tbuckley/cabot-search huggingface dataset:
Phase 1 pharmacokinetic and pharmacodynamic trial of docetaxel and 17AAG (17-allylamino-17-demethoxygeldanamycin)
Authors: D. B. Solit, M. Egorin, C. Kopil, A. Delacruz, D. Shaffer, S. Slovin, M. Morris, W. K. Kelly, N. Rosen, H. Scher
Journal: Journal of Clinical Oncology (2005)

3051 Background: 17AAG is an ansamycin antibiotic that binds to and inhibits the Hsp90 chaperone protein. Hsp90 is required for the refolding of proteins during cellular stress and the conformational maturation of a subset of signaling proteins. Treatment of cancer cells with 17AAG causes the proteasomal degradation of Hsp90 client proteins, which include HER2, steroid receptors, Raf, cdk4, and Akt. Hsp90 inhibition enhances the activity of taxanes in cell culture and animal models. Methods: We initiated a phase 1 study of docetaxel and 17AAG to define the maximally tolerated doses, toxicity profile, and pharmacodynamics of the combination. Patients (Pts) were treated with one of two schedules: docetaxel (55–75 mg/m2) followed by 17AAG (80–650 mg/m2) every 3 wks or docetaxel (35 mg/m2) and 17AAG (160 mg/m2) wkly x 3 every 28 days. Results: 40 pts (median age 64, range: 32–78) with cancers of the prostate (15), melanoma (7), H&N (5), renal (4), bladder (3), lung (3) and others (3 pts) have been treated with a median of 3 cycles (range: 1–11). An MTD has yet to be defined and dose escalation continues on both arms. Two dose limiting toxicities (both febrile neutropenia) have been observed. 17 pts have had Grade 4 neutropenia of less than 7 days duration. No CR/PR’s by RECIST criteria have been seen but minor responses have been observed in pts with prostate, lung, melanoma and urethral primaries. 12 pts had stable disease of at least 3 cycles duration and 7 pts stable disease for at least 6 cycles. Serum levels of docetaxel and 17AAG were not altered by co-administration at the dose levels studied. Peripheral blood lymphocytes (PBL) were collected to study changes in Hsp90-dependent client proteins as a function of dose. Post-treatment increases in Hsp70 in PBL have been observed in all pts treated with 17AAG at or above 110 mg/m2. Declines in Raf and Akt in PBL have been seen in some but not all pts treated at doses of 17AAG above 160 mg/m2. Conclusions: The combination of docetaxel and 17AAG is well tolerated at the dose levels studied to date. 17AAG dose escalation continues and at the time of the meeting updated accrual, response and correlative data will be reported. Supported by NIH P50-CA92629 and the Prostate Cancer Foundation. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Conforma Aventis, Conforma
Influence on outcome of time from myocardial infarction onset to primary angioplasty Thierry Lefevre, Christophe Loubeyre, Marie-Claude Morice, Yves Louvard, Fran�ois Gobeil, Rajpal Abhaichand, Jean-Fran�ois Pi�chaud. ICPS, Massy, France
Journal: Journal of the American College of Cardiology (2001)
Evaluation of the present status of DDT with respect to man
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Norway's decentralized, single-payer health system faces great challenges
Authors: M. Nylenna
Journal: JAMA (1995)

SOLIDARITY and equality form the ideological basis for the Scandinavian welfare state. In an international context the health care in Norway is characterized by a high level of education, proven medical competence, and equitable distribution of services. The main challenge for the future is an increasing gap between the capacity of the health services and the needs and expectations among patients. Waiting lists and rationing of health services represent significant threats to today's health care system in Norway. More resources and funding are needed to maintain the quality and public support and to avoid deterioration of the system. <h3>Norway—the Way to the North</h3> One of the northernmost countries in the world, Norway straddles the Arctic Circle, where the midnight sun shines during summer and the winters are dark and cold (Figure 1). Some 4.3 million inhabitants are scattered throughout an area of 324 000 km<sup>2</sup>, of which more than
Mental Subnormality
Authors: Hilda Knobloch, Benjamin Pasamanick
Journal: New England Journal of Medicine (1962)

IN the last decade there has been so much activity in the field of mental subnormality that any review will have to be selective and concentrate on areas that are important for demonstrating etiology so that preventive measures can be applied, for improving function by specific therapy in persons already affected and for indicating directions for further research or for programs of action in treatment or management.A joint expert committee of the World Health Organization1 defines mental subnormality as incomplete or insufficient general development of the mental capacities. It separates subnormality into its two major components, retardation and deficiency. . . .
ENDOCRINOLOGY
Authors: LEWELLYS F. BARKER
Journal: JAMA (1922)

This symposium on internal secretions includes several papers that deal chiefly with the physiologic, the pathologic and the therapeutic effects of endocrine substances. I have been asked to make, by way of introduction, some general remarks on the subject of endocrinology as a whole. A discussion of the topic is timely and should be of value to workers in every branch of medicine. The profession in general is evincing a lively interest in the internal secretions, as is shown by the titles of papers read at medical meetings. An association for the study of the internal secretions already has a large membership, and its special journal,<i>Endocrinology</i>, is widely read. <h3>THE ENDOCRINE ORGANS</h3> Organs of the body that yield to the blood, in addition to the common metabolites resulting from the general life processes of cells, certain specific products that influence distant parts have been designated "endocrine organs," and the
Ultra-Violet Therapy in Eye Disease with a Review of the Action of Other Forms of Radiant Energy
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 3121: Osteopontin-c is overexpressed and mediates cell adhesion and proliferation in leukemia cell line with <i>KMT2A-AFF1</i>
Authors: Ana Clara Santos da Fonseca Bastos, Júlio César Santoro, Caroline Barbieri Blunck, Luciana Bueno Ferreira, Maria do Soccro Pombo-de-Oliveira, Mariana Emerenciano, Etel R. Gimba
Journal: Cancer Research (2019)

Abstract Osteopontin (OPN) primary transcript suffers alternative splicing generating at least five OPN splicing isoforms (OPN-SI) named OPNa, OPNb, OPNc, OPN4 and OPN5. In solid tumors, total OPN (tOPN) expression has been correlated to several cancer features. However, OPN-SI roles in hematological malignancies are still under investigation. A hallmark of B-cell acute lymphoblastic leukemia (B-ALL) is the recurrence of specific gene rearrangements associated with prognostic risk stratification. Patients harbouring the KMT2A-AFF1 fusion gene are included into poor prognostic subgroup, with an overall survival rate of 50% and increased risk of extramedullary sites involvement. In B-ALL, it has been reported that tOPN support tumor dormancy and cell survival in response to chemotherapeutic drugs. However, the specific roles of OPN-SI have not been addressed. The aim of this study was to analyze the expression of OPN-SI in B-ALL samples and then investigate the role of the most overexpressed OPN-SI on modulating cellular and molecular aspects of B-ALL presenting KMT2A-AFF1. We found that OPNc is overexpressed in relation to OPNa and OPNb in patients with KMT2A-AFF1. In addition, OPNc transcript levels were associated with poor prognostic features, such as central nervous system infiltration, white blood cell counting and the high-risk group at diagnosis. In response to OPNc silencing in B-ALL cell lines, we found increased proliferation rates, as opposed to decreased cell adhesion properties over matrigel matrix. Our data evidenced that overexpressed OPNc in B-ALL with KMT2A-AFF1 is correlated to poor prognostic features and may modulate the leukemic phenotype by the decrease of cell proliferation while promoting cell adhesion. Further work should be conducted in order to evaluate OPNc putative application as an additional risk-stratification and prognostic marker for B-ALL and how OPNc could control leukemia development and progression. Note: This abstract was not presented at the meeting. Citation Format: Ana Clara Santos da Fonseca Bastos, Júlio César Santoro, Caroline Barbieri Blunck, Luciana Bueno Ferreira, Maria do Soccro Pombo-de-Oliveira, Mariana Emerenciano, Etel R. Gimba. Osteopontin-c is overexpressed and mediates cell adhesion and proliferation in leukemia cell line with KMT2A-AFF1 [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3121.
Psychophysiological Evidence of Altered Neural Synchronization in Cannabis Use: Relationship to Schizotypy
Authors: Patrick Skosnik
Journal: American Journal of Psychiatry (2006)

Objective: Cannabis use may produce neurophysiological disturbances similar to those observed in schizophrenia, particularly in relation to altered neural synchronization. Therefore, the current experiment examined the effect of cannabis use on EEG neural synchronization using the auditory steady-state evoked potential. Method: Auditory steady-state evoked potentials were assessed using varying rates of stimulation (auditory click-trains of 20, 30, 40 Hz) in current cannabis users (N=17) and drug-naive comparison subjects (N=16). EEG spectral power and signal-to-noise ratio at each stimulation frequency were compared between groups. Results: Cannabis users showed decreased EEG power and signal-to-noise ratio at the stimulation frequency of 20 Hz. In addition, current cannabis users demonstrated increased schizotypal personality characteristics as assessed with the Schizotypal Personality Questionnaire, which positively correlated with total years of cannabis use. Finally, within the cannabis group, 20-Hz power values were negatively correlated with Schizotypal Personality Questionnaire scores. Conclusions: These data provide evidence for neural synchronization and early-stage sensory processing deficits in cannabis use. This finding, along with the observed increased rates of schizotypy in cannabis users, adds support for a cannabinoid link to schizophrenia spectrum disorders.
Cosmetic Surgery
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Advances in hemoglobin disorders
Authors: Maria Domenica Cappellini
Journal: HemaSphere (2018)

University of Milan, Foundation IRCCS Policlinico Hospital, Milan, Italy This is an open access Abstract Book distributed under the Attribution-NonCommercial-NoDerivs (CCBY-NC-ND), which allows third parties to download the abstracts and share them with others as long as they credit the author and the abstract book, but they cannot change the content in any way or use them commercially. http://creativecommons.org/licenses/by-nc-nd/4.0
Infantile Pyknocytosis
Authors: Rudolph Keimowitz, Jane F. Desforges
Journal: New England Journal of Medicine (1965)

THE syndrome of infantile pyknocytosis was first described by Tuffy et al.1 in 1959. Since that time very little has been written about this disorder although several reports have described erythrocyte distortion in various diseases. Recently, we observed a child with infantile pyknocytosis and performed studies that may cast light on the nature of the defect in this syndrome.Case ReportThis male infant was born at Boston City Hospital (2031441) to a 22-year-old white gravida 4, para 4, at approximately 32 weeks' gestation. The mother had no prenatal care, but apparently had had an uneventful pregnancy and had taken . . .
The effect of hospital financial characteristics on quality of care
Authors: H. R. Burstin
Journal: JAMA (1993)

<h3>Objective.</h3> —To assess the relationship among hospital financial characteristics, patient payer mix, and the incidence of negligent medical injuries. <h3>Design.</h3> —Retrospective medical record review linked to hospital financial reports. <h3>Setting.</h3> —Acute care hospitals in New York State in 1984. <h3>Population.</h3> —Stratified, random sample of 30195 medical records from 51 acute care hospitals. <h3>Main Outcome Measures.</h3> —Hospital rates of medical injury and substandard care were developed from reviews of 30195 medical records at 51 acute care hospitals in New York in 1984. Hospital-level variables representing financial status, hospital staffing, and the proportion of self-pay and Medicaid hospital discharges were compiled from a variety of secondary sources. <h3>Results.</h3> —The likelihood of negligent medical injury was highest in those hospitals with the lowest inpatient operating costs per hospital discharge (odds ratio, 2.8; 95% confidence interval, 1.5 to 5.5). The effect of low inpatient operating costs was marked among hospitals in financial distress, many of which served indigent populations. <h3>Conclusions.</h3> —Patients admitted to hospitals that are unable to expend sufficient resources on patient care may be at higher risk of substandard care. Further study of the effect of hospital financial status on quality of care appears to be warranted. (<i>JAMA</i>. 1993;270:845-849)
HIV Misdiagnoses
Authors: Rebecca Voelker
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 4168: Identify the predisposition genes to endometrial cancer
Authors: Yu-Cheh Chiang, Ting-Fang Lee, Yung-Feng Lin, Hui-Ying Weng, Shih-Feng Tsai, Cheng-Wen Wu
Journal: Cancer Research (2019)

Abstract Endometrial carcinoma is the most dominant gynecological tumor worldwide. Familial risk of endometrial cancer has been reported but little is known about the predisposition genes. Here we focused on a family with high incidence of cancer, aiming to identify potential markers with low allele frequency and high disease-causing probability. Whole-genome sequencing was performed with available DNA from 4 family members: one healthy control and 3 endometrial cancer patients. We analyzed the non-synonymous variations in the coding region expressed in 3 of the patients but not in the healthy control. The variations with high allele frequencies in Taiwanese population were excluded. Five potential candidates, KMT2D, PCDHA8, COG5, RAPGEF3 and PFDN1, were identified as heterozygous mutations predisposed to endometrial cancer. In addition, we demonstrated that PCDHA8 and COG5 genes play crucial roles in cell proliferation in endometrial cancer cells. Notably, KMT2D (lysine methyltransferase 2D) is highly mutated in the tumors of endometrial cancer. An interaction between mutated KMT2D and other candidate genes may explain the high risk of cancer formation in this family. These results validate the potential markers of endometrial cancer and create opportunities for therapeutic applications and personalized prevention. Citation Format: Yu-Cheh Chiang, Ting-Fang Lee, Yung-Feng Lin, Hui-Ying Weng, Shih-Feng Tsai, Cheng-Wen Wu. Identify the predisposition genes to endometrial cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4168.
Remarks on the Present Aspect of Medicine
Authors: W. Newnham
Journal: BMJ (1848)

To those who have watched the progress of medicine foi-the last few years, and who have noticed the first dawn and gradual development of that revulsion from heroic treatment, to a modified system of expectant medicine, it is impossible not to perceive that the great apostle of tbe Natural History of Disease is the talented author of' the pampblet entitled " Homeeopathy, Allopathy, and Young Physic"; and in a review of the present state of medicine, it would be impossible to avoid tracing the germs of the present transition stage, and noticing in detail the structure of this brochure.In the perusal of this pamphlet, two things especially fastened upon the memory-first, the course of argi-
Domestic Abstracts
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Error in Abstract and Results
Journal: JAMA Network Open (2020)

In the Original Investigation titled "Comparison of Office-Based Physician Participation in Medicaid Managed Care and Health Insurance Exchange Plans in the Same US Geographic Markets," 1 published April 13, 2020, there was an error in the reporting of statistical measures of physician network coverage that appeared in the Abstract and Results sections.These values should have appeared as means with standard deviations instead of medians with interquartile ranges and means with 95% confidence intervals.This article has been corrected.
Dosage of potassium chloride elixir to correct thiazide-induced hypokalemia
Authors: A. B. Schwartz
Journal: JAMA (1974)

The oral dose of 10% potassium chloride elixir required to reverse thiazide-induced hypokalemia was determined in 15 patients with essential hypertension. Each patient had maintained a serum K concentration of at least 0.5 mEq/liter less than duplicate control values (mean decreases, 0.62 mEq/liter) for at least two months during therapy with hydrochlorothiazide, 50 mg twice daily. Potassium chloride 10% elixir was administered in a total daily dose of 40 mEq, with bimonthly increments to 60 mEq, 80 mEq, and 100 mEq, while the thiazide administration was maintained. The serum K deficit was repleted to 75% in 12 of the 15 patients. In eight of the 12, this was accomplished with 40 mEq potassium chloride daily, and in four, with 60 mEq daily. The latter dose is recommended in patients with thiazide-induced hypokalemia. (<i>JAMA</i>230:702-704, 1974)