tbuckley/cabot-search huggingface dataset:
Carcinoembryonic antigen and blood group-related carbohydrate antigens in glycoproteins in human bile in hepatolithiasi
Authors: M Sasaki
Journal: Hepatology (1996)

We investigated whether carbohydrate antigens on biliary glycoproteins and carcinoembryonic antigen (CEA) are related to hepatolithiasis. CEA, ABO, and Lewis blood group-related antigens, as well as sialyl-Tn antigen in hepatic bile, were analyzed by Western blotting in samples from 12 patients with hepatolithiasis and 37 with other biliary diseases (choledocholithiasis, 13; cholecystolithiasis, 5; acute cholecystitis, 2; cholangiocarcinoma, 5; common bile duct carcinoma, 4; pancreatic carcinoma, 6; and metastatic carcinoma of liver, 2). CEA was positive on mucinous glycoprotein in six patients (50%) with hepatolithiasis and one case (17%) with pancreatic carcinoma. CEA was also positive on a glycoprotein of approximately 200 kd in eight patients (67%) with hepatolithiasis and two (33%) with pancreatic carcinoma. Lewis X was detected on the mucinous glycoprotein in almost all samples, as well as on glycoproteins of approximately 180 kd in all hepatolithiasis samples and approximately half of those from patients with other diseases. Sialyl-Tn antigen was detected on mucinous glycoprotein in four (80%) with cholangiocarcinoma, two (50%) with common bile duct carcinoma, and all pancreatic carcinoma samples. Mucinous glycoprotein and glycoproteins containing CEA and Lewis X antigens are enriched in hepatic bile of hepatolithiasis, and they may be closely related to the formation of intrahepatic calculi. Sialyl-Tn antigen in biliary mucinous glycoprotein will be a good marker of biliary and pancreatic carcinoma, and probably for cholangiocarcinoma complicated with hepatolithiasis.
Paraneoplastic pemphigus with autoantibody deposition in bronchial epithelium after autologous bone marrow transplantation
Authors: S. H. Fullerton
Journal: JAMA (1992)

Paraneoplastic pemphigus is a newly described syndrome in which patients have a severe mucocutaneous eruption with clinical features reminiscent of both erythema multiforme major (Stevens-Johnson syndrome) and pemphigus vulgaris, in association with non-Hodgkin's lymphomas and other malignant neoplasms. These patients have autoantibodies that bind to a characteristic set of epidermal proteins: desmoplakin I and desmoplakin II (molecular weight equals 250 kd and 210 kd, respectively), both major cytoskeletal structural proteins associated with desmosome cellular junctions within all epithelia, the bullous pemphigoid antigen, a 230 kd protein associated with hemidesmosomes, and a 190 000-d protein that has not been characterized. In this report, we describe a patient with paraneoplastic pemphigus who had (1) non-Hodgkin's lymphoma in apparent complete remission following autologous bone marrow transplantation, (2) very tense blisters reminiscent of bullous pemphigoid, (3) a unique pattern of immune deposits within the skin, and (4) IgG deposits within the epithelium of the pulmonary bronchi associated with respiratory compromise. (<i>JAMA</i>. 1992;267:1500-1502)
Selected Abstracts
Journal: JAMA (1977)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstracts
Journal: Annals of the Rheumatic Diseases (1953)

One of the most difficult problems in the diagnosis of chronic constrictive pericarditis arises when this condition is associated with rheumatic heart disease.In a series of eighteen cases of constrictive pericarditis seen at the Veterans Administration Hospital, Bronx, N.Y., and proven at operation or necropsy, a cause was clearly apparent in only three cases, namely, tuberculosis in two cases and the presence of a foreign body in one.Among the remainder, five cases were associated with rheumatic heart disease, and these cases are described in detail.All five patients were men.Two were improved by pericardectomy, and had the physical signs of mitral and aortic valve lesions, although no history of rheumatism was obtained.The other three died without operation, and post-mortem examination showed a grossly thickened adherent pericardium causing constriction in all three cases, as well as rheumatic carditis with valvular lesions.All had considerable cardiac eftlargement, obvious clinically, with greatly raised venous pressure, chronic pulmonary congestion, and increased pulse pressure, and two patients had ascites.The authors do not consider that the constrictive pericarditis was necessarily rheumatic in origin.They point out, however, that a clinical diagnosis of constric- tive pericarditis is not excluded by the coexistence of rheumatic heart disease, heart sounds of normal intensity, and considerable cardiac enlargement.J. A. Cosh.
Selective serotonin reuptake inhibitors (SSRIs) and suicide in adults: meta-analysis of drug company data from placebo controlled, randomised controlled trials submitted to the MHRA's safety review
Journal: BMJ (2006)

reports of hip protectors, which absorb or spread the energy of a fall, were promising, but recent studies have questioned their effectiveness. 20 21 ConclusionsHip fracture is the most common disabling injury and cause of accidental death in older people.The incidence and the public health and economic consequences of this injury have risen as the population has aged, and this is expected to continue for the foreseeable future.The prevention and management of hip fractures involves a wide range of disciplines, and most people who sustain the injury require surgery followed by a period of rehabilitation.The complexity of care needed for hip fractures makes the condition a real test and a useful marker of the integration and effectiveness of modern health care.Competing interests: None declared by MP.AJ
Uninsured children. An unintended consequence of health care system reform efforts
Authors: S. Berman
Journal: JAMA (1995)

How well does our current health care system care for children? The article by Kogan et al<sup>1</sup>in this issue ofTHE JOURNALprovides information needed to answer this critical question. The article increases our understanding of three key issues related to health care system reform for children: first, the health impact of gaps in insurance coverage for young children; second, the extent of the problem with respect to the number of children affected and the duration of their gap in coverage; and third, the sociodemographic characteristics of children and families most likely to experience gaps in coverage. <h3>Understanding the Health Impact of Gaps in Insurance Coverage</h3> Having a gap in coverage affects access to and quality of needed medical care through two pathways: first, it requires financially strapped families to pay out-of-pocket for services; and second, it makes maintaining a continuous relationship with a primary care physician much
Medical Drama
Authors: Kristina M. Chongsiriwatana
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Role in nitric oxide in Kupffer cell-mediated hepatoma cell cytotoxicityin vitro andex vivo
Authors: D Fukumura, Y Yonei, I Kurose, H Saito, T Ohishi, H Higuchi, S Miura, S Kato, H Kimura, H Ebinuma, H Ishi
Journal: Hepatology (1996)

The metabolic change in tumor cells (AH70, a rat hepatoma cell line) cocultured with isolated rat Kupffer cells were visualized and analyzed by a laser scanning confocal imaging system. When AH70 cells were cocultured with Kupffer cells, fluorescence intensity of rhodamine 123 (Rh123) decreased, indicating the reduction of mitochondrial function. The reduction in Rh123 was eliminated by NG–monomethyl–L–arginine (L– NMMA), an analogue of L–arginine, suggesting the involvement of nitric oxide (NO). Two hour after the cells were cocultured, membrane compromised AH70 cells which were observed as propidium from 2.8% to 25%. This increase was also attenuated by L–NMMA, suggesting that Kupffer cell–mediated injury of tumor cells largely depends on NO. The concentrations of NO–2 + NO–3 in the culture medium markedly increased after coculture of AH70 cells with Kupffer cells. Moreover, NO synthase (NOS) activity in Kupffer cells significantly increased after coculture. These in vitro results suggest that NO mediates Kupffer cell– induced tumor cell damage characterized by reduced mitochondrial function and diminished barrier function. In the ex vivo study of the perfused liver to which AH70 cells were injected via the catheter inserted into the portal vein, some AH70 cells were arrested in the upper stream of sinusoid and the fluorescence intensity of Rh123 in adherent AH70 cells decreased in a time–dependent manner within 2 hours. The number of PI–positive AH70 cells also increased 2 hours after the injection of AH70 cells. These changes were inhibited by either administration of N omega–L–nitroarginine–methylester (L–NAME) to perfusate or pretreatment of the rat liver with GdCl3, which is known to deplete Kupffer cell function. Thus, the present study suggests that NO from Kupffer cells induces mitochondrial dysfunction in tumor cells followed by membrane barrier dysfunction in the liver sinusoid.
THE INFLUENCE OF CAFFEIN ON MENTAL AND MOTOR EFFICIENCY AND ON THE CIRCULATION
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Class war
Authors: Kieran Walsh
Journal: BMJ (2006)

in the airways and help patients expectorate.Despite these drugs having no effect on lung function, some studies have found that their regular use reduces the frequency of exacerbations of COPD and is associated with fewer days of ill health.Two mucolytic agents are currently licensed for use in the United Kingdom (carbocisteine and mecysteine hydrochloride) and are generally well tolerated.They may be tried in patients with productive cough who are troubled by frequent exacerbations, although further data are required to clarify their place in COPD management.Increased oxidative stress has been implicated in the inflammatory response in COPD, and N{acetyl cysteine, another mucolytic, may confer some benefit in terms of its antioxidant properties.
Correction: Geographic and Temporal Trends in the Molecular Epidemiology and Genetic Mechanisms of Transmitted HIV-1 Drug Resistance: An Individual-Patient- and Sequence-Level Meta-Analysis
Authors: Soo-Yon Rhee, Jose Luis Blanco, Michael R. Jordan, Jonathan Taylor, Philippe Lemey, Vici Varghese, Raph L. Hamers, Silvia Bertagnolio, Tobias F. Rinke de Wit, Avelin F. Aghokeng, Jan Albert, Radko Avi, Santiago Avila-Rios, Pascal O. Bessong, James I. Brooks, Charles A. B. Boucher, Zabrina L. Brumme, Michael P. Busch, Hermann Bussmann, Marie-Laure Chaix, Bum Sik Chin, Toni T. D’Aquin, Cillian F. De Gascun, Anne Derache, Diane Descamps, Alaka K. Deshpande, Cyrille F. Djoko, Susan H. Eshleman, Herve Fleury, Pierre Frange, Seiichiro Fujisaki, P. Richard Harrigan, Junko Hattori, Africa Holguin, Gillian M. Hunt, Hiroshi Ichimura, Pontiano Kaleebu, David Katzenstein, Sasisopin Kiertiburanakul, Jerome H. Kim, Sung Soon Kim, Yanpeng Li, Irja Lutsar, Lynn Morris, Nicaise Ndembi, Peng NG Kee, Ramesh S. Paranjape, Martine Peeters, Mario Poljak, Matt A. Price, Manon L. Ragonnet-Cronin, Gustavo Reyes-Terán, Morgane Rolland, Sunee Sirivichayakul, Davey M. Smith, Marcelo A. Soares, Vincent V. Soriano, Deogratius Ssemwanga, Maja Stanojevic, Mariane A. Stefani, Wataru Sugiura, Somnuek Sungkanuparph, Amilcar Tanuri, Kok Keng Tee, Hong-Ha M. Truong, David A. M. C. van de Vijver, Nicole Vidal, Chunfu Yang, Rongge Yang, Gonzalo Yebra, John P. A. Ioannidis, Anne-Mieke Vandamme, Robert W. Shafer
Journal: PLoS Medicine (2015)
Transfusion, Milwaukee
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Amiodarone.
Authors: G Breithardt, L Seipel, H Kuhn
Journal: Circulation (1980)

We read with great interest the recent paper by C6t6 et al.1 on the effects of amiodarone on cardiac and coronary hemodynamics and metabolism in patients with coronary artery disease.The authors reported a significant drop in aortic and left ventricular pressures after intravenous injection of amiodarone.Furthermore, systemic vascular resistance was found to fall significantly, while cardiac in- dex increased slightly but significantly.A similar study (referenced by C6te et al.) had been reported by Sicart et al.2In this study, 20 patients received amiodarone in- travenously at a dose of 5 and 10 mg/kg.These authors found a fall in peripheral resistance at a dose of 5 mg/kg, as did C6te et al.The contractility indices did not change.Heart rate increased tran- siently.However, at a dose of 10 mg/kg, there was a biphasic response with an increase in cardiac index and a decrease in peripheral resistance during the first 4 minutes after injection.This was followed by an increase in end-diastolic left ventricular pressure and a decrease in left ventricular contractility.Heart rate markedly increased during the first 3 minutes, and decreased after 3-5 minutes.In one subgroup of patients, the authors showed that the first phase after injection was due to the solvent (Tween 80), which counterbalanced the negative-inotropic effect of amiodarone.This latter effect became apparent only in the later phase of the study.
Symposium on Epstein-Barr Virus
Journal: JNCI Journal of the National Cancer Institute (1986)

Journal Article Symposium on Epstein-Barr Virus Get access JNCI: Journal of the National Cancer Institute, Volume 77, Issue 1, July 1986, Page 309, https://doi.org/10.1093/jnci/77.1.309-d Published: 01 July 1986
Lectures on the History of Medicine
Authors: A. Henry
Journal: BMJ (1860)

3azws Mmw 3Iuaw-LXTSUS '(Er.13,laf Xh incisions, bowever, being made more reely, but not carried so far forwads as to endanger the anterior crural, or so far back as to wound the sciatic nerve.After the removal of the hed of the femur, all loose pieces of necrosed bone are to be taken out, and then, by means of ordinary cutting or gouge forceps, the acetabulum and other diseased osseous strctures out away piecemeal.In doing this, it will be found that the neroed bone readily separtes by means of tbe fnger, or by the handle of a scalpel, from the subjacent soft structures; ad the muscles and fasoise lining the pelvic bones, being thick- ened and infiltrated with lymph, effectually protect the con- taied parts from all ijury.The result of excision of the hip-joint has to be considered from two points of view: 1.So far as the mortality immedi- ately referrible to the operation is concerned; and 2. As to the utility of the limb that is left after its performance.
STUDIES OF LUNG VOLUME. I
Authors: Christen Lundsgaard, Donald D. Van Slyke
Journal: The Journal of Experimental Medicine (1918)

On page 65, Vol. XXVII, No. 1, January 1, 1918, the last two sentences of the second paragraph should read: The difference between the total capacity and the middle capacity (all that can be breathed in after a half expiration) is called the "complementary air."2 The difference between middle capacity and residual air (all that can be breathed out after a half expiration) is called the "reserve air."
Mesenteric Ischemia
Authors: Leslie W. Ottinger
Journal: New England Journal of Medicine (1982)

Acute Mesenteric IschemiaBecause of its varied presentations, multiple causes, and high mortality rate, acute mesenteric ischemia remains a very difficult clinical problem. Its complexity in part reflects the fact that although obstruction of mesenteric arterial and venous flow has a primary role in the ischemia, inadequate collateral flow, arterial spasm, and a decrease in perfusion pressure at times initiate or accentuate the extent of the ischemic injury.Of the cases of acute mesenteric infarction diagnosed before death, about half have been due to superior mesenteric artery occlusion, one fourth to nonocclusive infarction, and one fourth to inferior mesenteric artery . . .
A Practical Treatise on the Diseases of the Hair and Scalp.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Artistic License
Authors: George B. Markle
Journal: JAMA (1975)

<h3>To the Editor.—</h3> The cover on the Jan 6 issue ofThe Journal, Piloty's dramatic portrait, "Columbus' First Glimpse of the New World," was an excellent choice. It tells a great story, depicts an inspired and magnificent character, and is artistically an excellent work. This is the sort of art that many of us amateur artists of the old school can only envy and admire. The diagnosticians among us, however, might point out several points of artistic license that the painter evidently took. Noting the position of the moon (as indicated by the shadows) and the constellation Orion, one should deduct that at this moment Columbus was evidently sailing east, not west, and that he was apparently in a northern latitude, probably 40° north, nowhere near San Salvador. I'm sorry I can't tell at what longitude. The time would have been about 11 PM, I think, since at that time
Laparoscopic Gastrostomy
Authors: J. Clark, R. A. Pugash
Journal: Endoscopy (2002)

As physicians with a keen interest in gastrostomy, we were interested to read about Raakow and colleagues' experience with laparoscopic gastrostomy [1], but we were surprised by the inexplicable absence from their discussion of radiologic gastrostomy as a viable option for feeding tube placement. Radiologists in our department have been performing fluoroscopically guided gastrostomy and gastrojejunostomy on an almost daily basis for the last 17 years. Even if radiologic gastrostomy is unavailable to Raakow et al., we believe that it warrants inclusion in their discussion.