tbuckley/cabot-search huggingface dataset:
Viewing the Journal of the National Cancer Institute
Authors: John C. Bailar III M.D., Ph.D., Vivian J. Heston
Journal: CA A Cancer Journal for Clinicians (1975)

Cutler et al. (National Cancer Institute, Bethesda, Mary land) report on the data collected during 1969-71 in the Third National Cancer Survey, which gives information on mor bidity from cancer in the United States.A total of 181,027 new cancers were diagnosed in thesethree years, not includ ing in situ carcinomas andnonmelanoma skin cancers.Data are given on the incidence of cancer by primary site, sex and race.Detailed histology is available for each carcinoma.The survey also includes a 10 percent sample on which data were collected pertaining to duration and cost of hospitaliza tion, sources of payment, extent of disease at diagnosis and treatment.The high-resolution anion-exchange chromatography de scribed by Mrochek and co-workers (Oak Ridge National Laboratory, Oak Ridge, Tennessee) provides the necessary resolution for the separation and quantitative analysis of spe cific tRNA degradation products in human urine.The data in dicate that children excrete these degradation products at a 60 percent higher level than do adults.Adult cancer patients have an elevated urinary excretion of those products as com pared with their normal control counterparts.Preliminary re sults with Burkitt's lymphoma patients suggest that the urine levels for these nucleic acid derivatives parallel the response to drug therapy, with a return from elevated to normal levels being associated with tumor regression or remission.In a cross-sectional survey of 134 persons with histories of breast cancer and 260 controls, Craig et al. (Johns Hopkins University School of Medicine, Baltimore, Maryland) find that increased risk of breast cancer is associated with a posi tive family history of breast disease and first childbirth at age 25 or older.There is a suggestion of increased risk with breast feeding.When cases are divided into early onset (be fore age 45) and late onset (45 and older), the first two risk factors are significantly associated with early onset, but
May 33rd
Authors: Ayan Panja
Journal: BMJ (2004)

BBC1, 21 April 2004 at 9 pm Rating: ![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img>![Graphic][4]</img> Much debated and relatively rare, dissociative identity disorder is a condition in which a patient has two or more personalities. It is purported to follow severe childhood trauma or abuse and is assumed to be a protective mechanism of the mind. May 33rd , Guy Hibbert's drama about this disorder, used accounts from women who claim to have suffered ritual abuse to create the character of 35 year old Ella Wilson. In Ella we saw how the change from one personality … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif [4]: /embed/inline-graphic-4.gif
Persistence of reduction in blood pressure and mortality of participants in the Hypertension Detection and Follow-up Program. Hypertension Detection and Follow-up Program Cooperative Group
Authors: Neil Shulman, Elbert Tuttle, George Entwisle, Aristide Apostolides, Albert Oberman, Harold W. Schnaper, Edward H. Kass, James O. Taylor, B. Frank Polk, Jeremiah Stamler, Rose Stamler, Flora Gosch, Nemat O. Borhani, Beth Newman, Linda Harlan, Marshall Lee, John W. Jones, Sandra A. Daugherty, H. A. Tyroler, Curtis G. Hames, Siegfried Heyden, Lawrence M. Slotkoff, Socrates Fotiu, Herbert G. Langford, John Abernathy, Myra Tyler, Morton H. Maxwell, Andrew J. Lewin, Roger Detels, Reuben Berman, Ronald J. Prineas, Richard S. Crow, M. Donald Blaufox, Sylvia Wassertheil-Smoller, C. Hilmon Castle, Josephine Kasteller, C. Morton Hawkins, Charles E. Ford, Barry R. Davis, Agostino Molteni, Kenneth A. Schneider, Edward J. Fitzsimmons, Ronald J. Prineas, PhD, PhD, Gerald H. Payne, Thomas P. Blaszkowski, William J. Zukel, Alvin P. Shapiro, Glenn E. Bartsch, Kenneth G. Berge, Edward S. Cooper, Edward D. Frohlich, Richard H. Gadsden, David L. Sackett, Joseph A. Wilber, W. McFate Smith, Walter M. Kirkendall, Curtis L. Meinert, Louis S. Monk, Richard D. Remington, Max Halperin
Journal: JAMA (1988)

The Hypertension Detection and Follow-up Program (HDFP) previously described a significant reduction in five-year, all-cause mortality in its intensively treated stepped care (SC) group relative to its referred care (RC) control group. At the time this finding was described, a proportion of the SC cohort had been treated for periods as long as 6.7 years, but comparable RC and SC mortality data beyond five years were not available. These data, which are described herein, indicate that the 6.7-year life-table mortality rates were 95.1/1000 participants for SC vs 116.3/1000 participants for RC, a larger mortality difference than was observed at five years. This favorable finding for SC extended to all major subgroups, including white women and those aged 30 to 49 years at trial entry. Six months after the close of the treatment trial, a two-year posttrial surveillance study, which extended mortality follow-up to 8.3 years, was conducted. The posttrial use of antihypertensive medication declined in SC and increased in RC participants so that by the end of the posttrial period, there was little difference in the percentages of SC and RC participants taking medication. Control of blood pressure, indicated by mean diastolic blood pressure and by percent of participants with a pressure of 90 mm Hg or less, was slightly better for SC than for RC participants (SC group, 86.5 mm Hg and 68% controlled; RC group, 87.8 mm Hg and 62% controlled). The absolute mortality advantage found at 6.7 years persisted and increased throughout the posttrial period of follow-up despite discontinuation of the formal SC therapy program. It is postulated that regression of hypertensive end-organ changes brought about by the more effective SC treatment caused this favorable outcome. (<i>JAMA</i>1988;259:2113-2122)
Recurrent porokeratosis
Authors: BEVERLEY ADRIAANS, J.R. SALISBURY
Journal: British Journal of Dermatology (1991)

Journal Article Recurrent porokeratosis Get access BEVERLEY ADRIAANS, BEVERLEY ADRIAANS Departments of Dermatology, King's College Hospital, Denmark Hill, London SE5 9RS, U. K. Dr B. Adriaans, Memorial Hospital, Shooters Hill Road, London SE18 9RS, U. K. Search for other works by this author on: Oxford Academic Google Scholar J.R. SALISBURY J.R. SALISBURY Morbid Anatomy, King's College Hospital, Denmark Hill, London SE5 9RS, U. K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 124, Issue 4, 1 April 1991, Pages 383–386, https://doi.org/10.1111/j.1365-2133.1991.tb00604.x Published: 01 April 1991
Highlights
Journal: JAMA (2014)

Transvaginal sacrospinous ligament fixation and uterosacral ligament suspension are commonly performed surgeries to correct apical vaginal prolapse.To examine their comparative efficacy and safety and to assess whether perioperative behavioral therapy with pelvic muscle training improves surgical outcomes, Barber and colleagues randomly assigned 374 women with apical vaginal prolapse and stress urinary incontinence to 1 of the surgical interventions and randomly assigned them to receive either perioperative pelvic muscle training or usual care.The authors report that 2 years after surgery, neither surgical procedure was superior to the other for anatomic, functional, or adverse event outcomes.Pelvic muscle training did not improve urinary symptoms at 6 months or prolapse outcomes at 2 years.
Prior inhaled beta agonist use does not preclude beta blocker therapy for heart failure John S. Golden, Catherine C. Fallick, Susan J. Morikawa, Donna J. Mateski, Sharon R. Josephson, Mary C. Langford, Pamela P. Barnett. Kaiser Permanente Mid-Atlantic States, Fairfax, VA
Journal: Journal of the American College of Cardiology (2001)
THYMOPHYSIN TEMESVARY
Authors: ERWIN E. NELSON
Journal: JAMA (1931)

Since 1926 there have appeared, chiefly in the German literature, a large number of papers extolling the virtues of a mixture of the extracts of thymus and posterior pituitary lobe, for use in the first and second stages of labor. It is claimed for this mixture, which is sold as "Thymophysin," that the contractions elicited by its exhibition differ from those following pituitary alone in that they are rhythmically recurring rather than maintained, as is said to be the case after pituitary alone. Because of this difference it is claimed that the preparation can be used with safety to stimulate weak pains in the first stage and to shorten the duration of the second stage of labor. <h3>REVIEW OF LITERATURE</h3><h3>Pharmacologic Literature.</h3> —Pharmacologic studies of "Thymophysin" or of a mixture of thymus and pituitary extracts are almost wholly lacking. Although most of the many clinical reports refer to the original
C11-acetate PET for docetaxel prednisone (DP) response assessment in castrate-resistant prostate cancer (CRPC).
Authors: Nancy Sharma, Yusuf Menda, Laura Boles-Ponto, Daniel A. Vaena
Journal: Journal of Clinical Oncology (2012)

83 Background: C11-acetate (acetate) positron-emission tomogram (PET) has shown promise in detection of metastasis in prostate cancer in recent studies. Our study tested the feasibility of acetate-PET to predict early response to DP in CRPC. Methods: Men with metastatic CRPC for whom DP was indicated were enrolled in a prospective study of acetate-PET imaging and bone scans. Patients (pts) were imaged with both modalities at study entry and after 3 cycles of DP. DP was continued beyond cycle 3 until PCWG2-defined progression or toxicity. Treating physicians were blinded to acetate-PET results. No pts were on statins. The study was IRB-approved. Results: 6 pts with documented bone metastases were imaged (5 both pre and post-therapy.) Pre-therapy acetate-PET identified osseous metastases in all 6 pts. Remarkably, in one pt with previous radiation therapy, pre-therapy acetate-PET was negative for disease in the radiated area whereas bone scan showed persistent activity. The median number of DP cycles was 7 (5-16). 4 pts had ≥ 50% PSA decline. The median time to progression (TTP) was 5 months (mo). Of the 4 pts with PSA response, 2 had response on acetate-PET with TTP 5 mo and 10 mo respectively. One pt had &gt; 50% PSA response but progression after 3 cycles based on PET, and met PCWG2 criteria for progression at 3.5 mo. The 4 th pt with PSA response had stable findings on post-therapy PET and had &gt;10 mo TTP. The pt who had no PSA response had stable post-therapy PET and had 2 mo TTP. Bone scan was stable in 4 pts and showed progression in 1 pt. Conclusions: Response or progression on acetate-PET can be seen after a few chemotherapy cycles for CRPC. This study supports the exploratory inclusion of acetate-PET in future therapeutic clinical trials, with the potential to enhance the early prediction of treatment outcome. Acetate-PET might also allow more precise identification of viable target lesions than bone scan.
Chalones Revisited
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Illustrations of the Use of the Ophthalmoscope
Authors: W. Martin
Journal: BMJ (1859)

presses on the whole of the thoracic parietes equally, and drives in the most yielding; in other words, the bony ribs, raised against it by the respiratory muscles, are able to resist it, but the soft cartilaginous portions are not.It miust be remembered, too, that the diaphragm'is attached along the margins of all the on 18 August
抗肿瘤坏死因子诱导的皮肤病变的分析揭示了辅助型T细胞1强活性以及一些显著的免疫学特性
Authors: E. Stoffel, H. Maier, E. Riedl, M.-C. Brüggen, B. Reininger, M. Schaschinger, C. Bangert, E. Guenova, G. Stingl, P.M. Brunner
Journal: British Journal of Dermatology (2018)

TNF阻滞剂是一种广泛用于治疗很多炎症疾病(包括炎症性肠病和类风湿性关节炎)的强效治疗物质。这些阻滞剂一般较为安全,但可能会引发皮肤红斑和鳞屑(看起来像是银屑病或湿疹)的副作用。使用TNF阻滞剂长达10年的患者中,有高达三分之一的患者出现这些病变。这些皮肤病变发生的原因并没有得到完全的解释。维也纳和苏黎世的研究人员旨在更好地确定严重病变的特征,包括微观、细胞和分子调查。研究人员发现,尽管大部分病变在显微镜下的确看似湿疹和银屑病,但在分子级别,某些特征却不同于传统银屑病和湿疹。在TNF阻滞剂导致的所有病变中,干扰素γ的含量较高,这种分子是由特定的免疫细胞产生的强大炎症介质。这项研究的结果可能有助于更好地指导可避免此类副作用的未来治疗方法。
Effect of interferon administration on serum hepatitis C virus RNA in patients with chronic hepatitis C
Authors: K Chayama
Journal: Hepatology (1991)

Hepatitis C virus RNA as detected by reverse transcription and nested polymerase chain reaction was monitored in 16 patients with chronic hepatitis C treated with interferon. Hepatitis C virus RNA became undetectable after 4 to 8 wk of interferon administration in 13 of the 16 patients. During 6 mo of follow-up, 5 of the 13 patients who became negative for hepatitis C virus RNA after interferon administration remained negative, and all five continued to have normal ALT levels. Repeat liver biopsy in these five patients revealed histological improvement. Antibody to hepatitis C virus, which was initially positive in all treated patients, fell to undetectable levels in three of the five patients. In contrast, aminotransferase levels rose again in all eight patients who had become hepatitis C virus RNA negative but had again exhibited hepatitis C virus RNA after completion of therapy. In 16 untreated patients, hepatitis C virus RNA remained detectable. These results indicate that detection of hepatitis C virus RNA may be useful as a marker of viral replication in chronic hepatitis C; they also suggest that interferon should again be administered to patients who become hepatitis C virus RNA negative on treatment but again exhibit this marker of viral replication when treatment is stopped. (HEPATOLOGY 1991;13:1040–1043.)
The biologic possibility of HIV transmission during passionate kissing
Journal: JAMA (1989)

<h3>To the Editor.—</h3> Piazza et al<sup>1</sup>report a study that concludes that "passionate" kissing is unsafe. (Actually, they say it is "[not] protective," a curious term. No intimate activity is itself "protective" against human immunodeficiency virus [HIV] transmission, although using a condom, for example, may be. I assume the authors mean "not protected" or "unsafe.") I find this conclusion doubtful. Since the authors base their conclusion on the presence of blood in saliva, I assume they agree that the saliva itself is not of major concern in HIV transmission.<sup>2</sup>It is only the blood—and only that quantity of blood transferred between partners—that results in infection. Further, it is infected leukocytes that are of concern, not free virus.<sup>3</sup> I present some rough calculations, always erring on the side of overestimating the infection risk: Assume that all of the after-kissing increase in saliva hemoglobin concentration found by Piazza et
Book Review Manuel de Curiethérapie. Manual of Radium Therapy . By Léon Imbert, Professeur a la Faculte de Medecine de Marseille; Raymond Imbert, Chef de Clinique. Published by Masson et Cie, Editeurs, Paris, 1932. Paper. 216 Pages. Price 22 francs.
Journal: New England Journal of Medicine (1933)
EARLY USE OF IPECAC IN DYSENTERY
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cadwallader Colden (1688-1776) Lieutenant-Governor of New York Colony
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Manual of Surgery (Rose and Carless) for Students and Practitioners.
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Jeryl Lynn strain live attenuated mumps virus vaccine. Durability of immunity following administration
Authors: R. E. Weibel
Journal: JAMA (1968)

There was no substantial decline in mumps neutralizing antibody up to two years following Jeryl Lynn strain vaccine compared with the titer one month after vaccination. The pattern of antibody persistence closely approximated that observed following natural mumps. Initially seronegative children who received the vaccine 8 to 20 months previously were followed up for immunity to natural mumps challenge during a second mumps season. Fifty-three cases of mumps occurred among 78 initially susceptible controls in contrast to two cases among 53 initially susceptible vaccinees, giving a protective efficacy of 94%. The two vaccine failures were in children who did not respond serologically to the vaccine. The pattern of antibody persistence suggests that immunity following vaccination will be lasting.
The Relationship between Blood Pressure and Environmental Exposure to Lead and Cadmium in Belgium
Authors: J. Staessen, P. Bruaux, F. Claeys-Thoreau, P. DePlaen, G. Ducoffre, R. Lauwerys, H. Roels, D. Rondia, F. Sartor, A. Amery
Journal: Environmental Health Perspectives (1988)

The question whether in the general population environmental exposure to lead and cadmium influences blood pressure after controlling for confounding factors remains debated. The environmental exposure of the Belgian population to both lead and cadmium is high as compared with other countries. The Cadmibel Cooperative Study was therefore designed to elucidate whether environmental exposure to lead and cadmium has any effect on blood pressure and renal function in the population at large. Before embarking on the large Cadmibel project, a small study was conducted. Blood pressure and the 24-hr urinary excretion of cadmium (CdU) and lead (PbU) were determined in a random 4% sample of the population of a small Belgian town. CdU averaged 0.27 micrograms/24 hr in 46 youths (mean age 14 +/- 3 years, +/- SD), increased with age, and was higher in 57 adult men (age 41 +/- 14 years), as compared with 59 adult women (age 39 +/- 14 years) (1.05 vs. 0.81 micrograms/24 hr; p less than 0.01). PbU averaged 5.8 micrograms/24 hr in youths and similarly increased with age; adult men excreted more lead than women (13.3 vs. 8.3 micrograms/24 hr; p less than 0.001). Among men, manual workers excreted more cadmium (1.4 vs. 0.8 micrograms/24 hr; p less than 0.05) but a similar amount of lead (7.0 vs. 6.9 micrograms/24 hr) as compared with office workers. In simple regression analysis, CdU was positively correlated with both systolic (r = 0.30; p less than 0.05) and diastolic (r = 0.38; p less than 0.01) blood pressure in women.(ABSTRACT TRUNCATED AT 250 WORDS)