tbuckley/cabot-search huggingface dataset:
Pancreatitis
Authors: Dan W. Elliott
Journal: JAMA (1984)

This is a modest treatise of 120 pages on the main inflammatory conditions of the pancreas. The volume is edited by Dr Paloyan, but there are only three additional contributors: two radiologists and a surgeon. The radiologists, like Dr Paloyan, are members of the staff at Evanston (Ill) Hospital and the faculty at Northwestern University. The authorship of the individual chapters is not identified. The book is beautifully published with large type on glossy paper, which permits excellent reproduction of some remarkably detailed radiographs and several well-prepared drawings. The volume begins with a straight-forward short and well-illustrated presentation of the familiar pancreatic ductal embryology. This is followed by what is probably one of the best illustrated expositions available on the roentgenographic evaluation of the pancreas. The illustrations are beautifully clear and demonstrate a wide variety of pathology as seen by endoscopic retrograde pancreatography, computed tomography, and ultrasound. This is probably
THE PEOPLE'S PILL
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Use of Plastic Adhesive for Reinforcement of a Ruptured Intracranial Aneurysm
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Masculinization of the Fetus during Pregnancy Due to Inhalation of Diesel Exhaust
Authors: Nobue Watanabe, Masayuki Kurita
Journal: Environmental Health Perspectives (2001)

This study was conducted to determine the impact of diesel exhaust inhalation on the fetus. Seventy-two pregnant rats and 18 nonpregnant rats were divided into three groups: a group exposed to total diesel engine exhaust containing 5.63 mg/m(3) particulate matter, 4.10 ppm nitrogen dioxide, and 8.10 ppm nitrogen oxide; a group exposed to filtered exhaust without particulate matter; and a group exposed to clean air. The exposure period was from day 7 until day 20 of pregnancy. In addition, 15 pregnant rats were treated with aromatase inhibitors or testosterone to clarify the process by which diesel exhaust exerts its toxicity. The anogenital distance was significantly longer in male and female fetuses from both exhaust-exposed groups than in those of the control. Differentiation of the testis, ovary, and thymus was delayed and disturbed. Maternal testosterone and progesterone levels, which increased due to pregnancy whether or not the rats were exposed, were significantly higher and lower, respectively, in the pregnant rats exposed to total exhaust and filtered exhaust. The serum adrenocorticotropic hormone (ACTH) level and urinary excretion of 17-hydroxycorticosteroids (OHCS) did not differ among the pregnant groups. These results indicate that elevated testosterone did not result from elevated maternal adrenal function. The feto-placental-ovarian unit and inhibition of aromatase activity and synthesis caused by diesel exhaust inhalation might have played an essential role in the accumulation of testosterone. Since both exhaust-exposed groups showed almost the same reactions toward the inhalation, the gaseous phase must have included the relevant toxicants.
THE UNITED STATES PUBLIC HEALTH AND MARINE-HOSPITAL SERVICE.PART I.—A HISTORICAL SKETCH.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Announcement
Journal: Psychotherapy and Psychosomatics (1983)

We have the pleasure of announcing that the next World Congress of Psychosomatic Medicine is to be held in Hamburg in the Federal Republic of Germany.The Congress will take place immediately after the World Congress of Psychiatry in Vienna.The Congress language will be English.The scientific program will include 5 plenary sessions, 50 symposia, plus sessions for free communications and a general poster session, dealing with the following topics: Pre vention of psychosomatic disorders: Psychotherapy;
Resistant Anaemia
Authors: A. H. Douthwaite, R. L. Waterfield
Journal: BMJ (1946)

procedure this operation has its justifications, but it is question- able if it will appreciably increase life expectancy.It is yet too early to form a final judgment.Further reports on the progress of these children will be awaited with interest.Summary Surgery can obliterate the patent ductus arteriosus and eradicate the congenital stenosis of the distal aortic arch known as coarctation of the aorta.The clinical diagnosis of these defects is discussed.The diagnosis of coarctation of the aorta is missed repeatedly in childhood by a failure to palpate the groins as a routine procedure.Feeble or absent femoral pulses make a characteristic finding.An account is given of four children in whom this defect was observed.Diagnosis of these congenital flaws within the first ten years of life is important if full advantage is to be taken of current surgical procedures designed for their correction.
Deaths due to sexually transmitted diseases. The forgotten component of reproductive mortality
Authors: D. A. Grimes
Journal: JAMA (1986)

Reproductive mortality has three principal components: deaths related to pregnancy, contraception, and sexually transmitted diseases (STDs). The last component is usually overlooked. In 1955, deaths due to STDs constituted a minimum of 32% of all reproductive mortality in the United States; in 1965 and 1975, the percentages were 32% and 20%, respectively. Pelvic inflammatory disease and syphilis account for most deaths due to STDs. In 1979, the mortality rate due to pelvic inflammatory disease was 0.29 deaths per 100,000 women aged 15 to 44 years; the corresponding figure for syphilis was 0.17. If cervical cancer is viewed as an STD, then deaths due to this cause alone (approximately 6,800 per year) would far outnumber deaths due to all other reproductive causes combined. Surveillance of reproductive mortality in the United States should be expanded to encompass deaths due to STDs. (<i>JAMA</i>1986;255:1727-1729)
ABSTRACTS
Journal: Journal of Clinical Investigation (1965)

City, Iowa.Forelegs of anesthetized dogs were perfused with blood at constant rates of flow.Pressures were measured in the brachial artery and vein, in a small artery and vein in the paw, in a small artery and vein in muscle, and at various points along the course of the ulnar and metacarpal arteries.Venous outflow through the cephalic vein, which drains paw, and the brachial vein, which drains muscle, were measured simultaneously.Increases in vascular resistance during sympathetic stimulation were most pronounced in large artery segments.This constriction was predominant in vessels greater than 0.5 mm o.d.immediately upstream from the metacarpal arteries; it caused significant diversion of blood flow away from the paw.Significant constriction occurred also in arteries of similar size in muscle.Sodium concentration averaged 34.3 mEq per 100 g of dried tissue at the level of the trifurcation of the ulnar artery immediately up- stream from the metacarpal arteries, and 38.1 mEq in arteries of similar size in muscle.These concentrations were at least 20% greater than those in arterial seg- ments both downstream (metacarpal arteries) and upstream (ulnar and brachial arteries) from the trifurca- tion (p < 0.05).Higher sodium content could not be attributed to a larger inulin space; this suggests an in- crease in the amount of bound sodium.Potassium con- centration averaged 8.1 mEq in the brachial artery.This amount was 40% lower than that found in arterial seg- ments downstream in the foreleg (p <0.01).Adminis- tration of ethacrynic acid (a potent natriuretic), 1 mg per kg for 1 week, failed to alter either sodium content or responsiveness of arterial segments.We conclude
BAD SPELLING BY PHYSICIANS.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Screening for prostate cancer. A decision analytic view
Authors: M. D. Krahn
Journal: JAMA (1994)

<h3>Objective.</h3> —To determine the clinical and economic effects of screening for prostate cancer with prostate-specific antigen (PSA), transrectal ultrasound (TRUS), and digital rectal examination (DRE). <h3>Design.</h3> —Decision analytic cost-utility analysis comparing four screening strategies with a strategy of not screening. We assumed that the cancer detection rate and stage distribution were predicted by each combination of tests and that localized cancer was treated with radical prostatectomy. For each strategy, we calculated life expectancy, quality-adjusted life expectancy (QALE), and cost-utility ratios for unselected and high-prevalence populations. <h3>Data.</h3> —Probabilities and rates for clinical events were gathered from published data. We assessed utilities by the time—trade-off method using urologists, radiation oncologists, and internists as subjects. The Clinical Cost Manager at the New England Medical Center provided cost data. <h3>Results.</h3> —In unselected men between the ages of 50 and 70 years, screening with PSA or TRUS prolonged unadjusted life expectancy but diminished QALE. Screening with DRE alone yielded no reduction in mortality at any age. All programs increased costs. Results were sensitive only to assumptions about the efficacy of treatment. In high-prevalence populations, screening produced a similar pattern: gains in unadjusted life expectancy, losses in QALE, and increased costs. <h3>Conclusions.</h3> —Our analysis does not support using PSA, TRUS, or DRE to screen asymptomatic men for prostatic cancer. Screening may result in poorer health outcomes and will increase costs dramatically. Assessment of comorbidity, risk attitude, and valuation of sexual function may identify individuals who will benefit from screening, but selecting high-prevalence populations will not improve the benefit of screening. (<i>JAMA</i>. 1994;272:773-780)
SCIENCE AND REST.
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Common gamma chain (¿c) cytokines differentially potentiate TNFR family signaling in antigen-activated CD8 + T cells
Authors: Michael J McNamara, Melissa J Kasiewicz, Stefanie N Linch, Christopher Dubay, William L Redmond
Journal: Journal for ImmunoTherapy of Cancer (2014)

Several members of the common gamma chain (gc) cytokine family are already approved (IL-2) or actively being developed as vaccine adjuvants and cancer immunotherapies. Studies have indicated that co-administration of gc cytokines may enhance the efficacy of immunotherapies that function via direct activation of co-stimulatory T cell receptors. To define the specific influence of gc cytokines on the co-stimulatory capacity of CD8+ T cells and identify combinations with synergistic potential, we investigated the direct impact of gc cytokines on the differentiation and transcriptional profile of recently antigen-primed CD8+ T cells. Naïve CD8+ T cells were activated with peptide-pulsed APCs. After 48 hours, CD8+ T cells were harvested and re-cultured in media supplemented with IL-2, IL-4, IL-7, IL-15 or IL-21. After 24 hours, cells were analyzed by cytokine bead array, flow cytometry, and mRNA micro-array. Gene networks responsible for specific CD8+ T cell functions were constructed through literature-meta review and publicly available annotation databases. Gene expression data from the experimental groups was imported into this network to visualize the impact of each gc cytokine on the functional polarization of recently-activated CD8+ T cells. Among the gc cytokines, IL-2 induced the greatest increase in the expression of co-stimulatory receptors in recently-activated CD8+ T cells. IL-2 increased significantly expression of 4-1BB, GITR, ICOS and OX40, at both the transcriptional and protein level. IL-2 also drove the greatest increase in cellular proliferation and the most robust shift towards a pro-survival phenotype, compared with the other gc cytokines. Both IL-4 and IL-21 enhanced expression of cytotoxic effector proteins, but drove distinct phenotypic polarizations, Th2/Tc2 and NK-like, respectively. Overall, these observations suggest that among gc cytokines, IL-2 may be uniquely capable of synergizing with therapeutic strategies that combine immunization with agonists of co-stimulatory T cell receptors. Previous studies have shown that the timing of IL-2 treatment relative to immunization plays a key role in defining the CD8+ T cell response, and the findings from this study indicate that administration of exogenous IL-2 shortly after the initial antigen-priming event has concluded may augment the receptivity of these cells to subsequent TNFR co-stimulation.
THERMIC FEVER.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Note from the editors: World Tuberculosis Day 2018 and Special issue–Screening and prevention of infectious diseases in newly arrived migrants in Europe
Journal: Eurosurveillance (2018)

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A RAPIDLY ELIMINATED DIGITALIS BODY
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Contents
Authors: Gui-Shuang Ying, Maureen Maguire, Lynn Cyert, Elise Ciner, Graham Quinn, Marjean Kulp, Deborah Orel-Bixler, Bruce Moore, Mette Bertelsen, Allan Linneberg, Nynne Christoffersen, Henrik Vorum, Timothy Jackson, Paul Donachie, Ahmed Sallam, John Sparrow, Kurt Cornish, Noemi Lois, Neil Scott, Jennifer Burr, Jonathan Cook, Charles Boachie, Ramin Tadayoni, La Cour, Ulrik Christensen, Alvin Kwok, Ebenezer Daniel, Cynthia Toth, Juan Grunwald, Glenn Jaffe, Daniel Martin, Stuart Fine, Jiayan Huang, Stephanie Hagstrom, Katrina Winter, Jin Jie, Gabriëlle Buitendijk, Elena Rochtchina, Kristine Lee, Barbara Klein, Cornelia Van Duijn, Victoria Flood, Stacy Meuer, John Attia, Chelsea Myers, Elizabeth Holliday, Ava Tan, Wayne Smith, Sudha Iyengar, T De Jong, Albert Hofman, Johannes Vingerling, Paul Mitchell, Ronald Klein, Caroline Klaver, Mark Gillies, Richard Walton, Jennifer Arnold, Ian Mcallister, Judy Simpson, Alex Hunyor, Robyn Guymer, Rohan Essex, Nigel Morlet, Daniel Barthelmes
Journal: Ophthalmology (2014)
REWARDS OF EXPERIMENTAL MEDICINE
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal