tbuckley/cabot-search huggingface dataset:
Prior esophageal variceal bleeding does not adversely affect survival after orthotopic liver transplantation
Authors: K Ho
Journal: Hepatology (1993)

Prior variceal bleeding may adversely affect the prognosis of orthotopic liver transplantation. We studied this question by evaluating all 175 adult patients undergoing orthotopic liver transplantation at our institution to determine risk factors associated with mortality after transplantation. Seventy patients demonstrated prior variceal bleeding, and of those, 32 had a course of sclerotherapy. Thirteen also had portal systemic shunts. Compared with the 105 transplant patients who had no prior bleeding, patients who bled were more likely to have parenchymal liver disease (74% vs. 50%), equally likely to have cholestatic liver disease (19%), and less likely to have malignancy (6% vs. 19%) or fulminant liver failure (1% vs. 12%). Bleeding patients also were more likely to be Child-Pugh class C (46% vs. 35%). By the common closing date of December 31, 1990, 26 patients (37%) with prior bleeding and 48 patients (46%) without bleeding died after transplantation. From survival curves, patients with prior bleeding had improved survival rates at 1 yr (65% vs. 54%), at 3 yr (60% vs. 47%) and at 5 yr (55% vs. 43%), although the differences were not statistically significant. With a proportional hazards model to adjust for confounding effects, the relative risk of mortality among patients with prior bleeding was 0.60 (95% confidence interval, 0.27 to 1.30). Sclerotherapy or portal systemic shunts did not alter survival. Important adverse risk factors for mortality included older age at transplantation, black race, malignant disease and more advanced Child-Pugh class. This study suggests that prior esophageal variceal bleeding did not adversely affect the mortality of patients undergoing orthotopic liver transplantation. (HEPATOLOGY 1993;18:66–72).
The Second Yearbook of Research and Statistical Methodology: Books and Reviews
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Intestinal Intubation
Authors: Meyer O. Cantor
Journal: JAMA (1968)

<h3>To the Editor:—</h3> For many years, I have admired the section inThe Journallabelled LETTERS. I consider this portion very important since it permits the reader to air his views briefly and to present interesting observations. In this latter category, is the letter by Drs. Herschman and Phillips (<b>204</b>:634, 1968). Unfortunately, the authors of the letter stated, "Intestinal intubation is frequently employed in the management of small-bowel obstruction, a procedure from which complications have not been reported." Many references in the literature report complications of all types as a result of intestinal intubation. Specifically, knot formation is relatively common, regardless of the type of tube used. It has been reported during the use of gastroduodenal tubes of all types as well as during the use of all types of long intestinal decompression tubes. The mechanism of knot formation consists of the insertion of too much tubing into the
Book Review Thérapeutique Médicale. III. Foie Glandes Endocrines et Nutrition . By Maurice Loeper, with the collaboration of Dr. Andre Lemaire. Masson &amp; Co., Libraires de L'Academie de Medicine, 120 Boulevard Saint-Germain, Paris VI, 1931. Price 50 fr.
Journal: New England Journal of Medicine (1932)
Corrigendum
Journal: BMJ (1944)

BRITISHthe subcutaneous implantation, under local anaesthesia, of 6 tablets of 100 mg.testosterone, the effect lasting six to twelve months.This treatment, however, will not increase the size of the testes and may even diminish them by pituitary inhibition.Should, therefore, the endocrine disorder be due to a primary pituitary deficiency, the testosterone treatment should be followed by, or combined with, gonadotrophic therapy.- INCOME TAXSale of Property: Tax on Civilian Earnings M. G. recently sold a house, making £300 profit on the sale.Is this liable to income tax?
Croonian Lectures on Mind, Brain, and Spinal Cord, in Certain Morbid Conditions
Authors: C. B. Radcliffe
Journal: BMJ (1873)

LECTURE II.IN the last lecture, I was venturesome enough to attack the material- istic view of mind which is at present so much in vogue, and to main- tain that mind had its foundation, not in matter merely, nor yet in spirit merely, but in something, common to both, which might be mat- ter at one time and spirit at another, so that, in reality, matter might be regarded as convertible into spirit, and spirit into matter.I attempted, I fear, more than I could hope to accomplish in any case -more than could be accomplished in the short space of an hour, cer- tainly.In my present lecture I am far less ambitious, my object being simply to deal cursorily with two practical subjects, which, though not wholly disconnected, have no necessary connexion with each other.What I now propose to do, indeed, is simply to say as much as I can in the time,-first, upon inzcilient insanity,,-and, secondly, upon a disorder, half-nervous, half-mental, to which I propose to give to give the name of neuiriasis-a disorder underlying hysteria, hypochondriasis, and certain other affections -akin to them. CONCERNING INCIPIENT INSANITY.Very loose notions are abroad respecting the symptoms of insanity.Too often, if not overlooked altogether, all symptoms are practically disregarded except the one which alone is recognised by the law of the land-namely, cdelusionz.Practically, also, delusion is regarded, not as many-sided, nzot as having often to do with certain very definite and very different morbid mental conditions other than intellectual, but simply as some undefined, unintelligible derangement of the reason.But this is a view which cannot be defended, and which must be set aside before it is possible to arrive at any clear notions respecting the symptoms of incipient insanity.If a visit be paid to a lunatic asylum, with a view, not to group the inmates in accordance with this or that classification of cases of insanityno easy task, by the way, for the groups interblend in every direction- but simply to gain such a knowledge of the symptoms of actual insanity as may aid in the detection of the symptoms of incipient insanity, the most prominent of these symptoms are, not delusion only, but self-con- ceit, misanthropy, distrust, uncontrollable imptulsiveness, melancholy, a biassed and prejudiced reason, a disordered fancy, delirious excitement,
Results of the MARS study on the management of antiangiogenics’ renovascular safety in colorectal cancer.
Authors: Isabelle Ray-Coquard, Nicolas Janus, Jean-Philippe Spano, Jean Christophe Thery, Francois Goldwasser, Olivier Mir, Philippe Beuzeboc, Catherine Daniel, Jean Francois Morere, Jean-Baptiste Rey, Christelle Jouannaud, Stephane Oudard, Florian Scotte, Michel Azizi, Richard Dorent, Gilbert Deray, Vincent Launay-Vacher
Journal: Journal of Clinical Oncology (2014)

466 Background: MARS is a prospective multicentric study conducted to assess the renovascular tolerance of anti-VEGF drugs (AVD) in the clinical setting in France, in a number of different tumor types. Methods: Patients (pts) from 8 centers were included when they were 1) naive of any AVD and 2) about to start treatment with an AVD, from 2009 to 2012, with a follow-up (f/u) of 1 year. Data collected included: gender, age, serum creatinine (SCr), HTN, hematuria (Hu) and dipstick Pu, at baseline and at each visit during f/u. This subgroup analysis presents the results for colorectal cancer (CRC) pts receiving bevacizumab (BVZ). Results: 1,124 pts were included. 200 had CRC and all but 5 received BVZ. Median age: 63.2 years. Visceral, bone, and cerebral metastasis frequencies were 91.3, 10.8, and 0.5%, respectively. All pts presented metastasis. At inclusion, HTN prevalence was 26.2%. Baseline renal assessment retrieved: Pu 30.6%, Hu 10.1%, mean aMDRD 91.1 ml/min/1.73m 2 . The incidence of de novo Pu and HTN during f/u was 78.2 and 16.1% (Table). 75.6% of pts with Pu at inclusion improved or remained stable. Among pts with de novo Pu, 60.8% afterward improved/normalized. No grade 4 Pu has been reported (at inclusion or during f/u). Renal function decreased with a mean aMDRD of 90.3 at the end of f/u. 5.9% had grade 2 SCr increase (no grade 3-4). No thrombotic micro-angiopathy (TMA) was reported. Conclusions: These results on the renovascular safety of BVZ in CC patients showed that 1) TMA is rare, 2) Pu develops in 78.2% of the pts (no grade 4), 3) 16.1% developed HTN. Furthermore, in case of a renovascular effect, investigators followed the recommendations from the French Society of Nephrology (Halimi JM. Nephrol Ther 2008) and no treatment withdrawal for unmanageable renovascular toxicity occurred. [Table: see text]
Report on Analgesic-Associated Kidney Disease
Journal: JNCI Journal of the National Cancer Institute (1984)

Journal Article Report on Analgesic-Associated Kidney Disease Get access JNCI: Journal of the National Cancer Institute, Volume 73, Issue 1, July 1984, Page 301, https://doi.org/10.1093/jnci/73.1.301-d Published: 01 July 1984
Vitamin D, Another Frontier
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Archives of Physical Medicine, Chicago
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Action and Uses in Medicine of Digitalis and Its Allies.
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cortisone
Authors: Dwight J. Ingle
Journal: JAMA (1971)

This is an autobiographical account of formative years, education, isolation of thyroxin, and research on the steroids of the adrenal cortex. It is the story of a man who picked only noble goals in biochemistry and set aside all distractions until he achieved his objectives. An early incident was prophetic. In a New York City hospital an administrator sent a box of cereal to the young biochemist and directed him to analyze it. Edward C. Kendall threw the accompanying letter and the cereal into the wastebasket and continued his research on the thyroid gland. He found himself out of place in the laboratory of a pharmaceutical house and again in the laboratory of a hospital that was not interested in research. He then moved to the Mayo Clinic which supported his research until he reached the age of retirement. At Mayo's he isolated thyroxin on Christmas Day, 1914. By 1930
Phosphorus Poisoning
Authors: William B. Jackson
Journal: JAMA (1976)

<h3>To the Editor.—</h3> The ar rial on phosphorus poisoning (235: 1343, 1976) are most timely but, unfortunately, not entirely accurate. As ly mon and Pickering indicate, elemental phosphorus has long been employed as a been employed form, it is used as a paste and smeared on some edible product. However, both EPA labeling However, both lationstional Pestlations and N sociationctice statements caution about using such a material on recognizable food, such as bread or crackers, and placing the bait form where children can find it. the bait form where nately, and practice are not always the same. However, this form of the rodenticide is used relatively little these days, in part because of the atively li ardoblem, and it is available only to professional workers. mwonder whether the cases cited are of recent occurrence. Another compound, zinc phosphide,<i>is</i>one of the frequently used acute (single de, is one of
Book Review You and Heredity, Including an Original Study of the Inheritance of Musical Talent . By Amram Scheinfeld, assisted in the genetic sections by Morton D. Schweitzer, Ph.D. 8°, cloth, 421 pp., with 4 color plates and 75 drawings, maps and diagrams. New York: Frederick A. Stokes Co., 1939. $3.00.
Journal: New England Journal of Medicine (1940)
The usefulness of serum X-linked inhibitor of apoptosis protein (XIAP) for predicting recurrence of renal cell carcinoma.
Authors: Fumiya Hongo, Daisuke Toiyama, Takashi Ueda, Yasunori Kimura, Terukazu Nakamura, Kazuya Mikami, Natsuki Takaha, Tsuneharu Miki
Journal: Journal of Clinical Oncology (2012)

e15055 Background: The X-linked Inhibitor of Apoptosis protein (XIAP) is associated with cell survival by blocking caspase-mediated apoptosis. We have reported the expression and prognostic value of XIAP in human prostate cancer using prostate tissue microarrays (Clin Cancer Res 2007). The expression and prognostic significance of XIAP in renal cell cancer (RCC) has been rarely studied. To our knowledge, no report on the serum XIAP levels from RCC patients has been published. In this study, we examined serum XIAP levels of RCC patients and normal individuals and evaluated its utility as biomarker. Methods: Peripheral blood samples were obtained from 99 patients (68 men and 31 women, median age; 60.7 years [36-85]) with RCC before surgery. All the patients underwent radical or partial nephrectomy. Blood samples were also collected from 52 healthy controls. The histological grade was as follows: grade 1; n= 5, grade 2; n=72, grade 3; n= 22. The serum XIAP levels were measured by a sandwich enzyme-linked immunosorbent assay. Cut off value was calculated by ROC analysis. Results: The serum XIAP levels in patients with RCC were higher than those of normal control individuals (328.3 pg/ml vs 156.2 pg/ml, p&lt;0.001). At a median follow up of 33 months (1-105M), tumor with low serum XIAP showed significantly longer progression free survival (PFS) than those with high serum XIAP in grade 1-2 group (p&lt;0.001). Conclusions: Serum XIAP level is associated with recurrence and prognosis. These results suggest that it may be used as a novel prognosticator and a potential target for renal cell cancer diagnosis and therapy.
Disappointing biotech
Authors: Roberta Joppi, Vittorio Bertele, Silvio Garattini
Journal: BMJ (2005)

Biotechnology offered the hope of cheaper and better drugs.Analysis of biotech products licensed in Europe shows the reality is somewhat differentThe advent of DNA recombinant techniques and other biotechnologies has raised expectations for more selective drugs.The techniques promise "magic bullets" that are better tolerated because they are more similar to endogenous products and cheaper to make thanks to potential large scale production.Thus biotech products offer a good model for assessing the level of therapeutic innovation of drugs.We assessed the biotech medicines approved by the European Medicine Evaluation Agency from its inception in 1995 to 2003, when the European pharmaceutical law was revised. 1 The agency approved 87 biotech products, corresponding to 65 active ingredients, during this period.Four were approved for diagnostic purposes.How innovative were the 61 licensed with more therapeutic indications?Further details of the method are on bmj.comAngioplasty balloon device used to unblock and widen arteries
No sewage in the streets.
Journal: BMJ (1980)

animals, the extrapolation of which to man is of doubtful validity.Nevertheless, dietary restriction has never been proved to be actually disadvantageous and, since other effective treatment was lacking, -a pattern of reasonable, not unduly restrictive dietary advice became standard.Today we have different remedies.Most duodenal ulcers can be induced to heal by histamine H2 blockade; and, where appropriate, recurrence may be prevented by long-term drug treatment.While the ascetic puritan may shake his head at the opportunity this gives for patients with duodenal ulcers to live and eat injudiciously without risk (rather as some deplore promiscuity free of the risk of pregnancy with modern contraception), the fact is that life is better if a normal diet can be eaten.Dietary regimens will not survive much longer, even for the enthusiasts.1 Paffenbarger RS jun, Wing AL, Hyde RT.Chronic disease in former college students.XIII.
Oral Contraceptives
Authors: Robert W. Kistner
Journal: JAMA (1966)

This is a concise review of the chemical, biological, and clinical facts pertaining to the oral contraceptive agents. The author is editor of<i>Pharmacology in Medicine</i>and lecturer in pharmacology at Northwestern University Medical School and the University of Illinois, and he is eminently qualified to present and analyze these data. After reviewing briefly the structural differences of the various compounds, he describes their biologic properties with particular emphasis on pituitary, gonadotropic, and endometrial effects. A chapter on clinical effectiveness is replete with comparative tables of the agents available both in the United States and abroad. Menstrual cycle phenomena, frequently confusing to both physician and patient, are clearly explained. Of particular importance is the discussion of associated endocrine effects of the oral contraceptives on specific complaints associated with ovulatory cycles, eg, dysmenorrhea, premenstrual tension, breast engorgement, lactation, body weight, and edema. The relationship of these agents to chloasma, acne, and
CLASS PUBLICATIONS.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Response to Letters Regarding Article, “Comparative Effectiveness of Exercise Electrocardiography With or Without Myocardial Perfusion Single Photon Emission Computed Tomography in Women With Suspected Coronary Artery Disease: Results From the What Is the Optimal Method for Ischemia Evaluation in Women (WOMEN) Trial”
Authors: Leslee J. Shaw, Emir Veledar, Nanette K. Wenger, Jennifer H. Mieres, Robert H. Hendel, William E. Boden, Martha Gulati, Rory Hachamovitch, James A. Arrighi, C. Noel Bairey Merz, Raymond J. Gibbons, Gary V. Heller
Journal: Circulation (2012)