tbuckley/cabot-search huggingface dataset:
A phase II multicentric trial of combined chemotherapy with gemcitabine plus S-1 in patients with advanced pancreatic cancer
Authors: S. Ohkawa, A. Amano, M. Ueno, K. Miyakawa, K. Sugimori, K. Tanaka, M. Kida
Journal: Journal of Clinical Oncology (2007)

15129 Background: While gemcitabine (GEM) is the standard drug for chemotherapy against advanced pancreatic cancer, the development of multidrug therapies for improved outcome is important. We conducted multicentric combined chemotherapy with GEM and S-1 trial and reported the results of the phase I trial last year. And this phase II study evaluated the efficacy and feasibility. Methods: The subjects had unresectable pancreatic ductal cancer. Eligibility criteria were pathologically-proven, Karnofsky performance status 80 to 100%, age 20 to 74 years, adequate hematological, renal, and liver functions and written informed consent. The method of administration was single administration of GEM on the first day of the week 1000 mg/m 2 , with concurrent administration of S-1 at 80 (&lt;1.5 m 2 ) to 100 (=1.5 m 2 ) mg/day × 7 days, repeated every other week until the progressive disease or life threatening adverse events. This administration dose was determined from the result of the phase I study. The primary endpoint was median survival time. And the secondary endpoints were the overall response rate and the toxicities. Results: 40 patients(pts) were enrolled. Average age was 62.9±8.3 years (34–73 years). Thirty nine pts were conducted this therapy except one who refused this study before the start of administration. Thirty eight pts were evaluable for response, partial response, stable disease, progressive disease were observed in 7 (17.5%), 21 (52.5%) and 10 pts (25.0%), respectively. The median survival time at this stage is 276±51 days in this ongoing study. Grade 3 and 4 toxicities were mainly leucocytes(10 pts), neutrophils(8 pts) and anorexia(6 pts). Conclusions: The GEM plus S-1 combined chemotherapy is effective and feasible in patients with advanced pancreatic cancer. No significant financial relationships to disclose.
Chronic Daily Headache
Authors: Michele Saunders
Journal: New England Journal of Medicine (2006)

Chemoprevention is important in a field in which multiple primary tumors may occur in the same patient, but advances appear disappointing, and a change in lifestyle is still the greatest contributor to the long-term survival of the patient with head and neck cancer who is cured of the presenting tumor.The chapter on gene therapy is satisfactorily comprehensive, but because the field is complex, the chapter would have benefited from the addition of a simple summary of the important points.Certainly, this book will be a valuable tool for surgeons and oncologists who deal with head and neck cancer.It would also be a useful addition to any institution's library.
Arteriovenous Shunt
Authors: T. J. Buselmeier
Journal: JAMA (1978)

<h3>To the Editor.—</h3> I read with interest the article entitled "Conversion of External Arteriovenous Hemodialysis Shunt to Internal Fistula" (239:1782, 1978). We, too, have had good experience with the conversion of the arterialized high-flow system of a prosthetic arteriovenous shunt to a fistula. We have found that the fistulas could be used immediately after conversion, because the vein had already developed in that its wall had thickened and sufficient dilation had occurred approximately three to five weeks after the initial insertion of the arteriovenous shunt. The Figure shows our technique.<sup>1-3</sup>
Congenital Aneurysm of Left Aortic Sinus: Rare Lesion and Rare Cause of Coronary Insufficiency
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
E-cadherin is involved in the intrahepatic metastasis of hepatocellular carcinoma
Authors: T Osada, M Sakamoto, Y Ino, A Iwamatsu, Y Matsuno, T Muto, S Hirohashi
Journal: Hepatology (1996)

In human hepatocellular carcinoma (HCC), the liver is the major target organ of metastasis, which is known as intrahepatic metastasis. To analyze the mechanism of this metastasis, we established two sublines from the human HCC cell line Li7. Subline Li7HM produced multiple liver metastasis, whereas subline Li7NM never did so after intrasplenic injection into nude mice. Two–dimensional gel electrophoresis and immunoblot analysis showed that only Li7NM expressed vimentin and lacked E–cadherin expression, indicating that this clone had undergone epithelial–mesenchymal transition. We then transfected mouse E–cadherin complementary DNA into Li7NM cells and found that the transfectant cells (EM16.21B.3) formed liver metastasis (8/16 mice) after intrasplenic injection and liver tumors (11/13 mice) after intrahepatic injection, whereas the control cell line formed no tumors. These results suggest that E–cadherin plays an important role in the process of intrahepatic metastasis of HCC.
Asbestos content in lungs of occupationally and nonoccupationally exposed individuals
Authors: R. F. Dodson
Journal: JAMA (1984)

Previous reports have indicated that a majority of the population has asbestos bodies within their lungs. These studies generally have been carried out using cohorts from urban environments. The present study compares the asbestos body levels from three unique cohorts: (1) a nonoccupationally exposed group from a large urban environment having a relatively low asbestos content, (2) patients with lung cancer from a nonurban setting, and (3) amosite asbestos workers, who worked and lived in a rural setting. The number of asbestos bodies in both the urban nonoccupationally exposed group and the patients with lung cancer was generally found to be low or below limits of detectability, with the exceptions being those persons in whom an occupational exposure was eventually found. The ferruginous body content of the occupationally exposed group varied considerably between individuals as well as between sites within the same individual. (<i>JAMA</i>1984;252:68-71)
Not there yet, but 'on our way' in AIDS research, scientists say
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
JAPAN
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A CASE OF URETHRAL CALCULUS OF FIFTY-THREE YEARS' DURATION
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Histamine and glucagon tests in diagnosis of pheochromocytoma
Authors: S. G. Sheps
Journal: JAMA (1968)

The glucagon hydrochloride test of Lawrence was compared with the standard cold pressor-histamine test in 12 patients with pheochromocytoma and in 35 control patients without tumor. Urinary and blood catecholamine levels and the values for urinary vanilmandelic acid and total metanephrine were also determined. One patient without a tumor had a pressor response after receiving histamine; none had a pressor response after receiving glucagon. Eleven patients with tumor were given 1 mg of glucagon; six had a positive pressor response, and four of these six had a positive response after receiving histamine as well. One patient with tumor responded positively to histamine but not to 0.5 mg of glucagon. Although determination of the level of urinary metanephrine remains the preferred screening test for pheochromocytoma, when adjunctive studies are desired we recommend the cold pressor-glucagon test (1 mg) instead of histamine as the standard provocative pharmacologic test for pheochromocytoma.
The Cover
Authors: Marsha Meyer
Journal: JAMA (1985)

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FIBRINOLYTIC STREPTOCOCCI
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Obituaries
Journal: JAMA (1976)

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Garbled Title
Journal: JAMA (1977)

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Asbestos, Asbestosis, and Lung Cancer: Observations in Quebec Chrysotile Workers
Authors: Bruce W. Case, Andre Dufresne
Journal: Environmental Health Perspectives (1997)

One prospective epidemiologic study of asbestos cement workers with radiological small opacities has been cited as a rationale for attributing excess lung cancer to asbestosis.This approach could have considerable practical value for disease attribution in an era of decreasing exposure.However, a recent International Agency for Research on Cancer review concludes that the mechanisms of production of asbestos-related lung cancer are unknown.Asbestosis, therefore, cannot be a biologically effective dose marker of lung cancer susceptibility.Asbestosis nonetheless would be useful in identifying asbestos-attributable lung cancer cases if it could be proven an infallible exposure indicator.In this study, we tested this hypothesis in the chrysotile miners and millers of Quebec, Canada.We examined exposure histories, autopsy records, and lung fiber content for 111 Quebec chrysotile miners and millers.If the hypothesis of an asbestosis requirement for lung cancer attribution were accurate, we would expect an asbestosis diagnosis to separate those with lung cancer and high levels of exposure from those with lower levels of exposure in a specific and sensitive manner.This is the first such study in which historical job-based individual estimates based on environmental measurements, lung fiber content, exposure timing, and complete pathology records including autopsies were available for review.We found significant excesses of lung tremolite and chrysotile and estimated cumulative exposure in those with lung cancer and asbestosis compared to those with lung cancer without asbestosis.However, when the latter were directly compared on a case-by-case basis, there was a marked overlap between lung cancer cases with and without asbestosis regardless of the measure of exposure.Smoking habits did not differ between lung cancer cases with and without asbestosis.In regression models, smoking pack-years discriminated between those with and without lung cancer, regardless of asbestosis status.Most seriously, the pathologic diagnosis of asbestosis itself seemed arbitrary in many cases.We conclude that although the presence of pathologically diagnosed asbestosis is a useful marker of exposure, the absence of this disease must be regarded as one of many factors in determining individual exposure status and disease causation.
Paracrine interaction between hepatocytes and macrophages after extrathyroidal proteolysis of thyroglobulin.
Authors: K Brix
Journal: Hepatology (1997)

Thyroglobulin (Tg), the precursor of the thyroid hormones triiodothyronine (T3) and thyroxine (T4), is known to derive from thyroid epithelial cells. Part of Tg reaches the circulation as an intact molecule by transcytosis across the epithelial wall of thyroid follicles. Circulating Tg is a potential ligand for the asialoglycoprotein receptor of hepatocytes. In this report we show, however, that clearance of circulating Tg occurred exclusively by endocytosis in liver macrophages, whereas hepatocytes did not participate in this process. The biological significance of this Tg uptake by the macrophages might consist in an increase of thyroid hormones in close proximity to the macrophages, thereby affecting the hepatocyte metabolism. To test this hypothesis, co-cultures of hepatocytes and macrophages were incubated with Tg, which resulted in the release of thyroid hormones and in a significant increase in the activity of lipogenesis and of hepatocellular key enzymes of the hexose monophosphate shunt. This effect of Tg could be mimicked by equivalent amounts of T3 or T4 exclusively in the co-cultures. When hepatocytes were incubated with thyroid hormones in the absence of macrophages, no or only little effect was observed, indicating that the interaction of macrophages and hepatocytes was a prerequisite for the stimulation of the hepatocellular metabolism. We conclude that the paracrine effect on HepG2 cells results from the degradation of Tg in J774 cells. Apparently, this process is not confined to the release of thyroid hormones, but it requires the interaction of both cell types, possibly mediated by an additional, as yet unknown stimulus. (Hepatology 1997 Nov;26(5):1232-40)
Roses
Authors: M. Therese Southgate
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal