tbuckley/cabot-search huggingface dataset:
Randomised trial of endoscopy with testing for Helicobacter pylori compared with non-invasive H pylori testing alone in the management of dyspepsia
Journal: BMJ (2002)

Most doctors were against drinking any alcohol while on call (table), but 14% felt that social drinking was acceptable, and one fourth thought that in their specialty some alcohol use is safe.In response to asking how many drinks a doctor in their specialty could safely drink while on call, 94/129 (73%) answered 0, 12/129 (9%) answered 1, 5/129 (4%) answered 2, 6/129 (5%) answered 3, and 13/129 (10%) answered 4 or more.A quarter admitted to drinking alcohol while on call, and 64% and 27% reported having encountered colleagues whom they suspected had used or were impaired by alcohol while on call, respectively.Almost all doctors believed that patients care whether they use alcohol while on call, but doctors were divided about their obligation to inform patients before seeing them.Multivariable analysis showed that sex and specialty were not associated with doctors' responses.Older doctors, however, were more likely to report encountering doctors whom they suspected had used or were impaired by alcohol while on call.
Erratum for Euro Surveill. 2018;23(6)
Journal: Eurosurveillance (2018)

© This work is licensed under a Creative Commons Attribution 4.0 International License. Closure This is a corrected article applying to the following content: Multiplex PCR for detection of plasmid-mediated colistin resistance determinants, mcr-1, mcr-2, mcr-3, mcr-4 and mcr-5 for surveillance purposes
CORRECTION
Journal: Circulation (1951)

In the article entitled "A-V Conduction in Auriclar Flutter" by M. Besoain-Santacnder, A. Pick, and R. Langendorf (Circulation 2:604, 1950), it was not clearly stated that Dr. M. Besoain-Santander was a Fellow of the Division of International Health of the U. S. Public Health Service.
Aflatoxin B1 DNA adducts in smeared tumor tissue from patients with hepatocellular carcinoma
Authors: C Chen
Journal: Hepatology (1992)

Aflatoxins are well-known animal hepatocarcinogens, but the association between aflatoxins and human hepatocellular carcinoma remains to be elucidated. A study method consisting of indirect immunofluorescence assay combined with densitometry was developed to quantitate aflatoxin B1 DNA adducts in smeared liver tissue obtained at the time of biopsy for diagnosis in 50 hepatocellular carcinoma patients in Taiwan. Monoclonal antibody 6A10, generated against the persistent form of the major N7 guanine adduct of aflatoxin B1, was used for detection of adduct. Thirty-five (70%) of the hepatocellular carcinoma samples had detectable levels of aflatoxin B1 DNA adducts (⩾ 1/106 nucleotides). The detection rate was slightly lower in men (69%) than in women (75%), and younger patients had a significantly higher rate of adducts (83%) than did older ones (58%). Carriers of both HBsAg and HBeAg, carriers of HBsAg only and noncarriers had different rates of detection: 29%, 74% and 82%, respectively. Patients with family histories of hepatocellular carcinoma had a higher detection rate (100%) than did those patients without such histories (67%). No association was found between aflatoxin B1 DNA adducts in liver tissue and Child's score for severity of liver disease. The results suggest that aflatoxin B1 may be involved in the pathogenesis of hepatocellular carcinoma in Taiwan. Our immunohistochemical method for analysis of adducts in small numbers of cells from the target organ should improve results of monitoring for the biologically effective dose of aflatoxin. HEPATOLOGY 1992;16:1150–1155.
Processing pictures with computers. An introduction
Authors: R. D. Yoder
Journal: JAMA (1967)

Most persons, perhaps, think of computers as devices which write pay checks or calculate satellite orbits. Although the processing of pictorial information promises dramatic and significant contributions to the health sciences and many other fields, it is only in connection with recent deep space probes that most persons have heard the words "computer" and "picture" used together. This discussion will concern the use of computers to detect characteristics and measure specific parameters in pictures. These measurements may then be analyzed, to produce "answers" in the form of conventional probabilistic statistics, such as the likelihood of occurence by chance. Far more complex taxonomic methods<sup>1</sup>are being developed and may be expected to be of importance in the future. However, these usually require extensive use of prediagnosed material in order to "teach" the program the characteristics of desired concepts such as "normal" or "abnormal." Although in the future we envision widespread
Family Focused Grief Therapy: A Randomized, Controlled Trial in Palliative Care and Bereavement
Authors: David W Kissane, Maria McKenzie, Sidney Bloch, Chaya Moskowitz, Dean P McKenzie, Imogen O'Neill
Journal: American Journal of Psychiatry (2006)

The aim of family focused grief therapy is to reduce the morbid effects of grief among families at risk of poor psychosocial outcome. It commences during palliative care of terminally ill patients and continues into bereavement. The authors report a randomized, controlled trial.Using the Family Relationships Index, the authors screened 257 families of patients dying from cancer: 183 (71%) were at risk, and 81 of those (44%) participated in the trial. They were randomly assigned (in a 2:1 ratio) to family focused grief therapy (53 families, 233 individuals) or a control condition (28 families, 130 individuals). Assessments occurred at baseline and 6 and 13 months after the patient's death. The primary outcome measures were the Brief Symptom Inventory, Beck Depression Inventory, and Social Adjustment Scale. The Family Assessment Device was a secondary outcome measure. Analyses allowed for correlated family data and employed generalized estimating equations based on intention to treat and controlling for site.The overall impact of family focused grief therapy was modest, with a reduction in distress at 13 months. Significant improvements in distress and depression occurred among individuals with high baseline scores on the Brief Symptom Inventory and Beck Depression Inventory. Global family functioning did not change. Sullen families and those with intermediate functioning tended to improve overall, whereas depression was unchanged in hostile families.Family focused grief therapy has the potential to prevent pathological grief. Benefit is clear for intermediate and sullen families. Care is needed to avoid increasing conflict in hostile families.
Medical rehousing.
Authors: E L Howells
Journal: BMJ (1984)

A local authority and its medical adviser collaborated to assess the needs of applicants who have special requirements for medical rehousing. Some characteristics of the applicants were examined, together with how successfully their needs were met. Over half the applicants were aged over 55. Some three years after their initial application 41% of applicants considered to have medical priority had been rehoused compared with 36% of those with no medical priority.
Contents
Authors: C.-Y Park, S.-H Choi, S.-M Kang, J.-I Kang, B.-Y Ahn, H Kim, T Reiberger, B Angermayr, P Schwabl, N Rohr-Udilova, L Van Wagner, T Baker, S Ahya, J Norvell, E Wang, J Levitsky
Journal: Journal of Hepatology (2009)
Total distal penile necrosis caused by condom catheter
Authors: G. Steinhardt
Journal: JAMA (1980)

RECOGNITION of the long-term sequelae of indwelling urethral catheters has led to the increasing use of condom catheter drainage systems in paraplegic and geriatric populations. We present a case of penile necrosis caused by condom catheter and submit recommendations for the care of condom catheter systems. <h3>Report of a Case</h3> An 86-year-old man was discharged from an outlying hospital after recovering from a stroke that resulted in a left-sided hemiparesis. Because of unpredictable voiding, a condom catheter was applied before his discharge from that hospital. The patient was sent home under the care of his wife and daughter. Four days after discharge, the patient was brought to our emergency room because the end of his penis had turned black (Figure). The patient's family had not changed his condom catheter; they had received no instructions regarding its care. A punch cystostomy was performed to divert the urinary stream, and, after appropriate
PDIGREE: An adaptive phase III trial of PD-inhibitor nivolumab and ipilimumab (IPI-NIVO) with VEGF TKI cabozantinib (CABO) in metastatic untreated renal cell cancer (Alliance A031704).
Authors: Tian Zhang, Karla V. Ballman, Atish Dipankar Choudhury, Ronald C. Chen, Colleen Watt, Yujia Wen, Ardaman Shergill, Tyler J. Zemla, Hamid Emamekhoo, Ulka N. Vaishampayan, Michael J. Morris, Daniel J. George, Toni K. Choueiri
Journal: Journal of Clinical Oncology (2020)

TPS5100 Background: First-line treatment of mRCC has rapidly changed to include IPI-NIVO or CABO, with clinical benefit of each based on the Checkmate 214 and CABOSUN (A031203) trials. Combination immunotherapy with VEGF therapies has shown benefit over sunitinib in the JAVELIN 101 and KEYNOTE 426 trials. It is yet unclear which patients (pts) benefit most from combination immunotherapy-VEGF inhibitors, and the optimal sequence of drugs. Methods: In an adaptive, randomized, multicenter phase 3 trial (Alliance A031704, PDIGREE), pts start treatment with induction IPI 1 mg/kg and NIVO 3 mg/kg intravenously (IV) once every 3 weeks. Key inclusion criteria include clear cell mRCC, International Metastatic RCC Database Consortium (IMDC) intermediate or poor risk, Karnofsky performance status &gt; 70, and no prior treatments for mRCC. Based on 3-month radiographic assessment (after completing IPI-NIVO combination), pts with complete responses (CR) undergo maintenance NIVO 480 mg IV every 4 weeks; pts with progression of disease (PD) switch to CABO 60 mg oral daily; pts with non-CR/non-PD are randomized to NIVO 480 mg IV every 4 weeks versus NIVO 480 mg IV every 4 weeks with CABO 40 mg oral daily. Randomization is stratified by IMDC risk criteria and presence of bone metastases. The primary endpoint of the study is overall survival (OS). We hypothesize that 3-year OS will improve to 70% for NIVO-CABO compared to 60% for NIVO alone; to achieve 85% power with a two-sided alpha of 0.05 and exponential distribution, 696 patients will be randomized. Accounting for 30% patients with either CR or PD, and 5% dropout from toxicity, up to 1046 pts will be enrolled. Key secondary endpoints include progression-free survival, 12-month CR rate, overall response rate based on RECIST 1.1 and irRECIST criteria, and toxicity profiles. Quality of life will be assessed based on the FKSI-19, PROMIS-fatigue, and EQ5D-5L questionnaires. Biomarkers associated with CR, tissue-based and plasma-based biomarkers will be assessed. Updated enrollment through May 2020 will be presented. Clinical trial information: NCT03793166 .
Notices
Authors: Seymour Sabesin
Journal: Hepatology (1991)

Sponsored by the American College of Physicians and Rush-Presbyterian-St. Luke's Medical Center, Chicago, the course will emphasize how basic physiology, biochemistry, pathophysiology and histopathology can be used to assist the physician in understanding, evaluating and treating patients with gastrointestinal and hepatobiliary diseases.The mechanisms of disease will be considered from a clinical and pathological perspective with emphasis on clinical assessment, differential diagnosis, interpretation and usefulness of gastrointestinal and liver biopsies, usefulness and cost-effectiveness of various radiological imaging techniques, endoscopic procedures and other laboratory tests.
Goblet Cell Carcinoids: Characteristics of a Danish Cohort of 83 Patients
Authors: I.H. Olsen, N. Holt, S. Langer, J. Hasselby, H. Grønbæk, J. Hillingsø, M. Mahmoud, M. Ladekarl, L. Iversen, A. Kjær, B. Federspiel, U. Knigge
Journal: Annals of Oncology (2014)
RESULTS OF TESTS IN HAY-FEVER AND ASTHMA
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effects of glucose on hepatic conversion of aminonitrogen to urea in patients with cirrhosis: Relationship to glucagon
Authors: O Hamberg
Journal: Hepatology (1994)

Glucose reduces the hepatic conversion of aminonitrogen to urea, quantified by the functional hepatic nitrogen clearance (i.e., the slope of the linear relation between urea synthesis rate and blood α-aminonitrogen concentration). This is due to a direct effect of glucose and to inhibition of glucagon. In this study, the effect of glucose on functional hepatic nitrogen clearance was examined during spontaneous hormone responses and during hormonal control by somatostatin. In 7 control subjects (study 1) and 9 patients with cirrhosis (study 2), functional hepatic nitrogen clearance was assessed twice in each subject: during infusion of alanine and during alanine administration superimposed on a continuous glucose infusion (blood glucose, on average = 8.4 mmol/L). In study 3, 6 patients with cirrhosis had functional hepatic nitrogen clearance determined on three occasions: during infusions of alanine and of alanine superimposed on infusion of somatostatin with either euglycemia or hyperglycemia (blood glucose = 8.4 mmol/L). In the control subjects (study 1), functional hepatic nitrogen clearance was 32.5 ± 1.9 L/hr, and glucose reduced it to 18.4 ± 0.9 L/hr (p < 0.01). In the cirrhotic patients, functional hepatic nitrogen clearance was only 9.8 ± 1.3 L/hr (p < 0.01 vs. controls), and glucose did not change it. In the control subjects, glucose reduced the glucagon response to alanine from 204 ± 36 ng/L to 106 ± 8 ng/L (p < 0.05). In the cirrhotic patients the mean fasting glucagon level was increased twofold (180 ± 21 ng/L). The response to alanine increased to 968 ± 265 ng/L; it was not reduced by glucose. In study 3, somatostatin and hyperglycemia reduced functional hepatic nitrogen clearance from 13.2 ± 1.5 L/hr to 6.4 ± 0.7 L/hr (p < 0.01). Somatostatin and euglycemia reduced functional hepatic nitrogen clearance to 9.2 ± 1.2 L/hr (p < 0.01 vs. alanine and hyperglycemia). The results show that the reduction by glucose of hepatic aminonitrogen conversion is lost in cirrhotic patients. The markedly increased glucagon response to alanine was not suppressed by glucose. Inhibition of the glucagon response by somatostatin reestablished the glucose effect, which was in part due to inhibition of glucagon in itself. Thus hepatic aminonitrogen conversion in cirrhosis depends on increased glucagon levels. The hormone-independent effect of glucose is preserved if the hyperglucagonemia is abolished, but the spontaneous high glucagon level overrules the glucose effect. The results indicate reduced hepatic contribution to the nitrogen-sparing effect of glucose in cirrhotic patients. (Hepatology 1994;19:45–54).
Update: West Nile Virus Activity--Eastern United States, 2000
Journal: JAMA (2000)

Data reported to CDC through the West Nile Virus (WNV) Surveillance System have shown an increase in the geographic range of WNV activity in 2000 compared with 1999, the first year that WNV was reported in the Western Hemisphere. In response to this occurrence of WNV, 17 states along the Atlantic and Gulf coasts, New York City, and the District of Columbia conducted WNV surveillance, which included monitoring mosquitoes, sentinel chicken flocks, wild birds, and potentially susceptible mammals (e.g., horses and humans). In 1999, WNV was detected in four states (Connecticut, Maryland, New Jersey, and New York) . In 2000, epizootic activity in birds and/or mosquitoes was reported from 12 states (Connecticut, Delaware, Maryland, Massachusetts, New Hampshire, New Jersey, New York, North Carolina, Pennsylvania, Rhode Island, Vermont, and Virginia) and the District of Columbia. Of the 13 jurisdictions, seven also reported severe neurologic WNV infections in humans, horses, and/or other mammal species. This report presents surveillance data reported to CDC from January 1 through November 15.
The dilemma of 'mild' hypertension. Another viewpoint of treatment
Authors: R. W. Gifford
Journal: JAMA (1983)

THE ISSUE of whether to treat "mild" hypertension is more controversial than the two articles<sup>1,2</sup>and one editorial<sup>3</sup>that were published in the Jan 21 issue of<i>JAMA</i>would lead the unsuspecting reader to believe. There are many who believe that the evidence favors the use of drug therapy to reduce diastolic BP when it is consistently above 90 mm Hg despite a three- to six-month trial of appropriate nonpharmacologic (eg, dietary) treatment. This issue is not an inconsequential academic controversy. The lives and well-being of more than 20 million Americans with mild hypertension are at risk. The Hypertension Detection and Follow-up Program (HDFP) data indicate that rigorous treatment of mild hypertension decreases the five-year mortality by 20.3% (from 7.4% in the referred care [RC] group to 5.9% in the stepped care [SC] group [<i>P</i>&lt;.01]).<sup>4</sup>Even to concede Dr Pickering's "of or by" dilemma, a simple
INDUSTRIAL FATIGUE
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AN ADDRESS
Authors: W. W. DODGE
Journal: JAMA (1895)

On an occasion such as this, are we not forcibly reminded of those beautiful words of Longfellow, in his "Psalm of Life:" "Lives of great men all remind us We can make our lives sublime, And,departing, leave behind us Footprints on the sands of time; "Footprints that perhaps another Sailing o'er life's solemn main, A forlorn and shipwrecked brother Seeing shall take heart again." This evening with pleasurable interest we have witnessed the President of the College of Physicians and Surgeons present to the graduates of the class of 1895, their diplomas. One can scarcely appreciate the heart throbbings of a graduate who receives this "letter of recommendation," this "honor," this "distinction" from the faculty of the college that has been the scene of his hours, days and years of study and now like a fond parent witnesses the coronation of his successful labor. The graduate who worthily receives a
Infringement on Conjugal Rights
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Human Ehrlichiosis—Maryland, 1994
Journal: JAMA (1996)

Ehrlichiosis is an emerging tickborne infectious disease caused by obligate intracellular, gram-negative rickettsia that infect leukocytes. Human monocytic ehrlichiosis (HME) is caused by Ehrlichia chaffeensis and is believed to be transmitted by Amblyomma americanum (the Lone Star tick). Most HME cases have been reported in southeastern and south-central states. During May-July 1994, five cases of serologically confirmed HME were identified among residents of Maryland. All five persons lived near the Chesapeake Bay and had antecedent histories of tick exposure. This report summarizes the clinical and epidemiologic features of these cases and the results of serologic testing at CDC of specimens from Maryland residents with suspected tickborne infection.
NERVE-STRETCHING IN TREATMENT OF CONGENITAL MYOTONIA.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal