tbuckley/cabot-search huggingface dataset:
Reply
Authors: Anna S. F. Lok, Brian J. McMahon
Journal: Hepatology (2007)

In their letter, Dr. Papatheodoridis and colleagues questioned the basis for selecting a cutoff level of hepatitis B virus (HBV) DNA higher than 2000 IU/ml to differentiate hepatitis B e antigen (HBeAg)–negative persons who should be evaluated for chronic hepatitis from those who are in the inactive carrier state. We chose this cutoff level on the basis of the available literature, which suggests that more than 95% of persons having chronic hepatitis B will have HBV DNA levels higher than 2000 IU/ml.1-4 We agree that a small percentage of HBeAg-negative carriers who have persistently normal aminotransferases have serum HBV DNA levels that only intermittently exceed 2000 IU/ml. However, as Papatheodoridis and colleagues indicated, minimal or no inflammation and fibrosis have been found in these persons, and in our experience, HBV DNA levels persistently higher than 2000 IU/ml have not been observed among HBeAg-negative persons with persistently normal aminotransferases. Papatheodoridis and colleagues also indicated that a small percentage of patients with HBeAg-negative chronic hepatitis have serum HBV DNA levels lower than 2000 IU/ml. However, their data and ours show that none of the HBeAg-negative patients with biopsy-documented chronic hepatitis B and abnormal aminotransferases have serum HBV DNA levels persistently lower than 2000 IU/ml. We agree that there is no clear cutoff HBV DNA level that would differentiate inactive hepatitis B surface antigen carriers from patients with HBeAg-negative chronic hepatitis. Therefore, in the recent update of the American Association for the Study of Liver Diseases guidelines, we emphasized the importance of serial testing and the role of liver histology in patients who fall into gray zones.5 Anna S. F. Lok* , Brian J. Mcmahon* , * Division of Gastroenterology, University of Michigan Medical Center, Ann Arbor, MI, Liver Disease and Hepatitis Program, Alaska Native Medical Center and Arctic, Investigations Program, Centers for Disease Control, Anchorage, AK.
Editorial Board
Authors: Daniel Cattran, P Coates, Andrew Davenport, Tilman Drueke, Paris Ckd, Associated Complications, Masaomi Nangaku, Jai Radhakrishnan, New York, Maria Rastaldi, W Reeves, San Antonio, Detlef Schlöndorff, Michael Ross, Qais Al-Awqati, York New, Christina Wyatt, Vic Hasselblad, Jacksonville Zhezhen, Joseph Kim, Yi-Ju Li, , Durham, Dorothea Nitsch, London Ramakrishnan, Anupam Agarwal, Hans Anders, Jonathan Barratt, David Basile, Francois Berthoux, Emmanuel Loire, São Burdmann, Christos Paulo, Yi-Pu Paris, Erik Chen, Steven Christensen, New Coca, Terence York, London Cook, D Vivette, New Agati, Farhad York, John Danesh, Ian Chicago, Marc De Boer, Antwerp De Broe, Vikas Zurich, St Dharnidharka, Kent Louis, Zheng Doi, Adriana Dong, Kai-Uwe Oviedo, Erlangen Eckardt, Eiam-Ong Somchai, Michael Emmett, Dallas Endre, Sydney Evan, Pieter Evenepoel, Sarah Leuven, Denver Faubel, Fernando Faul, Rochester Fervenza, Danilo Mineola, Jürgen Homburg, Agnes Aachen, Alessia Nashville, Barry Miami, Winston-Salem Freedman, Isehara Masafumi Fukagawa, Vesna Garg, Rochester Garovic, Laguna Glassock, Glenda Niguel, David Gobe, New Goldfarb, Matthew York, Mark Griffin, Angeles Haas, John Haase, Cijiang He, Michelle Hladunewich, Thomas Hostetter, Chi-Yuan Cleveland, San Hsu, Tobias Francisco, Benjamin Huber, St Humphreys, Reiko Louis, Jula Tokyo, Dallas Inrig, Francisco Kirsten Johansen, Roberto Kamyar Kalantar-Zadeh, Iowa Kalil, Yashpal City, Chicago Kanwar, New Kaskel, Krzysztof York, York Kiryluk, Clayton Kitching, Matthias Kopp, Ann Kretzler, Christian Arbor, Christophe Bonn, Paris Legendre, Los Lemley, Adeera Angeles, Philip Levin, Hong Li, Christoph Kong, John Toronto, Rochester Lieske, Jiannong Little, Kathleen Liu, San Liu, Youhua Francisco, Zhi-Hong Liu, Nanjing Liu, Dallas Lu, Matthias Berlin, Johannes Mack, Peter Mann, Hamilton Margetts, New Glen Markowitz, Ziad York, Kunihiro Amiens, William Matsushita, Atlanta Mcclellan, Timothy Mehrotra, Palo Meyer, Jeffrey Alto, St Miner, William Louis, Houston Mitch, Jeremiah Moeller, St Morrissey, Rosa Louis, São Moysés, Rama Paulo, Peter Duarte, David Nelson, Clayton Nikolic-Paterson, Klaus Charlottesville, Juan Oliver, York Charles O'neill, Atlanta Panzer, Mark Perazella, New Haven, Janos Peti-Peterdi, Los Angeles, Laura Plantinga, Atlanta Pollak, Didier Boston, Ambra Charlottesville, Susan Pozzi, Chicago Quaggin, Jochen Reich, Giuseppe Reiser, Sharon Bergamo, Mariano Clayton, Mitchell Rodriguez, Robert Rosner, Simone Safirstein, New Sanna-Cherchi, Antonio York, Kai Santoro, New Schmidt-Ott, Stephan York, Aarau Segerer, Sharma Kumar, La Jolla, Katalin Susztak, Tetsuhiro Tanaka, Tokyo Sydney, C Tang, Hong Kong, Ravi Thadhani, Joshua Boston, Jens Denver, Marcello Nashville, Frank Tonelli, Manjeri Van Der Sande, San Venkatachalam, Carsten Antonio, Joel Wagner, Ann Weinberg, Matthew Arbor, Donald Weir, Temple Wesson, Jack Westenfelder, Adam Wetzels, Myles Whaley-Connell, Keng-Thye Durham, Kwan-Dun Woo, Taiwan Wu, Yusuke Suzuki, Tokyo Zeisberg
Journal: Kidney International (2017)
Errata
Journal: Circulation Research (1959)

Page 86 Right column; sentence starting with line 6 should read as follows: A tracheal cannula was inserted; a femoral vein was cannulated for subsequent intravenous injections and systemic blood pressure was recorded from a common carotid artery connected to a mercury manometer or by a Statham transducer. Page 90 Left column; sentence starting with line 7 should read as follows: Since the same concentration (0.003 per cent) was used with both drugs, it appears that these agents are equally effective in raising the threshold of response to electrical stimuli.
The heart and circulation under stress of Olympic conditions
Authors: R. J. Shephard
Journal: JAMA (1968)

The nature and extent of the stresses imposed upon the heart and circulation by Olympic competition varies markedly with the type of event. It is thus helpful to make an arbitrary classification of some of the main Olympic contests on the basis of the dominant physiological requirements (Table 1). The atmosphere of competition imposes an intense psychological stress upon all contestants, and this necessarily acts upon the cardiovascular system. However, psychological stress is greater during anticipation of exercise than during actual performance. Other factors being equal, the cardiovasular effects of psychological stress are thus likely to be greatest in brief repetitive events (categories 4 and 1 of Table 1). All forms of exercise tend to increase the systolic blood pressure. However, certain types of circulatory strain seem related to the mean rather than to the systolic pressure. Elevation of the mean systemic pressure is a particular feature of sustained isometric
Mortality After Myocardial Infarction-Reply
Authors: Eve Weinblatt
Journal: JAMA (1983)

<h3>In Reply.—</h3> A serious view of epidemiology as a discipline must reject the comparisons made by Dr Zumoff on an issue of public health importance. Between 1968 and 1976, mortality from coronary heart disease (CHD) declined in the United States by more than 20%, while before this, it had been rising. From two large earlier studies of patients with CHD in the Health Insurance Plan (HIP) of Greater New York, New York, we identified diagnostically comparable male survivors of a first myocardial infarction—436 men followed up in the 1960s and 697 in the 1970s. Controlling for important clinical influences on prognosis, we found no secular improvement in long-term survival during this time period (<i>JAMA</i>1982;247:1576). Since the evidence on temporal changes in coronary risk factors since the late 1960s suggested that these alone could not have produced the total decline in mortality that had occurred, we concluded that the survival
Photomicrographs of Spirochetes, Entamebas, Plasmodia Trypanosomes, Leishmania, Negri Bodies and Parasitic Helminths.
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Psychological support.
Authors: P Terry, L Hardy, G Jones, S Rodgers
Journal: British Journal of Sports Medicine (1997)

In addition to CD4+CD25+Foxp3+ Tregs, natural and induced CD8+ Tregs have been described. Here we report our progress in generating human CD8+ Tregs ex-vivo. Naïve CD8+ cells were activated with anti-CD3/28 beads with IL-2 ± TGF-β for 1 to 9 days. As with CD4+ cells, TGF-β markedly enhanced expression of Foxp3. TGF-β also enhanced CD122, CD103, and PD-1, but decreased granzymes, HLA-DR, CD80 and CD86 expression. Sustained Foxp3 expression and suppressive function was IL-2 dependent. Secondarily stimulated CD8+ cells proliferated weakly, and suppressed activation, proliferation and cytokine production by CD4+ cells in vitro. In vivo functional activity was assessed in NOD SCID IL-2R cγ chain-/- mice injected with allogeneic human PBMC. While human CD4+Foxp3+ Tregs doubled survival from GVHD, CD8 Regs, remarkably, quadrupled survival. Only previously activated CD8+ cells had suppressive activity and protection was unrelated to Foxp3 expression. Adding retinoic acid or rapamycin to TGF-β did not improve survival. By contrast, these activated CD8+ cells rapidly expressed TNFR2 and PDL-1 within one day, and at all time points studied only cells expressing these markers had suppressive activity. Suppressive activity in vivo was IL-10 dependent and partially TGF-β dependent. Thus, in agreement with functional CD8regs described in lupus, diabetes and multiple sclerosis, protective CD8 regs can be induced ex-vivo, and the therapeutic potential of TNFR2, PDL-1+ cells should be carefully explored.
Combined First Annual Scientific Session of the Society for Clinical Trials and Seventh Annual Symposium for Coordinating Clinical Trials
Journal: JNCI Journal of the National Cancer Institute (1979)

Combined First Annual Scientific Session of the Society for Clinical Trials and Seventh Annual Symposium for Coordinating Clinical Trials Get access JNCI: Journal of the National Cancer Institute, Volume 63, Issue 4, October 1979, Page 1105, https://doi.org/10.1093/jnci/63.4.1105-b Published: 01 October 1979
The 'How' and the 'Whys' of Immediate Fitting
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SOME EFFECTS OF OVERDOSAGE WITH VIOSTEROL
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Recent Progress in Hormone Research: The Proceedings of the Laurentian Hormone Conference (1947). Volume III
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Eroded Cervix
Authors: U. M. Kroll
Journal: BMJ (1970)

During a six-year period 1,808 women aged 20 to 59 underwent gynaecological examination at a well-woman clinic. Cervical erosions were found in 269. Nine patients had cervical carcinoma, confirmed by biopsy; of these eight had eroded cervices. The remaining patients with non-malignant erosions were examined at six-monthly intervals. Of these, roughly 39% showed spontaneous healing within a year, 31% responded to medical treatment, 17% healed only after surgical treatment, 9% remained unhealed when reviewed six months after the last active treatment, and 4% relapsed after originally healing well.The difficulties of getting patients to return for cytological examination increase with the interval between the original examination and recall. It is suggested that patients should be re-examined initially at an interval not exceeding six months, so that false negative results are minimal.
Natural History of Tuberculosis in the Human Body: V. Prognosis Among Tuberculin Reactor Children from Birth to Five Years
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A RECORD NEURAL ACTIVITY
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Wellness Checkpoint
Authors: Louis Hugo Francescutti
Journal: JAMA (1994)

The most powerful section of the program, the Wellness Assessment, begins after a rather tedious introduction. Through a series of more than 130 directed questions dependent on the user's sex and family history, the program determines a summary Wellness Risk Score consisting of family- and lifestyle-related factors. The yes-no and multiplechoice questions take about 20 minutes to complete. Topics incorporated into the scoring system include one's habits (smoking, alcohol, diet, medication, exercise, and driving), environment (work, home, and sun), social climate (stress and marital status), health indicators (blood pressure, cholesterol, diabetes, weight, and age), and hidden risks (family history). This aspect of the program is particularly useful because it provides a detailed printed personal summary of one's individual assessment risk. After taking the assessment, one is given the opportunity to go back and set new personal goals in each category. The program then recalculates one's overall risk and lists the
Chemotherapy of Cancer
Authors: Thomas C. Hall, Genevieve Cole
Journal: New England Journal of Medicine (1962)

Antimetabolites Glucose metabolism. Early work by Warburg13 showed that tumor cells possessed a high rate of anerobic glycolysis. He thought that this observation could explain the etiology and pathogenesis of tumors because of the possibility that interference with the respiration of growing cells could result in a mutational change leading to a characteristic form of glycolysis and thence to neoplastic growth. However, during the past ten years, it has become apparent that although there is a high rate of glycolysis in tumor cells, this may not be the major pathway for providing metabolic energy to the cancer cell, and the . . .
Book Review Text-Book for Nurses . By E. W. H. Groves, M.D., B.Sc., M.S., F.R.C.S.; and the late J. M. Fortescue-Brickdale, M.A., M.D. (Oxon.), M.R.C.P. (Lond.). Oxford University Press; Humphrey Milford. 1930.
Journal: New England Journal of Medicine (1931)
Pathobiology Annual. Volume 4: 1974.
Journal: Annals of Internal Medicine (1975)

Counterelectrophoresis on Human Serum in Coxsackie Virus InfectionsEncouraging results have been obtained by Schmidt et al (1968;1973) on the diagnosis of Coxsackie infections using gel diffusion for demonstration of anti- body in patients' sera.They found that with concentrated Coxsackie antigens human serum pro- duced a group line close to the antigen cup with antigens not necessarily of the infecting virus type, and a specific line, closer to the serum cup, consisting of IgM antibody combined with intact virus particles, of the current infecting virus type, or occasionally with virus for which the serum had a high neutralizing anti- body level.When antigen was inactivated by heat- ing at 56°C for 30 min the specific antigen was converted to group antigen.Counterelectrophoresis should theo- retically enable a less concentrated antigen to be used and be more rapid than simple gel diffusion, but preliminary studies have proved disappointing.Counterelectrophoresis and antigen preparation were as described (Mac-William and Cook, 1975).Antigens
Detection of Mutagenic Activity in the Urines of Anesthesiologists: A Preliminary Report
Authors: Elena C. McCoy, Riva Hankel, Herbert S. Rosenkranz, Joseph G. Giuffrida, Dante V. Bizzari
Journal: Environmental Health Perspectives (1977)

While halothane was without mutagenic activity in the Salmonella mutagenicity assay, even in the presence of microsomal fractions, the urines of anesthesiologists induced mutations of the base-substitution type.
Acute abdominal pain
Authors: T. E. Shea
Journal: JAMA (1967)

Dr. Joseph T. Ferrucci, Jr.: A 63-year-old white woman, who lived in a nursing home because of slowly progressive syringomylelia, was admitted to the hospital complaining of abdominal pain of one day's duration. The pain had occurred spontaneously, had radiated to the back, but was primarily located in the lower abdomen. Catheterization of the bladder by a nursing home attendant gave incomplete relief of pain. Several hours later she was given an enema. The material which was evacuated contained blood. She was then transferred to this hospital where she was found to have an elevated blood pressure of 200/110 mm Hg. She was afebrile; the pulse was regular at 80 beats per minute. A roentgenogram of the abdomen was obtained. <h3>Discussion</h3> Dr. Laurence L. Robbins: Dr. Wyman, how do you interpret this? Dr. Stanley M. Wyman: I am concerned about her small-bowel pattern. There are several dilated small-bowel loops. She