tbuckley/cabot-search huggingface dataset:
Lung Cancer: New Circulation Concept
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reply
Authors: Elana J. Bernstein, Dinesh Khanna, David J. Lederer
Journal: Arthritis & Rheumatology (2018)

Arthritis & RheumatologyVolume 71, Issue 2 p. 327-328 Letters Reply Elana J. Bernstein MD, MSc, orcid.org/0000-0001-5560-6390 Columbia University Medical Center, New York, NYSearch for more papers by this authorDinesh Khanna MD, MS, University of Michigan, Ann Arbor, MISearch for more papers by this authorDavid J. Lederer MD, MS, orcid.org/0000-0001-5258-0228 Columbia University Medical Center, New York, NYSearch for more papers by this author Elana J. Bernstein MD, MSc, orcid.org/0000-0001-5560-6390 Columbia University Medical Center, New York, NYSearch for more papers by this authorDinesh Khanna MD, MS, University of Michigan, Ann Arbor, MISearch for more papers by this authorDavid J. Lederer MD, MS, orcid.org/0000-0001-5258-0228 Columbia University Medical Center, New York, NYSearch for more papers by this author First published: 22 October 2018 https://doi.org/10.1002/art.40762Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume71, Issue2February 2019Pages 327-328 RelatedInformation
Detection of hepatitis B virus DNA in paraffin-embedded liver tissues in chronic hepatitis B or non-A, non-B hepatitis using the polymerase chain reaction
Authors: M Shindo
Journal: Hepatology (1991)

We developed a polymerase chain reaction assay for the direct detection of hepatitis B virus in paraffinembedded liver tissue and applied this assay to determine whether hepatitis B virus DNA exists in livers with chronic hepatitis non-A, non-B. Fifty five liver biopsy samples were studied: 11 from patients with HBeAg-positive chronic hepatitis (paraffin-embedded) and 44 from patients with chronic hepatitis non-A, non-B (21 paraffin-embedded 25 fresh frozen). Thirty three (75%) of the non-A, non-B cases were positive for hepatitis C virus antibodies. Approximately 1 to 10 ng of DNA was extracted from the paraffin-embedded tissue and amplified using oligonucleotide (23-mer) primers specific for the S gene (positions 261 to 692). The β-globin gene was used as an internal control for sensitivity because this is a single copy gene and allows for relative quantification. In each of the chronic hepatitis B livers, the expected 432-base-pair amplification product for hepatitis B virus DNA and β-globin gene product were both detected. On the other hand, in the 21 paraffin-embedded chronic hepatitis non-A, non-B livers, no hepatitis B virus DNA was detected, although β-globin gene was observed in all. Furthermore, in all 25 frozen non-A, non-B livers, β-globin gene was observed, but no hepatitis B virus band was seen. The limit of detection of hepatitis B virus DNA by this method was estimated to be one genomic copy of hepatitis B virus DNA per cell. Thus all patients with chronic hepatitis B, but no patients with clinically diagnosed non-A, non-B hepatitis, had hepatitis B virus DNA in liver at a level of or above one copy per hepatocyte. (HEPATOLOGY 1991;13:167–171).
Editorial Board
Authors: Treasa Creavin, Sara Cullinan, Feng Chen, Suado Nur, Lara Crow, Mat Mccutcheon, Philip Patenall, Neill Sharp, K Anderson, P Borst, C Epstein, G Fink, W Gehring, Switzerland Guarente, S Henikoff, J Hodgkin, H Horvitz, E Koonin, E Meyerowitz, S Moreno, D Sherratt, J Smith, M Takeichi, Japan Kobe, Stefan Washietl, Rainer Machné, Nick Goldman, Arturo Medrano-Soto, Debnath Pal, David Eisenberg, Mireya Plass, Eneritz Agirre, Diana Reyes, Francisco Camara, Eduardo Eyras, Michael Weedon, Timothy Frayling, Ana Cuervo, Inga Prokopenko, Mark Mccarthy, Cecilia Lindgren, Jason Bragg, Andreas Wagner, Gursharan Kalsi, Carol Prescott, Kenneth Kendler, Brien Riley, Alisdair Fernie, Nicolas Schauer
Journal: Trends in Genetics (2008)
Effect of hepatitis B virus X gene introduction on response to growth inhibition by transforming growth factor-?1. 2nd Dept. of Internal Medicine, Osaka Univ. Medical School, Japan
Journal: Hepatology (1995)

A series of novel aryl-substituted triazolyl d-galactosamine derivatives was synthesized as ligands for the carbohydrate recognition domain of the major subunit H1 (H1-CRD) of the human asialoglycoprotein receptor (ASGP-R). The compounds were biologically evaluated with a newly developed competitive binding assay, surface plasmon resonance and by a competitive NMR binding experiment. With compound 1b, a new ligand with a twofold improved affinity to the best so far known d-GalNAc was identified. This small, drug-like ligand can be used as targeting device for drug delivery to hepatocytes.
Radiation Enhances Silica Translocation to the Pulmonary Interstitium and Increases Fibrosis in Mice
Authors: Ian Y. R. Adamson
Journal: Environmental Health Perspectives (1992)

The effects of whole body irradiation (WBR) on particle clearance and the development of pulmonary fibrosis have been investigated. Using carbon, clearance is accomplished by polymorphonuclear leukocytes (PMN) and alveolar macrophages (AM), and only a few particles reach the interstitum. However, in preirradiated mice, the usual eflux of inflammatory cells is much delayed so that more free carbon remains in the alveoli, and by 1 week, many particles cross the epithelium to be phagocytized by interstitial macrophages. Carbon is found in the peribronchiolar interstitium 6 months later with no evidence of fibrosis. In the present study, mice received 1 mg silica intratracheally 2 days after 6.5 Gy WBR when the white blood cell count was low. A much-reduced AM and PMN response was found in the following 2 weeks compared to the reaction to silica alone, and many silica particles reached interstitial macrophages. In this case, macrophage activation by silica was associated with fibroblast proliferation, and by 16 weeks, much more pulmonary fibrosis was produced than after silica or irradiation only. This was measured biochemically and correlated with a large increase in retained silica in the irradiation-silica group. The results indicate that radiation inhibits the inflammatory response to particle instillation, resulting in greater translocation of free particles to the pulmonary interstitium. In the case of silica, the greater, prolonged interaction with interstitial macrophages leads to a much exaggerated fibrotic reaction.
Yale studies in family health care. 3. The health care team
Authors: J. S. Beloff
Journal: JAMA (1968)

The Family Health Care Project is an experimental attempt to answer the need for a health care system which will bridge the gap between patient needs and available but fragmented health resources. The health care team, which consists of physician, public health nurse, and health aide, coordinates the efforts of medical and allied medical personnel to give comprehensive health care to multiproblem urban families. There are difficulties in creating a coordinated health team, given the traditional role relationships of the doctors, nurses, and other health personnel. After 2 1/2 years of experience with this model, it was possible to develop an effectively functioning health team when communication techniques were improved. The data presented reveal the effect of health team delivery of care on utilization patterns of urban families.
Street Rounds
Authors: Cordelia Yen Ross
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dengue Fever Epidemic Potential as Projected by General Circulation Models of Global Climate Change
Authors: Jonathan A. Patz, Willem J. M. Martens, Dana A. Focks, Theo H. Jetten
Journal: Environmental Health Perspectives (1998)

Climate factors influence the transmission of dengue fever, the world's most widespread vector-borne virus. We examined the potential added risk posed by global climate change on dengue transmission using computer-based simulation analysis to link temperature output from three climate general circulation models (GCMs) to a dengue vectorial capacity equation. Our outcome measure, epidemic potential, is the reciprocal of the critical mosquito density threshold of the vectorial capacity equation. An increase in epidemic potential indicates that a smaller number of mosquitoes can maintain a state of endemicity of disease where dengue virus is introduced. Baseline climate data for comparison are from 1931 to 1980. Among the three GCMs, the average projected temperature elevation was 1.16 degrees C, expected by the year 2050. All three GCMs projected a temperature-related increase in potential seasonal transmission in five selected cities, as well as an increase in global epidemic potential, with the largest area change occurring in temperate regions. For regions already at risk, the aggregate epidemic potential across the three scenarios rose on average between 31 and 47% (range, 24-74%). If climate change occurs, as many climatologists believe, this will increase the epidemic potential of dengue-carrying mosquitoes, given viral introduction and susceptible human populations. Our risk assessment suggests that increased incidence may first occur in regions bordering endemic zones in latitude or altitude. Endemic locations may be at higher risk from hemorrhagic dengue if transmission intensity increases.
Transplacental Transport of Lead
Authors: Robert A. Goyer
Journal: Environmental Health Perspectives (1990)

Neurotoxicity is the major health effect from exposure to lead for infants and young children, and there is current concern regarding possible toxic effects of lead on the child while in utero. There is no placental-fetal barrier to lead transport. Maternal and fetal blood lead levels are nearly identical, so lead passes through the placenta unencumbered. Lead has been measured in the fetal brain as early as the end of the first trimester (13 weeks). There is a similar rate of increase in brain size and lead content throughout pregnancy in the fetus of mothers in the general population, so concentration of lead probably does not differ greatly during gestation unless exposure of the mother changes. Cell-specific sensitivity to the toxic effects of lead, however, may be greater the younger the fetus. Lead toxicity to the nervous system is characterized by edema or swelling of the brain due to altered permeability of capillary endothelial cells. Experimental studies suggest that immature endothelial cells forming the capillaries of the developing brain are less resistant to the effects of lead, permitting fluid and cations including lead to reach newly formed components of the brain, particularly astrocytes and neurons. Also, the ability of astrocytes and neurons to sequester lead in the form of lead protein complexes occurs only in the later stages of fetal development, permitting lead in maturing brain cells to interact with vital subcellular organelles, particularly mitochondria, which are the major cellular energy source. Intracellular lead also affects binding sites for calcium which, in turn, may affect numerous cell functions including neurotransmitter release.
The revolution in clinical immunology
Authors: A. S. Fauci
Journal: JAMA (1981)

<h3>Advances in Immunology</h3><h3>JAMA:</h3> In your opinion, what have been some of the major recent advances in immunology? <h3>Fauci:</h3> There have been a number of extremely exciting advances in the area of immunology during the past few years that surely will have relevance in clinical medicine [Table]. Three of the most important are (1) molecular genetic approaches to immunologic reactivity; (2) hybridization of immunocompetent cells; and (3) delineation of the regulatory mechanisms of the immune response. <h3>Molecular Genetic Approaches to Immunologic Reactivity</h3> This is an extremely complex and sophisticated area of research whereby scientists have been able to isolate and determine the DNA sequences of various genes involved in coding for critical immune functions. For example, sequencing of the genes that code for the heavy and light chains of immunoglobulin molecules has led to exciting realizations of how the genes lead to immunoglobulin production through physical rearrangements of the DNA.
Alcohol and Pregnancy: A Clinical Perspective
Authors: H. Rosett
Journal: Annual Review of Medicine (1985)

Exposure of the fetus at any gestational stage to high concentrations of alcohol can adversely affect growth, morphology, and neurophysiologic development. Sustained heavy drinking can result in the fetal alcohol syndrome. Cessation of heavy drinking during pregnancy will benefit both mother and child. Primary health care providers can effectively identify and treat women at risk.
IFP News Section
Authors: Antonella Gigantesco, Gabriella Palumbo, Fiorino Mirabella, Lisa Schneider, Manisha Vijayaraghavan, Maurizio Fava, A. John Rush, Christa Zimmermann, Thomas Heidenreich, Inka Tuin, Burkhard Pflug, Matthias Michal, Johannes Michalak, Yoshio Mino, Akira Babazono, Toshihide Tsuda, Nobufumi Yasuda, Elizeth Heldt, Carolina Blaya, Luciano Isolan, Leticia Kipper, Betina Teruchkin, Michael W. Otto, Marcelo Fleck, Gisele G. Manfro, Lisa Cosgrove, Mario Pettinelli, Pierluigi Morosini, Antonei B. Csoka, Dorothea Schulte, Harald Walach, Lidia Del Piccolo, Franco Benazzi, Siegfried Kasper, Michela Rimondini, Claudia Goss, Mariangela Mazzi, Monica Paccaloni, Edda Pjrek, Sheldon Krimsky, Ian R.H. Falloon, Stuart Shipko, Dietmar Winkler
Journal: Psychotherapy and Psychosomatics (2006)
AMERICAN ORTHOPEDIC ASSOCIATIONAnnual Meeting, held in Washington, D. C., May 3-5, 1910
Journal: JAMA (1910)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE SYNTHESIS OF THYROXIN
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Turning a blind eye: the success of blinding reported in a random sample of randomised, placebo controlled trials
Authors: Dean Fergusson, Kathleen Cranley Glass, Duff Waring, Stan Shapiro
Journal: BMJ (2004)

<h3>Abstract</h3> <b>Objective</b> To examine the reporting and success of double blinding in a sample of randomised, placebo controlled trials from leading general medicine and psychiatry journals. <b>Methods</b> Identification of placebo controlled, randomised controlled trials from prespecified general medical and psychiatric journals indexed on Medline between 1 January 1998 and 1 October 2001, from which a random sample of 200 randomised clinical trials was chosen, of which 191 trials were evaluated. <b>Results</b> Only seven of the 97 (7%) general medicine trials provided evidence on the success of blinding, with five reporting that the success of blinding was imperfect. In trials from psychiatric journals, the success of blinding was reported in eight of the 94 trials, with four reporting that the blinding was imperfect. Overall, only four of the 191 (2%) trials assessed blinding in the participants and either the outcome assessors or the investigators. <b>Conclusions</b> The current lack of reporting on the success of blinding provides little evidence that success of blinding is maintained in placebo controlled trials. Trialists and editors should make a concerted effort to incorporate, report, and publish such information and its potential effect on study results.
Erratum: Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients
Authors: Giulia Siravegna, Benedetta Mussolin, Michela Buscarino, Giorgio Corti, Andrea Cassingena, Giovanni Crisafulli, Agostino Ponzetti, Chiara Cremolini, Alessio Amatu, Calogero Lauricella, Simona Lamba, Sebastijan Hobor, Antonio Avallone, Emanuele Valtorta, Giuseppe Rospo, Enzo Medico, Valentina Motta, Carlotta Antoniotti, Fabiana Tatangelo, Beatriz Bellosillo, Silvio Veronese, Alfredo Budillon, Clara Montagut, Patrizia Racca, Silvia Marsoni, Alfredo Falcone, Ryan B Corcoran, Federica Di Nicolantonio, Fotios Loupakis, Salvatore Siena, Andrea Sartore-Bianchi, Alberto Bardelli
Journal: Nature Medicine (2015)
BOOK REVIEWS
Authors: S. SAKS
Journal: JNCI Journal of the National Cancer Institute (1989)

Journal Article BOOK REVIEWS Get access Tumor Necrosis Factor/Cachectin and Related Cytokines. Benjamin Bonavida, George E. Gifford, Holger Kirchner, Lloyd J. Old, eds. Basel, Switzerland: Karger, 1988, 276 pp. $132. SAMUEL SAKS SAMUEL SAKS Genentech, Inc.460 Point San Bruno South San Francisco, CA 94080 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 81, Issue 20, 18 October 1989, Page 1581, https://doi.org/10.1093/jnci/81.20.1581 Published: 18 October 1989
Induction of metallothionein gene expression by epidermal growth factor and its inhibition by transforming growth factor-β and dexamethasone in rat hepatocytes
Authors: Pierre Moffatt, Gabriel L. Plaa, Francine Denizeau
Journal: Hepatology (1995)

Metallothionein (MT) is a small cysteine-rich protein thought to be mainly involved in metal regulation and detoxification. The implication of MT in cell growth and differentiation has also been suggested. This latter hypothesis was further investigated in adult rat hepatocytes induced to proliferate by epidermal growth factor (EGF). Exposure of hepatocytes to EGF resulted in significant increases (≈twofold) in MT protein and MT-1 messenger RNA (mRNA) levels, which were maximal after 48 hours. As revealed by nuclear run-on analysis, these changes were the result of transcriptional activation. Increases of MT occurred concomitantly with stimulation of DNA synthesis (48 hours). Addition of ZnSO 4 or dexamethasone (Dex) was also effective at inducing MT protein (≈3.6 to 3.3 times) and mRNA. Combined addition of Zn and EGF produced an additive increase in MT protein and MT-1 mRNA levels. When both Dex and EGF were present together, the EGF-induced MT protein and mRNA expression was lost, whereas it had only minor inhibitory effects on DNA synthesis. Transforming growth factor beta (TGF-β), a known antagonist of EGF on hepatocytes, blocked the EGF-induced MT accumulation and stimulation of DNA synthesis. In addition, under the same conditions, the EGF-induced c- fos mRNA accumulation was blocked by Dex whereas TGF-β had no effect. These results show that growth factors believed to play a role in liver regeneration can also modulate MT gene expression in vitro. This modulation does not strictly parallel that of DNA synthesis. The possibility that c- fos stimulation may play a role in MT induction by EGF cannot be ruled out. (Hepatology 1995; 21:1038-1044.)
IgA NEPHROPATHY
Authors: A R Clarkson, A J Woodroffe, I Aarons, Y Hiki, G Hale
Journal: Annual Review of Medicine (1987)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease 2019 (COVID-19), emerged in China in December 2019 and quickly spread around the globe, killing more than 4 million people and causing a severe economic crisis. ...Read More