tbuckley/cabot-search huggingface dataset:
Administrative Medicine
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Rocky Mountain Medical Journal, Denver
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Allergy
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Civil War
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Subnormal levels of glucose in urine. A sign of urinary tract infection
Authors: B. Schersten
Journal: JAMA (1967)

Since the middle of the 19th century, it has been known that normal urine contains small quantities of glucose.<sup>1-3</sup>Nevertheless, the present knowledge concerning the physiological range of urinary glucose concentrations is on the basis of only a few reports. Nagasaki<sup>4</sup>found the normal range to be 2 to 33 mg of glucose per 100 milliliters of urine in a study of 174 randomly selected cases. In specimens of morning urine Haller<sup>5</sup>recorded values from less than 3.1 to 12.5 mg/100 ml of urine in a small series. Using a glucose oxidase method, Fine<sup>6</sup>found the normal range in 740 individuals to be 1 to 15 mg/100 ml of urine. In his studies the urinary specimens were not collected in the fasting state. Renschler<sup>7</sup>used the hexokinase glucose-6-phosphate dehydrogenase method in an extensive study of urinary glucose in 159 individuals. He found the upper limit
Phase I study of ursodeoxycholic acid in combination with 5-fluorouracil, leucovorin, oxaliplatin, and bevacizumab for metastatic colorectal cancer.
Authors: Lily L. Lai, Ken Chiu, Dean Lim, Joseph Chao, Paul Henry Frankel
Journal: Journal of Clinical Oncology (2013)

569 Background: Emerging data links cancer growth with aberrant metabolism. These findings suggest that treatment directed against CRC metabolism may improve survival outcomes. Bile acids are involved in the metabolism of cholesterol and glucose. The bile acid, ursodeoxycholic acid (UDCA), protects against intestinal polyp development in animal and human studies. UDCA effects may be mediated through the nuclear receptor, farnesoid X receptor (FXR), since bile acids are the receptor’s endogenous ligands. FXR is a tumor suppressor in mouse models and a prognostic biomarker in patients with CRC. Bile acid activation of FXR in mouse models suppresses intestinal tumorigenesis. We sought to determine dose and safety of UDCA when added to standard therapy for mCRC. Methods: Patients with mCRC were accrued to an institutionally approved Phase I study. At the end of a 7-day run-in period of oral UDCA, standard doses of 5-fluorouracil, leucovorin, oxaliplatin, and bevacizumab were added. UDCA doses were escalated using a 3+3 design to determine MTD. The use of a run-in period allowed for correlative studies to identify serum biomarkers of FXR activation. Results: 11 patients were treated on three dose levels (250, 500, and 750 mg/day in divided doses). Patients were treated on protocol for a median time of 6 months with a median follow-up of 15 months. Patients were taken off protocol for progression of disease (n = 7); for declining performance status (n = 1); for toxicity (n=1); for patient refusal (n= 1). One patient remains on protocol at this time. No Grade 4 or higher toxicity was identified. Grade 3 toxicities were recorded in 5 patients; the majority was hematologic. Oral glucose tolerance tests, serum glucose and insulin levels, and serum FGF-19 were determined before and after UDCA treatment. Conclusions: UDCA, given with standard chemotherapy and biologic treatment, is safe and well tolerated in patients with mCRC. Further studies are needed to determine the efficacy of targeting FXR and cancer metabolism in mCRC. Supported by a grant from The Phase One Foundation. Clinical trial information: NCT00873275.
Association between a calcineurin B gene variant and idiopathic dilated cardiomyopathy in black South Africans Richard Brooksbank, A J. Woodiwiss, D Skudicky, K Sliwa, GP Candy, D Defterios, P Sareli, GR Norton. University of the Witwatersrand, Johannesburg, South Africa, Chris-Hani Baragwanath Hospital, Johannesburg, South Africa
Journal: Journal of the American College of Cardiology (2001)
Highlights from this issue
Authors: James L. Boyer
Journal: Hepatology (2000)

Chronic Autoimmune Hepatitis Recurs Frequently After Liver Transplantation Raising Questions of ManagementGrowing evidence suggests that patients with chronic autoimmune hepatitis (AIH) have a high incidence of disease recurrence after liver transplantation (LTX).In this study, Reich et al. review the clinical characteristics of a group of 32 patients with AIH both pre-and post-LTX to better assess the significance of this problem.Transplantation was performed in 75% for complications of chronic liver disease that averaged 8 Ϯ 6 years in duration and in 25% for a fulminant or subfulminant course lasting 4 Ϯ 2 months.Although survival over a 3-year follow-up did not differ from patients with non-AIH liver diseases, 25% died (range, 2 days to 52 months) and postoperative complications developed in 71%.Most importantly 75% had one or more episodes of rejection, 22% of whom were steroid resistant and 25% developed biopsy-documented recurrent AIH 12 to 18 months after LTX.In this series, recurrent AIH occurred only in patients transplanted for complications of chronic rather than fulminant disease.Half of the recurrent AIH cases required retransplantation and 2 developed rerecurrent disease.Recurrent disease was not correlated with reductions in immunosuppression.This important study suggests that criteria for transplantation and postoperative management in patients with chronic AIH should be reexamined given the high incidence of posttransplantation recurrence.(Page 693.)
Editors, Contents, Cover details
Authors: Rebecca Schwarzlose, Suzanne Brink, Paige Shaklee, Rolf Van Der Sanden, Ria Otten, Patrick Scheffmann, R Adolphs, R Baillargeon, N Chater, P Dayan, S Dehaene, D Dennett, Y Dudai, A Engel, M Farah, A Friederici, O Hikosaka, R Jackendoff, P Johnson-Laird, N Kanwisher, M Kutas, N Logothetis, J Mcclelland, E Miller, R Poldrack, M Raichle, T Robbins, A Wagner, V Walsh
Journal: Trends in Cognitive Sciences (2016)
The American Year-Book of Medicine And Surgery for 1905. A Yearly Digest of Scientific Progress and Authoritative Opinion in All Branches of Medicine and Surgery. Drawn from Journals, Monographs and Text-Books of the Leading American and Foreign Authors and Investigators. Arranged, with Critical Editorial Comments
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Use of Historical Controls for Animal Experiments
Authors: Takashi Yanagawa, David G. Hoel
Journal: Environmental Health Perspectives (1985)

Statistical methods for the use of historical control data in testing for a trend in proportions in carcinogenicity rodent bioassays are reviewed. Asymptotic properties of the Hoel-Yanagawa exact conditional tests are developed and compared with the Tarone test. It is indicated that the Hoel-Yanagawa test is more powerful than the Tarone test. These tests depend on the beta-binomial parameters which are estimated from historical data. The goodness of fit of beta-binomial distributions to historical data is illustrated by application to the historical control database in the National Toxicology Program. Finally, sensitivities of the exact conditional test to the historical information is discussed and a conservative use of the test is considered.
Immunoaffinity Purification of Dietary Heterocyclic Amine Carcinogens
Authors: Martin Vanderlaan, Mona Hwang, Tanya Djanegara
Journal: Environmental Health Perspectives (1993)

Cooking meats produces a family of heterocylic aromatic amines that are carcinogens in rodents and genotoxic in many short-term assays. Concern that these compounds may be human carcinogens has prompted us to develop immunochemical methods for quantifying these compounds in the human diet and for identifying the parent compounds and metabolites in urine and feces. Previously reported monoclonal antibodies to 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) and 6-phenyl-2-amino-1-methylimidazo[4,5-f]pyridine (PhIP) were used to purify by immunoaffinity these known mutagens and cross-reacting structural analogs from well-done cooked beef and urine samples. Materials recovered from the immunoaffinity columns were subsequently separated by HPLC to purify the known mutagens from cross-reacting chemicals that co-purify by immunoaffinity. Immunoaffinity chromatography was found to be a rapid means of quantifying individual known mutagens, with a minimum of precolumn sample clean-up required. In addition, this procedure has yielded several new mutagens present in cooked meats that are apparently structural analogs of PhIP. Immunoaffinity techniques were also used to purify metabolites from the urine of rats and humans exposed to MeIQx or PhIP. For MeIQx-exposed rats, the combination antibodies immunoconcentrated 75% of the total urinary radioactivity. Analysis of PhIP metabolites recovered from antibody columns is facilitated by the intrinsic fluorescence of PhIP and its metabolites, providing sufficient sensitivity to monitor individuals for the levels of PhIP excreted following consumption of typical western diets.
BOOK REVIEWS
Authors: R. A. ABRAMS
Journal: JNCI Journal of the National Cancer Institute (1992)

BOOK REVIEWS Get access ROSS A. ABRAMS, M.D. ROSS A. ABRAMS, M.D. Radiation Oncology, The Johns Hopkins Hospital, Oncology Center600 N. Wolfe St. Baltimore, MD 21205 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 84, Issue 16, 19 August 1992, Page 1283, https://doi.org/10.1093/jnci/84.16.1283-a Published: 19 August 1992
Reply:
Authors: Warren N. Schmidt, Kyle E. Brown, Bruce A. Luxon, Zhaowen Zhu
Journal: Hepatology (2009)

We are pleased with the interest in our article1 and appreciate the insightful comments made by Dr. Kapoor. He eloquently discussed a variety of anti-inflammatory and other beneficial effects of heme oxygenase-1 (HO-1) that have been described in other disease states. Surprisingly, despite the intense interest in HO-1 in other conditions such as vascular disease,2 investigation of the effects of this classical, yet fascinating, enzyme has been limited in the human liver. We are excited by the possibilities of using HO-1 and heme oxidation products for drug design and additional therapeutic strategies for patients with chronic hepatitis C virus infection. Consequently, the major point of our article was that HO-1 induction or overexpression leads to both inhibition of viral replication as well as reduced oxidative hepatic injury. We feel the stage is now set to test the effectiveness of drugs that induce HO-1 as their mechanism of action for virucidal and anti-inflammatory activities in vivo. Warren N. Schmidt M.D., Ph.D.*, Kyle E. Brown M.D.*, Bruce A. Luxon M.D., Ph.D.*, Zhaowen Zhu M.D., Ph.D.*, * Department of Internal Medicine and Research Service, Veterans Administration Medical Center, and Roy G. and Lucille A. Carver, College of Medicine, University of Iowa, Iowa City, IA.
ABSTRACTS
Journal: Circulation (1956)

Three groups of hypertensive patients were treatedl with parenteral reserpine on a short-term basis.The first group consisted of 14 )atients with severe progressive hypertensive cardiovascular dis- ease.In this group there were 10 patients with ma- lignant hypertension and four patients with severe benign hypertensive cardiovascular disease.All the of reserl)ine in the management of acutely disturbed
The impact on mortality of a national hepatitis C elimination program, Georgia, 2015–2019
Authors: Lia Gvinjilia, Shaun Shadaker, Amiran Gamkrelidze, Tengiz Tsertsvadze, Nikoloz Chkhartishvili, Maia Butsashvili, David Metreveli, Maia Kereselidze, Vladimer Getia, Alexander Turdziladze, Irina Tskhomelidze, Tinatin Kuchuloria, Philip Spradling, Jian Xing, Muazzam Nasrullah, Francisco Averhoff
Journal: Journal of Hepatology (2020)
Developmental Synergism of Steroidal Estrogens in Sex Determination
Authors: Judith M. Bergeron, Emily Willingham, C. Todd Osborn, Turk Rhen, David Crews
Journal: Environmental Health Perspectives (1999)

Gonadal sex in the red-eared slider turtle, Trachemys scripta, is determined by incubation temperature during embryonic development. Evidence suggests that temperature determines sex by influencing steroid hormone metabolism and/or sensitivity: steroidogenic enzyme inhibitors or exogenous sex steroid hormones and their man-made analogs override (or enhance) temperature effects on sex determination. Specifically, nonaromatizable androgens and aromatase inhibitors induce testis differentiation at female-producing temperatures, whereas aromatizable androgens and estrogens induce ovary differentiation at male-producing temperatures. Moreover, natural estrogens and temperature synergize to produce more females than would be expected if estrogens and temperature had purely additive effects on sex determination. In this study, we use sex reversal of turtle embryos incubated at a male-producing temperature to examine synergism among steroidal estrogens: estrone, 17ss-estradiol, and estriol. A low dose of 17ss-estradiol (200 ng) showed significant synergism when administered with a single low dose of estriol (10 ng). Likewise, a single low dose of estrone (250 ng) had a synergistic effect when combined with the same low dose of estriol (10 ng). We conclude that the weak natural estrogens estrone and 17ss-estradiol synergize with a low dose of the more potent estriol to reverse gonadal sex during the critical period of sexual differentiation. These results suggest that weak environmental estrogens may also synergize with stronger natural estrogens.
Psychotherapy of the mentally retarded. Values and cautions
Authors: G. M. Lott
Journal: JAMA (1966)

Some types of the mentally retarded need psychotherapy included in an effective treatment program, and such therapy may be prescribed by their physicians. Accumulated knowledge reveals that the retarded comprise a conglomerate of etiologies and conditions, which require individualized comprehensive remedial plans. These youngsters have the same emotional conflicts, frustration, and guilt feelings as do normals, usually with less ability to correlate experiences and resist flattening feelings of failure. They need opportunities for relative successes. Some case illustrations are included, with special reference to psychotherapeutic processes. In those children with primary or secondary emotional problems, psychotherapy, supportive or deep, is not a holistic remedy. However, it may represent the difference between some degree of community adjustment and protected institutional living or hospital refuge. Long experience indicates the need for coordinated work with the parents.
Successful treatment of acute fascioliasis with bithionol
Authors: Y Bacq
Journal: Hepatology (1991)

Fascioliasis is the parasitic infestation of the liver and biliary tract related to Fasciola hepatica. Bithionol is proposed as the treatment of choice for human fascioliasis without major side effects. However, the efficacy of bithionol has been evaluated in chronic but not in acute fascioliasis. In this study we report on the success of treatment with bithionol in 10 patients with fascioliasis, 8 having acute fascioliasis. The criteria for the diagnosis of fascioliasis were hypereosinophilia, positive immunoelectrophoresis and indirect hemagglutination. Bithionol was given orally to hospitalized patients at the daily dose of 25 mg/kg body wt for 10 days. Three patients with acute fascioliasis received a second course of bithionol 2 or 3 mo after the first because of the recurrence of diarrhea and fatigue in one patient and persistent hypereosinophilia in two patients. All patients were cured. The follow-up period after the first course of treatment was between 16 and 47 mo. No major side effects were observed. We conclude that bithionol is the drug of choice for both acute and chronic fascioliasis. Moreover, its oral administration may allow treatment of fascioliasis in outpatients who do not have serious symptoms. (HEPATOLOGY 1991;14:1066–1069.)
INFLUENZA.
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal