tbuckley/cabot-search huggingface dataset:
Naproxen and agranulocytosis
Authors: N. Nygard
Journal: JAMA (1987)

<h3>To the Editor.—</h3> Agranulocytosis has been reported as a rare complication of nonsteroidal anti-inflammatory drug therapy. Specific nonsteroidals that have been reported to cause this include phenylbutazone,<sup>1</sup>indomethacin,<sup>2</sup>fenoprofen,<sup>3</sup>benoxaprofen,<sup>4</sup>ibuprofen,<sup>5</sup>and tolmetin.<sup>5</sup>A case of agranulocytosis during naproxen therapy that resolved when administration of the drug was discontinued is reported herein. Evidence from a search for the mechanism of the neutropenia is also presented. <h3>Report of a Case.—</h3> An 87-year-old man with long-standing seropositive rheumatoid arthritis was admitted for elective hernia repair. His arthritis had been managed in the four years prior to admission with naproxen, 250 mg twice a day. On admission he was noted to have a white blood cell count of 0.0023 ×10<sup>3</sup>/mm<sup>3</sup>(0.0023 ×10<sup>9</sup>/L), with 16% (0.16) polymorphonuclear leukocytes (0.000368 × 10<sup>3</sup>/mm<sup>3</sup>[0.000368 × 10<sup>9</sup>/L]) and 0% (0.00) band forms.
Review: Antioxidant supplements do not reduce all-cause mortality in primary and secondary prevention
Authors: Gary A. Green
Journal: Annals of Internal Medicine (2008)

Source Citation Bjelakovic G, Nikolova D, Gluud L, Simonetti R, Gluud C. Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases. Cochrane Database Syst Rev. 2008;(2):CD007176. 18425980
It takes four years.... Reversing the acceleration trend
Authors: W. R. Hejna
Journal: JAMA (1975)

MEDICAL school curricula have undergone significant methodological changes during the past ten years, prompted by such factors as social demand, technological development, and fiscal pressure. Among those changes is a trend toward shortening the time from high-school graduation to starting practice; this is most usually accomplished by accelerating the rate at which students are expected to learn the medical school portion of that continuum. About 50 schools have regular or optional three-year curricula. Some have an accelerated premedical/ medical school program of six years. Rush Medical College of Chicago recently reversed this trend by changing its regular three-year program to the more standard four-year format. The reasoning behind this move deserves comment. Further, the intensely dynamic sociopolitical climate in which medical education exists during the current decade justifies repeated review of the validity for moving in the direction of a shortened curriculum. Rush Medical College was chartered in 1837 and
ORIGINAL INVESTIGATIONS ON THE NATURAL HISTORY, (SYMPTOMS AND PATHOLOGY) OF YELLOW FEVER. 1854-1894.
Authors: JOSEPH JONES
Journal: JAMA (1895)

<h3>Chapter III.</h3> None of the tables in the article of Dr. Faget support the assertion in the article, "Fevers," of the new French Dictionary of Medicine (1871): "In some fevers the remission is long and complete, as in yellow fever, for instance, in which the<i>initial attack</i>is separated from the<i>terminal fever</i>by a<i>remission</i>of one or several days duration." (Vol. XIV., p. 742.) On the contrary, according to Dr. Faget, "yellow fever shows<i>one single effervescence</i>—only<i>one paroxysm</i>, never a true remission, and the unique attack subsides immediately. Its progress is regressive as soon as it appears. This last peculiar feature would not show as plainly in our tables, but for the fact that they often begin after the second and even third day. The fact is that the decline is marked from the very beginning, in the line of the fever only; as for the
Manuscripts Approved for JNCI, November 1 to December 1, 1967
Journal: JNCI Journal of the National Cancer Institute (1968)

Journal Article Manuscripts Approved for JNCI, November 1 to December 1, 1967 Get access JNCI: Journal of the National Cancer Institute, Volume 40, Issue 1, January 1968, Page 193, https://doi.org/10.1093/jnci/40.1.193 Published: 01 January 1968
Small-Bowel Endoscopy
Authors: J. D. Waye
Journal: Endoscopy (1999)

Endoscopic mucosal resection (EMR) has gained increasing popularity in the treatment of esophageal and gastric mucosal cancers in Japan, for complete local resection of the cancer-bearing mucosa. In Western countries, the concept of mucosal cancer and the necessity of treating it are gradually but steadily coming to be accepted. As a treatment for inoperable cases of advanced cancer, on the other hand, intubation with self-expanding metal stents has been widely accepted as a less invasive form of palliation for malignant obstruction of the upper gastrointestinal tract. Tumor ingrowth into the stent can be mechanically avoided by adding a membrane coating to it. In the last two years, applications for therapeutic endoscopy in the treatment of esophageal and gastric tumors have continued to widen.
Rethinking Adherence
Authors: John F. Steiner
Journal: Annals of Internal Medicine (2012)

In 2012, the Centers for Medicare & Medicaid Services (CMS) will introduce measures of adherence to oral hypoglycemic, antihypertensive, and cholesterol-lowering drugs into its Medicare Advantage quality program. To meet these quality goals, delivery systems will need to develop and disseminate strategies to improve adherence. The design of adherence interventions has too often been guided by the mistaken assumptions that adherence is a single behavior that can be predicted from readily available patient characteristics and that individual clinicians alone can improve adherence at the population level. Effective interventions require recognition that adherence is a set of interacting behaviors influenced by individual, social, and environmental forces; adherence interventions must be broadly based, rather than targeted to specific population subgroups; and counseling with a trusted clinician needs to be complemented by outreach interventions and removal of structural and organizational barriers. To achieve the adherence goals set by CMS, front-line clinicians, interdisciplinary teams, organizational leaders, and policymakers will need to coordinate efforts in ways that exemplify the underlying principles of health care reform.
Comments and Critiques on the EMBRACE Health Care Reform Plan
Authors: Gilead I. Lancaster, Ryan O'Connell, David L. Katz
Journal: Annals of Internal Medicine (2009)

Letters3 November 2009Comments and Critiques on the EMBRACE Health Care Reform PlanGilead I. Lancaster, MD, Ryan O'Connell, MD, and David L. Katz, MD, MPHGilead I. Lancaster, MDFrom Bridgeport Hospital and Yale University School of Medicine, New Haven, CT 06519, and Yale Prevention Research Center, Derby, CT 06418.Search for more papers by this author, Ryan O'Connell, MDFrom Bridgeport Hospital and Yale University School of Medicine, New Haven, CT 06519, and Yale Prevention Research Center, Derby, CT 06418.Search for more papers by this author, and David L. Katz, MD, MPHFrom Bridgeport Hospital and Yale University School of Medicine, New Haven, CT 06519, and Yale Prevention Research Center, Derby, CT 06418.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-151-9-200911030-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:The Expanding Medical and Behavioral Resources with Access to Care for Everyone (EMBRACE) plan was developed as a blend of what is needed and what is feasible in health care reform, but because of space constraints, many details of the plan were omitted. For more details, readers can visit www.hpfhr.org.EMBRACE is not based on opposition to single-payer proposals; rather, it shares the goals of a single-payer system but seeks to achieve those goals in a form more likely to be tenable in the context of U.S. politics and values and that might even offer operational advantages. The ... Author, Article, and Disclosure InformationAuthors: Gilead I. Lancaster, MD; Ryan O'Connell, MD; David L. Katz, MD, MPHAffiliations: From Bridgeport Hospital and Yale University School of Medicine, New Haven, CT 06519, and Yale Prevention Research Center, Derby, CT 06418.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe Expanding Medical and Behavioral Resources with Access to Care for Everyone Health Plan Gilead I Lancaster , Ryan O'Connell , David L. Katz , JoAnn E. Manson , William R. Hutchison , Charles Landau , Kimberly A. Yonkers , and Comments and Critiques on the EMBRACE Health Care Reform Plan Quentin D. Young Comments and Critiques on the EMBRACE Health Care Reform Plan Richard L. O'Brien and Donald Frey Comments and Critiques on the EMBRACE Health Care Reform Plan Christopher K. Johnson Comments and Critiques on the EMBRACE Health Care Reform Plan Gary R. Gibson Metrics 3 November 2009Volume 151, Issue 9Page: 672-673KeywordsConflicts of interestElderlyHealth careHealth information technologyHealth insuranceLong-term careMedical ethicsPopulation statistics ePublished: 3 November 2009 Issue Published: 3 November 2009 Copyright & PermissionsCopyright © 2009 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Medical Consultation: Role of the Internist on Surgical, Obstetric and Psychiatric Services.
Journal: Annals of Internal Medicine (1991)

The Literature of Medicine1 May 1991Medical Consultation: Role of the Internist on Surgical, Obstetric and Psychiatric Services.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-114-9-819_8 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail AbstractAbstractThis new edition provides authoritative coverage of assessment and care of pre- and post-operative medical problems. Features include the latest advances in cardiology, including new information on reduction of surgical risk, dipyridamole-thallium scanning, invasive monitoring with Swan-Ganz catheters, and the most current data on the Goldman Cardiac Risk Index. This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1991Volume 114, Issue 9Page: 819-819KeywordsCatheters ePublished: 1 December 2008 Issue Published: 1 May 1991 PDF downloadLoading ...
Scintigraphy in traumatic lesions of liver and spleen
Authors: G. W. Evans
Journal: JAMA (1972)

Simultaneous splenic and hepatic scintigrams were performed with technetium Tc 99m colloid on 19 patients who had sustained abdominal trauma. Five cases of splenic hematoma were diagnosed; all were confirmed and successfully treated. Three cases of liver hematoma were diagnosed; two were confirmed, and all were successfully managed. There is no evidence that the procedure failed to detect clinically significant lesions of the liver or the spleen.
Case-Control Cancer Mortality Study and Chlorination of Drinking Water in Louisiana
Authors: Marise S. Gottlieb, Jean K. Carr
Journal: Environmental Health Perspectives (1982)

Several Louisiana parishes (counties) using the Mississippi River for their source of public drinking water have the highest mortality rates (1950-69) in the United States for several cancers. Therefore, a case-control mortality study on cancer of the liver, brain, pancreas, bladder, kidney, prostate, rectum, colon, esophagus, stomach, non-Hodgkin's lymphoma, multiple myeloma, leukemia, Hodgkin's disease, lung; breast and malignant melanoma, from 1960 to 1975 in South Louisiana parishes grouped for similarities in industrial characteristics, having approximately equal exposure of the population to surface and groundwater, was conducted. Noncancer deaths were randomly selected as controls and matched to the case death on age, race, sex, and year and parish group of death. Water source at death was assigned based on the residence at death and described as surface or ground and chlorinated or nonchlorinated. A significantly increased risk for surface, chlorinated water use was noted for rectal cancer. No risk could be demonstrated for colon cancer. The risk noted for bladder cancer by other investigators is not substantiated. Brain cancer risk appears to be associated with chlorinated groundwater, but this may be industrial confounding. Breast cancer demonstrated a slight, but significant, risk associated with surface chlorinated water. This risk, however, might be due to confounding of rural life style, early childbearing and large families with nonchlorinated water found in these settings. Chlorination risk for kidney cancer was not significant. No risk was observed in association with surface water for other cancers of the gastrointestinal or urinary tract. Multiple myeloma was significantly associated with a risk from ground water.
Physical medicine and rehabilitation
Authors: H. H. Stonnington
Journal: JAMA (1979)

Frank Krusen established the first Department of Physical Medicine in Philadelphia in 1929. He and other pioneers, such as Miland Knapp, Howard Rusk, and Earl Elkins, created a specialty that emphasized rehabilitation of chronically disabled patients rather than treatment of disease as such.<sup>1,2</sup>Early neglect of disabling injuries and illnesses is far more costly both in money and in misery than an early aggressive program of rehabilitation designed to restore the person to the highest level of physical, economic, social, and emotional self-sufficiency.<sup>3</sup> Physical medicine and rehabilitation is in part a service specialty that helps physicians in other specialties to design patient programs that will relieve pain and contractures and improve strength, as well as to design prostheses, orthoses, ambulation aids, and adaptive equipment and programs for bowel, bladder, and skin care. It is also a primary care specialty for persons with chronic catastrophic disabilities. The specialist in
Non uniform atherosclerotic plaque distribution near the septal perforator: Intravascular ultrasound evidence for the importance of rheological factors in atheroma development Mohammed A. Balghith, Mandish S. Rai, Atila lyisoy, E. Murat Tuzcu, Steven E. Nissen. The Cleveland Clinic Foundation, Cleveland, OH
Journal: Journal of the American College of Cardiology (2001)
Invited response
Authors: C. E MURRY, R. B JENNINGS, K. A REIMER
Journal: Cardiovascular Research (1993)

Journal Article Invited response Get access CHARLES E MURRY, CHARLES E MURRY Department of Pathology University of Washington Seattle WA. USA Search for other works by this author on: Oxford Academic PubMed Google Scholar ROBERT B JENNINGS, ROBERT B JENNINGS Department of Pathology University of Washington Seattle WA. USA Search for other works by this author on: Oxford Academic PubMed Google Scholar KEITH A REIMER KEITH A REIMER Department of Pathology University of Washington Seattle WA. USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 27, Issue 4, April 1993, Pages 688–689, https://doi.org/10.1093/cvr/27.4.688b Published: 01 April 1993
The Plague
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Early confirmation of stress fractures in joggers
Authors: J. F. Norfray
Journal: JAMA (1980)

Four joggers had early confirmation of clinically suspected stress fractures by radionuclide bone scans. The radioactive bone scan was abnormal as early as six weeks prior to the appearance of conventional roentgenographic changes. The stress fractures involved the bones of the lower extremities and included the femur, tibia, and calcaneus. Radioactive bone scanning also correctly identified stress fractures with bilateral involvement and referred pain. In joggers, when a stress fracture is clinically suspected and the conventional radiographs are negative, a radioactive bone scan is indicated for early confirmation and institution of appropriate treatment. (<i>JAMA</i>243:1647-1649, 1980)
Microsporum Gypseum Infections in Cucumber Growers
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Psychiatry
Authors: D. X. Freedman
Journal: JAMA (1992)

Observations of the past decade on one of the anxiety disorders, obsessive compulsive disorder (OCD), are instructive in terms of the unanticipated findings. These findings demonstrate how discoveries like those in the area of 5-hydroxytryptamine (5-HT) pharmacology modify concepts of both drugs and illness. As a plethora of new therapeutic agents arrive, this experience may help to prepare the clinician for future conceptual and pragmatic shifts. New findings in OCD include how unexpectedly common this disorder is, its presentation to medical practitioners, its biologic characteristics, and its "tilt" to requiring 5-HT specificity for treatment. Modern epidemiology<sup>1</sup>suggests that this psychiatric disorder, which once was considered rare (one in 10000 persons), is actually common (approximately one in 40 persons-more common than asthma or diabetes). The previous underestimates are related to an older diagnostically nonspecific epidemiology, often inefficient therapy, and reluctance of patients to make themselves evident because of stigma. Patients
AMA/Glaxo Wellcome Achievement Award Winners
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
In Vitro Dynamic Solubility Test: Influence of Various Parameters
Authors: Sylvie Thelohan, Alain de Meringo
Journal: Environmental Health Perspectives (1994)

This article discusses the dissolution of mineral fibers in simulated physiological fluids (SPF), and the parameters that affect the solubility measure- ment in a dynamic test where an SPF runs through a cell containing fibers (Scholze and Conradt test).Solutions simulate either the extracellular fluid (pH 7.6) or the intracellular fluid (pH 4.5).The fibers have various chemical compositions and are either continuously drawn or processed as wool.The fiber solubility is determined by the amount of SiO2 (and occasionally other ions) released in the solution.Results are stated as percentage of the initial silica content released or as dissolution rate v in nm/day.The reproducibility of the test is higher with the less soluble fibers (10% solubility), than with highly soluble fibers (20% solubility).The influence of test parameters, including SPF, test duration, and surface area/volume (SA/V), has been studied.The pH and the inorganic buffer salts have a major influence: industrial glasswool composition is soluble at pH 7.6 but not at pH 4.5.The opposite is true for rock-(basalt) wool composition.For slightly soluble fibers, the dissolution rate v remains constant with time, whereas for highly soluble fibers, the dissolution rate decreases rapidly.The dissolution rates believed to occur are vl, initial dissolution rate, and v2, dissolu- tion rate of the residual fibers.The SA of fibers varies with the mass of the fibers tested, or with the fiber diameter at equal mass.Volume, V, is the chosen flow rate.An increase in the SA/V ratio leads to a decrease in the dissolution rate.Test conditions corresponding to high values of SA/V may lead to saturation of the species released in the solution, slowing the dissolution process.The in vitro solubility test described here is used to investi- gate the dissolution rate of mineral fibers of various chemical compositions.The test parameters must be clearly defined since they have a major effect on the dissolution rate measured.Experimental conditions must be chosen so that the dissolution rate measured in vitro is in good agree- ment with in vivo experiments.-
Swiss study suggests condom use not necessary for some HIV-positive patients
Authors: None Eurosurveillance editorial team
Journal: Eurosurveillance (2008)

The United Nations Joint Programme on HIV/AIDS (UNAIDS) and the World Health Organization (WHO) issued a joint statement on 1 February regarding the use of condoms as a measure of protection against the AIDS virus [1]. The statement followed an article by Switzerlands Federal AIDS Commission, which reviewed a large body of literature to conclude that certain HIV-positive people may be able to have sexual intercourse with their seronegative partners without risk of transmitting the virus.