tbuckley/cabot-search huggingface dataset:
Journal of Surgical Research, Philadelphia
Journal: JAMA (1970)

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Reply
Authors: Michael Wang
Journal: American Journal of Hematology (2006)

To the Editor: Granulocytic sarcoma, a localized tumor mass composed of immature cells derived from the hematopoietic myeloid series, could infiltrate any extramedullary site; however, mediastinal involvement is distinctly rare [1].A patient who presented cardiac tamponade and superior vena cava obstruction caused by granulocytic sarcoma is described.A 45-year-old woman presented with a 1-month history of general discomfort, anorexia, and pain on the left costosternal zone.The chest X-ray was normal.Four weeks later, dyspnea appeared on moderate effort.On admission, she had orthopnea, elevated jugular venous pressure, regular tachycardia, normal blood pressure, distant heart sounds, and bilateral leg swelling.Hepatomegaly and lympha-denopathy were absent.Chest X-ray now showed an enlarged cardiac silhouette and a moderate right pleural effusion.Electrocardiogram showed sinus tachycardia and low voltage.Laboratory test showed a haemoglobin level of 80 g/L, and ESR of 62 mm/hr.There were no abnormal cells.Thoracocentesis showed an inflammatory exudate with absence of malignant cells.On the fifth hospital day, the patient had increased dyspnea, marked distension of jugular venous, Kuss-maul sign, pulsus paradoxus of 20 mmHg, and hypotension.An echocardiogram disclosed a large pericardial effusion with cardiac tamponade (Fig. 1), and 750 mL of bloody fluid was removed.Pericardial fluid and biopsy were negative for malignancy.A full-body CT scan showed (Fig. 2) findings highly suggestive of thoracic lymphoma and a superior vena cava obstruction.Bone marrow biopsy was normal.A mediastinum biopsy revealed a granulocytic sarcoma.Immunophenotypic analysis of the blasts showed positive cytoplasmic staining for myeloid markers (MPO), CD34 þ , CD68 þ , and HLA-DR þ .Cytogenetic analysis revealed following karyotype: þ4, -9, -17, add (17)(p13), -18, þ21, þ22.The disease remained refractory to chemotherapy (idarubicin, cytarabine, and hydroxyurea), and the patient expired in multiorgan failure, 13 weeks after clinical onset.Granulocytic sarcoma can infiltrate different organs, including bone, skin, lymph nodes, lung, breast, and central nervous system.Mediastinal involvement in hematological malignancy is always considered exclusively of lymphoid origin [2].However, a few reports of mediastinal granulocytic sarcoma with features of superior vena cava obstruction have been described [2,3].Malignant involvement
Simulation of ectopic ventricular rhythms by aberrant conduction
Authors: H. J. Marriott
Journal: JAMA (1966)

The electrocardiogram is indispensable for unravelling complex arrhythmias. Yet the tracing can lead the uninformed astray in the presence of the simplest disturbances of rhythm. Aberrant ventricular conduction is a common occurrence and it is the basis for much arrhythmic confusion. What looks ventricular in origin is not necessarily so; and although the philosophy "Why diagnose when you can convert?" is spreading in this age of electric miracles, more thoughtful therapists still know that there are practical as well as intellectual advantages in knowing what tachyrhythm confronts them. When a descending impulse reaches the ventricular conducting system and finds part of it blocked or refractory, the impulse is forced to travel by a devious route and writes an anomalous QRS complex. If this state of affairs is more or less permanent and the QRS-T pattern is characteristic, we call the disturbance "bundle-branch block." If, however, the alteration in the QRS
Rationing Medicine
Authors: Ronald M. Andersen
Journal: JAMA (1988)

Physicians have a major stake in the subject of this book: "rationing medicine." As those who pay for medical services, including the government, employers, and the public at large, become increasingly convinced that we are spending too much on medical care, there is more and more talk about the need to "ration medicine." Of course, the physician, as the major care giver in our system, has always been involved in rationing plans. What is changing, as author Robert Blank points out, is the nature of this rationing: Physicians always have made rationing decisions on a case-by-case basis at the bedside or in the hospital administrator's office, but not under government pressure in a systematic institutionalized manner. Their central commitment has been to the patient, not to society, and the current shift toward public allocation is a clear threat to medical ethics. (p 129) Further compounding the ethical problem for physicians
Sarcoidosis
Authors: David G. Freiman
Journal: New England Journal of Medicine (1948)

Bone. Localization of the sarcoid lesions in bone has frequently been described, but the true incidence of such involvement is not known. The incidence of roentgenographically demonstrable involvement, however, has ranged between 15 and 25 per cent of cases in several series5, 38, 49, 131; in others it has been considerably lower,45, 132 and only 1 case of such involvement has been reported from Australia.118 The tendency of the lesions to appear at any time, to last for indefinite periods, to regress spontaneously and even to reappear at a later date44 makes it necessary to follow cases for an adequate period by . . .
15. Clinical Results in Lymphoma II
Authors: A Zelenetz, G Donnelly, N Pandit-Taskar, J Humm, C Divgi, F Morschhauser, D Huglo, G Martinelli, G Paganelli, P Zinzani, D Hadjiyiannakis, A Liberati, T Illidge, N Milpied, J Kalmus, P Morel, U Reimann, R Marcus
Journal: Annals of Oncology (2005)
Salt Intake and Salt Need
Authors: Lewis K. Dahl
Journal: New England Journal of Medicine (1958)

Studies on Patients Subjected to Drastic Salt Restriction while under Continuous ObservationDuring the past ten years, I have personally studied on metabolic wards some 75 adults before and after drastic reduction in sodium intake.23,36,39,68 69 , 70 The majority of these subjects had so-called "essential" hypertension, but I have also studied normal volunteers and persons with unrelated diseases for periods of several weeks to nearly three months after the same degree of salt restriction. No difference in response was noted between the groups with and without hypertension. With 2 exceptions, these patients have had good renal function, and none had had a . . .
Isolation System for General Hospitals
Journal: BMJ (1974)

A four-category isolation system has been used for three years. It is based on the principle that different precautions are needed against different diseases. There are three types of source isolation and one of protective isolation. Coloured door cards indicate the main precautions on the front and the main diseases to which they apply on the back. The system encourages application of effective precautions without waste of effort on those that are irrelevant to some diseases.
Erratum: Global Epidemiology of Pediatric Severe Sepsis: The Sepsis Prevalence, Outcomes, and Therapies Study
Authors: Beverley Sheares
Journal: American Journal of Respiratory and Critical Care Medicine (2016)

Although we did not report it in the article, when we examined pediatric and adult groups separately, there were no differences between the intervention and control groups with regard to the primary outcomes.We had substantially more females than males in our sample because parents, predominantly mothers, were the respondents for the pediatric group.We do not believe that our attrition rate contributed to the finding of no difference between the groups.Although we had several participants who did not complete the study, nearly 80% did.The study was powered to detect a difference even with this degree of loss to follow up.We used intention-to-treat analysis, and there was no difference.We believe that the initiation of subspecialty care, including the asthma teaching that occurred in both groups during their visits and the medical care that was provided, led to a reduction in asthma morbidity in both groups and may have blunted any effects that the written asthma action plan might have had.We agree with Dr. Anand and colleagues' conclusion.Our results confirmed that high-risk populations with poor asthma control may experience sustained and substantial reductions in symptom frequency and emergency care and improvement in asthma quality of life in subspecialty care and that the written asthma action plan may not be needed.
FRANCE
Journal: JAMA (1960)

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Radioactive Microspheres
Authors: Gerd Wunderlich
Journal: Clinical Nuclear Medicine (2020)

Microspheres for radioembolisation of liver malignancies can be labelled with different radionuclides such as 90Y, 166Ho, and 188Re. The characteristics of these labelled microspheres are described. In the last decade, most clinical experiences have been obtained with commercial 90Y microspheres. Another special possibility is the application of 166Ho microspheres in addition to visualisation by magnetic resonance imaging. An alternative for in-house preparations are 188Re particles that can be labelled to clinical demands if a 188Wo/188Re generator is available.
Laryngoscope, St Louis
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Obstetrical Nursing.
Journal: JAMA (1922)

Miss Van Blarcom has prepared one of the most valuable contributions on obstetric nursing that have been published in late years. In many ways it reflects the influence of the chief under whom she served at Johns Hopkins. The lucid diction, the human touch manifested in many places, and the completeness of exposition of the subject make the book not only for the nurse, as avowedly intended, but also for the physician and all those who are associated with him in the care of the mother during the expectant period, and later when her hopes have been realized. The merits of the introduction, the chapters on prenatal care and on the mental hygiene of the expectant mother, and those chapters devoted to the care of the mother and her child in sickness and in health stand out preeminently as the fruits of a wide experience, a clarity of vision, and
A Correction
Journal: BMJ (1908)

Make Into a paste with cold water, and apply to the part for ten to fifteen minutes, then wash off.(2) The time varies according to strength and growth of the hair.(3) There is no objection except that it must be repeated at Intervals.Barium sulphide ras no permanent effect as a depilatory.Electrolysis gives good results in some cases, rot in all.AVIAN PROTEOSOMA AND MALARIA.SEARCHER.-Thesaymptoms of avian malaria resemble those seen In the human subject.The bird after an incubation period, in whtch the parasites are multiplying, gets fever, Ift is ill, feathers ruffled, and mopish.It the infecsion is severe it may die, or it less so recovery may take place.Relapses are common, but eventually 'the infection dies out of its own accord.This is similar to human malaria.'Pathologically the Ilver and spleen are enXlarged, congested, and black pig- ment (melanin) is foulnd in them.Those facts, together with the classificatfon of the parasites and their life-history, 'described in tne JOVRNAL of January 11th, are sufflcient to showthat proteosoma is a disease the equivalentof malaria in man.MEDICAL PRACTICE IN ONTARIO.G. R. H.-(1) The G(neral Medica Counlcil of the Province of Ontario is the College of Physicians ILnd Surgeons of Ontario.
Specialty Abstracts
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
GASTROINTESTINAL PERFORATIONS AND THEIR DIAGNOSIS.
Authors: F. GREGORY CONNELL
Journal: JAMA (1903)

<h3>INTRODUCTION.</h3> That the most urgent need of the surgeon, when called to a gunshot wound of the abdomen, at the end of the nineteenth century, should be exactly similar to that of the surgeon under the same circumstances during the closing days of the eighteenth century is truly a remarkable circumstance. This painful lack of ingenuity or resourcefulness is a sad commentary on the century, which in many respects has been so brilliant from a surgical point of view. In support of the accuracy of the above statement, a glance at what might be called ancient history will reveal an instance in which exactly similar circumstances gave rise to exactly the same line of thought with the employment of almost the same methods and materials in an effort to arrive at an early diagnosis in a case of suspected or possible perforation of the gut. In "Hunter on the
Allergic Rhinitis in an Allergy Clinic Nurse
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Corrigan sign
Authors: R. A. Dickey
Journal: JAMA (1969)

<h3>To the Editor:—</h3> In sympathy with the current effort to change the face of everything, the major conglomerate corporations change their names as more and more companies are agglutinated to them. Thus, Insilco and CPC International will be joined soon by Union Tank Car under a new flag. Who would guess that "CPC" was inspired by corn syrup? Obviously medicine needs to disguise its blessings. For the postfractural hypostatic pneumonia, I suggest<i>Fraxpo</i>. For diabetes, arteriosclerotic lower extremities problems, and urinary infections, let us have<i>Glurosicco</i>. The fellow who is having his blood vessels embolized, deembolized, catheterized, pressurized, tied, replaced, or rebuilt suffers from<i>Vasculack</i>. Anyone who receives more than 15 units of blood per surgical session has been the victim of<i>Sangblast</i>. My enlightenment followed a recent episode: Jones(a patient): Morning, Doctor. Came in for my<i>Sixlobelt</i>. Liddle: I beg your pardon, Mr. Jones, did you say "sixlobelt?"
POLICIES ADOPTED BY THE HOUSE OF DELEGATES
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Interaction between Smoking and Asbestos in Human Lung Adenocarcinoma: Role of K-ras Mutations
Authors: Harri Vainio, Kirsti Husgafvel-Pursiainen, Sisko Anttila, Antti Karjalainen, Peter Hackman, Timo Partanen
Journal: Environmental Health Perspectives (1993)

To investigate the role of tobacco smoking and asbestos fibers in the etiology of human lung cancer, we examined the activating point mutations in the K-ras oncogene in DNA samples from 49 patients.Mutations were found more often in tissue from adenocarcinomas (12/21) than in tissue from tumors other than nonadenocarcinomas of the lung (3/28).Among the adenocarcinoma patients, asbestos exposure was predic- tive of K-ras mutation (odds ratio, 4.9; 95% confidence interval, 0.7-34.3); in patients with other types of lung cancer, the relation appeared to be an inverse one, but the numbers were small.The proportion of heavy smokers (over 50 pack-years) was 60% among people with K-ras mutations and 35% among the K-ras-negative subjects, suggesting that smoking causes K-ras mutations.If mutations in K-ras genes are caused by smoking, asbestos would act as a promoting agent by conferring selective growth conditions for clonal expansion on these mutated cells.Asbestos may favor recruitment of (initiated) K-ras mutation-positive cells in the multistage process of carcinogenesis by stimulating cellular growth.
Multiple myeloma and human immunodeficiency virus‐1 (HIV‐1) infection
Authors: T.T. Yee, K. Murphy, M. Johnson, S.H. Abdalla, G.S. Patton, C.A. Lee, A.B. Mehta
Journal: American Journal of Hematology (2001)

Multiple myeloma (MM) in three human immunodeficiency virus (HIV)-infected patients is reported. HIV infection predisposes to the development of high-grade B-cell lymphomas, but few cases of plasma cell tumours in association with HIV have been reported. The coincidence of HIV infection and neoplasia highlights the distinct roles of immunodeficiency and infection with herpesviridae, including HIV itself, in the pathogenesis of HIV-related tumours. In addition, a number of cytokines (e.g., interleukin-6 [IL-6]) and angiogenic factors (e.g., vascular endothelial growth factor [VEGF] and basic fibroblastic growth factor [bFGF]) may play a role in the initiation, maintenance, and progression of multiple myeloma (MM). Infection was the first clinical consideration to the cause of the illness in two of our HIV-seropositive patients. The diagnosis of MM may be difficult in patients with advanced HIV infection as they often have renal failure, bone marrow plasmacytosis, repeated infections, and polyclonal hypergammaglobulinaemia, due to HIV infection itself, opportunistic pathogens, and/or medication. Am. J. Hematol. 66:123–125, 2001. © 2001 Wiley-Liss, Inc.
Fixed eruption caused by ciprofloxacin with cross‐sensitivity to norfloxacin
Authors: M. D. Alonso, J. A. Martín, S. Quirce, I. Dávila, A. Lezaun, M. Sanchez Cano
Journal: Allergy (1993)

A case of fixed eruption caused by ciprofloxacin is reported. To our knowledge, no other cases have been published. Cross‐sensitivity with another fluoroquinolonc has been demonstrated.