tbuckley/cabot-search huggingface dataset:
Abstract 2112: Structural characterization of transmembrane protein TMEM205
Authors: Xiaoyun Bai, Di Xia
Journal: Cancer Research (2019)

Abstract Cisplatin resistance is notorious in leading to therapeutic failure of many solid malignancies. Various resistance mechanisms have been proposed while many more are being added, based on the growing number of resistance-inducing genes identified. TMEM205 is an integral membrane protein with unknown function, but its intracellular level was found markedly elevated in cisplatin resistance cells, the mechanism of which is unknown. Here for the first time we characterized the molecular mechanism of TMEM205-mediated cisplatin resistance through structural and functional studies of TMEM205. The crystal structure of the full-length TMEM205 was obtained at 2.5 Å resolution and shows a 4-helix bundle with a highly hydrophilic tunnel. Strong anomalous signals were observed indicating platinum binding sites. Our structural and functional study of TMEM205 provides novel insight into the complexity of cisplatin resistance. Citation Format: Xiaoyun Bai, Di Xia. Structural characterization of transmembrane protein TMEM205 [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2112.
The follow-up and lifestyle (FUCSAM project). Oncology Network of Piemonte and Valle d'Aosta (ROPVdA): update 2016.
Authors: F. Sarli, L. Giordano, F. Gallo, I. Romaniello, F. Pietribiasi, D. Solerio, M.G. Pacquola, F. Castiglione, P. Bellingeri, N. De Piccoli, A. Fedi, S. Gattino, C. Finocchiaro, M.P. Mano, C. Monagheddu, M. Ceccarelli, G. Ciccone, C. Senore, M. Mistrangelo, O. Bertetto
Journal: Annals of Oncology (2016)
Hepatitis B virus nucleic acids associated with human peripheral blood mononuclear cells do not originate from replicating virus
Authors: J KOCK
Journal: Hepatology (1996)

There have been numerous reports suggesting that human peripheral blood mononuclear cells (PBMCs) can be productively infected with human hepatitis B virus (HBV). We therefore examined whether the PBMCs can be used to establish an in vitro infection system for HBV. Freshly purified PBMCs were incubated with HBV with or without mitogen stimulation. Successful infection was tested using a newly developed PCR method that can differentiate between the relaxed circular (RC) DNA of the virus inoculum and the covalently closed circular (CCC) DNA which is formed only after successful virus entry. This method enables virus uptake to be proven even if the infection is abortive because there is no gene expression because of the lack of liver specific gene expression factors. All attempts to detect CCC DNA after incubation of PBMCs with HBV failed. On the contrary, CCC DNA could easily be detected in infected liver or after in vitro infection of primary human hepatocytes. Because this result appeared to be contradictory to the published data, we analyzed PMBCs isolated from infected patients. We could confirm that HBV DNA and RNA are associated with these cells. However, even after restimulation with mitogens, we could only detect RC DNA. Moreover, we could also demonstrate that viral RNA is present in free virus. Apparently, a certain amount of defective particles do not reverse transcribe the packaged pregenomic RNA. In summary we found no evidence that PMBCs can be infected with HBV and conclude that all previous observations can be explained by adsorbed virus. (Hepatology 1996 Mar;23(3):405-13)
National Eye Institute Issues Clinical Alert About CMV Retinitis in AIDS
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pediatric ibuprofen and leukopenia
Authors: S. M. Lesko
Journal: JAMA (1996)

<h3>To the Editor.</h3> —I thoroughly enjoyed your description of<i>World Series</i>by Arnold Friedman<sup>1</sup>on the cover of<i>JAMA</i>. I also wish to make you aware of a compositional error in the piece. All professional baseball parks should have home plate in the southwest corner of the playing field (this is the reason left-handed pitchers are called "southpaws" since their throwing arm is always on the south side of the mound), according to the official baseball rulebook (oral communication, Bill Valentine, General Manager, Arkansas Travellers, March 13, 1996). The error is in the direction of the shadows, which would indicate a sun position low in the southeast—as it would be at 7 or 8 o'clock in the morning. This lighting discrepancy does nothing to detract from the atmosphere the piece creates or the enjoyable (and not overblown) critique. I suspect other baseball fans will have notified you of the
MEDICAL-PHARMACEUTICAL CONFERENCE
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BOOK REVIEWS
Authors: D. T. CARR
Journal: JNCI Journal of the National Cancer Institute (1992)

BOOK REVIEWS Get access Atlas of Lung Cancer and Other Chest Tumors Margaret Turner-Warwick , Margaret E. Hodson , Bryan Corrin , Ian H. Kerr , eds. London : Gower Med. Publ. , 1991 . 112 pp., illus. $65 DAVID T. CARR DAVID T. CARR Section of Head, Neck and Thoracic, Medical Oncology, University of Texas M. D. Anderson, Cancer Center, 1515 Holcombe BlvdHouston, TX 77030 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 84, Issue 8, 15 April 1992, Page 641, https://doi.org/10.1093/jnci/84.8.641 Published: 15 April 1992
Minimal brain dysfunction. Management of family distress
Authors: I. N. Berlin
Journal: JAMA (1974)

The diagnosis and adequate treatment of minimal brain dysfunction (MBD) requires very early identification of neurophysiologic and behavioral disturbances. Comprehensive care of this disorder requires early involvement of parents in understanding the diagnosis and its implications and in learning about infant management. We must understand that whether stimulant medication works or not, the very early socialization patterns which govern reactions to discipline, learning, and interpersonal relations, once acquired, are difficult to change and affect the child's entire life. The physician's old aphorism, "Don't worry, the child will grow out of it," is very harmful when applied to the MBD child. Mothers need help with management of their infants. Sharing the problems such an infant brings to the family is most effective in an organized program. The physician must help parents with the frequent feelings of blame, and must serve as a model of how the child's problems can be openly and honestly discussed with him. Comprehensive care makes it possible for parents and child to share their problems with others when they are under stress. (<i>JAMA</i>229:1454-1456, 1974)
Abstract 1147: A phage display identified peptide selectively binds to kidney injury molecule-1(KIM-1) and detects KIM-1-overexpressing tumors <i>in vivo</i>
Authors: Jae-Won Yoon, Soo-woong Lee, Md. Enamul Haque, Rang- Woon Park, Moon-Chang Baek, Dong-Kyu Kim, Sang Kyoon Kim, Byungheon Lee
Journal: Cancer Research (2019)

Abstract Kidney injury molecule-1 (KIM-1), also known as hepatitis A virus cellular receptor-1 and T cell Ig mucin-1, is a transmembrane protein, which is not overexpressed in normal kidneys, but is significantly upregulated in damaged kidney tubular epithelial cells in toxic and ischemic acute kidney injury. Of interest, KIM-1 is overexpressed in most cases of renal cell carcinoma (RCC) and in other types of tumors including ovarian clear cell carcinoma and lung cancer. The extracellular domain of KIM-1 can be identified in the urine of patients with RCC and can thus be used as a biomarker for the detection of RCC. This study was carried out to identify a peptide that selectively binds to KIM-1 by screening a phage-displayed peptide library and to use the peptide for the detection of KIM-1-overexpressing tumors in vivo. Biopanning of a phage-displayed peptide library was performed on KIM-1-coated plates. Compared to other phage clones selected after biopanning, a phage clone displaying the CNWMINKEC peptide showed higher binding affinity to KIM-1 as examined by fluorometry and KIM-1-overexpressing 769-P renal tumor cells 1 as examined by ELISA. The CNWMINKEC peptide and a NeutrAvidin/biotin-CNWMINKEC multimer selectively bound to KIM-1 over albumin as examined by fluorometry and to KIM-1-overexpressing 769-P cells and A549 lung tumor cells compared to KIM-1-low expressing HEK293 normal cells when examined by flow cytometry. Co-localization and competition assays using an anti-KIM-1 antibody demonstrated that the binding of the CNWMINKEC peptide to 769-P cells was specifically mediated by KIM-1. Whole-body fluorescence imaging demonstrated selective homing of the CNWMINKEC peptide to KIM-1-overexpressing A498 renal tumor compared to KIM-1-low expressing HepG2 liver tumor in mice. The CNWMINKEC peptide was not cytotoxic to cells and was stable for up to 24 h in the presence of serum. These results suggest that the CNWMINKEC peptide is a promising probe for in vivo imaging and detection of KIM-1-overexpressing tumors. Keywords In vivo imaging, kidney injury molecule-1, peptide, phage display, renal cell carcinoma Note: This abstract was not presented at the meeting. Citation Format: Jae-Won Yoon, Soo-woong Lee, Md. Enamul Haque, Rang- Woon Park, Moon-Chang Baek, Dong-Kyu Kim, Sang Kyoon Kim, Byungheon Lee. A phage display identified peptide selectively binds to kidney injury molecule-1(KIM-1) and detects KIM-1-overexpressing tumors in vivo [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1147.
In this issue
Authors: Peter Kirkpatrick Senior, Alexandra Flemming, Charlotte Harrison, Sarah Crunkhorn Associate, Megan Cully Assistant, Katie Kingwell, Mariam Faruqi, Susanne Harris, Catriona Rodwell Editorial Assistants, Emily Finn, Rebecca Cromie, Judith Shadwell, Simon Fenwick, Patrick Morgan, Vicky Summersby, Natalie Smith
Journal: Nature Reviews Drug Discovery (2014)
Translational research
Authors: M E J Lean, J I Mann, J A Hoek, R M Elliot, G Schofield
Journal: BMJ (2008)

<h3>Abstract</h3> Vocal learning in songbirds is mediated by a highly localized system of interconnected forebrain regions, including recurrent loops that traverse the cortex, basal ganglia, and thalamus. This brain-behavior system provides a powerful model for elucidating mechanisms of vocal learning, with implications for learning speech in human infants, as well as for advancing our understanding of skill learning in general. A long history of experiments in this area has tested neural responses to playback of different song stimuli in anesthetized birds at different stages of vocal development. These studies have demonstrated selectivity for different song types that provide neural signatures of learning. In contrast to the ease of obtaining responses to song playback in anesthetized birds, song-evoked responses in awake birds are greatly reduced or absent, indicating that behavioral state is an important determinant of neural responsivity. Song-evoked responses can be elicited during sleep as well as anesthesia, and the selectivity of responses to song playback in adult birds is highly similar between anesthetized and sleeping states, encouraging the idea that anesthesia and sleep are similar. In contrast to that idea, we report evidence that cortical responses to song playback in juvenile zebra finches (<i>Taeniopygia guttata</i>) differ greatly between sleep and urethane anesthesia. This finding indicates that behavioral states differ in sleep versus anesthesia and raises questions about relationships between developmental changes in sleep activity, selectivity for different song types, and the neural substrate for vocal learning.
INTERNATIONAL SANITATION.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
LAW &amp; MEDICINE
Authors: Angela Roddey Holder
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TYPHOID FEVER IN THE DISTRICT OF COLUMBIA.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Book Review Principles and Practice of Obstetrics . By Joseph B. DeLee, A.M., M.D., Professor of Obstetrics, Northwestern University Medical School. Fifth Edition, Thoroughly Revised. Large octavo of 1140 pages, with 1128 illustrations, 201 in colors. Philadelphia and London: W. B. Saunders Company, 1928. Cloth $12.00 net.
Journal: New England Journal of Medicine (1930)
PULMONARY CIRCULATION
Authors: R. J. S. McDowall
Journal: BMJ (1921)

CLAYDEN V. WVOOD-HILL.SIR,-Ille facts of tlle case of Clayden v. NVood-Hill, recently decided at the Suffolk Assizes, a report of which iappeared in your issue of November 26th, when a verdict of £750 damages was given against a medical man for alleged negliaence in the treatmnent of a fractured femur, should be studied by all medical practitioners.The plaintiff was thrown out of a trap and sustained a fracture of the upper third of the riglht femuur.Two days later slhe was mioved to the Beccles Cottage Hospital, in Suffolli, whero Dr. Wood-Hill of Beceles attended her.The fraaguents united, and in eight weeks she returned home to H-ertfordshire, with strict instructions from Dr. \Wood-Hill tllat no weight was to be borne by the limb without tlle permission of her fam-ily doctor.A week later, when standiDng in her room at home, she felt tlle limib give way and she fell on to a sofa.Abundant evidence was produced at the trial that as regards splinting, extension, and position of the limb, the fracture wyas treated in accordance with modern methods wlhile the plaintiff was an inmate of the Beccles Cottage Hospital.Tlle verdict of tlle jury largely turned on the question as to whether, at the second accident nine weeks after the first, a giving -way of the previously united fragments took place.Bv very adroitly drawing from one item in tlle znedical evidence bearing on this question an inference wlhicl, from a mneclical point of view, was entirely unjusti- fiable, counsel for the plaintiff in(luced the jury to brina in a verdict for the plainltiff witlh damages as stated.Mlaily of tllose wlho watched the case tlhrouglhout its course are convinced that a grave miscarriage of justice lhas taken place, and for this reason a fund has been started to reimburse Dr. Wood-Hill in the very heavy expenses incurred by hlim, which, we are informed, will amount, with costs, to about £1,600.Naturally the question of appeal has been very carefully considered, anid Dr. Wood- Hill hias beeni advised against thlis course by botlh hiis counsel anld hlis solicitor.It is true that at the time of tlle trial Dr. Wood-Hill was not a memuber of one of tlle medical defence societies, but this, although slhowing a Jack of foresighit on his part, is no reason for refusinOg to lhelp
Relationship Between Antidepressants and Suicide Attempts: An Analysis of the Veterans Health Administration Data Sets
Authors: Robert Gibbons
Journal: American Journal of Psychiatry (2007)

Objective: In late 2006, a U.S. Food and Drug Administration advisory committee recommended that the 2004 black box warning regarding suicidality in pediatric patients receiving antidepressants be extended to include young adults. This study examined the relationship between antidepressant treatment and suicide attempts in adult patients in the Veterans Administration health care system. Method: The authors analyzed data on 226,866 veterans who received a diagnosis of depression in 2003 or 2004, had at least 6 months of follow-up, and had no history of depression from 2000 to 2002. Suicide attempt rates overall as well as before and after initiation of antidepressant therapy were compared for patients who received selective serotonin reuptake inhibitors (SSRIs), new-generation non-serotonergic-specific (non-SSRI) antidepressants (bupropion, mirtazapine, nefazodone, and venlafaxine), tricyclic antidepressants, or no antidepressant. Age group analyses were also performed. Results: Suicide attempt rates were lower among patients who were treated with antidepressants than among those who were not, with a statistically significant odds ratio for SSRIs and tricyclics. For SSRIs versus no antidepressant, this effect was significant in all adult age groups. Suicide attempt rates were also higher prior to treatment than after the start of treatment, with a significant relative risk for SSRIs and for non-SSRIs. For SSRIs, this effect was seen in all adult age groups and was significant in all but the 18–25 group. Conclusions: These findings suggest that SSRI treatment has a protective effect in all adult age groups. They do not support the hypothesis that SSRI treatment places patients at greater risk of suicide.
Filling defect in the urinary bladder
Authors: J. M. Korsower
Journal: JAMA (1975)

<h3>Common</h3> Blood clot Calculus Instrument (eg, Foley catheter) Neoplasm, intrinsic or invasive Polyp Prostatic enlargement Ureterocele, simple or ectopic <h3>Uncommon</h3> Endometriosis Foreign body Fungus ball (eg, monilia) Hematoma, intramural Hydatid cyst Infection, fistula, abscess (eg, from Crohn disease or diverticulitis) Postoperative Schistosomiasis hematobium (granuloma or polyp) <h3>Diagnosis</h3> Prostatic hypertrophy appearing as an intravesical mass. <h3>Comment</h3> An elderly man had a typical history of prostatism and bladder outlet obstruction. Rectal examination showed no abnormalities, but a large intramural mass was noted in the bladder neck on cystoscopy. The intravenous pyelogram shows a smooth, round filling defect within the bladder in an inferior midline location. It appeared to be in the lumen, but elevation of the distal ends of the ureters and trigone indicates an intramural or extrinsic lesion, since a purely intraluminal mass would not