tbuckley/cabot-search huggingface dataset:
Abstract 4540: Discover cell signaling pathways using antibody arrays
Authors: Hao Tang, Jianmin Fang, Zhizhou Kuang, Ruo-Pan Huang
Journal: Cancer Research (2019)

Abstract Cell Signaling pathways are complex networks that are normally regulated and connected by multiple components. Analyzing signaling pathways is essential for understanding the molecular mechanism of human disease and drug development. However, it remains a great challenge to study pathways using traditional methods. Thus, a high-content and high-throughput method for simultaneous detection of multiple targets is necessary. Using a sandwich-based ELISA format, we have developed an antibody array technology which can simultaneously identify relative expression levels or phosphorylation levels of major signaling pathway proteins. This array-based system features a nitrocellulose membrane or glass slide solid support, each spotted with up to 71 different antibodies against a selected panel of classical signaling pathway proteins, including RTK, EGFR, MAPK, AKT, Apoptosis, TGFb, JAK/STAT, NFkB and Insulin Receptor pathways, spanning 182 total proteins. To test our system, we investigated the molecular mechanism of Camptothecin’s anti-cancer effect using several pathway arrays. Our array data suggest that Camptothecin-treatment induced DNA double-strand breaks in Jurkat cell activates the DNA damage pathways ATM and Chk2, and then further induces apoptosis through Caspase 3 and BAD. We also studied phorbol 12-myristate 13-acetate (PMA)’s effect on HeLa cells, and found that PMA induces the MAPK pathway through activation of Erk, MSK2, and RSK1. These array results are consistent with previous studies using traditional methods and were further confirmed by western blot analysis. Our studies demonstrate that pathway antibody arrays provide a rapid and efficient approach to study the mechanism of cell events, human diseases and drug effects. With this technology, researchers can quickly screen activation of multiple target proteins in one or multiple pathways in their experimental system. Citation Format: Hao Tang, Jianmin Fang, Zhizhou Kuang, Ruo-Pan Huang. Discover cell signaling pathways using antibody arrays [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4540.
Cancer and upper gastrointestinal tract hemorrhage. Benign causes of bleeding demonstrated by endoscopy
Authors: C. J. Lightdale
Journal: JAMA (1973)

The sources of upper gastrointestinal tract bleeding have been documented by endoscopy in 81 patients studied prospectively at Memorial Sloan-Kettering Cancer Center from 1969 to 1972. Hemorrhagic gastritis was most common cause of bleeding overall in 38 patients (47%), followed by chronic peptic ulcer disease in 18 patients (22%). Bleeding directly from tumor was present in only 10 patients (12%). Eighteen stomach tumors were seen endoscopically, but only ten were bleeding. Primary gastric carcinoma and secondary gastric lymphoma were likely to be the origin of hemorrhage, while other metastatic tumors were unlikely sources. Stress ulcers were important, accounting for more than half of the hemorrhagic gastritis in patients with malignant disease. The remaining cases of gastritis were associated with exogenous gastric irritants. These results indicate need for aggressive diagnostic approaches, with early endoscopy for patients with cancer who develop upper gastrointestinal tract bleeding.
Dog Bites Recognized as Public Health Problem
Authors: Rebecca Voelker
Journal: JAMA (1997)

IT'S TIME to take some teeth out of a largely unrecognized yet preventable public health problem. Every year in the United States, almost 2% of the population is bitten by a dog. The Centers for Disease Control and Prevention (CDC) in Atlanta, Ga, estimates that of those 4.5 million bites, almost 800 000 are serious enough to require medical attention. In extreme cases, about 18 people die from dog bites every year (<i>Pediatrics</i>. 1996;97:891-895 and<i>Injury Prev</i>. 1996;2:52-54). In many instances, the bite is the result of a pet owner not fully understanding the responsibility involved in owning a dog. Some dog owners disregard leash laws; others may not think twice before leaving infants or young children alone with a dog. Sometimes, parents allow their children to freely approach an unfamiliar dog on the street. "We have to educate dog owners on their responsibilities," says Westwood, Kan, consultant Wayne Hunthausen,
Biophysical changes reduce energetic demand in growth factor–deprived lymphocytes
Authors: Vivian C. Hecht, Lucas B. Sullivan, Robert J. Kimmerling, Dong-Hwee Kim, Aaron M. Hosios, Max A. Stockslager, Mark M. Stevens, Joon Ho Kang, Denis Wirtz, Matthew G. Vander Heiden, Scott R. Manalis
Journal: The Journal of Experimental Medicine (2016)
Keratinocytes resident in normal human skin constitutively express, at low levels, the intercellular adhesion molecule-1. An in situ immunoelectronmicroscopy study
Authors: A. LONATI, M.A. MOMMAAS, G. PASOLINI, A. LAVAZZA, B.J. VERMEER, G. PANFILIS
Journal: British Journal of Dermatology (1996)
Organochlorines in Breast Milk from Two Cities in Ukraine
Authors: Beth C. Gladen, Susan C. Monaghan, Elena M. Lukyanova, Olesya P. Hulchiy, Zoreslava A. Shkyryak-Nyzhnyk, Jose L. Sericano, Ruth E. Little
Journal: Environmental Health Perspectives (1999)

Reports of environmental problems in the former Soviet Union, including excess use of pesticides, have led to concerns about high levels of contamination in humans, but little information is available to assess whether these concerns are warranted. Samples of breast milk from 197 women from two cities in Ukraine were analyzed for p,p'-DDT, p,p'-DDE, endrin, dieldrin, heptachlor epoxide, trans-nonachlor, oxychlordane, hexachlorobenzene, ss-hexachlorocyclohexane (HCH), and 18 polychlorinated biphenyl congeners, and results were compared to previous reports from Europe. The median ss-HCH concentration was 731 ng/g milk fat, which is higher than other reports from Europe but lower than reports from other parts of the world. The median DDE concentration was 2,457 ng/g milk fat, which is higher than most but not all other reports from Europe. Concentrations of other chemicals were comparable to or lower than other reports from Europe. Concentrations from the city of Kyiv were generally lower than those from Dniprodzerzhinsk, but the magnitudes of these differences were modest.
Multum in Parvo.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ANATOMY AND PHYSIOLOGY.
Journal: JAMA (1883)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract P126: Relation of Depressive Symptoms to the Cross-Sectional and Longitudinal Association of Low Cardiovascular Risk with Subclinical Atherosclerosis - The Chicago Healthy Aging Study (CHAS)
Authors: Rosalba Hernandez, Norrina B Allen, Kiang Liu, Jeremiah Stamler, Kathryn J Reid, Phyllis C Zee, Donghong Wu, Joseph Kang, Daniel B Garside, Martha Daviglus
Journal: Circulation (2013)

Background: Previous findings on the association of depressive symptoms and subclinical cardiovascular disease (CVD) have been inconsistent. This study aimed to (1) examine the cross-sectional association between depressive symptoms (DS) and subclinical atherosclerosis in older age; and (2) determine whether presence of DS at older age relates to the long-term low-order association of favorable CVD risk factor profile (low-risk) at younger age with subclinical atherosclerosis in older age. Methods: CHAS participants (n=1,395) were examined in 1967-1973 (baseline) and 2007-2009 (follow-up). Baseline low-risk was defined as: (1) blood pressure ≤120/≤80 mmHg and no reported use of antihypertensive medication, (2) serum cholesterol &lt;200 mg/dL and no reported use of lipid-lowering medication, (3) BMI &lt; 25.0 kg/m 2 , (4) no diabetes, and (5) no smoking; not low-risk included all others. DS (≥16 on the Center for Epidemiologic Studies Depression Scale [CES-D]) and presence of coronary artery calcification (CAC) &gt;0 (determined by computed tomography) were assessed at follow-up. Results: Among 1,130 CHAS participants with complete data (mean follow-up age=71.1), 6.9% met criteria for DS. Individuals with DS reported lower sleep quality ( p &lt;0.0001) and were more likely to be African American (p&lt;0.0001). At older age, DS were not associated with CAC&gt;0 after multivariate adjustment ( p =0.38). Prevalence of DS did not vary significantly between baseline low-risk and not low-risk participants (5.8% and 7.2%, p =0.45). Regardless of late-life depressive symptom status, presence of CAC (indicated by CAC scores &gt; 0) was less likely among low-risk persons ( p =0.21) (Table 1). Results were consistent across different CAC score cut-points (data not shown). Conclusion: Depressive symptoms in older age were not associated with subclinical atherosclerosis or CVD risk status. Low CVD risk status in early-middle age was associated with lower CAC prevalence in older age among persons both with and without depressive symptoms.
This Week in &lt;EMPH&gt;JAMA&lt;/EMPH&gt;
Journal: JAMA (2007)

A Piece of My Mind"Like other residents, I had my share o f s c a r y a s w e l l a s e x h i l a r a t i n g moments during my first months of internship."From "Ghosts." SEE PAGE 1259 Medical News & PerspectivesHospitals are embracing palliative care, which can be delivered along with curative or life-prolonging therapies, as a way to improve patient satisfaction and reduce the costs of treatment for an aging population with complex health problems.
Increased risk of sudden infant death syndrome in older infants at weekends
Authors: Eva Af Ekenstam, Gerd Michaelsson, Roger Hallgren, P Stuyt, M Demacker
Journal: BMJ (1986)

decreased.The effect of etretinate on her amyloidosis possibly depends therefore on the anti-inflammatory activities of retinoids recently reviewed by Orfanos and Bauer3; inhibition of the mobility of granulocytes and their migration into the epidermis, reduction of DNA synthesis of human lymphocytes, and stimulation of monocytes and macrophages-inflamma- tory cells considered to be essential in the pathophysiology of psoriasis.I Dicken CH.Retinoids: a review.
The scalenus anticus syndrome and competitive swimming. Report of two cases
Authors: S. A. Frankel
Journal: JAMA (1971)

Two cases of scalenus anticus syndrome occurring in competitive free-style swimmers were relieved by scalenotomy and the patients were able to return promptly and successfully to swimming competition. This experience has suggested the mechanism of an apparent causal relationship between freestyle swimming and the scalenus anticus syndrome. In both patients, cessation of competitive swimming resulted in remission of symptoms. Scalenotomy, however, proved to be a simple and effective means of preserving their swimming careers.
Infectious Mononucleosis
Authors: Harry B. Greenberg
Journal: JAMA (1968)

In this monograph, Dr. Hoagland describes the clinical and laboratory manifestations of infectious mononucleosis. Based on his recorded personal experiences with 500 consecutive patients with this disease and on a comprehensive but highly selective review of the literature, he also clarifies the diagnostic requirements and corrects erroneous impressions of this commonly occurring ailment. According to Hoagland, fatal consequences may result from the misconception that in infectious mononucleosis abdominal pain simulates acute appendicitis. There should not be the slightest difficulty in distinguishing between infectious mononucleosis and appendicitis. Moreover, if severe, or even moderate, pain develops below the left costal margin of a patient with infectious mononucleosis, the diagnosis of a ruptured spleen should be considered. This timely and important book gives a succinct but nonetheless detailed account of infectious mononucleosis, its differential diagnosis, and its complications. Short but excellent chapters also summarize developments in knowledge concerning pathology, pathogenesis, etiology, and epidemiology
Comment
Authors: Philip Rubin
Journal: JAMA (1965)

The incidence of intraepithelial cancer is directly related to the development of an aggressive cytology program in any city or county. The gradual shift of cervical cancer from the invasive to the noninvasive stage means greater problems in histopathological diagnosis. Friedell has indicated the need for a specific terminology and an understanding of transitional changes and difficulties in defining what constitutes carcinoma-in-situ. Although he stressed the need for adequate pathological material, he did not dwell on the advantages of multiple biopsies with a square-jawed punch and cervical curettage as contrasted to sharp-knife conization. Multiple biopsies can be done as an office procedure with minimum personnel and equipment; they yield high diagnostic accuracy and few complications. Many gynecologists favor conization because of the completeness of the specimen and because this procedure has therapeutic as well as diagnostic value in most instances. With the spectrum of pathological findings in stage O cervical
MENSTRUATION AND THE "SAFE PERIOD"
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Practical Pediatrics. A Manual of the Medical and Surgical Diseases of Infancy and Childhood.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Offshore Schools Loan Regs Revamped
Authors: Andrew A. Skolnick
Journal: JAMA (1995)

AFTER YEARS of neglecting its congressionally mandated responsibility, the US Department of Education is putting the final touches on new regulations for determining which foreign medical schools are eligible to participate in the Federal Family Educational Loan (FFEL) program. However, these final touches may touch off angry protests as well as lawsuits if they accomplish what Congress has mandated in the Higher Education Act Amendment of 1992—to deny federally insured loans to students attending foreign medical schools that fail to meet the same standards US and Canadian schools must meet. Many of these "offshore" schools, which primarily enroll US citizens, depend heavily on tuition paid with FFEL program loans. These loans are the only federal educational assistance funds available to Americans studying abroad. At least some of these for-profit, offshore schools may not stay open if eligibility for the loan program is denied. To satisfy the new regulations, substandard schools
Scarring, disfigurement, and quality of life in long-term survivors of childhood cancer: A report from the Childhood Cancer Survivor Study.
Authors: K. E. Kinahan, L. K. Sharp, A. Didwania, K. Seidel, W. Leisenring, M. E. Lacouture, M. Stovall, L. L. Robison, K. R. Krull
Journal: Journal of Clinical Oncology (2011)

9038 Background: Survivors of childhood cancer are at risk for a host of chronic and often debilitating medical conditions. Less studied and understood late effects are treatment-related scarring, disfigurement and persistent hair loss, and their impact on the survivor’s health related quality of life. Methods: The prevalence of bodily scarring and persistent hair loss was examined in 14,358 survivors (63.5% ≥ 20 yrs old; 53.7% male) and 4,023 siblings from the Childhood Cancer Survivor Study cohort. Multivariable models were used to examine associations with demographic and cancer treatment variables. A subset of 7,178 survivors who completed a subsequent survey was used to evaluate the impact of disfigurement and hair loss on quality of life and emotional distress. Results: The percentage of self-reported scarring and disfigurement was significantly higher for survivors compared to siblings across all sites (all p-values <0.001) including head/neck (25.1% vs. 8.4%), arms/legs (18.3% vs. 10.2%), chest/abdomen (38.1% vs. 9.2%) and persistent hair loss (14.0% vs. 6.3%). In age-, sex-, and race-adjusted models, cranial radiation exposure ≥ 36 Gy increased the risk for head/neck disfigurement (RR 2.50; 95% CI 2.29-2.73) and persistent hair loss (RR 4.81; 95% CI 4.12-5.63). In survivors, persistent hair loss increased risk of depression (RR 1.38; 95% CI 1.12-1.70), anxiety (RR 1.63; 95% CI 1.26-2.12) and somatization (RR 1.42; 95% CI 1.18-1.71). Head/Neck disfigurement increased risk for somatization (RR 1.24; 95% CI 1.07-1.44). Reported limitations in daily functioning due to emotional symptoms was associated with head/neck disfigurement (p<0.001), arm/leg disfigurement (p=0.003) and persistent hair loss (p=0.001), controlling for sex, age, and cranial radiation therapy. Conclusions: Survivors of childhood cancer are at increased risk for disfigurement and persistent hair loss, which is associated with future emotional distress and reduced quality of life. Interventions facilitating coping skills and emotional adjustment, and management strategies for these sequelae may be warranted for survivors with these physical symptoms.
Students transferring into an American medical school. Remediating their deficiencies
Authors: P. L. Stillman
Journal: JAMA (1980)

Thirty US citizen foreign-trained medical students (USFMS) and eleven US-trained medical students (USMS) were accepted with advanced standing to the University of Arizona College of Medicine (UACM) in September 1978. Each student was required to meet predetermined mastery criteria in physical diagnosis skills during a six-week intensive training program before entering clinical clerkships. On entrance, USFMS showed severe deficiencies in physical examination and medical interviewing skills compared with both USMS and sophomore students at UACM. By the completion of the program, all differences between the USFMS and the USMS were nonsignificant, except for factual knowledge of pathophysiology. The transfer students received lower ratings than the UACM students on preceptorship evaluations and patient write-ups. Deficiencies in clinical skills of USFMS were reduced by a brief, intensive training program characterized by specific mastery criteria. (<i>JAMA</i>243:129-133, 1980)