tbuckley/cabot-search huggingface dataset:
Hearing Aid Effect in Unilateral Conductive Deafness
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Zonal heterogeneity of peroxisomal enzymes in rat liver: Differential induction by three divergent hypolipidemic drugs
Authors: M Lindauer
Journal: Hepatology (1994)

The hepatic zonation of peroxisomes and four of their matrical enzyme proteins (catalase, acyl coenzyme A oxidase, multifunctional protein, thiolase) has been investigated in normal male rats and after treatment with three divergent hypolipidemic drugs by means of automatic image analysis and quantitative immunoelectron microscopy. The induction of peroxisomal enzymes was confirmed by Western blotting and enzyme activity determinations in liver homogenates and in highly purified peroxisome fractions. In control animals the volume density of peroxisomes and the concentrations of all four enzymes were comparable across the liver acinus. The treatment with all three compounds induced stronger proliferation of peroxisomes in zone 3 than in zone 1 hepatocytes, and significant differences between the different compounds were detectable only in pericentral hepatocytes. The immunolabeling density reflecting the enzyme protein concentration in the peroxisomal matrix was unchanged or reduced for catalase but showed significant elevations for β-oxidation enzymes in treated animals. It did not increase, however, in parallel with the augmentation of the volume density but showed a different pattern for each enzyme, depending on the acinar location and the type of compound used, suggesting a complex fine regulation for each protein. The total labeling index, reflecting the total amount of each protein, was for almost all enzymes higher in perivenous hepatocytes, indicating that they respond more intensely to hypolipidemic drugs than periportal cells. The elevations of the peroxisomal enzymes in zone 3 of the acinus may contribute to the perturbation of the sterol and bile acid metabolism associated with hypolipidemic therapy. (Hepatology 1994;20:475–486.)
THE REVIEWING OF BOOKS.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
HOSPITAL SPREAD OF SMALLPOX.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A THALLOPHYTIC BLOOD PARASITE ASSOCIATED WITH REMITTENT AND OTHER FEVERS.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
1097P 4-year relapse-free survival (RFS), overall survival (OS) and long-term toxicity of (neo)adjuvant ipilimumab (IPI) + nivolumab (NIVO) in macroscopic stage III melanoma: OpACIN trial
Authors: J.M. Versluis, I.L.M. Reijers, E.A. Rozeman, K. Sikorska, W.J. van Houdt, J.V. van Thienen, S.A. Adriaansz, H. Mallo, H. van Tinteren, B.A. van de Wiel, L.G. Grijpink-Ongering, A. Bruining, J.B.A.G. Haanen, A.C.J. van Akkooi, T.N. Schumacher, C.U. Blank
Journal: Annals of Oncology (2020)
DIAPHRAGMATIC HERNIA DIAGNOSED DURING LIFE
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PTU-043 Development of a liver-specific, tumour-selective recombinant adeno-associated virus vector to target hepatocellular carcinoma
Authors: M Della Peruta, C Binny, D Nathwani, J McIntosh, C Rosales, A M Davidoff, R Williams, S Chokshi, A C Nathwani
Journal: Gut (2012)

<h3>Introduction</h3> Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide and is currently one of the most difficult to treat. Surgical resection and liver transplantation are considered curative therapies but they are feasible for only a small number of patients. Other therapeutic options, such as radiofrequency ablation and arterial chemoembolization, are effective only in small tumours. Recombinant adeno-associated virus (rAAV) vectors are ideally suited for gene transfer-based therapeutic approaches for HCC because of their safety profile and remarkable tropism for the liver, with &gt;90% of the vector particles being detectable in hepatocytes following a single systemic administration in non-human primates. <h3>Methods</h3> Sequence complementarity to <i>miR-122a</i> (122aT) was cloned downstream of luciferase under the control of a new liver specific promoter/enhancer element, HLP, and flanked by the AAV-inverted-terminal-repeats (ITRs). AAV8 capsid-pseudotyped AAV8-HLP-LUC±122aT vector stocks were prepared by 293T-based three-plasmid transient transfection, and used for: in vitro transduction of HCC cell lines HUH-7 (miR-122a-positive) and SNU-387 (miR-122a-negative); in vivo tail vein injection of tumour-bearing SCID and B6 mice. <h3>Results</h3> A single tail-vein injection of rAAV8 in tumour-bearing mice resulted in selective transduction of the liver as well as of HCC, but not neuroblastoma xenografts. We cloned the 122aT into our expression cassette to improve the transgene expression for HCC, taking advantage of the differential expression of miR-122a (abundant in normal liver but down regulated in most HCC). Normalised transgene expression with AAV8-HLP-LUC-122aT was at least 26.5-fold higher in SNU-387 when compared to HUH-7 cell lines. Tail-vein injection of rAAV8-HLP-LUC resulted in high transgene expression in liver, but mice transduced with rAAV8-HLP-Luc-122aT had little or no luciferase expression despite the proviral DNA presence. Subcutaneous HCC xenografts in mice showed a strong luciferase signal following tail-vein injection of both of these vectors. <h3>Conclusion</h3> Inclusion of 122aT in the expression cassette allows regulation of rAAV mediated transgene expression in HCC cell lines and normal liver, and reduces expression in miR-122a positive cells (eg, normal hepatocytes). This novel vector, therefore, has the potential to deliver therapeutic transgenes to HCC in preference to normal hepatocytes in the liver, thus limiting toxicity. <h3>Competing interests</h3> None declared.
Kundumani-Sridharan V, Niu J, Wang D, et al. 15(S)-hydroxyeicosatetraenoic acid–induced angiogenesis requires Src-mediated Egr-1–dependent rapid induction of FGF-2 expression. <i>Blood</i>. 2010;115(10):2105-2116.
Journal: Blood (2021)
AVICENNA
Journal: JAMA (1961)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Relation of pulse pressure to carotid and left ventricular geometry in hypertension Pietro Sanna, Antonello Ganau, Pier Sergio Saba, *Mary J. Roman, Luciano Petretto, Giampaolo Sanna, *Riccardo Pini, *Richard B. Devereux. Clinical Medicine, University of Sassari, Sassari, Italy, *Weill Medical College of Cornell University, New York, NY
Journal: Journal of the American College of Cardiology (2001)
Data Processing Error in: Fluoxetine After Weight Restoration in Anorexia Nervosa: A Randomized Controlled Trial
Authors: Jeffrey Weitzel, Veronica Lagos, Deborah Macdonald, Gwen Uman
Journal: JAMA (2007)

ity, specificity, positive predictive power, negative predictive power, and the C statistic) that we and others have used to compare mutation prediction models, 1,4 the ability to examine multiple predictors in logistic regression can add depth of understanding to statistical results.We agree that the corrective probability index we created was not based on a theory of inheritance but, rather, was a temporizing measure to improve the sensitivity of the model, hopefully to be replaced by a model wherein the parameters are adjusted for accuracy for single-case indicators in clinical settings such as ours.We intend to validate the effect of family structure in additional clinical and population-based data sets.BRCAPRO certainly has great value in estimating the proportion of a population with a BRCA mutation and, in particular, in assigning likely carrier status when test results are uninformative.However, we maintain that from the clinician's perspective, neither BRCAPRO nor any of the other models tested is adequately accurate to determine whether to offer BRCA testing for a single case of breast cancer, especially in the setting of limited family structure.While model-driven estimates have an important role as a component of the genetic cancer risk assessment process, we believe that the use of single point estimates as a threshold for recommending genetic testing should be discouraged in favor of a clinical judgment-grounded approach.This is consistent with the updated American Society of Clinical Oncology guidelines 5 and is critically important to individual women contemplating the benefits of risk reduction.
Stale, Soft, or Chronic
Authors: E. J. H.
Journal: Annals of Internal Medicine (1969)

Editorials1 June 1969Stale, Soft, or ChronicE. J. H.E. J. H.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-70-6-1272 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPhysicians in Rochester, N. Y., have recently provided evidence (1) confirming again that mental and emotional disorders are a sizeable fraction of problems presented by patients. The data were reported by 29 internists and 29 general practitioners from a population of 14,117 white adult patients. The highest rate, 25%, of psychiatric disorders was in women between ages 35 and 54. Men between ages 15 to 24 and 65 to 99 had the lowest rate, 7%. The overall rate was 14%. The rates reported by internists and by general practitioners did not differ. The therapeutic challenge from these patients is implicit...References1. LOCKEGARDNER BAEA: Psychiatric disorders among the patients of general practitioners and internists. Public Health Rep. 88: 167, 1969. CrossrefGoogle Scholar2. HILL D: Psychiatric education during a period of social change. Brit. Med. J. 1: 205, 1969. CrossrefMedlineGoogle Scholar3. Editorial: Progress in Australian population studies. Med. J. Aust. 1: 303, 1969. CrossrefMedlineGoogle Scholar4. ACP Postgraduate Questionnaire Results. Bull. Amer. Coll. Physicians 10: 48, 1969. Google Scholar5. VINCENTROBINSONLATT MOEAL: Physicians as patients: private psychiatric hospital experience. Canad. Med. Ass. J. 100: 403, 1969. MedlineGoogle Scholar6. MENNINGERMAYMANPRUYSER KMP: The Vital Balance: The Life Process in Mental Health and Illness, The Viking Press, Inc., New York, 1963. Google Scholar7. LIDZ T: The Person: His Development Throughout the Life Cycle, Basic Books, New York, 1968. Google Scholar8. STEIGERHANSEN WAAV: Patients Who Trouble You, Little, Brown and Co., Boston, 1964. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byModels for teaching communication and attitudesFactors Related to the Incidence of Psychosomatic IllnessA response to the anti-psychiatry movementOutlook for Treating Patients with Self-Destructive HabitsJOHN F. BURNUM, M.D., F.A.C.P.The Epidemiology of Psychosomatic DisordersDoctor and nurse: changing roles and relationshipsThe Use of a Therapeutic Milieu on a Continuing Care Unit in a General HospitalREDFORD B. WILLIAMS JR., M.D., ELLEN M. OVERLAN, JANE H. RYZEWSKI, R.N., MARILYN J. BEACH, R.N., HAROLD N. WILLARD, M.D., F.A.C.P.Emotional Disorders in Medical PracticeELMER A. GARDNER, M.D.Doctor and Nurse: Changing Roles and Relations 1 June 1969Volume 70, Issue 6Page: 1272-1275KeywordsAdultsEmotionsResearch design Issue Published: 1 June 1969 PDF downloadLoading ...
Attachment behavior in hospitalized patients
Authors: R. M. Berlin
Journal: JAMA (1986)

ILLNESS and hospitalization are major stresses that mobilize intense fears: fears of death, injury, loss of control, stranger anxiety, and separation anxiety. Despite these stresses, most people will enter the hospital and assume the patient role. One important way people adapt to the patient role is by finding a physician who explains their symptoms in a way they can understand. The physician occupies a social position of respect, reverence, and influence comparable with the parental role.<sup>1</sup> Many theoretical models (paternalism, legal, economic, religious, physician conscience)<sup>2-4</sup>have been proposed to explain the relationship between the physician and the patient. The concept of transference, the unconscious assignment to others of feelings and attitudes that were originally associated with important figures in one's early life, is usually invoked as a major underpinning of the physician-patient relationship. Another model, which complements and extends other notions about interactions between physicians and their patients,
Regulation of Functional Cytodifferentiation and Histogenesis in Mammary Epithelial Cells: Role of the Extracellular Matrix
Authors: Mina J. Bissell, Tracy G. Ram
Journal: Environmental Health Perspectives (1989)

Primary mammary epithelial cells provide a versatile system for the study of hormone and extracellular matrix (ECM) influences on tissue-specific gene expression. We have characterized the formation of alveolarlike morphogenesis and mammary-specific functional differentiation that occur when these cells are cultured on a reconstituted basement membrane (EHS). Cells cultured on EHS exhibit many ultrastructural and biochemical features indicative of polarized and functionally differentiated mammary epithelium in vivo. The increased expression and specific vectorial secretion of milk proteins into lumina formed in culture are accompanied by large increases in milk protein mRNA expression. However, when individual ECM components are tested, smaller increases in milk protein mRNA are measured on heparan sulfate proteoglycan (HSPG) and laminin, and these responses are not associated with full functional cytodifferentiation or histotypic configuration. This indicates that multiple levels of regulation are involved in mammary-specific gene expression, and that in addition to individual ligand requirements cooperative interactions between various ECM molecules and cells are necessary for functional differentiation in culture. We have also shown that endogenous production of ECM molecules and changes in cell geometry are correlated with changes in functional and histogenic gene expression. We have previously proposed a model of cell-ECM interactions that is consistent with these data.
Erratum: Galectin-3 Promotes Vascular Remodeling and Contributes to Pulmonary Hypertension
Authors: Robinder Khemani, Nadir Yehya, Anoopindar Bhalla, Neal Thomas, Christopher Newth
Journal: American Journal of Respiratory and Critical Care Medicine (2018)

harm.To definitively prove this and change practice, we should first "walk" with a randomized controlled trial comparing usual care with PEEP/FI O 2 grid-based management.We agree that this PEEP/FI O 2 table may not be the final best approach to PEEP management, but these more individualized methods should be compared with PEEP/FI O 2 grid-based management to determine whether the additional complexity required by these more individualized approaches, which are not consistently used in clinical PARDS practice, translates into improved clinical outcomes.
Food-borne streptococcal pharyngitis in a hospital pediatrics clinic
Authors: M. D. Decker
Journal: JAMA (1985)

After a potluck luncheon, more than half the staff of a hospital pediatrics clinic became ill. Group A<i>Streptococcus</i>(M precipitin, nontypable; T agglutination type, 8/25; and serum opacity reaction, positive) was isolated from 12 of the 20 ill persons. Food-consumption analysis implicated a rice dressing as the vehicle of transmission. The dressing was prepared by a clinic employee in whom pharyngitis had developed three weeks before the luncheon. This is an unusual outbreak in that the implicated food product was not institutionally or commercially prepared and was not preponderantly composed of milk, eggs, or meat. (<i>JAMA</i>1985;253:679-681)