tbuckley/cabot-search huggingface dataset:
RAILROAD NOTICE.
Journal: JAMA (1884)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Primary outcome results of NSABP B-32, a randomized phase III clinical trial to compare sentinel node resection (SNR) to conventional axillary dissection (AD) in clinically node-negative breast cancer patients.
Authors: D. N. Krag, S. J. Anderson, T. B. Julian, A. Brown, S. P. Harlow, J. P. Costantino, T. Ashikaga, D. Weaver, E. P. Mamounas, N. Wolmark
Journal: Journal of Clinical Oncology (2010)

LBA505 Background: NSABP B-32 is the largest prospective randomized phase III trial designed to determine in SN negative patients that SNR alone results in the same survival and regional control as SNR + AD while reducing morbidity. It was designed to detect a survival difference of 2% between the 2 groups at 5 years. Methods: 5,611 women with operable, clinically N0, invasive breast cancer were randomized to SNR + AD (Group 1) or to SNR alone with AD only if SNs were positive (Group 2). 3,989 (71.1%) of the 5,611 patients were SN negative and followed for events. 99.9% of these SN negative patients had follow-up information: 1,975 in Group 1 and 2,011 in Group 2. Median time on study was 95.3 months. Patients were well balanced across clinical strata. Log-rank tests for unadjusted analyses and Cox proportional hazard models adjusting for study stratification variables were used to compare overall survival (OS) and disease-free survival (DFS) between the two groups. Two-sided p-values were used. HR values &gt; 1 indicate a more favorable outcome in Group 1 (SNR + AD). Results: Comparisons of OS (Group 1 vs. Group 2) yielded an unadjusted HR of 1.20 (p = 0.12) and an adjusted HR of 1.19 (p=0.13). Five-year Kaplan-Meier estimates for OS are 96.4% in Group 1 and 95.0% in Group 2 and the 8-year estimates are 91.8% and 90.3%, respectively. Comparisons of DFS (Group 1 vs. Group 2) yielded an unadjusted HR of 1.05 (p=0.54) and an adjusted HR of1.07 (p=0.57). No substantial differences could be seen across sites for first treatment failure. Five-year Kaplan-Meier estimates for DFS are 89.0% in Group 1, and 88.6% in Group 2 and the 8-year estimates are 82.4% and 81.5%, respectively. Local and Regional Recurrences: There were 54 local recurrences in Group 1 and 49 in Group 2 (p=0.55). There were 8 regional node recurrences as first events in Group 1 and 14 in Group 2 (p=0.22). Conclusions: No significant differences were observed in OS, DFS, or regional control between the trial groups. Within the limits of this trial, SNR without AD is validated as a safe and effective method for regional node treatment of SN negative breast cancer patients. [Table: see text]
MEDICAL PROGRESS.
Journal: JAMA (1889)

<h3>Surgical Tuberculosis.</h3> —In a series of lectures recently delivered byMr. Howard Marshat the Royal College of Surgeons of England, he gives the results of his own experience in the treatment of this disease: As regards the general group of tubercular diseases met with in surgery, when they are detected early and are adequately treated by prolonged rest, in not more than 10 per cent, do they develop to any formidable degree. It is a rule with but few exceptions in the lecturer's experience that when, for example, a knee or an elbow, which is the seat of tubercular disease of less than three months' duration, is enclosed in well-fitted splints and is kept at rest, the case gives no further real trouble, and improvement, though slow, goes on until the joint is apparently free from disease, while after a longer period of rest complete recovery is secured. The
Journal of Clinical Investigation, Boston
Journal: JAMA (1966)

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Abstracts
Journal: Annals of the Rheumatic Diseases (1967)

certain criteria were formulated by the authors with the object of gauging the potential danger of rheumatic fever developing in any Group-A streptococcal epidemic occurring in populations at risk so that mass prophylaxis could be instituted in time to abort the epidemic.The criteria were based on the finding of an index case of rheumatic fever and then the application of the following principles:(1) A Group-A prevalence rate of 30 per cent.or more, (2) A preponderance (50 per cent.or more) of typable strains,(3) At least one-third of the typable strains must be represented by one particular strain.In the spring of 1961, an epidemic of streptococcal infection associated with a high incidence of rheumatic fever occurred among schoolchildren in Dickinson, North Dakota, and was found to yield all these criteria; mass prophylaxis was instituted, with the result that the epidemic was aborted (
The role of emotional stress in the development of heart disease
Authors: J. C. Buell
Journal: JAMA (1979)

CURRENT interest in the relationship between emotional stress and cardiovascular disease stems from several observations. First, traditional risk factors are absent in more than half of the newly encountered cases of coronary heart disease. This observation suggests that other as yet unrecognized risk factors contribute to the pathogenesis of coronary heart disease. Second, there is impressive evidence that psychosocial conflict, emotions, and patterns of behavior can and do play an important role in the pathogenesis of certain types of cardiovascular disease. For example, using animals, investigators have been able to induce and document a variety of disease entities, including sustained hypertension, renal failure, accelerated atherosclerosis, coronary insufficiency, myocardial infarction, cardiomyopathy, and sudden death. However, whereas animal studies are easily controlled, comparably objective and controlled studies in man remain uncommon. At the present time, conclusions drawn from clinical research are more often supported by guilt through association and inference. The field
LONDON
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effects of Nonionizing Radiation on the Central Nervous System, Behavior, and Blood: A Progress Report
Authors: D. I. McRee, J. A. Elder, M. I. Gage, L. W. Reiter, L. S. Rosenstein, M. L. Shore, W. D. Galloway, W. R. Adey, A. W. Guy
Journal: Environmental Health Perspectives (1979)
Frozen Sections
Authors: T. J. Deeley, I. Burn
Journal: BMJ (1967)

Flow diversion for the management of intracranial aneurysms represents a paradigm shift in how aneurysms are managed. The Pipeline embolization device (PED) is, to date, the only flow diverter approved for use in the USA by the Food and Drug Administration. Limitations and complications with new treatment strategies are inevitable, and with the PED there have been reports of complications, most commonly with challenging deployments. Once deployment has been initiated, the device is ‘one-way’; it can only be deployed further or removed. Yet, situations arise in which the ability to recapture or reposition the device would be advantageous. A second-generation Pipeline has been developed that addresses these concerns. We report the first use in North America of this second-generation Pipeline device: the Pipeline Flex. We discuss our rationale for using the device, our impressions of its operation, and the relevant literature concerning the current state of flow diversion.
AB0208 Immune complex formation after exposure of autoantigens on the surface of secondary necrotic cells (SNEC) promotes inflammation in SLE
Authors: L.E. Munoz, C. Janko, S. Franz, S. Siebig, J. van der Vlag, G. Schett, M. Herrmann
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Systemic Lupus Erythematosus (SLE) is a chronic inflammatory disease characterised by the production of autoantibodies, formation of immune complexes (IC), and activation of complement.[1] Accumulation in blood and tissues of post-apoptotic remnants is considered of etiological and pathological importance for patients with SLE.[2, 3] <h3>Objectives</h3> The goal of this work is to analyse the phenotype of non-cleared remnants of apoptotic cells are to test if this phenotype contributes to the induction of inflammatory responses in SLE. <h3>Methods</h3> SNEC were generated by UVB irradiation of human lymphocytes followed by incubation for 48 hours. We employed fluorescence microscopy, FACS, and an <i>ex vivo</i> phagocytosis assays to demonstrate the availability of autoantigens on the surface of SNEC to form immune complexes that provoke inflammation. <h3>Results</h3> We describe the exposure of dsDNA on the surface of SNEC and the binding of serum opsonins to the surface of SNEC. We show that anti-dsDNA and other autoantibodies bind and sensitise SNEC. Autoantibody-sensitised SNEC were cleared by macrophages <i>in vitro</i> and induced a pro-inflammatory cytokine response. <h3>Conclusions</h3> Lupus autoantigens are exposed on the surface of SNEC and available to assemble intricate immune complexes with various autoantibodies. The clearance of cellular remnants that are not properly removed from the organism is targeted by lupus autoantibodies causing systemic inflammation in some patients with SLE. <h3>References</h3> Hahn, BH, Overview of pathogenesis of Systemic Lupus Erythematosus, in: Dubois’ Lupus Erythematosus, D.J. Wallace and B.H. Hahn, Editors. 2007, Lippincott Williams &amp; Wilkins: Philadelphia. p. 1414. Munoz, LE, Janko, C, Grossmayer, GE, Frey, B, Voll, RE, Kern, P, Kalden, JR, Schett, G, Fietkau, R, Herrmann, M, and Gaipl, US, Remnants of secondarily necrotic cells fuel inflammation in systemic lupus erythematosus. Arthritis Rheum 2009;60:1733-42. Munoz, LE, Lauber, K, Schiller, M, Manfredi, AA, and Herrmann, M, The role of defective clearance of apoptotic cells in systemic autoimmunity. Nat Rev Rheumatol 2010;6:280-9. <h3>Disclosure of Interest</h3> None Declared
New England Journal of Medicine, Boston
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Angiotensin-converting enzyme inhibitor and angiotensin receptor blocker use and outcomes in patients with colorectal cancer.
Authors: Sherilyn Alvaran Tuazon, Gentry Teng King, Joanna Sta. Cruz, Young K. Chae, Jean B. Ong Kian Koc, Sarah Hegarty, John Charles Leighton
Journal: Journal of Clinical Oncology (2014)

e14516 Background: Increasing evidence implicates angiotensin in the pathophysiology of carcinogenesis. Both Angiotensin Converting Enzyme Inhibitors (ACEIs) and Angiotensin Receptor Blockers (ARBs) have shown in-vitro activity in Colorectal Cancer (CRC) via inhibition of both VEGF and IGF-1, and present a novel therapeutic strategy. This study aimed to investigate the association of these agents in outcomes of patients with CRC. Methods: We reviewed the medical records of patients with stage I-III CRC from January 2004 to December 2008. ACEI and ARB use was defined as consumption for at least 3 months in patients with no evidence of disease after initial diagnosis and treatment. Outcomes were Disease Free Survival (DFS) and Overall Survival (OS). Kaplan-Meier and Cox proportional hazards regression were used. Results: A total of 222 patients were included, with a median follow up of 39 months. A total of 105 (47%) were identified as users of ACEI/ARBs. Multivariate analysis, adjusted to age, sex, race, stage, grade, tumor location, adjuvant chemotherapy, radiotherapy, statin and ASA use showed significantly improved DFS among users of ACEI and/or ARBs compared to non-users (HR = 0.44, p = 0.003). Considered separately, users of ACEIs only and users of ARBs only had better DFS than non-users (HR = 0.43 and 0.53, respectively). Compared directly, users of ACEIs did not have significantly different DFS than users of ARBs (HR = 0.81, p = 0.678). With regards to OS, multivariate analysis showed that, compared to non-users, patients with ACEI or ARB use had better OS, although non-significantly (HR = 0.59, p = 0.219). However, the magnitude of the impact on OS was comparable to that seen for DFS. Conclusions: The use of ACEIs and/or ARBs was associated with improved disease-free survival in CRC patients. ACEI/ARB users also had better OS, although not statistically significant, possibly due to the study’s much lower power regarding OS (only 27 deaths versus 71 events for DFS).
MEMBRANOUS ENTERITIS.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Inhalationsschäden
Authors: Kurt Georg Hering
Journal: Thorax (2003)

Inhalationsschäden der Lunge können als Folge von berufs- und umweltbedingten Einwirkungen lungengängiger Schadstoffe entstehen. Abhängig von der Natur des Stoffes und vom Ort der Einwirkung führt die Inhalation von Fremdkörpern, Gasen, Dämpfen, Rauchen oder Stäuben zu sehr unterschiedlichen Folgeerscheinungen.
OUR CONSULTANTS, 1962-1963
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Retinal Detachment
Authors: Edward Okun
Journal: JAMA (1960)

RETINAL DETACHMENT refers to the separation of the rod and cone layer of the retina from the pigment epithelium, thus reopening the potential space of the embryonic optic vesicle. In a number of pathologic conditions, hemorrhagic, exudative, or serous fluid may find its way into this potential space and elevate the retina. These conditions include chorioretinitis, panophthalmitis, the various vascular retinopathies, and intraocular tumors. The retina may also be pulled loose by the organization of vitreous hemorrhages and exudates, and the contraction of pathologic vitreous membranes. The term secondary retinal detachment has been applied to these cases in which the etiology is quite apparent, and the term idiopathic retinal detachment has been reserved for those cases in which the etiology remains more obscure. A retinal break by definition is a circumscribed complete loss of the retinal layers which are derived from the inner wall of the optic cup, thus
Meetings of Medical Interest
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ILEOSTOMY CLUBS
Authors: William Z. Fradkin
Journal: JAMA (1952)

<h3>To the Editor:</h3> —The communication concerning an ileostomy club by A. S. Lyons in the Oct. 25 issue ofThe Journal, page 812, will, in my opinion, encourage more colectomies for chronic ulcerative colitis. This is psychotherapy in reverse. Instead of minimizing the handicap, such a proposal directs more attention to it by throwing the patient into an "ileostomy environment" so to speak. "Ileostomy friends" are not desirable contacts for ileostomy patients. Although such intentions may be laudable, I fear that this is an admission of failure of physicians to cope with the problems of chronic ulcerative colitis and demonstrates their impatience in the handling of this distressing disease. The ideal treatment of chronic ulcerative colitis is not colectomy and permanent ileostomy. The latter procedure is indicated only in the rare and severe complications of chronic ulcerative colitis. Let us not regard our failures as successes! A colectomy for chronic