tbuckley/cabot-search huggingface dataset:
Ochronosis from Quinacrine (Atabrine)
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Heterogeneity of procollagen types I and IV expressing liver cells in vivo Institute of Pathology1 and Department of Gastroenterology2, Klinikum Benjamin Franklin, Free University, Berlin, Germany; Department of Clinical Pathophysiology3, University of Florence, Florence, Italy; Department of Surgery4, Virchow-Klinikum, Humboldt-University, Berlin, Germany
Journal: Hepatology (1995)
Social mores influence lessons of science
Authors: T. Ziporyn
Journal: JAMA (1985)

"The miasmatic, contingent contagionist theorists of the Victorian public health reform were heavily influenced both by the state of medical science and social conditions. Social conditions continued to limit the impact of medical science on public health even after the first generation of reformers and the emergence of bacteriology." So stated Dale C. Smith, PhD, in a talk on "Eberth, Escherich, and Enteric Fever," given at this year's annual meeting of the American Association for the History of Medicine in Durham, NC. By examining the nature of medical science available to the medical practitioners and reformers of the late 19th century, Smith was not trying to glean practical medical information but was exploring the ways in which culture and technology influence medicine. Although the etiological agent of typhoid fever was discovered in 1880 and practitioners had a fairly complete knowledge of the pathology and epidemiology of the disease, typhoid continued
PARAMOUNT: Final overall survival (OS) results of the phase III study of maintenance pemetrexed (pem) plus best supportive care (BSC) versus placebo (plb) plus BSC immediately following induction treatment with pem plus cisplatin (cis) for advanced nonsquamous (NS) non-small cell lung cancer (NSCLC).
Authors: Luis Paz-Ares, Filippo De Marinis, Mircea Dediu, Michael Thomas, Jean-Louis Pujol, Paolo Bidoli, Oliver Molinier, Tarini Prasad Sahoo, Eckart Laack, Martin Reck, Jesus Corral Jaime, Symantha Melemed, William J. John, Nadia Chouaki, Annamaria Zimmermann, Carla Visseren-Grul, Cesare Gridelli
Journal: Journal of Clinical Oncology (2012)

LBA7507 Background: The PARAMOUNT trial showed that pem continuation maintenance therapy significantly reduced the risk of disease progression over plb (HR=0.62; 95% CI: 0.49-0.79; p &lt;0.0001) in patients (pts) with advanced NS NSCLC who had not progressed during pem-cis induction. Here we present the final OS data. Methods: In a double-blind, plb-controlled study, alpha-controlled for OS, 939 pts received induction (4 cycles of pem 500 mg/m 2 and cis 75 mg/m 2 on d1 of 21d cycles), and 539 pts who had not progressed and had an ECOG performance status (PS) of 0/1 were randomized (2:1) to maintenance pem (500 mg/m 2 , on day 1 of 21-day cycles) plus BSC or plb plus BSC until disease progression. All received B 12 , folic acid, and dexamethasone. After 397 deaths, a log-rank test compared OS between arms using anominal α level of 0.0498. Results: Pt characteristics were balanced between arms: median age 61 years; 58% men; 32% PS 0; 95% Caucasian; 86% adenocarcinoma; 45% complete/partial response (CR/PR) to induction. Pem resulted in a statistically significant 22% reduction in risk of death (HR=0.78). The HR was the same when measured from the beginning of induction. Survival improvement was similar for pts with an induction outcome of CR/PR versus stable disease. Conclusions: Pem continuation maintenance therapy offers superior OS compared with plb. These final results confirm that pem-cis induction followed by continuation pem further benefits pts compared with induction therapy alone, offering a change in the treatment paradigm for advanced NS NSCLC. [Table: see text]
INTERNATIONAL ABSTRACTS
Journal: JAMA (1983)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ablation of Key Oncogenic Pathways by RITA-Reactivated p53 Is Required for Efficient Apoptosis
Authors: Vera V. Grinkevich, Fedor Nikulenkov, Yao Shi, Martin Enge, Wenjie Bao, Alena Maljukova, Angela Gluch, Alexander Kel, Olle Sangfelt, Galina Selivanova
Journal: Cancer Cell (2017)
Bioastronautics
Authors: Eugene P. Cassidy
Journal: JAMA (1964)

The foreword states that the objective of man in space is not merely getting there, but to use his capabilities when he gets there. The present book develops the complexities involved, often giving the reader new insights. The heterogeneity of the articles is striking. There are 15 papers whose authors, according to the dust jacket, are "recognized experts in their fields." But one can safely conclude that the membership of several of these fields could hold a convention in an elevator. While several of the papers might better have been excluded, the majority are good, readable reviews. The problems of acceleration, vibration, noise, atmospheric requirements, and radiation are covered in the light of present knowledge. The interaction of men and machines and the training and physiological effects of space [ill]ght are also well detailed. The last part of the book consists of three essays on the outlook for the future.
Gonadal Dysfunction in Patients Treated for Metastatic Germ-Cell Tumors
Authors: Stuart P. Leitner, George J. Bosl, Daiva Bajorunas
Journal: Journal of Clinical Oncology (1987)

In the article by Leitner et al, "Gonadal Dysfunction in Patients Treated for Metastatic Germ Cell Tumors" (Journal of Clinical Oncology 4:1500–1505, 1986), an error was made in Table 3. The correct value for Testosterone under the heading "Treated Patients" is 581 ± 77 ng/dL.
Poison Centers Field Increasing Calls About e-Cigarette Exposure
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
NATURAL RACE IMMUNITY..
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Genetic-Environmental Interactions in Relation to Low Dose Studies: A Possible Model from Breast Cancer
Authors: Nicholas L. Petrakis
Journal: Environmental Health Perspectives (1981)

The identification of genetically susceptible individuals may permit the determination of genetic and environmental interactions which result in disease. This paper presents some recent findings on possible genetic-environmental interactions in breast disease as determined by a "nature-nurture" model employing epidemiological risk factors and cytologic studies of breast secretions obtained by nipple aspiration. The findings indicate that severe changes in the cytologic characteristics of the fluid are associated with a positive family history of breast cancer and clinical fibrocystic disease. These findings were interpreted as supporting the hypothesis that women with such a family history may have increased susceptibility to environmental factors. This model may have utility in other environmental epidemiologic studies.
Book Review Review of General Psychiatry Third edition. Edited by Howard H. Goldman. 495 pp. Norwalk, Conn., Appleton and Lange, 1992. $29.50. Massachusetts General Hospital Handbook or General Hospital Psychiatry Third edition. Edited by Ned H. Cassem. 662 pp. St. Louis, Mosby—Year Book, 1991. $37.95. Mania and Depression: A classification of syndrome and disease By George Winokur. 267 pp. Baltimore, Johns Hopkins University Press, 1991. $50. Somatization Disorder in the Medical Setting By G …
Authors: Lloyd A. Wells
Journal: New England Journal of Medicine (1992)
Charcot-Marie-Tooth disease. A diagnostic problem
Authors: I. M. Siegel
Journal: JAMA (1974)

IT HAS been suggested that the primary abnormality in muscular dystrophy lies not in the muscle but in the motor neuron on whose trophic factor the function and survival of muscle fibers depend.<sup>1</sup> This "neurogenic hypothesis"<sup>2</sup>might explain those confusing neuropathic electromyographic responses seen in some cases of myopathy, as well as perplexing elevations of serum muscle enzyme levels found in certain neuropathic states. Diagnosis, and thus prognosis, is confounded when a patient shows the features of both neuropathic and myopathic disease. The following examples illustrate this problem. <h3>Report of Cases</h3> Two brothers, aged 31 and 32 years, of Appalachian extraction, had similar complaints. The elder noted progressive weakness for seven years in his arms and legs. His birth and developmental history were normal. He was athletically active until the onset of symptoms. Two younger sisters were living and well. His two sons, aged 7 and 8 years, and
Alterations in messenger RNA encoding atrial natriuretic hormone receptor A and C subtypes during hepatic regeneration*1
Authors: T PATEL
Journal: Hepatology (1995)

Previously, we demonstrated that, 48 hours after partial hepatectomy, in the regenerating liver the number of both atrial natriuretic hormone (ANF) receptor subtypes, the guanylyl cyclase—linked and ANF-C receptors, is increased twofold. Subsequently, we demonstrated that activation of ANF-C receptors inhibits growth of hepatocytes. Therefore, studies were performed to determine whether, during hepatic regeneration, the increase in ANF receptor subtypes is accompanied by an increase in their respective transcripts. Our data demonstrate that in the normal and regenerating rat liver, the predominant guanylyl cyclase-linked ANF receptor is of the ANF-A subtype. Moreover, messenger RNA (mRNA) encoding the ANF-A and ANF-C receptors are transiently increased after surgery; the levels of mRNA encoding both receptor subtypes remain unchanged in livers of sham-operated animals. ANF-A receptor mRNA is maximally increased 12 hours after partial hepatectomy, whereas the maximal increase in ANF-C receptor mRNA is observed between 0.5 hour and 4 hours after hepatectomy. The increase in ANF-C receptor transcript is accompanied by increased expression of protein, 4 hours after hepatectomy. However, the ANF-C receptor protein is also elevated 48 hours after partial hepatectomy when ANF-C receptor mRNA levels are not different from controls. Likewise, although ANF-A receptors are increased when hepatic levels of mRNA encoding the protein are maximally elevated, the maximal increase in ANF-A receptor protein occurs at times when transcript levels are low and similar to those in sham-operated controls. These findings demonstrate differential regulation in the expression of ANF-A and ANF-C receptors and are illustrative of regulation of expression of both receptors at the translational or posttranslational levels.
NMR structure of phospho‐tyrosine signaling complexes
Authors: Carol Beth Post, Beverly S. Gaul, Elan Zohar Eisenmesser, Michael L. Schneider
Journal: Medicinal Research Reviews (1999)

A structural basis for activation and substrate specificity of src tyrosine kinases, and regulation of protein–protein association by tyrosine phosphorylation is described. Lyn, a src-family tyrosine kinase, recognizes and phosphorylates the immunoreceptor tyrosine-based activation motif, ITAM, a critical component in transmembrane signal transduction in hemopoietic cells. The structure of an ITAM peptide substrate bound to an active form of Lyn tyrosine kinase was determined by high-resolution NMR, and a model of the complex was generated using the crystallographic structure of Lck, a closely related Src-family kinase. The results provide a rationale for the conserved ITAM residues and specificity of Lyn, and suggest that substrate plays a role in stabilizing the kinase conformation optimal for catalysis. It is our hope that the Lck-ITAM peptide model complex will be useful in aiding structure-based drug design efforts that target substrate binding determinants in the design. Concerning the regulation of protein–protein association, we report on a complex between erythrocyte band 3 and two glycolytic enzymes, aldolase and glyceraldehyde-3-phosphate dehydrogenase. The formation of this complex is negatively regulated by tyrosine phosphorylation of band 3 by p72syk tyrosine kinase. In red blood cells, this association results in a decrease in glycolysis due to competitive inhibition of the glycolytic enzymes. The structure of band 3 recognized by the glycolytic enzymes was determined by solution NMR, and found to be a loop structure with tyrosine centrally positioned and excluded from intermolecular contact. This phosphorylation sensitive interaction, or PSI, loop may be the basis of a general mechanism for negative regulation through tyrosine phosphorylation. © 1999 John Wiley & Sons, Inc. Med Res Rev, 19, No. 4, 295–305, 1999.
Examination of the blood in the presence of venous thrombosis
Authors: M. Hume
Journal: JAMA (1967)

Seven tests were compared in blood samples collected from normal individuals and patients with venous thrombosis. Three tests were found to have significance for discrimination: platelet entrapment in glass spheres, the hematocrit, and partial thromboplastin time of dilute plasma. A good, but incomplete, separation of individuals was effected by using a discriminant function based on these three variables.
Primary lymphomas of the thyroid gland
Authors: D. K. Sirota
Journal: JAMA (1979)

Twelve patients with primary lymphoma of the thyroid gland were reviewed. Based on clinical observations of this group of patients and a review of the literature, a composite clinical picture can be drawn of the patient at high risk of having primary lymphoma of the thyroid gland. This condition should be considered in the differential diagnosis in patients with a history of lymphocytic thyroiditis and an enlarging neck mass, tender or nontender. The mass may be cold or cool with areas of patchy uptake shown on scintillation scanning. The patient has a greater than 50% chance of having hoarseness with or without vocal cord paralysis. We also review the pathogenesis and prognosis of primary lymphoma of the thyroid gland. (<i>JAMA</i>242:1743-1746, 1979)
Babywalkers.
Journal: BMJ (1988)

also by their total inabilitv to inform them of this communication gap, let alone to tune in on the same wavelength as the doctor.It was Isocrates who once said, "The proper use of language (speech) is the most substantial index of sound thinking."Is there no w.ay of comparing a minimum standard of expressive speech with a clinical test of oratorical competence?This is remarkable when one realises that it is necessary to pass the asessment of spoken English to become an American citizen.Our medical schools and univer- sities so obviously concentrate on the written word that it is difficult to convince them of their one eyed view.The aim of our modern education system is to achieve a competent standard of written composition culminating in that peak of eminent scholarship, the Civil Service memorandum, which everv bureaucrat can read and act on.Nowadays there is a great danger that doctors will retreat behind laboratory doors and treat patients only by automatic responses to programmed instructions.There is an astonishing vitality to speech which adds an extra dimension to the power of the spoken word to affect the listener for good or ill.It is this dynamic aspect of speech that chills the heart of every candidate and examiner in the viva voce.In my opinion the examiners of PLAB and the Royal College of General Practitioners are shirking their responsibility to patients.
MILITARY DERMATOLOGY
Authors: LEON H.  WARREN
Journal: Annals of Internal Medicine (1944)

Article1 March 1944MILITARY DERMATOLOGYLEON H. WARRENLEON H. WARRENSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-20-3-395 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMilitary dermatology differs from civilian dermatology in the incidence and handling of skin diseases of military importance. The incidence of dermatoses is modified by the existence of larger groups in the military population, increased physical exertion, reduced sanitation, and restricted therapeutic facilities. In contrast to the average civilian family of three, the average military group consists of approximately 60 men. These larger groups must live in whatever environment the military situation demands. Even in barracks in the zone of the interior soldiers undergo greater physical exertion, perspire more freely, and have restricted facilities for bathing, laundry, and other sanitary measures.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: M. C. A. U. S.*Received for publication August 24, 1943.Lecture in the second series of a course in the Professional Aspects of Military Medicine, George Washington University School of Medicine, July 16, 1943. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1944Volume 20, Issue 3Page: 395-404KeywordsArmed forcesDermatologyMilitary medicineSanitationSkin diseases ePublished: 1 December 2008 Issue Published: 1 March 1944 PDF downloadLoading ...
THE INTERPRETATION OF METABOLISM DATA
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Interferon joins attack on severe laryngeal papilloma
Authors: E. C. White
Journal: JAMA (1983)

Jennifer, a 3-year-old from Memphis, had laryngeal papilloma of such severity that she required laser surgery every two or three weeks. Tracey, 5 years old, was being treated for asthma in Kansas City and nearly died of asphyxia before laryngeal papilloma was diagnosed. A tracheotomy had to be performed. Chris, 24 years old, is an unusually "old" laryngeal papilloma patient living in St Louis. He had endured countless laryngoscopies and surgical procedures throughout his life, with little hope for a better existence. Until now. These patients are participants in a multi-institutional study to determine the effects of a synthetic interferon-α (Wellferon—made by Burroughs Wellcome Co) in the treatment of laryngeal papilloma. All have shown improvement. Jennifer, in fact, can go more than twice as long between surgeries; after two months, she is only beginning to show signs of relapse. The coordinating center for the study is at the Johns Hopkins