tbuckley/cabot-search huggingface dataset:
Clinical Inertia
Authors: James L. Wofford
Journal: Annals of Internal Medicine (2002)

Letters17 September 2002Clinical InertiaJames L. Wofford, MD, MSJames L. Wofford, MD, MSWake Forest University School of Medicine; Winston-Salem, NC 27157Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-137-6-200209170-00025 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:To be fair to the concept of inertia, best defined here as an indisposition to change, it should be acknowledged that inertia works in both directions. The attractive concept of clinical inertia proposed by Phillips and colleagues (1) should also encompass the failure of health care providers to stop or deescalate therapy. Treatment regimens too often contain medications that are continued indefinitely for little or no reason. Commonly encountered examples of lingering medications are gastric protective agents initiated long ago in the hospital for stress ulcer prophylaxis and hormone replacement therapy that no longer has clear-cut indications.... Reference1. Phillips LS, Branch WT, Cook CB, Doyle JP, El-Kebbi IM, Gallina DL, et al . Clinical inertia. Ann Intern Med. 2001;135:825-34. [PMID: 11694107] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Wake Forest University School of Medicine; Winston-Salem, NC 27157 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoClinical Inertia Lawrence S. Phillips , William T. Branch Jr. , Curtiss B. Cook , Joyce P. Doyle , Imad M. El-Kebbi , Daniel L. Gallina , Christopher D. Miller , David C. Ziemer , and Catherine S. Barnes Clinical Inertia Daniel Reinharth Clinical Inertia Lawrence S. Phillips , Joyce P. Doyle , and William T. Branch Jr. Clinical Inertia Michael Steinberg Metrics Cited ByDrug utilisation study of antidiabetic medication during 2012‐2019 in RomaniaClinical Inertia in Dentistry: A Review of the Phenomenon 17 September 2002Volume 137, Issue 6Page: 547KeywordsGastric ulcersHealth care providersHormone replacement therapyPerceptionProphylaxis ePublished: 17 September 2002 Issue Published: 17 September 2002 CopyrightCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
New Clinical Observations on Virus Hepatitis
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
“Vitamin D and skeletal muscle strength and endurance in COPD.” Abigail S. Jackson, Dinesh Shrikrishna, Julia L. Kelly, Samuel V. Kemp, Nicholas Hart, John Moxham, Michael I. Polkey, Paul Kemp and Nicholas S. Hopkinson.<i>Eur Respir J</i>2013; 41: 309–316.
Journal: European Respiratory Journal (2013)
Prevalence and characterization of neutrophil cytoplasmic antibodies in autoimmune liver diseases
Authors: A Mulder
Journal: Hepatology (1993)

To evaluate the diagnostic significance of neutrophil cytoplasmic antibodies in chronic liver diseases, we assessed the prevalence of neutrophil cytoplasmic antibodies in autoimmune liver diseases, in particular in primary sclerosing cholangitis, autoimmune chronic active hepatitis and primary biliary cirrhosis, and we also determined the specificity of perinuclear-pattern neutrophil cytoplasmic antibodies for these autoimmune liver diseases by testing sera from patients with nonautoimmune chronic liver diseases. Neutrophil cytoplasmic antibodies were detected in 79% of sera from patients with primary sclerosing cholangitis (n = 24), in 88% of sera from patients with autoimmune chronic active hepatitis (n = 24) and in 28% of sera from patients with primary biliary cirrhosis (n = 25). The presence of neutrophil cytoplasmic antibodies in these diseases correlated significantly (p<0.008) with the presence of cirrhosis. Neutrophil cytoplasmic antibodies were not detected in nonautoimmune liver diseases. All neutrophil cytoplasmic antibody–positive sera produced a perinuclear fluorescence pattern on ethanol-fixed granulocytes. On neutrophils fixed with paraformaldehyde, a granular cytoplasmic immunofluorescence pattern was observed, demonstrating the cytoplasmic nature of the antigen or antigens involved. Further characterization studies showed that neutrophil cytoplasmic antibodies in autoimmune liver diseases are not directed against myeloperoxidase, proteinase 3 or elastase, the neutrophil cytoplasmic antibody specificities associated with necrotizing vasculitis, glomerulonephritis or both. On Western blots neutrophil cytoplasmic antibodies in autoimmune liver diseases showed reactivity with either lactoferrin, a 67/66-kD protein combination or a 40-kD polypeptide. Reactivity with either of these proteins was observed in sera from patients with primary sclerosing cholangitis (38%), autoimmune chronic active hepatitis (17%) and primary biliary cirrhosis (20%). Because the same specificities have been found in neutrophil cytoplasmic antibody–positive sera from patients with inflammatory bowel disease and rheumatoid arthritis, these data suggest that these neutrophil cytoplasmic antibodies are a corollary of chronic inflammation. (HEPATOLOGY 1993;17:411–417.)
Influence of prostate cancer disease state and therapeutic selection on peripheral whole-blood RNA signature.
Authors: Bobby Chi-Hung Liaw, Uma Chippada-Venkata, Yixuan Gong, Li Wang, Jun Zhu, Matthias Michael Heck, Che-Kai Tsao, Matt D. Galsky, William K. Oh
Journal: Journal of Clinical Oncology (2015)

5046 Background: Prostate cancer is a heterogeneous disease with differences in tumor stromal interactions contributing to variability in treatment response and outcome. Gene expression of peripheral blood cells is altered by interactions with neoplastic tissue. We previously developed a peripheral whole blood six-gene signature prognostic for survival in mCRPC. Here we evaluate how different clinical disease states and treatment with different therapeutic agents impact this signature. Methods: Whole blood was collected in PAXgene Blood RNA tubes in two cohorts of prostate cancer patients, one at Mount Sinai (n = 135), the other in Munich (n = 59), in the context of prospective clinical studies. Whole blood RNA was extracted and the six target genes were amplified using qPCR. Scores were derived using normalized cycle threshold (ΔCT) values of the six genes, according to the model: 2 x ABL2 + SEMA4D + ITGAL – C1QA – TIMP1 – CDKN1A. Patients were categorized by disease state in the Mount Sinai cohort, and by treatment received in the Munich cohort, for data analysis. Results: CRPC is the only disease state with a mean six-gene score (18.06) above the high-risk cutoff (17.9), and is significantly higher than localized or hormone sensitive advanced disease (16.07, 16.52, respectively; p = 0.0002). Among patients with localized disease, there was no significant difference in the mean six-gene scores for patients with low-, intermediate-, and high-risk disease (16.07, 15.33, 16.66, respectively; p = 0.27). In CRPC patients treated with docetaxel, there are significant changes to the six-gene score over the course of treatment (p = 0.002), with a notable percentage decrease (-6.2%) at the 2-8 week timepoint that is not observed in patients treated with abiraterone or enzalutamide. Conclusions: Gene expression profiling of whole blood is influenced by the clinical state of prostate cancer as seen by differences to the six-gene score from localized to castrate resistant disease. Cytotoxic chemotherapy appears to modulate the six-gene score, something not seen with AR-directed therapies. Further investigation will be needed to understand the significance of these changes.
CORTICOSTEROIDS IN DEPRESSIONS
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Atrial Myxoma
Authors: M Usman Ali, Jonathan Finkel
Journal: New England Journal of Medicine (2018)

A 47-year-old woman presented with exertional dyspnea and orthopnea. Echocardiography revealed a mass attached to the interatrial septum, with partial prolapse into the left ventricle obstructing mitral-valve inflow (shown in a video). Atrial myxoma was diagnosed.
Errors in Editorial.
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Serologic Detection of Gonorrhea
Authors: JOHN D. SCHMALE
Journal: Annals of Internal Medicine (1970)

Editorials1 April 1970Serologic Detection of GonorrheaJOHN D. SCHMALE, M.D.JOHN D. SCHMALE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-72-4-593_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSerology has long been used to identify inapparent infections or infections due to organisms not easily or conveniently cultured. Thus, virologic diagnosis uses complement-fixation or hemagglutination-inhibition reactions, and syphillis serology relies on flocculation and indirect fluorescent antibody testing.The use of serology in detection of gonorrhea has a different basis because in most gonococcal infections the organism can readily be cultured on Thayer-Martin medium (the possible exception being in gonococcal arthritis). Serology in gonorrhea is not so much needed as a diagnostic test but for epidemiological screening. At present, the epidemiological study of gonorrhea is difficult because of the short...References1. SCHMALEMARTINDOMESCIK JJG: Observations on the culture diagnosis of gonorrhea in woman. JAMA 210:312-314, 1969 CrossrefMedlineGoogle Scholar2. MULLEROPPENHEIM RM: Ueber den Nachweis von Antikorpern im Serum eines an Arthritis gonorrhoica Erkrankten mittels Komplementablenkung. Wien klin Wschr 19:894-898, 1906 Google Scholar3. MAGNUSSONKJELLANDER BJ: Gonococcal complement-fixation test in complicated and uncomplicated gonorrhea. Brit J Vener Dis 41:127-131, 1965 MedlineGoogle Scholar4. REISINGSCHMALEDANIELSSON GJD: Reactivity of two selected antigens of Neisseria gonorrhoeae. Appl Microbiol 18:337-339, 1969 CrossrefMedlineGoogle Scholar5. LEESCHMALE LJ: Identification of a gonococcal antigen important in the human immune response. Infection and Immunity 1:207-208, 1970 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe epidemiology and control of gonorrhea and syphilis: A reappraisalDisseminated Gonococcal InfectionKING K. HOLMES, M.D., Ph.D., GEORGE W. COUNTS, M.D., HARRY N. BEATY, M.D., F.A.C.P.Navajo Arthritis—an Unusual, Acute, Self-Limited Disease 1 April 1970Volume 72, Issue 4Page: 593-595KeywordsArthritisGonorrheaSerology Issue Published: 1 April 1970 PDF downloadLoading ...
Cocarcinogenicity of Phenols from Estonian Shale Tars (Oils)
Authors: P. A. Bogovski, H. I. Mirme
Journal: Environmental Health Perspectives (1979)

Many phenols have carcinogenic activity. The Estonian shale oils contain up to 40 vol % phenols. The promoting activity after initiation of phenols of Estonian shale oils was tested in mice with a single subthreshold dose (0.36 mg) of benzo(a)pyrene. C57Bl and CC57Br mice were used in skin painting experiments. Weak carcinogenic activity was found in the total crude water-soluble phenols recovered from the wastewater of a shale processing plant. In two-stage experiments a clear promoting action of the total crude phenols was established, whereas the fractions A and B (training reagents), obtained by selective crystallization of the total phenols exerted a considerably weaker promoting action. Epo-glue, a commercial epoxy product produced from unfractionated crude phenols, had no promoting activity, which may be due to the processing of the phenols involving polymerization. The mechanism of action of phenols is not clear. According to some data from the literature, phenol and 5-methylresorcinol reduce the resorption speed of BP in mouse skin, causing prolongation of the action fo the carcinogen.
AIDS Therapy
Authors: Renslow Sherer
Journal: Annals of Internal Medicine (1999)

Medical Writings: Book Notes16 November 1999AIDS TherapyRenslow Sherer, MDRenslow Sherer, MDThe CORE Center, Cook County Hospital, Rush Medical College, Chicago, Illinois. (Sherer)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-131-10-199911160-00039 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Dolin R, Masur H, Saag H, eds. 863 pages. Philadelphia: Churchill Livingstone; 1999. $150.00. ISBN 0443075921. Order phone 800-543-1918.Field of medicine: HIV and AIDS medicine.Format: Hardcover book.Audience: HIV and AIDS physicians, clinicians, and clinical pharmacists, among other health care providers.Purpose: To provide a comprehensive, up-to-date, and practical source of information on HIV and AIDS therapy.Content: Major topics covered include individual antiretroviral agents; immune-based and alternative therapies; highly active antiretroviral therapy, including its use in pregnant patients, as postexposure prophylaxis, and for acute HIV infection; individual opportunistic infections and their management; approaches to specific organ syndromes, ... Author, Article, and Disclosure InformationAffiliations: The CORE Center, Cook County Hospital, Rush Medical College, Chicago, Illinois. (Sherer) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 16 November 1999Volume 131, Issue 10Page: 800KeywordsAIDSAntiretroviralsForecastingHIVHighly active antiretroviral therapyInternetOpportunistic infectionsPregnancySoftware toolsTreatment guidelines ePublished: 15 August 2000 Issue Published: 16 November 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
New Emphasis on Stroke Prevention
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Correction.
Authors: W. W. Keen
Journal: JAMA (1890)

<h3>To the Editor:</h3> —Mr. J. Greig Smith has called my attention to my unintentional misstatement of his views on page 643 ofThe Journal, for November 1, 1890. I hasten to say, therefore, that a reference to his " Abdominal Surgery " shows that he has clearly stated that floating kidney is always congenital, but movable kidney as a rule is acquired. Very truly yours, 1729 Chestnut St., Philadelphia, Dec. 1, 1890.
A 57-Year-Old Man With Osteoarthritis of the Knee
Authors: Nadine Farag, Amy Ship, Jess H. Lonner
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Official Call to the Officers and Members of the American Medical Association to Attend the Interim Meeting of the House of Delegates in Los Angeles, Dec 4 to 7, 1983
Journal: JAMA (1983)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Circulation Research Thematic Synopsis
Journal: Circulation Research (2013)

The goal of Thematic Synopses is to provide our readers with a concise but comprehensive overview of the work published in Circulation Research, which we hope will keep our readers abreast of recent scientific discoveries and facilitate discussion, interpretation, and integration of the findings.These collections of articles are organized thematically and the papers listed in chronological order, beginning with the most recent ones.In each synopsis, the top downloaded original research articles (normalized to time since publication) are highlighted in yellow.Review articles are also included with titles highlighted in blue and the summary of each is provided.Instead of using abstracts, we have elected to publish the Novelty and Significance section of each article, which we believe provides a clear précis of the salient findings and their implications in a language that is easily understandable by the non-initiated.This will enable readers who are not experts in a particular field to grasp the significance and impact of work performed in other fields.It is our hope and expectation that Thematic Synopses will help readers to gain a broader awareness and a deeper understanding of the status of research across the vast landscape of cardiovascular research.-