tbuckley/cabot-search huggingface dataset:
Congener-Specific Levels of Dioxins and Dibenzofurans in U.S. Food and Estimated Daily Dioxin Toxic Equivalent Intake
Authors: Arnold Schecter, James Startin, Christopher Wright, Mitchell Kelly, Olaf Papke, Anton Lis, Michael Ball, James R. Olson
Journal: Environmental Health Perspectives (1994)

Food, especially meat, milk, and fish, is the immediate source of almost all polychlorinated dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and dioxinlike compounds in the general population. To estimate intake of these highly toxic compounds, we performed congener-specific dioxin analyses for the first time on U.S. food for 18 dairy meat, and fish samples from a supermarket in upstate New York. 2,3,7,8 Tetrachlorodibenzo-p-dioxin (TCDD, "dioxin") toxic equivalents (TEqs) on a wet weight basis for the dairy products ranged for 0.04 to 0.7 ppt, meat TEqs ranged from 0.03 to 1.5 ppt, and fish TEqs ranged from 0.02 to 0.13 ppt. Previous human breast milk and infant formula analyses were used with the current preliminary food data to estimate a range of dioxin intake for Americans. Average daily food intake of TEqs for an adult weighing 65 kg was estimated to be between 0.3 and 3.0 pg/kg body weight, for a total of 18-192 pg TEq, using 1986 American consumption rates. Due to the relatively high level of PCDDs and PCDFs commonly found in human breast milk from American women and from women in other industrial countries, a nursing infant may consume an average of 35-53 pg TEq/kg body weight/day in its first year of life. This may be compared with the current U.S. EPA virtually safe dose of 0.006 pg TCDD/kg body weight per day over a 70-year lifetime based on an upper limit cancer risk of 10(-6), or the 10 pg/kg/day used by some European government agencies.
Book Review Help Your Doctor to Help You When You Have Sick Headache or Migraine . Edited by Walter C. Alvarez, editor-in-chief, George Blumer, Logan Clendening, Irving Cutter, Howard W. Haggard, Rudolph Matas, Charles W. Mayo, George R. Minot, John H. Stokes and George H. Whipple. 8°, cloth, 37 pp. New York: Harper and Brothers, 1941. 95 cents.
Journal: New England Journal of Medicine (1941)
JAMA Psychiatry
Authors: Phil Fontanarosa, Annette Flanagin, Brenda Gregoline, Tracy Frey, Shannon Sparenga, Miriam Cintron, Paul Ruich, Suzanne Walker, Diane Cannon, Connie Manno, Fred Marshall, Catherine Copyreaders, Stephanie Alden, Jan Beckmeyer, Mary Clavey, Paula Coerver-Connolly, Laura Glitman, Kenneth King, Donna Lane, Caroline Thordsen, Wanda Assistant, Larry Bryant, Monica Mungle, Elaine Williams, Kathryn Brokke, Fanny Brown, Paul Frank, Lenette Gardner-Gullens, Peter Kim, Rachell Lozano, Michaela Mark, Elizabeth Scientifi, Michael Berkwits, Michelle Kurzynski, Eric Butkus, Will English, Mustafa Ishaq, Daniel Morrow, Reuben Rios, Ronna Henry, Joshua Bird, Karen Bucher, Samantha Welker, David Song, Deputy Livingston, Thomas Cole, Marla Hall, Deanna Willis, Yolanda Davis, Joseph Thornton, Preeti Malani, Deanna Bellandi, Jim Periodical, Thomas Easley, Brian Shields, Monica Smith, Jeff Ery, J Bonistalli, Kathy Russell, Mirna Monal, Stacey Mchugh, Marketing Thornbury, Tricia Classifi, Thalia Moss, Mike Harvey, Susan Henning, Saskia Bolore, Gretchen Linder, Brian Mccartney, David Baum, Rebecca Haas, Christine Hearne, Natasha Nekola, Ron Marketing, Paul Gee, Matt Herron, Elizabeth Solaro, Geoff Rey, Rick Bell, Lindsay Dawson, Craig Mccaff Rey, Michael Mcgraw, Romando Rossini, Stacy Staff, Millette Jackson-Bates, Karen Adams-Taylor, Karl Elvin, Jaye Mize, Sean O'donnell, Sue Managers, David Antos, Chris Borden, Debbie Camp, Lydia Cruz, Scott Curl, Diane Darnell, Colleen Kelly, Chris Meyer, Annemarie Neff, J Neff, Sean Ohlson, Phil O'leary, Bill Pedone, Susan Price, Denise Steinhauser, Joe Advertising, Production Services, Kim Boler, Rhonda Brown, Daniel Degroot, Jordynn Farrar, Euwanaha Joiner-Smith, Cindy Rendlen, Ellen Yoshihara, Circulation Services, Julie Burton, Dexter Golden, Erin Hinchcliff, Noemi Rivera, Geneine Van, Someren Composition, New Media, Gail Barrett, Regina Brownlee, Amanda Camino, Brenda Chandler-Grayer, Emily Dunn, Amy Evers, Teri Hutchison, Mary Kuranda, Joshua Lampinen, Nathan Mitre, Patricia Panek, La Son, Diggs Sledge, George Thomson Graphics, Joe Amft, Maria Duda, Fred Furtner, Carolyn Hall, Maria Kowalkowski, Proofreading Carol, Joy Farrell, Daniel James, Judith Literskis, Teresa Omiotek, Michael Ryder, James Madara, Bernard Hengesbaugh, Dan Blazer, North Carolina, David Braff, La Jolla, Naomi California, Stephen Breslau, Washington Dager, Atlanta Druss, Susan Georgia, New Essock, New York, Ellen York, John Hardy, James Harris, Maryland Shitij Kapur, Kenneth Kendler, Virginia Ronald, C Kessler, Kathleen Merikangas, Maryland Samples O'malley, Michael Owen, Fmed Sci, Judith Rapoport, Maryland Charles, F Reynolds, Myrna Weissman, Naomi Wray, Charles Zorumski, St Louis, Roy Grinker Sr, Daniel Freedman, Jack Barchas, Joseph Coyle, Jennifer Urbano Blackford, Dost Öngür, Ira Phillips, Helena Chmura Kraemer, Howard Bauchner
Journal: JAMA Psychiatry (2016)
The Battered-Child Syndrome
Authors: C. Henry Kempe
Journal: JAMA (1984)

The battered-child syndrome, a clinical condition in young children who have received serious physical abuse, is a frequent cause of permanent injury or death. The syndrome should be considered in any child exhibiting evidence of fracture of any bone, subdural hematoma, failure to thrive, soft tissue swellings or skin bruising, in any child who dies suddenly, or where the degree and type of injury is at variance with the history given regarding the occurrence of the trauma. Psychiatric factors are probably of prime importance in the pathogenesis of the disorder, but knowledge of these factors is limited. Physicians have a duty and responsibility to the child to require a full evaluation of the problem and to guarantee that no expected repetition of trauma will be permitted to occur.
Hyperparathyroidism and pancreatitis. Chance or a causal association?
Authors: M. A. Bess
Journal: JAMA (1980)

Of 1,153 patients with surgically confirmed primary hyperparathyroidism operated on at the Mayo Clinic between 1950 and 1975, only 17 (1.5%) had coexisting or prior pancreatitis. This frequency of association approximates the reported incidence of pancreatitis among general hospital patient populations. Other factors of possible etiologic significance in pancreatitis, such as gallstones or alcohol abuse, were present in 11 of the 17 patients. Cure of the hyperparathyroidism was usually not associated with amelioration of symptoms due to pancreatitis. A review of the available data, including experimental evidence, does not support a cause-and-effect relationship between primary hyperparathyroidism or hypercalcemia and pancreatitis. (<i>JAMA</i>243:246-247, 1980)
Effects of Low Carbohydrate Diet and Diabetes Mellitus on Plasma Concentrations of Glucose, Non-esterified Fatty Acid and Insulin During Oral Glucose Tolerance Tests
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Manuscripts Approved for JNCI, April 1 to May 1, 1967
Journal: JNCI Journal of the National Cancer Institute (1967)

Manuscripts Approved for JNCI, April 1 to May 1, 1967 Get access JNCI: Journal of the National Cancer Institute, Volume 38, Issue 6, June 1967, Page 999, https://doi.org/10.1093/jnci/38.6.999 Published: 01 June 1967
Cell Signaling Pathways Elicited by Asbestos
Authors: Brooke T. Mossman, Steven Faux, Yvonne Janssen, Luis A. Jimenez, Cynthia Timblin, Christine Zanella, Jonathan Goldberg, Eric Walsh, Aaron Barchowsky, Kevin Driscoll
Journal: Environmental Health Perspectives (1997)

In recent years, it has become apparent that minerals can trigger alterations in gene expression by initiating signaling events upstream of gene transactivation.These cascades may be initiated at the cell surface after interaction of minerals with the plasma membrane either through receptorlike mechanisms or integrins.Altematively, signaling pathways may be stimulated by active oxygen species generated both during phagocytosis of minerals and by redox reactions on the mineral surface.At least two signaling cascades linked to activation of transcription factors, i.e., DNA-binding proteins involved in modulating gene expression and DNA replication, are stimulated after exposure of lung cells to asbestos fibers in vitro.These include nuclear factor KB (NFicB) and the mitogen-activated protein kinase (MAPK) cascade important in regulation of the transcription factor, activator protein-1 (AP-1).Both NFicB and AP-1 bind to specific DNA sequences within the regulatory or promoter regions of genes that are critical to cell proliferation and inflammation.Unraveling the cell signaling cascades initiated by mineral dusts and pharmacologic inhibition of these events may be important for the control and treatment of mineral-associated occupational
Scientific and Ethical Aspects of Human Monitoring
Authors: Arthur L. Frank
Journal: Environmental Health Perspectives (1996)

Screening and monitoring activities have their place in the prevention of workplace and environmental disease and injury.Testing, while still relatively nonspecific at this time, can be appropriately used in such prevention activities.Unfortunately, such information can also be misused or even put to malevolent purpose, and this complicates the moral and ethical aspects of such testing.With advances in molecular biology, one can anticipate more refined and individualized testing in the future.
Enforcing informed consent requirements: form or substance?
Authors: R. R. Faden
Journal: JAMA (1989)

In his article "Enforcing Patient Preferences: Linking Payment for Medical Care to Informed Consent," in this issue ofThe Journal,<sup>1</sup>Kapp argues that many medical interventions currently are being imposed on patients in the absence of voluntary, competent, and informed consent. He proposes that utilization review organizations link financial reimbursement for medical services to "a requirement of valid patient (or surrogate) consent."<sup>1</sup>The proposal by Kapp is that individual and institutional health care providers will not be paid for a medical service unless a signed consent form covering that service is found in the patient's chart. There are difficulties in Kapp's formulation of the problem, and many more with his formulation of the solution. With regard to the problem, although empirical research is limited, there is indeed evidence of a gap between the rhetoric of informed consent and the frequency with which physicians involve patients in medical decisions
Editorial Board
Authors: Gail Shapiro, Lanny Rosenwasser, Wash Denver, D Metcalfe, Immediate Past, William Busse, Robert Rich, James Kemp, Atlanta Ga, San Diego, Robert Bush, Louis Mendelson, West Hartford, Thomas Casale, Lawrence Schwartz, William Henderson, Seattle Wash, William Shearer, Robert Lemanske, Gillian Shepherd, New York, Gailen Marshall, Donald Leung, Colo Deputy, Harold Nelson, Stanley Szefler, Colo Associate, James Crapo, Erwin Gelfand, Gary Larsen, Bruce Bochner, Philip Norman, Kay Whalen
Journal: Journal of Allergy and Clinical Immunology (2002)
THEORY AND PRACTICE.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Jet vaccination.
Journal: BMJ (1970)

JMILissue of the B.M.J. illustrates the dramatic effects of one variety of infection.In a recent influenza epidemic in.Birmingham 29 patients were admitted to hospital with ketoacidosis.Three died apparently from loss of potassium.Seven were not hitherto known to be diabetic.Though it is not uncommon for ketoacidosis to be the presenting feature of diabetes, it usually occurs in young, insulin-dependent patients.While infection is a fairly common cause of diabetic keto- acidosis and should always be sought, it is not the most common cause.In the, series of 100 cases described by J. Sheldon and D. A. Pyke3 and in the 72 cases of P. Taft and colleagues4 the single most common cause was mismanagement of the diabetes, usually by the patient, occasionally by the doctor.This mismanagement included apparent dis- regard of warning symptoms or signs, deliberate omission or reduction of insulin by the patient, and inappropriate change from insulin to one of the oral drugs.Though better education of doctor and patient could help to prevent some of these misadventures, in many cases the patient stops taking insulin for emotional reasons.Adolescents are specially prone to do this as a means of escape from a difficult situation or as a protest or an appeal for help.Emotional stress in itself may provoke ketoacidosis in some patients, and they may be aware of the relationship and present themselves promptly for treatment.4; Of the other known aetiological factors, vomiting from any cause and undiagnosed diabetes are the most common.3In many cases there is no obvious precipitant.In women it is worth considering a relationship with menstruation if no other cause can be found.6Though ketoacidosis is now an uncommon cause of death in diabetics, it carries an appreciable mortality and should be treated as a medical emergency.Treatment of the established condition requires all the refinements of the well-equipped hospital and laboratory.Lesser degrees of ketosis may safely be treated at home so long as the patient is seen frequently and the situation kept under review.Vomiting or impairment of consciousness are indications for admission to hospital, which should also be promptly sought for children and for insulin-dependent diabetics known to be unstable.
Paradoxic Paradoxes
Authors: C. David Naylor, John W. Frank
Journal: Annals of Internal Medicine (1992)

Letters15 September 1992Paradoxic ParadoxesC. David Naylor, MD, DPhil, John W. Frank, MD, MScC. David Naylor, MD, DPhilSearch for more papers by this author, John W. Frank, MD, MScSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-117-6-534 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors:Brown and colleagues (1) described a "policy makers' paradox" with respect to preventive health strategies and alluded to divergent recommendations made by the National Cholesterol Education Program in the United States and the Toronto Working Group on Cholesterol Policy in Canada. Although we thank Brown and colleagues for their interest in our work, their speculation about the reasons for our "different resolution" of the "policy makers' paradox" was unnecessary. If Brown and colleagues had read the primary sources rather than an editorial by Garber (2), they would have found discussion of the various issues in preventive policy...References1. BrownViscoliHorwitz ECR. Preventive health strategies and the policy makers' paradox. Ann Intern Med. 1992;116:593-7. LinkGoogle Scholar2. Garber A. Where to draw the line against cholesterol. Ann Intern Med. 1989;111:625-7. LinkGoogle Scholar3. . Asymptomatic hypercholesterolemia: a clinical policy review. J Clin Epidemiol. 1990;43:1021-22. MedlineGoogle Scholar4. Rose G. Strategy for prevention: lesson from cardiovascular disease. Br Med J. 1981;282:1847-51. CrossrefMedlineGoogle Scholar5. Rose G. Sick individuals and sick populations. Int J Epidemiol. 1985;14:32-8. CrossrefMedlineGoogle Scholar1. BrownViscoliHorwitz ECR. Preventive health strategies and the policy makers' paradox. Ann Intern Med. 1992;116:593-7. LinkGoogle Scholar2. Rose G. Strategy of prevention: lessons from cardiovascular disease. Br Med J. 1981;282:1847-51. CrossrefMedlineGoogle Scholar3. Cochrane A. Effectiveness and Efficiency. Abingdon: Burgess and Son; 1972. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: C. David Naylor, MD, DPhil; John W. Frank, MD, MScAffiliations: University of Toronto North York, Ontario M4N 3M5 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCommentary: A radical future for public health 15 September 1992Volume 117, Issue 6Page: 534-535KeywordsCholesterol ePublished: 1 December 2008 Issue Published: 15 September 1992 PDF downloadLoading ...
EORTC Symposium on New Approaches to Cancer Therapy
Journal: JNCI Journal of the National Cancer Institute (1980)

Journal Article EORTC Symposium on New Approaches to Cancer Therapy Get access JNCI: Journal of the National Cancer Institute, Volume 65, Issue 1, July 1980, Page 211, https://doi.org/10.1093/jnci/65.1.211-a Published: 01 July 1980
Giant "A" Wave of the Left Atrial Appendage
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hepatic stellate cell autophagy promotes HCC progression via GDF15
Authors: Yuta Myojin, Hayato Hikita, Masaya Sugiyama, Takahiro Kodama, Yuki Makino, Tasuku Nakabori, Ryoko Yamada, Ryotaro Sakamori, Tomohide Tatsumi, Mizokami Masashi, Tetsuo Takehara
Journal: Journal of Hepatology (2020)
Myeloablative therapy with autologous bone marrow transplantation as consolidation of remission in patients with follicular lymphoma
Authors: A. Z. S. Rohatiner, C. G. A. Price, S. Arnott, A. Norton, M. L. Evans, F. Cotter, E. Dorey, C. L. Davis, P. Clark, J. Sterlini, J. Lim, M. Horton, T. A. Lister
Journal: Annals of Oncology (1991)
A Correction
Journal: BMJ (1932)

BRITISHNAfollowing treatment helpful: (1) Deep breathing with light Swedish drill for the abdominal organs for about five minutes in the morningf, with general massage all over the body with a rough towel afterwards.(2) Breakfast to be dry, with milky tea or coffee and no sugar taken about one and a half hours afterwvaids.Dinner should also be taken dry and well masticated, particularly all starchy
Internal Secretion in Health and Disease.
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ELECTROENCEPHALOGRAPHY
Authors: HALLOWELL DAVIS
Journal: JAMA (1941)

Electricity and electrical instruments have become commonplace features of present day life. Electric light, telephones, radios and electric motors are all about us, and "volts" and "amperes" are so familiar as to appear even in the comic strips of our daily newspapers. Electrical ways of doing things are numerous in the operating room, the clinic and the laboratory, from electrocautery and diathermy to roentgen ray and electrometric titrations. But few electrical instruments in the hospital, with the outstanding exception of the electrocardiograph, represent true contributions of physiology or, more particularly, electrophysiology to medicine. Most of our other electrical instruments are useful tools with which the healthy body can be studied or the sick body treated, but they do not deal primarily with the electrical phenomena or properties of the body itself. Electrophysiology has been willing and eager to make its contributions, sometimes in fact even too eager, but its misfortunes
Data Errors and Incorrect Version of Clinical Prediction Tool Used
Journal: JAMA (2019)

Evan Wood, MD, PhD, FRCPC; Loai Albarqouni, MD, MSc; Stacey Tkachuk, BSc, Pharm; Carolyn J. Green, PhD; Keith Ahamad, MD; Seonaid Nolan, MD, FRCPC; Mark McLean, MD, FRCPC; Jan Klimas, PhD, MSc