Gastrin
Authors: MORTON I. GROSSMAN
Journal: Annals of Internal Medicine (1966)

Editorials1 January 1966GastrinMORTON I. GROSSMAN, M.D.MORTON I. GROSSMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-1-212 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDuring all but the last few of the 60 years that have passed since gastrin was discovered, the major question that concerned authors of papers on this subject was whether the hormone did in fact exist. This question was recently answered definitively when Gregory and his coworkers (1), Anderson and coworkers (2), and Tracy and Gregory (3) isolated gastrin in pure form from the mucosa of the pyloric gland area of the stomach, determined its full chemical structure, and proved the correctness of this structure by total synthesis.Like the other gastrointestinal hormones, gastrin is a polypeptide. Gastrin derived from...References1. GREGORYHARDYJONESKENNERSHEPPARD RAPMDSGWRC: The antral hormone gastrin. Nature 204: 931, 1964. CrossrefMedlineGoogle Scholar2. ANDERSONBARTONGREGORYHARDYKENNERMACLEODPRESTONSHEPPARDMORLEY JCMARAPMGWJKJRCJS: Synthesis of gastrin. Ibid., p. 933. Google Scholar3. TRACYGREGORY HJRA: Physiological properties of a series of synthetic peptides structurally related to gastrin I. Ibid., p. 935. Google Scholar4. TAUBERMADISON SLL: The isolation and characterization of porcine gastrin. J. Biol. Chem. 240: 645, 1965. CrossrefMedlineGoogle Scholar5. MAKHLOUFMCMANUSCARD GMJPWI: Dose-response curves for the effect of gastrin II on acid gastric secretion in man. Gut 5: 379, 1964. CrossrefMedlineGoogle Scholar6. MAKHLOUFMCMANUSCARD GMJPWI: The action of gastrin II on gastric-acid secretion in man. Comparison of the maximal secretory response to gastrin II and histamine. Lancet 2: 485, 1964. CrossrefMedlineGoogle Scholar7. GROSSMAN MI: Integration of neural and hormonal control of gastrin secretion. Physiologist 6: 349, 1963. Google Scholar8. PRESHAWCOOKEGROSSMAN RMARMI: Pancreatic secretion induced by stimulation of the pyloric gland area of the stomach. Science 148: 1347, 1965. CrossrefMedlineGoogle Scholar9. GREGORYTRACY RAHJ: The constitution and properties of two gastrins extracted from hog antral mucosa. Gut 5: 103, 1964. CrossrefMedlineGoogle Scholar10. DELEUTYTGATVAN GOIDSENHOVEN JHGE: Diarrhea associated with pancreatic islet-cell tumors. Amer. J. Dig. Dis. 9: 97, 1964. CrossrefMedlineGoogle Scholar11. SCOBIEMCGILLPRIESTLEYROVELSTAD BADBJTRA: Excluded gastric antrum simulating the Zollinger-Ellison syndrome. Gastroenterenterology 47: 184, 1964. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: MORTON I. GROSSMAN, M.D.Affiliations: Veterans Administration Center Los Angeles, Calif. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMorton I. Grossman, M.D. Ph.D.: An Oral HistoryShock predictability and plasma gastrin in the ratThe inhibition of gastrin induced duodenal ulcer by fat or acid in small intestineSOLID PHASE SYNTHESIS OF PENTAGASTRIN AND OTHER PEPTIDE AMIDES BY A MODIFIED TECHNIQUEPhysiology of gastrinHumoral Effects of the Pancreas Upon the Gastrointestinal TractSome Aspects of Gastric SecretionPeptic Ulcerations in ChildhoodGastrin—Reminiscence and speculation 1 January 1966Volume 64, Issue 1Page: 212-216KeywordsGastric mucosaGastrinHormonesMucous membranesPeptide hormonesPolypeptidesStomach ePublished: 1 December 2008 Issue Published: 1 January 1966 PDF downloadLoading ...