tbuckley/cabot-search huggingface dataset:
Pathomorphological study of Kupffer cells in hepatocellular carcinoma and hyperplastic nodular lesions in the liver
Authors: M Tanaka, O Nakashima, Y Wada, M Kage, M Kojiro
Journal: Hepatology (1996)

A pathomorphological study was conducted to clarify the localization of Kupffer cells in hepatocellular carcinoma (HCC) tissues and such hyperplastic nodular lesions as adenomatous hyperplasia (AH) and focal nodular hyperplasia (FNH). Materials were surgical specimens of 50 HCCs, 7 AHs, and 13 FNHs. These tissues were immunohistochemically stained with an anti–human macrophage antibody (anti–CD68 antibody). Among CD68–positive cells, short spindle–shaped cells were considered as Kupffer cells, and Kupffer cell numbers in tumor lesions and surrounding liver tissues of each specimen were comparatively examined. As a result, the number of Kupffer cells in well–differentiated HCC tissues less than 1 cm in diameter was 27.8 ± 3.3 (mean ± SE/0.25 mm2); in noncancerous tissues, it was 30.2 ± 3.2, showing no statistically significant differences. The number of Kupffer cells in cancerous tissues decreased in comparison with the number in noncancerous tissues, as the tumor size increased and histological grade decreased. In hyperplastic nodular lesions, the number was higher in nodular lesions than in the surrounding liver tissues in 4 of 7 AHs (57.1%) and 6 of 13 FNHs (46.2%). This could explain the reason why enhanced MRI, which utilizes the selective taken–up mechanism of chondroitin sulfate iron colloid and superparamagnetic iron oxide into the reticuloendothelial system of the liver and spleen, depicts well– differentiated HCC and AH at the same signal intensity as in the surrounding liver tissues. Our findings also indicate that there is a limitation in differentiating or diagnosing small HCC and hyperplastic nodular lesions by using enhanced MRI, which utilizes Kupffer cell functions.
Results from 8 yrs of susceptibility testing of clinical Mycobacterium tuberculosis isolates in Denmark
Authors: VO Thomsen, J Bauer, T Lillebaek, S Glismann
Journal: European Respiratory Journal (2000)

Increased rates of multidrug-resistant (MDR) tuberculosis (TB) has been reported from countries close to Denmark. This study evaluated the incidence of drug resistance in Denmark in order to determine the magnitude of the problem. Susceptibility testing was performed in isolates from 85.4% of all notified patients during 1991-1998. Epidemiological information was retrieved from the mandatory notification forms. Total drug resistance remained largely constant, although a minor increase was observed in 1997-1998. Monoresistance was observed in 7.3%, of the isolates. Among 3.6% polyresistant isolates, resistance to isoniazid and streptomycin accounted for 2.8%, whereas MDR accounted for 0.5%. The MDR strains displayed different restriction fragment length polymorphism (RFLP) patterns, and no matches were identified in the international MDR database. Drug resistance in untreated Danes and foreigners were 5.9% and 14.6%, respectively. Among Danes and foreigners with previous TB, 6.2% and 22.7% had drug resistance, respectively. Increased drug-resistance was found among untreated Danes aged 25-54 yrs mainly due to a single isoniazid and streptomycin-resistant RFLP-cluster. Among all patients with isoniazid and streptomycin-resistance, 77.0% had clustered strains. In conclusion, although drug resistance among untreated Danes was close to the rate estimated in good national programmes, close monitoring is needed in future years, as active transmission of isoniazid- and streptomycin-resistant Mycobacterium tuberculosis was demonstrated.
Adverse reactions associated with ticrynafen use
Authors: D. A. McLain
Journal: JAMA (1980)

Three hypertensive patients receiving ticrynafen, a new uricosuric diuretic, experienced adverse reactions. One patient experienced acute renal failure, the second experienced a renal stone, and the third had a fatal hemorrhage while receiving anticoagulation therapy with warfarin sodium. All complications can be explained by known actions of the drug and are preventable. However, these reactions illustrate the potential hazards from widespread substitution of ticrynafen for thiazide diuretics in the treatment of hypertension. (<i>JAMA</i>243:763-764, 1980)
Adductor canal outlet syndrome
Authors: M. R. Balaji
Journal: JAMA (1981)

On rare occasions, jogging, skiing, and other athletic activities can cause thrombosis of the superficial femoral artery at the outlet of Hunter's canal. We report three cases in which mechanical trauma of the femoral artery in Hunter's canal resulted in intimal tear and a segmentally localized thrombosis. It was confirmed by anatomic dissection that the intrinsic mechanical trauma occurred at the point where the femoral artery crosses the adductor magnus tendon. This tendon has been previously implicated as a cause of atherosclerotic stenosis and thrombosis. An awareness of its possible relationship to acute intimal injury and thrombosis may result in saving limbs that would otherwise be lost. (<i>JAMA</i>1981;245:167-170)
Efficacy and toxicity of pegaspargase and calaspargase pegol in childhood acute lymphoblastic leukemia/lymphoma: Results of DFCI 11-001.
Authors: Lynda M. Vrooman, Traci M. Blonquist, Jeffrey G. Supko, Sarah K. Hunt, Jane E. O'Brien, Samantha Kay-Green, Uma H. Athale, Luis Antonio Clavell, Peter D. Cole, Marian H. Harris, Kara M. Kelly, Caroline Laverdiere, Jean-Marie Leclerc, Bruno Michon, Jennifer JG Welch, Kristen E. Stevenson, Donna S. Neuberg, Stephen E. Sallan, Lewis B. Silverman
Journal: Journal of Clinical Oncology (2019)

10006 Background: DFCI ALL Consortium Protocol 11-001 assessed the efficacy and toxicity of Calaspargase pegol (SC-PEG), a novel pegylated asparaginase (ASP) formulation with longer half-life, compared with standard pegaspargase (SS-PEG). Methods: Patients (pts) aged 1-21 years with newly diagnosed acute lymphoblastic leukemia (ALL) or lymphoblastic lymphoma (LL) were eligible. At study entry, pts were randomly assigned to receive either intravenous SS-PEG or SC-PEG, 2500 IU/m2/dose. Pts received 1 dose during the first treatment month. Beginning week 7, SS-PEG was administered every 2 weeks for 15 doses, SC-PEG every 3 weeks for 10 doses (30 weeks). Serum asparaginase activity (SAA) (considered therapeutic at ≥ 0.1 IU/mL) was assessed 4, 11, 18, and 25 days after the induction dose and before each post-induction dose. End-induction minimal residual disease (MRD) was assessed in ALL pts by IGH/TCR PCR. Results: Between 2012-2015, 239 eligible pts enrolled (230 ALL, 9 LL); 120 assigned to SS-PEG, 119 to SC-PEG. After dose 1, SAA remained ≥ 0.1 IU/mL in ≥ 95% of pts on both arms through day 18. Median SAA was higher (0.319 IU/mL vs 0.056 IU/mL) and more pts had therapeutic SAA (88% vs 17%, p˂0.001) with SC-PEG vs SS-PEG 25 days after dose 1. Post-induction, median nadir SAA (NSAA) were similar ( &gt; 1.0 IU/mL) for both arms. There was no difference in rates of ASP-allergy, pancreatitis, thrombosis, hyperbilirubinemia, osteonecrosis, or infection. Of 230 evaluable pts, 99% of SS-PEG and 95% of SC-PEG pts achieved complete remission (p = 0.12). For B ALL pts, there was no difference in frequency of high end-induction MRD (10.3% SS-PEG, 9.5% SC-PEG, p = 1.0). With 4-year median follow-up, 4-year event-free survival (EFS) (90% confidence interval) for SS-PEG was 90.2% (84.3, 93.9), 87.7% (81.5, 91.9) for SC-PEG (p = 0.78); overall survival (OS) was 95.6% (91.0, 97.9) for SS-PEG, 94.8% (90.0, 97.3) for SC-PEG (p = 0.74). Conclusions: Every 3-week SC-PEG had similar EFS, OS, safety profile, and NSAA compared with every 2-week SS-PEG. The high NSAA observed for both preparations suggest dosing strategies can be further optimized. These data informed FDA approval of SC-PEG for pediatric pts. Clinical trial information: NCT01574274.
Radiation therapy in cancer of the larynx
Authors: M. Lederman
Journal: JAMA (1972)

Unlike bronchial cancer, which has assumed almost epidemic proportions in many countries, cancer of the trachea is rare, and cancer of the larynx is uncommon. Laryngeal cancer, nevertheless, resembles bronchial cancer in being essentially a disease of men who smoke. Because of its accessibility to investigation, laryngeal cancer has been studied in detail; three regional and very different varieties of cancer have been recognized as occurring within this limited and specialized part of the upper respiratory tract.<sup>9</sup>The glottis, formed by the vocal cords, is the seat of 70% of these cancers; in 20% of cases, the supraglottis, ie, the region between the margins of the laryngeal opening and the epiglottis, is affected; the rarest laryngeal cancer site is the subglottic region, between the vocal cords and the lower border of the cricoid cartilage, where the incidence is 10%. The favorable features of laryngeal cancer are its relatively slow
Successful Peripheral T-Lymphocyte–Directed Gene Transfer for a Patient With Severe Combined Immune Deficiency Caused by Adenosine Deaminase Deficiency
Authors: Masafumi Onodera, Tadashi Ariga, Nobuaki Kawamura, Ichiro Kobayashi, Makoto Ohtsu, Masafumi Yamada, Atsushi Tame, Hirofumi Furuta, Motohiko Okano, Shuzo Matsumoto, Hitoshi Kotani, Gerard J. McGarrity, R. Michael Blaese, Yukio Sakiyama
Journal: Blood (1998)
THE NEED FOR EXTENDED SICKNESS INSURANCE
Authors: D. of Penn
Journal: BMJ (1924)

puiblic health commitfee.It is pointed out also that in organizing arrangements to meet the requiremefits of each area, much wider use could, with great advantage to the services, be made of the expert staff-medical and nursing --of the mental hospitals servi'ng that area.If these suggestions were carried ou't a much more attractive career would be possible for the mental nurse than is at present offered, and there would be every inducement for educated persons to take up this work as a vocation.
O036 : Overexpression of c-myc in hepatocytes promotes initiation and progression of alcoholic liver disease
Authors: Y.A. Nevzorova, W. Hu, F.J. Cubero, U. Haas, N. Gassler, P. Strnad, H.W. Zimmermann, C. Trautwein, C. Liedtke
Journal: Journal of Hepatology (2015)
Acupuncture treatments for pain relief
Authors: G. A. Ulett
Journal: JAMA (1981)

ACUPUNCTURE is the most controversial of nondrug pain control methods in contemporary US medicine. This form of treatment originated in China some 4,000 years ago. It has been of interest in the United States for scarcely a decade although widely used in Europe since early in this century and universally acclaimed for its pain-relieving qualities. <h3>Traditional Acupuncture</h3> United States physicians have failed to embrace acupuncture for several reasons, but mainly because, as it is usually presented to them, it has lacked documented scientific validity and has been taught as a practice based on ancient Taoist philosophy passed down through the centuries with relatively little change. The many texts and frequent seminars on acupuncture all adhere to this traditional approach with its fanciful theories. In this archaic acupuncture theory, man is thought to be a microreflection of the cosmos with two major forces (yin and yang) affecting his energy balance (<i>chi</i>
Successive Picas
Authors: MOSS JOEL
Journal: Annals of Internal Medicine (1974)

ExcerptTo the editors We have read with interest the comments by Drs. Chandra and Rosner (Ann Intern Med 79:973-974, 1973) and Marks (Ann Intern Med 79: 612, 1973) on olive or lettuce craving in iron-deficiency anemia. We have had in our care an elderly lady with two different cravings in marked iron deficiency. The remarkable aspect of this patient's cravings was that before the start of therapy, one pica gave way to another.A 78-year-old diabetic housekeeper had a hematocrit of 40 in 1960. In November 1972 she was hospitalized at Good Samaritan Hospital and then had a hematocrit of...
From the NIH
Journal: JAMA (1976)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Satellite Videoconference on Epidemiology and Prevention of Vaccine-Preventable Diseases
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Annual Meetings of American Society of Cytology
Journal: JNCI Journal of the National Cancer Institute (1972)

Annual Meetings of American Society of Cytology Get access JNCI: Journal of the National Cancer Institute, Volume 48, Issue 5, May 1972, Page 1554, https://doi.org/10.1093/jnci/48.5.1554-a Published: 01 May 1972
INDUSTRIAL HOSPITALS
Authors: R. A. Bolam, R. Orde
Journal: BMJ (1920)

THE cEaracter of tlle British hospital of the future will be largely determined by tlle first steps talken to make use of tlle hospital beds at present vacant in Poor Law insti- tutions.That use must be ni'ade of tllese beds, or a portion of them, almost at once is generally agreed.Patients cannot much longer be allowed to lie untreated in tlleir homues, often withlin a stone's throw of admirable hospital accommodation.
Are Surgical Marking Pens Safe?
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cryptosporidiosis
Authors: Angel N. Desai
Journal: JAMA (2020)

CryptosporidiosisCryptosporidiosis is an infection caused by the parasite Cryptosporidium that can lead to diarrhea.Cryptosporidium parasites are spread through direct contact with infected people or animals or exposure to fecal contamination of water, soil, food, or the hands of exposed individuals.Once ingested, the parasite causes infection in the small intestine.Rarely, Cryptosporidium can cause disease outside of the gastrointestinal tract as well.The disease's effects range from no symptoms to death in certain cases and depend onmanyfactors,includingtheunderlyinghealthoftheinfectedpatient.Cryptosporidiosis occurs around the world but is more common in regions with inadequate sanitation and hygiene.Cryptosporidium parasites are resistant to many common disinfectants including chlorine, which can make infection difficult to eradicate.Outbreaks of cryptosporidiosis from contaminated drinking water occurred in Texas in 1984 and Milwaukee in 1993.More recently, large-scale outbreaks have been linked to recreational water activities and child care centers.
Erratum
Journal: BMJ (1893)

regards the seizure and condemnation of unsound food, so as to avoid difficulties which had arisen in practice.The learned London magis- trates ought, therefore, to have less trouble than their unlearned brethren in the country.But under the genleral Act of 1875 there is no necessity for bringing unsound food before a court of summary juris- diction or before a magistrate in court.The Act requires that the food, when seized, shall be brought before " a justice," but does not say "in his court; " and its requiremeents are satisfied if the justice goes to view or smell the article seized.This is common sense, for the more obviously bad the food may be the greater the nuisance and risk to the public of bringing it into the proxnimity of a crowded court.If criminal proceedings are taken against the owner of the food seized, they must, of course, be conducted in court according to ordinary rules; but the preliminary process of condemnation should be managed as promptly and as quietly as possible.
REGURGITATED ECTOPLASM
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract LB-248: BRAFV600E remodels the melanocyte transcriptome and induces BANCR to regulate melanoma cell migration.
Authors: Ross J. Flockhart, Dan E. Webster, Kun Qu, Nicholas Mascarenhas, Joanna Kovalski, Markus Kretz, Khavari A. Paul
Journal: Cancer Research (2013)

Abstract Aberrations of protein-coding genes are a focus of cancer genomics; however, the impact of oncogenes on expression of the ~50% of transcripts without protein-coding potential, including long noncoding RNAs (lncRNAs), has been largely uncharacterized. Activating mutations in the BRAF oncogene are present in &amp;gt;70% of melanomas, 90% of which produce active mutant BRAF(V600E) protein. To define the impacts of oncogenic BRAF on the melanocyte transcriptome, massively parallel cDNA sequencing (RNA-seq) was performed on genetically matched normal human melanocytes with and without BRAF(V600E) expression. To enhance potential disease relevance by verifying expression of altered genes in BRAF-driven cancer tissue, parallel RNA-seq was also undertaken of two BRAF(V600E)-mutant human melanomas. BRAF(V600E) regulated expression of 1027 protein-coding transcripts and 39 annotated lncRNAs, as well as 70 unannotated, potentially novel, intergenic transcripts. These transcripts display both tissue-specific and multi-tissue expression profiles and harbor distinctive regulatory chromatin marks and transcription factor binding sites indicative of active transcription. Coding potential analysis of the 70 unannotated transcripts suggested that most may represent newly identified lncRNAs. BRAF-regulated lncRNA 1 (BANCR) was identified as a recurrently overexpressed, previously unannotated 693-bp transcript on chromosome 9 with a potential functional role in melanoma cell migration. BANCR knockdown reduced melanoma cell migration, and this could be rescued by the chemokine CXCL11. Combining RNA-seq of oncogene-expressing normal cells with RNA-seq of their corresponding human cancers may represent a useful approach to discover new oncogene-regulated RNA transcripts of potential clinical relevance in cancer. Citation Format: Ross J. Flockhart, Dan E. Webster, Kun Qu, Nicholas Mascarenhas, Joanna Kovalski, Markus Kretz, Khavari A. Paul. BRAFV600E remodels the melanocyte transcriptome and induces BANCR to regulate melanoma cell migration. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr LB-248. doi:10.1158/1538-7445.AM2013-LB-248
Cockayne's Syndrome with Chromosomal Analysis
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal