tbuckley/cabot-search huggingface dataset:
The Structure and Growth of the Tissues: A Short Account of the Conclusions derived from some New Observations with the Highest Magnifying Powers
Authors: L. S. Beale
Journal: BMJ (1861)

temperature, which, however slight, are highly in- WSrouiS Thirdly, it mixes a warm steam with the r spired air, by diffusing it for at least a foot or two iol the patient.A damp warm atmosphere is of grst importance in pneumonia; and you may have Observed that I have endeavoured to secure it by bjaing basins of warm water placed about the wards, Aiaddition to the poultices.john D., aged :9, a dustnman, was admitted Jan. I0th.xe stated that he had been subject to what lie called a little chiselling cough for five years, but never so as to be prevented from working.He was in the habit of taking as reah gin as he could get.A week before admission, he went to his labour as usual at 6 A.M.; but at about 9 o'clock he was seized with such a severe shivering fit that be was unable to stand, and was carried home to bed.The dyspncea was very great, but still he had no medical ,duice till lie came here.The pulse was very weak, iAplar, about 100.The face was very livid, and the 4yspnea very urgent.There was high toned sibilant brestbing over all the chest, mixed behind with fine r~es or fine crepitation; and dulness on percussion be.seath both scapula.He was ordered- O Antimonii pot.-tart.gr. 1-6; potassm nitratis gr.x; etheris chlorici nix; aqum 3j. 31.Fiat haustus quartis horis sumendus.The chest was enveloped in poultices.The next day the breath was easier; but still, considering the Wakness and irregularity of pulse and his alco- lolised constitution, he was ordered three ounces of gi daily.On the following day (the 18th), the pulse was stronger and less frequent, being 716.He perspired much, but was not nauseated by the anti- mmoy.To-day (the 19th), he is going on well, and will probably struggle through.In all sorts of pneumonia, but especially in this -ironcho-pneumonia, the rigors are very strong, and mark distinctly the commencement of the disease.You can date its beginning more easily than other binammations.I recited this last history to call lour attention to the fact.Whenever you hear that a manhas had such a severe rigor that he is knocked Jown suddenly when at work, like John D., or is woke up by it in bed, like Joseph C., you should ialys suspect pneumonia is coming.About the other cases of broncho-pneumonia, I have no fresh remarks to make.One has a dilated heart; one albuminuria; and two, who came in mo- ibund, seem to have been starved.Ailments of this severity in remote parts complicate the symptoms more than anatomical changes in the lung itself.To recapitulate:1. Certain atmospheric conditions cause inflamma- tion of the lungs.
SAT-294-Automated quantitation of steatosis, inflammation, ballooning and fibrosis using machine learning in routine histological images of liver biopsies of patients with NAFLD
Authors: Roberta Forlano, Benjamin H. Mullish, Nikos Giannakeas, James Maurice, Markos Tsipouras, Alexandros Tzallas, Michael Yee, Josephine Lloyd, Robert D. Goldin, Mark Thursz, Pinelopi Manousou
Journal: Journal of Hepatology (2019)
INDUCED ATROPHY OF HYPERTROPHIED TONSILS BY ROENTGEN RAY
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Analysis of Mutagens from Cooked Foods by Directly Combined Liquid Chromatography-Mass Spectrometry
Authors: Charles G. Edmonds, Satinder K. Sethi, Ziro Yamaizumi, Hiroshi Kasai, Susumu Nishimura, James A. McCloskey
Journal: Environmental Health Perspectives (1986)

Directly combined high performance liquid chromatography-mass spectrometry (LC/MS) has been studied as a method of analysis of heterocyclic aromatic mutagens in cooked foods, in the parts per billion concentration range. Identification and semiquantitative estimation of mutagens is based on accurate measurement of chromatographic retention (k') and molecular weight-selective detection of mutagens, which are protonated during passage of the chromatographic eluant into a thermospray interface of a quadrupole mass spectrometer. Standard chromatographic retention (k') values in two reversed-phase systems and data from thermospray mass spectra from nine mutagens are reported. An isolation scheme employing CH3OH extraction, acid-base partition, cellulose-trisulfo-Cu-phthalocyanine adsorption, and normal-phase HPLC was used prior to LC/MS analysis. Initial applications have been demonstrated in the analysis of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ) in broiled salmon flesh. Levels measured were estimated to be in the range 0.2 to 0.4 microgram/kg IQ and 0.4 to 0.9 microgram/kg MeIQ. The method is judged to be generally applicable with minimal sample prefractionation to detection of mutagens at the parts per billion level in cooked foods.
FRI0218 Shared epitope positivity is related to efficacy of abatacept in rheumatoid arthritis
Authors: K Oryoji, K Yoshida, S-I Mizuki
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Abatacept, a soluble fusion protein composed of the extracellular domain of CTLA-4 molecule and the Fc portion of human IgG1, is approved therapy for RA by the mechanism of binding to CD80/86 (B7–1/B7–2) on antigen presenting cell (APC), and blocking the B7:CD28 interaction. Meanwhile, it is suggested that HLA-DRB1 shared epitope (SE) associates with the production of ACPA through MHC molecule-based antigen presentation. Moreover, the association between the efficacy of abatacept and the positivity for anti-cyclic citrullinated peptide antibody (ACPA) was reported. Thus, we speculated that there may be correlation between the efficacy of abatacept and patients9 HLA-DRB1 SE positivity, so we investigated correlation between the clinical efficacy of abatacept in RA patients and their HLA-DRB1 genotype. <h3>Objectives</h3> To identify the relation between the efficacy of abatacept on patients with rheumatoid arthritis (RA) and their HLA-DRB1 phenotype including whether having shared epitope (SE). <h3>Methods</h3> HLA-DRB1 phenotype of 72 patients treated with abatacept was identified, and divided into 2 group, SE (HLA-DRB1 0101, 0401, 0404, 0405, 0408, 1001) positive and SE negative. To overcome potential bias, multivariate logistic regression analysis was done in this retrospective cohort. <h3>Results</h3> They were divided into 47 SE positive patients (65.3%) and 25 SE negative patients (34.7%). The retention rate of abatacept treatment at week 52 were 95.3%/47.1% (SE positive/SE negative, p&lt;0.0001, log-rank test), respectively. Adjusted hazard ratio for abatacept discontinuation due to lack of efficacy was 8.94 (95% CI: 2.95–34.1, p&lt;0.0001, Multivariable Cox proportional hazards regression model) in SE negative group compared to SE positive group. The EULAR good response rate at week 24 were 74.5%/20.0% (SE positive/SE negative, p&lt;0.0001, Fisher9s exact test), respectively. Simplified Disease Activity Index (SDAI) remission rate at week 24 were 55.3%/20.0% (SE positive/SE negative, p=0.004, Fisher9s exact test), respectively. Multivariate logistic regression revealed the odds ratio of EULAR good response and SDAI remission achievement in SE positive patients was 23.2 and 6.73 (95% CI: 5.10–152.0, p&lt;0.0001 and 1.70–32.3, p=0.006), respectively. <h3>Conclusions</h3> Abatacept is strictly effective to SE positive RA patients. <h3>Disclosure of Interest</h3> K. Oryoji Grant/research support from: Ono, Speakers bureau: Abbvie, Chugai, Astellas, Mitsubishi-Tanabe, Pfizer, Janssen, Eisai, UCB and Ono, K. Yoshida: None declared, S.-I. Mizuki Speakers bureau: Abbvie, Astellas, Mitsubishi-Tanabe, Pfizer, Janssen, Eisai, UCB and Ono
Errata
Journal: BMJ (1898)

weakness or annemia, or become pregnant again.He states that lacta- tion is often prolonged to two, three, or four years among many savage races, African and Asian; and adds that in Japan, where the usual period of lactation is three or four years, the mortality among children under 5 years of age is low, since of i,ooo born 276 die before the age of 5 years in Japan, whereas 341 die in France.SWISS AND GEBRMAN CLIMATE AND SCHOOLS. A. Z. desires to hear of any healthy spot in Switzerland or Germany where the climate in winter is mild or in summer not too relaxing, and where a European girl, 8 years of age, born and bred In Burmah, could live en pension with her mother and obtain educational advantages.*** Lausanne, on the Lake of Geneva, is a well-known centre for edu- cation; theextremes of heat and cold are greater there than in England, but this is the case everywhere in Switzerland and Germany.Clarens and Montreux, also on the Lake of Geneva, are more sheltered and warmer in winter; the schools for children are also very good.In all these places French is the language spoken and there are numerous first-rate pensions.In Germany, Heidelberg or Wiesbaden would pro- bably be found most suitable.In the German part of Switzerland the schools are excellent, but the climate' is everywhere more severe than on the Lake of Geneva.HoME0 FOR IMBECILE.F.W.K. (London, E.) desires to know of an institution for an imbecile boy of I6 years, harmless, but with very slight promise of any improvement in mental power.Hiis parents cannot afford to pay more than Ios. or 128.per week.*** The case might be admitted at the Imbecile Asylum, Darenth.r Application should be made to the relieving officer of the district. ANSWERS.ENQUIRER.-There are a variety of such " cures."As they are proprietary secret remedies or processes we are unable to afford any information.PROVIDENT.-NOinformation has been received,for rsome time as to the position of the association mentioned.RuSTIC will find a number of receipts for the various pastes, etc., used in the saddle room in Workshop Receipts for the Use of Manufacturers, Mechanics, and Scientific Amateur8, by Ernest Spon, published by E. and F. Spon, 125, Strand, W.C.; price 58.
Use of a colonoscope to perform endoscopic therapy in patients with active bleeding from posterior duodenal and gastric ulcers
Authors: K. Mönkemöller, H. Neumann, M. Bellutti, P. Malfertheiner, L. Fry
Journal: Endoscopy (2009)

Correction to: Use of a colonoscope to perform endoscopic therapy in patients with active bleeding from posterior duodenal and gastric ulcersEndoscopy 2009; 41(S 02): E93-E94DOI: 10.1055/s-0029-1214485
Risk factors for development of microalbuminuria in insulin dependent diabetic patients: a cohort study. Microalbuminuria Collaborative Study Group, United Kingdom.
Authors: Drjeannie Yip
Journal: BMJ (1993)

To investigate the risk factors for the development of persistent microalbuminuria in insulin dependent diabetic patients.Four year follow up of a cohort of diabetic patients.Outpatient departments of teaching and district general hospitals in England.148 non-microalbuminuric, non-hypertensive insulin dependent diabetic patients.Urinary albumin excretion rate and arterial blood pressure.137 patients completed four year follow up, of whom 11 developed persistent microalbumin-uria (albumin excretion rate > or = 30 micrograms/min on at least two consecutive occasions), giving a cumulative frequency of 8%. 103 remained normoalbuminuric and 23 exhibited intermittent microalbuminuria. At baseline the persistent microalbuminuric group had had significantly raised blood pressure (mean 137.9 (SD 14.9)/82.3 (7.6) v 123.5 (13.2)/72.8 (9.1) mm Hg), glycated haemoglobin concentration 10.4% (2.0%) v 8-9% (2.0%), and albumin excretion rate (median (interquartile range) 17.5 (13.0-22.3) v 4.8 (3.7-6.7) micrograms/min) (p < 0.05 for all) compared with the normo-albuminuric group. Blood pressure and glycated haemoglobin remained significantly higher in the persistent microalbuminuric group throughout the study (p < 0.05). Multiple regression analysis showed initial albumin excretion rate, blood pressure, and smoking to be significant determinants of persistent microalbuminuria (p < 0.02).In insulin dependent diabetic patients with poor glucose control, which may initially increase albumin excretion rate, an early rise of arterial pressure and smoking are implicated in the development of persistent microalbuminuria.
Hospital Care
Authors: Bernard J. Yukna
Journal: JAMA (1978)

<h3>To the Editor.—</h3> I read the article by Harold Vanderpool, MD (239:850, 1978), with great interest. Those of us involved in the care of the terminally ill have wrestled with the concept of "death with dignity." Somehow it never seemed to say what it should have. Dr Vanderpool has done an admirable job of setting forth certain fundamental features of human worth. These fundamentals underlie the growing hospice movement throughout the United States at the present time. Hospice care is a modality of treatment that is holistic. The terminally ill patient is continually reassessed with respect to the human worths mentioned: respect for the individual, inclusion in a community, concern for the body, and consideration of a broader purpose in life. A team approach is used because no one individual can relate to the patient in all his spheres of being. A typical care-giving team might include the family, physician,
Book Review Provoked Alimentary Hyperglycemia: The mechanism of the tolerance test . Joseph M. Flint. 37 pp. The Effect of the Macallum-Laughton Duodenal Extract Upon Hypophyseal Diabetes. Joseph M. Flint and Louis Michaud. 77 pp. London, Ontario: A. B. Macallum, 1939.
Journal: New England Journal of Medicine (1939)
Abstract 728: Development and validation of ColoScape™ - a new colorectal cancer mutation detection assay
Authors: Michael J. Powell, Elena Peletskaya, Anne Vallerga, Qing Sun, Larry Pastor, Aiguo Zhang
Journal: Cancer Research (2017)

Abstract Introduction: Colorectal cancer is a highly preventable disease as early detection increases rates of patient survival to near 100%. Herein we report the development and validation of a novel multigene mutation biomarker real-time PCR based assay for qualitative detection of colorectal cancer associated biomarkers that comprise tumor specific mutations in the following genes: APC (Exon 15), KRAS (Exon 2), BRAF (Exon 15) and CTNNB1 (Exon 3) called ColoScapeTM . The assay allows the sensitive detection of the presence or absence of mutations in the targeted regions of the genes interrogated. Methodology: The high sensitivity of this multigene biomarker assay is achieved due to xenonucleic acid (XNA) probe technology. XNA probes are novel backbone modified oligomers having natural nucleoside bases (A,T,C and G) that hybridize by Watson-Crick base pairing to natural DNA and RNA with much higher binding affinity than natural deoxyribonucleic acid oligomers of the same sequence. XNA probes are designed that bind to the selected wild-type sequences at the respective genetic loci in the target genes. These XNA probes have a much higher Tm than the primer annealing temperature and suppress amplification of WT DNA templates and only allow amplification of the target mutant DNA templates in the sample. Both single nucleotide polymorphisms (SNP’s) and insertion/deletions (indels) mutations can be detected. For each of the selected mutation sites primers and FAM-labeled TaqMan hydrolysis probes were designed and tested together with the selected XNA oligomers and analytical assay performance confirmed. An internal PCR control amplicon selected in the Human β-Actin (ACTB) gene was employed utilizing a HEX-labeled TaqMan probe. Performance parameters of the assay were established on DNA of colorectal cancer patients extracted from FFPE as well as reference DNA materials (synthetic and cell line derived DNA). The assay demonstrates high sensitivity and specificity in detection of colon cancer and adenoma samples based on the set of biomarkers involved in colorectal cancer neogenesis and disease progression. Conclusion: The ColoScapeTM Colorectal Cancer Mutation Detection assay is shown to be a sensitive tool intended to facilitate research in colon cancer development, early detection, disease monitoring and therapeutic interventions. Citation Format: Michael J. Powell, Elena Peletskaya, Anne Vallerga, Qing Sun, Larry Pastor, Aiguo Zhang. Development and validation of ColoScape™ - a new colorectal cancer mutation detection assay [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 728. doi:10.1158/1538-7445.AM2017-728
Rural medical care. Physician's assistant linked to an urban medical center
Authors: R. Oseasohn
Journal: JAMA (1971)

A system was designed to provide medical care to families in a rural community by means of a physician's assistant linked to an urban medical center. Medical services were defined in collaboration with the community. The assistant, a registered nurse and local resident, was trained to make observations, communicate, and act under physician supervision. The system has been operating for two years and has given care to over 500 families.
PLoS Medicine Issue Image | Vol. 8(2) February 2011
Journal: PLoS Medicine (2011)

Systematic reviews (overviews of health care interventions that use predefined methods to find and appraise all the relevant evidence) are generally thought to provide reliable evidence for decision-making in clinical practice, if carefully carried out and transparently reported. However, there is potential for bias in the conduct and reporting of systematic reviews through nonpublication of "negative" outcomes. Given this potential for bias, PLoS Medicine announces its support for prospective registration of systematic reviews during the planning stage. PLoS Medicine will now ask authors who submit reports of systematic reviews whether they registered their study and to provide a copy of the systematic review protocol if available. The Editors hope these steps will encourage and enable more transparent reporting of systematic reviews. Image Credit: James Bowe at flickr.com
Bortezomib vs. dexamethasone in relapsed multiple myeloma: A phase 3 randomized study
Authors: P. Richardson, P. Sonneveld, M. W. Schuster, D. Irwin, E. A. Stadtmauer, T. Facon, W. S. Dalton, J.-L. Harousseau, J. F. San Miguel, K. C. Anderson
Journal: Journal of Clinical Oncology (2004)

6511 Background: Bortezomib (Velcade, Millennium Pharmaceuticals), a novel proteasome inhibitor, is effective in refractory multiple myeloma (MM). For the APEX Study Group we present the interim results of an international, randomized phase 3 study conducted at 95 sites. Methods: Between June 2002 and Oct 2003 669 patients (pt) with relapsed MM previously treated with 1–3 prior therapies were randomized to bortezomib (Vc) (327 pts) 1.3 mg/m2 IV days 1,4,8,11 q 3 weeks for 8 cycles followed by 1.3 mg/m2 IV days 1,8,15,22 q 5weeks for 3 cycles versus dexamethasone (D) (330 pts) 40 mg po days 1–4, 9–12, 17–20 q 5 weeks for 4 cycles followed by 40mg po days 1–4 every 28 days for 3 cycles. The primary endpoint was time to progression (TTP) using EBMT criteria for progressive disease (PD). Secondary endpoints were overall survival (OS), incidence of ≥grade 3 infection and time to skeletal event (TSE). Pt progressing on D were offered Vc on a companion study. Results: Median age was 62 with no apparent differences in baseline characteristics. At the interim analysis (IA) 254 PD events had occurred. Pt receiving Vc demonstrated a highly significant benefit in TTP. Median TTP was 5.7 months (95% CI: 5.0, 7.9) on Vc and 3.6 months (95% CI: 3.2, 4.8) on D (p<0.0001, log-rank test). Overall survival was longer on Vc (p=0.038, log-rank test), with 13 deaths on Vc and 24 on D, but median survival was not reached on either arm. A trend towards a lower incidence of ≥grade 3 infections was also noted with 22 (6.7%) on Vc vs 35 (10.6%) on D (p=0.096, Fisher's exact test). No difference was noted in TSE (p=0.954, log-rank test). No other major safety differences were noted. Following the interim analysis, the Data Monitoring Committee recommended that treatment on the D arm be halted, and patients randomized to D were allowed to receive Vc. Conclusions: At the IA bortezomib was significantly more effective than dexamethasone for patients with relapsed MM. Further evaluation of survival, response duration, response rate, and safety are ongoing. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Millennium Pharmaceuticals Speaker's Bureau Millennium Pharmaceuticals Millennium Pharmaceuticals Millennium Pharmaceuticals Millennium Pharmaceuticals
The Exposure of Health Care Workers to Ribavirin Aerosol-Reply
Authors: Joseph Guglielmo
Journal: JAMA (1989)

<h3>In Reply.—</h3> Dr Harkness states that our recommendations would eliminate the use of ribavirin early in the course of respiratory syncytial virus infection "when clinical benefit would be expected." Marks and colleagues claim that there is a "growing database that suggests that this drug is safe and effective for children at high risk from complications due to respiratory syncytial virus." The University of California at San Francisco task force, as well as other clinicians,<sup>1</sup>came to a different conclusion, namely, that the clinical efficacy of aerosolized ribavirin is not established. The teratogenicity, mutagenicity, and embryolethal effects of ribavirin have not been observed in any primate species. Marks et al reviewed the manufacturer's data regarding the use of aerosolized ribavirin in more than 22 000 infants and noted an adverse drug reaction rate of less than 0.2%. While the retrospective analysis of Marks et al suggests that the drug is
EDITORIAL
Journal: British Journal of Sports Medicine (1984)

This morning, one of my patients, usually normotensive, had a raised blood pressure and tachycardia.He attributed this to an electricity bill he had just received, 150% higher than for the same period a year ago.This morning, I received the printer's bill, 150% higher than for the same period last yearl As paper is priced in US dollars, the balance of pound against the dollar means an increase in the price of paper of over 30% since the beginning of the year.We are also receiving many more publishable articles, some of length, so the present issue and the last have each contained 80 pages instead of the usual 48.To endeavour to keep the cost of the journal stable, we must reduce either the number of articles we publish (a disappointment to many of our authors, especially those who submit their first publication) or reduce substantially the length of articles and limit references to those most relevant to the topic.Similar reductions can already be seen in such as the British Medical Journal, World Medicine, Medical News and many others.