tbuckley/cabot-search huggingface dataset:
PURE FOOD WELL COOKED
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hydatidiform Mole
Authors: Harrison W. Pratt
Journal: JAMA (1975)

<h3>To the Editor.—</h3> The article by Pour-Reza et al fails to present data that substantiate their conclusion that hypoproteinemia favors the occurrence of hydatidiform mole. The documentation of hypoproteinemia concurrent with hydatidiform mole is not sufficient evidence of a causal relationship, nor is it sufficient evidence of premorbid hypoproteinemia. Ambulatory clinic patients and hospitalized preoperative patients are mismatched with respect to the significant postural changes in plasma water concentration. An increase of as much as 17% in total serum protein concentration may be observed as a subject changes from recumbency to the erect posture. This is due to hemoconcentration as plasma water moves into the interstitial space.<sup>1(p177)</sup> Pour-Reza et al report a mean total serum protein concentration 19.5% greater in the clinic population compared to the hospitalized population. If concentration changes due to recumbency were eliminated, the total protein difference between the groups might be of less statistical or
ACANTHOSIS NIGRICANS
Journal: JAMA (1960)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Qualifications for administrative medicine: is an MD enough?
Authors: D. M. Shlian
Journal: JAMA (1993)

<h3>In Reply.</h3> —I agree with and share Dr Amann's concerns over the massive debt burden of resident physicians. However, I disagree with his premise that the results of the grass roots campaign only pacify current residents and medical students, while neglecting those who will follow. Early versions of the reauthorization of the HEA eliminated deferment and limited forbearance to 3 years. Lobbying by the AMA and other groups, coupled with a major grass roots campaign by residents, medical students, senior physicians, and the AMA Auxiliary, led to the reinstitution of forbearance for the duration of residency and deferment for those residents who can prove need. The people who contacted their congressional representatives were working to retain the best possible outcome for all residents, current and future. Through their hard work and dedication to the profession, they influenced a government that wanted to severely limit repayment options for medical residents. The
Saeed Ahmad Khan Bernard Hugh Pentney Harry Munro Archibald Roger Cooper Francis Thomas ("Frank") Doleman Malvina ("Malca") Harris Muwaffak Abdul Hussain Andrew Waring Jowett Richard Baillie ("Dick") Laidlaw Frances Elizabeth O'Connor-Wilson (nee O'Connor) Thomas Richardson Alfred Sands ("Alf") Rogen Thomas Edward Tasker Pauline Jane Watson
Journal: BMJ (1997)
Children and Childhoods
Authors: Jane Green Schaller
Journal: JAMA (1992)

We have grown accustomed to wars and to measuring the casualties of wars as body counts of soldiers or tabulations of strategic buildings, military installations, or targets that have been destroyed. But there are other hidden casualties that are rarely considered: children and childhoods. Articles in recent editions ofTHE JOURNALand American Medical Association (AMA) specialty journals document the threats of domestic and societal violence to children growing up in "peaceful" countries such as the United States.<sup>1-4</sup>A number of articles in this issue ofThe JOURNALconsider another form of violence—war. The consequences of war have changed since World War I, when the estimated number of civilians killed by direct warfare ranged from 5% to 19%.<sup>5-9</sup>By World War II, estimations of the proportion of civilians killed during war had risen to 48% to 50%.<sup>5-9</sup>In the more than 150 declared and undeclared wars since
Avertin: Disclaimer
Authors: F. E. Shipway
Journal: BMJ (1933)

Promoting oligodendrocyte (OL) differentiation represents a promising option for remyelination therapy for treating the demyelinating disease multiple sclerosis (MS). The Wnt effector transcription factor 7-like 2 (TCF7l2) was upregulated in MS lesions and had been proposed to inhibit OL differentiation. Recent data suggest the opposite yet underlying mechanisms remain elusive. Here, we unravel a previously unappreciated function of TCF7l2 in controlling autocrine bone morphogenetic protein (BMP)4-mediated signaling. Disrupting TCF7l2 in mice of both sexes results in oligodendroglial-specific BMP4 upregulation and canonical BMP4 signaling activation <i>in vivo</i>. Mechanistically, TCF7l2 binds to <i>Bmp4</i> gene regulatory element and directly represses its transcriptional activity. Functionally, enforced TCF7l2 expression promotes OL differentiation by reducing autocrine BMP4 secretion and dampening BMP4 signaling. Importantly, compound genetic disruption demonstrates that oligodendroglial-specific BMP4 deletion rescues arrested OL differentiation elicited by TCF7l2 disruption <i>in vivo</i>. Collectively, our study reveals a novel connection between TCF7l2 and BMP4 in oligodendroglial lineage and provides new insights into augmenting TCF7l2 for promoting remyelination in demyelinating disorders such as MS. <b>SIGNIFICANCE STATEMENT</b> Incomplete or failed myelin repairs, primarily resulting from the arrested differentiation of myelin-forming oligodendrocytes (OLs) from oligodendroglial progenitor cells, is one of the major reasons for neurologic progression in people affected by multiple sclerosis (MS). Using <i>in vitro</i> culture systems and <i>in vivo</i> animal models, this study unraveled a previously unrecognized autocrine regulation of bone morphogenetic protein (BMP)4-mediated signaling by the Wnt effector transcription factor 7-like 2 (TCF7l2). We showed for the first time that TCF7l2 promotes oligodendroglial differentiation by repressing BMP4-mediated activity, which is dysregulated in MS lesions. Our study suggests that elevating TCF7l2 expression may be possible in overcoming arrested oligodendroglial differentiation as observed in MS patients.
?Genomic bi-focals? and a panoramic view of evolutionEvolution: From Molecules to Ecosystems edited by Andres Moya and Enrique Font. Oxford University Press, 2004. E75.00/E37.50 hbk/pbk (xvi+321 pages) ISBN 0 19 851542 1/0 19 851543 X
Authors: R SINGH
Journal: Trends in Ecology & Evolution (2004)
Skin pigmentation in Wilson's disease
Authors: M. L. Leu
Journal: JAMA (1970)

Twelve of 20 patients (60%) with Wilson's disease (hepatolenticular degeneration) were noted to have hyperpigmentation on the anterior aspect of the lower part of the legs. Histologically, this was found to be caused by increased melanin deposition. Copper and iron content in skin biopsy specimens was not different from that in controls.
Contents
Authors: Olivia Farr, Denise Sloan, Terence Keane, Christos Mantzoros, Liya Wu, Klaus Parhofer, Anastasia Dede, Symeon Tournis, Ismene Dontas, George Trovas, Gabriel Chiu, Gregory Freund, Rogério Antônio, Laurato Sertié, Andréa Sertié, Gisele Giannocco, Lourenço Leonice, Maria Poyares, Yi-Le Wu, Cai-Yun Hu, Shan-Shan Lu, Feng-Feng Gong, Fang Feng, Zhen-Zhong Qian, Xiu-Xiu Ding, Hui-Yun Yang, Ye-Huan Sun, Inga Schlecht, Philipp Wiggermann, Gundula Behrens, Beate Fischer, Manja Koch, Johanna Freese, Diana Rubin, Ute Nöthlings, Christian Stroszczynski, Michael Leitzmann, Diaozhu Lin, Kan Sun, Feng Li, Yiqin Qi, Meng Ren, Chulin Huang, Juying Tang, Shengneng Xue, Yan Li, Li Yan, Stephen Burns, Sojung Lee, Fida Bacha, Hala Tfayli, Tamara Hannon, Silva Arslanian, Maysa Vieira De Sousa, Rosa Pereira, Rosa Fukui, Valéria Caparbo, Maria Rossi Da Silva, Alexander Wree, Martin Schlattjan, Lars Bechmann, Thierry Claudel, Jan-Peter Sowa, Tatjana Stojakovic, Hubert Scharnagl, Harald Köfeler, Hideo Baba, Guido Gerken, Ariel Feldstein, Michael Trauner, Ali Canbay, Marinos Fysekidis, Emmanuel Cosson, Isabela Banu, Régine Duteil, Chantal Cyrille, Paul Valensi, Demidmaa Tuvdendorj, David Chinkes, John Bahadorani, Xiao-Jun Zhang, Melinda Sheffield-Moore, Lois Killewich, Robert Wolfe, Bilal Omar, Maria Sörhede-Winzell, Bo Ahrén, Aaron Mull, Tirsit Berhanu, Nathan Roberts, Ahlke Heydemann
Journal: Metabolism (2014)
Abstracts From the NCCN 22nd Annual Conference: Improving the Quality, Effectiveness, and Efficiency of Cancer Care™
Journal: Journal of the National Comprehensive Cancer Network (2017)

Background: Oral mucositis (OM) is a debilitating side effect of chemotherapy and radiotherapy (RT) in patients receiving myeloablative conditioning before stem cell transplantation (SCT).OM may result in opiate use, need for total parenteral nutrition (TPN), secondary infections, decreased quality of life, and reduction/interruption of therapy, ultimately compromising outcomes and increasing costs.Magic mouthwash (MMW) is frequently used for OM despite recommendations against its use due to limited efficacy and adverse effects, including dysgeusia, numbness, burning, or aspiration.Gelclair (GEL) is a well-tolerated, alcohol-free, bioadherent, oral/topical gel containing polyvinylpyrrolidone, sodium-hyaluronate, and glycyrrhetinic acid (from licorice root) broadly indicated for the management of oral lesions, including OM. Promising results on pain control and reductions in analgesics, incidence/severity of OM, and infection have been reported in patients receiving chemotherapy and RT.Additional randomized controlled trials with a relevant active comparator could support these positive findings.Methods: The purpose of this blinded, randomized, controlled trial in SCT recipients receiving myeloablative conditioning is to determine the impact of GEL versus MMW/standard of care (SOC), when initiated during conditioning or after OM is noted, following a standardized oral care protocol.Subjects will be randomized (1:1:1) to initiate GEL for up to 28 days on conditioning day 1 or after diagnosis of grade 1 OM versus MMW or SOC.A blinded clinician will conduct daily assessments and determine the incidence, time to onset, and duration of any or severe OM; overall mouth/throat pain; duration of effect; healthcare resources utilized; and subject burden associated with OM, such as number of treatments per day, opiate use, TPN, infection, and impact on activities of daily living.Results: New hypothesis-generating analyses of existing data sets show that in patients with chemotherapy-and RT-induced OM, by 3 and 5 hours posttreatment, only 10% and 35% of GEL patients required a second dose versus 27% and 58% of MMW patients, respectively (P=.037 or P=.034, respectively), suggesting that GEL controls OM-related pain longer than MMW.Conclusions: GEL controlled chemotherapy-and RT-induced OM symptoms longer than MMW, and the randomized/blinded study under development at leading US cancer centers will address the impact of GEL on the incidence and severity of OM and its related symptoms, complications, and costs in SCT recipients receiving myeloablative conditioning relative to SOC.
Global Handwashing Day — October 15, 2015
Authors: Kristen Gray, Eduardo Valverde, Tian Tang, Azfar-E-Alam Siddiqi, ; Hall, Thomas Frieden, Harold Jaffe, Joanne Cono, Chesley Richards, Michael Iademarco, Sonja Rasmussen, Charlotte Kent, Jacqueline Gindler, Teresa Rutledge, Douglas Weatherwax, Soumya Dunworth, Teresa Hood, Jude Rutledge, Martha Boyd, Maureen Leahy, Julia Martinroe, Stephen Spriggs, Brian Wood, Moua Yang, Quang Doan, Phyllis King, Teresa Moreland, Terraye Starr, Timothy Jones, Matthew Boulton, Virginia Caine, Katherine Daniel, Jonathan Fielding, David Fleming, William Halperin, King Holmes, Robin Ikeda, Rima Khabbaz, Phyllis Meadows, Jewel Mullen, Jeff Niederdeppe, Patricia Quinlisk, Patrick Remington, Carlos Roig, William Roper, William Schaffner, Regina Simeone, Brigette Gleason, John Redd, Peter Kilmarx, Tom Sesay, Francis Bayor, Antons Mozalevskis, Allison Connolly, James Akpablie, Dimitri Prybylski, Daphne Moffett, Michael King, Micah Bass, Kristy Joseph, Jefferson Jones, Francis Ocen, Amelia Kasper, Amanda Kamali
Journal: MMWR Morbidity and Mortality Weekly Report (2015)

National Latino AIDS Awareness Day is observed each year on October 15 to focus on the continuing and disproportionate impact of human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS) on the Hispanic or Latino population in the United States.Hispanics or Latinos represent approximately 17% of the U.S. population (1); however, in 2013, they accounted for 21% of all new diagnoses, corresponding to a rate of 18.7 per 100,000 (2).In 2011, an estimated 242,000 Hispanics or Latinos were living with HIV infection in the United States, representing 20% of all such persons.Of these Hispanics or Latinos, an estimated 85% had received a diagnosis of HIV infection, 40% were engaged in HIV medical care, 37% had received a prescription for antiretroviral therapy, and 31% had achieved viral suppression (3).National Latino AIDS Awareness Day is an opportunity to encourage increased HIV prevention activities, such as HIV testing, for Hispanics or Latinos.CDC supports testing, linkage to and engagement in care and treatment, and a range of other efforts to reduce the risk for acquiring or transmitting HIV infection among Hispanics or Latinos.Additional information about CDC resources and activities for National Latino AIDS Awareness Day is available at http://www.cdc.gov/Features/LatinoAIDSAwareness.Additional information about HIV among Hispanics or Latinos is available at http:// www.cdc.gov/hiv/risk/racialethnic/hispanicslatinos.Hispanics or Latinos* represent about 17% of the total U.S. population and are disproportionately affected by human immunodeficiency virus (HIV) infection in the United States (1,2).In 2013, the rate of HIV diagnosis among Hispanics or Latinos (18.7) was nearly three times that of non-Hispanic * Hispanics or Latinos can be of any race.
Antoni Van LEEUWENHOEK (1632-1723)
Journal: Annals of the Rheumatic Diseases (1994)

management of lupus.Although none of these drugs has been as thoroughly studied as cyclophosphamide, there is no evidence to suggest that any of them approaches the efficacy observed with cyclophosphamide.The anti- malarial hydroxychloroquine has come to assume a promi- nent role in the therapy of most lupus patients, albeit with some concern as to whether it can ever be safely dis- continued.9There is a large clinical experience with low dose, daily azathioprine and, because of its more reassuring record of safety, many physicians continue to use this drug instead of cyclophosphamide.There is much less clinical experience with drugs such as low dose, weekly methotrexate'0 or cyclosporin," but available evidence would seem to suggest a role for these drugs in moderately active disease.Improvements in the therapy of lupus will require continued investments in clinical trials of the disease.Among the more promising interventions in immediate prospect are new nucleoside analogues that have a prolonged effect on immune function,'2 androgenic steroids,'3 and biological products.'4It seems reasonable to assume these may have a clinical impact in lupus therapy in the very near future.However, perhaps of far greater importance, are possible therapeutic approaches that would correct the fundamental immune abnormalities responsible for lupus.In particular, the induction of immune tolerance to autoantigens, as has been attempted in studies of patients with rheumatoid arthritis'5 or multiple sclerosis,'6 would seem to be a highly worthy subject for future clinical investigation.Moreover, it is not too premature to begin consideration of reconstitution of the immune system by bone marrow transplantation'7 or, ultimately, selective gene therapy.Basic and clinical studies have begun the search for candidate genes associated with autoimmunity, 820 but considerably more work will be required before clinical protocols for gene therapy of the disease can be developed.
Abstract 3174: A novel prognostic model for tongue squamous cell carcinoma based on the characteristics of tumor and its microenvironment: iBD score
Authors: Xiqiang Liu
Journal: Cancer Research (2019)

Abstract Aims: Tumor budding and invasive depth can predict survival of patients with tongue squamous cell carcinoma (TSCC), while the prognostic value of tumor microenvironment (TME) remains unknown. Here, both characteristics of tumor and its microenvironment were examined and a novel prognostic model has been proposed. Methods: A total of 246 patients with TSCC were included. Using H&amp;E stained sections, pathological parameters of tumor and the TME were assessed. Inflammatory response (i), tumor budding (B), and invasive depth (D) were combined as iBD score. The association between these variables and the patient survival was determined. Results: Both tumor budding and inflammatory status were independent variables for predicting overall survival (OS) and disease-free survival (DFS) of TSCC patients. Invasive depth was correlated with differentiation, T classification, lymph node metastasis, clinical stage, and recurrence (P&amp;lt; 0.05). The novel iBD model was strongly correlated with T classification, lymph node metastasis, clinical stage, and recurrence, and showed clear distinction of score 0, 1 and 2. High iBD score had a strong association with reduced OS and DFS (P&amp;lt; 0.01). Conclusions: iBD scoring model is strongly associated with lymph node metastasis and recurrence in TSCC and could be a promising survival predictor for TSCC patients. Note: This abstract was not presented at the meeting. Citation Format: Xiqiang Liu. A novel prognostic model for tongue squamous cell carcinoma based on the characteristics of tumor and its microenvironment: iBD score [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3174.
DOMESTIC ABSTRACTS
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
"BOTULISM DUE TO OLIVES"
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal