tbuckley/cabot-search huggingface dataset:
Access to recombinant erythropoietin by Medicare-entitled dialysis patients in the first year after FDA approval
Authors: N. R. Powe
Journal: JAMA (1992)

<h3>Objective.</h3> —Examine access to recombinant human erythropoietin (rHuEPO) by dialysis-dependent end-stage renal disease (ESRD) patients during the first year after FDA approval for use in clinical practice and Medicare coverage. <h3>Design.</h3> —Longitudinal and cross-sectional claims data analyses. <h3>Setting.</h3> —All US providers of outpatient dialysis treatment. <h3>Patients.</h3> —126201 Medicare-entitled dialysis patients (≈93% of all US dialysis patients). <h3>Outcome Measures.</h3> —Percentage of patients who received rHuEPO, odds of receiving rHuEPO according to patient characteristics, and cost of rHuEPO to Medicare. <h3>Results.</h3> —One year after FDA approval, 52% of all dialysis and 60% of in-center hemodialysis patients who regularly had Medicare-paid dialysis services received rHuEPO at a monthly cost to Medicare of $19 million (18% of Medicare ESRD outpatient expenditures and 6% of all ESRD program expenditures). Blacks were less likely than whites to receive rHuEPO (odds ratio, 0.88; 95% confidence interval, 0.86 to 0.91). Home peritoneal and hemodialysis patients were less likely than in-center hemodialysis patients to receive rHuEPO (odds ratios, 0.17 and 0.22, respectively; 95% confidence intervals, 0.16 to 0.17 and 0.20 to 0.24, respectively). Use of rHuEPO varied across geographic regions. The odds of receiving rHuEPO were lower for patients of male vs female sex, of ages 35 through 64 years vs less than 35 years and greater than 65 years, with a longer history of ESRD, with polycystic kidney disease vs other causes of ESRD, and receiving care in nonprofit vs for-profit facilities. First-month hematocrits were slightly higher (1.2 percentage points) for patients starting rHuEPO in the 12th month than in the first month after FDA approval. <h3>Conclusions.</h3> —With prompt insurance coverage, the majority of Medicare-entitled dialysis patients received rHuEPO following widespread availability. Factors that may not be related to clinical need (race, setting of care, and geography) possibly influenced early patient access. More attention should be paid to monitoring the appropriate use of high-cost biotechnologic therapy. (<i>JAMA</i>. 1992;268:1434-1440)
Canadian Medical Association Journal, Toronto
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Incorrect Statement.
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Syncope
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AN OSTEOPATHY CONSPIRACY.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ERADICATING BOVINE TUBERCULOSIS
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Oesophageal epithelial ASIC3 is associated with increase in severity of symptoms in patients with gastro-oesophageal reflux disease (GORD)
Authors: Y. C. Chua, A. Hubball, M. Peiris, K. S. Ng, S. F. Hughes, J. Chinaleong, S. Preston, B. Patel, A. Chaudry, P. Levey, J. Martin, Q. Aziz, C. H. Knowles
Journal: Gut (2011)

<h3>Introduction</h3> Immunoreactive nerves and epithelial markers have been studied in the context of acid induced oesophageal hypersensitivity. Increase in immunoreactive TRPV1 nerves are associated with presence of oesophagitis12 as well as acid exposure time.3 ASIC3 was identified in epithelium of rat oesophagus and ASIC inhibitor (Amitidine) prevented oesophageal hyperaemic response in rats to CO2 infusion (mimicking acid).4 We aim to identify ASIC 3 in human oesophageal epithelium and to determine if it is a suitable biomarker of symptom severity in patients with gastro-oesophageal reflux disease (GORD). <h3>Methods</h3> 36 oesophageal mucosal biopsy samples from patients (age 19–59 years and 17 females) with or without GORD undergoing gastroscopy were obtained and their clinical symptoms were assessed using visual analogue scale (VAS) adapted from validated questionnaire ReQUEST. The symptoms assessed were; general feeling, acid complaints, upper abdominal complaints, lower abdominal complaints, nausea, sleep disturbances. Samples were paraffin fixed and analysed using immunohistochemistry for PGP 9.5 and ASIC3. <h3>Results</h3> Epithelial ASIC3 was identified in the mucosal biopsies (14 controls, 18 non-erosive reflux disease, 4 erosive oesophagitis). ASIC3 could be classified based on distribution and morphology into 4 groups; basal layer (stratum basale), stratum spinosum perinuclear, stratum spinosum membrane bound and superficial luminal layer staining. Patients who scored higher on VAS for all 6 symptoms also demonstrated higher expression of all 4 ASIC3 features studied (median 65% (35–87) vs 57% (34–79), p=0.018). In particular, for acid complaints, sleep disturbance and lower GI complaints, this association was more significant (median 64% (46–81) vs 54% (38–69), p=0.002). Nerve fibres as stained by PGP 9.5 in human oesophageal epithelium were absent. <h3>Conclusion</h3> Presence of specific epithelial ASIC3 features in oesophageal epithelium was associated with increase in severity of common GORD symptoms. Further quantitative studies are required to study correlation of ASIC3 as an objective biomarker of symptom severity.
DEATHS
Journal: JAMA (1961)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Heberden Society
Journal: Annals of the Rheumatic Diseases (1963)

A further booklet for patients was being prepared Annals of the Rheumatic Diseases.dealing with the diseases of the cervical and lumbar disks.Commonwealth The Heberden Society's membership had con- A full report of the autonomous affiliated Asso- tinued to grow.Regular meetings had been held ciations in Canada, Australia, and New Zealand throughout the year and had been reported in the is included in the Annual Report.HEBERDEN SOCIETY Clinical Meeting.-At a meeting held on Feb- ruary 8, 1963, at St. Stephen's Hospital, Fulham, the following communications were presented:Haemoglobin Levels in Rheumatoid Arthritis.By F. B. GIBBERD (Westminster Hospital): The haemoglobin levels of 533 patients with classical rheumatoid arthritis were studied.The average haemoglobin levels of the 385 women fell during the course of their illness, while that of the 148 men remained relatively constant.Salicylates, phenylbutazone, and steroids did not affect the haemoglobin. 24per cent. of the men and 17 per cent. of the women in the series had dyspepsia, but the haemoglobin level in these patients did not differ from that in those who did not have dyspepsia.In anaemic patients oral iron produced a definite rise in the haemoglobin and this continued for up to 9 months.The final haemoglobin level after iron therapy was usually about 12-5 g. per cent.and was independent of the initial level.Increasing the dose of iron above 200 mg.per day did not produce a more rapid rise in the haemoglobin.The response to oral iron was best in the early years of the illness.Intravenous iron had a similar effect to oral iron.The lowest haemoglobin levels were found in the patients with the highest Waaler-Rose titres.The x ray appearances did not correlate with the haemoglobin levels.It was considered that drug treatment and dyspepsia were not causes of the anaemia found in rheumatoid arthritis.A haemoglobin level below 12-5 g. per cent.was often due to iron deficiency, but there must be some other factor, possibly the rheumatoid disease process itself, which causes the abnormally low haemoglobin levels in patients with rheumatoid arthritis.
NIMG-42. RECURRENT TUMOR AND TREATMENT-INDUCED EFFECTS HAVE DIFFERENT MR SIGNATURES IN CONTRAST ENHANCING AND NON-ENHANCING LESIONS OF HIGH-GRADE GLIOMAS
Authors: Julia Cluceru, Sarah Nelson, Annette Molinaro, Paula Alcaide-Leon, Marram Olson, Mitchel Berger, Susan Chang, Joanna Phillips, Devika Nair, Qiuting Wen, Javier Villanueva-Meyer, Pranathi Chunduru, Soonmee Cha, Janine Lupo
Journal: Neuro-Oncology (2019)

Abstract INTRODUCTION It is estimated that 25 to 35% of patients experience treatment-induced effects that can mimic recurrent high-grade gliomas. This diagnostic challenge is complicated by the coexistence of treatment-related changes and recurrent tumor within the same lesion which limits the accuracy of classification based on summary metrics of multi-parametric MRI. This study aimed to determine whether different MR features were relevant for distinguishing pathological features of recurrent tumor from the effects of treatment in the contrast enhancing and non-enhancing lesions of recurrent high-grade gliomas. METHODS Leveraging our unique dataset of image-guided tissue samples that directly maps pathology to MR characteristics, we analyzed 291 tissue samples (222 recurrent tumor; 69 treatment effect) with known coordinates on imaging from 139 patients that underwent preoperative 3T MRI and surgery for a suspected high-grade recurrent tumor. 8 MR parameter values from perfusion-weighted, diffusion-weighted, and MR spectroscopic imaging at each tissue sample location were tested for association with histopathological outcome using univariate and multivariate generalized estimating equation models for enhancing and non-enhancing tissue samples. Individual cutoff values were determined and evaluated using ROC-Curve analysis with 5-fold cross-validation. RESULTS In tissue samples obtained from contrast-enhancing lesions, elevated relative cerebral blood volume (rCBV) was significantly associated with the presence of recurrent tumor (p&lt; 0.03), while increases in normalized choline (nCho) and choline-to-NAA index (CNI) were significantly associated with the presence of recurrent tumor in non-enhancing tissue samples (p&lt; 0.008). Cutoff values of 1.6(rCBV), 2.7(CNI), and 2.1(nCho) had the highest performance. CONCLUSION Our results confirm the utility of rCBV in distinguishing the effects of treatment from recurrent tumor within the contrast enhancing lesion. We report a novel finding that metabolic parameters can differentiate recurrent tumor from treatment-related changes in the non-enhancing lesion of high-grade gliomas. These results will help improve future management of patients with suspected recurrence.
LINEAR LESIONS*
Authors: R. H. MACDONALD, R. T. SIMS
Journal: British Journal of Dermatology (1969)

Journal Article LINEAR LESIONS Get access R. H. MACDONALD, R. H. MACDONALD Department of Dermatology, Addenbrooke's Hospital, Cambridge and Department of Anatomy, Cambridge Search for other works by this author on: Oxford Academic Google Scholar R. T. SIMS R. T. SIMS Department of Dermatology, Addenbrooke's Hospital, Cambridge and Department of Anatomy, Cambridge Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 81, Issue s3, 1 June 1969, Pages 72–79, https://doi.org/10.1111/j.1365-2133.1969.tb12857.x Published: 01 June 1969
The effects of low dietary levels of polyunsaturates on alcohol-induced liver disease in rhesus monkeys
Authors: R Pawlosky
Journal: Hepatology (1997)

Rhesus monkeys that were maintained on a diet containing low, yet adequate, amounts of vitamins C and E and in which linoleate and linolenate represented 1.4% and 0.08% of the total caloric intake, respectively, developed liver fibrosis after consuming alcohol (mean, 2.6 g kg-1 d-1) over a period of 3 years. In the liver, several polyunsaturated fatty acids including 18:2n6, 20:4n6, and 22:6n3 decreased compared with dietary controls, and similar findings were also observed in plasma lipoproteins and erythrocytes. The amount of alcohol consumed correlated positively with plasma lipid peroxidation products, 4-hydroxynonenal (4-HNE) and 8-isoprostane F2α, and negatively with 20:4n6 and 22:6n3 levels. These findings imply that alcoholics who also have a marginal intake of essential fatty acids and antioxidants in their diets may be at an increased risk of developing liver disease.
Report Offers Vision For Microbicide Development
Authors: J. Stephenson
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Books Received
Journal: JNCI Journal of the National Cancer Institute (1972)

Journal Article Books Received Get access Biomedical Implications of Radio strontium Exposure. Springfield, Va., National Technical Information Service, $6.00. Ardenne M: Theoretische und experimentelle Grundlagen der Krebs-Mehrschritt Therapie (neoplasms and drug therapy). Berlin, Verlag Volk und Gesundheit, 1970–71, 2 v. (xlviii), 963 pp, $100.62. Bartko D: Serove a likvorove bielkoviny pri akutnej hypoxii a tumoroch mozgu (anoxemia and blood). Praha, Avicenum, 1971, 221 pp, $1.50. Bekkum DW: Lymphoid Cell Replacement Therapy. Copenhagen, Munsksgaard, c1972, 72 pp. British Association for Cancer Research: (Riggott JM, ed.). Hull, Eng., Dept. of Zoology, The University, c1971, 115 pp, $2.00. Bufano M: Simposio su il mieloma multiplo (multiple myeloma and congresses). Roma, Pozzi, 1971, 450 pp. Burnet FM: Immunological Surveillance Against Neoplasia. Copenhagen, Munsksgaard, 1971, 178 pp. Endocrine Therapy in Malignant Disease (Stoll BA, ed.). London, Philadelphia, Saunders, 1972, 442 pp, $23.00. Klishov AA: Gistogenez, regeneratsiia i opukholevyi rost skeletnomy-shechnoi tkani (neoplasms and muscle tissue). Leningrad, Meditsina, 1971, 174 pp, $2.00. Kozlova AV: Luchevaia terapiia zlokachestvennykh opukholei (neoplasms and radiotherapy). Moskva, Meditsina, 1971, 351 pp, $4.00. Lynch HT: Skin, Heredity, and Malignant Neoplasms. Flushing, N.Y., Medical Examination Pub. Co., 1972, 299 pp. Photofluorographic Diagnosis of Lung Cancer; Especially for Early Detection (Hayata Y, ed.). Tokyo, Igaku Shoin, 1971, 154 pp, $17.22. Romanini A: Elementi di tecnica telecobaltoterapica ad incidenza fissa dei tumori del capo e del collo (cobalt isotopes and therapeutic use). Milano, Vita e pensiero, 1968, 298 pp. Rummel HH: Der Dyskaryosebegriffund seine Bedeutung fur die cytologische differentialdiagnose und die Behandlung der Vorstadien und Fruhformen des Cervix-Karzinoms (carcinoma, epidermoid and diagnosis). Heidelberg, Huthig, 1972, 108 pp. Samuels LD: Cancer Diagnosis in Children. Cleveland, CRC Press, c1972, 131 pp, $25.00. Tumors of the Head and Neck (Kitamura T, ed.). Tokyo, Igaku Shoin, 1971, 483 pp, $55.19. Zinser HK: Mammakarzinoma; Diagnose und Differential-diagnose (breast neoplasms and diagnosis). Stuttgart, Thieme, 1972, 134 pp, $9.35. JNCI: Journal of the National Cancer Institute, Volume 49, Issue 4, October 1972, Page 1213, https://doi.org/10.1093/jnci/49.4.1213 Published: 01 October 1972
Conference on Carcinoma of the Large Bowel and its Precursors
Journal: JNCI Journal of the National Cancer Institute (1984)

Journal Article Conference on Carcinoma of the Large Bowel and its Precursors Get access JNCI: Journal of the National Cancer Institute, Volume 73, Issue 1, July 1984, Page 301, https://doi.org/10.1093/jnci/73.1.301-a Published: 01 July 1984