tbuckley/cabot-search huggingface dataset:
Phase II trial of sorafenib in esophageal (E) and gastroesophageal junction (GEJ) cancer: Response observed in adenocarcinoma.
Authors: D. Ilson, Y. Y. Janjigian, M. A. Shah, L. H. Tang, D. P. Kelsen, J. Campbell, L. Fuqua
Journal: Journal of Clinical Oncology (2011)

41 Background: Sorafenib is a tyrosine kinase inhibitor targeting VEGFr, PDGFr, Raf and other pathways. Encouraging response and survival were observed in a phase II trial combining sorafenib with chemotherapy in GE cancer (J Clin Oncol 27:2947;2010). We are studying single agent sorafenib in a phase II trial with the primary endpoint to assess progression free survival (PFS). Secondary endpoints include response and therapy tolerance. Methods: Patients (pts) with measurable metastatic E and GEJ cancer with no more than 3 prior chemotherapy regimens were treated with sorafenib 400 mg BID. CT scans were performed monthly for the first 2 months, then every 2 months. Results: Sixteen of 35 pts have been accrued and 14 are currently evaluable. 13 male, 3 female, median KPS 80%, age 58, GEJ 7, E 9, squamous 2, adenocarcinoma (AC)14. An ongoing complete response (11+ months) was observed in a pt with biopsy proven metastatic neck lymphadenopathy (E primary AC, recurrence after prior chemoradiotherapy and surgery). A second pt (GEJ AC) had protracted stable disease in bulky celiac node disease (15+ months). Grade 3 toxicity was limited to skin rash (1 pt), hand foot reaction (1 pt), and fatigue (1 pt). Only 3 of 14 pts (21%) had early disease progression at 2 months or less. Median PFS 4 mos, 4 patients (29%) continue on therapy for more than 7 months. The majority of tumors tested positive for phospho-erk by immunohistochemistry (11/14, 79%). Conclusions: The observation of a durable complete response and protracted stable disease to sorafenib in E cancer is remarkable. Further accrual continues to define PFS. Supported by a grant from Bayer. [Table: see text]
Platelet Mechanotransduction
Authors: Caroline E. Hansen, Yongzhi Qiu, Owen J.T. McCarty, Wilbur A. Lam
Journal: Annual Review of Biomedical Engineering (2018)

The vasculature is a dynamic environment in which blood platelets constantly survey the endothelium for sites of vessel damage. The formation of a mechanically coherent hemostatic plug to prevent blood loss relies on a coordinated series of ligand–receptor interactions governing the recruitment, activation, and aggregation of platelets. The physical biology of each step is distinct in that the recruitment of platelets depends on the mechanosensing of the platelet receptor glycoprotein Ib for the adhesive protein von Willebrand factor, whereas platelet activation and aggregation are responsive to the mechanical forces sensed at adhesive junctions between platelets and at the platelet–matrix interface. Herein we take a biophysical perspective to discuss the current understanding of platelet mechanotransduction as well as the measurement techniques used to quantify the physical biology of platelets in the context of thrombus formation under flow.
GRIPP2 reporting checklists: tools to improve reporting of patient and public involvement in research
Authors: S Staniszewska, J Brett, I Simera, K Seers, C Mockford, S Goodlad, D G Altman, D Moher, R Barber, S Denegri, A Entwistle, P Littlejohns, C Morris, R Suleman, V Thomas, C Tysall
Journal: BMJ (2017)

<b>Background</b> While the patient and public involvement (PPI) evidence base has expanded over the past decade, the quality of reporting within papers is often inconsistent, limiting our understanding of how it works, in what context, for whom, and why. <b>Objective</b> To develop international consensus on the key items to report to enhance the quality, transparency, and consistency of the PPI evidence base. To collaboratively involve patients as research partners at all stages in the development of GRIPP2. <b>Methods</b> The EQUATOR method for developing reporting guidelines was used. The original GRIPP (Guidance for Reporting Involvement of Patients and the Public) checklist was revised, based on updated systematic review evidence. A three round Delphi survey was used to develop consensus on items to be included in the guideline. A subsequent face-to-face meeting produced agreement on items not reaching consensus during the Delphi process. <b>Results</b> 143 participants agreed to participate in round one, with an 86% (123/143) response for round two and a 78% (112/143) response for round three. The Delphi survey identified the need for long form (LF) and short form (SF) versions. GRIPP2-LF includes 34 items on aims, definitions, concepts and theory, methods, stages and nature of involvement, context, capture or measurement of impact, outcomes, economic assessment, and reflections and is suitable for studies where the main focus is PPI. GRIPP2-SF includes five items on aims, methods, results, outcomes, and critical perspective and is suitable for studies where PPI is a secondary focus. <b>Conclusions</b> GRIPP2-LF and GRIPP2-SF represent the first international evidence based, consensus informed guidance for reporting patient and public involvement in research. Both versions of GRIPP2 aim to improve the quality, transparency, and consistency of the international PPI evidence base, to ensure PPI practice is based on the best evidence. In order to encourage its wide dissemination this article is freely accessible on <i>The BMJ</i> and <i>Research Involvement and Engagement</i> journal websites.
Radiology-Pathology
Authors: Jonathan W. Berlin
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Outbreaks of Pneumococcal Pneumonia Among Unvaccinated Residents in Chronic-Care Facilities—Massachusetts, October 1995, Oklahoma, February 1996, and Maryland, May-June 1996
Journal: JAMA (1997)

During October 1995-June 1996, CDC and state and local public health agencies investigated outbreaks of pneumococcal pneumonia with bacteremia at chronic-care facilities (CCFs) serving predominantly elderly populations in Massachusetts, Oklahoma, and Maryland. This report summarizes these investigations and identifies measures that may prevent such outbreaks.
Erythroderma and Erythroblastosis Fetalis
Authors: M. D. Cunningham
Journal: JAMA (1970)

<h3>To the Editor.—</h3> The appearance of a rash during the course of therapy for neonatal hyperbilirubinemia has been recognized.<sup>1,2</sup>The first report associated a macular erythematous rash to the use of phototherapy for the reduction of serum bilirubin. The second report noted the occurrence of a macular erythematous rash as a possible complication following intensive transfusion therapy for severe hemolytic disease of the newborn. No other references relating hyperbilirubinemia and a macular erythroderma could be found in the available literature. This communication further documents our clinical observations of this peculiar skin reaction in four severely affected erythroblastolic infants, none of which were exposed to bilirubin reduction lamps. <h3>Report of Cases.—Case 1.—</h3> A 1.9-kg (4 lb 2 oz) male infant was delivered spontaneously at 33 weeks gestation. He had received three intrauterine transfusions beginning at 28 weeks gestation. The total cord bilirubin value was 4.6 mg/100 ml, and the
J Pharmacol &amp;amp; Exper Therapeutics, Baltimore
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
努南综合征的皮肤病表现
Authors: D. Bessis, J. Miquel, E. Bourrat, C. Chiaverini, F. Morice‐Picard, C. Abadie, F. Manna, C. Baumann, M. Best, P. Blanchet, A.‐C. Bursztejn, Y. Capri, C. Coubes, F. Giuliano, S. Guillaumont, S. Hadj‐Rabia, M.‐L. Jacquemont, C. Jeandel, D. Lacombe, S. Mallet, J. Mazereeuw‐Hautier, N. Molinari, V. Pallure, C. Pernet, N. Philip, L. Pinson, P. Sarda, S. Sigaudy, Y. Vial, M. Willems, D. Genevievé, A. Verloes, H. Cavé
Journal: British Journal of Dermatology (2019)

努南综合征(NS)是一种遗传疾病,患病率高达1‰。它表现为异常面部表情、心脏缺陷和身材矮小。某些拥有NS特征患者还在皮肤上出现大量深棕色小斑点(雀斑),此病症之前称作“豹皮”综合征,但现在称作NS伴多发性雀斑(NSML)。还有一些非典型(异常)“努南样”综合征:此重叠组 RAS 信号通路相关综合征还包括 Costello 综合征和CFC综合症。现在已知约10个影响这类疾病的基因,但不同遗传类型的皮肤病(皮肤)特征尚不明确。因此,这些来自 10 家不同医院的法国医生系统记录了 4 年里在他们的医院就诊的任何NS患者出现的皮肤异常,并将其与NS亚型和基因相关联。在 129 名 9 个月至 77 岁大的患者中,3/4 出现 PTPN11基因突变(改变),其中 65名患者被诊断为NS,34名为NSML。NS患者的皮肤病特征是轻度的、非特异性的,例如,容易擦伤、毛囊凸起(毛发角化病)、皮肤松弛或头发卷曲。NSML患者还出现许多雀斑、更大的棕色斑点,而且通常拥有特殊的 PTPN11 突变。不同基因出现突变的 NS患者更可能拥有显著的皮肤特征,包括头发异常卷曲、眉毛稀疏、显著毛发角化病或多痣。此研究突出显示在遗传性综合征患者中小心进行皮肤病记录的价值。
Announcement
Authors: O. Todarello, M.W. La Pesa, S. Zaka, Klaus Engel, Gertrud Wigand, Ulla-Britt Skatteboe, Svein Friis, Magnhild Kvamsdal Hope, Per Vaglum, Svein Friis, Ulla-Britt Skatteboe, Magnhild Kvamsdal Hope, Per Vaglum, Gabriella Ba, Italo Carta, E. Gillieron, Baruch Spivak, Marguerite Radvan, Richard Ohring, Abraham Weizman, Antony Fernandez, T.G. Sriram, S. Rajkumar, A.N. Chandrasekar, V. Martino, E. Lattanzio
Journal: Psychotherapy and Psychosomatics (1989)
Listerellosis
Authors: Martin M. Kaplan
Journal: New England Journal of Medicine (1945)

LISTERELLOSIS is a sporadic, infectious disease occurring naturally in man1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 and in animals,23 including cattle, sheep, goats, swine, foxes, chickens, rabbits, guinea pigs, gerbils and rats.24 The disease is caused by Listerella monocytogenes (Bergey) and is characterized by symptoms principally referable to the central nervous system.The causative organism, List, monocytogenes, was first submitted as a new species (Bacterium monocytogenes) in 1924 by Murray, Webb and Swann,25 who isolated it from an epizootic affecting their laboratory rabbits and guinea pigs. In 1929, Nyfeldt21 recovered the organism from the blood stream of a seventeen-year-old boy6 with infectious mononucleosis, . . .
Genetic Engineering in Man: Ethical Considerations
Journal: JAMA (1972)

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Index to Council on Drugs' Communications in The Journal
Journal: JAMA (1963)

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ABSTRACTS
Journal: Circulation (1956)

Sound nutrition in the elderly patient differs only slightly from that in the younger adult.A good plan should include fewer calories with a smaller proportion of calories contributed by fat and a larger proportion by protein.Dietary modifications may be necessitated by poor dentures, low income, inadequate cooking facilities, and poor appetite.Moderate activity contributes to the nutrition of the older person by stimulating the circulation, promoting an increased sense of well-being, encouraging an interest in food, and stimulating a sluggish appetite.The elderly obese person is advised to reduce, but this takes convincing because he has lived with his excess weight for a long time. RINZLER
On herds, border guards, and ambulatory infection control
Authors: S. C. Schoenbaum
Journal: JAMA (1985)

Just as all clinicians are aware that on occasion a seemingly simple case can unleash a host of complicated issues, so epidemiologists are aware that a seemingly simple outbreak can raise major theoretical and practical problems. The article in this issue by Remington et al,<sup>1</sup>which describes an outbreak of measles with only four secondary cases, is an example in point. One, and perhaps two, of the four cases would not have occurred had these children been vaccinated against measles at exactly 15 months of age. It is unrealistic to think that all children will be vaccinated precisely on schedule and that may excuse the case that occurred in a 16-month-old, but the case that occurred in an unvaccinated 2 1/2-year-old child has to be considered a failure of preventive medicine. A nationwide immunization program has led to a dramatic reduction in the occurrence of measles in the United
SURGERY OF ONE HUNDRED YEARS AGO.
Journal: JAMA (1897)

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THE HOT SEASON AND CONSEQUENT AILMENTS.
Journal: JAMA (1892)

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Do-not-resuscitate decisions in a community hospital. Incidence, implications, and outcomes
Authors: H. L. Lipton
Journal: JAMA (1986)

To investigate intensity of care after do-not-resuscitate (DNR) designation, the implications of DNR decisions were analyzed in a 450-bed community hospital. All 333 patients who received written DNR orders in a six-month period were studied. These 333 patients constituted 3% of all discharges, but 70% of patients who died in hospital. Treatment goals for care provided after DNR designation were not documented in 60% of the patients' medical records. Intensity of care, as measured by hospital charges, decreased significantly after DNR designation. Although many types of care were provided after DNR, most were noninvasive. These findings suggest that although many DNR policies consider DNR status fully compatible with aggressive care, in actual clinical practice the DNR order usually leads to less intensive care. Results further suggest that the DNR decision should properly become part of a comprehensive patient care plan individualizing treatment goals for patients. (<i>JAMA</i>1986;256:1164-1169)
Serious sequelae of intrauterine contraceptive devices
Authors: G. F. Schwartz
Journal: JAMA (1970)

Although the intrauterine contraceptive device (IUD) has been widely accepted as a safe, convenient means of preventing conception, the use of these devices in their various forms has been attended by complications related both to the type of device and to its insertion. Although most of these complications have been minor, reports of uterine perforations secondary to the use of IUD have been noted. The Surgical Service of the Columbia-Presbyterian Medical Center has encountered three patients with peritonitis or intestinal obstruction or both resulting from displaced IUDs. These seriously ill patients form the basis of this report and experiences with them lead to the conclusion that the discovery of an intraperitoneal IUD, despite the absence of symptoms, is sufficient reason for its elective removal.
POLLUTED WATER AND EPIDEMIC DIARRHEA.
Journal: JAMA (1907)

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Error in Figure.
Journal: JAMA (1995)

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