tbuckley/cabot-search huggingface dataset:
Breast disease
Authors: J M. Dixon, R E Mansel
Journal: BMJ (1995)

and other details of the protocol.The effect of this adjustment was to reduce our estimated increase in mean dose-response ratio between 1982 and 1992.Until Booth and colleagues publish the details of their methods and their data, and until clinical data on the practical effects of differences between nebulisers are available, we suggest that our method of adjusting for methodological differences on the basis of our own epidemiological data was the most accurate adjustment that could be made.Using that adjustment, we found that the level of airway responsiveness had increased between 1982 and 1992 in both study regions.This finding, which supported our conclusions that the children studied in 1992 had a higher prevalence of airway hyperresponsiveness than the children studied in 1982, is consistent with other Australian studies that have reported a significant increase in the prevalence and severity of asthma.3
Contents
Authors: C.-Y Dai, W.-L Chuang, C.-K Ho, M.-Y Hsieh, J.-F Huang, L.-P Lee, N.-J Hou, Z.-Y Lin, S.-C Chen, L.-Y Wang, J.-F Tsai, W.-Y Chang, H Togashi, C Hashimoto, J Yokozawa, A Suzuki, K Sugahara, T Saito, I Yamaguchi, H Badawi, N Kainuma, M Aoyama, H Ohya
Journal: Journal of Hepatology (2008)
Authors' reply
Authors: A. C. C. Evers, H. A. A. Brouwers, C. W. P. M. Hukkelhoven, P. G. J. Nikkels, J. Boon, A. v. Egmond-Linden, J. Hillegersberg, Y. S. Snuif, S. Sterken-Hooisma, H. W. Bruinse, A. Kwee
Journal: BMJ (2010)
Deaths
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Protective Effect of a Single Interleukin-12 (IL-12) Predose Against the Toxicity of Subsequent Chronic IL-12 in Mice: Role of Cytokines and Glucocorticoids
Authors: Silvano Sacco, Hubertine Heremans, Berndt Echtenacher, Wim A. Buurman, Zoulikha Amraoui, Michel Goldman, Pietro Ghezzi
Journal: Blood (1997)
JAMA Reference Directories
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 5324: H3K9 histone methyltransferase G9a promotes lung cancer invasion and metastasis by silencing the cell adhesion molecule Ep-CAM
Authors: Min Wei Chen, Kuo-Tai Hua, Hsin-Jung Kao, Chia-Chun Chi, Lin-Hung Wei, Michael Hsiao, Min Liang Kuo
Journal: Cancer Research (2012)

Abstract G9a is a mammalian histone methyltransferase that contributes to the epigenetic silencing of tumor suppressor genes. Emerging evidence suggests that G9a is required to maintain the malignant phenotype, but the role of G9a function in mediating tumor metastasis has not been explored. Here, we show that G9a is expressed in aggressive lung cancer cells, and its elevated expression correlates with poor prognosis. RNAi-mediated knockdown of G9a in highly invasive lung cancer cells inhibited cell migration and invasion in vitro and metastasis in vivo. Conversely, ectopic G9a expression in weakly invasive lung cancer cells increased motility and metastasis. Mechanistic investigations suggested that repression of the cell adhesion molecule Ep-CAM mediated the effects of G9a. First, RNAi-mediated knockdown of Ep-CAM partially relieved metastasis suppression imposed by G9a suppression. Second, an inverse correlation between G9a and Ep-CAM expression existed in primary lung cancer. Third, Ep-CAM repression was associated with promoter methylation and an enrichment for dimethylated histone H3K9. G9a knockdown reduced the levels of H3K9 dimethylation and decreased the recruitment of the transcriptional cofactors HP1, DNMT1, and HDAC1 to the Ep-CAM promoter. Our findings establish a functional contribution of G9a overexpression with concomitant dysregulation of epigenetic pathways in lung cancer progression. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 5324. doi:1538-7445.AM2012-5324
THE MINIMAL REQUIREMENTS OF CALCIUM AND PHOSPHORUS IN CHILDHOOD
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Editorial Board
Authors: Stavroula Kousta, Katja Brose, Rolf Van Der Sanden, Patrick Scheffmann, Ria Otten, R Adolphs, R Baillargeon, N Chater, P Dayan, S Dehaene, D Dennett, J Driver, Y Dudai, A Engel, M Farah, A Friederici, O Hikosaka, R Jackendoff, P Johnson-Laird, N Kanwisher, M Kutas, N Logothetis, J Mcclelland, E Miller, R Poldrack, M Raichle, T Robbins, A Wagner, V Walsh, Ilia Karatsoreos, Bruce Mcewen, Behrad Noudoost, Tirin Moore, Jacob Bernstein, Edward Boyden, Michael Cohen, Katharina Wilmes, Irene Van De Vijver, Ned Block
Journal: Trends in Cognitive Sciences (2011)
Municipal drinking water and cardiovascular death rates
Authors: H. A. Schroeder
Journal: JAMA (1966)

The association of the degree of softness of municipal water and death rates from hypertensive and arteriosclerotic heart diseases, demonstrated for 1949 to 1951 rates, persisted in 1960. Statistical analyses of death rates from 88 cities of the United States with levels of bulk and trace elements in municipal water supplies showed negative correlations for 12 major and 4 trace constituents. The purer the water in terms of dissolved elements, the higher was the death rate from this cause. No trace element of 19 measured was found highly correlated. One possible explanation of this phenomenon involves the corrosive quality of soft water for metal pipes in dwellings.
A Novel Loss-of-Function Mutation, Gln459Arg, of the Calcium-Sensing Receptor Gene Associated with Apparent Autosomal Recessive Inheritance of Familial Hypocalciuric Hypercalcemia
Authors: Steven A. Lietman, Yardena Tenenbaum-Rakover, Tjin Shing Jap, Wu Yi-Chi, Yang De-Ming, Changlin Ding, Najat Kussiny, Michael A. Levine
Journal: Endocrine Reviews (2009)

Mutations that inactivate one allele of the gene encoding the calcium sensing receptor (CaSR) cause autosomal dominant familial hypocalciuric hypercalcemia (FHH), whereas homozygous mutations cause neonatal severe hyperparathyroidism. We describe the identification and biochemical characterization of a novel CaSR gene mutation that caused apparent autosomal recessive FHH in an extended consanguineous kindred. The study design involved direct sequence analysis of the CaSR gene, clinical and biochemical analyses of patients, and in vitro immunobiochemical studies of the mutant CaSR. A novel inactivating mutation (Q459R) was identified in exon 4 of both alleles of the CaSR in the proband, who presented with asymptomatic hypercalcemia and hypocalciuria at age 2 yr. The proband’s parents were heterozygous for the Q459R mutation consistent with autosomal recessive inheritance of FHH. Among 13 family members that were studied, eight subjects were heterozygous for the Q459R mutation and five had normal genotypes. All heterozygous subjects were asymptomatic and normocalcemic apart from one subject who was mildly hypercalcemic. The Q459R mutant CaSR was normally expressed at the cell membrane but retained only 30–50% of the calcium-dependent activity of the wild-type CaSR. We identified a novel loss-of-function Q459R mutation in the CaSR gene that exhibits mildly reduced sensitivity to calcium and that is associated with apparent autosomal recessive transmission of FHH. This study demonstrates the importance of genetic testing in FHH to distinguish between de novo and inherited mutations of the CaSR gene and assist in management decisions.
Anticardiolipin Antibodies and Hypercoagulability
Authors: Matthew H. Liang
Journal: Annals of Internal Medicine (1993)

Letters15 June 1993Anticardiolipin Antibodies and HypercoagulabilityMatthew H. Liang, MD, Charles H. Hennekens, MD, and Meir J. Stampfer, MDMatthew H. Liang, MDSearch for more papers by this author, Charles H. Hennekens, MDSearch for more papers by this author, and Meir J. Stampfer, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-118-12-199306150-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We appreciate the comments of Drs. Anand and Hess. The data cited by Dr. Anand [1] suggest that when treatment is warranted, warfarin may be more effective than aspirin in preventing recurrent thrombotic events in patients with elevated antiphospholipid antibody levels. As he notes, the study was not designed to study that treatment. In our study, physicians with such elevated levels who were assigned to aspirin did not appear to have a lower risk for thrombosis than those in the placebo group.Dr. Hess lists several potential reasons why we were not able to detect an association between ...References1. Rosove MH, Brewer PM. Antiphospholipid thrombosis: clinical course after the first thrombotic event. Ann Intern Med. 1992; 117: 303-8. Google Scholar2. Sletnes KE, Smith P, Abdelnoor M, Arnesen H, Wisloff F. Antiphospholipid antibodies after myocardial infarction and their relation to mortality, reinfarction, and nonhaemorrhagic stroke. Lancet. 1992; 339:451-3. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 June 1993Volume 118, Issue 12Page: 986-987KeywordsAcute myocardial infarctionAntibodiesAntibody productionAspirinDeep vein thrombosisIschemic strokeProspective studiesPulmonary embolismThrombosisTransient ischemic attacks Issue Published: 15 June 1993 CopyrightCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Medical News
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Carcinoembryonic antigen. A useful monitor of therapy of small cell lung cancer
Authors: R. H. Goslin
Journal: JAMA (1981)

In 85 patients with small cell cancer of the lung, the degree of carcinoembryonic antigen (CEA) elevation correlated with the extent of disease. Normal CEA levels (&lt;2.5 ng/mL) occurred in 55% of patients with limited disease compared with 12% of patients with extensive disease. All patients with CEA levels greater than 50 ng/mL had liver involvement. Serial CEA levels were useful in monitoring response to chemotherapy and in predicting relapse. All patients with CEA values greater than 5.0 ng/mL before start of treatment had a fall in CEA level with response to treatment and a rise in CEA level when resistance to chemotherapy developed. In patients with CEA levels of less than 5.0 ng/mL at the start of treatment, rising values reflected the onset of recurrent disease in 10 of 21 patients who had relapses. The CEA levels used in conjunction with standard roentgenograms and organ scanning studies can aid in the initial staging of small cell cancer of the lung, and in monitoring treatment. (<i>JAMA</i>1981;246:2173-2176)
Excessive Medication.
Journal: JAMA (1884)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
LONDON
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Letters to the Editor
Authors: Phillip W. Albro, Ann D. Latimer
Journal: Environmental Health Perspectives (1973)

A recent review by Dr. Mushak (1) dis- cusses several of the procedures used to an- alyze for organic mercurials by gas chroma- tography.He points out that there are several problems associated with these procedures, including halide exchange and decomposition on-column, and difficulty in unambiguously identifying the "peak" as being due to the compound expected.We feel that the techni- cal problems are more severe even than Dr. Mushak indicates, and would like to make available some of our observations.We have experimented with the FDA pro- cedure used by Drs.Kamps and Malone [derived from the various modifications of Wes- t6o's method (2-4)], the method developed by T. W. Beak Consultants, Ltd. (5), and a procedure recommended to us by Dr. Mushak (6).Our instrumentation was basically the same as that described by Baughman et al.
Chemistry and Toxicity of Flame Retardants for Plastics
Authors: R. Liepins, E. M. Pearce
Journal: Environmental Health Perspectives (1976)

An overview of commercially used flame retardants is give. The most used flame retardants are illustrated and the seven major markets, which use 96% of all flame-retarded polymers, are described. Annual flame retardant growth rate for each major market is also projected. Toxicity data are reviewed on only those compositions that are considered commercially significant today. This includes 18 compounds or families of compounds and four inherently flame-retarded polymers. Toxicological studies of flame retardants for most synthetic materials are of recent origin and only a few of the compounds have been evaluated in any great detail. Considerable toxicological problems may exist in the manufacturing of some flame retardants, their by-products, and possible decomposition products.
Clinical Dietetics: A Textbook for Physicians, Students and Dietitians.
Journal: Annals of Internal Medicine (1932)

in the construction of this ''framework,"' as he puts it.He does not pretend to give any exposition of the teachings of these schools, either descriptive or critical.He states his belief that psychopathology has some right to claim that it can provide a measure whereby we can evaluate the problems of the social, economic, political and religious realms, since psychopathology is the science of human motives and behaviour.Throughout the book are given notes of illustrative cases.These are considered and interpreted on a fairly superficial basis, but will no doubt prove interesting and instructive to such as have no psychiatric experience.The author resorts to a device that may have some' value if used with great care, namely, the construction of diagrams to represent the workings of mental mech- anisms.This device has been overworked here and might well have been omitted.Considering the present neglect of the psychological factor in medicine, the book might well be read by many medical men.However, it can have only a limited value for those who propose going deeply into the subje-t.It is a readable book and will probably appeal success- fully to the enquiring layman.
Fungus That Causes Histoplasmosis May Be Endemic in Montana
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal