tbuckley/cabot-search huggingface dataset:
Residual tumor resection (RTR) in advanced testicular cancer: Indication, outcome and prediction of histology
Authors: M. Seger, M. Roessler, J. Beyer, A. Heidenreich
Journal: Journal of Clinical Oncology (2004)

4645 Background: RTR following inductive chemotherapy for advanced testicular cancer is an essential part of the interdisciplinary multimodality treatment. Since RTR is a challenging surgical procedure, aim of our study was to develop a clinically reliable model for identification of a low risk group in which RTR could be safely omitted. Methods: RTR was performed in 85 pts after first-line chemotherapy with all pts showing normalized tumor markers. In a retrospective analysis > 15 pre-RTR parameters including immunohistochemical expression of mdr-1 in the orchiectomy specimens were assessed to predict necrosis/fibrosis or teratoma in residual tumors. Statistical analysis was performed by uni- and multivariate analysis, parameters were statistically significant if p<0.05. Results: 56 pts (67.5%) had necrosis/fibrosis, 17 (20.5%) and 10 pts (12%) had mature teratoma and vital cancer in the RTR specimens, resp. After multivariate analysis only pre-chemotherapeutic AFP levels and tumor size before RTR were independent predictors of necrosis. However, positive predictive values were only 74% and 76%, resp., sensitivity was 81% and 52.8%, resp., specificity was 59% and 79.3%, resp. Of pts with <2cm residual masses 6 had vital cancer /mature teratoma, of pts with < 15ng/ml AFP 9 had vital cancer/mature teratoma. Mature teratoma in the orchiectomy specimen was associated with a 86% risk for teratoma in the residual mass whereas non-teratomatous components in the primary cancer had a 47% risk to harbour teratoma in the RTR specimen p<0.001). High mdr-1 expression in the orchiectomy specimen correlated with vital cancer/teratoma in the RTR specimen or with recurrences in pts with necrosis in the RTR specimen. Conclusions: Although pre-chemotherapy AFP levels < 15ng/ml and a residual mass < 2cm are associated with a favourable histology in the RTR specimen, an individual histology cannot be predicted. All pts with nonseminomatous germ cell tumors and residual masses need to undergo RTR. Mdr-1 expression in the orchiectomy specimen might turn out to be a valid clinical marker for unfavourable histology or early recurrences. No significant financial relationships to disclose.
Modified cardiac catheter for neonate and infant
Authors: J. Lynfield
Journal: JAMA (1966)

<h3>To the Editor:—</h3> Cardiac catheterization and selective angiocardiography carry an increased risk in the neonatal period and early infancy.<sup>1,2</sup>This communication reviews some of the problems associated with the use of cardiac catheters for diagnostic procedures, and describes a new modified pediatric NIH catheter designed to reduce the risks and increase the accuracy of those procedures in the neonate and small infant. Two principal types of catheter are in use for cardiac catheterization and angiocardiography. The first type, with an end hole, such as the Lehman catheter, has certain disadvantages for selective angiocardiography because of its tendency to recoil during injections. In addition, it is stiff and this increases the difficulties and dangers of intracardiac manipulation. Undesirable damping and difficulty with sampling may also occur with this catheter. The second type is the side-hole catheter which overcomes these difficulties and permits sampling and pressure recording as well as rapid
Abstract 19359: Local Injection of First Trimester Human Umbilical Cord Perivascular Cells (FTM-HUCPVCs) After Myocardial Infarction Increases Extracellular Matrix Processing Activity, Vascular Density and Blood Vessel Size Within the Infarct Scar
Authors: Peter Szaraz, Alexandra Lucato, Shu Hong Li, Jun Wu, Andree Gauthier-Fisher, Ren-Ke Li, Clifford L Librach
Journal: Circulation (2015)

Introduction: During myocardial infarction (MI) the ischemic heart muscle loses a substantial number of cells, and a poorly vascularised fibrotic scar forms. We previously showed that local injections of first trimester human umbilical cord perivascular cells (FTM-HUCPVCs) diminish scar tissue and significantly improve cardiac output after MI in rats. Hypothesis: We hypothesised that FTM-HUCPVCs induce superior tissue remodeling and revitalization post-MI by 1: elevating ECM processing gelatinase/collagenase activity, 2: increasing blood vessel penetration and revascularisation of the infarct scar. Methods: MI was induced by left ventricular coronary artery ligation on 8 week old Foxrnu rats. 1 week post-MI, FTM-HUCPVC, term HUCPVC or human BMSC (n=6 per group) were injected into the injured myocardium (3X106 cells each). Histology was performed 2 weeks after cell implantation. In situ gelatinase activity was assessed by fluorescent gelatinase substrate (DQ gelatin). Vascular density was assessed by endothelium-specific fluorescent isolectin (IB4). Fluorescent microscopy images were quantified for vascular density and blood vessel size by ImageJ (6 sections per heart, 9 random fields per section). Statistical analysis: ANOVA. Results: FTM-HUCPVC treatments resulted in increased fluorescent gelatine signal in the scar tissue of post-MI rat hearts (A) and displayed gelatinase activity in a structured pattern. Vascular density of the ischemic myocardium (B) was significantly higher (p&lt;0.01) in FTM- and term HUCPVC treated hearts compared to untreated (C). BMSC treatment did not result in significant improvement. Median area of blood vessel cross-sections was the highest after FTM-HUCPVC treatment and significantly higher (p&lt;0.01) than of BMSC treated hearts. Conclusion: FTM-HUCPVCs induce superior ECM processing and revascularisation in scar tissue after myocardial infarction compared with later gestation HUCPVCs and BMSCs.
Cervical Cancer Screening Among Women Without a Cervix—Reply
Authors: Brenda Sirovich, H. Gilbert Welch
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Moriz Kaposi
Authors: Arthur M. Ginzler
Journal: JAMA (1964)

<h3>To the Editor:—</h3> There was a surpriseing omission in the recent short biography and list of contributions to medicine of that extraordinarily perceptive dermatologist and clinician of the 19th century, Moriz Kaposi (<i>JAMA</i><b>187</b>:227 [Jan 18] 1964). Possibly the most outstanding of his many original contributions was his recognition and description—as a formidable systemic disease—of lupus erythematosus, which had previously been described as a localized dermatosis by Cazenave and Hebra (Kaposi, M.: Neue Beitrage zur Kenntnis des Lupus Erythematosus,<i>Arch Derm Syph</i><b>4</b>:36, 1872).
A lesson from Chinese medicine. The humanitarian imperative
Authors: R. Crawshaw
Journal: JAMA (1978)

THE OCCASION of our group's visit to the People's Republic of China grew out of the memory of Evans F. Carlson, a former Marine Corp general who garnered fame during World War II as the leader of Carlson's Raiders, an attack group that applied with devastating effects the tactics of the Chinese Communist guerrillas to Japanese defense positions. Carlson had spent considerable time in China during the 1930s studying the operations of the Eighth Route Army. He had earned their respect as an honest, open-minded man who was willing to learn under the most trying conditions. He eventually retired to Oregon, where he died in 1947. In his name our group of 22 was invited to China to increase understanding between two great peoples. <h3>A Blur of Impressions</h3> One of our hosts in Peking remarked that seeing China in three weeks was like studying flowers from a galloping horse. However,
Perivenular fibrosis as precursor lesion of cirrhosis
Authors: T. M. Worner
Journal: JAMA (1985)

Thirty-four male alcoholics underwent sequential liver biopsies as part of their evaluation. Of 19 subjects with simple fatty livers, only three showed progression of liver disease: one developed perivenular fibrosis after two years; a second showed no progression after three years, but developed perivenular fibrosis after four years; the third subject likewise showed no progression after one year, but developed incomplete cirrhosis after six years. In contrast, of 15 subjects with perivenular fibrosis at the time of the initial biopsy, 13 progressed to more severe stages of liver disease during a one- to four-year follow-up interval. Nine developed fibrosis, one developed incomplete cirrhosis and three developed cirrhosis. Thus, patients with perivenular fibrosis at the fatty liver stage are likely to progress to more severe stages of alcoholic liver disease if they continue to consume alcohol. (<i>JAMA</i>1985;254:627-630)
A CALL TO THE MEDICAL PROFESSION
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Annales Paediatriae Fenniae, Helsinki
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The relation of cytomegalovirus and Epstein-Barr virus antibodies to T-cell subsets in homosexually active men
Authors: R. Detels
Journal: JAMA (1984)

Eighty-nine homosexual men participated in a study of sexual practices, T-cell subsets, and antibody titers to cytomegalovirus (CMV) and Epstein-Barr virus (EBV). The prevalence of antibody to CMV was 96% and to EBV, 94%. Titers to CMV were higher in those practicing receptive anal intercourse. The CMV antibody titers were positively correlated with the T-helper/suppressor ratio, number of partners and venereal disease episodes, number of T-suppressor cells, and EBV titers. Twelve percent of the participants had a low ratio only, 18% T-suppressor augmentation, and 3% T-helper deficiency. The CMV titer and prevalence of receptive anal intercourse were higher in those with a low ratio only, T-suppressor augmentation, and T-helper deficiency. These results suggest that CMV infection is acquired through receptive anal intercourse and is associated with an increase in T-suppressor cells and, in some persons, a decrease in T-helper cells. (<i>JAMA</i>1984;251:1719-1722)
BMA criticises Government computer plans
Journal: BMJ (1980)

Familiarity with medicosocial legislation and its impact on his own organisation, the environment, and the population. SkilsThe ability to describe the state of health of a defined community and compare it with that of other communities.The ability to identify specific features in the physical, social, and psychological environment which endanger the health of the com- munity.How to assess the effectiveness ofthe medical services provided to prevent, cure, or alleviate illness and disability.How to assess the efficiency with which medical services are provided.The ability to collect, organise, and present, in an appropriate form, information relevant to his tasks.That he can prepare alternative plans for achieving realistic goals, identifying theS criteria which make for optimum use of available resources.
PERSPECTIVES IN MEDICAL LICENSURE
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Rensheng Shouwu Protects against Neuronal Injury by Inhibiting the Apoptosis Induced by Hypoxia and Reoxygenation
Authors: Zhu Jing, Wan Li, Zhu Yadong, Yang Xu, Cai Yongming, Bei Wei-Jian, Guo Jiao
Journal: Alzheimers Disease & Dementia (2016)

Rensheng Shouwu Capsule (RSSW) is an approved and patented drug of Traditional Chinese Medicine that has been used for years to treat vascular dementia and neural syndrome related to cerebral-vascular ischemia. However, the underlying mechanism of RSSW remains unclear.
Diagnosis of Legionnaires' disease
Authors: D. A. Johnson
Journal: JAMA (1984)

<h3>To the Editor.—</h3> We read with interest the recent review by Zuravleff et al.<sup>1</sup>There are four points we would like to add. Specimens with 25 or more typical rod forms by direct fluorescent antibody (DFA) test were reported as definitely positive, but in the study any number of typical organisms were included as positive. The Centers for Disease Control (CDC) criterion for a positive test is five or more typical fluorescent forms per smear, on all specimens with the exception of lung biopsy tissue, for which 25 or more organisms per smear are required (<i>Legionella</i>Direct Fluorescent Antibody Reagents, product brochure B77, 1982, Biologic Products Programs, Centers for Disease Control, Atlanta). One typical fluorescent form per smear has been suggested to be more sensitive and no less specific than the higher criterion.<sup>2</sup>In our conversation with personnel in the CDC legionnaires' disease testing laboratory, we learned
Clopidogrel and Long-term Outcomes After Drug-Eluting Stent Implantation
Authors: Fernando Alfonso
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ninth International Subcellular Methodology Forum
Journal: JNCI Journal of the National Cancer Institute (1984)

Journal Article Ninth International Subcellular Methodology Forum Get access JNCI: Journal of the National Cancer Institute, Volume 72, Issue 3, March 1984, Page 770, https://doi.org/10.1093/jnci/72.3.770-a Published: 01 March 1984
Seventeenth-century medical journalism. As exemplified by the Ephemerides Naturae Curiosorum
Authors: S. Jarcho
Journal: JAMA (1972)

The eminence and the long career of Dr. Morris Fishbein in medical journalism make it appropriate for an essayist who wishes to honor him to discuss an eminent and long-continued medical periodical, namely, the<i>Miscellanea Curiosa sive Ephemerides Medico-Physicae Germanicae</i>. This periodical was issued under the auspices of one of the earliest scientific societies, the Academia Naturae Curiosorum. The Academia is conveniently referred to as the Leopoldine Academy or the Leopoldina; the periodical is usually called the<i>Ephemerides</i>. It first appeared in 1670 and, with numerous changes of name, has continued to the present time. The following study is limited to its first year. Perhaps because medical periodicals were rare, the proceedings of 1670 were later reissued (1684), with typographical errors allegedly corrected, and a few illustrations added. I have used the printed text of the second edition, although the illustrations come from the first edition. The Academia Naturae Curiosorum
ADVANCED MEDICAL IGNORANCE
Journal: JAMA (1961)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
GERHARD VAN SWIETEN (1700-1772) BOERHAAVE'S BOSWELL
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Automobile child seating systems
Authors: W. F. Rowley
Journal: JAMA (1971)

<h3>To the Editor.—</h3> I would like to call your readers' attention to the effective date of the Motor Vehicle Safety Standard No. 213, Child Seating Systems, which is April 1, 1971 (<i>Fed Register</i><b>35:</b>14759-14821, 1970). This ruling provides that child seating systems offered for sale have to meet specifications set by the National Highway Traffic Safety Administration. Now, for the first time, a physician, who can and should recommend that parents of young children purchase restraining devices, can be assured that these devices will provide effective restraint. However, the safety seats will work<i>only if the instructions are followed</i>; these<i>always</i>include the use of a vehicle seat belt. Prior to this, many so-called child-car seats were not only inadequate, but at times were worse than nothing. The physician should inform parents that they should buy devices labelled as meeting the specifications which take effect April 1, 1971, or
A Comparison of Clofarabine-Based (GCLAC) and Cladribine-Based (CLAG) Salvage Chemotherapy for Relapsed/Refractory AML
Authors: Benyam Muluneh, Katie Buhlinger, Allison M. Deal, Joshua F. Zeidner, Matthew C. Foster, Katarzyna Joanna Jamieson, Jill Bates, Hendrik W. Van Deventer
Journal: Blood (2015)