tbuckley/cabot-search huggingface dataset:
Modern Drug Encyclopedia and Therapeutic Guide Presenting Descriptions of 11,114 Modern, Nonpharmacopeal, Ethical Medicinal Preparations in 15,629 Forms, Comprising: 3,421 Drugs and Chemicals, 663 Biologicals, 691 Endocrines, 2,270 Ampoule Medicaments, 3,190 Individual and Group Allergens and 879 Miscellaneous Products
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SONNE DYSENTERY
Authors: JOSEPH FELSEN
Journal: JAMA (1934)

Sonne dysentery is an inflammatory condition of the small and large intestine characterized by a bloody and mucoid diarrhea accompanied by colic, having a short incubation period and being of a relatively nontoxic type. The disease is caused by the Bacillus dysenteriae of Sonne, which has many points of clinical, cultural and agglutination similarity to the organism causing the Flexner type of dysentery, for which it is often mistaken. Our purpose in this communication is to present the general subject of Sonne dysentery and the detailed clinical, bacteriologic and experimental studies of a recent outbreak. The disease has been practically unknown in the United States. There is reason for believing, however, that this distinctive type of dysentery has been overlooked, that it is endemic in many parts of this country, that it can assume epidemic proportions and that there is a possible connection with certain intestinal and arthritic diseases of
AMA Insights
Journal: JAMA (1979)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Modern Practice in Infectious Fevers. Vols. I &amp;amp; II
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 1957: Novel substrates for NanoLuc luciferase with improved brightness and signal duration for bioluminescence imaging <i>in vivo</i>
Authors: Joel R. Walker, Yunhee Park, Michael Lin, Thomas A. Kirkland, Mary P. Hall, Lance P. Encell, Younghee Oh, Lan Liu
Journal: Cancer Research (2019)

Abstract NanoLuc® luciferase, and its substrate furimazine, are becoming a preferred bioluminescent system in cellular and biochemical assays due to its brightness and glow-type kinetics. The construct Antares, made by fusing NanoLuc to the cyan-excitable orange-red fluorescent protein CyOFP, combines the high catalytic rate of NanoLuc with the high quantum yield and red-shifted emission of CyOFP (584 nm), which is well suited for in vivo imaging. Transgenic mice were created to constituently express Antares and these mice were used to screen coelenterazine analogues for a substrate that showed appropriate distribution and brightness in vivo. Our new Antares (NanoLuc) substrates are administered i.p., have improved solubility over furimazine, exhibit long (&amp;gt;30 min) signal kinetics, and are brighter than D-luciferin/Luc2 expressed on the same promoters. Citation Format: Joel R. Walker, Yunhee Park, Michael Lin, Thomas A. Kirkland, Mary P. Hall, Lance P. Encell, Younghee Oh, Lan Liu. Novel substrates for NanoLuc luciferase with improved brightness and signal duration for bioluminescence imaging in vivo [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1957.
Noise Pollution
Authors: Charles B. Upshaw
Journal: JAMA (1968)

<h3>To the Editor:—</h3> I take exception to your editorial, "Noise Pollution" (<b>205</b>:928, 1968). Excessive noise is a very real social and medical problem. It interferes with our ability to carry on a conversation, it causes the ears and head to ache, and it causes mental and physical fatigue. Excess noise traumatizes the hearing apparatus causing variable degrees of deafness, frequently early in life. All too often the hearing loss occurs in the range of human conversation and thus does affect the ability to communicate. Deafness also may affect our ability to earn a living. I have been impressed by the psychological damage that occurs to a deaf person as a result of his inability to hear the accustomed noises of his environment. Further, the inability to communicate with his fellow men may cause emotional injury. Noise pollution is real and a damaging factor in our society.
Abstract 301: Concurrent targeting of BMI1 and CDK4/6 inhibited breast cancer tumorigenicity in vitro and in vivo
Authors: Nehad M. Alajez
Journal: Cancer Research (2019)

Abstract Despite recent advances in cancer management and therapy, resistance to cytotoxic medications remains a major clinical challenge. Intratumoral heterogeneity appears to play crucial role in drug resistance; therefore, combination-based approaches are currently gaining momentum. In the current study, we investigated the ramifications of concurrent targeting of tumor-initiating cells (using BMI1 specific inhibitor, PTC-209) and cell cycle progressiontargeting CDK4/CDK6 using palbociclib on breast, colorectal and prostate cancer cell growth in vitro and in vivo. PTC-209 reduced BMI1 protein expression, while palbociclib (PB) inhibitedCDK4, Rb, and PRb Ser795 phosphorylation. PTC-209 and palbociclib exhibited dose-dependent cytotoxic effects against MDA-MB-231, HCT-116, and PC-3 cell models, which was more profound in the combination group. Global gene expression profiling in MDA-MB-231 treated with PTC-209 revealed multiple affected cellular pathways including insulin signaling, focal adhesion, DNA damage response, and Wnt/pluripotency. On the other hand, PB treatment ofMDA-MB-231 led to substantial changes in gene expression affecting mainly cell cycle progression. PTC-209 and palbociclib reduced colony formation potential, sphere formation, cell migration, and cell viability, which was further enhanced in the combination group. Consistent with our results in vitro, combination treatment of PTC-209 and palbociclib reduced tumor growth more profoundly than either of these drugs alone in in vivo model of MDA-MD-231 cells. Therefore, our data suggest concurrent targeting of BMI1 and CDK4/CDK6 might provide novel therapeutic opportunity for breast, colorectal, and prostate cancer. Citation Format: Nehad M. Alajez. Concurrent targeting of BMI1 and CDK4/6 inhibited breast cancer tumorigenicity in vitro and in vivo [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 301.
INFANT FEEDING IN HOT WEATHER.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medicolegal
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dermatopathic lymphadenitis presenting as lateral breast mass
Authors: A. D. Heymann
Journal: JAMA (1978)

Two cases of dermatopathic lymphadenitis involved external mammary lymph nodes and presented clinically as breast masses. The variable position and number of external mammary lymph nodes account for the difficulty in differentiating intrinsic breast pathological conditions of the lateral margin of the breast from lymphadenitis. Recent publicity may account for a lower threshold for detection of such lesions by patients as well as physicians. Dermatopathic lymphadenitis should be included in the differential diagnosis of persistent solid masses involving the lateral margin of the breast and should be confirmed by excisional biopsy. (<i>JAMA</i>240:1622-1623, 1978)
Dr. A. E. H. Kendall
Journal: British Journal of Sports Medicine (1971)

medicine first in Sydney, then London, and qualified in 1923.He obtained the Fellowship of the Royal College of Surgeons of Edinburgh in 1928, but spent most of his professional life in London.After the war he was one of that group of specialists in various branches of medicine who moved into the new specialist field of physical medicine.His earlier background in Australia, with his later interests in rehabilitation, made him a most valuable adviser to the Amateur Swimming Association, and he was a prime mover in the physiological assessment of the athlete, and the assessment of his physical fitness by objective tests administered by the coaches.He was a founder member of the B.A.S.M.Dr. Kendall 's many visits to Loughborough whenever young swimmers were undergoing courses of intensive training, and whenever coaches were being trained, gave a stimulus to the scientific approach to training and fitness, measurement that spread to many sports outside swimming.I myself feel a deep debt of gratitude to Dr. Kendall for introducing me to this field, and for his encouragement over many years.Besides his physiological interests, Dr. Kendall also put his extensive clinical experience at the disposal of the swimmers, and was one of those who pioneered a high level of medical care for the athletic team.He was a good teacher and very fair examiner for those taking coaching wards, and he was one of that devoted band of officials who was always willing, to hold a stopwatch or to do any other task required during competitions.He encouraged his son Patrick to become a swimmer of repute and received all our sympathy on Patrick 's tragic death three years ago.The deaths of son then father, so close together, leave a large gap in sports medicine, and in Physical medicine in this country.H. E. R.
Transfusion, Milwaukee
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
External validation of the VENUSS prognostic model to predict disease recurrence after surgery for non-metastatic papillary renal cell carcinoma: An analysis of a multi-institutional European cohort
Authors: S. Erdem, U. Capitanio, R. Campi, M.C. Mir, R. Eduard, N. Pavan, O. Kara, T. Klatte, M.C. Kriegmair, E. Degirmenci, R. Aydin, A. Minervini, S. Serni, G. Rebez, F. Ozcan
Journal: European Urology (2021)
Hyperthyroidism
Authors: Michael T. McDermott
Journal: Annals of Internal Medicine (2020)

Thyrotoxicosis is a general term for excess circulating and tissue thyroid hormone levels, whereas hyperthyroidism specifically denotes disorders involving a hyperactive thyroid gland (Graves disease, toxic multinodular goiter, toxic adenoma). Diagnosis and determination of the cause rely on clinical evaluation, laboratory tests, and imaging studies. Hyperthyroidism is treated with antithyroid drugs, radioactive iodine ablation, or thyroidectomy. Other types of thyrotoxicosis are monitored and treated with β-blockers to control symptoms given that most of these conditions resolve spontaneously.
The tyranny of standards
Authors: W. R. Fifer
Journal: JAMA (1975)

IMPROVING medical care quality is a goal shared by the physician, the patient, and the bill payer. The ability to do so first of all, implies knowledge of the current quality of care level, and second, existence of mechanisms to alter substandard conditions. Quality has been defined as "the degree of adherence to a standard," and assessing the quality of medical care generally involves comparing actual care with some standard or criterion of excellence. Differences between the real and the stated ideal are then analyzed and deficiencies identified. Improved quality is determined by increased compliance with standards at the time of reassessment. We are rapidly being surrounded by standards or criteria designed for use in determining the necessity of hospital admission, appropriateness of medical service utilization, and quality of care. Criteria sets are being prepared by professional specialty societies, foundations for medical care, and experimental medical care review organizations. The
Ex Vivo Generation Of CD4+ T Cells To Prevent and Treat Infection From Antibiotic-Resistant Klebsiella Pneumoniae In Immunocompromised Patients
Authors: Manuel Franco-Colon, Kong Chen, Dhanalakshmi Chinnasamy, Marianna Sabatino, David Stroncek, Sawa Ito, Tara Palmore, Jay Kolls, A. John Barrett, Pawel Muranski
Journal: Blood (2013)
Introduction
Authors: F.H. Roldan, H. Warnes, J. Blustein, Herbert Weiner, Zbigniew J. Lipowski, Juan J. López-Ibor, Cairns Aitken, Giovanni A. Fava, Thomas N. Wise, Walter Vandereycken, A. Singer, S. Thompson, C. Kraiuhin, E. Gordon, G. Howe, A. Howson, R. Meares, Leigh James, Andrew Singer, Yvonne Zurynski, Evian Gordon, Claudia Kraiuhin, Anthony Harris, Alan Howson, Russell Meares, Vincenta Leigh, Sue Smolski, H.R. Winefield, A.H. Winefield, M. Tiggemann, S. Smith, Adam J. Krakowski
Journal: Psychotherapy and Psychosomatics (1987)
RONC-06. INCIDENCE OF CAVERNOMATOUS LESIONS ON BRAIN MR OF PEDIATRIC PATIENTS TREATED WITH INTRAVENTRICULAR RADIOIMMUNOTHERAPY
Authors: Kim Kramer, Suzanne Wolden, Maria Donzelli, Sofia Haque
Journal: Neuro-Oncology (2018)

Cerebral cavernomas are incidental findings in pediatric patients with primary or metastatic central nervous system (CNS) tumors. Lesional hemorrhage may lead to neurological compromise. The incidence of therapy related cavernomas in pediatric patients treated with intraventricular radio-labeled monoclonal antibodies has not been described. Patients treated on institutional clinical trials with 2- 5 serial intraventricular injections 124I- or 131I- labeled monoclonal antibodies (cRIT) targeting tumor associated antigens. Pre-treatment brain MR at baseline and periodically for follow up over several years were obtained. Brain MR with Gradient echo T2*-weighted imaging and susceptibility-weighted imaging was used to routinely identify therapy related caveromatous lesions. 80 patients treated with 2- 100 mCi cRIT were alive with follow-up MR imaging for assessment. Diagnoses included medulloblastoma, ependymoma, ATRT, choroid plexus carcinoma, and metastatic neuroblastoma, retinoblastoma and sarcoma; 70/80 (88%) had prior external beam radiotherapy. Median age at the time of cRIT was 7.6 years (9 mon-34.5 years). Median time for MR follow-up examinations was 38.4 mon from the time of first cRIT. Cavernomatous lesions were detected in 17/80 patients (21%), all in patients with external beam radiotherapy. Multiple supratentorial and infratentorial lesions were detected in 10 patients; 7 had unifocal cavernomas commonly in the frontal lobes. One patient with cavernomas and concurrent vasculitis had neurologic symptoms; remaining patients were asymptomatic. Cavernomatous lesions are found in up to 21% of survivors of pediatric CNS tumors treated with cRIT and external beam radiotherapy. Despite numerous lesions, patients remain without neurologic compromise.
Faster femoral artery blood velocity kinetics at the onset of exercise following short-term training
Authors: J Shoemaker
Journal: Cardiovascular Research (1996)

Objective: The hypothesis that the adaptation to endurance exercise training included a faster increase in blood flow at the onset of exercise was tested in 12 healthy young men who endurance-trained (ET) 2 h/day, for 10 days at 65% V̇O2 peak on a cycl and in 11 non-training control (C) subjects. Methods: Blood flow was estimated from changes in femoral artery mean blood velocity (MBV) by pulsed Doppler. Beat-by-beat changes in cardiac output (CO) and mean arterial pressure (MAP) were obtained by impedance cardiography and a Finapres finger cuff, respectively. MBV, MAP and CO were measured at rest and during 5 min of dynamic knee extension exercise. Both legs worked alternately with 2 s raising and lowering a weight (15% maximal voluntary contraction) followed by 2 s rest while the other leg raised and lowered the weight. Results: In the ET group the time to 63% (T63%) of the approximately exponential increase in MBV following 10 days of training (8.6 ± 1.2 s, mean ± s.e.) was significantly faster than the Day 0 response (14.2 ± 2.1 s, P < 0.05). The T63% of femoral artery vascular conductance (VCfa) was also faster following 10 days of ET (9.4 ± 0.9 s) versus Day 0 (16.0 ± 2.5 s) (0.05). There was no change in the T63% of both MBV and VCfa for the C group. The kinetics of CO were not significantly affected by ET, but the amplitude of CO in the adaptive phase, and at steady state, were significantly greater (P < 0.05) at Day 10 compared to Day 0 for the ET group with no change in the C group. Conclusions: These data supported the hypothesis that endurance training resulted in faster adaptation of blood flow to exercising muscle, and further showed that this response occurred early in the training program.
Behavior and Arteriosclerosis.
Journal: Annals of Internal Medicine (1984)

examination extremely helpful'.The text on page 101, on ulcerative colitis, is utterly meaningless to the English reader, as is the figure caption 'chronic ulcerative colitis in advanced regression of pseudopolypoid structures'.Apthoid ulcers (page 127) cannot by definition be linear, nor can they be 'oblong, wide, oval, polygonal or en cocarde'.These are not isolated examples and it is a pity that there is such a difference between the quality of the illustrations and the quality and sense of the text.Much of the text needs translating into medical English and hence the value of this book is questionable to those who are not already experienced in the field of colon radiology.