tbuckley/cabot-search huggingface dataset:
Pentamidine-associated fatal acute pancreatitis
Authors: A. Zuger
Journal: JAMA (1986)

Severe hemorrhagic pancreatitis developed in a patient with the acquired immunodeficiency syndrome (AIDS) during pentamidine isethionate treatment for<i>Pneumocystis carinii</i>pneumonia. Despite prompt withdrawal of administration of the drug, the patient died of complications of pancreatitis. Pentamidine is known to be toxic to pancreatic islet cells, causing both hypoglycemia and hyperglycemia in clinical use. However, it rarely causes symptomatic pancreatitis. A review of the literature indicates that this is the second report of fatal pancreatitis associated with pentamidine therapy. (<i>JAMA</i>1986;256:2383-2385)
Books Received.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Chiropractors' Certificates Refused.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
RIO DE JANEIRO
Journal: JAMA (1929)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
On the Medical Services of the Navy and Army from the Accession of Henry VIII to the Restoration
Authors: W. R. E. Smart
Journal: BMJ (1874)

In conclusion, I will only add the expression of my deliberate belief, that the close attention now given to sanitary matters by our medical officers of health and others cannot fail, before long, to effect a con- siderable diminution in the prevalence of certain kinds of parasites and their associated parasitic diseases.
A comprehensive approach to evaluating and classifying sun-protective clothing
Authors: N.J. Downs, S.L. Harrison
Journal: British Journal of Dermatology (2018)

Summary Excessive exposure to sunlight causes skin cancer, the most common cancer in humans. An estimated 80% of melanoma (the most deadly form of skin cancer) cases in Australia could be prevented by reducing sun exposure. Clothing provides a protective barrier that reduces the amount of solar ultraviolet radiation (UVR) reaching the skin. In 1996, Australia pioneered a relative ranking of the sun-protective capabilities of clothing based on the transmission of UVR through fabric, known as the Ultraviolet Protection Factor (UPF). UPF garment swing tags were introduced as part of this original standard (AS/NZS 4399:1996) which was widely adopted by industry. However, it did not consider the body surface area (BSA) covered by garments. Minimum body coverage requirements for the torso and limbs were added to some standards (e.g. European Union, 2003; Australian/New Zealand, 2017) but not others (e.g. USA). In light of recent evidence showing that clothing coverage is important in preventing some of the pigmented moles that develop in childhood (important risk-factor for melanoma), it is imperative that sun-protective clothing rating schemes consider BSA coverage of the garment, in addition to fabric UPF. We developed a new index for rating sun-protective clothing, “the Garment Protection Factor (GPF)” that incorporates both of these important factors. BSA coverage is determined based on the number of lines visible on a clothed versus an unclothed mannequin. GPF increases with BSA coverage of the garment and fabric UPF over 3 categories: GPF 0 to &amp;lt; 3 indicates the garments ‘meets’ minimum standards; 3 to &amp;lt; 6 indicates ‘good’ sun-protection; and GPF ≥ 6 indicates ‘excellent’ protection. Adoption of this rating scheme should provide an incentive for manufacturers to design sun-protective garments that exceed the minimum standard for BSA coverage and fabric UPF, and provide consumers with adequate information on which to base their choice, with positive implications for skin cancer prevention.
THE EFFECTS OF CONTINUED ADMINISTRATION OF IODIDE
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Role of cytoskeleton and acidification of endocytic compartment in asialoglycoprotein metabolism in isolated rat hepatocyte couplets
Authors: M HARADA
Journal: Hepatology (1995)

The process of receptor-mediated endocytosis is common to a variety of species and cell types. One of the best characterized receptor-ligand systems is the hepatocyte receptor for asialoglycoproteins. We investigated the morphological features of the uptake and intracellular transport of gold-conjugated asialofetuin in isolated rat hepatocyte couplets. We assessed the effects of colchicine, lumicolchicine, cytochalasin B, and chloroquine on the uptake and intracellular transport of asialoglycoproteins. Isolated rat hepatocyte couplets were incubated with gold-conjugated asialofetuin, and transmission electron micrographs of these cells were analyzed to determine the density and distribution of gold particles in the peripheral and pericanalicular areas. Results were analyzed morphometrically. Colchicine significantly inhibited the uptake and intracellular transport of asialoglycoproteins, but did not affect membrane fusion of endocytic compartments in the peripheral area. Lumicolchicine and cytochalasin B had minimal effects on these processes. Chloroquine inhibited the uptake of asialoglycoproteins, but did not affect the intracellular transport of asialoglycoproteins. Results suggest that the microtubule is essential for intracellular movement of endocytosed asialoglycoproteins and receptor recycling, and that endocytic structures in the peripheral regions can fuse in the absence of intact microtubules. We also found that uptake and intracellular transport of asialoglycoproteins were independent of the microfilaments, and the pH gradient in endocytic compartments was important in receptor-mediated endocytosis of asialoglycoproteins.
Prevention of Posttransfusion Hepatitis by γ- Globulin
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SOCIETY NEWS.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Scientific Exhibit
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The physician, the media, and the 'spectacular' case
Authors: W. C. DeVries
Journal: JAMA (1988)

THE PRESS came into the operating theater 20 years ago when Christiaan Barnard, MD, electrified the world by performing the first human heart transplant. Since then, physicians with a "spectacular" medical case have found themselves, their patients, and their projects in the unwavering spotlight of the press. In our media-intrusive society, the spectacular case confronts physician-researchers with dilemmas unknown to their professional forebears. If the research happens to be conducted in the United States, the problems—or opportunities—tend to be intensified. American press organizations are unique in that their freedom to report news is guaranteed by the national constitution, and freedom and protection from previous restraint cannot be limited by government. Legislation and judicial decisions during the past quarter century have tended to make reporters' access to information easier, and citizens' recourse in libel actions more difficult. Consider these factors in relation to a spectacular, newsworthy medical case, especially one where
Sudden Blindness
Authors: J. Minton
Journal: BMJ (1939)

following the introduction of the immunization, while eight cases with two deaths were recorded among the small proportion of non-inoculated workers (Grasset, Lewin, and van der Merwe, 1937).With a view to the possibility of reinforcing the im- munity so produced investigations were undertaken with an alum-precipitated endotoxoid prepared on lines similar to the principle elaborated by Glenny for diphtheria immunization.Such precipitated endotoxoid confers upon mice a protection against Vi B. typhosus at least as strong as that conferred by unmodified endo- toxoid; in man, without causing undue reaction, it is followed by an agglutinin formation to titres such as 1/800 of H and 1/200 of 0 during the month following the inoculation.Recent investigations on the nature of typhoid endo- toxoid carried out in collaboration with H. D. Barnes- to be incorporated in a separate publication-have shown that by means of alcoholic precipitation a purified anti- gen is obtained.On being redissolved in saline the precipitated material confers on the mice and rabbits a degree of immunity and an agglutinin titre equal to that afforded by the untreated endotoxoid.These results are in agreement with those obtained by Topley, and Boivin in France, with the lipide-polysaccharide complex, isolated by various methods from the B. typhosus.Im- munization of man has been undertaken with this purified endotoxoid, and this procedure also results in the forma- tion of H and 0 agglutinins to considerable titre.With regard to the duration of the immunity produced by endotoxoid, serological investigations show that a very appreciable H and 0 agglutinin titre is still present at the end of the first year in the blood of the persons inoculated.Epidemiological data indicate that there is present in the second year a degree of protection practically equivalent to that observed during the first year.The introduction of typhoid endotoxoid is too recent for an actual limit of protection to be fixed.That in- formation can only be accumulated over a period of years by epidemiological data and by a close study of the greatest possible number of subjects who have been immunized by this new form of vaccine.
Ankylosing Spondylitis
Authors: DUNCAN A. GORDON
Journal: Annals of Internal Medicine (1973)

Comments and Corrections1 July 1973Ankylosing SpondylitisDUNCAN A. GORDON, M.D., M. LYNN RUSSELL, M.D., METRO A. OGRYZLO, M.D., ROBERT S. MCPHEDRAN, M.D.DUNCAN A. GORDON, M.D.Search for more papers by this author, M. LYNN RUSSELL, M.D.Search for more papers by this author, METRO A. OGRYZLO, M.D.Search for more papers by this author, ROBERT S. MCPHEDRAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-79-1-139_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The case report of Gordon and Yudell in the April 1973 issue (pp. 555-557) describing a "Cauda Equina Lesion Associated with Rheumatoid Spondylitis" raises the intriguing possibility that cerebrospinal fluid protein may be elevated when cauda equina symptoms are of short duration. Our three cases reported in the same issue (pp. 551-554) had normal levels of cerebrospinal fluid protein and neurological symptoms for 3, 8, and 15 years, respectively.In their case the myelogram was reported as normal, but it was not stated whether it was done in the supine position. Although some difficulty was encountered in... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Toronto Rheumatic Disease Unit The Wellesley Hospital Toronto Canada PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAdded Value of Anti-CD74 Autoantibodies in Axial SpondyloArthritis in a Population With Low HLA-B27 PrevalenceAnkylosing Spondylitis: Early Diagnosis Based on the Natural History 1 July 1973Volume 79, Issue 1Page: 139-140KeywordsAnkylosing spondylitisCerebrospinal fluidLesionsProteins Issue Published: 1 July 1973 PDF DownloadLoading ...
Biotin deficiency in an adult during home parenteral nutrition
Authors: C. J. McClain
Journal: JAMA (1982)

BIOTIN deficiency in man has been extremely rare, presumably because this vitamin is ubiquitous in the diet and is also produced by the gut flora. Raw egg white contains a protein, avidin, which tightly binds biotin and renders it poorly absorbed. In 1942 Sydenstricker et al<sup>1</sup>induced biotin deficiency in adult volunteers by feeding them a diet to which 200 g of dehydrated egg white had been added. Symptoms of biotin deficiency were produced that reversed with daily injections of 75 to 300 μg of biotin. More recent reports have described infants with inborn errors in the metabolism of biotin-dependent enzymes and signs and symptoms of biotin deficiency.<sup>2,3</sup>One child with short-bowel syndrome has been described in which signs of biotin deficiency appeared in association with parenteral nutrition and antibiotic therapy, and these signs reversed with administration of 10 mg of biotin a day.<sup>4</sup>These investigators presumed this
Quantitative assessment of ventricular volume, mass, and flow with cardiac magnetic resonance imaging in adults with repaired tetralogy of fallot. Relationship with electrocardiographic predictors of sustained ventricular tachycardia and sudden death Periklis A. Davlouros, Phillip Kilner, Tim S. Hornung, Jane Francis, Michael A. Gatzoulis. Royal Brompton Hospital, London, United Kingdom
Journal: Journal of the American College of Cardiology (2001)
Virological and biochemical long-term follow-up of patients with chronic hepatitis C treated with interferon
Authors: I Castillo
Journal: Hepatology (1994)

We studied the long-term outcomes of 43 patients with chronic hepatitis C treated with one or two interferon cycles, in relation to hepatitis C virus RNA in serum and peripheral-blood mononuclear cells. After the first interferon cycle, 15 (35%) patients had normal transaminase levels, although only five of them had normal levels throughout follow-up (complete responders). After treatment, hepatitis C virus RNA was detected in serum and peripheral-blood mono-nuclear cells with a similar frequency among the five complete responders (60% and 40%, respectively) and the 10 responders with relapse (50% and 20%, respectively). During the follow-up of the complete responders (up to 27 mo), fluctuating viremia levels were found, as demonstrated by the intermittent serum hepatitis C virus RNA positivity. In responders with relapse serum hepatitis C virus RNA reappeared concurrent with the relapse, without changes in peripheral-blood mononuclear cells. A second interferon cycle was performed in 23 nonresponders. Six of them had normalized transaminase levels but four had relapses. After retreatment, hepatitis C virus RNA was detected in peripheral-blood mononuclear cells with the same frequency (50%) in complete responders and in responders with relapse. Loss of serum hepatitis C virus RNA was only achieved in responders with relapse. During the follow-up, half of the complete responders lost serum hepatitis C virus RNA. This marker reappeared in responders with relapse, and hepatitis C virus RNA was found de novo in PBMCs of one responder with relapse. None of the 17 nonresponders to retreatment lost hepatitis C virus RNA in serum or PBMCs during therapy. In the follow-up, serum hepatitis C virus RNA became undetectable in four patients (one of them had normalized transaminase values), whereas viral RNA in peripheral-blood mononuclear cells was detected de novo in seven patients. In summary, hepatitis C virus RNA status in serum or peripheral-blood mononuclear cells after interferon treatment is unrelated to the long-term outcome of the patients. (HEPATOLOGY 1994;19:1342–1346.)