Thyrocalcitonin
Authors: J. L. H. O'RIORDAN
Journal: Annals of Internal Medicine (1967)

Editorial Notes1 October 1967ThyrocalcitoninJ. L. H. O'RIORDAN, M.R.C.P.J. L. H. O'RIORDAN, M.R.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-67-4-903 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA year ago in the ANNALSMunson (1) reviewed the properties of thyrocalcitonin, and more recently the subject was discussed at length at a symposium in London (2). From its behavior during purification it seemed likely that thyrocalcitonin was a protein; this has now been confirmed in studies in which treatment with peptidases was shown to destroy activity (3). However, it is clear (4, 5) that the initial preparations of thyrocalcitonin (6) were only partially purified and that the molecule is smaller than first reported. One indication of this was obtained in studies of the distribution of the hypocalcemic activity...References1. MUNSON PL: Thyrocalcitonin. Ann. Intern. Med. 64: 1353, 1966. LinkGoogle Scholar2. TAYLOR SF (editor): Calcitonin. Proceedings of a Symposium held July 17-20, 1967. William Heineman (Medical Books) Ltd., London, in press. Google Scholar3. TASHJIANWARNOCK AHDR: Stability of the hypocalcaemic activity of porcine thyrocalcitonin. Endocrinology. 81: 306, 1967. CrossrefMedlineGoogle Scholar4. POTTSREISFELDHIRSCHWASTHEDVOELKELMUNSON JTRAPFABEFPL: Purification of porcine thyrocalcitonin. Proc. Nat. Acad. Sci. USA. 58: 328, 1967. CrossrefMedlineGoogle Scholar5. HAWKERRASMUSSENARNAUDGLASS CDHCDJD: Isolation of porcine thyrocalcitonin. Fed. Proc. 26: 392, 1967. Google Scholar6. TENENHOUSEARNAUDRASMUSSEN ACCH: The isolation and characterization of thyrocalcitonin. Proc. Nat. Acad. Sci. USA 53: 818, 1965. CrossrefMedlineGoogle Scholar7. O'RIORDANTASHJIANMUNSONCONDLIFFEAURBACH JLAHPLPGGD: Thyrocalcitonin: ultracentrifugation in gradients of sucrose. Science 154: 885, 1966. CrossrefMedlineGoogle Scholar8. COPPCOCKROBTKUEH DHDWY: Ultimobranchial origin of calcitonin. Hypocalcaemic effects of extracts from chicken glands. Canad. J. Physiol. Pharmacol. In press, November 1967. CrossrefMedlineGoogle Scholar9. PEARCECARVALHEIRA AGAF: Cytochemical evidence for an ultimo-branchial origin of rodent thyroid C cells. Nature (London) 214: 929, 1967. CrossrefMedlineGoogle Scholar10. BUSOLATIPEARSE GAG: Immuno-fluorescent localization of calcitonin in the C cells of pig and dog thyroid. J. Endocr. 37: 205, 1967. CrossrefMedlineGoogle Scholar11. WILLIAMSHARGISGALLOWAYHENDERSON GMGAWBWJ: Evidence for thyrocalcitonin in man. Proc. Soc. Exp. Biol. Med. 122: 1273, 1966. CrossrefMedlineGoogle Scholar12. FOSTERJOPLINMACINTYREMELVINSLACK GVGFLKEE: Effect of thyrocalcitonin in man. Lancet 1: 107, 1966. CrossrefMedlineGoogle Scholar13. FOSTERDOYLEBORDIERMATRAJT GVFHPH: Effects of thyrocalcitonin on bone. Lancet 2: 1428, 1966. CrossrefMedlineGoogle Scholar14. MILHAUDPERAULTMOUKHTAR GAMMS: Etude du mécanisme de l'action hypocalcémiante de la thyrocalcitonine. C. R. Acad. Sci. (Paris) 261: 813, 1965. Google Scholar15. O'RIORDANAURBACH JLGD: Mode of action of thyrocalcitonin, 1967. In preparation. Google Scholar16. MAZZUOLICOENBASCHIERI GFGL: Thyrocalcitonin-excess syndrome. Lancet 2: 1192, 1966. CrossrefGoogle Scholar17. CHIMENESKLOTZ HHP: Thyrocalcitonin-excess syndrome. Lancet 1: 111, 1967. CrossrefGoogle Scholar18. ALIAPOULIOSVOELKELMUNSON MAEFPL: Assay of human thyroid glands for thyrocalcitonin activity. J. Clin. Endocr. 26: 897, 1966. CrossrefGoogle Scholar19. TASHJIANFRANTZLEE AHACJB: Pseudohypoparathyroidism: assays of parathyroid hormone and thyrocalcitonin. Proc. Nat. Acad. Sci. USA 56: 1138, 1966. CrossrefMedlineGoogle Scholar20. GITTESMUNSONTOVERUD RFPLSU: Effects of plasma calcium on the thyrocalcitonin content of rat thyroid glands. Fed. Proc. 25: 496, 1966. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Medicine The Middlesex Hospital London, W.I. England PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByReferencesCalcitonin—A Progress ReportJ. L. H. O'RIORDAN, M.R.C.P. 1 October 1967Volume 67, Issue 4Page: 903-904KeywordsBehaviorProteins Issue Published: 1 October 1967 PDF DownloadLoading ...