Guanabenz Overdose
Authors: ALAN H. HALL
Journal: Annals of Internal Medicine (1985)

Brief Reports1 June 1985Guanabenz OverdoseALAN H. HALL, M.D., SUSAN C. SMOLINSKE, B.S., R.Ph., KENNETH W. KULIG, M.D., BARRY H. RUMACK, M.D.ALAN H. HALL, M.D., SUSAN C. SMOLINSKE, B.S., R.Ph., KENNETH W. KULIG, M.D., BARRY H. RUMACK, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-102-6-787 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptGuanabenz (2,6-dichlorobenzylidene aminoguanidine acetate; Wytensin; Wyeth Laboratories, Philadelphia, Pennsylvania) is a centrally acting, selective, alpha2-adrenergic agonist combining the substituted benzene ring of clonidine with the aminoguanidine sidechain of guanethidine (1). The hypotensive and bradycardic effects of this new antihypertensive agent are mediated by stimulation of postsynaptic inhibitory receptors in the central nervous system, which results in decreased peripheral sympathetic tone (1). Therapeutic doses range from 8 to 96 mg/d for adults and 3 to 13 mg/d for children (2, 3). Experience with guanabenz overdose is limited. Animal studies of overdose have shown sedation, cardiac depression, ataxia, hyperglycemia, and hypothermia (1)....References1. BAUMSHROPSHIREROWLES TAG. General pharmacologic actions of the antihypertensive agent 2,6-dichlorobenzylidene aminoguanidine acetate (WY-86789). J Pharmacol Exp Ther. 1970;171:276-87. MedlineGoogle Scholar2. WALKERDEITCHSCHNEIDERHAREGOLD BMBLJ. Long-term therapy of hypertension with guanabenz. Clin Ther. 1981;4:217-28. MedlineGoogle Scholar3. WALSONRATHKILBOURNEDEITCH PAKM. Guanabenz for adolescent hypertension. Pediatr Pharmacol (NY). 1984;4:1-6. MedlineGoogle Scholar4. MEACHAMEMMETTKYRIAKOPOULOS RMA. Disposition of 14C-guanabenz in patients with essential hypertension. Clin Pharmacol Ther. 1980;27:44-52. CrossrefMedlineGoogle Scholar5. WINERCARTER NC. Effects of abrupt discontinuation of guanabenz and clonidine in hypertensive patients. Clin Pharmacol Ther. 1983;31:282-3. Google Scholar6. MCMAHONCOLEBOYLESVANOV FPPS. Study of a new antihypertensive (guanabenz). Curr Ther Res. 1974;16:389-97. MedlineGoogle Scholar7. ANDERSONHARTCRUMPLERLERMAN RGCM. Clonidine overdose: report of six cases and review of the literature. Ann Emerg Med. 1981;10:107-12. CrossrefMedlineGoogle Scholar8. ARTMANBOERTH MR. Clonidine poisoning: a complex problem. Am J Dis Child. 1983;137:171-4. CrossrefMedlineGoogle Scholar9. BANNERLUNDCLAWSON WML. Failure of naloxone to reverse clonidine toxic effect. Am J Dis Child. 1983;137:1170-1. MedlineGoogle Scholar10. KULIGDUFFYRUMACKMAUROGAYLORD KJBRM. Naloxone for treatment of clonidine overdose [Letter]. JAMA. 1982;247:1697. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rocky Mountain Poison and Drug Center Denver, Colorado PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByLC-MS/MS determination of guanabenz E/Z isomers and its application to in vitro and in vivo DMPK profiling studiesThe split protein phosphatase systemPrion Properties of SOD1 in Amyotrophic Lateral Sclerosis and Potential TherapyDecoding the selectivity of eIF2α holophosphatases and PPP1R15A inhibitorsGuanabenz Sensitizes Pancreatic β Cells to Lipotoxic Endoplasmic Reticulum Stress and ApoptosisIntegrated Stress Response as a Therapeutic Target for CNS InjuriesPreventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunitSurviving protein quality control catastrophes – from cells to organismsClonidine and Related Imidazoline DerivativesOther Cardioactive AgentsGuanabenz Acetate 23256-50-0Guanabenz Induced Hypothermia in a Poisoned Elderly FemaleGabexatAntihypertensive drugsGuanabenz OverdoseSUSAN J. ROGERS, Pharm.D. 1 June 1985Volume 102, Issue 6Page: 787-788KeywordsAddictionAtaxiaCentral nervous systemChildrenHyperglycemiaHypothermiaSedationSympathetic nervous system Issue Published: 1 June 1985 PDF DownloadLoading ...