tbuckley/cabot-search huggingface dataset:
Radon
Authors: H. Frumkin, J. M. Samet
Journal: CA A Cancer Journal for Clinicians (2001)

Residential and occupational exposure to radon is the second leading cause of lung cancer after cigarette smoking. As many as eight million homes in the US have elevated radon levels according to Environmental Protection Agency estimates. High exposure levels in homes are largely a result of radon-contaminated gas rising from the soil. This makes it an unusual indoor air pollutant in that it has a natural source. This study examines the synergism between smoking and radon, what levels are considered safe, and what to do to safeguard against overexposure to radon.
Vincristine Sulfate Liposome Injection (Marqibo®) and Rituximab For Patients With Relapsed and Refractory Diffuse Large B-Cell Lymphoma Or Mantle Cell Lymphoma In Need Of Palliative Therapy
Authors: Lawrence D. Kaplan, Steven R. Deitcher, Jeffrey A. Silverman, Gareth J Morgan
Journal: Blood (2013)
Private Dollars Increasingly Fuel Scientific Research
Journal: JNCI Journal of the National Cancer Institute (1991)

Private Dollars Increasingly Fuel Scientific Research Get access JNCI: Journal of the National Cancer Institute, Volume 83, Issue 21, 6 November 1991, Pages 1526–1527, https://doi.org/10.1093/jnci/83.21.1526 Published: 06 November 1991
Proctology
Authors: E. Parker Hayden
Journal: New England Journal of Medicine (1950)

THIS report on progress in proctology concerns the following general subjects of interest: new books; anatomy; ulcerative colitis; complications of diverticulitis; perforation of the colon and rectum; unusual proctologic cases; megacolon; cancer; and publications of the American Proctologic Society and the Section of Proctology of the Royal Society of Medicine.New BooksThree books on the subject of diseases of the colon and rectum have been published since the last review of proctologic subjects in the Journal. Late in 1948 a fourth edition of Gabrie1's1 The Principles and Practice of Rectal Surgery was brought out in this country . . .
Hand Hygiene and <i>Clostridium difficile</i>
Authors: Ted W. Gay
Journal: Annals of Internal Medicine (2007)

Letters3 July 2007Hand Hygiene and Clostridium difficileTed W. Gay, MDTed W. Gay, MDFrom Tri-City Medical Center, Oceanside, CA 92056.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-147-1-200707030-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In the Infection Control section of his otherwise excellent review of the epidemic strain of Clostridium difficile, Bartlett (1) notes that standard recommendations of the Society for Healthcare Epidemiology of America include “soap and water for handwashing rather than alcohol-based hand hygiene” (1). However, the reference cited is a Society for Healthcare Epidemiology of America position paper from 1995 that does not even address alcohol-based hand hygiene (2). Indeed, the authors of the position paper reviewed the available information on hand decontamination with nondisinfectant soap versus disinfectant soap and water and concluded that “the emphasis should be ...References1. Bartlett JG. Narrative review: the new epidemic of Clostridium difficile-associated enteric disease. Ann Intern Med. 2006;145:758-64. [PMID: 17116920] LinkGoogle Scholar2. Gerding DN, Johnson S, Peterson LR, Mulligan ME, Silva J. Clostridium difficile-associated diarrhea and colitis. Infect Control Hosp Epidemiol. 1995;16:459-77. [PMID: 7594392] CrossrefMedlineGoogle Scholar3. Boyce JM, Pittet D. Guideline for Hand Hygiene in Health-Care Settings. Recommendations of the Healthcare Infection Control Practices Advisory Committee and the HICPAC/SHEA/APIC/IDSA Hand Hygiene Task Force. Society for Healthcare Epidemiology of America/Association for Professionals in Infection Control/Infectious Diseases Society of America. MMWR Recomm Rep. 2002;55:1-45, quiz CE1-4. [PMID: 12418624] MedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Tri-City Medical Center, Oceanside, CA 92056.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoNarrative Review: The New Epidemic of Clostridium difficile–Associated Enteric Disease John G. Bartlett Metrics Cited byCommentary: Reexamining Methods and Messaging for Hand Hygiene in the Era of Increasing Clostridium difficile Colonization and Infection 3 July 2007Volume 147, Issue 1Page: 69-70KeywordsAlcoholsClostridium difficileConflicts of interestDecontaminationEpidemiologyHealth careHealth care providersHygieneMultidrug resistanceSoaps ePublished: 3 July 2007 Issue Published: 3 July 2007 Copyright & PermissionsCopyright © 2007 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
ASSESSMENT OF LEFT VENTRICULAR DYSFUNCTION DURING RESTING ANGINA AND RESPONSE TO NITRATES BY PHASE ANALYIS OF RADIONUCLIDE ANGIOGRAPHY
Authors: Oberdan Parodi, Paolo Marzullo, Heinrich R. Schelbert, Antonio LʼAbbate
Journal: Clinical Nuclear Medicine (1983)

Parodi, Oberdan; Marzullo, Paolo; Schelbert, Heinrich R.; L'Abbate, Antonio Author Information
Surgical Pathology.
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
In this issue
Authors: Peter Kirkpatrick Senior, Alexandra Flemming, Charlotte Harrison, Sarah Crunkhorn, Monica Hoyos, Man Tse, Mariam Faruqi, Susanne Harris, Catriona Rodwell, Isabel Woodman, Lucie Wootton, Senior Editorial Assistants, Laura Corns, Ella Lines, Judith Shadwell, Simon Fenwick Senior, Art Editors, Kirsten Lee, Patrick Morgan, Vicky Summersby, Natalie Smith
Journal: Nature Reviews Drug Discovery (2013)
Viewing the Journal of the National Cancer Institute
Authors: M. F. Stanton
Journal: CA A Cancer Journal for Clinicians (1969)

SURPRISE You've probably heard the recent rumour That a virus causes Burkitt's tumour.This breakthrough in epidemiology Is a tribute to modern methodology.A study was launched by a team of scholars, Statisticians, and Federal dollars: Randomized, stratified, double-blind, With flaws in the study hard to find, Adjusted for everything under the sun, With significance levels of point.oh.one,Their study produced irrefutable data.They analysed, programmed, corrected errata, Then fed the computer, and said, â€oe¿ Inspire us.â€•And back came their answer, â€oe¿ Computer Virus.â€•Well, they pounced on this lead like a hungry vulture, And they're growing computers in tissue culture,.â€"Reminding us all, as a generalization, That bugs in a study can be its salvation.
Abstract 4434: Th1 cytokines promotes E3 ubiquitin ligase Cullin 5 expression via STAT1 signaling cascade and enhance cul5 mediated proteasomal degradation of HER2 in HER2+/ER- breast cancer
Authors: Yongsheng Jia, Ganesan Ramamoorthi, Krithika Kodumudi, Amrita Basu, Doris Wiener, Brian Czerniecki
Journal: Cancer Research (2019)

Abstract The proto-oncogene HER2/ErbB2 overexpression occurs in 30% of invasive breast cancer patients and its critically associated with aggressive disease, metastasis and tumor recurrence. Despite advances in the treatment of HER2+ breast cancers, resistance and metastatic disease are potential obstacles. Cullin 5 (Cul 5), a scaffold protein mediates formation of the Cullin 5-RING E3 ubiquitin ligase functional complex. This complex acts on protective molecular chaperone heat shock protein (HSP90) complex and subsequently leads to polyubiquitination and proteasomal degradation of its client protein HER2/ErbB2. Reduced expression of Cul 5 in breast cancer patients can abrogates its inhibitory function and favor HSP90 mediated stabilization of HER2/ErbB2. More recently, we showed that Th1 cytokines (IFN-γ and TNF-α) decreased HER2 expression and induced senescence and apoptosis in HER2 overexpressing breast cancer cell lines. However, the role of Th1 cytokines on Cul 5 mediated regulation of HER2/ErbB2 remains unknown. In the present study, low level expression of Cul 5 was observed in various human (SKBR3, HCC1419 and JIMT1) and mouse (Tubo) HER2+/ER- breast cancer cell lines. Interestingly, treatment of HER2+/ER- breast cancer cells with Th1 cytokines increased the expression of Cul 5 and downregulated the expression of HER2. We knocked-down Cul 5 expression by specific siRNA found that treatment of Th1 cytokines failed to decrease HER2 expression in HER2+/ER- breast cancer cells. To investigate whether the mechanism of Th1 cytokines on Cul5 is via downstream signaling molecule STAT-1, we knock-down STAT-1. Silencing of STAT-1 expression prevented Th1 cytokines mediated activation of Cul 5. We also observed no effect on the inhibition of HER2 expression after Th1 cytokines treatment in HER2+/ER- breast cancer cells in which the expression of STAT-1 was knocked-down. Collectively, our findings demonstrate a novel mechanism that Th1 cytokines promote Cul 5 expression via STAT1 signaling and enhance Cul 5 mediated proteasomal degradation of HER2 in HER2+/ER- breast cancer. Enhancing Cul 5 levels may represent a new therapeutic avenue for the inhibition of HER2 overexpression and prevention of metastasis and tumor relapse. Citation Format: Yongsheng Jia, Ganesan Ramamoorthi, Krithika Kodumudi, Amrita Basu, Doris Wiener, Brian Czerniecki. Th1 cytokines promotes E3 ubiquitin ligase Cullin 5 expression via STAT1 signaling cascade and enhance cul5 mediated proteasomal degradation of HER2 in HER2+/ER- breast cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4434.
Oral Cytology
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical Thermography
Authors: R. Bowling Barnes
Journal: JAMA (1963)

WHEN ONE SPEAKS of clinical radiology, roentgenography is usually assumed to be the basis of the subject; but, in this report, thermoradiography or thermography is concerned with infrared radiations<i>spontaneously</i>emanating from the human body. Infrared energy, in the form of invisible "light" is emitted by every object whose temperature is above absolute zero; this self-emitted energy may be collected optically, transformed into proportional electrical impulses, and then converted to visible light to form a picture or thermogram.<sup>1</sup>Since the amount of infrared given off by any object is a function of its temperature, such thermograms are in reality quantitative representations of the object's surface temperature. Thermography thus constitutes a powerful tool for nondestructive testing which has been applied successfully, not only in situations in industry, but also in the field of medicine. In a sense, the human body is at all times "incandescent" or self-luminous within the infrared portion of the electromagnetic spectrum. The human
2019 American Heart Association Focused Update on Pediatric Basic Life Support: An Update to the American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care
Authors: Jonathan P. Duff, Alexis A. Topjian, Marc D. Berg, Melissa Chan, Sarah E. Haskell, Benny L. Joyner, Javier J. Lasa, S. Jill Ley, Tia T. Raymond, Robert Michael Sutton, Mary Fran Hazinski, Dianne L. Atkins
Journal: Circulation (2019)

This 2019 focused update to the American Heart Association pediatric basic life support guidelines follows the 2019 systematic review of the effects of dispatcher-assisted cardiopulmonary resuscitation (DA-CPR) on survival of infants and children with out-of-hospital cardiac arrest. This systematic review and the primary studies identified were analyzed by the Pediatric Task Force of the International Liaison Committee on Resuscitation. It aligns with the International Liaison Committee on Resuscitation's continuous evidence review process, with updates published when the International Liaison Committee on Resuscitation completes a literature review based on new published evidence. This update summarizes the available pediatric evidence supporting DA-CPR and provides treatment recommendations for DA-CPR for pediatric out-of-hospital cardiac arrest. Four new pediatric studies were reviewed. A systematic review of this data identified the association of a significant improvement in the rates of bystander CPR and in survival 1 month after cardiac arrest with DA-CPR. The writing group recommends that emergency medical dispatch centers offer DA-CPR for presumed pediatric cardiac arrest, especially when no bystander CPR is in progress. No recommendation could be made for or against DA-CPR instructions when bystander CPR is already in progress.
A Memorable Day in Medicine
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
HIV
Authors: Renslow Sherer
Journal: Annals of Internal Medicine (2001)

Medical Writings: Book Notes19 June 2001HIVRenslow Sherer, MDRenslow Sherer, MDThe CORE Center, Cook County Hospital, Rush Medical College, Chicago, Illinois. (Sherer)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-134-12-200106190-00033 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Libman H, Makadon HJ. 250 pages. Philadelphia: American Coll of Physicians; 2000. $35.00. ISBN 094316843. Order phone 800-523-1546, ext. 2600.Field of medicine: Infectious disease and HIV medicine.Audience: Physicians, nurses, and other providers who care for patients with HIV infection.Purpose: To provide an up-to-date overview of the primary care of HIV disease.Content: Topics covered include epidemiology and transmission, prevention, natural history, primary care, therapies, prophylaxis against and management of opportunistic infections, diagnosis and management of common HIV clinical syndromes, and infection control. Summary tables and key points enhance the concise presentation of an enormous body of clinical ... Author, Article, and Disclosure InformationAffiliations: The CORE Center, Cook County Hospital, Rush Medical College, Chicago, Illinois. (Sherer) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMedical journals’ conflicts of interest in the publication of book reviews 19 June 2001Volume 134, Issue 12Page: 1158KeywordsClinical epidemiologyHIVHIV diagnosis and managementInternetOpportunistic infectionsPatientsPregnancyProphylaxisSoftware toolsTreatment guidelines ePublished: 19 June 2001 Issue Published: 19 June 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
THE TOO STRENUOUS LIFE.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Drug-Related Deaths
Authors: Rudolph H. de Jong
Journal: JAMA (1977)

In this issue, members of the Boston Collaborative Drug Surveillance Program report on 24 drug-related deaths in hospitalized medical patients. The five-year study monitored more than 26,000 acutely ill patients, spanning seven countries. In this sense, the report represents an overview of therapeutic practices, and their attendant hazards, in the Western world. A death rate of nearly one per thousand (0.9 per 1,000, to be exact) may seem disquietingly high at first sight. A closer look at the study protocol, however, makes it clear that the outlook isn't all that bleak. For one, the five deaths from intravenous fluid overload weight the data unfavorably, inasmuch as the drug (ie, water plus additives) is less at fault than the mode of administration (ie, too much, too fast). Then too, the majority of drug-related deaths occurred in patients so sick as to require hospital admission; and of these, most were severely or
Closed Wounds of the Chest, and the Physician's Place in a Chest Team.--I
Authors: J. A. Nixon
Journal: BMJ (1941)

Changes in climate,' the nature of the soil, the character of weapons and missiles, render the aspect of gunshot wounds of the chest exceedingly variable.In the South African War it was decided that chest wounds were best left to the natural processes of cure.In the war of 1914-18 sepsis was so frequent in all varieties of chest wound that by 1916 Duval of the French Army and Gask of the British Army first began to apply the general rules ot surgery to lung wounds.In July, 1917, a meeting of con- sulting surgeons and physicians drew up a memorandum which was communicated as a guide to all medical units.A Guide for Medical Units Briefly the following rules were laid down:
Oxford Revisited
Authors: William C. Gibson
Journal: JAMA (1980)

WINSTON Churchill's old school song "Forty Years On" says it all. To return to Oxford 40 years after graduation is to "wonder what we were like at our work and our play." But not solely—for Oxford, always changing is largely the same. For the sake of perspective let us proceed from what was and still is, and then look at the very recent and the proposed. Precariously, down a narrow lane, (Fig 1) thronged with bicycles and tourists, I proceeded to the original gate of New College—which despite its name celebrated its 600th anniversary last year. The strong trunk of an oak tree, rough hewn and clad with iron bands, still bars the great doors against potential mobs of students. A low portal has been cut in it to allow inspection of all strangers. The stone nearby has been scuffed by thousands of feet over six centuries—some unshod, some in
President's address to the House of Delegates
Authors: J. Z. Appel
Journal: JAMA (1965)

In 1765 a handful of physicians in this city of 25,000 residents had an idea—a dream of training new physicians in a school of medicine. Their purpose was simple and direct: to have a continuing supply of trained physicians who could provide quality medical care. So, 200 years ago formal medical education in America began with the establishment of the College of Philadelphia—later to become the University of Pennsylvania. And three years later, in 1768, the first ten new physicians were graduated. Later, in this city of Philadelphia a group of 56 men, including five physicians, gathered in 1776. They too had an idea— a dream of freeing their country from tyranny, of declaring their country independent, and of unifying their countrymen. They too succeeded, for a new nation soon was to be established. Their purpose also was simple and direct: to establish a new government which would insure the
Bronchial Carcinoma
Authors: W. S. Blakemore
Journal: JAMA (1969)

This publication analyzes in detail the clinical manifestations of 4,000 cases of bronchial carcinoma treated by a single surgical group. The careful documentation reflects the candid and precise approach so characteristic of these surgeons. They have obtained an international reputation for superb technical and clinical management, and their experience and judgments are reflected in many of the presentations made here. The material has been collected from a single geographical area and thereby embodies the advantages of careful follow-up and statistical evaluation permitted with this population. A clear presentation is made in the first chapter, and the final summary provides the reader with easily accessible facts gleaned from their experiences. The intervening chapters elaborate and document the first and last with detailed presentation of specific symptoms and clinical findings pertinent to the management of patients with carcinoma of the lung. To the specialist, the book has unusual value because of the