tbuckley/cabot-search huggingface dataset:
High-density lipoprotein cholesterol measurements. A help or hindrance in practical clinical medicine?
Authors: H. R. Superko
Journal: JAMA (1986)

Often, plasma high-density lipoprotein cholesterol (HDLC) measurements lack sufficient accuracy to be of practical use in an individual clinical setting. Recent clinical investigations have demonstrated the strong predictive value of HDLC concentration for future coronary events and rate of progression of angiographically assessed coronary atherosclerosis. Clinical demand for HDLC measurements by clinicians has increased after the announcements of these results. The ability of clinical laboratories to assess HDLC values accurately, so that they may be applied on an individual basis, may be lacking, and enhanced accuracy should be encouraged. (JAMA 1986;256:2714-2717)
van de Vosse et al. Antisense-mediated exon skipping to correct IL-12Rβ1 deficiency in T cells. Blood. 2009;113(19):4548–4555.
Authors: Esther Van De Vosse, Els Verhard, Roelof De Paus, Gerard Platenburg, Judith Van Deutekom, Annemieke Aartsma-Rus, Jaap Van Dissel
Journal: Blood (2009)
Amebic abscess of the liver. Treatment failure with metronidazole
Authors: R. M. Henn
Journal: JAMA (1973)

A patient with amebic abscess of the liver was treated with standard doses of metronidazole but remained febrile and pulmonary complications developed. Only after other forms of treatment including aspiration and administration of chloroquine phosphate and emetine hydrochloride did he begin to improve and ultimately to recover.
New Procedure Offers Hope for Infertile Women
Journal: JAMA (1981)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cardiac safety profile of patients receiving high cumulative doses of pegylated-liposomal doxorubicin (PLD): Use of left ventricular ejection fraction (EF).
Authors: Keith M. Skubitz, Anne Hudson Blaes, Suma Konety, Gary S. Francis
Journal: Journal of Clinical Oncology (2017)

e14016 Background: The use of doxorubicin (D) is limited by cardiotoxicity. Cumulative dose is an important risk factor for D-induced heart failure (D-HF). Retrospective studies found a ~7.5% incidence of clinical HF at a cumulative dose of 550 mg/m2, and prospective trials have found even higher rates. The administration of D by continuous intravenous infusion (CIVI) has less cardiotoxicity than when given by bolus administration. Pegylated-liposomal doxorubicin (PLD) has a longer half-life in blood, and may have lower cardiotoxicity. Limiting D use based on ejection fraction (EF) is commonly performed. Despite the wide use of EF to monitor D-HF, evidence for its utility to predict D-HF is limited, and monitoring adds cost. There is even less information regarding large cumulative doses of PLD and its effect on D-HF and EF. We examined the incidence of D-HF in patients who received a large cumulative dose of D as PLD, and its relation to EF and HF. Methods: A retrospective chart review of patients who received a large cumulative dose of PLD, sometimes following previous free D, was performed. Results: Definite clinical D-HF was not observed in 53 patients who received a cumulative D dose (free + PLD) of &gt; 450 mg/m2, 46 of whom received &gt; 500 mg/m2, 26 &gt; 700 mg/m2, 14 &gt; 1000 mg/m2, and 5 &gt; 1400 mg/m2. The EF varied greatly over time in some patients in the absence of symptoms or signs of HF and was not a reliable predictor of the development of heart failure. Conclusions: The findings provide further evidence for the low risk of D-HF with PLD. Although this study is subject to the usual limits of a retrospective study, the doses received and long-term follow-up are noteworthy. While the determination of EF is commonly used to monitor D cardiotoxicity, it has many limitations. Serial monitoring of EF during treatment may not be helpful, at least in the case of PLD and CIVI-D in adults. Indeed, given the lack of prognostic clarity regarding modest EF changes, regular measurement of EF may sometimes inappropriately limit patient access to this useful drug. These findings may not apply to children or other liposomal formulations, such as non-pegylated formulations.
Positional Right-to-Left Shunting
Authors: R. Scott Wright
Journal: Annals of Internal Medicine (1993)

Letters15 March 1993Positional Right-to-Left ShuntingR. Scott Wright, MD and G. S. Reeder, MDR. Scott Wright, MDSearch for more papers by this author and G. S. Reeder, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-118-6-199303150-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Our observations regarding platypnea and orthodeoxia were based on the clinical appearance and arterial saturation changes observed at the bedside; the patient's precipitous deterioration precluded more extensive evaluation by tilt-table testing using echocardiography or subsequent catheterization [1]. However, we presumed that the increased right-to-left shunting across the atrial septal defect was due to preferential streaming of blood from the inferior vena cava associated with upright posture as described in the case by Sorrentino and Resnekov [2] and previously from our institution [3] in seven cases documented by catheterization, right atrial angiocardiography, and tilt-table contrast echocardiography.Why positional change ...References1. Wright RS, Simari RD, Orszulak TA, Edwards WD, Gleich GJ, Reeder GS. Eosinophilic endomyocardial disease presenting as cyanosis, platypnea and orthodeoxia. Ann Intern Med. 1992; 117:482-3. Google Scholar2. Sorrentino MJ, Resnekov L. Patent foramen ovale associated with platypnea and orthodeoxia. Chest. 1991; 100:1157-8. Google Scholar3. Seward JB, Hayes DL, Smith HC, Williams DE, Rosenow EC, Reeder GS, et al. Platypnea-orthodeoxia: Clinical profile, diagnostic workup, management, and report of seven cases. Mayo Clin Proc. 1984; 59: 221-31. Google Scholar Author, Article, and Disclosure InformationAuthors: R. Scott Wright, MD; G. S. Reeder, MD PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byLeukocytosis and the Retinoic Acid Syndrome in Patients With Acute Promyelocytic Leukemia Treated With Arsenic Trioxide 15 March 1993Volume 118, Issue 6Page: 473-474KeywordsAngiocardiographyAtrial septal defectBloodCatheterizationEchocardiographyHeartInferior vena cavaPatient advocacyPostural control ePublished: 15 August 2000 Issue Published: 15 March 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
JAMA Reference Directories
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
. . . and Quality Care for the Poor
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Gram-negative bacillary meningitis therapy. Polyradiculitis following intralumbar aminoglycoside administration
Authors: J. W. Hollifield
Journal: JAMA (1976)

Gram-negative bacillary meningitis is a serious threat to patients with head trauma or altered immune systems, or those who have had neurosurgical procedures. The aminoglycoside antibiotics administered systemically and into the cerebrospinal fluid (CSF) have proved useful in the treatment of these infections. Intralumbar and parenteral gentamicin sulfate and tobramycin sulfate were administered to an acromegalic woman with<i>Klebsiella</i>meningitis. She had objective evidence of an adhesive arachnoiditis and symptoms of polyradiculitis. Cessation of the aminoglycoside administration resulted in symptomatic improvement, and reinstitution of therapy caused a recurrence of neurologic symptoms. Polyradiculitis may be a complication of the intralumbar administration of aminoglycosides. (<i>JAMA</i>236:1264-1266, 1976)
Section 60.—Osteitis Pubis
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Acute hypertension as an adverse effect of pyrazinamide
Authors: J. Goldberg
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Polymicrobial polyarticular septic arthritis
Authors: B. G. Petty
Journal: JAMA (1983)

A bacteriology technologist was found to have acute polyarticular arthritis after a brief prodromal illness. Gram's stain of fluid from the right knee showed pleomorphic gram-negative organisms, while that of fluid from the right elbow and left wrist showed gram-negative cocci and diplococci. Culture of fluid from the right knee yielded<i>Salmonella enteritidis</i>. Cultures of fluid from all other joints, collected after starting therapy, were negative. An enzyme-linked immunosorbent assay of fluid from the right elbow confirmed<i>Neisseria meningitidis</i>, group C. This organism was also isolated from the patient's throat. This case represents concurrent infection of separate joints by two bacterial pathogens, one confirmed by culture and one by current immunodiagnostic techniques. (<i>JAMA</i>1983;249:2069-2072)
Response to Letter to the Editor
Authors: S Störk
Journal: Cardiovascular Research (2002)

effect of ACE-inhibition and estrogens can be discerned.We thank Drs Jilma and Jilma-Stohlawetz for theirClearly, subgroups in our study were too small to draw interesting comments on our study on MCP-1 lowering conclusions in this regard.effects of HRT in postmenopausal women [1].Their finding of lower MCP-1 levels in 38 premenopausal women compared to 58 men [2] confirmed data from Inadera et al. taken from a cohort of 405 Japanese healthy subjects [3].Lower levels of MCP-1, depending on the R eferences phase in the menstrual cycle, were observed by Jilma et al. in a group of 18 women.This is of interest, but does not [1] Stork S, Baumann K, von Schacky C, Angerer P. The effect of establish causality.Therefore, in our opinion, concluding 17beta-estradiol on MCP-1 serum levels in postmenopausal women.''female sex hormones decrease MCP-1 levels'' is not
Abstract 5266: Kinetic measurements of intracellular ATP levels in co-culture models using live-cell analysis
Authors: Cicely L. Schramm, Michael L. Bowe, Laura A. Skerlos, Grigory S. Filonov, Yong X. Chen, Daniel M. Appledorn
Journal: Cancer Research (2019)

Abstract Differential metabolic requirements of tumor cells have gained recognition as attractive therapeutic targets. For example, clinical trials are currently underway to test the efficacy of the glutaminase-1 (GLS1) inhibitor CB-839 in a variety of indications, including triple-negative breast cancer (TNBC). Standard approaches to monitoring drug induced metabolic perturbations are limited to endpoint assays that lack cell-specific data in complex co-culture models and provide limited kinetic information. Here we describe a live-cell approach to image and analyze intracellular ATP levels of tumor cells in mono- or co-culture over time using the IncuCyte® CytoATP Sensor. A panel of breast cancer cell lines stably expressing a genetically encoded, fluorescent ATP sensor or a control (non-ATP binding) sensor were generated and cultured alone or with a monolayer of stromal cells. The effect of CB-839 treatment on tumor cell ATP levels was monitored over days and analyzed using the IncuCyte® S3 for Metabolism, which is equipped with a specialized optical module and image acquisition mode. In concordance with previous results, TNBC cell lines were more sensitive to GLS1 inhibition than their receptor-positive counterparts. Across all TNBC lines tested, CB-839 treatment resulted in a reduction in intracellular ATP that was sustained for the duration of the 3-day time course. In contrast, most receptor-positive cell lines displayed little to no effect of GLS1 inhibition. In some cases, a transient reduction followed by recovery within 48 hours was observed, highlighting the value of kinetic analysis. Co-culture with CCD-1086SK fibroblasts attenuated the effect of CB-839 in TNBC cell lines. This was not due to drug buffering, as the reduction in ATP induced by CB-839 treatment of MCF7 cells was unaffected by co-culture with stromal cells. Visualization tools included in the IncuCyte® ATP Analysis Software Module provide a quick, qualitative assessment of data across the assay plate and a view into the heterogeneity of responses to treatment. Measurements of proliferation, cell death, and mitochondrial membrane potential provided additional data supporting the observations generated via ATP readout. Overall, these data highlight the value of live-cell, kinetic analysis of metabolic and cell health measurements. Citation Format: Cicely L. Schramm, Michael L. Bowe, Laura A. Skerlos, Grigory S. Filonov, Yong X. Chen, Daniel M. Appledorn. Kinetic measurements of intracellular ATP levels in co-culture models using live-cell analysis [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 5266.
Of platelets, their antagonists, and transient cerebral ischemia
Authors: D. J. Dalessio
Journal: JAMA (1978)

Call me platelet. Consider the lowly platelet if you will— burdened with an undistinguished name, certainly the least interesting of the formed elements of the blood when viewed adjacent to the ebullient eosinophil, the bristling basophil, and the harlequin polymorphonuclear leukocyte. Yet rather than being merely adequate, to cite the laboratory technician's usual cant, it turns out that the platelet is something of a metabolic furnace. It possesses all of the enzymes of the glycolytic pathway, the pentose shunt, and the citric-acid cycle, besides being capable of protein and lipid synthesis.<sup>1,2</sup>Platelet functions are equally impressive, including the evolution of clotpromoting activity and the liberation of vasoactive amines that contribute to inflammation. In a statistical sense, the relationship of transient ischemic attack (TIA) to cerebral infarction is not entirely clear, but to the clinician, it is safe to say that the TIA is a harbinger of a major cerebral
Esophageal mythology
Authors: C. S. Price
Journal: JAMA (1978)

RECENT trends in the diagnosis and management of esophageal disorders have led to an outpouring of articles concerned with clarifying the mechanisms behind these disorders. As new data became available, certain well-entrenched "truths" are found to be myths. This report reviews some of the commonly held beliefs pertaining to certain diseases affecting the esophagus and offers some new perspectives based on recently acquired knowledge. <h3>Myth 1</h3><h3>Hiatal Hernia is the Major Factor Responsible for Gastroesophageal Reflux.—</h3> It is true that a high percentage of patients with reflux symptoms have a hiatal hernia, and for many years this association was believed to indicate a cause-and-effect relationship. It is important to put this observation into a more realistic perspective based on information that is currently available. A sliding hiatal hernia is a common phenomenon that can be demonstrated in up to 33% of young volunteers.<sup>1</sup>In addition, a hernia of this
Adefovir Dipivoxil for the Treatment of Hepatitis B e Antigen–Negative Chronic Hepatitis B; Adefovir Dipivoxil for the Treatment of Hepatitis B e Antigen–Positive Chronic Hepatitis B
Journal: New England Journal of Medicine (2003)

Correction from The New England Journal of Medicine — Adefovir Dipivoxil for the Treatment of Hepatitis B e Antigen–Negative Chronic Hepatitis B; Adefovir Dipivoxil for the Treatment of Hepatitis B e Antigen–Positive Chronic Hepatitis B
Incorrect Data and Year of Publication.
Journal: JAMA (1994)

—In the article entitled "Clinical Effectiveness of Influenza Vaccination in Manitoba," published in the October 27,1993, issue ofTHE JOURNAL(1993;270:1956-1961), errors occurred in the text and reference list. On page 1958, third column, first paragraph, the last sentence should read: "For hospital admission with all respiratory conditions, vaccination was somewhat less effective: 15% to 27% [not 26% to 34%] in 1982 to 1983 and 31% to 34% [not 15% to 32%] in 1985 to 1986." On page 1961, the year of publication for reference 22 was 1986 (not 1991).
Sequential computerized axial tomography in tuberculous meningitis
Authors: D. L. Stevens
Journal: JAMA (1978)

RECENT reports have stressed the value of computerized axial tomography (CAT) of the head in the evaluation of space occupying intracranial lesions including brain abscesses.<sup>2</sup>We recently treated a patient with tuberculous meningitis in whom CAT scanning showed two complications, tuberculoma formation and hydrocephalus. <h3>Report of a Case</h3> A 32-year-old man was admitted to the hospital on Feb 24, 1976, with a five-day history of headache and insomnia, followed by progressive lethargy and incoordination. A chest roentgenogram showed numerous nodular densities throughout both lungs, and a spinal fluid examination showed a polymorphonuclear leukocyte count of 6/cu mm. Findings of the remainder of the examination were normal, and ampicillin sodium and gentamicin sulfate therapy was started for presumed diazepam intoxication with aspiration pneumonia. Because of progressive deterioration of his clinical status, he was transferred to Brooke Army Medical Center on Feb 28, 1976, nine days after the onset of his