tbuckley/cabot-search huggingface dataset:
WHAT LEGALLY CONSTITUTES THE PRACTICE OF MEDICINE.
Journal: JAMA (1907)

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THE AURICULAR HEART SOUNDS
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nickel Sensitivity
Authors: Jonathan Cohen
Journal: JAMA (1972)

<h3>To the Editor.—</h3> The case reported by Drs. Barranco and Soloman (220:1244, 1972) was interesting in view of the increasing use internally of nickelcontaining steel, not only for orthopedic purposes, but also in sutures. Physicians should encounter more cases of dermatitis attributable to implanted metals, and I myself know of a case presumed to be such, although the metal has not yet been removed. Barranco and Soloman, in their report, however, not only have included errors in their data on the composition of the steel that are obvious to any metallurgist, but also have ignored some simple but important data concerning the screws, which should have been recorded. From the percentages of elements they report, ignoring the error in content of magnesium (certainly not 12%), one cannot be sure if the steel in either screw conformed to the specifications for type 316 or 317, which now are generally well followed
Index to Advertisers
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Delayed idiosyncratic psychosis with diphenylhydantoin
Authors: C. E. McDanal
Journal: JAMA (1975)

A PATIENT had a delayed idiosyncratic psychosis to diphenylhydantoin sodium. We have not found another case in the medical literature that described this type of reaction to diphenylhydantoin with supportive blood level data. Stevens<sup>1</sup>mentioned four reports of epileptic patients with bizarre, psychotic signs and symptoms who were treated with changes in anticonvulsant medication, neuroleptic drugs, and environment. Unfortunately, no anticonvulsant blood levels were mentioned. The side effects of diphenylhydantoin fall into two categories: dose dependency or individual hypersensitivity or idiosyncratic response. Sparberg<sup>2</sup>described the medical complications of diphenylhydantoin therapy and concluded that they were diagnostically confusing. <h3>Report of a Case</h3> A 30-year-old mother of three children had had seizures since she was 12 years old but none in the past four years. She received anticonvulsant medications, mephobarbital, 32 mg four times daily, and diphenylhydantoin sodium, 100 mg four times daily. The patient faithfully took the medication; she
The MRI
Authors: Judith Skillman
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lectures on the Diagnosis and Treatment of Hip-Disease in Children
Authors: H. Marsh
Journal: BMJ (1877)

GENTLEMEN,-Formerly, hip-disease was so imperfectly understood, that it commonly drifted on into the appearance of an intractable disorder, for which there was very little to be done.But in the last twenty or twenty-five years it has been carefully studied both in this country and in America.*It can now be detected while it is still incipient, and means have been introduced by which its early forms
Abstract 1573: Phosphorylation of Cardiac Troponin I by Mammalian Sterile20-like Kinase Mst1
Authors: Bei You, Guijun Yan, Zhiling Zhang, Jian-Ping Jin, Jianxin Sun
Journal: Circulation (2008)

Mammalian sterile 20-like kinase 1 (Mst1) is a ubiquitously expressed serine/threonine kinase and its activation in the heart causes cardiomyocyte apoptosis and dilated cardiomyopathy. Its myocardial substrates, however, remain unknown. In a yeast two-hybrid screen of human heart cDNA library with a dominant negative Mst1 (K59R) as bait, cardiac troponin I (cTnI) was identified as an Mst1-interacting protein. The interaction of cTnI with Mst1 was confirmed by co-immunoprecipitation in both co-transfected HEK293 cells and native cardiac myocytes, in which cTnI interacted with full length Mst1, but not with its N-terminal kinase fragment. In vitro phosphorylation assays demonstrated that cTnI is a sensitive substrate for Mst1 in its free form or in reconstituted troponin complex. In contrast, cardiac TnT was phosphorylated by Mst1 only when incorporated in the troponin complex. Mass spectrometric analysis indicated that Mst1 phosphorylates cTnI at Thr 31 , Thr 51 , Thr 129 , and Thr 143 . Substitution of Thr 31 with Ala substantially reduced Mst1-mediated cTnI phosphorylation by approximately 90%, while replacement of either Thr 51 orThr 129 , or Thr 143 with Ala reduced Mst1-catalyzed cTnI phosphorylation by approximately 60%, suggesting that Thr 31 is a preferential phosphorylation site for Mst1. Protein epitope analysis and binding assays showed that Mst1 mediated phosphorylation modulates the molecular conformation of cTnI and its binding affinity to TnT and TnC, thus indicating functional significances. Our results suggest that Mst1 is a novel mediator of cTnI and/or cTnT phosphorylation in the heart and may contribute to the modulation of myofilament function under a variety of physiological and pathophysiological conditions. This research has received full or partial funding support from the American Heart Association, AHA National Center.
Hormonal impact of salvage chemotherapy with carboplatin plus weekly docetaxel in patients with castration- and docetaxel-resistant prostate cancer (DRPC).
Authors: Christoph W. Reuter, Michael A. Morgan, Martin Fenner, Viktor Grünwald, Arnold Ganser
Journal: Journal of Clinical Oncology (2012)

74 Background: Recent data suggest that carboplatin may be effective in combination with docetaxel in DRPC. Platinum(II)-complexes have been shown to interfere with testosterone biosynthesis by inhibiting the cholesterol side chain cleavage enzyme (CYP11A1), 3b-hydroxysteroid dehydrogenase (HSD3B1,2) and 17a hydroxylase/C17,20-lyase (CYP17A1). Methods: Docetaxel failure/resistance was defined according to the Prostate Cancer Working Group (PCWG2 2007) criteria. Since February 2005, 68 consecutive DRPC pts were treated with at least two cycles of carboplatin AUC5 iv for 30 min on day 1 every 4 weeks (q4w), docetaxel at a dose of 35 mg/m2 iv for one hour on days 1, 8, (15) plus prednisone 2x5mg/day orally after receiving informed consent until disease progression or occurrence of intolerable adverse effects. Efficacy measures were done following PCWG2 recommendations. Free testosterone levels were measured before (n=42) and during DC treatment (n=36). Results: Response of prostate-specific antigen (PSAR; ≥50% PSA) was observed in 32/68 (47.1%) patients. At the time of the current analysis the median follow-up time was 13.6 months and 43/68 patients had died. Median progression-free survival (PFS) for all patients was 7.5 months (CI 95% 5.4, 9.5) and median overall survival (OS) was 18.6 months (CI 95% 12.3, 24.9). In PSAR, PFS was 15.7 versus 4.8 months in PSANR (p&lt;0.001; hazard ratio HR 0.19, CI 0.09, 0.39) and OS was 25.6 versus 8.1 months (p&lt;0.001; HR 0.21 CI 0.10, 0.42). This regimen was reasonably well tolerated, with leukopenia/neutropenia as the most common reversible grade 3/4 toxicity (39.7/33.8%). Median free testosterone levels were 0.935 pg/ml before and 0.185 pg/ml during DC treatment (nadir; p&lt;0.001). While free testosterone levels before DC treatment were associated with lower PSAR (HR 6.32 CI 1.60, 25,0; p=0.009), free testosterone nadir levels &lt;0.18 pg/ml during DC treatment were associated with higher PFS (HR 0.126 CI 0.04, 0.46, p=0.002) and OS (HR 0.07 CI 0.008, 0.53; p=0.01). Conclusions: These data suggest that DC may be an important second-line treatment option for DRPC patients by inhibiting the testosterone biosynthesis.
JAUNDICE IN THE ARMED FORCES
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ULCERATIVE COLITIS
Authors: H. E. Bacon
Journal: JAMA (1960)

<h3>To the Editor:—</h3> It is a privilege to answer the comments of our honored colleague, Dr. Fradkin, who speaks with authority. It is unfortunate, however, that he has not felt inclined to keep abreast of the current results of therapy, both medical and surgical. We agree that the initial management of chronic ulcerative colitis should be medical. In fact, only 26.4% of 468 patients of the senior author (H. E. B.) were subjected to colectomy, whereas 73.6% were continued on medical management. This decision was made despite the fact that the majority had been previously considered as medical failures. We doubt that Dr. Fradkin, in his 30 years of experience, has devised a new approach to the medical treatment of chronic ulcerative colitis substantially different from that used in Philadelphia. The plan of treatment he has advocated is used more or less routinely, but we still meet with failures which
Amenorrhea associated with carotenemia
Authors: E. Kemmann
Journal: JAMA (1983)

Data are presented for ten women with anovulation, nine of them with amenorrhea, who have associated carotenemia. Classic explanations for carotenemia in amenorrheic patients have been weight loss or anorexia nervosa, yet carotenemia in our patients appeared to be diet induced. All patients consumed a pure or predominantly vegetarian diet; there was no intake of red meats. Clinical and laboratory data of the patients are presented. The amenorrhea of the patient is consistent with hypothalamic hypogonadotropic anovulation (HHA). It appeared that diet modification not only led to reduction in carotene levels, but also improved the menstrual status. The association of carotenemia and menstrual disorders is reviewed. The possibility that carotenemia is related to the development of HHA is discussed. (<i>JAMA</i>1983;249:926-929)
Correction
Journal: BMJ (1945)

BMITISH MEDICAL J OU RNS\I1The only way in which dry rot in a house may affect the health of the occupants is by the sudden collapse of floors or other struc- tural timber.The superstition probably arises from the fact that the damp conditions which favour growth of the fungi may, in themselves, affect health adversely.Demerara v. White Sugar Q.-How does sugar-cane or beet become the white product on ouir table?Are any vitamins or minerals lost in the process?Is demtterara sugar better than white sugar ?A.-The juice obtained from beet-root or cane is evaporated and sugar crystallizes out.This sugar is redissolved and purified by the precipitation of salts, such as calcium carbonate, in the solution, and by treatment with activated charcoal.Vitamins and minerals of the cane or root are lost in the process.In the case of beet- root the chief vitamin lost is ascorbic acid.Demerara sugar contains small amounts of nitrogenous impurity, calcium, and iron, which are almost completely absent from white sugar.If our present ration of sugar were taken as demerara sugar it would increase the day's calcium and iron by 17 mg.and 0.3 mg.only. INCOME TAXExpenses of Employment W. T. inquires what expenses are allowable to a whole-time M.O.H. for income-tax purposes.*** The statutory rule is that expenses wholly, exclusively, and necessarily incurred in the performance of
Insulin Receptor Structure And Function In Normal And Pathological Conditions
Authors: A. Becker
Journal: Annual Review of Medicine (1990)

The insulin receptor is a large cell surface glycoprotein that concentrates insulin at the site of action and also initiates responses to insulin. The receptor is a disulfide-linked oligomer comprised of two α and two β subunits. Signal transduction through the insulin receptor appears to require the activation of an intrinsic tyrosine-specific protein kinase activity. A variety of disorders, both acquired and genetic, are associated with the development of insulin resistance and are frequently the result of cellular defects in insulin receptor structure, function, and action. The recent cloning of several mutant receptors from patients with genetic forms of extreme insulin resistance has increased our understanding of insulin resistance on the molecular level.
Annals of the Rheumatic Diseases, London
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Restructuring health care in the United States. A proposal for the 1990s
Authors: D. O. Nutter
Journal: JAMA (1991)

A PLAN for restructuring the US health care system to achieve universal access to medically necessary health care services has been developed by the Medical Schools Section of the American Medical Association (AMA). The plan is a pluralistic approach to comprehensive system reform that requires both individual and institutional responsibility for the achievement of quality health care. A set of broad strategies are proposed to reach the goal of universal access to care in the context of responsible containment of health care costs. The plan proposes to achieve universal access through reform of our existing system of health care as follows: by restructuring and reforming Medicaid and Medicare, by supporting universal provision of necessary health benefits through employers; and by the creation of regional insurance pools for those individuals who are not covered by government programs or through their workplace. The additional cost of these strategies for universal access would
A world-class program.
Journal: Environmental Health Perspectives (1999)

It is said that if you give a man a fish you feed him for a day, but if you teach him to fish you feed him for a lifetime. In the spirit of this adage, the International Training and Research in Environmental and Occupational Health (ITREOH) program trains health scientists, clinicians, epidemiologists, toxicologists, engineers, industrial hygienists, chemists, and allied health workers from developing countries in the skills they need to maintain environmental and occupational health in their countries both now and in the future.
Grundzüge der Kurortwissenschaft.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Chemistry and Physics; a Mauual for Students and Practitioners.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal