tbuckley/cabot-search huggingface dataset:
Correction: Gene Signatures Associated with Mouse Postnatal Hindbrain Neural Stem Cells and Medulloblastoma Cancer Stem Cells Identify Novel Molecular Mediators and Predict Human Medulloblastoma Molecular Classification
Authors: Daniela Corno, Mauro Pala, Manuela Cominelli, Barbara Cipelletti, Ketty Leto, Laura Croci, Valeria Barili, Federico Brandalise, Raffaella Melzi, Alessandra Gregorio, Lucia Sergi, Salvatore Letterio, Lorenzo Piemonti, Alessandro Bulfone, Paola Rossi, Ferdinando Rossi, Gian Giacomo Consalez, Pietro Poliani, Rossella Galli
Journal: Cancer Discovery (2012)

Medulloblastoma (MB) arises from mutations occurring in stem/progenitor cells located in restricted hindbrain territories.Here we report that the postnatal ventricular zone lining the IV ventricle (IVv) also harbors bona fide stem cells that, remarkably, share the same molecular profile with cerebellar white matter-derived NSCs.To identify novel molecular mediators involved in medulloblastomagenesis, we compared these distinct postnatal hindbrain-derived neural stem cell (NSC) populations, which are potentially tumor-initiating, with compound Ptch/p53 mutant MB cancer stem cells (CSCs) that in vivo faithfully phenotype the different variant of human MB.Transcriptome analysis of both hindbrain NSCs and MB CSCs resulted in the generation of well-defined gene signatures, each reminding of a specific human MB molecular subclass.Most interestingly, MB CSCs upregulated developmentally related genes, such as Ebfs, which we show to be highly expressed in human MBs and to play a pivotal role in experimental medulloblastomagenesis.These data indicate that gene expression analysis holds great promise not only for understanding functional differences between distinct CSC populations but also for identifying meaningful signatures that stratify patients beyond histopathological staging. SignificanceAs the current management of MB is considered unsatisfactory, the functional and molecular comparison between the cell progenitor lineages from which MB is thought to arise and MB cancer stem cells, i.e. the cells responsible for tumor initiation, progression and relapse, might lead to the identification of novel potentially relevant mediators of medulloblastomagenesis.Our findings provide a rationale for the exploitation of mouse CSCs as a valuable preclinical model for human MB, both for the definition of CSC-associated gene signatures holding a highly predictive value when tested across human data sets and for the identification of genes to be targeted therapeutically.
PARIS LETTER.
Authors: None A. B.
Journal: JAMA (1883)

Paris, Nov. 30, 1883. After having been closed for three months, the portals of the Paris Faculty of Medicine were re-opened for the winter session on the 3d inst. I subjoin a list of the professors, with the subjects they are to lecture on, in order to familiarize your readers with the names of some of the leading men of the profession in this country: Prof. Gavarret, Medical Physics; Prof. Peter, Medical Pathology; Prof. Sappey, Anatomy; Prof. Wurtz, Medical Chemistry; Prof. Duplay, Surgical Pathology; Prof. Le Fort, Operative Surgery; Prof. Robin, Histology; Prof. Cornil, Morbid Anatomy; Prof. Laboulbenè, History of Medicine and Surgery; Prof. Brouardel, Medical Jurisprudence; Prof. Germain See, Clinical Medicine at the Hotel Dieu; Prof. Hardy, Clinical Medicine at La Charité; Prof. Potain, Clinical Medicine at Hopital Necker; Prof. Jaccoud, Clinical Medicine at La Pitié; Prof. Ball, Clinical Pathology of Mental Diseases at the Sainte-Anne Asylum; Prof. Fournier,
Obstetric care may be associated with subsequent suicides
Journal: BMJ (1998)

Nut consumption may protect against heart diseaseAlthough nuts are high in fat, the fatty acids are mostly monosaturated or polyunsaturated, which have beneficial effects on blood lipids.In a large prospective study of women, Hu et al (p 1341) found an inverse association between nut consumption and incidence of coronary heart disease.Women who frequently consumed nuts (>5 times per week) had a significantly lower risk of non-fatal myocardial infarction and fatal coronary disease after accounting for age, smoking, and other known coronary risk factors than women who rarely (never or less than once a month) ate nuts.
Infant Mortality Key: 'Pre-Pregnancy Plans'
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hepatic haemodynamic changes induced by severe toxic liver injury . Institute of Liver Studies, King's College School of Medicine and Dentistry, London SE5 9PJ, UK
Journal: Hepatology (1995)

The endothelins (ET) peptide family consists of ET-1, ET-2, ET-3, and sarafotoxin (s6C, a snake venom) and their actions appears to be different among isoforms. The aim of this study was to compare the secretagogue effect of ET-1 on atrial natriuretic peptide (ANP) secretion with ET-3 and evaluate its physiological meaning. Isolated nonbeating atria from male Sprague-Dawley rats were used to evaluate stretch-activated ANP secretion in response to ET-1, ET-2, ET-3, and s6C. Changes in mean blood pressure (MAP) were measured during acute injection of ET-1 and ET-3 with and without natriuretic peptide receptor-A antagonist (A71915) in anesthetized rats. Changes in atrial volume induced by increased atrial pressure from o to 1, 2, 4, or 6 cm H2O caused proportional increases in mechanically-stimulated extracellular fluid (ECF) translocation and stretch-activated ANP secretion. ET-1 (10 nM) augmented basal and stretch-activated ANP secretion in terms of ECF translocation, which was blocked by the pretreatment with ETA receptor antagonist (BQ123, 1 μM) but not by ETB receptor antagonist (BQ788, 1 μM). ETA receptor antagonist itself suppressed stretch-activated ANP secretion. As compared to ET-1- induced ANP secretion (3.2-fold by 10 nM), the secretagogue effects of ANP secretion by ET-2 was similar (2.8-fold by 10 nM) and ET-3 and s6C were less potent (1.7-fold and 1.5-fold by 100 nM, respectively). Acute injection of ET-1 or ET-3 increased mean blood pressure (MAP), which was augmented in the presence of natriuretic peptide receptor-A antagonist. Therefore, we suggest that the order of secretagogue effect of ET family on ANP secretion was ET-1 ≥ ET-2 >> ET-3 > s6C and ET-1-induced ANP secretion negatively regulates the pressor effect of ET-1.
Statistics for medical students.
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Serum haptoglobin. A valuable diagnostic aid in suspected hemolytic transfusion reactions
Authors: D. J. Fink
Journal: JAMA (1967)

A study of a large group of patients was undertaken to determine the effect of compatible whole blood transfusion on the level of serum haptoglobin in order to assess the usefulness of this measurement as a diagnostic test of hemolytic transfusion reactions. In the entire series of 185 patients there were only four cases in which the pretransfusion level was within normal limits and the posttransfusion level was less than 30 mg/100 ml. In all four cases, clinical information is available which adequately explains the drop in serum haptoglobin level. In the only three instances of hemolytic transfusion reactions in the San Francisco area that are known to the authors, the serum haptoglobin determined immediately after the reaction was zero. It is concluded that the measurement of serum haptoglobin is a valuable diagnostic aid in suspected hemolytic transfusion reaction and should be a routine part of the evaluation in all such cases.
BOOK REVIEWS
Authors: G. RAMIREZ
Journal: JNCI Journal of the National Cancer Institute (1993)

BOOK REVIEWS Get access Gastrointestinal Oncology , James D. Ahlgren , John S. Macdonald , eds . Philadelphia : J. B. Lippincott , 1992 . 659 pp., illus. $95. ISBN 0-397-51150-7 GUILLERMO RAMÍREZ, M.D., F.A.C.P. GUILLERMO RAMÍREZ, M.D., F.A.C.P. Human Oncology Department, University of Wisconsin Comprehensive, Cancer Center600 Highland Ave. Madison, WI 53792 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 85, Issue 1, 6 January 1993, Page 64, https://doi.org/10.1093/jnci/85.1.64 Published: 06 January 1993
MEETING OF THE AMERICAN SURGICAL ASSOCIATION.
Journal: JAMA (1897)

The last meeting of the American Surgical Association was notable for the large attendance, the number of scientific papers read and the interest manifested in their discussion. The president, Dr. J.Collins Warren, selected as the subject of his address, " The Influence of Anesthesia on the Surgery of the Nineteenth Century," in which he gave a short history of anesthesia and showed its influence in broadening the field of operative surgery. In his paper on "The Indications for and the Technique of Hysterectomy," Dr.Homanslaid down clear and reliable rules which should govern the surgeon in the selection of cases, and gave sound advice by what route and by what method the uterus should be removed for different pathologic conditions. The paper was ably discussed by Drs.Van der Veer, MuddandLange. Dr. J. W.White'spaper on " The X Ray in Surgery " was profusely illustrated by skiagraphs
THE SIGNIFICANCE OF MORTALITY STATISTICS
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Book Review A Method of Anatomy, Descriptive and Deductive . By J. C. Boileau Grant, M.C., M.B., Ch.B., F.R.C.S. (Edin.). Second edition. 4°, cloth, 794 pp., with 651 illustrations. Baltimore: Williams &amp; Wilkins Company, 1940. $6.00.
Journal: New England Journal of Medicine (1941)
THE SAN FRANCISCO PLAGUE CASES.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Needle Exchange
Authors: Mike Mitka
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Critical timing of -arginine treatment in post-ischemic myocardial apoptosis?role of NOS isoforms
Authors: F LIANG
Journal: Cardiovascular Research (2004)

Background: The role of nitric oxide (NO) in apoptotic cell death has been extensively studied in recent years. However, reported results are inconsistent and often controversial, and the mechanisms underlying its diverse effects in apoptosis regulation remain unidentified. The present study attempted to determine whether in vivo administration of l-arginine, the substrate for NOS, at different time points during the course of myocardial ischemia and reperfusion may differentially regulate post-ischemic myocardial apoptosis, and if so, to investigate the mechanisms involved. Methods and results: Male adult rats were subjected to 30 min of myocardial ischemia followed by 5 h of reperfusion. l-Arginine was administered as a bolus at either 10 min before (early treatment) or 3 h after reperfusion (late treatment). There was no difference in myocardial eNOS expression between any groups studied. Myocardial iNOS expression was detected at 3 h after reperfusion but not at 1 h after reperfusion. Administration of l-arginine 10 min before reperfusion markedly decreased TUNEL-positive staining cardiomyocytes, reduced myocardial caspase-3 activity, inhibited iNOS expression, and reduced myocardial nitrotyrosine content. In strict contrast, administration of l-arginine 3 h after reperfusion, a time point when iNOS was expressed, resulted in a significant increase in myocardial NOx content, myocardial injury, and toxic peroxynitrite formation as measured by nitrotyrosine. Conclusion: Our results demonstrated for the first time that l-arginine administered at different time points during ischemia/reperfusion exerted different effects on post-ischemic myocardial injury, and suggests that stimulation of eNOS reduces nitrative stress and decreases apoptosis whereas stimulation of iNOS increases nitrative stress and enhances myocardial reperfusion injury.
Eosinophilic Fasciitis
Authors: R.B. LEWIS
Journal: Annals of Internal Medicine (1978)

Letters and Corrections1 April 1978Eosinophilic FasciitisR.B. LEWIS, M.D., W.B. VAN VALKENBURG, M.D.R.B. LEWIS, M.D.Search for more papers by this author, W.B. VAN VALKENBURG, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-88-4-577_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Recently the syndrome of eosinophilic fasciitis (sclerodermalike skin condition, peripheral eosinophilia, hypergammaglobulinemia, and thickening of the deep fascia with collagenous tissue and infiltration with lymphocytes and plasma cells) has been described. The patients usually have been males, and the disease often follows heavy exercise (1, 2). The response to corticosteroids has been notable (3). The long-term prognosis is unknown. We report here a similar syndrome in a patient who responded to steroids, with normal findings 17 years later.A 57-year-old white woman went to her private physician in 1960 with diffuse swelling of her arms, hands, and...References1. SHULMAN L: Diffuse fasciitis with hypergammaglobulinemia and eosinophilia. A new syndrome (abstract)? J Rheumatol 1 (suppl 1):46, 1974 Google Scholar2. SCHUMACHER H: A scleroderma-like syndrome with fasciitis, myositis, and eosinophilia (letter). Ann Intern Med 84:49-50, 1976 LinkGoogle Scholar3. RODNAN G, DIBARTOLOMEO A, MEDSGER T, and BURNES E: Eosinophilic fasciitis: report of seven cases of a newly recognized scleroderma-like syndrome (abstract). Arthritis Rheum 18:422-423, 1975 Google Scholar4. SIEGEL R: Scleroderma. Med Clin North Am 61:283-297, 1977 CrossrefMedlineGoogle Scholar5. BENNETT R, HERRON A, and KEOGH L: Eosinophilic fasciitis. Case report and review of the literature. Ann Rheum Dis 36:354-359, 1977 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: R.B. LEWIS, M.D.; W.B. VAN VALKENBURG, M.D.Affiliations: Veterans Administration Hospital Little Rock, AR 72206 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEosinophilic Fasciitis in a Pediatric PatientEosinophilic fasciitis in childrenEosinophilic fasciitis in a two-year-old childEosinophile Fasziitis (Shulman-Syndrom)Clinical spectrum of fascial inflammationEosinophilic fasciitis ultrastructural study of an early biopsied caseEosinophilic fasciitis: report of a 22-year followup studyFasciitis with Eosinophilia:.The fascia in systemic sclerodermaDiffuse Fasciitis and Eosinophilia with Symmetric PolyarthritisJEROME ROSENTHAL, M.D., MERRILL D. BENSON, M.D.Generalized Morphea with Peripheral Eosinophilia, Fasciitis and MyositisEosinophilic fasciitisCase 31-1979 1 April 1978Volume 88, Issue 4Page: 577-578KeywordsEosinophiliaExerciseHypergammaglobulinemiaInflammationLymphocytesPlasma cellsSteroids ePublished: 1 December 2008 Issue Published: 1 April 1978 PDF downloadLoading ...
Libel and medicine.
Authors: Bruce Ward, John Shepherd, John Monaghan Consultant
Journal: BMJ (1985)

for treated over control patients.This advantage was most definite in those patients with disease in the lymph nodes or with over half the cervix replaced by tumour.Further adjuvant studies with cisplatin containing com- binations are under way in Australia and in the United States.24All these studies include radiotherapy in either the control or chemotherapy arm.If survival figures are to be improved trials should be arranged to evaluate the place of chemotherapy alone in this apparently high risk group with "early" cervical carcinoma.
Book Review
Journal: British Journal of Dermatology (1994)

Abstract Book reviewed in this article: The Retinoids, Biology, Chemistry, and Medicine, 2nd edn. EDITED BY M.B.Sporn, A.B.Roberts AND D.S.Goodman (1994) Computer Applications in Dermatology, EDITED BY W.Stoecker (1993) Dermatology. An Illustrated Colour Text, D.J.Gawkrodger. (1992) Physical Signs in Dermatology. C.M.LAWRENCE AND N.H.COX (1993). Colour Atlas of Tropical Dermatology and Venereology. EDITED BY K.F.ScHALLER (1994)
BOOK REVIEWS
Authors: B. CADY
Journal: JNCI Journal of the National Cancer Institute (1988)

Journal Article BOOK REVIEWS Get access Surgical Treatment of Metastatic Cancer. Steven A. Rosenberg, ed. Philadelphia, PA: Lippincott, 1987, 286 pp. $59.50. BLAKE CADY BLAKE CADY 110 Francis St. Boston, MA 02115 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 80, Issue 9, 6 July 1988, Page 696, https://doi.org/10.1093/jnci/80.9.696 Published: 06 July 1988
From the Office of the General Counsel. Tobacco advertising and the first amendment
Authors: M. L. Ile
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal