tbuckley/cabot-search huggingface dataset:
Cardioplegic Strategies for Calcium Control
Authors: Yoshiaki Fukuhiro, Michelle Wowk, Ruchong Ou, Franklin Rosenfeldt, Salvatore Pepe
Journal: Circulation (2000)

Background —Ca 2+ overload plays an important role in the pathogenesis of cardioplegic ischemia-reperfusion injury. The standard technique to control Ca 2+ overload has been to reduce Ca 2+ in the cardioplegic solution (CP). Recent reports suggest that Na + /H + exchange inhibitors can also prevent Ca 2+ overload. We compared 4 crystalloid CPs that might minimize Ca 2+ overload in comparison with standard Mg 2+ -containing CP: (1) low Ca 2+ CP (0.25 mmol/L), (2) citrate CP/normal Mg 2+ (1 mmol/L Mg 2+ ), (3) citrate CP/high Mg 2+ (9 mmol/L Mg 2+ ), and (4) the addition of the Na + /H + exchange inhibitor HOE-642 (Cariporide). We also tested the effect of citrate titration in vitro on the level of free Ca 2+ and Mg 2+ in CPs. Methods and Results —Isolated working rat heart preparations were perfused with oxygenated Krebs-Henseleit buffer and subjected to 60 minutes of 37°C arrest and reperfusion with CPs with different Ca 2+ concentrations. Cardiac performance, including aortic flow (AF), was measured before and after ischemia. Myocardial high-energy phosphates were measured after reperfusion. The in vitro addition of citrate to CP (2%, 21 mmol/L) produced parallel reductions in Mg 2+ and Ca 2+ . Because only Ca 2+ was required to be low, the further addition of Mg 2+ increased free Mg 2+ , but the highest level achieved was 9 mmol/L. Citrate CP significantly impaired postischemic function (AF 58.3±2.5% without citrate versus 41.6±3% for citrate with normal Mg 2+ , P &lt;0.05, versus 22.4±6.2% for citrate with high Mg 2+ , P &lt;0.05). Low-Ca 2+ CP (0.25 mmol/L Ca 2+ ) significantly improved the recovery of postischemic function in comparison with standard CP (1.0 mmol/L Ca 2+ ) (AF 47.6±1.7% versus 58.3±2.5%, P &lt;0.05). The addition of HOE-642 (1 μmol/L) to CP significantly improved postischemia function (47.6±1.7% without HOE-642 versus 62.4±1.7% with HOE-642, P &lt;0.05). Postischemia cardiac high-energy phosphate levels were unaffected by Ca 2+ manipulation. Conclusions —(1) A lowered Ca 2+ concentration in CP is beneficial in Mg 2+ -containing cardioplegia. (2) The use of citrate to chelate Ca 2+ is detrimental in the crystalloid-perfused isolated working rat heart, especially with high Mg 2+ . (3) The mechanism of citrate action is complex, and its use limits precise simultaneous control of Ca 2+ and Mg 2+ . (4) HOE-642 in CP is as efficacious in preservation of the ischemic myocardium as is the direct reduction in Ca 2+ .
Misspelled Author Name
Authors: John Santelli, Ronald Bayer, Robert Klitzman
Journal: JAMA (2015)

municate with practitioners and each other about health and health care; such professionals also understand the importance of confidentiality in adolescent health care.State laws vary considerably on the health conditions for which adolescents can consent and on provisions allowing disclosure to parents. 1 In general, minor consent laws allow adolescents to seek health care on their own consent, protect confidentiality, and allow limited disclosure to parents.For example, New York State has provisions for confidential care for sexually transmitted diseases, human immunodeficiency virus infection, pregnancy, drug and alcohol dependency, and mental health problems, but no provisions covering family planning and abortion. 2,3Minor consent laws permit health care clinicians in New York to disclose certain information to parents (eg, mental health records under specific conditions) and prevent disclosure of other information (eg, records on abortion and sexually transmitted diseases treatment "may not be released to a parent or guardian"). 2,3 Nationally, state abortion laws covering minor adolescents often require notification or permission of parents unless the adolescent is judged by a court to be mature enough to consent herself.Objecting to such disclosure as a blanket legal requirement, the US Supreme Court has mandated a judicial bypass procedure in every state to prevent such blanket disclosure to all parents. 1 Given this complexity within and among states, legal principles and ethical standards from professional organizations provide guidance to health care practitioners in deciding what is best for their adolescent patients.Thus, 2014 statements from the Society for Adolescent Health and Medicine 4 and the American College of Obstetricians and Gynecologists 5 provide essential guidance on the confidential care of minor adolescents and in the design of EHR systems, which are frequently implemented in multiple states.Importantly, state minor consent laws allow a health care practitioner to disclose to parents certain information under limited conditions when, in the practitioner's judgment, such disclosure is prudent.The problem with current designs of EHRs is that they may force disclosure of an adolescent's confidential care without consulting the adolescent or the practitioner.That is what must be rectified.
Extreme hyperthermia after LSD ingestion
Authors: S. A. Friedman
Journal: JAMA (1971)

Hyperthermia is a known effect of lysergic acid diethylamide (LSD). This is, to our knowledge, the first recorded instance of life-threatening hyperthermia (106.4 F [41.3 C] axillary) in man, following the use of LSD, and may have been dose-related. The hyperthermia was rapidly reversed by alcoholic-ice soaks, hallucinations ended about 18 hours later, and the patient recovered without obvious mental or physical injury.
IDIOT SAVANTS, ARTISTS AND MUSICIANS.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Allergy and Immunology
Authors: James R. Baker
Journal: JAMA (1996)

Developments in our understanding of the regulation of the immune response highlight the past year's progress in the field of allergy and immunology. Three of the important topics include the genetic regulation of IgE production, Fas regulation of immune responses, and the control of TH1 and TH2 immune responses. High total serum IgE levels are known to correlate with allergies, asthma, and bronchial hyperresponsiveness. The observed familial aggregation of allergies and asthma has long supported the existence of an important heritable component to these conditions. As with most complex disorders, however, the allergic and asthmatic phenotypes do not seem to be inherited in simple Mendelian fashion. Furthermore, the clinical expression of these disorders is influenced by age, sex, and exposure to allergens, pollutants, and viral respiratory infections.<sup>1,2</sup>Consequently, the mode(s) of inheritance and the gene(s) responsible for these complex atopic disorders have been incompletely understood. Recent investigations into the
Impedance Plethysmography and DVT Diagnosis
Authors: Cedric J. Carter
Journal: Annals of Internal Medicine (1993)

Letters1 August 1993Impedance Plethysmography and DVT DiagnosisCedric J. Carter, MDCedric J. Carter, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-3-199308010-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In their recent article on the use of IPG for the management of clinically suspected DVT, Anderson and colleagues [1] report results of a retrospective study that greatly differs from previous prospective studies.The earlier prospective studies from McMaster University that compared IPG with obligate ascending venography for the diagnosis of DVT were done for the sole purpose of evaluating the accuracy of IPG [2]. The essential ongoing monitoring of the day-to-day quality of IPG is not possible with a retrospective study.The investigators from Holland [3] who examined the safety of serial IPG for the management ...References1. Anderson DR, Lensing AW, Wells PS, Levine MN, Weitz JI, Hirsh J. Limitations of impedance plethysmography in the diagnosis of clinically suspected deep-vein thrombosis. Ann Intern Med. 1993; 118:25-30. Google Scholar2. Hull RD, Raskob GE, LeClerc JR, Jay RM, Hirsh J. The diagnosis of clinically suspected venous thrombosis. Clin Chest Med. 1984; 5:439-44. Google Scholar3. Huisman MV, Buller HR, ten Cate JW, Vreeken J. Serial impedance plethysmography for suspected venous thrombosis. N Engl J Med. 1986; 314:823-8. Google Scholar4. Prandoni P, Lensing AW, Buller HR, Carta M, Vigo M, Cogo A. Failure of computerized impedance plethysmography in the diagnostic management of patients with suspected deep vein thrombosis. Thromb Haemost. 1991; 65:233-6. Google Scholar5. Lensing AW, Prandoni P, Brandjes D, Huisman PM, Vigo M, Tomassella G, et al. Detection of deep venous thrombosis by real-time B-mode ultrasonography. N Engl J Med. 1989; 320:342-5. Google Scholar Author, Article, and Disclosure InformationAuthors: Cedric J. Carter, MDAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1993Volume 119, Issue 3Page: 246-247KeywordsProspective studiesRetrospective studiesSafetySafety studies ePublished: 15 August 2000 Issue Published: 1 August 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Manual of Chemistry.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
“Terminal sedation” different from euthanasia, Dutch ministers agree
Journal: BMJ (2003)

Stress and infection and the risk of an exacerbationCertain types of psychological stress can suppress immune reactions, leading to an increased susceptibility to infections. 23This would confound the positive association we found between stress and exacerbations.However, we found no evidence of an increase in infections after stressful events in this study.Stress and infection were independently associated with the risk of exacerbation.It will not be easy to tackle these factors in individual patients, because infections and stressful events cannot simply be eradicated from patients' lives.The knowledge that stressful events are associated with disease activity adds important information to the limited insight that patients and their caregivers have on this unpredictable disease.We thank the late Monica van der Hoven, who performed secretarial and organisational tasks for this study, and to D Dippel for critical reading of the manuscript.
TOWARD AN EDITORIAL NEW STEADY STATE
Authors: J. R. E.
Journal: Annals of Internal Medicine (1961)

Editorials1 January 1961TOWARD AN EDITORIAL NEW STEADY STATEJ. R. E.J. R. E.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-54-1-159 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe editing of a journal (such as the ANNALS) lends itself to analogy with certain biologic processes. A healthy journal like a healthy organism is in a state of dynamic equilibrium. Output of energy must equal input of energy; randomness of effort must be diminished (less entropy), useful work must be done. The functional goal of the ANNALS organism, the useful work, has been presented already in an earlier editorial. Let us state it again: it is to help the physician to become a better physician by efficiently conveying to him stimulating ideas and useful knowledge.In terms of metabolic... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 January 1961Volume 54, Issue 1Page: 159-160KeywordsBiologics ePublished: 1 December 2008 Issue Published: 1 January 1961 PDF downloadLoading ...
ORAL HYGIENE.
Authors: GEORGE F. EAMES
Journal: JAMA (1902)

To secure a healthy condition of the human mouth and maintain it in that condition involves much, not only in the variety of methods by which this may be accomplished, but in its beneficent results, not alone to the oral cavity itself, but to the entire organism. These considerations may be classed under two heads, viz.: methods, and results. Let us first consider "results," that is, to put it in the form of a question, what results are desirable in order to secure the one grand achievement, a healthy mouth, the accomplishment of which underlies the whole practice of dentistry. As one of the first results, we may seek to obtain clean teeth, and by that we mean teeth that are clean—clean, not alone for the sake of their appearance, but with the object of improving their structure, of preventing decay, of invigorating adjacent tissues, and of securing the beneficial
Migraines may manifest as vertigo
Authors: J. McCann
Journal: JAMA (1982)

In the differential diagnosis of dizziness as a primary symptom, consider migraine. So says Peter Behan, MB, ChB, consulting neurologist at the University of Glasgow, Scotland, who has seen 32 patients in three years whose primary symptom was recurrent vertigo of such severity as to send them to bed. The diagnosis was confirmed in these patients when all responded to antimigraine medication, Behan told an international migraine symposium, which was part of the World Neurology Congress held in Kyoto, Japan. The mean age of the patients was 30 years, with a range from 8 to 65 years. Thirty of the patients had at least a 50% reduction in their attacks when treated with 1 mg of pizotyline three times per day. In the other two patients, propranolol hydrochloride was effective. All patients were followed up for up to three years. Behan told<i>JAMA</i>MEDICAL NEWS that the new agent pizotyline
Health Risks from Acid Rain: A Canadian Perspective
Authors: Claire A. Franklin, Richard T. Burnett, Richard J. P. Paolini, Mark E. Raizenne
Journal: Environmental Health Perspectives (1985)

Acidic deposition, commonly referred to as acid rain, is causing serious environmental damage in eastern Canada. The revenues from forest products, tourism and sport fishing are estimated to account for about 8% of the gross national product. The impact on human health is not as clearcut and a multi-department program on the Long-Range Transport of Airborne Pollutants (LRTAP) was approved by the federal government in June 1980. The objectives of the LRTAP program are to reduce wet sulfate deposition to less than 20 kg/ha per year in order to protect moderately sensitive areas. This will require a 50% reduction in Canadian SO2 emissions east of the Saskatchewan/Manitoba border and concomitant reductions in the eastern U.S.A. The objectives of the health sector of the program are to assess the risk to health posed by airborne pollutants which are subjected to long-range transport and to monitor the influence of abatement programs. Two major epidemiology studies were undertaken in 1983, one in which the health effects related to acute exposure to transported air pollutants were studied in asthmatic and nonasthmatic children, and another in which the effects of chronic exposure to these pollutants were studied in school children living in towns with high and low levels of pollutants. Preliminary analysis of the data do not indicate major health effects, but definitive conclusions must await final analysis. Studies on the indirect effects of acid deposition on water quality have shown that acidified lake water left standing in the plumbing system can adversely affect water quality and that federally set guidelines for copper and lead are exceeded. Flushing of the system before using the water rectifies the situation. Additional studies are planned to further delineate the magnitude of the health effects of acidified lake water.
The ancestral hemochromatosis haplotype is associated with a severe phenotype expression in Italian patients
Authors: A Piperno, C Arosio, S Fargion, A Roetto, C Nicoli, D Girelli, L Sbaiz, P Gasparini, G Boari, M Sampietro, C Camaschella
Journal: Hepatology (1996)

We evaluate the relation between genotype and phenotype in 47 Italian male patients with homozygous genetic hemochromatosis (GH). Phenotype evaluation was based on the ratio of amount of iron removed (IR) by phlebotomy and age (IR/age). Patients were divided in two classes of phenotype expression: class I included 26 patients with less severe iron overload (IR/age ≤0.33) and class II included 21 patients with a more marked one (IR/age &gt;0.33). Genetic variability was assessed by haplotype analysis combining alleles at HLA–B, D6S265, HLA–A, and D6S105 loci. A common ancestral haplotype carrying D6S265–1, HLA–A3, and D6S105–8 alleles was present in 13 of 52 (25%) chromosomes in class I and in 24 of 42 (57%) chromosomes in class II ( P = .0027). Homozygotes and heterozygotes for the ancestral haplotype had higher iron indices than patients carrying two haplotypes other than the ancestral one. Seven of the eight patients homozygous for the ancestral haplotype were in class II, heterozygotes were equally distributed between the two classes, whereas 14 of 18 carriers of other haplotype combinations were in class I. Our results suggests that the gene defect linked to the ancestral haplotype is the result of a single, severe mutation. The high variability of phenotype expression in heterozygotes for the ancestral haplotype could be accounted for the contribution of the mutation carried by the second haplotype. Combination of different mutations could be responsible for the variable degrees of iron overload found in patients with GH.
JAMA reference directories: state medical societies
Journal: JAMA (1978)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mechanistic Basis and Efficacy of Targeting β-Catenin-TCF7L2-JMJD6-MYC Axis to Overcome Resistance to BET Inhibitors
Authors: Christopher Peter Mill, Warren Fiskus, Dyana T. Saenz, Bernardo H Lara, Vrajesh Karkhanis, Taghi Manshouri, Isean Bhalla, Nancy Shao, James V Maher, Srdan Verstovsek, Kapil N. Bhalla
Journal: Blood (2019)
Statistical Methods for the Blood Beryllium Lymphocyte Proliferation Test
Authors: Edward L. Frome, Matthew H. Smith, L. Gayle Littlefield, Richard L. Neubert, Shirley P. Colyer
Journal: Environmental Health Perspectives (1996)

The blood beryllium lymphocyte proliferation test (BeLPT) is a modification of the standard lymphocyte proliferation test that is used to identify persons who may have chronic beryllium disease.A major problem in the interpretation of BeLPT test results is outlying data values among the replicate well counts (=7%).A log-linear regression model is used to describe the expected well counts for each set of Be exposure conditions, and the variance of the well counts is proportional to the square of the expected count.Two outlier-resistant regression methods are used to estimate stimulation indices (Sls) and the coefficient of variation.The first approach uses least absolute values (LAV) on the log of the well counts as a method for estimation; the second approach uses a resistant regression version of maximum quasi-likelihood estimation.A major advantage of these resistant methods is that they make it unnecessary to identify and delete outliers.These two new methods for the statistical analysis of the BeLPT data and the current outlier rejection method are applied to 173 BeLPT assays.We strongly recommend the LAV method for routine analysis of the BeLPT.Outliers are important when trying to identify individuals with beryllium hypersensitivity, since these individuals typically have large positive SI values.A new method for identifying large Sls using combined data from the nonexposed group and the beryllium workers is proposed.The log(SIl)s are described with a Gaussian distribution with location and scale parameters estimated using resistant methods.This approach is applied to the test data and results are compared with those obtained from the current method.