tbuckley/cabot-search huggingface dataset:
Attachment Disorder
Authors: Risa Denenberg
Journal: Annals of Internal Medicine (2012)

Ad Libitum1 May 2012Attachment DisorderRisa Denenberg, NP, MSNRisa Denenberg, NP, MSNFrom Tacoma, WA 98405.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-156-9-201205010-00015 Audio Reading - “Attachment Disorder” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Attachment Disorder," by R. Denenberg. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Let us pee, mother says without irony,as she hovers to see what the childwill do. She has a tendency, at three,to wet her panties, if not hard-pressed.More worrisome is the way she refusesall touch—hugs, kisses, cuddles. The wordautism is bandied about the house. Mother'sdespair is somewhat relieved with the arrivalof a new baby boy. And later, the girl appearsto adjust, even does quite well in grade school.Although she does have a tendency, which persistsinto middle age, to avoid touch, and even moredepopulate her ... Author, Article, and Disclosure InformationAffiliations: From Tacoma, WA 98405.Current Author Address: Risa Denenberg, NP, MSN; e-mail, [email protected]com. PreviousarticleNextarticle Advertisement Audio Reading - “Attachment Disorder” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Attachment Disorder," by R. Denenberg. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 1 May 2012Volume 156, Issue 9Page: 667KeywordsAutismNursesTouch ePublished: 1 May 2012 Issue Published: 1 May 2012 Copyright & PermissionsCopyright © 2012 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Immunological and virological clues for mother-to-child transmission of HIV-1 and HIV-2
Authors: S. D. Douglas
Journal: JAMA (1994)

There will be more than 15 million women infected with human immunodeficiency virus type 1 (HIV-1), 3 million HIV-positive infants, and more than 2 million children with pediatric acquired immunodeficiency syndrome (AIDS) worldwide by the year 2000, according to estimated projections.<sup>1</sup>The rate of transmission of HIV-1 from an infected woman to her fetus or infant ranges from 13% to 32% in industrialized countries to 25% to 48% in developing countries.<sup>1</sup>In addition to HIV-1, a second virus causing AIDS, HIV type 2 (HIV-2) has been isolated from individuals from Guinea Bissau, The Gambia, and the Ivory Coast, West Africa. Differing from HIV-1 strains by more than 55% in sequence analysis, HIV-2 may have a different immunopathogenesis than HIV-1. In this issue ofTHE JOURNAL, Adjorlolo et al<sup>2</sup>report perinatal transmission in dually infected women (determined by polymerase chain reaction analysis of leukocytes) from a lower socioeconomic
CANINE HEMOPHILIA
Authors: H C LEOPOLD, B GODWIN
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Management of cervical and mediastinal lesions of the trachea
Authors: H. C. Grillo
Journal: JAMA (1966)

Although many tracheal tumors are benign or of low-grade malignancy, without local invasion or metastases, cure has been rare because dependable methods of wide circumferential excision and reconstruction have not been available. In the thorax, it was believed that only four tracheal rings (2 cm) could be removed and an end-to-end anastomosis done. Prosthetic replacements often fail, because of (1) leakage, with fatal mediastinitis; (2) stenosis, due to scarring and fatigue of prostheses; (3) recurrent tumor, due to inadequate resection; and (4) hemorrhage, due to erosion by prostheses. In the neck, reconstructive methods have often been complex, slow to heal, and many-staged. Excision of the trachea without replacement—with permanent end-tracheostomy—is not satisfactory when a functional larynx remains. Review of past experience with 32 primary tumors of the trachea treated at the Massachusetts General Hospital and the Massachusetts Eye and Ear Infirmary, Boston, during a period of 25 years reveals that
Reflections on a century of excellence
Authors: M. A. Madoff
Journal: JAMA (1993)

In many ways, Tufts University School of Medicine, Boston, Mass, has never gotten over the manner in which it was founded a century ago. For a multitude of reasons, I hope it never does. By 1893, the College of Physicians and Surgeons, a Boston medical school of unsteady reputation, had settled into a kind of terminal complacency. Its outmoded facilities and undemanding curriculum were a growing source of discontent, perhaps of embarrassment, to its leading faculty members. Administratively unwieldy and academically staid, it hardly seemed the sort of institution capable of competing with the widening ranks of university-affiliated medical schools. Seven of the college's most esteemed faculty members, prominent Boston physicians, petitioned the trustees of Tufts College for permission to incorporate a new medical school under Tufts' aegis. "We propose to furnish a building, equipment, and everything necessary to carry on the work of a first-class medical school without any
Interaction of COMT Val108/158 Met Genotype and Olanzapine Treatment on Prefrontal Cortical Function in Patients With Schizophrenia
Authors: A. Bertolino
Journal: American Journal of Psychiatry (2004)

OBJECTIVE: Deficits in working memory and in prefrontal cortical physiology are important outcome measures in schizophrenia, and both have been associated with dopamine dysregulation and with a functional polymorphism (Val108/158Met) in the catechol O-methyltransferase (COMT) gene that affects dopamine inactivation in the prefrontal cortex. The purpose of the present study was to evaluate in patients with schizophrenia the effect of COMT genotype on symptom variation, working memory performance, and prefrontal cortical physiology in response to treatment with an atypical antipsychotic drug. METHOD: Thirty patients with acute untreated schizophrenia were clinically evaluated with the Positive and Negative Syndrome Scale, underwent COMT Val/Met genotyping, and entered an 8-week prospective study of olanzapine treatment. Twenty patients completed two 3-T functional magnetic resonance imaging scans at 4 and 8 weeks during performance of N-back working memory tasks. RESULTS: There was a significant interaction of COMT genotype and the effects of olanzapine on prefrontal cortical function. Met allele load predicted improvement in working memory performance and prefrontal physiology after 8 weeks of treatment. A similar effect was found also for negative symptoms assessed with the Positive and Negative Syndrome Scale. CONCLUSIONS: These results suggest that a genetically determined variation in prefrontal dopamine catabolism impacts the therapeutic profile of olanzapine.
Acute Symptoms Following Exposure to Grain Dust in Farming
Authors: J. Manfreda, V. Holford-Strevens, M. Cheang, C. P. W. Warren
Journal: Environmental Health Perspectives (1986)

History of acute symptoms (cough, wheezing, shortness of breath, fever, stuffy nose, and skin itching/rash) following exposure to grain dust was obtained from 661 male and 535 female current and former farmers. These symptoms were relatively common: 60% of male and 25% of female farmers reported at least one such symptom on exposure to grain dust. Association of cough, wheezing, shortness of breath, and stuffy nose with skin reactivity and capacity to form IgE is consistent with an allergic nature of these symptoms. Barley and oats dust were perceived as dust most often producing symptoms. On the other hand, grain fever showed a different pattern, i.e., it was not associated with either skin reactivity or total IgE. Smoking might modify the susceptibility to react to grain dust with symptoms. Only those who reported wheezing on exposure to grain dust may have an increased risk to develop chronic airflow obstruction.
THE AUGUST HEAT.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diseases of the Colon and Rectum, Philadelphia
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Unreported Financial Disclosures in: Association of LDL Cholesterol, Non–HDL Cholesterol, and Apolipoprotein B Levels With Risk of Cardiovascular Events Among Patients Treated With Statins: A Meta-analysis
Journal: JAMA (2012)

Association of LDL Cholesterol, Non–HDL Cholesterol, and Apolipoprotein B Levels With Risk of Cardiovascular Events Among Patients Treated With Statins
Therapy with Fludarabine, Cyclophosphamide and Rituximab (FCR) for Relapsed or Untreated Progressive Chronic Lymphocytic Leukemia (CLL). A Single Center Experience.
Authors: Carolina Pavlovsky, Santiago Pavlovsky, Maria L. Pardo, Sandra Sapia, Mariela Monreal, Claudia Corrado, Miguel A. Pavlovsky, Isolda Fernandez, Mariana Juni
Journal: Blood (2006)
Evidence for major gene transmission of developmental dyslexia
Authors: B F Pennington, J W Gilger, D Pauls, S A Smith, S D Smith, J C DeFries
Journal: JAMA (1991)

<h3>Objective.</h3> —There is strong evidence that developmental dyslexia is both familial and heritable, but the mode of genetic transmission has remained unclear. In this article, we examine specific genetic hypotheses about the mode of transmission of developmental dyslexia by performing complex segregation analyses. <h3>Design.</h3> —A family study method was applied, whereby the relatives of dyslexic probands were examined for dyslexia. The families studied represent four independently ascertained samples. <h3>Setting.</h3> —The four samples of families were primarily from rural and suburban communities of Colorado, Washington State, and Iowa. <h3>Participants.</h3><h3>— A total of 204 families and 1698 individuals in the four samples combined.</h3><h3>Main Outcome Measures.</h3> —The complex segregation program, POINTER, was used to test competing genetic hypotheses of how a categorical trait (dyslexia) is transmitted in families. <h3>Results.</h3> —The results were consistent with major locus transmission in three of four samples and with polygenic transmission in the fourth. In these three samples, the estimates of penetrance for the<i>AA, Aa</i>, and<i>aa</i>genotypes (where<i>A</i>is the abnormal allele) were, respectively, 1.000, 1.000, and 0.001 to 0.039 in males, and 0.560 to 1.000, 0.550 to 0.897, and 0.000 in females. The estimated gene frequency of the major locus was between 3% and 5%. <h3>Conclusions.</h3> —Sex-influenced, additive, or dominant transmission occurs in a significant proportion of dyslexic families. Other evidence indicates, however, that dyslexia is etiologically heterogeneous and that there is genetic heterogeneity even among families selected for apparent dominant transmission. Thus, while no single major locus may account for all of dyslexia, it is important to pursue potential major loci for dyslexia using linkage techniques. (JAMA. 1991;266:1527-1534)
Decreased Lymphocyte Responses in Free-Ranging Bottlenose Dolphins (Tursiops truncatus) Are Associated with Increased Concentrations of PCBs and DDT in Peripheral Blood
Authors: Garet P. Lahvis, Randall S. Wells, Douglas W. Kuehl, Jennifer L. Stewart, Howard L. Rhinehart, Charles S. Via
Journal: Environmental Health Perspectives (1995)
Carbon Monoxide
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Displaced Heart.
Authors: John Little
Journal: JAMA (1902)

Bloomington, Ill., Feb. 6, 1902. <h3>To the Editor:</h3> —On November 27, 1901, G. W. H., late private in the Illinois Cavalry, came before the Board of U. S. Examining Surgeons at Bloomington, Ill., for examination for an increase of pension. He was born in Illinois, and has always lived in this state, except when he was in the Union Army from 1861 to 1864. He is 58 years old, weighs 150 pounds, and is 5 feet and 7% inches high; he has blue eyes, gray hair, light complexion, and is by occupation a carpenter. He complained of chronic rheumatism, disease of the digestive organs, abdominal hernia, injury to back, fracture of both bones of left leg, and debility from old age. The apex impulse of the heart was evident on inspection and palpation in the fifth intercostal space one inch to the left of the right nipple line. The area
SPECIAL NOTICE.
Journal: JAMA (1889)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Regulation of Stat3 nuclear export
Authors: Samita Bhattacharya, Christian Schindler
Journal: Journal of Clinical Investigation (2003)

Stat3 is the most pleiotropic member of the signal transducer and activator of transcription (STAT) family of transcription factors and mediates pivotal responses for the cytokine family. In resting cells, STATs, including Stat3, reside largely in the cytoplasm. Upon cytokine stimulation, they rapidly translocate to the nucleus, where they promote the expression of target genes. During the subsequent period of signal decay they are re-exported back to the cytoplasm in preparation for the next round of signaling. This process of nuclear export can be blocked by the fungal toxin leptomycin B (LMB). In contrast to what appears to be the case for Stat1, LMB treatment not only blocks the poststimulation export of Stat3 from the nucleus back to the cytoplasm, but also promotes the nuclear accumulation of Stat3 in resting cells. Remarkably, the LMB-dependent nuclear accumulation of Stat3 in resting cells is independent of tyrosine phosphorylation, highlighting the existence of a “basal” signaling pathway. Subsequent studies identified three nuclear export signal (NES) elements. Two of these elements, Stat3306–318 and Stat3404–414, corresponded to those recently identified in Stat1, and a third, Stat3524–535, is novel. Stat3306–318 appears to be important in the rapid nuclear export seen after stimulation (poststimulation export), whereas the Stat3404–414 and Stat3524–535 play a more important role in regulating basal nuclear export. In summary, these studies indicate that the process of Stat3 nuclear export is dependent on multiple NES elements.
Beta-Carotene Didn't Prevent Cancer: What's Up Doc?
Authors: S. M. LIPPMAN, W. K. HONG
Journal: JNCI Journal of the National Cancer Institute (1991)

Journal Article Beta-Carotene Didn't Prevent Cancer: What's Up Doc? Get access SCOTT M. LIPPMAN, SCOTT M. LIPPMAN Search for other works by this author on: Oxford Academic PubMed Google Scholar WAUN KI HONG WAUN KI HONG Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 15, 7 August 1991, Page 1111, https://doi.org/10.1093/jnci/83.15.1111-a Published: 07 August 1991
Secret Pain
Authors: Linda Barthauer
Journal: JAMA (1990)

I walked tentatively into the front room of the local women's center. Two women waited inside. One sat stooped in a chair; she appeared to contemplate her feet. The other was paced, alternately taking hits from a soda and a cigarette. It was Tuesday afternoon. At last, there were nine of us, from varied backgrounds and life-styles but sharing one characteristic: we were survivors of childhood sexual abuse. Over the next months we each related our experiences, our pain, our hope now for better lives. As we described our pasts and our attempts to seek help, I realized how poorly medical and psychiatric practitioners are equipped to handle the physical and emotional wounds of abuse in adult survivors. I vowed then to devote part of my professional energy to educating my peers. My own experience with abuse, or rather the process of digging it up from the recesses of memory, began last year, in the middle of my second year of medical school. I had developed a terrible choking feeling at night, sometimes so severe I couldn't sleep. I also had several vivid, disturbing dreams.