tbuckley/cabot-search huggingface dataset:
Certain Samaritans.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An Address on the Revival of Ovariotomy, and its Influence on Modern Surgery
Authors: S. Wells
Journal: BMJ (1884)

MEDICAL SocuETY,-Nekt to the satisfaction which attends the ful- filment of the first duty of our calling-the relief of suffering and the prolongation of human life, which the Roman orator said raised the giver of health to man nearer to.theDivine Giver of life I know of no higher privilege thai that of being permitted to .ad4resseducated minds, of endeavouring to influence for good, medical thouight, and opinion, and practice-whether by the aid of'the art of the printerthat" ' magic which embalmis the thought "-or by addressing such an
Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's disease
Authors: Andrew M. Smith, Farooq Z. Rahman, Bu'Hussain Hayee, Simon J. Graham, Daniel J.B. Marks, Gavin W. Sewell, Christine D. Palmer, Jonathan Wilde, Brian M.J. Foxwell, Israel S. Gloger, Trevor Sweeting, Mark Marsh, Ann P. Walker, Stuart L. Bloom, Anthony W. Segal
Journal: The Journal of Experimental Medicine (2009)
Child deaths and infection.
Journal: BMJ (1965)

a variety of drugs was often required, preparations of thiazides with enteric-coated potassium chloride are the one common factor.Indeed all 36 patients in a series reported from Stockholm' were taking these drugs.Animal experi- ments indicate that potassium chloride is the offending substance, possibly because of the speed with which it is released from enteric-coated tablets,4 and that it acts either directly on the mucosa or via the submucosal blood-vessels.
Broder Asks House Appropriations Committee for Nearly $1.5 Billion in 1990
Journal: JNCI Journal of the National Cancer Institute (1989)

Journal Article Broder Asks House Appropriations Committee for Nearly $1.5 Billion in 1990 Get access JNCI: Journal of the National Cancer Institute, Volume 81, Issue 8, 19 April 1989, Pages 564–567, https://doi.org/10.1093/jnci/81.8.564 Published: 03 January 1990
Abstract 1078: β-Adrenergic Stimulation of Ca/Calmodulin-Dependent Protein Kinase II (CaMKII) Overexpressing Myocytes Increases Sarcoplasmic Reticulum (SR) Calcium Leak Causing KN-93 Sensitive Arrhythmias
Authors: Daniel P Wadsack, Michael Kohlhaas, Adam G Rokita, Stefan Neef, Lars S Maier
Journal: Circulation (2007)

CaMKII is associated with hypertrophy, heart failure and alters intracellular Ca homeostasis. An increased SR Ca leak due to phosphorylation of SR Ca release channels by CaMKII leads to decreased SR Ca content and impaired contractility. This loss of Ca from the SR may also contribute to arrhythmias. We investigated whether β-adrenergic stimulation with isoproterenol (ISO) normalizes SR Ca content and whether inhibiting CaMKII reduces arrhythmias. CaMKII-overexpressing rabbit and mouse myocytes were investigated. Cell shortening, Ca fluorescence (fluo-3) and the incidence of arrhythmias were assessed. An arrhythmia-score differentiated between: early-spike-arrhythmias (ESA), late-spike-arrhythmias (LSA) and permanent arrhythmias (PA). ISO (37°C) had significantly different effects on myocytes with acute (24 h, rabbit, n=34) or chronic (22 w, mouse, n=34) CaMKII overexpression vs corresponding control myocytes (LacZ, n=21 or WT n=34). CaMKII overexpression lead to an ISO concentration-dependent (10 −10 -10 −5 mol/L) inotropic but compared to WT (or LacZ, respectively) impaired shortening and Ca transients (two-way ANOVA, P &lt;0.05). A similar difference between CaMKII-overexpressing (n=17) and WT (n=19) myocytes was also seen during a shortening-frequency protocol (stepwise increase from 0.1– 4 Hz, two-way ANOVA, P &lt;0.05). Arrhythmias spontaneously occurred in CaMKII-overexpressing mouse myocytes. With β-inotropic stimulation (10 −6 mol/L ISO) arrhythmias were increased 6.4-fold. Appearance of ESA and PA could be significantly reduced by KN-93 (1 μmol/L). At a basal stimulation rate of 1 Hz and 10 −7 mol/L ISO, PA could be dramatically reduced by half from control-level 21.43% (KN-92, inactive derivative, n=42) down to 10.87% (KN-93, n=46) arrhythmic events. ESA could be reduced almost 4-fold from 16.67% (KN-92) to 4.35% in the presence of KN-93. We conclude from these data that increasing ISO concentrations exerts positive inotropic effects but cannot normalize altered Ca handling in CaMKII-overexpressing myocytes. This may be due to an increased SR Ca leak under these conditions thus contributing to the arrhythmias observed. CaMKII inhibition clearly can reduce arrhythmias in the presence of β-adrenergic stimulation with ISO.
Bromism.
Authors: A F Boyles, D J Martin
Journal: BMJ (1967)

Improving the Psychiatric Services SIR,-Being very interested in and com- mitted to the task of trying to plan and provide suitable hospital services for elderly people, I think that Dr. H. Jacobs's letter (16 December, p. 681) calls for some comment.I refer to the very popular notion of "x weeks in and x weeks out geriatric service."Such service is not necessarily the sort of panacea that many people seek.It is very difficult indeed to keep to any such time- table.One knows that shuttling the elderly from here to there will in itself very often affect them adversely and one had found that at the end of the allocated stay in hospital the patient is much worse than at the time of admission.Although one is keen to help the relatives and benefactors of frail elderly people by giving them respite, and is able to do this in selected cases, I have come after many years to believe that the primary task of the geriatrician is to treat vigorously whichever patients have tractable diseases, tempering such treatment with, one hopes, humanity and common sense.As for day hospitals, I am completely sold on their virtues and efficacy.I am beginning to think that these, paralleled by local authority day centres, might very well reduce dramatically the expense of providing in future for the needs of the elderly.-Iam, etc.,
Trauma Surgery
Authors: Robert J. Baker
Journal: JAMA (1988)

It is now some 22 years since the establishment of the first Level I trauma center at Cook County Hospital in Chicago, and the recognition of traumatology as an organized, important discipline is universal. Trauma remains the major killer of patients who die between the ages of 1 and 40 years, and US data of 1985 continue to show that approximately 100 000 deaths each year are due to trauma, 8 million hospitalizable injuries occur per annum, and the net cost to the economy of this carnage is between $100 and $140 billion annually. The most important public health emphasis in attacking this devastating problem has only recently been brought to bear on the appropriate target, namely, preventing injury rather than focusing solely on the treatment of injury once it has occurred. As deaths from cancer, heart disease, and stroke have diminished in the past two decades, deaths from trauma
First-line PD1/PD-L1 inhibitors for platinum-ineligible advanced urothelial carcinoma (UC).
Authors: Archana Agarwal, Gregory Russell Pond, Alexandra Drakaki, Jae-Lyun Lee, Mehmet Asim Bilen, Giuseppe Di Lorenzo, Petros Grivas, Moshe Chaim Ornstein, Pedro C. Barata, Shilpa Gupta, Syed A. Hussain, Catherine Curran, Jorge A. Garcia, Guru Sonpavde
Journal: Journal of Clinical Oncology (2019)

432 Background: FDA modified the label for the use of 1st-line pembrolizumab or atezolizumab therapy to PD-L1 high cisplatin-ineligible or platinum-ineligible UC patients (pts) regardless of PD-L1 expression. However, the outcomes when using PD1/PD-L1 inhibitors for platinum-ineligible pts are unclear. We conducted a retrospective study to evaluate clinical outcomes with first-line PD1/PD-L1 inhibitors for platinum-ineligible pts with advanced UC in a real-world setting. Methods: We collected data retrospectively from 6 institutions. The following criteria were deemed to render pts platinum-ineligible although physician discretion was also allowed: Cr Cl &lt; 30 ml/min, ECOG-PS 3, Both Cr Cl 30 to &lt; 60 AND ECOG-PS 2. Demographic and clinical variables and outcomes (overall response rate [ORR], overall survival [OS]) were collected. A Cox regression analysis was done to study the association of baseline variables with response and survival. Results: Data were available for 45 pts. Pts received atezolizumab [n = 24], pembrolizumab [n = 11], nivolumab [n = 7] and durvalumab [n = 3]. The mean age was 72.2 (range 45-90) years. The reasons for platinum-ineligibility were: Cr Cl &lt; 30 ml/min (n = 17), ECOG-PS 3 (n = 3), ECOG-PS 2 plus Cr Cl &lt; 60 ml/min (n = 7), elderly with co-morbidities (n = 12), and reason was unavailable for 6 pts. The median OS was 37 weeks (CI 30-80). ORR was 27.3%: Complete response in 3 pts [6.8%], partial response in 9 pts [20.5%], stable disease in 11 pts [25%] and progressive disease in 21 pts [47.7%] and data for 1 patient was unavailable. Toxicity of any grade were seen in 42.2% of pts and Grade ≥3 toxicity in 9 pts’ [20%]. There were no treatment-related deaths. Anemia (HR = 0.75, 95% CI 0.62 - 0.92, P = 0.005) and liver metastasis (HR = 1.17, 95% CI 0.47 - 2.93, P = 0.017) correlated with shorter OS. Conclusions: To our knowledge, this is the 1st report of efficacy and toxicity of PD1/PD-L1 inhibitors as1st-line therapy for platinum ineligible UC. Data appear comparable to those reported previously in unselected cisplatin-ineligible pts receiving pembrolizumab or atezolizumab in phase II trials. Validation is needed in larger datasets and prospective trials.
Pressure Ulcers
Authors: Francesco Landi
Journal: Annals of Internal Medicine (1996)

Letters1 September 1996Pressure UlcersFrancesco Landi, MD, Antonio Sgadari, MD, and Roberto Bernabei, MDFrancesco Landi, MDCatholic University of Sacred Heart, Rome, Italy, Antonio Sgadari, MDCatholic University of Sacred Heart, Rome, Italy, and Roberto Bernabei, MDCatholic University of Sacred Heart, Rome, ItalyAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-5-199609010-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We read with interest Dr. Smith's article on the diagnosis and treatment of pressure ulcers in the nursing home [1]. We agree that pressure ulcers are a multidisciplinary care problem and that the nursing staff plays a major role in coordinating systematic preventive interventions. However, both students and professionals working in health care hold negative attitudes toward aging and show much lower motivation for treating elderly patients than for treating younger patients. These attitudes may in turn influence the quality of the care provided to elderly patients. It may be argued that poor motivation and negative attitudes ...References1. Smith DM. Pressure ulcers in the nursing home. Ann Intern Med. 1995; 123:433-42. Google Scholar2. Rubenstein LZ, Wieland D, Bernabei R, eds. Geriatric Assessment Technology: State of the Art. Milan: Kurtis; 1995. Google Scholar3. Morris JN, Hawes C, Murphy K, Nonemaker S, Phillips C, Fries BE, et al. Resident Assessment Instrument Training Manual and Resource Guide. Natick, MA: Eliot Pr; 1991. Google Scholar4. Mor V. Effects of the nursing home resident assessment on process and outcome quality. Third European Congress of Gerontology, Amsterdam; 1995. Google Scholar5. Cipriani L, Landi F, Sgadari A, Zuccala G, Bernabei R. A gerontological continuing education programme: R.A.I. as a teaching tool for nursing home professionals. Educational Gerontology. 1995; 21:683-99. Google Scholar Author, Article, and Disclosure InformationAffiliations: Catholic University of Sacred Heart, Rome, Italy PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByIn vivo modeling of biofilm-infected wounds: A review 1 September 1996Volume 125, Issue 5Page: 422KeywordsAgingElderlyGeriatricsHealth careMotivationNursing homesPressure ulcersQuality improvementResearch quality assessmentRisk assessments Issue Published: 1 September 1996 CopyrightCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Placenta
Authors: Irwin H. Kaiser
Journal: JAMA (1968)

Publication of the<i>Handbuch</i>began in 1924 under the editorship of Henke of the University of Breslau and Lubarsch of the University of Berlin. It was planned as an encyclopedia in 14 volumes, each with several parts. The seventh volume, dedicated to the female reproductive tract, was initiated in 1930 with the classic section on uterus and tubes by Meyer and Frankl. By 1937, when the third and last part of the seventh volume was published, Meyer had entered a brief career as volume editor. Preparation of a fourth part, devoted to the placenta, vagina, and vulva, was announced at that time. Now, 30 years later, a separate section on placenta has been published, as part 5. The authors of a forthcoming fourth part, on vulva, vagina, and urethra, have been named. Thirty-six of the projected 43 sections have been published and 33 of these are still in print! The
BOOK REVIEW
Authors: M. T. KNOBF
Journal: JNCI Journal of the National Cancer Institute (1993)

BOOK REVIEW Get access Cancer Chemotherapy: A Nursing Process Approach Margaret Barton Burke , Gail M. Wilkes , Deborah Berg , Catherine K. Bean , Karen Ingwersen . Boston : Jones and Bartlett Publ. , 1991 . 466 pp., illus. $49.95. ISBN 086720-434-6 . M. TISH KNOBF, R.N., M.S.N. M. TISH KNOBF, R.N., M.S.N. Yale University School of NursingGEB, Rm.445, 25 Park St., New Haven, CT 06525 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 85, Issue 5, 3 March 1993, Page 408, https://doi.org/10.1093/jnci/85.5.408 Published: 03 March 1993
Apolipoprotein E E4 Allele and Risk of Dementia
Authors: Terho Lehtimaki
Journal: JAMA (1995)

<h3>To the Editor.</h3> —The association between apo E<i>E4</i>and AD has been shown in patients with probable AD and in autopsyconfirmed AD cases. However, the specificity of apo E<i>E4</i>as a risk factor for AD is not known. In a recent letter, Dr Frisoni and colleagues<sup>1</sup>proposed that the frequency of apo E<i>E4</i>is increased also in vascular dementia compared with that in controls. We analyzed apo E phenotypes in 30 patients with vascular dementia and 115 age-matched controls using isoelectric focusing and Western blotting as previously described.<sup>2</sup>Vascular dementia was diagnosed according to the guidelines established by the NINDS-AIREN International Workshop.<sup>3</sup>Seventeen patients with probable vascular dementia had a typical multi-infarct dementia. Possible vascular dementia was diagnosed in 13 patients, eight of whom were considered to have mixed dementia (ie, possible AD and concomitant significant cerebrovascular disease). No difference in apo E<i>E4</i>
Recombinant DNA
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Geriatrics
Authors: Paul B. Beeson
Journal: JAMA (1984)

Comparatively recently, health care providers in the United States have had to recognize that medical care for the nation's elderly, although an obligation great in scope and cost, does not fit easily into our established patterns of providing medical services. That the field of geriatric medicine needs clear definition is one facet of the ongoing controversies about who should look after old people, as well as how and where that function can best be carried out. Anyone who reads current articles in this field is likely to become somewhat bored by the sameness of the introductory paragraphs. Authors feel required to repeat well-known figures about the changing age of the population. American articles open by saying that in the United States more than 11% of the population is over the age of 65 years, and that the fastest growing segment of the entire population is the over-85s. This is followed
Ten-Year Stability of Depressive Personality Disorder in Depressed Outpatients
Authors: Rebecca Laptook
Journal: American Journal of Psychiatry (2006)

Objective: The purpose of this study was to examine the long-term stability of depressive personality disorder. Method: The subjects included 142 outpatients with axis I depressive disorders at study entry; 73 had depressive personality disorder. The patients were assessed by using semistructured diagnostic interviews at baseline and in four follow-up evaluations at 2.5-year intervals over 10.0 years. Follow-up data were available for 127 (89.4%) of the patients. Results: The 10.0-year stability of the diagnoses of depressive personality disorder was fair, and the rate of depressive personality disorder declined over time. The dimensional score was moderately stable over 10.0 years. Growth curve analyses revealed a sharp decline in the level of depressive personality disorder traits between the baseline and 2.5-year assessments, followed by a gradual linear decrease. Reductions in depressive personality disorder traits were associated with remission of the axis I depressive disorders. Finally, depressive personality disorder at baseline predicted the trajectory of depressive symptoms over time in patients with dysthymic disorder. Conclusions: Depressive personality disorder is moderately stable, particularly when assessed with a dimensional approach. However, the diagnosis rate and traits of depressive personality disorder tend to decline over time. The degree of stability for depressive personality disorder is comparable to that for the axis II disorders in the main text of DSM-IV. Finally, depressive personality disorder has prognostic implications for the course of axis I mood disorders, such as dysthymic disorder.
Similarity Between Mycoplasma And Bacterial L-forms Noted
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Treatise on Medicolegal Ophthalmology
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Proceedings of the British Thoracic Society
Authors: W Barsum, R Read, H Todd, A Rutman, R Wilson, Cole Host, Defence Unit, T Leigh, A Wakefield, W Cattell, J Collins, R Clifford, P Chetcuti, M Dunn, T Bailward, F Finlay, S Morris, F Carswell, K Meeran
Journal: Thorax (1991)

Unencapsulated non-typable Haemophilus influenzae (NTHi) form part of the normal nasopharyngeal flora and commonly infect the bronchial tree.Encapsulated H influenzae type b (Hib) less frequently colonise the nasopharynx, rarely infect the bronchial tree, but do cause serious systemic diseases-for example, meningitis in children.Possession of capsule reduces and possession of fimbriae enhances adherence of H influenzae to buccal epithelial cells.The majority of H influenzae in infected organ cultures of human respiratory mucosa are present in the mucus layer rather than at- 742P