tbuckley/cabot-search huggingface dataset:
Morningtown
Authors: Monica Stemmle
Journal: JAMA Pediatrics (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Treatment of Obesity
Authors: Dennis R. Brightwell
Journal: JAMA (1977)

<h3>To the Editor.—</h3> The recent report by Currey et al (237:2829-2831, 1977) on the behavioral treatment of obesity has several shortcomings of which the reader should be aware when making any judgments about it. First, the selection of the three articles presented in tabular form are hardly representative of the nearly 100 research reports published to date. Those presented represent neither the best nor the worst results obtained, nor are the sample sizes particularly representative. The types of treatments used in the three are so different that comparisons are not meaningful. While the selection of papers for review is the prerogative of the author, serious inaccuracies in the discussion of them are unacceptable. When totaling the eight papers reviewed by Stunkard and McLaren-Hume,<sup>1</sup>they apparently omitted completely the data from one of the studies,<sup>2</sup>which reflected some of the best results. The results of Penick et al<sup>3</sup>
A selective defect of interferon alpha production in human immunodeficiency virus-infected monocytes.
Authors: H E Gendelman, R M Friedman, S Joe, L M Baca, J A Turpin, G Dveksler, M S Meltzer, C Dieffenbach
Journal: The Journal of Experimental Medicine (1991)

1433), there were errors in the nucleotide primer and probe sequences presented in Table 1 .The correct sequences of nucleotides
NEPHROTOXINS.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sources of contamination in open heart surgery
Authors: R. M. Kluge
Journal: JAMA (1974)

A prospective study was undertaken to identify potential sources of infection in patients requiring open heart surgery. Preoperative blood and urine cultures were sterile. Cultures done during surgery were positive in 47 (71%) of 66 patients studied. The most common site of microbial contamination was the repaired area of the myocardium and the prosthesis just prior to wound closure; diphtheroids and<i>Staphylococcus epidermidis</i>were the most frequent operative isolants. Postoperative blood cultures were sterile; however, 41% of urinary catheter tips and 50% of intravascular catheter tips yielded a variety of Gram-positive and Gram-negative organisms and fungi. Endocarditis was not encountered despite the high incidence of perioperative contamination by organisms that commonly cause postoperative infective endocarditis. (<i>JAMA</i>230:1415-1418, 1974)
Plasma levels of substance p in liver cirrhosis: Relationship to the activation of vasopressor systems and urinary sodium excretion*1
Authors: C FERNANDEZRODRIGUEZ
Journal: Hepatology (1995)

The mediators of the hyperdynamic circulation of liver cirrhosis are not well characterized. Substance P is a potent vasodilatory peptide produced by the enteric nervous system and partly cleared by the liver. In this work we have investigated the plasma levels of substance P and their relationship to the hemodynamic, neurohormonal, and renal function changes occurring in patients with cirrhosis. Seven healthy subjects (control group), 7 cirrhotic patients without ascites (group I), and 24 cirrhotic patients with ascites (group II) were studied. Cardiac output (CO), femoral blood flow (FBF), blood volume (BV), femoral arteriovenous difference of oxygen content (Ca-v O2), plasma renin activity (PRA), plasma aldosterone concentration (PAC), and plasma norepinephrine (NE) were determined. Five patients underwent trans-jugular intrahepatic porto-systemic stent shunt (TIPSS) because of refractory ascites. Immunoreactive substance P (irSP) was measured by radioimmunoassay after plasma extraction. irSP was higher in ascitic patients than in healthy controls (P < .01) and directly correlated with PRA, PAC, plasma NE, and Pugh's score and was inversely correlated with urinary sodium excretion, glomerular filtration rate, and Ca-v O2. No differences were observed between portal and peripheral vein irSP concentration. TIPSS placement induced a decrease in portal pressure and an increase in CO but circulating irSP remained unchanged. Our data show that circulating irSP is increased in decompensated cirrhotic patients and may be involved in the pathogenesis of the hemodynamic changes of cirrhosis. Alleviation of portal hypertension did not result in decreased plasma levels of this vasodilatory substance.
Members of the House of Delegates
Journal: JAMA (1977)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract P016: Metabolites of Glutamate Metabolism are Associated with Incident Cardiovascular Events in the Predimed (“Prevencion Con Dieta Mediterranea”) Trial
Authors: Yan Zheng, Frank B Hu, Miguel Ruiz-Canela, Clary Clish, Courtney Dennis, Jordi Salas-Salvado, Adela Hruby, Liming Liang, Estefania Toledo, Dolores Corella, Emilio Ros, Montserrat Fitó, Enrique Gómez-Gracia, Fernando Arós, Miquel Fiol, José Lapetra, Lluis Serra-Majem, Ramón Estruch, Miguel A Martínez-González
Journal: Circulation (2016)

Background: Glutamate metabolism may play a role in the pathophysiology of cardiometabolic disorders. However, there is limited evidence on the association between glutamate-related metabolites and, moreover, changes in these metabolites, and risk of cardiovascular disease (CVD). Methods and Results: Plasma levels of glutamate and glutamine were measured at baseline and 1-year follow-up in a case-cohort study including 980 participants (mean age: 67 years; 46% male) from the PREDIMED randomized trial, which assessed a Mediterranean diet intervention in the primary prevention of CVD. During median 4.8 years of follow-up, there were 229 incident CVD events (non-fatal stroke, non-fatal myocardial infarction, or CVD death). In fully-adjusted models, per 1-SD, baseline glutamate was associated with 43% (95% CI: 16-76%) and 81% (39-137%) increased risk of composite CVD and stroke alone, respectively, and baseline glutamine-to-glutamate ratio with 25% (6-40%) and 44% (25-58%) decreased risk of composite CVD and stroke alone, respectively. Associations appeared linear for stroke (both Plinear trend≤0.005). Among participants with high baseline glutamate, the interventions lowered CVD risk by 37% compared to the control diet; the intervention effects were not significant when baseline glutamate was low (Pinteraction=0.02). No significant effect of the intervention on year-1 changes in metabolites was observed, and no effect of changes themselves on CVD risk was apparent. Conclusions: Baseline glutamate was associated with increased CVD risk, particularly stroke, and glutamine-to-glutamate ratio was associated with decreased risk. Participants with high glutamate levels may obtain greater benefits from the Mediterranean diet than those with low levels.
Monitoring Breast Milk Contamination to Detect Hazards from Waste Disposal
Authors: Walter Rogan, Beth Gladen
Journal: Environmental Health Perspectives (1983)

Human milk is a repository for certain classes of long-lived, fat-soluble environmental contaminant chemicals. Some members of this class, such as the chlorinated pesticides and the chlorinated biphenyls, can be expected to be present at chemical waste disposal sites. Analysis of samples of breast milk obtained from women near such a site could provide documentation that exposure has taken place. However, background contamination is present and must be dealt with by the collection of comparison samples. Sample collection can be difficult because of the low level of chemicals being sought, and thus the possibility of sample contamination. The diagnostic and public health consequences of contaminated breast milk are not clear at this time, and thus chemical analysis of milk should be carried out in a research setting. Despite these difficulties, breast milk monitoring has been a successful tool in certain investigations of the spread of environmental chemicals.
The role of granulomatous phlebitis and thrombosis in the pathogenesis of cirrhosis and portal hypertension in sarcoidosis
Authors: F Moreno-Merlo
Journal: Hepatology (1997)

Sarcoidosis often involves the liver with mild elevation of serum enzymes and granulomas histologically. Rarely, chronic cholestasis, portal hypertension, cirrhosis, or nodular hyperplasia may be found. The pathogenesis of the portal hypertension and of the cirrhosis are not understood, in part because large samples of tissue have seldom been described. We describe the clinical and anatomic findings of four patients with sarcoid liver disease in whom the whole livers were available for examination. One patient had cirrhosis, one had diffuse nodular hyperplasia, and two had small regions of parenchymal fibrosis. The first two of these had a history of variceal bleeding and healed portal vein thrombosis. One had chronic cholestasis without cirrhosis. We suggest that the cirrhosis and focal fibrosis were caused by ischemia secondary to primary granulomatous phlebitis of portal and hepatic veins. The portal hypertension in two patients was likely secondary to portal vein thrombosis, because cirrhosis was absent at the onset of variceal bleeding.
Reflection
Authors: Jack Coulehan
Journal: Annals of Internal Medicine (2019)

Ad Libitum5 March 2019ReflectionJack Coulehan, MDJack Coulehan, MDCenter for Medical Humanities, Compassionate Care, and Bioethics at Stony Brook University, Stony Brook, New York (J.C.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M18-2713 Audio Reading - “Reflection” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Reflection," by J. Coulehan. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail I imagine my mother's dementiabegan like this—occasional smudges,blots, that gradually coalesced.Incline suddenly fails to appearwhen I want it. The percentage riseon a treadmill, an old funicular,hides behind a blot that wasn't thereearlier. I pester the blot's edgesby suggesting diagonal, upwards,to no effect. When incline comes back,I've taken the train to anotherlocation. How many times was she blockedbefore the sludge hardened? I once thoughtsubtractions swept her identity awayand left a shell, but now that I've begunto forget on my own, I'm inclinedto believe my mother was silencedby accretion, not loss, and shesurvived as a blessed ... Author, Article, and Disclosure InformationAffiliations: Center for Medical Humanities, Compassionate Care, and Bioethics at Stony Brook University, Stony Brook, New York (J.C.)Current Author Address: Jack Coulehan, MD; e-mail, john.[email protected]edu. PreviousarticleNextarticle Advertisement Audio Reading - “Reflection” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Reflection," by J. Coulehan. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 5 March 2019Volume 170, Issue 5Page: 348KeywordsCell wallsDementiaSludgeStem cells ePublished: 5 March 2019 Issue Published: 5 March 2019 Copyright & PermissionsCopyright © 2019 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Abstract 2499: Sulfasalazine sensitizes glioblastoma cells to radiation treatment
Authors: Linda Sleire, Jian Wang, Jan Heggdal, Paal-Henning Pedersen, Per Øyvind Enger
Journal: Cancer Research (2011)

Abstract Glioblastomas (GBMs) are lethal cancers with a limited response to ionizing radiation. Recent studies suggest that Sulfasalazine (SAS), a drug used to treat inflammatory bowel disease, inhibits the xCT antiporter system in glioma cells, thereby blocking their uptake of cystein. Since the availability of cystein is a rate limiting step in intracellular antioxidant production, we wanted to investigate whether sulfasalazine sensitizes glioma cells to radiation. SAS effect on glioma cell growth was investigated using an electric cell substrate impedance sensing (ECIS) instrument. All cell lines showed altered growth curves in response to SAS treatment. To assess the effect of blocking the xCT antiporter, intracellular levels of the antioxidant glutathione were measured. With increasing doses of SAS, glutathione levels decreased in a dose response manner. Further, U251 glioma cells were treated with escalating doses of SAS, alone or in combination with radiation (8 Gy). Nuclear integrity was evaluated to estimate cell death following treatment. In addition, cell death and viability were investigated using live/dead staining and MTS assay respectively. All treatment groups exhibited increased rates of cell death compared to untreated controls. However, a combination of SAS and radiation resulted in higher levels of cell death, than radiation or SAS administered alone. In order to assess whether this can be exploited therapeutically, we are currently preparing to treat nude rats harbouring gliblastoma biopsy xenografts with SAS, alone or in combination with radiation. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2499. doi:10.1158/1538-7445.AM2011-2499
Abstract 271: Ca <sup>2+</sup> /Calmodulin-Dependent Kinase Kinase β (CaMKKβ) Contributes to AMPK Activation in the Heart during Hypoxia
Authors: Agnes Kim, Ji Li, Jennifer Hu, Arthur M Edelman, Lawrence H Young
Journal: Circulation (2007)

AMP-activated protein kinase (AMPK) is a stress signaling enzyme that regulates important cellular responses to ischemic stress in the heart. AMPK stimulates glucose uptake and utilization during myocardial ischemia and limits cardiac apoptosis and contractile dysfunction associated with ischemia/reperfusion injury. Activation of AMPK involves allosteric regulation by AMP/ATP ratio as well as phosphorylation by upstream AMPK kinases (AMPKKs) including LKB1 and CaMKKβ. The identity of the AMPKKs involved in the activation of AMPK during myocardial ischemia is not fully defined. The aims of this study were to determine whether CaMKKβ is expressed in the heart and in cardiomyocytes CaMKKβ is activated during ischemia and CaMKKβ contributes to AMPK activation during ischemia. CaMKKβ mRNA and protein were found to be expressed in mouse and rat hearts and isolated rat cardiomyocytes. To determine whether myocardial ischemia stimulates CaMKKβ activity in vivo , mouse hearts were subjected to regional ischemia by LAD occlusion, and assessed for phosphorylation of CaMKI (Thr 177 ), a direct downstream substrate of CaMKKβ. There was a 4-fold increase in CaMKI phosphorylation on its activating Thr 177 site within 2–5 min of ischemia (p&lt;0.05 vs. control). CaMKKβ signaling was transiently activated and correlated with the initial rise in AMPK phosphorylation during the early phase of myocardial ischemia. To further determine whether CaMKKβ participates in ischemia-induced heart AMPK activation and glucose uptake, isolated rat left ventricular papillary muscles were subjected to hypoxia in the presence of a specific CaMKKβ inhibitor, STO-609 (2 μM). CaMKKβ inhibition resulted in a 60% reduction in hypoxia-induced AMPK activation (p&lt;0.01 vs. hypoxia). In addition, inhibition of CaMKKβ yielded an 85% and 30% reduction in hypoxia-induced ACC phosphorylation and glucose uptake, respectively (p&lt;0.05 vs. hypoxia), two well-known downstream consequences of AMPK activation. CONCLUSION: Myocardial ischemia leads to an early, transient stimulation of the CaMKKβ pathway which correlates with the initial activation of AMPK during ischemic stress. CaMKKβ partially mediates hypoxia-induced activation of AMPK pathway in the heart.
Abstract 14741: Asian Dust Has an Impact on the Incidence of Acute Myocardial Infarction ~a Time-stratified Case-crossover Study
Authors: Sunao Kojima, Kunihiko Matsui, Kayo Ueda, Hiroshi Nitta, Hisao Ogawa
Journal: Circulation (2014)

Introduction: Air pollution, a mixture of gases and particles that come from manmade and natural sources, has been shown to increase hospi¬tal admission and mortality attributable to cardiovascular diseases. Asian dust (AD), a windblown sand dust originating from mineral soil in the desert, and PM2.5, which comes from cars and trucks, power plants, industrial boilers, other industrial sources and wildfires, are the standard for particulate matter representing air pollution. Hypothesis: We assessed the hypothesis that AD and PM2.5 were associated with the incidence of acute myocardial infarction (AMI) in Kumamoto prefecture. Methods: Kumamoto prefecture is located in southwestern Japan and has a stable population of 1.8 million. A total of 3,670 AMI patients in 2009-2012 in Kumamoto prefecture were entirely registered and 199 AMI patients whose onset date was not definite were excluded in the present study. A time-stratified case-crossover study was conducted to assess the association between particulate matters and AMI incidence. Within-subject comparisons were made between a case and control periods in this design. The study estimated the odds ratios and 95% confidence intervals associated with AMI incidence during the case day to a few previous days using conditional logistic regression. Results: The case-crossover analysis showed that PM2.5 was not significantly associated with the incidence of AMI (Figure upper). However, the results after adjustment for temperature and relative humidity revealed a close association between AD and the incidence of AMI (Figure lower). The strong association was observed on day 1. Adding co-pollutants including oxidants, nitrogen dioxide and sulfur dioxide in the basic model did not substantially alter the results. Conclusions: AD increases the incidence of AMI compared with PM2.5. Attention should be called to patients already at high risk for cardiovascular disease in case of an official announcement of AD warning.
Esophageal tuberculosis: a microgranuloma visualized by narrow-band imaging magnifying endoscopy
Authors: Y. Takaki, K. Yao, Y. Yano, T. Matsui, H. Tanabe, S. Haraoka, A. Iwashita, R. Nakashima
Journal: Endoscopy (2011)

Takaki Y et al. Esophageal tuberculosis: a microgranuloma visualized by narrow-band imaging magnifying endoscopy. Endoscopy 2011; 43: published online 04. 10. 2011
Table of Contents
Authors: Ki Sung, Seungho Ryu, Gerald Reaven, Stig Dyrskog, Mogens Erlandsen, Jianguo Chen, Jing Hong, Reziwanggu Abudula, Kjeld Hermansen, Nadjat Ouslimani, Meriem Mahrouf, Jacqueline Peynet, Dominique Bonnefont-Rousselot, Claudine Cosson, Alain Legrand, Jean-Louis Beaudeux, Mirjam Langeveld, Saskia Scheij, Peter Dubbelhuis, Carla Hollak, Hans Sauerwein, Peter Simons, Johannes Aerts, Kalle Sipilä, Teemu Koivistoinen, Leena Moilanen, Tuomo Nieminen, Antti Reunanen, Antti Jula, Veikko Salomaa, Risto Kaaja, Tiit Kööbi, Katriina Kukkonen-Harjula, Silja Majahalme, Mika Kähönen
Journal: Metabolism (2007)
基底细胞癌的遗传学分析
Authors: M.G.H.C. Reinders, B. Cosgun, L.M.C. Gijezen, C.N. Oosterhoud, N.W.J. Kelleners‐Smeets, E. Vermander, M. Vreeburg, P.M. Steijlen, K. Mosterd, M. Geel
Journal: British Journal of Dermatology (2019)

基底细胞癌(BCC或“蚕食性溃疡”)是最常见的皮肤癌,通常不会播散到身体其他部位。它们在老年人中并不罕见,但一些在早年发生很多 BCC 的患者中存在罕见的遗传性疾病 -基底细胞痣综合征(BCNS 或“Gorlin 综合征”)。BCNS 的其他线索包括面部形状不规则、颌骨囊肿和掌跖部称为掌跖凹点的微小不规则区域。通过检测从血液样本中提取的DNA来确诊。BCNS 是由一种称为PTCH1的基因发生错误(突变)导致的,这一突变通常从父母遗传而来,但偶尔首先在胚胎期发生,在后一种情况下,患者被描述为嵌合体,因为一些体细胞含有此错误,而另一些则没有。嵌合体患者可能难以诊断,因为他们的病情较轻(有时候,在儿童期发生 BCC 是唯一表现),PTCH1突变的血液检查可能为阴性。这篇来自比利时和荷兰的论文描述了两名此类患者:一名只在身体一侧发生 BCC 但无其他 BCNS 特征的 41 岁女性和一名存在 BCC、颌骨囊肿和掌部凹点的 36 岁女性。在这两名患者中,血液检查结果都为阴性,但在所检测的 BCC 中都发现了PTCH1 突变。通过确认此诊断,可以让医生们就可能的 BCNS 并发症和将此病传给下一代的风险为这些患者提供咨询。