<i>In vitro</i> methods for quantifying IgE antibodies to betalactams
Authors: M. Blanca, M. J. Torres, C. Mayorga, A. Romano, E. Perez‐Inestrosa, R. Suau
Journal: Allergy (1999)

AllergyVolume 54, Issue s58 p. 8-12 Full Access In vitro methods for quantifying IgE antibodies to betalactams M. Blanca, Corresponding Author M. Blanca Research Unit for Allergic Diseases, Carlos Haya University Hospital, Malaga, SpainAllergy Laboratory Carlos Haya Hospital Avd Carlos Haya s/n 29010-Malaga Spain Fax: +34 52 28 73 40Search for more papers by this authorM. J. Torres, M. J. Torres Research Unit for Allergic Diseases, Carlos Haya University Hospital, Malaga, SpainSearch for more papers by this authorC. Mayorga, C. Mayorga Research Unit for Allergic Diseases, Carlos Haya University Hospital, Malaga, SpainSearch for more papers by this authorA. Romano, A. Romano Department of Internal Medicine and Geriatrics, UCSC, C. I. Columbus, Rome and IRCCS Oasi Maria S. S., Troina, ItalySearch for more papers by this authorE. Perez-Inestrosa, E. Perez-Inestrosa Organic Chemistry Department, Faculty of Sciences, Malaga, SpainSearch for more papers by this authorR. Suau, R. Suau Organic Chemistry Department, Faculty of Sciences, Malaga, SpainSearch for more papers by this author M. Blanca, Corresponding Author M. Blanca Research Unit for Allergic Diseases, Carlos Haya University Hospital, Malaga, SpainAllergy Laboratory Carlos Haya Hospital Avd Carlos Haya s/n 29010-Malaga Spain Fax: +34 52 28 73 40Search for more papers by this authorM. J. Torres, M. J. Torres Research Unit for Allergic Diseases, Carlos Haya University Hospital, Malaga, SpainSearch for more papers by this authorC. Mayorga, C. Mayorga Research Unit for Allergic Diseases, Carlos Haya University Hospital, Malaga, SpainSearch for more papers by this authorA. Romano, A. Romano Department of Internal Medicine and Geriatrics, UCSC, C. I. Columbus, Rome and IRCCS Oasi Maria S. S., Troina, ItalySearch for more papers by this authorE. Perez-Inestrosa, E. Perez-Inestrosa Organic Chemistry Department, Faculty of Sciences, Malaga, SpainSearch for more papers by this authorR. Suau, R. Suau Organic Chemistry Department, Faculty of Sciences, Malaga, SpainSearch for more papers by this author First published: 03 March 2009 https://doi.org/10.1111/j.1398-9995.1999.tb04741.xCitations: 3AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1 de Weck AL. Immunopathological mechanisms and clinical aspects of allergic reactions to drugs. In: AL Week, H Bundgaard, editors. Allergic reactions to drugs. Berlin : Springer, 1983; 75–133. 2 de Weck AL. Penicillins and cephalosporins. In: AL Week, H Bundgaard, editors. Allergic reactions to drugs. Berlin : Springer 1983; 423–482. 3 Dewdney JM. Immunology of the antibiotics. In: M Sela, editor. The antigens. Vol. 5. New York : Academic Press, 1977; 73–245. 4 Kraft D, Berglund A, Rumpold H, Roth A, Ebner H. Radioallergosorbent test with conjugates specific for "minor" haptenic determinants in the diagnosis of IgE-mediated penicillin allergy in man. Clin Allergy 1981; 11: 579–587. 5 Parker CW. Allergic reactions in man. Pharmacol Rev 1982; 34: 85–104. 6 Levine BB, Price VH. Studies on the immunological mechanisms of penicillin allergy. II. Antigenic specificities of allergic wheal-and-flare skin responses in patients with histories of penicillin allergy. Immunology 1964; 7: 542–551. 7 Wide L, Bennich H, Johansson SGO. Diagnosis of allergy by an in vitro test for allergen antibodies. Lancet 1967; 2: 1105–1107. 8 Wide L, Juhlin L. Detection of penicillin allergy of the immediate type by radioimmunoassay of reagins (IgE) to penicilloyl conjugates. Clin Allergy 1971; 1: 171–176. 9 Edwards RG, Spackman DA, Dewdney JM. Development and use of three new radioallergosorbent tests in the diagnosis of penicillin allergy. Int Arch Allergy Appl Immunol 1982; 68: 352–357. 10 Blanca M, Mayorga C, Pérez E, et al. Determination of IgE antibodies to the benzylpenicilloyl determinant:a comparison between poly-L-lysine and human serum albumin as carriers. J Immunol Methods 1992; 153: 99–105. 11 Daxun Z, Adriansson J, Martin A, Malmberg E, Ahlstedt S. Diagnostic capabilities of penicillin-based structures as tools in the in vitro diagnosis of penicillin allergy. J Investig Allergol Clin Immunol 1992; 2: 240–246. 12 Blanca M, Moreno F, Mayorga C, et al. The nature of the carrier in the RAST assay influences the capacity for detecting IgE antibodies to penicillins. J Clin Immunoassay 1994; 17: 166–170. 13 Garcia JJ, Blanca M, Moreno F, et al. Determination of IgE antibodies to the benzylpenicilloyl determinant:a comparison of the sensitivity and specificity of three radioallergosorbent test methods. J Clin Lab Anal 1997; 11: 251–257. 14 Levine BB, Ovary Z. Studies of the mechanism of the formation of the penicillin antigen. III. The N(D-(benzyl penicilloyl) group as an antigenic determinant responsible for hypersensitivity to penicillin G. J Exp Med 1961; 114: 875–904. 15 Levine BB, Redmond AP. Minor haptenic determinant specific reagins of penicillin hypersensitivity in man. Int Arch Allergy Appl Immunol 1969; 35: 445–455. 16 Weiss ME, Adkinson NF. Immediate hypersensitivity reactions to penicillin and related antibiotics. Clin Allergy 1988; 18: 515–540. 17 Kraft D, Roth A, Mischer P, Pichler H, Ebner H. Specific and total serum IgE measurements in the diagnosis of penicillin allergy. A long term follow-up study. Clin Allergy 1977; 7: 21–28. 18 Yvon M, Anglade P, Wal JM. Identification of the binding sites of benzylpenicilloyl, the allergenic metabolite of penicillin, on the serum albumin molecule. J Clin Invest 1990; 263: 237–240. 19 Lafaye P, Lapresle C. Location of penicilloyl groups on CNBr fragments of the albumin from penicillin treated patients. FEBS Lett 1987; 220: 206–208. 20 Bootello A, Moneo I, Cuevas M, Alvarez E. Detectión de anticuerpos antipenicilina:correlación entre la técnica de RAST y el enzimoinmunoanalisis a doble paso. Allergol Immunopathol (Madr) 1980; 7: 297–300. 21 Klein GF, Stanzl U, Fritsch PO, Varga JM. Enzyme-linked immunosorbent assay for detection of antibodies to the unmodified beta-lactam ring. Allergy 1993; 48: 151–157. 22 Blanca M, Carmona MJ, Moreno F, Mayorga C, Garcia J. Selective immediate allergic response to penicillin V Allergy 1999; 51: 961–963. 23 Romano A, Torres MJ, Fernandez J, et al. Allergic reactions to ampicillin. Studies of the specificity and selectivity in subjects with immediate reactions. Clin Exp Allergy 1997; 27: 1425–1431. 24 Blanca M, Vega JM, Garcia J, et al. Allergy to penicillin with good tolerance to other penicillins. Study of the incidence in patients allergic to betalactams. Clin Exp Allergy 1991; 20: 475–481. 25 Audicana M, Bemaola G, Urrutia I, et al. Allergic reactions to betalactams:studies in a group of patients allergic to penicillin and evaluation of cross-reactivity with cephalosporin. Allergy 1994; 49: 108–113. 26 Martin JA, Igea JM, Fraj J, Lezaun A, Parra F, Losada E. Allergy to amoxicillin in patients who tolerated benzylpenicillin, aztreonam and ceftazidime. Clin Infect Dis 1992; 14: 592–593. 27 Silviu Dan F, McPhiliphs S, Warrington R. The frequency of skin test reactions to side chain penicillin determinants. J Allergy Clin Immunol 1993; 91: 694–701. 28 Baldo B, Pham NH. Detection and side-chain specificity of IgE antibodies to flucloxacillin in allergic subjects. J Mol Recognit 1995; 8: 1–7. 29 Igea JM, Fraj J, Davila I, Cuevas M, Cuesta J, Hinojosa M. Allergy to cefazolin:study of in vivo cross reactivity with other betalactams. Ann Allergy 1992; 68: 515–519. 30 Marcos Bravo C, Luna Ortiz I, González Vázquez R. Hypersensitivity to cefuroxime with good tolerance to other betalactams. Allergy 1995; 50: 359–361. 31 Romano A, Quaratino D, Aimone-Gastin I, et al. Cephalosporin allergy:characterization of unique and cross-reacting cephalosporin antigens. Int J Immunopathol Pharmacol 1997; 10: 187–191. 32 Fernandez Rivas M, Perez Canal C, Cuevas M, Marti C, Moral A, Senent CJ. Selective allergic reactions to clavulanic acid. J Allergy Clin Immunol 1995; 95: 748–750. 33 Blanca M, Vega JM, Garcia JJ, et al. New aspects of allergic reactions to betalactams. Cross-reactions and unique specificities. Clin Exp Allergy 1994; 24: 407–415. 34 Romano A, Quaratino D, Venuti A, Venemalm L, Mayorga C, Blanca M. Selective type-1 hypersensitivity to cefuroxime. J Allergy Clin Immunol 1998; 101: 564–565. 35 Harle DG, Baldo BA. Drugs as allergens:an immunoassay for detecting IgE antibodies to cephalosporins. Int Arch Allergy Appl Immunol 1990; 92: 439–444. 36 Pham NH, Baldo BA. Betalactam drug allergens:fine structural recognition patterns of cephalosporin-reactive IgE antibodies. J Mol Recognit 1999; 9: 287–296. 37 Moreno F, Blanca M, Mayorga C, et al. Studies of the specificities of IgE antibodies found in sera from subjects with allergic reactions to penicillins. Int Arch Allergy Immunol 1995; 108: 74–81. 38 Blanca M, Torres MJ, Garcia JJ, et al. Natural evolution of skin test sensitivity in patients allergic to betalactams. J. Allergy Clin Immunol 1999; 103: 918–924. 39 De la Fuente JL, Mayorga C, Carmona MJ, et al. Identification of a group of subjects with a negative skin test and positive RAST to penicillin. J Allergy Clin Immunol 1998); 101 Suppl 1: 8136–8137. 40 Baldo BA, Haile DC. Identification of penicillin allergenic determinants that bind IgE in the sera of patients with penicillin allergy. Mol Immunol 1990; 27: 1063–1071. 41 Harle DG. Baldo BA. Identification of penicillin allergenic determinants that bind IgE antibodies in the sera of subjects with penicillin allergy. Mol Immunol 1990; 27: 1063–1071. 42 Blanca M, Mayorga C, Sanchez F, et al. Differences in serum IgE antibody activity to benzylpenicillin and amoxicillin measured by RAST in a group of penicillin allergic subjects. Allergy 1991; 46: 632–638. Citing Literature Volume54, Issues58December 1999Pages 8-12 ReferencesRelatedInformation