tbuckley/cabot-search huggingface dataset:
Book Review Acute Injuries of the Head: Their diagnosis, treatment, complications and sequels . By G. F. Rowbotham, B.Sc. (Manch.), F.R.C.S. (Eng.). With a foreword by Norman M. Dott, M.B., Ch.B. (Ed.), F.R.C.S. (Ed.). 8°, cloth, 288 pp., with 124 illustrations. Baltimore: The Williams and Wilkins Company, 1942. $7.50.
Journal: New England Journal of Medicine (1943)
Book Review Radiation and Climatic Therapy of Chronic Pulmonary Diseases: With special reference to natural and artificial heliotherapy, x-ray therapy and climatic therapy of chronic pulmonary diseases and all forms of tuberculosis. Edited by Edgar Mayer, M.D. 8°, cloth, 393 pp., with 46 illustrations. Baltimore: Williams and Wilkins Company, 1944. $5.00.
Journal: New England Journal of Medicine (1945)
New guidelines encourage primary care for patients with early HIV infection
Authors: C. Marwick
Journal: JAMA (1994)

ALTHOUGH there is no cure for AIDS, if people who test positive for antibodies to the human immunodeficiency virus (HIV) are identified early and appropriate treatment is begun, overt disease can be delayed, life can be prolonged, and its quality can be improved. But for this to happen, say federal AIDS experts, primary care physicians and other medical care providers must become involved in caring for patients with HIV infection. To help them do so, the Agency for Health Care Policy and Research (AHCPR) issued its newest clinical practice guideline,<i>Evaluation and Management of Early HIV Infection</i>. The guideline gives primary care providers the information they need to offer early, appropriate care to HIV-positive patients. See also p 492. Because of the evolving nature of knowledge about HIV infection and AIDS, each recommendation in the guideline is rated and labeled according to the degree to which it is based on
Bayesian adaptive randomized trial design for patients with recurrent glioblastoma.
Authors: Brian Michael Alexander, Patrick Y. Wen, Eudocia Quant Lee, Tracy Batchelor, Timothy Francis Cloughesy, Giovanni Parmigiani, Lorenzo Trippa
Journal: Journal of Clinical Oncology (2012)

2005 Background: Bayesian-based trial design has the ability to utilize accumulating data in real time to alter the course of the trial, thereby enabling dynamic allocation to experimental arms and earlier dropping of ineffective arms. This flexibility results in a potentially more efficient trial framework by increasing the probability of enrollment to arms that show evidence of efficacy. In this study we considered a hypothetical scenario in which patients who have been previously treated on several separate experimental protocols at the Dana-Farber/Harvard Cancer Center and the University of California, Los Angeles were instead enrolled in a single multi-arm protocol utilizing a Bayesian adaptively randomized trial design. The purpose was to determine whether similar scientific results could have been accomplished more efficiently. Methods: We generated an adaptive randomization procedure that was retrospectively applied to primary patient data from four separate phase II clinical trials in patients with recurrent glioblastoma. We then compared AR to more conventional trial designs using realistic hypothetical scenarios consistent with survival data reported in the literature. Our primary endpoint is the number of patients needed to achieve a desired statistical power. Results: If our phase II trials had been a single multi-arm AR trial, bevacizumab would have been identified as an efficacious therapy, and 30 fewer patients would have been needed compared to a multi-arm balanced randomized (BR) design. More generally, Bayesian AR trial design for patients with glioblastoma would result in trials with fewer overall patients with no loss in statistical power, and in more patients randomized to effective treatment arms. For a trial with a control arm, two ineffective arms and one effective arm with hazard ratio 0.6, a median of 47 patients would be randomized to the effective arm compared with 35 in a BR design. Conclusions: Given the desire for control arms in phase II trials, an increasing number of experimental therapeutics for patients with glioblastoma, and a relatively short time for events, Bayesian adaptive designs are attractive for clinical trials in glioblastoma.
Factors Associated with Normal Blood Pressure after Surgery To Treat Primary Aldosteronism
Journal: Annals of Internal Medicine (2001)

Summaries for Patients21 August 2001Factors Associated with Normal Blood Pressure after Surgery To Treat Primary AldosteronismSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-135-4-200108210-00006 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?The adrenal glands are small organs located near the kidneys. The adrenal glands make several hormones, including aldosterone, which helps to regulate blood pressure and kidney function. Adenomas are noncancerous tumors that can develop in the adrenal glands. These tumors produce abnormally high amounts of the hormone aldosterone (hyperaldosteronism), a condition known as primary aldosteronism. Among other things, people with primary aldosteronism develop high blood pressure. Surgery to remove the adrenal gland that has the adenoma cures between 30% and 60% of cases of primary aldosteronism. It is ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Primary Aldosteronism: Factors Associated with Normalization of Blood Pressure after Surgery.” It is in the 21 August 2001 issue of Annals of Internal Medicine (volume 135, pages 258-261). The authors are AM Sawka, WF Young Jr., GB Thompson, CS Grant, DR Farley, C Leibson, and JA van Heerden.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine. Previousarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoPrimary Aldosteronism: Factors Associated with Normalization of Blood Pressure after Surgery Anna M. Sawka , William F. Young Jr. , Geoffrey B. Thompson , Clive S. Grant , David R. Farley , Cynthia Leibson , and Jon A. van Heerden Metrics 21 August 2001Volume 135, Issue 4Page: I-32KeywordsAdenomasAdrenal glandsAldosteroneBlood pressureHormonesKidneysPatientsPrimary hypertensionSurgery ePublished: 21 August 2001 Issue Published: 21 August 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Regulation of animal experimentation: an apology
Authors: T. D. Overcast
Journal: JAMA (1986)

<h3>In Reply.—</h3> Dresser makes a number of assertions that are generally already covered in our examination of the regulation of animal experimentation. However, we think it is necessary to respond to several of her comments because they illustrate a more general failure on the part of Dresser and others to understand and appreciate the real issues and interests that are at the heart of this controversy. We take strong exception to Dresser's statement that we see no legitimate reason for the current debate over animal experimentation. In fact, we quite clearly recognize that "few would argue that animal rights advocates have certain concerns that must be seriously addressed by the scientific community." The point that we make repeatedly is that recent proposals for additional regulation are<i>not</i>satisfactory means to address these concerns. Thus, our attitude is hardly a serious threat to biomedical research. On the contrary, we believe that
MEDICAL LEGISLATION.
Authors: Thad. M. Stevens
Journal: JAMA (1884)

<h3>Editor of the Journal of the American Medical Association.</h3> In the issue of your Journal of April 5, under head of " Legal Regulation of the Practice of Medicine," a physician of Indiana offers an article from which we cull two points, viz.: First. That the doctor thinks the medical men, members of the Legislature, could not agree as to the minutiæ of a bill to regulate the practice, and therefore efforts in that direction failed, and that any bill presented should be endorsed by the lay members. Second. He advises the American Medical Association to formulate a bill or to advise as to provisions for such. As to the first proposition, we think the doctor is correct, and this is the principal reason why, as chairman of Committee on State Medicine for Indiana, we advised, and the Committee reported to the State Medical Society, session of 1883, that no bill
Research turns to perhaps overlooked osteocytes in efforts to find answers to osteogenesis puzzle
Authors: T. Randall
Journal: JAMA (1992)

A NEW PARADIGM of osteogenesis has emerged in recent years, and focused in the research spotlight is a "forgotten" group of cells, embedded in bone tissue, called osteocytes. Through studies that are just now taking shape, scientists hope to learn how these cells help bones sense and respond to mechanical use, and how hormones might regulate this tightly coordinated process. Bones bend under everyday use by microscopic amounts that scientists measure in units called microstrains. It is thought that bones regulate their mass so that there is a constant degree of bending under the strain of normal use, says Robert Recker, MD, professor of medicine and director of the Center for Hard Tissue Research, Creighton University School of Medicine. If a bone sense strain beyond this optimal degree of bending, it responds by building more bone, Recker says. Likewise, if a bone senses it is not bending enough, it tears
Lectures on Mental Diseases.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
REPORT OF A CONFERENCE OF STATE AND MUNICIPAL BOARDS OF HEALTH HELD AT CHICAGO, THURSDAY, JANUARY 14, 1892.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effects of Asbestos on the Random Migration of Rabbit Alveolar Macrophages
Authors: Quentin N. Myrvik, E. Ann Knox, Mark Gordon, Pamela S. Shirley
Journal: Environmental Health Perspectives (1985)

The toxicity of sized and characterized chrysotile, crocidolite, and amosite preparations obtained from Dr. K. R. Spurny have been evaluated using alveolar macrophage (AM) migration inhibition assays and viability tests. These results have been compared with asbestos samples obtained from the National Institute of Environmental Health Sciences (NIEHS). These latter samples are designated chrysotile A (RT), crocidolite (RT), and amosite (RT). In addition, filter-isolated preparations of chrysotile A (RT) that consisted mainly of large nonphagocytosable fibers were also tested. Chrysotile (Spurny) and sonicated chrysotile A (RT) produced 50% migration inhibition at about 115 micrograms/mL. Spurny crocidolite produced 50% migration inhibition at about 340 micrograms/mL, whereas RT crocidolite produced 50% migration inhibition at about 230 micrograms/mL. RT amosite caused 50% migration inhibition at about 180 micrograms/mL, whereas Spurny amosite was inactive up to 500 micrograms/mL. The large nonphagocytosable chrysotile A (RT) fibers produced 50% migration inhibition at about 66 micrograms/mL. This indicates that fibers can be toxic for AM through extracellular membrane contact. In general the results from the viability studies paralleled the migration inhibition observations. None of the asbestos preparations induced a burst in the hexose monophosphate shunt of BCG-immune AM at 1 mg/mL. BCG-immune AM were more susceptible to cell death than normal AM when incubated with chrysotile A (RT), amosite (RT) and zymosan. Migration inhibition induced by asbestos fibers probably reflects toxicity of the asbestos preparations and could play an important role in blocking normal alveolar clearance of inhaled particles.
Q6H
Authors: Harry C. Shirkey
Journal: JAMA (1968)

<h3>To the Editor:—</h3> Dr. Skinner draws attention to an excellent point; we should pay a great deal more attention to our therapy to relieve our nurses. There are many drugs which are given several times during a day which would be quite effective if given once daily, some twice daily. It is most important to look into ways of saving nursing time without in any way jeopardizing patient care. In fact, as Dr. Skinner points out, patient care may be improved, as by an uninterrupted night's rest. However, one cannot generalize across the board. One should look into each drug, its method of action, its duration of action, and the patient's particular disease before he makes any rule about that one individual drug. It would be easier if generalization could be made, but a careful group of interested physicians knowledgeable of drugs should look carefully into the rules in the
FEDERALIZED MEDICAL TREATMENT VERSUS THE PRIVATE PRACTITIONER
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Growth-promoting effects of insulin-like growth factor-1 (IGF-1) on hematopoietic cells: overexpression of introduced IGF-1 receptor abrogates interleukin-3 dependency of murine factor-dependent cells by a ligand-dependent mechanism
Authors: JA McCubrey, LS Steelman, MW Mayo, PA Algate, RA Dellow, M Kaleko
Journal: Blood (1991)
The Discogram
Authors: Z. E. Taheri
Journal: JAMA (1964)

<h3>To the Editor:—</h3> I question Dr. Holt's ability to interpret the discogram. Figure 2, page 800, shows essentially normal disks without evidence of degeneration. The lateral view shows perfectly normal nucleus pulposus. Since this x-ray was selected for publication, I presume that it was, in his judgment, the x-ray that showed the severest degree of abnormality. I have made over 1,000 discograms in the lumbar and cervical areas and am unequivocally convinced that cervical discography is one of the greatest diagnostic tests in the hands of properly trained neurosurgeons for the diagnosis of intervertebral disk disorders.
Family and community.
Journal: BMJ (1966)

MSBH 1089 be tender to palpation, with limitation of movement.There are sometimes also objective changes in the hand, with red- ness, swelling, and stiffness, which may end in atrophy of the small muscles.These " frozen shoulder" and " shoulder- hand " syndromes may develop at any time within a year of the attack and are of importance, since it has been estimated' 6 that over 10% of patients have some degree of disability in shoulder or hand after myocardial infarction.
THE FOREIGN CULT IN AMERICAN MEDICINE.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PLAIN SPEAKING ON SANITARY MATTERS
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 214: Outcomes of KD by the KD type: Linking Inpatient and Outpatient Follow-up Data
Authors: Karen Texter, John Kovalchin, Octavio Ramilo, Preeti Jaggi
Journal: Circulation (2015)

Background: The relationship between KD type and outcomes is not well described. We sought to describe the incidence of KD outcomes based on type of KD presentation. Methods: Using an electronic medical record, we prospectively recorded clinical data for each KD encounter (initial treatment, 2 and 6 week follow up visits) for all pts treated with IVIG at our hospital and followed in our KD clinic from 11/2012-9/2014. Pts were grouped by KD type as determined on the day of treatment - Complete, Incomplete, or questionable KD (qKD), defined as incomplete KD and &lt; 3 supplemental lab criteria. Late treatment was defined as IVIG given at &gt; 10 days of fever. The correlation of KD type with outcomes of persistent fever requiring repeat IVIG, development of periungual peeling (PP), and coronary abnormalities (CAA) was assessed using chi-square. Results: We studied 109 pts treated with IVIG; 95 were treated within 10 days of fever onset (14 late). Late treatment was most common in qKD (9/19=47%) compared to Incomplete (4/22=18%) and Complete (1/68=1.5%), p&lt;0.01. PP was least common in qKD (4/19=21%), compared to Incomplete (12/22=54%) and Complete (49/68=72%), p&lt;0.05. No pts with qKD developed CAA, compared to 5/67 (7%) of Complete and 3/18 (16%) of Incomplete pts treated within 10 days of fever, (p=0.16, NS). Late treatment more commonly had CAA (5/14=36%, v. 8/95=8%), relative risk = 4.2 (p=0.003). In pts with CAA, 10 /13 (77%) had CAA on the first echocardiogram. The remaining 3 pts (2 Complete, 1 Incomplete) had a pericardial effusion initially and developed CAA by the second echocardiogram. Need for repeat IVIG was not different between groups (Complete 16/68 = 24%, Incomplete 3/22=14%, qKD 2/19=11%, p=0.33). Of the 2 qKD pts who required a second dose of IVIG, one was subsequently diagnosed with juvenile idiopathic arthritis and the other with Bartonella henselae; neither developed PP or CAA. Conclusions: The incidence of CAA was not statistically different between KD types, though no qKD pts developed CAA despite a higher incidence of late treatment with IVIG. In most pts who developed CAA, the initial echocardiogram showed either CAA or a pericardial effusion. PP was least common in qKD. In qKD, failure of initial IVIG should prompt re-evaluation of the diagnosis of KD.