tbuckley/cabot-search huggingface dataset:
LATENT AND ARTIFICIAL IMMUNIZATION AGAINST DIPHTHERIA
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Response to Letter Regarding Article by Tomic et al, “Transcriptomic and Proteomic Patterns of Systemic Inflammation in On-Pump and Off-Pump Coronary Artery Bypass Grafting”
Authors: V. Tomic, S. Rußwurm, R.A. Claus, F.M. Brunkhorst, K. Bode, F. Bloos, K. Reinhart, M. Bauer, E. Möller, M. Blaess, H.-P. Deigner, M. Bruegel, J. Thiery, J. Wippermann, T. Wahlers
Journal: Circulation (2006)

Coronary Artery Bypass Grafting"We thank Dr O'Dwyer and colleagues for their letter in which they raise concerns regarding interpretation of the discordance between protein and cytokine mRNA levels in patients undergoing coronary bypass surgery and regarding the isolation of RNA from whole blood by the PaxGene methodology. 1 We would like to use this opportunity to clarify that RNA was isolated for all experiments by the PaxGene whole blood method, including the positive control, ie, ex vivo endotoxinspiked whole blood cultures.We agree that the legend to Figure 3 in our original article is somewhat misleading because we refer to "total RNA isolated from [peripheral blood mononuclear cells]," although as is increasingly acknowledged, RNA might also be derived from sources other than peripheral blood mononuclear cells exclusively. 2,3reparation of RNA for microarrays is indeed a critical preanalytical step, as differences attributable to the mode of RNA isolation might even outweigh changes in transcript expression caused by a biological insult, as shown by the Glue Grant consortium. 4 Nevertheless, although there are changes that clearly depend on the method of RNA preparation, the question remains which of the established methods may best reflect the cell response in vivo and yield the de facto transcription pattern.Although PaxGene offers a number of technical advantages, increased noise and reduced responsiveness reflect possible limitations.However, immediate-early gene response during and after isolation are likely to result in false-positive results for all protocols that involve cell enrichment.Furthermore, induction of genes on density gradient centrifugation or magnetic sorting, for example, might depend on the functional state of leukocytes, and thus would be different for naïve as opposed to primed leukocytes.Therefore, RNA isolation for reliable transcriptional profiling will likely be plagued by the lack of an accepted methodology for the near future.On the basis of our recent results in stabilized whole blood, it will be a challenge to investigate gene expression in subclasses of leukocytes and in platelets from patients undergoing coronary bypass surgery.
FAMILY EXEMPTION FROM CHOLERA SECURED BY SANITARY MEASURES.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Software
Authors: J. MICHAEL DEAN
Journal: Annals of Internal Medicine (1985)

Article1 November 1985SoftwareJ. MICHAEL DEAN, M.D.J. MICHAEL DEAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-103-5-817 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCriticare ICU Package, 1985Type: Hemodynamic and drug calculations program.Computer: IBM-PC, XT, or compatible, 128K RAM, two double-sided disk drives or hard disk drive with one double-sided disk drive, monochrome or RGB monitor, 80-column printer, DOS 2.0 or greater. Tested with IBM-PC and hard disk.Format: Two 5¼-inch double-sided double-density floppy disks.Documentation: Loose-leaf binder with 69 typewritten pages, no index, plastic sleeves provided for disks.Publisher: Criticare Data Corporation, P.O. Box 292426, Kettering, Ohio, 45429. (513) 298-8535.Price: $595.00This set of programs includes hemodynamic analysis, aminoglycoside pharmacokinetics, intravenous drug calculations, coronary artery risk analysis, physiologic clearance calculations,... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEight-membered Rings with Two Heteroatoms 1,2Volume 9 References 1 November 1985Volume 103, Issue 5Page: 817-818KeywordsComputersCoronary arteriesDrug pricesDrugsHemodynamicsIntensive care unitsPharmacokinetics ePublished: 1 December 2008 Issue Published: 1 November 1985 PDF downloadLoading ...
Cigarette smoking decreases cerebral blood flow suggesting increased risk for stroke
Authors: R. L. Rogers
Journal: JAMA (1983)

Effects of chronic cigarette smoking on cerebral blood flow were investigated by measuring gray matter blood flow (Fg) using xenon 133 inhalation among 192 volunteers without cerebrovascular symptoms. There were 108 normal, healthy volunteers; 84 had risk factors for stroke (hypertension, hyperlipidemia, diabetes mellitus, and/or heart disease). Of both risk and nonrisk groups, 75 were habitual smokers (0.5 to 3.5 packs per day for 25 years). Comparisons of mean Fg values for both hemispheres showed significant reductions related to tobacco consumption and risk factors for stroke. Multiple-regression equations using smoking, age, risk, and alcohol consumption indicated a combined R2 value of 0.22. Smoking seems to be a potent risk factor decreasing cerebral blood flow probably by enhancing cerebral arteriosclerosis. Chronic cigarette smoking in persons with other risk factors further reduced Fg values in an additive manner when compared with subjects who had corresponding risk factors who did not smoke. (<i>JAMA</i>1983;250:2796-2800)
Manuscripts Approved For JNCI, September-October 1971
Journal: JNCI Journal of the National Cancer Institute (1971)

Manuscripts Approved For JNCI, September-October 1971 Get access JNCI: Journal of the National Cancer Institute, Volume 47, Issue 5, November 1971, Pages 1165–1167, https://doi.org/10.1093/jnci/47.5.1165-b Published: 01 November 1971
Sports for Everyone
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Guidelines for the Development of a National AIDS Prevention and Control Programme. Volume 1. WHO AIDS Series Guidelines on Sterilization and Disinfection Methods Effective against Human Immunodeficiency Virus (HIV). Volume 2. WHO AIDS Series Guidelines for Nursing Management of People Infected with Human Immunodeficiency Virus (HIV). Volume 3. WHO AIDS Series Monitoring of National AIDS Prevention and Control Programmes. Volume 4. WHO AIDS Series Guide to Planning Health Promotion for AIDS …
Journal: Annals of Internal Medicine (1990)
Grundriss der Heilpädagogik.
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Internal derangement of the knee
Authors: O. E. Aufranc
Journal: JAMA (1965)

Dr. Kirby vonKessler: A 21-year-old man was in an accident while riding a motor bicycle. He entered an emergency ward at a nearby hospital, with multiple abrasions about his left knee. The knee was diffusely swollen and tender. X-ray films were interpreted as normal. After the abrasions were thoroughly cleansed and wrapped in sterile bandages, the patient was discharged using crutches. A loose body measuring approximately 2 cm in diameter was noted in the anterior portion of the joint space of the knee when a radiologist interpreted the x-ray films 72 hours later. The patient was then referred to the Massachusetts General Hospital. Because of this lapse of time, the abrasions were grossly infected. The patient could flex the knee to 70°, but was unable to extend it beyond 45° from full extension. A positive "anterior drawer sign" was present. Because the knee could not be fully extended, the stability
In vivo expression of IL-4, IL-5, IL-13 and IFN-γ mRNAs in peripheral blood mononuclear cells and effect of cyclosporin A in a patient with Kimura's disease
Authors: K. KATAGIRI, S. ITAMI, Y. HATANO, T. YAMAGUCHI, S. TAKAYASU
Journal: British Journal of Dermatology (1997)
Cartilage of the hip joint. Topographical variation of glycosaminoglycan content in normal and fibrillated tissue.
Authors: A Maroudas, H Evans, L Almeida
Journal: Annals of the Rheumatic Diseases (1973)

In recent years several authors have studied patterns of degradation of articular cartilage with special reference to different areas on a given joint (e.g.Goodfellow and Bullough, 1967; Byers, Con- tepomi, and Farkas
Hypokalemia after resuscitation from out-of-hospital ventricular fibrillation
Authors: R. G. Thompson
Journal: JAMA (1982)

We studied serum electrolyte levels, blood gas values, and diuretic history in 115 patients immediately after resuscitation from out-of-hospital ventricular fibrillation. Comparisons were made with 84 patients admitted for acute myocardial infarction and with 88 ambulatory patients with coronary heart disease. Admission serum potassium values of 3.60 mEq/L or lower were found in 56 (49%) of the resuscitated patients, compared with 16 (19%) and eight (9%) of the comparison groups, respectively. In the resuscitated patients, the mean serum potassium level was 3.70±0.72 (SD) mEq/L, compared with 4.09 ±0.66 and 4.17 ±0.35 mEq/L in the respective comparison groups. Reduced serum potassium concentration was not related to simple extracellular alkalosis. However, the absence of a causative relationship to diuretic use suggested that it occurred during cardiac arrest and resuscitation. Rapid correction of extracellular acidosis by bicarbonate therapy and ventilation may have produced a shift of extracellular potassium into the intracellular compartment even in the absence of extracellular alkalosis. (<i>JAMA</i>1982;248:2860-2863)
Brain Heterotopia
Authors: Homayoun Modarresifar, Linh Ho
Journal: Clinical Nuclear Medicine (2009)

We present a case with intractable partial complex seizures in a 14-year-old girl who was found to have brain heterotopia on MRI and PET-CT. The patient presented with intractable partial complex seizures and a normal electroencephalogram. Her brain magnetic resonance imaging showed heterotopic gray matter lining the ventricular margin of the right occipital horn. Subsequent PET-CT demonstrated moderate tracer localization in the heterotopic gray matter surrounding the ventricular margin of the right occipital horn. Heterotopia may demonstrate normal or increased FDG uptake on PET, therefore its appearance may be deceiving when other pathologies are being considered.
Initial phase I study of XR5944, a novel DNA and RNA targeting agent
Authors: M. Cooper, E. Rankin, D. Bissett, M. Nicolson, H. Thomas, J. Steiner, G. Mellows, G. Allen, D. Norris, J. Waterfall
Journal: Journal of Clinical Oncology (2004)

2100 Background: XR5994 (MLN944) is a novel DNA/RNA targeting agent with a mechanism of action distinct from that of currently available cytotoxic chemotherapeutic agents. Although this compound was originally developed as an inhibitor of topoisomerases I and II, studies of its cell cycle effects and effects in topoisomerase-deficient yeast show that topoisomerase interactions do not explain its potent and broad spectrum of activity. More recent studies have shown that XR5994 binds to the major groove of DNA and inhibits RNA synthesis with an EC50 = 3 nM. Because of XR5944's unique mechanism of action and activity across several human tumor cell lines and xenograft models, we have initiated a phase I clinical trial of this compound in patients with advanced, treatment-refractory solid tumors. Methods: XR5944 is given as a single 30 minute intravenous infusion repeated once every 21 or 28 days. The starting dose selected for this study was 3.6 mg/m2, which is a NOAEL (no observable adverse effect level) in the most sensitive species (the Beagle dog) and is just below one-tenth of the MTD in the rat. Preclinical toxicologic evaluation of XR5944 in dogs and rats suggests dose-limiting toxicities of reversible myelosuppression and gastrointestinal epithelial damage. Dose escalation follows a modified Fibonnaci search scheme, with 2 patients enrolled at each dose level until CTC grade 2 or greater drug-related toxicity is observed. After the occurrence of such toxicity cohorts of 3–6 patients will be evaluated at each dose level. Results: To date a total of 9 patients have been enrolled in this study, 2 patients each at dose levels of 3.6, 7.2, 14, and 24 mg/m2, and 1 of 2 planned patients at the 36 mg/m2 dose level. No drug-related toxicity has yet been observed in any patient. The pharmacokinetics of XR5944 are linear over the dose range of 3.6 to 24 mg/m2, with mean (SD) CL = 29.6 (6.4) L/hour/m2, Vss = 937 (382) L/m2, and t1/2 = 61.8 (13.4) hours. The average AUC0-t and Cmax at a dose of 24 mg/m2 are 1060 ng-hr/mL and 1090 ng/mL, respectively, which exceed those observed in the dog and rat at their respective MTDs. Conclusions: Dose escalation continues in this study, with updated results to be reported at the time of presentation. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Millennium Pharmaceuticals Millennium Pharmaceuticals Millennium Pharmaceuticals
LEIOMYOMA CUTIS.
Authors: L. H. JANSEN, F. M. L. DRIESSEN
Journal: British Journal of Dermatology (1958)

Journal Article LEIOMYOMA CUTIS. Get access L. H. JANSEN, M.D. and, L. H. JANSEN, M.D. and The Dermatological Department, The State University, Utrecht Search for other works by this author on: Oxford Academic Google Scholar F. M. L. DRIESSEN, M.D. F. M. L. DRIESSEN, M.D. The Dermatological Department, The State University, Utrecht Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 70, Issue 12, 1 December 1958, Pages 446–451, https://doi.org/10.1111/j.1365-2133.1958.tb13284.x Published: 01 December 1958
Time Course of Functional Recovery of Stunned and Hibernating Segments After Surgical Revascularization
Authors: Jeroen J. Bax, Frans C. Visser, Don Poldermans, Abdou Elhendy, Jan H. Cornel, Eric Boersma, Arthur van Lingen, Paolo M. Fioretti, Cees A. Visser
Journal: Circulation (2001)

Background Recovery of function is possible in patients with ischemic cardiomyopathy when left ventricular dysfunction is caused by stunning or hibernation. It is plausible that recovery of function after revascularization may take a longer time in hibernating myocardium compared with stunned myocardium. Accordingly, the time courses of functional recovery in hibernating and stunned myocardium were compared. Methods and Results Patients (n=26) with ischemic cardiomyopathy undergoing surgical revascularization were studied; regional perfusion (resting 201 Tl single-photon emission CT), glucose utilization ( 18 F-2-deoxyglucose single-photon emission CT), and contractile function (2D echocardiography) were assessed before revascularization. Dysfunctional segments with normal perfusion/glucose utilization were considered to be stunned, and dysfunctional segments with reduced perfusion/preserved glucose utilization were considered to be hibernating. Contractile function was reevaluated 3 months (early) and 14 months (late) after revascularization. Of the 266 dysfunctional segments, 57 (22%) were stunned, 62 (23%) were hibernating, and 147 (55%) were scar tissue. In stunned myocardium, contractile function improved significantly at 3 months, without further improvement at 14 months; 61% of the stunned segments improved at 3 months, and 9% improved at 14 months. In hibernating myocardium, contractile function improved at 3 months, with a further improvement at 14 months; 31% of the hibernating segments improved at 3 months, and 61% showed (additional) recovery at 14 months. Conclusions Stunned myocardium is likely to demonstrate early recovery of function, whereas hibernating myocardium may take a longer time to (fully) recover in function after revascularization.
MODIFICATION OF FORDYCE NEEDLE USED FOR THE COLLECTION OF BLOOD AND FOR INTRAVENOUS THERAPY
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
GELATIN AS A FOOD AND THERAPEUTIC AGENT.MAKING VACCINATION FASHIONABLE.
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal