Uncomplicated Acute Bronchitis
Authors: Ralph Gonzales, Merle A. Sande
Journal: Annals of Internal Medicine (2001)

Letters6 November 2001Uncomplicated Acute BronchitisRalph Gonzales, MD, MSPH and Merle A. Sande, MDRalph Gonzales, MD, MSPHUniversity of California, San Francisco; San Francisco, CA 94118 (Gonzales)University of Utah; Salt Lake City, UT 84132 (Sande)Search for more papers by this author and Merle A. Sande, MDUniversity of California, San Francisco; San Francisco, CA 94118 (Gonzales)University of Utah; Salt Lake City, UT 84132 (Sande)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-135-9-200111060-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Most studies that support the statement “Immunity after natural infection with pertussis appears to be lifelong” were performed before introduction of the pertussis vaccine, that is, when diagnosis of pertussis was primarily based on clinical criteria. Thus, repeated pertussis infection or exposure in adults with previous incident pertussis infections would not be expected to result in a clinical syndrome resembling whooping cough; this leads to the impression that “immunity after pertussis appears to be lifelong.” Although pertussis infection in adults previously infected with pertussis is possible, estimating the magnitude and clinical implications of this phenomenon is difficult.Studies ...References1. Cherry JD. Epidemiological, clinical, and laboratory aspects of pertussis in adults. Clin Infect Dis. 1999;28 Suppl 2 S112-7. [PMID: 10447028] CrossrefMedlineGoogle Scholar2. Deville JG, Cherry JD, Christenson PD, Pineda E, Leach CT, Kuhls TL, et al . Frequency of unrecognized Bordetella pertussis infections in adults. Clin Infect Dis. 1995;21:639-42. [PMID: 8527557] CrossrefMedlineGoogle Scholar3. Ramirez-Ronda CH, Fuxench-López Z, Nevárez M. Increased pharyngeal bacterial colonization during viral illness. Arch Intern Med. 1981;141:1599-603. [PMID: 7305570] CrossrefMedlineGoogle Scholar4. Heininger U, Schmidt-Schläpfer G, Cherry JD, Stehr K. Clinical validation of a polymerase chain reaction assay for the diagnosis of pertussis by comparison with serology, culture, and symptoms during a large pertussis vaccine efficacy trial. Pediatrics. 2000;105:E31. [PMID: 10699133] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Ralph Gonzales, MD, MSPH; Merle A. Sande, MDAffiliations: University of California, San Francisco; San Francisco, CA 94118 (Gonzales)University of Utah; Salt Lake City, UT 84132 (Sande) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoUncomplicated Acute Bronchitis Ralph Gonzales and Merle A. Sande Uncomplicated Acute Bronchitis Ulrich Heininger Metrics 6 November 2001Volume 135, Issue 9Page: 839-840KeywordsAdultsImmunityPertussisPneumoniaPolymerase chain reactionPopulation statisticsRespiratory pathogensSpecificityStreptococcusUpper respiratory tract infections ePublished: 6 November 2001 Issue Published: 6 November 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...