tbuckley/cabot-search huggingface dataset:
Schistosomiasis and Praziquantel
Authors: Z. FARID
Journal: Annals of Internal Medicine (1983)

Letters and Corrections1 December 1983Schistosomiasis and PraziquantelZ. FARID, M.D., C.K. WALLACE, M.D.Z. FARID, M.D.Search for more papers by this author, C.K. WALLACE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-99-6-883_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We read with interest the article on praziquantel in the August issue of the Annals (1) and would like to stress several points. In on-going clinical studies at this center, we have found praziquantel, in a single oral dose of 30 mg/kg body weight, to be highly effective against Schistosoma haematobium; 20 of 31 children (mean age, 13 years) were cured with no live eggs in urine 3 months after treatment. There were no toxic side effects except transient headaches and mild gastrointestinal discomfort. Our results agree with those of other reports (2, 3).Treatment ofS....References1. PEARSON R and GUERRANT R. Praziquantel: a major advance in anthelmintic therapy. Ann Intern Med. 1983;99:195-8. LinkGoogle Scholar2. DAVIS A, BILES J, and ULRICH A. Initial experiences with praziquantel in the treatment of human infections due to Schistosoma haematobium. Bull WHO. 1979;57:773-9. MedlineGoogle Scholar3. KARDAMAN M, AMIN M, FENWICK A, CHEESMOND A, and DIXON H. A field trial using praziquantel (Biltricide) to treat Schistosoma mansoni and Schistosoma haematobium infection in Gezira Sudan. Ann Trop Med Parasitol. 1983;77:297-304. CrossrefMedlineGoogle Scholar4. KILPATRICK M, EL-MASRY N, BASSILY S, and FARID Z. Oxamniquine versus niridazole for treatment of uncomplicated Schistosoma mansoni infection. Am J Trop Med Hyg. 1982;31:1164-7. CrossrefMedlineGoogle Scholar5. SANTOS A, BLAS B, and NOSENAS J. Preliminary clinical trials with praziquantel in Schistosoma japonicum in the Philippines. Bull WHO. 1979;57:793-9. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Z. FARID, M.D.; C.K. WALLACE, M.D.Affiliations: U.S. Naval Medical Research Unit No. 3 Cairo, Egypt PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCombined praziquantel-oxamniquine treatment of schistosomiasisSchistosomiasis and PraziquantelZ. FARID, M.D., B. TRABOLSI, M.D., M. STEK, M.D. 1 December 1983Volume 99, Issue 6Page: 883-883KeywordsBody weightChildrenSchistosomiasisUrine ePublished: 1 December 2008 Issue Published: 1 December 1983 PDF downloadLoading ...
Abstract 2938: Decrease in Endocardial Radial Strain Precedes Global Left Ventricular Dysfunction in Patients With Hypertension.
Authors: Kazuhisa Nishimura, Hideki Okayama, Makoto Saito, Toyofumi Yoshii, Katsuji Inoue, Go Hiasa, Takumi Sumimoto, Akira Kurata, Jun Suzuki, Akiyoshi Ogimoto, Tomoaki Ohtsuka, Jitsuo Higaki
Journal: Circulation (2007)

Background: Recent studies have reported that endocardial radial strain was approximately two fold greater than epicardial strain in normal subjects. Hypertension is a major cause of myocardial dysfunction and heart failure, but the difference between endocardial and epicardial radial strain in patients with hypertension is unknown. Two-dimensional speckle tracking echocardiography is a novel echocardiographic method that enables angle-independent assessment. Aim: The aim of this study was to evaluate the difference between radial strain in endocardial and epicardial segments in hypertensive patients. Method: This study enrolled 37 patients with hypertension (H group, age 63±12years, 24men) and 17 sex- and age-matched normal subjects (N group, age 61±7 years, 9 men). Conventional echocardiography was performed by a Vivid 7 dimension (GE). Endocardial and epicardial radial strains were calculated from the left ventricular (LV) short axis view at the papillary muscle level using custom software (EchoPAC (GE)). Results: There were no significant differences in LV diastolic dimension (47±5 mm vs. 48±4 mm), LV systolic dimension (29±4 mm vs. 29±4 mm), LV ejection fraction (65±9% vs. 67±6%) and fractional shortening (38±5% vs. 39±5%) between the H and N group. LV mass index (LVMI) in the H group was significantly greater than in the N group (109±33g/m2 vs. 90±22g/m2, P&lt;0.05). Global radial strain including endocardium and epicardium were not significantly different between the H and N group (59±20% vs. 62±17%). However, endocardial radial strain in the H group was significantly less than in the N group (48±24% vs. 62±15%, P=0.03), whereas there was no significant difference in epicardial radial strain between the two groups (38±16% vs. 28±10%). The ratio of endocardial to epicardial radial strain (Endo/Epi ratio) in the H group was significantly smaller than in the N group (1.5±1.1 vs. 2.4±1.1, P&lt;0.01). There were significant correlations between End/Epi ratio and LVMI (r=-0.33, P&lt;0.05), and relative wall thickness (r=-0.43, P&lt;0.01). Conclusion: A decrease in endocardial radial strain precedes global LV dysfunction in patients with hypertension.
Perceived Coercion and Change in Perceived Need for Admission in Patients Hospitalized for Eating Disorders
Authors: Angela Guarda
Journal: American Journal of Psychiatry (2007)

Objective: Ambivalence toward treatment is characteristic of eating disorders, and patients are often admitted to inpatient programs under pressure from clinicians, family, friends, educators, or employers. This study evaluated patient perceptions of the admissions process and perceived need for hospitalization and assessed whether these perceptions remain stable in the short term. Method: A total of 139 patients with eating disorders completed a 13-item self-report scale on the admission experience when they were admitted to a behavioral inpatient specialty program and again 2 weeks into their hospitalization. Results: Patients with anorexia nervosa reported higher levels of perceived coercion and pressure and a lower sense of procedural justice than did those with bulimia. Patients under 18 (N=35) reported more perceived coercion than did adult patients (N=104), and a trend was noted for them to disagree that they needed hospitalization. Perceptions of coercion, of pressure by others toward hospitalization, and of procedural justice were stable in the short term. However, of the 46 patients (30 of them adults) who initially did not endorse needing admission, 20 patients (17 of them adults) changed their minds by 2 weeks into hospitalization and agreed that they needed hospital admission. Conclusions: Nearly half of patients with eating disorders who denied a need for treatment on admission converted to acknowledging that they needed to be admitted within 2 weeks of hospitalization. Since treatment avoidance is associated with poor outcome, these findings suggest a need for studies assessing the long-term outcome and ethics of pressuring patients with eating disorders into treatment.
PAN-AMERICAN MEDICAL CONGRESS.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
At last?
Authors: N P Sperryn
Journal: British Journal of Sports Medicine (1995)

At Last?In forty years of fighting for Sports Medicine, BASM has tried alone and tried with others.We co-founded one Institute in the sixties, which got nowhere, another in the nineties.We initiated Britain's lecture programmes, but Academe wasn't interested.That peculiarly British triad of inertia, prejudice and conservatism denied both athlete and doctor.Society changed, medicine subtly slid from disease towards fitness.We sought specialist training and recognition, with jobs in reputable institutions for the new generation.We hoped to end our outcast phase as a specialty synonymous with embrocation and adverts in changing rooms.'If 'sports medicine' is to avoid becoming the Pandora's Box of medicine, it is essential to counterbalance quackery with the responsible study and development of safe and reputable sports medicine practice.In all other branches of medicine this means academic, institutional and governmental recognition -why not in sports medicine?1'We recognized the need for external academic validation, hence mere certificates of attendance at our courses.Eventually the Society of Apothecaries initiated a public diploma in sports medicine and others followed.However, 'The problem is that all these (British sports medicine) diplomas tread a narrow path between specialist and generalist knowledge and expertise.Inevitably, they do not represent completion of training or specialist status.2'So, despite a strong core of General Practice based diplomates and course attenders, nothing happened for aspiring specialists.Training and consultancy criteria were defined for other specialities, but the orphan sports medicine lagged behind on academic acceptance.'While the Royal Colleges exist to promote the highest standards of medical practice, unfortunately they have, perhaps cynically and certainly selfishly, confined their interest in sports medicine to organizing examinations and extracting fees from self-taught enthusiasts while eschewing any responsible role in the practice, let alone the promotion, of the subject.3'This delayed introduction of the sort of universal standards for provision which were the hallmark of the pre-Thatcherite National Health Service.'Failure to develop consultant services has encouraged proliferation of substandard clinics.4'
Does advertising influence physicians?
Authors: T. Randall
Journal: JAMA (1991)

NUMEROUS STUDIES have attempted to determine the influence of pharmaceutical marketing practices on physician decision making. The studies are problematic, however, because they rely on physician self-reporting, introducing a strong potential bias. In an elegant study that overcomes this problem, Jerry Avorn, MD, associate professor of social medicine and health policy at Harvard Medical School, Boston, Mass, selected two classes of drugs for which messages about efficacy differed substantially between commercial and scientific sources (<i>Am J Med</i>. 1982;73:4-8). The first class, cerebral and peripheral vasodilators, were at the time widely promoted for the treatment of senile dementia and peripheral vascular insufficiency. Yet the clinical literature indicated their uselessness for these indications. The second class, the propoxyphene products (especially Eli Lilly's Darvon), were heavily promoted as effective relievers of moderately severe pain, yet the weight of evidence suggested that their analgesic properties were at best equivalent to aspirin. Avorn then sampled
... atque Vale
Authors: George Liddle Fite
Journal: JAMA (1974)

<h3>To the Reader.—</h3> With this issue ofThe Journalyour editor of LETTERS bows out to his excellent successor. After 115 months of 501 issues he bids you farewell. That's some 5,000 published letters, not to mention a rather larger number sent to the graveyard. It's been an interesting experience, always fascinating, often amusing, sometimes instructive. It has made friends, never to be met in the flesh, but pleasant to have known in correspondence. It has made a few enemies, thank goodness, all pushed beyond the three heads of Cerberus to the infernal regions. Probably the only individual to have read<i>all</i>those 5,000 letters, I have been punished amply, and will doubtless eventually ascend celestially! Farewell, dear reader. It's been nice to know you. How sad that you will have to endure life's future trammels without my blissful countenance smiling upon you.
Adverse Outcomes Associated With Use of Proton Pump Inhibitors and Clopidogrel—Reply
Authors: P. Michael Ho
Journal: JAMA (2009)

In Reply: We agree with Drs Chae and Kim that some PPIs may not be associated with attenuation of the benefits of clopidogrel. In our study, the majority of patients were prescribed omeprazole and, to a smaller extent, rabeprazole. Thus, the results are primarily referable to these agents.
Phase I Trial of EC90 (keyhole-limpet hemocyanin fluorescein isothiocyanate conjugate) with GPI-0100 adjuvant followed by EC 17 (folate-fluorescein isothiocyanate conjugate) in patients with metastatic renal cell carcinoma and ovarian cancer
Authors: R. J. Amato, J. Engel, J. Lu, P. Low, F. Naveed
Journal: Journal of Clinical Oncology (2004)

4754 Background: FolateImmune is a novel immunotherapy comprised of a vaccine EC90 with GP-0100 adjuvant and a folate-conjugated vaccine( EC-17) that targets folate receptor (FR) positive tumor cells to enhance tumor cell removal by cytokine stimulated immune cells. The over-expression of the FR occurs in a number of malignancies, including kidney, & ovarian. Methods: FolateImmune treatment begins with a series of subcutaneous inoculations of EC90 (0.2mg/dose), a KLH-FITC conjugate adjuvanted with GP-0100 (3.0mg/dose) to stimulate the production of antibodies to FITC. The patient then receives a subcutaneous injection of EC17, a folate FITC conjugate, that binds to cells over-expressing the FR and promotes their opsonization with the previously induced endogenous anti-FITC IgG. This process effectively marks the tumor cells for subsequent immune recognition. EC17 forms a molecular bridge between the tumor cell and the endogenous circulating anti-FITC IgG. This marking initiates an Fc-mediated immune response leading to the removal of the antibody-coated tumor cells. Eligibility included positive immunohistochemical confirmation of folate receptors on tumor tissue, ECOG score of ≤ 1, life expectancy >3 months, any prior chemotherapy or immunotherapy, normal organ/marrow function, measurable disease, and no active CNS disease. Results: 6 patients have been enrolled in dose level 0 of EC 17 (0.031mg/kg). 5 patients had RCC (4 patients clear cell, 1 patients papillary) and 1 patient had ovarian carcinoma. All patients had one or more prior treatments. No toxicities were seen at dose level 0. 6 RCC patients are preparing to begin dose level plus 1 (0.92mg/kg) 3 of the renal cell patients by RECIST criteria are stable and beginning a second cycle of therapy. No significant toxicity has been observed. Laboratory correlates are presently being analyzed. Conclusions: FolateImmune therapy is well tolerated with a suggestion of biologic activity reflected in that three patients are continuing therapy. Additional results will be updated at the meeting. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Endocyte
Five-Year Findings of the Hypertension Detection and Follow-up Program&lt;subtitle&gt;Reduction in Mortality of Persons With High Blood Pressure, Including Mild Hypertension&lt;/subtitle&gt;
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Carotid endarterectomy's value still uncertain
Authors: W. A. Check
Journal: JAMA (1982)

A six-year follow-up of patients undergoing carotid endarterectomy at the Mayo Clinic in Rochester, Minn, has revealed a reduction in stroke incidence that is "better than the natural history and better than alternative treatments." Neurologists Jack P. Whisnant, MD, and Burton Sandok, MD, caution, however, that this good outcome was obtained under "ideal circumstances," adding: "You certainly can't extrapolate these results to all situations." Furthermore, even though morbidity from stroke appeared to be reduced, Whisnant concedes that "I'm not sure that we've improved the overall mortality, although the presumption is that we've decreased deaths from stroke." Whisnant gave the report at the recent Joint International Conference on Stroke and Cerebral Circulation in New Orleans. Several other neurologists at the meeting underlined his caveats that these results could not be extrapolated to endarterectomy done at all hospitals and that the study does not prove that surgery alters the natural history of
Additional dose urged for some receiving Haemophilus influenzae vaccine in early '90s
Authors: C. Marwick
Journal: JAMA (1992)

PHYSICIANS are being advised that infants and children immunized with the<i>Haemophilus influenzae</i>type b conjugate vaccine PedvaxHIB<sup>©</sup>(Meningococcal Protein Conjugate) between December 1990—when the vaccine was licensed—and March 1992 should be given an additional dose. The first 16 lots of PedvaxHIB distributed to physicians may have lower than expected immunogenicity, the manufacturer says. Lots producing lower than expected immunogenicity are characterized by certain biochemical markers, and all of them have been identified, says Paul M. Mendelman, MD, clinical research director, Merck Sharp &amp; Dohme research laboratories, West Point, Pa. The issue now is those who have received vaccine from these lots, says Merck's Wayne Morges, PhD. It is impossible to define the future risk to any of these children, he says, so "our recommendation is that those who received vaccine from these lots should be given one additional dose in order to be assured of continuing protection." <h3>Letter</h3>
A call for higher standards for breast implants
Authors: D. A. Kessler
Journal: JAMA (1993)

THE COUNCIL on Scientific Affairs report on silicone gel breast implants, adopted by the AMA House of Delegates and published in this issue ofThe Journal,<sup>1</sup>represents a missed opportunity. The Council encourages physicians to become fully informed about the current scientific data on these implants, but this report fails to provide a comprehensive safety review or a balanced discussion of the issues. The Council faults others for the controversies associated with these devices today, but it overlooks the serious failings of physicians and never articulates their responsibility with regard to the safety of medical devices. The Council makes policy recommendations that ignore the FDA's statutory authority and public health responsibilities and minimize the uncertainties and concerns that continue to surround these devices. The Council report states that it reflects the scientific literature as of December 1992. However, since then, other important studies have been published. Recent animal studies
Reply to Giandomenico Roviello, Alberto Bottini, and Daniele Generali's Letter to the Editor re: Karim Fizazi, Kim N. Chi, Johann S. de Bono, et al. Low Incidence of Corticosteroid-associated Adverse Events on Long-term Exposure to Low-dose Prednisone Given with Abiraterone Acetate to Patients with Metastatic Castration-resistant Prostate Cancer. Eur Urol. In press. http://dx.doi.org/10.1016/j.eururo.2016.02.035. Corticosteroid-associated Adverse Events in Elderly Patients
Authors: Karim Fizazi, Peter De Porre, Anil Londhe, Tracy McGowan, Charles J. Ryan
Journal: European Urology (2016)
The California excise tax on cigarettes: the tobacco industry profits from this too
Authors: D. Parra-Medina
Journal: JAMA (1993)

<h3>In Reply.</h3> —We thank Dr Parra-Medina and her colleagues for pointing out an aspect of the collection of the cigarette tax in California that we were not aware of. The 0.85% discount rate given to cigarette wholesalers to offset the cost of affixing the tax stamps on individual packs of cigarettes is mandated by state law. We agree that the 25 cents per pack tax increase brought by Proposition 99 should not have increased the per-pack monetary value of the discount. We will look for ways to correct this inequity.
Journal of Wilderness Medicine
Authors: Jonathan D. Eldredge
Journal: JAMA (1992)

Every year Americans venture into wilderness areas in growing numbers and with greater frequency. The US Forest Service in 1991 reported 12.8 million visitor days to its areas designated as wilderness. An estimated 18.2 million snow skiers, 2.5 million scuba divers, 70 million swimmers, 10.8 million water skiers, 30 000 hang gliders, and 46 million fishing enthusiasts participate in their respective sports<sup>1</sup>each year in the United States, often in areas defined as wilderness. These sports can be hazardous. Six thousand people die annually while engaged in sports and recreation.<sup>2</sup>Fishing, a relatively benign activity, causes 66 000 injuries per year.<sup>1</sup>Thoreau wrote, "In wildness is the preservation of the world." But, for physicians, activities in the great outdoors cause a cascade of unusual medical problems. The<i>Journal of Wilderness Medicine</i>has found a previously unrecognized, unique niche in the medical literature. The varied range of topics
Right Atrial Electrocardiography
Authors: Leonard S. Dreifus
Journal: JAMA (1966)

Although a majority of disturbances of cardiac rhythm are easily identified by inspection, auscultation, or cholinergic stimulation, routine right atrial electrocardiography has raised serious doubts as to the precise interpretation of many simple and complex mechanisms. Early workers recognized the necessity to identify atrial and ventricular activity for the diagnosis of cardiac arrhythmias and in 1906 Cremer<sup>1</sup>first used semidirect esophageal leads to record atrial potentials. However, tracings taken by esophageal leads are often technically unsatisfactory and the method is often contraindicated in seriously ill patients. The use of a saline-filled catheter for the recording of intracavitary potentials was first introduced by Hellerstein et al<sup>2</sup>in 1949. Later, this method was modified by Dreifus et al<sup>3</sup>who used a polyethylene catheter filled with 5% saline which could be introduced percutaneously. The right atrial recordings are made by connecting the patient to an ordinary electrocardiograph. Ground wires are