tbuckley/cabot-search huggingface dataset:
On the Cause of Syncope and Sudden Death in Primary Pulmonary Hypertension.
Authors: T. N. James
Journal: Annals of Internal Medicine (1961)

s1 May 1961On the Cause of Syncope and Sudden Death in Primary Pulmonary Hypertension.T. N. James, M.D., (Assoc.)T. N. James, M.D., (Assoc.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-54-5-1034_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSyncope and sudden death are common clinical features of primary pulmonary hypertension. A number of hypotheses have been proposed to explain these phenomena but none has been fully satisfactory. One discrepancy has been the uncommon appearance of these features in secondary pulmonary hypertension.While studying the histopathology of the sinus node and its artery in a variety of diseases, a case of primary pulmonary hypertension was examined. The sinus node in this case was extensively infarcted. The sinus node artery was not only ruptured, but the media in all areas showed degeneration, both cystic and noncystic. More careful examination of... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1961Volume 54, Issue 5Page: 1034-1035KeywordsArteriesHistopathologyPulmonary arteriesPulmonary diseasesPulmonary hypertensionSyncope ePublished: 1 December 2008 Issue Published: 1 May 1961 PDF downloadLoading ...
Lumleian Lectures on Endocarditis
Authors: T. Horder
Journal: BMJ (1926)

OF ENDOCARDITIS.I PASS now to consider certain etiological factors in the production of endocarditis, both of the valve cusps and of the chambers of the heart' which, though the exclusion of a chronic infective element must only be presumed at any time with great caution, appear to be outside the sphere of microbic activity.Having spoken of the possibility of congenital defects in connexion with some cases of pure mitral steniosis I will take these first.It has been for a long time lheld that congenital defects in the heart are almost conifinied to tile right side of this organ.Such defects as are found in the left side, if we except those gross defects which lead to suchl massive disturbances of the circulation that there are early and lethal results, have been too lightly )assed over.There is good reason to believe that we lhave beeni too cavalier in our observations concerning t}e initimate anatomy of the heart valves, and of the aortic valve in particular, in relation to endocardial disease.Deviations from the normal in these delicate structures may well prove to be a determining factor in infection of a grade hitherto unsuspected.This possibility did niot escape the eyes of older observers.Thayer reminds us that tlhie recogniition of the fact that bicuspid aortic and pulmonary valves pre- dispose to disease is as old as Paget.Osler also pointed out the liability of these malformed segments to sclerotic endocarditis.Of seventeen cases examined by him all presented sclerotic changes, and the majority of them had, duiiing life, the clinical features of incompetence, Glynn) *rho gave the Lumleian Lectures upon.infective endocarditis in the year 1903, refers in detail to a specimen obtained from a nman aged 48 years, in which one of the two cusps was found to be torn and everted, and wrhose fatal illness started after a strain, durilng *hich it is piesumed that the diseased cusp was damaged.I pointed out in 1909 that congenital defects that weree compatible with good health and were outside the categoiy of those grosser lesions which were to be recognized durillglifoe might still be of great importance in inducing active eindocarditis.I cited cases of this as illustrated by defective inter- ventricular septum and patent ductus .arteriosus, in patients of 31 and 42 years of age -espectively.I drew special attention to the association of-bicuspid aortic valves with bacterial endocarditis in 1905 when publishing the first cases of endocarditis diue to Pfeiffer'-bacillus.In 1909 I dealt with this point more fully, having fouind bicuspid aortic valves in two other hearts in the= museum of St. Bartholomew's Hospital, each the site of bacterial endocarditis.I-stiil a-fourth specimen, from a case of
Palmar dermatoglyphics in heart disease. Differential studies in Japanese and American populations with congenital and acquired heart diseases
Authors: T. Takashina
Journal: JAMA (1966)

Palmar dermatoglyphic patterns on 44 patients with congenital heart disease were compared with patterns on 362 patients with acquired heart disease. Distal displacement (t" or multiple axial triradii) of the palmar axial triradii occurred with significantly greater frequency in the patients with congenital heart disease (64%), than in the patients with acquired heart disease (17%). Studies of the probability of the occurrence of these differences in palmar dermatoglyphics on a chance basis alone gave a value of less than 0.0000000001 for Japanese. This compares with a probability value of 0.0000634 for whites, and 0.0164 for Negroes. Dermatoglyphics is emerging as a clinical instrument and genetic tool of significance.
AMA To Offer Aid on Medicare Rules; Physicians' Ethical, Legal Role Defined
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SUPERFLUOUS SPECTACLES.
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Surgery of the Heart and Great Vessels
Authors: Dwight C. McGoon
Journal: New England Journal of Medicine (1968)

THIS report attempts to present a concise yet specific and impartial look at a broad area of cardiac surgery today. It cannot be thorough, nor can it be hoped that all authorities will agree with all its parts.The great pioneering surgeons who progressively developed successful procedures for the palliation and correction of so many cardiac diseases also originated or exploited many concomitant advances in technology, including the methods of extracorporeal circulation and the various types of intravascular prostheses. Clearly, any effort to append references or to give credit to the innumerable contributors to the progress of this great field . . .
The Role of Reactive Oxygen and Nitrogen Species in Airway Epithelial Gene Expression
Authors: Linda D. Martin, Thomas M. Krunkosky, Judith A. Voynow, Kenneth B. Adler
Journal: Environmental Health Perspectives (1998)

The body first encounters deleterious inhaled substances, such as allergens, industrial particles, pollutants, and infectious agents, at the airway epithelium.When this occurs, the epithelium and its resident inflammatory cells respond defensively by increasing production of cytokines, mucus, and reactive oxygen and nitrogen species (ROS/RNS).As inflammation in the airway increases, additional infiltrating cells increase the level of these products.Recent interest has focused on ROS/RNS as potential modulators of the expression of inflammation-associated genes important to the pathogenesis of various respiratory diseases.ROS/RNS appear to play a variety of roles that lead to changes in expression of genes such as interleukin-6 and intercellular adhesion molecule 1.By controlling this regulation, the reactive species can serve as exogenous stimuli, as intercellular signaling molecules, and as modulators of the redox state in epithelial cells.Unraveling the molecular mechanisms affected by ROS/RNS acting in these capacities should aid in the understanding of how stimulated defense mechanisms within the airway can lead to disease.
HYPNOTISM AND MEDICINE.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Genomics of Parallel Ecological Speciation in Lake Victoria Cichlids
Journal: Molecular Biology and Evolution (2018)

When we searched for genes overlapping with candidate regions of parallel selection on admixture-derived genetic variation, some genes in the NCBI gene list were not correctly read into R. Therefore, we unfortunately missed some genes in our paper.The full list of genes includes 202 genes overlapping with 35 of the 41 candidate regions of parallel selection.The paper, Supplementary table 3 and the visualization on Dryad: doi:10.5061/dryad.8p6m07g.2) have now been updated.Importantly, one of the previously missed genes is Kit ligand, a gene involved in pigmentation variation in sticklebacks and humans (Miller, et al. 2007).
FRI0136 Risk for Lung Cancer in RA and Different RA Phenotypes: Results from A Population-Based Case-Control Study
Authors: K. Chatzidionysiou, G. Reynisdottir, V. Joshua, T. Frisell, J. Askling, A. Catrina
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> It has been shown that patients with Rheumatoid Arthritis (RA) are at increased risk for certain malignancies, among them lung cancer. <h3>Objectives</h3> To investigate the association between lung cancer and different RA phenotypes based on rheumatoid factor (RF) and anti-citrullinated peptide antibody (ACPA) status. <h3>Methods</h3> We used the population-based case-control study EIRA (Epidemiological Investigation of Risk factors for Rheumatoid Arthritis). Patients with RA and controls (matched for age, sex, calendar period and area of residence) were included during 1996–2013. The data were linked to the Swedish nationwide cancer register. Cox regression was used to calculate RR. Due to the significant correlation between smoking and RA as well as presence of RF and ACPA, stratified analyses based on smoking status were performed, in order to account for effect modification. <h3>Results</h3> A total of 3547 RA patients and 5586 controls were included in the study. The mean age (SD) was 52 (13) years and the percentage of female was 72%. Significantly more RA patients than controls were diagnosed with lung cancer after RA diagnosis (58 vs. 26 per 100,000 patient-years, respectively, p=0.002). RA itself gave twice an increased risk for developing lung cancer when adjusted for age and sex (RR=1.9, 95% CI=1.2–3.2, p=0.01), but the statistical significance disappeared when smoking was included in the model. However, after stratification according to smoking status, RA was significantly associated to lung cancer development in never or ex-smokers (RR=2.4, 95% CI=1.0–6.2, p=0.05) but not in current smokers (RR=1.2, 95% CI=0.6–2.3, p=0.6). In RA patients, higher age, smoking, RF positivity, RF and/or ACPA positivity and double seropositivity were significant risk factors for lung cancer (table 1). In a stratified analysis RF positivity was significantly associated to lung cancer in non-smokers (table 2). <h3>Conclusions</h3> In this study RA, especially RF positive RA, was associated to the development of lung cancer in never or ex-smokers. Although not statistically significant, patients who developed lung cancer were more often positive for RF and/or ACPA irrespective of smoking status. <h3>Disclosure of Interest</h3> None declared
Lettsomian Lectures on the Influence of Climate in the Treatment of Pulmonary Consumption
Authors: C. T. Williams
Journal: BMJ (1876)

room when the dissection is made, as, though he decline to toucb, yet his person and clothes may become infected by the poison.There may possibly be a doubt whether one who dissects bodies altered by decomposition or antiseptic injections, as they are commonly found in the dissecting-room of medical schools, is so liable to contaminate a puerperal patient as he who makes an necropsy soon after death.Semmelweiss, however, believed that animal matter in a state of putrefaction would cause puerperal fever, and immediately lessened the mortality, during the fearful epidemic of puerperal fever which raged in the Vienna Hospital in I846 and 1847, by obliging all dissecting students to wash their hands in chlorine or chloride of lime before making vaginal examinations.Impressed by Semmelweiss's views and opinions, I endeavoured, during my occupancy of the Chair of Obstetric Medicine at King's College, to prevent studenits frequenting the dissecting- room and post mzortemt theatre from attending midwifery cases, and the result was a very small mortality in the outdoor materniity charity.This care about absolute cleanliness of the hands in attending labours should extend even to occasions wheni a medical man has had digitally to examine patients suffering from offensive discharges either proceed- ing from the surface or from the interior of the body.We have heard in this discussion that the clischarges from cancer may produce fever in a lying-in woman; and this is probably true of other putrescent dis- charges.I have had grave anxiety, extending over some weeks, about a patient after her delivery; because I had gone straight from an in- strumental case where labour had been so protracted that febrile symp- toms had set in, and the passages had become influenced, so as to pour out an irritating muco-purulent discharge.When a medical man has a bad case of puerperal fever in his own practice, or is required to see one in consultation, he should certainly not go direct to another midwifery patient without first changing his clothes, besides careful ablution of his hands; and he will be all the safer in his ministrations if he adopt some of those precautions men- tioned by Dr. Swayne and others, such as using a Turkish bath, or the more radical measures for disinfection recommended by Dr. Wynn Williams, and for the details of which I may refer to his speech.* Concluded from page 7 of last number.In the first part of this paper, at page 5, column i. line 5 from bottom, for " individual", read " tindivided"; anid in column 2a line 26 from bottom, for "meat, soup, and bread", read " meat-soup and bread".
384P BLU-945, a highly potent and selective 4th generation EGFR TKI for the treatment of EGFR T790M/C797S resistant NSCLC
Authors: S.S. Schalm, T. Dineen, S.M. Lim, C.W. Park, J. Hsieh, R. Woessner, Z. Zhang, K. Wilson, M. Eno, D. Wilson, B. Williams, J. Campbell, C. de Savi, F. Stevison, C. Utt, T. Guzi, M. Dorsch, K. Hoeflich, B.C. Cho
Journal: Annals of Oncology (2020)
Anatomy
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ABC of heart failure: Management: diuretics, ACE inhibitors, and nitrates
Authors: C R Gibbs, M K Davies, G Y H Lip
Journal: BMJ (2000)

M K Davies , C R Gibbs , G Y H Lip In the past 15 years several large scale, randomised controlled trials have revolutionised the management of patients with chronic heart failure. Although it is clear that some drugs improve symptoms, others offer both symptomatic and prognostic benefits, and the management of heart failure should be aimed at improving both quality of life and survival. Diuretics and angiotensin converting enzyme (ACE) inhibitors, when combined with non-pharmacological measures, remain the basis of treatment in patients with congestive heart failure. Digoxin has a possible role in some of these patients, however, and the potential benefits of β blockers and spironolactone (an aldosterone antagonist) in chronic heart failure are now increasingly recognised. ### Aims of heart failure management #### To achieve improvement in symptoms #### To achieve improvement in survival Diuretics are effective in providing symptomatic relief and remain the first line treatment, particularly in the presence of oedema. Nevertheless, there is no direct evidence that loop and thiazide diuretics confer prognostic benefit in patients with congestive heart failure. In general, diuretics should be introduced at a low dose and the dose increased according to the clinical response. There are dangers, however, in either undertreating or overtreating patients with diuretics, and regular review is necessary Loop diuretics - frusemide (furosemide) and bumetanide - have a powerful diuretic action, increasing the excretion of sodium and water via their action on the ascending limb of the loop of Henle. They have a rapid onset of action (intravenously 5 minutes, orally 1-2 hours; duration of action 4-6 hours). Oral absorption of frusemide may be reduced in congestive heart failure, although the pharmacokinetics of bumetanide may allow improved bioavailability. ### How to use diuretics in advanced heart failure
Skeletal Renewal and Metabolic Bone Disease
Authors: William H. Harris, Robert P. Heaney
Journal: New England Journal of Medicine (1969)

Adrenocortical SteroidsNowhere in the study of skeletal responses is the influence of species specificity more apparent than in the responses to perturbations in circulating levels of adrenocortical steroids. The rabbit becomes markedly osteopenic when given cortisone,89 but the intact dog does not, even if very high doses of steroids are used. Increased or decreased density of metaphyseal bone can be produced in rats given exogenous cortical steroids, depending on the calcium and phosphorus intake.90 The conclusion of Follis91 that the zone of increased density in the metaphyseal area of cortisone-treated rats as compared with pair-fed controls was due to . . .
Ultrasound plus mammography may detect more early cancers
Journal: BMJ (2002)

the views were based on real experiences of using report cards.These findings should not derail an initiative that has the potential to improve accountability and stimulate improvements in quality.However, the technical barriers, the antipathy of the general public, the impact on professional morale, and the opportunity costs of focusing on public reporting at the expense of other health service reforms, should not be discounted.Policy makers, managers, and health professionals should understand these barriers, recognise the limitations of directly transferring experience from the United States, and ensure that the implementation of public reporting in the United Kingdom is guided by relevant evidence.
Galvanic, Faradic and Sinusoidal Apparatus.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal