tbuckley/cabot-search huggingface dataset:
Assessing Exposure to Disinfection By-Products in Women of Reproductive Age Living in Corpus Christi, Texas, and Cobb County, Georgia: Descriptive Results and Methods
Authors: Michele Lynberg, J. R. Nuckols, Peter Langlois, David Ashley, Philip Singer, Pauline Mendola, Charles Wilkes, Heidi Krapfl, Eileen Miles, Vanessa Speight, Bruce Lin, Leanne Small, Amy Miles, Michael Bonin, Perri Zeitz, Altaf Tadkod, Judy Henry, Mathias B. Forrester
Journal: Environmental Health Perspectives (2001)

We conducted a field study in Corpus Christi, Texas, and Cobb County, Georgia, to evaluate exposure measures for disinfection by-products, with special emphasis on trihalomethanes (THMs). Participants were mothers living in either geographic area who had given birth to healthy infants from June 1998 through May 1999. We assessed exposure by sampling blood and water and obtaining information about water use habits and tap water characteristics. Two 10-mL whole blood samples were collected from each participant before and immediately after her shower. Levels of individual THM species (chloroform, bromodichloromethane, dibromochloromethane, and bromoform) were measured in whole blood [parts per trillion (pptr)] and in water samples (parts per billion). In the Corpus Christi water samples, brominated compounds accounted for 71% of the total THM concentration by weight; in Cobb County, chloroform accounted for 88%. Significant differences in blood THM levels were observed between study locations. For example, the median baseline blood level of bromoform was 0.3 pptr and 3.5 pptr for participants in Cobb County and Corpus Christi, respectively (p = 0.0001). Differences were most striking in blood obtained after showering. For bromoform, the median blood levels were 0.5 pptr and 17 pptr for participants in Cobb County and Corpus Christi, respectively (p = 0.0001). These results suggest that blood levels of THM species vary substantially across populations, depending on both water quality characteristics and water use activities. Such variation has important implications for epidemiologic studies of the potential health effects of disinfection by-products.
THE VERMONT STATE MEDICAL SOCIETY.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 1524: CD137 (4-1BB) engagement fine-tunes the synergistic IL-15- and IL-21-driven NK cell proliferation
Authors: Laurent Vidard, Christine Dureuil-Sizaire, Jérémy Baudhuin, Lionel Vescovi, Laurence Durand, Véronique Sierra, Eric Parmantier
Journal: Cancer Research (2019)

Abstract To understand and dissect the mechanisms driving NK cell proliferation, we took advantage of the methodology used in cell therapy to numerically expand NK cells in the presence of K562-derived artificial Antigen Presenting Cells (aAPCs) and cytokines. For 9 consecutive weeks, high expression of CD137L by a K562-derived aAPC cell line was able to sustain NK cell expansion by 100 million-fold whereas low expression of CD137L by the parental K562 cell line supported the expansion by only 40,000-fold. The level of expression of CD137L, however, did not modulate the sensitivity of the K562 cell line to the intrinsic cytotoxicity of NK cells. Similarly, the low NK cell proliferation in the presence of the parental K562 cell line and cytokines was increased by adding agonistic anti-CD137 antibodies to levels similar to CD137L-expressing K562-derived aAPCs. Finally, the synergy between IL-15 and IL-21 was observed only upon CD137 engagement and the presence of aAPCs. Therefore, we conclude that NK cell proliferation requires cell-to-cell contact, the activation of CD137 axis, the presence of IL-15 (or its membranous form) and IL-21. By analogy with the three signals model required to activate T cells, we speculate, that the cell-to-cell contact represents “signal 1”, CD137 would be “signal 2” and cytokines would be “signal 3”. The precise nature of signal 1 remains to be defined. Citation Format: Laurent Vidard, Christine Dureuil-Sizaire, Jérémy Baudhuin, Lionel Vescovi, Laurence Durand, Véronique Sierra, Eric Parmantier. CD137 (4-1BB) engagement fine-tunes the synergistic IL-15- and IL-21-driven NK cell proliferation [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1524.
DIABETIC RETINITIS
Authors: HARRY FRIEDENWALD
Journal: JAMA (1925)

The teaching of Hirschberg concerning the retinal manifestations of diabetes early impressed me with the peculiar affection in the central region of the retina, consisting of small, bright, white spots with fine hemorrhages, the retinitis centralis punctata diabetica. Soon after the publication of Hirschberg's<sup>1</sup>paper in 1890, I<sup>2</sup>reported a case of this kind, and it has been my habit, in practice, to look on these findings as suggestive of diabetes. This is, indeed, the view generally accepted, and almost every publication since 1890 dealing with this subject quotes Hirschberg's description. This is the course that has also been followed by Leber<sup>3</sup>in his work on "Diseases of the Retina," and by Dimmer.<sup>4</sup> The probable dependence of this form of retinitis, as well as others, on primary vascular changes led Wilbrand and Saenger<sup>5</sup>to discard the name retinitis and substitute for it "angiopathy of the
Silencing HBV expression using LNA gapmers: preliminary data of a new promising strategy
Authors: Maria Francesca Cortese, Rosario Casillas, Ester García-Pras, Mireia García-López, Rosa Lopez-Martinez, Cristina Godoy Cruz, David Tabernero, Sara Sopena, Marçal Yll, Ariadna Rando, Mar Riveiro Barciela, Sofía Pérez-del-Pulgar, Maria Buti, Francisco Rodríguez-Frías
Journal: Journal of Hepatology (2020)
Trimethoprim-induced aseptic meningitis
Authors: S. J. Derbes
Journal: JAMA (1984)

ASEPTIC meningitis has been described in association with the administration of anti-inflammatory drugs, including ibuprofen, sulindac and tolmetin sodium, and azathioprine.<sup>1-4</sup>Most, but not all, of the patients reported have had either systemic lupus erythematosus (SLE) or mixed connective-tissue disease.<sup>5,6</sup>Sulfamethizole-induced meningitis and pancreatitis have been described in a patient who was ostensibly free of underlying chronic disease.<sup>7</sup>More recently, aseptic meningitis has been associated with the use of trimethoprim-sulfamethoxazole.<sup>8</sup>This report describes a patient with Sjögren's syndrome who had four episodes of aseptic meningitis temporally related to the use of trimethoprim-sulfamethoxazole, and a single episode of aseptic meningitis following the use of trimethoprim alone. <h3>Report of a Case</h3><h3>First Admission.—</h3> A 61-year-old diabetic woman was hospitalized in June 1979 with a two-day history of fever, headache, nausea, and myalgias. Three years previously, she had complained of hair loss, arthralgias, and dryness of the eyes and
Intrathecal morphine for intraoperative and postoperative analgesia
Authors: A. Tung
Journal: JAMA (1980)

INTRATHECAL morphine injection for relief of cancer pain was recently shown by Wang et al<sup>1</sup>to be effective and safe. To our knowledge, its use for intraoperative and postoperative analgesia has not been reported. <h3>Report of a Case</h3> A 52-year-old man was admitted to the Presbyterian-University Hospital, Pittsburgh, and referred to the Pain Control Clinic in January 1980 for treatment of abdominal pain. A diagnosis of inoperable carcinoma of the pancreas had been confirmed at laparotomy six months earlier. His pain occurred mainly on the right side of the abdomen and had increased in severity to the extent that he required an intramuscular (IM) injection of morphine sulfate, 10 mg every four hours, for control of the pain. Since this patient's condition had been diagnosed as terminal cancer, he was included in a clinical trial involving the use of intrathecal morphine for pain relief. On two separate occasions (three
MNGO-01A PROGNOSTIC CYTOGENETIC SCORING SYSTEM TO GUIDE THE ADJUVANT MANAGEMENT OF PATIENTS WITH ATYPICAL MENINGIOMA
Authors: Malak Abedalthagafi, Ayal Aizer, Wenya Linda Bi, Margaret Horvath, Nils Arvold, Ossama Al-Mefty, Eudocia Lee, Lakshmi Nayak, Mikael Rinne, Andrew Norden, David Reardon, Patrick Wen, Keith Ligon, Azra Ligon, Rameen Beroukhim, Ian Dunn, Sandro Santagata, Brian Alexander
Journal: Neuro-Oncology (2015)
Law and Medicine
Authors: Lawrence O. Gostin
Journal: JAMA (1994)

On October 27, 1993, President Clinton presented to the 103rd Congress the National Health Security Act to "ensure individual and family security through health care coverage for all Americans." Innumerable legal issues are presented by the bill, but the first portion of this review focuses on two<sup>1</sup>: (1) What exactly is an eligible individual entitled to under the bill? (2) How can hospitals and groups of health care professionals compete in a manner consistent with extant antitrust law? Eligible individuals are entitled to "medically necessary or appropriate" services under the comprehensive benefits package (section 1141). While the National Health Board is empowered to exclude specific services (section 1154), many determinations as to whether patients can be denied costineffective treatments will be determined by the courts. Although it was considered by the task force, a fair and effective administrative remedy for patients denied treatment was not included in the bill.
"Ulcus Penis."
Authors: F. P. Nichols
Journal: BMJ (1892)

<h3>Abstract</h3> There is an ongoing debate as to whether cognitive processes arise from a group of functionally specialized brain modules (modularism) or as the result of a distributed nonlinear process (dynamical systems theory). The former predicts that tasks that recruit similar brain areas should have an equivalent degree of similarity in their connectivity. The latter allows for differential connectivity, even when the areas recruited are largely the same. Here we evaluated both views by comparing activation and connectivity patterns from a large sample of healthy subjects (N=242) that performed two executive control tasks, color-word Stroop task and Multi-Source Interference Task (MSIT), known to recruit similar brain areas. Using a measure of instantaneous connectivity based on edge time series as outcome variables, we estimated task-related network profiles as connectivity changes between incongruent and congruent information conditions. The degree of similarity of such profiles at the group level between both tasks was substantially smaller than their overlapping activation responses. A similar finding was observed at the subject level and when employing a different method for defining task-related connectivity. Our results are consistent with the perspective of the brain as a dynamical system, suggesting that task representations should be understood at both node and edge (connectivity) levels. <h3>Significance Statement</h3> There exist two contrasting views of the brain that yield different predictions of how cognition is represented. In the modular view, similar cognitive processes should have similar connectivity profiles. In contrast, a dynamical systems view allows for multiple network configurations in these situations. Here we tested both views using two tasks, color-word Stroop and Multi-Source Interference Task (MSIT), that evoke a similar brain response. Using a novel approach of instantaneous connectivity we first estimated the connectivity changes during both tasks and subsequently found that their similarity was substantially smaller than the patterns of brain activation. These findings reinforce the view of brain as a dynamical system and shed light onto how cognitive processes may be quantitatively modeled.
Overall Survival (OS) with Afatinib (A) Vs Chemotherapy (CT) in Patients (PTS) with Nsclc Harbouring EGFR Mutations (MUT): Subgroup Analyses by Race in Lux-Lung 3 (LL3) and Lux-Lung 6 (LL6)
Authors: M. Schuler, J.C.-H. Yang, L.V. Sequist, N. Yamamoto, C. Zhou, C.-P. Hu, K. O'Byrne, V. Hirsh, T.S.K. Mok, Y.-L. Wu
Journal: Annals of Oncology (2015)
Pemoline Abuse
Authors: Susan E. Polchert
Journal: JAMA (1985)

Addictive use of the stimulant drug pemoline caused a delusional disorder in a middle-aged man. Discontinuance of use of the drug promptly reversed the psychosis, which subsequently recurred when pemoline was again used. Pemoline seems to be an addictive drug and has an additional property that heretofore has been attributed mainly to amphetamines— precipitation of a paranoid psychosis. (<i>JAMA</i>1985;254:946-947)
Transcriptional and posttranslational regulation of cre recombinase by ru486 as the basis for an enhanced inducible expression system
Authors: S Kyrkanides
Journal: Molecular Therapy (2003)

Genetic studies often require the employment of an inducible expression system, whereby the expression of a particular gene can be regulated by the exogenous administration of an inert ligand. Cre/loxP-based systems have been previously described as the basis for inducible expression systems by exerting site-specific DNA recombination. In our effort to enhance the properties of the RU486-responsive CrePr1 construct, we have developed the dual GLVP/CrePr system, in which RU486 confers activity control at both the transcriptional and the posttranslational level of CrePr1. This was achieved by placing CrePr1 transcriptional regulation under the control of the RU486-sensitive chimeric regulator GLVP. Stable cell lines harboring the dual GLVP/CrePr as well as the single CrePr1 system were developed. Our results indicate that the dually regulated system is highly inducible by RU486 while maintaining minimal basal activity (“leakage”), characteristics that can be employed in the development of transgenic mice in which genetic pathways can be turned on or turned off after exogenous administration of RU486 at physiologically inert doses.
Gene expression panel (TheraPrint) analyzed as predictors of response to neoadjuvant chemotherapy (NCT) in patients (pts) with stage II-III and inflammatory breast cancer (BC).
Authors: George Somlo, Femke De Snoo, Justine Peeters, Lisette Stork-Sloots, Iris Simon, Kim Robinson
Journal: Journal of Clinical Oncology (2012)

8 Background: TheraPrint is a microarray-based gene expression panel of 125 genes identified as potential targets for prognosis and therapeutic response. These genes may hold the key to a greater level of personalized prognosis and therapy for BC pts. The aim of the current study was to assess the clinical relevance of the TheraPrint genes for either predictive and/or prognostic value in two patient cohorts treated with NCT. Methods: The 1st patient cohort are 68 Stage II-III BC pts treated with NCT. Expression data from Agilent full genome arrays, containing the MammaPrint, BluePrint and TheraPrint diagnostic profiles/probes (Somlo et al, 2009). Median FU 2.3 years. The 2nd patient cohort are 230 Stage I-III BC pts treated with NCT. Expression data from Affymetrix probe sets was publically available (Iwamoto et al, 2011). Median FU 5.2 years. To identify genes that are differentially expressed between responders (pCR/RCBI) and non-responders, a supervised analysis was performed. The analysis was performed across all pts and also within groups of HER2+ and HER2-. Univariate t-tests were performed, with results filtered by permutation p-value (p&lt;0.05) and fold change of &gt;1.5. Global test was also reported. In addition, survival data analysis was performed across all pts. Results: Overlapping genes between the 2 datasets that were significantly differentially expressed between responders and non-responders include: BCL2 (down-regulated) and CDH3, GRB7, KRT6B, KRT17 (up-regulated). When analysing the HER2- subgroup, 3 genes turned out to be differentially expressed between responders and non-responders in the 2 datasets: FLT1, PIK3R1 (down-regulated) and KRT6B (up-regulated). For the HER2+ subgroup, only one gene overlapped for the 2 datasets: IL2RA (up-regulated). The top canonical pathways for the significant genes have been analyzed, and in addition correlation of the TheraPrint gene expression with survival for these pt groups. Conclusions: This study has identified several genes from a panel of 125 TheraPrint genes with statistically significant correlation between expression and response to NCT.
Reduction of Trace but Not Delay Eyeblink Conditioning in Panic Disorder
Authors: Christian Grillon
Journal: American Journal of Psychiatry (2007)

Objective: Individuals with panic disorder perceive panic attacks as unpredictable. Because predictability is fundamental to Pavlovian conditioning, failure to predict panic attacks could be due to a basic deficit in conditioning. The present study examined trace eyeblink conditioning in order to test the hypothesis that individuals with panic disorder are impaired in associative learning tasks that depend on declarative memory. Method: Delay and trace eyeblink conditioning were tested in separate experimental sessions in 19 individuals meeting DSM-IV criteria for panic disorder and 19 sex- and age-matched healthy comparison subjects. In the delay paradigm, a mild puff was delivered to the eye at the end of a 500-msec tone; in the trace paradigm, the puff was delivered after a 700-msec empty "trace" interval that followed the end of the tone. Results: Patients and comparison subjects showed similar rates of conditioned responses in the delay paradigm, but patients showed reduced rates of conditioned responses in the trace paradigm. Conclusions: These results suggest that individuals with panic disorder suffer from a deficit in declarative associative learning. Such a deficit points to impaired hippocampal function that may disrupt cognitive processing of internal and external cues predictive of a panic attack.
HAH—CHOOO!
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prevalence of Oligoclonal Bands in Multiple Myeloma Patients Who Achieved Better Results Than Very Good Partial Response after Treatment with Standard or High Doses Chemotherapy-Final Analysis
Authors: Luiza soares Vieira, Edvan de queiroz Crusoe, Manuella de S. Sampaio Almeida, Lais Sousa, ana Lucia Perez, Priscilla Cury, Marina Rossato, Fabiana Higashi, ana Luiza Dias, anna Carolina Castro, Carlos Chiattone, Vania T M Hungria
Journal: Blood (2015)
Predictive value of sentinel lymph node biopsy prior to neoadjuvant chemotherapy in clinically node negative breast cancer
Authors: J. L. Jones, E. Rhei, M. A. Gadd, M. Howard-Mcnatt, K. S. Hughes, B.-A. Lesnikoski, R. L. Christian, J. T. Rabban, C. Kaelin, B. L. Smith
Journal: Journal of Clinical Oncology (2004)

606
Methylene Blue To Treat Hepatopulmonary Syndrome
Journal: Annals of Internal Medicine (2000)

Summaries for Patients7 November 2000Methylene Blue To Treat Hepatopulmonary SyndromeSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-133-9-200011070-00007 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Hepatopulmonary syndrome is a serious condition that involves lung abnormalities in patients with liver disease. These abnormalities result in abnormally low oxygen levels in the blood. Within 3 years of developing hepatopulmonary syndrome, 41% of patients will die. No effective treatment is available for this condition. One aspect of hepatopulmonary syndrome is the abnormal widening of the blood vessels in the lung (pulmonary vasodilatation), which allows blood to flow through the lungs rapidly. The rapidly flowing blood picks up too little oxygen. It is thought that drugs that ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Methylene Blue Improves the Hepatopulmonary Syndrome.” It is in the 7 November 2000 issue of Annals of Internal Medicine (volume 133, pages 701-706). The authors are P Schenk, C Madl, S Rezaie-Majd, S Lehr, and C Müller.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. Previousarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoMethylene Blue Improves the Hepatopulmonary Syndrome Peter Schenk , Christian Madl , Shahrzad Rezaie-Majd , Stephan Lehr , and Christian Müller Metrics 7 November 2000Volume 133, Issue 9Page: I-9KeywordsBloodBlood vesselsDrugsIntensive care unitsLiver diseasesLungsMethylene blueOxygenVasodilationVeins ePublished: 7 November 2000 Issue Published: 7 November 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...