tbuckley/cabot-search huggingface dataset:
Phase II study of preoperative helical tomotherapy with a simultaneous integrated boost for rectal cancer.
Authors: B. Engels, K. Tournel, H. Everaert, A. Sermeus, G. Storme, D. Verellen, M. De Ridder
Journal: Journal of Clinical Oncology (2011)

537 Background: The addition of concomitant chemotherapy to preoperative radiotherapy is standard of care for patients with T3-4 rectal cancer. The combined treatment modality increases the complete response rate and local control, but has no impact on survival or the incidence of distant metastases. Besides, it is associated with considerable toxicity. As an alternative strategy, we explored prospectively preoperative helical tomotherapy with a simultaneous integrated boost (SIB). Methods: 106 patients were treated with intensity-modulated and image-guided radiotherapy using the Tomotherapy Hi-Art II system. A dose of 46 Gy, in daily fractions of 2 Gy, was delivered to the mesorectum and draining lymph nodes, without concomitant chemotherapy. In patients with a circumferential resection margin (CRM) less than 2 mm on magnetic resonance imaging, a SIB was delivered to the tumor up to a total dose of 55.2 Gy. Acute and late side effects were scored using the NCI-CTC AE v. 3.0. Stage III patients received standard adjuvant chemotherapy. Results: 100 patients (94%) presented with a T3-4 tumor, of which 52 patients entered the boost group (CRM &lt; 2 mm). 54 patients entered the no-boost group. One patient in the no-boost group developed a radiohypersensitivity reaction, resulting in a complete tumor remission, a grade 3 acute and grade 5 late enteritis. No other grade 3+ acute toxicities occurred. With a median follow-up of 32 months (range, 6-58), grade 3+ late gastrointestinal and urinary toxicity was observed in 7 patients (6%) and 4 patients (4%), respectively. Until yet, 2 locoregional relapses were observed. The actuarial 3-year local control, progression-free survival, and overall survival were 97%, 74% and 83%, respectively. Conclusions: Preoperative helical tomotherapy displays a favourable toxicity profile in patients with T3-4 rectal cancer. A SIB can be safely administered in patients with a narrow CRM and results in a promising local control. No significant financial relationships to disclose.
MEDICAL HISTORY ERRORS.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Patient-reported outcomes among people receiving opioid agonist therapy and treatment for hepatitis C virus infection: results from CO-STAR
Authors: Olav Dalgard, Alain Litwin, Gregory Dore, Oren Shibolet, Jason Grebely, Ronald Nahass, Frederick Altice, Brian Conway, Edward Gane, Anne Luetkemeyer, Cheng-Yuan Peng, David Iser, Isaias Noel Gendrano, Michelle M. Kelly, Barbara Haber, Heather Loryn Platt, Amy Puenpatom
Journal: Journal of Hepatology (2020)
Pediatrics
Authors: Hugh A. Carithers
Journal: JAMA (1985)

This attractive book might be characterized as a compromise between a complete textbook and a synopsis of pediatrics. It is much smaller than the most popular textbook in pediatrics, yet has less than half the number of pages. However, it is larger than the fifth edition of Hughes'<i>Synopsis of Pediatrics</i>, but has no more pages. The book is softbound, with two columns to the page, and has many well-composed tables and figures. Adequate references at the end of each chapter are selective and alphabetically presented. Sixty-five authors contributed to the book and skillful editing accomplished a better than usual text in both consistency and clarity of expression. Subjects of a general nature relating to infants and children are presented in a conventional manner, followed by problems encountered in systems and anatomic portions of the body. The chapter "Disorders of Behavior and of Emotional and Cognitive Development" is practical, although
Ethical Considerations of the Left Ventricular Assist Device
Journal: JAMA (1976)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Antenatal diagnosis: what is 'standard?'
Journal: JAMA (1979)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Informed consent.
Authors: J M Bland, D G Altman
Journal: BMJ (1993)

EDITOR,-D D Kerrigan and colleagues report that giving patients detailed information before hernia repair did not significantly increase their anxiety but say that it would help in subsequent litigation.'Although I accept the philosophy behind their conclusion, elective hernia repair is unlikely to give rise to many cases of litigation.Anxiety may be associated with practically every operation.It is doctors' utmost duty to warn of the most serious and most common complications: the Sidaway case in the English courts is a precedent.2Lord Bridge stated that if a complication occurs in more than 10% of cases the patient must be told.In the case of specific risks, such as death, paralysis, and blindness, the patient must also be told even if the risk is less than 1%.This common law, also quoted by the NHS Management Executive's Guide to Consent for Examination or Treatment,3 is not applicable in Kerrigan and colleagues' study: complications do not occur in more than 10% of patients after elective hernia repair, nor are there specific risks of death, paralysis, or blindness.Thus the choice of this procedure for examining consent is not appropriate.The information sheets given to both groups in the study were inadequate and did not satisfy the Department of Health's guidelines3 as they did not mention possible alternatives to elective hernia repair.Doctors should make their own judgment as to how much information each patient needs.There is no point in loading patients with all possible information available.As long as the doctor has
Coloscopie assistée par endocuff est associée avec une réduction du taux d'adénome manqué: une étude tandem randomisée multicentrique.
Journal: Endoscopy (2017)

Le taux de polypes méconnus lors d’une coloscopie reste trop élevé, estimé à 20 %. Parmi les pistes pour améliorer la détection de ces polypes existe l’Endocuff®, instrument qui se fixe en distalité, à l’extérieur du coloscope comme un cap.
A transcriptomic signature predicting fibrosis progression in a large European cohort of patients with histologically characterised NAFLD
Authors: Olivier Govaere, Stuart McPherson, Ramy Younes, Dina Tiniakos, Raluca Pais, Pierre Bedossa, Michael Allison, Marie Boyle, Alastair Burt, Davies Susan, Vian Azzu, Luca Valenti, Jörn M. Schattenberg, Jean-François Dufour, Emmanuel Tsochatzis, Sven Francque, Elisabetta Bugianesi, Chris Day, Ann K. Daly, Vlad Ratziu, Quentin Anstee
Journal: Journal of Hepatology (2020)
Glass Ceiling
Authors: Bhuvana Chandra
Journal: Annals of Internal Medicine (1999)

Ad Libitum21 September 1999Glass CeilingBhuvana Chandra, MDBhuvana Chandra, MDNorthridge, CA 91327 (Chandra)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-131-6-199909210-00008 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail stirring the point of his purple striped tie... Author, Article, and Disclosure InformationAffiliations: Northridge, CA 91327 (Chandra)Corresponding Author: Bhuvana Chandra, MD, PO Box 7694, Northridge, CA 91327. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 21 September 1999Volume 131, Issue 6Page: 437KeywordsBirthHemorrhagePregnancySalivaShouldersVision ePublished: 15 August 2000 Issue Published: 21 September 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Psychoanalysis: waning or waxing?
Authors: A. Poreh
Journal: JAMA (1995)

<h3>In Reply.</h3> —Sexual dysfunction can be induced by several classes of medications, including antihypertensives, antihistamines, antipsychotics, and antidepressants. Much recent attention has focused on the sexual side effects, both detrimental and beneficial, of the selective serotonin reuptake inhibitors. We hope that the following information will help to put recent reports into perspective. The package literature accompanying Prozac (fluoxetine hydrochloride) reports a smaller incidence of sexual dysfunction than those reported in more recent studies or suggested in anecdotal reports. This apparent discrepancy may be related to two factors. First, at the time of product approval, the Food and Drug Administration requires the package insert to contain certain data presented to the agency at the time of submission of the New Drug Application, as well as pertinent updates. The New Drug Application for Prozac was submitted in 1983 and included results of trials conducted through the end of 1982. Adverse drug events
Green hair
Authors: R. M. Lampe
Journal: JAMA (1977)

THE APPEARANCE of green hair in a child is as startling to the parent as it is to the physician. Since current literature has little to say about green hair, we report the following two cases. <h3>Report of Cases</h3><h3>Case 1.—</h3> In a 5-year-old blond girl, progressively increasing green discoloration of her hair developed over one weekend. This followed repeated swimming in a motel pool. The green color was peripheral in distribution and was particularly noticeable in the "ponytail" area (Fig 1). The moistened hair felt silky smooth when passed between the fingers. The green color gradually disappeared when she stopped swimming in that particular pool; this return to normal was aided by daily alternate washing with basic and acidic shampoos, and by careful rinsing and drying the hair after swimming. <h3>Case 2.—</h3> In a 6-year-old blond boy, a similar discoloration developed after he swam repeatedly in a different pool.
Note from the editors: WHO declares international spread of wild poliovirus a public health emergency of international concern
Authors: Collective Eurosurveillance editorial team
Journal: Eurosurveillance (2014)

Preview this article: Note from the editors: WHO declares international spread of wild poliovirus a public health emergency of international concern, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/19/18/art20798-en-1.gif
Aerobic and Anaerobic PCB Biodegradation in the Environment
Authors: Daniel A. Abramowicz
Journal: Environmental Health Perspectives (1995)

Studies have identified two distinct biological processes capable of biotransforming polychlorinated biphenyls (PCBs): aerobic oxidative processes and anaerobic reductive processes.It is now known that these two complementary activities are occurring naturally in the environment.Anaerobic PCB dechlorination, responsible for the conversion of highly chlorinated PCBs to lightly chlorinated ortho-enriched congeners, has been documented extensively in the Hudson River and has been observed at many other sites throughout the world.The products from this anaerobic process are readily degradable by a wide range of aerobic bacteria, and it has now been shown that this process is occurring in surficial sediments in the Hudson River.The widespread anaerobic dechlorination of PCBs that has been observed in many river and marine sediments results in reduction of both the potential risk from and potential exposure to PCBs.The reductions in potential risk include reduced dioxinlike toxicity and reduced carcinogenicity.The reduced PCB exposure realized upon dechlorination is manifested by reduced bioaccumulation in the food chain and by the increased anaerobic degradability of these products.-
Randomized Phase III in Elderly Patients Comparing LV5FU2 with or without Irinotecan for 1st-Line Treatment of Metastatic Colorectal Cancer (FFCD 2001-02)
Authors: E. Mitry, L. Venat-Bouvet, J. Phelip, E. Maillard, J. Jouve, X. Adhoute, D. Gargot, M. Gasmi, L. Bedenne, T. Aparicio
Journal: Annals of Oncology (2012)
Suicide attempt by a 10-year-old after quadruple amputations
Authors: H. L. Resnik
Journal: JAMA (1970)

A 10-year-old boy who underwent quadruple amputation for Waterhouse-Friderichsen's syndrome attempted suicide. The attempt followed a 48-hour period immediately after surgical removal of his last remaining extremity. The failure of attending and house staff to visit and reassure the boy during this time was a direct manifestation of continuous interservice discord concerning the amputations.
Anaphylactic cardiac arrest in a parturient. Response of the newborn
Authors: A. Baraka
Journal: JAMA (1980)

ANAPHYLAXIS is a serious reaction that may follow repeated drug administration. Illustrated here is a fullblown picture of anaphylactic reaction after intravenous induction of anesthesia in a parturient undergoing elective cesarean section. In contrast with the mother in whom cardiac arrest developed, her newborn did not show, at birth, any anaphylactic manifestation. <h3>Report of a Case</h3> A 27-year-old multipara was scheduled for elective, secondary cesarean section because of cephalopelvic disproportion. She was premedicated intramuscularly with atropine sulfate, 0.6 mg. Anesthesia was induced with an intravenous injection of propanidid, 500 mg, which was followed immediately by the development of a generalized rash and edema in the patient. The pulse rate increased from 80 to 160 beats per minute, and the systolic blood pressure dropped from 120 to 40 mm Hg, and was followed within 30 seconds by cardiac arrest. An ECG demonstrated asystole. External cardiac massage and artificial ventilation with 100%
Occupational Cancer in Spain
Authors: Carlos A. Gonzalez, Antonio Agudo
Journal: Environmental Health Perspectives (1999)

The knowledge of specific problems of occupational cancer in Spain is scarce.The environment of the workplace has improved over the last few years after a long period distinguished by bad working conditions, incomplete legislation, and insufficient safety measures and control.It has been estimated that 3,083,479 workers (25.4% of employees) were exposed to carcinogens.The most common occupational exposures to carcinogenic agents were solar radiation, environmental tobacco smoke, silica, and wood dust.The highest number of employees were exposed to silica crystalline (404,729), diesel engine exhaust (274,321), rubber products (99,804), benzene (89,932), ethylene dibromide (81,336), agents used in furniture and cabinet making (72,068), and formaldehyde (71,189).The percentage of total cancer deaths attributed to occupational exposure was 4% (6% in men, 0.9% in women).Compared with other European countries, the incidence of lung cancer and leukemia in Spain are one of the lowest, but it is rapidly increasing.The incidence of urinary bladder and larynx cancer, on the contrary, are one of the highest.Few studies on occupational cancer have been conducted in Spain.The main problems are the availability of death certificates and the quality of the information on occupation in mortality of statistics.It is necessary to improve methods of assessment of exposures using expert hygienists and biologic markers of exposure and diseases.Reduction of cancer by limiting or avoiding exposure to known occupational carcinogens is still necessary.
Powerful anti-colon cancer effect of modified nanoparticle-mediated IL-15 immunogene therapy through activation of the host immune system: Erratum
Authors: Xiaoxiao Liu, Yanyan Li, Xiaodong Sun, Yagmur Muftuoglu, Bilan Wang, Ting Yu, Yuzhu Hu, Lu Ma, Mingli Xiang, Gang Guo, Chao You, Xiang Gao, Yuquan Wei
Journal: Theranostics (2019)

[This corrects the article DOI: 10.7150/thno.24157.].
A phase I dose escalation and pharmacokinetic (PK) study of intravenous aflibercept (VEGF trap) plus docetaxel (D) in patients (pts) with advanced solid tumors: Preliminary results
Authors: N. Isambert, G. Freyer, S. Zanetta, C. Falandry, K. Soussan Lazard, P. Fumoleau
Journal: Journal of Clinical Oncology (2008)

3599 Background: Aflibercept (AF), a potent angiogenesis inhibitor fusion protein, is comprised of human VEGF receptor VEGFR1 (Flt-1) and VEGFR2 (Flk-1) extracellular domains fused to the Fc portion of human IgG1. AF binds and neutralizes all VEGF-A isoforms plus placental growth factor. This study was designed to assess the safety, dose limiting toxicities (DLTs)/ recommended dose (RD) and PK of AF + D. Methods: This phase I study explored escalating doses of AF followed by D (fixed dose 75 mg/m2) every 3 weeks (q3w). A standard 3+3 escalation scheme was utilized. Results: 54 heavily pretreated pts were enrolled (34 in the dose escalation cohort and 20 in the feasibility): 25 male/29 female, median age 57 [37-73], ECOG-PS 0/1: 24/30, with a variety of advanced solid tumors including breast (n=13) and colorectal (n=9). A total of 241 cycles (cy) (median 4, [1-12]) of AF plus D have been administered across 6 AF dose levels (DL) ranging from 2.0 to 9.0 mg/kg. DLTs at cy 1 included: neutropenic infection at 2.0, grade (Gr) 3 dysphonia at 7.0, and uncontrolled hypertension (HTN) at 9.0 mg/kg. The main Gr3-4 AF-related toxicity (% pts) was HTN (15%). Moderate (Gr2) proteinuria (12%) epistaxis (8%) and dysphonia (2%) were observed. Free and bound AF concentrations are comparable to those observed with AF in monotherapy. PK analysis did not reveal any drug-drug interactions. AF 6.0 mg/kg fulfills the criteria for RD: having an excess of free AF at the end of the q3w dosing interval, no DLT and manageable HTN versus highest DLs. Five partial responses (3 breasts, thymoma, thyroid) and 32 stable diseases were noted. Conclusions: AF was safely combined with D with no evidence of exacerbation of D-related toxicities. AF at 6.0 mg/kg + D q3w is the RD.
Case 15-2011: A 19-Year-Old South African Woman with Headache, Fatigue, and Vaginal Discharge
Authors: Madhuri Sopirala, A David, W Leona
Journal: New England Journal of Medicine (2011)

correctionsHe was treated for leprosy with dapsone, clofazimine, and minocycline (for 30 months), with initial progressive sloughing of the leg lesions, leaving ulcerations that healed by secondary intention (Fig. 1C).He remained asymptomatic except for persistent bilateral neuropathic pain in the lower leg that was attributed, in part, to diabetes mellitus.The patient's history of exposure to armadillos years before the development of the acquired immunodeficiency syndrome suggests that HIV-altered cellular immunity probably facilitated subclinical M. leprae infection.With immune reconstitution resulting from highly active antiretroviral therapy, symptomatic borderline tuberculoid leprosy with reversal (type 1) reaction developed in him.Clinicians should consider leprosy in patients receiving treatment for HIV who present with neuralgia, acute edematous, erythematous nodules or tumors, and a history of possible exposure to leprosy, including previous contact with armadillos in the southern United States.