tbuckley/cabot-search huggingface dataset:
Advance Directives
Authors: James G. Adams
Journal: JAMA (1992)

<h3>To the Editor.</h3> —We risk caring more for paper than patients if we too literally interpret advance directives. It is important, then, if unfortunate, that the article by Sehgal et al<sup>1</sup>asks how strictly patients wish to have advance directives followed. On the one hand, such questions advocate the importance of the physician-patient relationship. The article encourages physicians to ask patients "what factors they want considered in making decisions for them," demonstrating the importance of ongoing, honest conversation. On the other hand, asking patients "how strictly they want their advance directive followed" forces the patient to cover all bases and address an almost infinite number of possible variations. The compassionate and open discussion of the patient's values, beliefs, attitudes, and outlook would be more effective. Patients, reassured that their perspective, comfort, and prognosis will be considered, can allow the physician and surrogate to direct their care when necessary. In
Surgical Endocrinology
Authors: R Q PASQUALINI
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Course of Lectures on Urine, Urinary Deposits, and Calculi
Authors: L. Beale
Journal: BMJ (1860)

Urinaty Deposits associated with Urates.Urates in Urine, without formting a Deposit: Albumen present.Atnalyses of Deposits of Urates.Puts.Characters of the Urinle.Tests for Pus.Of the Presence of Pus in Urinie, in a Clinical Point of View.Earthy Phosphates.Triple or Ammoniaco-Magntesian Phosphate.Tests.Phosphate of Lime.Phosphate of Lime, in the form of Spherules and Small Dumb-Bells.Pecultiar Form of Phosphate, usually regarded as consisting of Triple Phosphate.On the Crystalline Form of Phosphate of Lime.Ill.-SECOND CIASS OF URINARY DEPOSITS.GENTLEMEN,-We now come to the consideration of the second class of deposits, which form a bulky, dense, opaque, and often abundant precipitate, which sinks to the bottonm of the vessel, leaving a perfectly clear, or more or less turbid, supernatant fluid.Pu3, Urates, Phosphates.The most important deposits of this class are those consisting of urate of soda, ptls, anld earthy phosphate.To the practitioner these three deposits are especially interesting; and, as their presence in the urine is characteristic of important morbid conditions differing widely in their results from each other, while the appearance of the deposits to the naked eye is very similar, it is a matter of great importance that the practitioner should be able to distinguish them from each other with certainty, aud at the same time with facility.Before entering, therefore, upon a detailed description of these bodies, let me draw your atten.'tion to an exceedingly simple method of distinguishing them.Let the clear supernatant fluid.be poured off, and a little of the deposit be transferred to a test-tube.Upon the addition of about half the bulk of solution of potash, one of the three following points will be noted:-No change will be produced, in which case the deposit consists entirely of phosphate.Se- condly, the mixture will become clear, and very stringy or viscid, so that it cannot be poured from the test-tube in drops.In this case, we may be certain that the deposit consists of piw.Thirdly, the solution of potash may cause the mixture to become clear, but not viscid, in which case urate of soda and ammonia enter ve-ry largely into the composition of the deposit.Often liquor potassm gelatinises the mixture, but does not render it clear, in which case it is probable that both ,pus and phosphates are present.In any of the above instances, our conclusion as to the nature of the substance sbould be confirmed by some of the tests presently to be mentioned, and by microscopical examinatian.Urates.
Association Between Aortic Stenosis and Facies of Severe Infantile Hypercalcemia
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Erratum for the Research Article: “Neoadjuvant chemotherapy induces breast cancer metastasis through a TMEM-mediated mechanism” by G. S. Karagiannis, J. M. Pastoriza, Y. Wang, A. S. Harney, D. Entenberg, J. Pignatelli, V. P. Sharma, E. A. Xue, E. Cheng, T. M. D’Alfonso, J. G. Jones, J. Anampa, T. E. Rohan, J. A. Sparano, J. S. Condeelis, M. H. Oktay
Journal: Science Translational Medicine (2017)
Dose-Response Relationship in Radiogenic Breast Cancer: Reply
Authors: Irwin D. J. Bross
Journal: JNCI Journal of the National Cancer Institute (1978)

Journal Article Dose-Response Relationship in Radiogenic Breast Cancer: Reply Get access Irwin D. J. Bross, Ph.D. Irwin D. J. Bross, Ph.D. Director of Biostatistics Roswell Park Memorial Institute Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 60, Issue 4, April 1978, Pages 729–730, https://doi.org/10.1093/jnci/60.4.729 Published: 01 April 1978
The passive voice
Authors: C. G. Roland
Journal: JAMA (1967)

"During the years 1948 through 1953, some 120 children were seen in private practice. Of this number, 16 were adopted." A recent communication began with these sentences. What do they mean? Perhaps the writer personally adopted 16 of the 120 children he examined between 1948 and 1953. Of course, other interpretations exist. Further reading of the published article reveals that its author meant this: Between 1948 and 1953, he examined 120 children from his private practice. Sixteen of these children were not the offspring of their present parents, who had adopted them. This example illustrates one of the commonest problems afflicting medical writing, one which you should learn to recognize, and avoid: the passive voice. What is the passive voice? Grammatically, it consists of some form of the verb "to be" plus a past participle, and shows whether a subject performs or receives the action expressed by the verb. In
Ultrasonographic Screening for Deep Venous Thrombosis after Arthroplasty
Authors: Vijay Rajput
Journal: Annals of Internal Medicine (1998)

Letters1 April 1998Ultrasonographic Screening for Deep Venous Thrombosis after ArthroplastyVijay Rajput, MD and Vipul Nanavati, BSMEVijay Rajput, MDRobert Wood Johnson Medical School; Camden, NJ 08103Search for more papers by this author and Vipul Nanavati, BSMERobert Wood Johnson Medical School; Camden, NJ 08103Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-7-199804010-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:It is interesting that Robinson and colleagues' study [1] shows a rate of deep vein thrombosis after hospital discharge (2.5%) that is lower than the rates reported by Planes [2] and Bergqvist [3] and their colleagues. The main reason for the lower incidence in Robinson and coworkers' study is the inclusion of only proximal deep venous thrombosis as diagnosed by ultrasonography. In contrast, the other two studies included both proximal and distal deep venous thrombosis diagnosed by venography. The incidence of proximal deep venous thrombosis is similar in all three studies, but undiagnosed distal deep venous thrombosis ...References1. Robinson KS, Anderson DR, Gross M, Petrie D, Leighton R, Stanish W, et al. Ultrasonographic screening before hospital discharge for deep venous thrombosis after arthroplasty: The Post-Arthroplasty Screening Study. A randomized, controlled trial. Ann Intern Med. 1997; 127:439-45. Google Scholar2. Planes A, Vochelle N, Darmon JY, Fagola M, Bellaud M, Huet Y. Risk of deep-venous thrombosis after hospital discharge in patients having undergone total hip replacement: double-blind randomised comparison of enoxaparin versus placebo. Lancet. 1996; 348:224-8. Google Scholar3. Bergqvist D, Benoni G, Bjorgell O, Fredin H, Hedlundh U, Nicolas S, et al. Low-molecular-weight heparin (enoxaparin) as prophylaxis against venous thromboembolism after total hip replacement. N Engl J Med. 1996; 335:696-700. Google Scholar Author, Article, and Disclosure InformationAuthors: Vijay Rajput, MD; Vipul Nanavati, BSMEAffiliations: Robert Wood Johnson Medical School; Camden, NJ 08103 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1998Volume 128, Issue 7Page: 601KeywordsArthroplastyCoumarinsDeep vein thrombosisLow molecular weight heparinProphylaxisUltrasound imaging ePublished: 15 August 2000 Issue Published: 1 April 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
PDTM-40. PEDIATRIC LOW-GRADE GLIOMAS WITH CRAF GENE FUSIONS ARE THERAPEUTICALLY DISTINCT FROM BRAF-FUSIONS BASED ON DIMERIZATION MEDIATED BY N-TERMINAL FUSION PARTNER.
Authors: Payal Jain, Tamara Fierst, Harry Han, Tiffany Smith, Phillip B Storm, Angela J Waanders, Adam C Resnick
Journal: Neuro-Oncology (2017)

Pediatric low-grade gliomas (PLGGs) are the most common brain tumors in children mainly defined by activating gene fusions that dysregulate the mitogen-associated protein kinase (MAPK) pathway. Our lab has characterized PLGG-associated KIAA1549-BRAF gene fusion along with response to targeted MAPK inhibitors. We have since gone on to explore non-BRAF gene fusions, specifically CRAF (or RAF1) fusions, QKI-RAF1 and SRGAP3-RAF1, as potential PLGG driver mutations. As CRAF and BRAF are shared targets of MAPK therapeutics, we sought to investigate the mechanistic and response of CRAF-fusions to clinically relevant RAF inhibitors (RAFi) and downstream pathway inhibitors. We focused on the role of N-terminal fusion partners and RAF dimerization for successful targeting. Using heterologous model systems, we found that CRAF-fusions do not respond to RAFi, show partial response to single-agent MEKi, but robustly respond to combinatorial targeting of both MAPK and PI3K pathways and novel RAF dimer inhibitors. Upon comparing the homo- and hetero-dimerization profiles of QKI-RAF1and BRAF-fusions in the presence of RAFi, we found that QKI-RAF1 retains robust homo- and hetero-dimerization that, in contrast, are disrupted in BRAF fusions that respond to RAFi. Interestingly, we found that CRAF-fusions’ dimerization is unaffected primarily due to robust protein-protein interactions mediated by the non-kinase N-terminal fusion partner, such as QKI. This suggests that dimerization is essential for MAPK pathway activation and determines responsiveness to RAFi. Furthermore, we found that the novel RAF dimer inhibitor, LY3009120, stabilized CRAF-fusions in an inactive dimer conformation and suppressed oncogenic potential. Overall, CRAF-fusions are distinct from BRAF-fusions in responsiveness to targeted therapies, especially due to effect of N-terminal fusion partner in mediating stable dimerization. Our study suggests that molecular classification of PLGGs should inform therapeutic intervention of RAF-altered PLGGs even within RAF-mutant subtypes.
Cancer Epidemiology
Authors: Melissa Bondy
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Myasthenia gravis associated with wasp sting
Authors: J. Brumlik
Journal: JAMA (1976)

A clinical picture indistinguishable from, but not therefore identical with, myasthenia gravis (ocular form) developed within 24 hours of a wasp sting. Because of the close temporal association of events, operative mechanisms may be either an immediate hypersensitivity reaction to some components of wasp venom or a direct toxic effect of these substances on acetylcholine synthesis, release, or degradation. Theoretical considerations from the literature and the lack of immunologic abnormalities in the patient suggest that the latter may be correct. Unique host conditions must have been present at the time of the sting, implying latent or subclinical myasthenia gravis. (<i>JAMA</i>235:2120-2121, 1976)
VENOUS THROMBOSIS AS A COMPLICATION OF CARDIAC DISEASE.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Impact of Genomic Alterations on Outcomes in Myelofibrosis Patients Undergoing JAK1/2 Inhibitor Therapy
Authors: Jay Spiegel, Caroline Jane McNamara, Andrea Arruda, Tony Panzarella, James A. Kennedy, Tracy L. Stockley, Mahadeo Sukhai, Mariam Thomas, Justyna Bartoszko, Jenny M. Ho, Nancy Siddiq, Aaron D. Schimmer, Andre C. Schuh, Hassan Sibai, Karen W.L. Yee, Jaime O. Claudio, Rebecca Devlin, Mark D. Minden, Suzanne Kamel-Reid, Vikas Gupta
Journal: Blood (2016)
Third International Conference on Adjuvant Therapy of Breast Cancer
Journal: JNCI Journal of the National Cancer Institute (1987)

Journal Article Third International Conference on Adjuvant Therapy of Breast Cancer Get access JNCI: Journal of the National Cancer Institute, Volume 79, Issue 1, July 1987, Page 197, https://doi.org/10.1093/jnci/79.1.197-c Published: 01 July 1987
THE CLINICIAN VIEWS ENDOCARDIAL FIBROELASTOSIS
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Generalised seizure due to terfenadine.
Authors: P Tidswell, A d'Assis-Fonseca
Journal: BMJ (1993)

Queen Alexander Hospital, Ports- mouth) write: We report a case of reversible opiate toxicity to Tylex not previously described.An 86 year old woman with chronic lung disease collapsed and was brought to the casualty department.She was unresponsive, cyanosed with minimal respiratory effort, and hypotensive.She displayed small pupils with no other abnormal neurological signs and had bilateral basal respiratory crackles.Her electrocardiogram and chest radiograph showed nothing abnormal, and blood gas measure- ment confirmed she was acidotic ([H+i 56-6 nmol/l), hypercapnic (Pco2 10 6 kPa), and hypoxic
More 'salt' talks: diet and hypertension
Authors: L. Newman
Journal: JAMA (1982)

Conventional wisdom regarding the causes, prevalence, and treatment of hypertension was challenged by experts at a recent symposium on nutrition and BP control in Arlington, Va. The three-day meeting was jointly sponsored by the National Kidney Foundation, the Department of Health and Human Services, and the International Life Sciences Institute, Washington, DC. (The latter is an industry-supported organization that says it "provides for liaison between scientists from national regulatory agencies, concerned industries, research institutes, and universities" in establishing the safety of food, drug, and cosmetic ingredients and other chemicals.) Much attention was paid to the growing controversy over sodium intake and its relationship with high BP. John H. Laragh, MD, Hilda Altschul Professor of Medicine and director of the cardiovascular center and the hypertension center at New York Hospital-Cornell Medical Center, criticized the recent public health initiatives by the federal government to reduce sodium in the American diet, calling these
Unlike HbA1c level and the amount of visceral adipose tissue, the presence and severity of NAFLD do not predict the occurrence of major adverse cardiovascular events in an obese Belgian population
Authors: Mikhail Van Herck, Christophe Conrad, Simon Kleevens, Christophe De Block, Eveline Dirinck, Luc Van Gaal, An Verrijken, Vincent Segers, Emeline Van Craenenbroeck, Ann Driessen, Peter Michielsen, Toon Steinhauser, Thomas Vanwolleghem, Jonas Weyler, Luisa Vonghia, Sven Francque
Journal: Journal of Hepatology (2020)
Correspondence
Authors: Mindie Nguyen, Khoa Lam
Journal: Hepatology (2011)

We appreciate Yu's interest and comments regarding the definition of early virological response (EVR) in our recent article on hepatitis C virus (HCV) genotype 6 therapy.1 We defined EVR as an undetectable HCV RNA level at week 12. In the study, all patients who achieved partial EVR (defined as a 2-log10 decline in the baseline HCV RNA level) also achieved complete EVR, and a separate analysis of these two treatment endpoints would not have yielded additional information. We appreciate the opportunity to make this clarification. Mindie Nguyen M.D.*, Khoa Lam M.D. , * Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University Medical Center, Palo Alto, CA, Pacific Health Foundation, San Jose, CA, Department of Medicine, University of California San Francisco, San Francisco, CA.
Effects of new 1993 criteria for classification of AIDS
Authors: J. F. Fries
Journal: JAMA (1993)

<h3>To the Editor.</h3> —On January 1,1993, the revised classification system for human immunodeficiency virus (HIV) infection and expanded surveillance case definition for acquired immunodeficiency syndrome (AIDS) went into effect.<sup>1</sup>With the new criteria, individuals with a CD4 cell count of less than 0.20×10<sup>9</sup>/L (200/μL) or a CD4 percentage of less than 14% are classified as having AIDS even in the absence of a defining opportunistic infection or indicator disease. The list of defining conditions was augmented by inclusion of pulmonary tuberculosis, bacterial pneumonia, and cervical cancer. Many implications for insurance coverage, clinic eligibility, and other social factors, as well as medical ones, result from this change. For example, it may be anticipated that survival for AIDS patients will artificially increase, and the point prevalence of disability and decreased quality of life in AIDS patients will become somewhat less. It is important to recognize the magnitude of these