tbuckley/cabot-search huggingface dataset:
Long-term treatment of refractory hypertensive patients with minoxidil
Authors: H. C. Mitchell
Journal: JAMA (1978)

Twenty-nine hypertensive patients refractory to conventional medications were treated continuously with minoxidil, sympathetic suppressants, and diuretics for six months to five years (mean, 30 months). All had evidence of hypertensive end-organ damage before minoxidil therapy. Good blood pressure control was obtained in 21 (72%) of 29 patients when minoxidil was given in dosages up to 40 mg/day. No tolerance was found. In the remaining eight, good control was obtained in three when phenoxybenzamine therapy was added, and in one when clonidine therapy was added. Renal failure requiring hemodialysis developed in five of 29, one had temporary hemiparesis, and one had fatal cerebral hemorrhage. In the remainder, myocardial infarctions and strokes were effectively prevented. Patients receiving minoxidil and propranolol hydrochloride had elevated plasma norepinephrine levels while those receiving clonidine had normal plasma norepinephrine levels. (<i>JAMA</i>239:2131-2138, 1978)
LETTER FROM PARIS. (FROM OUR OWN CORRESPONDENT.)
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Subclavian Angiography
Authors: F JAUNDRELL-THOMPSON
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Thoracic, abdominal, and peripheral trauma. Evaluation with angiography
Authors: H. C. Redman
Journal: JAMA (1977)

PROMPT evaluation of the condition of patients who have suffered penetrating or blunt trauma is important in reducing morbidity and mortality. During the past few years, many diagnostic tests have been developed to aid the clinician, and use of the appropriate ones is important in facilitating proper patient management. Angiography has a specific role in some injuries but should be held in reserve in others. Both the type of trauma and the severity of the injury are important in deciding when to use angiography. <h3>Penetrating Trauma</h3> Most patients who have had a penetrating injury to the thorax or abdomen with a high- or low-velocity missile will need surgical exploration, and generally there is no need for angiography. Occasionally, when there have been multiple injuries, angiography may be used to decide which injuries should be approached first. For example, a patient had been shot through the right forearm and back at
Sex and Gender Bias in Illustrations in Anatomy and Physical Diagnosis Texts
Authors: F. M. Brunemeier
Journal: JAMA (1995)

<h3>To the Editor.</h3> —The article by Ms Mendelsohn and colleagues<sup>1</sup>is not a scholarly work and should not have a place in a journal of scientific medicine. It is an exercise in tendentiousness of a sort that passes for scholarship in women's studies departments in trendy leftist universities where faculty, like the authors of this article, also seem to be preoccupied with victimhood and dedicated to the unending search for grievances about which to become outraged. The authors advance the thesis that since male figures are represented more often than female figures in anatomical diagrams, the message is conveyed that women are unimportant and only masculine anatomy is the norm, which is patently preposterous. A medical student simple-minded enough to arrive at that conclusion does not belong in medicine. They further speculate that a preponderance of male illustrations in anatomy texts ultimately results in female repression and emotional injury.
Education for a career in nursing
Authors: F. M. Alexander
Journal: JAMA (1966)

High school students considering careers in nursing frequently turn to their family physicians for advice. Specifically, they want to know about differences in the various types of educational programs in nursing, admission requirements, costs, and sources of scholarship or loan funds. This communication presents an overview of career information helpful to physicians and others frequently asked to advise young people in making decisions about careers in nursing. A previous report of the AMA Committee on Nursing<sup>1</sup>pointed out that there is considerable diversification in nursing education programs. Certain events have occurred since publication of that report which will in all probability affect the future of nursing. Some changes have already occurred as a result of the report of the Surgeon General's Consultant Group on Nursing, Toward<i>Quality in Nursing—Needs and Goals</i>.<sup>2</sup> Significant recommendations made by that consultant group will, in time, influence the quality of nursing care and
Postoperative surveillance recommendations for early-stage colon cancer based on results from the clinical outcomes of surgical therapy trial
Authors: V. L. Tsikitis, K. Malireddy, E. A. Green, B. Christensen, R. Whelan, J. Hyder, D. Lauter, P. Marcello, S. Larach, D. Sargent, H. Nelson
Journal: Journal of Clinical Oncology (2009)

4013 Background: Intensive postoperative surveillance is associated with improved survival and recommended for patients with late stage (stage IIB &amp; III) colon cancer. We hypothesized that stage I &amp; IIA colon cancer patients would experience similar benefits. Methods: Secondary analysis of data from the Clinical Outcomes of Surgical Therapy trial was performed by analyzing results according to TNM stage; early (stage I &amp; IIA; 537 patients) and late (stage IIB &amp; III; 254 patients) stage disease. Five-year recurrence rates were higher in patients with late (35.7%) versus early stage disease (9.5%). Early and late stage salvage rates, recurrence patterns and methods of first detection were compared by χ 2 test. Results: Salvage rates for early and late stage disease patients with recurrence were the same (35.9% versus 37%, p=0.9 respectively). Median survival following second surgery after recurrence was 35.8 months late stage and 51.2 months for early stage patients respectively. Sites of first recurrence did not significantly differ between late and early stage disease: liver (37.4% vs. 27.2%); lung (29.7% vs.23.6%); intraabdominal (24.2% vs.10.9%); and locoregional (12.1% vs.10.9%). Methods of first detection of recurrence were also not significantly different: CEA (37.4% vs. 29.1%); CT scan (26.4% vs. 23.6%); chest X-ray (12.1% vs. 7.3%); and colonoscopy (8.8% vs. 12.7%), for late versus early stage disease, respectively. Conclusions: Patients with early stage colon cancer have similar sites of recurrence, and receive similar benefit from post-recurrence therapy as later stage patients; implementation of existing surveillance guidelines for early stage patients is appropriate. No significant financial relationships to disclose.
COMPULSORY NOTIFICATION OF TUBERCULOSIS.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Contribution of hepatitis C virus to non-A, non-B fulminant hepatitis in Japan
Authors: M Yoshiba
Journal: Hepatology (1994)

To assess the contribution of hepatitis C virus to non-A, non-B fulminant hepatitis in Japan, we compared 10 major clinical features among 7 patients with type B fulminant hepatitis (type B group), 13 patients with non-A, non-B fulminant hepatitis with evidence of hepatitis C virus infection (type C group) and 10 patients without evidence of hepatitis C virus infection (NANB group). Duration from first symptom to coma and that from onset of jaundice to coma was significantly longer in the type C group (median = 39 and 25 days, respectively) and in the non-A, non-B group (median = 29 and 12 days, respectively) than in the type B group (median = 9 and 2 days, respectively) (p < 0.01). The maximum median AST level was significantly lower in the type C (1,689 U/L) and non-A, non-B groups (1,353 U/L) than in the type B group (5,780 U/L) (p < 0.05). Serum transaminase levels showed a single peak in six of seven of the type B patients, whereas they formed two or more peaks in all of the type C patients and in most of the non-A, non-B group (p < 0.05). Six of seven in the type B group, 6 of 13 in the type C group and 4 of 10 in the non-A, non-B group survived (p < 0.05). We found no significant difference in any of the 10 clinical features between the type C and non-A, non-B groups. Compared with type B fulminant hepatitis, type C and most cases of non-A, non-B fulminant hepatitis in Japan are, thus, characterized by slower and less severe but more persistent hepatocyte destruction. (HEPATOLOGY 1994;19:829–835.)
Quinidine-sulfate-induced hypoplastic anemia and agranulocytosis
Authors: U. S. Barzel
Journal: JAMA (1967)

QUINIDINE - Sulfate-induced thrombocytopenia has been reported and extensively studied.<sup>1,2</sup>Cases in which hemolytic anemia<sup>3</sup>or leukopenia<sup>4</sup>accompanied thrombocytopenia have also been reported. This communication reports the development of hypoplastic anemia and agranulocytosis<i>without thrombocytopenia</i>following quinidine therapy. <h3>Report of a Case</h3> A 36-year-old man (82064) was admitted to Montefiore Hospital and Medical Center on April 29, 1965, because of pancytopenia and fever. History revealed correction of strabismus at the age of 2 years, pneumonia at the age of 15, infectious mononucleosis at the age of 26, and varicose vein stripping from both lower extremities at the age of 27. There was no history of allergy, heart disease, or hematologic disorder. The family history was normal. On Nov 30, 1964, acute ventricular tachycardia developed that required direct-current shock conversion for control. He was given procainamide hydrochloride, 250 mg four times daily, in the hospital and after discharge. On
Global health interdependence and the international physicians' movement
Authors: G. A. Gellert
Journal: JAMA (1990)

International Physicians for the Prevention of Nuclear War has had an impressive public impact in the 1980s, helping to shatter the myths of surviving and medically responding to a nuclear attack. The 1990s present a new challenge for the medical community in a different social and international context characterized by increasing global interdependence. Another view of physician activism is presented to complement advocacy for nuclear disarmament in the promotion of peace. A framework for analysis is provided by "fateful visions"—accepted policy views of prospective superpower relations—drawn from practitioners of foreign policy, international relations, and security affairs. A perceptual gap may exist between physicians who wish to address underlying ethical and public health concerns on security issues and policy practitioners who are accustomed to discussion within existing policy frames of reference that can be pragmatically used. A strategy is proposed for physicians to use their specialized training and skills to evaluate trends in global health interdependence. The international physicians' movement may contribute substantively to the formulation of policy by expanding and interpreting an increasingly complex database on interdependence, and by creating a dialogue with policy formulators based on mutual recognition of the value and legitimacy of each professions' expertise and complementary contributions to international security policy. (<i>JAMA.</i>1990;264:610-613)
Palmoplantar Pustulosis Presenting With Chest Pain—Diagnosis
Journal: JAMA Dermatology (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Incorrect Figure Label
Authors: George Gellert, Ricardo Ramirez, Lvn Webster
Journal: JAMA (2015)

Penny F. Whiting, PhD; Robert F. Wolff, MD; Sohan Deshpande, MSc; Marcello Di Nisio, PhD; Steven Duffy, PgD; Adrian V. Hernandez, MD, PhD; J. Christiaan Keurentjes, MD, PhD; Shona Lang, PhD; Kate Misso, MSc; Steve Ryder, MSc; Simone Schmidlkofer, MSc; Marie Westwood, PhD; Jos Kleijnen, MD, PhD
By uniting we stand
Authors: W. W. Hall
Journal: JAMA (1971)

It is a gloomy moment in history. Not for years has there been so much apprehension. Never has the future seemed so incalculable. In France, the political caldron seethes.... Russia hangs like a cloud on the horizon.... All the resources of the British are sorely tried.... Of our problems here in the United States, no man can see the end.
Alteration of Topoisomerase II Action Is a Possible Molecular Mechanism of HL-60 Cell Differentiation
Authors: F. Gieseler, F. Boege, M. Clark
Journal: Environmental Health Perspectives (1990)

The inhibition of differentiation and persistence of proliferation in cell transformation is probably not only caused by the mutation of single genes. An additional mechanism of transcriptional control, not only of single genes but of gene programs, is possibly the alteration of the topoisomerases. These enzymes regulate the conformation of DNA by twisting and unwinding the double strands. As has been shown previously, only the genes located in relaxed DNA areas are transcribed and, therefore, the topoisomerases can be described as a gene regulation device. We present the hypothesis that topoisomerase II action is not only altered in, but also necessary for, HL-60 granulocytic cell differentiation. Thus, alteration of topoisomerases may well be a molecular mechanism of cellular differentiation.
Mortality Patterns—United States, 1993
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Injection Mammography
Authors: Ralph W. Wayne
Journal: JAMA (1977)

WITH THE advent of mammography and xeromammography, the occult nonpalpable lesion has created a new problem for both the surgeon and pathologist. A small lesion is usually difficult and sometimes impossible for the surgeon to locate at the time of biopsy and, therefore, frequently necessitates a large deforming biopsy to ensure removal of the lesion. If the lesion is benign, the patient is left with a permanent breast deformity. Several techniques have been advocated to assist in localizing the nonpalpable lesions.<sup>1-4</sup>The injection of a mixture of Evans blue dye or indocyanine green and radiopaque contrast material has proved to be a successful method in our series. A protocol (Fig 1) is recommended in the radiographic assessment of nonpalpable lesions of the breast. <h3>Method</h3> Several hours prior to surgery, two parts of a mixture of meglumine and sodium salts of diatrizoate (Renografin 60) was combined with one part of
Reply
Authors: Hossein Poutschi, Jacob George
Journal: Hepatology (2012)

We thank Rowe et al. for their commentary on the issue of informed consent in surveillance for hepatocellular carcinoma in patients with cirrhosis. Our publication1 examined the feasibility of conducting a randomized controlled trial (RCT) for liver cancer screening given current medical practice, patient attitudes, and knowledge in developed nations such as Australia. We fully concur that informed consent needs to outline both the risks and benefits of any surveillance program. To this end, above and beyond the patient information and consent form, we specifically developed a decision aid (DA) in plain English to help in the decision-making process. As outlined in the DA, the disadvantages of screening are discussed in Section 10 (Does screening improve the survival of patients with HCC) and in Section 12, where we ask participants to discuss the DA with the clinician involved and their family physician, including the risks and benefits, the convenience and discomfort from screening tests, and whether surveillance has been proven to reduce the risk of dying from cancer. Additionally, on the last page of the DA we diagrammatically represent the potential advantages and disadvantages of screening, including the inconvenience of clinic visits and ultrasounds and anxiety from false-positive results. Our consent process involved a 30-minute interview with the patient at which time we discussed all their concerns, including the risks and benefits of surveillance. Finally, based on a questionnaire of participants, 56% believed that the information provided was unbiased and nearly 80% thought that the information provided was adequate. Surveillance programs should outline the risks and benefits of the program, including any potential for physical or psychological harm; we believe that this was adequately done in our study. Whether the DA could have been improved is a judgment call, but we would contend that future similar studies can be similarly criticized, on the quality of the DA developed. Most important, we believe, based on our results, that patients in developed countries will elect to have screening, and further, that an RCT as suggested, while ideal, is highly unlikely to eventuate or to put this matter to rest, any more than the present study. Hossein Poutschi MBBS, PhD* , Jacob George MBBS, PhD, FRACP , * Digestive Disease Research Centre, Tehran University of Medical Science, Tehran, Iran, Storr Liver Unit, Westmead Millennium Institute, University of Sydney and Westmead Hospital, NSW, Australia.
Arteriovenous Malformations of the Brain in Adults
Authors: The Arteriovenous Malformation Study Group
Journal: New England Journal of Medicine (1999)

Modern imaging techniques are increasingly discovering arteriovenous malformations of the brain, many of which are still unruptured. Advances in microsurgery, endovascular techniques, and radiotherapy have expanded the options for therapy and have come at a faster pace than information on the natural history of arteriovenous malformations, the associated morbidity and mortality, and the risks of invasive therapies. This review focuses on arteriovenous malformations of the brain in adults; a recent publication dealt with arteriovenous malformations in children.1 AngioarchitectureArteriovenous malformations are a complex tangle of abnormal arteries and veins (Figure 1) linked by one or more fistulas. Arteriovenous malformations lack . . .
Stimulus Specific Responses from Beyond the Classical Receptive Field: Neurophysiological Mechanisms for Local-Global Comparisons in Visual Neurons
Authors: J Allman
Journal: Annual Review of Neuroscience (1985)

The brain's default mode network consists of discrete, bilateral and symmetrical cortical areas, in the medial and lateral parietal, medial prefrontal, and medial and lateral temporal cortices of the human, nonhuman primate, cat, and rodent brains. Its ...Read More