tbuckley/cabot-search huggingface dataset:
Nursing Homes Need Improved Antibiotic Stewardship
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
P1.04-81 Characterization of Hispanic Patients Who Experienced Hyperprogression During Treatment for Advanced NSCLC with Immunotherapy
Authors: O.G. Arrieta, A. Ruiz-Patiño, A.F. Cardona, C. Martin, L. Raez, Z.L. Zatarain Barrón, F. Barrón, L. Ricaurte, M.A. Bravo-Garzón, L. Mas, L. Corrales, L.L. Rojas, L. Lupinacci, F. Perazzo, C. Bas, O. Carranza, C. Puparelli, M. Rizzo, R. Ruiz, C. Rolfo, P. Archila, J. Rodriguez, C. Sotelo, C. Vargas, H. Carranza, J. Otero, L. Pino, C. Ortiz, P. Laguado, R. Rosell
Journal: Journal of Thoracic Oncology (2019)
ANTISTREPTOCOCCIC SERUM.
Authors: C. P. THOMAS
Journal: JAMA (1899)

I contributed to theJournalof Dec. 18, 1897, a report of eight cases of acute sepsis in which I had used Marmorek's antistreptococcic serum with complete success, and I now have fifteen more cases to report. <h3>Case 9.</h3> - Mr. J., age 50, was suffering from acute gangrene of the lung following pneumonia. His breath was extremely fetid, temperature 101; the entire body covered with an eruption, appetite poor, and he was apparently in a hopeless condition. Phthisis was suspected; two microscopic examinations failed to detect tubercle bacilli, but confirmed the diagnosis of gangrene of the lung. This condition having continued for several days without any apparent improvement, he was given 10 c.c. of serum, and in twenty-four hours his temperature and pulse were normal, the odor of the breath less offensive, and the eruption disappearing. His condition continued to improve until the tenth day, when he left the hospital
Pediatrics, Evanston, Ill
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Massachusetts Medical Society
Authors: Mark Falcon Lesses, Roderick C. Dwyer
Journal: New England Journal of Medicine (1959)

THE PLASMA-SALVAGE PROGRAM OF THE SUPERVISORY COMMITTEE ON BLOOD BANKS OF THE MASSACHUSETTS MEDICAL SOCIETY AND THE MASSACHUSETTS DEPARTMENT OF PUBLIC HEALTHIn May, 1954, the Supervisory Committee on Blood Banks of the Massachusetts Medical Society established a plasma-salvage program in co-operation with the Institute of Laboratories of the Massachusetts Department of Public Health, which has served as the processing agency. This program was designed to conserve the plasma from outdated blood that might otherwise have been discarded, since most hospital blood banks are not equipped to fractionate.The Institute has processed most of this plasma into salt-poor albumin and . . .
Estrogen-like activity of digitalis: its effect on the squamous epithelium of the female genital tract
Authors: A. Navab
Journal: JAMA (1965)

Vaginal smears of 52 postmenopausal women who had been taking digitoxin for periods of three months to 15 years were studied for possible estrogen-like effect on epithelial maturation. The pattern of cells from 20 women who had been taking digitoxin for over two years showed marked maturation of vaginal squamous epithelium, closely simulating the effect of estrogens. Of the 32 women who had been taking digitoxin less than two years, only three showed marked maturation of the squamous epithelium. Four of the 50 control patients exhibited moderate estrogenic effect. None showed marked maturation of vaginal epithelium.
Abstract 189: Natural History of Coronary Artery Aneurysms in Kawasaki Disease in US population and Risk Factors for Persistent Aneurysms
Authors: Kevin G Friedman, Akiko Hamaoko-Okamoto, Kimberly Gauvreau, Sarah de Ferranti, Annette Baker, David Fulton, Adriana Tremoulet, Alexander Tang, Erika Berry, Vidya S Mahavadi, Jane Burns, Jane Newburger
Journal: Circulation (2015)

Background: The late natural history of coronary artery aneurysms (CAA) after IVIG treatment in the US is not well described. Methods: We evaluated all KD patients (pts) at 2 centers from 1984-2014. Entry criteria were: 1) IVIG treatment; 2) CAA, defined as LAD or RCA z-score ≥ 3 or Japanese Ministry of Health criteria; and 3) ≥1 follow-up (f/u) echo. Kaplan Meier curves evaluated time to CAA regression (z &lt; 2.5) and Cox regression examined factors associated with persistent CAA and major adverse cardiac events (MACE= death, MI, CABG, PCI, occluded CA). Results: Of 2592 KD pts, 408 (15%) met entry criteria and were 72% male; 54% white, 21% Asian, 7% black, 18% other race. Median age at fever onset was 1.8 y [IQR: 0.7-4.4y], 74% had complete KD, and fever days before 1 st IVIG were 7d [IQR 6-10d]. IVIG retreatment occurred in 35% and adjunctive anti-inflammatory therapy in 37%, both increased over time (p&lt;.001). LAD and RCA CAA occurred in 31%, LAD alone in 47% and RCA alone in 22%. Median z-scores at CAA diagnosis were: LAD 3.61 (IQR 3.1-5.1) and RCA 3.1 (1.7-4.1) with 93 (23%) pts having giant CAA (z ≥10). Over median f/u of 2.6 y (0.01-29.0y), 313 (77%) had CAA regression at median of 1.1 mo (IQR =0.3-16.9mo). Univariate risk factors for CAA persistence were z ≥ 8 at diagnosis (HR 0.22, p &lt;.001), earlier era (2010-2014 HR =1.0 , 2000-2009 HR = 0.60, 1990-1999 HR =0.38, 1984-1989=0.15, all p&lt;.001), multi-vessel CAA (LCA alone HR =1, RCA alone HR =0.99 p=.99, LCA+RCA HR=0.35, p&lt;.001) IVIG retreatment (HR 0.68, p=.003), IVIG treatment &gt;Day 10 (HR 0.46, p&lt;0.001), adjunctive anti-inflammatory therapy (HR 0.65, p=.03), and non-Asian race (HR 0.64, p=.001). Multivariable model for persistent CAA included earlier era (p&lt;.001), z-score &gt;8 at diagnosis (p&lt;.001), multi-vessel CAA (&lt;.001) and treatment after Day 10 (p=.01). MACE occurred in 25 (1%) pts, including 3 deaths, with univariate risk factors of CAA z-score ≥ 8 (p&lt;.001), earlier era (p&lt;.001), treatment after 10 d (p=.03), and non-Asian race (p=.03) Conclusion: Most CAA regress within the first year after treatment. Persistent CAA are more likely in pts with larger CAA, multi-vessel CAA and late IVIG treatment. In pts with large CAA, time to regression has gotten shorter in more recent eras, possibly related to greater use of adjunctive therapies.
FOURTH OF JULY CASUALTIES.
Journal: JAMA (1887)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fatty Acid Composition of Brain Lecithins in Multiple Sclerosis
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Missing Reference
Journal: JAMA Pediatrics (2017)

Incorrect Sample Size in a Table : In the Original Investigation titled "Differencein-Differences Analysis of the Association Between State Same-Sex Marriage Policies and Adolescent Suicide Attempts," published in the April issue of JAMA Pediatrics, 1 an incorrect sample size appeared in Table 2.In the first column of that table, the sample size for all students, which was given as 765 039, should be replaced with 762 678.This article was corrected online.
The risk of breast cancer in postmenopausal women who have used estrogen replacement therapy
Authors: P. A. Wingo
Journal: JAMA (1987)

We studied the association between estrogen replacement therapy (ERT) and the risk of breast cancer as part of the Cancer and Steroid Hormone Study. All subjects in the analysis were postmenopausal women enrolled from eight geographic areas. Women 25 to 54 years old with newly diagnosed breast cancer were identified through population-based tumor registries and diagnosed between Dec 1,1980, and Dec 31,1982. Controls were selected from the same eight geographic areas by the random digit dialing of residential telephone numbers. Analyses included 1369 cases and 1645 controls. Among women with bilateral oophorectomy, the relative risk of breast cancer for women who had ever used ERT was 1.3, compared with women who had never used ERT. Among women who had undergone hysterectomy but who still had at least one ovary, the relative risk was 1.1; among women who reported a natural menopause, the relative risk was 0.8. Overall, the risk of breast cancer did not appear to increase appreciably with increasing ERT duration or latency, even for durations and latencies of 20 years or longer. (<i>JAMA</i>1987;257:209-215)
Assessing distress in patients with gastrointestinal tumors during radiotherapy.
Authors: Laeticia Hollant, Megan Paige Single, Katherine Gaines, Bridget Smart, Jacob Habboush, Tasneem Kaleem, Katherine S. Tzou, Stephen Ko, Heather Biers, Atiya Day, Byron C. May, Robert Clell Miller
Journal: Journal of Clinical Oncology (2016)

e18087 Background: Psychosocial distress during radiotherapy (RT) for gastrointestinal tumors is poorly characterized. Since 2012, patients receiving RT in our clinic have been prospectively screened for causes of distress. The results of our screening were reviewed in order to elucidate concerns of GI cancer patients and to delineate patterns within patient reported distress (PRD). Methods: Patients treated with RT at our institution receive a 30 question PRD survey that also includes a linear analog measure of overall distress at the start and during RT. The PRD survey asks patients to rate forms of distress on a scale of 1 to 5 (5 being the most distressed). The survey also asks patients to rate overall distress according to the National Comprehensive Cancer Network (NCCN) Distress Thermometer on a scale 0 to 10. The reported results were retrospectively reviewed in patients receiving definitive RT for GI cancers from 04/02/2012 to 08/05/2015. Results: PRD surveys were completed by 113 patients, 55 (48.7%) male and 58 (51.3%) female. Median age was 65 years (range 28 to 93). The most common tumor histology was adenocarcinoma, 67 (59.3%). 105 patients (93.0%) received chemotherapy and 66 (58.4%) underwent surgery. Overall, NCCN distress thermometer results ranged from 0 to 10, with a median of 4.3. The mean distress scores for the top five complaints ranged from 1.27 to 2.63. Top distresses were "How will I feel during treatment" (2.63), "Fatigue" (2.45), "Pain that affects daily functioning" (2.35), "Out of pocket medical costs" (2.31), and "Sleep difficulties" (2.31). The least concerning complaints were "Housing during treatment" (1.27), "A loved one relying on me for their physical care" (1.30), "Spirituality" (1.33),"Family communication about my illness"(1.37), and "Transportation" (1.38). Conclusions: Patients' major concerns were aligned with daily quality of life, such as fatigue, pain and insomnia. Highest reported distress was linked with the process of RT and side effects associated with treatment. Medical expenses were also perceived as a burden. Medical providers should identify psychosocial stressors during RT in order to effectively communicate and provide resources to improve quality of life.
Why does the Operation for the Cure of Strabismus Sometimes Fail?
Authors: C. Holthouse
Journal: BMJ (1858)

IN a former number of this JOURNAL (May 20th), I stated that many surgeons regarded the operation for strabismus as so uncertain, that they advised their patients not to submit to it.This opinion may be correct when the operation is undertaken by unpractised or unskilful hands; but, under opposite cir- cumstances, it is far from the truth.Nevertheless, failures do sometimes occur, even in the hands of the most skilful; and the causes of these, I shall endeavour to point out.
ATIM-10. PHASE 2 TRIAL OF SL-701, A NOVEL IMMUNOTHERAPY COMPRISED OF SYNTHETIC SHORT PEPTIDES AGAINST GBM TARGETS IL-13Rα2, EphA2, AND SURVIVIN, IN ADULTS WITH SECOND-LINE RECURRENT GBM
Authors: David Reardon, Burt Nabors, Priya Kumthekar, Michael Badruddoja, Karen Fink, Frank Lieberman, Jethro Hu, Erin Dunbar, Tobias Walbert, David Schiff, Jonathan Sherman, David Tran, Lynn S Ashby, Nicholas Butowski, Fabio Iwamoto, Christopher Moertel, Michael Schulder, Janice Chen, John Bullington, Shay Shemesh, Christopher Brooks, Trishna Goswami, David M Peereboom
Journal: Neuro-Oncology (2017)

SL-701, a novel immunotherapy comprised of synthetic peptides elicits immune responses against overexpressed GBM targets: interleukin-13 receptor alpha-2 (IL-13Rα2), EphrinA2 (EphA2), and Survivin. Updated data reported from a multicenter, 2-stage Phase 2 clinical trial of SL-701 in HLA-A2+ adults with relapsed GBM. Patients enrolled had KPS > 60 and failure of standard RT/TMZ. Stage 1: SL-701 was administered with adjuvants GM-CSF and imiquimod biweekly for 6 months, then q28 days. Stage 2: SL-701 and adjuvant poly-ICLC were administered biweekly with bevacizumab (10 mg/kg). Primary objectives include: safety and tolerability, investigator assessed objective response rate (ORR) using RANO criteria and 12 month-survival rate. As of 16May2017, 74 patients (46 in Stage 1 and 28 in Stage 2) received SL-701. Accrual for Stage 1 and 2 is complete. Patients were 100% bevacizumab naïve, 65% male with a median age of 56 years (range: 24–79). Patients received a median of 8.5 doses. The most frequent grade 3–4 treatment-related adverse event was fatigue (n = 2; 2.7%). Among 46 evaluable Stage 1 patients, 1 partial response (PR; duration: 78 weeks) and 15 stable disease (SD; median duration: 16 weeks; range: 1.3 – 99 weeks) were observed. Of 28 evaluable Stage 2 patients, 21% ORR consisting of 2 complete response (CR; duration: 30 and 46 weeks, respectively) and 4 PR (median duration: 31 weeks; range: 12 – 47 weeks) was observed with 19 SD (median duration: 14 weeks; range: 0.1 - 41 weeks) achieved. Median overall survival (mOS) of 11.2 and 11.7 months was observed for Stage 1 and 2 patients, respectively with a 25% survival probability at 14 weeks. SL-701 plus adjuvants with or without bevacizumab have a manageable safety profile with anti-tumor activity, several CRs, and a preliminarily promising survival curve, warranting further study. Updated study data will be presented.
Allied Medical Education—1973 Annual Report
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
STEM-12. INCREASING INDUCED NEURAL STEM CELL PERSISTENCE IN THE TUMOR RESECTION CAVITY
Authors: Hunter Bomba, Kevin Sheets, Abigail Carey-Ewend, Morgan Goetz, Juli Bago, Simon Khagi, Shawn Hingtgen
Journal: Neuro-Oncology (2019)

Abstract Glioblastoma multiforme (GBM) is the most common primary brain cancer in adults. Afflicted patients have a median survival rate of only 15 months, and patient survival statistics have remained stagnant for over three decades. Current standard of care includes maximal safe tumor resection, chemotherapy, and radiation. Nevertheless, GBM is aggressive, making recurrence and deeper tumor infiltration inevitable. Neural stem cells transdifferentiated from a skin biopsy, i.e. induced neural stem cells (iNSCs), have the innate ability to home to tumors, and, when engineered with cytotoxic proteins, can actively kill cancer cells. However, direct injection of these cells into the hostile immune environment of the tumor resection cavity results in an accelerated clearance rate and therefore a shortened therapeutic window. To combat this clearance issue, we investigated the FDA-approved hemostatic matrix, Floseal, as a cell delivery platform to increase iNSC persistence. In vitro, SEM imaging showed homogeneous iNSC distribution throughout Floseal. Using our surgical resection model of GBM in mice, we delivered iNSCs into the post-surgical cavity in Floseal and by direct injection to model current clinical delivery strategies. Serial kinetic imaging showed that human iNSC persistence delivered into the cavity in Floseal persisted over 90 days, while cells directly injected into the brain parenchyma persist less than 20 days. When we investigated the impact on tumor kill, we found the increase in persistence increased survival of GBM-bearing mice more than 30 days compared to control cells. Light-sheet microscopy showed wild-type neural stem cells migrate into invasive GBM-8 tumors in the contralateral hemisphere, and we are now using this approach to validate the homing of iNSCs delivered via Floseal. Administration of iNSCs encapsulated in the biocompatible Floseal matrix offers a promising, clinically-translatable therapeutic strategy for GBM.
Abstracts
Journal: Annals of the Rheumatic Diseases (1972)

One hundred regular hospital attenders with rheumatoid arthritis were studied clinically and radiologically with a view to establishing the incidence and effects of atlanto- axial subluxation and of cervical myelopathy.On the basis of atlanto-odontoid separation of 3 mm.or more on lateral tomography in flexion a diagnosis of subluxation was made in 36 patients. 24of these 36 patients had clinical evidence of pyramidal-tract disease, but similar signs were present in 10 patients without subluxation.The known association of subluxation with severe peripheral deformity was confirmed.Neck pain was no more common in patients with subluxation than in the remainder of the group.[The paper is of current interest and contains a verbose preamble dealing with the atlanto-axial joint and its pathology.It does not, however, give much new in- formation; in particular the study was not designed to throw any light on natural history, prognosis, and man- agement, where data are really needed].
The parents' journey: continuing a pregnancy after a diagnosis of Patau's syndrome
Journal: BMJ (2005)

the dose rather than the recommended dose was associated with more diarrhoea (incidence rate ratio 1.14, 1.01 to 1.28), fever (1.09, 0.99 to 1.20), and consultations at a hospital or health centre (1.10, 0.95 to 1.27).This tendency was similar in boys and girls.The 1494 children who were at home at the nine month follow-up visit had their mid-upper arm circumference measured.There was no difference between those who received full versus half the recommended dose in boys or girls.Likewise using data from the routine registration of children < 3 years, there was no difference in mid-upper arm circumference related to the different doses of vitamin A.