tbuckley/cabot-search huggingface dataset:
Cardiovascular effects of bretylium tosylate in acute myocardial infarction
Authors: K. Chatterjee
Journal: JAMA (1973)

The cardiac and peripheral vascular effects of bretylium tosylate (adrenergic blocking and antiarrhythmic agent) administered intravenously in doses of 5 to 10 mg/kg were evaluated in seven patients with recent myocardial infarction, three with and four without left ventricular failure (LVF). In order to clarify the effects of the drug in vivo, the effect of bretylium on isolated cat papillary muscle was also studied. The hemodynamic and peripheral vascular effects in all patients were initial transient tachycardia, hypertension and late sustained bradycardia, hypotension with decreased vascular resistance, and increased calf blood flow and venous capacitance, but without any change in cardiac output or filling pressure. In cat papillary muscle, catecholamine-release mediated positive inotropism was evident. Hence, while bretylium may have some beneficial effects in patients with LVF, it should be used with caution if hypotension exists.
Ten-Year Prospective Follow-Up Study of the Naturalistic Course of Dysthymic Disorder and Double Depression
Authors: Daniel Klein
Journal: American Journal of Psychiatry (2006)

Objective: The purpose of this study was to describe the 10-year course and outcome of dysthymic disorder. Method: The authors conducted a naturalistic, prospective, longitudinal follow-up of 97 adults with early-onset dysthymic disorder and 45 adults with nonchronic major depressive disorder selected from consecutive admissions to several outpatient facilities. Follow-up data were obtained for 90% of the cohort. Assessments were conducted at baseline, 30, 60, 90, and 120 months. Measures included the Longitudinal Interval Follow-Up Evaluation and the Hamilton Depression Rating Scale. Results: The Kaplan-Meier estimated recovery rate from dysthymic disorder was 73.9%, with a median time to recovery of 52 months. Among patients who recovered, the estimated risk of relapse into another period of chronic depression was 71.4%. Chronic depressive relapses took a variety of forms and were not limited to dysthymia. Nonetheless, the distinction between chronic and nonchronic forms of depression was relatively stable over the follow-up period. Mixed-effects models indicated that patients with dysthymic disorder experienced a significantly slower rate of improvement in symptoms over time and exhibited significantly greater depression at the 10-year point, compared to patients with nonchronic major depression. Conclusions: Dysthymic disorder has a protracted course and is associated with a high risk of relapse. The nature of chronic depressive episodes varies over time within individuals, indicating that the various manifestations of chronic depression in DSM-IV do not represent distinct disorders. However, the distinction between chronic and nonchronic forms of depression is relatively stable and may provide a useful basis for subtyping in genetic and neurobiological research.
Effect of immunoglobulin on hepatitis A in day-care centers
Authors: S. C. Hadler
Journal: JAMA (1983)

Over a 21-month interval, we investigated the effectiveness of immunoglobulin (Ig) in preventing hepatitis A spread in day-care centers. Immunoglobulin was given to all center children and employees whenever hepatitis occurred in one center child or employee or parents in two families. Immunoglobulin programs were completed in 91 centers during the trial within an average of 17 days of onset of illness in the index case. Immunoglobulin intervention caused significant reduction in the average size of a day-care hepatitis outbreak, from 7.3 cases in historically untreated centers to 6.0 cases in Ig-treated centers. Cases in center children and employees virtually ceased two weeks after Ig intervention, while those in household contacts decreased significantly within six weeks. Reported cases of hepatitis types A or unspecified in the community decreased 75% and the number of new hepatitis outbreaks decreased 77% during the trial. A decrease occurred not only in day-care-associated cases, but in cases not directly associated with centers, probably due to decreased tertiary spread from day-care families into the community. Use of Ig to prevent hepatitis spread in day-care centers seems to be an excellent means of controlling this disease, both within the centers and in the general community. (<i>JAMA</i>1983;249:48-53)
On the Pathology of Uraemia and the So-called Uraemic Convulsions
Authors: F. A. Mahomed
Journal: BMJ (1877)

THAT Bright's disease is the most frequenit cause of cerebral hbemorrhage is, perhaps, one of the most universally admitted pathological facts ; but the statement is usually made with regard to the grosser hbmorrhages, which cause death from apoplexy.It is also generally admitted that small capillary hbemorrhages frequently accompany and are seen on the outskirts of the grosser lesions; but that such minute hremorrhages occur alone, and without association with the larger ones, though under tie same conditions, does not appear very generally re- cognised, and certainly the symptoms to whiclh they give rise are alto- gether overlooked.All pathologists mention such conditions as occur- ring, usually in connectionwith disease of the vessels and other conditions to be considered hereafter, but very few attempt to associate them with any symptoms.Wilks and MIoxon, speaking of them, say: "This condition of the brain denotes a diseased state of the blood or the vessels generally, and is found in purpura, in idiopatlhic anmemia, and sometimes in fever.We think it interesting in connection with paralysis which may come on in cases of fever shortly before death; we have then found this state of capillary apoplexy to exist.It is often present also'after the convulsive attacks occasionally observed in typhus."
Abstract 472: Cardiac Fibroblasts Regulate Myocardial Proliferation and Ventricular Formation through β1 Integrin Signaling
Authors: Masaki Ieda, Takatoshi Tsuchihashi, Kathryn Ivey, Deepak Srivastava
Journal: Circulation (2008)

Ventricular cardiomyocyte proliferation is essential to support increasing hemodynamic demands during late cardiogenesis. The increase in thickness of the ventricle is achieved by greater proliferation in the compact myocardium than in the trabecular myocardium. Disruption of this process leads to a disease known as ventricular non-compaction. Although epicardial-derived signals may contribute to the proliferative process, the factors and cell types responsible for development of the compact layer are unclear. In particular, the function of embryonic cardiac fibroblasts, derivatives from epicardium, and their secreted factors are largely unknown. By analyzing cell markers, we found that cardiac fibroblasts appeared in the compact myocardium at embryonic day 12.5 and increased in number coincident with growth of the compact myocardium. Using a novel co-culture system, we found that embryonic cardiac fibroblasts were much more effective in inducing cardiomyocyte proliferation than adult cardiac fibroblasts. A genome-wide screen and siRNA knockdown experiments revealed that fibronectin and collagen were embryonic cardiac fibroblast-specific signals that promoted cardiomyocyte proliferation through β1 integrin signaling in primary culture. In vivo, cardiomyocyte expression of β1 integrin was upregulated as cardiac fibroblasts appeared in the heart and secreted extracellular matrix proteins. In agreement with a critical role for β1 integrin, cardiomyocyte-specific deletion of β1 integrin in mice resulted in reduced myocardial proliferation and ventricular compaction, with downregulation of cyclinD1 and cyclinE1 and upregulation of cyclinG2 and p21, leading to prenatal death. These findings demonstrate that cardiac fibroblasts regulate cardiomyocyte proliferation and ventricular compaction through extracellular matrix/β1 integrin signaling.
We call for <scp>iCAALL</scp>: International Collaboration in Asthma, Allergy and Immunology
Authors: J. Lötvall, R. Pawankar, D. V. Wallace, C. A. Akdis, L. J. Rosenwasser, R. W. Weber, A. Wesley Burks, T. B. Casale, R. F. Lockey, N. G. Papadopoulos, S. M. Fineman, D. K. Ledford
Journal: Allergy (2012)
MISCELLANEA MEDICA
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Evaluation of patient care. An approach
Authors: J. S. Gonnella
Journal: JAMA (1970)

This study was designed to test a new approach to the evaluation of patient care. Urinary tract infection was the disease surveyed. The objectives of the study were (1) to find the medical status of the patients prior to their first visit to the general medical clinic, (2) to compare the results of the survey with those obtained by the clinic team as recorded in the medical records, (3) to measure the knowledge of the clinic team with objective examinations, and (4) to compare performance on objective examinations with that in actual treatment situations. This approach appears to be an effective way to gather information about the quality of patient care given by physicians.
The patch test
Authors: W. B. Shelley
Journal: JAMA (1967)

Patch testing consists of the application of substances to the skin for the purpose of detecting specific hypersensitivity. It serves as an admirable diagnostic tool in the clinical study of patients who have inflammatory dermatitic reactions of an allergic nature. It allows a rapid and relatively safe review of the tolerance of the skin to a large number of materials known to cause reactions in the sensitized person. Although disarmingly simple in principle, it does require skill in execution and interpretation. It is only one cog on the diagnostic wheel! Furthermore, one must recognize that patch testing involves the deliberate reproduction of disease and as such must be employed with discretion. Admittedly the disease is miniaturized down to a patch, but nonetheless it is iatrogenic. Hence, the responsible physician will generally limit patch testing to those circumstances where the history, the localization, and a thoughtful review of the patient's contactants
SportsMedUpdate
Authors: Martin P Schwellnus
Journal: British Journal of Sports Medicine (2010)

1. Rompe JD, 2. Furia J, 3. Maffulli N . Eccentric loading versus eccentric loading plus shock-wave treatment for midportion achilles tendinopathy: a randomized controlled trial. Am J Sports Med 2009;37:463–70. [OpenUrl][1][Abstract/FREE Full Text][2] ### Background Both eccentric loading training and repetitive low-energy shock wave (SW) treatment have been shown to be effective treatment modalities for patients with chronic mid-portion Achilles tendinopathy. ### Research question/s Does combined eccentric loading and repetitive low-energy shock-wave therapy improve pain and function more than eccentric training alone in patients with chronic mid-portion Achilles tendinopathy? ### Methodology Subjects Sixty-eight subjects (18–70 years) with chronic (>6 months) non-insertional Achilles tendinopathy (clinical and ultrasound diagnosis). Experimental procedure Following assessment, subjects were randomly assigned to two treatment groups for 12 weeks: (1) eccentric training alone (ECC=34, 59% female, increasing to 3 sets of 15 loads, 2/day, 7 days/week), and (2) an eccentric training and low-intensity shock wave treatment group (ECC+SW=34, eccentric training and three-weekly sessions of shock wave treatment, 2000 pulses at three bar, the VISA score, Likert scale (1–6), load-induced pain (0–10) and side effects were recorded at baseline and at 4 months follow-up. Measures of outcome Pain and function (VISA), general assessment (Likert), load-induced pain. ### Main finding/s Likert scale 56% of the subjects in the ECC group and 82% of the patients in the ECC+SW group reported a Likert scale of one or two points ('completely recovered' or 'much improved') (p<0.05). ### Conclusion/s In a randomised controlled trial, a combination of eccentric training and low-energy shock wave therapy reduced pain and improved … [1]: {openurl}?query=rft.jtitle%253DAm%2BJ%2BSports%2BMed%26rft_id%253Dinfo%253Adoi%252F10.1177%252F0363546508326983%26rft_id%253Dinfo%253Apmid%252F19088057%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/ijlink?linkType=ABST&journalCode=amjsports&resid=37/3/463&atom=%2Fbjsports%2F44%2F4%2F294.atom
Serial coronary angiographic evidence that antioxidant vitamin intake reduces progression of coronary artery atherosclerosis
Authors: H. N. Hodis
Journal: JAMA (1995)

<h3>Objective.</h3> —To explore the association of supplementary and dietary vitamin E and C intake with the progression of coronary artery disease. <h3>Design.</h3> —A subgroup analysis of the on-trial antioxidant vitamin intake database acquired in the Cholesterol Lowering Atherosclerosis Study, a randomized, placebo-controlled, serial angiographic clinical trial evaluating the risk and benefit of colestipol-niacin on coronary artery disease progression. <h3>Setting.</h3> —Community- and university-based cardiac catheterization laboratories. <h3>Subjects.</h3> —A total of 156 men aged 40 to 59 years with previous coronary artery bypass graft surgery. <h3>Intervention.</h3> —Supplementary and dietary vitamin E and C intake (nonrandomized) in association with cholesterol-lowering diet and either colestipol-niacin or placebo (randomized). <h3>Outcome.</h3> —Change per subject in the percentage of vessel diameter obstructed because of stenosis (%S) determined by quantitative coronary angiography after 2 years of randomized therapy on all lesions, mild/moderate lesions (&lt;50%S), and severe lesions (≥50%S). <h3>Results.</h3> —Overall, subjects with supplementary vitamin E intake of 100 IU per day or greater demonstrated less coronary artery lesion progression than did subjects with supplementary vitamin E intake less than 100 IU per day for all lesions (<i>P</i>=.04) and for mild/moderate lesions (<i>P</i>=.01). Within the drug group, benefit of supplementary vitamin E intake was found for all lesions (<i>P</i>=.02) and mild/moderate lesions (<i>P</i>=.01). Within the placebo group, benefit of supplementary vitamin E intake was not found. No benefit was found for use of supplementary vitamin C exclusively or in conjunction with supplementary vitamin E, use of multivitamins, or increased dietary intake of vitamin E or vitamin C. <h3>Conclusions.</h3> —These results indicate an association between supplementary vitamin E intake and angiographically demonstrated reduction in coronary artery lesion progression. Verification from carefully designed, randomized, serial arterial imaging end point trials is needed. (<i>JAMA</i>. 1995;273:1849-1854)
Correction: Clonal Waves of Neisseria Colonisation and Disease in the African Meningitis Belt: Eight-Year Longitudinal Study in Northern Ghana
Authors: Julia Leimkugel, Abraham Hodgson, Abudulai Adams Forgor, Valentin Pflüger, Jean-Pierre Dangy, Tom Smith, Mark Achtman, Sébastien Gagneux, Gerd Pluschke
Journal: PLoS Medicine (2007)

In addition, the amino acid residues cited in the following sentence should be "1691
UNJUSTIFIABLE DISTRUST IN DIPHTHERIA ANTITOXIN.A VISITOR'S OBSERVATIONS.
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Usefulness of Oral Mucosal Transudate for HIV Antibody Testing
Authors: Kathryn Ryder
Journal: JAMA (1997)

<h3>To the Editor.</h3> —The article by Ms Gallo and colleagues<sup>1</sup>on an oral mucosal transudate (OMT) system for human immunodeficiency virus type 1 (HIV-1) antibody testing cites sensitivity as an important characteristic of this type of test. The authors demonstrate that in the general population this test will perform well, with a negative predictive value of 99.9%. Little disease will escape undetected. However, the general population has a much lower prevalence of HIV than their study population, in which 673 of 3570 subjects were positive for disease. The positive predictive value of the enzyme immunoassay (EIA) component of this test decreases from 97.5% in their sample to only 40% when applied to the general population. The OMT Western blot performs better, since none of the 2897 HIV-negative subjects in the study had a positive Western blot test result. Some still had an indeterminate test result, though, so the positive
Neurologists join neurosurgeons in urging restraint in Parkinson's surgery
Authors: B. Merz
Journal: JAMA (1989)

A SENSE OF DÉJÀ VU permeated recent sessions on brain grafts for Parkinson's disease at the American Federation for Clinical Research in Washington, DC, and the American Academy of Neurology in Chicago, as presenters offered new data while urging their colleagues to go slowly and carefully in undertaking the operation. The admonitions echoed recent warnings issued at the annual meeting of the American Association of Neurological Surgeons in Washington, DC, 2 weeks earlier, by teams who had transplanted adrenal medullary tissue into the caudate nucleus in several patients. The consensus is that while the procedure is still promising, particularly when fetal brain tissue is grafted, new side effects are continuing to emerge. At the Washington meeting, Curt Freed, MD, professor of medicine and pharmacology, University of Colorado Health Sciences Center, Denver, offered a note of promise. Freed reported that the first patient in the United States to receive a graft
Galactosemia Test as Liver Function Test
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 2646: CD39+PD-1+CD8+ T cells mediate metastatic dormancy in breast cancer
Authors: Paulino Tallón de Lara, Héctor Castañón Cuadrado, Marijne Vermeer, Nicolás Núñez, Joaquín Urdínez, Virginia Cecconi, Farkhondeh Movahedian Attar, Isabelle Glarner, Stefanie Hiltbrunner, Sonia Tugues, Burkhard Becher, Maries van den Broek
Journal: Cancer Research (2020)

Abstract Although metastatic disease can be present already at diagnosis, in some patients it appears months or years after resection of the primary tumor. This is thought to be due to the ability of some tumor cells to remain dormant after metastatic seeding. It is not known how dormancy is controlled, but there is evidence for tumor cell-intrinsic and -extrinsic mechanisms including immune defense. Here we found in preclinical models of breast cancer that metastatic dormancy was fully controlled by T cells. Through high-parametric single-cell mapping, we identified a discrete population of CD39+PD-1+CD8+ T cells present both in primary tumors and in spontaneous dormant metastasis, whereas this population is hardly found in aggressively metastasizing tumors. Surprisingly, despite expressing many exhaustion markers, this population was rich in effector molecules and cytokines that induced dormancy in tumor cells. Of note, the adoptive transfer of purified CD39+PD-1+CD8+ T cells prevented metastatic outgrowth. Thus, we discovered that primary breast tumors prime CD39+PD-1+CD8+ T cells that induce metastatic dormancy in distal disseminated tumor cells in the lungs. Citation Format: Paulino Tallón de Lara, Héctor Castañón Cuadrado, Marijne Vermeer, Nicolás Núñez, Joaquín Urdínez, Virginia Cecconi, Farkhondeh Movahedian Attar, Isabelle Glarner, Stefanie Hiltbrunner, Sonia Tugues, Burkhard Becher, Maries van den Broek. CD39+PD-1+CD8+ T cells mediate metastatic dormancy in breast cancer [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 2646.
Notice of withdrawal
Journal: British Journal of Dermatology (2020)

L. Frommherz, J. Küsel, A. Zimmer, J. Fischer, C. Has. Skin fragility caused by biallelic KRT10 mutations: an intriguing form of self‐improving epidermolytic ichthyosis https://onlinelibrary.wiley.com/doi/10.1111/bjd.18325