tbuckley/cabot-search huggingface dataset:
A NEW NONOPERATIVE TECHNIC FOR REMOVAL OF IMPACTED CALCULUS IN URETHRA
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Thymoma and Systemic Lupus Erythematosus in the Same Patient
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
OC-069 Rotational thromboelastometry in cirrhosis: hypercoagulable and hyperfibrinolytic
Authors: V Jairath, D Hall, P Harrison, S Stanworth, T Walsh, P Hayes, J Collier, M Murphy, E Barnes
Journal: Gut (2012)

<h3>Introduction</h3> Cirrhotics have complex acquired derangements of haemostasis. Routine coagulation tests suggest a hypocoagulable profile, resulting in frequent administration of blood components for prophylaxis and treatment of bleeding. Rotational thromboelastography (ROTEM<sup>®</sup>), unlike standard coagulation tests, provides a real-time measurement of clot formation, strength and stability in whole blood and may more accurately reflect in vivo coagulation. We aimed to (1) identify the key derangements in the haemostatic pathways in patients with cirrhosis; (2) determine the prevalence of overt hyperfibrinolysis and whether this could be improved with anti-fibrinolytics. <h3>Methods</h3> We used ROTEM<sup>®</sup> to investigate: (1) Clotting time (CT) and maximum clot firmness (MCF) in stable, non-bleeding cirrhotics compared to healthy volunteers; (2) The presence of overt hyperfibrinolysis and whether this could be reversed by spiking blood samples ex vivo with the antifibrinolytic aprotinin (APTEM test). Overt hyperfibrinolysis was defined by a maximum lysis (ML) of &gt;15% and by comparing the clot lysis index at 60 min between EXTEM and APTEM parameters. <h3>Results</h3> 106 adult cirrhotics and 28 healthy volunteers were enrolled after informed consent. Median EXTEM CT was shorter in cirrhotics than controls (51s vs 58s, p&lt;0.01) and the clotting time shortened as Child-Pugh score increased in severity (52s Child A, 49s, Child B, 47s Child C). In cirrhotics there was strong correlation between EXTEM MCF with both platelet count (r=0.801, p&lt;0.0001) and fibrinogen levels (r=0.653, p&lt;0.0001), as well as fibrinogen and FIBTEM MCF (r=0.641, p&lt;0.0001). 25% (26/106) of cirrhotics had evidence of overt hyperfibrinolysis. After spiking samples from cirrhotics with aprotinin, hyperfibrinolysis was completely reversed (ML&lt;15%) in 50% (13/26) cases and partially reversed in 50% (13/26) cases. There was a significant reduction in the median ML between EXTEM and APTEM clot profiles (13 vs 11, p&lt;0.001). D-dimer levels increased with increasing disease severity (Child A-894, Child B-1835, Child C-5281). <h3>Conclusion</h3> Cirrhotics have a hypercoagulable clotting time, despite prolonged PT, APTT and thrombocytopenia supporting the concept of re-balanced haemostasis. Use of ROTEM<sup>®</sup> may avoid unnecessary and potentially harmful transfusion of pro-coagulant blood components in cirrhotics. The high prevalence of overt hyperfibrinolysis in cirrhosis requires further elucidation and clinical studies to investigate the potential role of anti-fibrinolytics in the prophylaxis of variceal bleeding. <h3>Competing interests</h3> None declared.
ERNST HEINRICH WEBER (1795-1878) LEIPZIG PHYSIOLOGIST
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Trends in the Prevalence and Incidence of Self-Reported Diabetes Mellitus—United States, 1980-1994
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 18317: Impact of Pulmonary Valve Replacement on Right Ventricular Myocardial Deformation in Repaired Tetralogy of Fallot
Authors: Deane Yim, Luc Mertens, Mark Friedberg, Lars Grosse-Wortmann, Conall Morgan, Andreea Dragulescu
Journal: Circulation (2015)

Introduction: Pulmonary regurgitation is common following tetralogy of Fallot (TOF) repair and leads to progressive right ventricular (RV) dilatation and dysfunction. There is limited data on ventricular remodeling and adaption following surgical pulmonary valve replacement (PVR), especially beyond the short-term. Hypothesis: Our objective is to assess medium-term effects of PVR on right ventricular mechanics in patients with surgically repaired TOF. Methods: Speckle-tracking echocardiography was performed on pre-operative and post-operative echocardiograms in 50 patients with repaired TOF who underwent surgical PVR. RV global and segmental myocardial deformation parameters were assessed. Transthoracic studies 2.1±2.1 months pre-PVR, 2.23±0.61 months post-PVR (early follow-up) and 14.9±3.8 months post-PVR (medium-term follow-up) were analyzed. Results: The mean age at PVR was 12.6±3.3 years. Global RV longitudinal strain fell from -19.2%±2.7% to -16.8%±2.6% at early follow-up (p&lt;0.001) but increased by late follow-up to -21.9%±3.1% (p&lt;0.001). Basal segmental RV longitudinal strain showed a similar early reduction in strain followed by improvements late post-operatively (p&lt;0.001). Mid-segmental RV longitudinal strain improved by late post-operative follow-up (p=0.002), whereas apical segmental RV strain increased in the early post-operative period (p=0.004). There was a weak inverse correlation between pre-operative RV indexed end-diastolic volumes and RV mean longitudinal strain (R2=0.383). Conclusion: Although an early reduction in RV longitudinal strain occurs following PVR, the volume unloading effects of PVR has a significant effect on late RV remodelling as reflected by improvements in global RV longitudinal, basal and mid segmental strain late post-PVR. The effects of reversed remodelling of the RV may have important clinical implications towards determining the optimal timing of PVR in this subset of patients.
Cardiothoracic surgery
Authors: F. M. Lupinetti
Journal: JAMA (1990)

The internal mammary artery (IMA) remains firmly established as the conduit of choice for coronary artery revascularization procedures. Internal mammary artery grafts have better long-term patency than vein grafts and are associated with longer patient survival and a lower rate of reoperation. Furthermore, the IMA performs as well when used as a sequential or free graft as when it is grafted to a single coronary artery as an in situ graft. These excellent results have encouraged surgeons to perform bilateral IMA grafts. Recent studies have defined limitations on this technique and have demonstrated an increased frequency of complications when it is performed. Fiore et al<sup>1</sup>studied patients who were undergoing coronary revascularization with either single or double IMA grafts. At a mean follow-up of 14.4 years, the double IMA group had a significantly better freedom from recurrent angina and myocardial infarction. Reoperation rates were not different, and survival benefits
Parenteral Steroids Prevent Adrenal Collapse
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Seventh Annual Report of the State Board of Health of the State of Kansas.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Easing errors
Authors: Carol Cooper
Journal: The Lancet (2005)

Adverse events are distressing all round, so I did not expect this educational DVD from Johns Hopkins University's Bloomberg School of Public Health to make comfortable viewing. Long gone are the days when doctors could hope to bury their mistakes, or believed that saying sorry was tantamount to an admission of guilt. As the attorney on Removing Insult from Injury: Disclosing Adverse Events reminds us, apologising does not usually increase the risk of litigation. If anything, it can reduce it by defusing anger.
Clinical and laboratory correlates of Pneumocystis carinii pneumonia in children infected with HIV
Authors: E. Connor
Journal: JAMA (1991)

The case histories of 27 children with<i>Pneumocystis carinii</i>pneumonia (PCP) who were followed up in the AIDS Program at the Children's Hospital of New Jersey, Newark, are reviewed. The mean and median age at PCP diagnosis were 10.8 and 7.7 months, respectively. All of the children had other clinical evidence of infection with the human immunodeficiency virus that was documented prior to the diagnosis of PCP or found at the time of PCP diagnosis. Most patients who presented to the hospital were acutely ill, and complications of treatment occurred in 70%. Overall, 89% of the patients died and 70% survived for less than 6 months after diagnosis of PCP. Median survival after the diagnosis of PCP was only 2.0 months and the median life span of children with PCP was only 14.4 months. Only 40% of children with PCP had CD4 lymphocyte counts at or below the threshold for institution of PCP prophylaxis in adults of 200 × 106 cells/L (200 cells/mm3). (<i>JAMA</i>. 1991;265:1693-1697)
Tibial-shaft fractures in adults and children
Authors: T. C. Stanford
Journal: JAMA (1966)

Healing rates of various types of tibial-shaft fractures are compared as to type of treatment. Conservative management in adults is found to have certain advantages and certain limitations. In the case of closed tibial-shaft fractures, no advantage is shown for either open operative or closed treatment. The hazard of introducing infection is considered to be the single greatest deterrent to operative fixation of closed fractures. In this series, primary internal fixation of an open fracture is associated with a very real hazard of infection and with prolongation of the healing rate. Internal fixation of open tibial-shaft fractures should be reserved for those cases with minimal contamination and cases in which stability can be achieved with the least exposure of bone and the least quantity of metal implanted in the limb.
Evaluation of a new aerosolized steroid for asthma therapy: beclomethasone dipropionate (Vanceril inhaler)
Authors: J. C. Ballin
Journal: JAMA (1976)

Beclomethasone dipropionate, an esterified derivative of betamethasone, can be given in small doses in aerosol form to patients with severe asthma whose symptoms cannot be controlled with nonsteroidal agents (bronchodilators and cromolyn). Many asthmatic patients who previously required systemic steroids can be transferred to this safer anti-inflammatory agent. In usual doses, beclomethasone produces few, if any, systemic side effects. The only substantial reaction is Candida infections of the oropharynx and larynx. (<i>JAMA</i>236:2891-2893, 1976)
9. Cardiovascular Disease and Risk Management: <i>Standards of Medical Care in Diabetes—2018</i>
Journal: Diabetes Care (2017)

The American Diabetes Association (ADA) “Standards of Medical Care in Diabetes” includes ADA’s current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA Professional Practice Committee, a multidisciplinary expert committee, are responsible for updating the Standards of Care annually, or more frequently as warranted. For a detailed description of ADA standards, statements, and reports, as well as the evidence-grading system for ADA’s clinical practice recommendations, please refer to the Standards of Care Introduction. Readers who wish to comment on the Standards of Care are invited to do so at professional.diabetes.org/SOC.
Recent Events of Special Interest to Medical Education
Authors: Richard L. Egan
Journal: JAMA (1986)

The EDUCATION ISSUE of<i>JAMA</i>traditionally has included a review of events that have had an impact on medical education. Over the past several years, the events reviewed were those that sustained or improved the quality of medical education. At this point in the history of US medical education, there are several factors at work that separately and collectively are producing trends that threaten the clinical base, which has become an integral part of our system of medical education. The public concern for cost containment in health care has led to the operation of some hospitals by professional management firms and to other hospitals becoming investor-owned with a vertically integrated system of health care delivery. The corporate search for less expensive health insurance for employees has produced "competition" for patients and the formation of health maintenance organizations (HMOs) and preferred provider organizations (PPOs). Cost containment at the federal level has
24-month follow-up from the Patient’s Anastrozole Compliance to Therapy (PACT) program evaluating the influence of a standardized information service on compliance in postmenopausal women with early breast cancer.
Authors: H. Lück, P. Hadji, N. Harbeck, C. Jackisch, M. Blettner, M. Glados, J. Terhaag, R. Hackenberg, T. Goehler, S. Zaun, A. Rexrodt von Fircks, R. Kreienberg
Journal: Journal of Clinical Oncology (2011)

526
Costly Errors
Authors: Thomas P. Duffy
Journal: New England Journal of Medicine (1995)

A 74-year-old woman was referred to a hematologist for a transfusion-dependent anemia that had been present for seven months. The anemia was initially recognized after a fall that caused fractures of several ribs and a lumbar vertebra. Prednisone (40 mg twice daily) had been administered after the report of a positive Coombs' test, but it had not corrected the anemia. The patient required two to three units of blood each week to maintain her hematocrit between 20 and 25 percent.This is a patient with a severe Coombs'-positive anemia that has proved refractory to high doses of prednisone. . . .
Erratum
Authors: Donald Fox, Subbarao Kala, W Hamilton, Jerry Johnson, James O'callaghan
Journal: Environmental Health Perspectives (2008)

BACKGROUND: Postnatal lead exposure in children and animals produces alterations in the visual system primarily characterized by decreases in the rod-mediated (scotopic) electroretinogram (ERG) amplitude (subnormality).In contrast, low-level gestational Pb exposure (GLE) increases the amplitude of scotopic ERGs in children (supernormality).OBJECTIVES: The goal of this study was to establish a rat model of human equivalent GLE and to determine dose-response effects on scotopic ERGs and on retinal morphology, biochemistry, and dopamine metabolism in adult offspring.METHODS: We exposed female Long-Evans hooded rats to water containing 0, 27 (low), 55 (moderate), or 109 (high) ppm of Pb beginning 2 weeks before mating, throughout gestation, and until postnatal day (PND) 10.We measured maternal and litter indices, blood Pb concentrations (BPb), retinal Pb concentrations, zinc concentrations, and body weights.On PND90, we performed the retinal experiments.RESULTS: Peak BPb concentrations were < 1, 12, 24, and 46 µg/dL in control, low-, moderate-and high-level GLE groups, respectively, at PNDs 0-10.ERG supernormality and an increased rod photoreceptor and rod bipolar cell neurogenesis occurred with low-and moderate-level GLE.In contrast, high-level GLE produced ERG subnormality, rod cell loss, and decreased retinal Zn levels.GLE produced dose-dependent decreases in dopamine and its utilization.CONCLUSIONS: Low-and moderate-level GLE produced persistent scotopic ERG supernormality due to an increased neurogenesis of cells in the rod signaling pathway and/or decreased dopamine utilization, whereas high-level GLE produced rod-selective toxicity characterized by ERG subnormality.The ERG is a differential and noninvasive biomarker of GLE.The inverted U-shaped dose-response curves reveal the sensitivity and vulnerability of the developing retina to GLE.
Morbidity and mortality after ambulatory surgery
Authors: M. Feldman
Journal: JAMA (1994)

<h3>To the Editor.</h3> —Dr Warner and colleagues<sup>1</sup>present an excellent study to demonstrate the safety of ambulatory surgery and anesthesia. I would disagree, however, with the "well-known observation that patients scheduled for elective surgical procedures are usually healthier than the general population." In their study, 24% (10 867/45 090) of procedures were performed on patients of American Society of Anesthesiologists physical status (ASA PS) classification 3, with "severe systemic disease, definite functional limitation." I would be surprised if this sample of the population was healthier than the age-adjusted general population in the area. Perhaps some data are available to compare the prevalence of hypertension and diabetes in the study patients with the general population. According to Orkin and Gold,<sup>2</sup>"[W]hen there was a need to gain credibility with both the medical community and the insurance industry, only the healthiest were deemed appropriate candidates. With the passage of time
EFFECTS OF ADVANCED HEART FAILURE TREATMENT ON SYMPTOMS IN PATIENTS WITH A SYSTEMIC RIGHT VENTRICLE
Authors: Mikael G. Dellborg, Joel Heimdahl, Kristofer Skoglund, Bengt Johansson, Christina Christersson, Eva Mattsson, Peter Eriksson, Ulf Thilen
Journal: Journal of the American College of Cardiology (2018)