tbuckley/cabot-search huggingface dataset:
British, American reports on xenotransplantation
Authors: C. Marwick
Journal: JAMA (1996)

TWO REPORTS on the current status of xenotransplantation and the circumstances under which it can safely proceed were presented last month in Washington, DC. One comes from the United States' Institute of Medicine (IOM) and the other from Great Britain's Nuffield Council on Bioethics. Each report was discussed by those who prepared it at a meeting held by the IOM. Essentially, the message was the same: when using animals as a source of organs, tissues, or cells for transplantation to humans, proceed with care if you proceed at all; recognize clearly the risks involved; xenotransplantation requires appropriate safeguards that are not yet in place. The procedures are still experimental. <h3>Central vs Local Control</h3> The British report,<i>Animal-to-Human Transplants: The Ethics of Xenotransplantation</i>, is more cautious and calls for more centralized regulation than does the US report,<i>Xenotransplanta</i><i>tion: Science, Ethics, and Public Policy</i>. The latter, while also calling for specific
Manuel de neurologie. Tome I. L'anatomie du système nerveux: Une tentative de grouper en système fonctionnel, les voies et les centres de localisation diverse, par lesquels les diverses impressions sensorielles peuvent se traduire en réactions réflexes
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Paralytic syndromes associated with noninflammatory cytoplasmic or nuclear neuronopathy. Acute paralytic disease in Mexican children, neuropathologically distinguishable from Landry-Guillain-Barre syndrome
Authors: M. Ramos-Alvarez
Journal: JAMA (1969)

Postmortem studies on 57 Mexican children with acute, lower motor neuron paralytic disease indicated that 32 had poliomyelitis and 25 had no inflammatory changes in the central nervous system. In the latter group, ten exhibited neuropathologic changes compatible with a diagnosis of Landry-Guillain-Barré syndrome; eight, showing extensive chromatolysis of the majority of lower motor neurons, were categorized as "cytoplasmic neuronopathy"; and seven, showing an argyrophil, degenerative change of the nuclei of the majority of lower motor neurons but no chromatolysis, were categorized as "nuclear neuronopathy." The interval between onset of paralysis and death was longer than one week (10 to 30 days) in 70% of the Landry-Guillain-Barré group, one week or less in 75% of the cytoplasmic neuronopathy group, and less than one week in 86% of the nuclear neuronopathy group.
Anus, Rectum, Sigmoid Colon: Diagnosis and Treatment
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Oto-Rhino-Laryngology for the Student and Practitioner.
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Serial plasma carcinoembryonic antigen measurements during treatment of metastatic breast cancer
Authors: A. W. Mughal
Journal: JAMA (1983)

Serial plasma carcinoembryonic antigen (CEA) levels were measured in 167 patients with metastatic breast cancer treated with fluorouracil, doxorubicin hydrochloride, and cyclophosphamide (FAC). In 84 patients, the pretreatment CEA value was abnormal. Response rates and remission duration were similar in patients with normal and abnormal pretreatment levels. Carcinoembryonic antigen concentrations decreased in 94% of patients who responded to FAC therapy. The duration of response was 22 months for patients in whom the CEA levels normalized<i>v</i>nine months in those in whom it decreased but never returned to normal. Increasing CEA levels correlated with progressive disease in 87% of patients and preceded clinical evidence of progression in 77%. Serial CEA measurements can monitor response to chemotherapy, provide useful prognostic information of response duration, and detect progressive disease early. (<i>JAMA</i>1983;249:1881-1886)
Impact of the Medicare fee schedule on an academic department of medicine
Authors: D. J. Shulkin
Journal: JAMA (1991)

<h3>Objective.</h3> —To examine the effect of the Medicare Fee Schedule (MFS) on Medicare revenues in the department of medicine at an urban academic medical center after the MFS is fully implemented. <h3>Methods.</h3> —Department revenues from Medicare were compared with projected revenues using the MFS proposed by the Health Care Financing Administration on June 5, 1991. National Medicare claims data were used to determine differences in service mix between community and academic internists and the impact of the geographic component of the MFS on department revenues. <h3>Results.</h3> —Department revenues from Medicare in 1996 are projected to be 25.5% lower under the MFS than if the current system had continued. Subspecialty sections that perform large numbers of procedures and special tests had the largest decrease in revenues (eg, gastroenterology, - 29.8%); however, this did not differ greatly from decreases in sections that mainly provide visits and consultations (eg, general internal medicine, -24.7%). <h3>Conclusion.</h3> —The proposed MFS is projected to lead to substantial reductions in department revenues from Medicare. While relative values for services and geographic location will play a role in how individual departments fare under the MFS, the value of the conversion factor used in the final MFS will be the factor of greatest importance. (<i>JAMA</i>. 1991;266:3000-3003)
Leitfaden der einheimischen Wurmkrankheiten des Menschen
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Concentric remodeling is accompanied by an impairment of aortic mechanics, and an increased urinary albumin excretion rate in untreated essential hypertensive subjects with normal left ventricular mass Constantinos Tsioufis, Christodoulos Stefanadis, Marina Toutouza, Ioannis Kallikazaros, Christos Pitsavos, Kostas Toutouzas, Kostas Xenakis, Sofia Vaina, Eleftherios Tsiamis, Pavlos Toutouzas. HIPPOKRATION HOSPITAL, ATHENS, Greece
Journal: Journal of the American College of Cardiology (2001)
CORRIGENDA.
Journal: JAMA (1888)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Massive bleeding from hemorrhoidal varices in portal hypertension
Authors: K. Johansen
Journal: JAMA (1980)

GASTROINTESTINAL bleeding in patients with portal hypertension frequently results from ruptured esophagogastric varices. Although an alternative site of natural decompression of the portal system occurs via communications from the superior hemorrhoidal to the middle and inferior hemorrhoidal veins through the submucosa of the distal rectum, severe bleeding from such hemorrhoidal varices has rarely been reported. The management of such bleeding is a matter of conjecture, and recommendations range from watchful waiting to the performance of a portasystemic shunt.<sup>1,2</sup>Our recent experience with a cirrhotic patient who bled massively from hemorrhoidal varices is illustrative of the problem and suggests a rational approach to therapy. <h3>Report of a Case</h3> A 55-year-old man with known alcoholic cirrhosis, portal hypertension, ascites, and esophageal varices was admitted to the Medicine Service of the Veterans Administration Hospital, San Diego, because of rectal bleeding. For several months before this hospital admission, he had had numerous episodes
Abstract 5300: LIN9 as a potential negative regulator of the glioblastoma stem cell state
Authors: Farid Farkouh, Milan G. Chheda, Arijita Jash
Journal: Cancer Research (2019)

Abstract Introduction: Glioblastoma (GBM) is the most lethal primary brain tumor. The GBM stem cells are treatment-resistant cells. We performed an RNAi screen to identify genetic drivers of the GSC state. LIN9 suppression scored strongly in the opposite direction: LIN9 suppression led to a significant increase in neurosphere size and number. In other cellular contexts, LIN9 interacts with pRB and cooperates to promote differentiation. It also inhibits DNA synthesis and oncogenic transformation. The purpose of this study is to better understand the role of LIN9 in GBM. Methods: Lentivirus for suppression and overexpression of LIN9 was produced via transfection of 293T cells. We transduced patient-derived 0308 GSCs. qRT-PCR was used to determine the expression of various genes. Results: LIN9 suppression in 0308 GSCs results in increased sphere formation and increased cell proliferation but not increased cell size. Additionally, LIN9 suppression results in upregulation of Sox2 in human astrocytes. In contrast, LIN9 overexpression in 0308 cells results in decreased sphere formation and decreased proliferation. Further ongoing experiments will determine if suppression and overexpression of LIN9 have an effect on the expression of stem cell markers (ex. SOX2, Nestin, OLIG2) and differentiation markers (ex. GFAP, MAPK2, GAL4). We expect LIN9 suppression will result in an increase in the expression of stem cell markers and a decrease in expression of differentiation markers. We also expect the opposite results for LIN9 overexpression. Conclusions: LIN9 is a potentially important negative regulator of the glioblastoma stem cell state. Citation Format: Farid Farkouh, Milan G. Chheda, Arijita Jash. LIN9 as a potential negative regulator of the glioblastoma stem cell state [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 5300.
Bone Marrow Transplantation
Authors: William R. Best
Journal: JAMA (1967)

There was a great surge of interest in the apparent potentialities of bone marrow transplantation in the late 1950's, when it was discovered that to lethally irradiated animals marrow could be transplanted with life-saving effects. Many experimental and clinical studies followed. It soon became apparent that, with available techniques, the clinical potentialities of this procedure fell far short of what had been hoped for, and many investigators turned their efforts elsewhere. A number, including the author and his colleagues, have continued to study this intriguing area. He pauses at this time to examine the present state of the art. In so doing he presents an excellent, welldocumented review of pertinent animal studies, clinical trials, and technical methods. Allogenic transplants in man (from an individual who is not an identical twin) have been tried in a number of diseases and under various conditions of irradiation or radiomimetic drug administration. The author
Abstract 187: Endothelial Cell Function in Young Adults with History of Kawasaki Disease
Authors: Lori B Daniels, Matthew Vejar, Andrew M Kahn, John B Gordon, Jane C Burns
Journal: Circulation (2015)

Background: The endothelium is a single layer of epithelial cells that lines the blood vessels and is a major component in maintaining vascular homeostasis. Impaired endothelial cell (EC) function can contribute to cardiovascular disease states, but whether there is an association between endothelial dysfunction and the presence of coronary artery aneurysms after Kawasaki disease (KD) is unknown. Methods: We enrolled 110 teens and young adults, ages 16 to 30 years, with a history of KD (61% male), as well as 30 healthy controls (HC, 53% male). EC function (reactive hyperemic response after a 5 minutes brachial artery occlusion) was measured using the EndoPAT 2000. Reactive hyperemia index (RHI) and PAT ratios were determined. KD subjects were categorized based on their worst coronary artery status (normal, transiently dilated/resolved aneurysm, aneurysm). Results: The mean age of KD subjects and HC at the time of EndoPAT was 25 ± 9 and 26 ± 7 years, respectively (p=0.42). Mean time since onset of KD was 23 ± 19 years. Subjects with a history of transiently dilated/resolved aneurysms had a higher mean lnRHI compared to other KD subjects (0.91 vs 0.74, p=0.01) and HC (0.72, p=0.02). When PAT ratio was evaluated as a function of time after occlusion release, those with transiently dilated/resolved aneurysms had a trend toward a more favorable profile while other groups appeared similar (Figure). Conclusion: Most young adults with a history of KD have normal EC function. Individuals with a history of transiently dilated coronary arteries had a paradoxical trend toward better EC function, which may indicate healthier vasculature. The significance of this finding merits further study.
SECTION OF DERMATOLOGY
Authors: J. Franklin
Journal: British Journal of Dermatology (1964)

Journal Article SECTION OF DERMATOLOGY Get access J. Franklin J. Franklin Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 76, Issue 5, 1 May 1964, Pages 229–232, https://doi.org/10.1111/j.1365-2133.1964.tb14515.x Published: 01 May 1964
Role of Hypotension in the Genesis of Transient Focal Cerebral Ischemic Attacks
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 2788: The interplay between tumor-cell derived FoxO1 and macrophage in the tumor microenvironment of esophageal squamous cell carcinoma
Authors: Ying Wang, Xinyuan Guan, Woon Ngar Kam
Journal: Cancer Research (2019)

Abstract Introduction: Esophageal squamous cell cancer (ESCC) is the predominant histologic type in China with high incidence and mortality. FOXO1 is considered as a tumor suppressor in several cancers, but its role in tumor immunology still remain elusive. A better understanding of how FOXO1 mediates the secretion of downstream chemokines, such as CCL20, and thus its ability in regulating macrophage function would be of crucial for further investigation. Materials and Methods: Quantitative PCR and immunohistochemistry were used to study the expression of FoxO1 in clinical ESCC samples. The survival analysis was performed based on the result of tissue microarray and corresponding clinicopathological information. Stable foxo1-transfected cell lines were constructed in human ESCC cell lines, and ELISA, western blotting and Quantitative PCR were conducted to evaluate the expression of foxo1 and its downstream molecule CCL20. The subsets of macrophages were identified through Flow cytometry and qPCR. Results: The expression of FOXO1 was significantly upregulated in tumorous tissue when comparing to adjacent normal tissue and predicted a poor prognosis in ESCC patients. Besides, the analysis of TCGA database indicated that the markers of M2 macrophage were upregulated in foxo1-high expressing tumor tissues when compared with foxo1-low expressing tumor tissues. In vitro, we have successfully differentiated monocytic cell line THP-1 into macrophage M0, M1 and M2. The M1 and M2 markers (CD80, CD163 and CD68) were measured by flow cytometry, while their major cytokines (IL6, TNF-α, CCL17, CCL18, IL1β and IL10) were detected by qPCR. The ELISA, western blot and qPCR results showed that the expression of CCL20 was upregulated in foxo1-high expressing tumor cells when compared to negative control. The migration assay showed that ESCC cells transfected with foxo1 could recruit more M2 macrophages when compared with foxo1-low expression ESCC cells and the effect was diminished upon blockade with anti-CCL20 neutralizing antibody in tumor cells. Besides, we found out that M2 macrophage could promote the migration and EMT of tumor cells by using M2 conditioned medium. Conclusions: FoxO1 displays an important role in M2 macrophage migration through the modulation of CCL20. This increased CCL20 reported in ESCC may become specific molecular/cellular processes operative in the TME of ESCC patients. Note: This abstract was not presented at the meeting. Citation Format: Ying Wang, Xinyuan Guan, Woon Ngar Kam. The interplay between tumor-cell derived FoxO1 and macrophage in the tumor microenvironment of esophageal squamous cell carcinoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2788.
Phencyclidine
Authors: Craig B. Liden
Journal: JAMA (1975)

In nine cases of phencyclidine hydrochloride poisoning, early signs of overdose included drowsiness, nystagmus, miotic pupils, blood pressure elevation, increased deep tendon reflexes, ataxia, anxiety, and agitation. In more severe cases, seizures, spasticity, and opisthotonos were seen in addition to deep coma and respiratory depression. Treatment included removal by emetics or lavage, hydration, and a quiet, reassuring environment. Spasticity, agitation, and ocular manifestions responded to diazepam. Psychiatric intervention was instituted after the patients were stable and no longer agitated. (<i>JAMA</i>234:513-516, 1975)