tbuckley/cabot-search huggingface dataset:
Certain Styrene Oligomers Have Proliferative Activity on MCF-7 Human Breast Tumor Cells and Binding Affinity for Human Estrogen Receptor a
Authors: Ken-ichi Ohyama, Fumiko Nagai, Yoshiteru Tsuchiya
Journal: Environmental Health Perspectives (2001)

Polystyrene used for food containers, such as takeout food containers, coffee cups, meat trays, soup bowls, and salad boxes (1), contains high levels of styrene dimers (90-1,030 µg/g) and styrene trimers (650-20,770 µg/g) as impurities (2,3).These styrene oligomers migrate from the polystyrene containers into the containers' contents (4-6).When polystyrene containers containing vegetable oil were treated by heating in a microwave oven or were incubated for 24 hr at 20°C, a styrene dimer, 2,4-diphenyl-1-butene (SD-2; 0-1.6 ng/cm 2 ) and styrene trimers 2,4,6triphenyl-1-hexene (ST-1; 1.3-69.7 ng/cm 2 ), 1a-phenyl-4a-(1´-phenylethyl)tetralin (ST-2; 9.2-156 ng/cm 2 ), 1a-phenyl-4e-(1´-phenylethyl)tetralin (ST-3; 18.1-501 ng/cm 2 ), 1ephenyl-4a-(1´-phenylethyl)tetralin (ST-4; 13.9-294 ng/cm 2 ), and 1e-phenyl-4e-(1´phenylethyl)tetralin (ST-5; 18.7-306 ng/cm 2 ) migrated into the vegetable oil (4).When instant foods such as Chinese noodles, Japanese noodles, buckwheat noodles, chow mein, spaghetti, and rice were packed in polystyrene containers, styrene trimers ST-1 (0-8.1 µg/cup), ST-2 + ST-3 (0-13.8µg/cup), ST-4 (0-5.2 µg/cup), and ST-5 (0-8.4 µg/cup) migrated (0-33.8µg total styrene oligomers detected in a cup) from the containers into the foods after cooking in the cups, but the dimers did not (5).The maximum quantity of styrene trimers that migrated from containers to foods was higher than that of bisphenol A leached from the lacquer coating of vegetable cans (4-23 µg/can) (7).Colborn et al. ( 8) designated styrene dimers and trimers as endocrine disrupters in the Wingspread statement, and the Environmental Agency, Government of Japan, cited styrene dimers and trimers as compounds suspected of having endocrinedisruptive effects in its Strategic Programs on Environmental Endocrine Disrupters (9).However, styrene oligomers were reported to have no endocrine disruptive effect both in a MCF-7 cell proliferation assay (10) and in a radioisotope (RI) receptor competitive-binding assay using rat estrogen receptor (10,11).Therefore, we tested 11 styrene oligomers including those found in food (4,5) in a proliferation assay at an optimal initial cell concentration using human breast tumor, highly estrogen-sensitive MCF-7 cells.We also examined the binding potency of these styrene oligomers to human estrogen receptor α (hERα) in a non-RI receptor competitivebinding assay.
THAT ORANGE-COLORED SLIP
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mammography and Clinical Breast Examinations Among Women Aged 50 Years and Older— Behavioral Risk Factor Surveillance System, 1992
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis
Authors: Zuoning Han, David L. Boyle, Lufen Chang, Brydon Bennett, Michael Karin, Li Yang, Anthony M. Manning, Gary S. Firestein
Journal: Journal of Clinical Investigation (2001)

An error was introduced into Figure 1 during production of the article.The corrected figure, accompanied by the legend, appears below.Additionally, the GAPDH portion of Figure 4 was mislabeled, and equal loading of RNA in each lane of this experiment was demonstrated in the ethidium-stained gel.
Consultations of Children Living near Open-Cast Coal Mines
Authors: Denise Howel, Tanja Pless-Mulloli, Ross Darnell
Journal: Environmental Health Perspectives (2001)

Because of local concerns, general practitioner consultation rates in children living in communities close to and away from open-cast mines were compared. Information on consultations was collected on 2,442 children 1-11 years of age living in five socioeconomically matched pairs of open-cast and control communities in northern England. The data collection periods were 6 weeks each during 1996-1997 and the 52-week periods preceding these weeks. Consultations were categorized as respiratory, skin and eye conditions (possibly exacerbated by particulate matter), or other conditions. Over the 6-week periods, children in 4/5 pairs of open-cast and control communities had similar consultation rates for all conditions combined [2.7 vs. 2.4 per person-year; odds ratio (OR) = 1.1; 95% confidence interval (CI), 0.96-1.3). Consultations were higher in the open-cast communities for respiratory, skin, and eye conditions (2.1 vs. 1.5 per person-year; OR = 1.4; 95% CI, 1.2-1.7), and respiratory conditions alone (1.5 vs. 1.1 per person-year; OR = 1.5; 95% CI, 1.2-1.8). However, increases in consultation rates in open-cast communities were generally not seen over the portions of the 52-week periods when the open-cast sites were either active or inactive.
Methoxyflurane toxicity
Authors: E. J. Goldman
Journal: JAMA (1970)

<h3>To the Editor.—</h3> In addition to "Toxicity Following Methoxyflurane Anesthesia" (<b>214</b>:86, 1970), several articles in the past months noted renal failure following methoxyflurane anesthesia.<sup>1,2</sup>All suffer from a common information gap. The anesthetic administration and management is dismissed in a few words eg, "under methoxyflurane anesthesia..." "The surgery lasted six hours, and there was no hypoxia or hypotension." While it is reassuring to note the absence of hypoxia and hypotension, your anesthesiologist reader wishes to know a great deal more. What per cent of anesthetic was administered? Was it in a closed system, or a semiclosed system, or nonrebreathing? Was nitrous oxide used as well and in what concentration? What was the total flow of gas? Were muscle relaxants used or was the anesthetic pushed to deep levels to provide relaxation? How long was each setting used? The answers to these questions would allow us to guess at
Evaluation of a Recombinant Yeast Cell Estrogen Screening Assay
Authors: Nick G. Coldham, Mehul Dave, Susila Sivapathasundaram, Donald P. McDonnell, Caroline Connor, Maurice J. Sauer
Journal: Environmental Health Perspectives (1997)

A wide range of chemicals with diverse structures derived from plant and environmental origins are reported to have hormonal activity. The potential for appreciable exposure of humans to such substances prompts the need to develop sensitive screening methods to quantitate and evaluate the risk to the public. Yeast cells transformed with plasmids encoding the human estrogen receptor and an estrogen responsive promoter linked to a reporter gene were evaluated for screening compounds for estrogenic activity. Relative sensitivity to estrogens was evaluated by reference to 17 beta-estradiol (E2) calibration curves derived using the recombinant yeast cells, MCF-7 human breast cancer cells, and a prepubertal mouse uterotrophic bioassay. The recombinant yeast cell bioassay (RCBA) was approximately two and five orders of magnitude more sensitive to E2 than MCF-7 cells and the uterotrophic assay, respectively. The estrogenic potency of 53 chemicals, including steroid hormones, synthetic estrogens, environmental pollutants, and phytoestrogens, was measured using the RCBA. Potency values produced with the RCBA relative to E2 (100) included estrone (9.6), diethylstilbestrol (74.3), tamoxifen (0.0047), alpha-zearalanol (1.3), equol (0.085), 4-nonylphenol (0.005), and butylbenzyl phathalate (0.0004), which were similar to literature values but generally higher than those produced by the uterotrophic assay. Exquisite sensitivity, absence of test compound biotransformation, ease of use, and the possibility of measuring antiestrogenic activity are important attributes that argue for the suitability of the RCBA in screening for potential xenoestrogens to evaluate risk to humans, wildlife, and the environment.
Control groups
Authors: P. Sedgwick
Journal: BMJ (2010)

Researchers undertook a randomised controlled trial to assess the effect of zinc supplementation on the severity and duration of diarrhoea caused by cholera in children.1 Children were recruited if they had watery diarrhoea and dark field examination of stool was positive for Vibrio cholera (confirmed by stool culture). Children were randomly allocated to zinc supplementation or placebo. Zinc supplementation was found to reduce the duration and severity of diarrhoea in children with cholera. Which of the following statements, if any, are true?
Abstract 1874: A ZEB1-regulated EMT transcriptional program is associated with early nodal metastasis and improved survival for stage N2/N3 breast cancer patients
Authors: C James Block, Guojun Wu
Journal: Cancer Research (2019)

Abstract The epithelial-to-mesenchymal transition (EMT) is a transcriptionally-mediated process by which epithelial cells cease expression of cell-cell junction proteins, lose polarity, and begin expressing mesenchymal cytoskeletal and extracellular matrix components. While EMT is critical for normal development and wound healing, this process has been experimentally shown to be pathologically activated in cancer cells, leading to enhanced migratory and invasive capabilities, increased chemoresistance, and distant metastasis in mouse models. Consequently, EMT has been hypothesized to be a driving factor in metastatic progression and tumor recurrence in multiple cancer types, including breast cancer. EMT can be driven by several transcription factors (EMT-TFs) which are independently capable of inducing EMT and can regulate each other. Our group set out to identify EMT-TFs which were commonly activated across EMT models. By performing integrative analysis of multiple datasets, we determined that the EMT-TF ZEB1 demonstrates the most reproducible and consistent association with EMT in experimental models, breast cancer cell lines and in breast cancer patients. We then identified a high-confidence set of genes commonly upregulated in EMT and regulated by ZEB1. We observed that this ZEB1-associated transcriptional program is highly enriched for genes overexpressed in patients with early-stage node metastases compared to patients without lymph node involvement. Paradoxically, we observe that ZEB1 and ZEB1 associated genes exhibit higher expression in adjacent normal tissue samples than in primary tumor samples. Additionally, we discovered a reproducible association between ZEB1 and ZEB1-program gene expression and significantly improved recurrence-free and overall survival for breast cancer patients with distant lymph node involvement. This association was unique to ZEB1, as other EMT-TFs did not predict survival in these patients. In conclusion, our data demonstrate that the ZEB1-driven EMT program may contribute to early nodal metastasis, but that sustained ZEB1 expression may ultimately suppress cancer progression and improve survival. These findings may help clarify the specific contributions of different EMT-TFs to breast cancer progression. Citation Format: C James Block, Guojun Wu. A ZEB1-regulated EMT transcriptional program is associated with early nodal metastasis and improved survival for stage N2/N3 breast cancer patients [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1874.
Gut
Authors: Tamar Rubin
Journal: Annals of Internal Medicine (2014)

Ad Libitum4 March 2014GutTamar Rubin, MDTamar Rubin, MDFrom Edmonton, Alberta, Canada.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M13-1404 Audio Reading - “Gut” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Gut," by T. Rubin. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail This is more of a visceral thing, nothing you can weighagainst a strong argument.I'm moved by the beatof little wings, the twisting of locks.How does a squirm devour me?I carry a dead weight in one heartand a lead pipe in the other, grounding mein the draft of logic.Too many times I'e bit a dangling trope.Baited by a squeeze, I'e run with yardsand yards of gut.But almost nothing comes of nothing.I gather up stray feathers. The worm is gone.A tropeis better than nothing. I'e settled for a senseof gravity, a jackknife flash of weightiness.Tamar ... Author, Article, and Disclosure InformationAffiliations: From Edmonton, Alberta, Canada.Current Author Address: Tamar Rubin, MD; e-mail, [email protected]ca. PreviousarticleNextarticle Advertisement Audio Reading - “Gut” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Gut," by T. Rubin. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 4 March 2014Volume 160, Issue 5Page: 310KeywordsHeart ePublished: 4 March 2014 Issue Published: 4 March 2014 Copyright & PermissionsCopyright © 2014 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Physicians Study Medical Writing at Workshop
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Incorrect Author Affiliation
Authors: Bradley Turnwald, Danielle Boles, Alia Crum
Journal: JAMA Internal Medicine (2017)

Justin Grischkan, BA; Benjamin P. George, MD, MPH; Krisda Chaiyachati, MD, MPH; Ari B. Friedman, MD, PhD; E. Ray Dorsey, MD, MBA; David A. Asch, MD
A Supravital Cytodiagnostic Stain For Urinary Sediments
Authors: Richard Sternheimer
Journal: JAMA (1975)

<h3>To the Editor.—</h3> <i>Time</i>magazine's report (April 28,1975, p 78) of my paper (231:826, 1975) contained inaccuracies that confused those reading both publications. Three points must be made to set the record straight: (1) The stain was devised as an overall stain for urinary sediments. (2) Our experience with malignant neoplasia was incidental and so far has been limited to 12 cases. (3) The results of such diagnosis of cancer, by evaluating nuclear abnormalities, need verification on a large scale.
THE INDEX.
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Manual of Psychiatry.
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PURULENT OPHTHALMIA.
Authors: DUDLEY S. REYNOLDS
Journal: JAMA (1896)

Purulent conjunctivitis should have a degree of significance to the physician according to the character of the infection and the age of the patient. While there are many varying degrees of intensity, for clinical purposes, it is best to recognize but two causes; the gonorrheal and the endemic. The gonorrheal is most malignant and intractable; it seldom occurs in both eyes simultaneously. It is most common in adults, and is the result of contagion. The endemic is equally contagious and differs in its clinical features from the gonorrheal type in degree of severity and extent of invasion. In gonorrheal inflammation, the cocci not only attack the mucous corpuscles and surface epithelium, but penetrate quickly into the mucous follicles, which become greatly distended, causing such interruption in the circulation of the blood in the capillary coils surrounding the follicles that great edema is quickly set up, producing a degree of swelling
CONDITION OF THE BLOOD IN GASTRIC AFFECTIONS.
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Editorial board, Contents, Forthcoming articles
Authors: Kathryn Jeffery, Neil Burgess, Valerie Stone, Philip Gerrans, Gergely Csibra, Victoria Southgate, Ron Chrisley, Michael Dawson, Michael Kalish, Charles Barousse, Victor Johnston, Kalanit Grill-Spector, Richard Henson, Alex Martin, Annett Schirmer, Sonja Kotz, Christopher Hsee, Reid Hastie, John Serences, Steven Yantis Trendsin, Julian Ogilvie, Katie Forsythe, Manager Moulton
Journal: Trends in Cognitive Sciences (2006)