tbuckley/cabot-search huggingface dataset:
Impotence in diabetic and non-diabetic hospital outpatients
Authors: E. Lester, A J Grant, F J Woodroffe
Journal: BMJ (1980)

One explanation of these anomalies is that talc may be acting as a particulate adjuvant, promoting cell-mediated hypersensitivity reactions to polysaccharide antigens of starch in susceptible individuals.For these reasons we would support efforts to eliminate talc, which although not directly pathogenic in low con- centration, may facilitate cell-mediated re- action to other agents on the surface of surgical gloves.
Incorrect Word.
Journal: JAMA (1996)

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Determinants of Serum Zinc in a Random Population Sample of Four Belgian Towns with Different Degrees of Environmental Exposure to Cadmium
Authors: Lutgarde Thijs, Jan Staessen, Antoon Amery, Pierre Bruaux, Jean-Pierre Buchet, Francoise Claeys, Pierre De Plaen, Genevieve Ducoffre, Robert Lauwerys, Paul Lijnen, Laurence Nick, Annie Saint Remy, Harry Roels, Desire Rondia, Francis Sartor
Journal: Environmental Health Perspectives (1992)

This report investigated the distribution of serum zinc and the factors determining serum zinc concentration in a large random population sample. The 1977 participants (959 men and 1018 women), 20–80 years old, constituted a stratified random sample of the population of four Belgian districts, representing two areas with low and two with high environmental exposure to cadmium. For each exposure level, a rural and an urban area were selected. The serum concentration of zinc, frequently used as an index for zinc status in human subjects, was higher in men (13.1 μmole/L, range 6.5–23.0 μmole/L) than in women (12.6 μmole/L, range 6.3–23.2 μmole/L). In men, 20% of the variance of serum zinc was explained by age (linear and squared term, R = 0.29), diurnal variation (r = 0.29), and total cholesterol (r = 0.16). After adjustment for these covariates, a negative relationship was observed between serum zinc and both blood (r = −0.10) and urinary cadmium (r = −0.14). In women, 11% of the variance could be explained by age (linear and squared term, R = 0.15), diurnal variation in serum zinc (r = 0.27), creatinine clearance (r = −0.11), log γ-glutamyltranspeptidase (r = 0.08), cholesterol (r = 0.07), contraceptive pill intake (r = −0.07), and log serum ferritin (r = 0.06). Before and after adjustment for significant covariates, serum zinc was, on average, lowest in the two districts where the body burden of cadmium, as assessed by urinary cadmium excretion, was highest. These results were not altered when subjects exposed to heavy metals at work were excluded from analysis.
Officials of the Association 1977-1978
Journal: JAMA (1978)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medical researchers and the media. Attitudes toward public dissemination of research
Authors: M S Wilkes, R L Kravitz
Journal: JAMA (1992)

<h3>Objective.</h3> —To study the experience of recently published authors with the news media. <h3>Design.</h3> —A self-administered questionnaire. <h3>Participants.</h3> —All first authors of scientific articles published in<i>JAMA and The New England Journal of Medicine</i>during a 6-month period. Of 397 surveyed, 92% responded. <h3>Main Outcome Measures.</h3> —Researchers were asked about (1) their experience with the news media, (2) their attitudes toward the dissemination of health-related research to the general public, and (3) their attitudes toward the lay press. <h3>Results.</h3> —Of respondents, 65% stated that their research was discussed in the lay press, and 60% reported that they were directly contacted by the press. Researchers had positive attitudes toward the press; 86% reported that news reports based on their research were accurate and 44% felt that media coverage would help them achieve their overall professional goals. Positive aspects of media coverage most frequently endorsed were that (1) it improves the image of the profession, (2) it informs the professional community of their research, and (3) it allows the public to understand the topic better. Negative aspects of media coverage were (1)it gives the impression that the researcher is seeking publicity, (2) it creates jealousy among colleagues, and (3) it takes too much time. Researchers were not eager to change the existing dissemination process, yet they endorsed the need for uniform standards concerning relations with the press. <h3>Conclusions.</h3> —The majority of first authors in two leading medical journals reported substantial media coverage of their research, expressed generally positive sentiments about the press coverage of their work, and expressed a need for consensus on interactions involving the press. (<i>JAMA</i>. 1992;268:999-1003)
Chemodynamics: Transport and Behavior of Chemicals in the Environment. A Problem in Environmental Health
Authors: V. H. Freed, C. T. Chiou, R. Haque
Journal: Environmental Health Perspectives (1977)

In the manufacture and use of the several thousand chemicals employed by technological societies, portions of these chemicals escape or are intentionally introduced into the environment.The behavior, fate, and to some extent the effects produced by these chemicals are a result of a complex interaction of the properties of the chemical with the various processes governing transport, degradation, sequestration, and uptake by organisms.In addition, such processes as adsorption, evaporation, partitioning, and degradation are influenced by ambient conditions of temperature, air movement, moisture, presence of other chemicals, and the concentration and properties of the subject chemicals.These influence the level and extent of exposure to these chemicals that man might receive.Study of the physicochemical properties of compounds in relation to these various processes has provided a basis for better understanding of the quantitative behavior.Such information is useful in development of predictive models on behavior and fate of the chemicals in relation to human exposure.Beyond this, it provides information that could be used to devise procedures of manufacture, use, and disposal that would minimize environmental contami- nation.Some of the physical principles involved in chemodynamics are presented in this review.
Metabolic response to sodium-glucose cotransporter 2 inhibition in type 2 diabetic patients
Authors: Ele Ferrannini, Elza Muscelli, Silvia Frascerra, Simona Baldi, Andrea Mari, Tim Heise, Uli C. Broedl, Hans-Juergen Woerle
Journal: Journal of Clinical Investigation (2014)

The y axes for Figure 2, upper left panel, and Figure 5C were incorrect.
Occlusion of the renal artery secondary to acute or remote trauma
Authors: S. H. Cornell
Journal: JAMA (1972)

Five patients with traumatic occlusion of the renal artery were seen during a three-year period. The injury was recent in four and remote in one. A traumatized kidney not visualized on the excretory urogram but showing no distortion of the collecting system on the retrograde pyelogram should be studied by renal arteriography. If the obstruction is incomplete, repair of the renal artery with restoration of normal blood flow might be possible. A severely ischemic kidney must be removed to prevent the development of infection and hypertension. The arteriogram should be examined for evidence of associated injury to the patient such as splenic or hepatic laceration.
Iron deficiency anemia: have we come far enough?
Authors: J. A. Stockman
Journal: JAMA (1987)

In the progress of medical science, a disease is recognized, its manifestations are elucidated, and treatments or preventive measures are instituted; we then hope that the problem might become one of historical interest. Sometimes, however, we fail to realize when the problem still exists, and by our therapeutic misadventures create new problems. As demonstrated by the article of Yip et al<sup>1</sup>in this issue ofThe Journal, we indeed have come a long way in dealing with the problem of iron-deficiency anemia in childhood. When viewing the declining prevalence of anemia among low-income children in the United States, we should ask, however, if we have come far enough. To answer, it is useful to understand where we have been, where we are now, and in what directions we could be moving with respect to the prevention of iron deficiency. Iron is among the most common and useful of all
Miscellany
Journal: JAMA (1921)

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James Blundell (1790-1877) physiologist and obstetrician
Journal: JAMA (1968)

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Contents page + Editorial Board
Authors: Stephanie Cragg, Laurent Groc, Bengt Gustafsson, Eric Hanse, Ve ´ronique Bernard, Marion De ´cossas, Isabel Liste, Bertrand Bloch, Arthur Toga, Paul Thompson, Elizabeth Sowell, Thomas Kno, Javier Dı ´ez-Garcı ´a, Walther Akemann, Yuri Bozzi, Emiliana Borrelli, Roger Albin, Jonathan Mink Trendsin, Sian Lewis, Heather Yeomans, Patrick Liu, Manager Moulton
Journal: Trends in Neurosciences (2006)
A phase I, first-in-human, open-label, dose-escalation, safety, pharmacokinetic, and pharmacodynamic study of oral TP-1287 administered daily to patients with advanced solid tumors.
Authors: Ben George, Donald A. Richards, William Jeffery Edenfield, Steven L Warner, Lars Mouritsen, Reyna Bishop, Stephen Patrick Anthony, David Bearss, Nicholas J. Vogelzang, Clifford Whatcott
Journal: Journal of Clinical Oncology (2020)

3611 Background: TP-1287 is a an orally bioavailable phosphate prodrug of alvocidib, a cyclin dependent kinase 9 (CDK9) inhibitor. TP-1287 exhibits potent inhibition of intracellular kinases including CDK9. Inhibition of CDK9 leads to downregulation of the BCL-2 family member, MCL-1, which in turn inhibits tumor growth in preclinical animal models of prostate, breast, and lung carcinomas. Methods: This is a multicenter, Phase 1, dose escalation study using a standard 3+3 design with a modified Fibonacci scheme to examine the safety and clinical activity of TP-1287 in patients with advanced solid tumors. Patients will be added at the maximum tolerated dose (i.e. expansion cohort) to test TP-1287 as a single agent in patients with castrate resistant prostate cancer. Results: Twenty-two patients who were enrolled between December 2018 and January 2020 received a range of doses from 1 mg QD to 11 mg BID over 7 cohorts. Data are available for 20 patients as of the data cutoff date. TP-1287 plasma PK C max and AUC increased in near linear fashion over cohorts 1 thru 6, reaching 80 ng/mL and 499.3 ng*h/mL in cohort 6 for C max and AUC, respectively. TP-1287 treatment resulted in dose-dependent reductions of phospho-RNA Pol II, consistent with CDK9 inhibition, as measured by a flow cytometric assay assessing pharmacodynamic changes in phosphorylation state in PBMCs. The most frequently observed Grade 3 AE was unrelated anemia in 2 patients. All other events of Grade 3 (9 events/7 patients) and Grade 4 (1 event/seizure with new CNS mets) were unlikely related or unrelated. Clinical benefit was seen in one sarcoma patient with PR (15+cycles), one RCC patient with SD (7+cycles) and 2 bladder cancer patients with SD (6 and 8 cycles). Conclusions: These findings suggest that TP-1287 is tolerated as a monotherapy in patients with heavily pretreated, relapsed, refractory solid tumors and further clinical development in selected indications is warranted. Clinical trial information: NCT03298984 .
Clinical Experience with the Monoamine Oxidase Inhibitor, DL-Serine-N2-Isopropylhydrazide (RO 4-1038), in the Treatment of Hypertension
Journal: JAMA (1963)

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Reply
Authors: J M Rhodes
Journal: Gut (1990)

SIR, -I am sorry that Professor Jass's excellent papers were not referred to in my leading article.This was, however, intended as a presentation of hypotheses to act as stimuli for further studies rather than as a comprehensive review ofpublished work.As pointed out in the article a change in the 0 acetylation of mucin sialic acids is just one of many potential alterations in mucin structure that could have an effect on its interaction with bacteria.Others include alterations in sulphation, sialylation, length, and branching of oligosaccharide side chains and changes in the expression of carbohydrate receptors for bacterial adherence lectins.
Neurosyphilis
Journal: JAMA (1972)

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GENETIC EVOLUTION PATTERNS IN PATIENTS WITH CHRONIC MYELOMONOCYTIC LEUKEMIA TO SECONDARY ACUTE MYELOID LEUKEMIA: AN ANALYSIS OF 36 PAIRED SAMPLES
Authors: Y.-J. Su, M.-C. Kuo, P.-N. Wang, J.-H. Wu, T.-H. Lin, T.-Y. Huang, T.-L. Lin, H. Chang, Y.-S. Hung, L.-Y. Shih
Journal: HemaSphere (2019)
Yale Journal of Biology and Medicine, New Haven
Journal: JAMA (1965)

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Whole-body counters
Authors: A. P. Remenchik
Journal: JAMA (1966)

Whole-body counters are sensitive radiation-detecting and measuring instruments developed by radiation physicists for determining the amount of radioactivity present in man. Quickly and painlessly they enable the investigator to determine the kinds and amounts of radioactive substances in the body which have accumulated from natural sources, manmade fallout, industrial and laboratory sources, or from tracer isotopes given for medical purposes. This is done by counting emissions from the radioactive material in the body. From a physical point of view these devices do not differ materially from the instruments most physicians are familiar with that are used to assay for radioactivity in body fluids and tissues. They differ from these devices only by their large size, their heavy shielding, and their sensitivity to very low levels of radioactivity. Two principal types of wholebody counters have been developed. One uses a sodium iodide crystal as a radiation detector, and in the other
Clinical &amp;amp; Laboratory Studies with Sodium Diphenicillin II. Clinical Studies, with Emphasis on the Rate of Disappearance of Staphylococci from Various Lesions
Journal: JAMA (1963)

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