tbuckley/cabot-search huggingface dataset:
Otolaryngology—Head and Neck Surgery
Authors: Michael E. Johns
Journal: JAMA (1994)

Our understanding of the biology and genetics of oncogenesis of the upper aerodigestive tract continues to advance steadily with approaches similar to those described in carcinoma of the colon and breast. Boyle et al<sup>1</sup>have noted that the incidence of p53 mutations increases from noninvasive to invasive neoplasms of the mucosa of the head and neck. The findings suggest that p53 mutations are early events in the development of squamous cell carcinoma (SCC) of the head and neck. However, the peak incidence of p53 mutations occurs after tumor initiation, which renders their detection less useful as a screening strategy than it might be for other malignancies such as bladder or colon cancer. The authors also analyzed the anatomic locations of the p53 mutations and found them to be similar to those found in other tobacco-induced cancers such as carcinoma of the lung. Metachronous tumors in the same anatomic region
International views on alcohol and traffic safety.
Journal: BMJ (1974)

box system has been widely used; but it has been often proved difficult to set up and adjust.Modifications such as the cannu- lation of both nares2 19 have recently been described and make the system easier to use.Further trials are clearly needed of methods which do not require the high degree of medical and nursing skills and complex apparatus which the U.C.H. group have employed so successfully.What is required is a technique which can be set up quickly and easily in the special care unit of any maternity hospital.
Obesity
Authors: Adam Gilden Tsai, Daniel H. Bessesen
Journal: Annals of Internal Medicine (2019)

The role of internists in evaluating obesity is to assess the burden of weight-related disease, mitigate secondary causes of weight gain (medications, sleep deprivation), and solicit patient motivation for weight loss. Internists should assess these factors and emphasize the importance of weight loss for the individual patient. All patients wishing to lose weight should be encouraged to monitor their diet and physical activity and should be referred to high-intensity behavioral programs. Some patients with obesity may also benefit from pharmacotherapy or bariatric surgery.
Lessons from the Flood: Will Floyd Change Livestock Farming?
Authors: Charles W. Schmidt
Journal: Environmental Health Perspectives (2000)

When Hurricane Floyd struck eastern North Carolina in September 1999, as many as 50 waste lagoons, many of them several acres in size, were inundated by flood waters. Five lagoons breached, and waterborne animal waste produced nutrient pollution and raised the potential for exposure to pathogens and the risk of disease. As the state recovers, a common question being asked is whether state livestock regulations, particularly regarding facility siting and waste management methods, will be revised to accommodate future flood conditions.
JAMA 75 YEARS AGO
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Herbal health.
Journal: Environmental Health Perspectives (1998)

Herbal HeafthAds for herbal medicines are everywhere these days, encouraging consumers to treat themselves "the natural way" for everything from asdtma to hypertension.What do we really know about these products-and what more do we need to learn?These questions were addressed at the Intemational Workshop to Evaluate Research Needs on the Use and Safety of Medicinal.
The impending epidemic: insulin resistance syndrome (IRS) in a representative sample of youth in Quebec, Canada.
Authors: Gilles Paradis, Marie Lambert, Jennifer L O’Loughlin, Claudette Lavallee, Emile Levy, Edgar Delvin
Journal: Circulation (2001)

P69 Background: Although its prevalence is increasing in adults, there are no data available on precursors of type 2 diabetes, particularly IRS, from representative samples of children in North America. Methods: The Quebec Youth Heart Survey was designed to study the behavioral, biological and genetic correlates of CVD risk factors in a representative probability sample of Quebec youth surveyed with an age-specific questionnaire, standardized clinical measurements and a blood draw during Winter 1999. We studied the correlates of IRS among 735, 773 and 842 individuals aged 9, 13 and 16 years respectively (79.6% French-Canadians). Response rates were 80% for questionnaire and clinical measures and 58.4% for blood draw. Those who declined blood draw were not significantly different for gender, blood pressure (BP), weight, smoking status, urban or rural residence or parental income or education. All biochemical measures were CDC-standardized. Results: In all age-sex categories, HDL-C levels decreased significantly across insulin quartiles while triglycerides (TG), glucose, BMI, tricipital and subscapular skinfolds and BP increased (all p &lt; 0.01). In contrast, no consistent association was observed between insulin quartiles and total cholesterol, LDL-C and apoB. In all age-sex categories, the number of other CVD risk factors (glucose ≥ 6.1 mmol/L, BMI ≥ 85th percentile, systolic BP ≥ 90th percentile, and dyslipidemia (upper quartile for TG and lower quartile for HDL-C) increased significantly across insulin quartiles (all p &lt; 0.001). The prevalence of IRS (defined as 3 or more of hyperinsulinemia (upper quartile) or other CVD risk factors listed above) was as follows: 5.2% and 5.1% of 9-year old boys and girls, 6.9% and 6.7% of 13-year old boys and girls, 9.0% and 5.8% of 16-year old boys and girls, respectively. The prevelence of IRS was similar in French-Canadians and those of other ethnic origins. Conclusion: IRS is highly prevalent in youth, even among children as young as 9 years old and is associated with an atherogenic profile which, if it persists in adulthood, could be associated with a substantial public health burden in the near future.
From the Institute of Medicine
Authors: W. J. McNerney
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
S hemoglobinopathy in a community hospital. Incidence and control
Authors: T. J. Moran
Journal: JAMA (1972)

A rapid and reliable screening test for S hemoglobin (Sickledex) employed on all Negro patients admitted to a community hospital over an 18-month period showed an overall incidence of S hemoglobin of 6.2%. Prompt notification of positive results to the physician apparently has resulted in better prevention and control of complications of S hemoglobinopathy, especially in surgical patients with sickle cell trait (hemoglobin AS). A wallet identification card has been developed to alert both patient and physician to the possibility of unexpected complications in emergency situations.
Subgroup analysis of patients with metastatic colorectal cancer (mCRC) treated with regorafenib (REG) in the CORRECT trial who had progression-free survival (PFS) longer than 4 months.
Authors: Axel Grothey, Alfredo Falcone, Yves Humblet, Olivier Bouche, Laurent Mineur, Antoine Adenis, Josep Tabernero, Takayuki Yoshino, Heinz-Josef Lenz, Richard M. Goldberg, Lei Xu, Andrea Wagner, Eric Van Cutsem
Journal: Journal of Clinical Oncology (2015)

e14579 Background: In the CORRECT phase III trial (NCT01103323), the multikinase inhibitor REG significantly improved overall survival (OS) and PFS vs placebo in pts with mCRC who had disease progression after standard therapies (HR for OS: 0.77; 1-sided p = 0.0052; Grothey, 2013). A post hoc exploratory subgroup analysis was conducted on pts in the REG treatment group who had a PFS longer than 4 months (long PFS). Methods: PFS wasdefined as the time from randomization to disease progression (radiological or clinical) or death from any cause (whichever occurs earlier). Of the505 pts randomized to REG in CORRECT, 98 (19%) were classified as having long PFS benefit, defined as a PFS event > 4 months after randomization. Baseline characteristics, safety, and dosing parameters were analyzed. Results: The long PFS subpopulation was representative of the overall REG-treated population. Long PFS pts received a median of 6 cycles of REG (range 1–12); 92% received ≥ 5 cycles, and 20% had > 8 cycles. Adverse events (AEs) of any grade were experienced by all long PFS pts; the most common grade ≥ 3 AEs were hand–foot skin reaction (20%), hypertension (17%), diarrhea (17%), and fatigue (16%). Conclusions: A subset of 98 (19%) pts treated with REG in the CORRECT study had a PFS > 4 months, confirming the clinical benefit and tolerability of REG as a treatment option for pts with mCRC. Pts with long PFS generally had better ECOG PS (ECOG PS0: 63% vs 52%) and fewer tumor sites (pts with 1 tumor site: 30% vs 19%) than the overall population. Prospective validation of these findings in conjunction with biomarker analysis from real-life clinical experience is needed. Clinical trial information: NCT01103323. All REG pts (n = 505) Long PFS REG pts (n = 98) Median age, yrs (range) 61 (22–82) 61 (34–82) ECOG PS, % 0 1 52 48 63 37 Primary tumor, % Colon Rectum 64 30 52 37 Tumor sites, % 1 2 3 19 36 27 30 38 16 KRASstatus, % Mutant Wild-type 54 41 47 44 Mean treatment duration, months 2.8 ± 2.3* 6.3 ± 2.0 Mean ± SD planned dose, % 78.9 ± 19.9* 81.4 ± 16.3 Mean ± SD daily dose, mg 147.1 ± 18.6* 138.7 ± 22.0 Treatment modifications, % 76* 91 *Treated pts (n = 500)
THE VALUE OF EXPERIMENTAL STUDY OF TRANSPLANTABLE TUMORS.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reproductive and urinary system
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ANTIBODY FORMATION IN CASES OF LOBAR PNEUMONIA TREATED WITH SULFATHIAZOLE
Authors: Yale Kneeland, Barbara Mulliken
Journal: Journal of Clinical Investigation (1940)

Early in 1940'we published a report (1) on antibody formation in cases of lobar pneumonia treated with sulfapyridine.In nineteen treated cases of pneumococcus pneumonia repeatedly studied during the acute phase of the disease and during convalescence, an excess of type-specific antibody was only demonstrated in the serum of four.In the past it has often been shown that spontaneous recovery from lobar pneumonia is associated, in the great majority of instances, with the appearance of an excess of antibody in the patient's serum, and this phenomenon has been generally regarded as an essential part of the mechanism of spontaneously occurring crisis.Our failure to demonstrate antibodies in fifteen out of nineteen cases suggested to us that sulfapyridine had supplanted, at least to some degree, this portion of the immune process.We did not believe that antibody-production ceased to exist in treated cases, but rather that it proceeded at a lower rate, probably because the stimulus to anti-103 March 4 March 6 March 6 00 Hypertensive cardiovascu- P. 80% March 8 00 lar disease.Auricular fi- March 11 00 34 brillation.Some conges- March 13 ++ tive failure.Drug fever March 15 ++ on the tenth day of treat- March 18 + + ment.
From the Centers for Disease Control and Prevention. Recommendations for use of folic acid to reduce number of spina bifida cases and other neural tube defects
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Common Uses of Intravenous Pyelography in Adults
Authors: American College of Physicians*
Journal: Annals of Internal Medicine (1989)

Position Paper1 July 1989Common Uses of Intravenous Pyelography in AdultsAmerican College of Physicians*American College of Physicians*Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-111-1-83 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThis Clinical Efficacy Assessment Project study evaluates the safety, efficacy, and cost of intravenous pyelography in four selected, common applications. The recommendations below are supported by the data analyses shown in the accompanying background paper.Intravenous Pyelography before Prostatectomy for Presumed Benign Prostatic HypertrophyThe historical rationale for theroutineuse of intravenous pyelography before prostatectomy for suspected benign prostatic hypertrophy includes the potential for detecting unsuspected upper tract obstruction to assist in deciding about the need for surgery [3.1, 3.2]; looking for asymptomatic renal or ureteral malignancies [3.1, 3.3]; discovering other unexpected urinary abnormalities (for example, calculi, renal agenesis,... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *This paper was authored by Alvin I. Mushlin, MD; and John R. Thornbury, MD; and was developed for the Health and Public Policy Committee by the Clinical Efficacy Assessment Subcommittee: Paul F. Griner, MD, Chairman; Charles C. Smith, Jr., MD; Paul Calabresi, MD; Lockhart B. McGuire, MD; Earl P. Steinberg, MD; Harold J. Sox, Jr., MD. Members of the Health and Public Policy Committee were: Richard G. Farmer, MD, Chairman; Michael A. Nevins, MD; Charles E. Lewis, MD; Joseph E. Johnson, III, MD; Paul F. Griner, MD; John M. Eisenberg, MD; F. Daniel Duffy, MD; Donald L. Feinstein, MD; C. S. Lewis, Jr., MD; Steven A. Schroeder, MD; Quentin D. Young, MD. This paper was approved by the Board of Regents on 17 June 1988. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1989Volume 111, Issue 1Page: 83-83KeywordsIntravenous pyelographyPrevention, policy, and public healthProstatectomyPublic policyRacial and ethnic issuesSafetySafety studiesSub-specialty careSurgeryYoung adults ePublished: 1 December 2008 Issue Published: 1 July 1989 Copyright & Permissions© 1989 American College of PhysiciansPDF downloadLoading ...
Student-community health projects. How to win friends without influencing people
Authors: R. C. Levy
Journal: JAMA (1972)

Health science students seeking to become involved in community health situations face a variety of problems. The most formidable one relates to establishing rapport with poverty area communities. In the past, students involved in community health projects have often tended to burden local community leaders with more responsibility than they are prepared to handle. Any health science students interested in establishing a community health project should first approach the local leadership with a specific proposal which clearly outlines both student and community responsibilities. The community leadership should be asked to advise student groups during the initial planning stage rather than to control any policy decisions. Once a project is established, the local leadership may assume increasing responsibility in nonmedical policy decisions and serve as a source of both positive and negative feedback.
Surgery
Authors: Arthur E. Baue
Journal: JAMA (1985)

The evolution of topics appearing in CONTEMPO since the first issue reflects the acceleration of increasing specialization in American medicine. This is particularly true in surgery. Whereas in CONTEMPO '78 I attempted to provide the highlights of what was exciting in<i>all</i>areas of surgery, I am now joined by a group of surgical specialists. This year, cardiothoracic surgery, neurosurgery, orthopedic surgery, otolaryngology, plastic surgery, and urology all are separate topics described by members of those specialties. The colon and rectal surgeons may soon have a separate topic heading as well. Surgery as presently constituted in CONTEMPO consists of general surgery, vascular surgery, and pediatric surgery. The importance of surgeons' participation in the diagnosis and care of their patients is increasingly emphasized in the requirements of the American Board of Surgery and by various surgical organizations and committees. Training of surgical residents in endoscopy of the upper and lower gastrointestinal
Lupus Vulgaris
Authors: A. Burrows
Journal: BMJ (1943)

<h3>Abstract</h3> A new phase of the COVID-19 pandemic has started as several SARS-CoV-2 variants are rapidly emerging globally, raising concerns for increased transmissibility. As animal models and traditional <i>in vitro</i> systems may fail to model key aspects of the SARS-CoV-2 replication cycle, representative <i>in vitro</i> systems to assess variants phenotypically are urgently needed. We found that the British variant (clade B.1.1.7), compared to an ancestral SARS-CoV-2 clade B virus, produced higher levels of infectious virus late in infection and had a higher replicative fitness in human airway, alveolar and intestinal organoid models. Our findings unveil human organoids as powerful tools to phenotype viral variants and suggest extended shedding as a correlate of fitness for SARS-CoV-2. <h3>One-Sentence Summary</h3> British SARS-CoV-2 variant (clade B.1.1.7) infects organoids for extended time and has a higher fitness <i>in vitro</i>.
Rescue
Authors: Donna Doyle
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal