tbuckley/cabot-search huggingface dataset:
Abstract 1948: Functional profiling of signal transduction pathway proteins in gastric cancer (GC) patients
Authors: Tani Lee, Jeeyun Lee, Katya Magonova, Won Ki Kang, Gulia Harvie, Robert Barham, Glen Leesman, Phillip Kim, Sharat Singh, Sung Kim
Journal: Cancer Research (2011)

Abstract Although gastrectomy is the only curative treatment in gastric cancer (GCA) patients, a high recurrence rate ranging from 40 ∼ 60% following curative surgery still accounts for poor overall survival. In order to further improve survival, there is an urgent need to identify reliable molecular prognostic markers for survival or recurrence following adjuvant chemoradiation therapy. With the advent of molecularly targeted therapy in cancer care, profiling of pathway proteins for targeted drug is of utmost importance. Hence, we have developed a multiplexed immunoassay platform for functional profiling of the signal transduction pathway proteins using a multiplexed immuno-microarray platform. A multiplexed protein microarray platform, Collaborative Enzyme Enhanced Reactive-immunoassay (CEER) that utilizes the formation of a unique immuno-complex requiring co-localization of two detector-antibodies (d-abs) has been utilized to profile targetable biomarkers in 447 fresh frozen tumor tissues procured during surgical procedure from GCA patients with localized disease. The collaboration between two channeling-enzymes conjugated on two d-abs in proximity enables the profiling of the target proteins with extreme sensitivity and specificity in multiplexed fashion. As CEER can also be configured for each specific target protein, it allows differential detection of truncated targets (i.e., p95HER2) from their normal counter parts (i.e., HER2). Here we report the profiling of HER2, p95HER2, HER1, HER3, PI3K, cMET, Shc and IGF1R in GCA for their levels of expression and phosphorylation. Approximately 12% of patients in this cohort expressed high levels of HER2. Varying levels of truncated HER2 were detected in 7.1% (27/447) of GCA pts. HER3 were found in approximately 40% of pts. The prevalence of biomarker expression/activation along with the outcome of unsupervised clustering analysis of signaling molecules revealing diverse and distinct disease subtypes will be presented. The treatment of recurrent or metastatic GC may be optimized based on patient-specific functional profiling of biomarker leading to patient-tailored treatment strategies. In addition, the incidence of alteration in transduction pathway proteins may guide oncologists for further clinical development of targeted therapies or combined / sequenced targeted therapies. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1948. doi:10.1158/1538-7445.AM2011-1948
Editorial Board
Authors: Bruce Thiers, Dirk Elston, Detra Davis, Jack Lesher, Nikki Levin, Mary Spellman, Jeffrey Weinberg, Dermatologic Surgery, Clifford Perlis, Julie Prendiville, Frcpc Dermatopathology, John Maize, Social Media, Emily Altman, Robert Dellavalle, J Smith, Editors Emeritus, Richard Dobson, Jeffrey Bernhard, Calvin Mccall, Brett Sloan, James Solomon, Stephen Tyring, George Hruza, Pediatric Dermatology, Kelly Cordoro, Dermatopathology Carlson, Tammie Ferringer, Cyberdermatology Consultant, Daniel Siegel, Clara Kim, Bryan Anderson, Salvador Arias-Santiago, Trisha Beute, John Binhlam, Diana Bolotin, Markus Braun-Falco, Nooshin Brinster, Patrick Carrington, Zoe Draelos, Nananamibia Duffy, Laura Ferris, David Fivenson, Joel Gelfand, Camille Introcaso, Nathaniel Jellinek, Jonathan Kantor, Matthew Kanzler, Kevin Kia, Kenneth Linden, Jason Lott, Omar Lupi, A2 June, J Am, Acad Dermatol
Journal: Journal of the American Academy of Dermatology (2016)
Effect of mouthpiece breathing on cardiorespiratory response to intense exercise.
Authors: K E Bloch, J Barandun, M A Sackner
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

Use of mouthpiece and noseclips after breathing pattern at rest and during moderate exercise. Our purpose was to extend observations on mouthpiece breathing to its effects on the cardiorespiratory response to intense exercise and to develop and validate an algorithm for computer-assisted analysis of breathing pattern recorded with respiratory inductive plethysmography. Six normal men performed incremental bicycle exercise to volitional exhaustion on two occasions with and without mouthpiece and noseclip. ECG and breathing pattern recorded with a respiratory inductive plethysmograph were analyzed manually and with computer assistance. Mouthpiece breathing increased tidal volume and respiratory cycle time by up to 63 and 33% respectively (p < 0.02) during mild exercise, but it did not alter performance, heart rate, or breathing pattern at maximal exercise. Mean differences between inductive plethysmographic and spirometric tidal volumes were < 5% during validation at rest and maximal exercise. Application of the proposed algorithm for semiautomatic breathing pattern analysis provided significant time savings with no loss in precision compared with manual analysis. In conclusion, in normal men, performance and breathing pattern during maximal exercise are not altered by a mouthpiece and noseclip, and accurate computer-assisted measurement of ventilation from external transducers may be performed even during intense exercise.
Neck dissections based on sentinel lymph node navigation versus elective neck dissections in early oral cancers: A randomized, multicenter, non-inferiority trial.
Authors: Yasuhisa Hasegawa, Kiyoaki Tsukahara, Seiichi Yoshimoto, Kouki Miura, Junkichi Yokoyama, Shigeru Hirano, Hirokazu Uemura, Masashi Sugasawa, Tomokazu Yoshizaki, Akihiro Homma, Kazuaki Chikamatsu, Mikio Suzuki, Akihiro Shiotani, Takashi Matsuzuka, Naoyuki Kohno, Masakazu Miyazaki, Isao Oze, Keitaro Matsuo, Shigeru Kosuda, Yasushi Yatabe
Journal: Journal of Clinical Oncology (2019)

6007 Background: The objective of the study is to evaluate the non-Inferiority of survival, the superiority of postoperative disability, and the complication of the neck in neck dissections based on sentinel lymph node navigation in early oral cancer patients, compared with standard selective neck dissections. Methods: This study was a randomized, multicenter, non-inferiority trial at 16 institutions in Japan. Eligibility criteria included histologically confirmed squamous cell carcinoma in the oral cavity; clinical categories T1 and T2, N0M0 by UICC TNM classification 7th edition, clinical depth of invasion (DOI) of T1 was over 4mm (defined as late T1); previously untreated; age at least 18 years; and written informed consent. We randomly assigned patients (1:1) to receive either sentinel lymph node biopsy (SNB) or standard selective neck dissections (ND) with stratification of T category (lateT1 vs T2) and subsite (tongue vs others). The primary endpoint was 3-year overall survival with a non-inferiority margin of 12%. Sentinel nodes (SNs) were detected using radioisotope method and examined with multislice frozen section analysis intraoperatively, following HE and cytokeratin stain for a final postoperative diagnosis. Patients with positive SNs had neck dissections in a one-stage or back up procedure. Results: Between November 2011 and January 2016, 271 patients were enrolled and randomized to SNB group (134 patients) and ND group (137 patients) with a median follow-up of 37 months (IQR 36-39). Pathological positive nodal status was 34% (46/132) in SNB group and 26% (34/133) in ND group (Chi-Square p = 0.10). 3-year overall survival in SNB group was 89% (95%CI 82-93%), which was non-inferior to that in ND group (86%, 95%CI 79-91%). 3-year relapse-free survival was 80% (95%CI 72-86%) in SNB group and 81% (95%CI 73-87%) in ND group. Arm abduction of postoperative 1 and 3 months in ND group was disturbed significantly compared with SNB group. Conclusions: SNB navigated ND could replace elective ND without survival disadvantage and reduce postoperative disability of the neck in patients with early oral cancer. Clinical trial information: 000006510.
ROME
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CHICAGO DIPLOMA MILLS.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Myxedema coma
Authors: S. R. Newmark
Journal: JAMA (1974)

MYXEDEMA coma is the extreme clinical expression of hypothyroidism. It is characterized by coma, hypothermia, cardiovascular collapse, hypoventilation, and severe metabolic derangements, including low serum sodium, hypoglycemia, and lactic acidosis. Mild to moderate hypometabolism, lethargy, and sleepiness secondary to untreated hypothyroidism is<i>not</i>myxedema coma and should not be treated as such. Generally, myxedema coma requires several years of untreated hypothyroidism to develop, and usually, it occurs in elderly people who have been without medical care. Before treatment for myxedema coma is initiated, other medical conditions causing similar signs and symptoms should be ruled out. Prognosis is guarded (greater than 50% mortality), and success depends upon prompt institution of appropriate therapy.<sup>1-3</sup> <h3>Treatment</h3><h3>Administration of Thyroid Hormone.—</h3> The rational course of therapy is to deliver<i>thyroid</i>hormone to the patient. However, myxedematous patients are frequently extremely sensitive to the metabolic effects of thyroid hormones and may sustain cardiac damage. Nevertheless, it
Bony ingrowth holds new 'joints' in place
Authors: C. Macek
Journal: JAMA (1982)

Methyl methacrylate, introduced to the orthopedic surgical world in the late 1950s by John Charnley, MB, FRCS, of the University of Manchester, England, revolutionized joint replacement because it provided a quick-drying cement as well as a cushion between bone and prosthesis. Still, most surgeons agree that the best bond between bone and implant is a biologic one, and this is the goal of several prosthetic devices on the market today—to achieve permanent bone ingrowth into an implant. "Over the past ten to 20 years it has evolved that the major problem with artificial joints of all types is the fixation of the joint to the bone, which tends to work loose over time," says Kenenth A. Krakow, MD, assistant professor of orthopedic surgery at The Johns Hopkins University School of Medicine and chief of orthopedic surgery at Loch Raven Veterans Administration Hospital, Baltimore. "You can imagine how it would feel
Fibrogenesis
Authors: J. S. Harington
Journal: Environmental Health Perspectives (1974)

A review of fibrogenesis by asbestos fibers is given. There is nothing to indicate that the fibrogenic effects of inhaled asbestos fibers should differ in any way from those of ingested asbestos. Recently, ingestion has assumed some importance concerning human exposure. Three sections dealing with the process of fibrogenesis are covered: the first deals with in vitro fibrogenesis, in particular the interrelation of macrophages damaged by dusts and the subsequent laying down of collagen by fibroblasts in culture; the second deals with in vivo fibrogenesis after the inoculation of extracts of silica-treated macrophages into various animals, and the third, with the fibrogenicity of a wide variety of mineral fibers in man and experimental animals. Recent studies described in the first section of the present review appear to offer a better understanding of the effects of macrophages on fibroblasts after tissue damage of various kinds has occurred.
Hepatitis A vaccines considered for licensing
Authors: C. Marwick
Journal: JAMA (1992)

TWO HEPATITIS A vaccines are being considered by the Food and Drug Administration for licensing. Studies indicating their safety and efficacy already have been reviewed by the Immunization Practices Advisory Committee at a meeting in the Centers for Disease Control, Atlanta, Ga. One of the vaccines is being developed by Merck Sharp &amp; Dohme, West Point, Pa; the other by Smith-Kline Beecham, Philadelphia, Pa. Both are cultivated from cell lines and inactivated with formalin. <h3>2658 Subjects</h3> The Merck product has been given to 2658 persons during safety and immunogenicity trials. "In general, the vaccine has been well tolerated with only the expected local and transient reactions at the injection site, and no serious adverse clinical experiences," says David R. Nalin, MD, Merck's clinical research director. The vaccine has now been tested in a double-blind, randomized, placebo-controlled trial in Monroe, NY (northwest of New York City), an area in which hepatitis
DIAPHRAGMATIC PLEURISY
Authors: H. B. WEISS
Journal: JAMA (1923)

One of the most trying and difficult symptoms to interpret is pain. When the pain is not felt by the patient at the site of its origin but is referred to other and perhaps distant parts of the body, the difficulty obviously increases. Such pain is referred pain and is found in diaphragmatic pleurisy. Capps,<sup>1</sup>by means of a series of ingenious experiments on man, demonstrated, in 1911, that the visceral pleura is not endowed with pain sense and that the parietal pleura is richly supplied with sensory fibers from the intercostal nerves; that irritation of the parietal pleura produces pain that is accurately localized by the individual over the spot irritated. He demonstrated, at the same time, thatthe diaphragmatic pleura receives its nerve supply from two sources, the phrenic nerve and the lower six intercostal nerves. The intercostal nerves supply the peripheral rim of the diaphragm anteriorly and
Phage Display-Directed Discovery of LEDGF/p75 Binding Cyclic Peptide Inhibitors of HIV Replication
Authors: Belete A. Desimmie, Michael Humbert, Eveline Lescrinier, Jelle Hendrix, Sofie Vets, Rik Gijsbers, Ruth M. Ruprecht, Ursula Dietrich, Zeger Debyser, Frauke Christ
Journal: Molecular Therapy (2021)

(Mol Ther. 20, 2064–2075; November 1, 2012) Following publication of the article, the authors realized that, in Figure 3a of the main manuscript and Supplementary Figure S5, errors occurred in the presentation of western blot images and splicing was not indicated in both the figures and respective figure legends. To correct the errors, the authors have provided a new file for Figure 3a based on a single experiment and western blot. The new data do not affect in any means the results and conclusions as published in the initial manuscript. For Figure S5 the authors have provided a new figure without splicing. Again, the new representation does not affect the conclusion and results. The figure legends do not require any change. The authors regret these errors.Figure S5Characterization of different cell lines stably expressing the cyclic peptides (CPs)View Large Image Figure ViewerDownload Hi-res image Download (PPT) Phage Display-directed Discovery of LEDGF/p75 Binding Cyclic Peptide Inhibitors of HIV ReplicationDesimmie et al.Molecular TherapyNovember, 2012In BriefThe interaction between the human immunodeficiency virus (HIV) integrase (IN) and its cellular cofactor lens epithelium-derived growth factor (LEDGF/p75) is crucial for HIV replication. While recently discovered LEDGINs inhibit HIV-1 replication by occupying the LEDGF/p75 pocket in IN, it remained to be demonstrated whether LEDGF/p75 by itself can be targeted. By phage display we identified cyclic peptides (CPs) as the first LEDGF/p75 ligands that inhibit the LEDGF/p75–IN interaction. The CPs inhibit HIV replication in different cell lines without overt toxicity. Full-Text PDF Open Archive
New efforts to keep adolescents tobacco-free
Authors: C. Marwick
Journal: JAMA (1996)

EFFORTS to discourage young people from taking up smoking are about to get a major impetus. A new organization, the Center for Tobacco-Free Kids, is being formed to focus its energies on changing the social environment and to attempt to influence public policies regarding the use of tobacco by teens. "We expect to be fully operational by June," said Matthew Myers, a Washington, DC, lawyer and well-known antitobacco activist, who will be the group's executive vice president. "We will work nationwide with a broad range of health education and community organizations to develop and implement antitobacco strategies at all levels of government." The new center will be headed by William Novelli, of the public relations firm of Porter, Novelli, who will oversee its media and communications efforts. In the past, the firm has conducted educational campaigns for such groups as the National Cancer Institute and National Heart, Lung, and Blood
Ischemic Retinopathy Caused by Severe Megaloblastic Anemia
Authors: Thomas Marrie, Charles Poser, George Bruyn
Journal: New England Journal of Medicine (2000)

The New Eng land Jour nal of Medicine ic fibrosis was excellent, but there was no discussion of what to do for patients who were infected with microorganisms that were resistant to all available antibiotics.The latter situation is not uncommon in clinical practice, and this would have been a perfect topic for discussion in one of the practice points.There is an excellent chapter on Lyme disease, but essentially nothing on Rocky Mountain spotted fever.This book would be a useful addition to the library of any infectious-disease consultant, and the practice points sections alone justify the purchase of the book despite its deficiencies.All will find the illustrations helpful, and reading all of the practice points will provide a working knowledge of many of the common infectious-disease problems.
Self-Reported Heart Disease and Stroke Among Adults With and Without Diabetes—United States, 1999-2001
Journal: JAMA (2003)

Heart disease and stroke are the first and third leading causes of death among U.S. adults. Adults with diabetes have a twofold to fourfold greater risk for dying from cardiovascular diseases than adults without diabetes. In addition, although the annual incidence of deaths attributed to cardiovascular diseases declined substantially among U.S. adults during 1970-1994, it decreased less among those with diabetes. To compare the prevalence of heart disease and stroke among adults with and without diabetes, CDC analyzed data from the 1999-2001 National Health Interview Surveys (NHIS). This report summarizes the results of that analysis, which indicate that the age-adjusted prevalence of heart disease and stroke is approximately two to three times greater among adults with diabetes than among adults without diabetes. Increased efforts are needed to prevent diabetes and reduce the prevalence of cardiovascular disease risk factors (e.g., hypertension and high cholesterol) in the United States, particularly among adults with diabetes.
THE DANGERS OF SANITARY OFFICIALS.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
INNOCUOUS INSOMNIA?RESPIRATORY GYMNASTICS IN PULMONARY TUBERCULOSIS.
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal