tbuckley/cabot-search huggingface dataset:
SMILE A WHILE
Authors: None Percyevsky
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Penicillin
Authors: R. G. Petersdorf
Journal: JAMA (1969)

Except for the sulfonamides, penicillin is the oldest antibacterial agent available, has been in general clinical use for nearly a quarter of a century, and has been administered to several hundred million people. However, since its inception, many antimicrobial drugs with the same or similar antibacterial spectrum have been discovered, raising the question as to whether other drugs might be superior to penicillin. In the minds of some, this question has been reinforced by the recent decision of the NAS-NRC Drug Efficacy Review Panel that penicillin-sulfonamide and penicillin-streptomycin combinations are not efficacious.<sup>1</sup> Penicillin is uniformly bactericidal in low concentrations against group A streptococci, pneumococci, nonpenicillinase-producing staphylococci, meningococci, and, in somewhat higher concentrations, gonococci, and certain enteric bacteria. It is also a potent treponemocidal agent. Translated into the clinical setting, this means that penicillin is highly effective in most cases of exudative pharyngitis, otitis media, pneumonia, meningitis (except for infants
Tryptophan
Authors: Larry M. Leadbetter
Journal: JAMA (1990)

<h3>To the Editor.—</h3> Regarding the article<sup>1</sup>concerning the eosinophilia-myalgia syndrome as a new clinical entity, one also must consider the serotonin syndrome as first described by Insel et al,<sup>2</sup>who noted that increased serotonergic activity was associated with restlessness, unsteady gait, elevated temperature, hyperreflexia, myoclonic responses, and cardiac arrhythmias. This has been further observed by Kline et al<sup>3</sup>in individuals taking tryptophan and serotonin uptake inhibitors. It is possible that the syndromes are different presentations of a similar underlying defect or alteration of serotonin metabolism. The clinical features of the eosinophilia-myalgia syndrome are generally peripheral in nature regarding the activity of serotonin, while those in the serotonin syndrome are central in origin. The serotonin syndrome occurs acutely following administration of tryptophan, frequently within hours, and resolves within 24 hours. The eosinophilia-myalgia syndrome has a more insidious/chronic course of weeks to years, with resolution often not certain. Therefore,
Prospective Study of Wide Excision Alone for Ductal Carcinoma In Situ of the Breast
Authors: Michael D. Lagios, David L. Page, Melvin J. Silverstein
Journal: Journal of Clinical Oncology (2006)

In their review of Ki-67 and breast cancer, Urruticoechea, Smith, and Dowsett 1 are correct that in vivo labeling of S-phase breast cancer cells with bromodeoxyuridine (BrdU) is "laborious" and that proliferation rate measured with in vivo labeling of S-phase tumor cells with BrdU is a useful "gold standard."However, four of the five references they list report in vitro, not in vivo labeling with BrdU, 2-5 and the fifth reference does not include BrdU at all. 6 There has been one published comparison of in vivo BrdU and Ki-67 in breast cancer.This study found a high correlation between Ki-67 and in vivo labeling of S-phase cells with BrdU. 7 Both of these indices of proliferation indicated risk of recurrence in the first 5 years that was comparable to, and not statistically different from, prognostic information based on node status. 8 This study with in vivo BrdU is unlikely to be repeated because (1) in vivo BrdU cannot be recommended for widespread clinical use and (2) Ki-67 has emerged as a readily obtained marker of proliferation that correlates highly with both in vivo and in vitro labeling of S-phase tumor cells with BrdU.
Intensive glucose control did not prevent important complications in type 2 diabetes
Authors: Victor M. Montori
Journal: Annals of Internal Medicine (2008)

ACP Journal Club16 September 2008Intensive glucose control did not prevent important complications in type 2 diabetesVictor M. Montori, MD, MSc, German Malaga, MDVictor M. Montori, MD, MScMayo Clinic,, Rochester, Minnesota, USA (V.M.M.)Search for more papers by this author, German Malaga, MDUniversidad Peruana Cayetano Heredia, Lima, Peru (G.M.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-149-6-200809160-02006 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationThe ADVANCE Collaborative Group. Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med. 2008;358:2560-72. https://pubmed.ncbi.nlm.nih.gov/18539916Clinical Impact RatingsEndocrinology: Nephrology: References1 Stratton IM, Adler AI, Neil HA, et al. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. BMJ. 2000;321:405-12. [PMID: 10938048] Google Scholar2 Montori VM, Permanyer-Miralda G, Ferreira-González I, et al. Validity of composite end points in clinical trials. BMJ. 2005;330:594-6. [PMID: 15761002] Google Scholar3 Montori VM, Devereaux PJ, Adhikari NK, et al. Randomized trials stopped early for benefit: a systematic review. JAMA. 2005;294:2203-9. [PMID: 16264162] Google Scholar4 Singh S, Loke YK, Furberg CD. Long-term risk of cardiovascular events with rosiglitazone: a meta-analysis. JAMA. 2007;298:1189-95. [PMID: 17848653] Google Scholar5 Shichiri M, Kishikawa H, Ohkubo Y, Wake N. Long-term results of the Kumamoto Study on optimal diabetes control in type 2 diabetic patients. Diabetes Care. 2000;Supp 2:B21-9. [PMID: 10860187] Google Scholar6 Gaede P, Lund-Andersen H, Parving HH, Pedersen O. Effect of a multifactorial intervention on mortality in type 2 diabetes. N Engl J Med. 2008;358:580-91. [PMID: 18256393] Google Scholar Author, Article, and Disclosure InformationAffiliations: Mayo Clinic,, Rochester, Minnesota, USA (V.M.M.)Universidad Peruana Cayetano Heredia, Lima, Peru (G.M.)This article was published at Annals.org on 2 September 2008. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoIntensive glucose control increased mortality and did not prevent cardiovascular events in type 2 diabetes Victor M. Montori and German Malaga Metrics Cited byEffect of glycemic control on markers of subclinical atherosclerosis in patients with type 2 diabetes mellitus: A review 16 September 2008Volume 149, Issue 6Page: JC3-6KeywordsDrug regulationDrugsGlucoseHbA1cHypoglycemiaMortalityMyocardial infarctionRetinopathyType 2 diabetesVascular diseases ePublished: 16 September 2008 Issue Published: 16 September 2008 Copyright & PermissionsCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Gastroenterology and hepatology
Authors: R. S. Koff
Journal: JAMA (1995)

Colon cancer, the second leading cause of cancer deaths in the United States, is responsible for more than 57 000 deaths annually. More than 150 000 new cases are reported each year. While environmental risk factors remain under investigation as potential triggers of DNA injury that underlies carcinogenesis, the nature of the DNA lesions has been a focus of molecular medicine. The uncontrolled cell growth that leads to the development of colon cancer is now believed to result from a series of inherited or acquired mutations in DNA repair genes, oncogenes, and tumor suppressor genes. Hereditary nonpolyposis colon cancer, the most common form of inherited colon cancer, has been linked to a defective DNA repair gene that has been localized to the short arm of chromosome 2.<sup>1,2</sup>The defective gene appears to be carried by one in every 200 persons and may be responsible for as much as 15%
<i>Diseases of the Nervous System: A Text-Book of Neurology and psychiatry</i>. By Smith Ely Jelliffe, M. D., Ph. D., Adjunct Professor of Diseases of the Mind and Nervous System New York Post-Graduate Medical School and Hospital, and William A. White, M. D., Superintendent St. Elizabeth's Hospital, Washington, D. C., Professor of Nervous and Mental Diseases Georgetown University, etc. Second edition. Revised and enlarged. (<i>Philadelphia and New York: Lea and Febiger, 1917</i>.)
Journal: American Journal of Psychiatry (1918)
Plasma catecholamines in stress and exercise
Authors: J. E. Dimsdale
Journal: JAMA (1980)

A technique was devised to monitor plasma catecholamines in a minimally obtrusive fashion in subjects going about their working activities. There was a disparity between plasma norepinephrine and epinephrine levels in different situations. During public speaking, epinephrine levels increase twofold, whereas during physical exercise, norepinephrine levels increase threefold. It seemed that while exercise induces a response of the sympathetic nervous system, psychological stress induces primarily an adrenal response. (<i>JAMA</i>243:340-342, 1980)
Population-based analysis of a novel prognostic model for metastatic castration-resistant prostate cancer (mCRPC) patients (pts) treated with abiraterone acetate (AA).
Authors: Arun Azad, Renee Lester, Raya Leibowitz-Amit, Anthony Michael Joshua, Daniel Yick Chin Heng, Bernhard J. Eigl, Kim N. Chi
Journal: Journal of Clinical Oncology (2014)

29 Background: Using data from the COU-AA-301 trial, a novel prognostic model was recently developed for predicting overall survival (OS) in post-chemotherapy mCRPC pts treated with AA (J Clin Oncol 31, 2013 (suppl; abstr 5013)). The model is comprised of six pre-treatment risk-factors (RF) associated with poor outcome: ECOG performance status (PS) ≥ 2, presence of visceral metastases, time from start of LHRH agonists to start of AA ≤ 36 months, low albumin, high ALP and high LDH. The aim of this study was to evaluate this model in an unselected population-based cohort. Methods: Cancer registries at three Canadian centers were used to identify mCRPC pts treated with AA. OS was estimated using the Kaplan-Meier method. Multivariate Cox proportional hazard regression was used to determine independent prognostic factors for OS. Results: A total of 415 pts received AA – 286 were post-docetaxel and 129 were chemotherapy-naïve. In post-docetaxel pts, 21%, 50% and 28% were classified into good (0-1 RF), intermediate (2-3 RF) and poor (4-6 RF) prognosis (prog) groups respectively based on the COU-AA-301 model. Median OS in the post-docetaxel cohort was significantly longer for pts with good prog disease (23.9 months) compared to intermediate (17.6 months) and poor prog pts (8.4 months) (Table). ECOG PS (p&lt;0.001), LDH (p=0.025), albumin (p=0.007) and visceral metastases (p&lt;0.001) were confirmed as independent prognostic factors. Although the number of events in chemotherapy-naïve pts was low, median OS was significantly longer in good prog pts (not reached) compared to both intermediate (22.9 months; p=0.011, log-rank) and poor prog pts (10.3 months; p&lt;0.001, log-rank). Conclusions: In a population-based setting, our data validate the COU-AA-301 model as a tool for prognostic stratification of mCRPC pts treated with AA after docetaxel. Prospective evaluation of this prognostic model in post-docetaxel and docetaxel-naive pts commencing AA is warranted. [Table: see text]
THE DAILY PRESS AND THE "FUTILITIES OF CONTEMPORARY SCIENCE"
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Heberden Society: Clinical Meeting, May 1981
Authors: V Gibson, F Rodgers, H Court-Brown, M Mcguire, R Russell, G Murphy, J Reynolds, P Williams, J Gumpel
Journal: Annals of the Rheumatic Diseases (1981)

It has been suggested that the contribution of dietary purines to the development of hyperuricaemia has been underestimated.'The diets of gouty and non- gouty outpatients were compared.A 7-day, pro- spective dietary questionnaire was completed by 61 gout and 52 controls of similar age, sex, and social class.Results were detailed and verified by interview and average daily intakes of food constituents estimated.Gouty subjects consumed slightly less protein, carbohydrate and fats and marginally more calories.The mean ±SD purine intake of the gouty was 0-22±0t 1 g/day, a value which was identical to that of the controls.The average (±SD) alcohol intake of the gouty was 54 ±45 g/day and of controls 31 ±30 g/day (p<0 005).Twenty-five (41 %) of the gouty drank >60 g alcohol/day (>2 litres beer) and
Journals
Authors: Nicholas Comninellis
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ASSOCIATION OF MILITARY SURGEONS OF THE UNITED STATES
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Barriers to better care for people with AIDS in developing countries
Authors: Andrew S Furber, Ian J Hodgson, Alice Desclaux, David S Mukasa
Journal: BMJ (2005)

WHO9s 3 by 5 initiative to increase access to antiretroviral drugs to people with AIDS in developing countries is highly ambitious. Some of the biggest obstacles relate to delivering care. <b>Andrew S Furber</b> and colleagues explain
Paragliding injuries.
Authors: M Krüger-Franke, C H Siebert, W Pförringer
Journal: British Journal of Sports Medicine (1991)

Regulations controlling the sport of paragliding were issued in April 1987 by the German Department of Transportation. The growing popularity of this sport has led to a steady increase in the number of associated injuries. This study presents the incidence, localization and degree of injuries associated with paragliding documented in Germany, Austria and Switzerland. The 283 injuries suffered by 218 paragliders were documented in the period 1987-1989: 181 occurred during landing, 28 during starting procedures and nine during flight. The mean patient age was 29.6 years. There were 34.9% spinal injuries, 13.4% upper extremity injuries and 41.3% lower limb injuries. Over half of these injuries were treated surgically and in 54 instances permanent disability remained. In paragliding the lower extremities are at greatest risk of injury during landing. Proper equipment, especially sturdy footwear, exact training in landing techniques as well as improved instruction in procedures during aborted or crash landings is required to reduce the frequency of these injuries.
SOCIETY NEWS.
Authors: W. Scheppegrell
Journal: JAMA (1896)

<h3>The National Sanitary Association.</h3> —The second annual convention of this society was held in Brooklyn on October 14 and 15, Dr. Frederic Jewett, president. Important scientific business and the inspection of numerous public works important to sanitary officers in cities occupied the attention of the members to the full. At the closing session, officers for the ensuing year were chosen as follows: President, Dr. F. O. Young, Lexington, Ky.; vice-presidents, Drs. H. C. McLean, Brooklyn, N. Y., F. A. Wilson, Meriden, Conn., and C. S. Benedict, New York; secretary, T. E. Veal, Esq., Atlanta, Ga.; treasurer, J. Hoadley, Esq., New Haven, Conn.; executive committee, A. R. Moore, Esq., Brooklyn, N. Y., Drs. F. A. Jewett, Brooklyn, N. Y.; Wallace Sibley, Rochester, N. Y.; Archibald St. George, Fall River, Mass., and J. Hoadley, Esq. The third annual meeting was named for October, 1897, at Lexington, Ky. <h3>The Sixty-eighth Annual Congress of</h3>
Incorrect Confidence Intervals
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medical-Care Spending—United States
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Trauma and Disease
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal