Endotoxin Shock
Authors: WESLEY W. SPINK
Journal: Annals of Internal Medicine (1962)

Article1 October 1962Endotoxin ShockWESLEY W. SPINK, M.D., F.A.C.P.WESLEY W. SPINK, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-57-4-538 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince world war II extensive investigations on shock have been carried out. Within the past 5 years the subject has been thoroughly reviewed in 3 symposia (1-3). These discussions have emphasized the complexity of the problem and the necessity for more precise information on the nature of shock in the human being.Although hypotension is a cardinal sign in the early stages of shock, a more fundamental concept is necessary in defining the condition. Shock is the inadequate perfusion of tissues and organs with oxygenated blood resulting in hemodynamic changes and metabolic alterations that may be irreversible. Shock can be...References1. 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Author, Article, and Disclosure InformationAffiliations: Minneapolis, MinnesotaFrom the Department of Medicine, University of Minnesota Hospital and Medical School, Minneapolis, Minnesota.Supported by grant E4415 from the National Institutes of Health, United States Public Health Service.Presented at the Forty-third Annual Session of The American College of Physicians, Philadelphia, Pennsylvania, April 9-13, 1962.Requests for reprints should be addressed to Wesley W. Spink, M.D., Department of Medicine, University of Minnesota Medical School, Minneapolis 14, Minnesota. 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