tbuckley/cabot-search huggingface dataset:
Comparison of cardiovascular risk between patients with type 2 diabetes and those who had had a myocardial infarction: cross sectional and cohort studies
Journal: BMJ (2002)

Main findingsSerious physical illness was independently associated with suicide.However, physical illness seemed to be a stronger predictor in men.We found no such association in women, possibly because of small numbers, though there may be a real sex difference.Impaired vision was a predictor of suicide in our study.While visual impairment has been shown to be associated with depression in later life, 11 few studies have explored a possible link with suicide.One study found no association. 12A more recent report noted an association between visual impairment and suicidal ideation. 13Neurological disorder was associated with suicide in our study, paralleling findings from register studies on mixed age populations. 14e observed an increased rate of suicide in people with ongoing malignant disease, which agrees with results of studies of mixed age 15 and elderly 16 populations.Cardiovascular disease and musculoskeletal disorders have been reported as common among elderly people who committed suicide. 2 The case-control design allowed us to show that these disorders were not risk factors for suicide.Many elderly people who commit suicide consult their doctor a short time before their death, 17 but many fail to communicate their despair.We have recently shown that relatives observed suicidal feelings twice as frequently as doctors, and doctors were less likely to discuss suicidal feelings with patients in poor physical health. 18Further research should focus on the detection and treatment of depression and suicidal ideation in the context of physical disease.We thank the informants and the control participants who made this study possible.We thank Dr Mark Miller for instruction regarding the cumulative illness rating scale; Eva Johansson and Christina Andersson for the interviews; Marina Johansson
Fifteen-year survival with prostate cancer in Sweden
Authors: G. Aus
Journal: JAMA (1997)

<h3>To the Editor.</h3> —Dr Johansson and colleagues<sup>1</sup>present data from Örebro County in Sweden with a very favorable 15-year outcome for untreated prostate cancer which, if they are correct, would have tremendous effects on the treatment of localized prostate cancer. However, the study suffers from a bias of unknown nature resulting in a survival twice as high as expected. Because of good access to health care in Sweden, almost all patients who later die from prostate cancer are diagnosed during their lifetime; ie, they emerge with clinical disease in different stages before death. A high diagnostic activity can be expected to diagnose more patients in early clinical stages while a low diagnostic activity leads to diagnosis of more advanced tumors. When curative treatment is not practiced, the absolute number of patients who die from prostate cancer within 1 geographic area is largely independent of the diagnostic activity. From official
C/EBPε mediates nicotinamide-enhanced clearance of Staphylococcus aureus in mice
Authors: Pierre Kyme, Nils H. Thoennissen, Ching Wen Tseng, Gabriela B. Thoennissen, Andrea J. Wolf, Kenichi Shimada, Utz O. Krug, Kunik Lee, Carsten Müller-Tidow, Wolfgang E. Berdel, W. David Hardy, Adrian F. Gombart, H. Phillip Koeffler, George Y. Liu
Journal: Journal of Clinical Investigation (2012)
Steroid Causes Muscle Changes in Rabbits
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hemodynamic and Morphologic Alterations in Experimental Portal Hypertension from Blood Overflow
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Integrated analysis of serum immunological biomarkers in patients with chronic hepatitis C upon direct-acting antiviral treatment
Authors: Isabela Gomes Ribeiro, Ismael Artur Costa-Rocha, Andrea Teixeira-Carvalho, Luciana Diniz Silva, Ana Carolina Campi-Azevedo, Olindo Assis Martins-Filho, Rosângela Teixeira
Journal: Journal of Hepatology (2020)
A gentic trip
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Treatment of chronic hepatitis C with recombinant human interferon-α2a: Results of a randomized controlled clinical trial
Authors: G Diodati
Journal: Hepatology (1994)

Sixty consecutive patients with chronic hepatitis C were included in a randomized controlled trial of recombinant human interferon-α2a vs. no treatment. Treated patients received tapering doses of interferon thrice weekly for 1 yr. Twenty treated cases (66.7) normalized serum aminotransferase levels within the first 4 mo of treatment, but reactivation or breakthrough frequently occurred afterward (20 in both cases). Only one of the untreated patients showed spontaneous normalization of serum aminotransferase levels. Liver histology did not improve in patients without a biochemical response or with breakthrough during therapy, whereas it did not worsen in long-term responders and reactivating patients. Lack of response does not appear to be related to serum interferon antibodies, although their early appearance is more frequent in patients who showed reactivation later on. No biochemical parameter was found to be predictive for positive response to treatment. Antibody to c100 became negative in 62.5 of long-term responders, whereas no change was recorded in other treated patients or controls. Reactivation and breakthrough often occur during treatment, and further studies are needed to determine the most effective schedule (dose and time) of interferon treatment. Loss of c100 antibody during therapy may be a marker of long-term maintenance of response to interferon therapy. (Hepatology 1994;19:1–5).
The prevalence of esophageal varices needing treatment depends on gender, etiology and BMI
Authors: Arthur Berger, Federico Ravaioli, Oana Nicoara-Farcau, Davide Festi, Horia Stefanescu, Pierre Nahon, Christophe Bureau, Nathalie Ganne-Carrié, Annalisa Berzigotti, Victor de Lédinghen, Salvatore Petta, Paul Cales
Journal: Journal of Hepatology (2020)
Abstracts Presented at the 60th Annual Meeting of the SW Chapter, SNMMI
Journal: Clinical Nuclear Medicine (2016)

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Prenatal alcohol exposure affects galactosyltransferase activity and glycoconjugates in the Golgi apparatus of fetal rat hepatocytes
Authors: J Renau-Piqueras
Journal: Hepatology (1997)

Prenatal exposure to alcohol affects the morphological, structural, and functional features of the Golgi apparatus (GA), thus altering the glycosylation process in fetal hepatocytes. To elucidate the cellular mechanisms underlying these alterations, we have studied the effect of alcohol exposure in utero on the activity of liver galactosyltransferase, an enzyme involved in the glycosylation process, and on the hepatic glycoprotein sugar composition. For this, livers from 21-day-old fetuses obtained from control and ethanol-fed rats were used. Galactosyltransferase (GT) activity was determined in isolated GA cis and trans fractions. Colloidal gold-labeled lectin cytochemistry was used to analyze sugar residues in hepatocytes at the subcellular level. Finally, the integrity of the GA after alcohol treatment was assessed by electron microscopy and by evaluating the distribution of the Golgi β-COP, a protein involved in vesicular trafficking. Prenatal alcohol exposure induces a significant increase in both liver weight and total protein content in the trans Golgi. Moreover, this treatment decreases the activity of galactosyltransferase, increases α-L-Fuc residues, and reduces the number of α-Man, GlcNAc(β1,4,GlcNAc)1,2, GalNAc α1,3GalNAc, α-GalNAc, and a-Gal residues. Alcohol exposure also causes the Golgi cisternae to disappear in about 30% of the hepatocytes, and reduces 75% the number of anti-Golgi β-COP protein binding sites. Our results suggest that the decrease in galactosyltransferase activity, the alterations in the oligosaccharide chain composition, and the reduction in the amount of Golgi β-COP protein could be involved in the alterations in the glycosylation process, as well as in the accumulation of hepatic proteins observed after prenatal alcohol exposure. These alterations could contribute, therefore, to the alcohol-induced injury in the developing liver.
P17.41 * CLINICAL MANAGEMENT AND OUTCOME OF HISTOLOGICALLY VERIFIED ADULT BRAINSTEM GLIOMAS IN SWITZERLAND: A RETROSPECTIVE ANALYSIS OF 21 PATIENTS
Authors: T. Hundsberger, M. Tonder, H. Andreas, D. Brugge, U. Roelcke, P. M. Putora, R. Stupp, M. Weller
Journal: Neuro-Oncology (2014)

BACKGROUND: Because of low incidence, mixed study populations and paucity of clinical and histological data, the management of adult brainstem gliomas remains non-standardized. We here describe characteristics, treatment and outcome of patients with exclusively histologically confirmed adult brainstem gliomas. METHODS: A retrospective chart review of adults (>age 18 years) was conducted. Brainstem glioma was defined as a glial tumor located in the midbrain, pons or medulla. Characteristics, management and outcome were analyzed. RESULTS: 21 patients (17 males; median age 41 years) were diagnosed between 2004 and 2012 by biopsy (n = 15), partial (n = 4) or complete resection (n = 2). Diagnoses were glioblastoma (WHO grade IV, n = 6), anaplastic astrocytoma (WHO grade III, n = 7), diffuse astrocytoma (WHO grade II, n = 6) and pilocytic astrocytoma (WHO grade I, n = 2). Diffuse gliomas were mainly located in the pons and frequently showed MRI contrast enhancement. Endophytic growth was common (16 versus 5). Postoperative therapy in low-grade (WHO grade I/II) and high-grade gliomas (WHO grade III/IV) consisted of radiotherapy alone (3 in each group), radiochemotherapy (2 versus 6), chemotherapy alone (0 versus 2) or no postoperative therapy (3 versus 1). Median PFS (24.1 versus 5.8 months; log-rank, p = 0.009) and mOS (30.5 versus 11.5 months; log-rank, p = 0.028) was significantly better in WHO grade II than in WHO grade III/IV tumors. Second-line therapy considerably varied. CONCLUSIONS: Histologically verification of adult brainstem glioma is feasible and has an impact on postoperative treatment. Low-grade gliomas can simple be followed or treated with radiotherapy alone. Radiochemotherapy with temozolomide can safely be prescribed for high-grade gliomas without additional CNS toxicities.
ANTHROPOMETRY IN NATIONAL EVOLUTION.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Should We Be Vaccinated? A survey of the Controversy in Its Historical and Scientific Aspects.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Highlights from this issue
Journal: Thorax (2017)

The TriumvirateOn 8 June, this year, voters in the United Kingdom will select their members of parliament (MPs) for 650 constituencies-lets hope they choose wisely.In this edition of Airwaves, we offer you an election special of politically themed recommendations from Thorax.We hope these are informative, challenging and a welcome antidote to pre election and post election punditry.
THE ABUNDANT LIFE
Authors: J. R. E.
Journal: Annals of Internal Medicine (1961)

Editorials1 June 1961THE ABUNDANT LIFEJ. R. E.J. R. E.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-54-6-1300 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMens sana in corpore sano—a sound mind in a healthy body—is the goal of our endeavors as physicians, for ourselves as well as for our patients. The paths to this goal are usually harder to see than the goal itself; the literature of the world is replete with recipes for happiness. And not only are the methods of procedure many but the goal itself is varied. In earlier days and in primitive societies the chief objective used to be just to stay alive; a recent cartoon in theSaturday Reviewshows a native against a background of Floridian swamp and... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1961Volume 54, Issue 6Page: 1300-1301KeywordsHappiness ePublished: 1 December 2008 Issue Published: 1 June 1961 PDF downloadLoading ...
Contents
Authors: Richard Blanch, Peter Good, Peter Shah, Jon Bishop, Ann Logan, Robert Scott, Martin Zinkernagel, Markus Groppe, Robert Maclaren, Timothy Jackson, Pravin Dugel, Judith Bebchuk, Kelly Smith, Robert Petrarca, Jason Slakter, Glenn Jaffe, Jeffrey Nau, Emily Chew, Traci Clemons, Elvira Agrón, Robert Sperduto, John Sangiovanni, Natalie Kurinij, Matthew Davis, Samir Khandhadia, Svetlana Hakobyan, Ling Heng, Jane Gibson, David Adams, Graeme Alexander, Jonathan Gibson, Keith Martin, Geeta Frcophth, Kathryn Frcophth, Sobha Sivaprasad, Sarah Ennis, Angela Cree, B Morgan, Andrew Fmedsci
Journal: Ophthalmology (2013)
More choices in treating AIDS-related pneumonia
Authors: R. Voelker
Journal: JAMA (1994)

THE NEWEST weapon against<i>Pneumocystis carinii</i>pneumonia (PCP) is the antifolate trimetrexate glucuronate. After nearly 8 years in development as a treatment for PCP, the drug received Food and Drug Administration (FDA) marketing approval late last month. Pharmaceutical maker US Bioscience Inc, West Conshohocken, Pa, will market it under the brand name NeuTrexin. Approval of the drug is an important development for the 80% of AIDS patients who require treatment for PCP, says Robert Capizzi, MD, executive vice president of research and development at Bioscience. But company officials and researchers involved in clinical trials of trimetrexate note that its main value is as a salvage medication rather than a drug of choice for PCP. It is indicated for patients who cannot tolerate the combination of trimethoprim and sulfamethoxazole (TMP/SMX). Trimetrexate works by inhibiting dihydrofolate reductase (DHFR), the enzyme that both healthy human cells and<i>P carinii</i>require for metabolism and
Informing physicians about promising new treatments for severe illnesses
Authors: R. Steinbrook
Journal: JAMA (1990)

Physicians are increasingly informed of promising new treatments for severe illnesses through unconventional communications such as press releases, press conferences, and direct mailings. These highly publicized announcements disseminate information quickly, often many months before new data are presented at medical meetings or published in peer-reviewed medical journals. Such unconventional communications, however, usually do not provide sufficient detail for physicians to evaluate new studies, answer patients' questions, or make recommendations. We suggest that physicians would be better informed about therapeutic advances through (1) expanded information in unconventional communications, (2) increased availability of information from the Food and Drug Administration, (3) early submission and accelerated review of key medical journal articles, and (4) expanded use of on-line computerized information sources. A commitment to inform physicians better about promising new treatments may help save or prolong the lives of patients with severe illnesses. (<i>JAMA</i>. 1990;263:2078-2082)
PURE MILK AND INFANT MORTALITY.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal