tbuckley/cabot-search huggingface dataset:
Cantharides intoxication.
Authors: R D Rosin
Journal: BMJ (1967)

Preparations containing cantharides, commonly known as " Spanish fly," have been used since the time of Hippocrates for conditions such as dropsy and amenorrhoea, and for the aphrodisiac properties that it is wrongly thought to possess.Cantharides is the active component contained in the ovaries, soft tissues, and blood of the blister beetle Cantharis vesicatoria.It contains not less than 0.6% of cantharidin (3: 6-epoxy-1 :2- dimethylcyclohexane-1:2-dicarboxylic anhydride), which is the active principle.The fatal dose of cantharidin is described as being less than 60 mg.(Nickolls and Teare, 1954).
Incorrect Phrasing
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Neurology
Authors: R. J. Joynt
Journal: JAMA (1994)

Advances in molecular genetics marked the major advances last year in neurology; however, major developments also occurred in other areas, particularly in new types of therapy. Late last year, two excellent reviews summarizing advances in the genetics of neurologic diseases were published.<sup>1,2</sup>The unstable trinucleotide repeat continues to turn up as the genetic defect in several inherited neurologic disorders, including Huntington's disease, spinobulbar muscular atrophy, myotonic dystrophy, and spinocerebellar ataxia type 1.<sup>1,2</sup>The number of repeats is related to severity or latency in the different disorders. Late-onset familial Alzheimer's disease (FAD) has been associated with a defect on chromosome 19.<sup>3</sup>The defect is linked with apolipoprotein E, which transports cholesterol into the brain. Apolipoprotein E binds with amyloid and is found with amyloid and with the neurofibrillary tangles in the brain of those with Alzheimer's disease. The<i>E4</i>allele of apolipoprotein E is found in 45% of
The Use of 5-Fluorodeoxyuridine (FUDR) as a Surgical Adjuvant in Carcinoma of the Stomach and Colorectum— Veterans Administration Adjuvant Cancer Chemotherapy Cooperative Group
Journal: JAMA (1963)

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Error in Table and Figure
Authors: Alexander Egeberg, Jacob Thyssen
Journal: JAMA Neurology (2016)

Pashtun Shahim, MD; Yelverton Tegner, MD, PhD; David H. Wilson, PhD; Jeffrey Randall, PhD; Tobias Skillbäck, MD; David Pazooki, MD, PhD; Birgitta Kallberg, BSc; Kaj Blennow, MD, PhD; Henrik Zetterberg, MD, PhD
Table of Contents
Authors: Junko Yamauchi, Haruhiko Osawa, Tomomi Takasuka, Masaaki Ochi, Akiko Murakami, Wataru Nishida, Hiroshi Onuma, Yasunori Takata, Yasuharu Tabara, Tetsuro Miki, Jun Ohashi, Hideichi Makino, Hiroshi Nakatani, Hiroshi Hirose, Yukihiro Yamamoto, Ikuo Saito, Hiroshi Itoh, Giorgio Viviani, Alessandra Puddu, Gianni Sacchi, Anna Garuti, Daniela Storace, Arianna Durante, Fiammetta Monacelli, Patrizio Odetti, Hideki Nojima, Hiroshi Watanabe, Kiminori Yamane, Yoshihiro Kitahara, Kiyokazu Sekikawa, Hideya Yamamoto, Akihito Yokoyama, Tsutomu Inamizu, Toshimasa Asahara, Nobuoki Kohno, Akira Sekikawa, Hirotsugu Ueshima, Kim Sutton-Tyrrell, Takashi Kadowaki, Aiman El-Saed, Tomonori Okamura, Tomoko Takamiya, Yoshiki Ueno, Rhobert Evans, Yasuyuki Nakamura, Daniel Edmundowicz, Atsunori Kashiwagi, Hiroshi Maegawa, Lewis Kuller, Ramin Alemzadeh, Jessica Kichler, Ghufran Babar, Mariaelena Calhoun, Vanessa De Mello, Marjukka Kolehmainen, Ursula Schwab, Ursula Mager, David Laaksonen, Leena Pulkkinen, Leo Niskanen, Helena Gylling, Mustafa Atalay, Rainer Rauramaa, Matti Uusitupa, Arlette Perry, Xuewen Wang, Ronald Goldberg, Robert Ross, Loreto Jackson, Altan Onat, Günay Can, Gülay Hergenç, Hirokazu Tsukahara, Naoko Ohta, Shuko Tokuriki, Koji Nishijima, Fumikazu Kotsuji, Hisako Kawakami, Norihito Ohta, Kyouichi Sekine, Hironori Nagasaka, Mitsufumi Mayumi, Jarek Mäestu, Jaak Jürimäe, Ivo Valter, Toivo Jürimäe, R Scott, Robert Rogers, Meghan Ruebel, Pamela Hinton, Anthony Lucas, Alain Grynberg, Bernard Lacour, Françoise Goirand
Journal: Metabolism (2008)
The effect of change in PSA velocity on overall survival (OS) in men with biochemically recurrent prostate cancer (BRPC) treated with nonhormonal agents: Combined analysis of four phase 2 trials.
Authors: Daniel L. Suzman, Marianna Zahurak, Michael Anthony Carducci, Mario A. Eisenberger, Emmanuel S. Antonarakis
Journal: Journal of Clinical Oncology (2014)

5050 Background: Multiple phase 2 trials in men with BRPC have assessed the impact of non-hormonal agents on PSA kinetics. We have previously demonstrated that changes in PSA kinetics are correlated with metastasis-free survival; however, it is unknown whether these changes may also correlate with overall survival (OS). Methods: We performed a combined retrospective analysis of 146 men with BRPC treated on phase 2 trials using one of four investigational drugs: lenalidomide (n=60), marimastat (n=39), ATN-224 (n=22), and imatinib (n=25). We examined factors influencing OS, including within-subject changes in PSA kinetics (PSA slope, PSA doubling time, and PSA velocity) before and 6 months after treatment initiation. Results: After median follow up of 137 months, 48 men had died. In univariate Cox regression analysis, four factors were associated with OS: prior androgen deprivation therapy (ADT), prior local radiotherapy, baseline PSA velocity, and change in PSA velocity after therapy. In a landmark multivariable model, stratified by study, which also controlled for age and Gleason score (<7 vs ≥7): prior radiotherapy, baseline PSA velocity, and increase in PSA velocity remained independent predictors of OS (Table). Median OS for men with an increase in PSA velocity on treatment was 9.4 years vs not-yet-reached for men with a decrease in PSA velocity (HR 2.2; 95% CI 1.10-4.39; P=0.03). Conclusions: This hypothesis-generating study suggests that within-subject changes in PSA velocity after initiation of non-hormonal therapy may correlate with OS in men with BRPC. If validated in prospective trials using OS as the primary endpoint, change in PSA velocity may represent a reasonable intermediate endpoint for screening new agents in these patients. Variable Multivariate HR (95% CI) P Age, y (continuous) 0.97 (0.93, 1.02) 0.26 Gleason score >7 0.95 (0.38, 2.38) 0.92 ≤7 1 Prior radiotherapy Yes 2.20 (1.03, 4.73) 0.04 No 1 Prior use of ADT Yes 0.79 (0.36, 1.73) 0.55 No 1 Baseline PSA velocity Above median 2.49 (1.33, 4.65) 0.004 Below median 1 Δ in PSA velocity Increase 2.20 (1.10, 4.39) 0.03 No increase 1
Deaths
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
DNA fingerprints come to court
Authors: B. Merz
Journal: JAMA (1988)

"COMB SEARCHES" may be on the way to replacing strip searches in criminals' nightmares, thanks to a new technique known as DNA fingerprinting. The technique, which produces a visual representation of a person's genome, enables the identification of perpetrators from as little as a single hair root, providing they have left some biologic evidence—hair, skin cells, blood, or semen—at the scene of the crime. DNA fingerprinting was developed by British geneticist Alec Jeffreys, PhD, in 1985. Jeffreys, professor of genetics at the University of Leicester, built upon a discovery, five years earlier, of certain hypervariable regions called minisatellites in unexpressed areas of DNA. The hypervariability was evidenced in the number of repetitions of certain sequences of base pairs. For example, in a given minisatellite, a certain 32-base pair segment may appear 28 times in one person's DNA, 22 times in another's, and 19 times in a third person's. It was
JAMES J. PUTNAM (1846-1918) BOSTON NEUROLOGIST
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Replicable abstinence rates in an alcoholism treatment program
Authors: O. W. Neubuerger
Journal: JAMA (1982)

Treatment outcome studies of alcoholism have historically had innumerable difficulties and controversy. Few investigators ever have reported a replication of their initial study results, let alone the crossvalidation of such initial results. This article provides results of a four-year replication study of a medical behavioral treatment approach. Comparisons of patients receiving a uniform treatment were made at yearly intervals. A few variables are identified to clarify who will or will not achieve and maintain follow-up sobriety, although it is admitted that our knowledge in this area is still rudimentary. These results affirm for the practitioner today that the alcoholic patient is treatable with a high probability of success. When the outcome of treatment is positive, the diagnosis and referral become crucial for alcoholism just as for other treatable diseases. (<i>JAMA</i>1982;248:960-963)
JAMA Reference Directories
Journal: JAMA (1989)

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The Essentials of Medical Diagnosis. A Manual for Students and Practitioners.
Authors: Patient Louis, G Moench
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clara
Authors: CARL SPIVACK
Journal: Annals of Internal Medicine (1980)

Ad Libitum1 March 1980ClaraCARL SPIVACK, M.D.CARL SPIVACK, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-92-3-432 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptClara was so elderly—she was so much an antique thing—that she could not state her age with certainty. "I am eighty. Yes eighty," she said to herself as She sat in a hall chair. "Eighty years lie behind me. Life, an immeasurable corridor of experience and chante, lies behind me. I, a creature of eighty, bent over and worn, continue along the corridor of life." The decades had not impaired Clara's perceptions or the clarity of her mind. The poorly attired, white-haired creature of eighty, seated in the corridor, whom some might think a victim of age and its impoverishment,... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: CARL SPIVACK, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1980Volume 92, Issue 3Page: 432-432KeywordsPerception ePublished: 1 December 2008 Issue Published: 1 March 1980 PDF downloadLoading ...
From the NIH
Journal: JAMA (1984)

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Erratum: A TRAF-like motif of the inducible costimulator ICOS controls development of germinal center TFH cells via the kinase TBK1
Authors: Christophe Pedros, Yaoyang Zhang, Joyce K Hu, Youn Soo Choi, Ann J Canonigo-Balancio, John R Yates, Amnon Altman, Shane Crotty, Kok-Fai Kong
Journal: Nature Immunology (2016)
Medicare and medical students
Authors: J. R. Scholten
Journal: JAMA (1966)

Of 1,500 medical students at four medical schools, 1,053 anonymously and voluntarily completed questionnaires eliciting information on their knowledge and attitudes toward the Medicare program. Their responses indicate that 80% of them have little or no knowledge regarding the details of the program. Despite this lack of information, a large majority of the students have opinions which are, in general, negative. The attitudes and opinions expressed were remarkably homogeneous in each of the four classes at each school. There were differences between the schools which may depend upon the ecology of the school, ie, socioeconomic background of students and types of careers pursued by the graduates. On the basis of data available, it would seem that a significant proportion of medical students believe that their career plans have been altered by this legislation. This ranges from a high of 24.6% in the fourth-year class of school C to a low of 3.5% of the first-year class in school B.
Tuberculosis patient care of the future
Authors: William W. Stead
Journal: JAMA (1971)

<h3>To the Editor.—</h3> Your EDITORIAL, "Care of Tuberculosis Patients: Reprise," may well involve you in a very hot issue with inadequate consideration of all sides of the problem. Physicians engaged in tuberculosis work have resisted closing of facilities and have emphasized the points made in your EDITORIAL, but the truth of the matter today is that the fiscal crisis that exists in every government unit in the country is simply forcing city councils, county supervisors, and state legislators to look to a change in ways of managing tuberculosis as a means of reducing expenditures. And, it is not entirely unreasonable, because very considerable savings can be realized without compromising quality of care, if intelligent reorganization of facilities is undertaken in advance. In former years, and persisting to the present, outpatient facilities for supervision of chemotherapy have been an appendage to inpatient facilities. Outpatient facilities have usually had no real budget
INANITION IMMUNITY
Journal: JAMA (1946)

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HAZARDOUS HOMES
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal