tbuckley/cabot-search huggingface dataset:
Predictors of Systemic Embolism in Mitral Stenosis
Authors: Cheng-Wen Chiang
Journal: Annals of Internal Medicine (1998)

Letters15 December 1998Predictors of Systemic Embolism in Mitral StenosisCheng-Wen Chiang, MDCheng-Wen Chiang, MDChang Gung Memorial Hospital; Taipei, Taiwan, Republic of ChinaAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-129-12-199812150-00028 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSETransesophageal echocardiography has been shown to be better than TTE for detection of left atrial thrombi [1, 2]. In our subgroup of 164 patients (including 36 patients in sinus rhythm and 128 patients in atrial fibrillation) who underwent baseline TEE, the prevalence of left atrial thrombi detected by TEE was 56.7% and that by TTE was 29.9%. The difference in the occurrence of systemic embolism during follow-up between those with and those without left atrial thrombi (detected by either TTE or TEE) did not reach statistical significance in this subgroup, presumably because of the small sample and the ...References1. Mugge A, Daniel WG, Haverich A, Lichtlen PR. Diagnosis of non-infective cardiac mass lesions by two-dimensional echocardiography. Comparison of the transthoracic and transesophageal approaches. Circulation. 1991; 83:70-8. Google Scholar2. Manning WJ, Weintraub RM, Waksmonski CA, Haering JM, Rooney PS, Maslow AD, et al. Accuracy of transesophageal echocardiography for identifying left atrial thrombi. A prospective, intraoperative study. Ann Intern Med. 1995; 123:817-22. Google Scholar3. Coulshed N, Epstein EJ, McKendrick CS, Galloway RW, Walker E. Systemic embolism in mitral valve disease. Br Heart J. 1970; 32:26-34. Google Scholar4. Black IW, Fatkin D, Sagar KB, Khandheria BK, Leung DY, Galloway JM, et al. Exclusion of atrial thrombus by transesophageal echocardiography does not preclude embolism after cardioversion of atrial fibrillation. A multicenter study. Circulation. 1994; 89:2509-13. Google Scholar Author, Article, and Disclosure InformationAffiliations: Chang Gung Memorial Hospital; Taipei, Taiwan, Republic of China PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 December 1998Volume 129, Issue 12Page: 1077-1078KeywordsAnticoagulantsAtrial fibrillationEchocardiographyMitral stenosisPatient advocacy Issue Published: 15 December 1998 CopyrightCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
A new model for estimating glomerular filtration rate in patients with cancer.
Authors: Tobias Janowitz, Edward Hywel Williams, Andrea Marshall, Nicola Ainsworth, Peter B Thomas, Stephen John Sammut, Scott Thomas Colville Shepherd, Jeff D. White, Patrick Mark, Andy Lynch, Duncan Ian Jodrell, Simon Tavaré, Helena Margaret Earl
Journal: Journal of Clinical Oncology (2017)

e14074 Background: The glomerular filtration rate (GFR) is essential for carboplatin chemotherapy dosing, however, the best method to estimate GFR in patients with cancer is unknown. We identify the most accurate and least biased method. Methods: Data on age, sex, height, weight, serum creatinine, and results for GFR from 51 Cr-EDTA excretion measurements ( 51 Cr-EDTA GFR) were obtained from Caucasian patients aged 18 years or older with histologically confirmed cancer diagnoses at the University of Cambridge Hospital NHS Trust, UK. We developed a new multivariable linear model for GFR using statistical regression analysis. 51 Cr-EDTA GFR was compared to the estimated GFR (eGFR) from seven published and our new model using an internal validation data set and root-mean-squared-error (RMSE) and median residuals. A comparison of carboplatin dosing accuracy based on an absolute percentage error more than 20% (APE &gt; 20%) was undertaken. Results: Between August 2006 and January 2013 data from 2,471 patients were obtained. The new model improved the eGFR accuracy (RMSE 15.00ml/min (95% CI 14.12-16.00)) compared to all published models. Body surface area (BSA) adjusted CKD-EPI was the most accurate published models for eGFR (RMSE 16.30ml/min (95% CI 15.34-17.38)) for the internal validation set. Importantly, the new model reduced the fraction of patients with a carboplatin dose APE &gt; 20% to 14.17% in contrast to 18.62% for BSA adjusted CKD-EPI and 25.51% for the Cockcroft-Gault model. The results were externally validated. Conclusions: In a large data set, from patients with cancer, a new model improves eGFR and carboplatin dose calculations, when compared to BSA adjusted CKD-EPI, the model we identified as the best published model for determination of eGFR in patients with cancer.
Medicine: For the Practicing Physician
Authors: John J. Massarelli
Journal: JAMA (1990)

<b>Criteria for Diagnosis,</b>edited by J. Willis Hurst, 603 pp, paper, $29.95, ISBN 0-409-901504-4, Stoneham, Mass, Butterworths, 1989. <i>Medicine: For the Practicing Physician</i>is the second edition of a big textbook of medicine that is different from all the others in that it is completely problem oriented. Dr J. Willis Hurst, the editor-in-chief, said in his preface to the first edition, "It will take time and effort to polish up the start that has been made with this edition, but we are determined to do so." He has indeed come through as promised with a considerably improved product. The number of editors remains the same, 29, including Dr Hurst. Although there are fewer total pages (1857 vs 1969), the amount of information is larger because the print is smaller and space is better utilized; this does not detract from the appearance or readability of the text. The number of contributors
Internists eye sophisticated science
Authors: R. Voelker
Journal: JAMA (1994)

BIOTECHNOLOGY. It's not just for gene splicers anymore. In the United States last year, 1300 biotechnology companies were up and running. During 1993 they raised $3 billion in new capital in the stock market, their second-best annual performance. Sales of at least two biotech drugs— erythropoietin and colony-stimulating factor—exceed $1 billion annually. So after dealing handily with the stock market and pharmaceutical development, internal medicine isn't far off on the horizon. But internists needn't become molecular experts. Awareness of diagnostic methods and treatment tools produced through biotechnology's advances is the goal. "The message for the general internist is that you can't keep up with all of it," says Ian Hart, MD, professor of medicine at the University of Ottawa (Ontario) Faculty of Medicine. Nevertheless, he detailed a sampling of new challenges and promising technologies in disease diagnosis and treatment during the annual meeting of the American College of Physicians (ACP).
Medical Economics
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Letter: Identification of high risk labours.
Journal: BMJ (1975)

that on the figures given "the acute myo- ca,rdial inifarction mortality appeared to be twice as high in the beta-blocked patients as in the control group."The further infomiation swplied by Dr. Oram and his colleagues on the two-year survival of 35 of the trial patients on tolamolol is encouraging but irrelevant to the present argument as they are a preselected group.
PSYCHIC DRIVING
Authors: D. EWEN CAMERON
Journal: American Journal of Psychiatry (1956)

1. Psychic driving is a potent procedure/p=m-/it invariably produces responses in the patient, and often intense responses. 2. The responses tend ultimately to be therapeutic. 3. To account for the effects of psychic driving the following working hypotheses have been set up: a. Penetration of shielding.—Defenses of the individual against the full implications of his verbal communications are circumvented by using air conduction only, rather than the synthesis of air and tissue conduction to deal with which his defenses were organized. b. Driving./p=m-/Constant repetition of the verbal cue locks the patient into continual response in terms of the community of action tendencies of which the cue is part. c. Talking and Listening.—Working ideas concerning these and their bearing on the penetrating effect of driving have been set forth. d. Dynamic Implant.—A given period of psychic driving may continue to produce additional effects after the period of actual driving has been terminated. To account for this, a premise has been advanced that a period of psychic driving may set up within the individual an area of intensified responsiveness, which calls him back repeatedly into activation of the area concerned. 4. Psychic driving lends itself to a great many modifications with respect to its application. These have been listed, and include autopsychic and heteropsychic driving, variations in the mechanical procedures and variations in the preparation of the patient for psychic driving. It is still too early to determine the various particular values of these; the material presented has been derived primarily from short-term autopsychic driving without adjuvants.
TREPHINING FOR CEREBRAL HEMORRHAGE.
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Regulatory and legal influences on physicians' office laboratories
Authors: R. F. Wildermann
Journal: JAMA (1986)

We believe that the current shift of analysis from hospital and independent laboratories to physicians' offices will continue. As the volume of laboratory work performed in physicians' offices increases, there will be increased pressure at the federal and state levels to regulate these laboratories. The purpose of such regulation will be to ensure adequate quality and fair competition. These office laboratories will also be at an increased risk for malpractice claims. If they can offer high-quality analysis in a cost-effective manner, physicians will continue, in the long run, to expand their office analytic services. (<i>JAMA</i>1986;256:252-253)
Characterization of Various Classes of Protein Adducts
Authors: Steven R. Tannenbaum, Paul L. Skipper, John S. Wishnok, W. G. Stillwell, Billy W. Day, Koli Taghizadeh
Journal: Environmental Health Perspectives (1993)

Analysis of the types of protein adducts formed by chemical carcinogens indicate that adducts may be categorized into various classes according to the nature of the carcinogen as well as the amino acid with which they react. Tryptophan(214) of serum albumin was previously shown to react specifically with N-sulfonyloxy-N-acetyl-4-aminobiphenyl. The same residue is now shown to also react with the sulfate esters of N-hydroxy-N-acetyl-2-aminofluorene and N-hydroxy-N,N'-diacetylbenzidine. Thus, Trp-214 appears to be a binding site for a variety of activated N-aryl hydroxamic acids. Epoxides and diol epoxides derived from polynuclear aromatic hydrocarbons alkylate carboxylic groups in hemoglobin and serum albumin. Because the esters formed are readily hydrolyzed to dihydrodiols and tetrahydrotetrols which can be determined by GC-MS, it is possible to analyze for a wide range of polyaromatic hydrocarbon (PAH) epoxide adducts. With this approach it was shown that human subjects experiencing exposure to ambient levels of environmental PAH do take up and metabolize chrysene and benzo[a]pyrene. Feral, bottom-dwelling fish inhabiting contaminated waters were also examined. Globin adducts containing certain dihydroxy groups such as those arising in anti-diol epoxide adducts were concentrated by boronate affinity chromatography and further analyzed by HPLC with diode-array UV/visible detection. Four compounds were detected that exhibited spectra characteristic of a polynuclear chromophore. Two of these appeared to be isomers. Further instrumental analysis is needed to elucidate the structure of these unknown putative adducts.(ABSTRACT TRUNCATED AT 250 WORDS)
A moveable feast
Authors: Peter F. Dominey
Journal: Behavioral and Brain Sciences (2000)

Neural organization achieves its stated goal to “show how theory and experiment can supplement each other in an integrated, evolving account of structure, function, and dynamics” (p. ix), showing in a variety of contexts – from olfactory processing to spatial navigation, motor learning and more – how function may be realized in the neural tissue, with explanatory and predictive neural network models providing a cornerstone in this approach.
Asthma—United States, 1980-1990
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Infective Endocarditis in the Antibiotic Era
Authors: Phillip I. Lerner, Louis Weinstein
Journal: New England Journal of Medicine (1966)

Underlying Heart DiseaseThe incidence of various types of heart disease observed in the 100 patients studied at the New England Medical Center Hospitals is presented in Table 5. In 39 per cent no antecedent cardiac disorder could be discovered during life or on examination at autopsy.The inability to establish accurately the specific nature of the type of cardiac lesion underlying an episode of BE on clinical grounds alone is illustrated by 1 of our cases in which death finally permitted pathological definition of an unusual syndrome.J.D. (N.E.M.C.H. 152–602), a 77-year-old white woman, had had headache, anorexia, malaise, severe . . .
Infectious disease associations in indolent lymphoma (follicular, FL and non-follicular, nFL): Developing a lymphoma prevention strategy
Authors: C. S. Portlock, A. Noy, P. Hamlin, J. Qin, L. Rosenzweig, S. Corcoran, W. Chey, G. Papanicolaou, A. Markowitz
Journal: Journal of Clinical Oncology (2004)

6701 Background: The antigen-drive association of gastric MALT lymphoma with H. pylori is well recognized. Successful antibiotic therapy can result in lymphoma remission, and with it, lymphoma prevention. We have sought to prospectively identify possible associated infections (candidates for antigen-drive) in patients with non-bulky, advanced stage indolent lymphoma as the first step to such a lymphoma treatment/ prevention strategy. These patients are often given a recommendation of monitoring ("watch and wait") and it is during this period that a window of opportunity may exist to identify and treat antigen-drive related infections. Methods: Patients with a new diagnosis of indolent lymphoma (FL and nFL), stages II (intra-abdominal), III and IV fulfilling GELF criteria for observation were eligible. Studies performed: Stool H. pylori, Hepatitis C and Borrelia serologies, Borrelia and Chlamydia fixed tissue PCR, peripheral blood mononuclear cell PCR for Chlamydia, and a hydrogen breath test for small bowel bacterial overgrowth. Results: To date 13 patients have been enrolled with IRB informed consent: 9 females, 4 males; median age, 51 years (34–70); 7 FL, 6 nFL; stage II (1 pt), III (3), and IV (9). All met GELF criteria for observation. Infections tested thus far include: H. pylori (3 positive, nFL); Hepatitis C (2+; 1FL, 1nFL); and small bowel bacterial overgrowth (3+; 1FL, 2nFL). Borrelia serologies were negative in all 13 pts. PCR for Borrelia and Chlamydia are pending. Thus, 7 of 13 patients have at least one positive study. These infections have been/are being treated and clinical outcomes of lymphoma will be assessed. Conclusions: Infections are common in advanced stage indolent lymphoma (54% to date in our series). The identification of antigen-drive associated infections may be a first step toward developing a lymphoma prevention strategy. No significant financial relationships to disclose.
Involvement of calcium in macrophage leukotriene release during experimental cirrhosis
Authors: L ALRIC
Journal: Hepatology (1996)

The aim of the present study was to assess the mechanism of 5-lipoxygenase metabolites (LT) secretion by peritoneal macrophages in rats wih CC14 induced cirrhosis. After stimulation with calcium ionophore A23187 or opsonized zymosan, [3H] arachidonic acid labeled macrophages from cirrhotic rats presented a significantly greater secretion of LT than macrophages from healthy controls. In addition, the phorbol ester TPA (protein kinase C activator) increased LT production only in macrophages from cirrhotic animals and not in controls. Although Ca2+ is thought to be involved in 5 lipoxygenase activation, the role of Ca2+ in LT production was studied. The use of a Ca2+-free medium as well as the addition of TMB-8 (an inhibitor of intra-cellular Ca2+ movements and of plasma membrane Ca2+ fluxes) resulted in a fall in LT production greater for macrophages from cirrhotic animals than for controls. The measurement of cytosolic Ca2+ concentration by cytofluorimetry showed that Fluo-3 loaded macrophages from cirrhotic rats had a greater cytosolic CA2+ concentration than macrophages from control animals both in basal conditions and after A23187 stimulation. Study of 45Ca2+ uptake suggest, that extra-cellular Ca2+ is implicated in the elevated cytosolic Ca2+ observed in macrophages from cirrhotic animals as compared to healthy controls. The greater Ca2+ concentration observed in macrophages from cirrhotic rats was not related to a difference in phospholipase C activation because inositol phosphate production did not differ between macrophages from healthy and cirrhotic animals. Taken together these results suggest that as compared to healthy animals, the greater LT production during cirrhosis could be dependent upon a difference in 5-lipoxygenase activation related to a rise in cytosolic Ca2+ concentration independently of inositol phosphates generation.
THE STATE OF THE BLOOD ASSOCIATED WITH ADRENAL DISEASE.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tolerance to the anti-seborrhoeic effect of topically applied progesterone
Authors: N.B. Simpson, P.E. Bowden, W.J. Cunliffe, R.A. Forster
Journal: British Journal of Dermatology (1978)

Journal Article Tolerance to the anti‐seborrhoeic effect of topically applied progesterone Get access N.B. Simpson, N.B. Simpson Department of Dermatology, The General Infirmary, Leeds Search for other works by this author on: Oxford Academic Google Scholar P.E. Bowden, P.E. Bowden Department of Dermatology, The General Infirmary, Leeds Search for other works by this author on: Oxford Academic Google Scholar W.J. Cunliffe, W.J. Cunliffe Department of Dermatology, The General Infirmary, Leeds Search for other works by this author on: Oxford Academic Google Scholar R.A. Forster R.A. Forster Department of Dermatology, The General Infirmary, Leeds Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 98, Issue s16, 1 July 1978, Page 9, https://doi.org/10.1111/j.1365-2133.1978.tb13580.x Published: 01 July 1978
Heat Stroke
Authors: George H. A. Clowes, Thomas F. O'Donnell
Journal: New England Journal of Medicine (1974)

HEAT stroke is an acute medical emergency. The unconscious hyperpyretic patient (rectal temperature of 41 to 43°C) is in grave danger of death. Mortality rates ranging from 17 to 70 per cent are reported.1 2 3 Heat stroke is caused by excessive heat storage when high ambient temperature prevents heat dissipation by radiation or convection and sweat evaporation is limited by humidity. Not only does prompt recognition and treatment by immediate cooling and supportive measures greatly reduce the previously reported high mortality,4 5 but understanding of the cause makes the catastrophe of heat stroke, in great measure, preventable.6 , 7 Body-Temperature Regulation and Factors Inducing . . .