tbuckley/cabot-search huggingface dataset:
Quality of life and psychological distress in patients with acute myeloid leukemia (AML).
Authors: Julia Carp, Lauren Waldman, Showly Nicholson, Lara Traeger, Gregory A. Abel, Joseph Greer, Amir Tahmasb Fathi, David P. Steensma, Thomas William LeBlanc, Daniel J. DeAngelo, Martha Wadleigh, Gabriela Hobbs, Andrew Mark Brunner, Philip C. Amrein, Richard M. Stone, Jennifer S. Temel, Areej El-Jawahri
Journal: Journal of Clinical Oncology (2018)

7035 Background: Older patients with AML face difficult treatment decisions as they can be treated either with multi-drug ‘intensive’ chemotherapy requiring a prolonged hospitalization, or ‘non-intensive’ chemotherapy. Although clinicians often perceive intensive chemotherapy as more burdensome, studies comparing older patients’ quality of life (QOL) and psychological distress while receiving these treatments are lacking. Methods: We conducted a longitudinal study of older patients (≥ 60 years) newly diagnosed with AML receiving intensive (i.e. 7+3: cytarabine/anthracycline combination) or non-intensive (i.e. hypomethylating agents) chemotherapy at two tertiary care hospitals. We assessed patient’s QOL [Functional Assessment of Cancer Therapy-Leukemia], and psychological distress [Hospital Anxiety and Depression Scale [HADS]] at baseline and 2, 4, 8, 12, and 24 weeks after diagnosis. We compared the proportion of patients in each group reporting clinically significant depression or anxiety (HADS subscale cut off ≥ 7) and used mixed linear effects models to compare QOL and psychological distress longitudinally between groups. Results: We enrolled 75.2% (100/133) of eligible patients within 72 hours of initiating intensive (n = 50) or non-intensive (n = 50) chemotherapy. Baseline QOL, depression, or anxiety symptoms did not differ between the groups. At baseline, 33.33% (33/100) and 30% (30/100) of the overall cohort reported clinically significant depression and anxiety, respectively, with no differences between groups. At 4 weeks, 41.98% (34/81) of patients in the overall cohort reported clinically significant depression, with no differences between groups. In mixed linear effects models, there were no differences in QOL (β = -0.71, SE = 1.12, P = 0.527), depression (β = 0.24, SE = 0.20, P = 0.226), or anxiety (β = -0.16, SE = 0.19, P = 0.386) symptoms over all time points. Conclusions: Older patients with AML receiving intensive and non-intensive chemotherapy experience similar QOL and high rates of psychological distress. These findings underscore the need to develop supportive care interventions for older patients with AML, regardless of their initial treatment strategy.
Abstract A46: Tpl-2 kinase downregulates the activity of p53 and enhances signaling pathways leading to activation of activator protein 1 induced by EGF
Authors: Hae-Gook Cho, Gwang Mo Namgoog, Hong Seok Choi
Journal: Cancer Research (2009)

Abstract Tumor progression locus-2 (Tpl-2) kinase is a member of the mitogen-activated protein kinase (MAPK) kinase kinase family that has been implicated in cellular transformation. The enhanced expression of this protein has been shown to activate both the MAPK and c-Jun N-terminal kinase (JNK) pathways. However the molecular mechanisms responsible for the oncogenic potential of Tpl-2 are still largely unknown. Here, we show that Tpl-2 interacts with p53 both in vitro and ex vivo. The overexpression of Tpl-2 inhibits the phosphorylation of p53 at serine 15 induced by EGF by upregulating the activity of protein phosphatase 2A (PP2A). In addition, the EGF-induced p53 activity was suppressed in the Tpl-2-wild-type-transfeted HEK 293 cells, but had no effect in the Tpl-2-mutant (S413A)-transfected cells. Furthermore, the Tpl-2 wild type, but not Tpl-2 mutant (S413A), showed increased EGF-induced c-fos promoter activity, followed by AP-1 transactivation activity, which is associated with the cell transformation prompted by the H-Ras-Tpl-2-AP-1 signaling axis. These results suggest that Tpl-2 plays an important role in EGF-induced carcinogenesis by inactivating the p53 tumor suppressor. Citation Information: Cancer Res 2009;69(23 Suppl):A46.
Society for Immunotherapy of Cancer clinical and biomarkers data sharing resource document: Volume II—practical challenges
Authors: Alessandra Cesano, Michael A Cannarile, Sacha Gnjatic, Bruno Gomes, Justin Guinney, Vaios Karanikas, Mohan Karkada, John M Kirkwood, Beatrix Kotlan, Giuseppe V Masucci, Els Meeusen, Anne Monette, Aung Naing, Vésteinn Thorsson, Nicholas Tschernia, Ena Wang, Daniel K Wells, Timothy L Wyant, Sergio Rutella
Journal: Journal for ImmunoTherapy of Cancer (2020)

The development of strongly predictive validated biomarkers is essential for the field of immuno-oncology (IO) to advance. The highly complex, multifactorial data sets required to develop these biomarkers necessitate effective, responsible data-sharing efforts in order to maximize the scientific knowledge and utility gained from their collection. While the sharing of clinical- and safety-related trial data has already been streamlined to a large extent, the sharing of biomarker-aimed clinical trial derived data and data sets has been met with a number of hurdles that have impaired the progression of biomarkers from hypothesis to clinical use. These hurdles include technical challenges associated with the infrastructure, technology, workforce, and sustainability required for clinical biomarker data sharing. To provide guidance and assist in the navigation of these challenges, the Society for Immunotherapy of Cancer (SITC) Biomarkers Committee convened to outline the challenges that researchers currently face, both at the conceptual level (Volume I) and at the technical level (Volume II). The committee also suggests possible solutions to these problems in the form of professional standards and harmonized requirements for data sharing, assisting in continued progress toward effective, clinically relevant biomarkers in the IO setting.
Association of Blood Arsenic Levels with Increased Reactive Oxidants and Decreased Antioxidant Capacity in a Human Population of Northeastern Taiwan
Authors: Meei-Maan Wu, Hung-Yi Chiou, Tsung-Wei Wang, Yu-Mei Hsueh, Iuan-Horng Wang, Chien-Jen Chen, Te-Chang Lee
Journal: Environmental Health Perspectives (2001)

Arsenic is a notorious environmental toxicant known as both a carcinogen and an atherogen in human beings, but the pathogenic mechanisms are not completely understood. In cell culture studies, trivalent arsenic enhanced oxidative stress in a variety of mammalian cells, and this association may be closely associated with the development of arsenic-related diseases. To investigate the effect of arsenic exposure on oxidative stress in humans, we conducted a population study to determine the relationships of blood arsenic to reactive oxidants and antioxidant capacity at the individual level. We recruited 64 study subjects ages 42-75 years from residents of the Lanyang Basin on the northeast coast of Taiwan, where arsenic content in well water varies from 0 to > or = 3,000 microg/L. We used a chemiluminescence method, with lucigenin as an amplifier for measuring superoxide, to measure the plasma level of reactive oxidants. We used the azino-diethyl-benzthiazoline sulphate method to determine the antioxidant capacity level in plasma of each study subject. We determined arsenic concentration in whole blood by hydride formation with an atomic absorption spectrophotometer. The average arsenic concentration in whole blood of study subjects was 9.60 +/- 9.96 microg/L (+/- SD) with a range from 0 to 46.50 microg/L. The level of arsenic concentration in whole blood of study subjects showed a positive association with the level of reactive oxidants in plasma (r = +0.41, p = 0.001) and an inverse relationship with the level of plasma antioxidant capacity (r = -0.30, p = 0.014). However, we found no significant association (p = 0.266) between levels of plasma reactive oxidants and antioxidant capacity. Our results also show that the lower the primary arsenic methylation capability, the lower the level of plasma antioxidant capacity (p = 0.029). These results suggest that ingestion of arsenic-contaminated well water may cause deleterious effects by increasing the level of reactive oxidants and decreasing the level of antioxidant capacity in plasma of individuals. Persistent oxidative stress in peripheral blood may be a mechanism underlying the carcinogenesis and atherosclerosis induced by long-term arsenic exposure.
WAR WOUNDS AND THE STEEL TUBULAR BULLET.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Environmental Illness
Authors: Alexander C. Chester, Foxhall Internists
Journal: JAMA (1991)

<h3>To the Editor.—</h3> Black et al<sup>1</sup>described a preponderance of psychiatric symptoms in 26 patients with environmental illness (EI) and propose that commonly recognized psychiatric disorders explain some or all of the symptoms. The triggering event for 50% of the patients was exposure to fumes at work or home, and the most common symptoms were respiratory and neurological problems (including headaches) and fatigue. An outbreak of similar symptoms occurred at a high school near Sacramento, Calif. Teachers reported the onset of recurrent upper respiratory tract infections and fatigue predominantly in the 11 men and 12 women (20% of the faculty) teaching in the "J" wing. With no functioning windows and malfunctioning fresh-air intake and exhaust dampers, the separate circulating hot air and air conditioning system maintained poor-quality ventilation. Air described as occasionally hazy and foul smelling was at least in part due to poorly maintained air filters and gasoline
Vocal cord paralysis after tracheal intubation
Authors: H. S. Holley
Journal: JAMA (1971)

In skilled hands, tracheal intubation during anesthesia is a relatively safe procedure. Nonetheless, laryngeal complications may occur after intubation, although they are usually transient and minor. Sore throat occurs about 40% of the time and usually lasts 48 to 72 hours.<sup>1</sup>Laryngitis has been reported after 3% of intubations and may last several days. Postintubation laryngeal edema occurs rarely in adults, but can be a distressing complication in infants and young children. Occasionally, membrane formation and laryngeal ulceration have been reported. Lesions on the vocal cords seem to be rare, but granulomas or ulcerations have been reported, particularly after prolonged tracheal intubation. A few cases of vocal cord paralysis following endotracheal anesthesia have been reported.<sup>2-4</sup>The following four case reports illustrate this complication. <h3>Report of Cases</h3><h3>Case 1.—</h3> A 64-year-old man entered the hospital with a history of worsening intermittent claudication of the left leg. He was admitted
Abstract P289: Sex Differences in the Rate of Visceral Adipose Tissue Accrual During Adulthood
Authors: Kara M Whitaker, Audrey C Choh, Miryoung Lee, Stefan A Czerwinski, Ellen W Demerath
Journal: Circulation (2016)

Introduction: Excess visceral adipose tissue (VAT) robustly predicts incident cardiometabolic risk, independent of body mass index (BMI), and this association is stronger in women than in men. Cross-sectional studies suggest that VAT accrual accelerates in older women as compared to similarly aged men, in concert with menopausal changes, which may help to explain the greater effect of VAT on subsequent disease risk observed in women. However, a direct test of sex differences in the rate of VAT accrual requires longitudinal VAT data which have been largely lacking. Objectives: This analysis evaluated sex differences in the rate of VAT accrual in adults. Secondary analyses examined differences in the rate of VAT accrual in pre-, peri-, and post-menopausal women. Methods: Participants were 532 (59% female) non-Hispanic white adults, aged 18-84 years at baseline, who were enrolled in a study of normative changes in body composition over the lifespan. Abdominal VAT mass and subcutaneous adipose tissue (SAT) mass were assessed using multiple-image magnetic resonance imaging at two time points, with an average follow-up of 7.2 ± 2.5 years. Linear regression models were used to examine the effects of sex, baseline age, and their interaction on rate of change per year in body composition measures (ΔBMI, ΔVAT, and ΔVAT/SAT ratio (ΔVSR)) independent of baseline body composition measures and baseline visit year. Secondary analyses examined differences in these rates of change by baseline menopausal status (pre, peri, post), after adjustment for baseline age. Results: Levels of BMI, VAT, and VSR all increased over the follow-up period on average; however, the change in BMI (mean ΔBMI = +0.5%) was far smaller than for VAT (mean ΔVAT=+6.3%) and VSR (mean ΔVSR = +3.4%). ΔVAT and ΔBMI decreased linearly with age in both sexes (p&lt;0.001), such that older individuals had lower rates of VAT and BMI gain, and this deceleration in VAT and BMI accrual was greater in men than women (p for interaction 0.007 and 0.038, respectively). ΔVSR did not vary with age in either sex, but remained higher in men than women throughout adulthood. ΔBMI, ΔVAT, and ΔVSR did not differ by baseline menopausal status. Conclusions: VAT mass increased with age in both men and women, but the rate of VAT gain gradually declined with advancing age. There was no evidence of accelerated VAT accrual during menopause as previously reported in the literature. However, the rate of VAT gain was more consistent in women during adulthood than in men, who exhibited greater deceleration. Future work will explore whether this sex difference in the pattern of body composition change explains the differential effects of VAT on disease risk in men and women.
Decreased selenium levels in acute myocardial infarction
Authors: F. J. Kok
Journal: JAMA (1989)

To study the association between selenium status and the risk of myocardial infarction, we compared plasma, erythrocyte, and toenail selenium levels and the activity of erythrocyte glutathione peroxidase among 84 patients with acute myocardial infarction and 84 population controls. Mean concentrations of all selenium measurements were lower in cases than controls. The differences were statistically significant, except for the plasma selenium level. A positive trend in the risk of acute myocardial infarction from high to low toenail selenium levels was observed, which persisted after adjustment for other risk factors for myocardial infarction. In contrast, erythrocyte glutathione peroxidase activity was significantly higher in cases than controls (31.3 ± 8.4 U/g of hemoglobin and 28.0 ±8.1 U/g of hemoglobin, respectively). Because the toenail selenium level reflects blood levels up to one year before sampling, these findings suggest that a low selenium status was present before the infarction and, thus, may be of etiologic relevance. The higher glutathione peroxidase activity in the cases may be interpreted as a defense against increased oxidant stress either preceding or following the acute event. (<i>JAMA</i>1989;261:1161-1164)
Operative Surgery: Principles and Techniques
Authors: Ben Eiseman
Journal: JAMA (1980)

For eight years, Nora's<i>Operative Surgery</i>has been the security blanket of the junior surgery resident. It contains just enough material on preoperative and postoperative care to cover most of what the young surgeon wants to know and describes explicitly how to perform most classic general surgical procedures. Now Nora has brought his book up to date in a second edition. New techniques, such as stapling and vascular access for hemodialysis, have been added. Advances in pharmacology as they affect the surgeon—for example, histamine H-2 blockers—have been given their place. Most important, Nora has chosen good surgeons to add new chapters on procedures, eg, gastric operations for obesity, that have come into general use since his last edition. In other areas the new chapters reflect the current vogue, such as those deemphasizing radical surgery in favor of less extensive mastectomy for cancer. This book is designed for the general
Archives of Neurology, Chicago
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sixty-Sixth Annual Meeting of the American Radium Society
Journal: JNCI Journal of the National Cancer Institute (1983)

Journal Article Sixty-Sixth Annual Meeting of the American Radium Society Get access JNCI: Journal of the National Cancer Institute, Volume 71, Issue 4, October 1983, Page 877, https://doi.org/10.1093/jnci/71.4.877-b Published: 01 October 1983
THE PHILIPPINE INSULAR BOARD OF HEALTH.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Neurological Technique. Some Special Histological Methods Employed for the Study of the Nervous System, Together with a Laboratory Outline for the Dissection of the Central Nervous System and the Neurological Nomenclature (BNA) Arranged in a Classified List.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SURGERY.
Journal: JAMA (1884)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal