tbuckley/cabot-search huggingface dataset:
RADIOLOGY
Authors: T. Kelly, M. Prah, S. Jogal, M. Maheshwari, S. Lew, K. Schmainda, G. Kannan, S. Khatua, W. Zaky, L. Ketonen, M. Drogosiewicz, B. Dembowska-Baginska, E. Jurkiewicz, K. Nowak, D. Perek, D. Hirpara, M. Bhatt, K. Scheinemann, Y. Shimizu, A. Kondo, M. Miyajima, H. Arai, R. Dvir, S. Shiran, L. B.- Sira, J. Roth, U. Tabori, E. Bouffet, C. Durno, M. Aronson, S. Constantini, R. Elhasid, J. Fangusaro, J. Marsh, C. Bregman, A. Diaz, R. Byrne, E. Ziel, S. Goldman, R. Calmon, D. Grevent, T. Blauwblomme, S. Puget, C. Sainte-Rose, P. Varlet, C. Dufour, J. Grill, A. Saitovich, M. Zilbovicius, F. Brunelle, N. Boddaert, L. Wei, A. M. Tan, P. H. Tang, E. Orphanidou-Vlachou, N. Vlachos, N. Davies, T. Arvanitis, R. Grundy, A. Peet, S. Withey, J. Novak, L. MacPherson, A. Peet, S. Avula, R. Kumar, B. Pizer, B. Pettorini, D. Garlick, C. Mallucci, W. Reddick, J. Guo, J. Glass, J. Pryweller, A. Gajjar, S. Thust, E. Blanco, K. Mankad, A. Michalski
Journal: Neuro-Oncology (2014)
PROGRESS OF PHYSICIANS' REMUNERATION.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hyperglycaemia and mortality
Authors: K. Asadollahi, N. Beeching, G. Gill
Journal: Journal of the Royal Society of Medicine (2007)

Several studies over the last decade have linked hyperglycaemia on hospital admission with subsequent mortality risk. The evidence is strongest for patients with myocardial infarction or acute coronary syndromes, but evidence also links hyperglycaemia with mortality from stroke and other medical illnesses. The effect seems independent of a previous diagnosis of diabetes mellitus; indeed, some studies suggest that mortality may be higher in patients with hyperglycaemia and no previous diabetes diagnosis compared with known diabetic patients. The effect on outcome of therapeutically lowering blood glucose levels has been considered in a small number of studies, but so far the results are conflicting. Further work is needed, focusing on more standardized surveys—previous studies vary in their use of blood or plasma, as well as cut-off levels for hyperglycaemia—and larger intervention studies.
Congenital mesoblastic nephroma and polyhydramnios
Authors: E. Blank
Journal: JAMA (1978)

Polyhydramnios and premature delivery complicated the pregnancies of three women whose infants were born with renal tumors. In each case the tumor was a mesoblastic nephroma. The liquid of polyhydramnios enhances detection of masses in the fetal abdomen by ultrasound. In the future, mesoblastic nephroma may, therefore, be diagnosed antenatally. Tumors in these infants, which have proved in most cases to be benign, are usually cured by surgical removal. Occasionally, local infiltration and adhesions prevent removal. The fate of the infant with residual tumor is not known. (<i>JAMA</i>240:1504-1505, 1978)
Diabetes Mellitus
Authors: Elliott P. Joslin
Journal: New England Journal of Medicine (1947)

THE most notable achievement in diabetes mellitus during 1946 I consider to be the demonstration by Lukens and Dohan,1 of the Cox Metabolic Unit, University of Philadelphia, of a fourth method by which the disease can be caused experimentally in animals. They accomplished this by the production of hyperglycemia in a cat for a period of two weeks. It will be remembered that Haist, Campbell and Best2 showed that by the simultaneous administration of insulin, diabetes can be prevented in a dog receiving injections of anterior pituitary extract and that Lukens and Dohan3 , 4 prevented and "cured" the diabetes in a . . .
The Challenge Posed by Endocrine-Disrupting Chemicals
Authors: John Ashby, Erik Houthoff, Sandy J. Kennedy, Jim Stevens, Remi Bars, Friedrich W. Jekat, Pamela Campbell, Jim Van Miller, Francis M. Carpanini, Geoffrey L. P. Randall
Journal: Environmental Health Perspectives (1997)

Rapid regulatory developments in the area of environmental endocrine disruption present a series of potential problems that are identified and illustrated with examples taken from the recent literature. A list of priorities is provided, including the need for additional epidemiological and wildlife studies, the derivation of a coordinated testing strategy, agreement on the toxicities expected of endocrine disrupting agents, and acceptance that whole animal assays will be uniquely critical in this area of toxicology. The intrinsic difficulty of attempting to simultaneously study all aspects of endocrine disruption indicates the need to reduce the scope of the problem, which can be achieved by first studying toxicities mediated by sex hormone receptors.
Unusual T-Wave Abnormality
Authors: Herman H. Ricketts
Journal: JAMA (1969)

An unusual electrical alternans of the T wave occurred in which there were alternating positive and negative T waves with consecutive complexes. The clinical significance of this phenomenon in a patient with acute alcoholism, organic heart disease, and low serum magnesium level could not be accurately assessed. There was no evidence of paradoxical pulse or pulsus alternans, and the electrocardiogram finding spontaneously reverted.
Pancreatic Abscesses
Authors: Andrew L. Warshaw
Journal: New England Journal of Medicine (1972)

PANCREATIC abscesses are collections of pus and devitalized tissue within the pancreas or extending out from it. Untreated, they give rise to severe and often dramatic complications and are almost uniformly fatal.1 2 3 4 5 6 In contrast to pseudocysts of the pancreas, which contain sterile pancreatic secretions and debris, pancreatic abscesses are bona-fide infections, with bacteria recovered in over 90 per cent of cases.1 2 3 4 5 6 Clinical PictureAlthough some patients have a pancreatic abscess during the first manifestations of illness, most abscesses occur as a complication of pancreatitis having the usual distribution of antecedents: alcoholism and gallstones predominate, with most of the rest due . . .
Tularemia
Authors: Edward Francis
Journal: JAMA (1983)

Tularemia occurs in nature as a very fatal bacteremia of various rodents (especially rabbits) and is due to<i>Bacterium tularense</i>; it is transmissible to man as an accidental infection by the bite of an infected bloodsucking insect or tick, or by the lodgment on his hands of the blood or internal organs of an infected rodent, as in the case of market men, cooks, hunters or laboratory workers. Among the few diseases of man that have been discovered in the last fifteen years is tularemia. It is the only disease of man that has been elucidated from beginning to end by American investigators alone. These investigators have worked in widely separated states, and in most instances each made his first contribution while in ignorance of the work of the others. The first observations of each were characterized by the nature of the work for which he was especially trained; thus,
Subcutaneous sumatriptan in acute migraine
Journal: JAMA (1991)

<h3>In Reply.</h3> —Dr Korenfeld raises the question of whether visual disturbances associated with subcutaneous sumatriptan could have resulted from relative ischemia secondary to posterior ciliary artery or central renal artery vasoconstriction. When we reviewed the patients who were experiencing visual difficulties, we noted that seven of the 734 sumatriptan-treated patients had true visual disturbances. These complaints generally began minutes after the subcutaneous injection of sumatriptan and resolved within several minutes to 1 hour. In only a single patient who received a second dose of sumatriptan was the visual disturbance duplicated by the second injection. No long-term visual complaints were noted except in a single patient who had blurred vision in one eye, which began several hours after the sumatriptan injection, and a subsequent ophthalmologic evaluation concluded that this problem was secondary to her severe myopia and not to sumatriptan. Whether the posterior ciliary artery or the central retinal artery has
Studies on the microsomal metabolism and binding of polybrominated biphenyls (PBBs).
Authors: G A Dannan, R W Moore, S D Aust
Journal: Environmental Health Perspectives (1978)

The metabolism of polybrominated biphenyls (PBBs) was studied in vitro by using rat liver microsomes in the presence of NADPH and atmospheric O2. Quantitative recoveries of all PBBs were obtained after incubations with control or 3-methylcholanthrene (MC) induced microsomes. Of the twelve major components, losses of only peaks 1 (2,4,5,2',5'-pentabromobiphenyl) and 3 (a hexabromobiphenyl) were observed following incubations with microsomes from phenobarbital (PB)- or PBBS- pretreated rats. Of seven structurally identified PBB components, only peak 1 has a bromine-free para position. Peaks 1, 2, and 5 all have two adjacent unsubstituted carbons, yet only peak 1 is metabolized. Of two dibromobiphenyl model compounds studied, the 2,2'-congener was very rapidly metabolized by PB-induced microsomes whereas its 4,4'-isomer was not. These results suggest that the presence of a free para position is required for the metabolism of brominated biphenyls. Of lesser importance appears to be the number of bromines or the availability of two adjacent unsubstituted carbons. In vivo evidence for the metabolism of peaks 1 and 3 was also provided by their drastically diminished levels in liver and milk extracts. When a 14C-PBB mixture consisting almost exclusively of peaks 4 (2,4,5,2',4',5'-hexabromobiphenyl) and 8 (2,3,4,5,2',4',5'-heptabromobiphenyl) was incubated with PB- or PBBs- induced microsomes and NADPH, only traces of radioactivity remained with the microsomes after extensive extraction. However, less radioactivity was bound to microsomes from MC pretreated or especially control rats. No radioactivity was bound to exogenous DNA included in similar microsomal incubations, regardless of the type of microsomes used. Under the same conditions, [3H]-benzo[a]pyrene metabolites were bound to DNA, and PBB-induced microsomes enhanced this binding more than six-fold.
Software
Authors: Peter L. Elkin
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Uric Acid Metabolism in Normal Man and in Primary Gout
Authors: Alexander B. Gutman, Ts'ai-Fan Yü
Journal: New England Journal of Medicine (1965)

THE metabolism of uric acid in man, with special reference to its presumptive aberrations in gout, has been the subject of several excellent reviews in recent years, notably those of Seegmiller et al.,1 Sorensen,2 Talbott3 and Wyngaarden.4 The purpose of the present survey is to integrate into this body of knowledge a few fresh bits of information and also to offer certain reinterpretations of the data.Chemical and Biologic Characterization of Uric AeroUric acid (2,6,8-trioxypurine) owes its weakly acidic properties to ionization at N-9 (Fig. 1) in the physiologic pH range.5 The pKa of uric acid is 5.75, according . . .
THE THYMUS GLAND
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Immunotherapy for metastatic cancer. Establishing a 'proof of principle'
Authors: S. Hellman
Journal: JAMA (1994)

Often in medical investigation there is a period of early enthusiasm when the initial discovery is appreciated and the possible applications and implications are considered. When the discovery is a new therapeutic modality, this initial period of great expectation is followed by a greater understanding of both the toxicity of the agent as well as the limitations of the treatment efficacy, leading to some disillusionment. It is only with time, experience, and careful reporting of the complete experience that the new therapy can be evaluated and its importance determined. This has surely been the case with interleukin 2 (IL-2) treatment for cancer. Early reports of the use of IL-2 published by the National Cancer Institute surgery group led by Dr Rosenberg<sup>1,2</sup>generated considerable interest. Much was written in both the medical literature and the lay press following publication of some of the initial responses observed with IL-2 treatment for
A PUTATIVE PLACEBO ANALYSIS OF THE EFFECTS OF SACUBITRIL/VALSARTAN IN HEART FAILURE ACROSS THE FULL RANGE OF EJECTION FRACTION
Authors: Muthiah Vaduganathan, Brian Claggett, Milton Packer, Jiri Widimský, Petar Seferovic, Adel Rizkala, Martin Lefkowitz, Victor Shi, John McMurray, Scott D. Solomon
Journal: Journal of the American College of Cardiology (2020)
PENTAMIDINE NONTOXICITY
Authors: KARL A. WESTERN
Journal: Annals of Internal Medicine (1969)

Letters and Comments1 January 1969PENTAMIDINE NONTOXICITYKARL A. WESTERN, M.D., MYRON G. SCHULTZ, D.V.M., M.D., D.C.M.T.KARL A. WESTERN, M.D.Search for more papers by this author, MYRON G. SCHULTZ, D.V.M., M.D., D.C.M.T.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-70-1-234_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:A recent letter in this column by Drs. Emmer and DeVita (1) reports the onset of reversible kidney damage in a 50-year-old woman who was receiving pentamidine isethionate for biopsy-provedPneumocystis cariniipneumonia. The correspondents warn that renal toxicity should be carefully watched for in patients given this drug. We support this warning, but at the same time we hope that it will not be overinterpreted, for we do not believe that renal toxicity is a life-threatening or a major limiting factor in the use of pentamidine. Pentamidine is usually given for life-threatening diseases, and the reported...References1. EMMERDEVITA MVT: Pneumocystis carinii pneumonia and pentamidine isethionate toxicity. Ann. Intern. Med. 69: 637, 1968. LinkGoogle Scholar2. PAYETSANKALE MM: Transitory hyperazotemia during the treatment of human African trypanosomiasis by diamidines. Bull. Soc. Path. Exot. 53: 690, 1960. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited BySynthesis and antiprotozoal activities of benzyl phenyl ether diamidine derivativesSynthesis and Antiprotozoal Activity of Dicationic m -Terphenyl and 1,3-Dipyridylbenzene DerivativesBibliographyThe LeishmaniasesPneumocystis Carinii Pneumonia: Percutaneous Lung Biopsy and Review of Literature 1 January 1969Volume 70, Issue 1Page: 234-235KeywordsAdverse reactionsKidneysPneumocystis carinii pneumoniaToxicity Issue Published: 1 January 1969 PDF DownloadLoading ...
Books Received
Journal: JAMA (1910)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A STUDY OF THE SPINAL FLUID IN FIFTY-TWO CASES OF CONGENITAL SYPHILIS
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 5237: Development of a gene expression database of renal cell carcinoma cases by NGS-combined HiCEP to identify tumor markers
Authors: Makoto Kawaguchi, Hirotaka Matsuo, Ryoko Araki, Seiko Shimizu, Mikiya Takao, Akiyoshi Nakayama, Yosuke Kitamura, Masumi Abe, Keiichi Ito, Nariyoshi Shinomiya
Journal: Cancer Research (2019)

Abstract Objectives: High coverage expression profiling (HiCEP) is an AFLP-based comprehensive gene expression analysis technique invented in Japan. HiCEP has two unique characteristics. First, it can detect low amounts of mRNA with high sensitivity and reliability. Second, HiCEP enables highly quantitative and reproducible mRNA expression analyses. However, it requires complicated processes, including TA cloning of isolated transcripts, to obtain sequence information on detected peaks. We performed next-generation sequencing (NGS)-combined HiCEP and tried to establish a gene expression database of renal cell carcinoma (RCC) cases to identify effective tumor markers. Materials and methods: We collected cancerous and macroscopically non-cancerous regions from 83 RCC cases. Of these, six cases with clear cell RCC were analyzed by HiCEP. Total RNA was extracted from the cancerous and non-cancerous tissues of six clear cell RCC cases, and transcribed to cDNA. The cDNA was synthesized and subjected to digestion with the restriction enzymes MspI or MseI, followed by adapter ligation. Selective PCR by 256 kinds of primer pairs was used to amplify the HiCEP fragments, and products with fluorescently-labeled primer were then analyzed by capillary electrophoresis. HiCEP fragments were sequenced using a next-generation sequencer (ion PGM, Thermo Fisher Scientific). We compared the expression levels of HiCEP peaks in cancerous tissues with those in non-cancerous tissues. Results: We detected several HiCEP peaks in cancerous tissues that showed five times higher expression than in normal tissues. We determined the sequences of the HiCEP fragments by NGS, and developed the first ever cancerous tissue HiCEP fragment database. Conclusion: We successfully established an RCC gene expression database by NGS-combined HiCEP. We are now performing replication analyses and further analyses of blood samples from the same RCC cases to be able to identify diagnostic and prognostic markers of RCC. Citation Format: Makoto Kawaguchi, Hirotaka Matsuo, Ryoko Araki, Seiko Shimizu, Mikiya Takao, Akiyoshi Nakayama, Yosuke Kitamura, Masumi Abe, Keiichi Ito, Nariyoshi Shinomiya. Development of a gene expression database of renal cell carcinoma cases by NGS-combined HiCEP to identify tumor markers [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 5237.
Thrombophlebitis with diazepam used intravenously
Authors: D. E. Langdon
Journal: JAMA (1973)

In more than 1,500 intravenous administrations of diazepam (Valium) for gastrointestinal endoscopy, an incidence of thrombophlebitis of approximately 3.5% resulted. In a few cases, the phlebitis was protracted and involved a long segment of vein. We now recommend that small veins or hand veins be avoided. If the vein is painful after injection, vigorous flushing of the vein is indicated. Administration of heparin sodium for two to three days is effective, and this therapy should be considered in more severe cases. Preliminary results of a randomized prophylactic-flush study indicate decreased severity with flushing.