tbuckley/cabot-search huggingface dataset:
Abstract 18100: Community-Based, Targeted CPR Education to Improve Survival From Out-of-hospital Cardiac Arrest in Tampa’s High-risk Neighborhoods
Authors: Jennifer Waxler, Ashish Panchal, Ronnie Rivera, Marina Del Rios, Nacole Revette, Maja Magazin, Deanna Hogue, Debra Heard, Comilla Sasson
Journal: Circulation (2015)

Introduction: The Hands-Only CPR™ Program is a novel intervention designed to target high-risk neighborhoods (where the incidence of cardiac arrest is high and bystander CPR rates are low) to increase CPR performance. The program has been successfully implemented in pilot projects, however, the feasibility of implementing this program in additional communities is unknown. Objective: Conduct a feasibility study of a community-based Hands-Only CPR program in Tampa’s high-risk neighborhoods. Methods: Population: Convenience sample of 740 participants were recruited from target neighborhoods during a 16-week study period. Intervention: Participants completed a pre-test survey to for baseline CPR knowledge followed by a group Hands-Only CPR training (1 hour) conducted with the CPR Anytime kit, which includes an educational DVD and hands-on practical skills training with a manikin. Participants then completed a survey to assess their post-training knowledge and were asked to use the kits to train others. A $10 gift card incentive was given to participants once follow-up information was returned. Results: Participants were a mean age of 46.6 years, White (41.9%), Hispanic/Latino (37.6%), female (67.7%), had completed high school or above (82.6%), and had an annual income of less than $30,000 (35.8%) (Table 1). After the CPR intervention, the mean number of questions answered correctly on CPR knowledge increased. The majority of participants (81.1%) felt comfortable performing Hands-Only CPR after the intervention. 580 completed the pre- and post-tests. Of these 580, 37 (6.4%) participants returned information, with an additional 137 friends and family trained. Conclusion: The Hands-Only CPR Program is a novel method to increase the knowledge of CPR and comfort performing CPR in a target population. Additional studies will need to be conducted to test this intervention in other communities as well as its overall effect on bystander CPR rates.
Vitamin B12 deficiency and early rise in mean corpuscular volume
Authors: C. A. Hall
Journal: JAMA (1981)

An increase in the mean corpuscular volume (MCV), while not diagnostic of vitamin B<sub>12</sub>or folate deficiency, is a valuable, readily available screening test. I discuss six instances where an increased MCV was recorded months prior to diagnosis and could, if noted, have led to an earlier diagnosis. (<i>JAMA</i>1981;245:1144-1146)
MEDICAL PREPAREDNESS
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstracts
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Alternatives to adolescent drug abuse
Authors: S. Cohen
Journal: JAMA (1977)

SUBSTANCE abuse can be thought of as a maladaptive response to personal and interpersonal difficulties in which drug overuse becomes a way of life preferable to the actual life situation. The life situation may really be chaotic and hopeless or boring and meaningless, or it may simply be perceived to be so by the young person. At any rate, life goals, rewarding activities, the ability to enjoy and look ahead to a fulfilling future do not exist. To provide alternative options to a life-style of drug dependence, the substitute activities ought to be pleasure-giving or be significant now or in the foreseeable future. The principle of providing alternatives to drug abuse has been summarized as follows: "Major inroads on drug abuse cannot be made by stressing the undesirability of drugs. It can only be done by offering more desirable alternative involvements—activities, life-styles and satisfactions which are more rewarding than drug
Pembrolizumab OK'd for Cervical Cancer
Journal: Cancer Discovery (2018)

The FDA approved the PD-1 inhibitor pembrolizumab as a second-line treatment for patients with recurrent or metastatic cervical cancer who expressed PD-L1 with a combined positive score of at least 1. The approval was based on results of a phase II trial in which patients treated with the drug had an objective response rate of 14.3%.
Handbook for the Hospital Corps of the U. S. Army and State Military Forces.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bone marrow transplantation for acute myeloblastic leukemia
Authors: M. M. Bortin
Journal: JAMA (1978)

Fifty-seven patients with end-stage acute myeloblastic leukemia (AML) received a total of 65 bone marrow transplants between 1968 and 1976. Marrow from HLA genotypically identical allogeneic donors was administered to 32 patients, 13 received marrow from HLA-incompatible donors, donorrecipient HLA compatibility was undetermined for eight patients, and identical twins were marrow donors for four patients. None of the patients in the three latter groups survived beyond 9.4 months after transplantation. Two patients treated with marrow transplants from HLA-compatible donors currently are alive and free of leukemia with functioning grafts 13 and 38 months after transplantation. The 32 patients in the Registry series who received marrow from HLA-compatible donors were compared with a similar series of 46 patients in Seattle. Data for these 78 patients were pooled and analyzed for pretransplant factors that might have prognostic value. Patients with end-stage AML had approximately a 10% chance of surviving 20 months after high-dose chemoradiotherapy plus marrow transplantation. Patients younger than 21 years had a higher six-month survival rate than patients older than 30 years. Patients in the Registry series who received transplants with HLA-compatible marrow within eight months of diagnosis had a higher survival experience than patients who received transplants later. (<i>JAMA</i>240:1245-1252, 1978)
Risk assessment, management addressed at 'Prevention 85'
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The four-legged stool. Community participation, community medicine, and the community hospital
Authors: S. Reichman
Journal: JAMA (1972)

Seven prerequisites are suggested for successful community involvement in health care programs at community hospitals. Initially, there should be a communicated understanding that willingness to change exists. Second, an actual demonstrated change should begin. Third, a mechanism for community participation in this change should be developed. Fourth, an organized formal department with stated objectives and authority should be formed. Next, the hospital services must recognize principles of an interrelating partnership with this new department. Sixth, provision for educational and research activities must be defined. Experiences with these principles in the organization and formation of a department of community medicine are described resulting in the final requirement of a partnership of professional staff, the institution, and the community.
Manuscripts Approved for JNCI, May 10 to June 10, 1963
Journal: JNCI Journal of the National Cancer Institute (1963)

Manuscripts Approved for JNCI, May 10 to June 10, 1963 Get access JNCI: Journal of the National Cancer Institute, Volume 31, Issue 1, July 1963, Pages 197–198, https://doi.org/10.1093/jnci/31.1.197 Published: 01 July 1963
The Cover
Authors: Judith Leet
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Rituximab Maintenance Treatment For a Maximum Of 5 Years In Follicular Lymphoma: Results Of The Randomized Phase III Trial SAKK 35/03
Authors: Christian J. Taverna, Giovanni Martinelli, Felicitas Hitz, Walter Mingrone, Thomas Pabst, Lidija Cevreska, Auro del Giglio, Anna Vanazzi, Daniele Laszlo, Johann Raats, Daniel Rauch, Daniel A. Vorobiof, Andreas Lohri, Emanuele Zucca, Christine Biaggi Rudolf, Stephanie Rondeau, Corinne Rusterholz, Michele Ghielmini
Journal: Blood (2013)
STMC-01. NANOPARTICLE DELIVERY OF miRNAs TO INHIBIT GBM STEM CELLS
Authors: Hernando Lopez-Bertoni
Journal: Neuro-Oncology (2016)

Cancer cells arise from multiple complementary genomic and epigenomic abnormalities that deregulate pathways that control cell proliferation and tissue homeostasis. Epigenetic modifications, involving deregulation of non-coding RNAs, are emerging as critical determinants of gene expression and essential drivers of neoplastic phenotypes. Our knowledge of how these complex epigenetic mechanisms operate in the context of cancer cell phenotype regulation remains limited. Non-coding RNAs, in particular miRNAs, are emerging as critical epigenetic regulators of cell fate and oncogenesis. MiRNAs act by selectively inhibiting gene expression primarily by targeting mRNA for degradation usually via complementary 3’-UTR seed sequences. Numerous miRNAs have been found to regulate tumorigenesis and cancer cell stemness by virtue of their capacity to target tumor-suppressing or tumor promoting transcripts. We recently showed that the coordinated actions of Oct4 and Sox2 induce a tumor-propagating stem-like state in GBM cells through a mechanism that involves the induction of DNMTs and down-regulation of a network of miRNAs through promoter DNA methylation. Two of the miRNAs repressed by Oct4/Sox2, miR-148a and miR-296-5p, efficiently inhibit the tumor propagating capacity of GBM stem-like, making them excellent candidates for therapeutic intervention. Recent developments in nanomedicine provide new and exciting opportunities to treat and manage brain tumors. Cationic polymers are a class of biomaterials with great promise for targeted molecular therapeutics. We combined this cutting-edge technology with our newly discovered stem cell inhibiting miRNAs to develop nano/miR conjugates to treat gliomas. We show these nano/miR conjugates distribute throughout an established tumor in vivo, and more importantly, delivering these tumor-suppressing miRNAs using PBAE polymers inhibits the growth of established GBM tumor in mouse models. Our findings demonstrate that identifying and validating stem cell-inhibitory in combination with current advances in nanomedicine will undoubtedly impact the development of novel therapies for targeting the CSC population and treating GBM.
Plague and pregnancy. A case report
Authors: J. M. Mann
Journal: JAMA (1977)

PLAGUE, like other severe systemic illnesses acquired during pregnancy, may cause spontaneous abortion.<sup>1</sup>In his comprehensive review of plague, Pollitzer<sup>2</sup>noted, "Unless specific treatment is started early, serious attacks of plague in any form usually lead to abortion or miscarriage in pregnant patients, events which exert a most unfavorable influence on the outcome of the illness." Descriptions of plague during pregnancy are principally derived from the preantibiotic era.<sup>1,2</sup>This communication describes a case of bubonic plague that occurred in a pregnant woman from Santa Fe, NM, during the 1975 plague season. <h3>Report of a Case</h3> A 28-year-old woman in her fifth month of pregnancy was examined by one of us (R.M.) at a Santa Fe hospital on Sept 15, 1975; her chief complaints were chills, fever, and a painful right inguinal swelling of 12 hours' duration. The patient and her family had recently moved into a house
Survey of health professionals' information habits and needs. Conducted through personal interviews
Authors: E. R. Stinson
Journal: JAMA (1980)

Interviews with 402 randomly selected health professionals identified the information habits health professionals used to stay abreast of current advances in medicine. The use of various information sources was related to such factors as their type of practice, specialty, location of practice, professional's age, and the size of their primary hospital. In addition to medical literature, the most common source, the typical responder spent one to five hours each week in discussions with colleagues. He or she also spent five to ten hours each year at local professional meetings, five to ten hours per year at state meetings, ten to 15 hours per year at national meetings, and ten to 15 hours per year at educational courses sponsored by various medical schools. Unsolicited medical literature was used extensively, particularly by those in rural, solo practice. (<i>JAMA</i>243:140-143, 1980)
The effect of brachytherapy on restenosis at 6 months after angioplasty of the lower limb arteries: An intermediate analysis Agostino Faggiotto, Andreas Blatter, Michael Llamas, Jeanne-Marie Segatto, Felix Mahler, Kurt Jaeger, Luca Cozzi, Jacques Bernier, Augusto F. Gallino. Augusto Gallino, Bellinzona, Switzerland
Journal: Journal of the American College of Cardiology (2001)
Journal of Bone and Joint Surgery, Boston
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction facility TB rates soar; some jails bring back chest roentgenograms
Authors: A. A. Skolnick
Journal: JAMA (1992)

COOK COUNTY JAIL in Chicago, Ill, has reintroduced chest x-ray screening of inmates to control the spread of tuberculosis (TB), and this may signal a trend. In any case, health care authorities at the Chicago correctional facility are recommending that other large jails and prisons, especially those whose populations come primarily from urban areas, return to chest x-ray screening to stop the current resurgence of TB (<i>JAMA</i>. 1992;268:174-175 and 1992;268:855-856; and<i>JAMA</i>. 1989;262:3249-3253). Since 1985, there have been 11 known TB outbreaks in prisons in eight states. In one of these outbreaks, 13 inmates and one correctional officer died of multidrug-resistant TB. These epidemics are occurring even where inmates are being screened on admission with purified protein derivative (PPD) tuberculin skin tests, as recommended by current Centers for Disease Control and Prevention (CDC, Atlanta, Ga) guidelines, says Michael Puisis, DO, acting medical director of Cermak Health Services, Chicago, a department
Resident work hours and working environment in otolaryngology. Analysis of daily activity and resident perception
Authors: C. L. Strunk
Journal: JAMA (1991)

<h3>Objective.</h3> —To analyze the working environment and work hours of a cohort of otolaryngology—head and neck surgery residents. <h3>Design.</h3> —Environmental analysis questionnaire and a log of daily activities. <h3>Setting.</h3> —Residents were on a clinical rotation system. <h3>Participants.</h3> —Fifty-nine residents from six programs, including three public and three private institutions, from geographically diverse regions of the country were involved in the study. Residents were equally distributed from their second year through their fifth year of postgraduate work. All eligible residents participated in and completed the study. <h3>Intervention.</h3> —The environmental analysis survey was designed to elicit resident perception of different aspects of their working environment. The daily activity log required the resident to report on activities for each half-hour period for 7 consecutive days. <h3>Results.</h3> —Residents were on call an average of 52.8 hours (2.2 days) and worked 79.4 hours per week. Seventy-five percent believed that the level of faculty supervision and the degree of resident responsibility was about right. Two major inefficiencies were the time involved in completion of paperwork and the lack of nonmedical support services. Thirty-one percent of the residents responded that fatigue resulted in substandard patient care 10% of the time. Forty-seven percent responded that their educational experience was substandard 25% of the time secondary to fatigue. Two thirds responded that the demands of residency training had a negative impact on their family and personal life. <h3>Conclusions.</h3> —Seventy percent of the otolaryngology—head and neck surgery residents surveyed at six institutions believe that an 80-hour workweek, including being on call every third night with no more than 24 hours of continuous work without sleep, approximates a reasonable, maximum work schedule. Residents working the longest hours expressed concern about rendering substandard care and developing negative attitudes toward patients. Noneducational inefficiencies were identified and solutions were proposed. Demands of residency training, even within guidelines established as reasonable, can have detrimental effects on residents' educational activities and personal life. (<i>JAMA</i>. 1991;266:1371-1374)
<i>The Trial of</i>WILLIAM FREEMAM,<i>for the murder of</i>JOHN G. VAN NEST,<i>including the Evidence and the Arguments of Counsel, with the Decision of the Supreme Court granting a new triai—And of the post-mortem examination of the body by</i>Amariah Brigham, M. D.,<i>and others. Reported by</i>Benjamin F. Hall,<i>Counsellor at Law. Auburn, Derby, Miller &amp; Co., Publisheŕs,</i>1848
Journal: American Journal of Psychiatry (1848)