tbuckley/cabot-search huggingface dataset:
Abstract 421: Injection Of Self-assembled Nanopeptides With Clonal Cardiac Sca-1 Positive Cells Improve Cardiac Function After Myocardial Infarction
Authors: Masakuni Tokunaga, Toshio Nagai, Koji Iwanaga, Katsuhisa Matsuura, Toshinao Takahashi, Tomohiro Noguchi, Ping Wang, Mei Lan Liu, Tomomi Oyama, Masato Kanda, Issei Komuro
Journal: Circulation (2007)

Biological scaffolds have been reported to offer microenvironment for the transplanted cells, support the cell survival and maintain the release of paracrine factors. However, it is still unknown what kinds of cell sources, scaffolds and their delivery methods are suitable for myocardial repair. Self-assembled nanopeptides, Puramatrix (PM), have been reported to be superior to the other scaffolds in terms of its animal free origin, biodegradability and non-immunogenic properties, which are prerequisite for the clinical application. To examine whether cell transplantation with PM can restore the cardiac function of C57BL/6 mouse myocardial infarction (MI) models, we injected the cell-PM complex into the peri-MI area and then overlay a thick hydrogel patch on the MI area. The mice were divided into following groups according to the transplanted cell types and matrices; bone marrow mononuclear cells with PM (BM/PM), clonal Sca-1 positive cardiac progenitors with PM (cSca-1/PM) and PM alone (PM). Non-treated MI models (Cont) were prepared as controls. Infarct area was examined by Masson trichrome staining and cardiac dimension and function were examined by echocardiography two weeks after transplantation. cSca-1/PM and PM attenuated ventricular enlargement in comparison with BM/PM and Cont (left ventricular diastolic dimension: cSca-1/PM 4.9 ± 0.6 mm, PM 5.3 ± 1.0 mm, BM/PM 6.6 ± 0.1 mm, Cont 6.1 ± 0.1 mm). Fractional shortening of cSca-1/PM and PM were higher than that of BM/PM and Cont (cSca-1/PM 14 ± 3.2%, PM 13 ± 2.3%, BM/PM 8.0 ± 2.5%, Cont 9.9 ± 3%). Infarct area of cSca-1/PM was smaller than that of BM/PM, PM and Cont (cSca-1/PM 36 ± 12%, BM/PM 50 ± 3.1%, PM 53 ± 18%, Cont 57 ± 4.0%). To elucidate the mechanisms of the beneficial effects of cSca-1/PM complex on the infarct area, the number of CD31 positive capillary was examined by immunohistochemical method. Capillary density in the infarct area of cSca-1/PM was higher than that of PM (cSca-1/PM 15%, PM 8%). In summary, transplantation of cSca-1 in combination with PM prevents cardiac remodeling, improves cardiac contraction and reduces infarct area partially through angiogenesis. Cell therapy with PM may enable us to circumvent the current problem in the efficiency of tissue engineering-based cell therapy.
Glomerular Filtration
Authors: Eugene M. Renkin, Roscoe R. Robinson
Journal: New England Journal of Medicine (1974)

THE structural and functional unit of the kidney is the nephron. There are approximately one million nephrons in a single human kidney, each consisting of a single glomerulus of capillaries and an attached renal tubule. The elaborate tangle of interconnecting capillaries that forms a glomerular tuft has been shown beautifully in an earlier article in this series.1 The entire capillary tuft is enclosed by an epithelial capsule (Bowman's capsule), which is continuous with an epithelial sheath that invests the glomerular capillaries on the one hand and the lining epithelium of the proximal convoluted tubule on the other (Fig. 1). As . . .
THE TEACHING OF CHEMICAL PATHOLOGY.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
LICENSE REVOKED FOR IMPROPER LIQUOR PRESCRIBING.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SPINE BRACE.
Authors: A. E. HOADLEY
Journal: JAMA (1895)

The brace that I wish to describe and exhibit, is one that I have designed and adopted for mechanical support of the middle region of the spine; the range of its greatest utility being the support of the spinal column between the middle of the lumbar and the middle of the dorsal regions, although its usefulness is not strictly confined to these limits. Inasmuch as the greater number of diseases of the spinal column requiring mechanical fixation occur within this region, its usefulness will be comparatively great if found to be an efficient brace. In its simplest form the brace consists of a steel frame, a rigid chest pad and two aprons. The chest pad is adjusted in contour to fit the upper anterior portion of the chest. The pad should be in length about three times its width and adjusted transversely, resting immediately below the sterno-clavicular articulations. Its real
Out-of-hospital CPR
Authors: B. T. Jolly
Journal: JAMA (1994)

<h3>In Reply.</h3> —Our study defines the clinically useful reference ranges for serum PSA concentration according to age, using standard, well-accepted methods.<sup>1,2</sup>The so-called normal level for a given diagnostic marker should be established in a cohort of individuals with no clinical evidence of having the condition that the diagnostic marker is useful for detecting but who are at risk for developing it. For PSA the appropriate cohort is randomly chosen men between 40 and 79 years of age who have no evidence of prostate cancer by currently available diagnostic tests. When there is no clinically relevant lower limit for the diagnostic marker, the 95th percentile is used to determine the upper limit of the reference range. For PSA, these upper limits were found to be age-dependent and are as follows: 40 to 49 years of age, 2.5 ng/mL, and 70 to 79 years of age, 6.5 ng/mL. This increase
Highlights
Journal: JAMA Psychiatry (2018)

The social motivation hypothesis posits that individuals with autism find social stimuli less rewarding, but functional magnetic resonance imaging studies of reward processing have yielded mixed results.In this meta-analysis, Clements and colleagues evaluated 13 studies and found that autism was associated with aberrant decreased striatal activation to both social and nonsocial rewards.These findings suggest that in autism, there is a general rewardprocessing abnormality and not one specific to social rewards.In an Editorial, Dichter discusses implications for the field.
Biliary atresia and neonatal cholestasis
Authors: Nicholas Fidelman, Neil Mehta, Jennifer Dodge, John Roberts, Francis Yao
Journal: Hepatology (2013)

unknown.We aimed to evaluate the intention-to-treat outcome of this strategy of "wait and not ablate" for non-resection candidates with T1 HCC 1.0 to 1.9 cm.Methods: We identified 138 patients with a new diagnosis of T1 HCC by abdominal CT or MRI between 2004 and 2012.Among them, 24 patients underwent definitive LRT.The other 114 undertook the "wait and not ablate" approach of close observation with serial CT or MRI every 3 months until meeting T2 criteria and formed the study cohort.Two of the investigators performed independent review of the imaging studies to confirm the diagnosis of HCC.Competing risks (CR) regression was used to determine predictors of exclusion from LT. Results: The median age was 60 and 75% were male.There were 47.4% Caucasian, 31.6%Asian, 14.0% Hispanic, 4.4% Black, and 2.6% other race.The most common etiologies were hepatitis C (57.0%), hepatitis B (22.8%), fatty liver (10.5%) and alcohol (8.8%).The median initial tumor diameter was 1.4 cm; 91% were hypervascular and 74% displayed washout.The median time to progression beyond T1 was 6.9 months (IQR 4.6-12.0).Probabilities of progression from T1 to directly beyond T2 without LT listing were 4.4% at 6 months and 9.0% at both 12 and 24 months.Median increase in total tumor diameter was 0.14 cm per month (IQR 0.08-0.29).The 1-and 3-year survival was 94.5% and 75.5%.In multivariate analysis, predictors of rapid tumor progression, defined as a >1 cm increase in total tumor diameter over 3 months, included alcoholic liver disease (HR 6.32, 95% CI 1.3-30.84;p=0.02) and Hispanic race (HR 3.81, 95% CI 1.01-14.4;p=0.049), whereas hepatitis B appeared to be protective (HR 0.08, 95% CI 0.01-0.85;p=0.04).Predictors of exclusion from LT (with or without listing for LT under T2) by CR were AFP > 500 ng/mL (HR 12.7, 95% CI 2.8-57.0;p=0.001) and rapid tumor progression (HR 5.7, 95% CI 2.2-14.6;p<0.001).Conclusions: The "wait and not ablate" approach for T1 HCC until tumor grows to T2 stage is associated with a <10% risk of exclusion from LT due to progression to directly beyond T2 at 2 years.Those with initial AFP > 500 ng/mL and rapid tumor progression are at high risk for wait-list dropout and should receive early intervention with LRT.
RHEUMATIC FEVER
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
RADIUM THERAPY OF TERATOID TUMORS OF THE TESTICLE
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SACCHARIN
Authors: Walter A. Bastedo
Journal: JAMA (1942)

<h3>To the Editor:—</h3> InThe Journalof July 25, page 1028, there is a mild comment on the harmlessness of saccharin. Many physicians are not fully aware of its nontoxic nature and are fearful about permitting its indiscriminate use. In 1916, as a member of the Advisory Council of the New York City Board of Health, I was chairman of a saccharin committee composed of noted chemists such as H. C. Sherman and W. J. Gies. We made an extensive study of the domestic and foreign literature then available, which was considerable, and came to the conclusion that saccharin is nontoxic, either acute or chronic, for human beings, in any amounts that could ordinarily be consumed. We found an extensive use of saccharin in canned goods, chewing gum, soda water flavors, ginger ale, and so on. For Health Department purposes we concluded that "Saccharin is nonpoisonous. When used in place
Rickets: The Relative Importance of Environment and Diet as Factors of Causation: An Investigation in London.
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effects of Pre- and Postnatal Exposure to Chlorinated Dioxins and Furans on Human Neonatal Thyroid Hormone Concentrations
Authors: Hendrik J. Pluim, Jan J. M. de Vijlder, Kees Olie, Joke H. Kok, Thomas Vulsma, David A. van Tijn, Johannes W. van der Slikke, Janna G. Koppe
Journal: Environmental Health Perspectives (1993)

Animal studies have shown that dioxins influence plasma thyroid hormone concentrations. To investigate the effect of chlorinated dioxins and furans on thyroid hormone concentrations in humans, we studied 38 healthy breast-fed infants. The study population was divided into two groups according to the dioxin concentrations in milk fat of their mothers. Blood samples were taken at birth and at the ages of 1 and 11 weeks. At birth a tendency to higher total thyroxine (tT4) concentrations was found in the high exposure group. At the ages of 1 and 11 weeks the increase of mean tT4 concentrations and tT4/thyroxine-binding globulin ratios in the high exposure group reached significance as compared to the low exposure group. At birth and 1 week after birth, mean thyrotropin (TSH) concentrations were similar in both groups, but at the age of 11 weeks the mean TSH concentrations were significantly higher in the high exposure group. We postulate that the observed plasma tT4 elevation in infants exposed to dioxins before and after birth is the result of an effect on the thyroid hormone regulatory system.
Two Cases of Hysteria
Authors: J. S. Bristowe
Journal: BMJ (1879)

THE BRITISH MEDICAL _OURNAL.can be eliminated is a thing which may be demonstrated without much difficulty.a. Unexpected Pressure mzay cautse the Paroxysmz.-Aninstance of this occurred during my visit to the hospital, when neither patient, nor physician, nor bystanders had reason to anticipate the event.* Having concluded his lecture (November 17th), in which, by the way, he dis- cussed subjects other than paroxysms, and only referred to them inci- dentally, Professor Charcot withdrew from the hall.The four or five
THE NEW VOLUME.
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 174: Functional characterization of <i>ZNF750</i> in esophageal squamous cell carcinoma
Authors: Sheyne SA Choi, Valen Zhuoyou Yu, Josephine Mun-Yee Ko, Wei Dai, Maria L. Lung
Journal: Cancer Research (2019)

Abstract Background: Esophageal squamous cell carcinoma (ESCC) is a lethal and aggressive malignancy that is a threat worldwide. It is of significant prevalence in regions of Asia including Iran, Korea, Japan and especially China. Epidemiological studies of ESCC reveal genetic variations as a risk-factor to ESCC incidence. Genomic profiling of ESCC primary tumors have already identified candidate genes involved in different cellular processes such as cell cycle and apoptosis. Data from our whole exome sequencing study of primary tumors and lymph node metastases also reveal mutations involved in these pathways; however, we also uncovered an interesting candidate involved in differentiation namely, ZNF750. ZNF750 has been reported to play important roles in other squamous cell carcinomas, and as a candidate tumor suppressor gene in ESCC. Methods and Results: We exogenously upregulated ZNF750 expression by lentiviral system and used this model to investigate ZNF750 function in ESCC. By MTT 2D cell proliferation assay, we showed that in vitro cell proliferation in the ZNF750 group was hindered compared to controls. In addition, we set up 2D and 3D colony formation assays and found that the ZNF750 groups produced fewer colonies in 2D culture plates and produced significantly smaller colonies, when embedded in Matrigel. All of these findings are consistent with previous studies. We also studied the potential functional role of ZNF750 in 3D invasion/migration. Transwell permeable inserts were used to support a thick Matrigel culture with a nutrient gradient. Cells were embedded in Matrigel and moved along the gradient within the gel. After prolonged incubation (&amp;gt;2 weeks), location and size of the colonies were examined by confocal microscopy scanning. Cells with upregulated ZNF750 were found to exhibit greater mobility compared to the control cells. We also subjected ZNF750 and control groups to cisplatin to test for chemoresistance in ESCC. We found that ZNF750 expression increases chemoresistance, as opposed to the control cells. Conclusion: From these results, ZNF750 expression inhibits cell proliferation, while enhancing cell mobility and drug resistance, all of which are characteristics of cells undergoing epithelial-mesenchymal transition (EMT). We, therefore, hypothesize that ZNF750 functions in ESSC beyond that of a tumor suppressor, but as a putative EMT regulator. Acknowledgements: Research Grants Council Collaborative Research Fund grant number 106150246 and Asian Cancer Research Fund to MLL. Citation Format: Sheyne SA Choi, Valen Zhuoyou Yu, Josephine Mun-Yee Ko, Wei Dai, Maria L. Lung. Functional characterization of ZNF750 in esophageal squamous cell carcinoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 174.
In vitro tumor necrosis factor cytotoxicity in HEP G2 liver cells*1
Authors: D HILL
Journal: Hepatology (1995)

Tumor necrosis factor-α(TNF-α) is a mediator of liver injury. The objective of this study was to develop an in vitro model of TNF-mediated liver cell injury using the Hep G2 cell line. Hep G2 cells normally are insensitive to TNF cytotoxicity, but they were rendered susceptible, or sensitized, to TNF cytotoxicity by inhibitors of RNA and protein synthesis. The concentration of TNF required to kill 50% of Hep G2 cells sensitized with 0.8 pmol/L actinomycin D (Act D) was 35 pmol/L compared with 5 pmol/L for LM fibroblasts, a classic target cell used in TNF cytotoxicity bioassays. Similarly, TNF cytotoxicity occurred in Hep G2 cells sensitized with cycloheximide (CHX), and cytotoxicity to both inhibitors was dose dependent. Both protein and RNA synthesis were inhibited in Hep G2 cells by the concentrations of CHX and Act D associated with TNF cytotoxicity. Hep G2 cells pretreated with TNF alone and later exposed to normally toxic concentrations of TNF with DACT did not develop cytotoxicity. Thus,in vitro tolerance to TNF was induced. Cytotoxicity also was more severe at modestly increased temperatures (39°C versus 37°C), which may have clinical relevance to hepatic decompensation during febrile episodes. We suggest that the Hep G2 cell line sensitized by inhibiting RNA and protein synthesis is a useful in vitro model for evaluating mechanism(s) of TNF-mediated liver cell injury.