tbuckley/cabot-search huggingface dataset:
Cross-allergenicity of penicillins and cephalosporins
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Health and behavioral consequences of binge drinking in college. A national survey of students at 140 campuses
Authors: H. Wechsler
Journal: JAMA (1994)

<h3>Objective.</h3> —To examine the extent of binge drinking by college students and the ensuing health and behavioral problems that binge drinkers create for themselves and others on their campus. <h3>Design.</h3> —Self-administered survey mailed to a national representative sample of US 4-year college students. <h3>Setting.</h3> —One hundred forty US 4-year colleges in 1993. <h3>Participants.</h3> —A total of 17592 college students. <h3>Main Outcome Measures.</h3> —Self-reports of drinking behavior, alcohol-related health problems, and other problems. <h3>Results.</h3> —Almost half (44%) of college students responding to the survey were binge drinkers, including almost one fifth (19%) of the students who were frequent binge drinkers. Frequent binge drinkers are more likely to experience serious health and other consequences of their drinking behavior than other students. Almost half (47%) of the frequent binge drinkers experienced five or more different drinking-related problems, including injuries and engaging in unplanned sex, since the beginning of the school year. Most binge drinkers do not consider themselves to be problem drinkers and have not sought treatment for an alcohol problem. Binge drinkers create problems for classmates who are not binge drinkers. Students who are not binge drinkers at schools with higher binge rates were more likely than students at schools with lower binge rates to experience problems such as being pushed, hit, or assaulted or experiencing an unwanted sexual advance. <h3>Conclusions.</h3> —Binge drinking is widespread on college campuses. Programs aimed at reducing this problem should focus on frequent binge drinkers, refer them to treatment or educational programs, and emphasize the harm they cause for students who are not binge drinkers. (<i>JAMA</i>. 1994;272:1672-1677)
CORRECTION
Authors: Gavin Wright, J-E Holty, M Gould
Journal: Thorax (2007)

systematic sampling, but is avoided in trials with patients prospectively randomised and analysed on an intention-to-treat basis.We emphasise that we did not perform any stagebased subanalyses, but compared the whole CMLND population with the systematic sampling group.The exclusions after randomisation clearly should not have occurred, but were adequately reported.In all, 25 patients had small-cell cancer or a non-malignant pathology, 48 had incomplete primary resection, 5 turned out to have metastatic deposits from other sites and 15 were excluded because of upstaging to IIIB or IV only.The exclusions were well matched, with 52 occurring in the CMLND group and 41 in the systematic sampling group.We therefore believe this had little effect on the overall analysis.It should also be mentioned that in one of the trials, only patients with cT1N0 adenocarcinoma of (2 cm diameter were randomised.Mechanistically, the authors hypothesised that this is the group least likely to benefit from CMLND; however, their inclusion in the pooled analysis still resulted in a clear benefit in favour of CMLND.In fact, the pooled hazard ratio of 0.78 is superior to that of adjuvant chemotherapy meta-analyses 4 that have created such enthusiasm in lung cancer circles of late.Therefore, we are concerned that as a result of this editorial, groups treating lung cancer may not demand from their surgeons that which they are demanding from their medical oncologists-an evidence-based improvement in survival with an adjuvant intervention.We also await the results of the ACOSOG Z30 trial, 5 which will address this question for patients in clinical stage I.This will also allow a pooled analysis of 1959 patients, which should be able to put this question to rest after 50 years of controversy.Until then, the level I evidence is that CMLND should be performed as part of the surgical treatment of patients with stage I-IIIA non-small-cell lung cancer.
From the Tobacco Control Committee
Journal: Journal of Thoracic Oncology (2020)

Out-of-sample forecasts are used to evaluate the predictive adequacy of a previously published national model of the relationship between smoking behavior and real per capita health care expenditure using state level aggregate data.This new analysis demonstrated that the model forecasts out-of-sample well.In summary, reductions in smoking produce substantial savings in real per capita healthcare expenditure in short to medium term.A 5% relative drop in smoking prevalence (about a 0.87% reduction in absolute prevalence) combined with a 5% drop in consumption per remaining smoker (about 16 packs/year) would be followed by a $31.5 billion reduction in healthcare expenditure (in 2014 dollars).
BOVINE VS. HUMAN TUBERCULOSIS.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effects of Estrogen-Only Treatment in Postmenopausal Women
Authors: Katherine L Brubaker
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PATIENT-REPORTED OUTCOME MEASURES IN CLINICAL STUDIES FOR MYELODYSPLASTIC SYNDROMES AND ACUTE MYELOID LEUKEMIA: A LITERATURE REVIEW AND LANDSCAPE ANALYSIS
Authors: H. Chevrou-Séverac, J. Lambert, I. Savre, P. Koochaki, L. Gaugler, I. Stojkov, U. Siebert, R. Stauder
Journal: HemaSphere (2019)
CNS Effects or Mitral Commissurotomy
Authors: Charlyne T. Herbert
Journal: JAMA (1964)

<h3>To the Editor:—</h3> Dr. Jarvik does no more than make general statements about the necessity of a control group in an experiment like ours. He cites no objective data to support the assertion that "effects of practice are manifested almost universally...." David Wechsler, author of the Wechsler Adult Intelligence Scale (WAIS), stated to me personally in 1960 that one reason he did not make two forms of the WAIS was that the items had been shown by experiment<i>not</i>to be affected by practice in a hospital population. In the new revision of the Stanford-Binet, it is pointed out that insignificant practice effects were found when the same form was used for retesting; therefore, the new revision came out in only one form. Further, the word "practice" implies that some learning is taking place. Impairment of learning is only one of the signs of malfunction which one looks for in
Obituary Listing
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A pooled analysis of the effect of age on adjuvant cisplatin-based chemotherapy for completely resected non-small cell lung cancer (NSCLC)
Authors: M. Fruh, H. Tribodet, J. Pignon, T. Winton, T. Le Chevalier, G. V. Scagliotti, J. Y. Douillard, L. Seymour, S. G. Spiro, F. A. Shepherd
Journal: Journal of Clinical Oncology (2007)

7553 Background: Adjuvant cisplatin-based chemotherapy (CT) has been shown to increase survival in NSCLC, but uncertainty exists concerning its efficacy and toxicity in elderly patients (≥ 70). Methods: We performed a pooled analysis using individual patient data from 4,584 patients in the LACE database with resected stage IA-III NSCLC enrolled in 5 randomized trials, comparing postoperative CT to no CT (ALPI, ANITA, BLT, IALT and JBR10). Patient and treatment characteristics, CT toxicity and delivery, overall survival, disease-free survival (DFS) and cause-specific mortality were compared among 3 age groups: 3,269 (71%) young (&lt;65), 901 (20%) mid-category (65–69) and 414 (9%) elderly (≥70). The analysis was performed on an intent-to-treat basis. Cox models stratified by trials and adjusted for age, associated drug, planned radiotherapy, total dose of cisplatin (&lt;300, 300, &gt;300), gender, stage, performance status, type of surgery and histology were used with a test for trend to study the effect of CT on survival according to age. Results: Baseline characteristics differed among the age groups, but this was due mainly to the different trial populations and designs. No difference in severe toxicity rate was observed among the age groups. Elderly patients received significantly smaller total doses of cisplatin than the other patients (Chi 2 -test: p&lt;0.0001) and also the cisplatin doses received were more often lower than the planned one (Kruskal-Wallis test: p&lt;0.0001). The Hazard ratio (HR) of death for the young patients was 0.82 (95% CI 0.73–0.92), 0.86 (95% CI 0.70–1.07) for the mid category and 1.01 (95% CI 0.78–1.32) for elderly patients (test for trend: p=0.17). The HR for DFS was 0.79 (95% CI 0.71–0.87) for the young, 0.76 (95% 0.62–0.93) for the mid category and 0.94 (95% CI 0.73–1.22) for the elderly patients (test for trend: p=0.35). More elderly patients died from non- lung cancer related causes (10% young, 16% mid category and 20% elderly; p&lt;0.0001). Conclusions: The survival benefit from cisplatin-based adjuvant therapy for NSCLC patients was not significantly different according to age, but this may be due to lack of power. Supported by unrestricted grants from PHRC and LNCC No significant financial relationships to disclose.
Physicians and domestic violence. Ethical considerations. Council on Ethical and Judicial Affairs, American Medical Association
Journal: JAMA (1992)

DOMESTIC violence, spouse abuse, and battering all refer to the victimization of a person with whom the abuser has or has had an intimate/romantic relationship.<sup>1,2</sup>These three terms are used interchangeably throughout this article. Domestic violence may take the form of physical, sexual, and psychological abuse, is generally repeated, and often escalates within relationships.<sup>3-7</sup> Most evidence indicates that domestic violence is predominantly perpetrated by men against women.<sup>8-11</sup>Some evidence suggests that women are as likely to use violence against male partners as men are against female partners.<sup>12</sup>However, these research findings have been criticized on various counts as misleading.<sup>13(p312),14(pp181-183),15</sup>In particular, it is clear that the impact on the health of female victims of domestic violence is generally much more severe than the impact on the health of male victims.<sup>3,14,16</sup>Battering is also known to occur in gay and lesbian relationships, but there has
Nutrition History
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Is proliferative index (Ki 67) useful to stratify patients (pts) with G2 gastro-entero-pancreatic neuroendocrine tumors (GEP-NETs)? Clinicopathologic correlation.
Authors: Juan O Connor, Martin Angel, Veronica Pesce, Guillermo Ariel Mendez, Claudia Bestani, Fabiana Marmissolle, Nora Giacomi, Susana Belli, Enzo Domenichini, Matias Chacon, Victor Zamora, Ana Maria Cabanne, Patricia Parma, Enrique Luis Roca
Journal: Journal of Clinical Oncology (2015)

e15188 Background: Grade 2 (G2) Neuroendocrine tumors (NETs), of the digestive tract is a heterogeneous group of tumors. Several treatment options including chemotherapy and target therapy are available, but there is a lack of prospective trials assessing the role of pronostic factors in this population. Aim(s): to analyze prognostic factors and clinical characteristics in a population of patients with G2 GEP-NETs. To determine the role of ki 67 in the stratification of G2 population. Methods: Study population was obtained from our prospective database (Argentum Group). Survival was estimated using the Kaplan-Meier method and compared between Ki-67 quartiles using the log-rank test. Value of Ki-67 to discriminate mortality was assesed with a ROC curve analysis Results: 144 pts were evaluated. Mean age 54.9, 46.7% male. 102 (70.8%) with metastatic disease, mainly hepatic in 97 pts. (67.4%). 67.9 % underwent surgery. 34% received chemotherapy, and 10.9% target therapy. Median Ki-67value was 6 (IQR 4-10), ROC curve = 0.62 (95% CI 0.53 a 0.72 p = 0.021. cut-off: 6.5 (sensitivity 62.2%, specificity 57.7%). Median survival was 97, 67, 51 and 27 months according stratification by quartile (p.001), 45 events (31.7%). Conclusions: Our results suggest that in the heterogenous G2 GEP-NETs there are significant differences in survival. This study was underpowered to detect differences between Ki-67 quartiles, we detected that chemotherapy was mostly used in the higher quartiles
Die entzündliche Grundlage der typischen Geschwürsbildung im Magen und Duodenum.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A clinical appraisal of the treatment of chronic duodenal ulcer by vagotomy and gastric drainage operation
Journal: Gut (1961)

Methods and techniques SUMMARY Biopsies of the mucosa of the small intestine of 22 patients were subjected to light and electron microscopic studies.The patients were grouped into 'controls', coeliac disease, and idiopathic steatorrhoea, and in the last two groups the clinical condition and therapeutic progress was recorded.Electron microscopic studies were directed mainly towards the microvilli of the surface epithelium.It was found that the latter were decreased in height in coeliac disease and idiopathic steatorrhoea and showed greater irregularity in shape and spacing.A good correlation existed between the light microscope appearances of villous atrophy and decrease in surface cell height and the electron microscope findings of microvillous abnormalities.Our thanks are due to the many physicians who kindly referred their patients to us for investigation, to Dr. R. A. B. Drury and Mr. J. E. Mayhew for the histology, and Mrs.
NEW INSTRUMENTS.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MNGI-36. BRAIN INVASION IN MENINGIOMAS PREVIOUSLY CLASSIFIED AS WHO GRADE I HAS LIMITED IMPACT ON OUTCOME
Authors: Annamaria Biczok, Bogdana Suchorska, Rupert Egensperger, Jörg-Christian Tonn, Christian Schichor
Journal: Neuro-Oncology (2018)

The revision of the WHO classification in 2016 introduced brain invasion as a per se sufficient condition for meningiomas to be classified as grade II. We analyzed whether meningiomas previously graded as WHO grade I according to the 2007 version differ in prognosis solely according to the feature of brain invasion. From 1/2009 - 03/2016 all consecutive patients with surgery of a meningioma WHO grade I (2007 grading system) were included. Reference point of the study was date of surgery. Brain invasion was re-evaluated in all cases by a neuropathologist being blinded for the clinical course. Date of last follow up was 11/2017. Study endpoint was the date of tumor progression. Prognostic factors were obtained from multivariate proportional hazards models. 949 adult patients were included. Median follow-up was 43 months (range: 3–78 months). Gross total resection (GTR) was achieved in 719 (75.8%) patients, adjuvant radiotherapy was applied in 91 (9.9%) patients. Brain invasion was diagnosed by histology in 24 (2.5%) patients. Patients with/without brain invasion did not differ in terms of age and extent of resection. Patients with histologically proven brain invasion received more often adjuvant radiotherapy (p=0.02). 88 patients experienced tumor recurrence, overall survival was not reached in the majority of patients. The overall median PFS for patients with (without) brain invasion was 22 (23) months (p=0.48). In Subtotal resection and history of another malignancy were associated with shorter PFS in univariate and multivariate models (p<0.001), but neither brain invasion nor radiotherapy. Among meningiomas classified as grade I according to the WHO 2007 grading system, histological proven brain invasion is rare and was not associated with worse prognosis in contrast to extent of resection and history of another malignancy. However, whether postoperative radiotherapy might have been beneficial for these patients has to be analysed prospectively.