tbuckley/cabot-search huggingface dataset:
PREMENSTRUAL SYNDROMES
Authors: Meir Steiner, MD, PhD, FRCPC
Journal: Annual Review of Medicine (1997)

▪ Abstract The recent inclusion of research criteria for premenstrual dysphoric disorder in the fourth edition of the Diagnostic and Statistical Manual of Mental Disorders should help physicians recognize women with symptoms of irritability, tension, dysphoria, and lability of mood that seriously interfere with their lifestyle. Premenstrual dysphoric disorder can be differentiated from premenstrual syndrome, which is primarily reserved for milder physical symptoms and minor mood changes. The use of criteria from the Diagnostic and Statistical Manualin conjunction with prospective daily charting for at least two menstrual cycles is now accepted as common practice in confirming the diagnosis. Treatment options range from the conservative (lifestyle and stress management) to treatment with psychotropic medications and hormonal or surgical interventions to eliminate ovulation for the more extreme cases. Results from several randomized, placebo-controlled trials have clearly demonstrated that selective serotonin reuptake inhibitors, as well as medical or surgical oophorectomy, are effective in treating premenstrual dysphoric disorder. Taken together, these data indicate that treatment may be accomplished by either eliminating the hormonal trigger or by reversing the sensitivity of the serotonergic system.
Methylsulfonyl Metabolites of PCBs and DDE in Human Milk in Sweden, 1972-1992
Authors: Koidu Noren, Asa Lunden, Eva Pettersson, Ake Bergman
Journal: Environmental Health Perspectives (1996)

A multicomponent method used for analysis o°b iphenyls (PCBs), napht , dib analysis.of y nIo of d (M `O2-DDE in human Mlk T t partitining.Adtonal p-O and permeation chromography.Te mean reoeri dards, added to the milk before aion, were dur 1972
The Twenty-second Annual Report of the Secretary of the Michigan State Board of Health, for the year ending June 30, 1894
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Primary herpes simplex infection following mouth-to-mouth resuscitation
Authors: A. A. Hendricks
Journal: JAMA (1980)

CARDIOPULMONARY resuscitation (CPR) is a lifesaving technique that has been widely taught to medical and allied health personnel. Standard references on CPR have emphasized patient benefits without discussing risks or necessary follow-up precautions for the person performing or receiving resuscitation. We report a case of a primary herpes simplex infection acquired by a physician from mouth-to-mouth resuscitation of a patient with herpes simplex pneumonia. <h3>Report of a Case</h3> A 27-year-old male physician performed mouth-to-mouth resuscitation on a 51-year-old debilitated woman in respiratory arrest. Herpes simplex subsequently grew from a culture of her sputum. At autopsy, discrete ulcers containing multinucleated giant cells were seen on her tongue, trachea, and esophagus. An organizing pneumonia was found in both lungs, and herpes simplex, type 1, was cultured from lung tissue. Three days after the resuscitation, the physician noted tender, submental, and cervical lymphadenopathy. Discrete, painful, papulovesicular lesions appeared over his beard area on
Developing and validating the Cutaneous WARTS (CWARTS) diagnostic tool: a novel clinical assessment and classification system for cutaneous warts
Authors: G.K. Hogendoorn, S.C. Bruggink, K.E. Hermans, S.T.P. Kouwenhoven, K.D. Quint, R. Wolterbeek, J.A.H. Eekhof, M.N.C. de Koning, R. Rissmann, J. Burggraaf, J.N. Bouwes Bavinck
Journal: British Journal of Dermatology (2018)

Not all skin (cutaneous) warts look the same. This study from the Netherlands aimed to develop and test an accurate diagnostic tool to help clinicians diagnose warts. The authors defined nine characteristics of appearance using literature and interviews with experts. This led to the development of the Cutaneous WART Diagnostic tool (the CWARTS diagnostic tool). The study consisted of two parts. In the first part, part A, 28 researchers (‘observers’) assessed photographs of 10 warts and the team investigated how well the researchers agreed with each other. In the second part, part B, this was repeated with 6 researchers and 299 warts and the team tested how consistent these 6 observers were between a first and second assessment after a period of 1 week or longer. For the nine characteristics of warts a widely used reliability index, named the intraclass correlation coefficient (ICC), was calculated. In other words, if the ICC is higher it means there is more agreement between observers or observers are more consistent. Presence of black dots had an excellent agreement between observers (0.85), followed by arrangement of the warts (0.65), presence of redness at the border of a wart (0.64) and contrast of the border (0.60). In part B of the study these results were similar. For consistency between a first and second assessment, presence of black dots again had the highest consistency followed by presence of border redness (0.64) and the colour of the wart (0.55). With this study the authors demonstrated that the appearance of cutaneous warts can be reliably assessed with the CWARTS diagnostic tool.
146P Tolerability and pharmacokinetics (PK) of ABT-414 in Japanese patients (pts) with recurrent malignant glioma
Authors: Y. Narita, M. Nagane, N. Kagawa, K. Mishima, T. Yamamoto, T. Wakabayashi, T. Hamada, R. Odagawa, Y. Nishimura, T. Kiriyama, H. Xiong, C. Ocampo, R. Nishikawa
Journal: Annals of Oncology (2016)
Induction of Mutation Spectra by Complex Mixtures: Approaches, Problems, and Possibilities
Authors: David M. DeMarini
Journal: Environmental Health Perspectives (1994)

More complex environmental mixtures have been evaluated for mutagenic activity at the hisD3052 allele of Salmonella, primarily in strain TA98, than in any other target or mutation assay.Using colony probe hybridization to detect a common hot spot deletion, followed by polymerase chain reaction and DNA sequencing, we have generated 10 mutation spectra from three classes of mixtures (i.e., urban air, cigarette smoke condensate, and municipal waste incinerator emissions).The mutation spectra are distinctly different among the three classes of mixtures; however, the spec- tra for samples within the same class of mixture are similar.In addition to the hot spot mutation, the mixtures induce complex mutations, which consist of a small deletion and a base substitution.These mutations suggest a mechanism involving misinsertion of a base opposite a DNA adduct followed by a slippage and mismatch.A role for DNA secondary structure also may be the basis for the mutational site specificity exhibited by the various mixtures.The results suggest that unique mutation spectra can be generated by different classes of complex mixtures and that such spec- tra are a consequence of the dominance of a particular chemical class or classes within the mixture.The problems associated with this type of research are discussed along with the potential value of mutation spectra as a tool for exposure and risk assessment.-
注射后四周血液中的乌司奴单抗药物浓度与中度至重度银屑病对治疗的反应有关
Authors: N. Van den Berghe, E. De Keyser, R. Soenen, L. Meuleman, S. Lanssens, A. Gils, J. Lambert
Journal: British Journal of Dermatology (2020)

银屑病是一种慢性炎症性皮肤病,会导致皮肤发红、发痒和鳞斑。它影响大约 2%‐3% 的西方人口。在中度至重度病例中,患者会使用乌司奴单抗等生物药物治疗。 尽管已证明这些药物可改善患者的症状,但仍有一些个体对治疗无反应,意味着他们看不到任何改善,或者随着时间的流逝失去反应,意味着改善程度有所降低。 失去反应的原因之一是患者血液中的药物浓度过低。因此,测定药物浓度以了解患者体内药物的状况或许是个有吸引力的研究方向。但是,仅当药物浓度与皮肤疾病的状况有关时,测定药物浓度才有用。 这项在比利时进行的研究旨在确定乌司奴单抗药物的浓度是否与临床反应(症状是否有所改善)相关。因此,在注射乌司奴单抗后四周,对 49 例中重度银屑病患者的血液中乌司奴浓度进行了测定。 作者发现,乌司奴单抗浓度较高的患者比浓度低的患者具有更好的临床反应。此外,他们确定了在第 4 周获得最佳反应所需的最小乌司奴单抗血药浓度。 借助此信息,皮肤科医生可以测定药物浓度,以识别由于药物浓度不足而对治疗没有充分反应的患者。在这种情况下,可以调整患者的剂量以获得更好的反应,从而改善生活质量。 本摘要涉及研究: 中度至重度银屑病患者的临床反应与注射后 4 周乌司奴单抗浓度相关
Online tailored intervention, http://www.voorkomblessures.nl, effective on injury preventive behaviour of dutch runners
Authors: S Kloet, L Adriaensens, L Harting, M Fabrie, B van Huik, S Kraaij
Journal: British Journal of Sports Medicine (2011)

Background On a population of 10 million sportsmen in the Netherlands, 3.6 million sports injuries are sustained each year. Behaviour is essential in preventing those injuries. An online tailored intervention, http://www.voorkomblessures.nl , provides Dutch amateur athletes with sport-specific and personalised (tailored) advice. Objective To test the effectiveness of the online intervention on (determinants of) behaviour to prevent sports injuries among amateur runners between 18 and 35 years old. Design In a prospective randomised controlled trial participants were randomly assigned to: experimental group 1 (with baseline), experimental group 2 (without baseline) or control-group. Baseline, 30 min follow up and 3 month follow up data were obtained through online questionnaires between September 2009 and February 2010. Setting Real life setting. Participants After selection on age (18–35), skill level (amateur) and familiarity with the intervention (none) 318 of 352 recruited runners were included in the study and participated at baseline and 30 min follow up measurement. 199 runners participated at 3 month follow up. Intervention Participants in both experimental groups had to view the online intervention for 30 min. Respondents in the control group had to read non running related magazines for 30 min. Main outcome measurements The intervention aims to influence taking four preventive behaviours and/or change their determinants. Results At 30 min follow up significant effects of the intervention are found on various determinants: attitude, risk perception, knowledge and intention. At 3 month follow up significant effects are found on the determinants knowledge and risk perception. More importantly significant effects are shown on two injury preventive behaviours. Conclusions This study shows the online intervention http://www.voorkomblessures.nl succeeds in positively influencing the (determinants of) injury preventive behaviours. More research is needed on long term effects and effects on other types of sport.
TYPHOID FEVER IN CHICAGO.
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Perspectives on the future of AIDS
Authors: T. C. Quinn
Journal: JAMA (1985)

In the relatively short span of three years, over 7,000 cases of the acquired immunodeficiency syndrome (AIDS) have been diagnosed in the United States<sup>2</sup>Preliminary surveillance reports also estimate over 500 cases in the rest of the Americas, 600 in Europe, and several thousand cases in central Africa.<sup>3</sup>With a mortality rate that, two years from diagnosis, exceeds 80%, this illness now ranks as one of the most serious epidemics confronting man in modern time. Medical scientists were recently rewarded with the recovery of a type C human retrovirus from AIDS patients and patients with prodromal signs and symptoms of AIDS.<sup>4,5</sup>While this retrovirus, referred to as "human T-cell lymphotropic virus" (HTLV-III) or "lymphadenopathy-associated virus" (LAV), has not been definitively proved to be the etiologic agent of AIDS, all available evidence strongly supports its causal role. The virus has been cultured from lymphocytes, lymph nodes, semen, and saliva
Detection of hepatitis C virus antibodies and hepatitis C virus RNA in patients with alcoholic liver disease
Authors: S Nishiguchi
Journal: Hepatology (1991)

The relationship between alcoholic liver disease and hepatitis C virus was studied in 80 patients by searching for hepatitis C virus RNA with the polymerase chain reaction and by measuring hepatitis C virus antibodies. By C-100 enzyme-linked immunosorbent assay, hepatitis C virus antibodies were found in 2 of 10 patients with fibrosteatosis, 8 of 20 patients with alcoholic hepatitis, 14 of 19 patients with chronic hepatitis and 19 of 31 patients with cirrhosis. Percentages of patients with antibodies found by C-100 radioimmunoassay and by enzyme-linked immunosorbent assay based on sequence peptide 42 were lower; of the 16 patients with a low titer by C-100 enzyme-linked immunosorbent assay, 10 were negative by radioimmunoassay and 6 were negative by sequence peptide 42. By a second-generation recombinant immunoblot assay, hepatitis C virus antibodies were found in 1 of 10 patients with fibrosteatosis, 2 of 20 patients with alcoholic hepatitis, 15 of 19 patients with chronic hepatitis and 18 of 31 patients with cirrhosis. Hepatitis C virus RNA was found in 1 of 10 patients with fibrosteatosis, 3 of 20 patients with alcoholic hepatitis, 13 of 19 patients with chronic hepatitis and 20 of 31 patients with cirrhosis. Of the 37 patients with hepatitis C virus RNA, 31 had antibodies by C-100 enzyme-linked immunosorbent assay (25 patients at a high titer [cut-off index >6]), and 31 had antibodies by second-generation recombinant immunoblot assay. Patients with cirrhosis and hepatitis C virus RNA had higher ALT activity than such patients without hepatitis C virus RNA (p < 0.05). Of the 80 patients, 25 patients stopped drinking, 11 of these patients had hepatitis C virus RNA. The ALT of the 11 patients tended to decrease during hospitalization but increased in 7 of 11 after discharge. Of the 14 patients without hepatitis C virus RNA who stopped drinking, ALT decreased significantly (p < 0.01) during hospitalization and increased only in 3 of the 14 after discharge. The histological activity index of Knodell for patients with fibrosis, chronic hepatitis or cirrhosis with hepatitis C virus RNA was 11.8 ± 4.2, but without hepatitis C virus RNA it was 8.4 ± 4.3 (p < 0.01). Patients with hepatitis C virus RNA had worse periportal and bridging necrosis, intralobular degeneration, focal necrosis and portal inflammation than patients without hepatitis C virus RNA. (HEPATOLOGY 1991;14:985–989.)
Missing Credit Line
Journal: JAMA (1989)

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PUBLIC HEALTH &amp;amp; PREVENTIVE MEDICINE
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
On the Use of Obstetric Instruments
Authors: J. G. Swayne
Journal: BMJ (1869)

Uan. 23, i869. (p.x23); and Aetius expresses a similar opinion in very decided terms: " Siquis igitur mox in principio aut coacervatim, ea quae efferentur co- hibere aggrediatur, is majoris mali auctor erit."Finally, Dr. Johnison says, " There is no disease which so forcibly impresses upon us the necessity of a cathartic method of treatment, in the widest sense of that terii" (p.125); while Aetius says, " Adjuvare etiam oportet per sedem excretionem."Aetius, having condemned "repressive drugs", and prorounced them to be useless, tells us that the patients " evacuatione opus habent", and advises that, wlheni the discharges are not freely carried off, vomiting should be excited by tepid water, and the patient be directed to vomit.He objects to sweetened water, but recommends "aqua vero oleo mixta", which "auget fluxiones"; and adds, "Per vomitus itaque oppor- tunam provocationem, vomitus ipse solvitur et cessat."I may add.that Aetius recommends, in the advanced stage of the dis- ease, the moderate use of a mild astringent w,ine; and that an attempt should be made to procure sleep, for which purpose he prescribes a de- coction of poppy-heads with starch to be administered as an enema.It is worthy of observation, that every particular of the treatment of chiolera recommended in the brief account of the disease given by Aetius is sanctioned by the high and respected authority of Sir Thomas Watson.
The Cover
Authors: M. Therese Southgate
Journal: JAMA (1994)

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Microwave ovens
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Chernobyl hero (and victim) fighting for life in American hospital
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal