tbuckley/cabot-search huggingface dataset:
The New York State Examination Act.
Authors: William Warren Potter
Journal: JAMA (1890)

<h3>To the Editor:</h3> —In view of Dr. Carroll's letter inThe Journalof September 13, 1890, it would seem proper for me to add a final word, which I promise shall be the last. As I did not, in my letter of August 30, attempt to defend the Act in question, but did point out the misrepresentations of Dr. Carroll in regard to the Medical Society of the State of New York, which any one unprejudiced could readily see was the sole purpose of my communication, it is difficult to understand how he can say that I misapprehend "both the intention of my [his] criticism and the act which he defends." When a man of presumed information asserts that there was a time in its history when but "two [members] per annum out of the many 'eligibles' could be elected" in the Society in question, there would appear to be
A New Crop of Concerns Congress Investigates Pesticide Safety
Authors: David A. Taylor
Journal: Environmental Health Perspectives (2000)

completed an analysis requested in 1998 by Representatives Tom Lantos (D-California), Henry Waxman (D-California), and Bernard Sanders (I-Vermont), long-time proponents of farmworker safety.The report comes at a time when questions about children's vulnerability to pesticide-related health risks are mounting in
POW-turned-physician pilots revised course
Authors: D. E. Riesenberg
Journal: JAMA (1986)

A physician now working in South Carolina is among those persons who can discuss torture from the personal perspective of having been its victim. Nearly 20 years ago, on Sept 4, 1966, Thomas M. McNish—then a fighter pilot in the US Air Force and still a professional military officer—was shot down over North Vietnam while approaching a target 12 miles from Hanoi, the capital. He ejected from his F-105 "Thunderchief" jet fighter-bomber at a speed of more than 500 miles per hour. For the next 6 1/2 years, McNish was held captive by the North Vietnamese. While a prisoner, he was a victim of torture. After his release, he attended medical school and completed a residency in family medicine. Still in the Air Force and now a lieutenant colonel, McNish is commander of the military hospital on the base at Myrtle Beach, SC. He recently talked to MEDICAL NEWS &amp;
Reply
Authors: J. Ferguson, B. E. Johnson
Journal: British Journal of Dermatology (1986)

Journal Article Reply Get access J. Ferguson, J. Ferguson Department of Dermatology, Ninewells Hospital, Dundee DD2 9SY, U.K. Search for other works by this author on: Oxford Academic Google Scholar B. E. Johnson B. E. Johnson Department of Dermatology, Ninewells Hospital, Dundee DD2 9SY, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 115, Issue 2, 1 August 1986, Page 254, https://doi.org/10.1111/j.1365-2133.1986.tb05733.x Published: 01 August 1986
Case 6-2012: A 45-Year-Old Man with a History of Alcohol Abuse and Rapid Cognitive Decline
Authors: Seth Seabury, Santa Monica, Amitabh Chandra, Darius Lakdawalla, Anupam Jena
Journal: New England Journal of Medicine (2012)

all specialties, but there was still significant variation (from $7,283 in nephrology to $25,073 in gynecology).The correlation between mean costs in claims with and without payments was small and positive (0.39).These findings show that although the costs of dispute resolution are higher for claims that result in indemnity payments, there is still a meaningful cost of resolving claims that never result in payment.Moreover, there is substantial variation in these costs across specialties, though this variation is not necessarily the same as the variation in the frequency or size of claims.Lowering the costs of dispute resolution could lead to considerable savings for physicians and insurers, particularly in specialties with high mean defense costs.
ABSTRACTS
Journal: Circulation (1961)

Findings at necropsy on a 16-year-old female baboon that died of infection in a North Ameri- can zoo revealed many atheromata in the lower part of the abdominal aorta, similar to the lesions of atherosclerosis in the human.Because baboons may have a higher incidence of atherosclerosis than had been suspected for most primates and because these lesions may develop in the absence of excessive dietary cholesterol, a study was under- taken to determine the precise incidence of ar- terial lesions in baboons that had lived in their natural habitat.Study was made of 163 such animals immediately after they were trapped in Kenya, British East Africa.Some deposition of lipid was found in the intima of the aorta in approximately three fourths of the 67 adults, and this was extensive in a few animals.No sex differ- ence was observed.Electron microscopy disclosed that most of the lipid droplets in the intima were intracellular.Fibrous plaques were infrequent.However, in one elderly male they were noted, and hemorrhage had occurred into the bases of the plaques.Sections of coronary arteries showed many small musculo-elastic intimal plaques in which lipids could be demonstrated only rarely.The aortic lesions occurred in the absence of exoess intake of animal fat or hypercholester- emia.It was suggested that the baboon is highly susceptible to lipid deposition in the arterial in- tima and, therefore, that it will lend itself well to the experimental study of atherosclerosis.SCHIRGER Robertson, J. H.: The Influence of Mechanical Factors on the Structure of the Peripheral Arteries and the Localization of Atherosclerosis.J. Clin.Path. 13: 199 (May), 1960.The peripheral arteries of 81 subjects, ranging in age from 1 month to 95 years, were examined at necropsy.No hypertension was evident clini- cally or at necropsy in the group.The radial artery at the wrist was examined in 65 cases, and segments obtained from the brachial artery, the upper third of the femoral artery, from the popliteal artery, and from the posterior tibial artery.Three changes were seen to occur in the structure of the peripheral vessels during the first two decades of life.During the first decade the only change observed was some increase in size of the muscular cushions previously observed in the popliteal and lower end of the brachial artery of the fetus.By the end of the second decade further cushions had formed at the mouths of branches in other peripheral vessels, partic- uarly the femoral artery.These cushions were less prominent in the radial and posterior tibial ar- teries.Simultaneously, with the development of
Serum cholinesterase, an underestimated marker in the prediction of acute-on-chronic liver failure, organ failure and LTx-free survival in patients with liver cirrhosis?
Authors: Tammo Lambert Tergast, Abdul-Rahman Kabbani, Marie Schultalbers, Michael P. Manns, Markus Cornberg, Benjamin Maasoumy
Journal: Journal of Hepatology (2020)
BELGIUM
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Spontaneous postpartum regression of pituitary mass with return of function
Authors: S. Leiba
Journal: JAMA (1986)

A 37-year-old woman undergoing endocrine evaluation during her seventh pregnancy because of headaches, weakness, and hyponatremia was found to have central hypoadrenalism and hypothyroidism. Computed tomography showed a pituitary mass with suprasellar extension but her visual fields were intact. She was treated conservatively with hydrocortisone acetate and levothyroxine sodium until 38 weeks of gestation, when healthy twins were delivered by cesarean section. A few months later, her pituitary function improved, with a significant increase in the adrenocorticotropic hormone level, normal values of basal thyroid-stimulating hormone, growth hormone, and gonadotropins and of their functional reserves, and only a slight elevation in the prolactin level. A repeated computed tomographic scan showed disappearance of the pituitary mass. (<i>JAMA</i>1986;255:230-232)
Correction: Quantifying underreporting of law-enforcement-related deaths in United States vital statistics and news-media-based data sources: A capture-recapture analysis
Authors: Justin M. Feldman, Sofia Gruskin, Brent A. Coull, Nancy Krieger
Journal: PLoS Medicine (2017)

The fourth sentence in the fourth paragraph of the Discussion section is incorrect.The correct sentence is: Second, Lum and Ball [29], adjusting for potential list dependency but not for agency nonresponse, used the same BJS data to estimate an annual mean of 1,250 deaths in the US, which is higher than our estimate.
The Clinical Introduction of Genetic Testing for Alzheimer Disease&lt;subtitle&gt;An Ethical Perspective&lt;/subtitle&gt;
Authors: Stephen G. Post
Journal: JAMA (1997)

<h3>Objective.</h3> —Primary caregivers should be aware of recent progress in the genetics of Alzheimer disease (AD) and of the clinical and ethical considerations raised regarding the introduction of genetic testing for purposes of disease prediction and susceptibility (risk) analysis in asymptomatic individuals and diagnosis in patients who present clinically with dementia. This statement addresses arguments for and against clinical genetic testing. <h3>Participants.</h3> —The 20 participants were selected by the investigators (S.G.P., T.H.M., A.B.Z., and P.J.W.) to achieve balance in the areas of genetics, counseling, ethics, and public policy, and to include leadership from related consensus projects. The consensus group met twice in closed meetings and carried on extensive correspondence over 2 years (1995-1997). The project was supported by the National Human Genome Research Institute of the National Institutes of Health. <h3>Evidence.</h3> —All 4 involved chromosomes were discussed in group meetings against a background of information from several focus group sessions with AD-affected families. The focus groups comprised volunteers identified by the Cleveland Area Chapter of the Alzheimer's Disease and Related Disorders Association and represented a variety of ethnic populations. <h3>Consensus Process.</h3> —The first draft was written in April 1996 by the principal investigator (S.G.P.) after the consensus group had met twice. The draft was mailed to all consensus group members 3 times over 6 months for extensive response and redrafting by the principal investigator until all members were satisfied. <h3>Conclusions.</h3> —Except for autosomal dominant early-onset families, genetic testing in asymptomatic individuals is unwarranted. Use of<i>APOE</i>genetic testing as a diagnostic adjunct in patients already presenting with dementia may prove useful but it remains under investigation. The premature introduction of genetic testing and possible adverse consequences are to be avoided.
Orthopaedic Surgery
Authors: Leonard F. Peltier
Journal: JAMA (1964)

In the preparation of this sixth edition of<i>Orthopaedic Surgery</i>, Sir Walter Mercer has been joined by Robert B. Duthie of Rochester, N.Y. With such a collaboration the book loses much of its insular quality and becomes a more suitable textbook for students and physicians throughout the English-speaking world. Within the compass of little more than 1,000 pages the authors have presented what they believe to be the essential elements of the anatomy, physiology, pathology, pathogenesis, diagnosis, and treatment of diseases of the musculoskeletal system. A tremendous amount of material is presented. The illustrations, line drawings, and radiographs are generally good. Some of the terminology, ie, epiphyseal coxa vara, may be confusing, while in an English text book one is surprised to find "sprung back," as a diagnosis. The references to the literature are not very numerous and will not be particularly useful to the reader as a guide to
THE PHYSICIAN'S PRIVATE DIAGNOSTIC LABORATORY.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hereditary galactosemia
Authors: R. G. Hansen
Journal: JAMA (1969)

Galactosemia results from a hereditary defect of the galactose-1-phosphate uridyl transferase enzyme, which is necessary for proper metabolism of the sugar, galactose (Fig 1). This molecular disease provides a useful model for the consequences of mutations in humans which alter gene, function. Molecular disease, as a concept, is not new, but progress in understanding these inborn enzyme defects has been striking during the last decade.<sup>1</sup>The advances made in the understanding of both the biochemistry and genetics of these hereditary diseases have resulted in improved medical practice. Galactosemia is a molecular disease which exemplifies the classical model of an autosomal-recessive disorder.<sup>2,3</sup>Because human erythrocytes reflect the pathways of metabolism of galactose, they have been a convenient source of tissue for biochemical and genetic analysis.<sup>4</sup>By chemical manipulation of isolated erythrocytes the occurrence of galactosemia can be determined with certainty and heterozygotes or carriers from both the diseased
The phenotype of compound heterozygous BSEP deficiency patients is determined by the combined residual function of the two ABCB11 mutations: results from the NAPPED consortium
Authors: Antonia Felzen, Daan van Wessel, Richard Thompson, Emmanuel Gonzales, Irena Jankowska, Etienne Sokal, Tassos Grammatikopoulos, Agustina Kadaristiana, Emmanuel Jacquemin, Anne Spraul, Patryk Lipiński, Piotr Czubkowski, Nathalie Rock, Mohammad Ali Shagrani, Dieter Clemens Broering, Talal Algoufi, Nejat Mazhar, Emanuele Nicastro, Deirdre Kelly, Gabriella Nebbia, Henrik Arnell, Björn Fischler, JBF Hulscher, Daniele Serranti, Cigdem Arıkan, Esra Polat, Dominique Debray, Florence Lacaille, Cristina Gonçalves, Loreto Hierro, Gema Muñoz Bartolo, Yael Mozer Glassberg, Amer Azaz, Jernej Brecelj, Antal Dezsőfi, Pier Luigi Calvo, Enke Grabhorn, Ekkehard Sturm, Wendy van der Woerd, Binita M. Kamath, Jian-She Wang, Li Liting, Ozlem Durmaz, Nanda Kerkar, Marianne Hørby Jørgensen, Ryan Fischer, Carolina Jimenez-Rivera, Seema Alam, Mara Cananzi, Mathias Ruiz, Cristina Targa, Felipe Ordoñez Ferrero, Heng Wang, Kyungmo Kim, Huey-Ling Chen, Elisa Carvalho, Bettina Hansen, Henkjan Verkade
Journal: Journal of Hepatology (2020)
TRYbeCA-1: A randomized, phase III study of eryaspase in combination with chemotherapy versus chemotherapy alone as second-line treatment in patients with pancreatic adenocarcinoma (NCT03665441).
Authors: Pascal Hammel, Rossana Berardi, Eric Van Cutsem, Jaime Feliu, Richard Greil, Harpreet Singh Wasan, Jean-Philippe Metges, Peter Nygren, Pia J. Osterlund, Marcus Smith Noel, Thomas Seufferlein, Geert-Yan Creemers, Anu Gupta, Sophie Salesse, Nigel Biswas-Baldwin, Hedy Dion, Hagop Youssoufian, Felix Tomas Garzon, Iman El-Hariry, Manuel Hidalgo
Journal: Journal of Clinical Oncology (2020)

TPS783 Background: Second-line treatment options for advanced pancreatic adenocarcinoma are currently limited. Eryaspase, asparaginase (ASNase) encapsulated in red blood cells (RBCs) is an investigational product under development. Following infusion, asparagine and glutamine are actively transported into RBCs where they are hydrolyzed by the encapsulated ASNase. We have recently reported the outcome of a randomized Phase 2b study inpatients with advanced pancreatic cancer whose disease progressed following first-line treatment. Eryaspase in combination with gemcitabine monotherapy or FOLFOX combination therapy improved overall survival (OS) and progression free survival (PFS). The safety profile of eryaspase was acceptable. The results of this Phase 2b study provided a rationale for initiating this confirmatory Phase 3 pivotal trial (TRYbeCA-1). Methods: TRYbeCA-1 is a randomized, open-label Phase 3 trial (N = ~500) of eryaspase combined with chemotherapy in patients with adenocarcinoma of the pancreas who have failed only one prior line of systemic anti-cancer therapy for advanced pancreatic cancer and have measurable disease. Patients are randomized in a 1:1 ratio to receive gemcitabine/Abraxane or irinotecan-based therapy (FOLFIRI [FOLinic acid-Fluorouracil-IRInotecan regimen] or irinotecan liposome injection/5-fluorouracil/leucovorin) with or without eryaspase, administered as IV infusion on Day 1 and Day 15 of each 4-week cycle. Key eligibility criteria include performance status 0 or 1; stage III-IV disease; documented evidence of disease progression; available tumor tissue; and adequate organ function. The primary endpoint is OS. Key secondary endpoints include PFS and objective response rate, safety, quality of life, pharmacokinetics and pharmacodynamics, and biomarker research. A hazard ratio in OS of 0.725 is being targeted which represents a conservative estimate based on the Phase 2b data and is viewed as being highly clinically relevant. An IDMC will be established to review safety at regular intervals andto review efficacy data at the planned interim and final analyses. Clinical trial information: NCT03665441.
SCIENCE IN EVERYDAY MEDICINE
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reversal of cimetidine-induced stupor by physostigmine
Authors: J. P. Fiore
Journal: JAMA (1979)

<h3>To the Editor.—</h3> In a recent article by Mogelnicki and associates (241:826, 1979) regarding the use of physostigmine in two patients to reverse a stupor that was apparently induced by the histamine H<sub>2</sub>antagonist cimetidine, the authors note two possible explanations for the observed events: First, physostigmine was acting specifically to reverse an anticholinergic stupor caused by cimetidine. Cimetidine would be classified with a wide variety of other drugs known to produce the central anticholinergic syndrome, which is manifested by stupor in severe cases. If physostigmine was reversing a central anticholinergic stupor produced by cimetidine, presumably at H<sub>2</sub>receptors in the CNS, the clinical manifestations of the anticholinergic syndrome in these two patients were unusual because the patients did not first manifest the usual initial mental changes associated with the central anticholinergic syndrome, such as delirium and agitation, before their conditions progressed to stupor. The second explanation of
Investigations on Malaria in Italy
Authors: None Celli
Journal: BMJ (1899)

I 95 sleep is associated with a retraction of the small protoplasmic prolongations and consequent interruption of contacts, are erroneous.He believes that the inter-neuronic suspension of contact is of quite secondary importance, and that tie cha- racteristic condition in natural sleep, as in that induced by chloroform, ether, or chloral, is a general expansiot of the gemmulm, with exhaustion of their contractility at the beginning and renewed capacity to contract at the end of sleep.
PEDIATRIC NURSE-PRACTITIONER PROGRAM
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal