tbuckley/cabot-search huggingface dataset:
In Brief
Journal: JAMA (1970)

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Diplococcus pneumoniae. Cellulitis in drug addicts
Authors: R. J. Lewis
Journal: JAMA (1975)

Cellulitis caused by Diplococcus pneumoniae was diagnosed in two heroin users. To our knowledge, this medical emergency, clinically indistinguishable from deep fasciitis of pyomyositis, has not previously been reported as having been caused by the agent identified in these two patients.
WANTED—A DEPARTMENT OF HEALTH.
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Error in Funding/Support
Journal: JAMA Internal Medicine (2014)

Nicholas L. Smith, PhD; Marc Blondon, MD, MS; Kerri L. Wiggins, MS, RD; Laura B. Harrington, MPH; Astrid van Hylckama Vlieg, PhD; James S. Floyd, MD, MS; Melody Hwang, MPH; Joshua C. Bis, PhD; Barbara McKnight, PhD; Kenneth M. Rice, PhD; Thomas Lumley, PhD; Frits R. Rosendaal, MD, PhD; Susan R. Heckbert, MD, PhD; Bruce M. Psaty, MD, PhD
Inflicted burns in children. Recognition and treatment
Authors: D. W. Hight
Journal: JAMA (1979)

Inflicted burns are an essential part of the battered child syndrome. One hundred forty-two nonaccidental burns (16%) were found in 872 children admitted to the burn center at the Children's Hospital of Michigan during the six-year period (1972 to 1977). Of the 1,518 cases of child abuse treated during this period, 9% were caused by intentional burns. Family instability and an inability to deal with stress in crisis were important factors in the cause of these injuries. (<i>JAMA</i>242:517-520, 1979)
Regional enteritis presenting as hypoproteinemia without intestinal symptoms
Authors: T. C. Cobb
Journal: JAMA (1969)

A 24-year-old white man had regional enteritis presenting as pedal edema eight months prior to the onset of gastrointestinal complaints. Protein-losing enteropathy was demonstrated by a 15% excretion of chromated Cr 51 serum albumin in the stool. Regional enteritis as the cause of this enteropathy was revealed by roentgenography, exploratory laparotomy, and subsequent clinical course.
The alteration of physicians' orders by nonphysicians
Journal: JAMA (1988)

<h3>To the Editor.—</h3> The article "Alteration of Physicians' Orders by Nonphysicians"<sup>1</sup>addresses a well-documented problem<sup>2,3</sup>that wastes limited health care resources and threatens patient care:<sup>4,5</sup>inappropriate use of clinical laboratory services. As described by Finn et al,<sup>1</sup>the intervention of clinical laboratory scientists (medical technologists) is effective in improving the percentage of appropriate test orders, and we agree. However, we disagree with the authors' conclusions that interventions by technically knowledgeable laboratory scientists constitute "errors in the transmission of information" and "[have] the potential to delay diagnosis, and increase unnecessary testing." On the contrary, the test-ordering process and the clinician-laboratory interface can be improved by these kinds of actions as well as by other strategies, such as clinical laboratory scientists' use of laboratory-triggered algorithms, which have the potential to reduce the time and cost of rendering diagnosis.<sup>6,7</sup> Generally, such interventions now occur on an informed but
Salmon Run
Authors: Barbara Jane Wood
Journal: JAMA (1985)

Over the last hill. Curve round, down the other side. A field, a store, the river. The clench in the belly, the long last mile. You pull in under where the pines arch over. Home. It's bare ground January, the mudslick melting heel thick. This time you leave the boots outside the door and come soft-footed for the hardwood floor warped now, and dirt-darker. You peel off layers as you take off clothes. Unwrapped, you'll come unguarded heart exposed, arms out, open and bone tender til you hesitate, then close. It's ritual and possibility, cellar stairs and attic memories, creaks and cobwebs. You come back homing to the only place where frames display the aging of your face: here, where the dust has settled in your bones and the halls limn your hollows. This is it, the one place. Here alone, over and over. Over and over, back and back
Effects of Aminoacetonitrile on Somatic and Ocular Development in the Fetal Rabbit
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cystic disease of the renal medulla in the elderly
Authors: R. S. Swenson
Journal: JAMA (1974)

A 68-year-old woman with uremia and "renal salt wasting" improved greatly with sodium repletion. Several family members had died of renal failure. Multiple, bilateral corticomedullary cysts were seen on high-dose excretory urography with nephrotomography. A 67-year-old brother with normal urinalysis and creatinine clearance values also showed corticomedullary cysts on excretory urography. Despite long-term sodium supplementation, uremia progressed inexorably and death occurred 3 1/4 years after clinical onset of disease. Cystic disease of the renal medulla was confirmed at time of autopsy. The triad of a positive family history, renal salt wasting, and progressive chronic uremia strongly suggests the diagnosis of cystic disease of the renal medulla, irrespective of the age of the patient. (<i>JAMA</i>228:1401-1404, 1974)
Correction
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TCTAP A-057 Three-Year Clinical Outcome Comparison Between Everolimus-Versus Zotarolimus-Eluting Stents in All-Comers and Diabetics
Authors: Shaopeng Xu, Seung-Woon Rha, Byoung Geol Choi, Se Yeon Choi, Jabar Ali, Harris Ngow, Ji Bak Kim, Cheol Ung Choi, Eung Ju Kim, Dong Joo Oh
Journal: Journal of the American College of Cardiology (2015)
MEDICAL EDUCATION FOR MEDICAL CULTURE.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Phase I and Pharmacologic Study of Liposomal Lurtotecan, NX 211: Urinary Excretion Predicts Hematologic Toxicity
Authors: Diederik F.S. Kehrer, Annelies M. Bos, Jaap Verweij, Harry J. Groen, Walter J. Loos, Alex Sparreboom, Maja J.A. de Jonge, Marta Hamilton, Terri Cameron, Elisabeth G.E. de Vries
Journal: Journal of Clinical Oncology (2002)

PURPOSE: To determine the maximum-tolerated and recommended dose, toxicity profile, and pharmacokinetics of the liposomal topoisomerase I inhibitor lurtotecan (NX 211) administered as a 30-minute intravenous infusion once every 3 weeks in cancer patients. PATIENTS AND METHODS: NX 211 was administered by peripheral infusion. Dose escalation decisions were based on all toxicities during the first cycle as well as pharmacokinetic parameters. Serial plasma, whole blood, and urine samples were collected for up to 96 hours after the end of infusion, and drug levels were determined by high-performance liquid chromatography. RESULTS: Twenty-nine patients (16 women; median age, 56 years; range, 39 to 74 years) received 77 courses of NX 211 at dose levels of 0.4 (n = 3), 0.8 (n = 6), 1.6 (n = 3), 3.2 (n = 6), 3.8 (n = 6), and 4.3 mg/m 2 (n = 5). Neutropenia and thrombocytopenia were the dose-limiting toxicities and were not cumulative. Other toxicities were mild to moderate. Nine patients had stable disease while undergoing treatment. The systemic clearance of lurtotecan in plasma and whole blood was 0.82 ± 0.78 L/h/m 2 and 1.15 ± 0.96 L/h/m 2 , respectively. Urinary recovery (Fu) of lurtotecan was 10.1% ± 4.05% (range, 4.9% to 18.9%). In contrast to systemic exposure measures, the dose excreted in urine (ie, dose × Fu) was significantly related to the percent decrease in neutrophil and platelet counts at nadir (P &lt; .00001). CONCLUSION: The dose-limiting toxicities of NX 211 are neutropenia and thrombocytopenia. The recommended dose for phase II studies is 3.8 mg/m 2 once every 3 weeks. Pharmacologic data suggest a relationship between exposure to lurtotecan and NX 211–induced clinical effects.
Clinical Lectures Delivered in the Out-Patient Department of the Hospital for Sick Children, Great Ormond Street
Authors: W. B. Cheadle
Journal: BMJ (1872)

CASE.-Constiatzion,-Vonziting-.Retraction toe ANeck.-Insensibi- lit)' ofPupils.-Zivdi-ocephalic Cy. -Cozvtlsionzs.-Squinting.-insen- sibility.-Bizdnzess.-Treatmen2t by IodidGe of Potassium.-Complete Re-covery.-Instances of recovery after symptoms of cerebral inflammation in children, of so serious a cnaracter as those which have occurred in the case of this little girl, Charlotte B., are extremely rare.In drawing
From the Alcohol, Drug Abuse, and Mental Health Administration
Authors: F. K. Goodwin
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Treating hyperactive children
Authors: B. Fish
Journal: JAMA (1971)

It is popular to allege that a "stimulant is<i>the</i>drug for<i>the</i>hyperactive child."<sup>1</sup>Certainly, there<i>are</i>many hyperactive children who are helped by a central nervous system stimulant. When it works, it provides economical and rapid treatment which can return the child to more normal functioning both in and out of school. The danger of this dictum is that it oversimplifies a very complex diagnostic and therapeutic problem. All too often, stimulants have been given as the only treatment for children who also required specific remediation for learning disabilities or more thorough psychiatric evaluation. In addition, some proponents of stimulants have made overoptimistic claims of easy relief which often lead to equally unnecessary disappointment and scepticism. These claims have confused the public, and led to a recent furor in the press over the thousands of schoolchildren who were supposedly receiving "mind-controlling drugs." Even though conservative estimates indicated
Radiologische Praktika
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Practitioners' Visiting List (Heretofore known as the Medical News Visiting List) for 1906.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sample size in trials of hepatitis C
Authors: Adrian M. Di Bisceglie, Bruce R. Bacon
Journal: Hepatology (2002)

achieved a 30% rate of sustained virologic remission (SVR) with combination antiviral therapy among patients with chronic hepatitis C who had not responded previously to interferon. 1 This is the highest rate reported for such a study, but one notes the drug discontinuation rate was only 5%.By comparison, discontinuation rates of 13% to 14% were observed in a recent large-scale trial of combination therapy, 2 and one suspects that the rate would be higher yet in practice.The investigators correctly pointed out that there was not a statistically significant difference in SVR rate between 24 and 48 weeks of treatment.However, the study did not have sufficient power to say whether the 9 percentage-point difference observed (36% vs. 27%) was real or not.To detect a difference of 35% vs. 25% with even 80% power would require 328 patients per group, not 62. 3 The methods section did not include an a priori power calculation or sample size estimate, so it is not clear why 124 patients were studied.This could have been a pilot study to see if a larger, randomized, controlled trial were warranted.However, one is also left with the possible conclusion that the investigators might have performed a randomized trial in which there was insufficient power to answer the question posed.
Nicorette finds new place in smoking cessation
Authors: R. Voelker
Journal: JAMA (1996)

DON'T LOOK for it side by side with the Bubblicious or Wrigley's spearmint. When made available 2 weeks ago for over-the-counter sale, Nicorette gum was stocked in most drug stores on shelves within close range of pharmacists' view. Part of the reasoning is purely practical. Nicorette is a relatively expensive smoking cessation aid. Kits that include a user's guide and audio tape come in 2 sizes. One sells for $30 and the other for $50. "We wanted to see if there would be patterns of diversion, theft, or shoplifting," said Curtis Wright, MD, medical review officer at the Food and Drug Administration's (FDA) Center for Drugs. <h3>Medical Responsibility</h3> Another part of the reasoning reflects a medical responsibility. FDA-approved labeling prohibits the sale of Nicorette to anyone younger than 18 and requires proof of age from suspected minors attempting to buy the product. In granting over-the-counter status to Nicorette, the FDA
Diagnosis and treatment of cholera in the United States. Are we prepared?
Authors: R. E. Besser
Journal: JAMA (1994)

<h3>Objective.</h3> —To assess cholera recognition and treatment by US health care workers in the largest cholera outbreak in the United States this century. <h3>Design.</h3> —We reviewed the medical records of passengers from a flight on which a cholera outbreak occurred. To determine the availability of oral rehydration solutions, we surveyed treatment facilities and referral pharmacies. <h3>Setting.</h3> —On February 14, 1992, more than 100 passengers on a flight from South America to Los Angeles, Calif, were infected with toxigenic<i>Vibrio cholerae</i>O1. <h3>Subjects.</h3> —Fifty-four of 67 passengers who sought care in California and Nevada. <h3>Results.</h3> —We reviewed the records of 54 passengers, including 39 with diarrhea and 15 without symptoms. All 17 persons who sought treatment before the outbreak was widely reported by the media had diarrhea. For 12 of these persons, recent travel to South America was noted, but only those four whose records listed cholera as a possible diagnosis were immediately hospitalized. Seven sought care again within 3 days; three were dehydrated, two of these three were hospitalized, and one of these two died. None of the 26 patients suspected to have cholera received appropriate fluids; severely dehydrated patients did not receive Ringer's lactate solution and those not severely dehydrated did not receive an oral rehydration solution. None of the facilities and pharmacies involved stocked World Health Organization oral rehydration salts solution, the preferred solution for treating cholera and other diarrheal diseases. <h3>Conclusions.</h3> —Treatment of cholera in the United States was suboptimal. Oral fluids appropriate for the treatment of cholera and other diarrheal diseases were generally unavailable. Widespread cholera in the developing world means that US physicians should be prepared to treat "imported" cases. Physicians evaluating patients with diarrhea should obtain a travel history, should consider cholera in patients returning from countries with endemic or epidemic cholera, and should instruct patients in appropriate use of World Health Organization oral rehydration salts solution or other oral rehydration solutions containing 75 to 90 mmol/L of sodium. Pharmacies and medical facilities should stock these solutions. (<i>JAMA</i>. 1994;272:1203-1205)