tbuckley/cabot-search huggingface dataset:
The Propaganda for Reform
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
改变我们的微生物组:皮肤病学中的益生菌
Authors: Y. Yu, S. Dunaway, J. Champer, J. Kim, A. Alikhan
Journal: British Journal of Dermatology (2020)

人体是各种微生物的宿主, 各种微生物合称为微生物组。人类微生物组由寄居在我们身体内及体表上的细菌、真菌、病毒及小节肢动物组成。 此微生物组对人类健康和疾病很重要, 包括皮肤病学。 研究表明, 益生菌或活微生物有助于恢复健康的微生物组群, 并可能给予我们健康益处。此回顾评估了皮肤病学中微生物组的作用, 并提供了支持使用益生菌治疗皮肤疾病的临床数据, 包括口服益生菌以及直接涂抹于皮肤的外用益生菌。 包括不同类型的研究, 例如基本科学、转化研究和临床研究, 其研究了皮肤微生物组的差异以及益生菌对湿疹、痤疮、银屑病、慢性伤口、头屑和某些类型皮肤癌患者的影响。 作者们发现, 只有一些临床试验探索了益生菌对皮肤疾病的有效性, 但已充分研究的湿疹除外。大多数研究使用口服益生菌, 但分析外用益生菌的研究频率不断增加。 一般来说, 可用的临床试验产生了积极的结果, 益生菌使用后皮肤状况得到改善。作者们发现, 益生菌似乎对治疗某些炎性皮肤病很有效, 包括湿疹和痤疮。它们还在伤口愈合和皮肤癌中表现出有前景的作用。但是, 需要更多研究来进一步研究使用益生菌治疗皮肤病的可能性。 This summary relates to the study: 改变我们的微生物组:皮肤病学中的益生菌
P05.65 The caregiver burden in meningioma: long-term results and its effects on caregiver’s health-related quality of life, anxiety and depression
Authors: A H Zamanipoor Najafabadi, P B van der Meer, F W Boele, J C Reijneveld, M J B Taphoorn, M Klein, W R van Furth, L Dirven, S M Peerdeman
Journal: Neuro-Oncology (2018)

Various studies in oncological/neurological patients highlight that informal caregivers suffer from a significant disease burden. We aimed to assess the meningioma caregiver burden, and its effects on caregiver’s health-related quality of life (HRQoL), and levels of anxiety and depression. In a multicentre cross-sectional study informal caregivers of intracranial meningioma patients at a median of 10 years after their last anti-tumour therapy were included. Informal caregivers were family members or close friends and completed the caregiver disease burden scale, SF-36 (HRQoL) and the Hospital Anxiety and Depression Scale. Caregiver burden was assessed as an independent determinant for caregiver’s HRQoL, and levels of anxiety and depression with multivariable analysis correcting for relevant confounders. Participant recruitment is still in progress. 110 informal caregivers were included (mean age: 64.5, female: 37.2%). Informal caregivers reported any caregiver burden in 35.2% of cases, and clinically relevant burden in 15.7%. More specifically, 20.4% of caregivers suffered from stress, 11.2% from social isolation, 13.0% from feelings of disappointment, 21.0% from emotional problems, and 12.0% from environmental factors complicating the care for the patient. The total caregiver burden score was significantly associated with decreased HRQoL on 6/8 scales and 2/2 component scores: physical function (β=-6.53, p=0.071), role limitation due to physical problems (β=-13.62, p=0.041), bodily pain (β=-13.11, p=0.014), social function (β=-11.87, p=0.001), mental health (β=-14.32, p<0.001), vitality (β=-14.24, p=0.001), physical component scale (β=-4.40, p=0.022), and mental component scale (β=-6.09, p<0.001). In addition, the total caregiver burden score was independently associated with higher anxiety (β=3.11, p<0.001) and depression levels (β=4.11, p<0.001). Caregiver burden in informal caregivers of meningioma patients is considerable, negatively affected their HRQoL, and levels of anxiety and depression. Paying more attention to meningioma patients’ caregivers seems therefore warranted, and effective support should be implemented if required.
Pseudodementia
Authors: C E Wells
Journal: American Journal of Psychiatry (1979)

Pseudodementia is the syndrome in which dementia is mimicked or caricatured by functional psychiatric disorders. The author describes 10 patients with pseudodementia and compares its clinical features with those of true dementia. The syndrome occurred in patients with various psychiatric diagnoses, but a striking feature in most patients was marked dependency. The recognition of this clinical syndrome should obviate the need for many neurological diagnostic studies and lead to earlier and more effective psychiatric treatment.
THE NONPROTEIN NITROGENOUS COMPONENTS OF BLOOD
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Significance of Mouse Liver Tumor Formation for Carcinogenic Risk Assessment: Results and Conclusions from a Survey of Ten Years of Testing by the Agrochemical Industry
Authors: Neil G. Carmichael, Harald Enzmann, Ian Pate, Felix Waechter
Journal: Environmental Health Perspectives (1997)

A survey was performed on the results of 138 carcinogenicity studies conducted in various mouse strains by the agrochemical industry over the period 1983-1993. Data for liver tumor incidence, liver weight, and histopathology were collected along with data on genotoxicity. Studies were judged positive or negative for liver tumor formation on the basis of apparent dose response, malignancy, and difference from historical control values using a weight of evidence approach. Thirty-seven studies were judged to be positive for liver tumorigenicity in one or both sexes. There was no evidence showing an influence of the mouse strain and the duration of the study on the proportion of positive studies. Although 8 of the chemicals tested in the 138 studies were positive in the Ames test, only one of these was judged positive for carcinogenicity. Only 6 of the 37 positive chemicals had any other reported positive genotoxicity findings. A clear relationship between hepatomegaly at 1 year after exposure and a positive tumorigenic outcome at 18 months or 2 years after exposure was demonstrated. Whereas the average relative liver weight of top dose animals was 110% of control in negative studies, it was 150% in positive studies. Likewise, very few negative studies demonstrated significant pathological findings after 1 year, whereas the majority of positive studies had significant liver pathology. The implications of these findings for extrapolation to humans are discussed.
From the Centers for Disease Control and Prevention. FDA approval of use of a new Haemophilus b conjugate vaccine and a combined diphtheria-tetanus-pertussis and Haemophilus b conjugate vaccine for infants and children
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Formation of the Metal-Thiolate Clusters of Rat Liver Metallothionein
Authors: Dennis R. Winge, Kirk B. Nielson
Journal: Environmental Health Perspectives (1984)

The isoforms of rat liver apo-metallothionein (MT) were reconstituted in vitro with Cd and Zn ions to study the order of binding of the seven metal sites. Reconstitution with seven Cd ions resulted in a metalloprotein similar to induced Cd,Zn-MT by the criteria of electrophoretic mobility, insensitivity to proteolysis by subtilisin and the pH-dependent release of Cd. Proteolytic digestion of MT reconstituted with sub-optimal quantities of Cd followed by separation of Cd-containing polypeptide fragments by electrophoresis and chromatography revealed metal ion binding initially occurs in cluster A. Upon saturation of the four sites in cluster A, binding occurs in the three metal center, cluster B. Samples reconstituted with one to four Cd or Zn ions per protein molecule, followed by digestion with subtilisin, yielded increasing amounts of a proteolytically stable polypeptide fragment identical with the alpha fragment domain encompassing the four metal center. Samples renatured with five to seven Cd ions per MT molecule showed decreasing quantities of alpha fragment and increasing amounts of nativelike MT. The binding process in each domain is cooperative. Reconstitution of apo-MT with two Cd ions followed by proteolysis yields a 50% recovery of saturated Cd4-alpha cluster. Likewise, when Cd5-renatured MT was digested with subtilisin, 30% of the molecules were identified as Cd7-MT with the remainder as Cd4-alpha fragment.
Two methods for improved venous access in acute leukemia patients
Authors: J. C. Wade
Journal: JAMA (1981)

Arteriovenous fistulae and long-term indwelling right atrial (Hickman) catheters have been used as methods to improve venous access in patients with acute leukemia. The creation of 28 fistulae provided short duration of function (median, 12 days), with eight fistulae functioning less than 24 hours. Complications were negligible, and no increase in the incidence of bacteremia occurred. Fifty-one Hickman catheters have been placed, with a median placement granulocyte count of 335/μL. The median duration of function has been 91 days or more, with 19 still functioning and 25 other catheters functioning at the time of the patient's death. Complications have been minimal, with substantial postoperative hemorrhage occurring primarily in patients with active disseminated intravascular coagulopathy at the time of catheter placement. Catheter-associated infections were uncommon. The overall incidence of bacteremia was not increased in patients with Hickman catheters, and 28 of the 30 bacteremias that occurred while catheters were in place (three catheter associated) resolved without catheter removal. The Hickman catheter is a safe, reliable device for improvement of venous access in adult patients with acute leukemia. (<i>JAMA</i>1981;246:140-144)
<i>Notice to Readers</i>: New Web Location for Weekly and Annual NNDSS Data
Journal: MMWR Morbidity and Mortality Weekly Report (2018)

To improve the usability, availability, quality, and timeliness of surveillance data as part of the CDC Surveillance Strategy (1), CDC now provides users a convenient way to access notifiable infectious and noninfectious disease data through the National Notifiable Diseases Surveillance System (NNDSS) website.
Clarification of Reporting of Potential Conflicts of Interest
Authors: Neil Skolnik
Journal: JAMA (2019)

their best to know and implement the main recommendations in the guidelines.An ongoing trial, A Clinical Trial of Statin Therapy for Reducing Events in the Elderly (STAREE), is studying the effects of 40 mg of atorvastatin daily for primary prevention in 18 000 patients aged 70 years or older.Treatment with a statin is being compared with placebo on prolonging overall survival or disability-free survival. 4 Hopefully this trial will provide information regarding the effect of statins on older adults.Until such evidence becomes available, the clearest and most accurate way to phrase a recommendation for older adults might have been, "In adults 75 years of age and older, the effectiveness of initiating a moderate-intensity statin for primary prevention is not well established."
Myocardial metabolism and nitric oxide production in human failing heart using I-123 BMIPP scintigraphy Nishio Mayu, Sinsuke Nanto, Tomoki Ohara, Junichi Kotani, Tetuya Watanabe, Masashi Fujita, Masaki Awata, Syuichiroh Higo, Seiki Nagata. kansai rosai hospital, amagasaki, Japan
Journal: Journal of the American College of Cardiology (2001)
Spinal Injuries
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Naval Medicine
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE CONTROL OF THE PYLORUS
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reply
Authors: D. Mitchell, S. E. Tolfree, M. Short, M. Solomon, S. Spiro
Journal: Thorax (1988)

Effect of particle size of bronchodilator aerosols on lung distribution and pulmonary function in patients with chronic asthma SIR,-We feel that we must comment on the recent paper by Dr DM Mitchell and others (June 1987;42:457-61), since its findings are likely to be misinterpreted by many readers.Dr Mitchell and his colleagues nebulised salbutamol as aerosols of particles with mass median aerodynamic diameters (MMADs) of 1 4 and 5 5 jim in eight patients with chronic and severe stable asthma.On the basis of their data from previous radioaerosol deposition studies, they set out deliberately to deliver the same amount of drug to the lungs for each of the two aerosols, and found no difference in bronchodilator response.Although their methods were sound and their paper is of scientific interest, the study bears little relation to the clinical circumstances in which a fixed dose is placed in whatever nebuliser comes to hand and then nebulised "to dryness."Nebulisers differ widely in their droplet MMADs-from I to 12 jim-and hence in the amounts of drug able to penetrate the oropharynx and reach the lungs.We have compared two commonly used nebulisers, producing particles with an MMAD of 3 3 and 7 7 jm respectively: almost three times more radioaerosol was deposited in the lungs with the smaller aerosol and in a cumulative dose-response study using salbutamol bronchodilatation was significantly greater.'The use of the CIS-Optimist system seems a curious choice of nebuliser as this unit was designed to produce fine aerosols for ventilation scanning and achieves this by filtering out a very high proportion of the dose before it gets to the patient.Thus it would not be an ideal system for bronchodilator
Networking erythropoiesis
Authors: Marc A. Kerenyi, Stuart H. Orkin
Journal: The Journal of Experimental Medicine (2010)

A relatively small cadre of lineage-restricted transcription factors largely orchestrates erythropoiesis, but how these nuclear factors interact to regulate this complex biology is still largely unknown. However, recent technological advances, such as chromatin immunoprecipitation (ChIP) paired with massively parallel sequencing (ChIP-seq), gene expression profiling, and comprehensive bioinformatic analyses, offer new insights into the intricacies of red cell molecular circuits.
Treating <i>Helicobacter pylori</i> Infection May Improve Anemia
Journal: Annals of Internal Medicine (1999)

Summaries for Patients2 November 1999Treating Helicobacter pylori Infection May Improve AnemiaSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-131-9-199911020-00037 SectionsAboutFull Text ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Infection with Helicobacter pylori, a bacterium, can cause gastritis (irritation of the stomach lining) and stomach ulcers (areas of erosion of the stomach lining). Helicobacter pylori infection has also been associated with iron deficiency anemia (low blood counts due to low iron levels). Treating this infection heals the stomach lining. We do not know whether treatment improves anemia.Why did the researchers do this particular study?The researchers wanted to see if treating Helicobacter pylori infection in people with gastritis and iron deficiency anemia would improve the anemia.... Author, Article, and Disclosure InformationThe summary below is from the full report titled “Reversal of Iron Deficiency Anemia after Helicobacter pylori Eradication in Patients with Asymptomatic Gastritis.” It is in the 2 November 1999 issue of Annals of Internal Medicine (volume 131, pages 668-672). The authors are B. Annibale, M. Marignani, B. Monarca, G. Antonelli, A. Marcheggiano, G. Martino, F. Mandelli, R. Caprilli, and G. Delle Fave.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine. Previousarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoReversal of Iron Deficiency Anemia after Helicobacter pylori Eradication in Patients with Asymptomatic Gastritis Bruno Annibale , Massimo Marignani , Bruno Monarca , Giorgio Antonelli , Adriana Marcheggiano , Gina Martino , Franco Mandelli , Renzo Caprilli , and Gianfranco Delle Fave Metrics 2 November 1999Volume 131, Issue 9Page: 668KeywordsAnemiaBlood countsGastric ulcersGastritisHelicobacter pyloriHelicobacter pylori infectionIron deficiency anemiaPatientsStomach ePublished: 15 August 2000 Issue Published: 2 November 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.Loading ...