tbuckley/cabot-search huggingface dataset:
The Improved Prognosis of Cryptococcal Meningitis with Amphotericin-B Therapy.
Authors: A. Spickard
Journal: Annals of Internal Medicine (1962)

s1 April 1962The Improved Prognosis of Cryptococcal Meningitis with Amphotericin-B Therapy.A. Spickard, M.D., W. Butler, M.D., J. P. Utz, M.D. (Assoc.)A. Spickard, M.D.Search for more papers by this author, W. Butler, M.D.Search for more papers by this author, J. P. Utz, M.D. (Assoc.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-56-4-691_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe discovery of amphotericin-B and its antifungal effect in cryptococcal meningitis in man has drastically changed the prognosis of this heretofore universally fatal disease. By analysis of 34 cases studied during the past seven years at the Clinical Center, this report attempts to define the beneficial effect of the drug and some of the factors that may influence response to treatment.Of the 34 cases studied, five received no amphotericin-B, and all died. Twenty-nine patients were treated with follow-up observation periods ranging from six months to over five years. Of these 29 cases, 22 had improvement subjectively and in their... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Bethesda, Md. (CS) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1962Volume 56, Issue 4Page: 691-691KeywordsAntifungalsCryptococcal meningitisDrugsFactor analysis Issue Published: 1 April 1962 PDF downloadLoading ...
Intracellular Metabolism and Effects of Circulating Cadmium-Metallothionein in the Kidney
Authors: Katherine S. Squibb, Bruce A. Fowler
Journal: Environmental Health Perspectives (1984)

The mechanism of cadmium-metallothionein (CdMT)-mediated nephrotoxicity is being studied in rats using an acute dose regimen. Results of metabolism studies have shown that injected CdMT is rapidly degraded by the kidney with the release of Cd2+ into the cell cytoplasm. Ultrastructural studies indicate that an increase in the number of small lysosomes is the first measurable effect of CdMT in the kidney at 1 hr. This is followed by an increase in the number of small vesicles at 4 hr. It is proposed that these effects are the result of decreased primary lysosome formation and an inhibition of the fusion of pinocytotic vesicles with cell lysosomes by Cd. Functional alterations measured 8 hr after CdMT injection include an increase in urine volume and increased excretion of the low molecular weight protein, RNAase. Prior induction of renal MT by Zn pretreatment prevents the induction of polyuria and low molecular weight proteinuria by CdMT. These data provide further evidence that CdMT nephrotoxicity occurs as a result of Cd2+ toxicity within the cell.
BEHAVIOR OF HYDROGEN SULPHID IN THE BODY
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
RATES FOR THE COLUMBUS MEETING.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Evaluation of a new antihypertensive agent: prazosin hydrochloride (Minipress)
Authors: M. E. Kosman
Journal: JAMA (1977)

Prazosin hydrochloride is an orally administered vasodilator that recently became available for the treatment of hypertension. It causes less tachycardia than hydralazine but may produce orthostatic hypotension, particularly after the initial dose. The role of prazosin in therapy is limited because of the risk of a first-dose syncopal reaction, and it appears to be indicated primarily in patients who cannot tolerate hydralazine hydrochloride or sympathetic depressant drugs. Like other antihypertensive agents, prazosin should be given with a diuretic. (<i>JAMA</i>238:157-159, 1977)
Aquatic versus Mammalian Toxicology: Applications of the Comparative Approach
Authors: Anthony M. Guarino
Journal: Environmental Health Perspectives (1987)

The large body of literature and techniques generated by mammalian toxicity studies provides a conceptual and technical framework within which the absorption, fate, and disposition of xenobiotics in aquatic organisms can be studied. This review emphasizes the similarities and differences between mammalian and aquatic systems, e.g., lung vs. gill as site of absorption and toxicity. These must be taken into consideration when designing aquatic toxicity studies. Studies of phenol red in dogfish shark as an example show physiologic-based pharmacokinetic modeling to be a useful tool for investigating and eventually predicting species differences in xenobiotic disposition and drug differences within the same species. This discussion demonstrates that both laboratory and modeling procedures are now available to carry out sophisticated studies of xenobiotic fate and disposition in fish. Such studies are needed to pinpoint sites and mechanisms of pollutant toxicity in aquatic organisms.
NARRATION
Authors: Ray Bunge
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Comparative Toxicity of Ambient Air Pollutants: Some Aspects Related to Lung Defense
Authors: Richard B. Schlesinger
Journal: Environmental Health Perspectives (1989)

Clearance mechanisms are an integral part of pulmonary defense, serving to rid the lungs of inhaled particles that deposit upon airway surfaces. This is accomplished by mucociliary transport in conducting airways and to a large extent by alveolar macrophages in the respiratory region. This paper compares the effects of acute exposure to sulfuric acid (H2SO4), nitrogen dioxide (NO2), or ozone (O3) on mucociliary clearance in rabbits and on phagocytic activity of macrophages recovered by bronchopulmonary lavage from animals exposed in vivo. The possible toxicologic mechanisms underlying dysfunction of clearance mediated by these irritants is discussed in terms of response to a pure acid (H2SO4), a pure oxidant (O3), and a material (NO2) that is a direct oxidant but which may produce secondary oxidants and acids upon dissolution in lung fluids.
ICU
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Food Inspection and Food Control
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Update: Influenza Activity—United States, September 28–November 29, 2008
Journal: JAMA (2009)

During September 28-November 29, 2008, influenza activity remained low in the United States. Of the few influenza viruses characterized thus far this season, most are antigenically related to the strains included in the 2008-09 influenza vaccine. Oseltamivir-resistant influenza A (H1N1) viruses have been detected, but currently available data are insufficient to predict their prevalence for the 2008-09 season. This report summarizes U.S. influenza activity since the last update and reviews new influenza vaccine recommendations for the current season.
Kunnumakkara AB, Nair AS, Ahn KS, et al. Gossypin, a pentahydroxy glucosyl flavone, inhibits the transforming growth factor beta-activated kinase-1-mediated NF-κB activation pathway, leading to potentiation of apoptosis, suppression of invasion, and abrogation of osteoclastogenesis. Blood. 2007;109(12):5112-5121.
Journal: Blood (2013)
Higher rate of cardiac events in patients with smaller hearts despite normal SPECT myocardial perfusion and normal left ventricular systolic function Sharad Bansal, Timothy M. Bateman, Iain A. McGhie, James H. O'Keefe, Jr., James A. Case, James S. Cullom, Kelly L. Moutray, Michael Coen. Mid America Heart Institute, Kansas City, MO
Journal: Journal of the American College of Cardiology (2001)
Sustained Virological Response to Treatment in Patients With Chronic Hepatitis C—Reply
Authors: Adriaan J. van der Meer, Bettina E. Hansen, Harry L. A. Janssen
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
US medical school finances
Authors: H. P. Jolly
Journal: JAMA (1985)

The 25th annual review of medical school finances, prepared by the Division of Operational Studies of the Association of American Medical Colleges (AAMC), is intended to reflect, through financial analysis of revenues and expenditures, the secular trends in medical education in the United States. Some sense of the growth in the enterprise during the 25-year interval from 1958-1959 to 1983-1984 may be gleaned from an examination of a few of its dimensions shown in Table 1. The number of schools has increased, the number of candidates for professional and academic doctorates have doubled and tripled, respectively, and the population of postdoctoral students has mushroomed. The number of full-time faculty has increased more than fivefold during this period. Expenditures for virtually all of the education, research, and service programs have expanded tenfold to 20-fold or more. All in all, the epoch covered by this time has been one of extraordinary growth.
Bored
Authors: Veneta Masson
Journal: Annals of Internal Medicine (2020)

Ad Libitum7 July 2020BoredVeneta Masson, MA, RNVeneta Masson, MA, RNSage Femme Press, Silver Spring, Maryland (V.M.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M19-1213 Audio Reading - “Bored” Audio. Michael A. Lacombe, MD, Annals Associate Editor, reads “Bored” by Veneta Masson, MA, RN Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail for DorotheaShe's just bored with itthis disease.She should have been gonemonths agodid all the last thingsbut didn't die in her sleeplike the doctor promisedand now there's a ceiling leakand a workman at the doorand the pain.No god to pray tono drug to distract herwhen it singson its one-string violinA friend tells her to think of it—the pain, the dying (she isn't sure)—as one more adventurein an adventurous life.So, at 80, shepulls herself upgathers herselfonce again opens the door Author, Article, and Disclosure InformationAffiliations: Sage Femme Press, Silver Spring, Maryland (V.M.)Current Author Address: Veneta Masson, MA, RN, Sage Femme Press, 15901 Woods Center Road, Silver Spring, MD 20906-1167; e-mail, veneta.[email protected]com. PreviousarticleNextarticle Advertisement Audio Reading - “Bored” Audio. Michael A. Lacombe, MD, Annals Associate Editor, reads “Bored” by Veneta Masson, MA, RN Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 7 July 2020Volume 173, Issue 1Page: 9KeywordsDrugsSleep ePublished: 7 July 2020 Issue Published: 7 July 2020 Copyright & PermissionsCopyright © 2020 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
INTRAPELVIC EXTRAVASATION OF URINE.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Improving access to health care through physician workforce reform. Directions for the 21st century
Authors: M. L. Rivo
Journal: JAMA (1993)

THE COUNCIL on Graduate Medical Education (COGME) was authorized by Congress in 1986 to provide an ongoing assessment of physician supply trends and to recommend appropriate federal and private sector efforts to address identified needs. In its first report to the Health and Human Services Secretary and Congress in 1988, the COGME expressed concerns that physician specialty and geographic maldistribution were growing despite an increasing aggregate supply of physicians. Then, concerns about the physician workforce, health care access, and rising costs had not yet been prominently thrust into the national spotlight. The social context of the council's Third Report, released in October 1992, is vastly different. The health care system is acknowledged to be in a crisis and health care reform is actively being considered. Health care expenditures exceeded $650 billion in 1990 and are projected to reach $1 trillion in 1995. Thirty-five million Americans remain medically uninsured and millions
Notice.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BOOK REVIEWS
Authors: H. CHECKOWAY
Journal: JNCI Journal of the National Cancer Institute (1991)

Journal Article BOOK REVIEWS Get access Occupational Cancer Epidemiology, Recent Results in Cancer Research . Pierre Band , ed. New York : Springer-Verlag , 1990 , 193 pp.$69. HARVEY CHECKOWAY HARVEY CHECKOWAY Department of Environmental Health University of Washington School of Public Health and Community Medicine1705 Pacific Ave., N.E. Seattle, WA 98105 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 13, 3 July 1991, Page 958, https://doi.org/10.1093/jnci/83.13.958 Published: 03 July 1991
Curso práctico de fisiología
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal