tbuckley/cabot-search huggingface dataset:
Hospital Gown
Authors: Barbara Seaman
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ethnic stereotypes and the underachievement of UK medical students from ethnic minorities: qualitative study
Journal: BMJ (2008)

Objective To explore ethnic stereotypes of UK medical students in the context of academic underachievement of medical students from ethnic minorities.Design Qualitative study using semistructured one to one interviews and focus groups.Setting A London medical school.Participants 27 year 3 medical students and 25 clinical teachers, purposively sampled for ethnicity and sex.Methods Data were analysed using the theory of stereotype threat (a psychological phenomenon thought to negatively affect the performance of people from ethnic minorities in educational contexts) and the constant comparative method.Results Participants believed the student-teacher relationship was vital for clinical learning.Teachers had strong perceptions about "good" clinical students (interactive, keen, respectful), and some described being aggressive towards students whom they perceived as quiet, unmotivated, and unwilling.Students had equally strong perceptions about "good" clinical teachers (encouraging, interested, interactive, non-aggressive).Students and teachers had concordant and well developed perceptions of the "typical" Asian clinical medical student who was considered over-reliant on books, poor at communicating with patients, too quiet during clinical teaching sessions, and unmotivated owing to being pushed into studying medicine by ambitious parents.Stereotypes of the "typical" white student were less well developed: autonomous, confident, and outgoing team player.Direct discrimination was not reported.Conclusions Asian clinical medical students may be more likely than white students to be perceived stereotypically and negatively, which may reduce their learning by jeopardising their relationships with teachers.The existence of a negative stereotype about their group also raises the possibility that underperformance of medical students from ethnic minorities may be partly due to stereotype threat.It is recommended that clinical teachers be given opportunities and training to encourage them to get to know their students as individuals and thus foster positive educational relationships with them.
Predictors of complete pathological response (pT0) to neoadjuvant chemotherapy (NAC) in muscle-invasive bladder carcinoma (MIBC).
Authors: Venkata Kiran Pokuri, Johar R. Syed, Zhengyu Yang, Erinn P. Field, Susanna Cyriac, Gissou Azabdaftari, Roberto Pili, Ellis Glenn Levine, Donald L. Trump, Alan Hutson, Khurshid Guru, Saby George
Journal: Journal of Clinical Oncology (2015)

e15534 Background: Randomized trials support the use of cisplatin based NAC in MIBC due to survival advantage which appeared to correlate with down staging of the cancer to pT0. However, only 30-40% of patients receiving NAC attain pT0 response at cystectomy and the remaining have either residual disease or progression. Aim of our study is to identify factors that could predict a pT0 response to NAC. Methods: Among 336 patients who underwent robotic cystectomy at our institute from 05/2007 to 03/2014, we identified 50 patients who received NAC for MIBC. We conducted a retrospective study dividing these 50 patients into 2 groups- pT0 group and those without pT0 (either residual or progressive disease). Factors including age, histology, hydronephrosis at initial presentation and type of chemotherapy were examined by both univariate and multivariate logistic regression analysis. The tests were two-sided with alpha = 0.05. Results: Fourteen (28%) of the 50 patients had pT0 at cystectomy, 20 (40%) had progressive disease and 16 (32%) had residual disease. Median age of the cohort was 67.5 years, median glomerular filtration rate at presentation was 87.5 ml/min, median number of NAC cycles was 3 and median time from end of chemotherapy to surgery was 4 weeks. The odds of pT0 response for pure urothelial carcinoma (UC) was approximately 11 times higher relative to cancers with transitional cell variant histologies or mixed tumors [Odds Ratio, 0.09; 95% CI, 0.021 to 0.380; p = 0.0011], including squamous, glandular differentiation, small cell, micropapillary, sarcomatoid, nested component, lymphoepithelioma and plasmacytoid variants. Absence of hydronephrosis favored pT0 response without statistical significance. Conclusions: In this study, presence of pure UC favored pT0 response to NAC as compared to those with variant histologies/mixed tumors. The results and trends are hypothesis generating. These potential predictors warrant further investigation in larger studies which could lead to ideal selection of patients for NAC. Histopathology pT0 [n = 14] Non pT0 [n = 36] Odds ratio (Confidence Intervals) P value Variant histology Or mixed 5 31 0.09 (0.021 - 0.380) 0.0011 Pure transitional 9 5
MedisGroups
Authors: Raymond Cogen
Journal: JAMA (1989)

<h3>To the Editor. —</h3> As a physician practicing in Pennsylvania, I read with growing alarm the recent article by Drs Iezzoni and Moskowitz.<sup>1</sup>The authors point out that MedisGroups severity weights are highly influenced by the use of specialized diagnostic technologies. They conclude that this fact might make patients admitted to teaching hospitals, where such procedures are more commonly used, seem more ill than analogous patients admitted to community hospitals. The influence of such technologies also might affect the severity-adjusted mortality rates of patients in nursing homes and reflect on their treating physician. Patients with moderate to severe Alzheimer's disease who are admitted to hospitals are less likely to receive high-technology procedures. For example, such a patient is much less likely to undergo endoscopy for upper gastrointestinal tract bleeding because of surrogate (ie, family member) refusal to give consent, even if the attending physician wishes to use such an
Pulse
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Valproic acid in epilepsy
Authors: S. Livingston
Journal: JAMA (1979)

<h3>To the Editor.—</h3> We are writing in regard to the article "Valproic Acid (Depakene): A New Anticonvulsant Agent" (240:2190, 1978), in which Lewis presented a succinct review of the literature relative to the efficacy and toxicity of this drug. His conclusion that valproic acid "is most effective in absence seizures (simple and complex)" and "has produced improvement in tonic-clonic seizures, mixed absence with tonic-clonic seizures, and myoclonic epilepsy" may lead the reader, especially in view of the publicity in the public media before Food and Drug Administration approval, to believe that valproic acid may well be the long-sought "ideal anticonvulsant." Since our experience with valproic acid does not parallel the findings described by Lewis and conflicts with the advance enthusiasm relative to efficacy, we would like briefly to present our results in 48 patients treated with this drug. To avoid the inherent complexities and nosologic confusion associated with the International
507 One year double-blind immunotherapy (IT) trial with mPEG-modified (mPEG) and the corresponding unmodified (DER.P.) mite allergen preparations in adult mite asthmatics. I. In vivo results
Authors: A. Basomba, A. Almodovar, A. Campos, A. García Villalmanzo, A. Peleaz, I. Ljungstedt-Pȧahlman, S. Dreborg
Journal: Journal of Allergy and Clinical Immunology (1988)
DIPG-13. TRANSCRIPTIONAL DEPENDENCIES IN DIFFUSE INTRINSIC PONTINE GLIOMA
Authors: Surya Nagaraja, Nicholas Vitanza, Pamelyn Woo, Kathryn Taylor, Fang Liu, Lei Zhang, Meng Li, Wei Meng, Anitha Ponnuswami, Wenchao Sun, Jie Ma, Esther Hulleman, Tomek Swigut, Joanna Wysocka, Yujie Tang, Michelle Monje
Journal: Neuro-Oncology (2017)

Diffuse intrinsic pontine glioma (DIPG) is a fatal pediatric brain tumor with limited therapeutic options. The majority of cases of DIPG exhibit a mutation in histone 3 (H3K27M) that results in oncogenic transcriptional aberrancies. We show here that DIPG is vulnerable to transcriptional disruption using either bromodomain inhibition or CDK7 blockade. We observe that targeting oncogenic transcription through either of these methods synergizes with HDAC inhibition and that DIPG cells resistant to HDAC inhibitor therapy retain sensitivity to CDK7 blockade. Furthermore, identification of super-enhancers in DIPG provides insights toward the cell of origin, highlighting oligodendroglial lineage genes, and reveals unexpected mechanisms mediating tumor viability and invasion, including potassium channel function and EPH-ephrin signaling. The findings presented here demonstrate transcriptional vulnerabilities of DIPG and elucidate previously unknown mechanisms of DIPG pathobiology.
Caring for elderly: challenge for now and 21st-century medicine
Authors: K. Simmons
Journal: JAMA (1986)

The number of Americans aged 65 years or older is expected to double in the next 50 years. And, while comparatively few of today's physicians still will be practicing a half-century from now, most are aware that assuring high-quality care for older Americans already is a serious challenge. Among organizations addressing this challenge today are the American Medical Association, the American Association of Retired Persons, the American Hospital Association, and the American Nurses' Association. The four organizations have cosponsored a national conference on the theme of "Health Policy and Quality of Care for Older Americans" (held in Alexandria, Va) at which (then) AMA President Harrison L. Rogers, Jr, MD, emphasized that the medical profession is "in a very significant period of transition." Rogers' message: Medicine is emerging from a period during which "the emphasis was on care— whatever was needed, whenever it was needed, using whatever human, chemical, or technological
Erratum: A mouse model for the learning and memory deficits associated with neurofibromatosis type I
Authors: A J Silva, P W Frankland, Z Marowitz, E Friedman, G Lazlo, D Cioffi, T Jacks, R Bourtchuladze
Journal: Nature Genetics (2002)

GenBank accession numbers for the new genes reported in this article were erroneously omitted.
Busulfan treatment during pregnancy
Authors: J. P. Machado
Journal: JAMA (1967)

<h3>To the Editor:—</h3> The subject of Dr. Corner's article "A Man With a Fine Talent for Idleness" (<b>200</b>:53, 1967), James Bridie, does not seem to be as well known in the United States as he deserves. Because of his activities at the university, Bridie belonged to that group of people who, in a different environment, might have been called dilettantes. Yet, to my knowledge, as Dr. Osborne H. Mavor he was a professor of medicine at Anderson College in Glasgow. Undoubtedly, his training as a medical student was important, as Dr. Corner points out, to many of his plays. It is difficult to think of him separately from the word "puckish." When he had failed his anatomy three times and a new professor named Price arrived, Bridie's poem in the university magazine concluded, "O Price, let thrice suffice." So it came to pass. Unfortunately, like much of minority dialect
Societies.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Many researchers, few clinicians, using drug that may slow, even prevent, Parkinson's
Authors: P. Cotton
Journal: JAMA (1990)

PROOF that more than symptoms are relieved is elusive. But a high price and "high brow" writing may also explain the weak response to strong evidence that a drug may slow the progression of Parkinson's disease. A 10-mg/d dose of deprenyl (selegiline hydrochloride, eldepryl, Somerset Pharmaceuticals, Denville, NJ) on average, nearly doubled the time before functional disability became significant enough that patients could no longer manage their daily routine without levodopa, according to results of the 800-patient Deprenyl and Tocopherol Antioxidative Therapy of Parkinsonism (DATATOP) study (<i>N Engl J Med.</i>1989;321:1364-1371). Only 25% of patients taking deprenyl with or without alpha-tocopherol (vitamin E) progressed to that point within a year, compared with 44% of those not taking deprenyl. This result prompted researchers in the 28-center, double-blind study to put all subjects—and most patients in the investigators' own Parkinson's clinics-on the drug. Symptomatic improvement could not "by itself account for the
Incorrect Information in Patient Page
Authors: Anthony Gallagher, Tapan Mehta, David Allison
Journal: JAMA (2018)

In Reply Dr Gallagher and colleagues raise an important and legitimate point about the role of surgical skills potentially explaining the variation in complication rates within bariatric surgery COEs.More importantly, they question the lack of objective assessment of surgical skills as part of the accreditation process.We agree that there may be factors not included in the accreditation program that may influence complication rates. 1 Surgical skill is a good example of such a plausible factor. 2 As mentioned in our article, quality improvement studies are needed to identify factors associated with and ideally causative of improved outcomes. 1 Studies that explore plausible factors such as surgical skills may help explain variation in complication rates within bariatric surgery COEs and improve quality of care.
Heterogeneity of Alveolar Macrophages in Experimental Silicosis
Authors: Steven Hildemann, Claus Hammer, Fritz Krombach
Journal: Environmental Health Perspectives (1992)

The alveolar macrophage (AM) population has been shown to be heterogeneous in composition as well as in function. The aim of our study was to assess morphological and functional features of AM in an experimental model of quartz-induced lung fibrosis by flow cytometric methods. Twelve cynomolgus monkeys were exposed 8 hr/day, 5 days/week for 26 months to either normal atmosphere (n = 5) or 5 mg/m3 DQ12 less than 5 microns quartz dust (n = 7). After 20 months of exposure, we studied AM phagocytosis by incubating bronchoalveolar lavage cells with fluorescent polystyrene microspheres (mean diameter 1.91 microns). Using a fluorescence-activated cell sorter analyzer, AM subpopulations were identified via their volume/side scatter properties. After selective electronic "gating" of the AM populations, both the percentage of phagocytic AM and the mean number of ingested microspheres per AM were determined. In addition, a phagocytic index (microspheres/AM x % phagocytic AM x 10(-2) and a hypothetical total phagocytic capacity of one lung (phagocytic index x total number of AM x 10(-6) were calculated. The total bronchoalveolar lavage cell counts rose (75.6 +/- 11.3 x 10(6) versus 10.1 +/- 0.8 x 10(6)) significantly after quartz exposure. In contrast, the percentage of phagocytic AM was significantly (p less than 0.05) reduced (43.5 +/- 5.0% versus 74.2 +/- 1.4%). Flow cytometric measurements revealed the appearance of an AM subpopulation characterized by size/granularity features identical to blood monocytes. Only minimal numbers of these cells were found under normal conditions, but they constituted 50% of the entire AM population in the quartz group.(ABSTRACT TRUNCATED AT 250 WORDS)
Correction
Journal: Circulation (2015)

In the article by Smith et al, “AHA/ACCF Secondary Prevention and Risk Reduction Therapy for Patients With Coronary and Other Atherosclerotic Vascular Disease: 2011 Update: A Guideline From the American Heart Association and American College of Cardiology Foundation,” which published online November 3, 2011, and appeared with the November 29, 2011, issue of the journal (Circulation. 2011;124:2458–2473. DOI: 10.1161/CIR.0b013e318235eb4d.), several corrections were needed. The authors regret the errors. These corrections have been made to the current online version of the article, which is available at http://circ.ahajournals.org/content/124/22/2458.
GP complaint system causing confusion
Journal: BMJ (2010)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following GP complaint system causing confusion Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
A phase I trial and pharmacokinetic study of gefitinib in pediatric patients with refractory solid tumors: A Children's Oncology Group Study
Authors: N. C. Daw, W. L. Furman, C. F. Stewart, L. C. Iacono, M. Krailo, M. Bernstein, J. E. Dancey, S. Blaney, P. C. Adamson
Journal: Journal of Clinical Oncology (2004)

8522 Background: Gefitinib (ZD1839, Iressa™), an orally active inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase, is indicated in adults with refractory non-small cell lung cancer. Neuroblastoma, rhabdomyosarcoma, and high-grade gliomas are known to express EGFR. We therefore conducted a phase I trial of gefitinib in pediatric patients with refractory solid tumors. Methods: Gefitinib was administered orally once daily for 28 days, at dose levels of 150, 300, 400, and 500 mg/m2/day, to cohorts of 3 to 6 patients. Drug was continued in the absence of progressive disease or significant toxicity. Pharmacokinetic studies were performed during the first course, and plasma gefitinib concentrations were measured using a LC MS/MS method. A one-compartment model was fit to the data using ADAPT II. Results: Of the 23 patients enrolled to date, 18 patients aged 2.6 to 21.2 years (median, 14.9 years), are fully evaluable for toxicity. Two patients had dose-limiting rash at 500 mg/m2. At 400 mg/m2, 4 patients thus far have tolerated the drug without dose-limiting toxicity (DLT). Non-DLTs include nausea/vomiting (8 patients), elevated ALT/AST (6 patients), and diarrhea (5 patients). One patient with Ewing sarcoma had a partial response, and 7 patients had stable disease including 2 patients with brainstem glioma for 10 and 11+ courses. At the 400 mg/m2 dose level, the median peak gefitinib plasma concentration was 2.3 μg/mL (range, 1.5 –3.6 μg/mL) and occurred at a median of 2.4 hr (range, 2.2 –4.2 hr) after drug administration. The median apparent oral clearance for all patients studied was 14.6 L/h/m2 (range, 4.6 –25.1 L/h/m2). At the lowest dose level, the gefitinib systemic exposure in pediatric patients was comparable to that associated with antitumor activity in adults. Conclusions: Oral gefitinib is well tolerated in children and rash is dose-limiting. Accrual is ongoing at the 400 mg/m2 dose level. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration AstraZeneca
Abstracts
Journal: Annals of the Rheumatic Diseases (1951)

At the end of each section is a list of titles of articles noted but not abstracted.Not all sections may be represented in any one issue.The section " ACTH, Cortisone, and other Steroids ", which appears for the third time in the present issue,,includes abstracts and titles of articles dealing with steroid research, which although not directly concerned with the rheumatic diseases, may make an important contribution to knowledge of the scope and modus operandi of steroid therapy.
Acta Endocrinologica, Copenhagen
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal