tbuckley/cabot-search huggingface dataset:
Comparative evaluation of treatments of alcohol withdrawal syndromes
Authors: T. M. Golbert
Journal: JAMA (1967)

In a clinical comparative study, 49 patients were treated for the tremulous and agitated states and acute hallucinosis of alcohol withdrawal. Thirteen patients were treated with promazine hydrochloride, and 12 each with paraldehyde and chloral hydrate, alcohol, or chlordiazepoxide hydrochloride. Of these therapies, paraldehyde with chloral hydrate was most effective and best tolerated. Twenty-three patients were treated for delirium tremens. Twelve were treated with promazine and suffered numerous complications, including death in two cases. Eleven were treated with paraldehyde and chloral hydrate with prompt clearing of hallucinations; there were no failures and only one complication (transient fever).
Thrombocytopenia and myocardial ischemia
Authors: P. Cohen
Journal: JAMA (1974)

Two patients had myocardial ischemia in a setting of chronic thrombocytopenia. Awareness of such occurrences should stimulate the reporting of other cases, so that the role of quantitative changes in platelets on the course of ischemic heart disease may receive greater attention. (<i>JAMA</i>228:1568-1569, 1974)
Mistaken Capsules
Authors: I. M. P. Smeed
Journal: BMJ (1955)

We have observed that passive tactile spatial acuity, the ability to resolve the spatial structure of surfaces pressed upon the skin, differs subtly but consistently between the sexes, with women able to perceive finer surface detail than men. Eschewing complex central explanations, we hypothesized that this sex difference in somatosensory perception might result from simple physical differences between the fingers of women and men. To investigate, we tested 50 women and 50 men on a tactile grating orientation task and measured the surface area of the participants9 index fingertips. In subsets of participants, we additionally measured finger skin compliance and optically imaged the fingerprint microstructure to count sweat pores. We show here that tactile perception improves with decreasing finger size, and that this correlation fully explains the better perception of women, who on average have smaller fingers than men. Indeed, when sex and finger size are both considered in statistical analyses, only finger size predicts tactile acuity. Thus, a man and a woman with fingers of equal size will, on average, enjoy equal tactile acuity. We further show that sweat pores, and presumably the Merkel receptors beneath them, are packed more densely in smaller fingers.
Antimicrobial effects of phototherapy and photochemotherapy <i>in vivo and in vitro</i>
Authors: M. YOSHIMURA, S. NAMURA, H. AKAMATSU, T. HORIO
Journal: British Journal of Dermatology (1996)

Summary We investigated the antimicrobial effects of phototherapy and photochemotherapy in vivo and in vitro. First, Staphylococcus aureus samples were obtained using stamp agar medium from inflammatory lesions of 29 adult patients with atopic dermatitis before and after a single photochemotherapy. Therapy was oral PUVA (30 mg 8-methoxypsoralen, 8MOP plus 5 J/cm2UVA), topical PUVA (0·3% 8MOP plus 200mJ/cm2UVA) or UVB (80mJ/cm2) irradiation. The number of S. aureus on the lesions was significantly reduced, even after a single treatment with all therapies. Reductions (mean± SD) were 69·3 ± 26.9%, 76·3 ± 31·3% and 83·8 ± 18·5%. respectively. Secondly, we investigated the effect of PUVA (0·001% 8MOP plus 10, 20, 30, 40, or 50 mJ/cm2UVA) and UVB (10, 30, 50, or 100 mJ/cm2) irradiation on the proliferation of S. aureus in vitro. PUVA and UVB treatment markedly inhibited the proliferation in a dose-dependent manner. These results seem to indicate the possibility that the antimicrobial effect of UV radiation contributes to successful photochemotherapy in patients with atopic dermatitis.
The use and efficacy of child restraint devices. The Tennessee experience, 1982 and 1983
Authors: M. D. Decker
Journal: JAMA (1984)

The Tennessee Child Passenger Protection Act, mandating the use of child restraint devices for children younger than 4 years, took effect in 1978. In the years 1978 through 1983, eighty-one children younger than 4 years died in Tennessee traffic accidents; only two were in child restraint devices. During this period, as child restraint device use rose from 8% to more than 30%, the number of deaths among children younger than 4 years declined more than 50%. Analysis of supplemental accident reports filed in investigations of motor vehicle accidents involving children younger than 4 years during 1982 and 1983 showed that child restraint devices are highly effective in preventing death and in preventing or reducing injury. Children not in child restraint devices were 11 times more likely to die in an accident than children in child restraint devices. Children traveling in the arms of an adult were exposed to a risk of injury or death comparable to that of children left entirely unrestrained. (<i>JAMA</i>1984;252:2571-2575)
Book Review
Journal: Psychotherapy and Psychosomatics (1953)

From the pen of the well-known French psychosomatic specialist Erich Stern, this work, w ritten in G erm an, presents a clear survey and discussion of American investigations in the field of psychosomatics.This alone would make the book an im portant acquisition for medical men in the German-speaking countries.Stern not only possesses a wide and profound knowledge of the literature; he also masters the art of presenting a sound and extremely readable, systematically arranged survey of it.The hook starts by explaining the signifi cance and essential nature of psychosomatic medicine and of the customary methods of investigation.Stern then discusses the more specialized knowledge concerning psychosomatic interrelations, i.e. physio-psychic interconnexions be tween the various organ-systems.He refers especially and in detail to his wellknown investigations into the psychosomatic interrelationship in cases of tu b er culosis, w here he adm its to be an adherent to the "non-specificity school" ; and the same applies to his experiences with dermatosis patients, where he hesitates to accentuate specificity, not only in respect of particular conflict situations, but also in respect of any particular personality structure.To personality character istics Stern attributes only a very general significance.An im portant point is, further, Stern's conception of the essential nature of psychosomatic affections, which he regards as identical with organ-neuroses, a viewpoint which we our selves, of the Leyden Psychosomatic Centre, also hold.Following a brief discussion of psychosomatic factors connected with senescence and death.Stern concludes his valuable work with a rather short chapter on therapeutic possibilities.H ere, he holds the same view's as most French psychosomatic specialists, namely that orthodox psychoanalysis is not absolutely necessary in the case of psychosomatic patients, a relatively super ficial therapy, guided by analytical insight, being adequate.By and large, an excellent acquisition for the investigator in the field of psychosomatics!
Falls and fractures in patients with Alzheimer-type dementia
Authors: D. M. Buchner
Journal: JAMA (1987)

The prevention of fall-related injuries in patients with Alzheimer-type dementia (ATD) is hampered by an incomplete understanding of their causes. We studied falls and fractures in 157 ATD patients, including 117 with three-year follow-up. Initially all but one patient could walk; 31% reported falls. During follow-up, 50% either fell or became unable to walk. The fracture rate during follow-up (69/1000/y) was more than three times the age- and sex-adjusted fracture rate in the general population. Features of both ATD and comorbid conditions contributed to the risk of falls and fractures. In particular, patients who experienced toxic reactions to drugs on entry into the study were more likely to report they had fallen prior to entry (odds ratio, 4.9; 95% confidence interval, 1.78 to 13.3), and patients who wandered were more likely to sustain fractures (odds ratio, 3.6; 95% confidence interval, 1.25 to 10.4) during the follow-up period, including hip fractures for which the odds ratio of 6.9 (95% confidence interval, 1.66 to 28.6) was unexpectedly high. Preventive measures may be possible, including controlling wandering, avoiding toxic reactions to drugs, and treating comorbid illnesses. (<i>JAMA</i>1987;257:1492-1495)
Methods of Suicide Among Persons Aged 10-19 Years—United States, 1992-2001
Journal: JAMA (2004)

In 2001, suicide was the third leading cause of death among persons aged 10-19 years. The most common method of suicide in this age group was by firearm (49%), followed by suffocation (mostly hanging) (38%) and poisoning (7%). During 1992-2001, although the overall suicide rate among persons aged 10-19 years declined from 6.2 to 4.6 per 100,000 population, methods of suicide changed substantially. To characterize trends in suicide methods among persons in this age group, CDC analyzed data for persons living in the United States during 1992-2001. This report summarizes the results of that analysis, which indicated a substantial decline in suicides by firearm and an increase in suicides by suffocation in persons aged 10-14 and 15-19 years. Beginning in 1997, among persons aged 10-14 years, suffocation surpassed firearms as the most common suicide method. The decline in firearm suicides combined with the increase in suicides by suffocation suggests that changes have occurred in suicidal behavior among youths during the preceding decade. Public health officials should develop intervention strategies that address the challenges posed by these changes, including programs that integrate monitoring systems, etiologic research, and comprehensive prevention activities.
Reply
Authors: C. T. Pease
Journal: British Journal of Dermatology (1988)

Journal Article Reply Get access C. T. Pease C. T. Pease Department of Immunology and Rheumatic Diseases, Charing Cross Hospital (Fulham), Fulham Palace Road, London W6 8RF, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 118, Issue 4, 1 April 1988, Pages 587–588, https://doi.org/10.1111/j.1365-2133.1988.tb02479.x Published: 01 April 1988
PLEURECTOMY FOR CONGENITAL HEART DISEASE
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AHA/ACCF/HRS Recommendations for the Standardization and Interpretation of the Electrocardiogram
Authors: Galen S. Wagner, Peter Macfarlane, Hein Wellens, Mark Josephson, Anton Gorgels, David M. Mirvis, Olle Pahlm, Borys Surawicz, Paul Kligfield, Rory Childers, Leonard S. Gettes
Journal: Journal of the American College of Cardiology (2009)
Infratemporal fossa foreign body
Authors: G. M. English
Journal: JAMA (1968)

Trismus is a common sequela of maxillofacial injuries. Foreign bodies are commonly associated with many injuries, however, they are very rare in the infratemporal fossa. In this case, there was fracture of the maxilla and an associated infratemporal foreign body which was rediolucent and undetected for a period of ten weeks. Removal of this foreign body resulted in immediate and complete resolution of the patient's symptom of trismus.
Massachusetts Medical Society
Authors: John Figgis Jewett
Journal: New England Journal of Medicine (1972)

COMMITTEE ON MATERNAL WELFARE EXTRAUTERINE PREGNANCYA 31-year-old para 1, pregnant again after 10 years, was seen because of vaginal spotting twice in 10 weeks and lower abdominal pain for several hours. She had a tense, tender abdomen, with tenderness in the cul-de-sac and on motion of the cervix; the uterus could not be outlined. The hemoglobin was 11 g per 100 ml, with a hematocrit of 31 per cent. The pulse was 80, and the blood pressure 120/78.On the next day, under spinal anesthesia, a mass consistent with gestation of 12 weeks was palpated as well as . . .
Endoluminal brushing of occluded long term parenteral nutrition catheters is associated with a reduced need for catheter replacement
Authors: M. Mcmahon, A. Teubner, J. Shaffer, S. Lal
Journal: Gut (2011)

<h3>Introduction</h3> Maintaining venous access is paramount to survival in patients on home parenteral nutrition(HPN),but central venous catheter(CVC) occlusion is a significant reason for CVC removal; this occurs largely due to lipid or fibrin precipitate, so a standard clearance protocol using ethanol, hydrochloric acid (HCl) and urokinase is well established.1 Endoluminal brushing has been used to diagnose CVC sepsis and resolve occluded haemodialysis CVCs.2 We aimed to evaluate the efficacy of endoluminal brushing of occluded HPN CVCs and whether the technique is associated with reduced need for CVC replacement. <h3>Methods</h3> Data on patient with occluded HPN CVCs (median duration of HPN 29 months) presenting to a National IFU over 7 years were collected prospectively. Endoluminal brushes were withdrawn in March 2006 in the UK due to manufacturing issues so patients were divided into 2 groups: Brushing Group (patients presenting from Dec 2003 to March 2006,all of whom underwent CVC brushing with ‘fibrin analysis system’ (FAS) endoluminal brushes) and Standard Group (patients presenting from April 2006-Sept 2010,who were managed with a standard protocol of urokinase &amp; ethanol flushing; 70% ethanol ± 5000 units urokinase was used in patients predominantly on a lipid regimen; HCl±urokinase was used for glucose/electrolyte regimens). Statistical analysis was performed with chi-squared. <h3>Results</h3> 68 episodes of line occlusion occurred in 44 patients (48% male; mean age 47) in the Brushing Group; of these,20 patients had undergone failed treatment with the standard occlusion protocol before brushing. Successful clearance was achieved in 36 patients after a median of 1 brushing (range 1–4); line replacement was required in the other 8 patients (18%) after a median of 1.5 brushing attempts(range 1–4).In patients in whom brushing had been successful, 15 patients9 lines reblocked after a median of 10 months(range 1–65). No complication related to brushing was recorded. 69 episodes of line occlusion occurred in 45 patients (52% male; mean age 50) in the Standard Group, with successful clearance achieved in 16 patients; line replacement was required in the other 29 patients (64%; p&lt;0.01 vs Brushing Group). In patients in whom the standard approach had been successful,8 patients9 lines reblocked after a median of 2.5 months(range 1–10). <h3>Conclusion</h3> This is the first study to demonstrate that FAS endoluminal brushing is safe and effective in clearing occlusions in HPN CVCs &amp; is associated with a significant reduction in the need for line replacement compared to standard techniques. If endoluminal brushes become available again in the UK, the technique should be evaluated in a prospective controlled study.
La VALEUR prophylactique DES rayons ultra-violets.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SAT0266 Obesity is Associated with Lower Probability of Achieving Sustained Minimal Disease Activity State Among Patients with Psoriatic Arthritis
Authors: L. Eder, A. Thavaneswaran, V. Chandran, R. Cook, D. D. Gladman
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> The prevalence of obesity among patients with psoriatic arthritis (PsA) is increased compared to the general population. Obese patients with PsA tend to respond less favorably to TNF alpha blockers compared to patients with normal weight. <h3>Objectives</h3> To investigate the association between obesity and outcome of the disease in patients with PsA by assessing if overweight and obese patients are less likely to achieve sustained minimal disease activity (MDA) state. <h3>Methods</h3> A cohort analysis of patients followed prospectively from 2003 to 2012 at a large PsA clinic was performed. Patients were scheduled to be followed at 6-12 month intervals according to a standard protocol. Demographic, clinical, laboratory and radiographic data were entered into a computerized database. Patients with a follow-up of less than 1 year were excluded. Body Mass Index (BMI) was calculated and patients categorized accordingly into the following groups: Normal (&lt;25), Overweight (25-30) and Obese (&gt;30). Sustained MDA was defined as fulfilling at least 5 out of 7 criteria as suggested by Coates et al [1] for at least 1 year. Proportional odds discrete time to event analysis was used to investigate the association between BMI category and the achievement of sustained MDA, adjusting for age, gender, disease duration, DMARD and TNF alpha blocker use. <h3>Results</h3> A total of 557 patients (58.7% males) were included in the study. Their mean age and disease duration at baseline were 48.6±13.1 and 11.5±10.4 years, respectively. 36.2% of the patients were classified as overweight and 35.4% were obese. Overall, 66.1% of the patients achieved sustained MDA. High HAQ and pain scores were the items that most frequently prevented patients from achieving MDA. Overweight and obese patients were older at baseline (p=0.04) and were older at onset of PsA (p=0.002) and psoriasis (p=0.002). They were also more likely to use NSAIDs (p=0.005) compared to patients with normal weight. A dose response association was found between obesity and the probability of achieving sustained MDA in the multivariate regression analysis. Patients in the higher BMI categories were less likely to achieve sustained MDA compared to patients in the lower BMI category (BMI 25-30: Odds Ratio (OR) 0.64 p=0.001, BMI&gt;30: OR 0.52 p&lt;0.0001) after adjusting for potential confounding variables. <h3>Conclusions</h3> The prevalence of obesity and overweight is high in patients with PsA. Patients who are overweight and obese are less likely to achieve sustained MDA compared to patients with normal weight. <h3>References</h3> Coates LC et al. Frequency, predictors, and prognosis of sustained minimal disease activity in an observational psoriatic arthritis cohort. Arthritis Care Res. 2010;62:970-6 <h3>Disclosure of Interest</h3> None Declared
The advice zone
Authors: James McCaul, Emma Jones, Mark Wilson, Evelyn Ong, Peter Skew, Nick Beeching
Journal: BMJ (2004)

Got a career or university related problem that needs answering? Can9t find the right person to point you in the right direction? Log on to the Advice Zone at www.bmjcareers.com/advicezone to post a question or to see if one of our experts has already solved your problem
ERRATA
Journal: Journal of Clinical Oncology (2015)

an error.In Figure 2, in the legend, C and D were incorrect.C was given as "Disease-free survival (n ϭ 585)" and D was given as "Overall survival (n ϭ 585)" but it should have been reversed.The legend should have read, (C) Overall survival (n ‫؍‬ 585).(D) Disease-free survival (n ‫؍‬ 585).
Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis
Authors: Kirsteen H. Maclean, Frank C. Dorsey, John L. Cleveland, Michael B. Kastan
Journal: Journal of Clinical Investigation (2008)

During the preparation of the manuscript, the definition of the error bars was inadvertently omitted.In all figures, error bars indicate SEM.
Statistical and Pathological Observations on Some Altered Conditions of the Liver
Authors: J. Black
Journal: BMJ (1846)

There is, perhaps, no organ in the human body which displays such varied appearances in bulk, weight, and colour, as does the liver, even outwardly; and assuredly there are none tbat, upon section, exhibit such special differences in colour, apparent arrangement of texture, and also in consistence, as this important organ does.These varieties are sometimes so dis- tinctly marked, that the inexperienced necrotomist may be led to suppose he has fallen upon somne new disease, and its consequent imuorbid alteration, on each