tbuckley/cabot-search huggingface dataset:
VENTILATION/PERFUSION LUNG IMAGING IN PULMONARY EMBOLISM: ANALYSIS WITH CONSIDERATIONS OF SIZE, NUMBER OF SEGMENTS AND CHEST X-RAY.
Authors: Lalitha Ramanna, Alan D. Waxman, Michael B. Brachman, Dhana Kaushik, Peter Julien, Daniel S. Berman, Doina Tanasescu
Journal: Clinical Nuclear Medicine (1983)

Ramanna, Lalitha; Waxman, Alan D.; Brachman, Michael B.; Kaushik, Dhana; Julien, Peter; Berman, Daniel S.; Tanasescu, Doina Author Information
The Putative Tumor Suppressor microRNA-101 Modulates the Cancer Epigenome by Repressing the Polycomb Group Protein EZH2
Authors: Jeffrey M. Friedman, Gangning Liang, Chun-Chi Liu, Erika M. Wolff, Yvonne C. Tsai, Wei Ye, Xianghong Zhou, Peter A. Jones
Journal: Cancer Research (2009)

The Polycomb Repressive Complex 2 (PRC2) mediates epigenetic gene silencing by trimethylating histone H3 lysine 27 (H3K27me3) and is known to aberrantly silence tumor suppressor genes in cancer. EZH2, the catalytic subunit of PRC2, enhances tumorigenesis and is commonly overexpressed in several types of cancer. Our microRNA profiling of bladder transitional cell carcinoma (TCC) patient samples revealed that microRNA-101 (miR-101) is down-regulated in TCC, and we showed that miR-101 inhibits cell proliferation and colony formation in TCC cell lines. Furthermore, our results confirm that miR-101 directly represses EZH2 and stable EZH2 knockdowns in TCC cell lines create a similar growth suppressive phenotype. This suggests that abnormal down-regulation of miR-101 could lead to the overexpression of EZH2 frequently seen in cancer. We conclude that miR-101 may be a potent tumor suppressor by altering global chromatin structure through repression of EZH2.
Abstract 1809: Survival And Neurologic Recovery In Patients With ST-Elevation Myocardial Infarction Resuscitated From Cardiac Arrest
Authors: Vivek Reddy, Vinay R Hosmane, Nowwar Mustafa, Charles Reese, Angela DiSabatino, Paul Kolm, William S Weintraub, Ehsanur Rahman
Journal: Circulation (2007)

Methods: We examined records of 2290 consecutive patients at our institution suspected of having ST-Elevation myocardial infarction (STEMI) from 1/1/02 to 12/31/06. Our study group comprised 99 STEMI patients resuscitated from cardiac arrest who were taken for emergent catheterization. Percutaneous coronary intervention was performed in 66, bypass surgery in 12, and 21 have neither. Endpoints were in-hospital death and neurologic recovery. Logistic regression was used for analysis. Results: Overall 64 (65%) survived and 35 (35%) died. Full neurologic recovery was seen in 59 (92%) of the survivors. On evaluation before catheterization: 25 were alert , 14 were minimally responsive to pain and stimuli, 60 were unresponsive . Patients in the latter two groups were intubated. In the unresponsive group (n=60), 27 survived (45%) and 33 died. Full neurologic recovery was seen in 23/27 survivors (85%). Predictors of death and neurologic recovery are shown in Table 1 and Table 2 . Table 1: Logistic Regression for Death For the Entire Group (c index = 0.894), N= 99 Table 2: Logistic Regression for Death for the Unresponsive Group (c index = 0.898), N=60
Significance of the Blood Beryllium Lymphocyte Proliferation Test
Authors: Lee S. Newman
Journal: Environmental Health Perspectives (1996)

The blood beryllium lymphocyte proliferation test (BeLPT) is an in vitro measure of the beryllium antigen-specific cell-mediated immune response.This response to beryllium is now understood to play a central role in the immunopathogenesis of chronic beryllium disease (CBD).Although there remain some unresolved methodologic issues with testing, the blood BeLPT has already undergone sufficient development and field assessment to lead to a number of important conclusions: a) The BeLPT identifies beryllium sensitization and CBD earlier and better than any other clinical test presently available.b) The CBD cases identified with the blood test are clinically significant.c) A subset of the people identified by the BeLPT who do not yet have clinical disease will progress and require treatment with corticosteroids for impairing illness.d) The BeLPT can be used to improve clinical diagnostic accuracy and to correct mistaken diagnoses.e) The blood test can be used in screening large numbers of exposed workers because it is sensitive and specific and has high positive and negative predictive value for CBD.f) In every workforce studied to date, the BeLPT has identified beryllium sensitization and CBD that had been missed by conventional screening efforts.g) Worker populations that have been characterized using the BeLPT can help to elucidate the role of exposure genetics and dysregulated inflammation in the genesis of occupational lung disease.
Die Experimentelle Bakteriologie und die Infektionskrankheiten mit besonderer Berücksichtigung der Imunitätslehre.
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Health Care
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Resectable Rectal Cancers
Authors: Jean Papillon
Journal: JAMA (1975)

IT IS GENERALLY considered that rectal carcinoma is only slightly radiosensitive, and that radiation therapy has no place in its curative treatment. This opinion is not true in the case of early rectal cancers that can be treated by<i>endocavitary irradiation</i>. Rectal adenocarcinoma proves to be very radiosensitive with this method. The response of the tumor is favorable, even surprising; the chances of local control are good, as long as the indications are strictly respected. Endocavitary irradiation of rectal cancers consists of two techniques, contact x-ray therapy and interstitial curietherapy. <h3>Contact X-ray Therapy</h3> The characteristics of the machine used for contact x-ray therapy are a low voltage (50 kv), short focal distance (4 cm), high output (1,500 roentgen/min in air), a narrow tube (able to be introduced in a special rectoscope 3 cm in diameter) and substantial absorption of the radiation in the first 2 cm. The tube is very
Herrick's 1910 case report of sickle cell anemia. The rest of the story
Authors: T. L. Savitt
Journal: JAMA (1989)

James B. Herrick's 1910 article presenting the case of an anemic West Indian student with peculiar-shaped red blood cells was the first description of sickle cell anemia in Western medical literature. However, he told only part of the story. Records in Chicago, Washington, DC, and Grenada, West Indies, reveal more information about the events surrounding Herrick's discovery and help put them in historical perspective. Herrick's intern, Ernest E. Irons, abreast of the latest developments in medicine, actually performed the blood work and alerted Herrick about the odd-looking cells. Changing patterns in American race relations allowed the patient, Walter Clement Noel, to study dentistry in Chicago. He continued to receive care from Irons for 2 1/2 years, then returned to Grenada to practice dentistry. Noel died nine years after his return to Grenada, at age 32.
Obstructive Sleep Apnea Increases the Risk of Sudden Cardiac Death: A Longitudinal Study of 10,701 Adults
Authors: Apoor Gami
Journal: Circulation (2008)

Abstract 505 Apoor S Gami, Eric J Olson, Win K Shen, R Scott Wright, Karla V Ballman, David O Hodge, Regina M Herges, Daniel E Howard, Virend K Somers, Mayo Clinic, Rochester, MN Apoor Gami, 2008 Finalist and Presenting Author
Leads from the MMWR. Pertussis--United States, 1982 and 1983
Journal: JAMA (1984)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Proprietaries, Pianos and Probity
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE CAUSATION OF DEATH DURING THE ADMINISTRATION OF CHLOROFORM
Authors: E. H. Embley
Journal: BMJ (1902)

<b>32</b> <h3><b>Objectives</b></h3> Studies of dopamine (DA) release to psychostimulant challenge have consistently shown blunting in the striatum across multiple drugs of abuse, but results have been equivocal for cannabis. We examined amphetamine (AMPH) induced DA release in striatal and extra-striatal regions with PET to study cannabis dependent (CD) individuals who used cannabis heavily and no other substances, including nicotine. We used the D<sub>3</sub>R-preferring agonist tracer [<sup>11</sup>C]PHNO. <h3><b>Methods</b></h3> 11 CD, following acute detoxification for 3 days, and 12 healthy controls (HC) underwent 2 PET scans on one day with [<sup>11</sup>C]PHNO, at baseline and 3 hr following PO AMPH, 0.5 mg/kg. Scans were 2 hr and acquired on an mCT scanner. Each subject9s PET data were registered to a high-resolution T1-weighted MRI image on which ROIs were drawn and transferred to the PET. Data were analyzed using SRTM with cerebellum as reference tissue. ROIs included associative striatum (AST), sensory motor striatum (SMST), limbic striatum (LST), globus pallidus (GP), thalamus (THA) and midbrain (MID). Outcome measures were BP<sub>ND</sub> and the % change in BP<sub>ND</sub> following AMPH (ΔBP<sub>ND</sub>). <h3><b>Results</b></h3> Baseline BP<sub>ND</sub> did not differ between groups. Robust decrease of BP<sub>ND</sub> was observed in all subjects following AMPH, but the extent of decrease was less in CD than in HC in AST (15% vs 21%, p=.008), SMST (25% vs 32% p=.005), and GP (13% vs. 23%, p=.01). Effect sizes for these differences were 1.4, 1.3 and 1.2, respectively. ΔBP<sub>ND</sub> was decreased but not significantly different between groups in LST (26% vs 32%, p=.13 ), MID (28% vs 34%, p=.43), and THA (25% vs %27, p=.85). <h3><b>Conclusions</b></h3> Blunted dopamine transmission in the associative and sensory motor subregions of the striatum is observed in CD with heavy use and no other substance dependencies. This pattern is different from that observed with other substances where the predominant effect is in LST. Future studies should investigate the significance of this pattern for the behavioral effects of cannabis, especially in terms of increasing the vulnerability to psychosis. <h3><b>Research Support</b></h3> R01DA022455
CONSIDER HER WAYS AND BE WISE
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medico=Chirurgical Transactions.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Update: Staphylococcus aureus With Reduced Susceptibility to Vancomycin—United States, 1997
Journal: JAMA (1997)

Staphylococcus aureus is one of the most common causes of both hospital- and community-acquired infection worldwide. Since the emergence of methicillin-resistant S. aureus (MRSA) in the 1980s in the United States, vancomycin has been the antimicrobial agent of choice for serious MRSA infections. S. aureus with reduced susceptibility to vancomycin (minimum inhibitory concentration [MIC]=8 micro/mL) was first reported to have caused infection in a patient in Japan in May 1996. In August 1997, the first S. aureus isolate intermediately resistant to vancomycin (VISA; MIC=8 micro/mL) in the United States was reported in Michigan. This report updates the ongoing investigation in Michigan and describes preliminary findings of the ongoing investigation of a second case of VISA infection in a patient in New Jersey.
How justifiable is public support of sexually transmitted disease clinical services?
Authors: W. Cates
Journal: JAMA (1986)

Recent concern about increasing budget deficits has led some policymakers, health planners, and clinicians to reconsider the issue of public support of sexually transmitted disease (STD) clinical services. Moreover, the expanded spectrum of sexually transmitted organisms—especially the specter of human T-cell lymphotropic virus type III—has placed heightened demands on already-limited resources. Arguments to limit public resources have generally contained five overlapping themes<sup>1</sup>: Disincentive to Prevention.—"Free" clinics encourage disease-prone behavior (such as nonuse of condoms) by removing the cost incentive. Promotion of Irresponsible Behavior.—"Free" clinics "foster" sexual irresponsibility; it is unfair to expect taxpayers to underwrite the sequelae of "irresponsible sex." Better Use of Funds.—"Free" STD clinics compete for limited public health resources, which would be better applied to more cost-effective preventive interventions. No Public Health Threat.—Sexually transmitted diseases pose no general threat to the public at large; the "truly innocent victims" are few in number and
Effect of Low Molecular-Weight Dextran on Red Blood Cell Charge During Clinical Extracorporeal Circulation
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Government Services
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fifth Annual Symposium of the Cancer Research Center at the University of North Carolina School of Medicine at Chapel Hill
Journal: JNCI Journal of the National Cancer Institute (1981)

Journal Article Fifth Annual Symposium of the Cancer Research Center at the University of North Carolina School of Medicine at Chapel Hill Get access JNCI: Journal of the National Cancer Institute, Volume 66, Issue 1, January 1981, Page 213, https://doi.org/10.1093/jnci/66.1.213-b Published: 01 January 1981