tbuckley/cabot-search huggingface dataset:
Nomograms for predicting the risk of arm lymphedema after axillary dissection in breast cancer.
Authors: J. L. B. Bevilacqua, M. W. Kattan, C. Yu, S. Koifman, I. E. Mattos, R. J. Koifman, A. Bergmann
Journal: Journal of Clinical Oncology (2011)

8 Background: Lymphedema (LE) after axillary dissection (AD) is a multifactorial, chronic, and disabling condition that currently affects an estimated 4 million people worldwide. Although several risk factors have been described, it is difficult to estimate the risk in individual patients. We therefore developed nomograms based on a large data set. Methods: Clinicopathological features were collected from a prospective cohort study of 1,054 women with unilateral breast cancer undergoing AD as part of their surgical treatment from 8/2001 to 11/2002. LE was defined as a volume difference of at least 200 mL between arms at 6 months or more after surgery. The cumulative incidence of LE was ascertained by the Kaplan-Meier method, and Cox proportional hazards models were used to predict the risk of developing LE based on the available data at each timepoint: (I) preoperatively; (II) within 6 months from surgery; and (III) 6 months or later after surgery. Results: The 5-year cumulative incidence of LE was 30.3%. Independent risk factors for LE were age, body mass index, ipsilateral arm chemotherapy infusions, level of AD, location of radiotherapy field, development of postoperative seroma, infection, and early edema. When applied to the validation set, the concordance indexes were 0.706, 0.729, and 0.736 for models I, II, and III, respectively. Conclusions: The proposed nomograms can help physicians and patients to predict the 5-year probability of LE after AD for breast cancer. Free online versions of the nomograms will be available.
Address.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Text-Book of Histology and Microscopic Anatomy of the Human Body, Including Microscopic Technic.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
To the Editor
Authors: Tito Livraghi
Journal: Hepatology (2001)

The high incidence of tumor seeding along the needle tract, reported by Llovet et al., 1 has not been reported as a complication of radiofrequency (RF) ablation of hepatocellular carcinoma (HCC) with the cooled needle in studies that date from 1996 and include several hundred patients. [2]3][4][5][6][7] It was recently reported in preliminary form only for treatment of metastases. 8 The authors did not provide a convincing explanation for the discrepancy between their data and other series.The duration of the follow-up or a lack of accurate ultrasound (US) or computed tomography (CT) monitoring cannot account for the difference, because most studies were published more than 2 years ago and the follow-up is now far longer than that of the Barcelona experience.In our center, we started performing ethanol injection in 1986, laser thermal ablation in 1997, and RF thermal ablation with the cooled needle in 1999.To date, we have used RF in 63 patients with a total of 77 nodules; the follow-up averages 16 months (range, 1-42 months).Follow-up is performed with US every 3 months and spiral CT every 6 months.Among various minor and major complications including 1 death, we never saw tumor seeding along the needle tract.The absence of this complication in our and other experiences, in contrast with the Barcelona results, is probably due to the avoidance of direct puncture of subcapsular tumors, a criterion adopted by us and by other centers.Subcapsular HCC were reported previously to give a high incidence of complications at echoguided biopsy, 9 mainly hemorrhage and hemoperitoneum, and these complications were related to the size of the needle.Some cases of seeding were also reported after fine needle biopsy 10,11 and ethanol injection 12 of subcapsular HCC.Therefore, standard practice is to avoid their puncture, particularly when the needle cannot be introduced through a layer of nontumoral liver tissue.In fact, in the 4 HCC cases of the Barcelona group that showed seeding after the procedure, the authors state that it was not possible to perform thermocoagulation when retiring the needle, a procedure that is mandatory for avoiding neoplastic seeding.We are surprised at the high percentage of subcapsular HCC treated in the series of Llovet et al. (11 out of 32 patients!),considering that these tumors are the most favorable for resection.The conclusion that we draw from this study is that puncture of subcapsular HCC (and not only for RF ablation, which utilizes large-caliber needles) entails a high risk of hemoperitoneum, may facilitate neoplastic dissemination outside the liver capsule, and should be avoided.We agree that RF ablation should be considered an experimental procedure until further studies ascertain whether it is cost effective in comparison with ethanol injection or other local-regional treatments.
Thyroid carcinoma and radiation. A Chicago endemic
Authors: L. DeGroot
Journal: JAMA (1973)

Radiation-associated thyroid carcinomas continue to occur with alarming frequency. Among 50 patients with thyroid carcinoma seen over the past four years, 20 had received prior neck x-ray treatment. These patients developed tumors an average of 20 years after x-ray exposure, and were nearly all under 35 years of age. Clinical findings were similar to those of the nonexposed carcinoma patients, but the tumors were less invasive and never undifferentiated. One patient in the x-ray group succumbed to the illness. Two thirds of our patients who have a history of known x-ray exposure and who showed clinical thyroid abnormalities had cancer. All patients who received significant x-ray exposure during childhood or adolescence should be examined for thyroid abnormalities, which may develop two or more decades after exposure.
CHAIRMAN'S ADDRESS.
Authors: M. H. FLETCHER
Journal: JAMA (1896)

I acknowledge with pleasure the courtesy shown me, in again selecting me as presiding officer; though this Section is not large as a national body, the quality of its work is second to none, and its influences are unbounded. Its tendency is to elevate to a higher standard thereby advancing the science of the profession. In looking back over the past twelve months, these marks of progress are encouragingly conspicuous and, we believe, point to a steady and healthy growth. This is indicated by the increased number of practical scientific workers who are coming forward; by books of scientific value second to none in their line; by numbers of good papers and discussions on important topics, many of which have served largely to add to our fund of knowledge. Errors have been eliminated which is equally important with new discoveries. Superstition and guessing are giving place to accuracy and precision.
THE DANGER OF SMALL-POX
Authors: C. K. Millard
Journal: BMJ (1917)

JOM 4°9 8quivocal use of tlhe word "prevention " is perhaps the source of this mnisunderstandiny.Thiere must be no confusion of attemiipts to discourage irregular sexual inter- course withi direct mnedlical measures taken to prevent venereal infectioin.While writing, tllis I lhave seen in the Lancet of to-day's date a valuabIle contributiou on the question of direct propl)ylaxis by Lieuteniant-Colonel James Barrett, R.A.M.C., C.MAi., setting fortli the views of importairt medical autlorities in Victoria, and tlherefore take the opportunity of conmending thlis paper to the notice of all who are interested in thlis discussion.
Interaction of Environmental Chemicals with the Estrogen and Progesterone Receptors from the Oviduct of the American Alligator
Authors: Peter M. Vonier, D. Andrew Crain, John A. McLachlan, Louis J. Guillette, Steven F. Arnold
Journal: Environmental Health Perspectives (1996)

Reports of reproductive abnormalities in the American alligator from Lake Apopka, Florida, have been linked to a spill of DDT and other pesticides suspected of having hormonelike activity. To determine whether environmental chemicals had the potential to function as exogenous hormones in the American alligator, we examined the ability of chemicals to bind the estrogen receptor (aER) and progesterone receptor (aPR) in a protein extract prepared from the oviduct of the alligator. In competition binding assays with [3H]17 beta-estradiol, some DDT metabolites showed inhibition of [3H]17 beta-estradiol binding to aER. A combination of DDTs demonstrated an additive decrease in [3H]17 beta-estradiol binding to aER. Modern-use chemicals such as alachlor, trans-nonachlor, endosulfan, and atrazine also competed with [3H]17 beta-estradiol for binding to the aER. To test the effect of chemicals identified in alligator eggs from Lake Apopka on [3H]17 beta-estradiol binding, we mixed these chemicals at concentrations measured in eggs in the competition binding assay. 2,2-bis(4-chlorophenyl)-N-(methoxymethyl)acetamide (p,p'-DDD) and trans-nonachlor, both found in Lake Apopka, interacted with aER, whereas others such as chlordane and toxaphene did not. Surprisingly, combinations of these chemicals decreased [3H]17 beta-estradiol binding in a greater than additive manner. To assess the ability of chemicals to interact with aPR, we performed commpetition binding assays with the synthetic progestin [3H]R5020. Most of the chemicals tested did not reduce [3H]R5020 binding to aPR, whereas endosulfan, alachlor, and kepone inhibited binding. These results provide the first evidence that environmental chemicals bind the aER and aPR from the American alligator, supporting the hypothesis that the reported reproductive abnormalities may be related to the modulation of endocrine-related responses. The findings that combinations of chemicals demonstrated a greater than additive interaction with the aER and some chemicals bind to the aPR in the competition binding assay are novel. This suggests that interactions of these chemicals with the endocrine system are complex.
A new partnership for change
Authors: J. L. Clowe
Journal: JAMA (1993)

Since antiquity, the relationship between physicians and the societies we serve has been defined by the very personal medical partnership that bonds physician to patient. At the heart of that partnership is a commitment by physicians to advocate what is best for our patients, regardless of the economic, political, or professional risk. Clearly it is time to extend the highly personal physician-patient relationship into the public policy arena. Physician-advocates must now play as direct a role in defining the health system policies of the future as they have in asserting what has been in the best medical interests of our patients in the past. In the stampede for change, we must not forget that our patients come first. This means that physicians must now reject the status quo and publicly commit to a new partnership for health system reform. The stakes are too high and our patients' well-being too important
Alteration of medical records submitted for medicolegal review
Authors: R. L. Prosser
Journal: JAMA (1992)

THE PRACTICE of altering medical records out of fear of litigation may be an increasing problem. This topic has received no recent attention in the medical literature. Physicians' alterations of research data<sup>1,2</sup>and attitudes toward changing records to improve insurance collection<sup>3,4</sup>have been reported, but no documented cases in the medical literature describe altering the records of patients who sue physicians. This review describes the medicolegal aspects of four cases involving altered patient records. The discussion following the cases focuses on some practical considerations about making additions and changes to medical records. I have practiced medicine in academic centers for 20 years. Because of my academic orientation, several state medical boards, hospitals, malpractice insurance companies, physician groups, and even a few plaintiffs attorneys have sought my opinion on cases involving pending or potential litigation. In the last 5 years, there has been a disturbing increase in the proportion
Author Correction: A dynamic COVID-19 immune signature includes associations with poor prognosis
Authors: Adam G. Laing, Anna Lorenc, Irene del Molino del Barrio, Abhishek Das, Matthew Fish, Leticia Monin, Miguel Muñoz-Ruiz, Duncan R. McKenzie, Thomas S. Hayday, Isaac Francos-Quijorna, Shraddha Kamdar, Magdalene Joseph, Daniel Davies, Richard Davis, Aislinn Jennings, Iva Zlatareva, Pierre Vantourout, Yin Wu, Vasiliki Sofra, Florencia Cano, Maria Greco, Efstathios Theodoridis, Joshua Freedman, Sarah Gee, Julie Nuo En Chan, Sarah Ryan, Eva Bugallo-Blanco, Pärt Peterson, Kai Kisand, Liis Haljasmägi, Loubna Chadli, Philippe Moingeon, Lauren Martinez, Blair Merrick, Karen Bisnauthsing, Kate Brooks, Mohammad A. A. Ibrahim, Jeremy Mason, Federico Lopez Gomez, Kola Babalola, Sultan Abdul-Jawad, John Cason, Christine Mant, Jeffrey Seow, Carl Graham, Katie J. Doores, Francesca Di Rosa, Jonathan Edgeworth, Manu Shankar-Hari, Adrian C. Hayday
Journal: Nature Medicine (2020)

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
President's Page
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Attributes of the Ideal Physician
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A NEW GASTRODUODENAL CATHETER
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Doxorubicin Administration by Continuous Infusion Is Not Cardioprotective: The Dana-Farber 91-01 Acute Lymphoblastic Leukemia Protocol
Authors: Steven E. Lipshultz, Amy L. Giantris, Stuart R. Lipsitz, Virginia Kimball Dalton, Barbara L. Asselin, Ronald D. Barr, Luis A. Clavell, Craig A. Hurwitz, Albert Moghrabi, Yvan Samson, Marshall A. Schorin, Richard D. Gelber, Stephen E. Sallan, Steven D. Colan
Journal: Journal of Clinical Oncology (2002)

PURPOSE: Acute doxorubicin-induced cardiotoxicity can be prevented in adults by continuous infusion of the drug, but mechanisms of cardiotoxicity are different in children. We compared cardiac outcomes in children receiving bolus or continuous infusion of doxorubicin. PATIENTS AND METHODS: In a randomized study, children with high-risk acute lymphoblastic leukemia received doxorubicin 360 mg/m 2 in 30-mg/m 2 doses every 3 weeks either by bolus (within 1 hour, n = 57) or by continuous infusion (over 48 hours, n = 64). Echocardiograms obtained before doxorubicin and at longest follow-up times were centrally remeasured, and z scores of cardiac measurements were calculated based on a healthy population. RESULTS: The groups were similar in age, sex distribution, doxorubicin dose, and duration of follow-up. Before treatment, measures of left ventricular (LV) structure and function did not reveal dilated cardiomyopathy and were not statistically different between bolus and continuous-infusion groups. The follow-up echocardiograms demonstrated no significant difference between the two groups for any cardiac characteristic, but both groups showed significant abnormalities of LV structure and function compared with normal and with baseline. For example, the mean LV fractional shortening fell by approximately two SD in both groups between the two echocardiograms. LV contractility was depressed in both groups (for bolus patients, median z score = −0.70 SD, P = .006; for continuous-infusion patients, median z score = −0.765, P = .005). Dilated cardiomyopathy and inadequate LV hypertrophy were noted in both groups. Clinical cardiac manifestations and event-free survival did not differ. CONCLUSION: Continuous doxorubicin infusion over 48 hours for childhood leukemia did not offer a cardioprotective advantage over bolus infusion. Both regimens were associated with progressive subclinical cardiotoxicity. Other cardioprotective strategies should be explored.
Myocarditis
Authors: Arthur M. Feldman, Dennis McNamara
Journal: New England Journal of Medicine (2000)

Myocarditis is defined clinically as inflammation of the heart muscle. First introduced into the medical literature at the beginning of the 19th century, the term “myocarditis” was initially used to describe diseases of the heart muscle not associated with valvular abnormalities.1 With the recognition of the importance of coronary-artery occlusion as a cause of heart-muscle disease at the beginning of the 20th century, the term was largely discarded. In the second half of the 20th century, a constellation of clinical observations renewed interest in inflammation of the heart muscle: myocarditis was recognized in a surprisingly large number of postmortem studies . . .
Shall The Journal be Removed to Washington?
Authors: R. Harvey Reed
Journal: JAMA (1890)

<h3>To the Editor:</h3> —In compliance with the invitation of the Trustees to discuss the resolutions referring to the removal ofThe Journalfrom Chicago to Washington, I beg leave to inquire what reasons the Committee have for making this change? This is a question which has agitated the American Medical Association more or less for years, and at one time assumed a sectional aspect, of the East<i>vs</i>. the West. The former seemed to hold to the idea that all the. brilliant minds of our profession resided in the East, and for this reason the home ofThe Journalshould be nearer the Orient. Whilst I have no reflection to cast on the brilliancy of the medical profession in the East, yet I am of the opinion that that argument will no longer hold good. It does seem to me that there are quite a number of good and