tbuckley/cabot-search huggingface dataset:
Stem Cell Transplantation Can Provide Durable Disease Control in Blastic Plasmacytoid Dendritic Cell Neoplasia (BPDC): A Retrospective Study From the European Group for Blood and Marrow Transplantation (EBMT)
Authors: Sascha Dietrich, Damien Roos-Weil, Ariane Boumendil, Emanuelle Polge, Jian-Jian Luan, Dominique Bron, Enric Carreras, Arturo Iriondo Atienza, William Arcese, Dietrich Beelen, Jan J Cornelissen, Nicolaus Kröger, Giuseppe Milone, Giuseppe Rossi, Herve Tilly, Jean Paul Vernant, Vanderson Rocha, Anna Sureda, Mohamad Mohty, Peter Dreger
Journal: Blood (2011)
PHYSICIANS SPECIALIZING IN PATHOLOGY AND CLINICAL PATHOLOGY
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Filing Complaints Against Residency Programs: Part I
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Immune-neuro-endocrine interactions: facts and hypotheses
Authors: H. O. Besedovsky
Journal: Endocrine Reviews (1996)

I. Introduction THE existence of mechanisms that provide immunity to an infective agent was inferred from empirical observations obtained through the ingenuity and deductive capacity of early investigators. The first procedures for vaccinations and serotherapy resulted from these observations. The implementation of these procedures, probably the most important contribution of immunology to medical science, was, at first, based on a very rudimentary knowledge of the immune system. During the first half of the 20th century, this rather primitive knowledge coincided with evidence showing that the endocrine and nervous systems integrate and regulate different bodily functions. Therefore, based on some supportive data, it was considered that immune mechanisms may also be influenced by these systems. However, at the beginning of the second half of the 20th century, most efforts were directed at understanding the molecular and cellular basis of the immune response and the mechanisms of acquisition of immunological diversity and self-tolerance.
Bedside teaching.
Journal: BMJ (1968)

Description of immunofluorescent antibody techniques for rapid diagnosis of respiratory syncytial virus infection (p.602) evaluation of techniques for cultivating viruses in the " common cold " syndrome (p.606).Necrotic Cervicitis: Virus of herpes simplex incriminated as the causative organism in six zases of severe necrotic cervicitis (p.610).Missing Loop: An incidence of 8.7 dislocations
Authors' reply
Authors: G. Pountain, M. Keogan, D. Brown, B. Hazleman
Journal: Annals of the Rheumatic Diseases (1994)

Matters arising al7 did not show the results of their assay in patients with other rheumatic diseases.However, the fact that 2/5 of their control sera were also positive indicates that their assay is not specific.Finally, since ANA are found in a very large proportion of pauciarticular onset JCA patients (88% in our study), we do not think that the presence of anti-RA 33 antibodies in this particular subset of patients could add any useful in- formation.In addition, anti-RA 33 antibody assay is clearly longer to perform and less widely available than ANA test.In conclusion, we think that there is not enough evidence to support a wider use of APF and anti-RA 33 antibody assay in JCA.
Detection of hepatic neoplasm. Hepatic scanning combined with liver-function studies
Authors: F. E. Wilson
Journal: JAMA (1969)

In 69 patients, hepatic scans with gold Au 198 and determinations of serum alkaline phosphatase (SAP) levels were 78% accurate (in 14 of 18 patients) and 80% accurate (in 12 of 15), respectively, in detecting hepatic neoplasm and 93% accurate (in 14 of 15) when used together. When results of both studies were normal, hepatic neoplasm was present in 4% (one of 23 patients). The likelihood of hepatic neoplasm in the presence of a positive scan and elevated SAP level was 92% (in 11 of 12). No liver-function studies were helpful in eliminating the problem of false-negative scans. The presence of multiple space-occupying lesions without associated increased extrahepatic uptake was effective in differentiating hepatic neoplasm from cirrhosis. In 11 patients with lymphoma, increased splenic uptake of gold Au 198 occurred in seven. In some instances, this may have been related to hepatic involvement with lymphoma, and, in others, to increased phagocytic activity of the reticuloendothelial system of the spleen with or without splenomegaly.
Renal Scanning
Authors: Alexander Gottschalk
Journal: JAMA (1967)

In spite of extensive efforts by several investigators in the late 1950's to perfect "in transit" scanning of continuously excreted contrast agents labeled with radioactive iodine (<sup>131</sup>I), renal scanning did not become a popular procedure until the introduction of chlormerodrin Hg 203. With this material, approximately 60% of the injected dose is in the kidneys within one to two hours. Although the agent is eventually excreted so that only about 10% ultimately remains fixed in the renal parenchyma, the excretion is slow. As a result, at one hour, renal scanning can be done with assurance that the renal isotope concentration will remain reasonably constant throughout the scan. Since all the renal scanning agents currently in use localize in the renal parenchyma (principally in the cortex), the scan has been used to (1) identify the degree of parenchymal function—often possible when the kidneys are not visualized on intravenous pyelograms; (2)
A randomized, double-blind, placebo-controlled phase III study of ramucirumab versus placebo as second-line treatment in patients with hepatocellular carcinoma and elevated baseline alpha-fetoprotein following first-line sorafenib (REACH-2).
Authors: Andrew X. Zhu, Peter R. Galle, Masatoshi Kudo, Richard S. Finn, Ling Yang, Paolo Abada, Josep M. Llovet
Journal: Journal of Clinical Oncology (2016)

TPS4145 Background: Ramucirumab (Ram) is a human IgG1 monoclonal antibody that inhibits ligand activation of the vascular endothelial growth factor receptor 2. The Phase III REACH study assessed Ram in the treatment of patients with advanced hepatocellular carcinoma (HCC) after prior sorafenib. Ram was well-tolerated. A significant improvement in overall survival (OS) in the overall population (N = 565) was not demonstrated (HR = 0.87; p = 0.14). However, a meaningful improvement in OS was observed in a prespecified subgroup of patients with baseline alpha-fetoprotein (AFP) ≥ 400 ng/mL (N = 250) (HR = 0.67, p = 0.006; median OS Ram 7.8 months vs. placebo 4.2 months). Methods: Designed to confirm the treatment effects of Ram in patients with elevated AFP, REACH-2 is a randomized, double-blind, placebo-controlled, global Phase III study of Ram and best supportive care (BSC) versus placebo and BSC in patients with HCC and elevated baseline AFP following prior therapy with sorafenib; Child-Pugh score < 7; Barcelona Clinic Liver Cancer Stage C or Stage B disease not amenable/refractory to locoregional therapy; AFP ≥ 400 ng/mL; and ECOG performance status 0‒1. Patients with a history of hepatic encephalopathy, clinically meaningful ascites, liver transplant, or hepatic locoregional therapy after sorafenib are not eligible. Eligible patients will be randomized 2:1 to receive Ram (8 mg/kg) or placebo as an intravenous infusion on day 1 of each 14-day cycle until radiographic or clinical disease progression or criterion for discontinuation are met. The primary objective is to assess the OS for patients treated with Ram versus placebo, and assumes an OS HR of 0.7 (85% power; 2-sided type I error 0.05). Target enrollment is 399 patients with a final analysis at 318 events (20% censoring). Secondary objectives include progression-free survival, objective response rate, safety, and patient-focused outcomes. Other objectives are assessments of biomarkers relevant to angiogenesis and HCC. Clinical trial information: NCT02435433.
Children Are Like That.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Trends in Health in the United States
Authors: Manning Feinleib, Ronald W. Wilson
Journal: Environmental Health Perspectives (1985)

The National Center for Health Statistics (NCHS) conducts a variety of surveys designed to provide cross-sectional estimates of the prevalence of various factors measuring the health of Americans. When these cross-sectional estimates are put together and plotted over time, they provide a picture of the trends in the health of the population. However, differences in methodology, completeness of coverage, validity and reliability of the information, and changing attitudes about health and illness influence these trend patterns and sometimes make them difficult to interpret. Six different measures of the health of Americans discussed include trends in life expectancy, which is related to the total mortality rate; trends in mortality by specific causes; trends in morbidity or the prevalence of various illnesses, including both acute and chronic conditions; trends in the estimates of various types of disabilities and impairments in the population; trends in expenditures for medical care and services; and finally, some assessments of trends in several risk factors and physiological characteristics obtained by direct measurements of individuals.
Diseases of the Skin.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Comparison of Prednisolone with Aspirin or other Analgesics in the Treatment of Rheumatoid Arthritis: M. R. C. Report
Authors: W Copeman, Charles Dodds, J Duthie, H West, Mr Sanderson, ) Participating, A Hill, J Kellgren, G Kersley, R Mason, W Martin
Journal: Annals of the Rheumatic Diseases (1959)

The results of previous trials conducted by the Joint Committee (1954, 1955, 1957a) showed that there was little to choose between cortisone and aspirin in the long-term management of patients with rheumatoid arthritis, and a similar result was obtained in a trial conducted by the Empire Rheu- matism Council (1955, 1957).Since the time of these trials many analogues of cortisone have been introduced, and, of these, prednisone and pred- nisolone appeared to be particularly suitable for the treatment of rheumatic diseases.Further trials were therefore initiated by the Joint Committee in 1955.In the first of these prednisone was compared with cortisone in the long-term treatment of rheumatoid arthritis.The results of this trial, which have already been published (1957b), showed
Nonimmunoglobulin (non-Ig)/BCL6gene fusion in diffuse large B-cell lymphoma results in worse prognosis than Ig/BCL6
Authors: Takashi Akasaka, Chiyoko Ueda, Masayuki Kurata, Hiroshi Akasaka, Hirohiko Yamabe, Takashi Uchiyama, Hitoshi Ohno
Journal: Blood (2000)
Megavitamin Therapy
Authors: Linus Pauling
Journal: JAMA (1976)

<h3>To the Editor.—</h3> In my letter there is the statement "that an increased intake of ascorbic acid can reinforce the natural protective mechanisms of the body in a significant way, such as to control various diseases to some extent," and that "my analysis of the evidence about ascorbic acid and the common cold was submitted to<i>JAMA</i>in March 1975, and, accordingly, may be available to readers before long." The article was, in fact, not accepted for publication by<i>JAMA</i>. Readers who are interested in seeing it will find it published in full in the<i>Medical Tribune</i>, in two installments, the first part appearing in the March 24, 1976, issue.
Book Review Oral Pathology: A histological, roentgenological, and clinical study of the diseases of the teeth, jaws, and mouth . By Kurt H. Thoma, D.M.D., and Charles A. Brackett, D.M.D. 4°, cloth, 1306 pp., with 1370 illustrations, including 137 in color. St. Louis: The C. V. Mosby Company, 1941. $15.00.
Journal: New England Journal of Medicine (1942)
DEMENTIA PRÆCOX.
Authors: F. X. DERCUM
Journal: JAMA (1905)

In the writings of some of the earlier authors, notably Pinel, Spurzheim and Esquirol, we find that they recognized the affection now so widely known as dementia præcox. This recognition was, to be sure, vague and imperfect; the affection was naturally confounded with other dementias, paretic, organic and alcoholic and yet these early writers were aware that there was a form of idiocy which was not congenital, and which supervened only after the organism had attained a certain degree of development. Spurzheim, for instance, speaks of an "accidental idiocy," while Esquirol speaks of "accidental and acquired" idiocy; thus the latter says that there are children who are very well at birth, who increase in stature at the same time that their intelligence develops and who are very sensitive, lively, irritable, passionate and possessed of a brilliant imagination, a developed intelligence and an active spirit. This activity, not being in
Jitterbug
Authors: Leslie G Cohen
Journal: Annals of Internal Medicine (2013)

On Being a Doctor18 June 2013JitterbugLeslie G. Cohen, MDLeslie G. Cohen, MDFrom Waltham, Massachusetts.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-158-12-201306180-00013 Audio Reading - “Jitterbug” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Jitterbug," by Leslie G. Cohen. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The rhythmic beat of once-familiar swing music jogged my memory. Was it “One O’Clock Jump” or “Cottontail”? I know I'd heard it before, many times long ago. The radio station seldom played music of the old swing bands.As a teenager, I had worked summers on Atlantic City's boardwalk and went every weekend to the Steel Pier's Marine Ballroom to hear the great bands—Woody Herman, Artie Shaw, Benny Goodman, Tommy and Jimmy Dorsey, and all the others. Did I hear it there?Suddenly, I remembered a patient, Gladys Spink, and smiled. Gladys Spink! It all came back. I hadn't seen ... Author, Article, and Disclosure InformationAffiliations: From Waltham, Massachusetts.Corresponding Author: Leslie G. Cohen, MD, 501 Lexington Street, Unit 73, Waltham, MA 02452; e-mail, [email protected]com. PreviousarticleNextarticle Advertisement Audio Reading - “Jitterbug” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Jitterbug," by Leslie G. Cohen. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 18 June 2013Volume 158, Issue 12Page: 919KeywordsAdolescentsArmed forcesChartsDietElderlyHematologic testsMemory ePublished: 18 June 2013 Issue Published: 18 June 2013 Copyright & PermissionsCopyright © 2013 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Tubeless hypotonic duodenography
Authors: H. M. Goldstein
Journal: JAMA (1969)

A tubeless modification of the standard approach to hypotonic duodenography has produced successful examinations in more than 85% of studies. Patient discomfort and inconvenience inherent in tube manipulation is alleviated. Procedure time is significantly reduced and the examination may be performed immediately following a conventional upper-gastrointestinal tract examination if desired. Most important, tubeless hypotonic duodenography is a simple, convenient, and feasible examination accessible to all radiologists for evaluating duodenal and pancreatic disease.
Editors' Introduction:<i>Annals</i>Supplement From the Robert Wood Johnson Foundation Clinical Scholars Program
Journal: Annals of Internal Medicine (2014)

Supplement18 November 2014Editors' Introduction: Annals Supplement From the Robert Wood Johnson Foundation Clinical Scholars ProgramFREEThe EditorsThe EditorsSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M14-2407 SectionsAboutVisual AbstractPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Since its inception in 1972, the Robert Wood Johnson Foundation (RWJF) Clinical Scholars Program has contributed enormously to our understanding of quality and high-value health care. This electronic supplement highlights work by current and former Clinical Scholars that describes low-cost system-level or community-partnered health care innovations that hold promise to improve quality of care. This is a particularly appropriate time to celebrate the work of the program because the RWJF will be concluding it in 2017 as the foundation's priorities shift to supporting the development of leaders for the transformation to a Culture of Health (www.rwjf.org/en/about-rwjf/from-the-president.html).The Annals supplement articles address such topics as information technology approaches and financial incentives designed to improve care delivery in primary settings, a community-partnered intervention to improve treatment of depression, an antibiotic self-stewardship program, patient satisfaction with nurse coordinators, a description of a tool to measure hospital-wide performance on 30-day readmissions, and a framework for measuring quality that focuses on patients with multiple chronic conditions. A common thread running through this material is the pursuit of health care value through evaluation of practical interventions for common clinical problems.Dr. Carol Mangione, co-director of the RWJF Clinical Scholars Program at the University of California, Los Angeles, along with Jaya Rao and Christine Laine (Annals Deputy Editor and Editor-in-Chief, respectively), served as editors for this supplement.—The Editors Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationAffiliations: Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics 18 November 2014Volume 161, Issue 10_SupplementPage: S1KeywordsAntibioticsHealth careHealth care qualityInformation technologyMotivationNursesPrevention, policy, and public healthRunning ePublished: 18 November 2014 Issue Published: 18 November 2014 CopyrightCopyright © 2014 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...