tbuckley/cabot-search huggingface dataset:
Terminal Dehydration as an Alternative to Physician-Assisted Suicide
Authors: Timothy E. Quill
Journal: Annals of Internal Medicine (1998)

Letters15 December 1998Terminal Dehydration as an Alternative to Physician-Assisted SuicideTimothy E. Quill, MD, Susan D. Block, MD, and J. Andrew Billings, MDTimothy E. Quill, MDThe Genesee Hospital; Rochester, NY 14607Harvard Medical School; Boston, MA 02215Massachusetts General Hospital; Boston, MA 02114Search for more papers by this author, Susan D. Block, MDThe Genesee Hospital; Rochester, NY 14607Harvard Medical School; Boston, MA 02215Massachusetts General Hospital; Boston, MA 02114Search for more papers by this author, and J. Andrew Billings, MDThe Genesee Hospital; Rochester, NY 14607Harvard Medical School; Boston, MA 02215Massachusetts General Hospital; Boston, MA 02114Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-129-12-199812150-00038 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSEAlthough language is often misused or politicized in policy debates about end-of-life care [1], terms such as terminal sedation and voluntarily stopping eating and drinking (VSED) should not be simply dismissed as surrogates for euthanasia or assisted suicide.As suggested by Dr. Seely, we should use accurate language to define such acts [2]. VSED is a more accurate term than terminal dehydration because it captures the willful nature of the act and clearly distinguishes it from the decision to withhold or withdraw artificial hydration for patients who cannot eat or drink because of their disease. Terminal sedation is ...References1. Brody H. Causing, intending and assisting death. J Clin Ethics. 1993; 4:112-7. Google Scholar2. Quill TE, Lo B, Brock D. Palliative options of last resort: a comparison of voluntarily stopping eating and drinking, terminal sedation, physician-assisted suicide and voluntary active euthanasia. JAMA. 1997; 278:2099-104. Google Scholar3. Quill TE, Dresser R, Brock DW. The rule of double effect: a critique of its role in end-of-life decision making. N Engl J Med. 1997; 337:1768-71. Google Scholar4. Billings JA. Dehydration. In: Berger A, Portenoy RK, Weissman DE, eds. Principles and Practice of Supportive Oncology. Philadelphia: Lippincott-Raven; 1998:589-601. Google Scholar5. Billings JA, Block SD. Slow euthanasia. J Palliative Care. 1996; 12:21-30. Google Scholar Author, Article, and Disclosure InformationAffiliations: The Genesee Hospital; Rochester, NY 14607Harvard Medical School; Boston, MA 02215Massachusetts General Hospital; Boston, MA 02114 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 December 1998Volume 129, Issue 12Page: 1082KeywordsEatingEuthanasiaFirearm injuriesHealth carePalliative careSedationSuicide Issue Published: 15 December 1998 CopyrightCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
32P-postlabeling assay for carcinogen-DNA adducts: nuclease P1-mediated enhancement of its sensitivity and applications.
Authors: M V Reddy, K Randerath
Journal: Environmental Health Perspectives (1987)

Exceedingly sensitive assays are required for the detection of DNA adducts formed in humans exposed to low levels of environmental genotoxicants and therapeutic drugs. A 32P-postlabeling procedure for detection and quantitation of aromatic carcinogen-DNA lesions with a sensitivity limit of 1 adduct in 10(7) to 10(8) nucleotides has been described previously. In the standard procedure, DNA is enzymatically digested to 3'-phosphorylated normal and adducted mononucleotides, which are 32P-labeled at 5'-hydroxyl groups by T4 polynucleotide kinase-catalyzed [32P]phosphate transfer from [gamma-32P]ATP. 32P-labeled derivatives are resolved by TLC, detected by autoradiography, and quantitated by counting. This assay has been recently utilized for the determination and partial characterization of DNA adducts formed in somatic and reproductive tissues of rats given the clinically used anticancer drug, mitomycin C. The drug exhibits similar levels of covalent binding to DNA in most tissues. Further studies have revealed that adducted nucleotides are primarily guanine derivatives that are resistant to 3'-dephosphorylation by Penicillium citrinum nuclease P1. The latter observation has been utilized to enhance the 32P-assay's sensitivity to 1 adduct in 10(10) nucleotides for a 10-micrograms DNA sample by postincubation of DNA digests with nuclease P1 before 32P-labeling. The enzyme dephosphorylates the normal nucleotides but not most aromatic and bulky nonaromatic adducts, so that only the latter serve as substrates for the kinase-catalyzed labeling reaction. The new assay has also shown utility in the analysis of very low levels of age- and tissue-related DNA modifications, which might arise from dietary or endogenous compounds, in untreated rats and in humans.
" Parasite and Host."
Authors: None M.
Journal: JAMA (1896)

Philadelphia, Pa., Nov. 18, 1896. <h3>To the Editor:</h3> —In reference to the paragraph in your editorial of November 14 "Parasite and Host," in which you allude to the abuses of the review columns of lay-published medical journals, an instance has just come to my knowledge too opposite to be omitted: The publishing house of one of our most self-righteous and " honorable" journals recently got the author of a book to review the later work of a rival author upon the same subject. Instead of the review appearing after the usual and necessary lapse of time required to weigh and value the work judicially, it came out in the next issue of the journal after the book had dropped from the press, and was made up of snarling, fault-finding bumptiousness, derision and superficial disingenuousness. The rival publisher and rival author joined hands and danced in murderous joy over their powerless foes—but
Corrections: Reinstated p53 response and high anti-T-cell leukemia activity by the novel alkylating deacetylase inhibitor tinostamustine
Authors: S. Pützer, L. Varghese, J. von Jan, T. Braun, A. K. Giri, P. Mayer, N. Riet, S. Timonen, S. Oberbeck, H. Kuusanmäki, S. Mustjoki, M.-H. Stern, T. Aittokallio, S. Newrzela, A. Schrader, M. Herling
Journal: Leukemia (2020)
SCDT-42. ENHANCED IN VIVO EFFICACY AND SAFETY OF COMBINATION TEMOZOLOMIDE AND BROMODOMAIN INHIBITOR THERAPY FOR GLIOMAS USING A TARGETED DUAL DRUG-LOADING STEALTH LIPOSOMAL CARRIER
Authors: Fred C Lam, Stephen W Morton, Jeffrey Wyckoff, Amanda Maffa, Elena Balkanska-Sinclair, Scott R Floyd, Michael B Yaffe, Paula T Hammond
Journal: Neuro-Oncology (2017)

Effective treatment for gliomablastoma (GBM) is limited by the presence of the blood-brain barrier (BBB) and rapid resistance to single agent therapies. To address these issues, we developed a transferrin functionalized nanoparticle (Tf-NP) that can deliver dual combination therapies. Using intravital imaging, we show the ability of Tf-NPs to traverse the intact BBB in mice as well as achieve direct tumor binding in two intracranial orthotopic models of GBM. Treatment of tumor-bearing mice with Tf-NPs loaded with temozolomide and the bromodomain inhibitor JQ1 led to increased DNA damage and apoptosis in tumor tissue that correlated with decreased tumor burden and significant survival benefits compared to equivalent free-drug dosing. Immunocompetent mice treated with Tf-NP-loaded drugs also showed protection from the effects of systemic drug toxicity, demonstrating the preclinical potential of this platform to deliver novel combination therapies for gliomas and other central nervous system tumors.
2008 Sol Sherry Distinguished Lecture in Thrombosis—Platelet Adhesion in Acute Arterial Thrombosis
Authors: Zaverio M. Ruggeri
Journal: Circulation (2008)

Platelet adhesion is an essential function in response to vascular injury, through which single platelets bind to specific membrane receptors onto cellular and extracellular matrix constituents of the vessel wall and tissues initiating thrombus formation that arrests hemorrhage and permits wound healing. Pathological conditions that cause vascular alterations and blood flow disturbances may turn this defense process into a disease mechanism resulting in arterial occlusion, mostly in atherosclerotic vessels of the heart and brain. Besides their relevant role in hemostasis and thrombosis, platelet adhesive properties are central to a variety of pathophysiological processes that extend from inflammation to immune-mediated host defense and pathogenic mechanisms as well as cancer metastasis. All these activities depend on the ability of platelets to circulate in blood as sentinels of vascular integrity, adhere where alterations are detected, and signal the abnormality to other platelets and blood cells. In this respect, therefore, platelet adhesion to vascular wall structures, to one another (aggregation), or to other blood cells represents different aspects of the same fundamental biological process. Novel concepts and tools are being developed to advance our knowledge of the mechanisms through which platelets respond to vascular injury. Of particular interest are specific microparticles endowed with selective targeting properties conferred by recombinant adhesive domains that may be used for targeting areas of the vasculature with thrombogenic potential and for diagnostic purposes. Particles with such specific adhesive properties may also be used for the local delivery of anti-thrombotic drugs.
INEBRIETY AMONG WOMEN IN THIS COUNTRY.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prognostic Irrelevance of Ring Sideroblast Percentage in World Health Organization Defined Myelodysplastic Syndromes without Excess Blasts,
Authors: Mrinal M. Patnaik, Curtis A Hanson, Nanna Sulai, Janice M Hodnefield, Ryan A Knudson, Rhett P Ketterling, Terra L Lasho, Ayalew Tefferi
Journal: Blood (2011)
The vigorous diagnostic approach to upper-gastrointestinal tract hemorrhage. A 23-year prospective study of 1,4000 patients
Authors: E. D. Palmer
Journal: JAMA (1969)

Diagnostic management of 1,400 patients with severe, active upper-gastrointestinal tract hemorrhage by immediate esophagogastroscopy and contrast roentgenography provided confident identification of the bleeding lesion in 93%. Preexamination ice-water lavage of the stomach by Ewald tube and syringe proved remarkably effective for control of active hemorrhage. Seven hundred and eleven potentially bleeding lesions that were not playing a part in the hemorrhage were discovered. Duodenal ulcer was responsible for only one fourth of the hemorrhages. Erosive esophagitis and erosive gastritis were the cause of approximately 7% and 12% of the hemorrages, respectively, with death rates of 3% and 9%, respectively. There was one endoscopic injury (perforation through Zenker's diverticulum). Emergency surgical treatment was necessary to control hemorrhage in 16.1% of the 1,400 patients. The overall mortality was 7.9%.
Pediatrics
Authors: J. A. McMillan
Journal: JAMA (1991)

As is so often the case in pediatrics, prevention, especially the use of vaccines, proved to be one of the major areas of attention during the past year. Other major developments included reports of a role for vitamin A for the possible prevention of millions of childhood deaths worldwide and the demonstration of a method for producing a more optimistic developmental outcome for the low-birth-weight infant. In October 1990 a diphtheria protein—conjugated<i>Haemophilus influenzae</i>type b vaccine (HibTITER, Praxis Biologics Inc, Rochester, NY) was licensed for use in infants beginning at 2 months of age.<sup>1</sup><i>Haemophilus influenzae</i>type b is the most frequent cause of invasive bacterial infection among children between the ages of 1 month and 3 years. Immunologic immaturity of infants and young children has made vaccine prevention for this most susceptible age group impossible in the past. Capsular polysaccharide vaccine (PRP) was licensed in the United
Erratum
Journal: BMJ (1926)

Hankow is a cystoscopist he will Iibid that phenol red works cluite vell if the bladder is distended with a sterile solution of sodium bicarbonate, a drach-m to the pinit.The most satis- factory dye, however, is indigo carmine 0.4 per cent., 10 c.cm. being injected intravenously.This is obtainable in sterile ampoules.TREATMENT OF DvsCHEZIA.DR. R. MACDONALD LADEIL (Birminigham) writes in reply to "Hl.M1.":It seems possible that the case might be treated successfully by meains of psychotherapy.The desire for local treatmetnt may be a suibstitution, a gratification which analysis woul(l nmake clear anid remove.If psycho-anal)sis is not consi(lered desirable, it is likely that hypnotic suggestion alone would relieve the symptoms. INCOME TAX.Replacemiienit of Car."A.H. L. T." bouglht a 10/15 " F " car in 1922 for £575 and sold it in 1925 for £220, buying a similar saloon car for £378; the latter car was not a success and in 1926 he sold it for £325, buyitng a 14/40 "8" saloon for £805.To wbat allowances is be entitled?* * * As a professional expense of the year 1925 on the grounds of
HPV Vaccine Works against Nine Viral Types
Journal: Cancer Discovery (2013)

In a phase III study, Merck's new V503 human papillomavirus (HPV) vaccine prevented 97% of high-grade, precancerous vaginal, vulvar, and cervical disease caused by HPV types 31, 33, 45, 52, and 58. The new vaccine also generated immune responses to HPV types 6, 11, 16, and 18 that were as good as or better than those generated by the company's Gardasil vaccine.
Alcoholism Research
Authors: R. J. BING
Journal: Annals of Internal Medicine (1977)

Comments and Correction1 April 1977Alcoholism ResearchR. J. BING, M.D.R. J. BING, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-86-4-504_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I have read the editorial by Enoch Gordis, "What Is Alcoholism Research?" (Ann Intern Med 85:821-823, 1976), with great interest.Its main thesis stands in the last sentence, where Dr. Gordis writes that the search for potent therapy will "succeed only if alcoholism is the target, not its familiar consequences." In preceding paragraphs, Dr. Gordis has defined the direction that research on alcoholism should take as concerning itself with loss of control (inability to regulate alcohol intake), craving, tolerance, and physical dependence. He believes that the primary goal of alcoholism research is to understand these four phenomena....References1. : Criteria for the diagnosis of alcoholism. Ann Intern Med 77:249-258, 1972 LinkGoogle Scholar2. OSLER W: Principles and Practice of Medicine. New York, Appleton, 1892, pp. 1004-1005 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: R. J. BING, M.D.Affiliations: Huntington Memorial Hospital Pasadena, CA 91105 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1977Volume 86, Issue 4Page: 504-504KeywordsAlcoholismAlcohols ePublished: 1 December 2008 Issue Published: 1 April 1977 PDF downloadLoading ...
News from the American Heart Association
Authors: S Sarnoff, J Gilmore, N Skinner, A Wallace, J Mitchell
Journal: Circulation Research (1963)

A variety of factors have been considered to be of importance in influencing the oxygen consumption of the heart.Among these have been the amount of work done by the heart, 1 ' 2 the end diastolic volume or fiber length, 3 " 5 the heart rate, 6 " 10 the developed myocardial tension, 11 and the heart rate times the mean arterial pressure. 12More recently, it has been suggested that coronary blood flow may influence myocardial oxygen consumption independently of changes in the activity of the heart. 13" 17 The objective of the investigation described below was to ascertain whether or not this occurs in the isolated, metabolically supported heart preparation and, if so, under which experimental circumstances. MethodsExperiments were performed on mongrel dogs of both sexes ranging in weight from 20.0 to 27.0 kg.The animals were anesthetized with a warmed mixture of ehloralose (60 mg/kg) and urethane (600 nig/kg) given intravenously.The experimental preparation employed was a modification of the isolated supported heart. 18This is shown in figure 1.A large-bore eannula was inserted into the left atrium through the appendage and then connected to a blood reservoir (RES) by way of an electrically operated inflow resistance (IR).Atrial inflow was continuously recorded using a Potter eleetroturbinometer (PET). 19The lower thoracic aorta was ligated and a eannula inserted proxirnally.Outflow from the aorta was led to the blood reservoir (RES) through a second, electrically operated, outflow resistance (OR).A eannula previously placed in the left main pulmonary artery was connected through a recording rotameter (TR) to a reservoir (TCR) supplying blood to the support dog's (SD) jugular veins.Previously placed ligatures around the subclavian and brachiocephalic arteries, superior and inferior venae cavae, the azygos vein, the hilum of the
Chronic gastric ulcer on the posterior wall
Authors: E. D. Palmer
Journal: JAMA (1974)

CHRONIC ulcers that lie on the posterior gastric wall demonstrate some unique clinical and pathologic features that can be attributed to their anatomic location. This does not apply to craters that reach the lesser curve, although strangely, it includes those that extend to the greater curve. The clinician has observed that the chronic posterior wall ulcer is encountered mainly in older patients. Summarizing some large series recorded in the literature, one finds that about 65% of all chronic posterior wall lesions of the pars media are first recognized after age 50, as compared with only 35% of chronic anterior wall pars media ulcers. The figures for craters that lie within the antrum and within the fundus are difficult to interpret because of varying definitions of these anatomic regions. French and German radiologists and surgeons have emphasized on many occasions that more than the expected proportion of women is encountered among
Section Registration
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CHAIRMAN'S ADDRESS.
Authors: AUGUSTUS P. CLARKE
Journal: JAMA (1898)

The physiology of the various structures of the organism and the choice of the pabulum best adapted to their conservation are subjects that should command our most careful consideration. Formerly when disease was regarded as an entity and a visitation of an offended deity, only little, of course, could be expected to be achieved by dietetic measures. Success that could be obtained, however, by treatment of disease through a change or a restricting of the diet is by no means a modern discovery; the medieval and the ancient writings on medicine reveal many references to the subject. Thus the works of Hippocrates, the "Father of Medicine," show that he was not unacquainted with the evil effects arising from an unwise selection of articles of diet; he speaks of the enervation that results to the constitution from abstinence of food. Knowledge of the fundamental principles of dietetics is essential for the
Panniculitis, vasculitis, and a positive lupus erythematosus cell test
Authors: K. L. Macoul
Journal: JAMA (1967)

RELAPSING, nodular, nonsuppurative panniculitis is rare and of unknown etiology. It is characterized by fever (87% of cases)<sup>1</sup>and spontaneous appearance of subcutaneous nodules on the extremities or trunk. The following have been suggested as possible causes of subcutaneous, nodular panniculitis<sup>2</sup>: halogen compounds, infections (especially tuberculosis), trauma, faulty fat metabolism, drug ingestion, and antigen-antibody reactions.<sup>3</sup>Cases of migratory, nonsuppurative panniculitis have also been reported in association with rheumatoid arthritis,<sup>4,5</sup>erythema nodosum,<sup>5</sup>dermatomyositis,<sup>5</sup>and sarcoid.<sup>6</sup>Thus it has been suggested that migratory nodular panniculitis is related to collagen disorders. The following report is an interesting case of afebrile, nodular, nonsuppurative panniculitis in a patient with positive lupus erythematosus (LE) cell tests, ulcerative colitis, erythema nodosum, and small-vessel vasculitis. <h3>Report of a Case</h3> A 40-year-old widow (197854) entered the Mount Auburn Hospital for the ninth time on July 23, 1965 complaining of lumps on all
Peptide portions may hold key to amplifying bone against porosis
Authors: P. Cotton
Journal: JAMA (1990)

PIECES OF PEPTIDES that are encoded in the calcitonin gene may explain enigmas in treatment of bone disease. Amplification of bone formation by two peptides with similar amino acid sequences was reported at the Third International Conference on the Fundamentals of Bone Growth at the University of California, Los Angeles (UCLA), schools of medicine and dentistry. One treatment enigma is that calcitonin regulates normal bone resorption but does not work as well when administered for the treatment of osteoporosis, says Guy Howard, MD, Veterans Administration Medical Center, Miami, Fla. While hormone therapy does work, it has wide-ranging effects like the potential for an increased risk of breast cancer. <i>N</i>-procalcitonin (<i>N</i>-proCT), which is produced by the amino acids that precede those encoded for calcitonin, "may speak to" that enigma, Howard said in presenting the first in vivo results on the new peptide. In vitro, it stimulates proliferation of bone-forming