tbuckley/cabot-search huggingface dataset:
Lipopolysaccharide-Induced Hepatic Injury Is Enhanced by Polychlorinated Biphenyls
Authors: Alan P. Brown, A. Eric Schultze, Wendy L. Holdan, John P. Buchweitz, Robert A. Roth, Patricia E. Ganey
Journal: Environmental Health Perspectives (1996)

After intravenous administration of bacterial lipopolysaccharide (LPS) to rats, polymorphonuclear neutrophils (PMNs) rapidly accumulate in the liver, and midzonal hepatic necrosis is prominent by 6 hr. PMNs are required for the development of hepatic injury in rats. Certain polychlorinated biphenyls (PCBs) can activate PMNs, resulting in production of superoxide anion (O2-.) and release of cytolytic factors from granules. This raises the possibility that PCB exposure might enhance PMN-mediated tissue injury, such as LPS-induced hepatotoxicity. We treated female Sprague-Dawley rats with a minimally toxic dose of LPS in saline (2 mg/kg, intravenous) and 90 min later exposed them to Aroclor 1248 (50 mg/kg, intraperitoneal), a mixture of PCBs. The animals were killed 6 hr after LPS administration, and hepatic injury was assessed. Neither LPS nor Aroclor 1248 alone produced liver injury. Co-treatment with LPS and Aroclor 1248 resulted in pronounced liver injury as demonstrated from increased activities of alanine aminotransferase and isocitrate dehydrogenase in plasma. Histological evaluation indicated increased severity of hepatic necrosis in rats receiving both LPS and Aroclor 1248. Hepatic accumulation of PMNs, normally observed after LPS, was not altered by co-exposure to PCBs. Aroclor 1248 stimulated rat PMNs in vitro to produce O2-. and to degranulate. In addition, PMN-mediated cytotoxicity to isolated rat hepatocytes in culture was increased upon addition of Aroclor 1248. PCBs activate PMNs in vitro and increase PMN-dependent hepatocellular damage in vitro and after LPS treatment in vivo. PCBs may act in vivo as an additional inflammatory stimulus to activate PMNs to become cytotoxic, resulting in increased tissue injury.
Recognizing symptom burden in advanced prostate cancer: A global patient and caregiver survey.
Authors: William K. Oh, Bertrand F. Tombal, Anthony Delacruz, Brian Tomlinson, Aimee Vella Ripley, Lawrence Drudge-Coates, Ken Mastris, Joe M. O'Sullivan, Neal D. Shore
Journal: Journal of Clinical Oncology (2016)

10124 Background: Symptoms may indicate disease progression in patients (pts) with advanced prostate cancer (aPC) but may not be recognized or communicated to health care providers (HCPs). Methods: To assess the impact of symptoms on daily life and how aPC pts communicate symptoms to their HCPs, the largest aPC pt survey to date (International Prostate Cancer Symptom Survey) was conducted online and by telephone by Harris Poll in 11 countries (Brazil, France, Germany, Japan, Italy, Netherlands, Singapore, Spain, Taiwan, UK, USA) from Feb 12 to Oct 27, 2015. Because sample sizes varied among countries, cell weighting was used to bring each country’s pts and caregivers to be equal in their respective totals. Results: Overall, 927 aPC pts and 400 caregivers were surveyed. Globally, 99% of pts with bone metastases experienced ≥ 1 symptom. Of pts with bone metastases, most had symptoms of fatigue (87%), pain in specific areas (83%), and generalized body pain (72%). Moreover, 73% of pts with bone metastases noticed pain before receiving a diagnosis of aPC (40% had pain for ≥ 7 months and 33% for < 7 months). Most aPC pts (56%) were uncertain if the pain was cancer-related, 55% felt they had to live with daily pain, 45% sometimes ignored pain, 39% had difficulty talking about pain and 29% did not agree that managing pain was essential to effectively treat cancer. A majority of pts said they would be motivated to report pain if it helped increase quality of life (QoL, 65%) or longevity (57%), kept cancer from worsening (54%), or decreased pain (53%). Caregivers report accompanying pts to 70% of HCP visits and 50% of pts rely on caregivers to ask the most important questions. Pts with a caregiver were more likely than those without to say pain is discussed at every visit (45% vs 32%, P= 0.031). Significantly more caregivers agreed with the statement that pain somewhat or strongly limited patients’ activities (72% of caregivers vs 54% of patients; P< 0.0001). Conclusions: Symptoms in aPC are often under recognized. Tools encouraging effective communication between pts/caregivers and HCPs on early symptom reporting and treatment may lead to earlier symptom identification and control. Enhanced discussion of approved therapies may improve QoL and patient outcomes.
Documentation of continuing medical education--an idea whose time has come
Authors: C. W. Mangun
Journal: JAMA (1972)

Regular readers of<i>JAMA</i>editorials may recognize the above title from an editorial that appeared in the Aug 14, 1972, issue. That editorial summarized the development and present status of programs sponsored by state medical associations and medical specialty societies for the documentation and certification of continuing medical education activities carried out by physicians. Both voluntary and required programs were mentioned. In addition, it was pointed out that three state boards of medical examiners have authority to require evidence of continuing medical education as a condition for the reregistration of the license to practice medicine. This editorial presents information on recent developments and again calls attention to the American Medical Association Physician's Recognition Award as a means of documenting continuing medical education that can serve all the profession. Six state medical associations have made policy decisions that will in effect require continuing medical education as a condition of membership—Oregon, Arizona,
Epidemiology of Hypertension as a Public Health Problem: An Overview as Background for Evaluation of Blood Lead-Blood Pressure Relationship
Authors: Herman A. Tyroler
Journal: Environmental Health Perspectives (1988)

An overview of the epidemiology of blood pressure is presented as background for the International Symposium of Blood Lead-Blood Pressure Relationships. The correlates of blood pressure distributions in populations are varied and numerous. They have to be considered as either potential confounders or modifiers of any blood pressure-blood lead relationship detected. The relation of blood pressure to cardiovascular morbidity and mortality emphasizes the importance of detecting and elucidating any possible causal association of blood lead with blood pressure at low levels. The task of this symposium is of public health importance, as relatively minor changes in the distribution and mean levels of blood pressure in populations are associated with major morbidity and mortality consequences.
Marijuana
Authors: Donald W. Goodwin
Journal: JAMA (1970)

"La Cucaracha" is a song about a cockroach hooked on marihuana. The composer obviously was not a botanist or he would have known that insects dislike cannabis. They refuse to consume the plant or even pollinate it, leaving such arts to man and the wind. This book is about cannabis, its use by man, and about wind: the gales of marihuana buffet a confused public. The author, an anesthesiologist, takes an arthropodal view of marihuana—he opposes it—but the book is not a moral tract. It is informative, lucid, entertaining, and, for laymen, probably the best balanced and most useful book available on the subject today. It is useful whether you want to grow cannabis (flooded plains are best); buy cannabis (it is cheapest in the fall); dry cannabis (set the heat of your dryer at "Cotton"); or talk about cannabis ("wig" means mind, "wig out" to blow same). It is
Vote of Confidence for FDA Advisory Committees, but Conflict of Interest Questions Remain
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lectures on Midwifery for Midwives.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
RADIATION INJURY
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
4. Indolent Lymphomas
Authors: R Somogyi, L Greller, T Baetz, D Lebrun, P Farmer, R Sidhu, K Harrison, H Feilotter, C Brodie, K Naresh, B Pro, F Cabanillas, L Fayad, Indolent Pretreated, S Non-Hodgkin', M Lymphoma, G Fina, L Musuraca, V Alinari, M Stefoni, A Tani, E Gabriele, S Marchi, M Pileri, P Baccarani, E Kalinka, J Wajs, K Sulek, M Blasinska-Morawiec, T Robak, J Holowiecki, J Sawczuk-Chabin, B Ceglarek, L Konopka, W Jedrzejczak, P Centkowski, K Warzocha
Journal: Annals of Oncology (2005)
Error in Table Footnote
Journal: JAMA (1982)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Utility of Different Lipid Measures to Predict Coronary Heart Disease—Reply
Authors: Erik Ingelsson, Michael J. Pencina, Ralph B. D’Agostino, Ramachandran S. Vasan
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Isolated lactase deficit in the adult: a present view
Authors: A. Littman
Journal: JAMA (1966)

What a joy to the clinician to find the arcane skills of research scientists directed to such matters as bloating, flatulence, cramps, and diarrhea! It is now clear that these symptoms can be caused by milk and other foods containing lactose in many persons deficient in the intestinal enzyme lactase. Rapidly moving research has localized lactase, the enzyme that splits lactose into glucose and galactose, and other disaccharidases to the intestinal epithelium. Peroral biopsy specimens of jejunal mucosa can be assayed accurately, providing the basis for a new field of investigation. As Kern and Struthers point out in this issue (p 927), when mucosal lactase is deficient, lactose is absorbed poorly from the intestinal lumen. Its osmotic activity results in great influx of water through the intestinal wall—more than 1,400 ml in one experiment—followed by cramps and watery diarrhea. As unabsorbed lactose reaches the lower intestine, rapid fermentation takes place,
THE PERMEABILITY OF THE INTESTINAL WALL TO BACTERIA.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Varicella Pneumonia.
Authors: R. H. Mermelstein
Journal: Annals of Internal Medicine (1961)

s1 May 1961Varicella Pneumonia.R. H. Mermelstein, M.D., A. W. Freireich, M.D., F.A.C.P.R. H. Mermelstein, M.D.Search for more papers by this author, A. W. Freireich, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-54-5-1056_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThis communication reports the largest series to date of patients with varicella pneumonia and is the only large series without a mortality. Thirty-eight patients with chickenpox (adults over 13 years of age) were hospitalized at Meadowbrook Hospital from January, 1953, through July, 1960. Thirteen of them had typical x-ray findings of chickenpox pneumonia. The severity varied from five cases who were asymptomatic to several who were almost moribund.Four cases are presented in detail, with x-rays and an accompanying table summarizing the salient features of the 13 cases. The clinical features are discussed with regard to course, treatment, prognosis, and... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1961Volume 54, Issue 5Page: 1056-1056KeywordsChickenpoxMortalityPneumonia ePublished: 1 December 2008 Issue Published: 1 May 1961 PDF downloadLoading ...
In Vivo Control of Acute Lymphoblastic Leukemia by Immunostimulatory CpG Oligonucleotides.
Authors: Gregor S.D. Reid, Hisaki Fujii, Jacqueline Trudeau, Junior Hall, Jonathan D. Fish, David T. Teachey, Valerie I. Brown, Kirk R. Schultz, Stephan A. Grupp
Journal: Blood (2006)
Family tree can yield lifesaving knowledge for patients at risk for hereditary cancers
Authors: T. Randall
Journal: JAMA (1992)

FOR MOST WOMEN, a 1 in 9 chance of developing breast cancer in a lifetime is a frightening prospect. Yet for a significant number of women, the odds are much higher than this. Women from certain families, in which breast cancer is an inherited autosomal dominant trait, face odds of 1 in 2. Between 4% and 9% of all breast cancers are believed to be dominantly inherited in the classic Mendelian sense. This may account for as many as 15 000 cases a year. Either parent can pass on the trait to the daughter. (The father would be an "obligate carrier.") The cancer typically occurs 15 to 20 years earlier than usual, bilaterally, or with tumors in other organs, particularly the ovaries. The idea that cancer can follow the classic laws of Mendelian genetics in certain families received a chilly reception from cancer researchers when it was first proposed several
Studies on Gastrointestinal Cells
Journal: BMJ (1974)

Compensation for InjuryThe Royal Comnission on Civil Liability and Compensation for Personal Injury, who began by inviting evidence on injuries suffered in the course of employment and road transport injuries, are now extending their invitation to the remaining areas of their remit.These are: death or personal injury "through the manufacture, supply or use of goods or services; on premises belonging to or occupied by anotrher; or otherwise through the act or omission of another where compensation under the present law is recoverable only on proof of fault or under the rules of strict liability.
Cherapeutics.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PROCUREMENT AND ASSIGNMENT SERVICE FOR PHYSICIANS, DENTISTS AND VETERINARIANS
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Contents
Authors: Shivananda Narayana, Tiruvengada Krishnan, Seema Ramakrishnan, Prativa Samantaray, Ariana Austin, Julia Pickel, Travis Porco, Tom Lietman, Jennifer Rose-Nussbaumer, Prajna Lalitha, Gerami Seitzman, Ritesh Kotecha, Armin Hinterwirth, Cindi Chen, Lina Zhong, Susie Cummings, Elodie Lebas, Malaya Sahoo, Benjamin Pinsky, Thomas Lietman, Thuy Doan, Rei Sakata, Takeshi Yoshitomi, Aiko Iwase, Chota Matsumoto, Tomomi Higashide, Motohiro Shirakashi, Makoto Aihara, Kazuhisa Sugiyama, Makoto Araie, Christopher Stewart, Geoffrey Rose, Irene Kuo, Julia Sammons
Journal: Ophthalmology (2019)