tbuckley/cabot-search huggingface dataset:
Metabolism,* New York
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
James MacGregor
Authors: H. E. Robson
Journal: British Journal of Sports Medicine (1990)

It is with great regret that we heard of the death of Jimmy Moncur in December 1989 shortly after he moved from Glasgow to Wales to be near his family.He was born on 2 February 1919 and spent his early childhood in Dundee and obtained the Diploma of Physical Education at the Scottish School of Physical Education at Jordanhill College, Glasgow just before the war.During the war Jimmy served in a combatant unit and afterwards studied medicine at St Andrew's University, qualifying in 1951.After house jobs he worked as junior hospital medical officer at Bridge of Earn Hospital Fitness Centre and took the Diploma of Physical Medicine.He applied his experience as a teacher of physical education to his clinical work and it was an obvious step to sports medicine.In the late 1950s
Final challenges: real-world experience with sofosbuvir, velpatasvir and voxilaprevir in patients with advanced cirrhosis
Authors: Tim Papaluca, Stuart Roberts, Simone Strasser, Katherine Stuart, Kate New, Geoff Farrell, Gregory Dore, Alan WIGG, Aidan Woodward, Dr. Amanda Wade, Jacob George, Marie Sinclair, Bruce McGarity, A Leslie Fisher, Rohit Sawhney, Mark Wilson, Ivan Valiozis, Miriam Levy, Edmund Tse, Golo Ahlenstiel, Mazhar Haque, Emily Prewett, William Sievert, Siddharth Sood, James O’Beirne, James Thomas, Simon Hazeldine, Zina Valaydon, Mark Douglas, Scott Bowden, Jacinta O’Keefe, Jacinta Holmes, Alexander Thompson
Journal: Journal of Hepatology (2020)
The Essentials of Histology.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The patient with multiple alloantibodies
Authors: P. D. Issitt
Journal: JAMA (1982)

<h3>In Reply.—</h3> Dr Verheecke's interesting comments were directed toward a case that I did not discuss—that of the incompetent patient. I can, however, essentially agree with his observations on this matter. I cannot, however, agree with the last statement in his letter, that "the real issue... is to tell the truth according to the patient's state of mind at the moment...." I think that one has an initial obligation to be as deliberately truthful as possible. Also, the basis on which one makes a judgment pertaining to the patient's "state of mind" would have to be examined carefully. This, at least, would be necessary to make me comfortable with this notion. Finally, in response to Dr Verheecke's concern about physicians who must practice in parts of the world where people suffer from an inability to talk openly about cancer, I think that physicians have the difficult and often painful obligation
Highlights
Journal: JAMA Psychiatry (2014)

Weight Gain After Long-Term Antidepressant Use 889Blumenthal and colleagues use data from electronic health records to estimate weight gain associated with specific antidepressants during 12 months following an initial prescription.While the magnitude of weight gain was modest on average and similar among most antidepressants, the authors found significantly decreased rates of weight gain among individuals treated with bupropion hydrochloride, amitriptyline hydrochloride, and nortriptyline hydrochloride compared with citalopram hydrobromide. Posttraumatic Stress Disorder and Risk of Preterm Birth 897Yonkers and colleagues explore preterm birth risk in 2654 women followed up through pregnancy.They found that women who were in episode of both posttraumatic stress disorder and major depression were at a 4-fold increased risk of preterm birth, an association stronger than that found for antidepressant use in pregnancy.
The Metabolic Basis of Inherited Disease
Authors: John T. Garland
Journal: JAMA (1972)

This classic has grown again. Between the first and second editions the number of pages devoted to text actually decreased, though the material presented increased due to larger pages, smaller pictures, and the change to double columns. This time, the use of thinner paper has allowed the text to increase from 1,381 to 1,736 pages (plus index), without appreciable increase in size. Some may occasionally find it disconcerting to see through the pages, but the increase in content without increase in bulk is worth it (even without ecological considerations). Coupled with this has been further distillation of the older material, allowing incorporation of new data and insights as well as the addition of new entities. This book has much to offer anyone interested in metabolic and inherited diseases. For the neophyte there are concise expositions of the normal physiology to give needed perspective for the lucid discussions of most disorders.
REPORTS ON MEDICAL AND SURGICAL PRACTICE IN THE HOSPITALS AND ASYLUMS OF THE BRITISH EMPIRE
Journal: BMJ (1902)

MEIDICAL JOURNALJ lNM7 92 rhoea becoming generalized in infants.In the same year Zatvornitski2 described a case of rheumatism in an infant with ophthalmia neonatorum.In I898 Heiman, in the New York Medical Record, mentions the case of an infant in which he found gonococci in the affected wrist.Clement Lucas in £899 read a paper before the Royal Medical and Chirurgical Society, stating that he had collected 23 cases of gonorrhoeal rheumatism in infants with gonorrhoeal ophthalmia.He noted that the condition was quite a transient one, with no tendency to ankylosis.
Fusion of the NH2-terminal domain of the bHLH protein TCF12 to TEC in extraskeletal myxoid chondrosarcoma with translocation t(9; 15)(q22; q21)
Authors: Helene Sjögren, Barbro Wedell, Jeanne M. Meis Kindblom, Lars-Gunnar Kindblom, Göran Stenman
Journal: Nature Genetics (2001)

Session III8 7 northern blotting and (4) comparative genomic analysis with distant vertebrate species such as Fugu rubripes and Tetraodon nigroviridis.This transcript-mapping strategy has identified 32 potential transcription units, including 2 known genes, 5 new genes, 9 Unigene entries and 16 other expressed sequence tag clusters.The region also contains five pseudogenes.The map should facilitate subsequent efforts to characterize the candidate genes.This study illustrates how the integration of genome-based approaches facilitates the identification of genes in a large interval.
Strongyloidiasis and malignant lymphoma. "Opportunistic infection" by a nematode
Authors: W. A. Rogers
Journal: JAMA (1966)

INFECTIONS with organisms of low pathogenicity often complicate the treatment of malignant lymphoma. Bacteria and viruses harmless to healthy persons may be fatal to patients with lowered resistance; certain fungi have become notorious for such "opportunistic infections."<sup>1</sup>If a lowly fungus can be called "opportunistic," surely the opprobrium can be applied to a parasitic worm aggressively invading a weakened host. Infections with<i>Strongyloides stercoralis</i>, seldom serious in otherwise healthy persons, can cause the death of those debilitated from malnutrition or other illness. To our knowledge, strongyloidiasis has not been previously reported in association with malignant diseases of the lymphatic system. <h3>Report of Cases</h3><h3>Case 1.—</h3> A 63-year-old white farmer was admitted to the hospital after eight months of weakness, itching, cough, anorexia, and weight loss. The spleen, liver, and superficial lymph nodes were enlarged. The platelet count was 16,000/cu mm and the white blood cell count (WBC) was 2,450/cu
Psychotherapy
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 4570: Selective depletion of regulatory T cells suppressed neuroblastoma tumor growth in mice
Authors: Sophie von Lenthe, Christine Weißenborn, Ana Claudia Zenclussen, Stefan Fest, Leonid Metelitsa
Journal: Cancer Research (2019)

Abstract Purpose of the study Neuroblastoma (NB) is the most common solid extracranial tumor in childhood. Regulatory T cells (Treg) are known to have immune suppressive capacity and to be involved in tolerance establishment. As they support tumor growth and help some tumors to overcome recognition by the host, they are considered to be an important target. Treg are reportedly increased in blood of NB patients. However, there are no scientific proofs to date that they are involved in neuroblastoma growth. To address this important question we employed Foxp3-DTR mice to selectively deplete Treg upon orthotopic application of syngeneic neuroblastoma cells. Methods Orthotopic NB tumors were generated in mice Foxp3-DTR mice and in C57Bl/6J controls by subcapsular tumor cell injection of NB975A cells into the left kidney. Primary tumor growth was analysed for 23 days by high frequency ultrasound measurement. To deplete Treg, InjectionDepletion of Diphtheria Toxin (DT, 15 ng/g bodyweight) intraperitoneally every 4 days in Foxp3.DTR mice depleted the Treg pool. Control Foxp3.DTR animals received PBS and control C57B/l6 received DT. All mice were sacrificed 23 days after tumor inoculation. Tumor as wells as immune cells harvested from spleen and inguinal lymph nodes were analyzed by Flow Cytometry, Immunofluorescenceimmunohistochemistry and qRT-PCR. Results In control mice bearing tumors, Treg presence was confirmed at the contact zone between the kidney and the growing, inoculated tumor. Mice devoid of Treg (Foxp3-DTR+DT) showed a significantly reduced tumor growth compared to animals with normal Treg frequencies (Foxp3-DTR+PBS). Tumor growth in wild type controls was not affected by the application of DTR. Conclusion Ablation of Treg hindered the growth of NB, strongly suggesting their potential as therapeutic target for this aggressive childhood tumor. Citation Format: Sophie von Lenthe, Christine Weißenborn, Ana Claudia Zenclussen, Stefan Fest, Leonid Metelitsa. Selective depletion of regulatory T cells suppressed neuroblastoma tumor growth in mice [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4570.
Treatment of status asthmaticus with halothane
Authors: S. H. Schwartz
Journal: JAMA (1984)

We describe two patients with status asthmaticus who did not improve with conventional treatment and remained severely bronchospastic when mechanically ventilated. Each had a prompt bronchodilator response to the administration of halothane. We discuss the potential benefits and the possible risks of this mode of therapy. (<i>JAMA</i>1984;251:2688-2689)
Therapeutics
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
World Medical Association
Authors: Norman W. Hoover
Journal: JAMA (1970)

Comprehensive health care, health delivery systems, community medicine—these are the contemporary idiom of medical rhetoric. We have now become greatly concerned with problems which are not new to us, but only newly recognized. In his recent book,<i>Health and the Developing World</i>, John Bryant<sup>1</sup>has paraphrased a universal problem: Every medical success must be measured against the needs of all. Every effort, every cluster of resources, must be divided by the total number of people. The insistence on using this denominator—all the people—has profound social, political, ethical, and educational implications. The United States has been protected by its affluence from the compelling voice of society, until now. We are lately dealing with matters which have forced the attention of other nations for a generation. We cannot afford to ignore their experience. The World Medical Association was formed in 1947 as a meeting place and common forum for physicians of
Secretory Immunoglobulins
Authors: Thomas B. Tomasi
Journal: New England Journal of Medicine (1972)

A Number of reports in the older literature have suggested the existence of the local or regional immunity of a tissue that is not dependent on serum antibody.1 However, the concept of a more or less distinct secretory immune system developed relatively recently,2 primarily as a result of studies in man indicating that the immunoglobulin content of certain nonvascular fluids is quite different from that of serum. Most striking is the observation that immunoglobulin A (IgA), which represents a relatively small fraction (10 to 15 per cent) of the serum immunoglobulins, is the predominant species in most external secretions — . . .
Catheter and surgical treatment of cardiac arrhythmias
Authors: M. Scheinman
Journal: JAMA (1990)

Over the past decade, numerous impressive advances have been made using nonpharmacologic methods for control of cardiac arrhythmias. These methods include surgical or catheter ablation of abnormal foci. Current techniques involve catheter ablation of the atrioventricular junction to control supraventricular arrhythmias. In addition, surgical techniques have proved to be remarkably safe and effective for treatment of patients with accessory pathways and those with atrioventricular nodal reentrant tachycardia. Patients with drug-refractory ventricular tachycardia may benefit from surgical resection of the ventricular tachycardia focus. The use of these interventional methodologies has radically altered the approach to management of patients with drug-refractory cardiac arrhythmias. (<i>JAMA</i>. 1990;263:79-82)
Satellite Videoconference on Epidemiology and Vaccine-Preventable Diseases
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The differential effects of three forms of interferon alfa on hepatic regeneration after partial hepatectomy in the rat*1
Authors: S WONG
Journal: Hepatology (1995)

The purpose of this study was to determine whether all commercially available forms of interferon alfa (IFN α) have the same inhibitory effect on hepatic regeneration and whether this inhibitory effect can be prevented by putrescine, a hepatic growth promotor. Adult male Sprague-Dawley rats (n = 92) received either IFN α-2a, 2b, n1, or saline, 0 and 8 hours after partial hepatectomy (PHx) or 16 hours before PHx. A subgroup of 29 rats being treated with IFN α-2a or saline also received putrescine (5, 50, or 500 mg/kg) 16 hours before PHx. Hepatic regeneration was documented by determining [3h]-thymidine incorporation into hepatic DNA (DNA synthesis), hepatic putrescine levels, and, in selected cases, ornithine decarboxylase (ODC) activity at 24 hours after PHx. The results of the study showed that hepatic regeneration was unaffected when IFN α was administered 0 and 8 hours after PHx. When administered at -16 hours, only IFN α-2a significantly inhibited DNA synthesis and was associated with decreased hepatic putrescine levels. Inhibition was dose-dependent in that a 10-fold increase in IFN α-2a caused a further decrease in both DNA synthesis and hepatic putrescine levels. At the higher dose, IFN α-2b and n1 also inhibited DNA synthesis and lowered hepatic putrescine levels and ODC activity. Exogenous putrescine (5 and 50 mg/ kg) restored hepatic regenerative activity to normal but was toxic at high concentrations (500 mg/kg). These data indicate that not all commercially available forms of IFN α inhibit hepatic regeneration in the rat to the same extent.
Preliminary Analysis: HIV Serosurvey of Orthopedic Surgeons, 1991
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
VENESECTION.
Authors: H. B. FAVILL
Journal: JAMA (1902)

I will not apologize for occupying your attention with a topic to which I am able to bring neither new facts nor satisfactory conclusions. My excuse is the importance of the subject. You will agree with me, first, that there has been during the last few years a tendency to place a greater value on bleeding; second, that the indications for its use are vague and indefinite as now defined in the literature, and you may agree, third, that it is of the utmost importance that this procedure of recognized value be not again discredited by indiscriminate employment in obviously inappropriate conditions. Nowhere can one glean a more instructive lesson than in following the steps of Trousseau as he slowly drew away from the then dominant views as to venesection, sifting out with his rare judgment the real from the apparent and finally taking a stand that was quite out