tbuckley/cabot-search huggingface dataset:
The nationwide cancer genome screening project in Japan SCRUM-Japan GI-SCREEN: Efficient identification of cancer genome alterations in advanced gastric cancer (GC).
Authors: Satoshi Yuki, Kohei Shitara, Shigenori Kadowaki, Keiko Minashi, Atsushi Takeno, Hiroki Hara, Takeshi Kajiwara, Yu Sunakawa, Satoru Iwasa, Yoshiyuki Yamamoto, Fumio Nagashima, Ryota Nakanishi, Taito Esaki, Takaki Yoshikawa, Shogo Nomura, Takeshi Kuwata, Satoshi Fujii, Wataru Okamoto, Atsushi Ohtsu, Takayuki Yoshino
Journal: Journal of Clinical Oncology (2018)

4050 Background: We have conducted the Nationwide Cancer Genome Screening Project in Japan since April 2015 using Next Generation Sequencing in advanced non-colorectal gastrointestinal (GI) cancer (aNon-CRC), called as the SCRUM-Japan GI-SCREEN. Methods: Patients with aNon-CRC, who plan to or receive chemotherapy were eligible. DNA and RNA were extracted from FFPE tumor samples and were analyzed by the Oncomine Cancer Research Panel (OCP) which allows to detect gene mutation, copy number variant (CNV) and fusions across 143 genes in a CLIA certified CAP accredited laboratory. The detected genomic variant data were classified according to whether genetic drivers of cancer including gain- and loss-of-function or single nucleotide variant based on the Oncomine Knowledgebase. In this presentation, we show the results of advanced gastric cancer (aGC) cohort. Results: From April 2015 to March 2017, a total of 696 aGC samples from 20 cancer centers were analyzed. The sequence with the OCP was successfully performed in 513 (73.7%). The frequently detected mutations were TP53 (47.8%), PIK3CA (9.2%), KRAS (6.0%), SMAD4 (5.1%), APC (4.1%), TET2 (3.9%), ERBB2 (3.3%) and CNVs were ERBB2 (11.3%), CCNE1 (11.1%), KRAS (3.7%), FGFR2 (3.3%), ZNF217 (3.3%), MYC (2.7%), CCND1 (2.3%) and CDK6 (2.1%). FGFR3-TACC3 fusion, EGFR vIII, WIPF2-ERBB2 fusion, and GOPC-ROS1 fusion were detected in 2, 2, 1, and 1 cases, respectively. Seven patients with druggable genomic alterations were enrolled for clinical trials of targeting therapies. We will show the clinical outcome based on certain key cancer genome alterations. Conclusions: This nationwide screening system is efficient to detect rare gene alterations in aGC. This novel knowledge provides an intriguing background to investigate new target approaches and represents a progress toward more precision medicine. This study is still ongoing with newer panel as Oncomine Comprehensive Assay version 3. Clinical trial information: UMIN000016344.
The increasing concern with infertility. Why now?
Authors: S. O. Aral
Journal: JAMA (1983)

A RELATIVELY large number of married American couples of reproductive age are infertile.<sup>1</sup>In 1976, more than one in ten couples had failed to conceive after at least one year of marriage during which no contraceptives were used. Also in 1976, seven percent of American women stated that they had sought professional consultation during the preceding three years to increase their chances of having a baby.<sup>2</sup>Thus, we estimate that almost three in every four couples with a perceived infertility problem actively requested medical evaluation in the mid-1970s. Some authorities believe the demand for infertility services has escalated in recent years.<sup>3</sup> Available data partially support this perception. The estimated number of visits to private physicians' offices for infertility-related consultation increased from approximately 600,000 in 1968 to more than 900,000 in 1972 and remained near that level through 1980 (Table 1). While a slight absolute decrease occurred in
Clinics in general practice.
Journal: BMJ (1976)

and improved fabrics and ventilation have reduced the hazards of bacterial dispersal from the perineum and else- where.23The surgical isolator provides a more radical means of preventing the spread of micro-organisms to the wound from staff and environment.It consists of a transparent plastic tent distended with filtered air under moderate pressure and entirely enclosing the patient-except for his head.24Access is through glove sleeves and entry ports incorporating air locks.These isolators are justifiable in procedures such as hip arthroplasty and open heart surgery, where even airborne coagulase-negative staphylococci may produce disastrous infections.Paradoxically, surgical isolators are also ideal for use when operations have to be performed in makeshift or unhygienic surroundings.More convenient clean operating conditions are provided by laminar airflow systems of the type pioneered by Charnley,25 but inevitably they afford less absolute protection than surgical isolators.Preventing infection at the operation site has not become easier in recent years, but at last it has acquired a firm scientific basis.
Annals of the Rheumatic Diseases, London
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hail Mary
Authors: Ira S. Nash
Journal: JAMA Neurology (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Neurology, Minneapolis
Journal: JAMA (1970)

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Canad Anaesthetists' Society Journal, Toronto
Journal: JAMA (1966)

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CYTOTOXINS AND HEREDITY.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Risk for Cervical Disease in HIV-Infected Women —New York City
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TYPHOID FEVER.
Authors: J. H. SACKRIDER
Journal: JAMA (1900)

It is not to be supposed that the indications for the treatment of typhoid fever could be in all cases exactly alike, yet every case requires absolute rest, perfect ventilation, good nursing and as far as possible, the avoidance of noise. The covering of the bed should be light; the sheets and pillow cases should be changed at least every day; cleaning the patient's mouth and teeth should be attended to three or four times a day, and the most perfect cleanliness of the patient and his bed should be maintained. Fluids ought to be administered freely. Nourishment should be fluid and given often but in small quantities. It is desirable not to overfeed the patient but to give the maximum amount of proper food that can be assimilated. If the fever should be of a mild nature, this may be all or nearly all that is required. If, however,
PWE-015 HER2 expression in the Barrett's metaplasia-dysplasia-carcinoma sequence and potential targeting in vitro with the single chain antibody fragment C6.5
Authors: M A Butt, R J Haidry, D Oukrif, H Pye, I Stamati, G Yahioglu, M Rodriguez-Justo, M R Banks, M P Deonarain, M R Novelli, L B Lovat
Journal: Gut (2012)

<h3>Introduction</h3> There is increasing attention on the integration of targeted agents for oesophageal adenocarcinoma (OA) therapy. The most notable example of success of oesophagogastric targeted therapy was the addition of a HER2 targeting agent in the Phase III ToGA study. However, there is limited data on the expression of HER2 in the progression from Barrett9s (BE) to OA. This study aimed to clarify expression in this sequence, and to show binding of C6.5, a single chain HER2 targeting human antibody Fv fragment (scFv), to known HER2 expressing OA cell lines in vitro. Efficacy of antibody based therapies can be enhanced by scFv9s which penetrate tumours more quickly and demonstrate better tumour: normal tissue specificity. <h3>Methods</h3> 33 paraffin embedded oesophageal tissue specimens were selected from patients with squamous (n=4), non-dysplastic BE (NDBE; n=4), low grade dysplasia (LGD; n=6), high grade dysplasia (HGD; n=8) and OA (n=12). Sections were immunostained with the automated Oracle Bond system (Leica, UK) for consistency. Staining was then scored by 2 expert pathologists according to the proportion of cells in the tissue staining positively as negative (&lt;5%), borderline (5%–10%) or positive (&gt;10%). In phase 2, binding of C6.5 scFv to the cancer cell lines SKOV-3 (ovarian), OE-19, OE-33 (oesophageal) and HT-29 (colon) was identified with flow cytometry using a mouse secondary followed by tertiary anti-mouse FITC. Data were then analysed with FlowJo software. <h3>Results</h3> Significant expression of HER2 (&gt;10% cells positive according to National Guidelines) was only seen in HGD (25%) and cancer (25%) specimens. Borderline staining (5%–10%) was seen in LGD (17%), HGD (13%) and cancer (8%). All NDBE and the remaining LGD, HGD and cancer samples were negative. Flow cytometry demonstrated C6.5 binding to SKOV-3, OE19 and OE-33 cells but not HT-29 cells. <h3>Conclusion</h3> This study demonstrated that significant HER2 expression is only seen in roughly a quarter of patients with HGD and OA and not in NDBE or LGD. We also found that the HER2 targeting scFv C6.5 binds to breast cancer and OA cell lines but not colon cancer, the negative control. HER2 targeting therapies could therefore be postulated for patients with BE with HGD and OA, and these may be enhanced with scFv9s such as C6.5. <h3>Competing interests</h3> None declared.
Transcatheter pulmonary valve dilation for critical pulmonary stenosis: Predictors of outcomes Robert H. Pass, Christine Donnelly, William E. Hellenbrand, Allan J. Hordof, Carl Garabedian, Welton M. Gersony, David E. Solowiejczyk, Daphne T. Hsu. Columbia University College of Physicians and Surgeons, New York, NY
Journal: Journal of the American College of Cardiology (2001)
Highlights
Journal: JAMA (2019)

Transvaginal Mesh Hysteropexy for Uterovaginal Prolapse 1054Transvaginal mesh hysteropexy is an alternative to vaginal hysterectomy for the surgical treatment of uterovaginal prolapse.Nager and colleagues for the NICHD Pelvic Floor Disorders Network randomized 183 postmenopausal women with symptomatic uterovaginal prolapse and found that vaginal mesh hysteropexy, compared with vaginal hysterectomy with uterosacral ligament suspension, did not result in a signifi cantly lower rate of the composite prolapse outcome after 3 years.In an Editorial, Brincat discusses surgical therapies for uterovaginal prolapse and patient-centered assessments of treatment success.
Pharmacokinetics of intravenous recombinant human granulocyte colony‐stimulating factor (rhG‐CSF) in children receiving myelosuppressive cancer chemotherapy: Clearance increases in relation to absolute neutrophil count with repeated dosing
Authors: Marc G. Sturgill, Richard D. Huhn, Richard A. Drachtman, Alice G. Ettinger, Lawrence J. Ettinger
Journal: American Journal of Hematology (1997)

Limited evidence suggests increased efficacy of rhG-CSF by subcutaneous (SQ) compared with intravenous (IV) administration. To examine the possibility that rapid elimination of IV rhG-CSF could substantially shorten the duration of systemic exposure and could explain a difference in pharmacodynamics, we characterized the pharmacokinetic profile of IV rhG-CSF for comparison to that previously reported for SQ administration. Twelve children were randomly assigned to receive 10 or more days of IV rhG-CSF at dosages of 5 or 10 μg/kg a day beginning 24 hr after chemotherapy. Enzyme-linked immunosorbent assay (ELISA) was used to measure rhG-CSF concentrations in timed serum samples on days 1 and 10. Pharmacokinetic parameters were estimated by nonlinear, least squares regression. All serum concentration-time profiles were best described by a two-compartment model of elimination. Mean t1/2β values ranged from 3.68 ± 0.86 to 22.4 ± 12.0 hr. ANC was correlated with log CLT (r = 0.72, P < 0.05), and inversely with log dose-adjusted AUC (r = −0.75, P < 0.05) and log dose-adjusted Cmax (r = −0.65, P < 0.05). Estimated duration of serum rhG-CSF concentrations above 1 ng/ml exceeded 24 hr for all but the 5 μg/kg cohort on day 1. Pharmacokinetic parameters of IV rhG-CSF are similar to those previously reported for SQ administration in children treated with myelosuppressive cancer chemotherapy. Daily IV administration should be suitable alternative route of administration in this patient population. Am. J. Hematol. 54:124–130, 1997 © 1997 Wiley-Liss, Inc.
CAUSE OF THE DELAYED CLOTTING IN HEMOPHILIA
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
GASTROENTEROLOGY
Authors: Joseph B. Kirsner
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Permanent heart substitution: better solutions lie ahead
Authors: W. S. Pierce
Journal: JAMA (1988)

The articles by DeVries et al in this issue ofThe Journaldocument in the scientific literature the events surrounding the much publicized permanent heart replacement using the Jarvik-7 pneumatically powered artificial heart. Their reports define the serious problems that have cast a dark shadow on the currently available pneumatic heart: thromboemboli and infections. Unfortunately, given the present state of the art and science, these problems will not be readily solved. While the tenor of these articles is positive and DeVries and coworkers imply that additional permanent implants will be performed, the suggested solutions to these problems, primarily alterations in patient management, seem unlikely to reduce substantially the incidence of complications. Accordingly, adding patients to this series will serve only to document further the magnitude of the complications rather than to demonstrate an acceptable life-style in the recipient. During the past several years, similar pneumatically powered mechanical hearts have been
Parsing Heterogeneity
Authors: Stephen M. Lawrie
Journal: JAMA Psychiatry (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal