tbuckley/cabot-search huggingface dataset:
Acute Coronary Care in the Elderly, Part II
Authors: Karen P. Alexander, L. Kristin Newby, Paul W. Armstrong, Christopher P. Cannon, W. Brian Gibler, Michael W. Rich, Frans Van de Werf, Harvey D. White, W. Douglas Weaver, Mary D. Naylor, Joel M. Gore, Harlan M. Krumholz, E. Magnus Ohman
Journal: Circulation (2007)

Background— Age is an important determinant of outcomes for patients with acute coronary syndromes. However, community practice reveals a disproportionately lower use of cardiovascular medications and invasive treatment even among elderly patients who would stand to benefit. Limited trial data are available to guide care of older adults, which results in uncertainty about benefits and risks, particularly with newer medications or invasive treatments and in the setting of advanced age and complex health status. Methods and Results— Part II of this American Heart Association scientific statement summarizes evidence on presentation and treatment of ST-segment–elevation myocardial infarction in relation to age (&lt;65, 65 to 74, 75 to 84, and ≥85 years). The purpose of this statement is to identify areas in which the evidence is sufficient to guide practice in the elderly and to highlight areas that warrant further study. Treatment-related benefits should rise in an elderly population, yet data to confirm these benefits are limited, and the heterogeneity of older populations increases treatment-associated risks. Elderly patients with ST-segment–elevation myocardial infarction more often have relative and absolute contraindications to reperfusion, so eligibility for reperfusion declines with age, and yet elderly patients are less likely to receive reperfusion even if eligible. Data support a benefit from reperfusion in elderly subgroups up to age 85 years. The selection of reperfusion strategy is determined more by availability, time from presentation, shock, and comorbidity than by age. Additional data are needed on selection and dosing of adjunctive therapies and on complications in the elderly. A “one-size-fits-all” approach to care in the oldest old is not feasible, and ethical issues will remain even in the presence of adequate evidence. Nevertheless, if the contributors to treatment benefits and risks are understood, guideline-recommended care may be applied in a patient-centered manner in the oldest subset of patients. Conclusions— Few trials have adequately described treatment effects in older patients with ST-segment–elevation myocardial infarction. In the future, absolute and relative risks for efficacy and safety in age subgroups should be reported, and trials should make efforts to enroll the elderly in proportion to their prevalence among the treated population. Outcomes of particular relevance to the older adult, such as quality of life, physical function, and independence, should also be evaluated, and geriatric conditions unique to this age group, such as frailty and cognitive impairment, should be considered for their influence on care and outcomes. With these efforts, treatment risks can be minimized, and benefits can be placed within the health context of the elderly patient.
Anaphylactoid reaction to single-component pork insulin
Authors: R. A. Goldman
Journal: JAMA (1976)

A PATIENT who initially exhibited local skin erythema to single-component pork insulin went into anaphylaxis during single-component pork insulin desensitization. <h3>Case Report</h3> A 47-year-old woman with a five-month history of severe local erythema surrounding sites of insulin injection was admitted to Hahnemann Hospital for insulin desensitization. She did well in the hospital and for about two weeks after discharge with beef-pork isophane insulin suspension, but then, severe erythema and induration developed at the sites of insulin administration. A change to pork insulin zinc suspension (Lente) was no better. Skin tests employing beef- and pork-regular insulins, as well as pork insulin zinc suspension showed positive skin responses at the lowest insulin dilutions (0.001 units). Desensitization was attempted with single-component regular pork insulin according to the protocol shown in the Table. The patient had been supported with 10 units of pork insulin at six hourly intervals for 24 hours prior to the
Intravenous drug users and human immunodeficiency virus testing and counseling
Authors: Samuel Perry, Lawrence Jacobsberg, Pamela Weiler, Joanne Ryan, Karen Fogel
Journal: JAMA (1989)

<h3>To the Editor.—</h3> Curtis et al<sup>1</sup>recently reported inThe Journalthat 21% of intravenous (IV) drug users in their methadone maintenance program had, usually unbeknownst to staff, sought human immunodeficiency virus serological testing at other sites. The article raises the question whether, in the service of coordinating care, the testing site should share results with drug rehabilitation counselors. Based on our experience, we think not. We have two reasons First, IV drug users are unlikely to seek testing if they fear strict confidentiality will not be maintained.<sup>2</sup>For more than 2 years in our ongoing federally funded study of psychobehavioral responses to human immunodeficiency virus testing at The New York Hospital-Cornell Medical Center, we have extensively evaluated and followed up 49 IV drug users. Compared with the 315 subjects with other risk factors, the IV drug users have been at least as concerned about notification of third
Book Review Cardiac Arrhythmias: Clinical Features and Mechanism of the Irregular Heart . By Irving R. Roth, M.D. Introduction by Emanuel Libman, M.D. Large 8vo. (10 1/2 by 7 inches), extra cloth, 227 pages, 80 illustrations and five tables. Paul B. Hoeber, Inc., Publishers, New York, 1928.
Journal: New England Journal of Medicine (1928)
Marihuana and Society
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Generic Prescribing
Authors: Edward F. Skinner
Journal: JAMA (1966)

<h3>To the Editor:—</h3> The next time you attend a medical convention in any large city and are on your way from the airport to your hotel, raise your eyes above the street level. In second and third floor lofts you will see many small pharmaceutical companies in very dingy surroundings with obviously poor sanitary facilities. The pharmaceuticals manufactured in some of these loft factories are sometimes a combination of dust, ground-up cockroaches, and drug. Supervision by the local health department may be desultory and two years late. Almost every week we receive catalogs of cut-rate drugs from just such pharmaceutical companies. Pending legislation before the US Congress would make such generic prescribing mandatory. Such legislation is obviously not in the best interest of the patient. The physician should be allowed to prescribe drugs from a pharmaceutical house that he knows is ethical and holds to high sanitary standards, even though
Baseline self reported functional health and vulnerability to post-traumatic stress disorder after combat deployment: prospective US military cohort study
Journal: BMJ (2009)

Objective To determine if baseline functional health status, as measured by SF-36 (veterans), predicts new onset symptoms or diagnosis of post-traumatic stress disorder among deployed US military personnel with combat exposure.Design Prospective cohort analysis.Setting Millennium Cohort.Participants Combat deployed members who completed baseline (2001-3) and follow-up (2004-6) questionnaires.Self reported and electronic data used to examine the relation between functional health and posttraumatic stress disorder.Main outcome measures New onset post-traumatic stress disorder as measured by either meeting the DSM-IV criteria with the 17 item post-traumatic stress disorder checklist-civilian version or self report of a physician diagnosis at follow-up with the absence of both at baseline. ResultsOf the 5410 eligible participants, 395 (7.3%) had new onset symptoms or diagnosis of post-traumatic stress disorder at the time of follow-up.Individuals whose baseline mental or physical component summary scores were below the 15th centile had two to three times the risk of symptoms or a diagnosis of post-traumatic stress disorder by follow-up compared with those in the 15th to 85th centile.Of those with new onset symptoms or diagnosis of post-traumatic stress disorder, over half (58%) of cases occurred among participants with scores below the 15th centile at baseline.Conclusions Low mental or physical health status before combat exposure significantly increases the risk of symptoms or diagnosis of post-traumatic stress disorder after deployment.More vulnerable members of a population could be identified and benefit from interventions targeted to prevent new onset posttraumatic stress disorder.
Swine flu
Authors: R. Coker
Journal: BMJ (2009)

Fragile health systems will make surveillance and mitigation a challenge During March, Mexico saw unusual patterns of acute cases of respiratory infection.On 18 April, a laboratory in the United States reported two human cases of swine flu-the result of a novel reassortment of influenza A strain H1N1 from avian, swine, and human strains-in two children from California.A week later, on 25 April, the World Health Organization declared the swine flu outbreak in North America a "public health emergency of international concern."This decision, in accordance with the International Health Regulations, means that countries have been asked to step up reporting and surveillance of the deaths and illnesses associated with the disease.On 29 April, the International Health Regulations emergency committee recommended a change from WHO pandemic influenza phase 4 to phase 5.This means that WHO views a pandemic as imminent.From 17 April to 26 April, 1840 suspected cases of flu with severe pneumonia were reported in Mexico, 26 of which have been confirmed as swine flu.More than 150 people have died, and many have been in the 2040 year age range.As of 28 April, 64 human cases had been confirmed in the US (45 in New York, 10 in California, six in Texas, two in Kansas, and one in Ohio).The picture is highly fluid, but cases have also been confirmed in Canada, Spain, the United Kingdom, New Zealand, and Israel, and suspected cases have been reported in France, South Korea, and Brazil.No deaths have been reported outside Mexico, the reason for which is still unclear.New probable and confirmed cases are emerging daily.Given the widespread presence of the virus across many countries containment is probably not feasible, and efforts need to focus increasingly on mitigation.Interestingly, almost all cases reported so far have been reported by developed countries with robust surveillance systems.It is unclear whether this is because populations at risk have travelled preferentially from Mexico to those sites, or, more pessimistically, whether cases are now occurring in countries with less well developed surveillance systems and not coming to international attention.Are we seeing only part of the global picture?Neither natural immunity from earlier strains of influenza A nor currently available vaccines offer protection against swine flu.This new strain is, at this stage, sensitive to antiviral drugs oseltamivir and 1
The Growing Role Of Computers In Medicine
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MASSACHUSETTS "ALLOPATHS."
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diphtheria Immunization
Authors: James G. Roney
Journal: JAMA (1961)

<h3>To the Editor:—</h3> I noted in the "Questions and Answers" section ofThe Journal, March 4, 1961, page 832, in regard to diphtheria immunization, that Dr. Wallace E. Herrell stated that there was no need for continuing booster injections of diphtheria toxoids in adults. With the frequently recurring outbreaks of diphtheria in different urban localities, particularly among adults and nonimmunized children, it would appear that there is a need for continued adult protection. One way of providing for this is by means of "adult type" diphtheria tetanus toxoid which does not require Schick-testing before administration. (See Graham, B. S.; Blum, H. L.; and Green, T. W.,<i>JAMA</i><b>166</b>:1586-1588 [March 29] 1958).
Clinical phonocardiography. I. General principles
Authors: M. E. Tavel
Journal: JAMA (1967)

Phonocardiography, the graphic recording of heart sounds and murmurs, has become an indispensable tool in many clinics and teaching centers. For proper understanding of this technique, a few fundamental concepts of sound and its recording first must be reviewed.<sup>1</sup> Cardiovascular sound, like all other sound, is a vibratory phenomenon in which a suitable medium (such as air or body tissues) is caused to vibrate back and forth. The number of complete vibrations per unit time is the so-called<i>frequency</i>and is usually expressed in<i>cycles per second</i>(cps) (Fig 1). These vibrations are propagated through the various media, and, if allowed to reach the tympanic membrane and set this structure into motion, the vibrations are appreciated by the brain as<i>sound</i>. Only those vibrations having frequencies of 20 to 20,000 cps are so appreciated by human audition, and frequencies below or above this 20 to 20,000 range are termed
Fifteen Months' Experience of Electric Illumination of the Bladder, in the Diagnosis of Obscure Vesical Disease
Authors: E. H. Fenwick
Journal: BMJ (1889)

by S.He had also a roseolar rash on the abdomen, cervical and inguinal glands enlarged, none in the axilla, slight ulceration of both tonsils, and condylomata.He was tattooed on June 15th, 1888, and ulcers appeared on August 24th, an incubation of 41 days.He had never before had syphilis.The patient was not admitted to hospital, but permitted to accompany his regiment to Malta.He stated that S. neither put his needles in his mouth, nor used his saliva when tattooing.CASE XII.-Private W
Addendum for Euro Surveill. 2018;23(10)
Journal: Eurosurveillance (2018)

© This work is licensed under a Creative Commons Attribution 4.0 International License. Addendum This article is an addendum to the following content: Outbreak of febrile gastroenteritis caused by Listeria monocytogenes 1/2a in sliced cold beef ham, Italy, May 2016
Erratum to ‘Connexin43 peptide, TAT-Cx43266–283, selectively targets glioma cells, impairs malignant growth, and enhances survival in mouse models in vivo’
Authors: Myriam Jaraíz-Rodríguez, Rocío Talaverón, Laura García-Vicente, Sara G Pelaz, Marta Domínguez-Prieto, Andrea Álvarez-Vázquez, Raquel Flores-Hernández, Wun Chey Sin, John Bechberger, José M Medina, Christian C Naus, Arantxa Tabernero
Journal: Neuro-Oncology (2020)
THE TRANSMUTATION OF SPECIES IN BACTERIOLOGY.
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Questions and Answers
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Long non-coding RNA linc00673 regulated non-small cell lung cancer proliferation, migration, invasion and epithelial mesenchymal transition by sponging miR-150-5p
Authors: Wei Lu, Honghe Zhang, Yuequn Niu, Yongfeng Wu, Wenjie Sun, Hongyi Li, Jianlu Kong, Kefeng Ding, Han-Ming Shen, Han Wu, Dajing Xia, Yihua Wu
Journal: Molecular Cancer (2017)

The function of a new long non-coding RNA linc00673 remains unclear. While identified as an oncogenic player in non-small cell lung cancer (NSCLC), linc00673 was found to be anti-oncogenic in pancreatic ductal adenocarcinoma (PDAC). However whether linc00673 regulated malignancy and epithelial mesenchymal transition (EMT) has not been characterized. Cell proliferation was assessed using CCK-8 and EdU assays, and cell migration and invasion were assessed using scratch assays and transwell invasion assays. Epithelial mesenchymal transition was examined using western blot, qRT-PCR and immunofluorescence staining. Interaction between miRNA and linc00673 was determined using luciferase reporter assays. In vivo experiments were performed to assess tumor formation. In addition, the expression data of NSCLC specimens of TCGA and patient survival data were utilized to explore the prognostic significance of linc00673. In the present study, we found high linc00673 expression was associated with poor prognosis of NSCLC patients. In vitro experiments showed linc00673 knockdown reversed TGF-β induced EMT, and miR-150-5p was predicted to target linc00673 through bioinformatics tools. Overexpression of miR-150-5p suppressed lin00673's expression while inhibition of miR-150-5p led to significant upregulation of lin00673, suggesting that linc00673 could be negatively regulated by miR-150-5p, which was further confirmed by the inverse correlation between linc00673 and miR-150-5p in NSCLC patients' specimen. Furthermore, we proved that miR-150-5p could directly target linc00673 through luciferase assay, so linc00673 could sponge miR-150-5p and modulate the expression of a key EMT regulator ZEB1 indirectly. In addition, miR-150-5p inhibition abrogated linc00673 silence mediated proliferation, migration, invasion and EMT suppressing effect. Moreover, the inhibition of linc00673 significantly attenuated the tumorigenesis ability of A549 cells in vivo. We validated linc00673 as a novel oncogenic lncRNA and demonstrated the molecular mechanism by which it promotes NSCLC, which will advance our understanding of its clinical significance.
MRI
Authors: Bill Holm
Journal: Annals of Internal Medicine (2004)

Ad Libitum6 April 2004MRIBill HolmBill HolmFrom Minneota, MN 56264.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-140-7-200404060-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Only the lead gift in the ... Author, Article, and Disclosure InformationAffiliations: From Minneota, MN 56264.Current Author Address: Bill Holm, Southwest Minnesota State University, 108 South Jefferson, Minneota, MN 56264. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 6 April 2004Volume 140, Issue 7Page: 576KeywordsBoneBreadDiazepamMeatMusclesRibsSpine ePublished: 6 April 2004 Issue Published: 6 April 2004 Copyright & PermissionsCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...