tbuckley/cabot-search huggingface dataset:
NIMG-43. RADIOLOGICAL CHARACTERISTICS AND NATURAL HISTORY OF ADULT IDH WILD-TYPE ASTROCYTOMAS WITH TERT PROMOTER MUTATIONS
Authors: Cristina Izquierdo, Marc Barritault, Delphine Poncet, Stéphanie Cartalat, Bastien Joubert, Jordi Bruna, Emmanuel Jouanneau, Jacques Guyotat, Alexandre Vasiljevic, Tanguy Fenouil, Yves Berthezène, Jerôme Honnorat, David Meyronet, François Ducray
Journal: Neuro-Oncology (2018)

Adult IDH-wildtype astrocytomas with TERT promoter mutations (TERTp) are associated with a poor prognosis. The aim of the present study was to analyze their radiological presentation and natural history. We retrospectively reviewed the characteristics of 40 IDH-wildtype TERTp-mutant astrocytomas (grade II n=19, grade III n=21) and compared them to those of 114 IDH-mutant lower grade gliomas (LGG), of 92 IDH-wildtype TERTp-mutant glioblastomas and of 15 IDH-wildtype TERTp-wildtype astrocytomas. Most cases of IDH-wildtype TERTp-mutant astrocytomas occurred in patients aged >50 years (88%) and presented as infiltrative lesions without contrast enhancement (73%) that were localized in the temporal and/or insular lobes (37.5%) or corresponded to a gliomatosis cerebri (43%). Thalamic involvement (33%) and extension to the brainstem (27%) were frequently observed, as was gyriform infiltration (33%). This radiological presentation was different from that of IDH-mutant LGG, IDH-wildtype TERTp-mutant glioblastomas, and IDH-wildtype TERTp-wildtype astrocytomas. Tumor evolution before treatment initiation was assessable in 17 cases. Ten cases demonstrated a rapid growth characterized by the apparition of a ring-like contrast enhancement and/or a median velocity of diametric expansion (VDE) 8 mm/year but 7 cases displayed a slow growth (VDE < 8 mm/year) that could last several years before anaplastic transformation. Median overall survival of IDH-wildtype TERTp-mutant astrocytomas was 27 months. IDH-wildtype TERTp-mutant astrocytomas typically present as non-enhancing temporo-insular infiltrative lesions or as gliomatosis cerebri in patients aged >50 years. In the absence of treatment, although rapid tumor growth is frequent, an initial falsely reassuring, slow growth can be observed.
Vitamin E and Respiratory Tract Infections in Elderly Nursing Home Residents—Correction
Authors: Stephen Piwinski, Ajit Singh Kashyap, Kuldip Parkash Anand, Surekha Kashyap
Journal: JAMA (2004)

To the Editor: Using Ranson's criteria to forecast outcome in patients with pancreatitis would indicate that a 56-year-old individual with a glucose level of 201 mg/dL (11.2 mmol/L) and a white blood cell count of 16.1 ϫ10 3 /µL has the same risk for adverse outcome as one who develops a PO 2 of less than 60 mm Hg, has a decrease in hematocrit by 10%, and sequesters 6 L of abdominal fluid in 48 hours. 1 I would call into question the validity of a scoring system that equally weights these disparate factors.An important article by Ranson and Pasternack 2 used versions of stepwise regression analysis to search for the criteria most predictive of acute pancreatitis.In this article, the 11 variables of Ranson were not equivalent in predictive value.Elevated lactate dehydrogenase and aspartate aminotransferase in the several tested models had the greatest prognostic capability. 2 I consider lactate dehydrogenase and aspartate aminotransferase to be covariates indicative of liver disease and think Ranson's studies show that patients with unhealthy livers and pancreatitis are more likely to have poor outcomes.I believe the prognostic system proposed by Rabeneck et al 3 to be a better and simpler tool, relying on the presence or absence of ileus in association with comorbidities to forecast outcome.I suggest that a continued endorsement of Ranson's criteria seems out of place.
Smoking, oral contraceptives, and obesity. Effects on white blood cell count
Authors: I. R. Fisch
Journal: JAMA (1975)

Data from 14,961 healthy women were analyzed to determine the relative importance of factors that alter the white blood cell (WBC) count. The effects of smoking, oral contraceptive use, and obesity were most striking. A total leukocyte count greater than 10,000/cu mm was found in 44% of obese, heavily smoking women who took oral contraceptives (central 95% of the distribution was 5,800 to 14,200/cu mm) as compared to 2% of women without these attributes (3,500 to 9,400/cu mm). Other factors such as age, time of day, phase of the menstrual cycle, and red blood cell variables were of lesser significance. The use of noncontraceptive estrogenic hormones did not affect the WBC count. Recognition of these findings is important because excessive laboratory studies, lost physician time, and patient inconvenience may thereby be avoided. (<i>JAMA</i>234:500-506, 1975)
Study of the Coal-Tar Pitch, with Special Regard to Its Epithelioma-Producing Factor.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
NEW YORK CANCER STATISTICS.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pleural Biopsy
Authors: I. Alfred Breckler, Milton C. Hoffman, Harry E. Hill, Nestor M. Hensler, Peter B. Hukill
Journal: New England Journal of Medicine (1956)

IN 1953 Sutliff, Hughes and Rice1 reported a series of 21 cases of pleural disease presenting various problems of management and diagnosis. Pleural biopsy in 17 cases showed granulomatous disease of the pleura compatible with the diagnosis of tuberculosis. Three cases showed neoplastic invasion of the pleura, and in 1 case yeast organisms identified as agents of North American blastomycosis were found. No mention was made whether these were consecutive cases or whether they were selected cases showing positive findings. The technic was one of open pleural biopsy. A portion of rib was resected, and the pleura exposed through an . . .
A Leap-Year Birthday
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE PUBLIC PRESS AND THE PHYSICIANS.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TOLBUTAMIDE IN NONDIABETIC DISORDERS
Journal: JAMA (1960)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Night and Day
Authors: Eric J. Warm
Journal: Annals of Internal Medicine (2003)

On Being a Doctor15 April 2003Night and DayEric J. Warm, MDEric J. Warm, MDFrom University of Cincinnati; Cincinnati, OH 45267-0535.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-138-8-200304150-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The morning report room smelled like chicken tikka masala, pizza, and sweat. I cleared off several cardboard cartons from the table, sat down next to the chief resident, and gave her my team census.I see you've been eating well, she said. How was your night?How was my night?The usual stuff, really. After the other residents had gone I became the senior most physician in charge of the headaches, heartaches, dyspneas, decubiti, fevers, and falls of the day. Not bad for a second-year resident in December. At 8:00 p.m. my pager sounded; 4 South wanted me.Are you ... Author, Article, and Disclosure InformationAffiliations: From University of Cincinnati; Cincinnati, OH 45267-0535.Corresponding Author: Eric J. Warm, MD, 231 Albert Sabin Way, PO Box 670535, Cincinnati, OH 45267-0535; e-mail, [email protected]edu. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 April 2003Volume 138, Issue 8Page: 683-684KeywordsChartsNursesPatient advocacyResidencyRibsShouldersSodiumSweatThoraxWalking ePublished: 15 April 2003 Issue Published: 15 April 2003 Copyright & PermissionsCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Sequences And Factors: A Guide To Mhc Class-Ii Transcription
Authors: L. Glimcher
Journal: Annual Review of Immunology (1992)

The expression of the class-II antigens of the major histocompatibility complex is tissue-specific, developmentally regulated in cells of the B lineage, and inducible by cytokine. Some of the molecular mechanisms that account for this regulation have recently been elucidated. DNA sequences upstream of human and mouse class-II genes that are critical for the transcription of these genes have been identified through transfection studies and transgenic analysis. Furthermore, a number of transcription factors that bind to important promoter motifs have recently been isolated. Examination of the class-II promoter in vivo both in the normal state and in patients with bare lymphocyte syndrome has further increased our understanding of class-II regulation.
BOOK REVIEWS
Authors: M. TSOKOS
Journal: JNCI Journal of the National Cancer Institute (1988)

Journal Article BOOK REVIEWS Get access Pathology of Human Neoplasms: An Atlas of Diagnostic Electron Microscopy and Immunohistochemistry. Henry A. Azar, ed., New York: Raven Press, 1988, 638 pp. $99.00 MARIA TSOKOS MARIA TSOKOS Ultrastructural Pathology Section, Division of Cancer Biology and Diagnosis, National Cancer Institute, Bldg.10, Rm. 2A-10, National Institutes of HealthBethesda, MD 20892 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 80, Issue 20, 21 December 1988, Pages 1638–1639, https://doi.org/10.1093/jnci/80.20.1638 Published: 21 December 1988
Advertisements.
Journal: JAMA (1883)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SWITZERLAND
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reply
Authors: Elsa Solà, Sabela Lens, Mónica Guevara, Pere Ginès
Journal: Hepatology (2010)

We thank Dr. Krag and colleagues for their comments on our article on hyponatremia in patients treated with terlipressin for severe gastrointestinal bleeding due to portal hypertension.1 We believe that the most important pathogenic factor in the development of a decrease in serum sodium concentration in patients with gastrointestinal bleeding treated with terlipressin is a reduction in solute-free water clearance due to the effect of terlipressin on V2 receptors located in the collecting duct cells, as nicely demonstrated by the same authors in a recent study.2 Nevertheless, an increased natriuresis can also participate. With respect to the duration of treatment with terlipressin, the 2010 Baveno Consensus Conference on Portal Hypertension indicates that pharmacological treatment of acute variceal bleeding should be maintained for 5 days.3 However, in response to the comment of Krag et al., suggesting a shorter duration of therapy (of only 2 days), we have reanalyzed our data. This new analysis shows that serum sodium concentration decreased from 134.9 ± 6.6 mEq/L before the start of therapy to 130 ± 7.1 mEq/L after 2 days of treatment (P < 0.0001). Most importantly, 58% of patients developed a decrease in serum sodium concentration of more than 5 mEq/L (in these patients serum sodium concentration decreased from 136.4 ± 6.2 mEq/L to 127.7 ± 6.9 mEq/L; P < 0.0001), with 16% of patients developing a decrease of more than 10 mEq/L (Fig. 1). Therefore, our results suggest that even with duration of terlipressin treatment of only 2 days, serum sodium concentration should be monitored to allow an early detection of hyponatremia. We also would like to emphasize that hypotonic fluids should be avoided in patients with gastrointestinal bleeding treated with terlipressin to reduce the occurrence of hypovolemic hyponatremia, particularly in patients with low MELD scores that are at greatest risk to develop this complication. Individual values of serum sodium concentration in the nine patients who developed a decrease in serum sodium of greater than 10 mEq/L after 2 days of terlipressin treatment.
Accumulated Lead Exposure and Risk of Age-Related Cataract in Men—Correction
Authors: Steven Wartman, John Littlefield
Journal: JAMA (2005)

2004, and a reminder message was sent on April 5. Frequency distributions were computed for the 14 categorical response items.Results.Responses were obtained from 98 (78%) of the 126 schools surveyed.The responses to the first 12 questions are shown in the TABLE.Fifty-five percent of schools report that they have modified their curriculum as a result of the Step 2 CS.Fifty percent of schools require passing scores in clinical coursework before taking the Step 2 CS and 63% require a passing score on this examination prior to graduation.Seventy-two percent of schools are taking steps to assist students with fees for taking the Step 2 CS and 54% of the schools are providing a practice examination to assist students with preparation.Faculty support for the Step 2 CS is mixed (46% positive/very positive, 29% indifferent, and 22% negative).Comment.The addition of the Step 2 CS as a new licensure requirement has led to curricular and other modifications, including access to additional student financial aid in a majority of US medical schools.The governance of medical schools reflects the interplay of societal issues, scientific advances, faculty concerns, and regulatory requirements (eg, physician licensure and institutional accreditation).Achieving an appropriate balance among these components is a challenging task for individual schools.Making a change in one requirement appears to result in a broad investment of resources by medical schools.However, it is not clear how the educational value of this new intervention can be measured.We believe that there should be an overarching review of this complex web of interacting bodies that affects the education of our nation' s physicians.
The Seductress
Authors: Lynn Malinoff
Journal: Annals of Internal Medicine (2014)

Letters2 September 2014The SeductressLynn Malinoff, EdDLynn Malinoff, EdDFrom Eastern Michigan University, Ypsilanti, Michigan.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L14-5017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Johnson (1) passionately shares his experience working with a heroin addict. What his essay lacks is acknowledgment that addiction is a disease that, like cancer, is best left to professionals who know how to treat it. Far too often, physicians and other helpers impede recovery by their kindness and enabling behavior.The goal in treating patients with addiction is to form a therapeutic relationship to support them in a process of engaging in behaviors that they do not yet believe in, understand, or think will work in their particular case. Neither an authoritarian, angry approach nor an ...Reference1. Johnson RA. The seductress. Ann Intern Med. 2014;160:209. [PMID: 24658699] doi:10.7326/M13-0962 LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Eastern Michigan University, Ypsilanti, Michigan.Acknowledgment: Dr. Malinoff wrote this letter in collaboration with her husband, Herbert Malinoff, MD. He helped edit and revise the letter and contributed to the content.Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L14-0181. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe Seductress Russell Andrew Johnson The Seductress Russell Andrew Johnson The Seductress Russell Andrew Johnson Metrics 2 September 2014Volume 161, Issue 5Page: 376KeywordsAddictsBehaviorConflicts of interestDisclosureFearHeroin ePublished: 2 September 2014 Issue Published: 2 September 2014 Copyright & PermissionsCopyright © 2014 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...