tbuckley/cabot-search huggingface dataset:
Book Listings
Journal: Annals of Internal Medicine (2001)

Book Listings19 June 2001Book ListingsSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-134-12-200106190-00001 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Alternative MedicineAcupuncture: Efficacy, Safety and PracticeBritish Medical Association. 131 pages. Newark, NJ: Gordon and Breach/Harwood Academic; 2000. $24.00. ISBN 905823164X. Order phone 800-545-8398.Fundamentals of Complementary and Alternative Medicine2nd edition. MS Micozzi, ed. 464 pages. Philadelphia: WB Saunders; 2001. $49.00. ISBN 0443065764. Order phone 215-238-7800.Handbook of Religion and HealthHG Koenig, ME McCullough, and DB Larson. 712 pages. New York: Oxford Univ Pr; 2001. $65.00. ISBN 0195118669. Order phone 800-451-7556.Integrative Health Care: Complementary and Alternative Therapies for the Whole PersonVS Sierpina, ed. 396 pages. Philadelphia: FA Davis; 2001. $30.00. ISBN 0803607040. Order phone 800-323-3555.CardiologyAtherosclerosis: Gene Expression, ... Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 19 June 2001Volume 134, Issue 12Page: B1KeywordsBurnsComputed axial tomography ePublished: 19 June 2001 Issue Published: 19 June 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
AVOIDABLE RAILROAD ACCIDENTS.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Direct-current countershock without anesthesia. Experience in a military hospital in the management of arrhythmias
Authors: A. B. Farfel
Journal: JAMA (1967)

IN 1962, Lown, Amarasingham, and Neuman<sup>1</sup>introduced synchronized direct-current capacitance discharge in the management of cardiac arrhythmias. The efficacy of cardioversion has been clearly demonstrated. An initial limitation of the method was the requirement of general anesthesia. Stock<sup>2</sup>first suggested that in view of the brief duration of the shock (2.5 msec), cardioversion could be done safely without undue discomfort in the absence of anesthesia. The purpose of this communication is to present experience with electrical countershock, at the US Army General Hospital, Landstuhl, Germany, between May 1965 and May 1966, and in particular, its use without anesthesia. <h3>Methods</h3> The Lown "Cardioverter"<sup>3</sup>was used. Patients were selected for elective conversion only if clinical evaluation suggested it would be beneficial and there was a good probability of maintaining sinus rhythm once reverted. Each patient had had at least one previous attempt at reversion by pharmacological means. Treatment with
Abstract 3157: Coupling of Left Ventricular Relaxation to Systolic Contraction in Normal, Hypertrophied, and Dilated Myocardium Quantified by Speckle-Tracking Global Strain and Strain Rate Imaging
Authors: Takeshi Takamura, Kaoru Dohi, Katsuya Onishi, Naoki Fujimoto, Tairo Kurita, Shinya Kato, Takashi Tanigawa, Norikazu Yamada, Naoki Isaka, Masaaki Ito
Journal: Circulation (2007)

Background: It has not been fully investigated whether impairments of left ventricular (LV) relaxation precede or couple to systolic dysfunction during the disease process ranged from latent myocardial dysfunction to failing myocardium in patients with either left ventricular hypertrophy (LVH) or dilated cardiomyopathy (DCM). Methods: To quantify global LV longitudinal (L) and circumferential (C) function, fifty-seven patients with hypertensive LVH (ejection fraction 58 ± 10 %), twenty-one patients with DCM (ejection fraction 33 ± 13 %), and fifty-seven normal controls (Controls: ejection fraction 65 ± 6 %) had echo-study with speckle-tracking strain and strain rate imaging (Vivid 7 and EchoPAC, GE Electronic) from apical 4-, 2-, long axis, and mid-ventricular short axis views. Global peak systolic strain (PSS) and peak relaxation rate (PRR) were used as indices of global LV contraction and relaxation, respectively. Results: PRR was significantly correlated to PSS from both (L) and (C) in LVH, DCM, and Controls with linear regressions, respectively (DCM (L); r = 0.81 * , (C); r = 0.81 * , LVH (L); r = 0.78 * , (C); r = 0.74 * , Control (L); r = 0.64 * , (C); r = 0.70 * , * p &lt; 0.05). Furthermore, correlations between PSS and PRR were best fit with exponential regression from (L) and linear regression from (C) all through the subjects ((L); y = 0.18e -0.099x , r = 0.84 * , (C); y = −0.070x - 0.017, r = 0.79 * , * p &lt; 0.05). Conclusion: Speckle-tracking strain and strain rate imaging exhibited the strong coupling of LV relaxation to systolic contraction ranged from the normal to failing myocardium regardless of their initiating disease process.
120. Efficient In Vivo Liver-Directed Gene Editing Using CRISPR/Cas9
Authors: Kshitiz Singh, Hanneke Evens, Melvin Rincón, Nisha Nair, Shilpita Sarcar, Ermira Samara-Kuko, Marinee K. Chuah, Thierry VandenDriessche
Journal: Molecular Therapy (2016)

Clustered, regularly interspersed, short palindromic repeat RNA-guided nucleases have emerged as highly efficient genome editing tools. However, in vivo tissue-specific genome editing at the desired loci is still a challenge. Here, we report that truncated guide RNAs (gRNAs) and Cas9 under the control of a computationally designed hepatocyte-specific promoter lead to liver-specific and target site-specific indel formation in the mouse factor IX (FIX) gene. The truncated gRNAs targeting unique sites in exon 1 and exon 6 of the mouse FIX gene were designed using a computational CRISPR design tool and the target sites overlap with mutations known to cause hemophilia B in patients. The gRNA and Cas9-expressing constructs were delivered in vivo using AAV9 vectors. The efficiency of in vivo targeting was assessed by T7E1 assays, site-specific Sanger sequencing and deep sequencing of on-target and putative off-target sites. Though AAV9 transduction was apparent in multiple tissues and organs, Cas9 expression was restricted mainly to the liver, with only minimal or no expression in other non-hepatic tissues. Consequently, the indel frequency was robust in the liver (up to 50%) in the desired target locus of the FIX gene, with no evidence of targeting in other organs. This resulted in a substantial loss of FIX activity and the emergence of a bleeding phenotype, consistent with hemophilia B. Deep sequencing of putative off-target sites revealed no off-target editing. Our findings have potentially broad implications for somatic gene editing in the liver using the CRISPR/Cas9 platform.
Salt and hypertension
Authors: B. H. Scribner
Journal: JAMA (1983)

The controversy over whether the habitual level of sodium chloride intake has any causal relationship to hypertension has continued since the pioneering work of Ambard and Beaujard<sup>1</sup>and Allen.<sup>2</sup>At the turn of the century, Ambard and Beaujard were among the first to point an accusing finger at high salt intake as a major factor in the pathogenesis of essential hypertension. The article by Holden et al in this issue (p 365) represents a novel approach to the problem of trying to correlate habitual salt intake with BP in a large population. Their negative results agree well with those of numerous previous studies of other large population groups.<sup>3,4</sup> Meneely and Battarbee<sup>5</sup>explained why all such studies fail to reveal the true relationship between sodium intake and essential hypertension. Meneely and Battarbee have termed it "the saturation effect." What that means requires some explanation, which I have
THE SURGICAL TREATMENT OF BRAIN ABSCESS
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical Lectures on the Diagnosis of Carcinoma of the Breast in its Early Stages: (Delivered at St. George's Hospital.)
Authors: A. M. Sheild
Journal: BMJ (1896)

THE BREAST.CYSTS of the breast closely simulate scirrhous cancer when they are small, tense, single, with thick walls, and deeply seated in the mammary tissue.Large cysts, or cysts asso- .ciatedwith adenomata or sarcomata, should not give rise to -difficulty.In most of these there is a discharge from the nipple, and a sense of elasticity can always be elicited.It is not the object of this paper to deal with the pathology of -cysts of the breasts.They form in a variety of ways, and may be found in women of any age.They are peculiarly common in cases of chronic mastitis and in elderly women.No doubt they then originated in duct obstruction.When you lay your xfingers flat upon the part, and feel a hard swelling deep be- ueath, it is most difficult for you to appreciate or believe that such a swelling may be a tense thick-walled cyst, containing a little honey-coloured fluid.Cancer is usually single '7 Revsv de C 1irirgi",1887 p. 553,
Children and parasuicide.
Journal: BMJ (1981)

Twenty years ago Canetti observed that "drug resistance is a function of the quality of chemotherapy which can be applied . . . it is a problem of drug activity and drug acceptability.For many nations it is also a problem of cost."15The same is true today.Pyle MM.Relative numbers of resistant tubercle bacilli in sputa of patients before and during treatment with streptomycin.
Hematology-Oncology Examination
Journal: JNCI Journal of the National Cancer Institute (1973)

Journal Article Hematology-Oncology Examination Get access JNCI: Journal of the National Cancer Institute, Volume 51, Issue 4, October 1973, Page 1397, https://doi.org/10.1093/jnci/51.4.1397-c Published: 01 October 1973
Error in Group Information
Authors: Ravi Retnakaran
Journal: JAMA Pediatrics (2018)

Matthew W. Harer, MD; David J. Askenazi, MD, MSPH; Louis J. Boohaker, MPH; J. Bryan Carmody, MD, MPH; Russell L. Griffin, PhD; Ronnie Guillet, MD, PhD; David T. Selewski, MD; Jonathan R. Swanson, MD, MSc; Jennifer R. Charlton, MD, MSc; for the Neonatal Kidney Collaborative (NKC)
The Role of Reactive Oxygen and Nitrogen Species in the Response of Airway Epithelium to Particulates
Authors: Linda D. Martin, Thomas M. Krunkosky, Janice A. Dye, Bernard M. Fischer, Nan Fei Jiang, Lori G. Rochelle, Nancy J. Akley, Kevin L. Dreher, Kenneth B. Adler
Journal: Environmental Health Perspectives (1997)

Epidemiologic and occupational studies indicate adverse health effects due to inhalation of particulate air pollutants, but precise biologic mechanisms responsible have yet to be fully established.The tracheobronchial epithelium forms the body's first physiologic barrier to such airborne pollutants, where ciliary movement functions to remove the offending substances caught in the overlying mucus layer.Resident and infiltrating phagocytic cells also function in this removal process.In this paper, we examine the role of reactive oxygen and nitrogen species (ROS/RNS) in the response of airway epithelium to particulates.Some particulates themselves can generate ROS, as can the epithelial cells, in response to appropriate stimulation.In addition, resident macrophages in the airways and the alveolar spaces can release ROS/RNS after phagocytosis of inhaled particles.These macrophages also release large amounts of tumor necrosis factor alpha (TNF-a), a cytokine that can generate responses within the airway epithelium dependent upon intracellular generation of ROS/RNS.As a result, signal transduction pathways are set in motion that may contribute to inflammation and other pathobiology in the airway.Such effects include increased expression of intercellular adhesion molecule 1, interleukin-6, cytosolic and inducible nitric oxide synthase, manganese superoxide dismutase, cytosolic phospholipase A2, and hypersecretion of mucus.Ultimately, ROS/RNS may play a role in the global response of the airway epithelium to particulate pollutants via activation of kinases and transcription factors common to many response genes.Thus, defense mechanisms involved in responding to offending particulates may result in a complex cascade of events that can contribute to airway pathology.
PHYSICIANS' AND SURGEONS' INSTRUMENTS ARE MECHANICAL IMPLEMENTS.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PROPHYLAXIS OF BALDNESS.
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Toxicology
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Exophthalmos
Authors: D. P. Choyce
Journal: BMJ (1955)

<h3>Abstract</h3> Tendons transmit mechanical forces between muscle and bone, and their biomechanical function requires high tensile strength, which is provided by highly organized collagen fibers. Tenocytes mainly drive tendon growth via extracellular matrix (ECM) production and organization. The biological mechanisms regulating tenocyte differentiation and morphological maturation have not been well established, partly due to the lack of a reliable <i>in vitro</i> system. Recent scaffold-free, cell-based tissue engineering approaches developed several unique <i>in vitro</i> tendon-like constructs. However, the application of these constructs is limited to the study of embryonic tendon development due to high cell density and immature matrix organization. In this study, we developed a scaffold-free, three-dimensional (3D) tendon culture system using mouse tendon cells and a differentially adherent growth channel. The 3D tendon constructs exhibited tissue maturation similar to the postnatal mouse tendon, including decreased cell density, increased thickness, and elongated cells between highly aligned extracellular matrix. The 3D tendon culture system is also feasible for genetic manipulation using adenovirus. Overall, the results suggest that the 3D tendon culture system using mouse tendon cells is a reliable <i>in vitro</i> system to study underlying biological mechanisms that regulate cellular and matrix maturation in postnatal tendon development.
Which Dream Does the Patient Tell?
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Rapidly progressive pulmonary infiltrates in chronic myelogenous leukemia
Authors: D. A. Taryle
Journal: JAMA (1979)

ALTHOUGH infection is the most common cause of pulmonary infiltrates in patients with leukemia,<sup>1</sup>other diagnostic considerations include drug-induced disease, hemorrhage, infarction, leukoagglutinin reaction, congestive heart failure, and the leukemic process itself.<sup>2</sup>It is unusual for leukemic infiltration to be a major clinical problem, although pathologically it occurs relatively frequently.<sup>3</sup> <h3>Report of a Case</h3> A 35-year-old woman was admitted to the hospital on Nov 5, 1976, with fever and cough. Philadelphia chromosome-positive chronic myelogenous leukemia had been diagnosed in 1974 following a year of purpura. The patient had received intermittently busulfan, 4 to 8 mg/day for one year, at which time thioguanine was added. In January 1976 Bacillus Calmette-Guérin immunotherapy was instituted. Five months later, pleuropericarditis of unknown origin developed, and isoniazid therapy was given. In July 1976 early myeloblast transformation occurred. Demecolcine, thioguanine, prednisone, and vinblastine sulfate were given, and a splenectomy was performed. No further busulfan
Mikro-Methoden: Zur Kennzeichnung organischer Stoffe und Stoffgemische
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal