tbuckley/cabot-search huggingface dataset:
TMOD-34. REACTIVE ASTROCYTES POTENTIATE TUMOR AGGRESSIVENESS IN A MURINE GLIOMA RESECTION AND RECURRENCE MODEL
Authors: Onyinyechukwu Okolie, Juli Bago, Ralf Schmid, David Irvin, Ryan Bash, C. Ryan Miller, Shawn Hingtgen
Journal: Neuro-Oncology (2016)

Surgery is a mainstay of glioma care, but the dearth of preclinical models incorporating surgical debulking has left the post-operative tumor microenvironment largely unexplored. Resection induces pathologic changes in residual cancer cells; thus understanding the impact of the post-operative environment on disease recurrence or treatment failure is important. To this end, we developed an image-guided glioma resection/recurrence model in syngeneic immunocompetent mice and investigated the impact of surgery on disease pathogenesis. Genetically engineered murine glioma cells were modified to express fluorescent and bioluminescent reporters and implanted orthotopically. Intra-operative fluorescent imaging of established tumors was used to guide microsurgery. Extent of resection was confirmed by post-operative bioluminescence imaging (BLI). Recurrence was tracked by BLI and the post-operative microenvironment was characterized by histopathology and immunohistochemistry. The impact of surgical astrocyte injury on residual glioma cell growth and invasion was examined using in vitroco-culture models. Transcriptome and secretome changes induced by surgery-related astrocyte injury were examined by RNA-seq and Luminex, respectively. Fluorescence-guided resection achieved >90% tumor reduction. Recurrent tumors exhibited increased growth rates and histopathological analysis showed increased distant recurrence compared to non-resected controls. Immunohistochemical analyses revealed that peri-tumoral astrocytes underwent pronounced cytoskeletal changes, suggesting a surgery-induced phenotypic switch. In vitroassays showed reactive astrocyte injury significantly increased migration as well as proliferation of a panel of mouse and human glioma cell lines. RNA-seq revealed expansive changes in the transcriptome following astrocyte injury, while secretome analysis identified astrocyte secretion of Cxcl5 in response to injury. This study demonstrates that peri-tumoral astrocytes undergo temporal and spatial changes after surgical tumor resection, and that surgery-induced changes influence the aggressiveness of residual tumor. Gaining a better understanding of the post-surgical microenvironment will allow optimization of therapeutic strategies and facilitate the development of new approaches that ameliorate surgery-mediated effects on recurrent tumors.
An Address Delivered at the Opening of the Section of Medicine
Authors: W. Moore
Journal: BMJ (1887)

the concrete manifestations of mind.Nay, I am quite prepared, with a physician who was also a great philosopher (Lotze, Logic, chap.v), " by one general formula of ready worship, to purchase a dispensation from any further glorification" of the principle that insanity is due to disease of the bodily organism, and must be studied as such.No doubt there has been much need in the past of the frequent repetition of this fundamental truth; still "any moral sermon becomes
Pediatric Anesthesiology
Authors: Robert M. Smith
Journal: JAMA (1960)

This second edition has been anticipated for some time and more than lives up to our high expectations. It is an entirely new book in plan and content and denotes the great expansion undergone in the practice of pediatric anesthetization since 1948. The first section, devoted to evaluation of the patient, is not an exhaustive description of the preoperative examination, as the title might suggest, but a compendium of pediatric information of all sorts that might have bearing on infants and children coming to operation. Among a host of topics we find a description of the Klipple—Feil syndrome, a practical explanation of acid-base disturbances, anatomy of cardiac defects (with catheterization data), and a resume of pulmonary physiology. The second section is a clear, concise description of anesthetic agents, techniques, and equipment. Although all methods and agents are fairly evaluated, the authors appear to favor nonrebreathing and circle absorption techniques, with
Abortion for 'wrong' fetal sex: an ethical-legal dilemma
Authors: J. Elliott
Journal: JAMA (1979)

"Please doctor, we have three girls and we want to know the sex of our new baby," says the couple seeking prenatal diagnosis. "Can you help us?" The ethical dilemma facing the physician in such cases, although perhaps less pressing than some in applied human genetics, is certainly one of the most difficult to resolve in all of medicine. Because abortion is a procedure that never elicits a noncommittal response, and because many genetics counselors are pediatricians who regard the fetus as the primary patient, it is extremely difficult for the counselor not to interfere in the decisions of parents seeking fetal sex determination for the purpose of choosing the sex of their next child. In fact, the nature of the physician-patient relationship and way in which the physician presents the information learned from prenatal diagnosis (mainly amniocentesis) invariably influences the parents' decision. There is some debate, however, about the
Postmortems.
Authors: James W. Walker
Journal: JAMA (1903)

Chicago, Sept. 29, 1903. <h3>To the Editor:</h3> —Referring to your editorial of September 5, on "Compulsory Postmortems," it seems to me worth while to emphasize the fact that permission for postmortems can frequently, if not usually, be obtained if the friends are duly considered and properly approached. It would certainly be a salutory custom from the layman's point of view if it were traditional to hold postmortems on all the dead, especially if the physicians in charge were expected by custom to write their colleagues to be present. The wholesome effect that this "facing the music" has in hospital life in calling forth every known diagnostic effort, and leading to due appreciation of responsibility because of the fear of criticism at the morgue table by one's colleagues, is well known to all who have been internes. If the layman fully understood the inward significance of the phrase "Dead men tell
The Oppenheimer Institute and Its Endorsers.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
NORWAY
Journal: JAMA (1953)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Meeting Highlights: Breast Cancer, Epithelial Cells, and Extracellular Matrix
Journal: JNCI Journal of the National Cancer Institute (1984)

Meeting Highlights: Breast Cancer, Epithelial Cells, and Extracellular Matrix Get access JNCI: Journal of the National Cancer Institute, Volume 73, Issue 4, October 1984, Pages 999–1001, https://doi.org/10.1093/jnci/73.4.999 Published: 01 October 1984
Correction: Dame Sheila Sherlock
Journal: BMJ (2002)

With his outstanding academic record Donald Crowther should have been a consultant physician, possibly at his teaching hospital.Instead, he became one of the finest desk editors of the 20th century, though only by overcoming adversities-a brother's high profile career, his position in a power struggle between the fiery editor of the BMJ and the BMA, and the development in middle life of a severe depressive illness.Journalism ran through Donald's family.
An Address on the Present Relation of Insanity to the Criminal Law of England
Authors: W. Orange
Journal: BMJ (1877)

MERE depravity must be carefully distinguished from actual mental disease.The term moral insanity is, I think, better avoided in a criminal court of law.In almost all forms of insanity, as Esquirol long ago pointed out, the moral faculties become impaired, more or less; and, in some cases, the impairment of the moral faculties is disproportionately greater than that of the intellectual faculties.Moral perver- sion also is sometimes the earliest noticeable symptom of the invasion of insanity; and it is often also found, strongly marked, in some members of a family, of which other members are actually insane.In forming his diagnosis, the medioal witness must then give to moral pervsion its due weight as a symptom.But, unless connected with such moral perversion there be found other distinct evidence of mental im- pairment, it would appear to be better to speak of absence, or defect, or obliteration of the moral faculties, and not to make use of the term insanity at all.The proper mode of dealing with persons who are apparently bereft of all moral qualities forms a separate subdivision of the subject of criminal science.Moral depravity, it has been said, cares not for law ; moral insanity cares, but cannot obey; but then, even if this were admitted as a correct definition, it might still be urged that such' inability to obey arises from defect of judgment, or of will, or of self-control, and that therein consists the insanity.As the law now stands, however, the medical witness is usually not permitted to place his opinion before the court in the manner above described, but is required to answer a certain set of queries ; and thus, if the case be one of homicide, he will be ask-ed probably-i.Whether the accused knew that the act of stabbing, or shooting, or whatever it may be, would produce death; 2. Whether his state of mind was such that he did not know that it is wrong to kill ; or 3. Whether, if he be suffering from a delusion, it is a delusion of such a character that, if it were true, the act of killing would be justifiable.With regard to the first of these questions, it has already been observed that, only when raving delirium or utter dementia is present, is there real unconscious- ness of the act done.Such an instance occurred lately in the case of Robert Edwards, who, whilst an inmate of the Norwich Hospital, killed three boys, who were also inmates, by striking repeated blows on their heads with a pair of tongs in the middle of the night.That man was shortly afterwards removed to Broadmoor, and he is there still, in a state of acute insanity.It is probable that, at the time of getting out of his bed at night and killing the boys, he had no distinct or clear idea of what he was doing; but cases of this descrip-
Mucoid Pseudomonas aeruginosa
Authors: Herbert Y. Reynolds
Journal: JAMA (1976)

Two adult patients with cystic fibrosis had late onset of symptoms with principal involvement only of the lungs. The absence of other typical features of cystic fibrosis confused the diagnosis. Recovery of mucoid<i>Pseudomonas aeruginosa</i>from sputum cultures helped to establish the diagnosis in these patients, because these mucoid isolates are rarely obtained from subjects who do not have cystic fibrosis. Recent findings, which have identified the mucoid isolates as predominantly a single strain of<i>P aeruginosa</i>and have documented its widespread carriage in the United States by patients with cystic fibrosis, point to an interesting epidemiologic relationship between this bacterium and this disease. (<i>JAMA</i>236:2190-2192, 1976)
Cyberman
Authors: Roberto Llamas
Journal: Annals of Internal Medicine (1996)

Ad Libitum15 December 1996CybermanRoberto Llamas, MDRoberto Llamas, MDMiami Beach, FL 33140.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-12-199612150-00010 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Anthropologists guessthat next century willbring to humans both, thrill,and Darwinian distress.Homo cybers in glorywill return to the caveand in there try to savehis incredible story.He'll remember a flowerand the pale breast just hiddenand moonrays from the towerand the pleasure forbidden.but alas, just the turningson his loyal PCwill respond to his yearnings.To be or not to be. Author, Article, and Disclosure InformationAffiliations: Miami Beach, FL 33140.Corresponding Author: Roberto Llamas, MD, Miami Heart Institute, 4701 North Meridian Avenue, Miami Beach, FL 33140. Previousarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 December 1996Volume 125, Issue 12Page: 989 ePublished: 15 August 2000 Issue Published: 15 December 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
International Society of Nephrology Global Kidney Health Atlas: structures, organization, and services for the management of kidney failure in South Asia
Authors: Smita S. Divyaveer, Raja Ramachandran, Manisha Sahay, Dibya Singh Shah, Fazal Akhtar, Aminu K. Bello, Arpana Iyengar, David W. Johnson, David C.H. Harris, Adeera Levin, Meaghan Lunney, Muhibur Rahman, Harun-Ur Rashid, Syed Saad, Deenaz Zaidi, Mohamed A. Osman, Santosh Varughese, Eranga S. Wijewickrama, Maryam Khan, Feng Ye, Marcello Tonelli, Ikechi G. Okpechi, Vivekanand Jha
Journal: Kidney International Supplements (2021)
Yale Journal of Biology and Medicine, New Haven
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Allogeneic stem cell transplantation and minimal residual disease in patients with AML in first complete remission
Authors: Jurjen Versluis, Jan J. Cornelissen
Journal: HemaSphere (2018)

Department of Hematology, Erasmus University Medical Center Cancer Institute, Rotterdam, The Netherlands This is an open access Abstract Book distributed under the Attribution-NonCommercial-NoDerivs (CCBY-NC-ND), which allows third parties to download the abstracts and share them with others as long as they credit the author and the abstract book, but they cannot change the content in any way or use them commercially. http://creativecommons.org/licenses/by-nc-nd/4.0
THE ETIOLOGY OF PEMPHIGUS
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Patient Behavior for Blood Pressure Control
Journal: JAMA (1979)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract B41: Haptotaxis and direct remodeling of the extracellular matrix by tumor cells is important for metastasis
Authors: Madeleine J. Oudin, Oliver Jonas, Tatiana Kosciuk, Liliane Broye, Jeff Wyckoff, Joelle Klazen, John Lamar, Sreeja Asokan, Charlie Whittaker, Robert Langer, Michael Cima, Kari Wisinski, Richard Hynes, Douglas Lauffenburger, Patricia Keely, James Bear, Frank Gertler
Journal: Cancer Research (2016)

Abstract This abstract is being presented as a short talk in the scientific program. A full abstract is printed in the Proffered Abstracts section (PR15) of the Conference Proceedings. Citation Format: Madeleine J. Oudin, Oliver Jonas, Tatiana Kosciuk, Liliane Broye, Jeff Wyckoff, Joelle Klazen, John Lamar, Sreeja Asokan, Charlie Whittaker, Robert Langer, Michael Cima, Kari Wisinski, Richard Hynes, Douglas Lauffenburger, Patricia Keely, James Bear, Frank Gertler. Haptotaxis and direct remodeling of the extracellular matrix by tumor cells is important for metastasis. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Metastasis; 2015 Nov 30-Dec 3; Austin, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(7 Suppl):Abstract nr B41.
Peristapedial Elastic Fibers
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Analysis of Transfusion Dependency Development and Disease Evolution in Patients with MDS with 5q- and without Transfusion Needs at Diagnosis
Authors: Felix Lopez-Cadenas, Blanca Xicoy, Silvia Rojas P, Kaivers Jennifer, Ulrich Germing, Teresa Bernal, Juan Carlos Caballero, Carme Pedro, Marisa Calabuig, Meritxell Nomdedeu, Beatriz Arrizabalaga, Carlos Cervero, Rosa Collado, Gemma Azaceta, Maria José Requena Rodríguez, Bernardo Gonzalez, Alba Redondo, Guillermo Sanz, María Consuelo Del Cañizo, María Díez Campelo
Journal: Blood (2016)