tbuckley/cabot-search huggingface dataset:
Intrahepatic cholangiographic appearance simulating primary sclerosing cholangitis in several hepatobiliary diseases: A postmortem cholangiographic and histopathological study in 154 livers at autopsy
Authors: T TERADA
Journal: Hepatology (1995)

Intrahepatic cholangiography of primary sclerosing cholangitis (PSC) is characterized by stricture with or without dilation of the biliary tree. To evaluate whether this cholangiographic appearance is present in non-PSC livers as well as the histological features seen in non-PSC livers with this cholangiographic appearance, we performed postmortem intrahepatic cholangiography in 154 liver autopsy specimens. The PSC-like cholangiographic appearance was frequently found in cirrhosis with or without hepatocellular carcinoma (4 of 6, 67%), hepatocellular carcinoma (1 of 1,100%), adult-type polycystic disease of the liver and kidneys (2 of 3,67%), submassive hepatic necrosis (2 of 5, 40%), amyloidosis (1 of 2, 50%), and intrahepatic extensive thrombosis (1 of 1, 100%). It was also found but at lower frequency in metastatic carcinomas (3 of 13,23%) and leukemia/lymphoma infiltration (2 of 12, 17%). Histologically, in livers with such a PSC-like cholangiographic appearance, the intrahepatic bile ducts were compressed by fibrosis, inflammatory infiltrates, liver cysts, cancer cell infiltration, amyloid deposition, or portal thrombi. Dilated ducts had less pronounced changes than strictured ducts. In these hepatobiliary diseases, the changes of intrahepatic bile ducts in the livers without the PSC-like cholangiographic appearance were much less marked than those in the livers with it. These data suggest that the PSC-like intrahepatic cholangiographic appearance is present in several hepatobiliary diseases and that clinicians should take such diseases into consideration if stricture with or without dilation is found on intrahepatic cholangiography. (HEPATOLOGY 1995;22:75–81).
A Correction
Journal: BMJ (1907)

TvMPANU-M would be obliged for information as to the effect of thiosinamin on cicatricial thickening of the tympanum, and the strength of the drops to be used.RUSTICUS would be grateful for suggestions for a stimulating substitute for alcohol in a man who cannot afford to take alcohol, but who in his worrying work occasionally feels he mnust have a " pick-me-up " and would gladly take something which would not produce any craving
Addition of Cyclophosphamide, on Demand, to Lenalidomide and Corticosteroids in Patients with Relapsed/Refractory Multiple Myeloma, a Retrospective Review of a Single Centre Experience
Authors: Majed Alahmadi, Esther Masih-Khan, Eshetu G Atenafu, Limore Arones, Christine Chen, Vishal Kukreti, Rodger Tiedemann, Suzanne Trudel, Anca Prica, Donna Reece
Journal: Blood (2015)
PROGRAM TWENTY-FOURTH ANNUAL SESSION AMERICAN COLLEGE OF PHYSICIANS CLEVELAND, OHIO
Journal: Annals of Internal Medicine (1940)

Article1 February 1940PROGRAM TWENTY-FOURTH ANNUAL SESSION AMERICAN COLLEGE OF PHYSICIANS CLEVELAND, OHIOAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-13-8-1534 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptApril 1-5, 1940GENERAL SESSIONS AND LECTURESO. H. Perry Pepper, PresidentCLEVELAND COMMITTEE ON ARRANGEMENTSHoward T. Karsner, General ChairmanEdward H. Cushing E. P. McNameeHarold Feil V. C. RowlandJoseph M. Hayman, Jr. John A. ToomeyCOMMITTEE ON CLINICS AND DEMONSTRATIONSJoseph M. Hayman, Jr., ChairmanSamuel S. Berger Harry V. ParyzekRussell L. Haden Robert M. StecherFred C. Oldenburg Charles T. WayHarley A. WilliamsCOMMITTEE ON TRANSPORTATIONEdward H. Cushing, ChairmanMcKinley London J. C. PlacakCOMMITTEE ON ENTERTAINMENTE. P. McNamee, ChairmanF. A. LeFevre H. D. PiercyJ. P. TuckerCOMMITTEE ON This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAccommodating Discrimination 1 February 1940Volume 13, Issue 8Page: 1534-1553 ePublished: 1 December 2008 Issue Published: 1 February 1940 PDF downloadLoading ...
GLAUCOMA.
Authors: DUDLEY S. REYNOLDS
Journal: JAMA (1898)

The term glaucoma, which formerly meant sea-green pupillary reflex; with more or less complete blindness, described by Walther as a condition in which the patient sees nothing and the surgeon likewise nothing, has come to mean so much that it now really means nothing definite. The nearest approach I could come to a location of the structural lesions which give rise to the symptoms of glaucoma would be the ciliary region of the eye. As a matter of fact, disturbances in the nutrition of the ciliary muscle, with or without corresponding disturbances in the ciliary body, presenting all the varying characteristics from a reflex hyperemia to a fulminating parenchymatous inflammation, give rise to some degree of ocular tension, accompanied by undue fulness of the retinal veins and some degree of depression of the surface of the optic disc. Perimetric registration may be required to complete the diagnosis in some mild
THE VON PIRQUET STANDARD OF NORMAL BODY WEIGHT AS COMPARED WITH OTHER STANDARDS
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
NIGHT WORKING.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Analysis of Anaphase in Cell Culture: An Adequate Test System for the Distinction between Compounds Which Selectively Alter the Chromosome Structure or the Mitotic Apparatus
Authors: R. Rocio Coutino
Journal: Environmental Health Perspectives (1979)

A system of anaphase analysis is presented as an adequate test to detect aberrations in chromosome structure and alterations in the mitotic apparatus.Particular emphasis is placed on those data which suggest that proteins may be the preferred targets of chemical compounds that induce aneuploidy.
END OF THE SCHLATTER CASE OF GASTRIC EXTIRPATION.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
137TiP A phase III study of alpelisib and fulvestrant for hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2–) advanced breast cancer (ABC) progressing on or after aromatase inhibitor (AI) therapy (SOLAR-1)
Authors: H. Iwata, G. Rubovszky, S. Loibl, E. Ciruelos, M. Campone, D. Juric, H. Rugo, I. Mayer, P.F. Conte, B. Kaufman, K. Inoue, H. Tesch, Y-S. Li, I.D. Mingorance, L. Ryvo, H. Iwase, A-S. Longin, D. Mills, C. Wilke, F. André
Journal: Annals of Oncology (2016)
To Seek, per <i>Chance</i> to Find
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nitric Oxide and Sepsis
Authors: Robert Kilbourn
Journal: JAMA (1996)

<h3>To the Editor.</h3> —Drs Cobb and Danner<sup>1</sup>describe 2 case reports and provide an overview of the literature that is presented in an unbalanced perspective and is inconsistent with the available knowledge in the field. Although the review quotes many references, much of the basis for the conclusions are from 2 experiments, both originating from the authors' own laboratory. As a result, the authors tend to look at the field as a whole in the perspective of these 2 reports, which have major flaws. First, the dose of endotoxin used to induce lethality is 400 times greater than the dose that causes moderate to severe hypotension in dogs. Indeed, the same group worked diligently for years to develop a sepsis model using an intraperitoneal septic clot that more closely simulates the human cardiovascular response than the endotoxin bolus model. Interestingly, when they finally used the clot model to study
Archives of Otolaryngology, Chicago
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Incidence of thyroid disorders in Connecticut
Authors: D. B. Baldwin
Journal: JAMA (1978)

A prospective study involving 1,544 patients who had annual physical examinations during a one-year period was conducted to determine the incidence of thyroid abnormalities in a practice of general internal medicine. A total of 5.8% abnormalities were found including nodular disease, thyroiditis, Graves' disease, hypothyroidism, simple goiter, and iatrogenic hyperthyroidism. No thyroid cancer was detected. (<i>JAMA</i>239:742-744, 1978)
Authors’ Reply
Authors: Sanjeev Sethi, Vincent Rajkumar, Vivette D. D'Agati
Journal: Journal of the American Society of Nephrology (2018)

We thank Kousios et al.1 for their comments on monoclonal Ig–associated renal diseases in the setting of smoldering multiple myeloma (SMM). In their letter, they express concern that a diagnostic gap may be created if such patients are excluded from monoclonal gammopathy of renal significance (MGRS). We would like to clarify that the term MGRS does not exclude SMM. As we state in our paper, MGRS refers to renal disorders caused by a monoclonal Ig “in the absence of hematologic malignancy or other myeloma-defining events.”2 Although the main premalignant plasma cell disorder responsible for most cases of MGRS is monoclonal gammopathy of undetermined significance in the setting of a small clonal proliferation, the term MGRS also includes similar renal injury that occurs in the setting of SMM, smoldering Waldenström macroglobulinemia, or monoclonal B cell lymphocytosis. It is possible that Kousios et al.1 were concerned that, in figure 1 in our paper,2 SMM appears under the category of “malignant” plasma cell disorders. We placed SMM in the “malignant” category to indicate the emerging concept that approximately 50% of patients with high-risk SMM are considered to have early malignancy and are being offered therapy with antimyeloma treatments in the absence of myeloma-defining events.3 The definition of MGRS will evolve over time, and it will even evolve in the individual patient. Thus, if the underlying plasma cell disorder in a patient with MGRS progresses to multiple myeloma, Waldenström macroglobulinemia, or malignant lymphoma, it will not be considered (or require a reason to be considered) as having MGRS. Similarly, as the strategy of using antimyeloma therapy for selected patients with SMM evolves, patients in whom therapy targeting the plasma cell clone is indicated will not be considered (or will require a reason to be considered) as having MGRS. Disclosures None.
Abstract 1498: Agonist-modulated Activation of AMP-activated Protein Kinase: Evidence for a Novel AMPK-Rac1-Akt-eNOS Pathway in Endothelial Cells
Authors: Yehoshua Levine, Thomas Michel
Journal: Circulation (2007)

The endothelial isoform of nitric oxide synthase (eNOS) is regulated by diverse cell surface receptors. Activation of eNOS by vascular endothelial growth factor (VEGF) and sphingosine 1-phosphate (S1P) involves multiple protein kinases and other signaling proteins, yet the relationships between these pathways are incompletely understood. We designed and validated a series of potent and specific duplex siRNA constructs to knockdown expression of key signaling proteins in bovine aortic endothelial cells, and have identified a novel AMPK-Rac1-Akt hierarchical pathway that is critical for VEGF- and S1P-modulated eNOS activation and angiogenesis. We found that VEGF (10 ng/ml) and S1P (100 nM) promote a rapid ~4-fold increase in AMPK phosphorylation. siRNA constructs targeting AMPKα1 specifically suppress AMPKα1 expression by &gt;90%, and markedly impair agonist-mediated eNOS activation (49 ± 14% decrease in VEGF-induced eNOS activity; 43 ± 19% decrease for S1P; n = 4, p &lt; 0.05 for both by ANOVA) as well as Akt phosphorylation (38 ± 6% reduction for VEGF; 42 ± 7% reduction for S1P; n = 4, p &lt; 0.01). In contrast, siRNA-mediated Akt1 knockdown attenuates eNOS activation but does not affect AMPK activation. These results establish that AMPK lies upstream of Akt in the pathway leading from receptor to eNOS. siRNA-mediated AMPKα1 knockdown attenuates agonist-mediated activation of the small GTPase Rac1 (51 ± 19% decrease; n = 3, p &lt; 0.05). Conversely, Rac1 siRNA decreases the phosphorylation of AMPK substrates without affecting phosphorylation of AMPK, implicating Rac1 as an effector of AMPK in eNOS activation. siRNA-mediated knockdown of caveolin-1 significantly enhances AMPK phosphorylation, suggesting that AMPK is negatively regulated by caveolin-1. Finally, we found that cells transfected with AMPK, Rac1, or eNOS siRNA demonstrate severely impaired agonist-modulated endothelial migration and tube formation on Matrigel. These results suggest that VEGF and S1P regulate AMPK as a very key early step in an agonist-modulated AMPK → Rac1 → Akt hierarchy that controls eNOS activation as well as cell migration and endothelial tube formation. These findings may have important implications for the AMPK-dependent control of NO signaling pathways in the vascular wall.
Visible alternatives.
Journal: BMJ (1967)

ArticlesBRIT that, today, the parents who bring up a subnormal baby themselves are likely to have a hard time of it."3The report examines the procedure whereby the school medical officer, acting on behalf of the local education authority, assesses children who may be subnormal at the age of about 5. It points out that no matter how skilfully this assessment is made the objective is primarily administrative and is directed at excluding the child from school rather than at making a constructive educational or therapeutic recommendation.The report also emphasizes the inadequacy of a single assessment at a single point in time.Child psychiatry has long recognized the value of the multidisciplinary team approach for the diagnosis, assessment, and management of childhood disorders.This important concept is adopted and extended by the working party.Its view is that the assessments should be undertaken by such a team working in a co-ordinating centre planned and staffed jointly by the local authority and the National Health Service.The staff of such a centre should include medical specialists, educationalists, psychologists, social workers, and possibly parents.The team should work in co-operation with general practitioners and hand on information to them.Such an arrangement would give a family access to a centre where they could obtain authoritative diagnosis and assessment of subnormality and other handicaps, and under the same roof the accumulated knowledge of social and personal problems could be applied for the benefit of individual cases.The report describes how provisions for the care and management of handicapped children vary from area to area throughout Britain.Greater co-operation between local authorities, hospital authorities, and voluntary societies is necessary before services can be integrated and rationalized so that more effective use is made of existing resources.Essential services such as pre-school facilities for subnormal children, training centres, and accommodation for short-term residential care to cover holidays or family crises are missing or inadequate in some parts.Planning for the future should
IRON AND BLOOD REGENERATION
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Management of fluid retention in patients with advanced cancer
Authors: C. Flombaum
Journal: JAMA (1981)

SODIUM retention and fluid accumulation manifested as edema are common in cancer patients.<sup>1</sup>This is usually secondary to pooling of fluids in a third space as occurs in ascites, pleural effusion, dependent edema secondary to obstruction of the inferior vena cava or lymphatics, peritonitis, or ileus. This abnormal accumulation of extracellular fluid is physiologically unavailable and results in a decreased effective circulating blood volume. Hyponatremia is common, but on a "dry weight" basis there is extra body sodium. A state of chronic protein depletion is common in cancer patients because of loss of protein into the malignant effusions and repeated drainage of these protein-rich fluids, loss of protein in diarrhea and external fistulae (especially pancreatic), decreased food intake and malnutrition, and hypercatabolism as a result of sepsis. Hypoalbuminemia with consequent decreased plasma oncotic pressure leads to a decreased plasma volume and facilitates the escape of fluid to these third
ABSTRACTS
Journal: Circulation (1950)

The authors found that persons with nutritive failure have a blood pressure which is usually below normal and which tends to rise slowly as the nutri- tive failure is corrected.The effect of desoxycorticosterone acetate in such hypotensive patients was determined by adminis- tration of this substance daily in varying dosage.After the third day, the patients complained of tightness of the skin around the ankles.There was a prompt increase in blood pressure readings and in body weight, and when the drug was discontinued, the blood pressure readings promptly returned to normal.While the findings are of general interest, the authors do not recommend the use of desoxycorticosterone acetate as a therapeutic agent for hypotension.