tbuckley/cabot-search huggingface dataset:
Update in Endocrinology
Authors: Janet A. Schlechte
Journal: Annals of Internal Medicine (1999)

Letters17 August 1999Update in EndocrinologyJanet A. Schlechte, MDJanet A. Schlechte, MDUniversity of Iowa; Iowa City, IA 52242 (Schlechte)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-131-4-199908170-00013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:I agree with Heath and colleagues that the statement about marketing raloxifene for women at risk for breast cancer is a factual error. Raloxifene is indicated for prevention of osteoporosis in postmenopausal women at risk for bone loss. The other comments about fracture risk represent new information; the statement in the Update is not an error.After our Update was submitted, presentations at the European Congress on Osteoporosis (September 1998) and a joint meeting of the American Society for Bone and Mineral Research and the International Bone and Mineral Society (December 1998) reported that raloxifene is effective in ...References1. Ettinger B, Black D, Cummings S, Genant H, Glüer P, Lips P, et al . Raloxifene reduces the risk of incident vertebral fractures: 24-month interim analyses [Abstract]. Osteoporosis Int. 1998;8 Suppl 3 11. Google Scholar2. Ensrud KE, Harris S, Pols HA, Black D, Recker R, Harris S, et al . The effect of 2 and 3 years of raloxifene on vertebral and non-vertebral fractures in postmenopausal women with osteoporosis [Abstract]. Bone. 1998;23 Suppl 5 S174. Google Scholar Author, Article, and Disclosure InformationAuthors: Janet A. Schlechte, MDAffiliations: University of Iowa; Iowa City, IA 52242 (Schlechte) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoUpdate in Endocrinology Janet A. Schlechte and Robert Kreisberg Update in Endocrinology Hunter Heath III , Bruce Mitlak , and Pamela Anderson Metrics 17 August 1999Volume 131, Issue 4Page: 309KeywordsBoneBone resorptionBreast cancerClinical trialsCoronary heart diseaseElectrocardiographyEndocrinologyOsteoporosis ePublished: 15 August 2000 Issue Published: 17 August 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
LEGAL PRESUMPTION AS TO THE DEAF AND DUMB.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Secondary Malignant Neoplasms in Patients With Hodgkin's Disease
Authors: Hertha Neufeld, Brian H. Weinerman, Samuel Kemel
Journal: JAMA (1978)

Retrospective analysis of 232 cases of Hodgkin's disease (HD) treated at the University of Manitoba from Jan 1, 1965, to Dec 31, 1973, and followed up to 44.3 months disclosed five cases of secondary malignant neoplasms. Two cases of acute leukemia were discovered compared with an expected value of 0.05 in our community. All neoplasms developed in the mixed cellularity group, representing only 28% of the HD cases. Combinations of radiotherapy and chemotherapy may have increased the incidence of leukemia, but its frequency does not appear high enough to abandon combined modality treatment. (<i>JAMA</i>239:2470-2471, 1978)
Symposium on Cocarcinogenesis and Biological Effects of Tumor Promoters
Journal: JNCI Journal of the National Cancer Institute (1980)

Journal Article Symposium on Cocarcinogenesis and Biological Effects of Tumor Promoters Get access JNCI: Journal of the National Cancer Institute, Volume 64, Issue 4, April 1980, Page 991, https://doi.org/10.1093/jnci/64.4.991-c Published: 01 April 1980
Highlights
Journal: JAMA (2019)

Shortening the Course of Dual Antiplatelet Therapy 2414Patients who have undergone percutaneous coronary intervention with a drug-eluting stent may not require a prolonged course of dual antiplatelet therapy (DAPT).Watanabe and colleagues for the STOPDAPT-2 Investigators randomized 3045 patients who had undergone percutaneous coronary intervention with a cobalt-chromium everolimus-eluting coronary stent and found that 1 month of DAPT followed by clopidogrel monotherapy, compared with 12 months of DAPT with aspirin and clopidogrel, resulted in a signifi cantly lower rate of a composite of cardiovascular and bleeding events.In an Editorial, Ziada and Moliterno suggest that shortening the course of DAPT may be appropriate for patients with newergeneration stents who have a reduced risk of atherosclerosis.
CDC Offers Primer on Blast Injury Care
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Circulation's Editors' Picks: Most Important Articles Published Each Week
Journal: Circulation (2011)

The following articles are being highlighted as part of Circulation's Topic Review series. This series will summarize the most important manuscripts, as selected by the editors, published in Circulation and the Circulation subspecialty journals. The studies included in this article represent the Editors' Picks for each Circulation issue published in 2009. Parts II and III, including the Editors' Picks for 2010 and 2011, will follow in forthcoming issues.
Abstract 601: Mechanistic Dichotomy Of Resveratrol-mediated Inhibition Of Vascular Smooth Muscle Cell Proliferation And Restenosis
Authors: Alok R Khandelwal, Viktoriya Ekshyyan, Valeria Hebert, Tammy Dugas
Journal: Circulation (2007)

Angioplasty is a widely used therapy for coronary artery stenosis, but its application is limited by restenosis occuring in 30 – 40% of patients within 3– 6 months of surgery. Restenosis is due to intimal hyperplasia resulting from migration to and proliferation of vascular smooth muscle cells (VSMC) within the intima. Recent epidemiological evidence suggests red wine exerts greater cardioprotection in women than men. Our hypothesis was that the anti-proliferative effects of resveratrol are mediated by estrogen receptor stimulation. We thus determined effects of resveratrol in VSMC isolated from female rats, compared to female VSMC treated with siRNA for estrogen receptor- (ER-)α. At low doses (0.5–25 μM) resveratrol inhibited VSMC proliferation through an ER-α dependent increase in inducible nitric oxide synthase (iNOS) activity and inhibited the cells in S phase, but at high doses (50–100 μM) the mechanism was NF-κB dependent, with inhibition of cells in G 0 /G 1 phase. At all doses, resveratrol inhibited IKK activity, an upstream kinase for NF-κB activation, but its effect at low doses was partially reversed by ER-α blockade. We also found a mechanistic link between ER-α receptors, cyclooxygenase-2 (COX-2), a known modulator of VSMC proliferation, and resveratrol. At low doses, resveratrol induced COX-2 expression, consistent with ER-α stimulation, while at high doses it inhibited COX-2 protein levels, likely due to an inhibition of NF-kB. To confirm these findings in an in vivo model for restenosis, B6.129 (n=8 per group) mice were fed with a high fat diet +/− 50 mg/kg resveratrol for 2 weeks. A carotid artery endothelial denudation procedure was conducted and after recovery, the mice were again fed a high fat diet +/−resveratrol for 2 weeks. Resveratrol increased arterial iNOS activity (p&lt;0.05) and total NO production (p&lt;0.05) but inhibited NF-κB activation (p&lt;0.01). Studies in progress utilizing ER-α (−/−) mice are determining the role of ER-α in resveratrol- mediated effects and whether resveratrol prevents neointimal hyperplasia in this model. In conclusion, though resveratrol clearly inhibited NF-κB activation, it appears that it’s predominate therapeutic effect at low pharmacologically relevant concentrations is via ERα modulation.
Errors in Survey Description
Authors: Pamela Lutsey, Faye Norby, Alvaro Alonso
Journal: JAMA Internal Medicine (2020)

John J. Park, MBChB, MPH; Sarah Humble, MS; Benjamin D. Sommers, MD, PhD; Graham A. Colditz, MD, DrPH; Arnold M. Epstein, MD, MA; Howard K. Koh, MD, MPH
"IMMUN-PROTEIDINS."
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BOOK REVIEWS
Authors: H. Z. STREICHER
Journal: JNCI Journal of the National Cancer Institute (1991)

Journal Article BOOK REVIEWS Get access AIDS Vaccine Research and Clinical Trials . Scott D. Putney , Dani P. Bolognesi , eds. New York : Marcel Dekker, Inc. , 1990 , 472 pp. $99.75. HOWARD Z. STREICHER HOWARD Z. STREICHER Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of HealthBldg. 37, Rm. 6A09 Bethesda, MD 20892 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 18, 18 September 1991, Page 1340, https://doi.org/10.1093/jnci/83.18.1340 Published: 18 September 1991
More money for health.
Journal: BMJ (1971)

ated with infectious mononucleosis are serologically related but they are not necessarily identical.'3The virus associated with nasopharyngeal carcinoma also cross-reacts with EB virus.The simplest hypothesis at present is that these viruses are co-carcinogens and infection with them ensures a multiplication of cells which may be self-limited (as for infectious mononucleosis) or unrestricted (as for Burkitt's lymphoma or nasopharyngeal carcinoma), the course de- pending on other events in the history of the cells.
Calcinosis cutis in children following electroencephalography
Authors: H. E. Wiley
Journal: JAMA (1979)

WE RECENTLY cared for seven children in whom calcinosis cutis developed at the sites of EEG electrode placement. The lesion apparently is produced by penetration of calcium chloride from the EEG paste into deliberately abraded skin and may be prevented by slight alterations in techniques. <h3>Report of a Case</h3> A premature boy was transferred to a neonatal intensive care unit shortly after birth because of respiratory distress, jaundice, hepatosplenomegaly, thrombocytopenia, and an elevated IgM level. His course was complicated by pneumonia, congestive heart failure secondary to cor pulmonale, and repeated apneic episodes. His EEGs at 3 and 5 months of age were normal. Shortly after the second EEG, skin lesions were noted in the distribution of the previously applied EEG leads on his scalp and earlobes (Fig 1). Each lesion was a discrete, approximately 1-cm red papule surmounted by multiple yellowish milia. A biopsy specimen of one lesion showed a
CAISSON DISEASE.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Strong inverse correlation between serum TPO level and platelet count in essential thrombocythemia
Authors: N Tomita, S Motomura, R Sakai, K Fujimaki, J Tanabe, H Fukawa, H Harano, H Kanamori, K Ogawa, H Mohri, A Maruta, F Kodama, Y Ishigatsubo, T Tahara, T Kato
Journal: American Journal of Hematology (2000)

Serum thrombopoietin (TPO) levels in 50 essential thrombocythemia (ET) patients were measured using a highly sensitive sandwich ELISA. In nine cases, TPO levels were measured at two points with different platelet counts. ET patients showed significantly higher serum TPO levels (n = 59, 2.70 +/- 2.74 fmol/mL, P < 0.0001) than those of normal individuals (n = 29, 0.83 +/- 0.36 fmol/mL). Twenty-three previously untreated ET patients also showed significantly higher serum TPO levels (1.33 +/- 0.75 fmol/mL, P = 0.0066) than normal individuals. Extremely high serum TPO levels (5.46 +/- 3.68 fmol/mL) were observed in ET patients with normal platelet counts. Furthermore, a strong inverse correlation was found between serum TPO levels and platelet counts in ET patients (R = -0.729, P < 0. 0001). This inverse correlation also held for each of nine cases with two-point TPO measurements. In the clinical course of ET, megakaryocyte mass may parallel the platelet mass before and after chemotherapy. Although it is unknown whether overproduction of TPO exists or not in ET, total platelet and megakaryocyte mass, i.e., the total number of c-Mpl, may play a role to regulate serum TPO levels.
Informed consent.
Authors: D Williams
Journal: BMJ (1993)

15 '5 0 z I0 5 0 0 5 O I5 20 25 30 35 40 45 50 55 Vitamin K (mg/I)Plasma vitamin K concentrations at age 96-120 hours in 88 infants given I mg vitamin K intramuscularly and in 88 given 2 mg orally significant difference in the mean vitamin K con- centrations between the groups (t test), and the distributions of the concentrations were similar.None of these patients developed late haemor- rhagic disease of the newborn.These results suggest that a larger dose of vitamin K is needed for oral administration than for intramuscular administration to maintain similar plasma vitamin K concentrations at 97-120 hours.Follow up studies are needed to establish whether 2 mg vitamin K given orally at birth is as effective prophylaxis as 1 mg given intra- muscularly.
Incomplete Title
Journal: JAMA Internal Medicine (2019)

Sanjeev Budhathoki, PhD; Norie Sawada, MD, PhD; Motoki Iwasaki, MD, PhD; Taiki Yamaji, MD, PhD; Atsushi Goto, MD, PhD; Ayaka Kotemori, RD, PhD; Junko Ishihara, RD, PhD; Ribeka Takachi, RD, PhD; Hadrien Charvat, MD, PhD; Tetsuya Mizoue, MD, PhD; Hiroyasu Iso, MD, PhD; Shoichiro Tsugane, MD, PhD; for the Japan Public Health Center–based Prospective Study Group
Pathophysiology and treatment of septic shock
Authors: E. C. Rackow
Journal: JAMA (1991)

The mortality from septic shock continues to range between 40% to 60% despite advances in cardiovascular support and antibiotic therapy. Impairment of host defenses predisposes to the development of both severe infection and septic shock. The activation of a myriad of cellular and plasma mediators by microbial toxins produces the systemic and metabolic manifestations of sepsis. The clinical presentation includes characteristic clinical, hemodynamic, and laboratory abnormalities. Multiple organ systems are involved during septic shock, with outcome dependent on the circulatory response and the development of sequential organ failures. Initial resuscitation is directed at restoring tissue perfusion with fluids and vasoactive drugs, guided by assessment of the patient's hemodynamic status. Identification of the site of infection and choice of appropriate antibiotics are critical to the success of therapy. Newer therapeutic modalities include immunologic interventions that attenuate mediator activity and modulate the immune response. Pharmacologic therapies are also being developed that are aimed at blocking the actions of specific mediators. (<i>JAMA</i>. 1991;266:548-554)
Neonatal autopsies give valuable information
Journal: BMJ (2002)

Some caution is needed in interpreting Cochrane reviewsCochrane reviews contain methodological and other weaknesses, in particular the over-rating by the reviewers in their conclusions of the benefits of new interventions.Olsen and colleagues (p 829) assessed the quality of a sample of 53 reviews first published in the Cochrane Library in 1998 and found major problems in 15.The evidence did not fully support the conclusion in nine reviews, the conduct or reporting was unsatisfactory in 12, and stylistic problems (such as errors in spelling or grammar) occurred in 12.The authors say that although the Cochrane Library remains a key source of evidence on the effects of health interventions, the reviews should be interpreted cautiously.
A phase 3 study comparing switching from tenofovir disoproxil fumarate (TDF) to tenofovir alafenamide (TAF) with continued TDF treatment in virologically-suppressed patients with chronic hepatitis B (CHB): final week 96 efficacy and safety results
Authors: Pietro Lampertico, Maria Buti, Alnoor Ramji, Scott Fung, Sang Hoon Ahn, Wan-Long Chuang, Seung Kew Yoon, Jia-Horng Kao, Chi-Yi Chen, Edward Tam, Mandana Khalili, Ho Bae, Xiaoli Ma, Won Young Tak, John F. Flaherty, Anuj Gaggar, Vithika Suri, Susanna Tan, Yang Liu, George Wu, Mani Subramanian, Hie-Won Hann, Kosh Agarwal, Young-Suk Lim, Henry Chan
Journal: Journal of Hepatology (2020)
Alcoholic Hepatitis
Authors: Charles S. Davidson
Journal: New England Journal of Medicine (1971)

Frank Burr Mallory, pathologist-in-chief at the Boston City Hospital (1908–1932), first described in 19111 what we now call alcoholic hepatitis. In spite of the 60 or so years that have elapsed, we, today, have little or no knowledge of its treatment or, for that matter, of its pathogenesis. Welcome, then, are reports in which suggested treatments are carefully studied. One, evaluating adrenal steroid administration, appears in this issue of the Journal, reported by Porter and his colleagues from Seattle.Another controlled study of such treatment for this disease was recently published from Chapel Hill by Helman and his associates. . . .
Samuel H. Belgorod
Journal: JAMA (1946)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Selected New Books
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal