tbuckley/cabot-search huggingface dataset:
The 1995 JAMA Peer Reviewers
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Megaloblastic changes in the cervical epithelium. Association with oral contraceptive therapy and reversal with folic acid
Authors: N. Whitehead
Journal: JAMA (1973)

"Megaloblastic" abnormalities of cervicovaginal cells similar to those seen in severe folate and vitamin B<sub>12</sub>deficiency were found in 22 (19%) of 115 women taking oral contraceptive agents (combined estrogen-progestogen or progestogens only). Similar changes were not observed in any of 51 controls not taking these medications. The cytologic abnormalities could not be related to hematologic findings or serum folate and vitamin B<sub>12</sub>concentrations. The changes reverted to normal or improved markedly in all eight patients treated with pharmacologic doses of folic acid for three weeks. It is hypothesized that oral contraceptive agents induce a localized interference with folate metabolism at the end organ level.
BOOK REVIEWS
Authors: L. L. MILLER
Journal: JNCI Journal of the National Cancer Institute (1991)

Journal Article BOOK REVIEWS Get access Hematopoietic Growth Factors in Clinical Applications . R. Mertelsmann , F. Herrmann , eds. New York : Marcel Dekker, Inc. , 1990 , 496 pp. $99.75. LANGDON L. MILLER LANGDON L. MILLER Biologics Evaluation Section Cancer Therapy Evaluation Program National Cancer Institute Executive Plaza NorthRm. 715 Bethesda, MD 20892 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 19, 2 October 1991, Pages 1412–1413, https://doi.org/10.1093/jnci/83.19.1412-a Published: 02 October 1991
银屑病中的精神病和自杀行为
Authors: R. Parisi, R.T. Webb, C.E. Kleyn, M.J. Carr, N. Kapur, C.E.M. Griffiths, D.M. Ashcroft
Journal: British Journal of Dermatology (2019)

银屑病是一种长期皮肤疾病,当前没有治愈手段。很多银屑病患者还存在社会或情感问题,这称为心理社会合并症。针对银屑病患者中心理疾病的推荐解释包括银屑病对人们生活质量的显著影响,主要与他们的皮肤外观和这对他们生活的影响有关。认为银屑病患者中的心理负担可能导致自残和自杀的风险增高。这项来自英国的研究通过比较来自 56,961 名银屑病患者和 876,919 名无银屑病者的医学数据调查了这一理论。这些数据显示,银屑病患者中的酒精滥用、双相障碍、抑郁、焦虑障碍、自残和精神病药物(针对心理健康)处方更为常见。但是,尽管相比一般人群,银屑病组的自残风险增高 15%,银屑病患者中的总体自杀风险比无银屑病的患者低 40%。自杀风险随年龄变化;≥40 岁时诊断银屑病者的自杀风险较同年龄组无此病者降低 60%,而如果在 40 岁前诊断,两组的风险无任何差异。治疗银屑病患者的医疗保健专业人员应持续监测和有效应对这些个体的心理需求。
Pathological aspects and spread of carcinoma of the bladder
Authors: F. K. Mostofi
Journal: JAMA (1968)

The urinary bladder is the most easily accessible of the internal organs; its normal histologic charracteristics are quite simple, and most of its tumors are of epithelial origin. Yet, regrettably, there are no generally accepted pathological criteria for the diagnosis of malignancy, and there is no unanimity on a standard pathological classification or nomenclature of these tumors. What is designated as a papilloma by one pathologist may be called a urothelioma or a urothelial, papillary, transitional cell, or squamous cell carcinoma by others.<sup>11</sup>It has been impossible to assess the results of various forms of therapy or to compare epidemiologic, survival, mortality, or other data. It is the purpose of this communication to review the areas of disagreement and to propose a tumor classification of clinicopathologic value. <h3>Criteria for the Diagnosis of Carcinoma of the Bladder</h3> Although 97% of tumors of the bladder are of epithelial origin, and, in
HYPERSUSCEPTIBILITY.
Authors: M. J. ROSENAU
Journal: JAMA (1906)

<h3>(Abstract.)</h3> The phenomenon of hypersusceptibility has long been recognized, but has been overshadowed in modern studies on immunity. Instances of hypersusceptibility to certain infectious diseases, bacterial toxins and other substances may be found scattered through the literature. The well-known hypersusceptibility to tuberculin in animals infected with tuberculosis has received much attention, but the importance of hypersusceptibility in general pathology has not been realized. At first glance it would appear much more important for an organism to be<i>hyposensitive</i>than<i>hypersensitive</i>to infectious processes, but a closer study of the complex problems of immunity develops the curious fact that resistance to disease may be largely gained through a process of hypersusceptibility. Whether this increased susceptibility is an essential element or only one stage in the process of resistance to disease must now engage our attention. Von Pirquet and Schick<sup>1</sup>believe the immunity which an organism acquires after an attack of
Checkpoint Inhibitors Boost Power of Antibody–Drug Conjugate
Journal: Cancer Discovery (2015)

The antibody-drug conjugate T-DM1 spurs immune cells to infiltrate HER2-positive breast tumors in patients. Treating mice that carry breast tumors with T-DM1 improves survival, but the tumors suppress the infiltrating lymphocytes. Combining T-DM1 with checkpoint inhibitors that block CTLA-4 and PD-1 overcomes this effect, eliminating breast tumors from 95% of the mice.
WINTER BEDDING AND INFECTION.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Revolution in the laboratory.
Journal: BMJ (1968)

PointersMeasles Vaccination: Second Report to the M.R.C. shows immunization with either killed vaccine followed by live vaccine or live vaccine only gave high degree of protection against measles, but that this was greater with live vaccine.It concludes that there is a strong case for using live vaccine alone (p.449).Leader at p. 444.Oral Contraceptives: Dr. A. Nilsson and
Postprandial Drowsiness
Authors: Quentin R. Regestein
Journal: JAMA (1972)

<h3>To the Editor.—</h3> In reply to a question about problematic postprandial drowsiness, Dr. Kleitman suggests that the appeasement of hunger as well as stimulus monotony can lead to sleepiness, and prescribes the avoidance of heavy meals, subsequent monotony, and physical inactivity to prevent postprandial sleepiness (219:1486, 1972). Dr. Hauri adds that L-tryptophan intake may increase drowsiness (220:1135, 1972) and suggests avoiding tryptophan-rich foods in the diet, eg, meat and milk. Both of these viewpoints may relate to the same underlying brain mechanisms. Experimental evidence confirms Dr. Kleitman's point, since the electroencephalographic synchrony seen after appetite gratification<sup>1,2</sup>is functionally congruent to those electroencephalographic rhythms associated with decreased arousal.<sup>3</sup>Increases in brain concentrations of a tryptophan metabolite, serotonin, may cause slow-wave (or "synchronized") sleep<sup>4,5</sup>; however, the laboratory phenomenon of "postreinforcement synchrony" could be related to any type of gratification, meat-eating included. Drowsiness after sexual activity might provide another example.
Textbook of Rheumatology
Authors: George Ehrlich
Journal: JAMA (1997)

Rheumatology <i>Textbook of Rheumatology</i>, familiarly known to a generation of physicians as "the Kelley," became a classic upon publication of the first edition in 1981. Regularly as clockwork, successive editions have appeared each 4 years, following upon presidential elections in the United States. Kelley has appeared without the provincialism that characterized most books of the preceding decades of the century, whose authors generally were recruited in a single country and reflected that style of medical thinking. The new Kelley recognizes the globalism of rheumatology. Some of the authors have come to prominence because of their leadership in OMERACT (Outcome Measures in Rheumatoid Arthritis Clinical Trials), the international think tank that addresses new guidelines for unanimity. The format reflects what has worked before for this text. The first two sections address the basics: the structure and function of joints, connective tissue, and muscle, and immune and inflammatory responses. The 34 pages
Reimbursement for in vitro allergy tests
Authors: J. Bousquet
Journal: JAMA (1991)

<h3>To the Editor.—</h3> We read with great interest the Medical News &amp; Perspectives article<sup>1</sup>concerning reimbursement for in vitro laboratory tests for the diagnosis of allergy. Dr Russell I. Williams, Jr, presidentelect of the American In Vitro Allergy and Immunology Society, stated that "this test is reasonable, the cost-benefit ratio is reasonable." Later, he indicated that "it is actually in the Blues' [Blue Cross/Blue Shield] best interest to pay for in vitro tests because fewer patients with false-positive test results are given unnecessary immunotherapy." There is no doubt that IgE tests have significantly improved the diagnosis of immediate-type allergic diseases and have made many, if not a large proportion, of the provocative challenges obsolete. However, they do not solve all the problems of the diagnosis of allergy, and different tests can be used. Allergists favor skin tests, which appear to be more precise than in vitro tests, and they
Incorrect Title
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Unexpected late stillbirths are more common than sudden infant deaths
Journal: BMJ (1999)

Community exercise classes help people with back painAlthough patients with back pain should return to normal activities as soon as possible, many are afraid of further injury or making their pain worse and therefore reduce their activities.This can lead to chronic disability.Klaber Moffett et al (p 279) show that referring patients to a progressive exercise programme of eight evening sessions led by physiotherapists helped patients to cope better with their pain and function better.The benefits were maintained for at least a year, and patients' initial preferences for type of management did not affect outcome.Coxiella burnetii infection may be linked to cardiovascular disease
The Authors Reply
Authors: Shokei Kim-Mitsuyama, Hisao Ogawa, Kunihiko Matsui, Tomio Jinnouchi, Hideaki Jinnouchi, Kikuo Arakawa
Journal: Kidney International (2013)

We read with interest the letter by Fukuda and Miura,1.Fukuda M. Miura T. Awaiting the OSCAR subanalysis of subjects according to the presence of proteinuria.Kidney Int. 2013; 84: 1047Abstract Full Text Full Text PDF PubMed Scopus (1) Google Scholar in response to our article. As they commented, the degree of sodium intake is known to significantly affect the effectiveness of angiotensin II receptor blockers (ARBs) in patients with chronic kidney disease. However, in the OSCAR study, we did not monitor urinary sodium levels and therefore, the role of salt sensitivity in the OSCAR study is unclear. Furthermore, it is unknown whether the elderly patients enrolled in the OSCAR study exhibited glomerular hypertension or not. Unfortunately, measurement of urinary protein or albumin was not performed in the OSCAR study. However, 680 patients of 1164 enrolled patients had urinary protein test by dipstick analysis at baseline. According to the request, we present the subgroup analysis data according to the presence or absence of proteinuria at baseline (Figure 1). In patients with urinary protein +1 or greater, more primary events (a composite of cardiovascular events and non-cardiovascular death) occurred in the high-dose ARB group than in the ARB + calcium channel blocker (CCB) group (15 vs 5 events, hazard ratio (HR), 3.31, 95% confidence interval (CI) 1.12–9.8; P=0.0254). On the other hand, in patients with urinary protein – or ±, the incidence of primary events was similar between the two treatments (HR=1.13, 95% CI 0.61–2.09; P=0.7034). Thus, our subanalysis suggests that ARB+CCB combination, compared to high-dose ARB, conferred greater benefit in prevention of cardiovascular events in patients with proteinuria, being consistent with the findings2.Kim-Mitsuyama S. Ogawa H. Matsui K. et al.An angiotensin II receptor blocker-calcium channel blocker combination prevents cardiovascular events in elderly high-risk hypertensive patients with chronic kidney disease better than high-dose angiotensin II receptor blockade alone.Kidney Int. 2013; 83: 167-176Abstract Full Text Full Text PDF PubMed Scopus (39) Google Scholar on patients with estimated glomerular filtration rate of <60ml/min per 1.73m2. The superiority of ARB+CCB combination might be at least in part attributed to the potential improvement of renal blood flow through arterial vasodilation, because the elderly patients are characterized by significant vascular stiffness. However, further clinical study is required to define our proposal, as the number of patients in the OSCAR study is limited.
CHILDBED FEVER
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ADDRESSES.
Journal: JAMA (1889)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The changing neurourologic lesion in myelodysplasia
Authors: M. R. Spindel
Journal: JAMA (1987)

Seventy-nine newborns with myelodysplasia were followed up for 1 1/2 to six years with serial roentgenographic, neurologic, and urodynamic evaluations. Twenty-nine infants (37%) demonstrated changes in external urethral sphincter innervation during the first three years of life. Of the group who changed, 86% (25/29 infants) did so in the first year, 10% (3/29 infants) in the second year, and 4% (1/29 infants) in the third. The risk factor for change was 32%, 6%, and 2%, respectively, during each of these three years. Fifteen infants (19% of the total) experienced neurourologic deterioration while 14 infants (18%) improved. Seven newborns underwent a second neurosurgical procedure resulting in improvement in four, stabilization in two, and further deterioration in one. These findings underline the importance of early and continued neurologic and urologic surveillance in children with myelodysplasia because it is a dynamic disease process. (<i>JAMA</i>1987;258:1630-1633)
Compensatory Regeneration, Mitogen-Induced Liver Growth, and Multistage Chemical Carcinogenesis
Authors: Giovanna Maria Ledda-Columbano, Pierpaolo Coni, Gabriella Simbula, Ignazio Zedda, Amedeo Columbano
Journal: Environmental Health Perspectives (1993)

Liver cell proliferation has often been implicated to play a major role during different steps of the carcinogenic process.Most of the experimental studies indicating a close association between cell proliferation and liver cancer development have made use of a compensatory type of proliferative stimulus.However, liver growth may also be caused by direct hyperplasia after administration of primary mitogens.Our recent studies examined the possible differences between these two types of cell proliferation.Our studies indicate that a) increased expression of proto-oncogenes such as c-fos, c-jun, and c-myc is not necessary for entry into the cell cycle during mitogen-induced liver growth; b) mitogen-induced liver growth does not support initia- tion of chemical hepatocarcinogenesis; c) repeated proliferative stimuli induced by primary mitogens do not stimulate the growth of initiated cells to a focal and/or nodular stage; and d) mitogen-induced liver growth, unlike compensatory regeneration, is followed by a particular mode of cell death, namely, apoptosis.This type of cell death may be responsible for the elimi- nation of carcinogen-initiated cells.
Sane: Insane
Authors: Donald F. Klein
Journal: JAMA (1973)

<h3>To the Editor. —</h3> The misreading of our letter by D. L. Rosenhan (224:1646, 1973) calls for an answer to clarify the issue that Rosenhan's reply has only further obscured. Rosenhan stated that Rifkin et al make the same error that all the personnel... made in our study: they accept the diagnosis of schizophrenia on the slender basis of the single symptom [hallucination]. What our letter stated was that the report of a hallucination indicated that either the patient had "something wrong" or that he was malingering. We did not affirm the correctness of the specific diagnosis of schizophrenia. In fact, we stated that the diagnostic abilities of many psychiatrists warranted improvement. Nonetheless, our point was that some descriptive diagnosis should be made, whereas Rosenhan's original point seemed to be that no such diagnosis should be forthcoming. Therefore, we were very pleased to see that Rosenhan now believes that the
Rheumatic fever in Colorado. A conquered disease?
Authors: P. Rhodes
Journal: JAMA (1975)

NOT ONLY has the incidence of rheumatic fever been decreasing since 1900, but the florid manifestations have also been decreasing. Rheumatic fever is no longer a dramatic disease, and many physicians no longer consider it of much significance. But, is it a bygone, conquered disease? Officially, rheumatic fever is apparently grossly underreported in most states.<sup>1</sup>For example, in Oklahoma, eight cases of acute rheumatic fever were reported in 1969, but Silberg et al<sup>2</sup>surveyed all the Oklahoma hospitals for that year and found an overall incidence of 4.2/100,000 persons, which does not include nonhospitalized cases. Age-specific rates in the 5- to 9- and 10- to 14-year age groups were 11.3 and 14.2/100,000, respectively. <h3>Colorado</h3> The figures are equally confusing for Colorado, which has a reputation for high rates of streptococcal disease and rheumatic fever because of the high incidence in the military camps of World War II. In
Book Review Pictorial Midwifery: An atlas of midwifery for pupil midwives . By Sir Comyns Berkeley, M.A., M.C., M.D. (Cantab.), F.R.C.P. (Lond.), F.R.C.S. (Eng.), Hon. M.M.S.A., F.C.O.G. Third edition. 8°, cloth, 166 pp., with 245 illustrations. Baltimore: Williams &amp; Wilkins Co., 1939. $3.00.
Journal: New England Journal of Medicine (1940)