tbuckley/cabot-search huggingface dataset:
THE PRESENT STATUS OF HYDROPHOBIA.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Conjugation of Organic Pollutants in Aquatic Species
Authors: Margaret O. James
Journal: Environmental Health Perspectives (1987)

Aquatic organisms can take up organic pollutants from their environment and subsequently excrete the pollutant or its biotransformation products (metabolites). Phase II (conjugation) biotransformation products are almost always less toxic than the unmetabolized organic pollutant. For many organic pollutants, the extent to which conjugates are formed is extremely important in determining the rate of excretion of the pollutant. This is because most conjugates (glycosides, sulfates, amino acid conjugates, mercapturic acids) are organic anions which are readily water-soluble and are rapidly excreted by fish (and probably higher invertebrates) by a combination of glomerular filtration and tubular transport. In this paper, each major conjugation pathway is discussed with respect to what is known about its occurrence in fish and aquatic invertebrates, both from in vivo and in vitro data. Although limited data are available, this paper also considers what is known about how each conjugation reaction affects the toxicity and potential for renal and biliary excretion of organic xenobiotic substrates.
Oral Medicine
Authors: Francis P. McCarthy, Philip L. McCarthy
Journal: New England Journal of Medicine (1955)

IN the preparation of this progress report on oral diseases, primarily concerning the oral mucosa, we were impressed by the paucity of literature dealing with the mouth as an entity. Much of the literature consists of reports of clinical cases of general interest such as a reaction to a drug with oral manifestations.During the past decade the dental and dermatologic journals have furnished most of the information that one might refer to as progress in the subject of oral medicine. Many lesions involving the mucous membrane of the mouth, other than discrete lesions from local causes such as leukoplakia . . .
ESGE Newsletter
Journal: Endoscopy (2010)

Natural orifice transluminal endoscopic surgery (NOTES) is becoming increasingly attractive for the surgeon – but what about the gastroenterologist? Various surgical procedures such as hybrid NOTES cholecystectomy, single-incision laparoscopic surgery (SILS), transvaginal surgery with rigid endoscopes, and transumbilical surgery with flexible endoscopes (E-NOTES), all of them adopting the concept of scarless surgery, have recently been integrated into clinical routine medicine, at least in highly specialized centers. The term ”NOTES” has become a trademark for innovative, minimally invasive surgery. However, as gastroenterologists never perform such procedures, you may well ask why they should be interested in scarless surgical interventions such as NOTES cholecystectomies or appendectomies. The initial hype is over; is it now time for the gastrointestinal endoscopist to quietly retreat? The answer is: No, it is not!
LETTER FROM NEW YORK.
Authors: None P. B. P.
Journal: JAMA (1890)

(FROM OUR OWN CORRESPONDENT.) Annual Meeting of the Fifth District Branch of the New York State Medical Association—New York Academy of Medicine—Consolidation of Cancer Hospitals—Adirondack Park Association—New York County Medical Association—American Pediatric Society—Miscellaneous Gleanings. The annual meeting of the Fifth District Branch of the New York State Medical Association, which was held as usual in Brooklyn, was unusually well attended this year, and was very successful in every way. A pleasant feature of the gathering was a bountiful luncheon served between the morning and afternoon sessions, and which was paid for out of the accumulation of interest from the Permanent Fund of the Branch. The President for this term is Dr. Wm. McCollom, of Brooklyn, and after his introductory address interesting biographical sketches of Dr. Isaac E. Taylor and Dr. Charles S. Wood, the lamented President of the New York County Medical Association, were read by Drs. John Shrady and
A clinician's guide to the office measurement of cholesterol
Authors: J. J. Burke
Journal: JAMA (1988)

The office laboratory has the potential to be an ideal setting for cholesterol testing if accurate test results are achieved. This study describes the performance of three office chemistry analyzers (Abbott Vision, Boehringer-Mannheim Reflotron, and Kodak Ektachem DT60 Analyzer) in the measurement of cholesterol. The accuracy of these instruments was assessed by testing aliquots of 84 plasma specimens and comparing these results with values obtained in one of the National Heart, Lung, and Blood Institute's Lipid Research Clinic laboratories. To evaluate instrument precision, results from each of the three instruments were compared with the cholesterol standards recently released by the College of American Pathologists. When operated according to the manufacturers' recommended procedures, each of the three instruments demonstrated analytic capabilities that met the current accuracy and precision goals established by the National Cholesterol Education Program. Analytic issues that are pertinent to the clinician's role as both the office laboratory director and the test interpreter are reviewed. (<i>JAMA</i>1988;259:3444-3448)
Abstract LB-071: Functional NK cells generated from human iPS cells with 3D-bioreactor for immuno-oncology
Authors: Qiang Feng, Miao-yun Zhang, Shi-Jiang Lu
Journal: Cancer Research (2019)

Abstract NK cells are cytotoxic cells critical for innate immune system. Early investigation using NK cells carrying CAR specific targeting tumor antigens have shown promising antitumor activities. CAR-T therapy requires either autologous or MHC matching cells to avoid graft-verse-host disease (GVHD), whereas allogeneic NK cells showed substantial anti-tumor activity without GVHD. Therefore, the “ready-to-kill” NK population is regarded as the ideal Off-The-Shelf immune cell therapy products. The development of NK-based immunotherapy, however, has been limited by unsatisfactory sources of human NK cells. Human induced pluripotent stem cells (iPSCs) offer unlimited source for manufacturing NK cells suitable for immunotherapy. Previously NK cell derivation methods from human iPS cells used feeder cells with multiple scale-up limited processes which are not suitable for industrial scale production. In this study we described a novel 3D-bioreactor platform that can continuously generate highly pure NK cells with strong cytotoxic activity for 2 weeks. First, undifferentiated human iPS cells were cultured as 3D-spheres with mesoderm inducing conditions in bioreactor, which converted 60-70% iPS cells into hemogenic endothelial progenitor (HEP, CD31+CD144+CD34+) in a week. HEP cells were then cultured under NK cell differentiation condition for up to 35 days. Starting from day 20, NK cells were started to release from these 3D-spheres which can be harvested daily by centrifugation. These iPS-NK cells can be cryopreserved for long time. Human iPS-NK cells display a distinctively homogenous morphology. Over 95% of collected cells express CD56, NKG2D, NKp44 and NKp46 markers; Approximately 30-50% of CD56+ iPS-NK cells express KIR2DL/DS1 and KIR2DS4 receptors; CD56+ PSC-NK cells do not express TCR and CD3, and CD19, which are specific markers for T and B cells, respectively. Surprisingly, we discovered that more than 80% CD56+ iPS-NK cells also expressed CD8 as compared to ≈30% of peripheral blood CD56+ NK cells, the increase of which is associated with disease regression in AIDS patients. More importantly, when iPS-NK cells and K562 leukemia cells were mixed together, even at a ratio of 1 to 1, more than 80% of leukemia cells were killed within hours as demonstrated both by flow cytometry analysis and time-lapse record. With the establishment of permanent master iPS-CAR cell lines, our novel technology platform will provide inexhaustible cell sources for the generation of truly off-the-shelf CAR-NK cells suitable for treatment of a large numbers of patients, which can revolutionize the field of immuno-oncology. Citation Format: Qiang Feng, Miao-yun Zhang, Shi-Jiang Lu. Functional NK cells generated from human iPS cells with 3D-bioreactor for immuno-oncology [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr LB-071.
Abstract 2607: Impact Of Acute Myocardial Infarction On Perfusion In Non-infarct Related Territories. Study With Sestamibi G-spect Imaging
Authors: Jerzy Pregowski, Michal Ciszewski, Anna Teresinska, Lukasz Kalinczuk, Mariusz Kruk, Radoslaw Pracon, Adam Witkowski, Artur Debski, Witold Ruzyllo
Journal: Circulation (2007)

In the setting of acute STEM blood flow may be slower also in non infarct related arteries. This may impact perfusion beyond infarct zone. The aim of our study was to assess viability and perfusion in non-infarcted myocardium using sestamibi G-SPECT. 36 pts with anterior STEMI within 12 hours from pain onset were enrolled. All pts were hemodynamically stable (Kilip≤3) on admission, without prior myocardial infarction and underwent primary angioplasty (pPCI). Two G-SPECTs at rest were performed: SPECT 1 - sestamibi injected immediately before pPCI (scintigrams registered within 6 hrs from pPCI) and SPECT 2, performed 5– 8 days later. Perfusion of the myocardium was visually assessed and standard grading (0 – 4) for 17 segments was used, where 0 indicates no, 1 - mild, 2 and 3 moderate perfusion abnormalities and 4 - total lack of perfusion. Sum of perfusion segmental defects grades for each territory and for the whole myocardium produces respective Summary Defect Score (SDS) indices. Higher SDS indicates more severe and wider perfusion defect. Left anterior descending artery (LAD) territory consists of 7, right coronary (RCA) and left circumflex artery (LCX) territories consist of 5 segments. Separate SDS for LAD (SDS LAD), for RCA (SDS RCA) and for LCX (SDS LCX) territories were calculated for SPECT 1 and SPECT 2. Also SDS for basal RCA segments (SDS RCA basal) and for basal LCX segments (SDS LCX basal) were calculated to avoid bias related to overlapping of blood supply. Results are presented in Table . Both total SDS and SDS indices for separate vessel territories decreased while left ventricle ejection fraction increased between G-SPECT 1 and G-SPECT 2 procedures. Conclusions In pts with anterior STEMI and culprit lesion in LAD perfusion of inferior wall is significantly reduced in acute phase. This suggests that anterior STEMI may cause global myocardial ischemia even in patients without cardiogenic shock. Table
The Funnies
Authors: George N. Braman
Journal: Annals of Internal Medicine (2007)

Ad Libitum20 February 2007The FunniesGeorge N. Braman, MDGeorge N. Braman, MDFrom Bronx, New York.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-146-4-200702200-00010 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ”Everything, in my humble opinion, is a joking matter.”– Rumpole for the Prosecution, John MortimerCalled “the Funnies” (but they weren't very)—We read them every Sunday front to backAnd waited for them every week—”TerryAnd the Pirates,” Dick Tracy,” “Smilin' Jack.”Weird characters, like the “Dragon Lady”Stirred our appetite for exotic lands;Tracy's villains, sinister and shady,Kept unearthing diabolic plans.Now, living in a deeply worried ageThose youthful fantasies have fled too soon—We need not scurry to “the Funnies” pageTo see our planet as a big cartoon.Global warming, terrorism unfurled—We're living through a not-so-funny world. Author, Article, and Disclosure InformationAffiliations: From Bronx, New York.Current Author Address: George N. Braman, MD, 6142 Delafield Avenue, Bronx, NY 10471. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 20 February 2007Volume 146, Issue 4Page: 300 ePublished: 20 February 2007 Issue Published: 20 February 2007 Copyright & PermissionsCopyright © 2007 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Cellular Effects of Ionizing Radiation
Authors: John B. Little
Journal: New England Journal of Medicine (1968)

STUDIES of the biologic effects of ionizing radiation began very shortly after Roentgen's discovery of the x-ray in December, 1895. The special characteristics of this radiation, which differentiated it from chemical toxic agents, were soon appreciated. Notable among these is its ability to penetrate cells and to deposit energy within them in a random fashion, unaffected by the usual cellular barriers presented to chemical agents. It is only within the past decade, however, that considerable progress has been made in determining how radiation kills mammalian cells. Although much of this progress was made possible by the development of culture methods . . .
Good Fridays
Authors: C D Singer
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Legal interventions during pregnancy. Court-ordered medical treatments and legal penalties for potentially harmful behavior by pregnant women
Journal: JAMA (1990)

This report by the American Medical Association's Board of Trustees discusses legal and policy concerns of legal intervention when a pregnant woman's behavior (refusal of recommended treatment, abuse of alcohol or drugs, etc.) endangers her fetus. Among the topics addressed are the moral and legal responsibilities of the pregnant woman toward the fetus, and the ethical obligations of the physician in instances of treatment refusal; the adverse consequences of seeking court-ordered interventions; and alternative responses -- legal, medical, and educational -- to harmful behavior by the pregnant woman. The Board of Trustees concludes that judicial intervention rarely is appropriate when a pregnant woman makes an informed refusal of treatment. The report ends with six recommendations for formulating AMA policy on how physicians should respond when a pregnant patient's refusal of treatment or noncompliance with her physician's recommendations could affect the well-being of the fetus.
ROUTINE CIRCUMCISION
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Old Age
Authors: Edgar A. Calvelo
Journal: Annals of Internal Medicine (1998)

Ad Libitum15 October 1998Old AgeEdgar A. Calvelo, MDEdgar A. Calvelo, MDNapa, CA 94558Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-129-8-199810150-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail You are strange, sublime, caring.... Author, Article, and Disclosure InformationAffiliations: Napa, CA 94558Corresponding Author: Edgar A. Calvelo, MD, 3932 Montrose Street, Napa, CA 94558. Previousarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 October 1998Volume 129, Issue 8Page: 666-667KeywordsAnklesFatigueHoneyStrokeTemperature ePublished: 15 August 2000 Issue Published: 15 October 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
PPARγ-induced cardiolipotoxicity in mice is ameliorated by PPARα deficiency despite increases in fatty acid oxidation
Authors: Ni-Huiping Son, Shuiqing Yu, Joseph Tuinei, Kotaro Arai, Hiroko Hamai, Shunichi Homma, Gerald I. Shulman, E. Dale Abel, Ira J. Goldberg
Journal: Journal of Clinical Investigation (2010)

During the preparation of this manuscript, the units for palmitate oxidation in Figure 5A
Orthopedic Surgery
Authors: Robert Poss
Journal: JAMA (1989)

Dramatic advances have occurred recently in three areas of orthopedic surgery: total joint arthroplasty, spine surgery, and arthroscopy. The first results of modern total hip arthroplasty (THA) were reported by Charnley<sup>1</sup>in 1961. The American experience began in 1968. Although THA performed in the 1970s produced a revision rate of approximately 10% at 10 years,<sup>2,3</sup>radiological review of these patients suggested a higher rate of impending failure with time. It was generally assumed that the weak link in THA was fixation by bone cement. These observations gave impetus to the development of cementless arthroplasty as an alternative, particularly for younger, active patients. Concomitantly, improved prosthetic designs and cementing techniques have improved the results of cemented THA. Femoral component loosening in the first 5 to 10 years after surgery is now far less likely when using modern cementing techniques<sup>4-6</sup>and is seemingly well controlled in the initial experience
Letter: Squints.
Journal: BMJ (1976)

was also inoculated intracerebrally into a strain of mice known to be susceptible to acanthamoebae, but amoebae were not isolated.Dr Griffin also suggests that repeated naso- pharyngeal specimens should have been examined for acanthamoebae.In fact this also was done.Nose and throat swabs taken two days after admis- sion and two and four days later were inoculated into HeLa cell cultures, on to klebsiella-agar plates, and intracerebrally into mice, again with negative results.
Analysis of Air Pollution Effects: Uncertainties in Proceeding to Standards
Authors: Stanley V. Dawson
Journal: Environmental Health Perspectives (1983)

Uncertainties in the collection and assessment of scientific information make ambient air quality standard setting difficult. Uncertainties occur in the estimation of the medical parameters under test due to the inherent random variability encountered in sampling the parameters. The most common method of dealing with random variability is statistical significance testing. The main caution offered in regard to that analysis is to avoid calling a nonsignificant result negative, unless the circumstances are such that the smallest effect which indicates likely harm to health could have been detected with sufficiently high probability. Uncertainties also play a crucial role in evaluating the implications that even statistically significant test results have for human health. A signal-detection model, developed to explain expert performance in evaluating the results of such diagnostic tests as X-rays, is presented as an analogy for the situation facing experts who are evaluating the implications of health data that is being considered for use in setting a standard. If criteria are too strict for accepting data as evidence of harm to health, then it is argued that, as a consequence, the decision process will not have sufficient ability to discriminate against false-negative results. False-negative results are those that incorrectly conclude there is no threat when, in fact, a particular level of pollutant is actually a threat to health.
Health is a community affair. Preview of the final report of the National Commission on Community Health Services
Authors: D. W. Roberts
Journal: JAMA (1966)

Health is essentially a community affair. This premise has been basic to the activities of the National Commission on Community Health Services. The National Commission, which will bring its operations to a conclusion in August 1966, is a private, nonprofit study group established in 1962 by the National Health Council and the American Public Health Association, yet independent of both. It is financed approximately equally from private and public funds. Thirty-two commissioners, representing a cross-section from medicine, business, labor, voluntary groups, government, and other fields, under the chairmanship of Marion B. Folsom, direct its activities. This month, the final report of the Commission was released. The National Commission was formed because of concerns of those in the field of community health regarding the availability and the accessibility of community health services both today and for the future. There had been revolutions in population distribution, in medical science and technology, in