tbuckley/cabot-search huggingface dataset:
TUBERCULOPHOBIA IN FRANCE.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A RECENT OUTBREAK OF TYPHUS FEVER IN LONDON.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A new twist
Authors: R. H. de Jong
Journal: JAMA (1977)

That medical research need not always originate in the laboratory is smartly illustrated by a recent article in the<i>Archives of Surgery</i>(112:685-688, 1977), where Duke and Yar report on "Primary Small Bowel Volvulus." Small bowel volvulus—torsion of the bowel on its mesentery—ordinarily results from congenital anomalies or postoperative adhesions. In the absence of these predisposing factors, primary volvulus is seldom encountered by Western surgeons. Likewise, the disorder is rarely encountered in Afghanistan. Rarely, that is, except for the holy month of Ramadan, when Mohammedans abstain from oral intake during daylight hours. Then, when darkness falls, the faithful take a large single meal. During that month, the incidence of primary small bowel volvulus rose more than tenfold; from less than one case per month (seven in 11 months) to nine or ten cases per month (in 1971 and 1970, respectively). Intriguing here is that volvulus occurred in males only; 25
Peripheral Vascular Disease in Circulation and the Circulation Subspecialty Journals
Journal: Circulation (2012)

The following articles are being highlighted as part of Circulation's Topic Review series. This series will summarize the most important manuscripts, as selected by the editors, published in Circulation and the Circulation subspecialty journals. The studies included in this article represent the articles related to peripheral vascular disease that were published in Circulation and the Circulation subspecialty journals in 2010 and 2011.
Export of intracellular HBsAg in chronic hepatitis B virus infection is related to viral replication
Authors: J Lau
Journal: Hepatology (1991)

Serum and liver HBsAg bear an inverse relation to each other during the evolution of chronic hepatitis B virus infection and the quantity of HBsAg in tissue rises gradually with time. In this study, intracellular and extracellular levels of HBsAg were measured by radioimmunoassay in primary culture of hepatocytes from 30 patients with chronic hepatitis B virus infection to determine a possible relationship with hepatitis B virus replication. Serum levels of HBsAg correlated with markers of active viral replication (serum hepatitis B virus DNA, p < 0.005, and tissue HBcAg, p < 0.02) but inversely with tissue HBsAg (p < 0.05). In similar fashion, in vitro export of HBsAg was also related to the presence of active viral replication markers (serum hepatitis B virus DNA, p < 0.02, and tissue HBcAg, p < 0.05) and negatively with tissue HBsAg (p < 0.001). Export of HBeAg also correlated positively with markers of active viral replication (serum hepatitis B virus DNA, p < 0.05 and tissue HBcAg, p < 0.05). Further experiments indicated that intrahepatic pre-S1 and pre-S2 correlated closely with intrahepatic HBsAg, indicating that a failure to export HBsAg was unlikely to be attributable to deficient intracellular expression of pre-S1 or pre-S2. These data indicate that in vitro primary hepatocyte culture of hepatitis B virus—infected cells provides an accurate reflection of in vivo export of HBsAg and that this is closely related to the presence of active viral replication.
Massachusetts Department of Public Health
Authors: Robert A. MacCready
Journal: New England Journal of Medicine (1951)

A PILOT MASS BLOOD-TYPING PROGRAMA pilot mass blood-typing program has been conducted this summer by the Massachusetts Civil Defense Agency under the technical supervision of the Diagnostic Laboratory of the Massachusetts Department of Public Health. Because the need for blood transfusions to save the lives of the injured would be tremendous in the event of an atomic disaster, the Blood Section of the Civil Defense Agency, headed by physicians thoroughly familiar with blood-transfusion problems, urged such a project. The purpose of the program was to ascertain the cost and feasibility of mass typing and at the same time to . . .
THE THERAPY OF THE COOK COUNTY HOSPITAL
Authors: BERNARD FANTUS
Journal: JAMA (1934)

<h3>THERAPY OF TETANUS</h3><h3>PROPHYLAXIS</h3><h3>1. Medical, Surgical and Obstetric Asepsis.—</h3> Tetanus has followed infection from hypodermic injection, especially of tissue-destroying drugs (such as quinine) and if made into the lower extremity. It has occurred also after vaccination. Infection may occur from blisters on the feet, from the umbilicus in the new-born infant, from bed sores contaminated by feces, and from burns. Wound discharges of patients with tetanus are infectious; hence care must be taken to prevent inoculation of others. Even though in actual practice such transmission is rare, patients with tetanus are best treated by a special nursing and medical group, trained to give constant and adequate care. <h3>2. Treatment of Contaminated Wounds.—</h3> Under local or general anesthesia, as needed, the wound should be incised, if this is required, to remove all foreign bodies (dirt, clothing, bone denuded of periosteum). Cleansing with soap and water, should be followed
Secondary hemochromatosis as a long‐term complication of the treatment of hematologic malignancies
Authors: Stuart M. Lichtman, Lori Attivissimo, Ira S. Goldman, Michael W. Schuster, Aby Buchbinder
Journal: American Journal of Hematology (1999)

The increased cure rate of hematologic malignancies including the use of bone marrow transplantation has focused attention on the chronic toxicity and quality of life of the survivors. We have observed five patients who have been diagnosed with clinically significant iron overload, presumably due to packed red blood cell transfusions, ≥12 months after transplant for a hematologic malignancy. In these patients, there is no history of veno-occlusive disease or family history of hemochromatosis. The allotransplant patient has been free of chronic graft versus host disease. Family screening has been negative. No patient developed clinically significant endocrinopathy, arthropathy, or cardiac disease. The patients have been treated with phlebotomy to bring the transferrin saturation and ferritin levels to normal. The long-term follow-up of patients treated for a hematologic malignancy should include analysis of hepatitis C virus and iron status. This may prevent the development of clinically significant chronic liver disease and possibly malignancy. Am. J. Hematol. 61:262–264, 1999. © 1999 Wiley-Liss, Inc.
The role of the Runx transcription factors in thymocyte differentiation and in homeostasis of naive T cells
Authors: Takeshi Egawa, Robert E. Tillman, Yoshinori Naoe, Ichiro Taniuchi, Dan R. Littman
Journal: The Journal of Experimental Medicine (2007)

Members of the Runx family of transcriptional regulators are required for the appropriate expression of CD4 and CD8 at discrete stages of T cell development. The roles of these factors in other aspects of T cell development are unknown. We used a strategy to conditionally inactivate the genes encoding Runx1 or Runx3 at different stages of thymocyte development, demonstrating that Runx1 regulates the transitions of developing thymocytes from the CD4−CD8− double-negative stage to the CD4+CD8+ double-positive (DP) stage and from the DP stage to the mature single-positive stage. Runx1 and Runx3 deficiencies caused marked reductions in mature thymocytes and T cells of the CD4+ helper and CD8+ cytotoxic T cell lineages, respectively. Runx1-deficient CD4+ T cells had markedly reduced expression of the interleukin 7 receptor and exhibited shorter survival. In addition, inactivation of both Runx1 and Runx3 at the DP stages resulted in a severe block in development of CD8+ mature thymocytes. These results indicate that Runx proteins have important roles at multiple stages of T cell development and in the homeostasis of mature T cells.
Protective effect of hepatocyte growth factor on interferon-gamma-induced cytotoxicity in mouse hepatocytes
Authors: M MORITA
Journal: Hepatology (1995)

We examined the interactive effect of several cytokines (interleukin-1 beta [IL-1β], tumor necrosis factor alpha [TNF-α], interferon gamma [IFN-γ], IL-6, IFN-α/β, and hepatocyte growth factor [HGF]) presumably involved in hepatitis, on primary cultured murine hepatocytes. Among these cytokines, only IFN-γ induced LDH release from hepatocytes in both time- and dose-dependent fashions. The cytotoxic effect was inhibited by antiserum-containing anti-mouse IFN-γ monoclonal antibodies (R4–6A2). Moreover, intriguingly, IFN-γ induced DNA fragmentation in the hepatocytes in a time- and dose-dependent fashion according to the gel electrophoresis of genomic DNA and flow cytometry analysis. These results suggest that the cytotoxic effect of IFN-γ on hepatocytes was caused by inductive apoptosis. The LDH release and DNA fragmentation induced by IFN-γ were inhibited by HGF in a dose-dependent manner, whereas they seemed to be accelerated by TNF-α. Flow cytometry analysis of the nuclei of treated hepatocytes confirmed the interactions in DNA degradation. The DNA synthesis of cultured hepatocytes was also reduced by IFN-γ but recovered by hepatocyte growth factor. Taken together, IFN-γ is presumed to be a critical cytokine in hepatic damage, and the network composed of IFN-γ, TNF-α, and HGF may play an important role in the regulation of liver injury.
Relation of allied health education to medical education
Authors: A. Pascasio
Journal: JAMA (1970)

A team is a group of competent individuals called team members. To function as a team, all members must know their own specific roles as well as the specific roles of others on the team. They also must know how all of the roles relate. In other words, they must understand what transforms a group of individual players into a team that functions smoothly in pursuit of its common goal. Teams allow for individual and group practice. Members are provided opportunities to master their own specific skills. They also are provided opportunities to practice their specific roles and skills as a team so that they learn not only how they<i>should</i>work together but also how<i>to</i>work together. If we truly believe that there is— or that there should be—a health team, should we not follow similar steps in the education of that team? We already provide opportunities for
Primary Erythermalgia
Authors: D. Alarcon-Segovia
Journal: JAMA (1968)

<h3>To the Editor:—</h3> Although the main causes of erythermalgia were apparently ruled out in the case reported by Pepper which responded to methysergide maleate treatment (<b>203</b>:1066, 1968), the possibility of one of the "primary" diseases later developing should be kept in mind. Although both the severity of the syndrome in the patient he reports, as well as the fact that it extended up both legs, suggests that the erythermalgia was, in this patient, primary. Its late and abrupt onset might indicate otherwise (<i>Circulation</i><b>29</b>:136, 1964). In our experience, a short followup is insufficient to label erythermalgia "primary." In one case previously reported (<i>Arch Intern Med</i><b>112</b>:688, 1963), onset of erythermalgia was followed in six months by appearance of systemic lupus erythematosus, and in eight others it preceded for as long as 16 years the detection of a myeloproliferative disorder, polycythemia vera in seven, and agnogenic myeloid metaplasia
Correction: Lifelong exercise and stroke
Journal: BMJ (1993)

Public health implications * Most women in developed countries are now offered screening for neural tube defects and affected babies are less common * Ascertainment of all births and terminations of pregnancy affected by neural tube defects in South Australia shows that the total prevalence remained stable during 1966-91 * Birth prevalence, however, fell by 84% as a result of screening * Serum a fetoprotein concentration and ultrasonography detected 85% of affected pregnancies before 28 weeks' gestation * Coordinated population based screening pro- grammes and registers of birth defects allow accurate assessment of effectiveness of prenatal diagnosis and preventive measures
CONTRACT PRACTICE AND ETHICS.
Journal: JAMA (1883)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Trauma
Authors: Robert J. Baker
Journal: JAMA (1982)

An increasingly popular form of reference volume is epitomized by this work, the first of several in this series to be produced by the authors. A variety of contributors from the United States and abroad have written overviews of the more problematic areas in trauma care and those with newer concepts in management. The editors have not been major contributors themselves, but have obviously carefully compiled the 17 chapters. The greatest assets of this type of text are the compact form, readability, and, of course, relatively low cost. The authors chosen are those with ample credentials to qualify as experts in the field, and they have an obvious ability to communicate. Six chapters are followed by commentary from equally acknowledged leaders in trauma, offering a nice counterpoint to the major view expressed in the adjacent chapter. The editors indicate that this volume is designed to keep both surgical house officers
The uncertainties surrounding carotid endarterectomy
Authors: H. J. Barnett
Journal: JAMA (1992)

The year 1991 must rank as a vintage year for all physicians who care for patients at risk of ischemic stroke. Three of the most prestigious medical journals with the widest circulation published the results of multicenter trials that determined an unequivocal benefit of carotid endarterectomy for patients experiencing symptoms due to severe carotid artery disease.<sup>1-3</sup> In these trials, surgery was compared with medical therapy: patients with recent focal symptoms in the brain or retina supplied by a stenosed carotid artery were randomly assigned to receive the best contemporary medical care alone or the same treatment with surgery added. Patients were not eligible if they had evidence of serious heart disease, other organ failure, or malignancy. One study was stopped after 3 years for patients with 70% stenosis or greater (defined as "severe") because of a clear difference in stroke-free survival between the medical and surgical groups.<sup>1</sup>Patients
BENJAMIN WATERHOUSE (1754-1846)—THE AMERICAN JENNER
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
DEATHS OF PHYSICIANS IN 1908
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Deserved Honor.—
Journal: JAMA (1891)

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Gynecologic Oncology
Authors: Michael Newton
Journal: JAMA (1982)

This 487-page book contains 19 chapters about the treatment of cancer of the female genital tract. Each chapter is preceded by a brief introduction and contains two (occasionally one or three) "perspectives" or articles on the topic under discussion. The editor's introduction and the first chapter by John L. Lewis deal at length with the emergence of the specialty of gynecologic oncology and the role of the gynecologic oncologist. Two chapters cover cancer of the vulva, three cancer of the cervix, two cancer of the endometrium, five cancer of the ovary, and one gestational trophoblastic disease. Other chapters are "The Effects of DES," "The Statistical Evaluation of Clinical Trials in Cancer: Use and Misuse," "Tumor Immunology," "Ovarian Conservation in Patients Undergoing Pelvic Irradiation," and "The Gynecologic Oncology Nurse." There is much useful information in this book, and the references are adequate and up to date. However, it suffers from repetitiveness,
Implications of methadone maintenance for theories of narcotic addiction
Authors: V. P. Dole
Journal: JAMA (1988)

Clinical success in rehabilitation of heroin addicts with maintenance treatment requires stability of the blood level in a pharmacologically effective range (optimally, 150 to 600 ng/mL)—a phenomenon that emphasizes the central importance of narcotic receptor occupation. It is postulated that the high rate of relapse of addicts after detoxification from heroin use is due to persistent derangement of the endogenous ligand-narcotic receptor system and that methadone in an adequate daily dose compensates for this defect. Some patients with long histories of heroin use and subsequent rehabilitation on a maintenance program do well when the treatment is terminated. The majority, unfortunately, experience a return of symptoms after maintenance is stopped. The treatment, therefore, is corrective but not curative for severely addicted persons. A major challenge for future research is to identify the specific defect in receptor function and to repair it. Meanwhile, methadone maintenance provides a safe and effective way to normalize the function of otherwise intractable narcotic addicts. (<i>JAMA</i>1988;260:3025-3029)