tbuckley/cabot-search huggingface dataset:
Viral Burden and Disease Progression in HIV‐1–Infected Patients with Sickle Cell Anemia
Authors: Omar Bagasra, Robert M. Steiner, Samir K. Ballas, Oswaldo Castro, Geethanjali Dornadula, Stephen Embury, Donald Jungkind, Lisa Bobroski, Abdullah Kutlar, Sandra Burchott
Journal: American Journal of Hematology (1998)

The spleen and lymph nodes are major sites of human immunodeficiency virus type 1 (HIV-1) replication, mutation, and genetic variation in vivo. If a major portion of the lymphatic tissue, such as the spleen, is removed or otherwise is unavailable for invasion by the HIV-1 virus, will the course of the infection be altered, resulting in a prolonged symptom-free interval or even increased survival? The spleen of most adults with sickle cell anemia (SS) is nonfunctional due to recurrent episodes of microinfarction. If autosplenectomized SS patients are exposed to HIV-1, they may be ideal candidates to examine the question of whether absence of splenic function at the time of infection will positively alter the course of HIV-1-related disease. All SS patients with a diagnosis of HIV-1 infection at five university sickle cell centers were included in the patient cohort. Patients in active treatment or in follow-up (group A, n = 11) underwent a series of quantitative viral studies to determine their HIV-1 viral burden. The studies included the branched-DNA signal amplification assay, quantitative DNA-polymerase chain reaction (PCR), quantitative reverse transcription (RT)-initiated–PCR, and in situ PCR. All patients who died of the complications of the acquired immunodeficiency syndrome (AIDS) or of SS, lost to follow-up, or were otherwise unavailable for study (Group B: n = 7) were included in the total patient group. None of the patients in group B underwent quantitative viral studies. In addition, a control population (group C, n = 36) of HIV-1–infected African Americans without SS, of similar age and gender to the SS patients, were compared with the study population for outcomes. In eight of 11 active patients (group A), the CD4+ T-lymphocyte counts were normal and viral burdens were low for an average of 10.25 years following diagnosis. These eight patients all from group A were the only long-term nonprogressors (44%) among a total of 18 SS patients (groups A and B). In group C (control), only five patients of 36 were long-term nonprogressors (13.9%). Five patients (28%) of the total SS group (groups A and B) succumbed to AIDS. One of the five was from Group A. The evaluation of a limited number of adult individuals suggests that a significant proportion of HIV-1–seropositive SS patients (44%) may be asymptomatic long-term nonprogressors. In these patients, the CD4+ T-lymphocyte counts remained high and their viral burdens were remarkably lower than in non-SS HIV-1–seropositive individuals. Whereas this study does not prove an "autosplenectomy" hypothesis, it suggests that in patients with both SS and HIV-1 infection, the retroviral disease may be ameliorated by host factors of which absence of splenic function prior to HIV-1 infection may be one. Am. J. Hematol. 59:199–207, 1998. © 1998 Wiley-Liss, Inc.
The arrhythmia trainer. A small computer for training in the recognition and electrical treatment of arrhythmias
Authors: A. P. Spivack
Journal: JAMA (1967)

An arrhythmia trainer has been developed to assist in the teaching of arrhythmia pattern recognition and to facilitate practice sessions in the electrical treatment of arrhythmias. This small computerized machine can replace the need for using animal preparations to train the hospital staff in defibrillation. It may also be programmed to teach synchronized defibrillation and external pacing, and it makes daily practice sessions possible. The machine may also be used to record arrhythmias on tape.
Blood Loss After Fractures of the Hip
Authors: Richard C. Gardner
Journal: JAMA (1969)

In ten patients undergoing high femoral trochanteric osteotomy, operative blood loss was measured by radioactive labeling and an automatic blood volume computer. Average blood loss was 1,295 cc, with a range of 500 to 2,650 cc. Average blood loss estimated by the surgeon during the operation was 590 cc. The average percent of preoperative blood volume lost was 25.7% (in females 34.5% and in males 19.8%). Estimates of blood loss by the surgeon were highly underestimated since much of the loss occurred by continued loss of blood in the postoperative period. The results stress the importance of the availability of adequate blood for patients undergoing proximal femoral osteotomy or those with acute trochanteric fractures of the hip.
Endoscopic Tumor Diagnosis and Treatment
Authors: L Aabakken
Journal: Endoscopy (2003)

The abstracts from this year’s Digestive Disease Week (DDW) show that endoscopic is consistently playing a prominent role in current gastroenterology. The topic of tumor diagnosis and treatment overlaps considerably with other review areas - e. g., endoscopic ultrasonography, endoscopic retrograde cholangiopancreatography (ERCP), and colonoscopy. This review therefore focuses on the following topics: enhanced imaging, endoscopic mucosal resection (EMR), and palliative stent therapy.
Digoxin Prescribing
Authors: William H. Carter
Journal: JAMA (1980)

<h3>To the Editor.—</h3> The interesting article "Digoxin-Prescribing: Mostly Good News" by Weintraub et al (242:445, 1979) seems marred by what appears to be an overemphasis on the brand name product of the drug company that sponsored the study. Opinions concerning the complex medical and political issues regarding generic prescribing and bioavailability of "equivalent" drugs should, in our minds, be well separated in scientific publications from important research data about physician-prescribing habits. It is our opinion that the use of generic products made by reputable firms is acceptable practice. (Physicians must work with local pharmacists to ensure that only such products are offered to patients.) In the particular case of digoxin, careful monitoring of clinical response combined with appropriate use of blood levels is essential, regardless of the drug's manufacturer.
OBESITY AND DIABETES
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cost-Effectiveness of Sildenafil
Authors: Kenneth J. Smith, Mark S. Roberts
Journal: Annals of Internal Medicine (2001)

Letters6 February 2001Cost-Effectiveness of SildenafilKenneth J. Smith, MD and Mark S. Roberts, MD, MPPKenneth J. Smith, MDMercy Hospital of Pittsburgh; Pittsburgh, PA 15219 (Smith)University of Pittsburgh School of Medicine; Pittsburgh, PA 15213 (Roberts)Search for more papers by this author and Mark S. Roberts, MD, MPPMercy Hospital of Pittsburgh; Pittsburgh, PA 15219 (Smith)University of Pittsburgh School of Medicine; Pittsburgh, PA 15213 (Roberts)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-134-3-200102060-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Dr. Beaird asserts that health can't be valued. However, values for differing qualities of life can be and are compared, although values can vary greatly between persons or groups. Measuring quality of life is difficult, but this difficulty does not imply that meaningful, individual differences in preferences for health states do not exist, nor does it “prove wrong the assumption of cost-effectiveness analysts.” Instead, it shows that policy informed by cost-effectiveness analyses must account for a wide range of utilities and the uncertainties in their measurement. As we show in our article, sildenafil is reasonably cost-effective compared to ...References1. Volk RJ, Cantor SB, Spann SJ, Cass AR, Cardenas MP, Warren MM. Preferences of husbands and wives for prostate cancer screening. Arch Fam Med. 1997;6:72-6. CrossrefMedlineGoogle Scholar2. Gold MR, Siegel JE, Russell LB, Weinstein MC, eds. Cost-Effectiveness in Health and Medicine. New York: Oxford Univ Pr; 1996. Google Scholar3. Hill SR, Mitchell AS, Henry DA. Problems with the interpretation of pharmacoeconomic analyses: a review of submissions to the Australian Pharmaceutical Benefits Scheme. JAMA. 2000;283:2116-21. CrossrefMedlineGoogle Scholar4. Pauker SG, Kassirer JP. Decision analysis. N Engl J Med. 1987;316:250-8. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Kenneth J. Smith, MD; Mark S. Roberts, MD, MPPAffiliations: Mercy Hospital of Pittsburgh; Pittsburgh, PA 15219 (Smith)University of Pittsburgh School of Medicine; Pittsburgh, PA 15213 (Roberts) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe Cost-Effectiveness of Sildenafil Kenneth J. Smith and Mark S. Roberts Cost-Effectiveness of Sildenafil Jack Beaird Cost-Effectiveness of Sildenafil Peter W. Groeneveld and Bradford W. Duncan Cost-Effectiveness of Sildenafil Richard L. Siegel and Dale B. Glasser Metrics 6 February 2001Volume 134, Issue 3 Page: 250-251 Keywords Clinical trials Erectile dysfunction Health care Morbidity Mortality Population statistics Quality of life ePublished: 6 February 2001 Issue Published: 6 February 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Poly(Vinyl Chloride) Processes and Products
Authors: R. N. Wheeler
Journal: Environmental Health Perspectives (1981)

Poly(vinyl chloride) resins are produced by four basic processes: suspension, emulsion, bulk and solution polymerization. PVC suspensions resins are usually relatively dust-free and granular with varying degrees of particle porosity. PVC emulsion resins are small particle powders containing very little free monomer. Bulk PVC resins are similar to suspension PVC resins, though the particles tend to be more porous. Solution PVC resins are smaller in particle size than suspension PVC with high porosity particles containing essentially no free monomer. The variety of PVC resin products does not lend itself to broad generalizations concerning health hazards. In studying occupational hazards the particular PVC process and the product must be considered and identified in the study.
Reported Cases of Measles—Weeks 45-48, 1992
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Appendix I
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Stress
Authors: Norman Cousins
Journal: JAMA (1979)

The concept of stress is not confined, as is sometimes supposed, to a description of what happens when the human organism is pushed beyond its coping capacity. The stress concept is integrally connected to the concepts of homeostasis and restoration. Homeostasis, as conceived by Walter B. Cannon, MD, is a condition marked by an equilibrium of forces inside the human body. The concept is basically concerned with the workings of the endocrine system, but it also is intended to define a state in which all the elements and factors involved in the proper functioning of the human body are in vital balance with one another. Restoration is the natural drive of the human body to reassert its physical and mental integrity against assault or breakdown. It is natural for the body to right itself, to resist illness, and to overcome disease when it takes hold. The human body has had
Fluoridation of Community Water Systems
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Subcutaneous rheumatoid nodules and serum rheumatoid factor without arthritis
Authors: A. Askari
Journal: JAMA (1974)

SUBCUTANEOUS rheumatoid nodules and serum rheumatoid factor are diagnostic criteria of definite or classic rheumatoid arthritis. They are generally associated with chronic deforming arthritis and severe systemic manifestations of rheumatoid disease. The titer of rheumatoid factor usually parallels disease severity. This study describes a patient with multiple large subcutaneous rheumatoid nodules and high-titer serum rheumatoid factor without arthritis. <h3>Report of a Case</h3> A 56-year-old white man was admitted to University Hospitals of Cleveland on May 25, 1973, with the complaint of lumps in the area of both elbows for five years. These growths first appeared on the left and later on the right elbow as pea-sized growths. The swellings were painless and did not ulcerate or interfere with elbow function. The nodules grew larger and coalesced during the subsequent five years. Medical history disclosed an attack of polyarthralgias without actual swelling 12 years prior to hospital admission. Symptoms were completely
Oligodendroglioma with 35-Year Survival
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
LOCALIZATION OF MUSICAL CENTERS.
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Automotive Sulfate Emission Data
Authors: Joseph H. Somers
Journal: Environmental Health Perspectives (1975)

This paper discusses automotive sulfate emission results obtained by the Office of Mobile Source Air Pollution Control of EPA, General Motors, Ford, Chrysler, and Esso. This work has been directed towards obtaining sulfate emission factors for cars with and without catalyst. While the EPA and Chrysler investigations have found significant sulfate formation in noncatalyst cars, GM, Ford, and Esso have found only trace levels from noncatalyst cars. All of these investigators agree that much higher quantities of sulfate are emitted from catalyst cars. The work done to date shows pelleted catalysts to have much lower sulfate emissions over the low speed-EPA Federal Test Procedures than monolith catalysts. This is probably due to temporary storage of sulfates on the catalyst due to chemical interaction with the alumina pellets. The sulfate compounds are, to a large degree, emitted later under higher speed conditions which result in higher catalyst temperatures which decompose the alumina salt. Future work will be directed towards further elucidation of this storage mechanism as well as determining in detail how factors such as air injection rate and catalyst location affect sulfate emissions.
George Andrew Douglas GordonBasil Sydney GrantJohn Alexander Holden HendersonSadrudin Kassam Mohamed JivaniAndrew Edward Bertie MatthewsStanley Septimus PavillardAlastair Ian RossHelen Mary Slack (née Taylor)Tamirisa Venkateswarlu (“Tom Venkat”)James WatsonBenjamin Weinstein
Journal: BMJ (1997)
Author Index
Authors: Herbert Weiner, Adolf-Ernst Meyer, W. Senf, H. Kordy, M. von Rad, W. Bräutigam, Peter E. Sifneos, Cairns Aitken, Chase Patterson Kimball, Alec Ramsay, Michael von Rad, Johannes Siegrist, Adolf-Ernst Meyer, Herbert Weiner, Adolf-Ernst Meyer, Hubert Speidel, W. Bräutigam, M. von Rad, Adolf-Ernst Meyer, Antje Haag, Christian Müller, Volker Tschuschke, Walter Volk, Reinhard Költzow, Fritz A. Muthny, Adam J. Krakowski, A. Heerlein, G. de la Parra, S. Aronsohn, F. Lolas, W. Ehlers, D. Czogalik, E. Gaus, M. Klingenburg, K. Köhle, Hertha Appelt, Bernhard Strauss, K.W. Bash, Hans-Werner Künsebeck, Wolfgang Lempa, Hellmuth Freyberger, Eike G. Fischer, Nora E. Falke, Antje Haag, Adam J. Krakowski, M.A. Rea, D.H. Hellhammer
Journal: Psychotherapy and Psychosomatics (1984)
Health Savings Accounts
Authors: Mike Mitka
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal