tbuckley/cabot-search huggingface dataset:
My Foetus
Authors: Deirdre J Murphy
Journal: BMJ (2004)

Channel 4, 20 April at 11 05 pm Rating: ![Graphic][1]</img> Termination of pregnancy is a difficult issue with rights and wrongs, whatever your personal perspective. It is difficult for patients, it is difficult for health-care professionals, and it is difficult for society. I work as an obstetrician in a city where one in three pregnancies is terminated. It is hard to rationalise an approach that promotes safe motherhood within an environment of high “wastage.” Termination of pregnancy is a bitter fact of life for many people in the United Kingdom and it affects us all in one way or another. I am confused about termination and I am not alone. There is tremendous scope for mainstream medical journalism to contribute to an informed debate, to educate, or even to provoke and challenge the values of sexually active people in this country. And so I watched this Channel 4 documentary with interest. Julia Black, a filmmaker, is in the third trimester of … [1]: /embed/inline-graphic-1.gif
THU0020 Immature Dendritic Cell Are Potent Osteoclasts Precursors in RA and Are Targeted by RA-Specific Antibodies
Authors: A. Krishnamurthy, M. Sun, B. Rethi, V. Joshua, N. Tarasova, H. Wähämaa, K. Amara, V. Malmström, J. Ytterberg, A. Catrina
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> We have recently shown that the immature dendritic cells (iDC) developing in dense cultures in presence of high lactic acid levels can efficiently differentiate into osteoclasts (OC). <h3>Objectives</h3> We aimed to investigate influence of Anti-citrullinated protein antibodies (ACPA) on iDC differentiation to OC in rheumatoid arthritis (RA). <h3>Methods</h3> CD14+ monocytes from PB of ACPA+ RA patients and healthy individuals were first used to generate iDC and MΦ and these cells were then differentiated to OC with RANKL and M-CSF. Mass spectrometry analysis was performed on different stages of differentiation of iDC and MΦ derived OC. ACPA positive and negative polyclonal IgGs were isolated from synovial fluid (SF, n=26) and peripheral blood (PB, n=38) samples of RA patients and the effects of these antibodies was tested in OC cultures. Cytokines were measured by CBA in cultures supernatants. Immunoflourescence was done on OCs with monoclonal ACPAs derived from single SF derived B cells. The effect of IL-8 and PAD inhibition was tested on OC differentiation. <h3>Results</h3> Principal component analysis confirmed distinct proteomics profiles in sparse or dense DC cultures and in MΦ but both DC and MΦ precursors differentiated into OC with similar protein composition. Citrullinated-actin was identified during iDC-OC maturation and citrullinated-vimentin in matured OC. With immunofluorescent staining we demonstrated the presence of citrullinated proteins on the surface of both iDC precursors and iDC-derived mature OCs. PAD2 and PAD4 showed faint staining in CD14 monocytes with increased staining intensity in both iDC precursors and more mature OCs with PAD activity present both in dendritic cells and osteoclasts. Polyclonal ACPAs enhanced osteoclastogenesis and bone resorption from iDC (fold increase 1.6±0.2 for OC number and 2.0±0.3 for bone resorption area). Similar effect was observed when the iDC were derived from ACPA+ RA patients (fold increase of 2.3±0.9 for OC number and 2.6±0.1 for bone resorption area). Monoclonal ACPA9s with certain specificities were able to induce osteoclastogenesis. The importance of citrullination and PAD enzymes for ACPA mediated iDC transdifferentiation to OC was confirmed by a dose-dependent inhibition of OC differentiation using the PAD inhibitor Cl-Amidine. Increased osteoclastogenesis was associated with significantly higher levels of IL-8 levels in ACPA treated culture supernatants (fold increase of 2.4±0.5). Neutralization of IL-8 blocked ACPA induced osteoclastogenesis. <h3>Conclusions</h3> Our results shows iDC can efficiently transdifferentiate in to OC in RA and this process is enhanced by ACPA. We provide evidence on the importance of the IL-8 and PAD enzyme in ACPA mediated osteoclastogenesis. <h3>Disclosure of Interest</h3> None declared
From the NIH: Cholesterol and noncardiovascular mortality
Journal: JAMA (1981)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Journal club
Authors: Kathryn Le Grice
Journal: Thorax (2020)

HigH-flow Humidified tHerapy for Copd at HomeHome non-invasive ventilation (NIV) improves outcomes in patients with COPD and chronic hypercapnia; however, it is not always well tolerated.High-flow humidified therapy (HFH) offers an alternative more acceptable long-term therapy in these patients.Pisani and colleagues (BMC Pulmonary Medicine 2020:20;12) report on the acceptability of HFH to patients and its effectiveness on PaCO 2 reduction.In a pilot study, 50 patients recovering from an acute exacerbation of COPD requiring hospital admission, with persistent hypercapnia but normalised pH on three occasions, were enrolled and started on HFH.An a priori analysis of patients with and without COPD-OSA (obstructive sleep apnoea) overlap was planned.For a 72-hour period, each participant used HFH overnight, plus >8 hours during daytime.Each morning, arterial blood gas result, number of hours of HFH and patient-reported tolerance to therapy (scored 1-5; very bad-very good) were recorded.The therapy was tolerated well by all but one participant (mean patient score 4.0±0.9).Results showed no significant difference in PaCO 2 from baseline overall; however, in patients with COPD without OSA (n=38), PaCO 2 was reduced by ~6 mm Hg (0.8 kPa); p=0.044 at 72 hours.With a lack of control group, it is possible that the improvement in PaCO 2 may represent continued recovery following the acute exacerbation.The study indicates that while HFH may offer an alternative to NIV, the optimum patient group needs to be carefully elucidated and stratified for in future trials.
Intrauterine amputation with the missing member found in the fetal membranes
Authors: R. Torpin
Journal: JAMA (1966)

CONGENITAL malformations, which are not of genetic origin, are now commonly associated with insult and injury to the embryo, usually during the first trimester of pregnancy. However, there are persistent reports throughout the literature which relate certain gross deformities of the fetus to defects in the membranes. Most of these reports are incomplete and represent chance findings. The authors over a period of years have systematically studied some 10,000 fetal membranes. The following case is of interest in that it permits a correlation between the clinical course of a pregnancy and the condition of the membranes and fetus. <h3>Report of a Case</h3> The mother was multipara 4, 30 years of age, whose previous pregnancies were normal. She came under observation in the third month of pregnancy with a report of spotting during the second month. The history was negative for measles, trauma, and infectious disease. In the sixth month amniotic
National Medical Association unveils billboard campaign to promote health in black communities
Authors: A. A. Skolnick
Journal: JAMA (1993)

THE NATIONAL Medical Association (NMA) has joined forces with the Outdoor Advertising Association of America, the US Department of Health and Human Services, and other medical and health groups in a billboard campaign that will bring positive health and social messages into black communities across the United States. The first seven of these billboards were unveiled in August at the NMA's 98th Annual Convention and Scientific Assembly, held in San Antonio, Tex. The NMA, the professional organization whose members are mainly black physicians, is based in Washington, DC. "The goal of the billboard campaign is to communicate positive, culturally relevant health messages to an African-American population disproportionately suffering from diseases which cause sickness and premature death," says Richard O. Butcher, MD, immediate past president of the NMA. Because many of the health problems for which blacks are at higher risk are related to behavior, they are preventable, says Butcher, pointing
THE NAMING OF ANIMAL PARASITES
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE DECREASE OF DRINKING AMONG PHYSICIANS.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Yellow Fever.
Journal: JAMA (1884)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
肉毒毒素的非神经元和非肌肉作用:致命分子治疗人类皮肤病和其他疾病的良机
Authors: S.A. Grando, C.B. Zachary
Journal: British Journal of Dermatology (2018)

肉毒杆菌神经毒素(BoNT)是肉毒杆菌细菌产生的蛋白质。这些毒素有不同亚型,被命名为A至G。A、B和E亚型会造成人体肉毒中毒,是具有致命性的疾病。但是最近,BoNT的一些类型被研发为注射治疗物,用于放松面部肌肉,因而能够减少皱纹(通常以品牌名“Botox”为人所知)。除了著名的美容效果外,A型和B型还可用于治疗各类疾病,主要与肌肉放松相关。这篇来自美国的评论罗列了使用BoNT的很多治疗方法,包括多汗症、家族性良性慢性天疱疮、毛囊角化病、皮褶银屑病和雷诺现象等皮肤病。多项试验研究显示,BoNT/A有助于伤口愈合、减少某些疤痕的厚度,甚至是减少痤疮。
Human-baboon cross-circulation for treatment of hepatic coma
Authors: D. Hollander
Journal: JAMA (1971)

A patient in fulminant hepatorenal failure due to alcoholic hepatitis was cross-circulated with a baboon for 5 1/2 hours. His mentation began to improve during the procedure, concomitantly with improvement in his biochemical abnormalities. Added normalization of results from liver function tests followed a subsequent exchange transfusion. Reevaluation of the patient three months later disclosed no signs of hepatic encephalopathy, no marked biochemical abnormalities, and no immunological sequelae. Heterologous cross-circulation merits further evaluation as a therapeutic modality for fulminant hepatic failure.
Clinical and economic consequences of antiviral treatment for hepatitis C chronic infection in Europe: analysis of England, Italy, Romania and Spain data
Authors: Xhimi Tata, Andrea Marcellusi, Gianluca Fabiano, Stephen Ryder, Maria Buti, Liana Gheorghe, Carmine Coppola, Antonio Craxi, Francesco Mennini, Loreta Kondili
Journal: Journal of Hepatology (2020)
Residents' working hours
Authors: L. Snider
Journal: JAMA (1979)

<h3>In Reply.—</h3> With reference to Dr Plotkin's letter, we agree that our article does not support the conclusion that cefazolin is superior to penicillin G procaine in treating uncomplicated pneumococcal pneumonia. The authors did not mean to imply that cefazolin is an appropriate single agent for the treatment of Gramnegative pneumonias, but merely that if a patient has clinical pneumococcal pneumonia and no organisms seen on Gram's stain of sputum, cefazolin would offer a broader spectrum of coverage than penicillin alone. The elevation of BUN referred to in the article by Gold et al<sup>1</sup>was found in only three patients out of 1,006 and was not associated with any clinical sequelae (personal communication). Cefazolin is an effective agent in treating pneumococcal pneumonia and can be particularly useful in treating patients with a history of penicillin allergy other than the immediate type I hypersensitivity reaction. This represents a significant group
Textbook of Pediatrics
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
13-<i>cis</i> Retinoic Acid and Complete Androgen Blockade in Advanced Hormone-Naive Prostate Cancer Patients: Report of a Phase II Randomized Study
Authors: Anna C. Ferrari, Nelson Stone, Richard Stock, Myron Bednar, Isaac Esseesse, Harvinder Singh, Yvonne Baldwin, John Mandeli
Journal: Journal of Clinical Oncology (2002)

PURPOSE: 13 cis Retinoic acid (isotretinoin) is a retinoid with preclinical evidence of anti–prostate cancer activity. This phase II, cross-over, randomized study of advanced, predominantly androgen-dependent prostate cancer patients was designed to assess primarily the effect on prostate-specific antigen (PSA) decline and toxicity of adding isotretinoin to hormonal therapy and, secondarily, the potential antitumor activity of the combination. PATIENTS AND METHODS: Thirty-seven D0 to D2 patients were randomized soon after initiating luteinizing hormone–releasing hormone agonist with antiandrogen treatment to add (arm 1) or not (arm 2) isotretinoin from weeks 1 to 12. After cross-over on week 13, patients in arm 1 discontinued while patients in arm 2 added isotretinoin from weeks 14 to 25. Observation on hormonal therapy alone continued until week 49. RESULTS: Baseline and randomization median PSA for 30 assessable patients were, respectively, 34 and 18.2 ng/mL for arm 1 and 31 and 13.4 ng/mL for arm 2. Median PSA at week 13 was 0.5 ng/mL (range, &lt; 0.05 to 136 ng/mL) for arm 1 and 0.7 ng/mL (range, &lt; 0.05 to 4.4 ng/mL) for arm 2; at week 25, 0.1 ng/mL (range, &lt; 0.05 to 121 ng/mL) and 0.4 ng/mL (range, &lt; 0.05 to 3.1 ng/mL), respectively. At week 49, arm 1 had median PSA of 0.1 ng/mL (range, &lt; 0.05 to 345 ng/mL) and arm 2, 0.3 ng/mL (range, &lt; 0.05 to 8.8 ng/mL); seven of 15 and three of 15 patients, respectively, had undetectable PSA levels (P = .12). Frequent isotretinoin-related toxicity included grade 1 cheilitis (76%), skin dryness (43%), and elevated triglycerides (50%). CONCLUSION: Isotretinoin does not impair PSA decline or add significant toxicity to hormonal therapy. An adequately powered, randomized study would be required to determine whether the combination is superior to standard hormonal treatment.
News
Journal: Gut (1982)

This is the second year of this Liver annual.Any conscientious reader of this series will certainly be kept abreast with developments in hepatology.The authors of the various sections are experts in their fields, and have been carefully chosen.Similarly, the subjects are relevant.Each essay is not simply a summary of the literature, but includes an interpretation.The present volume includes excellent contributions on hepatic protein metabolism, alcohol and the liver, viral hepatitis, and indeed all the major growing areas in hepatology.There are two problems.The review stops on 30 June 1981, so that the review of the literature is already one year out of date.The enthusiastic research worker will have to keep up with original articles in the journals.The second problem is the almost total lack of illustrative material whether tables or figures.This is presumably house policy, but makes the text much heavier going than it might be.Policy cannot be on cash grounds as the book is well up to the price asked for other better illustrated reviews.This book can be recommended to all practising hepatologists.
Incorrect Negative Predictive Value
Authors: Jose Gereda, Donald Leung, Andrew Liu
Journal: JAMA (2000)

Results.Urban homes had significantly lower house-dust endotoxin levels than farm homes and rural homes in developing countries (PϽ.001,Wilcoxon rank sum test) (FIGURE).Farm barns had significantly higher endotoxin levels compared with both farm homes (PϽ.001, t test) and rural homes in developing countries (P=.03, t test).Farm home and associated barn endotoxin levels were significantly correlated (Spearman r=0.67,P=.02).Comment.Greater levels of exposure to environmental endotoxin from early childhood, especially in rural areas of de-veloping countries and in farming communities, may help explain the low prevalence of asthma and allergies observed in children raised in these environments.If environmental endotoxin exposure in early life has an atopy-protective effect, then T H 1-type activity may be induced separately from exposure to serious infections, thus suggesting a possible strategy for allergy and asthma prevention.
Journal of Laryngology and Otology, London
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal