tbuckley/cabot-search huggingface dataset:
7. Diabetes Technology: <i>Standards of Medical Care in Diabetes—2021</i>
Journal: Diabetes Care (2020)

The American Diabetes Association (ADA) “Standards of Medical Care in Diabetes” includes the ADA's current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA Professional Practice Committee, a multidisciplinary expert committee (https://doi.org/10.2337/dc21-SPPC), are responsible for updating the Standards of Care annually, or more frequently as warranted. For a detailed description of ADA standards, statements, and reports, as well as the evidence-grading system for ADA's clinical practice recommendations, please refer to the Standards of Care Introduction (https://doi.org/10.2337/dc21-SINT). Readers who wish to comment on the Standards of Care are invited to do so at professional.diabetes.org/SOC.
Department of Error
Authors: Omar Kujan, Anne-Marie Glenny, Philip Sloan
Journal: The Lancet (2005)

Our study was designed in 1994 when no CONSORT guidelines existed for cluster randomised trials.Thus we had no opportunity to refer to CONSORT at that time; however, the study fulfilled almost all requirements.The randomisation scheme depends to a large extent on local circumstances.Randomisation was done by a statistician independent of our study and the allocation was done randomly using restricted block randomisation, ensuring almost equal distribution of clusters into the study groups.The number of clusters must again reflect the local circumstances.A small number of clusters was used in our study to minimise contamination in view of the high population density in Kerala; a greater number of smaller clusters would have resulted in closer geographic proximity.Two previous interim analyses ignored the cluster design so the differences in risk factor prevalence were significant. 1,2The final analysis took into account the cluster design, and the study groups were well balanced for age, sex, religion, socioeconomic status, pan-tobacco chewing, and alcohol use, but the proportion of trials using more rigorous methods and perhaps aided by sophisticated adjunctive techniques.
Klinische Symptomatologie und Differential-Diagnose innerer Krankheiten.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MYC-containing amplicons in acute myeloid leukemia: Genomic structures, evolution, and transcriptional consequences
Authors: A ĹAbbate, D Tolomeo, I Cifola, M Severgnini, A Turchiano, B Augello, G Squeo, P D´Addabbo, D Traversa, G Daniele, A Lonoce, M Pafundi, M Carella, O Palumbo, A Dolnik, D Muehlematter, J Schoumans, N Van Roy, G De Bellis, G Martinelli, G Merla, L Bullinger, C Haferlach, C T Storlazzi
Journal: Leukemia (2017)

Double minutes (dmin), homogeneously staining regions, and ring chromosomes are vehicles of gene amplification in cancer. The underlying mechanism leading to their formation as well as their structure and function in acute myeloid leukemia (AML) remain mysterious. We combined a range of high-resolution genomic methods to investigate the architecture and expression pattern of amplicons involving chromosome band 8q24 in 23 cases of AML (AML-amp). This revealed that different MYC-dmin architectures can coexist within the same leukemic cell population, indicating a step-wise evolution rather than a single event origin, such as through chromothripsis. This was supported also by the analysis of the chromothripsis criteria, that poorly matched the model in our samples. Furthermore, we found that dmin could evolve toward ring chromosomes stabilized by neocentromeres. Surprisingly, amplified genes (mainly PVT1) frequently participated in fusion transcripts lacking a corresponding DNA template. We also detected a significant overexpression of the circular RNA of PVT1 (circPVT1) in AML-amp cases versus AML with a normal karyotype. Our results show that 8q24 amplicons in AML are surprisingly plastic DNA structures with an unexpected association to novel fusion transcripts and circular RNAs.
The polymeric immunoglobulin receptor is the major calmodulin-binding protein in an endosome fraction from rat liver enriched in recycling receptors
Authors: C Enrich
Journal: Hepatology (1996)

Rat liver endosomes contain one major high-affinity calmodulin-binding protein (CaMBP) that now has been identified as the polymeric immunoglobulin receptor (pIgR). In isolated endosomes pIgR was enriched in the receptor-recycling compartment (RRC); lesser enrichment was found in 'early' endosome (CURL) and much less in 'late' endosome fractions (multivesicular bodies, MVB). The distribution of the major CaMBP, shown by Western blotting or by overlay with I125-calmodulin in the isolated fractions, was consistent with rapid accumulation of I125-immunoglobulin A (IgA) in RRC and CURL after intravenous injection into rats. The receptor was also found in sinusoidal plasma membranes but not in cell fractions containing apical (bile canalicular) or lateral plasma membrane domains of the hepatocyte. The interaction of pIgR with calmodulin was shown by direct binding assays and by affinity chromatography. Thus, calmodulin is the first cytoplasmic protein shown to interact with the pIgR. We postulate that calmodulin regulates pIgA trafficking in rat liver. In addition, the receptor recycling fraction emerges as an endosomal subcompartment involved in pIgA transport via pIgR.
DEPENDABILITY OF DOSAGE IN TABLETS
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Acute Hepatotoxicity of Ethylene and Halogenated Ethylenes after PCB Pretreatment
Authors: Rory B. Conolly, Rudolph J. Jaeger
Journal: Environmental Health Perspectives (1977)

Previous studies from our laboratory have shown that ethylene, vinyl fluoride monomer (VFM), vinyl chloride monomer (VCM), and vinyl bromide monomer (VBM) are all acutely hepatotoxic in rats pretreated with polychlorinated biphenyl (PCB). The time course of hepatic injury development after exposure and several parameters, environmental and chemical, affecting this toxicity were evaluated in the work reported here. Liver injury, as measured by serum alanine-α-ketoglutarate transaminase (SAKT) or sorbitol dehydrogenase (SDH), develops progressively over a 24-hr period following a 4-hr inhalation exposure of PCB-pretreated rats to ethylene or VCM. Environmental temperature during exposure to VCM does not affect hepatotoxicity or mortality below 30.3°C. At 33.8°C, however, mortality and SAKT are dramatically increased. Overnight fasting, which depletes hepatic glutathione (GSH) of PCB-pretreated rats before exposure to ethylene or VCM, significantly increases the hepatotoxicity of these compounds as measured by SDH. The combined effects of fasting and of trichloropropane epoxide (TCPE), an inhibitor of epoxide hydrase (EH), were also examined. TCPE treatment of fasted PCB-pretreated rats immediately before exposure was synergistic in increasing the acute toxicity of ethylene and VCM. TCPE increased mortality in fed or fasted rats exposed to VFM, but there was no effect of fasting alone. Both fasting and TCPE increased the sensitivity of PCB-pretreated rats to VBM, but there was not a clearly synergistic effect of fasting plus TCPE. These data suggest that the acute toxicity of these compounds is mediated through epoxide intermediates.
An Aid to Materia Medica.
Authors: None C. E. W.
Journal: JAMA (1884)

our local medical society in which the author an¬ nounced that the disease was the result of filth and heat.When he had concluded, a member asked, if that were true, how was it possible that any of the children in a certain locality escaped, inasmuch as said neighborhood was remarkable for its filth, and yet during the summer just passed, cholera infantum, in fact all forms of disease had failed to occur, and the whole region was as remarkable for its health.Speaking of medical societies brings up the fact that cur County Medica!Society now numbers its members up to about 500.This is the union of all * for duty as Post Surgeon.
Proteomic identification of serum factors that correlate with reduction of HVPG following curative treatment for hepatitis C virus infection
Authors: Shola Richards, Florian Nigsch, Anna Baiges, Nancy Finkel, Alok Pachori, Sabela Lens, Dale Mongeon, Yiming Zhang, Fanny Turon, José Ferrusquia, Michel Blé Caso, Marta Magaz, Xavier Forns, Chinweike Ukomadu, Virginia Hernandez-Gea, Juan Carlos Garcia Pagan
Journal: Journal of Hepatology (2020)
Reply
Authors: David Healy
Journal: Psychotherapy and Psychosomatics (2004)

Letters| June 08 2004 Reply Subject Area: Psychiatry and Psychology David Healy David Healy North Wales Department of Psychological Medicine, Hergest Unit, Ysbyty Gwynedd, Bangor Gwynedd, UK Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (2004) 73 (4): 260–261. https://doi.org/10.1159/000077747 Article history Published Online: June 08 2004 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation David Healy; Reply. Psychother Psychosom 1 August 2004; 73 (4): 260–261. https://doi.org/10.1159/000077747 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 2004Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Abstract 2659: IRE1á-dependent increase of Gá12, a gep oncogene, augments ER stress-induced catastrophic cell death
Authors: Jihoon Tak, Tae Hyun Kim, Sang Geon Kim
Journal: Cancer Research (2019)

Abstract Hepatocellular carcinoma (HCC) belongs to the most deadly types of cancer since it has a poor prognosis due to its aggressive metastatic phenotype. Endoplasmic reticulum (ER) stress is closely associated with the incidences of a variety of liver diseases including liver injury, regeneration, fibrosis, cirrhosis and often HCC. G protein-coupled receptor (GPCR) signals lead to activation of their downstream pathways through G proteins. Previously, we reported that Gα12 overexpression enhances HCC malignancy, promoting cancer migration and microvascular invasion. However, the role of Gα12 in ER stress-associated pathophysiology in the liver was unclear. Given the link between ER stress and HCC malignancy, this study investigated the effect of ER stress on Gα12, the role of Gα12 in ER stress-mediated hepatocyte death, and the underlying pathway. In the analyses of RNA-sequencing data from mouse liver or primary mouse embryonic fibroblasts challenged with ER stress, Gα12 and C/EBP homologous protein (CHOP) levels correlated with each other. Increases in Gα12 level by unfolded protein response (UPR) under ER stress condition was verified using primary hepatocytes or hepatocyte-derived cell line, confirmative of the close association between Gα12 and UPR. Of note, enforced Gα12 expression under ER stress condition augmented IRE1α level in a RhoA/Rock-dependent pathway. Among the canonical pathways, IRE1α gene silencing distinctly inhibited Gα12 induction elicited by ER stress in hepatocytes. Consistently, overexpression of IRE1α enhanced Gα12 level upon tunicamycin treatment. Similar outcomes were obtained in cells or mice treated with acetaminophen, a representative liver toxicant inducing ER stress response. Overall, our results provide evidence that IRE1α-dependent increase of Gα12 potentiates ER stress response in the liver as mediated by the RhoA-ROCK pathway, enhancing catastrophic death of hepatocytes. Citation Format: Jihoon Tak, Tae Hyun Kim, Sang Geon Kim. IRE1á-dependent increase of Gá12, a gep oncogene, augments ER stress-induced catastrophic cell death [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2659.
Broad-spectrum antibodies against self-antigens and cytokines in RAG deficiency
Authors: Jolan E. Walter, Lindsey B. Rosen, Krisztian Csomos, Jacob M. Rosenberg, Divij Mathew, Marton Keszei, Boglarka Ujhazi, Karin Chen, Yu Nee Lee, Irit Tirosh, Kerry Dobbs, Waleed Al-Herz, Morton J. Cowan, Jennifer Puck, Jack J. Bleesing, Michael S. Grimley, Harry Malech, Suk See De Ravin, Andrew R. Gennery, Roshini S. Abraham, Avni Y. Joshi, Thomas G. Boyce, Manish J. Butte, Kari C. Nadeau, Imelda Balboni, Kathleen E. Sullivan, Javeed Akhter, Mehdi Adeli, Reem A. El-Feky, Dalia H. El-Ghoneimy, Ghassan Dbaibo, Rima Wakim, Chiara Azzari, Paolo Palma, Caterina Cancrini, Kelly Capuder, Antonio Condino-Neto, Beatriz T. Costa-Carvalho, Joao Bosco Oliveira, Chaim Roifman, David Buchbinder, Attila Kumanovics, Jose Luis Franco, Tim Niehues, Catharina Schuetz, Taco Kuijpers, Christina Yee, Janet Chou, Michel J. Masaad, Raif Geha, Gulbu Uzel, Rebecca Gelman, Steven M. Holland, Mike Recher, Paul J. Utz, Sarah K. Browne, Luigi D. Notarangelo
Journal: Journal of Clinical Investigation (2016)

11 and OS-12 were listed twice.The second instances should have been labeled as CID-11 and CID-12, respectively.The correct figure panel is below.
Re: Rapid Method for Tzanck Preparations
Authors: Ronald J. Barr
Journal: JAMA (1977)

<h3>To the Editor.—</h3> In answer to some recent questions and for those interested in our staining method (237: 1119, 1977), I would like to add that prior fixation is not always necessary. If the specimen is prepared as previously outlined, it may be stained immediately (prior to drying) with the Paragon Multiple Stain; the results from this method are quite adequate, since the stain itself serves as a fixative. This is, in fact, how frozen sections are stained. It must be emphasized that this necessitates a staining facility almost at bedside. Therefore, although we do stain fresh material, we have found it technically easier to fix the tissue first.
Positive Lyme serology in subacute bacterial endocarditis. A study of four patients
Authors: A. T. Kaell
Journal: JAMA (1990)

Lyme borreliosis is a multisystem inflammatory disorder caused by the tick-borne spirochete<i>Borrelia burgdorferi</i>. Clinical manifestations are protean, involving the skin, joints, peripheral and central nervous systems, and the heart. However, the presentation of Lyme disease often overlaps with that of other conditions. We describe four patients from a region endemic for Lyme disease who had elevated levels of antibodies reactive to<i>B burgdorferi</i>and whose signs and symptoms were initially attributed to Lyme borreliosis but whose subsequent blood cultures established a diagnosis of nonspirochetal subacute bacterial endocarditis. Although immunoblots on serum samples from three of the four patients were consistent with prior infection from<i>B burgdorferi</i>, a positive immunoblot does not establish active infection. Similarly, seropositivity to<i>B burgdorferi</i>only indicates possible exposure to this organism. The occurrence of positive serologies to<i>B burgdorferi</i>in the presence of other diseases can lead to diagnostic confusion. (<i>JAMA</i>. 1990;264:2916-2918)
Observing the Voiding Bladder
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Minor Surgery and Bandaging, Including the Treatment of Fractures and Dislocations, the Ligation of Arteries, Amputations, Excisions and Resections. Intestinal Anastomosis. Operations upon Nerves and Tendons, Tracheotomy, Intubation of the Larynx, etc.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Two research institutes--London and Rome.
Journal: BMJ (1972)

in which the probability of recurrence of a previous condition -for example, in a family where one child has already died in a similar situation-can lead to preventive action.Of course, these clauses will not be invoked by a magi- stmte unless convincing evidence can be offered of a family's inability safely to care for the dhild.Such evidence can only be acquired by patient, sympathetic, and intensive investigation.This investigation can in itself be therapeutic -so can the plan of care based upon it.This is why it is important to seek out, use, and demand an increasing supply of the social workers and psychiatrists, whose co-operation has been so clinically rewarding and productive of so much understanding already.
Rapid Assessment of the Needs and Health Status of Older Adults After Hurricane Charley—Charlotte, DeSoto, and Hardee Counties, Florida, August 27-31, 2004
Journal: JAMA (2004)

On August 13, 2004, Hurricane Charley, a Category 4 storm with sustained winds of 145 mph, made landfall at a Gulf of Mexico barrier island in Florida, resulting in an estimated 31 deaths statewide and extensive property damage in Charlotte, DeSoto, and Hardee counties. The Florida Department of Health (FLDOH) requested that CDC conduct a rapid needs assessment of older adults (i.e., aged >/=60 years) because this vulnerable age group constitutes a substantial proportion of the population in the most severely affected counties (Charlotte County [43% older adult residents of 141,627 total population], DeSoto County [24% of 32,209], and Hardee County [18% of 36,938]). This report summarizes the findings and recommendations from three rapid needs assessments in these Florida counties. Older adult residents experienced disruptions in both quality-of-life status and medical care for preexisting conditions (e.g., cardiovascular disease, diabetes, and physical disabilities). On the basis of these findings, recommendations were provided to FLDOH for immediate use in deploying resources for response to Hurricane Charley and in planning responses to future disasters.