tbuckley/cabot-search huggingface dataset:
Abstract 3566: <i>SLCO4A1-AS1</i> promotes tumorigenesis of colorectal cancer by stabilizing <i>SLCO4A1</i>
Authors: Yuri Choi, Chae Hwa Kwon, Seon Jin Lee, Daye Jeon, Do Youn Park, Sojeong Lee, Ahrong Kim
Journal: Cancer Research (2019)

Abstract Long noncoding RNAs (lncRNAs) constitute an important component of tumor biology, but the molecular mechanism through lncRNAs modulating colorectal cancer (CRC) development and progression remains unclear. Herein we analyzed RNA sequencing data of CRC patients (147 tumor and 47 matched normal tissues) to identify significant lncRNAs involved in CRC. We found 6032 lncRNAs (15%) and selected three up-expressed (ELFN1-AS1, SLCO4A1-AS1, and LINC02418) and six down-expressed (MIR22HG, BCYRN1, SATB2-AS1, LINC01752, CMAHP, and LINC01082) lncRNAs according to fold change and p-value. In Kaplan-Meier survival analysis, CRC patients with high expression of SLCO4A1-AS1 had poorer prognosis than the patients with low expression of SLCO4A1-AS1, and the other lncRNA expressions were not associated with prognosis. To concentrate on the biological function of SLCO4A1-AS1, we investigated the relationship between SLCO4A1-AS1 and SLCO4A1. They were validated in tumor and normal tissues by qRT-PCR and SLCO4A1 expression was also confirmed by immunohistochemistry, indicating their positive correlation. After knocking down of SLCO4A1-AS1, SLCO4A1 protein level was decreased and cell proliferation was suppressed in CRC cell lines. However, SLCO4A1-AS1 level was not changed by knock-down of SLCO4A1. It demonstrated that SLCO4A1-AS1 plays oncogenic role through influencing on SLCO4A1. Thus, SLCO4A1-AS1 might be useful biomarkers for CRC diagnosis and prognosis. Note: This abstract was not presented at the meeting. Citation Format: Yuri Choi, Chae Hwa Kwon, Seon Jin Lee, Daye Jeon, Do Youn Park, Sojeong Lee, Ahrong Kim. SLCO4A1-AS1 promotes tumorigenesis of colorectal cancer by stabilizing SLCO4A1 [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3566.
Two Cats
Authors: M. Therese Southgate
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The physical and psychological sequelae of torture. Symptomatology and diagnosis
Authors: A. E. Goldfeld
Journal: JAMA (1988)

We present a review of the international literature on the medical and psychological effects of torture. Our review reveals that certain tortures and their physical and emotional sequelae are more prevalent than previously appreciated. They include the common occurrence of sexual violence during the torture of women and female adolescents and the high frequency of head injury and associated neuropsychiatric consequences. We recommend the use of standardized diagnostic criteria in the evaluation of patients who have survived torture; this will facilitate patient care and the documentation of human rights violations. (<i>JAMA</i>1988;259:2725-2729)
ABSTRACTS
Authors: H Crosby, Abstracters Akeroyd, Rex Huff, A Bagdasarov, U Michael, A Jamra, Sao Paulo, T Bothwell, Wallace Jensen, Walter Cervoni, San Juan, P Oliver, P Jones, Jyoti Chatterjea, Kazuo Miyoshi, Jean Dausset, Arno Motulsky, C De Cruelly, Niilos Netousek, Pietro De Nicola, Henry Rappaport, Solomon Estren, Rudi Schmid, Boston Girdwood, Martin Seip, Nathan Smith, Wis Theodore, H Spaet, Nancy Drury, F Geoghegan, C Dixit, B Mod, H Jhala, J Parekh, G Ramasarma
Journal: Blood (1958)
Primary hormonal therapy with exemestane in patients with breast tumors &gt;3 cm in diameter: Results of a Spanish multicenter phase II trial
Authors: M. J. Gil Gil, A. Barnadas, L. Cirera, I. Tusquets, M. Muñoz, A. Arcusa, L. Prieto, A. Moreno, J. Graupera, M. Margeli
Journal: Journal of Clinical Oncology (2004)

603
Validation Study of the Accuracy of a Postoperative Nomogram for Recurrence After Radical Prostatectomy for Localized Prostate Cancer
Authors: M. Graefen
Journal: Journal of Clinical Oncology (2002)

PURPOSE: A postoperative nomogram for prostate cancer was developed at Baylor College of Medicine. This nomogram uses readily available clinical and pathologic variables to predict 7-year freedom from recurrence after radical prostatectomy. We evaluated the predictive accuracy of the nomogram when applied to patients of four international institutions. PATIENTS AND METHODS: Clinical and pathologic data of 2,908 patients were supplied for validation, and 2,465 complete records were used. Nomogram-predicted probabilities of 7-year freedom from recurrence were compared with actual follow-up in two ways. First, the area under the receiver operating characteristic curve (AUC) was calculated for all patients and stratified by the time period of surgery. Second, calibration of the nomogram was achieved by comparing the predicted freedom from recurrence with that of an ideal nomogram. For patients in whom the pathologic report does not distinguish between focal and established extracapsular extension (an input variable of the nomogram), two separate calculations were performed assuming one or the other. RESULTS: The overall AUC was 0.80 when applied to the validation data set, with individual institution AUCs ranging from 0.77 to 0.82. The predictive accuracy of the nomogram was apparently higher in patients who were operated on between 1997 and 2000 (AUC, 0.83) compared with those treated between 1987 and 1996 (AUC, 0.78). Nomogram predictions of 7-year freedom from recurrence were within 10% of an ideal nomogram. CONCLUSION: The postoperative Baylor nomogram was accurate when applied at international treatment institutions. Our results suggest that accurate predictions may be expected when using this nomogram across different patient populations.
MEDICAL STUDENT REPUTATIONS.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dye Bias Correction in Dual-labeled cDNA Microarray Gene Expression Measurements
Authors: Barry A. Rosenzweig, P. Scott Pine, Olen E. Domon, Suzanne M. Morris, James J. Chen, Frank D. Sistare
Journal: Environmental Health Perspectives (2004)

A significant limitation to the analytical accuracy and precision of dual-labeled spotted cDNA microarrays is the signal error due to dye bias.Transcript-dependent dye bias may be due to genespecific differences of incorporation of two distinctly different chemical dyes and the resultant differential hybridization efficiencies of these two chemically different targets for the same probe.Several approaches were used to assess and minimize the effects of dye bias on fluorescent hybridization signals and maximize the experimental design efficiency of a cell culture experiment.Dye bias was measured at the individual transcript level within each batch of simultaneously processed arrays by replicate dual-labeled split-control sample hybridizations and accounted for a significant component of fluorescent signal differences.This transcript-dependent dye bias alone could introduce unacceptably high numbers of both false-positive and false-negative signals.We found that within a given set of concurrently processed hybridizations, the bias is remarkably consistent and therefore measurable and correctable.The additional microarrays and reagents required for paired technical replicate dye-swap corrections commonly performed to control for dye bias could be costly to end users.Incorporating split-control microarrays within a set of concurrently processed hybridizations to specifically measure dye bias can eliminate the need for technical dye swap replicates and reduce microarray and reagent costs while maintaining experimental accuracy and technical precision.These data support a practical and more efficient experimental design to measure and mathematically correct for dye bias.
Medical school uncorks alcoholism education
Authors: E. R. Gonzalez
Journal: JAMA (1982)

How do you get your medical students to want to deal with alcoholics? "I don't think we want them to<i>want</i>to deal with alcoholics," responds Trevor Price, MD, associate professor of psychiatry and assistant professor of medicine, Dartmouth Medical School, Hanover, NH. "We don't ask them to love alcoholics or love the disease or want to be specialists in the area. What we want them to do is simply to approach it like any other disease." Price is director, and Jean Kinney, MSW, assistant professor of psychiatry, co-director of a four-year-old project that has sought to integrate alcoholism education into Dartmouth's medical school curriculum. The project was fueled by a grant of approximately $1 million from Operation Cork, an arm of The Kroc Foundation. The objective: a revised curriculum to serve as a model for other medical schools and to grow organically from the roots of expertise already present
Erratum: IL-1 is a critical regulator of group 2 innate lymphoid cell function and plasticity
Authors: Yoichiro Ohne, Jonathan S Silver, LuAnn Thompson-Snipes, Magalie A Collet, Jean Philippe Blanck, Brandi L Cantarel, Alan M Copenhaver, Alison A Humbles, Yong-Jun Liu
Journal: Nature Immunology (2016)
Nobel Laureates Enlighten a Collegiate Town
Authors: J. Torpy
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Chekhov's Doctors
Authors: Brian P. Pace
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
(6) Dyskeratosis congenita
Authors: J. M. Gartside
Journal: British Journal of Dermatology (1978)

Journal Article (6) Dyskeratosis congenita Get access J. M. Gartside J. M. Gartside Derbyshire Royal Infirmary, Derby Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 98, Issue s16, 1 July 1978, Page 31, https://doi.org/10.1111/j.1365-2133.1978.tb13608.x Published: 01 July 1978
Keloids
Authors: Brian Berman, Harlan C Bieley
Journal: Journal of the American Academy of Dermatology (1995)

I. DefinitionA keloid is as an overgrowth of dense, fibrous tissue, usually developing after healing of a skin injury.This tissue extends beyond the borders of the original wound, does not regress spontaneously, and tends to recur after excision.II.Historical background A. Keloids were first described in the Smith papyrus about 1700 Be.B. Rooted in African folklore, the Yorubas of Western Nigeria depicted keloids in sculpture as early as the 13th century.C. The first clear description of a keloid was given by Alibert in 1806.He proposed the term cheloide in 1816, to differentiate keloids from cancerous growths.The term is derived from the Greek word chele, meaning "crab claw," referring to the manner in which lesions grow laterally into normal tissue.In 1825, Alibert entitled a chapter on these lesions Les Cancroides ou Keloides.III.Clinical background A. Keloid formation is principally limited to the dermis, except for the rare keloid of the cornea.Most appear within a year after local trauma, although history sometimes fails to identify any preceding injury.Presenting signs and symptoms include cosmetic disfigurement, pruritus, pain, skin discoloration, and restriction of movement.Most frequently involved sites are the chest, shoulders, head-neck areas (especially ear lobes), arms, and upper back.B. Epidemiology 1. Appears to run in families
Outbreaks of Cyclosporiasis—United States, 1997
Journal: JAMA (1997)

In April and May 1997, CDC received reports of seven event-associated clusters of cases of cyclosporiasis from five states (California, Florida, Nevada, New York, and Texas). Approximately 80 cases of infection with human-associated Cyclospora, a recently characterized coccidian parasite have been laboratory-confirmed. State and local health departments, CDC, and the Food and Drug Administration are conducting investigations to identify the vehicles of infection.
WILD BEASTS IN INDIA.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction: Simple treatment for night terrors
Authors: S Obaro
Journal: BMJ (1993)

increased intracranial pressure is invariably present in acute meningeal inflammation' and lumbar puncture should always be undertaken with caution.Theoretically, the risk of precipitating sudden intracranial pressure loss may be reduced by minimal physical restraint and avoiding neck flexion; use of a small bore needle; obtaining a minimal volume of cerebrospinal fluid (less than 1 ml); and retracting skin from the puncture site before removing the needle and thereafter generously applying collodion to pre- vent leakage of cerebrospinal fluid after puncture.
The autopsy in clinical quality control
Authors: A. G. Scottolini
Journal: JAMA (1983)

The postmortem examination, despite declining rates, remains the final word in diagnostic quality control and a major tool in research and education. In 100 autopsies studied at our institution, it was found that 13% of major clinical diagnoses were not confirmed, and in 24% the cause of death was not in the clinical diagnoses. These figures demonstrate a higher clinical diagnostic accuracy rate than in previous studies, and the possible reasons for this are discussed. The length of hospital stay is not found to have any bearing on diagnostic accuracy. (<i>JAMA</i>1983;250:1192-1194)
Physiotherapy for airway clearance in paediatrics
Authors: B. Oberwaldner
Journal: European Respiratory Journal (2000)

The basic therapeutic principles in paediatric chest physiotherapy (CPT) are identical to those applied in adults. However, the child9s growth and development results in continuing changes in respiratory structure and function, and the requirement for different applications of CPT in each age group. Forced expiratory manoeuvres and coughing serve as basic mechanisms for mobilization and transport of secretions, but the reduced bronchial stability after birth requires special techniques in very young patients. High externally applied transthoracic pressures have to be avoided in order to prevent interruption of airflow. In addition, airway patency is maintained by the application of back pressure and by liberal use of continuous positive airway pressure. Since sympathomimetic bronchodilators might further decrease bronchial stability, their use must be individualized in newborns and young infants. Inspiration is a basic mechanism for inflating alveolar space behind obstructing mucus plugs. Due to a highly unstable chest, the premature baby, newborn and infant cannot distend their lung parenchyma to the same extent as can older patients. Consequently all chest physiotherapy strategies applied in this age group have to incorporate appropriate techniques for raising lung volume. Positioning serves to redistribute ventilation, but the young infant9s response to gravitational forces differs substantially from that of the adult, and consequently strategies used in older patients have to be modified. In addition, the therapist has to consider pathology such as bronchial instability lesions and airway hyperresponsiveness and has to adjust the therapeutic response accordingly. It is particularly important to consider the special vulnerability of newborns and young infants and to modify therapeutic interventions to avoid the harm that could otherwise be inflicted. Consideration of these differences between infant, child and adult and careful analysis of the available mucus clearance techniques allows tailoring of an individualized therapeutic approach to the paediatric patient.
Inhibition of hepatitis B virus DNA polymerase by enantiomers of penciclovir triphosphate and metabolic basis for selective inhibition of HBV replication by penciclovir
Authors: T Shaw
Journal: Hepatology (1996)

The deoxyguanosine analog penciclovir (PCV; 9-[4-hydroxy-3-hydroxymethyl-but-1-yl]guanine), has shown potent antiviral activity against herpes viruses and hepadnaviruses. Efficacy against chronic hepatitis B virus (HBV) infection has been demonstrated in an animal model and in recent clinical trials of famciclovir, the oral form of PCV. The antiviral activity of PCV is believed to be dependent on the intracellular formation of PCV-triphosphate (PCV-TP) which is presumed to inhibit HBV replication by interfering with viral DNA polymerase activity. The (S)-enantiomer is preferentially formed in herpes virus-infected cells, and is the more active against the herpes simplex virus; however, little is known about the biochemical mechanisms of PCV phosphorylation or of interference with viral replication in HBV-infected cells. Here, we report that in contrast with herpes simplex virus, the (R)-enantiomer of PCV-TP is a more potent inhibitor of HBV DNA polymerase-reverse transcriptase (pol-RT) in vitro than the (S)-enantiomer. In assays for HBV DNA pol-RT activity, in which purified viral core particles were the enzyme source, the IC50s for (R)- and (S)-enantiomers of PCV-TP were 2.5 micromol/L and 11 micromol/L, respectively. The estimated Kis for (R)- and (S)- PCV-TP were approximately 0.03 micromol/L and approximately .04 micromol/L, respectively, about 3-fold lower than the Km for deoxyguanosine triphosphate (dGTP) in the same system. In addition, we report that PCV metabolism is similar in both control (HepG2) and in HBV-transfected (2.2.15) hepatoblastoma cells in vitro, indicating that cellular enzyme(s) catalyze PCV phosphorylation. Peak PCV-TP concentrations of about .4 micromol/L were reached in both cell types in less than 12 hours, and intracellular PCV-TP was exceptionally stable with a half-life of about 18 hours. These observations provide a mechanistic basis for the potent activity of PCV against HBV.
Mother to infant transmission (MIT) of hepatitis C virus (HCV) , T. Nicoto; J.D. Grang�oo, B. Aublet-Cuvellier*, P. Kuder, M. Meyer**, F. Quainon***, F. Deniso, G. Bommelaer. Services d'H�patograstroent�rologie, *d'Epid�miologie, **de P�diatrie, ***CRTS Clermont-Ferrand; oLaboratoire de Virologie, Limoges; ooH�pital Tenon, Paris
Journal: Hepatology (1995)