tbuckley/cabot-search huggingface dataset:
Regional Left Ventricular Systolic Function in Humans During Off-Pump Coronary Bypass Surgery
Authors: Philip M. Brown, Victor B. Kim, Bret J. Boyer, Robert M. Lust, W. Randolph Chitwood, Joseph R. Elbeery
Journal: Circulation (1999)

Background —Controversy exists as to whether off-pump CABG with local occlusion results in clinically significant myocardial ischemia during the occlusion period. This study was undertaken to delineate the effects of transient local coronary artery occlusion on regional systolic function. Methods and Results —Eight consenting patients undergoing left internal mammary to left anterior descending coronary artery (LAD) bypass were instrumented with a left ventricular pressure catheter and 2 subepicardial cylindrical ultrasonic dimension transducers placed in the minor axis dimension in the region served by the LAD. A digital sonomicrometer was used to collect data before, during, and after coronary occlusion from which percent systolic shortening and pressure-dimension loops were derived. Measuring devices were removed immediately after the final time point. All patients tolerated the procedure well, and there were no complications. Average duration of local occlusion needed for CABG was 15.9±4.4 minutes (range, 12 to 26 minutes). Local occlusion was associated with a decrease in peak systolic shortening from 5.8±0.8% to 1.8±0.8%. In all cases, function returned to baseline after restoration of flow. Pressure-dimension loops confirmed these findings and no evidence of diastolic creep. Linear repression analysis of degree of stenosis versus change in segmental shortening revealed a significant inverse correlation. Conclusions —Local occlusion of the LAD resulted in a transient decrease in myocardial function during occlusion with complete recovery during reperfusion. This change was less significant with increasing degrees of coronary stenosis. These data suggest that local occlusion is not associated with permanent myocardial injury but that ischemic changes do occur that may be clinically significant, especially in patients with lesser degrees of coronary stenosis.
Environmental Florence Nightingales: Nursing's New Front Line
Authors: Julie Wakefield
Journal: Environmental Health Perspectives (2001)

Nurses comprise the largest health professional group in terms of number, and they can be found in almost every health care setting, including homes, schools, work sites, and hospitals. To a large extent, nurses have always been aware of environmental factors when doing their job, but the definition of environmental health nursing is being expanded. Today, in addition to considering the possibility of environmental influences when taking patient health histories, evaluating symptoms, and conducting community assessments, nurses may change environmental conditions of affected individuals or populations through direct care, teaching, advocacy, and public policy initiatives. Nurses are helping patients evaluate the relative risks of various types of environmental exposures, such as lead. And they are also playing a key role in establishing a national tracking system of environmental health as well as in conducting patient research.
Gastric Cancer
Authors: W. Lawrence
Journal: CA A Cancer Journal for Clinicians (1986)

A blood have a 15 to 20 percentincrease in incidence of thiscancer.4A studyof Japaneseimmigrants, however,seems to contradict the genetic influence theory.5Japanese immigrants to the US maintain nearly the same incidence of gastric cancer as that of the region where they spent their first 20 years of life; the offspring of these same immigrants, however, show an in cidence comparable to that of the native Americans in the same area.These find ings suggest that dietary or other exposures 216 CA-A CANCERJOURNALFORCLINICIANS GastricCancer
Primary Aldosteronism
Authors: Arunabha Ganguly
Journal: New England Journal of Medicine (1998)

Primary aldosteronism resulting from an adrenocortical adenoma (aldosteronoma), as described by Conn,1 is one of a few potentially curable forms of hypertension. Aldosteronoma is the most common cause of primary aldosteronism. Aldosteronomas are usually small (less than 2 cm in diameter), are benign, and have a golden yellow color on their cut surfaces (Figure 1), with different adrenal-cell types visible on microscopy. Idiopathic aldosteronism, which is associated with bilateral micronodular or macronodular adrenal hyperplasia, constitutes 20 to 30 percent of cases of primary aldosteronism,28 although it is considered by some to be a variant of essential hypertension.9 Unilateral adrenal . . .
Mitochondrial DNA in the Sea Urchin Arbacia lixula: Evolutionary Inferences from Nucleotide Sequence Analysis
Authors: De Georgi et al, De Georgi et al
Journal: Molecular Biology and Evolution (1991)

In the article "Isolation and Molecular Evolutionary Analysis of a Cytochrome c Gene from Oryza sativa (Rice)" by Kemmerer et al., published in the March 1991 issue of A4oleculur Biology and Evolution (8:2 12-226), K1 values in table 1 are actually the number of substitutions per 1,000 zerofold degenerate sites (& X 1,000).Therefore, the title of table 1 should read "Number of Substitutions per 1,000 Zerofold Degenerate Sites."This change applies to figures 5 and 7, as well as to all K, values mentioned in this paper, with the exception of the second paragraph on page 2 19.K, values can be calculated by using the two-parameter formula of Kimura (Proc.
Biliary/pancreas free papers 150-166
Authors: S Parry, J Barton, M Welfare, I Mohammed, L Cherkas, S Riley, T Spector, N Trudgill, S Lal, J Mclaughlin, G Giampaolo, G Dockray, A Varro, D Thompson, J Jones, D Kendall, P Millns, C Hawkey, S Dunlop, D Jenkins, R Spiller, L Gregory, L Yaguez, S Coen, E Amaro, S Smale, A Hobson, S Williams, Q Aziz, V Chudleigh, E Brennan, S Tarry, S Myers, S Lewis, G Smith, K Palmer, Z Khan, E Simpson, A Cole, I Macdonald, D Pye, A Austin, J Freeman
Journal: Gut (2002)

Introduction: Previous studies, many uncontrolled, suggest 4 to 32% of people develop irritable bowel syndrome (IBS) after ID.Little information is available on the development of other FGIDs after ID.Aim: To determine if patients with stool culture confirmed bacterial diarrhoea were more likely to develop gut symptoms consistent with a diagnosis of IBS, functional dyspepsia or functional diarrhoea at 3 and 6 month follow up compared with community controls.Methods: A prospective community-based case-control study over one year.Subjects with stool positive bacterial infectious diarrhoea and control subjects from the same primary care practice were invited to participate.The presence or not of IBS, functional dyspepsia or functional diarrhoea was diagnosed at the start and at follow up using self-complete Rome II modular questionnaires.The diagnosis of a baseline FGID excluded subjects from continuing.There were 128 cases and 219 community controls eligible and who consented to participate.Results: At follow up there was a higher incidence of FGIDs in the cases compared with controls, mainly due to a higher incidence of IBS (see table ).There was no difference in the incidence of functional dyspepsia between cases and controls.Conclusions: IBS and functional diarrhoea is diagnosed more frequently in people at three and six-month follow up after an episode of stool positive bacterial diarrhoea compared with community controls despite careful exclusion of people with pre-existing FGIDS and adds further support for the concept of post-infectious IBS.
Massachusetts Medical Society
Authors: John Figgis Jewett
Journal: New England Journal of Medicine (1958)

COMMITTEE ON MATERNAL WELFAREPost-Partum Hemorrhage Due to Uterine AtonyA 90.7-kg. (200-pound), thirty-year-old gravida 5, para 4, was admitted to the hospital at the twenty-sixth week because of vaginal bleeding. This subsided quickly. Bed rest, sedation, bioflavonoids, vitamin K and iron were prescribed, but anemia persisted on discharge eleven days later, the hemoglobin having risen from 65 per cent to 78 per cent (Sahli). She was not examined, the diagnosis being "probable marginal placenta praevia."Slight bleeding recurred two weeks later, and she was readmitted to the hospital, being seen by a consultant two hours later when there was . . .
265O Anlotinib in locally advanced or metastatic radioiodine-refractory differentiated thyroid carcinoma: A randomized, double-blind, multicenter phase II trial
Authors: Y. Chi, M. Gao, Y. Zhang, F. Shi, Y. Cheng, Z. Guo, M. Ge, J. Qin, J. Zhang, Z. Li, X. Zhou, R. Huang, X. Chen, H. Liu, R. Cheng, Z. Xu, X. Zheng, D. Li, P. Tang
Journal: Annals of Oncology (2020)
Massachusetts Medical Society
Authors: John Figgis Jewett
Journal: New England Journal of Medicine (1962)

COMMITTEE ON MATERNAL WELFARE*Third-Trimester Bleeding, Followed by Fatal ShockA thirty-one-year-old gravida 7, para 4, entered the hospital at thirty-two weeks after bleeding vaginally for two hours. She was pale and weak; no blood pressure or pulse was perceptible until 500 ml. of blood had been administered. A Kerr cesarean section was then performed while another unit of blood was given and with the systolic blood pressure stabilized between 80 and 100. An active infant weighing 1843 gm. (4 pounds, 1 ounce) was delivered but lived for only three days. Blood found in the uterus had clotted as did . . .
The Role of Human Glutathione Transferases and Epoxide Hydrolases in the Metabolism of Xenobiotics
Authors: Janeric Seidegard, Gunilla Ekstrom
Journal: Environmental Health Perspectives (1997)

Human glutathione transferases (GSTs) are a multigene family of enzymes that are involved in the metabolism of a wide range of electrophilic compounds of both exogenous and endogenous origin.GSTs are generally recognized as detoxifying enzymes by catalyzing the conjugation of these compounds with glutathione, but they may also be involved in activation of some carcinogens.The mammalian GSTs can be differentiated into four classes of cytosolic enzymes and two membrane bound enzymes.Human epoxide hydrolases (EHs) catalyze the addition of water to epoxides to form the corresponding dihydrodiol.The enzymatic hydration is essentially irreversible and produces mainly metabolites of lower reactivity that can be conjugated and excreted.The reaction of EHs is therefore generally regarded as detoxifying.The mammalian EHs can be distinguished by their physical and enzymatic properties.Microsomal EH (mEH) exhibits a broad substrate specificity, while the soluble EH (sEH) is an enzyme with a "complementary" substrate specificity to mEH.Cholesterol EH and leukotriene A4 hydrolase are two EHs with very limited substrate specificity.The activities of either GSTs or EHs expressed in vivo exhibit a relatively large interindividual variation, which might be explained by induction, inhibition, or genetic factors.These variations in levels or activities of individual isoenzymes are of importance with respect to an individual's susceptibility to genotoxic effects.This article gives a general overview of GSTs and EHs, discussing the modulation of activities, determination of these enzymes ex vivo, and the polymorphic expression of some isoenzymes.
Rotation of Photograph.
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Disseminated Fusariosis
Authors: Jacques Sevestre, Lora Kopec
Journal: New England Journal of Medicine (2020)

An 8-year-old boy undergoing treatment for relapsing B-cell leukemia presented with subcutaneous nodules on the trunk, arms, and legs. A biopsy specimen showed septated hyphae and spores. The fungus Fusarium dimerum was identified in culture.
An Oration Delivered before the Hunterian Society
Authors: T. Bryant
Journal: BMJ (1870)

WHEN this Society was instituted, fifty years ago, " for the promotion of medical and clhirurgical science"; its name, " Hunterian", selected; and the motto chosen, " Ratio Societatis vinculum"-its founders had clearly before them, as leading practical truths, that the practice of our profession should be based on science; that it should be pursued in the spirit which animated the immortal John Hunter; and that its claims upon public estimation should be mainly those of reason.They saw the value of cooperation in the pursuit of these high objects, by feeling its wants; and they consequently gave it effect.They started with a high prin- ciple to guide them, and invoked the spirit of the great physiologist and surgeon, John Hunter, to help them to compass their ends; and they bound their small professional society together, as they deemed the larger society of mankind should always be bound together, by the im- mutable and godlike, because god-begotten, power-the bond of reason.The objects were noble, and deserved success; and the means em- ployed for carrying them out seem likewise to have been judicious.Let us now, therefore, on this the first general neeting of the Society after the lapse of the first fifty years of our Society's existence, stop, ere we start again on our onward course, to inquire what success has attended our efforts during the long years that have passed-in what points weakness has been displayed, and in what strength; to take stock, as it were, of our professional capital, to see what we have gained and what we have lost, in order that we may form a just conception of the work which we have in hand, and gain some hints as to the paths into which our future labours should be directed.And surely, in doing this, we can but be carrying out the practical objects for which this annual oration must have been founded; for we have it on the authority of our first president and orator, Sir WV.Blizard, that this Society was established, " not in the spirit of.JiAlberal opposi-
Tetracycline treatment of chloroquine-resistant falciparum malaria in Thailand
Authors: E. J. Colwell
Journal: JAMA (1972)

Tetracycline hydrochloride was evaluated in asymptomatic and acutely ill subjects naturally infected with chloroquine resistant strains of<i>Plasmodium falciparum</i>. Sixteen asymptomatic subjects of whom eight had recently experienced chloroquine treatment failures received 250 mg of tetracycline hydrochloride, four times daily for ten days. A presumptive radical cure was demonstrated in 12. In the other four, treatment was discontinued within 72 hours because of symptomatic development. Acutely ill subjects were assigned to one of two treatment groups. One group received 640 mg of quinine sulfate, three times daily for three days, followed by 250 mg of tetracycline hydrochloride, four times daily for ten days. The other group received a similar course of quinine followed by a conventional course of chloroquine. A presumptive radical cure was demonstrated in 29 of 30 treated with the quinine-tetracycline regimen, and in 15 of 36 treated with the quinine-chloroquine regimen.
Genes and pathophysiology of type 2 diabetes: more than just the Randle cycle all over again
Authors: Alan R. Shuldiner, John C. McLenithan
Journal: Journal of Clinical Investigation (2004)

The Randle cycle, which has been invoked to explain the reciprocal relationship between fatty acid oxidation and glucose oxidation, has long been implicated as a potential mechanism for hyperglycemia and type 2 diabetes mellitus (T2DM). Now genetic, functional genomic, and transgenic approaches have identified PPARγ coactivators (PGC-1α and PGC-1β) as key regulators of mitochondrial number and function. They regulate adaptive thermogenesis as well as glucose and fat oxidation in muscle and fat tissue, gluconeogenesis in liver, and even glucose-regulated insulin secretion in β cells. PGC-1α and PGC-1β mRNA levels and the mitochondrial genes they regulate are decreased in muscle of people with prediabetes and T2DM. A new report indicates that PGC-1α and PGC-1β mRNA levels decrease with age in individuals with a genetic variant in PGC-1α, and these decreases correlate with alterations in whole-body glucose and fatty acid oxidation. These findings provide insights into how aging modifies genetic susceptibility to alterations in oxidative phosphorylation and T2DM.
Carotid/femoral ultrasound morphology screening and effects of vitamin C on cardiovascular events and vascular disease progression in low-risk subject. A 10-year follow-up study Maria Rosaria Cesarone, Marco Bucci, Mariateresa De Sanctis, Lucrezia Incandela, Maura Griffin, Surinder Dhanjil, Ganesh Ramaswami, George Geroulakos, Adam Carey, Antonio Barsotti, Giovanni V. Belcaro, Andrew N. Nicolaides. Biomedical Sciences Department, University of Chieti, Chieti, Italy, Irvine Lab. St. Mary's …
Journal: Journal of the American College of Cardiology (2001)
P47: Improving treatment outcomes for leprosy in Pernambuco, Brazil: a qualitative study exploring the experiences and perceptions of retreatment patients and their carers
Authors: A Uthayakumar, E Panagou, C Martyn-Simmons
Journal: British Journal of Dermatology (2021)

of this neutrophil activity across EB types may unveil novel therapeutic targets that can be exploited to modulate neutrophil function and the wound microenvironment to accelerate healing in EB.
Highlights
Journal: JAMA Pediatrics (2019)

Guideline Adherence for Umbilical Hernia Repair 640Hills-Dunlap and colleagues conducted a cohort study of 25 877 patients from 47 children's hospitals.They found that public insurance, lower income, and female sex are independently associated with the repair of asymptomatic umbilical hernias in children earlier than recommended by current guidelines.These children may be at greater risk of undergoing a repair of umbilical hernias that may spontaneously close with further observation.
The Names of Proprietary Preparations.
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SAGE Analysis Demonstrates Increased Expression of TOSO Contributing to Fas Mediated Resistance in CLL.
Authors: Rodrigo Proto-Siqueira, Rodrigo A. Panepucci, Francisco P. Careta, Edgar G. Rizzatti, Abigail Lee, Andrew Clear, Kelly Morris, Roberto P. Falcão, Marco A. Zago, John G. Gribben
Journal: Blood (2007)
Expression from Second-Generation Feline Immunodeficiency Virus Vectors Is Impaired in Human Hematopoietic Cells
Authors: Mary A. Price, Scott S. Case, Denise A. Carbonaro, Xiao-Jin Yu, Denise Petersen, Kathleen M. Sabo, Michael A. Curran, Barbara C. Engel, Hovanes Margarian, Janis L. Abkowitz, Garry P. Nolan, Donald B. Kohn, Gay M. Crooks
Journal: Molecular Therapy (2002)
Shigellosis in Child Day Care Centers— Lexington-Fayette County, Kentucky, 1991
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Editorial: National Rural Health Week April 4 through 10, 1976
Authors: B. L. Bible
Journal: JAMA (1976)

This editorial is abstracted in large part from an article by Browne that soon will be published in<i>Archives of Neurology</i>. The editorial is intended to alert physicians to the article and to bring their attention to the recent approval of clonazepam (Clonopin) by the Food and Drug Administration (FDA) for marketing in the United States. Clonazepam is a benzodiazepine anticonvulsant structurally related to chlordiazepoxide hydrochloride (Librium) and diazepam (Valium). Browne's article reviews in some detail the drug's effects on the electroencephalogram, and, more importantly, presents the facts known from what has been published about clonazepam. The drug is rapidly absorbed by the oral route and appears to pass quickly from blood to brain. Preliminary results indicate a biological half-life of 22 to 32 hours, and the therapeutic serum concentration is 5 to 50 ng/ml. Major side effects of the drug are drowsiness, ataxia, and behavioral changes. They tend to
Highlights
Authors: Howard Bauchner, Donald Berwick, Phil Fontanarosa
Journal: JAMA (2016)

Diet, Exercise on • VO 2 and QOL in Obese Patients With HFPEF 36 Many patients with heart failure with preserved ejection fraction (HFPEF) are overweight or obese and experience exercise intolerance.In a randomized, attention-controlled, 2 × 2 factorial trial involving 100 obese adults with chronic HFPEF, Kitzman and colleagues found that caloric restriction or aerobic exercise training increased participants' exercise capacity and the eff ects may be additive.Neither intervention had a signifi cant eff ect on quality of life (QOL).In an Editorial, Wenger discusses the potential for lifestyle interventions to improve exercise tolerance among overweight patients with HFPEF.