tbuckley/cabot-search huggingface dataset:
Antiretroviral Treatment of Adult HIV Infection
Authors: Melanie A. Thompson, Judith A. Aberg, Pedro Cahn, Julio S. G. Montaner, Giuliano Rizzardini, Amalio Telenti, José M. Gatell, Huldrych F. Günthard, Scott M. Hammer, Martin S. Hirsch, Donna M. Jacobsen, Peter Reiss, Douglas D. Richman, Paul A. Volberding, Patrick Yeni, Robert T. Schooley
Journal: JAMA (2010)

<h3>Context</h3>Recent data regarding the consequences of untreated human immunodeficiency virus (HIV) infection and the expansion of treatment choices for antiretroviral-naive and antiretroviral-experienced patients warrant an update of the International AIDS Society–USA guidelines for the use of antiretroviral therapy in adults with HIV infection.<h3>Objectives</h3>To provide updated recommendations for management of HIV-infected adults, using antiretroviral drugs and laboratory monitoring tools available in the international, developed-world setting. This report provides guidelines for when to initiate antiretroviral therapy, selection of appropriate initial regimens, patient monitoring, when to change therapy, and what regimens to use when changing.<h3>Data Sources and Study Selection</h3>A panel with expertise in HIV research and clinical care reviewed relevant data published or presented at selected scientific conferences since the last panel report through April 2010. Data were identified through a PubMed search, review of scientific conference abstracts, and requests to antiretroviral drug manufacturers for updated clinical trials and adverse event data.<h3>Data Extraction and Synthesis</h3>New evidence was reviewed by the panel. Recommendations were drafted by section writing committees and reviewed and edited by the entire panel. The quality and strength of the evidence were rated and recommendations were made by full panel consensus.<h3>Conclusions</h3>Patient readiness for treatment should be confirmed before initiation of antiretroviral treatment. Therapy is recommended for asymptomatic patients with a CD4 cell count ≤500/μL, for all symptomatic patients, and those with specific conditions and comorbidities. Therapy should be considered for asymptomatic patients with CD4 cell count &gt;500/μL. Components of the initial and subsequent regimens must be individualized, particularly in the context of concurrent conditions. Patients receiving antiretroviral treatment should be monitored regularly; treatment failure should be detected and managed early, with the goal of therapy, even in heavily pretreated patients, being HIV-1 RNA suppression below commercially available assay quantification limits.
Validation of the diagnosis of mesothelioma and BAP1 protein expression in a cohort of asbestos textile workers from Northern Italy
Authors: P. Boffetta, L. Righi, C. Ciocan, C. Pelucchi, C. La Vecchia, C. Romano, M. Papotti, E. Pira
Journal: Annals of Oncology (2019)

Ann Oncol 2018; 29(2): 484–489 (doi: 10.1093/annonc/mdx762) The section ‘Disclosure’ has been corrected to read: “PB, CLV, CR and EP acted as experts in litigation related to asbestos and mesothelioma, outside the submitted work. All other authors have declared no conflicts of interest.” Validation of the diagnosis of mesothelioma and BAP1 protein expression in a cohort of asbestos textile workers from Northern ItalyAnnals of OncologyVol. 29Issue 2PreviewDiagnosis of mesothelioma based on death certificate is subject to misclassification, which may bias the results of epidemiology studies. A high proportion of mesothelioma harbor mutations in the BRCA1-associated protein 1 (BAP1) gene. Full-Text PDF Open Archive
Overexpression of laminin and collagen ?1(IV) mRNA in non tumoral areas of livers from patients with metastasis or hepatocellular carcinoma . 1Unit� de Recherches H�patologiques, INSERM U-49, 2Laboratoire d'Anatomie Pathologique B, 3Clinique Chirurgicale B, Facult� de M�decine, CHRU Ponthcaillou, F-35033 Rennes and 4Laboratory of Developmental Biology, NIDR, Bethesda MD 20892
Journal: Hepatology (1995)
Pediatric liver transplantation for langerhans' cell histiocytosis
Authors: P ZANDI
Journal: Hepatology (1995)

Langerhans' cell histiocytosis (LCH) represents 15% to 20% of sclerosing cholangitis (SC) in children. In LCH-associated SC, a very poor response to chemotherapy has been reported, and spontaneous prognosis is very bad. Few cases of orthotopic liver transplantation (OLT) for LCH have been reported and little is known about the risk of recurrence and the effect of immunosuppression after OLT. Since 1986, five children (mean age ± SD, 12.6 ± 3.6 years) underwent OLT for SC complicating LCH. All patients presented with growth retardation, and severe liver disease including repeated episodes of variceal bleeding (n = 5), liver insufficiency (n = 4), jaundice (n = 5), and ascitis (n = 4). Four patients presented with previous abdominal surgery (mesocaval shunt in two and explorative laparotomy in two). OLT was performed using a whole (n = 2) or a reduced liver graft (n = 3). Pathological examination of the recipient liver showed biliary cirrhosis in all cases. Three patients are alive and well 9 to 88 months after OLT. None presented with recurrence of LCH or SC within the liver graft or in other organs. General condition (including growth and puberty) improved dramatically in the three surviving patients. Absence of recurrence after up to 7 years of follow-up after liver transplantation in our patients, as well as in all other reported cases, is encouraging and shows that OLT may be indicated in end-stage liver disease complicating LCH. Furthermore, cyclosporine may be beneficial for preventing recurrence of LCH, in which autoimmunologic mechanisms have been advocated. (Hepatology 1995;21:129–133).
ARTERIAL HYPERTENSION ASSOCIATED WITH ENDOCRINE DYSCRASIA
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Instructions For Authors
Journal: JAMA (1975)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Influence of Chemical and Physical Forms of Ambient Air Acids on Airway Doses
Authors: Timothy V. Larson
Journal: Environmental Health Perspectives (1989)

The effects of ambient relative humidity and particle size on acid deposition within the airways have been examined with a computer model. For H2SO4 particles initially at 90% relative humidity in ambient air that are inhaled via the nose or mouth, there is significant deposition of acid in the airways even in the presence of typical values of respiratory NH3. When these same particles are found in a fog at 100.015% relative humidity, there is significant deposition of acid in the nasal region during nose breathing but insignificant deposition to the deep lung for either nose or mouth breathing. The factors governing the partitioning of labile acid gases in the gas and liquid phases prior to inhalation are also discussed.
Chest X-Ray Survey of Large Urban Fire Department
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Wrong Number
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Impact of omission of completion axillary lymph node dissection (cALND) or axillary radiotherapy (ax RT) in breast cancer patients with micrometastases (pN1mi) or isolated tumor cells (pN0[i+]) in the sentinel lymph node (SN): Results from the MIRROR study
Authors: V. C. Tjan-Heijnen, M. J. Pepels, M. de Boer, G. F. Borm, J. A. van Dijck, C. H. van Deurzen, E. M. Adang, M. B. Menke-Pluymers, P. J. van Diest, P. Bult
Journal: Journal of Clinical Oncology (2009)

CRA506 Background: The Dutch MIRROR study is the largest cohort study on pN1mi and pN0(i+) in the SN era with long-term follow-up, central pathology review (6th AJCC-classification), and separate analyses on the use of adjuvant systemic therapy (AST). In patients not receiving AST, pN1mi and pN0(i+) as final N-stage were shown to be independent prognosticators for disease-free survival (SABCS 2008, #23, oral). As a substantial number of patients in the MIRROR study did not undergo cALND or ax RT, we questioned whether this policy was safe in patients with pN1mi(sn) or pN0(i+)(sn). Methods: Patients operated for breast cancer in all Dutch hospitals in the years 1998–2005, having favorable primary tumor characteristics, and having undergone an SN biopsy without macrometastases as final N-stage were included. For this present research question, patients were categorized by their SN-stage. Median follow-up was 4.7 years. The Kaplan-Meier method was used to estimate 5-year axillary recurrence (AR) rates, and Cox regression was used to estimate the hazard ratios (HR). In the analyses, the effect of AST was taken into account. Results: In total, 835 patients with pN0(i-)(sn), 799 patients with pN0(i+)(sn), and 958 patients with pN1mi(sn) were included. AR rates, and HRs on AR are displayed below. Conclusions: Omission of cALND or ax RT in patients with pN1mi(sn) resulted in a significantly higher 5-year AR rate, even after correction for AST, and other patient and tumor characteristics. This indicates that patients with pN1mi(sn) should undergo cALND or ax RT to prevent AR. Support: The Netherlands Organization for Health Research and Development (ZonMw) and the Dutch Breast Cancer Trialists’ Group (BOOG). n 5-year AR(%) HR AR (95%CI)* pN0(i-)(sn) cALND 113 1.9 1.00 pN0(i-)(sn) SN 722 2.2 1.07 (0.23 - 4.94) pN0(i+)(sn) cALND or ax RT 459 1.1 1.00 pN0(i+)(sn) SN 340 1.7 2.14 (0.57 - 7.96) pN1mi(sn) cALND or ax RT 828 1.2 1.00 pN1mi(sn) SN 130 6.2 4.45 (1.46 - 13.54) * Corrected for AST, age, (log) tumor size, grade, hormone receptor status. No significant financial relationships to disclose.
The heritage of Hippocrates
Authors: D. L. Wilbur
Journal: JAMA (1969)

A number of years ago, a physician wrote an article for the widely circulated newspaper supplement, "American Weekly." In it he said this: If a man is good in his heart, then he is an ethical member of any group in society. If he is bad in his heart, he is an unethical member. To me, the ethics of medical practice are as simple as that. That is a beautiful and uncomplicated explantation of a complex subject, and I am sure thousands of readers must have nodded their heads in total agreement and understanding as they read it. It is my opinion, however, that the statement is not valid. It greatly oversimplifies a matter that has been a major concern of the medical profession for hundreds of generations. If it were true, men who are good in their hearts —and I think most of them are, in spite of noisy
Delayed prescribing of antibiotics for upper respiratory tract infection
Journal: BMJ (2005)

the UK and has been withdrawn in many other countries because of reports of aplastic anaemia.It is neurotoxic to humans if ingested or if excessive percutaneous absorption occurs.Some drug can be stored in body fat and excreted in breast milk.Benzyl benzoate is irritant, not used in children, and is not available in the US.
Diseases of the Liver and Biliary System
Authors: Frank Iber
Journal: JAMA (1993)

Medicine lives extensively on tradition and experience. There are very few indeed who have not used and enjoyed Sherlock's liver book since its debut in 1963. From the first it has provided all that the practicing physician in any field needs to know about liver disease. It could be counted upon to present the facts in a concise, well-illustrated way, to provide mature middle-ground guidance on controversial issues, and to offer a clear map to where the research observations would take clinicians in the future. After a four-year interval this ninth edition features a coauthor, a rewriting of about one third, 140 new illustrations—many in color—and a new format. Yet, by sticking to concise writing and avoiding redundancy, the authors have not increased the overall length. The organization is unchanged, but chapters have expanded, or, in a few instances, contracted with changing management. Anatomy, liver function, hematological changes, imaging, and
Erratum: “Evaluation of a Physiologically Based Pharmacokinetic (PBPK) Model for Inorganic Arsenic Exposure Using Data from Two Diverse Human Populations”
Authors: Hisham A. El-Masri, Tao Hong, Cara Henning, William Mendez, Edward E. Hudgens, David J. Thomas, Janice S. Lee
Journal: Environmental Health Perspectives (2018)
Sodium in Processed Foods
Journal: JAMA (1983)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reply
Authors: M Moshkowitz, F M Konikoff, T Gilat
Journal: Gut (1995)

Letters, Notes metronidazole in triple therapy does not improve the efficacy of treatment, but increases the risk of acquisition of metronidazole resistance.Determination of bacterial density in the stomach may have some implications for the eradication of the organism.The urea breath tests, which can detect Hpylori quantitatively, are not routinely available in most units at present.The biopsy dependent rapid urease tests, which are widely used and commercially available, have the potential to determine the bacterial density by measuring the urease activity quantitatively or semi-quantitatively - that is, the greater the number of organisms, the quicker the colour change because of the increased production of ammonia.8The cur- rently applied rapid urease tests, based on agar or liquid media, may need modifications for quantitative detection of H pylori in the stomach.
Physical Diagnosis.
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Appearance of oval cells in the liver of rats after long-term exposure to ethanol
Authors: P SMITH
Journal: Hepatology (1996)

Epidemiological studies show an increased risk of developing liver cancer among alcoholics. There is some agreement that ethanol itself is not carcinogenic, but it may enhance the tumorigenic process by inducing drug-metabolizing enzymes, suppression of the immune system or by affecting DNA repair enzymes. Precisely how ethanol predisposes or promotes the development of hepatoma is unknown. Hepatocarcinogenesis induced by a choline-deficient, ethionine-supplemented (CDE) diet produces extensive alteration of the liver architecture with the emergence and rapid proliferation of oval cells. This study examines whether chronic alcohol consumption induces the proliferation of oval cells. Oval cells induced in rats maintained on a 5% ethanol liquid diet (ELD) for up to 24 months, or fed a CDE diet for up to 4 weeks, are compared using a panel of liver-specific markers. In CDE-treated rats, oval cells staining positively for α-fetoprotein (AFP), π-class glutathione S-transferase (π GST), and the embryonic form of pyruvate kinase (M2-PK) are observed after 1 week. Similar cells are seen in ELD-treated rats after 2 months. Their numbers increase with time, and incorporation of [3H]thymidine confirms they are a dividing population. Acute damage induced by partial hepatectomy and CCI4 poisoning did not induce the appearance of oval cells. We conclude that chronic ethanol consumption induces oval cell proliferation. We suggest that, in addition to other proposed mechanisms, an alteration in cellular composition of the liver be considered as an explanation for the increased incidence of liver cancer among alcoholics.
As more surgeons opt for autologous transfusion route, what's ahead?
Authors: M. F. Goldsmith
Journal: JAMA (1989)

NO TRANSFUSED BLOOD is as safe for a surgery patient as his or her own. And given that it's sometimes impossible to operate with no transfused blood, an increasing number of surgeons are choosing to go the autologous route. A report at the annual meeting in Atlanta, Ga, of the American College of Surgeons drew one map of the possible terrain ahead. Steven A. Gould, MD, associate professor of surgery at Michael Reese Hospital and Medical Center, Chicago, Ill, related its Department of Surgery's experience with the autologous blood program set up in December 1987. Gould credits the success of the comprehensive program in large part to the efforts of its special coordinator, Mary Stankos, RN. Other participants include Arthur L. Rosen, PhD; Lakshman R. Sehgal, PhD; Hansa L. Sehgal, MT; Phillip J. DeChristopher, MD; Armando R. Orlina, MD; and Gerald S. Moss, MD. This Michael Reese program involved 161