tbuckley/cabot-search huggingface dataset:
MILK ADULTERATION.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Normal Bacterial Populations of the Intestine and Their Relation to Intestinal Function
Authors: Robert M. Donaldson
Journal: New England Journal of Medicine (1964)

IN the latter part of the nineteenth century discovery of the bacterial basis for many diseases, together with dramatic demonstrations of the potency of bacterial toxins, led to the concept of intestinal autointoxication. Vociferously championed by Metchnikoff,1 this theory held that noxious intestinal bacterial products were absorbed and were the cause of many of man's afflictions. Although widely accepted at first, the autointoxication concept received little or no support in the form of sound experimental data and was soon exploited by quacks and faddists. Indeed, scientific reaction against the theory may well have impeded subsequent objective investigation into the physiologic . . .
US Adults Are Lax on Meeting National Exercise Guidelines
Journal: JAMA (2013)

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Humanity
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Letter: A place to be born.
Authors: D Chamberlain, R Fulton, K Green, N Hamer, M Oliver, B Pentecost
Journal: BMJ (1976)

permissible but obligatory?This technique identified factors which each independently was associated with special benefit-namely, a pre-entry history of anterior infarction and below-average blood pressure at entry.In our paper we discussed collateral evidence, and adduced reasons, for believing that patients with anterior infarction are at special risk from late serious arrhythmias.We understand less well the apparent importance of 5-blockade to patients with lower diastolic blood pressures, but it would not be justifiable to ignore statistically significant trial results.Finally, we are puzzled by the authors' reluctance in their last paragraph to accept the arguments that the life-saving effects were due to ~-adrenoceptor blockade rather than to any property peculiar to practolol.Indeed, in the first sentences of their second paragraph they claim that the results obtained using practolol confirm the results of their own small-scale trial with alprenolol.1 With this we agree.
THE FATE OF PATHOGENIC BACTERIA IN BURIED CADAVERS.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pramipexole vs Levodopa as Initial Treatment for Parkinson Disease
Authors: None Parkinson Study Group
Journal: JAMA (2000)

ContextPramipexole and levodopa both ameliorate the motor symptoms of early Parkinson disease (PD), but no controlled studies have compared long-term outcomes after initiating dopaminergic therapy with pramipexole vs levodopa.ObjectiveTo compare the development of dopaminergic motor complications after initial treatment of early PD with pramipexole vs levodopa.DesignMulticenter, parallel-group, double-blind, randomized controlled trial.SettingAcademic movement disorders clinics at 22 sites in the United States and Canada.PatientsThree hundred one patients with early PD who required dopaminergic therapy to treat emerging disability, enrolled between October 1996 and August 1997.InterventionsSubjects were randomly assigned to receive pramipexole, 0.5 mg 3 times per day, with levodopa placebo (n = 151); or carbidopa/levodopa, 25/100 mg 3 times per day, with pramipexole placebo (n = 150). For patients with residual disability, the dosage was escalated during the first 10 weeks. From week 11 to month 23.5, investigators were permitted to add open-label levodopa to treat continuing or emerging disability.Main Outcome MeasuresTime to the first occurrence of any of 3 dopaminergic complications: wearing off, dyskinesias, or on-off motor fluctuations; changes in scores on the Unified Parkinson's Disease Rating Scale (UPDRS), assessed at baseline and follow-up evaluations; and, in a subgroup of 82 subjects evaluated at baseline and 23.5 months, ratio of specific to nondisplaceable striatal iodine 123 2-β-carboxymethoxy-3-β-(4-iodophenyl)tropane (β-CIT) uptake on single photon emission computed tomography imaging of the dopamine transporter.ResultsInitial pramipexole treatment resulted in significantly less development of wearing off, dyskinesias, or on-off motor fluctuations (28%) compared with levodopa (51%) (hazard ratio, 0.45; 95% confidence interval [CI], 0.30-0.66; P&lt;.001). The mean improvement in total UPDRS score from baseline to 23.5 months was greater in the levodopa group than in the pramipexole group (9.2 vs 4.5 points; P&lt;.001). Somnolence was more common in pramipexole-treated patients than in levodopa-treated patients (32.4% vs 17.3%; P = .003), and the difference was seen during the escalation phase of treatment. In the subgroup study, patients treated initially with pramipexole (n = 39) showed a mean (SD) decline of 20.0% (14.2%) in striatal β-CIT uptake compared with a 24.8% (14.4%) decline in subjects treated initially with levodopa (n = 39; P = .15).ConclusionsFewer patients receiving initial treatment for PD with pramipexole developed dopaminergic motor complications than with levodopa therapy. Despite supplementation with open-label levodopa in both groups, the levodopa-treated group had a greater improvement in total UPDRS compared with the pramipexole group.
A GMCSF &amp; IL15 Fusokine Leads to Paradoxical Immunosuppression In Vivo Via Asymmetrical JAK/STAT Signalling through the IL15 Receptor Complex.
Authors: Moutih Rafei, Jian Hui Wu, Borhane Annabi, Laurence Lejeune, Moira Francois, Jacques Galipeau
Journal: Blood (2006)
CORRECTION
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Distribution of inducible nitric oxide synthase in liver tissue after liver transplantation , M Burkhard, T. Goeser, J.C. Arnold, W. Stremmel, L. Theilmann. Department ofGastroenterology, Medical Clinic, University of Heidelberg, Heidelberg, Germany
Journal: Hepatology (1995)

The early management of the cardiovascular dysfunction of septic shock is critical as it is associated with a poor outcome. Although the use of catecholamines is a common therapy in this syndrome, no data are available on the involvement of β-adrenoceptor (β-AR) subtypes and only few studies report an alteration of β-adrenergic-induced vasodilation in septic shock. The purpose of the study was to evaluate vascular β1, β2 and β3-AR expression and function in an endotoxemic rat model.Endotoxemia was induced in rats by intravenous injection of lipopolysaccharide (LPS). β1, β2 and β3-AR mRNA expression was evaluated by RT-PCR in aorta and vascular β1, β2 and β3-AR responses were determined on conducting (aorta) and/or resistance (mesenteric and renal) arteries by constructing relaxation curves in response to different β-AR agonists.The maximal effect of isoproterenol decreased by 31 to 61% in the three vascular beds of LPS-treated rats compared to controls. In aortas from LPS-treated rats, β1 and β3-AR mRNA expression was decreased and associated to a reduced β1 and β3-induced vasodilation. Conversely, albeit β2-AR mRNA was unchanged, the maximal β2-AR-induced vasodilation increased by 49% in aortas from LPS-treated rats compared to controls. This increase was not affected by endothelium removal but was abolished in the presence of a β2-AR antagonist or an adenylate cyclase inhibitor.In endotoxemia, β2-AR vasodilation was increased by a potential recruitment of β2-AR located on smooth muscle cells. This study suggests that vascular β2-AR should be a putative new therapeutic target in septic shock.
Sundowning
Authors: Jane Sasser
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Platelets facilitate the wound-healing capability of mesenchymal stem cells by mitochondrial transfer and metabolic reprogramming
Authors: Jennyfer Levoux, Alexandre Prola, Peggy Lafuste, Marianne Gervais, Nathalie Chevallier, Zeynab Koumaiha, Kaouthar Kefi, Laura Braud, Alain Schmitt, Azzedine Yacia, Aurélie Schirmann, Barbara Hersant, Mounia Sid-Ahmed, Sabrina Ben Larbi, Katerina Komrskova, Jakub Rohlena, Frederic Relaix, Jiri Neuzil, Anne-Marie Rodriguez
Journal: Cell Metabolism (2021)
AUROTHERAPY IN RHEUMATOID ARTHRITIS
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Failure to diagnose acute myocardial infarction. The clinicopathologic experience at a large community hospital
Authors: E. J. Zarling
Journal: JAMA (1983)

A retrospective study of 100 consecutive cases of autopsy-proved acute myocardial infarction has disclosed a surprisingly low frequency (53%) of correct antemortem diagnoses. Incorrect diagnoses seemed to be caused by (1) unjustified dependence on misleading laboratory studies, (2) inattention to suggestive or diagnostic laboratory studies, (3) atypical or obscure presentation of myocardial infarction, and (4) failure to consider acute myocardial infarction as a diagnostic possibility, particularly when the responsible physician was not a specialist in internal medicine or its subspecialty of cardiology. Suggested corrective measures are a more appropriate use of the ECG and the laboratory and education and reeducation of selected groups of physicians. (<i>JAMA</i>1983;250:1177-1181)
Correction
Authors: Raymond Oliphant, Philip Mcloone, David Morrison, Raymond Mr, Deepak Bhasin, S Rana, Kartar Singh
Journal: Gut (2011)

screening invitation, is difficult due to the confounding effect that deprivation has on both background life expectancy 3 and colorectal cancer screening participation. 4 As a result, any potential benefit of screening in terms of later age at death cannot be adequately assessed from this analysis.
<i>Announcement</i>: National Campaign to Prevent Falls in Construction — United States, May 2–6, 2016
Journal: MMWR Morbidity and Mortality Weekly Report (2016)

The National Safety Stand-Down to Prevent Falls in Construction* will be observed May 2-6, 2016, and is hosted by the federal Occupational Safety and Health Administration and stakeholders, including CDC's National Institute for Occupational Safety and Health. During the voluntary stand-down, construction employers are asked to speak directly to their employees about fall hazards to reinforce the importance of adhering to fall prevention measures. Employers are encouraged to have a Spanish speaker deliver the stand-down message to Spanish-speaking employees (simultaneous translation is an alternative). Across the United States, state agencies, public health practitioners, and private contractors will promote participation in the event.
Destabilization of the Postsynaptic Density by PSD-95 Serine 73 Phosphorylation Inhibits Spine Growth and Synaptic Plasticity
Authors: Pascal Steiner, Michael J. Higley, Weifeng Xu, Brian L. Czervionke, Robert C. Malenka, Bernardo L. Sabatini
Journal: Neuron (2009)
Atresia of the Small Intestine Produced by Intussusception<i>In Utero</i>
Authors: Gherardo J. Gherardi, John H. Fisher
Journal: New England Journal of Medicine (1961)

IMPAIRMENT of the vascular supply to a segment of bowel may be one of a number of causes of intestinal atresia. Louw§ and others have been persuasive in demonstrating that local ischemia probably underlies most such events and that vascular occlusive phenomena may result from accidental derangements during intra-uterine life. Kinks in bowel loops, adhesive bands, volvulus and other similar mechanical alterations may be responsible for most of these accidents. Less commonly, intussusception in utero has a dominant role in the pathogenesis. The following case illustrates this situation.Case ReportA 3-day-old male infant was referred to the Boston Floating . . .
Endoplasmic Reticulum Stress Is a Target for Therapy in Waldenstrom’s Macroglobulinemia (WM).
Authors: Xavier Leleu, Lian Xu, Zachary R. Hunter, Xiaoying Jia, Anne-Sophie Moreau, Allen W. Ho, Evdoxia Hatjiharissi, Hai N’Go, Daniel D. Santos, Kelly O’Connor, Robert Manning, Jacob Soumerai, Christopher Patterson, Irene M. Ghobrial, Steven P. Treon
Journal: Blood (2006)
Bedside tracer gas technique accurately predicts outcome in aspiration of spontaneous pneumothorax
Authors: D G Kiely, S Ansari, W A Davey, V Mahadevan, G J Taylor, D Seaton
Journal: Thorax (2001)

BACKGROUND There is no technique in general use that reliably predicts the outcome of manual aspiration of spontaneous pneumothorax. We have hypothesised that the absence of a pleural leak at the time of aspiration will identify a group of patients in whom immediate discharge is unlikely to be complicated by early lung re-collapse and have tested this hypothesis by using a simple bedside tracer gas technique. METHODS Eighty four episodes of primary spontaneous pneumothorax and 35 episodes of secondary spontaneous pneumothorax were studied prospectively. Patients breathed air containing a tracer (propellant gas from a pressurised metered dose inhaler) while the pneumothorax was aspirated percutaneously. Tracer gas in the aspirate was detected at the bedside using a portable flame ioniser and episodes were categorised as tracer gas positive (&gt;1 part per million of tracer gas) or negative. The presence of tracer gas was taken to imply a persistent pleural leak. Failure of manual aspiration and the need for a further intervention was based on chest radiographic appearances showing either failure of the lung to re-expand or re-collapse following initial re-expansion. RESULTS A negative tracer gas test alone implied that manual aspiration would be successful in the treatment of 93% of episodes of primary spontaneous pneumothorax (p&lt;0.001) and in 86% of episodes of secondary spontaneous pneumothorax (p=0.01). A positive test implied that manual aspiration would either fail to re-expand the lung or that early re-collapse would occur despite initial re-expansion in 66% of episodes of primary spontaneous pneumothorax and 71% of episodes of secondary spontaneous pneumothorax. Lung re-inflation on the chest radiograph taken immediately after aspiration was a poor predictor of successful aspiration, with lung re-collapse occurring in 34% of episodes by the following day such that a further intervention was required. CONCLUSIONS National guidelines currently recommend immediate discharge of patients with primary spontaneous pneumothorax based primarily on the outcome of the post-aspiration chest radiograph which we have shown to be a poor predictor of early lung re-collapse. Using a simple bedside test in combination with the post-aspiration chest radiograph, we can predict with high accuracy the success of aspiration in achieving sustained lung re-inflation, thereby identifying patients with primary spontaneous pneumothorax who can be safely and immediately discharged home and those who should be observed overnight because of a significant risk of re-collapse, with an estimated re-admission rate of 1%.