tbuckley/cabot-search huggingface dataset:
The differential diagnosis of impotence. The measurement of nocturnal penile tumescence
Authors: M. D. Wasserman
Journal: JAMA (1980)

The literature on nocturnal penile tumescence (NPT) and impotence is briefly reviewed. Available evidence suggests that measurement of NPT provides objective data, which when combined with a thorough clinical evaluation can be helpful in distinguishing psychogenic from organic impotence in approximately 80% of those patients who present this differential diagnostic problem. Further research is needed to determine whether some psychogenically impotent patients may have impaired NPT. The interdisciplinary evaluation employed at our center is described, and clinical material illustrating the usefulness of this technique is presented. The potential errors that can result from the use of portable NPT monitoring devices are discussed. (<i>JAMA</i>243:2038-2042, 1980)
Transplantation, Immunosuppression, and Oncogenesis
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
New Format for References and Reviews
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Superfemale?
Authors: Philip Ball
Journal: JAMA (1964)

<h3>To the Editor:—</h3> I ran across an odd report the other day while perusing the medical literature. It concerned a type of sex chromosome anomaly characterized by a chromosomal number of 47 and a chromosomal sex of XXX, and the authors used the term "super female" as a designation for this entity. The report went on to describe a female of average height, but with underdeveloped breasts, infantile external genitalia, and a small vagina.<sup>1</sup> It goes to show that it's all a matter of one's point of view, which in this case was obviously chromosomal. From the somatic standpoint such an individual would be better called an "infrafemale" or a "hypofemale."
Gay, lesbian physicians meet, march, tell Shalala bigotry is health hazard
Authors: P. Cotton
Journal: JAMA (1993)

A LINE of several hundred people curled all the way around the atrium at Union Station in Washington, DC, unable to get into the largest gathering ever of gay and lesbian physicians. The American Association of Physicians for Human Rights (AAPHR) reception at Union Station's Columbus Club was jammed with some 1500 gay and lesbian physicians and their same-sex spouses or partners—well over three times the number organizers expected. These physicians were in the nation's capital last month to take part in the March on Washington for Lesbian, Gay, and Bi Equal Rights and Liberation. Gay and lesbian physicians and other health care providers also met with Health and Human Services (HHS) Secretary Donna Shalala, PhD, her top aides, and key House of Representatives and Senate staff members to discuss a wide range of homosexual health issues, from acquired immunodeficiency syndrome to high rates of substance abuse and teen suicide,
Treatment of Early-Stage Breast Cancer
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction to: Activation of LncRNA TINCR by H3K27 acetylation promotes Trastuzumab resistance and epithelial-mesenchymal transition by targeting MicroRNA-125b in breast Cancer
Authors: Huaying Dong, Jianguo Hu, Kejian Zou, Mulin Ye, Yuanwen Chen, Chengyi Wu, Xin Chen, Mingli Han
Journal: Molecular Cancer (2021)
Genu Valgum
Authors: H. Davies
Journal: BMJ (1948)

<h3>Abstract</h3> SOCS3 is the main inhibitor of the JAK/STAT3 pathway. This pathway is activated by interleukin 6 (IL-6), a major mediator of the cytokine storm during shock. To determine its role in the vascular response to shock, we challenged mice lacking SOCS3 in the adult endothelium (SOCS3<sup>iEKo</sup>) with a non-lethal dose of lipopolysaccharide (LPS). SOCS3<sup>iEKo</sup> mice died 16-24 hours post-injection after severe kidney failure. Loss of SOCS3 led to an LPS-induced type I interferon-like program, and high expression of pro-thrombotic and pro-adhesive genes. Consistently, we observed intraluminal leukocyte adhesion and NETosis, as well as retinal venular leukoembolization. Notably, heterozygous mice displayed an intermediate phenotype, suggesting a gene dose effect. In vitro studies were performed to study the role of SOCS3 protein levels in the regulation of the inflammatory response. In HUVEC, pulse-chase experiments showed that SOCS3 protein has a half-life below 20 minutes. Inhibition of SOCS3 ubiquitination and proteasomal degradation leads to protein accumulation and a stronger inhibition of IL-6 signaling and barrier function loss. Together, our data demonstrates that the regulation of SOCS3 protein levels is critical to inhibit IL-6-mediated endotheliopathy during shock and provides a promising new therapeutic avenue to prevent MODS though stabilization of endothelial SOCS3. <h3>Graphical abstract</h3>
Reports ON MEDICAL AND SURGICAL PRACTICE IN HOSPITALS AND ASYLUMS
Authors: F Stedman
Journal: BMJ (1915)

THE BRms 4 contact wvith tlle fraenum linguae.I showed the case to fouir of my colleagues here, and as none of them had ever scen or lieard of anyone who could perform this feat, I tlouglt it rmight be of interest to put it on record.
Retrodisplaced Gravid Uterus
Authors: J. A. Chalmers
Journal: BMJ (1947)

BKIlOStL too all the signs of meningism, including nuchal rigidity and Kernig's sign.Blood films on admission were negative for malarial parasites, but despite this and during preparations for withdrawal of C.S.F. it was suggested that he be given intravenous quinine, 10 gr. (0.65 g.).Half an hour after administration delirium had ceased, and lying comfortably in bed he spoke quietly and coherently and was curious to know what had happened to him.Examination of the C.S.F. was then carried out and meningitis excluded as a concomitant condition.Malaria is a great simulator, and while not having had the opportunity of reading Dr. Walter Broadbent's letter (Jan. 4,p. 32) I conclude this fact was uppermost in his mind when approaching his case.-Iam, etc.,
Pulmonary alveolar proteinosis: a complete response to GM-CSF therapy
Authors: R M Barraclough, A J Gillies
Journal: Thorax (2001)

Pulmonary alveolar proteinosis is a rare condition traditionally requiring treatment with whole lung lavage. The case is presented of a young man who obtained complete remission following treatment with granulocyte-macrophage colony stimulating factor, a new treatment option.
December 16, 1998
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Errors in Data Presentation, Funding, and Acknowledgments
Journal: JAMA Cardiology (2018)

Hao Yu Chen, MSc; Line Dufresne, MSc; Hannah Burr, BSc; Athithan Ambikkumar, HSDG; Niko Yasui, BSc; Kevin Luk, BSc; Dilrini K. Ranatunga, BA; Rachel A. Whitmer, PhD; Mark Lathrop, PhD; James C. Engert, PhD; George Thanassoulis, MD, MSc
Primary cancer of the breast.
Journal: BMJ (1970)

describes the collaborative work of the Cam- bridge-King's College Hospital units, and discusses the place, results, complications, and outlook for liver transplantation (p.585).Primary Amoebic Meningoencephalitis: Account of the Bristol outbreak in which two children were infected by amoebae (naegleria) probably derived from a puddle.The first child died (p.596).Leader at p. 581.Postgraduate Education: The Central Committee for Hospital Medical Services decided to reject specialist registration as outlined by Todd and the G.M.C.It wants a central register for preregistration appointments, no compulsory general professional training for hospital doctors, and progressive assessment rather than a single "pass or fail" exam (Supplement, p. 47).Cord Compression: Refresher course article on the varieties of paraplegia, their causes and management (p.611).Meniere's Disease: Clinical features and medical and surgical treatment (p.614).Other Clinical Studies: Successful method for preparing high-titre anti-D serum (p.593), change in cellular immunity with malignant transformation of Kaposi's sarcoma (p.600), incidence of urinary infection in children (p.602), methysergide and pleural effusion (p.605), bioassay for "thrombopoietin" (p.606), intrauterine transfusion of twins (p.609), and gold-induced nephrotic syndrome (p.624).Routine Multiple Blood Tests: Their random use in general practice led to a significant new diagnosis in nearly 17 I/ of patients (p.620).Breast Cancer: Choice of treatment.Leader at this page.
Expressions of basic fibroblast growth factor and its receptors and their relationship to proliferation of human hepatocellular carcinoma cell lines
Authors: S Ogasawara
Journal: Hepatology (1996)

On six human hepatocellular carcinoma (HCC) cell lines (KIM-1, KYN-1, KYN-2, KYN-3, HAK-1A, and HAK-1B), we examined expressions and functions of the proteins and messenger RNAs (mRNAs) of basic fibroblast growth factor (bFGF) and its receptor, i.e., fibroblast growth factor receptor-1 (FGFR-1), as well as mRNA expressions of FGFR-2 approximately 4. All six cell lines expressed the proteins and mRNAs of bFGF and FGFR-1, and at least one of FGFR-2 approximately 4 mRNAs. Two of the six cell lines (KYN-1 and KYN-3) presented significant release of bFGF in culture supernatant, while the release in the remaining four cell lines was quite small. Addition of anti-bFGF neutralizing antibody (1, 10, or 20 microg/mL) to culture medium resulted in marked suppression of cell proliferation in all cell lines except HAK-1A. On the other hand, addition of exogenous bFGF (0.1, 1, or 5 ng/mL) to culture medium stimulated cell proliferation except in KIM-1 and KYN-2. When KIM-1 was transplanted to nude mice and anti-bFGF antibody was injected subcutaneously to a space surrounding the developed tumor, tumor proliferation was significantly suppressed in nude mice that received anti-bFGF antibody than in control mice, but there were no histological differences between the groups, including blood space formation in the stroma. In conclusion, hepatocellular carcinoma (HCC) cells may possess a proliferation mechanism regulated by an autocrine mechanism, a paracrine mechanism, or both, which are mediated by bFGF/FGFR.
Book Review Medical Diseases of War . By Sir Arthur Hurst, D.M. (Oxon.), F.R.C.P., with the co-operation of H. W. Barber, M.D. (Cantab.), F.R.C.P., F. A. Knott, M.D. (Lond.), M.R.C.P., and T. A. Ross, M.D. (Edin.), F.R.C.P. 8°, cloth, 327 pp., with 37 illustrations and 4 plates. Baltimore: Williams and Wilkins Company, 1940. $5.50.
Journal: New England Journal of Medicine (1941)
Section E. NEW TECHNIQUES
Authors: L Ekelund, Suzan Livingston, J Williams, P Cavanagh, D Grieve
Journal: British Journal of Sports Medicine (1973)

The control system of an electrically braked ergometer (Elema corp.) has been changed in order to include the possibility to obtain an arbitrarily chosen heart rate automatically.The control unit consists of a heart rate meter triggered by ECG and a servosystem which is constructed to give a smooth load and heart rate response and to hold the present heart rate within about ± 3 beats/min.There are analog signals for recording of the heart rate, load and integrated load.The practical applications will be discussed and demonstrated.
The Environment
Authors: William D. Norwood
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 18790: Identification of a Novel Regulator of the Mesenchymal Stem Cell Secretome and Myocardial Repair
Authors: Feng Dong, Matthew Kiedrowski, Marc Penn, Mary E Mayorga
Journal: Circulation (2015)

The delivery of mesenchymal stem cells (MSC) in acute myocardial infarction (AMI) leads to significant preservation of myocardium and improved cardiac function. We have previously shown that the down-regulation of the tumor suppressor protein disabled-2 (Dab2) leads to increased MSC function in AMI. We sought to define the molecular mechanisms associated with down-regulation of disabled-2 and improved MSC function. We observed that the improvement in cardiac function following engraftment of Dab2-/- MSC was associated with modulation of the MSC secretome, in that of conditioned media conferred the same benefits as cell transplantation. To begin to define the down-stream targets of disabled-2 we completed a detailed Illumina array comparing Dab2 down-regulation by three methods (MSC treated with TGFß1 or MSC transfected with miR-145 or dab2:siRNA). Comparing gene expression in these three treatment groups to control MSC we identified 23 genes whose expression were similarly significantly modulated by dab2 down-regulation. Of this group we have focused to date on CAMKK1 as a possible regulator of the MSC secretome. CAMKK1, is a kinase with multiple down-stream targets including CAMK1, CAMKIV and Akt. Inhibition of CAMKK1 leads to an increase in pro-inflammatory cytokines and chemokines in the conditioned media of MSC. To determine if CAMKK1 over-expression was sufficient to induce an MSC like benefit in AMI we generated a plasmid vector in which CAMKK1 expression is regulated by the CMV promoter and the 5’-UTR RU5 enhancer element. We performed randomized blinded study in an AMI model in Sprague Dawley rats in which 500 ug of plasmid encoding CAMKK1 in 5 divided doses was injected into the infarct borderzone immediately after LAD ligation. CAMKK1 over-expression led to a significant improvement in cardiac function at 1, 2 and 8 weeks after AMI (Ejection Fraction at 8 weeks: CAMKK1: 83.2%±5.4% vs. Placebo: 51.7%±5.8%, p&lt;0.0001, baseline: 91.3%±4.3%). These data suggest that CAMKK1 is a key molecular regulator of the MSC secretome, and that the benefits associated with MSC therapy can be achieved through the direct over-expression of CAMKK1.
Pulmonary thromboembolism in the presence of an endocardiac pacing catheter
Authors: G. B. Prozan
Journal: JAMA (1968)

Thrombosis in the right atrium and ventricle along the course of an implanted catheter pacemaker is a rare occurrence. Subsequent pulmonary emboli complicated congestive heart failure in our patient. Such a complication should be considered when congestive heart failure becomes a prominent problem in patients with implanted catheter pacemaking systems. Prophylactic anticoagulant therapy is not recommended because the problem is still rare in proportion to the number of implanted catheters.
Multiple Megaloblastosis
Authors: CHARLES A. HALL
Journal: Annals of Internal Medicine (1972)

Editorial Notes1 May 1972Multiple MegaloblastosisCHARLES A. HALL, M.D., MARY E. RAPPAZZO, M.S.CHARLES A. HALL, M.D.Search for more papers by this author, MARY E. RAPPAZZO, M.S.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-76-5-826 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDeficiency of vitamin B12(B-12) or folate produces morphologic abnormalities in all three of the most important cells of the blood (1). Precursors of erythrocytes are large in both nucleus and cytoplasm. The chromatin has an open pattern of fine meshwork. The production of hemoglobin is not normally synchronized with cell age. Granulocyte precursors are also large with large nuclei. Nuclei of the later stages are sometimes described as horseshoe-shaped, ribbon-like, or serpentine. Megakaryocytes, as well, show abnormalities in their appearance and lobulation. Peripherally, the erythrocytes are large, although there is a wide range in cell sizes, and the granulocytes...References1. CHANARIN I: The Megaloblastic Anaemias, Oxford, Blackwell Scientific Publications, 1969 Google Scholar2. MASSEYKLAYMAN BM: Observations on epithelial cells exfoliated from the upper gastrointestinal tract of patients with pernicious anemia, simple achlorhydria, and carcinoma of the esophagus and stomach. Am J Med Sci 230:506-514, 1955 CrossrefMedlineGoogle Scholar3. GRAHAMRHEAULT RM: Characteristic cellular changes in epithelial cells in pernicious anemia. J Lab Clin Med 43:235-241, 1954 MedlineGoogle Scholar4. NIXONBERTINO PJ: Interrelationships of vitamin B-12 and folate in man. Am J Med 48:555-561, 1970 CrossrefMedlineGoogle Scholar5. MENZIESCROSSENFITZGERALD RPP: Cytogenic and cytochemical studies on marrow cells in B-12 and folate deficiency. Blood 28:581-594, 1966 CrossrefMedlineGoogle Scholar6. BECK W: The metabolic functions of vitamin B-12. N Engl J Med 266:708-812, 1962 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: CHARLES A. HALL, M.D.; MARY E. RAPPAZZO, M.S.Affiliations: Department of Medicine Albany Medical College of Union University Albany, N.Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHeterocyclic Dyes and PigmentsVolume 1 References 1 May 1972Volume 76, Issue 5Page: 826-827KeywordsBlood cellsCellsChromatinCytoplasmFolic acidGranulocytesHemoglobinMegakaryocytes ePublished: 1 December 2008 Issue Published: 1 May 1972 PDF downloadLoading ...
Sciatic Neuritis
Authors: J. MacD. Holmes, B. R. Sworn
Journal: BMJ (1945)

<h3>Abstract</h3> <b>Overview of:</b> Medicines and Healthcare products Regulatory Agency. Nebulised asthma rescue therapy in children: home use of nebulisers in paediatric asthma should be initiated and managed only by specialists. <i>Drug Safety Update</i> 2022;16:1.