tbuckley/cabot-search huggingface dataset:
NCCTG N0574 (Alliance): A phase III randomized trial of whole brain radiation therapy (WBRT) in addition to radiosurgery (SRS) in patients with 1 to 3 brain metastases.
Authors: Paul D. Brown, Anthony L. Asher, Karla V. Ballman, Elana Farace, Jane H Cerhan, S. Keith Anderson, Xiomara W. Carrero, Frederick G. Barker, Richard L. Deming, Stuart Burri, Cynthia Menard, Caroline Chung, Volker W. Stieber, Bruce E. Pollock, Evanthia Galanis, Jan C. Buckner, Kurt A. Jaeckle
Journal: Journal of Clinical Oncology (2015)

LBA4 The full, final text of this abstract will be available at abstracts.asco.org at 7:30 AM (EDT) on Sunday, May 31, 2015, and in the Annual Meeting Proceedings online supplement to the June 20, 2015, issue of the Journal of Clinical Oncology. Onsite at the Meeting, this abstract will be printed in the Sunday edition of ASCO Daily News.
THE PERIPATETIC PROFESSOR
Journal: JAMA (1961)

A Chair in a medical school is considered to be a relatively stable professional position. A few notable exceptions come to mind. Hans Zinsser migrated from the Department of Bacteriology at Stanford to the College of Physicians and Surgeons of Columbia University in New York, and later to Harvard Medical School. William H. Welch remained on the eastern seaboard, moving from Bellevue Hospital Medical College to Johns Hopkins University. One of the most notable examples of a roving professor was Austin Flint, a warm friend of Welch's, who held positions in six medical schools. Flint was one of the outstanding professors of medicine in the mid-portion of the 19th century. He holds particular interest for me for several reasons. Following graduation from Harvard Medical School at the age of 21, he practiced medicine in Boston and Northampton, Mass, for three years. He then moved to Buffalo, established a new practice,
Catholic Churchmen in Science. Sketches of the Lives of Ecclesiastics Who Were Among the Great Founders in Science.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hydroxychloroquine-induced vertigo
Authors: D. S. Prince
Journal: JAMA (1975)

SEVERE vertigo occurred in a patient receiving hydroxychloroquine sulfate in usual dosage. The reaction was confirmed by rechallenge therapy. <h3>Report of a Case</h3> A 54-year-old woman was seen at the University of Alabama in Birmingham Hospitals for chronic, destructive seronegative rheumatoid arthritis. She was treated with prednisone, 10 mg, and 16 aspirin (300-mg tablets) daily. Because of a skin rash, administration of gold sodium thiomalate was discontinued, and therapy with hydroxychloroquine sulfate was begun at a dose of 400 mg daily by mouth. After three days of therapy, she experienced a severe, generalized headache without visual or auditory aura. During the next three days, blurred vision, unsteady gait, severe nausea, and severe positional vertigo were noted. Nausea and vertigo were worsened by the slightest head motion and were somewhat relieved by lying still with eyes closed. The results of a physical examination when the patient was hospitalized disclosed nystagmoid eye
CA184-156: Randomized, multicenter, double-blind, phase III trial comparing the efficacy of ipilimumab (Ipi) plus etoposide/platinum (EP) versus placebo plus EP in patients (Pts) with newly diagnosed extensive-stage disease small cell lung cancer (ED-SCLC).
Authors: Joachim Von Pawel, Sang-We Kim, David R. Spigel, Christoph Zielinski, Maria Catherine Pietanza, Veerle de Pril, Marc S. Ballas, Martin Reck
Journal: Journal of Clinical Oncology (2013)

TPS7608 Background: Phase III studies have not reported improvement for ED-SCLC beyond EP. Moreover, chemotherapeutic response in SCLC is short-lived, with a median survival of 8–12 months and 5-year survival rates ranging from 1%–2%. Ipi, a fully human monoclonal antibody which binds CTLA-4, augments antitumor immune responses and may potentially improve the clinical benefit of EP. A randomized phase II study of Ipi + paclitaxel/carboplatin (PC) in pts with ED-SCLC showed significant improvement in progression-free survival (PFS) [measured by immune-related response criteria (irRC)] over PC in pts receiving phased Ipi + PC; irRC were derived from WHO criteria to better capture response patterns observed with Ipi. Addition of Ipi trended toward prolonged overall survival (OS) and did not exacerbate PC toxicity; immune-related adverse events were managed using protocol-specific guidelines. This global (~227 sites among 34 countries), multicenter phase III study in pts with ED-SCLC (ClinicalTrials.gov identifier NCT01450761) will determine if adding Ipi to EP increases OS vs EP alone. Methods: Pts with first-line ED-SCLC and ECOG 0-1 will be eligible; pts with a history of autoimmune disease will be ineligible. Pts will be randomized (1:1 to either Arm A or Arm B) to 2 cycles of EP (etoposide [100 mg/m 2 , IV on Days 1-3 Q3W] and cisplatin [75 mg/m 2 , IV] or carboplatin [AUC=5, IV] once Q3W), followed by 4 cycles of blinded study drug (Ipi 10 mg/kg, IV in Arm A or placebo in Arm B, Q3W) with 2 concurrent cycles (during cycles 3-4) of EP and Ipi (6 cycles of total therapy). Eligible pts will receive Ipi maintenance therapy Q12W until disease progression or unacceptable toxicity; pts with a complete response will also be eligible for prophylactic cranial irradiation at investigator’s discretion. The primary endpoint is OS; secondary endpoints include OS among pts who receive blinded therapy, immune-related and mWHO PFS, best overall response rate, and duration of response. The trial will also characterize safety, and is estimated to enroll 1100 pts. Clinical trial information: NCT01450761.
Abstract 19055: MicroRNA Gene Expression of Heart Transplant Endomyocardial Biopsy
Authors: Eleanor Chang, Gregory Fishbein, Maral Bakir, Galyna Bondar, Nicholas Jackson, David Liem, Silvio Litovsky, Jose Tallaj, Charlotte Starling, Peipei Ping, Elaine Reed, Mario Deng, Esteban Tabak, Martin Cadeiras
Journal: Circulation (2015)

Introduction Endomyocardial biopsy is the standard surveillance method to detect cardiac allograft rejection. While microRNAs (miRNA) play a major role in regulating mRNA, their nature and role in the biology is not well understood. We hypothesized that specific mRNA-miRNA networks can be identified underlying the clinical phenotypes of different forms of cardiac allograft rejection. Method Twenty one tissue samples from 14 post-HTx patients were subjected to genome wide miRNA sequencing. A non-parametric empirical Bayes framework removed batch effect and filtered genes with low variability. Weighted Gene Correlation Network Analysis (WGCNA) clustered genes into related eigengene modules based on their gene expression. Identified miRNAs were subjected to target prediction and compared with mRNA expression profiles previously identified on the same biopsies. Gene Ontology (GO) was used for biological interpretation of selected genes. Results 1270 miRNAs were used to construct 9 eigengene modules. Module-Trait relationship were then investigated as shown in Figure. The top ten miRNA probe sets filtered by the highest intra-module correlation and statistical significance were hsa-miR-141-3p, hsa-miR-150-5p, hsa-miR-605, hsa-miR-582-5p, hsa-miR-3150b-3p, hsa-miR-508-3p, hsa-miR-652-5p, hsa-miR-26a-1-3p, hsa-miR-3667-3p and hsa-miR-3911. Target prediction analysis resulted in 724 gene targets. GO analysis revealed 184 categories enriched by these genes including regulation of protein kinase activity, cardiac muscle cell differentiation and epithelial cell migration among others. Compared to mRNA previously identified in the same heart biopsies showed 685 overlapping gene targets. Conclusion WGCNA identified miRNA modules correlated with different clinical phenotypes of rejection. MRNA-miRNA pairs were identified to help understand the biology of rejection and as interesting candidates for diagnostic or therapeutic applications.
Nutritional Assessment of Children in Drought-Affected Areas—Haiti, 1990
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Helen Bawtree
Authors: J. Bawtree
Journal: BMJ (2014)

The treatment of anisometropic or ametropic amblyopia has traditionally enjoyed a high treatment success rate. Early initiation and consistent use of spectacle correction can completely resolve amblyopia in a majority of patients. For those with anisometropic amblyopia that fail to improve with glasses wear alone, patching or atropine penalisation can lead to equalisation of visual acuity. However, successful treatment requires full-time compliance with refractive correction and this can be a challenge for a patient population that often has one eye with good acuity without correction. Other barriers for a select population with high anisometropic&nbsp; or ametropic amblyopia include rejection of glasses for various reasons including discomfort, behavioural or sensory problems, postural issues and visually significant aniseikonia.&nbsp;When consistent wear of optical correction proves difficult and patching/atropine remains a major obstacle, surgical correction of refractive error has proven success in achieving vision improvement. Acting as a means to achieve spectacle independence or reducing the overall needed refractive correction, refractive surgery can offer a unique treatment option for this patient population. Laser surgery, phakic intraocular lenses and clear lens exchange are three approaches to altering the refractive state of the eye. Each has documented success in improving vision, particularly in populations where glasses wear has not been possible.&nbsp;Surgical correction of refractive error has a risk profile greater than that of more traditional therapies. However, its use in a specific population offers the opportunity for improving visual acuity in children who otherwise have poor outcomes with glasses and patching/atropine alone.
Digital Gangrene
Authors: Hugh H. Hussey
Journal: JAMA (1976)

The development of tissue necrosis of the tips of fingers and toes suggests Raynaud disease or Raynaud phenomenon. The latter is sometimes the signal manifestation in varied diseases, including scleroderma, pneumatic hammer disease, scalenus anticus syndrome, cervical rib, shoulder-hand syndrome (reflex sympathetic dystrophy), peripheral arterial disease (arteriosclerosis, thromboangiitis obliterans), drug poisoning (ergot, methysergide), and several hematologic disorders in which exposure to cold causes sludging of blood. Three recent reports in publications of the American Medical Association present other causes for consideration. In the current issue of<i>Archives of Internal Medicine</i>(136:1273-1280, 1976), Gipstein and his colleagues describe 11 patients with chronic renal insufficiency owing to various causes, who, while under treatment by long-term hemodialysis (five cases) or by functioning homotransplants (six cases), developed livedo reticularis and painful ischemic ulcers of the fingers or toes or both. In some cases, cutaneous necrosis also appeared in other areas of the lower extremities.
Exploratory Monitoring of Air Pollutants for Mutagenicity Activity with the Tradescantia Stamen Hair System
Authors: L. A. Schairer, J. Van't Hof, C. G. Hayes, R. M. Burton, F. J. de Serres
Journal: Environmental Health Perspectives (1978)

The Tradescantia genetic system developed by the late Dr. Arnold H. Sparrow for the study of effects of ionizing radiation is applicable to chemical mutagen detection. Early radiobiological data demonstrated that the stamen hairs were sensitive to as little as 0.25 rad of x-rays and that the number of cells showing a phenotypic change in pigmentation from blue to pink plateaus after approximately 21 days of chronic, low-level irradiation. Exposures to the air pollutants SO2, NO2, and O3 and to vapors of mutagens such as 1,2-dibromoethane (DBE) and ethyl methanesulfonate (EMS) demonstrated the usefulness of the system as a detector of chemical mutagens. A significant number of phenotypic changes was observed following exposures to as little as 0.14 ppm of DBE. The maximum sensitivity of the system is obtained with long-term or chronic exposures because the response increases linearly in proportion to the duration of exposure up to 21 days. To monitor industrial sites for atmospheric mutagens a mobile laboratory was designed to support plant culture in the field. Environment-controlled growth chambers were installed in a trailer so that both ambient air fumigations and concurrent clean-air control exposures could be made. Sites monitored by the mobile laboratory were: Elizabeth, N. J.; Charleston, W. Va.; Birmingham, Ala.; Baton Rouge, La.; Houston, Tex.; Upland, Calif.; Magna, Utah; and Grand Canyon, Ariz. The latter site at Grand Canyon served as a clean air control study. Atmospheric contaminants from petroleum and chemical processing plants generated a significant number of phenotypic pigment changes that were 17 to 31% above the control levels; contaminants from steel and copper smelters, automotive combustion products and photochemical compounds were negative. Chemical analyses are underway to identify the atmospheric mutagens at the sites that showed a positive response.
ELECTRONIC REACTIONS
Authors: R. S. Minerd
Journal: JAMA (1923)

<h3>To the Editor:</h3> —I have been much interested in the article appearing in a recent issue (July 28) ofThe Journalon the case of carcinoma of the stomach treated by the Abrams method. It is almost exactly a parallel of a case that occurred in Erie a few months ago. The patient refused to be operated on, but allowed an osteopath to let him die in agony by the Abrams route. The Erie County Medical Society has expelled two members for their refusal to give up their activities in this farce. They, Drs. C. B. Lininger and Ellen Walker-Berry, with four osteopaths, are frantically waving the Abrams banner in Erie. The people are gradually learning, via undertakers and ruptured bank accounts, the "wonders" of the quackery.
A Phase 2 Study of Peginterferon Lambda, Lonafarnib and Ritonavir for 24 Weeks: End-of-Treatment Results from the LIFT HDV Study
Authors: Christopher Koh, Julian Hercun, Farial Rahman, Amy Huang, Ben Da, Pallavi Surana, Devika Kapuria, Yaron Rotman, Anusha Vittal, Christy Ann Gilman, Gil Ben Yakov, Walter Lai, Harel Dahari, Jeffrey Glenn, Theo Heller
Journal: Journal of Hepatology (2020)
The synthesis rates of total liver protein and plasma albumin determined simultaneously in vivo in humans
Authors: H Barle
Journal: Hepatology (1997)

Although the metabolism of liver-derived plasma proteins such as albumin has been extensively studied, human hepatic protein synthesis as a whole has not been well characterized, because a reproducible model for obtaining human liver tissue has not been available. In this study, the fractional synthesis rates of total liver protein and albumin in vivo were determined simultaneously in nine subjects undergoing elective laparoscopic cholecystectomy. L-[2H5]phenylalanine (45 mg/kg body wt) was administered for 10 minutes intravenously. Blood samples were collected at regular intervals for 90 minutes and a liver biopsy specimen was taken at 35 +/- 7 minutes. The enrichments of plasma free phenylalanine, plasma albumin, and total liver protein were measured with gas chromatography mass spectrometry (GC-MS). The fractional synthesis rate (FSR) of total liver protein was 24.7 +/- 3.1 %/d (mean +/- SD), and that of albumin was 5.9 +/-1.2%/d. The amount of albumin synthesized per day (absolute synthesis rate, ASR) was 109 +/- 21 mg/kg body wt. No correlation between FSR of total liver protein and ASR of albumin was found. It is concluded that the technique of obtaining liver tissue specimens during laparoscopic surgery may serve as a human in vivo model to study total liver protein synthesis. The fractional synthesis rate of total liver proteins (stationary and exported), equals approximately 25% of the liver protein content daily. Within the range of values of this study, the absolute synthesis rate of albumin was not correlated to the fractional synthesis rate of total liver protein. (Hepatology 1997 Jan;25(1):154-8)
Auranofin/Vitamin C: A Novel Drug Combination Targeting Triple-Negative Breast Cancer
Authors: Elie Hatem, Sandy Azzi, Nadine El Banna, Tiantian He, Amélie Heneman-Masurel, Laurence Vernis, Dorothée Baïlle, Vanessa Masson, Florent Dingli, Damarys Loew, Bruno Azzarone, Pierre Eid, Giuseppe Baldacci, Meng-Er Huang
Journal: JNCI Journal of the National Cancer Institute (2018)

Cancer cells from different origins exhibit various basal redox statuses and thus respond differently to intrinsic or extrinsic oxidative stress. These intricate characteristics condition the success of redox-based anticancer therapies that capitalize on the ability of reactive oxygen species to achieve selective and efficient cancer cell killing.
Heart Health in the Workplace
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
From the editors
Authors: Frédéric Geissmann, Siamon Gordon, Chen Varol, Ehud Zigmond, Vincenzo Bronte, Dmitry Gabrilovich, Lucy Bird, Kirsty Minton, Olive Leavy, Yvonne Bordon, Gemma Ryan, Man Tse, Simon Bradbrook, Susanne Harris, Vicky Summersby, Patrick Managing, Judith Shadwell, Simon Fenwick, Natalie Smith, Jacques Smit, Laura Corns, Deborah Anthony, Marketing Managers, Tim Redding, Leah Rodriguez
Journal: Nature reviews. Immunology (2010)
A simple modification in operative technique can reduce the incidence of nonanastomotic biliary strictures after orthotopic liver transplantation
Authors: H SANKARY
Journal: Hepatology (1995)

Nonanastomotic strictures after liver transplantations are a source of significant morbidity, often necessitating retransplantation. The purpose of this study was twofold: first to identify features associated with the development of this lesion; second, to make technical modifications that will decrease the incidence of this problem. In the first part of this study, 15 of 131 patients were diagnosed with nonanastomotic biliary stricture. A stepwise logistic-regression analaysis associated donor cold ischemie time and dopamine dose with the development of nonanastomotic biliary strictures. All these patients had arterial reconstruction after partial revascularization of the liver with portal venous blood. Because the bile duct receives its blood supply from only the hepatic artery, we hypothesized staged reconstruction of the vascular supply would promote the development of this lesion. In a second a part of this study, the stricture rate in 45 patients with simultaneous revascularization using both the hepatic artery and portal vein was compared with that in 83 patients from the first part of this study, initially revascularized with portal venous blood. All patients in the second study had grafts preserved using UW solution. Only 1 patient with simultaneous revascularization developed a nonanstomotic biliary stricture. Because we were unable to identify any significant complications related to this method of revascularization, we propose that the hepatic artery and portal vein should be released simultaneously, especially in patients receiving a graft with prolonged storage time. (Hepatology 1995;21:63–69).
High-throughput Phenotyping of Lung Cancer Somatic Mutations
Authors: Alice H. Berger, Angela N. Brooks, Xiaoyun Wu, Yashaswi Shrestha, Candace Chouinard, Federica Piccioni, Mukta Bagul, Atanas Kamburov, Marcin Imielinski, Larson Hogstrom, Cong Zhu, Xiaoping Yang, Sasha Pantel, Ryo Sakai, Jacqueline Watson, Nathan Kaplan, Joshua D. Campbell, Shantanu Singh, David E. Root, Rajiv Narayan, Ted Natoli, David L. Lahr, Itay Tirosh, Pablo Tamayo, Gad Getz, Bang Wong, John Doench, Aravind Subramanian, Todd R. Golub, Matthew Meyerson, Jesse S. Boehm
Journal: Cancer Cell (2017)