tbuckley/cabot-search huggingface dataset:
Angiographic Study of Cerebral Circulation Time During Hypothermia
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Penicillin Allergy
Authors: John W. Irwin, Mary J. Graham, Bernard M. Jacobson, Walter S. Burrage
Journal: New England Journal of Medicine (1951)

PENICILLIN has had wide use since its introduction into clinical medicine, yet severe reactions to this drug have been few although many cases and various types of allergic reactions have been reported. The most common manifestations of sensitivity have been urticaria and angioedema.1 2 3 Contact dermatitis among persons handling the drug has also been described,4 5 6 7 and vesicular dermatitis is not rare.8 , 9 Reactions similar to the Arthus phenomenon have come to the attention of two investigators.10 , 11 One group12 wrote of a tuberculin type of sensitivity, and McClosky and Smith13 produced anaphylaxis in guinea pigs sensitized to penicillin. Several authors14 15 16 17 have reported anaphylactic . . .
Condoms and the Vatican
Authors: None The Lancet
Journal: The Lancet (2006)

Ethical issues are rarely black and white. Grey is often the colour of compassion. But for the Catholic Church the use of condoms to protect against acquiring HIV, even within a marriage where one person is HIV positive, is considered a sin. Contraception is wrong, the Catholic Church says, whatever the circumstances—even when condoms are not used to prevent pregnancies, but to prevent a fatal infection. However, Cardinal Javier Lozano Barragán, the head of the Pontifical Council for Health Pastoral Care, suggested that this stance might soon change as Pope Benedict XVI has commissioned "a very profound scientific, technical, and moral study" on this issue.
American Journal of Psychiatry, Hanover, NH
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Authors' Reply
Authors: Tor B Stuge, Peter P Lee
Journal: PLoS Medicine (2005)

Gatz's statement, "At least half of the explanation for individual differences in susceptibility to Alzheimer disease is genetic" [1], is, in my opinion, incorrect.As the one who led the team debating Ashford and Mortimer, whose 2002 article [2] supports this statement, at the 2001 conference on Alzheimer disease (AD) in Cincinnati ("Challenging Views of Alzheimer's Disease") [3], I think that the evidence that dietary and lifestyle factors explain the majority of the individual risk for AD in the US is very strong.My original paper in 1997 [4] found that total dietary fat and energy intake were the most important dietary risk factors, while fi sh and cereal intake were the most important risk reduction factors.These fi ndings have been generally confi rmed by Drs.Luchsinger and Morris and others.The reason I did my study was that the Honolulu Heart Study reported that Japanese American men in Hawaii had 2.5 times the risk of AD of native Japanese.African-Americans have about four times the risk of AD of native Nigerians.If genetics were the primary risk factor, those living in the US would have a risk of developing AD very similar to that of individuals living in their ancestral home.The reason this is not the case is that the American diet provides too much food, which is a particular problem for those genetically predisposed to AD.
PROSTATECTOMY.REPORT OF 51 CASES OPERATED ON FROM MAY 6, 1901, TO FEBRUARY 26, 1904.
Authors: JOHN B. MURPHY
Journal: JAMA (1904)

<h3>Case 25.</h3> —Mr. S. C., aged 57 years. Occupation, weigher. Admitted to Mercy Hospital Jan. 11, 1903. <h3>Present Illness.</h3> —Began five years ago with increased frequency of urination. For a few years he was troubled only during the winter months. Since one month ago symptoms have been very much aggravated. During the last week severe pain and straining have given but litltle rest. He urinates every twenty to twenty-five minutes. <h3>Examination of Patient.</h3> —Prostate very much enlarged. Urinalysis: acid, 1013, clear, albumin present, few blood cells and many pus cells in the centrifuged specimen. <h3>Operation.</h3> —Jan 12, 1903: Regular technic. Patient discharged from hospital Feb. 16, 1903. Report March 29, 1904: Wound has remained permanently healed. No pain at any time. Holds urine during day from two to three hours and at night for four or five hours. Has perfect control of
Dracunculiasis
Authors: A. L. Ribeiro
Journal: BMJ (1954)

IFN-γ–inducible protein 16 (IFI16) recognizes viral DNAs from both nucleus-replicating viruses and cytoplasm-replicating viruses. Isoform 2 of IFI16 (IFI16-iso2) with nuclear localization sequence (NLS) has been studied extensively as a well-known DNA sensor. However, the characteristics and functions of other IFI16 isoforms are almost unknown. Here, we find that IFI16-iso1, with exactly the same length as IFI16-iso2, lacks the NLS and locates in the cytoplasm. To distinguish the functions of IFI16-iso1 and IFI16-iso2, we have developed novel nuclear viral DNA mimics that can be recognized by the nuclear DNA sensors, including IFI16-iso2 and hnRNPA2B1. The hexanucleotide motif 5′-AGTGTT-3′ DNA form of the nuclear localization sequence (DNLS) effectively drives cytoplasmic viral DNA nuclear translocation. These nuclear viral DNA mimics potently induce IFN-β and antiviral IFN-stimulated genes in human A549 cells, HEK293T cells, and mouse macrophages. The subcellular location difference of IFI16 isoforms determines their differential functions in recognizing viral DNA and activating type I IFN–dependent antiviral immunity. IFI16-iso1 preferentially colocalizes with cytoplasmic HSV60mer and cytoplasm-replicating vaccinia virus (VACV), whereas IFI16-iso2 mainly colocalizes with nuclear HSV60-DNLS and nucleus-replicating HSV-1. Compared with IFI16-iso2, IFI16-iso1 induces more transcription of IFN-β and IFN-stimulated genes, as well as stronger antiviral immunity upon HSV60mer transfection or VACV infection. IFI16-iso2, with the ability of nuclear-cytoplasmic shuttling, clears both invaded HSV type 1 and VACV significantly. However, IFI16-iso2 induces more type I IFN–dependent antiviral immunity than IFI16-iso1 upon HSV60-DNLS transfection or HSV type 1 infection. Our study has developed potent agonists for nuclear DNA sensors and also has demonstrated that IFI16 isoforms with cytoplasmic and nuclear locations play differential roles in innate immunity against DNA viruses.
Futility and the ethics of resuscitation
Authors: T. Tomlinson
Journal: JAMA (1990)

Recent recommendations that physicians be allowed to withhold cardiopulmonary resuscitation, without patient consent, from patients for whom it would be futile have drawn objections that such unilateral judgments would undermine respect for patient autonomy. These objections assume that since futility determinations involve value judgments, patient input is always required. However, certain sorts of value judgments must be made unilaterally by physicians as part of reasonable medical practice. Moreover, the mixed messages inherent in requesting patient consent to withhold futile therapy serve to undermine rather than to enhance autonomous choice. Real patient interests can better be served by a broad public dialogue around judgments of medical reasonableness and medical futility, rather than concern for the form but not the substance of patient autonomy. (<i>JAMA</i>. 1990;264:1276-1280)
Observations on 125 Cases of Viper Bite
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dermatology
Authors: John H. Epstein
Journal: JAMA (1978)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A physician retraining program. Assessment update
Authors: A. C. Raub
Journal: JAMA (1982)

The Medical College of Pennsylvania, Philadelphia, has sponsored a retraining program for clinically inactive physicians since 1968. A previous study examined return to clinical medicine of retrainees from 1968 to 1975. The present study tracked changes in physician characteristics from 1976 to 1981 and compared return to clinical medicine of retrainees in the two time periods. Although important shifts in gender, nature of inactivity, status of licensure, and geographic distribution occurred during the past five years, the number of retrainees returning to clinical activity after the program was comparable for the two time periods (85% and 83%). Women inactive because of family responsibilities and non-clinically active physicians made more career changes than non-primary care clinical specialists. This study demonstrated that a retraining program is an effective method of reintroducing inactive physicians to clinical medicine. (<i>JAMA</i>1982;248:2994-2998)
Invasive
Journal: JAMA (2004)

guidance document to help public health and health-care officials detect the reappearance of SARS-CoV in the United States quickly and implement a decisive and effective public health response.The document, "Public Health Guidance for Community-Level Preparedness and Response to Severe Acute Respiratory Syndrome (SARS)," is available at http://www.cdc.gov/ncidod/sars/sarsprepplan.htm.
Precision Medicine
Authors: Veneta Masson
Journal: Annals of Internal Medicine (2016)

Ad Libitum3 May 2016Precision MedicineVeneta Masson, RN, MAVeneta Masson, RN, MAFrom Washington, DC.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M16-0222 Audio Reading - “Precision Medicine” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Precision Medicine," by V. Masson. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The latest way to make the luckiest humans in history anxious during their short stay on Earth.—Richard Lehman, BMJOh yes, I say,this is what I want,precision medicine.Let the data flow.Mine my genomefor glitches and clues.Retrofit what you can andwhat you can't, wellat least I'll knowthe condition I fearcan't be fixedprecisely.My anxiety's highbut knowledge is prizedand much has been gainedwith my help.I might do fine.Not all genes expressand mistakes can be madein labs and trialsand the non-coding genomeis massive, complexand, for all I know, the placewhere luck is transcribed. Author, Article, and Disclosure InformationAffiliations: From Washington, DC.Current Author Address: Vaneta Massonm RN, MA; e-mail, veneta.[email protected]com. PreviousarticleNextarticle Advertisement Audio Reading - “Precision Medicine” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Precision Medicine," by V. Masson. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 3 May 2016Volume 164, Issue 9Page: 610KeywordsAnxietyFearPrecision medicine ePublished: 3 May 2016 Issue Published: 3 May 2016 Copyright & PermissionsCopyright © 2016 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
IBD/pathophysiology
Authors: R Salupere, V Salupere, P Aitola, J Mattila, M Halonen, C Muhoz, R G6mez, M Alcantara, J Martinez, T Artaza, V Flores, F Tordera
Journal: Gut (1994)

3rd UEGWOslo 1994 apy had been stopped.All symptoms and laboratory findings improved and patients gained physical activity.A few patients suffered from short-period attacks of bloody diarrhea after therapy had been ended.Complaints dis- appeared in nearly 10 days under a dose scheme of 3 x 3. 106 lU/week.Besides well-known side-effects, large ulcered and gross bleeding external hemorrhoids were observed in 4 patients.Conclusions: The results of the study suggest that Interferon alfa-2a may be benefit to colon mucosa in patient with Ulcerative Colitis and therapeutical effect of drug results probably from its immunomodulatory and/or antiviral properties.
Oncogenic Osteomalacia
Authors: DANIEL WEISS
Journal: Annals of Internal Medicine (1985)

Letters and Corrections1 April 1985Oncogenic OsteomalaciaDANIEL WEISS, M.D., ROBERT S. BAR, M.D., NOEL WEIDNER, M.D.DANIEL WEISS, M.D.Search for more papers by this author, ROBERT S. BAR, M.D.Search for more papers by this author, NOEL WEIDNER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-102-4-557_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Taylor and associates (1) report the case of a patient they claim had oncogenic osteomalacia and inappropriate antidiuretic hormone secretion due to oat-cell carcinoma. Several points may lead one to question this claim.First, with regard to the appearance and location of the tumors causing oncogenic osteomalacia, we have reported the cases of three patients with hypophosphatemic osteomalacia caused in each case by small asymptomatic tumors (2, 3). A maxillary sinus tumor that caused the syndrome in one patient had the roentgenographic appearance of a mucous retention cyst. This tumor was found only in the course of...References1. TAYLOR H, FALLON M, and VELASCO M. Oncogenic osteomalacia and inappropriate antidiuretic hormone secretion due to oat-cell carcinoma. Ann Intern Med. 1984;101:786-8. LinkGoogle Scholar2. WEISS D, BAR R, WEIDNER N, WENER M, and LEE F. Oncogenic osteomalacia: strange tumors in strange places. Postgrad Med J. 1985. (In press). CrossrefMedlineGoogle Scholar3. WEIDNER N, BAR R, WEISS D, and STROTTMANN M. Neoplastic pathology of oncogenic osteomalacia/rickets. Cancer. 1985. (In press). CrossrefMedlineGoogle Scholar4. SWEET R, MALES J, HAMSTRA A, and DELUCA H. Vitamin D metabolite levels in oncogenic osteomalacia. Ann Intern Med. 1980;93:279-80. LinkGoogle Scholar5. RYAN E and REISS E. Oncogenous osteomalacia: review of the world literature of 42 cases and report of 2 new cases. Am J Med. 1984;77:501-12. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DANIEL WEISS, M.D.; ROBERT S. BAR, M.D.; NOEL WEIDNER, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byOsteomalacia inducida por tumorMost Osteomalacia-associated Mesenchymal Tumors Are a Single Histopathologic EntityReview and Update: Oncogenic Osteomalacia-RicketsMaladie de recklinghausen avec hypophosphorémie et ostéomalacie 1 April 1985Volume 102, Issue 4Page: 557-557KeywordsAntidiuretic hormone ePublished: 1 December 2008 Issue Published: 1 April 1985 PDF downloadLoading ...
Abstract 12120: Intracranial Pressure Increases Both During Mild Therapeutic Hypothermia and During Rewarming Period in Post Cardiac Arrest Patients
Authors: Hiromichi Naito, Eiji Isotani, Clifton W Callaway, Shingo Hagioka, Naoki Morimoto
Journal: Circulation (2015)

Introduction: Elevation of intracranial pressure (ICP) may induce secondary brain injury and worsen the neurological outcome. Some studies on traumatic brain injury show that rapid rewarming can result in poorer outcomes contributory due to elevation of ICP. However, little is known about ICP during therapeutic hypothermia (TH) and rewarming period in post cardiac arrest patients. Hypothesis: We tested if there is occurrence of increased ICP during mild TH and rewarming period and whether it is related to outcome in patients resuscitated after cardiac arrest. Methods: Comatose patients resuscitated from cardiac arrest, treated with TH and ICP monitored were enrolled in the study. Surface cooling device was used for TH. Patients were maintained in target core temperature of 34 °C for 24 hrs. Thereafter, the temperature was regulated to increase to normothermia (37.0 °C) at the rate of 0.25 °C/hr. ICP and cerebral perfusion pressure (CPP) were monitored during the period. Cerebral Performance Category (CPC) scale was obtained 28 days later. Results: Data of 9 patients were analyzed (8 [89 %] men, age: 62 ± 17 years, cardiac origin 3 [33 %]/non-cardiac origin: 6 [67 %], CPC 1: 2 patients; CPC 2: 1 patient; CPC 3: 1 patient; CPC 4: 2 patients; CPC 5: 3 patients). ICP was 7.7 ± 4.4 mmHg at the beginning of TH and significantly elevated to 17.4 ± 13.3 mmHg at the end of TH (p = 0.03). ICP was 23.6 ± 19.1 mmHg at the end of rewarming which was higher than the end of TH (p = 0.04). At the end of rewarming, ICP value ranged in variety from 10 mmHg (CPC 1) to 68 mmHg (CPC 5). CPP was 81.3 ± 15.6 mmHg at the beginning of TH and was 72.1 ± 22.7 mmHg (p = 0.22) at the end of rewarming. All the cases with CPP less than 40 mmHg within 48 hrs died. Conclusions: ICP is increasing both during TH of target temperature 34°C and during rewarming at speed of 0.25 °C/hr in patients after cardiac arrest. Increment of ICP seems to be greater in cases with poorer outcome. CPP decrease was not usually observed and was limited to fatal cases.
Essential Drugs
Authors: JOAN-RAMON LAPORTE
Journal: Annals of Internal Medicine (1981)

Letters and Corrections1 February 1981Essential DrugsJOAN-RAMON LAPORTE, M.D.JOAN-RAMON LAPORTE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-94-2-281_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I read with interest the editorial note "The World Health Organization List of 'Essential Drugs'"(1) in the August issue. As Lasagna points out, the list is proposed as a "model which can furnish a basis for countries to identify their own priorities and to make their own selection." This is why chlorpheniramine is listed as the sole antihistamine, meperidine (pethidine) and morphine as the only potent analgesics, and promethazine as the sole antiemetic. Lasagna does not indicate that these three drugs are listed with an explanatory note that indicates "listed as an example of this therapeutic category...References1. LASAGNA L. The World Health Organization list of "essential drugs." Ann Intern Med. 1980;93:368-9. Editorial note. LinkGoogle Scholar2. The Selection of Essential Drugs. Geneva: World Health Organization; 1979. (WHO Technical Report Series 641.) Google Scholar3. British National Formulary. London: British Medical Association and Pharmaceutical Society of Great Britain; 1976. Google Scholar4. Formulário Nacional de Medicamentos. Lisboa: Direcçao-Geral dos Hospitais; 1978. Google Scholar5. Prontuario 1978 per la pratica terapeutica extraospedaliera. Roma: Il Pensiero Scientifico, 1978. Google Scholar6. Index Farmacològic 1980. Barcelona: Acadèmia de Ciències Mèdiques de Catalunya i de Balears; 1980. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByDrugs in the Spanish Health System 1 February 1981Volume 94, Issue 2Page: 281-281KeywordsAnalgesicsAntihistaminesDrugsGlobal healthMorphine Issue Published: 1 February 1981 PDF DownloadLoading ...