tbuckley/cabot-search huggingface dataset:
Effects of cotadutide on biomarkers of non-alcoholic steatohepatitis in overweight or obese subjects with type 2 diabetes mellitus: a 54-week analysis of a randomized phase 2b study
Authors: Rajaa Nahra, Kishore Gadde, Boaz Hirshberg, Lutz Jermutus, Jill Maaske, Michael Stumvoll, Tao Wang, Philip Ambery
Journal: Journal of Hepatology (2020)
Combination of extracorporeal shock-wave lithotripsy and dissolution of gallbladder stones with methyl tert-butyl ether: A randomized study
Authors: M Neubrand
Journal: Hepatology (1994)

We conducted a prospective randomized study in gallstone patients to determine whether a combination of extracorporeal shock-wave lithotripsy and subsequent dissolution with methyl tert-butyl ether increases the success rate of methyl tert-butyl ether dissolution and shortens treatment time compared with monotherapy with methyl tert-butyl ether. Fifty patients were randomized into two groups. Twenty-five patients underwent extracorporeal shock-wave lithotripsy before contact dissolution with methyl tert-butyl ether, and 25 patients were treated with methyl tert-butyl ether alone. All patients had at least three stones or stones larger than 30 mm that were radiolucent on x-ray and had densities of less than 140 Hounsfield Units (HU) on computed tomography. Overall, the combined approach neither shortened the treatment time significantly vs. monotherapy with methyl tert-butyl ether nor reduced the time of hospitalization. The success rate was slightly but not significantly increased compared with that of methyl tert-butyl ether therapy alone. The recurrence rate was similar in the two groups after a median follow-up of 1 yr. However, when subgroups of patients with at least one stone larger than 15 mm or with stones with densities of more than 60 HU were analyzed, the clearance rate after 5 mo was significantly higher (p < 0.005 and p < 0.025, respectively) in patients subjected to a combination of extracorporeal shock-wave lithotripsy and methyl tert-butyl ether dissolution. Extracorporeal shock-wave lithotripsy and methyl tert-butyl ether did not expose patients to more adverse effects than did treatment with methyl tert-butyl ether alone. (Hepatology 1994;19:133–137).
BEHRING'S ALLEGED CURE FOR TUBERCULOSIS.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Surgeon General emphasizes nicotine addiction in annual report on tobacco use, consequences
Authors: P. Gunby
Journal: JAMA (1988)

NICOTINE ADDICTION is the subject of the 20th report of the Surgeon General of the Public Health Service on the health consequences of tobacco use. Its major conclusions are: Cigarettes and other forms of tobacco are addicting. Nicotine is the drug in tobacco that causes addiction. The pharmacologic and behavioral processes that determine tobacco addiction are similar to those that determine addiction to drugs such as heroin and cocaine. In his foreword to the seven-chapter report, which was issued this week, Robert E. Windom, MD, Assistant Secretary for Health, emphasizes: "Recognizing tobacco use as an addiction is critical both for treating the tobacco user and for understanding why people continue to use tobacco despite the known health risks. Nicotine is a psychoactive drug with actions that reinforce the use of tobacco. Efforts to reduce tobacco use in our society must address all the major influences that encourage continued use, including
Abstracts
Journal: Annals of the Rheumatic Diseases (1972)

Over an 11-year period, 201 male patients were given in-patient treatment and rehabilitation in the Rheumatic Diseases Unit of the Canadian Arthritis and Rheumatism Society in Vancouver.The authors analyse the ability of those men who had rheumatoid arthritis to return to work.The mean duration of their disease was 7*9 years, and the time spent in the unit averaged 79 days.This report is based on the 94 men who were followed up adequately (for a mean period of 3-5 years) and who were under 65 years of age at follow-up.Among the 94 were 24 men who were admitted 'to improve self-care only', with no real prospect of returning to work.Before admission 40 per cent. of the 94 men were work- ing, often keeping theirjobs with difficulty, but at follow-up 58 per cent.were competitively employed.This proportion was higher in the city dwellers (65 per cent.)than in country dwellers (50 per cent.),among whom opportunities for suitable occupation were more limited, and the possibilities of changing jobs restricted.No country dweller, however, decided to move into the city for work purposes.The level of educational attainment was also related to the ability to return to work; in the city the employment rate among those with higher education levels was nearly double that among men with lower levels, and in the country this ratio was nearly three to one.Among the city dwellers, six men whose families were previously dependent on social welfare became self- supporting again.It is calculated that the saving in welfare costs, and the additional revenue in taxes from these families, represents an annual gain to the community of over $35,000.
Diabetes, New York
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Perforation of peptic ulcer after withdrawal of cimetidine.
Authors: S Shalet, C Beardwell, Dorothy Pearson, P H Morris Jones
Journal: BMJ (1977)

trophin-releasing hormone (TRH).Seven patients showed evidence of primary pituitary deficiency, five of whom showed low thyroid function, while the basal serum TSH level was not elevated and failed to rise after TRH administration.Thus damage to both the normal hypothalamus and the normal pituitary gland may occur following irradiation in the dose range 5000-8300 rads.Further points in the article concern the effects on GH production of neurosurgery and radiation to parts of the brain other than the hypothalamic-pituitary region.We have studied more than 30 children after neuro- surgery and before irradiation.No child has shown impaired GH responses to provocative stimuli before irradiation.Furthermore no child whose hypothalamic-pituitary axis totally avoided irradiation has ever shown inadequate GH responses.Much more interesting is the question whether or not irradiation of other parts of the brain may interfere with somatic growth by a non-GH-mediated mechanism.There is some evidence that this occurs in the rat.4 fi Finally, the question is raised at the end of your article about possible growth responses to exogenous GH.We have six children with radiation-induced GH deficiency on GH therapy.The mean growth velocity during the pretreatment year was 3 7 cm and during the first year of GH therapy 7 9 cm.These data have not yet been published,:' but other authors have described similar increases in growth velocity with GH therapy in such children.
Die Syphilis. Kurzes Lehrbuch der gesamten Syphilis, mit besonderer Berücksichtigung der inneren Organe.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diseases of the Eye.
Journal: JAMA (1899)

In this third edition new matter is added and the greater part of the work is thoroughly revised, especially the articles on "Tumors of the Choroid," "Retinitis Carcinomata," "Hereditary Optic Nerve Atrophy," "Orbital Optic Neuritis," and the chapter on operations. The bacteriologic relationship to many of the ocular diseases is emphasized. All through the work there is evidence of the desire of the author to keep the book thoroughly up to date.
Sweat Electrolytes in Adults with Peptic Ulcers
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A phase I pharmacokinetics trial comparing PF-05280014 (a potential biosimilar) and trastuzumab in healthy volunteers (REFLECTIONS B327-01).
Authors: Donghua Yin, Kerry B. Barker, Ruifeng Li, Xu Meng, Steven D. Reich, Alejandro D. Ricart, Dan Rudin, Carrie T. Taylor, Charles M. Zacharchuk, Arne G. Hansson
Journal: Journal of Clinical Oncology (2013)

171 Background: PF-05280014, a proposed biosimilar to trastuzumab, has an identical amino acid sequence and similar physicochemical and in vitro functional properties to trastuzumab. This study was designed to demonstrate PK similarity of PF-05280014 to trastuzumab from the US (trastuzumab-US) and EU (trastuzumab-EU), and between the licensed drugs. Safety and immunogenicity were also evaluated. Methods: In this double-blind trial (NCT01603264), 105 healthy male volunteers, 18-55 years old were randomized 1:1:1 to receive a single 6 mg/kg IV dose of PF-05280014, trastuzumab-US or trastuzumab-EU. All subjects provided informed consent. PK, safety and immunogenicity assessments were conducted for 70 days. PK similarity for a given test-to-reference comparison was considered to be demonstrated if the 90% CI of the test-to-reference ratio of the AUC from time 0 to the last time point (AUC T ) and maximum concentration (C max ) were within 80% – 125%. Results: The baseline demographics for the 101 subjects evaluable for PK were similar among 3 treatment arms. The 3 study drugs exhibited similar characteristics of target-mediated disposition and similar PK parameters (Table). The 90% CI for the ratios of C max , AUC T , and AUC 0-∞ were within 80% – 125% for the comparisons of PF-05280014 to trastuzumab-EU or trastuzumab-US, and trastuzumab-EU to trastuzumab-US. Adverse events (AE) were similar for the 3 arms with treatment-related AEs reported by 71.4%, 68.6%, and 65.7% subjects in the PF-05280014, trastuzumab-EU and trastuzumab-US, respectively. No serious AEs were reported. Only 4 subjects had treatment interruptions; 2 discontinued. Only 1 subject (trastuzumab-EU) developed anti-drug antibodies after dosing. Conclusions: This study demonstrates PK similarity of PF-05280014 to both trastuzumab-US and trastuzumab-EU and of trastuzumab-EU to trastuzumab-US. The 3 study drugs also showed similar safety profiles. Clinical trial information: NCT01603264. [Table: see text]
PHENOL AND INDICAN EXCRETION IN A CASE OF TETANY OF INTESTINAL ORIGIN
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
DISEASES AND HOSPITALS OF THE EAST COAST OF AFRICA.
Authors: NICHOLAS SENN
Journal: JAMA (1906)

Salisbury, Mashonaland, June 8, 1906. <h3>GERMANY'S BATTLE WITH TROPICAL DISEASES IN EAST AFRICA.</h3> Since Germany has become interested politically and commercially in the future welfare of Africa by acquiring possessions, one on the west and the other on the east coast, she has entered earnestly and systematically in the battle against disease by contributing her lion's share to the elucidation of the nature of tropical disease and to the discovery of ways and means for their prevention and cure. If she had done nothing else in getting her modest share in apportioning and redistributing the continent, she would be excusable in taking such an active part in the stupendous struggle of the nations of the Old World for supremacy. Under the pretext of bringing the untutored savage tribes of Africa under the influence of civilization and christianization, the geography of the country has been entirely changed, and nearly all the
Miscellany
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Carcinogenicity of Black Rock Harbor sediment to the eastern oyster and trophic transfer of Black Rock Harbor carcinogens from the blue mussel to the winter flounder.
Authors: G R Gardner, P P Yevich, J C Harshbarger, A R Malcolm
Journal: Environmental Health Perspectives (1991)

The eastern oyster (Crassostrea virginica) developed neoplastic disorders when experimentally exposed both in the laboratory and field to chemically contaminated sediment from Black Rock Harbor (BRH), Bridgeport, Connecticut. Neoplasia was observed in oysters after 30 and 60 days of continuous exposure in a laboratory flow-through system to a 20 mg/L suspension of BRH sediment plus postexposure periods of 0, 30, or 60 days. Composite tumor incidence was 13.6% (49 neoplasms in 40, n = 295) for both exposures. Tumor occurrence was highest in the renal excretory epithelium, followed in order by gill, gonad, gastrointestinal, heart, and embryonic neural tissue. Regression of experimental neoplasia was not observed when the stimulus was discontinued. In field experiments, gill neoplasms developed in oysters deployed in cages for 30 days at BRH and 36 days at a BRH dredge material disposal area in Central Long Island Sound, and kidney and gastrointestinal neoplasms developed in caged oysters deployed 40 days in Quincy Bay, Boston Harbor. Oysters exposed to BRH sediment in the laboratory and in the field accumulated high concentrations of polychlorinated biphenyls (PCBs), polyaromatic hydrocarbons (PAHs), and chlorinated pesticides. Chemical analyses demonstrated high concentrations of PCBs, PAHs, chlorinated pesticides, and heavy metals in BRH sediment. Known genotoxic carcinogens, co-carcinogens, and tumor promoters were present as contaminants. The uptake of parent PAH and PCBs from BRH sediment observed in oysters also occurs in blue mussels (Mytilus edulis). Winter flounder fed BRH-contaminated blue mussels contained xenobiotic chemicals analyzed in mussels. The flounder developed renal and pancreatic neoplasms and hepatotoxic neoplastic precursor lesions, demonstrating trophic transfer of sediment-bound carcinogens up the food chain.
Hemoglobin A1c in normal and diabetic pregnancy
Authors: J. M. Miller
Journal: JAMA (1979)

The usefulness of determining hemoglobin A<sub>1c</sub>(HbA<sub>1c</sub>) levels during pregnancy was evaluated. In contrast to previous reports, the HbA<sub>1c</sub>values did not predict abnormal maternal glucose tolerance or infant birth weight. They did, however, correlate with long-term control of the diabetes of pregnant insulin-dependent patients. The slight decrease in HbA<sub>1c</sub>values observed as pregnancy advanced was secondary to improved control of diabetes. (<i>JAMA</i>242:2785-2787, 1979)
EPID-05. PREDIAGNOSTIC SYMPTOMS AND SIGNS OF ADULT GLIOMA: THE PATIENTS’ VIEW
Authors: Marthe Peeters, Linda Dirven, Johan Koekkoek, Ellen Gortmaker, Lara Fritz, Maaike Vos, Martin Taphoorn
Journal: Neuro-Oncology (2019)

Abstract BACKGROUND Little is known about the symptoms/signs glioma patients experience in the year before diagnosis, either or not resulting in health care usage. The objective of this study was to determine the incidence of symptoms/signs glioma patients experienced in the year prior to diagnosis, as well as visits to a general practitioner (GP) related to these issues. METHODS Glioma patients were asked to complete a 30-item study-specific questionnaire, if possible with input of a proxy, focusing on symptoms and signs they experienced in the 12 months before diagnosis. For each indicated symptom/sign, patients were asked whether they consulted the GP for this issue. RESULTS Between July 2016 and April 2019, 59 patients completed the questionnaires, 54 (93%) with input of a proxy. Forty (68%) patients were men, with a median age of 60 years and the median time since diagnosis was 4 months (range 1–12). The median number of symptoms/signs experienced in the year before diagnosis was 9 (range 2–19) in low-grade and 5 (range 0–24) in high-grade glioma (p=0.230). The five most frequently mentioned problems were fatigue (34, 58%), mental tiredness (30, 51%), sleeping disorder (24, 41%), headache (23, 39%) and stress (20, 34%), with no differences between low- and high grade glioma. Twenty-six (44%) patients had visited the GP with at least one issue. We found that patients who did consult their GP reported significantly more often muscle weakness (11 vs 3, p =0.003) than patients who did not, which remained significant after correction for multiple testing, which was not the case for paralysis in hand/leg (10 vs 4), focussing (11 vs 6) or a change in awareness (9 vs 4). CONCLUSIONS Glioma patients experience a range of problems in the year prior to diagnosis, but patients who consult the GP report significantly more often neurological problems.