tbuckley/cabot-search huggingface dataset:
Reply
Authors: Lars E. Schmidt, Kim Dalhoff
Journal: Hepatology (2003)

We appreciate the letter by Gow et al. in which hyperphosphatemia was verified as a specific albeit insensitive predictor of death in patients with acetaminophen-induced fulminant hepatic failure.In our study, we only examined the prognostic value of early phosphate concentrations obtained 48 to 96 hours after acetaminophen ingestion. 1At this stage of acetaminophen intoxication, the manifestations of liver failure usually are not developed fully.Indeed, hyperphosphatemia preceded the onset of hepatic encephalopathy in 12 of the 16 patients who fulfilled the proposed phosphate criteria, and coincided with the onset of hepatic encephalopathy in the remaining 4 patients.The median time from fulfillment of the proposed phosphate criteria to death was 8.5 days (range, 1-21 days), and only 3 patients died within 72 hours of having fulfilled the criteria.Thus, the majority of our patients were stable clinically when they fulfilled the proposed phosphate criteria, and would have been eligible for highly urgent liver transplantation.A reason for the conflicting findings by Gow et al. may be if phosphate concentrations obtained later than 96 hours after acetaminophen ingestion were included.Most likely this was the case in the 3 patients who were moribund at presentation.Late phosphate concentrations were not examined in our study and extrapolation of the proposed criteria to include late phosphate concentrations should be made very cautiously.
Effect of Outdoor Airborne Particulate Matter on Daily Death Counts
Authors: Patricia Styer, Nancy McMillan, Feng Gao, Jerry Davis, Jerome Sacks
Journal: Environmental Health Perspectives (1995)

To investigate the possible relationship between airborne particulate matter and mortality, we developed regression models of daily mortality counts using meteorological covariates and measures of outdoor PM10. Our analyses included data from Cook County, Illinois, and Salt Lake County, Utah. We found no evidence that particulate matter < or = 10 microns (PM10) contributes to excess mortality in Salt Lake County, Utah. In Cook County, Illinois, we found evidence of a positive PM10 effect in spring and autumn, but not in winter and summer. We conclude that the reported effects of particulates on mortality are unconfirmed.
Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) antibody blockade in patients previously vaccinated with irradiated, autologous tumor cells engineered to secrete granulocyte-macrophage colony stimulating factor (GM-CSF)
Authors: F. S. Hodi, M. Seiden, M. Butler, F. G. Haluska, I. Lowy, E. Vincent-Brunick, D. Lautz, M. Mihm, G. Dranoff
Journal: Journal of Clinical Oncology (2004)

2536 Background: Vaccination with irradiated, autologous tumor cells engineered to secrete GM-CSF (GVAX) consistently stimulates anti-tumor immune responses, but most patients eventually succumb to progressive disease. Mechanisms to augment the potency of vaccination are required. The attenuation of T cell activation by CTLA-4 represents one potential limitation. In a pilot study of patients previously treated with a variety of vaccination strategies, treatment with a CTLA-4 blocking antibody (MDX-010) induced extensive tumor destruction with lymphocyte and granulocyte infiltrates in 3 of 3 melanoma patients and the reduction or stabilization of CA-125 levels in 2 of 2 ovarian carcinoma patients who previously received GVAX. Methods: We recently undertook a phase I study administering MDX-010 to metastatic melanoma, NSCLC, ovarian cancer, and AML/MDS patients previously immunized with GVAX. Eligibility required measurable disease, no standard curative options, adequate end organ function, and no autoimmune disease requiring immunosuppressive treatment. Patients receive a 3 mg/kg infusion of MDX-010, with repeat dosing possible every 2 months. Results: An additional 2 ovarian patients and one AML patient have been treated to date. One ovarian patient has stable disease; the second had a dramatic reduction in CA-125 from 3478 to 145 with tumor regression after a single dose of MDX-010. No significant toxicities including autoimmune were observed. The trial will accrue 48 patients. Conclusions: CTLA-4 antibody blockade augments effective anti-tumor immunity without inducing autoimmunity in patients previously vaccinated with GVAX. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Medarex, Inc. Medarex, Inc. Cell Genesys; Medarex, Inc.
The Medical Record Visiting List and Physician's Diary for 1896.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
<i>Circulation Research</i> Most Read: 2010–2011
Journal: Circulation Research (2012)

The following represent a selection of the most read Circulation Research articles published between January 2010 and December 2011, presented in reverse order of publication. Articles were selected based on the number of Full Text/PDF downloads, adjusted to compensate for differences in the length of time articles have been available online. As stated in the past, our motivation in compiling such lists of most read articles is multifarious. By highlighting these articles, we wish to direct the attention of our readers to new information that may be of particular interest to a large fraction of the community of cardiovascular scholars. In addition, a synopsis of the most popular articles can be a useful indicator of burgeoning areas of research that are likely to dominate the landscape for years to come. This “honor roll” is also meant to acknowledge the outstanding work of the authors and their efforts in advancing the frontiers of cardiovascular science. Furthermore, we believe that the articles highlighted below represent paradigms of scientific excellence, particularly with respect to the three criteria that we value most at Circulation Research : conceptual and/or mechanistic novelty, scientific impact, and methodological rigor. Finally, we hope that this list will provide tangible evidence of the high (and rising) level of scientific excellence of the work published in Circulation Research .
Radiology
Authors: N. E. Leeds
Journal: JAMA (1989)

Significant advances continue in the use of magnetic resonance (MR) for diagnostic imaging studies. The most important of these exciting developments will be highlighted in this article. Magnetic resonance imaging (MRI) of the appendicular joints provides excellent, detailed resolution of the articular cartilage, synovium, subchondral and cortical bone, and bone marrow.<sup>1</sup>The visualization of joints with MR makes possible excellent discrimination between inflammatory and noninflammatory arthritis of the appendicular skeleton, as reported by Stoller and Genant.<sup>1</sup>Pannus formation, hemosiderin deposits, early articular erosions, and synovitis become clearly visible.<sup>1</sup>The gradient echoes providing T<sub>2</sub><sup>*</sup>effects clearly demonstrate the articular cartilage, which is invisible when using spin-echo T<sub>1</sub>and T<sub>2</sub>imaging.<sup>1</sup> Magnetic resonance imaging is also advantageous in demonstrating the architecture of the spine and, as a result, is helpful in demonstrating metastatic lesions in the vertebrae. Magnetic resonance imaging effectively reveals the presence of
Risks to children from computed tomographic scan premedication
Authors: A. A. Mitchell
Journal: JAMA (1982)

We observed serious adverse reactions after premedication for computed tomographic (CT) head scans and therefore determined rates and risk factors for such reactions among 106 hospitalized children monitored by an intensive drug surveillance program. Reactions occurred in 13 patients (13%), including four cases of life-threatening cardiorespiratory depression or arrest after narcotic premedication. Other reactions included CNS depression, behavior changes, voiding problems, and vomiting. The risk of reaction was elevated in subjects who received high doses of a premedication drug (relative risk, 5.2) and in those who received four or more premedication drugs (relative risk, 3.7). All life-threatening reactions occurred among infants younger than 3 months, and two of these followed medication with only morphine sulfate, in the recommended dose. Risks of adverse reactions from premedication should be considered by physicians who order CT scans for hospitalized children. (<i>JAMA</i>1982;247:2385-2388)
PERC-score: a nephrometry score for percutaneous tumor ablation of small renal mass
Authors: L. Bianchi, P. Piazza, F. Chessa, A. Mottaran, C. Casablanca, M. Droghetti, C. Roveroni, F. Costa, M. Salvador, S. Puliatti, A. Cappelli, C. Gaudiano, A. Bertaccini, E. Marcelli, A. Porreca, B. De Concilio, C. Serra, A. Celia, R. Schiavina, E. Brunocilla
Journal: European Urology (2021)
Autoimmune Hepatitis
Authors: Edward L. Krawitt
Journal: New England Journal of Medicine (1996)

Autoimmune hepatitis is a chronic necroinflammatory liver disorder of unknown cause associated with circulating autoantibodies and a high serum globulin level. Since the first descriptions of the disorder in the 1950s, it has been known by a variety of terms, most commonly "autoimmune chronic active hepatitis," but in 1992 the International Autoimmune Hepatitis Group recommended the term "autoimmune hepatitis" as the most appropriate and least redundant for this disease.1 It is important to distinguish autoimmune hepatitis from other forms of liver disease because a high percentage of cases respond to antiinflammatory and immunosuppressive treatment. Early diagnosis with appropriate management can . . .
Rewards of shared opportunity. The need for updating the Hippocratic covenant of student-teacher relationships
Authors: O. H. Wangensteen
Journal: JAMA (1977)

IT IS anticipated that 13,470 new physicians will have entered the profession of medicine by midyear. From this large group will undoubtedly emerge many future leaders. Perhaps a few will already have been identified by perceptive teachers. Collision with problems demanding solution and intimate association with like minds striving to advance medicine will mold the potential leaders into the achievers, guides, and bellwethers of the next half century. By the fact of their graduation, medical students provide evidence that they fully appreciate the importance of the best known of the Hippocratic aphorisms: "Life is short, the art long, the occasion fleeting, the experiment dangerous, and judgment difficult."<sup>1</sup> How shall I spend my life? Will it be in the service of my fellow men and women? As family physician or specialist? In the academic arena, in community service, or primarily in research? Each has its special compensations. Perhaps no profession
From the editors
Authors: Lucy Bird, Olive Leavy, Kirsty Minton, Yvonne Bordon, Maria Papatriantafyllou, Isabel Woodman, Yukie Ozawa, Catriona Rodwell, Man Tse, Lucie Wootton, Lewis Packwood, Simon Bradbrook, Susanne Harris, Vicky Summersby, Patrick Morgan, Kirsten Lee, Asia-Pacific Publisher, Antoine Bocquet Manager, Koichi Nakamura, Kate Yoneyama, Marketing Manager, Peter Yoshihara, Marketing Production Manager, Takesh Murakami, Harpal Gill, Minton Maria
Journal: Nature reviews. Immunology (2011)
Psychopathic Personality
Authors: A. A. Bartholomew
Journal: BMJ (1958)

<h3>Objective:</h3> To identify factors influencing the success of lumbar puncture (LP) performed by neurology residents in an outpatient clinic. <h3>Background:</h3> There is a need to understand the specific influence of patient or operator characteristics in LP performance in order to identify situations at high risk for failure that could benefit from compensatory interventions. <h3>Methods:</h3> We performed a retrospective analysis of all consecutive patients who underwent elective LP in the Neurology Clinic at the University of Iowa between 2009 and 2012. We recorded demographic, anthropometric, and clinical information, and the level of training of the resident performing the procedure. Outcomes measure was unsuccessful LP, defined as no quantifiable CSF. This study was previously approved by the University of Iowa institutional review board. <h3>Results:</h3> A total of 328 patients (59% women) were included. Men were significantly older than women, and the indication of the procedure differed by sex. Headache or possible multiple sclerosis were more common indications in women than in men. Nineteen percent of the LPs were unsuccessful. We found a strong correlation between patient body mass index (BMI) and unsuccessful outcome (<i>p</i> &lt; 0.0001). Age of the patient and level of training of the operator did not predict unsuccessful LP. <h3>Conclusions:</h3> Patient BMI is the key factor that determines an unsuccessful LP by neurology residents in an outpatient setting, an association that might be applicable to different clinical settings. The high failure rate in patients with BMI &gt;35 suggests that implementing compensatory interventions such as the use of imaging guidance might be cost-effective and better tolerated by these patients.
THE LYMPH GLAND METASTASES IN CARCINOMA OF THE STOMACH.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Respiratory Symptoms and Annoyance in the Vicinity of Coal-Fired Plants
Authors: Goran Pershagen, Niklas Hammar, Erkki Vartiainen
Journal: Environmental Health Perspectives (1986)

This study constitutes one part of a program for assessing the impact of coal-fired power plants on the surrounding communities. A questionnaire was mailed to a total of 12,000 subjects living in six areas with coal-fired plants and in matched reference areas. The participation rate was 77.3%. In one coal-fired plant/reference area pair, a more detailed medical examination was carried out among subjects who reported symptoms of the respiratory tract. The match between coal-fired plant and reference areas was successful primarily in three pairs. Neither respiratory symptoms nor disease rates were increased among adults or children near any of these plants, but one plant seemed to give rise to annoyance. For the remaining coal-fired plants, consistently higher prevalences of respiratory tract symptoms and annoyance were observed in the surrounding population. The effects cannot, however, conclusively be related to the coal-fired plants. It should be pointed out that the air pollution levels were relatively low, also in the vicinity of most of the plants in this study.
Fourth, fifth, and sixth.
Journal: BMJ (1974)

box system has been widely used; but it has been often proved difficult to set up and adjust.Modifications such as the cannu- lation of both nares2 19 have recently been described and make the system easier to use.Further trials are clearly needed of methods which do not require the high degree of medical and nursing skills and complex apparatus which the U.C.H. group have employed so successfully.What is required is a technique which can be set up quickly and easily in the special care unit of any maternity hospital.
OP0310 A Deletion at Adamts9-MAGI1 Locus is Associated with Psoriatic Arthritis Risk
Authors: J. Cañete, J.A. Pinto, J. Gratacόs, R. Queirό, C. Ferrándiz, E. Fonseca, C. Montilla, J.C. Torre-Alonso, L. Puig, J.J. Pérez Venegas, A. Fernández Nebro, E. Fernández, S. Muñoz-Fernández, E. Daudén, C. González, D. Roig, J.L. Sánchez Carazo, P. Zarco, A. Erra, J.L. Lόpez Estebaranz, J. Rodríguez, D. Moreno Ramírez, P. de la Cueva, F. Vanaclocha, E. Herrera, S. Castañeda, E. Rubio, G. Salvador, C. Díaz-Torné, R. Blanco, A. Willisch Domínguez, J.A. Mosquera, P. Vela, J. Tornero, S. Sánchez-Fernández, H. Corominas, J. Ramírez, M. Lόpez-Lasanta, R. Tortosa, N. Palau, A. Alonso, A. Julià, S. Marsal
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Copy-Number Variants (CNV) have been associated to the risk to develop multiple autoimmune diseases. <h3>Objectives</h3> Our objective was to identify CNVs associated with the risk to develop Psoriatic Arthritis (PsA) using a genome-wide analysis approach. <h3>Methods</h3> A total of 835 PsA patients and 1,498 controls were genotyped for CNVs using the Illumina HumanHap610 BeadChip. The most significant CNV associations with PsA risk were independently tested in a sample of 1,133 PsA patients and 1,831 controls. In order to test for the specificity of the variants with PsA etiology, we also analyzed the association to a cohort of 822 purely cutaneous psoriasis (PsC) patients. <h3>Results</h3> A total of 165 common CNVs were identified in the GWAS. We found a highly significant association of an intergenic deletion between <i>ADAMTS9</i> and <i>MAGI1</i> genes (p=0.00014). Using the independent patient and control cohort we validated the association between <i>ADAMTS9-MAGI1</i> deletion and PsA risk (p=0.032). Using next-gen sequencing we characterized the associated deletion. Finally, analyzing the PsC cohort we found a lower frequency of the deletion compared to PsA (p=0.0088) and similar to that of controls (p&gt;0.3). <h3>Conclusions</h3> The GWAS for CNVs has identified a new deletion associated with PsA risk and which is also differential from PsC risk. <h3>Disclosure of Interest</h3> None declared
Cytotoxic Conjugates Containing Translational Inhibitory Proteins
Authors: S Ramakrishnan
Journal: The Annual Review of Pharmacology and Toxicology (1992)

Heme oxygenases (HO) catabolize free heme, that is, iron (Fe) protoporphyrin (IX), into equimolar amounts of Fe2+, carbon monoxide (CO), and biliverdin. The stress-responsive HO-1 isoenzyme affords protection against programmed cell death. The mechanism ...Read More
Abstract 5216: Identification of <i>Sox2</i> regulatory factors in small cell lung cancer
Authors: Hannah Wollenzien, Mira Yousef, Ellen Voigt, Michael S. Kareta
Journal: Cancer Research (2019)

Abstract Sox2 is one of the core pluripotency genes that has also been implicated to be oncogenic in a multitude of cancers. We have shown that Sox2 is required for the formation of SCLC using mouse models and human cell culture. SCLC predominantly arises from in the lung from pulmonary neuroendocrine cells, which are formed from Sox2-expressing progenitors that are then silenced upon terminal differentiation. However, upon transformation Sox2 becomes highly upregulated in SCLC. One means of repressing Sox2 is the Rb tumor suppressor, which binds to the Sox2 locus and represses transcription by the recruitment of many epigenetically silencing factors. However, there are still some gaps in our knowledge of the repression of Sox2 by Rb, such as which factors are recruiting Rb to Sox2. We describe a novel technique of Cre-mediated Protein-DNA Immunoprecipitation (CrePI) to identify proteins at the Sox2 locus in an unbiased manner to further elucidate the mechanism of Rb repression of Sox2. Citation Format: Hannah Wollenzien, Mira Yousef, Ellen Voigt, Michael S. Kareta. Identification of Sox2 regulatory factors in small cell lung cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 5216.
Tranquilizer Control
Authors: Barry Blackwell
Journal: JAMA (1973)

<h3>To the Editor.—</h3> The paper on tranquilizer control by Kaufman et al (221:1504, 1972) raised some interesting questions of methodology and interpretation. A somewhat similar report was made at this year's meeting of the American Psychiatric Association by Drs. Keeler and McCurdy who observed what happened when selected minor tranquilizers were banned from use in a state Medicaid program. In that case, about 35% of prescriptions were replaced by increased use of barbiturates and phenothiazines, but 65% were not replaced by any drugs. The implication behind both these studies is that there is extensive overuse of minor tranquilizers among patients. Yet neither paper produced any evidence to support this contention. In the study by Dr. Kaufman and colleagues, the number of prescriptions for tranquilizers before "control" was instituted was 278 in an estimated patient-contact load of 3,000 in the two-month period. This means that 1 of every 11 patient contacts
Verb Omitted
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal