tbuckley/cabot-search huggingface dataset:
University of Montreal.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Human prolactin.
Authors: E Daw
Journal: BMJ (1971)

Mr. A. R. Gurd (personal communication) has shown that the insertion of cemented or non-cemented prostheses, or Kuntchner nails, all produce similar and marked in- creases in the levels of fat in blood from the femoral vein.It is not surprising that fat is frequently found in the pulmonary vessels of these patients postoperatively.Not much significance can be attached to this finding unless it is combined with an assessment of cardiopulmonary function.Dr. Gresham and colleagues do not comment on fat in the systemic circulation of the patients who died following Thompson prostheses.Patients undergoing femoral head replace- ment with Thompson prostheses are generally old, with pre-existing cardiopul- monary disorders.They are subjected to a second severe episode of stress at operation within a variable interval of the original trauma.A higher mortality rate in these patients compared to those undergoing total hip replacement may be related to the un- satisfactory general condition of the former and to the fact that they are suffering a second episode of stress.-Weare, etc.,
Impact of critical care physician staffing on patients with septic shock in a university hospital medical intensive care unit
Authors: H. N. Reynolds
Journal: JAMA (1988)

To evaluate the effects of reorganizing physician resources in a medical intensive care unit (MICU), we studied the impact of these changes in patients with septic shock. Patients were compared during two consecutive 12-month periods: (1) an interval in which faculty without critical care medicine (CCM) training supervised the MICU (before CCM, n = 100) and (2) following staffing with physicians formally trained in CCM (after CCM, n = 112). Acute Physiology and Chronic Health Evaluation scores were utilized to compare severity of illness and were similar for each group (29 ±11 before CCM vs 28 ± 10 after CCM). However, mortality was significantly lower during the post-CCM interval (74% vs 57%, respectively). There was no significant difference in the frequency of use of mechanical ventilation (83% vs 87%), although pulmonary artery catheters (48% vs 64%) and arterial catheters (24% vs 73%) were employed more frequently after CCM. The number of subspecialty consultations and MICU and hospital length of stay were similar for both intervals. We conclude that the implementation of dedicated staffing by CCM physicians in a university hospital MICU was associated with a favorable impact on patients with septic shock. (<i>JAMA</i>1988;260:3446-3450)
Principles of Ambulatory Medicine
Authors: Harold Nachimson
Journal: JAMA (1987)

To revisit an old friend is always a delight and so it is with the second edition of this extensive, well-constructed text. I was privileged to review the initial edition and, indeed, encouraged further editions. The format remains unchanged, with the book directed toward general physicians who care for ambulatory adult patients. With this setting in mind, one should not expect to find extensive treatment of pediatrics, surgery, or obstetrics, except in their impact on outpatient encounters. I was particularly impressed with the "stand alone" quality of each area treated. Section 1, "Issues of General Concern on Ambulatory Care," should be read by everyone in medical practice. Issues such as the doctor-patient relationship, communication between doctor and patient, preventive medicine, and compliance are included. These are generic issues in medical practice, and the authors do justice to them. Unlike many existing medical texts, this book's sections are problem oriented rather
Autobiography of a Physiologist
Authors: A. G. M. Weddell
Journal: BMJ (1970)

perform the investigation and interpret -the films.It is an extremely thorough review condensed into a short readable book with many excellent illustrations.The most in- structive sections are those that deal with practical techniques-especially the methods of selective catheterization of the tribu- taries-and the pitfalls of interpretation.This book should be in the office of all vascular radiologists, and is worthy of study by both physicians and surgeons, who would quickly learn the great value of this simple but neglected and underrated method of clinical investigation.
Fat in the Stool of Persons Who Eat Olestra Potato Chips
Journal: Annals of Internal Medicine (2000)

Summaries for Patients15 February 2000Fat in the Stool of Persons Who Eat Olestra Potato ChipsSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-4-200002150-00031 SectionsAboutFull Text ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Olestra is a fat substitute that recently became available. It tastes like ordinary fats and is used to make some snack products, such as fat-free potato chips. The body does not absorb olestra and excretes it in stool. This means that people can eat food that contains this fat without absorbing any of the bad things (such as added calories and cholesterol) that come from eating food that contains fats that are absorbed. Abnormal amount of fat in the stool is known as steatorrhea. Steatorrhea occurs in diseases ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Positive Results on Tests for Steatorrhea in Persons Consuming Olestra Potato Chips.” It is in the 15 February 2000 issue of Annals of Internal Medicine (volume 132, pages 279-282). The authors are R. Balasekaran, J.L. Porter, C.A. Santa Ana, and J.S. Fordtran.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoPositive Results on Tests for Steatorrhea in Persons Consuming Olestra Potato Chips Ranga Balasekaran , Jack L. Porter , Carol A. Santa Ana , and John S. Fordtran Metrics 15 February 2000Volume 132, Issue 4Page: 279KeywordsCholesterolEatingFatsFoodNutrientsTaste ePublished: 15 August 2000 Issue Published: 15 February 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.Loading ...
Investments that Work for Physical Activity
Journal: British Journal of Sports Medicine (2012)

Physical inactivity is the fourth leading cause of deaths due to non-communicable disease (NCDs) worldwideheart disease, stroke, diabetes and cancers -and each year contributes to over three million preventable deaths. 1 Physical inactivity is related (directly and indirectly) to the other leading risk factors for NCDs such as high blood pressure, high cholesterol and high glucose levels; it underpins the recent striking increases in childhood and adult obesity, not only in developed countries but also in many developing countries.Substantial scientific evidence supports the importance of physical inactivity as a risk factor for NCD independent of poor diet, smoking and alcohol misuse.Physical activity has comprehensive health benefits across the lifespan: It promotes healthy growth and development in children and young people, helps to prevent unhealthy mid-life weight gain, and is important for healthy ageing, improving and maintaining quality of life and independence in older adults.The most recent global estimates indicate that 60% of the world population are exposed to health risks due to inactivity. 2 Increasing population-wide participation in physical activity is a major health priority in most high and middle income countries and is a rapidly-emerging priority in lower income countries experiencing rapid social and economic transitions.
ITALY
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Benzalkonium Chloride
Authors: Carl W. Walter
Journal: JAMA (1962)

<h3>To the Editor:—</h3> The clinical note "Benzalkonium Chloride—Source of Hospital Infection with Gram-Negative Bacteria" (<i>JAMA</i><b>177</b>:708-710 [Sept. 9] 1961) is erroneously titled. There is no bacteriologic evidence presented in the article that justifies the title. An experiment is recounted in which<i>Pseudomonas achromobacteriaceae,</i>recovered from a patient in the reported series, survived exposure to the solution in which cotton pledgets were submerged for 24 hours. This phenomenon could have been predicted from the literature quoted in the article. There is no evidence that there was any benzalkonium chloride in the solution tested! Disinfection is not magic! Enough agent must be applied to destroy bacteria just as enough digitalis must be administered to secure the desired clinical effect. The essential concentration of germicide is the residual concentration after the bacteria exposed to it have been destroyed. This concept is generally accepted for some germicides but ignored for others. Residual chlorine
Hair transplantation
Authors: Thomas D. Griffin
Journal: Journal of the American Academy of Dermatology (2011)

As a physician who has been performing hair transplantation for 23 years, having first started with 4.5-mm plugs, taught by my mentor—who in turn was taught by Dr Norman Orentreich—and whose technique evolved through the years to what is now considered current technology with follicular unit transplantation, I greatly enjoyed reading Hair Transplantation by Drs Avram and Rogers. The field of hair transplantation has been missing a concise reference text, and Hair Transplantation fills that void.
Matthews' Physicians' Blue-Book. A Complete Medical and Surgical Register of the State of Missouri, containing Lists of Physicians and Surgeons, with School and Year of Graduation, and List of Specialists Classified Alphabetically by Towns. Showing Population. Also the Various Hospitals, Sanitariums, Colleges and Other Institutions, State Board of Health, Societies, Journals, etc., and the Late Medical and Pharmacy Laws, 1901-1902.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Stratification of morbidity and mortality outcome by preoperative risk factors in coronary artery bypass patients. A clinical severity score
Authors: T. L. Higgins
Journal: JAMA (1992)

<h3>Objective.</h3> —To relate morbidity and mortality risk to preoperative severity of illness in patients undergoing coronary artery bypass grafting. <h3>Design.</h3> —Retrospective analysis of 5051 patients using univariate and logistic regression to identify risk factors associated with perioperative morbidity and mortality. Prospective application of models to a subsequent 2-year validation cohort (n=4069). <h3>Setting.</h3> —Cleveland Clinic Foundation. <h3>Patients.</h3> —All adult patients undergoing coronary artery bypass graft surgery between July 1,1986, and June 30,1988 (reference group), and July 1,1988, and June 30, 1990 (validation group). <h3>Main Outcome Measures.</h3> —Mortality and morbidity (myocardial infarction and use of intra-aortic balloon pump, mechanical ventilation for 3 or more days, neurological deficit, oliguric or anuric renal failure, or serious infection). <h3>Main Results.</h3> —Emergency procedure, preoperative serum creatinine levels of greater than 168 μmol/L, severe left ventricular dysfunction, preoperative hematocrit of 0.34, increasing age, chronic pulmonary disease, prior vascular surgery, reoperation, and mitral valve insufficiency were found to be predictive of mortality. In addition to these factors, diabetes mellitus, body weight of 65 kg or more, aortic stenosis, and cerebrovascular disease were predictive of morbidity. Logistic regression equations were developed, and a simple additive score for clinical use was designed by allocating each of these risk-factor values of 1 to 6 points. Both methods predict mortality. Increased morbidity was demonstrated with increases in score. <h3>Conclusions.</h3> —The logistic or clinical models developed are superior to the currently available methods for comparing mortality outcome and provide previously unavailable information on morbidity based on preoperative status. The clinical scoring system is useful for preoperative estimates of morbidity and mortality risks. (<i>JAMA</i>. 1992;267:2344-2348)
PATH-08. THE PROGNOSTIC VALUE OF A NOVEL QUANTITATIVE MGMT PROMOTER METHYLATION SCORE FOR PATIENTS WITH GLIOBLASTOMA
Authors: Akshay Ravi, Annette Molinaro, Seunggu J Han, Farid Chehab, Mitchel S Berger, Nicholas Butowski
Journal: Neuro-Oncology (2017)

Methylation status of the O 6-methylguanine–DNA methyltransferase (MGMT) gene promoter is a well-known prognostic marker in glioblastoma, with prior studies demonstrating that methylated MGMT promoter corresponds to increased overall survival (OS) and progression free survival (PFS). MGMT promoter methylation scores have since emerged as a method of more precisely quantifying degree of methylation thereby improving its prognostic potential on these outcomes. Using bisulfite sequencing, we have developed a 17 point MGMT promoter methylation index, based on the number of methylated CpG sites. In a retrospective review of 180 patients with newly diagnosed glioblastoma, we evaluated the predictive value of this scoring index compared to a binary MGMT promoter methylation status for both PFS and OS. Increasing MGMT methylation score was predictive of longer PFS and OS in multivariate models built along established prognostic variables, respectively (HR 0.93 [0.88, 0.98], HR 0.91 [0.86,0.97]). Brier score and ten fold cross validation revealed lower predictive error for both outcomes when using MGMT index compared to MGMT status. A partDSA model was used to risk stratify patients using MGMT score, age, extent of resection (EOR), and Karnofsky Performance Status (KPS), resulting in two partition groups for PFS, and three partition groups for OS. The MGMT promoter methylation index provides a quantitative representation of the extent of methylation in the MGMT promoter. PFS and OS models support the MGMT index as a valid and superior prognostic marker compared to traditional MGMT methylation status, particularly with regards to weakly methylated or "gray area" cases. We propose a new model to stratify patients into partition groups based on MGMT score, age, EOR, and KPS that improves accuracy in predicting survival in patients with newly diagnosed glioblastoma.
Journal of Surgical Research, Philadelphia
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Experience with palliative sedation (PS) in an inpatient oncology setting.
Authors: Diogo Bugano Diniz Gomes, Bernard Lobato Prado, Pedro Luiz Serrano Uson Junior, Patricia Taranto, Monique Sedlmaier Franca, Daniel Eiger, RODRIGO COUTINHO MARIANO, David Hui, Auro Del Giglio
Journal: Journal of Clinical Oncology (2016)

e21503 Background: Palliative sedation (PS) is an intervention to treat refractory symptoms and to relieve suffering at the end of life. Its prevalence and practice patterns vary widely. Methods: This is a retrospective study of the use of PS in cancer patients who died at our comprehensive cancer center between March 1st, 2012 and December 31th, 2014. PS was defined as the use of continuous infusion of midazolam or neuroleptics for refractory symptoms as stated in the progress notes. Patients who died in the ICU were excluded. Results: During the study period, 556 cancer patients died at the institution and 203 (36.5%) received PS. Main reasons for exclusion were death in the ICU (168 patients) and no use of midazolam or neuroleptics (77 patients). Patients who received PS as compared to those not sedated were younger (67.8 vs. 71.5 years-old, p = 0.007) and more likely to have a primary diagnosis of lung cancer (23% vs. 15% p < 0.001). Patients receiving PS were more likely to be seen by oncology/hematology rather than other specialties (70% vs 45% p < 0.001) and more likely to have a longer hospital stay from admission to death (47.9 days vs 26.2 days p < 0.001). Only 25 patients (12%) were seen by a dedicated palliative care team. The most common indications for sedation were dyspnea (51.5%) and delirium (19.5%) and the most common dugs used were midazolam (52.9%) or midazolam and a neuroleptic (39.2%). Median initial midazolam infusion rate was 0.75 mg/h (interquartile range – IQR - 0.6-1.5) and final rate was 1.5 mg/h (IQR 0.9-3.0). Median time from sedation to death was 27 hours (IQR 12-58). Conclusions: Palliative sedation is a common practice at our hospital and it is not associated with shortening of hospital stay. Further research is needed to identify factors that may affect the frequency and outcomes associated with palliative sedation.
Treatment of recurrent genital herpes simplex infections with oral acyclovir. A controlled trial
Authors: R. C. Reichman
Journal: JAMA (1984)

Two hundred fifty patients were entered into a multicenter trial to evaluate the efficacy and toxicity of orally administered acyclovir for treatment of recurrent genital herpes. The study consisted of part A, in which patients entered the study within 48 hours of the onset of lesions, and part B, in which patients self-initiated therapy as soon as possible after the onset of a recurrent episode. In both parts, patients received either acyclovir (200 mg) or placebo, five times daily for five days. In both parts, the duration of virus shedding and the time to crusting and healing of lesions were shorter among acyclovir recipients than among placebo recipients. In part B, fewer acyclovir recipients formed new lesions during the study medication period than did placebo recipients. When parts A and B were compared directly, the duration of virus shedding and the times required for crusting and healing of lesions were significantly shorter among acyclovir recipients in part B than among acyclovir recipients in part A. No significant differences in the duration of itching and pain or in the times of subsequent recurrence were noted between acyclovir and placebo groups in either part A or part B. No significant toxic or adverse reactions were seen in acyclovir recipients. Oral acyclovir shortens the duration of virus shedding and the duration of lesions in patients with recurrent genital herpes. These effects are more pronounced when therapy is self-initiated by patients early in the course of a recurrent episode. (<i>JAMA</i>1984;251:2103-2107)
A concentrated therapeutic regimen for vulvovaginal candidiasis
Authors: W. H. Robertson
Journal: JAMA (1980)

Two therapeutic regimens were used to treat vulvovaginal candidiasis with clotrimazole vaginal tablets. The purpose of this study was to compare the efficacy of a three-day double-dose schedule with that of a seven-day single-dose schedule. Both regimens were comparable in eliminating the<i>Candida</i>sp. (<i>JAMA</i>1980;244:2549-2550)