tbuckley/cabot-search huggingface dataset:
Abstract 3361: Phosphoglucose isomerase/autocrine motility factor mediates epithelial-mesenchymal transition regulated by miR-200 in breast cancer cells
Authors: Aamir Ahmad, Amro Aboukameel, Dejuan Kong, Zhiwei Wang, Avraham Raz, Fazlul H. Sarkar
Journal: Cancer Research (2011)

Abstract Phosphoglucose isomerase/autocrine motility factor (PGI/AMF), a housekeeping gene product that plays a key role in both glycolysis and gluconeogenesis pathways, is associated with invasion and metastasis of cancer cells. PGI/AMF is involved in the induction of Epithelial-to-Mesenchymal transition (EMT) phenotype in breast cancer cells, which leads to increased aggressiveness; however, the molecular mechanism by which PGI/AMF regulates EMT is not known. Here, we show, for the first time, that the over-expression of PGI/AMF leads to an increase in the DNA-binding activity of NF-κB, which in turn causes increased expression of ZEB1/ZEB2. Since microRNA-200s (miR-200s; miR-200a, miR-200b and miR-200c) are known to negatively regulate the expression of ZEB1/ZEB2, we assessed their expression and found that the expression of miR-200s was lost in PGI/AMF over-expressing MCF-10A cells as well as in highly invasive MDA-MB-231 cells, which was consistent with increased expression of ZEB1/ZEB2. Moreover, silencing of PGI/AMF expression in MDA-MB-231 cells led to re-expression of miR-200s, which was associated with the reversal of EMT phenotype i.e. Mesenchymal-to-Epithelial Transition (MET), and these findings were consistent with alterations in the relative expression of epithelial (E-cadherin) and mesenchymal (vimentin, ZEB1, ZEB2) markers, and decreased aggressiveness, as judged by clonogenic, motility and invasion assays. Silencing of PGI/AMF was also found to result in significantly reduced pulmonary metastases in vivo. Collectively, these results suggest, for the first time, the role of miR-200s in PGI/AMF induced EMT-MET, and thus clinical approaches for up-regulation of miR-200s could become a novel therapeutic strategy for the treatment of highly invasive breast cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3361. doi:10.1158/1538-7445.AM2011-3361
VERMIFORM APPENDIX, WITH SUPPURATION, IN FEMORAL HERNIA
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Recognition of growth hormone secretory disorders
Authors: W. H. Daughaday
Journal: JAMA (1984)

The demonstration by Raben<sup>1</sup>that only growth hormone (GH) extracted from human or primate pituitaries could stimulate growth in pituitary dwarfs was a milestone in clinical endocrinology. Because the supply of GH from human pituitaries was limited, endocrinologists concentrated on determining who was "truly" GH deficient by measuring serum GH levels after the induction of hypoglycemia or the administration of arginine, levodopa, clonidine, and other potent GH secretogogues. Rises in serum GH levels to more than 7 to 10 ng/mL were considered "normal." Because a minority of apparently normal children might fail to respond to any one stimuli, the National Pituitary Program required failure to respond to two appropriate stimuli to qualify for GH treatment. The prospect of the more general availability of bacterially synthesized methionyl GH has led to a reexamination of GH secretion in short children. There is legitimate concern that GH response to potent pharmacologic stimuli
SOCETY PROCEEDINGS.
Journal: JAMA (1888)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Collective Investigation of Disease.
Journal: JAMA (1883)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Binding and Distribution Studies in the SENCAR Mouse of Compounds Demonstrating a Route-Dependent Tumorigenic Effect
Authors: Gary P. Carlson, Anthony A. Fossa, Mark A. Morse, Patrice M. Weaver
Journal: Environmental Health Perspectives (1986)

Previous investigators have determined that benzo(a)pyrene [B(a)P] was much more effective in causing skin papillomas if applied topically than when administered orally in the initiation-promotion assay in SENCAR mouse. Conversely, urethane and acrylamide caused a higher percentage of mice to develop papillomas and induced more tumors per mouse when given orally. In an attempt to understand the reason for this discrepancy in route dependency, 3H-benzo(a)pyrene, 14C-urethane and 14C-acrylamide were administered as single doses orally or topically to male SENCAR mice. Distribution in skin, stomach, liver, and lung was determined for time periods up to 48 hr. The binding of these compounds to DNA, RNA, and protein in these tissues was determined 6 and 48 hr after administration. For all three compounds, high concentrations were found in the skin following topical application, but very little material reached this target organ following oral administration. In contrast, the internal organs generally contained more material after oral administration. The binding of label compounds to DNA, RNA, and protein generally reflected the distribution data, thus more compound was bound in the stomach, liver, and lung after oral administration compared to topical application, whereas the opposite was true for the skin. This finding was particularly evident for B(a)P. The results suggest that differences in distribution to the skin and binding to macromolecules following oral or topical administration cannot explain the greater tumorigenicity of urethane and acrylamide after oral administration in the SENCAR mouse.
Medical care of the US Olympic Team
Authors: D. F. Hanley
Journal: JAMA (1976)

EACH quadrennium, the officers and Board of Directors of the United States Olympic Committee appoint a Games Preparation Committee, Concerned with organizing the total team effort for the Olympic Games. This Committee is the supervisory group for all US Olympic Committee activities at the Games and is made up of chairmen of the following sub-committees: Team Services, Apparel, Supplies and Equipment, Food and Housing, Medical Advisory, Ticket Services, and Transportation. The Medical Advisory Committee selects the medical personnel who will travel with and provide medical care for the athletes and officials of the US Olympic team at the Games. This Medical Advisory Committee also surveys the medical environment at the site of the Games, arranges for the medical supplies and equipment, and has supervisory function at the Games. Selections for the Medical and Training Services unit are made from a pool of applicants, some of whom, because of their knowledge
Highlights
Journal: JAMA (2016)

Liraglutide in Advanced Heart Failure 500 Preclinical models and early clinical studies suggest glucagon-like peptide-1 (GLP-1) agonists have cardioprotective eff ects in heart failure.Margulies and colleagues assessed whether treatment with the GLP-1 agonist liraglutide-initiated within 2 weeks of hospitalization for acute heart failure and continued for 180 days-would improve clinical stability in a randomized study involving 300 patients with established heart failure and reduced left ventricular ejection fraction.The authors report that, compared with placebo, use of liraglutide did not lead to greater clinical stability after hospitalization for heart failure.CME jamanetworkcme.com
Commentaire de travail de A. Glitsch et al., pp. 192
Journal: Endoscopy (2008)

See also: Endoscopic transanal vacuum-assisted rectal drainage (ETVARD): an optimized therapy for major leaks from extraperitoneal rectal anastomosesEndoscopy 2008; 40(03): 192-199DOI: 10.1055/s-2007-995384
Withdrawal of Thalidomide ("Distaval")
Authors: D. J. Hayman
Journal: BMJ (1961)

<i>Aspergillus fumigatus</i>, a common mold, rarely infects humans, except during prolonged neutropenia or in cases of chronic granulomatous disease (CGD), a primary immunodeficiency caused by mutations in the NADPH oxidase that normally produces fungicidal reactive oxygen species. Filamentous hyphae of <i>Aspergillus</i> are killed by normal, but not CGD polymorphonuclear leukocytes (PMN); however, the few studies on PMN-mediated host defenses against infectious conidia (spores) of this organism have yielded conflicting results, some showing that PMN do not inhibit conidial growth, with others showing that they do, most likely using reactive oxygen species. Given that CGD patients are exposed daily to hundreds of viable <i>A. fumigatus</i> conidia, yet considerable numbers of them survive years without infection, we reasoned that PMN use ROS-independent mechanisms to combat <i>Aspergillus</i>. We show that human PMN from both normal controls and CGD patients are equipotent at arresting the growth of <i>Aspergillus</i> conidia in vitro, indicating the presence of a reactive oxygen species-independent factor(s). Cell-free supernatants of degranulated normal and CGD neutrophils both suppressed fungal growth and were found to be rich in lactoferrin, an abundant PMN secondary granule protein. Purified iron-poor lactoferrin at concentrations occurring in PMN supernatants (and reported in human mucosal secretions in vivo) decreased fungal growth, whereas saturation of lactoferrin or PMN supernatants with iron, or testing in the presence of excess iron in the form of ferritin, completely abolished activity against conidia. These results demonstrate that PMN lactoferrin sequestration of iron is important for host defense against <i>Aspergillus</i>.
Editorial
Authors: P Bulois
Journal: Endoscopy (2017)

Ce numéro d'endoscopy contient une sélection des résumés des travaux relatifs à l'endoscopie retenus pour présentation aux Journées Francophones d'Hépato-gastro-entérologie et d'Oncologie Digestive (JFHOD) 2017. Cette sélection témoigne une nouvelle fois du dynamisme de la recherche francophone en endoscopie digestive.
ADDICTION TO GLUTETHIMIDE (DORIDEN)
Authors: ARNOLD SADWIN, ROBERT S. GLEN
Journal: American Journal of Psychiatry (1958)

1. Glutethimide may become an addicting drug when used by patients with a history of addiction. 2. Signs and symptoms of an acute organic brain syndrome may be produced in a patient intoxicated by glutethimide. 3. Such symptoms are reversible. 4. In order to control withdrawal symptoms, suggested that the drug be reduced gradually.
Home birth
Authors: N. P Springer, C. Van Weel
Journal: BMJ (1996)

Table-Odds ratio for various sampling devices for detecting mild dyskaryosis or worse relative to extended tip spatula alone.Odds ratios have been calculated by pooling all studies and adjusting for underlying rate in each study.All studies Screening only Referral only Odds ratio (95% No of smears confidence No of smears Odds ratio (95% No of smears Odds ratio (95% taken Interval) taken confidence) taken confidence)Extended tip 27 939 1.00 11 302 1.00 905 1.00 Ayre 14 329 0.87 (0.79 to 0.96) 1232 0.49 (0.24 to 1.01) 1039 0.92 (0.69 to 1.23) Ayre plus* 11 459 1.09 (0.97 to 1.23) 7373 0.57 (0.26 to 1.29) 911 1.63 (1.24 to 2.15) Extended tip plus* 12 023 1.08 (0.95 to 1.22) 7342 1.14 (0.77 to 1.69) 954 1.77 (1.27 to 2.46) Brush or swab 2302 0.75 (0.62 to 0.90) 1050 0.32 (0.15 to 0.70) 1252 1.04 (0.79 to 1.36) Cervex 10 054 1.05 (0.96 to 1.16) 3381 1.00 (0.62 to 1.61) 280 1.37 (0.87 to 2.14) Cytopick 3406 1.08 (0.68 to 1.73) 34061.10 (0.66 to 1.82) 0 -Bayne 4320 1.12 (0.80 to 1.57) 4320 0.59 (0.25 to 1.40) 0 *Cytobrush or cotton swab.Note that some studies had a mixture of screening referral smears or were conducted in gynaecology clinics and have only been included as "all studies."
Insect Vectors of Disease
Authors: Vlado A. Getting
Journal: New England Journal of Medicine (1945)

Control of Insect-Borne DiseasesSpace does not permit complete discussion of the control of various types of insect-borne diseases. There are, however, certain factors that apply to most of these diseases.In the normal course of an epidemiologic investigation, collections are made of the insects suspected of transmitting the disease in question. The best method for collecting insects is to take advantage of their feeding habits. Adult mosquitoes may be collected either while biting man or while resting on walls and ceilings.51 A large glass test tube, containing rubber bands saturated with carbon tetrachloride or chloroform at the bottom is . . .
Editorial: Brain abscess.
Journal: BMJ (1975)

Unexplained Prolonged Fever in ChildrenPaediatricians and family doctors from time to time face one ofthe most challenging clinical problems-pyrexia ofunknown origin, or P.U.O.Most such fevers are short-lasting and are probably due to viral infections; but when the fever persists diagnosis is more difficult and more important.Fourteen years ago Petersdorf and Beeson' suggested that P.U.O.should be defined as fever of at least three weeks, exceeding 38 3°C on several occasions, and defying diagnosis after a week of intensive hospital investigation.They claimed that most cases proved to be atypical manifestations of common diseases rather than exotic conditions.In their study of 100 cases in Boston 36% were due to infections, 19°/o were neoplasms, and 20% were collagen-vascular diseases.The figures in another
In Reply:
Authors: Olivier Glehen, François Noël Gilly
Journal: Journal of Clinical Oncology (2003)

IN REPLY:We appreciated the comments from Shen and Loggie, emphasizing the necessity of strict selection of patients with peritoneal carcinomatosis who are candidates for aggressive cytoreductive surgery and intraperitoneal chemohyperthermia (IPCH).As we reported in our article [1], we selected our 56 patients from 240 who were referred to us for a potential therapeutic approach combining cytoreductive surgery and IPCH.Strict selection of patients is, for us, an essential key for acceptable morbidity and mortality rates.Patients older than 65 years; with poor performance status, severe renal or cardiovascular disease, extraperitoneal disease; or with evidence of unresectable disease on clinical or radiological examination were not included in our protocol.The completeness of cytoreduction is probably the major prognostic indicator for most of the patients with peritoneal carcinomatosis, whatever the primary tumor is, and the chance to achieve a complete cytoreduction is higher in patients with low-volume disease.However, the crucial need of complete cytoreduction depends on primary tumor location as well as pathologic type of tumor.Its influence on survival is probably different in patients with carcinomatosis from colorectal malignancy compared with ovarian tumors or pseudomyxoma peritonei.For each pathologic type of carcinomatosis we have to define more clearly the role of cytoreductive surgery, IPCH, and other prognostic indicators.Our experience, as well as that reported by Sugarbaker [2], Zoetmulder [3], and Shen and Levine [4], demonstrates that the therapeutic approach combining cytoreductive surgery and IPCH may be the most promising new treatment for peritoneal carcinomatosis for the next decade.It offers hope for cure to patients who had in the past no escape from terminal illness.Many questions still need to be answered, and phase III studies are needed to improve the selection criteria for patients who may benefit from this comprehensive management.However, phase III studies are not the only way to demonstrate the efficiency of this therapeutic approach.We recently initiated an international registry including more than 500 patients with colorectal carcinomatosis from more than 30 institutions, treated by the combined therapeutic approach of cytoreductive surgery with a curative intent and perioperative intraperitoneal chemotherapy with or without hyperthermia.A similar registry approach was used to evaluate surgery for the treatment of liver metastasis from colorectal origin [5], and may be appropriate in the setting of peritoneal carcinomatosis.
The herbal medicine Inchin-ko-to inhibits liver cell apoptosis induced by transforming growth factor beta 1
Authors: M YAMAMOTO
Journal: Hepatology (1996)

Transforming growth factor beta 1 (TGF-beta 1) is reported to play an important role in the induction of liver cell apoptosis. In this report, we demonstrate that TGF-beta 1 induces apoptosis in a rat Morris hepatoma McA-RH8994 cell line and rat primary cultured hepatocytes at similar doses and in a similar manner. Using McA-RH8994 cells, we screened a number of chemical reagents, aqueous extracts of crude drugs, and herbal medicines for their inhibitory activities on TGF-beta 1-induced apoptosis. The results indicate that Artemisiae capillaris spica (ACS) and the ACS-containing herbal medicine Inchin-ko-to, which are used for treatment of various liver disorders, exhibited the most potent anti-apoptotic activity. Various chemicals that were reported as inhibitors of apoptosis in other experimental systems showed no evident activity. By contrast, two of nine ACS ingredients we tested, capillin and capillene, showed activity at concentrations of submicrogram per milliliter. The inhibitory effects of Inchin-ko-to, capillin and capillene were also confirmed on TGF-beta 1-induced apoptosis of rat primary cultured hepatocytes. Inhibition of undesired apoptosis induced by TGF-beta 1 is expected to be beneficial for the treatment of various inflammatory liver diseases. Our findings therefore suggest the possibility that therapeutic effects of Inchin-ko-to on liver diseases might be associated with its inhibitory activity on TGF-beta 1-induced liver cell apoptosis. (Hepatology 1996 Mar;23(3):552-9)
Seminar on Animal Models and Human Dermatopharmacology
Journal: JNCI Journal of the National Cancer Institute (1974)

Journal Article Seminar on Animal Models and Human Dermatopharmacology Get access JNCI: Journal of the National Cancer Institute, Volume 52, Issue 6, June 1974, Page 1941, https://doi.org/10.1093/jnci/52.6.1941 Published: 01 June 1974
Correction to: The first-in-class alkylating deacetylase inhibitor molecule tinostamustine shows antitumor effects and is synergistic with radiotherapy in preclinical models of glioblastoma
Authors: C. Festuccia, A. Mancini, A. Colapietro, G. L. Gravina, F. Vitale, F. Marampon, S. Delle Monache, S. Pompili, L. Cristiano, A. Vetuschi, V. Tombolini, Y. Chen, T. Mehrling
Journal: Journal of Hematology & Oncology (2018)

The original article [1] contained an error whereby Fig. 4 displayed incorrect magnification scales.
Worried to Death?
Authors: Lana L. Watkins, James A. Blumenthal
Journal: Circulation (1999)

Hogue et al 1 concluded: "In the hour before AF [atrial fibrillation] after CABG surgery, higher heart rate and lower heart rate complexity compared with values in control patients were independent predictors of AF." Their careful study and stochastic analyses showed that this was statistically significant, but their observations were not clinically significant for the following reasons.After CABG operations, many patients have AF for a few minutes or hours without a fast ventricular rate or emboli.Even new AF that lasts for a day or more usually disappears spontaneously without bad results.In a series of 100 consecutive patients who had cardiac operations, all patients who entered the hospital in regular sinus rhythm left the hospital in regular sinus rhythm in spite of intervening AF. 2 Predicting harmless as well as harmful AF as a single set does not influence treatment or help the patients in other ways.Concerning patients who acquire AF after acute myocardial infarction (MI), the American College of Cardiology/American Heart Association stated, "Although AF after acute MI is usually transient, heparin therapy should be given to patients not already receiving it." 3Hogue et al 1 reported 1 patient who had AF and then appeared to have a fatal cerebral embolism on postoperative day 2.There was time to give this patient heparin, and the patient probably received it.Predicting that the patient would have AF would not have helped.Predicting which patients will have persistent hazardous AF is a different matter.Such a prediction would justify vigorous treatments in these few patients to prevent AF.Such treatment would not be reasonable for all patients at risk for this arrhythmia after CABG operations.
Coronary artery disease in combat casualties in Vietnam
Authors: J. J. McNamara
Journal: JAMA (1971)

Postmortem coronary angiography and dissection of hearts from 105 United States soldiers killed in Vietnam demonstrate that (1) 45% have some evidence of atherosclerosis; (2) 5% have gross evidence of severe coronary atherosclerosis; and (3) no patient had angiographic evidence of severe coronary narrowing, and in only one patient was any degree of stenosis observed.