tbuckley/cabot-search huggingface dataset:
Intoxication, Addiction Possible With Non-Barbiturate Drugs
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fibrosing Skin Condition Among Patients With Renal Disease—United States and Europe, 1997-2002
Journal: JAMA (2002)

During May 1997-November 2000, eight (3%) of 265 kidney transplant recipients at a hospital in California developed an unusual skin condition posttransplant (Figure 1). On clinical examination, the patients had fibrotic skin lesions histologically resembling scleromyxedema on their distal extremities and trunk, resulting in severe contractions and limited mobility. However, the usual IgG lambda paraprotein associated with scleromyxedema was not observed in these patients. Personnel in the dermatopathology section at the University of California, San Francisco, reviewed the biopsies and concluded that this skin disorder had not been described previously. As a result, health-care providers at the hospital where the index patient was treated asked the California Department of Health Services (CDHS) and CDC to assist in the investigation. This report summarizes preliminary findings from the investigation.
Interaction of human gallbladder mucin with calcium hydroxyapatite: Binding studies and the effect on hydroxyapatite formation
Authors: Sui-Min Qiu, Gary Wen, Julie Wen, Roger D. Soloway, Roger S. Crowther
Journal: Hepatology (1995)

Calcium hydroxyapatite (HAP) crystals formed in vitro in the presence of polymeric human gallbladder mucin (1.0 mg/mL) were smaller (0.75 ± 0.39 μm) than control crystals (7.86 ± 2.76 μm), but the mucin did not affect the kinetics of crystal formation or alter the amount of mineral phase present at equilibrium. In contrast, glycopeptide subunits produced by proteolysis of the native mucin had no effect on HAP crystal size. Both native mucin and glycopeptides bound to mature HAP crystals, but the glycopeptides were much more readily displaced by phosphate ions. Therefore, in experiments where HAP was being formed, the phosphate ions inhibited the interaction of glycopeptides with the nascent HAP. These results indicate that gallbladder mucin may modulate HAP formation in vivo , and that this ability may be altered during pathological states, such as neutrophil infiltration or bacterial colonization, that may cause the release of proteinases capable of digesting mucin.
Normal-pressure hydrocephalus. Role of cisternography in diagnosis
Authors: A. E. James
Journal: JAMA (1970)

Normal-pressure hydrocephalus is characterized by neurological symptoms of dementia and awkwardness of movement, cerebrospinal fluid pressure in the normal range, and ventricular enlargement without cortical atrophy. Pneumoencephalograms reveal enlarged ventricles with failure of air to pass over the cerebral convexities. The cisternographic abnormalities are the presence of radioactivity in the enlarged ventricles, abnormality of movement of the injected radioactivity over the cerebral hemispheres, and failure of the radioactivity to concentrate in the sagittal area on delayed scans (24 or 48 hours). Since normal-pressure hydrocephalus is a treatable form of dementia, accurate diagnosis based on clinical manifestations, findings from lumbar puncture, pneumoencephalography, and cisternography is mandatory.
VICTOR Spoiled?
Authors: Richard M. Goldberg, Monica M. Bertagnolli
Journal: Journal of Clinical Oncology (2010)

this kind may well limit the ability of patients to tolerate this regimen, because they may collectively reduce quality of life and may affect patient willingness to continue treatment.Despite this, the combination was considered tolerable and was associated with inhibition of several pharmacodynamic end points at the identified maximumtolerated dose (including inhibition of 4E binding protein 1 phosphorylation, a surrogate of mTOR pathway activity).A PK drug-drug interaction was also partly assessed in this trial.Although clinically relevant PK interactions were not noted, there appeared to be acceptable interpatient variability of capecitabine levels, whereas a greater degree of variability was observed for ridaforolimus.Importantly, ridaforolimus (just like rapamycin) inhibited dihydropyrimidine dehydrogenase, suggesting a class effect for mTOR inhibitors on the enzyme.It is interesting to note that at its nadir, dihydropyrimidine dehydrogenase activity was always above the threshold level associated with risk of severe fluoropyrimidineassociated toxicity, which is reassuring, given that the toxicity profile of this combination is further refined in future studies.Although Perotti et al 2 suggest that this combination is clinically active, it is impossible to know whether this was related to either of the single agents alone, or whether a prolonged period of stable disease was related to the tumor's natural history in the absence of therapy.In this respect, phase I combination studies, 5 as well as nonrandomized phase II studies, 4,7 are limited in their ability to accurately assess clinical activity.This is partly because such studies are commonly performed in populations of patients that are either extensively pretreated or highly selected because of toxicity-related concerns. 8 In addition, homogeneous groups of patients are typically not treated at the maximum-tolerated dose of the regimen.Although we list clinical activity as a criterion in Table 1, it is considered a minor element because response data in phase I trials are unreliable surrogates for the ultimate value of the combination.Thus, clinical activity in a phase I trial will not be considered a sufficient reason for acceptance in the absence of the major criteria listed in Table 1.It is likely that the success of targeted therapies will depend on their rational use in combination with other agents that affect intersecting pathways of tumor growth, survival, angiogenesis, and drug resistance.As such, the editors recognize the importance of performing combination phase I studies using targeted agents, but at the same time realize that not all combination studies will be informative.The criteria outlined in Table 1 should serve as a guide to readers as they assess the relative merits of combination phase I trials, and will be helpful to prospective authors considering such articles for publication in JCO.
Clinical Lectures on Dislocations, Delivered at the Charing - Cross Hospital. Summer Session, 1844
Authors: H. Hancock
Journal: BMJ (1844)

I shall commence the present lecture by describ- ing to you the appearances which the shoulder presents in its natural state, and also the points or processes necessary to be observed in relation to dislocations of the joint.The sboulder is somewhit-conical in shape, the base being at the axillary boide, whilst the apex is directed upwards and forwards.It presents four aspects-an anterior, posterior, superior, and external.On the anterior aspect, commencing at the border of the axilla, is a deep groove leading up to the anterior margin of the clavicle, at about an inch and a half from its acromial extremity, at the angle between its concave and convex portions.Place your finger upon this-spot, and carry it outwards and then backwards around the shoulder, and you will be able to trace the end of the clavicle, the acromion process, and, lasey, the spine of the scapula, very well marked, and easily discemed, especially in thin muscular individuals.Next retrace your finger and place it in the groove immediately below the clavicle.This spot corresponds to the division between the anterior edge of the deltoid and upper edge of the pectoralis major muscles.Carry your finger out- wards and you will then feel the dense ligament or rather fascia extending from the coracoid process to the clavicle and ribs, the coracoid process, the anterior edge of the deltoid muscle, and the pro- minence of the bead of the humerus.On the pos- terior aspect you may observe the supra-spinal fossa, beneath which is the spine of the scapula; pass your finger along this process from within, out.wards, or from the vertebrm towards the humerus, and you will be able to feel the well defined pos- terior margin of the acromial process, beneath wbieh, if you exercise a little pressure upon the posterior portion of the deltoid muscle, you will
THE TREATMENT OF GENERAL PARALYSIS BY FEVER-PRODUCING METHODS
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A study of IgE and RAST levels in patients with chronic atopic dermatitis
Authors: Rona M. MacKie, Rebecca Cochran, J. Thomson, Sue Cobb
Journal: British Journal of Dermatology (1978)

Journal Article A study of IgE and RAST levels in patients with chronic atopic dermatitis Get access Rona M. MacKie, Rona M. MacKie Departments of Dermatology and Immunology, Western Infirmary and Departments of Dermatology, Stobhill, Hospital and Glasgow Royal Infirmary Search for other works by this author on: Oxford Academic Google Scholar Rebecca Cochran, Rebecca Cochran Departments of Dermatology and Immunology, Western Infirmary and Departments of Dermatology, Stobhill, Hospital and Glasgow Royal Infirmary Search for other works by this author on: Oxford Academic Google Scholar J. Thomson, J. Thomson Departments of Dermatology and Immunology, Western Infirmary and Departments of Dermatology, Stobhill, Hospital and Glasgow Royal Infirmary Search for other works by this author on: Oxford Academic Google Scholar Sue Cobb Sue Cobb Departments of Dermatology and Immunology, Western Infirmary and Departments of Dermatology, Stobhill, Hospital and Glasgow Royal Infirmary Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 99, Issue s16, 1 December 1978, Page 15, https://doi.org/10.1111/j.1365-2133.1978.tb15208.x Published: 01 December 1978
Inconvenient truths
Authors: M. Aitken
Journal: Journal of the Royal Society of Medicine (2007)

By couching the discussion of Blair and Bush in terms of hubris and nemesis, Lord Owen 1 has avoided the pitfall of diagnosis from afar while still highlighting serious problems with the two world leaders (JRSM November 2006).He does dip his toe into psychodynamics citing Freud and Justin Frank, but, by and large, he sticks to discussing behaviour and its relation to hubris and power.As a politician, Lord Owen is qualified to discuss the political leaders he has encountered.As a physician, should he be making medical judgments on political leaders?Simon Wessely has questions about this and about whether or not psychiatrists should venture beyond the consulting room. 2 Should psychiatrists limit their judgments to patients they have examined?The American Psychiatric Association says 'yes' and Dr Wessely cites data to support that view.But the question remains, can psychiatrists and neuroscientists, with the help of philosophers, provide useful insights that contribute to the understanding of leaders and their followers?I believe that we should try.We should bring whatever scientific data there may be to counter ideology, blind faith and the intoxicating effects of power.It is true hubris often comes with power.Even though we do not have a psychiatric diagnosis for hubris, it is a psychological entity and as such should potentially be understood by science, as are other psychological phenomena.We do not diagnose those that we have not personally examined and we cannot diagnose an entire population, but perhaps we can bring clinical and scientific insights to help understand destructive behaviour As scientists and clinicians, we too must guard against hubris.Hopefully our colleagues will help us with that.JRMS should be applauded for exploring the issue.
The care of patients with AIDS: don't ignore the family practitioner
Authors: Louise Clark, Jill Ginsberg
Journal: JAMA (1989)

<h3>To the Editor.—</h3> We find it disturbing that authors who write about "primary care" of patients with acquired immunodeficiency syndrome (AIDS) neglect family physicians in their discussion of who is or who should be caring for human immunodeficiency virus (HIV)—infected patients. In her recent article, Dr Cotton<sup>1</sup>listed general internists, pediatricians, oncologists, and infectious disease specialists as the physicians who will need to provide the manpower in meeting the challenge of AIDS yet neglected to mention family physicians. Family physicians care for patients in all age groups and are at the forefront of HIV risk-reduction education for patients at all life stages. Testing and counseling are becoming routine in many family practice settings.<sup>2</sup>Family physicians must, at a minimum, know how HIV infection presents in children, in pregnant women, and in adults. In addition, many family physicians continue to care for patients with AIDS and their families throughout
Experimental Colon Cancer Test Appears to Hold Promise
Authors: J. Stephenson
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reply†
Authors: Elisa Fabbrini, Shelby Sullivan, Samuel Klein
Journal: Hepatology (2010)

We appreciate the interest and comments of Dr. Purnak and colleagues1 regarding our review of obesity and nonalcoholic fatty liver disease (NAFLD).2 Their letter highlights a potential role of inadequate brown adipose tissue (BAT) activity in the pathogenesis of excessive intrahepatic triglyceride (IHTG) accumulation. The recent identification of BAT depots in adult humans, obtained by using positron emission tomography scanning techniques,3 and the observation that the amount of BAT is inversely correlated with body mass index,4 have led to an increased interest in the potential importance of BAT in regulating body weight and as a potential target for treating obesity. Uncoupling oxidative phosphorylation from adenosine triphosphate production in BAT increases energy expenditure, which is dissipated as heat. Therefore, inducing BAT thermogenesis could alter whole-body energy balance, resulting in the mobilization and use of endogenous triglycerides as fuel to meet the increase in energy demand. This negative energy balance would decrease both body fat mass and IHTG content. We agree that more research is needed to determine the relationship between BAT and NAFLD, and whether differences in BAT activity are involved in the development of steatosis. Elisa Fabbrini* , Shelby Sullivan*, Samuel Klein*, * Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, St. Louis, MO, Center for Clinical and Basic Research, Department of Medical Sciences, IRCCS (Istituto Di Ricovero è Cura a Carattere Scientifico) San Raffaele, Rome, Italy.
Corrigenda
Journal: BMJ (1935)

Obsolescence Allowance of Car G. P. N." replaced his car in 1929-30 and then claimed to deduct the cost of ieplacement, and in consequence was debarred from claiming " depreciation " allowance on the car then purchased for £302 for 1930-1.In February, 1935, he sold that car for £38 and bought a second-hand car for £195.What can he now claim (a) in respect of obsoles- cence, and (b) for depreciation of the new car?*** (a) The obsolescence allowance due as an expense of the year to March 31st, 1935, is £143 as calculated by "G.P. N." -that is, on the basis of deducting from the £302 cost the appropriate depreciations at 20 per cent., excluding the " barred " allowance for 1930-1.As regards private use-now 1/5, formerly 1/3-this should strictly be averaged out over the full period, but the authorities may not take that point against " G. P. N.," and in any case the difference would not be substantial.
Grieving
Authors: Carey E. Gross
Journal: JAMA (1984)

On a December night, Gary was shot and killed on the street. It happened during our junior year of college. For nearly 16 years we had been companions and confidantes, passing through childhood, adolescence, and early adulthood together. Each of us had always provided the other a word of encouragement, an available ear, a shoulder to lean on. In school, sports, and play we competed as equals, and as our lives unfolded, our friendship developed with the same equality. Staring at his body in the funeral home left me bewildered: Where had Gary gone? This had happened just as he and I thought we had begun to untangle some of life's intricacies. I was 20 years old, and the confrontation with mortality left me breathless, robbed of my desire to fight. I went through the motions of being back in school. Each day I attended classes and meals. But every
Transplacental Hemorrhage
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
“ERS and tobacco harm reduction.” Charlotta Pisinger, Elif Dagli, Filippos T. Filippidis, Linnea Hedman, Christer Janson, Stelios Loukides, Sofia Ravara, Isabel Saraiva and Jørgen Vestbo, the ERS Tobacco Control Committee, on behalf of the ERS.<i>Eur Respir J</i>2019; 54: 1902009.
Journal: European Respiratory Journal (2020)
Correction: Paclitaxel Sensitivity of Ovarian Cancer Can be Enhanced by Knocking Down Pairs of Kinases that Regulate MAP4 Phosphorylation and Microtubule Stability
Authors: Hailing Yang, Weiqun Mao, Cristian Rodriguez-Aguayo, Lingegowda S. Mangala, Geoffrey Bartholomeusz, Lakesla R. Iles, Nicholas B. Jennings, Ahmed Ashour Ahmed, Anil K. Sood, Gabriel Lopez-Berestein, Zhen Lu, Robert C. Bast
Journal: Clinical Cancer Research (2020)
The Molecular Basis of Chemical Toxicity
Authors: James D. McKinney
Journal: Environmental Health Perspectives (1985)

Studies of structure-activity relationships and molecular mechanisms of action are fundamental to our understanding of the harmful effects of chemicals on the environment and their more direct effects on human health. It is important to identify factors that determine toxicological effects of foreign chemicals in biological systems and to assess our knowledge about chemical mechanisms of toxicity. Several fundamental mechanisms underlying toxic action are described, and the importance of studying receptor-substrate interactions is stressed. The Ah receptor is cited as an example of a protein-small molecule interaction associated with extreme acute toxicity in laboratory animals. It is recognized that reliable attempts at predictive toxicology across compound classes through structural and theoretical chemistry approaches must be based on sound knowledge about mechanisms of action at the molecular level. Such studies also contribute to the knowledge base in biomedical and physical sciences.