tbuckley/cabot-search huggingface dataset:
Mother's Day
Authors: Ronald H. Lands
Journal: Annals of Internal Medicine (1998)

On Being a Patient1 May 1998Mother's DayRonald H. Lands, MDRonald H. Lands, MDMethodist Regional Cancer Center; Oak Ridge, TN 37830Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-9-199805010-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail When we left home this morning, she wore a plain print dress with one of my old sweaters from college draped around her shoulders. A shiny patent leather purse, larger than a small overnight case, contained a variety of trinkets of random significance. Red Nike running shoes with Velcro snaps (necessary because she cannot tie her own shoelaces) completed the ensemble. It took me more than an hour to dress her, even after allowing her to choose the outfit.Our separations at day care are always traumatic. She cries when I leave, and I try not to cry about leaving ... Author, Article, and Disclosure InformationAffiliations: Methodist Regional Cancer Center; Oak Ridge, TN 37830Corresponding Author: Ronald H. Lands, MD, 136 Amanda Drive, Oak Ridge, TN 37830. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1998Volume 128, Issue 9Page: 777KeywordsRunningShouldersUrination Issue Published: 1 May 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Carbon Monoxide Poisonings Associated With Snow-Obstructed Vehicle Exhaust Systems— Philadelphia and New York City, January 1996
Journal: JAMA (1996)

On January 9, 1996, CDC was notified about carbon monoxide (CO)-related morbidity and mortality associated with the blizzard in the northeastern United States. Most of these poisonings occurred among children and elderly persons and resulted from exposures in idling automobiles with exhaust pipes blocked by snow. This report summarizes three cases of CO poisoning reported to Philadelphia's Poison Control Center on January 8-9, and 22 cases reported in New York City on January 8-9.
Index of Authors&lt;subtitle&gt;Volume 23 July 1959 • December 1959&lt;/subtitle&gt;
Journal: JNCI Journal of the National Cancer Institute (1959)

Index of Authors: Volume 23 July 1959 • December 1959 Get access JNCI: Journal of the National Cancer Institute, Volume 23, Issue 6, December 1959, Pages 1487–1488, https://doi.org/10.1093/jnci/23.6.1487 Published: 01 December 1959
Massachusetts Medical Society
Authors: John Figgis Jewett
Journal: New England Journal of Medicine (1959)

COMMITTEE ON MATERNAL WELFARERupture of the Uterus, with Aspiration PneumonitisA thirty-five-year-old short, obese gravida 4 with 3 previous cesarean sections died fifty-three hours after admission to the hospital at twenty-six weeks because of a severe stomach-ache.The uterus was not described, but no fetal heart beat could be found and there were "no other signs of labor." She was given chlorpromazine and intravenous infusions of fluids for vomiting. Twenty-four hours later she collapsed en route to the bathroom, and rupture of the uterus was diagnosed. For eight hours shock was treated by an internist with stimulants, transfusions and . . .
Microanatomy Of Lymphoid Tissue During Humoral Immune Responses: Structure Function Relationships
Authors: A. Szakal
Journal: Annual Review of Immunology (1989)

Exhausted CD8 T (Tex) cells are a distinct cell lineage that arise during chronic infections and cancers in animal models and humans. Tex cells are characterized by progressive loss of effector functions, high and sustained inhibitory receptor expression, ...Read More
Single doses of TERN-201, a novel selective semicarbazide-sensitive amine oxidase (SSAO) inhibitor, are safe, well-tolerated, and result in sustained reduction of SSAO activity in healthy participants
Authors: Christopher Jones, Pengfei Guo, Qiong Zhang, Yujin Wang, Martijn Fenaux, Diana Chung, Erin Quirk
Journal: Journal of Hepatology (2020)
Integration of Droplet Microfluidic Tools for Single-Cell Functional Metagenomics: An Engineering Head Start
Authors: David Conchouso, Amani Al-Ma’abadi, Hayedeh Behzad, Mohammed Alarawi, Masahito Hosokawa, Yohei Nishikawa, Haruko Takeyama, Katsuhiko Mineta, Takashi Gojobori
Journal: Genomics Proteomics & Bioinformatics (2021)

Droplet microfluidic techniques have shown promising outcome to study single cells at high throughput. However, their adoption in laboratories studying "-omics" sciences is still irrelevant due to the complex and multidisciplinary nature of the field. To facilitate their use, here we provide engineering details and organized protocols for integrating three droplet-based microfluidic technologies into the metagenomic pipeline to enable functional screening of bioproducts at high throughput. First, a device encapsulating single cells in droplets at a rate of ∼250 Hz is described considering droplet size and cell growth. Then, we expand on previously reported fluorescence-activated droplet sorting systems to integrate the use of 4 independent fluorescence-exciting lasers (i.e., 405, 488, 561, and 637 nm) in a single platform to make it compatible with different fluorescence-emitting biosensors. For this sorter, both hardware and software are provided and optimized for effortlessly sorting droplets at 60 Hz. Then, a passive droplet merger is also integrated into our pipeline to enable adding new reagents to already-made droplets at a rate of 200 Hz. Finally, we provide an optimized recipe for manufacturing these chips using silicon dry-etching tools. Because of the overall integration and the technical details presented here, our approach allows biologists to quickly use microfluidic technologies and achieve both single-cell resolution and high-throughput capability (>50,000 cells/day) for mining and bioprospecting metagenomic data.
Immune characterization of the programmed death receptor pathway in high-risk prostate cancer.
Authors: Shaheen Riadh Alanee, Wesley Baas, Svetlana Gershburg, Danuta Dynda, Kristin Delfino, Kathy Robinson, Jennifer Yearley
Journal: Journal of Clinical Oncology (2017)

40 Background: Programmed Death 1 (PD-1) is a T cell inhibitory receptor critical to a major immunomodulation pathway which has been implicated in tumor evasion of immune response. PD-1 and its ligand PD-L1 have been found to be expressed in many tumor types, and this expression has led to the development of drugs targeting the PD-1 pathway. The goal of this study was to understand the expression of PD-1, and PD-L1 in high grade prostate cancer tissue, and correlate the expression with disease and patients characteristics. Methods: Immunohistochemistry for PD-1 (CD279), PD-L1 (B7-H1), and CD3 was performed on prostatectomy/biopsy tissue samples taken from 25 men with high grade (Gleason 8-10) prostate cancer using anti-PD-L1 clone 22C3 (Merck) and anti-PD-1 clone NAT105 (Cell Marque) . CD3 was used as a specific marker for T cell infiltration. Charts were then retrospectively reviewed for patient and disease characteristics including age at diagnosis, race, Gleason score, prostatic specific antigen (PSA) level at diagnosis, number of positive cores at biopsy, volume of tissue on biopsy and/or prostatectomy involved by cancer, clinical TNM stage, pathologic TNM stage, biochemical recurrence, or metastasis. Statistical analyses were done to correlate these patient and disease characteristics with PD-1, PD-L1, and CD3 expression. Results: A score of 3-5 on the semi-quantitative 0-5 score was deemed “high” expression whereas a score of 0-2 was deemed “low” expression. Of the 25 samples, 2 (8%) scored high for PD-1 expression, 2 (8%) scored high for PD-L1 expression, and 18 (72%) scored high for CD3 expression. With independent t-tests there was found to be no statistically significant correlation between any of the variables we collected and expression of PD-1, PD-L1, or CD3. Conclusions: We found an overall low expression of PD-1 and PD-L1, and a concurrent high expression of CD3+ T cells in high risk prostate cancer tissue. No significant correlations were made between expression of PD-1, PD-L1, or CD3 and patient and disease characteristics. The elevated T cell content in high risk prostate cancer is particularly interesting with the continued emergence of new drugs focused on enhancing efficacy of the immune response in cancer.
ANOTHER JUDGE DEFINES PRACTICE OF MEDICINE.
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Effect of Universal Health Insurance on Health Care Utilization in Taiwan
Authors: Cheng Shou-Hsia
Journal: JAMA (1997)

<h3>Context.</h3> —The government of Taiwan introduced universal health insurance to cover all citizens in 1995. This national health insurance program was proposed to assure the accessibility to health care at reasonable cost. Evaluation of the consequences, including health care utilization and expenditure, is crucial for policy adjustment. <h3>Objectives.</h3> —To evaluate the effect of Taiwan's national health insurance on health care utilization. <h3>Design.</h3> —Cohort survey conducted before and after the implementation of the national health insurance program. <h3>Participants.</h3> —A total of 1021 randomly selected Taiwanese adults. <h3>Main Outcome Measures.</h3> —Physician visits in the 2 weeks prior to the survey and hospital admissions and emergency department visits in the immediate past year. <h3>Results.</h3> —After the introduction of universal health insurance, the newly insured consumed more than twice the amount of outpatient physician visits (0.21 vs 0.48,<i>P</i>&lt;.05) and hospital admissions (0.04 vs 0.11,<i>P</i>&lt;.05) than before universal health insurance was implemented, bringing them to the same amount of health care contacts as the previously insured group. The newly insured also experienced an insignificant increase in emergency department visits. In contrast, the previously insured group had a small but statistically significant increase in outpatient visits (0.48 vs 0.59,<i>P</i>&lt;.05) and insignificant changes in hospital admissions and emergency department visits. <h3>Conclusion.</h3> —The universal health insurance removed some barriers to health care for those newly insured. The copayment design in the insurance scheme seemed to have an insignificant effect on curbing medical care utilization. Taiwanese health policy analysts should seriously consider the growth of health care expenditures since the implementation of universal health insurance.
Prospective study of relative weight, height, and risk of breast cancer
Authors: S. J. London
Journal: JAMA (1989)

We examined relative weight and height in relation to subsequent breast cancer risk among 115 534 women 30 to 55 years of age and free from cancer in 1976. By 1984, six hundred fifty-eight premenopausal and 420 postmenopausal breast cancers were documented during 734 716 person-years. Among premenopausal women, risk of breast cancer decreased significantly with increasing relative weight (relative risk for the highest category was 0.6). A similar inverse association was seen for recalled relative weight at 18 years of age. Postmenopausal breast cancer was not associated with relative weight, either recent or at age 18. Height was not associated with breast cancer risk among premenopausal women and only weakly related among postmenopausal women. These data suggest that obesity among premenopausal and early postmenopausal women does not increase breast cancer risk substantially. (<i>JAMA</i>. 1989;262:2853-2858)
Identification of novel immune checkpoints as targets for cancer immunotherapy
Authors: Ofer Levy, Amir Toporic, Gady Cojocaru, Liat Dassa, Ilan Vaknin, Tal Fridman Kfir, Inbal Barbiro, Eyal Neria, Arthur Machlenkin, Spencer Liang, Shirley Sameach-Greenwald, Zurit Levin, Galit Rotman, John Hunter
Journal: Journal for ImmunoTherapy of Cancer (2014)

Meeting abstracts Members of the B7/CD28 family of immune checkpoints, such as CTLA4, PD1 and PDL-1, play critical roles in T cell regulation, and have emerged as promising drug targets for cancer immunotherapy. We hypothesize that additional novel members of the B7/CD28 family play a role as
ERRATUM
Journal: Journal of Clinical Oncology (2016)

published with an error.On page 3051, column 1, final sentence, the text read, "It is recognized that in Waldeyer's ring or extranodal sites with high physiologic uptake or with activation within spleen or marrow (eg, with chemotherapy or granulocyte colony-stimulating factor [GCSF]), FDG uptake may be .normal mediastinum and/or liver.In this circumstance, CMR may be inferred if uptake at sites of initial involvement is , surrounding normal tissue, even if the tissue has high physiologic uptake."This should have read, "It is recognized that in Waldeyer's ring or extranodal sites with high physiologic uptake or with activation within spleen or marrow (eg, with chemotherapy or granulocyte colony-stimulating factor [GCSF]), FDG uptake may be .normal mediastinum and/or liver.In this circumstance, CMR may be inferred if uptake at sites of initial involvement is no greater than surrounding normal tissue even if the tissue has high physiological uptake."The online version has been corrected in departure from the print.
Pseudotumor cerebri treated with Lumbar-peritoneal shunt
Authors: G. D. Vander Ark
Journal: JAMA (1971)

Occasionally pseudotumor cerebri is refractory to all forms of medical therapy. Indications for surgical treatment are the visual complications of raised intracranial pressure. For three patients with these complications who required operative treatment, the technique of lumbar-subarachnoid-peritoneal shunt was used effectively. This technique is recommended as the surgical treatment of choice.
Status Asthmaticus
Authors: Robert M. Senior
Journal: JAMA (1975)

STATUS asthmaticus refers to a life-threatening asthmatic episode that is initially unresponsive to vigorous therapy with epinephrine, aminophylline, aerosolized bronchodilators, and hydration. Status asthmaticus must be distinguished from other causes of wheezing such as pulmonary edema, pulmonary emboli, upper airway obstruction, or an acute exacerbation of bronchitis in the patient with chronic obstructive lung disease. The asthmatic attack leading to status asthmaticus may involve a variety of processes including partial β-adrenergic blockade, immunological events, and infection, but it is probable that the final event that culminates in status asthmaticus is plugging of the airways with mucus. It is the presence of bronchial casts, rather than "bronchospasm," that accounts in large measure for the refractoriness to bronchodilators as well as the slow return of lung function to normal even after symptoms have abated. At present, little is known about the factors that govern the type and quantity of tracheobronchial mucus in
Large Families: For MDs Only?
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dr. John Alfred Morgan Is Not Dead
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reference Directories
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Liver Injury: Transactions of the Tenth Conference, May 21-22, 1951, New York, N. Y
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prognostic Value of B-Type Natriuretic Peptide in Unstable Coronary Artery Disease—Reply
Authors: David A. Morrow
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pneumothorax Due to Compressed Air Injury of the Intestine
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal