tbuckley/cabot-search huggingface dataset:
Transient urinary tract dilatation associated with hypokalaemia
Authors: R R Ghose
Journal: BMJ (1985)

The association of neonatal hypocalcaemia with hypovitaminosis D in Asians was described 14 years ago, and it is tragic that we still see pregnancy related complications of hypovitaminosis D: neonatal secondary hyperparathyroidism4 and maternal pathological fractures.5We are grateful to Sharon Houlder for measuring 25-hydroxyvitamin D; to Dr M Thomas for assaying parathyroid hormone; and to Pamela Dale for preparing the manuscript.
AMA Officials 1971-1972
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hypertrophic osteoarthropathy.
Authors: H J Burstein, M J Janicek, A T Skarin
Journal: Journal of Clinical Oncology (1997)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1997.15.7.2759 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 9215850 Hypertrophic osteoarthropathy. H J BursteinxH J BursteinSearch for articles by this author , M J JanicekxM J JanicekSearch for articles by this author , A T SkarinxA T SkarinSearch for articles by this author Show More Dana-Farber Cancer Institute, Brigham & Women's Hospital, and Harvard Medical School, Boston, MA, USA. https://doi.org/10.1200/JCO.1997.15.7.2759 PDF "Hypertrophic osteoarthropathy.." Journal of Clinical Oncology, 15(7), pp. 2759–2760© 1997 by American Society of Clinical Oncology
Pilot trial of 5-FU/oxaliplatin (CIFOX) for patients with metastatic colorectal cancer who progressed on 5-FU/LV/CPT-11 (IFL)
Authors: A. Aparicio, S. Iqbal, D. Yang, S. Groshen, D. Park, A. Garcia, H. J. Lenz
Journal: Journal of Clinical Oncology (2004)
A simulation study of the effects of cardiac anatomy in ventricular fibrillation
Authors: F. Xie
Journal: Journal of Clinical Investigation (2004)

In ventricular fibrillation (VF), the principal cause of sudden cardiac death, waves of electrical excitation break up into turbulent and incoherent fragments. The causes of this breakup have been intensely debated. Breakup can be caused by fixed anatomical properties of the tissue, such as the biventricular geometry and the inherent anisotropy of cardiac conduction. However, wavebreak can also be caused purely by instabilities in wave conduction that arise from ion channel dynamics, which represent potential targets for drug action. To study the interaction between these two wave-breaking mechanisms, we used a physiologically based mathematical model of the ventricular cell, together with a realistic three-dimensional computer model of cardiac anatomy, including the distribution of fiber angles throughout the myocardium. We find that dynamical instabilities remain a major cause of the wavebreak that drives VF, even in an anatomically realistic heart. With cell physiology in its usual operating regime, dynamics and anatomical features interact to promote wavebreak and VF. However, if dynamical instability is reduced, for example by modeling of certain pharmacologic interventions, electrical waves do not break up into fibrillation, despite anatomical complexity. Thus, interventions that promote dynamical wave stability show promise as an antifibrillatory strategy in this more realistic setting.
Second-line chemotherapy for advanced non-small cell lung cancer (NSCLC) with weekly versus three-weekly docetaxel: Results of a randomized phase III study
Authors: W. Schuette, S. Nagel, M. Serke, C. Lautenschlaeger, K. Hans, C. Lorenz
Journal: Journal of Clinical Oncology (2004)

7036 Background: Single agent docetaxel, 75 mg/m2 every 3 weeks given second line improves survival compared with other chemotherapeutic regimens or best supportive care in advanced NSCLC. This multicentre phase III study was initiated to compare standard 3-weekly docetaxel with weekly docetaxel as second-line therapy for advanced NSCLC. Methods: Patients (pts) with stage IIB−IV NSCLC were randomized to 3-weekly docetaxel 75mg/m2 (Arm A) or weekly docetaxel 35 mg/m2 for 3 weeks followed by 1 week without therapy (Arm B; 1 cycle=28 days). The primary endpoint is survival and secondary endpoints are toxicity and response. Results: Between April 2000 and September 2003, 216 pts (median age 63.0 yrs; range 41−80 yrs) were enrolled (208 pts planned) and 162 pts (82 pts in Arm A; 80 pts in Arm B) are currently evaluable for toxicity and response. A maximum of 6 treatment cycles (Arm A: median 4 [range: 1−6]; Arm B: median 2 [range: 1−6]) were administered on an outpatient basis and 16% of patients received all 6 cycles. In total, 38 pts (23.5%) had previously received paclitaxel therapy. Reasons for treatment discontinuation (% of 162 pts) included: tumor progression (54%), toxicity (11%) and the patient's request (4%). In Arm A (82 pts), toxicities (WHO grade 3–4) included (% pts): neutropenia (19.4%), infection (3.9%), alopecia (22.7%), fluid retention (5.5%) and pain (13.2%). In Arm B (80 pts), toxicities were infrequent and included: pain (6.6%), nausea (6.6%) neutropenia (4.1%) and neurotoxicity (6.8%). There were no reports of grade 3–4 thrombocytopenia or mucositis and febrile neutropenia occurred in 2.6% pts (Arm A) and 1.3% pts (Arm B). Neutropenia was less frequent in Arm B than in Arm A (p<0.0001). The overall response rates in Arm A and B, respectively were 9.7% and 7.6%. Conclusions: Both regimens are suitable for administration on an outpatient basis and are well tolerated as second-line therapy for advanced NSCLC. Severe toxicity seems less frequent with weekly docetaxel. Unblinded results will be available for ASCO 2004. No significant financial relationships to disclose.
Introduction
Journal: Endoscopy (2003)

No other profession is so influenced by ethics as medicine. Ethics has been an inherent part of medical practice since the ancient times of Hippocrates (480 B.C.). Hippocrates, the father of medicine, was the first to introduce the essential ethical principle of the physician-patient relationship: the physician must benefit and not harm the patient. Since then, medical ethics have determined physicians’ behavior during their professional lives. Medicine requires dedication to the patient as a person and the physician should be committed to the humanistic and ethical principles of medicine for the benefit of patients and society.
Solitary cerebral metastasis from pulmonary cancer. Prolonged survival after surgery
Authors: L. M. Modesti
Journal: JAMA (1975)

THE OUTLOOK for patients with cerebral metastasis of bronchogenic carcinoma is highly unfavorable.<sup>1-2</sup>Patients who have not been operated on have an average life expectancy of three months after the onset of the cerebral symptoms,<sup>1</sup>and the operative mortality of cerebral metastases is as high as 38%.<sup>3</sup>In cases where surgery is apparently instrumental in prolonging life, the quality of survival may be poor.<sup>1</sup>These findings, coupled with the knowledge that cerebral metastases are often multiple,<sup>3-4</sup>have led some authors to conclude that surgery should not be considered the treatment of choice for cerebral metastasis of lung carcinoma.<sup>4</sup> On the other hand, innumerable cases of prolonged, good quality survival following surgery can be found in the literature.<sup>1-3,5</sup>Rarely, there are reports of apparent cures in which patients have lived five years or more beyond craniotomy. This communication reports just such a case. <h3>Report</h3>
An important opportunity. An open letter to the General Medical Council.
Authors: John Ellis, Desmond Laurence, Marshall Marinker, Mr David, Anthony Wakeling, John Yudkin
Journal: BMJ (1984)

This letter is in response to the call by the education committee of the General Medical Council for comment on its proposals for "basic specialist training."It comes from a group of individuals who have been meeting regularly over the past two years to discuss medical education as a whole and the criticisms currently levelled at it by thoughtful observers both outside and inside the profession.*The medical profession in this country continues to experience a high degree of approval and respect from the public.But this is not unqualified.Expectations are rising.Criticism comes more frequently from younger people and therefore seems more likely to increase than to decrease.It is chiefly directed at the balance between technology and humane care.After 50 years of dramatic increase in the power of medicine to intervene effectively there is a growing fear of the side effects of investiga- tion and treatment, increasing awareness of the difficulties of communication between doctor and patient, and dissatisfaction with the relative amounts of time given to combating disease, comforting individuals, and promoting health.The demand for orthodox medicine does not appear to be declining, but there may be an increase in the number of people searching for alternatives which are safer, more concerned with the personality and comfort of the individual, and directed more to helping people to live healthy lives.Systematic studies, whether of doctors working in general practice or in hospital, show that people want them to listen more carefully, to understand better their own beliefs and ways of thinking, to discuss and explain in language which
Hepatitis After γGlobulin
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Can states take the lead in health care reform?
Authors: M. Moon
Journal: JAMA (1992)

ENTHUSIASM for tackling problems with health care reform is not limited to the federal level. The slow pace of decision making at the federal level and the sense of crisis often surrounding states' Medicaid programs have helped to spur states into making their own plans. Several states already have implemented or sought to implement major changes in their health care systems. A number of other states have engaged in serious discussions about policy changes that could result in major reform of their health care systems. These options range from incremental approaches that tackle only a part of the issue to full-fledged proposals to put all health care under a single system at the state level. For example, the state of Hawaii has an employer mandate that has been in place since 1974. Oregon has captured the attention of many for one aspect of its health care plan—the explicit rationing that
Nutritional assessment
Authors: R. A. Wright
Journal: JAMA (1980)

THE AREA of nutrition has been neglected by the medical profession. Most medical schools devote less than three hours of total instruction to nutritional deficiency and therapy.<sup>1</sup>Only 3% of all questions on parts I, II, and III of the National Boards deal with the nutritional aspects of disease.<sup>1</sup>In short, physicians in the United States are not required to have any understanding of nutrition to be licensed to practice medicine. This situation is in striking contrast with increasing evidence that a large proportion of patients in our hospitals are malnourished. In 1976, Bistrian and coworkers<sup>2</sup>conducted three single-day nutritional surveys on patients in the general medical wards of the Boston City Hospital. By standard criteria more than 44% of the patients were malnourished, and the majority had definite signs of protein-calorie malnutrition. Willcutts, who assessed patients in a private community hospital, found 33% of the patients
The National Radium-223 Dichloride Audit group: Data from patients in UK oncology centers with metastatic castration-resistant prostate cancer treated with radium-223 dichloride.
Authors: Manreet Randhawa, Robert J Jones, Irene Stratton
Journal: Journal of Clinical Oncology (2019)

e16524 Background: Clinicians in 17 UK oncology centres comprise the National Radium-223 Dichloride Audit (NRDA) group which is evaluating treatment outcomes in patients with metastatic castration-resistant prostate cancer (mCRPC) treated with radium-223 dichloride (Xofigo). Methods: Patients commencing treatment from 1 st September 2017 were included. Clinical and laboratory parameters were collected throughout treatment. Analyses used frequency tables and univariate analysis. Results: As of February 2019, data from 400 patients has been collected. We report the outcomes on the first 150 patients who are evaluable. At first treatment, median age was 72 years (25 th to 75 th centile: 67-78), 54% of patients had an ECOG performance status (PS) of 1, 32.6% of patients had a WHO pain score of 1, 60% of patients had an ALP level of &lt; 220U/L and 26% of patients received docetaxel for mCRPC. The mean number of cycles completed was 5. Sixty patients (40%) did not complete 6 cycles and 42/60 (70%) discontinued due to disease progression. Changes in variables between treatment 1 and 6 are shown in Table. Adverse events reported were fatigue (76%), diarrhoea (38%), nausea/vomiting (35%), constipation (32%), anaemia (28%), thrombocytopaenia (12%) and neutropaenia (5%). There was no overall change in ECOG PS. In those who completed quality of life (QOL) questionnaires at treatment 1 and 6 (58%), there was no difference. Conclusions: The ongoing NRDA Group records data from mCRPC patients treated across the UK in routine care. To our knowledge, it is the first prospective analysis of such patients and the largest in assessing treatment patterns and outcomes including QOL data as well as standard laboratory parameters. Disclosures: The NRDA Group has been funded by a research grant from Bayer.[Table: see text]
Keyword Index - Volumes 59+60
Journal: Cardiovascular Research (2003)

Keyword Index -Volumes 59 + 60 Ablation (59) 668 Acetylcholine (59) 181, (59) 863, (59) 955 Actin translocating velocity (60) 580 Adenosine (59) 678, (60) 529 Adenovirus (59) 321, (60) 478 Adrenergic (59) 288 Adrenergic receptor (60) 598 Aging (59) 113 Angiogenesis (59) 479, (59) 997, (60) 664 Angiotensin (59) 200, (60) 413, (60) 547, (60) 557, (60) 589 Angiotensin converting enzyme (60) 131 Angiotensin-converting enzyme inhibitor (60) 447 Antiarrhythmic agents (59) 339, (60) 235, (60) 288 apoAI (59) 189 Apoptosis (59) 132, (59) 723, (59) 308, (59) 428, (59) 549, (60) 259, (60) 654 Arrhythmia (60) 510 Arrhythmia (mechanism) (60) 307 Arrhythmia (mechanisms) (59) 339, (59) 863, (59) 593, (59) 620, (59) 705, (60) 235 Arrhythmia therapy (60) 315 Arrhythmias (59) 612, (60) 288, (60) 337 Arterial hypertension (59) 549 Arteries (59) 573, (59) 997, (60) 58, (60) 205 Artherosclerosis (60) 68 Atherosclerosis (59) 189, (59) 734, (59) 776, (59) 988, (59) 234, (59) 241, (59) 479, (60) 58, (60) 165, (60) 198, (60) 205, (60) 259, (60) 626, (60) 664, (60) 673, (60) 684 ATPase activity (60) 580 Atrial fibrillation (60) 298, (60) 315 Atrial function (59) 360, (59) 863, (59) 593 Atrial vulnerability (60) 298 Beta-adrenergic desensitization (60) 478 Betablocker (60) 478 Biosensors (60) 388 Blood flow (59) 715, (59) 997, (60) 488 Blood pressure (60) 147, (60) 529 Ca-channel (60) 529 Calcium (59) 360, (59) 582, (59) 668, (60) 355, (60) 404 Calcium (cellular) (59) 46, (59) 369, (60) 337 Calcium current (59) 620 cAMP (60) 431 Ca-pump (59) 46, (59) 380, (59) 668 Cardiac biopsy (59) 400 Cardiac fibroblast (60) 365 Cardiac myocytes (60) 347 Cardiac myosin (60) 580 Cardiac remodeling (60) 538 Cardiomyocytes (59) 549 Cardiomyopathy (59) 57, (59) 400, (60) 87, (60) 376, (60) 388 Cardiotrophin (60) 365 Carvedilol (59) 776Ca 2+ -sensitive K + channels (60) 326 Cat papillary muscles (60) 589 Catenin (60) 376 cDNA array (59) 400 Cell adhesion (60) 376 Cell communication (59) 620, (59) 628, (60) 421, (60) 643 Cell culture/isolation (59) 883, (60) 438, (60) 497 Cellular (60) 288 Cellular communication (60) 288 cGMP (60) 268, (60) 431 cGMP-dependent protein kinase type I (60) 268 Chronic hypoxia (60) 326 Cocaine (59) 834 Collagen (60) 538 Collateral circulation (59) 573, (59) 997 Conduction (60) 288 Congenital defects (60) 165 Contractile apparatus (60) 388 Contractile function (59) 288, (59) 369, (59) 380, (59) 563, (59) 582, (59) 668, (60) 147, (60) 156, (60) 529 Contractility (60) 355 COPD (60) 326 Coronary blood flow (59) 745 Coronary circulation (59) 441, (59) 715, (60) 165 Coronary disease (59) 241, (59) 980, (60) 87, (60) 165 Cyclooxygenase-2 (60) 198 Cytokines (59) 241, (59) 776, (59)
The Surgical Treatment of Wounds and Obstruction of the Intestines.
Journal: JAMA (1891)

This little volume is the essay which received the Fiske Fund prize at the annual meeting of the Rhode Island Medical Society, held at Providence, June 12, 1890. The essay is divided into fourteen well-written chapters, which state in the best form the teachings of the day in regard to the subject. The authors also furnish a table of cases of cœliotomy for gun-shot wounds of the abdomen, and a careful summary of the tables. The chapters include the subjects of Intestinal Obstruction due to Congenital Malformations, Intussusception, Internal Strangulation, Volvulus, Obstruction from Foreign Bodies, Intestinal Paralysis, Chronic Obstruction and Peritonitis. There is a chapter on Diagnosis and on Wounds and Rupture. The tables are marred by bad proof-reading of the names of surgeons whose cases are quoted. Among the Americans thus pilloried we notice the following: W. S. Bull, instead of W. T. Bull, four out of five times;
Efficacy of BCG vaccine
Authors: G. W. Comstock
Journal: JAMA (1994)

<h3>To the Editor.</h3> —Dr Colditz and colleagues<sup>1</sup>have reviewed and digested an enormous amount of data in producing their meta-analysis of the efficacy of BCG vaccine in the prevention of TB. However, there are major considerations that cast doubt on their conclusions. Among these considerations is the implication in the title and the text that there is only one BCG vaccine. Numerous authors have called attention to the fact that the BCG vaccines produced in different laboratories vary in almost every measurable characteristic.<sup>2,3</sup>Variations might be expected to occur in a vaccine that had to be subcultured as often as every 2 weeks from its release in 1922 until freeze-dried strains were developed in the mid 1960s.<sup>4</sup>Strains have been found to differ in their survival on culture media, colony formation, viability, drug resistance, DNA restriction fragments, virulence in animals, anti-TB and antitumor protection in animals, production
Spark-generating properties of electrode gels used during defibrillation. A potential fire hazard
Authors: R. S. Hummel
Journal: JAMA (1988)

After a defibrillation attempt started a fire in an oxygen-enriched intensive care unit environment, seven popular electrode gels were tested for spark-generating properties by repeated 360-J electrical discharges into a 50-Ω test load. Gels with low initial impedance (7±1 Ω) allowed a high current flow (51 ±1 A), maintained a cool temperature (27°C to 33°C), and did not spark. Gels with high initial impedance (125 ±14 Ω) allowed less current (26 ±2 A), heated to 52°C±2°C, liquified, and generated an electrical spark after the fourth or fifth discharge. Federal standards should be developed to identify and label electrode gels that can be used safely for high-current applications such as defibrillation. (<i>JAMA</i>1988;260:3021-3024)
Staging laparotomy in early ovarian cancer
Authors: R. C. Young
Journal: JAMA (1983)

Systematic restaging was performed prospectively in 100 patients referred to the Ovarian Cancer Study Group institutions with a diagnosis of "early" (stage Ia-IIb) ovarian cancer. Before referral, only 25% of patients had an initial surgical incision that was adequate to allow complete examination of the pelvis and abdominal cavity. In patients referred to member institutions, 31 (31%) of 100 were found to have a more advanced stage and 23 (77%) of 31 of these actually had stage III disease. Sixty-one percent of the patients had their advanced stage detected by procedures other than a second laparotomy—nine (29%) of 31 by peritoneoscopy, six (19%) of 31 by peritoneal washings, and six (19%) of 31 by lymphangiography. Sites of unsuspected disease are most likely to be pelvic peritoneum, ascites fluid, other pelvic tissue, para-aortic nodes, and the diaphragms. Based on these data, we conclude that the initial staging approaches traditionally used in clinical evaluation of patients with early ovarian cancer are often incomplete and inadequate. (<i>JAMA</i>1983;250:3072-3076)
Women consultants
Authors: G Chamberlain
Journal: BMJ (1994)

disease must be considered.I became aware of an association between adult epiglottitis and malignancy when treating a patient with acute epiglottitis due to infection with Branhamela catarralis who was subsequently diagnosed as having acute myeloid leukaemia.'There have been other reports of acute epiglottitis in patients with leukaemia,3 and Lederman et al described seven cases of pneumococcal epiglottitis, six of which were associated with some form ofmalignancy.4Thus an underlying malignancy or other inmmunosuppressive disease5 should be suspected in cases of adult epiglottitis.This association may simply represent opportunistic infection occurring in immunocompromised patients and need not indicate a specific link.Assessment of the whole patient is, however, vitally important, even when the presenting symptoms and signs seem to be localised.
Correction: Health, Health Inequality, and Cost Impacts of Annual Increases in Tobacco Tax: Multistate Life Table Modeling in New Zealand
Authors: Tony Blakely, Linda J. Cobiac, Christine L. Cleghorn, Amber L. Pearson, Frederieke S. van der Deen, Giorgi Kvizhinadze, Nhung Nghiem, Melissa McLeod, Nick Wilson
Journal: PLoS Medicine (2016)

[This corrects the article DOI: 10.1371/journal.pmed.1001856.].