tbuckley/cabot-search huggingface dataset:
Use of Selected Toxicology Information Resources in Assessing Relationships between Chemical Structure and Biological Activity
Authors: John S. Wassom
Journal: Environmental Health Perspectives (1985)

This paper addresses the subject of the use of selected toxicology information resources in assessing relationships between chemical structure and specific biological end points. To assist the researcher in how to access the primary literature of genetic toxicology, teratogenesis, and carcinogenesis, three specific specialized information centers are discussed--Environmental Mutagen Information Center, Environmental Teratology Information Center, and Environmental Carcinogenesis Information Center. Also included are descriptions of information resources that contain evaluated (peer-reviewed) biological research results. The U.S. Environmental Protection Agency Genetic Toxicology Program, the International Agency for Research on Cancer Monographs, and the Toxicology Data Bank are the best sources currently available to obtain peer-reviewed results for compounds tested for genotoxicity, carcinogenicity, and other toxicological end points. The value of published information lies in its use. It has become evident that most information cannot be accepted at face value for interpretation and analysis when subjected to stringent quality evaluation criteria. This deficit can be corrected by rigid editorship and the cognizance of authors. Increased interest in alternative methods to in vivo animal testing will be exemplified by use of short-term bioassays and in structure-activity relationship studies. With respect to this latter area, it must be remembered that mechanically (computer generated) derived data cannot substitute, at least at this stage, for data obtained from actual animal testing. The future of structure-activity relationship studies will rest only in their use as a predictive tool.
Chemical and Biological Characterization of Emissions from Coal- and Oil-Fired Power Plants
Authors: M. Ahlberg, L. Berghem, G. Nordberg, S.-A. Persson, L. Rudling, B. Steen
Journal: Environmental Health Perspectives (1983)

Emission samples were obtained from two medium-sized power plants, one fired with oil and the other with pulverized coal. Particles obtained by a miniscale plume stack gas sampler (MIPSGAS), simulating the dilution process in the plume, were subjected to detailed physical, chemical and biological characterization. Studies by scanning electron microscopy and by Coulter counter demonstrated that the particles from the oil-fired boiler were considerably larger than the particles from the coal-fired boiler. Chemical analyses revealed more organic substances and more S, Ni, V, in the oil than in the coal particles. The latter contained a larger proportion of Al, Si, Cl, K, Ca, Ti, Mn, Fe, Se, Rb, Y, Zr, Ba and Pb. Biological testing revealed a greater acute and subacute toxicity by the intratracheal route in the hamster, a greater toxicity to alveolar macrophages and a greater lung retention of BaP coated on the particles from oil combustion than on those from coal combustion. In another sampling line, employed simultaneously with the MIPSGAS-particulate sampler, the total emissions were collected, i.e., both particle and gas phase. These samples were used for chemical analyses and Ames mutagenicity test. Analyses of specific PAHs in emissions from both plants demonstrated that concentrations were below the detection limit (less than 4 ng/m3 of benzo(a)pyrene), which is in accord with an efficient combustion of the fuel. The mutagenicity of the samples were below the detection limit of the mutagenicity assay.
INFLUENCE OF GLUCOSE AND NUCLEOSIDES ON THE RED BLOOD CELL IN STORAGE
Journal: JAMA (1961)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Twentieth Century Practice; an International Encyclopœdia of Modern Medical Science by leading Authorities of Europe and America.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Aims and Scope
Authors: Joe Tomaszewski
Journal: Medicinal Research Reviews (2016)

The journal publishes timely critical reviews of topics related to medicinal research, broadly defined, to which the authors have made significant contributions.Appropriate topics include, but are not limited to, the underlying pathophysiology of important diseases and disease vectors; therapeutic approaches to the treatment of various diseases; the properties of molecular targets for therapeutic agents; important new methodologies facilitating the search for therapies; genomics and proteomics; structure-activity correlations of drug series; the development of new imaging and diagnostic tools; drug metabolism; drug delivery; and chemical, pharmacological, pharmacokinetic, pharmacodynamic, and clinical characteristics of important drugs.Reviews are mainly solicited by the editors; however, voluntary contributions are also encouraged.In the latter case, potential authors are asked to contact the Editor-in-Chief with an outline before beginning to write in order to avoid duplication of effort and to ensure suitability of the topic and the level of coverage.
THE METRIC SYSTEM.
Journal: JAMA (1900)

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Medicolegal.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Announcement: Review Focus on New Insights into the Molecular Basis of Atrial Fibrillation: Mechanistic and Therapeutic Implications
Authors: Dobromir Dobrev, Stanley Nattel
Journal: Cardiovascular Research (2010)

A Review Focus Issue on atrial fibrillation is scheduled to appear in March, 2011.Atrial fibrillation is an area of enormous clinical relevance.Driven by this clinical importance, unmet therapeutic needs and rapid progress in basic research technology, enormous advances in understanding the molecular basis of the arrhythmia have occurred over the past few years.This Review Focus Issue will contain a number of important cutting-edge reviews addressing the role of genetic background, microRNA, atrial fibroblasts, key ion channels and the spatiotemporal organisation and dynamics of tissue conduction in arrhythmia development and the potential therapeutic implications.Preliminary topics of invited review articles related to the the molecular basis of atrial fibrillation include:
Reply:
Authors: Guilherme M. Campos
Journal: Hepatology (2008)

We appreciated the interest in our article1 and the insightful comments from Dr. Enzo Emanuele. We believe that routine use of the proposed NASH scoring system, which comprises variables readily available to clinicians when they evaluate morbidly obese patients, can facilitate clinical decisions and help clinicians choose and tailor treatment for morbid obesity, including bariatric surgery. We agree with Dr. Emanuele that many other biomarkers may indeed increase the diagnostic performance of the proposed NASH scoring system. Further clinical translational research, including cost analysis, is needed to better define diagnostic and therapeutic approaches to obesity and its associated diseases. Guilherme M. Campos M.D., FACS*, * Department of Surgery, University of California San Francisco, San Francisco, CA.
Misecellany.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE RÔLE OF THE LIVER IN HEMOPOIESIS
Authors: P. W. C.
Journal: Annals of Internal Medicine (1936)

ExcerptThe rôle of the liver in hemopoiesis has aroused increasing interest since the discovery by Minot and Murphy of the curative action of liver when fed to patients with pernicious anemia. It is now well established that liver contains some substance necessary for normal red cell production, which is produced in the normal body, but is lacking in pernicious anemia. A deficiency of this material results in an arrest of the maturation of the red blood cells and in the delivery into the blood stream of cells which are abnormal and functionally defective.The work of Cohn et al., of...
Beginning a career in pediatric hematology: 1926
Authors: M. I. Rhoads
Journal: JAMA (1988)

Since retiring, I've been asked several times what it was like when I went to medical school. Was it hard being a woman physician? How did you know you wanted to be a pediatrician? Why did you work with children who had cancer? And, since leukemia was surely a fatal disease at the time, why did you choose to work with those children? The answers to all these questions are complex and I have found them difficult to answer briefly. It was true that less than 10% of the freshman medical class of 1925 were women, but they were wonderful, lasting friends, as were many of the men. Medical school seemed no more difficult for the women in our class than for the men, who were always ready to do thoughtful things such as pith my frog in zoology or invite me to a class dance. How did I decide
Domestic Correspondence
Authors: Ed J Cleveland
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
利用一个位置扫描合成肽组合文库识别抑制黑色素合成的 小肽和甘氨酸胺
Authors: J.H. Kim, J.K. Seok, Y.M. Kim, Y.C. Boo
Journal: British Journal of Dermatology (2019)

黑色素是皮肤的自然颜色(或色素),可能会因为老化、激素、暴露在阳光下的紫外线、受伤、烧伤、痤疮或过敏引起的炎症而增加。色素沉着障碍(例如色素沉着)可导致不规则的暗斑皮肤,虽然这些疾病通常不会对身体造成伤害,但它们可导致严重的情绪困扰。多肽作为活性成分被越来越多地应用于护肤品中,并且抗黑素肽在治疗色素沉着方面具有潜在的应用价值。α‐黑素细胞刺激激素 (α‐ MSH) 是一种肽,它能够通过一系列复杂的事件,参与合成或产生黑色素。这项研究的作者旨在确定某些可以抑制这种由 α‐MSH 触发的黑色素合成的肽。如果能够找到这些肽,那么它就能阻止导致色素沉着等疾病中色素生成的生物事件级联。特别是,甘氨酸胺被发现能够抑制黑色素合成。作者目前正在进行这些肽的安全性和有效性的临床试验,并期望在治疗皮肤色素沉着方面取得突破。
The physician's oath and the prevention of nuclear war
Authors: C. K. Cassel
Journal: JAMA (1985)

ON NOV 15, 1983, a sentence was added to the text of the oath taken by physicians in the Soviet Union at the time of their graduation from medical school. The new sentence reads, "Recognizing the danger which nuclear weaponry presents for mankind, [I promise] to struggle tirelessly for peace, and for the prevention of nuclear war." While the role of physicians in educating the public and policymakers about the risks of the nuclear arms race and about the medical consequences of the use of nuclear weapons has been the subject of lively discussion and debate in the United States and in other countries during the last several years, this example of a call for professional responsibility in this area has gone largely unnoticed. While there are distinct differences in the perspective of the Soviet oath from that of physicians in the United States, we share with Soviet physicians an
BRAZIL
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Gene Delivery of IL-1Ra and Soluble TNF Receptor Confers a Distal Synergistic Therapeutic Effect in Antigen-Induced Arthritis
Authors: S KIM, E LECHMAN, S KIM, J NASH, T OLIGINO, P ROBBINS
Journal: Molecular Therapy (2002)

Intra-articular expression of antagonists of interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) in arthritic rabbit knee and mouse ankle joints by direct adenoviral-mediated intraarticular delivery results in amelioration of disease pathology in both the treated and contralateral untreated joints. Previous experiments suggest that direct adenoviral infection of resident antigen-presenting cells (APCs) and subsequent traveling of these cells to other sites of inflammation and lymph nodes might be responsible for this “contralateral effect.” To determine whether genetic modification of APCs is required for the contralateral effect, we have used an ex vivo approach utilizing genetically modified fibroblasts to express IL-1 receptor antagonist protein (IL-1Ra) and soluble TNF-α receptor (sTNFR) locally in arthritic joints. Retroviral vectors carrying IL-1Ra, sTNFR-Ig, or both genes together were used to stably infect autologous rabbit fibroblasts that were then injected intra-articularly into arthritic rabbit knee joints. The intra-articular delivery of either IL-1Ra- or sTNFR-Ig-expressing fibroblasts was antiinflammatory and chondro-protective in both the injected and noninjected contralateral joints. In addition, we demonstrate that the co-delivery of both antagonists in combination results in a synergistic effect in disease amelioration in both the treated and nontreated joints. These ex vivo results suggest that trafficking of vector-modified inflammatory cells is not the main mechanism responsible for the observed distal spread of the therapeutic effect. Moreover, the results demonstrate that local, ex vivo gene therapy for arthritis could be effective in blocking pathologies within untreated, distant arthritic joints.
OP 0717-0758
Authors: T Johannes, H Dieterich, K Unertl, C Ince, E Mik, C Ertmer, S Rehberg, M Lange, K Bröking, A Morelli, H Van Aken, E Rübig, F Von Roth, M Westphal, L Zoric, S Jaber, L Muller, B Jung, C Lebris, X Capdevilla, J Lefrant, J Lewejohann, D Wichmann, H Braasch, M Hansen, E Muhl, H Bruch, R Moreno, C Sprung, D Annane, D Keh, M Singer, J Briegel, K Freivogel, Y Weiss, J Benbenishty, A Kalenka, H Forst, P Laterre, K Reinhart, B Cuth- Berson, D Payen, H Schmidt, D Hoyer, M Rauchhaus, R Hennen, Y Daralammouri, K Pabst, K Hottenrott, U Mueller-Werdan, K Werdan, M Buerke
Journal: Intensive Care Medicine (2007)