tbuckley/cabot-search huggingface dataset:
Operation for Obstructive Coronary Disease
Authors: G. M. FitzGibbon, G. D. Hopper, D. A. Maciver
Journal: BMJ (1969)

MEDICOHRNAL 181 heparin in clearing veins of fresh thrombus."It is true that suggestive evidence from several small series of cases has been published, but demonstration of superiority requires large-scale controlled trials, which have not been reported.Failure to mention urokinase is to be regretted.This plasminogen activator is of human origin; it is non-antigenic and relatively non-toxic.It is probably much easier with urokinase to obtain the type of biochemical state found by Johnson and McCarty' to be most effective in producing thrombolysis in man.Your leader's penultimate paragraph states "Now that the dose, route, control, and efficacy of thrombolytic therapy are becoming firmly established, this form of treatment should be part of the therapeutic armamen- tarium of all physicians and surgeons."We believe this enthusiastic advocacy to be premature, uncritical, and unjustified on currently available evidence.We regret that you have lent the weight of your authority to this advice.Dosage and control of therapy are controversial, and claims for proof of efficacy rest on clinical trial of inadequate design or of small scale; hazards and com- plications are still numerous.We believe that thrombolytic therapy may have great promise, but it must be regarded as still in the clinical investigative phase.Despite the many difficulties as discussed above, it is hoped that large-scale controlled clinical trials may soon be executed on an inter- national basis or on a national basis in this country, perhaps organized by a body such as the Medical Research Council.-We are, etc.,
β‐Thalassaemia in Cubans: Novel allele increases the genetic diversity at the HBB locus in the Caribbean
Authors: Adriana Muñiz, Gisela Martinez, João Lavinha, Paula Pacheco
Journal: American Journal of Hematology (2000)

In order to establish the molecular basis of β-thalassaemia in Cubans, a total of 75 unrelated individuals, with β-thalassaemia major (7), Hb S-β-thalassaemia (28), Hb C-β-thalassaemia (1), and β-thalassaemia trait (39) yielding 82 β-thalassaemia alleles, were analyzed. Seventeen different point mutations were identified accounting for 93% of the β-thalassaemia alleles studied, revealing a high genetic heterogeneity at the HBB locus in this population. The more prevalent mutations, namely, CD 39 (C → T) (30.5%), −29 (A → G) (13.4%), IVS-I-110 (G → A) (8.5%), and IVS-II-1 (G → A) (8.5%), reflect the Mediterranean and African predominant ancestry of the extant Cuban population. We also report the identification of a novel allele, IVS-I-108 (T → C), that possibly activates a cryptic branch site, in a β-thalassaemia carrier with no other molecular defect within the β-globin gene and its proximal promoter. This study shows that prenatal diagnosis of β-thalassaemia should be feasible in about 60% of at-risk pregnancies by direct detection of selected point mutations. However, due to the wide spectrum of mutations, and in order to offer fully informative prenatal diagnosis to more than 87% of at-risk couples, the screening for β-thalassaemia mutations in Cubans should be performed by using a general point mutation detection method, such as DGGE (denaturing gradient gel electrophoresis). Am. J. Hematol. 64:7–14, 2000. © 2000 Wiley-Liss, Inc.
Medical Schools in Canada
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mr. Gladstone on the Physician's Recompense.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Chirurgische Operationslehre für Studierende und ärzte.
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Accredited Sponsors of Continuing Medical Education
Journal: JAMA (1977)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
STEADY WEIGHT
Authors: MAURICE C. PINCOFFS
Journal: Annals of Internal Medicine (1954)

Editorial1 May 1954STEADY WEIGHTMAURICE C. PINCOFFSMAURICE C. PINCOFFSSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-40-5-1049 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptBecause of clinical interest in overweight and underweight patients and in the factors operative in producing such conditions, physicians are apt to devote little attention to the tantalizing problem of how it comes to pass that many normal adults unconsciously regulate their food intake so that they remain within a few pounds of the same weight often for 10 or more years at a stretch.Those persons best exhibiting this remarkable example of homeostasis are usually adults in the middle third of the normal life term. They are also apt to be settled people whose habitat has not altered climatically,...1 : Ideal weights, Metropolitan Life Ins. Bull. 23: 6, 1943, and 24: 6, 1943. Google Scholar2 CannonWashburn WBAS: An explanation of hunger, Am. J. Physiol. 29: 441-454, 1912. CrossrefGoogle Scholar3 Carlson AJ: Control of hunger in health and disease, 2nd impression, 1916, University of Chicago Press, Chicago, Ill. Google Scholar4 HetheringtonRanson AWSW: Hypothalamic lesions and adiposity in the rat, Anat. Rec. 78: 149-172, 1940. CrossrefGoogle Scholar5 MillerBaileyStevenson NECJJA: Decreased "hunger" but increased food intake resulting from hypothalamic lesions, Science 112: 256-259, 1950. CrossrefMedlineGoogle Scholar6 AnandBrobeck BKJR: Localization of "feeding center" in hypothalamus of rat, Yale J. Biol. and Med. 24: 141, 1951. Google Scholar7 Mayer J: Genetic, traumatic and environmental factors in the etiology of obesity, Physiol. Rev. 33: 472-508 (Oct.) 1953. CrossrefMedlineGoogle Scholar8 Brobeck JR: Food intake as a mechanism of temperature regulation, Yale. J. Biol. and Med. 20: 545-552, 1948. MedlineGoogle Scholar9 Brobeck JR: Physiology of appetite, in Overeating, overweight and obesity, Proceedings of the Nutrition Symposium held at the Harvard School of Public Health, Boston, Massachusetts, October 29, 1952, 1953, The National Vitamin Foundation, Incorporated, New York. Google Scholar10 BoothStrang GJM: Changes in temperature of the skin following the ingestion of food, Arch. Int. Med. 57: 533-543, 1936. CrossrefGoogle Scholar11 MayerGreenberg JRM: Hyperthemia in hypothalamic hyperplagia, Am. J. Physiol. 173: 523, 1953. CrossrefMedlineGoogle Scholar12 BeaudoinVan ItallieMayer RTBJ: Carbohydrate metabolism in "active" and "static" human obesity, J. Clin. Nutrition 1: 91-99 (Jan.) 1953. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1954Volume 40, Issue 5Page: 1049-1053KeywordsEatingOverweight Issue Published: 1 May 1954 PDF downloadLoading ...
Arterial oxygenation. Findings and its significance in central nervous system trauma patients
Authors: R. P. Sinha
Journal: JAMA (1973)

Arterial oxygenation was studied in a control group as well as in patients with head and spinal cord injuries. While most of the control group had normal partial arterial oxygen pressure (Pao<sub>2</sub>), half of the group with trauma had Pao<sub>2</sub>values below 80 mm Hg, and between 10% and 20% were significantly hypoxemic with Pao<sub>2</sub>values below 60 mm Hg. Since the clinical recognition of hypoxemia is exceedingly difficult unless there is a profound fall in Pao<sub>2</sub>, and since hypoxemia may be present almost immediately after the injury, the patient's Pao<sub>2</sub>should be determined in all cases of head and spinal cord injuries in order to institute proper therapy early.
Breakthrough during recombinant interferon alfa therapy in patients with chronic hepatitis C virus infection: Prevalence, etiology, and management
Authors: Luigi Roffi, Guido Colloredo Mels, Guido Antonelli, Giorgio Bellati, Fabio Panizzuti, Alberto Piperno, Massimo Pozzi, Davide Ravizza, Giovanni Angeli, Ferdinando Dianzani, Giuseppe Mancia
Journal: Hepatology (1995)

Recombinant interferon alfa (r-IFNα2) has been shown to normalize the aminotransferase levels in approximately 50% of patients with chronic hepatitis C virus (HCV). Few patients experience a relapse during the treatment, in spite of a complete initial response (breakthrough). We studied 191 HCV Ab-positive patients with histologically proven chronic hepatitis. All of them were treated with r-IFNα2 (3 MU three times a week). A complete response was seen in 54.4%. However, 12 of 104 responders experienced a breakthrough. At the time of breakthrough, neutralizing IFN antibodies were positive in 6 of 12 patients. Binding IFN antibodies were positive in all of these 12 patients. Continued treatment with r-IFNα2, even at higher doses, did not restore the previous response in any patient. All of them were then switched to natural lymphoblastoid IFN, and this rapidly restored a complete response in all of the patients.
Frozen Sections
Authors: Donald B. Polan
Journal: JAMA (1985)

<h3>To the Editor.—</h3> Dr Kindschi<sup>1</sup>certainly made the diagnosis with 100% accuracy on "Frozen Sections: Their Use and Abuse." Many others besides myself have documented the similar use and abuse of frozen sections. All surgeons should be required to read and initial the article prior to ordering their next frozen section.
The Doctor and His Patients: The American Domestic Scene as Viewed by the Family Doctor
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Calcineurin/Nfat signaling is required for perinatal lung maturation and function
Authors: V. Dave
Journal: Journal of Clinical Investigation (2006)

Pulmonary surfactant proteins and lipids are required for lung function after birth. Lung immaturity and resultant surfactant deficiency cause respiratory distress syndrome, a common disorder contributing to morbidity and mortality in preterm infants. Surfactant synthesis increases prior to birth in association with formation of the alveoli that mediate efficient gas exchange. To identify mechanisms controlling perinatal lung maturation, the Calcineurin b1 (Cnb1) gene was deleted in the respiratory epithelium of the fetal mouse. Deletion of Cnb1 caused respiratory failure after birth and inhibited the structural maturation of the peripheral lung. Synthesis of surfactant and a lamellar body–associated protein, ABC transporter A3 (ABCA3), was decreased prior to birth. Nuclear factor of activated T cells (Nfat) calcineurin-dependent 3 (Nfatc3), a transcription factor modulated by calcineurin, was identified as a direct activator of Sftpa, Sftpb, Sftpc, Abca3, Foxa1, and Foxa2 genes. The calcineurin/Nfat pathway controls the morphologic maturation of lungs prior to birth and regulates expression of genes involved in surfactant homeostasis that are critical for adaptation to air breathing.
Outcomes of Patients with POEMS Syndrome Treated Initially with Radiation
Authors: Michael Humeniuk, Morie A. Gertz, Martha Q. Lacy, Robert A. Kyle, Suzanne R. Hayman, Shaji K. Kumar, John A. Lust, Thomas E. Witzig, Francis K. Buadi, S. Vincent Rajkumar, Steven R. Zeldenrust, Stephen J. Russell, David Dingli, Yi Lin, Prashant Kapoor, Nelson Leung, Angela Dispenzieri
Journal: Blood (2012)
Department of Error
Authors: Tetsuya Tanimoto, Akihiko Ozaki, Kayo Harada, Yuta Tani, Masahiro Kami
Journal: The Lancet (2018)

Although these individuals had no previous problematic behaviour or criminal record, some played a crucial criminal part in the cult, justifying the murderous activity to save the souls of victims in preparation for reincarnation.Involvement of doctors is also seen in other terrorist organisations, such as Islamic State in Iraq and Syria. 4 Even educated doctors in an affluent country, and especially those that face discrimination in their ordinary lives, are not immune to the allure of such an organisation that advertises pursuit of pure life and identity.Young medical students and doctors might be particularly susceptible to spiritual doctrine and, in the case of Aum Shinrikyo, were brainwashed over a short period.To prevent future biochemical terror ism that involves medical experts will be a challenging task, but medical education could include lessons learned from Japan's experience, which should be shared among the world wide medical community.Japan also remains one of several developed countries that executes criminals. 5Japanese citizens should galvanise discussions about whether capital punishment is needed.
Comparison of endoscopic submucosal dissection with laparoscopic-assisted colorectal surgery for early-stage colorectal cancer: a retrospective analysis
Authors: S. Kiriyama, Y. Saito, S. Yamamoto, R. Soetikno, T. Matsuda, T. Nakajima, H. Kuwano
Journal: Endoscopy (2013)

Correction to: Comparison of endoscopic submucosal dissection with laparoscopic-assisted colorectal surgery for early-stage colorectal cancer: a retrospective analysisEndoscopy 2012; 44(11): 1024-1030DOI: 10.1055/s-0032-1310259
Involvement of Protein Kinase C, Phospholipase C, and Protein Tyrosine Kinase Pathways in Oxygen Radical Generation by Asbestos-Stimulated Alveolar Macrophage
Authors: Young Lim, Sun-Hyung Kim, Kyoung-Ah Kim, Min-Wha Oh, Kweon-Haeng Lee
Journal: Environmental Health Perspectives (1997)

Although asbestos stimulates oxygen radical generation in alveolar macrophages, the exact mechanism is still not clear.The purpose of this study was to compare the ability of three asbestos fibers (amosite, chrysotile, and crocidolite) to generate oxygen radicals in macrophages and examine the mechanism of this action.All asbestos fibers were able to induce chemiluminescence but chrysotile induced maximal chemiluminescence at higher concentrations than amosite and crocidolite.Protein kinase C (PKC) inhibitors (sphingosine and staurosporine) suppressed the ability of asbestos to induce oxygen radical generation.Phospholipase C (PLC) inhibitors (U73122 and neomycin) and protein tyrosine kinase (PTK) inhibitors (erbstatin and genistein) decreased oxygen radical generation of asbestos-stimulated alveolar macrophages.Oxygen radical generation was not suppressed by an adenylate cyclase activator (forskolin), a protein kinase A inhibitor (H-8), and a protein serine-threonine phosphatase inhibitor (okadaic acid).PLC and PTK inhibitors suppressed the increment of phosphoinositide turnover by amosite.These results suggest that asbestos fibers induce the generation of oxygen radicals through PTK, PLC, and PKC pathways in a dose-response pattern.
Human plague in the United States, 1900-1966
Authors: J. L. Caten
Journal: JAMA (1968)

One or two cases of human plague occur on the average in the United States each year. The occurrence of seven cases in 1965 and five in 1966 led to this review of the available records. A total of 547 cases of human plague with 349 deaths was reported in the continental United States from 1900 to 1966. Epidemics, following epizootics in urban rats, account for 432 of the cases with 284 deaths, all prior to 1925. From 1908 to 1966, contact with wild-rodent sources caused an additional 115 cases with 65 deaths.
DIABETIC NEUROPATHY
Journal: JAMA (1960)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Book Review Savill's System of Clinical Medicine . Eleventh edition. Edited by Agnes Savill, M.D. and E. C. Warner, M.D., F.R.C.P. 8°, cloth, 1141 pp., with 184 illustrations, 6 colored plates and 44 tables. Baltimore: William Wood &amp; Company, 1939. $9.00.
Journal: New England Journal of Medicine (1940)
Sidney Farber Medical Research Award, 1974
Journal: JNCI Journal of the National Cancer Institute (1974)

Journal Article Sidney Farber Medical Research Award, 1974 Get access JNCI: Journal of the National Cancer Institute, Volume 53, Issue 6, December 1974, Page 1881, https://doi.org/10.1093/jnci/53.6.1881 Published: 01 December 1974