Familial Gynecomastia
Authors: STANLEY ROSEWATER
Journal: Annals of Internal Medicine (1965)

Article1 September 1965Familial GynecomastiaSTANLEY ROSEWATER, B.A., GRANT GWINUP, M.D., GEORGE J. HAMWI, M.D., F.A.C.P.STANLEY ROSEWATER, B.A., GRANT GWINUP, M.D., GEORGE J. HAMWI, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-3-377 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptGynecomastia has been reported in association with many systemic diseases (1-8), with pituitary, gonadal, and adrenal tumors (9-11), and secondary to drug administration and starvation (12-16). Gynecomastia has also been described in various hypergonadotrophic hypogonadal states (17, 18). Several families have been reported with gynecomastia associated with hypospadias (19-21). We have studied a family in which four males have presented with gynecomastia as a part of a syndrome not previously reported. An attempt has been made to elucidate the endocrine interrelationships leading to breast development in these males and to speculate about the causative mechanism.METHODSThe protein-bound iodine (PBI)...References1. SPANKUSGRANT WHRS: Gynecomastia. J. Clin. Endocr. 7: 586, 1947. CrossrefGoogle Scholar2. WHEELERCAWLEYGRAYCURTIS CEEPHTAC: Gynecomastia: a review and analysis of 160 cases. Ann. Intern. Med. 40: 985, 1954. LinkGoogle Scholar3. GREENBERGDIVERTIEWOOLNER EMBLB: A review of unusual systemic manifestations associated with carcinoma. Amer. J. Med. 36: 106, 1964. CrossrefMedlineGoogle Scholar4. BERSONSCHREIBER SASS: Gynecomastia and hyperthyroidism. J. Clin. Endocr. 13: 1126, 1953. CrossrefGoogle Scholar5. STARR P: Gynecomastia during hyperthyroidism. JAMA 104: 1988, 1935. CrossrefGoogle Scholar6. SHUSTERBROWN SJB: Gynecomastia and urinary oestrogens in patients with generalized skin disease. Lancet 2: 1358, 1962. CrossrefMedlineGoogle Scholar7. 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Hamwi, M.D., Professor of Medicine, Division of Endocrinology & Metabolism, University Hospitals, Columbus, Ohio 43210. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByMolecular basis of androgen insensitivity syndromesDisorders of Sex Development: Classification, Review, and Impact on FertilityNonneoplastic Diseases of the TestisClinical and Etiological Aspects of Gynecomastia in Adult Males: A Multicenter StudyCongenital LesionsPerspectives in Pediatric Pathology, Chapter 6. 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SACKS, M.D., I. SYLVIA CRAWLEY, M.D., JOHN A. WARD, M.D., ROBERT M. FINE, M.D.Comments on some genetic abnormalities of sex determination and sex differentiation in Homo sapiensThe Syndromes of Androgen ResistanceGenetic Disorders of Male Sexual DifferentiationGenetic and Chromosomal Evaluation in AndrologyA New Cause of Male InfertilityABNORMALITIES OF GONADAL FUNCTION IN MENTestisPartial Androgen InsensitivityMedical aspects of hypogonadism7 Gynaecomastia in male adolescentsIncomplete Male PseudohermaphroditismFamilial Incomplete Male Pseudohermaphroditism, Type 2Incomplete Male PseudohermaphroditismFamilial Incomplete Male Pseudohermaphroditism, Type 1TestisGenetic Disorders in Adolescents and Young AdultsFAMILIAL MALE PSEUDOHERMAPHRODITISMChromatin-negative hypogonadism in phenotypic men 1 September 1965Volume 63, Issue 3Page: 377-385KeywordsEstrogensExcretionLigation assayMedical servicesPrevention, policy, and public healthProteinsResearch grantsStarvationSystemic diseasesTestes Issue Published: 1 September 1965 PDF DownloadLoading ...