tbuckley/cabot-search huggingface dataset:
Dr Takemi and the atomic bomb. A footnote to history
Authors: D. T. Cloud
Journal: JAMA (1995)

WHEN the United States dropped the atomic bomb on Hiroshima 50 years ago, a young Japanese physician named Tarô Takemi, within hours, correctly analyzed the nature of the holocaust, then risked his life in a brazen effort to win time for the Japanese military leaders to come to their senses and surrender. Nearly four decades after the bombing of Hiroshima, Takemi treated me to a personal account of his remarkable venture. It was a riveting tale of courage and legerdemain, and hearing it first hand from Takemi was a moving experience. Equally moving was the haunting Takemi memoir, wherein he reported the story in greater detail, though characteristically understated, published in<i>JAMA</i>only months before his death.<sup>1</sup> When I first met Takemi, in 1979, I was somewhat taken aback. "This guy is right out of central casting," I thought. He was short and bandy-legged with a balding bullethead, furrowed
Cost-effectiveness of scaling-up treatment with nucleoside analogue (NA) for chronic HBV infection: Towards a simplification of recommendations? (ANRS study)
Authors: Clotilde Lepers, Helene Fontaine, Fabrice Carrat, Philippe Mathurin, Stanislas Pol, Fabien Zoulim, Yazdan Yazdanpanah, Sylvie Deuffic-Burban
Journal: Journal of Hepatology (2020)
In Parting
Authors: J.R. E.
Journal: Annals of Internal Medicine (1971)

Editorials1 June 1971In PartingJ.R. E.J.R. E.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-74-6-1001 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe arthurian dictum, "the old order changeth yielding place to new," applies to editorships as well as to most other activities of life. This issue of the ANNALS will be the last to be published under the name of the present Editor who, for reasons of personal health, is retiring from the Editorship at the end of this month. I take this step with regret, yet with gratitude for the opportunity to have served my profession in this way.When in September 1959 Dr. Chester M. Jones, on behalf of the American College of Physicians, asked me if I would... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byJ. Russell Elkinton, M.D., M.A.C.P.: A TributeMARSHALL N. FULTON, M.D. 1 June 1971Volume 74, Issue 6Page: 1001-1002KeywordsEmotionsGratitude ePublished: 1 December 2008 Issue Published: 1 June 1971 PDF downloadLoading ...
Daily Variation of Particulate Air Pollution and Poor Cardiac Autonomic Control in the Elderly
Authors: Duanping Liao, John Creason, Carl Shy, Ron Williams, Randall Watts, Roy Zweidinger
Journal: Environmental Health Perspectives (1999)

examined the cardiac autonomic response to daily variations in PM in 26 elderly (mean age 81) individuals for 3 consecutive weeks. Several standardized methods were used to measure 24-hr average PM concentrations prior to the clinical test inside (indoor PM2.5) and immediately outside (outdoor PM2.5 and PM2.5-10) of participants' residences. Resting, supine, 6-min R wave to R wave (R-R) interval data were collected to estimate high frequency (0.15-0.40 Hz) and low frequency (0.04-0.15 Hz) powers and standard deviation of normal R-R intervals (SDNN) as cardiac autonomic control indices. Participant-specific lower heart rate variability days were defined as days for which the high-frequency indices fell below the first tertile of the individual's high-frequency distribution over the study period. Indoor PM2.5 > 15 microg/m3 was used to define high pollution days. Results show that the odds ratio (95% confidence interval) of low heart rate variability high frequency for high (vs. not high) pollution days was 3.08 (1.43, 6.59). The ss-coefficients (standard error) from mixed models to assess the quantitative relationship between variations in indoor PM2.5 and the log-transformed high frequency, low frequency, and SDNN were: -0.029 (0.010), -0.027 (0.009), and -0.004 (0.003), respectively. This first study of cardiac autonomic control response to daily variations of PM2.5 indicates that increased levels of PM2.5 are associated with lower cardiac autonomic control, suggesting a possible mechanistic link between PM and cardiovascular disease mortality.
NIH Consensus conference. Optimal calcium intake. NIH Consensus Development Panel on Optimal Calcium Intake
Authors: John P. Bilezikian, Lynn Bailey, Patricia J. Elmer, Murray J. Favus, Vay Liang W. Go, Steven R. Goldring, Linda Hughey Holt, Karl L. Insogna, Barbara Krimgold, Lawrence E. Mallette, Jay R. Shapiro, Sachiko T. St. Jeor, Paula H. Stern, Barbara C. Tilley, Monica E. Yamamoto, Steven A. Abrams, Alberto Ascherio, John A. Baron, Norman H. Bell, Elizabeth A. Chrischilles, Bess Dawson-Hughes, Robert P. Heaney, Michael F. Holick, C. Conrad Johnston, Michael Kleerekoper, Jacob Lemann, Richard J. Levine, Robert Lindsay, Anne C. Looker, Betsy C. Love, Robert Marcus, Velimir Matkovic, L. Joseph Melton, Pierre J. Meunier, Juan M. Navia, Dorothy A. Nelson, Eric S. Orwoll, William A. Peck, Robert R. Recker, Lawrence M. Resnick, B. Lawrence Riggs, Frederick R. Singer, Charles W. Slemenda, MaryFran R. Sowers, Connie M. Weaver, Sanford A. Miller, Walter C. Willett, Lawrence E. Shulman, Elia Ben-Ari, Elsa Bray, Mona S. Calvo, Nancy D. Ernst, John H. Ferguson, Gilman D. Grave, John G. Haddad, William H. Hall, Stephen P. Heyse, Van S. Hubbard, Joan A. McGowan, Marjorie Perloff, Ellyn J. Pollack, Maryann Reford, Pamela E. Stark-Reed
Journal: JAMA (1994)

IT HAS BEEN a decade since the 1984 Consensus Development Conference on Osteoporosis first suggested that increased intake of calcium might help prevent osteoporosis. Osteoporosis affects more than 25 million people in the United States and is the major underlying cause of bone fractures in postmenopausal women and the elderly. Previous surveys have revealed that the US population experiences more than 1.5 million fractures annually at a cost in excess of $10 billion per year to the health care system. Two important factors that influence the occurrence of osteoporosis are optimal peak bone mass attained in the first two to three decades of life and the rate at which bone is lost in later years. Adequate calcium intake is critical to achieving optimal peak bone mass and modifies the rate of bone loss associated with aging. A number of publications have addressed the possible role of calcium intake in the
Adding Topotecan to Standard Treatment for Ovarian Cancer Does Not Improve Progression-Free Survival
Journal: JNCI Journal of the National Cancer Institute (2010)

Adding Topotecan to Standard Treatment for Ovarian Cancer Does Not Improve Progression-Free SurvivalAdding topotecan to carboplatin plus paclitaxel, the standard treatment for ovarian cancer, does not improve progression-free survival in patients and leads to greater toxicity, according to a study published online October 11 in The Journal of the National Cancer Institute.Cisplatin plus paclitaxel, and carboplatin plus paclitaxel, are the most widely accepted first-line regimens for advanced epithelial ovarian cancer.Still, most women relapse and die from their disease.One possible solution that has been tried is to add a third agent, such as topotecan, which has activity in the treatment of recurrent disease.However, combining topotecan with carboplatin plus paclitaxel as a triplet therapy is problematic because of bone marrow toxicity.So, to integrate topotecan into the standard regimen researchers tested cisplatin plus topotecan followed by carboplatin plus paclitaxel.
INSANE SELECTION OF INSANE HOSPITAL SITES.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
NORTH/HGCSG1003: A phase II study evaluating the safety and efficacy of FOLFOX as adjuvant chemotherapy for patients with stage III colon cancer: Comparison with medical oncologists and surgeons
Authors: S. Yuki, Y. Komatsu, Y. Kawamoto, H. Nakatsumi, N. Takahashi, T. Shichinohe, H. Okuda, A. Ishiguro, K. Harada, I. Iwanaga, K. Hatanaka, K. Oomori, M. Nakamura, N. Senmaru, K. Iwai, M. Koike, T. Shinohara, K. Miyashita, Y.M. Ito, A. Taketomi, S. Hirano, N. Sakamoto
Journal: Annals of Oncology (2018)

Introduction: The efficacy of oxaliplatin containing regimens were confirmed in large randomized phase III trials in which they were superior to fluorouracil and leucovorin as adjuvant setting for patients with stage III colon cancer. In Japan, not only medical oncologists but also surgeons practice chemotherapy. In this analysis, we investigated differences in safety and efficacy between surgeons and medical oncologists from NORTH/HGCSG1003 study. Methods: NORTH/HGCSG1003 is a multicenter phase II study. This study enrolled patients with resected stage III colon cancer. Patients received FOLFOX4 or mFOLFOX6 repeated every 2 weeks for 12 cycles. Primary endpoint is disease-free survival, and secondary endpoints were overall survival, safety, RDI and so on. In this analysis, pts characteristics and safety were compared using Fisher's exact test. Dose intensity was compared using Student's t-test, and DFS and RFS using log-rank test. Results: From September 2010 to March 2013, 273 patients at 28 institutions were enrolled. In the eligible population (n = 264), 159 patients were treated with chemotherapy by medical oncologists (group O) and 105 patients by surgeons (group S). Patients' characteristics between two groups were well balanced except for bowel obstruction before surgery (8.8% in group O vs 23.8% in group S; p = 0.001). Median RDI (group O vs group S) of oxaliplatin was 0.631 vs 0.751 (p Conclusion: RDI of oxaliplatin and bolus 5-FU were significantly lower in group O than group S. The frequency of platelet count decreased (all grade) was significantly less in O. This was presumed to be because the relative dose intensity of oxaliplatin was significantly lower in O. However, there was no significant difference in the frequency of peripheral sensory neuropathy. There was no significant difference in efficacy between O and S.
Bryan Lask
Authors: Janet Fricker
Journal: BMJ (2016)

This is a case of a previously healthy 51-year-old man who sustained bilateral central hip dislocations following a sudden presentation of epileptic seizures. The patient was initially treated conservatively for a period of 9 months. On presentation, he had gross disability due to stiffness in both hips and left peroneal nerve paresis. Through minimally invasive direct anterior approaches, bilateral total hip arthroplasties were performed using tripolar head articulations. These were cemented into a biologic acetabular buttress constructed out of autologous bone graft. The femoral heads and necks were used as plugs and pressed into the acetabular defects, putting the medial acetabular walls under tension. At 24 months’ follow-up, there was a good clinical outcome, and the acetabular walls remodelled bilaterally. In conclusion, in traumatic protrusio acetabuli, a functional, biologic reconstruction of the acetabular wall can be facilitated with the application of distraction osteogenesis (tension-stress) principles while using minimally invasive surgical techniques.
Ueber die Entwicklung und den Ausbau der Suprasymphysären Schnittentbindung an der Universitäts-Frauenklinik Tübingen.
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 2053: Targeting GRK2 increases chemotherapy-induced apoptosis in medulloblastoma
Authors: Anup S. Pathania, Xiuhai Ren, Min Mahdi, Gregory M. Shackleford, Anat Erdreich-Epstein
Journal: Cancer Research (2019)

Abstract Background: G protein receptor kinase-2 (GRK2; ADRBK1) belongs to the family of G protein-coupled receptor (GPCR) kinases (GRKs). GRK2 phosphorylates GPCR and non-GPCR targets including cell surface receptors, cytoskeletal and mitochondrial proteins and transcription factors. It also functions in embryonic development, heart function, metabolism, and some cancer models. Here we hypothesized that targeting GRK2 will sensitizes cancer cells to therapy. We tested this in medulloblastoma, the most common malignant brain tumor in children. Methods: siRNA transfections, shRNA viral infections, SDS-PAGE, western blotting, flow cytometry. Cells: UW228 and DAOY medulloblastoma. Results: We found that GRK2 inhibition promotes anti-tumor effects of chemotherapeutic drugs cisplatin and etoposide in UW228 and DAOY medulloblastoma cell lines. GRK2 silencing increased apoptosis induced by cisplatin and etoposide and GRK2 overexpression decreased apoptosis induced by these drugs in UW228 and DAOY. Time dependent studies revealed that GRK2 overexpression delayed cisplatin- and etoposide-induced apoptosis measured by the induction of Annexin V positive population and by PARP-1 cleavage. GRK2 mutants, GRK2 K220R (kinase deficient mutant) and GRK2 S670A (cannot be phosphorylated) were similar to wildtype GRK2 in delaying the cisplatin and etoposide induced apoptosis. GRK2 knockdown antagonized serum induced AKT and ERK phosphorylation in both lines whereas GRK2 overexpression promoted phosphorylation, suggesting that GRK2 is important in medulloblastoma survival pathways. Conclusions: These results demonstrate that targeting GRK2 enhances cisplatin- and etoposide-induced apoptosis in medulloblastoma cell lines and suggests that GRK2 inhibitors may enhance responsiveness of medulloblastoma to chemotherapy. Citation Format: Anup S. Pathania, Xiuhai Ren, Min Mahdi, Gregory M. Shackleford, Anat Erdreich-Epstein. Targeting GRK2 increases chemotherapy-induced apoptosis in medulloblastoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2053.
Helmets and Preventing Motorcycle and Bicycle Injuries: Comments and a Correction
Authors: Michael P. Resnick
Journal: JAMA (1995)

<h3>To the Editor.</h3> —We read with interest the Council Report entitled "Helmets and Preventing Motorcycle- and Bicycle- Related Injuries."1 We agree that promoting the wearing of helmets by bicyclists is desirable. Oregon recently passed such a law requiring bicyclists younger than 16 years to wear helmets. Liability insurance covering most organized riding requires the use of approved helmets by adults. However, none of these laws or events address how well helmets fit. We were participants and/or provided medical backup to Cycle Oregon, a 500-mile tour for adults. This multiday tour of 2000 cyclists has 7 years' experience without a serious head injury. Some of the reasons for this safety record are the choice of low-trafficked, well-surfaced roads and the emphasis on rider responsibility and safety. Cycle Oregon publishes a daily newspaper, the<i>Cycle Oregonian</i>. Early in the tour, it published guidelines on the appropriate fitting of helmets. Three days after
Diet and Dental Health
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Readmission rates
Authors: J. P. Drozda
Journal: BMJ (2013)

Allocation decisions in emergency medicine must occur when demand for emergency services exceeds supply. In many circumstances, strong clinical or cost evidence upon which to base allocation decisions is lacking. In these circumstances, patient or community preference may be used to inform decisions. If preference is to be incorporated into allocation decision-making, scientifically rigorous quantitative methods should be chosen for measuring preference. This article describes the theoretical background, advantages, risks and applications of discrete choice experiments for measuring patient preference in emergency medicine.
Diabetic ketoacidosis in prisoners without access to insulin
Authors: A. S. Keller
Journal: JAMA (1993)

<h3>Objective.</h3> —To assess the cause and clinical severity of diabetic ketoacidosis in male prisoners hospitalized in New York City. <h3>Design.</h3> —Retrospective chart review. <h3>Setting.</h3> —A municipal hospital in New York City. <h3>Patients.</h3> —Forty-nine adult male prisoners with a total of 54 hospital admissions for diabetic ketoacidosis between January 1, 1989, and June 30, 1991. <h3>Main Outcome Measures.</h3> —Charts were reviewed for diabetic and medical history, time from arrest until hospitalization, cause of diabetic ketoacidosis, admission laboratory data, and hospital course. <h3>Results.</h3> —Thirty-eight (70%) of the 54 admissions for diabetic ketoacidosis among prisoners occurred because prisoners had not received insulin during the period immediately following arrest (mean number of days from arrest until hospitalization was 2.5). All of these individuals had a history of insulin-dependent diabetes and were reportedly compliant with their insulin regimen at the time of arrest. Admission laboratory data for this group of prisoners included a mean serum glucose level of 27.4 mmol/L (495 mg/dL) and a mean serum bicarbonate level of 14.4 mmol/L. Mean number of days in the hospital was 3.4 including a mean of 1 day in an intensive care unit. <h3>Conclusions.</h3> —Inadequate access to medication results in serious sequelae for recently arrested prisoners in New York City with insulin-dependent diabetes. Access to health care for recently arrested prisoners needs to be improved. (<i>JAMA</i>. 1993;269:619-621)
An Exploratory Study, Drugs and Social Interaction
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal