tbuckley/cabot-search huggingface dataset:
Skiing Injuries
Authors: Arthur E. Ellison
Journal: JAMA (1973)

Precisely one decade ago my associates and I wrote in<i>Public Health Reports</i>, "Skiing is one of the most rapidly growing participant sports in the world, and the rising numbers of injured skiers has become a concern both to the medical profession and to the skiing industry itself."<sup>1</sup>Unfortunately, little has changed. Growth has slowed a bit, but even the present rate added far more skiers to the ranks in 1971-1972 than in 1961-1962. Similarly, we can theorize an injury rate of 0.45% this season, and although this is an improvement over the 0.59% of 1961-1962, there is little to rejoice about. The population at risk has roughly doubled—from 2.5 million to 5 million skiers—and the number injured has increased —from approximately 150,000 to 225,000 a year. The only significant change may be in the degree of current "concern" evidenced by the profession, and particularly the industry, toward the
Erythroid Precursors from Patients with ‘Low Risk’ Myelodysplasia Demonstrate Ultrastructural Features of Autophagy.
Authors: Ewout J. Houwerzijl, Henk-Willem Pol, Nel R. Blom, Ietse Stokroos, Johannes J.L. van der Want, Joost De Wolf, Edo Vellenga
Journal: Blood (2006)
AMA policy: covenants not to compete are unethical for physicians in training. Council on Ethical and Judicial Affairs, American Medical Association
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Amer J Obstetrics &amp;amp; Gynecology, St. Louis
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
In This Issue
Journal: Journal of Clinical Investigation (2011)

IL-2 could help overcome WASp defectsWiskott-Aldrich syndrome (WAS) is an immunodeficiency syndrome marked by susceptibility to infection, bleeding, and dermatitis.The causative gene encodes for WAS protein (WASp), which is expressed in hematopoietic cells and is known to be involved in controlling actin dynamics.WAS patients are susceptible to blood cancers and to infection with herpesviruses; both of these features suggest that the NK cells of the immune system may be dysfunctional in this disease.However, it has previously been shown that when NK cells are isolated from WAS patients and put into culture, they regain their cytotoxicity.New insight into this phenomenon has now been provided by Orange, Roy-Ghanta, Pandey, and colleagues, who describe that a cytokine in the culture medium - IL-2 - is responsible for restoring the cytotoxicity of NK cells from WAS patients (1535-1548).They found that IL-2 induces the expression of a protein related to WASp called WAVE2, which can function in the absence of WASp to control cytoskeletal changes.In addition, the researchers found that administration of IL-2 improved NK cell function in a WAS patient, suggesting that this molecule might be a viable therapeutic for this disease.
Mayo Clinic Proceedings, Rochester, Minn
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Randomized phase III study of gemcitabine plus S-1 combination therapy versus gemcitabine plus cisplatin combination therapy in advanced biliary tract cancer: A Japan Clinical Oncology Group study (JCOG1113, FUGA-BT).
Authors: Makoto Ueno, Chigusa Morizane, Takuji Okusaka, Junki Mizusawa, Hiroshi Katayama, Masafumi Ikeda, Masato Ozaka, Kazuya Sugimori, Akira Fukutomi, Hiroki Hara, Nobumasa Mizuno, Hiroaki Yanagimoto, Keiji Sano, Kazutoshi Tobimatsu, Kei Yane, Shoji Nakamori, Naohiro Sata, Seigo Yukisawa, Hiroshi Ishii, Junji Furuse
Journal: Journal of Clinical Oncology (2018)

4014 Background: Gemcitabine (GEM) plus cisplatin (GC) is the standard of care for advanced biliary tract cancer (BTC). However, GC is considered to be toxic because of nausea, vomiting, and appetite loss, and inconvenient due to requiring hydration before and after administration. GEM plus S-1 (GS) was reported to be promising with preferable efficacy and acceptable toxicity profile. This phase III study aimed to confirm the non-inferiority of GS to GC in terms of overall survival (OS). Methods: Eligibility criteria included chemotherapy-naïve patients with recurrent or unresectable biliary tract adenocarcinoma (gallbladder, intrahepatic biliary tract, extrahepatic biliary tract, or ampulla of Vater), an ECOG-PS of 0–1, and adequate organ function. In the GC arm, 1 g/m2 of GEM and 25 mg/m2 of cisplatin was infused on days 1 and 8 of a 21-day cycle. In the GS arm, 1 g/m2 of GEM was infused on days 1 and 8, and S-1 60, 80, or 100 mg/day according to body-surface area was administered from days 1 to 14 of a 21-day cycle. The primary endpoint was OS and the secondary endpoints included progression-free survival (PFS), response rate (RR), adverse events (AEs), clinically relevant AEs predefined as any of grade 2 or more fatigue, appetite loss, nausea, vomiting, oral mucositis, and diarrhea. The sample size was calculated to be 350 with a one-sided alpha of 5%, a power of 80%, non-inferiority margin of 1.155 in terms of hazard ratio (HR). Results: From May 2013 to March 2016, 354 patients were enrolled. The non-inferiority of GS to GC was demonstrated (median OS: 13.4 months (m) in GC and 15.1 m in GS, HR 0.95; 90% confidence interval (CI), 0.78 to 1.15; P = 0.046 for non-inferiority). Median PFS was 5.8 m in GC and 6.8 m in GS (HR 0.86, 95% CI, 0.70-1.07). RR was 32.4% in GC and 29.8% in GS. Both treatments were generally well tolerated. Clinically relevant AEs were observed 35.1% in GC and 29.9 % in GS. Conclusions: GS demonstrated non-inferiority to GC in OS with good tolerability and was considered as new convenient option of standard of care without hydration for advanced BTC. Clinical trial information: UMIN000010667.
Manual of Roentgenology. Röntgenologisches Hilfsbuch. Eine Sammlung von Aufsätzen über die Grundlagen und die wichtigsten Hilfsmethoden des Röntgenverfahrens. Mit einem Anhang über Radiokivitat. Mit 33 Abbildungen. Ingenieur Friedrich Dessauer.
Journal: JAMA (1905)

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Ocular findings in botulism type B
Authors: W. Terranova
Journal: JAMA (1979)

In April 1977, fifty-nine persons became ill with type B botulism in a large, common-source outbreak. A combination of signs and symptoms that should make the clinician strongly suspect botulism was derived from the histories and ocular findings of these persons. Certain signs of third cranial nerve dysfunction reliably predicted in which patients ventilatory insufficiency would develop. (<i>JAMA</i>241:475-477, 1979)
Flucytosine
Authors: JOHN E. BENNETT
Journal: Annals of Internal Medicine (1977)

Flucytosine is a systemic antifungal drug that is readily absorbed from the gastrointestinal tract. The most clearly documented therapeutic effect has been in cryptococcosis, candidiasis, and chromomycosis. An important limitation of the use of flucytosine in all three diseases has been drug resistance arising during therapy. The addition of low-dose, intravenous amphotericin B to flucytosine therapy of cryptococcosis has appeared to decrease the frequency of secondary flucytosine resistance. In addition, the two drugs have an additive or slightly synergistic effect against flucytosine susceptible isolates of Cryptococcus and Candida. The combination is probably the treatment of choice in cryptococcal meningitis and offers promise in the therapy of systemic candidiasis and nonmeningeal cryptococcosis.
Influence of arrhythmogenic right ventricular dysplasia on the function of intravenous implantable cardioverter defibrillator leads Emilio Garcia-Moran, Mihaela Grecu, Alejandro Cuesta, Jos� Rub�n, Augusto Ord�nez, Guillermo Mora, Lluis Mont, Joseph Brugada. Hospital Cl�nic, Barcelona, Spain
Journal: Journal of the American College of Cardiology (2001)
Syringomyelia. Loss of deep-pain sensation with otherwise normal sensory perception
Authors: K. R. Magee
Journal: JAMA (1967)

SYRINGOMYELIA in the cervical region of the spinal cord usually is not difficult to diagnose. "Dissociated" sensory loss is characteristic; the term refers to loss of pain and temperature perception over the distribution of several dermatomes, with preservation of touch and other forms of sensory perception in these areas. Atrophy of muscles of the upper extremities, distal and often asymmetric, usually accompanies the syndrome. Brisk reflexes in the lower extremities are often present, but at the time the physician is consulted, subjective or objective evidence of dysfunction in the lower extremities usually is minimal. Except for differentiation from an intramedullary tumor during early months of the disease, cervical syringomyelia is not easily confused with other lesions of the spinal cord. Occasionally, however, the typical sensory pattern of syringomyelia is not apparent, and in such cases the neurologic signs may be misleading. This report describes a case of cervical syringomyelia in
John Peter Mettauer (1787-1875)
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Liver
Authors: Ana Powell-Kecxr, J Mauk, * Fawcett, H Binaham, Sai Prmce
Journal: Gut (1992)

Provision of adequate nitrogen in parenteral feeds de- pends upon measurement of 24 hour urinary urea (N) excre- tion.Accurate urine collection is difficult clinically.PABA is quantitatively excreted in urine and given orally is advocated for checking the completeness of urine collec- tions.We examined the feasibility-of adding a known amount of PABA to parenteral feeds and using the ratios of urine concentrations of urea to PABA in spot samples to estimate 24 hour urinary urea excretion.6 patients (4 males) were studied.200mg PABA were added to their routine "3 in 1"
Principles of Orthopedic Surgery
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Infectious medical wastes. Council on Scientific Affairs
Journal: JAMA (1989)

A number of recent incidents involving improper handling and disposal of hospital waste have prompted the demand for more stringent legislation to cover the management of infectious hospital waste. Resolution 53 (December 1987 Interim Meeting) called for the American Medical Association to promote the passage of federal legislation for the proper disposal of infectious hospital waste. This resolution has prompted a Council on Scientific Affairs report on the current status of infectious hospital waste management and of state and federal regulations to control such waste. The Council has concluded that existing federal and state regulations for the management of hazardous waste--in conjunction with the accreditation program of the Joint Commission on Accreditation of Healthcare Organizations and the guidelines of the Environmental Protection Agency and the Centers for Disease Control, if adhered to and properly enforced--should be adequate to ensure that the public and environment are not endangered. Therefore, the Council does not favor additional federal legislation at this time and recommends that this report be accepted in lieu of Resolution 53.
Intratumoral EpCAM-positive cancer stem cell heterogeneity in patients with hepatocellular carcinoma and its impact on clinical outcome
Authors: Jenny Krause, Johann von Felden, Christian Casar, Thorben Fruendt, Johanna Galaski, Caroline Jung, Harald Ittrich, Sören Alexander Weidemann, Till Krech, Asmus Heumann, Jun Li, L Fischer, Ansgar W. Lohse, Henning Wege, Kornelius Schulze
Journal: Journal of Hepatology (2020)
Drug Use in the Nursing Home
Authors: Jerry Avorn
Journal: Annals of Internal Medicine (1996)

Letters15 March 1996Drug Use in the Nursing HomeJerry Avorn, MD and Jerry H. Gurwitz, MDJerry Avorn, MDBrigham and Women's Hospital; Boston, MA 02115Search for more papers by this author and Jerry H. Gurwitz, MDBrigham and Women's Hospital; Boston, MA 02115Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-124-6-199603150-00026 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Drs. Tolle and Bascom raise some important points, with which we generally agree. We have no reason to believe that Alzheimer disease reduces the pain of osteoarthritis, spinal stenosis, or any other condition in the elderly, and it certainly can increase the likelihood of several pain-producing conditions ranging from fecal impaction and urinary retention to decubitus ulcers. Furthermore, just as dementia does not blunt pain, sedatives and tranquilizers do not adequately treat pain. Closer attention to the underlying cause of “agitation” in the elderly often reveals that its cause is untreated pain, for which an analgesic is likely ... Author, Article, and Disclosure InformationAuthors: Jerry Avorn, MD; Jerry H. Gurwitz, MDAffiliations: Brigham and Women's Hospital; Boston, MA 02115 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 March 1996Volume 124, Issue 6Page: 616KeywordsAnalgesicsAntipsychoticsDrugsElderlyNursing homesOpioidsOsteoarthritisSedativesStenosisUlcers ePublished: 15 August 2000 Issue Published: 15 March 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
In Response
Authors: Mahboobeh Safaeian, Mark Schiffman, Julia Gage, Philip E. Castle, Diane Solomon, Cosette M. Wheeler
Journal: Cancer Research (2010)

We thank Drs. Kruse and Slangen for their comments and request for additional data about our recent findings that timing of diagnosis of HPV18/45-related CIN3+ is delayed in comparison with HPV16-associated CIN3+ (1). They suggest that HPV18/45-related lesions might be detected later compared with HPV16-related lesions because acetowhite lesions due to HPV18/45 may be located higher in the endocervix and thus out of the reach of visual evaluation and conventional cytologic evaluation.Unfortunately, we did not capture the location of CIN lesions within the LEEP specimen in ALTS. However, we were able to use data from a previously published analysis in ALTS of the diagnostic utility of endocervical curettage (ECC) among women who had biopsy and ECC performed at colposcopy and were diagnosed with CIN2+ throughout the study (2). When we reanalyzed those data stratified by HPV16 versus HPV18/45 to evaluate whether there was a difference in the proportion of ECC positivity, there was no significant difference in percent ECC positivity for HPV16 CIN2+ (23 of 153 or 15%) compared with percent ECC positivity for HPV18/45 CIN2+ (7 of 64 or 11%), as shown in Table 1. Stratification on whether the paired biopsy showed CIN2+ did not alter the conclusions; moreover, the same patterns were seen when we examined the more stringent disease end point of CIN3+.It is important to mention that ALTS was not designed to address this question specifically. In ALTS, ECCs were done at the discretion of the clinician and thus performed on a small, nonrandom percentage of approximately 18.5% of colposcopy procedures (2). As a consequence, the sample size was small and not sufficiently powered to evaluate the issue raised by Drs. Kruse and Slangen. Therefore, we cannot rule out the possibility that HPV18/45 lesions may be harder to detect because of an endocervical location compared with HPV16 lesions. We agree with Drs. Kruse and Slangen that this is a clinically important question that needs to be addressed in future studies.No potential conflicts of interest were disclosed.Grant Support: National Cancer Institute, NIH, Department of Health and Human Services contract nos. CN-55153, CN-55154, CN-55155, CN-55156, CN-55157, CN-55158, CN-55159, and CN-55105. Some of the equipment and supplies were donated or provided at reduced costs by Digene Corporation (Gaithersburg, MD), Cytyc Corporation (Fenton, MO), Denvu (Tucson, AZ), Roche Molecular Systems (Alameda, CA), and TriPath Imaging, Inc. (Burlington, NC).The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
Intrathecal gentamicin for refractory gram-positive meningitis
Authors: R. D. Shuman
Journal: JAMA (1978)

The mortality for meningitis due to<i>Staphylococcus aureus or Listeria monocytogenes</i>remains high, ranging from 32% to 77%. We treated a patient with staphylococcal meningitis refractory to methicillin sodium and oxacillin sodium, and a patient with<i>Listeria</i>meningitis refractory to penicillin G potassium and ampicillin sodium; both patients were cured when intrathecal gentamicin sulfate was added to the regimen. The combination of intrathecal gentamicin and a penicillin may be beneficial in refractory staphylococcal or<i>Listeria</i>meningitis. (<i>JAMA</i>240:469-471, 1978)
Black-White Disparities in Health Care
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal