tbuckley/cabot-search huggingface dataset:
Choice of cancer therapy varies with age of patient
Authors: J. Samet
Journal: JAMA (1986)

We used data on 22,899 cancer cases collected by the New Mexico Tumor Registry to examine the relationship between patient age and the use of potentially curative therapy for cancers of selected sites and acute leukemias. For cancers of most sites, either local or regional stage, the proportion of cases receiving potentially curative therapy declined with age. For local-stage cancers, the proportion not given any treatment increased with age. Overall mortality rates during the first year after diagnosis were much higher for local-stage cases without treatment than for those who received treatment. These data show that cancer therapy varies with age and suggest that decision making regarding therapy is influenced by the presence of other diseases. (<i>JAMA</i>1986;255:3385-3390)
Index of Authors&lt;subtitle&gt;Volume 24 January 1960 • June 1960&lt;/subtitle&gt;
Journal: JNCI Journal of the National Cancer Institute (1960)

Index of Authors: Volume 24 January 1960 • June 1960 JNCI: Journal of the National Cancer Institute, Volume 24, Issue 6, June 1960, Pages 1451–1453, https://doi.org/10.1093/jnci/24.6.1451 Published: 01 June 1960
Spontaneous Fractures of the Femoral Neck
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Air Pollution and Daily Mortality in Three U.S. Counties
Authors: Suresh H. Moolgavkar
Journal: Environmental Health Perspectives (2000)

I used generalized additive models to analyze the time-series of daily total nonaccidental and cause-specific (cardiovascular, cerebrovascular, and chronic obstructive pulmonary disease) deaths over the period 1987-1995 in three major U.S. metropolitan areas: Cook County, Los Angeles County, and Maricopa County. In all three counties I had monitoring information on particulate matter [less than/equal to] 10 microm (PM(10)), carbon monoxide, sulfur dioxide, nitrogen dioxide, and ozone. In Los Angeles, monitoring information on particulate matter [less than/equal to] 2.5 microm (PM(2.5)) was available as well. I present the results of both single and multi-pollutant analyses. Air pollution was associated with each of the mortality end points. With respect to the individual components of the pollution mix, the results indicate considerable heterogeneity of air pollution effects in the different geographic locations. In general, the gases, particularly CO, but not ozone, were much more strongly associated with mortality than was particulate matter. This association was particularly striking in Los Angeles County.
American Journal of Medicine, New York
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Infection Control in Intravenous Therapy.
Authors: Dennis G. Maki
Journal: Annals of Internal Medicine (1973)

Meeting Abstracts1 May 1973Infection Control in Intravenous Therapy.Dennis G. Maki, M.D., Donald A. Goldmann, M.D., Frank S. Rhame, M.D., John V. Bennett, M.D.Dennis G. Maki, M.D., Donald A. Goldmann, M.D., Frank S. Rhame, M.D., John V. Bennett, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-78-5-825_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptBetween summer 1970 and March 1971, 394 patients in 25 hospitals in the United States experienced 412 episodes of nosocomial Gram-negative septicemia while receiving intravenous (IV) infusion products from one manufacturer. The epidemic was traced by the Center for Disease Control to intrinsic contamination of a newly introduced screw cap for the infusion bottles. In our investigations many new clinical and microbiologic observations were found to be applicable to the prevention of intravenous-associated septicemia.1. These septicemias are clinically indistinguishable from those of other causes except that patients with these infections frequently have no underlying predisposing diseases or overt sites... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Atlanta, Georgia. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1973Volume 78, Issue 5Page: 825-825KeywordsClinical microbiologyInfectious diseasesSepsis Issue Published: 1 May 1973 PDF DownloadLoading ...
Impact of Psychometrically Defined Deficits of Executive Functioning in Adults With Attention Deficit Hyperactivity Disorder
Authors: Joseph Biederman
Journal: American Journal of Psychiatry (2006)

Objective: The association between deficits in executive functioning and functional outcomes was examined among adults with attention deficit hyperactivity disorder (ADHD). Method: Subjects were adults who did (N=213) and did not (N=145) meet DSM-IV criteria for ADHD. The authors defined having deficits in executive functioning as having at least two measures of executive functioning with scores 1.5 standard deviations below those of matched comparison subjects. Results: Significantly more adults with ADHD had deficits of executive functioning than comparison subjects. Deficits of executive functioning were associated with lower academic achievement, irrespective of ADHD status. Subjects with ADHD with deficits of executive functioning had a significantly lower socioeconomic status and a significant functional morbidity beyond the diagnosis of ADHD alone. Conclusions: Psychometrically defined deficits of executive functioning may help identify a subgroup of adults with ADHD at high risk for occupational and academic underachievement. More efforts are needed to identify cost-effective approaches to screen individuals with ADHD for deficits of executive functioning.
Our Sex Life: A Guide &amp;amp; Counsellor for Everyone
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Results of a phase I trial of BAY 43–9006 in combination with oxaliplatin in patients with refractory solid tumors
Authors: P. Kupsch, K. Passarge, H. Richly, K. Wiesemann, R. A. Hilger, C. G. Haase, B. Schwartz, M. E. Scheulen, S. Seeber, D. Strumberg
Journal: Journal of Clinical Oncology (2004)

3056 Background:BAY 43–9006 (BAY) is a novel signal transduction inhibitor that prevents tumor cell proliferation and angiogenesis through blockade of the Raf/MEK/ERK pathway at the level of Raf kinase and the receptor tyrosine kinases VEGFR-2 and PDGFR-β. Previous single-agent phase I trials show BAY is well tolerated with manageable and reversible side effects, most commonly hand-foot skin (HFS) reaction, rash, fatigue, and diarrhea. This study was initiated to determine safety and pharmacokinetics (PK) of BAY in combination with oxaliplatin (OXAL). Methods:Patients (pts) received continuous BAY at 200 mg bid (cohort 1) followed by escalation to 400 mg bid (cohort 2) given with a fixed dose of OXAL at 130 mg/m2 q3wks. Results:24 pts (M:F ratio =16:8; median age 60.5 yrs range 32–73) entered the study. Common tumor types were CRC (21%), Mel (21%) and RCC (13%). Drug-related dose-limiting toxicities to either drug were gr 3 thrombocytopenia and gr 3 diarrhea in cohort 1 (thrombocytopenia 1/8 pts; diarrhea 1/8 pts) and in cohort 2 (thrombocytopenia 2/16 pts; diarrhea 1/8 pts). Other toxicities consisted of non-hematologic: gastrointestinal-92% (diarrhea-58%, nausea-50%), constitutional-71% (fatigue-38%), neurological-67% (sensory neuropathy-46%), pain-50%, dermatological-46%. Hematologic AEs were uncommon. Single infusions of 130 mg/m2 OXAL did not significantly alter the steady state PK profile of BAY following multiple oral doses of 200 and 400 mg bid BAY. Similarly, PK profiles of total and unbound platinum were not significantly influenced by concomitant multiple doses of BAY. Prolonged stabilization of previously progressive disease was obtained in 2/8 pts in cohort 1 and 5/16 pts in cohort 2. Two additional pts with gastric cancer (1 in each cohort) had partial responses according to modified WHO criteria. Conclusions:Continuous 400 mg bid BAY in combination with 130 mg/m2 OXAL (q3week) appears to be well tolerated with no clinically relevant PK interaction. Clinical activity has been observed and an extension in CRC pts is ongoing. The recommended dose of BAY for phase II studies in combination with OXAL is 400 mg bid BAY. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Bayer AG; Bayer Corp. Bayer AG Wuppertal, Germany
Officials of the Association—1963-1964
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Reporting of AIDS
Authors: S. Robert Lichter
Journal: JAMA (1989)

<h3>To the Editor.—</h3> The acquired immunodeficiency syndrome (AIDS) epidemic has generated not only an increasing flow of scientific articles, but of news stories as well. The public is largely dependent on the latter for information. How accurately do the news media report AIDS research findings, and how do news writers' own beliefs compare with those of the scientific community? <h3>Study.—</h3> To address these questions, using methodology developed in an earlier study,<sup>1</sup>we mailed brief confidential questionnaires to 103 medical researchers and 116 general scientists in the United States, randomly selected from<i>American Men and Women of Science</i>. The sample thus represented a range of respondents, from those directly involved with AIDS research to those trained in other scientific disciplines. The same questionnaire was also sent to 96 journalists, selected from leading US newspapers, news magazines, and television networks, who had reported on AIDS within the last year. Response rates
Plain language summaries
Journal: British Journal of Dermatology (2017)

Contact allergy occurs when the skin comes into contact with allergens causing sensitisation.This means that if the skin comes into contact with the same allergen again, it may develop an eczema-like reaction called allergic contact dermatitis.When a patient is suspected to suffer from allergic contact dermatitis, patch testing is used by dermatologists to find out what the substance causing the reaction might be.This is done by applying a range of known allergens to patches of the skin to see which lead to flare ups.Patients undergoing patch testing may have positive test results to more than one allergen, and positive results to specific pairs of allergens have been found, called allergen pair associations.This study, from the UK, explored the influence of time of testing, age, sex and atopy status (whether the person has asthma, hayfever and eczema) on allergen pair associations in 45 110 patients tested over 30 years.Of these patients, 9800 patients had reactions to one allergen and 8300 to two or more allergens.For 38 allergens, there are a total of 703 possible pair combinations.243 of these pairs were associated, meaning the patient had a positive reaction to both of them.Allergen pairs varied according to when the patient was tested, their age, sex and atopy status.This has important implications for understanding the triggers for contact allergy and understanding mechanisms of allergic sensitisation.
DEAFNESS IN CHILDHOOD
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reactive hypoglycemia and A-cell ('pancreatic') glucagon deficiency in the adult
Authors: P. P. Foa
Journal: JAMA (1980)

Serum glucose, A-cell (IRG<sub>A</sub>) and total glucagon (IRG<sub>T</sub>), insulin, growth hormone, cortisol, triiodothyronine, and thyroxine values were measured in the fasting state and in response to oral glucose, intravenously administered arginine, and a meal of pan-broiled ground beef in 31 symptomatic patients and 11 normal subjects. Twenty-four patients and 11 control subjects had normal glucose tolerance (group 1); seven patients had reactive hypoglycemia (group 2). Under all conditions, serum IRG<sub>A</sub>value was significantly lower in group 2 than in group 1. Glucose, arginine, or meat increased serum IRG<sub>T</sub>levels. This response did not differ significantly in the two groups, nor did the secretion of the other measured hormones. We conclude that A-cell insufficiency can contribute to reactive hypoglycemia in the adult. (<i>JAMA</i>244:2281-2285, 1980)
A Validation of Event-Related fMRI Comparisons Between Users of Cocaine, Nicotine, or Cannabis and Control Subjects
Authors: Kevin Murphy, Veronica Dixon, Kathleen LaGrave, Jacqueline Kaufman, Robert Risinger, Alan Bloom, Hugh Garavan
Journal: American Journal of Psychiatry (2006)

Objective: Noninvasive brain imaging techniques are a powerful tool for researching the effects of drug abuse on brain activation measures. However, because many drugs have direct vascular effects, the validity of techniques that depend on blood flow measures as a reflection of neuronal activity may be called into question. This may be of particular concern in event-related functional magnetic resonance imaging (fMRI), where current analytic techniques search for a specific shape in the hemodynamic response to neuronal activity. Method: To investigate possible alterations in task-related activation as a result of drug abuse, fMRI scans were conducted on subjects in four groups as they performed a simple event-related finger-tapping task: users of cocaine, nicotine, or cannabis and control subjects. Results: Activation measures, as determined by two different analytic methods, did not differ between the groups. A comparison between an intravenous saline and an intravenous cocaine condition in cocaine users found a similar null result. Further in-depth analyses of the shape of the hemodynamic responses in each group also showed no differences. Conclusions: This study demonstrates that drug groups may be compared with control subjects using event-related fMRI without the need for any post hoc procedures to correct for possible drug-induced cardiovascular alterations. Thus, fMRI activation differences reported between these drug groups can be more confidently interpreted as reflecting neuronal differences.
Psychiatry and the Tranquilizers
Authors: Anthony Hordern
Journal: New England Journal of Medicine (1961)

Discrepant FindingsAt the present time, the predominant academic orientation of psychiatry in the United States remains psychodynamic; in this regard Menninger's69 statement made in 1956 continues, in large measure, to obtain: "Today, American psychiatry is one based on a psychoanalytic theory of personality...." Earlier, in the 1930 edition of The Human Mind, in a similar vein, the same authority stated, "... practically no intelligent and informed scientist today disputes the main thesis and findings of psychoanalysis...." The American psychodynamic approach, of which the interpersonal theory of psychiatry described in a volume by Sullivan70 is a prominent development, may suitably . . .
Multiple calcified pulmonary nodules in an elderly man
Authors: J. Panella
Journal: JAMA (1980)

<h3>History</h3> A 76-year-old man had been treated for carcinoma of the prostate for approximately two years with radiation, bilateral orchiectomy, and chemotherapy. The patient had numerous previous roentgenograms of the chest, but the most recent examination of the chest was one year before the current examination, at which time no notable abnormality was noted. The posteroanterior chest roentgenogram shown in Fig 1 demonstrates multiple pulmonary nodules distributed widely throughout both lungs. The nodules showed variation in size and are sharply outlined. A close-up view shows punctate calcifications present in most of the nodules (Fig 2). <h3>Diagnosis</h3> Prostatic adenocarcinoma with metastatic pulmonary nodules containing calcification. <h3>Comment</h3> The patient underwent a fluoroscopically guided transthoracic needle biopsy, using a Chiba needle. The cytological study showed clusters of atypical glandular cells that were moderately well differentiated and compatible with prostatic adenocarcinoma. The original diagnosis had been established by aspiration of the prostate. The presence
Red Water
Authors: Eric Dyer
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correspondence
Journal: Hepatology (1983)

The real and potential values of the aminopyrine breath test (ABT) for clinical hepatology have been a matter of heated controversy for many years.Two major problems have fueled this dispute: first, the apparent lack of quantitative date to determine correctly sensitivity and specificity of the ABT as a screening test for a variety of liver diseases and, second, the widespread erroneous acceptance that 14COz formation directly reflects aminopyrine N-demethylation rates.The latter problem is particularly scientifically disturbing because of ignorance regarding the highly complex biochemical mechanisms which govern formaldehyde and formic acid oxidation to 14C02.In addition to the recent paper by Schoeller et al. ( 1) in Hepatology and the accompanying Editorial by Dr. Alan Hofmann (2), several other recent papers (3-5) contribute needed new data concerning the biochemistry of ABT.Results to be emphasized from