tbuckley/cabot-search huggingface dataset:
Decreases in invasive Haemophilus influenzae diseases in US Army children, 1984 through 1991
Authors: L. E. Broadhurst
Journal: JAMA (1993)

<h3>Objective.</h3> —To document trends in the incidence of invasive<i>Haemophilus influenzae</i>diseases in young children of US Army active duty soldiers following the publication of<i>H influenzae</i>type b immunization recommendations for young children between 1985 and 1990. <h3>Design.</h3> —A population-based surveillance of hospital discharge diagnoses for<i>H influenzae</i>invasive diseases. <h3>Setting.</h3> —Military and civilian medical treatment facilities around the world. <h3>Patients.</h3> —There was a mean population of nearly 200 000 US Army health care beneficiaries younger than 5 years of age each year of the study. <h3>Outcome Measures.</h3> —Annual total and age-specific incidences of the six most common<i>H influenzae</i>invasive diseases in this population (meningitis, epiglottitis, septicemia, pneumonia, cellulitis, and septic arthritis). <h3>Results.</h3> —The annual number of cases of<i>H influenzae</i>invasive diseases decreased from a high of 188 in 1986 to 43 in 1991. The incidence in the age group at highest risk for<i>H influenzae</i>disease, those 6 to 11 months of age, decreased from 355 per 100 000 children in 1986 to 116 per 100 000 in 1991 (<i>P</i>&lt;.0001 χ<sup>2</sup>for trend). The incidence for<i>H influenzae</i>meningitis declined from 59 per 100 000 children in 1986 to 6 per 100 000 in 1991 (<i>P</i>&lt;.0001, χ<sup>2</sup>for trend). <h3>Conclusions.</h3> —The decrease in<i>H influenzae</i>invasive diseases closely follows the dates of<i>H influenzae</i>type b vaccine licensure for use in progressively younger age groups. Some age groups, however, experienced a decline in disease rates even before becoming eligible for vaccination. (<i>JAMA</i>. 1993;269:227-231)
Abstract 1395: Residual convolutional neural network for predicting response of transarterial chemoembolizationin hepatocellular carcinomafrom CT imaging
Authors: Jie Peng
Journal: Cancer Research (2019)

Abstract Purpose: We aimed to develop and validate a model of deep learning for the preoperative prediction of response of patients with intermediate stage hepatocellular carcinoma undergoing transarterial chemoembolization. Methods: The training and two independent validation CT images were acquired for 540 patients from the Nan Fang Hospital (NFH), 84 patients from Zhu Hai Hospital Affiliated with Jinan University (ZHHAJU) and 136 patients from the Sun Yat-sen University Cancer Center (SYUCC). We built a predictive model from the outputs using transfer learning techniques of a residual convolutional neural network (ResNet50). Then, we revaluated the prediction accuracy for each patch in two independent validation cohorts. Results: In the training (NFH) set, the deep learning model had a high accuracy of 84.3% and an areas under the receiver operating characteristic curves (AUROC) of 0.97, 0.96, 0.95 and 0.96 for complete response (CR), partial response (PR), stable disease (SD) and progressive disease (PD), respectively. In the validation (ZHHAJU) set, the deep learning model had an accuracy of 85.1% and an AUROC of 0.98, 0.96, 0.95 and 0.94 for CR, PR, SD and PD, respectively. In the other validation (SYUCC) set, the deep learning model had an accuracy of 82.8% and an AUROC of 0.97, 0.96, 0.95 and 0.95 for CR, PR, SD and PD, respectively. Conclusion: The proposed ResNet model showed excellent performance for the individualized and non-invasive estimation of TACE therapy, which may help clinicians to better identify patients with HCC who can benefit from the interventional treatment. Citation Format: Jie Peng. Residual convolutional neural network for predicting response of transarterial chemoembolizationin hepatocellular carcinomafrom CT imaging [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1395.
Abstract 530: Is Severe Hypertriglyceridemia (&gt; 1000 mg/dl) a Risk Factor for Atherosclerosis ?
Authors: Katharina Gafinen, Andreas Hoerger, Annette Hauenschild, Heike Kantner, Hans Kloer
Journal: Circulation (2007)

Severe Hypertriglyceridemia (SHTG) is believed to be a rare condition difficult to treat, but associated with a relatively low risk of morbidity, except for pancreatitis. In particular, SHTG is not believe to be a risk factor of atherosclerosis . Therefore, we performed a morbidity survey of SHTG patients being followed up for at least 2 years in the lipid clinics of the German Working Group. Evaluation of co-morbid conditions was based on patient chart review. The data of 893 SHTG cases (689 males (m), 204 females (f)) were compiled. As an admission criterion to the study SHTG patients had to have a documented TG &gt; 1000 mg/dl prior to follow-up in the respective lipid clinics. Mean age was 50 ± 12 years, mean BMI was 28.7 ± 4.5. Upon admission to the lipid clinics mean TG was 2800 mg/dl (1000 – 16 000 mg/dl) and mean TC was 480 mg/dl (162–15920 mg/dl). Even after long term treatment in the lipid clinics mean TG and TC were still highly elevated (1190mg/dl and 322mg/dl, respectively). Regarding co-morbid conditions the following prevalence data were obtained: episodes of pancreatitis 24% (21% m,35%f), gallstones 21% (17% m, 32% f),hypertension 70%, diabetes 51 %, hyperuricemia 72 %. The prevalence of clinical manifestations of CVD was as follows : CHD by angiography 24% (27% m , 16 % f), MI 14 % (16% m, 5% f) , angina 21% (23% m, 17% f), PVD 15 % (14% m, 17% f), cerebrovascular disease 20 % (19% m, 24% f ). A total of 36 % of all SHTG patients (37% m, 33% f) showed at least one clinical manifestation of atherosclerotic cardiovascular disease. After excluding other risk factors 19% of remaining SHTG cases (20% m, 16 % f) still had clinical CVD. In conclusion, we were able to demonstrate a significant CVD burden in both male and female SHTG patients. SHTG itself seems to be an independent CVD risk factor.
Notes on Books
Journal: BMJ (1888)

THE BRIT1SH MDCA JOUBNU,AL 823 be disposed of in a few mintutes, but maniy requiring several hours for their successful performance); buit it is easy to select andl eliminate in such a way as to vary the illustrations and exer- cises given each year, and for suich a purpose these outliines afford an admirable store, quite free, we think, from impracticable experiments too often recommended by stay-at-lome travellers in
Digitalis effects on exercise test
Authors: J. Y. Bradfield
Journal: JAMA (1971)

<h3>To the Editor.—</h3> Hashish smoked by American soldiers in West Germany is relatively free of contamination. At the US Army Crime Laboratory in Frankfurt, West Germany, serveral dozen confiscated hashish samples are analyzed each week. Only 2% to 3% are found to be adulterated—usually with codeine, morphine, spices, opium, or feces. The samples contain 5% to 10% tetrahydrocannabinol (THC). Bronchitis and upper respiratory tract ailments in hashish smokers are being observed with daily frequency by US Army physicians in West Germany. Since publication of our original observations, we have studied an additional 22 bronchitic young soldiers who smoked at least 50 gm of hashish monthly for 3 to 12 months. These patients all demonstrate a decreased vital capacity ranging from 15% to 40% below normal. Discontinuation of hashish smoking for one week improves vital capacity in some patients but not others. It is difficult to study respiratory diseases in hashish
Outlines of Rural Hygiene.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nitric oxide mediates lipopolysaccharide-induced alteration of mitochondrial function in cultured hepatocytes and isolated perfused liver
Authors: I Kurose
Journal: Hepatology (1993)

The influence of endogenous nitric oxide, which is generated by stimulation with lipopolysaccharide, on the mitochondrial energization of rat hepatocytes was investigated in vitro and ex vivo. Using a fluorescence microscope equipped with a silicon intensifier target camera, we visualized fluorescence of rhodamine-123, a mitochondrial energization–sensitive fluorescence probe, in individual hepatocytes and measured the fluorescence intensity with a digital imaging processor. Although addition of Kupffer cells or lipopolysaccharide in a range of 0.1 to 1.0 νg/ml caused no significant alteration in the fluorescence in hepatocytes, Kupffer cells plus 1.0 μg/ml lipopolysaccharide reduced fluorescence intensity in the cocultured hepatocytes. The alteration of rhodamine-123 fluorescence in the hepatocytes induced by lipopolysaccharide-activated Kupffer cells was significantly inhibited by the addition of NG-monomethyl-L-arginine, a selective inhibitor of nitric oxide synthesis. The transportal infusion of lipopolysaccharide also decreased rhodamine-123 fluorescence in perfused rat liver. The decrease was significantly enhanced in the pericentral regions. Autofluorescence of NADH was elicited by continuous infusion of lipopolysaccharide; this reaction was also enhanced in the pericentral regions. We showed the main site of uptake of infused lipopolysaccharide in the hepatic lobule to be in the periportal regions with fluorescein isothiocyanate–labeled lipopolysaccharide. Our results indicate that the inhibition of mitochondrial energization occurs mainly in pericentral regions, which are distant from the lipopolysaccharide uptake site. The continuous administration of NG-monomethyl-L-arginine significantly attenuated the lipopolysaccharide-induced decrease in rhodamine-123 fluorescence and increase of the NADH contents of the hepatic lobule. These results suggest that nitric oxide mediates the lipopolysaccharide-activated, Kupffer cell–induced inhibition of mitochondrial electron transport in hepatocytes. (HEPATOLOGY 1993;18:380–388).
Ethylene Glycol Monoethyl Ether and Ethylene Glycol Monoethyl Ether Acetate Teratology Studies
Authors: J. E. Doe
Journal: Environmental Health Perspectives (1984)

An inhalation teratology study was conducted in rats at 10, 50 and 250 ppm ethylene glycol monoethyl ether (EGEE) and in rabbits at 10, 50 and 175 ppm EGEE. This study was designed to supplement a study conducted for NIOSH which showed teratogenic effects in rats at 200 ppm EGEE and in rabbits at about 160 ppm EE. In this study, EGEE was found not to cause teratogenic effects at concentrations up to and including 250 ppm in rats and 50 ppm in rabbits, while 175 ppm EGEE was considered to be a marginal effect level for teratogenic effects in rabbits. Fetotoxicity was observed at 250 ppm EGEE and possibly at 50 ppm EGEE in rats. An inhalation teratology study using ethylene glycol monoethyl ether acetate (EGEEA) has been conducted in rabbits at 25, 100 and 400 ppm. There was evidence of teratogenicity (vertebral malformations) at 400 ppm EGEEA and slight fetotoxicity at 100 ppm; 25 ppm was a no effect level.
SERUM ACYLCARNITINE CONCENTRATION IS ELEVATED IN PATIENTS WITH ACUTE DECOMPENSATED HEART FAILURE
Authors: Takeo Fujino, Koichiro Kinugawa, Daisuke Nitta, Teruhiko Imamura, Hironori Muraoka, Shun Minatsuki, Toshiro Inaba, Hisataka Maki, Masaru Hatano, Atsushi Yao, Issei Komuro
Journal: Journal of the American College of Cardiology (2015)
Amer Journal of Medical Electronics, New York
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Is Fulminant Viral Hepatitis a Systemic Disease?
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Issues in employee drug testing. Council on Scientific Affairs
Journal: JAMA (1987)

This report on employee drug and alcohol screening, adopted by the American Medical Association's House of Delegates at the 1987 annual meeting, reflects the views of the scientific literature as of February 1987 and is not intended to serve as a standard of medical care. It addresses constitutional, statutory, and common law issues involving privacy, discrimination, and public safety in employer-employee relations and in peer programs for impaired physicians. The Council recommends that the AMA reaffirm its commitment to education on the scientific issues of drug testing; monitor legal issues, especially those involving employment discrimination; and support drug and alcohol screening limited to (1) employees whose jobs affect the health and safety of others, (2) employees who are reasonably suspected of impaired job performance related to substance abuse, and (3) employees in comprehensive treatment and rehabilitation programs.
Correction: Screening for congenital hypothyroidism in the Republic of Ireland
Authors: G Jones, D Owens, K Jones, M Hayes
Journal: BMJ (1981)

CorrectionScreening for congenital hypothyroidism in the Republic of Ireland Several errors occurred in this paper by Sylvia Dockeray et al (6 December 1980, p 1519).Under Protocol in the materials and methods section 1251I should read 1231; the dose of 99mTc is from 50 to 100 ,uCi and the irradiation dose to the thyroid is from 7 to 220 mR, while that to an infant's thyroid during anteroposterior chest radiography is 50 mR or less.
Figshift
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medical abortion.
Authors: J. Barnard, A. Ulmann
Journal: BMJ (1992)

need for long term follow up to determine whether the entity that they have defined represents an early manifestation of dementia or a benign if inconvenient consequence of growing old.'The National Institute of Mental Health's working group of which they were members published its criteria in 1986,3 and yet six years later we still do not know the answer.This information is of more than academic interest as it is bound to affect the risk:benefit ratio of any drug advocated to improve memory in elderly people.Crook and Ferris argue by analogy to presbyopia and its correction by means of lenses.A closer parallel might be the decline in physical prowess with age and its boosting with hormones.Both analogies are likely to be imperfect, and the issue is complex and unlikely to be resolved in the current state of knowledge.We do not automatically oppose the investigation of drugs to improve memory.What we want is more information about the baseline so that a more informed judgment may be made about the risks and benefits of their use.
Chloroquine Suppresses Skin Cancers —For a While
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Is ultraviolet exposure acquired at work the most important risk factor for cutaneous squamous cell carcinoma? Results of the population-based case-control study FB-181
Authors: J. Schmitt, E. Haufe, F. Trautmann, H.-J. Schulze, P. Elsner, H. Drexler, A. Bauer, S. Letzel, S.M. John, M. Fartasch, T. Brüning, A. Seidler, S. Dugas-Breit, M. Gina, W. Weistenhöfer, K. Bachmann, I. Bruhn, B.M. Lang, S. Bonness, J.P. Allam, W. Grobe, T. Stange, S. Westerhausen, P. Knuschke, M. Wittlich, T.L. Diepgen
Journal: British Journal of Dermatology (2018)

Squamous cell carcinoma (SCC) is a specific type of skin cancer. It is one of the most common cancers in Europe. SCC therefore causes a significant burden, both for the people affected and also in terms of costs to society. One main cause of SCC is exposure to natural sunlight. SCC can be prevented by avoiding sun exposure. When people go outside, they can protect themselves through clothes (e.g. long sleeves, hat) and using sunscreens. Until now, prevention programs for SCC and other skin cancers have mainly tried to reduce sun exposure during leisure time. However, there are many people working outdoors, e.g. farmers, construction workers and roofers. The role of occupational (work‐related) and leisure‐time sun exposure in causing SCC is still unclear. Our team of physicians and scientists from Germany investigated the association between occupational and leisure‐time sun exposure and the risk of SCC. More than 600 people with SCC were compared to the same number of healthy people without SCC, taking into account their sun exposure in the past. All study participants were medically examined by trained physicians. Lifetime sun exposure in occupation and leisure time was assessed by interviews. The interviews were tested before starting the study to ensure correct results. The study found that people with high levels of sun exposure at work have a 2‐fold risk of SCC. The more sun exposure people had at work, the more likely was the development of SCC. This result is important, as it indicates that sun protection is not only necessary in leisure‐time, but also at work to prevent skin cancer such as SCC.
Certification of Poliomyelitis Eradication--Western Pacific Region, October 2000
Journal: JAMA (2001)

On October 29, 2000, the Regional Commission for the Certification of Poliomyelitis Eradication certified that the Western Pacific Region (WPR) of the World Health Organization (WHO) is free of indigenous wild poliovirus transmission. The last known case of indigenous poliovirus transmission occurred in Cambodia in March 1997 in a 15-month-old girl. WPR is the second of the six WHO regions to be certified as poliomyelitis-free; the first was the Region of the Americas in 1994. WPR comprises 37 countries and territories (Figure 1) with an estimated 1.6 billion persons (27% of the world's population).