tbuckley/cabot-search huggingface dataset:
Authors' response
Authors: Thomas R de Wijkerslooth, Esther M Stoop, Patrick M Bossuyt, Monique E van Leerdam, Paul Fockens, Ernst J Kuipers, E Dekker
Journal: Gut (2012)

The implementation of molecular profiling technologies in oncology deepens our knowledge for the molecular landscapes of cancer diagnoses, identifying aberrations that could be linked with specific therapeutic vulnerabilities. In particular, there is an increasing list of molecularly targeted anticancer agents undergoing clinical development that aim to block specific molecular aberrations. This leads to a paradigm shift, with an increasing list of specific aberrations dictating the treatment of patients with cancer. This paradigm shift impacts the field of clinical trials, since the classical approach of having clinico-pathological disease characteristics dictating the patients9 enrolment in oncology trials shifts towards the implementation of molecular profiling as pre-screening step. In order to facilitate the successful clinical development of these new anticancer drugs within specific molecular niches of cancer diagnoses, there have been developed new, innovative trial designs that could be classified as follows: i) longitudinal cohort studies that implement (or not) "nested" downstream trials, 2) studies that assess the clinical utility of molecular profiling, 3) "master" protocol trials, iv) "basket" trials, v) trials following an adaptive design. In the present article, we review these innovative study designs, providing representative examples from each category and we discuss the challenges that still need to be addressed in this era of new generation oncology trials implementing molecular profiling. Emphasis is put on the field of breast cancer clinical trials.
The International Medical Annual and Practitioner's Index: A Work of Reference for Medical Practitioners.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Future Etiologic Research in Occupational Cancer
Authors: Jack Siemiatycki
Journal: Environmental Health Perspectives (1995)

Research focused on occupational exposure has been one of the cornerstones of epidemiological research into the etiology of cancer.It is appropriate to critically assess the contribution of this research effort and to assess the potential for making significant progress in the future in unraveling the etiology of cancer by studying the occupational environment.The study of the occupational environment has indeed been very fruitful.It is likely that there remain many more carcinogens to be discovered, but we have not deployed adequately sensitive study methods.The two major obstacles to quality research have been inadequate exposure assessment and insufficient sample sizes.Quality exposure assessment requires the participation of trained experts (industrial hygienists, chemists, etc.); it also requires an adequate information base on the exposures that occur in different workplaces.We need structures and career paths that facilitate the participation of exposure experts in epidemiological research.We need active large-scale industrial hygiene surveys to better characterize the U.S. workplace.This will be useful for epidemiological studies and for public health purposes.Community-based case-control studies will need to be much larger than they have been traditionally, with 1000 as a minimum number of cases and controls.
December 12, 2001
Journal: JAMA (2001)

Glenn M. Chertow, MD, MPH; Joshua Lee, MD; Gilad J. Kuperman, MD; Elisabeth Burdick; Jan Horsky; Diane L. Seger; Rita Lee; Aparna Mekala; Jean Song; Anthony L. Komaroff, MD; David W. Bates, MD, MSc
TWO CASES OF HEMORRHAGE FOLLOWING PERITONSILLAR ABSCESS
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Erythropoietin alterations in patients with uremia, renal allografts, or without kidneys
Authors: E. A. Mirand
Journal: JAMA (1969)

Alterations in the levels of erythropoietin (erythropoietic stimulating factor [ESF] were measured in 43 patients with a variety of renal diseases including chronic pyelonephritis, chronic glomerulonephritis, and nephrosclerosis. In 20 patients well-maintained on a regimen of long-term hemodialysis, ESF activity was detectable and, at times, increased, both in plasma and urine specimens. Thirteen anephric patients were observed for postoperative periods of 1 to 116 days. Elevated ESF activity was present in 22 (29%) of 75 samples assayed, and ESF activity increased over time. Extrarenal ESF is present to a significant degree in anephric man, and is not necessarily directly relatable to the peripheral-blood hematocrit reading or degree of bone-marrow activity. Erythropoietin levels were measured in 57 specimens from 12 patients with cadaver renal allografts at periods up to 232 days postoperatively. Elevations of ESF levels can accurately reflect chronic renal-graft rejection,
THE BEGINNING OF ARTERIOSCLEROSIS.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Leads from the MMWR. Risks associated with human parvovirus B19 infection
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Early appearance of breast cancer (BC) and its patterns of expression for HER-2/NEU and hormonal receptors (HR)
Authors: R. Villalobos, F. Bustamante, A. Castruita, A. Silva, M. Perez, G. Olivares, M. Silva
Journal: Journal of Clinical Oncology (2004)

9728 Background: To evaluate the age of presentation of breast cancer (BC) and its correlation with the expression of HER-2/NEU and hormonal receptors in Mexican women Methods: A descriptive analysis of 101 patients with breast cancer was carried out in the Oncology Hospital 'Siglo XXI' during the year 2002–2003.Testing of herceptes and determination of hormonal receptors were correlated with the clinical stage and the patient age. Results: The average patient age was 52 years (range 29–86), the most frequent clinical stage was stage III (58.41%). 26 patients with HER-2/neu positive, 75 patients HER-2/neu negative. 37 patients with RE positive, 62 RE negative, 37 patients with RP positive and 61 with RP negative. A description of the subgroups is detailed in the table below. Undeterminable = 2, non classification = 5 When correlating HER-2/neu with hormonal receptors the following results were established: HER-2/neu positive is associated with RE negative (80.76%) and with RE positive (15.38%); HER-2/neu negative is associated with RP negative (84.61%), and with RP positive (7.69%), with RE negative (54.60%), and with RE positive (44.00%). Conclusions: The age of presentation of breast cancer is at least 10 years earlier than in developed countries, the over-expression of HER-2/neu is similar to that reported in the literature, and in the same way the appearance of positive hormonal receptors is associated with under-expression of HER-2/neu. The RE and RP are expressed in equal percentage in patients with HER-2/neu negative. Environmental and inherent factors need studying in order to investigate the early appearance of breast cancer. No significant financial relationships to disclose.
Implantation of tissue into the brain. An immunologic perspective
Authors: T. J. Gill
Journal: JAMA (1989)

The transplantation of neural tissue into the brain has the potential to repair the effects of trauma and of congenital abnormalities and to replace tissue that has ceased to function as the result of disease. The brain is not an immunologically privileged site in the strict sense; under certain carefully defined circumstances, grafts can last for long periods of time, but many such grafts are rejected naturally or following various types of provocation. Factors important to the survival of neural grafts are the use of embryonic tissue, the immunogenetic match, the level of expression of major histocompatibility complex antigens in brain cells close to the graft, and the presence of neural degeneration near the graft. Much additional basic experimental work must be done, however, before a rational approach to the clinical use of neural grafts can be undertaken. (<i>JAMA</i>. 1989;261:2674-2676)
Palm Readings
Authors: Lance Frazer
Journal: Environmental Health Perspectives (1998)

Scientists are taking technology in common laboratory usage for more than 15 years and adapting it in ways that may, quite literally, bring the laboratory into the field. The technology is known as surface plasmon resonance (SPR), and a team of scientists has taken a sensing unit that was once the size of an old-fashioned console television and shrunken it down into a handheld unit no bigger than a conductor's baton.
SUMMARIOS IN INTERLINGUA
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Synopsis of Gynaecology.
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Incorrect Key in Figure
Journal: JAMA Surgery (2013)

Charlotte L. Kvasnovsky, MD, MPH; Susan B. Kesmodel, MD; Josephine L. Gragasin, CTR; Valsamma Punnoose, MSN; Pamela A. Johnson, MHA; Rakhi Goel, MD; Srinevas K. Reddy, MD; Richard N. Pierson, MD; Ajay Jain, MD
TMJD Study
Authors: Tracy Hampton
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Interstate Reciprocity.
Authors: George W. Webster
Journal: JAMA (1906)

Chicago, Feb. 24, 1906. <h3>To the Editor:</h3> —In reply to the criticisms of my article on "Interstate Reciprocity," by Dr. B. D. Harison, secretary of the Michigan State Board of Registration in Medicine, I beg leave to submit the following: I desire at the outset to state that my article incorporated an educational plan which I proposed as a feasible working scheme and for which neither the Illinois State Board of Health nor the Council on Medical Education of the American Medical Association, with which I have the honor to be connected, are to be held responsible, as the article represents simply my own personal views. I desire to thank Dr. Harison for calling attention to the words "medical boards" in the sixth paragraph and for the substitution of the word "societies" therefor. I regret very much that Dr. Harison seems to have utterly failed to grasp the fundamental ideas
Respiratory Medicine
Authors: Irwin J. Polk
Journal: JAMA (1982)

Respiratory medicine is a large topic to cover in about 250 pocket-sized pages, especially when the product is a distillate of years of training and experience. Despite the difficulty, by selecting sensibly the areas of emphasis, writing concisely, and supplementing cleverly with pictures and diagrams, the author has produced a masterful summary of a complicated area of medical knowledge. The earlier chapters deal with anatomy and physiology, respiratory defense mechanisms, gas exchange and acid base balance, respiratory muscles, and control of breathing. This lays the groundwork for what is to come, a complete although abbreviated description of lung diseases such as pneumonia, asthma, bronchitis and emphysema and their consequences, respiratory failure, bronchiectasis, and abscesses. Particular diseases such as tuberculosis, sarcoidosis, tumors, and vascular diseases, and adverse effects of drugs are all covered. Each area is described with an introductory paragraph or two, followed by a discussion of epidemiology, pathology, clinical
THE WAYS OF THE ANTIVACCINATIONISTS.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
History of Psychiatry
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction: Sprout-Associated Infections
Journal: Annals of Internal Medicine (2001)

Corrections2 October 2001Correction: Sprout-Associated InfectionsFREESearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-135-7-200110020-00021 SectionsAboutVisual AbstractPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail In a recent article on sprout-associated infections (1), the last two sentences of the second paragraph in the Discussion section should be: “For sprout grower B, we found the outbreak strain of S. Senftenberg in animal feed from Oregon and Washington, supporting our hypothesis that the source of contamination for outbreak 3 was clover seed from Oregon. Finally, for sprout grower C, two outbreak-associated strains of Salmonella (S. Havana and S. Cubana) were found in seed lots used by this sprout grower.”Reference1. Mohle-Boetani JC, Farrar JA, Werner SB, Minassian D, Bryant R, Abbott S, et al . Escherichia coli O157 and Salmonella infections associated with sprouts in California, 1996–1998. Ann Intern Med. 2001;135:239-47. LinkGoogle Scholar Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoEscherichia coli O157 and Salmonella Infections Associated with Sprouts in California, 1996–1998 Janet C. Mohle-Boetani , Jeff A. Farrar , S. Benson Werner , Dzovag Minassian , Ray Bryant , Sharon Abbott , Laurence Slutsker , Duc J. Vugia , and Metrics 2 October 2001Volume 135, Issue 7Page: 550KeywordsSalmonella ePublished: 2 October 2001 Issue Published: 2 October 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...