tbuckley/cabot-search huggingface dataset:
Annual Report of the Supervising Surgeon-General of the Marine Hospital Service of The United States, for the Fiscal Year 1883.
Journal: JAMA (1883)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BONE ATROPHY FROM DISUSE
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical Immunology
Authors: Dennis A. Carson
Journal: JAMA (1977)

In the second edition of this excellent textbook, Drs Freedman and Gold, in collaboration with 12 other members of the division of clinical immunology at Montreal General Hospital, attempt to summarize in a single volume recent advances in basic immunology and their application to the diagnosis and treatment of human disease. Although the allergic, connective tissue, and immunodeficiency diseases are treated in greatest detail, the book is geared to the practicing physician, without regard to subspecialty. Individual chapters cover the immunologic aspects of infectious diseases, dermatology, nephrology, hematology, and endocrinology. Unfortunately, few photographs or figures illustrate the clinical syndromes described in the text. The references, although well selected, are far from complete. Of special interest is the thorough treatment of recent advances in tumor immunology and organ transplantation. The section on the clinical pharmacology of immunotherapy and immunosuppression is well organized and up to date. Immunology as applied to medicine
Unknown
Authors: Helen Montague Foster
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diabetic Retinopathy
Authors: Myron Yanoff
Journal: New England Journal of Medicine (1966)

THE frequency of vascular disease is known to increase directly with the duration of diabetes mellitus.1 , 2 Becently, electron-microscope studies have shown that capillaries in many of the diabetic patients' organ systems (fat being the notable exception) demonstrate basement-membrane thickening.3 4 5 6 7 8 9 10 Benal biopsy has revealed glomerular basement-membrane thickening quite early in the course of diabetes — that is, with minimal abnormalities of carbohydrate metabolism.8 Diabetic microangiopathy is the term that encompasses all the capillary changes in the diabetic patient.5 , 6 The specific dia- betic renal vascular (glomerular) lesions — that is, nodular and diffuse glomemlosclerosis — correlate well not only with the duration . . .
ALTERATIONS OF BRAIN VOLUME AND BLOOD VOLUME
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 428: Interventions Targeting Mitochondrial Function as Therapies to Reverse Cardiac Aging
Authors: Ying Ann Chiao, Ying Sonia Ting, Ellen Quarles, Gabriel Otero, Matthew Campbell, Yongping Yue, Dongsheng Duan, David Marcinek, Hazel H Szeto, Michael MacCoss, Peter S Rabinovitch
Journal: Circulation Research (2017)

Aging is associated with a higher incidence of cardiovascular disease and a significant decline in cardiac function. In individuals without overt cardiovascular disease, aging results in impaired diastolic function, reduced myocardial performance and increased prevalence of cardiac hypertrophy. Our laboratory has previously shown that transgenic mice expressing mitochondrial catalase (mCAT) have reduced mitochondrial oxidative damage and display delayed cardiac aging. This study aims to determine whether short-term treatments targeting mitochondrial function can reverse cardiac aging in old mice. The mitochondrial protective SS-31 peptide (elamipretide) has previously been shown to provide similar protection as mCAT in models of pressure overload-induced cardiac hypertrophy and failure. SS-31 binds to cardiolipin and improves the electron carrying function of cyt c , while reducing its peroxidase activity. We administered SS-31 to 24-month-old mice via osmotic minipump for 8 weeks, and found it to reduce cardiac hypertrophy and improve diastolic function and myocardial performance. SS-31 treatment attenuated the age-related increase in cyt c oxidation at Met-80, which has been associated with the disruption of Fe-S bond and activation of peroxidase activity of cyt c . SS-31 treatment also improved mitochondrial ultrastructure and induced AMPK activation in old hearts. To investigate whether SS-31 and mCAT protect cardiac aging by overlapping mechanisms, we administered SS-31 to old mCAT mice to study the effects of combined treatments. We found that SS-31 treatment cannot further improve the cardiac function of old mCAT mice. Concordantly, proteomic analysis revealed that changes in the cardiac proteome induced by SS-31 were partially overlapping with changes mediated by mCAT expression, particularly in the mitochondrial proteome, suggesting a convergence of molecular mechanisms of these two treatments. In addition, we showed that mCAT expression transduced by AAV9 in late-life also improved diastolic function, supporting the similar therapeutic effects of short-term mCAT and SS-31. In summary, these results support the therapeutic potential of mitochondrial-targeted interventions to reverse the effects of cardiac aging.
Guidelines for management of patients with psoriasis. Workshop of the Research Unit of the Royal College of Physicians of London; Department of Dermatology, University of Glasgow; British Association of Dermatologists.
Authors: Richard Williams
Journal: BMJ (1991)

Psoriasis affects 1-2% of the population of the United Kingdom.'The degree of psychological and social morbidity that accompanies psoriasis is commonly underestimated by the medical profession2 and this can result in less than optimal care.After an initiative by the research unit of the Royal College of Physicians of London and the dermatology department of the University of Glasgow, which was subsequently endorsed by the British Association of Dermatologists, a group of dermatologists met to produce guidelines for managing patients with psoriasis.These guidelines are aimed at everyone who is concerned in the manage- ment of patients with psoriasis, and their purpose is to promote a high standard of continuing care.
PATHOGENESIS OF ACUTE RENAL FAILURE FOLLOWING INJURY
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Epidemiological Survey of Cholesterolemia and Its Significance
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
National Cancer Institute Monograph No. 12
Journal: JNCI Journal of the National Cancer Institute (1963)

Journal Article National Cancer Institute Monograph No. 12 Get access JNCI: Journal of the National Cancer Institute, Volume 31, Issue 4, October 1963, Page 1037, https://doi.org/10.1093/jnci/31.4.1037 Published: 01 October 1963
Phenothiazine-induced T-wave abnormalities. Effects of overnight fasting
Authors: S. C. Alvarez-Mena
Journal: JAMA (1973)

Effects of overnight fasting and potassium salts given orally (10 gm) on phenothiazine-induced repolarization abnormalities were evaluated in 100 psychiatric patients. Overnight fasting resulted in complete normalization of the electrocardiograms of 57 patients, while the remainder were corrected by potassium administration. The mean serum potassium level was significantly higher for the group that normalized with fasting alone. These results are explainable by a combined phenothiazine- and glucose-induced increase in the intracellular-extracellular ratio of potassium, an important factor in the genesis of repolarization abnormalities.
&lt;TITLE&gt;Autistic Disorder&lt;/TITLE&gt;
Journal: JAMA (2001)

is a public service of JAMA.The information and recommendations appearing on this page are appropriate in most instances, but they are not a substitute for medical diagnosis.For specific information concerning your personal medical condition, JAMA and the AMA suggest that you consult your physician.This page may be reproduced noncommercially by physicians and other health care professionals to share with patients.Any other reproduction is subject to AMA approval.
December 2, 1998
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Characterization of soybean allergens causing sensitization of occupationally exposed bakers
Authors: X. Baur, M. Pau, A. Czuppon, G. Fruhmann
Journal: Allergy (1996)

Fourteen bakers suffering from workplace-related respiratory symptoms and sensitized to soybean were studied. Twelve of them were also allergic to wheat flour, 10 to rye flour, and five to α-amylase of Aspergillus oryzae (Asp o 2). IgE estimation by RAST strongly indicated that the trypsin inhibitor and lipoxidase are major allergens of soybean. Various allergenic components could be characterized by immunoblotting after two-dimensional electrophoresis. Our RAST and immunoblotting results show an interindividually different allergic response to inhalative soybean constituents, and that the trypsin inhibitor (20 kDa, pI˜4.5) is an important inhalative soybean allergen recognized by IgE antibodies in the sera of 86% of the examined sensitized bakers.
Cytarabine for herpesvirus infections
Authors: W. Hryniuk
Journal: JAMA (1972)

The antileukemic agent cytarabine has recently been used to treat herpesvirus infections, but the regimens advocated for this purpose are high-dose prolonged infusions (100 mg/sq m of body surface per day for five days). The use of cytarabine as an antiviral agent has been restricted by the toxic effects produced with these regimens. We have treated ten patients with herpesvirus infections of wide range of severity using cytarabine infusions ranging from 10 to 100 mg/sq m /day for 1 1/2 to 7 days. In each case, the viral infection responded favorably soon after cytarabine therapy was started, even when low doses were given for short periods. The low-dose short-period infusions produced few toxic effects. Thus, cytarabine may be more useful as an antiviral agent than has previously been realized. Controlled studies are required to confirm this clinical impression.
Transient tyrosinemia in full-term infants
Authors: H. L. Levy
Journal: JAMA (1969)

Transient tyrosinemia has been found in approximately 1.8% of all infants in Massachusetts tested within the first 6 weeks of life (2,085 infants out of a total screened population of 117,752). About 24% have been full-term by weight and gestational criteria. In general, infants with lower birth weights had more marked tyrosinemia. However, several babies with average or above average birth weights had blood tyrosine concentrations of 10 mg/100 ml to more than 20 mg/100 ml, and in a few of these latter infants the tyrosinemia lasted as long as 9 to 13 weeks after birth. The infants have been clinically well.
Protecting the Uninsured
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Uses and abuses of psychiatric consultation
Authors: J. J. Schwab
Journal: JAMA (1968)

The psychiatric consultation is used for diagnosing and treating patients, for education, and for clarification of staff problems. The referring physician abuses the consultation when he (1) does not make explicit the reason for referral, (2) uses referral as a last-resort measure, (3) ignores the nurse's role, (4) fails to refer some dying patients, (5) is inconsistent in referring patients with personality disorders, or (6) misdiagnoses organic brain syndromes. The psychiatrist abuses the consultation by (1) delaying his response, (2) not obtaining a comprehensive view of the patient—failing to review the medical record, (3) writing a lengthy consultation note filled with jargon, (4) "taking over" the referring physician's patient, or (5) not using the consultation for teaching and learning. Correct use requires proper timing, understanding the psychosocial background, and implementing recommendations for continuing care.
Middle and Inferior Temporal Gyrus Gray Matter Volume Abnormalities in First-Episode Schizophrenia: An MRI Study
Authors: Noriomi Kuroki
Journal: American Journal of Psychiatry (2006)

Objective: Magnetic resonance imaging (MRI) studies of schizophrenia reveal temporal lobe structural brain abnormalities in the superior temporal gyrus and the amygdala-hippocampal complex. However, the middle and inferior temporal gyri have received little investigation, especially in first-episode schizophrenia. Method: High-spatial-resolution MRI was used to measure gray matter volume in the inferior, middle, and superior temporal gyri in 20 patients with first-episode schizophrenia, 20 patients with first-episode affective psychosis, and 23 healthy comparison subjects. Results: Gray matter volume in the middle temporal gyrus was smaller bilaterally in patients with first-episode schizophrenia than in comparison subjects and in patients with first-episode affective psychosis. Posterior gray matter volume in the inferior temporal gyrus was smaller bilaterally in both patient groups than in comparison subjects. Among the superior, middle, and inferior temporal gyri, the left posterior superior temporal gyrus gray matter in the schizophrenia group had the smallest volume, the greatest percentage difference, and the largest effect size in comparisons with healthy comparison subjects and with affective psychosis patients. Conclusions: Smaller gray matter volumes in the left and right middle temporal gyri and left posterior superior temporal gyrus were present in schizophrenia but not in affective psychosis at first hospitalization. In contrast, smaller bilateral posterior inferior temporal gyrus gray matter volume is present in both schizophrenia and affective psychosis at first hospitalization. These findings suggest that smaller gray matter volumes in the dorsal temporal lobe (superior and middle temporal gyri) may be specific to schizophrenia, whereas smaller posterior inferior temporal gyrus gray matter volumes may be related to pathology common to both schizophrenia and affective psychosis.