tbuckley/cabot-search huggingface dataset:
Bone mass in lifetime tennis athletes
Authors: A. L. Huddleston
Journal: JAMA (1980)

The effects of physical exercise on the status of bone mineralization for a population of lifetime athletes were investigated. The bone mineral content of the radii of experienced male tennis players was measured. The bone mass of the radius of the playing arm (mean, 1.37 g/cm) was greater than that of the nonplaying arm (mean, 1.23 g/cm) in all but one person. The results were compared with data for a nonathletic (normal) population. The quantity of bone mineral present in the playing arms of the athletic population was greater than that of the dominant arms of nonathletes, which suggests that playing tennis during a lifetime may produce a localized increase in bone mineralization that is greater than that found in non-athletes. (<i>JAMA</i>244:1107-1109, 1980)
&lt;TITLE&gt;The importance of a Pap test&lt;/TITLE&gt;
Journal: JAMA (1999)

The importance of a Pap testThe JAMA Patient Page is a public service of JAMA and the AMA.The information and recommendations appearing on this page are appropriate in most instances; but they are not a substitute for medical diagnosis.For specific information concerning your personal medical condition, JAMA and AMA suggest that you consult your physician.
Asian Regional Conference on The International Organization for Medical Physics
Journal: JNCI Journal of the National Cancer Institute (1986)

Journal Article Asian Regional Conference on The International Organization for Medical Physics Get access JNCI: Journal of the National Cancer Institute, Volume 77, Issue 2, August 1986, Page 594, https://doi.org/10.1093/jnci/77.2.594-c Published: 01 August 1986
Lectures on Tropical Diseases, Being the Lane Lectures for 1905, Delivered at Cooper Medical College, San Francisco, U. S. A., August, 1905, by P. Manson.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
IL-12 is required for differentiation of pathogenic CD8+ T cell effectors that cause myocarditis
Authors: Nir Grabie, Michael W. Delfs, Jason R. Westrich, Victoria A. Love, George Stavrakis, Ferhaan Ahmad, Christine E. Seidman, Jonathan G. Seidman, Andrew H. Lichtman
Journal: Journal of Clinical Investigation (2003)

Cardiac antigen–specific CD8+ T cells are involved in the autoimmune component of human myocarditis. Here, we studied the differentiation and migration of pathogenic CD8+ T cell effector cells in a new mouse model of autoimmune myocarditis. A transgenic mouse line was derived that expresses cardiac myocyte restricted membrane-bound ovalbumin (CMy-mOva). The endogenous adaptive immune system of CMy-mOva mice displays tolerance to ovalbumin. Adoptive transfer of naive CD8+ T cells from the ovalbumin-specific T cell receptor–transgenic (TCR-transgenic) OT-I strain induces myocarditis in CMy-mOva mice only after subsequent inoculation with ovalbumin-expressing vesicular stomatitis virus (VSV-Ova). OT-I effector T cells derived in vitro in the presence or absence of IL-12 were adoptively transferred into CMy-mOva mice, and the consequences were compared. Although IL-12 was not required for the generation of cytolytic and IFN-γ–producing effector T cells, only effectors primed in the presence of IL-12 infiltrated CMy-mOva hearts in significant numbers, causing lethal myocarditis. Furthermore, analysis of OT-I effectors collected from a mediastinal draining lymph node indicated that only effectors primed in vitro in the presence of IL-12 proliferated in vivo. These data demonstrate the importance of IL-12 in the differentiation of pathogenic CD8+ T cells that can cause myocarditis.
Problem Doctors: Is There a System-Level Solution?
Authors: Lucian L. Leape, John A. Fromson
Journal: Annals of Internal Medicine (2006)

Letters6 June 2006Problem Doctors: Is There a System-Level Solution?Lucian L. Leape, MD and John A. Fromson, MDLucian L. Leape, MDFrom the Harvard School of Public Health, Boston, MA 02215, and Metro West Medical Center, Natick, MA 01760. and John A. Fromson, MDFrom the Harvard School of Public Health, Boston, MA 02215, and Metro West Medical Center, Natick, MA 01760.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-144-11-200606060-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We agree with Dr. Kuhn that much more attention needs to be paid to assessing medical students and residents for their suitability and fitness to practice medicine, and that failure to do so is a breach of the fiduciary responsibility of schools and hospitals. These are issues that the Association of American Medical Colleges and specialty boards should address.However, Dr. Kuhn's dismissal of the need for additional testing is diametrically opposed to every specialty board's strong (and, we think, laudable) initiative to develop much more rigorous and effective assessment of physician performance. Although we are sensitive to ... Author, Article, and Disclosure InformationAuthors: Lucian L. Leape, MD; John A. Fromson, MDAffiliations: From the Harvard School of Public Health, Boston, MA 02215, and Metro West Medical Center, Natick, MA 01760.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoProblem Doctors: Is There a System-Level Solution? Lucian L. Leape and John A. Fromson Problem Doctors: Is There a System-Level Solution? Duncan M. Kuhn Problem Doctors: Is There a System-Level Solution? Mark S. Gold and Kimberly Frost-Pineda Problem Doctors: Is There a System-Level Solution? Martin T. Donohoe Problem Doctors: Is There a System-Level Solution? David R. Gifford , Robert S. Crausman , and Bruce W. Mcintyre Metrics Cited bySurgeons in Difficulty: An Exploration of Differences in Assistance-Seeking Behaviors between Male and Female SurgeonsDISRUPTIVE BEHAVIOUR AMONGST DOCTORS, MYTH OR REALITY?The creation of risk‐related information 6 June 2006Volume 144, Issue 11Page: 863KeywordsConflicts of interestDrug policyDrugsHospital medicineHospitalsRural areas ePublished: 6 June 2006 Issue Published: 6 June 2006 Copyright & PermissionsCopyright © 2006 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Multiple Stages in Radiation Carcinogenesis of Rat Skin
Authors: Fredric J. Burns, Roy E. Albert, Seymour J. Garte
Journal: Environmental Health Perspectives (1989)

Epithelial cell cancers are induced in rat skin by ionizing radiation in a manner that is consistent with the dual action (i.e., two alterations) hypothesis of radiation effects on DNA. This hypothesis states simply that two initial alterations, presumably in the DNA, are necessary to start a normal cell on the pathway to cancer. The initial radiation-induced alteration in the DNA is repairable as indicated by the reduction in tumor incidence with increasing time between dose fractions; the repair halftime is estimated to be 3.0 +/- 1.0 hr. Theoretical predictions of a specific dependence of tumor incidence on linear energy transfer (LET) have been verified experimentally for two specific LET values. However, the theoretical formulation provides no guidance regarding the observed reduction in the carcinogenic action of radiation with age at the time of exposure. Analysis of the tumor DNA for oncogene activation indicated k-ras and c-myc oncogenes were activated in highly anaplastic rat skin cancers, whereas only one of these oncogenes, usually c-myc, was activated in comparatively benign basal cell carcinomas and in squamous cell carcinomas.
Control of methadone dosage by patients
Authors: A. Goldstein
Journal: JAMA (1975)

Patients in a methadone clinic were given knowledge and control of their own dosages. Dosages could be changed by 5 mg/week, but if more than 50 mg was used, no take-home privileges were allowed. The maximum dosage permitted was 120 mg. Plasma methadone levels were determined for some patients. The result of the study was that there was little dosage change, with the median dosage increasing from 40 to 50 mg at the end of six months. A small group of patients did raise their dosages systematically, and these patients tended to decrease illicit opiate use. There was no indication that these patients had abnormally low plasma methadone levels. At the end of six months, patients and staff overwhelmingly preferred an open-dose self-adjustment system over the usual procedure of dosage management by professional staff and dosage changes achieved by negotiation. (<i>JAMA</i>234:734-737, 1975)
Tufted angioma
Authors: E. Wilson Jones, M. Orkin
Journal: British Journal of Dermatology (1987)

Twenty patients (11 female, nine male) are described, with unusual, slowly progressive angiomas which usually arose on the neck and upper trunk in young patients. Histologically these angiomas were characterized by small circumscribed angiomatous tufts and lobules scattered in the dermis, hence the suggested title of ‘tufted angioma’. Half the angiomas arose in the first 5 years of life with only three of the lesions present at birth. However, in three patients the onset was after the age of 40. The lesions were predominantly macular, but some showed superficial papules or a deep‐seated nodular component. Some of the lesions were tender on palpation. Most lesions slowly extended so that eventually a large part of the trunk and neck was affected in some patients. Despite progression, the course was benign and malignant change has not been reported. Histologically, tufted angiomas show some similarity to the cellular angiomas of strawberry naevi, but the angiomatous lobules are much larger and more deeply situated in the latter. A panel of cell marker studies (Factor VIII‐related antigen, the lectin UEA‐I, and monoclonal antibodies EN4 and PAL‐E) indicated the main constituent cells to be endothelial cells. Familiarity with this acquired angiomatous condition in young persons should prevent confusion with AIDS‐related Kaposi's sarcoma and other malignant vascular tumours.
Amer J of Digestive Diseases, New York
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MEDICINE AND THE WAR
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Estimation of thyroid function by timing the arterial sounds
Authors: D. Rodbard
Journal: JAMA (1967)

The timing of the Korotkoff arterial sounds with reference to the electrocardiogram provides an objective index of thyroid function which is precise, accurate, rapid, innocuous, inexpensive, and independent of iodine metabolism. QK<sub>d</sub>is the interval between the QRS and the onset of Korotkoff sounds at diastolic pressure. The QK<sub>d</sub>value in 80 euthyroid subjects had a normal range of 186 to 235 msec. Ten patients with hypothyroidism had QK<sub>d</sub>values ranging from 230 to 320 msec.
Computer-Assisted Mechanistic Structure-Activity Studies: Application to Diverse Classes of Chemical Carcinogens
Authors: Gilda H. Loew, M. Poulsen, E. Kirkjian, J. Ferrell, B. S. Sudhindra, M. Rebagliati
Journal: Environmental Health Perspectives (1985)

In the first part of this paper we have indicated how the techniques and capabilities of theoretical chemistry, together with experimental results, can be used in a mechanistic approach to structure-activity studies of toxicity. In the second part, we have illustrated how this computer-assisted approach has been used to identify and calculate causally related molecular indicators of relative carcinogenic activity in five classes of chemical carcinogens: polycyclic aromatic hydrocarbons and their methyl derivatives, aromatic amines, chloroethanes, chloroalkenes and dialkyl nitrosamines. In each class of chemicals studied, candidate molecular indicators have been identified that could be useful in predictive screening of unknown compounds. In addition, further insights into some mechanistic aspects of chemical carcinogenesis have been obtained. Finally, experiments have been suggested to both verify the usefulness of the indicators and test their mechanistic implications.
S34 Effect of 8 and 12 weeks’ once-daily tiotropium and olodaterol, alone and combined with exercise training, on exercise endurance during walking in patients with copd
Journal: Thorax (2016)

AbstractT Troosters has received grants from Innovative Medicines Initiative Joint Undertaking and speaker fees from Boehringer Ingelheim and GlaxoSmithKline.J Bourbeau has received grants from the Canadian Institute of Health Research R&D collaborative programme (AstraZeneca, Boehringer Ingelheim, GlaxoSmithKline, Merck, Nycomed, Novartis), Canadian Respiratory Research Network, Respiratory Health Network of the FRQS and Research Institute of the MUHC, and an educational grant from GlaxoSmithKline.F Maltais has received grants from Boehringer Ingelheim, GlaxoSmithKline, AstraZeneca, Nycomed and Pfizer, personal fees from Boehringer Ingelheim, GlaxoSmithKline and Novartis, and other financial support from GlaxoSmithKline.N Leidy is employed by Evidera, a health-care research firm that provides consulting and other research services to pharmaceutical and other organisations including the study sponsor.D Erzen, D De Sousa, L Korducki and A Hamilton are employees of Boehringer Ingelheim Pharma GmbH & Co. KG.KL Lavoie reports personal fees from Boehringer Ingelheim for personnel training as well as a grant from AbbVie and personal fees from Bayer, Janssen, Novarits, AbbVie, Mundipharma and Almirall.W Janssens has no conflict of interest to report.
Evaluation of Idoxuridine (IDU)
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Interventional Pulmonology
Authors: Luis M. Seijo, Daniel H. Sterman
Journal: New England Journal of Medicine (2001)

Interventional pulmonology is a new field within pulmonary medicine focused on the use of advanced bronchoscopic and pleuroscopic techniques for the treatment of a spectrum of thoracic disorders ranging from tracheobronchial stenosis to pleural effusions associated with malignant tumors.14 Techniques Used in Interventional PulmonologyRigid Bronchoscopic Debulking or Balloon DilationTherapeutic use of bronchoscopy began over 100 years ago with the development of rigid bronchoscopes. These instruments have beveled tips, which are ideal for coring through large tumors in the airways and for dilating strictures, and they have large internal diameters, which facilitate débridement of tumors, evacuation of clots, . . .
THYMOPHYSIN
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The quetiapine question: management strategies for drug-drug interactions with antipsychotics and direct acting antivirals; a multicentre review
Authors: Katherine Davidson, Alison Boyle, Stephen Barclay, Elspeth Boxall, Cecilia Fleming, Peter Gossman, Janice McAvennie, Elaine Reilly, Elaine Sheridan, Andrew Sommerville, Fiona Marra
Journal: Journal of Hepatology (2020)
Thrombocythemia (Thrombocytosis)
Authors: H. Clark Hoagland
Journal: JAMA (1976)

IN MANY of the myeloproliferative syndromes, such as polycythemia vera, primary hemorrhagic thrombocythemia, chronic granulocytic leukemia, and agnogenic myeloid metaplasia, platelet counts may be in excess of 1,000,000/cu mm. This is especially true of primary hemorrhagic thrombocythemia and agnogenic myeloid metaplasia when the spleen has been removed.<sup>1</sup>Other conditions known to be associated with thrombocytosis, such as malignancy, iron deficiency anemia, and chronic inflammatory diseases (eg, rheumatoid arthritis or collagen disorders), are less likely to produce platelet counts in excess of 1 million. Even a patient who has had a splenectomy for other reasons will rarely have platelet counts above 1 million. Transient increases in platelets seen in the ten-day postoperative period do not appear to increase morbidity. In the myeloproliferative syndromes, platelet counts in excess of 1 million are frequently associated with thrombotic episodes and hemorrhagic manifestations. Thrombosis tends to involve the large vessels, such as the mesenteric