tbuckley/cabot-search huggingface dataset:
What your patients may be reading
Authors: R. Gann
Journal: BMJ (1988)

better word" offers an entertaining journey along the narrow path between erudition and pedantry: a volume intended for the guidance of trainees is neither a handbook nor a manual but an enchiridion; to the classical scholar micturition denotes the desire rather than the process, for which miction is the correct usage.Administrative activities are discussed in chapters on clinical audit, managing a clinical budget, and the care of problem colleagues.Communication is a theme present in several essays- running a pressure group, representing one's colleagues on BMA committees (which some might think is much the same), or starting a patient participation group.Electronic communication and data manipulation are discussed under several headings-electronic mail, making a video tape, searching the literature, and using a word processor.Three experienced authors expound their craft in a whimsical piece on breaking into the correspondence columns of a newspaper, a prescription for the compassionate obituary, and a compendium of hints on writing for money.This is an admirable book-not a mere do it yourself catalogue but rather a stimulating compendium of opportunities for pro- fessional and personal development.Samuel Smiles would have approved.
Prevalence of Human Immunodeficiency Virus Antibody in U.S. Active-Duty Military Personnel, April 1988
Journal: JAMA (1988)

In January 1986, the US Department of Defense began screening all active-duty military personnel for antibody to the human immunodeficiency virus type 1 (HIV-1). A total of 1,752,191 persons who remained on active duty as of April 24, 1988, were screened. HIV-1 antibody was confirmed by Western blot in 2,232 (1.3/1000) of these persons. Information from the armed forces' Reportable Disease Data Base was used to determine the demographic distribution of HIV-1-antibody seroprevalence rates. Antibody prevalence by age ranged from 0.1/1000 for those aged 17-19 years to 2.1/1000 for those aged 25-29 years. Blacks were 3.6 times and Hispanics 2.5 times more likely than non-Hispanic whites to have HIV-1 antibody. Although blacks and Hispanics constituted 50.7% of those who were HIV-1 antibody positive, they represented only 23.4% of all active-duty personnel. Seroprevalence was highest in men, unmarried persons, and enlisted personnel. The Centers For Disease Control will continue cooperating with the Department of Defense in monitoring levels and trends of HIV infection active-duty military personnel and military recruit applicants. Surveys in other accessible populations at both low and increased risk of HIV infection are also under way.
The evaluation of hospital death rates
Authors: L. E. Moses
Journal: JAMA (1986)

The article by Luft and Hunt<sup>1</sup>in this issue ofThe Journalhas acquired an urgent relevancy since it was accepted for publication. In that time interval, the Department of Health and Human Services has begun to release individually identified hospital death rates. Luft and Hunt examined the 1982 experience of patients undergoing cardiac catheterization in the 151 member hospitals of the Commission on Professional and Hospital Activities known to have had cardiac catheterization laboratories in that year. Confidentiality mechanisms ensured that the authors were blind to the identity of the hospitals from which the data came. The age of the patient and the patient's disease are both powerful influences on the probability of death, so the investigators sorted the patients into 12 categories, defined as the possible combinations of three age groups and four diagnostic groups. For each of these 12 categories, the whole-study death rate (across the
THE IMPORTANCE OF BEDSIDE TEACHING
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Thyroid Cancer
Authors: Tobias Carling, Robert Udelsman
Journal: Annual Review of Medicine (2013)

Thyroid cancer is rapidly increasing in incidence, but the mortality rate remains flat. Debate has arisen over the need to detect or treat most thyroid cancers early, given their favorable natural history. The appropriate extent of surgery for thyroid cancer is also controversial: some researchers advocate partial and others total thyroidectomy; some advocate prophylactic central cervical lymph node dissection, whereas others only rarely recommend lymphadenectomy. Although radioactive iodine is effective, its appropriate use and dosage remain controversial. In addition, molecular analysis of thyroid cancer is frequently used for diagnostic purposes involving preoperative fine-needle biopsy specimens as well as to define targetable pathways altered in the disease to guide clinical trials of drug therapy for advanced thyroid cancers.
THE DANGERS OF GELATIN INJECTIONS.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Amniotic Fluid Aspiration
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prophylactic antibiotics in surgery. Practices within surgical services of the Veterans Administration
Authors: A. M. Munster
Journal: JAMA (1979)

A survey of prophylactic antibiotic-prescribing habits among chiefs of surgical services of the Veterans Administration yielded a 99% response. These responses have been compared with guidelines set by an expert committee on antimicrobial use for the VA central office. Assuming that 100% concordance with the standards of the committee is a desired state, the average hospital is approximately one third away from this goal (average score, 62.4%). The majority of errors were those of overuse rather than underuse. The size of the service and the existence of a university affiliation had no influence on the results. Feedback to the chiefs of service regarding the use of antibiotics was informal and tended to be carried out on rounds rather than as a result of formal audits. Most senior surgeons indicated that they would be willing to be influenced by audit guidelines. (<i>JAMA</i>241:717-718, 1979)
Systems and technology for medicine
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abdominal Surgery
Authors: Claude E. Welch
Journal: New England Journal of Medicine (1969)

IN common with previous reports, the last of which appeared two years ago, this paper will summarize recent important contributions to the knowledge of surgical diseases of the abdominal viscera. The flood of articles in this field has continued in an undiminished fashion, so that in many instances, contributions typical of a trend may be included, whereas others, for lack of space, must be omitted. Abstracts in general are brief, and designed to call attention to specific articles for details.Lower Esophagus and CardiaSince some diseases of the lower esophagus require surgical procedures that involve the stomach and intestine . . .
Neuronal Map
Authors: Tracy Hampton
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE CAUSES AND TREATMENT OF PREMATURE BALDNESS.
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 3103: Intraparenchymal delivery of chemokines and immunomodulators to eliminate pediatric brain tumor cells
Authors: Eric S. Nealy, Cole A. DeForest, James Olson
Journal: Cancer Research (2019)

Abstract Pediatric brain tumors are among the leading causes of cancer-related death in children. These malignancies tend to occur in locations of the brain where surgery and radiation can permanently impair a patient’s quality of life. Migratory cells from high grade brain tumors can invade nearby, inaccessible areas of the brain where they may grow unchecked and ultimately lead to patient death. This project seeks to tailor the microenvironment around the tumor cavity to promote the recruitment and elimination of remnant brain tumor cells by microglia and macrophages found in the brain. Our data suggests gradients of classical immune cell chemokines, like CCL2, are also potent chemotactic signals for a variety of patient-derived brain tumor types. Monoclonal antibody blockade of CD47, a cell-surface “don’t eat me” ligand often over-expressed on tumor cells, is effective at promoting the elimination of tumor cells in close-proximity to murine macrophages in vitro. We engineered user-programable hydrogel depots capable of month-long molecule release and implanted them into tumor-bearing mouse brains. Hydrogels incorporated with CCL2 and CD47mAb demonstrated statistically significant co-recruitment of tumor and immune cells and evidence of macrophage-mediated tumor cell death compared to PBS-incorporated gels. These results suggest proper stimulation of immune cells within the brain could be an effective means to eliminate pediatric brain tumor cells without causing structural damage to vital nervous tissues. Our data may be the first steps towards clinical trials for children with incompletely resected brain tumors. Citation Format: Eric S. Nealy, Cole A. DeForest, James Olson. Intraparenchymal delivery of chemokines and immunomodulators to eliminate pediatric brain tumor cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3103.
The Procedure
Authors: Jacques P. Schaerer
Journal: JAMA (1964)

<h3>To the Editor:—</h3> I have used lumbar discography since 1951 and cervical discography since 1960. Of 493 cervical disks which I examined, 127 were either asymptomatic or completely negative. In six patients all of the disks examined were negative. All patients had severe neck complaints. These data certainly do not support Dr. Holt's findings. A survey of medicolegal discography cases which had been settled showed 60% of the patients reporting that they were unchanged, 15% worse, and 25% improved; none had become symptom-free, which demonstrates that Holt's concern with "over-diagnosis" is unfounded. Having injected 50 prisoners, men anxious to participate in the experiment in order to obtain a reduction of 60 days in their sentences and therefore concealing previous neck difficulties, Holt reached his conclusion on x-ray evidence only, completely disregarding pain response, which, in the opinion of all neurosurgeons using discography, is absolutely essential. Holt admittedly undertook his "research
Boxing-Reply
Authors: George D. Lundberg
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Down to earth at Newcastle.
Journal: BMJ (1980)

hepatitis in whom until recently no cause could be identified.There is no evidence implicating the hepatitis A virus, but recent studies have pointed to the non-A, non-B virus.23 24 Hepatitis due to this virus occurs sporadically and nowadays accounts for most cases of post-transfusion hepatitis.Typically the disease is mild or asymptomatic and as most patients do not become jaundiced the condition must often pass un- detected.Long-term follow-up shows, however, that between 25% and 50%0 of patients still have abnormal results in liver function tests after one year, and liver biopsies in many of these patients show chronic active hepatitis, some with cirrhosis.2425 Tests for autoantibodies are negative.The biochemical abnormalities tend to resolve with time without treatment, but whether or not permanent or progressive liver damage occurs is still uncertain: follow-up studies with liver biopsies are awaited.No trials of treatment have yet been completed, so the place of corticosteroids in management is also unknown.Sensitive tests for non-A, non-B hepatitis virus and antibodies are being developed.These should both help prevent post-transfusion hepatitis and define the extent to which this virus is responsible for chronic active hepatitis and cirrhosis.
Abstract 1935: A Magnetic Resonance Imaging Contrast Agent Targeted Towards Activated Platelets Allows In Vivo Detection of Thrombosis and Monitoring of Thrombolysis
Authors: Constantin von zur Muehlen, Dominik Elverfeldt, Julia Moeller, Robin Choudhury, Christoph Hagemeyer, Meike Schwarz, Christoph Bode, Karlheinz Peter
Journal: Circulation (2008)

Platelets are the key to thrombus formation in atherothrombosis and play a major role in plaque rupture. Non-invasive imaging of activated platelets would be of great clinical interest. Here, we evaluate the ability of a magnetic resonance imaging (MRI) contrast agent consisting of microparticles of iron oxide (MPIO) and a single-chain antibody targeting ligand-induced binding sites (LIBS) on activated GPIIb/IIIa to image carotid artery thrombosis and. Anti-LIBS or control antibody were conjugated to 1μm-sized MPIOs (LIBS-MPIO/control-MPIO). Non-occlusive wall-adherent thrombi were induced in BL/6 mice using 6% ferric chloride. MRI (at 9.4 Tesla) of the carotid artery was performed once before (figure , A) and repeatedly in 12min long sequences after LIBS-MPIO/control-MPIO injection. After 36min, a significant signal void, which is the typical effect of iron oxide-based contrast agents, was observed with LIBS-MPIO (figure , B), but not control-MPIO (P&lt;0.01) and corresponded to LIBS-MPIO binding as confirmed by histology. After thrombolysis, in LIBS-MPIO injected mice the signal void subsided, indicating successful thrombolysis (figure , C). On histology, MPIO-content of thrombus, as well as thrombus size, correlated significantly with LIBS-MPIO-induced signal void (both P&lt;0.01). LIBS-MPIO allows in vivo MRI of activated platelets with excellent contrast properties and monitoring of thrombolytic therapy. This approach represents a novel non-invasive technique allowing rapid detection and quantification of platelet-containing thrombi, such as found on the surface of ruptured atherosclerotic plaques.
Isolation of highly purified, functional carboxy-terminally truncated hepatitis B virus middle surface protein activators from eucaryotic expression systems
Authors: E Hildt
Journal: Hepatology (1996)

Carboxy-terminally truncated hepatitis B virus (HBV) middle surface proteins (MHBst) show a transcriptional activator function. Two different subtypes of MHBst activators can be distinguished: an ER-localized type, represented here by MHBst76 (truncated at amino acid 76), and a cytosol-localized type, represented here by MHBst63. To characterize the MHBst activator on the protein level and to analyze posttranslational modifications, we established recombinant baculoviruses encoding for fusion proteins of MHBst76 or MHBst63 and of an amino terminal hexa-his tag. Both proteins could be obtained in high purity by affinity chromatography using Ni-nitrilo-tri-acetate agarose. In addition, 6H-MHBst76 was also isolated from transiently transfected HepG2 cells. Both the Spodoptera frugiperda (Sf9) cell-derived and the HepG2 cell-derived MHBst proteins were found to be unglycosylated. A detailed analysis of Sf9 cell-derived 6H-MHFBst76 by electrospray- ionization mass spectrometry showed that a fraction of this protein is N-terminally acetylated and phosphorylated or sulfated. Electric-field- mediated transfer of the highly purified proteins into reporter cells demonstrated that the isolated proteins are functional transcriptional activators. These experiments further showed that Sf9 cell-derived and HepG2 cell-derived 6H-MHBst do not differ in their functionality. This system allowed production and purification of functional 6H-MHBst in amounts sufficient enough to allow a further detailed analysis of MHBst activators on the protein level.
“Neuropsychiatric adverse drug reactions in children initiated on montelukast in real-life practice.” Brigitte Benard, Valérie Bastien, Benjamin Vinet, Roger Yang, Maja Krajinovic and Francine M. Ducharme.<i>Eur Respir J</i>2017; 50: 1700148.
Journal: European Respiratory Journal (2017)

well tolerated, postmarketing studies have reported serious neuropsychiatric adverse drug reactions (ADRs) leading to a United States Food and Drug Administration warning.