tbuckley/cabot-search huggingface dataset:
Course of acquired aplastic anemia in children treated with supportive care
Authors: R. M. Heyn
Journal: JAMA (1969)

Of 33 children with acquired aplastic anemia, 15 have recovered and two still require transfusions. Sixteen (48.4%) have died. All of these children received supportive care but no androgenic treatment. Although the initial picture in the bone marrow can be correlated with death or survival, no present parameters of measurement indicate how long recovery will take. The course of the disease to recovery is a widely variable one but is similar to that reported by others in patients who receive androgenic therapy. Further experience with the natural course of the disease seems warranted.
Low Back Pain
Authors: Paramvir Sidhu, Mandeep Brar
Journal: Annals of Internal Medicine (2014)

Letters18 November 2014Low Back PainParamvir Sidhu, MD and Mandeep Brar, MDParamvir Sidhu, MDFrom Franciscan Medical Group, Tacoma Washington.Search for more papers by this author and Mandeep Brar, MDFrom Franciscan Medical Group, Tacoma Washington.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L14-5024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Chou's In the Clinic issue (1) made some excellent points about management of back pain. However, we believe that it did not sufficiently stress the need for differentiating inflammatory from mechanical back pain and contained some inaccuracies about the prevalence of ankylosing spondylitis in patients with back pain in general and inflammatory back pain in particular.Most studies have shown that the prevalence of axial spondyloarthritis (including ankylosing spondylitis) in patients with chronic back pain is approximately 5% rather than the lower prevalence that this issue suggests. Chou states that the positive predictive value of inflammatory back ...References1. Chou R. In the clinic. Low back pain. Ann Intern Med. 2014;160:ITC6-1. [PMID: 25009837] LinkGoogle Scholar2. Rudwaleit M, Metter A, Listing J, Sieper J, Braun J. Inflammatory back pain in ankylosing spondylitis: a reassessment of the clinical history for application as classification and diagnostic criteria. Arthritis Rheum. 2006;54:569-78. [PMID: 16447233] CrossrefMedlineGoogle Scholar3. Hermann J, Giessauf H, Schaffler G, Ofner P, Graninger W. Early spondyloarthritis: usefulness of clinical screening. Rheumatology (Oxford). 2009;48:812-6. [PMID: 19447774] doi:10.1093/rheumatology/kep119 CrossrefMedlineGoogle Scholar4. Weisman MH, Chen L, Clegg DO, Davis JC, Dubois RW, Prete PE, et al. Development and validation of a case ascertainment tool for ankylosing spondylitis. Arthritis Care Res (Hoboken). 2010;62:19-27. [PMID: 20191487] doi:10.1002/acr.20009 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Paramvir Sidhu, MD; Mandeep Brar, MDAffiliations: From Franciscan Medical Group, Tacoma Washington.Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L14-0378. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoLow Back Pain Roger Chou Metrics 18 November 2014Volume 161, Issue 10Page: 761-762KeywordsAlgorithmsAnkylosing spondylitisConflicts of interestDisclosureInflammatory bowel diseaseLower back painMedical risk factorsPositive predictive valuePsoriasisUveitis ePublished: 18 November 2014 Issue Published: 18 November 2014 Copyright & PermissionsCopyright © 2014 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Cardiac Exercise Program
Journal: JAMA (1979)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Patterns of hepatitis C prevalence and seroconversion in hemodialysis units from three continents: The DOPPS
Authors: Rachel B. Fissell, Jennifer L. Bragg-Gresham, John D. Woods, Michel Jadoul, Brenda Gillespie, Sara A. Hedderwick, Hugh C. Rayner, Roger N. Greenwood, Takashi Akiba, Eric W. Young
Journal: Kidney International (2004)
Adverse events following pertussis and rubella vaccines. Summary of a report of the Institute of Medicine
Authors: C. P. Howson
Journal: JAMA (1992)

In August 1991, the Institute of Medicine released a report entitled<i>Adverse Effects of Pertussis and Rubella Vaccines</i>, which examined 18 adverse events in relation to diphtheria-tetanus-pertussis (DTP) vaccine and four adverse events in relation to the currently used rubella vaccine strain, RA 27/3. The committee spent 20 months reviewing a wide range of information sources, including case series and individual case reports, both published and unpublished, epidemiologic studies, studies in animals, and other laboratory studies. The committee found that the evidence indicates a causal relation between DTP vaccine and anaphylaxis and between the pertussis component of DTP vaccine and extended periods of inconsolable crying or screaming. The committee also reported that the evidence indicates a causal relation between the rubella vaccine and acute arthritis in adult women. The committee found the available evidence weaker but still consistent with a causal relation between DTP vaccine and two conditions—acute encephalopathy and hypotonic, hyporesponsive episodes—and between rubella vaccine and chronic arthritis in adult women. Estimated incidence rates of these adverse events following vaccination are provided, where possible. The committee found that the evidence does not indicate a causal relation between the DTP vaccine and infantile spasms, hypsarrhythmia, Reye's syndrome, and sudden infant death syndrome. The committee found insufficient evidence to indicate either the presence or absence of a causal relation between DTP vaccine and chronic neurologic damage, aseptic meningitis, erythema multiforme or other rash, Guillain-Barré syndrome, hemolytic anemia, juvenile diabetes, learning disabilities and attention-deficit disorder, peripheral mononeuropathy, or thrombocytopenia, and between rubella vaccine and radiculoneuritis and other neuropathies or thrombocytopenic purpura. The committee's evaluative methods are briefly described and a summary of research needs is provided. (<i>JAMA</i>. 1992;267:392-396)
Residential Water Source and the Risk of Childhood Brain Tumors
Authors: Beth A. Mueller, Katherine Newton, Elizabeth A. Holly, Susan Preston-Martin
Journal: Environmental Health Perspectives (2001)

Gestation may represent a window of susceptibility to transplacental effects of environmental exposures, including chemicals in water. The N-nitroso compounds (NNC), a class of chemicals with demonstrated neurocarcinogenic potential, include substances detected in drinking water. We used data from a study of possible risk factors for childhood brain tumors (CBT) to investigate the association of source of residential drinking water during pregnancy and CBT occurrence among offspring. In addition, dipstick measurements were made of nitrates and nitrites in tap water for the subset of women living in the same home they had lived in during their pregnancies. Population-based CBT cases (n = 540) and controls (n = 801) were identified in three regions including Los Angeles County, and the San Francisco Bay Area of California, and the Seattle-Puget Sound area of western Washington state. Overall, we observed no increased risk of CBT in offspring associated with wells as the source of residential water. However, an increased risk of CBT [odds ratio (OR) = 2.6; 95% confidence interval (CI), = 1.3-5.2] was observed in western Washington among offspring of women who relied exclusively on well water, and a decreased risk of CBT (OR = 0.2; 95% CI, 0.1-0.8) was observed in Los Angeles County. Among the small subset of subjects for whom dipstick measurements of tap water were available, the risk of CBT associated with the presence of either measurable nitrite and/or nitrate was 1.1 (95% CI, 0.7-2.0). Given the crude measurement method employed and because measurements often were obtained years after these pregnancies occurred, the relevance of the dipstick findings is unclear. The lack of consistency in our findings related to residential water source does not support the hypothesis of increased risk related to consumption of well water; however, regional differences in well water content may exist, and the increased risk observed in western Washington deserves further evaluation.
Molecular and Functional Analysis of Stem Cell Compartment of Chronic Myelogenous Leukemia Reveals the Presence of a CD34− cell Population with Intrinsic Resistance to IMATINIB Treatment
Authors: Valentina Salvestrini, Rossella Manfredini, Miriam Fogli, Elisa Bianchi, Simona Salati, Marilina Amabile, Francesco Bertolini, Agostino Tafuri, Roberta Zini, Nicoletta Testoni, Cristina Rabascio, Lara Rossi, Giovanni Martinelli, Michele Baccarani, Sergio Ferrari, Roberto M Lemoli
Journal: Blood (2008)
From the Centers for Disease Control. Preventing electrocutions during work with scaffolds near overhead power lines
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 1104: Targeting the stress response kinase GCN2 to restore immunity in the tumor microenvironment
Authors: Buvana Ravishankar, Lavanya Adusumilli, Deepa Pookot Pookot, Emily Huang, Raashi Sreenivasan, Lisa Marshall, Deepika Kaveri, Oezcan Talay, Silpa Suthram, Svetlana Miakicheva, Abood Okal, Mikhail Zibinsky, Jeffrey Jackson, Grant Shibuya, Paul Leger, Parcharee Tivitmahaisoon, Scott Jacobson, Steve Wong, Angela Wadsworth, Jerick Sanchez, Martin Brovarney, David Chian, Sachie Marubayashi, Aparna Jorapur, Delia Bradford, Christophe Colas, Gene Cutler, Jacob Schwartz, David Wustrow, Paul Kassner, Dirk Brockstedt
Journal: Cancer Research (2019)

Abstract The tumor microenvironment (TME) is characterized by deficiencies in oxygen and key nutrients, such as glucose and amino acids, resulting in an overall immune-suppressive environment. Key suppressive cell types in the TME include tumor, stromal and myeloid-derived suppressor cells (MDSC) which create a nutrient-poor environment that supports tumor growth and limits immune surveillance. General control nonderepressible 2 (GCN2), a stress response kinase, plays a key role in sensing and modulating the cellular response to amino acid deprivation. GCN2 activation in T cells triggers the integrated stress response pathway and promotes T cell anergy and apoptosis. We have developed small molecule GCN2 inhibitors (GCN2i) that are highly potent and selective in vitro. Culturing primary mouse or human immune cells under low nutrient conditions activates the GCN2 pathway limiting T cell proliferation and function. Treatment of these nutrient-deprived T cells with GCN2i resulted in rescue of CD8+ T cell proliferation and effector functions. In addition, GCN2 inhibition in MDSC alone fully reversed CD33+MDSC-induced T cell suppression and effector functions. Our GCN2 inhibitors are orally bioavailable with drug like in vivo ADME properties. Our GCN2i is currently being evaluated in vivo, in murine syngeneic tumor models. Our results demonstrate that inhibition of GCN2 is an attractive approach for relieving T cell suppression and promoting effector function, demonstrating GCN2 as a promising therapeutic target for the treatment of cancer. Note: This abstract was not presented at the meeting. Citation Format: Buvana Ravishankar, Lavanya Adusumilli, Deepa Pookot Pookot, Emily Huang, Raashi Sreenivasan, Lisa Marshall, Deepika Kaveri, Oezcan Talay, Silpa Suthram, Svetlana Miakicheva, Abood Okal, Mikhail Zibinsky, Jeffrey Jackson, Grant Shibuya, Paul Leger, Parcharee Tivitmahaisoon, Scott Jacobson, Steve Wong, Angela Wadsworth, Jerick Sanchez, Martin Brovarney, David Chian, Sachie Marubayashi, Aparna Jorapur, Delia Bradford, Christophe Colas, Gene Cutler, Jacob Schwartz, David Wustrow, Paul Kassner, Dirk Brockstedt. Targeting the stress response kinase GCN2 to restore immunity in the tumor microenvironment [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1104.
The hospital bill that Medicare won't pay
Authors: D. J. Dalessio
Journal: JAMA (1975)

FOR SOME time now, the intermediaries who administer Medicare have been sending notices to patients for whom payment for hospital services has been denied. It is their practice to send a mimeographed letter, unmodified and impersonal, no matter what the reason for the denial. An excerpt from that letter follows: Medicare will cover inpatient hospital services when the patient requires treatment or necessary diagnostic studies and these services can be furnished appropriately only while in the hospital. Since the services you received do not meet this requirement, no hospital insurance benefits can be paid for your stay. A determination has been made that you had no knowledge nor any way of knowing that the services you received during this stay were not medically necessary. However, the records show that this hospital knew or should have known that such a service would be considered non-covered. It has therefore been determined that
The iTind temporarily implanted nitinol device for the treatment of lower urinary tract symptoms secondary to benign prostatic hyperplasia: A multicenter, randomized, controlled trial
Authors: B. Chughtai, D. Elterman, N. Shore, M. Gittleman, J. Motola, S. Pike, C. Hermann, W. Terens, A. Kohan, R. Gonzalez, A. Katz, J. Schiff, E. Goldfischer, I. Grunberger, L.M. Tu, M. Alshak, J. Kaminetsky
Journal: European Urology (2021)
A Perspective on the Potential Development of Environmentally Acceptable Light-Duty Diesel Vehicles
Authors: Robert Hammerle, Dennis Schuetzle, Willi Adams
Journal: Environmental Health Perspectives (1994)

Between 1979 and 1985, an international technical focus was placed upon potential human health effects associated with exposure to diesel emissions.A substantial data base was developed on the composition of diesel emissions; the fate of these emissions in the atmosphere; and the effects of whole particles and their chemical constituents on microorganisms, cells, and animals.Since that time, a number of significant develop- ments have been made in diesel engine technology that require a new look at the future acceptability of introducing significant numbers of light-duty diesel automobiles into the European and American markets.Significant engineering improvements have been made in engine design, catalysts, and traps.As a result, particle emissions and particle associated organic emissions have been reduced by about 10 and 30 times, respectively, dur- ing the past 10 years.Research studies to help assess the environmental acceptability of these fuel-efficient engines include the development of an emissions data base for current and advanced diesel engines, the effect of diesel emissions on urban ozone formation and atmospheric particle con- centrations, the effect of fuel composition, e.g., lower sulfur and additives on emissions, animal inhalation toxicology studies, and fundamental mole-
Abstracts
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Graft vs. host disease after liver transplantation in humans: A report of four cases
Authors: J Roberts
Journal: Hepatology (1991)

Four cases of patients in whom graft vs. host disease developed after liver transplantation are described. The clinical course of each patient was similar with fever, pancytopenia, diarrhea and a skin rash developing 1 or 2 mo after liver transplantation. The clinical diagnosis was made from skin or colon biopsy specimens. Liver dysfunction did not occur in the patients at the time of diagnosis. Extrahepatic donor DNA was identified in the three patients it was tested for. Three patients died from the complications of the disease primarily related to sepsis. The other patient recovered from the graft vs. host disease but died from lymphoproliferative disease. (HEPATOLOGY 1991;14:274–281.)
Doubling of Dosage of Penicillin In Treating Gonorrhea Recommended
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diuretic Therapy
Authors: D. Craig Brater
Journal: New England Journal of Medicine (1998)

Diuretic drugs are widely used for the treatment of patients with edema. Among these drugs, loop diuretics such as furosemide are perhaps the most frequently prescribed, and their clinical pharmacology is better understood than is that of other diuretics. This review will therefore focus on this class of diuretics, but others will be discussed as well.Clinical Pharmacology of DiureticsPharmacokineticsThe pharmacologic characteristics of all loop diuretics are similar. Therefore, a lack of response to adequate doses of one loop diuretic militates against the administration of another loop diuretic; instead, combinations of diuretics with different mechanisms of action should . . .
Should Nephrectomy Be Performed on Infants with Enlarged Hematuric Kidneys?
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal