tbuckley/cabot-search huggingface dataset:
Dyslexia. Council on Scientific Affairs
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Queries and Minor Notes.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 2412: Development of a gene signature to predict positive or negative sentinel nodes as a prognostic marker in melanoma
Authors: Audrey J. Majeske, Timothy J. Geddes, Richard Keidan, George D. Wilson
Journal: Cancer Research (2019)

Abstract In recent years, sentinel lymph node (SLN) biopsy has been adopted as a less invasive technique to assess the prognostic outcome of melanoma, whereby draining the key lymph nodes for presence of a tumor decreases unnecessary lymph node dissections and reduces the risk of developing lymphedema. However, this technique only has therapeutic value in patients with SLN-positive tumor nodes, which only represents about half of the population diagnosed with melanoma. In a pilot study, we assessed the predictive efficacy of using a commercialized multi-biomarker next-generation sequencing (NGS) assay (Illumina® Comprehensive Cancer Panel) containing selected genes which have been shown to have a prognostic impact in melanoma progression, to determine whether these can identify primary tumors which do not require SLN biopsy. We used laser capture microdissection to capture pathologist-identified areas of tumor from four groups of samples 1) skin lesions from SLN-positive patients, 2) skin lesions from SLN-negative patients, 3) node samples from SLN-positive patients and node samples from SLN-negative patients; some cases of skin lesions and nodes were matched for the same patient. Sequencing identified 14 genes containing variants in &amp;gt;70% of the positive node samples, which were absent in samples with negative nodes. This included EGFR, PDGFR, ATM, PIK3CA, TP53 and ERBB4. Of note, variants in ERBB4 is of interest as it has been shown in the past to be a potential molecular target in the treatment of melanoma. We are currently validating these preliminary findings in a larger cohort of patients (n=31) and will report on the NGS findings of this study and the efficacy of using genetic biomarkers in skin biopsy samples as a potential prognostic marker for early stage melanoma patients who may not require SLN biopsy. Citation Format: Audrey J. Majeske, Timothy J. Geddes, Richard Keidan, George D. Wilson. Development of a gene signature to predict positive or negative sentinel nodes as a prognostic marker in melanoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2412.
Providing Support and Assistance for Low-Income or Homeless Women
Authors: Lynanne Plummer
Journal: JAMA (1996)

<h3>To the Editor.</h3> —In their well-conducted epidemiologic study of low-income or homeless mothers who are heads of households, Dr Bassuk and colleagues<sup>1</sup>recommend that health agencies ensure that these women "are linked to and follow through with relevant community services" to "improve [their] social economic situation." Our experience indicates that ensuring follow-through is labor-intensive and only modestly successful. Between September 1993 and March 1995 in Colorado Springs, Colo (1990 census population: 397 014), we enrolled and prospectively followed young women at high risk for social and economic crises. Participants were recruited from our sexually transmitted disease clinic and consisted of 17 prostitutes (mean age, 19.4±2.9 years) and 50 comparison women at risk to enter prostitution (mean age, 19.6±2.5 years). Prostitute women had exchanged sex for money, drugs, or goods; comparison women denied ever engaging in prostitution, but admitted to a history of at least 2 of the following: 3
DINITROPHENOL AND ACCELERATED TISSUE METABOLISM
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hepatocellular carcinoma and hepatitis C in the United States
Authors: Hashem B. El-Serag
Journal: Hepatology (2002)

Chronic infection with hepatitis C virus (HCV) is a major risk factor for development of hepatocellular carcinoma (HCC). In general, HCC develops only after 2 or more decades of HCV infection and the increased risk is restricted largely to patients with cirrhosis or advanced fibrosis. Factors that predispose to HCC among HCV-infected persons include male sex, older age, hepatitis B virus (HBV) coinfection, heavy alcohol intake, and possibly diabetes and a transfusion-related source of HCV infection. Viral factors play a minor role. The likelihood of development of HCC among HCV-infected persons is difficult to determine because of the paucity of adequate long-term cohort studies; the best estimate is 1% to 3% after 30 years. Once cirrhosis is established, however, HCC develops at an annual rate of 1% to 4%. Successful antiviral therapy of patients with HCV-related cirrhosis may reduce the future risk for HCC. The incidence of and mortality caused by all HCC has doubled in the United States over the past 25 years, an increase that has affected all ethnic groups, both sexes, and younger age groups. Given the current prevalence of HCV infection among persons 30 to 50 years of age, the incidence and mortality rates of HCC are likely to double in the United States over the next 10 to 20 years. Future research should focus on improving understanding of the incidence and risk factors for HCC, causes of HCV-related carcinogenesis, means of early detection, and better treatment for HCC. (Hepatology 2002;36:S74-S83).
Racial differences in the use of revascularization procedures after coronary angiography
Authors: J. Z. Ayanian
Journal: JAMA (1993)

<h3>Objective.</h3> —To assess whether rates of coronary revascularization procedures differ between blacks and whites after coronary angiography is performed and to assess the relationship of these rates to hospital characteristics. <h3>Design.</h3> —A retrospective cohort study using 1987 and 1988 data on hospital claims and characteristics from the Health Care Financing Administration. <h3>Setting.</h3> —One thousand four hundred twenty-nine acute care hospitals that provide coronary angiography in the United States. <h3>Patients.</h3> —A national sample of 27485 Medicare Part A enrollees, aged 65 to 74 years, who underwent inpatient angiography for coronary heart disease in 1987. <h3>Main Outcome Measure.</h3> —The adjusted odds of revascularization with either coronary angioplasty or bypass graft surgery within 90 days of angiography for whites relative to blacks, controlling for age, sex, region, Medicaid eligibility, principal diagnosis, comorbid diagnoses, and hospital characteristics of ownership, teaching status, urban/suburban or rural location, and availability of revascularization procedures. <h3>Results.</h3> —White men and women were significantly more likely than black men and women, respectively, to receive a revascularization procedure after coronary angiography (57% and 50% vs 40% and 34%, both<i>P</i>&lt;.001). The adjusted odds of receiving a revascularization procedure after coronary angiography were 78% higher for whites than blacks (95% confidence interval for odds ratio, 1.56 to 2.03). Statistically significant racial differences in the adjusted odds of receiving a revascularization procedure were present in all types of hospitals except rural hospitals, and these differences did not vary significantly by any of the four hospital characteristics (all<i>P</i>&gt;.20 for interaction terms). <h3>Conclusions.</h3> —Among Medicare enrollees, whites are more likely than blacks to receive revascularization procedures after coronary angiography. Racial differences of similar magnitude occur in all types of hospitals. These differences may reflect overuse in whites or underuse in blacks, but they are unlikely to reflect access to cardiologists or hospitals that perform revascularization procedures. Potential explanations include unmeasured clinical or socioeconomic factors, differing patient preferences, and racial bias at the hospitals performing angiography. (<i>JAMA</i>. 1993;269:2642-2646)
ELMIRA REFORMATORY.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The scintigraphic definition of pulmonary embolism
Authors: B. J. McNeil
Journal: JAMA (1974)

Pulmonary scintigrams were analyzed in conjunction with matched pulmonary angiograms for perfusion patterns, relation of perfusion to ventilation, and changes, with time, in the perfusion pattern. Eighty percent of the patients with lobar defects seen on scan and 30% with segmental or subsegmental defects had angiographic evidence of pulmonary embolism. Patients with lobar defects and pulmonary embolism had a lower incidence of findings on chest roentgenograms than did the other groups. Of the 20 patients with mismatched abnormalities of perfusion and ventilation, 19 had pulmonary emboli; none of the five patients with matched perfusion and ventilation had emboli. A rapidly changing perfusion pattern was found in ten patients with acute pulmonary embolism while a fixed pattern was found in five patients who did not have emboli. The data indicate that a large perfusion defect and a ventilation-perfusion mismatch correlate strongly with pulmonary embolism.
HEALTH IN MICHIGAN.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Liver-Brain Relationships in Hepatic Coma
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Community Needs Assessment of Lower Manhattan Residents Following the World Trade Center Attacks—Manhattan, New York City, 2001
Journal: JAMA (2002)

On September 11, 2001, terrorists attacked and destroyed the World Trade Center (WTC) in New York City (NYC). An estimated 2,819 persons were reported killed in the attacks; many others were injured (Office of the Chief Medical Examiner, New York City Department of Health and Mental Hygiene [NYCDOHMH], unpublished data, 2002). An estimated 25,000 persons living nearby in lower Manhattan were affected both physically and emotionally. Many persons witnessed the attacks; lost family and friends; were exposed to smoke, dust, and debris; and evacuated their homes. To identify the health-related needs and concerns of persons residing near the attack site, NYCDOHMH, in collaboration with CDC, surveyed persons residing in areas immediately surrounding the WTC site. The primary purpose of the survey was to gather information to set priorities and direct public health interventions. This report summarizes findings from the assessment, which indicate that a large proportion of respondents had physical and psychological symptoms potentially associated with the exposure and needed information to address their health and safety concerns. On the basis of the results of the survey, NYCDOHMH responded to resident concerns, helped reduce exposure to dust and debris, and provided information about mental health resources.
Reply:
Authors: Benjamin L. Shneider, Eve A. Roberts, Regino P. González-Peralta
Journal: Hepatology (2007)

We appreciate the insightful comments from Dr. Bortolloti and her colleagues based on their long experience with a unique and interesting cohort of children and young adults with chronic HBV infection.1 Their observations, published at the time of the Single Topic Conference and well after planning for the conference was concluded,2 emphasize the complexity of pediatric chronic hepatitis B. The experience described from the University of Padova is exactly the type of arduous follow-up required to make appropriate informed decisions about the management of children with chronic HBV infection. The majority of children in this Italian cohort apparently developed infection as the result of intrafamilial spread of HBV; their disease was associated with biochemical and histological abnormalities and resolution of viral replication in most infected persons. This is quite distinct from the course of perinatally acquired HBV, more common in other parts of the world, where viral infection results in little, if any, liver disease during childhood, despite the presence of high levels of HBV in blood. We applaud the work done by Dr. Bortolloti and her colleagues and look forward to similar long-term studies of other cohorts of children with chronic HBV infection from around the world. Clearly, such studies will be needed to make sound recommendations regarding treatment decisions and liver cancer surveillance in children with chronic HBV infection. Funding of international networks for these much needed long-term follow-up and prospective cross-sectional surveys of chronic HBV infection in children would be extremely useful. Benjamin L. Shneider M.D.*, Eve A. Roberts M.D. , Regino P. González-Peralta M.D. , * Visiting Professor of Pediatrics, Children's Hospital of Pittsburgh, Pittsburgh, PA, Professor of Pediatrics University of Toronto, Toronto, Canada, Associate Professor of Pediatrics University of Florida, Gainesville, FL.
Infectious Disease Surveillance During Emergency Relief to Bhutanese Refugees in Nepal
Authors: Anthony A. Martin
Journal: JAMA (1994)

<h3>Objective.</h3> —To implement simplified infectious disease surveillance and epidemic disease control during the relocation of Bhutanese refugees to Nepal. <h3>Design.</h3> —Longitudinal observation study of mortality and morbidity. <h3>Setting.</h3> —Refugee health units in six refugee camps housing 73 500 Bhutanese refugees in the eastern tropical lowland between Nepal and India. <h3>Interventions.</h3> —Infectious disease surveillance and community-based programs to promote vitamin A supplementation, measles vaccination, oral rehydration therapy, and early use of antibiotics to treat acute respiratory infection. <h3>Main Outcome Measures.</h3> —Crude mortality rate, mortality rate for children younger than 5 years, and cause-specific mortality. <h3>Results.</h3> —Crude mortality rates up to 1.15 deaths per 10000 persons per day were reported during the first 6 months of surveillance. The leading causes of death were measles, diarrhea, and acute respiratory infections. Surveillance data were used to institute changes in public health management including measles vaccination, vitamin A supplementation, and control programs for diarrhea and acute respiratory infections and to ensure rapid responses to cholera,<i>Shigella</i>dysentery, and meningoencephalitis. Within 4 months of establishing disease control interventions, crude mortality rates were reduced by 75% and were below emergency levels. <h3>Conclusions.</h3> —Simple, sustainable disease surveillance in refugee populations is essential during emergency relief efforts. Data can be used to direct communitybased public health interventions to control common infectious diseases and reduce high mortality rates among refugees while placing a minimal burden on health workers. (<i>JAMA</i>. 1994;272:377-381)
Miracle
Authors: Gary Pasternak
Journal: Annals of Internal Medicine (2010)

Ad Libitum15 June 2010MiracleGary Pasternak, MD, MPHGary Pasternak, MD, MPHFrom San Diego Hospice and The Institute for Palliative Medicine, San Diego, CA 92103.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-152-12-201006150-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail For MarilynI saw a woman who looked like yourounding the corner in her caras I stood waiting for the light to change.An unassuming, economical sedanI imagined you would drive.I caught a glimpse of her,enough to remind me of you,the short-cropped hair highlighted in soft tones,the graceful sweep of the neck,the high cheekbones suspending an effortless smile,the dignified yet humble posture,evident even as you sleep,and perhaps while walking or driving.that the riotous growth of weeds feeding in ... Author, Article, and Disclosure InformationAuthors: Gary Pasternak, MD, MPHAffiliations: From San Diego Hospice and The Institute for Palliative Medicine, San Diego, CA 92103.Current Author Address: Gary Pasternak, MD, MPH, 1260 Cleveland Avenue, #322, San Diego, CA 92103. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 June 2010Volume 152, Issue 12 Page: 823 Keywords Postural control Sleep Walking ePublished: 15 June 2010 Issue Published: 15 June 2010 Copyright & PermissionsCopyright © 2010 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
BAFF selectively enhances the survival of plasmablasts generated from human memory B cells
Authors: Danielle T. Avery, Susan L. Kalled, Julia I. Ellyard, Christine Ambrose, Sarah A. Bixler, Marilyn Thien, Robert Brink, Fabienne Mackay, Philip D. Hodgkin, Stuart G. Tangye
Journal: Journal of Clinical Investigation (2004)