tbuckley/cabot-search huggingface dataset:
Literature
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effects of tilting on central hemodynamics and homeostatic mechanisms in cirrhosis
Authors: S�ren M�ller, Annette N�rgaard, Jens H. Henriksen, Erik Frandsen, Flemming Bendtsen
Journal: Hepatology (2004)

Patients with cirrhosis have a hyperdynamic circulation and an abnormal blood volume distribution with central hypovolemia, an activated sympathetic nervous system (SNS) as well as the renin-angiotensin-aldosterone system (RAAS). As the hyperdynamic circulation in cirrhosis may be present only in the supine patient, we studied the humoral and central hemodynamic responses to changes with posture. Twenty-three patients with alcoholic cirrhosis (Child-Turcotte-Pugh classes A/B/C: 2/13/8) and 14 healthy controls were entered. Measurements of central hemodynamics and activation of SNS and RAAS were taken in the supine position, after 30° head-down tilting, and after 60° passive head-up tilting for a maximum of 20 minutes. After the head-up tilting, the central blood volume (CBV) decreased in both groups, but the decrease was significantly smaller in patients than in controls (−19% vs. −36%, P < .01). Central circulation time increased only in the patients (+30% vs. −1%, P < .01). The absolute increases in circulating norepinephrine and renin after head-up tilting were significantly higher in the patients than in the controls (P < .05 and P < .01, respectively). In patients with cirrhosis, changes in SNS and RAAS were related to changes in arterial blood pressure, systemic vascular resistance, heart rate, non-CBV, plasma volume, and arterial compliance. In conclusion, cardiovascular and humoral responses to changes in posture are clearly abnormal in patients with cirrhosis. Head-up tilting decreases the CBV less in patients with cirrhosis, and the results suggest a differential regulation of central hemodynamics in patients with cirrhosis. (Hepatology 2004;40:811–819).
"THE PIRQUET SYSTEM OF NUTRITION AND ITS APPLICABILITY TO AMERICAN CONDITIONS"
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dermatology
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The attitudes of students and house staff toward alcoholism
Journal: JAMA (1990)

<h3>To the Editor.—</h3> David Rivlin won his court case and told reporters: "I'm surprised, I'm not scared. I feel rather peaceful. There's a little bit of fear—the fear of the unknown—but not much" (<i>USA Today</i>. July 21, 1989). Fifteen days later he was dead. The legal decision allowed him to determine the time, place, and manner of his death—sedation followed by termination of the respirator. David was competent, not in a persistent vegetative state, nor was he an advanced case of cardiac failure or dependent on advanced life support. He was not terminally ill and imminently dying. He was quadriplegic and respirator dependent and argued: "I can't see living like this for 20 more years. It could turn a person bitter toward life and toward people, and I don't want that to happen to me" (<i>USA Today</i>. July 7,1989). He said he was tired of being a burden on others
Incorrect Sentence in: Effect of Shock Wave–Facilitated Intracoronary Cell Therapy on LVEF in Patients With Chronic Heart Failure: The CELLWAVE Randomized Clinical Trial
Authors: Israel Agaku, Constantine Vardavas, Olalekan Ayo-Yusuf, Hillel Alpert, Gregory Connolly
Journal: JAMA (2013)

Effect of Shock Wave–Facilitated Intracoronary Cell Therapy on LVEF in Patients With Chronic Heart Failure: The CELLWAVE Randomized Clinical Trial
PERFORATION IN TYPHOID FEVER.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Systolic blood pressure, arterial rigidity, and risk of stroke. The Framingham study
Authors: W. B. Kannel
Journal: JAMA (1981)

Based on prospective data from the Framingham study relating systolic pressure, diastolic pressure, age, and pulse-wave configuration to future stroke incidence, it would appear that isolated systolic hypertension predisposes to stroke independent of arterial rigidity. The prevalence of isolated systolic hypertension increased with age and with the degree of blunting of the dicrotic notch in the pulse wave. Subjects with isolated systolic hypertension experienced two to four times as many strokes as did normotensive persons. While diastolic pressure is related to stroke incidence, in the subject with systolic hypertension, the diastolic component adds little to risk assessment and in men, in this subgroup, appears unrelated to stroke incidence. (<i>JAMA</i>1981;245:1225-1229)
In consultations male doctors communicate like women
Journal: BMJ (1999)

Impaired fertility and testicular cancer share common causes Indicators of male reproductive hazards have reportedly increased in many populations-for example, incidence of testicular cancer, low sperm counts, the dizygotic twinning rate, and the secondary sex ratio.It is unknown whether different indicators tend to occur together in individual men or whether the observed trends (if real) are just coincidental phenomena.On p 559 Møller and Skakkebaek report the results from a population based case-control study in Denmark, which shows a strong association in men between subfertility and subsequent risk of testicular cancer.The authors suggest that these results are consistent with the hypothesis that common causal factors exist that affect both a man's ability to reproduce and his probability of developing testicular cancer. Chinese herbal creams may contain steroidsPatients with eczema often report success with Chinese herbal creams.Keane et al (p 563) decided to analyse the content of creams used by their patients and found that most contained dexamethasone in various concentrations.The preparations were often supplied in unlabelled containers without clear instructions.The authors call for closer regulation of herbal medicines to ensure adequate labelling and to prevent dispensing of unlicensed products in the guise of herbal treatments.
AIDS Exceptionalism
Authors: David Casarett
Journal: Annals of Internal Medicine (1999)

Letters5 January 1999AIDS ExceptionalismDavid Casarett, MD, MA and John Lantos, MDDavid Casarett, MD, MASearch for more papers by this author and John Lantos, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-130-1-199901050-00031 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We are not surprised that Dr. Bolan was annoyed by our article's title, but we deeply regret if he found it flippant or cynical. This was hardly our intent. As physicians in palliative medicine and pediatrics who care for HIV-positive patients, we are sympathetic to his position. However, we disagree with his suggestion that an entitlement is economically necessary to protect an investment. We fear that an entitlement would only widen the gap in access that separates AIDS and other diseases.Dr. Bolan also proposes that an entitlement is ethically necessary. This claim requires additional justification, such as ...Reference1. Bayer R. Public health policy and the AIDS epidemic. An end to HIV exceptionalism? N Engl J Med. 1991;324:1500-4. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoHave We Treated AIDS Too Well? Rationing and the Future of AIDS Exceptionalism David J. Casarett and John D. Lantos AIDS Exceptionalism Robert K. Bolan AIDS Exceptionalism Mary Bessesen , Marianne McCollum , and BCBS AIDS Exceptionalism Richard Frothingham Metrics 5 January 1999Volume 130, Issue 1Page: 80KeywordsAIDSEmotionsFearHIVHIV preventionHealth careHeart diseasesPatientsPediatricsProtease inhibitors Issue Published: 5 January 1999 CopyrightCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Abstract 1263: Midkine Prevents Ventricular Remodeling After Myocardial Infarction Through Enhancement Of Angiogenesis Via PI3k/akt Pathway
Authors: Hiroharu Takenaka, Hisayuki ishiguro, Arihiro Simida, Akihiko Usui, Kenji Kadomatu, Itsuo Kodama, Yuichi Ueda, Misturu Horiba
Journal: Circulation (2007)

Background: Midkine (MK) protein is a heparin-binding growth factor. We reported recently endogenous MK ameliorates not only acute myocardial infarction (MI) but also long-term survival after MI using MK knockout mice (MKKO). We aim to assess the therapeutic potential of MK protein after MI by exogenous application. Method and results: MI was created in C57BL/6 mice (n=29) by ligation of the left coronary artery. In 11/29 mice, human recombinant MK protein was administrated for 28 days by osmotic pump intraperitoneally (MK-T). Saline was administrated in the same manner for control group (Control) (n=18). Survival rate 28 days after MI in MK-T was significantly higher than Control (82% vs. 44%, p&lt;0.05). In echocardiography 28 days after MI, MK-T showed significantly better LV function compared to Control ( LVEDd; 4.3±0.5 vs. 6.0±0.4 mm, LVESd; 3.6±1.0 vs. 5.3±0.4 mm, EF; 44.3±10.1, vs. 32.1±0.6%, FS; 21.2±5.4 vs.15.3±0.3%, P&lt;0.05). The serum BNP levels 28 days after MI in MK-T was significantly lower than that of Control (129 ± 5 pg/dl vs. 370 ± 98 pg/dl, P&lt;0.05). Size of scar volume quantified by fibrosis area (picrosirius red) in MK-T was significantly smaller than Control (30.3 ± 5 vs. 52.3± 5%, p&lt;0.05). The number of CD31-immunopositive cells in peri-infarct area of LV at 28 days in MK-T was significantly higher than those of Control (45.2 ± 5 V.S. 27.3 ± 5, p&lt;0.05). These changes were associated with an activation of Akt phosphorylation (1.61 fold higher than control, p&lt;0.05) in LV tissue. In-vitro experiments using human umbilical vein endothelial cells (HUVEC) with 100 ng/ml MK caused a significant increase of tube formation with enhacement of Akt phosphorylation (1.68 fold higher than control, P&lt;0.05), and this upregulation was reversed completely by wortmannin, a specific inhibitor of PI3K. Conclusion: MK protein prevents the cardiac remodeling after MI and improves the survival through enhancement of angiogenesis via PI3K/Akt pathway. Exogenous application of MK protein might be a new therapeutic strategy for treatment of heart failure.
A phase I study of thalidomide, capecitabine and temozolomide (TCT) in advanced cancer
Authors: C. Salvador, L. Bhupalam, B. Taft, J. Frantz, C. Schonard, V. R. Sharma, F. J. Hendler, D. M. Miller, D. A. Laber
Journal: Journal of Clinical Oncology (2004)

3141 Background: Oral therapy offers the tremendous advantage of independence and avoids all the catheter-related complications. With this novel combination of immune-modulatory and chemotherapeutic agents we explore the possibility of antitumoral synergistic activity in advanced metastatic solid tumors, and at the same time develop an oral palliative regimen that does not require hospitalization or intravenous access. Methods: Patients were enrolled in cohorts of 3. Thalidomide 100 mg was given for one week. If well tolerated, capecitabine and temozolomide (TCT) were started at the appropriate dose level, as described below. All 3 drugs were given p.o. q.hs. every day with no breaks. If no toxicity was observed 28 days (1 cycle) after therapy, the next group was enrolled into the next dose level. Responses were assessed every 2 cycles by using the RECIST guidelines. Results: From August 2003 through December 2003, 9 patients with advanced cancer were enrolled. Prior to TCT treatment, all patients had objective documentation of progressive metastatic disease after multiple therapies. Patient characteristics: male 6, female 3, age 50 (34–70), PS ECOG 1 (0–2). Type of cancer: 3 renal and 1 nasopharyngeal, esophageal, colon, anal, pancreas and bladder. All patients are evaluable for toxicity and 6, who completed at least 2 cycles of TCT, for response. 20 cycles of TCT have been administered (1–6 cycles/patient). 3/6 patients had stable disease (renal, colon and nasopharyngeal), 2 patients progressed after 2 cycles and 1 withdrew from the study for personal reasons before assessment of response. Grade 1 constipation occurred in 5 patients. No other toxicity of any type has been observed. Most of the patients reported to be sleeping better. Further dose escalation to level 4 is ongoing. Conclusions: TCT is a well tolerated oral chemo-immunotherapy combination for the treatment of patients with advanced cancer. No significant financial relationships to disclose.
Short stature. Etiology, diagnosis, and treatment
Authors: B Linder, F Cassorla
Journal: JAMA (1988)

<h3>SELECTED CASE</h3> THE PATIENT is a 12 3/12-year-old Colombian boy with growth hormone deficiency. He was the full-term product of twin gestation and was born by repeated cesarean section, without complication. His birth weight was 2.5 kg and his twin sister's was 2.3 kg. Early growth and development were normal; however, by the end of the first year of life, the patient's growth was lagging behind that of his twin. Workup in Colombia reportedly revealed a parasitic infection. After appropriate treatment, growth velocity increased transiently. By the age of 2 years, however, growth velocity had again declined and by the age of 3 years, the patient was reportedly 10 to 12 cm shorter than his twin sister. The mother is 167 cm tall, the father is 190 cm, and a 14-year-old sister was 172 cm at the time. This child was first seen at the National Institutes of Health, Bethesda,
Psychiatry
Authors: Vernon P. Williams
Journal: New England Journal of Medicine (1947)

THE subject of psychiatry is discussed under the headings of leukotomy, shock therapy, neuropsychiatric disorders in veterans and psychiatric education.LeukotomyDuring the past ten years surgical operations have been done on the frontal areas of the human brain in an attempt to relieve psychotic patients, as well as some patients with neurotic reactions, from symptoms that apparently were to be persistent and had not yielded to less drastic forms of treatment.Egas Moniz,1 in Portugal, was the first surgeon to undertake the operation that is now known as "prefrontal lobotomy," or "leukotomy," a better term in use in England. . . .
Acromegaly.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A FATAL CASE OF ACUTE ARTICULAR RHEUMATISM
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Laboratory Investigation, New York
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Are you susceptible to rubella?
Authors: J. H. McCubbin
Journal: JAMA (1980)

<h3>To the Editor.—</h3> Physicians and nurses who practice obstetrics may be unknowingly susceptible to rubella. Their acquisition of the disease potentially endangers a large number of fetuses. There has been a recent report of classic rubella illness in an actively practicing obstetrician.<sup>1</sup>This problem can be prevented. Each member of an obstetrical team (attending, house staff, students, nurses) could be tested for rubella immunity. Commercial tests are readily available. Assessment of immune status is rapid, inexpensive, and accurate. The test principle is simple. Rubella virus has the property of agglutinating RBCs. Rubellaspecific antibodies will inhibit this agglutination. Any seronegative member of the obstetrical team could be immunized for rubella. A past history of rubella illness should not be accepted as an indication of immunity. Only serological testing is adequate proof of immunity. It seems prudent to be aware of this potential problem and to actively take steps toward prevention.