tbuckley/cabot-search huggingface dataset:
It's Hardly Sport, but Parachuting Fire Fighters May Benefit From What Sports Medicine Has Learned
Authors: Virginia S. Cowart
Journal: JAMA (1988)

WILDFIRES around Yellowstone National Park and elsewhere in the Northwest have kept forest fire fighters in the headlines for weeks. Among persons in this unique line of work, smokejumpers—the commandos of fire fighting—do the same dangerous work as all fire fighters, but add to the risks by going to work in a parachute. Efforts to reduce these risks have become the focus of some sports medicine physicians. The US Forest Service created smokejumper units some years ago in the hope of reducing destruction from out-of-control forest fires by having a mobile force that could drop into a fire zone and be working on containment long before conventional fire fighters could reach the area. That philosophy once again was tested with the summer and fall already having been preceded by a lengthy drought in many areas (<i>Wall Street Journal</i>1988;69:1, July 29). And, there is the recent memory of the 1987
A Practice-Related Educational Program
Authors: F. L. Bowler
Journal: JAMA (1977)

A Practice-Related Educational Program has been developed to help the physician in primary practice meet the mounting pressures for continuing medical education. Based on analysis of his practice, the physician tests himself to identify areas of potential improvement. Learning resources appropriate to his educational needs are then made available to him at his home base. A follow-up test determines if the person's learning has been effective, and where further emphasis may be placed. (<i>JAMA</i>237:1346-1349, 1977)
<i>Occupation Therapy: A Manual for Nurses</i>. By William R. Dunton, Jr., B. S., M. A., M. D., Assistant Physician at Sheppard and Enoch Pratt Hospital, Towson, Md. ; Instructor in Psychiatry, Johns Hopkins University. 43 illustrations. (<i>Philadelphia and London: W. B. Saunders Company, 1915</i>.)
Authors: C. F. H.
Journal: American Journal of Psychiatry (1915)

Oct Mrs. Stephens, for the gout, etc., and some useful directions for gardening and husbandry, and likewise for travelers, in regard to the management of a horse on a j ourney, etc. ; with many curious secrets in art and nature.84 pp.52#{176}.London, W
Alectinib versus crizotinib in treatment-naive advanced <i>ALK</i>-positive non-small cell lung cancer (NSCLC): Primary results of the global phase III ALEX study.
Authors: Alice Tsang Shaw, Solange Peters, Tony Mok, Shirish M. Gadgeel, Jin Seok Ahn, Sai-Hong Ignatius Ou, Maurice Perol, Rafal Dziadziuszko, Dong-Wan Kim, Rafael Rosell, Ali Hassan Zeaiter, Ting Liu, Sophie Golding, Bogdana Balas, Johannes Noé, Peter N. Morcos, D. Ross Camidge
Journal: Journal of Clinical Oncology (2017)

The full, final text of this abstract will be available at abstracts.asco.org at 7:30 AM (EDT) on Monday, June 5, 2017, and in the Annual Meeting Proceedings online supplement to the June 20, 2017, issue of the Journal of Clinical Oncology. On site at the Meeting, this abstract will be printed in the Monday edition of ASCO Daily News.
Abstract 686: Quantitative analysis of the role of homologous recombination in response to radiotherapy for prostate cancer
Authors: Mengdi Qian, Alexandru Almasan, Evren Gürkan-Çavusoglu
Journal: Cancer Research (2019)

Abstract The purpose of this study is to computationally analyze how the interaction between androgen receptor (AR) and homologous recombination (HR) affects the treatment outcome for ionizing radiation (IR) combined with androgen deprivation therapy (ADT) for prostate cancer (PCa). Combination treatment with radiation and ADT is currently a standard treatment for PCa. The effectiveness of radiation treatment alone depends on the cells’ capacity to repair the damage that is mostly in the form of double-strand breaks (DSBs). Two major pathways that repair DSBs are non-homologous end joining (NHEJ) and HR. The experimental data in the literature show that AR promotes both NHEJ and HR following IR, and inhibition of AR by ADT impairs both of these pathways in PCa cells leading to either increased radiosensitivity or sensitization to PARP inhibitors. In our previous work, we developed mathematical models of the NHEJ pathway and in this current work we have developed such models for HR to comprehensively analyze the response of PCa cells to IR combined with ADT. We have modeled HR using a series of ordinary differential equations. The parameters that needed to be estimated are the kinetic rate constants, and we have used least square estimation to obtain these model parameters. The data sets used in the parameter estimation were obtained from the literature and they were from both in vitro experiments as well as clinical data from PCa patients. The experimental data show that AR influences the DNA end resection that is required for proficient HR and we have computationally included this effect in the kinetics of the models. We have developed models for IR treatment alone or in combination with ADT. We have carried out sensitivity analysis and identifiability tests on all the parameters from both models in order to determine the parameters that are reliably estimated. The outputs from both NHEJ and HR models show that the suppression of AR activity through ADT has the potential to enhance the IR treatment outcomes for PCa patients. The impairment of HR by ADT also opens up an avenue for achieving synthetic lethality using PARP inhibitors as shown in the literature; in the future we are planning to extend our modeling efforts to include the effect of PARP inhibitors on the treatment outcome. Citation Format: Mengdi Qian, Alexandru Almasan, Evren Gürkan-Çavusoglu. Quantitative analysis of the role of homologous recombination in response to radiotherapy for prostate cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 686.
Chronic Pancreatitis
Authors: WILLIAMSON B. STRUM
Journal: Annals of Internal Medicine (1971)

The temperate person who occasionally overindulges in alcohol will not ordinarily develop acute pancreatitis. Acute pancreatitis in the alcoholic develops only after the changes of chronic pancreatitis have developed, and relapsing attacks of acute pancreatitis may stop or may no longer occur if the patient stops drinking, even though progressive destruction of the pancreas continues. Other forms of pancreatitis which the clinician may encounter, and should always consider, are described.
Congress of Physicians.
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abdominal Aortic Aneurysm
Authors: C B Ernst
Journal: New England Journal of Medicine (1993)

Modern treatment of abdominal aortic aneurysms began in Paris on March 29, 1951, when Dubost performed the first successful aortic resection for aneurysm1. The following year American vascular surgeons duplicated Dubost's feat and established aortic reconstruction as the treatment of choice. Today, few dispute that all aneurysms of a predefined size should be repaired unless strong contraindications are present.This review addresses the contemporary knowledge and management of infrarenal abdominal aortic aneurysms. It does not discuss infected aneurysms, thoracoabdominal and pararenal aneurysms, anastomotic aneurysms, or aortic dissections. An aneurysm is defined as a focal dilation of the aorta involving . . .
Outcomes for Patients With Stroke in Managed Care vs Fee-for-Service
Authors: Clifford F. Feiner
Journal: JAMA (1997)

<h3>To the Editor.</h3> —In their study examining the outcomes of stroke patients in Medicare fee-for-service (FFS) and managed care systems, Dr Retchin and colleagues neglected to mention the potential of skilled nursing facilities in the rehabilitation of stroke patients. Many nursing homes provide excellent rehabilitation with a multidisciplinary team approach, which allows patients who are frail after stroke and have multiple comorbidities to improve their functional status at a less intense rate than would be expected on an acute care unit. Future research needs to focus on how functional improvement and quality of life are affected by rehabilitation therapy, regardless of setting.
REPORT AND COMMENTARY: The Carcinogenic Hazard of Radiation to the Breasts
Journal: CA A Cancer Journal for Clinicians (1970)

CA: A Cancer Journal for CliniciansVolume 20, Issue 1 p. 24-31 Report and CommentaryFree Access The carcinogenic hazard of radiation to the breasts First published: January/February 1970 https://doi.org/10.3322/canjclin.20.1.24AboutSectionsPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat References 1 Cronkite, E. P.: More hazards of radiation. New England J. Med. 279: 714– 715, 1968. CrossrefGoogle Scholar 2 Wanebo, C. K., et al.: Breast cancer after exposure to the atomic bombings of Hiroshima and Nagasaki. New England J. Med. 279: 667– 671, 1968. CrossrefCASPubMedWeb of Science®Google Scholar 3 Myrden, J. A., and Hiltz, J. E.: Breast cancer following multiple fluoroscopies during artificial pneumothorax treatment of pulmonary tuberculosis. Canad. M.A.J. 100: 1032– 1034, 1969. CASPubMedWeb of Science®Google Scholar 4 “When fluoroscopy causes cancer.” Medical World News. August 8, 1969. P. 14a. Google Scholar 5 Stone, R. S.: Common sense in radiation protection applied to clinical practice. Am. J. Roentgenol. 78: 993– 999, 1957. PubMedWeb of Science®Google Scholar 6 Furth, J., and Furth, O. B.: Neoplastic diseases produced in mice by general irradiation with x-rays; incidence and types of neoplasms. Am. J. Cancer 28: 54– 65, 1936. Google Scholar 7 Bond, V. P., et al.: Studies on rediation-induced mammary gland neoplasia in the rat. III. Relation of neoplastic response to dose of total-body radiation. Radiation Res. 12: 276– 285, 1960. CrossrefCASPubMedWeb of Science®Google Scholar 8 Shellabarger, C. J., and Schmidt, R. W.: Mammary neoplasia after in vitro x-irradiation of mammary tissue. Nature (London) 218: 192– 193, 1968. CrossrefCASPubMedWeb of Science®Google Scholar 9 MacKenzie, I.: Breast cancer following multiple fluoroscopies. Brit. J. Cancer 19: 1– 8, 1965. CrossrefPubMedWeb of Science®Google Scholar 10 Mettler, F. A., Jr., et al.: Breast neoplasms in women treated with x-ray for post-partum mastitis: preliminary report. Submitted for publication. Atomic Bomb Casualty Commission Google Scholar 11 Stone, R. S.: Common sense in radiation protection applied to clinical practice. Am. J. Roentgenol. 78: 993– 999, 1957. PubMedWeb of Science®Google Scholar 12 Stein, J. J.: The carcinogenic hazards of ionizing radiation in diagnostic and therapeutic radiology. Ca-A Cancer Journal for Clinicians 17: 278– 287, 1967. Wiley Online LibraryCASPubMedGoogle Scholar Volume20, Issue1January/February 1970Pages 24-31 ReferencesRelatedInformation
DEATHS OF PHYSICIANS IN 1920
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
"DESTRUCTION OF EPINEPHRINE IN THE BODY"
Journal: JAMA (1929)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Neuropathy Following Exposure to a Dimethylamine Salt of (2,4-Dichlorophenoxy) Acetic Acid
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical evaluation of cryoprecipitated factor 8
Authors: L. R. Simson
Journal: JAMA (1967)

Although there is increasing reason to believe that the pathogenesis of classical hemophilia involves much more than deficiency of a plasma clotting factor,<sup>1</sup>treatment of bleeding episodes remains firmly based upon the infusion of factor VIII.<sup>2</sup>The rationale of plasma transfusion therapy has been well defined<sup>3</sup>and assay procedures<sup>4,5</sup>have been developed which permit an accurate diagnosis of hemophilia (hemophilia A), and, in addition, enable quantitative assessment of therapy. Nevertheless, treatment of this disorder still is beset with difficulties. Large and frequent transfusions of fresh, freshfrozen, or reconstituted freeze-dried plasma are required to achieve and maintain hemostatic levels of factor VIII. Daily transfusions approximating one third of the patient's circulating plasma volume are required over a period of weeks to control hemorrhage following surgical procedures. Such massive plasma transfusions present the concomitant risk of circulatory overload. Moreover, prolonged plasma therapy limits the mobility of the patient
THE INEFFICIENT TREATMENT OF ANEMIA
Authors: P. C.
Journal: Annals of Internal Medicine (1940)

Editorial1 March 1940THE INEFFICIENT TREATMENT OF ANEMIAP. C.P. C.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-13-9-1753 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe studies of the past fifteen years have added greatly to our knowledge of the various types of anemia and have provided a sound basis for their intelligent and efficient treatment. As yet, however, there has not been a corresponding improvement in the methods of treatment generally employed.Most cases of anemia can be placed in one of three large groups, depending upon the relative size and hemoglobin concentration of the red cells. The hypochromic microcytic group, with small pale cells, is associated with iron deficiency. This anemia practically always responds to the administration of adequate doses of simple inorganic... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1940Volume 13, Issue 9Page: 1753-1755KeywordsAnemiaAttentionCellsHemoglobinIron deficiency Issue Published: 1 March 1940 PDF downloadLoading ...
Chemotherapy alone versus surgery followed by chemotherapy for stage I/IIE large‐cell lymphoma of the stomach
Authors: Han‐Ting Liu, Chiun Hsu, Chi‐Long Chen, I‐Ping Chiang, Li‐Tzong Chen, Yao‐Chang Chen, Ann‐Lii Cheng
Journal: American Journal of Hematology (2000)

The optimal treatment of localized large-cell lymphoma of the stomach remains controversial. In particular, the role of surgical resection of the primary tumor needs to be clearly defined. We have reviewed all patients with a diagnosis of gastric lymphoma and treated in our institutions between 1988 and 1998. Patients fulfilling the following criteria were included in this study: (1) histologically proven large-cell lymphoma of the stomach; (2) adequate pathological materials and complete clinical information for analysis; (3) clinical stage I/II disease according to the Musshoff modification of Ann Arbor system; and (4) received primary chemotherapy alone with anthracycline- or anthracenedione-containing regimens (group A) or curative surgery followed by adjuvant chemotherapy (group B). There were 38 and 21 patients in group A and group B, respectively. All pertinent clinicopathologic features were similar between the two groups of patients, except that patients of group A had significantly more stage II-2 disease (P = 0.004). Of group A, among 36 patients who could be evaluated for response to chemotherapy, there were 29 complete and 1 partial responses, with an overall response rate of 83.3% (95% CI, 71.1–95.5%). The projected 5-year relapse-free survival (RFS) and overall survival (OS) were 86.0% (95% CI, 73.3–98.7%) and 72.6% (95% CI, 57.0–88.2%), respectively. On the other hand, the projected 5-year RFS and OS of group B were 77.9% (95% CI, 58.0–97.8%) and 77.8% (95% CI, 57.9–97.7%), respectively, not significantly different from that of group A. Our data suggest that systemic chemotherapy alone may be a reasonable alternative treatment for stage I/II large-cell lymphoma of the stomach. Resection of the primary tumor before systemic chemotherapy does not appear to improve the cure rate of this group of patients. Am. J. Hematol. 64:175–179, 2000. © 2000 Wiley-Liss, Inc.
Abstract 3110: Microglia-stimulation of glioma cell invasion is dependent on EGFR and CSF1R signaling
Authors: Salvatore J. Coniglio, Kostantin Dobrenis, Richard Stanley, Marc H. Symons, Jeffrey E. Segall
Journal: Cancer Research (2011)

Abstract Glioblastoma multiforme is a deadly cancer whose current treatment options are limited. The ability of glioblastoma tumor cells to infiltrate the surrounding brain parenchyma makes complete removal of these tumors nearly impossible. We investigated how microglia, the resident macrophages of the brain, stimulate glioblastoma cell invasion. We examined the ability of normal microglia from C57Bl/6J mice to stimulate GL261 glioblastoma cell invasion in vitro. The two cell populations were differentially labeled with cell tracker dyes and invasion was quantified by confocal imaging. The effect of inhibiting EGFR and CSF1R (c-fms) on microglia-stimulated glioblastoma invasion using pharmacological agents was tested. We also determined the level of EGF and CSF1 ligand expression by glioblastoma and microglial cells using ELISA, western blotting, and immunofluorescence. We found that microglia stimulate the invasion of GL261 glioblastoma cells by approximately 8 fold in an in vitro invasion assay. Pharmacological inhibition of EGFR strongly inhibited microglia-stimulated invasion. Furthermore, using a pharmacological CSF-1R kinase domain inhibitor, we showed that CSF-1R signaling is also required for microglial enhancement of glioblastoma invasion. GL261 cells were found to constitutively secrete CSF-1, the levels of which are unaffected by EGF stimulation, EGFR inhibition or coculture with microglia. We also demonstrated that microglia express EGF which is largely associated with the plasma membrane. These data indicate that during invasion, glioblastoma and microglia cells signal to each other using EGF and CSF-1. The results of this study indicate the possibility of inhibiting glioblastoma invasion by targeting glioblastoma-associated microglia. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3110. doi:10.1158/1538-7445.AM2011-3110