tbuckley/cabot-search huggingface dataset:
Acyanotic Levocardia
Authors: HAROLD D. ROSENBAUM, EDMUND D. PELLEGRINO, LEO J. TRECIOKAS
Journal: Circulation (1962)

Three cases of acyanotic levocardia are reported. One case was associated with congenitally corrected transposition and arterial AV valve insufficiency. The precise nature of the heart disease in the second case has not been determined, and the last case was without known cardiac disease. Attention is drawn to a serious lack of an accepted terminology in describing cases with spatial derangements of the heart or its chambers as well as incomplete data in published reports concerning the relative positions and internal anatomy of the chambers of the heart, its peripheral connections, and the disposition of the abdominal viscera. It is probable many more individuals with levocardia without heart disease, or with acyanotic heart disease, exist than is suggested by the current medical literature.
Obituaries
Journal: JAMA (1980)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Osteoporosis Among Estrogen-Deficient Women—United States, 1988-1994
Journal: JAMA (1999)

Each year in the United States, hip fractures result in approximately 300,000 hospital admissions and an estimated $9 billion in direct medical costs. Most of these fractures result from osteoporosis among women who experience accelerated bone loss after natural or surgically induced menopause. Measurement of bone mineral density (BMD) is the best tool available to assess osteoporotic fracture risk for women after menopause; a reduction of one standard deviation (SD) in femoral BMD is comparable to a 14-year increase in age on the risk for hip fracture. A technology that allows highly accurate and precise measurement of BMD is dual energy x-ray absorptiometry (DXA). CDC's Third National Health and Nutrition Examination Survey (NHANES III) was the first nationally representative survey that used DXA to estimate osteoporosis prevalence based on BMD in the U.S. population, providing baseline information for assessing national prevention and intervention needs for this disease. This report compares self-reported health information with BMD measurements from NHANES III conducted during 1988-1994; the findings indicate that most estrogen-deficient women in the United States who had femoral osteoporosis based on BMD were unaware of having this condition, reflecting the evolving nature of research and clinical practice regarding osteoporosis.
Immunohistochemical phenotyping of liver macrophages in normal and diseased human liver
Authors: M Tomita
Journal: Hepatology (1994)

The phenotypical heterogeneity of human liver macrophages was analyzed with monoclonal antibodies that recognize antigens specific for the monocytemacrophage lineage. Most liver macrophages in normal and diseased liver were positive for CD68, whereas fewer matured macrophages were detected by 25–F9. Comparative staining of mirror sections revealed some to be doubly positive and others to be singly CD68 positive. Quantitative analysis confirmed the difference, suggesting heterogeneity of maturation in liver macrophages. Most liver macrophages in the normal liver were negative for CD14, a receptor for lipopolysaccharide and lipopolysaccharide-binding protein complexes. Liver macrophages in liver diseases were activated to express CD14 at varying degrees and were involved in the clearance of lipopolysaccharide-lipopolysaccharide-binding protein complexes. FcγRI, a receptor for monomeric IgG that is involved in antibody-mediated cell cytotoxicity, was negative in the normal liver, but was expressed in liver macrophages at inflammatory sites (e.g., in piecemeal and focal necrosis) in diseased livers. FcγRII was expressed in most liver macrophages, as well as in sinusoidal endothelial cells; FcγRIII was expressed in a smaller number of liver macrophages. Expression of FcγRIII and FcγRIII was increased in chronic active hepatitis. These results suggest that liver macrophages are heterogeneous in maturation and function and that they are activated in liver diseases as shown by the novel expression of CD14 and FcγRI. The restricted expression of FcγRI indicates that FcγRI-positive macrophages, in cooperation with cytotoxic T lymphocytes, may play an important role in liver cell injury through antibody-mediated cell cytotoxicity. (Hepatology 1994;20:317–325.)
Predictive modelling to identify and characterize fast progressors among patients with non-alcoholic steatohepatitis (NASH)
Authors: Brenda Reinhart, Matt Docherty, Maria Magdalena Balp, Stephane Régnier, Andreas Tietz, Jennifer Cai, Sanchita Porwal, Marcos Pedrosa, Jörn M. Schattenberg
Journal: Journal of Hepatology (2020)
CORRECTION: TREASURER'S/EDITOR'S TELEPHONE NUMBER
Journal: British Journal of Sports Medicine (1977)

rudiments of sports medicine.The annual BASM/FIMS course is not enough, nor is the annual meeting of the Chartered Physiotherapists in Sports Medicine; these are only pilot schemes, enjoyable and instructive as they undoubtably are.We need much more effort, not just for national events, but also for local organisation.In this issue there is a letter from Dr. J. W. Walker, trying to enlist support for a new area in Berkshire and surrounding counties.
"Suramin Blockade of Insulinlike Growth Factor I-Stimulated Proliferation of Human Osteosarcoma Cells"
Authors: M. Pollak, M. Richard
Journal: JNCI Journal of the National Cancer Institute (1990)

Erratum: In figure 3A on page 1350 of the report “Suramin Blockade of Insulinlike Growth Factor I-Stimulated Proliferation of Human Osteosarcoma Cells” by M. Pollak and M. Richard (vol 82:1349–1352,1990), there was an error in symbol identification. The points on the control curve should be represented by open circles, and the points on the IGF-I curve should be represented by filled circles.
Case History
Authors: Jack Coulehan
Journal: JAMA (2009)

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Understanding MeSH for Literature Searches
Authors: S. J. Darmoni
Journal: JAMA (1995)

<h3>To the Editor.</h3> —The article by Drs Lowe and Barnett<sup>1</sup>is helpful in understanding and using the MeSH vocabulary. We read with particular interest the description of "Publication Types" and "MeSH Subheadings." Unfortunately, the definition and the list of check tags are incomplete. The definition of check tags should specify that this group of MESH terms is mandatory: for example, all citations dealing with the concept of pregnancy must be indexed with the corresponding check tag "PREGNANCY," even if, in some cases, there is a more precise heading such as "PREGNANCY COMPLICATIONS" or "ABORTION." Of the 10 check tags listed in Table 3 by Lowe and Barnett<sup>1</sup>that are check tags only, the exhaustive list of check tags must include the terms that are also headings (Table). This list was established with the MeSH vocabulary file, which specifies in the Annotation field for each heading if it is
THE ORIGINAL OF MULTIPLE LIPOMAS.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Continuing Medical Education
Authors: Arthur M. Osteen
Journal: JAMA (1988)

<h3>ACCREDITATION ACTIVITIES</h3> In 1987 the Accreditation Council for Continuing Medical Education (ACCME) adopted a monitoring procedure to strengthen the continuing medical education (CME) accreditation process. Recognizing that the ACCME Review Committee plays a pivotal role in the accreditation process by evaluating applicants and by recommending accreditation actions to the Council, the ACCME decided to monitor the work of the Review Committee more closely as a method of quality assurance. The procedure directs that two ACCME representatives attend each meeting of the Review Committee as observers and prepare formal reports to the ACCME on how effectively the Review Committee conducts the reverse-site interviews, evaluates the applicants, and develops the accreditation recommendations. Accreditation of CME is a collaborative effort of ACCME on the national level and state medical societies on the state level. It is assumed that sponsors accredited by state medical societies design their activities for physicians within the state or
Massive catecholamine release from caffeine poisoning
Authors: N. L. Benowitz
Journal: JAMA (1982)

CAFFEINE is widely consumed both in beverages such as coffee, tea, or cola soft drinks and in over-the-counter anorectic, stimulant, diuretic, and analgesic drugs. The sympathomimetic effects of caffeine are well known and are believed to result from inhibition of phosphodiesterase, an enzyme that degrades the β-adrenergic messenger, cyclic adenosine monophosphate. Recently, it was shown that caffeine in doses that might be consumed in beverages increases plasma catecholamine concentrations.<sup>1</sup>We have observed a patient who took a suicidal overdose of caffeine and had a hyperadrenergic syndrome associated with markedly elevated circulating catecholamine concentrations. <h3>Report of a Case</h3> A 30-year-old woman was found on the floor of her room, acting bizarrely. She had a history of bipolar affective illness with hypomanic behavior and hallucinations. For several days, she had been obsessed with the idea that her body was ridden with cancer, which led to her ingestion of four bottles of
Elucidation of the thromboregulatory role of CD39/ectoapyrase in the ischemic brain
Authors: David J. Pinsky, M. Johan Broekman, Jacques J. Peschon, Kim L. Stocking, Tomoyuki Fujita, Ravichandran Ramasamy, E. Sander Connolly, Judy Huang, Szilard Kiss, Yuan Zhang, Tanvir F. Choudhri, Ryan A. McTaggart, Hui Liao, Joan H.F. Drosopoulos, Virginia L. Price, Aaron J. Marcus, Charles R. Maliszewski
Journal: Journal of Clinical Investigation (2002)

Endothelial CD39 metabolizes ADP released from activated platelets. Recombinant soluble human CD39 (solCD39) potently inhibited ex vivo platelet aggregation in response to ADP and reduced cerebral infarct volumes in mice following transient middle cerebral artery occlusion, even when given 3 hours after stroke. Postischemic platelet and fibrin deposition were decreased and perfusion increased without increasing intracerebral hemorrhage. In contrast, aspirin did not increase postischemic blood flow or reduce infarction volume, but did increase intracerebral hemorrhage. Mice lacking the enzymatically active extracellular portion of the CD39 molecule were generated by replacement of exons 4–6 (apyrase-conserved regions 2–4) with a PGKneo cassette. Although CD39 mRNA 3′ of the neomycin cassette insertion site was detected, brains from these mice lacked both apyrase activity and CD39 immunoreactivity. Although their baseline phenotype, hematological profiles, and bleeding times were normal, cd39–/– mice exhibited increased cerebral infarct volumes and reduced postischemic perfusion. solCD39 reconstituted these mice, restoring postischemic cerebral perfusion and rescuing them from cerebral injury. These data demonstrate that CD39 exerts a protective thromboregulatory function in stroke.
Studies on the Uptake, Metabolism, and Release of Endogenous and Exogenous Chemicals by Use of the Isolated Perfused Lung
Authors: M. W. Anderson, T. E. Eling
Journal: Environmental Health Perspectives (1976)

The isolated perfused lung is a valuable tool for studying many lung functions. The kinds of information one can obtain from the isolated perfused lung are illustrated by examples from our studies on the uptake, accumulation, and metabolism of endogenous and exogenous chemicals.
Type 2 Diabetes
Authors: Jennifer F. Wilson
Journal: Annals of Internal Medicine (2007)

It is nearly impossible to be a practicing internist in the United States and have a day of clinical work pass without encountering at least 1 patient with type 2 diabetes. Currently, over 20 million Americans and over 150 million worldwide have type 2 diabetes. Models estimate that this number will nearly double by the year 2050 so that about one third of adult Americans will have the disease. This In the Clinic feature includes answers to these and other practical, clinical questions... What are the diagnostic criteria for type 2 diabetes in nonpregnant adults? Should we screen for type 2 diabetes? Can we prevent type 2 diabetes? What should the initial evaluation of patients with newly diagnosed type 2 diabetes include? What measures do U.S. stakeholders use to evaluate the quality of care for patients with type 2 diabetes? Only ACP members and individual subscribers can access the electronic features of In the Clinic. Non-subscribers who wish to access this issue of In the Clinic can elect "Pay for View." Subscribers can receive 1.5 category 1 CME credits by completing the CME quiz that accompanies this issue of In the Clinic. The content of In the Clinic is drawn from the clinical information and education resources of the American College of Physicians (ACP), including PIER (Physicians' Information and Education Resource) and MKSAP (Medical Knowledge and Self Assessment Program). Annals of Internal Medicine editors develop In the Clinic from these primary sources in collaboration with the ACP's Medical Education and Publishing division and with assistance of science writers and physician writers. Editorial consultants from PIER and MKSAP provide expert review of the content. Readers who are interested in these primary resources for more detail can consult www.acponline.org, http://pier.acponline.org, and other resources referenced within each issue of In the Clinic.
JAMA Journal Club
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hospice effectiveness in controlling pain
Authors: R. L. Kane
Journal: JAMA (1985)

Terminal cancer patients were randomly assigned to receive comprehensive hospice care or traditional medical care. Patients were followed up for two years or until death. Pain was measured by the McGill Pain Scale. Frequency and intensity of cancer-related symptoms were also noted. Over the course of the study, 34% of hospice patients and 21% of control patients never reported pain. No significant differences between the two groups could be detected in either the proportion of patients with pain at any time or the intensity of pain. Neither were there differences in the intensity or frequency of cancer-related symptoms. The presence of pain was associated with the presence of other symptoms; a significant correlation was found between the levels of depression and anxiety and pain scores. (<i>JAMA</i>1985;253:2683-2686)
Bovine somatotropin supplementation of dairy cows. Is the milk safe?
Authors: W. H. Daughaday
Journal: JAMA (1990)

Complex, biologically active proteins (eg, enzymes and hormones) can be manufactured safely and cost-effectively through applications of biotechnology. Some of these proteins (eg, human insulin, human somatotropin, rennet for cheese manufacture) are currently approved for medical or food processing applications. Bovine somatotropin (bST) for lactating dairy cattle is another product that can be produced via biotechnology and may allow dairy farmers to produce milk at a lower cost. In 1985, based on an evaluation of toxicological data, the Food and Drug Administration concluded that milk and meat from bST-supplemented cows was safe and wholesome. The Food and Drug Administration has authorized the use of milk and meat from bST-supplemented cows in the commercial food supply. Its evaluation of the impact of bST supplementation on the long-term health of dairy cattle is near completion, and bST may be approved for commercial use in early 1991. (<i>JAMA</i>. 1990;264:1003-1005)
THE ABDOMINAL INJURIES OF WARFARE--I
Authors: G. Gordon-Taylor
Journal: BMJ (1939)

Ever since " the dark backward and abysm of Time " the belly of an enemy has constituted an instinctive target, and the relative proximity of adversaries has in no small measure determined the incidence of abdominal wounds received in conflict.The vulnerability of the abdomen in the geological eras, when but a short space can have separated rival foemen, is attested in museums, where may be seen portions of the human lumbar spine with impaled flint arrow-heads; some of these relics embedded in the anterior portion of the vertebral bodies limn with unerring surety the transabdominal course of a missile shot long ages ago by some enemy hand of the Neolithic period, a dual monument to victor and to slain.
Paper electrophoresis
Authors: M. Lubran
Journal: JAMA (1966)

Electrophoresis is the movement of charged particles in solution under the influence of an external electrical field. Paper electrophoresis employs filter paper strips soaked in buffer solution, usually diethylbarbituric acid and barbituric acid dissolved in alkali (Veronal buffer), pH 8.6. A small volume of serum is placed on the paper and a direct current passed for several hours. The serum proteins separate into five zones, which can be made visible by staining with dyes. The protein migrating farthest is albumin; then, in order, come α<sub>1</sub>-, α<sub>2</sub>-, β-, and γ-globulin. Occasionally, the β zone is split into β<sub>1</sub>and β<sub>2</sub>zones. By use of a densitometer, the amount of dye in each zone may be measured and recorded as a tracing with peaks corresponding to each dyed zone (Fig 1).<sup>1</sup> <h3>Quantitation of Serum Proteins.—</h3> Paper electrophoresis provides only an approximate value for the serum proteins. Analysis