tbuckley/cabot-search huggingface dataset:
Histidinaemia.
Journal: BMJ (1972)

items of a more hopeful and immediately practical nature, though expressed in very guarded terms.Surely there is enough positive evidence that some of these methods have an effect.If results are conflicting there must be a reason for it capable of discovery.It may be possible to improve the composition of oral vaccines, pre- ferably in the first instance by studies in animals: Salmonella infection in mice might permit large-scale work at no great cost.Controlled trials in man on an adequate scale present far greater difficulty, but the undertaking of them in places where typhoid is endemic should be considered.
Erratum: Vol. 65, No. 26
Authors: Kerry Souza, Raoul Guetiya W
Journal: MMWR Morbidity and Mortality Weekly Report (2016)

Venereum Cases Among Men Who Have Sex with Men -Michigan, August 2015-April 2016," on page 920, the first sentence of the third paragraph should have read, "During August 12, 2015-April 30, 2016, MDHHS received 38 reports of LGV all among MSM who were HIV-infected."
Critical Look at Statistical Epidemiology
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Erratum: Post-transplant Kaposi sarcoma originates from the seeding of donor-derived progenitors
Authors: P. Barozzi, M. Luppi, F. Facchetti, C. Mecucci, M. Alù, R. Sarid, V. Rasini, L. Ravazzini, E. Rossi, S. Festa, B. Crescenzi, D.G. Wolf, T.F. Schulz, G. Torelli
Journal: Nature Medicine (2003)
Uncertainty and the future of young physicians
Authors: D. J. Brailer
Journal: JAMA (1986)

Physicians have confronted many recent professional and social challenges, such as rising health care costs, an extensive federal role in health care financing, professional liability, technological growth, and subspecialization.<sup>1-3</sup>Although many physicians have felt threatened, most have adapted to these incremental changes; some have even flourished.<sup>4</sup>Today, however, revolutionary forces such as the physician surplus, the growth of the for-profit sector, competition, and a preoccupation with cost containment threaten to eliminate traditional medical practice, driving even established physicians into alternative delivery systems. For young physicians lacking practice experience and carrying unprecedented debt, the result is overwhelming uncertainty about the future.<sup>5</sup> The article entitled "Health Care in Transition: Consequences for Young Physicians" in this issue of<i>JAMA</i><sup>6</sup>(a report by the American Medical Association's Council on Long-Range Planning and Development) analyzes the forces that make uncertainty part of the modern environment of medicine. Historically, a physician had
Sex and Gender Bias in Illustrations in Anatomy and Physical Diagnosis Texts
Authors: Mark H. Zahniser
Journal: JAMA (1995)

<h3>To the Editor.</h3> —Ms Mendelsohn and colleagues<sup>1</sup>did a nice job of documenting, classifying, and statistically interpreting a large number of anatomical illustrations for this work. However, the authors have not demonstrated any scientific significance to their work, believing, I suspect, that the significance is self-evident. I am writing to say that it is not. The authors make several unsupported and probably unproveable statements in an attempt to justify this study, such as: "This underrepresentation of women in anatomy texts may prevent students from becoming as familiar with the female body as they are with the male body and may create the perception that the male body is 'normal' and the female body 'abnormal.'" The authors also have some rather grandiose ideas regarding the impact of their study as can be seen in their last sentence: "Overcoming text bias could contribute to improving women's health and help bring about
CARDIAC DISTURBANCES AS THE RESULT OF EXHAUSTION.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Advance Directives on Admission Clinical Implications and Analysis of the Patient Self-Determination Act of 1990
Authors: John La Puma
Journal: JAMA (1991)

DESPITE widespread acknowledgment of the need for individuals to draft living wills, durable powers of attorney, or other advance directives, few Americans have done so. To encourage patients to complete advance directives, Congress enacted the Patient Self-Determination Act (hereafter "the Act") last October. The Act takes effect on December 1,1991, and requires hospitals, nursing homes, and hospices to advise patients on admission of their right to accept or refuse medical care and to execute an advance directive. Managed care organizations and home health care agencies must provide the same information to each of their members on members' enrollment. Provider organizations will also be required to (1) document whether patients have advance directives, (2) implement advance directive policies, and (3) educate their staffs and communities about advance directives. Compliance with the Act is a condition for Medicare and Medicaid reimbursement and is tied to institutional
SAT0026 Pro-Resolving and Cartilage-Protective Actions of Resolvin D1 in Inflammatory Arthritis
Authors: L. Norling, S. Headland, J. Dalli, H. Arnardottir, H. Jones, O. Haworth, C. Serhan, M. Perretti
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Dietary supplementation with fish oils has proved efficacious in reducing joint pain, swollen joint count and NSAID usage in RA patients, yet there is an unmet need to determine how they act. Omega-3 PUFA, which are abundant in fish oils are precursors to a new genus of protective bioactive lipids comprised of lipoxins, resolvins, protectins and maresins (collectively termed specialised pro-resolving mediators (SPM)). <h3>Objectives</h3> We hypothesised that SPM may offer a molecular mechanism for the beneficial effects of omega-3 consumption in RA patients. We tested the anti-arthritic potential of a specific SPM; Resolvin D1 (RvD1), in an inflammatory polyarthritis model and investigated novel mechanisms of action. <h3>Methods</h3> Metabololipidomic profiling on murine arthritic joints or human synovial fluids was performed by LC-MS/MS. Murine arthritis was induced by transfer of K/BxN serum. Mice were treated with 100ng AT-RvD1 daily either prophylactically or therapeutically ensuing overt signs of arthritis. Histology and flow cytometry was performed to assess joint leukocyte infiltrate. Human chondrocyte micromasses were cultured to assess chondroprotective actions of RvD1. <h3>Results</h3> Arthritic joints obtained from mice supplemented with an omega-3 rich diet contained elevated levels of protective SPM, and human RA synovial fluid analyses with LC-MS/MS revealed physiologically active levels of RvD1. Mice treated with a stable epimer of RvD1 (17<i>R</i>-RvD1) exhibited significantly attenuated arthritis severity, cachexia, hind-paw oedema and paw leukocyte infiltration and shortened the remission interval. Mechanistically, metabololipidomic profiling in arthritic joints revealed AT-RvD1 significantly reduced LTB<sub>4,</sub> TXB<sub>2</sub> and prostaglandin biosynthesis, whilst selectively enhancing levels of protective SPM. AT-RvD1 stimulated genes associated with cartilage matrix synthesis, exhibited chondroprotection <i>in vitro</i> and direct intra-articular treatment prevented arthritis induced cartilage degradation. Joint protective actions of AT-RvD1 were abolished in ALX <i>(fpr2/3)</i> null mice, indicating the essential role of this receptor in mediating AT-RvD1 actions. <h3>Conclusions</h3> These studies indicate that this SPM offers a valuable therapeutic approach for inflammatory joint diseases including RA. <h3>Acknowledgement</h3> This work was funded by the Arthritis Research UK (Career Development Fellowship 19909 to L.V.N.) and Wellcome Trust Programme grant 086867/Z/08/Z to M.P. This work forms part of the research themes contributing to the translational research portfolio of Barts and the London Cardiovascular Biomedical Research Unit, which is supported and funded by the National Institutes of Health Research. <h3>Disclosure of Interest</h3> None declared
Medical Communications of the Massachusetts Medical Society.
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Exposure to Agent Orange and occurrence of soft-tissue sarcomas or non-Hodgkin lymphomas: an ongoing study in Vietnam
Authors: E Kramárová, M Kogevinas, C T Anh, H D Cau, L C Dai, S D Stellman, D M Parkin
Journal: Environmental Health Perspectives (1998)

Agent Orange was the most common herbicide used in the Second Indochina War in the course of military operations in the former South Vietnam.Agent Orange is contaminated by the carcinogen 2,3,7,8-tetrachlorodibenzo-para-dioxin (TCDD) in mean concentrations of 2 mg/kg.After much dispute of a causal association between exposure to herbicides containing TCDD and occurrence of soft-tissue sarcoma and non-Hodgkin lymphoma, two simultaneous case-control studies were set up in Vietnam to examine possible relationships.Subject recruitment is ongoing, with target numbers of 150 cases of soft-tissue sarcoma and 150 cases of non-Hodgkin lymphoma and diagnoses at the Cancer Center at Ho Chi Minh City, Vietnam.Two hospital controls are matched to each case.As in other studies of cancer in persons occupationally or otherwise exposed to herbicides and their contaminants, evaluation of past exposure of the recruited subjects is among the most complicated issues.Because accurate records are usually unavailable, surrogate measures of likely exposure are often calculated.As a first approach in our studies we used the Stellman and Stellman exposure index.The index is based on matching subjects' history of residence and the information on times and locations of Agent Orange spraying recorded on HERBS tape by the U.S. Army and taking into account the distance from the spraying as well as environmental and biologic half-life of TCDD.The exposure index is calculated in two centers, New York and Hanoi, with slightly different assumptions.In addition, samples of body tissues from the subjects (20 ml blood, 2 g adipose tissue, and tumor sections in paraffin blocks) are taken and stored.Their future analysis will provide additional source of exposure assessment.Strengths and weaknesses of both exposure measures are discussed in this paper.
Saving expressed breast milk
Journal: BMJ (2003)

InfectionLung infection is common after near drowning, especially if brackish water has been aspirated.Embolism of infected material from the lungs to the arterial tree may result in brain abscesses or death from systemic aspergillosis.Blood should be cultured from all patients who have aspirated water.Leptospirosis has been reported after immersion in lakes or reservoirs, possibly due to ingestion of water contaminated with rats' urine.Outpatient follow up with a chest radiography after two weeks is advisable for all patients who have been immersed in water, irrespective of their clinical state on admission. Prognostic signsA blood pH ≤ 7 indicates severe acidosis and is a poor prognostic sign.A low arterial oxygen pressure provides an early indication that water has been inhaled with the attendant risk of pulmonary oedema.The presence of ventricular fibrillation is an adverse sign and responds poorly to defibrillation when the core temperature is below 28°C.The circulation must be supported by chest compression until further attempts can be made when the core temperature has been raised above this level.
Government Services
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cooking With Salmonella
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Role of Protein Kinase C in Regulation of Gene Expression and Relevance to Tumor Promotion
Authors: Mark D. Johnson, Gerard M. Housey, Catherine A. O'Brian, Paul T. Kirschmeier, I. Bernard Weinstein
Journal: Environmental Health Perspectives (1987)

The tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) has highly pleiotropic effects on cells in culture and on tissues in vivo, including effects on protein kinase C (PKC) activation and gene expression. In order to determine the mechanism of activation of gene transcription by TPA, DNA sequences whose transcription is modulated in cells undergoing a mitogenic response to TPA were isolated by differential screening of a cDNA library from TPA-treated cells. TPA-S1 corresponds to an mRNA species whose abundance is increased within 1 hr of exposure of quiescent C3H 10T1/2 mouse embryo fibroblasts. TPA-R1 corresponds to an mRNA species whose abundance is decreased in TPA-treated cells. The induction of TPA-S1 is blocked by actinomycin D and is specific for phorbol esters with tumor-promoting activity. The transcription of this sequence is not induced by cycloheximide, nor is there an enhancement of the TPA response. Several lines of evidence demonstrate that PKC activation plays a critical role in the regulation of TPA-S1 expression. The nucleotide and predicted amino acid sequence of TPA-S1 exhibits homology with sequences representing a peptide with erythroid-potentiating activity, a metalloproteinase inhibitor protein, and a murine protein with beta-interferon-like activity. The role of TPA-S1 in tumor promotion is suggested by the expression of this sequence in mouse skin carcinomas induced by dimethyl-benzanthracene-TPA treatment, but not in papillomas or in control tissue. The consideration of signal transduction pathways may be useful in the design of short-term risk assessment assays for agents that act as tumor promoters.
Functional Recovery in a Friedreich's Ataxia Mouse Model by Frataxin Gene Transfer Using an HSV-1 Amplicon Vector
Authors: Filip Lim, Gloria M Palomo, Christina Mauritz, Alfredo Giménez-Cassina, Belen Illana, Francisco Wandosell, Javier Díaz-Nido
Journal: Molecular Therapy (2007)

There is currently no effective treatment for Friedreich's ataxia (FA), the most common of the hereditary ataxias. The disease is caused by mutations in FRDA that drastically reduce expression levels of the mitochondrial protein frataxin. In FA animal models, a key difficulty is obtaining the precise levels of frataxin expression in the appropriate tissues to provoke pathology without early lethality. To develop strategies to circumvent these problems, conditional frataxin transgenic mice have been generated. We now show that frataxin expression can be eliminated in neurons from these loxP[frda] mice by infection with CRE-expressing herpes simplex virus type 1 (HSV-1) amplicon vectors. We have also achieved in vivo delivery by stereotaxic injection of these CRE-expressing vectors into the brainstem of loxP[frda] mice to generate a localized gene knockout model. These mice develop a behavioral deficit in the rotarod assay detectable after 4 weeks, and when re-injected with HSV-1 amplicon vectors expressing human frataxin complementary DNA (cDNA) exhibit behavioral recovery as early as 4 weeks after the second injection. To the best of our knowledge, this is the first proof of principle of recovery of neurological function by a therapeutic agent aimed at correcting frataxin deficiency. There is currently no effective treatment for Friedreich's ataxia (FA), the most common of the hereditary ataxias. The disease is caused by mutations in FRDA that drastically reduce expression levels of the mitochondrial protein frataxin. In FA animal models, a key difficulty is obtaining the precise levels of frataxin expression in the appropriate tissues to provoke pathology without early lethality. To develop strategies to circumvent these problems, conditional frataxin transgenic mice have been generated. We now show that frataxin expression can be eliminated in neurons from these loxP[frda] mice by infection with CRE-expressing herpes simplex virus type 1 (HSV-1) amplicon vectors. We have also achieved in vivo delivery by stereotaxic injection of these CRE-expressing vectors into the brainstem of loxP[frda] mice to generate a localized gene knockout model. These mice develop a behavioral deficit in the rotarod assay detectable after 4 weeks, and when re-injected with HSV-1 amplicon vectors expressing human frataxin complementary DNA (cDNA) exhibit behavioral recovery as early as 4 weeks after the second injection. To the best of our knowledge, this is the first proof of principle of recovery of neurological function by a therapeutic agent aimed at correcting frataxin deficiency.
“Baseline characteristics of idiopathic pulmonary fibrosis: analysis from the Australian Idiopathic Pulmonary Fibrosis Registry.” Helen E. Jo, Ian Glaspole, Christopher Grainge, Nicole Goh, Peter M.A. Hopkins, Yuben Moodley, Paul N. Reynolds, Sally Chapman, E. Haydn Walters, Christopher Zappala, Heather Allan, Gregory J. Keir, Andrew Hayen, Wendy A. Cooper, Annabelle M. Mahar, Samantha Ellis, Sacha Macansh and Tamera J. Corte.<i>Eur Respir J</i>2017; 49: 1601592.
Authors: Helen Jo, Ian Glaspole, Christopher Grainge, Nicole Goh, Peter Hopkins, Yuben Moodley, Paul Reynolds, Sally Chapman, E Walters, Christopher Zappala, Heather Allan, Gregory Keir, Andrew Hayen, Wendy Cooper, Annabelle Mahar
Journal: European Respiratory Journal (2017)