tbuckley/cabot-search huggingface dataset:
Gastrin
Authors: William F. Lipp
Journal: JAMA (1967)

This excellent volume records the proceedings of a conference organized by Morton I. Grossman in order to celebrate Prof R. A. Gregory's recent isolation of chemically pure gastrin from porcine stomachs, the determination of its structure and its synthesis, as well as his rather convincing evidence that the biologically active substance in the pancreatic adenoma of the Zollinger-Ellison syndrome is probably gastrin. The exciting story of gastrin is told in detail from Edkins (1905), the discoverer of gastrin (who paradoxically and ironically was measuring for the most part histamine activity), to Gregory's characterization of two gastrins reported in 1964. Perhaps more important than the outstanding formal presentations was the free and spirited exchange of ideas following each paper, discussions skillfully led by the chairman. While some questions have been answered, there is still much to be learned, and the direction of future investigation is clearly indicated. The sites of gastrin
The cost of hospitalizations for firearm injuries
Authors: Ralph A. Korpman, Thomas L. Lincoln
Journal: JAMA (1989)

<h3>In Reply. —</h3> In their letter, the writers make multiple assertions ad hominem, but only limited space is available for a short rebuttal. We editorialized that the computer-stored medical record should serve the patient first and that technical design should be subservient to that goal. The task is difficult. Elsewhere<sup>1</sup>we note that "problems... arise when one attempts to integrate the rich knowledge-base and behavioral variety of health care with the logical constraints of computer-oriented information processing." Everyone has experienced computerized procedures that are dictatorial or infuriatingly awkward—mocking Wiener's ideal (and warning) that computers should promote "the human use of human beings." A timely article<sup>3</sup>subtitled "New Technologies, Obsolete Organizations" recently reviewed the relative merits of a consistent overall design vs incremental improvement via networked islands of automation, citing Federal Express as a system that needs all of its parts to offer a significant new service. These authors
Steroid-antibiotic combinations.
Journal: BMJ (1977)

then we need to know that the advice given is sound and that it is effective in changing attitudes, in reducing delay in diagnosis, and-ultimately-in reducing mortality, and especially mortality in youth and middle age.The Cancer Research Campaign has recently allocated some of its funds to support research projects concerned with cancer education, so that finance is available for evaluation.Short of money, the NHS needs to make the best use of existing knowledge; and prevention offers the best hope of reducing both the toll of cancer and the demands it makes on resources.
Some Aspects of the Problem of Individual Predisposition to Silicosis
Authors: Boris A. Katsnelson, Eugene V. Polzik, Larissa I. Privalova
Journal: Environmental Health Perspectives (1986)

Based on experimental and epidemiological data findings presented here, as well as on data of other investigators, the authors conclude that a wide interindividual variability of susceptibility to silicosis is a real phenomenon. This susceptibility depends on both intrinsic features of the host and the influence of many environmental factors. The effect of any such factor is realized at different stages of silicosis pathogenesis and in close interrelation with the influence of other factors. The necessity of multifactorial analysis is stressed, and an example of such analysis is presented.
Starting angiotensin converting enzyme inhibitors in primary care is safe
Journal: BMJ (1998)

Nut consumption may protect against heart diseaseAlthough nuts are high in fat, the fatty acids are mostly monosaturated or polyunsaturated, which have beneficial effects on blood lipids.In a large prospective study of women, Hu et al (p 1341) found an inverse association between nut consumption and incidence of coronary heart disease.Women who frequently consumed nuts (>5 times per week) had a significantly lower risk of non-fatal myocardial infarction and fatal coronary disease after accounting for age, smoking, and other known coronary risk factors than women who rarely (never or less than once a month) ate nuts.
AMA grams
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Oral Presentations
Authors: Subhas Banerjee, Barham Abu Dayyeh, Cme Credits, Daniel Sze, Barham Dayyeh, Thomas Boyer, K Reddy, John Lake, John O'grady, James Trotter, Kymberly Watt, Geoffrey Mccaughan, Richard Sterling, Ayman Koteish, Oren Fix, Arun Sanyal, Gyongyi Szabo, Judith Podskalny, Bruce Luxon, Adrian Di Bisceglie, W Kim, Anna Diehl, K Reddy, Paul Martin, Zachary Goodman, Nezam Afdhal, Andrew Muir, Elizabeth Brunt, Robert Fontana, Jeffrey Brown, Lewis Roberts, Jayant Talwalkar, Marion Peters, Heiner Wedemeyer, Cynthia Levy, Deirdre Kelly, Gary Davis, Bruce Bacon, William Lee, Marc Ghany, Michael Fried, Tram Tran, Nancy Reau, Ira Jacobson, Hugo Vargas, Timothy Davern, Florence Wong, Mary Rinella, Kenneth Cusi, Timothy Morgan, Guadalupe Garcia-Tsao, Kevin Mullen, Samuel Lee, J Hay, Arthur Mccullough, Michael Lucey, Lawrence Friedman, Stephen Caldwell, Robert Hawes, Jasmohan Bajaj, Michael Charlton, Laura Kulik, Kimberly Brown, Jeffrey Crippin, Tse-Ling Fong, Adrian Reuben, John Ham, David Mulligan, Sasan Roayaie, Kenneth Chavin, Jayanta Roy-Chowdhury, Vicente Arroyo, Hcv Replication, Andrew Talal, Raymond Chung, Emw-3 Triggers, Fibrosis In Nash, Ariel Feldstein, Detlef Schuppan, Cholangiocyte Pathobiology, Gianfranco Alpini, Marco Marzioni, Emw-5 Microbiome, Bernd Schnabl, David Brenner, Rohit Kohli
Journal: Hepatology (2013)

The overall goal of this activity is to educate the target audience in state-of-the-art best practices pertaining to diagnostic and therapeutic endoscopy in patients with hepatobiliary disease.This should result in a significant improvement in their understanding of the relative benefits and risks of these modalities, in optimizing patient selection for different endoscopic interventions and in the performance of these endoscopic interventions.
Mortality rates, causes of death, and health status among displaced and resident populations of Kabul, Afghanistan
Authors: B. D. Gessner
Journal: JAMA (1994)

<h3>Objective.</h3> —To determine the mortality and health effects from the current civil war in Kabul, Afghanistan. <h3>Subjects.</h3> —One resident population and one displaced population. <h3>Design.</h3> —Between November 22 and December 16,1993, we conducted a retrospective, population-based, household survey, interviewing 312 displaced families and 300 resident families. <h3>Results.</h3> —During the 285 days before the survey, the highest average daily crude mortality rate and the mortality rate for those younger than 5 years (0.9 and 2.6 per 10 000 population per day, respectively) were among residents who had lived at their current location for 10 months or less. The average daily crude mortality rate and the mortality rate for those younger than 5 years were lower among displaced persons (0.6 and 1.9 per 10 000 per day) and lowest among residents who had lived at their current location for more than 10 months (0.5 and 0.6 per 10000 per day). Overall, the most common cause of death for both groups was gunshot or other war trauma; for children younger than 5 years, deaths resulting from measles, diarrhea, and acute respiratory tract infection predominated. <h3>Conclusions.</h3> —While provision of basic public health measures would likely decrease mortality among both displaced and resident populations, the most urgent health need is for a cessation of hostilities against the civilian population. During humanitarian relief operations, organizations should not focus exclusively on persons identified as displaced. (<i>JAMA</i>. 1994;272:382-385)
Prospective study of cognitive function (cog fcn) in women with early-stage breast cancer (BC): Relationship between perceived and measurable cognitive deficits.
Authors: Lara Heflin, Sally Fang, Amy N. DeLuca, Michelle E. Melisko, Mark M. Moasser, John W. Park, Amy Jo Chien, Pamela N. Munster, Susan M. Landau, William J. Jagust, Joel H. Kramer, Hope S. Rugo
Journal: Journal of Clinical Oncology (2013)

105 Background: Cognitive complaints are common among patients (pts) receiving adjuvant therapy (Rx) for early stage BC. Longitudinal prospective data is needed to help understand the relationship between measured cog fcn, patient reported cognitive changes, and patient reported depression and fatigue. We conducted a prospective trial to evaluate the effects of chemo- (CTX) and hormone therapy (HRx) on brain and cog fcn in pts with early stage BC using multiple objective and subjective tests as well as MRI/PET imaging. Here we report relationships between objective measures and patient reported outcomes (PRO). Methods: Eligibility included female pts planning to receive adjuvant Rx for ESBC. Pts were enrolled in 3 Rx groups (grps): CTX, CTX and HRx, and HRx, with a 4 th no Rx age/education matched control group. All pts underwent a battery of objective and subjective cog tests before start of rx, 1 mo after CTX or 5 mo after start of HRx (FU1), then 9 mo (FU2) and 18 mo (FU3) after CTX. Brain MRI, PET and serum estradiol were performed at baseline, FU1 and FU2. Results: 81 pts were enrolled as follows: 14 CTX, 33 CTX and HRx, 22 HRx, and 12 control. 90% completed FU1, 72% FU2, and 62% FU3, with 29 pts waiting to complete testing. Demographics were similar between grps, median age was 54 (range 34-71), 78% were Caucasian. At FUP1, depression (BDI-II) and fatigue predicted poorer overall perceived cog fcn (FACT-Cog); decline in letter fluency (FAS) on cog testing also predicted poorer overall perceived cog fcn (FACT-Cog). Decline in verbal memory (CVLT-II) predicted perceived memory deficits (FACT-Cog Memory), even after controlling for depression and fatigue. Conclusions: In pts receiving adjuvant Rx for early stage BC, depression, fatigue, and decline in letter fluency predicted poorer perceived cog fcn. Decline in verbal memory independently predicted perceived memory deficits, demonstrating that PRO are related to actual deficits in cog fcn. Future intervention studies should focus on these factors. Funding: NIH R01 1AG025303-01A2. Clinical trial information: 00755313.
Platelet-Inhibiting Drugs in the Prevention of Clinical Thrombotic Disease
Authors: Edward Genton, Michael Gent, Jack Hirsh, Laurence A. Harker
Journal: New England Journal of Medicine (1975)

Venous ThromboembolismThe role of platelets in the development of venous thrombi is uncertain. The traditional view is that venous thrombi occur as a result of fibrin deposition with the resulting formation of a red thrombus composed of erythrocytes enmeshed in a fibrin network.1 This thesis is supported by platelet and fibrinogen kinetic studies and the effectiveness of anticoagulants in the prophylaxis and treatment of venous thromboembolism. However, some histologic studies77 78 79 report the presence of platelet aggregates at the apparent site of origin of venous thrombi, suggesting that platelets may take part in the initiation of . . .
JOSEPH JULES DEJERINE (1849-1917)
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The effectiveness of tositumomab and iodine I 131 tositumomab in relapsed/refractory follicular grade 1/2 and small lymphocytic non-Hodgkin's lymphoma (NHL)
Authors: J. O. Armitage, J. P. Leonard, S. A. Gregory, S. J. Horning, A. D. Zelenetz, M. S. Kaminski, R. I. Fisher
Journal: Journal of Clinical Oncology (2004)

6573
Legionnaires' Disease
Authors: Edward H. Kass
Journal: New England Journal of Medicine (1977)

The terror of the unknown is seldom better displayed than by the response of a population to the appearance of an epidemic, particularly when the epidemic strikes without apparent cause. Philadelphia, in July and August, 1976, experienced such a shattering event, and such is the power of the media that the disease, dubbed Legionnaires' disease, immediately became a household term. Articles about the disease have been a regular feature of the public press. New cases have been identified in different parts of the country and abroad, and rumors that were at first manifestations of public hysteria and concern have been . . .
Chiropractors Not Licensed in West Virginia.
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 3098: Maximizing the sensitivity and utility of tissue biopsy by analyzing RNA and incorporating multiple immunotherapy markers
Authors: Christopher Kasbek, Cai Chen, Nouran Almalki, Jillian Cortese, Jun Huang
Journal: Cancer Research (2019)

Abstract Next-generation sequencing panels are becoming more widely accepted as diagnostics for guiding personalized medicine in oncology. Some weaknesses of current NGS panels include: a lack of prediction of the patient’s response to the recently approved PD-1 checkpoint inhibitors, low sensitivities of fusion variant detection due to the complexity of the translocation events that can occur at the DNA level, and the need for matched normal sample. We are developing a 371-gene panel that uses both DNA and RNA from a single non-matched FFPE sample to guide targeted and immunotherapy decisions. Fusions are identified in RNA, while copy number variation, tumor mutation burden (TMB), microsatellite instability (MSI), HLA typing, single-nucleotide variants, and small insertion/deletion variants are identified in DNA. All exons plus UTR regions of 371 genes are covered at a mean depth of &amp;gt;500X. To validate the TMB test, whole-exome sequencing data from 376 colon adenocarcinoma samples was analyzed with our pipeline using a 4-fold cross-validation design. TMB-high vs. TMB-low was called with 95% accuracy, compared to 90% accuracy of a competitor’s panel. For MSI, the canonical five mononucleotide-repeat sites are interrogated with a limit of detection of 2-5%. RNA samples with Dv200 &amp;gt;10% can be used to identify fusion variants. RNA is converted to cDNA and hybridized with a mixture of probes containing ≈300 well-known fusion junctions and full exon sequences of 37 of the 371 genes which are relevant to fusions. This design leads to improved fusion detection compared to the standard DNA detection, while allowing for the identification of novel fusion junctions. Gender and common SNP’s in DNA and RNA are used to prevent sample misidentification. The accuracy and comprehensiveness of this panel should maximize benefit to the patient. Note: This abstract was not presented at the meeting. Citation Format: Christopher Kasbek, Cai Chen, Nouran Almalki, Jillian Cortese, Jun Huang. Maximizing the sensitivity and utility of tissue biopsy by analyzing RNA and incorporating multiple immunotherapy markers [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3098.
Cloning of the Promoter Region of Human Endoglin, the Target Gene for Hereditary Hemorrhagic Telangiectasia Type 1
Authors: Carlos Rı́us, Joshua D. Smith, Nuria Almendro, Carmen Langa, Luisa M. Botella, Douglas A. Marchuk, Calvin P.H. Vary, Carmelo Bernabéu
Journal: Blood (1998)
Topics in radiology/case of the month. Acute dyspnea in a young woman taking birth control pills
Authors: T. E. Goffman
Journal: JAMA (1984)

<h3>History</h3> A 26-year-old black woman was initially seen with an acute onset of shortness of breath, right-sided pleuritic pain in the chest, and a history of one week of pain without swelling of the right leg. She denied any unusual medical history. A routine employment roentgenogram of the chest obtained two years earlier was normal. Her only medication was a mestranol-norethindrone combination product. Physical examination revealed a well-developed, well-nourished woman in moderate respiratory distress. Her BP was 110/70 mm Hg; heart rate, 108 beats per minute; respirations, 28/min; and temperature, 37.8 °C. Pertinent physical findings included a left conjunctival nodule, right supraclavicular adenopathy, and bronchial breath sounds heard over the right upper-lung region. Her extremities were normal. Findings from routine laboratory studies were unremarkable except for an ESR of 56 mm/hr. Arterial blood gas levels on room air were Po<sub>2</sub>, 77 mm Hg; Pco<sub>2</sub>, 30 mm Hg; and
Die Unfruchtbarkeit der Frau: Bedeutung der Eileiterdurchblasung für die Erkennung der Ursachen, die Voraussage und die Behandlung.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prostitution: An Investigation of Its Causes, Especially with Regard to Hereditary Factors. By<i>Tage Kemp.</i>English Translation by<i>Elsie-Marie Werner Kornerup, B. A.</i>(Copenhagen: Levin &amp; Munksgaard, Ejnar Munksgaard, 1936.)
Authors: W. L. T.
Journal: American Journal of Psychiatry (1937)
Abstracts
Journal: Annals of the Rheumatic Diseases (1963)

Working at the Irvington House After-Care Clinic, New York University School of Medicine, the authors have studied the effect of physical activity on the progress of rheumatic heart disease in 216 patients who were followed up for an average of 21 years after an attack of rheumatic fever.In 26 (12 per cent.) of these patients the "objective cardiac status", evaluated by means of standard criteria for the findings on auscultation and fluoroscopy, deteriorated.In fifty (23 per cent.)there was improvement.In 140 (65 per cent.)there appeared to have been no change.These percentages remained essentially unchanged when the findings were analysed according to the enforce- ment or absence of restrictions upon the patients' physical activities, during their school life, at home, or in later life after leaving school.The results suggest strongly that no really useful medical purpose is served by many of the physical and other restrictions which are *often imposed upon patients who are known to have
HERNIA REDUCED "EN BLOC"
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal