tbuckley/cabot-search huggingface dataset:
Pimento Peppers
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effect of Ethanol on Vinyl Chloride Carcinogenesis
Authors: M. J. Radike, K. L. Stemmer, E. Bingham
Journal: Environmental Health Perspectives (1981)

Four treatment groups (80 male Sprague-Dawley rats/group) were used in a 2 X 2 factorial design: inhalation of 600 ppm vinyl chloride (VC) 4 hr/day, 5 days/week for 1 year; VC and ingestion of 5% ethanol in water (v/v); filtered air and ethanol; filtered air. Ingestion of ethanol was begun 4 weeks prior to inhalation of VC and continued for life or termination of the study at two and one-half years from the first VC exposure. In this model system, ethanol potentiated the carcinogenic response to VC in the liver and produced an excess of neoplasms in animals receiving ethanol alone. Inhalation of VC induced angiosarcoma of the liver in 23% of the exposed animals; ethanol in addition to VC inhalation increased the incidence to 50%. Concomitant administration of VC and ethanol also produced an excess of hepatocellular carcinoma and lymphosarcoma. Ethanol with or without VC had a strong tumorigenic effect on the endocrine system. These results indicate that ethanol is a cocarcinogen in relation to the carcinogen VC.
PDTM-10. NOVEL RNA-TARGETING STRATEGY FOR TREATING T CELL-DRIVEN IMMUNOSUPPRESSION IN HUMAN DIFFUSE INTRINSIC PONTINE GLIOMA
Authors: Alicia Lenzen, Kristen Lauing, Lijie Zhai, Erik Ladomersky, Pichai Raman, Komal Rathi, Rishi Lulla, Rintaro Hashizume, Derek Wainwright
Journal: Neuro-Oncology (2018)

Anaplastic astrocytomas are aggressive cancers of glial cells that present poor prognosis and high recurrence.Heterozygous mutations in IDH1 and IDH2 genes are common in the patients with anaplastic astrocytomas and glioblastomas.In the majority of cases, if not all, the IDH mutations seen in patients with brain tumors have been heterozygous somatic mutations.Patients with Ollier disease and Maffucci syndrome, which are rare enchondromatosis syndromes, have been shown to carry mosaic mutations of IDH1 or IDH2 in non-neoplastic tissues but no patients with anaplastic astrocytoma have been shown to carry such mosaicism.Here, we present two siblings with high grade astrocytoma with IDH1 R132H mutation.Our analysis of IDH1 R132H mutations in the siblings' tumors and nonneoplastic tissues, including healthy regions of the brain, cheek cells and primary teeth has identified IDH1 R132H mosaicism, using digital PCR system.IDH1 R132H mutant allelic frequencies ranging from 0.01% to 0.64% were detected in teeth, cheek cells and non-tumorous brain tissue.The findings were confirmed by next-generation sequencing with similar single nucleotide variation frequencies.Our study demonstrated an example of IDH1 R132H mosaicism in anaplastic astrocytoma patients, which could have gone unnoticed by traditional sequencing technologies.
Wiener Medizinische Wochenschrift
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Incorrect Data in Figures
Authors: Juan Ambrosioni, Mar Mosquera, José Miró, Michael Saag, Huldrych Günthard, Davey Smith
Journal: JAMA (2018)

Jae-Min Kim, MD, PhD; Robert Stewart, MD, FRCPsych; Yong-Seong Lee, MD, MSc; Hee-Joon Lee, MD, BSc; Min Chul Kim, MD, PhD; Ju-Wan Kim, MD, MSc; Hee-Ju Kang, MD, MSc; Kyung-Yeol Bae, MD, PhD; Sung-Wan Kim, MD, PhD; Il-Seon Shin, MD, PhD; Young Joon Hong, MD, PhD; Ju Han Kim, MD, PhD; Youngkeun Ahn, MD, PhD; Myung Ho Jeong, MD, PhD; Jin-Sang Yoon, MD, PhD
Pseudogout mimicking systemic disease
Authors: D. Bong
Journal: JAMA (1981)

Pseudogout is a great mimicker of other forms of arthritis, often leading to diagnostic confusion. The association of pseudogout and fever is less widely recognized. We describe eight patients in whom fever was a prominent manifestation of pseudogout leading to misdiagnosis, overinvestigation, and a delay in appropriate treatment. (<i>JAMA</i>1981;246:1438-1440)
FASs/FASLs ratio: A marker of chemoresistance in advanced colorectal cancer (CRC)
Authors: C. Nadal, J. Maurel, R. Gallego, A. Castells, M. Marmol, S. Sanz, R. Molina, P. Gascon
Journal: Journal of Clinical Oncology (2004)

3583 Background: Oxaliplatin (OXL) or Irinotecan (CPT11)-5-fluorouracil (FU) combinations have improved responses up to 40% in advanced CRC. Unfortunately, those patients who will respond are unknown and, initially sensitive patients become rapidly resistant to current therapies. Fas (CD95) has been implicated in DNA-damage sensitivity. Whereas the pro-apoptotic role of Fas and FasL are well characterized, the function of their soluble forms remains unknown. Methods: We designed a prospective study to evaluate the role of sFas, sFasL and their ratio in CCR chemoresistance. From July 2001 to September 2003, seventy-three patients with advanced CRC(median age= 61; PS 0=25,1=35, 2=13; 1 organ=46; >1=27) received either OXL 85mgr/m2, LV 200 mgr/m2 and FU 3gr/m2, c.i., bi-weekly (group A, n=51) or OXL-FU/CPT11-FU combinations (group B, n=22) in first-line therapy. CT scans were done every 3 months and responses were evaluated by RECIST. ELISA sFas and sFasL analysis were done before treatment and every 3 months, until disease progression. Results: Total extractions, n=179. There were no differences in responses (A=53%, B=46%, p: 0.62). We found a significant increase in sFas levels at 3 m. compared to baseline (13.6 vs 10.2 ng/ml; p=0.001) and a significant increase in the sFasL levels up to 9 m. of therapy compared to 1st-3rd extractions (0.26 vs 0.10 ng/ml; p=0.002). A random effect regression statistical model evaluated the effects of time/therapy on response. We determined that >500 basal sFas/sFasL ratio values and/or a >5 increase in sFas/sFasL ratio were markers of chemosensivity (p=0.014). In addition, we have found a predictor of chemoresistance in a subgroup of patients who despite presenting a high ratio at baseline and a CT response after treatment, they developed decrease ratio. Conclusions: These data strongly indicates that high sFas/sFasL ratio and its increase after treatment could be an excellent marker of chemosensivity in CRC. On the other hand, a decrease ratio after treatment can be a predictor of chemoresistance despite a radiological response. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Grant: “Emili Letang” (Hospital Clinic Barcelona)
Malignancies Occurring during Therapy with Tyrosine Kinase Inhibitors (TKI) for Chronic Myeloid Leukemia (CML) and Other Hematologic Malignancies.
Authors: Dushyant Verma, Hagop M. Kantarjian, Mary Beth Rios, Susan O’Brien, Pat Ault, Elizabeth M. Burton, Zeev Estrov, Gautam Borthakur, Srdan Verstovsek, Guillermo Garcia-Manero, Farhad Ravandi, Jorge Cortes
Journal: Blood (2008)
PROCEEDINGS OF THE MINNEAPOLIS SESSION
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
NOSTRUMS.
Authors: H. C. WOOD
Journal: JAMA (1899)

Very properly, in strict accordance with its etymologic significance, old Dr. Johnson defined nostrum to be "a medicine not yet made public, but remaining in some single hand," but under the present heading I propose to widen out the inquiry of the hour into a more general examination and review of the use in the United States of medicines extrapharmacopeial in their relations, and more or less secret or proprietary in their origin. Time was when the business of pharmacy partook of the nature of a profession, but more and more is the old apothecary shop becoming a mere distributing store, requiring little more scientific knowledge for its management than does the corner grocery. At one time 80 per cent, of the receipts of the druggist were from preparations made or prescriptions compounded in his own laboratory or shop. In 1890, Mr. M. N. Kline made an inquiry based upon
Submucosal Fibrin Adhesion in Upper Gastrointestinal Bleeding
Authors: J. Labenz, U. Peitz, M. Wieczorek, G. Börsch
Journal: Endoscopy (1995)

During the past 15 years, several methods of endoscopic hemostasis have been evaluated in clinical studies for injection therapy with adrenaline/polidocanol. However, these substances may produce tissue damage. In some pilot studies, excellent results concerning initial and definitive control of peptic ulcer hemorrhage were obtained with submucosal injection of a fibrin tissue adhesive.In the past 2½years, 83 patients with upper gastrointestinal (GI) bleeding — peptic ulcer hemorrhage, n = 68 (Forrest I a, n = 16; lb, n =20; II a, n = 29; II b, n = 3); Mallory-Weiss tear, n = 3; varices, n = 3; esophageal ulcer/esophagitis, n = 4; angiodysplasia, n = 2; gastric carcinoma, n = 1; and sphincterotomy bleeding, n = 2 — diagnosed endoscopically were treated with a two-component fibrin adhesive (Tissucol Duo S, Immuno, Heidelberg, Germany) via a double lumen catheter. Initial control of bleeding was achieved in 96.4% (80/83) of patients. Early rebleeding occurred in 11 out of 80 patients (13.8%), which could be effectively managed by repeated injection of the fibrin adhesive in six patients. Nine patients (10.8%) required emergency (n = 5) or elective surgery (n = 4). The overall mortality rate was 6.0%. Complications due to submucosal injection of the fibrin adhesive were not observed.In conclusion, endoscopic submucosal injection of a fibrin adhesive was highly effective (96.4% of patients) in initial control of upper GI hemorrhage predominantly due to peptic ulcer bleeding. By including repeated injections, definitive hemostasis was achieved in 90.4%. Prospective, randomized, and controlled studies are necessary to confirm these encouraging results.KeywordsPeptic UlcerFibrin SealantSubmucosal InjectionEndoscopic HemostasisDouble Lumen CatheterThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Diabetes Mellitus
Authors: Elliott P. Joslin
Journal: New England Journal of Medicine (1946)

Diabetes in ChildrenLichtenstein,49 of Stockholm, has reported his ten years' experience in the treatment of diabetes in children without dietetic restrictions and appends the literature on this method of treatment from Stolte to Tolstoy. Following a review of his article, certain comments that seem pertinent will be given.Lichtenstein has treated diabetic children for thirty-five years, the first fifteen years falling within the pre-insulin era, with its hopeless prognosis; he then changed to the customary strict low-carbohydrate diet and insulin, but gradually adopted a diet richer in carbohydrate but still limited, and for the last ten years he has . . .
Book Review Microbes Which Help or Destroy Us . By Paul W. Allen, Ph.D., D. Frank Holtman, Ph.D., and Louise Allen McBee, M.S. 8°, cloth, 540 pp., with 102 illustrations and 13 color plates. St. Louis: The C. V. Mosby Company, 1941. $3.50.
Journal: New England Journal of Medicine (1942)
Capsule endoscopy in refractory celiac disease
Authors: S. Daum, U. Wahnschaffe, R. Glasenapp, M. Borchert, R. Ullrich, M. Zeitz, S. Faiss
Journal: Endoscopy (2007)

Correction to: Capsule endoscopy in refractory celiac diseaseEndoscopy 2007; 39(05): 455-458DOI: 10.1055/s-2007-966239
Predicting the outcome from hypoxic-ischemic coma: ethical implications
Authors: H. Brody
Journal: JAMA (1986)

<h3>To the Editor.—</h3> Dr Black's editorial<sup>1</sup>on predicting the outcome from hypoxic-ischemic coma correctly notes that predictors of bleak prognosis pose important ethical implications and that some of the key ethical assumptions may remain implicit and unexamined if one moves too quickly from prognostic judgments to public policy decisions. I question, however, his suggestion that a consequentialist analysis lies specifically at the root of any decision that one should withhold life-prolonging treatment from an irreversibly comatose patient. Consequentialist or utilitarian ethics are frequently contrasted to a deontological (rights- or duty-oriented) ethical approach. A fundamental deontological question therefore becomes what is required before one could be said to be the subject of rights and duties (since it is obvious that we should respect the rights of other normal human beings but that we should not worry about respecting the rights of trees and rocks). While opinions differ, one useful line of
Interaction of alkylmercuric compounds with sodium selenite. II. Metabolism of methylmercuric chloride administered alone and in combination with sodium selenite in rats.
Authors: E A Brzeźnicka, J Chmielnicka
Journal: Environmental Health Perspectives (1985)

Repeated doses of sodium selenite (Se) were administered to rats receiving repeated (IV or PO) doses of 0.25 or 2.5 mg Hg/kg methylmercuric chloride (Me2(203)Hg). Se (0.5 mg/kg) was observed to alter the distribution of Me203Hg among tissues as well as among subcellular fractions of kidneys and liver. An excess of selenium resulted in a twofold decrease in the mercury content of kidneys and a similar increase in the mercury content of brain.
Abstract 785: The inhibitory effect of compound ChlA-F onhuman bladder cancer cell invasion can be attributed to its blockage of SOX2 protein
Authors: Xiaohui Hua, Jiheng Xu, Chuanshu Huang, Jingxia Li, Zhongxian Tian, Haishan Huang
Journal: Cancer Research (2019)

Abstract Sex-determining region Y-box 2 (SOX2), a well-known stemness biomarker, is highly expressed in a variety of cancers, including human highly invasive bladder cancer (BC). However, the role of SOX2 may vary in different kinds of malignancy. In the present study, we discovered that ChlA-F, a novel conformation derivative of isolate Cheliensisin A (Chel A), remarkably inhibits the invasive ability of human invasive BC cells through downregulation of SOX2 protein expression. We found that ChlA-F treatment dramatically decreases SOX2 protein expression in human high-grade invasive BC cells. Ectopic expression of SOX2 reversed ChlA-F inhibition of cell invasion ability in human bladder cancer cells, suggesting that SOX2 is a major target of ChlA-F during its inhibition of human BC invasion. Mechanistic studies revealed that SOX2 is downregulated by ChlA-F at both the protein degradation and protein translation levels. Further studies revealed that ChlA-F treatment induces HuR protein expression and that the increased HuR interacts with USP8 mRNA, resulting in elevation of USP8 mRNA stability and protein expression. Elevated USP8 subsequently acts as an E3 ligase to promote SOX2 ubiquitination and protein degradation. We also found that ChlA-F treatment substantially increases c-Jun phosphorylation at Ser63 and Ser73, initiating miR-200c transcription. The increased miR-200c directly binds to the 3’-UTR of SOX2 mRNA to suppress SOX2 protein translation. These results present novel mechanistic insight into understanding SOX2 inhibition upon ChlA-F treatment and provide important information for further exploration of ChlA-F as a new therapeutic compound for the treatment of highly invasive/metastatic human BC patients. Citation Format: Xiaohui Hua, Jiheng Xu, Chuanshu Huang, Jingxia Li, Zhongxian Tian, Haishan Huang. The inhibitory effect of compound ChlA-F onhuman bladder cancer cell invasion can be attributed to its blockage of SOX2 protein [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 785.
Prevention of arteriovenous shunt clotting
Authors: D. Modai
Journal: JAMA (1974)

Two patients on maintenance hemodialysis developed recurrent clotting of an arteriovenous shunt. Anticoagulant therapy was complicated by massive gastrointestinal bleeding. Very small doses of heparin sodium administered into both shunt limbs maintained patency while bleeding ceased. (<i>JAMA</i>230:427-430, 1974)
Supramaximal flow in asthmatic patients
Authors: H. Sala, A. Fernández, S. Guardia, A. González, D. Rodenstein
Journal: European Respiratory Journal (1999)

The use of noninvasive techniques to measure respiratory muscle performance after different types of endurance exercise has not been entirely successful, as the results have not consistently indicated diminished performance for similar types of exercise. The aim of the present study was 1) to compare different, noninvasive methods to assess respiratory muscle performance before and after an exhaustive cycling endurance test (which has previously been shown to induce diaphragmatic fatigue) and 2) to determine which of the tests best reflect published results of measurements of diaphragmatic fatigue. Twelve healthy subjects participated in the study and performed three different test series in a random order on three different days. These tests were performed before, and 5, 40 and 75 min after an exhausting task (a cycling endurance run at 85% of maximal oxygen uptake (V9O2,max)). The tests of the three test series were 1) breathing against a constant inspiratory resistance to task failure, 2) determination of 12-min sustained ventilatory capacity, and 3) spirometric and maximal inspiratory and expiratory mouth pressure measurements. The only measurement that was affected by exhaustive cycling was the time to task failure breathing against inspiratory resistance. It was significantly reduced from (mean+/-sD) 364+/-88 s before exercise to 219+/-122 s at 5 min after cessation of exercise. It is concluded that the constant-load resistive breathing test to task failure is the only noninvasive respiratory muscle performance test evaluated in this study which shows a decrease in respiratory muscle performance after exhaustive endurance exercise.
Myocardial blood flow magnitude is related to cardiac catecholamine uptake-1: A positron emission tomography study in anesthetized dogs Ornella E. Rimoldi, Angela J. Drake-Holland, Marc I. M. Noble, Mohamed Bentourkia, Paolo G. Camici. Medical Research Council, London, United Kingdom, Imperial College School of Medicine, London, United Kingdom
Journal: Journal of the American College of Cardiology (2001)
ANDRE BOCAGE (1892-1953)— FRENCH TOMOGRAPHER
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal