tbuckley/cabot-search huggingface dataset:
Chronic insomnia provokes more prescriptions than diagnoses
Authors: Q. R. Regestein
Journal: JAMA (1977)

CHRONIC insomnia, like most symptoms, arises from many causes but, unlike most symptoms, attracts little diagnostic interest. Often, on complaining of sleeplessness, a patient promptly receives a prescription for hypnotics. Once regular use of hypnotics begins, giving them up becomes arduous. Regular use of hypnotics might be more reasonable were they more than temporarily effective. Unfortunately, however, chronic hypnotic use does not get the patient to sleep any faster,<sup>1</sup>but rather increases nightly awakenings, abolishes deep sleep,<sup>2</sup>and continues to affect sleep patterns for five weeks after drug withdrawal.<sup>3</sup>The ready drug prescriptions available, it seems, have not only led to a scourge of drug habituation, but may well have lessened the quality of sleep obtained by insomniac patients. Additionally, it has bolstered the unrealistic notion that one ought first to resort to drugs to alleviate chronic insomnia. The patient relying on hypnotics is often left with
"NECROPSIES AND MEDICAL PROGRESS"
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MEDICAL EDUCATION—PROGRESS OF TWENTY-THREE YEARS
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Discussion on “A randomized clinical trial of ultrasound-guided infra-clavicular cannulation of the subclavian vein in cardiac surgical patients: short-axis versus long-axis approach”
Authors: Gabriel Preda, Naïke Bigé, Michael Bonsey, Jérémie Joffre, Hafid Ait-Oufella, Eric Maury, Antonella Vezzani, Tullio Manca, Claudia Brusasco, Gregorio Santori, Luca Cantadori, Andrea Ramelli, Gianluca Gonzi, Francesco Nicolini, Tiziano Gherli, Francesco Corradi
Journal: Intensive Care Medicine (2017)
Reduced Folate Carrier Expression in Acute Lymphoblastic Leukemia: A Mechanism for Ploidy but not Lineage Differences in Methotrexate Accumulation
Authors: Vladimir M. Belkov, Eugene Y. Krynetski, John D. Schuetz, Yuri Yanishevski, Eric Masson, Susan Mathew, Susana Raimondi, Ching-Hon Pui, Mary V. Relling, William E. Evans
Journal: Blood (1999)
Erratum: Whole-genome sequencing of chronic lymphocytic leukaemia reveals distinct differences in the mutational landscape between IgHVmut and IgHVunmut subgroups
Authors: A Burns, R Alsolami, J Becq, B Stamatopoulos, A Timbs, D Bruce, P Robbe, D Vavoulis, R Clifford, M Cabes, H Dreau, J Taylor, S J L Knight, R Mansson, D Bentley, R Beekman, J I Martín-Subero, E Campo, R S Houlston, K E Ridout, A Schuh
Journal: Leukemia (2017)

Correction to: Leukemia (2018) 32, 332–342; doi: 10.1038/leu.2017.177; published online 27 June 2017 Since the publication of this article, the authors have identified an omission in their paper, namely that two contributing authors were not included in the author list: B Stamatopoulos1, R Clifford2
Lead Exchange in Teeth and Bone: A Pilot Study Using Stable Lead Isotopes
Authors: Brian L. Gulson, Barrie R. Gillings
Journal: Environmental Health Perspectives (1997)

Stable lead isop and le tio wem enameld e ie of nent (n = 37) and dedduous teeth ( 1 14) fom 47 Eu ii o Ausia to deter- mine whether lead nge occr in teeth and how itreates to lead e in bone.Enamel exhibits no of i Eure lead withl f the As a et 4||+t~~~~~~~~~~~~~~~~~~~.. ......exen Of'.contrast, detn edecagswt utainla oteetn f-%prya.In one sub-
ECUADOR
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bilateral Renal-Vein Thrombosis and the Nephrotic Syndrome in Adults
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Quality assessment. Moving from theory to practice
Authors: D. S. O'Leary
Journal: JAMA (1988)

Throughout the era of modern medicine, physicians have constantly risen to the challenge of resolving difficult problems. The process of resolution has provided both intellectual stimulation and the fundamental satisfaction of improving the human condition. Today, medicine faces a more complex challenge, the challenge to engage in meaningful selfexamination. In this issue of<i>JAMA</i>, Avedis Donabedian,<sup>1</sup>widely recognized for his formulation of quality assessment, sets forth in lucid detail the formidable task now facing clinical medicine. Despite exhortations for self-examination from the physician community since early in this century, what we know and have done about quality assessment to date is remarkably little. Students of quality assessment will find the Donabedian construct to be both provocative and useful. So too should practicing physicians, as we all begin to grapple with the convolutions of a different kind of science. This, of course, is not simply a scientific puzzle. The quality
Journal of Virology, Baltimore
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Opacification of the Small Bowel with Intravenously Administered Contrast Medium
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dying
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Kidney transplant pioneer John P. Merrill drowns
Authors: P. Gunby
Journal: JAMA (1984)

John P. Merrill, MD, whose landmark 1956 report of human kidney transplantation is reprinted in this issue (pp 2566-2571), drowned April 4 in a dockside accident while vacationing in the Commonwealth of the Bahamas. He spent his entire career at Harvard Medical School, Boston, from which he graduated in 1942 and where he was emeritus professor of medicine, and at the Brigham and Women's Hospital, where he took part in the first successful kidney transplant surgery nearly 30 years ago and where after World War II, he helped to build an artificial kidney unit. During that war, as a (then) Army Air Corps major, he served as flight surgeon to the aircrew of the B-29 bomber<i>Enola Gay</i>, who dropped the first atomic bomb on (Hiroshima) Japan. After the war, he returned to his native New England (he was born in Hartford, Conn, in 1917; attended St George's School, Newport,
This is a general question: is there much demand for experienced general practitioners in the English health system?
Authors: Anne Hastie
Journal: BMJ (2005)

Have a career or related problem that needs answering? Can9t find the right person to point you in the right direction? Log on to the Advice Zone for reliable medical careers advice. You can post a question or see if one of our 300 advisers has already answered a similar question. Here is a selection of questions and answers posted on the site. <b>www.bmjcareers.com/advicezone</b>
Bronchodilator aerosol. Comparison of administration methods
Authors: T. H. Smelzer
Journal: JAMA (1973)

A simple hand-held device was altered to provide isoproterenol hydrochloride via either powered nebulization or intermittent positive pressure breathing (IPPB). Sixteen patients with stable chronic obstructive airway disease were studied in a random alternate sequence on two successive days. Approximately 0.8 ml of 1:400 solution of isoproterenol hydrochloride was delivered to the patient each time either method was used. Ventilatory dynamics and arterial blood gases were measured before and after each use of the device. Sequential changes in forced vital capacity and forced expiratory volume in one second were remarkably similar no matter which method was used. No conclusions could be drawn from the changes in arterial pH and gas pressures. Based on functional improvement in patients with stable chronic obstructive airway disease, the therapeutic benefit from isoproterenol administered by IPPB was not significantly different from that observed after otherwise identical treatment with a simple powered nebulizer.
Abstract 864: Mutant IDH1 is essential for chondrosarcoma growth
Authors: Luyuan Li, Xiaoyu Hu, Josiane E. Eid, Joanna DeSalvo, Jonathan C. Trent
Journal: Cancer Research (2019)

Abstract Chondrosarcomas are malignant bone tumors that produce cartilaginous matrix. Mutations in isocitrate dehydrogenase enzymes (IDH1/2) were recently described in several cancers, including chondrosarcomas. IDH mutations detected in human cancers invariably are heterozygous missense substitutions. These mutations lead to the inability of IDH to convert isocitrate into α-ketoglutarate (α-KG). Instead, α-KG is reduced into 2-hydroxyglutarate (D-2HG), an oncometabolite. Due to the structural similarity between D-2HG and α-KG, it has been reported that high levels of D-2HG competitively inhibit α-KG-dependent dioxygenases such as TET, JHDM and PHD enzymes, thus contributing to tumorigenesis. We sought to determine the role of IDH1 mutations in the tumorigenesis of human chondrosarcomas by inactivating mutant IDH1 using pharmacological and genetic approaches. In our study, we employed two human chondrosarcoma cell lines, JJ012 and HT1080, that carry endogenous IDH1 mutations. IDH mutation analysis was performed by PCR-based DNA sequencing, and D-2HG levels were measured by tandem mass spectrometry. Mutant IDH1 was knocked down via siRNA and knocked out via CRISPR/Cas9. We analyzed the effect of mutant IDH1 on chondrosarcoma growth in murine xenograft models. We found that knockdown of mutant IDH1 via siRNA significantly reduced D-2HG production in chondrosarcoma cells. In addition, mutant IDH1 knockdown dramatically inhibited colony formation in the sarcoma cells. Consistently, genetic knockout of mutant IDH1 almost completely depleted D-2HG production and significantly inhibited colony formation in the chondrosarcoma cells. To assess the significance of these results in vivo, we implanted the mutant IDH1- knockout cells in nude mice and studied their capacity for tumor initiation and growth. In these models, we observed that loss of mutant IDH1 led to a marked attenuation of chondrosarcoma formation. Our findings clearly demonstrate that mutant IDH1 plays a vital role in chondrosarcoma tumor formation. By investigating the role of IDH mutations in the pathogenesis of chondrosarcomas, we aim to uncover the potential therapeutic targets against this aggressive cancer. Citation Format: Luyuan Li, Xiaoyu Hu, Josiane E. Eid, Joanna DeSalvo, Jonathan C. Trent. Mutant IDH1 is essential for chondrosarcoma growth [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 864.
'Poe-phyria,' Madness, and The Fall of the House of Usher
Authors: Choong R. Kim
Journal: JAMA (1989)

<h3>To the Editor.—</h3> Many explanations for the malady that affected Roderick and Madeline Usher in Edgar Allan Poe's<i>The Fall of the House of Usher</i><sup>1</sup>have been proposed, mostly psychiatric in nature.<sup>2</sup>One explanation for their affliction that has not been entertained is porphyria. Poe described an "acute bodily illness" and a "mental disorder" with intermittent exacerbations consistent with porphyria in Roderick Usher, who suffered from a familial disorder that involved his appearance, behavior, and sensory and motor function. Most porphyrias are transmitted in an autosomal-dominant fashion. Roderick Usher, his twin sister Madeline, and other members of the Usher family were afflicted by a familial disorder—"a constitutional and a family evil." Hypertrichosis and hirsutism, seen in some of the porphyrias, are described in the physical appearance of Roderick Usher: "Hair of a more than web-like softness and tenuity... above the regions of the temple... the silken hair... to
NOISES AND THEIR SUPPRESSION.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Activated Ask1-MKK4-p38MAPK/JNK Stress Signaling Pathway in Human Omental Fat Tissue May Link Macrophage Infiltration to Whole-Body Insulin Sensitivity
Authors: Matthias Blüher, Nava Bashan, Iris Shai, Ilana Harman-Boehm, Tanya Tarnovscki, Eliezer Avinaoch, Michael Stumvoll, Arne Dietrich, Nora Klöting, Assaf Rudich
Journal: Endocrine Reviews (2009)
Chiropractic
Authors: Daniel J. Fink
Journal: Annals of Internal Medicine (2002)

Letters15 October 2002ChiropracticDaniel J. Fink, MDDaniel J. Fink, MDLos Angeles, CA 90035Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-137-8-200210150-00026 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:After reading the article by Meeker and Haldeman (1), I have the following questions for them. First, where is the “basic science” of chiropractic? In a day and age of detailed neuroimaging by high-resolution computed tomography and magnetic resonance imaging, of neurophysiology studies and evoked potentials and electromyography, why has no one been able to demonstrate subluxations and their effects, on which chiropractic is based? Second, why doesn't chiropractic limit itself to spinal manipulation and back pain, for which there appears to be some evidence of benefit, instead of extending its reach to megavitamins, colonic irrigation, and ...Reference1. Meeker WC, Haldeman S. Chiropractic: a profession at the crossroads of mainstream and alternative medicine. Ann Intern Med. 2002;136:216-27. [PMID: 11827498] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Los Angeles, CA 90035 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoChiropractic: A Profession at the Crossroads of Mainstream and Alternative Medicine William C. Meeker and Scott Haldeman Chiropractic Ludmil A. Chotkowski Chiropractic William C. Meeker and Scott Haldeman Chiropractic Edzard Ernst Chiropractic Ronald L. Fredrickson Metrics 15 October 2002Volume 137, Issue 8Page: 701KeywordsChiropracticEmphysemaEvoked potentialsLower back painMagnetic resonance imagingMenopauseNeuroimagingNeurophysiologyPsoriasisSpine ePublished: 15 October 2002 Issue Published: 15 October 2002 CopyrightCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...