tbuckley/cabot-search huggingface dataset:
KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance
Authors: Kunihiko Hinohara, Hua-Jun Wu, None Sébastien Vigneau, Thomas O. McDonald, Kyomi J. Igarashi, Kimiyo N. Yamamoto, Thomas Madsen, Anne Fassl, Shawn B. Egri, Malvina Papanastasiou, Lina Ding, Guillermo Peluffo, Ofir Cohen, Stephen C. Kales, Madhu Lal-Nag, Ganesha Rai, David J. Maloney, Ajit Jadhav, Anton Simeonov, Nikhil Wagle, Myles Brown, Alexander Meissner, Piotr Sicinski, Jacob D. Jaffe, Rinath Jeselsohn, Alexander A. Gimelbrant, Franziska Michor, Kornelia Polyak
Journal: Cancer Cell (2019)
"VIA PADUA"
Authors: Egidio Meneghetti
Journal: JAMA (1960)

<h3>To the Editor:—</h3> InThe Journal, March 26, page 1393, there is an interesting article about Padua. I would like to correct a few mistakes that I noticed in it. About Pietro d'Abano, the author says: "No Via d'Abano commemorates him..." Actually, since 1933 there has been a Via Pietro d'Abano in Padua. Later on, about Harvey, the writer complains that "William Harvey, the most famous man ever to have studied at the University of Padua, had been neglected by the Senatus Populusque Padovensis when they assigned street names after illustrious residents." Senatus Populusque Padovensis (sic)— let us say Patavinus—assigned in 1954 the name of William Harvey to a street; in fact, we find in "Padua Street Guide, 1958," "Via Guglielmo Harvey (D. 1954) inglese, scolaro della nostra Università. Scopritore della circolazione del sangue ( 1578-1657)."
Propoxyphene Jaundice
Authors: George K. Daikos
Journal: JAMA (1975)

TO OUR knowledge, propoxyphene (dextropropoxyphene), a widely used analgesic, has been demonstrated as hepatotoxic in regular clinical use only once.<sup>1</sup>We wish to report another case of jaundice apparently caused by this drug. <h3>Report of Case</h3> On Nov 20, 1970, a 47-year-old man who had been suffering from sciatic pains for several years started taking a combination of orphenadrine citrate (35 mg), and paracetamol (450 mg) (Norgesic, as available in Greece), six to eight tablets daily, as well as propoxyphene hydrochloride (65 mg) (Doloxene, as available in Greece), three to four capsules daily. Three days later, he suddenly experienced an extremely severe upper abdominal pain of short duration, followed the next morning by dark urine, clay-colored stools, and gradual development of jaundice. No anorexia, nausea, or other gastrointestinal symptoms preceded or accompanied this episode, and the patient's temperature was normal. On examination, the liver was palpable 1 1/2 finger
Injuries
Authors: Leon S. Robertson
Journal: JAMA (1985)

<h3>To the Editor.—</h3> In his review of my book,<i>Injuries</i>, in the Sept 7 issue ofThe Journal, Theodore Doege<sup>1</sup>grossly misrepresents several of the book's topics. He says that the book "makes no mention... of a person's capability compared with the demands of the task at hand." A substantial portion of chapter 3, beginning with the heading "Human Limitations" (p 45), is devoted to that topic. On the grounds that "few knowledgeable public health physicians would advocate such a protocol for a new vaccine," Doege objects to my statement that some measures can be adopted on the basis of extensive laboratory experiments without controlled field trials. Apparently he would have awaited field trials to replace steering columns, which speared drivers in the chest, with energy-absorbing mechanisms. The point, substantially elaborated in the book, is that some hazards are so obvious that one does not need controlled field experiments
Neonatal Hepatitis and its Relation to Viral Hepatitis of Mother
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 107: Urinary β2 Microglobulin To Creatinine Ratio As A Predictive Factor Of Intravenous Immunoglobulin Resistance
Authors: Takahisa Yoshikawa, Kenji Waki, Kayo Ogino, Mariko Sawada, Tomohiro Hayashi, Yoshio Arakaki
Journal: Circulation (2015)

Introduction: The standard dose of intravenous immunoglobulin (IVIG) as initial therapy for patients with Kawasaki disease (KD) is generally 2 g/kg. In our hospital, the initial IVIG dose for patients with KD is 1 g/kg, which is augmented according to treatment response, and therapy is changed to plasma exchange (PE) if IVIG therapy over 6 g/kg is ineffective. To date, various factors and scoring systems for predicting IVIG resistance have been reported. We evaluated consecutive urinary β2 microglobulin to creatinine ratio (β2MG/Cr) data as a possible predictive factor of IVIG therapy resistance. Objectives: To clarify whether urinary β2MG/Cr is an effective predictive factor for IVIG therapy resistance. Methods: We retrospectively reviewed the data of all patients with KD who underwent IVIG therapy at a dose of over 6g/kg in our hospital from January 1997 to January 2014. Patients with recurrent KD were excluded from the study. Patients were divided into two groups for analysis, those who did and did not require PE. Factors including urinary β2MG/Cr were compared across the two groups. We used the peak urinary β2MG/Cr of each patient in the course of the disease. Results: There were 713 patients with KD who were treated in our hospital from January 1997 to January 2014. There were 28 patients without recurrent KD who underwent IVIG therapy over 6g/kg. IVIG was successful in 24 patients (non-PE group), and 4 patients required PE (PE group). Urinary β2MG/Cr was not measured in only one patient of the non-PE group. Urinary β2MG/Cr significantly higher in the PE group (median 119,228 μg/gCr, 69,286-234,290 μg/gCr) compared to the non-PE group (median 12,270 μg/gCr, 1,981-210,647 μg/gCr) (p=0.001, t-test). Urinary β2MG/Cr exceeded 100,000 μg/gCr in 4 % (1 of 23) of the PE group and 75 % (3 of 4) of non-PE group. There were temporarily coronary artery lesions (dilation or aneurysm) in 57 % (13 of 23) of the non-PE group and 75 % (3 of 4) of the PE group. Coronary artery lesions regressed in all patients. Conclusion: Our study suggests that urinary β2MG/Cr measurement is a useful non-invasive test for predicting IVIG resistance.
Self-Assessment Colour Review of Respiratory Medicine
Authors: T Orchard, C Eraut, A Davison, M Doherty, P Spence, D Graham, M Cheetham, X Sun, J Earis, D P S Spence, H Shah, P Mills, J George, J Wedzicha
Journal: Thorax (1998)

The case report is presented of a patient with longstanding cryptogenic fibrosing alveolitis who developed a high grade B cell non-Hodgkin's lymphoma in an area of fibrosis.
Tofu: An Unlikely Cause of Botulism
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical Summaries
Journal: Circulation (2008)

Sudden cardiac death remains a leading cause of mortality despite advances in medical treatment for the prevention of ischemic heart disease and heart failure.Studies of the implantable cardioverter defibrillator (ICD) showed significant reductions in mortality among certain high-risk cohorts of patients.Recently, there has been a dramatic increase in ICD use for primary prevention, largely because of the results of 2 studies: the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT) and the second Multicenter Automatic Defibrillator Implantation Trial (MADIT II).However, both studies showed that shocks for ventricular tachyarrhythmias occurred in only 25% to 35% of subjects during 4 to 5 years of follow-up.This suggests that many ICD patients may not benefit from this invasive therapy and that better risk stratification is needed to optimize patient selection.In this regard, microvolt T-wave alternans (TWA) is a noninvasive test of arrhythmia vulnerability.Previous observational studies showed that TWA predicted ICD shocks or arrhythmic events in diverse patient populations.This has led some to propose using TWA to identify patients most likely to benefit from ICD implantation; however, the value of TWA for risk stratification had not been evaluated previously in a randomized trial of ICD therapy.In the present study, 490 patients enrolled in SCD-HeFT underwent TWA testing and were followed up prospectively.TWA testing did not predict arrhythmic events or mortality in the cohort as a whole or in subgroups with ischemic or nonischemic cardiomyopathy.Accordingly, these results suggest that TWA is not useful as an aid in clinical decision making about ICD therapy among patients with heart failure and left ventricular dysfunction.See p 2022.
"TRACHOMA"
Authors: Anna W. Williams
Journal: JAMA (1926)

<h3>To the Editor:</h3> —The term "trachoma" should still be enclosed in quotation marks. Why? Because the diagnosis (?) is still being made only after the eye conditions to which it is being applied have reached an advanced stage. Royer in his plea for the need of epidemiologic research in "trachoma" (<i>Am. J. Pub. Health</i><b>16</b>:706, 1926) seems not to have been aware of the epidemiologic, etiologic and therapeutic investigations in "trachoma," extending over more than three years, that the Bureau of Laboratories of the New York City Health Department made, beginning in the spring of 1910 and stopping at the end of 1913. These studies were published in the<i>Journal of Infectious Diseases</i>(<b>14</b>:261, 1914) and more fully in the Collected Studies of the Bureau of Laboratories, New York City Health Department, volume VII. In these studies we clearly showed that the reason why opinions differed so much in
Forty Notifiable Diseases. A Simple Discussion of the More Important Communicable Diseases.
Authors: Caspar Hodgson
Journal: JAMA (1922)

Our knowledge of infections and how to prevent them is now so definite and so complete that in this field of hygiene we are able to rest most of our practices on a sure basis of scientific truth.In consequence our victories over these causes of illness have been overwhelming, and with the wider application of our knowledge even more startling results will be secured.Pubhsher and editor have pleasure in offering in Forty Notifiable Diseases a brief compend of important facts concerning communicable diseases that should be a part of the information possessed by every American citizen.The author is an experienced and practical worker who knows exactly where effort should be di- rected to secure a maximum health return.
Kupffer cell activity and hepatic microvascular events after acute ethanol ingestion in mice
Authors: H Eguchi
Journal: Hepatology (1991)

After acute ethanol ingestion in C57B1/6 mice, phagocytic activity of Kupffer cells and hepatic microcirculation were examined by in vivo and electron microscopy. A ratio of Kupffer cells that phagocytosed 0.8 μm fluorescent latex particles to sinusoids containing blood flow (number of Kupffer cells/number of sinusoids containing blood flow) was used as a measure of Kupffer cell phagocytic activity. Three hours after ingestion of 1 gm/kg ethanol, number of Kupffer cells/number of sinusoids containing blood flow increased in both periportal and centrilobular regions by 62% and 66%, respectively, and blood ethanol was no longer detectable. Ultrastructurally, activation of KC was evidenced by the presence of many pseudopodia and filopodia. Numbers of swollen endothelial cells were increased in both regions by 249% and 174%. Interruption of sinusoidal blood flow by leukocytes was aggravated in both regions by 127% and 167%. Thirty minutes and 3 hr after ingestion of 4 gm/kg ethanol, no significant increase in number of Kupffer cells/number of sinusoids containing blood flow was seen, although number of Kupffer cells were also activated as seen with electron microscopy. An increased number of swollen endothelial cells was observed in both regions by 100% and 71% by 30 min and by 200% and 384% by 3 hr. The interruption of sinusoidal blood flow by leukocytes was also increased (periportal = 161%, centrilobular = 196%) as were sticking or plugging leukocytes in sinusoids (periportal = 320%, centrilobular = 120%) by 3 hr. The diameter of centrilobular sinusoids was decreased by 3 hr. Latex particles and platelets were attached to the sinusoidal wall after both low and high dosing. These findings suggest that acute ethanol ingestion activated Kupffer cells and affected the functions of leukocytes, platelets and endothelial cells. (HEPATOLOGY 1991;13:751–757.)
ERRATUM
Journal: BMJ (1854)

Mr. AiczLL sad that the deputation all oncurnd, with ose sight shades of difference, in the objectiono The pro.busies was agreed, with some little exception, on the principles drf orm; and the exception to which he alluded was the oppo.ston offed by the present governing bodies to the repre.eaion of the profession in the CounciL He hoped that the government would take up the matter, and act according to the wants of the profession; and he trusted that no bill would be introduced which did not include the principles of uuiformity of education, reciprocity of practice, and representation in the governing Council, as well as a penal code for the prevention of illegal practice.Dr. MURPny explained the anomalous position in which the graduates of medicine in different parts of the kingdom are placed, through want of reciprocity of practice.Dr. O'CoNNop forcibly exhibited the injustice of Mr. Brady's Bill, rendering many practitioners in medicine, in different parts of the kingdom, obnoxious to prosecution.He had ascer- tained that there are in England 2500 graduates of universities in practice, and only f(66 licentiates or fellows of the College of Physicians in London.In Scotland, there are 560 medical
Erratum: Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes
Authors: D J Smyth, J M M Howson, C E Lowe, N M Walker, A C Lam, S Nutland, J Hutchings, E Tuomilehto-Wolf, J Tuomilehto, C Guja, C Ionescu-Tîrgovişte, D E Undlien, K S Rønningen, D Savage, D B Dunger, R C J Twells, W L McArdle, D P Strachan, J A Todd
Journal: Nature Genetics (2005)
Corrigendum: One-eyed Pilots
Journal: BMJ (1937)

present employment he can either ignore the £50 car allowance or include it, and then deduct the running costs and depreciation of the car, but not instalments of purchase price, as thev are capital outlay.As the assessments for each year wiil presumably be made after the financial year is over, the whole tax for that year will become due a few weeks after the assessment is made.
Interaction of Asbestos with Metaplastic Squamous Epithelium Developing in Organ Cultures of Hamster Trachea
Authors: C. D. Woodworth, B. T. Mossman, J. E. Craighead
Journal: Environmental Health Perspectives (1983)

The normal mucociliary epithelium of the respiratory tract in chronic cigarette smokers often is replaced focally by a metaplastic squamous epithelium. Because asbestos workers who smoke have a substantially greater risk of bronchogenic carcinoma than nonsmokers, we hypothesized that interaction of asbestos with squamous epithelium might be a contributing factor. To address this question, an in vitro model was developed to study the interaction of asbestos with both mucociliary and squamous epithelium. Explants of tracheas from hamsters were cultured in either a chemically defined minimal essential medium, which maintains a differentiated epithelium, or a nutritionally complex medium, which encourages the development of squamous metaplasia. Scanning electron microscopy (SEM) was used to measure quantitatively the development of a squamous epithelial surface on the explants. The interaction of chrysotile and crocidolite asbestos with cells of the mucociliary and squamous epithelium was studied using both SEM and transmission electron microscopy (TEM). Long fibers of asbestos were cleared, whereas shorter fibers were phagocytized by cells of the mucociliary epithelium. In contrast, asbestos was phagocytized by superficial squamous cells regardless of fiber length, and fibers penetrated between intercellular junctions in the metaplastic epithelium. The relevance of these interactions to the induction of bronchogenic carcinoma is discussed.
Headache following subarachnoid puncture. Treatment with epidural blood patch
Authors: P. M. Glass
Journal: JAMA (1972)

After hydration and analgesics had failed to alleviate symptoms in a patient with an incapacitating headache secondary to spinal puncture, the injection of autologous blood into the epidural space afforded prompt and permanent relief. "Patching" the dural hole with autologous blood is the most direct therapy available. This procedure may be considered for patients who continue to experience incapacitating symptoms following a trial of supportive therapy.
Highlights
Journal: JAMA (2016)

Eff ect of Cranberry Capsules on Bacteriuria and Pyuria 1879Proanthocyanidins present in cranberries inhibit adherence of Escherichia coli to uroepithelial cells, which has prompted the investigation of cranberry products as a potential nonantimicrobial strategy to prevent urinary tract infection.In a randomized placebocontrolled clinical trial involving 185 women residing in 21 nursing homes, Juthani-Mehta and colleagues found that compared with placebo capsules, daily administration of oral cranberry capsules (containing proanthocyanidins equivalent to 20 ounces of cranberry juice) for 1 year resulted in no signifi cant diff erence in the presence of bacteriuria plus pyuria.In an Editorial, Nicolle discusses the lack of evidence to support cranberry products for prevention of urinary tract infection.
British Medical Journal, London
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pancreatic endoscopy
Authors: R. Kozarek
Journal: Endoscopy (2008)

Therapeutic pancreatic endoscopy continues to aggressively evolve even as magnetic resonance cholangiopancreatography (MRCP) and endoscopic ultrasonography (EUS) continue to chip away at endoscopic retrograde cholangiopancreatography (ERCP) as a diagnostic modality alone. Thus, the ability of EUS to directly aspirate cystic lesions of the pancreas for cytology, amylase, and carcinoembryonic antigen (CEA), as well as genetic markers, may make diagnostic ERCP superfluous in this setting. Moreover, MRCP can usually demonstrate the communication between a side-branch intraductal papillary mucin-producing neoplasm (IPMN) and the main pancreatic duct. Data are now clear that asymptomatic patients with a lesion consistent with a side-branch IPMN found on another imaging modality, measuring < 3 cm in diameter, and with no mural modularity within the wall, have a negligible risk of malignancy, may require neither ERCP nor EUS, and can be followed by serial imaging studies.
Antibiotic therapy for otitis media with effusion. A response from Pittsburgh
Authors: E. M. Mandel
Journal: JAMA (1993)

CANTEKIN et al<sup>1</sup>have recently challenged our 1987<i>New England Journal of Medicine</i>report<sup>2</sup>that in infants and children with otitis media with effusion (secretory otitis media), amoxicillin treatment modestly increased the likelihood of resolution. From reanalyses of our clinical trial data, Cantekin et al concluded instead that amoxicillin had been no more efficacious than placebo, and that otoscopic diagnoses in our trial had been biased. Further, they cited reports "indicat[ing] that antimicrobial treatment is not effective even for acute otitis media." To arrive at these positions, Cantekin et al committed a series of methodological improprieties, invoked fallacious concepts and invalid assumptions, and inadequately represented the findings of cited studies. Space constraints preclude our discussing these fully, but the most important were the following: <h3>Post Hoc Use of an Altered and Invalid Method for Determining Outcome.</h3> —Our amoxicillin trial was conducted from 1981 through 1984. Its original protocol