tbuckley/cabot-search huggingface dataset:
Television medicine
Authors: K. Halnan, T B Brewin
Journal: BMJ (1978)

<b>Introduction:</b> Dual bronchodilation (DB) is a core treatment approach in COPD management. Despite this, real-world data on current practice of DB are limited in Russia. <b>Aims and Objectives:</b> To assess the current clinical practice of DB prescription, disease characteristics and clinical profile of COPD patients based on real-world data. <b>Methods:</b> Data were obtained from the Russian COPD registry: a real-world observational study in outpatient sites (NCT02853383). <b>Results:</b> A total of 2,020 COPD patients were enrolled in the registry. 742 (37%) were treated by fixed DB combination: 43% indacaterol/glycopyrronium (IND/GLY), 42% olodaterol/tiotropium (OLO/TIO), 11% vilanterol/umeclidinium (VIL/UME), 4% formoterol/aclidinium (FOR/ACL). In DB group, the average age was 65.9±9.2 years, 75.5% were men. The mean pack-years of smoking was 39.1, 52% were current smokers. 51% of patients had GOLD B and 58% GOLD II (mean FEV1 58.5 ± 18.8%). The main reported phenotypes were chronic bronchitis (41%), emphysematous (27%), phenotype with cachexia (22%). Phenotype with frequent exacerbations was reported in 2%. The annual rate of COPD exacerbations was 1.05 for IND/GLY; 1.17 for OLO/TIO; 1.38 for VIL/UME and 1.73 for FOR/AKL. The most frequent comorbidities were arterial hypertension (51%), ischemic heart disease (34%), chronic heart failure (10%) and osteoporosis (3%). mMRC ≥ 2 was reported in 76% of patients. <b>Conclusion:</b> The majority of patients treated with DB were in GOLD II and GOLD B, highly symptomatic, with high level of cardio-vascular comorbidity and low risk of COPD exacerbations.
THE FUNCTION OF THE ENDOTHELIAL CELLS IN TUBERCULOSIS
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Short-term and long-term epoprostenol (prostacyclin) therapy in pulmonary hypertension secondary to connective tissue diseases: results of a pilot study
Authors: M. Humbert, O. Sanchez, M. Fartoukh, J.-L. Jagot, C. Le Gall, O. Sitbon, F. Parent, G. Simonneau
Journal: European Respiratory Journal (1999)

The aim of this study was to examine the role of p38 mitogen-activated protein (MAP) kinase in interleukin (IL)-8 expression in tumour necrosis factor (TNF)-alpha- and IL-1alpha-stimulated human pulmonary vascular endothelial cells. To this end, the phosphorylation and activation of p38 MAP kinase and the effect of SB 203580, a specific inhibitor of p38 MAP kinase activity, on p38 MAP kinase activity and IL-8 expression in TNF-alpha- and IL-1alpha-stimulated human pulmonary vascular endothelial cells were examined. TNF-alpha- and IL-1alpha- induced phosphorylation and activation of p38 MAP kinase and IL-8 expression in human pulmonary endothelial cells. Inhibition of TNF-alpha- and IL-1alpha-induced p38 MAP kinase activity by SB 203580 inhibited TNF-alpha- and IL-1alpha-induced IL-8 protein production as well as IL-8 messenger ribonucleic acid (mRNA) expression, indicating that SB 203580 was effective at the transcriptional level. These results indicate that p38 mitogen-activated protein kinase plays an important role in the tumour necrosis factor-alpha- and interleukin-1alpha-activated signalling pathway which regulates interleukin-8 expression in human pulmonary vascular endothelial cells.
Peer Review
Authors: Alexander K. C. Leung
Journal: JAMA (1990)

<h3>To the Editor.—</h3> Reviewers are considered the gatekeepers of science. Based on the recommendations of a reviewer, an editor decides whether a manuscript should be accepted, revised, or rejected. We were astonished to learn from the report by Dr Lock and Ms Smith<sup>1</sup>that the average time spent by a reviewer for assessing an article is less than 2 hours. In our experience, the review of a major article for a peerreviewed journal takes approximately 6 to 10 hours depending on the complexity of the subject. In the study by Dr Lock and Ms Smith, the reviewers had considerable experience. They reviewed for an average of five journals during the study period. The average number of years that the reviewers had been qualified in medicine was 24, and the average number of years of experience with reviewing was 10. Of the 301 reviewers, 146 (48.5%) were editors, associate editors, or
THE RADICAL MASTOID OPERATION.
Authors: FRANK ALLPORT
Journal: JAMA (1907)

The radical mastoid operation is employed principally for the permanent cure of intractable chronic purulent otorrhea, and consists essentially in opening the mastoid cells, breaking down the upper portion of the posterior osseous meatus, throwing the cells, antrum, aditus ad antrum, tympanum and meatus into one large cavity, which must be thoroughly cleansed of all pathologic tissue, both soft and osseous, and then covering this large bony surface with new epithelium by means of specially devised flaps, skin grafts and natural healing processes. This procedure is the acme of mastoid surgery, should only be undertaken by an operator of special experience, and is worthy of the continued study of the aural surgeon. Perhaps in no space of similar size in the body is operative work fraught with so much danger as when the surgeon undertakes to break down the innermost portion of the osseous meatus and to remove all pathologic
The Harvard Southern California Chronic Ozone Exposure Study: Assessing Ozone Exposure of Grade-School-Age Children in Two Southern California Communities
Authors: Alison S. Geyh, Jianping Xue, Haluk Ozkaynak, John D. Spengler
Journal: Environmental Health Perspectives (2000)

The Harvard Southern California Chronic Ozone Exposure Study measured personal exposure to, and indoor and outdoor ozone concentrations of, approximately 200 elementary school children 6-12 years of age for 12 months (June 1995-May 1996). We selected two Southern California communities, Upland and several towns located in the San Bernardino mountains, because certain characteristics of those communities were believed to affect personal exposures. On 6 consecutive days during each study month, participant homes were monitored for indoor and outdoor ozone concentrations, and participating children wore a small passive ozone sampler to measure personal exposure. During each sampling period, the children recorded time-location-activity information in a diary. Ambient ozone concentration data were obtained from air quality monitoring stations in the study areas. We present ozone concentration data for the ozone season (June-September 1995 and May 1996) and the nonozone season (October 1995-April 1996). During the ozone season, outdoor and indoor concentrations and personal exposure averaged 48.2, 11.8, and 18.8 ppb in Upland and 60.1, 21.4, and 25.4 ppb in the mountain towns, respectively. During the nonozone season, outdoor and indoor concentrations and personal exposure averaged 21.1, 3.2, and 6.2 ppb in Upland, and 35.7, 2.8, and 5.7 ppb in the mountain towns, respectively. Personal exposure differed by community and sex, but not by age group.
Why does severe coronary stenosis decrease perfusion reserve in the remote myocardium? Olaf M. Muehling, Prasad Panse, Andrey Zenovich, Fan Zhao, Yimei Huang, Abdul Mansoor, Michael Jerosch-Herold, Norbert M. Wilke. Center for Cardiovascular MRI of the Department of Radiology at the University of Minnesota, Minneapolis, MN, Division of Cardiology of the Department of Medicine at the University of Minnesota, Minneapolis, MN
Journal: Journal of the American College of Cardiology (2001)
Impact of Heat Waves on Mortality—Rome, Italy, June-August 2003
Journal: JAMA (2004)

During June-August 2003, record high temperatures were reported across Europe; Italy was one of the countries most affected. To assess the impact of the summer 2003 heat waves on mortality, the Rome Local Health Authority analyzed temperature and daily mortality data for June-August 2003. This report summarizes the results of that analysis, which indicated that an estimated 1,094 excess deaths occurred during three major heat wave periods in 2003, an increase of 23% compared with the average annual number of deaths during 1995-2002. Improvements have been made in warning systems and prevention programs that target persons at high risk to reduce excess mortality during future heat waves.
THE COST OF HOSPITALIZATION
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Phase II study of irinotecan (CPT-11) in children with high-risk malignant brain tumors: The Duke experience
Authors: Christopher D. Turner, Sridharan Gururangan, James Eastwood, Krystal Bottom, Melody Watral, Rodney Beason, Roger E. McLendon, Allan H. Friedman, Sandra Tourt-Uhlig, Langdon L. Miller, Henry S. Friedman
Journal: Neuro-Oncology (2002)
Author Index Vol. 64, 1995
Authors: Gian Paolo Guaraldi, Emanuele Orlandi, Louis A. Gottschalk, Karl Burgoyne, Randolph Swartz, Jambur Ananth, K. Thunedborg, C.H. Black, P. Bech, Nancy J. Keuthen, Richard L. O'Sullivan, Joseph N. Ricciardi, David Shera, Cary R. Savage, Andrea S. Borgmann, Michael A. Jenike, Lee Baer, Paolo Boselli, Pier Luigi Tartoni, Randall S. Jorgensen, Kenneth Abdul-Karim, Todd A. Kahan, James J. Frankowski, Pio Enrico Ricci Bitti, Paola Gremigni, Giorgio Bertolotti, Anna Maria Zotti, Loma K. Flowers, Angela Zettler, Gabriele Duran, Sabine Waadt, Peter Herschbach, Friedrich Strian, Richard L. O'Sullivan, Nancy J. Keuthen, Caroline F. Hayday, Joseph N. Ricciardi, Lynn Buttolph, Michael A. Jenike, Lee Baer
Journal: Psychotherapy and Psychosomatics (1995)
Landmark article, June 19, 1915. The isolation in crystalline form of the compound containing iodin, which occurs in the thyroid. Its chemical nature and physiologic activity. By E.C. Kendall
Authors: E. C. Kendall
Journal: JAMA (1983)

During the past twenty years, investigation has firmly established, among other things, the following two facts: (1) The thyroid contains some substance capable of producing marked physiologic effects, and (2) iodin is a constant constituent of normal and pathologic glands. These two facts are emphasized because most of the controversies concerning the thyroid have arisen from attempts to explain the relation between the physiologic activity and the presence of iodin. It is obvious that no final conclusions could be arrived at until either some substance possessing physiologic activity had been isolated in pure form and shown to be a normal constituent of the gland, or until the compound containing iodin had been isolated in pure form and its physiologic activity determined. Last December I<sup>1</sup>reported the separation from the thyroid of a preparation containing 60 per cent. of iodin. The present paper is a summary of the results thus
A Preliminary Report on the Mortality of Cancer in the United States, as Given by the Census of 1910
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE CURATIVE ACTION OF FLUORESCENCE IN MALARIA.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Errors in Key Points and Corresponding Author Address
Journal: JAMA Network Open (2019)

Florian Roquet, MD; Arthur Neuschwander, MD; Sophie Hamada, MD; Gersende Favé, MD; Arnaud Follin, MD; David Marrache, MD; Bernard Cholley, MD, PhD; Romain Pirracchio, MD, PhD; for the Traumabase Group
Error in Expression of Formula
Authors: Guifeng Xu, Lane Strathearn, Buyun Liu, Wei Bao
Journal: JAMA (2018)

Jacob A. Udell, MD, MPH, FRCPC; Charlie S. Wang, MD, MSc, FRCPC; Jill Tinmouth, MD, PhD, FRCPC; J. Mark FitzGerald, MB, FRCPC; Najib T. Ayas, MD, MPH, FRCPC; David L. Simel, MD, MHS; Michael Schulzer, MD, PhD; Edwin Mak, BASc; Eric M. Yoshida, MD, MHSc, FRCPC
Instrumentation for Negative Ion Detection
Authors: M. McKeown
Journal: Environmental Health Perspectives (1980)

The instrumentation and practical circuitry required for the detection of negative ions exiting the mass analysis section of a mass spectrometer is examined. The potentials needed to bias the electron multiplier when detecting negative ions from a low ion-energy mass spectrometer, e.g., a quadrupole, are contrasted with the biasing requirements of a mass spectrometer having high ion-energies, e.g., a magnetic sector. Methods of decoupling the biasing high voltage on the signal lead of the multiplier in pulse counting measurements are discussed in detail so that normal, ground referenced input, pulse preamplifiers may be used. Easily understood, practical rules for determining the values of circuit components are given together with a simplified theory of transferring pulse signals from multiplier collector to pulse preamplifier. The changes in circuitry needed when attempting to detect ions by current measurement methods from an electron multiplier area detailed. The effects of leakage currents into athe input of the current preamplifier and their avoidance bay using triaxial shielding on vacuum feed-throughs are explained. The article suggests possible methods of decoupling the high voltage referenced input and the ground referenced output of a current measuring preamplifier.
"ELÆOMYENCHYSIS."
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Safety, pharmacokinetics and efficacy of RC48-ADC in a phase I study in patients with HER2-overexpression advanced solid cancer.
Authors: Jifang Gong, Lin Shen, Wenxiang Wang, Jianmin Fang
Journal: Journal of Clinical Oncology (2018)

e16059 Background: Trastuzumab combined with chemotherapy is the standard first-line regimen in HER2- overexpression advanced gastric cancer, and there is no established therapy in the second-line setting. RC48-ADC is a novel humanized anti-HER2 antibody conjugated with Monomethyl Auristatin E (MMAE) via a cleavable linker, which has showed high specificity and potency in vivo and in vitro models of gastric cancer and other solid tumors. Methods: This was an open-label, dose-escalation and dose-expansion study in pts with HER2-overexpression (defined as IHC 2+ or 3+) advanced solid cancers. The dose escalation phase was initialed by accelerated titration (0.1 and 0.5 mg/kg) and then switched to 3+3 scheme (1.0, 2.0 and 2.5 mg/kg, Q2W). In dose expansion phase, pts were given at 2.0mg/kg Q2W. Results: As of Jan 29, 2018, 22 pts (21 gastric cancers and 1 breast cancer) in dose escalation (0.1 - 2.5 mg/kg Q2W, n = 19; 2.0 mg/kg Q3W, n = 3) and 14 pts (11 gastric cancers, 2 urothelial cancers and 1 bile duct cancer) in dose expansion were available for analysis. MTD was not reached at doses up to 2.5 mg/kg Q2W. 35 pts (97.2%) experienced TRAEs, most commonly leucopenia (61.1%), neutropenia (52.8%), fatigue (50.0%), numbness (44.4%), AST elevation (30.6%) and ALT elevation (27.8%). 11 pts (30.6%) developed Grade 3-4 TRAEs including leucopenia (11.4%), neutropenia (11.4%), numbness (11.1%) and fatigue (5.6%), which resolved with dose reduction and supportive care. Anticancer activity was observed in 2.0 and 2.5mg/kg cohort of 24 evaluable pts, reporting 33.3% ORR and 58.3% DCR. 2 PRs were assessed in 1 pt with urothelial cancer and 1 with bile duct cancer. ORR was 40% in low HER2-expression (IHC 2+/FISH-, n = 5) pts and 29.4% in high HER2-expression (IHC 2+/FISH+ or IHC 3+, n = 17) pts. Furthermore, an ORR of 30% and DCR of 60% was found in 10 gastric pts receiving 2.0 or 2.5 mg/kg who had progressed to trastuzumab-based regimens. Conclusions: RC48-ADC has presented a manageable safety profile. It has severity-limited myelosuppression and low liver toxicities. Pts with trastuzumab- pretreated gastric cancer exhibit good response. Dose expansion is on progress. Clinical trial information: NCT02881190.
Mass Exposure to Bats at Air Force Base Leads to Group Screening
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PHS Replies to Critic of Flu Vaccine Safety During Pregnancy
Journal: JAMA (1962)

A consultant to the U.S. Public Health Service disputed published warnings that commercial flu vaccines should not be administered to pregnant women or prospective blood donors with Type O blood. In a statement released by the PHS Communicable Disease Center in Atlanta, Dr. Fred M. Davenport, vicechairman of the Surgeon General's Advisory Committee on Influenza, disagreed with the conclusions of Dr. Georg F. Springer (<i>JAMA</i>, Nov. 3, 1962, advertising page 52). "My considered opinion," Davenport said, "is that it would not be in the public interest to discontinue vaccination of pregnant women or of blood group O potential donors." Here is the complete PSH statement: Rather extensive publicity has been given recently to the findings of Dr. Georg F. Springer and Mr. Harvey Tritel (Immunochemistry Section, William Pepper Laboratory and Department of Medical Microbiology, University of Pennsylvania) indicating that blood group A-like substances could be found in commercially available influenza