tbuckley/cabot-search huggingface dataset:
Journal of Neurosurgery, Chicago
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Molecular basis of the specificity of binding of glycoprotein hormones to their receptors
Authors: Y. Combarnous
Journal: Endocrine Reviews (1992)

Journal Article Molecular Basis of the Specificity of Binding of Glycoprotein Hormones to Their Receptors Get access Yves Combarnous Yves Combarnous 1Institut National de la Recherche Agronomique, Centre National de la Recherche Scientique, Unit 1291 Station de Physiologie de la Reproduction des Mammiferes Domestiques 37380 Nouzilly, France *Address requests for reprints to: Yves Combarnous, Ph.D, Institut de la Recherche Agronomique, URA CNRS 1291 Station de Physiologie de la Reproduction des Mammiferes Domestiques, 37380 Nouzilly, France. Search for other works by this author on: Oxford Academic Google Scholar Endocrine Reviews, Volume 13, Issue 4, 1 November 1992, Pages 670–691, https://doi.org/10.1210/edrv-13-4-670 Published: 01 November 1992
A Life Against Death
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Specific Accumulation and Elimination Kinetics of Tris(4-Chlorophenyl)Methane, Tris(4-Chlorophenyl)Methanol, and Other Persistent Organochlorines in Humans from Japan
Authors: Tu Binh Minh, Mafumi Watanabe, Shinsuke Tanabe, Taketo Yamada, Jun-ichi Hata, Shaw Watanabe
Journal: Environmental Health Perspectives (2001)

We examined human adipose tissue, liver, and bile from humans in Japan to understand the contamination status, specific accumulation, and elimination of two newly identified environmental contaminants, tris(4-chlorophenyl)methane (TCPMe), tris(4-chlorophenyl)methanol (TCPMOH), and other persistent organochlorines such as polychlorinated biphenyls (PCBs), DDT and its metabolites (DDTs), hexachlorocyclohexane isomers (HCHs), hexachlorobenzene (HCB), and chlordane compounds (CHLs). TCPMe and TCPMOH concentrations in Japanese human adipose tissue were slightly higher than those reported previously, indicating widespread exposure to these compounds in humans. Elevated residues of PCBs and DDTs are found in adipose tissue and liver. Concentrations in bile strongly correlated with concentrations in adipose fat and liver, which may suggest an equilibration in adipose fat/bile and liver/bile and possible biliary excretion of persistent organochlorines in humans. Composition of the organochlorines accumulated further indicates a metabolic capacity in humans higher than that of marine mammals. We observed age-dependent accumulation for TCPMe, TCPMOH, and other organochlorines, but there were no significant gender differences. p,p'-DDE and TCPMe were estimated to have low biliary excretion rate. Elimination potential of persistent organochlorines may be related to their octanol-water partition coefficient. The relationship between excretion rate and octanol-water partition coefficient may be used to predict the biliary excretion potential of some other lipophilic organochlorines such as dioxins and dibenzofurans in humans. The presence of organochlorines in bile suggests that the hepatic excretory system plays a major role in the elimination of xenobiotics in humans. To our knowledge, this is the first study of accumulation and elimination of TCPMe and TCPMOH in humans.
Characterization of pancreatic ductal adenocarcinoma patients using whole-transcriptome sequencing and copy number analysis by SNPs array techniques.
Authors: Mariacristina Di Marco, Annalisa Astolfi, Elisa Grassi, Silvia Vecchiarelli, Valentina Indio, Marina Macchini, Claudio Ricci, Riccardo Casadei, Carla Serra, Giorgio Ercolani, Donatella Santini, Antonietta D'Errico, Antonio Daniele Pinna, Francesco Minni, Laura Raffaella Martella, Giuseppe Buragina, Giovanni Brandi, Guido Biasco
Journal: Journal of Clinical Oncology (2014)

e15192 Background: Our challenge it is to implemented a whole transcriptome massively parallel sequencing (RNASeq) study and copy number analysis to better understand the PDAC molecular biology. Methods: We collected 16 PDAC samples by ultrasound-guided biopsy or surgical specimen for DNA and RNA extraction. All the samples were analyzed by RNASeq, performed at 75x2 bp on a HiScanSQ Illumina platform. Single nucleotide variants (SNVs) were detected with SNVMix2 and filterend on dbSNP, 1,000 genomes, Cosmic. Non-synonimous SNVs were analyzed with SNPs&GO and PROVEAN. Thirteen samples were analyzed by high resolution copy number analysis (CNA) on Affymetrix SNP array 6.0. Results: RNAseq results in an average of 264 coding non-synonymous novel SNVs (ranging from 146 to 374) and 16 novel Indels (ranging from 6 to 24) for each sample, of which respectively a mean of 11.2% were declared as disease related and somatic events, and 34.7% were frameshift somatic insertions or deletions. We highlighted the major oncogenic hits of PDAC, confirming KRAS mutations (93.7%) and inactivation of CDKN2A (50%), SMAD4 (50%), and TP53 (56%). One case negative for KRAS showed a G13D NRAS mutation. We also detected gene fusion in 10 samples for a total of 23 different intra- or inter-chromosomal rearrangements even if no recurrent fusion transcript was found. Most rearrangements were inter-chromosomal (66%) and did not change the reading-frame (51%). Trough SNP-Array we identified macroscopic and cryptic cytogenetic alterations in 85% of patients. Gains were observed in chromosome arms 6p, 12p, 18q and 19q that harbor KRAS, GATA6, AKT2 and CCND3,while deletions were found on chromosome arms 1p, 9p, 6p, 18q, 10q, 15q, 17p, 21q, 19p, involving TP53, CDKN2A/B, SMAD4, RUNX2, ARID1A, PTEN and STK11. Conclusions: Genetic alterations in PDCA involve several pathways such as cell migration, TGFß signaling, apoptosis, cell proliferation and particularly DNA damage repair. However, not all tumors show alterations of these signaling, and key mutations appeared to differ from one cancer to another. PDAC still represents a challenge and innovative approaches are needed to eradicate the disease.
HIV testing, counseling, and prophylaxis after sexual assault
Authors: L. O. Gostin
Journal: JAMA (1994)

THE IMPACT of possible infection with the human immunodeficiency virus (HIV) in survivors of sexual assault<sup>1</sup>has received little attention in the first decade of the acquired immunodeficiency syndrome (AIDS) epidemic. This may be due in part to society's conflicting attitudes and beliefs concerning sexually transmitted diseases (STDs), AIDS, and rape. The meaning of STDs historically has been shaped by powerful social and cultural constructions. These diseases often have been viewed as the result of socially unacceptable sexuality, a morally based failure of impulse control by individuals, and fair punishment for transgressing societal norms.<sup>2,3</sup>Similar moralistic reasoning often underlies the conventional wisdom concerning rape and AIDS. Rape, a violent crime where sex is used as a weapon, has been seen as the result of inappropriate seductive behavior or a sudden change of heart on the part of the victim who initially had consented to a sexual encounter.<sup>4</sup>
Fifty hours for the poor
Authors: G. D. Lundberg
Journal: JAMA (1987)

Doctors, lawyers, and the clergy belong to the classic learned professions, which are historically distinguished from trades and businesses. Although this distinction has blurred in modern times, one of the characteristics of a true profession remains its special relationship with the poor. Edmund Pellegrino, director of the Kennedy Institute of Ethics, states that a fundamental difference between a business and a profession is that "at some point in the professional relationship, when a difficult decision is to be made, you can depend on the one who is in a true profession to efface his own self-interest." The privilege to practice law or medicine has carried with it the obligation to serve the poor without pay. Doctors and lawyers today have tended to become overly concerned with their professional incomes and practice efficiencies, but they must not forget their higher duties. Many members of our professions have always cared for the
Incorrect Academic Degree.
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Urban Health
Authors: Russ Lopez
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
State-Specific Prevalence of Arthritis-Attributable Work Limitation—United States, 2003
Journal: JAMA (2007)

One of the Healthy People 2010 objectives calls for a reduction in the proportion of adults with doctor-diagnosed arthritis who are limited in their ability to work for pay because of arthritis (objective 2-5b). Persons who are limited in their work by arthritis are considered to have arthritis-attributable work limitation (AAWL). In the United States, AAWL affects one in 20 working-age adults (aged 18-64 years) and one in three working-age adults with self-reported, doctor-diagnosed arthritis. To estimate state-specific prevalence of AAWL and the percentage employed among working-age U.S. adults with AAWL, CDC analyzed data from the 2003 Behavioral Risk Factor Surveillance System (BRFSS) survey. This report describes the results of that analysis, which indicated that the state-specific prevalence of AAWL among all working-age adults ranged from 3.4% (Hawaii) to 15.0% (Kentucky) (median among states: 6.7%) in 2003. Among those with self-reported, doctor-diagnosed arthritis, the prevalence of AAWL ranged from 25.1% (Nevada) to 51.3% (Kentucky) (median among states: 33.0%). In every state, persons with work limitations attributed to arthritis reported being employed less frequently than working-age adults in the state overall and persons with arthritis but not work limitations. Greater use of interventions is needed to help persons with arthritis become and stay employed.
Reply
Authors: K MacDonald, E.J. Raffle
Journal: British Journal of Dermatology (1986)

Journal Article Reply Get access K MacDonald, K MacDonald Department of Dermatology, Ninewells Hospital, Dundee DDi 955, Scotland Search for other works by this author on: Oxford Academic Google Scholar E.J. Raffle E.J. Raffle Department of Dermatology, Ninewells Hospital, Dundee DDi 955, Scotland Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 114, Issue 5, 1 May 1986, Pages 636–637, https://doi.org/10.1111/j.1365-2133.1986.tb04074.x Published: 01 May 1986
A Physician's Anthology of English and American Poetry.
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Taking the final step: changing the law on euthanasia and physician assisted suicide. Time for change
Journal: BMJ (2005)

make precise conclusions about the size of the effect, though the consistency of the associations we observed between both infant size and growth and later obesity across a range of settings and time periods suggest that the association is robust.As this review was part of a much larger review it was impractical to obtain original data from study authors to carry out secondary analyses. ConclusionsInfants in the highest end of the distribution for weight or body mass index and those who grow rapidly are at increased risk of obesity in childhood and adulthood.This suggests that factors during infancy or before that are related to infant growth influence the risk of later obesity.The relation of infant growth with other health outcomes should be explored to assess whether interventions to alter infant growth to prevent obesity are likely to be associated with other benefits or harms.It will also be important to assess whether factors influencing infant growth are amenable to change, to establish which strategies might alter infant growth, and to find out whether these are acceptable to parents.
ON PYAeMIA
Authors: J. S. Gamgee
Journal: BMJ (1853)

same as the average mortality of Englnd.*I have lately again visited this establishment; and the results are even more remarkable ; for during nineteen months, up to Octo- ber 1852, with an average population of 640, there have been only thirteen deaths, being 1-2 per cent.per annum, or at the rate of only 12 in the thousand.In another establish- ment for families, in Albert Street, Spitalfields, with about 300 inhabitants, the mortality during the last eighteen months has been much lower than even that in the Pancras Road institution.The rate of mortality in England and Wales at present is 2-2 per cent., or 22 in the thousand; in the metroyolis it is 2-39, or nearly 24 in the thousand; in Liverpool it is 3 43, or upwards of 34 in the thousand; while in the part of Surrey not included in the metropolis, it is 1P72, or 17 in the thousand." But properly to estimate these facts, it must be stated that the number of children, which, if considerable, always raises the mortality, in the Metropolitan Buildings consider- ably exceeds the proportion in London generally; in 1851, for example, they formed 62-3 per cent. of the total in- mates; and yet the mortality among them was only 2,5 per cent.; whilst in the metropolis, in 1841, the number of children under ten years of age was 21-7 per cent. of the
HCV in the Australian primary care setting: real-world effectiveness of 12 weeks of sofosbuvir/velpatasvir for the treatment of chronic hepatitis C
Authors: Joss O’Loan, Anne Balcomb, David Baker, Joseph Doyle, Daniel Godfrey, Michael Kozminsky, Michael Mertens, Kim Vanstraelen, Matt Young
Journal: Journal of Hepatology (2020)
Phagolysosomal pH and Dissolution of Cobalt Oxide Particles by Alveolar Macrophages
Authors: Margot Lundborg, Rolf Falk, Anne Johansson, Wolfgang Kreyling, Per Camner
Journal: Environmental Health Perspectives (1992)

We studied phagolysosomal pH in rabbit alveolar macrophages (AM) incubated with 0-15 microM chloroquine. There was a dose-related increase in pH with chloroquine concentration. Electron microscopy showed that chloroquine increased lysosomal size. In a second experiment we studied dissolution of radiolabeled cobalt oxide particles by rabbit AM, phagolysosomal pH, and lysosomal size. The cells were incubated for 2 days with 0, 2.5, and 10 microM chloroquine. Size and pH increased with chloroquine concentration. Dissolution of cobalt particles by the AM did not clearly change with pH. In a third experiment, dissolution of cobalt oxide particles in 0.1 M acetate buffer in saline with pH 4.0, 5.0, and 6.0 was studied. At the same pH, dissolution in acetate buffer was faster than in the AM, and the dissolution appeared to decrease faster with increasing pH than in the AM. A simple model for dissolution of a particle in a phagolysosome was proposed. This model predicts the types of differences in dissolution between AM and buffered saline.
Adrenal
Authors: R. T. Kloos, F. Khafagi, M. D. Gross, B. Shapiro
Journal: Clinical Nuclear Medicine (1998)

The adrenal glands are paired retroperitoneal organs which lie superomedial to each kidney, the right adrenal gland usually being more cephaloposterior compared with the left. Each gland consists of an outer cortex and an embryologically, histologically and functionally distinct medulla. The cortex is derived from the posterior coelomic mesoderm (the urogenital ridge). The adrenal cortex can be considered as two organs: (i) the subcapsular zona glomerulosa, which synthesizes mineralocorticoids (principally aldosterone), primarily under the control of the renin-angiotensin system; and (ii) the deeper zona fasciculata and reticularis that elaborate glucocorticoids (principally Cortisol), and weak androgens [dehydroepiandrosterone (DHEA), its sulphate (DHEA-S), and androstenedione] and oestrogens primarily under the control of adrenocorticotrophic hormone (ACTH) from the anterior pituitary (Figure 10.17).
Greetings from the new Editorial Team at Cardiovascular Research
Journal: Cardiovascular Research (2003)

friendly electronic system is used for manuscript Cardiology journals and ranks number one in Europe and submission as well as the subsequent reviewing process, number two worldwide.The new Editorial Board aims to thus greatly facilitating communication during the review further develop processes successfully shaped by the process, decreasing reviewing time, and reducing submisprevious editors, who were instrumental in bringing the sion costs for contributors.Since scientific excellence is journal to its acclaimed present form, to ensure that it not an issue of regional quality, the Journal strives to remains the primary address for submission of manuscripts publish manuscripts from all over the world.on cardiac basic science.In addition,
AMA's VISION
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal