tbuckley/cabot-search huggingface dataset:
A medical history of the Spanish Habsburgs. As traced in portraits
Authors: G. P. Hodge
Journal: JAMA (1977)

From the 13th century until well into the 20th, the Habsburgs were one of the great powers in Europe—for most of this time, the leading dynasty. To preserve the purity of the line, marriages between uncles and nieces, aunts and nephews, and cousins were commonplace. As a consequence, genetic complexities developed, and the famous prognathic "Habsburg jaw," among other noticeable traits, was passed down to succeeding generations. Never has a dynasty been so well documented in paintings, and their portraits provide an unusually complete series of medical illustrations that show the facial characteristics that marked the family in general. The observations are confirmed and extended by information from modern medical sources as well as from the medical records that date to the Habsburgs' own times. (<i>JAMA</i>238:1169-1174, 1977)
Uncertainty-Reply
Authors: Mark L. Cohen
Journal: JAMA (1984)

<h3>In Reply.—</h3> I agree with Dr Davison that patients often press physicians for definite answers when none are to be had. This pressure also frequently arises from within, as a result of training that emphasizes correct answers and does not adequately prepare physicians to deal with the uncertainties of medicine. The answer to Dr Davison's complaint lies, at least in part, in helping the patient to accept an incomplete or indefinite answer. To my mind, the best person to do this is a physician who is comfortable with his or her own uncertainty and who can thereby provide comfort and support even when answers are lacking. Incidentally, a number of correspondents have requested the source of the cartoon mentioned in my essay, in which a physician asked that a patient's question be rephrased as a multiple choice. I saw it on a bulletin board at the Pennsylvania State University College
Esophageal involvement with mediastinal granuloma
Authors: R. J. Dukes
Journal: JAMA (1976)

A review of 95 patients seen at the Mayo Clinic with mediastinal granuloma indicated that ten (10.5%) had esophageal involvement. The primary complaint was dysphagia. Esophageal roentgenographic features included compression, stricture, diverticulum, sinus tract formation, and tracheoesophageal fistula. An esophagogram should be included in the workup of any patient with suspected mediastinal granuloma. (<i>JAMA</i>236:2313-2315, 1976)
Experiences with Contact Lenses in Unilateral Aphakia
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Kupffer Cell Production of Cytokine–Induced Neutrophil Chemoattractant Following Ischemia/Reperfusion Injury in Rats
Authors: N Hisama, Y Yamaguchi, T Ishiko, N Miyanari, O Ichiguchi, M Goto, K Mori, K Watanabe, K Kawamura, S Tsurufuji, M Ogawa
Journal: Hepatology (1996)

We investigated the role of hepatic macrophages in the inflammatory response following reperfusion injury by blocking Kupffer cell phagocytosis with gadolinium chloride (GdCl3). Liver ischemia was induced in rats by occluding the portal vein for 30 minutes. A bolus of GdCl3 (7 mg/kg) was injected intravenously 1 and 2 days before surgery. The serum levels of cytokine–induced neutrophil chemoattractant (CINC) in untreated rats increased following reperfusion, peaked after 6 hours, and then gradually decreased. GdCl3 or heparin alone significantly decreased the serum levels of CINC ( P &lt; .05). In addition, pretreatment with GdCl3/heparin further inhibited the rise in the serum levels of CINC following reperfusion compared with those in untreated animals ( P &lt; .01). The in vitro production of CINC by Kupffer cells, obtained from animals pretreated with heparin or GdCl3, was significantly lower than that of cells isolated from untreated animals. Pretreatment with GdCl3/heparin further decreased CINC production by Kupffer cells compared with that of cells from animals that were pretreated with heparin or GdCl3 alone. The expression of CINC transcripts in Kupffer cells or in liver tissue peaked 3 hours after reperfusion in untreated animals. Pretreatment with heparin, GdCl3, or both significantly decreased the levels of CINC messenger RNA (mRNA) transcripts. Pretreatment with heparin, GdCl3, or GdCl3/heparin significantly decreased the number of neutrophils that accumulated in the liver 24 hours following reperfusion, compared with those in untreated animals. These results suggest that Kupffer cells release CINC and may play an important role in early neutrophil infiltration into the liver following ischemia/reperfusion.
American Thoracic Society/Centers for Disease Control and Prevention/Infectious Diseases Society of America: Controlling Tuberculosis in the United States
Journal: American Journal of Respiratory and Critical Care Medicine (2005)

During 1993-2003, incidence of tuberculosis (TB) in the United States decreased 44% and is now occurring at a historic low level (14,874 cases in 2003). The Advisory Council for the Elimination of Tuberculosis has called for a renewed commitment to eliminating TB in the United States, and the Institute of Medicine has published a detailed plan for achieving that goal. In this statement, the American Thoracic Society (ATS), Centers for Disease Control and Prevention (CDC), and the Infectious Diseases Society of America (IDSA) propose recommendations to improve the control and prevention of TB in the United States and to progress toward its elimination. This statement is one in a series issued periodically by the sponsoring organizations to guide the diagnosis, treatment, control, and prevention of TB. This statement supersedes the previous statement by ATS and CDC, which was also supported by IDSA and the American Academy of Pediatrics (AAP). This statement was drafted, after an evidence-based review of the subject, by a panel of representatives of the three sponsoring organizations. AAP, the National Tuberculosis Controllers Association, and the Canadian Thoracic Society were also represented on the panel. This statement integrates recent scientific advances with current epidemiologic data, other recent guidelines from this series, and other sources into a coherent and practical approach to the control of TB in the United States. Although drafted to apply to TB-control activities in the United States, this statement might be of use in other countries in which persons with TB generally have access to medical and public health services and resources necessary to make a precise diagnosis of the disease; achieve curative medical treatment; and otherwise provide substantial science-based protection of the population against TB. This statement is aimed at all persons who advocate, plan, and work at controlling and preventing TB in the United States, including persons who formulate public health policy and make decisions about allocation of resources for disease control and health maintenance and directors and staff members of state, county, and local public health agencies throughout the United States charged with control of TB. The audience also includes the full range of medical practitioners, organizations, and institutions involved in the health care of persons in the United States who are at risk for TB.
Inhibition of in-stent restenosis by the Quanam drug eluting polymer stent; Two year follow-up Eberhard Grube, Ulrich Gerckens, Sascha Rowold, Ralf M�ller, Guido Selbach, J�rn Stamm, Manfred Staberock. Heart Center Siegburg, Siegburg, Germany
Journal: Journal of the American College of Cardiology (2001)
Fibrogenesis
Authors: J. S. Harington
Journal: Environmental Health Perspectives (1974)

A review of fibrogenesis by asbestos fibers is given. There is nothing to indicate that the fibrogenic effects of inhaled asbestos fibers should differ in any way from those of ingested asbestos. Recently, ingestion has assumed some importance concerning human exposure. Three sections dealing with the process of fibrogenesis are covered: the first deals with in vitro fibrogenesis, in particular the interrelation of macrophages damaged by dusts and the subsequent laying down of collagen by fibroblasts in culture; the second deals with in vivo fibrogenesis after the inoculation of extracts of silica-treated macrophages into various animals, and the third, with the fibrogenicity of a wide variety of mineral fibers in man and experimental animals.Recent studies described in the first section of the present review appear to offer a better understanding of the effects of macrophages on fibroblasts after tissue damage of various kinds has occurred.
Intravenous Nisentil and Lorfan in Dental Anesthesia: Report on 2,000 Cases
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Injuries
Authors: Bahman S. Roudsari
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PUB044 TIM-3 Protein Expression in Non-Small Cell Lung Cancer and Its Relationship with PD-1/PD-L1 and Tumor-Infiltrating Lymphocytes
Authors: Yayi He, Leslie Rozeboom, Christopher Rivard, Rafal Dziadziuszko, Kim Ellison, Hui Yu, Caicun Zhou, Fred R. Hirsch
Journal: Journal of Thoracic Oncology (2017)
ANTICIPATION IN INHERITANCE OF DIABETES
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AMINOPTERIN IN THE TREATMENT OF ACUTE LEUKEMIA
Authors: P. W. C.
Journal: Annals of Internal Medicine (1949)

ExcerptThe inhibition of the biological activity of an essential metabolite by compounds which are structurally related to it is now a well known phenomenon. The underlying principles believed to be involved and their importance in the study of fundamental metabolic processes have previously been discussed in this journal.1Folic acid (pteroyl glutamic acid) and its specific antagonists constitute one of the most carefully studied examples of this relationship. By an antagonist in this sense is meant a substance which will inhibit the growth ofLactobacillus caseiin a suitable culture medium containing barely adequate amounts of folic acid, but whose...
Clarification of Sentence
Authors: Bronwyn Kingwell, Anuradha Aggarwal, Kellie D'orsa, Melissa Dmu, Anthony Formosa, Ravi Savarirayan, Anthony Dart
Journal: JAMA (2015)

1 We do not believe that management guidelines for Marfan syndrome have been changed as a result of this small clinical trial.While clinical governance procedures have been strengthened since publication of this study, the Institute has commenced a review with the purpose to further strengthen current audit practices and to minimize any possible risk of recurrence of such behavior.
Antigenic Variation of Recent Influenza A(H3N2) Viruses
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ELECTRICAL STORM IN CHAGAS HEART DISEASE PATIENTS WITH IMPLANTABLE CARDIOVERTER DEFIBRILLATOR - CLINICAL PREDICTORS, OUTCOME AND ARRHYTHMIC CHARACTERISTICS: A PROSPECTIVE REGISTRY FROM A UNIVERSITY HOSPITAL
Authors: Maria Licia Ribeiro Cury Pavao, Elerson Arfelli, Adilson Scorzoni Filho, Rafael Brolio Pavao, Antonio Pazin Filho, Jose Antonio Marin Neto, André Schmidt
Journal: Journal of the American College of Cardiology (2020)
Studies on Hemoglobin: I. Antigenic Properties of Human, Canine and Rabbit Hemoglobin Solutions
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract P143: Young Women are Most Susceptible to the Effects of Smoking on Adverse Cardiovascular Events
Authors: Cherie R Rooks, Danny Eapen, Amit Shah, Pankaj Manocha, Riyaz Patel, A. Maziar Zafari, Arshed Quyyumi, Viola Vaccarino
Journal: Circulation (2012)

Background . Although overall rates of smoking have declined in the U.S. population, such decline has been less in women than in men, and sex differences in smoking-related morbidity and mortality from coronary artery disease (CAD) may also exist. The purpose of this study was to determine sex and age-specific differences in the relationship between smoking and adverse cardiovascular events in patients referred for CAD evaluation. Methods . We examined 261 current smokers and 1,561 non-smokers who underwent coronary angiography for suspected CAD. Patients were followed for repeat hospitalization or death related to major adverse cardiovascular events (MACE). CAD severity was scored based on the Coronary Artery Surgery Study scoring system. Results . Smokers were more likely to be men (64%) and &lt;60 years of age (62%). After a median follow-up of 2.4 years, 148 (24%) women and 345 (29%) men experienced MACE. The adjusted hazard ratio for MACE was &gt;10-fold in women smokers &lt;60 yrs than non smoking counterparts (Table 1), and remained significant after adjusting for CAD severity. No significant association was found in men &lt;60 yrs or in older women or older men (sex, age and smoking interaction: p=0.03). Conclusions . Younger women referred for coronary evaluation appear to be more susceptible to the adverse cardiovascular effects of smoking than men or older women. Our results suggest potential sex differences in CAD pathophysiology and prognosis and emphasize the need to address smoking behavior in all patients, particularly young women.
P05.33 Extra-articular tenosynovial giant cell tumor of diffuse type in the temporal area with brain parenchymal invasion
Authors: Y Park, C Woo, M, H Moon, B Moon, S You
Journal: Neuro-Oncology (2018)

Tenosynovial giant cell tumor of diffuse type is a locally aggressive neoplasm that most commonly arises in the lower extremities. However, pure extra-articular TGCT of diffuse type invading the brain parenchyma of the temporal area without involvement of the joint has not been reported to date. Herein, we report for the first time a case of an extra-articular tenosynovial giant cell tumor of diffuse type in the temporal region with brain parenchymal invasion. Imaging studies revealed an intracranial expansile mass in the temporal bone without involvement of the temporomandibular joint. The unusual location of the tumor without involvement of the joint and the presence of brain parenchymal invasion made this case challenging to diagnose. The patient underwent temporal craniotomy, and the mass was completely removed. The patient underwent temporal craniotomy, and the mass was completely removed. The tumor had invaded the cerebral parenchyma of the temporal lobe; it showed adhesion to the adjacent dura and no association with the adjacent joint. The cut section of the mass was solid and yellow to brown with necrosis and hemorrhage. Microscopically, the tumor showed densely cellular sheets of mononuclear cells, irregularly distributed osteoclast-like giant cells, and hemosiderin pigments. Specifically, the mononuclear cell population was composed of small polygonal or spindle cells with pale eosinophilic cytoplasm and large mononuclear cells with ovoid or kidney-shaped nuclei displaying prominent nucleoli and vesicular chromatin, which exhibited little pleomorphism. The tumor cells were positive for CD68 on immunohistochemical staining. Most extra-articular tumors present as a periarticular mass with frequent involvement of the adjacent joint and cystic lesions in the adjacent bone, although on rare occasions, these lesions can be purely extra-articular.Wide excision is the treatment of choice; however, complete excision of the lesion is often impaired by the need to save an adjacent joint. Therefore, radiotherapy is recommended.
Youth pregnancy: a community solution
Authors: J. S. Marks
Journal: JAMA (1987)

The problem of preventing teen pregnancies has been especially perplexing in the United States. Despite evidence of recent declines, we have one of the highest rates of teen pregnancy in the developed world, and the economic costs of teen pregnancy are staggering. In 1985, $16.65 billion was spent on families begun when the mother was a teen; virtually all of those costs are associated with public assistance including Aid to Families With Dependent Children, Medicaid, and food stamps.<sup>1</sup> Educational efforts to offset the human and economic costs that attend teen pregnancies face formidable barriers. One is a marketing issue: sex sells everything. Sexual attractiveness is coupled with everything from independence to worldly sophistication and forms a predominant theme in every nook and cranny of commercial communication. These themes get the attention of adults and teens alike, but are especially alluring to adolescents who are grappling with their identity and