tbuckley/cabot-search huggingface dataset:
Pregnancy alters glucose-6-phosphate dehydrogenase trafficking, cell metabolism, and oxidant release of maternal neutrophils
Authors: Andrei L. Kindzelskii, Ji-Biao Huang, Tinnakorn Chaiworapongsa, Ryan M. Fahmy, Yeon Mee Kim, Roberto Romero, Howard R. Petty
Journal: Journal of Clinical Investigation (2002)

Pregnancy is associated with changes in host susceptibility to infections and inflammatory disease. We hypothesize that metabolic enzyme trafficking affects maternal neutrophil activation. Specifically, immunofluorescence microscopy has shown that glucose-6-phosphate dehydrogenase (G-6-PDase), the rate-controlling step of the hexose monophosphate shunt (HMS), is located near the cell periphery in control neutrophils but is found near the microtubule-organizing centers in cells from pregnant women. Cytochemical studies confirmed that the distribution of the G-6-PDase antigen is coincident with functional G-6-PDase activity. Metabolic oscillations within activated pregnancy neutrophils are higher in amplitude, though lower in frequency, than activated control neutrophils, suggesting limited HMS activity. Analysis of radioisotope-labeled carbon flux from glucose to CO2 indicates that the HMS is intact in leukocytes from pregnant women, but its level is not enhanced by cell stimulation. Using extracellular fluorescent markers, activated pregnancy neutrophils were found to release reactive oxygen metabolites (ROMs) at a lower rate than activated control neutrophils. However, basal levels of ROM production in polarized pregnancy neutrophils were greater than in control neutrophils. Microtubule-disrupting agents reversed the observed changes in G-6-PDase trafficking, metabolic oscillations, and ROM production by maternal neutrophils. G-6-PDase trafficking appears to be one mechanism regulating ROM production by maternal neutrophils.
Can the Practice of Retainer Medicine Improve Primary Care?
Authors: Josh J. Umbehr
Journal: Annals of Internal Medicine (2012)

Letters6 March 2012Can the Practice of Retainer Medicine Improve Primary Care?Josh J. Umbehr, MDJosh J. Umbehr, MDFrom AtlasMD Concierge Family Practice, Wichita, KS 67206.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-156-5-201203060-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Although I think that there is plenty of room for debate on many of the points mentioned in the article by Huddle and Centor (1), I'd like to focus on a different point: Not all retainer models are the same. I think we are making a basic mistake of assuming that all “insurance-free” models are designed for the upper crust.My model is not. We charge $10 to $100 a month per patient on the basis of age (all preexisting conditions welcome) for unlimited home, work, office, or technology visits with no copay. We offer steep discounts ...Reference1. Huddle TS, Centor RM. Retainer medicine: an ethically legitimate form of practice that can improve primary care. Ann Intern Med. 2011;155:633-5. [PMID: 22041952] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From AtlasMD Concierge Family Practice, Wichita, KS 67206.Disclosures: Dr. Umbehr is the owner, operator, and chief executive officer of a concierge medical practice. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoRetainer Medicine: An Ethically Legitimate Form of Practice That Can Improve Primary Care Thomas S. Huddle and Robert M. Centor Can the Practice of Retainer Medicine Improve Primary Care? Douglas M. Van Zoeren Can the Practice of Retainer Medicine Improve Primary Care? James Webster Can the Practice of Retainer Medicine Improve Primary Care? Martin T. Donohoe Can the Practice of Retainer Medicine Improve Primary Care? Thomas S. Huddle and Robert M. Centor Can the Practice of Retainer Medicine Improve Primary Care? Marcy Zwelling Metrics 6 March 2012Volume 156, Issue 5Page: 399KeywordsConflicts of interestPatientsQuality of lifeResearch laboratories ePublished: 6 March 2012 Issue Published: 6 March 2012 CopyrightCopyright © 2012 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
DDRE-03. INTERNATIONAL PRECLINICAL DRUG DISCOVERY AND BIOMARKER PROGRAM INFORMING AN ADOPTIVE COMBINATORIAL TRIAL FOR DIFFUSE MIDLINE GLIOMAS
Authors: Justyna Przystal, Sridevi Yadavilli, Christina Coleman Abadi, Viveka Nand Yadav, Sandra Laternser, Chiara Cianciolo Cosentino, Sebastian Waszak, Rodrigo Cartaxo, Matt Biery, Carrie Myers, Samantha Jayasekara, James Olson, Mariella Filbin, Nicholas Vitanza, Jason Cain, Carl Koschmann, Sabine Mueller, Javad Nazarian
Journal: Neuro-Oncology (2020)

Abstract INTRODUCTION DMG-ACT (DMG- multi-arm Adaptive and Combinatorial Trial) aims to implement a highly innovative clinical trial design of combinatorial arms for patients with diffuse midline gliomas (DMGs) at all disease stages that is adaptive to pre-clinical data generated in ten collaborating institutions. Novel drug and drug combination were tested, predictive biomarkers were identified and incorporated in clinical trial design. METHODS In vitro (n=15) and in vivo (n=8) models of DMGs across ten institutions were used to assess single and combination treatments with ONC201, ONC206, marizomib, panobinostat, 5-Azacytidine, Val-083, GDC0084 and TAK228. In vivo drug toxicity screenings were conducted using larval zebrafish model and murine PDX models. Predictive biomarkers for ONC201 and ONC206 were identified using meta-analysis, and extensive molecular assays including CRISPR, RNAseq, FACS, and IHC. RESULTS Inhibitory concentrations (IC50) were established and validated multiple preclinical models. ONC201 and ONC206, ONC201 and TAK228, ONC201 and GDC0084 showed synergism. In vivo survival assays showed increased survival for: ONC201 (p=0.01), ONC206 (p=0.01), ONC201+ONC206 (p=0.02), and ONC201+panobinostat (p=0.01). Marizomib showed toxicity in murine/zebrafish PDXs models. Murine pharmacokinetic analysis showed peak brain levels of ONC201 and ONC206 above pre-clinical IC50. Molecular testing and analyses of existing drug screen across 537 cancer cell lines validated mitochondrial protease ClpP and ATF4 as ONC201/6 targets. Predictive biomarkers of response to drug were identified. CONCLUSION Thorough preclinical testing in a multi-site laboratory setting is feasible and identified ONC201 in combination with ONC206, TAK228 and GDC0084 as promising therapeutics for DMGs.
This Week in <emph>JAMA</emph>
Journal: JAMA (2008)

A Piece of My Mind"Patients are no longer passive and adoring, and our relationship is no longer hierarchical and paternalistic."From "Who's Afraid of the Empowered Patient?" SEE PAGE 1393 Medical News & PerspectivesA new report highlights the substantial barriers that many primary care physicians face in being paid for the mental health services they provide to patients, despite the demonstrated benefits of such front-line care.
Group therapy
Authors: M. F. Weiner
Journal: JAMA (1975)

IT IS tempting to begin by stating dramatically: there is no such thing as "group psychotherapy." The only common denominator between therapeutic groups is that the therapist deals with more than one patient during the therapeutic session. The worth of a group method depends on the therapist, the method itself, and the specific composition of a group at the time it begins or when a new member enters. Even more important, it depends on the interaction between these variables and the personality of the individual patient. <h3>Types of Groups</h3> There are three basic types of therapy groups. The<i>guidance</i>or didactic group is essentially a class in which the leader teaches patients to deal with conscious attitudes and concrete reality problems. This approach is frequently used to help people with "real" problems they have in common, such as delinquent or retarded children, or a psychiatrically hospitalized spouse. The<i>counseling</i>or
Preferences for CPR and Life-Sustaining Treatment Among Nursing Home Residents
Authors: Mark Hilberman
Journal: JAMA (1996)

<h3>To the Editor.</h3> —The article by Ms O'Brien and colleagues<sup>1</sup>on nursing home patient preferences regarding cardiopulmonary resuscitation (CPR) perplexed me. Not only is the baseline consent inadequate, but the study avoids the critical issues: When is CPR good medical care and therefore indicated? When not? When should it be offered? First, success rates for out-of-hospital resuscitation are dismal, except in exceptional circumstances. Murphy et al<sup>2</sup>reported that of 244 elderly patients resuscitated out of hospital, including 40 nursing home residents, there were only 2 survivors and none when the arrest was not witnessed. Of these 2 patients, 1 did not have a cardiac arrest and 1 had a cardiac arrest after arrival in the emergency department, but before being evaluated. A study from Seattle, Wash,<sup>3</sup>reported a 3% survival to hospital discharge for cardiac arrest among nursing home residents compared with a 36% survival to discharge.
A New Agent for the Control of Tinea Versicolor
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nosocomial Infection and Pseudoinfection From Contaminated Endoscopes and Bronchoscopes—Wisconsin and Missouri
Journal: JAMA (1991)

Flexible fiber-optic endoscopes are widely used in the United States for diagnostic and therapeutic procedures. Between uses, endoscopes should be cleaned and disinfected either manually or by using automated machines. However, outbreaks have occurred among patients exposed to contaminated endoscopes or to inadequately disinfected bronchoscopes (1-4). This report summarizes one outbreak of nosocomially acquired infection (Wisconsin) and one of pseudoinfection (Missouri) linked to endoscopes contaminated during cleaning and disinfection by automated reprocessing machines.
Pulse THE MEDICAL STUDENT SUPPLEMENT OF JAMA
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE SURGICAL ASPECTS OF MAJOR NEURALGIA OF THE TRIGEMINAL NERVE.A REPORT OF TWENTY CASES OF OPERATION ON THE GASSERIAN GANGLION, WITH ANATOMIC AND PHYSIOLOGIC NOTES ON THE CONSEQUENCES OF ITS REMOVAL.
Authors: HARVEY CUSHING
Journal: JAMA (1905)

<h3>Case 16.</h3> —Mrs. R., aged 55, was referred to me by Dr. Baker of Elmira, N. Y., through Dr. Osler. <h3>History.</h3> —She had suffered for fifteen years with a neuralgia which originated in the supraorbital territory. It had become acutely aggravated a few years before her ganglion operation after an exposure to a cold wind. She had taken opiates in large doses during this entire period and, indeed, had been addicted to the habit before the onset of her neuralgia. For the last year the pain had been extreme and almost continuous. A constant attendant was necessary, day and night. All inhibition was lost and she invariably screamed aloud during her paroxysms. She was more or less narcotized most of the time and seemingly was maniacal. The teeth had all been extracted at one sitting two years before. No peripheral neurectomies had been undertaken. The entire territory of the fifth nerve
Molecular analysis of allergenic proteins in bovine dander
Authors: J. Rautiainen, J. Pentikäinen, M. Rytkönen, A. Linnala-Kankkunen, J. Pelkonen, T. Virtanen, R. Mäntyjärvi
Journal: Allergy (1996)

An analytic procedure was established to characterize bovine dander proteins with allergenic properties. The proteins from dander extract were separated by size-exclusion gel filtration, and the fractions were studied with SDS-PAGE followed by immunoblotting. An 11-kDa allergen was found in the same gel filtration fractions as 20- and 22-kDa allergens, and this suggests that the 11-kDa allergen is a dimer in its native form. Our method also detected two separate 22-kDa allergens. The primary structure of the major bovine dander allergen (BDA20) was also studied. A protein sequencer was used to determine the amino acid sequences of enzymatically cleaved peptides. The homology searches revealed that BDA20 is not a previously known bovine protein.
Intestinal bypass surgery for morbid obesity. Long-term results
Authors: L. T. DeWind
Journal: JAMA (1976)

Since 1962, jejunoileal bypass has been performed on 59 male and 171 female subjects, aged 18 to 55 years; these patients were followed clinically. Postoperative weight loss at two years averaged 37% in men and 35% in women. Hypokalemia (23%), hypocalcemia (22%), hypoalbuminemia (9%), metabolic acidosis (14%), elevated liver enzyme values (41%), and hyperbilirubinemia (6%), were the most commonly encountered blood chemical alterations. Complications were arthritis syndrome (men, 8%; women, 19%), urinary calculi (men, 24%; women, 10%), cholelithiasis (men, 10%; women, 9%), liver impairment (men, 2%; women, 6%), and major emotional upset (men, 8%; women, 9%). Forty-nine percent of the men and 51% of the women required rehospitalization for management of complications, surgery for hernia, anorectal disorders, nutritional support, and metabolic study. There were 19 bypass-related deaths (8%), including 10 due to liver failure. (<i>JAMA</i>236:2298-2301, 1976)
THE ABSORPTION OF VITAMIN A
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction: Macronutrients
Authors: DEBORAH KATZ
Journal: Annals of Internal Medicine (1983)

Letters and Corrections1 September 1983Correction: MacronutrientsDEBORAH KATZDEBORAH KATZAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-99-3-417 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: A quick perusal of the table of contents of your supplement on nutrition and blood pressure control (1) revealed a glaring mistake that is not a typographical error (see also page 828, same issue).One of the first concepts taught in basic nutrition courses is the difference between macronutrients and micronutrients. Dietary fat, dietary protein, carbohydrates and alcohol are all macronutrients, not micronutrients as you so indicated....Reference1. MCCARRONKOTCHEN DT, eds. Nutrition and blood pressure control: current status of dietary factors and hypertension. Ann Intern Med. 1983;98(5 Pt. 2):697-890. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Box 50, VRC 50; FPO San Francisco, CA 96654 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySome Congenital Immunodeficiencies and Their Dermatological Manifestations 1 September 1983Volume 99, Issue 3Page: 417-417KeywordsAlcoholsBlood pressureCarbohydratesFatsMicronutrientsNutrientsNutritionProteins Issue Published: 1 September 1983 PDF downloadLoading ...
Plastic surgery
Authors: E. G. Zook
Journal: JAMA (1994)

A more complete understanding of the nature of wound healing is bringing change and great optimism to the specialty of plastic surgery. Efforts to gain greater control of the body's reparative process continue. Potential clinical applications for growth factors—most notably platelet-derived growth factor (PDGF) and transforming growth factor β (TGF-β)—include accelerating surgical incision healing, managing decubiti and other nonhealing wounds, and inhibiting scar formation. Animal studies and early clinical trials have shown that growth factors can be powerful agents in manipulating wound repair. In a preliminary safety trial that measured the effects of topical PDGF on decubiti, accelerated wound healing was noted in five of the 23 patients who received the growth factor.<sup>1</sup>Healing was accelerated by an estimated 10 days in the treatment group. Similar encouraging results were seen in a multicenter, prospective, randomized trial that involved elderly nursing home residents. Although no improvement was demonstrated in the
Better Drug Assays, Better Delivery Head Agenda
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Residents Honored for Community Service
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal