tbuckley/cabot-search huggingface dataset:
Adding Noninsulin Antidiabetic Drugs to Metformin Therapy for Type 2 Diabetes
Authors: Helena W. Rodbard, Paul S. Jellinger
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
No turning back: a blueprint for residency reform
Authors: T. B. McCall
Journal: JAMA (1989)

Libby Zion's death<sup>1</sup>has changed residency training forever. The public is outraged that life-and-death decisions are made by residents working 36-hour shifts and 100-hour weeks. The medical community debates the merits of the present system, but the general public overwhelmingly disapproves of it and expects residency reform. Residents, too, are demanding changes. The ill effects on their lives<sup>2-5</sup>are apparent, including depression, chronic exhaustion, dissatisfaction with personal life, substance abuse, cynicism, and marital problems. Increasingly, concern about life-style is leading talented individuals to forgo medical careers. Even prestigious residency programs are having difficulty attracting qualified applicants.<sup>4</sup> Another spur to residency reform is the threat of malpractice liability. The public believes that long working hours and sleep deprivation harm patient care. Hospitals that continue to overwork residents can expect lawsuits alleging that tired residents provided poor care. Teaching hospitals could pay multimillion dollar settlements. Change in residency training
COMPARISON OF MURINE ABSCESS AND TUMOR UPTAKE OF SMALL UNILAMELLAR VESICLES (SUVs).
Authors: Lawrence E. Williams, K. R. Patel, George W. Tin, Richard T. Proffitt, John D. Baldeschwieler
Journal: Clinical Nuclear Medicine (1983)

Williams, Lawrence E.; Patel, K. R.; Tin, George W.; Proffitt, Richard T.; Baldeschwieler, John D. Author Information
Hospital Care and Medical Utilization After Discharge
Authors: David M. Mitchell
Journal: Annals of Internal Medicine (2011)

Letters15 November 2011Hospital Care and Medical Utilization After DischargeDavid M. Mitchell, MD, PhDDavid M. Mitchell, MD, PhDFrom Sibley Memorial Hospital, Washington, DC 20016.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-155-10-201111150-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Kuo and Goodwin's article (1) suggesting possible cost shifting due to hospitalist-based care strikes at the core of what it means to be a hospitalist. However, I am concerned that the authors draw too many generalizations from these otherwise valuable results.First, as a physician who has worked as a hospitalist in 7 states and 12 hospitals over 10 years, I think that readers must recognize that hospitalist groups are very heterogeneous and that such broad-based results are weakest in that they cannot evaluate variability among individual hospitalist groups. Variability of practice patterns within individual medical specialties ...Reference1. Kuo YF, Goodwin JS. Association of hospitalist care with medical utilization after discharge: evidence of cost shift from a cohort study. Ann Intern Med. 2011;155:152-9. [PMID: 21810708] LinkGoogle Scholar Author, Article, and Disclosure InformationAuthors: David M. Mitchell, MD, PhDAffiliations: From Sibley Memorial Hospital, Washington, DC 20016.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAssociation of Hospitalist Care With Medical Utilization After Discharge: Evidence of Cost Shift From a Cohort Study Yong-Fang Kuo and James S. Goodwin Hospital Care and Medical Utilization After Discharge David O. Meltzer and Jeanette W. Chung Hospital Care and Medical Utilization After Discharge Jean-Sebastien Rachoin Hospital Care and Medical Utilization After Discharge Daniel J. Brotman , Romsai T. Boonyasai , and Amy Deutschendorf Hospital Care and Medical Utilization After Discharge Arun K. Raman Hospital Care and Medical Utilization After Discharge Dimitriy Levin and Jeffrey J. Glasheen Hospital Care and Medical Utilization After Discharge Joshua Freeman Hospital Care and Medical Utilization After Discharge Yong-Fang Kuo and James S. Goodwin Metrics 15 November 2011Volume 155, Issue 10Page: 719KeywordsHospital medicineHospitalistsInpatientsMedicareNursing homesOutpatient clinicsPatientsPopulation statisticsPrimary care physiciansStatistical data ePublished: 15 November 2011 Issue Published: 15 November 2011 Copyright & PermissionsCopyright © 2011 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Gene Protects Kidneys
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Meet the First Authors
Authors: Stefano Spolitu
Journal: Circulation Research (2019)

During his PhD studies, in the lab of Dr Barbara Batetta, he investigated the role of cholesterol ester (CE) metabolism in inflammation and malignant cell proliferation and he demonstrated that high CE storage and low HDL levels observed in cancer, infections, and atherosclerosis are closely related to the peculiar biology of immune and cancer cells.As part of his graduate work, he spent 1 year in the laboratory of Dr Ira Tabas at Columbia University, where he studied the signaling pathways and mechanisms underlying the protective actions of endogenous specialized proresolving mediators and how proresolution pathways can be exploited for atherosclerosis treatment.His current work in the laboratory of Dr Ozcan focuses on investigating the role of hepatic glucagon receptor signaling in the regulation of PCSK9 and lipid metabolism.He elucidated the new downstream pathway of glucagon/cAMP signaling involving Epac2/Rap1a mediators in the protein downregulation of PCSK9.Outside of the laboratory, he loves spending his free time drawing, listening to music, and watching Juventus' soccer games.(This makes the Editor-in-Chief, who is also a staunch Juventus fan, very happy!)
A Reevaluation of Cancer Incidence near the Three Mile Island Nuclear Plant: The Collision of Evidence and Assumptions
Authors: Steve Wing, David Richardson, Donna Armstrong, Douglas Crawford-Brown
Journal: Environmental Health Perspectives (1997)

Previous studies concluded that there was no evidence that the 1979 nuclear accident at Three Mile Island (TMI) affected cancer incidence in the surrounding area; however, there were logical and methodological problems in earlier reports that led us to reconsider data previously collected. A 10-mile area around TMI was divided into 69 study tracts, which were assigned radiation dose estimates based on radiation reading and models of atmospheric dispersion. Incident cancers from 1975 to 1985 were ascertained from hospital records and assigned to study tracts. Associations between accident doses and incidence rates of leukemia, lung cancer, and all cancer were assessed using relative dose estimates calculated by the earlier investigators. Adjustments were made for age, sex, socioeconomic characteristics, and preaccident variation in incidence. Considering a 2-year latency, the estimated percent increase per dose unit +/- standard error was 0.020 +/- 0.012 for all cancer, 0.082 +/- 0.032 for lung cancer, and 0.116 +/- 0.067 for leukemia. Adjustment for socioeconomic variables increased the estimates to 0.034 +/- 0.013, 0.103 +/- 0.035, and 0.139 +/- 0.073 for all cancer, lung cancer, and leukemia, respectively. Associations were generally larger considering a 5-year latency, but were based on smaller numbers of cases. Results support the hypothesis that radiation doses are related to increased cancer incidence around TMI. The analysis avoids medical detection bias, but suffers from inaccurate dose classification; therefore, results may underestimate the magnitude of the association between radiation and cancer incidence. These associations would not be expected, based on previous estimates of near-background levels of radiation exposure following the accident.
抓挠的习惯消除治疗对异位性皮炎儿童患者的积极影响:一项随机对照研究
Authors: P. Norén, L. Hagströmer, M. Alimohammadi, L. Melin
Journal: British Journal of Dermatology (2018)

瘙痒是湿疹的主要症状,包括常见于儿童的异位性皮炎。人们在感到瘙痒时通常会抓挠皮肤,但这只能暂时缓解,而抓挠可能会导致皮肤损伤和感染。对成人患者的研究表明,减少抓挠可缓解炎症并改善皮肤的愈合,因此减少抓挠的方法对湿疹患者来说大有益处。科学家们发现,抓挠对瘙痒的早期缓解会加强这一行为,从而发展成习惯或强迫行为。不久之后,抓挠习惯就会变成无意识的自动行为了。这意味着,大量的抓挠行为已经变成习惯,而不是对瘙痒的直接反应。减少成人的习惯性抓挠行为的一种方法称为习惯消除治疗,而本项研究旨在调查适用于家长及其孩子的习惯消除治疗结合强力类固醇药膏(湿疹的常见疗法)是否能改善儿童的抓挠和湿疹治疗效果(与单用类固醇相比)。主要结果(表示如何衡量治疗的成功性)是一种称为SCORAD的打分体系,关注于湿疹的严重性;次要结果为CDLQI分数,是一种关注于生活质量的调查表(分数越低表示对生活质量的负面影响越少)。采用习惯消除(HR)方法治疗抓挠行为并结合强力类固醇药膏治疗3周和11周后,研究人员发现SCORAD和CDLQI分数都有显著提高。
Medical care in a Free Community Clinic
Authors: L. P. Schacter
Journal: JAMA (1977)

IN THE 1960s a number of "free clinics" were developed in various North American cities.<sup>1</sup>These clinics had the common objective of providing medical care and counseling in an atmosphere different from the practitioner's office, hospital clinic, or university dispensary. Usually organized by young physicians and health care activists, they were free in the sense of charging little or nothing for their services; using the word in another sense, they were free of the usual structure of health care provision. An attempt was made in these clinics to keep the patient and the patient's needs paramount, to minimize paper work and bureaucracy, and to make the physician a member rather than director of the health team. Particular emphasis was placed on avoiding judgmental attitudes about venereal disease, pregnancy, birth control, or drug use, and on providing patient education in all these areas. The free clinics were in large part
Life and times of the impact factor: retrospective analysis of trends for seven medical journals (1994-2005) and their Editors' views
Authors: M. Chew, E. V Villanueva, M. B Van Der Weyden
Journal: Journal of the Royal Society of Medicine (2007)

Main outcome measures IFs and component numerator and denominator data for the seven general medical journals (1994 to 2005) were collected.IFs are calculated using the formula:(Citations in year z to articles published in years x and y) / (Number of citable articles published in years x and y), where z is the current year and x and y are the previous two years.Editors' views on factors that had affected their journals' IFs were also obtained.Results IFs generally rose over the 12-year period, with the N Engl J Med having the highest IF throughout.However, percentage rises in IF relative to the baseline year of 1994 were greatest for CMAJ (about 500%) and JAMA (260%).Numerators for most journals tended to rise over this period, while denominators tended to be stable or to fall, although not always in a linear fashion.Nine of ten eligible editors were interviewed.Possible reasons given for rises in citation counts included: active recruitment of high-impact articles by courting researchers; offering authors better services; boosting the journal's media profile; more careful article selection; and increases in article citations.Most felt that going online had not affected citations.Most had no deliberate policy to publish fewer articles (lowering the IF denominator), which was sometimes the unintended result of other editorial policies.The two Editors who deliberately published fewer articles did so as they realized IFs were important to authors.Concerns about the accuracy of ISI counting for the IF denominator prompted some to routinely check their IF data with ISI.All Editors had mixed feelings about using IFs to evaluate journals and academics, and mentioned the tension between aiming to improve IFs and 'keeping their constituents [clinicians] happy.' Conclusions IFs of the journals studied rose in the 12-year period due to rising numerators and/or falling denominators, to varying extents.Journal Editors perceived that this occurred for various reasons, including deliberate editorial practices.The vulnerability of the IF to editorial manipulation and Editors' dissatisfaction with it as the sole measure of journal quality lend weight to the need for complementary measures.
Buying Editorials
Authors: T A Brennan
Journal: New England Journal of Medicine (1994)

Editorials in medical journals are typically dispassionate, carefully written critiques of new research, often with just the right amount of background to place matters of uncertainty in context. The statements made in an editorial imply an informed, objective view that engenders trust. I am no doubt one of many whose approach to specific clinical problems is sometimes informed by the opinions expressed in editorials.In that light, I was recently surprised to receive a call from a representative of Edelman Medical Communications, a public-relations firm in New York, asking whether I would be interested in writing an editorial for a . . .
Office Gynecology
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Persistent sex differences in growth control of early rat liver lesions are programmed during promotion in the resistant hepatocyte model
Authors: D Liao
Journal: Hepatology (1996)

The effects of gonadal hormones on several parameters associated with sex-differentiated promotion in the resistant hepatocyte (RH) model were studied. Male and female rats were initiated with diethylnitrosamine and promoted with 2-acetylaminofluorene (2-AAF) and partial hepatectomy [correction of hepatecomy] (PH). Before promotion, some female rats were ovariectomized, with or without receiving subcutaneous testosterone implants. Rats were killed either at the time of cessation of 2-AAF treatment or 2 weeks later. Ovariectomy decreased the messenger RNA (mRNA) expression of the female-specific cytochrome P450 2C12 (CYP2C12) at the time of PH, but did not increase the male-specific CYP2C11. Testosterone treatment further decreased CYP2C12 and induced CYP2C11 to the level in male liver. Hepatic foci positive for the placental form of glutathione-S-transferase (GST-P) were larger in male than in female rats. Ovariectomy did not affect the size of foci, whereas testosterone treatment increased the size to the male level. At the time of cessation of 2-AAF treatment, the labeling index, determined as cells staining for proliferating cell nuclear antigen, was higher in foci of males and testosterone-treated females than in foci from females with or without ovariectomy, whereas the labeling index in the surrounding hepatocytes was lower in males and testosterone-treated females. Two weeks later, the sex differences in labeling index were still present in foci, but no differences were observed in the surrounding hepatocytes. An elevated c-myc expression was observed in nodules isolated 3 weeks after PH from males and testosterone-treated females, but not in nodules from intact females. In conclusion, ovarian hormones did not affect promotion in the RH-model, whereas testosterone administration to ovariectomized females masculinized growth hormone-regulated hepatic parameters and response to promotion. The persistent sex differentiation in focal proliferation and c-myc expression indicated that a hormone-regulated change in growth control was introduced during 2-AAF/PH treatment.
BOOK REVIEWS
Authors: D. J.-A. MUNDERLON
Journal: JNCI Journal of the National Cancer Institute (1992)

Journal Article BOOK REVIEWS Get access Bone Marrow Transplantation: Principles, Practice, and Nursing Insights Marie Bakitas Whedon , ed. Boston : Jones and Bartlett Publ. , 1991 . 462 pp., illus. $50 D. JO-ANN MUNDERLON, R.N., B.S.N., M.A.S. D. JO-ANN MUNDERLON, R.N., B.S.N., M.A.S. Bone Marrow Transplantation Program, The Johns Hopkins Hospital Oncology Center600 N. Wolfe St. Baltimore, MD 21205 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 84, Issue 16, 19 August 1992, Page 1284, https://doi.org/10.1093/jnci/84.16.1284 Published: 19 August 1992
Interleukin-15 restores the reactivity of the peripheral memory-like pool in the exhausted hepatitis B virus-specific CD8+ T cell population during persistent HBeAg(-) infection
Authors: Julia Peña Asensio, Eduardo Sanz-de Villalobos, Joaquín Míquel, Alejandro González Praetorius, Juan Ramón Larrubia
Journal: Journal of Hepatology (2020)
Three Lectures ON CONTRACTED PELVIS: Delivered in the University of London, for Advanced Students
Authors: G. Fitzgibbon
Journal: BMJ (1924)

CONTRACTED PELVIS. it = naLBJshown that the amount of megaloblastic marrow varies from time to time during the disease, but has certainly not shown that there is no such specific change.There is one other point of difference between pernicious anaemia and all other anaemias which should be mentioned.The occurrence of another severe disease during the gourse of pernicious anaemia partly or completely obliterates the typical blood picture; this is well illustrated by Weinberg'{ case.The secondary anaemias are intensified by the advent of intercurrent disease.-
Does Coronary Artery Bypass Grafting Alone Correct Moderate Ischemic Mitral Regurgitation?
Authors: Lishan Aklog, Farzan Filsoufi, Kathryn Q. Flores, Raymond H. Chen, Lawrence H. Cohn, Nadia S. Nathan, John G. Byrne, David H. Adams
Journal: Circulation (2001)

Background The optimal management of moderate (3+ on a scale of 0 to 4+) ischemic mitral regurgitation (MR) remains controversial. Some advocate CABG alone, whereas others favor concomitant mitral annuloplasty. To clarify the optimal management of these patients, we evaluated the early impact of isolated CABG on moderate ischemic MR. Methods and Results Between January 1992 and August 1999, 136 patients (54% male, mean age 70.5 years, mean New York Heart Association class 2.7, mean ejection fraction 38.1%) with a preoperative diagnosis of moderate ischemic MR, without leaflet prolapse or pathology, underwent isolated CABG. Thirty-eight (28%) of 136 patients had intraoperative transesophageal echocardiography (TEE) before CABG, and 68 (50%) had postoperative transthoracic echocardiography (TTE) within 6 weeks of surgery. The subgroups of patients undergoing intraoperative TEE and postoperative TTE had preoperative characteristics similar to the overall group. The 30-day operative mortality was 2.9% ( \batchmode \documentclass[fleqn,10pt,legalpaper]{article} \usepackage{amssymb} \usepackage{amsfonts} \usepackage{amsmath} \pagestyle{empty} \begin{document} \(\frac{4}{136}\) \end{document} ). Intraoperative TEE downgraded the severity of MR to mild or less (0 to 2+) in 89% ( \batchmode \documentclass[fleqn,10pt,legalpaper]{article} \usepackage{amssymb} \usepackage{amsfonts} \usepackage{amsmath} \pagestyle{empty} \begin{document} \(\frac{34}{38}\) \end{document} ). On postoperative TTE, 40% ( \batchmode \documentclass[fleqn,10pt,legalpaper]{article} \usepackage{amssymb} \usepackage{amsfonts} \usepackage{amsmath} \pagestyle{empty} \begin{document} \(\frac{27}{68}\) \end{document} ) continued to have at least moderate MR (3 to 4+), 51% ( \batchmode \documentclass[fleqn,10pt,legalpaper]{article} \usepackage{amssymb} \usepackage{amsfonts} \usepackage{amsmath} \pagestyle{empty} \begin{document} \(\frac{35}{68}\) \end{document} ) improved somewhat to mild (2+) MR, and only 9% ( \batchmode \documentclass[fleqn,10pt,legalpaper]{article} \usepackage{amssymb} \usepackage{amsfonts} \usepackage{amsmath} \pagestyle{empty} \begin{document} \(\frac{6}{68}\) \end{document} ) had resolution of their MR (0 to 1+). The mean preoperative, intraoperative, and postoperative MR grades were 3.0±0.0, 1.4±1.0, and 2.3±0.8, respectively ( P &lt;0.001). Conclusions CABG alone for moderate ischemic MR leaves many patients with significant residual MR and may not be the optimal therapy for most patients. Intraoperative TEE may significantly underestimate the severity of ischemic MR. A preoperative diagnosis of moderate MR may warrant concomitant mitral annuloplasty.
Reply to Andrew J. Portis and Matthew F. Bultitude's Letter to the Editor re: Zhangqun Ye, Guohua Zeng, Huan Yang, et al. Efficacy and Safety of Tamsulosin in Medical Expulsive Therapy for Distal Ureteral Stones with Renal Colic: A Multicenter, Randomized, Double-blind, Placebo-controlled Trial. Eur Urol 2018;73:385–91
Authors: Zhangqun Ye, Guohua Zeng, Zhiqiang Chen, Hua Xu
Journal: European Urology (2018)
Transsynaptic Control of Gene Expression
Authors: M. Robert C. Armstrong and Marc R.
Journal: Annual Review of Neuroscience (1993)

The brain's default mode network consists of discrete, bilateral and symmetrical cortical areas, in the medial and lateral parietal, medial prefrontal, and medial and lateral temporal cortices of the human, nonhuman primate, cat, and rodent brains. Its ...Read More