tbuckley/cabot-search huggingface dataset:
European Perspectives
Authors: Faiez Zannad, Jennifer Taylor, Sleeping Beauty-Spironolactone, Bojan Vrtovec, Lale Tokgözoğlu, Jean René, Nancy Zannad
Journal: Circulation (2008)

in 1986.Both theses focused on biochemical monitoring of digitalis activity.Professor Zannad describes the principal mentor in his career, Professor Graham-Smith, as a "true clinical pharmacologist," the specialty having originated
S59 Using venous blood gas analysis in the management of COPD exacerbations; a prospective cohort study
Authors: DE Shaw, AM Kelly, G Housley, G Hearson, C Reynolds, TW Harrison, TM McKeever
Journal: Thorax (2015)

<h3>Introduction</h3> COPD exacerbations are a common cause of emergency hospital admission in the UK, with an estimated 94,000 per year. Identifying hypercapnic respiratory failure is crucial. Guidelines recommend obtaining arterial blood samples but these are more difficult to obtain than venous samples. Furthermore, administration of local anaesthetic prior to arterial sampling is seldom used. We assessed whether blood gas values derived from venous samples could replace arterial at initial assessment. <h3>Methods</h3> Patients treated for a COPD exacerbation had paired arterial and venous samples taken. Bland Altman analyses were performed to assess agreement between arterial and venous pH, PCO<sub>2</sub> and HCO<sub>3</sub><sup>-</sup>, and between SpO<sub>2</sub> and SaO<sub>2</sub>. The number of attempts and pain scores for each sample were measured. <h3>Results</h3> 234 patients had paired arterial and venous samples. There was good agreement between arterial and venous measures of pH and HCO<sub>3</sub><sup>-</sup> (mean difference 0.03 and -0.04, limits of agreement -0.54 to 0.11, and -2.90 to 2.82), and between SaO<sub>2</sub> and SpO<sub>2</sub> (in patients with a SpO<sub>2</sub> of greater than 80%). We calculated the sensitivity and specificity of a VBG pH and HCO<sub>3</sub><sup>-</sup> to correctly identify an arterial pH of ≥7.35, and an arterial HCO<sub>3</sub><sup>-</sup> of ≥21, as well as a SpO<sub>2</sub> to identify a SaO<sub>2</sub> of ≥ 92%. A venous pH of 7.34, a venous HCO<sub>3</sub><sup>-</sup> of 21.45 and a SpO<sub>2</sub> of 91.5 would have correctly classified 87% (95% CI 82% to 91%), 97% (95% CI 93% to 98%), and 71% (95% CI 65% to 77%), of patients respectively. 96% of patients with an ABG pH of ≥7.35 also had a VBG pH of ≥7.35. Arterial sampling took more attempts and was more painful than venous (mean pain score 4 (IQR 2–5) and 1 (IQR 0–2), p &lt; 0.001). <h3>Conclusion</h3> Arterial sampling is more difficult and painful than venous sampling. There is good agreement between pH and HCO<sub>3</sub><sup>-</sup> values derived from venous and arterial blood, and between pulse oximetry and arterial blood gas oxygen saturations. This could allow the initial assessment of COPD exacerbations to be based on venous blood gas analysis and pulse oximetry, simplifying the care pathway and improving the patient experience.
SOME NEW LIGHT ON THE CAUSATION OF IDIOPATHIC TETANUS.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Use of intracavitary contrast media in patients with neoplastic effusions
Authors: A. J. Piro
Journal: JAMA (1968)

Instillation of water soluble contrast media into the pleural, peritoneal, or tumor cavities of 24 patients with neoplastic effusion was demonstrated to be a simple, safe, and useful technique. The determination of the extent of intracavitary loculation was reasonably accurate if care was exercised in the placing of the needle or catheter, if an adequate volume of dye was used, and if the patient's position was manipulated to insure adequate mixing of dye in the serous fluid. Since this method may be used to assure the correct position of the needle or catheter and to confirm adequate distribution, serious local reactions secondary to the use of intracavitary radioactive compounds or vesicant drugs may be avoided. Large intracavitary masses were demonstrated by this technique, but small tumors were not seen easily.
FRACTURED CLAVICLES
Authors: T. K. Richards
Journal: JAMA (1922)

The method here advocated is a slightly modified clavicular cross, or T splint. The cross as commonly applied is made of ordinary splint wood with two widths of board forming the upper bar of the T across the shoulders, with the long arm of the T extending to the lower thoracic vertebrae, the whole splint being carefully padded and held in place by sheet wadding and bandages or webbing straps binding each shoulder tightly to the outer end of the double boards. The lower end of the T is held to the back in a similar manner. The changes are the result of treating fifty fractured clavicles, and are that: 1. The width of the cross bar of the T is of a width corresponding to the width of the shoulder at the axilla (that is, the distance from the superior aspect of the shoulder to the lower edge of
OSTEOTOMY.
Authors: DeFOREST WILLARD
Journal: JAMA (1899)

This operation, though a simple one and productive of the most excellent results, is, I fear, too little appreciated by the general practitioner, and even by surgeons. There is no more satisfactory operation in surgery, nor one that is applicable to such a variety of conditions. It is safe, speedy, easily performed, seldom followed by any unpleasant consequences, and most effective in relief. Although it is one of the most common operations in my hands, I can safely say that I have not, for ten years, had a single drop of pus following its performance. To accomplish this desirable end, however, it is necessary that the surgeon shall be absolutely cleanly, and that he shall not introduce into the wound any elements of suppuration. The application of the operation is wide; in deformities following fractures; in ankyloses of joints, from whatever cause; in the distortions of bone produced by rickets,
SOCIETY NEWS.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Alcohol's Impact on Fetal CNS
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Influenza Vaccine for 2018-2019
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction
Authors: H Reddel, M Gerhardsson De Verdier, A Agustí, R Beasley, E Bel, C Janson, B Make, R Martin, I Pavord, D Postma, D Price, C Keen, A Gardev, S Rennard, A Bansal, L Brannman, N Karlsson, J Nuevo, F Nyberg, S Young, J Vestbo
Journal: Thorax (2017)
CME Forum
Journal: JAMA (1991)

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Intermediary Metabolism
Authors: Claude A. Villee
Journal: New England Journal of Medicine (1954)

IN the past decade biochemists have turned more and more from analyses of the static condition of tissues to a consideration of the dynamics of tissue metabolism. This has been made possible by the availability of isotopes, both heavy and radioactive, and by the development of accurate and reliable methods of working with them. Biochemists have had to adapt the standard methods of organic syntheses to a microscale and to devise new methods for the synthesis of compounds labeled in a particular atom of the molecule. Still other methods have been discovered for the degradation of the products of metabolism . . .
P03.11 Finding a predictive marker for compliance to TTFields therapy - the comptune study
Authors: M A Proescholdt, A Haj, C Doenitz, A Brawanski, A Mühlberger, M Schmidmeier
Journal: Neuro-Oncology (2019)

Abstract BACKGROUND Tumor Treating Fields (TTFields) imply the administration of alternating electric fields to induce mitotic arrest in Glioblastoma (GBM) cells. Based on the specific mode of action, which requires continuous exposure of the malignant cell pool to TTFields, compliance to TTFields treatment is a crucial parameter for treatment success. Correspondingly, a recent post hoc analysis of the EF-14 trial has demonstrated a strong correlation between TTFields compliance rate and treatment success. However, there is currently no data regarding predictive factors for individual compliance rate. We are therefore performing a prospective study designed to analyze specific parameters potentially influencing compliance to TTFields treatment employing a standardized psychological assessment battery in GBM patients who choose or not choose to undergo TTFields treatment in a longitudinal fashion. The results of the psychological profile will be correlated to the compliance rates of the individual patients. MATERIAL AND METHODS Forty adult patients treated for newly diagnosed GBM at the University Regensburg Medical Center will be recruited. The psychological assessment battery aims at assessing four categories relevant for treatment compliance: 1. Lack of communicative skills, 2. depressive and anxiety disorders, 3. interpersonal factors (e.g. social support), and 4. intrapersonal factors, (e.g. beliefs about benefit, self-efficacy). The study endpoints are: 1. willingness to undergo TTFields therapy and 2. compliance rate of the individual patient, provided by the technical support team. The first interview takes place after treatment consultation (T0), 2 weeks after diagnosis (T1), at the initiation of TTFields treatment (T2) and every 4 weeks during treatment either until second disease progression or after maximal 8 months observation time per patient. Additionally, demographic (gender, age, marital status), clinical (KPI, extent of resection) and biological factors (MGMT promoter status, IDH1 mutation) will be assessed. RESULTS The study has been approved by the local ethics committee and has recruited the first 23 patients within 8 months since initiation of the study. The most updated results will be presented at the meeting. CONCLUSION One of the most challenging aspects in the application of TTFields in clinical practice is the identification of influencing factors increasing patients’ compliance. This study is designed to provide a psychological profile predictive for high treatment compliance.
Effect of Small Dose of X-Radiation on Local Recurrence of the Walker 256 Rat and C3H Mouse Tumors
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Molecular Cytogenetic Characterization of a Critical Region in Bands 7q35-q36 Commonly Deleted in Malignant Myeloid Disorders
Authors: Konstanze Döhner, Jill Brown, Ute Hehmann, Claudia Hetzel, Janet Stewart, Gordon Lowther, Claudia Scholl, Stefan Fröhling, Antonio Cuneo, Lap C. Tsui, Peter Lichter, Stephen W. Scherer, Hartmut Döhner
Journal: Blood (1998)
Diuretics Shift Circadian Rhythm of Blood Pressure From Nondipper to Dipper in Essential Hypertension
Authors: Takashi Uzu, Genjiro Kimura
Journal: Circulation (1999)

Background —Recently, we found that sodium restriction shifted the circadian rhythm of blood pressure from nondipper to dipper in patients with the sodium-sensitive essential hypertension. This study examined whether diuretics can transform the circadian rhythm of blood pressure from nondipper to dipper. Methods and Results —We studied 21 patients with essential hypertension during both a baseline period and a period of treatment with hydrochlorothiazide (25 mg daily). The periods lasted 4 weeks each. Twenty-four hour ambulatory blood pressures were measured on the same day of the week at the end of the each period. In nondippers (n=11), but not in dippers (n=10), a significant interaction existed between diuretic therapy and nocturnal fall in systolic and diastolic blood pressure, which indicated that the degree of nocturnal blood pressure fall was affected by diuretic therapy. Nocturnal fall, which was diminished in nondippers, was restored by diuretic therapy with hydrochlorothiazide, indicating that the circadian rhythm of blood pressure shifted from nondipper to dipper patterns. Conclusions —The present study demonstrated that diuretics can restore nocturnal blood pressure decline in a manner similar to sodium restriction, which suggests that the kidneys and sodium metabolism may play important roles in the genesis of the circadian rhythm of blood pressure. Diuretic-based treatment may have an additional therapeutic advantage of reducing the risk for cardiovascular complications by transforming the circadian rhythm of blood pressure.
Correction: Whooping-cough Immunization
Journal: BMJ (1947)

MMICALJOURNAV 32&plug should not be pushed into the tooth-socket but only placed over it, as prevention of the normal clot forming in the socket inevitably leads to sepsis, sequestration of the bony walls, and delaved healing.Cooking Eggs and Salmonella Q.-Yoiu puiblished (Oct. 19, 1946, p. 583) ani annijotatioln about ilie danlger of infection of dried egg powder by sal- tnonella organisms.Is there any method of cooking which uwill neutralize this danger ?A.-Salmonella organisms have the usual susceptibility of non-sporogenous bacteria to heat; that is to say, at 550 C. they are killed within 30 minutes, and at higher temperatures in proportionally shorter periods, survival at over 700 C. being measured in seconds rather than in minutes.The following
Annals of Physical Medicine, London
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TYPHOID ON THE PACIFIC COAST.
Journal: JAMA (1903)

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