tbuckley/cabot-search huggingface dataset:
Randomized trial of early integrated palliative and oncology care.
Authors: Joseph A. Greer, Areej El-Jawahri, William F. Pirl, Vicki A. Jackson, Elyse R. Park, Anthony Back, Alona Muzikansky, Mihir Kamdar, Simone Rinaldi, Juliet Jacobsen, Emily R. Gallagher, Joel Fishbein, Justin Eusebio, Harry VanDusen, Jennifer S. Temel
Journal: Journal of Clinical Oncology (2016)

104 Background: Early palliative care (PC) improves outcomes in patients with newly diagnosed metastatic non-small cell lung cancer (NSCLC) and in patients identified by clinicians as having poor prognosis, advanced cancer. We evaluated the impact of early, integrated palliative and oncology care in patients with newly diagnosed lung and gastrointestinal (GI) cancer. Methods: Between 5/2/11 and 7/20/15, we randomly assigned patients with newly diagnosed incurable lung (NSCLC, small cell, mesothelioma) or GI (pancreas, hepatobiliary, gastric, esophageal) cancer to PC integrated with oncology care (monthly visits with PC) or usual oncology care. We used the Functional Assessment of Cancer Therapy-General (FACT-G) to assess quality of life (QOL) and the Patient Health Questionniare-9 (PHQ-9) for mood at baseline, weeks 12 and 24. We also assessed patients’ coping styles (Brief COPE), perceptions of likelihood of cure and communication about end-of-life (EOL) preferences. To evaluate intervention effects on patient-reported outcomes, we performed chi square tests and linear regression, controlling for baseline values and clinical factors. Results: We randomized 350 patients (175 per group), including 191 lung and 159 GI cancer patients. Patients assigned to early PC had higher QOL (B = 5.36, 95% CI: 2.04 to 8.69, p = 0.002) and less depression on the PHQ-9 (B = -1.17, 95% CI: -2.33 to -0.01, p = 0.048) at 24 weeks, but not at 12 weeks. Also at 24 weeks, the intervention group was significantly more likely to report using active and engaged coping styles compared to the usual care group (B = 1.09, 95% CI: 0.23 to 1.96, p = 0.013). Similar proportions of patients at 24 weeks reported that their cancer was unlikely to be cured (36/105 [33.6%] in PC and 43/115 [37.4%] in usual care) but more patients assigned to early PC reported they discussed their EOL preferences (35/116 [30.2%] versus 17/117 [14.5%], p = 0.004). Change in QOL over time differed between the lung and GI cancer cohorts. Conclusions: Early PC improved QOL, mood, coping, and the frequency of EOL discussions in patients with newly diagnosed lung and GI cancer. The benefits of the integrated care model extend to other populations with advanced disease and include improved communication about EOL care. Clinical trial information: NCT01401907.
Film Reviews
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sixth International Symposium on Medical Virology
Journal: JNCI Journal of the National Cancer Institute (1986)

Sixth International Symposium on Medical Virology Get access JNCI: Journal of the National Cancer Institute, Volume 77, Issue 1, July 1986, Page 310, https://doi.org/10.1093/jnci/77.1.310 Published: 01 July 1986
PLACENTA ACCRETA
Authors: Rex I. Smith
Journal: JAMA (1942)

Placenta accreta is a serious but fortunately a rare complication of labor. Meyer and Ashworth<sup>1</sup>found 118 authentic cases after careful search of the literature up to 1940. The reported incidence of this condition differs greatly, varying from 1 in 3,000 to 1 in 40,000 deliveries. As a rough estimate, it probably occurs about once in every 10,000 deliveries. The chief pathologic change in placenta accreta is a complete or partial absence of the decidua basalis, which allows the villi to burrow directly into the uterine musculature and prevents separation of the placenta after delivery. Any condition producing primary atrophy of the endometrium may be a predisposing factor. Conditions which have been implicated include previous manual removal of the placenta, too thorough curettage, submucous fibromyomas, endometritis and possibly dyshormonism, since hormones play an important role in the formation of the decidua. The chief symptom of this condition is brisk
Deaths from asthma in young people.
Authors: J Harris, J Mahony, J Mccann
Journal: BMJ (1972)

present the lesions become more prominent, oedematous, and brilliant in colour.2The rash is more prominent on the flanks, abdomen, shoulders, upper arms, and back and has a special predilection for the palms and soles.3There may well be associated slightly tender superficial lymphadenopathy.If these points are remembered there is little diagnostic difficulty, as the maculopa- pular eruption associated with ampicillin therapy starts most commonly on the exten- sor aspects of the limbs, especially over the knees and ankles, is uncommonly associated with any general reactions,' and, most im- portant of all, rarely occurs less than four days after the start of ampicillin therapy.5 -We are, etc.,
Incorrect Author for Reference.
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effects of Subanesthetic Concentrations of Enflurance on Rat Pregnancy and Early Development
Authors: C. Denny Strout, Michael L. Nahrwold, Margaret D. Taylor, Ian S. Zagon
Journal: Environmental Health Perspectives (1977)

Anesthetic pollutants in the operating room have been implicated in producing spontaneous abortion in exposed personnel and congenital malformations among their offspring.To test the effects of trace concentrations of enflurane on pregnancy, rats were exposed to two levels (10.7 and 63.7 ppm) of the anesthetic for 8 hr daily from days 1 to 19 of pregnancy.Litter sizes were not affected but birth weights of exposed offspring were slightiy higher than controls.During lactation, cross-fostering studies were per- formed.Exposed offspring were housed with nonexposed mothers and vice versa to determine if exposure during pregnancy affected early development.Weights at 7, 14, and 21 days of age did not differ among the offspring in the lower dose experiment.Weights of the cross-fostered groups in the high dose experi- ment were decreased at day seven compared to controls.In the same experiment, exposed offspring housed with exposed mothers were heavier than controls on day 21 of lactation.The modest nature of these alterations suggests that enflurane has littie or no gross effect on rat pregnancy and postnatal development.
Warnings on Interaction Between Air Bags and Rear-Facing Child Restraints
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An annotated algorithm approach to clinical guideline development
Authors: D C Hadorn, K McCormick, A Diokno
Journal: JAMA (1992)

The Urinary Incontinence in Adults Guideline Panel facilitated the ready elucidation of its guideline's management recommendations through the use of an annotated algorithm approach. The algorithms created as part of this guideline differ from previous algorithms in two ways: (1) they employ systematic annotation to link explicitly the algorithms' recommendations to the literature, and (2) they contain patient counseling and decision nodes to depict the major preference-dependent decision or branch points in the algorithm. We believe that these two innovations can help ensure the clinical validity of guidelines' algorithms while preserving appropriate clinical flexibility and respecting patient preferences.
Misrepresentation of Academic Accomplishments by Applicants for Gastroenterology Fellowships
Authors: Munir E. Nassar
Journal: Annals of Internal Medicine (1996)

Letters15 February 1996Misrepresentation of Academic Accomplishments by Applicants for Gastroenterology FellowshipsMunir E. Nassar, MDMunir E. Nassar, MDBrockport, NY 14420Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-124-4-199602150-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The report by Sekas and Hutson [1] and the editorial by Kimball [2] raise disquieting issues related to the academic and professional integrity of physicians, professors, research fellows, and directors of research laboratories. Despite the impressive statistics (34.1% of applicants' research activities could not be confirmed, and 30.2% of applicants' presumed published works were not verifiable) [1] findings of falsification of credentials (12%) and employment applications (5%) [2], this type of information may not reveal the entire truth or determine why certain fellows and physicians indulge in such presumed activities. Fraudulent academic misrepresentation is a two-way street ...References1. Sekas G, Hutson WR. Misrepresentation of academic accomplishments by applicants for gastroenterology fellowships. Ann Intern Med. 1995; 123:38-41. Google Scholar2. Kimball HR. Credentials misrepresentation: another challenge to professionalism. Ann Intern Med. 1995; 123:58-9. Google Scholar Author, Article, and Disclosure InformationAffiliations: Brockport, NY 14420 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 February 1996Volume 124, Issue 4Page: 457KeywordsFellowshipsResearch laboratories Issue Published: 15 February 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Pneumoperitoneum
Authors: D. Leys
Journal: BMJ (1944)

hepatoma (Dardinski, 1932), or recent thrombosis of a splenic vein (Rhame, 1928).It is probable that in some cases there is an arteriolar rupture.The splenic artery degenerates early.Black states that at 36 years 50% of spleens show degenerative changes.The splenic artery may show gross degenerative changes with aneurysm formation when the rest of the arteries in the body are normal (Parsons, 1937).In the case reported aboye the spleen was not abnormally mobile-there was no evidence of venous obstruction, and in view of the arteriolar degeneration present it is possible that the haemorrhage was arteriolar in origin. SummaryA further case of spontaneous rupture of an apparently normal spleen is reported and a brief review of the literature is given.It is suggested that rupture is secondary to an intrasplenic'haemorrhage.It is unlikely that any one common cause of the haemorrhage will be found to explain all cases.
Removal of anti-Galα1,3Gal xenoantibodies with an injectable polymer
Authors: Andreas G. Katopodis, Richard G. Warner, Rudolf O. Duthaler, Markus B. Streiff, Armin Bruelisauer, Olivier Kretz, Birgit Dorobek, Elke Persohn, Hendrik Andres, Alain Schweitzer, Gebhard Thoma, Willy Kinzy, Valerie F.J. Quesniaux, Emanuele Cozzi, Hugh F.S. Davies, Rafael Mañez, David White
Journal: Journal of Clinical Investigation (2002)

Preformed and elicited Ab's against the Galα1,3Gal terminating carbohydrate chains (αGal Ab's) are the primary cause of hyperacute and acute vascular xenograft rejection in pig-to-primate transplantation. αGal Ab's are produced by long-lived Ab-producing cells that are not susceptible to pharmacological immunosuppression. We reasoned that antigen-specific elimination of αGal Ab's might be achieved in vivo by systemic administration of nonimmunogenic polyvalent αGal structures with high avidity for αGal Ab's. We devised GAS914, a soluble trisaccharide-polylysine conjugate of approximately 500 kDa that effectively competes for αGal binding by αGal IgM (IC50, 43 nM) and IgG (IC50, 28 nM) in vitro. Injections of GAS914 in cynomolgus monkeys, at the dose of 1 mg/kg, resulted in the immediate decrease of more than 90% of circulating αGal Ab's and serum anti-pig cytotoxicity. In baboons, repeated injections of GAS914 effectively reduced both circulating αGal Ab's and cytotoxicity over several months. Studies with [14C]GAS914 in rhesus monkeys and Gal–/– mice indicate that GAS914 binds to circulating αGal Ab's and that the complex is quickly metabolized by the liver and excreted by the kidney. Remarkably, posttreatment αGal Ab titers never exceeded pretreatment levels and no sensitization to either αGal or the polylysine backbone has been observed. Furthermore there was no apparent acute or chronic toxicity associated with GAS914 treatment in primates. We conclude that GAS914 may be used therapeutically for the specific removal of αGal Ab's.
Guidelines for total parenteral nutrition
Authors: M. E. Shils
Journal: JAMA (1972)

Total parenteral nutrition is a procedure capable of maintaining patients in good condition for prolonged periods while underlying disease is being treated. Achievement of this goal presents problems in formulation, in sterile preparation, and in safe administration of the nutrient solution. A practical program is outlined for simple, inexpensive, and sterile preparation of standard solutions in closed systems. Indications and precautions for this potentially life-saving treatment are discussed together with consideration of routes of administration, ancillary equipment, and nutrient requirements for total parenteral nutrition.
The growing brown plague
Authors: W. H. Foege
Journal: JAMA (1990)

TWO BASIC factors explain why tobacco causes so much suffering and early death, and why that trend is getting worse for most of the world, as demonstrated in this issue of<i>JAMA</i>. Those factors are addiction and greed. Addiction to tobacco has become better understood in recent years. It is a powerful force that often negates the best intentions of even the most independent, self-reliant, and self-disciplined of people. Accurate knowledge, good intentions, and determined resolutions each night dissolve in a reflex puff of smoke in the morning. Despite the statements of the tobacco industry and the decisions by some legal jurisdictions, free will is not within the power of most smokers, and an affirmative choice is not possible each day. The window of free will, for most smokers, is short, usually early in life before what is thought of as the age of consent, and exercised in an atmosphere
Shock
Authors: John J. Byrne
Journal: New England Journal of Medicine (1966)

Secondary Treatment Acidosis leads to diminished vascular and cardiac tone and should be corrected by sodium bicarbonate solution or tris-buffer. However, acidosis is a reflection of the diminished tissue profusion, and its treatment is useless unless the latter is improved. Tris-buffer is administered as a 0.3 M solution (36 gm. in 1000 ml. of distilled water), and can be administered over a period of two or three hours. It requires frequent monitoring of arterial and venous pH, arterial and venous carbon dioxide tension, blood glucose and electrolytes. A formula may be used as a guide for such therapy (mEq. of . . .
Clinical Lectures on Stricture of the Urethra
Authors: B. Hill
Journal: BMJ (1879)

THE URETHRA? [N the remarks I am about to offer you concerning stricture of the urethra, I shall mainly direct your attention to the conditions which relate to close or narrow stricture; but, before doing so, I shall advert to the natural width or natural variations in width of the urethra-for two reasons: one, because I believe a knowledge of that width is neces- sary to appropriate treatment of the stricture; and the other, because I think the urethra is commonly supposed by surgeons to have a narrower calibre than it really possesses.On the other hand, it must be borne in mind that the urethra, when not in use as a tract for the urine or semen, is not an open tube at all, but a chink of which the sides are in close apposition.This condition is well seen in a transverse section of
Evaluation of a New Mumps Vaccine
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
End of an era.
Journal: BMJ (1969)

MEDITIJSHRNAmussel Dreissena polymorpha, and this test may prove helpful in the future, though at present unsuitable for routine use.Also of interest is the discovery of metachromatic stain- ing material in cultured skin fibroblasts and white blood cells from patients with disease and carriers of it, but this remains too non-specific for use in genetic counselling.The three underlying features of the disease are: an abnormality in the electrolytes of the secretion from mucus glands; abnormal physicochemical behaviour of the mucus produced;
Shorter recurrent lesion length after localized intracoronary radiation in the gamma I study: A partial response to radiation Mark A. Grise, Alexandra Lansky, Martin B. Leon, Jeffrey W. Moses, Richard Kuntz, Barry George, James Hermiller, Bryan Kluck, Dennis Donohoe, Prabhakar Tripuraneni, Shirish Jani, Paul S. Teirstein. Scripps Clinic, La Jolla, CA
Journal: Journal of the American College of Cardiology (2001)
Correction: The size, morphology, site, and access score predicts critical outcomes of endoscopic mucosal resection in the colon
Authors: Mayenaaz Sidhu, David Tate, Lobke Desomer, Gregor Brown, Luke Hourigan, Eric Lee, Alan Moss, Spiro Raftopoulos, Rajvinder Singh, Stephen Williams, Simon Zanati, Nicholas Burgess, Michael Bourke
Journal: Endoscopy (2018)

Correction to:The size, morphology, site, and access score predicts critical outcomes of endoscopic mucosal resection in the colonEndoscopy 2018; 50(07): 684-692DOI: 10.1055/s-0043-124081
Association Intelligence
Journal: BMJ (1893)

progress of the Association, on tlle meetinlg at Newcastle in 1870, a history of the University of Durliam College of Medi- cine in Newcastle, notes on the medical curriculum of the University, a description of the College buildings, and of the local hospitals and infirmaries.The volume forms an interesting memento of the 61st annual meeting. SMALL-POX IN GREAT BRITAIN.THE small-pox admissions to hospital in London last week did not mliuch exceed 20, whilst the number of patients remaining under treatment oni Saturday were onily 221, a still further decrease on previous totals.The deaths were 2. In West Ham only a couple of fresh attacks were re- corded, but northward there were numerous occurrences in the Edmonton Union, more especially at Tottenham.In the Midlands, the centres last week were Birmingham and Leicester, with somiie half dozen cases between them; Bradford, with nearly a score of attacks, and Wakefield being the Yorkshire towns chiefly iimiplicated: in the north Tynemouth again had multiple cases; and in Lancashire, Salfolrd had 5 cases and 3 deaths, Manchester a single attack and onie death, and Oldham aind Stalybridge a couple of cases each.The decrease in the Manchester epidemlc is plainly shown in Dr. Tatham's report for the second quarter of this year, wherein 89 attacks occurred in April, 102 in May, and 34 only in June, a total of 215, against 385 in the first quarter of the year, whilst tlle fresh weekly occurrences during July and the present miionth have been quite insignificant in number.
Comparison of Long-Term Neurocognitive Outcomes in Young Children With Acute Lymphatic Leukemia Treated With Cranial Radiation or High-Dose or Very High-Dose Intravenous Methotrexate
Authors: Ian J. Cohen
Journal: Journal of Clinical Oncology (2007)

Fortunately, very few childhood cancer survivors commit suicide, but the increased risk attributable to childhood cancer, and the presence of a small but significant minority of survivors (12.8%) with suicidal symptoms identified in our study, point to the critical need to address psychological outcomes among childhood cancer survivors.Future research in this area should focus on identifying risk factors for suicidality that may be used to guide the development of appropriate methods of assessment and intervention.