tbuckley/cabot-search huggingface dataset:
Myasthenia Gravis
Authors: Henry R. Viets
Journal: New England Journal of Medicine (1954)

A REVIEW of myasthenia gravis was published in the Journal 1 in 1951, to bring the survey of the published reports up to the midyear. The present paper continues the survey of the subject to the close of 1953, for the most part covering a period of about two and a half years. Although practically every paper printed during that time has been scrutinized, only part of the literature is included in the references here discussed. Papers of minor interest, single case reports of minimal value and a few reviews have been omitted. It is hoped that no paper of importance . . .
16. Ordering Antimicrobial Agents for Hospitalized Patients
Journal: JAMA (1977)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical Significance of Minimal Residual Disease (MRD), as Assessed by Different Techniques, after Stem Cell Transplantation (SCT) for Chronic Lymphocytic Leukemia (CLL).
Authors: Carol Moreno, Neus Villamor, Jordi Esteve, Dolors Colomer, Francesc Bosch, Elias Campo, Emili Montserrat
Journal: Blood (2005)
Vaccination Coverage of 2-Year-Old Children—United States, 1991-1992
Journal: JAMA (1994)

The primary goal of the Childhood Immunization Initiative (CII) is to increase, by 1996, vaccination levels for 2-year-old children to at least 90% for the most critical doses in the vaccination series (i.e., one dose of measles-mumps-rubella vaccine [MMR] and at least three doses each of diphtheria and tetanus toxoids and pertussis vaccine [DTP], oral poliovirus vaccine, and Haemophilus influenzae type b vaccine [Hib]) and to at least 70% for three or more doses of hepatitis B (Hep B) vaccine (1). This report presents estimates, based on the National Health Interview Survey (NHIS), of the annual national vaccination coverage levels for children aged 19-35 months (median: 27 months) for 1993, compares estimates for 1993 with those for 1992, and compares estimates for the first 6 months of 1993 with third and fourth quarter 1993 estimates.
OC-059 Low Dose Azathioprine And Allopurinol In Azathioprine Intolerant Patients: Is It Tolerated And Is It Effective In Ibd?
Authors: HE Johnson, SA Weaver, SD McLaughlin
Journal: Gut (2014)

<h3>Introduction</h3> Despite the advancement and introduction of new biological therapies, thiopurines remain effective treatment options for the maintenance of remission for both ulcerative colitis (UC) and Crohn’s disease (CD). Once tolerated and therapeutic, thiopurines have many advantages over biologics for long-term maintenance therapy. However, it has been documented that intolerance and adverse events are common. We have previously published our 36 month follow-up data reporting that 56.5% of our patients stop thiopurines due to side effects, abnormal liver function tests (LFTs) or therapeutic failure. Low dose azathioprine and allopurinol (LDAA) co-therapy is a well proven treatment option for patients who develop side effects or hepatotoxicity with standard dose azathioprine. LDAA has been used at our institution since 2010. <h3>Aim</h3> to report the safety, tolerability and therapeutic outcome at 12 months, for LDAA in patients who have failed standard dose azathioprine. <h3>Methods</h3> We maintain a prospective IBD data-base. After starting LDAA we monitor full blood count and LFTs weekly for 8 weeks. 6-Thioguanine (6-TGN) and 6-Methyl-mercaptopurine (6 MMPN) nucleotide levels are checked at 4–6 weeks. We searched our database for patients who started LDAA and had a minimum of 12 months follow-up. We recorded the indications for therapy, metabolite levels, and blood monitoring and clinical outcomes. <h3>Results</h3> 62 patients were started on LDAA. 25 (40%) were male. Mean age was 47 (range 16 – 77). Disease type was UC, 21; CD, 35; IBD(U), 6. Reasons intolerant to standard dose azathioprine were: drug side effects (nausea and arthralgia) 24; hepatitis (ALT 2x upper limit normal) 20; Hypermethylation (TGN: MMPN ratio &gt;11), 12. Gout 4; High TPMT 2. At 12 months 44 (70%) remained on LDAA and were in clinical remission (HBI &lt;1 for CD), (stool frequency &lt;4 and no bleeding for UC) with therapeutic 6TGN levels on LDAA, of these 7 (11%) required additional treatment with biologic therapy. Of the remaining 18 (29%) patients, 3 (5%) were lost to follow up and 1 (2%) chose to stop LDAA. 1 patient (UC) required a colectomy. 3 (5%) stopped LDAA to conceive. 10/62 (16%) remained intolerant and treatment was stopped. One patient developed myelosuppression WCC &lt;3 and stopped therapy. No patients developed abnormal LFTs on LDAA. <h3>Conclusion</h3> LDAA is well tolerated and effective in patients who failed standard dose azathioprine due to drug side effects and hepatotoxicity. This therapy results in resolution of hepatotoxicity and will allow more IBD patients to achieve clinical remission. <h3>Disclosure of Interest</h3> None Declared.
Incorrect Spelling of Coauthor Surname
Authors: Yoichiro Takayanagi, Adam Spira, Ramin Mojtabai
Journal: JAMA Psychiatry (2018)

Willemijn J. Jansen, PhD; Rik Ossenkoppele, PhD; Betty M. Tijms, PhD; Anne M. Fagan, PhD; Oskar Hansson, MD, PhD; William E. Klunk, MD, PhD; Wiesje M. van der Flier, PhD; Victor L. Villemagne, MD, PhD; Giovanni B. Frisoni, MD; Adam S. Fleisher, MD, MAS; Alberto Lleó, MD, PhD; Mark A. Mintun, MD; Anders Wallin, MD, PhD; Sebastiaan Engelborghs, MD, PhD; Duk L. Na, MD, PhD; Gäel Chételat, PhD; José Luis Molinuevo, MD, PhD; Susan M. Landau, PhD; Niklas Mattsson, MD, PhD; Johannes Kornhuber, MD; Osama Sabri, MD, PhD; Christopher C. Rowe, MD, PhD; Lucilla Parnetti, MD, PhD; Julius Popp, MD; Tormod Fladby, MD, PhD; William J. Jagust, MD, PhD; Pauline Aalten, PhD; Dong Young Lee, MD, PhD; Rik Vandenberghe, MD, PhD; Catarina Resende de Oliveira, MD, PhD; Elisabeth Kapaki, MD, PhD; Lutz Froelich, MD, PhD; Adrian Ivanoiu, MD, PhD; Tomasz Gabryelewicz, MD, PhD; Marcel M. Verbeek, PhD; Páscual Sanchez-Juan, MD, PhD; Helmut Hildebrandt, PhD; Vincent Camus, MD, PhD; Marzena Zboch, MD, PhD; David J. Brooks, MD, PhD; Alexander Drzezga, MD, PhD; Juha O. Rinne, MD, PhD; Andrew Newberg, MD, PhD; Alexandre de Mendonça, MD, PhD; Marie Sarazin, MD, PhD; Gil D. Rabinovici, MD; Karine Madsen, MD, PhD; Milica G. Kramberger, MD, PhD; Agneta Nordberg, MD, PhD; Vincent Mok, MD; Barbara Mroczko, MD; David A. Wolk, MD; Philipp T. Meyer, MD, PhD; Magda Tsolaki, MD, PhD; Philip Scheltens, MD, PhD; Frans R. J. Verhey, MD, PhD; Pieter Jelle Visser, MD, PhD; Amyloid Biomarker Study Group; Dag Aarsland, MD, PhD; Daniel Alcolea, MD; Myriam Alexander, PhD; Ina S. Almdahl, MD; Steven E. Arnold, MD; Inês Baldeiras, PhD; Henryk Barthel, MD, PhD; Bart N.M. van Berckel, MD, PhD; Kaj Blennow, MD, PhD; Mark A. van Buchem, MD, PhD; Enrica Cavedo, PhD; Kewei Chen, PhD; Elena Chipi, PhD; Ann D. Cohen, PhD; Stefan Förster, MD, PhD; Juan Fortea, PhD; Kristian S. Frederiksen, MD, PhD; Yvonne Freund-Levi, MD, PhD; Olymbia Gkatzima, MSc; Mark Forrest Gordon, MD; Timo Grimmer, MD, PhD; Harald Hampel, MD, PhD; Lucrezia Hausner, MD, PhD; Sabine Hellwig, MD; Sanna-Kaisa Herukka, PhD; Peter Johannsen, MD, PhD; Aleksandra Klimkowicz-Mrowiec, MD, PhD; Sebastian Köhler, PhD; Norman Koglin, PhD; Koen van Laere, MD, PhD, DrSc; Mony de Leon, MD, PhD; Viviana Lisetti, MSc; Wolfgang Maier, MD, PhD; Jan Marcusson, MD, PhD; Olga Meulenbroek, PhD; Hanne M. Møllergård, PhD; John C. Morris, MD, PhD; Arto Nordlund, PhD; Gerald P. Novak, MD; George P. Paraskevas, MD, PhD; Gayan Perera, PhD; Oliver Peters, MD; Inez H. G. B. Ramakers, PhD; Lorena Rami, MSc; Eloy Rodríguez-Rodríguez, MD, PhD; Catherine M. Roe, PhD; Uros Rot, MD, PhD; Eckart Rüther, MD, PhD; Isabel Santana, MD, PhD; Johannes Schröder, MD, PhD; Sang W. Seo, MD, PhD; Hilkka Soininen, MD, PhD; Luiza Spiru, MD, PhD; Erik Stomrud, MD, PhD; Hanne Struyfs, MSc; Charlotte E. Teunissen, PhD; Stephanie J. B. Vos, PhD; Linda J. C. van Waalwijk van Doorn, MSc; Gunhild Waldemar, MD, DMsc; Åsa K. Wallin, MD, PhD; Jens Wiltfang, MD, PhD; Henrik Zetterberg, MD, PhD
SOME TRUTHS ABOUT ALCOHOL
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Archives of Internal Medicine, Chicago
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Expanding Long-term Care Options for Persons With Serious Mental Illness
Authors: Kenneth J. Dudek
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Juvenile Rheumatism: A Clinical Survey
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Mitochondrion
Authors: D. F. Tapley, D. V. Kimberg, J. L. Buchanan
Journal: New England Journal of Medicine (1967)

Oxidative PhosphorylationAt certain points along the respiratory chain some of the energy produced by oxidation-reduction is used to form the high-energy phosphate bond of ATP. The process that couples the esterification of inorganic phosphate (ADP + Pi = ATP) to electron transport is known as "oxidative phosphorylation."Belitzer and Tzibakova,58 in 1939, and Ochoa,59 two years later, demonstrated a stoichiometry between oxygen consumption (or electron transport) and inorganic phosphate esterification. It was subsequently shown that for each pair of reducing equivalents transferred from an NAD-linked substrate to oxygen, 3 inorganic phosphate anions were esterified, giving a ratio of inorganic . . .
Quality assurance for office laboratories
Journal: JAMA (1986)

<h3>In Reply.—</h3> Dr Pitts raises two important issues in his letter concerning quality assurance for office laboratories. The first concerns the professional responsibility of the office practitioner-laboratory director for the reliability of test results produced by that laboratory and used in patient care. We must point out that the practitioner will be professionally responsible for erroneous results used in patient care if these involve injury to a patient. Consequently, taking laboratory test analysis into the office requires that clinicians develop a new range of understanding so they can respond to plaintiffs' questions concerning whether particular analyses were functioning properly at the time the result was produced and whether the result was produced from a specimen that actually came from the patient. This involves more than the dreary trappings of laboratory quality control but, rather, an understanding of the issues and problems underlying the development of such programs. The second important
Incorrect Spelling
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The National Institute of Environmental Health Sciences: A Perspective
Authors: Elizabeth Y. James, George M. Kingman
Journal: Environmental Health Perspectives (1978)

This paper attempts to place the programs of the National Institute of Environmental Health Sciences into correct perspective in relation to the other Federal environmental programs. Its goal is to illuminate the field of environmental health as a new field in science that confronts a wide variety of complex and diverse issues. It is unrealistic to believe these issues can somehow be rendered less complex and diverse. What is hoped is that the Institute will contribute to providing the tools which will make is possible for us to develop principles leading to an understanding of the underlying problems. Then we should be able to build a base for effective public health programs for the years ahead, years that should prove to be as eventful and challenging as those just past.
In This Issue
Journal: Journal of Clinical Investigation (2010)

New role for mast cells in afibAtrial fibrosis is a hallmark of atrial fibrillation (AF), the most common cardiac arrhythmia.It is thought to perpetuate AF.The mechanisms underlying the development of atrial fibrosis in AF remain unclear, although a role for inflammation has been suggested.Consistent with this, Liao and colleagues have identified a role for immune cells known as mast cells in inducing atrial fibrosis and AF in pressure-overloaded mouse hearts (242-253).Initial analysis indicated that mast cells accumulate and become activated in the atrium of pressure-overloaded mouse hearts, which are characterized by atrial fibrosis and enhanced susceptibility to induction of AF.Stabilizing mast cells with cromolyn and generating mast cell-deficient mice through bone marrow transplantation reduced fibrotic atrial remodeling and susceptibility to AF induction after pressure overload.Mechanistic studies determined that atrium-infiltrating mast cells increased PDGF-A synthesis, which subsequently promoted atrial fibrosis and susceptibility to AF induction in pressure-overloaded mouse hearts.These data led the authors to suggest that targeting the mast cell/PDGF-A axis might provide a way to prevent AF in stressed hearts, although they caution that further studies are needed to determine whether the same mechanism operates upstream of AF in large animals.
From the Centers for Disease Control and Prevention. Invasive group A streptococcal infections--United Kingdom, 1994
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Improved chemotherapy for small-cell undifferentiated lung cancer
Authors: L. H. Einhorn
Journal: JAMA (1976)

Bleomycin sulfate, doxorubicin hydrochloride, cyclophosphamide, and vincristine sulfate combination chemotherapy was given to 29 patients with small-cell undifferentiated lung cancer. Only four of these patients had limited disease, and in these patients there was 100% complete remission; two of these four patients remain in complete remission at more than 52 and 60 weeks. Of the 25 patients with generalized disease, 18 (72%) had neoplasm regression (&gt;50%), including two with complete remission (8%). The median duration of remission was 25 weeks. The median survival time from diagnosis was 39 weeks and that from initiation of therapy, 35 weeks. The drug regimen was well tolerated, and although substantial leukopenia was produced, there were only three patients in whom granulocytopenic infections developed. There was only one drug-related death. (<i>JAMA</i>235:1225-1229, 1976)
Renal Vein Thrombosis
Authors: Robert A. Older
Journal: JAMA (1978)

THE ASSOCIATION between renal vein thrombosis and the nephrotic syndrome is well documented in the literature. Although some investigators have suggested that renal vein thrombosis precedes the onset of the nephrotic syndrome and hence serves as the initiating event,<sup>1</sup>more recent observations imply that the nephrotic syndrome usually precedes the development of renal vein thrombosis. We report such a progression of events in a patient who had the nephrotic syndrome and in whom idiopathic membranous glomerulonephritis was found on histologic examination of the kidney. Later, renal vein thrombosis complicated the course of the patient's illness. <h3>Report of a Case</h3> A 54-year-old man was hospitalized with peripheral edema, mild hypertension, and proteinuria of three months' duration. The blood pressure on admission was 150/80 mm Hg, and there was pitting edema (2+) to the level of the knees bilaterally. Results of the remaining aspects of the physical examination were unremarkable. Evaluation