tbuckley/cabot-search huggingface dataset:
New Names
Journal: JAMA (1974)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
From the Centers for Disease Control. Surgeon General's Conference on Agriculture
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Etiology, pathogenesis, and early diagnosis of ischemic necrosis of the hip
Authors: H. J. Griffiths
Journal: JAMA (1981)

ISCHEMIC necrosis (avascular necrosis, osteonecrosis) may occur in almost any bone of the skeleton. The most common site for ischemic necrosis is the head of the femur, and it is here that early diagnosis has proved to be most difficult. The patient often complains of pain, sometimes during a period of several months before any specific radiological findings become visible. It is possible to make the diagnosis earlier if clinical suspicion is high and certain specific roentgenograms are obtained. Many centers are using radioisotopes in an attempt to demonstrate changes before those observed radiologically. Although the computed tomographic (CT) scanner is an excellent method for confirming advanced disease, so far it has not proved useful in the diagnosis of early ischemic necrosis. <h3>The Etiology of Ischemic Necrosis</h3> The causes of osteonecrosis may be subdivided into three categories: posttraumatic (the most common), nontraumatic (including embolic small-vessel disease and abnormal deposition of
Onset and extent of platelet inhibition by loading dose clopidogrel in patients undergoing elective coronary stenting ? The PRONTO (Plavix for Reduction of New Thrombus Occurrence) trial Paul A. Gurbel, Charles C. Cummings, Amanda B. Alford, Andrew F. Meister, Victor L. Serebruany. Sinai Hospital, Baltimore, MD
Journal: Journal of the American College of Cardiology (2001)
Chronic Thyroiditis
Authors: Samuel F. Marshall, William A. Meissner, Delbert C. Smith
Journal: New England Journal of Medicine (1948)

CHRONIC thyroiditis, as evidenced by degeneration and fibrotic changes in the thyroid gland, is not a common disease entity but is encountered fairly frequently by the clinician and surgeon experienced in thyroid disease. The recognition of this pathologic process in the thyroid gland is important from the clinical aspect because its firmness, adherence and increase in size of the gland may cause it to be mistaken for malignant neoplasm arising in the thyroid gland.Classification of this type of thyroid disease has always been more or less troublesome, and loosely used and poorly defined terminology has contributed in no small . . .
Psychology and Health
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Potential of Plant Genetic Systems for Monitoring and Screening Mutagens
Authors: R. A. Nilan
Journal: Environmental Health Perspectives (1978)

Plants have too long been ignored as useful screening and monitoring systems of environmental mutagens. However, there are about a dozen reliable, some even unique, plant genetic systems that can increase the scope and effectiveness of chemical and physical mutagen screening and monitoring procedures. Some of these should be included in the Tier II tests. Moreover, plants are the only systems now in use as monitors of genetic effects caused by polluted atmosphere and water and by pesticides. There are several major advantages of the plant test systems which relate to their reproductive nature, easy culture and growth habits that should be considered in mutagen screening and monitoring. In addition to these advantages, the major plant test systems exhibit numerous genetic and chromosome changes for determining the effects of mutagens. Some of these have not yet been detected in other nonmammalian and mammalian test systems, but probably occur in the human organism. Plants have played major roles in various aspects of mutagenesis research, primarily in mutagen screening (detection and verification of mutagenic activity), mutagen monitoring, and determining mutagen effects and mechanisms of mutagen action. They have played lesser roles in quantification of mutagenic activity and understanding the nature of induced mutations. Mutagen monitoring with plants, especially in situ on land or in water, will help determine potential genetic hazards of air and water pollutants and protect the genetic purity of crop plants and the purity of the food supply. The Tradescantia stamen-hair system is used in a mobile laboratory for determining the genetic effects of industrial and automobile pollution in a number of sites in the U.S.A. The fern is employed for monitoring genetic effects of water pollution in the Eastern states. The maize pollen system and certain weeds have monitored genetic effects of pesticides. Several other systems that have considerable value and should be developed and more widely used in mutagen monitoring and screening, especially for in situ monitoring, are discussed. Emphasis is placed on pollen systems in which changes in pollen structure, chemistry, and chromosomes can be scored for monitoring; and screening systems which can record low levels of genetic effects as well as provide information on the nature of induced mutations. The value of plant systems for monitoring and screening mutagens can be improved by: greater knowledge of plant cell processes at the molecular and ultrastructural levels; relating these processes to mutagen effects and plant cell responses; improving current systems for increased sensitivity, ease of detecting genetic and chromosome changes, recording of data (including automation), and for extending the range of genetic and chromosome end points; and designing and developing new systems with the aid of previous and current botanical and genetic knowledge.
Greening the Olympic Games
Journal: Environmental Health Perspectives (1996)

Forum lower temperature, which prevents flames fronm direcdy charring the meat.t'aste p aiels judged meats cooked on the Safc Grill to he more fla- vorful and tender than those cooked on con1ventional grills.'T'he invenitioni of the Safe Grill was funded by National Cancer Institute to reduce the threat of cancer fi-om ifods.
Tumor Registry
Authors: John C. Ruckdeschel
Journal: JAMA (1973)

<h3>To the Editor.—</h3> In his letter, Dr. Kenneth B. Olson pleads the case for increased support of tumor registries (225:1533, 1973). I would like to add my voice in support. Our article was indeed indebted to the services of the tumor registry.<sup>1</sup>The base line data on survival of all lung cancer cases would not have been obtainable in any other fashion. The former report from that institution was in 1954.<sup>2</sup>No amount of chart review could have located those 411 cases with 22% five-year survival from which we assumed that our control group of 34 with an 18% five-year survival was a representative sample. The value of the registry extended beyond normal data collection, and was implemented by scanning obituaries of local newspapers, contacting all outstanding cases yearly and knowing many of the patients and their families personally. I would like to correct one statement of Dr.
Patients and Tablets
Authors: A. M. W. Porter
Journal: BMJ (1966)

One and a half hours later the right testicle was explored under local anaesthesia.At opera- uon it was found to be very oedematous and congested, and rotated through 180°.There was no evidence of a haematoma.The cord was untwisted and the testicle anchored to the scrotal wall.The wound was drained.The patient made an uneventful recovery, apart from post- operative retention of urine, for which he had to be catheterized on one occasion.He was seen subsequently on 30 April 1965 at follow-up when he was found to have a normal-sized testicle.
Abstract 2: Functional and mechanistic interrogation of BET bromodomain degraders for the treatment of metastatic castration resistant prostate cancer
Authors: Steven Kregel, Rohit Malik, Irfan A. Asangani, Kari Wilder-Romans, Xia Jiang, Ingrid J. Apel, Gautham Ravi, Jean Tien, Xuhong Cao, Felix Y. Feng, Corey Speers, Shaomeng Wang, Arul M. Chinnaiyan
Journal: Cancer Research (2017)

Abstract Metastatic castration-resistant prostate cancer (mCRPC) is a lethal disease with about 30,000 estimated annual deaths in U.S, with a vast majority of CRPC driven by androgen receptor (AR) signaling. AR-signaling is critical for the development and progression of prostate cancer, and AR also the main therapeutic clinical target. AR-targeted therapies, such as AR-antagonists, provide substantial benefits in the treatment of mCRPC; however, majority of patients fail these therapies and succumb to the disease. Therefore, there is a clear and pressing need to develop new therapeutics against the AR axis in CRPC. One such novel strategy for targeting the AR-pathway and inhibiting the growth of CRPC has been the use of bromodomain and extraterminal (BET) protein inhibitors such a JQ1. However, a new class of molecules that target BET bromodomain proteins through their proteasomal degradation can improve efficacy and specificity of these inhibitors. Based on our findings, we hypothesized that pharmacologic BET degradation represents an important advance in the treatment of CRPC, and may provide a novel therapeutic strategy for advanced prostate cancer. These inhibitors affect AR-positive prostate cancer cells preferentially over AR-negative and benign prostate epithelial cells, and proteomic and genomic mechanistic studies confirm disruption of oncogenic AR and MYC signaling, both in vivo and in vitro. The overall goal is to develop very potent small molecule that leads to the proteasomal-degradation of BET proteins, with optimized in vivo properties, and to provide a compelling scientific rationale, including detailed mechanistic insight, to facilitate advancement of BET degraders as a novel potential therapeutic strategy for patients with mCRPC. Citation Format: Steven Kregel, Rohit Malik, Irfan A. Asangani, Kari Wilder-Romans, Xia Jiang, Ingrid J. Apel, Gautham Ravi, Jean Tien, Xuhong Cao, Felix Y. Feng, Corey Speers, Shaomeng Wang, Arul M. Chinnaiyan. Functional and mechanistic interrogation of BET bromodomain degraders for the treatment of metastatic castration resistant prostate cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 2. doi:10.1158/1538-7445.AM2017-2
The Maintenance of Competence Program of the Royal College of Physicians and Surgeons of Canada
Authors: J. T. Parboosingh
Journal: JAMA (1993)

THE GOAL of the Maintenance of Competence (MOCOMP) Program of the Royal College of Physicians and Surgeons of Canada (RCPSC) is to motivate specialists to take a curriculum approach to managing their continuing medical education (CME). In Canada, "specialist" applies to all physicians who are certified fellows of the RCPSC. Of the 54 medical specialty societies in Canada, 10 are participating in the MOCOMP project and another five are negotiating participation. The MOCOMP is completing the second year of its pilot phase; on September 13, we should address all 54 specialty societies and hope that they, too, will join the program. In the MOCOMP Program, individual specialists set up a personal CME curriculum that includes an objective assessment of their practice needs, use of self-directed (eg, journal reading, literature retrieval) and group CME resources (eg, rounds, conferences) selected on the basis of a credit system that rewards participation in practice-based
Environmental exposure to chromium compounds in the valley of León, México
Authors: M A Armienta-Hernández, R Rodríguez-Castillo
Journal: Environmental Health Perspectives (1995)

The effects on the environment and health of the operation of a chromate compounds factory and tanneries in the Le6n valley in central M6xico are discussed.Sampling and analysis of chromium were performed in water, soil, and human urine.Groundwater has been polluted in an area of about 5 km by the leaching of a solid factory waste, which results in concentrations up to 50 mg/l of hexavalent chromium.The plume shape and exten- sion appear to be controlled by the prevailing well extraction regime.Total chromium was detected in the soil around the factory as a result of both aerial transport and deposition of dust produced in the chromate process and irrigation with tannery-contaminated water.Analysis of the impact of chromium in air and water on populations with various degrees of exposure revealed that highly harmful health effects were not observed.
La rachianesthésie: Sa valeur et sa place actuelle dans la pratique.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE "LOCAL" WASSERMANN REACTION
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction: References
Authors: JAMES A. KRICK
Journal: Annals of Internal Medicine (1975)

Comments and Corrections1 June 1975Correction: ReferencesJAMES A. KRICK, M.D.JAMES A. KRICK, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-82-6-859_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We have discovered a serious error in our paper "NocardiaInfection in Heart Transplant Patients" (Ann Intern Med82:18-26, 1975). References 20 through 24 are incorrect and should read as follows:...20. BUJAK J, OTTESEN E, and DINARELLO C: Nocardiosis in a child with chronic granulomatous disease. J Pediatr 83:98-100, 1973 CrossrefMedlineGoogle Scholar21. MARCOVITCH H and NORMAN A: Treatment of nocardiosis. Lancet 2:362-363, 1970 MedlineGoogle Scholar22. PIER A, THURSTON J, and LARSEN A: A diagnostic antigen for nocardiosis: comparative tests in cattle with nocardiosis and mycobacteriosis. Am J Vet Res 29:397-403, 1968 Google Scholar23. BREED R, MURRAY E, and HITCHENS A: Bergey's Manual of Determinative Bacteriology, 6th ed. Baltimore, The Williams and Wilkins Company, 1948, p. 897 Google Scholar24. NELSON E and HENRICI A: Immunologic studies of actinomycetes, with special reference to the acid-fast species. Proc Soc Exp Biol Med 19:351-352, 1922 CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JAMES A. KRICK, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1975Volume 82, Issue 6Page: 859-859KeywordsHeartNocardia ePublished: 1 December 2008 Issue Published: 1 June 1975 PDF downloadLoading ...
Unwanted variations in the rules of practice
Authors: J. E. Wennberg
Journal: JAMA (1991)

<i>Consensus</i>, as Webster reminds us, signifies "general agreement or unanimity; group solidarity in sentiment and belief."<sup>1</sup>The article by Kellie and Kelly in this issue ofThe Journal<sup>2</sup>confirms, once again, that there is little general agreement in medicine, and group solidarity about the standards of practice seems localized to geographic area and medical specialty. The authors demonstrate wide variations across the nation in the rules that professional review organizations (PROs) have adopted for evaluating whether physicians should be allowed to undertake a carotid endarterectomy, remove a cataract, or implant a pacemaker. The PRO guidelines often depart substantially from nationally developed practice guidelines. The work by Kellie and Kelly carries an important message. The strategies of micromanaged care have led to the development of a plethora of rules to govern clinical practice. Some, as in the case of the PRO, are at least accessible to analysis. Many others,
Economic impact of a botulism outbreak. Importance of the legal component in food-borne disease
Authors: J. M. Mann
Journal: JAMA (1983)

Legal expenses arising from food-borne outbreaks have not been reported in the medical literature, to the best of our knowledge. Expenses of an outbreak of food-borne botulism involving 34 victims in 1978 exceeded $5.8 million. These included outbreak investigation and control (3.2% of total), medical care for patients with botulism from April 1978 through October 1981 (12.3%), and settlements and legal charges (84.4%). Legal actions following food-borne outbreaks must be recognized for several reasons. First, the delay between the outbreak and the conclusion of legal activity (three years in this instance) mandates prompt and meticulous written documentation of investigation and control work. Second, legal expenses may make a large contribution to the total societal impact of food-borne disease outbreaks. Finally, awareness of the legal expense strengthens the rationale for public and private expenditures on food-borne disease prevention in this country. (<i>JAMA</i>1983;249:1299-1301)
Hot flushes in a 76-year-old man
Authors: Kent R. Kreider
Journal: JAMA (1986)

<h3>To the Editor.—</h3> In the QUESTIONS AND ANSWERS section ofThe Journal,<sup>1</sup>there was a question concerning flushing in a 76-year-old man. The two replies failed to mention a low testosterone level as a cause of flushing. <h3>Report of a Case.—</h3> In November 1976, I saw a 48-year-old man who had sweating and hot flushes. He was afebrile and had a positive tuberculin test result but a normal chest roentgenogram, and he was treated with isoniazid for a year. Because his flushes continued, in December 1977 a serum testosterone value was obtained, which was 40 μg/dL (normal range, 400 to 1,000 μg/dL). He also had a low luteinizing hormone level, 3.5 mIU/mL (normal range, 4 to 22 mIU/mL), a normal prolactin value, and a normal cortisol level. Thyroid function study values were low; the free thyroxine index was 13 (normal range, 18 to 46). A computed tomographic scan of