tbuckley/cabot-search huggingface dataset:
ACUTE PANCREATITIS.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Seriousness of Venereal Disease.
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Insufficient deletion of autoreactive CD4 T cells and plasticity of Tregs drive spontaneous autoimmune hepatitis in mice
Authors: Max Preti, Lena Schlott, David Luebbering, Daria Krzikalla, Anna-Lena Müller, Miriam Schakat, Sören Alexander Weidemann, Ansgar W. Lohse, Dorothee Schwinge, Christoph Schramm, Christina Weiler-Normann, Antonella Carambia, Johannes Herkel
Journal: Journal of Hepatology (2020)
Correction
Authors: H Bathurst
Journal: BMJ (1954)

JOURTUwLthe "undistinguished" consultant subsists on a part-time salary based on income rates ruling in the year 1938-9, plus 20%.He is at the present time worse off than the majority of his general-practitioner colleagues.Any funds available for distribution as a " betterment" factor for consultants are likely to be limited.It would be following accepted principles if in the first instance some in- crease should be granted to the worst-paid group.Those who are clearly without distinction and are prepared to accept this fact as a permanent disability might well be granted a modest betterment increment as a consola- tion prize.It is unnecessary to stress the importance of maintaining secrecy in the payment of such awards based as they will be upon the absence of professional merit.-Iam, etc.,
Transfusion in patients with massive blood loss: evidence when, for whom and what products are best
Authors: Jaap Jan Zwaginga
Journal: HemaSphere (2018)

Department of Immunohematology and Blood transfusion and the Center for Clinical Transfusion Research, Sanquin Research, Leiden University Medical Centre, Leiden, The Netherlands This is an open access Abstract Book distributed under the Attribution-NonCommercial-NoDerivs (CCBY-NC-ND), which allows third parties to download the abstracts and share them with others as long as they credit the author and the abstract book, but they cannot change the content in any way or use them commercially. http://creativecommons.org/licenses/by-nc-nd/4.0
Announcement: Interactive Atlases of Diabetes, Obesity, and Physical Inactivity Available Online
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction for Euro Surveill. 2020;25(28)
Journal: Eurosurveillance (2021)

© This work is licensed under a Creative Commons Attribution 4.0 International License. Closure This is a corrected article applying to the following content: Convalescent plasma treatment for SARS-CoV-2 infection: analysis of the first 436 donors in England, 22 April to 12 May 2020
Abstract 122: Stromal extracellular matrix is a microenvironmental cue promoting resistance to EGFR tyrosine kinase inhibitors in lung cancer cells
Authors: Ting Zhang, Lixia Guo, Yuanyuan Wang, Tao Ren, Yanan Yang
Journal: Cancer Research (2019)

Abstract The acquisition of resistance to EGFR tyrosine kinase inhibitors (TKIs) remains a critical problem in lung cancer clinic, but the underlying mechanisms have remained incompletely understood. Although the TKI-induced or -selected genetic changes are known to drive resistance, resistance also occurs in tumor cells without genetic changes through poorly-characterized processes. Here, we show that the extracellular matrix (ECM) from various components of the tumor microenvironment, including neighboring tumor cells and fibroblasts, may be the driver of resistance in the absence of genetic changes. Unlike genetic changes, which may evolve during relatively long time of chronic EGFR TKI treatment to drive resistance, briefly culturing on de-cellularized ECM, or co-culturing with the ECM donor cells, immediately confers resistance to tumor cells that are otherwise sensitive to EGFR TKIs. We show evidence that collagen in the ECM may be its primary constituent driving resistance, at least partly through the collagen receptor Integrin-β1. Intriguingly, such effect of ECM and collagen is dose-dependent and reversible, suggesting a potential clinic-relevant application for targeting this effect. Collectively, our results reveal that the stromal ECM acts as a microenvironmental cue promoting EGFR TKI resistance in lung cancer cells, and targeting collagen and Integrin-β1 may be useful for treating resistance, especially the resistance without clearly-defined genetic changes, for which effective therapeutics are lacking. Citation Format: Ting Zhang, Lixia Guo, Yuanyuan Wang, Tao Ren, Yanan Yang. Stromal extracellular matrix is a microenvironmental cue promoting resistance to EGFR tyrosine kinase inhibitors in lung cancer cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 122.
Katsusaburo Yamagiwa (1863-1930)
Journal: CA A Cancer Journal for Clinicians (1977)

â€oe¿ Cancer was produced!Proudly I walk a few stepsâ€• A devotee of Japanese Haiku poetry, Katsusaburo Yamagiwa thus expressed his profound satisfaction after experi mentally inducing squamous cell carci noma, for the first time, in 1915.After 250 days of painstakingly painting crude coal tar on the inner surface of rabbits' ears, Yamagiwa and his assistant, Koi chi Ichikawa, demonstrated that chronic irritation could cause cancer.Yamagiwa, then Director of the Department of Pathology at Tokyo Im perial University Medical School, had theorized that repetition or continuation of chronic irritation caused precan cerous alterations in previously normal epithelium.If the irritant continued its action, carcinoma could result.These data, publicly presented at a special meeting of the Tokyo Medical Society and reprinted below, focused attention on chemical carcinogenesis.Further more, his experimental method pro vided researchers with a means of pro ducing cancer in the laboratory and an ticipated investigation of specific carci nogenic agents and the precise way in which they acted.Within a decade, Keller and associates extracted a highly potent carcinogenic â€˜¿ hydrocarbonfrom coal tar.Dr. Yamagiwa had begun a new era in cancer research.
Malpractice
Authors: Thomas C. Hullverson
Journal: JAMA (1977)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Seventh Congress of the Italian Association of Neuro-Oncology (AINO)&lt;subtitle&gt;October 29–31, 2001 Turin, Italy&lt;/subtitle&gt;
Journal: Neuro-Oncology (2001)

calculation of the 75% inhibitory concentration (IC 7s ) on cell growth in triplicate experiments.Both drugs dose-dependently inhibited U-373 MG cell proliferation; the IC 7s s of temozolomide and stautosporine were 38.7±3.1 pM and 24.0±1.8nM, respectively.The IC 7s of temozolomide in combination with staurosporine was 5.7±1.5 pM, indicanting a substantial enhancement in the cytotoxicity of the alkylating agent.These data suggest that temozolomide may be used in combination with protein kinase inhibitors to further improve the anticancer activity of the drug.
Encephalomyocarditis
Authors: OTTO SAPHIR
Journal: Circulation (1952)

Simultaneously occurring inflammations of the cerebrospinal system and myocardium are rare if one excludes poliomyelitis. The encephalomyocarditis virus and related strains have been shown to produce such lesions. Three instances in man are related and the reasons for a possible virus origin of this disease entity are given. A plea is made for virus studies in other pertinent cases.
HYPOPROTEINEMIA
Authors: ELI MOSCHCOWITZ
Journal: JAMA (1933)

In 1891, Csatáry<sup>1</sup>showed that there was a decrease in the total plasma proteins in certain forms of nephritis and that the albumin fraction was lower than the globulin. The significance of this observation was lost until Epstein,<sup>2</sup>in a series of studies, confirmed it and found it applicable only in those forms of renal disorders then designated as "nephrosis," a term coined to connote diseases of the kidney that are not "inflammations." The dominant clinical evidence of "nephrosis" is dropsy. Epstein held that the dropsy was the result of the loss of protein by way of the kidneys and was associated with hypoproteinemia. In order to explain the relation of the hypoproteinemia to the dropsy, he applied the neglected law of Starling. Starling showed that the exchange of water between the blood and the body tissues depended on a balance between the colloidal osmotic pressure of the
Abstract 2775: Establishment of patient primary gastric cancer xenograft models for test of anticancer agents.
Authors: Ning Zhang, Shengyi You, Wenwei Li, Wen Zhou, Yong Liu, Rui Zhou, Fang He, Changnian Liu
Journal: Cancer Research (2013)

Abstract Background. Human xenograft tumor models established by inoculating human tumor cell lines into immunodifficient mice have been routinely used for preclinical test of anticancer agents. But tumor cell lines have a relatively low transplantability, which resulted in a limited number of tumor models available for selection of right tumor modes for test of targeted therapeutics. Recently, we have developed a large number of patient primary gastric cancer xenograft models by transplanting human fresh gastric tumor fragments into nude mice, which have been employed for preclinical test of clinically used drugs and novel anticancer agents for their chemosensitivity screening. Mehtods. The fresh gastric tumor samples were collected from local hospitals. The tumor fragments of 2-3 mm were subcutaneously implanted in the flanks of nude mice by trocar needle. Sixteen tumor fragments were grafted into four mice from one patient tumor tissue (passage 0). The clinically used drugs included 5-FU, gemcitabine, and doxorubicin. The histology and gene sequence of the established primary gastric tumor models were analyzed and compared with patients’ original tumors. Results. A total of 110 patient gastric cancer samples were implanted into nude mice; and 30 primary tumor models have been established with a tumor taking rates of 27% for the first passage. The tumor taking rates were higher in the later passages ranged from approximately 70-95%. The therapeutic efficacy of the test anticancer drugs was consistent with their clinical findings. The patients’ primary gastric cancer xenografts from all 5 passages retained a similarity in architecture, histopathological morphology, and genomic mutation status to their patients’ original tumors. Conclusions. The patient primary tumor model system can provide a larger number of models within same tumor histological type for selection of right models for preclinical testing novel agents based on their anticancer mechanism. The primary tumor models retain a similarity in histology and genomic mutation status to their patients’ original tumors. They may predict more relevant clinical response rate and higher correlation with clinical findings than use of traditional xenograft models established from long-term cultured cancer cell lines. Especially, they have advantages for test of target-oriented therapeutics in new drugs discovery and development programs. Citation Format: Ning Zhang, Shengyi You, Wenwei Li, Wen Zhou, Yong Liu, Rui Zhou, Fang He, Changnian Liu. Establishment of patient primary gastric cancer xenograft models for test of anticancer agents. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2775. doi:10.1158/1538-7445.AM2013-2775
Patient reported distress symptoms in patients undergoing palliative radiotherapy.
Authors: Megan Paige Single, Laeticia Hollant, Katherine Gaines, Bridget Smart, Jacob Habboush, Heather Biers, Atiya Day, Laura Vallow, Katherine S. Tzou, Byron C. May, Robert Clell Miller
Journal: Journal of Clinical Oncology (2016)

e18085 Background: The focus of palliative radiotherapy (RT) is on improving quality of life (QOL) for patients with serious illnesses by eliminating or decreasing physical symptoms. The importance of assessing distress levels in palliative care patients is recognized due to the relevance of QOL, as treatment is given to provide symptom-relief rather than curative results. We sought to identify the most common causes of patient reported distress during palliative RT. Methods: Retrospective review was performed for patients who received palliative RT from 11/1/2012 to 6/4/2015 for various types of metastatic cancer at our institution. All patients completed a Patient Reported Distress (PRD) questionnaire with 30 specific questions and an overall distress thermometer prior to beginning treatment. The PRD survey quantified 30 areas of current concern ranging in patient-reported values from 1 to 5 in addition to a linear analog measure from 0 to 10 of overall reported distress in the last month. Results: Completed PRD surveys were available for a total of 297 patients, 149 (50.2%) female and 148 (49.8%) male. All patients were undergoing external beam radiation therapy for treatment of metastatic disease. 49 (16%) received chemotherapy and 46 (9%) underwent surgery. Overall distress ranged from 0 to 10, with a median of 5.0. The mean distress scores for the top five concerns ranged from 1.4 to 2.7. Top distresses were “Fatigue” (2.7), “Pain that affects daily functioning” (2.6), “How will I feel during treatment” (2.5), “Sleep difficulties” (2.4), and “Out of pocket medical costs” (2.3). Least troubling symptoms were “Transportation” (1.4), “A loved one relying on me for their physical care” (1.5), “My job” (1.5), “Housing during treatment” (1.5), “Spirituality” (1.5), and “Anger” (1.5). Conclusions: Patients demonstrated concern for distress related to interruption of activities of normal life, such as tiredness and insomnia, pain, and overall burdens from treatment. Medical costs were also a major concern. Importantly, housing and transportation were not issues in the current study but could be of concern in other regions. Providers should be aware that patients’ primary concerns may not be directly related to the symptom being palliated.
Analysis and management of renal failure in fourth MRC myelomatosis trial. MRC working party on leukaemia in adults.
Authors: C Maclennan, C Allan, D Bagshawe, P Barkhan, A Bellingham, J Boughton, C Bunch, S Callendar, D Catovsky, H Cuckle, J Cuzick, I Delamore, J Durrant, I Fraser, A Galton, P Hamilton, G Hayhoe, J Hobbs, R Hutchinson, E Kay, G Mcdonald, G Marsh, E Mayne, R Peto, R Powles, A Prentice, E Preston, J Rees, G Rees, S Roath, E Roberts, I Temperley, R Thompson, G Wetherley-Mein, J Whittaker, D Winfield
Journal: BMJ (1984)

During March 1980 to February 1982, 73 out of 80 patients in renal failure admitted to the fourth MRC myelomatosis trial were managed by a planned policy of high fluid intake (greater than or equal to 3 1/24 h) in addition to receiving one of the two chemotherapeutic regimens being tested in the main trial. Patients were also randomised to receive either sodium bicarbonate to render their urine neutral or no supplement. Follow up continued till death or to April 1983. Of 49 patients who survived more than 100 days, 39 achieved reversal of their renal failure (18 complete, 21 partial). Recovery of renal function, as assessed by a fall in the serum creatinine concentration, was achieved even when light chain proteinuria persisted. Partial recovery of renal function was associated with prolonged useful life in several patients. In only 14 of the 80 patients studied was death directly attributable to renal failure. Survival of patients in the study was appreciably better than in equivalent groups of patients in other MRC trials in which less stringent policies of fluid intake were used. Patients randomised to receive alkali fared marginally better than the others, but the difference was not significant. These results show that in many cases patients with myelomatosis who develop renal failure may have this complication reversed by taking a high fluid intake. Furthermore, though light chain is an essential component of renal disease in these patients, other factors are also important and are accessible to treatment.
Disseminated sporotrichosis
Authors: N. E. Aronson
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
American Radium Society Seventieth Annual Meeting
Journal: JNCI Journal of the National Cancer Institute (1987)

American Radium Society Seventieth Annual Meeting Get access JNCI: Journal of the National Cancer Institute, Volume 79, Issue 5, November 1987, Page 1173, https://doi.org/10.1093/jnci/79.5.1173-f Published: 01 November 1987
Time
Authors: Jerome S. Reich
Journal: Annals of Internal Medicine (1998)

Letters15 April 1998TimeJerome S. Reich, MDJerome S. Reich, MDNorth Miami Beach, FL 33169Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-8-199804150-00031 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Dr. Davidoff's editorial on the amount of time physicians spend with their patients [1] merely skirts the issue of quality care that so many of us who have been practicing medicine in communities have been concerned about for some time.Unfortunately, the trend of the late 1990s (generated by the government's cutback in spending for preventive programs and by the insurance companies), especially managed care companies' lack of interest in quality care, is driving physician–patient relationships into shorter and less preventive encounters.Although everybody claims to be interested in preventive care, the facts of medical practice are ...References1. Davidoff F. Time [Editorial]. Ann Intern Med. 1997; 127:483-5. Google Scholar Author, Article, and Disclosure InformationAffiliations: North Miami Beach, FL 33169 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 April 1998Volume 128, Issue 8Page: 698KeywordsChild healthDiagnostic radiologyElderlyHealth care qualityHealth maintenance organizationsHematologic testsMammographyObstetrics and gynecologyPreventive medicineThorax Issue Published: 15 April 1998 CopyrightCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...