tbuckley/cabot-search huggingface dataset:
Effects of Acute Angiotensin II Type 1 Receptor Antagonism and Angiotensin Converting Enzyme Inhibition on Plasma Fibrinolytic Parameters in Patients With Heart Failure
Authors: Nicholas E. R. Goodfield, David E. Newby, Christopher A. Ludlam, Andrew D. Flapan
Journal: Circulation (1999)

Background —Angiotensin converting enzyme (ACE) inhibition after myocardial infarction is associated with an improvement in plasma fibrinolytic parameters. The aim of the present study was to determine whether acute ACE inhibition and angiotensin II type 1 (AT 1 ) receptor antagonism have similar effects in patients with heart failure. Methods and Results —Twenty patients with moderately severe chronic heart failure received enalapril 10 mg and losartan 50 mg on 2 separate occasions in a single-blind, randomized, crossover design. Plasma tissue plasminogen activator (t-PA) and plasminogen activator inhibitor type 1 (PAI-1) antigen and activity were measured at baseline and 6 hours after the dose. Acute administration of losartan but not of enalapril reduced plasma t-PA (11%; P =0.003) and PAI-1 (38%; P &lt;0.001) antigen concentrations, which was associated with increases in t-PA (29%; P =0.03) and decreases in PAI-1 (48%; P =0.01) activity. Changes in plasma fibrinolytic parameters were more marked during losartan treatment ( P &lt;0.02), with a 3-fold greater reduction in plasma PAI-1 antigen concentrations ( P &lt;0.05). Conclusions —Acute AT 1 antagonism in patients with heart failure is associated with a significant improvement in plasma fibrinolytic parameters that is greater than during ACE inhibition. These beneficial effects of AT 1 antagonism and ACE inhibition would therefore appear to be mediated principally through suppression of angiotensin II.
Health USA
Authors: Mary Jo Jacobs
Journal: JAMA (1992)

<h3>To the Editor.</h3> —Dr Brown and colleagues<sup>1</sup>are to be commended for the comprehensive national health program developed for Sen Bob Kerrey (D, Neb). Its special value in moving forward the discussion of health care reform is its attention to the provision of how to finance such a change, which is sadly lacking in many previous proposals, including the Pepper Commission report. Not clear, however, in Brown's description, and leaving the reader wondering, is attention to the role of the National Health Care Commission. Our nation's previous experience with health delivery, "administered by the states under federal guidelines and with strong federal financial support" (Medicaid), has been a disaster to state budgets, resulted in drastic underpayment to all providers, and has been drastically unequal in benefits to recipients, depending on their state residency. The recent battle between the Health Care Financing Administration and the unusual coalition of Congress and
Molecular basis for Rhnull syndrome: Identification of three new missense mutations in the Rh50 glycoprotein gene
Authors: Cheng‐Han Huang, Guangjie Cheng, Zhi Liu, Ying Chen, Marion E. Reid, Gregory Halverson, Yasuto Okubo
Journal: American Journal of Hematology (1999)

Rh null is a rare autosomal recessive disorder characterized by an absence of Rh antigens and a varying degree of hemolytic anemia and spherostomatocytosis.We report studies of two Japanese Rh null cases and describe three new missense mutations of RHAG, the locus that encodes Rh50 glycoprotein and modulates Rh antigen expression.In Rh null (HT), RHAG harbored in exon 6 two G→A transitions, GTT→ATT and GGA→AGA, which cause Val 270 →Ile and Gly 280 →Arg substitutions, respectively.These missense mutations were cotransmitted from the propositus to the children and were predicted to reside in endoloop 5 and transmembrane (TM) segment 9, respectively.In Rh null (WO), RHAG contained in exon 9 a single G→T transversion, GGT→GTT, which caused a Gly 380 →Val missense change in TM12 segment.The G→T transversion, which is located at the +1 position of exon 9, had also affected pre-mRNA splicing and caused partial exon skipping.Although both Rh null cases had a structurally normal RH antigen locus, hemagglutination and immunoblotting showed no expression of Rh antigens or proteins.These results correlate each mutation with a structural defect in the respective TM domain of Rh50 glycoprotein.Am.
The threat of biological weapons. Prophylaxis and mitigation of psychological and social consequences
Authors: H. C. Holloway
Journal: JAMA (1997)

The microbial world is mysterious, threatening, and frightening to most people. The stressors associated with a biological terrorist attack could create high numbers of acute and potentially chronic psychiatric casualties who must be recognized, diagnosed, and treated to facilitate triage and medical care. Media communications, planning for quarantine and decontamination, and the role of community leaders are important to the mitigation of psychological consequences. Physicians will need to accurately diagnose anxiety, depression, bereavement, and organic brain syndromes to provide treatment, reassurance, and the relief of pain.
Triiodothyronine in Advanced Breast Cancer
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE CONFERENCE ON ECONOMIC SECURITY
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Contributions to a New Chapter in the Physiology and Pathology of the Nervous System
Authors: T. Laycock
Journal: BMJ (1868)

THE diseases and disorders of the nervous system which result from un- natural and excessive sexual excitement, whether of mind or of body, or both, are of the most varied character, because there is no portion of the nervous system which may not be thus morbidly influenced.This is a fact of fundamental importance.The ends aimed at in the processes of reproduction are, the maintenance of the species, and, as re- gards man at least, the perfection of the race, according to the laws of evolution which regulate all the reproductive processes and domestic and social instincts of the highest and lowliest organisms alike.These are most highly evolved in the relations of the sexes in man.If, from this point of view, we consider even superficially the highest pathological phenomena of this kind-such, e.g., as are detailed by Mr. Hepworth Dixon in his book entitled Spiritual Wives-we cannot but con- clude that a thoroughly comprehensive theory of the cerebro-mental changes that coincide with these higher sexual and social relations must bring the fundamental laws of reproduction into correlation with as fundamental principles of natural religion, morals, art, politics, and so- cial science.Hitherto this department of practice has been so restricted in scope and so neglected, that phenomena like those detailed by Mr.
Abstract MP034: Adiponectin Concentrations are Inversely Associated with Risk of Peripheral Arterial Disease in Men
Authors: Michel M Joosten, Kaumudi J Joshipura, Jennifer K Pai, Monica L Bertoia, Eric B Rimm, Murray A Mittleman, Kenneth J Mukamal
Journal: Circulation (2012)

Background: Lower concentrations of adiponectin have been linked to the development of occlusive coronary events in otherwise healthy individuals. Whether similar relationships exist for the development of systemic atherosclerosis, such as peripheral arterial disease (PAD), is unknown. Methods: We used data from a prospective, nested case-control study among 18,225 male participants of the Health Professionals Follow-up Study aged 40 to 75 years who were free of diagnosed cardiovascular disease at the time of blood draw (1993–1995). During 14 years of follow-up through January 31, 2008, 143 men developed PAD. Using risk set sampling, controls were selected in a 3:1 ratio matched for age, date of blood draw, fasting status and smoking status (n=429). We used conditional logistic regression models to assess PAD risk. Results: Higher adiponectin concentrations were associated with a lower risk of PAD (Odds ratio [OR] per SD increase 0.58; 95% confidence interval [CI], 0.45–0.75) after controlling for pack-years of smoking, type 2 diabetes, hypertension, family history of myocardial infarction, aspirin use, body mass index and physical activity. Additional adjustment for low- and high-density lipoprotein cholesterol and high-sensitivity C-reactive protein concentrations attenuated the association (OR per SD increase, 0.71; 95% CI, 0.54–0.95). Further adjustment for hemoglobin A 1c , triglyceride, and gamma-glutamyltransferase concentrations did not alter the results. A log-linear inverse dose-response relationship was evident over the full spectrum of total adiponectin concentrations ( P trend =0.02; Figure). Conclusion: Total adiponectin concentrations are inversely associated with risk of PAD in otherwise healthy men. This relationship can only partly be explained by cholesterol and C-reactive protein concentrations and is independent of triglycerides and glycemic status. Figure legend: Dose-Response Relationship between Total Adiponectin Concentrations and Odds Ratio of PAD.
THE PERIODIC PHYSICAL EXAMINATION IN YOUTH
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SPOROTRICHOSIS
Authors: FRANK W. CREGOR
Journal: JAMA (1922)

In instituting control measures against the relapsing fever of Panama and Tropical America, cognizance must be taken of these facts, and efforts must be made toward the elimination of the tick not only in habita¬ tions, but also on the rat, and elimination of the rat as well.For it will be impossible to control an outbreak of the disease if one of the important agencies in its dissemination is disregarded through failure to attack the tick in the nymphal stage on the.rat.International Health Board..
Pancreatic Cancer Survival Increases with Chemo Combo
Journal: Cancer Discovery (2016)

Abstract For patients able to have surgery for pancreatic cancer, the adjuvant use of gemcitabine plus capecitabine, instead of gemcitabine alone, leads to a significant improvement in 5-year survival, according to results of the ESPAC-4 trial. The finding will likely change the standard of care for these patients.
Reply:
Authors: Dhiraj Tripathi, Peter C. Hayes
Journal: Hepatology (2009)

Thank you for responding to our study,1 which is in line with all other trials of primary prophylaxis for the prevention of variceal bleeding in selection of patients with grade II or larger varices.2 Indeed, we recommend caution in performing band ligation in patients with smaller varices, as highlighted by a recent study.3 This demonstrated a high incidence of banding-related bleeding when patients with smaller varices were included. In our study, none of the patients had red signs at endoscopy, but it is not clear whether patients without red signs should be excluded from band ligation. A recent study comparing propranolol with variceal band ligation for primary prevention reported fatalities due to banding-related ulceration despite all patients having red signs.4 Banding-related bleeding occurred at the second banding session in all patients in our trial, and in these patients there was no difference in the banding schedule compared with other patients. We believe variceal band ligation remains an option for primary prophylaxis, but careful selection of patients with high-risk varices is essential. We observed a low eradication rate, and we would respond by saying that our trial reflects what is likely to be the real-life situation in a patient with predominantly alcoholic liver disease. Compliance was an issue in our trial, in particular with patients in the banding arm. We performed a separate per-protocol analysis where the eradication rate was much higher at 73%, and did not demonstrate differences in the outcomes. We highlight the importance of eradication of varices and adhering to banding schedules. Drug therapy clearly has advantages here, because the protective effect is immediate and carvedilol therapy is particularly attractive because there is no need to titrate with the resting pulse, dosing is once daily, and the side effect profile appears to be better than with propranolol. Comparing carvedilol only with patients who have had varices eradicated would seem ideal, but in practice in the vast majority of compliant patients eradication of varices is possible. We observed secondary gastric varices in 19% of patients in the banding arm, and none of these patients bled from gastric varices.1 Patients in the carvedilol arm did not undergo routine endoscopies after randomization. Clearly, there is a risk of the development of gastric varices with variceal band ligation, but at least in our follow-up period there did not seem to be clinical complications. A longer follow-up and a larger number of patients would be required to study this group of patients. Dhiraj Tripathi M.D., M.R.C.P.*, Peter C. Hayes M.D., Ph.D., F.R.C.P. , * Liver Unit, Queen Elizabeth Hospital, Edgbaston, Birmingham, UK, Department of Hepatology, Royal Infirmary of Edinburgh, Edinburgh, UK.
Diagnostic tests for silicone breast disease. From the Centers for Disease Control
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Helical Fracture
Authors: Carl L. Gillies
Journal: JAMA (1961)

<h3>To the Editor:—</h3> InThe Journalof March 4, 1961, p. 823, Leo Eloesser, M.D., contends that the fracture illustrated in "Fracture of the Month No. 4, Tibia and Fibula" (<i>JAMA</i><b>174</b>:1191 [Oct. 29] 1960) should be termed a spiral and not an oblique fracture. Otto E. Aufranc, M.D., in his reply says in part, "If these discussions do nothing else other than purify our language and our manner of discussing these cases, they will have accomplished a great deal." With this noble goal in mind I feel obliged to say that while oblique, spiral, and helical have often been used interchangeably to describe this type of fracture produced by torsion, I am in complete agreement with Bonnin (<i>Injuries to the Ankle</i>, J. Grant Bonnin, New York: Grune &amp; Stratton, 1950, p. 400) who says: "Helical is the correct term, spiral implying that the curve lies in one plane."
Vertebral Artery Insufficiency
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AGING IN THE DIABETIC
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A field trial of inactivated measles virus vaccine in young school children. Protection during 27 months of follow-up
Authors: W. Winkelstein
Journal: JAMA (1965)

A concentrated, alum-containing, formalin-inactivated measles virus vaccine was evaluated in a double-blind field trial conducted in young school children. Vaccine was administered at random to 296 five- and six-year olds and placebo to 286. The dosage schedule consisted of three intramuscular injections of 0.5 ml of vaccine or placebo at intervals of one and three weeks. Measles was prevalent in the study population during the immunization period and for three months thereafter as well as from the 18th through the 27th months of follow-up. During the immediate postvaccir ation challenge vaccine effectiveness was estimated at 94% while during the late postimmunization challenge, effectiveness had declined to 57%. Nevertheless, during the latter period, the proportion of mild cases was considerably higher among vaccinees than controls.
Young Male Prostitutes
Authors: Patrick Gandy
Journal: JAMA (1970)

The physician can become a significant person in the recognition and job rehabilitation of the young male prostitute. The investigation of the lives of 50 individuals engaged in prostitution to homosexuals in an urban area revealed patterns of behavior unlike those of other groups alienated from society. The rejection of the authors' early attempts at interviewing these youths led to the development of the skills needed to reach these young men in order to provide vocational rehabilitation and to make other efforts to meet their real need, a worthwhile existence in every aspect of their lives.