tbuckley/cabot-search huggingface dataset:
Beyond tricyclics: outlook on antidepressive treatments
Authors: E. R. Gonzalez
Journal: JAMA (1980)

Tricyclic antidepressants are not for everyone. Because some depressed persons do not respond to these drugs at all or have severe adverse reactions, certain discarded treatments for depression are again finding favor, while new ones proliferate. "Monoamine oxidase inhibitors [MAOIs] have been looked at askance, for example, but they will probably be coming back more and more," says Jan Fawcett, MD, chief of psychiatry at Rush-Presbyterian-St Luke's Medical Center in Chicago. "They didn't seem efficacious in early studies—the dosages in those studies were too low—but in higher dosages they appear to be very effective for many patients who do not respond to tricyclics." Newer pharmacotherapies include a spate of chemicals tested widely in Europe and elsewhere but minimally in the United States, such as the tetracyclics which are popular in England. For the most part, these drugs have proved no more efficacious than tricyclics and are equally toxic
Artificial insemination by donor: survey reveals surprising facts
Journal: JAMA (1979)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Highlights
Journal: JAMA (2016)

Ganz and colleagues found that a 9-protein risk score-derived from the results of largescale analysis of 1130 circulating proteins in a cohort of 938 patients with stable coronary artery disease and validated in an independent cohort of 971 patients-performed better than the Framingham secondary event risk score in predicting incident cardiovascular events.In an Editorial, Sabatine discusses the aptamer-based technology used in the study and relevance of the fi ndings for patient care.
Role of drugs in fractures of the femoral neck
Authors: R. Logan, S Rashiq
Journal: BMJ (1986)

To investigate the role of drugs in the rising incidence of fractures of the femoral neck in the elderly a case-control study inquiring about the use of prescribed drugs was carried out.The drug histories of 102 patients with femoral neck fractures were obtained from general practice records and compared with those of204 controls matched for age and sex from the same practices.At the time offracture 41 patients-with fractures and 126 controls were receiving at least one prescription (relative risk of fracture of the femoral neck in patients taling drugs=0*42, p=00006).For all types' of prescribed drugs except antibiotics the risk of fracture ofthe femoral neck was less in patients taking drugs than in those not doing so, and this was true at all times in the year before fracture.Six patients with fractures were receiving
INFANTILE PARALYSIS
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
New Appliance
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Trip Postponed.
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Polyneuropathy after mechanical ventilation
Authors: J. W. Teener
Journal: JAMA (1996)

<h3>In Reply.</h3> —Dr Ogden exaggerates the impact of nicotine reemission. The concentration of nicotine in unoccupied settings is negligible, and neglecting it introduces only a minor error, whereas including the entire sampling time would grossly underestimate the true exposure of workers. Although the details of nicotine adsorption and reemission are not known, the rapid decay of nicotine has been widely reported.<sup>1,2</sup>The average concentration measured over the full week may be expressed by the following formula: where h indicates hours; C<sub>week</sub>, average nicotine concentration over a full week; C<sub>work</sub>, average nicotine concentration during work; C<sub>decay</sub>, average nicotine concentration during the first hour after work; C<sub>night</sub>, average nicotine concentration overnight; and C<sub>weekend</sub>, average nicotine concentration over the weekend. Data collected in a realistic setting, the inside of a furnished trailer,<sup>2</sup>indicate that nicotine decays rapidly, to 10% of the initial level within 30 minutes
Polyarteritis Nodosa: A Syndrome
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Miscellany
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ankylosing Spondylitis
Authors: K. Sicher
Journal: BMJ (1949)

<h3>Abstract</h3> Ticks are second only to mosquitoes as vectors of disease to humans and animals. Commercial insect repellents reduce or prevent potentially infectious tick bites by disrupting tick host-seeking behavior. Tick host-seeking is mainly ascribed to the Haller’s organ, a complex sensory structure on the tick foreleg that detects odors, carbon dioxide and heat <sup>4–7</sup>, but these host-seeking mechanisms and the mechanism of their disruption by repellents are not well understood<sup>1,2</sup>. There is anecdotal evidence that ticks and other ectoparasites are attracted to heat, but it has never been demonstrated that they use radiant heat to detect hosts at a distance. In fact, previous attempts to do this have concluded that radiant heat is not used by ticks. Here we show that <i>Amblyomma americanum</i> and <i>Dermacentor variabilis</i> ticks can sense and home in on a human from several meters away, guided by radiant heat sensed by the Haller’s organ, and specifically the capsule, a covered spherical pit organ. An aperture in the capsule cover confers directionality and highly reflective interior surfaces of the capsule provide high sensitivity. Low concentrations of the insect repellents DEET, picaridin, 2-undecanone, citronellal and nootkatone eliminate thermotaxis without affecting olfactory-stimulated host-seeking behavior. Our results demonstrate that the tick Haller’s organ capsule is a radiant heat sensor used in host-finding and that repellents disrupt this sense at concentrations that do not disrupt olfaction. We anticipate this discovery to significantly aid insect repellent research and development of innovative strategies for protection against ectoparasites and vector-borne disease.
Abstract 2524: Hallmarks of kinase fusions in Chinese tumors
Authors: Lin Shi, Limuge Ce, Yanyan Wang, Zisong Zhou, Jing Ma, Hua Dong, Yizhou Ye, Shuyang Sun
Journal: Cancer Research (2019)

Abstract Kinase fusions are essential drivers to tumor genesis and generally response well to kinase inhibitors. Kinase fusion protein often represent ideal targets and many fusion genes have been well established as therapeutic targets as well as biomarkers, such as BCR-ABL fusion in CML and ALK fusion in lung cancer. In a CAP certified lab 3DMed we describe here a pan-cancer analysis of 8599 patient samples from assayed with comprehensive genomic profiling. Tissue samples were sequencing with a lab validated Masterview gene panel with intronic baiting for 30 fusion genes. Plasma samples were sequencing with a lab validated CGP150 gene panel with intronic baiting for 16 fusion genes. The kinase fusions genes we analyzed are included in both gene panels. Fusions were detected by a sensitive, breakpoint based method and the results were confirmed by manual inspection of the soft-clipped reads. Tumor mutational burden (TMB) was determined by coding region SNV and indel variant counts per Mb for tumor tissue sample only. We collect evidence for all possible gene fusion alterations in all the qualified samples and then focused on the analysis of kinase fusions in lung tissue samples. We surveyed gene fusions across 20 solid tumor types. 196/8599 (2.3%) samples harbored kinase fusion. 31.7% samples are from lung cancer patients and 74% of the 196 kinase fusions are found in lung cancer samples. The average of TMB score in kinase fusion positive samples was 5.17 vs. 11.35 (Wilcox test, P &amp;lt; 0.001) for lung cancer cases. 13% of the kinase fusions positive lung cancer samples co-occur with a known driver mutation such as EGFR or ALK mutation. TMB score in subgroup with kinase fusion (with or without another oncogene driver mutation) is significantly lower than that of subgroup without fusion (Wilcox test, P &amp;lt; 0.01). TMB scores in the kinase fusion positive patients is significantly lower than the fusion negative patients, which suggests that the kinase fusion positive subgroup may not response well to the immune checkpoint inhibitor. There are unmet clinical needs for more fusion kinase inhibitors with the increasing detection sensitivity for kinase fusions by NGS. Our finding have immediate clinical implications for cancer diagnosis and expand the therapeutic options for cancer patients’ care, as approved or exploratory drugs exist for many of these kinases. Citation Format: Lin Shi, Limuge Ce, Yanyan Wang, Zisong Zhou, Jing Ma, Hua Dong, Yizhou Ye, Shuyang Sun. Hallmarks of kinase fusions in Chinese tumors [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2524.
POSTPARTUM HEMORRHAGE
Authors: Louis H. Douglass
Journal: JAMA (1952)

<h3>To the Editor:—</h3> InThe Journalof June 21, 1952, there is an article by Dr. Ernest Myller titled "Control of Postpartum Hemorrhage" (page 757). In this article I am quoted as saying it is my "belief... that when the first uterine packing is not successful, the uterus is probably ruptured. If such is the case, a second packing is definitely contraindicated." This is not only a complete misquote, it is also contrary to my teaching of a number of years. The correct quotation from the source used by Dr. Myller is "... severe postpartum hemorrhage which does not respond to massage and the rather efficient oxytocic agents, when given intravenously, particularly when it occurs in the multigravida, is quite likely to be due to a partial or a complete rupture of the uterus. If this be present, packing will not only do no good, but will actually be harmful, in
Potential Molecular Mechanisms of Oxidant-Induced Carcinogenesis
Authors: Janis H. Jackson
Journal: Environmental Health Perspectives (1994)

Chronic exposure to oxidants is associated with an increased incidence of malignancy; however, the mechanism(s) by which oxidants contribute to carcinogenesis is unknown.Since oncogene activation plays an important role in carcinogenesis, we hypothesized that hydroxyl radical-induced DNA damage might contribute to carcinogenesis by causing oncogene activation.The studies reported herein demonstrate that hydroxyl radical- induced DNA damage can activate the K-ras 4B and C-Raf-I oncogenes by causing point mutations and deletions, respectively.In addition, our results indicate that a) hydroxyl radical-induced DNA damage causes selective base substitutions; b) the four DNA bases have different susceptibilities to hydroxyl radical-induced mutations; and c) hydroxyl radical-induced mutations are not randomly distributed among oncogene codons.Our studies suggest that oncogene activation could be one potential mechanism by which oxidants contribute to carcinogenesis.-
Spring Downsizing
Authors: Ronald Pies
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
High-dose and low-dose systemic corticosteroids are equally efficient in acute severe asthma
Authors: CH Marquette, B Stach, E Cardot, JF Bervar, F Saulnier, JJ Lafitte, P Goldstein, B Wallaert, AB Tonnel
Journal: European Respiratory Journal (1995)

The optimal amount of systemic corticosteroids to be used in acute severe asthma remains an unresolved issue. In this double-blind, randomized study we compared two doses of methylprednisolone (1 vs 6 mg.kg-1 q.d.) in asthmatics presenting with an acute severe asthma attack, unresponsive to an intensive beta 2-agonist regimen administered during a run-in period. Concurrent therapy, including oxygen, inhaled and intravenous salbutamol, and aminophylline was strictly standardized. The response was assessed by serial bedside spirometry. The primary outcome measurement was forced expiratory volume in one second (FEV1) (expressed as percentage of predicted values) at 24 and 44 h. The trial was designed in order to achieve a statistical power of 90%. Twenty three patients were included in the low-dose group and 24 in the high-dose group. Both groups were comparable in terms of demographic profiles, history of asthma, and severity of the current attack. Improvement in pulmonary function was similar in both groups. At 44 h, the mean (+/- SD) FEV1 values were 53 +/- 22 and 45 +/- 14% in the low and in the high-dose group respectively (NS). We conclude that high dose systemic corticosteroids offer no further benefit over low-doses in the treatment of severe acute asthma.
Papers on Psycho-Analysis.
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
This Week in &lt;EMPH&gt;JAMA&lt;/EMPH&gt;
Journal: JAMA (2004)

Jacobijn Gussekloo, MD, PhD; Eric van Exel, MD, PhD; Anton J. M. de Craen, PhD; Arend E. Meinders, MD, PhD; Marijke Frölich, PhD; Rudi G. J. Westendorp, MD, PhD
BMA asks juniors to contact MPs on long hours
Journal: BMJ (1987)

According to the chairman, the technical sub- committee had discussed about two thirds of the package and he hoped to present a written report to the next meeting ofthe JCC inJuly.He emphasised that the whole package would have to be agreed before any more of it could be implemented.Reporting on the discussions on retirement, Dr Brian Lewis said that there would be little on offer for consultants before the age of 60.The prospects after 60
The Scientific Program
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal