tbuckley/cabot-search huggingface dataset:
Abstract 852: Bromodomain and extraterminal proteins regulate the epithelial-mesenchymal transition in breast cancer
Authors: Guillaume Andrieu, Gerald V. Denis
Journal: Cancer Research (2017)

Abstract The epithelial-mesenchymal transition (EMT) is a developmental program that cancer cells often activate to acquire a highly plastic phenotype that promotes invasion, metastasis, but also chemoresistance and cancer stem cell generation. As readers of epigenetic marks, bromodomain and extra-terminal (BET) proteins BRD2, BRD3 and BRD4 participate in the regulation of multiple transcriptional programs implicated in cancer progression. We sought to unravel the roles of BET proteins in EMT in breast cancer. Despite their homology, we report that BET proteins differentially regulate EMT. Based on an EMT PCR array, we identify a BRD2-specific transcriptional profile that promotes EMT, whereas BRD3 and BRD4 signatures repress this program. These individual signatures are unidentifiable upon pan-BET inhibition using JQ1, reinforcing the necessity to target each BET member separately to better understand their functions. Upon BRD2 depletion, basal-like breast cancer cells, which present a mesenchymal phenotype, exhibit a reduced expression of mesenchymal markers (N-cadherin, vimentin) and re-express epithelial markers (E-cadherin, cytokeratins). Moreover, a large panel of EMT master transcription factors is downregulated in BRD2-depleted cells, including the Snail and ZEB families or Twist. Interestingly, we found that BRD3 or BRD4 depletion leads to the opposite phenotype: an increase of mesenchymal marker expression and repression of the epithelial markers. In luminal A breast cancer cells which present an epithelial phenotype, BRD2 overexpression leads to the expression of mesenchymal markers. Similar results were obtained by depleting BRD3 or BRD4 in these cells, confirming the differential roles of BET proteins in EMT regulation. Taken together, our results establish that BRD2 positively regulates EMT, whereas BRD3 and BRD4 repress this program. BET proteins possess separate and opposite biological functions, reinforcing the relevance of an individual targeting instead of a pan-BET inhibition using JQ1. We hypothesize that BET proteins modulate EMT through the regulation of its master transcription factors. We propose that the balance of BET proteins presence at the promoters of the EMT genes is a novel mechanism of regulation of this program in breast cancer cells. Citation Format: Guillaume Andrieu, Gerald V. Denis. Bromodomain and extraterminal proteins regulate the epithelial-mesenchymal transition in breast cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 852. doi:10.1158/1538-7445.AM2017-852
Go with the Flow: An Updated Tool for Detecting Molecules
Authors: Lance Frazer
Journal: Environmental Health Perspectives (2000)

In the early 1970, researchers at Los Alamos National Laboratories developed the flow cytometer, a device that allows for the identification of unknown cells. In a flow cytometer, a single-cell suspension is passed in a continuous flow through a laser beam, with each cell scattering the light in a characteristic manner. A few years ago, researchers at Los Alamos began another project, refining the capabilities of the flow cytometer so that it could analyze not a single cell but a single molecule, allowing scientists to study bacteria at the molecular level, differentiating between individual strains more quickly and with greater accuracy than before. The new flow cytometer shows great promise in a variety of fields where single-molecule study would be valuable, such as genomics and disease transmission.
Avoidance of cows' milk is effective in infantile colic
Journal: BMJ (1998)

Cognitive behaviour therapy is promising in childhood depressive disorderOver the past 15 years there has been increasing recognition that children suffer depressive conditions.A systematic review concluded that tricyclics were of unproved benefit.On p 1559 Harrington et al present a systematic review of six trials of a common psychological treatment-cognitive behaviour therapy.The results suggest that it may be useful in mild or moderately severe cases of juvenile depression.Studies that compare cognitive behaviour therapy with antidepressant medication are now required.
A Study in Cocaine
Authors: David F. Musto
Journal: JAMA (1968)

Cocaine stimulated the early careers of two brilliant investigators, Sigmund Freud and Sherlock Holmes. In fact, their common attraction to the euphoric properties of the coca leaf may be more than a coincidence. But whatever the Freud-Holmes relationship, the cocaine episodes in each of their lives reflect the impact of a new psychic drug on literature and science. Some of their admirers may deny or overlook this aspect of their careers, thinking that any association with such a drug can only be an embarrassment. But the international enthusiasm for cocaine which antedated and extended beyond their periods of endorsement makes it unlikely that any fair-minded person will censure them. The cocaine episode illustrates how easily objective evaluation may be submerged by personal enthusiasm and how remarkably difficult it may be, in spite of vast amounts of evidence, to judge correctly a widely used drug. Perhaps a reason for delay in
The Dangers of LSD
Authors: J. Thomas Ungerleider
Journal: JAMA (1966)

The symptoms, diagnostic categories, and general characteristics of patients in 70 cases of adverse reactions to lysergic acid diethylamide tartrate (LSD) are varied. Psychiatric side effects ranged from depressive reaction to psychotic states. In all cases, LSD ingestion occurred separately and apart from medical-experimental and psychiatric-therapeutic models of LSD usage. Findings based on these cases and from observations made on LSD users in the community indicate that widespread use of LSD is a cause for concern.
JAMA 75 YEARS AGO
Journal: JAMA (1978)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Assessing deafness.
Authors: H Ludman
Journal: BMJ (1981)

Full assessment of a deaf patient demands specifying, for each ear, the site of the defect, the cause, and the severity of disability.When these can be stated, which is not always possible, an attempt can then be made to determine (a) whether the defect is treatable, with a possibility of improving hearing; (b) the overall disability, considering hearing in both ears, and (c) whether the deafness is a symptom of another disease-for example, syphilis or acoustic neuroma.Important aspects of the history include the rate of onset and progression, family history, any information about noise exposure or unusual medication and associated aural symptoms (pain, discharge, vertigo, and tinnitus).Examination will show whether the external ear canal is obstructed and, if not, the state of the ear drum.Obstructing wax or debris must be removed.The otologist generally removes it manually under the illumination of a headlight using wax hooks and rings, or cottonThe photograph of an operating microscope was reproduced by permission of Carl Zeiss (Oberkochen) Ltd and that of the audiometer by permission of Amplivox.
Contact Dermatitis
Authors: Gabe Mirkin
Journal: JAMA (1987)

John Stanbury wrote the book on metabolism, Robert Williams wrote the book on endocrinology, Goodman and Gilman wrote the book on pharmacology, and Alexander Fisher wrote the book on contact dermatitis. This is the bible of contact dermatitis and should be owned by every dermatologist. Dr Fisher, who is now 82 years old, has studied contact dermatitis throughout his career. In his book, he answers the following questions: What's the most common cause of swollen eyelids in a woman? (contact dermatitis, often from fingernail polish, p 77). Which vitamin is most likely to cause contact dermatitis? (thiamine, p 55). What's the most common sensitizing topical antibiotic? (neomycin, p 195). What gloves protect people who are allergic to nickel? (vinyl, not rubber, p 260). He presents a 67-page table of the common ingredients that cause contact dermatitis, where they are found, and their various cross reactants. He also includes the following
Abstract 919: Suppression of Abdominal Aortic Aneurysms in the Angiotensin II-infused ApoE Deficient Mice by Treatment with Chymase Inhibitor
Authors: Nao Inoue, Michiko Muramatsu, Denan Jin, Shinji Takai, Tetsuya Hayashi, Hiroshi Katayama, Hiroshi Tamai, Yasushi Kitaura, Mizuo Miyazaki
Journal: Circulation (2007)

Chymase promotes not only angiotensin II production but also matrix metalloproteinase (MMP)-9 activation, which have a critical role on development of abdominal aortic aneurysms (AAAs). The purpose of this study is to examine the effects of chymase inhibitor, NK3201, on the MMP-9 activity and development of AAA in the angiotensin II-induced apolipoprotein E (apoE)-deficient mice. Method: Angiotensin II (1000ng/kg/min) (vehicle group) or saline (control group) were infused into 16-week-old male apoE-deficient mice for 4 weeks. To examine the effect of chymase inhibition for AAA, we administered NK3201 (30mg/kg/day) to angiotensin II-infused group (NK3201-treated group) for the same period. At the end of angiotensin II infusion, we measured the diameters of suprarenal and infrarenal aorta. AAA severities were scored using the suprarenal aortic diameter/infrarenal aortic diameter ratio and presence of thrombus formation, i.e. under 2.0 was 0, from 2.0 to 2.5 was 1, from 2.5 to 3.0 was 2, over 3.0 was 3, and presence of thrombus was 4. We also determined the chymase and MMP-9 activities using total aorta. Results: The scores that reflected the progression and severity of AAA were increased in vehicle group compared with control group ( 2.35±0.30 vs. 0.27±0.12, p&lt;0.01). This progression was inhibited in NK3201-treated group compared with vehicle group (1.13±0.35, p&lt;0.05 vs. vehicle group). Chymase activity was significantly increased in vehicle group compared with control group. MMP-9 activity was also increased in vehicle group, however it was decreased significantly in NK3201-treated group.Discussion: We demonstrated that chymase inhibition could reduce AAA progression through inhibition of MMP-9 in angiotensin II-induced apoE-deficient mice. Chymase inhibitor might be a novel strategy for preventing AAAs.
INTESTINAL ANASTOMOSIS.
Authors: J. HENRY BARBAT
Journal: JAMA (1899)

The question as to which method of intestinal anastomosis is the best is still unsettled; each deviser of a new method claiming his method or device to be superior to all others. Not having any method or device of my own I have endeavored to find out which was the most feasible for the use of the average surgeon; and also to determine which gave the best results. A method which requires extraordinary skill and a large amount of practice to perfect is not a feasible one for the average operator. With regard to results the case is different; we can demonstrate the difference between the results attained by the various methods by removing the specimens and subjecting them to microscopic examination. The ideal result would be the accurate apposition of the respective layers of the intestine without the interposition of any scar tissue; therefore the nearer we approach this
Mass Radiography
Authors: J. G. Bancroft
Journal: BMJ (1970)

almost without exception these departments were barely able to cope with their present work-load.To deal with the extra examina- tions at present made by one mobile x- ray unit much additional x-ray equipment and staff would be required.The mass radiography service should be kept under review to ensure that the best use is made of equipment and staff, but decisions as to its future must depend upon adequate consultation with those running the units and those responsible for the individual hospital radiographic departments in the area.It can only be by such consultation that an efficient chest x-ray service will be provided.-Iam, etc.,
Hourly Prompts Reduce Workers’ Time Spent Sitting
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cooperative study of hospital frequency and character of transient ischemic attacks. I. Background, organization, and clinical survey
Authors: M. L. Dyken
Journal: JAMA (1977)

To better understand transient ischemic attacks (TIA), all patients (1,328) with TIA-like symptoms were identified at six participating institutions representing known variations in geography, referral patterns, and socioeconomic status. A total of 954 patients were observed for a mean of 14.3 months. Problems in diagnosis are defined, demographic information is summarized, and features of the history, examination, tests, and treatments are noted. (<i>JAMA</i>237:882-886, 1977)
P-198 Circulating microRNAs in metastatic colorectal cancer (mCRC) patients (pts) treated with regorafenib
Authors: M. Schirripa, F. Loupakis, C. Cremolini, L. Poliseno, L. Salvatore, A. Tuccoli, C. Antoniotti, R. D'Aurzio, F. Marmorino, B. Borelli, D. Rossini, A. Saettini, S. Gini, R. Moretto, I. Rizzo, E. Dell' Aquila, M. Pellegrini, A. Falcone
Journal: Annals of Oncology (2015)
Lincoln-Marfan Debate
Authors: J. Willard Montgomery
Journal: JAMA (1971)

<h3>To the Editor.—</h3> My next and last contribution to the Lincoln-Marfan Debate will be in the form of an illustrated, booklength manuscript, as yet unpublished, entitled<i>Flibbertigibbet: The White House Baby Sitter</i>. Therein the true Lincoln is described without political overtones or figments of imagination of a self-appointed historian. It is hard to believe the material it contains has been passed over by so many for so long, but consoling in that it took me 25 years to find it. I did not really find it. Donna Griffitts, a young lady of remarkable talents who is librarian to the Surgeons General of the Army and Air Force and a long time friend, dug it out for me. This is not the first time she has bailed me out of a tight spot. In a retrospect, my "refutation proclamation," as one of my opponents in the Debate considered it, was a
INTESTINAL MOVEMENTS
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Updating the British Society for Cutaneous Allergy Facial Series to ensure accurate diagnosis of allergic contact dermatitis
Journal: British Journal of Dermatology (2021)

Allergic contact dermatitis (ACD) is a localised form of dermatitis or eczema which occurs 48‐72 hours after a substance which causes allergy (an allergen) has been in contact with the skin. It affects 20% of people. ACD to cosmetics is widely reported, with facial eczema being the main presenting complaint.
Active Histoplasma meningitis of 22 years' duration
Authors: J. A. Gelfand
Journal: JAMA (1975)

HISTOPLASMA meningitis without infection of other organs is an exceedingly rare disease. We have had the opportunity to follow-up a case of<i>Histoplasma</i>meningitis, previously reported 11 years ago,<sup>1</sup>that has now been active for 22 years without major sequelae, a degree of chronicity unique for meningeal infection due to any cause. This case suggests that histoplasmosis that is confined clinically to the meninges may follow a much more chronic course than<i>Histoplasma</i>meningitis with other organ involvement. <h3>Report of a Case</h3> A 58-year-old man was first hospitalized in 1952 for severe headaches. Lumbar puncture and analysis of cerebrospinal fluid (CSF) disclosed an elevated protein level, lymphocytosis, and hypoglycorrhachia. Cultures on this and on subsequent admissions were negative until 1959, when culture of 30 ml of CSF, removed during pneumoencephalography, was positive for<i>Histoplasma capsulatum</i>. Physical examination, roentgenograms, and cultures from multiple sites, including sputum, blood, urine, and bone
Estrogen Receptors
Authors: Lynn E. Posey
Journal: JAMA (1977)

<h3>To the Editor.—</h3> Care should be taken in using the "Estrogen Receptor Assay in the Differential Diagnosis of Adenocarcinomas," as proposed by David T. Kiang, MD, PhD, and B. J. Kennedy, MD (238:32, 1977). Stating that estrogen receptor of the 8S type was found only in adenocarcinoma of the breast, uterus, and ovary, they suggested that that fact could be used to evaluate cancers of unknown origin in female patients. However, they examined only a limited number of tissues other than breast. We have also analyzed neoplastic tissues from sites other than the breast for estrogen receptors. The Table summarizes our data. Both the dextrancoated charcoal<sup>1</sup>and the sucrose gradient<sup>2</sup>methods were used. Tissues were considered positive for estrogen receptors only if they bound at least 6 femtomoles or more of 3H-estradiol per milligram of cytosol protein. We found these percentages of positive tissues: breast, 40%; melanoma, 21%;
Book Review Health Resorts of the U. S. S. R.: A symposium of articles . Compiled from data of the Central Institute of Balneology in Moscow. Editor: Dr. I. A. Pertsov. 8°, cloth, 270 pp., with 45 illustrations. Moscow, Russia: The U. S. S. R. Society of Cultural Relations with Foreign Countries (V. O. K. S.).
Journal: New England Journal of Medicine (1942)
Mortality in a Region Surrounding an Arsenic Emitting Plant
Authors: Goran Pershagen, Carl-Gustaf Elinder, Anne-Marie Bolander
Journal: Environmental Health Perspectives (1977)

The purpose of the investigation is to study whether an increased mortality from certain causes exists in an area around the Rönnskärsverken smelter works in northern Sweden. Founded in 1928, this metallurgical plant processing mainly nonferrous metals has since its initial operations been using ore with a high arsenic content. This has resulted in environmental pollution to air and water of arsenic, as well as other metals and sulfur dioxide. The causes of death for the population of two parishes in the vicinity of the plant were listed from the National Sedish Register on Death Causes. A reference area in the same part of Sweden with similar degree of urbanization, occupational profile, and age distribution was chosen. The causes of death for the two populations were followed during a period of 14 yr. A significantly higher mortality rate for lung cancer was noted in men in the exposed area. However, this increase was no longer significant when the occupationally exposed at Rönnskärsverken were excluded. The latter showed a highly significant excess mortality due to primary respiratory cancer. A continuation of this investigation in the form of a cohort study of both the mortality and cancer incidence is currently under way.
Transactions of the Medical and Chirurgical Faculty of the State of Maryland.
Authors: None C. E. W.
Journal: JAMA (1884)

This contribution to medical literature contains very little trash. In glancing over its pages the following items have attracted our attention. The recommendation of C. W. Chancellor,M.D., respecting the sanitary needs of the poor, expresses the hope that in time the laboring classes may be in possession of better dwellings, and recommends means for securing this and other desirable results. A paper on "Preventable Blindness," by Samuel Theobald, M.D, particularly cautions the profession respecting the several varieties of ophthalmia, including sympathetic, and glaucoma. F. Donaldson, M.D., respecting the influence of lung retractility, concludes that it is "not only a powerful physiological force in respiration, but that it also produces modification of a decided character in diseases of the chest." This latter is of particular importance in making a physical diagnosis.