tbuckley/cabot-search huggingface dataset:
Risk-taking behaviors in adolescence
Authors: D. E. Greydanus
Journal: JAMA (1987)

The biopsychosocial phenomenon of adolescent substance use is of major importance to all health care professionals. As suggested by the excellent study of Robinson et al<sup>1</sup>in this issue ofThe Journaladolescent substance use should be viewed within the larger perspective of adolescent risktaking behaviors.<sup>2</sup>Much of adolescent behavior consists of experimenting with a variety of activities, many potentially perilous, including sex, substance use, and violence. But to understand and find solutions to the risk-taking behavior of youth, we have to understand adolescence in today's culture. To be an adolescent today is difficult. Pregnancy, incest, sexual abuse, rape, suicide, homicide, prostitution, and other devastating problems are all integral facts of life. Sexual experimentation, for example, often has tragic results as adolescents tend to show little insight into the consequences of their actions. Millions of cases of sexually transmitted diseases and pregnancies are reported annually in teenagers. Adolescent
POSTGRADUATE INSTRUCTION IN VIENNA
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Effect of Falsified<i>Clostridium difficile</i>Infections Surveillance Data on Results Reported in<i>MMWR</i>
Journal: MMWR Morbidity and Mortality Weekly Report (2015)

In 2012, MMWR published the report, "Vital Signs: Preventing Clostridium difficile Infections," which examined Clostridium difficile infection (CDI) surveillance data. This report contained several errors pertaining to Emerging Infections Program (EIP) data. These errors occurred as a result of scientific misconduct by a former employee of the Oregon Health Authority. The Public Health Service Office of Research Integrity has determined that the former employee falsified or fabricated data for 56 Oregon EIP CDI case report forms (https://ori.hhs.gov/content/case-summary-asherin-ryan). The authors re-analyzed the EIP data to determine if the removal of all Oregon CDI cases (57 total cases) from the 10,342 cases included in the original publication altered the previously reported results. It did not. Re-analysis confirms the conclusions in the original report. Data in the original report from sources other than the Oregon Health Authority (i.e., from other EIP sites, the National Healthcare Safety Network, and Illinois, Massachusetts, and New York CDI prevention programs) were not involved in the research misconduct.Errata for the 2012 report have been published in this issue of MMWR.
Contents page + Editorial Board
Authors: Louise Donnelly, Peter Barnes, Nieves Ferna ´ndez, Sonia Jancar, Mariano Sa ´nchez Crespo, Shinji Takai, Denan Jin, Michiko Muramatsu, Mizuo Miyazaki, Scott Henry, Eric Marcusson, Thomas Vincent, Nicholas Dean, Alastair Poole, Giordano Pula, Ingeborg Hers, David Crosby, Matthew Jones, Olivier Feron, Frederik Igney, Khusru Asadullah, Thomas Zollner Trendsin
Journal: Trends in Pharmacological Sciences (2004)
皮肌炎的细胞因子和趋化因子
Authors: M. Chen, C. Quan, L. Diao, F. Xue, K. Xue, B. Wang, X. Li, X. Zhu, J. Zheng, H. Cao
Journal: British Journal of Dermatology (2018)

皮肌炎 (DM) 是一种慢性免疫疾病,主要影响肌肉、皮肤,甚至肺部和心脏。目前正在研究 DM 的确切病因和运作方式,以及用于监测患者疾病活动和预测其对治疗的反应的方法。细胞因子和趋化因子的异常在炎症性疾病中很常见,它们可能在 DM 中起作用。本研究旨在发现患有 DM 或一种被称为临床淀粉样肌炎 (CADM) 的亚型疾病的人群的血液中细胞因子和趋化因子水平与症状严重程度之间的关系,特别是皮肤病变(受影响的斑块)和间质性肺病(ILD – 用于描述一系列肺部疾病的一个术语)。他们邀约了 40 名 DM/CADM 患者,采集血液样本,评估皮肤病变的规模,并在患者第一次医院就诊时获取其他信息。研究人员发现,拥有更高水平的细胞因子 IFN‐β 和趋化因子 CXCL‐10 的血液与更严重的症状(更高的疾病活动)有关联。患有一种被称为急性/亚急性间质性肺炎 (A/SIP) 的 DM/CADM 患者的血液中细胞因子 IL‐6、IL‐10、IL‐18、IFN‐β 水平要明显高于未患该疾病的人。血液中 IL‐6 和 IL‐18 水平越高,一种名为抗 MDA5 的抗体水平就越高(抗体由免疫系统产生以抵抗疾病和感染)。总之,在评估 DM/CADM 中的皮肤疾病活动时,血液中的 IFN‐β 和 CXCL‐10 水平可能是有用的。细胞因子 IL‐6、IL‐10、IL‐18 和 IFN‐β 与 A/SIP 的发生高度相关。此外,IL‐6 和 IL‐18 可能在抗 MDA5 抗体相关的 ILD 的形成过程中发挥作用。这些结果可能有助于更好地理解 DM/CADM。
Pulse
Journal: JAMA (1993)

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JAMA Reference Directories
Journal: JAMA (1984)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reply
Authors: Elliot B. Tapper, David Ratz, Anna S.‐F. Lok, Grace L. Su
Journal: Hepatology (2018)

Potential conflict of interest: Nothing to report. We thank Drs. Ridola and Riggio for their interest in our study on the risk of hepatic encephalopathy (HE) in a population‐based cohort of American veterans.1 In their letter, Drs. Ridola and Riggio raised several interesting points. First, they requested that we apply competing‐risk analysis to our data set. We have redone the analyses using competing‐risk regression based on Fine and Gray's proportional subhazards model (Table 1). The statistical significance of final model selections is no different, and effect estimates are largely unchanged. Table 1 - Similar Results Obtained With Original Cox Regression and Competing‐Risk Analysis Modela Parameter Original Cox Regression Competing‐Risk Regression Baseline model Albumin 0.54 (0.49‐0.60) 0.71 (0.64‐0.78) Bilirubin 1.07 (1.05‐1.09) 1.05 (1.03‐1.08) Beta‐blocker 1.27 (1.04‐1.55) 1.26 (1.02‐1.55) Statin 0.75 (0.61‐0.90) 0.72 (0.58‐0.87) Longitudinal model Albumin 0.42 (0.38‐0.46) 0.59 (0.54‐0.66) Bilirubin 1.11 (1.09‐1.13) 1.07 (1.04‐1.11) Beta‐blocker 1.51 (1.28‐1.77) 1.68 (1.39‐2.02) Statin 0.79 (0.65‐0.96) 0.75 (0.61‐0.91) aBaseline models only include variables as assessed at study enrollment, whereas longitudinal models update inputs as the values change. In the new competing‐risk regression, the significance of the final parameters is unchanged and effect size estimates, if different, have not changed in clinically meaningful ways. We also agree with Ridola and Riggio that the presence of minimal HE is predictive of incident overt HE.2 However, minimal HE is not routinely evaluated in clinical practice. Further, studies of minimal HE diagnostics, such as the animal naming test,3 uniformly excluded patients with psychiatric disorders, alcohol misuse in the previous 6 months, any psychoactive medication, and heart, respiratory, or renal failure. These comorbidities characterize roughly half of our cohort. The optimal cutoffs as well as their performance in real‐world patients require future study. To effectively risk‐stratify real‐world patients in an intention‐to‐screen fashion, future studies of multimodal approaches, including our risk score and other modalities such as the EncephalApp and the animal naming test, are indicated. Ridola and Riggio raised three additional issues that deserve clarification. First, validation: we performed an internal validation using a bootstrapping method. Second, we excluded patients with a history of overt HE at baseline. Our goal was to predict incident overt HE and not recurrent HE as patients with a history of overt HE are known to be at high risk of recurrent HE. Third, albumin levels can vary and are subject to confounding by malnutrition and ascites. We agree. However, both malnutrition (associated with sarcopenia or zinc deficiency) and ascites (an indicator of severe portal hypertension) are also expected to be associated with the risk of HE.
Idiotype Vaccination Using Dendritic Cells After Autologous Peripheral Blood Stem Cell Transplantation for Multiple Myeloma—A Feasibility Study
Authors: Volker L. Reichardt, Craig Y. Okada, Arcangelo Liso, Claudia J. Benike, Keith E. Stockerl-Goldstein, Edgar G. Engleman, Karl G. Blume, Ronald Levy
Journal: Blood (1999)
Medical ethics' assault upon medical values
Authors: C. D. Clements
Journal: JAMA (1983)

THE VIGOROUS resurgence of interest in medical ethics during the past two decades has created a large and controversial literature. Especially problematic is the application of medical ethicists' views in clinical settings. Physicians are decidedly ambivalent about these ethical contributions; on the one hand, they are eagerly searching for assistance in resolving the increasingly complex ethical dilemmas now so common in medical practice. On the other hand, they are wary and disappointed because, until now, the ethicists' contributions have been of dubious value. In this article we will argue that the currently dominant school in medical ethics, that of a patient autonomyrights model based in rationalist philosophy and liberal political theory, has been used to subvert values intrinsic to medicine, that it has done so without adequately establishing the merits of its case, and that the unfortunate result has been the attempted replacement of the historic medical value system by
Association News
Journal: JAMA (1935)

<h3>MEDICAL BROADCASTS</h3><h3>Columbia Broadcasting System</h3> The American Medical Association broadcasts on a western network of the Columbia Broadcasting System each Thursday afternoon on the Educational Forum from 4: 30 to 4:45 Chicago daylight saving time (3:30 p. m. central standard time). The next three broadcasts will be delivered by Dr. W. W. Bauer. The titles will be as follows: May 16. Children's Eyes. May 23. Saving Our Eyesight. May 30. Eye Accident Prevention. <h3>National Broadcasting Company</h3> The American Medical Association broadcasts under the title "Your Health" on a Blue network of the National Broadcasting Company each Tuesday afternoon from 4 to 4:15 Chicago daylight saving time (3 p. m. central standard time). The next three broadcasts will be as follows: May 14. Training Good Doctors, W. D. Cutter, M.D. May 21. Pain, W. W. Bauer, M.D. May 28. Problems of American Medicine, Morris Fishbein, M.D. <h3>Broadcast, May 11, in Commemoration</h3>
MUSICAL TALENT AND DEGENERACY.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Section 9.—Progressive Systemic Sclerosis (Scleroderma)
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Manuscripts Approved for JNCI, July 10 to August 10, 1964
Journal: JNCI Journal of the National Cancer Institute (1964)

Manuscripts Approved for JNCI, July 10 to August 10, 1964 Get access JNCI: Journal of the National Cancer Institute, Volume 33, Issue 3, September 1964, Page 589, https://doi.org/10.1093/jnci/33.3.589 Published: 01 September 1964
Expression of HMGA2 In Blood Cells From Patients with Paroxysmal Nocturnal Hemoglobinuria
Authors: Yoshiko Murakami, Norimitsu Inoue, Tsutomu Shichishima, Hideyoshi Noji, Jun-Ichi Nishimura, Yuzuru Kanakura, Taroh Kinoshita
Journal: Blood (2010)
PATHOLOGISTS IN HOSPITALS FOR INSANE.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Laparoscopy
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
LETTER FROM PARIS.
Authors: None A. B.
Journal: JAMA (1890)

(FROM OUR REGULAR CORRESPONDENT.) <i>La Grippe—Contagiousness of Tuberculosis — Professor Tarnier</i>. The present epidemic of influenza or la grippe has caused a great scare in Paris, not from its lethality but from the rapidity of its extension, affecting all classes of the population. It has even tried the wits of the doctors, who have been quite perplexed as to the real nature of the malady, some looking upon it as dengue, although in many respects they recognized the symptoms in it of an affection familiarly known to them as la grippe. The subject has even been discussed at the Academy of Medicine, and at a recent meeting Dr. Proust read a report on a work by Dr. Lebrun, of Bayreuth, on the epidemic of dengue which recently prevailed in the Levant, which, when compared with the present epidemic of Paris, will be found to be quite a different affection. Dengue
Male fertility preservation (FP) at pediatric cancer centers: A report from the Children’s Oncology Group (COG).
Authors: Jennifer Levine, Julienne Brackett, Brooke Cherven, Natasha Frederick, James L. Klosky, Sameeya Ahmed-Winston, Elyse Bryson, Joanne Frankel Kelvin, Gwendolyn P. Quinn, Lillian R. Meacham, David Robert Freyer, Christopher C. Dvorak, Eric Jessen Chow
Journal: Journal of Clinical Oncology (2019)

10050 Background: Preserved fertility after cancer is a priority for male survivors and their families. Sperm banking (SB) before initiation of treatment is standard of care for post-pubertal males. Experimental testicular tissue cryopreservation (TTC) is the only current option for pre-pubertal boys. ASCO recommends TTC be carried out under an experimental protocol. We surveyed COG sites about their FP infrastructure and practices. Methods: A REDcap survey was emailed to one individual previously identified as knowledgeable about FP or the Principal Investigator at each COG site. Site specific factors associated with outcomes were determined using logistic regression. All study procedures were IRB-approved. Results: Responses were received from 144 of 220 institutions (65%). Discussions about fertility were reported as routinely held with all post-pubertal males, all males “at risk” of infertility, and all males at 108 (75%), 100 (69%), and 55 (38%) institutions, respectively. SB was available at 135 (94%) sites; 105 (73%) offer SB inpatient and outpatient, 88 (64%) offer SB to all post-pubertal males, and 39 (28%) offer SB after chemotherapy has started. TTC was accessible at 37 (27%) sites and was independently associated with large (&gt;120 new patients/year) size (odds ratio [OR] 3.3 95% confidence interval [CI] 1.2-9.3), and the presence of a FP navigator/team [OR 3.3 CI 1.4-7.8). Seventeen sites (12%) offered TTC by referring elsewhere, 14 (10%) under an IRB protocol and 6 (4%) as a clinical service. Conclusions: SB is widely available across participating COG sites, however only 2/3 of sites offer banking to all post-pubertal males. The availability of TTC at treating institutions is quite limited. This access may be modifiable given the association of an established FP navigator/team with the ability to offer and/or refer patients to outside institutions for TTC. There are practices, such as SB after the start of treatment and offering TTC as a clinical service, that do not align with guideline recommendations. These survey results suggest FP services remain inadequate in this patient population and highlight opportunities for research leading to interventions.
Pneumomyelography
Authors: B. S. Epstein
Journal: JAMA (1969)

In summarizing his work on over 2,000 pneumomyelograms, Dr. Jirout concludes that pneumomyelography is the procedure of choice for contrast examinations of the spinal canal. He notes that body-section roentgenography and subtraction techniques are helpful, but apparently makes little use of these methods. Separate techniques are detailed for examination of the neural canal in the lumbar, thoracic, and cervical regions. Spinal-canal block is not regarded as a contraindication to pneumomyelography. Although he performs the examination with the patient sitting when a block is present, others, myself included, avoid draining the canal below a block for fear of downward plunge of the tumor. That this has not occurred during pneumomyelography shows that perhaps such fears are unfounded. Ordinarily the examination takes 1 1/2 hours, but complicated problems require 2 hours or more. It is stated that the patients suffer little pain or ill effects. Dr. Goree's translation is clear and the