tbuckley/cabot-search huggingface dataset:
Abstract 137: Deficiency of Senescence Marker Protein 30 Exacerbates Doxorubicin-Induced Cardiac Dysfunction in Mice
Authors: Makiko Miyata, Satoshi Suzuki, Tomofumi Misaka, Shu-ichi Saitoh, Yasuchika Takeishi
Journal: Circulation Research (2012)

Background: Senescence marker protein 30 (SMP30) was originally identified as an aging marker protein in the rat liver. The expression of SMP30 decreases with aging androgen-independently. Doxorubicin (DOX) has been used as a potent anticancer agent, but serious cardiotoxicity precludes its use in a wide range of patients. SMP30 may have anti-oxidative and anti-apoptosis functions in several organs, but functional role of SMP30 has not been rigorously examined in the heart. We hypothesized that SMP30 has cardio-protective function by anti-aging and anti-oxidant effects on DOX-induced cardiac dysfunction. Method and Results: Male SMP30 knockout (SMP30KO) and age-matched littermate male wild-type (WT) mice at 12-14 weeks of age were given intraperitoneal injections of DOX (20 mg/kg) or saline. Seven days after DOX injection, echocardiography revealed that left ventricular ejection fraction in DOX-treated SMP30KO mice was more severely reduced than in DOX-treated WT mice (40.9 ± 3.1% vs. 46.9 ± 4.9%, P&lt;0.01). Morphological examination of myocardial sections showed fibrotic change in DOX-treated SMP30KO mice significantly increased compared to DOX-treated WT mice (3.2 ± 0.5% vs. 1.3 ± 0.2%, P&lt;0.01). Generation of reactive oxygen species assessed by dihydroethidium staining was greater in DOX-treated SMP30KO mice than DOX-treated WT mice (166.9 ± 8.6% vs. 131.6 ± 5.8%, P&lt;0.01). Moreover, apoptotic signaling pathways such as caspase-3 activity (1.8 ± 0.1% vs. 1.1 ± 0.2%, P&lt;0.01), bax/bcl-2 ratio (2.4 ± 0.3% vs.1.6 ± 0.2%, P&lt;0.05) and phosphorylation activity of c-Jun N-terminal kinase (1.6 ± 0.3 vs. 1.0 ± 0.1, P&lt;0.05) were significantly elevated in the SMP30KO mice compared with WT mice after DOX injection. The numbers of TUNEL-positive nuclei in the myocardium were higher in DOX-treated SMPKO mice than in DOX-treated WT mice (0.15 ± 0.02% vs. 0.08 ± 0.01%, P&lt;0.01). Conclusions: The results of this study demonstrated that DOX-induced cardiotoxicity is aggravated in SMP30KO mice by exacerbating of superoxide generation, leading to enhanced apoptosis of cardiomyocytes. SMP30 has a cardio-protective role by anti-apoptotic and anti-oxidative effects in DOX-induced cardiotoxicity.
From the Alcohol, Drug Abuse, and Mental Health Administration
Authors: Donald Ian Macdonald
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A statewide mass measles immunization program
Authors: E. B. Byrne
Journal: JAMA (1967)

Increased demand for medical services and school absenteeism related to vaccine reactions following a oneday mass measles immunization program in Rhode Island were studied. Measles virus vaccine, live, attenuated (Schwarz) was used. Nearly 60% of susceptible children (30,647) were immunized. Increased demand for medical services averaged less than one telephone call per day per physician during the week when most reactions occurred. For two weeks preceding immunization, however, many physicians experienced a sharp increase in calls from parents requesting immunization histories of their children. School absenteeism among those vaccinated was higher by 3.5% throughout the state, except in certain communities where epidemic influenza B morbidity was reaching peak levels. Here, absenteeism patterns were reversed. Interferon induced in those vaccinated by the measles virus vaccine is suggested as an explanation for the apparent protective effect against influenza B.
Bone Refraction After Partial Gastrectomy
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction
Journal: BMJ (1960)

MEDICALBJORNALAny Questions ?We puiblish below a selection of those questions and answers which seem of general interest.It is regretted that it is not possible to supply answers to all questions suibmnitted.High-protein Diet in Myopia Q.-Will a high-protein diet prevent the progressioni of myopia ?If so, is such a diet feasible ?A.-There is some evidence' that myopia progresses more in children who are growing fast and who do not like some protein-containing foods.Although this evidence is not con- clusive, and it does not necessarily follow that a high-protein diet will prevent the progression of myopia, it seems worth attempting to supplement the diet of such children with animal protein.The feasibility of such a diet depends mainly on the social circumstances.Foods containing first- class protein are expensive and it may be difficult to arrange special diets for children at boarding school.
Effect of Soy Protein Supplementation on Serum Lipids:
Authors: Jiang He, Dongfeng Gu, Xigui Wu, Xiufang Duan, Paul K. Whelton
Journal: Circulation (2001)

0029 Clinical trials have indicated that soy protein supplementation reduces blood cholesterol in patients with hypercholesterolemia and in postmenopausal women. We examined the effect of soy protein supplementation on serum lipids in a randomized, double-blinded, placebo-controlled trial. A total of 60 male and 90 female study participants aged 35 to 65 years were recruited from the community in Beijing, China. They were randomly assigned to receive 40 g isolated soy protein per day (n=76) or complex carbohydrate placebo (n=74) for 12 weeks. Fasting serum total cholesterol, HDL-cholesterol, and triglyceride were measured at baseline, and at interim (6 wks) and termination (12 wks) follow-up visits using standard methods. Overall, 92.0% (138/150) of the study participants completed the trial. The results were determined using an intention-to-treat analysis. At baseline, the supplementation and control groups were similar in age (55.8 vs. 55.9 yrs), blood pressure (135.9/82.6 vs. 134.5/82.2 mm Hg), weight (70.1 vs. 67.7 kg), total cholesterol (201.2 vs. 205.5 mg/dl), HDL-cholesterol (44.3 vs. 45.6 mg/dl), LDL-cholesterol (129.7 vs. 129.7 mg/dl), and triglyceride (135.7 vs. 151.1 mg/dl) levels. Compared to the carbohydrate control group, the soy protein supplementation group had a net increase in serum lipid of 3.3% (p=0.047) for total cholesterol, 4.7% (p=0.038) for HDL-cholesterol, 3.0% (p=0.21) for LDL-cholesterol, and 2.6% (p=0.67) for triglyceride levels. Our study suggests that soy protein intake may increase HDL-cholesterol but not affect LDL-cholesterol significantly in populations with a normal blood cholesterol level and consumption of a relatively low animal protein diet.
THE POINT OF VIEW
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Problemy Endokrinol i Gormonoterapii, Moscow
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Brucellosis control
Authors: W. R. Barclay
Journal: JAMA (1980)

Modern medicine has reduced morbidity and mortality primarily through the control of infectious diseases. Unfortunately, we may have grown too complacent about this success, believing that infectious diseases require relatively little in continuing or new effort to achieve their suppression or eradication. Consequently, physicians have turned the greater part of their research and clinical interest to degenerative, cardiovascular, and neoplastic diseases. In this issue ofThe Journal(p 2318), Robert I. Wise, MD, PhD, reviews the problem of eradicating brucellosis from animal herds and man, a challenge with profound economic as well as health implications. Brucellosis is transmitted from animal to animal and from animal to man but seldom from man to man. Breaking the chain of transmission demands full cooperation among farmers, abattoirs, government, veterinarians, and physicians. The responsibility of physicians is relatively simple and straightforward: they must recognize the disease when they encounter it and must promptly report
Furuncular Myiasis
Authors: Paul B. lannini
Journal: JAMA (1975)

We saw two cases of cutaneous myiasis from the larvae of the botfly,<i>Dermatobia hominis</i>. The first patient acquired the disease in Brazil, the second in Guatemala. The appearance is quite similar to furunculosis, but is not responsive to antibiotic therapy. Surgical excision is the treatment of choice. (<i>JAMA</i>233:1375-1376, 1975)
IMMUNITY.CHAPTER XXII (Concluded).
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Appointments
Authors: Bonnie Salomon
Journal: Annals of Internal Medicine (2011)

Ad Libitum6 September 2011AppointmentsBonnie Salomon, MDBonnie Salomon, MDFrom Northwestern Lake Forest Hospital, Lake Forest, IL 60045-9989.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-155-5-201109060-00027 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Meet me at 2:45 in the morningTrauma bay one, first room on the rightI'll be the one in green scrubs, sipping coffeeWaiting for you to go through a red light.It's been a slow night so farGod knows that can't last forever—And now here you are, always on timeWearing a collar so stiff you can't moveOn a board forcing you rigid and straight as a knife.Welcome, this evening, you've made your appointment.So let us begin, to set all things right.Colic your mother says, that's ... Author, Article, and Disclosure InformationAffiliations: From Northwestern Lake Forest Hospital, Lake Forest, IL 60045-9989.Current Author Address: Bonnie Salomon, MD, Northwestern Lake Forest Hospital, 660 North Westmoreland Road, Lake Forest, IL 60045-9989. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 6 September 2011Volume 155, Issue 5Page: 344KeywordsBreathingCoffeeInterleukinsLungs ePublished: 6 September 2011 Issue Published: 6 September 2011 Copyright & PermissionsCopyright © 2011 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Epidemiological problems associated with studies of the safety of oral contraceptives
Authors: D. Seigel
Journal: JAMA (1968)

Most segments of American society agree that excessive and disproportionate population growth is a social, economic, and health threat, and there is a consensus, reflected in the stated policy of the federal government<sup>1</sup>that every family should have easy access to family planning information and services so that each may make an intelligent and uninhibited choice concerning the number of children desired. This consensus has increased the need for family planning services and efforts to develop improved techniques of contraception. New methods have been developed because the old ones are not suitable for all populations. It is difficult for a single method to satisfy all the criteria of the ideal contraceptive: efficacy, safety, reversibility, low cost, simplicity, and acceptability. Advances in reproductive biology supported and conducted by private foundations, industry, and the government have resulted in several unique and effective techniques in the last decade, the most noteworthy being oral
A Hormonelike Epidermal Product Stimulates Immune Reactions
Journal: JAMA (1983)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Eosinophilia
Authors: Marc E. Rothenberg
Journal: New England Journal of Medicine (1998)

A marked accumulation of eosinophils occurs in several important disorders, such as allergic diseases, parasitic infections, and cancer.1 The level of eosinophils in the body is normally tightly regulated. In normal subjects, eosinophils account for only a small minority of peripheral-blood leukocytes, and their presence in tissues is primarily limited to the gastrointestinal mucosa.2 In certain disease states, however, eosinophils can selectively accumulate in the peripheral blood or any tissue in the body. Any perturbation that results in eosinophilia, defined here as an abnormal accumulation of eosinophils in blood or tissue, can have profound clinical effects. Eosinophilia may be harmful, . . .
Cardiac transplantation in man. Statement prepared by the Board on Medicine of the National Academy of Sciences
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A locum agency offered me a job as a senior house officer in obstetrics and gynaecology. This was confirmed by a letter. When I arrived, the job was not in my specialty. My registration with the General Medical Council says that I cannot work in any other specialty. I want to be fairly compensated by the hospital for the psychological and financial damage, but I don't want to take legal action. Can you help?
Authors: Adam Harrison
Journal: BMJ (2004)

Have a career or related problem that needs answering? Can9t find the right person to point you in the right direction? Log on to the Advice Zone (www.bmjcareers.com/advicezone) for reliable medical careers advice. You can post a question or see if one of our 300 advisers has already answered a similar question. Here is a selection of questions and answers posted on the site.
Pre-transplant sarcopenic obesity worsens the survival after liver transplantation: a meta-analysis and systematic review
Authors: Péter Jenő Hegyi, Alexandra Soós, Péter Hegyi, Zsolt Szakács, Lilla Hanák, Erika Pétervári, Gabriella Pár, Márta Balaskó, Bálint Pár
Journal: Journal of Hepatology (2020)
Phosphorylation of GSK-3β by cGMP-dependent protein kinase II promotes hypertrophic differentiation of murine chondrocytes
Authors: Yosuke Kawasaki, Fumitaka Kugimiya, Hirotaka Chikuda, Satoru Kamekura, Toshiyuki Ikeda, Naohiro Kawamura, Taku Saito, Yusuke Shinoda, Akiro Higashikawa, Fumiko Yano, Toru Ogasawara, Naoshi Ogata, Kazuto Hoshi, Franz Hofmann, James R. Woodgett, Kozo Nakamura, Ung-il Chung, Hiroshi Kawaguchi
Journal: Journal of Clinical Investigation (2008)
Glaucoma: detection before damage, fewer side effects may be possible
Authors: P. Cotton
Journal: JAMA (1990)

AN END to treatment side effects and slow, subjective, postdamage diagnosis are visible goals in glaucoma research. Several agents are under investigation that reduce intraocular pressure without the systemic side effects that plague L-timolol, the oft-prescribed drug for primary open-angle glaucoma, the most common form of the disease. Also, experimental devices that objectively measure the optic nerve and retinal nerve fiber layer may permit diagnosis and treatment before the irreversible damage that is presumably caused by high intraocular pressure. Some of the latest work in these areas was spelled out recently at a Research to Prevent Blindness seminar in Universal City, Calif. Intraocular pressure itself is now seen as a risk factor, not a diagnosis, for this second leading cause of blindness in the United States. As many as one third of eyes with glaucoma do not have high intraocular pressure when first examined. In addition, many eyes with high
CAR T Cells Drive CLL Remissions
Journal: Cancer Discovery (2017)

A new study shows that chimeric antigen receptor T cells produce objective responses in 71% of patients with chronic lymphocytic leukemia whose disease progressed despite receiving ibrutinib or who are unable to tolerate the drug. Cancer cells were undetectable in the bone marrow in 81% of tested patients, and 64% of tested patients showed complete lymph node responses. Most patients experienced adverse effects, however.
Correspondence
Authors: STEWART STIRLING
Journal: British Journal of Dermatology (1901)

Journal Article Correspondence Get access STEWART STIRLING STEWART STIRLING 4 Coates Crescent, Edinburgh Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 13, Issue 2, 1 February 1901, Page 80, https://doi.org/10.1111/j.1365-2133.1901.tb16361.x Published: 01 February 1901