tbuckley/cabot-search huggingface dataset:
Preoperative Prediction of Postoperative Delirium
Authors: Dorene A. O'Hara
Journal: JAMA (1994)

<h3>To the Editor.</h3> —We have read with interest the article by Marcantonio et al.<sup>1</sup>It was surprising not to see any contribution by anesthesiologists to the protocol, as the anesthetic and postoperative pain regimens should significantly affect the incidence of delirium. Although this study attempted to find a preoperative predictive scale, failure to control for the anesthetic technique and intraoperative events admits a bias that might affect, if not negate, the results. Different anesthesiologists may administer drugs that produce frank delirium under some circumstances. Drugs such as droperidol or benzodiazepines, especially in the elderly, can cause confusion. Whether or not a regional anesthetic with or without sedation was administered would also be important. For example, it has been demonstrated that the incidence of thromboembolic events (including stroke) decreases with epidural anesthesia for vascular surgery.<sup>2</sup> These data should have been collected, and possibly controlled for, in this prospective study.
Why does uremia in heroin abusers occur predominantly among blacks?
Authors: E. A. Friedman
Journal: JAMA (1983)

Racial differences in the incidence and cause of renal failure have been reported in South Africa, where analgesic nephropathy is preponderantly a disease of whites and hypertensive kidney damage is observed mainly in blacks.<sup>1</sup>In the United States, analysis of expenditures by the federal end-stage renal disease (ESRD) program bears out the clinical impression held by urban nephrologists that renal failure is more prevalent in blacks than in whites. Of 61,184 patients entered into federally funded dialysis programs between July 1973 and March 1982, the proportion of blacks was 28.1%, which far exceeded their representation of 11% in the total population.<sup>2</sup> Sickle cell hemoglobinopathy causing renal papillary necrosis and hematuria in carriers of the trait and membranoproliferative glomerulonephritis, sometimes progressing to uremia, in those with sickle cell disease affords a clear example of a nephropathy transmitted genetically in blacks.<sup>3</sup>Hypertensive cardiorenal syndromes and strokes are common in
Clinical Pharmacol &amp; Therapeutics, St. Louis
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dipyridamole-thallium scanning in patients undergoing vascular surgery
Journal: JAMA (1987)

<h3>To the Editor.—</h3> With regard to the article entitled "Dipyridamole-Thallium Scanning in Patients Undergoing Vascular Surgery" by Eagle et al,<sup>1</sup>a few comments are offered. It is unclear what is the value of the authors' validation set. Although this validation was done prospectively, it did not add any further information. In addition, the patients' surgical procedures were different in the two groups. The incidence of significant coronary disease in asymptomatic candidates for abdominal aortic surgery is known to be higher than for carotid or distal ischemic extremity surgery.<sup>2</sup>A true validation set, if necessary, would have just consisted of patients due for abdominal aortic reconstructive surgery. The study looked at outcome but treated anesthesia and surgery as a constant. Previous studies have documented that choice of anesthesia and the anesthesiologist may make a significant difference in the outcome of high-risk cardiac procedures.<sup>3,4</sup>These variables were not assessed.
FAT AND SLEEK WITH GOOD KEEPING A HOG OF EPICURUS' HERD
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Intramuscular Injection of Trypsin: Its Value as a Thrombolytic and Anti-Inflammatory Agent
Authors: Kenneth M. Moser
Journal: New England Journal of Medicine (1957)

ENZYMES, once regarded by most physicians as the mysterious and complex playthings of the biochemist, have steadily climbed to a position of eminence and familiarity in many fields of medicine. The ever-increasing importance of these substances has sprung from the realization that enzymatic processes supply the basic electricity that runs the human machine.Although the diagnostic and experimental applications of enzymes have already gained medical sanction, the therapeutic use of these agents has lagged behind. Recent developments, however, suggest that enzymatic therapy may shortly assume a position of consequence.Many enzymes are currently in medical use.1 This paper, however, deals . . .
Internal Rhythm
Authors: Erik Norbie
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The relationship of house staff experience to the cost and quality of inpatient care
Authors: E. C. Rich
Journal: JAMA (1990)

The inexperience of house staff has been offered as one explanation for the increased cost of care at teaching hospitals, but conclusive evidence for this has been lacking. We studied the relationship of house staff experience to the cost and quality of inpatient care in a large series of internal medicine patients at one teaching hospital. We defined house staff experience by the month of academic year during which the patient received care. Our measures of cost were length of hospital stay and total hospital charges, while our measures of quality were hospital deaths, hospital readmissions, and nursing home placement. Multiple linear regression analysis on 21 679 hospital discharges revealed increasing house staff experience to be associated with a significant decline in length of stay (95% confidence interval for b, — 0.006 to — 0.066 days per discharge per month of house staff experience) and total hospital charges (95% confidence interval for b, — 0.002 to — 0.017 log dollars per discharge per month of house staff experience). These findings constitute an estimated average decline of 0.43 days per discharge and $370 per discharge over the academic year. Logistic regression analysis found no relationship of house staff experience to hospital deaths, readmissions, or nursing home placement. These findings suggest that the process of training inexperienced physicians may represent an important source of inefficiency for teaching hospitals struggling in a competitive environment. (<i>JAMA</i>. 1990;263:953-957)
Abstract 1392: Increased High Density Lipoprotein Cholesterol induced by Human Apolipoprotein A-I Gene Transfer increases Adiponectin Expression in abdominal Adipose Tissue
Authors: Sophie Van Linthout, Frank Spillmann, Anna Foryst-Ludwig, Carola Bücker-Gärtner, Marco Meloni, Yingmei Feng, Ulrich Kintscher, Bart De Geest, Heinz-Peter Schultheiss, Carsten Tschoepe
Journal: Circulation (2007)

Introduction: High density lipoprotein (HDL) cholesterol (C) levels positively correlate with plasma adiponectin levels. However, the role of HDL on adiponectin expression is unkown. To investigate the effect of increased HDL levels on adiponectin expression, 1) gene transfer with human apolipoprotein (apo) A-I, the main apo of HDL, was performed in control mice and in lipopolysaccharide (LPS)-injected mice, associated with decreased adiponectin levels and 2) HDL was supplemented in vitro on (pre)-adipocytes. Methods: Eight weeks old male C57BL/6 mice were i.v. injected with 5 × 10e10 total particles of the E1E3E4-deleted adenoviral vector Ad.hapoA-I, expressing human apo A-I or with the same dose of Ad.Null, containing no expression cassette. Fourteen days hereafter, mice were i.p. injected with LPS from Escherichia coli at a dose of 80 mg/kg or with saline. Mice were sacrificed 12 hours after LPS or saline injection. Human apo A-I and mouse adiponectin plasma concentrations were determined by ELISA. Abdominal fat phospho (p) and total (tot.) Akt protein levels were determined by Western Blot; adiponectin mRNA expression of (pre)-adipocytes by real-time PCR. Results: Ad.hapoA-I GT resulted in human apo A-I expression levels of 83Â27&gt;4.6 mg/dl at day 14, which was associated with 1.8-fold (p&lt;0.05) and 1.5-fold (p&lt;0.05) higher HDL-C and adiponectin levels compared to Ad.Null mice, respectively. After LPS-injection, human apo A-I levels decreased by 1.7-fold (p&lt;0.001), leading to 1.7-fold lower adiponectin levels compared to Ad.hapoA-I control mice, but still 1.5-fold (p&lt;0.01) higher compared to LPS-Ad.Null mice. The increased adiponectin levels in Ad.hapoA-I versus Ad.Null LPS-injected mice were associated with a 1.7-fold (p&lt;0.05) increase in p-Akt/tot.Akt ratio. In vitro, LPS administration decreased adiponectin expression by 2.1-fold (p&lt;0.01), which was normalized to control levels by HDL supplementation in a phosphatidylinositol-3-kinase (PI3K)-dependent manner, since Ly 294002 reversed the HDL-mediated increase in adiponectin expression. Conclusion: HDL increases adiponectin expression via the PI3K-Akt pathway, which may contribute to some of the pleiotropic actions of HDL such as its well-known anti-inflammatory effects.
Tabulæ Anatomicæ Osteologiæ. Edited a Carolo H. von Klein.
Journal: JAMA (1883)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Transactions of the Minnesota State Medical Society, 1883.
Journal: JAMA (1884)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abdominal Surgery
Authors: H. H. Bradshaw
Journal: JAMA (1961)

This is a satisfying book to read. It consists of 22 chapters, each written by 1 to 3 well-known surgeons from university hospitals or large private clinics. The material, therefore, represents the thinking and practice of men of extensive experience and is authoritative. The contributors have obviously been selected because of their fields of special interest and proved ability. They represent many institutions and wide geographical distribution, which eliminates a provincial point of view. The text covers abdominal surgery in a thorough manner from the anatomy of incisions to diseases of the anus. Each chapter has a pertinent list of references that is not so extensive as to bewilder the student. The subject matter is dealt with in a clear, concise manner, and verbosity is practically eliminated. The illustrations and the reproductions of roentgenograms are easily understandable and are of recent origin, in the main. Each topic is discussed according
ANNUAL ADDRESS
Authors: John L. Atlee
Journal: JAMA (1883)

Gentlemen of the American Medical Association: Permit me to express my feelings of gratitude for the unexpected honor conferred upon me at the last meeting of the Association, and to cherish the hope that in fulfilling the duties of this responsible position I may be sustained by your cordial co-operation. We meet here to engage earnestly in furthering the interests and objects of the medical profession. We have come together from all parts of our broad country, charged with these great responsibilities. It is fitting to express here deep regret at the absence from our councils of delegates from the Medical Society of the State of New York. Let us hope that this absence may be only temporary, and that at the next meeting every State may be represented. As specialties are so much in favor at the present time, I have thought it well, though far from favoring them
Athletic facial injuries
Authors: R. C. Schultz
Journal: JAMA (1984)

Most facial injuries that occur during athletic activities are of a minor nature, consisting of lacerations, contusions, and abrasions. These are usually treated by a team physician or an emergency department physician. However, minor injuries must be differentiated from the more significant injuries, especially those involving facial bone fractures. Significant facial trauma must be diagnosed accurately and treated with precision to avoid permanent facial deformity. Soft-tissue trauma as well as fractures are included in this review, and evaluation of the injured athlete is emphasized. A systematic approach is developed for diagnosing and treating common facial injuries in athletes. (<i>JAMA</i>1984;252:3395-3398)
Errors in Affiliations.
Journal: JAMA (1995)

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Hepatology highlights
Authors: Neil Kaplowitz
Journal: Hepatology (2002)

After RON Is GoneThe RON receptor is a heterodimeric tyrosine kinase found in macrophages and Kupffer cells.Deletion of the tyrosine kinase domaine (Ron TK Ϫ/Ϫ ) of this gene is known to increase mortality in response to high dose endotoxin, suggesting a protective role for this receptor against the biological effects of endotoxin.Leonis et al. have extended their studies on Ron TK Ϫ/Ϫ mice using the galactosamine/low dose endotoxin model of liver injury.Surprisingly, these mice were protected and exhibited marked decreased hemorrhage and apoptosis by Tunel stain (see Fig. ), DNA laddering, and caspase 3. The Ron TK Ϫ/Ϫ mice exhibited an altered serum cytokine profile in response to endotoxin with enhanced TNF and decreased IL-10 and IFN-␦ levels.The Ron TK Ϫ/Ϫ mice were not protected against exogenous TNF plus galactosamine.Thus, protection by elimination of Ron signaling despite exaggerated TNF strongly supports the concept that the cytokine network and interplay of various cytokines rather than TNF alone determines the fate of the liver in response to endotoxin/galactosamine. (See
Coffee and plasma lipid levels
Authors: K. Kokjohn
Journal: JAMA (1992)

<h3>In Reply.</h3> —We thank Dr Kokjohn for her interest in our study and offer these answers to her questions. The 90th percentile of plasma total cholesterol levels for age was determined by the Lipid Research Clinics Prevalence Study.<sup>1</sup>Morbid obesity was defined as a body weight equal to or greater than 200% of ideal body weight for height, defined as the midpoint of the weight range for mediumframed men at given heights from Metropolitan Life Insurance Company tables of 1959.<sup>2</sup> All subjects assigned to drink coffee were asked to prepare their coffee using the same recipe, so that the treatment would remain consistent throughout the study for all subjects, and still permit enough additional coffee to be prepared for a spouse or other family member without the inconvenience of brewing two separate carafes of coffee. Data on compliance indicate that this did not lead to protocol violations. One
Government Extinguishes Marijuana Access, Advocates Smell Politics
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal