tbuckley/cabot-search huggingface dataset:
Review of urine microscopy for bacteriuria
Authors: R. D. Jenkins
Journal: JAMA (1986)

Urine microscopy for bacteriuria remains a useful and valid technique for the evaluation of urinary tract infection; however, established interpretive criteria are not agreed on. Our own data and a review of the literature demonstrate that reliable data can be obtained by enumerating the organisms observed in stained or unstained centrifuged and stained uncentrifuged urine specimens. Criteria are given for the interpretation of urine microscopy for maximum sensitivity and specificity for each method reviewed. For clinicians desiring to perform urine microscopy, we recommend the use of oil-immersion microscopy of Gram-stained centrifuged urine sediment and suggest that observing at least one organism per oil-immersion field corresponds with 95% sensitivity and that observing more than five organisms corresponds with 95% specificity for bacteriuria at a level of 105 or more colony-forming units per milliliter. Further testing will be required on any negative specimen from a symptomatic patient. (<i>JAMA</i>1986;255:3397-3403)
Eleventh Annual Symposium for Referring Physicians
Journal: JNCI Journal of the National Cancer Institute (1976)

Eleventh Annual Symposium for Referring Physicians Get access JNCI: Journal of the National Cancer Institute, Volume 57, Issue 4, October 1976, Page 969, https://doi.org/10.1093/jnci/57.4.969-b Published: 01 October 1976
Managing acute renal colic across the primary-secondary care interface: a pathway of care based on evidence and consensus
Journal: BMJ (2003)

Cross-country comparisonsThere is evidence in developed and in developing countries that acknowledging the sexual activity of adolescents and meeting their sexual health needs with targeted education and preventive care services can help reduce risky sexual behaviour and its consequences. 18 19 The sexual health needs of young people in Nigeria are high, as evidenced by the prevalence of pregnancy and sexually transmitted disease, including HIV/AIDS.By age 13 years over a quarter of the students in our study were sexually active.Among US students surveyed in the same year (1999), sexual activity by age 13 years was reported by 5.5% of white students, 20.5% of black students, and 9.2% of Hispanic students.Whereas 39% of female students in our study had had a past or current pregnancy, the rate among female high school students in the United States in the same year was 7.6%. 16 ConclusionsThe findings of our study can help programme planners in Nigeria tailor prevention strategies to the needs of adolescent school students but should not be generalised to adolescents who are out of school.Work that advances our understanding of the contexts of time, place, and people around adolescents in Nigeria is needed if we are to interpret international research correctly and plan interventions that are appropriate and effective.
Identification of Pasteurella tularensis by immunofluorescence
Authors: J. D. White
Journal: JAMA (1965)

TULAREMIA is a sporadic disease in man. Its diagnosis may be difficult, particularly when the disease manifests itself in an atypical form or has been modified by antibiotic therapy. The most satisfactory method for positive diagnosis is bacteriologic culture.<i>Pasteurella tularensis</i>is cytotropic with fastidious growth requirements and, thus, special media and some degree of microbiological skill are needed to ensure recovery of the organisms in culture. In addition, there is a definite danger of infection for the personnel in the laboratory. Therefore, an accurate and rapid method for the identification of<i>P tularensis</i>that is not dependent upon the culture of viable organisms would be of considerable value. The technique for identifying antigens by fluorescent-tagged antibodies was introduced by Coons and Kaplan,<sup>1</sup>and after some technical modifications has been used in many areas of research and clinical application. The reviews of Coons,<sup>2</sup>Cherry and co-workers,<sup>3</sup>Beutner,
Peroxisome proliferator-activated receptor-γ haploinsufficiency enhances B cell proliferative responses and exacerbates experimentally induced arthritis
Authors: Keigo Setoguchi, Yoshikata Misaki, Yasuo Terauchi, Toshimasa Yamauchi, Kimito Kawahata, Takashi Kadowaki, Kazuhiko Yamamoto
Journal: Journal of Clinical Investigation (2001)

Peroxisome proliferator–activated receptor-γ (PPARγ) controls adipogenesis and glucose metabolism. It was reported recently that PPARγ activation by its agonistic ligands modifies lymphocyte function. Since synthetic ligands are known to exert their effect via PPARγ-dependent and -independent pathways, we examined the physiological role of PPARγ in lymphocytes by using heterozygote mutant mice in which one allele of PPARγ is deleted (PPARγ+/–). In contrast to T cells, which did not exhibit a significant difference, B cells from PPARγ+/– showed an enhanced proliferative response to stimulation by either lipopolysaccharide or cross-linking of antigen receptors. Dysregulation of the NF-κB pathway in B cells from PPARγ+/– was indicated by spontaneous NF-κB activation, as well as increased IκBα phosphorylation and gel-shift activity following LPS stimulation. Mice primed with either ovalbumin or methylated BSA also showed enhanced antigen-specific immune response of both T and B cells, an immunological abnormality that exacerbated antigen-induced arthritis. These findings indicate that PPARγ plays a critical role in the control of B cell response and imply a role in diseases in which B cell hyperreactivity is involved, such as arthritis and autoimmunity.
DEATH OF JOHN B. HAMILTON, M.D., LL.D.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TRICHINOSIS, WITH ESPECIAL REFERENCE TO THE INCREASE AND ORIGIN OF THE EOSINOPHILIC CELLS.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ABSTRACTS
Authors: Mario Baldini, Klaus Betke, Arthur Bloom, Thomas Bothwell, S Africa, John Bridges, Jacques Caen, Jyoti Chatterjea, Pietro Denicola, M Smith, M White- Side, D Campbell, E Izdebska, S Maj, I Daszy, Vera Polycythemia, I Zatoiiski, T Ktviatkowska, N Baranowski, J Viala, M Dechavanne, Y Barbier, P Michaud, L Revol, E Munity
Journal: Blood (1971)
Diagnostik der Kinderkrankheiten mit besonderer Berücksichtigung des Säuglings.
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Biomarkers for immune checkpoint blockers
Authors: Kirsty Wienand, Margaret A. Shipp
Journal: HemaSphere (2018)

Dana-Farber Cancer Institute, Boston, MA, USA This is an open access Abstract Book distributed under the Attribution-NonCommercial-NoDerivs (CCBY-NC-ND), which allows third parties to download the abstracts and share them with others as long as they credit the author and the abstract book, but they cannot change the content in any way or use them commercially. http://creativecommons.org/licenses/by-nc-nd/4.0
A clinical study of lectin-reactive alpha-fetoprotein as an early indicator of hepatocellular carcinoma in the follow-up of cirrhotic patients
Authors: K SHIRAKI
Journal: Hepatology (1995)

Levels of two types of lectin-reactive alpha-fetoprotein (AFP), designated AFP-L3 and AFP-P4+P5, were analyzed with Lens culinaris agglutinin A and AFP-P4+P5 with erythroagglutinating phytohemagglutinin, respectively, in an attempt to determine the utility and significance of these macromolecules as early indicators of hepatocellular carcinoma during the periodic follow-up of cirrhotic patients. The subjects were 51 of 190 consecutive cirrhotic patients in whom hepatocellular carcinoma developed during a 6-year follow-up period and 21 cirrhotic patients without hepatocellular carcinoma. Serum AFP levels were of limited value to diagnose and predict hepatocellular carcinoma. The relative levels of AFP-L3 and AFP-P4+P5 in patients with hepatocellular carcinoma at the time of tumor detection were significantly higher than those in patients with cirrhosis. The sensitivity was 61%, and the specificity was 90%. Fourteen patients (48%) of 29 patients with small hepatocellular carcinomas less than 2 cm in diameter showed elevated percentage of lectin-reactive AFP. Retrospective examination of 21 patients who were positive for lectin-reactive AFP at diagnosis of hepatocellular carcinoma showed that 41% of them had already expressed lectin-reactive AFP 12 months before the direct detection of hepatocellular carcinoma by diagnostic imaging. These results lead us to conclude that the level of lectin-reactive AFP is a suitable predictive marker for the early recognition of hepatocellular carcinoma in the follow-up of patients with cirrhosis, and that measurements of the level of lectin-reactive AFP should be added to the screening methods that are now in use. (Hepatology 1995; 22:802–807.)
A Pocket Medical Dictionary, Giving the Pronunciation and Definition of about 12,000 of the Principal Words used in Medicine and the Collateral Sciences.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Treatment of gonorrhea in males with cephaloridine
Authors: J. B. Lucas
Journal: JAMA (1966)

Since the isolation of a strain of<i>Cephalosporium acremonium</i>by Brotzu in 1945,<sup>1</sup>the recovery of seven natural antibiotic substances from this fungus has been reported.<sup>2</sup>One of these antibiotic substances is cephalosporanic acid.<sup>3</sup>This nucleus is chemically closely related to the penicillin nucleus, 6-aminopenicillanic acid, differing by having a fused dihydrothiazine B lactam ring, rather than a fused thiazolidine B lactam ring.<sup>4</sup>Synthetic manipulation of the 7-aminocephalosporin nucleus by Chauvette et al<sup>5</sup>has resulted in the development of cephalothin (Keflin), now available commercially in the United States. A second important derivative, cephaloridine, chemically 7-[α-(2-Thienyl) acetamido]-3-(1-pyridylmethyl)-3-cephem-4-carboxylic acid betaine, has been produced in England and has been the subject of several favorable clinical reports from that country.<sup>6,7</sup> Cephaloridine has essentially the same spectrum of antimicrobial activity as cephalothin, but is more potent against gram-positive organisms. Generally, the pharmacological properties of the two drugs are similar.
Abstract 750: Short-Term Postoperative Amiodarone Use Decreases the Incidence of Atrial Fibrillation in Patients Undergoing Cardiac Surgery
Authors: James R Cook, Christos Mandanis, John A Rousou, Mathias L Stoenescu, David W Deaton, Joseph E Flack, Daniel T Engelman
Journal: Circulation (2008)

Introduction: Atrial fibrillation (AF) is common after cardiac surgery and related to postoperative complications and length of stay (LOS). We studied the effect of postoperative use of amiodarone (amio) on the incidence of AF, neurologic and pulmonary events, as well as LOS in 694 patients (pts) with no history of AF, who underwent cardiac surgery at one institution. Methods: During calendar year 2007, 694 consecutive pts were evaluated. From July through December, 311 pts (amio group) received 150 mg intravenous amiodarone bolus at the end of surgery, followed by 400 mg orally twice a day for 7 days, and 200 mg orally daily for 7 more days. If AF developed before oral amiodarone could be started, pts received additional 150 mg drug boluses. Outcomes were compared against a control group of 307 pts who underwent cardiac surgery at the same institution during the first 6 months of 2007. AF was defined as any episode of atrial fibrillation requiring treatment. Results: The mean patient age was 67±12 yrs, 33% were female and 90% received postoperative beta-blocker. AF occurred in 29% of the cohort, and was significantly reduced from 34% in the control group to 24% in the amio group (p&lt;0.004). The reduction in AF was consistent for patients undergoing CABG and/or valve surgery. There was no increase in ventilator time (median 13 hrs) or pulmonary complications in the amio group. Neurologic events were low (4%) and equal in both groups as was the need for postoperative pacemaker therapy (4%). The median LOS was 10 days and not affected by amio treatment. Conclusions: Short-term use of amiodarone postoperatively decreases the incidence of AF in patients treated with beta-blocker after cardiac surgery. No increase in adverse events was identified nor influence on LOS. Thus, amiodarone treatment postoperatively appears safe and effective.
Antibiotic Allergies
Authors: Alan Hugh Bennett
Journal: JAMA (1965)

<h3>To the Editor:—</h3> Problems arising from management of children with antibiotic allergies and frank allergic rashes are exemplified by the following story. Last week I saw a 2 1/2-year-old boy who had been treated with erythromycin, for two days, by another physician, for a pustular pharyngitis. A throat culture had been taken from which β-hemolytic streptococci were grown and were probably the offending organism. The mother had given this physician a history of the child's sensitivity to penicilln, and the regimen of erythromycin was continued. The boy developed a generalized rash on the third day, raising the problem of determining the antibiotic of choice for further treatment. A more detailed history revealed an astonishing use of antibiotics in the 2 1/2 years of this healthylooking boy's life. The story of sensitivity to penicillin had begun six months earlier, when because of "cold and fever" he had received a "shot of
Physics and Medicine of the Upper Atmosphere: A Study of the Aeropause.
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Impending Laminectomy
Authors: William Hoagland
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Therapeutic Approaches To Hemoglobin Switching In Treatment Of Hemoglobinopathies
Authors: J. Stamatoyannopoulos
Journal: Annual Review of Medicine (1992)

The past decade has witnessed profound increases in knowledge of the structure, function, and developmental regulation of the human globin genes. This information has deepened our understanding of the molecular and cellular mechanisms underlying inherited disorders affecting hemoglobin, and it has provided a new perspective for attaining meaningful increases in fetal hemoglobin synthesis in the management of sickle cell anemia and beta thalassemia. Efforts to provide therapy for these disorders are based on three factors: an understanding of their pathophysiology; the potential for fetal hemoglobitno alter its manifestation; and the concept that developmental changes in globin gene expression might be reversed by manipulating cellular and molecular regulatory mechanisms. In this review we discuss these topics and examine critically recent efforts to apply various pharmacological agents to in vitro, animal, and human models with the goal of increasing HbF synthesis. Several agents have demonstrated activity in patients with hemoglobin disorders. One such agent, hydroxyurea, has been shown to be potentially efficacious in phase II clinical trials in patients with sickle cell anemia and awaits testing in a placebo-controlled phase III study.
ILLEGAL ADVERTISEMENTS IN IOWA.
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Errors in Abstract and Main Results
Journal: JAMA Network Open (2021)

Hana Kahleova, MD, PhD; Kitt Falk Petersen, MD; Gerald I. Shulman, MD, PhD; Jihad Alwarith, BS; Emilie Rembert, BS; Andrea Tura, PhD; Martin Hill, PhD; Richard Holubkov, PhD; Neal D. Barnard, MD
Reply
Authors: Maria Lucia Narducci, Annalisa Grasselli, Luigi M. Biasucci, Antonella Farsetti, Antonino Mulè, Giovanna Liuzzo, Giampaolo Niccoli, Rocco Mongiardo, Alfredo Pontecorvi, Filippo Crea
Journal: Journal of the American College of Cardiology (2008)