tbuckley/cabot-search huggingface dataset:
Fatalities Associated With Large Round Hay Bales—Minnesota, 1994-1996
Journal: JAMA (1998)

Agriculture has one of the highest occupational fatality rates of all U.S. industries. Since the mid-1970s, traditional small-bale balers have gradually been replaced by large-bale balers in the agriculture industry. Expanded use of these balers has resulted in worker exposure to new hazards not present during handling of traditional small bales; the larger size of the bales increases the potential for serious injury or death while workers handle them. During 1994-1996, seven persons in Minnesota died in separate incidents that involved large round hay bales (i.e., cylindrical bales approximately 5 feet in length with flat ends, diameters of approximately 6 feet, and weights ranging from 750 to 1500 lbs). The Minnesota Fatality Assessment and Control Evaluation program (MN FACE), a program sponsored by CDC's National Institute for Occupational Safety and Health (NIOSH), was notified of these incidents by the Minnesota Extension Service, a newspaper clipping service, and/or by death-certificate review. This report describes three incidents that were reported to MN FACE during 1994-1996, summarizes national surveillance for bale-associated deaths during 1980-1995, and provides recommendations to prevent fatalities associated with large bales.
New laws on landfills.
Authors: Ronald Estabrook
Journal: Environmental Health Perspectives (1996)

Forum case will set a precedent for other local gov- ernments to enforce sewage deanup. Carcinogens in FoodLabeled a "finding sure to appeal to anyone tired of washing vegetables in detergent to remove pesticides" by a New York Times health columnist, the National Academy of Sciences National Research Council's February report, Carcinogens and Anticarcinogens in the Human Diet, found little to be alarmed about concerning links between chemicals in food and cancer."I've really been surprised at the great interest that has resulted from the study, and from the message that if you use common sense when you eat, you're alright," says
Abstract 563: A biparatopic agonist antibody for OX40 that exhibits superior activity without secondary crosslinking
Authors: Bonnie Hammer, Mandar Bawadekar, Matthew Bissen, John Painter, Lauren Lehmann, Francis Qufei Li, Lucas Bailey, Bryan Glaser, Roland Green
Journal: Cancer Research (2019)

Abstract The development of agonistic antibodies that activate T-cell co-stimulatory pathways represents a therapeutic strategy with significant clinical potential. However, challenges remain for the translation from in vitro efficacy to clinical success. OX40 and other tumor necrosis factor receptor (TNFR) superfamily members are notorious for requiring high-order receptor clustering in order to achieve full activity. For monoclonal antibodies, this high-order clustering is generally achieved through secondary cross-linking strategies. In vivo, this secondary cross-linking is often supplied through internal immune effector cells via Fc engagement. Bispecific and biparatopic antibodies represent an emerging class of drug molecules that enable unique mechanisms of action relative to their monoclonal counterparts. Here, we describe the use of our bispecific platform for the generation of large panels of biparatopic antibodies which enabled high-throughput screening for the discovery of an array of OX40 agonistic molecules. We have optimized these multivalent antibodies that exceed the potency of the OX40 ligand in NFkB activation without the need for secondary cross-linking. These agonist antibodies have additionally been characterized using primary T cell assays to monitor the kinetics of growth proliferation and cytokine secretion, outperforming cross-linked antibodies currently being tested in clinical trials. In co-culture systems, these agonist antibodies were effective in inhibiting immuno-suppressive properties of Tregs. Our lead OX40 agonist antibody has been optimized for activity and developability and has entered stable cell line development to further support pre-clinical activities. Citation Format: Bonnie Hammer, Mandar Bawadekar, Matthew Bissen, John Painter, Lauren Lehmann, Francis Qufei Li, Lucas Bailey, Bryan Glaser, Roland Green. A biparatopic agonist antibody for OX40 that exhibits superior activity without secondary crosslinking [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 563.
Neurology
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pulmonary emphysema
Authors: D C S Hutchison
Journal: BMJ (1994)

severity of symptoms and increase near term.Close moni- toring of fetal wellbeing is essential, although no single test reliably predicts the risk of intrauterine death.Raised serum concentrations of maternal bile acids correlate with the severity of pruritus and risk of fetal distress.10Some obstetricians recommend regular non-stress and con- traction stress tests.Delivery should ideally take place around 38 weeks after serial estimations of fetal lung maturity and maternal serum concentrations of total bile acids.Delivery around 36 weeks should be considered for severe intrahepatic cholestasis of pregnancy with jaundice and progressive increases in serum bile acid concentrations if fetal distress is suspected and lung maturity has been confirmed.'9The intrapartum fetal heart rate seems an unreliable indicator of fetal distress in intrahepatic cholestasis of pregnancy.9Giving vitamin K, to the baby immediately after birth may help prevent intracranial bleeding.Recent reports of optimistic fetal outcomes are mostly from experienced referral centres in countries with a high prevalence of the condition.' 9Maternal and fetal wellbeing are likely to improve with a better understanding of the pathogenetic mechanisms associated with bile acid metabolism, pruritus, and cholestasis.Treatment will be hampered by insufficient data on drug toxicity during late pregnancy in humans.
HPV in upper aerodigestive tract tumors in southern Brazil.
Authors: Luis Carlos Moreira Antunes, Leandro Bizarro Muller, Antonio de Barros Lopes, Renato Borges Fagundes
Journal: Journal of Clinical Oncology (2013)

47 Background: The highest rates of esophageal cancer in Brazil occur in Rio Grande do Sul (18/100,000/year for men), where squamous cell carcinoma is the most common. Furthermore, the incidence of head and neck squamous cell carcinoma (HNSCC) is significant in this region (11/100,000/year for cancer of the oral cavity and 10/100,000/year for laryngeal cancer in men). Tobacco smoking and alcohol consumption are the major risk factors for esophageal squamous cell carcinoma (ESCC) and HNSCC. The role of HPV in the development of ESCC remains controversial. Otherwise, there are some evidence that HPV-related HNSCC is a distinct entity compared with HNSCC associated with smoking and alcohol consumption. Methods: Polymerase chain reaction (PCR) was used to evaluate the presence of Human Papillomavirus from 218 samples from three groups of patients. Group 1 comprised 51 patients with ESCC who underwent esophagectomy, in which two samples from each patient were analyzed: one sample of the tumor and another of normal esophageal mucosa distant from the tumor. Group 2 comprised 37 patients with HNSCC who underwent Lugol chromoendoscopy. In this group, samples were analyzed from the primary tumor, the stained areas of mucosa from the middle esophagus, and, when present, discolored and tumoral areas of the esophageal mucosa. Thirty-seven dyspeptic patients, not exposed to smoking or alcohol consumption, comprised Group 3, in which one sample per patient of mucosa with normal appearance from the middle esophagus was evaluated. Nested-PCR with MY09/11 and GP5/6 L1 primers was used to detect HPV L1 in samples fixed in formalin and stored in paraffin blocks. Results: Of a total of 224 samples fixed in formalin and stored in paraffin, only 6 samples had insufficient material for PCR analysis: one sample from normal distal epithelium in Group 1, one sample from a stained area and 2 samples from unstained areas in Group 2 and two samples from normal esophageal mucosa in Group 3. PCR was positive for one of conserved genes GAPDH, G3PDH or B-globin and negative for HPV DNA in all the 118 samples tested. Conclusions: There is no evidence that HPV is involved in carcinogenesis of the upper aerodigestive tract in southern Brazil.
Cigarette smoking as a risk factor for stroke. The Framingham Study
Authors: P. A. Wolf
Journal: JAMA (1988)

The impact of cigarette smoking on stroke incidence was assessed in the Framingham Heart Study cohort of 4255 men and women who were aged 36 to 68 years and free of stroke and transient ischemic attacks. During 26 years of follow-up, 459 strokes occurred. Regardless of smoking status and in each sex, hypertensive subjects had twice the incidence of stroke. Using the Cox proportional hazard regression method, smoking was significantly related to stroke after age and hypertension were taken into account. Even after pertinent cardiovascular disease risk factors were added to the Cox model, cigarette smoking continued to make a significant independent contribution to the risk of stroke generally and brain infarction specifically. The risk of stroke increased as the number of cigarettes smoked increased. The relative risk of stroke in heavy smokers (&gt;40 cigarettes per day) was twice that of light smokers (fewer than ten cigarettes per day). Lapsed smokers developed stroke at the same level as nonsmokers soon after stopping. Stroke risk decreased significantly by two years and was at the level of nonsmokers by five years after cessation of cigarette smoking. (<i>JAMA</i>1988;259:1025-1029)
Ophthalmology
Authors: Terrence P. O'Brien
Journal: JAMA (1992)

It is fitting as ophthalmology celebrates the 75th anniversary of the American Board of Ophthalmology,<sup>1</sup>the first medical subspecialty examining board in the world, that ophthalmologists continue to make important scientific contributions not only to preserve vision, but also to decrease mortality from associated systemic diseases. The acquired immunodeficiency syndrome (AIDS) epidemic advances at alarming rates, and ophthalmologists are increasingly involved in providing care to its victims. Indeed, cytomegalovirus (CMV) retinitis is the most frequent opportunistic ocular infection in patients with AIDS,<sup>2</sup>with 20% developing retinitis due to CMV at some time in their lives.<sup>3</sup>If untreated, CMV retinitis ultimately results in blindness. Currently, two drugs are approved for treatment of CMV retinitis: ganciclovir (Cytovene, Syntex Laboratories, Inc, Palo Alto, Calif) and foscarnet (Foscavir, Astra Pharmaceutical Products Inc, Westborough, Mass). Both antiviral agents must be administered initially at high doses for induction therapy, followed by lifelong maintenance
Viral hepatitis associated with illicit parenteral use of drugs
Authors: W. E. Dismukes
Journal: JAMA (1968)

Hepatitis surveillance case records of persons aged 15 to 29 years, with the dates of onset of disease during a 45-month period were cross-checked against state and municipal files of arrested drug-law violators. One hundred and eighty-three persons with hepatitis were known to use drugs parenterally and an additional 79 were suspected parenteral-drug users. Of these 262 persons with hepatitis associated with parenteral use of drugs, 92% were males. The 262 cases represent 16.6% of all cases of viral hepatitis in the 15- to 29-year-old age group in New Jersey. The data indicate that illicit parenteral use of drugs accounts in large part for the unusually high incidence of hepatitis among young adult males in New Jersey and contributes significantly to hepatitis morbidity.
Kidney biopsies in control or cyclosporin Atreated psoriatic patients.
Journal: British Journal of Dermatology (1990)

Kidney biopsies were obtained from 14 adult patients treated with cyclosporin A (CyA) for psoriasis. These biopsies were compared with those from 16 psoriatic patients of the same age, but who were not receiving treatment with CyA. Patients receiving CyA had a maximum mean dose of 5.1 mg/kg/day for a mean duration of 15 months (range 3–37 months). Minimal or slight interstitial fibrosis, tubular atrophy or arteriolopathy were seen in the biopsies of patients receiving CyA as well as in those of the controls. No relevant CyA‐related structural alterations of the kidney were detected.
Correction
Authors: Hirsutism St, Kent West, Societv Medico-Chirurgical, Max Rosenheim, T Hunt, L Marun, E Bywaters, H Wallace, R Bayliss, C Newman, K Robson, R Pearson, A Whitfield, J Badenoch, J Waterlow As Charles, F Hart, Philip Ellman
Journal: BMJ (1967)
Neurosciences Research
Authors: Frederic T. Jung
Journal: JAMA (1969)

This is the first volume of a serial publication planned to deal with the most recent advances in research on normal and abnormal neural activity. It is the work of 14 contributors, whose shares vary widely in length, character, and unfortunately also in intelligibility. The earlier chapters describe basic experiments on the subcellular details of neurone physiology; the extraordinarily fine techniques used in this field can measure enzyme activity in samples of cytoplasmic or nuclear material with volumes less than a micromicroliter. Subsequent chapters deal with neural phenomena on a larger scale, such as the nervous control of muscular activity, the processes of learning and use of knowledge, and the application of high-speed methods of observation to problems of head injury. For readers unfamiliar with this field of research, there is likely to be difficulty with abbreviations such as pg and nl (for picograms and nanoliters), TCA cycle, BuCHE, and
Council on drugs. To label or not to label
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
OP06 * METABOLOMIC ANALYSIS OF GLIOBLASTOMA MULTIFORME UPON ARGININE DEPRIVATION TREATMENT
Authors: J. K. Langer, E. C. Y. Chan, H. Antti, E. Want, K. ONeill, N. Syed
Journal: Neuro-Oncology (2014)

INTRODUCTION: Treatment of glioblastoma (GBM) remains challenging, and metabolic targeting opens novel treatment approaches. Arginine plays a central role in various proliferative cellular reactions, and argininosuccinate synthetase-1 (ASS1) is the rate-limiting enzyme of arginine synthesis. Methylation specific silencing of ASS1 exerts an auxotrophic dependency for extracellular arginine in GBM. We have identified that ASS1-silenced GBM cell lines targeted by arginine-deprivation therapy (ADI-PEG20) resulted in arrested proliferation, highlighting the key role of arginine in GBM cell proliferation. Consequences of arginine deprivation were analysed by metabolomics, with the aim of identifying novel metabolic targets for therapy. METHOD: ASS1 positive and negative GBM cell lines were exposed to ADI-PEG20, and samples for NMR and GC/MS analysis were prepared, and processed according to established protocols. Data was analysed by principal component analysis (PCA) using SIMCA-P software, and further multi- and uni-variate studies were performed in MATLAB. RESULTS: NMR and GC/MS analysis, via PCA, revealed separation in the metabolic profiles between ADI-PEG20 treated and non-treated GBM cell lines, particularly striking in ASS1-deficient cell lines. OPLS-DA analysis of NMR data highlighted metabolites, such as creatine. We have also identified a significant decrease in choline levels, not previously been linked to arginine deprivation. CONCLUSION: We have identified differentially altered metabolic pathways in GBM as a result of arginine deprivation, that are involved in proliferation. Changes observed in GBM lines showed potential to use metabolic profiles for monitoring treatment response, and open new avenues for therapies.
New York Court Upholds Work-Hour Limits
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CHAIRMAN'S ADDRESS.
Authors: A. RAVOGLI
Journal: JAMA (1898)

It is extremely grateful to me on this happy and memorable occasion of the fiftieth anniversary of this great NationalAssociation, to have the honor of welcoming you to the City of Philadelphia as Chairman of this Section. This great city where the bell rang the first time for the freedom and the independence of the United States, has been the birthplace of theAmerican Medical Association, one of the largest and most powerful medical organizations in existence. To recall to you the beginning of thisAssociation, its motives and its scope would be out of place, I will therefore limit myself to a few points of history concerning our special Section. In 1869, at the annual meeting the assembly adopted a resolution which recognized specialties as a proper and legitimate field of practice. From that time several sections of medical branches were established, no one, however, showed the necessity
Abstract 24: Childhood Risk Factor Patterns Predict Adult Type 2 Diabetes Better Than Single Childhood Risk Factor Measures: The International Childhood Cardiovascular Cohort (i3C) Consortium
Authors: Tian Hu, Alan Sinaiko, Elaine Urbina, Olli Raitakari, Jessica Woo, Lydia Bazzano, Julia Steinberger, Trudy Burns, Markus Juonala, Alison Venn, Stephen Daniels, Ronald Prineas, Terence Dwyer, Costan Magnussen, David Jacobs
Journal: Circulation (2017)

Background: Childhood risk factors predict adult onset type 2 diabetes mellitus (T2DM). We developed a novel statistical approach using risk factor patterns to improve prediction. Methods: The cohort included 5269 individuals from the Bogalusa Heart Study, Cardiovascular Risk in Young Finns Study, Childhood Determinants of Adult Health Study, Childhood Cohort Studies in Minneapolis and Cincinnati, and the Muscatine Study. All had 2+ childhood measures of risk factors between ages 3 and 20 in 1970s-90s and reported whether they had T2DM between ages 21 and 63 in 2011-16. We established sex-specific polynomial age patterns to represent standard growth curves for each risk factor and computed the residual from this standard for each observation within ages 3-20. Residuals were regressed on age within each person to get a personal intercept and slope, and then 9 patterns were formed as intercept tertiles crossed with slope tertiles within each intercept tertile. T2DM associations with risk factors were assessed by using either the first childhood measurement or childhood patterns of body mass index (BMI), systolic blood pressure (SBP), and height (HT), with covariates age at first visit, sex, race, and study. Results: Mean age at first measure was 9.2 (SD 3.3) y, 41% male, 85% white, 12% black, with 2-19 repeats of childhood risk factor measures. Risk factor patterns tended to diverge from each other by mid-childhood and measured adult risk factor values were well predicted, diverging widely across the childhood patterns (not shown). After mean follow-up of 29.0 (SD 8.1) y, 282 (5.4%) participants self-reported T2DM. T2DM was predicted by the model including first measures of BMI (positive), SBP (positive), and HT (inverse), but the corresponding pattern model improved prediction probability by 55% (Table). Conclusion: These findings show the value of using multiple risk factor measurements during childhood and the potential for developing risk factor pattern charts to be used as clinical standards for predicting adult T2DM risk.
CORRIGENDUM
Journal: American Journal of Hematology (2021)

In the original article, under the discussion section, the below sentence was incorrectly mentioned as "The rates had also improved from 33% to 59% for adults 20 to 29 years old, 24% to 59% for adults 30 to 39 years old, and 14% to 43% for those 14% to 43% between the same time periods.",while