tbuckley/cabot-search huggingface dataset:
Recoverable Paraplegia
Authors: Paul C. Bucy
Journal: JAMA (1963)

Most patients with paralysis of the legs due to neoplastic compression of the spinal cord have a favorable outlook. Certain factors indicate a poor prognosis: (1) rapid onset; (2) prolonged paralysis; (3) flaccid paraplegia; (4) paraplegia due to malignant disease; and (5) paralysis associated with vertebral collapse. With early accurate diagnosis, prompt laminectomy and decompression of the spinal cord, and such adjunct therapy as is indicated, the outlook can be improved for many patients. Rapidly developing paraplegia due to neoplastic compression is a neurosurgical emergency. Patients with paraplegia of 2 months or even 18 months duration may recover after surgical decompression. Flaccid paraplegia, although very serious, is not necessarily hopeless. Primary intraspinal lymphosarcoma often has a favorable outlook. Giant-cell tumor of the spine is not malignant and can be cured by surgical decompression and x-ray therapy.
Anti-Leukemia Efficacy and Mechanisms of Action of SL-101, a Novel Anti-CD123 Antibody-Conjugate in Acute Myeloid Leukemia
Authors: Lina Han, Eric Rowinsky, Christopher Brooks, Tomasz Zal, M. Anna Zal, Jared K Burks, Jin Zhou, Stefan O. Ciurea, Gheath Alatrash, Jorge E. Cortes, Hagop M. Kantarjian, Michael Andreeff, Farhad Ravandi, Marina Konopleva
Journal: Blood (2014)
Massachusetts Department of Mental Health
Authors: Warren T. Vaughan, Malcolm J. Farrell
Journal: New England Journal of Medicine (1955)

COMMUNITY PROGRAM FOR MENTALLY RETARDED SCHOOL CHILDREN IN MASSACHUSETTSIn 1952 the Massachusetts Legislature recognized the need for providing additional facilities for retarded children including the more severely handicapped. A special commission was directed to study the number of retarded children in the Commonwealth and the training facilities available for their instruction. It was also ordered to report to the General Court the results of its investigation with recommendations, together with drafts of legislation necessary to carry out such recommendations. This unpaid special commission consisted of a member of the Senate, a member of the House of Representatives, a representative . . .
ABC of hypertension: Blood pressure measurement
Authors: G. Beevers
Journal: BMJ (2001)

<h3>Background</h3> Signal transducer and activator of transcription factor 3 (STAT3) is commonly activated in acute myeloid leukemia (AML) and known for supporting cancer cell proliferation and survival. Recently, we demonstrated that STAT3 also plays a critical role ensuring AML immune evasion. Intravenous injections of bi-functional decoy oligodeoxyribonucleotides (CpG-STAT3dODN) blocked STAT3 activity and induced TLR9 signaling in Cbfb/MYH11/Mpl (CMM) AML cells, thereby resulting in immunogenic effects and T cell-mediated immune responses and leukemia regression. <h3>Methods</h3> To understand the molecular mechanisms of the CpG-STAT3 decoy-induced AML differentiation and immunogenicity, we performed global gene expression analysis on the in vivo treated AML cells using oligonucleotide strategy as well as an inducible STAT3 gene silencing. <h3>Results</h3> Transcriptional profiling revealed the upregulation of myeloid cell differentiation related genes, such as Irf8, Cebpa, and Gadd45A with reduction of oncogenic Runx1 and Run1t1 in CMM leukemic cells after CpG-STAT3dODN but not after control treatments. CpG-STAT3dODN treatment also upregulated set of antigen-presentation related genes, such as CIIta, Il12a, and Ifng in CMM AML cells. Importantly, the induction of Irf8 and Cebpa, with the concomitant suppression of Runx1 were found specifically in the subset of differentiated CD11b+ CMM cells but not in the bulk CD11b– leukemic cells. These effects were likely related to epigenetic reprogramming of AML cells as indicated by treatment-induced changes in the expression and protein levels of STAT3 regulated DNA methyltransferases, DNMT1 and DNMT3a/b. Furthermore, our initial studies suggest that STAT3 inhibition/TLR9 activation leads to immunogenic effects also in a xenotransplanted model of human FLT3-ITD MV4-11 leukemia in humanized mice. CpG-STAT3dODN alone or together with clinically-relevant demethylating agent (Decitabine) triggered differentiation of MV4-11 cells into CD11b+HLA-DR+CD86+ antigen-presenting cells (APCs) and increased ratio of CD8+ to regulatory T cells in the bone marrow, thereby reducing leukemia burden. <h3>Conclusions</h3> Our results suggest that eliminating STAT3 permits the TLR9-driven reprogramming of AML cells into APCs to unleash T cell-mediated responses against leukemia.
Highlights
Journal: JAMA (2017)

The Focused Assessment With Sonography for Trauma (FAST) examination can decrease the use of hospital resources, but it is not routinely used in the evaluation of injured children.Holmes and colleagues conducted a randomized clinical trial of 925 children and adolescents with blunt torso trauma and found that the FAST examination compared with usual care did not improve resource use, emergency department length of stay, safety, or hospital charges.In an Editorial, Kessler considers the challenges of adopting point-of care ultrasound in emergency departments and recommends further study of the FAST examination to reduce exposure to ionizing radiation.
An unresolved problem for developing countries. Korea as exhibit A
Authors: P. S. Crane
Journal: JAMA (1969)

According to Sir William Osler, "to look back except on rare occasions for stock-taking, is to risk the fate of Lot's wife."<sup>1</sup>This may be one of those "rare occasions," which should not come more often than every 25 years or so, to take stock of what we are and have been doing since that wartime graduation in 1944. Today we may be forgiven if we pause to reassess the roles we have played in this exciting battlefield of medicine. The then newly liberated South Korea, where I had grown up, was the locale to which I went to practice. I went armed with a firm belief in the Hopkins-pioneered concept of raising medical standards by applying the pyramid system of internresidency postgraduate training with graduated responsibility. In Korea we were able to apply these concepts of medical education, and saw them take root and develop with amazing speed,
Toxic Puffer Fish Species Illegally Imported to United States
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Catnip and the alteration of consciousness
Authors: B. Jackson
Journal: JAMA (1969)

It has been found that<i>Nepeta cataria</i>(catnip) is now being used for its psychedelic effects. No previous mention of the psychopharmacological effects of this drug have been found in the literature. Patients who had been using cataria regularly, experienced effects very similar to those produced by marihuana.
Allan Mahoney
Authors: M. Sprott
Journal: BMJ (2013)

<h3>ABSTRACT</h3> Visual neuroscientists have long characterized attention as inducing a scaling or additive effect on fixed parametric functions describing neural responses (e.g., contrast response functions). Here, we instead propose that top-down effects are more complex and manifest in ways that depend not only on attention but also other cognitive processes involved in executing a task. To substantiate this theory, we analyze fMRI responses in human ventral temporal cortex (VTC) in a study where stimulus eccentricity and cognitive task are varied. We find that as stimuli are presented farther into the periphery, bottom-up stimulus-driven responses decline but top-down attentional enhancement increases substantially. This disproportionate enhancement of weak responses cannot be easily explained by conventional models of attention. Furthermore, we find that attentional effects depend on the specific cognitive task performed by the subject, indicating the influence of additional cognitive processes other than attention (e.g., decision-making). The effects we observe replicate in an independent experiment from the same study, and also generalize to a separate study involving different stimulus manipulations (contrast and phase coherence). Our results suggest that a quantitative understanding of top-down modulation requires more nuanced and more precise characterization of multiple cognitive factors involved in completing a perceptual task.
Superintendent of Health of Providence, R. I.
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Intra-arterial hepatic chemotherapy combined with systemic infusion of 5-FU in patients with advanced biliary tract cancers
Authors: A. Mambrini, G. Fiorentini, C. Pennucci, M. P. Muttini, A. Manni, A. Del Freo, D. Zamagni, C. Rabbi, F. Sanguinetti, M. Cantore
Journal: Journal of Clinical Oncology (2004)

4197 Background: The prognosis of advanced biliary tract cancer (ABTC) is very poor. Common systemic chemotherapy (CHT) have been reported to produce transient partial remission only in a small proportion of patients (PTS). Aim of this study is to evaluate the effectiveness of regional CHT combined with systemic CHT in PTS with ABTC. Methods: From January 2000 to May 2003, we treated 26 PTS with the combination of intra-arterial CHT (epirubicin 50 mg/sqm and cisplatin 60 mg/sqm, infused bolus by angiographic catheter introduced in proper hepatic artery, with Seldinger technique, on day 1) and e.v. continuous infusion of 5-FU 200 mg/sqm/day, from day 1 to day 14. Cycles were repeated every 3 weeks. 13 PTS were male; median age was 65 years (49–75); performance status was 0–1 in 17 PTS, 2 in 9 PTS; all had hystological confirmed ABTC; 21 PTS had cholangiocarcinoma and 5 PTS had gallbladder carcinoma, with liver involvement > 50% in 10 and < 50% in 16 PTS; three PTS ha peritoneal involvement, 3 had pleural metastases and 2 had bone involvement. Results: 125 cycles were administered, with a median of 6 cycles per patient (1–8); no side effects related to angiographic procedure were observed, while 6 cases of deep venous thrombosis related to central venous catheter occurred. We observed a case of acute pancreatitis and a case of transitory bowel occlusion. Moreover 1 grade III leukopenia, 2 grade III mucositis and 4 grade III alopecia occurred. The overall response rate, including complete response (CR), partial response (PR) and stable disease (SD) was 21/26 (80%); 1 patient had CR, evaluated by positron emission tomography (PET), 8 PTS had PR, 12 had SD and 5 showed a progression of disease. The Ca 19–9 level decreased more than 50% in 11 out of 16 PTS with abnormal baseline level (68%). After a median follow up of 20.5 months (4–47), median survival is 11 months and 1–2 year survival is 42% and 11%, respectively. Median time to progression is 7 months (3–19). Conclusions: This combined regimen appears feasible and safety and shows an interesting response rate and survival in PTS with ABTC. No significant financial relationships to disclose.
CARBON 14 STUDIES
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
FP14.01 WITHDRAWN
Authors: A Mouri, K Tanaka, H Asahina, J Kishimoto, M Okada, K Watanabe, K Hamai, T Harada, Y Tsubata, S Sugawara, K Kobayashi, K Sugio, S Oizumi, I Okamoto
Journal: Journal of Thoracic Oncology (2021)
Correction to: Inhibition of Angiopoietin-Like Protein 3 With a Monoclonal Antibody Reduces Triglycerides in Hypertriglyceridemia
Journal: Circulation (2021)

several corrections to the Data Supplement were needed.1.In Supplemental Table III: Pharmacokinetic Parameters of Total Serum Evinacumab Concentrations, corrections have been made to the data from the multiple ascending dose study: a.For the 150 mg QW SC, 300 mg Q2W SC, and 300 mg QW SC subgroups the data presented for t max , C max and C max /dose have been corrected.b.For the 450 mg Q2W SC subgroup, the mean values for t max and C max have been corrected and the SD values have been corrected for all parameters presented in the table (t max , C max , C max /dose, AUC last , AUC last /dose, AUC tau , CL ss /F).c.For the 450 mg QW SC subgroup, the N values have been corrected from 7 to 6, and the mean, median and SD values have been corrected for all parameters in the table.d.For the 20 mg/kg Q4W IV subgroup, the data presented for t max , C max and C max /dose have been corrected.Also the units for C max /dose have been corrected from 1/L to kg/L, the units for AUC last /dose have been corrected from day/L to day*kg/L, and the units for CL ss /F have been corrected from L/day to mL/day/kg.2. In Supplemental Table VI: Changes Over Time in Liver Function Test Parameters (IU/L) in Patients with Elevations in Creatine Phosphokinase (Single Ascending Dose Study), the data point at Day 4 for Patient 3 (SC placebo) has been corrected from -18 to -13. 3.In Supplemental Table VII: Changes Over Time in Liver Function Test Parameters (IU/L) in Patients with Elevations in Alanine Aminotransferase (Multiple Ascending Dose Study), the study days have been revised from Day 6, 7, 9, 13, 14, 15, 16, 17, 18, and 19 to Day 8, 15, 29, 57, 78, 99, 120, 141, 162, and 183. 4. In Supplemental Table VIII: Changes Over Time in Liver Function Test Parameters (IU/L) in Patients with Elevations in Aspartate Aminotransferase (Multiple Ascending Dose Study), the study days have been revised from Day 6, 7, 9, 13, 14, 15, 16, 17, 18, and 19 to Day 8, 15, 29, 57, 78, 99, 120, 141, 162, and 183. 5.In Supplemental Table IX: Changes Over Time in Liver Function Test Parameters (IU/L) in Patients with Elevations in Creatine Phosphokinase (Multiple Ascending Dose Study), the study days have been revised from Day 6, 7, 9, 13, 14, 15, 16, 17, 18, and 19 to Day 8, 15, 29, 57
MUSCULAR INSUFFICIENCY OF THE MITRAL VALVE.
Authors: CHARLES SPENCER WILLIAMSON
Journal: JAMA (1902)

The conception of a purely muscular insufficiency of the atrioventricular valves is so new a one, that here in America, at least, it has made but little impression upon the great body of physicians who have to do with heart cases. The purpose of this paper is to endeavor, in some small way, to secure for this very important and common group of cases the recognition they deserve, and this not only theoretically but practically at the bedside. <h3>DEFINITION OF MUSCULAR INSUFFICIENCY.</h3> A muscular mitral insufficiency is one in which the valves are anatomically normal, in which the mitral ring is not of such large size that the curtains do not suffice to close it, but in which the valve is incompetent, because of the imperfect functionating of the muscular apparatus of the valve. Until very recently we have been accustomed to think of the closure of the valve as
Basal Cell and Squamous Cell Carcinoma in Persons Younger Than 40 Years
Authors: Kiumarss Nasseri
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Midnight Supper
Authors: Jack Coulehan
Journal: Annals of Internal Medicine (2011)

Ad Libitum18 January 2011Midnight SupperJack Coulehan, MD, MPHJack Coulehan, MD, MPHFrom Setauket, NY 11733.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-154-2-201101180-00005 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Cold spaghetti and thirty two ouncesof Coke at midnight supper. A litteredfoursome, in which the first announcedanother hit to work up. The embitteredsecond stabbed his plastic tray with a pen.The third intern shuffled through a stackof index cards. His wife's father in Johnstownhad just died of cancer. The last attackeda stale Portuguese roll with his fork.Gears grinding, motors turning, but nothinghappening. The ozone-like smell of stale work.Did they suffer from sleep deprivation?Thirty-six on, twelve off. What a sublimemethod of learning the value of time.Jack Coulehan, MD, MPHSetauket, NY 11733 Author, Article, and Disclosure InformationAffiliations: From Setauket, NY 11733.Current Author Address: Jack Coulehan, MD, MPH, 4 Townsend Court, Setauket, NY 11733.The poem is being republished to correct an error that appeared in the 7 December 2010 issue. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 18 January 2011Volume 154, Issue 2Page: 84KeywordsSleep deprivationSmell ePublished: 18 January 2011 Issue Published: 18 January 2011 Copyright & PermissionsCopyright © 2011 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Chairman's Address
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal