tbuckley/cabot-search huggingface dataset:
Platelet volume/count relationship aids thrombocytopenia prognosis
Authors: C. Marwick
Journal: JAMA (1983)

Capitalizing on the relationship between platelet volume and platelet number, a Texas researcher has developed a method of distinguishing those patients with certain forms of thrombocytopenia who will recover from those who will not. In essence, his finding is that if mean platelet volume (MPV) starts to rise, this is a sign of marrow cell recovery and impending (within the next two days) rise in platelet count. The report was given by J. David Bessman, MD, of the University of Texas Medical Branch at Galveston during the recent meeting of the American Society for Clinical Investigation in Washington, DC. The key to Bessman's method lies in a simple chart or nomogram (Figure, next page) developed from data easily obtained from the new generation of automatic blood cell counters. These counters now routinely provide MPVs as well as platelet counts. Previously, in a study of 683 normal subjects, Bessman showed that
THE RELATION OF CHLORIDS TO EDEMA.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Report of the Surgeon - General of the Army for the Fiscal Year Ending June 30, 1889.
Journal: JAMA (1890)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Association of prior infection with Chlamydia pneumoniae and angiographically demonstrated coronary artery disease
Authors: D. H. Thom
Journal: JAMA (1992)

<h3>Objective.</h3> —To evaluate the association between prior infection with<i>Chlamydia pneumoniae</i>, as measured by IgG antibody, and coronary artery disease. <h3>Design.</h3> —A population-based, case-control study. <h3>Setting.</h3> —Group Health Cooperative of Puget Sound, a Seattle-based health maintenance organization. <h3>Participants.</h3> —Men 55 years of age and younger and women 65 years of age and younger. Cases (n=171) were members of Group Health Cooperative undergoing diagnostic coronary angiography who had at least one coronary artery lesion occupying 50% or more of the luminal diameter. The population controls (n=120) were Group Health Cooperative members without known coronary heart disease. <h3>Main Outcome Measure.</h3> —The adjusted odds ratio (OR) for coronary artery disease associated with prior<i>Cpneumoniae</i>infection as measured by the presence of IgG antibody. <h3>Results.</h3> —After adjusting for age, gender, and calendar quarter of blood drawing, the OR for coronary artery disease associated with the presence of antibody was 2.6 (95% confidence interval, 1.4 to 4.8). The association was limited to cigarette smokers, in whom the OR was 3.5 (95% confidence interval, 1.7 to 7.0). Among never-smokers, the OR was 0.8 (95% confidence interval, 0.3 to 1.9). When cases and controls were restricted to those assayed concurrently, the adjusted OR (smokers and nonsmokers combined) was 4.2 (95% confidence interval, 1.8 to 10.0). Adjustment for serum cholesterol, hypertension, alcohol use, diabetes, and socioeconomic status did not change these results. Only a weak association was found when cases were compared with 63 subjects whose angiographic results were normal (OR, 1.2; 95% confidence interval, 0.6 to 2.2). <h3>Conclusions.</h3> —These results generally support the previously reported association between<i>Cpneumoniae</i>infection and coronary heart disease. However, caution should be used in interpreting the basis for this association. (<i>JAMA</i>. 1992;268:68-72)
Errors in Data Entry and Figures
Authors: Rishad Khan, Michael Scaffidi, Med Samir, C Grover, Samir Grover
Journal: JAMA Internal Medicine (2019)

Maria Panagioti, PhD; Keith Geraghty, PhD; Judith Johnson, PhD; Anli Zhou, MD; Efharis Panagopoulou, PhD; Carolyn Chew-Graham, MD; David Peters, MD; Alexander Hodkinson, PhD; Ruth Riley, PhD; Aneez Esmail, MD, PhD
Human Semen, Frozen and Stored in Liquid Nitrogen, Is Used Successfully by Clinical Investigators
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Experience in clinical lung transplantation
Authors: F. J. Veith
Journal: JAMA (1972)

Observations on two patients who received single lung allografts indicate that one transplanted lung can provide total gas exchange while carrying virtually the entire cardiac output at tolerable pulmonary-artery pressures (18 to 19 mm Hg), and that human lung allograft rejection can be reversed with corticosteroid treatment. Although the remaining emphysematous lung in one patient had high vascular resistance, compliance, and expiratory airway resistance, it appears that the resulting ventilation-perfusion imbalances did not produce serious respiratory insufficiency until allograft rejection further impaired transplant ventilation. Thus, better immunosuppression, rather than bilateral procedures, is a pressing need in lung transplantation.
A Manual of Anatomy.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Age at Cancer Diagnosis Among Persons With AIDS
Authors: Charlotte Sakarovitch, Eric Fontas
Journal: Annals of Internal Medicine (2011)

Letters3 May 2011Age at Cancer Diagnosis Among Persons With AIDSCharlotte Sakarovitch, PhD and Eric Fontas, MD, PhDCharlotte Sakarovitch, PhDFrom Department of Public Health, Nice University Hospital, 06202 Nice, France. and Eric Fontas, MD, PhDFrom Department of Public Health, Nice University Hospital, 06202 Nice, France.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-154-9-201105030-00012 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Shiels and colleagues (1) showed that age at cancer diagnosis is often similar in the AIDS population and the general population after adjustment for age differences. However, Martin and Volberding's related editorial (2) commented on the complexity of defining premature aging, and we will demonstrate that, in some cases, the same age at diagnosis can hide real differences.Let's denote IAIDS(a) and Igen(a) as the cancer incidence rates at age a among, respectively, the AIDS population and the general population. Shiels and colleagues stated that, after adjustment for age, "if HIV merely increases the risk for … ...References1. Shiels MS, Pfeiffer RM, Engels EA. Age at cancer diagnosis among persons with AIDS in the United States. Ann Intern Med. 2010;153:452-60. [PMID: 20921544] LinkGoogle Scholar2. Martin J, Volberding P. HIV and premature aging: a field still in its infancy [Editorial]. Ann Intern Med. 2010;153:477-9. [PMID: 20921548] LinkGoogle Scholar3. Bray F, Møller B. Predicting the future burden of cancer. Nat Rev Cancer. 2006;6:63-74. [PMID: 16372017] CrossrefMedlineGoogle Scholar4. Belot A, Grosclaude P, Bossard N, Jougla E, Benhamou E, Delafosse P, et al. Cancer incidence and mortality in France over the period 1980-2005. Rev Epidemiol Sante Publique. 2008;56:159-75. [PMID: 18547762] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Department of Public Health, Nice University Hospital, 06202 Nice, France.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAge at Cancer Diagnosis Among Persons With AIDS in the United States Meredith S. Shiels , Ruth M. Pfeiffer , and Eric A. Engels Age at Cancer Diagnosis Among Persons With AIDS Mari M. Kitahata , Chad J. Achenbach , and Michael S. Saag Age at Cancer Diagnosis Among Persons With AIDS Meredith S. Shiels , Ruth M. Pfeiffer , and Eric A. Engels Correction: Age at Cancer Diagnosis Among Persons With AIDS Metrics Cited ByCorrection: Age at Cancer Diagnosis Among Persons With AIDS 3 May 2011Volume 154, Issue 9Page: 642KeywordsAIDSAgingCarcinogenesisConflicts of interestHIVLung and intrathoracic tumorsStomach ePublished: 3 May 2011 Issue Published: 3 May 2011 CopyrightCopyright © 2011 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Propranolol inhibits cavernous vascular malformations by β1 adrenergic receptor antagonism in animal models
Authors: Wenqing Li, Robert Shenkar, Mathew R. Detter, Thomas Moore, Christian Benavides, Rhonda Lightle, Romuald Girard, Nicholas Hobson, Ying Cao, Yan Li, Erin Griffin, Carol Gallione, Joseph M. Zabramski, Mark H. Ginsberg, Douglas A. Marchuk, Issam A. Awad
Journal: Journal of Clinical Investigation (2021)
QuickStats: Percentage* of Adults Aged 18–64 Years Who Did Not Get or Delayed Medical Care in the Past Year Because of Cost,† by Type of Locality§ — National Health Interview Survey, 2012–2014¶
Journal: MMWR Morbidity and Mortality Weekly Report (2015)

This report details the National Center for Health Statistics' (NCHS) development of the 2006 NCHS Urban-Rural Classification Scheme for Counties and provides some examples of how the scheme can be used to describe differences in health measures by urbanization level. MethodsThe 2006 NCHS urban-rural classification scheme classifies all U.S. counties and county-equivalents into six levels-four for metropolitan counties and two for nonmetropolitan counties.The Office of Management and Budget's delineation of metropolitan and nonmetropolitan counties forms the foundation of the scheme.The NCHS scheme also uses the cut points of the U.S. Department of Agriculture Rural-Urban Continuum Codes to subdivide the metropolitan counties based on the population of their metropolitan statistical area (MSA): large, for MSA population of 1 million or more; medium, for MSA population of 250,000-999,999; and small, for MSA population below 250,000.Large metro counties were further separated into large central and large fringe metro categories using classification rules developed by NCHS.Nonmetropolitan counties were assigned to two levels based on the Office of Management and Budget's designated micropolitan or noncore status.The 2006 scheme was applied to data from the National Vital Statistics System (NVSS) and the National Health Interview Survey (NHIS) to illustrate its ability to capture health differences by urbanization level. Results and ConclusionsApplication of the 2006 NCHS scheme to NVSS and NHIS data shows that it identifies important health disparities among communities, most notably those for inner city and suburban communities.The design of the NCHS Urban-Rural Classification Scheme for Counties makes it particularly well-suited for assessing and monitoring health differences across the full urbanization continuum.
Neoadjuvant, biweekly, dose-dense chemotherapy with epirubicin and cyclophosphamide followed by docetaxel in primary breast cancer
Authors: E.-M. Cramer, C. Moers, V. Zarghooni, P. Mallmann, M. Warm
Journal: Journal of Clinical Oncology (2005)

820 Background: Neoadjuvant (primary systemic) chemotherapy achieves similar survival benefits to adjuvant therapy in patients with locally advanced breast cancer, with the potential of predicting clinical response and increasing the rate of breast-conserving surgery (BCS). Encouraged by results from recent studies of dose-dense chemotherapy in the adjuvant setting, we studied preoperative treatment with biweekly epirubicin and cyclophosphamide followed sequentially by biweekly docetaxel. Methods: Main inclusion criteria for this prospective Phase II study were: tumor size >2 cm, no distant metastases and age 18–65 years. Patients with locally advanced breast cancer received epirubicin 90 mg/m2 plus cyclophosphamide 600 mg/m2 (q2w x 4 cycles) followed by docetaxel 75 mg/m2 (q2w x 4 cycles). PEGylated filgrastim was administered on Day 2 of the first 4 cycles to reduce the risk of neutropenic complications. Clinical and sonographic tumor examinations were performed every 2 cycles. The primary endpoint of this trial was clinical and pathologic response rate. Secondary endpoints were BCS rate and toxicity. Results: Between 01/2004 and 11/2004, 37 women (median age 51 [range: 30–65] years) with locally advanced breast cancer were enrolled. Baseline median tumor size was 3.17 [range: 2–10] cm. Pathologic complete response was observed in 9 patients (24.3%), sonographic partial response in 16 patients (43.2%), minimal response in 5 patients (13.5%), and stable disease in 6 patients (16.2%). One patient (2.7%) had progressive disease. The most common toxic event was grade 2 hand-foot skin reaction (NCI-CTC criteria), which occurred in 24 patients (67.5%). Two patients had grade 2 neutropenia (NCI-CTC criteria) and required hospitalization (after Cycles 5 and 8, respectively); treatment was discontinued in one patient after Cycle 6 due to poor physical condition. Conclusion: Neoadjuvant dose-dense biweekly epirubicin plus cyclophosphamide (with PEGylated filgrastim) followed sequentially by docetaxel was active in primary breast cancer, with acceptable toxicity and a low rate of neutropenic complications. This regimen warrants further investigation. No significant financial relationships to disclose.
Methadone treatment and acquired immunodeficiency syndrome
Authors: J. R. Cooper
Journal: JAMA (1989)

In light of the recent growth in public financial support for the rapid expansion of drug abuse treatment capacity, the unique effectiveness of methadone hydrochloride treatment in reducing intravenous opioid abuse and the associated sharing of injection equipment is reviewed and discussed, and its potential effect on preventing the spread of acquired immunodeficiency syndrome is examined. In addition to methadone, treatment variables that clinical research suggests are integral to effective treatment are identified. Methadone treatment is one of the most helpful means of reducing the risk of acquired immunodeficiency syndrome available, provided that programs of quality are expanded. The medical profession and universities are urged to take steps to ensure quality efforts in prevention and treatment. (<i>JAMA</i>. 1989;262:1664-1668)
Saccharin and cancer
Authors: G. R. Meneely
Journal: JAMA (1979)

<h3>In Reply.—</h3> The argument offered by Dr Schabel and his associates is persuasive only with the assumption that scans are always accurate. Unfortunately, as every clinician knows, that is not the case. As we noted in our article, the accuracy of scanning for the detection of metastases has been reported to be as low as 60% We stay with the conclusions suggested by our data that routine triple radionuclide scans of the bone, brain, and liver are not justified in patients with potentially resectable carcinomas of the lung.
Bacteriology. A Study of Microörganisms and Their Relation to Human Welfare, Discussing the History of Bacteriology, the Nature of Microörganisms and Their Significance in Connection with Pathology, Hygiene, Agriculture and the Industries.
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) in the Imatinib-Era: High Survival Rate Following Allogeneic HSCT after Imatinib Failure: Results of the German CML Study IV
Authors: Susanne Saussele, Michael Lauseker, Alois Gratwohl, Dominik Heim, Dietrich Wilhelm Beelen, Hartmut Döhner, Rainer Schwerdtfeger, Anthony D. Ho, Hans-Jochem Kolb, Markus Pfirrmann, Martin C. Müller, Armin Leitner, Ulrike Proetel, Elena Kovalevskaya, Claudia Haferlach, Brigitte Schlegelberger, Joerg Hasford, Andreas Hochhaus, Ruediger Hehlmann
Journal: Blood (2008)
Highlights from this issue
Authors: The Triumvirate
Journal: Thorax (2020)

Throughout the COVID-19 pandemic, UK politicians have claimed to "follow the science" -in some cases all the way from Durham to Barnard Castle… In this issue of Thorax the Triumvirate bring you the best science and follow it to some unexpected places: all the way from Manchester (community-based spirometry data) (see page 655) to the Antarctic (in the footsteps of Ernest Shackleton) (see page 693).
Geriatric Medicine
Authors: ROBERT L. DICKMAN
Journal: Annals of Internal Medicine (1982)

Letters and Corrections1 January 1982Geriatric MedicineROBERT L. DICKMAN, M.D.ROBERT L. DICKMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-96-1-121_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: It is certainly true that those of us who worry about the health care of elderly can, at times, suffer from missionary zeal in our attempts to seek converts. It is also true that the intergenerational competition for scarce medical resources is a serious dilemma facing our health care system. Nevertheless, Hanauer's recent letter (1) cannot go unchallenged.Hanauer would have us believe that deciding on no or minimal treatment for the chronic demented patient will help send kids to camp or encourage them to read. At the very least, such an assumption is naive. Further, it...Reference1. HANAUER L. Care for dementia. Ann Intern Med. 1981;95:391. Letter. LinkGoogle Scholar1. Geriatric medicine: a statement from the Federated Council for Internal Medicine. Ann Intern Med. 1981;95:372-6. LinkGoogle Scholar2. BUTLER R. The teaching nursing home. JAMA. 1981;245:1435-7. CrossrefMedlineGoogle Scholar3. DANSKERR PM. Education in geriatrics and gerontology. N Engl J Med. 1979;300:1399-400. Letter. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 January 1982Volume 96, Issue 1Page: 121-121KeywordsCyclic adenosine monophosphateElderlyGeriatricsHealth care Issue Published: 1 January 1982 PDF downloadLoading ...