tbuckley/cabot-search huggingface dataset:
Biological Monitoring of Exposure to 3-Chloro-4-Fluoroaniline by Determination of a Urinary Metabolite and a Hemoglobin Adduct
Authors: Pieter J. Boogaard, Gerard D. J. Beulink, Nico J. van Sittert
Journal: Environmental Health Perspectives (1994)

In two studies, involving 75 and 72 workers, potential exposure to 3-chloro-4-fluoroaniline (CFA) was biologically monitored by determination of its main urinary metabolite 2-amino-4-chloro-5-fluorophenol sulfate (CFA-S).As this method only allows the detection of recent exposure, analysis of CFA adducts bound to hemoglobin (Hb) was investigated as a method that allows biological monitoring of exposure to CFA over longer periods.The median CFA-S concentration in 67 samples from the first study was 0.14 pmole/g creatinine (range <0.05 -2.82) and in 201 samples from the second study 0.21 pmole/g creatinine (range <0.05 -6.05).In addition, urine samples, collected after shifts with supposed incidental exposure, slightly higher concentrations were measured: 0.27 pmole/g creatinine (range <0.05 -122; 18 samples) and 0.76 pmole/g creatinine (range <0.05 -18.5; 46 samples), respectively.The median Hb adduct concentration in 75 samples from the first study was 9 pmoles CFAIg Hb (range <5 -640) and in 46 samples from the second study 12 pmoles/g Hb (range 3 -24).In 24 blood samples collected after incidents, a median concentration of 13 pmoles CFA/g Hb (range <5 -52) was found.Urinary CFA-S and Hb adducts correlated well in samples collected shortly after incidental exposures.However, in 25% of the operators, no CFA-S was detected during routine biological monitoring while Hb adduct analysis showed clear evidence of exposure.This indicates that because of the stability of Hb adducts of CFA in blood, intermittent exposure to CFA is more reliably biologically moni- tored by determination of Hb adducts of CFA than by assessment of urinary CFA-S.-Environ Health Perspect 1 02(Suppl 6):23-25 (1994) Key words: 3-chloro-4-fluoroaniline, 2-amino-4-chloro-5-fluorophenol sulfate, aromatic amines/
Podophyllin Toxicity
Authors: ROBERT G. RATE
Journal: Annals of Internal Medicine (1979)

Letters and Corrections1 April 1979Podophyllin ToxicityROBERT G. RATE, M.D., JACQUES LECHE, R.PH., CAROL CHERVENAK, R.PH.ROBERT G. RATE, M.D.Search for more papers by this author, JACQUES LECHE, R.PH.Search for more papers by this author, CAROL CHERVENAK, R.PH.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-4-723_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Drs. Stoehr, Peterson, and Taylor in their paper in the September issue (1) warn of the potentially toxic and even fatal complications of local podophyllin therapy. We wish to reinforce their warning and add another case of bone marrow suppression and severe motor/sensory peripheral neuropathy resulting from the aggressive treatment of condyloma acuminata with local podophyllin application.A 20-year-old Navajo woman (157 cm, 55 kg) received local podophyllin treatment for large perineal condyloma acuminata on 22 May 1975. Due to a lack of water at her hogan, she could not wash off the resin, and she returned...References1. STOEHRPETERSONTAYLOR GAW: Systemic complications of local podophyllin therapy. Ann Intern Med 89:362-363, 1978 LinkGoogle Scholar2. DAWSONDUCKWORTHBERNHARDTYOUNG DJHJ: Giant condyloma and verrucous carcinoma of the genital area. Arch Pathol 79:225-231, 1965 MedlineGoogle Scholar3. ROWE R: How I treat condyloma acuminatum. Postgrad Med 47:229-230, 1970 CrossrefMedlineGoogle Scholar4. SWERDLOWSALVATI DE: Condyloma acuminatum. Dis Colon Rectum 14:226-231, 1971 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: U.S. Public Health Service Keams Canyon, AZ 86034 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAntitubulin Agents: Colchicine, Vinca Alkaloids, and PodophyllinAntitubulin Agents: Colchicine, Vinca Alkaloids, and PodophyllinBerberidaceae Juss.Role of the Clinical Laboratory in Detecting Plant PoisoningAcute necrotizing myopathy and podophyllin toxicity: report of a fatal caseToxicité systémique de la podophylline : a propos d'une ingestion accidentelle mortelle. Revue de la littératureEncephalopathy and neuropathy following ingestion of a Chinese herbal broth containing podophyllinHealth Hazards Associated with ExtractivesToxische OsteopathienToxische OsteopathienPodophyllum Toxicity: A Report of a Fatal Case and a Review of the Literature 1 April 1979Volume 90, Issue 4Page: 723-723KeywordsBone marrowPeripheral neuropathyToxicity Issue Published: 1 April 1979 PDF DownloadLoading ...
Sexual health
Authors: Anne Kirkengen, Magne Nylenna, Pétur Pétursson, Peter Pritchard
Journal: BMJ (2003)

Future consultationsClinical inertia in implementation of preventive medical guidelines should not necessarily be taken as a sign of low quality care.It is time to reconsider the extent to which specific, opportunistic initiatives to prevent disease among asymptomatic individuals should remain a core element of everyday consultations in Western medicine.It is certainly good medical practice to identify, emphasise, and support health promoting resources, 27 skills, and activities that have a logical link to the patient's reason for coming to see the doctor.Other opportunistic initiatives may also seem appropriate.Doctors could increase patient autonomy by inviting the patient to introduce a topic rather than using a computerised reminding system.An open ended invitation may be one way to proceed.For example, "It could be that you have been considering other things that might be good for your health?If there is something you would like to discuss, you are welcome.
Introducing medical students to survivorship care through an elective oncology summer program.
Authors: Ryan Patrick McKillip, Olwen Mary Hahn, Nanna Helen Sulai, Carol A. Rosenberg, Olufunmilayo I. Olopade, Vineet M Arora, Daniel William Golden
Journal: Journal of Clinical Oncology (2016)

12 Background: Advancing the quality of cancer care requires that physicians be trained in survivorship care. An oncology seminar series was designed and implemented for first year medical students to improve their knowledge of oncologic disciplines, including survivorship care, by educating them about these disciplines from both a research and clinical perspective. Methods: First year medical students (MS1s) at a single United States medical school were invited to participate in the Scholars in Oncology-Associated Research (SOAR) summer program, which included a series of 10 lectures to provide a general survey of how clinical care, basic sciences, and social sciences apply to oncology as a multidisciplinary specialty. Lectures included topics specific to cancer genetics, medical, surgical, and radiation oncology, hospice/palliative medicine, and survivorship care. The students also attended a multidisciplinary tumor board and had the opportunity to shadow a pharmacist, radiation therapist, or palliative care advanced practice nurse. Students completed self-assessments of their understanding of oncology and its related disciplines before and after SOAR. Likert-type scores were 1 = not at all, 2 = somewhat, 3 = moderately, 4 = quite, and 5 = extremely and are reported as median [interquartile range]. Results: Eighteen students successfully completed the SOAR program out of 21 that initially enrolled. 20 pre- and 14 post-assessments were completed. Student self-reported understanding of oncology as a clinical discipline (2[2-3] vs. 4[4-4] p &lt; .01) and as a research discipline (3[2-3] vs. 4[4-4] p &lt; .01) improved after SOAR. Student understanding of survivorship care as a clinical discipline (1[1-2] vs. 2.5 [1-4] p = .02) and as a research discipline (1[1-1] vs. 2[1-3] p &lt; .01) also improved. All students indicated they would be “quite” or “extremely” likely to recommend SOAR to future students. Conclusions: A structured didactic introduction to oncology, SOAR, was successfully piloted. MS1s report improved understanding of oncology and survivorship care as clinical and research disciplines. Future work will focus on expanding SOAR to a larger audience.
Detection of Medullary Thyroid Cancer by Calcitonin Assay in Families.
Authors: Charles E. Jackson
Journal: Annals of Internal Medicine (1972)

Meeting Abstracts1 May 1972Detection of Medullary Thyroid Cancer by Calcitonin Assay in Families.Charles E. Jackson, M.D., F.A.C.P., Armen H. Tashjian Jr., M.D., Melvin A. Block, M.D.Charles E. Jackson, M.D., F.A.C.P.Search for more papers by this author, Armen H. Tashjian Jr., M.D.Search for more papers by this author, Melvin A. Block, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-76-5-877_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRadioimmunoassay of calcitonin is a reliable and practical means for early detection of medullary thyroid cancer, often before any other procedure indicates its presence. Response of serum calcitonin to calcium infusion was utilized as a diagnostic procedure in 58 members of three families with medullary thyroid carcinoma. Elevated basal or calcium stimulated levels, or both, were obtained in 16 individuals in these families. All 13 who subsequently had surgery were found to have bilateral neoplasms, the extent correlating well with stimulated calcitonin levels. These studies served as the only indication for surgery in the seven patients without palpable lesions. The... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Charles E. Jackson, M.D., F.A.C.P.; Armen H. TashjianJr., M.D.; Melvin A. Block, M.D.Affiliations: Detroit, Mich., and Boston, Mass. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byChemistry of Pyrido[1,2-c] [1,3]oxazines, Pyrido[1,2-c][1,3]thiazines, Pyrido[1,2-c]pyrimidines, and Their Benzologs: Part II 1 May 1972Volume 76, Issue 5Page: 877-877KeywordsCalcitoninCalciumLesionsMedullary thyroid carcinomaRadioimmunoassaysSurgeryThyroidThyroid carcinoma ePublished: 1 December 2008 Issue Published: 1 May 1972 PDF downloadLoading ...
Erratum: Vol 49, No. 29 (JAMA. 2000;284:953)
Journal: JAMA (2000)

SICKLE CELL DISEASE (SCD) IS A COMmon single-gene disorder that affects three of every 1000 black newborns and approximately 50,000 persons in the United States. 1 Children affected with SCD are at increased risk for severe morbidity (e.g., severe hemolytic anemia, splenic dysfunction, pain crises, and bacterial infections) and mortality, especially during the first 3 years of life. 1,2In 1993, California, Illinois, and New York collectively accounted for approximately 20% of all births to blacks.All three states offer universal newborn screening for hemoglobinopathies.To assess the effectiveness of newborn screening programs for SCD and for receipt of and compliance with early medical interventions (e.g., penicillin prophylaxis and pneumococcal vaccination and other vaccination patterns), a 3-year collaborative follow-up study was conducted from 1995 through 1998 in California, Illinois, and New York. 3This report summarizes the results of this study, which demonstrate the difficulty in retrospectively finding children who were screened at birth so that data for evaluating program effectiveness can be assessed.The study comprised children born in 1992 and 1993 and in whom SCD was diagnosed during 1992-1993.Follow-up information about these children was ascertained through complementary surveys administered to parents and physicians of affected children.State health departments administered physician surveys, which were mailed to the child's last known provider.Parental sur-veys were administered by Battelle/ Survey Research Associates, Inc., which conducted telephone interviews and, along with the respective health departments, made repeated attempts to locate the children.During 1992-1993, SCD was diagnosed in 1042 children in California (265 cases), Illinois (254), and New York (523).Fourteen children (six in California, three in Illinois, and five in New York) died before the study began.Completed physician surveys were returned for 752 (72%) of the children (144 in California, 254 in Illinois, and 354 in New York).Parental surveys were completed for 252 (24%) children (87 in California, 52 in Illinois, and 113 in New York).When data from both surveys were merged, physician and parental surveys were completed for 184 (18%) children.Among physician respondents, 575 (76%) reported providing antibiotic (penicillin) prophylaxis to their SCD patients; 253 (44%) patients complied with the prophylaxis antibiotic regimen.One hundred eighty-nine (25%) patients received pneumococcal vaccine, and 179 (24%) received at least the first dose of Haemophilus influenzae type b vaccine (Hib).
Instructions to Authors
Authors: David Cohen
Journal: Hepatology (2018)

Observations in Hepatology submissions are intended to be outstanding case-based contributions which describe a unique presentation, novel observation, or cutting edge approach to management of a liver disease.The format should not include an abstract.It should include a brief introduction, presentation of the case (or case series), and discussion.The maximum length is 750 words, including the summary and references.There is a maximum of 2 figures or tables, and 5 references.
Bacteremia associated with angiography
Authors: T. H. Shawker
Journal: JAMA (1974)

Positive bacterial cultures were obtained from catheters and guide wires or blood, or both, during 23 of 100 angiographic procedures. Most frequently contaminated were the catheters. In 11 cases, the organisms isolated were of low virulence (diphtheroids, coagulase-negative staphylococci, and an aerobic Gram-positive rod) and may have represented air or skin contaminants. In 12 cases, however, Gram-negative bacilli of known pathogenicity were recovered. Transient bacteremia was demonstrated in four cases, but in none did local infection of puncture or cutdown sites, or prolonged bacteremia leading to sepsis develop. Postprocedure temperature elevations were not proved to be related to catheter-induced infection. (<i>JAMA</i>229:1090-1092, 1974)
Tratamento cirúrgico das moléstias mentais (leucotomía)
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
LEUKOCYTIC REACTIONS TO MORPHIN
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Smokeless Tobacco Use in the United States
Journal: JNCI Journal of the National Cancer Institute (1990)

Journal Article Smokeless Tobacco Use in the United States Get access JNCI: Journal of the National Cancer Institute, Volume 82, Issue 2, 17 January 1990, Page 164, https://doi.org/10.1093/jnci/82.2.164 Published: 17 January 1990
Chronic Pain
Authors: Tracy Hampton
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE CARE OF THE BABY'S EYES IN THE PERAMBULATOR.
Authors: MARY E. BALDWIN
Journal: JAMA (1897)

The matter to which I call your attention, the baby's eyes in the perambulator, is one epoch in the life of many children that seems absolutely to have been ignored. I say many children! The very poor are not luxuriating on wheels. They have a possible contact with mother earth, or with a pavement. Again they get the air on the hip of an older sister. Children born in the other extreme of worldly position are not so often in a baby cab. In the maternity, the nursery and in the school, the young eyes have received intelligent attention with preventive suggestion and remedial treatment. The first bright spring days are hailed by invalids and almost anybody's baby is then given a breath in the fresh air. The invalid is apt to have a veil, colored glasses, a close carriage, a sunshade, etc. For this outing the baby of fairly
Laryngocele. Radiological diagnosis
Authors: K. R. Kattan
Journal: JAMA (1980)

LARYNGOCELE is an abnormal saccular dilation and elongation of the appendix of the laryngeal ventricle of Morgagni (Fig 1). The term laryngocele was introduced by Virchow in 1867.<sup>1</sup>The laryngeal ventricle is a small elliptical recess between the false and the true vocal cords. Anteriorly it ends in a blind pouch known as the laryngeal appendix. This pouch varies in length, and if it extends above the upper border of the thyroid cartilage it is considered abnormal.<sup>2</sup>This appendix is present at birth and is relatively large. It begins to regress by the end of the sixth year. Though laryngoceles are uncommonly reported, they are not rare and occur more than the literature indicates.<sup>3</sup>Some examples are presented. Figure 2 is an anteroposterior roentgenogram of the neck of a 53-year-old man who complained of hoarseness of two months' duration. Before his admission he was given antibiotics, resulting
<i>QuickStats</i>: Percentage* of Adults with a Visit to a Health Professional in the Past 12 Months Who Received Dietary Advice,† by Obesity Status§ and Age Group — National Health Interview Survey,¶ United States, 2014
Journal: MMWR Morbidity and Mortality Weekly Report (2016)

Department of Health and Human Services/Centers for Disease Control and Prevention * With 95% confidence intervals indicated with error bars.† Based on the question, "During the last 12 months, has a doctor or other health professional talked to you about your diet?" § Obesity status was based on respondent-reported height and weight and calculated as body mass index (BMI) using the following formula: BMI = weight/height 2 (kg/m 2 ).An adult who was obese had a BMI ≥30; an adult who was not obese had a BMI <30.¶ Estimates are based on household interviews of a sample of the noninstitutionalized U.S. civilian population and were derived from the National Health Interview Survey Sample Adult component.
Highlights
Journal: JAMA Internal Medicine (2019)

Outcomes of Inpatient Echocardiography Use 1176Pack and colleagues performed this retrospective cohort study of data from a large multihospital database to evaluate the association between hospital rates of echocardiography use and outcomes in adult patients with acute myocardial infarction.Of 98 999 admissions for acute myocardial infarction among 397 US hospitals in 2014, higher hospital rates of echocardiography use were associated with longer length of stay and greater costs.However, no difference was found in rates of inpatient mortality or 3-month readmission. Overdose and Opioid Prescriptions to Family Members 1186This case-control study by Khan and colleagues used more than 25 million insurance claims to assess whether individuals who did not receive an opioid prescription had greater odds of overdose when an opioid prescription was dispensed to a family member.Individuals who experienced overdose were identified by their first opioid overdose after the baseline period and matched to control participants by time in the claims database, calendar time, age, sex, and number of individuals in the family unit.Results showed that prior opioid dispensing to family members was associated with 2.89-fold higher odds of individual overdose, which persisted in young children and increased with greater quantities of opioid medications dispensed to family members.