tbuckley/cabot-search huggingface dataset:
FDA issues draft 'concept paper' on drug company funding of CME
Authors: A. Skolnick
Journal: JAMA (1991)

THE US Food and Drug Administration (FDA) has released a draft "concept paper" on guidelines for pharmaceutical company support of scientific or educational programs. The FDA has been requesting comments on the proposed guidelines from industry, medical educators, and other interested parties. According to Dennis K. Wentz, MD, director of the American Medical Association's (AMA) Division of Continuing Medical Education and chair of the Ad Hoc Task Force on Industry-Continuing Medical Education (CME) Provider Collaboration—which includes representatives from the AMA, the Accreditation Council for Continuing Medical Education (ACCME), the pharmaceutical industry, and now observers from the FDA—the task force met last month and will meet again next week (December 12) to discuss the FDA's draft concept paper. It also will examine a proposal, by the pharmaceutical industry's Fred W. Lyons, Jr, to create a self-regulating system. <h3>Similar to ACCME, AMA</h3> The proposed FDA guidelines are not very different from the
Rituximab monotherapy in anti-HBC positive patients with multiple sclerosis or neuromyelitis optica spectrum disorders is not associated with HBV reactivation
Authors: Blanca Marzo, Ángela Vidal-Jordana, Joaquim Castrilló-Justribo, Luisa Roade, Clara Oriol, Miguel Ángel Robles, Rafael Esteban, Mar Tintoré, Maria Buti, Mar Riveiro Barciela
Journal: Journal of Hepatology (2020)
Cardiovascular and neurological effects of 4,000 mg of procaine
Authors: J. A. Wikinski
Journal: JAMA (1970)

A 39-year-old patient inadvertently received 4,000 mg of procaine hydrochloride following administration of thiopental sodium, hexafluorenium bromide, and succinylcholine chloride. Mydriasis, pupils unreactive to light, arterial hypertension, sinus tachycardia, and deepening and widening of the S wave of the electrocardiogram immediately appeared, and lasted for several minutes. The level of procaine in the blood reached a peak of 96 μg/ml, and declined slowly after that. No generalized convulsions developed. The patient recovered spontaneously with no sequelae, a fact largely attributed to the protective effect of artificial ventilation with 100% oxygen.
Clofarabine Salvage Therapy Prior to Allogeneic Hematopoietic Cell Transplantation in Patients with Relapsed or Refractory AML – Interim Results of the Bridge Trial
Authors: Jan Moritz Middeke, Stefani Parmentier, Nael Alakel, Markus Schaich, Christian Thiede, Uwe Platzbecker, Christoph Röllig, Mathias Hänel, Gernot Stuhler, Anke Morgner, Uta Eulenstein, Gerhard Ehninger, Martin Bornhäuser, Johannes Schetelig
Journal: Blood (2012)
Circulation of a Type 2 Vaccine-Derived Poliovirus--Egypt, 1982-1993
Journal: JAMA (2001)

In 1988, the World Health Assembly resolved to eradicate poliomyelitis globally by 2000. Substantial progress has been achieved toward this goal, and with the circulation of wild poliovirus eliminated in most of the world, attention has focused on examining the potential for vaccine-derived poliovirus to circulate where wild poliovirus has disappeared. During 1999, sequences of historic poliovirus isolates were examined. This report summaries the results of that study, which indicate that oral poliovirus vaccine (OPV)-derived poliovirus type 2 circulated in Egypt during the 1980s and early 1990s and caused widespread infection and paralytic disease. The findings underscore the need for countries using OPV to target communities with low vaccine coverage for intense vaccination activities to prevent circulation of both wild and vaccine-derived polioviruses.
Adult open heart surgery in New York State. An analysis of risk factors and hospital mortality rates
Authors: E. L. Hannan
Journal: JAMA (1990)

This study analyzes data from New York State's new Cardiac Surgery Reporting System, which contains information about cardiac preoperative risk factors, postoperative complications, and hospital discharge. The purposes of the study were to determine the set of significant clinical risk factors and to identify cardiac surgical centers most likely to have serious quality-of-care problems. Significant risk factors for in-hospital death were age, gender, ejection fraction, previous myocardial infarction, number of open heart operations in previous admissions, diabetes requiring medication, dialysis dependence, disasters (acute structural defect, renal failure, cardiogenic shock, gunshot), unstable angina, intractable congestive heart failure, left main trunk narrowed more than 90%, and type of operation performed. Four of the 28 hospitals had significantly higher mortality rates than expected, given the risk factors of their patients. Subsequent site visits and medical record reviews confirmed that these facilities had high percentages of quality-of-care problems among cases resulting in mortality. (<i>JAMA</i>. 1990;264:2768-2774)
Hepatology Highlights
Authors: Nicholas Russo, Robert S. Brown, Robert E. Schwartz, Russell Rosenblatt, Shirley Cohen‐Mekelburg, Monica Saumoy, Clara Tow, Yecheskel Schneider, Vikas Gupta
Journal: Hepatology (2017)

Russo, Nicholas; Brown, Robert S. Jr.; Schwartz, Robert E.; Rosenblatt, Russell; Cohen‐Mekelburg, Shirley; Saumoy, Monica; Tow, Clara; Schneider, Yecheskel; Gupta, Vikas Author Information
Information Omitted From Analyses
Journal: JAMA Psychiatry (2015)

In the Original Article titled “Higher- Order Genetic and Environmental Structure of Prevalent Forms of Child and Adolescent Psychopathology” published in the February 2011 issue of JAMA Psychiatry (then Archives of General Psychiatry) (2011;68[2]:181-189), there were 2 errors. Although the article stated that the dimensions of psychopathology were measured using parent informants for inattention, hyperactivity-impulsivity, and oppositional defiant disorder, and a combination of parent and youth informants for conduct disorder, major depression, generalized anxiety disorder, separation anxiety disorder, social phobia, specific phobia, agoraphobia, and obsessive-compulsive disorder, all dimensional scores used in the reported analyses were actually based on parent reports of symptoms; youth reports were not used. In addition, whereas the article stated that each symptom dimension was residualized on age, sex, age-squared, and age by sex, the dimensions actually were only residualized on age, sex, and age-squared. All analyses were repeated using parent informants for inattention, hyperactivity-impulsivity, and oppositional defiant disorder, and a combination of parent and youth informants for conduct disorder,major depression, generalized anxiety disorder, separation anxiety disorder, social phobia, specific phobia, agoraphobia, and obsessive-compulsive disorder; these dimensional scores were residualized on age, age-squared, sex, sex by age, and sex by age-squared. The results of the new analyses were qualitatively the same as those reported in the article, with no substantial changes in conclusions. The only notable small difference was that major depression and generalized anxiety disorder dimensions had small but significant loadings on the internalizing factor in addition to their substantial loadings on the general factor in the analyses of both genetic and non-shared covariances in the selected models in the new analyses. Corrections were made to the tables and figures to reflect these changes. This article was corrected online .
Vacation Medications
Authors: B. A. St. Andrews
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Transposition of the Great Arteries
Authors: Jacqueline A. Noonan, Alexander S. Nadas, Abraham M. Rudolph, G. B. C. Harris
Journal: New England Journal of Medicine (1960)

Routine Laboratory StudiesRoutine blood counts and urinalyses were obtained in all children, and the hematocrit was determined in the great majority. Except for slight proteinuria in 4 patients, routine urinalysis was unremarkable. Platelets were described as decreased on routine peripheral blood smear in 7 patients. Bone-marrow puncture in 1 of these revealed a hypocellular marrow. A platelet count of 31,000 was found in another. This patient also had a poor clot retraction and a low prothrombin consumption.Review of serial hemoglobin determinations in many patients confirmed the findings previously reported.31 The "physiologic anemia" normally present by two months of . . .
The Optimum Population for the United States
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract P041: Serum Magnesium and the Incidence of Coronary Heart Disease Over 20 Years of Follow-up: The Atherosclerosis Risk in Communities (ARIC) Study
Authors: Mary R Rooney, Jeffrey R Misialek, Alvaro Alonso, Aaron R Folsom, Erin D Michos, Casey M Rebholz, Lin Y Chen, Pamela L Lutsey
Journal: Circulation (2018)

Introduction: Low serum magnesium (Mg) levels have been associated with increased coronary heart disease (CHD) risk, likely acting through pathways such as hypertension, hyperglycemia or inflammation. An early (1998) ARIC paper evaluated this association, based on 319 events, and identified a sex-interaction whereby the inverse Mg-CHD association was stronger among women than men. Nearly 2,000 events have occurred since the prior publication. Hence, we sought to update the analysis. Hypothesis: We hypothesized serum Mg would be inversely and independently associated with long-term risk of CHD. Methods: A total of 14,465 ARIC study participants without CHD at visit 1 (baseline) were included. Serum Mg was measured at visit 1 (1987-89) and visit 2 (1990-92). Incident CHD events were identified through 2014 using annual telephone calls, hospital discharge lists and death certificates, and were adjudicated by physician review. Multivariable Cox proportional hazards regression models were used. Serum Mg was categorized into quintiles based on mean visit 1 and 2 concentrations. Based on prior findings in ARIC suggesting an interaction, we decided a priori to provide sex-stratified results. Results: Participants at baseline were mean±SD age 54±6y, 57% were women and 27% black. Serum Mg was 1.62±0.14 mEq/L overall, 1.62±0.14 mEq/L among women and 1.63±0.14 mEq/L among men. Over a median follow-up of 25 years, 1,939 CHD cases were identified. Overall, serum Mg was inversely and monotonically associated with CHD risk after adjustment for demographics, lifestyle factors and other CHD risk factors (Table, p-trend&lt;0.001). The association was stronger among women (HR Q5 vs Q1=0.63) than men (HR=0.83), but the sex-interaction was not statistically significant (p&gt;0.05). Conclusions: In this large community-based cohort, serum Mg was inversely associated with CHD risk. This association was slightly stronger among women than men. Further research is needed to understand if increasing Mg levels is a useful target for CHD prevention.
Correction: Aluminium accumulation and immunosuppressive effect in recipients of kidney transplants
Journal: BMJ (1989)

Clinical details ofpill use and relation with hidradenitis suppurativa Pill used before Pill used at onset Duration from use Pill used after without development and during of pill to development development but without Age of hidradentis exacerbations of of hidradentis Part of body recurrence of hidradentis Patient (years) suppurativa hidradentis suppurativa suppurativa (months) affected Treatment suppurativa 1 26 Microgynon-30 2 Axillae Two operations Anogenital Antibiotics 2 27 Brevinor Ovranette 8 Right groin One operation Antibiotics
Changes in Bone Density With Lactation
Authors: David Klahr
Journal: JAMA (1993)

<h3>To the Editor.</h3> —The article by Sowers et al<sup>1</sup>about bone density and lactation raises several issues for those of us who treat patients with psychoses. Maintenance neuroleptic treatment is the treatment of choice for most schizophrenic patients. However, a common side effect of this treatment is hyperprolactinemia, which frequently causes galactorrhea and amenorrhea in women and erectile dysfunction and gynecomastia in men.<sup>2</sup>These results of hyperprolactinemia are frequently ignored by the treating physicians. Hyperprolactinemia itself may be the main cause of decreased bone density in women who lactate for extended periods. Sowers et al cite articles that have shown decreased bone density from prolactin-secreting adenomas. Neuroleptic-induced hyperprolactinemia has also been associated with decreased bone density.<sup>3</sup> If the decreases in bone density with lactation are due to hyperprolactinemia itself, what is the effect of having chronically high prolactin levels (although not as high as lactating mothers), as
THE SOCIAL STATUS OF MEDICAL MEN.
Journal: JAMA (1890)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
From the Health Care Financing Administration
Authors: B. C. Vladeck
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Histoplasmosis
Authors: Paul D. Klite
Journal: JAMA (1971)

<h3>To the Editor.—</h3> A recent letter (<b>217</b>:828,1971) described a case said to be chronic pulmonary histoplasmosis of 27 years' duration. The "diagnosis" was based on a positive histoplasmin skin test and nonspecific granulomas in the excised lung specimen. These criteria are not adequate. Skin tests indicate prior exposure to<i>Histoplasma capsulatum</i>or cross reactions to related organisms. The size of the skin-test reaction does not correlate with symptoms, activity, prognosis, or time of exposure. Chronic histoplasmosis can only be diagnosed by culture of the organism or demonstration of the typical yeast forms in microscopic sections. In acute histoplasmosis, serologic and epidemiologic history are also supportive. The list of dubious syndromes should not be lengthened.
Cord Serum Immunoglobulin E Related to the Environmental Contamination of Human Placentas with Organochlorine Compounds
Authors: Eva Reichrtova, Peter Ciznar, Viktor Prachar, Lubica Palkovicova, Marta Veningerova
Journal: Environmental Health Perspectives (1999)

Allergic diseases are on the rise in both prevalence and severity, especially in industrialized coun- tries.The process of allergic sensitization needs an understanding of the role environmental fac- tors play in its development.In addition to traditionally considered air pollutants, various persis- tent organochlorine pollutants, which accumulate in the human body over a lifetime via food intake, are toxic in humans.Placental contamination by cecals may act as a biologic marker for the exposure of the mother or for the fetus via transplacental transfer.Placentas were collected from term deliveries in two Slovak regions.The samples were then analyzed for 21 selected organochlorine compounds.Specimens of cord blood from 2,050 neonates were gathered for the determination of levels of total immunoglobulin E (IgE).The regions were chosen according to their environmental ca istics: a city polluted with organic chemical industry versus a rural region devoid of industrial sources of pollution.In addition, data regarding the incidence rate of atopic eczema cases in the regions were considered.Comparisons between regions revealed that both the placental contamination with 16 of 21 organochlorine compounds and the cord serum IgE levels were significandy higher in the industrial region.The findings pointed to an associa- tion between organochlorine compounds and the higher leves oftotal IgE in newborns, signaling a higher allergic sensitization in the industrial region.This association was supported by the higher incidence rate of atopic e czmases in the population regstered in the industrial region.
Nurse triage.
Authors: S George, S Read, B Williams
Journal: BMJ (1993)

<h3>Objective:</h3> To describe clustering of death from Parkinson disease (PD) in relatives in a large US study. <h3>Methods:</h3> We analyzed the Utah Population Database resource, which includes genealogy data of more than 2.7 million individuals linked to 519,061 individuals with a Utah death certificate (DC). We identified individuals whose DC included PD as a cause of death using ICD coding. In those individuals whose Utah DC listed PD as a cause of death, the relative risk (RR) of death with PD was determined among close and distant relatives using sex-, birth year–, and birthplace-specific rates. <h3>Results:</h3> We identified 4,031 individuals whose DC indicated PD. Among 18,127 first-degree relatives of probands with a Utah DC, the RR of death with PD was significantly increased (RR = 1.82, 95% confidence interval [CI] 1.61–2.04). The RR of death with PD was also significantly increased among 40,546 second-degree relatives with a Utah DC (RR = 1.44, 95% CI 1.29–1.60) and among 93,398 third-degree relatives with a Utah DC (RR = 1.10, 95% CI 1.03–1.18). <h3>Conclusions:</h3> Significant evidence for excess familial clustering was observed for PD deaths. The excess familial clustering and the significantly elevated RRs for PD among close and distant relatives strongly support a genetic contribution to PD mortality. These results confirm and expand the results of previous studies of PD by quantifying the risk of PD death among more distant relatives.
DEPRESSANT DRUGS AND SUDDEN DEATHS.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal