tbuckley/cabot-search huggingface dataset:
Organization.
Authors: F. H. Todd
Journal: JAMA (1902)

Wickliffe, Ohio, Oct. 13, 1902. Your article on the chaotic condition of the medical profession as regards its power and influence with the public because of its lack of organization and unity is very timely and to the point. It is to be regretted that the medical profession with all its boasted learning and conceit does not command any power political or civil, compared to organized labor to-day. The profession is not so numerous but that if it were so thoroughly organized as labor, and its individual members more governed by the single-mindedness and good sense of which it boasts, it could wield a tremendous power in politics and could command any reasonable compensation it demanded for services rendered to the state, corporations or individuals. Members of the profession of theology and law far outstrip us today in the respect and power they command in state and civil affairs. If
Caffeine labeling. Council on Scientific Affairs. American Medical Association
Journal: JAMA (1984)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Changes in myocardial blood flow after ischemia-reperfusion: quantitative evaluation by fluorescent microspheres and myocardial contrast echocardiography
Authors: L. Galiuto, K. May-Newman, U. del Balzo, K. Ohmori, V. Bhargava, S.F. Flaim, A.N. DeMaria, S. Iliceto
Journal: Journal of the American College of Cardiology (1998)
The Commonsense Psychiatry of Dr. Adolph Meyer
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Myocardial Protection by Preconditioning of Heart With Losartan, an Angiotensin II Type 1–Receptor Blocker
Authors: Motoaki Sato, Richard M. Engelman, Hajime Otani, Nilanjana Maulik, John A. Rousou, Joseph E. Flack, David W. Deaton, Dipak K. Das
Journal: Circulation (2000)

Background —Ischemic preconditioning (PC) represents a state-of-the-art technique for myocardial preservation. Although certain intracellular mediators have been shown to play a role in PC, the exact nature of the trigger for PC is not known. Our previous study demonstrated that intracellular bradykinin released from the heart during ischemia/reperfusion plays a role in myocardial preservation. This study was undertaken to further examine the mechanism of bradykinin-mediated PC. Methods and Results —Since the bradykinin B 2 receptor is likely to provide cardioprotection by blocking angiotensin II formation, we determined the effects of an angiotensin II type 1 (AT 1 ) receptor blocker, losartan, and a bradykinin B 2 receptor blocker, HOE 140, on myocardial protection. Isolated rat hearts were perfused initially by the Langendorff mode with Krebs-Henseleit buffer (KHB) for 15 minutes in the absence (control) or presence of losartan (4.5 μmol/L) and/or HOE 140 (10 μmol/L). After conversion to the working mode for 10 minutes (baseline), randomly assigned control and experimental hearts were subjected to 30 minutes of normothermic global ischemia followed by 2 hours of reperfusion. Myocardial function, infarct size, cardiomyocyte apoptosis, and amount of bradykinin/angiotensin released from the hearts were measured at baseline and during reperfusion while in the working mode. Significant postischemic ventricular recovery was demonstrated by improved developed pressure and aortic flow and reduced myocardial infarct size and apoptotic cell death with losartan, whereas the reverse was true for HOE 140. The functional recovery and infarct size–lowering ability of losartan were partially blocked and the antiapoptotic function of losartan was completely blocked by HOE 140. Conclusions —The results document that losartan reduced whereas HOE 140 increased myocardial ischemia/reperfusion injury by blocking AT 1 and bradykinin B 2 receptors, respectively, suggesting a role of the bradykinin B 2 receptor in PC. Losartan provided cardioprotection through both bradykinin-dependent and bradykinin-independent mechanisms.
Uterine perforation by intrauterine devices
Authors: M. L. Richardson
Journal: JAMA (1982)

<h3>In Reply.—</h3> In my response to Dr Crumrine, I stated, "The company policy should be developed with physician input and full consideration of [EEOC] regulations and EEOC decisions on similar cases." The employer has full responsibility for the safety and health of the worker in the workplace. Therefore, the company should have a policy on the placement of employees in the workplace. I further stated, "The decision on waiving restrictions for the employee on the application for employment with a definite inguinal hernia and a moderate-sized defect rests with the examining physician who should be guided by company guidelines." I agree that a physician should not permit nonmedical considerations, especially laws that are directed to the employer, to modify his medical judgment; however, the physician should not function in a vacuum, isolated from the rules and regulations of society. I also agree that a physician should maintain medical confidentiality when
Stereoselective Metabolism of Dibenz(a,h)anthracene to trans-Dihydrodiols and Their Activation to Bacterial Mutagens
Authors: Karl L. Platt, Michael Schollmeier, Heinz Frank, Franz Oesch
Journal: Environmental Health Perspectives (1990)

Dibenz(a,h)anthracene (DBA), a carcinogenic, polycyclic aromatic hydrocarbon ubiquitous in the environment, is metabolized by the hepatic microsomal fraction of immature Sprague-Dawley rats pretreated with Aroclor 1254 to 27 ethyl acetate-extractable metabolites. More than half of these metabolites (51%) consisted of trans-1,2-; -3,4-; and -5,6-dihydrodiols including their identified secondary metabolites. The three trans-dihydrodiols (4.9, 15.8, and 0.6% of total metabolic conversion) were highly enriched in their R,R enantiomers (85, 71, and 98%) as determined by high performance liquid chromatography on suitable chiral stationary phases. This is explained on the basis of the stereoselective epoxidation of DBA by cytochrome P-450c (induced by Aroclor 1254) followed by regioselective hydration catalyzed by microsomal epoxide hydrolase. Determination of the bacterial mutagenicity by measuring the reversion rate of histidine-dependent Salmonella typhimurium TA100 to histidine prototrophy revealed marked differences in the mutagenicity of the enantiomers of the trans-dihydrodiols of DBA when activated by the same metabolizing system as used in the metabolism studies. In the case of trans-1,2- and -5,6-dihydrodiol, the S,S enantiomers were converted to more mutagenic metabolites than their corresponding optical antipodes, whereas in the case of trans-3,4-dihydrodiol it was the R,R enantiomer that produced the stronger mutagens. Therefore, both regio- and stereoselectivity of the metabolizing enzymes attribute to the dominant role of trans-3,4-dihydrodiol in the mutagenicity of DBA.
THOMAS DOVER (1662-1742)-RESCUER OF ROBINSON CRUSOE
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diploid cell measles vaccine
Authors: J. Fernandez de Castro
Journal: JAMA (1986)

<h3>To the Editor.—</h3> Dr Albert Sabin and one of us (J.F.D.)<sup>1,2</sup>recently reported seroconversion in infants administered measles vaccine of human diploid cells (HDCs) that contained the Ikić (Edmonston-Zagreb) strain and 1% human albumin, or chick embryo fibroblast (CEF) vaccine that contained the Edmonston-Schwartz strain by cutaneous or aerosol routes. In that study, we used enzyme-linked immunosorbent assay and plaque neutralization tests to demonstrate seroconversion. In this letter we report a further study inwhich antibody was measured using the more standard hemagglutination inhibition. This double-blind study was carried out in children aged 6 to 8 months residing in two poor urban areas of Mexico City between October 1983 and April 1984. <h3>Report of a Case.—</h3> One hundred seventy-two children received HDC vaccine manufactured in Mexico: 117 via aerosol (titer of virus, 10<sup>5.2</sup>50% tissue culture infective dose per milliliter), and 55 by injection (titer of virus, 10
A phase II trial of pemetrexed (P) plus carboplatin (C) in patients (pts) with advanced non-small-cell lung cancer (NSCLC)
Authors: S. Koshy, R. S. Herbst, C. K. Obasaju, F. Fossella, V. Papadimitrakopoulou, K. M. W. Pisters, G. Blumenschein, B. O. Peeples, W. K. Hong, R. G. Zinner
Journal: Journal of Clinical Oncology (2004)

7074 Background: P (Alimta), a multitargeted antifolate, inhibits thymidylate synthase, dihydrofolate reductase and glycinamide ribonucleotide formyl transferase. P and cisplatin are synergistic in preclinical models. Response rates (RR) of 39–45% were noted in Phase II P/cisplatin studies (Shepherd, Cancer, 2001; Manegold, Ann Oncol, 2000) with 1-year survival (1YS) of 50% in chemonaive advanced NSCLC. Substituting C for cisplatin may improve the toxicity profile yet maintain efficacy. The primary objective of this study was determination of the RR of PC in advanced chemonaive NSCLC pts. Methods: Eligibility criteria: zubrod performance status (PS) ≤1, chemonaive stage IIIB/IV. Treatment was P 500mg/m2 IV D1 followed by C AUC=6 IV D 1 Q 3 wks X 6 cycles. All pts received folic acid, vitamin B12 and steroid prophylaxis. Results: All are evaluable for toxicity; 3 pts remain on treatment. Pt characteristics: median age=62 (31–80), 31 male, stage IIIa=1/IIIb=3/IV=46, PS 0=5/1=46. Grade (G) 3/4 hematologic toxicities were neutropenia (34% pts) thrombocytopenia (4%), anemia (10%). 5/50 pts had G3/4 nonhematologic toxicities: G3 nausea/G 4 emesis (1pt), G3 diarrhea (1), G3 DVT (2), G1 sensory neuropathy (7), G1 alopecia (4). Steroid prophylaxis was effective, with no rash ≥ G3. Partial RR was 28% and stable disease was 48%. Median time to progression (TTP) was 4.9 mos (3.1–6.4mos). With a minimum of 10 mos follow-up, estimated median and 1YS are 13.5 mos (10.1–15.6mos) and 55.3% (41.3%–69.3%). Median # courses was 6 (1–15+). Conclusions: PC has promising RR, TTP, median and 1YS. Its q3 wk schedule is convenient and causes minimal nonhematologic and hematologic toxicities. Notably, G3/4 nausea/emesis were rare; alopecia and sensory neuropathy were ≤ G1. This is a highly tolerable regimen with promising efficacy, especially with 92% of pts having stage IV disease. Its activity is comparable to P/cisplatin and may be as effective but better tolerated than standard first-line platinum doublets. Trials focused on how to integrate PC with targeted agents are warranted. Supported by Eli Lilly Oncology, Indianapolis, Indiana. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Eli Lilly Oncology Eli Lilly Oncology Eli Lilly
Pityriasis versicolor
Authors: S. Renati, A. Cukras, M. Bigby
Journal: BMJ (2015)

We report a female infant with the Majewski syndrome, one of a group of conditions characterised by short ribs, polydactyly, dwarfism, and early neonatal death. This syndrome seems to be extremely rare, with only five well documented cases reported and, including this case, nine recorded in all. The Majewski syndrome is considered to be recessively inherited, and this report adds further support to this hypothesis, as the infant was born to consanguineous parents.
Unsuspected human immunodeficiency virus in critically ill emergency patients
Authors: J. L. Baker
Journal: JAMA (1987)

To determine the prevalence of unsuspected human immunodeficiency virus (HIV) infection in critically ill emergency patients, we examined the anonymous serum samples of 203 critically ill or severely injured patients with no history of HIV infection. We found that six (3%) were seropositive for HIV antibody by both enzyme-linked immunoassay and Western blot analysis. All seropositives were trauma victims between the ages of 25 and 34 years, representing 16% of the trauma patients in that age group (n = 37). All seropositives were actively bleeding, and all required multiple invasive procedures. History of intravenous drug abuse was not discriminating in identifying potential seropositives. We conclude that infection-control precautions are indicated for both emergency department personnel and prehospital care providers (such as paramedics, police officers, and fire fighters) when caring for bleeding patients, whether or not previous suspicion of HIV infection exists. (<i>JAMA</i>1987;257:2609-2611)
THE AMBULANCE IN AMERICAN CITIES.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Biological Implications of Eradication and Control
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Adventitial remodeling after angioplasty is associated with expression of tenascin mRNA by adventitial myofibroblasts Kurt Wallner, Behrooz G. Sharifi, Prediman K. Shah, Sumiko Noguchi, Hector DeLeon, Josiah N. Wilcox. Cedars-Sinai Med. Ctr., Los Angeles, CA, Emory University, Atlanta, GA
Journal: Journal of the American College of Cardiology (2001)
Bronchial hyperresponsiveness and adult onset wheeze: the influence of atopy
Authors: C Bodner, D Godden, S Ross, J Little, JG Douglas, J Legge, A Seaton, J Friend
Journal: European Respiratory Journal (1999)

The commonly held belief that adult onset wheezing illness is primarily nonatopic in nature suggests that the role of atopy in the pathophysiology of bronchial hyperresponsiveness (BHR) in adult onset wheeze may be minimal. This study examined risk factors for BHR (BHR: provocative dose causing a 20% fall in forced expiratory volume in one second PD20 &lt; or =16.38 micromol methacholine) among 82 subjects with adult onset wheeze and among 191 subjects who had never wheezed. Subjects were identified from a cohort of subjects aged 39-45 yrs who were known to have had no childhood wheeze and who were involved in a 30 yr follow-up survey. Risk factors for BHR were examined among all subjects with BHR and among subjects with BHR stratified according to whether or not they had ever wheezed. The prevalence of BHR was 40% (33/82) among the subjects with adult onset wheeze and 11% (21/191) among the subjects who had never wheezed. Lower baseline lung function (odds ratio (OR) = 0.94; 95% confidence interval (CI) = 0.92-0.97 per unit forced expiratory volume (FEV1)% predicted) and atopy (OR = 7.23; CI = 2.53-20.64 for all three measures of atopic compared to nonatopic) were associated with BHR, while smoking and family history showed no statistically significant relation to BHR. This pattern was also apparent in analyses stratified by symptom status. A family history of atopy increased the risk that BHR was accompanied by wheezing symptoms (OR = 4.75; CI = 1.53-14.72 for more than one affected relative compared to no affected relatives). These findings suggest that atopy is associated with bronchial hyperresponsiveness in adults known to have had no childhood wheeze. A familial factor reflecting genetic influences and/or shared environmental factors may influence whether bronchial hyperresponsiveness is associated with symptoms.
308. Valproic Acid, a Histone Deacetylase Inhibitor, Is an Antagonist for Oncolytic Adenoviral Gene Therapy
Authors: Naser Uddin Hoti, Shawn E. Lupold, Wasim Chowdhury, Jer- Tsong Hsieh, Ronald Rodriguez
Journal: Molecular Therapy (2006)

Oncolytic adenoviruses preferentially replicate and lyse tumor cells. However, their application to cancer gene therapy has been complicated by the low levels of Coxsackie and Adenovirus Receptor (CAR) expressed in many solid tumors. Histone Deacetylase Inhibitors (HDACI) significantly up-regulate CAR expression in tumor cells and have additional anti-neoplastic activities. Therefore, there is a clear rational for the combination of HDACIs and oncolytic adenoviral gene therapy. We present evidence that HDACI treatement significantly inhibits adenoviral replication, viral burst, and tumor cell kill. Valproic Acid (VPA), a well established HDACI, inhibits replication late in the viral lifecycle. We hypothesized that VPA induction of the cell cycle regulating protein, p21WAF1/CIP1, may be partly responsible for this activity. We demonstrate that p21WAF1/CIP1 expression alone limits viral replication and decreases viral titers in different cancer cell models. Surprisingly, we also demonstrate that VPA and replicating adenovirus mutually inhibit each other's ability to kill cells, independent of p21WAF1/CIP1 expression. These results not only identify the importance of p21WAF1/CIP1 in the biology of adenoviral replication, but also suggest that VPA (HDACI) should not be combined with oncolytic adenoviral gene therapy.
Deaths and Hospitalizations From Chronic Liver Disease and Cirrhosis—United States, 1980-1989
Journal: JAMA (1993)

In 1989, chronic liver disease, including cirrhosis, was the ninth most frequent cause of death in the United States (1). Periodic analysis of trends and factors related to preventable death and hospitalization for chronic liver disease may be used to target prevention and control programs. This report examines national trends in death and hospitalization rates and state-specific death rates for chronic liver disease using data from CDC's National Center for Health Statistics' multiple-cause-of-death file and the National Hospital Discharge Survey (NHDS).