tbuckley/cabot-search huggingface dataset:
Abstract 282: A <i>Drosophila</i> Model of Cardiac Lipotoxicity
Authors: Bryon F Tuthill, Louis A Searcy, Richard A Yost, Laura P Musselman
Journal: Circulation Research (2017)

Obesity is associated with cardiovascular disease in humans and a number of model organisms, including the fruit fly Drosophila melanogaster . We use a fly model of high-sugar-diet-induced metabolic disease that includes hyperglycemia, insulin resistance, obesity, cardiovascular disease, and reduced longevity. High-sugar-fed flies accumulate lipids in a variety of organs, including the heart. We are using tissue-specific metabolomics and loss-of-function genetics to probe the roles of individual organs and lipids in cardiovascular disease. Our goal is to focus on conserved pathways to better understand how overnutrition with high-calorie diets leads to adverse outcomes in patients with complications of type 2 diabetes.
Clinical Disorders of Acid-Base Equilibrium
Authors: Saulo Klahr
Journal: JAMA (1968)

<h3>To the Editor:—</h3> Most clinical abnormalities of acid-base balance, other than those sustained abnormalities brought about by chronic lung or kidney disease, are short lived if adequately treated. At no point have we suggested that therapy is not indicated or required in most acid-base abnormalities. We agree with Dr. Tashima that the second sentence should have included a decrease as well as an increase in hydrogen ions, and a gain as well as an extracorporeal loss of base. However, in our subsequent description of the disturbances of acid-base equilibrium, the mechanisms responsible for these derangements are clearly enumerated. We did not suggest that the CO<sup>2</sup>content should be measured in a blood sample other than the one in which the pH and Pco<sup>2</sup>are measured. We simply stated that while it is customary to measure CO<sup>2</sup>content in venous blood, it is not at all satisfactory to
Inhibition of Aurora-Kinases for Tailored Risk-Adapted Treatment of Multiple Myeloma
Authors: Dirk Hose, Thierry Rème, Tobias Meißner, Jérôme Moreaux, Anja Seckinger, Joe Lewis, Vladimir Benes, Axel Benner, Michael Hundemer, Thomas Hielscher, John D. Shaughnessy, Bart Barlogie, Kai Neben, Alwin Krämer, Jens Hillengass, Uta Bertsch, Anna Jauch, John De Vos, Jean François Rossi, Thomas Möhler, Jonathon Blake, Jürgen Zimmermann, Bernard Klein, Hartmut Goldschmidt
Journal: Blood (2008)
Coronary heart disease mortality. A community perspective
Authors: M. Feinleib
Journal: JAMA (1972)

A mortality survey was taken in an affluent suburban Maryland community of 250,000. During calendar year 1969, there were 719 recorded deaths for persons aged 35 to 74 years, of which 257 (36%) were due to coronary heart disease (CHD). Fifty-four (21%) of the CHD deaths were certified as occurring elsewhere than in a hospital. One hundred eighty-seven CHD victims reached local medical facilities; of these, 101 (54%) were either dead on arrival or pronounced dead in emergency rooms. Thus, in a minimum of 155 instances or 60% of the total CHD mortality experience, the patients died before receiving definitive medical care. The median patient delay, from onset of symptoms until hospital arrival, for the 66 persons with fatal CHD who were hospitalized locally was 5.6 hours. Public education and mobile and other ancillary medical facilities play a role in reducing premature CHD mortality.
Factors influencing metabolism and toxicity of metals. Proceedings of an international workshop meeting organized by the Scientific Committee on the Toxicology of Metals of Permanent Commission and International Association of Occupational Health Stockholm, July 17-22, 1977.
Authors: Gunnar Nordberg, Bruce Fowler, Lars Friberg, Arne Jernelov, Norton Nelson, Magnus Piscator, Harold Sandstead, Jaroslav Vostal, Velimir Vouk
Journal: Environmental Health Perspectives (1978)
Circulating tumor cell (CTC) detection, N-terminal androgen (AR) characterization, and PTEN loss in metastatic or advanced castration resistant prostate cancer (CRPC).
Authors: Shidong Jia, Sarah Baird, Amanda Anderson, Shannon Werner, Jane Petersen, Ling Huw, Dena Marrinucci, Premal H. Patel
Journal: Journal of Clinical Oncology (2015)

e22034 Background: Detection and characterization of CTCs offers a minimally invasive mechanism for understanding patient response to therapy and disease evolution. Here we describe a proprietary technology platform to examine CTC incidence, N-terminal AR expression, and PTEN loss in metastatic or advanced CRPC patient samples from a phase II clinical trial (GO27983) testing the combination of the AKT inhibitor ipatasertib and abiraterone. Methods: Blood samples from CRPC patients (n = 283) were collected at screening and shipped to Epic Sciences. Upon receipt, the nucleated cells were plated onto microscope slides and stored at -80C. Two slides were thawed per patient and analyzed with an N-terminal AR CTC assay. CTCs were detected using a combination of CD45 exclusion, CK and N-terminal AR expression, and morphologic criteria. Traditional (CD45-, CK+, DAPI+) and Non-Traditional (CD45-/CK- with distinct morphology or CD45-/CK+ with fragmented nuclei) CTCs were enumerated and N-terminal AR expression was quantified for each CTC. Samples with > 2 Traditional CTCs enumerated per slide were further evaluated for PTEN loss by FISH (n = 170). Results: Traditional CTCs were detected ( ≥ 1 cell/ml) in 86% (242 of 283) of samples. Non-traditional CTCs were detected in 93% (263 of 283) of patients. N-terminal AR positivity was detected ( ≥ 1 AR+ cell/ml) in 53% (128 of 242) of Traditional CTC-positive samples, with the % positivity ranging from 0.4-100%. PTEN status was determined for 66% (160 of 243) of patients with Traditional CTCs detected. Patients with homozygous (HO) PTEN loss had a significantly higher mean CTC/mL (p = 0.0013) and AR+ CTC/mL value (p = 0.0014) than patients with PTEN non-deleted status. Conclusions: The ability of the Epic Sciences platform to detect AR+ CTCs and PTEN loss at screening provides a non-invasive approach to characterizing and monitoring CTCs identified in advanced CRPC patients. The phase II clinical trial is ongoing and we will continue to monitor longitudinal changes in CTC incidence and AR expression in relation to PTEN status.
Immunopathogenesis and therapy of cutaneous T cell lymphoma
Authors: E. J. Kim, S. Hess, S. K. Richardson, S. Newton, L. C. Showe, B. M. Benoit, R. Ubriani, C. C. Vittorio, J. M. Junkins-Hopkins, M. Wysocka, A. H. Rook
Journal: Journal of Clinical Investigation (2007)

During the preparation of the manuscript
THE PLAGUE IN CALIFORNIA.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical Investigations in Psychiatry
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
National Survey of Trauma Registries—United States, 1987
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
True Democracy
Authors: J. M. Alston
Journal: BMJ (1966)

A 77-year-old man was referred with a history of recurrent urinary tract infections and a raised prostate-specific antigen. He was found to have an atypical lesion of the urinary bladder on cystoscopic examination. A preoperative MRI study suggested no evidence of malignancy and histology was consistent with urinary bladder xanthoma. This is a benign and exceedingly rare condition which requires no further treatment or follow-up. Patients should, however, have a lipid profile measured. Our case illustrates the use of MRI as an adjunct to aid operative planning. Although not essential, it may help to avoid an over aggressive initial resection in more precarious areas of the urinary bladder.
Heterocyclic Amine-Induced Cancer and Myocardial Lesions in Nonhuman Primates
Authors: James S. Felton
Journal: Environmental Health Perspectives (1994)

The Sixth SenseIn his article, "Neurogenic Inflammation and Sensitivity to Environmental Chemicals" (101:234-238), Meggs speculates that neuropeptide mediators of inflammation may be responsible for sick building syn- drome and multiple chemical sensitivity syndrome (MCS).He invokes a novel sixth sense, the "common chemical sense," in the noses of such patients.Meggs's speculations greatly exceed the scientific knowledge of the functions of neuropeptides.He seems to accept that these clinical conditions actually exist, although he acknowledges that MCS "remains highly controversial."In fact, there is a substantial body of literature (1-) that these syndromes are largely psychogenic and are exploited by "alternative medicine" prac- titioners and quacks who ignore the distinction between speculation like Meggs's and proven fact, and who disregard the need for proof before clinical implementation.The American Medical Association Council on Scientific Affairs believes that multiple chemical sensitivity should not be considered a recognized clinical syndrome (JO).We appreciate Meggs's call for more scientific research into these matters.In the meantime, we hope he is not providing more grist for the quacks' mill.
Inconsistency in Missing Cases in Derivation Data and Validation Data
Authors: Kevin Swartout, Mary Koss, Jacquelyn White, Martie Thompson, Antonia Abbey, Alexandra Bellis
Journal: JAMA Pediatrics (2015)

Kevin M. Swartout, PhD; Mary P. Koss, PhD; Jacquelyn W. White, PhD; Martie P. Thompson, PhD; Antonia Abbey, PhD; Alexandra L. Bellis, BS
APPARATUS FOR COLLECTING CARBON DIOXID SNOW
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hormonal content of thyroid replacement preparations
Authors: R. W. Rees-Jones
Journal: JAMA (1980)

ACCORDING to present pharmaceutical industry estimates, there were 15 million prescriptions written in the last year for thyroid replacement in the United States. Of these, approximately 50% were for synthetic hormones, and the remainder were for preparations derived from animal sources. At present, both generic thyroid and levothyroxine preparations are available, and their use has been encouraged by recent changes in prescription regulations. Since the Food and Drug Administration still accepts the<i>United States Pharmacopeia</i>standard based on organic iodine content for this medication, there is no specification of the precise hormonal content of these tablets. This study reports the triiodothyronine (T<sub>3</sub>) and thyroxine (T<sub>4</sub>) content of a number of generic thyroid and T<sub>4</sub>preparations, using a radioimmunoassay.<sup>1</sup>This survey was occasioned by the experience of a patient who received a biologically ineffective thyroid tablet. <h3>Report of a Case</h3> A 54-year-old woman with primary hypothyroidism since
Incorrect Table Data in: Benefits and Harms of CT Screening for Lung Cancer: a Systematic Review
Journal: JAMA (2012)

Peter B. Bach, MD, MAPP; Joshua N. Mirkin, BA; Thomas K. Oliver, BA; Christopher G. Azzoli, MD; Donald A. Berry, PhD; Otis W. Brawley, MD; Tim Byers, MD, MPH; Graham A. Colditz, MD, DrPH; Michael K. Gould, MD, MS; James R. Jett, MD; Anita L. Sabichi, MD; Rebecca Smith-Bindman, MD; Douglas E. Wood, MD; Amir Qaseem, MD, PhD, MHA; Frank C. Detterbeck, MD
Mechanistic Relationship among Mutagenicity, Skin Sensitization, and Skin Carcinogenicity
Authors: John Ashby, Jennifer Hilton, Rebecca J. Dearman, Richard D. Callander, Ian Kimber
Journal: Environmental Health Perspectives (1993)

Twenty organic Salmonella mutagens, seven of which (including benzo[a]pyrene) are established skin carcinogens, and one of which (2-chloroethanol) is a well-defined noncarcinogen to skin, have been evaluated for skin-sensitizing activity using the local lymph node assay. The relative mutagenicity of the agents to Salmonella was also established. Fourteen of the chemicals were positive in the local lymph node assay, including the seven skin carcinogens. 2-Chloroethanol was inactive as a sensitizing agent. We suggest that a variety of factors contributes to the lack of sensitizing activity of the remaining six bacterial mutagens: extremes of intrinsic chemical reactivity, high water solubility reducing dermal translocation, and inappropriate dermal metabolism. Two reference skin-sensitizing agents (an oxazolinone and fluorescein isothiocyanate) were established as in vitro clastogens after their recognition as nonmutagens to Salmonella. These data imply that mutagenicity, rather than simply activity in the Salmonella assay, is a primary stimulus for electrophilic sensitization and carcinogenic initiation in the skin. We conclude that genotoxicity data for an agent can provide indications of the agent's potential to induce skin sensitization and that genotoxins which are skin-sensitizing agents have an enhanced potential to initiate skin carcinogenesis. We suggest that common, albeit individually distinct, structure-activity relationships underpin genotoxicity, skin sensitization, and the initiation of skin carcinogenesis. These relationships should simplify the hazard evaluation of chemicals and contribute to a reduction in animal usage. Several predictions of skin carcinogenicity are made based on the data presented.
Acknowledgment Omitted
Journal: JAMA (1983)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Macrophage Stimulation and the Inflammatory Response to Asbestos
Authors: J. A. Hamilton
Journal: Environmental Health Perspectives (1980)

Chrysotile fibers injected into the peritoneal cavity of mice elicit a cellular exudate. Macrophages appearing in this exudate produce high levels of the neutral protease, plasminogen activator, when compared with the resident peritoneal macrophage population. In contrast, the levels of lysozyme and two lysosomal enzymes are the same for the two macrophage types. The asbestos-induced macrophages producing the plasminogen activator appear to have descended from recently divided precursors. Low concentrations of anti-inflammatory glucocorticoids inhibit macrophage plasminogen activator synthesis. Preliminary experiments indicate that different asbestos types induce hyperemia in skin, and also shorten the partial thromboplastin time of plasma and generate the release of kinins. These observations could be interrelated and are suggested as representing some aspects of the inflammatory response of the host to asbestos exposure.
Abstract 1252: Intracellular iron chelation by a novel compound, C7, reactivates Epstein-Barr virus (EBV) lytic cycle via the ERK-autophagy axis in EBV-positive epithelial cancers
Authors: Alan K S Chiang, Stephanie PT Yiu, Kwai F. Hui, Chung K. Choi, Richard YT Kao, Dan Yang
Journal: Cancer Research (2019)

Abstract Pharmaceutical reactivation of lytic cycle of Epstein-Barr virus (EBV) represents a potential therapeutic strategy against EBV-associated epithelial malignancies e.g. gastric carcinoma (GC) and nasopharyngeal carcinoma (NPC). A novel lytic inducing compound, C7, which exhibits structural similarity to Dp44mT, a known chelator of intracellular iron, is found to reactivate EBV lytic cycle in GC and NPC. This study aims to investigate the role of intracellular iron chelation by C7 and other iron chelators in lytic reactivation of EBV in GC and NPC. Testing of 6 structural analogues of C7 revealed only those which had high affinity towards transition metals could induce EBV lytic cycle. Pre-complexing C7 and iron chelators to iron prior to treatment of the cells abolished EBV lytic reactivation. Though hypoxia signaling pathway was activated, it was not the only pathway associated with EBV reactivation. Specifically, C7 and iron chelators initiated autophagy by activating extracellular signal-regulated kinase (ERK1/2) to reactivate EBV lytic cycle since autophagy and EBV lytic reactivation were abolished in cells treated with ERK1/2 blockers whilst autophagy inhibition by 3-MA and ATG5 knockdown significantly abolished EBV lytic reactivation. In summary, we discover a novel mechanism of reactivation of EBV lytic cycle through intracellular iron chelation and induction of ERK-autophagy axis in EBV-positive epithelial malignancies, raising the question whether clinically available iron chelators can be combined with existing therapeutic modalities to treat these cancers. Note: This abstract was not presented at the meeting. Citation Format: Alan K S Chiang, Stephanie PT Yiu, Kwai F. Hui, Chung K. Choi, Richard YT Kao, Dan Yang. Intracellular iron chelation by a novel compound, C7, reactivates Epstein-Barr virus (EBV) lytic cycle via the ERK-autophagy axis in EBV-positive epithelial cancers [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1252.
Pneumonia and pneumonia related mortality in patients with COPD treated with fixed combinations of inhaled corticosteroid and long acting 2 agonist: observational matched cohort study (PATHOS)
Journal: BMJ (2013)

Pneumonia and pneumonia related mortality in patients with COPD treated with fixed combinations of inhaled corticosteroid and long acting β2 agonist: observational matched cohort study (PATHOS)Janson and colleagues have informed us of an error in the pico version of this Research paper, which is available online as the "Section PDF" and published in print (BMJ 2013;346:f3306, doi:10.1136/