tbuckley/cabot-search huggingface dataset:
Encephalopathy following jejunoileostomy
Authors: R. Catlin
Journal: JAMA (1982)

<h3>To the Editor.—</h3> Our health care system has spawned a rise in costs that is rightfully alarming the nation. Unquestionably, physicians are responsible. We as physicians allocate the finances that are available for health expenditures; ie, we decide what diagnostic and treatment modalities will be purchased. Unless we stop the rising costs, our professional freedom will be lost in the coming public and private reactions. Furthermore, health expenditure per physician will decline even with no overt wresting of power from physician to legislators and thirdparty creditors. Economic forces that presently exist are enough to ensure it.<sup>1</sup> Therefore, physicians must reevaluate methods of diagnosis and treatment to provide maximum health care per dollar expended. As an example of a possible solution, we examined the "routine" preoperative upper gastrointestinal series (UGIS) for people with documented gallbladder (GB) disease. This is a procedure universally recommended to rule out a concomitant pathological condition.
Rational suicide: no longer 'crazy'?
Authors: P. Cotton
Journal: JAMA (1993)

RATIONAL SUICIDE tends to be described as either a right or an oxymoron. The medical community has long taken the latter view, officially condemning any physician who helps a terminally ill patient end his or her suffering by any other than natural means. Yet that may be changing. See also pp 870, 874, and 875. In Michigan, the state medical society this year officially took the position of having no position on physician-assisted suicide, saying that it is "not possible to develop a single, consensual statement." The issue has urgency there because of several suicides assisted in the state by Jack Kevorkian, MD, and a new state law that makes physician-assisted suicide a felony. The issue is also being discussed with renewed vigor nationwide, with proposals to legalize physician-assisted suicide narrowly defeated last year in Washington and California. Ambivalence is evident even in the American Association of Suicidology (AAS), an
Top ACS Executive Resigns
Journal: JNCI Journal of the National Cancer Institute (1991)

Journal Article Top ACS Executive Resigns Get access JNCI: Journal of the National Cancer Institute, Volume 83, Issue 19, 2 October 1991, Page 1379, https://doi.org/10.1093/jnci/83.19.1379-a Published: 02 October 1991
Basal Cell and Squamous Cell Carcinoma in Persons Younger Than 40 Years
Authors: Chad T Wilson
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
J Clinical Endocrinology, Philadelphia
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Metastatic neuroblastoma confined to distant lymph nodes (stage 4N) to predict outcome in patients with stage 4 disease: A study from the International Neuroblastoma (NB) Risk Group (INRG) Database.
Authors: Daniel Alexander Morgenstern, Wendy B. London, Derek Stephens, Samuel Louis Volchenboum, Barabara Hero, Andrea Di Cataldo, Akira Nakagawara, Hiroyuki Shimada, Peter F Ambros, Katherine K. Matthay, Susan Lerner Cohn, Andrew DJ Pearson, Meredith Irwin
Journal: Journal of Clinical Oncology (2013)

10015 Background: Patients with metastatic NB typically have a poor prognosis; however case series have suggested that those with 4N disease may have improved outcomes. Methods: Retrospective analysis of data from INRG database for patients diagnosed 1990–2002. 4N patients (INSS stage 4 disease confined to distant lymph nodes) were compared to the balance of stage 4 patients (‘non-4N’), excluding those with missing metastatic site data. 5-yr estimates of overall (OS) and event-free survival (EFS) were calculated ± standard error (Kaplan-Meier method). Patient characteristics were compared by Mann-Whitney or Fisher’s exact/Chi-square tests. Results: 2,250 INSS stage 4 patients with complete data were identified, of whom 146 (6%) had 4N disease. For 4N patients, EFS and OS (5-yr: 77% ± 4%, 85% ± 3%), were significantly better than EFS and OS (5-yr: 35% ± 1%, 42% ± 1%) for non-4N stage 4 patients (p&lt;0.0001). 4N patients were more likely to be younger (median age at diagnosis 1.2 yr vs 2.5 yr for non-4N; p&lt;0.0001) and have tumors with favourable International Neuroblastoma Pathologic Classification (INPC) (63% vs 26%, p&lt;0.0001), differentiating grade (21% vs 8%, p=0.006), lower MKI (p=0.0011) and non-MYCN amplified tumors (89% vs 69%, p&lt;0.0001). Within subgroups defined by age at diagnosis and MYCN status, 4N pattern of disease remained significantly associated with improved outcomes. For patients aged ≥547 days at diagnosis and MYCN non-amplified, 5-yr EFS for 4N patients (n=42) was 63% ± 8% vs 27% ± 2% for non-4N (n=785); OS 74% ± 7% vs 38% ± 2% (both p&lt;0.0001). Within this subgroup, favourable INPC and differentiating grade remained more frequent in the 4N vs non-4N patients (45% vs 10%, p&lt;0.0001; 45% vs 8%, p=0.0017, respectively). Conclusions: 4N represents a subgroup of metastatic patients with better outcome than other INSS stage 4 patients. These findings indicate that the biology and response to treatment of 4N tumors differs from other stage 4 tumors, and different therapies should be considered for this cohort. Future exploration of biological factors determining pattern of metastatic spread and response to therapy is warranted.
Cold agglutinins accompanying Mycoplasma pneumoniae infection
Authors: G N Smith, W C R Weir
Journal: BMJ (1981)

interesting to know the results.Two points about tuberculosis in Indochinese refugees are worth noting.Experience with Vietnamese refugees in the United States' shows that the infection rate for tuberculosis is exceedingly high.The overall incidence of tuberculosis among the population of Louisiana in 1979 was 16 per 100 000 (ranging from 5/100 000 for white females to 43/100 000 for black males).In a study of 99 321 refugees from Indochina the incidence of tuberculosis was 926/100 000.In another study' of 86 548 Vietnamese refugees 50%/, had positive Mantoux tests, 2975 had active tuberculosis, and 1897 had inactive tuberculo- sis according to chest x-ray examination and sputum examination.The second point to note is that the Myco- bacterium tuberculosis organisms isolated from Vietnamese refugee immigrants showed a very high incidence of resistance to the common anti-tuberculosis drugs.In a study by Byrd et al on tuberculosis in immigrants2 from Korea, Thailand, Japan and the Philippines, Vietnam, and China, the overall incidence of resistance to isoniazid was 58 0, to streptomycin 360), and to p-aminosalicylic acid 14%,, multiple resistance occurring in 36%' of isolates.Those organisms isolated from the Vietnamese showed a still worse pattern of resistance: only 170% of organisms were fully sensitive and 33 0 showed multiple resistance.The figures for resistance to individual drugs were: isoniazid-50 0,) streptomycin-67%, p-aminosalicylic acid-170o.No organisms isolated from the Vietnamese were resistant to either rifampin or ethambutol.
Opodeldoc
Authors: Sam A. Nixon
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sustained virologic response to direct-acting antivirals does affect the risk of portal vein thrombosis in patients with advanced chronic liver disease
Authors: Mattias Mandorfer, Fanny Turon, Sabela Lens, Anna Baiges, José Ferrusquia, Marta Magaz, David JM Bauer, Pol Olivas, Zoe Mariño, Xavier Forns, Virginia Hernandez-Gea, Juan Carlos Garcia Pagan
Journal: Journal of Hepatology (2020)
PRE-COLUMBIAN LEPROSY.
Authors: ALBERT S. ASHMEAD
Journal: JAMA (1895)

I print here, side by side, photographs of loss of nose deformation by lupus, by syphilis, by leprosy. The leper apparently has lost his upper lip, with his nose. This last is taken from Leloir's well-known work. I also print the characteristic deformations of fingers and toes of lepers, according to photographs sent me by Dr. Morrow. I print also photographs of<i>huacos</i>pottery, representing deformations. Also a photograph showing leprous tuberculation of the face. This mutilation of the fingers, and this tuberculation of the face, are the most striking features of the disease. Is it not probable, therefore, that if those ancient Peruvians had intended to represent leprosy in the<i>huacos</i>pottery they would have shown a tuberculated face or a deformed hand? There lives in France (Béarn), in the Pyreneean regions, a class of people called Cagots, who have deformations of the finger- and toe-tips, elevated and arched
Lettsomian Lectures on Syphilis as a Cause of Disease of the Nervous System
Authors: W. H. Broadbent
Journal: BMJ (1874)

Syphilitic Affections of the AMedulla Oblongata and Pons.-The intra- cranial prolongation of the spinal cord forming the medulla oblongata and pons Varolii is complicated in its structure and function, not only by the separation of the nerve-nuclei from each other, in accordance with the specialisation of their functions, but by the change in the rela- tions of the grey matter and tracts of white fibres with each other, the decussation of the motor tracts, and the connection of the cerebellum with the spinal axis which is here effected.The consequences of lesions here are, therefore, more varied, and the causes which may give rise to them are increased in number.These parts, for example, may be affected by disease in the cerebellum, or by aneurism of the basilar artery.The increased dimensions of the spinal axis, moreover, permit uni- lateral limitation of a morbid change; and this is not uncommon, although the two halves are fused together, while unilateral mischief is rarely seen in the cord, which is almost completely divided longi- tudinally by the fissures.Possibly, however, the vascular membrane which dips into the fissures is more efficient in communicating a morbid change than the nervous structures.The general results of disease in the medulla and pons are some in- terference with the sensory or motor tract, proceeding from the cord to the sensori-motor ganglia, together with disturbance or abolition of the function of one or more of the nerve-nuclei.It is seldom that we can come to the conclusion that there is disease here from sensory or motor paralysis of the limbs alone, or from affections of the nerves which have their origin in the intracranial part of the spinal axis alone, al- tlsough this may be done occasionally when two nerves are simul- taneously paralysed, the nuclei of which are conjoined or in close proximity, while the nerves take a different course after their emergence from the centre, as in the case of the sixth and seventh.The group.ing of symptoms arising from the inclusion in a diseased area of several nerve-nuclei may be very varied; usually, the symptoms afford the means of making a very precise localisation of the lesion by the application of anatomical and physiological knowledge.Of course, disease here is attended with great danger to life, the slightest interference with the reflex centres of the respiratory and cardiac movements being fatal.Sudden death is, therefore, common.
Abstract 3655: Mapping the osteogenic lineage and identification of the cell of origin of osteosarcoma through high-dimensional analysis
Authors: Yifei Wang, Sankaranarayanan Kannan, Zhongting Zhang, Wendong Zhang, Michael Roth, Jonathan B. Gill, Zhaohui Xu, Xiangjun Tian, Jing Wang, Richard Gorlick
Journal: Cancer Research (2019)

Abstract Osteosarcoma (OS) is the most common primary malignant bone tumor in children and young adults. Neo-adjuvant chemotherapy combined with wide resection increased the 5-year survival rate to 60%-70%. However, treatment and outcome of OS have not changed in several decades. OS is histologically defined by the presence of malignant osteoid, suggesting it could be derived from anywhere in the osteogenic lineage between mesenchymal stem cells (MSC) and mature osteoblasts, but the cell of origin of OS is still undefined. Tracing the cells from which most cancers formed are characterized by its multipotent and/or unipotent stem cell nature. Studies on the cellular origin of tumors from phenotypic lineage-tracking and its derived progeny can reveal tissue-specific tumor-initiating cells. Investigating cell of origin of OS and osteogenic differentiation using developmentally relevant model using MSC to OB differentiation is promising. Here we developed a high-dimensional analytic pipeline using single-cell mass cytometry (CyTOF) and RNA sequencing to discover the unrecognized progenitor-osteoblast populations in the osteogenic lineage. For the data analysis, the population clustering using Flowsom and ConsensusClusterPlus on arcsinh transformed FCS data combined with t-SNE plot visualization shows that combination of CD49f, CD95, CD56, CD117 expression enables the identification and future isolation of the progenitor populations. Also, when comparing OS with the populations from MSC to OB, there are progenitor -osteoblast / mature osteoblast-like populations in tumor cells, but no MSC-like component is found. The expression level of CD56 and CD117 are significantly higher in OS compare to MSC and OB, which warrants future investigation of new therapeutic strategy. Isolation of the progenitor-osteoblast cells, gene expression comparison between OS and these progenitors, validation of their differentiation potential and tumor-initiating capacity is still underway. In this study, we developed a CyTOF based pipeline to discover the progenitor populations in the osteogenic lineage. By comparison of the OS and these progenitor cells, we may be able to unveil the cell of origin and new targeted treatment strategy of OS. Citation Format: Yifei Wang, Sankaranarayanan Kannan, Zhongting Zhang, Wendong Zhang, Michael Roth, Jonathan B. Gill, Zhaohui Xu, Xiangjun Tian, Jing Wang, Richard Gorlick. Mapping the osteogenic lineage and identification of the cell of origin of osteosarcoma through high-dimensional analysis [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3655.
Dyslipidemia
Authors: Barbara Turner
Journal: Annals of Internal Medicine (2010)

This issue provides a clinical overview of dyslipidemia focusing on prevention, diagnosis, treatment, practice improvement, and patient information. Readers can complete the accompanying CME quiz for 1.5 credits. Only ACP members and individual subscribers can access the electronic features of In the Clinic. Non-subscribers who wish to access this issue of In the Clinic can elect "Pay for View." Subscribers can receive 1.5 category 1 CME credits by completing the CME quiz that accompanies this issue of In the Clinic. The content of In the Clinic is drawn from the clinical information and education resources of the American College of Physicians (ACP), including PIER (Physicians' Information and Education Resource) and MKSAP (Medical Knowledge and Self Assessment Program). Annals of Internal Medicine editors develop In the Clinic from these primary sources in collaboration with the ACP's Medical Education and Publishing division and with assistance of science writers and physician writers. Editorial consultants from PIER and MKSAP provide expert review of the content. Readers who are interested in these primary resources for more detail can consult www.acponline.org, http://pier.acponline.org, and other resources referenced within each issue of In the Clinic.
Doctors' Wives
Authors: D. Allen
Journal: BMJ (1966)

was an unusually suitable one for consider- ing what we could do about this, while we are digesting the proposed increase in our pay.We believe that if every nine-session con- sultant contributed, say, £10 a year out of his rise, others in proportion to their sessions, and perhaps holders of merit 'awards a little more, it would make a very great difference to the recipients and very little to us.In fact, if it were automatically deducted by the regional hospital boards, most of us would not notice it.We felt that some form of automatic deduction should prove more efficient, because many of us are absent-minded andoverworked and intentions to make out covenants in favour of the Royal Medical Benevolent Fund, etc., might well fail to bear fruit.-We are, etc.,
Manual of Clinical and Laboratory Technic.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
At year's end, what's new with interferon?
Authors: W. A. Check
Journal: JAMA (1979)

Last year the American Cancer Society (ACS) announced that it was spending $2 million to purchase 40 billion units of interferon from the Finnish Red Cross, enough for American oncologists to study interferon's anticancer activity in about 150 patients. This expenditure, the largest on a single project in the society's history, was prompted by preliminary results from the United States and Sweden showing that interferon can halt or reverse the growth of osteogenic sarcoma, melanoma, breast cancer, and lymphoma in some patients. One misconception about this trial was recently discussed by Thomas Merigan, MD, of Stanford University, a codirector of the study. "Because of the expense and publicity associated with this clinical trial," he explained, "people think there will be quick answers." But, in his view, this is only the first of many clinical trials that will be needed to establish whether interferon is a useful antitumor agent. For this