tbuckley/cabot-search huggingface dataset:
AB0198 In Vitro Protective Effects of Soluble Klotho (SKL) Protein on Endothelial Cells in Systemic Sclerosis (SSC)
Authors: C. Mazzotta, E. Romano, S. Bellando-Randone, J. Blagojevic, S. Guiducci, M. Matucci-Cerinic
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Systemic Sclerosis (SSc) is an autoimmune connective tissue disease characterized by impairs angiogenesis, alterations of microcirculation, senescence and apoptosis of endothelial cells (ECs). A recent study demonstrated that soluble Klotho (sKl) protein interacts with the <i>vascular endothelial growth factor receptor 2</i> (VEGFR-2) and with <i>transient receptor potential canonical-1</i> (TRPC-1) by forming a complex on the surface of endothelial cells. This heterotrimeric complex is internalized in response to <i>vascular endothelial growth factor</i> (VEGF) stimulation, thus regulating VEGFR-2/TRPC-1–mediated Ca<sup>2+</sup> influx, to maintain endothelial biological homeostasis. <h3>Objectives</h3> The aim of this study was to evaluate, if soluble Klotho might act as protective humoral factor on SSc Microvascular Endothelial Cells (MVECs) by inhibiting cellular senescence and inducing angiogenesis. <h3>Methods</h3> Wound healing capacity was performed in healthy and SSc-MVECs under standard conditions and after sKl stimulation. Angiogenesis was evaluated by <i>in vitro</i> capillary morphogenesis on Matrigel in healthy and SSc-MVECs at basal condition, upon challenge with sKl, SSc and healthy sera, and sKl in combination with SSc and healthy sera. Western blot was performed in order to evaluate TRPC-1 and VEGFR-2 expression level in SSc and healthy MVECs at basal condition, after stimulation with sKl, SSc sera (n=5), healthy sera (n=5), and with sKl in combination with SSc and healthy sera before and after wound injury. <h3>Results</h3> Wound healing capacity significantly increased in healthy and SSc-MVECs after sKl challenge in respect to basal condition. Angiogenesis was significantly higher in SSc-MVECs upon challenge with sKl compared to both basal SSc and healthy MVEC. Moreover, angiogenesis was significantly increased in healthy MVECs challenged with SSc sera in combination with sKl respect to MVECs with SSc sera alone. TRPC-1 and VEGFR-2 expression level significantly increased under injury in both healthy and SSc-MVECs cultured with sKl respect to basal condition. <h3>Conclusions</h3> Our findings suggest that, under vascular injury conditions, sKl increases the wound healing ability and induces blood vessels formation in SSc-MVECs. <h3>Disclosure of Interest</h3> None declared
In defense of adolescents
Authors: D. Offer
Journal: JAMA (1987)

ADOLESCENTS have always perplexed the adult world. By definition, a teenager is someone between childhood and adulthood. But exactly where in this continuum an individual teenager is at any one point has always been something of a mystery. Lawmakers have had difficulty in deciding at what age the privileges of adult membership in society should be extended to an individual, and confusion and inconsistencies abound. For example, in virtually every jurisdiction in the United States, a 14-year-old adolescent cannot legally vote, buy alcohol, or obtain a driver's license. Yet, if that same 14-year-old adolescent were to commit a murder, he or she could, in many states, be tried as an adult—suggesting that the adolescent has the maturity and decision-making capacity consistent with full adult responsibility for criminal behavior. <h3>Adolescent Turmoil</h3> The very notion of an "adolescent" as someone different from a child who is, however, not yet an adult in
American Journal of Medicine, New York
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
LONDON LETTER.
Authors: None G. O. M.
Journal: JAMA (1884)

London, July, 1884. Dr. Morell Mackenzie, of throat celebrity, has published a pamphlet on the subject of hay fever. The information is exhaustive. Hay fever, it seems, like influenza and cholera, did not occur in Europe in ancient times. Bostock, in 1819, first described it; Elliotson did so in 1831, and after him Phoebus, of Giessen. Helmholtz gave his views in 1869, and he was followed by many others. Dr. Morell Mackenzie considers the pollen of certain grasses to be the exciting cause. Dr. Mackenzie differs from the great Helmholtz in the importance which he assigns to quinine. He recommends with the utmost confidence, valerinate of zinc in combination with assafetida in pills of one grain of valerinate of zinc and two grains of compound assafcetida pill, doubling the dose at the end of ten days or a fortnight. He also alludes to tincture of benzoin in hay asthma, and
SOME SIALOGRAMS
Authors: L. N. Pyrah, P. R. Allison
Journal: BMJ (1931)

be consulted by those interested.In this place it may be stated that our conclusions are that the fall in blood pressure is of no practical significance.EveIn in the cases showing the maximum drop the general condition has not given rise to any anxiety.In many cases we have noted that the pressure is quickly restored spontaneously or after the administration of the ether is begun.It is quickly readjusted by the hypodermic injection of 1/2 c.cm. of a solution of ephedrine hydrochloride (50 mg. per c.cm.), and this we utilized commonly during our early experience, although, since recognizing that the condition is clinically unimportant, we are now usinig drugs less and less.Our findings in these respects are paralleled by those of other workers (for example Dandy).2. Depression of Respiration.-Slowingand reduction in the amplitude 6f respiration are common, and this effect at first gave us some concern.We have, however, seen no harm arise from it.Where severe, it is at once readjusted by administering carbon dioxide.For this purpose we find it advisable that a cylinder of oxygen containing 5 per cent.CO2 should always be at hand in the theatre.A minor disadvantage of avertin is the headache of which a considerable proportion of patients complain on wakinlg from the anaesthetic.It is readily controlled by pyrami(lon 5 grains (repeated after four hours if necessary, although one dose usually suffices).CONCLUSIONS 1. Emp!oyed in a dosage which does not exceed 0.1 gram per kilo of body weight, avertin is a safe drug.In this dosage it may suffice for minor operative work, but a supplementary inhalation anaesthesia is usually required.2. Its advantages are: (a) ease, comfort, and certainty of induction; (b) reduction of post-operative discomfort and sickness; (c) reduction of post-operative pulmonary complications.3. In this series of 1,000 unselected cases there have been no deleterious effects, either immediate or remote.4. There have been five deaths in the series, and in no instance could the fatal issue be attributed to the avertin.
Missing Funding Information in Funding/Support
Authors: Lindsay Nelson, Abpp-Cn Harvey, S Levin, Michael Mccrea, Sureyya Dikmen
Journal: JAMA Neurology (2020)

Fadi S. Hanna Al-Shaikh, BS; Ranjan Duara, MD; Julia E. Crook, PhD; Elizabeth R. Lesser, MS; Jolien Schaeverbeke, PhD; Kelly M. Hinkle, MS; Owen A. Ross, PhD; Nilufer Ertekin-Taner, MD, PhD; Otto Pedraza, PhD; Dennis W. Dickson, MD; Neill R. Graff-Radford, MBBCh, FRCP; Melissa E. Murray, PhD
Eczema and emotional and behavioural problems in childhood
Journal: British Journal of Dermatology (2020)

Eczema, emotional and behavioural problems are commonly present in childhood.It is not fully clear if eczema affects emotional and behavioural problems or that emotional and behavioural problems affect eczema in children.In this Dutch population-based study of 5,265 children, we previously identified five eczema 'phenotypes' or categories, based on their age of onset (at what age the eczema first started) and course of eczema between birth and the age of 10 years.We defined the five phenotypes as 'never eczema' (never had eczema), 'early transient eczema' (onset before age 2 years, gradually decreasing afterwards), 'mid-transient eczema' (onset around age 2 years, gradually decreasing afterwards), 'late transient eczema' (onset around age 5 years, gradually decreasing afterwards) and 'persistent eczema' (present from age 0-10 years).Additionally, we measured emotional problems (anxious, withdrawn-depressed and somatic symptoms such as constipation, dizziness, headaches) and behavioural problems (attention problems and aggressive behaviour symptoms) repeatedly from age 1Á5 to 10 years by questionnaires.Children with any of the identified eczema phenotypes had slightly more somatic symptoms (e.g.dizziness, headaches) and attention problems at school age, compared to those with the 'never eczema' phenotype.Children with 'early transient eczema' also had slightly more aggressive behaviour symptoms.It seems that the direction is from eczema in early life leading to emotional and behavioural problems in later life, rather than the other way round.In this relatively healthy and young study population, eczema very modestly affects emotional and behavioural problems, and not vice versa.Future research could examine these relationships in a clinical paediatric population, taking into account the severity of eczema, and determine the effects of optimum early eczema management on mental health disorders later in life.
LETTER FROM BOSTON.
Authors: None N.
Journal: JAMA (1888)

(FROM OUR OWN CORRESPONDENT.) Acute Lobar Pneumonia in Children— Pelvic Hœmatocele; Operation by Laparotomy; Suture of Cyst to Abdominal Wall and Drainage—Laparotomy for Volvolus—Removal of a large part of the Frontal Bone for Compound Fracture. At the meeting of the Suffolk District Medical Society, on Oct. 27, Dr. C. W. Townsend read an extensive and interesting paper on "Acute Lobar Pneumonia in Children." He said that we should make a distinction between<i>lobar</i>and<i>lobular or broncho-pneumonia</i>, although this is not generally done, it being customary to find both forms classed together in the returns as pneumonia. Lobar pneumonia is an acute specific disease, whereas lobular or broncho-pneumonia is a secondary affection and is almost always secondary to a bronchitis affecting the smaller bronchi. When a pneumonia is spoken of in young children, the lobular pneumonia is the form that is generally understood to be in consideration. This, however, should
Abstract 3322: Chronic Vascular Responses To Sirolimus-eluting Stent Compared With Bare-metal Stent In Diabetic Patients: Evaluated By Optical Coherence Tomography.
Authors: Takashi Kubo, Toshio Imanishi, Hiroki Matsumoto, Manabu Kashiwagi, Hiroto Tsujioka, Keishi Okochi, Hideyuki Ikejima, Yu Arita, Akio Kuroi, Satoshi Ueno, Hideaki Kataiwa, Takashi Tanimoto, Takashi Yamano, Hironori Kitabata, Shigeho Takarada, Atsushi Tanaka, Nobuo Nakamura, Masato Mizukoshi, Takashi Akasaka
Journal: Circulation (2007)

OBJECTIVE: An optical coherence tomography (OCT) study was performed to compre the vascular response to sirolimus-eluting stent (SES) with bare-metal stent (BMS) in patients with diabetic mellitus (DM). BACKGROUND: Despite advances in the medical treatment and revascularization procedures, coronary artery disease remains a leading cause of morbidity and mortality in patients with DM. Few retrospective subgroup analyses of pivotal clinical trials have suggested that SES may be effective for reduction of restenosis in diabetic patients. OCT is a new intravascular imaging method with a high resolution of approximately 10 micrometer and allows us to evaluate instent neointimal hyperplasia (NIH) in vivo. METHODS and RESULTS: Serial OCT analyses were performed in 60 lesions (SES in DM patients=19; SES in non-DM patients=14; BMS in DM patients=10; BMS in non-DM patients=17) at 9-month follow-up. A total of 6920 stent struts were visualized by OCT and NIH thickness inside each strut and incidence of exposed stnet struts were evaluated in cross-sectional image. The NIH thickness was significantly different among 4 groups (97 +/− 100 vs. 43 +/− 61 vs. 425 +/− 206 vs. 209 +/− 138 micrometer, respectively). The NIH thickness of SES in DM was significantly thicker than that of SES in non-DM (p&lt;0.001), although it was significantly thinner than that of BMS in DM (p&lt;0.001) or BMS in non-DM (p&lt;0.001). All struts of BMS were covered by neointima, but 14% of struts of SES were exposed. The incidence of exposed struts and exposed struts with inadequate apposition in DES were significantly lower in DM compared with those in non-DM (5% vs. 34%, p&lt;0.0001; 2% vs. 5%, p &lt;0.001, respectively). Moreover, the frequency of DES with partially exposed strut was significantly lower in DM than non-DM (32% vs. 71%, p&lt;0.027). CONCLUSION: The present OCT study revealed that DES inhibited the NIH effectively with low incidence of exposed stent strut in DM patients at 9-month after implantation.
The chemotherapy of gestational trophoblastic disease: principles of clinical management
Authors: D. P. Goldstein
Journal: JAMA (1972)

During the five years from July 1, 1965, through June 30, 1970, a total of 247 patients with molar pregnancy and gestational trophoblastic disease were treated at the New England Trophoblastic Disease Center, Boston. Of this number, 160 were treated, for uncomplicated molar pregnancy and 87 for trophoblastic disease. A new therapeutic classification based on histology, duration of disease, initial gonadotropin level prior to commencement of therapy, extent and nature of metastases, and outcome is proposed to guide the clinician in diagnosis and management.
Eighth Annual Meeting of the Association of Cytogenetic Technologists
Journal: JNCI Journal of the National Cancer Institute (1983)

Journal Article Eighth Annual Meeting of the Association of Cytogenetic Technologists Get access JNCI: Journal of the National Cancer Institute, Volume 70, Issue 2, February 1983, Page 388, https://doi.org/10.1093/jnci/70.2.388-a Published: 01 February 1983
Cereblon Expression Is Required for the Anti-Myeloma Activity of Lenalidomide and Pomalidomide
Authors: Yuan Xiao Zhu, Esteban Braggio, Chang-Xin Shi, Jessica Schmidt, Laura Bruins, Steven R. Schuster, Rafael Fonseca, P. Leif Bergsagel, Chad C. Bjorklund, Robert Z. Orlowski, A. Keith Stewart
Journal: Blood (2011)
Direct serum bilirubin and the sulfobromophthalein test in occult liver disease
Authors: S. R. Gambino
Journal: JAMA (1967)

When a sensitive method for measuring direct serum bilirubin (DB) was used, a third of the patients with liver or biliary tract disease had elevated DB levels, but normal levels of total serum bilirubin (TB). The correlation of DB and sulfobromophthalein (BSP) retention was studied because DB and BSP are cleared through the same hepatic pathway. Our findings support the clinical and chemical validity of DB measurements as an index of occult liver disease.
Ventilatory Lung Function and Chronic Chest Symptoms among the Inhabitants of Urban Areas with Various Levels of Acid Aerosols: Prospective Study in Cracow
Authors: Wieslaw Jedrychowski, Michal Krzyzanowski
Journal: Environmental Health Perspectives (1989)

The analysis carried out earlier in Cracow showed that the high level of SO2 and particulate matter (PM) alone cannot be responsible for an excess of chronic chest symptoms and faster lung function deterioration in the population at large. To check the hypothesis that acid aerosols present in the urban air may cause substantial damage of the lungs, data from a 13-year follow-up survey of chronic chest diseases in Cracow (1968-1981) have been reanalyzed. In the plan of the analysis, three areas of the city with various levels of sulfate and sulfur transformation ratio (STR) in the urban air have been defined. In each of the defined areas, the prevalence of chronic chest symptoms, as well as lung function decline, have been studied. In total, the lung function study group consisted of 1414 persons (584 males and 830 females). Those men who lived in the area with the higher sulfate and STR had lower FEV1 levels by about 151 mL than did the residents of the other areas, and this was equivalent to the effect of smoking. In females, the pattern was generally the same. In men, the FEV1 decline rate (mL/year) over the 13-year period was significantly faster by about 11 mL/year in the areas with higher and intermediate STR, which was again equivalent to the effect of smoking. It was found that the level of SO2 and PM in the urban air correlated with the symptom prevalence in women; however, it had no clear impact on lung function deterioration.
Abstract 1804: Is CPR Quality Improving? A Retrospective Study Of Out-of-hospital Cardiac Arrest
Authors: Theresa M Olasveengen, Lars Wik, Jo Kramer-Johansen, Kjetil Sunde, Morten Pytte, Petter Andreas Steen
Journal: Circulation (2007)

Aim of the study: To evaluate quality of cardiopulmonary resuscitation (CPR) performed by a physician-manned ambulance, and assess whether it changed with time influenced by developing scientific evidence and guideline changes. Materials and methods: Retrospective, observational study of all cardiac arrest patients (except trauma) older than 18 years treated between May 2003 and December 2006 by the physician-manned ambulance in Oslo. CPR quality was assessed from continuous electronic recordings from the defibrillators (LIFEPAK 12, Physio-Control or a modified Heartstart 4000, Philips Medical Systems). Ventilations were assessed from changes in transthoracic impedance, chest compressions from transthoracic impedance for LIFEPAK 12 and from an accelerometer for Heartstart 4000 (nine patients). Values are given as mean ± SD and differences analysed with ANOVA and unpaired Student’s t-test with Bonferroni correction. Results: Forty-eight of 169 consecutive cases were excluded from CPR quality analysis, 47 due to missing defibrillator data and one due to short arrest time (&lt;1 min). Hands-off intervals (fraction of time without spontaneous circulation where no chest compressions are given) were reduced from 0.18±0.11 in 2003 to 0.10±0.06 in 2006 (p=0.03). Compression and ventilation rates were significantly reduced from 122±12 and 16±3 per minute respectively in 2003 to 111±10 and 12±3 in 2006 (p&lt;0.0001 and p=0.001). In 2003–4 10% were discharged alive vs. 16 % in 2005–6 (p=0.3, Chi square test). Conclusion: High quality CPR is achievable out-of-hospital, and the improvement with time could reflect developing scientific evidence focusing on reducing hands-off intervals and hyperventilation. Quality of CPR from May 2003 to 2006.
Parental alcohol use, problem drinking, and children's injuries
Authors: P E Bijur, M Kurzon, M D Overpeck, P C Scheidt
Journal: JAMA (1992)

Millions of US children are exposed to parents who are problem drinkers, yet there is little evidence about the effect of parental alcohol consumption on children's health. The aim of this study was to assess the association between children's injuries and parental drinking.Survey of a nationally representative sample of the US population by household interview.12,360 children and parents from single-family households, with data from the Alcohol and Child Health supplements to the 1988 National Health Interview Survey.Serious injuries--injuries resulting in hospitalization, surgical treatment, missed school, one half day or more in bed.Children of mothers categorized as problem drinkers had 2.1 times the risk of serious injury as children of mothers who were nondrinkers (95% CI, 1.3 to 3.5). Other measures of mothers' alcohol consumption (ie, average, maximum, and self-rated consumption) were unrelated to child injuries, as were all measures of fathers' drinking. Children of women who were problem drinkers married to men rated as moderate or heavy drinkers had a relative risk of serious injury of 2.7 (95% CI, 0.8 to 8.6) compared with children of nondrinkers.Children of women who are problem drinkers have an elevated injury risk; children with two parents who are problem drinkers are at higher risk. Further research is needed on potential mechanisms and interventions. Primary prevention might be enhanced if physicians elicited information about parental drinking, helped secure appropriate treatment, and participated in public health efforts to reduce the deleterious effects of alcohol.
Therapeutics
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal