tbuckley/cabot-search huggingface dataset:
Advice
Authors: Ellen D Feld
Journal: Annals of Internal Medicine (2010)

On Being a Doctor5 January 2010AdviceEllen D. Feld, MDEllen D. Feld, MDFrom Drexel University, Philadelphia, PA 19102.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-152-1-201001050-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail We are taught that advice we give patients, no matter how brief or seemingly insignificant, strongly influences their behavior. But I have always had trouble believing this.I picked up Martin Pembroke during the first week of my residency. (At my hospital, first-year residents “picked up” indigent patients in the hospital's medical clinic, then cared for them during their 3 years of residency.) He had smoked for 62 years. Over those years, at least a dozen doctors told him to quit, to no avail. By the time I met Mr. Pembroke, he was tethered to an oxygen tank 24 hours ... Author, Article, and Disclosure InformationAffiliations: From Drexel University, Philadelphia, PA 19102.Corresponding Author: Ellen D. Feld, MD, Drexel University, PA Program, MS #504, 245 North 15th Street, Philadelphia, PA 19102; e-mail, [email protected]edu. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 5 January 2010Volume 152, Issue 1Page: 62KeywordsAlcoholismChartsEmergency departmentHeartHospitalsInflammationLungsOxygenPneumoniaResidency ePublished: 5 January 2010 Issue Published: 5 January 2010 Copyright & PermissionsCopyright © 2010 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Oxygen-Derived Species: Their Relation to Human Disease and Environmental Stress
Authors: Barry Halliwell, Carroll E. Cross
Journal: Environmental Health Perspectives (1994)

Free radicals and other reactive oxygen species (ROS) are constantly formed in the human body, often for useful metabolic purposes.Antioxidant defenses protect against them, but these defenses are not completely adequate, and systems that repair damage by ROS are also necessary.Mild oxidative stress often induces antioxidant defense enzymes, but severe stress can cause oxidative damage to lipids, proteins, and DNA within cells, leading to such events as DNA strand breakage and disruption of calcium ion metabolism.Oxidative stress can result from exposure to toxic agents, and by the process of tissue injury itself.Ozone, oxides of nitrogen, and cigarette smoke can cause oxidative damage; but the molecular targets that they damage may not be the same.-
Meeting Report: Nuclear Receptors: Transcription Factors and Drug Targets Connecting Basic Research with Translational Medicine
Authors: Jan Tuckermann, William Bourguet, Susanne Mandrup
Journal: Endocrine Reviews (2010)

Nuclear receptors (NRs) constitute a unique group of transcription factors. They act as sensors for metabolic as well as systemic hormonal signals and regulate a wealth of cellular processes from growth and differentiation to metabolism. Moreover, the fact that their activity can be pharmacologically modulated by specific ligands, thereby allowing for agonism, partial agonism, and antagonism, has made them primary therapeutic targets for decades. In addition, the ligand-dependence of most of their functions has also allowed using NRs as tools to generate paradigms for the molecular mechanisms of transcriptional regulation.
Corrections to “Phase I safety, pharmacokinetic and pharmacodynamic trial of BMS-599626 (AC480), an oral pan-HER receptor tyrosine kinase inhibitor, in patients with advanced solid tumors”
Authors: J.-C. Soria, J. Cortes, C. Massard, J.-P. Armand, D. De Andreis, S. Ropert, E. Lopez, A. Catteau, J. James, J.-F. Marier, M. Beliveau, R.E. Martell, J. Baselga
Journal: Annals of Oncology (2019)

Ann Oncol 2012; 23: 463–471 (doi: 10.1093/annonc/mdr137) In the original article, the disclosure was incomplete. This has now been updated to add the statement for J. Baselga: JB is the consultant and on the advisory board for Roche and Novartis. Phase I safety, pharmacokinetic and pharmacodynamic trial of BMS-599626 (AC480), an oral pan-HER receptor tyrosine kinase inhibitor, in patients with advanced solid tumorsAnnals of OncologyVol. 23Issue 2PreviewWe studied the safety, tolerability, and recommended dose of BMS-599626, an orally bioavailable inhibitor of the human epidermal growth factor receptor (HER) family of receptor tyrosine kinases. Full-Text PDF Open Archive
Value of Dextran Cited In Acute Thrombophlebitis
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE BASAL METABOLIC RATE IN HYPERTHYROIDISM
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Current Comment
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 902: A Beta-2 Adrenergic Receptor Polymorphism Is Associated With Increased Left Ventricular Remodeling Following First ST-Elevation Myocardial Infarction
Authors: Rhondalyn C McLean, Glenn A Hirsch, Gary Gerstenblith, Steven P Schulman
Journal: Circulation (2007)

Background: Prior studies demonstrate an association between specific β-adrenergic receptor polymorphisms and clinical outcomes in patients with chronic heart failure and following an acute coronary syndrome. The mechanism may relate to an effect on left ventricular (LV) remodeling. We hypothesized that β-adrenergic receptor polymorphisms predict LV remodeling after acute ST elevation myocardial infarction (STEMI). Methods: We assessed the presence of β-1 and β-2 adrenergic receptor polymorphisms in 122 patients after their first STEMI enrolled in a single-center randomized, double-blind placebo controlled trial of L-arginine vs. placebo, 91% of whom received successful early reperfusion therapy. All patients were treated with a beta-1 receptor antagonist and underwent baseline (mean 5.9 days following STEMI) and 6-month LV volume evaluation using gated blood pool imaging. Univariate and multivariate linear and logistic regressions were used to assess the relationships between the polymorphisms, β1 Arg389Gly, β1 Ser49Gly, β2 Gly16Arg and β2 Gly27Glu and the six-month changes in LV volumes. The top quintiles of LV end-systolic (ESV) and end-diastolic (EDV) 6-month volume increases and LV ejection fraction decrease were compared to the lower quintiles in the logistic regression analyses. Results: The polymorphisms β1 Arg389Gly, β1 Ser49Gly, β2 Gly16Arg were not associated LV remodeling. However, the 25% of patients homozygous for the β2 Glu27 variant were 5.2 times more likely to have an increase in 6-month ESV than those who had the Gln27 variant (OR 5.2, 95%CI 1.4 –19.0). Multiple linear regression analyses demonstrated that absolute ESV at six months was 19 ml greater (p = 0.02) and EDV was 21 ml greater (p = 0.01) in post STEMI patients with the β2 Glu27 polymorphism compared to the wild type or heterozygous patients. Conclusions: Increased LV volumes post-STEMI are associated with an increased risk of heart failure and death. The common β2 receptor polymorphism, Glu27Glu, is associated with increased odds of adverse LV remodeling in patients treated with a beta-one receptor antagonist. Whether treatment with a non-specific β-adrenergic receptor blocker guided by this genetic polymorphism ameliorates the effect requires further study.
Inherited Diatheses
Authors: C. O. Carter
Journal: BMJ (1967)

<h3>Abstract</h3> Tumor progression is dependent on metabolic reprogramming. Metastasis and vasculogenic mimicry (VM) are typical tumor progression. The relationship of metastasis, VM and metabolic reprogramming is not clear. In this study, we identified the novel role of Twist1, a VM regulator, in the transcriptional regulation of the expression of thymidine phosphorylase (TP). We demonstrated that TP promoted extracellular thymidine metabolization into ATP and amino acids through pentose Warburg effect by coupling the pentose phosphate pathway and glycolysis. Moreover, Twist1 relied on TP-induced metabolic reprogramming to promote hepatocellular carcinoma (HCC) metastasis and VM formation mediated by VE-Cad, VEGFR1, and VEGFR2 in vitro and in vivo. TP inhibitor tipiracil reduced promotion effect of TP enzyme activity on HCC VM formation and metastasis. Our findings demonstrate that TP, transcriptionally activated by Twist1, promotes HCC VM formation and metastasis through pentose Warburg effect, contributing to tumor progression.
PLATELET INFUSIONS
Journal: JAMA (1961)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Single-cell analysis of self-antigen-specific CD4 T cells reveals the B helper signature and the peripheral reservoir of autoreactive T cells in autoimmune hepatitis
Authors: Amédée Renand, Cervera-Marzal Iñaki, Gil Laurine, Dong Chuang, Kervagoret Erwan, Hélène Aublé, Sarah Habes, Cardon Anaïs, Jean-Paul Judor, Jean-François Mosnier, Sophie Brouard, Jérôme Gournay, Pierre Milpied, Sophie Conchon
Journal: Journal of Hepatology (2020)
Placebo in Clinical Trials for Depression: Complexity and Necessity—Correction
Authors: Amy Howell, Betsy Foxman
Journal: JAMA (2002)

lates and 19 (79%) of the 24 antibiotic-resistant isolates in all bioassays, while preconsumption urine (average pH 6.2) failed to prevent adhesion in any of the samples.Antiadhesion activity was evident in the urine within 2 hours and persisted for up to 10 hours following cranberry juice cocktail ingestion.The extracted proanthocyanidins inhibited adhesion of all isolates at concentrations ranging from 6 to 375 µg/mL, demonstrating potent in vitro antiadhesion activity against these antibioticresistant strains.Conclusions.These data suggest that consumption of cranberry juice cocktail may offer protection against both sensitive and resistant strains of P-fimbriated E coli by a mechanism that is not likely to increase selective pressures associated with antibiotic resistance.In light of the evidence that antibiotic usage is a contributing factor in development of trimethoprim-sulfamethoxazole-resistant uropathogenic E coli, 5 further trials are warranted to explore the use of cranberry juice as an alternative strategy to prevent UTIs and potentially reduce the rate of antibiotic resistance.
Pelvic Lipomatosis
Authors: Roberta C. Locko
Journal: JAMA (1980)

PELVIC lipomatosis is a term used by Fogg and Smyth<sup>1</sup>in 1968 to describe the "overgrowth of normal fatty tissue, limited to the perirectal and perivesical spaces in the pelvis." This entity initially was reported by Engles in the five cases with radiolucent changes surrounding the pelvic viscera.<sup>2</sup>Since that time, approximately 60 cases have been reported. Its clinical and roentgenographic findings are well established, as are the major complications of infection and urinary tract obstruction. The association of pelvic lipomatosis and inferior vena caval obstruction has been made by Schechter in a single case report.<sup>3</sup>Further review of the literature yielded the report of congenital venous anomalies associated with pelvic lipomatosis.<sup>4</sup>To our knowledge, ours is the second report of pelvic lipomatosis as a primary disease entity with a resultant vena caval obstruction. <h3>Report of a Case</h3> A previously healthy 30-year-old man was admitted to The
"Not" Omitted
Journal: JAMA (1976)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Anxiety during MRI
Authors: S. A. Persili
Journal: JAMA (1994)

<h3>To the Editor.</h3> —The article by Mr Mélendez and Dr McCrank<sup>1</sup>provides an excellent review of anxiety-related reactions associated with magnetic resonance imaging (MRI) examinations. However, missing from their review were some relevant articles<sup>2-4</sup>that we came across in preparing our own ongoing study on anxiety-induced artifacts in MRI. Two of these studies<sup>2,3</sup>were probably not known to the authors because they were published in European journals: one in German and the other in Italian (both, however, have English abstracts). We would especially like to draw your readers' attention to the study by Oberstein et al.<sup>2</sup>With 21 633 subjects, it is by far the largest study so far published in this field. The results of this detailed study reveal two main obstacles that reduce the value of MRI routine examinations. First, an impaired tolerance to the investigation occurred in an average of 12% of cases
A STUDY OF EIGHTEEN CONSECUTIVE CASES OF WHOOPING COUGH TREATED BY THE ELASTIC ABDOMINAL BELT.
Authors: THERON WENDELL KILMER
Journal: JAMA (1904)

The article with the above title appeared inThe Journal, Dec. 10, 1904, page 1749, without Figures 1 and 2. This omission was due to an oversight and these two illustrations of the belt as applied in whooping cough are shown here. The method of application was described in the article. <h3>Sanatoria in Germany.</h3> —The annual meeting of those officially interested in the sanatorium movement in Germany was held at Berlin, May 20, in the main hall of the parliament buildings. It was announced that there are at present 69 sanatoria, with 5,800 beds, for working people insured against sickness. In addition, there are 25 private sanatoria which receive these patients. Nine more are in process of construction and a number are projected. To date, 30 millions of marks, or about $7,500,000, have been spent for sanatoria for pulmonary affections. The central committee has spent about $300,000 for the same purpose. It was proclaimed that
Noncholesterol sterols in bile and stones of patients with cholesterol and pigment stones
Authors: T Miettinen
Journal: Hepatology (1996)

Human bile and cholesterol gallstones contain sterols including methylated (lanosterol and other dimethyl and monomethyl sterols), and demethylated cholesterol precursor sterols (Δ 8-lathosterol, lathosterol, and desmosterol), plant sterols (campesterol and sitosterol), and cholestanol. The aim of the study was to analyze the noncholesterol sterols in gallbladder bile and stones from female and male patients with cholesterol stones (CS) and pigment stones (PS) to ascertain whether any sterol fraction contributes to the gallstone formation. Classification of gallstones to CS and PS was performed on the basis of the stone cholesterol content. The study group consisted of 165 consecutive cholecystectomized patients, 150 with CS and 15 with PS. Bile acids and sterols were quantitated using gas-liquid chromatography (GLC). The biliary lipid and noncholesterol sterol/cholesterol proportions were similar in the CS and PS patients. The proportions of methylated and plant sterols were significantly lower in the CS than in bile, whereas those of Δ 8-lathosterol, lathosterol, and cholestanol were significantly higher. The PS, in contrast to the CS, were neither sex nor weight related. The bile acid and phospholipid concentrations and the proportions of lanosterol, Δ 8, 24-dimethylsterol, and sitosterol were up to 50 times higher and those of Δ 8-lathosterol and lathosterol twice lower in the PS than in the CS. The results suggest that, in general, the stones with low cholesterol content are proportionately richer in nonpolar precursor and plant sterols and lower in demethylated precursors, the situation being opposite for the CS. The stone/bile ratios suggest that in both stone groups, but especially in the CS, levels of the polar precursor sterols and cholestanol were enriched in the stone, whereas levels of the nonpolar precursor sterols, and to a lesser extent plant sterols, were not enriched in the stone despite their high biliary proportions.
Current Hematology
Authors: Robert B. Scott
Journal: JAMA (1982)

The first volume of<i>Current Hematology</i>, another compilation of reviews to add to those already weighing heavily on the shelves of most medical libraries, arrives with the editor's hope that it will be different. One can readily agree with Fairbanks' observation that the publication explosion in biologic science makes "keeping up" impossible, even in relatively narrow specialties. Many would also add that a proliferation of reviews, seminars, and clinics in hematology have not produced a medium that broadly covers major areas of hematology on a regular basis. Too often they serve the author's specialized interest or review an area of research of most value to the investigators. This new publication presumes to fill a need for a broad representation of the literature in major topics in hematology. No attempt is made to be all-inclusive in this first volume, and the potential clinical relevance of each subject is emphasized, though the
Pembrolizumab versus brentuximab vedotin in relapsed or refractory classical Hodgkin lymphoma (cHL): randomized phase 3 KEYNOTE-204 study
Authors: M.A. Fanale, J. Kline, R. Chen, V. Ribrag, G. Salles, I. Matsumura, Y. Zhu, A.D. Ricart, A. Balakumaran, P.L. Zinzani
Journal: Annals of Oncology (2016)
Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome
Authors: Guillermina Girardi, Jessica Berman, Patricia Redecha, Lynn Spruce, Joshua M. Thurman, Damian Kraus, Travis J. Hollmann, Paolo Casali, Michael C. Caroll, Rick A. Wetsel, John D. Lambris, V. Michael Holers, Jane E. Salmon
Journal: Journal of Clinical Investigation (2004)
Peripheral nerve block with phenol in the management of spasticity. Indications and complications
Authors: A. A. Khalili
Journal: JAMA (1967)

After accurate isolation, 126 peripheral nerves were blocked with 2% or 3% phenol solutions in distilled water in 68 patients with severe spasticity of various causes. Seven nerve blocks were repeated. The period of effectiveness ranged from 2 to 743 days, with an average of 308 days. Paresthesia occurred following ten nerve blocks. Gain and loss of voluntary movement following the blocks were observed. Ease, simplicity, safety, therapeutic benefits, and economic advantages of peripheral nerve block with phenol warrant its more widespread use.