tbuckley/cabot-search huggingface dataset:
In This Issue
Journal: Journal of Clinical Investigation (2009)

Fetal metabolic development affected by mother's dietMaternal obesity is one factor thought to contribute to the rise in the number of children classified as obese and diagnosed with metabolic diseases such as type 2 diabetes and nonalcoholic fatty liver disease (NAFLD).However, McCurdy and colleagues have now found that the offspring of both lean and obese nonhuman primate mothers chronically consuming a high-fat diet (HFD) exhibited an increased risk of developing NAFLD compared with fetal offspring from mothers fed a control diet (323-335).When analyzed early in the third trimester, fetal offspring from both lean and obese HFD-fed mothers showed evidence of NAFLD, including increased levels of hepatic triglycerides.The increased levels of hepatic triglycerides persisted into the postnatal period and were accompanied by an increased percentage of body fat.Importantly, if HFD-fed mothers were reverted to a low-fat diet during a subsequent pregnancy, this fetal offspring exhibited lower, but not normal, hepatic triglyceride levels, even if the mother remained obese.The authors therefore suggest that a developing fetus is highly susceptible to maternal consumption of excess lipids whether or not the mother is obese and that a healthy maternal diet is important for the metabolic health of a developing fetus.
Effects of Pregnancy on Work Performance
Journal: JAMA (1984)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Total hip replacement in England
Authors: E. F. Rosenberg
Journal: JAMA (1970)

Involvement of the hips is an often-ocurring, and frequently disastrous complication of both rheumatoid and osteoarthritis. In these conditions early symptoms of hip joint difficulties are certain forerunners of serious deterioration. Involvement of one side often is followed by involvement of the other side and pain and disability tend to increase until walking and standing become impossible. Disabling arthritis of the hips may be encountered also as a late complication of other ailments, notably coxa plana, Legg's disease, slipped femoral epiphyses, aseptic necrosis of the femoral head, Charcot's disease of the hip, Paget's disease of the pelvic bones, fat embolism, and avascular necrosis of the femoral head subsequent to dislocation. Similarly, arthritis may develop in the hip following surgical treatment for fractures of the femoral head and neck. In some instances, the hip joint deteriorates without recognizable cause in persons with "dysplastic" or poorly formed pelvic bones. There is no
Phalangeal Metastases From Bronchogenic Carcinoma
Authors: Irving Karten
Journal: JAMA (1978)

<h3>To the Editor.—</h3> The recent report "Phalangeal Metastases From Bronchogenic Carcinoma" (239:226, 1978) verifies the uncommon occurrence of metastatic implants in digits giving the appearance of osteomyelitis or gout. The authors emphasize the presentation of their cases with involvement of a single toe or finger, but actually bone scans and roentgenograms showed polyarticular disease. We reported a similar case (179:162, 1962) in which five fingers showed metastases from bronchogenic carcinoma. Our initial diagnosis was rheumatoid arthritis because of the symmetrical fusiform swellings present in our patient. The physician, therefore, should be alert to the fact that swellings in three or more digits resembling rheumatoid arthritis, and not just monarticular disease, may occasionally be from metastases from carcinoma of the lung.
Correspondence
Authors: Frank Detterbeck, Lynn Tanoue, Amanda Reid
Journal: Journal of the National Comprehensive Cancer Network (2013)

the development of standardized screening practices (eg, protocols for imaging acquisition, reporting of results); processes for careful selection of candidates; creation of registries for continuous data collection and reassessment of outcomes in real practices, including false-positive rates, costs, and patient-reported outcomes. 4 By promoting standardized practices and continuously monitoring outcomes, health care institutions will ensure that patients realize the benefits of screening while avoiding unnecessary escalation in costs.
Endoscopic management of gastrointestinal motility disorders – part 1: European Society of Gastrointestinal Endoscopy (ESGE) Guideline
Authors: Bas L. A. M. Weusten, Maximilien Barret, Albert J. Bredenoord, Pietro Familiari, Jan-Michel Gonzalez, Jeanin E. van Hooft, Sauid Ishaq, Vicente Lorenzo-Zúñiga, Hubert Louis, Suzanne van Meer, Helmut Neumann, Daniel Pohl, Frederic Prat, Daniel von Renteln, Edoardo Savarino, Rami Sweis, Jan Tack, Radu Tutuian, Jan Martinek
Journal: Endoscopy (2020)

Main Recommendations ESGE recommends the use of a graded pneumatic dilation protocol in achalasia, starting with a 30-mm dilation and followed by a 35-mm dilation at a planned interval of 2 – 4 weeks, with a subsequent 40-mm dilation when there is insufficient relief, over both a single balloon dilation procedure or the use of a larger balloon from the outset. Strong recommendation, high quality of evidence, level of agreement 100 %. ESGE recommends being cautious in treating spastic motility disorders other than achalasia with peroral endoscopic myotomy (POEM). Strong recommendation, very low quality of evidence, level of agreement 87.5 %. ESGE recommends against the routine use of botulinum toxin injections to treat patients with non-achalasia hypercontractile esophageal motility disorders (Jackhammer esophagus, distal esophageal spasm). However, if, in individual patients, endoscopic injection of botulinum toxin is chosen, ESGE recommends performing injections into four quadrants of the lower esophageal sphincter and in the lower third of the esophagus. Strong recommendation, low quality of evidence, level of agreement 78.6 %. ESGE recommends that endoscopic pylorus-directed therapy should be considered only in patients with symptoms suggestive of gastroparesis in combination with objective proof of delayed gastric emptying using a validated test, and only when medical therapy has failed. Strong recommendation, very low quality of evidence, level of agreement 100 %. ESGE recommends against the use of botulinum toxin injection in the treatment of unselected patients with gastroparesis. Strong recommendation, high quality of evidence, level of agreement 92.9 %. ESGE recommends consideration of gastric peroral endoscopic myotomy (G-POEM) in carefully selected patients only, because it is an emerging procedure with limited data on effectiveness, safety, and durability. G-POEM should be performed in expert centers only, preferably in the context of a clinical trial. Strong recommendation, low quality of evidence, level of agreement 100 %.
Index-Catalogue of the Library of the Surgeon-General's Office
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Figure Legend
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Year in Review
Authors: Melina R. Kibbe
Journal: JAMA Surgery (2016)

Now that a year has passed since assuming the position of Editor of JAMA Surgery, I would like to convey some of our accomplishments to the readers, authors, and peer reviewers of the journal.First, one of our main missions this past year was to reduce the time from acceptance to online publication.We have succeeded with our goal, as the time from acceptance to online publication is now approximately 2 months, the lowest it has been in many years.We have accomplished this while maintaining a low peer reviewer turnaround time of only 10 days.Our overall manuscript acceptance rate for 2015 was 25.8%, with an acceptance rate of 10.2% for original submissions and 29% for research letters (Table ).I am also pleased to report that the overall number of submissions has increased by 18.7% from 2014 to 2015, a continuing trend.Another accomplishment is our extended reach through social media.Amalia Cochran, MD, Web and Social Media Editor, has led the charge to increase the journal's presence on Twitter and Facebook.JAMA Surgery currently has more than 12 000 Twitter followers, which is more than any of the other general surgery journals, and the journal has close to 4000 Facebook likes.Combined with the visits to the journal's website, recipients of weekly electronic tables of contents, and our print distribution, the reach of JAMA Surgery is very large.The creation of the new article types has been a success.Under the leadership of Gerard Doherty, MD, Review Editor, JAMA Surgery now publishes an evidence-based review on common topics of interest to our readers each month.Under the leadership of Justin Dimick, MD, Surgical Innovation Editor, the journal has been publishing one Surgical Innovation article each month.JAMA Surgery also expanded the CME and MOC we offer our readers during 2015.We now offer 3 credit hours of CME each month that all count for MOC.Most importantly, I would like to thank the readers, authors, peer reviewers, and editorial board members for contributing to the journal.Through your support, we aim to ful-fill our mission "to promote the art and science of surgery by publishing relevant peer-reviewed research to help surgeons optimize patient care" and serve "as a forum for discussion of issues pertinent to surgery, such as the education and training of the surgical workforce, quality improvement, and the ethics and economics of healthcare delivery.
The Nutrition of the Infant.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
National Medical Association centennial
Authors: C. Marwick
Journal: JAMA (1995)

A CENTURY AGO, 12 African-American physicians, barred from joining local and national medical organizations and unable to obtain hospital privileges for treating their patients, gathered to form what became the National Medical Association (NMA). This year, African-American physicians for the first time head a half dozen of the most prestigious medical organizations in the United States. For its 100th annual meeting, the NMA went back to Atlanta, Ga, where it began. On a hot Sunday morning in July, several hundred members walked the three blocks from the headquarters hotel to the First Congregational Church at the corner of Courtland Street and John W. Dobbs Drive in downtown Atlanta to celebrate their organization's founding in the church in 1895. Segregation was the law of the land at the time, reaffirmed by a Supreme Court decision,<i>Plessy vs Ferguson</i>, the following year. "Conceived in no spirit of racial exclusiveness, fostering no ethnic
Neuropsychologic Impact of Standard-Dose Systemic Chemotherapy in Long-Term Survivors of Breast Cancer and Lymphoma
Authors: Tim A. Ahles, Andrew J. Saykin, Charlotte T. Furstenberg, Bernard Cole, Leila A. Mott, Karen Skalla, Marie B. Whedon, Sarah Bivens, Tara Mitchell, E. Robert Greenberg, Peter M. Silberfarb
Journal: Journal of Clinical Oncology (2002)

PURPOSE: The primary purpose of this study was to compare the neuropsychologic functioning of long-term survivors of breast cancer and lymphoma who had been treated with standard-dose systemic chemotherapy or local therapy only. PATIENTS AND METHODS: Long-term survivors (5 years postdiagnosis, not presently receiving cancer treatment, and disease-free) of breast cancer or lymphoma who had been treated with systemic chemotherapy (breast cancer: n = 35, age, 59.1 ± 10.7 years; lymphoma: n = 36, age, 55.9 ± 12.1 years) or local therapy only (breast cancer: n = 35, age, 60.6 ± 10.5 years; lymphoma: n = 22, age, 48.7 ± 11.7 years) completed a battery of neuropsychologic and psychologic tests (Center for Epidemiological Study–Depression, Spielberger State-Trait Anxiety Inventory, and Fatigue Symptom Inventory). RESULTS: Multivariate analysis of variance, controlling for age and education, revealed that survivors who had been treated with systemic chemotherapy scored significantly lower on the battery of neuropsychologic tests compared with those treated with local therapy only (P &lt; .04), particularly in the domains of verbal memory (P &lt; .01) and psychomotor functioning (P &lt; .03). Survivors treated with systemic chemotherapy were also more likely to score in the lower quartile on the Neuropsychological Performance Index (39% v 14%, P &lt; .01) and to self-report greater problems with working memory on the Squire Memory Self-Rating Questionnaire (P &lt; .02). CONCLUSION: Data from this study support the hypothesis that systemic chemotherapy can have a negative impact on cognitive functioning as measured by standardized neuropsychologic tests and self-report of memory changes. However, analysis of the Neuropsychological Performance Index suggests that only a subgroup of survivors may experience long-term cognitive deficits associated with systemic chemotherapy.
Mediastinoscopy
Authors: J. K. Ross, J. R. Mikhail, R. A. B. Drury, R. D. Levis, D. N. Mitchell
Journal: Thorax (1970)

The surgical and anaesthetic technique used in mediastinoscopy during the investigation of 124 patients is described. A histological diagnosis was made in 109 cases (88%). Of the 22 cases other than sarcoidosis a positive diagnosis was obtained in all. In 102 cases with suspected sarcoidosis, the histological appearances of the nodes were compatible with sarcoid in 86 (84%). No serious complications were encountered. It is concluded that this procedure should be carried out by an experienced thoracic surgeon and will yield better diagnostic tissue than other comparable procedures.
Identification of TRP-2 as a Human Tumor Antigen Recognized by Cytotoxic T Lymphocytes
Authors: Rong-Fu Wang, Ettore Appella, Yutaka Kawakami, Xiaoqiang Kang, Steven A. Rosenberg
Journal: The Journal of Experimental Medicine (1996)

The infusion of TIL586 along with interleukin-2 into the autologous patient with metastatic melanoma resulted in the objective regression of tumor. A gene encoding a tumor antigen recognized by TIL586 was previously isolated and shown to encode gp75 or TRP-1. Here we report that TRP-2 was identified as a second tumor antigen recognized by a HLA-A31-restricted CTL clone derived from the TIL586 cell line. The peptide LLPGGRPYR epitope was subsequently identified from the coding region of TRP-2 based on studies of the recognition of truncated TRP-2 cDNAs and the HLA-A31 binding motif. This epitope peptide was capable of sensitizing target cells for lysis by a CTL clone at 1 nM peptide concentration. Although some modified peptides could be recognized by the CTL clone, none were found to be better recognized by T cells than the parental peptide. Like other melamona differentiation antigens, TRP-2 was only expressed in melanoma, melanocytes, and retina, but not in other human tissues tested.
Calcium Requirements
Authors: B. E. C. Nordin
Journal: BMJ (1963)

We have as yet no ideal screening tonometer, but the Schiotz instrument or a modern version of the Berens- Tolman ocular hypertension indicator would suffice until in the fullness of time we can mass-produce electronic tonometers at reasonable cost.D. S. Lees in Health Through Choice"2 writes: " The fundamental point is that medical care should be open to experiment and innovation.At present it is closed."As the Supplementary Ophthalmic Service has been static and closed for 141 years, would the Minister of Health consider opening the south-east corner of the Welfare State as a trial ground for experiment and innovation ?-I am, etc.,
A Primer for Diabetic Patients: A Brief Outline of the Treatment of Diabetes with Diet and Insulin, Including Directions and Charts for the Use of Physicians in Planning Diet Prescriptions
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Health Effects during a Smog Episode in West Germany in 1985
Authors: H. E. Wichmann, W. Mueller, P. Allhoff, M. Beckmann, N. Bocter, M. J. Csicsaky, M. Jung, B. Molik, G. Schoeneberg
Journal: Environmental Health Perspectives (1989)

In January 1985 a smog period occurred for 5 days in parts of West Germany, including the Rhur District. Mortality (24,000 death certificates), morbidity in hospitals (13,000 hospital admissions, 5400 outpatients, 1500 ambulance transports) and consultations in doctors' offices (1,250,000 contacts) were studied for a 6-week period including the smog episode and a time interval before and thereafter. The study region was the State of North Rhine-Westfalia (16 million inhabitants), but the analysis is restricted to the comparison of the polluted area and a control area (6 million inhabitants each). During the smog period, mortality and morbidity in hospitals increased in the polluted area, but there was no substantial increase in the control area. The increases were for the total number of deaths 8 vs. 2% (polluted area vs. control area), for hospital admissions 15 vs. 3%, for outpatients 12 vs. 5% and for deliveries by ambulance to hospitals 28% in the polluted area (not investigated in the control area). The effects were more pronounced for cardiovascular diseases than for respiratory diseases. The consultations in doctors' offices show a slight decrease (-2 vs. -4%). Regression analysis shows a moderate influence of temperature, but a strong influence of ambient air pollution. The maxima of the ambient concentrations are more important on the same day, whereas the influence of the daily averages is more pronounced after a delay of 2 days. The results are discussed considering other possible confounders such as indoor pollution and psychogenic influences of the alarm situation. In total, the study suggests moderate health effects due to increased air pollution during the smog episode.