, Julie Burton, Ronna Hewitt, Mary Sieck, Geneine Someren, Jamaal Vargas, Mike Bujewski, Nathan Mitre, Digital Production, Regina Brownlee, Amanda Camino, Brenda Chandler-Grayer, Emily Dunn, Amy Evers, Maleeka Holden, Teri Hutchison, Dan Knowles, Joshua Lampinen, Natalie Marsh, Patricia Panek, Marla Seidell, La Son, Diggs Sledge, Julian Graphics, Joe Amft, James Collver, Maria Duda, Fred Furtner, Carolyn Hall, Maria Kowalkowski, Proofreading Carol, Joy Farrell, Maria Giannini, Sasha Grossman, Judith Literskis, Teresa Omiotek, Michael Ryder, James Madara, Howard Bauchner, Robert Bonow, Patrick O'gara, Marc Sabatine, Clyde Boston, Michael Pencina, Carolina North, Adrian Hernandez, Mhs Durham, North Carolina, Mark Huff Man, Ajay Kirtane, New York, Roxana Mehran, Ann Navar, Carolina Christopher, J O'donnell, Massachusetts Boston, J Sanjiv, Mintu Shah, Gregg Fonarow, Los Angeles, Elizabeth Mcnally, Laine Thomas, Akhil Narang, Julia Getts, Eugene Braunwald, Robert Califf, Judith Hochman, Donald Lloyd-Jones, Scm Chicago, Michael Parmacek, Daniel Simon, Sidney Smith, Chapel Hill, Carolina Douglas, E Vaughan, Myron Weisfeldt, Maryland Douglas, P Zipes, Paul Armstrong, Shinya Goto, Peter Liu, Renato Lopes, Carolina Maseri, Dorairaj Prabhakaran, Hugh Watkins, Harvey White, Habib Yacoub
Journal: JAMA Cardiology (2020)
Sympathetic activity–associated periodic repolarization dynamics predict mortality following myocardial infarction
Authors: Konstantinos D. Rizas, Tuomo Nieminen, Petra Barthel, Christine S. Zürn, Mika Kähönen, Jari Viik, Terho Lehtimäki, Kjell Nikus, Christian Eick, Tim O. Greiner, Hans P. Wendel, Peter Seizer, Jürgen Schreieck, Meinrad Gawaz, Georg Schmidt, Axel Bauer
Journal: Journal of Clinical Investigation (2014)
Manual of Obstetrics.
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE SOLUBLE SPECIFIC SUBSTANCE OF PNEUMOCOCCUS
Authors: Michael Heidelberger, Walther F. Goebel, Oswald T. Avery
Journal: The Journal of Experimental Medicine (1925)

1. Refinements in the methods for the isolation of the soluble specific substances of Types II and III pneumococcus are described. These improvements have resulted in the isolation of the end-products in a form free from nitrogen and of enhanced activity with immune serum. 2. The soluble specific substance of Type I pneumococcus is described and shown to differ sharply from the corresponding substances of the other two types, each of which, in turn, differs from the other. 3. Progress is reported on the identification of the sugar units from which the polysaccharides are built up. 4. The evidence so far accumulated is believed to favor strongly the view that the polysaccharides isolated are the actual specific substances of Pneumococcus.
Abstract 335: Deletion Of Bmper In Mice Identifies A Novel Bmp-dependent Pathway For Regulating Cardiomyocyte Hypertrophy
Authors: Rongqin Ren, Monte Willis, Holly McDonough, Rusty Kelley, Yaxu Wu, Cam Patterson
Journal: Circulation (2007)

Bone morphogenetic proteins (BMP) are members of the TGF-β superfamily that regulate numerous cellular functions during development and in adulthood. We recently reported that Bmper (BMP-binding endothelial precursor-derived regulator) is an extracellular protein that modulates BMP activities. We created knock-in mice in which GFP replaces exons 1 and 2 of the Bmper gene, and found that ventricular cardiomyocytes abundantly expressed Bmper in vivo, especially during late stages of cardiac development in utero. To explore the role of Bmper in cardiomyocyte differentiation, in vitro hypertrophy assays were performed using embryonic day 18.5 cardiomyocytes from Bmper −/− and Bmper +/+ mice and cells were treated with vehicle, BMP2 (100 ng/ml), or the alpha-adrenergic agonist phenylephrine (100 μM) for 48 hours. Phenylephrine treatment induced a ~30% cell size increase in wild-type cardiomyocytes, whereas to our surprise BMP2 elicited an ~80% increase in size, indicating a potent hypertrophic effect of BMP2 on cardiomyocytes. In comparison to wild-type cardiomyocytes, Bmper −/− cells were ~100% larger without any treatment and were not further responsive to BMP2 or phenylephrine. Real-time PCR analysis of BMP2- and phenylephrine-treated wild-type cardiomyocytes revealed up-regulation of cardiac differentiation markers (including atrial natriuretic factor, smooth muscle actin, alpha-myosin heavy chain, and GATA2) and BMP signaling components (including BMP ligands, receptors, and Smad1/5/8). These same markers were upregulated in Bmper −/− cardiomyocytes, even in the absence of treatment. These observations indicate that the BMP pathway has a previously undisclosed role in regulating hypertrophy in cardiomyocytes and that Bmper, as a BMP antagonist, dramatically attenuates BMP-induced cardiomyocyte hypertrophy.
HANS QUECKENSTEDT (1876-1918) NEUROPHYSIOLOGIST
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Training in the United States
Authors: Asrar Rashid, Mark Twite, Sunil Bhudia
Journal: BMJ (2003)

The “American dream” has seen a steady flow of scientists and doctors to the United States. <b>Asrar Rashid</b>, <b>Mark Twite</b>, and <b>Sunil Bhudia</b> have tips for doctors thinking of making “the dream” come true