tbuckley/cabot-search huggingface dataset:
Hypotension and cardiopulmonary arrest associated with concurrent haloperidol and propranolol therapy
Authors: H. E. Alexander
Journal: JAMA (1984)

HALOPERIDOL exerts its antipsychotic effect presumably through potent blockade of central dopamine receptors<sup>1</sup>and has caused hypotension in some patients.<sup>2</sup>Propranolol hydrochloride is a β-adrenergic receptor blocking drug that is widely used in treating hypertension. A review of the literature does not disclose adverse effects in patients from a combination of haloperidol and propranolol. We report herein a patient who had three episodes of hypotension and two episodes of cardiopulmonary arrest after taking concurrent oral doses of haloperidol and propranolol. <h3>Report of a Case</h3> A 48-year-old white woman with a 27-year history of schizophrenia was first admitted to our hospital in 1980. At that time, the patient was treated with haloperidol, 20 mg/day, for an acute exacerbation of her illness. Her symptoms resolved rapidly. The patient was also noted to have hypertension and was treated with a low-sodium diet and with trichlormethiazide, 4 mg/day, which controlled her hypertension. In
Determinants of Polybrominated Biphenyl Serum Decay among Women in the Michigan PBB Cohort
Authors: Heidi Michels Blanck, Michele Marcus, Vicki Hertzberg, Paige E. Tolbert, Carol Rubin, Alden K. Henderson, Rebecca H. Zhang
Journal: Environmental Health Perspectives (2000)

Accidental contamination of the food chain in Michigan in 1973 with polybrominated biphenyls (PBBs) led to the establishment of a registry of exposed individuals in 1976. Serum was collected and analyzed for PBB at the time of enrollment and for targeted studies in the following years. We used the archived PBB data to study the elimination of PBB and to identify factors associated with elimination. A total of 380 women >= 16 years of age who had an initial PBB level of 2 ppb and at least two serum samples drawn when they were not pregnant were included in the analysis. The mean initial PBB level was 20.9 ppb (median 4) and mean time between the first and last measurement was 4.2 years (range 0.5-11.1). PBB was assumed to reach equilibrium in the body before substantial amounts were eliminated and before the first serum measurements were taken; therefore, the entire body was modeled as a single compartment for PBB with exponential decay. Subject-specific decay rate estimates were regressed on predictor variables including initial age, body mass index (BMI), smoking history, breast-feeding duration, and parity. In women with an initial PBB level < 10 ppb, the median half-life was 12.9 years; in those with > 10 ppb, the median half-life was 28.7 years. Decay was significantly slower among women with an initial BMI at or above the median (BMI >= 23). The calculated half-life values are estimates of decay and can be used to estimate body burden of PBB at various points in time other than at the time of serum collection.
News and Notices
Journal: British Journal of Dermatology (1983)

British Journal of DermatologyVolume 109, Issue 2 p. 248-248 News and Notices First published: August 1983 https://doi.org/10.1111/j.1365-2133.1983.tb07094.xAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume109, Issue2August 1983Pages 248-248 RelatedInformation
High grade left atrial spontaneous echo contrast is a potential risk for micro-emboli in cerebral circulation in patients with atrial fibrillation under anticoagulants Yoshio Yamanaka, Hiroya Kawai, Katsuya Hata, Hideyuki Takaoka, Toshiro Shinke, Yoichi Kijima, Takeomi Murata, Soichiro Ota, Yoko Miyata, Yoshiaki Ueda, Ryouhei Yoshikawa, Osamu Iseki, Yasuaki Matsuda, Hozuka Akita, Mitsuhiro Yokoyama. The 1st Dept. of Internal Medicine, Kobe University School of Medicine, Kobe, Japan
Journal: Journal of the American College of Cardiology (2001)
J Thoracic &amp;amp; Cardiovascular Surgery, St. Louis
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Travel Illness Trends Provide Practical Tool for Clinicians
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Vertical transmission of group B Streptococcus. Relation to intrauterine fetal monitoring
Authors: J. P. Davis
Journal: JAMA (1979)

A prospective study of 70 mother-infant pairs was designed to evaluate vertical transmission of group B<i>Streptococcus</i>(GBS) in relation to the use of intrauterine fetal monitors (IUFMs). Multiple-site cultures obtained from mothers during the intrapartum interval and those obtained from infants on day 1 and at discharge or day 4 were plated on a selective medium. Thirteen (27.1%) of 48 IUFM-exposed women vs seven (31.8%) of 22 non-IUFM-exposed women had GBS at one or more sites. The GBS colonization with maternally concordant serotypes occurred in eight (61.5%) of 13 infants born to GBS-colonized, IUFM-exposed women vs two (28.6%) of seven infants born to GBS-colonized, non-IUFM-exposed women. While this suggests that vertical transmission of GBS is enhanced by IUFM placement, the differences in these infant rates were not statistically significant. (<i>JAMA</i>242:42-44, 1979)
Erratum
Journal: CA A Cancer Journal for Clinicians (2002)

Under the heading "The SMOG Readability Formula," the instructions "for text consisting of fewer than 30 sentences" should have read:"1. Count the number of polysyllabic words.2. Calculate the average number of polysyllabic words per sentence.3. Multiply that average number by the number of sentences short of 30."We apologize for this error and any confusion it may have caused.
American Journal of Medical Sciences, Philadelphia
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ugeskrift for Laeger, Copenhagen
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Increasing Influenza Vaccination Rates for Medicare Beneficiaries—Montana and Wyoming, 1994
Journal: JAMA (1995)

Approximately 20,000 influenza-associated deaths occurred during each of 10 different epidemics in the United States during 1972-1991; most (> 90%) of the deaths attributed to pneumonia and influenza occurred among persons aged > or = 65 years. Although Medicare has provided reimbursement for influenza vaccination since 1993, the Health Care Financing Administration (HCFA) received billing claims for influenza vaccination for the 1993-94 and 1994-95 influenza seasons for only 35% and 38% of Medicare beneficiaries, respectively (HCFA, unpublished data, 1995). This report describes the impact of an intervention project in September 1994 in which individual Medicare beneficiaries aged > or = 65 years in Montana and Wyoming were contacted and encouraged to receive influenza vaccination.
Hyperparathyroidism
Authors: Leon Goldman
Journal: JAMA (1974)

This provocative monograph on hyperparathyroidism presents such a unique point of view that an appropriate title should be "Facts, Concepts, and Speculations Regarding Hyperparathyroidism." The text vacillates from solid, proved, established facts to mere speculation in such a manner that the reader might be unaware that the proven substantiation is lacking. The authors report a high incidence of hyperplasia (79%)— with or without adenoma—while they find a single adenoma in only 19%! They imply that normocalcemic hyperparathyroidism, with or without nephrolithiasis, is common. They were led to these conclusions by microscopic examination of parathyroid glands previously considered normal but now deemed hyperplastic. They also cite a high recurrence rate (30%) after the removal of a single adenoma whereas most medical centers report an incidence of 5% or less. They therefore recommend the removal of 3 1/2 parathyroid glands in hyperparathyroidism in order to prevent recurrence. They conclude that the apparently
Immunological Studies on Mice Exposed Subacutely to Methyl Isocyanate
Authors: Anne N. Tucker, John R. Bucher, Dori R. Germolec, Marianne T. Silver, Stephen J. Vore, Michael I. Luster
Journal: Environmental Health Perspectives (1987)

The immunotoxicity of methyl isocyanate (MIC) was evaluated in female B6C3F1 mice exposed via inhalation to 0, 1, or 3 ppm for 6 hr per day on 4 consecutive days. The antibody response to sheep erythrocytes and natural killer cell activity were found to be unaffected by MIC exposure. Although lymphoproliferative responses to mitogens were moderately suppressed by MIC, the differences were not statistically significant. The response of splenic lymphocytes to allogeneic leukocytes in a mixed leukocyte response (MLR) was suppressed in a dose-related fashion and was significantly different from the control response at the 3 ppm level. This effect was thought to be secondary and a result of general toxicity, rather than a direct effect of MIC on the immune system. Furthermore, resistance to the infectious agents Listeria monocytogenes, mouse malaria parasite, and influenza virus, or to transplantable tumor cells was not compromised by MIC exposure. Thus, the immune system does not appear to be a primary target for MIC toxicity.
Puerperal fever with Haemophilus vaginalis septicemia
Authors: C. Regamey
Journal: JAMA (1973)

A small gram-negative pleomorphic rod identified as<i>Haemophilus vaginalis</i>was isolated simultaneously from the blood and the endometrium of an 18-year-old woman with puerperal fever 72 hours after rupture of the membranes and 30 hours after an uncomplicated cesarean section. This organism is fastidious in its growth requirements and slow growing; it can easily be missed in the laboratory.<i>Haemophilus vaginalis</i>is a controversial pathogen of low virulence and has been found mainly in vaginitis. It may be a causative organism of puerperal fever.
Evaluation of Sister Chromatid Exchange and Cytotoxicity in Murine Tissues In Vivo and Lymphocytes In Vitro Following Methyl Isocyanate Exposure
Authors: M. K. Conner, H. F. Rubinson, J. S. Ferguson, M. F. Stock, Y. Alarie
Journal: Environmental Health Perspectives (1987)

The purpose of this study was to assess sister chromatid exchange (SCE) levels and cell cycle kinetics in various murine tissues following MIC exposure. Following exposure of mice to MIC, these parameters were measured in bone marrow and alveolar macrophages labeled with BrdUrd in vivo and in peripheral blood and spleen lymphocytes cultured in the presence of BrdUrd in vitro. Target concentrations of MIC were 2, 15, and 30 ppm (3 hr). Neither elevated SCE frequencies nor inhibition of cell cycling were evident in lipopolysaccharide (LPS)- or concanavalin A (ConA)-stimulated spleen lymphocytes, or in LPS-stimulated peripheral blood lymphocyte (PBL) cultures from mice exposed for 3 hr to MIC concentrations as high as 30.5 ppm. Inhibition of cell cycling and poor culture success rates were apparent in ConA-stimulated PBLs following MIC exposures as low as 2.3 +/- 0.4 ppm for 3 hr. At the lowest MIC dose employed, the cycling characteristics of bone marrow and alveolar macrophages were not altered, and SCE frequencies were at control levels. However, severe cell cycle inhibition was observed in these tissues at MIC concentrations of 15 ppm or greater. A marker of cytotoxicity at this dose was a high frequency (approximately 33-90%) of occurrence of first division cells containing a late-replicating Y chromosome. Despite its apparent cellular toxicity, MIC is not genotoxic as measured by SCE analysis in the tissues examined in this study.
The RET/PTC-RAS-BRAF linear signaling cascade mediates the motile and mitogenic phenotype of thyroid cancer cells
Authors: Rosa Marina Melillo, Maria Domenica Castellone, Valentina Guarino, Valentina De Falco, Anna Maria Cirafici, Giuliana Salvatore, Fiorina Caiazzo, Fulvio Basolo, Riccardo Giannini, Mogens Kruhoffer, Torben Orntoft, Alfredo Fusco, Massimo Santoro
Journal: Journal of Clinical Investigation (2005)

In papillary thyroid carcinomas (PTCs), rearrangements of the RET receptor (RET/PTC) and activating mutations in the BRAF or RAS oncogenes are mutually exclusive. Here we show that the 3 proteins function along a linear oncogenic signaling cascade in which RET/PTC induces RAS-dependent BRAF activation and RAS- and BRAF-dependent ERK activation. Adoptive activation of the RET/PTC-RAS-BRAF axis induced cell proliferation and Matrigel invasion of thyroid follicular cells. Gene expression profiling revealed that the 3 oncogenes activate a common transcriptional program in thyroid cells that includes upregulation of the CXCL1 and CXCL10 chemokines, which in turn stimulate proliferation and invasion. Thus, motile and mitogenic properties are intrinsic to transformed thyroid cells and are governed by an epistatic oncogenic signaling cascade.
β2 integrins are required for skin homing of primed T cells but not for priming naive T cells
Authors: Stephan Grabbe, Georg Varga, Stefan Beissert, Meike Steinert, Gunther Pendl, Stephan Seeliger, Wilhelm Bloch, Thorsten Peters, Thomas Schwarz, Cord Sunderkötter, Karin Scharffetter-Kochanek
Journal: Journal of Clinical Investigation (2002)

β2 integrins are of critical importance for leukocyte extravasation through vascular endothelia and for T cell activation. To elucidate the role of β2 integrins in T cell–mediated immune responses, allergic contact dermatitis (ACD), irritant dermatitis, and delayed-type hypersensitivity (DTH) were assessed in mice lacking the β2 integrin subunit, CD18. ACD and DTH responses, but not edema formation, were severely suppressed in CD18–/– mice. Extravasation of CD18–/– T cells into eczematous skin lesions was greatly impaired, whereas migration of Langerhans cell precursors and dendritic cells was normal in CD18–/– mice. CD18–/–lymph nodes (LNs) contained an abnormal population of CD3–CD44high lymphocytes and showed evidence of widespread T cell activation. T cells from regional LNs of sensitized CD18–/– mice proliferated in response to hapten challenge, and subcutaneous injection of sensitized syngeneic LN cells directly into ears of hapten-challenged naive recipients restored the defective ACD in CD18–/– mice, suggesting that CD18 is not required for priming of naive T cells but is indispensable for T cell extravasation. Thus, a dysfunction of T cells, in addition to granulocytes, may contribute to the pathophysiology of leukocyte adhesion deficiency type I, which arises from mutations in the human CD18 gene.
London, Old and New
Authors: J. R. E.
Journal: Annals of Internal Medicine (1965)

Editorials1 July 1965London, Old and NewJ. R. E.J. R. E.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-1-151 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptLondon is London is London, as Gertrude Stein might say, for it is one of the entrancing cities of the world that seem forever to change and forever to stay the same. The River Thames still pursues its serpentine course from Richmond to Greenwich through the heart of the city just as it has for a millenium and more. The myriad streets great and small still resound without ceasing to the feet and wheels of everyday life and, on occasion, to the pipes and drums of the pagentry of history. Familiar landmarks such as St. Paul's, Trafalgar Square, Big Ben,...Reference1. WOLSTENHOLME G For an illustrated catalogue of this collection see Portraits of the Royal College of Physicians. Edited by , J. and A. Churchill, Ltd., London (distributed by Little, Brown and Co., Boston), 1964. 468 pages. (Reviewed in the July, 1964, issue of the ANNALS). Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByThe Royal College of Physicians of LondonJ. R. E., E. J. H. 1 July 1965Volume 63, Issue 1Page: 151-152KeywordsHeartRivers Issue Published: 1 July 1965 PDF DownloadLoading ...
Abstract 1513: PI3Kγ inhibition activates T cell memory and relieves T cell exhaustion through the reprogramming of tumor-associated macrophages
Authors: Hideyuki Takahashi, Paulina Pathria, Ann Shih, Ryan M. Shepard, Marc A. Paradise, Judith A. Varner
Journal: Cancer Research (2019)

Abstract We previously reported that macrophage PI3-kinase γ (PI3Kγ) controls a critical switch between immune stimulation and suppression during inflammation and cancer. PI3Kγ inhibition repolarizes tumor-associated macrophages, leading to downregulation of immune suppressive factors such as Arginase and IL10 and upregulation of IL12 and other pro-inflammatory cytokines. This results in recruitment and activation of intratumoral CD8+ T cells, as well as induction of immunological memory (Kaneda et al 2016). In the present study, we investigated the effect of PI3Kγ inhibition on T cell immune responses, including T cell memory induction and T cell exhaustion, in mouse models of head and neck squamous cell carcinomas (HNSCC). We found that Pik3cg−/− mice cleared implanted HPV+ HNSCC tumors; when re-challenged with tumor cells, these mice rapidly cleared secondary tumors and remained cancer-free. The proportion of T cells, especially CD8+ T cells, significantly increased in primary tumors from Pik3cg−/− mice. These CD8+ T cells expressed significantly more granzyme B and interferon and less T cell exhaustion markers than T cells from WT animals, indicating that PI3Kγ inhibition in macrophages results in T cell activation. We found that anti-tumor activity was transferable, as adoptive transfer of splenic T cells from Pik3cg−/− mice to naive WT mice suppressed tumor growth. Accordingly, Pik3cg−/− mice with primary or secondary tumors exhibited more splenic CD62L-CD44+ CD8+ effector memory T cells than WT mice. In summary, Pik3cg−/− mice exhibit a more activated T cell immune response and T cell memory than WT mice, resulting significant suppression of tumor growth. These results suggest that PI3Kγ-targeted therapy may activate durable T cell immune responses in patients with HNSCC. Citation Format: Hideyuki Takahashi, Paulina Pathria, Ann Shih, Ryan M. Shepard, Marc A. Paradise, Judith A. Varner. PI3Kγ inhibition activates T cell memory and relieves T cell exhaustion through the reprogramming of tumor-associated macrophages [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1513.