tbuckley/cabot-search huggingface dataset:
Research and innovation in global cancer control
Authors: George A O Alleyne
Journal: The Lancet Global Health (2018)

The global approach to cancer control must not hide the gross inequalities in cancer prevention and control. One of the reasons for these inequalities is the deficiency in knowledge creation in low-income and middle-income countries because it is the knowledge generated by research that will drive the innovations for cancer control. The knowledge ladder is made up of data, information, knowledge, and wisdom. I describe crucial areas of research-surveillance systems, implementation research, and research that involve the application of behavioural economics. There is no ideal taxonomy of innovations, but a simple one is offered: supply and demand or need-driven innovations. The supply-driven innovations employ technology and devices. Innovations driven by demand and need include social innovation and innovation to address an unattended need, especially in the poor. The weakness of surveillance systems and cancer registries, despite their importance for surveillance, might be a reflection of the fact that health systems on which the dissemination and implementation of innovations depend are open systems, are counterintuitive, and resist incorporation of policies or other inputs that could change them. At the Toronto Global Cancer Control Conference, March 1–3, 2018, we will examine the multisectoral approach to cancer prevention and control, with reference to the triple-helix model of innovation, which involves academia, business, and the government, and the growing interest in public–private partnerships. Suggestions will be made for enhancing visibility of the problem, strengthening and widening the epistemic community, and for framing the issue not only as a matter of welfare but as one of utility. I declare no competing interests.
Fetal heart rate response to maternal exertion
Authors: M. W. Carpenter
Journal: JAMA (1988)

Doppler monitoring of fetal heart rates during maternal exertion has suggested that fetal bradycardia occurs frequently during vigorous exercise, causing concern for fetal safety. Doppler determination of fetal heart rate during vigorous maternal effort is difficult. To avoid motion artifact, we observed fetal heart rate using two-dimensional ultrasound and determined the incidence of fetal bradycardia in 45 pregnant women (age, 29.0±3.7 years [mean ± SD]; gestational age, 25.2 ± 3.0 weeks) during 85 submaximal and 79 maximal cycle ergometer tests. Average fetal heart rate did not change during exercise. A single episode of fetal bradycardia (heart rate &lt;110 beats per minute for ≥10 s) occurred during submaximal exertion during a maternal vasovagal episode. Sixteen episodes of fetal bradycardia were noted within three minutes after cessation of exercise, 15 of which followed maximal maternal effort. We conclude that brief submaximal maternal exercise up to approximately 70% of maximal aerobic power (maternal heart rate ≤148 beats per minute) does not affect fetal heart rate. In contrast to submaximal maternal exertion, maximal exertion is commonly followed by fetal bradycardia. This may indicate inadequate fetal gas exchange. (<i>JAMA</i>1988;259:3006-3009)
Keeping up with Cancer
Journal: CA A Cancer Journal for Clinicians (1956)

weeks after the last dose, Because of the insidious and relatively asyniptomatic on set, the cure rate of ovarian cancer is not high.The five-year survival reported by Munnell and Taylor was 30.8 per cent.Hysterectomy, with bilateral salpingo oophorectomy and removal of the entire carcinomatous process, is the treatment of choice.This was attempted when feasible in the twenty-six patients of this series.and twenty-four had roentgen-ray therapy after surgery.TEM offers a slight but definite advance in the palliative treatment of advanced ovarian carcinoma.
Obituary Listing
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Neonatology: Pathophysiology and Management of the Newborn
Authors: Philip Sunshine
Journal: JAMA (1981)

<b>Intensive Care in the Newborn, III,</b>by Leo Stern, Bernard Salle, and Bent Friis-Hansen, 415 pp, with illus, $59.50, New York, Masson Publishing USA Inc, 1981. The second edition of<i>Neonatology</i>, edited by Avery, is much improved over the first edition, which itself was an excellent reference text. Several of the chapters have been completely rewritten and extensively updated, while others have had little revision. New chapters have been added and enhance the value of the book. Excellent are the chapter on obstetrical anesthesia, Dr Brazelton's chapter "Behavioral Competence in Newborn Infants," and a review by Tsang and Steichen of calcium and magnesium homeostasis in newborns. The chapter on neonatal jaundice has been completely rewritten and is the outstanding feature of the book. Dr Maisels brings us up to date on bilirubin metabolism and neonatal jaundice. Several other sections leave much to be desired and probably detract from an otherwise
On ethics and advocacy
Authors: W. E. May
Journal: JAMA (1986)

WE ARE presently witnessing an apparent divergence of the statements of traditional ethical standards and the actual practice of physicians. This circumstance is a serious threat to our own perception of the validity of our ethical ideals and to the public's perception of our professional integrity. It has recently been urged<sup>1,2</sup>1,2 that organized medicine take a firmer stand in declaring physician participation in the business aspects of medicine to be unethical. The primary stated goals of those urgings are to maintain the professionalism of medical practice and to strengthen the physician's role of patient advocacy. I believe, however, that some basic fallacies in the arguments create the likelihood of the opposite effects if such a course is pursued. The first of these fallacies involves the identification of the alternatives being compared. The implication is that either we will see physician-entrepreneurs, responding to the business exigencies of the "bottom
Paraffin in Surgery. A Critical and Clinical Study.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Obituaries
Journal: JAMA (1982)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE TOXIC EFFECTS OF FORMALDEHYDE (FORMALIN).
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
International J Fertility, Springfield, Mass
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 15899: The Effect of Cerebral Oxygenation on Cardiac Arrest Outcomes: A Multicenter Pilot Observational Study
Authors: Sam Parnia, Jie Yang, Robert T Nguyen, Anna Ahn, Loren Inigo-Santiago, Jiawen Zhu, Asad Nasir, Kim Golder, Shreyas Ravishankar, Pauline Bartlett, Jianjin Xu, David Pogson, Sarah Cooke, Christopher Walker, Ken Spearpoint, David Kitson, Teresa Melody, Mehboob Chilwan, Elinor R Schoenfeld, Paul S Richman, Barbara Mills, Nancy Wichtendahl, Jerry Nolan, Adam J Singer, Stephen Brett, Gavin D Perkins, Charles D Deakin
Journal: Circulation (2015)

Background: Cardiac arrest (CA) is associated with morbidity and mortality due to cerebral ischemia. We therefore tested the hypothesis that higher regional cerebral oxygenation (rSO2) during resuscitation is associated with improved return of spontaneous circulation (ROSC), survival and neurological outcomes at hospital discharge. We further examined the validity of rSO2 as a test to predict these outcomes. Methods: Multicenter prospective study of in-hospital CA (IHCA). Inclusion criteria: IHCA, age≥18 years, Prolonged CPR≥5 minutes. Patients were recruited consecutively during working hours between 08/2011-09/2014. Survival with a favorable neurological outcome was defined as a Cerebral Performance Category (CPC)1-2. Results: Among 504 IHCA events, 183 (36%) met inclusion criteria. Overall 62/183 (33.9%) achieved ROSC, while 13/183(7.1%) achieved CPC1-2 at discharge. Higher mean±SD rSO2 was associated with ROSC vs. no ROSC (51.8±11.2% vs. 40.9±12.3%) and CPC1-2 vs. CPC3-5 (56.1±10.0% vs. 43.8±12.8%), both P&lt;0.001). Mean rSO2 during the last 5 minutes of CPR best predicted ROSC (AUC=0.76:95% CI:0.69-0.83); rSO2≥25% provided 100% sensitivity (95%CI:94%-100%), 100% negative predictive value (NPV) (95%CI:79%-100%); rSO2 ≥65% provided: 99% specificity (95%CI:95%-100%), 93% positive predictive value (PPV) (95%CI:66%-100%) for ROSC. Time with rSO2&gt;50% during CPR best predicted CPC1-2 (AUC=0.79: 95%CI:0.70-0.88). Specifically, ≥60% CPR time with rSO2&gt;50% provided 77% sensitivity (95%CI:46%-95%), 72% specificity (95%CI:65%-79%) and 98% NPV (95%CI: 93%-100%) for CPC1-2. Conclusions: Cerebral oximetry allows real-time non-invasive cerebral oxygenation monitoring during CPR. Higher cerebral oxygenation during CPR is associated with ROSC and neurologically favorable survival to hospital discharge. Achieving higher rSO2 during resuscitation may optimize the chances of CA favorable outcomes.
"Butazolidin"
Authors: M. Kelly
Journal: BMJ (1953)

<b>Purpose:</b> To explore whether evidence of pathogenicity from prior variant classifications in ClinVar could be used to inform variant interpretation using the ACMG/AMP clinical guidelines. <b>Methods:</b> We identify distinct SNVs which are either similar in location or in functional consequence to pathogenic variants in ClinVar, and analyze evidence in support of pathogenicity using three interpretation criteria. <b>Results:</b> Thousands of variants, including many in clinically actionable disease genes (ACMG SFv3.0), have evidence of pathogenicity from existing variant classifications, accounting for 2.5% of non-synonymous SNVs within ClinVar. Notably, there are many variants with uncertain or conflicting classifications which cause the same amino acid substitution as other pathogenic variants (PS1, N=323), variants which are predicted to cause different amino acid substitutions in the same codon as pathogenic variants (PM5, N=7,692), and LOF variants which are present in genes where many LOF variants are classified as pathogenic (PVS1, N=3,635). The majority of these variants have similar computational predictions of pathogenicity and splicing impact as their associated pathogenic variants. <b>Conclusion:</b> Broadly, over 1.4 million SNVs exome-wide could make use of information from previously classified pathogenic variants. We have developed a pipeline to identify variants meeting these criteria, which may inform interpretation efforts.
Infectious and Parasitic Diseases, Their Cause and Manner of Transmission.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PARIS
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dipsticks for Diagnosis of Urinary Tract Infection in the Nursing Home
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Epidemiology of insect venom sensitivity
Authors: D. B. Golden
Journal: JAMA (1989)

The prevalence of insect sting reaction and of venom sensitization in adults is unknown. We report the results of intake evaluation of a stratified random sample of a large adult population previously studied for the determinants of atopic disease. In 269 subjects, the prevalence of systemic allergic sting reactions was 3.3% and 26.5% had IgE antibodies to venom demonstrated by skin test or radioallergosorbent test. Asymptomatic sensitization (positive venom skin test) was observed in 15% of subjects with no history of an allergic sting reaction. Positive venom skin tests were more frequent in men, in those with positive skin tests to inhalant allergens, and in subjects aged 20 through 29 years. A positive venom skin test or radioallergosorbent test was more frequent in subjects who had been stung within the previous 3 years (35%) than in those stung more than 3 years before (20%). We conclude that both systemic allergic reactions to insect stings and asymptomatic sensitivity to venom are common and that most affected persons never seek medical advice. The significance of asymptomatic venom sensitization is unknown. (<i>JAMA</i>1989;262:240-244)
Clinical Cytopathology for Pathologists—1984 Postgraduate Course
Journal: JNCI Journal of the National Cancer Institute (1983)

Journal Article Clinical Cytopathology for Pathologists—1984 Postgraduate Course Get access JNCI: Journal of the National Cancer Institute, Volume 71, Issue 4, October 1983, Page 877, https://doi.org/10.1093/jnci/71.4.877-c Published: 01 October 1983
Medical News
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal