tbuckley/cabot-search huggingface dataset:
Oral Vitamin K for Warfarin-Associated Coagulopathy
Authors: Mark A. Crowther
Journal: Annals of Internal Medicine (2003)

Letters1 April 2003Oral Vitamin K for Warfarin-Associated CoagulopathyMark A. Crowther, MD, MScMark A. Crowther, MD, MScSt. Joseph's Hospital; Hamilton, Ontario L8N 4A6, Canada (Crowther)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-138-7-200304010-00030 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Weideman and Patel raise a number of salient points. We agree that our results apply only to patients who receive the forms of vitamin K that we administered and should be confirmed if other formulations (such as tablets) are to be used. Furthermore, we agree that the relative times from administration of vitamin K to subsequent INR determinations are critical. In our study, these times were available for all but two patients and were very similar (23.5 vs. 23.0 hours in the oral and subcutaneous groups, respectively [P > 0.2]). Finally, although many medications are dosed according to ...Reference1. Crowther MA, Julian J, McCarty D, Douketis J, Kovacs M, Biagoni L, et al. . Treatment of warfarin-associated coagulopathy with oral vitamin K: a randomised controlled trial. Lancet. 2000;356:1551-3. [PMID: 11075768] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Mark A. Crowther, MD, MScAffiliations: St. Joseph's Hospital; Hamilton, Ontario L8N 4A6, Canada (Crowther) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoOral Vitamin K Lowers the International Normalized Ratio More Rapidly Than Subcutaneous Vitamin K in the Treatment of Warfarin-Associated Coagulopathy Mark A. Crowther , James D. Douketis , Terri Schnurr , Luigi Steidl , Valentina Mera , Carolina Ultori , Achille Venco , and Walter Ageno Oral Vitamin K for Warfarin-Associated Coagulopathy Rick Weideman and Amit P. Patel Oral Vitamin K for Warfarin-Associated Coagulopathy Elin Ringstrom and Heather Long Metrics 1 April 2003Volume 138, Issue 7Page: 611KeywordsAlcoholsAtrial fibrillationBody weightCoagulopathyDeep vein thrombosisInternational normalized ratioLiverProphylaxisVitamin K ePublished: 1 April 2003 Issue Published: 1 April 2003 Copyright & PermissionsCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Why prisoners volunteer to be experimental subjects
Authors: J. C. McDonald
Journal: JAMA (1967)

Recently, while engaged in a clinical experiment, involving inmates of a nearby state prison, I became rather perplexed by the reaction of colleagues to the program. There was considerable interest in why inmates subjected themselves to such experimentation. The question most frequently raised concerned what rewards were given to such volunteers, and the prevailing attitude seemed to be that this was a group of men who were simply being exploited, albeit for a good cause. This attitude is understandable coming from one whose viewpoint stems from a rather comfortable position in society, but the view is entirely different when it comes from within the walls of prison. In the flurry of current concern over the proper ethical guidelines of human experimentation, the rights of the subject to be protected have received attention as has the right of society for progress. I have not seen any discussion of the right of
Nervöse Herzerkrankungen u. ihre Behandlung.
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Practical Observations on Some of the More Important Points Connected with Physical Diagnosis
Authors: C. M. Durrant
Journal: BMJ (1845)

Notwithstanding that many of the phenomena de- ducible from the physical examination of the circula- ;qry Appar,;ps are less dqfnite aad precise an ho,,pertainng to tbe ogans of respiration, chiefly, poanhaps bec3Fl" -foauuet are less aumerpus, and iecpg,plwih Seater diiqpl1y tha* -the 1tters i4l1 it must be admitted, that the relative value Qf aw is the same, and conequently, shat the physical diagnoss oE!ditsse of he hearts equally with thoe of theluags, cl-aM.-simflarly,carefulapd searching ;investigation..,Tejrecutionr necessary so be observed in con- 4ingeaza eXtinnation of the cardiac region, do not arly .differ (ro those psevioualy laid down, whr.efWr 9gto * Re 4rg"u of respirati 'r -Insure .atiAeetofyresu4t, attention to the f0lowing circumstances becomes more or less impera- tive:"-st, Perfect quietude, both in.regard to tbe patient and surrounding noises, save, when it becomeg occasionally desirable, with a view of rendering the characterm more distinct, that the patient, if able, be directed to walk briskly for a few minutes up and Own the room, by which means, the pulsation of the heart-becoming quicker, the previously indistinct phomena will be more fully pronounced.2nd.That the chest, if possible, be bare, or, it covered, that the matenial be of the thinnest texture, and not flannel.3rd.That the patient be submitted to examination, bwth in the recumbent and sitting posture; this will be espedally indicated in the case of pericardial effusion.4th.That the indiridual be directed from time to time to suspend his breathing for a few moments, in order clearly to distinguish the sounds of tlw heart from certain abnormal phenomena, perbance peaniang to the respiration.5th.That the observer take time in the exploration, refraining with decision, in the eveat of the slightest doubt, from hazarding an opinion upon a single exanination.
Adolescent Medicine
Authors: Elizabeth R. McAnarney
Journal: JAMA (1986)

Primary -L rimary care practitioners are being challenged to provide preventive and curative services to adolescents. Adolescent health services are ideally provided by physicians knowledgeable about normal adolescent growth and development, the practice of adolescent medicine, and the causes of major morbidity and mortality in this age group.<sup>1</sup> Under the influence of hypothalamic, pituitary, adrenal, and gonadal hormones, physical growth during adolescence is dramatic.<sup>2</sup>Psychological development during adolescence is equally dramatic. Early adolescents (10 to 14 years of age) are focused on the present, in marked contrast to late adolescents (17 to 20 years of age), who usually have attained the cognitive capacity to think ahead about their personal, sexual, and vocational identities. Middle adolescents (14 to 17 years old) are in transition between the stages of early and late adolescence and usually present the greatest challenge because of their struggle with independence, autonomy, and identity.<sup>3</sup> Confidentiality
Kidney Transplantation: Mechanisms of Rejection and Acceptance
Authors: Lynn D. Cornell, R. Neal Smith, Robert B. Colvin
Journal: Annual Review of Pathology Mechanisms of Disease (2007)

We describe the molecular and cellular mechanisms believed to be responsible for the rejection of renal allografts, including acute T cell–mediated rejection, acute antibody-mediated (humoral) rejection, rejection mediated by the innate immune system, and chronic rejection. We present mechanisms of graft acceptance, including accommodation, regulation, and tolerance. Studies in animals have replicated many pathologic features of acute and chronic rejection. We illuminate the pathogenesis of human pathology by reflection from experimental models.
JOURNALISTIC NOTES.
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An Outpatient Operation for Hydrocele of the Tunica Vaginalis in Adults
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Chemoprophylaxis against Neisseria Meningitidis. The role of countercurrent immunoelectrophoresis
Authors: L. K. Pickering
Journal: JAMA (1976)

THE DIAGNOSIS of<i>Neisseria meningitidis</i>meningitis usually requires 48 to 72 hours for isolation and identification of the organism and serotyping to be performed. Determination of antimicrobial susceptibility takes an additional 24 to 48 hours. Moreover, many hospital laboratories are not equipped to perform proper sensitivity testing, resulting in further delay. Thus, these factors retard the prompt institution of specific antimicrobial chemoprophylaxis of household contacts. The choice of antibiotic depends on the serogrouping and antimicrobial sensitivity of the organism isolated from the index case. Following is a report of three patients with<i>N meningitidis</i>meningitis, two of whom were friends in whom the disease developed within the same week due to different serogroups. Countercurrent immunoelectrophoresis (CIE) provides a rapid and reliable method of diagnosing meningococcal meningitidis, allowing prompt and appropriate therapy for the index case and immediate antimicrobial chemoprophylaxis for household contacts. <h3>Report of Cases</h3><h3>Case 1.—</h3> A 10-year-old girl
Alteration of physicians' orders by nonphysicians
Authors: A. F. Finn
Journal: JAMA (1988)

We prospectively evaluated the accuracy with which clerical and laboratory staff carried out physicians' written orders for thyroid function testing in 181 patients at two institutions. In 54% of the patients studied, support staff were found to have added or deleted one or more tests from the original written orders. When the ordering physicians were asked to identify the clinical indications for the tests they had ordered, 37% of their orders either lacked an appropriate test or included an unnecessary test request. In contrast, after clerical and laboratory staff had changed orders, only 25% of patients had inappropriate tests performed or necessary tests omitted. Clerical staff using computer-based ordering menus significantly improved the appropriateness of physicians' orders compared with clerks who lacked such guidance. Laboratory technologists who used informal, knowledge-based rules also tended to improve the appropriateness of physicians' orders. We conclude that a substantial proportion of physicians' orders for diagnostic tests may be modified during the test requisitioning process. The use of testing regimens by ward clerks and laboratory technologists may explain their ability to improve on physicians' orders. (<i>JAMA</i>1988;259:2549-2552)
Rectal and pharyngeal gonorrhea in homosexual men
Authors: R. L. Owen
Journal: JAMA (1972)

To identify and treat rectal gonorrhea in male homosexuals, a physician took rectal, pharyngeal, and urethral specimens from all of his known homosexual patients. Of 26 patients with general medical complaints five had rectal gonorrhea, as did 19 of the 46 patients suspected of having this infection and two of seven with urethritis. Similar rectal symptoms occurred in those with and those without rectal gonorrhea, suggesting that symptoms are not directly related to gonorrheal infection. Pharyngeal cultures from 11 patients were positive for gonorrhea, but only three patients were symptomatic. Neither of two common regimens used for treatment in one visit (4,800,000 units of penicillin G procaine administered intramuscularly or 3 gm of tetracycline hydrochloride taken orally) was effective enough to use without follow-up cultures. Homosexuals are important carriers of gonorrhea; rectal and pharyngeal cultures are essential for diagnosis and treatment of these patients.
BUREAU OF INVESTIGATION
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Use of Information Technology in General Practice
Authors: Jason J Smith, Rebecca J Mallard-Smith, Victoria Beattie, David K Beattie
Journal: Journal of the Royal Society of Medicine (2003)

The internet and NHS Net are used increasingly in UK general practice. A questionnaire survey conducted in southern England examined these applications. 77 (55%) of 141 practices responded. Of these, 71 were connected to one or other service and 27 offered a practice website. Only a small minority used a website for direct patient booking or access to pathology results. Moreover, among those with a practice website, none paid the necessary attention to data security. The survey revealed some fundamental misunderstandings that may partly account for the slow uptake of these technologies in British general practice.
PROMOTER METHYLATION OF TUMOR SUPPRESSOR GENES ON THE SHORT ARM OF CHROMOSOME 1 IN MYELODYSPLASTIC SYNDROME AND ACUTE MYELOID LEUKEMIA
Authors: N. Mori, M. Ohwashi-Miyazaki, K. Yoshinaga, M. Shiseki, H. Sakura, J. Tanaka
Journal: HemaSphere (2019)
Correction: Maelstrom promotes hepatocellular carcinoma metastasis by inducing epithelial‐mesenchymal transition via Akt/GSK‐3β/snail signaling
Authors: Ling Zhang, Guannan Tang, Yuzhao Wang, Geng Xue, Shuhan Sun, Lulu Liu, Yongdong Dai, Jinna Chen, Tingting Zeng, Yan Li, Leilei Chen, Ying-Hui Zhu, Jiangchao Li, Stephanie Ma, Dan Xie, Yun-Fei Yuan, Xin-Yuan Guan
Journal: Hepatology (2016)
Abstract 2039: Urinary 8-Hydroxy-2′-Deoxyguanosine Levels Decrease After Cardioversion in Atrial Fibrillation
Authors: Takashi Uemura, Hiroshige Yamabe, Yasuhiro Nagayoshi, Yasuaki Tanaka, Kenji Morihisa, Hisao Ogawa
Journal: Circulation (2007)

Background : Atrial fibrillation (AF) has been shown to be associated with increased oxidative stress mediated by reactive oxygen species (ROS). Previous studies have proposed that there is a link between oxidative stress and AF, and thus oxidative stress may contribute to the pathological consequences of AF such as thrombosis, inflammation, and atrial tissue remodeling. Urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG) which is a product of deoxyribonucleic acid (DNA) damage by ROS has become to be regarded as a putative biomarker of oxidative DNA damage. Also, biopyrrins which are oxdative metabolites of bilirubin (an important scavenger of ROS) are considered as the potential marker of oxdative stress. In the present study, we assessed serial changes in oxidative stress in patients with AF after cardioversion by measuring urinary 8-OHdG and urinary biopyrrin excretion. Methods and Results : The study subjects consisted of 15 patients with persistent or chronic AF, who underwent electrical or pharmacological cardioversion. We measured urinary 8-OHdG and biopyrrin levels obtained before cardioversion and 24 hours after cardioversion using enzyme-linked immunosorbent assay. There was no significant difference in the biopyrrin/creatinine levels before and 24 hours after cardioversion (3.2±2.6 vs. 3.3±2.4 mU/mg, P=NS). However, 8-OHdG/creatinine levels decreased significantly 24 hours after cardioversion (18.4±9.1 vs. 14.7±8.5 ng/mg, P=0.0012). There was no significant correlation between urinary 8-OHdG/creatinine and biopyrrin/creatinine levels. This discrepancy may be related to the difference in the time course between urinary 8-OHdG/creatinine and biopyrrin/creatinine levels. Thus, measurement of 8-OHdG/creatinine levels seemed to be a more useful marker which reflects the oxidative stress than biopyrrin/creatinine levels at the time 24 hours after cardioversion. Conclusions : These findings suggest that the restoration of sinus rhythm by cardioversion decreases oxidative DNA damage in AF patients, and urinary 8-OHdG may be useful for the estimation of oxidative stress in AF patients. The increase of oxidative stress may play an important role in the pathogenesis of AF, and persist AF and result in the perpetuation of AF.
Prevalence and Pathogenesis of Pneumoconiosis in Coal Workers
Authors: Alfred G. Heppleston
Journal: Environmental Health Perspectives (1988)

Dust dose and composition do not appear to account wholly for changes in the prevalence of coal workers' pneumoconiosis in Europe. In certain coal pits high progression evidently occurred with relatively low dust exposure or vice versa, whereas progression in relation to dust levels might be variable. Exceptionally high quartz concentrations occur in coal mine dust when pneumoconiosis may progress with unusual rapidity. Under such circumstances lesions resembling silicotic nodules may be found, but with the customarily lower levels of quartz the pathological features assume the form characteristic of coal workers. Morphological changes in relation to dust content of human and animal lungs, as well as cellular behavior, have not accounted completely for the epidemiological findings. Considering all the pathological evidence helps explain the pathogenesis of pneumoconiosis and vagaries of progression. The origin of progressive massive fibrosis cannot be explained simply in terms of dust burden or immunological features, and the role of an infective factor cannot be dismissed. Moreover, lipid secretion by alveolar epithelium introduces a new element that could affect the development of simple and complicated pneumoconiosis. In vitro, cytotoxicity appeared to be too variable for predictive purposes, though direct assay of fibrogenicity using the macrophage fibrogenic factor suggested that dust dose was more important than dust composition. Assessing individual susceptibility presents serious obstacles.
Organophosphorus poisoning
Authors: R I Maynard, T C Marrs, M K Johnson
Journal: BMJ (1991)

methanesulphonate (P2S)) in a dose of 30 mg/kg body weight intravenously every four to six hours until full recovery.Although the importance of supportive measures and atropine cannot be underestimated, adults severely poisoned with organophosphorus com- pounds are likely to need 8-12 g pralidoxime daily for as long as the features of poisoning are present.So called "treatment failures" and "clinical re- lapses" after initial treatment with pralidoxime may well be due to inadequate oxime regimens, such as that proposed by Dr Hodgetts of only 2 g pralidoxime daily.Sustained therapeutic oxime concentrations could never be achieved in an adult by such a dosage regimen.In contrast, Dr Hodgetts advocates that very large doses ofatropine (2-4 mg every five to 10 minutes) should be given.Even in severe cases such high doses are likely to be required for only a short period if the patient is receiving adequate supportive care and effective oxime therapy.The contents of this lettcr represent the authors' views alone and in no wax commit the Department of Health.
Tall tales and imaginary companions
Authors: W. F. Gorman
Journal: JAMA (1975)

A CONSULTING psychiatrist would not be surprised to read of a woman in Virginia who was hypnotized by her husband and then gave a remarkable story, in rather poor German, that she was "Gretchen Gottlieb," a German girl who died 100 years ago under dramatic circumstances. But competent authorities were unable to verify the tale. It recalled the saga of Bridey Murphy. In 1952, a Colorado woman revealed under hypnosis that she was "Bridey," who lived and died in 19th century Ireland, but who turned out, alas, to be an unverified or a falsified character. There is nothing surprising about these stories, because all of us have a touch of the desire to prevaricate, which is rendered harmless almost all of the time in most of us by our conscious and unconscious controls. At one end of the spectrum, we see people who live a lie, falsifying and distorting any