tbuckley/cabot-search huggingface dataset:
Abstract P067: HDL Particles, Immune Activation, Inflammatory and Coagulation Markers in Relation to CVD and All-Cause Mortality Among Adults Aged 80+
Authors: Rachel H Mackey, Timothy M Hughes, Russell P Tracy, Anne B Newman, Yuefang Chang, Oscar L Lopez, Lewis H Kuller
Journal: Circulation (2013)

HDL particles, particularly small HDL particles, may be more functional (e.g. anti-inflammatory) than large HDL particles which carry more cholesterol, but levels are little affected by recent HDL-raising therapies that substantially raised HDL-C without decreasing CHD. Furthermore, lower levels of total and small HDL particles predict CHD and CVD, but have not been evaluated among elderly adults, for whom lipids are generally not positively related to CVD. Therefore, we hypothesized that among adults aged 80+, incident CVD and all-cause CVD mortality would be related to lower levels of total and small HDL particles in addition to higher levels of coagulation, inflammation and immune response biomarkers. Participants (n=162) without dementia at baseline (2001-2002) were followed through 2011 for incident CVD and total mortality. Concentrations of HDL particles (HDL-P) were measured by NMR spectroscopy (LipoScience, Inc), D-dimer, IL-6, sCD-14, and sIL-2r were measured using ELISA (R&amp;D Systems), and soluble receptors sIL6r, and sTNFr1/r2 were measured by Multiplex Panel (Millipore) on stored baseline plasma. Among adults with mean age=83.5 years at baseline, both CVD and total mortality over 8 years follow-up (mean= 5.2 years) were associated with lower baseline levels of total and small HDL-P (but not HDL-C, large HDL-P or larger mean HDL particle size), and higher levels of IL-6, sTNFr1 and sTNFr2 (Table). Total mortality was also associated with higher levels of D-dimer and sIL2r. In Cox models adjusted for age, sex and lipid-lowering medication, lower small HDL-P remained inversely associated with total and CVD mortality, with HR (95%CI) for Q1 vs. Q4 = 3.35(1.30, 8.62) and 5.39 (1.15, 25.34) respectively, and higher IL-6 remained associated with CVD mortality HR(95% CI) for Q4 vs. Q1= 5.22 (1.10, 24.75). Among adults aged 80+, higher IL-6 and lower total and small HDL-P levels were associated with incident CVD and total mortality over 8 years, suggesting an important anti-inflammatory role for HDL particles in late life.
Adoptive Immunotherapy with Autologous CD25-Depleted and CD3/CD28-Costimulated T-Cells (ACTC) Enhances Numeric and Functional Lymphocyte Recovery after Cyclophosphamide - Fludarabine Chemotherapy in Patients with Low-Grade Follicular Lymphoma.
Authors: Charalambos Andreadis, Bruce L. Levine, Julio Cotte, Zhaohui Zheng, Rebecca Mair, Andrea Cannon, Jason Harrow, Marcy Traum, Elise A. Chong, Lisa H. Downs, Dan T. Vogl, Jakub Svoboda, Carl H. June, Stephen J. Schuster
Journal: Blood (2005)
UNITED STATES COURTS VS. POST OFFICE AUTHORITIES ON ABORTIFACIENT NOSTRUMS.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
'One for the road' can lead to loss of license for Minnesota drivers
Authors: P. Gunby
Journal: JAMA (1984)

A major problem associated with abuse of alcohol, of course, is the intoxicated operator of a vehicle in traffic. Now, the National Highway Traffic Safety Administration in Washington, DC, reports that suspension of operators' licenses by direct administrative action, rather than prolonged court procedures, "is a prompt, effective way to remove driving-while-intoxicated offenders from the road." The agency cites the state of Minnesota, where a law provides for a 90-day license revocation that can be served directly by the investigating police officer to any driver whose breath test indicates a blood alcohol concentration greater than 0.10 mg/dL. If the driver refuses to let authorities test his or her breath, the license can be suspended for 180 days. (The driver has the right to request a hearing on such suspensions.) The federal agency says Minnesota's law originally was passed in 1976, then strengthened two years ago. Diane K. Steed, administrator of
Abstract 17288: Risk Prediction of 10-Year Cardiovascular Mortality Using Automated Electrocardiographic Analysis in the National Health and Nutrition Examination Survey
Authors: Amit J Shah, Cecile Janssens, Suman Kundu, Emir Veledar, Peter Wilson, Viola Vaccarino, Elsayed Z Soliman
Journal: Circulation (2014)

Introduction: Several individual ECG parameters are predictive of cardiovascular disease (CVD) mortality, and when combined in a score, may improve risk prediction. Hypothesis: We hypothesized that an ECG risk score (based on automated measures available on many modern ECG machines) can effectively predict CVD mortality, and augment risk classification when added to traditional risk factors (TRF). Methods: We examined 6786 individuals aged 40-79 years without known CVD in NHANES III (1988-1994) followed 10 years for CVD mortality. Six pre-specified ECG variables (“ECG model”), were evaluated including P, R, T axes, QT interval, QRS width, and heart rate. Three risk scores were developed for variables containing: 1) TRF only, 2) ECG factors (including age, sex, and race), and 3) TRF+ECG combined. Validation was performed using a cohort aged 40-74 years from NHANES I (n=3773), enrolled in 1971-1974. Age stratification was performed with cutoff of 65 years because of increased competing risks in older individuals. Results: During 10 years of follow up, 384 CVD deaths occurred. Frontal QRS-T angle, T-axis, wide QRS interval (cutoff 120 ms), heart rate-corrected QT interval, and heart rate were found to be significant predictors (p&lt;0.05) of CVD death. As per the table, the ECG score had similar performance compared to the TRF score for the subgroup &lt; 65 years of age in the derivation and validation cohorts. The score with combined ECG + TRF had the best performance for those aged &lt; 65 years, and resulted in a net reclassification index of 9% in the validation cohort using cutoffs of 7.5% and 20% for low, intermediate, and high risk categories. In those aged ≥ 65 years, the combined score showed improvement vs. the TRF score in the derivation, but not validation cohort. Conclusion: A risk score based on routinely reported automated ECG variables and TRF predicts risk of 10-year CVD death better than TRF alone in a cohort age &lt; 65 years without known CVD.
Psychiatric megatrends and the elderly
Authors: R. M. Glass
Journal: JAMA (1987)

To place the current status of mental health care in context, I would suggest that four psychiatric "megatrends" can be identified from developments in the past decade. First, there has been a marked increase in the reliability of psychiatric diagnosis through the use of explicit diagnostic criteria. This trend served as the basis for the current "official" psychiatric diagnostic system in the United States, the third edition of the American Psychiatric Association's<i>Diagnostic and Statistical Manual of Mental Disorders</i>, known as DSM-III.<sup>1</sup>Second, new emphases on treatment specificity and controlled empirical testing, along with advances in psychopharmacology and psychotherapy, have led to improved treatments for a number of disorders, including both biologic and psychological modalities.<sup>2,3</sup>This progress has also pointed toward a number of areas in great need of further research.<sup>4</sup>Third, recent epidemiologic surveys show convincingly that detectable and differentiable mental disorders are common in the
Total Eclipse
Authors: Lala Tanmoy Das
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PUSTULAE DERMATOSES
Authors: D. S. WILKINSON
Journal: British Journal of Dermatology (1969)

Journal Article PUSTULAE DERMATOSES Get access D. S. WILKINSON D. S. WILKINSON Department of Dermatology, High Wycombe, Buckinghamshire Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 81, Issue s3, 1 June 1969, Pages 38–45, https://doi.org/10.1111/j.1365-2133.1969.tb12853.x Published: 01 June 1969
INDUSTRIAL REGULATION IN INTEREST OF PUBLIC HEALTH.
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
For "With," Read "Without."
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Anticoagulant Therapy After Acute Myocardial Infarction
Authors: Arnold Drapkin
Journal: JAMA (1972)

The value of anticoagulant therapy after acute myocardial infarction has been assessed in 1,136 patients admitted to the Bronx Municipal Hospital Center. The treatment reduced the overall mortality in women from 31% to 15%, particularly those 55 years of age or over, with moderately severe infarction. The low overall mortality in control men (16%) was not reduced with treatment, though there was significant reduction of the mortality in a subgroup of men with moderately severe infarction showing Q-wave evolution. Age and sex, as well as the severity of the episode of acute myocardial infarction, are important in determining whether anticoagulant therapy is likely to be beneficial.
Bias in Environmental Cohort Studies: The Example of Bone Lead and Mortality
Authors: Carol Potera
Journal: Environmental Health Perspectives (2015)

The Example of Bone Lead and MortalityUnrecognized biases in prospective environmental cohort studies may result in under-or overestimating the health effects of the exposure under investigation.In this issue of EHP, researchers examine the problem of bias using data on lead exposure and mortality in men and directed acyclic graphs (DAGs) to illustrate causal relationships between variables that could bias results. 1The study data came from 835 white male participants, average age 67 years, who were part of the Normative Aging Study (NAS), which began in 1963.Between 1991 and 1999, the men had undergone measurement of lead in their patellas.For the current analysis, the researchers looked at associations between patella lead and mortality from all causes, from cardiovascular disease, and from ischemic heart disease.Bone lead, rather than blood lead, is a better biomarker for cumulative environmental exposure, 2 and patella lead in particular has been associated in past studies with risk of ischemic heart disease death. 3he authors used DAGs to visualize relationships among variables that applied to the NAS participants.DAGs link variables with directional arrows to identify those that may bias results.The present study focused on potential errors related to participant selection and participation issues that may affect other cohort studies used in environmental health research.By explicitly visualizing assumptions with DAGs, researchers can identify where bias creeps in and find ways to avoid it. 4"Researchers don't always recognize the assumptions they make when analyzing data," says study leader Marc Weisskopf, an epidemiologist at the Harvard T.H. Chan School of Public Health.As the team analyzed the DAGs, they realized that age at enrollment appeared to be influencing the risk associations.Overall, men with the highest patella lead levels were twice as likely as those with the lowest lead levels to die from ischemic heart disease.
Bronchus-Associated Lymphoid Tissue and the Source of Immunoglobulin-Containing Cells in the Mucosa
Authors: John Bienenstock
Journal: Environmental Health Perspectives (1980)

Bronchus-associated lymphoid tissue has major morphologic and functional similarities to Peyer's patches found in the gut. Both possess a lymphoepithelium with selective antigen sampling properties, both appear in the apparent absence of direct antigen stimulation, both contain a high percentage of cells bearing IgA sdurface immunoglobulin and both can repopulate the bronchial and gut lamina propria with IgA containing cells. Good evidence now exists (and will be reviewed) in support of the concept of a common mucosal immunologic system. Cells potentially sensitized at or in a mucosal tissue such as the gut or lung would then migrate to the draining lymph node, thence into the circulation and localize in a variety of mucosal tissues. Factors involved but not essential for such localization include antigen. Lymphoblasts derived from the lung tend to go back to the lung. Similarly, gut derived lymphoblasts have a predilection for the gut. However, available evidence supports the concept of integrated systemic and mucosal immune systems. Several factors must be taken into account in analysis of the products of local mucosal immune reactions and in developing approaches to achieve optimal humoral immunity at any mucosal surface.
DEPARTMENT OF ERROR
Authors: Bernard Brabin, Jan Maarten Wit, Robin Broadhead, Tom Schulpen, Hugo Heymans
Journal: The Lancet (1999)

frequency of Burkitt's lymphoma in many parts of Africa, little support or research is focused on this condition that, with adequate management and follow-up, can lead to good long-term survival.The cost of expensive cytotoxic drugs, limited medical resources, and lack of experience of treating cancer, because few units in Africa are dedicated to treating children's cancer, make the outcomes and cure rates poor.Adequate follow-up of children is especially d i f f i c u l t .A Medline search for 1998 revealed 85 articles related to Burkitt's lymphoma, nearly all of which reported on molecular studies in western settings.As relevant as these are, an equally important effort is required in African s e t t i n g s .There is a need to translate the approach of the La Mascota Programme, which concentrated on treatment of children with acute lymphoblastic leukaemia, into initiatives in Africa aimed at improving outcome in Burkitt's lymphoma.A preliminary initiative has been started by a Dutch group to support research in Burkitt's lymphoma in Africa.In the words of G Masera and colleagues "the lesson is to show that the gap between resources and their availability where they are most needed can be bridged".
THE CARE OF THE PATIENT IN THE TEACHING HOSPITAL
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Aortic stiffness is associated with aortic and coronary calcification in older adults
Authors: Rachel H. Mackey, Kim Sutton-Tyrrell, Lewis H. Kuller, Barbara L. Naydeck, Anne B. Newman
Journal: Circulation (2001)

P23 Aortic stiffness increases with age and blood pressure, even when the population prevalence of atherosclerosis is low. The extent to which atherosclerosis may exacerbate the aortic stiffening of aging remains unclear. Aortic stiffness was measured by carotid to femoral pulse wave velocity (PWV) and atherosclerosis by coronary artery calcification score (CCS) and aortic calcification score (ACS) by electron beam tomography in 484 participants (42% men, 23% black) aged 70-96 years (mean=79.4) from the Pittsburgh site of the Cardiovascular Health Study. The distributions of PWV (898, 851, 366-2183 cm/sec) (mean, median, range), CCS (676, 327, 0-4954) and ACS (5183, 3040, 0-57,950) were log-transformed when used as continuous variables. Median PWV and ACS were not different by gender but CCS was higher for men than women (median 637 vs. 187, p&lt;0.01). Median PWV did not differ by race. Median CCS and ACS were higher in white participants (392 vs. 132; 3865 vs. 1154, p&lt;0.01 for both). After adjustment for age and mean arterial pressure (MAP), PWV was higher for higher quartiles of CCS in women (792, 862, 854, 906, p for trend=0.02), but not men (879, 838, 888, 886, p for trend=0.67). Mean PWV was also higher by quartile of ACS (844, 918, 915, 942, p for trend=0.04) for the total group after adjustment for age, sex and MAP. When stratified by sex, the association was significant only for women (805, 861, 903, 933, p for trend=0.02), not men (910, 1021, 939, 966, p for trend=0.72). Similar results were found using linear regression with log CCS or log ACS as the independent variable, even after excluding participants with prevalent clinical disease. Race did not affect the associations. In these older adults, we found a cross-sectional association between aortic stiffness (PWV) and aortic and coronary calcification, independent of age and MAP, largely due to an association in women. The lack of association in these older men may be due to low power or survival bias. It will be important to determine whether aortic stiffness is an independent predictor of myocardial infarction and congestive heart failure, especially in conjunction with coronary calcification as a measure of atherosclerosis.