tbuckley/cabot-search huggingface dataset:
New uncertainties in prenatal screening for neural tube defect.
Authors: R Harris, A P Read
Journal: BMJ (1981)

<h3>Background and objectives</h3> Documentation is important for quality improvement, education, and research. There is currently a lack of recommendations regarding key aspects of documentation in regional anesthesia. The aim of this study was to establish recommendations for documentation in regional anesthesia. <h3>Methods</h3> Following the formation of the executive committee and a directed literature review, a long list of potential documentation components was created. A modified Delphi process was then employed to achieve consensus amongst a group of international experts in regional anesthesia. This consisted of 2 rounds of anonymous electronic voting and a final virtual round table discussion with live polling on items not yet excluded or accepted from previous rounds. Progression or exclusion of potential components through the rounds was based on the achievement of strong consensus. Strong consensus was defined as ≥75% agreement and weak consensus as 50%–74% agreement. <h3>Results</h3> Seventy-seven collaborators participated in both rounds 1 and 2, while 50 collaborators took part in round 3. In total, experts voted on 83 items and achieved a strong consensus on 51 items, weak consensus on 3 and rejected 29. <h3>Conclusion</h3> By means of a modified Delphi process, we have established expert consensus on documentation in regional anesthesia.
ACACIA AND FUNDAMENTAL ASPECTS OF INTRAVENOUS INJECTIONS
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Staphylococcus aureus Carriage in the Nursing Home
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
European Perspectives
Authors: Peter Zartner
Journal: Circulation (2013)

received €10 000 from the German Foundation for Heart Research (see www.dshf.de) in 2012 to evaluate the use of pacemakers and defibrillators in paediatric patients with congenital heart diseases.Current use of pacemakers in infants and children has been adapted from techniques and material used for adults, but paediatric patients require different and individual strategies for in-and ex-plantation procedures, programming and tracing of the systems, adaptation to a variety of anatomical malformations, and coordination with interventional or surgical procedures.Paediatric restrictions and changes over time, such as vessel diameter and patient's growth, must be considered.The levels of evidence in the American Heart Association, American College of Cardiology, and Heart Rhythm Society guidelines for device-based therapy for patients with a congenital heart disease are C, with an increasing number of B, which reflects the necessity of an extended and comprehensive data analysis in this patient group.To address the lack of information, Dr Zartner's project aims to retrospectively analyse the use of electronic pacing systems in paediatric patients over the past 20 years in a multicentre setting.An internet-based, relational database
HIV Testing, Counseling, and Prophylaxis After Sexual Assault
Authors: Jean Flatley McGuire
Journal: JAMA (1994)

<h3>To the Editor.</h3> —The Working Group on HIV [human immunodeficiency virus] Testing, Counseling, and Prophylaxis After Sexual Assault<sup>1</sup>develops a case for preconviction "limited compulsory HIV testing" of sexual assault defendants to ameliorate the significant physical and mental health sequelae suffered by victims. The group justifies its considerable infringement of the accused's rights with three "compelling reasons": for the survivor, potential clinical and psychological benefits, and for the community, protection from further transmission. Unfortunately, the policy has a differential impact on communities of color and poor people: it supports problematic assumptions about the victims, it dismisses the public health goals of HIV testing and counseling activities, and it disregards the fact that HIV testing of the accused does not resolve the victim's prophylaxis and treatment dilemmas. The policy of testing preconvicted defendants would differentially affect poor African Americans and other minority men since they are most likely to be
TREES AND MALARIA.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Metformin plus a lifestyle intervention was more effective than either alone for antipsychotic-induced weight gain
Authors: Francisco J. Vaz-Leal
Journal: Annals of Internal Medicine (2008)

ACP Journal Club19 August 2008Metformin plus a lifestyle intervention was more effective than either alone for antipsychotic-induced weight gainFrancisco J. Vaz-Leal, MD, PhDFrancisco J. Vaz-Leal, MD, PhDUniversity of Extremadura Medical School and, University Hospital Network, Badajoz, Spain (F.J.V.)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-149-4-200808190-02005 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationWu RR, Zhao JP, Jin H, et al. Lifestyle intervention and metformin for treatment of antipsychotic-induced weight gain: a randomized controlled trial. JAMA. 2008;299:185-93. https://pubmed.ncbi.nlm.nih.gov/18182600Clinical Impact RatingsGIM/FP/GP: Mental Health: Endocrinology: Reference1 Shiloh R, Weizman A, Stryjer R, Nutt D. Atlas of Psychiatric Pharmacotherapy. 2nd edition. Abingdon, UK: Taylor & Francis; 2006. Google Scholar Author, Article, and Disclosure InformationAuthors: Francisco J. Vaz-Leal, MD, PhDAffiliations: University of Extremadura Medical School and, University Hospital Network, Badajoz, Spain (F.J.V.)This article was published at Annals.org on 5 August 2008. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 19 August 2008Volume 149, Issue 4Page: JC2-5KeywordsAntipsychoticsBody mass indexExerciseInsulinInsulin resistancePatientsSafetySchizophreniaSubstance abuseWeight gain ePublished: 19 August 2008 Issue Published: 19 August 2008 Copyright & PermissionsCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Urate spherulites in gouty synovia
Authors: J. J. Fiechtner
Journal: JAMA (1981)

We have identified urate crystals in gouty synovial fluid in a spherulite form. Studies in vitro established these "beachball" structures as chemically identical to classic "needles" of monosodium urate monohydrate, the prime factor in gouty arthritis. Previously described in the 1890s by a German scientist, these structures have not been recognized by clinicians examining fluid from arthritic joints. We suggest an identification scheme for "beachball-like" structures in synovial fluid. (<i>JAMA</i>1981;245:1533-1536)
SAT0575 Disease Activity in Psoriatic Arthritis (PSA): Defining Remission and Treatment Success Using the Dapsa-Score
Authors: M. Schoels, D. Aletaha, F. Alasti, H. Haslacher, J. Smolen
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> The Disease Activity Index for Psoriatic Arthritis (DAPSA) is a valid, responsive and discriminative tool. Definitions of disease activity states and therapeutic response are still missing. <h3>Objectives</h3> To derive such criteria for the DAPSA instrument. <h3>Methods</h3> We retrieved 30 patient profiles from an observational database including joint counts, patient pain and global activity ratings, and C-reactive protein levels and carried out a survey among experts to classify patients into remission (REM); low (LDA), moderate (MDA), or high (HDA) disease activity. Based on each state9s 25th and 75th percentiles of DAPSA values, we defined upper and lower thresholds. To define minor, moderate and major treatment response, we used Cohen9s Kappa statistics and analysed agreement of DAPSA percent change with ACR20/50/70-response in three randomized controlled trials. <h3>Results</h3> Our survey yielded a response rate of 75%. Mean DAPSA differed significantly between patients classified as REM, LDA, MDA, or HDA (p&lt;0.001). Based on the respective DAPSA quartiles, we propose cut-off values of ≤4 for REM, &gt;4 and ≤14 for LDA, &gt;14 and ≤28 for MDA, and &gt;28 for HDA. We observed best agreement of DAPSA with ACR20/50/70 response at DAPSA changes of 50/75/85% for minor, moderate and major improvement, respectively (Figure). Cross-validation strongly supported these results. <h3>Conclusions</h3> The DAPSA constitutes a disease-specific, validated, and feasible tool for PsA assessment. In this study, we provide criteria for disease activity states and for treatment response. They are based on an international expert survey, and are supported by good performance in clinical trials and observational data alike. <h3>Disclosure of Interest</h3> None declared
Metabolism and Toxicity of Hydrochlorofluorocarbons: Current Knowledge and Needs for the Future
Authors: M. W. Anders
Journal: Environmental Health Perspectives (1991)

Hydrochlorofluorocarbons (HCFCs) are being developed as replacements for chlorofluorocarbons (CFCs) that deplete stratospheric ozone. The depletion of stratospheric ozone may increase the intensity of ultraviolet radiation at the earth's surface, which may be associated with global, adverse human health effects. The greater tropospheric lability of HCFCs, which is due to the presence of C-H bonds, reduces HCFC migration to the stratosphere; HCFCs should, therefore, cause less depletion of stratospheric ozone than CFCs. HCFCs under development include HCFC-22 (chlorodifluoromethane), HCFC-123 (2,2-dichloro-1,1,1-trifluoroethane), HCFC-132b (1,2-dichloro-1,1-difluoroethane), HCFC-134a (1,1,1,2-tetrafluoroethane), HCFC-141b (1,1-dichloro-1-fluoroethane, and HCFC-142b (1-chloro-1,1-difluoroethane). With the exception of HCFC-22, which is already in use, the metabolism and toxicity of HCFCs have not been studied in detail. By analogy to chlorinated ethanes, predictions can be made about the possible metabolism of HCFCs, but there are insufficient data available to predict rates of metabolism. Although most HCFCs appear to show low acute toxicity, some HCFCs are mutagenic in the Ames test. Hence, future research on HCFCs should include studies on the in vivo and in vitro metabolism of HCFCs as well as on their toxicity in in vivo and in vitro systems.
Bromide intoxication secondary to pyridostigmine bromide therapy
Authors: D. M. Rothenberg
Journal: JAMA (1990)

The diagnosis of bromide intoxication is often aided by the detection of a low or negative anion gap due to the laboratory detection of bromide as chloride. A 59-year-old woman with myasthenia gravis who received a large dose of pyridostigmine bromide developed postoperative psychosis and was diagnosed as having bromide intoxication. The diagnosis was suspected in the setting of a negative anion gap and only later confirmed by direct measurement of the serum bromide level. To our knowledge, this is the first reported case of bromide intoxication due to pyridostigmine bromide administration. (<i>JAMA</i>. 1990;263:1121-1122)
Abstract LB-258: EGFR and c-MET cooperate to enhance PARP inhibitor resistance in hepatocellular carcinoma
Authors: Qiongzhu Dong, Yi Du, Xixi Zhao, Hui Li, Chunxiao Liu, Yongkun Wei, Mien-chie Hung
Journal: Cancer Research (2019)

Abstract Poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors are currently used in the clinic for the treatment of ovarian and breast cancers. However, the therapeutic efficacy of PARP inhibitor (PARPi) in the clinical trial for hepatocellular carcinoma (HCC) has been disappointing. To ensure therapeutic efficacy of PARPi against HCC, a disease often diagnosed at intermediate to advanced stages with no effective treatment options, it is critical to identify not only biomarkers to predict PARPi resistance but also rational combination treatments to overcome this. Here, we demonstrate that EGFR forms a heterodimer with c-MET, and the complex interacts with and phosphorylates Y907 PARP1 in the nucleus contributing to PARPi resistance. Inhibition of both EGFR and c-MET sensitizes HCC cells to PARPi. Combination of EGFRi, METi and PARPi significantly inhibited tumor growth in HCC animal model. Both EGFR and c-MET are known to be overexpressed in HCC. The current report provides a rationale to explain why PARPi does not work in clinical trials for HCC and also suggests an effective combination treatment consisting of EGFR, c-Met, and PARP inhibitors for HCC. Note: This abstract was not presented at the meeting. Citation Format: Qiongzhu Dong, Yi Du, Xixi Zhao, Hui Li, Chunxiao Liu, Yongkun Wei, Mien-chie Hung. EGFR and c-MET cooperate to enhance PARP inhibitor resistance in hepatocellular carcinoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr LB-258.
2007 James B. Herrick Award and Lecture—The Road Ahead
Authors: David Holmes
Journal: Circulation (2007)

The road ahead always starts from where it began. For the field of interventional cardiology, the road began 30 years ago this past September, when a 38-year-old physician treated a 38-year-old man for symptomatic coronary artery disease. After this “disruptive” experience, using “disruptive” technology, by a “disruptive” young physician, the landscape has never been the same. Andreas Gruentzig, that physician, revolutionized the practice of modern cardiovascular care, not just with the introduction of percutaneous transluminal coronary angioplasty, but even more with the concept that a person could work safely in an awake patient within a vascular tree to achieve a specific goal. This sentinel event spurred the development of an extensive family tree of discipline, including intravascular ultrasound; angioscopy; percutaneous treatment of structural heart disease, including among others valvular heart disease, hypertrophic obstructive cardiomyopathy, and atrial fibrillation; ablation; and treatment of carotid and peripheral arterial disease and, more recently, stroke. In addition, Dr Gruentzig can be said to have encouraged the development of less invasive surgical revascularization approaches, such as “mid-cab” coronary bypass graft surgery. Now that we have broken the barrier of working therapeutically within the vascular tree, the road ahead will include continual assignments and miniaturization of techniques for identification, prevention, and treatment of disease. That road ahead will only be limited by our ability to imagine and create and then our ability to document improved outcome for society, in both individuals and as a whole.
Maternal or Infant Antiretroviral Drugs to Reduce HIV-1 Transmission
Journal: New England Journal of Medicine (2010)

Background-We evaluated the efficacy of a maternal triple-drug antiretroviral regimen or infant nevirapine prophylaxis for 28 weeks during breast-feeding to reduce postnatal transmission of human immunodeficiency virus type 1 (HIV-1) in Malawi.Methods-We randomly assigned 2369 HIV-1-positive, breast-feeding mothers with a CD4+ lymphocyte count of at least 250 cells per cubic millimeter and their infants to receive a maternal antiretroviral regimen, infant nevirapine, or no extended postnatal antiretroviral regimen (control group).All mothers and infants received perinatal prophylaxis with single-dose nevirapine and 1 week of zidovudine plus lamivudine.We used the Kaplan-Meier method to estimate the cumulative risk of HIV-1 transmission or death by 28 weeks among infants who were HIV-1negative 2 weeks after birth.Rates were compared with the use of the log-rank test.Results-Among mother-infant pairs, 5.0% of infants were HIV-1-positive at 2 weeks of life.The estimated risk of HIV-1 transmission between 2 and 28 weeks was higher in the control group (5.7%) than in either the maternal-regimen group (2.9%, P = 0.009) or the infant-regimen group (1.7%, P<0.001).The estimated risk of infant HIV-1 infection or death between 2 and 28 weeks was 7.0% in the control group, 4.1% in the maternal-regimen group (P = 0.02), and 2.6% in the infant-regimen group (P<0.001).The proportion of women with neutropenia was higher among those receiving the antiretroviral regimen (6.2%) than among those in either the nevirapine group (2.6%) or the control group (2.3%).Among infants receiving nevirapine, 1.9% had a hypersensitivity reaction.
Heal Thyself
Authors: David L. Freeman
Journal: Annals of Internal Medicine (1991)

On Being a Doctor15 April 1991Heal ThyselfDavid L. FreemanDavid L. FreemanSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-114-8-694 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFor the physician, the greatest lessons may be found in personal illness. The fear of a steady chest pain, the disability of musculoskeletal injury, even the discomfort of a short-lived infection all may bring to the doctor new insights into the illnesses of his or her patients. But what of major depression? Can anything more than tragic impairment result from that experience?Two days after a routine hysterectomy, my beloved wife developed fever, abdominal pain, shock, obtundation, and cardiac arrest. Resuscitated, she endured five major abdominal procedures and, over 6 long weeks, remained barely alive with ventilator therapy, dialysis, pressor... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByZieke dokters anno 1998huisarts onderzoekWhen Physicians Treat Members of Their Own Families 15 April 1991Volume 114, Issue 8Page: 694-694KeywordsDisabilitiesFearFeversHeartHysterectomyIschemiaMedical dialysisMusculoskeletal injuryShockVentilators Issue Published: 15 April 1991 Copyright©1991 American College of PhysiciansPDF DownloadLoading ...
Beyond eclecticism
Authors: E M Abroms
Journal: American Journal of Psychiatry (1983)

Biopsychosocial eclecticism is incomplete because it does not address the important issues of differential causation and treatment staging. Psychiatric serialism goes beyond eclecticism to consider biological, psychosocial, and existential-moral parameters as equipotential and hierarchical. What this means in practice is that, after forming a treatment alliance, the therapist must always assess the evidence for a biological substrate of disorder and, where feasible, administer the appropriate biological treatments. On a stable biological platform, psychosocial interventions can then be utilized to promote the goals of lieben and arbeiten, and an existential therapy relationship can be forged to promote personal integrity.
Aspirin
Authors: Sanjit Bagchi
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal