tbuckley/cabot-search huggingface dataset:
Dust Bath
Authors: Brian W. Christman
Journal: Annals of Internal Medicine (2018)

Ad Libitum20 November 2018Dust BathBrian W. Christman, MDBrian W. Christman, MDVanderbilt University, Nashville, Tennessee (B.W.C.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M18-0371 Audio Reading - “Dust Bath” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Dust Bath," by B.W. Christman. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The tanager was improbableBright red and blackAgainst the dry wheat grass of August.Graceful glide to a dry puddle patchWild fluffing and flappingAwkward so close to the earthGravity finally staking claimUnion with dust, lost birds ground fine,Joined with my patientsWho ploughed this groundTurned under old cropsBefore tucking in their ownWith green blankets of sodTo ward off the frost. Author, Article, and Disclosure InformationAffiliations: Vanderbilt University, Nashville, Tennessee (B.W.C.)Current Author Address: Brian W. Christman, MD; e-mail, brian.[email protected]gov. PreviousarticleNextarticle Advertisement Audio Reading - “Dust Bath” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Dust Bath," by B.W. Christman. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 20 November 2018Volume 169, Issue 10Page: 715KeywordsDust ePublished: 20 November 2018 Issue Published: 20 November 2018 Copyright & PermissionsCopyright © 2018 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Nephrology
Authors: John P. Hayslett
Journal: JAMA (1980)

The recent rapid growth of information related to renal disease, mechanisms of normal kidney function, and pathophysiological processes that cause altered renal function has resulted in several comprehensive textbooks, mostly written by authors from the United States. This book provides another attempt to review comprehensively the subject of nephrology by a group of eminent experts from the Hôpital Necker in Paris. Although reference is made to data derived from basic experimental studies, the authors have directed their book primarily toward clinical descriptions. The outline includes four sections. After a brief review of the basic anatomy, embryology, and physiology of the kidney, the second portion of the text is devoted to a description of the various syndromes and clinical manifestations that result from disturbances of renal function. The third and major portion of the book is concerned with a description of specific types of renal disease, including both primary renal disease
The Intubation
Authors: David P. Sklar
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
International Comments
Authors: Jean Hamburger
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AURAL AFFECTIONS IN BRIGHT'S DISEASE.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A1.68 An Acetyl-Histone MiMetic blocks inflammatory activation of rheumatoid arthritis fibroblast-like synoviocytes
Authors: P Kabala, A M Grabiec, N Smithers, J Witherington, P P Tak, R K Prinjha, K A Reedquist
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background and Objectives</h3> Genetic backgrounds do not completely explain the etiology of rheumatoid arthritis (RA), and increasing attention has turned to the potential contributions of epigenetic mechanisms. Fibroblast-like synoviocytes (FLS) isolated from affected joints of RA patients maintain an aggressive phenotype <i>in vitro</i>, indicating potential alteration of epigenetic regulatory processes, and changes in global and gene-specific promoter DNA methylation and histone modification are observed in RA FLS. I-BET compounds, acetyl histone mimetics which interfere with reading of acetylated histones by BET family bromodomain proteins BRD2-4, prevent LPS-induced inflammatory gene expression in murine bone marrow-derived macrophages <i>in vitro</i>, as well as <i>in vivo</i> models of endotoxic shock. This study was undertaken to assess the potential of I-BET to influence the inflammatory activation of RA FLS. <h3>Methods</h3> RA FLS were treated with IL-1β or TNF in the presence or absence of increasing concentrations of I-BET, and IL-6 and IL-8 production measured by ELISA. Cellular viability was assessed using MTT assay and cell death ELISA kits. Activation of intracellular signalling pathways was examined by immunoblotting. Total RNA was extracted and mRNA expression of genes regulated by IL-1β or TNF in RA FLS was analysed using a low density quantitative PCR custom array. <h3>Results</h3> I-BET reduced RA FLS (n = 6) production of IL-6 protein in response to IL-1β (1 μM, 70% reduction, P &lt; 0.001) and TNF (50%, P &lt; 0.001). IL-8 production in response to IL-1β (&gt;75% reduction, P &lt; 0.001) and TNF (&gt;70%, P &lt; 0.001) was also inhibited. Similar effects were observed on IL-6 and IL-8 mRNA expression. Inhibition of IL-6 and IL-8 production was maintained when I-BET treatment was delayed 1-4 hours post-stimulation. I-BET had no effect on cell viability or survival, and failed to modulate IL-1β or TNF–induced activation of MAPK or NF-κB signalling pathways. Low density qPCR array analysis of 26 genes induced by IL-1β in RA FLS (n = 3) demonstrated that I-BET reduced induction of 17 genes by &gt;50%, including TNF, MMP-1, MMP-3, SELE, VCAM-1, CXCL-6, CXCL-9 and CXCL-11. <h3>Conclusions</h3> Our results demonstrate that disrupting the recruitment of BET family proteins to acetylated histones efficiently blocks RA FLS production of a range of inflammatory mediators in response to IL-1β and TNF. This study provides initial evidence that targeting interactions between epigenetic modifications, such as histone acetylation, and the proteins which interpret these modifications, may have therapeutic potential in the treatment of RA.
Measurement of Ploidy and Cell Proliferation in the Rodent Liver
Authors: Jerry A. Styles
Journal: Environmental Health Perspectives (1993)

In most investigations of cell proliferation in vivo, the population under study consists of mononuclear diploid cells that undergo replication via normal complete division cycles.Because the phenomena associated with the cell cycle are sequential, only one is normally mea- sured and it is usually adequate to quantify the proliferative activity in one of two ways.The first involves labeling the cells undergoing semi-conservative DNA synthesis with a radioactive DNA precursor, preparing autoradiographs of histological sections, and counting labeled nuclei.The other commonly studied parameter of cell proliferation is mitotic activity.The liv- ers of rats and mice, unlike those of other mammals, consist mainly of hepatocytes that contain two classes of cell with respect to nuclei and several ploidy classes.These classes of hepatocytes arise as the result of modified cell division cycles.The peculiar cytological composition of the rodent liver has, until recently, caused difficulties in the measurement and interpretation of cell ploidy and cell proliferation by the above methods.Flow cytometry and fluorescence-acti- vated cell sorting used in conjunction with quantitative fluorescent stains for DNA and fluores- cently labeled antibodies to bromodeoxyuridine have permitted the rapid and precise quantifi- cation of cell proliferative activity in the rodent liver.Studies using these techniques have revealed that proliferative activity of hepatocytes may occur in different subpopulations of cells depending on the kind of toxicological injury inflicted on the animal.
Premature Ejaculation
Authors: Donald M. Marcus
Journal: JAMA (1963)

<h3>To the Editor:</h3> —A number of interesting comments have been received by the American Medical Association after my response to a question concerning premature ejaculation. To enlarge a bit on my previous comments, I want to say again that, in my experience, premature ejaculation rarely has an organic background. Nevertheless, I believe that if properly and carefully executed, a simple cystourethroscopic examination to exclude the possibility of a minimal inflammatory condition is most helpful. One of the greatest benefits is the satisfaction to the patient of knowing that the particular area was checked by the physician. Anxiety and tension of one cause or another form the usual background for the complaint of premature ejaculation or any of the other sexual imbalances. A failure in the act of intercourse may come from the most minimal cause and, if this fact is explained to and understood by the patient, there may be no continuing tension. However, in those individuals who are hypersensitive, and in those individuals not
ACLS
Authors: James M. Atkins
Journal: JAMA (1996)

<i>ACLS Review</i>by Mosby Lifeline is a computer-based CD-ROM review of advanced cardiac life support (ACLS). It is based on three Mosby Lifeline texts:<i>ACLS: A Comprehensive Review</i>and<i>ACLS: Certification Preparation</i>, both third editions by Grauer and Cavallaro, and<i>ACLS: Quick Review Study Guide</i>, by Aehlert. The accompanying pamphlet states that you need a 486SX25 with 4 MB RAM, SVGA/256 color display, a sound card (Soundblaster 16 or equivalent), and speakers and a double speed CD-ROM that are MPC 2-compliant. There is also a diskette version that will run on a 386SX25 with 2 MB RAM. The version used for this review was the CD-ROM version. It was run on a 486DX66 machine with 16 MB RAM and a 4-speed CD-ROM. There is no stated requirement for hard drive space; however, when loaded it created a directory that took up 26.9 MB. The first minor challenge was during
Lectures ON THE ANATOMICAL AND PHYSIOLOGICAL PRINCIPLES UNDERLYING THE TREATMENT OF INJURIES TO MUSCLES, BONES, AND JOINTS: Given at the Royal College of Surgeons of England, November-December, 1917
Authors: A. Keith
Journal: BMJ (1917)

From the above series of cases it would appear justifi- able to conclude that the treatment of thrombosis by this mletlhod does quickly arrest the process.Froin the patient's point of view tlle almost immediate rclease from pain was most gratifying.Th1e comiparison of a series of cases is always a dlifficult mwatter.To obviate tllis difficulty cases were treatedl alterniately by the two nietliods, and so may be con- sidered unselected.In reality the cases treated by the intravenous metilod wvere, on th-e whiole, the more serious.Anialysis ot the two groups slhows tlhat in thlose treated by thle intravenous mnethiod thle .subsequentperiod of pyrexia was sihorter by an average of four days anCd the onset of convalescence by an average of ten days than in those cases treated by the oral miethiod.Rleferenice to the table also shows thlat the average number of days, from thle onset of thirombosis to evacuation ini the cases trcat2d by the iatravenous miiethiod was thirtv days, whlile in thiose cases treated by the oral method it lvas thiirty-nine.It will, moreover.be nioted thiat, wbvereas in the series of seven cases treated by the intravenous method five--were evacuated as walkiing and two as sittin-gCases, and in one only was-there oedemia present on dis- clharge; in the oral series of ten cases, only five were evacuated as walking anid three as sitting cases, wllile two liad to be sent to England as stretclier cases, and in no fewer than five cases there was a considerable amount of oedema present on discharge.
THE ESOTERIC BEAUTY AND UTILITY OF THE MICROSCOPE.
Authors: EPHRAIM CUTTER
Journal: JAMA (1892)

IV. ASTHMATOS CILIARIS AND GRIP. Epidemic influenza, or grip, is not a new disease. To repeat, I am grateful to American microscopy for views of grip which are positive and tangible. One was once accused of jumping to conclusions too quickly and without sufficient investigation, and told that if he had an idea he ought to stick to it, develop it, and not sacrifice himself. Let us learn from critics and take a jump of fifteen years backwards to an observation. Fifteen years is not a too quick jump to make, and must be safe. June 20, 1877, I was in Cleveland, Ohio, studying the causes of disease with Dr. Salisbury. He had the grip, and showed me, under the microscope, in his excretions from the air passages (a), a dead infusorium he called asthmatos, and mentioned in Kent's Infusoria, page 466, and the Micrographic Dictionary, 1883, as a genus
Effect of Early and Late Feeding and Glucagon on Blood Sugar and Serum Bilirubin Levels of Premature Babies
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Book Review
Journal: JAMA (1980)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Recurrent Aphthous Stomatitis
Authors: Edward A. Graykowski
Journal: JAMA (1966)

Recurrent aphthous stomatitis (recurrent aphthae) is a disease of man characterized by painful, recurrent, single or multiple necrotizing ulcerations of mucosal tissues. The primary cause has not been established and there is no specific therapy. Several microbial agents have been incriminated, including herpes simplex and other viruses,<i>Toxoplasma</i>, the organisms which cause Vincent's angina, and other bacterial agents including the pleomorphic, transitional L-froms of an α-hemolytic streptococcus (<i>Streptococcus sanguis</i>) (see reviews for references<sup>1-3</sup>). Recurrence may be precipitated by trauma, hormonal changes in women, physical or psychic stress, and chemical irritants. The disease has been associated with allergic and genetic factors. Moreover, recurrent aphthae is often erroneously confused with herpes simplex infection and it may have clinical and histological aspects in common with Behcet's, Stevens-Johnson, and Reiter's syndrome. No less than 20 different synonyms have been used to characterize this disease.<sup>1-3</sup> To the practicing physician, the combined problems of
Specialty Abstracts
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hydrogenic Urticaria
Authors: Geza de Takats
Journal: JAMA (1964)

<h3>To the Editor:—</h3> The title, "Aquagenic Urticaria," used by Shelley and Rawnsley for their highly interesting paper(<i>JAMA</i><b>189:</b>895 [Sept 21] 1964), must evoke cholinergic urticaria in many of your readers. If Latin and Greek mixtures are to be avoided, "hydrogenic" would be the obvious adjective.
State of Research: Environmental Pathways and Food Chain Transfer
Authors: Burton E. Vaughan
Journal: Environmental Health Perspectives (1984)

Data on the chemistry of biologically active components of petroleum, synthetic fuel oils, certain metal elements and pesticides provide valuable generic information needed for predicting the long-term fate of buried waste constituents and their likelihood of entering food chains. Components of such complex mixtures partition between solid and solution phases, influencing their mobility, volatility and susceptibility to microbial transformation. Estimating health hazards from indirect exposures to organic chemicals involves an ecosystem's approach to understanding the unique behavior of complex mixtures. Metabolism by microbial organisms fundamentally alters these complex mixtures as they move through food chains. Pathway modeling of organic chemicals must consider the nature and magnitude of food chain transfers to predict biological risk where metabolites may become more toxic than the parent compound. To obtain predictions, major areas are identified where data acquisition is essential to extend our radiological modeling experience to the field of organic chemical contamination.