tbuckley/cabot-search huggingface dataset:
GERMINAL CENTER CELLS AND THE IMMUNE MECHANISM
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Intradermal Immunization With Rabies Vaccine
Authors: Nizar Ajjan
Journal: JAMA (1980)

We report a comparative study of the Mérieux Institute's inactivated rabies vaccine administered intradermally or subcutaneously. Vaccine safety was satisfactory, with only minor local and generalized reactions. Serological effectiveness was outstanding: all of those who had been seronegative became seropositive following either two intradermal or subcutaneous injections given one month apart. A comparison of the intradermal and subcutaneous routes demonstrated several important points. Antibody titers developing after subcutaneous immunization were greater than after intradermal immunization. The kinetics of antibody development during primary immunization were parallel in the two immunization protocols. Eleven months after primary immunization, subcutaneous administration of a booster dose of vaccine resulted in a titer elevation 1.86-fold greater than that in intradermal administration. Each of these levels indicated good serological response. (<i>JAMA</i>1980;244:2528-2531)
Special Communication
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hyperhomocyst(e)inemia Is a Risk Factor for Arterial Endothelial Dysfunction in Humans
Authors: K. S. Woo, J. E. Sanderson, Y. Y. Sun, P. Chook, A. S. P. Cheung, L. T. Chan, C. Metreweli, Y. I. Lolin, D. S. Celermajer
Journal: Circulation (2000)
Reply
Authors: Hans-Marc J. Siebelink, Paul K. Blanksma, Harry J.G.M. Crijns, Jeroen J. Bax, Ad J. van Boven, Tsjerk Kingma, D.Albertus Piers, Jan Pruim, Piet L. Jager, Willem Vaalburg, Ernst E. van der Wall
Journal: Journal of the American College of Cardiology (2001)
Oncology
Authors: J. E. Karp
Journal: JAMA (1991)

The progress in molecular technology that occurred in the 1980s is being translated in the 1990s to the bedside. Physicians will begin applying principles of molecular biology to the care of patients with cancer to an ever-increasing extent as the decade progresses. This promises to be one of the most exciting eras in which one practices medicine. Perhaps A. erhaps the most dramatic example is the evolution of gene therapy in human disease. In brief, active genes capable of expressing their encoded proteins are introduced into cells, eg, by using an inert retrovirus to insert the gene into the host cell's DNA. The gene-directed biochemical alterations can then instruct the cell to undertake a function that it otherwise could not optimally perform. A recent study<sup>1</sup>of tumor suppressor gene transfection in cultured human colon cancer cells provides a glimpse of how gene therapy could theoretically alter the malignant phenotype
Another reason to combat infections in cystic fibrosis
Authors: P. Gunby
Journal: JAMA (1982)

Recurrent infections or other environmental-internal factors, rather than abnormal development, appear to be involved in the tracheobronchial gland hypertrophy and hypersecretion noted in older cystic fibrosis patients. That is the conclusion of researchers at Toronto's Hospital for Sick Children, who say that "this observation emphasizes the importance of aggressive prophylactic therapy to prevent and eradicate infection in the long-term care" of these patients, many of whom now are surviving into adulthood. Jennifer M. Sturgess, PhD, and John Imrie, BSc, examined autopsy specimens from 25 infants who did not have cystic fibrosis and from 22 infants with the disease and either no history of meconium ileus or meconium ileus with or without evidence of lung infection. The tracheal submucosal gland development pattern was similar in infants both with and without cystic fibrosis. However, the infants with cystic fibrosis had increased dilatation of the gland lumens. The investigators hypothesized, but were unable
Heroin Maintenance
Authors: Max Fink
Journal: JAMA (1972)

<h3>To the Editor.—</h3> In the EDITORIAL "Comments on 'Heroin Maintenance' " Vincent Dole, exercised restraint in criticizing the pharmacological issues involved (220:1493, 1972). We have studied and used intravenously administered heroin since 1967. Even in laboratory settings, with measured quantities and controlled rates of administration, we have observed difficult, untoward reactions. The most severe have been clinical grand mal convulsions (on three occasions) and electrographic seizures (induced regularly in almost all postwithdrawal addicts). We have also observed transient tachycardia and irregular cardiac rhythms, bradypnea, and stuporous states.<sup>1</sup> If we lacked a long-acting opiate, we would be seeking such an agent for the maintenance programs recommended by Dr. Dole. (This is the focus of the efforts now being expended in the narcotic antagonists, the principal alternative to methadone maintenance.) The drive for heroin maintenance is founded on poor pharmacology, and is a regressive step in the treatment of opiate dependence. It
P04.41 Expression and prognostic value of the transcription factors EGR1 and EGR3 in gliomas
Authors: A M Knudsen, I Eilertsen, S Kielland, M W Pedersen, M D Sørensen, R H Dahlrot, H B Boldt, C S Mellegaard, S Munthe, F R Poulsen, B W Kristensen
Journal: Neuro-Oncology (2018)

Gliomas are the most frequent primary brain tumors. For the most malignant glioma - the glioblastoma - the median survival is only 15 months. Few prognostic biomarkers are useful in daily practice, and new markers are urgently needed. EGR1 and EGR3 are transcription factors involved in the regulation of mitogenesis, cell differentiation, and EGR3 has also been suggested to be involved in cell migration. Both proteins have shown prognostic potential in other cancers. The aim of this study was to investigate the expression of EGR1 and EGR3, and investigate their prognostic value in gliomas. A total of 207 gliomas including 190 glioblastomas were stained with antibodies against EGR1 and EGR3 and assessed with a software-based classifier and semi-quantitative scoring system. A cohort consisting of tissue from 21 gliomas with high expression of mutated P53 in the tumor cells was established. For all cases, tissue with central tumor region, infiltrating tumor region and peripheral region was available. The cohort was used to investigate and quantitate protein expression in migrating tumor cells by double immunofluorescence with mutated P53 and EGR1/EGR3 respectively. In silico data analysis was performed using the Ivy GAP database. Kaplan-Meier estimates and Log-rank tests were used for survival comparison. Cox-regression was performed to identify independent variables. Both EGR1 and EGR3 protein expression was found in all investigated tumors but with considerable inter-tumor variation. EGR1 expression was declining from the central tumor area towards the tumor periphery which had the lowest expression - consistent with Ivy GAP mRNA data. EGR3 mRNA data showed that EGR3 expression increased in peripheral areas, and EGR3 immunofluorescence stainings are currently in progress to validate these findings. In univariate survival analysis, high EGR1 levels, as well as the combination of high EGR1 levels and simultaneous low EGR3 levels, were associated with improved survival in glioblastomas, but the results were non-significant when adjusted for relevant confounders. EGR1 and EGR3 expression was found in all investigated gliomas but with considerable inter- and intra-tumor variation. EGR1/EGR3 expression did not have independent prognostic potential.
Periodicity and Hypsarrhythmia in the EEG
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
8-Hydroxydeoxyguanosine in Human Leukocyte DNA and Daily Health Practice Factors: Effects of Individual Alcohol Sensitivity
Authors: Madoka Nakajima, Toru Takeuchi, Tatsuya Takeshita, Kanehisa Morimoto
Journal: Environmental Health Perspectives (1996)

A typical oxidative DNA damage, 8-hydroxydeoxyguanosine (8-OHdG), was evaluated in human polymorphonuclear leukocytes (PMN) and mononuclear leukocytes (MN) by an anaerobic determination method. The mean 8-OHdG values were the lowest level ever reported [PMN, 3.07 +/- 1.45; MN, 2.37 +/- 1.21 8-OHdG/10(6) deoxyguanosine molecules (dG); n = 92]. According to a self-administered questionnaire to 92 healthy male workers, the relationship was investigated between 8-OHdG in leukocytes and daily health practice factors, that is, the frequency of physical exercise, smoking status, alcohol drinking, nutritional balance, and the degree of mental stress. A significant difference was observed only in alcohol drinking in subjects classified by aldehyde-dehydrogenase 2 isozyme (ALDH2) genotype. Habitual alcohol intake appeared to increase 8-OHdG in PMN from ALDH2-deficient subjects. Neither age, body mass index, nor any other factors examined showed any significant correlation with the 8-OHdG levels in leukocytes.
Lung cancer: what's new in diagnosis and therapies?
Authors: Arl Medford, S Agrawal, C Free
Journal: Thorax (2009)

approximately 10/month in 1997 to 3/month in 2006 (fig 1).Progressively more CT scans were performed prior to bronchoscopy in the whole group (1994, ,20%; 2007, .60%)and in the subset of patients with a final diagnosis of cancer (1994, ,10%; 2007, .80%); the 50% breakpoint occurred in 2004.PNBs rose from ,15/year in 1994 to .55/year in 2002, with a plateau thereafter.The majority of patients had a CT scan prior to PNB, the lowest proportion (85%) in 1995.Data quality assessment revealed that 88% of the CT scan reports on the radiology department database had been transferred to the Unisoft database and 95% of the PNBs from the consultants log had been transferred.These data show clear trends in the timing and use of investigative techniques and significant loss of training opportunities.
Orbital Tumors: Results Following the Transcranial Operative Attack
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effects of Treatment on Morbidity in Hypertension
Journal: Circulation (1972)

Additional data are presented from the Veterans Administration Cooperative Study with respect to the 194 control and 186 treated male patients with initial diastolic blood pressures averaging 90-114 mm Hg. Attack rates and effectiveness of treatment were examined with respect to the following risk factors present at entry: (1) cardiovascular-renal (CVR) abnormalities, the prevalence of which was higher than in the general population of hypertensive patients; (2) diastolic blood pressure; and (3) age. Both attack rates and effectiveness of treatment increased directly with the number of these risk factors present at entry. Age and presence of CVR abnormalities at entry appeared to strongly influence subsequent attack rates, whereas entry level of blood pressure had a relatively smaller effect on attack rates. On the other hand, "effectiveness of treatment" appeared to be most influenced by the initial level of blood pressure. Patients with prerandomization diastolic blood pressure in the range of 90 to 104 mm Hg derived relatively little benefit from treatment unless they had CVR abnormalities at entry or were over 50 years of age. A longer period of follow-up would be needed to assess the value of treatment in the lower risk subgroups. With respect to side effects, the incidence of mild hypokalemia, hyperuricemia, and elevated fasting blood sugar was significantly higher in the treated group. These and other side effects should be weighed against the benefit to be expected from treating hypertensive patients at low risk.
Rheumatoid Carditis
Authors: Sheldon Schwartz
Journal: JAMA (1967)

Cardiac lesions do occur in rheumatoid arthritis and are noted more frequently at necropsy than on clinical examination and study. There is evidence that a specific form of heart disease may be present. The rheumatoid granuloma, which histologically is similar to the subcutaneous nodule, may be found in any portion of the heart. At necropsy, nonspecific changes consisting of focal infiltrations may also be found. While seldom noted clinically, pericarditis also is frequently noted at necropsy.
Trends in Ischemic Heart Disease Mortality—United States, 1980-1988
Journal: JAMA (1992)

In 1989, approximately 500,000 persons died from ischemic heart disease (IHD), the leading cause of death in the United States (1). This report summarizes an analysis by CDC to characterize trends in IHD mortality in the United States from 1980 through 1988 (the latest year for which data are available), and emphasizes comparisons by race and sex, region, and state.
Do patients who proceed immediately to coronary intervention following diagnostic catheterization have higher complication rates? Sameer Mehta, Andres Hidalgo, April W. Simon, Lynn G. Tarkington, Salvatore Battaglia, Steven D. Culler, Edmund R. Becker. Cedars Medical Center, Miami, FL, Emory University Rollins School of Public Health, Atlanta, GA
Journal: Journal of the American College of Cardiology (2001)
An Overview of Prechronic and Chronic Toxicity/Carcinogenicity Experimental Study Designs and Criteria Used by the National Toxicology Program
Authors: R. S. Chhabra, J. E. Huff, B. S. Schwetz, J. Selkirk
Journal: Environmental Health Perspectives (1990)

Since the establishment of the National Toxicology Program (NTP), there have been gradual changes in strategies to evaluate the overall toxicity of chemicals as well as their carcinogenic potential. The spectrum of toxicologic information sought on selected chemicals has been broadened by the multidisciplinary approach to evaluating chemicals. This paper describes the scientific rationale and experimental processes used by NTP in designing studies. Also, an outline of current NTP protocols are given for prechronic and chronic toxicity/carcinogenicity studies.
Only CT finds some ovarian cancer spread
Authors: J. Henahan
Journal: JAMA (1983)

In the largest study of its kind carried out so far, computed tomography (CT) has proved more accurate in measuring the extent of ovarian carcinoma than conventional clinical examination. It can also in some cases prevent the need for more than one laparatomy, according to George R. P. Blackledge, BChir, MB, MRCP, and associates at Christie Hospital, Manchester, England. Among 75 women with ovarian carcinoma, CT scans revealed undetected disease in the uteri of 13 and on the pelvic side walls of 25, Blackledge told the recent annual meeting of the British Association for Cancer Research in York, England. In only four patients did clinical examination turn up disease not visualized by CT, he said. Further, the scanning revealed 72 abdominal tumors undetected by clinical examination, hematologic studies, ultrasound, routine liver biopsy, and other tests. Also, CT consistently identified previously undetectable retroperitoneal lymphadenopathy, hepatic metastases, and small amounts of ascites.
Correction
Journal: BMJ (1959)

as the standard individual dose in combination with streptomycin as it is with isoniazid.I do not wish particularly to advocate the use of P.A.S. in any combination, for it has been shown to be less good than regimes including isoniazid and should rate as second-best treatment.I wish only to draw attention to the facts, for, as is well known in the North, " facts are chiels that winna ding."-Iam, etc.,
Young people who sleep badly.
Journal: BMJ (1978)

is more free to decide that these extraordinary procedures for prolonging life do not confer a good enough quality of life to make them suitable for all patients dying of renal failure.Not to treat may be kinder and wiser.Nevertheless, much of the present disquiet over selection of patients for dialysis and transplantation under the NHS is being voiced by organisa- tions representing patients.Their views and the whole policy need a full and frank debate in the open.
Surrogate embryo transfer combined with estrogen-progesterone therapy in monkeys. Implantation, gestation, and delivery without ovaries
Authors: G. D. Hodgen
Journal: JAMA (1983)

The collection of in vivo fertilized monkey embryos by lavage of the normal donor's uterotubal lumens and transfer of these surrogate embryos to the uterotubal environs of long-term castrate female monkeys is described. Sequential estrogen-progesterone replacement therapy that mimics the natural ovarian-menstrual cycle was administered to the recipients, causing the development of proliferative and secretory endometrium to accommodate the perinidatory events leading to successful placentation and embryogenesis. Retrograde irrigation of the uterotubal lumens of 23 normal intact donors was performed three to four days after the estimated time of ovulation, coitus, and fertilization. Of the 17 embryos or eggs collected, some were apparently healthy, as assessed by microscopic inspection, whereas others were obviously degenerating. Eleven surrogate embryos were transferred to steroid-treated, long-term castrate female recipients; four viable pregnancies were detected by measurement of chorionic gonadotropin, all concluding with uneventful deliveries of normal live neonates at term. These findings demonstrate the feasibility of establishing and maintaining normal pregnancy by combining surrogate embryo transfer with an exogenous steroid hormone regimen, even in the complete absence of ovarian function. The clinical implications of these primate studies may be far-reaching because they indicate new potential for childbearing by otherwise infertile or sterile women who have a competent uterus but lack the hormonal milieu provided by ovarian follicular maturation and corpus luteum function in the normal menstrual cycle. (<i>JAMA</i>1983;250:2167-2171)
THE MATERIA MEDICA COLLECTION OF THE SMITHSONIAN INSTITUTION.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal