tbuckley/cabot-search huggingface dataset:
Traumatic Fibrositis
Authors: G. Slot
Journal: Annals of the Rheumatic Diseases (1940)

A LARGE number of disability certificates are signed every week for industrial workers suffering from fibrositis.It has been noticed that some of these have been associated with their occupations.They can be classified:1. Fibrositis of Neck Mu8cles.-Thisincludes market porters, especially fish and vegetable porters, who carry heavy weights on their heads-the-weight of the contents of their pile of baskets may reach between 50 and 100 pounds.Taxi drivers and lorry drivers are also represented in this group.2. Fibrositis of Arm and Hand Muscles.-This group includes bus conductors, locomotive firemen, gardeners, and dustmen.3. Fibrositis of the Back and Gluteal Muscles.-Sufferers from this form the largest group of occupational fibrositis.It includes bus drivers, miners, policemen, gardeners, milk roundsmen with heavy trolleys to push, tram drivers, iron workers, and stokers.Women engaged in lifting (shop and warehouse workers) are often among the group.4. Fibrositis of the Foot Muscles.-This is a difficult group to classify, as foot defects-pes planus, etc.-should be separated.Arthritis of the feet is common, as also is referred pain from a sciatic lesion.Foot strain is a common association.The em- ployments especially liable to this condition are shop girls who have to stand for long periods of time, recruits in the Army, and bus, lorry, and locomotive drivers.The common factor in these varied conditions is muscle fatigue and trauma.The trauma may ber slight but recurrent.The setiology of these conditions is obscure, and because the con- dition is non-fatal, proof by biopsy can seldom be made.Other common factors are heat, humidity, and exposure to cold.The pathology may show small nodules under the skin-it is difficult to excise these as they slip away from under the forceps.On examination they are found to consist of small aggregations of round cells and fibrous tissue.Though various workers have tried to grow organisms from
The BMA's annual representative meeting There must be more short stay beds The meeting.. Seniors and juniors unite on workload BMA divisions continue to be supported The meeting .. Doctors are haemorrhaging from the NHS Medical schools at saturation point The meeting .. BMA stress service receives nearly 800 calls Academic medicine is in crisis BMJ reaches 300 000 readers Doctors should not endorse gun licence applications The meeting .. Meeting criticises new asylum bill Doctors should boycott…
Authors: L. Beecham, J. Smith
Journal: BMJ (1996)
EGFR PHOSPHORYLATION OF DCBLD2 RECRUITS TRAF6 AND STIMULATES AKT-PROMOTED TUMORIGENESIS
Authors: S. Cheng, H. Feng, G. Y. Lopez, C. K. Kim, C. G. Duncan, A. Alvarez, R. Nishikawa, M. Nagane, A.-J. Su, P. E. Auron, M. L. Hedberg, L. Wang, J. R. Grandis, R. E. McLendon, D. D. Bigner, I. Nakano, K. Joshi, S. Kim, H.-K. Lin, F. B. Furnari, W. K. Cavenee, B. Hu, H. Yan, S.-Y. Cheng
Journal: Neuro-Oncology (2014)

BACKGROUND: Oncogenic EGFR-Akt signaling is aberrantly activated in human glioblastomas. Discoid, CUC and LCCL domain containing protein 2 (DCBLD2, also known as CLCP1 and ESDN) is a neuropilin-like membrane protein that is up-regulated in vascular injury and metastatic lung cancers. However, the role of DCBLD2 in cancer is unclear. METHODS: We examined the expression of DCBLD2 in TCGA and other data bases of clinical glioma specimens. We assessed the effects of knockdown of endogenous DCBLD2 and re-express mutated DCBLD2 in glioma cells expressing EGFRvIII in vitro and in vivo. We performed IP-WB analyses to examine EGFR-induced tyrosine phosphorylation and DCBLD2 association with TRAF6. We also examined the impact of TRAF6 in EGFRvIII_driven tumorigenesis and association of p-Y EGFR and p-Y750 of DCBLD2 with tumor prognosis. We used patient-derived glioma stem cells, primary shortern culture GBM cells and established glioma cell lines in vitro, orthotopic brain glioma xenografts, various biochemical methods and IHC analysis of de-identified clinical tumor specimens of glioma samples and HNC smaples in our study. RESULTS: We found that DCBLD2 is up-regulated gene in glioblastomas and head and neck cancers (HNCs) and is required for EGFR-stimulated tumorigenesis. EGFR induces tyrosine phosphorylation (p-Y) of DCBLD2 including in a Y750 residue within a binding motif for TNF receptor-associated factor 6 (TRAF6). Consequently, the induced p-DCBLD2Y750 recruits TRAF6 to DCBLD2. This association causes increased TRAF6 E3 ligase activity and subsequent activation of Akt, thereby enhancing EGFR-driven tumorigenesis. CONCLUSIONS: Our findings uncover a novel pathway by which DCBLD2 functions as a signal relay for oncogenic EGFR signaling in promoting tumorigenesis, a conclusion that is supported by the association of EGFR activation and DCBLD2 phosphorylation with poor prognoses for gliomas and HNCs. These data also nominate DCBLD2 and TRAF6 as attractive therapeutic targets for human cancers that are associated with EGFR activation. SECONDARY CATEGORY: n/a.
Inhibition of growth hormone action improves insulin sensitivity in liver IGF-1–deficient mice
Authors: Shoshana Yakar, Jennifer Setser, Hong Zhao, Bethel Stannard, Martin Haluzik, Vaida Glatt, Mary L Bouxsein, John J. Kopchick, Derek LeRoith
Journal: Journal of Clinical Investigation (2004)

Liver IGF-1–deficient (LID) mice have a 75% reduction in circulating IGF-1 levels and, as a result, a fourfold increase in growth hormone (GH) secretion. To block GH action, LID mice were crossed with GH antagonist (GHa) transgenic mice. Inactivation of GH action in the resulting LID + GHa mice led to decreased blood glucose and insulin levels and improved peripheral insulin sensitivity. Hyperinsulinemic-euglycemic clamp studies showed that LID mice exhibit severe insulin resistance. In contrast, expression of the GH antagonist transgene in LID + GHa mice led to enhanced insulin sensitivity and increased insulin-stimulated glucose uptake in muscle and white adipose tissue. Interestingly, LID + GHa mice exhibit a twofold increase in white adipose tissue mass, as well as increased levels of serum-free fatty acids and triglycerides, but no increase in the triglyceride content of liver and muscle. In conclusion, these results show that despite low levels of circulating IGF-1, insulin sensitivity in LID mice could be improved by inactivating GH action, suggesting that chronic elevation of GH levels plays a major role in insulin resistance. These results suggest that IGF-1 plays a role in maintaining a fine balance between GH and insulin to promote normal carbohydrate and lipid metabolism.
Natural history of HIV-1 cell-free viremia
Authors: D. R. Henrard
Journal: JAMA (1995)

<h3>Objective.</h3> —To characterize the natural history of viremia with human immunodeficiency virus type 1 (HIV-1) and its association with disease progression from infection to acquired immunodeficiency syndrome (AIDS). <h3>Design.</h3> —Prospective cohort study. Annual specimens were tested for quantitative virion-associated HIV-1 RNA, p24 antigen, and CD4<sup>+</sup>lymphocyte levels. <h3>Participants.</h3> —A total of 42 homosexual men who seroconverted to HIV-1 between 1982 and 1985. <h3>Main Outcome Measures.</h3> —Trends over time in serum HIV-1 RNA level, correlations between serum HIV-1 RNA and other markers, and prediction of AIDS using these markers. <h3>Results.</h3> —HIV-1 RNA levels were stable overtime, increasing by 10-fold or more in only six (14%) of the 42 subjects during 3 to 11 years of follow-up. Mean HIV-1 RNA levels were 10<sup>3.8</sup>copies/mL if AIDS occurred in less than 4 years, 10<sup>3.07</sup>copies/mL if AIDS developed within 4 through 9 years, and 10<sup>2.27</sup>copies/mL if AIDS did not develop within 6 through 11 years. In both univariate and multivariate models, initial and subsequent HIV-1 RNA levels, p24 antigenemia, and percentage of CD4<sup>+</sup>lymphocytes were independently predictive of AIDS. <h3>Conclusions.</h3> —The stability of virion-associated HIV-1 RNA levels suggests that an equilibrium between HIV-1 replication rate and efficacy of immunologic response is established shortly after infection and persists throughout the asymptomatic period of the disease. Thus, defective immunologic control of HIV-1 infection may be as important as the viral replication rate for determining AIDS-free survival. Because individual steady-state levels of viremia were established soon after infection, HIV-1 RNA levels may be useful markers for predicting clinical outcome. (<i>JAMA</i>. 1995;274:554-558)
Serum type III procollagen aminopeptide for assessing liver damage in methotrexate-treated psoriatic patients
Authors: M.J. BOFFA, A. SMITH, R.J.G. CHALMERS, D.M. MITCHELL, B. ROWAN, T.W. WARNES, M. SHOMAF, N.Y. HABOUBI
Journal: British Journal of Dermatology (1996)
THE PLAGUE AND THE DOCTORS.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Inventory
Authors: Rae Varcoe
Journal: Annals of Internal Medicine (2001)

Ad Libitum4 December 2001InventoryRae Varcoe, MA, MB, ChB, FRACP, FRCPARae Varcoe, MA, MB, ChB, FRACP, FRCPAAuckland Hospital, Auckland 1, New ZealandSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-135-11-200112040-00006 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail this is my bedthese are my sheetshere is my clockon unsteady lockermy pillow fixes my scalprestraining myfears from flightmy thoughts turn inin the locker are my booksmy hands, too weakto hold them nowhold instead, your handthe morphine comesbetween me and thoughtbetween me and painbetween you and methe nurses do not sayhow long, or whenthe god who might say whyhas long since gonethis is my bedthis is my bodythis is my lifethese are my letters Author, Article, and Disclosure InformationAffiliations: Auckland Hospital, Auckland 1, New ZealandCorresponding Author: Rae Varcoe, MA, MB, ChB, FRACP, FRCPA, Auckland Hospital, Park Road, Private Bag 92024, Auckland 1, New Zealand. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 4 December 2001Volume 135, Issue 11Page: 953KeywordsFearMorphine ePublished: 4 December 2001 Issue Published: 4 December 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Back Cover: Cover Image, Volume 39, Issue 2
Authors: Kornelia J. Skowron, Thomas E. Speltz, Terry W. Moore
Journal: Medicinal Research Reviews (2019)

On the cover: The cover image is based on the Minireview Recent structural advances in constrained helical peptides by Kornelia J. Skowron et al., https://doi.org/10.1002/med.21540.
Prednisolone Phosphate in Rheumatoid Arthritis
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Grade Made in Examination
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Malaria Infection.
Authors: J. Wellington Byers
Journal: JAMA (1898)

Charlotte, N. C., March 7, 1898. <h3>To the Editor:</h3> —In your remarks under the above heading, in the issue of March 5, 1898 (page 561), you make some statements which appear to deserve some qualification, at least from my information and experience on the subject. That there is a form of malaria (the disease) which resists the. therapeutic action of quinin even when in proper dosage by the stomach, rectum and skin, is within the experience of a number of physicians throughout the South. This form of malaria, designated the estivo-autumnal, will not infrequently persist in spite of the exhibition of large and repeated doses of quinin, the patient dying literally saturated with the drug and thoroughly cinchonized. Dr. Osler, the highly gifted and capable authority quoted to support the points of the editorial, has given absolute testimony to the fact that quinin<i>will not</i>remove the crescentic forms from
THE REPAIR OF SCLERAL WOUNDS (INCLUDING RUPTURE) NEAR THE LIMBUS
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medical Genetics
Authors: David R. Cox
Journal: JAMA (1992)

A number of significant advances in medical genetics over the past year have been a result of early successes of the Human Genome Project, an international effort to construct a map of the human "genetic blueprint." An important goal of the Human Genome Project, which officially began in 1990, is to provide more efficient and cost-effective approaches for identifying human disease genes. However, identification of single genes that play key roles in human disease is a daunting task, given that there are an estimated 100 000 human genes scattered throughout the 3 billion base pairs of DNA that make up the human chromosomes. Over the past year, improvements in the map of the human genome have led to the chromosomal localization of a number of new disease genes,<sup>1</sup>including genes involved in breast cancer,<sup>2</sup>amyotrophic lateral sclerosis,<sup>3</sup>and diabetes.<sup>4</sup>In addition, advances in technologies that allow
PROTEIN HYPERSENSITIVENESS AND THE KIDNEYS
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medical licensure statistics for 1967
Authors: C. H. William Ruhe
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Management of Ventricular Tachyarrhythmias
Authors: Masood Akhtar
Journal: JAMA (1982)

IN A previous issue ofThe Journal(1982;247:671-674), the role of drug therapy in the control of ventricular tachyarrhythmias was explored. The discussion of this therapeutic approach continues, and two other broad categories of management, "pacing" and "surgery," are examined. <h3>Drug Therapy</h3><h3>Role of Electrophysiological Studies and Serial Drug Testing.—</h3> In recent years, electrophysiological studies have been used in an attempt to achieve a more objective therapeutic end point for the control of ventricular tachyarrhythmias.<sup>1</sup>This has been made possible by the realization that ventricular tachyarrhythmias can be induced by programmed electrical stimulation (PES) in the controlled environments of the electrophysiology laboratory. This is particularly true of ventricular tachycardia (VT) and ventricular fibrillation (VF), both of which are generally reentrant in nature and, therefore, inducible with PES in a majority of patients who have experienced VT or VF or both. Programmed electrical stimulation is accomplished through electrode catheters (similar
Gastrointestinal Bleeding
Authors: A. M. Kassem
Journal: Endoscopy (2004)

Studies on the endoscopic management of gastrointestinal bleeding are concentrating mainly on either evaluating already established techniques, with assessment of outcome - for example, band ligation and argon plasma coagulation - or on refining more recently introduced methods such as hemoclipping, or on exploring newer indications for known techniques, as with endoscopic ultrasonography. Of course, new devices to bridge diagnostic and therapeutic gaps in the field of gastrointestinal hemorrhage are also being introduced and subjected to preliminary trials - for example, the development of double-balloon enteroscopy and rotatable planar electrodes using radiofrequency for hemostasis. Continuing enthusiasm regarding capsule endoscopy is reflected by the large number of abstracts on this topic, as well as increasing interest in the study of small-bowel vascular lesions.
Expression of intercellular adhesion molecule 1 in human hepatocellular carcinoma
Authors: S MOMOSAKI
Journal: Hepatology (1995)

We investigated the expression of intercellular adhesion molecule 1 (ICAM-1) in ex vivo human hepatocellular carcinoma (HCC) cells and in vitro in eight liver cancer cell lines, including six HCC cell lines and two combined hepatocholangiocarcinoma (CHC) cell lines. Immunohistochemistry showed the expression of ICAM-1 on the HCC cell surface with honeycomblike appearance in most cases (96.2%). On the other hand, hepatocytes in noncancerous areas did not express ICAM-1, except those hepatocytes in the periportal and intra-acinar areas with inflammation. Immunohistochemical study on cultured cells revealed that four cultured HCC cell lines and one CHC cell line constitutively expressed ICAM-1 on the cell surface and in the cytoplasm. Flow cytometric analysis revealed that immunostain-positive cells expressed surface ICAM-1 with more than a 90% positive cell rate, and their expressions were upregulated by incubation of cells with inflammatory cytokines, such as interferon alfa, interferon gamma, tumor necrosis factor-α, and interleukin 1β. Soluble ICAM-1 was detected in supernatants of cell lines expressing cell surface ICAM-1, in addition to one HCC cell line without surface ICAM-1 expression, and was increased in amounts 2- to 20-fold by inflammatory cytokines. These findings suggest that liver cancer cells in ex vivo may express not only surface but also a soluble form of ICAM-1, differently from normal hepatocytes, and that both expressions are upregulated by inflammatory cytokines. (Hepatology 1995; 22:1708-1713).