tbuckley/cabot-search huggingface dataset:
Effects of Cigarette Smoking on Metabolic Events in the Lung
Authors: Satoshi Kitamura
Journal: Environmental Health Perspectives (1987)

Nicotine and cigarette smoke extract show acute physiological effects: increasing tracheal pressure (PTR), pulmonary artery pressure (PPA), systemic blood pressure (PSYST), and left atrium pressure (PLA); and decreasing cardiac output (QAORTA) and blood flow to the left lower lobe (QLLL). In addition, cigarette smoking induces bronchoconstriction, thus decreasing peak flow, FVC, and FEV1.0 in healthy subjects. It has also been demonstrated that cigarette smoking caused temporary slowing of mucociliary clearance in the lung and that cigarette smoke increases the activity of aryl hydrocarbon hydroxylase which metabolizes benzo[alpha]pyrene. We demonstrated that serum angiotensin I converting enzyme (ACE) activity showed a significant increase immediately after smoking and returned to the control level 20 min after smoking. We also demonstrated that plasma histamine levels showed a marked decrease after smoking. Furthermore, the effects of cigarette smoke and related substances on prostaglandin, thromboxane, testosterone, cyclic nucleotides metabolism, and protein synthesis were also investigated.
Extended phase I trial of the oral pan-Bcl-2 inhibitor AT-101 by multiple dosing schedules in patients with advanced cancers
Authors: H. C. Pitot, M. Saleh, J. Holmlund, J. Maleski, A. Forero
Journal: Journal of Clinical Oncology (2007)

3583 Background: Over-expression of Bcl-2 family proteins is common in human cancers. Initial trials of the oral pan-Bcl-2 inhibitor AT-101 showed acute dose limiting toxicity of Gr 3–4 AST/ALT (MTD 40 mg/d), and ileus with prolonged dosing daily (QD) for 21/28 days per cycle (Saleh, NCI_EORTC, 2005; James, ASCO, 2006). Our ongoing Phase 1 study tests different dosing schedules of AT-101 in adults with advanced cancers. Methods: Serial patient (pt) cohorts received AT-101 at escalating doses twice a day for three days every other week (BIDx3dEOW) or once weekly (QW). Adverse events (AEs) were graded by the NCI CTCAE v. 3.0. Results: 24 pts have received pulse dosing; safety data are available for 20 pts (30–70 mg BIDx3dEOW, N=13; 80–160 mg QW, N=7). For comparison, 38 pts received 5–60 mg QD. Median number of cycles (range): BIDx3dEOW_2(1–9); QW_3(1–3), QD_2(1–12). AST/ALT is not yet dose limiting, nor the MTD reached, at 70 mg BIDx3dEOW or 160 mg QW. Ileus occurred in 4/38 pts dosed daily but in no pts on either pulse schedule. Other potentially related Gr 3–4 AEs were: BIDx3dEOW (6 pts)–AST (1 pt), abdominal pain (2 pts), elevated CK/right ventricular dysfunction (1 pt w/history of COPD/doxil therapy), hypokalemia (1 pt);QW: none; QD: AST/ALT (5 pts), nausea/vomiting/diarrhea (3 pts each) fatigue (2 pts), hypocalcemia (2 pts), hypokalaemia/anorexia/dehydration/hypophosphatemia (1 pt), elevated GGT (1 pt). The most common Gr 1–2 AEs_nausea/vomiting/fatigue_occurred in over 50% of QD and BIDx3dEOW pts but only 1/7 QW pts. Plasma C max (mean ± SD, μM): 70 mg BIDx3d EOW, 2.4 ± 0.9; 160 mg QW, 3.5 ± 1.3; 40 mg/d (MTD, 21/28 d), 2.6 ± 2.0. T ½ was approx. 3 hours on all schedules. Conclusions: Pulse dosing of AT-101 appears associated with reduced toxicity than more continuous daily dosing, and may be preferable in combination regimens. No significant financial relationships to disclose.
Medical education in the United States. II. Undergraduate medical education. Approved medical schools
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Re: Agrawal et al.: Collaborative Ocular Tuberculosis Study consensus guidelines on the management of tubercular uveitis–report 1: Guidelines for initiating antitubercular therapy in tubercular choroiditis (Ophthalmology. 2020 Jan 11;S0161-6420(20)30013-0. https://doi.org/10.1016/j.ophtha.2020.01.008 [Epub ahead of print])
Authors: Pradeep Venkatesh, Rohan Chawla, Vinod Kumar
Journal: Ophthalmology (2020)
Contents
Authors: R Moschen, J Goldwasser, P Cohen, W Lin, D Kitsberg, P Balaguer, S Polyak, R Chung, M Yarmush, Y Nahmias, C Patients Gane, R Rouzier, C Stedman, A Wiercinska-Drapalo, A Horban, L Chang, Y Zhang, P Sampeur, I Nájera, P Smith, N Shulman, J Tran, B Haagmans, A Soulier, C Ferrari, G Missale, S Zeuzem, J.-M Pawlotsky, S Schalm, K Hellstrand, A Neumann, M Lagging, P Deltenre, M Corouge, V Canva, H Castel, F Wartel, S Dharancy, A Louvet, M Lazrek, C Moreno, J Henrion, P Mathurin, S Lucifora, D Arzberger, L Durantel, M Belloni, M Strubin, F Levrero, O Zoulim, U Hantz, Sion Kim, M Cho, S Baik, H Park, H Jeon, C Im, C Won, J Kim, H Kim, S Kwon, S Eom, Y Cha, S Kim, S Chang
Journal: Journal of Hepatology (2011)
Error in Abstract
Journal: JAMA Oncology (2019)

Fiamma Berner, MSc; David Bomze, MSc; Stefan Diem, MD; Omar Hasan Ali, MD; Mirjam Fässler, MD; Sandra Ring, MSc; Rebekka Niederer, MD; Christoph J. Ackermann, MD; Petra Baumgaertner, MSc; Natalia Pikor, PhD; Cristina Gil Cruz, PhD; Willem van de Veen, PhD; Mübeccel Akdis, MD, PhD; Sergey Nikolaev, PhD; Heinz Läubli, MD, PhD; Alfred Zippelius, MD; Fabienne Hartmann, MSc; Hung-Wei Cheng, PhD; Gideon Hönger, MSc; Mike Recher, MD; Jonathan Goldman, MD; Antonio Cozzio, MD; Martin Früh, MD; Jacques Neefjes, PhD; Christoph Driessen, MD; Burkhard Ludewig, DVM; Ahmed N. Hegazy, MD, PhD; Wolfram Jochum, MD; Daniel E. Speiser, MD; Lukas Flatz, MD
A new oral hypoglycemic agent. Tolazamide (Tolinase)
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PMO-170 Prevalence of hepatitis E in New York among HIV negative chronic liver disease population “is it an innocent bystander”
Authors: P Basu, T Nair, S Farhat, M Jafri, K Mittimani, N James Shah, L Ang
Journal: Gut (2012)

<h3>Introduction</h3> Hepatitis E is essentially an oral fecal infection with high prevalence in developing countries. There is limited data available on its prevalence in Urban US. The study evaluates the prevalence of hepatitis E antibody IgG and IgM in New York in patients with chronic liver disease. <h3>Methods</h3> 440 (n=440) were divided into two groups: group A; control 140 patients without any stigmata of liver disease. Group B, 300 patients with history of liver disease including hepatitis B 125/300 (41%), Chronic hepatitis C 60/300 (20%), fatty liver 70/300 (23%), Alcoholic liver disease 29/300 (10%), HBV HCV co infection 9/300 (3%), auto immune hepatitis 2/300 (0.6%), PBC /PSC 5/300 (2%). HEV antibody IGM and IGG were measured with HEV genotyping. 22/300 (7%) patients were liver transplant recipients, 6/300 (2%) patients were kidney transplant recipients. 43/300 (14%) patients were Intra venous Drug Abuser. 20/300 (7%) received Blood products. <h3>Results</h3> History and genotypic characteristics <h3>Conclusion</h3> <b>Results</b>: Group (A) HEV IgG positive 13% (18/140), Group B HEV IgG positive 40.6% (122/300) including 3.7% (4/122) having both IgM and IgG positive. The prevalence of HEV IgG was 54% (12/22) in the liver transplant recipient group and 33% (2/6%) kidney transplant recipient group. The study demonstrates the prevalence of hepatitis E infection in New York and HEV antibody in CLD. Including transplant donors and recipients. Question remains the impact and progression of acute or chronic liver disease with concomitant HEV in pre, peri, and post liver transplant recipient. Larger study needs to validate. <h3>Competing interests</h3> None declared.
Health Care Needs of a Homosexual Population
Journal: JAMA (1982)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Contents
Authors: P Burra, F Tacke, V Ratziu, S Zeuzem, B Sangro, P Angeli, Y Kupriyanova, O Zaharia, P Bobrov, Y Karusheva, V Burkart, J Szendroedi, J.-H Hwang, M Roden, T Wang, K Chen, W Yao, R Zheng, Q He, J Xia, J Li, Y Shao, L Zhang, L Huang, L Qin, M Xu, Z.-Z Zhang, D Pan, Z Li, F Huang, L Krassenburg, R Maan, A Ramji, M Manns, M Cornberg, H Wedemeyer, R De Knegt, B Hansen, H Janssen, R De Man, J Feld, A Van Der Meer, M García-López, S Lens, L Pallett, B Testoni, S Rodríguez-Tajes, Z Mariño, C Bartres, E García-Pras, T Leonel, E Perpiñán, J Lozano, F Rodríguez-Frías, G Koutsoudakis, F Zoulim, M Maini, X Forns, S Pérez-Del-Pulgar, N Higashi-Kuwata, S Hayashi, H Kumamoto, H Ogata-Aoki, D Das, D Venzon, S.-I Hattori, H Bulut, M Hashimoto, M Otagiri, N Takamune, N Kishimoto, D Davis, S Misumi, M Kakuni, Y Tanaka, H Mitsuya, T Vasavan, S Deepak, I Jayawardane, M Lucchini, C Martin, V Geenes, J Yang, A Lövgren-Sandblom, P Seed, J Chambers, S Stone, L Kurlak, P Dixon, H.-U Marschall, J Gorelik, L Chappell, P Loughna, J Thornton, F Pipkin, B Hayes-Gill, W Fifer, C Williamson, J Trebicka, J Fernandez, M Papp, P Caraceni, W Laleman, C Gambino, I Giovo, F Uschner, C Jansen, C Jimenez, R Mookerjee, T Gustot, A Albillos, R Bañares, P Jarcuska, C Steib, T Reiberger, J Acevedo, P Gatti, D Shawcross, A Zipprich, S Piano, T Berg, T Bruns, K Danielsen, M Coenraad, M Merli, R Stauber, H Zoller, J Ramos, C Solé, G Soriano, A De Gottardi, H Gronbaek, F Saliba, C Trautwein, H Kani, S Francque, S Ryder, P Nahon, M Romero-Gomez, H Van Vlierberghe, C Francoz, E Garcia-Lopez, M Tufoni, A Amoros, M Pavesi, C Sanchez, M Praktiknjo, A Curto, C Pitarch, A Putignano, E Moreno, W Bernal, F Aguilar, J Clària, P Ponzo, Z Vitalis, G Zaccherini, B Balogh, A Gerbes, V Vargas, C Alessandria, M Bernardi, P Ginès, R Moreau, R Jalan, V Arroyo, R Morikawa, N Nakamoto, T Amiya, P.-S Chu, Y Koda, T Teratani, T Suzuki, Y Kurebayashi, A Ueno, N Taniki, K Miyamoto, A Yamaguchi, S Shiba, T Katayama, K Yoshida, Y Takada, R Ishihara, H Ebinuma, M Sakamoto, T Kanai, S.-T Cheng, J.-L Hu, J.-H Ren, H.-B Yu, S Zhong, V Wong, B Kwan Law, W.-X Chen, H.-M Xu, X.-F Cai, Y Hu, W.- L Zhang, Q.-X Long, F Ren, H.-Z Zhou, A.-L Huang, J Chen, J Howell, A Pedrana, S Schroeder, N Scott, L Aufegger, R Atun, R Baptista-Leite, G Hirnschall, E 't Hoen, S Hutchinson, J Lazarus, L Olufunmilayo, R Peck, M Sharma, A Sohn, A Thompson, M Thursz, D Wilson, M Hellard, S.-Y Cai, D Yu, C Soroka, J Wang, J Boyer, D Chand, F Mohr, H Mcmillan, F Tukov, K Montgomery, A Kleyn, R Sun, S Tauscher-Wisniewski, P Kaufmann, G Kullak-Ublick, T Marjot, A Moon, J Cook, S Abd-Elsalam, C Aloman, M Armstrong, E Pose, E Brenner, T Cargill, M.-A Catana, R Dhanasekaran, A Eshraghian, I García-Juárez, U Gill, P Jones, J Kennedy, A Marshall, C Matthews, G Mells, C Mercer, P Perumalswami, E Avitabile, X Qi, F Su, N Ufere, Y Wong, M.-H Zheng, E Barnes, A Barritt, G Webb
Journal: Journal of Hepatology (2021)
Rationing intensive care
Authors: J. C. Moskop
Journal: JAMA (1994)

<h3>In Reply.</h3> —We believe it is not necessarily discriminatory to consider age as a contributing factor in ICU triage for several reasons. First, if one takes an "over-the-life-span" perspective, the young and the old are at different time points in a common life experience and should develop a shared perspective about the best care for individuals at different times in the life cycle. From this shared perspective, the most appropriate medical care may vary with age. Second, even if one does not agree with this ethical view, empirical evidence shows that chronological age is a determinant of prognosis for critically ill patients.<sup>2</sup>Third, if one takes a cost-benefit perspective, even when a young individual and an old individual have the same diagnosis, severity of illness, functional status, and probability of ICU survival, statistically the younger individual will likely have a longer period of benefit than the older individual. On
Houston Heart Pump...
Journal: JAMA (1966)

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Massachusetts Medical Society
Authors: John Figgis Jewett
Journal: New England Journal of Medicine (1959)

STATEMENT OF PRINCIPLES GOVERNING CERTAIN PHYSICIAN-LAWYER RELATIONSHIPS*The advantages to be derived from good relations between the medical and legal professions are obvious. The following Statement of Principles is intended to outline the general framework for doctor-lawyer relations. It has been prepared by a joint committee representing the Massachusetts Medical Society, the Massachusetts Bar Association and the Boston Bar Association and has been approved by the Executive Committee of the Massachusetts Bar Association and the councils of the Boston Bar Association and the Massachusetts Medical Society. It incorporates the best features of other similar statements, and adapts them to local . . .
Cosmetic management of nevi
Authors: O. C. Stegmaier
Journal: JAMA (1967)

Since nevi are the most prevalent of all skin tumors and since many are situated on the face, patients frequently request their removal for cosmetic reasons. A brief clinicopathologic description of the life cycle of the nevus<sup>1</sup>will be presented first as a guide to the physician in the cosmetic management of nevi. The description presented here applies only to white skins and may or may not be applicable to other races. The method of removing nevi for cosmetic reasons will then be presented. This discussion of nevi is limited to those arising from nevus cells and does not include other birthmarks, such as hemangiomas, which are sometimes called nevi. <h3>Life Cycle of the Nevus</h3> The pigmented nevus (nevus cell nevus, or common mole) is peculiar to man and is the most common neoplasm found in humans. Everyone has a few nevi somewhere on his body; most persons age
Anticoagulant therapy
Authors: Edward A. Edwards
Journal: JAMA (1962)

This very carefully written book on anticoagulants should prove to be a most valuable reference work. Two chapters are devoted to the history of the discovery and development of heparin, and bishydroxycoumarin ( Dicumarol) and its allies, and another to a short discussion of other anticoagulants. There are then chapters on the coagulation mechanism, the mechanism of thrombus production, and fibrinolysis. The action of the anticoagulant drugs is thoroughly explained, their chemistry and pharmacology are presented in great detail, and laboratory tests for their control are carefully described. An extensive list of references appears at the end of each chapter. The author, who is a physician, goes into the clinical use of these drugs in some detail. It is rather surprising to find that he offers very few uses for heparin, mentioning mainly its use in vascular and cardiac surgery and in instances of acute peripheral artery obstruction. Only parenthetically, in
Allen's Commercial Organic Analysis. A Treatise on the Properties, Modes of Analysis, and Proximate Analytical Examination of the Various Organic Chemicals and Products Employed in the Arts, Manufactures, Medicine, etc. With Concise Methods for the Detection and Estimation of Their Impurities, Adulterations, and Products of Decomposition.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Influence of Thyroid Hormone Analogues on Isotransplanted Spontaneous Mammary Adenocarcinoma in Mice
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Iowa Wrestling Study
Authors: Charles M. Tipton
Journal: JAMA (1970)

Changes in body weight were measured in 747 wrestlers from 30 Iowa high schools. During a 17-day period before certification, the average weight loss was 6.8 lb (3.1 kg) or 4.9% of the initial body weight, with most of these changes occurring during the final ten days. Questionnaire results indicated that the coach and the "other wrestler" were the most frequently consulted on how to "make weight" whereas the local physician was seldom consulted on this matter. Comparison of weight gains after the end of the season showed that the average increase was 13.6 lb (6.2 kg) higher than the weight at certification. Until more information is available that is specific for this age group, it is our opinion that medical supervision be provided when wrestlers have lost 7% to 10% of their initial weight or are losing weight in excess of 4 lb (1.8 kg) per week.