tbuckley/cabot-search huggingface dataset:
Investigating constipation.
Authors: E W Godding
Journal: BMJ (1980)

erythema by absorbing ultraviolet B rays.The efficacy of some of these compounds, however, is being questioned.3Some sun- screens may themselves be phototoxic7-for example, amyl dimethylaminobenzoate (Padi- mate A, Escalol 506).Some can prevent erythema, but not premalignant changes in the epidermis8 -for example, mexenone (2- hydroxy-4-methoxy-4-methylbenzophenone).Furthermore, a 5 °' ethanolic solution of para- aminobenzoic acid (PABA), though an effective sunscreen, cannot protect against druginduced phototoxic reactions. 9Broad-spectrum sunscreens combining a PABA ester with a benzophenone ester appear currently to provide the most protection from ultraviolet light. 9The Council of Europe is currently con- sidering sunscreens and one hopes that in the future proper standardisation and toxicological tests will be required for all sunscreens and tanning aids, studies which would dispel much concern regarding their safety.
If your uneaten food moves, take it to a doctor
Authors: C. D. Lane
Journal: JAMA (1988)

<h3>In Reply..—</h3> Langer and others have two criticisms of my letter regarding the possible association of fibrous tremolite with endemic pleural calcification and mesothelioma in Greece. They point out that I did not cite their article in which the hypothesis regarding the tremolite content of Metsovo whitewash was originally presented. I did, however, cite two articles by the same group of workers, including a more recent article than the one to which they refer. Second, and much more seriously, they state that I have made an error in my use of the terms<i>asbestiform</i>and<i>nonasbestiform</i>, which they have "tried to correct" in the past,<sup>1,2</sup>obviously without success. Nowhere in my most recent letter, however, did I refer to the highly elongate fibers exhibiting inclined extinction, which Langer and others call "cleavage fragments," as being asbestiform, although I consider them to be so. My use of this term in
A Medical Review of Soviet Russia: IV.--Change in Type and Incidence of Disease
Authors: W. H. Gantt
Journal: BMJ (1926)

f [-DICA JSJ belongs to the Waifs and Stravs Society, is staffed .by the ortliopaedic departm-ent of St. Tllomas's Hospital and De;.T. M. Hardy of Byfleet, wlho is the local medical officer.Members were shown round the hospital and visited the oplien-air wards, after which a clinical demonstratibn was given.A number of patients wa' exhibited,, in'cluding a group of eight cases of pseudo-coxalgia with serial radio- grams showing the various changes ov-er a* three-year -period, and for comparison two patients with flatteningof the head of the femur and cavitationi of the neck.An informal discussion was kept up) during the demonstration.A iNIED1CAL REVIEW OF SOVIET RUSSIA.'IV.
<i>The Diagnosis of incipient Melancholia</i>. An Abstract of a Lecture delivered before the Class of the Kansas City Medical College. By S. Grover Burnett, A. M., M. D.. Kansas City, Mo., Lecturer on Clinical Diseases of the Nervous System in the Kansas City Medical College. Reprinted from the <i>New York Medical Journal,</i> for May 2, 1891
Journal: American Journal of Psychiatry (1892)
Addition of Disclaimer
Journal: JAMA (2013)

Jon C. Tilburt, MD, MPH; Matthew K. Wynia, MD, MPH; Robert D. Sheeler, MD; Bjorg Thorsteinsdottir, MD; Katherine M. James, MPH; Jason S. Egginton, MPH; Mark Liebow, MD, MPH; Samia Hurst, MD; Marion Danis, MD, MPH; Susan Dorr Goold, MD, MHSA, MA
Table of Contents
Authors: Ralph Defronzo, G Fleming, Kim Chen, Thomas Bicsak, Hui Tao, Jing-Jing Yang, Kai-Hu Shi, Jun Li, Emily Graff, Han Fang, Desiree Wanders, Robert Judd, Carly Barron, Philip Bilan, Theodoros Tsakiridis, Evangelia Tsiani
Journal: Metabolism (2016)
Clinical Connections
Journal: Arthritis & Rheumatology (2017)

The role of type I interferons (IFNs) and their main cellular source, plasmacytoid dendritic cells (PDCs), in the pathogenesis of rheumatoid arthritis (RA) is a subject of controversy.Using mice genetically depleted of PDCs, Nehmar and colleagues show that these cells exhibit protective functions in arthritis induced by serum transfer.Furthermore, Toll-like receptor 7 (TLR-7)-dependent mobilization and activation of PDCs by topical application of imiquimod reduces arthritis in 3 different models of joint disease: mice with serum-transfer arthritis, collagen-induced arthritis, and human tumor necrosis factor transgene insertion.Improvement in joint pathology, as quantified by reduced expression of inflammatory cytokines and decreased bone damage, is associated with a type I IFN signature and modification of the cellular infiltrate in the joint, as characterized by reduced numbers of neutrophils in the periarticular tissue.The therapeutic action of imiquimod requires signaling through the type I IFN receptor (IFNAR), which suggests that activation of the TLR-7/PDC/IFNAR axis could provide an opportunity to improve treatment in RA patients.
Diabetes Mellitus
Authors: Samuel B. Beaser
Journal: New England Journal of Medicine (1954)

TreatmentPhysiologic difficulty in regulation of some diabetic patients with widely fluctuating blood sugar levels is sometimes called brittleness; it may actually be attributable to more than one mechanism.† It may, on the one hand, refer simply to a patient with a relatively stable carbohydrate metabolism for whom a type of insulin with unsuitable proportions of regular and long action has been prescribed. This attribute of insulin is more critical in the severer diabetes, and the result of the disharmony is an apparent lability of blood sugar. Although the convenient NPH insulin is suitable for 50 per cent of severer . . .
Campylobacter colitis.
Authors: M E Lambert, P F Schofield, A G Ironside, B K Mandal
Journal: BMJ (1979)

Eleven consecutive patients with diarrhoea from whose stools campylobacter were isolated were investigated by sigmoidoscopy and rectal biopsy. Eight had definite proctitis, and in seven biopsy specimens were abnormal with histological changes ranging from non-specific colitis to gross colitis with goblet-cell depletion and crypt-abscess formation. Nine of the patients passed blood in their stools, and in all but one abdominal pain was a feature of the illness. Severe campylobacter colitis may be clinically, sigmoidoscopically, and histologically difficult to differentiate from ulcerative colitis and is a differential diagnosis in acute colitis.
MANUAL TRAINING FOR GIRLS.
Journal: JAMA (1903)

In an address<sup>1</sup>to the graduating class of Johns Hopkins Hospital Training School for Nurses, Isabel Hampton Robb, formerly superintendent of the school, has discussed some of the defects in trained nurses. She insists that "inefficiency, superficiality and lack of thoroughness belong not to the graduate nurse alone, but are the common property of modern woman, and belong to the average American household." Out of 175 applicants for admission to our training school for nurses only forty were considered worthy. The deficiency of women in the practical knowledge of the affairs of the house is strongly emphasized. An effort is now being made in many of the more progressive training schools for nurses, both at home and abroad, to overcome, by means of a preliminary course, this deficiency as regards the care of the household and the properties of food. Desirable as this is, it is only an effort
A phase 1 dose escalation (DE) and cohort expansion (CE) study of ERY974, an anti-Glypican 3 (GPC3)/CD3 bispecific antibody, in patients with advanced solid tumors.
Authors: Yoshitaka Ogita, Daniel Weiss, Naofumi Sugaya, Mikiko Nakamura, Hajime Ito, Takahiro Ishiguro, Sumire Shimada, Masamichi Ueda, Junnosuke Matsushima, Athos Gianella-Borradori
Journal: Journal of Clinical Oncology (2018)

TPS2599 Background: ERY974 is a bispecific T cell–redirecting antibody immunotherapy that redirects T cells to tumor cells by engaging CD3 on T cells and the glypican 3 (GPC3) antigen (which is selectively expressed on tumor cells). ERY974 T cell–dependent cellular cytotoxicity has been demonstrated in vitro and transient cytokine elevations have been observed in toxicology studies (Takahiro Ishiguro et al., Sci Transl Med 2017;9:eaal4291). The primary objective of DE is to determine the maximum tolerated dose (MTD) of ERY974 in patients with locally advanced or metastatic solid tumors expressing GPC3. The primary objective of CE is to assess ERY974's preliminary anti-tumor activity. Methods: The study includes adult subjects with a life expectancy ≥ 3 months, histologically confirmed, measurable malignant solid tumors and/or metastatic disease not amenable to standard therapy, including patients with ≤ 1cm and ≤ 1 brain metastasis. Patients with interstitial lung disease, or acute/active chronic infection are excluded. ERY974 is administered IV and dosed weekly. DE occurs per an accelerated titration design (ATD), followed by a one-parameter logistic mode modified continual reassessment method (mCRM) to determine MTD (where the DLT occurrence rate is ≤ 0.25). The ATD and mCRM permit rapid dose escalation and determination of MTD while minimizing the number of subjects exposed to sub-therapeutic doses. Within DE, a flexible study design has been implemented to include a stepped increase in steroid administration and an ERY974 Fixed Day 1, Day 8 and Day 15 dosing regimen. Seven cohorts have completed without DLT and Cohort 8 began in December 2017. Additional measures will be implemented to help induce CRS tolerance. The CE will utilize a 2-stage design with futility analysis and will include the following 3 arms: GPC3+ gastric/gastroesophageal junction adenocarcinoma; GPC3+ squamous esophageal cancer; and other GPC3+ tumors. Clinical trial information: NCT02748837.
Instructions for authors
Authors: Michael Nathanson
Journal: Hepatology (2016)

Observations in Hepatology submissions are intended to be outstanding case-based contributions which describe a unique presentation, novel observation, or cutting edge approach to management of a liver disease.The format should not include an abstract.It should include a brief introduction, presentation of the case (or case series), and discussion.The maximum length is 750 words, including the summary and references.There is a maximum of 2 figures or tables, and 5 references.Observations in Hepatotoxicity are published quarterly in HEPATOL-OGY, in place of Clinical Observations.Materials published in this section are selected from submissions to Clinical Observations and are intended to be case-based novel presentations or mechanistic insights of drug or herbal and dietary supplement induced hepatotoxicity.
Phase I Trial of Plerixafor and Bortezomib as a Chemosensitization Strategy In Relapsed or Relapsed/Refractory Multiple Myeloma
Authors: Irene Ghobrial, Abdel Kareem A. Azab, Jacob P. Laubach, Ranjit Banwait, Meghan Rourke, Phong Quang, Nikhil C. Munshi, Robert L. Schlossman, Stacey Chuma, Janet Kunsman, Diane Warren, Amy Sam, Eric Still, Brittany Morgan, Kenneth C. Anderson, Paul G Richardson
Journal: Blood (2010)
Offering Advance Directives
Authors: Charles F. von Gunten
Journal: Annals of Internal Medicine (1993)

Letters1 April 1993Offering Advance DirectivesCharles F. von Gunten, MDCharles F. von Gunten, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-118-7-199304010-00029 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In the study by Schneiderman and colleagues [1], the lack of a significant difference between patients executing advance directives and those not offered the instrument may have resulted from physicians allowing patient autonomy only to the extent that they agreed with the decisions. Two recent case histories are illustrative.A 70-year-old man with a history of alcoholic cirrhosis and delirium tremens was admitted for detoxification and was prophylactically treated with a benzodiazepine. He developed a stable period of decreased responsiveness despite discontinuing benzodiazepine therapy. The attending recommended percutaneous gastrostomy feeding and placement in a nursing home. His ...REFERENCE1. Schneiderman LJ, Kronick R, Kaplan RM, Anderson JP, Langer RD. Effects of offering advance directives on medical treatments and costs. Ann Intern Med. 1992; 117:599-606. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1993Volume 118, Issue 7Page: 573-574KeywordsDetoxificationEmergency departmentGastroenterology and hepatologyIntensive care unitsIschemiaLiving willsNursing homesPalliative carePatientsVentilators Issue Published: 1 April 1993 CopyrightCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Medical News &amp;amp; Perspectives
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Compression-decompression CPR: the Biomotor
Authors: S. I. Lerman
Journal: JAMA (1994)

<h3>To the Editor.</h3> —An Editorial<sup>1</sup>in<i>JAMA</i>discusses the premature termination by the Food and Drug Administration (FDA) of trials of compression-decompression cardiopulmonary resuscitation (CPR), because of lack of informed consent. The addition of a suction phase to conventional CPR is a trivial, innocuous detail that should not require consent. The developers of the Ambu<sup>2</sup>device must certainly have tried its suction on willing volunteers and shown that its worst effect might be minor ecchymoses. In any case, the use of alternate pressure and suction for CPR is described in the August 5,1939,<i>Wiener Medizinische Wochenschrift</i>by Dr Rudolph Eisenmenger, Facharzt für physikalische Therapie, Vienna, Austria. His device, which he called a Biomotor, was a cuirass ventilator that applied alternate positive and negative air pressure to the torso, and was used extensively throughout Europe for mine rescue and other victims of asphyxia as well as polio. He urged
Periostin advances atherosclerotic and rheumatic cardiac valve degeneration by inducing angiogenesis and MMP production in humans and rodents
Authors: Daihiko Hakuno, Naritaka Kimura, Masatoyo Yoshioka, Makio Mukai, Tokuhiro Kimura, Yasunori Okada, Ryohei Yozu, Chisa Shukunami, Yuji Hiraki, Akira Kudo, Satoshi Ogawa, Keiichi Fukuda
Journal: Journal of Clinical Investigation (2010)
ADDRESS
Authors: THOMAS G. MORTON
Journal: JAMA (1897)

We are here assembled to celebrate with appropriate ceremony the opening of the latest addition to the resources of the Pennsylvania Hospital, the "Walter Garrett Memorial," designed to be occupied as a reception pavilion, a clinical, operative and lecture hall and a surgical ward for children. The managers of the hospital, ever mindful of the best interests of the institution under their care, having decided that increased facilities must be provided in order to keep pace with the modern rapid strides of improvements in surgery, one year ago authorized the construction of this building. Under the supervision and direction of Mr. Addison Hutton and Dr. Thomas S. K. Morton, this memorial building has been planned and constructed. No pains or expense have been spared in the effort to make this the equal of, if not superior to, any other structure of its description in the world. I may add that
Postdoctoral Training Program of The Institute for Cancer Research
Journal: JNCI Journal of the National Cancer Institute (1977)

Journal Article Postdoctoral Training Program of The Institute for Cancer Research Get access JNCI: Journal of the National Cancer Institute, Volume 58, Issue 4, April 1977, Page 1177, https://doi.org/10.1093/jnci/58.4.1177 Published: 01 April 1977
Unresolving Pneumonia
Authors: Reginald E. Greene
Journal: JAMA (1968)

Dr. Reginald E. Greene: A 56-year-old white man was admitted to this hospital after repeated episodes of hemoptysis over a three-month period. His illness began with fatigue, malaise, hoarseness, and cough. He ran a low-grade fever and was treated with two courses of penicillin for pneumonia. During the second course of antibiotic therapy, he noted a single episode of a dull ache in the right anterior portion of the chest. He had been a heavy smoker for years and was transiently exposed to a brother-in-law who had died of tuberculosis recently. Because of the absence of significant symptomatic improvement, he was referred to this hospital for admission. Pertinent physical findings included a normal temperature and decreased breath sounds over the right middle lobe area with crepitant rales. The findings of the remainder of the examination were normal. An intermediate strength purified protein derivative (PPD) test was strongly positive. Other laboratory
“Getting to know you and your child” screening questionnaire: Results from a Chicago pediatric collaborative.
Authors: Eugene Suh, Erika D Owen, Jennifer Reichek, Betty Roggenkamp, Julia Rachel Trosman, Tara O. Henderson, Nupur Mittal, Dipti Dighe, Asneha Iqbal, Rosa Berardi, Daniel K. Choi, Natasha Pillay Smiley, Caroline Hesko, Jason Andrew Canner, Zayda Stewart, Stacy D. Sanford, Christine B. Weldon
Journal: Journal of Clinical Oncology (2018)

e22515 Background: In 2012, a congressional symposium identified the need for services to address psychosocial issues of children with cancer. In 2013, the Institute of Medicine recommended supportive oncology services be initiated at cancer diagnosis. Chicago providers of pediatric cancer are collaborating to improve care for children with cancer and their families focusing on psychosocial stressors and quality of life. Methods: The collaborative conducted a structured review of tools: Psychosocial Assessment Tool© (PAT), Social Work Assessment Tool (SWAT), National Comprehensive Cancer Network (NCCN) Problem List, and √IN; with input from providers on stressors throughout the care continuum. The resulting screening tool was created and piloted in English and Spanish at 7 pediatric cancer hospitals. Social workers (SW) informally reported assessment of its usefulness. Results: Parents (n = 85) completed “Getting to Know You and Your Child” screening tool which inquired about caregivers, siblings, child’s interests, school, SSI/SNAP, challenges, and cultural/religious preferences. Providers reported families found the tool useful “to think about support needs.” The tool assessed 12 psychosocial stressors; the mean per patient/family was 2.4 (range 0-11). Most frequent stressors included: lack of support from friends, family, community (29%), paying for food (26%), job flexibility (26%), paying for utilities (25%), medical costs (23%), emotional support for family (22%), school concerns (21%). All who reported temporary residence also reported difficulty paying for housing (p < 0.01). Ten SWs reported this screening tool generated new insight into family structures, identified stressors and informed resolution efforts. Provider recommended adjustments to the screening tool: simplify terms for siblings, hobbies and spiritual, add pet question. Conclusions: Pilot testing of a psychosocial screening tool for pediatric and adolescent oncology informed providers of patient/family needs in a standard manner. Six of the seven pilot sites are implementing this tool as a standard practice. Preliminary data suggests patients and providers find the screener easy to use and informative.
The Injured Athlete
Authors: Letha Y. Hunter
Journal: JAMA (1983)

<i>The Injured Athlete</i>is one of the most complete sports medicine texts that I have read to date. The author has organized the contributions of a variety of sports experts, including a nutritionist, physical therapist, trainer, sports psychologist, internal medicine specialist, orthopedist, biomechanics expert, and others, so that this text is truly an overall approach to the athlete's needs rather than merely another presentation of the evaluation and treatment of athletic injuries. The first half of the text presents general considerations in sports medicine. It describes establishing an adequate prescreening history and physical examination for athletes, details the diagnosis and treatment of many medical problems often seen in athletes, and lists possible ramifications of these programs for the athlete. It presents the psychological needs of a competitive individual and introduces basic sports nutrition. A summary of the establishment of cardiovascular fitness programs and physiological conditioning programs for both children and
Madonna and Child
Authors: M. Therese Southgate
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal