tbuckley/cabot-search huggingface dataset:
Abstract 851: The Cardioprotective Effect Of Glycogen Synthase Kinase-3β (gsk-3β) Inhibitors Involves Inhibition Of Mitochondrial Adenine Nucleotide Transport
Authors: Samarjit Das, Elizabeth Murphy, Charles Steenbergen
Journal: Circulation (2007)

Inhibition of GSK-3β has been shown to reduce ischemia-reperfusion injury by acting on the mitochondria. We aimed to determine the mechanism by which inhibition of GSK-3β mediates cardioprotection. Rats were treated with specific GSK-3β inhibitors, SB216763 (3 μM) or SB415286 (10 μM) 15 min prior to ischemia. Both inhibitors significantly improved post-ischemic left ventricular function after 20 minutes of ischemia compared to control. Mitochondria were isolated from all three groups of hearts immediately after 15 min perfusion with/without GSK-3β inhibitors. Both the SB compounds significantly reduced state 3 respiration as well as ATP consumption during anoxia. Consumption of ATP during anoxia was measured by allowing mitochondria in an oxygraph chamber to consume oxygen until they became anoxic, and the rate of consumption of added ATP was measured at 20, 40, and 60 minutes of anoxia. GSK-3β inhibitors significantly slowed anoxic mitochondrial ATP consumption. Similarly, GSK-3β inhibitors significantly reduced ATP consumption when sodium cyanide was used to stop mitochondrial respiration and also when the mitochondria were deenergized by uncoupler addition. This reduction in ATP consumption could be due to inhibition of ATP entry into the mitochondria through Voltage dependent anion channel (VDAC) and/or the adenine nucleotide transporter (ANT), inhibition of some other unknown protein which may directly inhibit mitochondrial transport, or inhibition of the F1F0 ATPase. To identify proteins that might be involved in this reduced ATP consumption, western blot analysis with phospho-Akt substrate antibody and 1-D gel phosphorylation site analysis staining revealed the GSK-3β inhibitors significantly decrease the phosphorylation of a 32 kDa protein compared to control mitochondria. We then cut out the 32 kDa band and used mass spectrometry to identify proteins. Voltage dependent anion channel members 1, 2 and 3 were all identified along with the adenine nucleotide translocator and γ-subunit of the F1 ATPase. Taken together the data indicate that GSK-3β regulates mitochondrial energetics under anoxic conditions, which may play an important role in cardioprotection.
Incentive payments may reduce time for clinical care
Authors: M. Rickenbach
Journal: BMJ (2001)

Risk of adverse birth outcomes near landfill sitesEvidence suggests that it is probably safe for fetuses to develop near landfill sites Editor-Elliott et al report a large geographical study of adverse birth outcomes in populations living near landfill sites. 1 They conclude that there are small excess risks of congenital anomalies and low birth weight in such populations.Although they advise caution when interpreting their results, the study is nevertheless hailed by the press and by environmental groups as evidence that living near such sites is hazardous to health. 2 The concerns felt by parents, often with no opportunity to move elsewhere, are fuelled, and perhaps on no grounds.Scientists contribute to the media generated intrigue in subtle ways.For example, the description of the paper in an editorial by McNamee and Dolk as a report "on the risks to fetuses associated with residence" when "a study of the statistical association between reported anomalies and residence" would have been more accurate and less sensationalist. 3 Health authorities are left to pick up the pieces when a story breaks, with no advance warning, about a landfill site in their area.Another interpretation of the results of Elliott et al is that this essentially negative study goes some way to reassuring other scientists who have been studying this question that it is probably safe for fetuses to develop near such sites.Any scientist who has any experience of multivariate epidemiological analysis would have to admit that such small and inconsistent excesses and deficits, even though significant, could well be attributable to inadequately adjusted social deprivation, to name but one of many important confounders.The fact that there was no increase after the landfill sites became operational, and a significant deficit of anomalies around landfill sites in Scotland, must leave even the most determined author feeling uneasy about suggesting a causal association.Epidemiological techniques used in this study are blunt instruments unlikely to detect subtle or unidentified effects.Perhaps it is time for epidemiologists to admit that their tools are inadequate to answer this question.Other scientists should take this forward by developing better techniques to identify any putative agents in the gas emissions, leachates, and soil that may be of sufficiently high concentrations to affect human health.Many of these landfill sites are unattractive and foul smelling, attracting seagulls and peppering the landscape with rubbish.More imaginative long term wastemanagement solutions are long overdue.
Recommendations Regarding the Use of Vaccines That Contain Thimerosal as a Preservative
Journal: JAMA (1999)

On October 20, 1999, the Advisory Committee on Immunization Practices (ACIP) reviewed information about thimerosal in vaccines and received updates from CDC's National Immunization Program and several vaccine manufacturers on the current and anticipated availability of vaccines that do not contain thimerosal as a preservative. The review was prompted by a joint statement about thimerosal issued July 8, 1999, by the American Academy of Pediatrics (AAP) and the Public Health Service (PHS) (1) and a comparable statement released by the American Academy of Family Physicians (2). These statements followed a Congressionally mandated Food and Drug Administration (FDA) review of mercury in drugs and food, which included a reassessment of the use of thimerosal in vaccines.
Benign imitator
Authors: E. C. Levister
Journal: JAMA (1978)

SPHENOID sinus mucocele is a rare entity; there have been less than 100 cases reported in the English literature up to 1975 since the initial description by the Swedish surgeon John Berg in 1889. It is an expanding lesion with compression of the internal carotid artery, cavernous sinus, pituitary gland, and the first six cranial nerves. We report this case to alert physicians to this impressive but benign disorder so that appropriate roentgenograms will be obtained and early otorhinolaryngologic referral made. <h3>Report of a Case</h3> A 35-year-old woman had a three-week history of diplopia, many years of nasal obstruction, a constant diffuse midline facial ache, and a four-week sensation of "something in my left eye." Her nasal septum was very irregular, with obstruction and bilaterial polyps. There was a left proptosis and paralysis of the lateral rectus muscle. The disks were normal. The visual acuity in the left eye was
L'infection bacillaire et la tuberculose che[ill] l'homme et chez les animaux.
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
"HUMANE" MURDER.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Evaluation of the buffy-coat smear for rapid detection of bacteremia
Authors: H. Reik
Journal: JAMA (1981)

Buffy-coat smears prepared from 599 blood samples, obtained simultaneously with blood for culture, were examined for bacteria. Each blood sample was quantitatively cultured on chocolate agar. Twenty-one blood cultures (3.6%) from 17 patients were positive. Two (11.7%) of the 17 patients had positive buffy-coat smears. One patient had two positive smears, for a total of three positive buffy-coat smears from 21 positive blood cultures. Chart reviews were performed for two patients with positive buffy-coat smears, three patients with positive blood cultures (containing the same organisms as the two study patients) but negative buffy-coat smears, and six additional patients who had had positive buffy-coat smears between 1974 and 1979. Of the eight patients with positive smears, six (75%) were infected with Gram-positive cocci, three of which were<i>Streptococcus pneumoniae</i>. Mortality was 100%. (<i>JAMA</i>1981;245:357-359)
Current evidence does not support a role for vertebroplasty
Journal: BMJ (2011)

Rachelle Buchbinder and Paul Glasziou, wish to clarify two points that we inadvertently altered during editing.Firstly, in relation to the first sentence, they say that, although they agree with D J Wilson (reference 1) that vertebroplasty cannot be recommended as first line therapy, current evidence favours no role whatsoever (this should have been be reflected in the title too).Secondly, they say that rather than suggesting that doubts remain about the role of vertebroplasty for osteoporotic vertebral fracture (as stated in the final paragraph), they had wanted to make the point that if others thought additional randomised trials were justified, it would be essential to blind treatment allocation, participants, and investigators, necessitating the use of a sham or placebo control.
Cervical spondylosis--a genetic factor.
Journal: BMJ (1969)

Joints and their DiseasesPain in one or more joints is a common complaint in general practice, and advances in diagnosis and treatment have been rapid in this field.This week we start publication in the Current Practice section of a short series of articles on joints and their diseases.The introductory article will be followed by accounts of the individual joints, reviewing the common disorders which affect them, methods of examination, and simple therapeutic procedures.Many patients with pain in or around a joint-such as tennis elbow-can have the condition diagnosed and treated in the general practitioner's surgery.This saves time for the patient and gives the doctor satisfaction.We hope the series will encourage more doctors to develop an interest in this field.
Enteritis Necroticans
Authors: C. D. Calnan
Journal: BMJ (1950)

MEDICAL MEMORANDA BRICTISH culture.Smears from the gums showed fusiform organisms and Treponema vincenti.Sputum yielded a moderate growth of Str.haemnolyticus.The w.b.c.numbered 14,000, of which 78%/.were polymorphs.Treactment.-The patient received 100,000 units of penicillin intramuscularly four-hourly for 13 days.Tablets of sulphamezathine, 1 g.four-hourly, were also given for eight days.The eyes were cleaned with saline, and eye-drops of sulphacetamide sod.um (100') instilled hourly.Zinc and castor-oil cream
THE HEALTH OF SANTIAGO DE CUBA.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Gynecologic Operations.
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Paroxysmal nocturnal hemoglobinuria: Analysis of the effects of mutantPIG-A on gene expression
Authors: N Kanai, T M Vreeke, C J Parker
Journal: American Journal of Hematology (1999)

Compelling evidence indicates that mutations in PIG-A are necessary for the development of paroxysmal nocturnal hemaglobinuria (PNH), however, it is unclear why mutant PIG-A stem cells have a selective advantage. Further, multiple, discrete PIG-A mutations have been detected in the peripheral blood and bone marrow of patients with PNH, but the contribution of the different mutant clones to hematopoiesis is variable. This observation implies that factors in addition to mutant PIG-A influence the proliferative properties of the abnormal cells. To investigate the etiology of the selective advantage and the clonal dominance in PNH, gene expression in cells with mutant PIG-A was analyzed. Representational difference analysis was used to compare the pattern of cDNA expression between a human lymphoblastoid cell line with mutant PIG-A and its wild-type counterpart. These experiments demonstrated that the pattern of gene expression was different between the two cells lines in that the PIG-A mutant cells failed to express antiquitin mRNA. Transfection of the mutant cells with normal PIG-A restored expression of glycosyl phosphatidylinositol anchored proteins but not antiquitin. These experiments demonstrate that differences in the pattern of gene expression can occur independent of the PIG-A mutation. Depending upon the functional properties of the involved genes, these differences could influence the proliferative properties of PIG-A mutant cells and contribute to the selective advantage and clonal dominance that characterize PNH.
Ophthalmologica, Basel
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AIDS-prompted behavior changes reported
Authors: D. E. Riesenberg
Journal: JAMA (1986)

Public awareness of the acquired immunodeficiency syndrome (AIDS) has been growing rapidly since 1982. Many authorities have expressed the hope that increased knowledge will lead to a modification of such apparent high-risk behavior as sexual promiscuity among some homosexual men (<i>JAMA</i>1985; 253:3440-3441). Data now suggest that such changes may be under way, at least in certain areas. Answers to a San Francisco questionnaire, obtained in November 1983, indicate that nonmonogamous homosexual men decreased apparently high-risk sexual practices (unprotected anal intercourse, oral-genital contact) during the preceding year (<i>Am J Public Health</i>1985; 75:493-496). Many of the subjects were enlisted from among San Francisco bathhouse patrons. Bathhouses in New York City were the subject of a recent controversy. There, a few weeks ago, the city health commissioner resigned, reportedly after a disagreement with the state health commissioner. The health commissioner who resigned is said to have taken the position that a
Three Rare Abdominal Tumors Reported by Proctologist
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE QUEST OF POTENTIAL ENERGY
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tacrine for Alzheimer's Disease
Authors: Wijdan A. Luqman
Journal: JAMA (1994)

<h3>To the Editor.</h3> —I disagree with the statement in the article on tacrine by Dr Knapp and colleagues<sup>1</sup>that there was no evidence that the large number of patient withdrawals biased the overall conclusions of their study. The number of patient withdrawals was progressively higher for the higher doses (ie, 36% for group 1 [placebo], 53% for group 2, 68% for group 3, and 73% for group 4). These were very high rates. However, they did correspond with the higher doses and supported the dose-related toxicity. Table 2 of their article suggested that duration of therapy was also a factor. To me, their data suggested an important contribution from patient withdrawal. The variances for the indexes recorded in their Table 1 suggested significant variability and/or skewedness. But the most concerning observation is related to the changes in duration of Alzheimer's disease at the initiation of the study and at