tbuckley/cabot-search huggingface dataset:
Diagnostic Imaging of Malignant Melanoma With Radiolabeled Antitumor Antibodies
Authors: Steven M. Larson
Journal: JAMA (1983)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PTU-076 Sucrose intake increases the risk of developing pancreatic cancer: a UK prospective cohort study using data from food diaries
Authors: P J R Banim, R Luben, A McTaggart, N J Wareham, K Khaw, A R Hart
Journal: Gut (2010)

<h3>Introduction</h3> There are plausible biological mechanisms for how excess sucrose intake may initiate pancreatic carcinogenesis via an increased insulin release promoting cell proliferation. The aim of this study was to investigate dietary sucrose intake and the risk of pancreatic cancer, in a prospective cohort study using nutrient data from 7-day food diaries (7-DFDs). <h3>Methods</h3> In EPIC-Norfolk (European Prospective Investigation into Cancer-Norfolk) 25 639 men and women aged 45–74 years were recruited between 1993 and 1997 and completed 7-DFDs. Participants9 sucrose intake was calculated from these diaries using a computer programme containing information on 9000 food items. The cohort was monitored for 16 years to identify those who developed pancreatic cancer. Each case was matched with four controls, for age and gender, and conditional logistic regression used to calculate OR and 95% CI adjusted for smoking, diabetes and total energy intake. To look for threshold effect the OR was calculated comparing the highest quintile of sucrose intake with a combination of the lower four quintiles. <h3>Results</h3> A total of 81 participants (51% men) developed pancreatic cancer (mean age=71.4 years SD=8.6 years) with a median sucrose intake of 44.2 grams per day (range 8.5–140.0 g/day). The highest compared to the lowest quintile intake of sucrose intake doubled the risk of pancreatic cancer, OR 2.27 (95% CI 0.90 to 5.74 p=0.08), with a trend across quintiles OR 1.23 (95% CI 0.99 to 1.53, p=0.07). Comparing the highest intake to a summation of the lowest four levels showed a positive association (OR 1.99, 95% CI 1.05 to 3.78, p=0.04). There was no effect for the intake of total sugars (trend across quintiles OR 0.98, 95% CI 0.77 to 1.26, p=0.90). <h3>Conclusion</h3> The study showed a positive association of an increased sucrose intake with the risk of pancreatic cancer. These epidemiological findings support plausible mechanisms on how excess sucrose may stimulate pancreatic carcinogenesis. Sucrose intake should be accurately measured in future aetiological studies of pancreatic cancer.
Abstract 2614: Distinguished features of ERG oncoprotein expression among matched cohorts of African-American and Caucasian-American prostate cancer patients
Authors: Albert L. Dobi, Philip Rosen, David Pfister, Denise Young, Yongmei Chen, Gyorgy Petrovics, David McLeod, Shiv Srivastava, Isabell Sesterhenn
Journal: Cancer Research (2012)

Abstract Introduction and Objective: The ETS-related gene (ERG) proto-oncogene is frequently overexpressed in prostate cancer (CaP) as a result of a genomic rearrangement that places ERG under the control of the androgen-dependent TMPRSS2 promoter. The initial report of quantitative ERG mRNA expression in micro-dissected prostate tumor cells showed significantly higher ERG expression in CaP of Caucasian-Americans (CA) patients vs. African-American (AA) patients (Petrovics et al, Oncogene, 2005). Recent studies (Magi-Galluzzi et al, Prostate, 2011; Elliott et al, USCAP Mtg., 2011) have also shown higher frequency of ERG rearrangement or ERG oncoprotein expression in CaP of CA patients. We evaluate the frequency and pattern of the ERG oncoprotein expression in prostate tumors of matched CA and AA CaP patients to better understand the biological basis for differences in prostate cancer between the two populations. Methods: Ninety one AA and 91 CA CaP patients were matched for age, Gleason score and pathologic stage. All underwent radical prostatectomy between 1993 and 2010. Whole mount prostate specimens were used for the immunohistochemical detection of the ERG oncoprotein by a highly specific ERG monoclonal antibody (clone 9FY). Individual foci of tumors were reported as either positive or negative. ERG staining data was linked to clinico-pathologic data. Biochemical recurrence was defined as two serum PSA measurements of 0.2 ng/mL or higher at least 8 weeks from surgery. Results: A higher percentage of CA (61.8%) than AA (28.2%) CaP patients had ERG positive index tumors and had at least one focus of tumor positive for ERG. A higher percentage of overall tumor foci were also positive for ERG in CA than AA CaP patients. There was high concordance of ERG positive prostatic intra-epitheilal neoplasia (PIN) and ERG positive CaP in both AA and CA patients. Conclusions: ERG expression is more prevalent among CA than AA CaP patients in matched cohorts. Differences in the pattern of ERG expression in CaP and differing trends in biochemical recurrence between CA and AA patients with ERG (+) index tumors suggest a dominant clonal selection of ERG-positive tumors in CA patients. These differences in ERG expression have the potential to delineate biological distinctions of CaP in the two patient populations. Acknowledgement: This study was supported in part by USU-CPDR and NIH grant CA162383 to SS. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2614. doi:1538-7445.AM2012-2614
Is there a future for community medicine.
Journal: BMJ (1976)

experienced" GPs turned, with each "modu- lation" of the Nuffield "circus," into an exercise in educational methods-fishbowls, role-play, self-assessment, peer assessment, interminable MCQs, MEQs, etc, etc.Each session became an educational exercise in itself-"it's not what you teach-it's the way that you teach it."Surely, training's missed the point if it's not primarily aimed at consumer satisfaction.Not enough is written of what the trainee has learnt or wants to learn and far too much of educational principles, objective evaluation, etc.Methinks, Nuffield supporters, you protest too much.
Abstract 92: Evaluation Of The Ascending Aorta Stifness Following Kawasaki Disease In Compraison With Systemic Hypertension
Authors: Roch Listz Maurice, Ian Nandlall, Anne Fournier, Nagib Dahdah
Journal: Circulation (2015)

Background: Kawasaki Disease (KD) is a systemic vasculitis that affects large and medium-size arteries. The coronary arteries draw most of the clinical attention whereas few studies have taken interest in involvement of other vessels. Using an imaging-based mechanical biomarker (ImBioMark), we measured the ascending aorta (AA) stiffness in pediatric KD subjects compared to healthy controls (CTL) and patients with systemic hypertension (HTN). Methods: We evaluated AA (Fig. 1a) in 20 CTL, 12 KD subjects (4 with and 8 without CA aneurysms). 8 children with HTN represented a comparative clinical model of vascular stiffness. We measured systolic and diastolic AA strains using ImBioMark. Strain was tested for normality against height for CTL. Strain values from KD and HTN subjects were normalized (Z-score) according to height. Comparisons were performed between groups using non-parametric statistics. Results: Systolic and diastolic pressures were normal in KD subjects (49.8±28.4 and 46.1±6.9 percentile, respectively). Age was similar between KD (9.1±5.3 yo) and HTN (9.9±5.3 yo), p=NS. Fig. 1b exhibits a strain curve computed with ImBioMark. Systolic and diastolic strain values were normally distributed against height in CTL. HTN subjects had abnormal systolic and diastolic strain values. KD subjects had normal diastolic strain, but significantly abnormal systolic strain (Fig. 2). There was no statistically significant difference in strain, based on the presence or absence of CA aneurysm. Conclusion: Despite normal blood pressure, AA in KD exhibited reduced strain during systole. This may reflect in situ rigidity of the AA.
Diagnosing streptococcal pharyngitis in patients taking antibiotics
Authors: P. Brunell
Journal: JAMA (1997)

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Tests to be ordered in conjunction with antibiotic use
Journal: JAMA (1977)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ATHREPSIA IN INFANTS
Journal: JAMA (1921)

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Dual Inflow Perfusion for Cardiopulmonary Bypass
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Atlas of Cardioroentgenology
Journal: JAMA (1941)

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Researchers dissect the tick and tock of the human body's master clock
Authors: L. Lamberg
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Isolation of Avian Influenza A(H5N1) Viruses From Humans—Hong Kong, May-December 1997
Journal: JAMA (1998)

A strain of influenza virus that previously was known to infect only birds has been associated with infection and illness in humans in Hong Kong. The first known human case of influenza type A(H5N1) occurred in a 3-year-old child who died from respiratory failure in May 1997. In Hong Kong, the virus initially was identified as influenza type A, but the subtype could not be determined using standard reagents. By August, CDC; the National Influenza Center, Rotterdam, the Netherlands; and the National Institute for Medical Research, London, United Kingdom, had independently identified the virus as influenza A(H5N1). An investigation conducted during August-September by the Hong Kong Department of Health and CDC excluded the possibility of laboratory contamination. Since this initial case was identified, six additional persons in Hong Kong have been confirmed to have influenza A(H5N1) infection, and two possible cases have been identified. This report summarizes the nine cases identified thus far and describes preliminary findings from the ongoing investigation, which indicate that multiple influenza A(H5N1) infections have occurred and that both the source and mode of transmission are uncertain at this time.
Feeding aids.
Authors: M J Connolly, A S Wilson
Journal: BMJ (1990)

Although problems with eating and drinking are not confined to elderly people, 3% ofthose over 65 living at home have difficulties and 2 *4% ofthose over 85 cannot feed independently.' Independent feeding or drinking, or both, may prove difficult for many reasons (box).Some general points are worthy ofemphasis.Firstly, idsabled people often eat slowly; food must be hot to 40-a;,Ai;>*o begin with to remain appetising.Secondly, a table and chair of correct height are vital for maximum comfort and efficiency23; and thirdly, the type of food is as Important as the utensils-for example, soups are difficult for those with tremor and hand held foods.such as sandwiches are easy for hemiplegics or blind
Abstract P005: Lipid Gene Scores and the Incidence of Atrial Fibrillation: The Atherosclerosis Risk in Communities Study
Authors: Faye L Lopez, Pamela L Lutsey, Dan E Arking, James S Pankow, Sunil K Agarwal, Lin Y Chen, Alvaro Alonso
Journal: Circulation (2013)

Background— Recent studies show that lower levels of low density lipoprotein cholesterol (LDLc) and total cholesterol are associated with incident atrial fibrillation (AF), whereas AF is not associated with high density lipoprotein cholesterol (HDLc) and triglycerides. To test a potential causal association between lipid levels and AF risk, we assessed whether previously developed lipid gene scores are associated with the incidence of AF in a large community-based cohort. Methods— Our analysis included 8849 white participants free of AF at baseline (1987-1989) and with lipid gene scores from the ARIC study. We used previously developed phenotype-specific lipid gene scores, based on loci significantly associated with lipid levels. Incidence of AF was ascertained through 2009 from study visit ECGs, and ICD codes from hospitalizations and death certificates. Cox proportional hazards models were used to estimate the hazard ratio (HR) of AF by each respective lipid gene score quintile and per 1 standard deviation (SD) increase of each effect-size weighted lipid gene score. Results— During a median follow-up of 20.7 years, we identified 1207 incident AF cases. The HDLc gene score, the total cholesterol score, and the triglyceride score were not associated with incidence of AF. The continuous LDLc score was not associated with AF overall, but had a significant interaction with gender (p=0.03). A higher LDLc score was associated with a lower incidence of AF in females but not in males (table): multivariable HR and 95% confidence interval (CI) per 1-SD increase: 0.90 (0.83-0.98) vs. 1.03 (0.95-1.11). When the LDLc gene score was split into quintiles, a higher LDLc score for females was associated with a lower AF risk: HR (95% CI) = 0.74 (0.56-0.98) when comparing extreme quintiles (table). Conclusion— In this large population-based study, a higher LDLc score in females was associated with a lower incidence of AF. No association with AF was observed in the LDLc score in males or with the gene scores for HDLc, total cholesterol or triglycerides.
History of Trachoma
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Unprotected left main stenting combined with multivessel PCI: Safety and feasibility. Left main stenting pilot study (Le mans) R. Stefan Kiesz, Pawel Buszman, Jack L. Martin, M. Marius Rozek, Ewa Gaszewska, Janusz Drzewiecki, Michal Tendera. University of Texas Health Science Center, San Antonio, TX, Silesian Medical School, Katowice, Poland
Journal: Journal of the American College of Cardiology (2001)