tbuckley/cabot-search huggingface dataset:
Older Adults’ Falls Take High Toll
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Multiple myeloma presenting high fever and high serum levels of lactic dehydrogenase, CRP, and interleukin‐6
Authors: Hirokazu Murakami, Satoru Takada, Nahoko Hatsumi, Akihiko Yokohama, Takayuki Saitoh, Hideki Uchiumi, Tadashi Maehara, Takafumi Matsushima, Norifumi Tsukamoto, Kimio Morita, Jun'ichi Tamura, Morio Sawamura, Masamitsu Karasawa
Journal: American Journal of Hematology (2000)

Two myeloma patients presented high fever with no signs or data indicating infection at diagnosis or relapse. Both patients had plasmablastic myeloma, and serum levels of lactic dehydrogenase (LDH) and CRP were extremely high. Plasmablastic morphology, high LDH, and CRP were recognized as poor prognostic factors, indicating a fulminant phase of multiple myeloma. Interleukin-6 (IL-6) was only high in measured cytokines. We proposed that IL-6 caused high fever and induced the fulminant phase in these 2 cases. Am. J. Hematol. 64:76–77, 2000. © 2000 Wiley-Liss, Inc.
Metabolism of human liver on a genome scale in non-alcoholic fatty liver disease
Authors: Parho Sen, Olivier Govaere, Aidan McGlinchey, Vlad Ratziu, Elisabetta Bugianesi, Jörn M. Schattenberg, Michael Allison, Simon Cockell, Ann K Daly, Tuulia Hyötyläinen, Quentin Anstee, Matej Orešič
Journal: Journal of Hepatology (2020)
Hospital Stays, Hospital Charges, and In-Hospital Deaths Among Infants With Selected Birth Defects—United States, 2003
Journal: JAMA (2007)

Birth defects (BDs) are conditions that 1) result from a malformation, deformation, or disruption in one or more parts of the body; 2) are present at birth; and 3) have a serious, adverse effect on health, development, or functional ability. BDs are leading causes of pediatric hospitalizations, medical expenditures, and infant mortality. To estimate national hospital charges and rates of in-hospital deaths for a greater number of specific BDs than estimated in previous reports, investigators at the University of Arkansas for Medical Sciences and CDC used the Healthcare Cost and Utilization Project 2003 Kids' Inpatient Database (KID), developed and distributed by the Agency for Healthcare Research and Quality. KID is a 10% sample of hospital discharges after uncomplicated births and an 80% sample of all other pediatric discharges from 36 participating states. Data are weighted to represent all pediatric hospitalizations in the United States. The investigators analyzed hospital stays during 2003 for newborn infants with any of 35 BDs. This report describes the results of that analysis, which indicated substantial variation among BDs regarding average length of stay, average hospital charge, and the incidence of in-hospital deaths. Average length of stay was greatest for infants with surgically repaired gastroschisis or omphalocele. Average hospital charges were highest for infants with hypoplastic left heart syndrome and common truncus arteriosus. Although anencephaly, trisomy 13, and trisomy 18 were associated with the highest rates of in-hospital death, the largest total numbers of deaths associated with neonatal hospitalizations occurred in infants with diaphragmatic hernia and renal agenesis. Further studies are needed to distinguish outcomes for infants with isolated and multiple defects and to assess longer-term outcomes.
Isolated systolic hypertension in the elderly. Some controversial issues
Authors: R. W. Gifford
Journal: JAMA (1982)

Although systolic hypertension in the elderly has received limited attention, it is associated with increased mortality and morbidity; it is not clear, however, whether it is the elevated blood pressure or the arteriosclerosis, for which it is a marker, that increases the risk. While there are no controlled, prospective trials confirming a reduction in morbidity and mortality with treatment, reduction of the systolic blood pressure will reduce the left ventricular work load, and in my opinion is indicated when the diagnosis of systolic hypertension is clearly established by multiple determinations. Contrary to the opinion of some, the elderly are able to tolerate antihypertensive drugs well when the drugs are administered cautiously in low dosages initially, with small increments. (<i>JAMA</i>1982;247:781-785)
Inferior vena cava obstruction in Whipple disease. Association with retroperitoneal lymphadenopathy
Authors: L. C. Maas
Journal: JAMA (1976)

WHIPPLE disease is an uncommon but treatable disorder that affects the small intestine and virtually any organ system of the body. Malabsorption, fever, arthritis, and generalized lymphadenopathy are frequently characteristic features. The purpose of this communication is to report an unusual presentation of the disease: massive retroperitoneal lymphadenopathy causing inferior vena cava obstruction. Further, the unusual histologic features of noncaseating granulomas within these lymph nodes suggested a sarcoid-like process until the results of a small intestinal biopsy confirmed the diagnosis of Whipple disease. <h3>Report of a Case</h3> A 60-year-old man entered Providence Hospital with urologic symptoms of frequency, nocturia, and dysuria. After routine examination, a transurethral resection of benign prostatic hypertrophic tissue was performed without event. During recovery, the patient told us of increasing edema of both legs and of foamy, foulsmelling stools occurring frequently over the past six months that had unexpectedly improved during short courses of antibiotic therapy
Neurology
Authors: R. J. Joynt
Journal: JAMA (1995)

Major advances in the molecular and genetic bases of neurological disease have continued to be the the major focus in the field of neurology. However, notable progress has been made in the prevention, diagnosis, and treatment of neurological disorders. Numerous clinical trials of various drugs and procedures are under way in patients with disorders long resistant to any therapeutic approaches. The vexing question of whether to operate in cases of asymptomatic internal carotid artery stenosis has been the subject of a large, randomized controlled clinical trial. The interim results of this trial were released in a National Institute of Neurologic Diseases and Stroke Clinical Advisory.<sup>1</sup>The conclusion was that carotid endarterectomy is beneficial for patients with asymptomatic carotid stenosis exceeding 60% of diameter reduction as confirmed by arteriography. Results were dependent on medical centers and surgeons who had a perioperative morbidity and mortality rate lower than 3%. Men had
THE PATHOLOGIC MECHANISM OF TREMOR.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical characteristics of renovascular hypertension
Authors: N. Simon
Journal: JAMA (1972)

Clinical characteristics of 175 patients with renovascular hypertension cured by surgery were compared with those of 339 patients with essential hypertension. Significant variables included abdominal or flank bruit, age, sex, race, duration and acceleration of hypertension, family history, symptoms, history of arterial occlusive disease outside of the kidney, body habitus, systolic blood pressure, orthostatic change in blood pressure, severity of retinopathy, cardiomegaly, blood urea nitrogen, serum creatinine and cholesterol levels, serum potassium and carbon dioxide contents, urinary casts, proteinuria, and bacteria. Some of the differences between the two populations were no longer apparent after matching 131 pairs of patients according to age, sex, race, and diastolic blood pressure. Patients cured by surgery were compared with patients who were improved, who failed to respond, and who had surgical deaths. In patients with atherosclerotic lesions, those who failed to respond had hypertension of longer duration and were more likely to show left ventricular hypertrophy than the cured patients. Those with surgical death had more widespread atherosclerosis, cardiac damage, and renal functional impairment.
Correction: A mantle of safety: the 50th year of the Royal Flying Doctor Service
Journal: BMJ (1979)

charge.He already exercises this authority over optometrists, whose fees now attract insurance rebates.If the GP Society's constitutional challenge fails, the way might be open to govern- ment control of every branch of the profession.Recent AMA moves to limit foreign graduates entering the country and the number of new Australian graduates may be agreed to by government.After years of a doctor "shortage" now that there is a possibility of a "surplus" the AMA fears for the economic viability of its members.A vigorous challenge has been launched by the GP Society, arguing that the mere possession of an MB parchment is no guarantee of any right to earn a living in the market place; competition can lead only to higher standards and perhaps to some stabilisation of fees.The AMA's moves parallel those in Canada, where it is being suggested that not only should the numbers of immigrant doctors and new graduates be cut down but that all doctors should mandatorily retire at 60.
Breast cancer in Irish families with Lynch syndrome.
Authors: E. J. Jordan, M. P. Farrell, R. M. Clarke, M. R. Kell, J. A. McCaffrey, E. M. Connolly, T. Boyle, M. J. Kennedy, P. J. Morrison, D. J. Gallagher
Journal: Journal of Clinical Oncology (2012)

413 Background: Breast cancer is not a recognised malignant manifestation of Lynch Syndrome which includes colorectal, endometrial, gastric, ovarian and upper urinary tract tumours. In this study we report the prevalence of breast cancer in Irish Lynch Syndrome families and determine immunohistochemical expression of mismatch repair proteins (MMR) in available breast cancer tissue. Methods: Breast cancer prevalence was determined among Lynch Syndrome kindreds from two institutions in Ireland, and a genotype phenotype correlation was investigated. One kindred was omitted due to the presence of a biallelic MMR and BRCA1 mutation. The clinicopathological data that was collected on breast cancer cases included age of onset, morphology, and hormone receptor status. Immunohistochemical staining was performed for MLH1, MSH2, MSH6, and PMS2 on all available breast cancer tissue from affected individuals. Results: The distribution of MMR mutations seen in 16 pedigrees was as follows; MLH1 (n=5), MSH2 (7), MSH6 (3), PMS2 (1). Sixty cases of colorectal cancer and 14 cases of endometrial cancer were seen. Seven breast cancers (5 invasive ductal and 2 invasive lobular cancers) and 1 case of ductal carcinoma in situ were reported in 7 pedigrees. This compared with 4 cases of prostate cancer. Six MSH2 mutations and 1 MSH6 mutation were identified in the 7 Lynch syndrome kindreds. Median age of breast cancer diagnosis was 49 years (range 38-57). Hormone receptor status is available on 3 breast cancer cases at time of abstract submission; all were ER positive and HER 2 negative. All cases had grade 2 or 3 tumours. Final results of immunohistochemistry for mismatch repair protein expression on breast cancer samples are pending and will be reported at the meeting. One breast cancer has been tested to date and demonstrated loss of MSH2 protein expression in an individual carrying an MSH2 mutation. Conclusions: Breast cancer occurred at an early age and was more common than prostate cancer in Irish Lynch Syndrome pedigrees. All reported breast cancer cases were in kindreds with MSH2 or MSH6 mutations. Enhanced breast cancer screening may be warranted in certain Lynch Syndrome kindreds.
Sterile needles: human immunodeficiency virus in diabetic intravenous drug users
Authors: D. Fernando
Journal: JAMA (1992)

<h3>In Reply.</h3> —We thank Dr Fernando for his observations and comments concerning our study, in which we found a significantly lower prevalence of HIV infection among diabetic (9.8%) than non-diabetic (24.3%) IVDUs in Baltimore, Md. There was only one plausible explanation for the substantially lower rate of HIV infection among diabetic IVDUs in our study, namely, that the diabetics more regularly used sterile drug injection equipment. Safer injection practices among diabetics are possible precisely because they are not likely to be prosecuted for violation of "paraphernalia laws" for possession of drug injection equipment. As pointed out by Dr Fernando, the possession of drug injection paraphernalia is now a criminal offense nearly everywhere in the United States. We agree that the use of contaminated injection equipment by drug users is usually not an act of cultural solidarity but rather a behavioral strategy to avoid arrest and imprisonment, while suffering from drug
A MODIFICATION OF HALL'S ANAEROBIC CULTURE TUBE
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ON REDUCTION OF DISLOCATIONS BY MANIPULATION.
Authors: M M Louis Hutchinson
Journal: JAMA (1884)

April22, 1884. <h3>Sir:</h3> —In reading the last edition of yourJournal, I was not a little surprised at your reference to my communication on the above-named subject, and I now trust that in a spirit of fairness you will give equal publicity to my reply. You have asserted that one of your motives for inserting my communication was to make it the occasion of correcting my erroneous views concerning the status of surgical progress in this country. In such a case, I think that your comments should have appeared in the same number of theJournal, together with the article commented upon—whereas they failed to appear until two weeks afterwards—and this, to say the least, was somewhat lacking in courtesy, and entirely at variance with editorial custom. In stating that manipulation was but little taught in schools, I based my belief on the information of several medical men here,
Onchocerciasis
Authors: Daniel H. Connor
Journal: New England Journal of Medicine (1978)

ONCHOCERCIASIS, a filarial infection transmitted by black flies, has taken its toll of countless generations of Africans. Today, it afflicts 40 million and has blinded between one-quarter and one-half million persons. The regional prevalence and severity vary greatly, but in many regions, the people are resigned and accept the blindness and dermatitis as processes of aging. Although the blindness is devastating, the incessant pruritus that characterizes the dermatitis can be just as unfortunate by preventing sleep and productive work. In addition to inflicting personal misery, onchocerciasis has driven communities away from streams and rivers and from rich lands that offer . . .
Ethical dilemmas for house staff physicians. The care of critically ill and dying patients
Authors: W. Winkenwerder
Journal: JAMA (1985)

THE LIFE-SUSTAINING capability of modern medicine, coupled with its difficult ethical choices, has become the physician's most challenging moral dilemma<sup>1-5</sup>(<i>US News and World Report</i>, Dec 6, 1982, p 53;<i>Time</i>, April 9, 1984, p 68). Caring for critically ill and dying patients is a difficult task that often vacillates between the rational and the absurd, the uplifting and the morbid. Conflicts in values among caretakers are frequently present, and uncertainty is pervasive. This article addresses the issue of distinctive ethical dilemmas faced by residents in caring for critically ill and dying patients, a problem that springs from the increasing capabilities of medicine and the peculiar role of residents in our medical hierarchy. Residents are fully licensed to practice medicine, but they are not totally autonomous. They have heavy responsibilities in patients' care, but they are not independent in making many decisions. They are usually the primary caretakers, but
In Vivo X-Ray Fluorescence of Lead in Bone: Review and Current Issues
Authors: Andrew C. Todd, David R. Chettle
Journal: Environmental Health Perspectives (1994)

Bone lead measurements can assess long-term lead dosimetry because the residence time of lead in bone is long. Bone lead measurements thus complement blood and plasma lead measurements, which reflect more short-term exposure. Although the noninvasive, in vivo measurement of lead in bone by X-ray fluorescence (XRF) has been under development since the 1970s, its use is still largely confined to research institutions. There are three principal methods used that vary both in the how lead X-rays are fluoresced and in which lead X-rays are fluoresced. Several groups have reported the independent development of in vivo measurement systems, the majority adopting the 109Cd K XRF method because of its advantages: a robust measurement, a lower detection limit (compared to 57Co K XRF), and a lower effective (radiation) dose (compared to L XRF) when calculated according to the most recent guidelines. These advantages, and the subsequent widespread adoption of the 109Cd method, are primarily consequences of the physics principles of the technique. This paper presents an explanation of the principles of XRF, a description of the practical measurement systems, a review of the human bone lead studies performed to date; and a discussion of some issues surrounding future application of the methods.
Greene County Boys Sing For Scholarships
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 61: Anti-inflammatory Effect Of Resveratrol In Human Coronary Arterial Endothelial Cells Via Autophagy: Implication For The Treatment Of Kawasaki Disease
Authors: Fu-Chen Huang Huang, Ho-Chang Kuo, Hong-Ren Yu
Journal: Circulation (2015)

Kawasaki disease (KD) is an acute febrile vasculitis of childhood and is the leading cause of acquired heart disease in children in the developed world. If untreated, KD can result in coronary aneurysms in 25% of patients, who are at risk of myocardial infarction, sudden death, and congestive heart failure. Despite the success, 10-20% of children will have persistent or recrudescent fever after their first infusion of IVIG. These patients are at increased risk of developing coronary artery abnormalities. Additional therapies should be explored to decrease the incidence of coronary arteritis complication and improve the prognosis in Kawasaki disease. Induced autophagy with resveratrol confers cardioprotection during ischemia and reperfusion in rats. KD is associated with elevated production of inflammatory cytokines, causing damage to the coronary arteries. Serum TNF-alpha levels are elevated in KD, which was supposed to activate the endothelial cells. As a result, adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1) and vascular cellular adhesion molecule-1(VCAM-1) are expressed in the endothelial cells, and leucocytes adhere firmly to endothelial cells. The leucocytes then damage the endothelial cells and smooth muscle cells and cause vasculitis. In this study, we examined the anti-inflammatory effects of resveratrol on TNF-alpha-induced adhesion molecule expression (VCAM-1 and ICAM-1) and cytokine production (interleukin (IL)-1beta, IL-6 and IL-8) in HCAECs. Pretreatment with resveratrol significantly inhibited TNF-alpha-induced adhesion molecules and cytokines production in HCAECs via the activation of autophagy. Our results suggest that adjunctive resveratrol therapy may modulate the inflammatory response during KD vasculitis and explore the role of autophagy in the pathogenesis of the complication and the promising therapy.