tbuckley/cabot-search huggingface dataset:
Systematic Review of the Diagnosis and Management of Malignant Extradural Spinal Cord Compression: The Cancer Care Ontario Practice Guidelines Initiative‘s Neuro-Oncology Disease Site Group
Authors: D. Andrew Loblaw, James Perry, Alexandra Chambers, Normand J. Laperriere
Journal: Journal of Clinical Oncology (2005)

Purpose This systematic review describes the diagnosis and management of adult patients with a suspected or confirmed diagnosis of extradural malignant spinal cord compression (MSCC). Methods MEDLINE, CANCERLIT, and the Cochrane Library databases were searched to January 2004 using the following terms: spinal cord compression, nerve compression syndromes, spinal cord neoplasms, clinical trial, meta-analysis, and systematic review. Results Symptoms for MSCC include sensory changes, autonomic dysfunction, and back pain; however, back pain was not predictive of MSCC. The sensitivity and specificity for magnetic resonance imaging (MRI) range from 0.44 to 0.93 and 0.90 to 0.98, respectively, in the diagnosis of MSCC. The sensitivity and specificity for myelography range from 0.71 to 0.97 and 0.88 to 1.00, respectively. A randomized study detected higher ambulation rates in patients with MSCC who received high-dose dexamethasone before radiotherapy (RT) compared with patients who did not receive corticosteroids before RT (81% v 63% at 3 months, respectively; P = .046). There is no direct evidence that supports or refutes the type of surgery patients should have for the treatment of MSCC, whether surgical salvage should be attempted if patient is progressing on or shortly after RT, and whether patients with spinal instability should be treated with surgery. Conclusion Patients with symptoms of MSCC should be managed to minimize treatment delay. MRI is the preferred imaging technique. Treatment for patients with MSCC should consider pretreatment ambulatory status, comorbidities, technical surgical factors, the presence of bony compression and spinal instability, potential surgical complications, potential RT reactions, and patient preferences.
Gynecomastia in patients immobilized in spica casts
Authors: H. H. Kaminsky
Journal: JAMA (1969)

Breast enlargement developed in five patients being treated with spica casts. Examination of the tissue excised in each case revealed gynecomastia. Previous reports of a relationship between long-term immobilization and the development of gynecomastia could not be found. Although evaluation of these patients revealed hormonal abnormalities, the pathophysiology of the growths remains an enigma.
Needless Cancer Pain
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reducing black neonatal mortality. Will improvement in birth weight be enough?
Authors: N. J. Binkin
Journal: JAMA (1985)

To study some of the factors contributing to the higher rate of black neonatal mortality in the United States, we used matched cohort records for California between 1980 and 1981 and for Georgia between 1979 and 1981. We found that at any combination of birth weight and gestational age, black neonates weighing less than 3,000 g had lower mortality rates than whites, but this survival advantage was outweighed by considerably higher rates of low birth weight among blacks. At 3,000 g or more, whites had the survival advantage; even at optimal survival weight, the black mortality rate was nearly twice that for whites. If a reduction in the black mortality rate is to occur, improvements are needed both in the black birth-weight distribution and in birth-weight-specific mortality rates, particularly in the normal birth-weight ranges. (<i>JAMA</i>1985;253:372-375)
120P Survival outcomes of metastatic breast cancer who have been treated with bevacizumab and eribulin in the real world. - BEV 1 PTX followed by eribulin versus the reverse sequence
Authors: K. Matsui, M. Earashi, T. Nagata, A. Yoshikawa, W. Fukushima, Z. Nozaki, Y. Tanada, K. Oyama, K. Shimada, K. Kiyohara, T. Shimizu, K. Iwata, T. Yoshida, K. Maeda
Journal: Annals of Oncology (2016)
Incorrect Terminology
Authors: Steven Frucht, Michael Aminoff
Journal: JAMA Neurology (2018)

Henry D. Lather, BS; Heather L. Gornik, MD, MHS; Jeffrey W. Olin, DO; Xiaokui Gu, MA; Steven T. Heidt, BA; Esther S. H. Kim, MD, MPH; Daniella Kadian-Dodov, MD; Aditya Sharma, MBBS; Bruce Gray, DO; Michael R. Jaff, DO; Yung-Wei Chi, DO; Pamela Mace, RN; Eva Kline-Rogers, MS, RN, NP; James B. Froehlich, MD, MPH
THE DIFFERENTIAL DIAGNOSIS OF LEPROSY AND SYRINGOMYELIA.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ecotoxicology of Phenylphosphonothioates
Authors: B. Magnus Francis, Larry G. Hansen, T. Roy Fukuto, Po-Yung Lu, Robert L. Metcalf
Journal: Environmental Health Perspectives (1980)

The phenylphosphonothioate insecticides EPN and leptophos, and several analogs, were evaluated with respect to their delayed neurotoxic effects in hens and their environmental behavior in a terrestrial-aquatic model ecosystem. Acute toxicity to insects was highly correlated with sigma sigma of the substituted phenyl group (regression coefficient r = -0.91) while acute toxicity to mammals was slightly less well correlated (regression coefficient r = -0.71), and neurotoxicity was poorly correlated with sigma sigma (regression coefficient r = -0.35). Both EPN and leptophos were markedly more persistent and bioaccumulative in the model ecosystem than parathion. Desbromoleptophos, a contaminant and metabolite of leptophos, was seen to be a highly stable and persistent terminal residue of leptophos.
"Illegitimate" is not legitimate
Journal: JAMA (1977)

<h3>In Reply.—</h3> I thoroughly agree with Dr Beyer's view that medicine in this country is generally very good and that many physicians spend a great deal of time working on audit and tissue committees to further improve the quality of care in their hospitals. However, I do have a few relatively minor reservations about one of the examples given in his letter. Most surgeons see patients referred for an<i>opinion</i>regarding surgery rather than "for surgery," and it is part of our responsibility as consultants to dispute the diagnosis if we think surgery is inappropriate. We may be wrong in deciding not to operate, but it would certainly be irresponsible to operate solely to avoid disagreeing with the referring physician or out of an inordinate fear of ever being wrong by not operating. The conscientious exercise of surgical judgment not to operate often requires considerable courage; I am sure that
When the enemy is the environment, medical research may help provide effective defense
Authors: C. Raymond
Journal: JAMA (1989)

AT THE ARMY'S research center in Natick, Mass, the environment is the enemy. Investigators develop physiological, psychological, fitness, and nutritional strategies to help soldiers perform optimally in scorching heat, subzero chill, at high altitudes, and under chemical exposure. The US Army Research Institute of Environmental Medicine is located 27 kilometers west of Boston, yet its mission has taken researchers to Alaska, Egypt and the Tibetan Plateau. Field trips involve weeks of studying problems confronting soldiers on maneuvers in many environmental conditions. The institute's research has roots in laboratories set up just before World War II when the Army realized that no agency was studying how a soldier's performance might be affected by such stressful environments as the inside of a tank rolling across a desert. In 1942, the Secretary of War authorized establishment of the Armored Medical Research Laboratory at Fort Knox, Ky, to study acclimatization to heat, vision, nutrition,
Gastroplasty may lead field but it's not a winner yet
Authors: M. Korcok
Journal: JAMA (1981)

Of all surgical techniques used for the management of morbid obesity, gastric partitioning or gastroplasty has emerged in the opinion of some as the procedure of choice, leaving behind such precursors as ileocolic, jejunoileal, and gastric bypasses. But gastric partitioning (more popularly known as gastric stapling) too has spawned its own technical variants and problems and, according to a surgical team from the University of Ottawa, remains a "dangerous operation" with "far from ideal success" and "poorly documented" results. The report, presented by Alan J. Byrne, MD, research fellow in the Department of Surgery, University of Ottawa School of Medicine, at the 50th annual meeting of the Royal College of Physicians and Surgeons of Canada, indicates that although gastric partitioning is simpler than the earlier bypass modes, a number of complications occur, the most common of which are associated with staple disruption, pouch dilation, and stoma dilation. In a review
Presse Médicale, Paris
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Relief of continuous chronic pain by intraspinal narcotics infusion via an implanted reservoir
Authors: D. W. Coombs
Journal: JAMA (1983)

Ten patients with intractable pain (five cancer and five nonmalignant) were treated with continuous intraspinal morphine delivered by an implanted continuous infusion system. Both patient groups were evaluated and compared using an identical battery of psychometric examinations administered before and 12 weeks after therapy. The cancer-pain group reported significant reduction in pain on serial visual pain analogue scales at 12 weeks compared with no change in the nonmalignant-pain group reports despite a much lower baseline report in the cancer group. Both groups of patients reduced their oral narcotic requirement significantly during continuous intraspinal morphine infusion. While the cancer patients took more oral narcotic at baseline, at 12 weeks no difference existed in oral intake between the two groups. Both groups required significant serial increases in infused morphine, indicating that spinal opiate receptor tolerance occurs. The results of this study confirm the sustained analgesic efficacy reported earlier in cancer-related pain syndromes, thus supporting further cautious expansion of this therapy within the cancer-related pain population. In contrast, a poor response was seen in the nonmalignant-pain group, consistent with the unsatisfactory responses to many potentially analgetic approaches to chronic nonmalignant pain. We are thus discouraged from further use of this therapy in the patient with chronic nonmalignant pain. (<i>JAMA</i>1983;250:2336-2339)
A NOVEL Aurora A Kinase INHIBITOR MLN8237 Induces Cytotoxicity and CELL Cycle Arrest IN MULTIPLE MYELOMA.
Authors: Gullu Gorgun, Elisabetta Calabrese, Teru Hideshima, Jeffrey Ecsedy, Giada Bianchi, Mala Mani, Madhavi Bandi, Hiroshi Ikeda, Giulia Perrone, Yiguo Hu, Yu-Tzu Tai, Mei Zheng, Diana Cristea, Loredana Santo, Daniel R. Carrasco, Nikhil Munshi, Paul Richardson, Kenneth C. Anderson
Journal: Blood (2009)
Book Review Criteria for the Classification and Diagnosis of Heart Disease . By the Criteria Committee of the Heart Committee of the New York Tuberculosis and Health Association, Inc. (Joseph H. Bainton, M.D., Robert L. Levy, M.D., Arthur C. DeGraff, M.D., and Harold E. B. Pardee, M.D., Chairman.) Third Edition. Published by Tuberculosis and Health Association. 1932. New York.
Journal: New England Journal of Medicine (1933)
Book Review Lipidoses: Diseases of the cellular lipid metabolism . By Siegfried J. Thannhauser, M.D., Ph.D. Edited by Henry A. Christian, M.D., LL.D., Sc.D. (Hon.), F.R.C.P. (Hon., Can.). (Reprinted from Oxford Loose-Leaf Medicine.) 8°, cloth, 370 pp., with 78 illustrations. New York: Oxford University Press, 1940. $6.00.
Journal: New England Journal of Medicine (1941)
Clinical Efficacy of Daratumumab Monotherapy in Patients with Heavily Pretreated Relapsed or Refractory Multiple Myeloma
Authors: Saad Usmani, Brendan Weiss, Nizar J Bahlis, Andrew Belch, Sagar Lonial, Henk Lokhorst, Peter M. Voorhees, Paul G. Richardson, A Kate Sasser, Amy Axel, Huaibao Feng, Clarissa Uhlar, Jianping Wang, Imran Khan, Tahamtan Ahmadi, Hareth Nahi
Journal: Blood (2015)
A History of the Lycoming County Medical Society.
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Controlled study of streptococcal endocarditis--a problem of feasibility
Authors: R. Edelman
Journal: JAMA (1979)

<h3>In Reply.—</h3> In my opinion, letters of this type and quality are extremely important in the process of discovering the side effects of any new drug. Although timolol maleate had been extremely well studied before its release, it is only after such a drug has been on the market and has been used in thousands of patients that some of the less frequent side effects appear. Although case reports do not often prove cause and effect, they are important for pointing out circumstances in which more study is needed or where caution should be used. Suspected adverse effects such as are reported in Dr Shaivitz's letter should also be reported to the Food and Drug Administration (8800 Rockville Pike, Bethesda, MD 20205), the pharmaceutical company itself, and for adverse ocular side effects, National Registry of Drug Induced Ocular Side Effects (F. T. Fraunfelder, MD, Department of Ophthalmology, University of Oregon
The Preparation and After-Treatment of Section Cases.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Occupational Medicine
Authors: J. Wister Meigs
Journal: New England Journal of Medicine (1961)

Control through VaccinationThe Asian-influenza experience also gives evidence that known control measures, especially vaccination, were applied effectively among employed persons, often through well established occupational-health programs. Gottlieb59 vaccinated 94.3 per cent of 2893 employees at the Missile and Ordnance Systems Department of General Electric in Philadelphia. He used a 1-ml. dose of 200 chick-cell agglutination (CCA) units of monovalent vaccine against Asian influenza subcutaneously, and virtually completed all immunizations by September 22, 1957. Among those vaccinated 6.3 per cent had influenzalike symptoms and lost an average of two and two-tenths days per person. Unvaccinated persons had a 15.8 per . . .
No Long-Term Survivors
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ABC of major trauma. Radiological assessment--II.
Authors: M D Lewars, N M Perry
Journal: BMJ (1990)

Chest injuriesAbout 25% ofdeaths caused by major trauma are due to thoracic damage.The most useful radiograph in patients with thoracic trauma is the erect posteroanterior view.In the resuscitation room, however, the standard radiograph is often the supine anteroposterior view, which has the disadvantage of causing apparent enlargement of heart and mediastinal shadows, distending the upper lobe vessels, and making inspiration less efficient.In the supine position pleural air collects anteroinferiorly, outlining the diaphragm and heart, while pleu'ral fluid.-layersposteriorly give ill defined opacification of the hemithorax.Typical anteroposterior supine chest radiograph.There is poor inspiration and the upper lobe vasculature is prominent.The heart size is Poor inspiration as well as rotation of the magnified.patient with relation to the radiographic beam may result in artefactually abnormal appearances.Ideally, five anterior ribs and 10 Features shown in the initial chest radiograph posterior ribs should be counted above the level of the hemidiaphragm.The medial ends of the * Check for adequacy of inspiration, rotation of the patient, and artefacts of clavicles should be equidistant from the vertebral resuscitation r Ensusithation densityofeachhemithoraxisequaI spinous processes.* Ensure that the density of each hemithorax is equal The basic rules for assessment of the chest * Localised opacities may be pulmonary, pleural, artefactual, or on the chest radiograph are that the transverse diameter of the heart should not be greater than half the * Look for rib fractures.How many ribs are fractured and how many fractures transverse diameter of the thorax and that two thirds of the heart should lie to the left of the * Check the mediastinum for contour, width, and presence of gas I ~~~~~~~~~~~~~~~~midline. Vascular.distribution should be * Check the aortic knuckle for contour and definition symmetrical on each side, and each hemithorax * Look out for abnormal gas in the pleural, mediastinal, subcutaneous, and should have equal translucency.The hilar subphrenic spacesshadows should be clearly defined, with the left hilum being about 1-2 cm higher than the right.Cardiac, mediastinal, and diaphragmatic contours should be clearly outlined.* Pleural fluid also indicate an abdominal injury such as splenic or hepatic laceration, and Loss of aortic definition signs of subdiaphragmatic air from a visceral perforation should be sought min the chest radiograph.