tbuckley/cabot-search huggingface dataset:
Reference Directories
Journal: JAMA (1995)

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NI-38 * GLIOBLASTOMA SUBTYPES DEFINED BY QUANTITATIVE IMAGING MAP TO DIFFERENT CANONICAL SIGNALING PATHWAYS
Authors: H. Itakura, A. Achrol, J. Loya, L. Mitchell, T. Azad, S. Echegaray, K. Yeom, S. Napel, G. Harsh, O. Gevaert
Journal: Neuro-Oncology (2014)

We sought to discover subtypes of glioblastoma (GBM) defined by quantitative imaging features and to identify their canonical signaling pathways. Preoperative MR imaging from 121 Stanford patients with de novo, focal, unilateral GBM were analyzed. Two board-certified neuroradiologists and a neurosurgeon reached consensus in delineating Regions-of-Interest (ROIs) around areas of enhancement in each T1 post-contrast MR. We extracted 138 quantitative image features representing signal intensity and morphology of each lesion. We then used Consensus Clustering to define subtypes in the Stanford group. Next, Prediction Analysis for Microarrays (PAM) and the In-Group Proportion (IGP) statistic were used to validate the reproducibility and robustness of our subtype classification in a second cohort of subjects from The Cancer Genome Atlas (TCGA, n = 145). Finally, to map imaging subtypes to particular molecular signaling pathways, we performed Significance Analysis of Microarrays (SAM) on pathway activity estimates derived from analysis of TCGA tumor copy number and RNA sequencing data with the PARADIGM algorithm. Consensus Clustering analysis of the training set identified three clusters whose validity was confirmed in the TCGA cohort (p < 0.0001, p< 0.0001, p = 0.015). Cluster sizes for the TCGA validation cohort (i.e. 45%, 21% and 35%) were similar to those in the Stanford training set (57%, 17% and 26%). Cluster 1 was associated with 49 overexpressed pathways (FDR < 5%) including Wnt, hypoxia, apoptosis, cell proliferation, and angiogenesis signaling pathways while Cluster 2 was characterized by downregulation of these pathways (FDR < 5%). No pathway was significantly associated with Cluster 3. We identified three distinct, robust clusters of focal, unilateral GBM defined by quantitative image signatures. Subtypes identified in a homogeneous Stanford training set were validated in the heterogeneous multi-institutional TCGA data set. Two of our three clusters had significant associations with canonical signaling pathways.
Abstract LB-104: Functional genomic screening identifies USP11 as a novel therapeutic target in breast cancer
Authors: Darran O’Connor, Lisa Dwane, Aisling O’Connor, Rene Bernards, William Gallagher
Journal: Cancer Research (2016)

Abstract The estrogen receptor (ER) is the principal driver of growth and differentiation in breast cells and de-regulated receptor function is a key feature of almost 75% of breast cancers. Here, we investigated the role of de-ubiquitinating enzymes (DUBs), which act to remove ubiquitin moieties from proteins, in regulating the transcriptional activity of ER in breast cancer. To identify DUBs involved in the regulation of ER transcriptional activity, we performed an RNAi loss-of-function screen using a library of shRNA vectors targeting all known human DUB genes (108 genes/432 shRNAs in total). We found that suppression of a number of DUBs markedly repressed or enhanced the activity of an estrogen-response-element (ERE) luciferase reporter to estradiol (E2). In particular, suppression of the BRCA2-associated DUB, USP11, was found to down-regulate ERα transcriptional activity (both in the presence and absence of E2), as demonstrated by a pronounced decrease in estrogen-response element (ERE) luciferase reporter activity. Subsequent validation of the screen using multiple individual hairpins and ZR-75-1 stable USP11 knockdown cells confirmed the suppression of ERE-reporter activity and further revealed a notable reduction in expression of the endogenous ER target genes TFF1 and PgR following USP11 knockdown. Growth assays and Western blot analysis also revealed a global decrease in cell survival, decreased ERK and AKT phosphorylation and increased sensitivity to DNA-damaging agents in USP11 knockdown cell lines. In silico analysis of publically available breast cancer gene expression datasets revealed a highly significant association between high USP11 mRNA levels and poor prognosis. We observed a highly significant correlation between high expression of USP11 mRNA in ER positive patients and poor overall survival (OS)(HR 1.51, CI 1.07-2.14, p = 0.018) and distant metastasis-free survival (DMFS)(HR 1.35, CI 1.04-1.73, p = 0.023). This correlation was also significant in ER positive patients who had received endocrine therapy (OS, HR 3.4, CI 1.2-9.81, p = 0.014), DMFS, HR 2.16, CI 1.23-3.8, p = 0.0083). Tissue microarray validation using immunohistochemistry in an independent cohort (n = 144) confirmed USP11 as an independent marker of poor prognosis in ER+ breast cancer. These results suggest a role for USP11 in driving cellular growth and identifiy USP11 as a rationale and novel therapeutic target in breast cancer. Citation Format: Darran O’Connor, Lisa Dwane, Aisling O’Connor, Rene Bernards, William Gallagher. Functional genomic screening identifies USP11 as a novel therapeutic target in breast cancer. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr LB-104.
Total Therapy With Tandem Transplants for Newly Diagnosed Multiple Myeloma
Authors: B. Barlogie, S. Jagannath, K.R. Desikan, S. Mattox, D. Vesole, D. Siegel, G. Tricot, N. Munshi, A. Fassas, S. Singhal, J. Mehta, E. Anaissie, D. Dhodapkar, S. Naucke, J. Cromer, J. Sawyer, J. Epstein, D. Spoon, D. Ayers, B. Cheson, J. Crowley
Journal: Blood (1999)
Intradermal bullous dermatitis due to candidiasis in an immunocompromised patient
Authors: S. Suster
Journal: JAMA (1987)

DISSEMINATED candidiasis has become one of the most frequent complications in immunocompromised patients.<sup>1</sup>In some cases this may be difficult to establish, because<i>Candida</i>organisms are cultured from blood samples in only 25% of patients with systemic disease<sup>2</sup>and serological tests may prove to be unreliable.<sup>3</sup>Superficial cutaneous involvement by<i>Candida</i>organisms in immunocompromised patients is a wellrecognized complication; however, hematogenous spread to the skin is rare. A variety of skin lesions have been described in association with disseminated candidiasis, including subcutaneous nodules and pustules,<sup>4</sup>verrucous plaques,<sup>5</sup>macronodular hemorrhagic lesions,<sup>6</sup>maculonodular rash,<sup>7</sup>diffuse erythematous papular rash,<sup>8</sup>necrotic pustules and ulcerative plaques mimicking ecthyma gangrenosum,<sup>9,10</sup>and purpura fulminans.<sup>11</sup>We report a previously undescribed complication of disseminated candidiasis, presenting as extensive hemorrhagic and bullous skin lesions. Histological examination of the lesions revealed intradermal bulla formation with massive involvement by<i>Candida</i>organisms. Early recognition
Gemcitabine versus Gemcitabine???Carboplatin for Patients with Advanced Non-small Cell Lung Cancer and a Performance Status of 2: A Prospective Randomized Phase II Study of the Hellenic Cooperative Oncology Group
Authors: Paris A. Kosmidis, Meletios-Athanasios Dimopoulos, Konstantinos Syrigos, Costas Nicolaides, Gerasimos Aravantinos, Ioannis Boukovinas, Dimitrios Pectasides, George Fountzilas, Dimitrios Bafaloukos, Charalampos Bacoyiannis, Haralampos P. Kalofonos
Journal: Journal of Thoracic Oncology (2007)
Condom Innovation
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
INDUSTRIAL NOISE AND IMPAIRED HEARING
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prognosis grim for internal carotid stenosis
Authors: W. A. Check
Journal: JAMA (1982)

Stenosis of the intracranial internal carotid arteries is an extremely dangerous condition, according to a retrospective study from the Cleveland Clinic. At the recent Joint Conference on Stroke and Cerebral Circulation in New Orleans, David Marzewski, MD, reported that 40% of these patients die during the five years after diagnosis. Others at the meeting agreed with Marzewski that the dire prognosis of this condition emphasizes the importance of a multicenter, randomized trial that is currently in progress to determine whether external carotid-internal carotid (EC-IC) bypass surgery or antiplatelet therapy can improve life expectancy. Sixty-nine patients seen at the Cleveland Clinic between 1966 and 1977 who had greater than 50% angiographically proved stenosis of an intracranial internal carotid artery were identified by Marzewski, neurologist Anthony Furlan, MD, neurosurgeon John Little, MD, and radiologist Michael Modic, MD. The diagnosis in 24 cases was transient ischemic attacks (TIAs) and in 22 cases, stroke.
Alternate Day Fasting Improves Physiological and Molecular Markers of Aging in Healthy, Non-obese Humans
Authors: Slaven Stekovic, Sebastian J. Hofer, Norbert Tripolt, Miguel A. Aon, Philipp Royer, Lukas Pein, Julia T. Stadler, Tobias Pendl, Barbara Prietl, Jasmin Url, Sabrina Schroeder, Jelena Tadic, Tobias Eisenberg, Christoph Magnes, Michael Stumpe, Elmar Zuegner, Natalie Bordag, Regina Riedl, Albrecht Schmidt, Ewald Kolesnik, Nicolas Verheyen, Anna Springer, Tobias Madl, Frank Sinner, Rafael de Cabo, Guido Kroemer, Barbara Obermayer-Pietsch, Jörn Dengjel, Harald Sourij, Thomas R. Pieber, Frank Madeo
Journal: Cell Metabolism (2020)
Book Review The Collected Papers of the Mayo Clinic and the Mayo Foundation for 1928, Volume XX . Edited by Mrs. M. H. Mellish, Richard M. Hewitt, M.D., and Mildred A. Felker, B.S. Octavo volume of 1197 pages with 288 illustrations. Philadelphia and London: W. B. Saunders Company. 1929. Cloth, $13.00 Net.
Journal: New England Journal of Medicine (1929)
Fracture of the Month 28 Number
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Comparison of characteristics from White‐ and Black‐Americans with venous thromboembolism: A cross sectional study
Authors: John A. Heit, Michele Beckman, Paula Bockenstedt, Althea Grant, Nigel Key, Roshni Kulkarni, Marilyn Manco‐Johnson, Stephan Moll, Thomas Ortel,, Claire Philipp
Journal: American Journal of Hematology (2010)

Grant uses the hypothesis of Lindqvist et al. that “variations in vitamin D status might be a possible cause for the seasonal variations in thromboembolic complications” [1] to support his hypothesis that lower serum 25(OH)D levels account for the “disparities of thromboembolism among Black-Americans.” Unfortunately, no studies have directly tested either hypothesis. Specifically, no study has tested serum 25(OH)D as a potential risk factor for incident venous thromboembolism (VTE) after controlling for other known VTE risk factors nor has any study shown that vitamin D3 supplementation reduces VTE risk among Blacks, or among any other race or ethnicity. Lindqvist et al. used data from the Melanoma Inquiry of Southern Sweden [2] to test the hypothesis that sun exposure is a predictor of reduced VTE incidence. MISS enrolled an age-stratified sample of native-born Swedish women (25 to 64 years of age; n = 39,973) with no history of cancer. Participating women completed standardized written questionnaires regarding sun exposures at enrollment (1990–1992) and follow-up (2000–2002). Additional data were collected regarding births, marital status, education level, alcohol consumption, tobacco smoking, body mass index (BMI), hormone use, physical exercise, and cancer. VTE events were identified by questionnaire and hospital discharge diagnosis codes. Lindqvist et al. conclude that sun exposures (i.e., sun bed use, working outdoors in summer, sunbathing during winter vacation or during summer) predicted a 30% reduction in VTE “risk” after adjusting for age, number of births, smoking, BMI, physical activity, and cancer, but no adjustment was made for the major VTE risk factors of surgery, hospitalization for medical illness or trauma/fracture [3]. Moreover, for most of the Lindqvist analyses, the VTE risk reduction related to sun exposure was nonsignificant. Lindqvist further suggests that the “number” of VTE events is about 30% higher in winter compared to the other seasons, but other studies found a higher VTE occurrence in Autumn [4] or Summer [5] or no variation by season at all [6]. Thus, even the indirect evidence for serum 25(OH)D as a VTE risk factor is inconsistent or absent altogether. Consequently, we believe it is premature and potentially dangerous to suggest that Black-Americans supplement with vitamin D3 as a means of reducing “their risk of venous thromboembolism.” John A. Heit [email protected]*, Michele Beckman*, Paula Bockenstedt*, Althea Grant*, Nigel Key*, Roshni Kulkarni*, Marilyn Manco-Johnson*, Stephan Moll*, Thomas Ortel,*, Claire Philipp*, for the CDC Thrombosis and Hemostasis Centers Research and Prevention Network * Stabile 6-Hematology Research, Mayo Clinic,200 First Street, SW, Rochester, MN 55905.
Complications of cirrhosis: Encephalopathy, ascites and cardiopulmonary aspects
Journal: Hepatology (1995)

Vascular dysfunction in both conduit arteries and small vessels is a major contributor to the development of cardiovascular disease (CVD) in diabetes mellitus (DM). In diabetes there is a process of systemic chronic inflammation accompanied by high oxidative stress causing a subsequent decrease in vascular reactivity and negatively affect the metabolic processes responsible for functioning of the microvasculature. Vitamin E is classified as an antioxidant due to its ability to scavenge lipid radicals and terminate oxidative chain reactions. We conducted a double-blinded cross-over study with vitamin E versus placebo in individuals with type 2 DM and the Hp2-2 genotype and assessed different aspects of peripheral vascular function in these patients. Twenty patients completed the study with 10 individuals in each study cohort. We were able to show significant improvement of indirect indices of vascular function following 8 weeks of treatment with vitamin E. This improvement was consistent for weeks even after stopping the vitamin E treatment. We concluded that a pharmacogenomic rationale utilizing the Hp genotype might potentially provide cardiovascular benefit with vitamin E.
Long-Term Medical Care of Testicular Cancer Survivors
Authors: Kevin T. Tong
Journal: Annals of Internal Medicine (2003)

Letters4 March 2003Long-Term Medical Care of Testicular Cancer SurvivorsKevin T. Tong, MDKevin T. Tong, MDFrom Arvada, CO 80002.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-138-5-200303040-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I was disappointed that Vaughn and colleagues' review of testicular cancer treatment (1) did not mention gynecomastia as an important clue to the presence of human chorionic gonadotropin (HCG)secreting tumors. Although gynecomastia occurs in fewer than 10% of patients with testicular cancer, it is one of the more specific findings on physical examination for HCG-secreting neoplasms and should bring the diagnosis to mind, particularly if the onset of gynecomastia is recent or sudden. Gynecomastia secondary to HCG is due to the luteinizing hormonelike activity of high levels of HCG, which stimulates a relative excess of estradiol secretion ...Reference1. Vaughn DJ, Gignac GA, Meadows AT. Long-term medical care of testicular cancer survivors. Ann Intern Med. 2002;136:463-70. [PMID: 11900499] LinkGoogle Scholar Author, Article, and Disclosure InformationAuthors: Kevin T. Tong, MDAffiliations: From Arvada, CO 80002. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoLong-Term Medical Care of Testicular Cancer Survivors David J. Vaughn , Gretchen A. Gignac , and Anna T. Meadows Long-Term Medical Care of Testicular Cancer Survivors David J. Vaughn and Anna T. Meadows Metrics 4 March 2003Volume 138, Issue 5Page: 437KeywordsEstradiolEstrogensFollicle-stimulating hormoneHuman chorionic gonadotropinLong-term careLuteinizing hormonePatientsTestesTesticular cancerTestosterone ePublished: 4 March 2003 Issue Published: 4 March 2003 Copyright & PermissionsCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
SEA-WATER INJECTIONS
Authors: J. R. Day
Journal: BMJ (1911)

<h3>BACKGROUND AND PURPOSE:</h3> Previous studies investigating MR imaging abnormalities among fighters have had small sample sizes. This investigation assessed a large number of fighters using the same conventional sequences on the same scanner. <h3>MATERIALS AND METHODS:</h3> Conventional 3T MR imaging was used to assess 499 fighters (boxers, mixed martial artists, and martial artists) and 62 controls for nonspecific WM changes, cerebral microhemorrhage, cavum septum pellucidum, and cavum vergae. The lengths of the cavum septum pellucidum and cavum vergae and the ratio of cavum septum pellucidum to the septum pellucidum lengths were assessed. <h3>RESULTS:</h3> The prevalence of nonspecific WM changes was similar between groups. Fighters had a prevalence of cerebral microhemorrhage (4.2% versus 0% for controls, <i>P</i> = .152). Fighters had a higher prevalence of cavum septum pellucidum versus controls (53.1% versus 17.7%, <i>P</i> &lt; .001) and cavum vergae versus controls (14.4% versus 0%, <i>P</i> &lt; .001). The lengths of the cavum septum pellucidum plus the cavum vergae (<i>P</i> &lt; .001), cavum septum pellucidum (<i>P</i> = .025), and cavum septum pellucidum to the septum pellucidum length ratio (<i>P</i> = .009) were higher in fighters than in controls. The number of fights slightly correlated with cavum septum pellucidum plus cavum vergae length (<i>R</i> = 0.306, <i>P</i> &lt; .001) and cavum septum pellucidum length (<i>R</i> = 0.278, <i>P</i> &lt; .001). When fighters were subdivided into boxers, mixed martial artists, and martial artists, results were similar to those in the whole-group analysis. <h3>CONCLUSIONS:</h3> This study assessed MR imaging findings in a large cohort demonstrating a significantly increased prevalence of cavum septum pellucidum among fighters. Although cerebral microhemorrhages were higher in fighters than in controls, this finding was not statistically significant, possibly partially due to underpowering of the study.