tbuckley/cabot-search huggingface dataset:
Differences in hepatic processing of dietary and intravenously administered copper in rats
Authors: M Dijkstra
Journal: Hepatology (1997)

The biliary pathway represents the major excretory route for copper (Cu). It has been suggested that glutathione (GSH) plays a role in this process. However, biliary secretion of endogenous Cu is unaffected in canalicular multispecific organic anion transporter (cmoat)/multi-drug resistance protein (mrp2)-deficient GY/TR- rats, which is a mutant rat strain expressing defective canalicular adenosine triphosphate (ATP)-dependent GSH-conjugate transport and which is unable to secrete GSH into bile. Secretion of Cu after iv Cu load is markedly impaired in GY/TR- rats when compared with normal Wistar (NW) rats. Administration, iv, of 65, 325, or 2300 nmol/100 g body wt CuSO4 dose-dependently increased Cu secretion in normal Wistar (NW) rats. Secretion rates in GY/TR rats were much lower and plateaued with higher loads at a level of about 35 nmol/h/100 g body wt. Clearance of an intravenous (iv) bolus of 64Cu (250 nmol/100 g body wt) was faster in GY/TR- rats than in controls, but secretion of 64Cu into bile was clearly reduced in the mutants. Specific activity of biliary Cu was similar in both groups. To investigate the removal of excess dietary Cu via bile, GY/TR and NW rats received water supplemented with Cu (CuSO4 8 mmol/L) for up to 12 weeks (Cu-fed) or tap water (controls). Cu feeding resulted in an increase of biliary Cu secretion from ∼ 6 to ∼ 30 nmol/h/100 g body wt within two weeks, both in NW and GY/TR- rats; Cu secretion also did not further increase during the course of the experiment. Hepatic Cu content was similar in NW and GY/TR- rats and progressively increased during Cu feeding. Our data indicate that biliary secretion of diet-derived Cu proceeds exclusively via a saturable Cu transporting system, which is distinct from cmoat/mrp2 and which is independent of biliary GSH. This transport may be mediated by the recently identified Cu-ATPase. In contrast, excess hepatic Cu after iv Cu load depends on cmoat/mrp2 activity for rapid removal. It is concluded that iv administered and dietary (endogenous) Cu is, in part, processed differently by rat liver, which might be related to differences in Cu redox state.
Some benefit of concurrent chemo-radiotherapy in cancer
Authors: T. Hager
Journal: JAMA (1983)

Simultaneous radiotherapy and chemotherapy may be useful in the treatment of both limited small-cell lung cancer and advanced Hodgkin's disease, according to reports presented at the recent meeting of the American Society of Clinical Oncology in San Diego. This adds to the evidence already gathered on the efficacy of this combination therapy in other types of cancer, such as breast cancer (<i>JAMA</i>[MEDICAL NEWS] 1982;248:1799-1801). Although such combined use of drugs and radiation therapy (RT) sometimes results in an increase in adverse effects in patients, the benefits of these new, more intensive regimens may outweigh the dangers in some patients. A multicenter randomized trial conducted by the Southeastern Cancer Study Group, Birmingham, Ala, has shown that administering thoracic radiation therapy simultaneously with chemotherapy can improve results in the treatment with limited small-cell carcinoma of the lung. A total of 304 patients were divided into two groups, matched by age and
Abstract 3444: Identification of Interleukin-1 (IL-1) induced gene expression pattern in breast cancer (BCa) cells
Authors: Afshan Fathima Nawas, Mohammed Kanchwala, Shayna Thomas-Jardin, Vanessa Anunobi, Ally Wong, Chao Xing, Nikki Delk
Journal: Cancer Research (2019)

Abstract Breast cancer (BCa) and prostate cancer (PCa) are both hormone driven cancers with similar etiology and tumor microenvironment inflammation promotes BCa and PCa progression. Interleukin-1 (IL-1) is an inflammatory cytokine present in the tumor microenvironment and IL-1 is elevated in BCa and PCa patient tumor and/or blood serum and correlates with poor prognosis. We have shown that IL-1 represses the BCa and PCa therapeutic targets, Estrogen Receptor Alpha (ERa) and Androgen Receptor (AR), respectively, in PCa and BCa cell lines; yet the cells remain viable. Thus, IL-1 may promote treatment resistance and disease progression. The pro-survival protein Sequestome-1 (SQSMT1/p62) is also upregulated in both BCa and PCa cell lines exposed to IL-1, suggesting that BCa and PCa cells have evolved a shared response to IL-1 and hormone receptor loss. RNA sequencing of an IL-1-treated PCa cell line revealed an IL-1-modulated gene suite predicted to confer AR-independent tumorigenicity. We performed RT-qPCR in PCa cell lines for several select genes to confirm the RNA sequencing results and given the similar etiology and IL-1 regulation of ERa, AR, and p62 expression in BCa and PCa cell lines, we presumed that our select genes would be similarly regulated by IL-1 in BCa cells. However, outside of ERa, AR, and p62 expression, our select genes did not show similar IL-1 regulation in BCa cell lines, suggesting that IL-1 regulates a unique set of genes that could contribute to ERa-independent tumorigenicity in BCa cells. Therefore, to identify a BCa-specific IL-1-modulated gene suite, we performed RNA sequencing on an IL-1-treated ERα+ BCa cell line and compared gene expression changes with 1) basal gene expression in an ERa- BCa cell line and 2) our IL-1-modulated PCa-specific gene suite. Our bioinformatics analysis revealed pathways that are predicted to promote ERa-independent tumorigenicity in BCa cells and investigations are underway to demonstrate the functional significance of our gene expression data. Taken together, our studies provide insight into the mechanistic function of IL-1 in PCa and BCa resistance to hormone receptor-targeted therapies and tumor progression. Citation Format: Afshan Fathima Nawas, Mohammed Kanchwala, Shayna Thomas-Jardin, Vanessa Anunobi, Ally Wong, Chao Xing, Nikki Delk. Identification of Interleukin-1 (IL-1) induced gene expression pattern in breast cancer (BCa) cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3444.
Sixth Annual Meeting of the American College of Epidemiology
Journal: JNCI Journal of the National Cancer Institute (1987)

Sixth Annual Meeting of the American College of Epidemiology Get access JNCI: Journal of the National Cancer Institute, Volume 78, Issue 4, April 1987, Page 786, https://doi.org/10.1093/jnci/78.4.786 Published: 01 April 1987
SAN FRANCISCO'S PLAGUE.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ORIGINAL ARTICLES.
Authors: Wm. B. Atkinson
Journal: JAMA (1884)

<h3>AMERICAN MEDICAL ASSOCIATION.</h3> Thirty-fifth Annual Meeting, held in Washington, Tuesday, Wednesday, Thursday, and Friday, May6, 7, 8,and9, 1884. TUESDAY — FIRST DAY. The meeting was called to order in the Congregational Church, at the corner of Tenth and G Streets, at 10:30 A. M., by the Chairman of the Committee of Arrangements, Dr. A. Y. P. Garnett. After prayer by the Rev. William A. Leonard, D.D, the Chairman introduced the President of the Association, Dr. Austin Flint, of New York. The Vice-Presidents, Dr. R. A. Kinloch, South Carolina; Dr. T. B. Lester, Mo.; Dr. A. L. Gihon, U. S. N.; Dr. S. C. Gordon, Me.; the Permanent Secretary, Dr. W. B. Atkinson, Pa.; the Assistant Secretary, Dr. D. W. Prentiss, D. C.; the Treasurer, Dr. R. J. Dunglison, Pa.; and the Librarian, Dr. C. H. A. Kleinschmidt, D. C., were also present. Dr. Garnett addressed the Association
Transplant-Transmitted Encephalitis
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ROENTGENOGRAPHIC CHARACTERISTICS OF LESIONS OF BONE
Journal: JAMA (1929)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE HISTORY OF MEDICINE REVISED
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Private practice by residents in training
Authors: D. A. Boyd
Journal: JAMA (1967)

Private practice for fee by residents, in either general or specialty areas, has been called colloquially "moonlighting." My attention was drawn to this by observation that it appeared to be quite extensive in some localities. Some residency training programs were on a 40-hour week, and the trainee used much of the remaining time in private practice. To my knowledge, one enterprising resident established a flourishing clinic and employed ancillary personnel. To ascertain the extent of such practices, a survey of all specialty boards was undertaken. A large majority of the boards reported that this was not a problem in their field as far as they knew. Only four of those responding stated that they had a definite policy prohibiting such practice. The remainder indicated that they had no policy regarding this, many stating that although it had never been discussed, it was a personal opinion of the writer that such
The quality of life of hemodialysis recipients treated with recombinant human erythropoietin. Cooperative Multicenter EPO Clinical Trial Group
Authors: R. W. Evans
Journal: JAMA (1990)

Initial clinical trials with recombinant human erythropoietin provided evidence of a quality-of-life benefit for patients with anemic end-stage renal disease who received maintenance hemodialysis. As part of a phase III clinical trial of recombinant human erythropoietin, the quality of life of patients was systematically assessed. More than 300 patients at nine dialysis centers were evaluated. A statistically significant improvement was established between baseline and second follow-up on most objective and subjective quality-of-life parameters, including energy and activity level, functional ability, sleep and eating behavior, disease symptoms, health status, satisfaction with health, sex life, well-being, psychological affect, life satisfaction, and happiness. No change was observed in ability to work or employment status. We conclude that, in addition to substantial improvement in hematologic parameters, recombinant human erythropoietin greatly enhances the quality of life of anemic patients who receive maintenance hemodialysis. (<i>JAMA</i>. 1990;263:825-830)
Roentgenographic findings in PEEP therapy. Indicators of pulmonary complications
Authors: A. R. Altman
Journal: JAMA (1979)

We reviewed serial chest roentgenograms of 82 patients treated with positive end-expiratory pressure (PEEP) therapy for morbid pulmonary failure. No change was identified in the appearance of the chest roentgenograms in 49 patients. Thirty-three patients showed pulmonary hyperinflation, varying degrees of apparent clearing of alveolar or interstitial disease, and resorption of interstitial and pleural fluid. Lung hyperinflation and interstitial gas generally preceded pneumomediastinum and pneumothorax. These pulmonary complications were identified roentgenographically, often before they became clinically apparent. No consistent correlation was observed between these roentgenographic changes and the ventilatory pressures employed. The radiologist should be informed that a patient is receiving PEEP therapy, as the earliest signs of alveolar rupture—interstitial emphysema—are frequently subtle. (<i>JAMA</i>242:727-730, 1979)
THE IMPORTANCE OF RESISTANCE TO TUBERCULOSIS.
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TOC 6th page
Authors: Naoko Inomata, Hiroyuki Osuna, Zenro Ikezawa, Kim Peeters, Andre Knulst, Frank Rynja, Carla Bruijnzeel-Koomen, Stef Koppelman, Y Breast-Feeding, Atopy, Undurti Das, Y Reply, Patricia Chulada, Michelle Carey, Darryl Zeldin, Vasanthi Siruguri, Ramesh Bhat, India Reply, Steven Sutton, Amal Assa'ad, Christine Steinmetz, Marc Rothenberg, Qutayba Hamid, Bruce Mazer, Burton Zweiman
Journal: Journal of Allergy and Clinical Immunology (2004)
Letter to the editor
Authors: Camilo E Fadul, Jan L Fisher, Thomas H Hampton, Marc S Ernstoff
Journal: Journal for ImmunoTherapy of Cancer (2014)

May 8, 2014 Pedro Romero, M.D. Editor-in-Chief Journal for ImmunoTherapy of Cancer Dear Dr. Romero, We read with interest the work by Olin and collaborators published in the Journal for ImmunoTherapy of Cancer under the title “Vaccination with dendritic cells loaded with allogeneic brain
Paroxysmal atrial fibrillation in a physically active man
Authors: Michael Carethers
Journal: JAMA (1988)

<h3>To the Editor.—</h3> It seems that despite the clear history, the consultant has failed to consider that alcohol may be the culprit in triggering paroxysmal atrial fibrillation (AF) in this 63-year-old male athlete.<sup>1</sup>The submitter of the question stated that AF occurred after consumption of a "substantial amount of wine," which was paraphrased by the consultant into "moderate amount of alcohol." Neither defines what is "substantial" or "moderate." Even in the absence of overt heart disease, a "substantial" consumption of alcohol may induce acute AF.<sup>2</sup>Up to 35% of patients presenting with net onset AF at a public hospital were intoxicated with alcohol.<sup>3</sup>The AF in the patient in question may have spontaneously reverted to normal sinus rhythm after the alcohol effect on the heart waned. Current thoughts of possible mechanisms of how alcohol could cause arrhythmias include (1) alcohol-promoted secretion of epinephrine and norepinephrine by the
Prospective pooled analysis of six phase III trials investigating duration of adjuvant (adjuv) oxaliplatin-based therapy (3 vs 6 months) for patients (pts) with stage III colon cancer (CC): The IDEA (International Duration Evaluation of Adjuvant chemotherapy) collaboration.
Authors: Qian Shi, Alberto F. Sobrero, Anthony Frank Shields, Takayuki Yoshino, James Paul, Julien Taieb, Ioannis Sougklakos, Rachel Kerr, Roberto Labianca, Jeffrey A. Meyerhardt, Franck Bonnetain, Toshiaki Watanabe, Ioannis Boukovinas, Lindsay A. Renfro, Axel Grothey, Donna Niedzwiecki, Valter Torri, Thierry Andre, Daniel J. Sargent, Timothy Iveson
Journal: Journal of Clinical Oncology (2017)

LBA1 The full, final text of this abstract will be available at abstracts.asco.org at 7:30 AM (EDT) on Sunday, June 4, 2017, and in the Annual Meeting Proceedings online supplement to the June 20, 2017, issue of the Journal of Clinical Oncology. Onsite at the Meeting, this abstract will be printed in the Sunday edition of ASCO Daily News.
Caring
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
LETTER FROM BALTIMORE.
Authors: None E. F. C.
Journal: JAMA (1891)

The Admission of Women to the Johns Hopkins Medical School—The Historical Club—Death of Dr. John R. Quinan—Semi-Annual Meeting of the Medical and Chirurgical Faculty. You have already been informed by me of the success of the movement inaugurated in this city about the first of last May, for raising a fund of $100,000 to secure the admission of women into the Johns Hopkins Medical School upon the same terms as men. This cannot but be regarded as marking an epoch in the literary and professional advancement of women. With a courage and an aspiration which was not to be daunted by prejudice or opposition, the managers of the project, stimulated by that determined advocate of educational equality, Miss Mary Garrett, boldly knocked at the door of the most modern and advanced of American colleges, "an institution," in the language of President Stanley Hall, of Clark University, "which in the less
BOOK REVIEWS
Journal: Circulation Research (1960)

The last monograph on the anatomy and histology of the lung' was published by William Snow Miller in 1947.This more recent monograph by von Hayek is similar in coverage, but the following differences between the 2 monographs can be noted: (a) inclusion of electron microscopy of the lung, which did not appear even in the original German version of von Hayek's book; (b) addition of chapters in this book on extrapulmonary structures such as the chest wall, ribs and diaphragm ; (c) review of bronchopulmonary segments; (d) emphasis on "Sperrarterien."The latter refers to the anastomotic vascular channels between the bronchial and pulmonary arteries, which may in turn give branches to the bronchi and alveoli, and even serve as arteriovenous anastomoses.Many readers will be inclined to accept the existence of "Sperrarterien" except those who will find it difficult to forget the failure by Miller to find similar anastomoses.