tbuckley/cabot-search huggingface dataset:
MEXICO
Journal: JAMA (1953)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Biosurfactant-Facilitated Remediation of Metal-Contaminated Soils
Authors: Raina M. Miller
Journal: Environmental Health Perspectives (1995)

Bioremediation of metal-contaminated wastestreams has been successfully demonstrated.Normally, whole cells or microbial exopolymers are used to concentrate and/or precipitate metals in the wastestream to aid in metal removal.Analogous remediation of metal-contaminated soils is more complex because microbial cells or large exopolymers do not move freely through the soil.The use of microbially produced surfactants (biosurfac- tants) is an alternative with potential for remediation of metal-contaminated soils.The distinct advantage of biosurfactants over whole cells or exopolymers is their small size, generally biosurfactant molecular weights are less than 1500.A second advantage is that biosurfactants have a wide variety of chemical structures that may show different metal selectivities and thus, metal removal efficiencies.A review of the literature shows that complexation capacities of several bacterial exopolymers was similar to the complexation capacity of a rhamnolipid biosurfactant produced by Pseudomonas aeruginosa ATCC 9027.
COLONIC ANESTHESIA
Authors: HERBERT WILLY MEYER
Journal: JAMA (1924)

As long as seventy-seven years ago, the idea of rectal anesthesia originated, and its gradual development has been most fascinating and successful. Roux<sup>1</sup>first suggested colonic ether anesthesia in 1847. Pirogoff<sup>2</sup>of St. Petersburg reported the same year on the use of ether mixed with water by rectum. Magendie soon called attention to its dangers and substituted ether vapor for the solution with markedly better results. However, no following was obtained for this method, although several reports appeared in the literature around that time. The next reference appeared thirty-seven years later, when in 1884 Yocum of Copenhagen and Molière<sup>3</sup>of Lyons reported on the use of hand bellows in forcing ether vapor into the rectum, and later on the use of an India rubber tube connected with an ether container immersed in water at 122 F. In the same year, Weir<sup>4</sup>and Bull<sup>5</sup>reported the
Incorrect Wording in: Will the History and Physical Examination Help Establish That Irritable Bowel Syndrome Is Causing This Patient's Lower Gastrointestinal Tract Symptoms
Authors: Gordon Doig, Fiona Simpson, Naomi Jones, Daren Heyland
Journal: JAMA (2009)

In Reply: The recent update of the Critical Care Nutrition Canadian Clinical Practice Guidelines aggregated the results of 14 randomized clinical trials of early enteral nutrition vs delayed nutrient intake.It observed that early enteral nutrition was associated with a statistically significant reduction in infectious complications (relative risk, 0.76; 95% confidence interval, 0.59-0.98;P = .04)and a statistically nonsignificant reduction in mortality (relative risk, 0.68; 95% confidence interval, 0.46-1.01;P = .06). 1 We therefore agree with Dr Finucane that existing evidence supporting a survival advantage associated with the delivery of early, aggressive artificial nutrition in critically ill patients is weak, but we would disagree that this is because an association does not exist.The results of 11 of these 14 RCTs favored early enteral nutrition, but it is likely that statistical significance was not reached due to small sample sizes.In addition, all 14 of these RCTs had inherent design flaws (unconcealed randomization, unblinded outcome assessment, or no intention-to-treat analysis) that tend to bias the results and may hamper the ability to detect statistically significant associations.We believe that the body of evidence generated by the 205 RCTs conducted on nutrition therapy in 21 228 critically ill patients has unequivocally answered the question that artificial nutrition is effective in this setting, and therefore it would be unethical to conduct RCTs comparing artificial nutrition to no artificial nutrition.The controversy, and therefore the clinical equipoise to conduct further studies, exists over the optimal dose of energy and protein to provide in the early phase of critical illness and which subgroups might benefit the most from this intervention.
Council on Mental Health
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Circulating tumorf necrosis factor-? and interleukin-6 concentrations and hyperdynamic circulation in cirrhosis Div. of Gastroenterology, Dept. of Medicine, Veterans General Hospital-Taipei and National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
Journal: Hepatology (1995)

To systematically evaluate the accuracy of free hepatic vein pressure (FHVP), the internal reference for hepatic venous pressure gradient (HVPG).Diameter and pressure measurements were obtained in multiple locations within the hepatic vein, inferior vena cava (IVC), and right atrium on 30 hepatic venograms in 29 consecutive candidates for transjugular intrahepatic portosystemic shunt creation.On angiography, 15 patients (52%) had hepatic veins showing a normal and conical appearance, whereas the other 14 had irregular or narrow (maximal diameter ≤ 6 mm) veins. Diameters of hepatic veins increased from 4.4 mm ± 0.9 (range, 3.3–7 mm) at a peripheral position to 8.7 mm ± 3.0 (range, 5.0–15.5 mm; P < .001) at a central position, and respective pressures decreased from 10.9 mm Hg ± 3.7 (range, 3–17 mm Hg) to 7.4 mm Hg ± 3.7 (range, 0–14 mm Hg; P < .001). Gradients between wedged hepatic vein pressure and central free hepatic vein, IVC, and right atrium pressures were 17.2 mm Hg ± 5.4 (range, 4–33 mm Hg), 18.0 mm Hg ± 5.8 (range, 4–33 mm Hg), and 20.0 mm Hg ± 5.9 (range, 4–33 mm Hg), respectively. Pearson correlation coefficients were 0.679 between the HVPG and hepatic atrial pressure gradient (HAPG) and 0.889 between the wedged hepatic vein/IVC pressure gradient (HCPG) and HAPG.FHVP measurement depends on catheter tip position and vein morphology. Its use to calculate HVPG is not recommended. The high agreement between the HCPG and the HAPG suggests that both gradients may be used if one considers a systemic difference of 2 mm Hg.
Abstract 19385: Postprandial Hypotension, is it Real? The Preliminary Results of a Pilot Study
Authors: Ju-Hee Lee, Dae-Hwan Bae, Sang-Min Kim, Sang-Yeub Lee, Jang-Whan Bae, Kyung-Kuk Hwang, Dong-Woon Kim, Myeong-Chan Cho
Journal: Circulation (2015)

Introduction: Postprandial hypotension is an important hemodynamic abnormality but it is very under-recognized. We performed this pilot study to evaluate the prevalence of postprandial hypotension and the possible associations between postprandial blood pressure (BP) decline and other forms of BP variability in type 2 diabetes. Methods: We enrolled 21 patients with type 2 diabetes. All patients were examined with ambulatory BP monitoring and we recorded every meal time. Postprandial hypotension was defined as a systolic BP fall of at least 20 mmHg compared with baseline BP level. Results: Mean age was 64.4±11.8 years and 11 patients were female (52.4%). Overall systolic BP and diastolic BP are 127.4±13.2 mmHg and 73.4±9.8 mmHg. Overall systolic BP variability was 13.7±5.5. Average postprandial BP fall was 13.9±10.7 mmHg and the BP fall was most conspicuous after breakfast. Fourteen patients (67%) were experienced postprandial hypotension by definition. Among them, 6 patients (43%) were non-dipper, 5 patients (36%) were reverse dipper and a patient was extreme dipper. Average systolic BP variability was significantly higher in the patients with postprandial hypotension (15.1±6.2 vs. 10.9±1.9, P=0.02). Conclusions: Postprandial hypotension is common in type 2 diabetes and there is possible relationship between postprandial hypotension and other abnormal BP patterns. To clarify the clinical significance of postprandial hypotension, large sized long term prospective study is needed.
Diagnostic dilemmas in foot and ankle injuries
Authors: J. S. Keene
Journal: JAMA (1986)

Differential diagnosis of foot and ankle injuries should include (1) stress fractures of the great toe sesamoids, the shaft of the fifth metatarsal, and the tarsal navicular bone; (2) transchondral talar-dome fractures; (3) fractures of the os trigonum; and (4) dislocating peroneal tendons. Diagnosis of these injuries is challenging because the initial roentgenograms often are normal, and special clinical tests and ancillary studies are required. (<i>JAMA</i>1986;256:247-251)
Neutrophils Help Circulating Tumor Cells Metastasize
Journal: Cancer Discovery (2019)

Abstract Researchers have found that neutrophils can travel with circulating tumor cells (CTC) and promote metastasis. In patients with breast cancer and in mouse models, the presence of CTC–neutrophil clusters correlates with shorter progression-free survival, the study revealed. Neutrophils may promote metastasis by releasing cytokines that promote cell-cycle progression, thus spurring the tumor cells to divide.
Author First and Last Names Inverted in Byline
Authors: John Barbieri, Jeremy Etzkorn, David Margolis
Journal: JAMA Dermatology (2019)

Brandon Worley, MD, MSc; Joshua L. Owen, MD, PhD; Christopher A. Barker, MD; Ramona Behshad, MD; Christopher K. Bichakjian, MD; Diana Bolotin, MD, PhD; Jeremy S. Bordeaux, MD, MPH; Scott Bradshaw, FRCP; Todd V. Cartee, MD; Sunandana Chandra, MD, MS; Nancy Cho, MD; Jennifer Choi, MD; M. Laurin Council, MD; Daniel B. Eisen, MD; Nicholas Golda, MD; Conway C. Huang, MD; Sherrif F. Ibrahim, MD, PhD; S. I. Brian Jiang, MD; John Kim, MD; Mario Lacutoure, MD; Naomi Lawrence, MD; Erica H. Lee, MD; Justin J. Leitenberger, MD; Ian A. Maher, MD; Margaret Mann, MD; Kira Minkis, MD, PhD; Bharat Mittal, MD; Kishwer S. Nehal, MD; Isaac Neuhaus, MD; David M. Ozog, MD; Brian Petersen, MD; Faramarz Samie, MD, PhD; Thuzar M. Shin, MD, PhD; Joseph F. Sobanko, MD; Ally-Khan Somani, MD, PhD; William G. Stebbins, MD; J. Regan Thomas, MD; Valencia Thomas, MD; David Tse, MD; Abigail Waldman, MD; Y. Gloria Xu, MD, PhD; Siegrid S. Yu, MD; Nathalie C. Zeitouni, MDCM, FRCPC; Tim Ramsay, PhD; Emily Poon, PhD; Murad Alam, MD, MSCI, MBA
Activity of cabozantinib (XL184) in hepatocellular carcinoma patients (pts): Results from a phase II randomized discontinuation trial (RDT).
Authors: Allen Lee Cohn, Robin Katie Kelley, Tsai-Shen Yang, Wu-Chou Su, Chris Verslype, David A. Ramies, Yihua Lee, Xiaodong Shen, Eric Van Cutsem
Journal: Journal of Clinical Oncology (2012)

261 Background: Cabozantinib is an oral, potent inhibitor of MET and VEGFR2. MET over-expression has been observed in advanced hepatocellular carcinoma (HCC). Anti-VEGF pathway agents have shown clinical benefit in pts w/ HCC. Simultaneous targeting of the MET and VEGF signaling pathways with cabozantinib may therefore be a promising treatment strategy. Methods: HCC pts with progressive measurable disease, per mRECIST received cabozantinib at 100 mg qd PO over a 12 week Lead-in period. Up to one prior regimen was allowed and only pts with Child-Pugh score of A were eligible. Tumor response was assessed every 6 weeks. Treatment beyond Week 12 was based on response: pts with PR continued open-label cabozantinib, those with SD were randomized to cabozantinib vs. placebo, and those with PD discontinued study drug. The primary endpoint was overall response rate (RR) per mRECIST in the Lead-in period, and progression free survival for pts who entered the randomized period. Results: Enrollment has been completed with 41 pts. Results are available for 34 pts. Median age: 61 years (33 to 83). Males: 24/34 (71%). Asian: 13/34 (38%). HCC etiology: Hepatitis B or C 12/34 (35%); alcohol abuse 5/34 (15%); other 17/34 (50%). Extrahepatic spread was observed in 21/34 (62%). The median number of prior systemic treatments was 1; prior sorafenib: 16/34 (47%). Most common related AEs ≥Grade 3 were hand-foot syndrome (15%), diarrhea (9%) and thrombocytopenia (9%). 3/33 pts evaluable for tumor assessment at 12 weeks achieved PR by original RECIST (RR 9%). One additional pt randomized at Week 12 achieved PR at 18 weeks and treatment remains blinded on study for &gt;1 year. 24/30 pts (80%) with ≥1 post-baseline scan had tumor regression (with no apparent relationship to prior sorafenib therapy). The overall disease control rate (DCR = PR+SD) at Week 12: 71% (Asian subgroup: 77%). Median time on study: 6 mos (1 to 15+ mos). AFP responses (defined as reduction from baseline of &gt;50%) in 21 pts with ≥1 post-baseline result: 9/21 (43%). Conclusions: Cabozantinib exhibits clinical activity in HCC pts with advanced disease, regardless of prior sorafenib treatment as reflected by tumor reduction, high DCR and time on study.
WHY ABSTRACTS?
Authors: J. R. E.
Journal: Annals of Internal Medicine (1961)

Editorials1 May 1961WHY ABSTRACTS?J. R. E.J. R. E.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-54-5-1030 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn this issue the Editors are initiating a policy of publishing in the ANNALS abstracts of papers presented at the current Annual Session of The American College of Physicians. Our reasons for doing so are two. First, such publication extends to all readers of the ANNALS who were not in attendance a bird's-eye view of the scientific papers presented at the Annual Session. Second, the abstracts are placed on record in the permanent medical literature.The first of these reasons needs no further justification, the second should be an added inducement to the investigators to submit for the program their... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1961Volume 54, Issue 5Page: 1030-1031 ePublished: 1 December 2008 Issue Published: 1 May 1961 PDF downloadLoading ...
Ushering in a New Generation of Diagnostics
Journal: JAMA (1986)

CURRENTLY, IT TAKES three to six weeks to confirm a clinical diagnosis of tuberculosis. Investigators are working on two different approaches to reduce diagnostic time: serodiagnosis using an enzyme-linked immunosorbent assay (ELISA) and DNA probes. Patrick J. Brennan, PhD, professor of microbiology at Colorado State University, Ft Collins, and coworkers have developed a serological test that looks for antibodies to a<i>Mycobacterium tuberculosis</i>-specific glycolipid (<i>J Bacteriol</i>1986;168:917-922). They have tested its specificity in animals hyperimmunized against an array of atypical mycobacteria, and have not detected any cross-reactivity, says Brennan. The next steps will be conducting extensive serological testing in the serum of patients with mycobacterial infections, and determining if the test also can detect the glycolipid in sputum. Thomas M. Daniel, MD, chair of the Department of Medicine at Case Western Reserve University, Cleveland, has been working on identifying, purifying, and characterizing an antigen specific to<i>M tuberculosis</i>. His
Methylsulfonyl Metabolites of PCBs and DDE in Human Tissues
Authors: Cecilia Weistrand, Koidu Noren
Journal: Environmental Health Perspectives (1997)

Methylsulfonyl metabolites of chlorinated biphenyls (MeSO2-CBs) and p,p'-DDE (MeSO2-DDEs) were determined in human adipose and liver tissues obtained at autopsy of seven Swedish individuals 47-80 years of age. Twenty MeSO2-CBs and two MeSO2-DDEs were found in the analyzed samples. In adipose tissue, most of the 4-MeSO2-CBs were found at higher concentrations than the corresponding 3-MeSO2-CBs and, in all samples of adipose tissue, 4-MeSO2-2,2',3',4',5-pentaCB (4-87) and 4-MeSO2-2,2',3,4',5',6-hexaCB (4-149) occurred at higher concentrations than other MeSO2-CBs. In the liver, 3-MeSO2-2,2',3',4',5,6-hexaCB (3-132) was by far the most abundant MeSO2-CB, contributing to 61-82% of the sum of MeSO2-CBs. In this tissue, most of the other 3-MeSO2-CBs were also found at higher concentrations than the corresponding 4-MeSO2-CBs. The ratios of the sum of MeSO2-CBs to the sum of determined chlorinated biphenyls (CBs) were 1/250 and 1/28 in adipose tissue and the liver, respectively, calculated from the median values. The concentration of 2-MeSO2-DDE was lower than that of 3-MeSO2-DDE in both adipose tissue and liver, except in the liver from one of the individuals. The concentration ratios of 2-MeSO2-DDE to 3-MeSO2-DDE were about 10 times higher in liver than in adipose tissue. The ratios of the sum of MeSO2-DDEs to p,p'-DDE were 1/455 and 1/61 in adipose tissue and liver, respectively, calculated from the median values. MeSO2-CBs and MeSO2-DDEs were also determined in lung tissue from one of the individuals. In this sample, the profiles of MeSO2-CBs and MeSO2-DDEs were similar to the profiles of these compounds in adipose tissue.
Tarrasch, of Breslau
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Operatively Treated Patients With Herniated Lumbar Disk, but Without Objective Radicular Findings
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Amateur Boxing
Authors: J. L. Blonstein, E. Clarke
Journal: BMJ (1955)

IMaillard reaction, then small amounts of lysine, histidine, and arginine must be very effective in producing the brown colour, inasmuch as only 2% of the total protein amino-acids would take part in the reaction during five years' storage."In relation to curd and nitrogen storage, the investigation conducted at the Pennsylvania State College School of Agriculture by Professor Dizikes and F. J. Doan' shows that raw and pasteurized milk have unsatisfactory curd charac- teristics, since after three hours of digestion more than 50% of the nitrogen was found in curds failing to pass a 4-mesh screen.At this same stage-that is, three hours and 4-mesh --breast milk gave 0.0%, unsweetened evaporated milk 0.26%, and boiled milk 10.60%.We trust this information will show our anxiety not to rest content with our product, and that we take into account as many factors as are currently known in relation to the use of a substitute food for infants when breast feeding is not possible.-Iam, etc.,