tbuckley/cabot-search huggingface dataset:
Tufts uses grant to design programs for drawing medical students into primary care careers
Authors: A. A. Skolnick
Journal: JAMA (1993)

AS PART of an ambitious project to replenish the ranks of primary care physicians in the United States, the Robert Wood Johnson Foundation, Princeton, NJ, has chosen Tufts University School of Medicine, Boston, Mass, as one of 18 medical schools to receive a planning grant under the foundation's Generalist Physician Initiative. The $150 000, 18-month grant will be used by Tufts to design new programs aimed at encouraging students to choose a career in generalist medicine. Eighty-three medical schools had competed for the Robert Wood Johnson planning grants. In 1994, the foundation will choose 12 of the plans submitted by the 18 planning grant recipients. Each will receive approximately $2.5 million to implement their winning programs. It is hoped that these high-profile programs will serve as models and incentives for other schools to spur on a nationwide revival of interest in primary care medicine, says Morton A. Madoff, MD, MPH,
Measles — United States, 1988
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Opportunities and challenges of laboratory testing at alternative sites
Authors: C. R. Handorf
Journal: JAMA (1995)

A 15th-century woodcut portrays a physician making a house call at the bedside of his patient.<sup>1</sup>The physician's right hand is on the patient's pulse while he points with his left hand to a flask of the patient's urine held up to the light by an assistant. In observing the urine, the physician is practicing the art of uroscopy, that is, the attempted gleaning of knowledge of the patient's condition from the direct observation of fresh urine. The science of laboratory medicine advanced little from the 15th to the 19th century, whereupon the introduction of medical microscopy greatly advanced the ability of physicians to observe and diagnose patients. Scientific and technical advances accelerated in the 20th century, especially after World War II, with astonishing speed and breathtaking scientific elegance. These advances allowed a remarkable enhancement of the physician's ability to diagnose; however, they carried a price: the transfer of
Efficacy of bolus and infusional 5-FU in elderly and non-elderly patients with metastatic colorectal cancer - a pooled analysis of clinical trials
Authors: G. Folprecht, D. Cunningham, B. Glimelius, F. Dicostanzo, J. Wils, W. Scheithauer, P. Rougier, E. Aranda, U. Pabst, C. H. Köhne
Journal: Journal of Clinical Oncology (2004)

8045 Background: Recently published population-based investigations showed elderly patients to be underrepresented in clinical trials and less often treated according the standard therapy, although they benefit to the same extent from adjuvant (radio-) chemotherapy as younger patients. No large series describes the influence of age on efficacy of chemotherapy in metastatic colorectal cancer. Methods: We carried out a retrospective analysis using source data of 3,825 patients who received 5-FU containing treatment in 22 European trials and identified 629 patients with an age of ≥ 70 years. Results: An equal overall survival was observed in elderly patients (10.8 months, 95 % CI 9.7–11.8) and in younger patients (11.3 months, 95 % CI 10.9–11.7, p = .31). Response rate did not differ between the age groups ≥ 70 and < 70 years (20.8 % and 17.6 %, p = .14). Progression free survival was marginally prolonged in elderly patients (5.5 months, 95 % CI 5.2–5.8 and 5.3 months, 95 % CI 5.1–5.5, p = .01). In both age groups, infusional 5-FU resulted in significantly increased response rates, overall survival and progression free survival compared to bolus 5-FU. The Cox- regression analysis showed no influence of age on OS. Conclusions: We conclude that “fit” elderly patients (fulfilling standard inclusion criteria of clinical trials) benefit to the same extent from palliative chemotherapy with 5-FU. Infusional 5-FU is more effective in elderly as in younger patients. Standardized palliative chemotherapy should generally be offered to elderly patients and they should not be excluded from clinical trials. No significant financial relationships to disclose.
Evaluation of the contribution of individual gene groups to a 17-gene prognostic prostate cancer signature.
Authors: Dejan Knezevic, Ruixiao Lu, Emily Burke, Megan Rothney, Nan Zhang, H. Jeffrey Lawrence, Phillip G. Febbo
Journal: Journal of Clinical Oncology (2015)

5060 Background: A 17-gene biopsy-based RT-PCR assay (Oncotype DX® Prostate Assay) has been validated as a predictor of adverse pathology and biochemical recurrence (BCR) in clinically very low to intermediate-risk prostate cancer patients. The assay measures expression of 12 cancer and 5 reference genes that are combined to calculate a Genomic Prostate Score (GPS; scaled 0-100), providing a biologic measure of tumor aggressiveness. The cancer genes represent four biological pathways: androgen signaling, stromal response, cellular organization and proliferation. We examined the effects of variation in quantitative expression of individual gene groups on GPS results and prediction of clinical risk. Methods: The first 3,500 tumor specimens processed in the Genomic Health Inc.’s reference laboratory were included. Expression of individual genes was measured and the expression of the four gene groups and GPS calculated. For each gene group, GPS of patients with the lowest 5% expression levels were contrasted with GPS of patients with highest 5% expression levels. Results: Percentages of NCCN very low, low and intermediate patients were 28%, 37%, 30%; median age was 65. Mean and median GPS were 24.6 and 23 (range 0-90). Individual gene groups exhibited wide expression ranges (e.g. proliferation-16-fold difference (FD) vs. cellular organization > 8000 FD). Large differences in expression of each gene group were reflected in GPS values and, based on a prior clinical validation study, translate into large differences in BCR risk (Table). Conclusions: Each of the four gene groups show large variations in expression, meaningfully affect the GPS, and contribute to the prediction of PCa aggressiveness. Gene groups Median GPS for lowest 5% of expression (1st, 3rd quartiles) Predicted 5-year BCR Risk for median GPS for lowest 5% of expression [95% CI] Median GPS for highest 5% of expression (1st, 3rd quartiles) Predicted 5-year BCR Risk for median GPS for highest 5% of expression [95% CI] Stromal 12 (8, 19) 6% [3%, 10%] 43 (34, 53) 26% [20%, 33%] Cell Organization 37 (27, 46) 20% [ 15%, 25%] 21 (15, 27) 9% [6%, 13%] Androgen 50 (44, 58) 36% [27%, 46%] 9 (5, 13) 5% [3%, 9%] Proliferation 16 (11, 22) 7% [4%, 11%] 35 (26, 43) 18% [14%, 23%]
Correction: Haemangioma of the cord: a further cause of raised maternal serum and liquor alpha-fetoprotein
Authors: Jennifer Hughes
Journal: BMJ (1980)

patients with functional psychiatric illness in the absence of clinical evidence of physical disease or alcoholism.We are grateful to Dr P B Guyer and Dr K C Dewbury for help in reviewing the chest radiographs, and Mrs H Hills for helping to collect data.The table giving details of the 21 patients with relevant radiographic abnormalities may be obtained from Dr Jennifer Hughes.
News notes from neurology meeting
Journal: JAMA (1979)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The scientific community's response to evidence of fraudulent publication. The Robert Slutsky case
Authors: W. P. Whitely
Journal: JAMA (1994)

<h3>Objective.</h3> —To determine whether scientists can detect fraudulent results in published research articles and to identify corrective measures that are most effective in purging fraudulent results from the literature. <h3>Design.</h3> —Retrospective case-control study comparing articles by an author known to have published fraudulent articles, Robert A. Slutsky, MD, to a set of control articles. The number of non-self-citations received by each article during each calendar year (1979 through 1990) was counted. The citation numbers were transformed into scores. Each Slutsky article was assigned a score between 1 and 3 based on the number of citations received by the Slutsky article and each of its assigned control articles. Average citation numbers and scores were tracked for each year during the 11-year study period. <h3>Results.</h3> —Before Slutsky's work was publicly questioned (1975 to 1985), scientists cited his articles as frequently as they cited control articles. After Slutsky's work was questioned and reports were published in the news media (1985), scientists cited his articles less frequently than they cited control articles. Citations decreased further after the University of California—San Diego published a review of the validity of Slutsky's work in 1987. Citations did not decrease after the appearance of retractions in print or in MEDLINE. <h3>Conclusion.</h3> —Scientists do not, and probably cannot, identify published articles that are fraudulent. However, when alerted to the presence of fraudulent results in the literature, the scientific community responds by reducing the number of citations of the tainted articles. In the Slutsky case, general news articles and the three reviews published by the University of California—San Diego were most effective and retractions were least effective in purging fraudulent results from the literature. (<i>JAMA</i>. 1994;272:170-173)
Human Research
Authors: Louis Welt
Journal: New England Journal of Medicine (1972)

Dr. Altman's informative and provocative paper in this issue of the Journal is sprinkled with pertinent questions. This editorial will end with a question as well.In the meantime, the central issues that deal with human research, whether auto- or homo-experimentation, remain the same. Several criteria that should be met can be dealt with readily since the community of informed scientists and nonscientist citizens will probably agree. First of all, is the question that is raised for experimentation reasonable? (Reasonable is defined in the sense that the answer is both unknown and knowable.) Secondly, is the design of the experiment . . .
The Clinical Spectrum of Renal Tubular Acidosis
Authors: L. Rocher
Journal: Annual Review of Medicine (1986)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease 2019 (COVID-19), emerged in China in December 2019 and quickly spread around the globe, killing more than 4 million people and causing a severe economic crisis. ...Read More
Hemorrhage from gastroesophageal lacerations following closed-chest cardiac massage
Authors: G. D. Lundberg
Journal: JAMA (1967)

Five cases of acute hemorrhage of the upper-gastro-intestinal tract due to gastric and esophageal lacerations complicating closed-chest cardiac massage were observed by an autopsy service of a general teaching hospital over a 16-month period. During the same time, 348 autopsies were performed, including 50 patients who had received closed-chest cardiac massage. Fractured ribs were found in 20 patients (40%) while gastric and esophageal lacerations were the second most frequently encountered significant complication (10%). Prevention, early recognition, and prompt decompression of acute gastric distention during cardiopulmonary resuscitation is emphasized as a method of preventing gastroesophageal lacerations during external cardiac massage.
A Study of the Results of Treatment in 1,103 Cases of Lobar Pneumonia
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Human CD4+ CD25hi Foxp3+ regulatory T cells are derived by rapid turnover of memory populations in vivo
Authors: M. Vukmanovic-Stejic, Y. Zhang, J. E. Cook, J. M. Fletcher, A. McQuaid, J. E. Masters, M. H.A. Rustin, L. S. Taams, P. C.L. Beverley, D. C. Macallan, A. N. Akbar
Journal: Journal of Clinical Investigation (2006)
RED BLOOD CELL DIAMETER
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Treatment of Chronic Deafness by the Electrophonoide Method of Zünd-Burguet.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Upregulation of CCNB1, CDC20 and CENPF genes is associated with poor prognosis in hepatocellular carcinoma (HCC)
Authors: Tengfei Si, Yuanhang Jiang, Abigail Walker Jacobs, Shaqira Gill, Robert Hegarty, Mohammad Hamza, Shirin Elizabeth Khorsandi, Wayel Jassem, Nigel Heaton, Yun Ma
Journal: Journal of Hepatology (2020)
Motor Inhibition and Cognitive Flexibility in Obsessive-Compulsive Disorder and Trichotillomania
Authors: Samuel R. Chamberlain, Naomi A. Fineberg, Andrew D. Blackwell, Trevor W. Robbins, Barbara J. Sahakian
Journal: American Journal of Psychiatry (2006)

Problems with inhibiting certain pathological behaviors are integral to obsessive-compulsive disorder (OCD), trichotillomania, and other putative obsessive-compulsive spectrum disorders. The authors assessed and compared motor inhibition and cognitive flexibility in OCD and trichotillomania for the first time, to their knowledge.The Stop-Signal Task and the Intradimensiona/Extradimensional Shift Task were administered to 20 patients with OCD, 17 patients with trichotillomania, and 20 healthy comparison subjects.Both OCD and trichotillomania showed impaired inhibition of motor responses. For trichotillomania, the deficit was worse than for OCD, and the degree of the deficit correlated significantly with symptom severity. Only patients with OCD showed deficits in cognitive flexibility.Impaired inhibition of motor responses (impulsivity) was found in OCD and trichotillomania, whereas cognitive inflexibility (thought to contribute to compulsivity) was limited to OCD. This assessment will advance the characterization and classification of obsessive-compulsive spectrum disorders and aid the development of novel treatments.
Science
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Agglutinating-Sickling Arterial Thrombosis
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Book of Delight.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal