tbuckley/cabot-search huggingface dataset:
Seniors needn't go `all out' for fitness
Journal: JAMA (1981)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Childhood Gastroesophageal Reflux
Authors: Patrick F. Bray
Journal: JAMA (1977)

Thirteen infants and children with proved gastroesophageal (GE) reflux had complaints that suggested a CNS disorder. Symptoms began in early infancy in ten cases, but accurate diagnosis and proper treatment were not instituted in three cases until three to five years of age. A CNS basis for their disease was suspected because they exhibited specific signs or because the importance of associated gastrointestinal (GI) and respiratory tract symptoms was not appreciated. The presenting CNS symptoms and signs included dystonia in 11, developmental retardation in ten, dysphagia in nine, seizures in six, and extreme irritability in ten. We believe that the diagnosis of symptom-causing GE reflux is being missed regularly. The effects of proper medical or surgical therapy are often dramatic, and the consequences of missed diagnosis or improper treatment are potentially lethal. (<i>JAMA</i>237:1342-1345, 1977)
A Lecture on the Relation of Madness to Crime
Authors: J. C. Bucknill
Journal: BMJ (1884)

±i*rH MAXR3A J2A b 3 -Then, ist,o tese tatemenets that the wards wetb& i6t all lighted at night, asid that tiere w.s ot. an diderlyin each ward;*l`thInk if pou compare 'he numriber df rooms in thie a ce tth the gniumber of lan- teirnS provided for the field-hospitals, you will se X was hiotpos §ible to' light them all.But there were lights w6he'tley were most needed, viz., in the hall, staircase, and; corridors andw' e.rver they were required for special cases.In short, all that we. had were in use * and as regar4s the complaint that there was not in orderly in each ward at night, the answer is that the whole 'of -the orirlies at my disposal would n'ot have suffic6d for such a purpose; moreover, that it w,as un- necessiry.-Nomedical officer, I imagiiie, will contend that our present hospital- 'system. is a perfect one.E reality, it is still 'in the inceptive stage.It. is comparatively.a thing -of yesterday, and its development, even when it has not been' actively opposed, has at least been regarded with some disfavour, Whereas the regimental system was the product of the combined efforts of several generations of-military as wellas of medi- 'cal officers.Nlor do we' contend that our work in Egypt was faultless.Human endeavotrs, indeed, rarely meet with absolute success, but it may be -fairly questioned whether any other part 'of our military organisation would have sustained more successfully than the medical service has done the attacks of hostile and unscrupulous critics, and such an' investigation as was made by Lord Morley's committee.Opinions may differ regarding the prowess of the army against 'which our troops hadto-fight in Egypt in 1882, but there is no room for doubt as-to the strength of the eniemy against which the medical service had to contend.When itisconsideredthattherewere l, 187casesof fever treated in the military hospitals during that campaign with only 33 deaths, a mortality of 2.77 per eent.; that there were 171 cases of sdinstroke with only three' deaths; that, with 1,139 cases of ophthalmia, not a man lost his sight; that there were 2,725 cases of dysentery, diarrhcea, hepatitis, and other diseases of the digestive system, with only 31 deaths, or 1. 13 per cent..; aznd that with 691 cases of injury, including those sustained in action, no man lost his life from pyremia, erysipelas, or hospital-gangrene, results tinprecedented in the history of this or any other nation, and attributable to the exertions of medical officers imbued with the doctrines of Lister, and faithful to the teachings of Parkes and the present distinguished profesaors of the Army Medical School, we may be sure that justice will, sooner or later, be rendered to those who obtained so signal a victory over so dangerous a foe.
Hyposensitisation.
Authors: J O Warner, J W Kerr
Journal: BMJ (1987)

HyposensitisationHyposensitisation for allergic disease was introduced at St Mary's Hospital, London, 75 years ago and continued largely as a treatment given by general practitioners until the Committee on the Safety of Medicines (CSM) last year effectively stopped this treatment in general practice.'The original workers, Noon and Freeman, observed 20 hay fever sufferers who had been treated with injections ofboiled grass pollen extracts.23Their study was based on the false premise that pollen produced a toxin that caused the disease and that injections would induce antitoxin production.The report of "a distinct amelioration of symptoms" was enthusiastically received by doctors and patients desperate for any treatment ofallergic diseases.With few exceptions the ensuing pharmaceutical investment in this treatment was not accompanied by good scientific assessment of efficacy.More recently the introduction of safe and effective drugs has pre-empted immunotherapy as a first line treatment for most allergic disorders.Furthermore, occasional severe adverse reactions and a few deaths led inevitably to the CSM action.Un- doubtedly a critical review of immunotherapy was long overdue, but the recommendations have had important consequences for some allergic patients.The CSM document treated hyposensitisation as a single treatment and did not look at the needs of specific patients with different allergic conditions, such as allergic rhinitis, extrinsic asthma, or insect venom hypersensitivity.Never- theless, there is good evidence from double blind placebo controlled trials which shows that hyposensitisation works in bee and wasp venom hypersensitivity,4 rag weed hayfever (not a problem in Britain),' and perhaps rhinitis induced by grass pollen.6Insect sting hypersensitivity is potentially fatal, and hyposensitisation is undoubtedly effective, although problems remain with this treatment.7Most patients with seasonal allergic symptoms are well controlled with the newer histamine 1 antagonists sometimes combined with topical corticosteroids.Using immunotherapy when oral and topical treatment produce little benefit is controversial, though sometimes worth while.'Apart from vaccines con- taining extracts of grass pollen, house dust mite, and insect venoms, there is little evidence that other preparations work in allergic disorders.These include antibiotics, for which the CSM Update stated that there is "convincing evidence of efficacy."There is no antibiotic vaccine available for hypo- sensitisation, which the CSM appears to have confused with "rush desensitization."Hyposensitisation for asthma requires special considera-
Highlights from Recent Cancer Literature
Journal: Cancer Research (2010)

Mutations in BRCA1 or BRCA2 that lead to defective homologous recombination (HR) are associated with familial breast and ovarian cancer.Issaeva and colleagues screened novel drugs for compounds that selectively killed BRCA2defective cells and identified 6-thioguanine (6GT), which induces DNA double-strand breaks (DSB) that are repaired by HR.Moreover, the authors revealed that 6GT is as effective as a poly(ADP-ribose) polymerase (PARP) inhibitor in selectively killing BRCA2-defective tumor cells in vivo and efficiently kills BRCA1-defective tumor cells that have acquired PARP inhibitor resistance through genetic reversion of the BRCA2 gene.These data indicate that HR is involved in repair of 6GT-induced DSBs as well as mismatch repair-independent 6GT-defective tumors and highlight a potential role for 6GT in treatment of advanced PARP inhibitor-resistant tumors.
Erlotinib Warning
Authors: Bridget M. Kuehn
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Implications of Regional Differences in Spending
Authors: George L. Weber
Journal: Annals of Internal Medicine (2004)

Letters20 January 2004Implications of Regional Differences in SpendingGeorge L. Weber, DOGeorge L. Weber, DOFrom Philadelphia, PA 19115.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-140-2-200401200-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Fisher and colleagues suggest that patients help themselves by seeking out evidence of alternative treatments and asking their provider of care if it might make sense to “watch and wait” before intervening (1, 2). I believe the authors should see a few patients in Philadelphia to get a real reality check. The government first needs to fix the liability crisis. Then, it needs to address reimbursement issues so that a primary care physician doesn't have to work more hours than would be allowed for an airline pilot or a truck driver to make a decent living. When ...References1. Fisher ES, Wennberg DE, Stukel TA, Gottlieb DJ, Lucas FL, Pinder EL. The implications of regional variations in Medicare spending. Part 1: the content, quality, and accessibility of care. Ann Intern Med. 2003;138:273-87. [PMID: 12585825] LinkGoogle Scholar2. Fisher ES, Wennberg DE, Stukel TA, Gottlieb DJ, Lucas FL, Pinder EL. The implications of regional variations in Medicare spending. Part 2: health outcomes and satisfaction with care. Ann Intern Med. 2003;138:288-98. [PMID: 12585826] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Philadelphia, PA 19115. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe Implications of Regional Variations in Medicare Spending. Part 1: The Content, Quality, and Accessibility of Care Elliott S. Fisher , David E. Wennberg , Thrse A. Stukel , Daniel J. Gottlieb , F. L. Lucas , and Étoile L. Pinder The Implications of Regional Variations in Medicare Spending. Part 2: Health Outcomes and Satisfaction with Care Elliott S. Fisher , David E. Wennberg , Thrse A. Stukel , Daniel J. Gottlieb , F. L. Lucas , and Étoile L. Pinder Implications of Regional Differences in Spending Hyman Gaylis Implications of Regional Differences in Spending Franklin Gaylis Implications of Regional Differences in Spending Elliott S. Fisher , Dan Gottlieb , and David Wennberg Implications of Regional Differences in Spending Rudolph J. Mueller Implications of Regional Differences in Spending Barry Kisloff Implications of Regional Differences in Spending Howard A. Levin Implications of Regional Differences in Spending Rudy Fernandes Metrics 20 January 2004Volume 140, Issue 2Page: 147KeywordsPrimary care physicians ePublished: 20 January 2004 Issue Published: 20 January 2004 Copyright & PermissionsCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Abstract LB-273: Comprehensive sequencing analyses of uterine and ovarian carcinosarcoma
Authors: Seiichi Mori, Osamu Gotoh, Yuko Sugiyama, Kazuyoshi Kato, Tetsuo Noda
Journal: Cancer Research (2017)

Abstract Carcinosarcoma (CS) of the uterus or the ovary, known as malignant mixed Muellerian tumor, is a biphasic neoplasm composed of malignant epithelial (carcinoma) and mesenchymal (sarcoma) elements. CS is a rare disease (two per 100,000 women) and exhibits poor prognosis (5-year survival rates: uterus and ovary; 31 and 7.5 %, respectively). Treatment regimen for CS follows to that for endometrioid adenocarcinoma (EC) since CS has been considered as an aggressive form of high-grade EC. However, CS has a significantly worse prognosis than EC. Identification of a molecular target and/or a molecular mechanism in tumorigenesis from a large cohort study may improve unfavorable outcomes. Toward this aim, we perform targeted resequencing analysis with a panel of 596 genes, which were previously implicated as critical not only for uterine, ovarian or sarcomatus oncogenesis but also for molecular targets in therapeutics. Through analyses of 109 cases of uterine and ovarian CS, consensus clustering with deregulated pattern of CS genome identified four genomic subtypes that correlate with genetic or epigenetic alterations, histopathology and patient outcomes. Moreover, potentially actionable alterations were found in a substantial number of genes (including PIK3CA, MTOR, KRAS and CCNE1). This study would provide deep insights into the development of novel diagnostic and personalized treatment for CS patients. Citation Format: Seiichi Mori, Osamu Gotoh, Yuko Sugiyama, Kazuyoshi Kato, Tetsuo Noda. Comprehensive sequencing analyses of uterine and ovarian carcinosarcoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr LB-273. doi:10.1158/1538-7445.AM2017-LB-273
Applied Microbiology, Baltimore
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Postgraduate Medical Journal, London
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Practice
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Incorrect Wording
Authors: Kim Thorburn
Journal: JAMA (1999)

an injury was intentional (assault and/or self-inflicted) or unintentional.Injury-related deaths were not recorded.Comment.A majority of prison systems performed prisoner injury monitoring.However, monitoring was usually an administrative function, rather than a health services function.The collection of injury data from incident reports and focus on the activities leading to injuries were indicative of the administrative concern about violence.Application of public health surveillance methods to prisoner injury could contribute useful data for the development of violence (and other injury) risk reduction and prevention programs.
Incidence of leukemia following treatment of hyperthyroidism. Preliminary report of the Cooperative Thyrotoxicosis Therapy Follow-Up Study
Authors: E. L. Saenger
Journal: JAMA (1968)

This study was conducted to test for an increase in the incidence of leukemia in hyperthyroid patients treated by radioactive iodine<sup>131</sup>I as compared to the incidence in patients treated differently. Of 36,000 patients from 26 medical centers, approximately 22,000 were treated with<sup>131</sup>I and about 14,000 were treated surgically or solely with antithyroid drugs. More than 96% of patients were followed up. Forty-four cases of leukemia occurred after, and 16 before, treatment. The incidence of leukemia in patients treated with<sup>131</sup>I for hyperthyroidism and the incidence in those treated surgically do not differ. Patients both undergoing surgery and receiving<sup>131</sup>I have a higher incidence of leukemia than any other treatment group. The observed mortality from leukemia for hyperthyroid patients is 50% higher than that of the US population.
Abstract 3706: The CRISPR-Cas9 minipig: A transgenic toolbox pig to produce specific genome editing in designated tissues
Authors: Martin F. Berthelsen, Maria Riedel, Mikkel H. Vendelbo, Aage K. Alstrup, Frederik Dagnæs-Hansen, Yonglun Luo, Simone S. Møller, Henrik Callesen, Jannik E. Jakobsen, Martin K. Thomsen
Journal: Cancer Research (2019)

Abstract The aim of the project is to generate a toolbox pig model. This is being done because the pig probably is the best non-primate model in translational medicine. Unfortunately, pig models have proven difficult to produce. The two main complications have been the cloning of viable pigs and that just a few genes are altered, which often is not sufficient to induce the desired disease. Especially, models based on multiple genetic modifications of the pig genome, e.g. cancer, are challenging to generate. This was changed with the development of the CRISPR-Cas9 technology, which made it possible to perform multiple in vivo gene editing. We have cloned an inducible Cas9 expressing minipig and have obtained healthy F1 offspring. Activation of the Cas9 expression is attained by transduction with adeno-associated virus that delivers both the recombinase and the guide RNA to the designated tissue. This design provides spatial and temporal control of the activation. The Cas9 expression is mediated by a ubiquitous promotor, which also co-expresses fluorescent proteins for expression analysis. Transgenic Cas9 expression is observed in all major organs with strong expression in the epithelia, muscles and hepatocytes. Successful in vitro gene editing has been conducted in primary keratinocytes and fibroblast obtained from the transgenic pigs, which confirms the genetic design. By delivery of our construct by adeno-associated virus to the skin of the pigs, In vivo activation of the transgenic construct has been achieved. To validate the model, lung cancer has been induced in nine pigs by alteration a panel of cancer related genes including STK11, TP53, PTEN, and KRAS, all key drivers of human lung cancer. To obtain the constitutive active KRAS-G12D isoform of the KRAS oncogene a repair template was supplied. The pigs are being followed by PET/CT scanning in combination with 18F-FDG as a tracer. Preliminary data indicates abnormalities/cancer initiation in the pigs eight months after induction. In conclusion, an inducible Cas9 expressing minipig allows rapid gene editing to study different scenarios of human cancer in a pig model. The development of the Cas9 pig will extend the variety of pig disease models, both to generate a model of lung cancer as proposed but also models for other cancers. Citation Format: Martin F. Berthelsen, Maria Riedel, Mikkel H. Vendelbo, Aage K. Alstrup, Frederik Dagnæs-Hansen, Yonglun Luo, Simone S. Møller, Henrik Callesen, Jannik E. Jakobsen, Martin K. Thomsen. The CRISPR-Cas9 minipig: A transgenic toolbox pig to produce specific genome editing in designated tissues [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3706.