tbuckley/cabot-search huggingface dataset:
Der Balkenmangel
Authors: Mary Jane C. Showers
Journal: JAMA (1969)

Clinicopathologic findings in agenesis of the corpus callosum of the brain are described in detail in this fascinating monograph. To 242 prior case histories the authors add analyses of their own 33 patients. Early symptoms noticeable from infancy to six years of age included seizures, mental retardation, progression in macrocephaly, personality disorders, and headaches. Bones of the skull and appendicular skeleton along with soft tissues of the brain, face, and orbit were frequently the site of malformations. Mental status ranged from normal through all forms of dementia. Confirmed diagnosis depended upon pneumoencephalography and angiography but not electrocephalography. Characteristic changes in the lateral ventricles, third ventricle, and anterior cerebral artery contributed to the differential diagnosis particularly from cystic enlargement of the septum pellucidum. The embryonic development, potential pathogenesis, and comparative anatomy of the great cerebral commissure are competently discussed. The pathophysiology relevant to complex visual functions is similarly presented. The documentation
Etudes neurologiques.
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
HEREDITARY ATAXIA
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Wilfred Trotter
Authors: Ronald A. Malt
Journal: New England Journal of Medicine (1957)

TO write of modern surgery, of neurologic procedures, of neck dissection, of pharyngotomy and laryngectomy, to trace the rise of social psychology or to study the origins of psychoanalysis is inevitably to consider the work of Wilfred Trotter. "An intellect of brilliance outshone in our century by none in medicine, science, and philosophy,"1 Trotter was one of those remarkable men who ranged far outside the boundaries of a specialty to leave an impression on the thought of the ages.1 2 3 4 The art of contemplation was early forced upon him, for, afflicted with spinal disease, he was bed ridden for many of . . .
Modulation of circadian expression of D-site binding protein by the schedule of parenteral nutrition in rat liver
Authors: A Ogawa, M Yano, T Tsujinaka, T Morimoto, S Morita, M Taniguchi, H Shiozaki, K Okamoto, S Sato, M Monden
Journal: Hepatology (1997)

The aim of this study was to investigate the changes in the circadian rhythm of the expression of liver-specific genes caused by different schedules of parenteral nutrition (PN). Rats received PN continuously throughout the day or intermittently during the night or day for 7 days. They were examined for gene expression of D-site binding protein (DBP), albumin, and cytochrome P450 cholesterol 7α-hydroxylase (CYP7) in the liver. The nocturnal PN group showed circadian expression of DBP messenger RNA (mRNA) and protein with a peak at 10 PM, in the same manner as the control rats receiving normal chow feeding. However, the diurnal PN group showed inverted expression of DBP mRNA and protein with a peak at 10 AM. CYP7 mRNA levels exhibited good synchronization with the levels of DBP mRNA in all groups, whereas albumin mRNA levels did not show such synchronization. Gel mobility-shift assay disclosed that the binding activity of the nuclear extracts to the CYP7 gene promoter was changed by the PN schedule in accordance with the expression of CYP7 mRNA. The PN schedule modulates the circadian rhythm of DBP expression and may have an effect on hepatic bile acid formation through transcriptional regulation of the CYP7 gene.
P109 Can A Theory-informed Interactive Animation Increase Intentions To Engage In Physical Activity In Young People With Asthma?
Authors: G. Hoskins, B. Williams, J. Murray, S. Skar, J. McGhee, D. Gauld, G. Brown, S. Treweek, F. Sniehotta, L. Cameron, A. Sheikh, S. Hagen
Journal: Thorax (2014)

<h3>Background</h3> Participation in regular physical activity improves aerobic fitness and well-being. For people with asthma the benefits also include reduced hospital admissions, absenteeism, medication use, and improved ability to cope with the disease. However, although people with asthma can exercise safely, children and young people with asthma are less likely to be physically active than their peers. Integrating the principles of user-centred design and the MRC Framework for Complex interventions a theoretically-informed interactive animation was developed to encourage young people aged 12–18 years with asthma to engage in physical activity. <h3>Methods</h3> A mixed-methods two stage approach was used. In stage 1 a user group (young people with asthma, parents, health professionals) used online consultation and discussion methods to inform the development of the intervention in a highly iterative manner (modelling). The theoretical basis for the intervention was then refined and converted into a 3D animation with accompanying action plan and volitional help sheet. In stage 2 a web-based Interactive Modelling Experiment evaluated effectiveness in three key areas: knowledge about asthma, inhaler use, and intention to increase physical activity. One-to-one interviews and focus groups were used to evaluate the acceptability of the animation and whether the theoretical basis was effective. <h3>Results</h3> Twenty three people were recruited to the user group. Facilitated by multiple online consultation methods the group was highly engaged throughout. Fifty-three individuals were randomised online to receive the intervention or control; 26 completed follow-up questionnaires (49%). The pilot online experiment supported the evidence base for the intervention but demonstrated that recruitment methods and loss to follow-up need addressed before a future trial. Though not powered to detect an effect on intentions and behaviour, the study revealed an impact on intentions to be active (increase) and on safe inhaler use (decrease). Qualitative feedback was positive across all groups, the intervention being well received and regarded as understandable, meaningful, engaging and potentially very useful within an asthma review. <h3>Conclusion</h3> We have developed a high quality, two part intervention regarded as meaningful, acceptable and potentially useful. Future work is needed to establish whether acceptability levels and perceived effectiveness translate into behaviour change.
Technique of Gastric Operations
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE SANITARY MODE OF OATH ADMINISTRATION IN THE COURTS.
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
1169. Preclinical Safety Testing and Biodistribution of a Novel Ribonucleotide Reductase-Defective and Ganciclovir/Aciclovir-Sensitive Recombinant Type I Herpes Simplex Virus (HSV-1) d12.CALPδRR Designed To Target Human Leiomyosarcoma, Gastrointestinal Stromal Tumors, Malignant Fibrous Histiocytoma and Myoma
Journal: Molecular Therapy (2003)
Abstract 11763: Impact of Beta Blockade on Prognosis in Patients With Chronic Severe Degenerative Mitral Regurgitation
Authors: Ofek Y Hai, Nasimullah Khan, Phyllis G Supino, Edmund M Herrold, Clare Hochreiter, Jeffrey S Borer
Journal: Circulation (2014)

Background: The impact of chronic beta blockade (BB) on cardiac events (CE) in patients (pts) with chronic severe mitral regurgitation (MR) has not been studied by randomized trials but is inferred as beneficial from observational data. However a recent randomized preclinical study demonstrated increased mortality with BB in MR. Methods: We retrospectively analyzed 45 consecutive study-eligible pts (age 49±12 yrs, 69% male) with isolated chronic severe non-ischemic MR without concomitant coronary disease, followed through 19 yrs, to assess impact of chronic BB use at entry on CE (death or indications for valve surgery). At entry, all pts were non-hypertensive (HTN) and free of surgical indications; 9 pts chronically received BB at entry (of whom 7 continued receiving BB throughout the study period). CE rate differences were assessed by Kaplan-Meier log rank comparison; 6 pts on non-selective BBs were analyzed separately on an exploratory basis. Cox model analysis was used to adjust for variations in other baseline covariates (age, gender, etiology, other cardiac drugs). Results: During follow-up, CE included: sudden death (1), heart failure (8), a-fib (6), left ventricular (LV) dimensions (IDs)&gt;4.5cm (11), LV ejection fraction (EF)&lt;60% (6), right ventricular (RV) EF&lt;35% (2), combination CE (7). CE risk was 2-fold higher among pts receiving BB (Avg annual risk [AAR]= 15.28%) vs. those not receiving BB (AAR= 33.04%) (p&lt;.05) (Figure). A &gt; 3-fold relative CE risk was observed when pts on selective BB were excluded (AAR: BB vs no BB = 56.18% vs. 15.28%, p=.01). BB effects remained statistically significant (p&lt;.05) when analyses were adjusted for other baseline covariates. Conclusions: Contrary to earlier observational data, in our series BB appears to increase CE risk in pts without HTN. Further research including larger numbers of MR pts, preferably via randomized design, is needed to clarify the discrepancy between the different findings among existing studies.
Ischemic myopathy in uremic hyperparathyroidism
Authors: W. W. Goodhue
Journal: JAMA (1972)

Proximal, painful myopathy during life and complicating hyperparathyroidism secondary to chronic renal failure has been documented histologically only once previously. This patient's unusual, noninflammatory myopathy, with focal calcium deposits, was due to ischemia caused by luminal stenosis in arterioles with circumferential medial calcification and concentric fibrous intimal proliferation.
Incorrect <i>ICD-9</i> Codes and Percentages
Authors: Luke Kim
Journal: JAMA Cardiology (2017)

Luke K. Kim, MD; Rajesh V. Swaminathan, MD; Patrick Looser, MD; Robert M. Minutello, MD; S. Chiu Wong, MD; Geoffrey Bergman, MD; Srihari S. Naidu, MD; Christopher L. F. Gade, MD; Konstantinos Charitakis, MD; Harsimran S. Singh, MD; Dmitriy N. Feldman, MD
Abstracts
Journal: Thorax (1950)

The aim of this work, undertaken at the North-western University Medical School, Chicago, was to find a reliable method for the determination of the so-called voluntary ventilation capacity, that is, the capacity when the subject breathes voluntarily at the maximum rate.The results of the tests were expressed in litres per minute.The procedure was standardized in such a way as to eliminate many factors, such as acapnia, involuntary inhibition of respiration, and individual differences in performance of breathing, which made the results of previous investigators unreliable.In 283 healthy young men and 40 healthy young women the normal values were 167± 21 and 116±21 litres a minute respectively, with reliability coefficients of 0.8 to 0.9.A. I. Suchett-Kaye.
Resident Forum
Authors: David Shulkin
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Training For Required Muscle Action
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The distribution of calcium salt precipitates in the core, periphery and shell of cholesterol, black pigment and brown pigment gallstones
Authors: H Kaufman
Journal: Hepatology (1994)

Calcium bilirubinate, palmitate, carbonate and phosphate have been identified in the cores of cholesterol and pigment gallstones, suggesting a role for precipitated calcium salts in the early events of gallstone formation. Previous studies that compared the calcium salt contents of cholesterol and pigment stones required destruction of gallstone structure. We have used scanning electron microscopy with windowless energy-dispersive x-ray microanalysis to determine the prevalence of calcium salts in a series of cholesterol (n=105), black pigment (n=35) and brown pigment (n=6) gallstones obtained from 146 consecutive patients undergoing cholecystectomy. These techniques provide specific identification of cholesterol and individual calcium salts as they occur within the core, periphery and shell of gallstones without destroying stone structure. Calcium precipitates more than 0.5 μm in diameter can be detected in a cholesterol background at a detection limit of 0.01% by weight. Calcium salts were detected in the centers of 88% of cholesterol and 100% of black (p<0.05 vs. cholesterol) and brown pigment stones. Calcium bilirubinate was identified in the cores of 54% of cholesterol and in all pigment stones (p<0.001 black pigment vs. cholesterol). Calcium palmitate was detected in all brown pigment stones, in 39% of cholesterol stones (p<0.001 vs. brown pigment) and in 31% of black stones (p<0.01 vs. brown pigment). Peripheral calcium salts were detected less in cholesterol (19%) than in black or brown stones (100%, p<0.05). Fourteen percent of cholesterol and black pigment stones were surrounded by shells containing mostly calcium carbonate. The range of stone cholesterol contents (0% to 100%) and frequency of calcium salt precipitates suggest that pigment and cholesterol gallstones represent a spectrum of disease differing more in their peripheral compositions than in their central regions. Cholesterol and pigment gallstones may differ more in growth than in the initial events of stone nidation. (HEPATOLOGY 1994;19:1124–1132.)
Change in physician perspective on cholesterol and heart disease. Results from two national surveys
Authors: B. Schucker
Journal: JAMA (1987)

The National Heart, Lung, and Blood Institute sponsored national telephone surveys of practicing physicians in 1983 (N = 1610) and 1986 (N =1277) to assess attitudes and practices regarding elevated serum cholesterol levels. The 1983 survey was conducted just before the release of the results of the Lipid Research Clinics Coronary Primary Prevention Trial, which showed that a reduction in the blood cholesterol level reduced coronary heart disease. In 1986, 64% of physicians thought that reducing high blood cholesterol levels would have a large effect on heart disease, up considerably from 39% in 1983. Whereas in 1983, physicians attributed considerably less preventive value to reducing the cholesterol level than to reducing blood pressure or smoking, this disparity was substantially smaller in 1986. The median range of blood cholesterol at which diet therapy was initiated was 6.21 to 6.70 mmol/L (240 to 259 mg/dL) in 1986, down from 6.72 to 7.21 mmol/L (260 to 279 mg/dL) in 1983; the median for drug therapy was 7.76 to 8.25 mmol/L (300 to 319 mg/dL) in 1986 and 8.79 to 9.28 mmol/L (340 to 359 mg/dL) in 1983. In 1986, 87% of physicians surveyed felt that medical evidence warranted the recommended treatment levels set forth in the 1984 National Institutes of Health Consensus Conference on Lowering Blood Cholesterol. These changes indicate that by 1986, physicians were more convinced of the benefit of lowering high blood cholesterol levels and were treating patients accordingly. The data also suggest areas for continued educational initiatives. (<i>JAMA</i>1987;258:3521-3526)
A QUEER SURGICAL OVERSIGHT.
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal