tbuckley/cabot-search huggingface dataset:
Reconstitution of wild-type p53 gene in Hep3B cells using adenovirus-mediated transfer . Section of Hepatobiliary Diseases, University of Florida, Gainesville, FL; and MD Anderson Cancer Center1, University of Texas, Houston, TX
Journal: Hepatology (1995)

In human hepatocellular carcinoma (HCC), the high expression of urokinase-type plasminogen activator (uPA) is an unfavorable prognostic factor and a therapeutic target. To identify the downstream effects of uPA silencing by RNA interference, we studied proteome modifications of uPA-inhibited SKHep1C3 cells, an HCC-derived cell line. The study with two-dimensional difference gel electrophoresis and matrix-assisted laser desorption/ionization-time of flight-mass spectrometry showed Lim and SH3 protein 1 (LASP-1), cytokeratin 1 (CK-1), cytokeratin 10 (CK-10), and heterogeneous nuclear ribonucleoprotein H1 down-modulation after uPA inhibition. LASP-1, CK-1, and CK-10 are involved in cytoskeleton dynamics as heterogeneous nuclear ribonucleoprotein H1 takes part in the mRNA processing and stability. We first confirmed the proteomic data by Western blot and immunoflorescence and then explored the link between uPA and LASP-1. The ectopic expression of uPA and LASP-1 supported the proteomic results and showed that uPA up-regulation increased LASP-1 expression and that both were implicated in SKHep1C3 motility. siRNA LASP-1 inhibition showed that LASP-1 was involved in actin microfilaments organization of SKHep1C3 cells. The disruption of the actin microfilaments after LASP-1 depletion increased uPA secretion and SKHep1C3 motility. Our results would suggest the hypothesis that uPA and LASP-1 expression may be coordinated in HCC-derived cells. In summary, the proteomic identification of a set of uPA downstream proteins provides new insight into the function of uPA in HCC cells.
Correction: Improving Men’s Participation in Preventing Mother-to-Child Transmission of HIV as a Maternal, Neonatal, and Child Health Priority in South Africa
Authors: Wessel van den Berg, Kirsty Brittain, Gareth Mercer, Dean Peacock, Kathryn Stinson, Hanna Janson, Vuyiseka Dubula
Journal: PLoS Medicine (2015)
Uses of Cardiac Catheterization in Acquired Heart Disease
Authors: Arthur Selzer, Forrest M. Willett, Donald J. McCaughey, Thomas V. Feichtmeir
Journal: New England Journal of Medicine (1957)

CARDIAC catheterization was introduced in this country in 1941.1 Its potentialities as a revolutionary research tool were immediately apparent, and within a short time it was also applied as an aid in the diagnosis of congenital heart disease. In recent years, cardiac catheterization has been found increasingly useful as an aid in the diagnosis and evaluation of certain acquired cardiac lesions. Its application in these conditions is technically more involved than its diagnostic use in congenital malformations: in simple cases of the latter group, it may suffice to determine the oxygen content of samples withdrawn from a few regions of . . .
JAPAN
Journal: JAMA (1928)

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Gulstonian Lectures on the Uses of Blood-Letting in Disease
Authors: W. O. Markham
Journal: BMJ (1864)

I IIAVFE lingered long on this theory of a change of type in diseases, and have been led on to discuss it freely, not only because I believe it to be an incorrect theory, but chiefly because it is certain that its rejection would remove the greatest obstacle which now interferes with our taking a fair measure of the value of blood-letting at the present time.If it could be satisfactorily shown that the theory was erroneous, then the profession would be bound to re- consider the whole matter, and would, I am satisfied, once again take the lancet in hand and bleed their patients, not certainly as our forefathers did, without rhyme or reason, and under the blinding influence of false theories, but rationally-to the benefit of the sick, and in accordance with the teachings of modern medical knowledge.
439O Tracking spatiotemporal T790M heterogeneity in patients with EGFR-mutant advanced NSCLC after acquired resistance to EGFR TKIs
Authors: Y-C. Zhang, C. Pi, E-E. Ke, Z-H. Chen, J. Su, Z-Y. Dong, C-R. Xu, H-H. Yan, H-Y. Tu, W-Z. Zhong, X-C. Zhang, J-J. Yang, X-N. Yang, Q. Zhou, Y-L. Wu
Journal: Annals of Oncology (2016)
Meat for Millions
Journal: JAMA (1941)

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Medical Students
Journal: JAMA (1964)

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Medicolegal
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Coding Errors in Survey Study
Authors: Steven Nissen, Sreekumar Pillai
Journal: JAMA Cardiology (2018)

Paul S. Chan, MD, MSc; Sarah L. Krein, PhD, RN; Fengming Tang, MS; Theodore J. Iwashyna, MD, PhD; Molly Harrod, MS; Mary Kennedy, BA; Jessica Lehrich, BS; Steven Kronick, MD; Brahmajee K. Nallamothu, MD, MPH; for the American Heart Association’s Get With the Guidelines–Resuscitation Investigators
Reports on Sanitary Engineering in Houses, Hospitals, and Public Institutions
Authors: W. Eassie
Journal: BMJ (1874)

The G'as-&p.Pply.-InEngland, as a rule, we are culpably careless about our gas-supply.A gas company, for instanice, receives notice that the service of such and such a house is ready to be colinected with their main; anId when they have obtained a signed agreement setting forth who is responsible for payment, the meter is connected forthwith, and there is ani end of it.The gas-fitter siay have done many things badly, and not done some things at all; but the gas company seldom, very rarely ever, exercises any jurisdiction.*The gas-fitter next sends in his account, which is paid; and w-hen the smell of escaped gas from some faulty portion of the pipes has become tunbearable, he is sent for to re- medy it, and charges for the rectification.The workman may be thoroughly incompetent, as gas-fitting is not, as it should be, a separate trade.Indeed, the artisan who performed the work may be a black- smith, white-smith, glazier, brazier, plumber, bell-hanger, and gas-fitter, all rolled into one.
THE PSYCHIC FACTOR IN EXOPHTHALMIC GOITER
Journal: JAMA (1921)

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Error in P Value in Abstract and Results
Authors: Jonathan Santoro, Kelli Paulsen
Journal: JAMA Neurology (2020)

Ashkan Shoamanesh, MD; Robert G. Hart, MD; Stuart J. Connolly, MD; Scott E. Kasner, MD; Eric E. Smith, MD; Joan Martí-Fàbregas, MD; Yan Yun Liu, MSc; Shinichiro Uchiyama, MD; Robert Mikulik, MD; Roland Veltkamp, MD; Martin J. O’Donnell, MD; George Ntaios, MD; Keith W. Muir, MD; Thalia S. Field, MD; Gustavo C. Santo, MD; Veronica Olavarria, MD; Hardi Mundl, MD; Helmi Lutsep, MD; Scott D. Berkowitz, MD; Mukul Sharma, MD
Renal Vein Ligation
Authors: Raymond C. Read
Journal: JAMA (1970)

<h3>To the Editor.—</h3> The letter from Drs Jennings and Glucksman (<b>213</b>: 1905, 1970) introduced a case demonstrating that renal vein ligation, unlike thrombosis, was without deleterious effect. They could find no report of this fact. Nevertheless there are a number of references to division of the left renal vein in man. First described by Erlik et al<sup>1</sup>in 1964, they and others<sup>2-4</sup>later have presented a series of cirrhotic individuals in whom the vena caval stump was used for portarenal anastomosis with no detectable harm to the kidney. Three years ago Gonzalez et al<sup>5</sup>reported inThe Journalthat, during removal of a pheochromocytoma, they ligated the left renal vein of their patient without permanent sequelae. About the same time, Neal and Shearburn<sup>6</sup>recommended division of the left renal vein as an adjunct to resection of abdominal aortic aneurysm, having performed this maneuver in 11 patients.
Correction: Risk of epilepsy after febrile convulsions: a national cohort study
Journal: BMJ (1992)

ated with the development of pneumonia.2 3Reiw support the use of acid inhibition since there is no of the notes of patients who died showed no evidence evidence yet that a reduction in endoscopic stigmata is suggesting an excess of pneumonia in patients taking of clinical benefit.omeprazole, although this may have been missed as the study was not specifically designed to detect this.
A Randomized Phase II, Open Label, Study of Daratumumab, Weekly Low-Dose Oral Dexamethasone and Cyclophosphamide with or without Pomalidomide in Patients with Relapsed and Refractory Multiple Myeloma
Authors: Michael Sebag, Nizar Bahlis, Christopher P. Venner, Arleigh McCurdy, C. Tom Kouroukis, Jesse Shustik, Darrell J White, Rami Kotb, Julie Stakiw, Nicole B. Laferriere, Tony Reiman, Fernando Camacho, Julia Dobbin, Molei Fu, Engin Gul, Donna E Reece
Journal: Blood (2019)
Toxicity of Culture Material of Fusarium verticillioides Strain MRC 826 to Nonhuman Primates
Authors: Wentzel C. A. Gelderblom, Jurgen V. Seier, Petra W. Snijman, Dirk J. Van Schalkwyk, Gordon S. Shephard, Walter F. O. Marasas
Journal: Environmental Health Perspectives (2001)
Pediatrics
Authors: C. Becket Mahnke
Journal: JAMA (2005)

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Randomized, Open-Label, Phase III Study of a 28-Day Oral Regimen of Eniluracil Plus Fluorouracil Versus Intravenous Fluorouracil Plus Leucovorin as First-Line Therapy in Patients With Metastatic/Advanced Colorectal Cancer
Authors: Richard L. Schilsky, Jeremey Levin, William H. West, Alfred Wong, Bruce Colwell, Michael P. Thirlwell, Rafat H. Ansari, William N. Bell, Robin L. White, Barbara B. Yates, Paul V. McGuirt, Richard Pazdur
Journal: Journal of Clinical Oncology (2002)

PURPOSE: To compare the efficacy and tolerability of eniluracil (EU)/fluorouracil (5-FU) with that of 5-FU/leucovorin (LV) as first-line therapy for patients with metastatic/advanced colorectal cancer. PATIENTS AND METHODS: This multicenter, randomized, open-label, phase III study (FUMA3008) conducted in the United States and Canada compared the safety and efficacy of EU/5-FU (11.5 mg/m 2 /1.15 mg/m 2 twice daily for 28 days every 35 days) with that of intravenous 5-FU/LV (425 mg/m 2 /20 mg/m 2 once daily for 5 days every 28 days) in patients with previously untreated metastatic colorectal cancer. Overall survival (OS) was the primary end point. RESULTS: A total of 981 patients were randomized and 964 patients received treatment (485 EU/5FU, 479 5FU/LV). Survival for EU/5-FU was not statistically equivalent (but not statistically inferior) to that for 5-FU/LV (hazard ratio, 0.880; 95% confidence interval [CI], 0.75 to 1.03). Median duration of survival was 13.3 months in the EU/5-FU group and 14.5 months in the 5-FU/LV group. Median duration of progression-free survival for EU/5-FU was statistically inferior to that of the control group (20.0 weeks [95% CI, 19.1 to 20.9 weeks] v 22.7 weeks [95% CI, 18.3 to 24.6 weeks]; P = .01). Both treatments were well tolerated. Diarrhea was the most common nonhematologic toxicity in both groups; treatment-related grade 3 or 4 diarrhea occurred in 19% of patients treated with EU/5-FU and 16% of patients receiving 5-FU/LV (P = .354). Grade 3 or 4 granulocytopenia occurred in 5% of EU/5-FU patients and 47% of 5-FU/LV patients. CONCLUSION: Safety profiles of both treatments were acceptable. Although antitumor activity was observed, EU/5-FU did not meet the protocol-specified statistical criteria for equivalence to 5-FU/LV in terms of OS.
Evaluation and Treatment of Primary Hyperparathyroidism
Authors: A. Grey
Journal: JAMA (2005)

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Abstract O.51: Effects of Anti-TNF-alpha Antibody Therapy on IVIG-resistant Patients with Kawasaki Disease
Authors: Hiroshi Masuda, Jun Abe, Shinji Oana, Akira Ishiguro, Nao Tsuchida, Hirokazu Sakai, Shuichi Ito, Hiroshi Ono, Hitoshi Kato
Journal: Circulation (2015)

Background: Kawasaki disease (KD) patients who do not respond to initial intravenous immunoglobulin (IVIG) therapy have a higher risk of developing coronary artery lesions (CALs). Infliximab (IFX) has been reported to be effective in alleviating fever in these patients and has been increasingly used. However, little is known about how IFX suppresses inflammation in KD. We analyzed immunological parameters in KD patients who responded to IFX, as well as those who did not, after the initial IVIG therapy. Methods: Twenty-six KD patients hospitalized and treated with IFX after initial IVIG and aspirin between August 2009 and July 2014 were enrolled in this study. We analyzed electronic medical records of baseline characteristics and laboratory data (WBC, neutrophil, lymphocyte and platelet counts, levels of GOT, GPT, Alb, Na, CRP and D-dimer), and measured plasma levels of cytokines (G-CSF, IL-6, IL-8, IL-10, IL-12p70, IL-17, TNF-α, IFN-γ, sIL-2R, sTNFR1 and sTNFR2) before and after IFX. We defined responders as patients who became afebrile within two days after IFX treatment. Results: The median age of 17 responders (11 males and 6 females) and 9 non-responders (5 males and 4 females) was 31 mo (9-84 mo) and 39 mo (16-64 mo), respectively (p=0.65). The initiation of IFX treatment after the onset of fever was compatible in both the group (day 9 vs day 9 in medians) (p=0.85). The incidence of CALs one month after onset was 0% (0/17) and 22% (2/9), respectively (p=0.11). Observed only in responders, WBC and neutrophil counts, and the levels of CRP, D-dimer, G-CSF, IL-6, sIL-2Rα, TNF-α, sTNFR-1 and sTNFR-2 decreased remarkably after IFX (p&lt;0.01). In non-responders, serum level of Na was significantly lower (p=0.04) before IFX, while WBC (p=0.04) and neutrophil (p=0.01) counts, and the levels of CRP (p=0.02), IL-6 (p=0.01), IL-10 (p=0.03) were higher. After IFX, the level of Alb (p=0.02) was lower. Conclusions: After IFX, the level of TNF-α, together with many pro- and anti-inflammatory mediators, decreased in responders but not in non-responders. In particular, suppression of IL-6 and IL-10 was insufficient in non-responders, suggesting that inflammation mechanisms other than the TNF-α axis would be important in KD patients who are unresponsive to IFX.
Booknotes
Journal: JAMA (1984)

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