tbuckley/cabot-search huggingface dataset:
Smashed Pots
Authors: Jack Coulehan
Journal: Annals of Internal Medicine (2009)

On Being a Doctor5 May 2009Smashed PotsJack Coulehan, MD, MPHJack Coulehan, MD, MPHFrom the State University of New York at Stony Brook, Stony Brook, NY 11794-8036.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-150-9-200905050-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail This is a tale about restitution. From a moral perspective, I think most of us would agree that we ought to return things that we'e stolen to their rightful owner. But what if the objects at issue have no aesthetic or economic value, and the people you took them from have been dead for several hundred years? Let me pose the question more precisely: Is it morally required to return pottery fragments that you'e taken from an ancient garbage heap? And if, in fact, such a duty exists, just how much effort does a good conscience require of us?For ... Author, Article, and Disclosure InformationAffiliations: From the State University of New York at Stony Brook, Stony Brook, NY 11794-8036.Corresponding Author: Jack Coulehan, MD, MPH, Department of Preventive Medicine, HSC L3-086, State University of New York at Stony Brook, Stony Brook, NY 11794-8036; e-mail, [email protected]cc.sunysb.edu. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 5 May 2009Volume 150, Issue 9Page: 650-651KeywordsConsciousnessCrimeCyclic adenosine monophosphateEmotionsHealth care facilitiesHospitalsMeatMedical servicesPreventive medicineRivers ePublished: 5 May 2009 Issue Published: 5 May 2009 Copyright & PermissionsCopyright © 2009 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
ECG Challenge: March 29, 2016
Authors: Philip Podrid
Journal: Circulation (2016)

ECG Challenge 1296An 80-year-old woman with a history of hypertension being treated with amlodipine and a β-blocker presents to her primary care physician for a routine physical examination.Her blood pressure is controlled, and her physical examination is unremarkable.Her pulse is noted to be slow, and a 12-lead ECG is obtained.
Why don’t people with psoriasis take enough exercise?
Journal: British Journal of Dermatology (2020)

Psoriasis is a chronic skin condition which causes red, scaly patches and affects around 2% of the population. People with psoriasis are more likely than others to suffer cardiovascular disease (e.g. heart attack or stroke). It is well known that regular physical exercise reduces the risk of cardiovascular disease, but, worryingly, people with psoriasis take less exercise than most people.
<i>Circulation: Cardiovascular Interventions</i> Editors' Picks
Journal: Circulation (2012)

The following articles are being highlighted as part of Circulation's Topic Review series. This series summarizes the most important manuscripts, as selected by the editors, published in Circulation and the Circulation subspecialty journals. The studies included in this article represent the Editors' Picks for each Circulation: Cardiovascular Interventions' issue published in 2011.
Society News.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ringworm in the Light of Recent Research.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
B.M.A. Annual Meeting, Manchester (continued): Panel Discussion: Do We Spend Enough on Drugs?
Journal: BMJ (1964)

3) " Continuing Care in Chronic Disease," (4) " The Next Ten Years," (5) " What Are the Teachers Thinking?"Below we print a further instalment of the Scientific Proceedings.The first instalment appeared last week (I August, pp.301-8).Continuing Care in Chronic Disease (Contd.)Panel Discussion : "Do We Spend Enough on Drugs ?"Wednesday, 22 7uly
Error in Figure
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Official Call
Journal: JAMA (1977)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Specialty Abstracts
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hospital inquires.
Authors: A J Akhtar
Journal: BMJ (1978)

receptor content to equal extent but has a larger effect on rapidly proliferating cells than on slowly growing cells.'Recent data show that receptor-negative human breast cancers generally have a higher growth rate, as indicated by a higher labelling index and mitotic index.6The conclusions by Lipmann et al may therefore have to be amplified to state that human breast cancers with low oestrogen receptor content usually are the more rapidly growing tumours and consequently are relatively more sensitive to cytostatic treatment.
Anal Cancer: The Case for Earlier Diagnosis
Authors: A T Edwards, L C Morus, M E Foster, G H Griffith
Journal: Journal of the Royal Society of Medicine (1991)

The results of treatment in 22 patients with anal carcinoma are reviewed. The overall results are disappointing with only five (28%) surviving more than 5 years. The commonest form of treatment during the study period was an abdomino-perineal excision of rectum (APER). For patients with tumours less than 2 cm in diameter local excision is an acceptable alternative. The majority (76%) of tumours were diagnosed as common benign conditions by the referring practitioners leading to a delay in initiating definitive treatment. Most tumours (81%) were greater than 2 cm in diameter and therefore unsuitable for local excision. There was a high recurrence rate (76%) amongst the group treated by APER. This along with the poor overall survival is probably due to late presentation.
Increase in the Blood Pressure of Rats Chronically Fed Low Levels of Lead
Authors: H. Mitchell Perry, Margaret W. Erlanger, Elizabeth F. Perry
Journal: Environmental Health Perspectives (1988)

Groups of 15 to 18 female weanling Long-Evans rats fed a rye-based diet low in lead (0.25 ppm) were exposed to 0.1, 1.0, and 5.0 ppm lead in drinking water. No suggestion of clinical lead toxicity was recognized. Systolic pressures were measured at 3-month intervals after weaning. The groups of lead-exposed animals had consistently and significantly higher average pressures than control animals, the increase approximating 15 mm Hg. With the lowest lead exposure (0.1 ppm), the increase in average pressure was gradual, being half minimal at 3 months and requiring 1 year to become maximal. After 1 year, half of these rats had pressures from 0 to 10 mm Hg above the control average; 40, 20, and 10% had pressures that were 20, 30, and 40 mm Hg, respectively, above the control average. Thus, rats exposed to lead in amounts comparable to the environmental exposure of many Americans had an average elevation in systolic pressure comparable to that of human beings with essential hypertension.
NRG BR002: A phase IIR/III trial of standard of care therapy with or without stereotactic body radiotherapy (SBRT) and/or surgical ablation for newly oligometastatic breast cancer.
Authors: Steven J. Chmura, Kathryn A. Winter, Joseph Kamel Salama, Wendy A. Woodward, Virginia F. Borges, Hania A Al-Hallaq, Martha Matuszak, Nora T. Jaskowiak, Michael T. Milano, Hanna Bandos, Julia R. White
Journal: Journal of Clinical Oncology (2015)

TPS1105 Background: This is a randomized Phase II trial to evaluate if stereotactic body radiotherapy (SBRT) and/or surgical resection (SR) of all metastatic sites in oligo-metastatic breast cancer who have received up to 6 months of first line systemic therapy without progression will significantly improve median progression free survival (PFS). If this aim is met the trial continues as a phase III to evaluate if SBRT/SR improves 5 year overall survival (OS). Secondary aims include local control in the metastatic site, distant metastatic rate, and technical quality. Translational primary endpoint is to determine whether < 5 CTCs is an independent prognostic marker for improved PFS and OS. Predictive value of CTCs will be assessed. Methods: Women with pathologically confirmed metastatic breast cancer to < / = 2 sites who have received up to 6 months of standard first line systemic therapy and the primary site disease is controlled are eligible. CNS metastases are ineligible. ER/PR and HER-2 neu is required on the primary or metastatic site. Site radiation credentialing with a facility questionnaire and a case benchmark is required. Randomization is to local radiotherapy/ surgery for palliation only when necessary versus ablation of all metastases with SBRT and/or SR. Statistics: For the phase IIR portion to detect a signal for improved median PFS from 10.5 to 19 months with 95% power and accounting for ineligible/lost patients, 146 patients will be required. For the Phase III, an additional 246 patients will be required to definitively determine if ablative therapy improves 5-year OS from 28% to 42.5% (HR = 0.67), with 85% power and a one-sided type I error of 0.025. For the translational research, the number of patients accrued in Phase IIR and Phase III portions will provide sufficient power of at least 91% to detect whether < 5 CTC’s is a prognostic marker for improved PFS and OS. Contact Information: Protocol: CTSU member web site https://www.ctsu.org. Pt enrollment: OPEN at https://open.ctsu.orgor the OPEN tab on CTSU member web site. Support: NCI U10CA180868 and U10CA180822 Clinical trial information: Pending.
Pulmonary medicine
Authors: W. R. Barclay
Journal: JAMA (1979)

In recent years advances in the field of pulmonary medicine have resulted either from more sophisticated techniques to measure pulmonary function or from the use of fiberoptics combined with radiology to visualize better and to perform selectively biopsies of lung tissue. These techniques have increased diagnostic accuracy and have led to clearer perceptions of the relationship between lung structure and function. However, in 1978 infectious disease problems commanded the attention of pulmonologists and resulted in the description of a newly recognized entity, Legionnaires' disease,<sup>1</sup>and the marketing of a vaccine against a disease long recognized, pneumococcal pneumonia.<sup>2</sup> <h3>Legionnaires' Disease</h3> Legionnaires' disease, in which the primary organ of attack is the lung, was at first of uncertain origin. Several theories were proposed, including a bacterial infection, a virus infection, an allergic reaction, and a toxin,<sup>3</sup>as possible causes. Finally McDade et al<sup>4</sup>isolated the causative organism by
Gastroenterology
Authors: Charles G. Moertel
Journal: JAMA (1974)

The multifaceted and frequently controversial problems of gastrointestinal disease present a formidable challenge to anyone so bold as to undertake the composition of a gastroenterology textbook. Previous efforts have frequently fallen short of the needs of large groups of readers.<i>Gastroenterology</i>by Bockus is recognized as the classic in this field, but its huge volumes represent overkill for the requirements of the average medical resident or practicing physician. An alternative, the smaller, single-authored text, frequently provides only a narrow and opinionated view of this very broad landscape.<i>Gastroenterology</i>by Dr. Bogoch and his associates rests in a comfortable middle ground between these extremes and can easily find a place in the libraries of the internist, general surgeon, and family physician. The book has five major subdivisions. The first is, in essence, devoted to the performance and evaluation of the medical history and physical examination in the patient with gastrointestinal disease.
Leukemia—Disturbance of Regulation?
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Genes and environment determine survival in familial hypercholesterolaemia
Journal: BMJ (2001)

Genes and environment determine survival in familial hypercholesterolaemiaThe risk of early death and premature cardiovascular disease in familial hypercholesterolaemia may have been overestimated because previous studies have looked only at patients and families who sought medical attention.Sijbrands et al (p 1019) traced all members of a Dutch pedigree dating from 1800 to 1989 and calculated their risk of death.They found that many untreated patients had normal life spans.The variation in mortality, they conclude, suggests that outcome is determined by complex interaction between genetic and environmental factors.This card is fiction but some think that predictive testing for common diseases may not be far off
Decreased Sialidase Activity in Alveolar Macrophages of Guinea Pigs Exposed to Coal Mine Dust
Authors: Helene Terzidis-Trabelsi, Jean Pierre Lefevre, Jean Bignon, Claude R. Lambre
Journal: Environmental Health Perspectives (1992)

The origin of immune dysfunctions that are observed in pneumoconiotic miners still remains unknown. There is evidence that the carbohydrate moiety of membrane glycoconjugates is of primary importance in many functions of immunocompetent cells. The glycosylation, and especially the sialylation level of membrane components of various lymphocyte and macrophage subsets, vary depending on the state of cellular differentiation and activation. Sialidases, which may regulate the amount of sialic acids exposed on the cell membrane, can thus be considered as immunoregulatory enzymes. In this report, the sialidase activity has been measured in alveolar macrophages (AM) and in cell-free bronchoalveolar lavage fluid (BALF) from guinea pigs exposed for 4 months to coal mine dust at a concentration of 300 mg/m3. The samples were collected by bronchoalveolar lavage 2 months after cessation of exposure. The sialidase activity in the cell-free fluid and in the purified alveolar macrophages showed a 10-fold decrease (p less than 0.001). Kinetic parameters of the enzyme such as Km and optimum pH did not change. This changed activity was specific for sialidase, as two other lysosomal glycosidases, beta-galactosidase and N-acetylglucosaminidase, showed unchanged activities. These results suggest the possibility that, by inducing a decreased sialidase activity, exposure to coal mine dust may lead to a modified expression of AM membrane-associated sialic acids giving rise to altered immune functions (i. e., phagocytosis, antigen processing, response to cytokines, etc.).
SELECTIONS.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
New Names
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal