tbuckley/cabot-search huggingface dataset:
Evaluation of therapeutic efficacy of amantadine in patients with naturally occurring A2 influenza
Authors: Y. Togo
Journal: JAMA (1970)

Amantadine hydrochloride had a chemotherapeutic effect in patients with naturally occurring Asian influenza during the epidemic of 1967 to 1968. In double-blind clinical trials in which 54 men were treated with amantadine and 48 men received placebo capsules, more rapid defervescence and improvement of some symptoms were achieved in the drug-treated patients. The effect was demonstrable when drug therapy was started approximately 20 hours after the patients became ill. The causative virus was recovered at a high rate during the first four days of therapy in both groups which indicated that the drug did not affect virus shedding. Systemic as well as local antibody titer increases which developed in amantadine-treated patients during convalescence were equivalent to those of the placebo-treated patients.
Cyclosporine, methotrexate, and methylprednisolone compared with cyclosporine and methotrexate for the prevention of graft-versus-host disease in bone marrow transplantation from HLA-identical sibling donor: a prospective randomized study
Authors: Tapani Ruutu, Liisa Volin, Terttu Parkkali, Eeva Juvonen, Erkki Elonen
Journal: Blood (2000)
BR-14: A novel ultrasound contrast agent demonstrating redistribution after a single venous injection: Implications for detection of coronary stenosis and myocardial viability Nick G. Fisher, Ranjith A. Jayaweera, Jiang-Pin Bin, Howard Leong-Poi, Tadamichi Sakuma, Sanjiv Kaul. University of Virginia, Charlottesville, VA
Journal: Journal of the American College of Cardiology (2001)
Prothrombin time in liver failure: Time, ratio, activity percentage, or international normalized ratio
Authors: A Robert, O Chazouilleres
Journal: Hepatology (1996)

Prothrombin time (PT) is a universal indicator of liver disease severity. However, variability in thromboplastin reagents leads to large interlaboratory differences in PT results. The aim of this study was to determine whether the use of the international normalized ratio (INR) or other modes of expression might achieve PT standardization in patients with liver failure. PT was measured with seven thromboplastin reagents with different sensitivities in plasmas from 27 patients with miscellaneous chronic and acute liver failure and, as a control population, 29 patients on oral anticoagulation therapy. PT was expressed in seconds, ratio, activity percentage, and INR. In patients with liver failure, only activity percentage expression eliminated variability in PT results obtained with the seven thromboplastins while INR, seconds, and ratio values remained significantly different ( P &lt; .01). In patients on oral anticoagulant therapy, only INR normalized PT results. We conclude that, in patients with liver failure, INR fails to yield a PT expression independent of the thromboplastin used and only activity percentage expression may provide a common international scale of PT reporting.
"EXCESS MORTALITY IN PATIENTS WITH ASTHMA ON LONG-ACTING 2-AGONISTS" J. HASFORD AND J.C. VIRCHOW. EUR RESPIR J 2006; 28: 900-902.
Journal: European Respiratory Journal (2007)

12-mg formulation based on two 12-week studies [15, 16] and a 1-yr study in children aged 5-12 yrs [4].''The authors apologise for this error.
High altitude illness. Disease with protean manifestations
Authors: C. S. Houston
Journal: JAMA (1976)

THE INCREASING incidence of altitude illness is mainly caused by the ease and speed with which large numbers of people are now able to reach previously remote high mountain regions. In a recent article inThe Journal, Kleiner and Nelson<sup>1</sup>stated that "high altitude pulmonary edema... is considered a rare entity in the United States and regarded as more of physiologic interest than clinical importance.... This presumed rarity may be unfounded and may actually represent a rarity in recognition rather than incidence." Pulmonary edema is only one of several manifestations of altitude illness. Despite the increasing frequency with which it is being described, many physicians are unaware of the problem, rarely see patients either in the acute or recovery stage, and are hesitant or unable to give appropriate advice as to future activities of patients who have been afflicted once. There are three major clinical manifestations of altitude illness:
Saving (Internal) Medicine
Authors: Richard L. Neubauer
Journal: Annals of Internal Medicine (2006)

Letters2 May 2006Saving (Internal) MedicineRichard L. Neubauer, MDRichard L. Neubauer, MDFrom Providence Hospital, Anchorage, AK 99508.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-144-9-200605020-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We should not be surprised by the observation that the exodus from careers in general internal medicine may be more rapid than previously recognized (1, 2), and this should be a warning to those interested in the health and welfare of the United States. To me, a practicing generalist, these observations validate what seems apparent in the day-to-day practice of medicine: Physicians and trainees are speaking with their feet by fleeing generalist careers. Ironically, this is occurring at the very time when our country needs more generalists to coordinate the care of the growing elderly population with ...References1. Lipner RS, Bylsma WH, Arnold GK, Fortna GS, Tooker J, Cassel CK. Who is maintaining certification in internal medicine—and why? A national survey 10 years after initial certification. Ann Intern Med. 2006;144:29-36. [PMID: 16389252] LinkGoogle Scholar2. Sox HC. Leaving (internal) medicine [Editorial]. Ann Intern Med. 2006;144:57-8. [PMID: 16389255] LinkGoogle Scholar Author, Article, and Disclosure InformationAuthors: Richard L. Neubauer, MDAffiliations: From Providence Hospital, Anchorage, AK 99508.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoLeaving (Internal) Medicine Harold C. Sox Who Is Maintaining Certification in Internal Medicine—and Why? A National Survey 10 Years after Initial Certification Rebecca S. Lipner , Wayne H. Bylsma , Gerald K. Arnold , Gregory S. Fortna , John Tooker , and Christine K. Cassel Saving (Internal) Medicine Ashok V. Daftary Metrics Cited byHigh-Throughput Isolation of Giant Viruses in Liquid Medium Using Automated Flow Cytometry and Fluorescence StainingHow to approach and treat viral infections in ICU patientsGiant Viruses of Amoebae as Potential Human PathogensReal-Time PCR Systems Targeting Giant Viruses of Amoebae and Their VirophagesFree-living amoebae and their intracellular pathogenic microorganisms: risks for water qualityAmoebal pathogens as emerging causal agents of pneumonia 2 May 2006Volume 144, Issue 9Page: 702KeywordsConflicts of interestElderlyHealth careMotivationSub-specialty care ePublished: 2 May 2006 Issue Published: 2 May 2006 Copyright & PermissionsCopyright © 2006 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Avoiding Low Blood Sugar Levels Restores Diabetic Patients' Ability To Recognize the Warning Symptoms of Low Blood Sugar
Journal: Annals of Internal Medicine (2001)

Summaries for Patients1 May 2001Avoiding Low Blood Sugar Levels Restores Diabetic Patients' Ability To Recognize the Warning Symptoms of Low Blood SugarSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-134-9_Part_1-200105010-00004 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Diabetes is a disease characterized by elevations in blood sugar (glucose). Insulin treatment reduces glucose levels, sometimes below normal levels. Extremely low levels of glucose can cause changes in mental function, seizures, and coma. Diabetic patients can usually sense early warning symptoms of low blood sugar, such as sweating, hunger, tremor, or fast heart rate. These warning signs probably depend on the release of adrenalin-like hormones. Unfortunately, some patients stop developing these warning signs, particularly after many episodes of low blood sugar. These people are more likely to ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Avoidance of Hypoglycemia Restores Hypoglycemia Awareness by Increasing β-Adrenergic Sensitivity in Type 1 Diabetes.” It is in the 1 May 2001 issue of Annals of Internal Medicine (volume 134, pages 729-736). The authors are A Fritsche, N Stefan, H Häring, J Gerich, and M Stumvoll.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAvoidance of Hypoglycemia Restores Hypoglycemia Awareness by Increasing β-Adrenergic Sensitivity in Type 1 Diabetes Andreas Fritsche , Norbert Stefan , Hans Häring , John Gerich , and Michael Stumvoll Avoidance of Hypoglycemia Restores Hypoglycemia Awareness by Increasing β-Adrenergic Sensitivity in Type 1 Diabetes Andreas Fritsche , Norbert Stefan , Hans Häring , John Gerich , and Michael Stumvoll Metrics 1 May 2001Volume 134, Issue 9_Part_1Page: I-1KeywordsBlood sugarComaEpileptic seizuresGlucoseHormonesHypoglycemiaInsulinMental functioningType 1 diabetesVeins ePublished: 1 May 2001 Issue Published: 1 May 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Recurrent parathyroid adenoma. Association with prolonged thiazide administration
Authors: L. Balizet
Journal: JAMA (1973)

A 55-year-old man developed three parathyroid adenomas 11 years after the removal of an equal number of parathyroid adenomas. He had received thiazides for nine years prior to removal of the second set of adenomas. Although the evidence is only circumstantial, it is suggested that prolonged thiazide administration may have induced the recurrence of the adenomas.
Abstract 2810: The Occluded Artery Trial (OAT) Viability Ancillary Study (OAT-NUC): Influence of Infarct Zone Viability on Left Ventricular Remodeling After PCI vs. Medical Therapy Alone
Authors: James E Udelson, Camille A Pearte, Carey D Kimmelstiel, Mariusz Kruk, Anna Teresinska, Bartosz Bychowiec, Jose Antonio Marin-Neto, Thomas Höchtl, Eric A Cohen, Paulo Caramori, Benita Busz-Papiez, Christopher Adlbrecht, Zygmunt P Sadowski, Witold Ruzyllo, Sandy A Forman, Deborah J Kinan, Gervasio A Lamas, Judith S Hochman
Journal: Circulation (2007)

Introduction: OAT recently reported no difference in long-term outcomes between percutaneous intervention (PCI) vs. medical therapy alone (MED) in stable post-MI patients with occluded infarct-related arteries (IRAs). Whether PCI may benefit a subset of patients with relative preservation of infarct zone (IZ) viability is unknown. Hypotheses: IZ viability influences left ventricular (LV) remodeling and PCI patients with viability have less adverse remodeling than comparable MED post-MI patients with an occluded IRA. Methods: Patients were eligible for OAT-NUC based on the main OAT criteria. Enrolled patients underwent a resting nitroglycerin-enhanced 99m-Tc sestamibi SPECT study at baseline prior to OAT randomization and repeated 1 year after randomization. SPECT studies were quantitatively analyzed in a central core lab, blinded to OAT randomization and to sequence. Parameters included LV volumes (for remodeling over time), LV regional and global function, infarct size, and IZ viability. Results: There were 124 patients enrolled in OAT-NUC at 20 international sites. For patients with complete baseline and 1 year information as of May 2007 (n=78), infarct size was 24 ± 16% of the LV (mean ± SD), EF 48 ± 11%, end-diastolic volume 127 ± 52 ml, end-systolic volume 71 ± 46 ml, and sestamibi uptake within the IZ was 43 ± 8% of peak counts. Those with severe reduction in IZ viability (IZ uptake &lt;40% of peak counts, n=25) compared to those with at least moderate preservation of viability (IZ counts &lt;40% of peak counts, n=53) had larger infarct size (p&lt;0.001), larger end-diastolic (p&lt;0.001) and end-systolic (p&lt;0.003) volumes at baseline. Complete data acquisition and analysis of the primary and secondary end point results examining the influence of IZ viability on extent of LV remodeling, and the interaction of IZ viability with extent of remodeling for PCI vs. MED in post-MI patients with occluded IRAs will be available for the entire patient cohort by August 2007. Conclusions: The OAT-NUC ancillary study examines the influence of IZ viability on LV remodeling in post-MI patients with occluded IRAs randomized to PCI vs. medical treatment alone and will provide mechanistic insights into the clinical findings of the main OAT study.
Flame retardant exposure: polybrominated diphenyl ethers in blood from Swedish workers
Authors: A Sjödin, L Hagmar, E Klasson-Wehler, K Kronholm-Diab, E Jakobsson, A Bergman
Journal: Environmental Health Perspectives (1999)

Polybrominated diphenyl ethers (PBDEs) are used as additives in polymers and teiles to prohibit the development offires.Because ofthe production and use of PBDEs, the lipophilic haracteris- tics, and persistence, these compounds have become ubiquitous environmental con aminants.The aim of the present study was to determine potential exposures of PBDE to derks working fill- time at computer screen and persomnnel at an elecnics-disntling plant, with hospitl deaners as a control group.Five PBDE 2',4,2,2',4,4',5,2,2',4,4',5,2,2',3,4,4',5', and decaBDE-were quantified in blood serum from all three categories of workers.Subjects woring at the dismanting plt showed sig- nificantly higher levels of all PBDE congeners in their serum as compared to the control group.Decabromodiphenyl eier is present in concentrations of 5 pmollg lipid weight (1w) in the person- nel dmantling ectronics; these concentratons are comple to the concentrations of2,2',4,4'- tetraBDE.The later compound was the do ting PBDE congener in the derks and deaners.The major compound in personnel at the dismantling plant was 2,2 ',3,4,4t,5', Concentrations of this PBDE congener are almost twice as high as for 2,2',4,4'-tetraBDE in these workers and seventy times the levl ofthis heptaBDE in deaners.The totl median PBDE concen trations in the serum from workers at the electonics-dismanlding plant, derks, and deaners were 37, 7.3, and 5.4 pmollg lw, respectively.The results show that decabromodiphenyl ether is bioavailable and that occupational exposure to PBDEs occurs at the electronics-dismantding plant.IGy work analysis, blood, contamination, DBDE, decabromodiphenyl ether, electronics recycing, flame nts, levels, occupational exposure, PBDE, persistent organic pollutants, polybromi- nated diphenyl ethers.
Agricultural Pesticide Use in California: Pesticide Prioritization, Use Densities, and Population Distributions for a Childhood Cancer Study
Authors: Robert B. Gunier, Martha E. Harnly, Peggy Reynolds, Andrew Hertz, Julie Von Behren
Journal: Environmental Health Perspectives (2001)

Several studies have suggested an association between childhood cancer and pesticide exposure. California leads the nation in agricultural pesticide use. A mandatory reporting system for all agricultural pesticide use in the state provides information on the active ingredient, amount used, and location. We calculated pesticide use density to quantify agricultural pesticide use in California block groups for a childhood cancer study. Pesticides with similar toxicologic properties (probable carcinogens, possible carcinogens, genotoxic compounds, and developmental or reproductive toxicants) were grouped together for this analysis. To prioritize pesticides, we weighted pesticide use by the carcinogenic and exposure potential of each compound. The top-ranking individual pesticides were propargite, methyl bromide, and trifluralin. We used a geographic information system to calculate pesticide use density in pounds per square mile of total land area for all United States census-block groups in the state. Most block groups (77%) averaged less than 1 pound per square mile of use for 1991-1994 for pesticides classified as probable human carcinogens. However, at the high end of use density (> 90th percentile), there were 493 block groups with more than 569 pounds per square mile. Approximately 170,000 children under 15 years of age were living in these block groups in 1990. The distribution of agricultural pesticide use and number of potentially exposed children suggests that pesticide use density would be of value for a study of childhood cancer.
Correction
Journal: BMJ (1965)

We publish below a selection of questions and answers of general interest.Tab. Codein.Co. and Phenacetin Nephropathy Q.-What is the maximum daily dose of tab.codein.co.(N.F.) which can be used in cases of severe pain from chronic arthritis without danger of causing phenacetin nephropathy ?A.-This question cannot be answered with a recommended daily dosage of tab.codein.co.(N.F.) which (would avoid all risk of phenacetin nephropathy.There is little doubt from accumulating evidence in the literature that chronic phenacetin ingestion gives rise to renal damage.Most cases are diagnosed only in the late stages, and most have consumed at least 1 g. of phenacetin daily for several years.It is likely, however, that even relatively small doses of phenacetin given over a long period will give rise to renal damage, possibly with secondary pyelo- nephritis.Kasanen and Salmil found that 85% of
Abstract 1690: Prevention of Contrast-Induced Nephropathy by Carperitide
Authors: Shuji Morikawa, Takahito Sone, Hideyuki Tsuboi, Hiroaki Mukawa, Itsuro Morishima, Michitaka Uesugi, Kensuke Takagi, Toru Niwa, Yusuke Izumi
Journal: Circulation (2007)

Introduction: Contrast-induced nephropathy (CIN) remains as a common complication of angiographic procedure. Carperitide, an antagonist of secretion of rennin, aldosterone and vasopressin with natriuretic effects, has renal protective effects. Hypothesis: Carperitide may be effective in preventing CIN. Methods: We prospectively studied 170 consecutive patients with chronic renal failure (serum creatinine(SCr) concentration &gt;1.3mg/dl)who underwent coronary angiography. The patients were randomly assigned to either 1.3ml/kg/hr of lactated Ringer’s infusion plus carperitide 0.042μg/kg/min (Carperitide group N=86) or lactated Ringer’s infusion alone (Control group N=84). The administration was initiated 6 hours prior to the procedure and continued for 48 hours after angiography. The concentration of SCr and cystatin C were measured at baseline, 24 hours, 48 hours, 1 week, and 1 month following the angiography. Results: The SCr concentration increased gradually up to one month in the Control group, whereas remained almost unchanged in the Carperitide group (p=0.001 for the trend, Figure ). The cystatin C concentration also showed the same trend (p=0.013 for the trend, Figure ). When CIN was defined as an increase of ≥0.5 mg/dl or ≥25% in the SCr at 48 hours after angiography, CIN developed in 7 of 84 patients (8%) in the Control group and 1 of 86 patients (1%) in the Carperitide group (P=0.047). Multivariate analysis disclosed that carperitide infusion (OR 0.097, P=0.041) and quantity of contrast media (OR 14.06, P=0.004) were significantly related to the development of CIN. Conclusions: Carperitide is effective in preventing CIN in patients with chronic renal failure.
Monoblastic leukemia in an HIV‐infected patient: Absence of viral expression in RNA blasts
Authors: C. Guillemain, F. George, M. Courcoul, C. Dhiver, C. Brunet, B. Spire, N. Horschowski, M. Conciatori, J. Sampol
Journal: American Journal of Hematology (1996)

A small number of patients seropositive for the human immunodeficiency virus (HIV) have been reported as developing acute non-lymphoblastic leukemia (ANLL). In the cases previously published, the authors never reported a study of the link joining HIV infection and leukemia. We describe here the case of a 41-year-old HIV positive patient who developed ANLL (FAB classification M5). Using molecular techniques, we looked for a direct link between these two co-existing diseases. We showed the absence of HIV expression in the malignant clone, suggesting that the association of ANLL and Acquired Immune Deficiency Syndrome is not a direct consequence of the myeloid precursors infection. Nevertheless a relationship may exist through a disorganization of the bone marrow micro-environment. © 1996 Wiley-Liss, Inc.
On scleroderma. Mast cells, endothelial cells, and fibroblasts
Authors: H. N. Claman
Journal: JAMA (1989)

An integrated view of the pathogenesis of scleroderma should include vascular, immunologic, and fibrotic processes. This review introduces the mast cell into this picture, emphasizing recent knowledge gained from a study of experimental chronic graft-vs-host disease and scleroderma itself. In both of these situations, increased mast cell activity occurs. A link between the activation of both endothelial cells and fibroblasts may be provided by the family of heparin-binding growth factors. These cytokines are produced by many cells and are bound, protected, and enhanced by heparin, which may be provided by the activated mast cells. These and other growth factors may be responsible for endothelial proliferation and excess collagen production by fibroblasts. This enlarged schema should provide additional points for therapeutic intervention in scleroderma. (<i>JAMA</i>. 1989;262:1206-1209)