tbuckley/cabot-search huggingface dataset:
GCT-28. RECURRENCE PATTERN AND SURVIVAL FOR RELAPSED INTRACRANIAL NON-GERMINOMATOUS GERM CELL TUMORS: A SINGLE-INSTITUTION EXPERIENCE
Authors: Lei Wen, Zhaoming Zhou, Qingjun Hu, Juan Li, Mingyao Lai, Cheng Zhou, Changguo Shan, Junjie Zhen, Weiping Hong, Xing Zhang, Yangqiong Zhang, Rishun Luo, Lichao Wang, Linbo Cai
Journal: Neuro-Oncology (2020)

Abstract PURPOSE Intracranial non-germinomatous germ cell tumors (NGGCTs) have lower overall survival than germinoma because relatively higher recurrence usually occurs after first line therapy. METHODS Between January 2003 and December 2018, 111 consecutive patients diagnosed with NGGCTs reviewed. Those who progressed after first line therapy were included in this study. Data of first line treatment, salvage treatment, clinicopathological features and survival were collected and analyzed. RESULTS Totally, thirty patients (30/111, 27.0%) relapsed in our cohort, including 19 patients with accurate relapse information detail, and 11 patients who died of disease progression during follow up but without exact time and site of relapse. The median OS from diagnosis of the disease was 49.2 months (95% CI: 14.1 to 84.3 months) and 3-year OS was 54.3%. Patients who received both CSI and chemotherapy relapsed less than those who received reduced volume of radiotherapy or only CSI or only chemotherapy (22.5% vs. 45.5%, p=0.034). Of 19 patients who had detail information of recurrence time and site, the median time from diagnosis of disease to relapse was 9.5 months (2.2 to 72.1 months). Regarding to recurrence site, most patients relapsed in primary site (10/19, 52.6%) or distant intracranial (6/19, 31.6%). The recurrence site of other 3 patients were spinal (n=1), ventricular (n=1) and peritoneal (n=1). CONCLUSION Protracted follow-up is recommended because late recurrence is not uncommon. Primary tumor site and distant intracranial are the most prevalent relapsed location. Patients who relapsed could benefited from both CSI and salvage chemotherapy.
Seventh European Symposium on Hormones and Cell Regulation
Journal: JNCI Journal of the National Cancer Institute (1982)

Journal Article Seventh European Symposium on Hormones and Cell Regulation Get access JNCI: Journal of the National Cancer Institute, Volume 68, Issue 5, May 1982, Page 881, https://doi.org/10.1093/jnci/68.5.881-a Published: 01 May 1982
Maternal Hypercholesterolemia During Pregnancy Promotes Early Atherogenesis in LDL Receptor-Deficient Mice and Alters Aortic Gene Expression Determined by Microarray
Authors: Claudio Napoli, Filomena de Nigris, John S. Welch, Federico B. Calara, Robert O. Stuart, Christopher K. Glass, Wulf Palinski
Journal: Circulation (2002)

Background — Maternal hypercholesterolemia during pregnancy is associated with markedly enhanced fatty streak formation in human fetal aortas and accelerated progression of atherosclerosis in normocholesterolemic children. Methods and Results — To establish the causal role of maternal hypercholesterolemia in a genetically homogeneous murine model and to test the hypothesis that pathogenic events during fetal development result in persistent changes in arterial gene expression, female LDL receptor-deficient (LDLR −/− ) mice were fed regular chow or high-fat diets supplemented with 0.075% or 1.25% cholesterol during pregnancy. Lesion sizes were determined in the aortic origin of their chow-fed offspring at 3 months. Maternal hypercholesterolemia more than doubled lesion sizes in male offspring ( P &lt;0.0001 for the 0.0075% cholesterol group). Microarray analysis of the expression of 11 000 murine genes in the nonatherosclerotic descending aorta by Affymetrix gene chips suggested that 139 genes were significantly regulated in offspring of hypercholesterolemic mothers. A subset of 12 of the upregulated transcripts was subjected to secondary analysis by semiquantitative PCR of pooled RNA and 4 genes were found to be upregulated &gt;1.7-fold. Quantitative PCR for one of these genes using RNA from individual mice yielded similar results. Comparative immunostaining for several of the above genes also indicated increased protein content in offspring of hypercholesterolemic mothers. Conclusions — These findings establish an atherogenic effect of maternal hypercholesterolemia in genetically uniform mice and indicate that changes in aortic gene expression persist long after fetal exposure to hypercholesterolemia. In addition to elucidating pathogenic mechanisms initiated during fetal development, this approach may identify genes in morphologically normal arteries that influence the susceptibility to classical risk factors of atherosclerosis.
"METALLOPTYSIS". E.M. HADLEY AND P.J. REES. EUR RESPIR J 2006; 27: 867-868.
Journal: European Respiratory Journal (2006)

Unfortunately, the legend of figure 1 was printed incorrectly.The figure legend should read as follows: Photographs displaying some of the staples the patient expelled.a) The third staple expelled.b) The expelled four linked, closed staples.Scale bars50.2mm (a) and 500 mm (b).
EPID-11. OCCURRENCE OF SYSTEMIC CANCER IN PATIENTS WITH GLIOBLASTOMA: POPULATION CHARACTERIZATION AND COMPLICATIONS
Authors: Erika Horta, Tobias Walbert, James Snyder
Journal: Neuro-Oncology (2019)

Abstract It is unclear how the diagnosis of a second cancer influences the treatment and complications of patients with glioblastoma (GBM). A chart review of adults with primary or secondary GBM and another systemic cancer seen in the last five years was performed. Demographic data, thromboembolic events, cytopenia and deviations from the standardized GBM treatment protocol (EBRT with 60 Gy plus concurrent temozolomide followed by adjuvant temozolomide) were analyzed. Exclusion criteria was the diagnosis of genetic syndromes that predispose to tumorigenesis. A total of 56 GBM patients with 61 systemic cancers were identified. The most common systemic cancers were breast and prostate each representing 27 %. Men were 55% of patients (p=0.3) but older (69+11 years, p=0.003) than when compared to CBTRUS data. Systemic cancer was diagnosed before GBM in 82% of the cases. Age at the diagnosis of systemic cancer was 64 +11 years. Patients with systemic cancer diagnosed prior to GBM, had shorter survival (1.15+1.08 years versus 4.4+ 3.4 years, p &lt; 0.001), but survival was not shorter than expected when compared to historical survival of GBM. Thromboembolism was seen in 27% of patients, only once it was seen before the diagnosis of GBM. Although all patients with hematological malignancies had low platelets, thrombocytopenia was not associated to prior chemotherapy. Deviation of GBM treatment was seen in 15% of the cases, a delay in the systemic cancer once. This is the largest documented series of patients with GBM and systemic cancer. We conclude that although this population is older than expected, thromboembolism rates and survival are similar to the literature for patients with GBM. In the light of all those considerations, patients with GBM and the diagnosis of a systemic cancer should be treated according to guideline.
Sputum periostin in patients with different severe asthma phenotypes
Authors: H. Kimura, M. Suzuki, S. Konno, M. Nishimura, I. Bobolea, P. Barranco, V. del Pozo, D. Romero, V. Sanz, V. López‐Carrasco, J. Canabal, C. Villasante, S. Quirce
Journal: Allergy (2015)
THE SPECIALIST BEFORE A GENERAL MEDICAL SOCIETY.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Author’s reply: The Russian gonococcal antimicrobial susceptibility programme (RU-GASP)--national resistance prevalence in 2007 and 2008, and trends during 2005-2008
Authors: M Unemo, M Domeika
Journal: Eurosurveillance (2010)

Preview this article: Author’s reply: The Russian gonococcal antimicrobial susceptibility programme (RU-GASP)--national resistance prevalence in 2007 and 2008, and trends during 2005-2008, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/15/19/art19569-en-1.gif
Omega-3 Polyunsaturated Essential Fatty Acid Status as a Predictor of Future Suicide Risk
Authors: M. Elizabeth Sublette
Journal: American Journal of Psychiatry (2006)

Objective: Low levels of docosahexaenoic acid, a polyunsaturated fatty acid, and elevated ratios of omega-6/omega-3 fatty acids are associated with major depression and, possibly, suicidal behavior. Predicting risk of future suicidal behaviors by essential fatty acid status merits examination. Method: Plasma polyunsaturated fatty acid levels in phospholipids were measured in 33 medication-free depressed subjects monitored for suicide attempt over a 2-year period. Survival analysis examined the association of plasma polyunsaturated fatty acid status and pathological outcome. Results: Seven subjects attempted suicide on follow-up. A lower docosahexaenoic acid percentage of total plasma polyunsaturated fatty acids and a higher omega-6/omega-3 ratio predicted suicide attempt. Conclusions: A low docosahexaenoic acid percentage and low omega-3 proportions of lipid profile predicted risk of suicidal behavior among depressed patients over the 2-year period. If confirmed, this finding would have implications for the neurobiology of suicide and reduction of suicide risk.
Atrophic Gastritis
Authors: Lee Sataline
Journal: JAMA (1985)

<h3>To the Editor.—</h3> In the Dec 7, 1984, issue ofThe Journal, Dr Dworken<sup>1</sup>discussed the management of a patient with abdominal pain and intermittent diarrhea presumably caused by atrophic gastritis. Because of the increased number of elderly patients who now undergo endoscopy, atrophic gastritis is not an uncommon histologic finding in the gastric biopsy specimens. However, before starting a regimen of antibiotics for presumed bacterial overgrowth for such patients, I would strongly recommend that lactose intolerance be excluded either by dietary elimination or, preferably, a lactose tolerance test using the patient's symptoms (or lack thereof) as the end point. Because intestinal transit times in the elderly may be slower, symptoms may not develop until several hours after ingestion of the lactose.
PRESBYOPIA.
Authors: E. J. GARDINER
Journal: JAMA (1904)

Not long ago a number of medical men were gathered after luncheon at one of the down-town clubs. They were all about the same age—somewhere between 45 and 50⁁and were amusing themselves by gently twitting one of the number who was wearing his first glasses for presbyopia. This twitting led to a discussion, brought about by my defense of the wisdom manifested by the victim in wearing glasses for reading. A test was made<i>in situ</i>with small print, which revealed that every man present was presbyopic. This was not surprising, but the interesting feature to me was, first the aversion they all had to admit the presence of presbyopia, and then the reasons advanced for not using glasses for its correction. No one, of course, wishes to admit a failure of the faculties. That a perfectly normal change, brought about by a maturing process in the eye,
The Toxemias of Pregnancy
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Interarticular dislocation of the patella
Authors: C. N. Stover
Journal: JAMA (1967)

DISLOCATION of the patella into the interarticular space is apparently rare, but as so often the case, optimum treatment depends upon one's awareness of this injury. Brady and Russell,<sup>1</sup>in a recent review of the literature, were able to collect 25 cases. To this group they added one of their own, and concluded that closed manipulation was rarely, if ever, successful. They advised prompt open reduction. The following case report supports this contention. <h3>Report of a Case</h3> A 12-year-old white boy was struck by a car while riding his bicycle on the evening of Aug 30, 1963. He sustained injury to his left shoulder and his right knee. He was taken to a nearby hospital where roentgenographic examination revealed an undisplaced fracture of the surgical neck of the right humerus and an interarticular dislocation of the right knee (Figure). These x-ray films showed the patella rotated 90° about its
Factor IX Deficiency In Liver Disease
Authors: Stephen Lee
Journal: JAMA (1972)

<h3>To the Editor.—</h3> We agree with the suggestion of Donaldson et al<sup>1</sup>that intrinsic as well as extrinsic coagulation factors should be tested for when screening patients with liver disease for surgery or biopsy. We have recently had three incidents where low levels of factor IX would have been missed in patients with liver disease if only the Quick prothrombin time had been taken. The first case concerned a 55-year-old woman with lymphosarcoma and chronic, active hepatitis. Results of liver-function tests included the following values: bilirubin, 4.8 mg/100 ml; serum glutamic oxaloacetic transaminase (SGOT), 254 units/ml; serum glutamic pyruvic transaminase (SGPT), 86 units/ml; and alkaline phosphatase, 44.2 King-Armstrong units/ ml. There was no familial or past history of abnormal bleeding. Results of coagulation studies included normal Quick prothrombin times on three occasions: 100% (12 seconds), 100% (12.4 seconds), and 88% (14.2 seconds); abnormal partial thromboplastin time, 65 seconds (normal,
Survival after secondary liver resection in metastatic colorectal cancer: A comparative analysis of the LICC trial with historical controls (CELIM, FIRE-3).
Authors: Markus Hermann Moehler, Gunnar Folprecht, Volker Heinemann, Julian Holch, Annett Maderer, Stefan Kasper, Susanna Hegewisch-Becker, Jan Schroeder, Friedrich Overkamp, Frank Kullmann, Wolf Otto Bechstein, Matthias Voehringer, Robert Oellinger, Florian Lordick, Michael Geissler, Armin Schulz-Abelius, Bernhard Linz, Helga Bernhard, Irene Schmidtmann, Carl Christoph Schimanski
Journal: Journal of Clinical Oncology (2019)

e15025 Background: Metastatic colorectal cancer (mCRC) patients (pts) with liver-limited disease (LLD) have a chance of long-term overall survival (OS) and potential cure after complete hepatic metastasectomy. The appropriate postoperative treatment strategy is still controversial. L-BLP25 as antigen-specific cancer vaccine targeting mucin 1 (MUC1) was recently evaluated as adjuvant therapy in mCRC pts after R0/R1 LLD resection (LICC trial, NCT01462513). Here we compared the LICC surveillance program and efficacy results for secondarily resected LLD pts versus historical controls, i.e. the CELIM trial (Folprecht et al, Ann Oncol 2014) of potentially resectable LLD mCRC pts and a FIRE-3-LLD subgroup (Holch et al, Int J Cancer 2018). Methods: LICC, CELIM and FIRE-3-LLD subgroup pts with stage IV mCRC limited to liver metastases who underwent hepatic resection (R0 or R1) were compared regarding pts characteristics, surveillance and efficacy outcome. LICC pts received adjuvant L-BLP25 or placebo after secondary LLD resection as 8 weekly doses, followed by 6 week maintenance intervals and tight surveillance until recurrence or a maximum of 2 years. Results: In LICC, 41 /121 pts (33.9%) were secondarily resected, and R0 resection was achieved in 31 pts (75.6%). In CELIM, 36/106 pts (34%) with primary unresectable LLD were secondarily R0 resected. In FIRE-3-LLD, secondary resection was feasible for 29/133 pts (21.8%). After R0 resection, median recurrence free survival (mRFS) was 8.9 months in LICC, 9.9 months in CELIM and 11.5/ 12.4 months in FIRE-3-LLD in either treatment arm. In the LICC trial, median overall survival (mOS) in secondarily resected pts was 65.1 months, with 38.3 months for the R1 and is not yet reached for the R0 subgroup. In CELIM, mOS was 53.9 months for R0 resected pts. In FIRE-3-LLD, after secondary resection mOS was 56.2 months. Median age was about 5 years less in LICC. Further details will be presented. Conclusions: Secondary resected pts of LICC, CELIM and FIRE-3 showed impressive median OS with better OS for LICC and a younger patient cohort. The established tight LICC surveillance program after surgery might have had a positive impact on survival. Clinical trial information: LICC: NCT01462513; FIRE-3: NCT00433927; CELIM: NCT00153998.
E coli Otitis Media
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Renal failure obfuscates the diagnosis of Cushing's disease
Authors: N. A. Sharp
Journal: JAMA (1986)

THE DIAGNOSIS of Cushing's syndrome can be challenging in the patient with chronic renal failure (RF). Spurious overestimation of plasma cortisol,<sup>1</sup>abnormal cortisol binding,<sup>2,3</sup>poor gastrointestinal tract absorption of dexamethasone,<sup>4</sup>and abnormal response to dexamethasone<sup>5</sup>have all been reported to occur in this setting. The hypophyseal-pituitary-adrenal axis appears to be altered in RF, even in patients who lack overt features of Cushing's syndrome, although diurnal variation of plasma cortisol is usually preserved.<sup>5</sup>While much attention has been focused on the laboratory abnormalities in RF patients, little has been published about the occasional RF patient with clinical manifestations of hypercortisolism. The usual diagnostic criteria, standardized for patients with normal renal function, may not be adequate to make the diagnosis. <h3>Report of a Case</h3> A 43-year-old man had a history of type II diabetes mellitus of eight years' duration, hypertension, congestive heart failure, hypertriglyceridemia, and chronic RF
Unusual filling defects in the stomach
Authors: J. J. Pollard
Journal: JAMA (1966)

Dr. Champlain Charest: A 50-year-old man was admitted to the Massachusetts General Hospital for the first time because of abnormal findings on serial x-ray films of the upper-gastrointestinal tract. He was in excellent health until three years before, when he first noted dysphagia. Soon afterward he had occasional fleeting, burning pains in the epigastrium, but the symptoms did not progress and the dysphagia was inconstant. His appetite remained excellent, and, although he had lost 23 lb (10.4 kg) over the previous three years, he regained 12 lb (5.5 kg) in two months after giving up smoking. He had no anemia, hematemesis, melena, vomiting, diarrhea, jaundice, pruritus, or weakness. An x-ray examination of the upper gastrointestinal tract done during hospitalization elsewhere one year ago, was said to show "shrinkage of the esophagus and a spot in the stomach." He was advised to return in two months but failed to do so.
Certified Pink
Authors: Elliott B. Oppenheim
Journal: JAMA (1982)

The mailman became a hated figure to the physician on probation because he brought the certified mail with the familiar pink slip. "CERTIFIED" was written at least three times in red ink on each piece. As the doctor signed each succeeding pink slip, acknowledging receipt of these documents, he also acknowledged his crime and writhed in pain. When his guilty plea appeared in the newspaper, two hospitals immediately terminated his privileges. Certified letters started arriving shortly thereafter. When his license was revoked, certified mail announced the news. When the local medical society struck him from membership and two other hospitals removed him from the staff, more certified letters arrived. His specialty organization hurled the next darts as his colleagues forced his resignation from the local, state, and national chapters. The Drug Enforcement Administration next revoked his controlled substances certificate; another certified letter was on his doorstep. Two more states revoked
Toxic shock syndrome, Staphylococcus aureus, and influenza
Authors: J. K. Todd
Journal: JAMA (1987)

<h3>In Reply.—</h3> Byerly et al share my concern that the formula recommended by the American Heart Association for preparation of cardiac infusion drugs is problematic. The dosage range for isoproterenol, epinephrine, and norepinephrine is from 0.1 μg/kg/min to 1 μg/kg/min. Following the formula set forth by the AHA,<sup>1(p2967)</sup>0.6 times the body weight (in kilograms) equals the milligrams of drug added to the diluent to make 100 mL, to be infused at 1 mL/h. This amount delivers 0.1 μ/kg/min. It is inconceivable, however, that a drip rate of 1 mL/h will ever deliver any drug to the arrested or resuscitated patient, let alone visibly drip out of the intravenous tubing! Byerly et al are also correct in pointing out that the number of ampules needed to supply the dose of isoproterenol, epinephrine, or norepinephrine calculated using the AHA formulawould be unavailable in most settings. Byerly et al