tbuckley/cabot-search huggingface dataset:
Strategies for Epidemiologic Studies of Lead in Bone in Occupationally Exposed Populations
Authors: Phillip J. Landrigan
Journal: Environmental Health Perspectives (1991)

Lead exposure is widespread among industrial populations in the United States. X-ray fluorescence (XRF) analysis of the lead content of bone offers a promising approach to acquisition of individualized data on chronic lead absorption in occupationally exposed populations. Dosimetric data obtained by XRF will permit accurate definition of dose-response relationships for such chronic consequences of lead exposure as central and peripheral neurologic impairment, renal disease. hypertension, and possibility reproductive dysfunction. Additionally, data on bone lead content obtained by XRF will permit validation of models describing the body lead burden and will allow direct assessment of the efficacy of therapeutic chelation. XRF data may also permit assessment of the possible role of genetic polymorphism of the enzyme delta-aminolevulinic dehydrase as a determinant of the pharmacokinetics and toxicity of lead. In both cross-sectional and prospective epidemiologic studies of body lead burden in occupationally exposed populations, the K-XRF instrument appears to be the technology of choice.
Dr Wallaby
Authors: Anthony L. Rostain
Journal: JAMA (1985)

YESTERDAY afternoon, just after I had finished with my last patient, a man burst into my office. Gasping for breath, he pleaded, "This is an emergency! Please see me immediately!" Before I could reply, he collapsed into my chair and began his tale of woe. "My name is William Wallaby. I'm a 45-year-old internist, and I'm sick. I don't sleep well. I can't concentrate anymore. Worst of all, I'm really starting to doubt my skills as a doctor." Dr Wallaby's only other complaints were headaches and low back pain. However, he admitted to overeating, cigarette smoking, and ocassionally excessive drinking. He exercised rarely, spent little time with his family, and almost never saw his friends. Suspecting that Dr Wallaby was depressed because of his work, I asked him to tell me about his life as a doctor. "After I graduated from medical school," he replied, "I did my time in
Hunterian Lectures ON MAN'S POSTURE: ITS EVOLUTION AND DISORDERS: Given at the Royal College of Surgeons of England
Authors: A. Keith
Journal: BMJ (1923)

patient learns this the addiction becomes confirmed and of the most serious character.The other cocaine-like substances which might lead to habit are stovraine, tropacocaine, and perhaps holocaine, tbough cases of addiction to these are unknownto me.To some extent fashion or opportunity determines the type of drug used.In New York heroin is used almost entirely, in Chicago morphine is the common narcotic, and in cities with a large coloured population cocaine is in vogue. TREATMENT.The first and principal fact to remember in treatment is that the addict is not a mentally normal man, and the problem is not so much whether we can temporarily stop the addiction as wbether we can educate his mind so that temptation can be ,withstood-in other words, to alter his clharacter.Simply to .controlconduct so that choice cannot be exerted is to court disaster.The following examples will show the effect of custodial care alone.The Department of Health of the City of New York publishes statistics and details by medical experts of nearly 8,000 cases-of drug addicts during ten months;-1,580'received at. the clinic were willing to accept treatment and withdrawal of the drug.Those-treated were kept six weeks and dis- charged -in good plhysical condition' " cured.".' In'.three months a large proportion had already relapsed, in spite of all efforts made to assist them.Dr. Doane, speaking in November, 1920, stated that there lhad been treated -in the Philadelphia Hospital 3,500 cases of drug addiction, four-fifths of which were heroin and cocaine.These pattents were mostly from the lower strata of society.Dr. Doane thought that 3,400 or 3,500 bad relapsed.In Los Angeles the Board of Health, with the assistance of the municipal authorities, started a narcotic clinic where addicts got their supply at a nominal price witlhout criminal risk.-This system had several advantages: the victims were able to work again; illicit peddling was reduced to a minimum; thie addicts became known; but the system was much abused and cures were not effected.It is generally recognized that of all addicts those that con- tract tlhe lhabit as a result of disease are easiest to cure.All addicts desire to be cured but fear tlle withdrawal symptoms.An addict may beg to 'give up the habit of his' own free will and submit to restraint, but as soon as his wishe3 are acceded to he will endeavour to render restraint unavailina, and lie is so well versed in the literature of the subject that he finds a ready reason for anything he does.'He is quite unable to resist an opportunity to clheat if the occasion offers.To ensure even a temporary cure restraint and custodial care are thletefore essential,The 'chief reason against restraint is that our object is not so machl the temporary suppression of the morplhine as the cure of the desire for it, and the best way of effecting this is by he re-education of the dormant will.Under restraint the drug can be gradually reduced, and generally ten days will suffice 'to bring it down to nil.Some
Abstract 817: Assessment and manipulation of DNA methylation in cancer cells using terahertz radiation
Authors: Hee-Jin Yang, Hwayeong Cheon, Jin Ho Paik, Joo-Hiuk Son
Journal: Cancer Research (2019)

Carcinogenesis is closely associated with abnormal regulation of gene expression, among which DNA methylation in one of the key epigenetic modifications. Therefore, several studies have been directed towards the evaluation of DNA methylation. Here, we aimed to experimentally observe the specific signal of methylated DNA in various blood cancer cell lines using terahertz (THz) radiation, which is presented as a resonance in the spectrum. THz radiations are electromagnetic waves having frequencies of 0.1−10 THz, which falls between those of infrared radiation and microwaves. Molecular low-energy motions in THz region, such as collective vibrations, torsion of molecular structures, and hydrogen bonds, is correlated with biological characteristics, i.e., vibrational modes of DNA, structural modes in proteins, cell membrane vibrations, or enzyme activity. These features are usually presented as a characteristic resonance of the modes in the THz spectrum. In our study, the degree of global DNA methylation was obtained by the quantification of the resonance around 1.7 THz, and the results were in good agreement with those obtained by enzyme-linked immunosorbent assay (ELISA). Further, DNA demethylation was performed using high-power THz radiation around the resonance frequency of 1.7 THz, which lead to a 10% to 72% decrease in the degree of DNA methylation as shown in Table 1. Thus, our data shows the feasibility of using THz radiation for the assessment and manipulation of DNA methylation. This is the first study wherein the sensing and manipulation of DNA methylation could be achieved using a non-contact and non-invasive optical technique. Use of THz radiation for the assessment of DNA methylation might be helpful for its rapid processing, while THz manipulation of DNA methylation can avoid the toxicity of chemical demethylating agents. We propose that THz radiation may be useful for the diagnosis of cancer and we expect that THz demethylation might find potential application in cancer therapy.Change of methylation status of blood cancer DNA using high-power THz radiation.SamplesNo ExposureHigh-power THz exxpsoureChange (%) THzChange (%) ELISATHzELISARatio1THzELISARatio2119.621.8510.6111.661.0611.0040.5742.70211.341.388.2210.201.198.5710.0513.77315.151.4310.596.240.738.5558.8148.95417.731.4712.063.510.447.9880.2070.07511.271.437.8810.001.367.3511.274.90STDEV1.58STDEV1.24THz, the amplitude of terahertz resonance; ELISA, optical density of Enzyme linked immunosorbent assay; STDEV, standard deviation1 THz/ELISA of no exposure2 THz/ELISA of high-power THz exposureCitation Format: Hee-Jin Yang, Hwayeong Cheon, Jin Ho Paik, Joo-Hiuk Son. Assessment and manipulation of DNA methylation in cancer cells using terahertz radiation [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 817.
A Mendelian Predisposition to B Cell Lymphoma Caused by IL-10R2 Deficiency
Authors: Benedicte Neven, Emilie Mamessier, Julie Bruneau, Sophie Kaltenbach, Felipe Suarez, Francois Doz, Daniel Orbach, Veronique Minard, Pierre Frange, Danielle Canioni, Isabelle Radford-Weiss, Vahid Asnafi, jean-Laurent Casanova, Stephane Blanche, Capucine Picard, Frederic Rieux-Laucat, Frederic Davi, Nicole Brousse, Bertrand Nadel, Frank Ruemmele, Alain Fischer
Journal: Blood (2012)
Urology
Authors: M S Litwin
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Genomic Analysis, Surgical Treatment and Outcomes of Lower-Grade Gliomas in a Single Institution
Authors: David Eagle, Anca Merla, Shungu O Ushewokunze, David Jellinek, Hesham Zaki, Stephen Wharton, Fiona Mckevitt
Journal: Neuro-Oncology (2018)

Recent research has demonstrated that IDH and 1p/19q status in lower grade tumours better predicts clinical outcome than histological class. We reviewed our institutional outcomes based on these parameters combined with the addition of the outcomes of biopsy versus resection. Design A 10-year retrospective case review analysing histological grade and genetics of tumour specimens, surgical treatment and resulting clinical outcomes. Patients undergoing biopsy or resection of lower grade gliomas between 2005 and 2016 in our institution. Cases were identified from histology database records. Data was then collected using case notes, operation reports and PACS. 147 patients underwent sampling of a tumour on which genetic analysis was performed. 48 had biopsy alone, 99 underwent resection. Histologically 63 cases were classified as Grade II, 84 as Grade III. IDH mutation was present in 74, of which 84% survive, and negative in 41 of which 49% survive giving a RR of 1.53 (p-value 0.0002). Classic 1p/19q co-deletion was present in 41 of which 78% survive, and absent in 69, of which 72% survive giving an insignificant (p-value 0.1695) increased survival of 1.18. To date our outcomes appear to be consistent with those published in the literature. Genetic analysis of historical samples is important to understand the behaviour of lower grade gliomas.
Extramedullary Plasmocytoma
Authors: B. Rowlands, N. Shaw
Journal: BMJ (1954)

often been surprisingly mild and have been disproportionate to the degree of cerebral disturbance seen during life.It is suggested that, to some extent, the severity of the illness may be assessed by observing the mode of onset, the depth and duration of unconsciousness, the fre- quency of convulsions, and the persistence of signs indicating focal damage of the brain.I am indebted to Professor Sir James Spence for much help
Cigarette Smoking Among Reproductive-Aged Women—Behavioral Risk Factor Surveillance System, 1989
Journal: JAMA (1991)

Women who smoke cigarettes are at increased risk not only for chronic diseases (e.g., lung cancer and chronic obstructive pulmonary disease) but--if they use oral contraceptives--also for myocardial infarction (1). In addition, cigarette smoking during pregnancy increases the risk for low birth weight and premature infants, miscarriage, stillbirth, sudden infant death syndrome, and infant mortality (2). Because of these risks and other health problems associated with cigarette smoking, one of the national health objectives for the year 2000 is to reduce the prevalence of smoking to 12% among reproductive-aged women (18-44 years of age) (3). This report summarizes data from the 1989 Behavioral Risk Factor Surveillance System (BRFSS) on the prevalence of smoking among reproductive-aged women.
WASHINGTON NEWS
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Accession of Carlos
Journal: JAMA (1978)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Book Reviews
Authors: William W. Weddington, Nikolas Manos, George Mendelson, H. Teshima, C. Kubo, H. Kihara, Y. Imada, S. Nagata, Y. Ago, Y. Ikemi, Donna Lou Udelman, Robert J. Feiguine, Deborah M. Hulihan, Robert A. Kinsman, Nicholas A. Covino, Jerald F. Dirks, Robert A. Kinsman, John V. Seidel
Journal: Psychotherapy and Psychosomatics (1982)
Correction: Lack of Mucosal Immune Reconstitution during Prolonged Treatment of Acute and Early HIV-1 Infection
Authors: Saurabh Mehandru, Michael A Poles, Klara Tenner-Racz, Patrick Jean-Pierre, Victoria Manuelli, Peter Lopez, Anita Shet, Andrea Low, Hiroshi Mohri, Daniel Boden, Paul Racz, Martin Markowitz
Journal: PLoS Medicine (2006)
A CORRECTION.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
COIFFURE KELOIDS
Authors: MARGARET A. H. BAYLES
Journal: British Journal of Dermatology (1972)

Journal Article COIFFURE KELOIDS Get access MARGARET A. H. BAYLES MARGARET A. H. BAYLES Department of Dermatology, King Edward VIII Hospital, Durban, Natal, South Africa Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 86, Issue 4, 1 April 1972, Page 415, https://doi.org/10.1111/j.1365-2133.1972.tb05056.x Published: 01 April 1972 Article history Accepted: 30 November 1971 Published: 01 April 1972
Deglutition syncope.
Authors: B Wik, L Hillestad
Journal: BMJ (1975)

avidly protein bound persists in the tissues.We could not implicate the subcutaneous injection techniques in the patients (Cases 3-9) who developed indurated pruritic transient lesions within hours of injection.Contact sensitization to cresols is recognized,5 and we suspect that all local and one of the systemic reactions seen in our patients resulted from hypersensitivity to the chlorocresol preservative.Intradermal skin testing with chlorocresol-preserved heparin gave immediate responses, whereas in only one (Case 1) of the tests with preservativefree heparin (Weddel) was there a reaction.We suggest that in cases of apparent heparin sensitivity treatment may be able to continue without adverse reaction after cautious challenge with chlorocresol-free heparin.We are grateful to
MSG
Authors: June Reaume
Journal: JAMA (1975)

<h3>To the Editor.—</h3> A letter by Dr. Linda Bartoshuk and colleagues (230:670, 1974) described a taste panel test in which 34 Yale undergraduates used monosodium glutamate (MSG) vs table salt (NaCl) in tomato juice to make the juice as palatable as possible. It appears that this study ignored the fact that MSG is considered to be a flavor potentiator,<i>not</i>a salt substitute. Due to its synergistic action, MSG augments the flavor effects of salt and other components in a food product thereby enhancing the blend and leading to full-bodied flavor. While sodium intake was the concern of the investigators in this study, MSG was used without discretion or consideration of current label recommendations. For a number of years we have directed our efforts to the training of flavor analysts who ultimately provide objective, analytical descriptions of the flavor of a product in terms of the contribution of individual components
Twenty four hour care in inner cities.
Journal: BMJ (1989)

during the first vear.TFhe ouitpatient waiting time stands at two weeks, and sincc it opened the waiting time at the longer established unit has declined steadilI to an average of three months.We believe that providing adequate facilities of this type is a much more satisfactory solution to the problem of delays in fitting hearing aids than the proposal suggested in the Royal National Institute for the Deaf document entitled Hearing Aids -The Case for Change.
SEASICKNESS
Authors: P. H. DESNOES
Journal: JAMA (1926)

This study of seasickness is based on a review of the medical literature on the subject and on personal observation. It also embodies the collective experience of the ships' doctors, who have been in the service for from two to ten years on ten of our passenger steamers of the New York division. The history of this affliction is of ancient origin. Among the early Greeks it was well known, and they attached great therapeutic value to a moderately severe attack of mal de mer.<sup>1</sup>The immediate cause of seasickness is the oscillation of the ship about its various axes due to the action of the waves and to the ground swell. To this constant rise and fall, pitch and roll, is added a secondary minor factor, the fine, unremitting tremor and vibration transmitted from the engines throughout the framework and superstructure of the vessel. (In large motor ships the
Adrenal Steroids in the Treatment of Idiopathic Nephrotic Syndrome in Adults
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Expert medical testimony
Authors: C. D. Aring
Journal: JAMA (1976)

BURTON L. Wise<sup>1</sup>has noted the need to restructure the testimony of expert medical witnesses in courts of law in the United States. The main change proposed is that experts testify as unbiased witnesses reporting to the court, the material to be used by one or both sides as they see fit. This proposal is so obviously reasonable and equitable that it is a wonder it has not been pursued wherever civilization is improving. It is a question with which I have been concerned during my entire career. Shortly after finishing postgraduate training in neurology and psychiatry, I was among those instrumental in founding a local society of neurology and psychiatry. Discomfited by the beating that truth was taking in courts of law, to say nothing of the humiliation of the profession and especially psychiatry in the press, several of us drew up a resolution to embody the very