tbuckley/cabot-search huggingface dataset:
Impact of hemoglobin levels in psychiatric patients with cancer
Authors: E. De Marino, G. Biaggi, L. Bellan, A. M. Caprioli, G. Forti, D. Manachino, P. Camurati, P. Lozza, P. Basunti, O. Alabiso
Journal: Journal of Clinical Oncology (2004)

8233 Background: previously, we reported toxicity in a series of 26 psychiatric patients with cancer that underwent to chemotherapy (De Marino et al.; Proc. ASCO 2003). Updating our data on 27 patients,13 with haematological (H) and 14 with solid (S) tumour we observed heavy psychotic episodes in 10/27(37%)during treatments. In order to assess associations among chemotherapy related toxicities and attacks we performed the following analysis. Methods: the records of 10 patients with psychotic acute episodes were reviewed retrospectively with regards histology, sex, age, mental disorders according to standard psychiatric Diagnostic and Statistical Manual (DSM IV), haematological pattern, uprising modality and length of attacks, treatment changes. Results: Of the 10 patients, median age 69 years (range 38–85),8 males and 2 females, 7/10(70%) H: 3 Non Hodgkin's disease, 2 Multiple Myeloma,1 Myelodysplasia and 1 Chronic Myeloid Leukemia while 3/10(30%) S:2 breast,1 lung. Mental disorders were: 4 organic psychosis and dementia (F 00.10); 2 heavy recurrent depression (F.33); 3 schizophrenia (F.20); 1 personality disorder (F.21); 1 adjustment disorders (F 43.20). In 8/10(80%) patients, psychotic episodes occurred during chemotherapy (7/8 at nadir and 1/8 during bleeding) but in 2/10 patients not (progressive disease). Haematological toxicity was: neutropenia G3 in 5/10(50%), anaemia G2–3 in 10/10(100%). All were outpatients and had recovery in isolation ward during psychotic episodes and received sedatives by psychiatrist. Psychotic episodes were transient (< 3 days), became evident together with anemia (HB<9 g/dL), disappeared when haemoglobin reached at least 9.4g/dL thanks to blood transfusions. No lasting changes in psychiatric treatment were made. Conclusions: our preliminary experience indicates the possible interplay between anemia and psychotic episodes in patients with mayor mental disorders and malignancy, especially H. More patients are needed to confirm potential utility of this observation to classify correctly according to current nosologic multiaxial system. No significant financial relationships to disclose.
IRRADIATED ERGOSTEROL, VITAMIN D AND TOXISTEROL
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Second International Symposium on Cancer Detection and Prevention
Journal: JNCI Journal of the National Cancer Institute (1972)

Journal Article Second International Symposium on Cancer Detection and Prevention Get access JNCI: Journal of the National Cancer Institute, Volume 49, Issue 4, October 1972, Page 1215, https://doi.org/10.1093/jnci/49.4.1215 Published: 01 October 1972
SANARELLI'S AUTOBIOGRAPHY.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
RHINOSCLEROMA
Authors: H L WECHSLER
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Council on Medical Education and Hospitals
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Air Pollution and Blood Markers of Cardiovascular Risk
Authors: Joel Schwartz
Journal: Environmental Health Perspectives (2001)

Recent studies have linked air pollution to tens of thousands of premature cardiovascular deaths per year.The mechanisms of such associations remain unclear.In this study we examine the association between blood markers of cardiovascular risk and air pollution in a national sample of the U.S. population.Air pollution concentrations were merged to subjects in the Third National Health and Nutrition Examination Survey (NHANES III) in the United States, and the association with fibrinogen levels and counts of platelets and white blood cells were examined.The subjects in NHANES III are a representative sample of the U.S. population.Regressions controlled for age, race, sex, body mass index, current smoking, and number of cigarettes per day.The complex survey design was dealt with using mixed models with a random sampling site effect.In singlepollutant models, PM 10 (particulate matter with a mass median aerodynamic diameter less than 10 µm) was associated with all three outcomes (p < 0.05): Sulfur dioxide (SO 2 ) was significantly associated only with white cell counts, nitrogen dioxide (NO 2 ) with platelet counts and fibrinogen, and ozone with none of the outcomes.In two-pollutant models, PM 10 remained a significant predictor of white cell counts controlling for SO 2 but not vice versa.PM 10 was marginally significant in a model for platelet counts with NO 2 , and the sign of the NO 2 coefficient was reversed.These results were stable with control for indoor exposures (wood stoves, environmental tobacco smoke, gas stoves, fireplaces), dietary risk factors (saturated fat, alcohol, caffeine intake, n-3 fatty acids), and serum cholesterol.The magnitude of the effects are modest [e.g., 13 µg/dL fibrinogen for an interquartile range (IQR) change in PM 10 , 95% confidence interval (CI) 4.6-22.1 mg/dL].However, the odds ratio of being in the top 10% of fibrinogen for the same IQR change was 1.77 (95% CI 1.26-2.49).These effects provide considerable biologic plausibility to the mortality studies.PM 10 , but not gaseous air pollutants, is associated with blood markers of cardiovascular risk, and this may explain epidemiologic associations with early deaths.
Continuing Medical Education: Sofosbuvir for Hepatitis C Genotype 2 or 3 in Patients without Treatment Options
Authors: Ariel Sobarzo, E David, Julius Lutwama, Ofer Guttman, S Robert, Ana Kuehne, M John, Victoria Yavelsky, C Eli
Journal: New England Journal of Medicine (2013)

correction hemagglutinin leukoagglutinin.There were no differences in complete blood count, general medical history, or treatment during infection among persons who had been infected with Ebola virus.Results of ELISA IgG against inactivated SUDV-gul and GP 1-649 revealed that all SUDV-gul survivors tested positive for both SUDV-gul and GP 1-649 .No immunoreactivity was observed in the noninfected control group.PRNT 80 results showed that in the survivor group, four persons were positive for neutralization and two persons were negative.All serum samples obtained from noninfected persons that were not immunoreactive were negative in neutralization assays (Table 1).Survivors of Ebola virus infection had persistent serum-neutralizing activity and IgG immunoreactivity against the viral protein GP 1-649 12 years after infection, and this protein stimulated high levels of cytokine expression after whole-blood stimulation.
Impact of Clozapine on Completed Suicide
Authors: M. J. Sernyak
Journal: American Journal of Psychiatry (2001)

OBJECTIVE: Clozapine has been found to be superior to typical neuroleptics in ameliorating the symptoms of refractory schizophrenia. This study evaluated clozapine's effect on the rate of death due to suicide. METHOD: All patients over a 4-year period who initiated treatment with clozapine while hospitalized within the Department of Veterans Affairs (VA) system (N=1,415) were matched with a schizophrenic control group (N=2,830) by propensity scoring—a widely accepted statistical method that has been used relatively little in psychiatric research. Centralized VA databases and a national death registry were used to identify all deaths within the two groups, along with listed causes, for the 3 years after discharge. RESULTS: Veterans exposed to clozapine while inpatients were significantly less likely to die during the follow-up period than those in the control group, but this was entirely attributable to the much lower rate of death due to respiratory disorders in the clozapine group. There were no significant differences in rates of suicide or accidental death. CONCLUSIONS: These results fail to support the hypothesis that clozapine treatment is associated with significantly fewer deaths due to suicide.
A Report on the Biliary Secretion of the Dog: with Reference to the Action of Cholagogues
Authors: W. Rutherford
Journal: BMJ (1879)

FIRST SERIES.I.In a curarised dog that has fasted eighteen hours, the secretion of tolerably uniform during the first four or five hours after the com- mencement of the experiment, but falls slightly as a longer period elapses. Its composition remains constant.Croton-oil is a hepatic stimulant of very feeble power.The high place assigned to it by Rohrig was probably the result of his imperfect method of experiment.
ESGE Newsletter
Journal: Endoscopy (2009)

A. Abdali, AfghanistanM. Ciocirlan, RomaniaE. Craciun, RomaniaX. Garcia-Aguilera, SpainE. Ivanova, RussiaM. Kliment, Czech RepublicY-Y. Lee, MalaysiaM. Messiha, EgyptS. Rana, IndiaD. von Renteln, Germany
OCCULT FRACTURES
Authors: ROLAND HAMMOND
Journal: JAMA (1941)

This paper has been written from the point of view of the practitioner who is forced to depend on inadequate facilities for roentgen ray diagnosis. In many otherwise excellent hospitals the visiting roentgenologist attends the hospital once a week and reads all the films taken during the previous week. During his absence the physician is obliged to depend on the diagnosis of a technician or on his own judgment. We wish to emphasize the importance of the clinical examination for a suspected fracture in the face of a negative verdict by roentgen ray examination. Both examinations should be employed, but in case of doubt the clinical examination should prevail. There is need of improved education of roentgen ray technicians, better training of the practitioners in the reading of roentgenograms and more cooperation between the physician and the roentgenologist. The one surgical condition in which the roentgen ray examination as a
Surgery-Plus-Radiation Therapy Suggested for Astrocytoma
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Establishing achievable benchmarks for quality improvement in systemic therapy for early stage breast cancer.
Authors: Melanie Lynn Powis, Rinku Sutradhar, Alejandro Gonzalez, Katherine Enright, Nathan Taback, Christopher M. Booth, Maureen E. Trudeau, Monika K. Krzyzanowska
Journal: Journal of Clinical Oncology (2016)

6591 Background: Setting realistic targets for performance on quality indicators (QI) is a consistent challenge in quality improvement. Utilizing administrative data, we sought to define achievable targets for QI for systemic therapy (ST) delivery in the early stage breast cancer (EBC) population based on best performers. Methods: Deterministically linked administrative healthcare databases were used to identify EBC cases diagnosed 2006 – 2010 in Ontario, Canada. Panel of previously established QIs for systemic therapy was applied to patients who met eligibility criteria for the individual indicators. Institutions with less than 10 eligible patients for a specific indicator were excluded. An empiric benchmark was defined as the value of the indicator for which the proportion of patients meeting the indicator from institutions accounted for the top decile of eligible patients. Results: We identified 28,303 EBC patients who received surgery of which 12,252 received adjuvant chemotherapy. Benchmark results are summarized in the Table. Conclusions: Many institutions fell considerably below the benchmark. Further analysis of institution-level drivers of high quality care is required to help characterize high performing institutions. Achievable benchmarks for quality indicators. Quality Domain Indicator Achievable Benchmark (%) Range (%) Centres Meeting or Ex ceeding Benchmark Centres Underperforming Access Consult with a medical oncologist 97.1 53.5-100 10 74 Receipt of ST 50.9 19.4-68.8 8 76 ST <60 days of surgery 79 21.1-84.3 6 40 Receipt of hormonal therapy (HT) 89.2 37.5-100 7 42 Delivery Adherence to HT- Year 1 94.5 72.7-100 20 52 Surveillance imaging* 48.7 35.5-81.3 22 67 Toxicity Emergency room visits or hospi talizations post ST* 32.5 30.9-82.4 4 42 Incidence of febrile neutropenia (FN)* 4.8 0-30.3 4 42 Death <60 days from ST* <1 0-6.3 10 36 Safety Appropriate anti-emetics 100 72-100 7 29 Primary antibiotic prophylaxis for FN* 0 0-25 5 31 Secondary GCSF prophylaxis for FN 40.9 0- 41.7 2 10 Appropriate molecular testing 98.9 0-100 13 58 Inappropriate receipt of HT* 0 0-4.7 9 37 Inappropriate receipt of trastuzumab* 0 0-10 4 18 Use of CPOE for ST prescribing 100 0-100 4 42 * lower= better performance
AIDS: Politics and Science
Journal: New England Journal of Medicine (1988)

There is an aphorism sometimes used by ethicists, to the effect that "Good data make good ethics."In the context of AIDS, it is interesting to propose, for purposes of policy analysis, that "Good data make good politics."The AIDS epidemic, which first surfaced in the United States in 1981 and is already massive in its global proportions, is putting social and political skills to their most extreme test; but it is a happy fact that in just 6 short years, biomedical and epidemiologic scientists have constructed a firm foundation of data on which to build policies that are carefully crafted to fit the precise contours of the epidemic.The yields from past investment in basic research, which once seemed extravagant to some, were mercifully available when the human immmunodeficiency virus (HIV) first surfaced.The result is that, for the first time in history, humanity is in a position to respond to a major pandemic without panic and without resort to draconian extremes of social action (1).That is not what has been happening, of course, but it could happen if available knowledge were deployed wisely.Sadly, much of the AIDS dialogue these days seems to be detached from reality, much less science.The general public evades acceptance of the extent of the tragedy and instead indulges itself in superficial complaints about the tastelessness of condom advertising.Even policy makers seem to be operating on the notion that the epidemic is a finite or short-term problem: that the "good old days" will return in 1991 or soon thereafter.When 5-year projections through 1991 were made at the Coolfont meeting of the US.Public Health Service in 1986 (2), anticipating 271,000 cumulative cases of AIDS in the United States by that time, the concreteness of those numbers seems to have given some people a false impression that the worst will then be over.The projections are, in fact, unusually firm, since the long incubation period-which may be as much as 8 or 10 years between onset of HIV infection and expression of disease-means that most of the individuals included in the 5-year prediction were in fact already infected and incubating their troubles.And yet, one hears people talk as if that projected lo-fold increase in AIDS cases will not necessarily happen or, if it does, that the epidemic will magically stop there and go no further.One must dispense with such dreams quickly: AIDS is here to stay!It is like the day after Pearl Harbor in the United States-the world has changed and will never be the same again.AIDS will be a fact of life for our children's children; great efforts can be made to diminish the magnitude of the role it will play in their lives, but the virus cannot be made to disappear.The projections for 1991 might be low,
Rheumatoid disease without joint involvement
Authors: O. P. Ganda
Journal: JAMA (1974)

An elderly black man had an unusual manifestation of severe rheumatoid disease. Thus far, five years since the onset of disease, he has experienced no serious joint involvement and yet has had multiple subcutaneous rheumatoid nodules, bilateral rheumatoid pleuritis with effusion, nodular scleritis, and high titer of rheumatoid factor. (<i>JAMA</i>228:338-339, 1974)
Reversible pure red cell hypoplasia in pregnancy
Authors: G. Lehman
Journal: JAMA (1982)

PREGNANCY is normally a state of erythroid hyperplasia. Increased erythropoiesis during pregnancy is controlled by erythropoietin, which is augmented by the action of placental lactogen and inhibited by high levels of estrogen.<sup>1</sup>We describe a case of a patient with pure red cell hypoplasia during pregnancy that resolved completely in the postpartum period. <h3>Report of a Case</h3> On Jan 22, 1981, a 23-year-old primigravida came to the obstetric clinic at Naval Regional Medical Center (NRMC), Charleston, SC, for an initial prenatal visit at approximately 24 weeks' gestation. A routine hemoglobin level and hematocrit reading were noted to be 9.0 g/dL and 27.1%, respectively. Administration of ferrous sulfate, 325 mg, one tablet three times a day, was begun. A follow-up visit four weeks later revealed a hemoglobin level of 7.1 g/dL and a hematocrit reading of 24.3%. The patient denied noncompliance with respect to self-administration of the prescribed medication. The
THE MEDICAL EDITORS' ASSOCIATION.
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal