tbuckley/cabot-search huggingface dataset:
Mini-microabscess syndrome in liver transplant recipients
Authors: G MacDonald
Journal: Hepatology (1997)

Cytomegalovirus (CMV) is a significant cause of morbidity in immunosuppressed patients. It is characterized in the liver by parenchymal microabscesses, usually containing CMV-infected cells. However, not all hepatic microabscesses are due to CMV infection. In 1992, we described “mini” microabscess (MMA) syndrome, a distinct clinical syndrome that occurs in transplanted livers. This report analyzes the clinical and laboratory features of 57 cases of MMA syndrome occurring in 52 patients and compares these with 19 biopsy-proven cases of CMV infection. The diagnosis of MMA syndrome can only be made histologically. The microabscesses are smaller and more numerous than in CMV infection, and there are no viral inclusions present. CMV DNA could not be detected in liver biopsy specimens with MMAs by using “nested” polymerase chain reaction (PCR), indicating that MMA syndrome is not caused by CMV infection. The pattern of liver enzyme and bilirubin elevation is predominantly hepatocellular, with transaminase levels elevated, on average, six to eight times the upper limit of normal. The clinical features of MMA syndrome are that it predominantly affects female (40 of 52 patients) orthotopic liver transplant (OLT) recipients of all ages (range, 11 months to 66.9 years). MMA syndrome is unrelated to the indication for initial OLT and tends to occur later after transplantation than CMV infection (median, 91 days post-OLT vs. 32 days for CMV hepatitis). Although the etiology of MMA syndrome is not clear, it does not appear to adversely affect graft or patient survival.
$500,000 Hyperbaric Chamber Will Be Erected in Minneapolis
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
GPs management decisions are influenced by patients' social problems in 17% of consultations
Journal: BMJ (1998)

Severely addicted heroin users benefit from heroin maintenance programmeHeroin maintenance is a controversial approach to the rehabilitation of opiate addicts.Researchers from Geneva randomised 51 severely addicted subjects to either immediate or delayed entry into a heroin maintenance programme (controls were given other treatments, mostly methadone maintenance) (p 13).Most experimental patients completed 6 months in the programme, taking about 0.5 g heroin a day intravenously.At follow up the experimental group reported better mental health and social functioning, less crime, and a sharp reduction in consumption of street heroin.But they fared no better than controls in work, commercial sex, and use of street drugs other than opiates.Surprisingly, only a minority of control subjects wanted to enter the heroin maintenance programme at the end of the study.The authors conclude that heroin maintenance is effective as a second line treatment for opiate addiction.
BOOK REVIEW
Authors: E. J. SEIFTER
Journal: JNCI Journal of the National Cancer Institute (1995)

BOOK REVIEW Get access Clinical Oncology , Martin D. Abeloff , James O. Armitage , Allen S. Lichter , John E. Niederhuber , eds. New York : Churchill Livingstone Inc. , 1995 . 2350 pp., illus. $199. ISBN 0-443-08941-8 ERIC J. SEIFTER, M.D., F.A.C.P. ERIC J. SEIFTER, M.D., F.A.C.P. Johns Hopkins Oncology CenterBaltimore, MD 21205 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 87, Issue 16, 16 August 1995, Page 1261, https://doi.org/10.1093/jnci/87.16.1261 Published: 16 August 1995
Response: Re: Tandem vs Single Autologous Hematopoietic Cell Transplantation for the Treatment of Multiple Myeloma: A Systematic Review and Meta-analysis
Authors: A. Kumar, M. Kharfan-Dabaja, B. Djulbegovic
Journal: JNCI Journal of the National Cancer Institute (2009)

ResponseDr Mehta's critique reflects several methodological errors that are commonly raised by clinicians and non-statisticians who review meta-analyses.The first error reflects a substitution of dichotomous data analysis for time-dependent analysis.The dichotomous data analysis is based only on the number of events (summarized as odds or risk ratio) ( 1 ), but the time-dependent analysis also takes into account the duration to a given event and "censoring," which is best summarized as hazard ratios ( 2 ).Therefore, it is incorrect to use timeindependent analyses, as reported by Dr Mehta, when the key outcome is time dependent.Furthermore, Dr Mehta refers to a shift in the overall survival point estimate to justify the use of tandem transplant.
Absence of Hyperactivity in Lead-Exposed Developing Rats
Authors: Dwight Krehbiel, Gary A. Davis, L. Michael LeRoy, Robert E. Bowman
Journal: Environmental Health Perspectives (1976)

It has been reported that postnatal lead treatment produces hyperactivity in rodents. Using rats, we attempted to extend these findings. Locomotor activity of offspring of lead-intubated and pair-fed control mothers was measured at 24-27 days of age, and no significant differences in reactivity or basal activity were found. Observational scoring of the animals at 28-29 and 35-36 days of age indicated that active behaviors were slightly reduced in the lead-treated rats. The brain lead concentrations of experimental animals were slightly reduced in the lead-treated rats. The brain lead concentrations of experimental animals were significantly elevated over controls. Estimates of statistical power indicated that behavioral effects of the magnitude reported in the literature would likely have been detected. The present results indicate that low-level lead exposure may not reliably produce hyperactivity in rodents. A review of the literature suggests that other data provide little support for a recently proposed rodent model of hyperactivity in children.
Medical Paris of To - Day: Notes Made in December, 1888
Authors: E. Hart
Journal: BMJ (1889)

THE Hospice de Bicetre or Hospice des Vieillards et Incurables (men) comprises various categories of wards; some are devoted to cases of mental alienation, epilepsy, or idiotcy; others to the sur- gical and medical affections of old men.Nowhere except in Paris, and there only at the Salpgtri6re, have I found any service comparable with this for its richness in illustration of affections of the nervous system.I shall speak for the moment only of the medical wards under the charge of Dr. Dejerine.They afford a mass of material which furnish the ele- ments in the hands of this accomplished physician for a highly
The Cover
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Athletic injuries.
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Carcinoma of the Cecum Associated With Intussusception
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Zollinger-Ellison Syndrome: Investigators Debate the Origin of Pancreatic Tumors
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
IS CHRONIC NEPHRITIS A PROGRESSIVE DISEASE?
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Kinetics of Alkali-Denaturation of Hemoglobin in Single Erythrocytes
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Judging Medicine
Authors: William P. Deiss
Journal: JAMA (1989)

This volume is a collection of essays on a variety of subjects involving medical, ethical, and legal issues. They have been published in the<i>Hastings Center Report</i>, the authoritative bioethics periodical, during the past decade. The author is a lawyer well known in the area of medical law. He has attempted to arrange the essays into subject areas like patient rights, conception, pregnancy and birth, reproductive liberty (abortion), medical practice, mental retardation and incompetence, death and dying, governmental regulations, and transplants-implants. There is a fair amount of redundancy in this format, so that the same legal case is described more often than one would like. While the essays were of course current when originally published and frequently involved ethical, medical, and legal cases in the news at the time, they have lost a bit of that freshness now. The author's effort to update the legal history of some of the
Contribution of noninvasive evaluation to the diagnosis of pulmonary embolism in hospitalized patients
Authors: M.-J. Miron, A Perrier, H. Bounameaux, P. de Moerloose, D.o Slosman, D Didier, A Junod
Journal: European Respiratory Journal (1999)

The clinical and immunoregulatory effects of long-term macrolide antibiotic therapy for patients with chronic lower respiratory tract infections (CLRTI) were investigated. Clinical parameters and neutrophil chemotactic mediators in the epithelial lining fluid (ELF) of CLRTI patients (n = 10) were examined before and after 3 months oral administration of roxithromycin (RXM). The in vitro effects of RXM were also examined on the release of these mediators from alveolar macrophages (AM) and neutrophils. Arterial oxygen tension (p&lt;0.05), vital capacity (VC) (p&lt;0.001), %VC (p&lt;0.05) and forced expiratory volume in one second (p&lt;0.01) were improved after RXM treatment, but airway bacteria were not eradicated. Among the mediators, the levels of interleukin (IL)-8, neutrophil elastase (NE) and leukotriene B4 (LTB4) were higher in ELF than in plasma of CLRTI patients and they decreased after RXM treatment (n = 7, p&lt;0.05 for each). RXM concentrations were significantly increased in the bronchoalveolar lavage cells of the treated patients. In in vitro experiments, RXM showed inhibitory effects on IL-8 release from AM and neutrophils. In conclusion, interleukin-8, neutrophil elastase and leukotriene B4 contribute to the neutrophilic inflammation in the airways of chronic lower respiratory tract infection patients and the clinical effects of roxithromycin may, in part, be attributable to the suppression of excess release of the chemotactic mediators from inflammatory cells.
Presentation of atrial septal defect in infancy
Authors: W. H. Toews
Journal: JAMA (1975)

Four patients with atrial septal defects and congestive heart failure in the first year of life had none of the classic auscultatory findings of atrial septal defect. Three of four had murmurs suggestive of innocent pulmonaryartery branch stenosis. (<i>JAMA</i>234:1250-1251, 1975)
BUDAPEST
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cardiac Toxicity of Aerosol Propellants
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
HIV transmission through donor artificial insemination
Authors: M. R. Araneta
Journal: JAMA (1995)

<h3>Objective.</h3> —To investigate and report cases of human immunodeficiency virus (HIV) transmission through donor artificial insemination (Al) before 1986 at five infertility clinics. <h3>Design.</h3> —Two types of look-back studies were performed: (1) identification of an HIV-infected woman who reported previous Al, followed by identification of the infected donor(s) and contact tracing of women who were inseminated with his semen, and (2) identification of an HIV-infected donor and subsequent examination of women receiving AI procedures using his semen. <h3>Setting.</h3> —Five infertility clinics in Los Angeles County, California; San Diego County, California; Arizona; and Vancouver, British Columbia. <h3>Patients.</h3> —A total of 230 women were inseminated with semen from any one of the five identified HIV-infected donors; 199 (87%) consented to HIV testing. <h3>Main Outcome Measure.</h3> —Seropositivity for HIV among Al recipients. <h3>Results.</h3> —Seven (3.52%) of the 199 women (95% confidence interval, 1.55% to 7.41% who were artificially inseminated with semen from any of five HIV-infected donors and consented to HIV testing tested HIV-seropositive. Information on HIV risk was available for three of the five donors; all three reported a history of having sex with men. Four HIV-infected women were identified through uncommon circumstances, rather than through routine look-back studies of donors. <h3>Conclusion.</h3> —Infection with HIV through donor Al performed before routine HIV screening of semen donors represents a potentially serious threat to women who underwent Al procedures. Public health policies requiring retrospective identification of HIV-infected semen donors and patients receiving Al before 1986, especially in acquired immunodeficiency syndrome (AIDS)—prevalent areas, should be considered routine. Women diagnosed with AIDS or HIV infection, in whom no identified risk of HIV acquisition is established, should be questioned about previous Al procedures. (<i>JAMA</i>. 1995;273:854-858)