tbuckley/cabot-search huggingface dataset:
Abstract 063: Rapid Induction of Aldosterone Synthesis in Cultured Neonatal Rat Cardiomyocytes under High Glucose Conditions
Authors: Tomohisa Nagoshi, Masami Fujisaki, Tetsuo Nishikawa, Taro Date, Michihiro Yoshimura
Journal: Circulation Research (2013)

Background: In addition to the classical adrenal cortical biosynthetic pathway, there is increasing evidence that aldosterone is produced in extra-adrenal tissues. Although we have previously reported that aldosterone is produced in the heart, the concept of cardiac aldosterone synthesis remains controversial. This is partly due to the lack of established experimental models representing the aldosterone synthase gene (CYP11B2) expression in a robustly reproducible fashion. Therefore, in this study, we investigated suitable conditions in a neonatal rat cardiomyocytes culture system producing CYP11B2 with considerable efficacy. Methods and Results: Neonatal rat cardiomyocytes were cultured in serum-free medium containing various doses of glucose for two to 24 hours. The CYP11B2 mRNA expression in the cardiomyocytes was determined using real-time PCR, and the aldosterone concentrations secreted from the cardiomyocytes into the culture medium were measured using an enzyme immunoassay. We found that suitable conditions for inducing the cardiac aldosterone gene expression included four hours of incubation with high glucose conditions (&gt;25 mM). Under these particular conditions, the CYP11B2 expression (2.18±0.37-fold, p&lt;0.01), in accordance with aldosterone secretion, was significantly increased compared to that observed in the cells cultured under standard glucose condition (5.5 mM). Conclusions: The suitable conditions for detecting the CYP11B2 expression and aldosterone secretion in the neonatal rat cardiomyocytes culture system are now clarified: high glucose conditions with a relatively brief period of culture promote the CYP11B2 expression as well as aldosterone production/secretion in cardiomyocytes. The current system will help to accelerate further progress in research on cardiac tissue aldosterone synthesis.
Hernia and Its Radical Cure.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
'Realities of medicine:' a week of the future
Authors: B. Merz
Journal: JAMA (1982)

It is a Sunday morning late in August. A few casually but neatly dressed young men and women exchange greetings and anecdotes as they survey the brunch buffet: plump blueberries in a handcrafted ceramic bowl, coffee cakes stuffed with nuts and fruit, a chafing dish of spiced sausage, and pitchers of coffee and apple cider. They fill their plates and join the other guests in the sun-dappled living room. Throughout the summer, this group—mostly medical students—has enjoyed many such Sunday gettogethers at this home in Evanston, Ill. The brunches, which have become something of a tradition, are actually planning sessions for another tradition, "The Realities of Medicine," a week-long program designed to acquaint second-year medical students at the University of Illinois College of Medicine at Chicago with issues pertinent to the art and practice of medicine before they embark on their clinical rotations. The program is the brainchild of the
Tryptase in nasal lavage fluid after local allergen challenge: Relationship to histamine levels and TAME‐esterase activity
Authors: S. Juliusson, K. Holmberg, C. R. Baumgarten, M. Olson, I. Enander, U. Pipkorn
Journal: Allergy (1991)

The activation of mast cells is generally considered to be an important trigger mechanism in the immediate allergic response. This study focused on the determination of three markers of mast cell activation after an allergen challenge. Nasal allergen challenges were performed in 25 subjects with seasonal allergic rhinitis using three allergen doses increasing in 10‐fold steps in a standardised nasal lavage model for the subsequent recovery of the markers of mast cell activation. The levels of histamine and tryptase in the nasal lavage fluid were determined using radioimmunoassays, while the TAME‐esterase activity was determined using a radiochemical technique. The nasal symptoms obtained on challenge were assessed using a scoring technique. The allergen challenge resulted in significant increases in the levels of all three markers, tryptase, histamine and TAME‐esterase. In the individual measurements after the challenges there was a highly significant correlation between the TAME‐esterase levels and the tryptase levels (r = 0.71; P &lt; 0.001), while the generation of histamine and tryptase was not significantly correlated. When comparing the cumulative generation of the three markers, significant correlations were found between all three. Allergen challenges in six non‐allergic controls using the same technique did not result in any increase in tryptase levels. The findings suggest that the determination of tryptase in nasal lavage fluid may be a valuable indicator of mast cell activation in the upper airways.
Localized, sustained-release drug delivery uses membrane 'envelope'
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MISCELLANY.
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MEDICAL NEWS
Journal: JAMA (1953)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clippings from Lay Exchanges.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pulmonary Sporotrichosis
Authors: George Kobayashi
Journal: JAMA (1969)

Dr. John Arradondo, Junior Assistant Resident in Medicine, Jewish Hospital of St. Louis, and Assistant in Medicine, Washington University School of Medicine: This is the third admission of a 61-yearold white woman florist with peripheral vascular disease and persistent and recurrent leg ulcers. The patient was admitted at this time for evaluation and possible correction of the peripheral arterial insufficiency. Three years ago the patient was found to have cutaneous ulcerations over the left ankle which healed with antibiotics. For several years, however, she had had generalized and recurrent small cutaneous nodules that occasionally ulcerated but always healed. Those nodules were frequently arrayed along the lymphatic pathways, but were not associated with edema. In the past two years the patient has had mild night sweats, increased fatigue with a variable, productive cough, and a 11.3-kg (25-lb) weight loss. There was no hemoptysis, fever, dyspnea, or edema. About a year prior
Helvetica Chirurgica Acta, Basel
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prenatal diagnosis of genetic disorders. An analysis of experience with 600 cases
Authors: A. Milunsky
Journal: JAMA (1974)

Prenatal diagnosis of hereditary disorders is now an established part of routine antenatal care. This report of our experience with 600 cases indicates that advanced maternal age is by far the commonest indication for amniocentesis. Chromosomal or metabolic abnormalities were diagnosed in 15 fetuses. In addition, four fetuses were determined to be male in the sex-linked group. The parents elected termination of the pregnancies in 13 cases. Reassurance was provided to more than 95% of mothers studied. Every physician is urged to offer these prenatal genetic studies when indicated or to seek consultation when in doubt. (<i>JAMA</i>230:232-235, 1974)
Transvaginal ultrasonography.
Authors: R. K. Goswamy
Journal: BMJ (1992)

Readers looking for a shortcut to understanding evidence the turn of the century it will be possible to replace traditional about health problems and patient care should at least look for textbooks in the main specialties.reviews by those who have not taken shortcuts.Summarising the results of research to provide tools for At their best, the new breed of scientific reviews (often clinical practice will be hastened if those who write reviews referred to as overviews) can resolve controversy generated by follow the new standards, editors and reviewers of journal studies that seem to contradict one another and provide much articles apply these standards in selecting reviews for publica- clearer conclusions by quantitatively pooling the results of tion, and readers direct their attention to scientific reviews, inconclusive studies-"meta-analysis."A good example is the bypassing those that are not.recent clarification of the role of blood pressure reduction in R BRIAN HAYNES reducing the risk of coronary artery disease.89Of course, Professor of Clinical Epidemiology and Medicine, even when reviews are done scientifically they can review McMaster University, only the evidence that is available, which may be limited Hamilton, in ways that preclude definitive conclusions, even in the OntardoL8N3Z5, aggregate.To be of continuing guidance to practitioners reviews
Acute, Complete Gastric Volvulus
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Vigil
Authors: George N. Braman
Journal: Annals of Internal Medicine (2007)

Ad Libitum20 March 2007VigilGeorge N. Braman, MDGeorge N. Braman, MDFrom Bronx, NY 10471.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-146-6-200703200-00010 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Too long my watch has been surprised by Death.How hard I try I cannot catch him out.When at the bedside, watching breath by breathAs patients cling to life, there steals a doubt(A sudden change in rhythm, a long pause),My senses snap alert, I glance about;Just when my back is turned, without a cause,Life stopped, as a candle flickers out.And still I keep my vigil in the nightHoping some better angel grants reprieve,Or skillful craft or art or guiding lightMight summon help to heal or to relieve.I must be patient then to watch and seeLest that stealthy Angel surprises me.George ... Author, Article, and Disclosure InformationAffiliations: From Bronx, NY 10471.Current Author Address: George N. Braman, MD, 6142 Delafield Avenue, Bronx, NY 10471. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 20 March 2007Volume 146, Issue 6Page: 442 ePublished: 20 March 2007 Issue Published: 20 March 2007 Copyright & PermissionsCopyright © 2007 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
A horizon scan of global conservation issues for 2015
Authors: William J. Sutherland, Mick Clout, Michael Depledge, Lynn V. Dicks, Jason Dinsdale, Abigail C. Entwistle, Erica Fleishman, David W. Gibbons, Brandon Keim, Fiona A. Lickorish, Kathryn A. Monk, Nancy Ockendon, Lloyd S. Peck, Jules Pretty, Johan Rockström, Mark D. Spalding, Femke H. Tonneijck, Bonnie C. Wintle
Journal: Trends in Ecology & Evolution (2014)
Autologous blood transfusion
Authors: P. J. Schmidt
Journal: JAMA (1987)

<h3>In Reply.—</h3> We would concede to Dr Keshgegian that our use of the term "surrogate diagnostic tool" may have been misleading and, perhaps, premature in the absence of supportive evidence. It was not our intention to imply that the presence of oligoclonal paraproteinemia should be used as a definitive test for identifying individuals with antibodies to HIV. However, we maintain our position that the presence of oligoclonal bands in the serum should alert the clinician to the possibility of HIV-related disease and that HIV-related disease should be considered in the differential diagnoses of patients demonstrating oligoclonal paraproteinemia. As a case in point, a clinician, not in our hospital, recently reported to us the following result of reading our letter: a patient with an undiagnosed illness and no association with any high-risk group, in whom oligoclonal paraproteinema had been demonstrated, was tested for antibodies to HIV and found to be seropositive.
Correction
Journal: Circulation (2015)

In the article by Gale et al, “Mental Disorders Across the Adult Life Course and Future Coronary Heart Disease: Evidence for General Susceptibility,” which was published in the January 14, 2014 issue of the journal (Circulation. 2014;129:186–193. DOI: 10.1161/CIRCULATION AHA.113.002065), there were errors in reporting some of the results. Specifically, due to coding mistakes during programming, there were errors in the number of men reported as having been diagnosed with some forms of mental disorder at the conscription examination in early adulthood.
Prurigo pigmentosa
Authors: N.H. COX
Journal: British Journal of Dermatology (1987)

Journal Article Prurigo pigmentosa Get access N.H. COX N.H. COX Department of Dermatology, Western Infirmary Glasgow G11 6NT, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 117, Issue 1, 1 July 1987, Pages 121–124, https://doi.org/10.1111/j.1365-2133.1987.tb04101.x Published: 01 July 1987
'Newscaster' Neurons
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Phase II Study of Induction Therapy with Carboplatin and Gemcitabine among Patients with Locally Advanced Non-small Cell Lung Cancer
Authors: J G.J.V. Aerts, V Surmont, R J. van Klaveren, K Y. Tan, S Senan, G van Wijhe, R Vernhout, G T. Verhoeven, H C. Hoogsteden, J P. van Meerbeeck
Journal: Journal of Thoracic Oncology (2006)