tbuckley/cabot-search huggingface dataset:
Unilateral Proptosis
Authors: Javier Munoz, Razelle Kurzrock
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Author Index
Authors: John B. Martin, R.O. Pihl, W.D. TenHouten, K.D. Hoppe, J.E. Bogen, D.O. Walter, Rishun Sinzato, Osamu Fukino, Hajime Tamai, Hitoshi Isizu, Tetsuya Nakagawa, Manfred Beutel, H.M. van der Ploeg, E.T. van Buuren, P. van Brummelen, Giovanni A. Fava, Thomas N. Wise, George Molnar, Maria Zielezny, Han Kutz, Jane Leserman, Claudia Dorrington, Catherine H. Morrison, Joan Z. Borysenko, Herbert Benson, Yujiro Ikemi
Journal: Psychotherapy and Psychosomatics (1985)
Welcome to the physicians of Southeast Asia
Authors: G. D. Lundberg
Journal: JAMA (1985)

In January 1985 we will begin monthly publication of the next edition of the<i>Journal of the American Medical Association</i>in Hong Kong. The Southeast Asian edition of<i>JAMA</i>(<i>SEA-JAMA</i>) will be distributed in nine countries: Burma, Hong Kong, Indonesia, Malaysia, the Philippines, Singapore, Sri Lanka, Taiwan, and Thailand. This edition is added to those already serving the People's Republic of China, Japan, France, Switzerland, West Germany, Belgium, and Italy.<sup>1</sup>We are pleased with all of these efforts, but we are particularly excited about<i>SEAJAMA</i>because it is new and different in so many ways. It will be our first major entry into what is known as the "third world." Of course, our regular English-language version circulates in scores of third world countries, but the number of subscriptions is small and includes mostly universities, hospitals, companies, and government and private institutions. SEAJAMA, in contrast, will serve primarily direct
Immunological cross‐reactivity of hemoglobins in the Diptera familiy <i>Chironomidae</i>
Authors: X. Baur, V. Liebers, G. Mazur, W.‐M. Becker, S. L. Kagen, K. Kawai
Journal: Allergy (1991)

Polyclonal human IgE antibodies of patients sensitized to one species of the Diptera family Chironomidae as well as polyclonal rabbit anti‐ Chi t I hyperimmune serum recognize antigenic sites present in nearly all of the 33 species of this insect family. Evolutionary distantly related genera usually show weaker antibody binding. According to the pattern of reactivity of rabbit anti‐ Chi t I ‐component III, expression of the epitopes of this molecule varies considerably in the genera Chiranomus and Clyptotendipes ; it appears to be almost totally absent in all other species. Of five monoclonal antibodies raised against Chi t I ‐component III, two recognize an epitope which is expressed in nearly all closely related species. Three monoclonal antibodies recognize epitopes which are expressed in only a few species of the same genus. Our results demonstrate the presence of common as well as species‐specific epitopes in chironomid hemoglobins which behave as potent inhalant allergens.
COMMON SKIN DISEASES
Authors: J. T. Ingram
Journal: BMJ (1955)

<h3>Objectives</h3> To characterise gaps in antihypertensive treatment in people with hypertension and statin treatment in people with cardiovascular diseases (CVD) in a large urban population and quantify the health and economic impacts of their optimisation. <h3>Design</h3> A cross-sectional population study and a long-term CVD decision model. <h3>Setting</h3> Primary care, UK. <h3>Participants</h3> All adults with diagnosed hypertension or CVD in a population of about 1 million people, served by 123 primary care practices in London, UK in 2019. <h3>Interventions</h3> Following UK clinical guidelines, all adults with diagnosed hypertension were categorised into optimal, suboptimal and untreated groups with respect to their antihypertensive treatment, and all adults with diagnosed CVD were categorised in the same manner with respect to their statin treatment. <h3>Outcomes</h3> Proportion of patients suboptimally treated or untreated. Projected cardiovascular events avoided, years and quality-adjusted life years (QALYs) gained and healthcare costs saved with optimised treatments. <h3>Results</h3> 21 954 of the 91 828 adults with hypertension (24%; mean age 59 years; 49% women) and 9062 of the 23 723 adults with CVD (38%; mean age 69 years; 43% women) were not optimally treated with antihypertensive or statin treatment, respectively. Per 1000 additional patients optimised over 5 years, hypertension treatment is projected to prevent 25 (95% CI 16 to 32) major vascular events (MVEs) and 7 (3 to 10) vascular deaths, statin treatment, 28 (22 to 33) MVEs and 6 (4 to 7) vascular deaths. Over their lifespan, a patient with uncontrolled hypertension aged 60–69 years is projected to gain 0.64 (95% CI 0.36 to 0.87) QALYs with optimised hypertension treatment, and a similarly aged patient with previous CVD not optimally treated with statin is projected to gain 0.3 (0.24 to 0.37) QALYs with optimised statin treatment. In both cases, the hospital cost savings minus extra medication costs were about £1100 per person over remaining lifespan. <h3>Conclusions</h3> Optimising cardiovascular treatments can cost-effectively reduce cardiovascular risk and improve life expectancy.
Medical Heuristics
Authors: Donald A. Gerber
Journal: Annals of Internal Medicine (1996)

Letters1 July 1996Medical HeuristicsDonald A. Gerber, MDDonald A. Gerber, MDState University of New York Health Science Center at Brooklyn, Brooklyn, NY 11203Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-1-199607010-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Dr. McDonald [1] mentions that Sutton's Law is “named after the famous bank robber who explained that he robbed banks because ‘that's where the money is.’” He then interprets the Law by saying it “reminds us to try a common diagnosis to explain symptoms before resorting to an uncommon one, because the statistics favor such bets.” This interpretation of Sutton's Law is overly broad. The principle was first enunciated by William Dock to support his recommendation to the house-staff that a patient he thought might have schistosomiasis should have a liver biopsy [2]. Thus, in the strictest ...References1. McDonald CJ. Medical heuristics: the silent adjudicators of clinical practice. Ann Intern Med. 1996; 124:56-62. Google Scholar2. Rytand DA. Sutton's or Dock's Law? [Letter] N Engl J Med. 1980; 302:972. Google Scholar3. Petersdorf RG, Beeson PB. Fever of unexplained origin: report on 100 cases. Medicine (Baltimore). 1961; 40:1-30. Google Scholar Author, Article, and Disclosure InformationAffiliations: State University of New York Health Science Center at Brooklyn, Brooklyn, NY 11203 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoMedical Heuristics: The Silent Adjudicators of Clinical Practice Clement J. McDonald Medical Heuristics: The Silent Adjudicators of Clinical Practice Clement J. McDonald Medical Heuristics William J. Oetgen Metrics Cited ByCavitation-jet deinking: A new technology for deinking of recovered paperEffects of ultrasonic wave pretreatment on the fibrillation of cellulose fiber 1 July 1996Volume 125, Issue 1Page: 78KeywordsBiopsyFearLiverPathologistsSchistosomiasis Issue Published: 1 July 1996 CopyrightCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Effect of stored-blood transfusion on oxygen delivery in patients with sepsis
Authors: P. E. Marik
Journal: JAMA (1993)

<h3>Background.</h3> —Red blood cell transfusion is commonly used to augment systemic oxygen delivery to supranormal levels in patients with sepsis. However, clinical studies have not consistently demonstrated that this therapeutic maneuver is accompanied by an increase in oxygen utilization at either the whole-body level or within individual organs. <h3>Study Objectives.</h3> —To determine the effect of red blood cell transfusion on gastrointestinal and whole-body oxygen uptake. <h3>Design.</h3> —Prospective, controlled, interventional study. <h3>Setting.</h3> —Multidisciplinary intensive care unit of a tertiary care teaching hospital. <h3>Patients.</h3> —Twenty-three critically ill patients with sepsis undergoing mechanical ventilation. <h3>Measurements and Main Results.</h3> —Systemic oxygen uptake was measured by indirect calorimetry and calculated by the Fick method. Gastric intramucosal pH as measured by tonometry was used to assess changes in splanchnic oxygen availability. Measurements were made prior to transfusion of 3 U of packed red blood cells. These were then repeated immediately following transfusion, as well as 3 and 6 hours later. There was no increase in systemic oxygen uptake measured by indirect calorimetry in any of the patients studied for up to 6 hours posttransfusion (including those patients with an elevated arterial lactate concentration). However, the calculated systemic oxygen uptake increased in parallel with the oxygen delivery in all the patients. More importantly, we found an inverse association between the change in gastric intramucosal pH and the age of the transfused blood (<i>r</i>=-.71;<i>P</i>&lt;.001). In those patients receiving blood that had been stored for more than 15 days, the gastric intramucosal pH consistently decreased following the red blood cell transfusion. <h3>Conclusion.</h3> —We failed to demonstrate a beneficial effect of red blood cell transfusion on measured systemic oxygen uptake in patients with sepsis. Patients receiving old transfused red blood cells developed evidence of splanchnic ischemia. We postulate that the poorly deformable transfused red blood cells cause microcirculatory occlusion in some organs, which may lead to tissue ischemia in some organs. (<i>JAMA</i>. 1993;269:3024-3029)
Calcific tendinitis and soft-tissue calcification resembling gout
Authors: G. R. Thompson
Journal: JAMA (1968)

Eight cases have been evaluated in which calcific tendinitis presented as acute monarticular arthritis closely resembling acute gout. In each, soft-tissue calcification in the area of maximum tenderness was demonstrated. All had normal serum uric acid levels. Five of the individuals responded dramatically to colchicine therapy; the other three improved following treatment with phenylbutazone or oxyphenylbutazone. Another patient with uremia, who was undergoing hemodialysis, had extensive soft-tissue calcifications associated with acute inflammation also responsive to colchicine. The calcified material in this patient and in one of the patients with calcific tendinitis was found to be hydroxyapatite.
The shifting social scene and family medicine
Authors: J. L. Dennis
Journal: JAMA (1968)

Although by nature physicians are conservative, all of them in the past 30 years have accepted radical changes. For example, in 1930 there was no government involvement in medicine; today, virtually every physician collaborates with government in one way or another. In 1930 general practitioners in private practice dominated the field and were to be found in every community; today, specialists predominate and are concentrated around major medical centers in large cities and the affluent suburbs, while in the central cores of our metropolitan areas and in many rural communities, physicians are no longer available. In 1930 practice was almost exclusively devoted to acute infectious and contagious disease, infant and maternal mortality, and emergency surgery because the primary concern was the prevention of death; today, the concern is the prevention of illness, health care, chronic and degenerative disease, stress disorders, trauma, and major elective and corrective surgery. In 1930 medical
P2.01-43 ADSCaN: A Randomised Phase II Study of Accelerated, Dose Escalated, Sequential Chemo-Radiotherapy in Non-Small Cell Lung Cancer (NSCLC)
Authors: C. Lawless, M. Hatton, C. Faivre-Finn, D. Landau, K. Boyd, J. Fenwick, J. Lester, E. Mccartney, J. Paul, A. Shaw, R. Simoes
Journal: Journal of Thoracic Oncology (2018)
Ultrastructural and Biochemical Effects of Prolonged Oral Arsenic Exposure on Liver Mitochondria of Rats
Authors: Bruce A. Fowler, James S. Woods, Carol M. Schiller
Journal: Environmental Health Perspectives (1977)

This investigation was undertaken to further delineate the subcellular manifestations of arsenic toxicity following chronic exposure using combined ultrastructural and biochemical techniques. Male rats were given access to deionized drinking water solutions containing 0, 20, 40, or 85 arsenic as arsenate (As+5) for 6 weeks. In situ swelling of liver mitochondria was the most prominent ultrastructural change observed. Mitochondrial respiration studies indicated decreased state 3 respiration and respiratory control ratios (RCR) for pyruvate/malate but not succinate mediated respiration. Specific activity of monoamine oxidase which is localized on the outer mitochondrial membrane showed increases of up to 150% of control and cytochrome-C oxidase which is localized on the inner mitochondrial membrane showed increases in specific activity of 150–200%. Activity of malate dehydrogenase which is localized in the mitochondrial matrix was unchanged at any dose level. These studies indicate that decreased mitochondrial respiration is only one aspect of arsenic toxicity to this organelle. Marked arsenic-mediated perturbation of important enzyme systems localized in mitochondria which participate in the control of respiration and other normal mitochondrial functions are also important manifestations of cellular dysfunction.
Lolly Rash?
Authors: J. B. Traherne
Journal: BMJ (1961)

<h3>ABSTRACT</h3> Climate variability is the most important force affecting distributional range dynamics of common and widespread species with important impacts on biogeographic patterns. This study integrates phylogeography with distributional analyses to understand the demographic history and range dynamics of a widespread bird species, the Ruffed Grouse (<i>Bonasa umbellus</i>), under several climate change scenarios. For this, I used an ecological niche modelling approach, together with Bayesian based phylogeographic analysis and landscape genetics, to develop robust inferences regarding this species’ demographic history and range dynamics. The model’s predictions were mostly congruent with the present distribution of the Ruffed Grouse. However, under the Last Glacial Maximum bioclimatic conditions, the model predicted a substantially narrower distribution than the present. The predictions for the Last Glacial Maximum also showed three allopatric refugia in south-eastern and west-coast North America, and a cryptic refugium in Alaska. The prediction for the Last Interglacial showed two separate distributions to the west and east of the Rocky Mountains. In addition, the predictions for 2050 and 2070 indicated that the Ruffed Grouse will most likely show slight range shifts to the north and will become more widely distributed than in the past or present. At present, effective population connectivity throughout North America was weakly positively correlated with F<sub><i>st</i></sub> values. That is, the species’ distribution range showed a weak isolation-by-resistance pattern. The extended Bayesian Skyline Plot analysis, which provided good resolution of the effective population size changes over the Ruffed Grouse’s history, was mostly congruent with ecological niche modelling predictions for this species. This study offers the first investigation of the late-Quaternary history of the Ruffed Grouse based on ecological niche modelling and Bayesian based demographic analysis. The species’ present genetic structure is significantly affected by past climate changes, particularly during the last 130 kybp. That is, this study offers valuable evidence of the ‘expansion–contraction’ model of North America’s Pleistocene biogeography.
Retrospective Address of the Pathological Society of Reading
Authors: W. Royds
Journal: BMJ (1871)

With the usual candour for which the Society is so deeply indebted to Mr. Walford, he brought forward some of his unsuccessful cases.Intrauterine Cancer: ffimorrhage.-Thefirst was a patient, in her thirty-fourth year, whom he had attended in several confinements, and for whom he had more than once to remove the placenta by the hand.In August, 1870, he again saw her, with threatening of miscarriage at the fourth month.On account of a shivering fit and quickened pulse, he thought it right to empty the uterus, which he did on the Ist of September.On the 7th, heemorrhage took place, requirng the introduction of a plug This was removed on the 8th, and she seemed on the road to recovery; but the same night the sponge, which he used as a plug, had to be replaced.Haemorrhage, nevertheless, continued to some extent, and the patient sank and died on the gth.The condition, as revealed by a /iost morteem examination, seemed to Mr. Walford to justify his returning the cause of death as "cancer of the mucous membrane of the uterus and hcemorrhage."Abortion.-Anothercase of Mr. Walford's was an abortion at six weeks in a woman aged 41, the mother of eight children, who had been accustomed to nurse her children two years.The ovum, with its
Use of Mammography Services by Women Aged ≥65 Years Enrolled in Medicare— United States, 1991-1993
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Violence: An Unrecognized Environmental Exposure That May Contribute to Greater Asthma Morbidity in High Risk Inner-City Populations
Authors: Rosalind J. Wright, Suzanne F. Steinbach
Journal: Environmental Health Perspectives (2001)

In the United States, rising trends in asthma prevalence and severity, which disproportionately impact minorities and the urban poor, have not been fully explained by traditional physical environmental risk factors. Exigencies of inner-city living can increase psychosocial risk factors (e.g., stress) that confer increased asthma morbidity. In the United States, chronic exposure to violence is a unique stressor existing in many high-risk urban neighborhoods. In this paper, we describe a series of cases that exemplify a temporal association between exposure to violence and the precipitation of asthma exacerbations in four urban pediatric patients. In the first three cases, the nature of the exposure is characterized by the proximity to violence, which ranged from direct victimization (through either the threat of physical assault or actual assault) to learning of the death of a peer. The fourth case characterizes a scenario in which a child was exposed to severe parental conflict (i.e., domestic violence) in the hospital setting. Increasingly, studies have begun to explore the effect of living in a violent environment, with a chronic pervasive atmosphere of fear and the perceived or real threat of violence, on health outcomes in population-based studies. Violence exposure may contribute to environmental demands that tax both the individual and the communities in which they live to impact the inner-city asthma burden. At the individual level, intervention strategies aimed to reduce violence exposure, to reduce stress, or to counsel victims or witnesses to violence may be complementary to more traditional asthma treatment in these populations. Change in policies that address the social, economic, and political factors that contribute to crime and violence in urban America may have broader impact.
BUREAU OF LEGAL MEDICINE AND LEGISLATION
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal