tbuckley/cabot-search huggingface dataset:
Therapy of peptic ulcer
Authors: J. I. Isenberg
Journal: JAMA (1975)

THE PURPOSE of this article is to serve as a guide to the management of gastric or duodenal ulcer. Therapy is directed at four aspects of ulcer disease: (1) relief of ulcer pain, (2) hastening of ulcer healing, (3) prevention of complications, and (4) decrease or elimination of recurrences. The available treatment consists mainly of antacids and anticholinergic drugs. Regrettably, there are still many unanswered questions regarding the efficacy of these drugs in ulcer therapy.<sup>1,2</sup> <h3>ANTACIDS</h3> Antacids have been in use for acidpeptic disease since the first century AD. The rationale for their use includes the following: (1) Ulcer does not occur in the absence of gastric acid. This has been referred to as Schwartz's dictum: "no acid—no ulcer." (2) Peptic activity decreases as gastric acidity decreases. (3) Experimental ulcer formation is inhibited by antacids. (4) Acid-reducing operations usually cure ulcer. Recent studies with antacids have disclosed certain important
QuickStats:Prevalence* of Abnormal Cholesterol† Levels Among Young Persons Aged 6–19 Years, by Sex and Weight Status§ — National Health and Nutrition Examination Survey, United States, 2011–2014
Journal: MMWR Morbidity and Mortality Weekly Report (2016)

During 2011-2014, 21.0% of young persons aged 6-19 years had at least one of the three indicators of abnormal cholesterol. A larger percentage of persons categorized as obese (43.3%) had abnormal cholesterol than persons categorized as normal weight or overweight (13.8% and 22.3%, respectively). This pattern was found for both males and females. There were no significant differences between males and females in the prevalences of abnormal cholesterol within each of the weight status groups (e.g., males with obesity compared with females with obesity).
Posttraumatic stress disorder from pentaborane intoxication. Neuropsychiatric evaluation and short-term follow-up
Authors: J. J. Silverman
Journal: JAMA (1985)

Fourteen individuals briefly exposed to a toxic industrial compound, pentaborane, were evaluated for neuropsychiatric abnormalities four to 12 weeks after exposure. Results of physical, neurological, and routine laboratory evaluations were normal. Initial and persistent psychiatric symptoms, neuropsychological deficits, electroencephalographic changes, elevated central nervous system neurotransmitter levels, and ventricular brain ratios (computed tomographic scan) provide evidence of central nervous system damage. Seven patients met diagnostic criteria of the<i>Diagnostic and Statistical Manual of Mental Disorders</i>, ed 3, for posttraumatic stress disorder, and seven patients had neuropsychological test evidence of mild brain dysfunction. No statistically significant relationship was found between neuropsychiatric test results and psychiatric diagnoses. These results contradict previous literature that reports most symptom resolution within the first week after exposure to pentaborane. Results suggest that patients suffered a combination of organic brain insult and psychological trauma. (<i>JAMA</i>1985;254:2603-2608)
Phase I trial of ALT-801, a first-in-class T-cell receptor (TCR)-interleukin (IL)-2 fusion molecule, plus gemcitabine (G) for Bacillus Calmette Guerin (BCG)-resistant non-muscle-invasive bladder cancer (NMIBC).
Authors: Guru Sonpavde, Charles Joel Rosser, Chong-xian Pan, Rahul Atul Parikh, Jeffrey Nix, Jeffrey R. Gingrich, Liza Hernandez, Bee-Yau Huang, Hing C. Wong
Journal: Journal of Clinical Oncology (2015)

e15509 Background: Novel agents are necessary to treat BCG-resistant NMIBC to avoid radical cystectomy (RC). This phase I clinical trial evaluated the safety and activity of ALT-801, a recombinant humanized TCR-IL-2 fusion protein in BCG-resistant NMIBC Methods: This is a Phase I trial using the 3+3 design to evaluate intravenous (IV) ALT-801 plus IV G 1000 mg/m2 in BCG-resistant high-risk NMIBC patients (pts) defined as high grade Ta, T1 or carcinoma in situ, size > 4 cm or multi-focal tumors. BCG-intolerant pts,those who refused or were medically unfit to undergo RC were also eligible. Initially, patients received ALT-801 monotherapy; an amendment added G. Pts received induction of 2 cycles, with a 13-day rest between cycles. Each cycle consisted of 4 doses of ALT-801 on Day 3, Day 5, Day 8, and Day 15 and 2 doses of G, one each on Day 1 and Day 8. Pts who have a biopsy-proven complete response (CR) after induction received one maintenance cycle and then underwent confirmatory response assessment. The initial dose of ALT-801 was 0.08 mg/kg with 2 step-down doses allowed if dose limiting toxicities (DLTs)- 0.06 mg/kg and 0.04 mg/kg. Results: 2 pts in cohort one received ALT-801 alone at 0.08 mg/kg per dose, a 3rd pt received G and ALT-801 at 0.08 mg/kg per dose. Grade ≥ 3 hepatotoxicity in the 3rd patient led to a step-down to 0.06 mg/kg dose. One pt in the 0.06 mg/kg dose experienced a DLT (Grade ≥ 3 hepatotoxicity) and the cohort was expanded to 6 pts with no further DLTs. Other attributed adverse events were: anorexia, pruritus, rash, edema, fatigue, chills. 6 pts received up to 2 cycles of induction and 4 pts received the maintenance cycle. All pts have completed therapy except one has completed the first cycle of therapy without DLTs. Confirmed CR was observed in 2 pts, which was durable lasting ≥ 12 months. Preliminarily immune studies have shown transient IFN-γ and IL-6 but not TNF-α and IL-10 induction after ALT-801 dosing. Conclusions: ALT-801 plus gemcitabine was feasible in BCG-resistant NMIBC and demonstrated immune responses and potential durable clinical activity. Clinical trial information: NCT01625260.
Arab physicians and Israeli teachers. The Gaza Strip in 1974
Authors: A. Soffer
Journal: JAMA (1974)

EACH week, 70 physicians crowd into a small lecture room adjacent to the outpatient clinic of the Shifa Hospital in the city of Gaza. The practicing clinicians, residents, and interns who comprise this "class" come regularly to attend a series of lectures in electrocardiography and clinical cardiology. Unusual? Not for the average hospital in the United States, but these are Arab physicians trained in Egypt, and the lecturers are Israeli physicians who have been sent to Gaza by the University of Tel Aviv through the cooperation of the Israeli Ministry of Health. As a visiting faculty member of the Sackler School of Medicine of Tel Aviv University, I conducted this course and thus was privileged to learn the story of the evolution of this striking example of cooperation between Arabs and Israelis in the administered territories. <h3>Israeli Physicians for El Arish</h3> The 20th century has not been kind to the
Anesthesiology
Authors: Alex Macario
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Burkitt's tumor as a stalking horse for leukemia
Authors: J. H. Burchenal
Journal: JAMA (1972)

The<i>Oxford Universal Dictionary</i>defines a stalking horse as "a horse trained to allow a fowler to conceal himself behind it or under its coverings in order to get within easy range of the game without alarming it." Thus the title and its definition are meant to suggest that a careful study of Burkitt's tumor may provide a useful approach to the eventual control of acute leukemia. The original interest of our group in Burkitt's tumor<sup>1</sup>began with the assumption that 5-fluorodeoxyuridine might be of benefit in the treatment of cancer of the liver, which is so prevalent in some parts of Africa. It was at that time that Wood told us of the work Clifford was doing on nasopharyngeal carcinoma in Nairobi and suggested that Kenya might also be an excellent place to start our work on the treatment of liver cancer. From our original exploratory trip in
The Teeth and the Mouth.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Respiratory depression following use of antibiotics in pleural and pseudocyst cavities
Authors: E. W. Davidson
Journal: JAMA (1966)

IN A RECENT REVIEW, Emery documented 22 cases in which the intraperitoneal use of neomycin sulfate or streptomycin sulfate during surgery was implicated as the cause of severe respiratory depression.<sup>1</sup>On the other hand, few examples of this complication have been reported following the intrapleural use of these drugs.<sup>2-4</sup>During a six-month period at Jackson Memorial Hospital, severe respiratory depression has been observed in three patients following the use of neomycin and bacitracin solution during surgery. In two patients, the antibiotics were instilled into the pleural cavity and in the third into a pancreatic pseudocyst and sinus tract. <h3>Report of Cases</h3><h3>Case 1.—</h3> A 46-year-old, 75 lb (34 kg) white woman with pulmonary emphysema and a recurrent spontaneous pneumothorax on the right was treated with a thoracotomy tube connected to underwater drainage. Both lungs were clinically expanded and a chest x-ray film showed bilateral fibroemphysematous lung disease. Results
To Sleep: To Die
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
&lt;emph type="ital"&gt;KRAS&lt;/emph&gt; Genotypes and Outcome in Patients With Chemotherapy-Refractory Metastatic Colorectal Cancer Treated With Cetuximab
Authors: Eeonora Zaccarelli
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 811: Natural History and Expanded Clinical Profile of Stress (Tako-Tsubo) Cardiomyopathy in United States Women
Authors: Scott W Sharkey, Denise C Windenburg, Robert G Hauser, John R Lesser, Barry J Maron
Journal: Circulation (2008)

Stress cardiomyopathy (SC) is a newly reported condition of older women, triggered by emotionally and physically stressful events, characterized by acute heart failure with a distinctive angiographic profile, and regarded as a reversible process. To date, extended follow-up of SC patients is largely unavailable. We have assembled a substantial consecutive group of patients with SC to assess short and long-term clinical consequences of this condition. Between 2001–2008, we prospectively identified and followed (mean 2.0 years, range 0–6.7) 113 consecutive women with SC at a tertiary care United States hospital. Patients were female, aged 32–92 years (mean 68±13), and 16 (14%) were &lt; 55 years. In 105 (93%) a triggering stressful event (emotional in 50, acute illness in 55) was identified; however, in 8 patients (7%) no such event preceded SC. The ECG showed ST-segment elevation in 58(51%) patients and ejection fraction (EF) was 31±11%. Troponin was elevated in 109 (96%); peak troponin (T) was 0.64±0.76 ng/ml. Of the 113 patients, 110(97%) survived the acute event: 3 patients (3%) died in-hospital (cardiogenic shock in 2; subarachnoid hemorrhage in 1). Other complications included: cardiac arrest 2 (2%), hypotension requiring inotropic drug and/or intra-aortic balloon pump in 22 (19%), pulmonary or cerebral embolism in 3 (3%), left ventricular (LV) or right ventricular thrombus in 7 (6%) and LV outflow obstruction in 13 (12%). CMR findings included absent delayed hyperenhancement (gadolinium) in 82/83 (99%), normal LV apical contraction in 46%, RV akinesia in 22%, and pleural effusions due to heart failure in 46%. At follow-up, EF returned to normal in all patients, but one or more SC events recurred in 7 (6%) patients (complicated by non-fatal cardiac arrest in 1), of whom 3 were taking beta-blockers. Post-hospital death occurred in 15 (13%) patients of which 14 were noncardiac and 1 of unknown cause. Among this large cohort of women, some SC events occurred atypically either without a stress trigger or in younger premenopausal patients. SC also led to death in the acute phase or to later non-fatal recurrences of SC or cardiac arrest in about 10%. Therefore, the clinical profile of SC is much broader than previously regarded.
Anatomically Correct
Authors: Laurence J. Purdy
Journal: JAMA (1987)

Walking to the morgue, I couldn't help thinking of a friend of mine who recently lost a child at term, a tragedy for him and his wife. For weeks the effects of this loss worked on him and changed him; he buried himself deeper in his work and lost, along with the child, his remarkable sense of humor that formerly had made work for everyone in the lab that much more enjoyable. As I opened the door of the morgue, I was struck hard by the thought of the pain that another set of parents must be suffering at this very moment. Before beginning the autopsy, I played out the scenario that happens all too often in these circumstances, that the child will appear perfectly normal and no anatomic defect will be seen to explain the intrauterine death, leaving the parents with the burden of resolving their own private guilt,
T-wave changes with inspiration
Authors: C. W. Adams
Journal: JAMA (1971)

Two instances of T-wave changes without evidence of underlying organic disease occurred. In the first case, T-wave inversion uniquely responded to inspiration. This phenomenon was consistently repeated for six years. In the second case, atrial depolarization and ventricular repolarization appeared to be influenced by inspiration. Whenever nonspecific T-wave changes in the precordial leads are found, inspiration may influence T-wave polarity to suggest causes other than organic heart disease.
Archiv für Japanische Chirurgie, Kyoto
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diagnostic Methods, Chemical, Bacteriological and Microscopical.
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A new look at typhoid vaccination. Information for the practicing physician
Authors: B. A. Woodruff
Journal: JAMA (1991)

Most cases of typhoid fever in the United States occur in international travelers, with the greatest risk associated with travel to Peru, India, Pakistan, and Chile. Laboratory workers and household contacts of long-term carriers are also at greater risk than the general population. Decisions to the use typhoid vaccine involve weighing the risk of illness against the risk of vaccine reactions. Until recently, the only typhoid vaccine commercially available to US civilians was a heat-phenol—inactivated parenteral product that is 51% to 77% effective in preventing typhoid fever but frequently produces local pain and swelling, fever, headache, and malaise. A new orally administered, live-attenuated vaccine, made from the Ty21 a strain of<i>Salmonella typhi</i>, has been recently licensed in the United States. This vaccine provides equivalent protection with a much lower incidence of adverse reactions. It is administered in a four-dose series given over 7 days. Since neither vaccine offers total protection, the most important elements in prevention of typhoid fever remain sound biosafety precautions in laboratory workers and care in selecting food and beverages by those traveling to areas where typhoid fever is endemic. (<i>JAMA</i>. 1991;265:756-759)
Adoptive Immunotherapy With Autologous CD3/CD28-Costimulated T-Cells After Fludarabine-Based Chemotherapy In Patients With Chronic Lymphocytic Leukemia
Authors: Stephen J. Schuster, Chitra M. Hosing, Elizabeth J Shpall, Bruce L. Levine, Nicole A. Aqui, Elise A. Chong, Jakub Svoboda, Doyle Bosque, Julio Cotte, Zhaohui Zheng, Indreshpal Kaur, Elizabeth Veloso, Catherine M. Bollard, Michael J. Keating, Carl H. June
Journal: Blood (2013)
AMA-RPS Assembly Elects New Governing Council
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal