tbuckley/cabot-search huggingface dataset:
Distinct Enzymatic Responses in Mice Exposed to a Range of Low Doses of Ozone
Authors: T. S. Veninga, J. Wagenaar, W. Lemstra
Journal: Environmental Health Perspectives (1981)

Short-term exposure of mice to low O3 doses, as defined by the product of concentration and exposure time (ct), was observed to induce alterations in two enzyme systems: first, that leading to changes in hepatic reduced ascorbic acid (RAA) content, and second to changes in plasma creatine phosphokinase (CPK) activity. RAA alterations were noticed immediately, 30 min and 120 min after termination of the exposure period, whereas CPK showed alterations immediately and 15 min after termination of the exposure. Later determinations, i.e., 24 hr after O3 exposure for RAA and 30 min after 03 exposure for CPK, revealed no significant differences when compared to control animals. Although differences in sensitivity existed, the dose response curves for both systems were more or less similar, showing a short decrease for the initial very low O3 doses, followed by a profound rise and a gradual decrease to control levels for subsequent ct doses. Exceptions were the 30 min curve for RAA and the immediate curve for CPK in so far as that both showed an additional depression. Neither plasma histamine nor plasma lactic acid dehydrogenase (LDH3) were observed to be altered by the range of O3 doses employed. These findings were explained on the basis of adaptation of the organism to a potentially noxious O3 stimulus by enhanced metabolic processes: a weak stimulus leading to only a small adjustment, and stronger stimuli to elevated enzyme activity as well. With increasing doses of O3 this elevation in enzyme activity was found to be gradually diminished, possibly due to a steadily growing demand, leaving the overshoot becoming continually smaller until a balanced state is achieved.
Antiviral vaccines/cancer prophylactics?
Journal: JAMA (1983)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Type A botulism from sauteed onions. Clinical and epidemiologic observations
Authors: K. L. MacDonald
Journal: JAMA (1985)

Twenty-eight persons were hospitalized in Illinois with neurologic signs and symptoms compatible with botulism in October 1983. Twelve patients required ventilatory support, and 20 patients were treated with trivalent ABE antitoxin; one patient died while still in the hospital six months after onset of illness. Type A toxin and/or type A<i>Clostridium botulinum</i>were subsequently identified in specimens from 18 patients. Case-control studies implicated sauteed onions made from fresh raw onions and served on a patty-melt sandwich in a local restaurant as the vehicle of transmission. Although the original sauteed onions were not available for toxin testing, type A toxin was detected in washings from a wrapper in which a patty-melt sandwich was taken home by one of the ill persons. Also, type A<i>C botulinum</i>was cultured from five of 75 raw onions taken from the restaurant. This outbreak implicated an unusual vehicle for botulinal toxin that was initially not suspected and demonstrates the importance of considering all theoretically possible food items as potential vehicles for toxin until epidemiologic and laboratory data have been collected and analyzed. (<i>JAMA</i>1985;253:1275-1278)
Patient Selection for Permanent Cardiac Pacing.
Authors: Lockhart B. McGuire
Journal: Annals of Internal Medicine (1968)

s1 May 1968Patient Selection for Permanent Cardiac Pacing.Lockhart B. McGuire, M.D. (Associate), J. H. Hollingsworth, M.D., Julian R. Beckwith, M.D., F.A.C.P.Lockhart B. McGuire, M.D. (Associate)Search for more papers by this author, J. H. Hollingsworth, M.D.Search for more papers by this author, Julian R. Beckwith, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-68-5-1159_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn 1963 to 1964 selection of patients for permanent cardiac pacing generally required not only the existence of complete atrioventricular (AV) block but also of recurrent syncope or equivalent symptoms due to block after a trial of drug therapy. The reliability of that selection policy has been assessed by reviewing the status of 25 patients in whom pacemakers were not inserted after initial evaluation because symptoms were judged at that time insufficient to justify the procedure. This group has been compared with a simultaneous group of 33 patients in whom pacemakers were inserted and who have been followed for more... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Charlottesville, Virginia PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1968Volume 68, Issue 5Page: 1159-1160KeywordsCardiac pacingDrug therapyPacemakersSyncope Issue Published: 1 May 1968 PDF downloadLoading ...
Vietnam veterans risk for fathering children with birth defects
Authors: T. D. Sterling
Journal: JAMA (1985)

<h3>In Reply.—</h3> In our reports,<sup>1,2</sup>we note that there was great public concern about the risks of US Vietnam veterans in general for fathering babies with birth defects, as well as about the risks of those who may have been exposed to Agent Orange. These two concerns guided our study design. In those reports, we discuss the difficulty of ascertaining Agent Orange exposure. The estimates of exposure that can be constructed today must derive from personnel and combat records created many years ago. These records were not made for the purpose of conducting health studies, and, in particular, they contain no specific information about individual veterans' exposure to herbicides. At this time, one can attempt only to rank the relative likelihood of individual veterans' exposure, based on the time and location of service in Vietnam in relation to recorded patterns of herbicide usage. Sterling and Arundel state that the
Cancer Research, Chicago
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Chest Physicians
Authors: W. D. W. Brooks, F. P. Lee Lander, J. G. Scadding, N. C. Oswald, H. Nicholson, F. H. Scadding, J. R. Bignall, J. C. Batten, K. M. Citron, J. Smart, E. E. Keal, P. A. Zorab, M. E. H. Turner-Warwick, A. F. Foster-Carter
Journal: BMJ (1969)
Medical Economics
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Vaporizer Performance: Closed Circuit Fluothane Anesthesia
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
DNA banding patterns in carcinoma of the bladder
Authors: W. H. Falor
Journal: JAMA (1973)

With the introduction in 1970 of DNA staining techniques productive of specific banding patterns in each chromosome, detailed chromosomal morphology became apparent, and precise karyotyping was a reality. To study the banding patterns of malignant tumors, six moderately well-differentiated transitional cell carcinomas of the bladder subjected to the direct squash procedure were stained by the acid-saline-Giemsa technique. Chromosomes A-2, B-4, and D-13 showed the most consistent patterns. Two marker chromosomes characterized the six tumors: marker l, a long submetacentric, was present in 66% of the karyotypes and marker II, resembling a B-4, was present in 28%. These markers, coupled with the subtetraploid mode of the six tumors, were unique when compared with well-differentiated and poorly differentiated bladder carcinomas. Potentially, DNA banding provides a more accurate method of classification, including assay of invasiveness, of malignant neoplasms of the bladder.
Socioeconomic inequalities in health. No easy solution
Authors: N. E. Adler
Journal: JAMA (1993)

<h3>Objective.</h3> —Socioeconomic status (SES) is strongly associated with risk of disease and mortality. Universal health insurance is being debated as one remedy for such health inequalities. This article considers mechanisms through which SES affects health and argues that a broader and more comprehensive approach is needed. <h3>Data Sources.</h3> —Published articles surveyed using MEDLINE and review articles and bibliographies. <h3>Methods and Results.</h3> —Research is reviewed on the association of SES with health outcomes in different countries, including those with universal health coverage. Socioeconomic status relates to health at all levels of the SES hierarchy, and access to care accounts for little of this association. Other mechanisms are suggested and implications for policy and clinical practice are discussed. <h3>Conclusion.</h3> —Health insurance coverage alone is not likely to reduce significantly SES differences in health. Attention should be paid both in policy decisions and in clinical practice to other SES-related factors that may influence patterns of health and disease. (<i>JAMA</i>. 1993;269:3140-3145)
American Journal of Ophthalmology, Chicago
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Poisoning by Arsenic: Medico-legal Investigation
Journal: BMJ (1841)

POISONING FROM1 ARSENIU.'2.57 unider thle sanction of the latw of at civilized anid professedly Christiin country, aflords an example of callousiiess anid defect of social qtualities in those wlio hiave giveni aiutlhority to such a systcnii, as ImiUst ulti- inaLtely tend to wveaken their powers as legislators for at social people, anid to lesscil that respect fbr the laws generatlly, whiclh is ilecessary to the well-bein^, of any colnmullity or state.
Chemosurgery for basal cell carcinoma
Authors: J. B. Moles
Journal: JAMA (1969)

A series of basal cell carcinomas was treated by chemosurgery, a technique of fixation in situ, followed by excision and microscopic examination of frozen sections of the tumor. This technique was applied to a group of basal cell carcinomas which other specialists preferred not to treat by more conventional methods. Because of the advantages of chemosurgery along with the short- and long-term results, we conclude that the method should be employed more widely.
<i>Errata</i>: Vol. 65, No. 6
Journal: MMWR Morbidity and Mortality Weekly Report (2016)

In the report, "Notes from the Field: Administration Error Involving a Meningococcal Conjugate Vaccine - United States, March 1, 2010-September 22, 2015," on page 162, the end of the first paragraph should contain an additional sentence as follows: "However, because serogroup A meningococcal disease is rare in the United States, patients only receiving the liquid MenCYW-135 component of Menveo might not need revaccination, unless international travel is anticipated (especially travel to Africa) (3,6)."
Incidents of the Influenza Epidemic.—
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Interleukin 2
Authors: G. J G Rees
Journal: BMJ (1990)

argues in his editorial that interleukin 2 has emerged as a treatment capable of inducing complete responses in patients with cancers that were previously thought to be unresponsive to treatment.'He cites as examples malignant melanoma and renal cell cancer.The assertion that malignant melanoma is unresponsive to conventional chemotherapy is unfounded and misleading.Data were presented last year on response to treatment according to the International Union against Cancer criteria and survival of patients with surgically incurable metastatic melanoma who were treated between June 1977 and June 1989 at Westminster Hospital with four consecutive chemotherapy protocols that were developed in this unit (S Retsas, second international conference on melanoma, Venice, 1989).The table summarises the updated information on 350 patients in this study.
Chylothorax, chylopericardium and lymphoedema – the presenting features of signet-ring cell carcinoma
Authors: N. Mogulkoc, B. Onal, N. Okyay, O. Günel, U. Bayindir
Journal: European Respiratory Journal (1999)

This case study describes a successful pregnancy in a 27-yr-old patient with severe emphysema, secondary to alpha1-antitrypsin deficiency, genotype PiZZ. Despite significant respiratory compromise, more severe than previously reported, no complications ensued. Maternal pulmonary function did not deteriorate significantly until the 32nd week of pregnancy, with an elective Caesarean section being performed during the 37th week. This experience suggests that even severe maternal airflow obstruction is, in itself, not an absolute contra-indication to pregnancy. Pre-pregnancy multidisciplinary counselling is likely to be helpful in these patients, including frank discussion on the risks of pregnancy, the prospects of successful completion and the mother9s future prognosis in relation to caring for the child.
Foreword
Authors: A M Denman
Journal: Annals of the Rheumatic Diseases (1993)

Investigators pondering the cause of inflammatory rheumatic diseases have been largely preoccupied with immunology since the discovery of autoantibodies over 30 years ago.The ability to initiate organ specific autoimmune diseases by the experimental presentation of organ specific autoantigens to the immune system gave a further incentive to pursue this theme.An analysis of the major rheumatological journals shows that on average some 10-1 5% of all articles published over the past 20 years have a major immunological component, and this takes no account of immunological investigations into the rheumatic diseases appearing in other scienti& journals.Much of this massive body of data has informed us about immunopathological mechanisms.For example, it is highly probable that cytokines synthesised in the rheumatoid synovial membrane make a major contribution to cartilage degradation.Similarly, it is likely, though less securely established, that HLA associations with rheumatic diseases operate through T cell recognition of genetically determined, topographical variations of oligopeptides presented in the antigen-presenting grooves.However, not unreasonably, rheumatologists and their patients ask relatively simple questions about cause, effect, and interdiction, and it is in this context that the contribution of immunology to rheumatological understanding has also to be assessed.
Immunochemotherapy with Fludarabine (F), Cyclophosphamide (C), and Rituximab (R) (FCR) Versus Fludarabine (F), Cyclophosphamide (C) and MabCampath (Cam) (FCCam) in Previously Untreated Patients (pts) with Advanced B-Chronic Lymphocytic Leukemia (B-CLL) : Experience On Safety and Efficacy within a Randomised Multicenter Phase III Trial of the french Cooperative Group On CLL and WM (FCGCLL/MW) and the “Groupe Ouest-Est d'Etudes Des Leucémies Aigües Et Autres Maladies Du sang” (GOELAMS) : …
Authors: Stephane Lepretre, Therese Aurran, Beatrice Mahe, Bruno Cazin, Olivier Tournihlac, Hervé Maisonneuve, Olivier Casasnovas, Alain Delmer, Veronique Leblond, Bruno Royer, Brigitte Corront, Sylvie Chevret, Roselyne Delepine, Sandrine Vaudaux, Eric Van Den Neste, marie-Christine Béné, Florence Cymbalista, Pierre Feugier
Journal: Blood (2009)
A novel, stiff-shaft, flexible-tip guidewire for cannulation of biliary stricture during endoscopic retrograde cholangiopancreatography: a randomized trial
Authors: Jörg Albert, Katja Lucas, Natalie Filmann, Eva Herrmann, Oliver Schröder, Christoph Sarrazin, Jörg Trojan, Bernd Kronenberger, Jörg Bojunga, Stefan Zeuzem, Mireen Friedrich-Rust
Journal: Endoscopy (2015)

Correction to: A novel, stiff-shaft, flexible-tip guidewire for cannulation of biliary stricture during endoscopic retrograde cholangiopancreatography: a randomized trialEndoscopy 2014; 46(10): 857-861DOI: 10.1055/s-0034-1377628
Heart Disease Case Finding by Means of 70 Millimeter Photofluorographic Films
Authors: DAVID D. RUTSTEIN, CHARLES R. WILLIAMSON, FELIX E. MOORE
Journal: Circulation (1951)

These studies concern the value of the 70 mm. photofluorographic tuberculosis film as a heart disease case finding procedure. The yield of cases discovered and benefited in the group I study would be considered satisfactory in comparison with yields usually obtained in mass surveys for other diseases. This was not so in the group II study, and the reasons for the differences are discussed.