tbuckley/cabot-search huggingface dataset:
Effects of Epinephrine on Coronary Microvascular Diameters
Authors: William M. Chilian, Susan M. Layne, Charles L. Eastham, Melvin L. Marcus
Journal: Circulation Research (1987)

This study was designed to examine the hypothesis that epinephrine has nonuniform effects on coronary microvascular diameters.Measurements of coronary microvascular diameter were completed in anesthetized, open-chest cat preparations in which the epicardial microcirculation was viewed through an intravital microscope using stroboscopic epi-illumination.Images of coronary microvessels were digitized and analyzed on a video monitor.With arterial pressure controlled, measurements in the absence and presence of /3-adrenergic blockade (propranolol 1 mg/kg) were obtained during epinephrine infusion (1-2 /xg/kg/min).In the absence of/3-adrenergic blockade, epinephrine produced a 25% increase in myocardial per fusion.Under these conditions, coronary vasodilation was observed in all classes of coronary arterial and arteriolar vessels.In the presence of /3-adrenergic blockade, epinephrine produced a significant decrease in myocardial perfusion (-20%).Nonuniform effects on diameter were observed in arterial and venous segments of the coronary circulation.These data are consistent with the view that in the absence of /3-adrenergic blockade, the functional coronary hyperemia associated with epinephrine administration is produced by uniform coronary arterial and arteriolar dilation.In the presence of /3-adrenergic blockade, with metabolic effects controlled, epinephrine produced a decrease in myocardial perfusion, which is related to a nonuniform decrease in coronary microvascular diameters.Such heterogeneous effects on microvascular diameters result in a redistribution of coronary microvascular resistance.(Circulation Research 1987;61(suppl II):II-47-11-53) S timulation of cardiac sympathetic nerves or cate- cholamine infusion produces /3-adrenergic receptor-mediated increases in heart rate and myocardial contractility, which result in an increase in coronary blood flow.Concurrent with the metabolic coronary hyperemia, there is activation of a-adrenergic receptors, which produces coronary vasoconstriction. 1 -2 Although there is substantial information regarding pharmacologic and metabolic coronary hyperemia as well as a-adrenergic constriction at the macrovascular level in the coronary circulation, there is a paucity of information regarding the microvascular sites at which such dilation and constrictor mechanisms may occur. 13ttempts to examine segmental a-adrenergic constriction in the coronary circulation have been confined to studies that simultaneously measure large epicardial coronary artery resistance and total coronary vascular resistance.In the intact animal, Kelley and Feigl 4 examined segmental a-adrenergic coronary constrictor mechanisms in large coronary arteries.Large coronary arteries constricted during sympathetic nerve stimulation or norepinephrine infusion following /3-adrenergic
Measuring health care quality
Authors: R. M. Poses
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diagnosing drug allergy
Authors: P. P. Van Arsdel
Journal: JAMA (1982)

CLOSE to 200,000 hospitalized patients suffer allergic drug reactions each year. Another 50,000 or so are hospitalized for treatment of such reactions.<sup>1,2</sup>There may well be more than a million more whose reactions occur away from the hospital and who require no hospital treatment. Perhaps as many as one person of every six who seek medical attention has suffered from an allergic or suspected allergic reaction to a drug at some time. Although toxic reactions to drugs are much more common than allergic ones, the allergic reactions tend to occur capriciously and explosively, with little or no warning. A reaction can be suspected of being allergic rather than toxic if the offending drug has been used before without any problem, or (as in classic serum sickness) if the reaction did not occur for several days after the drug was first administered. Drug allergy can produce a number of clinical
Combination of meld and lactates predicts early death in patients treated by salvage tips for refractory variceal bleeding
Authors: Aurélie Walter, Marika Rudler, Pol Olivas, Lucile Moga, Eric Trépo, Marie-Angèle Robic, Isabelle Ollivier-Hourmand, Anna Baiges, Olivier Sutter, Charlotte Bouzbib, Jean Marie Peron, Vincent Le Pennec, Nathalie Ganne, Juan Carlos Garcia Pagan, Maxime Mallet, Metivier Sophie, Thong Dao, Dominique Thabut, Virginia Hernandez-Gea, Jean Charles Nault, Christophe Bureau, Manon Allaire
Journal: Journal of Hepatology (2020)
Electric Stimulation in Morgagni-Adams-Stokes Disease
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Johannes Evangelista Purkynĕ
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Viral Hepatitis
Authors: Eddy D. Palmer
Journal: JAMA (1978)

Burgeoning information on the etiology of viral hepatitis has led to a series of review articles and monographs during the past five years, and, no doubt, the future will bring many more. The special importance of this book is that it brings together current understandings without including all the uncertainties, arguments, and infightings that have characterized some recent reviews. We have simply reached the point where current understandings seem reliable enough to make the history of how we got there less important than formerly. This book is brief and to the point. I did not become aware of any objectionable prejudice in the views of the authors. The authors cover virologic matters in detail but in surprisingly few words. There is an especially helpful chapter on epidemiology. Clinical aspects are described briefly. Chapters on fulminant hepatitis and chronic hepatitis are excellent, with useful discussions of clinical management. The six pages
Rheumatic Disease and Tonsillectomy
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 2960: NCX4040, a nitric oxide (NO) donating form of aspirin as a potential treatment for prostate cancer
Authors: SOMAIAH CHINNAPAKA, Gnanasekar Munirathinam
Journal: Cancer Research (2019)

Abstract Nonsteroidal anti-inflammatory drugs (NSAIDs) have been shown to be beneficial in preventing various types of cancers including prostate cancer (PCa). Of all the NSAIDs in use, Aspirin appears to be one of the promising anticancer agents for PCa management. However, experimental and epidemiological studies indicated that larger doses of Aspirin and long term supplementation is required to achieve anticancer effect with accompanied side effects. Therefore, our study focused on evaluating Aspirin derivative, namely NCX4040 which is a NO releasing form of Aspirin as a potent alternative for PCa treatment while minimizing the side effects. In the present study, we assessed the anticancer effects of NCX4040 on PC-3, a bone metastatic PCa cell line employing various in-vitro cellular assays. In our preliminary studies, we compared the effects of NCX4040 with that of Aspirin and NO releasing compound DETA/NO on PC-3 cells using MTT as read out. These results showed that NCX4040 is highly potent in inhibiting the viability of PC-3 cells when compared to Aspirin or DETA/NO treatments. Hence, further studies were focused on characterizing the anticancer properties as well as the underlying anticancer mechanism of NCX4040. Of note, our results showed that NCX4040 robustly inhibited the colony forming ability of PC-3 cells in-vitro implicating its antitumorigenic potential. In addition to inhibiting colony formation of PC-3 cells, NCX4040 also suppressed the Transwell matrigel invasion of PC-3 cells suggesting the antimetastatic effects of NCX4040. The observed antimetastatic effect of NCX4040 in PC-3 PCa cells appears to be via targeting actin cytoskeleton as confirmed by confocal microscopic analysis using phalloidin stain. Following these findings, we performed cell cycle analysis to determine whether NCX4040 enforces cell cycle arrest in PC-3 cells. These results showed that NCX4040 induced robust G0 cell cycle arrest in a dose dependent manner. Moreover, flow cytometry analysis using Annexin V and PI staining revealed that NCX4040 induced potent apoptotic cell death in PC-3 cells. To delineate the underlying anticancer mechanism of NCX4040, PC-3 cells treated with NCX4040 was subjected to apoptotic protein array analysis. Results of this study inferred that NCX4040 down regulated the expression of key anti-apoptotic proteins such as Survivin, XIAP and IAPs. In conclusion, our study suggests that NCX4040 is a promising alternative agent for PCa treatment. Citation Format: SOMAIAH CHINNAPAKA, Gnanasekar Munirathinam. NCX4040, a nitric oxide (NO) donating form of aspirin as a potential treatment for prostate cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2960.
The self-reporting of cocaine use
Authors: J. Rich
Journal: JAMA (1992)

<h3>In Reply.</h3> —Drs Gleason and Barnum's references indicate that gas chromatography/mass spectrometry identifies cocaine use in patients who have negative EMIT cocaine metabolite assays, the assay used by us as our criterion standard. Using these data and the figures from our article, they have calculated the prevalence of cocaine use in our population to be an astonishingly high 51%. We agree that our prevalence rate was only a minimum estimate of recent cocaine use and appreciate his point that actual prevalence may be even higher. Dr Holland suggests a creative design to ensure informed consent and to address the question of how foreknowledge of urine testing would affect questionnaire responses. However, urine screening information based on those subjects who consent to urine testing is not easily extrapolated to those subjects who refuse consent for urine testing. Moreover, as Holland points out, analysis based on missing data can only approximate true
Effect of physical activity trackers and daily text messages on quality-of-life in colorectal survivors (Smart Pace): A pilot randomized controlled trial.
Authors: Hilary Chan, Katherine Van Loon, Stacey A. Kenfield, June M. Chan, Emily Mitchell, Li Zhang, Alan T Paciorek, Galen Joseph, Angela Laffan, Yoshimi Fukuoka, Christine Miaskowski, Jeffrey A. Meyerhardt, Alan P. Venook, Erin Van Blarigan
Journal: Journal of Clinical Oncology (2018)

168 Background: There are over 1.3 million colorectal cancer (CRC) survivors in the United States, and many of whom suffer from lower health-related quality-of-life (HRQoL) years after diagnosis and treatment. Physical activity may improve survival outcomes and HRQoL for CRC survivors. Feasible interventions to support physical activity after CRC diagnosis are needed. Methods: We conducted a two-arm randomized controlled trial of 41 men and women who had completed treatment for CRC. Participants in the intervention arm were given a Fitbit Flex™ and received daily text messages for 12 weeks. HRQoL was assessed in both arms at baseline and 12 weeks using the RAND Short Form Survey (SF-36) and the Functional Assessment of Cancer Treatment – Colorectal (FACT-C). Survey score changes from baseline to 12 weeks were compared between the two arms using independent t-tests, and scores at baseline and 12 weeks were compared using paired t-tests. SAS was used for analysis, and statistical significance was declared at p &lt; 0.05. Results: We observed a statistically significant increase in the FACT-C functional well-being sub-scale in individuals in the intervention arm pre- and post- intervention (mean ∆ 1.81 ± 2.76; p: 0.02). There was no change in functional well-being in the control arm (mean ∆ -0.35 ± 4.12; p: 0.71). The between-arm comparison of change from baseline to 12 weeks was not statistically significantly ( p: 0.08). There was a statistically significant increase in the FACT-C emotional well-being sub-scale in the control arm (mean ∆ 1.20 ± 2.48; p: 0.04) and in the SF-36 role physical sub-scale in the control arm (mean ∆ 22.5 ± 38.8; p: 0.02). No other measures of HRQoL were statistically significantly different within groups, across time points, or between groups. Conclusions: A 12-week physical activity intervention using a Fitbit Flex and daily text messages may improve functional well-being among CRC survivors. Larger randomized studies are needed to definitively determine if a digital physical activity intervention improves functional well-being among CRC survivors, and if the improvement can be sustained over time. Clinical trial information: NCT02966054.
Durability of treatment response after 1 year of therapy with seladelpar in patients with primary biliary cholangitis (PBC): final results of an international phase 2 study
Authors: Cynthia Levy, Christopher Bowlus, Guy Neff, Mark G. Swain, Galambos Michael, Marlyn J. Mayo, Aparna Goel, Palak Trivedi, Gideon Hirschfield, Richard Aspinall, Andreas E. Kremer, Stuart C. Gordon, Brian Borg, Stephen Harrison, David Jones, Paul Thuluvath, Yvonne Doerffel, Carmen Stanca, David Sheridan, Bruce Bacon, Christoph Berg, Douglas Thorburn, John Vierling, Mitchell Shiffman, Joseph Odin, Tarek Hassanein, Adam Peyton, Aliya Gulamhusein, Charles Landis, David Bernstein, Lynsey Corless, Marcus-Alexander Woerns, Peter Buggisch, Sandrin Bergheanu, Wendy Chen, Frances Seput-Dingle, Lily Mao, Yu Li, Ke Yang, Elena Muslimova, Yun-Jung Choi, Monika Varga, Klara Dickinson, Pol Boudes, Charles McWherter, Alexandra (Sasha) Steinberg
Journal: Journal of Hepatology (2020)
Book Review Harrison's on CD-ROM 13th edition. CD-ROM with manual, 58 pp. Edited by Kurt J. Isselbacher, Joseph B. Martin, Eugene Braunwald, Anthony S. Fauci, Jean D. Wilson, and Dennis L. Kasper. System needed: IBM PC or compatible computer with a CD-ROM drive, and at least 2 megabytes available hard-disk space, 4 megabytes RAM, and Windows version 3.0 or higher. (Also available for Macintosh systems.) New York, McGraw-Hill, 1995. $195. 0-07-026896-7 Harrison's Plus: Harrison's on CD-ROM …
Authors: Eytan Z. Blumenthal, Daniel Mimouni
Journal: New England Journal of Medicine (1995)
Authors’ Reply
Authors: Peter. P. Reese, Olivier Aubert, Alexandre Loupy
Journal: Journal of the American Society of Nephrology (2021)

Husain and Mohan request clarification about our cohort study of biopsies to determine organ quality during kidney allocation.[1][1] Many donated kidneys in the United States undergo biopsy, and abnormal histology is a leading reason for subsequent organ discard. Fortunately, international variation
Causal Inference
Authors: Howard M. Staniloff
Journal: JAMA (1989)

This book is difficult for a clinician to follow, from both a structural and a content perspective. At the Society of Epidemiologic Research meeting in June 1985, Kenneth Rothman organized a symposium on the philosophical aspects of causal inference. This book presents four essays representing the four talks presented at that symposium. In addition, these essays are followed by seven commentaries by other authorities representing different backgrounds. The final section is a rebuttal from the original four authors. The content is centered on the opinions of Karl Popper on causal inference and how these opinions interact with more orthodox ones, such as those of Hill. The authors predominantly are proponents or antagonists of Popper's opinions. As such, the title of this book is misleading, since the text is a pseudodebate of one person's opinions rather than an equal presentation of most of the aspects of this area. The authors also
Observations on Strokes and Cerebral Edema With Intracranial Tumors
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Periodic physician recredentialing
Authors: A. Gellhorn
Journal: JAMA (1991)

The quality of health care services is a major concern of consumers and commands attention in the national health policy debate. The government and business emphasize quality medical care for its immediate relevance to cost containment. Federal legislation has been introduced requiring physician recertification, 19 of 23 specialty boards are requiring periodic recertification, and it has been proposed that reimbursement for physician services be contingent on compliance with standards of medical care. In the past 3 years, planning has been in progress in New York State to implement periodic physician recredentialing for medical relicensure. The current plan emphasizes peer review of guidelines developed by specialty societies and proposes educational enhancement, not loss of license, if a need to correct deficiencies is identified. (<i>JAMA</i>. 1991;265:752-755)
Encyclopedia of Chemical Technology. Volume 7: Furnaces to Iolite
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal