tbuckley/cabot-search huggingface dataset:
FOURTH-OF-JULY INJURIES AND PROPHYLAXIS
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Free Papers
Authors: F. Blin, F. Fraïsse, P. Chauveau, P. Lahilaire, E. Boulet, R. Bouhaddi, F. Sadourny, J. Schlatter, G. Trouillet, M. Hermitte, D. Kleinknecht, F. Suarez, M. Corrales, P. González-Arenas, R. Morales, J. Sánchez, J. Esteban, M. Fernández-Guerrero, J. L. Sarasa, B. Alvarez, J. M. Caturla, J. Acosta, M. Falzoi, J. M. Carrasco, A. Ezpeleta, M. Antonelli, M. Venditti, B. Bottari, L. Riccioni, C. Montecchi, M. Coletti, M. R. Menga, M. Passariello, L. Campos, M. Palomar, B. Bermejo, J. Serra, E. Arnau, F. J. de Latorre, M. Palomar, F. Alvarez Lerma, M. A. de la Cal, J. Insausti, P. Olaechea, J. D. Edgeworth, S. J. Eykyn, R. Leach, D. F. Treacher, M. Wysocki, Y. Pean, F. Delateur, A. Rauss, F. Thomas, B. Misset, C. Cheval, T. Similowski, J. F. Timsit, M. J. Laisne, H. Mentec, T. Lazard, L. Mier, D. Dreyfuss, E. Maury, C. Lamer, P. Guerrini, C. Guérin, C. Briard, O. Kirton, B. DeHaven, J. Morgan, O. Morejon, D. Sofianou, Th. Constantinidis, M. Yannacou, E. Anastasiou, E. Sofianos, J. F. Timsit, M. Assicot, B. De Jonghe, B. Gachot, B. Regnier, J. Carlet, J. Lipman, R. Lee, L. Blumberg, S. Beards
Journal: Intensive Care Medicine (1996)
Heberden Society
Authors: Peter Heberden Of Johannesburg
Journal: Annals of the Rheumatic Diseases (1959)

a direct descendant of the Society's patron.DR.R. M. MASON (London) presented three cases.(1) The first patient was first seen in 1953 at the age of 22, complaining of painful feet which had caused him to be invalided out of the Royal Marines.The condition had been diagnosed as gout.The patient said that his feet had been painful since the age of 14, and 2 years previously he had had gonorrhoea with an associated Achilles bursitis.There was arthritis of the terminal interphalangeal joints of both big toes and tenderness of the left fourth metatarsophalangeal joint, but no other peripheral or spinal arthropathy.The erythrocyte sedimentation rate was 5 mm./hr, the Rose test was negative, and plasma uric acid estimates were 7-6, 64, 5-9, and 5 5 mg.percent.Xrays of the
Malaria: submerged awareness
Authors: K. N. Hartwig
Journal: JAMA (1996)

<h3>In Reply.</h3> —Dr Hartwig's letter emphasizes some important points raised by our article. Indeed, we agree with Hartwig that malaria continues to be a major health threat throughout much of the tropical world. The title referred to the limited and diminishing awareness of this health threat in the United States and elsewhere in the industrialized world. The goal of the article was to alert readers to this problem. The looming crisis of parasite drug resistance presents an immediate threat to everyone who experiences acute episodes of malaria, including immune adults. It is especially threatening to all nonimmune persons, including children less than 5 years of age, pregnant women, both from endemic and nonendemic areas, refugees, migrant workers, and travelers. Antimalaria drug therapy remains the primary intervention for malaria infection worldwide, and drug resistance will compromise this intervention. Malaria is not the only infectious disease for which drug resistance is emerging
A prospective analysis of hospital-acquired fever in obstetric and gynecologic patients
Authors: J. J. Klimek
Journal: JAMA (1982)

Of 2,725 obstetric and 4,090 gynecologic patients admitted to a community hospital during a 12-month period, 131 obstetric patients (4.8%) and 294 gynecologic patients (7.2%) had temperature elevations (rectal) of 38.3 °C or higher. All patients with fever were seen and followed up until discharge, and 80 different parameters were recorded for each patient, including sex, age, underlying illness, operative or diagnostic procedures, height and duration of fever, laboratory data, medications received, and ultimate cause of fever. Sixty-three obstetric patients (48%) with temperature elevations were found to have infections and fever, with skin and soft-tissue infections (59%), urinary tract infections (16%), and bacteremias (10%) being most common. Sixty-eight febrile obstetric patients (52%) were not found to have an infection. Eighty-six gynecologic patients (29%) with fever had an infection. Pelvic inflammatory disease (37%), urinary tract infection (18%), and abscess (14%) were the most common infections. Two hundred eight gynecologic patients (71%) had fever, but the exact cause of the fever in these patients remains obscure. While fever can be an early indicator of infection, it may be due to noninfectious causes in almost two thirds of hospitalized obstetric-gynecologic patients. (<i>JAMA</i>1982;247:3340-3343)
Gene Expression of Inflammatory Molecules in Circulating Lymphocytes from Arsenic-Exposed Human Subjects
Authors: Meei-Maan Wu, Hung-Yi Chiou, I-Ching Ho, Chien-Jen Chen, Te-Chang Lee
Journal: Environmental Health Perspectives (2008)

Long-term arsenic exposure is associated with an increased risk of vascular diseases including ischemic heart disease, cerebrovascular disease, and carotid atherosclerosis.The pathogenic mechanisms of arsenic atherogenicity are not completely clear.A fundamental role for inflammation in atherosclerosis and its complications has become appreciated recently.To investigate molecular targets of inflammatory pathway possibly involved in arsenic-associated atherosclerosis, we conducted an exploratory study using cDNA microarray and enzyme-linked immunosorbent assay to identify genes with differential expression in arsenic-exposed yet apparently healthy individuals.As an initial experiment, array hybridization was performed with mRNA isolated from activated lymphocytes of 24 study subjects with low (0-4.32 µg/L), intermediate (4.64-9.00µg/L), and high (9.60-46.5 µg/L) levels of blood arsenic, with each group comprising eight age-, sex-, and smoking frequency-matched individuals.A total of 708 transcripts of known human genes were analyzed, and 62 transcripts (8.8%) showed significant differences in the intermediate or high-arsenic groups compared with the low-level arsenic group.Among the significantly altered genes, several cytokines and growth factors involving inflammation, including interleukin-1 beta, interleukin-6, chemokine C-C motif ligand 2/monocyte chemotactic protein-1 (CCL2/MCP1), chemokine C-X-C motif ligand 1/growth-related oncogene alpha, chemokine C-X-C motif ligand 2/growth-related oncongene beta, CD14 antigen, and matrix metalloproteinase 1 (interstitial collagnase) were upregulated in persons with increased arsenic exposure.Multivariate analyses on 64 study subjects of varying arsenic exposure levels showed that the association of CCL2/MCP1 plasma protein level with blood arsenic remained significant after adjustment for other risk factors of cardiovascular diseases.The results of this gene expression study indicate that the expression of inflammatory molecules may be increased in human subjects after prolonged exposure to arsenic, which might be a contributory factor to the high risk of atherosclerosis in arseniasis-endemic areas in Taiwan.Further multidisciplinary studies, including molecular epidemiologic investigations, are needed to elucidate the role of arsenic-associated inflammation in the development of atherosclerosis and subsequent cardiovascular disease.
Railroad Rates for Medical Association Meeting.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Chronological Supplement to the Carcinogenic Potency Database: Standardized Results of Animal Bioassays Published through December 1982
Authors: Lois Swirsky Gold, Margarita de Veciana, Georganne M. Backman, Renae Magaw, Peggy Lopipero, Mark Smith, Mark Blumenthal, Robert Levinson, Leslie Bernstein, Bruce N. Ames
Journal: Environmental Health Perspectives (1986)

This paper is a chronological supplement to our earlier publication, "A Carcinogenic Potency Database of the Standardized Results of Animal Bioassays.¿ We report here results of carcinogenesis bioassays published in Technical Reports of the National Cancer Institute/National Toxicology Program between July 1980 and December 1982, and the general literature between July 1981 and December 1982. This supplement includes results of 280 long-term, chronic experiments of 114 test compounds, and reports the same information about each experiment in the same plot format as the earlier paper: e.g., the species and strain of test animal, the route and duration of compound administration, dose level and other aspects of experimental protocol, histopathology and tumor incidence, TD50 and its statistical significance, dose response, author's opinion about carcinogenicity, and literature reference. While a number of appendices are provided to facilitate use of this supplement, we have not duplicated here the material published earlier. Instead, we refer the reader to the earlier publications (Peto et al. and Gold et al.) for a thorough description of the numerical index of carcinogenic potency (TD50), a guide to the plot of the database, and a discussion of the sources of data, the rationale for the inclusion of particular experiments and particular target sites, and the conventions adopted in summarizing the literature. For 44 of the 114 chemicals reported in this second plot, results of earlier experiments are also given in the first plot; since only 1981-1982 results are reported here, the first plot is required for these repeated compounds. In this paper we also give corrections for errors that appeared in the earlier publication.
Sudden infant deaths may be related to retroposition of the maxilla
Journal: BMJ (1998)

Mortality is high in treated hypertensionAlthough treatment of hypertension reduces cardiovascular complications, the long term prognosis of treated hypertension is virtually unknown.For over 20 years Andersson et al (p 167) studied 686 men treated for hypertension.Compared with controls they showed a significantly increased mortality especially from myocardial infarction.The prognosis was apparent only after 10-12 years.Serum cholesterol concentration was one of the most important risk factors for dying from myocardial infarction.
Solitary pulmonary nodule in sarcoidosis
Authors: K. L. Pinsker
Journal: JAMA (1978)

ROENTGENOGRAPHIC features of pulmonary sarcoidosis include bilateral symmetrical hilar adenopathy, alveolar infiltrates, chronic upperlobe fibrosis and cavitary disease, and reticular or nodular interstitial infiltrates.<sup>1</sup>Unusual roentgenographic manifestations of this disease are giant bulla formation, multiple nodules, pleural thickening and effusion, and nonsymmetrical hilar or perihilar masses.<sup>2</sup>The solitary pulmonary nodule is a rare manifestation of pulmonary sarcoidosis. <h3>Report of a Case</h3> A 32-year-old black woman was in excellent health until she lost weight, and a nonproductive cough, malaise, and lowgrade fever developed. An intermediate-strength PPD tuberculin test had been positive for approximately ten to 15 years, without a history of isoniazid prophylaxis. She smoked two packs of cigarettes per day for approximately 15 years and has a history of sickle cell trait. The patient is from the West Indies and has no history of recent travel to any area of endemic fungal disease. Her vital signs were normal,
Computer Crutches
Authors: Rudolph H. de Jong
Journal: JAMA (1978)

As an editor, my bile rises whenever I come across the words "the data were analyzed by computer." That assertion gives me the uncomfortable feeling that the author questions his own data and hides behind the computer to still his doubts and, presumably, those of the reader. Other authors turn to the computer to clothe results in pseudoscientific respectability— often going to ludicrous ends such as performing multivariate analysis of responses to a questionnaire with a 40% reply rate or calculating percentages to four decimal places, to cite two recent examples. There is an old (as computers go) aphorism "garbage in, garbage out." The meaning is evident: if your data base is shaky, no amount of fancy computation will shore up the end product. Computer analysis merely eases and speeds the drudgery of computation; it does nothing for ordinary statistics that you cannot do with an inexpensive electronic calculator or
Incidence of adverse reactions to cyclosporine after liver transplantation is predicted by the first blood level
Authors: D Azoulay
Journal: Hepatology (1993)

Despite the availability of whole-blood cyclosporine assays, the different responses of individual patients to its administration after transplantation continue to pose clinical problems, particularly with respect to toxicity. Fifty-seven recipients of first orthotopic liver transplants were studied between January 1992 and July 1992. Initial immunosuppression was carried out with azathioprine, methylprednisolone and cyclosporine, at a dose of 1 mg/kg/day adjusted to achieve blood levels between 400 and 600 ng/ml. Cyclosporine levels were measured 12 hr after the start of intravenous administration and correlated with the occurrence of toxic complications. Twelve patients experienced toxic complications in the first 7 days after orthotopic liver transplantation. These were neurological in six patients (of whom four also had kidney failure) and renal complications in the other six patients. All complications were reversed by reducing or stopping administration of cyclosporine. We noted excellent correlation between the occurrence of complications and cyclosporine whole-blood levels (p < 0.0001) despite the fact that levels did not exceed the therapeutic range. However, no correlation was observed between toxicity and cumulative dosage. In this study we were able to demonstrate that a standardized dose of cyclosporine does not prevent the occurrence of toxic side effects even when cyclosporine whole-blood levels are subsequently maintained in the therapeutic range. This highlights the importance of the first dose of cyclosporine and consequent early postoperative blood levels and indicates that these problems are unlikely to be overcome until a method of predicting individual requirements can be established in clinical practice. (HEPATOLOGY 1993;18:1123–1126.)
DISSECTING THE MOLECULAR PROFILES IN DIFFUSE LARGE B-CELL LYMPHOMA USING THE RNA- AND PROTEIN-BARCODED NCOUNTER METHOD
Authors: C.-C. Chen, C.-C. Hsu, C.-E. Huang, Y.-J. Chen, Y.-Y. Chen, Y.-Y. Wu, H.-Y. Tsou, P.-W. Tsai, C.-P. Li, W.-H. Chuang, Y.-H. Lai, Y.-H. Lin
Journal: HemaSphere (2019)
In apparent Poliomyelitis Infection in Two Neighboring Groups of Infants and Children Previously Vaccinated Subcutaneously: I. Epidemiologic Study of Viral Diffusion
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Graham Lusk (1866-1932). Nutrition Scientist
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 109: PI3Kγ Regulates Release of Myocyte-derived Factors Responsible for Myofibroblast Differentiation and Cardiac Fibrosis
Authors: Maradumane L Mohan, Lisa M Grove, Robert S Papay, Elizabeth E Martelli, Belinda B Willard, Mitchell A Olman, Sathyamangla V Naga Prasad
Journal: Circulation Research (2017)

Phosphoinositide 3 Kinase γ (PI3Kγ) is a lipid kinase that regulates downstream anti-apoptotic Akt signaling. Thus, pressure overload in PI3Kγ null (PI3Kγ -/- ) mice leads to significant cardiac fibrosis, a key underlying cause of fatal heart failure. Classical hallmark of tissue fibrosis is differentiation of fibroblasts to myofibroblasts characterized by smooth muscle α-actin (αSMA) overexpression. However, less is known about the role of PI3Kγ in cardiac myofibroblast differentiation. Assessment of αSMA expression in cardiac lysates from WT and PI3Kγ -/- showed significant baseline upregulation in PI3Kγ -/- showing that loss of PI3Kγ predisposes the hearts towards fibrosis. To directly confirm that PI3Kγ -/- cardiac fibroblasts (CF) exhibit a myofibroblast phenotype, CF were isolated from hearts of WT and PI3Kγ -/- and assessed by immunostaining for αSMA in stress fibers. Greater number of CF from PI3Kγ -/- exhibited αSMA in stress fibers than CF from WT. Correspondingly, immunoblotting showed significantly higher expression of αSMA in PI3Kγ -/- CF compared to WT showing enhanced myofibroblast differentiation by PI3Kγ -/- fibroblasts. Surprisingly, abundance of αSMA protein is significantly reduced in the hearts of mice with cardiomyocyte-specific expression of kinase-dead PI3Kγ (PI3Kγ inact ) in the PI3Kγ -/- (PI3Kγ inact /PI3Kγ -/- ) suggesting that myocytes derived factors responsible for myofibroblast differentiation are regulated by kinase-independent function of PI3Kγ. To directly evaluate the PI3Kγ-dependent cardiomyocyte derived factors responsible for myofibroblast differentiation; fibroblasts were treated with conditioned media derived from primary adult cardiomyocytes from WT, PI3Kγ -/- and PI3Kγ inact /PI3Kγ -/- mice. Conditioned media derived from PI3Kγ -/- showed pro-fibrotic effects, while that from PI3Kγ inact /PI3Kγ -/- showed fibrosis protective biological activity compared to WT. These findings reveal that kinase-independent function of PI3Kγ is a key regulator of the myocyte-initiated pathway that ultimately drives myofibroblast conversion. Proteomic analysis of conditioned media identified several pro-fibrotic factors that are regulated by PI3Kγ, the results of which will be discussed.
Renal tranplantation in type 1 glycogenosis. Failure to improve glucose metabolism
Authors: M. Emmett
Journal: JAMA (1978)

In glycogenosis type 1 (GT1), glucose synthesis is deficient due to absence of glucose-6-phosphatase. Development of renal failure in such a patient provided the opportunity to test whether or not this metabolic defect could be reversed by a renal allograft, which contains the missing enzyme and has potential for glucose synthesis. Despite normalization of renal function and both glucocorticoid therapy and the infusion of amino-acid precursors of glucose, fasting hypoglycemia persisted unabated. We conclude that a functioning renal allograft is incapable of meeting the metabolic demands of a patient with glucose-6-phosphatase deficiency. (<i>JAMA</i>239:1642-1644, 1978)
Obstruction of vertebral artery in a 43-year-old man
Authors: R. Jankowski
Journal: JAMA (1981)

<h3>History</h3> A 43-year-old man was admitted to the hospital with a one-day history of lethargy, severe headache, and difficulties in gait. Physical examination demonstrated midbrain and tectum dysfunction. Spinal fluid was xanthochromic, with 320,000 RBCs per cubic millimeter. An arteriovenous malformation in the region of the tectum and quadrigeminal plate was identified on a computed tomographic study. A selective left vertebral injection was performed with the patient's head turned to the right for the lateral view and demonstrated complete occlusion of the left vertebral artery (Fig 1). <h3>Diagnosis</h3> Transient rotational obstruction of vertebral artery associated with high flow. <h3>Comment</h3> The vertebral angiogram was repeated with the head of the patient straightened and demonstrated patency of the enlarged left vertebral artery and also outlined a large arteriovenous malformation in the posterior fossa (Fig 2). Many causes have been cited for extrinsic occlusion of the vertebral artery below the level of C2,