tbuckley/cabot-search huggingface dataset:
Coronary Care
Authors: Robert J. Henning
Journal: JAMA (1981)

Each year, a million Americans experience acute myocardial infarctions. Despite improvements in the treatment of malignant arrhythmias, which complicate myocardial infarction, coronary heart disease persists as a leading cause of death in the United States. Recognizing the importance of this medical problem, Drs Karliner and Gregoratos and coauthors have compiled a detailed treatise of contemporary acute coronary care. The textbook discusses the pathogenesis, diagnosis, and treatment of uncomplicated and complicated acute myocardial infarction, the organization and operation of the coronary care unit, monitoring and diagnostic techniques, principles of equipment maintenance, and problems with electrical hazards. The treatment of congestive heart failure and cardiogenic shock and the use of the intra-aortic balloon pump and vasodilator drug therapy are discussed in separate chapters in an attempt to be comprehensive, although these topics overlap and should be combined. Detailed discussions are presented on unstable and variant angina; pharmacology, including analgesics, antiarrhythmic agents, and
Radiographie néphro-cholécystique.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A BILL TO PREVENT FRAUDS IN "PATENT MEDICINES."
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Technical Considerations in the Treatment of Tetralogy of Fallot
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nederlands Tijdschr Geneeskunde, Amsterdam
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Multiple Meningiomas
Authors: A Leondi, V Valotassiou, J Koutsikos, S Tsiouris, E Mainta, C Zerva
Journal: Clinical Nuclear Medicine (2005)

A 57-year-old woman with hyperthyroid ophthalmopathy underwent somatostatin receptor scintigraphy with In-111 pentetreotide. She also reported migraine-type headaches over the previous 3 months, without any other obvious neurologic symptoms and signs. The study revealed an increased uptake of the radiopharmaceutical in both periorbital areas and the right lobe of the thyroid gland. Multiple foci of marked tracer uptake were also detected in the right half of the head. A brain MRI scan subsequently revealed multiple lesions consistent with meningiomas on the surface of the right cerebral hemisphere.
Spence Galbraith
Authors: C. Bartlett, S. Galbraith
Journal: BMJ (2009)

Cryopreserved rat hepatocytes entrapped within an alginate matrix commercially available as Liverbeads™, were evaluated for their relevance as a screening tool for gene induction <i>in vitro</i>, using qRT-PCR. They were treated with the reference compounds beta-naphthoflavone (BNF), phenobarbital (PB), pregnenolone 16α-carbonitrile (PCN) and clofibric acid (CLO) and analyzed for mRNA levels of Cyp1a1, Cyp2b1, Cyp3a1, Cyp4a1, Ugt1a6 and Ugt2b1. In addition, for PB and PCN, the results were compared with those obtained in rat liver in vivo. For each inducer the gene induction profiles obtained with the Liverbeads™ <i>in vitro</i> model were time- and dose- dependent. The <i>in vitro</i> gene expression profiles confirmed the corresponding known CYP and UGT induction by each reference compound. Specifically, the most strongly induced genes were Cyp1a1 by BNF, Cyp2b1 by PB, Cyp3a1 and Ugt2b1 by PCN and Cyp4a1 and Cyp2b1 by CLO. Other genes investigated were also induced by the reference compounds but the expression levels were lower and increases were seen only after prolonged treatment. Specifically, Ugt1a6 and Cyp2b1 were increased by BNF, Cyp1a1, Cyp3a1 and Ugt2b1 by PB and Cyp3a1 and Ugt2b1 by CLO. All these results correlated well with published <i>in vitro</i> data and our <i>in vivo</i> data. In conclusion, our results suggest that Liverbeads™ is a relevant and useful <i>in vitro</i> screening tool for determining gene induction profiles of new molecules. In addition, as Liverbeads™ from different species are available, this tool offers the possibility to conduct interspecies comparisons.
Exposures from Indoor Spraying of Chlorpyrifos Pose Greater Health Risks to Children than Currently Estimated
Authors: Devra Lee Davis, A. Karim Ahmed
Journal: Environmental Health Perspectives (1998)

Recent findings of indoor exposure studies of chlorpyrifos indicate that young children are at higher risks to the semivolatile pesticide than had been previously estimated [Gurunathan et al., Environ Health Perspect 106:9-16 (1998)]. The study showed that after a single broadcast use of the pesticide by certified applicators in apartment rooms, chlorpyrifos continued to accumulate on children's toys and hard surfaces 2 weeks after spraying. Based on the findings of this and other research studies, the estimated chlorpyrifos exposure levels from indoor spraying for children are approximately 21-119 times above the current recommended reference dose of 3 microg/kg/day from all sources. A joint agreement reached between the U.S. Environmental Protection Agency and the registrants of chlorpyrifos-based products will phase out a number of indoor uses of the pesticide, including broadcast spraying and direct uses on pets. While crack and crevice treatment of insects (such as cockroaches and termites) by chlorpyrifos will still continue, it appears prudent to explore other insect control options, including the use of baits, traps, and insect sterilants and growth regulators. To ensure global protection, adequate dissemination of appropriate safety and regulatory information to developing regions of the world is critical, where importation and local production of chlorpyrifos-based products for indoor uses may be significant.
CORRECTION
Authors: R Kiesslich, A Hoffman, M Goetz, S Biesterfeld, M Vieth, P Galle, M Neurath
Journal: Gut (2006)

In conclusion, endomicroscopy allows localisation and measurement of the amount of collagenous bands in the mucosal layer.Thus endomicroscopy offers the possibility of targeted biopsies, which is a new approach in collagenous colitis where randomised biopsies, preferably in the right colon, are recommended.The distribution of the collagenous bands is patchy and segmental in the colon.Confocal endomicroscopy helps to differentiate between affected and normal sites.This initial experience was proven in four additional patients.In all patients, collagenous colitis was precisely predicted and the amount of collagenous bands was measured.However, this new diagnostic possibility and its sensitivity and specificity must now be evaluated in prospective studies.
Kipp
Authors: H. J. Van Peenen
Journal: Annals of Internal Medicine (1994)

On Being a Doctor15 June 1994KippH. J. Van Peenen, MDH. J. Van Peenen, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-120-12-199406150-00011 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail How clever Professor Bellmaster had been! Or was it just my bad luck? Here I was, a second-year student at the Laguna Honda Home in San Francisco, meeting my final exam in Physical Diagnosis. He was an old man named Kipp and he couldn't talk. Or wouldn't.How could Bellmaster have known that I had learned so little from him, that I was hopelessly inept in the arts of observation, palpation, percussion, and auscultation? I thought I had successfully hidden from him, for I always sat in the exact center of the lecture hall, crouched behind the broad, concealing shoulders ... Author, Article, and Disclosure InformationAuthors: H. J. Van Peenen, MDCorresponding Author: H. J. Van Peenen, MD, 3910 Courtney Lane Southeast, Salem, OR 97302. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 June 1994Volume 120, Issue 12Page: 1041-1042KeywordsHeartKneesMusclesReflexesRespirationSpineSpleenSweatTendonsThorax ePublished: 15 August 2000 Issue Published: 15 June 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Progestogens and cancer.
Journal: BMJ (1971)

caemia is a potent stimulus to ACTH secretion in normal persons, and this was also true of the patients with Addison's disease.Further, dexamethasone, which will normally suppress secretion of ACTH by a feedback mechanism, retained this ability in patients with Addison's disease.Measurement of plasma levels of C terminal ACTH in five patients with Addison's disease showed consistently higher values than of N terminal ACTH levels.It is known that differences between biological and immunological ACTH activity can occur, and these would seem more likely to be observed when an immunoassay method is used to detect the inactive C terminal portion of the ACTH molecule.Unfortunately an antibody against the N terminal portion is more difficult to raise, but interpretation of its values is more likely to be valid in clinical situations where such knowledge is important.
A higher prevalence of onychomycosis in psoriatics compared with non-psoriatics: a multicentre study
Authors: A.K. GUPTA, C.W. LYNDE, H.C. JAIN, R.G. SIBBALD, B.E. ELEWSKI, C.R. DANIEL, G.N. WATTEEL, R.C. SUMMERBELL
Journal: British Journal of Dermatology (1997)
Cholestasis. Proceedings of the International Congress on cholestasis and related disorders, Florence, Italy, 23?26 March 1994 Edited by P. Gentilini, I. M. Arias, N. McIntyre, and J. Rodes, 382 pp. Amsterdam: Elsevier Science, 1994. $200
Authors: M SOSTEK
Journal: Hepatology (1995)

The finding that a lens under oxidative stress accumulated free and protein-bound cysteine (protein-S–S-cysteine) in the fiber cells prompted us to examine if there is an alternative source for cysteine pools besides the active cysteine transport system in the lens, namely, the transsulfuration pathway of homocysteine–cystathionine–cysteine, which utilises methionine through transmethylation. We examined the presence of the gene for cystathionine-beta-synthase (CBS), the rate limiting enzyme that converts homocysteine to cystathionine in the transsulfuration pathway, in human lens epithelial (HLE) B3 cells using PCR with primers designed based on the sequence of human liver CBS (Forward 5′-CCA CAC TGC CCC GGC AAA AT-3′; Reverse 5′-CTG GCA ATG CCC GTG ATG GT-3′). The purified DNA fragment (586 bp) from PCR analysis was sequenced and confirmed the homology with CBS gene from other human tissues. The CBS protein band (67 kDa) was present in the HLE cells, which reacted positively with the human liver anti-CBS antibody. The enzyme protein was detected in the pig and human lenses with the highest intensity in the epithelial layer, lower but equal quantities of CBS was present in the cortical and nuclear regions. Human nuclear CBS increased while epithelial CBS decreased with aging. Oxidative stress transiently upregulated the gene expression of CBS both in HLE cells (0·1 mmH2O2) and in pig lens cultured in TC 199 medium (0·5 mmH2O2). The catalytic activity for CBS, which was assayed by measuring the production of C14-cystathionine from C14-serine in the presence of homocysteine, S-adenosyl-methionine and pyridoxal phosphate, was detectable in the HLE cells and transiently activated with H2O2. Free cystathionine accumulated when HLE B3 cells were treated with propargylglycine (PGG), an inhibitor of cystathionase, the downstream enzyme that converts cystathionine to cysteine. More cystathionine accumulation occurred when the cells were simultaneously exposed to PGG and 0·1 mmH2O2. We have shown that oxidative stress of H2O2 could increase the flux of this transsulfuration pathway by committing more homocysteine to cysteine and glutathione production as H2O2 (0·1 mm) inhibited the remethylation enzyme of methionine synthase while concurrently activating the CBS enzyme. This is the first evidence that a transsulfuration pathway is present in the lens, and that it can be upregulated under oxidative stress to provide additional redox potential for the cells.
From the Alcohol, Drug Abuse, and Mental Health Administration
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
NIH panel report of 'no flaws' in FIAU trial at variance with FDA report, new probe planned
Authors: C. Marwick
Journal: JAMA (1994)

THE TRAGIC deaths of five patients in a National Institutes of Health (NIH) study of the experimental hepatitis drug fialuridine or fluoroidoarauracil (FIAU) were, given the circumstances, "unavoidable" and due to a wholly new type of unexpected and delayed liver toxicity. There were no noteworthy flaws in the conduct of the study. This is the conclusion of an exhaustive review of the situation conducted by a subcommittee of the NIH Director's Advisory Committee chaired by David R. Challoner, MD, vice president for health affairs, University of Florida College of Medicine, Gainesville, and David M. Kipnis, MD, distinguished university professor of medicine, Washington University School of Medicine, St Louis, Mo. The inquiry was conducted at the request of NIH Director Harold Varmus, MD, and the report presented at a committee meeting on June 2. This report, the second to follow the deaths, could be viewed as at variance with an earlier
Running
Authors: J. D. Cantwell
Journal: JAMA (1978)

RUNNING is popular these days. CBS refused to preempt a special on marathon running to make way for President Carter's speech on the Panama Canal; the same week, a book on running climbed to the top of the list of nonfiction best sellers. In Atlanta, 6,000 people ran 10 km down Peachtree Street in 31<sup>°</sup>C weather (last July 4), participating with Olympians Lasse Viren and Frank Shorter. It is estimated that 25 million Americans, approximately 10% of the population, run on a regular basis. I started running years ago as a freshman medical student at Northwestern University in Chicago. I would find relief from the pressures of anatomy classes by running on the outdoor track adjacent to the school. The track was the scene of my greatest athletic triumph, the place where I broke the world record for the onemile run. It happened this way. To keep my
Correction
Journal: Circulation (2015)

In the article by Burke et al, "Current Science on Consumer Use of Mobile Health for Cardiovascular Disease Prevention: A Scientific Statement From the American Heart Association," which published ahead of print August 13, 2015, and appeared in the September 22, 2015, issue of the journal (Circulation. 2015;132:1157-1213. DOI: 10.1161/CIR.0000000000000232), several corrections were needed.1. On page 1203, in the first column, last paragraph, the second sentence read, "Because medication may be a component of the treatment, we also searched for meditation adherence." It has been changed to read, "Because medication may be a component of the treatment, we also searched for medication adherence." 2. On page 1204, in the second column, third complete paragraph, the second sentence read, "As with any other product that claims to improve health, groups will want to answers to certain questions…." It has been changed to read, "As with any other product that claims to improve health, groups will want answers to certain questions…."3. On page 1204, in the second column, last paragraph, the fourth sentence read, "However, the responsibility for generating evidence should not fall solely only on the product developers." It has been changed to read, "However, the responsibility for generating evidence should not fall solely on the product developers." These corrections have been made to the print version and to the current online version of the article, which is available at http://circ.ahajournals.org/content/132/12/1157.full
Hospital-acquired serum hepatitis. Report of an outbreak
Authors: R. A. Garibaldi
Journal: JAMA (1972)

Eleven persons who had previously been patients in a community hospital in Cook County, Illinois, had onset of serum hepatitis in May, June, and July 1969. Three months before developing hepatitis, all 11 had been hospitalized on the same ward and cared for by a nurse who was late in the incubation period of serum hepatitis. The 11 hepatitis patients had no unique exposures to hepatotoxic drugs, blood transfusions, contaminated foods or water, or other hepatitis cases. However, they had been given more inoculations by the infected nurse than did a comparison group of patients selected from the same ward. Although no obvious breaks in aseptic technique were found, it seems likely that the virus was spread from nurse to patients by either parenteral or oral contact. The exact route of transmission, however, was not established.
Fatal rectus sheath hematoma
Authors: B. S. Ducatman
Journal: JAMA (1983)

Rectus sheath hematoma is an uncommon, often misdiagnosed, and usually self-limited condition. In a recent review of autopsy cases at the Mayo Clinic, Rochester, Minn, we found two patients in whom hemorrhages into the rectus sheaths were considered the immediate cause of death and one in whom the hemorrhage was considered a contributing cause of death. Rectus sheath hematoma should be included in the differential diagnosis of an abdominal mass of sudden onset, especially in patients who have been given anticoagulants. The condition may be fatal if the volume of the hemorrhage is large and if treatment is delayed. (<i>JAMA</i>1983;249:924-925)