tbuckley/cabot-search huggingface dataset:
A Study of the Relationship between Cadmium Concentrations in Urine and Renal Effects of Cadmium
Authors: Koji Nogawa, Etsuko Kobayashi, Ryumon Honda
Journal: Environmental Health Perspectives (1979)

The relationship between urinary cadmium concentration expressed as microgram/g creatinine and renal effects of cadmium exposure was studied in 542 inhabitants over 20 years of age who lived in the Jinzu River basin which is polluted by cadmium. Cadmium concentration in urine was employed as the index of cadmium exposure. Total protein with glucose, beta 2-microglobulin, retinol binding protein, and proline served as indices of renal effects. The prevalent rate of high beta 2-microglobulin excretion was the highest among these indices both in men and women. Prevalence rates of indices of renal effects increased proportionally with increasing cadmium concentrations in urine and probit linear regression lines could be calculated between them. The urinary cadmium concentrations corresponding to 1% prevalence rates of indices of the renal effects were calculated by the regression line. For beta 2-microglobulin, 3.2 microgram Cd/g creatinine and 5.2 microgram Cd/g creatinine were obtained in men and women, respectively. This method may be useful for evaluating the risk of renal damage of exposed inhabitants.
BEHAVIOR OF BLOOD PRESSURE DURING THE USE OF THE STOMACH TUBE
Journal: JAMA (1921)

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Lehrbuch der Speziellen Psychiatrie für Studierende und Aerzte.
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
HEALTH OF HAVANA.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
EXPERIENCE COUNTS FOR PROSTATECTOMY EFFICACY
Journal: CA A Cancer Journal for Clinicians (2007)

I've done a series of antismoking studies among adolescents, and I found that parental monitoring is indeed important," says Paek. "And more important sometimes than media campaigns.It makes sense because parents are a more important socialization medium."Parents need to talk to their kids about not smoking, she says.Doctors also can talk to their young patients about not smoking, keeping in mind that peer influence is a strong motivator for teens who smoke.
ERCP – Pancreatic
Authors: F. Fumex, T. Ponchon
Journal: Endoscopy (2008)

This prospective controlled multicenter trial studied the placement of 5-Fr plastic pancreatic stents to prevent pancreatitis following endoscopic retrograde cholangiopancreatography (ERCP). A total of 201 consecutive patients who required ERCP (excluding those with pancreatic cancer, pancreas divisum, and those requiring pancreatic duct drainage) were randomized into a stent placement group (n = 98) and a nonstent placement group (n = 103). The success rate of pancreatic stent placement was 96 %, and the rate of spontaneous dislodgement at day 3 was 95.7 %. The primary end point was rate of post-ERCP pancreatitis, which was lower in the stent group (3/94, 3.2 %) compared with the nonstent group (14/103, 13.6 %) (P = 0.019).
Euthanasia
Authors: J P Wight
Journal: BMJ (1988)

It is strange that Dr Forsvthe should ask why it takes the secretary of state a vear to determine an appeal under section 190 when the issues are so much weightier.)isciplinary pro- ceedings may arise from a clash of personalities.-Whatever the result of the current deliberations between the DHSS and the Joint Consultants Committee, the lMN6I )112 or similar procedure would lose some of its unf:airness if regional health authorities were stripped of their responsibilitics.if onlv becausc thcv do not tollow the fundamental principles of natural justice in which the accused consultant is told who his accuser is. FEILIX WEALE Shorne, KentDawsorn Jj [Ihti Savage case: the wider iVaseuv.Br tled '7
Medical Organization
Authors: T. F. Kittrell
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
REAMPUTATION
Authors: W. A. Chapple
Journal: BMJ (1917)

The following is the report of the condition of the kidney:This shows a con(lition of focal nephritis with evidence of several acute attacks recent in date.Capsule tlhickened in patches.Blood vessels do not show arterio-sc!erotic changes.. Glomeruli normal in places; in others they show capsular fibrosis and fibrosis or atrophy of glomeruli; elsewhere there are intracapsular exudation, cell proliferation, and fibrosis.The iinterstitial tissue is increased -in p itches, and containis maniy areas of lymphatic spaces laden with fat.
Abstract 590: Increased Endoplasmic Reticulum Stress in Atherosclerotic Plaques Associated With Acute Coronary Syndrome
Authors: Masafumi Myoishi, Testuo Minamino, Masafumi Kitakaze
Journal: Circulation (2007)

Background Endoplasmic reticulum (ER) responds to various stresses by up-regulation of ER chaperones, and prolonged ER stress eventually causes apoptosis. Although apoptosis is considered to be essential for the progression and rupture of atherosclerotic plaques, the influence of ER stress and apoptosis on rupture of unstable coronary plaques remains unclear. Methods and Results We obtained 152 coronary artery segments at autopsy and 40 atherectomy specimens from 71 and 40 patients, respectively . Smooth muscle cells (SMCs) and macrophages in the fibrous caps of thin cap atheroma and ruptured plaques, but not in the fibrous caps of thick cap atheroma and fibrous plaques, showed a marked increase in the expression of ER chaperone and numbers of apoptotic cells. ER chaperones also expressed higher in atherectomy specimens from patients with unstable angina pectoris than with stable angina. To explore the plausible molecular mechanism of activation of ER stress and the mechanistic link to apoptosis, we investigated plaque lipids such as oxysterols. Among oxysterols, expression of 7-ketocholesterol was increased in the fibrous caps of thin cap atheroma compared with thick cap atheroma. Treatment of either cultured coronary artery SMCs or THP-1 cells with 7-ketocholesterol induced upregulation of ER chaperones and apoptosis, while these changes were prevented by antioxidants. We also investigated possible signaling pathways for ER-initiated apoptosis and found that the CHOP (a transcription factor induced by ER stress)-dependent pathway was activated in unstable plaques. In addition, knockdown of CHOP expression by siRNA decreased ER stress-dependent death of cultured coronary artery SMCs and THP-1 cells. Conclusions Increased ER stress occurs in unstable plaques. Our findings suggest that ER stress-induced apoptosis of SMCs and macrophages may contribute to plaque vulnerability.
Apparent Correlation between Structure and Carcinogenicity of Phenylenediamines and Related Compounds
Authors: Harry A. Milman, Cheryl Peterson
Journal: Environmental Health Perspectives (1984)

The carcinogenicity of 23 phenylenediamines and related compounds was reviewed. An extensive analysis of the methods used indicated that the bioassays were conducted well. The data suggest that the carcinogenicity of 4-substituted 1,3-phenylenediamines is reduced substantially or eliminated completely by oxidation of one or both amine groups or by N-substitution. Oxidation of a methyl substituent on nitroaniline to a carboxyl group eliminated all carcinogenic activity. It required dichlorination to make ring-substtuted 1,4-phenylenediamine carcinogenic whereas only one chlorine atom was needed to make 1,2- and 1,3-phenylenediamine carcinogenic. While the available data suggest that as a class, 4-substituted 1,3-phenylenediamines are carcinogenic more often than ring-substituted 1,4-phenylenediamines, the type of added substituent and its position on the benzene ring also are important in exerting carcinogenic activity.
Error in Drug Nomenclature.
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
静脉注射免疫球蛋白用作顽固性坏疽性脓皮病的辅助疗法:病例和病例系列的系统性评述
Authors: H. Song, N. Lahood, A. Mostaghimi
Journal: British Journal of Dermatology (2018)

坏疽性脓皮病是一种罕见的皮肤问题,患者的白血球和中性粒细胞渗透皮肤,从而导致坏死和溃疡。由于早期治疗主要采用用于降低此种损害的逻辑方法,因此医生们尝试了各种不同的治疗方法,包括通过静脉注射使用免疫球蛋白(IVIG),一种从含有抗体的血浆中提取的蛋白质。此项研究利用此技术检查了此前发布的研究。研究的作者来自哈佛大学和美国波士顿的医院,他们寻找了49名在其他疗法(例如口服皮质类固醇和环孢霉素)无效后接受了这种治疗以改变疾病状况的患者。大部分患者至少患有一种基础疾病,包括癌症或炎性肠病(例如溃疡性结肠炎)。皮肤损伤影响了不同的身体部位,例如下肢或躯干。在大多数病例中,患者在接受IVIG治疗的同时也会口服皮质类固醇。使用IVIG加类固醇的疗法对半数以上患者完全有效,剩余患者中,有相当数量的患者有部分功效。最常见的副作用是恶心或头痛,但也存在皮疹和发烧等症状。总的来说,这些结果表明,对其他治疗药物无反应的患者来说,这可能是一种有效的疗法。
&lt;TITLE&gt;How Do I Know If I'm Pregnant?&lt;/TITLE&gt;
Journal: JAMA (2001)

The JAMA Patient Page is a public service of JAMA.The information and recommendations appearing on this page are appropriate in most instances, but they are not a substitute for medical diagnosis.For specific information concerning your personal medical condition, JAMA suggests that you consult your physician.This page may be reproduced noncommercially by physicians and other health care professionals to share with patients.Any other reproduction is subject to AMA approval.
Assessment of Health-Related Needs After Tsunami and Earthquake—Three Districts, Aceh Province, Indonesia, July-August 2005
Journal: JAMA (2006)

On December 26, 2004, an earthquake measuring 9.2 on the Richter scale off the northwest coast of the island of Sumatra, Indonesia, produced a tsunami that caused the deaths of an estimated 230,000 persons in India, Indonesia, the Maldives, Somalia, Sri Lanka, and Thailand. The majority of casualties were in Aceh Province (population 4.5 million) in northern Sumatra, Indonesia, where an estimated 130,000 persons died. In addition, 500,000 persons were displaced from their homes, and 37,000 remain unaccounted for in the province. In the Aceh Province districts of Banda Aceh and Aceh Besar, an estimated 90,000 persons died; approximately 75% of health workers in Banda Aceh either died or were displaced from their homes. On March 28, 2005, a second major earthquake, measuring 8.7 on the Richter scale, caused large-scale damage to the islands of Simeulue and Nias off the western Sumatra coast; approximately 300 persons died, and thousands were displaced. The international community responded to these events with the largest relief measures ever undertaken for a natural disaster. To determine the health and nutrition status of the affected populations and to evaluate the effectiveness of relief interventions 7 months after the tsunami and 3 months after the second earthquake, Cooperative for Assistance and Relief Everywhere, Inc. (CARE) International Indonesia and CDC conducted surveys in three districts of Aceh Province (Aceh Besar, Banda Aceh, and Simeulue). This report summarizes the results of those surveys, which identified routine vaccinations and provision of toilets or latrines as particular areas for improvement and revealed no significant difference in health indicators between internally displaced persons (IDPs) and nondisplaced populations. The relief response in Aceh Province should target areas needing improvement with programs that serve both IDPs and nondisplaced persons, as measures are implemented to rebuild the public health infrastructure.
Abstract 2816: 2′-Hydroxyflavanone inhibits lung cancer growth by inhibiting tumor cell proliferation and angiogenesis
Authors: Sharad S. Singhal, James Figarola, Jyotsana Singhal, Lokesh Nagaprashantha, Sanjay Awasthi
Journal: Cancer Research (2015)

Abstract Lung cancer remains the number one cause of cancer mortality in the US. Although systemic chemotherapy and novel biologic agents have been shown to improve survival, toxicities are often severe and effective preventive therapy has not been defined. Intake of flavonoids from citrus fruits has been shown to decrease the risk of lung cancer in large scale epidemiologic studies. Hence, we studied the biologic anti-lung cancer effects of 2HF, a naturally occurring compound in citrus fruits. Our in-vitro investigations revealed that 2HF inhibits the growth of bronchogenic adeno-, squamous and small cell lung carcinoma. This was associated with G2/M arrest, collapse in mitochondrial membrane potential (Δψm), and apoptosis. We demonstrated a down-regulation of fibronectin and key signaling proteins of the PI3K pathway. RLIP76 expression was significantly reduced by 2HF, and the survival as well as 14C-DOX transport on purified reconstituted-proteoliposomes prepared from H1618 and H358 cells was significantly inhibited, an effect which was synergistic with anti-RLIP76 IgG. Our in-vivo studies in mice xenografts confirmed our in-vitro results by marked reduction of tumor growth, which was paralleled by a reduction in Ki67 and CD31, as proliferative and angiogenic markers, respectively. Importantly, 2HF also reduced the level of vimentin and increased E-cadherin, reversing the phenotype of epithelial-to-mesenchymal transition. In summary, 2HF demonstrated strong anti-proliferative, anti-angiogenic and pro-differentiation effects on in-vitro and in-vivo lung cancer models, whilst sparing normal cells. This holds not only great promise for therapeutic use but also suggests a role for 2HF in the prevention of lung cancer (Supported by NIH grant CA 77495 and Beckman Research Institute of the City of Hope). Citation Format: Sharad S. Singhal, James Figarola, Jyotsana Singhal, Lokesh Nagaprashantha, Sanjay Awasthi. 2′-Hydroxyflavanone inhibits lung cancer growth by inhibiting tumor cell proliferation and angiogenesis. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 2816. doi:10.1158/1538-7445.AM2015-2816
An endoscopic pancreatic function test with cholecystokinin-octapeptide for the diagnosis of chronic pancreatitis
Authors: Darwin L Conwell, Gregory Zuccaro, John J Vargo, J Brad Morrow, Nancy Obuchowski, John A Dumot, Patricia A Trolli, Allison Burton, Cathy O'laughlin, Frederick Van Lente
Journal: Clinical Gastroenterology and Hepatology (2003)
Talking Trash: The Economic and Environmental Issues of Landfills
Authors: David Taylor
Journal: Environmental Health Perspectives (1999)

The U.S. per-capita figure for garbage production has topped four pounds per person per day, and that amount is rising at roughly 5% per year. In the past, municipal solid waste was sent to the nearest local landfill or incinerator. But in 1988, the U.S. Environmental Protection Agency instituted the first federal standards for landfills, designed to make them safer. Over 10,000 small municipal landfills have since been consolidated into an estimated 3,500 newer, safer landfills, some of which are "megafills" that can handle up to 10,000 tons of waste a day. The new landfills are outfitted to prevent air and water pollution and limit the spread of disease by scavengers. Although the new landfills provide better controls against air and water pollution as well as an alternate source of municipal income, they are not entirely problem-free. Some experts believe the new landfill technology has not been properly tested and will therefore not provide protection in the long run. Others feel that poorer, less well-informed communities are targeted as sites for new landfills. In addition, many people that live near megafills, which may draw garbarge from several states, are unhappy about the noise, truck traffic, odors, and pests caused by the facilities.
Pathology and laboratory medicine
Authors: J. Geradts
Journal: JAMA (1994)

Immunohistochemical (IHC) analysis of estrogen receptors (ERs) and progesterone receptors (PRs) is becoming an alternative to the biochemical ligand-binding assays currently used to study these receptors. Numerous studies have shown good correlation between the two methods. Moreover, it has been suggested that IHC ER/PR analysis may be better at predicting response to endocrine therapy.<sup>1,2</sup>In carcinomas of the ovary and endometrium, where the stromal elements may be rich in steroid receptors, only IHC receptor analysis can eliminate the effect of contamination because it localizes receptors to specific cell types. While IHC receptor assays work reliably on frozen tissue sections and cytological preparations,<sup>3</sup>they are less reliable on formalin-fixed, paraffin-embedded tissues, although significant improvements in the technique have been reported.<sup>1,2</sup>Recently, quantification of ER/PR content of tissue sections has been possible with image analysis (IA) systems.<sup>2</sup> Image analysis uses a computer to analyze digitized microscopic images. It