tbuckley/cabot-search huggingface dataset:
2017 EULAR recommendations for a core data set to support observational research and clinical care in rheumatoid arthritis
Authors: Helga Radner, Katerina Chatzidionysiou, Elena Nikiphorou, Laure Gossec, Kimme L Hyrich, Condruta Zabalan, Yvonne van Eijk-Hustings, Paula R Williamson, Andra Balanescu, Gerd R Burmester, Loreto Carmona, Maxime Dougados, Axel Finckh, Glenn Haugeberg, Merete Lund Hetland, Susan Oliver, Duncan Porter, Karim Raza, Patrick Ryan, Maria Jose Santos, Annette van der Helm-van Mil, Piet van Riel, Gabrielle von Krause, Jakub Zavada, William G Dixon, Johan Askling
Journal: Annals of the Rheumatic Diseases (2018)

Personalised medicine, new discoveries and studies on rare exposures or outcomes require large samples that are increasingly difficult for any single investigator to obtain. Collaborative work is limited by heterogeneities, both what is being collected and how it is defined. To develop a core set for data collection in rheumatoid arthritis (RA) research which (1) allows harmonisation of data collection in future observational studies, (2) acts as a common data model against which existing databases can be mapped and (3) serves as a template for standardised data collection in routine clinical practice to support generation of research-quality data. A multistep, international multistakeholder consensus process was carried out involving voting via online surveys and two face-to-face meetings. A core set of 21 items ('what to collect') and their instruments ('how to collect') was agreed: age, gender, disease duration, diagnosis of RA, body mass index, smoking, swollen/tender joints, patient/evaluator global, pain, quality of life, function, composite scores, acute phase reactants, serology, structural damage, treatment and comorbidities. The core set should facilitate collaborative research, allow for comparisons across studies and harmonise future data from clinical practice via electronic medical record systems.
Psychoneuroimmunology.
Authors: N Cohen, H Kehrl, B Berglund, A O'Leary, G Ross, J Seltzer, C Weisel
Journal: Environmental Health Perspectives (1997)

This paper develops hypotheses regarding the interactions among stress, immunity, and chemical sensitivities and gives an overview of the questions and hypotheses generated by a working group exploring the application of psychoneuroimmunology to chemical sensitivities. Consideration is given to prospective longitudinal studies designed to find cases among at-risk exposed populations. Relevant immune parameters to be measured longitudinally and in challenge studies for patients with MCS are discussed. Immune system changes in response to the chronic stress of having MCS and as primary responses to chemical exposure also are considered.
International Conferences on Emerging Infectious Diseases
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
New agenda for general practice computing.
Journal: BMJ (1990)

large proportion of the daily calcium requirements, may well reduce the prevalence of bladder stones,7 but again, the effect of differing water hardness on the distribution of stones is completely unknown.Development may result in endemic stones disappearing, but there is no evidence that the poor of the bladder stone belt in Asia have reached the stage of the declining disease experienced by the poor in England at the turn of the century.
THE DIPHTHERIA PROBLEM
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Phase 1B trial of ADI-PEG 20 (A) plus nab-Paclitaxel (nab-P) and gemcitabine (gem) in subjects with advanced pancreatic cancer (APC).
Authors: Maeve Aine Lowery, Marinela Capanu, Danielle C. Glassman, Christina M. Covington, Jill Gluskin, Robin Brenner, Chien-Feng Li, John S. Bomalaski, Amanda Johnston, Adalberto Barba, Kenneth H. Yu, David Paul Kelsen, Ghassan K. Abou-Alfa, Leonard Saltz, Eileen Mary O'Reilly
Journal: Journal of Clinical Oncology (2016)

e15756 Background: ADI-PEG 20 (A) is a pegylated form of an arginine depleting enzyme, arginine deaminase. Normal cells can synthesise arginine from citrulline using the enzyme argininosuccinate synthetase (ASS). A selectively targets malignant cells which lack ASS. Preclinically A has monotherapy activity in PC, and demonstrated synergistic activity with gem and taxanes . This trial evaluated the safety and preliminary activity of A combined with gem and nab-P in patients with APC. Methods: Eligibility: Metastatic PC, ≤ 1 line prior treatment (dose escalation cohort:ct) no prior treatment (expansion ct), ECOG 0-1. Treatment: gem 1000mg/m2, nab-P 125mg/m2 3 out of 4 weeks, A 18mg IM weekly (ct 1), then A 36mg weekly (ct 2 and expansion ct). Primary endpoint: MTD of A in combination with nab-P and gem. Statistical plan: Single arm, non-randomized, open-label, phase Ib, standard 3 + 3 dose escalation with expansion ct of N = 9 at MTD. Secondary endpoints: progression-free survival (PFS), response rate, overall survival (OS), safety, tolerability, blood and archival tumor analyses for ASS expression and immunogenicity. Results: Between 11/14 and 09/15, 18 pts enrolled. 4 pts (22%) had 1 prior line of therapy. Toxicity attributable to A was limited to grade 1 rash / erythema at injection site (n = 3). Cohort 2 was expanded to 6 pts due to DLT of elevated LFTs, no further DLTs observed. ≥ grade 3 toxicity attributable to gem and/or nab-P included elevation in AST/ALT, hematologic toxicity, fatigue, diarrhea, neutropenic fever, alopecia as expected. No A related grade 3-5 toxicities were observed. Response: 8 pts (44%) PR, including one previously treated pt, 8 pts (44%) stable disease (SD), 1 (12%) pt clinical progressive disease (PD) before 1st scan. 9 pts continue on study treatment, PFS 7.2 months (95%CI 4.8-9.5) median OS not reached. Of 11 archival tumors samples tested for ASS expression by IHC, 5/11 were deficient. Conclusions: Full dose A was safely combined with gem and nab-P. Activity was observed in previously treated and untreated pts, and in patients with ASS deficient and proficient tumors.Potential benefit of A with cytotoxics in APC may be independent of ASS status. Clinical trial information: NCT02101580.
Abstract 1237: Down-regulation of chemokine receptor CXCR4 by gambogic acid suppresses metastasis of pancreatic cancer in an orthotopic mouse model
Authors: Sahdeo Prasad, Sanjay Srivastava
Journal: Cancer Research (2019)

Abstract More than 90% of patients die of pancreatic cancer due to metastasis. Among the cytokines, CXCL12 and its CXC chemokine receptor 4 (CXCR4) are known to play a role in invasion and metastasis in many types of cancer. Thus, agents that can interrupt the CXCR4/CXCL12 signaling cascade have the potential to suppress cancer metastasis. In the present study, we demonstrate that gambogic acid (GA), a xanthone from Gamboge hanburyi, down-regulated CXCR4 expression in pancreatic cancer cells in a dose- and time-dependent manner. We found that the decrease in CXCR4 by GA was not specific to cell type since its expression was abrogated in multiple myeloma cell lines and in colorectal, head and neck, prostate, and breast cancer cell lines. Furthermore, down-regulation of CXCR4 was not due to proteolytic degradation since proteasome inhibitors had no effect. Instead, the down-regulation of CXCR4 was due to transcriptional regulation, as indicated by the corresponding down-regulation of mRNA expression. This xanthone also inhibited the invasion of pancreatic tumor cells in vitro. Down-regulation of CXCR4 and prevention of cell invasion by the xanthone were both found to be mediated through the reactive oxygen species (ROS) as N-acetylcysteine, a ROS quencher, abolished these effects. When examined in an orthotopic nude mouse model of human pancreatic cancer, intraperitoneal administration of GA suppressed both tumor growth and metastasis. Immunohistochemical analysis of tumor tissue showed that besides decreasing the level of CXCR4, GA also reduced the expression of VEGF and MMP-9, which are also linked to invasion and metastasis. Thus, our results demonstrate gambogic acid’s potential in suppressing tumor invasion and metastasis through down-modulation of CXCR4/CXCL12 signaling pathways. Citation Format: Sahdeo Prasad, Sanjay Srivastava. Down-regulation of chemokine receptor CXCR4 by gambogic acid suppresses metastasis of pancreatic cancer in an orthotopic mouse model [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1237.
Thoracolumbar neural arch fractures. Evaluation by hypocycloidal tomography
Authors: B. M. Casey
Journal: JAMA (1973)

Twenty-eight patients with trauma involving the thoracic lumbar spine were examined by both conventional roentgenography and hypocycloidal tomography. The latter technique demonstrated 12 neural arch fractures of which only two were identified on the initial interpretation of the conventional roentgenograms. When these were reexamined, the fractures were correctly identified in eight instances, but there were five false-positive interpretations as well. In each case, exact delineation of the injury was best achieved by hypocycloidal tomography.
ESGE Newsletter
Journal: Endoscopy (2009)

At the United European Gastroenterology Week (UEGW), the ESGE Lecture Theatre offers highly popular small-forum lectures held by select topic experts. Limited attendance numbers allowed participants to study in more detail techniques and procedures of their choice in high quality video presentations. The ESGE now offers a selection of these lectures presented as PowerPoint slide-shows featuring synchronized audio narratives on the ESGE website at www.esge.com. Presently ten talks from the Paris UEGW are featured and those from Vienna, 2008 will be posted in the near future:
Influence of viral quasispecies on effectiveness of interferon therapy in chronic hepatitis C patients
Authors: Y Kanazawa
Journal: Hepatology (1994)

The quasispecies nature of hepatitis C virus genome distribution is most evident in hypervariable regions of the putative envelope 2 domain. Eight patients with chronic hepatitis C treated with interferon-α were studied as to heterogeneity of the hypervariable regions to clarify the implications of quasispecies. More than 10 recombinant clones generated from polymerase chain reaction-amplified products of the hypervariable regions were sequenced. The sets of clones derived from long-term responders before interferon therapy showed a significantly lower (p < 0.05) degree of sequence complexity of the hypervariable region 1 quasispecies than those from short-term ones or nonresponders. The values of nucleotide diversity (the average number of nucleotide differences per site between two randomly chosen sequences) in hypervariable region 1 before interferon therapy were also significantly lower (p < 0.05) for long-term responders (mean, 2.31 × 10) than for short-term ones or nonresponders (13.02 × 10−2). In some cases, nucleotide diversity decreased remarkably during interferon therapy, whereas the values remained unchanged in other cases. In one interesting case, a short-term response was first noted with the nucleotide diversity decreasing from 13.98 × 10−2 to 0.21 × 10−2; namely, the diversity of the quasispecies was significantly reduced, and then a long-term response was observed after an additional course of interferon therapy. Thus, the degree of quasispecies' complexity and diversity of hypervariable region 1 was closely correlated with the responsiveness to interferon therapy in chronic hepatitis C patients, and thus may have some influence on interferon efficacy. (Hepatology 1994;20:1121–1130).
Silent myocardial ischemia. Is the person or the event silent?
Authors: A. J. Barsky
Journal: JAMA (1990)

The symptoms of organic disease vary widely among patients with the same tissue abnormality, because the experience of a symptom is shaped by the patient's perceptual and cognitive style. Thus, the relationship between myocardial ischemia and chest pain is variable in that many patients experience pain without ischemia and many others exhibit ischemia without pain—termed "silent" or "asymptomatic ischemia." Although the nature of the ischemic event may be important in determining the degree of associated pain, we suggest more study of the individual who perceives the event. Myocardial ischemia may not generate a spontaneous report of chest pain because the patient is generally hyposensitive to visceral sensation; because he or she is coping with the threat of heart disease by denying the evidence of it—ie, denying the pain to deny the disease; or because the patient misunderstands the cause and significance of a vague or ambiguous cardiac sensation, normalizing the symptom and misattributing it to a nonpathologic cause. (<i>JAMA</i>. 1990;264:1132-1135)
Apple News
Authors: Shuntaro Obi, Shinpei Sato, Toshihiro Kawai, Shintaro Ichikawa, Tomoaki Ichikawa, Utaroh Motosugi, Katsuhiro Sano, Hiroyuki Morisaka, Nobuyuki Enomoto, Masanori Matsuda, Hideki Fujii, Masakatsu Tsurusaki, Takamichi Murakami, Tae Wook Kang, Hyunchul Rhim, Diana L. Borgas, Jin-Song Gao, Ming Tong, Suzanne M. de la Monte, Druckerei Stückle, Druckerei Stückle
Journal: Liver Cancer (2015)
Juxtaglomerular Cells
Authors: PHYLLIS M. HARTROFT
Journal: Circulation Research (1963)

Morphological and ultrastructural characteristics of JG cells are consistent with the concept of secretory or endocrine activity. At least in the chronic situation, evidence indicates that hypergranulation of JG cells--or elevated JGI--means hyperactivity. Factors that control cytological activity of JG cells are concerned with volume or pressure changes and with sodium. Despite the influence of potassium in the adrenal zona glomerulosa, potassium does not affect JG cells. The fluorescent antibody technique in the rabbit, dog, and domestic pig, demonstrates that renin is located in the JG cells, but not in the macula densa or other structures of the renal cortex. Inhibition of sodium retention by antirenin in sodium-deficient dogs provides further evidence that renin, secreted by JG cells, is concerned in the regulation of sodium excretion, whether by its influence on aldosterone or by an intrarenal mechanism.
Tobacco, Alcohol, and Other Drug Use Among High School Students—United States, 1991
Journal: JAMA (1992)

In the United States, use of tobacco, alcohol, and other drugs is associated with the leading causes of morbidity and mortality (e.g., motor-vehicle crashes, homicide, suicide, and cancer [1]), with lower educational achievement, and with school dropout (2-5). This report presents self-reported data about the prevalence of tobacco, alcohol, marijuana, and cocaine use among students in grades 9-12 from two school-based components of the Youth Risk Behavior Surveillance System (6): 1) state and local Youth Risk Behavior Surveys (YRBSs) conducted by departments of education in 23 states and 10 cities during the spring of 1991 and 2) the national YRBS conducted during the same period.
S.A. Tissot (1728-1797). Layman's guide to health
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ABORTION.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Motor vehicle childhood injuries caused by noncrash falls and ejections
Authors: P. F. Agran
Journal: JAMA (1985)

In a sample of children aged O through 14 years who were treated for injuries incurred in a motor vehicle accident, a large proportion of those involved in noncrash events fell or were ejected from the vehicle. This study was designed to describe the patterns of passenger travel, precipitating causes, and severity of injury in noncrash falls or ejections. The data were obtained from a larger ongoing hospital-based monitoring system. The Abbreviated Injury Scale was used to grade injuries. Over 50% of those ejected sustained serious injuries compared with 5% of those who remained in the vehicle. Two high-risk patterns emerged: (1) the young child traveling in a passenger seat falling out of the vehicle, and (2) the older child riding on the exterior of the vehicle and falling off during a vehicle maneuver. Door locks, restraint use, and prohibition of travel in nonpassenger locations would prevent these serious noncrash injuries. (<i>JAMA</i>1985;253:2530-2533)
Percutaneous transluminal angioplasty for the treatment of renovascular hypertension
Authors: C. J. Tegtmeyer
Journal: JAMA (1981)

PHARMACOTHERAPY and surgical revascularization are the two treatment modalities widely available for the management of renovascular hypertension. Both methods of treatment are successfully used in the treatment of renovascular disease in selected patients, but neither method is ideal. A third method of treating renovascular disease, percutaneous transluminal angioplasty (PTA), is presently undergoing extensive evaluation. Percutaneous transluminal angioplasty was developed originally for the treatment of atherosclerotic peripheral vascular disease.<sup>1</sup>The development of the soft, flexible, doublelumen Grüntzig balloon catheter,<sup>2</sup>however, has allowed the procedure to be applied to the renal arteries. Renovascular hypertension caused by atherosclerotic narrowing of the renal arteries has been successfully treated.<sup>3,4</sup>Furthermore, the technique has been utilized successfully to treat patients with renovascular hypertension secondary to fibromuscular dysplasia.<sup>5-7</sup> The techniques, results, and versatility of PTA of renal arteries are described. <h3>Report of Cases</h3><h3>Case 1.—</h3> A 24-year-old woman was admitted with a two-year
LATENT SYPHILIS.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Report on the Biliary Secretion of the Dog: With Reference to the Action of Cholagogues
Authors: W. Rutherford
Journal: BMJ (1878)

THE well-known astringent effect of lead-acetate in cases of diarrhoea renders it desirable to know whether or not it ham the power of dimi- nishing the secretion of bile.R6brig.("ExperimeateeUnteisuchAngen