tbuckley/cabot-search huggingface dataset:
Insects and Disease.
Journal: JAMA (1910)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Synergistic Toxicity of Gram-Negative Bacteria and Colloidal Hemoglobin
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
American Journal of Clinical Pathology, Indianapolis
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Comparison of Chemical-Activated Luciferase Gene Expression Bioassay and Gas Chromatography for PCB Determination in Human Serum and Follicular Fluid
Authors: Peter H. Cenijn, Paul J. C. Schepens, Abraham Brouwer
Journal: Environmental Health Perspectives (2000)

We assessed exposure to dioxin-like compounds using chemical and bioassay analysis in different matrices in a female population. A total of 106 serum and 9 follicular fluid samples were collected from infertile women attending Centers for Reproductive Medicine in Belgium from 1996 to 1998. Major polychlorinated biphenyl (PCB) congeners were quantified by chemical analysis using gas chromatography with electron-capture detection, and the chemical-activated luciferase gene expression (CALUX) bioassay was used to determine the total dioxin-like toxic equivalence (TEQ) of mixtures of polyhalogenated aromatic hydrocarbons present in body fluids, such as serum and follicular fluid. To the best of our knowledge, this is the first investigation to determine TEQ values by the CALUX bioassay in follicular fluid. The TEQ levels in both matrices are well correlated (r = 0.83, p = 0.02). As the chemical and bioassay analysis executed in this study do not cover the same span of polyhalogenated aromatic hydrocarbons, we did not expect totally correlated results. Moreover, the sample workup and quantification of the analytes differed completely. Nonetheless, the TEQ values in human extracts correlated well with the sum of four major PCB congeners chemically determined in both serum and follicular fluid. These results indicate that the CALUX bioassay may serve as a simple, relatively inexpensive prescreening tool for exposure assessment in epidemiologic surveys.
Schweizerische Medizinische Wochenschrift, Basel
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Healthful Womanhood and Childhood.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
LAW AND MEDICINE
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Central nervous system dysfunction following open-heart surgery
Authors: H. M. Tufo
Journal: JAMA (1970)

A prospective study of the conditions of 100 open-heart surgery patients elicited more precise information about incidence, characteristics, and causes of central nervous system dysfunctions after surgery. Neurological, psychometric, and behavioral observations were made preoperatively and postoperatively. Half the sample developed neurological damage following recovery from anesthesia. Forty-three percent of survivors developed behavioral abnormalities preceded by focal neurological damage; intellectual functions were depressed in all such patients. In most patients neurological signs and mental symptoms disappeared and mental status normalized by discharge. However, 15% of survivors had signs of cerebral damage at discharge. Cerebral damage was significantly related to increasing age and depression of arterial pressure. In patients with cerebral dysfunction, arterial pressure fell to levels which did not support adequate cerebral perfusion. Older patients were especially vulnerable to such effects. Neuropathological findings suggested cerebral ischemia.
Survival following massive barbiturate ingestion
Authors: M. Terplan
Journal: JAMA (1966)

BARBITURATE intoxication is becoming increasingly common. The prevalence of unsuccessful suicide attempts in this country has been reported to be almost 4% of the general urban population,<sup>1</sup>and, at least in San Francisco, drug ingestion is the most commonly used method for suicide.<sup>2</sup>This report concerns a patient who ingested 20 gm of amobarbital (Amytal) with a measured level of barbiturate in the blood of 16 mg/100 ml. To our knowledge, survival after a dose of this magnitude has not been recorded. <h3>Report of a Case</h3> A 52-year-old single, white man, a known hypertensive diabetic, was admitted comatose and apneic to a community hospital approximately two hours after having ingested one hundred 0.2-gm amobarbital capsules. His initial management included placement of an indwelling bladder catheter, an endotracheal tube with positive pressure breathing, and fluids including mannitol and metaraminol (Aramine) bitartrate via venous cutdowns. An attempt to pass a
NUTRITIONAL AMBLYOPIA
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Physiology
Authors: Hebbel E. Hoff
Journal: New England Journal of Medicine (1946)

A CONSIDERATION of current publications that describe physiologic investigations carried out under the impetus of war suggests that, in this field as in others, greater progress was made in the application of known basic principles than in the discovery of new material. This is not, however, entirely the case. Thus, the pharmacologic screening of thousands of previously untested toxic compounds for potential value as chemical-warfare agents has uncovered many that hold promise as therapeutic agents or as tools in future physiologic investigations.1 The great practical advance in the production of radioactive material will certainly be of inestimable value in the . . .
A phase 1/2 open label extension study of givosiran, an investigational RNAi therapeutic, in patients with acute intermittent porphyria
Authors: Penelope Stein, David Rees, Karl Anderson, Herbert Bonkovsky, Eliane Sardh, Pauline Harper, Manisha Balwani, Charles Parket, John Phillips, Daphne Vassiliou, Craig Penz, Amy Chan, Gary Liu, Amy Simon, D Montgomery Bissell
Journal: Journal of Hepatology (2020)
Lost Papers.
Authors: J. D. Plunket
Journal: JAMA (1891)

<i>Editor A. M. A. Journal</i>, 68 Wabash Ave., Chicago, Ill. <h3>Dear Sir:</h3> —On yesterday the clerk of the Maxwell House here, handed me a package of papers, which proved to be the notes and original papers read in the Section of Practice of Medicine, at the meeting of the Association held at this place in May, 1890. They evidently were lost, and only now have come to light. If you desire the package, I will forward it to you, as many of the essays bear the marks of careful preparation, and no doubt the authors would be glad to either get their copy again or have it published by you. Very truly yours, Nashville, Tenn., October 17, 1891. The misplacement and apparent loss of the papers of the Section on Medicine last year was a source of much trouble to the Editor ofThe Journal, and every possible means was
Prognostic Factors and Treatment Decisions in Axillary-Node-Negative Breast Cancer
Authors: Jane F. Desforges, William L. McGuire, Gary M. Clark
Journal: New England Journal of Medicine (1992)

Approximately 186,000 new cases of breast cancer will occur in the United States in 1992, and about two thirds of these cases will not involve axillary nodes. This means that each month decisions about adjuvant therapy will be made for more than 10,000 patients with node-negative breast cancer.Why not simply treat all patients with node-negative breast cancer with additional systemic therapy?1 , 2 One should not, for the following reasons. First, approximately 70 percent of such patients are cured without any adjuvant therapy. Thus, a large number of women without disease would be subjected to the toxic effects of this therapy . . .
Comparative Studies on the Cytotoxicity of Amphibole and Serpentine Asbestos
Authors: John E. Craighead, Brooke T. Mossman, Bruce J. Bradley
Journal: Environmental Health Perspectives (1980)

The chemical and physical properties of serpentine and amphibole asbestos are considered in the context of their interaction with tissue of the tracheobronchial tree and lungs. In vitro studies in cultures of several types are evaluated and work with the erythrocyte hemolysis system is reviewed. Although fibers of the two major mineral types differ substantially, it is likely they are modified by secretions and membranes of cells after inhalation to the respiratory tract. Investigations using virgin asbestos might not provide an accurate picture of events in vitro.
Abstract 16194: Prognostic Value of Cardiac Magnetic Resonance T2 Quantification in Heart Transplant Patients: A 5-year Outcome Study
Authors: Varun Chowdhary, Spencer B Barfuss, Yi Gao, Julie A Blaisdell, Mary A Ackerman, Ann Ragin, Michael Markl, James Carr
Journal: Circulation (2015)

Background: Endomyocardial biopsy (EMB) is the current gold standard to monitor patients for heart transplant rejection. Quantification of myocardial T2 relaxation time using cardiac magnetic resonance (CMR) has been shown to have high sensitivity and specificity to detect rejection episodes. In this study, we evaluated the prognostic value of myocardial T2 to predict adverse cardiovascular outcomes during 5-year follow-up after initial CMR. Methods: 49 cardiac transplant patients (mean age, 48 ± 14 years; 65% male) were recruited from a single institution. CMR at 1.5T was performed in all patients, with subsequent quantifications of regional and global myocardial T2. Clinical data was gathered post-CMR over a 5-year period. EMBs were graded according to the International Society of Heart &amp; Lung Transplantation criteria. Rejection episodes were defined by EMB ≥ 2R, new onset heart failure (HF), LV ejection fraction &lt; 40%, or death. Adverse cardiovascular events gathered included coronary artery disease, cardiomyopathies, arrhythmias, and different types of HFs. Multivariable logistic regression and Kaplan-Meier analysis was performed to measure the prognostic value of myocardial T2. Results: Myocardial T2 was found to increase with worsening EMB grade from 53.0 ms (0R, no rejection) to 59.9 ms (3R, severe rejection). ROC analysis using two groups (EMBs ≤ 1R and ≥ 2R) showed T2 = 55.0 ms to have the highest specificity and sensitivity. In multivariable analysis that considered T2 measures, age, length of surgery, donor ischemic time, and BMI, both peak T2 (p = 0.038) and septal T2 (p = 0.035) were significant predictors of EMB grade ≥ 2R. Kaplan-Meier analysis showed a significant higher probability of developing EMB ≥ 2R, new onset HF, or death with a global T2 ≥ 55 (p = 0.02). Adverse cardiovascular outcomes of systolic HF, acute systolic HF, and chronic diastolic HF had a higher probability of developing in patients with global T2 ≥ 55 (p = 0.01, p = 0.01, and p &lt; 0.01, respectively). Conclusions: CMR T2 quantification demonstrated prognostic value for all-cause rejection and various types of HFs in cardiac transplant patients. These findings suggest that CMR may be a suitable modality to non-invasively monitor cardiac transplant patients for rejection.
PDTM-20. NONINVASIVE ASSESSMENT OF TREATMENT RESPONSE FOR DIFFUSE INTRINSIC PONTINE GLIOMA USING HYPERPOLARIZED 13C METABOLIC IMAGING
Authors: Ilwoo Park, Adam Autry, Xiaodong Yang, Yuying Zhai, Renuka Sriram, Dave Korenchan, John Kurhanewicz, Adam Cunha, I-Chow Hsu, Sarah Nelson, Sabine Mueller
Journal: Neuro-Oncology (2017)

It remains often challenging on conventional MR imaging to distinguish between true versus pseudo-progression in children with diffuse intrinsic pontine glioma (DIPG). Hyperpolarized 13C MR metabolic imaging is a promising new technology that provides a non-invasive imaging approach to monitor changes in functional properties of tumors. We have shown previously that 13C-pyruvate can be used to monitor the rate and magnitude of conversion to 13C-lactate, which is elevated in tumors due to increased activity of the enzyme lactate dehydrogenase (LDH). We hypothesize that levels of hyperpolarized lactate, detected by monitoring hyperpolarized pyruvate metabolism using 13C MR metabolic imaging, will be modulated in response to therapy and might be a suitable noninvasive biomarker of therapy response. In vitro imaging studies were performed by treating primary DIPG cells (SF8628) with panobinostat and assessing lactate to pyruvate ratios using 13C MR metabolic imaging. Activity of LDH was assessed using spectrophotometric assays. For in vivo studies, SF8628 cells were injected directly into the pons of rats and hyperpolarized 13C imaging was used to assess lactate/pyruvate ratios after therapy with 8 Gy radiation (n=3) compared to control animals (n=3). Pyruvate to lactate conversion was significantly reduced in the panobinostat-treated DIPG cells compared to control (p=0.03). As expected, the reduced lactate signal was associated with decreased levels of LDHA activity compared to control (p=0.03). Rats treated with radiation showed a decrease in lactate/pyruvate at day 2 and 4 compared to baseline, whereas control rats showed a continuous increase in lactate/pyruvate at day 2 and 4 compared to baseline. The results from this study suggest that hyperpolarized 13C metabolic imaging may be a suitable imaging marker to monitor therapy response in DIPG. A phase 1 study trial testing this imaging modality is ongoing.
Incorrect Expansions of NAD and NADH
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
S. 1804
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal