tbuckley/cabot-search huggingface dataset:
Biochemical and Molecular Epidemiology of Human Cancer: Indicators of Carcinogen Exposure, DNA Damage, and Genetic Predisposition
Authors: Curtis C. Harris, Ainsley Weston, James C. Willey, Glennwood E. Trivers, Dean L. Mann
Journal: Environmental Health Perspectives (1987)

The primary goal of biochemical and molecular epidemiology is to identify individuals at high cancer risk by obtaining evidence of high exposure to carcinogens, leading to pathobiological lesions in target cells, and/or increased oncogenic susceptibility due to either inherited or acquired host factors. This emerging and multidisciplinary area of cancer research combines epidemiological and laboratory approaches. Because DNA is considered to be an important target for modification by mutagens and carcinogens, damage to DNA can be used as an internal, molecular dosimeter of carcinogen exposure. The reactive species of these carcinogens may directly bind to DNA to form adducts and may indirectly cause secondary DNA lesions, e.g., via induction of free radicals and aldehydes. Highly sensitive and specific methods have been developed to measure the minute amounts of DNA lesions and DNA repair products found in biological specimens from humans exposed to carcinogens. For example, DNA adducts have been measured in cells and tissues from people occupationally exposed to carcinogenic polycyclic aromatic hydrocarbons. Antibodies recognizing carcinogen-DNA adducts have also been detected in human sera. Inherited predisposition to cancer has been revealed by recent advances in molecular genetics, including restriction-fragment-length polymorphism. For example, the hypothesis that rare alleles of the Ha-ras proto-oncogene are associated with an increased risk of lung cancer is currently being tested. These approaches afford the potential of biochemical and molecular epidemiology to predict disease risk for individual persons, instead of for populations, and before the onset of clinically evident disease.
PHILADELPHIA LETTER.
Authors: None J. V. S.
Journal: JAMA (1883)

Opening of the Medical Colleges—Our Distintinguished Visitors—The Philadelphia County Medical Society. Philadelphia, Pa., October 23, 1883. On October 1st, about noon, Prof. Alfred Still[ill] delivered the general introductory lecture to the one hundred and eighteenth course of lectures in the Medical Department of the University of Pennsylvania. The speaker was warmly welcomed by a large gathering of eminent members of the profession, many alumni and students, who were amply rewarded by a most excellent address, in which Dr. Stille dwelt to some extent upon higher medical education. In the evening of the same day probably the largest audience that has ever assembled in the arena of Jefferson Medical College Hospital greeted Prof. Theophilus Parvin, who delivered the inaugural address at the opening of the fifty-ninth annual course of lectures of the college. Prof. Parvin spoke in an able and scholarly manner on the " Genius of Medicine." At the conclusion of
AUSTRALIA
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A CENSORSHIP FOR ARTICLES OF THE MATERIA MEDICA.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Two Types of Diets Improve Blood Vessel Function in Men with High Cholesterol
Journal: Annals of Internal Medicine (2001)

Summaries for Patients19 June 2001Two Types of Diets Improve Blood Vessel Function in Men with High CholesterolSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-134-12-200106190-00006 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?High cholesterol levels can lead to blockages in blood vessels, a condition called atherosclerosis. Atherosclerosis can result in heart attacks or strokes when blockages obstruct blood flow to the heart or brain. The endothelium is the lining of blood vessels, and it helps to control their narrowing and expanding. Endothelium that does not function normally plays a role in the development of atherosclerosis. People can lower their cholesterol levels and their chances of developing atherosclerosis by switching from diets high in saturated fats to diets low in saturated ... Author, Article, and Disclosure InformationThe summary below is from the full report titled “Mediterranean and Low-Fat Diets Improve Endothelial Function in Hypercholesterolemic Men.” It is in the 19 June 2001 issue of Annals of Internal Medicine (volume 134, pages 1115-1119). The authors are F Fuentes, J López-Miranda, E Sánchez, F Sánchez, J Paez, E Paz-Rojas, C Marín, P Gómez, J Jimenez-Perepérez, JM Ordovás, and F Pérez-Jiménez.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoMediterranean and Low-Fat Diets Improve Endothelial Function in Hypercholesterolemic Men Francisco Fuentes , José López-Miranda , Elias Sánchez , Francisco Sánchez , José Paez , Elier Paz-Rojas , Carmen Marín , Purificación Gómez , José Jimenez-Perepérez , José M. Ordovás , and Francisco Pérez-Jiménez Metrics 19 June 2001Volume 134, Issue 12 Page: I-15 Keywords Atherosclerosis Blood Blood flow Blood vessels Cholesterol Diet Endothelium Fats Hypercholesterolemia Vasodilation ePublished: 19 June 2001 Issue Published: 19 June 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Effects of Intensive Diabetes Therapy on Neuropsychological Function in Adults in the Diabetes Control and Complications Trial
Journal: Annals of Internal Medicine (1996)

To examine the effect of intensive therapy on neuropsychological performance in patients who participated in the Diabetes Control and Complications Trial (DCCT).Multicenter, randomized, controlled clinical trial.29 DCCT clinical centers.1441 patients with insulin-dependent diabetes mellitus (IDDM) between 13 and 39 years of age who had had IDDM for 1 to 15 years and had no or minimal retinopathy or nephropathy at baseline. Volunteers were excluded if they had a history of substance abuse, psychological disturbance, or recurrent hypoglycemia with coma or seizure.Intensive therapy with 3 or more daily insulin injections or continuous subcutaneous insulin infusion, guided by 4 or more glucose tests per day, compared with conventional therapy with 1 or 2 daily insulin injections.Neuropsychological assessments were done at baseline; years 2, 5, and 7; and the end of the study. Eight cognitive domain scores were developed from the test results and were used to identify patients whose neuropsychological performance had clinically worsened.Intensive therapy did not affect neuropsychological performance. In addition, patients who had repeated episodes of hypoglycemia did not perform differently than patients who did not have repeated episodes.Intensive therapy and the attendant risk for hypoglycemia were not associated with neuropsychological impairment in the DCCT.
Laboratory profile screening in the family physician's office
Authors: T. E. Rardin
Journal: JAMA (1966)

An increase in the use of routine automated laboratory profile screening, included as an essential part of each annual health evaluation, has been predicted and urged by various authorities. Three recent studies indicate 10% of those screened will show some major chemical abnormality. One key specialist in the evaluation of any person's health status is his family physician. This report considers data from a fourth study, consisting of 1,084 consecutive automated laboratory profiles secured on 832 adult patients having health evaluations performed by their family physician. Both patient and physician benefit greatly. The suggestion by many authorities that the apparently healthy person as well as the obviously sick patient be routinely studied by automated laboratory profile screening seems justified.
PHYSIOLOGIC MANIFESTATIONS OF SLEEP
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 12435: The Hypoxic Influence on Right Ventricular Systolic Pressure (RVSP) in the SuHx-model
Authors: Michiel Alexander de Raaf, Ingrid Schalij, Rosa van Amerongen, Frances de Man, Nico Westerhof, Anton Vonk-Noordegraaf, Norbert Voelkel, Harm Jan Bogaard
Journal: Circulation (2012)

Rationale: The SuHx model is based on the combined exposure of rats to the Vascular Endothelial Growth Factor receptor inhibitor SU5416 and hypoxia and has histological features resembling plexogenic pulmonary vascular remodeling in human pulmonary arterial hypertension (PAH). This study aimed to assess vascular reactivity to oxygen exposure in the SuHx model. RVSP was measured continuously by telemetry and the effects were determined of acute exposure to hyperoxic air of previously hypoxic animals. Methods: A telemetry device was inserted using a transdiaphragmatic approach and the tip of the catheter was placed in the right ventricle. To respect the circadian rhythm, data collected between 10 and 11 PM each day was used for analysis. SuHx animals received SU5416 one week after surgery and both SuHx and Hx-only animals were husbanded at 10% inspired oxygen for 4 weeks. Animals underwent echocardiography weekly in an enriched oxygen condition (60%). During the enriched oxygen condition, telemetric RVSP wa...
Medicolegal
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Queries and Minor Notes
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Transactions of the Indiana State Medical Society.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Deaths
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Low Back Pain
Authors: A. W. Squires
Journal: JAMA (1962)

<h3>To the Editor:—</h3> In a recent issue (<i>JAMA</i><b>179</b>:922 [March 17] 1962), a Honolulu physician's inquiries about possible cause and treatment of low back pain with radiation to one lower extremity have been answered quite exhaustively by the consultant. The latter omitted, however, a disorder which not only is extremely common but which also was described quite precisely in the inquiry. For want of any generally recognized term, the condition probably can best be designated "myofascial pain syndrome." Disorders of this sort are among the most common causes of pain and disability of the neck, shoulders, and low back. At the same time, they appear to be among the least understood and most frequently ignored human afflictions. The diagnosis, etiology, and treatment of these syndromes were admirably discussed by Bonica
A NEW DISEASE.
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Infants Tested for Hearing Loss—United States, 1999-2001
Journal: JAMA (2003)

Hearing loss (HL) occurs in one to three of 1,000 live births annually and, when left undetected, can result in developmental delays. To promote communication from birth, Early Hearing Detection and Intervention (EHDI) programs support early identification of infants with HL. Without EHDI programs, the average age of identification for HL is age 1.5-3.0 years, which is past the start of the critical period for optimal language acquisition. In 2001, a total of 48 states/areas with EHDI tracking and surveillance systems (30 funded by CDC) reported the percentage of newborns screened for HL. This report summarizes the results of an analysis of surveillance data for 1999-2001, which indicate that more infants were screened for HL, received diagnostic audiologic evaluations, and were enrolled in early intervention services in 2001 than in 1999 and 2000. Continued development of EHDI surveillance systems should assist states/areas in providing needed services to children with HL.
Medical imaging problems in the patient with advanced cancer
Authors: D. G. Bragg
Journal: JAMA (1980)

THE ROLE of medical imaging, as applied to the patient with advanced cancer, is complex, often costly, and confusing to the non-radiologist-physician. This article sets forth recommendations by body site for medical imaging techniques as applied to the patient with cancer. These are placed in the perspective of cost, specificity, and sensitivity. Institutional variations will exist, depending on operator skill and experience as well as equipment. One of the most frequent reasons for unnecessary radiological procedures in patients with advanced cancer is the clinician's failure to appreciate the metastatic behavior of the tumor when ordering imaging procedures. An additional problem is the understandable frustration of the nonradiological physician with questions concerning which new imaging technique is best or costs the least. A discussion of the behavior of the respective tumors is beyond the scope of this article; however, this information must bias the imaging recommendations in each patient. At the
Cadmium Accumulation and Protein Binding Patterns in Tissues of the Rainbow Trout, Salmo gairdneri
Authors: John Kay, Dafydd G. Thomas, Michael W. Brown, Anthony Cryer, David Shurben, John F. deL. G. Solbe, Justine S. Garvey
Journal: Environmental Health Perspectives (1986)

Rainbow trout were exposed to defined levels of cadmium in their aquarium water for differing periods at a variety of near-lethal concentrations that ensured the survival of the majority of the fish.The gills, liver and kidney together accounted for 99% of the accumulated load of body cadmium in the fish under these conditions.Although the proportion of total cadmium present in the liver remained relatively constant