tbuckley/cabot-search huggingface dataset:
A randomized clinical trial of ursodeoxycholic acid as adjuvant treatment to prevent liver transplant rejection
Authors: D Barnes
Journal: Hepatology (1997)

Acute rejection following orthotopic liver transplantation is a common problem despite current immunosuppressive regimens. Ursodeoxycholic acid (UDCA) has been shown in small, open-labeled studies to prevent rejection episodes, although its effects on complications such as infections, length of hospital stay, and survival have not been evaluated. We conducted a randomized, placebo-controlled, double-blind trial to determine if UDCA (10-15 mg/kg/d) added to a cyclosporine-based immunosuppressive regimen was associated with a decrease in the incidence of at least one episode of acute cellular rejection. Secondary end-points included determining differences in the total number of rejection episodes, the use of muromonab-CD3, the incidence of infections, length of hospital stay, and survival at 90 days and 1 year. Fifty-two patients were randomized, 28 to the treatment group and 24 to the placebo group. During the 3 months of the trial, there was no difference between the placebo and UDCA groups in the number of patients who were rejection-free; however, there were significantly fewer patients in the treatment group who had multiple episodes of acute rejection (0 vs. 6; P = .007). Patients in the treatment group experienced a significantly lower incidence of bacterial infections (4% vs. 29%; P = .02), shorter hospital stay (25 days vs. 34 days; P = .03), and better 90-day survival (100% vs. 83%; P= .04) and 1-year survival (93% vs. 79%). The addition of UDCA to a cyclosporine-based immunosuppressive regimen results in significantly fewer patients experiencing multiple episodes of rejection and improved survival at 90 days and at 1 year. The use of UDCA as adjuvant therapy for patients undergoing liver transplantation who are treated with a cyclosporine-based immunosuppressive regimen should be considered.
Abstract LB-125: KDM5D as a novel gender-specific gene target for metastatic colorectal cancer
Authors: Jiexi Li, Zhengdao Lan, Alan Y. Wang, Ron DePinho
Journal: Cancer Research (2019)

Abstract Male colorectal cancer (CRC) patients have higher rates of incidence, mortality and poorer responsiveness to therapy compared to female patients, making it critical to identify the significant factors contributing to the gender differences and to explore gender-specific therapeutic interventions. Here, combining unbiased expression profiling and xenograft mouse model discovered the Y chromosome gene KDM5D as a male-specific pro-metastasis gene and its upregulation contributes to poorer survival in both human and mouse. Knockout of Kdm5d in male metastatic CRC cell lines aborted the liver metastasis occurrence while overexpressing Kdm5d in female primary CRC cell lines enabled their metastasis potential. Mechanistically, ChIP-seq analysis showed KDM5D primarily works as a demethylase for histone modification H3K4me2/3, downregulating metastasis-suppressing genes. KDM5D also regulates the chromosome accessibility, indicated by H3K27Ac level change and validated with ATAC-seq. Kras G12D mutation regulates Kdm5d expression and is correlated with poorer survival in male mice, which is validated in silico in human CRC data in TCGA. KDM5 family inhibitor "compound 48" showed significant power to inhibit the migration capability of human metastatic CRC cell line LoVo. This study provided a new understanding of the effect of gender on CRC and a novel gender specific therapeutic target for metastatic CRC. Citation Format: Jiexi Li, Zhengdao Lan, Alan Y. Wang, Ron DePinho. KDM5D as a novel gender-specific gene target for metastatic colorectal cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr LB-125.
In Memoriam: Philip E. Gunby, MN&amp;P Editor
Authors: M. F. Goldsmith
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 3544: High performance multiplexed targeted enrichment sequencing from FFPE tissues
Authors: Mark Consugar, Leonardo Arbiza, Kristin Butcher, Siyuan Chen, Hutson Chilton, Richard Gantt, Yehudit Hasin-Brumshtein, Jim Laugharn, Jayne Simon, Ulrich Thomann, Christina Thompson, Ramsey Zeitoun
Journal: Cancer Research (2019)

Abstract Library construction for Next-Generation Sequencing (NGS) using formalin-fixed paraffin-embedded (FFPE) samples offers unique challenges in acquiring high-quality sequencing data due to wide distribution of sample quality. Specifically, differences in formalin fixation methods lead to crosslinked and/or degraded nucleic acid and inconsistent extraction yields. Hence, FFPE extraction and library construction methods must be carefully considered for target enrichment applications. In collaboration, Covaris and Twist Bioscience demonstrate a complete library preparation and target enrichment solution that generates ready-to-sequence multiplexed libraries directly from FFPE tissue.This workflow leverages the Covaris truXTRAC FFPE total Nucleic Acid Plus Kit and oneTUBE-10 shearing with the world-class performance of Twist Bioscience’s Target Enrichment Solutions. Covaris, the Gold Standard for DNA shearing in NGS, also offers pre-analytical products that leverage Adaptive Focused Acoustics® (AFA)® technology. In this FFPE-specific application, the Covaris truXTRAC FFPE total Nucleic Acid Plus Kit and oneTUBE-10 shearing enable full emulsification of paraffin and disaggregation of tissue for highly efficient nucleic acid extraction and generation of size specific DNA libraries. With the Twist Bioscience Human Core Exome kit, the resulting libraries are indexed, pooled, and target enriched with uniquely optimized DNA probes to generate ready-to-sequence high quality multiplexed libraries.Using the aforementioned workflow, results from processing numerous FFPE tissue types are presented. Sequencing results demonstrate large improvements in general Picard metrics that include uniformity (Fold_80 &amp;lt; 1.8), sequencing depth (20X coverage &amp;gt;85% with 100X downsampling), and duplication rates (&amp;lt;6%) when compared to similar published studies. These results demonstrate a validated solution for library preparation and targeted exome sequencing of FFPE samples that can be integrated into automated workflows. The truXTRAC kit and AFA® technology from Covaris generate size specific DNA libraries from FFPE samples which, when paired with Twist Bioscience’s superior target enrichment workflow, deliver multiplexed libraries for high performance targeted sequencing. Citation Format: Mark Consugar, Leonardo Arbiza, Kristin Butcher, Siyuan Chen, Hutson Chilton, Richard Gantt, Yehudit Hasin-Brumshtein, Jim Laugharn, Jayne Simon, Ulrich Thomann, Christina Thompson, Ramsey Zeitoun. High performance multiplexed targeted enrichment sequencing from FFPE tissues [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3544.
Phase I safety study of farletuzumab, carboplatin, and pegylated liposomal doxorubicin (PLD) in subjects with platinum-sensitive epithelial ovarian cancer (EOC).
Authors: D. Jelovac, D. K. Armstrong, S. Weil, M. Phillips, B. M. Schwartz, J. M. Estes, R. D. Alvarez
Journal: Journal of Clinical Oncology (2011)

5056 Background: Farletuzumab (FAR) is a humanized monoclonal antibody that binds to the folate receptor alpha, a potentially attractive target since it is over-expressed in EOC but is largely absent in normal epithelium. A Phase I dose escalation of FAR in platinum-resistant EOC showed no dose-limiting toxicities. A Phase II study of FAR with carboplatin and paclitaxel in platinum-sensitive EOC in first relapse showed a 93% patient benefit and 20% of second remissions were longer than first remission. In a recent Phase III study in relapsed platinum-sensitive EOC, the PLD/carboplatin combination showed superiority in progression free survival compared to carboplatin/paclitaxel. The current study is being conducted to assess the safety of FAR in combination with PLD/carboplatin in women with platinum-sensitive EOC in first or second relapse. Methods: A multicenter, single-arm study enrolled 15 subjects aged 47 to 82 with platinum-sensitive EOC in first or second relapse defined by either CA-125 or Response Evaluation Criteria In Solid Tumors (RECIST) criteria between July 2010 and January 2011 for treatment with weekly FAR 2.5mg/kg in combination with carboplatin AUC 4-5 and PLD 30mg/m2 every 4 weeks for 6 cycles. Following 6 cycles of combination, maintenance treatment with weekly single agent FAR 2.5mg/kg continues until disease progression. The study’s primary objective is to assess the safety of FAR/carboplatin/PLD by standard assessment and grading using NCI CTCAEv3. Results: Preliminary safety data showed that patients tolerated treatment well. In one patient FAR administration was interrupted due to gastrointestinal toxicity. Two patients required delay in carboplatin/PLD administration due to neutropenia. Palmar-plantar erythrodysesthesia was observed in two subjects. No cardiac toxicity was appreciated with FAR/carboplatin/PLD treatment. No severe adverse events have been documented and all subject remain on study to date. Conclusions: These preliminary safety data indicate that combination of FAR, carboplatin and PLD is well tolerated. Complete safety profile will be assessed and final results will be presented.
From the editors
Authors: Louisa Flintoft, Tanita Casci, Mary Muers, Darren Burgess, Matthew Smyllie, Yukie Ozawa, Catriona Rodwell, Man Tse, Lucie Wootton, Lewis Packwood, Patrick Morgan, Susanne Harris, Vicky Summersby, Kirsten Managing, Judith Shadwell, Simon Fenwick, Natalie Smith, Laura Corns, Deborah Anthony, Marketing Managers, Tim Redding, Leah Rodriguez, Laura Firman, James Butcher Managing, Philip Campbell, Jenny Henderson, Dominic Pettit, James Mcquat, Yvonne Strong, Dan Pollock, Alexander Thurrell, Anthony Barrera, Luigi Squillante, Dean Sanderson, Sara Girard, Antoine Bocquet Manager, Koichi Nakamura, Asia-Pacific Sales, Kate Yoneyama, Marketing Manager, Peter Yoshihara Marketing, Takesh Murakami, Harpal Gill
Journal: Nature Reviews Genetics (2011)
Three mile island. The silent disaster
Authors: J. S. Smith
Journal: JAMA (1981)

From Wednesday, March 28, 1979, to Wednesday, April 4, 1979, Dauphin County, Pennsylvania, was in a state of near-panic in response to the Three Mile Island nuclear accident. The Dauphin County Office of Emergency Preparedness quickly attempted to develop a plan to evacuate not only the population of an area 20 miles in radius from the plant but the short-term and long-term care medical facilities as well. For medical evacuation, a system of classification of patients was defined and matched to needed transportation. Furthermore, a critical coordinating link was established with the Hospital Association of Pennsylvania to identify and categorize relocation beds in receiving hospitals far from the incident site in the event of evacuation. Just as this incident was unusual, so too were the planning activities unique since they were never before conceived or accomplished. (<i>JAMA</i>1981;245:1656-1659)
Mucocutaneous lymph node syndrome. A case masquerading as Rocky Mountain spotted fever
Authors: P. S. Bergeson
Journal: JAMA (1977)

Mucocutaneous lymph node syndrome is a recently described entity whose principal signs and symptoms include fever, unresponsiveness to antibiotics, congested conjunctivae, reddening of the oral cavity, lips, palms, and soles, exanthem, edema, nonsuppurative cervical adenitis, and desquamation of the fingertips. Almost 7,000 cases have been reported in Japan. Analysis of the 39 cases reported in the United States reveals findings similar to those in Japan. United States cases, however, have had a higher boyto-girl ratio (2:1), and age distribution peaks at a later time (3 years of age). We report a case with many characteristics of Rocky Mountain spotted fever, including a positive Weil-Felix reaction. Some cases of mucocutaneous lymph node syndrome may be misdiagnosed as Rocky Mountain spotted fever. (<i>JAMA</i>237:2299-2302, 1977)
The Croonian Lectures on the Relationship between Chemical Structure and Physiological Action
Authors: T. L. Brunton
Journal: BMJ (1889)

ELEMENTS AND RADICALS.Atoms and Molecules.-Intheir chemical relations these sub- stances-acetylene, ethylene, methane, benzene, and furfuran-are practically elements formed at a low temperature, and may be fitly compared with the alkaline metals and those of the alkaline earths which, if Lockyer's hypothesis be right, have formed at enormously high temperatures.In describing this hypothesis I spoke of single atoms of elementary matter, or protyle, as Crookes calls it, as having been existent at first, but under the conditions which now prevail single atoms, with one or two exceptions, seem incapable of independent existence, and a molecule is the smallest quantity capable of such existence.Atoms are supposed either to join together with atoms of a like nature to form a molecule of an element, or with atoms of another element to form the molecule of a compound.When the molecule of an element is split up into single atoms, as, for example, the molecule of Diagram to show relation of differentiation with affinity for (A) Acid (B) Basic Aniline Dyes, Aniline Dyes. MostSemi-Nucleo
Caring for the uninsured. Choices for reform
Authors: R. J. Blendon
Journal: JAMA (1991)

These recent events provide the impetus for this theme issue ofThe Journal: (1) Government reports show a 24% increase in the last decade in the total number of uninsured people and a 40% increase in the number of uninsured children.<sup>1-4</sup>Most uninsured children are part of a family with a working adult. (2) Recent studies have found that, despite considerable amounts of uncompensated care provided by hospitals and physicians, Americans without health insurance face major barriers to the receipt of needed health services. Although they suffer from higher rates of ill health than the insured population, the uninsured report fewer hospitalizations and fewer visits to a physician, shorter hospital stays, and fewer discretionary inpatient hospital treatments and tests, at higher cost. The uninsured also experience higher mortality rates when hospitalized than persons with health insurance coverage who have similar medical diagnoses.<sup>5-11</sup>(3) There is evidence of growing
Emergency Medicine: Concepts and Clinical Practice
Authors: Richard O. Cummins
Journal: JAMA (1988)

A reader gets an overwhelming sense when reading this book that the authors have been there. Dr Rosen and his coeditors have continued the approach so welcomed in their first edition in 1983 of selecting only practicing emergency physicians as contributors. This produces a work that appeals to the "urban cowboy" syndrome in emergency medicine—the ED doc (emergency department physician) as the person of experience, practicality, and clinical acumen, attuned to the subtleties of patient behavior, possessing a slight patina of cynicism but with an underlying warmth, humanity, and a cheerful sense of rising to the challenge of whatever comes through the ED doors. The ED doc is unencumbered by the compulsive, overly sophisticated work-ups required "upstairs." Instead, he or she asks first, "How much time do I have to act, and how much to think?... Left unattended, how soon will this patient die?" The ED physician must face and
Bertram Mann
Journal: BMJ (2004)

An icon in the treatment of Lassa feverIn early 2000 Dr Bill Aldis, then the World Health Organization's representative in Sierra Leone, remembers getting a worried call from Geneva: "I've got an ICRC [International Committee of the Red Cross] staff member with suspected Lassa fever just evacuated from Kenema [in Sierra Leone].What do I do?" Dr Aldis replied, "The best thing you could do is put him on an airplane and get him back to Kenema-there's a hospital there with the world's greatest expert in Lassa fever, a guy named Conteh . .."Such was the reputation of Aniru Conteh, who ran the world's only Lassa fever isolation ward.Born in 1942 in Jawi Folu, Eastern Province, Sierra Leone, Aniru Conteh was the son of the local chief.At the age of 16 he left home to go to school in the country's capital, Freetown, where he went on to study chemistry and biology at Fourah Bay College.Initially he worked as a teacher, but in 1974 he enrolled as a medical student at the University of Ibadan in Nigeria, where he continued to work after qualifying, until he returned to Sierra Leone in 1979 and started working on the Lassa fever programme.Lassa fever takes its name from a small village in Nigeria, where a mysterious outbreak in a mission hospital in 1969 led to the three mission nurses becoming infected.Two of the nurses died, but the third survived and was evacuated to the Colombia Presbyterian Hospital in New York.Wilbur
Ionic calcium determination in primary hyperparathyroidism
Authors: J. C. Low
Journal: JAMA (1973)

Serum ionic and total calcium levels were measured in 15 patients with clinical diagnosis of primary hyperparathyroidism. Ionic calcium level was measured by a calcium-selective liquid-membrane electrode and total calcium level was measured by atomic absorption spectroscopy. Concurrent determinations of ionic and total calcium in 230 blood donors served as normal values. Of the determinations of ionic calcium in the hyperparathyroid patients, 98.5% (67 of 68) fell outside the normal range of 4.48 to 5.28 mg/100 ml, while 77% (57 of 74) of the determinations of total calcium in the same patients was outside the normal range of 8.3 to 10.1 mg/100 ml. Parathyroid adenomas or hyperplasia were found in 14 of 15 patients. The calcium-selective electrode has proven to be highly discriminatory in separating hypercalcemia from normocalcemia in patients with primary hyperparathyroidism.
Physicians May Play An Important Role In Suicide Prevention
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Human Biology
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Chickenpox can still kill adults
Journal: BMJ (2001)

Chickenpox can still kill adultsMore than four fifths of deaths from chickenpox are now in adults, compared with less than half 30 years ago.Chickenpox accounts for about 25 deaths annually in England and Wales, more than from measles, mumps, pertussis, and Hib meningitis combined.Deaths are twice as common in men as in women.Rawson and colleagues (p 1091) draw attention to the importance of chickenpox as a cause of death by examining 119 death certificates that mentioned chickenpox in England and Wales over a three year period.Chickenpox should therefore not be thought of as a innocuous disease.
Table Data Errors in: Effects of Exercise Training on Depressive Symptoms in Patients With Chronic Heart Failure: The HF-Action Randomized Trial
Authors: Connie Chen, Sanket Dhruva, Rita Redberg, Redberg Chen, Dhruva Chen, Redberg Dhruva
Journal: JAMA (2012)

Effects of Exercise Training on Depressive Symptoms in Patients With Chronic Heart Failure: The HF-ACTION Randomized Trial