tbuckley/cabot-search huggingface dataset:
IT-23 * INDUCTION OF ROBUST TYPE-1 CD8+ T-CELL RESPONSES IN WHO GRADE II LOW-GRADE GLIOMA PATIENTS RECEIVING PEPTIDE-BASED VACCINES IN COMBINATION WITH POLY-ICLC
Authors: H. Okada, L. Butterfield, R. Hamilton, B. Ahn, G. Kohanbash, J. Drappatz, J. Engh, N. Amankulor, M. Lively, M. Chan, A. Salazar, E. Shaw, D. Potter, F. Lieberman
Journal: Neuro-Oncology (2014)

PURPOSE: WHO grade II low-grade gliomas (LGGs) with high risk factors for recurrence are mostly lethal despite current treatments. We conducted a phase I study to evaluate the safety and immunogenicity of subcutaneous vaccinations with synthetic peptides for glioma-associated antigen (GAA) epitopes in HLA-A2+ adults with high-risk LGGs in the following three cohorts: 1) patients without prior progression, chemotherapy or radiation therapy (RT); 2) patients without prior progression or chemotherapy but with prior RT, and 3) recurrent patients. METHODS: GAAs were IL-13Rα2, EphA2, WT1, and Survivin. Synthetic peptides were emulsified in Montanide-ISA-51 and given every 3 weeks for 8 courses with intramuscular injections of poly-ICLC, followed by q12week booster vaccines. RESULTS: Cohorts 1, 2, and 3 enrolled 12, 1, and 10 patients, respectively. No regimen-limiting toxicity was encountered except for one case with Grade 3 fever, fatigue and mood disturbance (Cohort 1). ELISPOT assays demonstrated robust IFN-γ responses against at least 3 of the 4 GAA epitopes in 10 and 4 cases of Cohorts 1 and 3, respectively. Cohort 1 patients demonstrated significantly higher IFN-γ responses than Cohort 3 patients. Median progression-free survival (PFS) periods since the 1st vaccine are 17 months in Cohort 1 (range 10-42+) and 12 months in Cohort 3 (range 3-37+). The only patient with large astrocytoma in Cohort 2 has been progression-free for over 60 months since diagnosis. CONCLUSION: The current regimen is well tolerated and induces robust GAA-specific responses in WHO grade II glioma patients. These results warrant further evaluations of this approach.
Dementia
Authors: D. C. Costa
Journal: Clinical Nuclear Medicine (1998)

The term dementia is often used to describe chronic, irreversible and progressive development of multiple cognitive deficits that include memory impairment (Criterion A1) and at least one of the following other cognitive abnormalities (Criterion A2): aphasia, apraxia, agnosia, or a disturbance in executive functioning [1, 2]. These cognitive deficits must be severe enough to produce impairment in occupational or social functioning (Criterion B) and there must be a clear-cut decline from previously higher levels of functional capacity. The nature and degree of impairment are variable and often influenced by the social setting and sometimes also by the cultural environment. Approximately one-third of patients initially presenting with dementia have reversible syndromes at their final diagnosis [3].
Association of PAH-DNA Adducts in Peripheral White Blood Cells with Dietary Exposure to Polyaromatic Hydrocarbons
Authors: Nathaniel Rothman, Miriam C. Poirier, Robert A. Haas, Adolfo Correa-Villasenor, Patrick Ford, John A. Hansen, Tara O'Toole, Paul T. Strickland
Journal: Environmental Health Perspectives (1993)

Previous investigations suggest that dietary sources of polycyclic aromatic hydrocarbons (PAHs) contribute to the PAH-DNA adduct load in peripheral white blood cells (WBCs). In the current study, we measured PAH-DNA adducts by enzyme-linked immunosorbent assay in WBCs obtained from 47 California wildland (forest) firefighters at two time points (early and late) during an active forest fire season. PAH-DNA adduct levels were not associated with recent firefighting activity, but were positively associated with frequency of charbroiled food consumption in the previous 2 weeks. In addition, adduct levels declined with time since last ingestion of charbroiled food. These studies indicate that recent consumption of charbroiled food contributes to the PAH-DNA adduct load in peripheral WBCs.
Some Rum and Odd Arthropathies
Authors: W Katz, G Ehrlich
Journal: Annals of the Rheumatic Diseases (1969)

For more than 60 years the mainstream of investigation into the pathogenesis of gout centred in the mechanism of hyperuricaemia while recently urate crystal-induced arthritis had rekindled interest.Little attention, however, had been drawn to the deposition of these urate crystals in body tissues.It was the purpose of this experimentation to substantiate at a biochemical level heretofore anatomical observations of the predilection of urate crystals to deposit in the connective tissues such as cartilage and synovia.To this end it was demonstrated that an important ground substance com- ponent, PPL, a protein-polysaccharide containing chondroitin sulphate, was capable of augmenting urate solubility and inhibiting urate crystallization at 4°C.A similar substance had been identified in the sera of both normal subjects and those with gout.It travelled electrophoretically with the alpha and beta globulins and was primarily responsible for the ability of serum to hold more urate in solution than buffers of identical molarity and hydrogen ion concentration.Alteration of the urate-bound PPL molecule resulted in precipitation of urate crystals in a manner proposed to occur in vivo.Utilizing this material, a schema was evolved which provided a new concept for the development of gout in man.Discussion.-DR.J. T. Scorr (London) asked if this hypothesis explained the predilection of urates to deposit in the great toe.DR. KATZ felt that it would be interesting to analyse the nature of the polysaccharide in cartilage from various sites.
DEATH OF THE EDITOR OF THE LANCET.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
JAMA 75 YEARS AGO
Journal: JAMA (1981)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MYASTHENIA GRAVIS.
Authors: C. EUGENE RIGGS
Journal: JAMA (1906)

It is clear to me that early in this case there was an abscess between the vertebra and the anterior wall of the pharynx.The suddenness of the formation, the violence of the onset, the absence of any premonitory trouble, and the abrupt and complete palsy of the pharyngeal mus- cles which seize on and deliver the bolus to the still active esophagus are all remarkable and difficult to ex- plain.The date of the origin of the tumor is doubt- ful.It was too dense to have been of rapid growth.It could hardly have escaped Dr. Mackenzie, and was probably of a gradual and later formation; nor can it be used to explain the paralysis.There was no sufficient evidence of diphtheria, and had there been it could not explain the paralysis, which is never an initial phenomenon of diphtheria.The early advent, the completeness and the changeless permanence of the palsy enable us to dismiss this malady as the cause.We must of need fall back on some toxic cause as the parent of the local palsy, but whether this fell directly on the postpharyngeal plexus or, through the sequent abscess, damaged it I am unable to decide.Nor can I explain why this dense growth arose, as seems likely, from the site of the abscess.The great soreness of the muscles elsewhere and the inflammation of the wrist add to the probabilities of an acute toxic cause, primarily local.The alarming sense of loss of power to swallow must have told emotionally even on a woman as enduring and full of patient courage.Whether this alone or the toxic blow may account for her hysterical symptoms, ptosis, analgesia, retarded sensation, I can not say.I have seen few cases in which the problems presented were more difficult of solution.No treatment was of value in the local disorder, but it was plain that the last year of care as to the nature and amount of diet had resulted in some increase of sen- sibility in the throat, but in no gain of power to swallow food.Only one therapeutic means seemed to be of any value.A skilful masseuse was able to use friction of the growth for a few minutes twice a day.This resulted in slowly increasing sensibility of the parts, but in no other change.An operation was, of course, considered, but not only had we doubts as to its competence to insure re- turn of power, but it involved difficulties of a nature to cause the most daring surgeon to hesitate.
Abstract B1-13: Phospho-proteomic analysis of MEK inhibition in mutant NRAS melanoma
Authors: Ha Linh Vu, Michael A. Davies, Andrew E. Aplin
Journal: Cancer Research (2015)

Abstract Melanoma is a devastating form of skin cancer with limited therapeutic options. Fifteen to twenty percent of melanoma patients have an activating mutation in NRAS, a small GTPase. NRAS has several downstream effectors, the most well-characterized is RAF leading to activation of MEK/ERK. While there are no FDA-approved targeted therapies for melanoma patients with a primary mutation in NRAS, one form of targeted therapy that has been explored is MEK inhibition. Phase I to III studies of MEK inhibitors in mutant NRAS melanomas have shown disappointing clinical efficacy, the reasons for which are unclear. In 3D systems that mimic the dermal microenvironment, we found a heterogeneous response in our panel of mutant NRAS melanoma cells to the allosteric MEK inhibitor, trametinib. To explore the underlying basis of this heterogeneity, we utilized a high-throughput reverse-phase protein array (RPPA) platform to identify compensatory signaling alterations. The RPPA analysis of phospho-proteomic changes in NRAS mutant melanoma in response to trametinib indicated a compensatory increase in AKT signaling. Interestingly, we detected a decrease in mitogen inducible gene 6 (MIG6), a negative regulator of ERBB receptors. The overexpression of MIG6 led to a negative regulation of EGFR (ERBB1) and ERBB2, and subsequent decrease in AKT activation. Conversely, the depletion of MIG6 increased EGFR and ERBB2 signaling. Either depletion of MIG6 or addition of EGF increased migration of NRAS mutant cells treated with trametinib, an invasive phenotype that may mitigate the negative effects of trametinib on cell growth. Our results indicate a potential role for the combined inhibition of EGF/ERBB receptors and MEK in NRAS mutant melanoma patients. Citation Format: Ha Linh Vu, Michael A. Davies, Andrew E. Aplin. Phospho-proteomic analysis of MEK inhibition in mutant NRAS melanoma. [abstract]. In: Proceedings of the AACR Special Conference on Computational and Systems Biology of Cancer; Feb 8-11 2015; San Francisco, CA. Philadelphia (PA): AACR; Cancer Res 2015;75(22 Suppl 2):Abstract nr B1-13.
Clinical and Cosmetic Results in Squamous Cancer of the Lip Treated by 140 Kv Radiation Therapy
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Highlights
Journal: JAMA (2015)

NSAIDs, Antithrombotic Therapy After Myocardial Infarction 805Use of nonsteroidal anti-inflammatory drugs (NSAIDs) is discouraged after myocardial infarction; however, use of NSAIDs is widespread.In an analysis of Danish health and mortality administrative registries, Olsen and colleagues examined the association of NSAID use with risk of bleeding and cardiovascular events in 61 971 patients with incident myocardial infarction.The authors found that among patients receiving antithrombotic therapy after myocardial infarction, concomitant use of NSAIDs was associated with increased risk of bleeding and excess thrombotic events during a median follow-up of 3.5 years.In an Editorial, Campbell and Moliterno discuss hazards of adding NSAIDs to antithrombotic therapy after myocardial infarction.
Pseudoxanthoma Elasticum and Mitral-Valve Prolapse
Authors: Mark G. Lebwohl, Douglas Distefano, Philip G. Prioleau, Martin Uram, Lawrence A. Yannuzzi, Raul Fleischmajer
Journal: New England Journal of Medicine (1982)

PSEUDOXANTHOMA elasticum is an inherited disorder of connective tissue, with cutaneous, ophthalmologic, and systemic manifestations. The disease has an estimated prevalence of one in 160,000.1 Various modes of inheritance have been demonstrated, including two autosomal dominant types and two autosomal recessive types.2 The pathogenesis of the disorder is controversial; most investigators attribute the disease to a basic defect in elastic tissue, although others have supported an older theory involving collagen degeneration.The most characteristic clinical manifestations are yellowish, grouped papules and plaques on the skin of flexural areas, which may result in redundant skin folds (Fig. 1). Other findings include . . .
CORRECTIONS
Journal: Journal of Clinical Investigation (1979)

Before the control study, 1.87 g of Na2HPO4 was added to the diet each day.TO READ Before the control study, 1.87 g of phosphorus as Na HPO was added to the diet each day.Page 1241, Methods, 2nd paragraph, 8th sentence: CHANGE For the control study, sufficient diet was fed to provide 30 calories/kg per day.TO READ For the control study, 20 glkg per day of the diet was fed to the animals.
Transplantation
Authors: Paul S. Russell, Henry J. Winn
Journal: New England Journal of Medicine (1970)

Clinical Organ TransplantationA number of the tissues and organs of the human body have now been transferred in planned attempts to compensate for life-threatening functional deficits. Already the list of conditions treated includes developmental defects, neoplasms confined to a single organ, the effects of trauma, "degenerative" diseases (for example, myoeardial infarction) and certain infectious diseases and their complications (such as glomerulonephritis or hepatitis). Although there are many similarities in the biologic problems encountered with transplantation of each organ, each will be dealt with separately for convenience.KidneyThere has been much more experience with transplantation of the kidney than . . .
Current Status of Immunological Adjuvants
Authors: H S Warren,, F R Vogel, and, L A Chedid
Journal: Annual Review of Immunology (1986)

Exhausted CD8 T (Tex) cells are a distinct cell lineage that arise during chronic infections and cancers in animal models and humans. Tex cells are characterized by progressive loss of effector functions, high and sustained inhibitory receptor expression, ...Read More
Physiology
Authors: Hebbel E. Hoff, H. J. Scott
Journal: New England Journal of Medicine (1948)

ON NOVEMBER 22, 1947, the British Medical Journal 1 2 3 4 celebrated with a special issue the ninetieth birthday of Sir Charles Sherrington, whose Integrative Action of the Nervous System had been reprinted earlier in the summer as a feature of the seventeenth International Physiological Congress, the first to be held since the end of the war.5 Both were gracious tributes to one of the great philosophers of the nervous system, a worthy member of that long and unbroken descent of scientific greatness represented by presidents of the Royal Society. Like that of Boyle, one of the founders of the Society, his philosophy . . .
Management of major surgical blood loss without transfusion
Authors: S. Gollub
Journal: JAMA (1966)

Six patients of the Jehovah's Witness faith underwent open-heart surgery without receiving blood at any time. Marked acute decreases in red blood cell mass and low absolute levels of hematocrit followed exclusive use of crystalloid solutions for priming the extracorporeal apparatus and to replace blood loss postoperatively. Sequential studies of renal, cerebral, cardiac, and hepatic function showed no significant impairment up to one week after surgery. There was one operative fatality. The other five patients were discharged ambulatory and improved. Maintenance of blood volume appeared to be a significant factor in prevention of morbidity and mortality.
Literature
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
DUODENAL FISTULA
Authors: JOHN J. GILBRIDE
Journal: JAMA (1930)

External duodenal fistula is a rare condition. Two forms of fistula have been described; namely, an external and an internal duodenal fistula. External duodenal fistula is more frequent than is internal fistula. Internal duodenal fistula may occur between the duodenum and other abdominal viscera, as, for example, between the duodenum and the gallbladder. A number of cases of so-called internal duodenal fistula have been reported in which there was a rupture of the duodenum. These cases of rupture of the duodenum, which are not true fistula, were caused by indirect violence inflicted on the abdomen, such as a kick from a horse, a fall, or a blow by being struck by a golf ball. External duodenal fistula is usually caused by injury to the duodenum during the performance of surgical operations in the right upper part of the abdomen. Injury to the duodenum may occur during operation on the duodenum,
SECRECY VERSUS LACK OF KNOWLEDGE IN MEDICINE
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal