tbuckley/cabot-search huggingface dataset:
Tissue Typing, Leukocyte Antigen Tests May Be Keys to Compatible Transplants
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Corneille Heymans (1892-1968)
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MEETINGS
Journal: Annals of Internal Medicine (1961)

Medical News1 June 1961MEETINGSAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-54-6-lxxxvii SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPOSTGRADUATE COURSESMICHAEL REESE HOSPITAL AND MEDICAL CENTER, CHICAGO, ILL.A course in electrocardiographic interpretation for graduate physicians will be given at the Michael Reese Hospital by Louis N. Katz, M.D., and Alfred Pick, M.D. (respectively Director and Associate Director of the Cardiovascular Department) and Associates. The class will meet daily from 9:00 A.M. to 5:00 P.M., July 17th through July 29th.Further information and a copy of the lecture schedule may be obtained upon application to Miss Beverley Petzold, Secretary, Cardiovascular Department, Medical Research Institute, Michael Reese Hospital and Medical Center, Chicago 16, Illinois.FITZSIMONS GENERAL HOSPITAL, DENVER, COLO. This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1961Volume 54, Issue 6Page: lxxxvii-xciiKeywordsElectrocardiographyGraduate medical education ePublished: 1 December 2008 Issue Published: 1 June 1961 PDF downloadLoading ...
Diseases of Bone and Joints
Authors: Reginald R. Cooper
Journal: JAMA (1970)

To produce a "concise, yet informative, comprehensive survey" of skeletal disease—the author's avowed objective—indeed presents a formidable venture. To correlate pathology with clinical manifestations, roentgenograms, and treatment greatly increases the magnitude of the task. Years of intense interest and study qualify the author to undertake such an assignment. The extent and quality of discussion on systematized (by which the author means regionalized or generalized) developmental disorders and histiocytosis proclaim careful observation of these maladies. In discussions of metabolic and endocrine disorders, recent biochemical and experimental data illuminate traditional and at times cursory pathology concepts. The more frequent degenerative and traumatic diseases receive less attention. The section on infection regrettably lacks clarity on the role of surgery in treatment. Several "common and unusual" conditions discussed in only one or two hasty sentences might better have been omitted. Despite numerous excellent radiographs and gross photographs and some clinical discussion, this book does
Myocardial Contusion Not Always Recognized As Cause of Death in High-Speed Auto Accidents
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Childbirth History
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Randomized, open-label, perioperative phase II study evaluating nivolumab alone versus nivolumab plus ipilimumab in patients with resectable HCC.
Authors: Ahmed Omar Kaseb, Roberto Carmagnani Pestana, Luis M. Vence, Jorge M. Blando, Shalini Singh, Naruhiko Ikoma, Jean-Nicolas Vauthey, James Patrick Allison, Padmanee Sharma
Journal: Journal of Clinical Oncology (2019)

185 Background: In HCC, surgical resection is associated with high recurrence rate, and no effective neoadjuvant or adjuvant therapies currently exist. On the basis of previous reports on the efficacy and safety of anti–PD-1 and anti–CTLA-4 antibodies against HCC, we initiated a randomized pilot trial of perioperative immunotherapy for resectable HCC. Methods: This is a randomized, phase II trial of nivolumab (Arm A) or nivolumab + ipilimumab (Arm B) as peri-operative treatment for patients (pt) with HCC who are eligible for surgical resection. Pt are given nivolumab 240 mg every 2 weeks (wk) for a total of 6 wk. Pt in Arm B are treated concurrently with ipilimumab 1 mg/kg every 6 wk. Surgical resection occurs within 4 wkafter last cycle of therapy. Pt continue adjuvant immunotherapy for up to 2 years after resection. Primary objective is the safety and tolerability of nivolumab +/- ipilimumab. Secondary objectives include overall response rate, complete response rate and time to progression. Exploratory objectives include evaluating the pre- and post-treatment immunological changes in tumor tissues and peripheral blood. Results: 9 pt were enrolled at the time of first interim analysis, and 8 pt were evaluable (5 in Arm A, 3 in Arm B). Pt were 60-69 yo, and males (78%). 5 pt were HCV-positive and 1 had chronic hepatitis B infection. 8 pt proceeded with resection as planned; surgery was aborted for 1 pt due to frozen abdomen from previous surgery. Pathologic complete response (pCR) was observed in 3/8 pt – 2 in Arm A and 1 Arm B (37.5% pCR). 2 pt in Arm B and 1 in Arm A experienced grade 3 or higher toxicity which did not affect their resectability. No grade 4 or higher toxicity were observed. Immune analysis of the first case with a pCR in Arm B demonstrated that clinical response correlated with an increase in CD8+ T cell infiltration, notably an increase in two effector T cell clusters. Conclusions: We report a pCR rate of 37.5% in the first interim analysis of a phase II pilot trial of perioperative immunotherapy for resectable HCC. Treatment was deemed safe and surgical resection was not delayed. The study is ongoing and results may contribute to a paradigm shift in the perioperative treatment of HCC. Clinical trial information: NCT03222076.
Radiological Assessment of Thymic Size in Myasthenia Gravis and Systemic Lupus Erythematosus
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ceti
Authors: Lewis Thomas
Journal: New England Journal of Medicine (1972)

TAU Ceti is a relatively nearby star that sufficiently resembles our sun to make its solar system a plausible candidate for the existence of life. We are, it appears, ready to begin getting in touch with Ceti, and with any other interested celestial body in more remote places, out to the edge. CETI is also, by intention, the acronym of the First International Conference on Communication with Extraterrestrial Intelligence, held a few months ago in Soviet Armenia under the joint sponsorship of the National Academy of Sciences of the United States and the Soviet Academy, involving eminent physicists and astronomers . . .
GPs giving advice on child safety is effective
Journal: BMJ (1998)

Cognitive behaviour therapy is promising in childhood depressive disorderOver the past 15 years there has been increasing recognition that children suffer depressive conditions.A systematic review concluded that tricyclics were of unproved benefit.On p 1559 Harrington et al present a systematic review of six trials of a common psychological treatment-cognitive behaviour therapy.The results suggest that it may be useful in mild or moderately severe cases of juvenile depression.Studies that compare cognitive behaviour therapy with antidepressant medication are now required.
STATE MEDICINE.
Journal: JAMA (1884)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Aire
Authors: Diane Mathis, Christophe Benoist
Journal: Annual Review of Immunology (2009)

Mutations in the transcriptional regulator, Aire, cause APECED, a polyglandular autoimmune disease with monogenic transmission. Animal models of APECED have revealed that Aire plays an important role in T cell tolerance induction in the thymus, mainly by promoting ectopic expression of a large repertoire of transcripts encoding proteins normally restricted to differentiated organs residing in the periphery. The absence of Aire results in impaired clonal deletion of self-reactive thymocytes, which escape into the periphery and attack a variety of organs. In addition, Aire is a proapoptotic factor, expressed at the final maturation stage of thymic medullary epithelial cells, a function that may promote cross-presentation of the antigens encoded by Aire-induced transcripts in these cells. Transcriptional regulation by Aire is unusual in being very broad, context-dependent, probabilistic, and noisy. Structure/function analyses and identification of its interaction partners suggest that Aire may impact transcription at several levels, including nucleosome displacement during elongation and transcript splicing or other aspects of maturation.
ASSOCIATION NEWS.
Authors: John Marshall
Journal: JAMA (1897)

<h3>Executive or Business Committee.</h3> —The first meeting of this Committee will be held in Parlor C, Hotel Walton, cor. Broad and Locust Streets, Philadelphia, on Monday May 31, 1897, at 5:30 p.m. Subsequent meetings will be held at the same place and hour, unless otherwise ordered by the committee, for the consideration of matters referred to it by theAssociation, and for the transaction of business. L.Duncan Bulkley, M.D., Secretary of Committee. <h3>Medical Aid Section.</h3> —An effort will be made at the approaching Semi-Centennial of theAssociationin Philadelphia, to complete the organization of a Medical Aid Section for the benefit of disabled physicians and of the widows and orphans of physicians, members of the Section, with the coöperation and endorsement of the several State and municipal medical societies; the friends of such Section of a Medical Aid Society hope to organize and have appointed all the officers required
Schwachman or Pearson syndrome
Authors: Şinasi Özsoylu
Journal: American Journal of Hematology (1998)

lymph node involvement with rt ureter compression that required a stent insertion.Brain CT showed a suprasellar lesion involving the diencephalic and chiasmatic regions (Fig. 1a).The patient was treated with CdA (2 hr-infusion of 0.14 mg/kg die × 7 days) and Dexamethasone (0.3 mg/kg die × 4 days).Therapy was well tolerated without significant hematologic toxicity (WHO G4 leukopenia duration, 3 days; no thrombocytopenia).Partial regression of the liver, kidney, and lymph node involvement and complete regression of the brain lesions (Fig. 1b) were documented 1 month later by CT.The patient was discharged on May 24 with complete regression of the neurological symptoms.On June 13 she died from an acute cerebral vascular accident (CVA) of ischemic origin (brain CT not shown).In this patient, a single cycle of CdA induced complete regression of the brain lesion.CVA as a complication of therapy with CdA has not been reported; a relationship between treatment and the final event is unlikely.
A national health program: northern light at the end of the tunnel
Authors: S. Woolhandler
Journal: JAMA (1989)

FEW WOULD dispute that our health care system is deeply troubled. Thirty-seven million Americans are uninsured, health care costs continue their exuberant growth, and bureaucracy increasingly intrudes in the examining room. Opinion on solutions is more divided. We and many colleagues have proposed a sweeping reform of health care financing<sup>1</sup>because we are convinced that lesser measures will fail, as they have for the past quarter century. Expanding Medicaid,<sup>2</sup>mandating that employers provide health benefits,<sup>3</sup>setting up state risk pools, and similar piecemeal attempts to expand access either fuel inflation or install intrusive cost-management bureaucracies—usually both.<sup>4</sup>Providing more care to those currently uninsured must raise costs if resources are not diverted from elsewhere in the system. Unless bureaucracy is trimmed, these resources will be siphoned from existing clinical care, a process invariably overseen by yet another layer of bureaucrats. Medicare epitomizes the problem. It improved access
Joshua Knew
Authors: Liana Roxanne Clark
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Basic nutrition.
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Genetic Testing and Informed Consent
Authors: Roy A. Jensen
Journal: JAMA (1997)

<h3>To the Editor.</h3> —We read with concern and considerable dismay the short discussion about tissue storage and reuse within the review of genetic testing for susceptibility to cancer by Dr Geller and coworkers.<sup>1</sup>What is presented is said to reflect "a number of consensus statements" agreeing that research should be done on banked tumor tissue without specific permission from the patient for the particular questions being asked. It is relevant to note that these "consensus statements" are largely the work of lawyers, bioethicists, and genetic counselors, "many of whom" are narrowly focused and without any direct experience in the science of cancer research. Completely lost within this rush to perceived social correctness is the devastating effect these restrictions would have on the emerging fields of cancer molecular epidemiology and somatic cell cancer genetics. One can only surmise that if these same committees had been charged with fixing a leaky faucet
DR. KINYOUN AND SAN FRANCISCO'S PLAGUE.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal