tbuckley/cabot-search huggingface dataset:
Trends in Tuberculosis Incidence—United States, 2006
Journal: JAMA (2007)

In 2006, a total of 13,767 tuberculosis (TB) cases (4.6 per 100,000 population) were reported in the United States, representing a 3.2% decline from the 2005 rate. This report summarizes provisional 2006 TB incidence data from the National TB Surveillance System and describes trends since 1993. The TB rate in 2006 was the lowest recorded since national reporting began in 1953, but the rate of decline has slowed since 2000. The average annual percentage decline in the TB incidence rate decreased from 7.3% per year during 1993-2000 (95% confidence interval [CI] = 6.9%-7.8%) to 3.8% during 2000-2006 (CI = 3.1%-4.5%). Foreign-born persons and racial/ethnic minority populations continue to be affected disproportionately by TB in the United States. In 2006, the TB rate among foreign-born persons in the United States was 9.5 times that of U.S.-born persons. The TB rates among blacks, Asians, and Hispanics were 8.4, 21.2, and 7.6 times higher than rates among whites, respectively. The slowing of the decline in the overall national TB rate and the inability to effectively address persistent disparities in TB rates between U.S.-born and foreign-born persons and between whites and racial/ethnic minority populations threaten progress toward the goal of eliminating TB in the United States. In 1989, CDC and the Advisory Committee for the Elimination of Tuberculosis issued a strategic plan for the elimination of TB, setting an interim target case rate of 3.5 per 100,000 population by 2000 and ultimately the elimination of TB (i.e., <1 case per 1 million population) in the United States by 2010.
Lethal Cascade
Authors: K Wrenn
Journal: Annals of Internal Medicine (1993)

On Being a Doctor1 April 1993Lethal CascadeKeith Wrenn, MDKeith Wrenn, MDVanderbilt University Hospital, Nashville, TN 37232.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-118-7-199304010-00012 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail A physician's anguish over having set in motion a series of events which, despite good intentions, result in the iatrogenic death of a patient.His feet. That's the reason I saw him. They were impressive enough; smelly, swollen, red, pitted, and scaly. Pieces of dirty sock were imbedded in the skin, and cheesy material oozed from between the toes. They stuck out from beneath the sheets and hung over the edge of the stretcher like beacons. They reminded me of pictures of dead people I'd seen in news magazines, but these feet were moving. The toes circumscribed slow arcs back ... Author, Article, and Disclosure InformationAuthors: Keith Wrenn, MDAffiliations: Vanderbilt University Hospital, Nashville, TN 37232.Corresponding Author: Keith Wrenn, MD, Department of Emergency Medicine, Room 1368, Vanderbilt University Hospital, Nashville, TN 37232. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1993Volume 118, Issue 7Page: 562-563KeywordsEmergency departmentFatsNursesSedativesSleepSweatThoraxTouchTriageVital signs ePublished: 15 August 2000 Issue Published: 1 April 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Abstract 1850: Role of microRNAs in circulating tumor cells glutamine metabolism pathways
Authors: Ziwen Zhu, Sarah N. Owen, Abhinav Achreja, Sunitha Nagrath, Deepak Nagrath
Journal: Cancer Research (2019)

Abstract Circulating tumor cells (CTCs) has an important role in the spread of cancers and metastasis. CTCs are believed to be the most promising model to understand metastatic progression in patients with cancer. Glutamine, an alternative carbon source to glucose, has recently been shown to be important for the cancer cell survival, growth and progression. The role of glutamine metabolism in CTCs is not known. MicroRNAs (miRNAs) are a group of highly conserved noncoding RNAs and approximately 22 nucleotides in length. Here, we postulate that CTCs have unique microRNAs (miRNAs) expression compared to resident tumor cells. And miRNAs control CTC glutamine metabolism for the metastasis. In this study, we used 3 primary CTC cultures to study how miRNA controlling glutamine metabolism. We identified several miRNAs have high expressions in CTCs and these miRNAs are regulating glutamine metabolism in CTCs. Our results demonstrate the metabolic miRNA targets of CTCs on cancer progression. These insights will present a unique opportunity for diagnosing and treating cancer through CTCs. Note: This abstract was not presented at the meeting. Citation Format: Ziwen Zhu, Sarah N. Owen, Abhinav Achreja, Sunitha Nagrath, Deepak Nagrath. Role of microRNAs in circulating tumor cells glutamine metabolism pathways [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1850.
Medical News
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Alloplasty in Surgery of the Eye
Authors: William Stone
Journal: New England Journal of Medicine (1958)

THE use of metals and plastics as replacement for function is becoming an important and interesting development in modern surgery. For more than fifteen years, chemically inert materials have been incorporated in various forms in different tissues to perform many functions. It would not be suspected that ophthalmic surgery would be able to share to any degree in this development, mainly because of the size and delicacy of usable structures. But, on the contrary, eye surgery has been among the first to develop a very active interest in the use of alloplastic replacements.Historically, some of the oldest replacement implants . . .
Neuromuscular blockade associated with gentamicin therapy
Authors: W. A. Warner
Journal: JAMA (1971)

Respiratory failure occurred in a patient receiving gentamicin sulfate therapy. Neuromuscular blockade was demonstrated by ulnar nerve stimulation. Partial reversal of hypoventilation was obtained following intravenous administration of calcium. Renal impairment may have caused accumulation of high serum levels of drug, and lowered serum levels of calcium may have facilitated the neuromuscular blocking action of gentamicin.
Fusobacterium necrophorum septicemia
Authors: J. Adams
Journal: JAMA (1983)

<h3>To the Editor.—</h3> We wish to add to the list of serious complications associated with<i>Fusobacterium necrophorum</i>septicemia as reported by Seidenfeld, Sutker, and Luby (1982; 248:11:1348). <h3>Report of a Case.—</h3> A 16-year-old girl was admitted to the hospital was suspected meningitis. Five weeks earlier, she had been seen when results from a slide test for infectious mononucleosis heterophil antibodies were positive. One week before admission, she experienced an upper respiratory tract infection. Two days before admission, she noted thick nasal discharge and a severe, unrelenting headache. At the time of admission, she had moderate nuchal rigidity and a WBC count of 23,600/cu mm. Admission spinal tap and CSF examination findings were unremarkable. Because of increasing nuchal rigidity, a syncopal spell, and a new left-sided Horner's syndrome, the spinal tap was repeated two days later, revealing an elevated CSF WBC count of 830/cu mm, 73% polymorphonuclear leukocytes, and 27% monocytes.
Praktische Gastroenterologie
Authors: Robert J. Stein
Journal: JAMA (1966)

The third edition of this German classic is superb and encyclopedic in its content. Each chapter is complete and up to date. Throughout the book, the practical aspects of gastroenterology are stressed and pertinent bibliographic references are given. The profusion of information is amazing. The book is arranged in a novel manner, and from a clinical point of view it is logical in its organization. The volume begins with general diagnosis and general therapy and then goes on to diseases of the esophagus; differential diagnosis of symptoms of the upper abdomen; position-anomalies of the stomach; peptic ulcer; tumors of the stomach; diffuse gastropathies; the postoperative stomach; duodenum; diseases of the bowel, including the diseases of the small and large intestine, rectum, and anus; diseases of the gallbladder and its passages; diseases of the liver; diseases of the pancreas; and the book concludes with a chapter on symptoms without objective findings.
Phase Ib Study of the Novel Anti-CXCR4 Antibody Ulocuplumab (BMS-936564) in Combination with Lenalidomide Plus Low-Dose Dexamethasone, or with Bortezomib plus Dexamethasone in Subjects with Relapsed or Refractory Multiple Myeloma
Authors: Irene M. Ghobrial, Raymond Perez, Rachid Baz, Paul G. Richardson, Kenneth C. Anderson, Peter Sabbatini, Clifford Dilea, Pina M. Cardarelli, Mark Wade, Guan Xing, Andres Gutierrez, Lewis Cohen, Pamela S. Becker
Journal: Blood (2014)
The Boston Session
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical Connections
Journal: Arthritis & Rheumatology (2020)

Rheumatoid factors (RFs) and anti-citrullinated protein antibodies (ACPAs) are the 2 major autoantibody responses implicated in the pathogenesis of rheumatoid arthritis (RA) and are used for diagnosis.RFs are autoantibodies that bind to other antibodies, specifically to the constant (Fc-) domain of IgG.Assessing how and where different RFs bind their IgG targets could provide insight into their pathogenic properties and improve the clinical value of RF assays.Falkenburg et al designed several IgG targets with a range of amino acid mutations, to which only a specific subset of the RFs that make up the polyclonal RF responses present in patients can bind.The authors used these engineered targets to set up specific RF assays and identified RF reactivity patterns associated with ACPA status and risk of developing arthritis in individuals with arthralgia.RF responses in patients with primary Sjögren's syndrome differed from those found in RA by not binding the tail region of the IgG targets.The targets also provided insight into the pathogenic potential of RFs and RF-ACPA immune complexes (ICs), by showing that the region where immune cell receptors bind IgG is hardly targeted.This suggests that the ACPA IgGs in RF-ACPA ICs may still be able to crosslink Fc receptors and thereby induce proinflammatory responses.
Vector Electrocardiography
Authors: Hohn H. Talbott
Journal: JAMA (1962)

This text is presented as a practical and simplified approach to vector electrocardiography. The introduction is clearly presented. The author has utilized a "motion picture" type of study of instantaneous changes in the vector loop. This technique is imaginative in approach, but fails in execution, because (1) the figures have been made too small, so that the pages must be scrutinized to find minute changes, and (2) although the idea of keeping the leads in spatial orientation is good, the reader must turn his head each time to get things right side up, thus losing the trend. This reviewer was unable to get a clear grasp of the patterns as presented. I think, however, that further work with this method of presentation may prove rewarding.
Author Correction
Journal: Journal of Clinical Oncology (2012)

In the Results section, under "Association of SLCO2B1 SNPs With TTP During ADT," rs12422149AϾG was given in the second sentence, whereas it should have been rs12422149GϾA, as follows: "Three polymorphisms of SLCO2B1, rs12422149G>A (Arg312Gln) in exon 7, rs1789693AϾT in intron 7 and rs1077858AϾG in intron 8, were significantly associated with TTP during ADT in univariate analysis (P ϭ .029,.007,and .009,respectively)."In the Results section, under "Differential DHEAS Uptake of SLCO2B1 Variants," rs12422149AϾG was given in the first paragraph, whereas it should have been rs12422149GϾA, as follows: "To address the biologic function of different SLCO2B1 variants responding to ADT, we investigated the possibility that the SLCO2B1 rs12422149G>A (Arg312Gln) SNP may influence the efficiency of DHEAS transport, thus affecting intracellular levels of androgen and cellular responses to ADT.We chose the SLCO2B1 rs12422149G>A (Arg312Gln) SNP for functional analysis, because it is an exonic SNP, resulting in an amino acid change."In the Results section, under the same subsection, SLCO2B1-312Gln and SLCO2B1-312Arg should have been transposed in the last sentence of the second paragraph and throughout the third paragraph, as follows: "The SLCO2B1-312Arg expressor exhibited a maximal uptake of 223.38 Ϯ 8.55 pmol/mg protein, the SLCO2B1-312Gln expressor exhibited a maximal uptake of 162.76 Ϯ 25.73 pmol/mg protein, and the pCMV6-XL4 vector mock-transfected cells exhibited an uptake of 51.66 Ϯ 7.44 pmol/mg protein.". . .The best-fit K m values for the SLCO2B1-312Arg and SLCO2B1-312Gln variants were 17.65 mol/L (95% CI, 9.303 to 25.99 mol/L) and 13.68 mol/L (95% CI, 4.174 to 23.20 mol/L), respectively.The maximum velocity values for the 312Arg and 312Gln variants were 281.4 pmol/mg protein/min (95% CI, 236.1 to 326.7 pmol/mg protein/min) and 189.5 pmol/mg protein/min (95% CI, 147.8 to 231.2 pmol/mg protein/min).These results indicate that both SLCO2B1 variants can import DHEAS, although the SLCO2B1-312Arg variant exhibits a greater efficiency.We hypothesized that the higher efficiency of the SLCO2B1-312Arg variant in transporting DHEAS into CaP cells leads to a greater ability to activate AR, which may in turn sustain cell growth, thereby explaining why patients with the SLCO2B1-312Arg variant exhibited a shorter TTP during ADT."In the Results section, under "Impact of DHEAS Import on AR Signaling and Cell Growth," SLCO2B1-312Gln and SLCO2B1-312Arg should have been transposed in the third, fourth, and sixth sentences of the first paragraph, as follows: "While both LNCaP and ■ ■
Safety of pregnancy in patients (pts) with history of estrogen receptor positive (ER+) breast cancer (BC): Long-term follow-up analysis from a multicenter study.
Authors: Matteo Lambertini, Niels Kroman, Lieveke Ameye, Octavi Cordoba, Alvaro Pinto, Giovanni Benedetti, Maj-Britt Jensen, Shari I. Gelber, Maria Del Grande, Michail Ignatiadis, Evandro De Azambuja, Marianne Paesmans, Fedro Peccatori, Hatem A. Azim
Journal: Journal of Clinical Oncology (2017)

LBA10066 The full, final text of this abstract will be available at abstracts.asco.org at 7:30 AM (EDT) on Saturday, June 3, 2017, and in the Annual Meeting Proceedings online supplement to the June 20, 2017, issue of the Journal of Clinical Oncology. Onsite at the Meeting, this abstract will be printed in the Saturday edition of ASCO Daily News.
J Thoracic &amp;amp; Cardiovascular Surgery, St. Louis
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medical Historian
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Intra-arterial administration of procaine hydrochloride after arteriography. Potential value in preventing arteriospasm and thrombosis
Authors: W. J. Howland
Journal: JAMA (1967)

In spite of earlier investigator's reports, detailed oscillometric evaluation of peripheral circulation has not produced proof of a significant vasodilating effect of procaine hydrochloride in a series of 55 patients. No blood pressure alteration or other adverse effects occurred. However, prior to the intra-arterial administration of procaine, clinically significant arteriospasm was observed in 38 of 885 arteriographic procedures. After the routine use of procaine, clinical arteriospasm was observed in only two of 1,197 arteriographic procedures, and no arterial or venous thromboses complicated arteriography.
Mandatory HIV testing of youth. A lose-lose proposition
Authors: K. Hein
Journal: JAMA (1991)

Mandatory testing for the human immunodeficiency virus (HIV) in American youth could be a win-win proposition if it benefited young people or society. Neither case is true. Yet mandatory HIV testing policies exist in two of the largest youth employment-training programs in the nation: the Job Corps and all branches of the military. Hundreds of thousands of adolescents under 21 years of age apply to these organizations in hopes of improving their lot in life by gaining new skills while being paid. No one applies because he or she wants an HIV test. A positive HIV test means an end to those hopes. Youths who test HIV positive are not admitted to the military, and the same was true in the Job Corps until 1989. That year, according to Job Corps officials, the policy was changed to reflect the Job Corps' ability to offer
Catfish Stings
Authors: Charles H. Scoggin
Journal: JAMA (1975)

CATFISHES, along with some mollusks, arthropods, stingrays, sharks, puffers, and tropical marine turtles, are recognized as toxic saltwater organisms.<sup>1</sup>While the painful nature of freshwater catfish stings has been known for centuries,<sup>1</sup>the potential of these fish for inflicting a very distressing sting to unwary humans is apparently poorly appreciated by physicians in this country. The following is a description of one such encounter. <h3>Report of a Case</h3> A 24-year-old woman suffered a sting in the thenar pad of her left hand while attempting to clean a 30-cm (12-inch) catfish. She immediately experienced severe pain and paresthesias in the entire extremity followed within minutes by generalized tremulousness and teeth chattering. Because of increasing pain in the affected limb, she sought attention at the Duke University Medical Center emergency room. The patient was in obvious distress, complaining bitterly of pain. Blood pressure was 90/60 mm Hg, pulse rate was 110
Substance use rates among medical students and resident physicians
Authors: J. Westermeyer
Journal: JAMA (1991)

Hughes et al<sup>1</sup>and Baldwin et al<sup>2</sup>have provided a valuable service to the profession and to the community at large through their surveys of substance use among American senior medical students and resident physicians published in this issue ofThe JournalLike corporate leaders, airline pilots, and others whose substance use affects the public's well-being, physicians must be accountable to society. In this time of epidemic substance abuse, our colleagues are not immune to this disorder. Thus, we are obliged to monitor ourselves unless we are willing to pass that responsibility on to others.<sup>3</sup>Since substance abuse among physicians often begins in the training years, yet surfaces to clinical recognition a decade or two later,<sup>4</sup>surveys of medical students and resident physicians can alert us to future substance abuse patterns among practicing physicians. Thus informed ahead of time, we have the opportunity to initiate preventive