tbuckley/cabot-search huggingface dataset:
High Breast Milk Levels of Polychlorinated Biphenyls (PCBs) among Four Women Living Adjacent to a PCB-Contaminated Waste Site
Authors: Susan A. Korrick, Larisa Altshul
Journal: Environmental Health Perspectives (1998)

As a consequence of contamination by effluents from local electronics manufacturing facilities, the New Bedford Harbor and estuary in southeastern Massachusetts is among the sites in the United States that are considered the most highly contaminated by polychlorinated biphenyls (PCBs). Since 1993, measures of intrauterine PCB exposure have been obtained for a sample of New Bedford area infants. Among 122 mother-infant pairs, we identified four milk samples with total PCB levels that were significantly higher than the rest, with estimated total PCBs ranging from 1,100 to 2,400 ng/g milk fat compared with an overall mean of 320 ng/g milk fat for the 122 women. The congener profile and history of one case was consistent with past occupational PCB exposures. Otherwise, the source of PCB exposures in these cases was difficult to specify. Environmental exposures including those from fish consumption were likely, whereas residence adjacent to a PCB-contaminated site was considered an unlikely exposure source. In all four cases, the infants were full-term, healthy newborns. Because the developing nervous system is believed to be particularly susceptible to PCBs (for example, prenatal PCB exposures have been associated with prematurity, decrements in birth weight and gestation time, and behavioral and developmental deficits in later infancy and childhood, including decrements in IQ), it is critical to ascertain if breast-feeding is a health risk for the women's infants. Despite the potential for large postnatal PCB exposures via breast milk, there is limited evidence of significant developmental toxicity associated with the transmission of moderate PCB concentrations through breast milk. Breast-feeding is associated with substantial health benefits including better cognitive skills among breast-fed compared with formula-fed infants. We conclude, based on evidence from other studies, that the benefits of breast-feeding probably outweigh any risk from PCB exposures via breast milk among the four New Bedford infants. In this case report, PCB analysis of breast milk and infant cord serum was a research tool. PCB analysis of milk is rarely done clinically, in part because it is difficult to use the results of such analyses to predict health risks. Substantial effort is needed to achieve a better understanding of the clinical and public health significance of PCB exposures, particularly among potentially susceptible groups such as infants and children. Such efforts are critical to improving the clinical and public health management of widespread and ongoing population exposures to PCBs.
AASLD program
Authors: Thomas Starzl Transplant, Shuttle Buses, Clyde Barker, Adel Bozorgzadeh, Pradip Chakrabarti, Chao-Long Chen, David Cooper, Bijan Eghtesad, Ira Fox, John Fung, Ashokkumar Jain, Zakiyah Kadry, Dympna Kelly, Charles Miller, Ernesto Molmenti, Michael Morris, Eduardo Santiago-Delpin, Byers Shaw, Cynthia Smetanka, Lewis Teperman, Paul Terasaki, Gianfranco Alpini, Miriam Alter, Frank Anania, Paul Angulo, Laura Beretta, Nathan Bass, Alex Befeler, Edmund Bini, Andres Blei, Henry Bodenheimer, Maurizio Bonacini, James Boyer, Norbert Bräu, David Brenner
Journal: Hepatology (2006)

Provide a forum for exchange of groundbreaking basic and clinical research in liver diseases.• Create an arena
AMERICAN SOCIETY OF HEMATOLOGY Thirteenth Annual Meeting, 1970, Puerto Rico, December 5-9
Authors: Robert Weed, Samuel Rapaport, Ama Wmit, Dane Boggs, Daniel Bergsagel, John Ultmann, Gearge Chairmen, James Brecher, P Repeat, Frederick Klipstein, Robert Hillman, Richard Rosenfield, Herbert Perkins, Robert Lange
Journal: Blood (1970)
PUBLIC SANITARIA.
Authors: C. P. AMBLER
Journal: JAMA (1902)

The large number of alleged "cures" for tuberculosis which are constantly appearing as new remedies in the treatment of this disease, only go to prove that the medicinal treatment of tuberculosis, if depended upon empirically, is failing in the object to be attained. We have elsewhere (Columbus meeting of the American Medical Association) claimed that the hygienic treatment of this disease should occupy first place, in no matter what climate or under what conditions the patient was being treated; that climate should occupy second place, while medication in point of preference should be given third place. The consensus of opinion of all writers who deal largely with this disease now practically agree in this, the same proving that the hygienic care of the patient is of the greatest importance. The question immediately arises as to how we can place our patients under the best hygienic conditions. I understand that under
THE PARATHYROID HORMONE
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
DISTINCT CLINICOLABORATORY CHARACTERISTICS of the t(14;19)(q32;q13)-POSITIVE SPLENIC MARGINAL ZONE LYMPHOMA
Authors: Hunan Julhakyan, Aminat Magomedova, Sergey K Kravchenko, Tatyana N Obukhova, Rima Samoylova, Irina B Kaplanskaya
Journal: Blood (2011)
Highlights
Authors: Howard Bauchner, Gregory Curfman, Francis Alenghat, Gaurav Upadhyay
Journal: JAMA (2019)

Catheter Ablation vs Medication for Atrial Fibrillation 1059Catheter ablation is indicated for the control of symptoms in patients with atrial fi brillation, but previous comparisons of catheter ablation and antiarrhythmic medication have targeted changes in cardiac rhythm rather than symptomatic improvement.Blomström-Lundqvist and colleagues randomized 155 patients with symptomatic atrial fi brillation who had received treatment with a single antiarrhythmic medication and found that improvement in quality of life at 12 months was greater for patients treated with catheter ablation than for those who tried all available antiarrhythmic drugs.
Age-Dependent Response of the Rat Testes to Di(2-Ethylhexyl) Phthalate
Authors: Per Sjoberg, Nils Gunnar Lindqvist, Leif Ploen
Journal: Environmental Health Perspectives (1986)

Spermatogenesis starts soon after birth in the Sprague-Dawley rat but is not fully established until about 56 days of age.When high oral doses of the plasticizer di(2-ethylhexyl) phthalate (DEHP) were given to rats of different ages, testicular damage was observed in immature but not in mature animals.Plasma concen- tration and urinary excretion data suggested that the gastrointestinal absorption of the DEHP-derived metabolite mono(2-ethylhexyl) phthalate was higher in young animals.Young rats were not more susceptible than older for repeated intravenous infusions of DEHP.It is suggested that the age-related difference observed in testicular response after oral administration of DEHP may be due to pharmacokinetic rather than tissue sensitivity differences.It is concluded that in assessing risks of testicular injuries in children exposed to DEHP, additional studies are required using species in which testicular development is more similar to that of humans.
Scientists urged to hold firm to eye transplant goal
Journal: JAMA (1978)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Independent Domains of Inhibitory Gating in Schizophrenia and the Effect of Stimulus Interval
Authors: L. Hong
Journal: American Journal of Psychiatry (2007)

Objective: Patients with schizophrenia are known to have inhibitory gating deficits in the suppression of evoked potential P50 response to repeated stimuli and the prepulse inhibition of the startle response. In the current study, the authors aimed to determine whether these two inhibitory gating measures are related in schizophrenia patients or whether abnormal P50 suppression and abnormal prepulse inhibition are independent neurophysiological characteristics of schizophrenia. The authors hypothesized that the relationship of the two measures may vary as a function of interstimulus intervals of stimulus presentations. Method: Fifty-nine schizophrenia patients and 17 healthy comparison subjects were tested on both P50 suppression and prepulse inhibition. P50 suppression was measured using paired clicks with 500-msec interstimulus intervals. Prepulse inhibition was measured by using a series of prepulse-pulse pairs with interstimulus intervals ranging from 30 to 500 msec. Results: Patients showed reduced P50 suppression and prepulse inhibition in relation to healthy comparison subjects. Concordance analysis showed that abnormal P50 suppression and abnormal prepulse inhibition do not necessarily occur together. Prepulse inhibition was most prominent at the 120-msec interstimulus interval, which was not correlated to P50 suppression. At the 500-msec interstimulus interval, prepulse inhibition was significantly but negatively correlated to P50 suppression. Prepulse inhibition at the other interstimulus intervals was not correlated with P50 suppression. Conclusions: These neurophysiological measures lack robust and direct relationships and likely mark independent aspects of abnormal brain inhibitory functions in schizophrenia.
Maternal Serum α-Fetoprotein Monitoring
Journal: JAMA (1982)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nasogastric Intubation in Anesthetized Patient
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
POISONS PRODUCED BY BACTERIA.
Journal: JAMA (1890)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Studies of the Effect of Immunoglobulin on Rubella in Pregnancy
Journal: BMJ (1970)

Studies were done on 5,447 pregnant women given immunoglobulin after exposure to rubella and on 652 adult women similarly at risk but not pregnant and therefore not given immunoglobulin. The amounts of immunoglobulin, of known antibody content ranged from 750 mg. to more than 1,500 mg.; in a few second doses were given. Preinoculation blood samples from both groups showed that about 15% were still susceptible. Second blood samples were obtained from many of the women and nasal and throat swabs from as many index cases as possible. In the development of rubella by susceptible women a major factor was an index case in the same household. Whether judged on the serological evidence alone, or as a result of exposure to a confirmed index case, immunoglobulin in the amounts given did not appear to affect the incidence of rubella by comparison with the uninoculated group. Suppression of clinical manifestations attributable to immunoglobulin was possible in a few instances, but this could also have been an example of natural variation.
Issue Highlights
Journal: Circulation (2006)

Atrial fibrillation after cardiac surgery is associated with increased length of hospital stay and increased morbidity.Increasing evidence points to a role for inflammation in the pathogenesis of atrial fibrillation.In this issue of Circulation, Patti and colleagues evaluate the effect of atorvastatin on postoperative atrial fibrillation in a randomized, placebo-controlled trial of 200 patients undergoing cardiopulmonary bypass surgery.Atorvastatin begun preoperatively reduced atrial fibrillation and was associated with a small reduction in length of hospital stay.Benefit was seen in patients taking ␤-adrenergic blockers and was not influenced by age.No benefit was demonstrated for the small subgroup having valve surgery.The present study is unlikely to be repeated in patients with coronary disease, as most have an indication for therapy with a 3-hydroxy-3-methylglutaryl coenzyme reductase inhibitor.It should, however, foster further studies of the mechanism of benefit and should help to determine whether patients having valve surgery alone might benefit.See p 1455.
Missing Conflict of Interest Disclosures
Journal: JAMA Internal Medicine (2014)

Edward F. Patz Jr, MD; Paul Pinsky, PhD; Constantine Gatsonis, PhD; JoRean D. Sicks, MS; Barnett S. Kramer, MD, MPH; Martin C. Tammemägi, PhD; Caroline Chiles, MD; William C. Black, MD; Denise R. Aberle, MD; for the NLST Overdiagnosis Manuscript Writing Team
Notes on New Names
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
No evidence of an emerging physician surplus. An analysis of change in physicians' work load and income
Authors: W. B. Schwartz
Journal: JAMA (1990)

Analysis of physicians' work patterns and income between 1982 and 1987 provides strong evidence that the demand for physicians' services has risen at least as quickly as physician supply. Aggregate hours spent by US physicians who provide patient care rose by 21%, and aggregate real net income rose by more than 30% during a period in which the supply of physicians grew by only 16%. The aggregate number of visits rose by only 9%, indicating that the time spent per patient encounter rose sharply, presumably as a result of technological change and the increased complexity of care. Recently released data for 1988 are consistent with these trends. Our findings are inconsistent with the prediction by the Graduate Medical Education National Advisory Committee that there would be a large physician surplus by the year 1990. Moreover, if the upward trend in demand for physicians' services continues, as seems probable, a physician surplus should not develop in the foreseeable future. Only extensive rationing of beneficial services would be expected to alter this projection. (<i>JAMA</i>. 1990;263:557-560)
Cellular and Biochemical Actions of Adrenal Glucocorticoid Hormones on Rat Thymic Lymphocytes
Authors: Donald A. Young, Bruce P. Voris, Mary L. Nicholson
Journal: Environmental Health Perspectives (1981)

The molecular, biochemical, and cellular effects of adrenal glucocorticoid hormones on thymic lymphocytes are reviewed, with emphasis on their relationship to the growth suppressive and lethal actions that occur in lymphoid tissues when glucocorticoids are administered to the whole animal. The data support the hypothesis that the hormonal inhibition of growth and development is a consequence of its ability to suppress cellular energy production, causing the cells to behave as though they were in a more stringent environment. Slight changes in ratios of adenine and guanine nucleotides appear to account for the reordering of metabolic priorities that occurs, with processes related to growth and development curtailed in favor of those more essential to immediate cell survival. The lethal glucocorticoid actions appear to be the result of the operation of separate mechanisms (unrelated to energy metabolism) that lead to lethal attack at the level of the nuclear membrane. Resistance to the lethal effects appears to occur via the selection (in the case of cancer cells where the animal or patient is undergoing chemotherapy with glucocorticoids) or the normal development (in the case of immunologically noncommitted thymocytes progressing to immunologically committed ones) of cells with hardier membranes. This progression is associated with a change in a few cellular proteins. One such protein appears identical in both kinds of cells, offering itself as a candidate for an intracellular mechanism conferring resistance. Evidence is also presented for the appearance of hormone-induced proteins that could be metabolic regulators that mediate the individual cellular and biochemical actions of glucocorticoids. It is proposed that toxins could alter cellular metabolism through mechanisms similar to those utilized by steroid hormones, or possibly alter the sensitivity of cells to steroids, or vice versa.