tbuckley/cabot-search huggingface dataset:
A phase II, single-arm clinical trial involving an alternative cancer treatment psorinum therapy in patients with advanced esophageal carcinoma.
Authors: A. Chatterjee, J. Biswas, S. Bhattacharya, A. K. Chatterjee, A. Chakraborty, R. S. Bhakta
Journal: Journal of Clinical Oncology (2011)

e13044 Background: We prospectively studied the clinical efficacy of an alternative cancer treatment “psorinum therapy” in patients with advanced esophageal carcinoma (ECA). Methods: Our study was phase- II, open level, single arm and single stage. Participants’ eligibility criteria included (1) histopathology confirmation of ECA; (2) inoperable tumor (3) no prior conventional cancer treatments (4) Karnofsky performance status between 40- 70%. The primary outcome measures of the study were (1) to assess the radiological tumor response rate (using CT scanning procedure and following the RECIST criteria); (2) to assess how many participants survived at least 1 yr, 2 yrs, 3 yrs, 4 yrs, and finally, after 5 yrs of the study. The secondary outcome measure was to assess the side effects of the investigational anti- cancer drug (psorinum) if any. The drug psorinum (an alcoholic extract of scabies, slough and pus cells) was administered orally at 0.02ml/ Kg body weight / day as a single dose in empty stomach and ongoing for complete course duration of 2 years to all the participants along with allopathic and homeopathic supportive cares. Results: 65 participants included in the final analysis at the end of the study. According to the RECIST criteria, complete tumor response occurred in 11 (16.92%) cases and partial response occurred in 20 (30.77%) cases. 44 (67.69%) of them survived at least 1 yr, 32 (49.23%) survived at least 2 yrs, 24 (36.92%) survived at least 3 years, 21 (32.31%) survived at least 4 years and 17 (26.15%) of them survived at least 5 years. These participants did not receive conventional or any other investigational cancer treatments. Conclusions: The results of the study show clinical efficacy of psorinum therapy in treating patients with advanced esophageal carcinoma. The investigational drug psorinum is non- toxic. Randomized controlled clinical trial should be conducted for further investigation of this alternative cancer treatment in treating esophageal carcinoma.
Correction
Journal: BMJ (1947)

ANY QUESTIONS ? BIUTISHVarious vitamin deficiencies and disturbances in the alimentary tract have also been blamed.It is possible that different mechanisms operate in different cases.Treatment is unsatis- factory.Protein-sensitivity tests should be carried out and any focus of sepsis in the mouth eradicated.Large doses of vita- min C might be tried.Chorionic gonadotrophin (500 i.u.intramuscularly twice weekly) appears to help in some cases, but may have to be continued indefinitely.See also replies to questions in the Journial for Dec. 25, 1943 (p. 839),and June 15, 1946 (p. 940).Green Teeth Q.-I have a patient aged 2 years with " green teet/h."Has the Rh factor any bearing on thlis disease ?A.-The presence of true green teeth is a rare condition usually following icterus gravis, and has been noted in the permanent teeth of patients who have recovered from that disease in infancy.The Rh factor is, of course, connected with this disorder.The more common appellation of green teeth is given to teeth showing the characteristic green stain of chromogenic bacteria.This is often seen on the anterior teeth in children, and can usually be removed with mild abrasives. Generalized Pruritus
Elements of Surgical Pathology.
Authors: None W. A.
Journal: JAMA (1884)

This is one of the series of small volumes for elementary study issued under the title of Manuals for Students of Medicine. It is similar in form to the volume on Applied Anatomy mentioned recently (p. 734) in these columns. These little books fill a gap in medical literature between the bulky systematic treatises on the one hand, and the worthless and trashy<i>vade mecums</i>and compends on the other. <i>Cui bono?</i>asks a critic in a recent number of the<i>Physician and Surgeon</i>, since these books contain nothing which cannot be found in the standard authorities. The answer is simple. Medical college training, like all other instruction, must be made more systematic and special, and around it must grow up a specialized literature adapted to graded teaching. The present volume, beside being a most excellent introduction to any amount of pathological research, is in itself sufficiently complete to prepare
High prevalence of recent cocaine use and the unreliability of patient self-report in an inner-city walk-in clinic
Authors: S. E. McNagny
Journal: JAMA (1992)

<h3>Objective.</h3> —To determine the prevalence of recent cocaine use and the reliability of patient self-reported cocaine use. <h3>Design.</h3> —A survey with blinded comparison to a criterion standard. <h3>Setting.</h3> —Walk-in clinic of a large public hospital in metropolitan Atlanta, Ga. <h3>Participants.</h3> —Male patients, aged 18 to 39 years, presenting to the triage desk for immediate care during weekdays. Of the 415 eligible men who agreed to participate (acceptance rate, 82%), the average age was 29.5 years, 91.6% were black, and 89% were uninsured. <h3>Intervention.</h3> —None. <h3>Main Outcome Measures.</h3> —Comparison of self-reported illicit drug use with results from urinary immunoassays for benzoylecgonine, a major cocaine metabolite. Determination of which drug history questions produce the most accurate responses using anonymous urine testing as the criterion standard. <h3>Results.</h3> —Thirty-nine percent of patients tested positive for the presence of benzoylecgonine and were statistically more likely to be older, black, and have a prior history of sexually transmitted disease (<i>P</i>&lt;.01). Seventy-two percent of men with positive urinary assays denied illicit drug use in the 3 days prior to sampling. When queried with several formats, subjects with positive urine assays were more likely to admit to "any illegal drug" use (87.5%) than to the more specific "any form of cocaine" use (60.6%) within the prior year (<i>P</i>&lt;.0001). <h3>Conclusions.</h3> —These results underscore the magnitude of cocaine abuse among black, inner-city men. Patient self-report of illicit drug use is highly inaccurate. Accuracy of self-report may be increased by asking less specific questions. (<i>JAMA</i>. 1992;267;1106-1108)
Union Médicale du Canada, Montreal
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Consensus Development Conference on the Management of Localized Prostate Cancers
Journal: JNCI Journal of the National Cancer Institute (1990)

Journal Article Consensus Development Conference on the Management of Localized Prostate Cancers Get access JNCI: Journal of the National Cancer Institute, Volume 82, Issue 16, 15 August 1990, Page 1369, https://doi.org/10.1093/jnci/82.16.1369 Published: 15 August 1990
Correction: <i>The putative tumour suppressor microRNA-124 modulates hepatocellular carcinoma cell aggressiveness by repressing ROCK2 and EZH2</i>
Journal: Gut (2021)

The representative image of siEZH2 cells in Figure 4A, and the representative images of miR-124, miR-124-ROCK2 and miR-control cells in Figure S5 were incorrect.The correct Figure 6 and Figure S5 are shown below.The figure legend remains the same.
Patient Decisions to Undergo Surgery for Early-Stage Lung Cancer—Reply
Authors: Samuel Cykert
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The effect of marital status on stage, treatment, and survival of cancer patients
Authors: J. S. Goodwin
Journal: JAMA (1987)

The effects of marital status on the diagnosis, treatment, and survival of patients with cancer were examined in population-based data on 27779 cancer cases. Unmarried persons with cancer had decreased overall survival (relative hazard, 1.23; 95% confidence limits, 1.19 to 1.28). We identified three complementary explanations for the poorer survival of the unmarried persons. First, unmarried persons were more likely to be diagnosed at a regional or distant stage (odds ratio, 1.19; 95% confidence limits, 1.12 to 1.25). After adjustment for stage, unmarried persons were more likely to be untreated for cancer (odds ratio, 1.43; 95% confidence limits, 1.31 to 1.55). Finally, after adjustment for stage and treatment, unmarried persons still had poorer survival. Previous studies have demonstrated that unmarried persons have decreased overall mortality. For cancer, our results suggest that the favorable consequence of being married on overall survival is secondary to the beneficial effects at several steps in the diagnosis, choice of treatment, and response to treatment. (<i>JAMA</i>1987;258:3125-3130)
Hispanic HANES takes long look an latino health
Authors: C. Marwick
Journal: JAMA (1991)

A MUCH clearer picture of the health of Americans of Spanish origin is becoming available as the analyses of the data gathered from 1982 through 1984 by the Hispanic Health and Nutrition Examination Survey (HANES) are published. This effort, the first special population health survey ever conducted by the National Center for Health Statistics, studied Cuban Americans, Mexican Americans, and Puerto Ricans residing in the continental United States. "The Hispanic population is the second largest minority group in the United States and the fastest growing. Yet little has been known about their general health and nutritional status," says Robert S. Murphy, who is Director of the Division of Health Examination Statistics at the National Center for Health Statistics (<i>Am J Public Health</i>. 1990;80:1429). The Hispanic survey covers some major health issues in the group that is expected soon to be the largest minority group of Americans, says Murphy. He cites
2020 American Heart Association and American College of Cardiology Consensus Conference on Professionalism and Ethics: A Consensus Conference Report
Authors: Ivor J. Benjamin, C. Michael Valentine, William J. Oetgen, Katherine A. Sheehan, Ralph G. Brindis, William H. Roach, Robert A. Harrington, Glenn N. Levine, Rita F. Redberg, Bernadette M. Broccolo, Adrian F. Hernandez, Pamela S. Douglas, Ileana L. Piña, Emelia J. Benjamin, Megan J. Coylewright, Jorge F. Saucedo, Keith C. Ferdinand, Sharonne N. Hayes, Athena Poppas, Karen L. Furie, Laxmi S. Mehta, John P. Erwin, Jennifer H. Mieres, Daniel J. Murphy, Gaby Weissman, Colin P. West, Willie E. Lawrence, Frederick A. Masoudi, Camara P. Jones, Daniel D. Matlock, Jennifer E. Miller, John A. Spertus, Lynn Todman, Cathleen Biga, Richard A. Chazal, Mark A. Creager, Edward T. Fry, Michael J. Mack, Clyde W. Yancy, Richard E. Anderson
Journal: Journal of the American College of Cardiology (2021)
Transmission of Pertussis From Adult to Infant—Michigan, 1993
Journal: JAMA (1995)

During 1993, a total of 6586 pertussis cases was reported in the United States, including 675 (10%) cases among persons aged > 19 years. However, the total number of cases probably was substantially higher because only an estimated 10% of all pertussis cases are reported (1); underreporting is greater among adults, who often have only a mild cough. This report summarizes the investigation of two cases of pertussis in which transmission occurred from an adult resident of Massachusetts who was visiting the residence of an infant in Michigan.
What Are the Vitamins?
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PARACHUTE INJURIES
Authors: WILLIAM J. TOBIN
Journal: JAMA (1941)

This paper is a preliminary survey of the injuries sustained during the first year of parachute jumping. A detailed description of the technic of parachute jumping has not been attempted; however, those phases of jumping that have resulted in injuries will be discussed. We feel that this presentation will clarify the popular belief that parachute injuries are alarmingly high. All of the available foreign literature was reviewed. An article by René de Gaulejac<sup>1</sup>covered the subject best. De Gaulejac, reviewing the injuries in 1939. classified them into four major groups: (1) injuries which resulted in death, (2) abdominothoracic injuries with or without nervous or vascular complications, (3) various organic lesions with extremely diverse localization and origin, and (4) the more or less complicated injuries of the lower extremities. The lesions of the first group corresponded to the first phase of the jump, where accidents occurred either by entanglement with
Journal Amer Geriatrics Society, Baltimore
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction
Journal: BMJ (1947)

rule but to take all the facts into account.I know of no reported case in which the Court has decided merely on the alleged length of pregnancy that the child was illegitimate.Griffiness in the Eye Q.-What is the cauise of the com1zmon0 ocular symtlptotn of grittiness in the eye ?A chara'cteristic feature of this conditioz is that it is worse on waking.A.-There is no clear answer to this question.There are probably a number of different causes-that can produce the sensation of grittiness in the eye.A not uncommon cause is the presence of small calcareous granules in the conjunctiva.These are fairly easily levered out by means of the sharp point of a cataract knife.The characteristic feature mentioned-that it is worse on waking-rather suggests that the symptom may arise from an excessive concentration of the solid contents of tears.This raises the complicated issue of minor metabolic disturbances.As an empirical measure your correspondent may find it worth while trying the effect of diuretics.
The Worldwide Smoking Epidemic
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nordisk Medicin, Stockholm
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Molecular Pharmacologic Approaches To The Treatment Of Aids
Authors: P. Sarin
Journal: The Annual Review of Pharmacology and Toxicology (1988)

Heme oxygenases (HO) catabolize free heme, that is, iron (Fe) protoporphyrin (IX), into equimolar amounts of Fe2+, carbon monoxide (CO), and biliverdin. The stress-responsive HO-1 isoenzyme affords protection against programmed cell death. The mechanism ...Read More
Oral Pharmacologic Treatment of Type 2 Diabetes Mellitus: A Clinical Practice Guideline Update From the American College of Physicians
Authors: Amir Qaseem, Michael J. Barry, Linda L. Humphrey, Mary Ann Forciea
Journal: Annals of Internal Medicine (2017)

Description: The American College of Physicians (ACP) developed this guideline to present the evidence and provide clinical recommendations on oral pharmacologic treatment of type 2 diabetes in adults. This guideline serves as an update to the 2012 ACP guideline on the same topic. This guideline is endorsed by the American Academy of Family Physicians. Methods: This guideline is based on a systematic review of randomized, controlled trials and observational studies published through December 2015 on the comparative effectiveness of oral medications for type 2 diabetes. Evaluated interventions included metformin, thiazolidinediones, sulfonylureas, dipeptidyl peptidase-4 (DPP-4) inhibitors, and sodium–glucose cotransporter-2 (SGLT-2) inhibitors. Study quality was assessed, data were extracted, and results were summarized qualitatively on the basis of the totality of evidence identified by using several databases. Evaluated outcomes included intermediate outcomes of hemoglobin A1c, weight, systolic blood pressure, and heart rate; all-cause mortality; cardiovascular and cerebrovascular morbidity and mortality; retinopathy, nephropathy, and neuropathy; and harms. This guideline grades the recommendations by using the GRADE (Grading of Recommendations Assessment, Development and Evaluation) system. Target Audience and Patient Population: The target audience for this guideline includes all clinicians, and the target patient population includes adults with type 2 diabetes. Recommendation 1: ACP recommends that clinicians prescribe metformin to patients with type 2 diabetes when pharmacologic therapy is needed to improve glycemic control. (Grade: strong recommendation; moderate-quality evidence) Recommendation 2: ACP recommends that clinicians consider adding either a sulfonylurea, a thiazolidinedione, an SGLT-2 inhibitor, or a DPP-4 inhibitor to metformin to improve glycemic control when a second oral therapy is considered. (Grade: weak recommendation; moderate-quality evidence.) ACP recommends that clinicians and patients select among medications after discussing benefits, adverse effects, and costs.