tbuckley/cabot-search huggingface dataset:
Minerva
Authors: Lyndsey Paul, Calum Lyon
Journal: BMJ (2007)

Calcitonin gene-related peptide (CGRP) has a potent vasodilatory effect that is mediated by specific receptors predominantly coupled to the activation of adenylate cyclase. The effects of volatile anesthetics on CGRP-induced vasodilation are unclear. We studied the effects of sevoflurane and isoflurane on CGRP-induced vasodilation in pithed rats and CGRP receptor-mediated responses in SK-N-MC cells, which are used as a model system to study the CGRP receptor and its downstream pathways. Male Wistar rats were pithed by inserting a stainless steel rod into the spinal cord. Mean arterial pressure (MAP) and cardiac output were maintained at approximately 100 mm Hg and 50 ml · min<sup>–1</sup>, respectively, with continuous infusion of noradrenaline. After 30 min of inhalation of anesthetics, CGRP (0.1, 0.3, 1.0, and 3.0 μg/kg) was administered intravenously. In SK-N-MC cells, CGRP-, forskolin-, or cholera toxin-induced cAMP production was measured with or without anesthetics using radioimmunoassays. CGRP receptor binding density and affinity for the agonist were determined with (2-[<sup>125</sup>I]iodohystidyl<sup>10</sup>) CGRP with or without the anesthetics. Sevoflurane (4%) and isoflurane (2%) significantly inhibited the decrease in MAP and systemic vascular resistance. Furthermore, both anesthetics significantly inhibited CGRP- but not forskolin-induced cAMP production. Sevoflurane (4%) and isoflurane (4%) significantly inhibited cholera toxin-induced cAMP production. Both anesthetics did not affect ligand binding. These data suggest that sevoflurane and isoflurane inhibit CGRP-induced vasodilation at the site between the CGRP receptor and adenylate cyclase activation. The inhibitory site of volatile anesthetics on the CGRP receptor-mediated response involves G<sub>s</sub> protein.
A parent's story: "I felt lost and hysterical"
Journal: BMJ (2003)

Description Head lice are parasites that usually infest the scalps of school age children, although adults also get them.Lice attach their eggs to hair shafts near the scalp and lay five to six eggs a day.Lice never willingly leave the head; they stay close to the scalp for food, shelter, warmth, and moisture.They are most often found behind the ears and at the back of the neck.Hatched eggshells (nits) may be confused with dandruff.The mature louse is the size of a sesame seed and has six legs and hook-like claws that grasp the strand of hair tightly, making it difficult to dislodge.It feeds on the host's blood every three to six hours, which can cause scalp itching, though most cases are asymptomatic.The diagnosis of lice infestation can be made definitively only if living lice are present. Treatment Treatments that are likely to work MalathionMalathion works as well as other agents used to kill lice.Malathion must be left on for at least eight hours for it to work.It is applied to dry hair until the scalp and hair are wet and thoroughly coated.If lice are found 7-10 days after treatment, treat again with the same or different medication.The alcohol in malathion lotion and the terpenoids may cause stinging.Malathion is considered safe in pregnancy or breastfeeding.
Are physicians advising smokers to quit? The patient's perspective
Authors: R. F. Anda
Journal: JAMA (1987)

Physicians can play an important role in smoking cessation because they have frequent contact with smokers and because most smokers believe that a physician's advice is important in the decision to quit. Therefore, to determine smokers' perceptions of physician involvement in smoking cessation, we analyzed aggregate data from two random statewide surveys of 5875 Michigan adults. Of smokers who had seen a physician in the previous year, only 44% reported that they had ever been told to quit smoking by a physician. Young male smokers were the least likely (30%) to have been told to quit. Smokers who were hypertensive, obese, diabetic, sedentary, or users of oral contraceptives were no more likely to have been told to quit than smokers without these additional cardiovascular risks. Conversely, smokers who had survived a myocardial infarction or stroke were more likely to have been told to quit than smokers who had not suffered these events (73% vs 43%). Most smokers do not perceive physicians to be even minimally involved in their efforts to quit. Physicians need to increase their efforts in counseling smokers to quit before smoking-related diseases result, especially for smokers with additional risk factors for cardiovascular disease. (<i>JAMA</i>1987;257:1916-1919)
Fundamentals of Organic and Biologic Chemistry.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Contemporary Correction
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pediatrics
Authors: J. S. Andrews
Journal: JAMA (1995)

The attention of pediatricians continues to be called to the harmful effects of cigarette smoke in children. Maternal smoking during pregnancy is associated with higher rates of spontaneous abortion, premature rupture of membranes, stillbirth, low birth weight, and sudden infant death syndrome. During infancy and childhood, exposure to environmental tobacco smoke increases the risk of upper respiratory tract infection, middle-ear effusion, asthma, and lower respiratory tract infection. Children with asthma have more severe manifestations of disease when exposed to environmental tobacco smoke. During later childhood and adolescence, children themselves may begin to smoke, assuming risks of long-term pulmonary dysfunction and lung cancer similar to those observed in adults.<sup>1</sup> In the United States, 27% of women in their childbearing years smoke cigarettes.<sup>2</sup>Previous attempts have been made to relate neurodevelopmental deficits to maternal cigarette smoking during pregnancy and early infancy. These studies have been confounded by failure to separate
Errors in Table
Authors: Steven Narod, Vasily Giannakeas, Victoria Sopik
Journal: JAMA Oncology (2019)

Takayuki Yoshino, MD, PhD; Takeharu Yamanaka, PhD; Eiji Oki, MD, PhD; Masahito Kotaka, MD, PhD; Dai Manaka, MD, PhD; Tetsuya Eto, MD; Junichi Hasegawa, MD, PhD; Akinori Takagane, MD, PhD; Masato Nakamura, MD, PhD; Takeshi Kato, MD, PhD; Yoshinori Munemoto, MD, PhD; Shintaro Takeuchi, MD, PhD; Hiroyuki Bando, MD, PhD; Hiroki Taniguchi, MD, PhD; Makio Gamoh, MD, PhD; Manabu Shiozawa, MD, PhD; Tsunekazu Mizushima, MD, PhD; Shigetoyo Saji, MD, PhD; Yoshihiko Maehara, MD, PhD; Atsushi Ohtsu, MD, PhD; Masaki Mori, MD, PhD
Self-Reported Hearing Loss Among Workers Potentially Exposed to Industrial Noise—United States
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Book Reviews
Journal: British Journal of Dermatology (1980)

British Journal of DermatologyVolume 102, Issue 6 p. 753-755 Book Reviews First published: June 1980 https://doi.org/10.1111/j.1365-2133.1980.tb06578.xAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Book-review in this article: Techniques in Skin Surgery Practical Pediatric Dermatology Techniques in Skin Surgery Morphological Dermatology Microbial Disease: The Use of the Laboratory in Diagnosis, Therapy and Control Morphological Dermatology. A study of the Living Gross Pathology of the Skin Microbial Disease: The Use of the Laboratory in Diagnosis, Therapy and Control Reactions of the Skin to Cosmetic and Toiletry Products Pigment Cell. Volume 4: Biologic Basis of Pigmentation. Volume 5: Pathophysiology of Melanocytes Volume102, Issue6June 1980Pages 753-755 RelatedInformation
Correspondence
Authors: A. Kay
Journal: Annals of the Rheumatic Diseases (1976)

Sir,The now common use of penicillamine in the treatment of rheumatoid arthritis makes it important to minimize the risk of serious adverse reaction to the drug.A few severe and/or fatal blood dyscrasias have already occurred.I am collecting information on patients who have developed aplastic anaemia, leucopenia, granulocytopenia, or thrombocytopenia attributable to penicillamine.I would be most grateful to your readers for details of any such patients under their care.
Influence of Exposure Mode on the Toxicity of NO 2
Authors: D. E. Gardner, F. J. Miller, E. J. Blommer, D. L. Coffin
Journal: Environmental Health Perspectives (1979)

PoUlutant gases are subject to a variety of physical and chemical interactions within the atmosphere due to cyclic production and various meteorological influences.In consequence there is generally a diurnal concentration profile for NO2 which consists of peaks of short duration and irregular occurrence superimposed on a low background.Since this variation could play an important role in the toxic effect of NO2, the influences of various exposure modes was studied.Continuous and intermittent exposure studies were used to determine the relationship between biological response and length of exposure to various concentrations of NO2.As the concentration decreased, the slope of the regression line decreased.After adjusting for total differences in the product concentration x time, the response for the two exposure modes was essentiaUly the same.When a constant concentration x time level was employed, a short-term exposure to a high concentration produced a greater effect than exposure to a lower concentration administered over a longer period.Using these curves, the relationship between level of effect, concentra- tion, and time can be determined.Results of these studies indicated that the frequency and amplitude of short-term peaks are of significance even though the exposure is interrupted with periods of zero concentration of NO2.
ITALY
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prophylactic Aspirin?
Authors: M. JEFFREY FRANK
Journal: Annals of Internal Medicine (1973)

Comments and Corrections1 March 1973Prophylactic Aspirin?M. JEFFREY FRANK, M.D., NATHAN FRANK, M.D., F.A.C.P.M. JEFFREY FRANK, M.D.Search for more papers by this author, NATHAN FRANK, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-78-3-462_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: To date a few pharmacologic agents have been found that effectively prevent the aggregation and reduce the "stickiness" of platelets: dipyridamole, Malayan cobra snake venom, and aspirin. To prove the efficacy of these drugs for prophylaxis of coronary artery thrombosis would require a trial of large numbers of patients over a period of several years. Valuable time lost! There is an indirect means that may help convince competent cardiac investigators that aspirin therapy is worthy for treatment of patients with potential or established ischemic heart disease due to coronary artery disease.We suggest a study on this... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1973Volume 78, Issue 3Page: 462-462KeywordsAspirinCoronary arteriesDrugsHeart diseasesPatientsPlateletsProphylaxisStable coronary artery diseaseThrombosisVenoms Issue Published: 1 March 1973 PDF DownloadLoading ...
Status asthmaticus in children
Authors: W. Richards
Journal: JAMA (1967)

An analysis was made of admission rates and patients hospitalized for status asthmaticus at the Children's Hospital of Los Angeles. Despite reports of increasing morbidity and mortality due to status asthmaticus, no significant trend in the admission rate was noted. However, seasonal increases of asthma admissions did occur (October and November), but the increases could not be fully correlated with any environmental factors. In a study of 142 patients, 41 (31%) of the 131 patients who had roentgenograms showed evidence of pneumonitis, suggesting infection as an important factor in status asthmaticus. Acidosis, hypoxia, and hypercapnia result from severe asthma, and frequent clinical and laboratory monitoring of the condition of asthma patients for these serious complications is essential. In addition to the customary treatment of asthma, these abnormalities may be combated by assisted ventilation (intermittent positive pressure breathing by mask or endotracheal tube), muscle relaxants, and alkalizing agents (sodium bicarbonate or tromethamine).
Abstract 4519: The reciprocal interaction between neutrophil extracellular traps and cancer cells impacts on their malignant potentials
Authors: Hiroki Kajioka, Shunsuke Kagawa, Atene Ito, Kazuya Kuwada, Satoru Kikuchi, Shinji Kuroda, Ryuichi Yoshida, Hiroshi Tazawa, Toshiyoshi Fujiwara
Journal: Cancer Research (2019)

Abstract Although the neutrophil extracellular traps (NETs) are first recognized to function to trap invading microorganisms and eliminate them as a defense mechanism, the involvement of NETs in cancer metastasis is being elucidated. The mechanism of interaction between NET and cancer cells, however, remains to be fully understood. Here, we investigated the direct and indirect interaction between NETs and cancer. NETs were detected in surgically resected metastatic liver cancer tissue specimens. In direct co-culture, NETs actually attracted cancer cells with their web-like structure. Of note, indirect transwell co-culture of neutrophils and pancreatic cancer cells provoked NETs without the other stimuli. In addition, conditioned media derived from cancer cells also induced NETs. The co-culture of NETs and cancer cells dramatically accelerated their migration and invasion abilities. Further investigation revealed that NETs induced mesenchymal markers in cancer cells which was associated with upregulated epithelial to mesenchymal transition (EMT)-related transcriptional factors. Finally, the accelerated cancer migration and overexpression of mesenchymal markers induced via NETs were inhibited by pharmacological blockade of NETs including NADPH oxidase inhibitor, peptidylarginine deiminase inhibitor, and neutrophil elastase inhibitor. These results suggested that cancer cells and neutrophils reciprocally interact when they coexist and NETs drive malignant potentials via EMT, implicating NETs as a candidate therapeutic target. Citation Format: Hiroki Kajioka, Shunsuke Kagawa, Atene Ito, Kazuya Kuwada, Satoru Kikuchi, Shinji Kuroda, Ryuichi Yoshida, Hiroshi Tazawa, Toshiyoshi Fujiwara. The reciprocal interaction between neutrophil extracellular traps and cancer cells impacts on their malignant potentials [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4519.
Primary Care of Women
Authors: Charlea T. Massion
Journal: JAMA (1996)

Despite the debates over which specialty "owns" women's health care and whether there should be a new, separate specialty in women's health, and despite the daily rearrangement of health systems by managed care corporations, many primary care physicians are attempting to provide more comprehensive health care to women. These exemplary endeavors by some internists, family physicians, allied health professionals, and a few gynecologists bring a much wider scope of issues into primary care. The three books reviewed herein exemplify this clinical trend beyond the traditional biomedical paradigm to a truly biopsychosocial model of women's health. The texts imply that today's ideal primary care provider for women is expected not only to know about medical and gynecologic health and disease, but also to screen for and treat a complex spectrum of psychosocial conditions. This model of care leaps far beyond the standard breast exam, Pap test, and blood pressure check. Consider,
The Protection of Micro-Organisms
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Antonio Maria Valsalva (1666-1723) Valsalva Maneuver
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal