tbuckley/cabot-search huggingface dataset:
Strain Differences in Vaginal Responses to the Xenoestrogen Bisphenol A
Authors: Xinghua Long, Rosemary Steinmetz, Nira Ben-Jonathan, Andrea Caperell-Grant, Peter C. M. Young, Kenneth P. Nephew, Robert M. Bigsby
Journal: Environmental Health Perspectives (2000)

Bisphenol A (BPA) is the monomer component of polycarbonate plastics and epoxy resins; human exposure derives from leachate in foodstuffs packaged in certain plastics or from epoxy-based dental appliances. BPA stimulates prolactin secretion in Fischer 344 (F344) rats but not in Sprague-Dawley (S-D) rats. The present studies were performed to determine if another classic estrogen target tissue, the rat vagina, responds to BPA in a strain-specific manner. In F344 rats BPA increased DNA synthesis in vaginal epithelium with a median effective dose (ED(50)) of 37.5 mg/kg body weight; DNA synthesis was not stimulated in S-D rats by any dose tested. Clearance of (3)H-BPA from blood followed the same time course in both strains of rats, with a half-life of 90 min. Scatchard analysis of [(3)H]estradiol binding showed no strain differences in concentration or affinity of the vaginal estrogen receptor. BPA increased the level of mRNA for the immediate early gene, c-fos, with similar dose-response curves in both rat strains. Thus, F344 and S-D rats exhibit differences in sensitivity to BPA at the level of cell proliferation in the vaginal epithelium. However, metabolic clearance of BPA and the early events that lead to the proliferative response, receptor-ligand interaction and induction of immediate early genes, show no strain differences. These observations suggest that differences in intermediate effects must account for the difference in sensitivity of the proliferative response to the xenoestrogen. Furthermore, these results point to the need for caution in choosing a suitable end point and animal model when seeking to test the estrogenic effects of xenobiotics.
T- and B-cell responses to different hepatitis C virus antigens in patients with chronic hepatitis C infection and in healthy anti- hepatitis C virus-positive blood donors without viremi
Authors: M Lechmann
Journal: Hepatology (1996)

As the host's immune response may determine the course of hepatitis C virus (HCV) infection, we studied the humoral and cellular immune responses to HCV-related antigens in subjects with different outcomes of HCV infection. Lymphoproliferative responses and circulating antibodies to a panel of HCV core- and E1-related 25-mer peptides were examined in 10 healthy anti-HCV-seropositive blood donors (group A) and in 29 patients with chronic hepatitis C (group B). In addition, cellular recognition of recombinant HCV proteins (core, NS3, NS4A, NS5A, NS5B) were investigated. In group A, stronger T-cell responses were detected against both HCV proteins (core, P = .03; NS4, P = .005; NS5B, P = .03) and peptides. Proliferation was induced by the same peptides in each group, defining at least five distinctive epitopes within core (amino acids [aa] of 20-44, aa 39-63, aa 79-103, aa 118-152 and aa 148-172) and three regions within E1(aa 198-252, aa 308-372, and aa 368-392). Subjects with strong T-cell responses had low or no detectable levels of peptide-specific antibodies, and vice versa. In particular, T-cell responses were more common in group A; B-cell responses were more common in group B. From our data, we conclude that a benign course of HCV infection may be the consequence of the effective activation of T-helper lymphocytes. (Hepatology 1996 Oct;24(4):790-5)
Abstract P031: Mediation Effect of Abdominal Adiposity Between Sedentary Lifestyle and Blood Pressure in General Population From a Middle-income Country
Authors: Mauricio V Herrera, Johanna Otero, Christian Clausen, Silvia González-Gómez
Journal: Circulation (2017)

Background: Hypertension is a highly prevalent risk factor for cardiovascular disease (CVD). Middle-income countries have experienced accelerated urbanization resulting in a growing prevalence of sedentary lifestyle (SL) behavior and a trend toward obesity that might explain population-level changes in blood pressure (BP). We aimed to evaluate the association of SL and adiposity on BP. Methods: We analyzed data from two surveys conducted on representative samples (15-64 years old) from Santander (Colombia) in 2010 (n=2,419) and 2015 (n=2,158) following the WHO STEPwise approach to assess risk factors for CVD. Physical activity was measured using the GPAQ questionnaire and SL was defined as the lowest level of activity according to the WHO criteria. We measured waist circumference (WC [cm]) and calculated body mass index (BMI [kg/m 2 ]) and waist-to-hip ratio (WHR) as indexes of adiposity. BP was measured using an Omron® automatic monitor in sitting position (average of two measurements). Associations were estimated, incorporating post-stratification weights, using censored normal multiple regression (accounting for antihypertensive therapy) and mediation approached by Baron’s criteria. Results: Mean systolic/diastolic (S/DBP) were 119.2 (95%CI: 118.7-119.7) / 73.7 (95%CI: 73.4-74.1) mmHg and 1 out 6 participants were hypertensive (2015/2010 prevalence ratio=1.02, p&gt;0.050). BMI, WC and WHR were positively and significantly correlated with systolic (r=0.16, r=0.39, and r=0.41) and diastolic BP (r=0.18, r=0.38, and r=0.33). Sedentary as compare to active participants had higher age- and sex-adjusted WC (1.1 cm, p=0.008) and WHR (0.01 units, p&lt;0.001). SL prevalence was 62.0% (95%CI: 59.8-64.1) and changed across tertiles of SBP (66.4%, 60.3%, and 59.6%) and DBP (59.3%, 63.1%, and 63.1%); however, SL was only associated to higher DBP after adjustment by age, sex, and area of residency (0.8 mmHg, p=0.036). Further inclusion of BMI, WC, or WHR attenuated the strength of the association in 16.7%, 42.3%, and 61.7%, respectively. There was no survey-by-sedentary lifestyle interaction. Conclusion: SL is highly prevalent in a middle income country such as Colombia. We confirmed the association of this behavioral risk factor and DBP but not SBP. Furthermore, the attenuation of such relationship by anthropometric indexes, particularly of abdominal obesity, suggests a mediation effect of adiposity that must be validated in longitudinal studies.
UP-TO-DATE JOURNALS.
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Notice of Retraction
Journal: Circulation (2012)

The authors of the following article have requested that it be retracted from publication in Circulation: Kawakami A, Osaka M, Tani M, Azuma H, Sacks FM, Shimokado K, Yoshida M. Apolipoprotein CIII links hyperlipidemia with vascular endothelial cell dysfunction. Circulation. 2008;118:731–742. The corresponding author, Dr Akio Kawakami, reported to the editors that the authors of this manuscript have raised concerns related to the accuracy of the data presented in this article. In the process of following up the findings reported in this study, they were unable to reproduce some experiments due to Dr Akio Kawakami's negligence in keeping proper original records. This information was reported to the editors by Dr Kawakami directly. The authors apologize to the readers of Circulation for any inconvenience caused by this retraction.
Diabetes Mellitus
Authors: Elliott P. Joslin
Journal: New England Journal of Medicine (1945)

IN THE following remarks on the progress in the treatment of diabetic coma and of pregnancy in diabetes I have confined myself to data from the George F. Baker Clinic for four reasons: they are more favorable and based on larger numbers of cases than are those reported elsewhere; it would be unfair to cite comparative data from other sources, because such reports often represent the results of treatment by many doctors, possibly with different ideas, on different services in a hospital and where, perhaps, the senior members of the staff are able to take a less active part in . . .
Alkaline phosphatase (ALP) normalization and overall survival in patients with bone metastases from castration-resistant prostate cancer (CRPC) treated with radium-223.
Authors: S. Nilsson, C. G. O'Bryan-Tear, B. Bolstad, A. Lokna, C. C. Parker
Journal: Journal of Clinical Oncology (2011)

4620^ Background: Radium-223 (Alpharadin) is a first-in-class alpha-pharmaceutical. It targets bone metastases with high-energy alpha-radiation of extremely short range that spares bone marrow. Radium-223 has a profound effect on serum markers of bone metabolism, including ALP, in patients with bone metastases from CRPC. In an exploratory analysis, we studied whether this effect is associated with a meaningful clinical benefit. Methods: Patients with CRPC and bone metastases were treated in 2 randomized phase II studies. BC1-02 was a placebo-controlled study of radium-223 (50 kBq/kg) every 4 weeks for 12 weeks. BC1-04 evaluated radium-223 (25, 50, or 80 kBq/kg) every 6 weeks for 12 weeks. Baseline total ALP values > 128 U/L were considered elevated; those decreasing to below 128 U/L during treatment with radium-223 were defined as normalized, and those remaining above that value as nonnormalized. Results: In BC1-02, ALP normalization was seen in 12/26 (46%) patients treated with radium-223. Median survivals of those with and without ALP normalization were 102 weeks and 42 weeks, respectively (log-rank P < 0.001). In BC1-04, ALP normalization was seen in 25/75 (33%) cases: 5/29 (17%) in the 25 kBq/kg group, 10/25 (40%) with 50 kBq/kg, and 10/21 (48%) with 80 kBq/kg, indicating a dose-response relationship. Median survivals for the 25 patients with, and the 50 patients without, ALP normalization were 102 weeks and 58 weeks, respectively (log-rank P = 0.0086). Conclusions: In patients with metastatic CRPC and bone metastases treated with radium-223, ALP normalization was associated with significantly better overall survival. These data support the rationale for the ongoing ALSYMPCA phase III trial of radium-223.
Efficacy of pentavalent rotavirus vaccine against severe rotavirus gastroenteritis in infants in developing countries in sub-Saharan Africa: a randomised, double-blind, placebo-controlled trial
Authors: George E Armah, Samba O Sow, Robert F Breiman, Michael J Dallas, Milagritos D Tapia, Daniel R Feikin, Fred N Binka, A Duncan Steele, Kayla F Laserson, Nana A Ansah, Myron M Levine, Kristen Lewis, Michele L Coia, Margaret Attah-Poku, Joel Ojwando, Stephen B Rivers, John C Victor, Geoffrey Nyambane, Abraham Hodgson, Florian Schödel, Max Ciarlet, Kathleen M Neuzil
Journal: The Lancet (2010)
SOME NORMAL STANDARDS FOR THE DETECTION OF ABNORMAL PHYSIOLOGIC PERFORMANCES
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Michigan Students Protest.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hepatic 60-kD heat-shock protein responses in alcoholic hepatitis
Authors: J Koskinas
Journal: Hepatology (1993)

The precise mechanism of the pathogenesis of alcoholic hepatitis is unknown, but immune involvement may perpetuate and exacerbate the process. Heatshock proteins, normally protective, may be immunogenic and have been shown to induce antibody formation in some inflammatory conditions. Alcohol, cellular hypoxia and tumor necrosis factor, all involved in alcoholic hepatitis, are potent inducers of heatshock protein. In this study, we sought 60-kD heatshock protein in liver tissue with a murine monoclonal antibody and measured circulating antibody to 60-kD heat-shock protein on ELISA. Fourteen of 20 livers from patients with acute alcoholic hepatitis expressed 60-kD heat-shock protein in hepatocyte cytoplasm in a diffuse pattern with superimposed clusters; other cell types were occasionally positive. Twelve of these patients had high-titer IgA 60-kD heat-shock protein antibody in serum. In contrast, 60-kD heat-shock protein was identified in only 2 of the 10 patients with alcoholic cirrhosis without hepatitis (p = 0.013). These two patients had severe liver disease, and one patient in this group was seropositive for IgA 60-kD heat-shock protein antibody. Eight alcoholic patients with fatty liver alone were negative for antigen, and all but one were negative for antibody. The 10 patients without liver damage were negative for antigen and antibody. The findings that 60-kD heat-shock protein is present in liver tissue of patients with acute alcoholic liver damage and that circulating IgA 60-kD heat-shock protein antibody levels are increased may point to one pathogenetic mechanism underlying development and progression of liver damage in alcoholic hepatitis. (HEPATOLOGY 1993;17:1047–1051.)
Poles apart
Authors: Lynn Eaton
Journal: BMJ (2008)

<h3>Abstract</h3> In addition to its known roles in protein synthesis and enzyme catalysis, RNA has been proposed to stabilize higher-order chromatin structure. To distinguish presumed architectural roles of RNA from other functions, we applied a ribonuclease digestion strategy to our CUT&amp;RUN in situ chromatin profiling method (CUT&amp;RUN.RNase). We find that depletion of RNA compromises association of the murine nucleolar protein Nucleophosmin with pericentric heterochromatin and alters the chromatin environment of CCCTC-binding factor (CTCF) bound regions. Strikingly, we find that RNA maintains the integrity of both constitutive (H3K9me3 marked) and facultative (H3K27me3 marked) heterochromatic regions as compact domains, but only moderately stabilizes euchromatin. To establish the specificity of heterochromatin stabilization by RNA, we performed CUT&amp;RUN on cells deleted for the <i>Firre</i> long non-coding RNA and observed disruption of H3K27me3 domains on several chromosomes. We conclude that RNA maintains local and global chromatin organization by acting as a structural scaffold for heterochromatic domains.
Lactate Dehydrogenase as a Biomarker of Hemolysis-Associated Nitric Oxide Resistance, Priapism, Leg Ulceration, Pulmonary Hypertension and Death in Patients with Sickle Cell Disease.
Authors: Gregory J. Kato, Vicki McGowan, Roberto F. Machado, Jane A. Little, James Taylor, Claudia R. Morris, James S. Nichols, Xunde Wang, Mirjana Poljakovic, Sidney M. Morris, Mark T. Gladwin
Journal: Blood (2005)
Community-wide emergency medical services. Recommendations by the Committee on Acute Medicine of the American Society of Anesthesiologists
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
1B: Immunological aspects leading to vaccine against H. pylori
Authors: C Kreiss, T Buclin, M Cosma, J Biollaz, I Corthnisy-Theulaz, N Porta, M Glauser, M Appenzeller, J Pappo, R Nichols, M Stolte, T Monath, A Blum, M Camorlinga-Ponce ', A Escobar-Lujfin', B Gonzilez-Ortiz', A Madrazo-De La Garza', G Pnrez-P6rez, M Dehesa', J Torres', F Buck', F Radcliff', J O'rourke', A Lee', C Doidge, J Bureg, L Phlfkovi, S Rejchrt, M ~irok~, V Pali6ka
Journal: Gut (1996)

Oral immunization with H. pyloni unease induces the cure of Helicobacter infection in animal models, when administered with an adjuvant.As a first step to use therapeutic immunization in humans, we studied the safety and the immunogenicity of recombinant, enzymatically inactive urease in H. pylori-infected adults.Methods: 12 healthy adults (21-39 yrs.) with documented asymptomatic H. pyloni infection, participated in a double- blind, placebo-controlled phase 1 study and were randomized to receive 60 mg recombinant urease po or placebo once weekly for 4 weeks.Clinical examination and safety laboratory tests were performned at regular intervals.Gastric biopsies obtained at baseline and one month after the last dose were scored for inflammation.mucosal damage, and H. pyloni density according to a modified Sydney system and were analysed by immunocytochemistry.Urease-specific antibody-secreting cells (ASC) were measured in peripheral blood by ELISPOT and antibodies to urease were determined in saliva and serum.Results: The administration of urease was well tolerated and no serious adverse events occurred.No clinically relevant abnormnalities in blood count or chemistry were observed.All baseline gastroscopies were normnal except for antral non-erosive gastritis.At the end of the study, iso- lated erosions were noted in 2 volunteers having received placebo and in 3 having received urease.No change in the total gastritis score for corpus and antrum was observed.All subjects remained infected throughout the study ('"C-urea breath test, culture, and histology).ASC were found in gastric mucosa of most subjects and there was no evidence that immunization with urease enhanced the local antibody response.No urease-specific ASC were detected in peripheral blood throughout the study.Antibodies to urease were detected in saliva and serum of all subjects.Serum IgG and IgA anti-urease titers remained unchanged in all volunteers.One of six subjects having received the test product developed a borderline increase (3.4 fold) in salivary anti-urease IgA.No change in salivary anti-urease IgA was seen in other volunteers.Conclusion: The administration of recombinant urease in H. pyloni infected, asymptomatic adults is well tolerated.As expected, urease is not immunogenic in humans in the absence of an adjuvant.The safety of oral immunization with urease and an adjuvant is currently being tested in humans.
Molecular And Cellular Basis Of Chemically Induced Immunotoxicity
Authors: M. Luster
Journal: The Annual Review of Pharmacology and Toxicology (1987)

Heme oxygenases (HO) catabolize free heme, that is, iron (Fe) protoporphyrin (IX), into equimolar amounts of Fe2+, carbon monoxide (CO), and biliverdin. The stress-responsive HO-1 isoenzyme affords protection against programmed cell death. The mechanism ...Read More
Massachusetts Medical Society
Authors: Eliot Hubbard
Journal: New England Journal of Medicine (1977)

The kindly, conservative gentleman who served as treasurer of the Massachusetts Medical Society for 28 years (1943 to 1971) — a longer period than that covered by any of his predecessors since the foundation of the Society in 1781 — is affectionately remembered not only by those associated with him at 22 Fenway but also by his surviving patients, his past and present associates on the staff of the Children's Hospital and everyone who participated with him in a variety of hobbies and extracurricular activities. He died on January 28, 1977, at the age of 83, and is survived by . . .