tbuckley/cabot-search huggingface dataset:
Transtemporal Facial Nerve Decompression
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Second Seed
Authors: Hilda Slive
Journal: JAMA (1987)

<i>Second Seed</i>, a novel by Mary Lake Polan, MD, is an uneven mixture of suspense, international intrigue, and science, ie, in vitro fertilization and surrogate motherhood. For seasoning, a bit of steamy sex has been tossed into the pot (at the behest of the publisher?). The protagonist, Beth, is a young surgeon gifted with talent and beauty. In a most unlikely scenario, her life in Connecticut crosses paths with that of another beautiful young woman, Aliza, who, on the recent death of her father, has become the ruler of an oil-rich Middle Eastern country. Because she is female, according to the laws of her country Aliza cannot keep the throne unless she bears a male child within three years. A villainous cousin, next in line for the throne, plots Aliza's murder. Unfortunately for him, the princess does not die from the attack but lies in a coma. Her husband, American
Highlights of the NCCN Oncology Research Program
Authors: Amit Mahipal, Jaclyn Wessling
Journal: Journal of the National Comprehensive Cancer Network (2020)

This is a single-arm, phase II trial to assess the efficacy of trifluridine/tipiracil in combination with irinotecan in advanced, refractory biliary tract cancers using a 2-stage design.In the first stage, 15 patients will be enrolled.If $2 patients are progression-free and alive at 16 weeks, an additional 10 patients will be enrolled.If #5 of 25 evaluable patients remain progression-free at 16 weeks, then the regimen will be considered ineffective.The total sample size of this study is 28 to account for 3 possible nonevaluable subjects.Patients will receive trifluridine/tipiracil at a dose of 25 mg/m 2 on days 1 through 5 and irinotecan, 180 mg/m 2 on day 1 of each 14-day cycle.Patients will receive treatment until disease progression or development of unacceptable toxicities.Patients will undergo restaging scans every 4 cycles, and will be monitored for adverse events from initiation of study drug administration to 28 days after the last dose.Blood samples will be collected for determination of cell-free DNA (cfDNA) and circulating tumor cells (CTCs) at baseline, after 4 cycles, and at disease progression.Tumor biopsy specimens will be collected before treatment initiation to develop patient-derived tumor organoid (PDO).
National Study of Internal Medicine Manpower: VIII. Internal Medicine Residency and Fellowship Training: 1983 Update
Authors: MARY KAY SCHLEITER
Journal: Annals of Internal Medicine (1983)

A national census of internal medicine residency and fellowship training programs was done in 1981 and 1982, a continuation of surveys conducted annually since 1976. The number of residents in training continues to rise in relation to the increasing number of U.S. medical school graduates. U.S. citizens who are graduates of foreign medical schools comprise a rising number of the residents, 11.6% of the first-year trainees in 1982-1983. Foreign-born graduates of foreign medical schools have declined in the last 2 years to 9.9% of all first-year trainees. The number of blacks in residency training remains less than 5% of the trainee population. More than half of the residents entered subspecialty fellowship training after the completion of residency training. This finding predicts a continuing increase in the ratio of subspecialty internists to general internists in the practicing internal medicine population. The implications of these results for public policy are discussed.
Penicillamine and previous treatment with gold.
Authors: Josephine Arendt
Journal: BMJ (1978)

It should perhaps be pointed out that normal melatonin levels during the night (2400) cover a very large range,2 which in my own laboratory currently extends from undetectable ( < 7) to 161 pg/ml with one value of 269 pg/ml at 0200.Great care is therefore needed in describing a night-time plasma melatonin level as "abnormal."Inter-individual daytime levels are admittedly more stable (mean ± SEM at 1200: 13 9+0 5 pg/ml, n=50, men; 14 6±0 9 pg/ml, n = 45, women) and the main interest of the case reported by Dr Barber and his colleagues lies in the very high daytime levels.
Accord on drug testing, sanctions sought before 1992 Olympics in Europe
Authors: V. S. Cowart
Journal: JAMA (1988)

INTERNATIONAL AGREEMENT on drug testing and sanctions must be achieved before there will be any significant impact on the use of performanceenhancing drugs by athletes. This is the message that sports medicine is taking into the next Olympiad as the world looks toward the 1992 Games in France and Spain. The lesson, of course, emerges from the Olympic competition in South Korea. It is not a new lesson; drug use by athletes has been a part of sports competitions for more than three decades. Meanwhile, in response to the disqualification of Canadian sprinter Ben Johnson for drug use, Canada began a judicial inquiry of the Johnson affair on Nov 15. A Canadian federal judge will hear the evidence—a procedure expected to last into January—and these proceedings have legal standing. <h3>Antidrug Charter Approved</h3> The week before Johnson was disqualified, the International Olympic Committee (IOC) approved an international charter aimed at controlling
‘Refusing Treatment—Please see’: An Analysis of Capacity Assessments Carried out by a Liaison Psychiatry Service
Authors: Gopinath Ranjith, Matthew Hotopf
Journal: Journal of the Royal Society of Medicine (2004)

The assessment of capacity to consent to a healthcare decision is an important part of day-to-day work in general hospitals. The role of liaison psychiatric services in assessment of capacity has not been well studied in British practice. We looked at all such referrals (35) to a liaison psychiatric service in a teaching hospital in the course of one year. The commonest referrals were regarding capacity to consent to a therapeutic procedure, followed by post-discharge placement and ability to self-discharge. Organic mental disorders were the most frequent cause of incapacity. 20 (57%) of the referrals were for patients who had refused the intervention in question, and in 12 of these the contentious issue was resolved. Liaison psychiatric services can be useful not only in offering a second opinion or clarifying the influence of psychopathology on decision-making ability but also mediating between the patient and the clinical team.
Probable Alzheimer's disease in an artist
Authors: J. L. Cummings
Journal: JAMA (1987)

Sequential behavioral and neuropsychological assessments of an artist with probable Alzheimer's disease were made over a 2 1/2-year period. His painting skills underwent dramatic deterioration and a concomitant decline in intellectual ability occurred. Psychological measures suggested that his visuoconstructive skills were relatively less vulnerable to disruption by Alzheimer's disease than were other cognitive functions and that the diminished artistic ability involved motivational, mnemonic, and organizational skills until the later stages of the disease. These observations may contribute to understanding the neurological basis of artistic creativity, as well as the more specific effects of Alzheimer's disease on neuropsychological abilities. (<i>JAMA</i>1987;258:2731-2734)
THE PUBLIC SERVICES.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
VACCINATION SHIELD.
Authors: C. P. FRANKLIN
Journal: JAMA (1901)

After repeated and increasing trouble with irritated, inflamed and infected arms due to the existing forms of vaccination shield, the idea of what a vaccination shield should be has, during the course of the last ten thousand vaccinations, been gradually evolved, until the form described below, and shown in the illustration has been reached, and the writer feels that he has produced a shield which will meet all the conditions properly imposed upon such an important accessory to a perfect vaccination. A shield may be a source of comfort, protection and satisfaction, or it may be productive of distress, irritation and even infection if not suitable. The objections urged against the present forms in use have been obviated in that described below. The shield is made of aluminum, 6 centimeters in diameter to the outer edge of its flange, which latter is curved so that it presents no sharp edges
A choice
Authors: F. Charatan
Journal: BMJ (2003)

advisory board, and use partnerships to strengthen informed consent, help characterise the appropriate standard of care for the control group, and seek post-trial access to interventions.Review committees should include individuals who have experience with clinical trials in developing countries and understand the complexity of partnerships in this setting.Partnerships should be continually strengthened-Just as researchers need to strive to improve recruitment and follow up during a clinical trial, they should also continually try to strengthen partnerships through quality improvement.Specific measures might include educational and outreach programmes to community groups, training for members of advisory boards about the scientific and ethical aspects of clinical trials, as well as attention to the dynamics of research team meetings.Research team meetings need to promote partnerships-Meetings designed to build and sustain collaboration often subvert these goals because of cultural misunderstandings.Patterns of deference to authority based on age, experience, status, and sex may frustrate efforts to elicit feedback and discussion.As a result, collaborative meetings may actually contribute to or sustain a sense of disempowerment.Those who chair meetings must develop the skills to conduct project meetings in ways that ensure everyone speaks and is heard.For instance, chairs might need to explicitly invite people from developing countries to give their views, ask junior people to speak before more senior people have stated their position, or ask participants about their views in private as well as in meetings.Finally, chairs need to elicit the range of perspectives in communities-for example, by asking advisory board members what other perspectives are important in their communities.
Major Morbidity and Mortality Within 1 Month of Ambulatory Surgery and Anesthesia
Authors: Mark A. Warner
Journal: JAMA (1993)

<h3>Objective.</h3> —To determine the incidence and time sequence of mortality and major morbidity after ambulatory surgery. <h3>Design.</h3> —Prospective outcome survey of patients at 16 to 72 hours and 30 days after their surgical procedures. <h3>Setting.</h3> —A tertiary care rural referral center providing ambulatory care. <h3>Patients.</h3> —A total of 38598 patients aged 18 years and older undergoing 45090 consecutive ambulatory procedures and anesthetics. Contact rates for 72 hours and 30 days were 99.94% and 95.9%, respectively. <h3>Main Outcome Measures.</h3> —Mortality and major morbidity incidences, including myocardial infarction, central nervous system deficit, pulmonary embolism, and respiratory failure. <h3>Results.</h3> —Thirty-three patients either experienced major morbidity or died (1:1366 [proportional risk]). Four patients died (1:11 273), two of myocardial infarction and two in automobile accidents. No patient died of a medical complication within 1 week of surgery. Of the 31 patients who developed a major morbidity (1:1455), 14 (45%) had myocardial infarction (1:3220), seven (23%) had a central nervous system deficit (1:64441), five (16%) had pulmonary embolism (1:9018), and five (16%) had respiratory failure (1:9018). Four events (13%) occurred within 8 hours of surgery (1:11 273), 15 (48%) in the next 40 hours (1:3006), and 12 (39%) in the next 28 days (1:3758). <h3>Conclusion.</h3> —In this ambulatory surgical population, more than one third of major morbidity occurred 48 hours or later after surgery. Overall morbidity and mortality rates, however, were very low. (<i>JAMA</i>. 1993;270:1437-1441)
Psychiatric syndromes in critically ill patients
Authors: W. F. Kiely
Journal: JAMA (1976)

THE WIDESPREAD development of critical care units in general hospitals during the past decade has produced many benefits for the seriously ill and injured. Among the less heralded of these has been the sharpened focus of attention on altered states of consciousness, emotional reactions, and behavioral patterns of the critically ill.<sup>1</sup>Psysicians and nurses are called on to appraise and evaluate cognitive clarity, feelings, and behavior of patients. The importance of the patient's previous life experiences, coping style, and personality assets and vulnerabilities serve as the basis for planning and implementing treatment programs in such intensive care facilities.<sup>2</sup>Physiologic and psychologic adaptive patterns in the face of stress are part of a unitary response to challenge, and both reflect subcortically centered systems of defense. <h3>Approach vs Avoidance Patterns</h3> Hess,<sup>3</sup>as early as 1925, pointed out that an animal's reaction to environmental challenge is importantly reflective of the
Pituitary Adenomas
Authors: Mark E. Molitch
Journal: Annals of Internal Medicine (1995)

Letters15 March 1995Pituitary AdenomasMark E. MolitchMark E. MolitchSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-122-6-199503150-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Kupersmith and colleagues [1] reported that enlargement of pituitary adenomas with baseline heights of 1.2 cm or more in six patients during pregnancy resulted in visual field defects. Such enlargement is relatively common in women with prolactin-secreting macroadenomas [2]; however, this is the first report (that I am aware of) of enlargement of a growth hormone-secreting tumor in a patient with acromegaly or a “clinically nonfunctioning” tumor. These tumors did not secrete prolactin. These aspects deserve emphasis because they will influence clinicians with respect to prepregnancy counseling and in follow-up during pregnancy.Readers should not think that ...References1. Kupersmith MJ, Rosenberg C, Kleinberg D. Visual loss in pregnant women with pituitary adenomas. Ann Intern Med. 1994; 121:473-7. Google Scholar2. Molitch ME. Pregnancy and the hyperprolactinemic woman. N Engl J Med. 1985; 213:1364-70. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byProlactin in men's health and diseasePituitary TumoursLymphocytic hypophysitis complicated by post-partum haemorrhage 15 March 1995Volume 122, Issue 6Page: 476KeywordsAcromegalyPituitary tumorsPregnancyProlactin Issue Published: 15 March 1995 Copyright & PermissionsCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Corrections
Journal: JNCI Journal of the National Cancer Institute (1978)

In “Deuterium Isotope Effect in the Microsomal Metabolism of Dimethylnitrosamine” by Doron Dagani and Michael C. Archer (57:955–957), a numerical error has been discovered in the data reported on page 956, text-figure 1, which changes three of the kinetic parameters. The correct Km value for DMN-d6 is 110 mm (not 74 mm). The previously reported Km value of 120 mm for DMN remains unchanged. The correct Vmax values for DMN and DMN-d6 are 13.0 and 4.7 nmoles HCHO/mg protein/minute, respectively (not 20 and 5.2 nmoles). KHm/KDm is therefore 1.1 (not 1.6), and VHmax/VDmax is 2.8 (not 3.8). These changes affect neither the conclusions nor the significance of the original paper.
THE KIRKPATRICK CONSUMPTION CURE FAKE
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Lecture on the Functional Cardiac Murmurs of Anaemia
Authors: B. Bramwell
Journal: BMJ (1883)

To the other points previously advanced in support of and against Dr. Balfour's theory, the following must be added.5. That the pulmonary second sound is accentuated.We all, of course, know, that in mitral regurgitation, the pulmonary second sound is accentuated in consequence of the increased blood-pressure in the pulmonary artery, which results from the mitral lesion.If, therefore, this accentuation occurs in the earlier stages of chlorosis, and if it cannot be satisfactorily accounted for in any other manner (than as the result of mitral regurgitation),we must, of course, admit that it is strongly corroborative of Dr. Balfour's theory, always premising that there is no fatal objection to that view.Now, I at once admit that, in the later stages of anmemia, the pulmonary second sound is often intensified, and that the accentuation may be due to the mitral regurgitation which is often present in the advanced stages of that condition.In the earlier stages of chilorosis, too, I have frequently (though not invariably) found the pulmonary second sound louder than the aortic.I have been in the habit of regarding the accentuation, which occurs in the early stages of chlorosis, as apparent rather than real; in other words, I have supposed that the aortic second sound was diminished in in- teasity, while the pulmonary retained its normal loudness.Pos- sibly, I may be mistaken in this view; and I am certainly not pre- pared to say that true accentuation of the pulmonary second sound does not occur, even in the earlier stages of chlorosis.But even granting that the accentuation were always present and well marked, I cannot admit that it is sufficiently strong evidence to counterbalance the grave objections which have been advanced against the mitral regurgitation view.In particular, the objections, which Dr. Russell has so ably, and which I can not only corroborate, but also strengthen-(1) that in the most advanced stages of anemia, as seen after death, the left auricular appendix is not dilated (in one of my cases it was actually smaller than normal); and (2) that when the right heart becomes dilated, as it does in conditions of ansmia, the appendix of the left auricle recedes from, rather than comes in closer contact with, the chest-wall-seem to me to negative Dr. Balfour's view.I feel obliged, therefore, to suppose, that if the pulmonary second sound is actually intensified, the accentuation must be due to some other cause than mitral re-
Leads from the MMWR. Occupational finger injuries--United States
Journal: JAMA (1983)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cutaneous Medicine
Authors: John G. Downing
Journal: New England Journal of Medicine (1947)

Infections Virus Extensive herpetic eruptions of the lips may be serious, owing to subsequent scarring causing circumoral constriction. Herpes labialis occurs in 25 to 50 per cent of cases of cerebrospinal meningitis on the fourth or fifth day of the disease. It is probably due to the ever-present virus, being activated by febrile illness.Toward the close of the nineteenth century a complication of infantile eczema characterized by a so-called "varicelliform eruption" was first described by Kaposi156 as an acute outbreak of numerous vesicles, partly scattered and partly arranged in groups. The vesicles are as large as lentils and are . . .