Statin-Associated Myopathy with Normal Creatine Kinase Levels
Authors: Paul S. Phillips, Richard H. Haas
Journal: Annals of Internal Medicine (2003)

Letters17 June 2003Statin-Associated Myopathy with Normal Creatine Kinase LevelsPaul S. Phillips, MD and Richard H. Haas, MDPaul S. Phillips, MDScripps Mercy Hospital; San Diego, CA 92103 (Phillips)University of California, San Diego; La Jolla, CA 92093-0935 (Haas)Search for more papers by this author and Richard H. Haas, MDScripps Mercy Hospital; San Diego, CA 92103 (Phillips)University of California, San Diego; La Jolla, CA 92093-0935 (Haas)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-138-12-200306170-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Dr. Hyman asks whether other biochemical markers might identify patients with statin-induced myopathy. Levels of aldolase and myoglobin, which would be released by disrupted myocyte membranes, have been normal whenever we have tested them in our patients. We are currently testing other indicators of the metabolic defect associated with this muscle toxicity (1).Drs. Torgovnick and Arsura inquire about the relation of this toxicity to exercise. Postexercise creatine kinase level is more sensitive than resting creatine kinase level in assessing muscle toxicity. The latter is related to membrane disruption but has not met with much success in assessing ...References1. Phillips P, Haas R, Barshop B, Bannykh S, Amjadi D. Utility of abnormal 3-methylglutaconic aciduria (3MGA) in diagnosing statin associated myopathy. Atheroscler Thromb Vasc Biol Online Journal. 2002; 22:878. Accessed at aha.agora.com/abstractviewer/av_view.asp. Google Scholar2. Reust CS, Curry SC, Guidry JR. Lovastatin use and muscle damage in healthy volunteers undergoing eccentric muscle exercise. West J Med. 1991;154:198-200. [PMID: 2006566] MedlineGoogle Scholar3. Smit JW, Bar PR, Geerdink RA, Erkelens DW. Heterozygous familial hypercholesterolaemia is associated with pathological exercise-induced leakage of muscle proteins, which is not aggravated by simvastatin therapy. Eur J Clin Invest. 1995;25:79-84. [PMID: 7737266] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Scripps Mercy Hospital; San Diego, CA 92103 (Phillips)University of California, San Diego; La Jolla, CA 92093-0935 (Haas) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoStatin-Associated Myopathy with Normal Creatine Kinase Levels Paul S. Phillips , Richard H. Haas , Sergei Bannykh , Stephanie Hathaway , Nancy L. Gray , Bruce J. Kimura , Georgirene D. Vladutiu , John D.F. England , and Statin-Associated Myopathy with Normal Creatine Kinase Levels Mark H. Hyman Statin-Associated Myopathy with Normal Creatine Kinase Levels Josh Torgovnick and Edward Arsura Statin-Associated Myopathy with Normal Creatine Kinase Levels Emil Toma and Maude Loignon Statin-Associated Myopathy with Normal Creatine Kinase Levels Louis Evan Teichholz Metrics Cited byTranslational insight into statin-induced muscle toxicity: from cell culture to clinical studiesStatin-induced myopathy: a review and update 17 June 2003Volume 138, Issue 12Page: 1008-1009KeywordsCoenzymesCreatine kinaseExerciseMuscle biopsiesMuscle cellsMuscle functionsMusclesRhabdomyolysisStatinsToxicity ePublished: 17 June 2003 Issue Published: 17 June 2003 Copyright & PermissionsCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...