tbuckley/cabot-search huggingface dataset:
<i>CDK12</i>-mutated prostate cancer (PC): Clinical outcomes to standard therapies and immune checkpoint blockade.
Authors: Michael Thomas Schweizer, Roman Gulati, Landon Carter Brown, Rana R. McKay, Tanya B. Dorff, Deepak Kilari, Pankaj Vats, Vaibhav G. Patel, William K. Oh, Andrew J. Armstrong, Robert B. Montgomery, Ajjai Shivaram Alva
Journal: Journal of Clinical Oncology (2020)

191 Background: Translational studies have shown that CDK12 mutations may delineate an immunoresponsive subgroup of PC, characterized by high neoantigen burden. Given that these mutations may define a clinically relevant PC subgroup, we sought to describe outcomes to both standard drugs and PD1 inhibitors. Methods: Clinical data from consecutive patients with CDK12 mutations were retrospectively collected from 7 centers. Multiple clinical grade sequencing assays were used to assess for CDK12 alterations. Descriptive statistics included PSA50 (≥50% decline in PSA from baseline) and clinical/radiographic progression-free survival (PFS). Results: Of 56 CDK12-mutated PC patients, 27 (48%) had biallelic CDK12 alterations. At diagnosis, 46 (82%) had Gleason grade group 4-5 disease, 52% had T3-T4 disease and 15 (27%) had M1 disease. Median follow up was 8.2 yrs (95% CI: 5.6-11.1) and 53 (95%) developed metastatic disease. Median overall survival (OS) from metastasis was 3.9 years (95% CI: 3.2-5.8). Nineteen patients received an anti-PD1 therapy. PSA50 responses to PD1 blockade were infrequent and overall PFS was short (Table); however, the estimated 9-month PFS was 23%. PFS was higher in chemotherapy naïve patients who received anti-PD1 therapy (P=0.004). Outcomes were similar in monoallelic vs. biallelic CDK12-mutated patients. Conclusions: CDK12-mutations define an aggressive PC subgroup, with a high rate of metastatic disease and short OS. Immune checkpoint inhibitors may be effective in a minority of these patients and exploratory analysis supports using anti-PD1 drugs early.[Table: see text]
Evaluation of Total Correction of Tetralogy of Fallot
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TRAVEL NOTES. V.ITALY AND THE GREAT ANTIMALARIAL CAMPAIGN.
Authors: LEWELLYS F. BARKER
Journal: JAMA (1904)

The medico-chirurgical division of the R. Instituto di Studi Superiori at Florence has a strong faculty, though not all the members of the faculty live in Florence, some of them holding professorships also at Pisa, Siena, Modena, Genoa or Cagliari. Grocco is the distinguished clinician there; he has an immense consultation practice, drawing patients from great distances in the country round. Guido Banti has the chair of pathologic anatomy and Eugenio Tanzi that of psyschiatry. Ottone Barbacci, who has written so many thorough collective reviews for the<i>Centralblatt f. allgemeine Pathologie</i>, lectures here on pathologic anatomy, though he is professor in Siena. Gino Galeotti, too, who contributed the much-commented-on article in the last volume of the<i>Zeitschrift für physiologische Chemie</i>on the precipitation of albumins with metals, bringing the whole process under the "phase rule" of the great New Haven physicist, Gibbs, lectures here on general pathology, though
Abstract 334: Cyclic GMP-dependent Protein Kinase Iα Dependent Regulator of G-protein Signaling 2 Activation Is Required for Early Cardiac Compensation to Pressure-overload
Authors: Eiki Takimoto, Elizabeth A Ketner, Norimichi Koitabashi, Manling Zhang, Takahiro Nagayama, Djahida Bedja, Kathleen L Gabrielson, Michael E Mendelsohn, David A Kass
Journal: Circulation (2007)

In response to pressure-overload, the heart initially develops adaptive hypertrophy with enhanced contractility, but later decompensates with chamber dilation. Such maladaptation can be induced by activation of G αq -coupled signaling, whereas enhancing cyclic GMP-dependent protein kinase I-α (PKGI-α) by phosphodiesterase 5A inhibition (PDE5A-I) ameliorates pressure-overload pathobiology. A potential coupler of both pathways is RGS2 (regulator of G-protein signaling 2), which is activated by PKGI-α to suppress G αq -stimulation in vascular smooth muscle cells. Here we tested this signaling in hearts exposed to pressure-overload by transverse aortic constriction (TAC). RGS2 is up-regulated in the particulate fraction of control heart lysate within 48 hours of TAC. Unlike controls, RGS2 −/− hearts display no early compensation to TAC, developing accelerated dilation and severe hypertrophy within 1week, with high mortality (Table ). Downstream signaling of G αq stimulation including ERK1/2, CaM kinase II and calcineurin is markedly activated or up-regulated in RGS2 −/− -TAC versus RGS2 +/+ -TAC. In normal myocytes, RGS2 displays weak diffuse subcellular localization by confocal immunofluorescent histochemistry, whereas PKGI-α has a striated banding pattern. Stimulation of G αq (angiotensin II, 1μM; endothelin 1, 0.5μM) induces translocation of both RGS2 and PKGI-α to the sarcolemmal membrane, which is dependent on PKG activation. Similar translocation is observed in 48hours-TAC myocytes, but it declines by 1 week. Concomitant PDE5A-I (oral sildenafil; 200mg/kg/day) sustains PKGI-α and RGS2 at the membrane in RGS2 +/+ -TAC 1week, ameliorating hypertrophy, whereas PDE5A-I has no effect on RGS2 −/− -TAC 1week (Table ). Thus RGS2 is an essential regulator of early compensation to pressure-overload, is regulated by PKGI-α activation, and also plays a key mechanistic role in the anti-hypertrophic effects from PDE5A inhibitors. Results TAC 1 week (n = 4–6 for hemodynamics in each group)
Saunder's Question-Compends, No. 1, Essentials of Physiology.
Journal: JAMA (1889)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Miscellany
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Salmonellosis — A Review of Some Unusual Aspects
Authors: Paul H. Black, Lawrence J. Kunz, Morton N. Swartz
Journal: New England Journal of Medicine (1960)

MeningitisAlthough one does not include central-nervoussystem involvement among the more frequent complications of salmonellosis, under certain circumstances, particularly in the neonatal age group, salmonella meningitis may be a serious problem. A case that was successfully treated is presented below.Case 8. J.T. (M.G.H. 856328), a 2-month-old male infant, was admitted to the hospital with extensive burns estimated at 70 per cent of the body surface, about 40 per cent being 3d degree. He did well during the 1st month, with supportive therapy, skin grafting and antibiotics for skin infections from which pseudomonas species and Staphylococcus aureus were cultured. One . . .
Diabetic Nephropathy
Authors: MARTIN SCHIMMEL
Journal: Annals of Internal Medicine (1971)

Letters, Comments, and Corrections1 November 1971Diabetic NephropathyMARTIN SCHIMMELMARTIN SCHIMMELSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-75-5-811_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In the August issue of the ANNALS Drs. Strauss, Argy, and Schreiner, in their article "Diabetic Glomerulosclerosis in the Absence of Glucose Intolerance," describe a patient who developed electron microscopic evidence of diabetic nephropathy in the presence of normal glucose tolerance as tested by conventional modalities, with the exception of an abn ormal cortisone glucose tolerance test. They state there was a positive family history for diabetes mellitus, and this, coupled with an abnormal cortisone glucose tolerance test, strongly suggests the possibility of latent diabetes mellitus.Klaus Johansen, in his article "Diabetic Angiopathy in a Patient with Normal... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: MARTIN SCHIMMELAffiliations: Medical College of Pennsylvania Philadelphia, Pa. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byFour-membered Rings with Two or More Heteroatoms and Fused-ring DerivativesVolume 7 References 1 November 1971Volume 75, Issue 5Page: 811-811KeywordsDiabetes mellitusElectron microscopyGlucose intoleranceGlucose toleranceGlucose tolerance tests ePublished: 1 December 2008 Issue Published: 1 November 1971 PDF downloadLoading ...
The Shiga Microalbuminuria Reduction Trial (SMART) Group. Reduction of Microalbuminuria in Patients With Type 2 Diabetes: The Shiga Microalbuminuria Reduction Trial (SMART). Diabetes Care 2007;30:1581–1583. DOI: 10.2337/dc06-2493. Erratum appears in Diabetes Care 2013;36:4172. DOI: 10.2337/dc13-er12
Journal: Diabetes Care (2014)

Based on the review and recommendation of the American Diabetes Association's Subcommittee on Ethical Scientific Publications (ESP), Diabetes Care formally retracts the above-cited article. For reasons described below, the published data are considered to be unreliable. According to an investigation and analysis of the data conducted by Shiga University of Medical Science (report received 25 November 2013), 10.1% of the albumin-to-creatinine ratio (ACR) data reported in the article did not match original patient records. In the valsartan and amlodipine groups, respectively, 12.5% and 8.1% of the ACR data reported in the article differed from patient records. Close examination of these differences showed that ACR values reported for the valsartan group were smaller, and those for the amlodipine group were larger, than values reported in patient records; these differences "worked to the advantage of valsartan." The investigative panel of Shiga University of Medical Science concluded that the above-cited article is "inappropriate for [a] scientific paper."
Hypercarotenemia in anorexia nervosa
Authors: M. A. Pops
Journal: JAMA (1968)

Twelve patients with anorexia nervosa and weight loss ranging from 25% to 44% of total body weight were studied with respect to aberrations in serum carotene levels. Hypercarotenemia was found in nine of the 12. Hypercarotenemia apparently has not been previously described in other forms of human starvation. Other conditions which may lead to disturbances in lipid metabolism and which have been associated with hypercarotenemia were ruled out. An abnormality in lipid metabolism in anorexia nervosa is suggested by these findings.
Massachusetts Institue of Technology Special Summer Program
Journal: JNCI Journal of the National Cancer Institute (1983)

Journal Article Massachusetts Institue of Technology Special Summer Program Get access JNCI: Journal of the National Cancer Institute, Volume 70, Issue 6, June 1983, Page 1171, https://doi.org/10.1093/jnci/70.6.1171-a Published: 01 June 1983
Correction
Journal: BMJ (1902)

mpmbers of the medical profession run every day.He was glad to have an opportunity of saying of his friend William Smyth that no better example of what a medical man should be eould be found.Of splendid physique, the best sailor in a district of fishermpn, a fearless horseman, and an all-round athlete, as well as a man thoroughly grounded in the work of his profession, he was fully appreciated by the people among whom he lived.Dr. WARNOCK (Donegal), who attended Dr. Smyth in his fatal illness, was called upon by the members.He said his heart was too full, close to the anniversary of that tragic and noble death, for him to say much; but he might say that Dr. Smyth, on his deathbed, had told him how, when left alone to minis,er to the poor fever-stricken people of that island, Dr. MeCarthy had come to his aid, and enabled them to bring them safe to the mainland.Of Dr. Smyth he could only say he was one of the noblest of men:One who never turned his back, but marched breast forward- Never doubted clouds would break; Never dreamed, though right were worsted, wrong would triumph.Hleld we fall to rise, are baffled to fight better; Sleep to wake.
Studies on Hemoglobin II. Effect of Anti-Hemoglobin Sera on Red Blood Cells in Vitro and in Vivo
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
LONDON LETTER.
Authors: None G. O. M.
Journal: JAMA (1885)

London, Jan. 7, 1885. A most valuable and important report by the medical officer of the local government board has just been issued as a supplement to the report of the board itself. Dr. Buchanan records the increasing recognition which, under Sir Charles Dilke, the medical staff of the board receives, and says that quite 6,000 questions were referred to it in 1883. His report tells the year's history of vaccination work, of medical inquiries into epidemics, and the communication of diseases by milk; and with a glance at the cholera, passes on to the important scientific investigations made during the year into the chemistry of putrefaction, as well as into questions of infection and disinfection, and the organisms which produce disease. The antivaccinationists have not made much diminution in the use of the great prophylactic against small-pox. The latest returns are for 1881, but they show that only 3.8
GOVERNMENT SERVICES
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AIDS projections: how Farr out?
Authors: M. Artzrouni
Journal: JAMA (1990)

<h3>In Reply.—</h3> With regard to Dr Tetrault's letter, the ±14.2% acceptable range that we used in our study is the correct, total allowable error for a<i>single</i>cholesterol measurement. We refer interested readers to the February 1990 Laboratory Standardization Panel report, which outlines these guidelines for cholesterol measurement.<sup>1</sup>Also, 100% of the cholesterol measurements need to fall within the ± 14.2% range. Dr Tetrault's interpretation of the range for total allowable error is incorrect. The laboratory cholesterol values that we used as a measure of the study participants' true cholesterol levels were adjusted to control for a 5% positive bias found in the measurement method used in our Centers for Disease Control reference laboratory. The precision estimate for the reference method was small (1.3%). We did not assume that our laboratory method was completely without error. Postural and temporal effects can be factors in blood measurements and are rarely
Effect of sodium depletion on renin activity of renal venous plasma in renovascular hypertension
Authors: S. W. Vermillion
Journal: JAMA (1969)

In a patient with renovascular hypertension, renal venous renin-activity determinations were carried out during normal sodium intake, after sodium depletion, and after sodium repletion. When the patient was eating a normal sodium diet, renal venous renin-activity levels failed to lateralize, a finding consistent with the results of isotope renography and two separated renal function studies. However, renal venous renin-activity ratios lateralized (ratios greater than 2:1) to the affected side when the patient's severe sodium depletion lasted for three days. From this finding, it was correctly predicted that relief of hypertension would follow nephrectomy for complete occlusion of a branch artery secondary to fibromuscular dysplasia. Acute sodium depletion increases the diagnostic sensitivity of renal venous renin-activity testing in the determination of functional significance of renovascular lesions in hypertensive patients.
Renal hemodynamic response to maximal vasodilating stimulus in healthy older subjects
Authors: Giorgio Fuiano, Stale Sund, Giuseppe Mazza, Margherita Rosa, Alfredo Caglioti, Giancarlo Gallo, Giuseppa Natale, Michele Andreucci, Bruno Memoli, Luca De Nicola, Giuseppe Conte
Journal: Kidney International (2001)
Personal View
Authors: C. Haffner
Journal: BMJ (1986)

Reproducibility is severely limited if instrument performance is assumed rather than measured. Within optical microscopy, instrument performance is typically measured using sub-resolution fluorescent beads. However, the process is performed infrequently as it is requires time and suitably trained staff to acquire and then process the bead images. Analysis software still requires the manual entry of imaging parameters. Human error from repeatedly typing these parameters can significantly affect the outcome of the analysis, rendering the results less reproducibile. To avoid this issue, PyCalibrate has been developed to fully automate the analysis of bead images. PyCalibrate can be accessed either by executing the Python code locally or via a user-friendly web portal to further improve accessibility when moving between locations and machines. PyCalibrate interfaces with the BioFormats library to make it compatible with a wide range of proprietary image formats. In this study, PyCalibrate analysis performance is directly compared with alternative free-access analysis software PSFj, MetroloJ QC and DayBook3 and is demonstrated to have equivalent performance but without the need for user supervision.
A Primary Care Update: Current Concepts of Common Carcinomas—Breast, Colon, and Prostate
Journal: JNCI Journal of the National Cancer Institute (1987)

Journal Article A Primary Care Update: Current Concepts of Common Carcinomas—Breast, Colon, and Prostate Get access JNCI: Journal of the National Cancer Institute, Volume 79, Issue 3, September 1987, Page 610, https://doi.org/10.1093/jnci/79.3.610-c Published: 01 September 1987