tbuckley/cabot-search huggingface dataset:
Epidemiologic Study of Renal Function in Copper Smelter Workers
Authors: Ruth Lilis, Jose A. Valciukas, Jean-Phillipe Weber, Judith Malkin, Irving J. Selikoff
Journal: Environmental Health Perspectives (1984)

A medical cross-sectional examination of a copper smelter work force was undertaken after environmental contamination with lead, cadmium and arsenic had been documented. A total of 920 subjects was examined, including active smelter employees, retired workers and copper mine employees who had never worked in the smelter. Slight to moderate absorption of lead and cadmium was definitely present in the active copper smelter employees, who had significantly higher levels of Pb-B, ZPP and Cd-B than retired employees and miners. Cd-U levels were higher in retired workers, who were also older and had, as a group, longer duration of exposure in the smelter. Cd-U did not exceed 10 micrograms/g creatinine, the level considered critical for nephrotoxicity, in any of the subjects. Median Cd-B level for active workers was 2.75 micrograms/L. Lead absorption was characterized by a relatively small proportion (16.7%) of active employees with Pb-B levels 40 micrograms/dL or higher. We were particularly interested in exploring the possibility that simultaneous exposure to lead and cadmium, although at levels not associated with nephrotoxicity for each metal separately, could result in renal function impairment. Distribution patterns of BUN and serum creatinine levels were unremarkable. Urinary beta 2-microglobulin levels were less than 200 micrograms/g creatinine in 95% of copper smelter employees. There were no significant correlations between urinary beta 2-microglobulin levels and Cd-U, Cd-B, Pb-B and ZPP or between urinary beta 2-microglobulin excretion and serum creatinine or BUN levels. Urinary beta 2-microglobulin levels were significantly correlated with age in the copper smelter workers, but not in the miners. Nevertheless, in the absence of any significant correlations between urinary beta 2-microglobulin and Cd-U, Cd-B, a causal relationship with cadmium absorption cannot be affirmed. That kidney function could be impaired by long-term exposure in the smelter was only indirectly suggested. Effects on renal function at the low levels of cadmium and lead absorption that were observed in this smelter population are minimal.
Long-term follow-up in patients with atrial fibrillation and left atrial thrombi Monika Rameken, Margit Vater, Frank Fischer, Axel Droegemueller, Harald Schwacke, Caroline Bergmeier, Jochen Senges, Karlheinz Seidl. Klinikum Ludwigshafen, Ludwigshafen, Germany
Journal: Journal of the American College of Cardiology (2001)
Suntanning Centers
Authors: Lewis H. Kaminester
Journal: JAMA (1980)

THE DEEP-TANNED look is "in." Americans, perhaps in emulation of Hollywood stars, seem to associate a deep tan with physical attractiveness, good health—even happiness. It is this desire for a golden tan that has stimulated US businessmen to develop the concept of "tanning centers," where people can walk in and get a series of exposures to ultraviolet light (UVL) to develop a suntan. The clients seek golden tans, the owners reap golden revenue, but the longterm effects for the skin of the patient-client are not nearly as bright. <h3>The Fast Buck</h3> The first US tanning center started in Arkansas in 1978. New centers are now opening at a rate of ten per week. Locations are not limited to cold, cloudy climates but include the sunbelt as well. Evidently, many people prefer the convenience of spending two or three minutes in an airconditioned booth several times a week to spending many
Correlates of homosexual behavior and the incidence of anal cancer
Authors: J. R. Daling
Journal: JAMA (1982)

To determine whether characteristics that are correlated with male homosexual behavior are associated with the incidence of cancer, the names of persons with a diagnosis of cancer in western Washington during 1974 to 1979 were linked to those in the state syphilis registry. Eight of 47 men with anal cancer were found to have had a reactive FTA test result; the expected number, based on the proportion of reactive cases among men with other sites of cancer, was only 0.40. Among men with anal cancer identified through ten population-based cancer-reporting systems in the United States, 24.4% had never been married, compared with 7.8% of men with colon and rectal cancer. Neither of these relationships was observed for women with anal cancer. Because in men, but not in women, having had syphilis and being single are associated with the practice of anal intercourse, our data suggest that anal intercourse may be a risk factor for anal cancer. (<i>JAMA</i>1982;247:1988-1990)
THU0261 Continuous nsaid use reverts the effects of inflammation on radiographic progression in patients with ankylosing spondylitis:
Authors: F. Kroon, R. Landewé, M. Dougados, D. van der Heijde
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> In a recent clinical trial it was shown that continued treatment with nonsteroidal anti-inflammatory drugs (NSAIDs), in comparison to on-demand use of NSAIDs, reduced radiological progression in the spine in patients with ankylosing spondylitis.(1) To improve the benefit-risk ratio it is crucial to understand which patients may have most to gain from continuous NSAID-use in terms of radiological progression. <h3>Objectives</h3> The aim of this study was to compare continuous NSAID treatment and on-demand NSAID treatment with respect to their ability to suppress radiographic progression in subgroups of patients with elevated CRP-levels, elevated ESR, high ASDAS-levels or high BASDAI-levels in comparison to patients with normal levels. <h3>Methods</h3> Post-hoc analyses were performed in the above referenced RCT. Relevant subgroups were created by splitting the groups at predefined values considered as high/elevated based on time-averaged (ta) CRP (&gt;5mg/L), ta-ESR (&gt;12mm/hr), ta-BASDAI (&gt;4), ta-ASDAS-CRP (&gt;2.1) and ta-ASDAS-ESR (&gt;2.1). Subgroups were further split according to NSAID-use (continuous vs. on-demand). Statistical interactions were tested using multiple regression analysis. Differences in radiological progression between groups were analysed using the Chi-square and Mann-Whitney U test. <h3>Results</h3> 150 randomized patients (continuous-treatment group (n=76), on-demand group (n=74)) had complete radiographs and were included in the analyses. The effect of slowing radiological progression, both as continuous dmSASSS or % patients progressing ≥2 mSASSS, with continuous NSAID therapy was more pronounced in patients with elevated ta-CRP-levels, elevated ta-ESR, high ta-ASDAS-CRP or high ta-ASDAS-ESR versus patients with low/normal values (p&lt;0.05) (Table). No such effect was found for patients with high vs. low BASDAI. In patients with elevated ta-ESR (irrespective of treatment), structural progression was higher than in patients with normal ta-ESR (p&lt;0.01). Regression analyses showed that continuous NSAID treatment neutralizes the deleterious effects of inflammation (high ta-ESR) (no statistical interaction). <h3>Conclusions</h3> Patients with elevated acute phase reactants benefit most from continuous NSAID treatment. Prioritizing patients with elevated acute phase reactants for continuous NSAID-treatment may improve the benefit-risk-ratio,of NSAID-treatment in AS. <h3>References</h3> Wanders A et al. Arthritis Rheum. 2005;52:1756-65 <h3>Disclosure of Interest</h3> None Declared
Inhibitory actions of cyclic adenosine monophosphate and pertussis toxin define two distinct epidermal growth factor-regulated pathways leading to activation of mitogen-activated protein kinase in rat hepatocytes
Authors: P Gines
Journal: Hepatology (1996)

Increased intracellular cyclic adenosine monophosphate (cAMP) levels have been shown in some reports to inhibit and in other studies to stimulate growth factor-mediated activation of the mitogen-activated protein kinase (MAP kinase) pathway, depending on the cell type examined. The relationship between cAMP and MAP kinase in hepatocytes has not been examined. In the current study, stimulation of primary cultures of rat hepatocytes with hepatocyte growth factor (HGF) or epidermal growth factor (EGF) increased Ras, Raf, and MAP kinase activity. Incubation of hepatocytes with cAMP-increasing agents blocked activation of Raf by both HGF and EGF, whereas activation of Ras was unaffected. MAP kinase activation by HGF was completely inhibited, whereas EGF-stimulated MAP kinase activity was only slightly reduced. Incubation of hepatocytes with pertussis toxin slightly blunted MAP kinase activation by EGF but not HGF. Increasing cAMP in hepatocytes preincubated with pertussis toxin completely inhibited the activation of MAP kinase by EGF. In conclusion, HGF activates MAP kinase in hepatocytes exclusively through an Raf-dependent pathway and this activation may be completely blocked by increasing cAMP. In contrast, EGF activates MAP kinase in hepatocytes through both Raf-dependent and Raf-independent pathways: the latter pathway probably involves a pertussis toxin–sensitive G protein.
FUNGOUS DISEASES
Authors: J. T. Ingram
Journal: BMJ (1959)

The ability of fibroblasts to contract three-dimensional collagen gels has been used as an <i>in vitro</i> model of the tissue contraction which characterises both normal repair and fibrosis. Among its actions, thrombin can activate the protease-activated receptor (PAR)1 and, thereby, stimulate inflammation and repair. The current study evaluated whether thrombin could stimulate fibroblast-mediated collagen gel contraction by activating PAR1 and whether its downstream signalling depends on protein kinase C (PKC)-ϵ. Human foetal lung fibroblasts (HFL-1) were cultured in three-dimensional collagen gels and the area of the gels was measured by image analyser. Both thrombin and TFLLR, a selective PAR1 agonist, stimulated collagen gel contraction mediated by HFL-1. After RNA interference-mediated PAR1 knockdown in HFL-1, both thrombin and the PAR1 agonist-induced gel contraction were partially inhibited (by 22.4±2.2% and 17.6±5.6%, respectively). The gel contraction stimulated by thrombin was also reduced by a nonspecific PKC inhibitor and a calcium-independent PKC-ϵ inhibitor. Both thrombin and TFLLR significantly increased PKC-ϵ activity, and this effect was blocked by PAR1 knockdown. Thrombin stimulates collagen gel contraction at least partially through activation of protease-activated receptor 1 and protein kinase C-ϵ, and may contribute to tissue remodelling in inflammatory airway and lung diseases.
THE PASSING OF KERR.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Erratum: Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice
Authors: Stacey R Dillon, Cindy Sprecher, Angela Hammond, Janine Bilsborough, Maryland Rosenfeld-Franklin, Scott R Presnell, Harald S Haugen, Mark Maurer, Brandon Harder, Janet Johnston, Susan Bort, Sherri Mudri, Joseph L Kuijper, Tom Bukowski, Pamela Shea, Dennis L Dong, Maria Dasovich, Francis J Grant, Luann Lockwood, Steven D Levin, Cosette LeCiel, Kim Waggie, Heather Day, Stavros Topouzis, Janet Kramer, Rolf Kuestner, Zhi Chen, Don Foster, Julia Parrish-Novak, Jane A Gross
Journal: Nature Immunology (2004)
Book Listings
Journal: Annals of Internal Medicine (2002)

Book Listings1 January 2002Book ListingsSearch for more papers by this authorhttps://doi.org/10.7326/0003-4819-136-1-200201010-00020 SectionsAboutFull Text ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Cardiology100 Questions in CardiologyD Holdright and H Montgomery, eds. 222 pages. London: BMJ; 2001. $42.00. ISBN 0727914898. Order phone 011-44-171-387-4499.ABC of Hypertension4th edition. G Beevers, GY Lip, and E O'Brien. 108 pages. London: BMJ; 2001. $25.00. ISBN 0727915223. Order phone 011-44-171-387-4499.Advances in the Treatment of Atrial Tachyarrhythmias: Pacing, Cardioversion, and DefibrillationCW Israel and S Barold, eds. 446 pages. Armonk, NY: Futura; 2002. $127.00. ISBN 0879934972. Order phone 800-877-8761.Cardiac Arrhythmias after Surgery for Congenital Heart DiseaseS Balaji, PC Gillette, and CL Case, eds. 360 pages. Boston: Arnold; 2001. $99.00. ISBN 0340762071. Order phone 800-368-5777.Cardiac Pacing and ... PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 January 2002Volume 136, Issue 1 Page: B1 ePublished: 1 January 2002 Issue Published: 1 January 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.Loading ...
Erratum: Mig6 is a negative regulator of EGF receptor–mediated skin morphogenesis and tumor formation
Authors: I Ferby, M Reschke, O Kudlacek, P Knyazev, G Pantè, K Amann, W Sommergruber, N Kraut, A Ullrich, R Fässler, R Klein
Journal: Nature Medicine (2006)
Pharmacology
Journal: JAMA (1910)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A horizon scan of global conservation issues for 2012
Authors: William J. Sutherland, Ros Aveling, Leon Bennun, Eleanor Chapman, Mick Clout, Isabelle M. Côté, Michael H. Depledge, Lynn V. Dicks, Andrew P. Dobson, Liz Fellman, Erica Fleishman, David W. Gibbons, Brandon Keim, Fiona Lickorish, David B. Lindenmayer, Kathryn A. Monk, Kenneth Norris, Lloyd S. Peck, Stephanie V. Prior, Jörn P.W. Scharlemann, Mark Spalding, Andrew R. Watkinson
Journal: Trends in Ecology & Evolution (2011)
Cardiac Arrhythmias--Self Learning
Journal: Thorax (1987)

We are also concerned about the lymph node sections that the authors had available for study from a series going back to 1949 and not collected specifically to display the lymph nodes.It is crucial to look for changes in and around the appropriate node or nodes when progressive massive fibrosis or secondary foci are confined to one area of the lung (as we illustrated in our paper), and this does not appear to have been considered in the Australian study.In our study we were aware that histological assessments were "under- estimating" changes in and around lymph nodes because of the difficulty of obtaining sufficient sections (for example, to include a branch of the pulmonary artery), and it is likely that this was also a problem in the study of Drs Leigh and Wiles.We agree that dust exposure (however estimated) is an important factor associated with progressive massive fibrosis and this has been demonstrated repeatedly.Yet dust exposure is not the only factor concerned and some men seem more "susceptible" than others.Our paper suggested a mechanism for the production of progressive massive fibrosis in individual men.We feel that careful prospective studies are now required to examine this hypothesis further.
An Address Delivered at the Opening of the Section of Obstetric Medicine
Authors: W. O. Priestley
Journal: BMJ (1877)

I8Inot only in infancy, but even in our student days, early impressions are imprinted indelibly on our memory.I had the good fortune to be one of the first set of dressers for Mr. Hilton when he was app6inted one of the surgeons to Guy's Hospital, about the year i845.No one at that time was more ready or more able to apply correct anatomical knowledge to surgical practice than he.It was his delight, as his chef d'a'uvre on Rest and Pain will fully testify.At this time he had under treatment a young woman with necrosis of the lower part of the ulna, without, as was then thought, any present disease in the carpal joints.Mr. Hilton said, "How would it do to take away the diseased bone, and not destroy the integrity of the carpus, by carefully leaving intact the triangular fibro-cartilage which intervenes between the end of the ulna and the cuneiform bone?"This was done, and a perfect recovery resulted.The fact thus presented to my mind was never forgotten.I referred to it from time to time in my anatomical demonstrations, as a possible operation.It was not until quite recently, however, that I had a precisely similar case to treat, one in which, as you will observe, I have removed the lower inch of the ulna without disturbing any of the carpal joints.Recovery has
Studies on Intermittent Corticosteroid Dosage Regimen
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
WILLIAM HOGARTH (1697-1764): MORALIST-ENGRAVER
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Painful Joints
Authors: Murray L. Janower
Journal: JAMA (1964)

Dr. Jack Wittenberg: The patient is a 57-year-old white male who entered the Massachusetts General Hospital for the third time because of a swollen, painful right wrist, elbow, and shoulder. His history dates back 11 years prior to admission when he first noted right hip pain, which he described as "grinding" in nature. The pain would last for one to three days, subside spontaneously, and then recur in a month or so. About six years before admission, the patient noted acute neck pain which radiated to both shoulders. Roentgenograms at that time were reported to have shown calcific deposits about both shoulders. He was treated with traction and improved somewhat. Three years prior to admission the patient noted the sudden onset of pain in his left forearm followed by swelling, tenderness, redness, and warmth in the wrist. The arm was placed in a cast which was removed in several days;
Progress in Cardiovascular Diseases, New York
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal