tbuckley/cabot-search huggingface dataset:
Perspective on Therapy
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Highlights
Authors: Richard Smith, David Audio
Journal: JAMA (2014)

In an analysis of publicly available US Food and Drug Administration (FDA) documents from 448 efficacy trials of 188 novel therapeutics approved between 2005 and 2012, Downing and colleagues examined the strength of the clinical evidence supporting the approval decisions.The authors found wide variation in the quality of evidence used as a basis for approvals, particularly in the choice of comparators and end points and in trial duration, size, and completion rate.
Surgical technique for implantation of the Jarvik-7-100 total artificial heart
Authors: W. C. DeVries
Journal: JAMA (1988)

THE FIRST total artificial heart was implanted in a dog by Akutsu and Kolff<sup>1</sup>in 1957; this device sustained life for six hours. Since then, animal survival times with the artificial heart have increased dramatically, and refinements in the mechanics of the device have resulted in the development of an effective, gentle blood pump operated by a hemodynamically responsive drive system.<sup>2,3</sup> Human use of a total artificial heart occurred initially in 1969 and again in 1981.<sup>4,5</sup>Cooley performed these first two implants as an interim measure until orthotopic cardiac transplantation could be accomplished. His efforts were followed by the first implantation of an artificial heart as a permanent replacement for the human heart in 1982.<sup>6,7</sup>By the end of 1986, a total of five permanent implant procedures had been accomplished, and 38 devices had been implanted as a bridge to transplantation.<sup>8,9</sup>As technological advances result
A Text-Book of Histology.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Low-dose radiation: latest data renew questions of 'safe' level
Authors: C. Marwick
Journal: JAMA (1990)

THE US DEPARTMENT of Energy has begun to release data about the health effects of low-dose radiation on workers in the agency's nuclear facilities. The action marks a turning point. For the first time, there will be outside assessments of unexpurgated records from the Department of Energy on the effects of radiation for some 600 000 workers. The agency's action follows the report of an "outside" (of the department) committee that had been given the task (by ADM James D. Watkins, secretary of the Department of Energy) of evaluating the effectiveness and quality of the department's epidemiologic and occupational health activities. The committee, which has completed its task, has the classically bureaucratic title of the Secretarial Panel for the Evaluation of Epidemiologic Research Activities (usually referred to by its acronym, SPEERA), and was chaired by Kristine Gebbie, RN, MSN, the health secretary for Washington State. Among its recommendations, the committee
Vascular Surgery
Authors: John Bergan
Journal: JAMA (1978)

Although modern vascular surgery had its beginnings much earlier, its years of growth and flourish are a phenomenon of the second half of this century. Earlier achievements and observations were summarized in 1946 in the first edition of<i>Peripheral Vascular Diseases</i>by Allen, Barker, and Hines. For many physicians and even the few surgeons who were to create the specialty of peripheral vascular surgery, this book was the Bible. Now, in Rutherford's contribution, we see what must be considered the definitive current statement on surgical treatment of peripheral vascular conditions. Nearly everything in this volume pertains to observations made during the last 25 years. Most is written by physicians who had not yet graduated from medical school during the rapid advancement of vascular surgery during the 1950s. It is doubtful, however, that this book will be considered the Bible of vascular surgery. The field, unlike religion, changes too rapidly. Also,
Torulopsis glabrata pneumonitis in patients with cancer. Report of three cases
Authors: J. Aisner
Journal: JAMA (1974)

HEMATOLOGIC neoplasms and their therapy frequently result in seriously altered host defenses, thus enhancing susceptibility to infection with opportunistic organisms.<i>Torulopsis glabrata</i>is a yeast-like organism commensal in the vagina of healthy women.<sup>1</sup>Human infection is rare, but may occur in patients with altered host defense mechanisms. The organism has been reported to cause esophagitis,<sup>2</sup>endometritis,<sup>1</sup>cystitis,<sup>3</sup>pyelonephritis,<sup>3</sup>wound infection,<sup>3</sup>and fungemia,<sup>1,3,4</sup>nd has been isolated from sputum and lung tissue at autopsy.<sup>2</sup><i>Torulopsis glabrata</i>has been isolated at the Baltimore Cancer Research Center on surveillance cultures,<sup>5</sup>and occasionally from lung tissue at autopsy, but antemortem clinical pneumonitis has not previously been recognized. This organism was implicated as the cause of a fatal pneumonia in a severely myelosuppressed patient.<sup>1</sup>The cultures were obtained five hours postmortem and were not taken directly from the area of involvement; nevertheless, histological examination of
US medical school finances
Authors: P. Jolly
Journal: JAMA (1986)

The 26th annual review of medical school finances, prepared by the Division of Operational Studies of the Association of American Medical Colleges (AAMC), is intended to reflect, through financial analysis of revenues and expenditures, the secular trends in medical education in the United States. The 26-year interval comprises two distinct periods. The first period from 1958-1959 to 1978-1979 can be characterized by huge absolute and relative increases in all aspects of medical education. Some sense of the growth in the enterprise over the 21-year interval from 1958-1959 to 1978-1979 may be gleaned from an examination of a few of its dimensions shown in Table 1. The number of schools increased, the number of candidates for professional and academic doctorates doubled and tripled, respectively, and the population of postdoctoral students mushroomed. The five-year period from 1979-1980 to 1984-1985, on the other hand, exhibits modest growth in the number of schools and
Abstract 4562: Real-time Transthoracic Three-dimensional Echocardiography Provides Valuable Management Information in Double Outlet Right Ventricle: An Echocardiographic-surgical Correlative study
Authors: Akio Inage, Ken Takahashi, Ivan Rebeyka, David Ross, Jeffrey F Smallhorn
Journal: Circulation (2008)

Objective: To assess the incremental value of real-time transthoracic three-dimensional echocardiography (RT3DE), over two-dimensional echocardiography (2DE) in determining the adequacy of the interventricular communication (IC) and surrounding structures in double outlet right ventricle (DORV). Background: The IC size which is crucial to the management of DORV is different from the “hole” closed by the surgeon. If the IC communication is too small post operative left ventricular outflow tract obstruction can occur. Methods: Twenty patients with DORV, mean age of 1.2 years (range 0 day to 8 years) and mean body weight of 7.1 kg (range 3.1 to 21.8 kg), were examined with RT3DE, as well as 2DE. Full volume RT3DE data sets were acquired in all, using either an X3–1 or X7–2 Matrix-Array transducer (Philips Medical System). Data analysis was performed using offline Philips QLabs. We measured end diastolic (ED) and end systolic (ES) area of the IC and the “hole” closed by the surgeons by RT3DE and 2DE, and adjusted them by body surface area (BSA). As well, we measured the tricuspid to aortic and tricuspid to pulmonary valve distance (TV-AV and TV-PV distance) by RT3DE and determined the relationship of the tricuspid valve to the IC. Results: Four patients had an associated muscular VSD. The mean ED and ES IC area/BSA were 7.33 ± 3.94 and 4.25 ± 1.86 cm 2 /m 2 by RT3DE and 3.41 ± 1.9 and 2.00 ± 1.29 cm 2 /m 2 by 2DE respectively. The mean ED and ES “surgical hole” area/BSA were 10.62 ± 3.94 and 6.52 ± 2.65 cm 2 /m 2 by RT3DE and 5.90 ± 2.47 and 4.27 ± 1.36 cm 2 /m 2 by 2DE respectively. ED and ES IC and “surgical hole” areas were significantly different between RT3DE and 2DE (P value ranges: 0.024 to &lt; 0.001). 2DE tended to underestimate IC and the “surgical hole” size. The TV-AV and TV-PV distance relationship by RT3DE could be determined and was consistent with current surgical practice for DORV. The precise relationship of tricuspid valve attachments in the vicinity of the IC were readily determined by RT3DE, but not by 2DE. Conclusion: RT3DE provides useful and additive information, and offers simulated intraoperative visualization of true IC and the “surgical hole” in DORV as well as the surrounding structures.
Malaria
Authors: Quentin M. Geiman
Journal: New England Journal of Medicine (1948)

IN 1943 an article was written to review the significant concepts and facts about malaria among human beings.1 In that account, a brief allusion was made to the comprehensive program placed in operation by the armed forces to control malaria. Nothing could be said at that time about the extensive mobilization of clinicians, chemists, parasitologists and entomologists and the training of skilled personnel to attack unsolved malarial problems, which were of extreme strategic importance to the Allies.Sufficient time has elapsed since the close of World War II to evaluate the foremost advances made in the knowledge of malaria in . . .
THE CARNEGIE INSTITUTION AND MEDICAL RESEARCH.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Gene therapy for brain tumors in trials, correction of inherited disorders a hope
Authors: T. Randall
Journal: JAMA (1993)

CLINICIANS and laboratory scientists alike have coveted the ability to genetically alter brain cells. Were this manipulation possible, brain cancer conceivably could be cured. So could the multitude of other acquired and inherited diseases that involve the central nervous system. From a basic science standpoint, researchers could pry open the mysteries of neural development and other enigmas by studying the function and regulation of cloned genes in animal models. For many years, however, the brain has proven intractable to the embryonic science of gene transfer. Because brain cells do not proliferate, the early protocols that required DNA replication for the delivery of genetic material were ineffective. Moreover, the blood-brain barrier rendered the brain impenetrable to systemic-based therapies. But scientists are learning to overcome these obstacles and in some cases even use them to their advantage. Eight patients have now been treated in the first gene therapy trial for malignant brain
Progress in neurology and psychiatry; an annual review. Vol. XVII.
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abnormal Insulin in Myocardial Infarction
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
High TMB Predicts Immunotherapy Benefit
Journal: Cancer Discovery (2018)

The first data from the phase III CheckMate-227 trial of ipilimumab plus nivolumab for the treatment of non-small cell lung cancer suggests that the two drugs boost progression-free survival in patients with a high tumor mutation burden. After 1 year, progression-free survival was 43% for patients treated with the checkpoint inhibitor combination, compared with 13% for patients treated with chemotherapy.
International Comments
Journal: JAMA (1977)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Acquired immunodeficiency syndrome, opportunistic infections, and malignancies in male homosexuals. A hypothesis of etiologic factors in pathogenesis
Authors: J. Sonnabend
Journal: JAMA (1983)

The acquired immunodeficiency syndrome (AIDS) occurs in a subgroup of male homosexuals having sexual contact with a large number of partners. Uncommonly, AIDS has also been diagnosed in Haitians, hemophiliacs, and intravenous drug users and their infants. Manifestations include autoimmune disturbances, opportunistic infections, Kaposi's sarcoma, chronic lymphadenomegaly, non-Hodgkin's lymphoma, or squamous cell carcinoma. The hypothesis receiving most consideration is that a yet-to-be-identified virus causes AIDS. An alternative view is that repeated sexual involvement with multiple partners, in a subgroup of male homosexuals, exposes the men to the immunosuppressive impact of cytomegalovirus (CMV) and allogeneic semen. Antibody to asialo-Gm<sub>1</sub>and other antigens on sperm react with and impair lymphoid cells. We propose a biphasic process. First, a reversible acquisition phase of impaired T-cell immunoregulation permits reactivation of Epstein-Barr virus (EBV), and autoantibodies are produced by the activated B cells. If sexual activity continues at a high level, accumulating immune defects, including destruction of thymic epithelium, lead to a second, self-sustaining phase wherein cytotoxic lymphocytes fail to eliminate herpesvirus-infected cells. Evidence is mounting that Kaposi's sarcoma is caused by CMV and that EBV is responsible for the B-cell lymphomas in these patients. Multiple factors, rather than a novel virus, probably induce AIDS in male homosexuals. If this hypothesis is correct, then rational bases for prevention and intervention can be designed. (<i>JAMA</i>1983;249:2370-2374)
Don't place alcohol on a pedestal
Authors: M. A. Block
Journal: JAMA (1976)

I DEPLORE the attempt being made by apparently qualified scientists to develop a technique whereby the proved alcoholic can be taught to drink without slipping into further dependence. This effort goes far to undermine the prime objectives of those of us who have worked in this field for many years. It seeks to elevate an addictive drug to a kind of sovereign social status so that certain of its victims may try to circumvent its deleterious effects. It flies in the face of endeavors to bring people to the realization that life can be rewarding without resort to drugs. Instead of combating the drug culture that incubates alcohol abuse and helping us to erect sound defenses against it, these comparative newcomers in the field tend rather to regard alcohol as a social necessity, whose drug effect is acceptable, even though dependence has been already established in its victims. For years,
Society Proceedings
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
EMPLOYMENT FOR CURED TUBERCULOSIS PATIENTS
Journal: JAMA (2011)

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