tbuckley/cabot-search huggingface dataset:
US Cystic Fibrosis Foundation and European Cystic Fibrosis Society consensus recommendations for the management of non-tuberculous mycobacteria in individuals with cystic fibrosis
Authors: R Andres Floto, Kenneth N Olivier, Lisa Saiman, Charles L Daley, Jean-Louis Herrmann, Jerry A Nick, Peadar G Noone, Diana Bilton, Paul Corris, Ronald L Gibson, Sarah E Hempstead, Karsten Koetz, Kathryn A Sabadosa, Isabelle Sermet-Gaudelus, Alan R Smyth, Jakko van Ingen, Richard J Wallace, Kevin L Winthrop, Bruce C Marshall, Charles S Haworth
Journal: Thorax (2015)

Non-tuberculous mycobacteria (NTM) are ubiquitous environmental organisms that can cause chronic pulmonary infection, particularly in individuals with pre-existing inflammatory lung disease such as cystic fibrosis (CF). Pulmonary disease caused by NTM has emerged as a major threat to the health of individuals with CF but remains difficult to diagnose and problematic to treat. In response to this challenge, the US Cystic Fibrosis Foundation (CFF) and the European Cystic Fibrosis Society (ECFS) convened an expert panel of specialists to develop consensus recommendations for the screening, investigation, diagnosis and management of NTM pulmonary disease in individuals with CF. Nineteen experts were invited to participate in the recommendation development process. Population, Intervention, Comparison, Outcome (PICO) methodology and systematic literature reviews were employed to inform draft recommendations. An anonymous voting process was used by the committee to reach consensus. All committee members were asked to rate each statement on a scale of: 0, completely disagree, to 9, completely agree; with 80% or more of scores between 7 and 9 being considered 'good' agreement. Additionally, the committee solicited feedback from the CF communities in the USA and Europe and considered the feedback in the development of the final recommendation statements. Three rounds of voting were conducted to achieve 80% consensus for each recommendation statement. Through this process, we have generated a series of pragmatic, evidence-based recommendations for the screening, investigation, diagnosis and treatment of NTM infection in individuals with CF as an initial step in optimising management for this challenging condition.
Estimating the Extent of the Health Hazard Posed by High-Production Volume Chemicals
Authors: Albert R. Cunningham, Herbert S. Rosenkranz
Journal: Environmental Health Perspectives (2001)

We used structure-activity relationship modeling to estimate the number of toxic chemicals among the high-production volume (HPV) group. We selected 200 chemicals from among the HPV chemical list and predicted the potential of each for its ability to induce a variety of adverse effects including genotoxicity, carcinogenicity, developmental, and systemic toxicity. We found a significantly less than expected proportion of toxic chemicals among the HPV sample when compared to a reference set of 10,000 chemicals representative of the universe of chemicals.
MISCELLANEA MEDICA
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Towards to gene knock out in activated Kupffer cells . Institute of Molecular Biology in Medicine, CUCS-University of Guadalajara, Mexico and VAMC, Memphis, TN
Journal: Hepatology (1995)

In this study, we investigate the effects of decision-related factors on recognition memory in pupil old/new paradigms. In Experiment 1, we used an old/new paradigm with words and pseudowords and participants made lexical decisions during recognition rather than old/new decisions. Importantly, participants were instructed to focus on the nonword-likeness of presented items, not their word-likeness. We obtained no old/new effects. In Experiment 2, participants discriminated old from new words and old from new pseudowords during recognition, and they did so as quickly as possible. We found old/new effects for both words and pseudowords. In Experiment 3, we used materials and an old/new design known to elicit a large number of incorrect responses. For false alarms (“old” response for new word), we found larger pupils than for correctly classified new items, starting at the point at which response execution was allowed (2750 ms post stimulus onset). In contrast, pupil size for misses (“new” response for old word) was statistically indistinguishable from pupil size in correct rejections. Taken together, our data suggest that pupil old/new effects result more from the intentional use of memory than from its automatic use.
US Military Medicine Responds to Results of Terrorism in Africa
Authors: P. Gunby
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
INFORMATION FOR AUTHORS: EDITORIAL POLICY
Journal: JNCI Journal of the National Cancer Institute (1990)

Journal Article INFORMATION FOR AUTHORS: EDITORIAL POLICY Get access JNCI: Journal of the National Cancer Institute, Volume 82, Issue 10, 16 May 1990, Pages 890–892, https://doi.org/10.1093/jnci/82.10.890 Published: 16 May 1990
Shifting Focus on a Shifting Curve
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Aerztliche Forschung, Munich
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Miscellany.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Update: Coccidioidomycosis—California, 1991-1993
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Association of the Dysbindin Gene With Bipolar Affective Disorder
Authors: Gerome Breen
Journal: American Journal of Psychiatry (2006)

Objective: In the study of bipolar affective disorder and schizophrenia, there is some evidence suggesting a phenotypic and genetic overlap between the two disorders. A possible link between bipolar affective disorder and schizophrenia remains arguable, however. The authors hypothesized that dysbindin, which is a probable susceptibility gene for schizophrenia, was associated with bipolar affective disorder and tested this hypothesis using a case-control design study. Method: Participants included 213 patients with bipolar I disorder and 197 comparison subjects. In each subject, 10 polymorphisms in the dysbindin gene were genotyped and assessed. Results: Two polymorphisms showed individual genotypic association with bipolar I disorder. Multiple marker haplotypes were more strongly associated, with the rarer of the two common haplotypes being overrepresented in the patients with bipolar affective disorder. A similar finding was reported in patients with schizophrenia in a previous study. Conclusions: Findings suggest that the human dysbindin gene may play a role in the susceptibility to bipolar affective disorder, which underscores a potentially important area of etiological overlap with schizophrenia. The existence of shared genetic risk factors will, in time, lead to changes in the current nosology of major psychoses.
Lettsomian Lectures on the Objects and Limits of Operations for Cancer: Delivered before the Medical Society of London, February, 1896
Authors: W. W. Cheyne
Journal: BMJ (1896)

AND GENTLEMEN,-In the first place, allow me to thank you for the high honouryou have done me in selecting me as your Lettsomian Lecturer on this occasion.While your selection has done me great honour and given me much pleasure it has also caused me great anxiety, more especially in the choice of a subject which would be of suffi- cient interest to the Fellows of the Society: for it seems to me that the great value of lectures of this kind is that they afford an opportunity, not so much of presenting original work, as of reviewing the present standpoint of medical science in some particular department, of criticising the advances that have been made, of seeing what of these advances are good and what are of doubtful value, and thus of furnishing a basis for further work.
Highlights
Journal: JAMA Dermatology (2018)

Pemphigus is a rare autoimmune blistering disease characterized by painful vesicobullae on the skin and mucous membranes.Parkinson disease (PD) has been significantly associated with pemphigus, and other neurologic disorders may be similarly associated.In this population-based cross-sectional study, Kridin et al demonstrate a 2-fold higher prevalence rate of dementia, epilepsy, and PD among patients with pemphigus than age-, sex-, and ethnicity-matched controls.Multiple sclerosis was not associated with pemphigus.Physicians who care for patients with pemphigus should be aware of this association, and patients with pemphigus should be carefully screened for comorbid disorders.Linder and colleagues provide the Editorial.
Individual patient level meta-analysis of the performance of the Decipher genomic classifier in high-risk men post-prostatectomy to predict development of metastatic disease.
Authors: Daniel Eidelberg Spratt, Kasra Yousefi, Samineh Deheshi, Ashley Ross, Edward M. Schaeffer, Bruce J. Trock, Jeffrey Karnes, Andrew Glass, Robert B. Den, Adam Dicker, Stephen J. Freedland, Lucia L.C. Lam, Marguerite du Plessis, Voleak Choeurng, Zaid Haddad, Christine Buerki, Elai Davicioni, Sheila Weinmann, Eric A. Klein, Felix Yi-Chung Feng
Journal: Journal of Clinical Oncology (2017)

133 Background: The genomic classifier, Decipher, has been validated to predict risk of metastasis after radical prostatectomy (RP). However, the cohort size and event rate in the previous studies did not allow for a thorough investigation into performance within individual clinicopathologic or treatment subgroups. In this study, we present the first meta-analysis of the performance of the 22-marker genomic classifier in men with prostate cancer (PCa) post-RP. Methods: MEDLINE, EMBASE, and the Decipher genomic resource information database were searched for published reports of men with PCa treated by RP between 2010 and 2016 where the benefit of the Decipher genomic classifier test was assessed. The primary end point was the ability of Decipher to independently improve prognostication of regional or distant metastasis over routine clinicopathologic factors. Meta-analysis was performed with random-effects modeling, and extent of heterogeneity between studies was determined with the I 2 test. Results: Five studies (975 total patients, and 855 with individual patient genomic and clinicopathologic data) were eligible for analysis. The median follow-up was 8 years. All patients had clinical high-risk disease, yet 60.9%, 22.6%, and 16.5% of patients were classified as low, intermediate, and high-risk, respectively by Decipher and had 10-year cumulative incidence rates of metastases of 5.5%, 15.0% and 26.7% (p &lt; 0.001), respectively. Adjusting for standard clinicopathologic variables, on multivariable analysis Decipher remained a statistically significant predictor of metastasis (hazard ratio [HR] 1.30 per 0.1 unit, 95% confidence interval [CI] 1.14-1.47, p &lt; 0.001), and the summary HR for metastasis of Decipher across the 5 studies was 1.52 (95% CI 1.39-1.67) per 0.1 unit. Conclusions: The genomic classifier test, Decipher, has the ability to independently improve prognostication of men post-RP, as well as within nearly all clinicopathologic and treatment subgroups. Strong consideration should be given to incorporating the use of genomic testing in clinical decision making and clinical trials to better individualize treatment.
Colon tumors and colonoscopy
Authors: S. Misra, M. Dwivedi
Journal: Endoscopy (2006)

The Digestive Disease Week (DDW) meeting held in Los Angeles in 2006 featured many abstracts on diverse colonoscopy topics, including the ease of cecal intubation; the detection and importance of treatment of diminutive colorectal polyps; and the role of submucosal dissection, with or without ligation, for colonic tumors, especially rectal carcinoids. Many studies aimed to clarify the role of high-resolution colonoscopy compared with magnifying colonoscopy, and the importance of narrow-band imaging and autofluorescence imaging in the detection and management of colonic tumors was also explored.
BBS volume 17 issue 1 Cover and Back matter
Authors: S Anstis, L Arend, H Barlow, M Fahle, D Hoffman, Chr Koch, J Koenderink, D Macleod, San Diego, H Mallot (tubingen, O Neumann (bielefeld, R Niederee (kiel, Chr Nothdurft, E Gottingen, V Poppel, San Ramachandran, E Diego, Oldenburg Scheerer, R Shepard, G Sperling, Dieter Heyer, Rainer Mausfeld, Robert Sternberg
Journal: Behavioral and Brain Sciences (1994)

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Abstract 1717: Post-Procedural Incomplete Stent Apposition after Implantation of Everolimus-Eluting or Paclitaxel-Eluting Stents: Insights from the Randomized SPIRIT III Trial
Authors: Masao Yamasaki, Junya Ako, Ichizo Tsujino, Ryota Sakurai, Katsuhisa Waseda, Takao Hasegawa, Takao Shimohama, Yasuhiro Honda, Alexandra J Lansky, Krishnankutty Sudhir, Gregg W Stone, Peter J Fitzgerald
Journal: Circulation (2007)

Background : We investigated the morphometric changes of post-procedural incomplete stent apposition (ISA) after implantation of Everolimus-eluting cobalt-chromium alloy XIENCE™ V stents (EES) and Paclitaxel-eluting Taxus ™ stents (PES). Methods : Data were obtained from the SPIRIT III trial (2:1 randomized, multicenter trial comparing EES to PES in de novo native coronary artery lesions). Serial IVUS imaging was performed post-intervention and at 8 months follow-up. ISA was defined as separation of at least 1 stent strut from the vessel wall with evidence of blood speckle behind the strut. The following parameters were obtained from the IVUS analysis: ISA area at the maximum ISA (max ISA) site, ISA angle (angle of the ISA arc at the max ISA site), ISA depth (length between the stent strut and the vessel wall at the max ISA site), and ISA length (longitudinal length of the ISA); vessel, stent, lumen, peri-stent plaque, and neointimal hyperplasia area at the ISA site. Results : At baseline, there were 34 ISA sites in 29 EES (18 at the proximal edge, 9 at the distal edge, and 7 within the stent body), and 16 ISA sites in 11 PES (4 at the proximal edge, 5 at the distal edge, and 7 within the stent body). ISA area, angle, depth, and length decreased between post-procedure and follow-up period in both groups (Table ). Vessel and peri-stent plaque area increased in PES, whereas no changes were observed in EES. There was no difference in the incidence of either persistent or resolved ISA between the 2 groups (p=0.32). Neither stent thrombosis nor in-stent restenosis occurred in the patients with post-procedural ISA over a period of 12 months. Conclusion : This IVUS analysis suggests different vessel responses at the site of post-procedural ISA between EES and PES, but no clinical consequences. Longer term follow-up with larger cohorts is warranted to further validate the clinical implications of ISA with drug-eluting stents.
Hypertension. A strange case of neglect
Authors: I. H. Page
Journal: JAMA (1976)

IT IS a common characteristic of physicians, artists, and scientists to believe that their own special interests are neglected. No writer ever receives enough praise for his book; no artist is happy with a brief review, and no physician thinks his specialty is given the high place in the pecking order that it is due. In my youth, hypertension was considered a good thing—well, good at least in that it perfused adequate amounts of blood through thickened arteries, especially those in the kidneys. Lowering blood pressure could only lead to ischemia of the kidneys and uremia. Hypertension was believed divisible into two classes: fixed (irreversible) and labile (reversible). Two very convenient beliefs indeed, since no one knew how to lower blood pressure of the "reversible" variety, and "irreversible" meant just that. In the early '30s, there was a general feeling among the newly self-styled cardiologists that hypertension must be more