tbuckley/cabot-search huggingface dataset:
The Treatment of Infections with Penicillin
Authors: Donald G. Anderson
Journal: New England Journal of Medicine (1945)

Staphylococcal Infections Penicillin has proved to be the most effective chemotherapeutic agent yet discovered for the treatment of staphylococcal infections.55,56,62 The usual mortality rate of 80 per cent in untreated cases of staphylococcic bacteremia63 has been reduced with penicillin treatment to 20 per cent or even less. Doses between 150,000 and 300,000 units a day are usually desirable until the infection has been controlled. The daily dosage may then be reduced to 120,000 units. It has been widely recognized that in severe staphylococcal infections striking improvement may not be observed for several days after the beginning of treatment. It is . . .
Investigating hypophosphataemia
Authors: P. Glendenning, D. A. Bell, R. J. Clifton-Bligh
Journal: BMJ (2014)

This article discusses common and rare causes of hypophosphataemia, appropriate investigations, and when to refer for specialist opinion #### Learning points A 55 year old man with a squamous cell carcinoma of the head and neck was investigated before referral for chemotherapy. He was asymptomatic and not taking any drugs. Blood test results showed phosphate 0.7 mmol/L (reference limit 0.8-1.5) and total calcium 2.34 mmol/L (2.15-2.60). The concentration of circulating phosphate depends on intestinal absorption, renal handling, and skeletal storage, and consequently is regulated by parathyroid hormone, vitamin D, and fibroblast growth factor 23. Internal cellular redistribution of phosphate is also important and results in hypophosphataemia under specific circumstances. The box outlines the causes of hypophosphataemia, based on the physiological regulation of phosphate metabolism. #### Possible causes of hypophosphataemia ##### Extrarenal (common) ##### Renal
CLINICAL ANATOMY
Authors: W. J. Hamilton
Journal: BMJ (1961)

<h3>Introduction</h3> Perturbation-based balance training (PBT) is reported to effectively reduce falls in older adults and may even be superior compared with various exercise programmes. Due to the nature of the intervention, requiring unpredictable balance perturbations, the question arises whether acceptability is an issue in PBT. <h3>Objective</h3> To evaluate the acceptability of PBT in older adults with a recent history of falls. <h3>Design, method, participants and setting</h3> This is a qualitative study in which semistructured interviews were conducted in 16 older adults (14 women and 2 men, mean age 73.6±6.0 years) who completed a three-session PBT protocol as part of another study in a university medical centre in the Netherlands. Typical case and purposive sampling strategies were applied. Interviews were based on the theoretical framework of acceptability (TFA) alongside context-specific factors and analysed using a template analysis approach. <h3>Results</h3> The results indicate that this PBT protocol is perceived as acceptable by older adults with a recent history of falls and highlight key areas for potential future modifications. Enjoyment of the novel training and technology, being able to feel safe during training, and perceived impact of increased self-efficacy and balance confidence were identified as facilitating factors. Potential issues included initial apprehension or anxiety during training and perceived impact being predominantly psychological instead of physical. Complementary to the TFA one additional theme emerged which described challenges regarding the training setting, such as preference for group training in some participants and travel to the training location. <h3>Conclusions</h3> The results suggest that PBT is perceived acceptable by older adults with a history of falls. Increasing the social aspect of training and sharing the experiences of peers may be considered to enhance acceptability to new participants who initially feel apprehensive or anxious about their ability to participate in future implementation of PBT. <h3>Trial registration number</h3> The article is linked to a randomised clinical trial registered on https://www.trialregister.nl/trial/7680, NL7680; Results.
TERA TOLOGY
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
FROM WASHINGTON.
Journal: JAMA (1884)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Redundant publication in hepatology
Authors: M Yamauchi, Y Maezawa, Y Mizuhara, M Ohata, J Hirakawa, H Nakajima, G Toda
Journal: Hepatology (1996)

in Alcoholism: Clinical and Experimental Research. 4 The 80 patients with biopsy-proven alcoholic liver disease were not We are writing in response to your letter pointing out the always diagnosed as alcohol dependent by psychiatrists.existence of overlaps in content in our articles published in However, 62 of 80 patients and 60 healthy controls were used HEPATOLOGY 1 and the Journal of Hepatology. 2 The letter for analysis in the Alcoholism: Clinical and Experimental showed that we submitted the data to two different journals Research paper.The reference 4 had to be added in the two using the same materials while assuring each journal that journals.the material was not under consideration elsewhere.IndeedWe intend, in our individual ways, to ensure that an incithere are areas of duplication in the papers.We have to apolodent like this will not occur a second time.gize for this lapse of professional ethics.We read your previous editorial thoroughly. 3 We did not understand well enough the limits of the materials we could analyze.Although this MASAYOSHI YAMAUCHI, M.D.
Androgen conjugates: physiology and clinical significance
Authors: R. S. Rittmaster
Journal: Endocrine Reviews (1993)

HIRSUTISM in women is characterized by increased androgen production from the ovaries and/or adrenal glands and enhanced sensitivity of the skin to circulating androgens (1). Frequently these problems coexist. Serum levels of testosterone, androstenedione, and dehydroepiandrosterone sulfate (DHEAS) have been used as markers of overproduction of androgens or their precursors and are often elevated in hirsute women. It has been more difficult to find markers of skin sensitivity to androgens. Skin sensitivity to androgens is modulated by the enzyme 5α-reductase, which converts testosterone to dihydrotestosterone (DHT), the active androgen in the skin (2). Serum DHT levels, however, have not usually correlated with the presence or the degree of hirsutism. DHT is rapidly metabolized to other compounds, including androstanediol, androsterone, and their glucuronide and sulfate conjugates. Over the past decade, physiological and clinical studies have suggested that androstanediol glucuronide, and possibly other androgen conjugates, may be biochemical markers of cutaneous androgen metabolism and action. Other studies have suggested that these androgen conjugates arise primarily from adrenal precursors and may be a marker of adrenal hyperandrogenism. The purpose of this review is to critically appraise the data concerning the physiological significance of androgen conjugates and to address the following question: "Are androgen conjugates a reflection of cutaneous androgen metabolism or is their correlation with hirsutism an epiphenomenon caused by the overproduction of androgen precursors in hirsute women?"
Thymidylate synthase (TS) and methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms: Relationships with capecitabine (X) pharmacodynamics in advanced breast cancer (ABC) patients (pts)
Authors: R. Largillier, J. L. Formento, A. Ginot, M. C. Etienne, M. Francoual, N. Renée, J. M. Ferrero, C. Foa, M. Namer, G. Milano
Journal: Journal of Clinical Oncology (2004)

2062
Roentgenologic aspects of intrauterine transfusion
Authors: E. J. Ferris
Journal: JAMA (1966)

It is the purpose of this communication to consider the method of intrauterine infusion of red blood cells (RBCs) into the fetus with erythroblastosis fetalis. The roentgenologic aspects and inherent dangers encountered will be stressed. The indications for intrauterine infusion of RBCs into the fetus of a mother who is sensitized to the Rh antigen have been previously reported by Little,<sup>1</sup>and are similar to those reported by Liley,<sup>2</sup>McCrostie,<sup>3</sup>and Bowman.<sup>4</sup>It is not the purpose of this paper to review the indications for the procedure. Careful spectrophotometric amniotic-fluid values have been established and observed at our clinic at the Boston City Hospital.<sup>1</sup>The time of transfusion differs in our series of mothers, beginning in some cases as early as 24 weeks' gestation. The number of transfusions varies from one to three per patient in our group of mothers. <h3>Roentgenologic Aspects</h3> The technique has
Resident Forum
Authors: Andrew Basile
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Acta Neuropathologica, Berlin
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Atypical Coverage for Community-acquired Pneumonia
Authors: Forest W. Arnold, James T. Summersgill, Andrew S. LaJoie, Paula Peyrani, Thomas J. Marrie, Paolo Rossi, Francesco Blasi, Patricia Fernandez, Thomas M. File, Jordi Rello, Rosario Menendez, Carlos M. Luna, Julio A. Ramirez
Journal: American Journal of Respiratory and Critical Care Medicine (2007)
Postmaturity
Authors: J. C. McClure Browne
Journal: JAMA (1963)

There appears to be a marked relationship between pregnancies lasting longer than 40 weeks and perinatal mortality; toxemia aggravates this condition. Therefore, estimating the true duration of pregnancy is especially important and may be done in a number of ways at various stages of the pregnancy. There is evidence that the placenta has a limited life span and calcifies often in pregnancies past term, a sign indicative of forthcoming fetal death. The incidence of fetal distress and of operative delivery in labor has been shown statistically to increase in prolonged pregnancies. Induction of labor is recommended but should only be attempted if facilities for operative delivery are available, otherwise more babies will be lost as a result of interference than are saved by it.
Glucose Intolerance and Impaired Insulin Secretion in Pancreas-Specific Signal Transducer and Activator of Transcription-3 Knockout Mice Are Associated with Microvascular Alterations in the Pancreas
Authors: Elena Kostromina, Natalia Gustavsson, Xiaorui Wang, Chun-Yan Lim, George K. Radda, Cai Li, Weiping Han
Journal: Endocrine Reviews (2010)
THE FOURTH DISEASE (FILATOW-DUKES' DISEASE)?
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Phase III (COSMIC-312) study of cabozantinib (C) in combination with atezolizumab (A) vs sorafenib (S) in patients (pts) with advanced hepatocellular carcinoma (aHCC) who have not received previous systemic anticancer therapy
Authors: L. Rimassa, A.-L. Cheng, F. Braiteh, A. Chaudhry, F. Benzaghou, P. Thuluvath, S. Hazra, A.E. Borgman-Hagey, B. Tan, Z.K. Kayali, A.X. Zhu, R.K. Kelley
Journal: Annals of Oncology (2019)
Use of the hCONSORT criteria as a reporting standard for herbal interventions for common dermatoses: a systematic review
Authors: J. Ornelas, E. Routt, P. Kallis, H. Lev-Tov
Journal: British Journal of Dermatology (2018)

Summary Complementary and alternative medicine (CAM) has been increasing in popularity in western countries for various conditions, including those that affect the skin. Alternative medicine is defined as treatment approaches that are outside the realm of western medicine and complimentary medicine combines the use of such treatments with western medicine. Despite this increase in prevalence, western healthcare providers have not integrated CAM into their practice due to a lack of reliable scientific studies that support its use. One way to close the gap between prevalence of public use and lack of reliable data is to improve the way studies are reported in medical journals. In 2006 guidelines were published to help scientific researchers conduct quality research regarding the use of herbal medications. These guidelines were called the CONSORT extension criteria on reporting herbal interventions (hCONSORT) and were published in 2006. We wanted to examine how well these guidelines we adopted in dermatology. As part of our research, based in the U.S., we reviewed scientific studies that investigated the use of plant-based medications for the use of three common skin conditions: acne, atopic eczema, and psoriasis. We focused on articles published between 2009 and 2014 and graded their adherence to the hCONSORT guidelines. Surprisingly, we found that the majority of these scientific studies adhered to less than 50% of the hCONSORT guidelines. Based on these findings, we recommend that scientists adhere to these guidelines when conducting studies regarding the use of herbal medications and that editors of scientific journals encourage adherence to these guidelines when presented with articles that assess the use of herbal medications. Doing so will help western healthcare practitioners safely and effectively integrate CAM into conventional medicine.
2019 American College of Rheumatology/Arthritis Foundation Guideline for the Management of Osteoarthritis of the Hand, Hip, and Knee
Authors: Sharon L. Kolasinski, Tuhina Neogi, Marc C. Hochberg, Carol Oatis, Gordon Guyatt, Joel Block, Leigh Callahan, Cindy Copenhaver, Carole Dodge, David Felson, Kathleen Gellar, William F. Harvey, Gillian Hawker, Edward Herzig, C. Kent Kwoh, Amanda E. Nelson, Jonathan Samuels, Carla Scanzello, Daniel White, Barton Wise, Roy D. Altman, Dana DiRenzo, Joann Fontanarosa, Gina Giradi, Mariko Ishimori, Devyani Misra, Amit Aakash Shah, Anna K. Shmagel, Louise M. Thoma, Marat Turgunbaev, Amy S. Turner, James Reston
Journal: Arthritis & Rheumatology (2020)

To develop an evidence-based guideline for the comprehensive management of osteoarthritis (OA) as a collaboration between the American College of Rheumatology (ACR) and the Arthritis Foundation, updating the 2012 ACR recommendations for the management of hand, hip, and knee OA.We identified clinically relevant population, intervention, comparator, outcomes questions and critical outcomes in OA. A Literature Review Team performed a systematic literature review to summarize evidence supporting the benefits and harms of available educational, behavioral, psychosocial, physical, mind-body, and pharmacologic therapies for OA. Grading of Recommendations Assessment, Development and Evaluation methodology was used to rate the quality of the evidence. A Voting Panel, including rheumatologists, an internist, physical and occupational therapists, and patients, achieved consensus on the recommendations.Based on the available evidence, either strong or conditional recommendations were made for or against the approaches evaluated. Strong recommendations were made for exercise, weight loss in patients with knee and/or hip OA who are overweight or obese, self-efficacy and self-management programs, tai chi, cane use, hand orthoses for first carpometacarpal (CMC) joint OA, tibiofemoral bracing for tibiofemoral knee OA, topical nonsteroidal antiinflammatory drugs (NSAIDs) for knee OA, oral NSAIDs, and intraarticular glucocorticoid injections for knee OA. Conditional recommendations were made for balance exercises, yoga, cognitive behavioral therapy, kinesiotaping for first CMC OA, orthoses for hand joints other than the first CMC joint, patellofemoral bracing for patellofemoral knee OA, acupuncture, thermal modalities, radiofrequency ablation for knee OA, topical NSAIDs, intraarticular steroid injections and chondroitin sulfate for hand OA, topical capsaicin for knee OA, acetaminophen, duloxetine, and tramadol.This guideline provides direction for clinicians and patients making treatment decisions for the management of OA. Clinicians and patients should engage in shared decision-making that accounts for patients' values, preferences, and comorbidities. These recommendations should not be used to limit or deny access to therapies.
Index of Medicine. A Manual for the Use of Senior Students and Others.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal