tbuckley/cabot-search huggingface dataset:
Biomarkers Predictive of Exacerbations in the SPIROMICS and COPDGene Cohorts
Authors: Jason D. Keene, Sean Jacobson, Katerina Kechris, Gregory L. Kinney, Marilyn G. Foreman, Claire M. Doerschuk, Barry J. Make, Jeffrey L. Curtis, Stephen I. Rennard, R. Graham Barr, Eugene R. Bleecker, Richard E. Kanner, Eric C. Kleerup, Nadia N. Hansel, Prescott G. Woodruff, MeiLan K. Han, Robert Paine, Fernando J. Martinez, Russell P. Bowler, Wanda K. O’Neal, Neil E. Alexis, Wayne H. Anderson, R. Graham Barr, Eugene R. Bleecker, Richard C. Boucher, Russell P. Bowler, Elizabeth E. Carretta, Stephanie A. Christenson, Alejandro P. Comellas, Christopher B. Cooper, David J. Couper, Gerard J. Criner, Ronald G. Crystal, Jeffrey L. Curtis, Claire M. Doerschuk, Mark T. Dransfield, Christine M. Freeman, MeiLan K. Han, Nadia N. Hansel, Annette T. Hastie, Eric A. Hoffman, Robert J. Kaner, Richard E. Kanner, Eric C. Kleerup, Jerry A. Krishnan, Lisa M. LaVange, Stephen C. Lazarus, Fernando J. Martinez, Deborah A. Meyers, John D. Newell, Elizabeth C. Oelsner, Wanda K. O’Neal, Robert Paine, Nirupama Putcha, Stephen I. Rennard, Donald P. Tashkin, Mary Beth Scholand, J. Michael Wells, Robert A. Wise, Prescott G. Woodruff
Journal: American Journal of Respiratory and Critical Care Medicine (2019)
5-Fluorouracil
Authors: H. R. Morris
Journal: JAMA (1962)

<h3>To the Editor:—</h3> InThe Journal(<b>181</b>:295 [July 28] 1962), in "Five Years Experience with 5-Fluorouracil," the following observation is made by the authors: "With the added experience gained in the treatment of over 1,000 patients, we do not feel there is anything to be gained by discussing with good-risk patients the mortality rate from 5-FU therapy, for the same reason that the well-trained surgeon refrains from discussing mortality rates of cholecystectomy with patients with cholecystitis." The analogy is dangerous, unwise, and philosophically, medicolegally, and scientifically indefensible. Any well-trained surgeon will not refrain from discussing mortality rates of cholecystectomy with patients with cholecystitis. Furthermore, the analogy between cholecystitis, a curable disease, and incurable cancer is poorly drawn. The acceptance of such an observation causes me to wonder how careful editorial scanning may be.
INTERNAL BLEEDING.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Rheumatism: Its Meaning and Its Menace.
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Increasing Habitat Suitability in the United States for the Tick that Transmits Lyme Disease: A Remote Sensing Approach
Authors: Agustín Estrada-Peña
Journal: Environmental Health Perspectives (2002)

The warnings about the spread of Ixodes scapularis, one of the vectors of Lyme disease, into the United States are based on reports about regional distribution and increasing local abundance.In a modeling approach, I used the recorded, current distribution of this tick and remotely sensed bioclimatic factors over the United States to establish the changes of habitat for this tick since 1982 and to detect the areas with factors adequate to support tick colonization.Results indicate the geographic expansion of areas with adequate habitat suitability in the period 1982-2000.A discriminant analysis of counties with different degrees of habitat suitability shows that the increase in winter temperatures and in vegetation vitality (as a direct consequence of higher rainfall) is key to habitat switch from unsuitable to suitable.
The Diagnosis and Treatment of Panic Disorder
Authors: W. Agras
Journal: Annual Review of Medicine (1993)

Panic attacks and panic disorder often first present in the emergency room or to the family practitioner. The presentation and differential diagnosis of this disabling disorder are described in this review, together with the etiology and health effects of the syndrome. Both medication and psychological treatments are described, as are the indications, side effects, and expected outcome for each therapy alone and in combination.
The Six-City Study: Examples of Problems in Analysis of the Data
Authors: B. G. Ferris, D. W. Dockery, J. H. Ware, F. E. Speizer, R. Spiro
Journal: Environmental Health Perspectives (1983)

This paper presents some of the results from cross-sectional analyses and studies during air pollution alerts obtained as a part of the Six-City Study, a longitudinal study of the respiratory effects of air pollution. These analyses illustrate some of the limitations and uncertainties of epidemiologic studies. For example, an earlier report noted increased respiratory illness rates for children living in homes where gas was used for cooking. A later analysis did not confirm this. Reasons for this are explored by using different criteria and variables to be controlled for. The results illustrate that the strength of the association between cooking fuel and illness was sensitive to the definitions of the variables and the number of subjects and city cohorts. Similar examples are presented for illness rates for four respiratory diseases: asthma, bronchitis, illness before age 2 and illness last winter. These examples of cross-sectional analyses emphasize the ambiguities of studies of possible health effects of air pollution exposures close to the present ambient air quality standards.
Evaluation and use of mosquito repellents
Authors: I. H. Gilbert
Journal: JAMA (1966)

Repellents applied to skin and clothing are of great importance in protecting human beings from mosquito attack. They are especially important when other methods of obtaining relief from annoying pests and mosquito vectors of various diseases are not feasible. Before World War II, repellent dopes gave very little protection from mosquito attack. One such dope contained oil of citronella along with gum camphor, oil of pennyroyal, pine oil, and stearic acid. Effective mosquito repellents were developed during World War II and even more efficient repellents have been developed since that time. We have not attained our ultimate goal of providing the ideal mosquito repellent, but diethyltoluamide (deet) comes the closest. This paper will be concerned primarily with the program to evaluate mosquito repellents being conducted by the Insects Affecting Man and Animals Research Laboratory at Gainesville, Fla, previously located at Orlando, Fla. I will describe the testing techniques we use
Book Review Psychoanalytical Method and the Doctrine of Freud . By Roland Dalbiez. With an introduction by E. B. Strauss, M.D. (Oxford), F.R.C.P. Translated from the French by T. F. Lindsay. 8°, cloth, Vol. 1, 415 pp. and Vol. 2, 331 pp. London: Longmans, Green and Company, 1941. $9.00.
Journal: New England Journal of Medicine (1943)
OS4.2 The long-term disease burden of meningioma patients: results on health-related quality of life, cognitive function, anxiety and depression
Authors: A H Zamanipoor Najafabadi, P B van der Meer, F W Boele, J C Reijneveld, M J B Taphoorn, M Klein, W R van Furth, L Dirven, S M Peerdeman
Journal: Neuro-Oncology (2018)

Recent systematic reviews reported that meningioma patients have an impaired health-related quality of life (HRQoL) and cognitive function up to 5 years after intervention. We aimed to assess the long-term disease burden of meningioma patients. In this multicentre cross-sectional study, intracranial meningioma patients at least 5 years (median: 9.9 years) after anti-tumour therapy were included. HRQoL was measured with the generic SF-36 (8 scales and 2 component scores) and the disease-specific EORTC QLQ-BN20 (11 scales/items), and anxiety and depression with the Hospital Anxiety and Depression Scale (HADS: ≤11/21 points is indicative for probable anxiety or depression). Six domains of cognitive function were assessed with a standardised neuropsychological test battery (z-score<-1.5 is defined as a clinically relevant deficit). Generalised linear models were used to compare meningioma patients with healthy controls, corrected for age, sex, educational level and comorbidities. One-sample t-tests were used to compare meningioma patients with normative data of newly diagnosed glioblastoma patients. Patient recruitment and data collection is still in progress. 164 meningioma patients were included (mean age 63.9 years, WHO grade I: 91.7%, surgery: 89.2%, radiotherapy: 14.6%). Compared with 110 controls, meningioma patients had worse HRQoL scores on 4/10 SF-36 scales/component scores: role limitations due to physical problems (mean difference: 11.7, p=0.03) and emotional problems (difference: 13.8, p=0.009), social functioning (difference: 9.5, p=0.016), and the mental component score (difference: 4.4, p=0.011). Meningioma patients scored similar to glioblastoma on 5/11 EORTC QLQ-BN20 scales/items: visual deficits (difference: 1.6, p=0.272), headache (difference: 2.9, p=0.324), seizure (difference: 1.6, p=0.103), drowsiness (difference: 3.7, 0.619), and hair loss (difference: 3.4, p=0.164), but better on other scales/items. Patients suffered from probable anxiety in 14.3% of cases (controls: 3.7%, p=0.015) and depression in 7.5% of cases (controls: 1.9%, p=0.011). Clinically relevant cognitive deficits were found in executive function (10.9%), verbal memory (19.4%), working memory (13.4%), attention (10.3%), information processing (25.0%) and psychomotor speed (14.4%). Almost 10 years after the last anti-tumour treatment, meningioma disease burden is still significant and in some areas comparable to newly diagnosed glioblastoma. A considerable number of patients have impaired HRQoL, suffer from cognitive deficits and report high levels of anxiety and depression.
Ethics
Authors: Edmund D. Pellegrino
Journal: JAMA (1990)

Treatment of human immunodeficiency virus infection poses some of the most difficult dilemmas in clinical medicine. As new data on natural history, treatment, and prevention appear, some new ethical questions are raised and older ones reexamined. This review focuses on the ethical impact of recent research, particularly the availability of early treatment. The most significant recent findings include the potential effectiveness of the early use of zidovudine (formerly known as azidothymidine [AZT]) in delaying the emergence of the acquired immunodeficiency syndrome (AIDS) and the use of sulfamethoxazole and aerosolized pentamidine isethionate in preventing opportunistic infections.<sup>1-3</sup>In addition, zidovudine has shown some reversing effect on AIDS dementia in children.<sup>4</sup>Dideoxyinosine seems effective in zidovudine-resistant and intolerant patients. Other more promising and more sophisticated therapies are in the offing.<sup>5</sup> None of these measures is curative, but they change the physician's approach to management dramatically. Early diagnosis, early treatment, and
Multicentric Castleman's disease with an increased serum level of macrophage colony‐stimulating factor
Authors: Muneyasu Lee, Makoto Hirokawa, Satoru Matuoka, Hitoshi Hasegawa, Hiroshi Nanjo, Takashi Matsushima, Hideo Imatani, Akira B. Miura
Journal: American Journal of Hematology (1997)

We describe a 74-year-old patient with multicentric Castleman's disease (MCD) whose serum macrophage colony-stimulating factor level was elevated. Serum levels of tumor necrosis factor-α and interleukin 6 were also elevated at presentation, and they returned to normal levels after chemotherapy. Although the total serum cholesterol level was below normal on admission, it increased after chemotherapy. These results suggest that the activation of monocytes or macrophages may be involved in certain pathological phenomena in MCD. Am. J. Hematol. 54: 321–323, 1997. © 1997 Wiley-Liss, Inc.
The sweat test for cystic fibrosis
Authors: J. B. Priest
Journal: JAMA (1979)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Unrelated Donor Umbilical Cord Blood Transplantation (UD-UCBT) for Adult Patients with High-Risk Acute Myeloid Leukemia (AML)
Authors: Jai me Sanz, Silvana Saavedra, Pau Montesinos, Ignacio Lorenzo, Javier Palau, Luis Larrea, Dolores Planelles, Guillermo Martín, Leonor Senent, Isidro Jarque, Javier de la Rubia, Federico Moscardo, Jesus Martinez, Shirley Weiss, Miguel A. Sanz, Guillermo Sanz
Journal: Blood (2008)
Multiple Aneurysm Formation in a Young Man
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Classification and treatment of tremor
Authors: M. Hallett
Journal: JAMA (1991)

<h3>SELECTED CASE</h3> A 60-YEAR-OLD right-handed man complained of tremor when writing. He had been an accountant for much of his professional life and about 5 years earlier had begun to experience tremor of his right hand only when writing. The tremor gradually worsened, making it difficult to write legibly. Legibility was improved by writing slowly but doing so reduced productivity. He consulted several physicians, who diagnosed essential tremor. Trials of propranolol hydrochloride and primidone did not help. By age 58 years, he was embarrassed by this problem and retired. The problem continued to worsen, but, because the demand for writing was minimal, he could cope. The patient consulted his physician because of difficulty in signing checks. He had no other neurological complaints. Family history of tremor was negative, and examination showed only a problem with writing. There was no tremor at rest, on maintaining a posture, or with the finger-to-nose
THE ART OF MEDICINE
Authors: J. H. T.
Journal: JAMA (1961)

THERE are men and classes of men that stand above the common herd: the soldier, the sailor, and the shepherd not unfrequently; the artist rarely; rarelier still, the clergyman; the physician almost as a rule. He is the flower (such as it is) of our civilisation." Robert Louis Stevenson prepared this appraisal of the physician when his health was perhaps at its lowest ebb, several years before he sailed to the South Seas to regain his strength. In these critical times, when physicians are under attack, strength and courage in our professional beliefs and ideals are demanded as never before. Technical progress in medical science has been phenomenal in recent decades. Has this been attained at the expense of the art of medicine? This conclusion I deny vehemently. A generation or two ago the physician had no choice but to rely largely on his skillful exploitation of the art of
Highlights
Journal: JAMA (2019)

High-Dose Vitamin D Supplementation and Bone Health 736Some adults consume high daily doses of vitamin D despite the lack of evidence for a benefi cial eff ect.Burt and colleagues randomized 311 nonosteoporotic community-dwelling healthy adults and found that treatment with vitamin D for 3 years at a dose of 4000 IU/d or 10 000 IU/d, compared with 400 IU/d, resulted in lower radial volumetric bone density.Visual Abstract jama.com Autologous Stem Cell Transplantation for Neuroblastoma 746Intensifi cation of consolidation therapy using sequential autologous transplant after induction therapy may improve outcomes in patients with high-risk neuroblastoma.Park and colleagues randomized 652 patients with high-risk neuroblastoma and found that sequential transplant, compared with single transplant, resulted in a signifi cantly higher rate of event-free survival.In an editorial, Bagatell and Irwin suggest that future trials may determine which types of patients respond well to specifi c therapies.
Take-Home Lead Exposure Among Children With Relatives Employed at a Battery Recycling Facility—Puerto Rico, 2011
Journal: JAMA (2013)

The recycling of lead has increased during the past 20 years, with more workers and their families potentially being exposed to lead from recycling facilities, including facilities that recycle lead-acid batteries. During November 2010-May 2011, four voluntary blood lead screening clinics for children of employees of a battery recycling facility in Puerto Rico were conducted. A total of 227 persons from 78 families had blood lead tests. Among 68 children aged <6 years, 11 (16%) had confirmed blood lead levels (BLLs) ≥10 µg/dL, the BLL at which CDC recommended individual intervention to reduce BLLs in 2010, and 39 (57%) children aged <6 years had venous or capillary BLLs ≥5 µg/dL, the reference value for elevated BLLs in children established by CDC in 2012. To determine whether take-home lead exposure contributed to the children's BLLs of ≥10 µg/dL, vehicle and household environmental samples were collected and analyzed. Eighty-five percent of vehicle dust samples and 49% of home dust samples exceeded the U.S. Environmental Protection Agency (EPA) level of concern of ≥40 µg/ft² (430.6 µg/m²) [corrected]. EPA began clean-up of employee homes and vehicles, focusing first on homes with children with BLLs ≥10 µg/dL. EPA also required that the company set up shower facilities, shoe washes, and clean changing areas at the battery recycling facility. Lastly, CDC assigned a case manager to provide education, environmental follow-up, and case management of all children with BLLs ≥5 µg/dL. On average, children's BLLs have decreased 9.9 µg/dL since being enrolled in case management.
Switching pills.
Journal: BMJ (1969)

basks on the lawn is likely to leave his faeces there and a child may mistake one for a liquorice all-sort.The danger from terrapins may be greater.Most are kept in aquaria indoors, and if the animals happen to be infected the water will be contaminated.No one is likely to drink aquarium water except, perhaps, dogs and other pets; but it must be changed from time to time, and the obvious place for its disposal is the kitchen sink.He is a handy man who can do this without splashing, and he would certainly con- taminate his hands.Though the danger to health from these animals is a minor one, children must be protected as far as possible from the consequences of their own foolishness.There are reasons for forbidding the importation of tortoises, but these are based on arguments for the preservation of wild life rather than on health: in parts of Yugoslavia T. hermanni has become rare.Similar arguments cannot be advanced for terrapins since they are bred for the trade.It might be possible to treat all animals with an antibiotic before sale, but the cost would be high and, from the experience of a few trials, the outcome unsatisfactory.It is probably wiser to make it generally known that these animals are a potential source of disease;
Reply
Authors: S T Pals, G J Offerhaus
Journal: Gut (1995)

published literature on the gastrointestinal effects of acupuncture, we were unable to find any controlled study showing the effect of acupuncture on ulcer healing.4There have been three reports, however, of uncontrolled studies5-7 suggesting that acupuncture may be of therapeutic benefit in peptic ulcer dis- ease and Lux et al cited one of these.It is unfortunate that Lux et al failed to recognise our own work, but more so that they did not extend our initial studies into the mechanisms participating in the inhibition of acid secretion by acupuncture.Clearly, we agree with them that further studies are needed to examine therapeutic efficacy.