tbuckley/cabot-search huggingface dataset:
Serum antibody to inner ear proteins in patients with progressive hearing loss. Correlation with disease activity and response to corticosteroid treatment
Authors: R. A. Moscicki
Journal: JAMA (1994)

<h3>Objective.</h3> —To test whether detection of serum antibody to a 68-kd inner ear protein distinguishes among different causes of sensorineural hearing loss, and identifies patients with active disease and those likely to respond to corticosteroid therapy. <h3>Design.</h3> —Serum samples were tested by Western blot using bovine inner ear extract as antigen, and results were correlated with patient information obtained by chart review. <h3>Setting.</h3> —Referral center. <h3>Subjects of Study.</h3> —Serum samples were obtained from patients with idiopathic, progressive, bilateral sensorineural hearing loss (IPBSNHL) (n=72) otosclerosis (n=11), Cogan's syndrome (n=8), patients with positive tests for antinuclear antibodies (n=10), and normal controls (n=53). <h3>Main Outcome Measure.</h3> —Detection of serum antibody to a 68-kd inner ear protein. <h3>Results.</h3> —Serum from 42 of 72 patients with IPBSNHL reacted with a 68-kd protein constituent of inner ear extract. This reactivity was not detected in serum from 11 of 11 patients with otosclerosis, or in eight of eight with Cogan's syndrome. It was found in serum from one of 10 patients with a positive test for antinuclear antibody and in one of 53 normal controls. Antibody to the 68-kd protein was detected in serum from 89% of patients with actively progressing IPBSNHL and none of the 25 patients with inactive disease (<i>P</i>&lt;.001). Patients who were antibody-positive responded to steroid treatment more frequently than did those who were antibody-negative (<i>P</i>&lt;.001). <h3>Conclusions.</h3> —These results indicate that the presence of circulating antibody to a 68-kd constituent of bovine inner ear extract serves as a marker for IPBSNHL and that its presence correlates with disease activity and responsiveness to corticosteroid treatment. (<i>JAMA</i>. 1994;272:611-616)
Researchers Follow Varied Molecular Paths Toward Better Control of Organ Rejection
Authors: Marsha F. Goldsmith
Journal: JAMA (1990)

GREATER SELECTIVITY leading to total acceptance is the goal of researchers seeking new antirejection drugs for persons who receive organ transplants. At the Clinical Congress of the American College of Surgeons, held in Atlanta, Ga, experts in immunology and transplantation discussed recent laboratory developments that may one day improve clinical results. Work was presented on three different compounds—an experimental molecule, a new monoclonal antibody, and a naturally occurring substance. While each one acts differently, all of the compounds specifically block the immune response to grafted foreign tissue and, in animal studies, all have been completely successful in suppressing the rejection of transplanted hearts. Fooling the immune system into thinking that a transplanted organ is self and not nonself "is not an immunologist's dream," says Randall E. Morris, MD, director, Laboratory for Transplantation Immunology, Stanford University School of Medicine, Palo Alto, Calif. He adds, "We're close to reality." <h3>Compound RS 61443</h3>
Referrals for neonatal medical care in the United Kingdom over one year. British Association of Perinatal Medicine Working Group.
Authors: Neil Mcintosh
Journal: BMJ (1989)

A survey of referrals for neonatal medical care was conducted by neonatal paediatricians in the United Kingdom from 1 August 1986 to 31 July 1987. It was intended to estimate the unmet need for neonatal medical care and to find out what happens after an attempt to transfer a pregnant woman or a baby has been unsuccessful. A total of 3734 attempts had been made, of which 1646 were for in utero cases and 2088 were for postnatal cases. Nationally, about 9% of attempts to transfer (331) were unsuccessful. In most regions a high proportion of attempts that were eventually successful had taken a considerable amount of time to arrange. It is concluded that despite a twofold increase since 1980 in the number of cots available for neonatal intensive care, arrangements for such provision in the UK are not adequate to meet every request for transfer. No health region in England or country in the UK was able to meet every request immediately, and some regions had great difficulties in arranging even those transfers that had been accepted. Such delays in transfer may lead to appreciable extra morbidity and considerable costs in future.
Biochemical Journal, London
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Legal Interventions During Pregnancy
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PNEUMONIC PLAGUE
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
WAR TIME DIFFICULTIES IN PRACTICAL DIETETICS
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Le diagnostic des phlébites des membres
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE ASSOCIATION BUTTON.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Incorrect Nonproprietary Drug Name and Approved Use
Authors: Timothy Naimi, James Mosher
Journal: JAMA (2015)

Penny F. Whiting, PhD; Robert F. Wolff, MD; Sohan Deshpande, MSc; Marcello Di Nisio, PhD; Steven Duffy, PgD; Adrian V. Hernandez, MD, PhD; J. Christiaan Keurentjes, MD, PhD; Shona Lang, PhD; Kate Misso, MSc; Steve Ryder, MSc; Simone Schmidlkofer, MSc; Marie Westwood, PhD; Jos Kleijnen, MD, PhD
March 20, 2002
Journal: JAMA (2002)

Diederik Van Dijk, MD; Erik W. L. Jansen, MD, PhD; Ron Hijman, PhD; Arno P. Nierich, MD, PhD; Jan C. Diephuis, MD; Karel G. M. Moons, PhD; Jaap R. Lahpor, MD, PhD; Cornelius Borst, MD, PhD; Annemieke M. A. Keizer, MSc; Hendrik M. Nathoe, MD; Diederick E. Grobbee, MD, PhD; Peter P. T. De Jaegere, MD, PhD; Cor J. Kalkman, MD, PhD; for the Octopus Study Group
Highlights
Journal: JAMA Surgery (2013)

Interval Appendectomy and Neoplasms of the Appendix 703Furman and colleagues hypothesized that there is an increased rate of neoplasms in adult patients undergoing an interval appendectomy.Through a retrospective review of 376 patients undergoing an appendectomy, they identified a 29.4% incidence of mucinous neoplasms in patients who had an interval appendectomy for complex appendicitis.The authors recommend interval appendectomy for all patients older than 40 years of age with complex appendicitis owing to the increased risk of neoplasms.
ANTISTREPTOCOCCUS SERUM.
Authors: D. H. BERGEY
Journal: JAMA (1904)

My investigations were undertaken with the view of obtaining information as to the identity of the streptococci found in cow's milk and their relation to the streptococci encountered in the human organism in health and disease. The reports of the agglutinating effects of the antistreptococcus sera on different cultures of streptococci by Aronson, Piorkowski and others, and the protective and curative properties of such sera reported by many investigators, raised the expectation of readily deciding on the identity of the streptococci in cow's milk as well as the possibility of throwing further light on the value and specificity of antistreptococcus sera. Goats and rabbits were treated with repeated, increasing doses of certain streptococci isolated from cow's milk and from human beings, at intervals of a week or ten days, extending over periods of several months. The sera of these animals were then tested as to their agglutinating
August Krogh (1874-1949) the physiologist's physiologist
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ABSCESS OF THE LUNG
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Multicenter, Open-Label, Phase 1b Study of Carfilzomib, Cyclophosphamide, and Dexamethasone in Newly Diagnosed Multiple Myeloma Patients (CHAMPION-2)
Authors: Ralph V. Boccia, Alberto Bessudo, Richy Agajanian, Paul Conkling, Wael Harb, Hui Yang, Dawn Pinchasik, Amy S. Kimball, James R. Berenson
Journal: Blood (2016)
Missed Opportunities for Prevention of Tuberculosis Among Persons With HIV Infection—Selected Locations, United States, 1996-1997
Journal: JAMA (2000)

Public health contact investigations are conducted to find persons who have been exposed to patients with active tuberculosis (TB) and to evaluate and treat those contacts for TB infection and active TB. Persons in close (i.e., prolonged, frequent, or intense) contact with patients with active TB are at high risk for TB infection. The risk for TB infection is increased greatly if the close contact is infected with human immunodeficiency virus (HIV) (1,2). Isoniazid (INH) treatment for latent TB infection (LTBI) reduces the riskfor developing active TB by 41%-92% (1). This study examined the clinic records of TB programs to determine whether these programs used recommended practices to manage HIV-positive persons exposed to TB (3-8). The study suggests TB programs need to review their contact investigation policies, procedures, and outcomes to reduce missed opportunities for preventing active TB among HIV-positive close contacts.
Generalized acquired cutis laxa associated with coeliac disease: evidence of immunoglobulin A deposits on the dermal elastic fibres
Authors: V. GARCÍA-PATOS, R.M. PUJOL, M.A. BARNADAS, M. PÉREZ, A. MORENO, J. CONDOMINES, C. GELPI, J.L. RODRÍGUEZ, J.M. MORAGAS
Journal: British Journal of Dermatology (1996)
Physicians' attitudes toward using deception to resolve difficult ethical problems
Authors: D. H. Novack
Journal: JAMA (1989)

To assess physicians' attitudes toward the use of deception in medicine, we sent a questionnaire to 407 practicing physicians. The questionnaire asked for responses to difficult ethical problems potentially resolvable by deception and asked general questions about attitudes and practices. Two hundred eleven (52%) of the physicians responded. The majority indicated a willingness to misrepresent a screening test as a diagnostic test to secure an insurance payment and to allow the wife of a patient with gonorrhea to be misled about her husband's diagnosis if that were believed necessary to ensure her treatment and preserve a marriage. One third indicated they would offer incomplete or misleading information to a patient's family if a mistake led to a patient's death. Very few physicians would deceive a mother to avoid revealing an adolescent daughter's pregnancy. When forced to make difficult ethical choices, most physicians indicated some willingness to engage in forms of deception. They appear to justify their decisions in terms of the consequences and to place a higher value on their patients' welfare and keeping patients' confidences than truth telling for its own sake. (<i>JAMA</i>. 1989;261:2980-2985)
Neuromuscular Disorders
Authors: David H. Morse
Journal: JAMA (1992)

In his inaugural editorial for<i>Neuromuscular Disorders</i>, Victor Dubowitz reviews the many active research fronts that form the core subject matter for this new publication. He emphasizes the rapidly advancing identification and manipulation of the genes responsible for inherited neuromuscular disorders, as well as the biochemical pathogenesis and clinical characterization of these diseases. Given the intense research activity and notable successes of neuromuscular research during the past two decades, it is easy to agree with the editor that the time has come to establish such an international, multidisciplinary journal. The journal was launched at the Seventh International Congress on Neuromuscular Diseases in September 1990, and the success of that congress, attracting over 2000 participants, is a measure of the vitality and cohesiveness of the international research community that will be contributing to the journal. Although the authors in the first three issues of the journal are primarily European, there are
Overview of Ultraviolet Radiation and Cancer: What Is the Link? How Are We Doing?
Authors: Martin A. Weinstock
Journal: Environmental Health Perspectives (1995)

Sun exposure has now been established as the most important avoidable cause of nonmelanoma skin cancer (NMSC) and melanoma.With specific reference to melanoma, there are several key issues that remain to be resolved.These include definition of the action spectrum, the importance of systemic effects of sun exposure, whether a tan is protective, the risk of tanning booth exposures, and the efficacy of sunscreens.Also the role, if any, of sun exposure in noncutaneous malignancies remains to be established.Melanoma incidence and mortality have increased dramatically over the past several decades, but these increases have now slowed, and for mortality among those 15 to 45 years of age, decreasing rates are now observed.Improving the coverage of the Surveillance, Epidemiology, and End Results (SEER) registries by requiring pathology laboratories in non-SEER areas to report cancers among SEER area residents will allow correct interpretation of these trends in the future at minimal cost.The available data on trends in NMSC incidence and mortality are suboptimal but suggest a pattern of declining mortality despite increasing incidence.Trends in NMSC morbidity have not been defined.Establishing NMSC registries in a few diverse sentinel areas would allow more reliable inference and monitoring.Techniques are being developed for reducing sun exposures and increasing early detection of skin cancers in the general population, but improved monitoring of incidence, mortality, and morbidity is required to monitor the effects of current and future ozone depletion and to evaluate prevention and early detection measures.-