tbuckley/cabot-search huggingface dataset:
Cholera.
Journal: JAMA (1883)

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Medical Economics
Journal: JAMA (1926)

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Reminiscences of George Martin Kober, M.D., LL.D., Emeritus Dean and Professor of Hygiene of the School of Medicine and Member of the Board of Regents, Georgetown University, Washington, D. C. (In Two Volumes.) Volume I.
Journal: JAMA (1930)

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Modulated Gap Junctional Intercellular Communication as a Biomarker of PAH Epigenetic Toxicity: Structure-Function Relationship
Authors: Brad L. Upham, Liliane M. Weis, James E. Trosko
Journal: Environmental Health Perspectives (1998)

Cancer is a multistage multimechanism process involving gene and/or chromosomal mutations (genotoxic events), altered gene expression at the transcriptional, translational, and posttranslational levels (epigenetic events), and altered cell survival (proliferation and apoptosis or necrosis), resulting in an imbalance of the organism's homeostasis.Maintenance of the organism's homeostasis depends on the intricate coordination of genetic and metabolic events between cells via extracellular and intercellular communication mechanisms.The release of a quiescent cell, whether normal or premalignant, from the suppressing effects of communicating neighbors requires the downregulation of intercellular communication via gap junctions, thereby allowing factors that control intracellular events to exceed a critical mass necessary for the cell to either proliferate or undergo apoptosis.Therefore, determining the role an environmental pollutant must play in the multistage carcinogenic process includes mechanisms of epigenetic toxicity such as the effects of a compound on gap junctional intercellular communication (GJIC).A classic example of a class of compounds in which determination of carcinogenicity focused on genotoxic events and ignored epigenetic events is polycyclic aromatic hydrocarbons (PAHs).The study of structure-activity relationships of PAHs has focused exclusively on the genotoxic and tumor- initiating properties of the compound.We report on the structure-activity relationships of two-to four-ringed PAHs on GJIC in a rat liver epithelial cell line.PAHs containing a bay or baylike region were more potent inhibitors of GJIC than the linear PAHs that do not contain these regions.These are some of the first studies to determine the epigenetic toxicity of PAHs at the epigenetic level.
Herbal Medicines
Journal: JAMA (1999)

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伊赛珠单抗在中度至重度生殖器银屑病中的疗效和安全性
Authors: C. Ryan, A. Menter, L. Guenther, A. Blauvelt, R. Bissonnette, K. Meeuwis, J. Sullivan, J.C. Cather, G. Yosipovitch, A.B. Gottlieb, J.F. Merola, K. Callis Duffin, S. Fretzin, O.O. Osuntokun, R. Burge, A.N. Naegeli, F.E. Yang, C.-Y. Lin, K. Todd, A. Potts Bleakman
Journal: British Journal of Dermatology (2018)

银屑病是一种常见的皮肤病,影响全世界约 2% 的人。它呈现出红色、鳞状和经常发痒的斑块, 可以影响身体任何部位的皮肤。大约 63% 的患者在其疾病过程中的某个时间点在生殖器区域患有银屑病。生殖器银屑病很难治疗, 它可能是一种特别疼痛、发痒、不舒服和令人尴尬的银屑病形式。它还会导致个人关系、性健康和整体生活质量的困难。本研究旨在确定用于治疗一般银屑病的伊赛珠单抗是否也能成功治疗生殖器银屑病。来自多个全球国家的生殖器银屑病患者接受了伊赛珠单抗或安慰剂(缺乏活性药物的假注射)治疗。在 12 周治疗期间, 使用临床工具组合测量生殖器银屑病严重程度以及患者完成的关于其生殖器银屑病对其生活质量和性健康的影响的问卷调查, 将伊赛珠单抗的效果与安慰剂进行比较。伊赛珠单抗在生殖器银屑病严重程度方面提供了更大的改善, 在第 12 周时超过 73% 的患者具有极少或没有生殖器银屑病且 56% 的患者没有生殖器银屑病。伊赛珠单抗的作用很快,早在治疗的第一周就观察到了明显的改善。生殖器瘙痒的严重程度和生殖器银屑病对性活动频率的影响也有了迅速和更大的改善。该研究表明, 伊赛珠单抗是治疗生殖器银屑病的有效方法。
COCCYGEAL HERNIA
Authors: Gustav A. Pagenstecher
Journal: JAMA (1930)

Herniation of the abdominal viscera is found in every direction. The usual types of hernia are most frequently due to some congenital malformation or weakness. Hernias through the pelvic floor are uncommon and are due in the main to mechanical injury after birth. In spite of the fact that the greater part of the hydrostatic pressure of the abdominal viscera is exerted on the pelvic floor, the strong but short pelvic fascia, aided by the sacrum, coccyx, pubic rami, sacrosciatic ligament, sacrotuberous ligament, urogenital ligament, levator ani and gluteus maximus muscles are able to hold the viscera back and prevent them from extruding through its vaginal and anal openings, making a hernia in this region one of the rarest of protrusions. A woman, aged 50, came to me complaining of a pain in the region of the coccyx which was aggravated by sitting, coughing or straining at stool. This pain
Medical staff organization and administration
Authors: R. E. Toomey
Journal: JAMA (1967)

In our society today, the medical staff of a voluntary nonprofit hospital is an organizational anomaly. The individual physicians in most communities are private entrepreneurs. They establish a private practice in any location in the community that they want. They determine for themselves exactly what services they will provide in their own office. Their existence in their own office practice is relatively uncomplicated and unregulated. However, physicians are considered part of a profession that has both moral and social obligations to the community in which they live. Because of this, they must participate in activities affecting the entire community and not just that portion they see in their private office. From the beginning, physicians live in a dichotomous world. The first aspect of the dichotomy is expressed in their private office practice. The second facet is expressed in their use of the hospital. It is in the hospital setting that
Transient telomere dysfunction induces chromosomal instability and promotes carcinogenesis
Authors: Yvonne Begus-Nahrmann, Daniel Hartmann, Johann Kraus, Parisa Eshraghi, Annika Scheffold, Melanie Grieb, Volker Rasche, Peter Schirmacher, Han-Wong Lee, Hans A. Kestler, André Lechel, K. Lenhard Rudolph
Journal: Journal of Clinical Investigation (2021)

In some figures, sample sizes were omitted or incorrectly stated.Data shown in Figure 2, A-C, and Supplemental Figure 5, A-C, were from the same experiment, which, as indicated, included male and female mice.The correct sample sizes for those figures are as follows: male mice: TTD + liver, n = 3; TTD + HCC, n = 5; TTD -liver, n = 5; TTD -HCC, n = 6; G3 HCC, n = 5; female mice: TTD + liver, n = 6; TTD + HCC, n = 5; TTD -liver, n = 6; TTD -HCC, n = 4.The correct sample sizes for Figure 3E are as follows: TTD + liver, n = 7; TTD + HCC, n = 4; TTD -liver, n = 12; TTD -HCC, n = 11; G3 HCC, n = 5.The correct sample sizes for Supplemental Figure 5D are as follows: TTD + , n = 5; TTD -, n = 3; G3, n = 5.The correct sample sizes for Supplemental Figure 8, C and D, are as follows: n = 4 per group.Supplemental Figure 5D showed error bars as SD instead of SEM, as stated in Methods, and there were errors in the depictions of P values.Both are corrected the revised Supplemental Figure 5D, which is shown below and has been replaced in the supplemental data file.In Supplemental Figure 1E, Western blots for detecting TRF2 ΔBΔM and GAPDH were run on separate gels using the same lysates.
Operative Surgery for Students and Practitioners
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
New Year
Authors: Sherko Bekas
Journal: Annals of Internal Medicine (1997)

Ad Libitum15 May 1997New YearSherko BekasSherko BekasThe Secret Diary of A Rose: A Kurdish Anthology of Poems.Translated by Shirwan Mirza, MD, University of Vermont, Burlington, VT 05405.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-126-10-199705150-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail I will ask for their hands ... Author, Article, and Disclosure InformationAuthors: Sherko BekasAffiliations: The Secret Diary of A Rose: A Kurdish Anthology of Poems.Translated by Shirwan Mirza, MD, University of Vermont, Burlington, VT 05405.Corresponding Author: Shirwan Mirza, MD, 220 Riverside Avenue, Apt. D5, Burlington, VT 05401.Corresponding Author: Shirwan Mirza, MD, 220 Riverside Avenue, Apt. D5, Burlington, VT 05401. Previousarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 May 1997Volume 126, Issue 10 Page: 825-826 Keywords Ants Sleep ePublished: 15 August 2000 Issue Published: 15 May 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Hormone replacement therapy and breast cancer risk
Authors: C. Campagnoli
Journal: JAMA (1996)

<h3>In Reply.</h3> —Epidemiological data on the association between HRT and breast cancer risk still seem contradictory, both when comparing results of studies from within the United States and studies from the United States and Europe.<sup>1-3</sup>Differences in design qualities and in study populations may be important explanations. The comments of Dr Harris and colleagues and Dr Campagnoli and colleagues, however, focus attention on biological mechanisms that might explain why HRT in some circumstances may exert an adverse effect on breast cancer risk. On the basis of subgroup analyses from several studies, Harris et al suggest that, compared with women with normal BMIs, the breast tissue in lean women is exposed to higher concentrations of estrogens, and therefore it may particularly susceptible. It might also be that exogenous hormones have a greater impact in lean women because they have relatively lower endogenous levels before treatment. The breast tissue may be
Pulse
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Values in Nature and in Psychotherapy
Journal: JAMA (1963)

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Emporiatric policy and practice. Protecting the health of Americans abroad
Authors: J. M. Mann
Journal: JAMA (1983)

INTERNATIONAL travel must be salutary, for otherwise why would more than one-quarter billion people spend nearly $100 billion (projections for the mid-1980s<sup>1</sup>) to visit foreign lands? However exhilarating international travel may be, such travelers also encounter a variety of potential health hazards, cogent reminders of the major biologic, social, and physical differences between their home countries and the regions to which they journey. Particular concern arises when travelers leave a highly industrialized nation like the United States and voyage to third-world and developing countries. Emporiatrics, the science of the health of travelers,<sup>2</sup>seems especially likely to benefit US travelers to developing areas, as the enormous differences between home and foreign environments necessitate special measures to protect travelers' health. In addition, these US travelers may be especially susceptible to unappreciated dangers because most Americans are unthinkingly accustomed to safe water, food, and swimming areas, view mosquitoes and dog bites as
Erratum
Authors: A Allen, Brandon Areher, ) Anderson, A Aristides, P Allen, J London, J Braithwaite, Brighton Blaker, M Biegs, S Browne, G Basliford, Cox Tindall, London Bidwell, ; Clanrye, L Caractacus, London Canney, Miss Corthorn, W Campbell, C Mr, ] Saddlewortb, London Cautley
Journal: BMJ (1901)
Role of Genotoxic and Nongenotoxic Effects in Multistage Carcinogenicity of Aromatic Amines
Authors: Hans-Gunter Neumann, Roland Hammerl, Wolfgang Hillesheim, Michael Wildschutte
Journal: Environmental Health Perspectives (1990)

It has been demonstrated in several model systems that tumors arise in a multistage process. Carcinogenic aromatic amines are complete carcinogens, which usually produce tumors in typical target tissues without any additional treatment. The tissue specificity, however, cannot readily be explained by genotoxic effects, and the role of secondary effects is not well understood. Promotional pressure on initiated cells can be produced by endogenous factors but also by the chemical itself. Comparison of the effects on rat liver of 2-acetylaminofluorene (AAF) and trans-4-acetylaminostilbene (AAS) provides some evidence that initiating and promoting properties of these chemicals can be separated. AAS is a strong initiator in rat liver but seems to lack promoting activity; AAF is a less efficient initiator but has tumor promoting properties. The results obtained so far indicate that promoting pressure is not produced by the acute, cytotoxic effects of AAF. It is therefore concluded that nongenotoxic, possibly receptor-mediated effects are involved.
THE "RECOGNITION" OF MEDICAL COLLEGES.
Journal: JAMA (1897)

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Thyroid
Authors: M. N. Maisey
Journal: Clinical Nuclear Medicine (1998)

The prevalence of diseases of the thyroid is high. In 1956, Perlmutter and Slater [1] estimated that 4–12% of the population of the USA had palpable thyroid nodules of which 2–5% were probably malignant. In a population study of north-east England, Tunbridge et al. [2] reported that in adult females, the prevalence of hyperthyroidism was 1.9–2.7%, of overt hypothyroidism 1.4–1.9%, of subclinical hypothyroidism 7.5%, and of non-toxic goitres 8.6%; however, the prevalence of these conditions was much lower in males. The classification of thyroid diseases is shown in Table 10.1.
Intraocular Fluid Dynamics in Retinal Detachment
Journal: JAMA (1963)

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