tbuckley/cabot-search huggingface dataset:
Chronic mucocutaneous candidiasis, myositis, and thymoma. A new triad
Authors: L. F. Montes
Journal: JAMA (1972)

Another patient, to our knowledge the third reported in the literature, had a triad composed of intractable, chronic, mucocutaneous candidiasis, myositis, and thymoma. This is the second instance in which a thymoma was found and removed surgically following development of the two clinically more evident members of the triad. Myositis was the first manifestation, preceding the onset of candidiasis by 11 years. Results of a muscle biopsy revealed interstitial lymphorrhagia in a perivascular location. Light and electron microscopic study of the tumor demonstrated numerous small and large lymphocytes, as well as some larger epitheliallike cells resembling closely the earliest differentiating stages of thymic myoid cells. The fungal infection showed minimal spontaneous improvement during the first year after surgery.
Use of medical record linkage to study readmission rates.
Journal: BMJ (1989)

cross the blood-brain barrier and may be given by inhalation.5 6In the few asthmatic patients whose symptoms are worsened by non-steroidal anti-inflammatory drugs (those sensitive to aspirin) we recommend using paracetamol for mild analgesia; for more severe analgesia opiates are not contraindicated provided that asthma is adequately controlled.
Cardiac morbidity and related mortality in children with HIV infection
Authors: L. M. Luginbuhl
Journal: JAMA (1993)

<h3>Objective.</h3> —Dysrhythmias, hemodynamic instability, congestive heart failure, and sudden death are serious complications of human immunodeficiency virus (HIV) infection that, to our knowledge, have not been studied systematically. We sought to determine the cumulative incidence and clinical predictors of these adverse events in a cohort of HIV-infected children. <h3>Design.</h3> —Historical cohort study. <h3>Setting.</h3> —University-affiliated, primary and tertiary care pediatric hospital and ambulatory care center. <h3>Participants.</h3> —Eighty-one HIV-infected children who had one or more cardiac evaluations between 1984 and 1991 form the study cohort. The initial cardiac evaluation occurred at a median age of 1.5 years, and children were followed up to a median age of 3.6 years. <h3>Main Outcome Measures.</h3> —Mortality (related to cardiac dysfunction as well as noncardiac causes), tachycardia, bradycardia, hypertension, hypotension, marked sinus arrhythmia, cardiac arrest, and chronic congestive heart failure. <h3>Results.</h3> —Hemodynamic abnormalities and dysrhythmias occurred frequently. Eight unexpected cardiorespiratory arrests occurred in seven children (9%). Chronic congestive heart failure was noted in 10% of patients. Thirty children died, 10 with significant cardiac dysfunction. As HIV-infected children progressed from acquired immunodeficiency syndrome (AIDS)—related complex to AIDS, significant cardiac problems were more likely to occur. Both nonneurologic AIDS and encephalopathy were strongly associated with most severe cardiac outcomes. However, encephalopathy was the strongest correlate of cardiorespiratory arrest (<i>P</i>=.002). Epstein-Barr virus coinfection was the strongest correlate of chronic congestive heart failure (<i>P</i>&lt;.001). <h3>Conclusions.</h3> —Cardiac morbidity and mortality are more common with advanced HIV infection. The presence of encephalopathy or Epstein-Barr virus coinfection identifies HIV-infected children at especially high risk for adverse cardiac outcomes. (<i>JAMA</i>. 1993;269:2869-2875)
Measuring science
Authors: Zameer Shah
Journal: BMJ (2004)

<h3>Abstract</h3> <b>Objective</b> To determine, through the use of molecular diagnostic tools, whether the two species of parasite that cause human African trypanosomiasis have become sympatric. <b>Design</b> Blood sampling of all available patients between June 2001 and June 2005 in central Uganda and between July and September 2003 in northwest Uganda and analysis of subcounty sleeping sickness records in Uganda between 1985 and 2005. <b>Setting</b> Sleeping sickness treatment centres in central and northwest Uganda and in south Sudan. <b>Participants</b> Patients presenting at the treatment centres and diagnosed as having sleeping sickness. <b>Main outcome measure</b> Classification of parasites from patients from each disease focus as either <i>Trypanosoma brucei rhodesiense</i> (acute form) or <i>T b gambiense</i> (chronic form). <b>Results</b> Blood from 231 patients with sleeping sickness in central Uganda and from 91 patients with sleeping sickness in northwest Uganda and south Sudan were screened for <i>T b rhodesiense</i> (detection of SRA gene) and <i>T b gambiense</i> (detection of TgsGP gene). All samples from central Uganda were classified as <i>T b rhodesiense</i>, and all samples from northwest Uganda and south Sudan were identified as <i>T b gambiense</i>. <b>Conclusions</b> The two focuses of human African trypanosomiasis remain discrete, but the area of Uganda affected by the acute form of human sleeping sickness has increased 2.5-fold since 1985, spreading to three new districts within the past five years through movement of infected livestock. Without preventive action targeted at the livestock reservoir of this zoonotic disease, it is likely that the two disease focuses will converge. This will have a major impact on diagnosis and treatment of this neglected disease. Real time monitoring is recommended, using molecular diagnostic tools (at a regional surveillance centre, for example) targeted at both livestock and human patients.
Anthrax
Journal: JAMA (2000)

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Some Curious Proper Names.
Authors: None G. H. S.
Journal: JAMA (1896)

<h3>CHICAGO AS AN ANATOMIC AND PHYSIOLOGIC ENTITY.</h3> Chicago, Jan. 1896. <h3>To the Editor:</h3> —Some time ago while looking through the 1894 Chicago Directory for the residence of a slow-paying patient we became impressed with the remarkable number of anatomic and physiologic terms made use of by the Human family to distinguish each other, and the idea occurred to us of Making Man in a Shape, Size, Weight and Motion similar to ours from the parts thus obtained. It will be observed that it required no inventive Genius, for the process was purely synthetic. With a Model before us and not being limited to Dust or Mudd, we took a Bone, and then finding any number of Bones, we decided upon having a Full compliment of Ribbe's rather than leave a Ribout. Having thus obtained a Skeleton our next step was to add Joints and Marrow. Looking about us we were
THE EARLY DIAGNOSIS OF CARCINOMA OF THE STOMACH, WITH THE BACTERIOLOGY OF THE STOMACH CONTENTS.
Authors: FENTON B. TURCK
Journal: JAMA (1895)

After the study of sixteen cases Rosenheim (<i>Berl. Klin. Woch.</i>, Dec. 24, 1888) concluded that the chemic insufficiency of the stomach in carcinoma ventriculi is not due to the cancer itself, but to the attending atrophy. He divided the pathologic changes into three stages: inflammatory, interstitial and atrophic; adding that these stages may be present at the same time; and Ewald (<i>Berl. Klin. Woch.</i>, Dec. 3, 1888) holds that the disappearance of HCl is not due to carcinoma directly, but is merely a disturbance of the functions of the secretory glands. The post-mortem changes often veil the pathologic changes, unless well marked and permanent lesions occur. It is best, if possible, to secure specimens during an operation for carcinoma of the stomach as far remote from the tumor as possible. In three operations I secured several sections—one for carcinoma planum (anterior wall) where a large area was removed, leaving a border
In Vitro Dissolution of Curium Oxide Using a Phagolysosomal Simulant Solvent System
Authors: Suzanne Y. Helfinstine, Raymond A. Guilmette, Gerald A. Schlapper
Journal: Environmental Health Perspectives (1992)

Detailed study of actinide oxide behavior in alveolar macrophages (AM) in vitro is limited because of the short life span of these cells in culture. We created an in vitro dissolution system that could mimic the acidic phagolysosomal environment for the actinide and be maintained for an indefinite period so that dissolution of more insoluble materials could be measured. The dissolution system for this investigation, consisting of nine different solutions of HCl and the chelating agent diethylenetriamine pentaacetate (DTPA) in distilled water, is called the phagolysosomal simulant solvent (PSS). In this system, both the pH and the amount of DTPA were varied. We could observe the effect of altering pH within a range of 4.0-6.0 (similar to that of the phagolysosome) and the effect of the molar ratio of DTPA to curium at 1000:1, 100:1, or 10:1. We chose curium sequioxide (244Cm2O3) to validate the PSS for actinide dissolution versus that occurring in AM in vitro because it dissolves significantly in less than 1 week. The polydisperse 244Cm2O3) aerosol was generated, collected on filters, resuspended, and added to the PSS solutions and to cultured canine AM. By comparing dissolution in the two systems directly, we hoped to arrive at an optimum PSS for future dissolution studies. PSS and cell culture samples were taken daily for 7 days after exposure and tested for the solubilized curium. The amount of soluble material was determined by ultracentrifugation to separate the insoluble Cm2O3 from the soluble curium in the PSS solutions and filtration for the cell-containing material.(ABSTRACT TRUNCATED AT 250 WORDS)
Hyperparathyroid and Hypoparathyroid Disorders
Authors: Daniel Cardinali
Journal: New England Journal of Medicine (2001)

The New Eng land Jour nal of Medicine reviewed behaviorally conditioned suppression of the immune system and provided strong support for the integration of the "somatic" and "psychological" aspects of immunity.The table of contents of the third edition of Psychoneuroimmunology is an indication of the depth and breadth of its subject matter.Molecular biology, genetics, the neurosciences, immunology, cell biology, endocrinology, chronobiology, pharmacology, anatomy, biochemistry, and the behavioral sciences are considered.This list demonstrates that psychoneuroimmunology constitutes a meeting ground for medicine, biochemistry, genetics, psychology, and human ethology.It emphasizes the indivisibility of somatic and psychological processes and the inseparability of immunologic and neuroendocrine processes.The first three parts of Psychoneuroimmunology deal with the pathways that bridge the brain and the immune system -namely, the neuroendocrine and autonomic nervous systems.The primary and secondary lymphoid organs are sympathetically and parasympathetically innervated, and these types of nerve fibers form neuroeffector junctions with the lymphocytes, monocytes, macrophages, and granulocytes that possess the appropriate receptors.Several chapters in the book cover the ways in which neural and neuroendocrine signals modify immune processes and the ways in which cytokines affect brain function.One of the most valuable chapters deals with how sleep influences the homeostatic regulation of the immune system.Sleep deprivation, for example, adversely affects resistance to infectious diseases.Most of the mechanisms underlying the relation between sleep and modulation of the immune system are unknown, but it seems clear that these mechanisms are important in host defenses.Parts IV and V of Psychoneuroimmunology document the effects of behavior and stress on immune function.Important topics, such as pain and the effects of early rearing experiences and social interactions, are covered.Psychoneuroimmunology ends with chapters, in part VI, devoted to the links between psychoneuroimmunology and neurologic and psychiatric diseases, infection, surgical trauma, cardiovascular disease, periodontal disease, alcoholism, and aging.These contributions discuss the influence of emotions on immune responsiveness and the ways in which personal and social support can help in the recovery from an immunemediated disease.Reading this book leaves the impression that research in psychoneuroimmunology is growing exponentially.The third edition of Psychoneuroimmunology contributes substantially to this effort.
Error in Order of Authors in Byline
Authors: Jesper Lagergren, Giola Santoni, Nora Disis, Lee Ellis
Journal: JAMA Oncology (2019)

Unfortunately, we realized after publication that there was a major problem with the analysis in our study.One of our group's statisticians, who was not an author of this article, recently started analyzing the risk of pharyngeal and laryngeal cancer in the same cohort and identified a problem with the original statistical analyses of the follow-up categories after antireflux surgery and medication.For each follow-up category, only those people with the total study time within the category were kept in the analysis.If an individual was included, the individual's entire follow-up was used for the calculations.This led to 2 problems: in earlier follow-up categories, the person-years were underestimated, and in later follow-up categories, the person-years were overestimated.Therefore, the entire study has been reanalyzed.Unfortunately, these errors led to incorrect reporting of standardized incidence ratios (SIRs) of the follow-up categories in the study, and the reported pattern of a decreased risk of esophageal adenocarcinoma over time after antireflux surgery and medication is incorrect.Instead, no decrease was found after the correct analyses were conducted.The same mistake was present in the Cox regression analysis, but because both exposed and nonexposed were treated in the same way, the resulting hazard ratios are similar to those initially reported.Finally, some minor corrections of the cohort members led to some small differences in the numbers in the cohort, but these did not change the results.However, the study's conclusion changes significantly and in a clinically important manner to the following: "Medical and surgical treatment of GERD were not associated with any reduced esophageal adenocarcinoma risk, compared with the background population over time, indicating that treatment of GERD might not prevent esophageal adenocarcinoma."Thus,
Site of latent herpes.
Journal: BMJ (1973)

accepted, and some workers6 13 14 consider that such patients may safely take small quantities of salicylates.At present the balance of evidence still leads to the conclusion that excessive consumption of phenacetin is the principal factor in the development of analgesic nephro- pathy.This is not to deny that other factors, including the consumption of other analgesics, the presence of impurities in the phenacetin,15 individual variation in the metabolism of phenacetin,16 episodes of dehydration,3 17 and renal infec- tiofl8 might all be important in potentiating this effect.
MEDIAL PROGRESS.
Journal: JAMA (1890)

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Ten-Day Decitabine with Venetoclax Versus Intensive Chemotherapy in Relapsed or Refractory Acute Myeloid Leukemia: A Propensity Score Matched Analysis
Authors: Abhishek Maiti, Courtney D. DiNardo, Tapan M. Kadia, Elias Jabbour, Caitlin R. Rausch, Naval Daver, Gautam Borthakur, Naveen Pemmaraju, Nicholas J. Short, Musa Yilmaz, Yesid Alvarado, Kathryn S Montalbano, Allison Wade, Rita Maduike, Julio A Guerrero, Kenneth Vaughan, Carol A. Bivins, Sherry A. Pierce, Farhad Ravandi, Hagop M. Kantarjian, Marina Konopleva
Journal: Blood (2020)
Phosphoribosyltransferase deficiency gout
Journal: JAMA (1969)

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"IMPEACHING" A HEALTH COMMISSIONER.
Journal: JAMA (1894)

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JAMA Psychiatry
Authors: Phil Fontanarosa, Annette Flanagin, Paula Glitman, Brenda Gregoline, Tracy Frey, Shannon Sparenga, Miriam Cintron, Paul Ruich, Diane Cannon, Vickey Golden, Connie Manno, Laura Copyreaders, Catherine Adamcyzk, Jan Alden, Mary Clavey, Cheryl Coerver-Connolly, Gillian Davidow, Laura Dickens, Juliann King, Donna Tarsney, Caroline Thordsen, Wanda Assistant, Larry Bryant, Monica Mungle, Elaine Managers, Sta Gardner- Gullens, Helene Biernacki, Fanny Brown, Paul Frank, Rachell Lozano, Michaela Mark, J Ne, Kate Pezalla, Saulsberry Gale, Michael Berkwits, Design Michelle, Kurzynski Sta, Eric Butkus, Christopher Hastings, Craig Mcca Rey, Reuben Rios, Ronna Henry, Sta Bird, Alison Burke, Cassio Lynm, David Song, Deputy Livingston, Thomas Cole, Marla Sta, Deanna Willis, Yolanda Davis, Joseph Thornton, Jann Sta, Deanna Bellandi, Jim Periodical, Thomas Easley, Sta Smith, J Bonistalli Manager, Kathy Sta, Mirna Monal, Tim Classi, Thalia Sta, Tem Harrier, Susan Henning, Marketing Mark, Thornbury Sta, Tricia Castellano, Saskia Bolore, Gretchen Linder, Brian Mccartney Sta, Rebecca Haas, Christine Hearne, Irma Lara, Audra Lawlor, Scott Marketing, Matt Herron, Elizabeth Solaro, Geo Development, Rick Bell, Paul Gee, Michael Mcgraw, Sara Nagy, Stacy Tucker, Sta Millette, Karen Adams-Taylor, Karl Elvin, Sue Sherrill, Brian Shields Managers, David Antos, Chris Borden, Debbie Camp, Lydia Cruz, Diane Darnell, Colleen Kelly, Chris Meyer, Emily Mitchell, Jaye Mize, Sean O'donnell, Sean Ohlson, Phil O'leary, Ryan Patella, Susan Price, Denise Steinhauser, Production Services, Kim Boler, Rhonda Brown, Timothy Burke, Susan Chiara, Daniel Degroot, Jordynn Farrar, Euwanaha Joiner-Smith, Cindy Rendlen, Ellen Yoshihara, Circulation Services, Julie Burton, Dexter Golden, Erin Hinchcli, Noemi Rivera, Geneine Van, Someren Composition, New Media, Gail Barrett, Regina Brownlee, Brenda Chandler-Grayer, Scott Curl, Amy Evers, Teri Hutchison, Mary Kuranda, Joshua Lampinen, Fred Marshall, Patricia Panek, La Son, Diggs Sledge, George Thomson Graphics, Joe Amft, Maria Duda, Fred Furtner, Carolyn Hall, Maria Kowalkowski, Proofreading Carol, Joy Farrell, Daniel James, Judith Literskis, Teresa Omiotek, James Madara, Bernard Hengesbaugh, Dost Öngür, Peter Siekmeier, Michael Miller, Newton Centre, Deborah Johnson, Howard Bauchner, Joseph Coyle
Journal: JAMA Psychiatry (2013)
Medical Education and Registration; United States and Canada.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal