tbuckley/cabot-search huggingface dataset:
Editorial Board
Authors: Shbana Rahman, Milena Nuti, Patrick Wilken, Katja Brose, Ellie Carr, Jessica Jones, Lara Crow, Matt Mccutcheon, Philip Patenall, Neill Sharp, R Adolphs, R Baillargeon, D Chalmers, N Chater, J Cohen, A Engel, R French, A Friederici, M Goodale, M Hauser, R Jackendoff, S Kosslyn, N Logothetis, J Mcclelland, L Nadel, U Arizona, Usa Pinker, Z Pylyshyn, T Robbins, S Shamma, A Wagner, V Walsh, D Wolpert, J Trout, James Thompson, Jillian Hardee, Ben Newell, John Dunn, Julia Trommershäuser, Laurence Maloney, Michael Landy, Andrew Bremner, Nicholas Holmes, Charles Spence, Katja Wiech, Markus Ploner, Irene Tracey, Anil Seth, Zoltán Dienes, Axel Cleeremans, Morten Overgaard, Luiz Pessoa, Ken Cheng, Gustav Kuhn, Alym Amlani, Ronald Rensink, David Soto, Pia Rotshtein, John Hodsoll, Glyn Humphreys, Joel Pearson, Jan Brascamp
Journal: Trends in Cognitive Sciences (2008)
Docendo Discimus
Authors: Merrill G. Sosman
Journal: New England Journal of Medicine (1956)

ONE hundred and fifty years ago this society established an Annual Lecture, known variously as the Annual Discourse, Annual Dissertation and Annual Oration. With a few exceptions, this annual communication has been presented each year, usually at the time of the annual meeting. For some reason or other the oration was omitted six times between 1813 and 1833, and again in the year 1945, when the annual meeting was canceled because of war regulations on travel. According to my calculations, therefore, 145 annual dissertations have been given, and this is the 146th, on the 175th anniversary of the founding of . . .
Bevacizumab (BEV) plus chemotherapy (CT) continued beyond first progression in patients with metastatic colorectal cancer (mCRC) previously treated with BEV plus CT: Results of a randomized phase III intergroup study (TML study).
Authors: Dirk Arnold, Thierry Andre, Jaafar Bennouna, Javier Sastre, Pia J. Osterlund, Richard Greil, Eric Van Cutsem, Roger Von Moos, Irmarie Reyes-Rivera, Belguendouz Bendahmane, Stefan Kubicka
Journal: Journal of Clinical Oncology (2012)

CRA3503 Background: BEV in combination with fluoropyrimidine-based CT is standard treatment for mCRC in the first-line (1L) and BEV-naïve second-line (2L) settings. This is the first randomized study evaluating the benefit of continuing BEV in combination with standard CT as 2L treatment for patients with mCRC who progressed after receiving a standard BEV-containing regimen in the 1L setting. Methods: Patients with unresectable, histologically confirmed mCRC who progressed within 3 months after discontinuation of 1L BEV + CT were randomised to 2L fluoropyrimidine-based CT ± BEV (2.5 mg/kg/wk equivalent). Choice of oxaliplatin- or irinotecan-based 2L CT was dependent on the regimen used in 1L (crossover) and included as a stratification variable. The primary endpoint was overall survival (OS); secondary endpoints included progression-free survival (PFS), response rate and safety. Results: 820 patients were randomized from February 2006 to June 2010 (409 to BEV + CT and 411 to CT alone). Baseline patient and disease characteristics were well balanced between arms. The study met its primary endpoint; median OS was 11.2 months for BEV + CT and 9.8 months for CT (HR=0.81; 95% CI 0.69–0.94; unstratified log-rank test, p=0.0062). Median PFS was 5.7 months for BEV + CT and 4.1 months for CT (HR=0.68; 95% CI 0.59–0.78; unstratified log-rank test, p&lt;0.0001). The response rate was 5.4% for BEV + CT and 3.9% for CT (unstratified Chi-Square Test, p=0.3113). The adverse event profile was consistent with previously reported data for BEV + CT. Compared with historical data from BEV treatment in 1L or 2L mCRC, BEV-related adverse events were not increased when continuing BEV beyond progression. Conclusions: This is the first randomized study to prospectively investigate the impact of continuing BEV treatment in 2L mCRC for patients who progressed after receiving a BEV-containing regimen in 1L. Our findings demonstrate that BEV + CT (crossed over from 1L regimen) continued beyond progression significantly prolongs OS and PFS in 2L mCRC. Additional analysis (including biomarker evaluation) is ongoing.
"PURE FOODS."
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
"INOCULATION AGAINST HAY-FEVER"
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Error in Table 2
Journal: JAMA Network Open (2019)

Julie C. Lauffenburger, PharmD, PhD; Jennifer Lewey, MD, MPH; Saira Jan, MS, PharmD; Sagar Makanji, PharmD; Christina A. Ferro, PharmD; Alexis A. Krumme, MS, ScD; Jessica Lee, BA; Roya Ghazinouri, PT, DPT, MS; Nancy Haff, MD; Niteesh K. Choudhry, MD, PhD
Centrifugal Fibers of the Human Optic Nerve
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abdominal Surgery
Authors: Claude E. Welch
Journal: New England Journal of Medicine (1962)

THE innumerable articles that have appeared on various phases of abdominal surgery within the past two years consider many concepts and recommendations of technics that are of great interest at the present time, even though some eventually are sure to be discarded. This review devotes particular attention to those areas of controversy, and covers the period after the last report in this series.1 Stomach and DuodenumHiatus HerniaThe great frequency of such hernias and the prevalence of epigastric symptoms in the general population have led, in many quarters, to the belief that repair of the hernia will relieve the . . .
Calcium Metabolism and Calcium Therapy.
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Behavioral factors and urinary tract infection
Authors: K. Adatto
Journal: JAMA (1979)

Voiding and sexual habits of 84 female university students with a history of recurrent urinary infection were compared with those of a control group. There was one highly significant difference between the two groups: 61% of the patients but only 11% of the controls gave a history of regular voluntary deferral of micturition for periods of one hour to longer than six hours. Sexual practices among patients and controls were remarkably similar. A behavioral regimen stressing regular, complete bladder emptying was shown to be effective in preventing reinfection in the patient group. Voluntary urinary retention may play a pathogenic role in women with recurrent urinary tract infection, and its correction may play an important part in the management of urinary tract infection. (<i>JAMA</i>241:2525-2526, 1979)
Regulatory Ozone Modeling: Status, Directions, and Research Needs
Authors: Panos G. Georgopoulos
Journal: Environmental Health Perspectives (1995)

The Clean Air Act Amendments (CAAA) of 1990 have established selected comprehensive, three-dimensional, Photochemical Air Quality Simulation Models (PAQSMs) as the required regulatory tools for analyzing the urban and regional problem of high ambient ozone levels across the United States.These models are currently applied to study and establish strategies for meeting the National Ambient Air Quality Standard (NAAQS) for ozone in nonattainment areas; State Implementation Plans (SIPs) resulting from these efforts must be submitted to the U.S. Environmental Protection Agency (U.S. EPA) in November 1994.The following presentation provides an overview and discussion of the regulatory ozone modeling process and its implications.First, the PAQSM-based ozone attainment demonstration process is summarized in the framework of the 1994 SIPs.Then, following a brief overview of the representation of physical and chemical processes in PAQSMs, the essential attributes of standard modeling systems currently in regulatory use are presented in a nonmathematical, self-contained format, intended to provide a basic understanding of both model capabilities and limitations.The types of air quality, emission, and meteorological data needed for applying and evaluating PAQSMs are dis- cussed, as well as the sources, availability, and limitations of existing databases.The issue of evaluating a model's performance in order to accept it as a tool for policy making is discussed, and various methodologies for implementing this objective are summarized.Selected interim results from diagnostic analyses, which are performed as a component of the regulatory ozone modeling process for the Philadelphia-New Jersey region, are also presented to provide some specific examples related to the general issues discussed in this work.Finally, research needs related to a) the eval- uation and refinement of regulatory ozone modeling, b) the characterization of uncertainty in photochemical modeling, and c) the improvement of the model-based ozone-attainment demonstration process are presented to identify future directions in this area.
Gout
Authors: Ryszard M. Pluta, Alison E. Burke, Richard M. Glass
Journal: JAMA (2010)

Uric acid crystalsThe JAMA Patient Page is a public service of JAMA.The information and recommendations appearing on this page are appropriate in most instances, but they are not a substitute for medical diagnosis.For specific information concerning your personal medical condition, JAMA suggests that you consult your physician.This page may be photocopied noncommercially by physicians and other health care professionals to share with patients.To purchase bulk reprints, call 312/464-0776.
Meta-Analysis of Rat Lung Tumors from Lifetime Inhalation of Diesel Exhaust
Authors: Peter A. Valberg, Edmund A. C. Crouch
Journal: Environmental Health Perspectives (1999)

Estimating the carcinogenic potential of exposure to diesel-engine exhaust particulates (DEPs) is problematic. In rats, high concentrations of DEPs (> 1,000 microg/m(3)) inhaled over a lifetime result in excess lung tumors. However, data for rats exposed to DEP at concentrations not associated with lung overload are consistent with no tumorigenic effect. Individual rat studies have only a limited number of exposure groups; therefore, we combined the tumor data from eight chronic inhalation studies in a meta-analysis. Statistical analysis identified a threshold of response between 200 and 600 microg/m(3) average continuous lifetime exposure, consistent with biological-effect thresholds reported by other investigators. Our exposure-response analysis of all rats with < 600 microg/m(3) average continuous lifetime exposure found no tumorigenic effect of DEP in these rats. When we evaluated all rat studies, accounted for a threshold and for inhomogeneity between experiments, and expressed the results in terms of human unit risk (UR), we found a negative maximum-likelihood human UR of -32 (times) 10(-6) per microgram per cubic meter (microg/m(3)), but this was not statistically significantly different from zero. Extrapolating the rat upper 95th percentile confidence limit to humans gave an upper-bound human UR of 9.3 (times) 10(-6) per microg/m(3)]. This upper-bound human UR, derived from all of the data points (including 1,087 animals below the estimated threshold and 1,433 in the control groups), falls entirely below the range of estimates derived from lung-overloaded rats or from epidemiology of railroad workers. Our meta-analysis of the low-exposure data in rats does not support a lung cancer risk for DEP exposure at nonoverload conditions. Average ambient concentrations of DEP (0-3 microg/m(3)) are < 1% of the concentration associated here with a threshold of tumor response in the rat bioassay.
Incorrect Data
Authors: Alok Tiwari, Will Lester, Tjun Tang
Journal: JAMA (2018)

Paul D. Brown, MD; Kurt Jaeckle, MD; Karla V. Ballman, PhD; Elana Farace, PhD; Jane H. Cerhan, PhD; S. Keith Anderson, MS; Xiomara W. Carrero, BS; Fred G. Barker II, MD; Richard Deming, MD; Stuart H. Burri, MD; Cynthia Ménard, MD; Caroline Chung, MD; Volker W. Stieber, MD; Bruce E. Pollock, MD; Evanthia Galanis, MD; Jan C. Buckner, MD; Anthony L. Asher, MD
Glucagon
Authors: George F. Cahill
Journal: New England Journal of Medicine (1973)

Until recently endocrinology has been concerned with the pathophysiology induced by a number of different hormones, in excess or deficit, and with their subsequent isolation and characterization. Insulin, parathormone and aldosterone are excellent examples. Today, we find ourselves in a reverse situation, with hormones such as thyrocalcitonin and glucagon chemically identified, accurate assays for their concentrations available, but their possible roles in normal or abnormal physiology awaiting clarification.Glucagon, the hormone produced by the alpha cells of the pancreatic islets, is extremely potent, as little as 0.1 mg infused into man over a 24-hour period being capable of causing small . . .
Title Page / Table of Contents
Authors: Norihiro Kokudo, Brice Gayet, Yoo-Seok Yoon, Jai Young Cho, Dae Wook Hwang, Yoshinori Inagaki, Norihiro Kokudo, Kiyoshi Hasegawa, Yasuhiko Sugawara, Wei Tang, Shigekazu Takemura, Chikaharu Sakata, Yorihisa Urata, Takahiro Uenishi, Jean-Nicolas Vauthey, Takeaki Ishizawa, Junichi Kaneko, Taku Aoki, Kiyoshi Hasegawa, Matteo Donadon, Guido Torzilli, Yasuhiko Sugawara, Norihiro Kokudo, Shoji Kubo, Andrew A. Gumbs, Peipei Song, Jianjun Gao, Junichi Shindoh, Ahmed Kaseb, Ho-Seong Han, Yoshihiro Mise, Yoshihiro Sakamoto, Mengensatzproduktion
Journal: Liver Cancer (2013)
Radioisotope scanning of the thyroid
Authors: J. L. Quinn
Journal: JAMA (1967)

In 1951 Cassen reported the successful imaging of the thyroid gland by means of compounds containing radioactive iodine and a mechanical moving detector. The many technical advances in radioisotope detectors which has occurred since then, as well as our greater knowledge of thyroid pathophysiology, have improved the thyroid scan so that today it is an important diagnostic tool in the evaluation of thyroid disease. The thyroid scan can be used for in vivo determination of thyroid size, location, function, and position. <h3>Instrumentation</h3><h3>Rectilinear Scanners.—</h3> The most common type of radiation detector for thyroid imaging is the rectilinear scanner with a focusing collimator. The patient is given a tracer dose of a compound containing thyroid-seeking radioisotope. The detector moves stepwise over the neck of the patient and records, point by point, the distribution of radioactivity. The data is displayed as dots or dashes on paper or as varying degrees of density
Social Medicine and Medical Economics
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Methoxyflurane
Authors: Frank W. Setchell
Journal: JAMA (1971)

<h3>To the Editor.—</h3> Recent articles<sup>1,2</sup>inThe Journaland elsewhere calling attention to the possibility of nephrotoxicity of methoxyflurane do, indeed "suffer from a common information gap," as Goldman<sup>3</sup>has described it. The reader does not know what concentration, nor duration, nor whether relaxants were used, etc, in the cases reported. Another piece of information is also missing: whether any, or all, of these patients received tetracycline in conjunction with their methoxyflurane anesthetic. Work reported at the 1970 Annual Meeting of the Southern Society of Anesthesiologists by Kuzucu<sup>4</sup>strongly suggests that the combination of these two drugs may well result in renal failure, with characteristic autopsy findings of calcium oxalate crystals in the kidney.
Tacrine for Alzheimer's Disease-Reply
Authors: Margaret A. Winker
Journal: JAMA (1994)

<h3>In Reply.</h3> —In response to Dr Wolferman and Dr Temianka,<i>JAMA</i>recognizes that pharmaceutical manufacturers conducting studies on drugs they manufacture have a vested interest in demonstrating efficacy of the drug. Conflicts of interest may be obvious, as in this case, or more subtle.<sup>1</sup>Therefore,<i>JAMA</i>requires all authors to sign the financial disclosure statement<sup>2</sup>and includes all pertinent information in a footnote as part of the article. However, simply because an individual or company has a conflict does not mean they cannot conduct legitimate research. One purpose of editing and peer review is to evaluate reports of studies for possible biases and flaws and select those with the best science. This study met that test. Specific criteria to assess the quality of drug studies in the literature were recently published by Cho and Bero.<sup>3</sup> Investigators increasingly must depend on nongovernmental funds to conduct research. We choose
Bacterial translocation in acute liver injury induced by - galactosamine
Authors: F KASRAVI
Journal: Hepatology (1996)

Acute liver injury is associated with a high rate of infectious and septic complications. Most of these infections are produced by gram negative enteric bacteria. We evaluated bacterial translocation, intestinal permeability, blood flow, portal pressure, and intestinal microflora after induction of liver injury and 70% liver resection in the rat. The rate of translocation to both portal and arterial blood was 100% at 24 hours and 50% at 48 hours after liver resection compared with 83% to portal vein and 50% to aortic blood at both time points after acute liver injury. Translocation to intraabdominal organs (liver, spleen, and mesenteric lymph nodes) was 100% in both groups at both 24 and 48 hours. The rate of translocation increased after liver injury at 48 hours with progression of the liver injury but was decreased in the 70% liver resection group with improvement of liver function. "Total aerobic" and "total anaerobic" bacterial counts in small intestine and cecum were not affected. Pulmonary, distal small intestine, and cecal blood flow were decreased in both groups, whereas blood flow in the proximal small intestine was unaffected. Portal pressure and flow were increased after 70% liver resection, but they were decreased in acute liver injury. After acute liver injury, permeability of both distal small intestine and cecum increased, but after liver resection only cecal permeability increased. The results of this experiment show that bacterial translocation occurs in experimental acute liver injury and that its dynamic, pattern and fate are different from that observed after liver resection, which is a reversible surgical model of liver insufficiency. (Hepatology 1996 Jan;23(1):97-103)