tbuckley/cabot-search huggingface dataset:
Cor leopardum
Authors: S. Vaisrub
Journal: JAMA (1972)

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Abstract 387: Prolactin-Releasing Peptide, the Novel Endogenous Ligand of the Orphan Receptor GPR10, Regulates Cardiac Contractility
Authors: Attila Kónyi, Réka Skoumal, Anna-Maria Kubin, Iván G Horváth, Miklós Tóth, Lajos Papp, Heikki Ruskoaho, István Szokodi
Journal: Circulation (2007)

The hypothalamic prolactin-releasing peptide (PrRP), which is the endogenous ligand of the orphan receptor GPR10, plays an important role in the regulation of the central stress response, sleep regulation and feeding behavior. Although specific binding sites have been found in the rat myocardium, the functional importance of PrRP in the regulation of cardiovascular system is still unknown. The objective of the present study was to characterize the direct cardiac effects of PrRP as well as the underlying signaling mechanisms. In the isolated perfused, paced rat heart preparation (male 7-week-old, Sprague-Dawley rats, n=138), intracoronary infusion of PrRP-31 (1–30 nmol/L) for 15 min induced a dose-dependent, slowly developing positive inotropic effect, with a maximal increase in developed tension at the dose of 10 nmol/L (13.6%±3.1, P&lt; 0.001). Next we tested if various counter-regulatory mechanisms could modify the effect of PrRP. The phosphodiesterase inhibitor IBMX (10 μmol/L) failed to alter the inotropic response to PrRP (10.7±1.9%, P=N.S.) excluding the involvement of cAMP-dependent mechanisms. In contrast, the specific protein kinase C-alfa (PKC-alpha) inhibitor Ro32– 0432 (100 nmol/L) significantly increased the inotropic response to PrRP (21.6±3.4%, P&lt;0.05) as well as the phosphorylation of phospholamban at Ser-16 (1.5±0.09 vs. 1.0±0.18; P&lt;0.001) as measured by Western blotting. Moreover, the protein phosphatase (PP1/PP2A) inhibitor calyculin A (CyA) augmented the effect of PrRP on contractility (20.7 ±1.7%, P&lt;0.001) similarly to PKC-alpha inhibition, whereas the PP2A inhibitor okadaic acid (10 nmol/L) had no effect (7.8±1.0 %, P=N.S.). Furthermore, long-term (120 min) administration of PrRP resulted in a greater increase in contractility (20.3±3.1 %) as compared to short-term infusion (15 min; P&lt;0.05). Our results provide the first evidence for the functional significance of PrRP in the heart. The positive inotropic effect of PrRP is mediated via cAMP-independent mechanisms, which are suppressed by enhanced activity of PKC-alpha and PP1. We suggest that PrRP may play an important role in the long-term regulation of myocardial contractility.
Special Report of the New York State Commission to Formulate a Long Range Health Program on Health Mobilization for Defense
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SOME MEDICAL PROBLEMS CONCERNING IMMIGRATION.
Journal: JAMA (1890)

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Incorrect Percentage
Journal: JAMA (2020)

Michael E. Detsky, MD, MSHP; Naheed Jivraj, MBBS, MSc; Neill K. Adhikari, MDCM, MSc; Jan O. Friedrich, MD, MSc, DPhil; Ruxandra Pinto, PhD; David L. Simel, MD; Duminda N. Wijeysundera, MD, PhD; Damon C. Scales, MD, PhD
The effect of type of delivery on neonatal outcome in singleton infants of birth weight of 1,000 g or less
Authors: J. M. Barrett
Journal: JAMA (1983)

To evaluate the relationship between management of delivery and neonatal outcome in singleton neonates with birth weights between 501 and 1,000 g, a retrospective analysis was performed. In the 54-month period ending June 30, 1981, a total of 109 singleton neonates were born at Vanderbilt University Hospital, Nashville, Tenn, with birth weights between 501 and 1,000 g, 31 weighing 501 through 750 g, and 78 weighing 751 through 1,000 g. The overall neonatal survival rate was 60%, 39% in the group weighing 501 through 750 g and 69% in the group weighing 751 through 1,000 g. In terms of morbidity and mortality, there was no difference between neonates delivered by cesarean section compared with those delivered vaginally. The only significant factor found relating to neonatal mortality was the occurrence of labor. In the 17 newborns delivered without occurrence of labor, the frequency of neonatal death was significantly decreased, although this difference may be caused by differing risk factors in the infants delivered without occurrence of labor. When labor was present and the fetus had a cephalic presentation, cesarean section was not found to be superior to vaginal delivery in terms of neonatal morbidity or mortality for neonates of 1,000 g or less. (<i>JAMA</i>1983;250:625-629)
Author Index
Authors: K. O'Connor, C. Chambers, R. Hinchcliffe, C. van Heeringen, M. van Moffaert, G. de Cuypere, Myriam van Moffaert, Carol C. Nadelson, R.W. Trijsburg, J.A. Bal, W.P. Parsowa, R.A.M. Erdman, H.J. Duivenvoorden, Andres M. Kanner, Rachel G. Klein, Boris Rubinstein, Armond Mascia, Liisa Keltikangas-Järvinen, Katri Räikkönen, Nechama Weizer, Abraham Weizman, Zaki Shapira, Alexander Yussim, Hanan Munitz
Journal: Psychotherapy and Psychosomatics (1989)
Leads from the MMWR. Update: acquired immunodeficiency syndrome--Europe
Journal: JAMA (1985)

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JAMA Cardiology
Authors: Phil Fontanarosa, Annette Flanagin, Brenda Gregoline, Tracy Frey, Iris Lo, Kevin Brown, Amanda Ehrhardt, M Newman, Suzanne Walker, Connie Manno Senior, Sara Billings, Timothy Gray, Juliet Orellana, Paul Ruich, Kirby Snell, Catherine Alden, Stephanie Beckmeyer, Jane Calayag, Jan Clavey, Mary Coerver-Connolly, Paula Glitman, Laura King, Regina Lilly, Charon Pierson, Rebecca Ritke, Thressa Smith, Divya Sreekumar, Donna Thordsen, Christine Tilles, Caroline Woods, Editorial Assistant, Wanda Hill, Larry Bryant, Jacob Kendall-Taylor, Monica Managers, Fanny Staff, Anna Brown, Lee Bukowski, Lenette Calibeo, Tosca Gardner-Gullens, Erin Hall, Rachell Kato, Caroline Lozano, Angelia Sietmann, Michael Berkwits, Eric Butkus, Jesse Mcquarters, Elena Guobyte, Emily Ling, Daniel Morrow, Social Media, Eman Hassaballa, Reuben Rios, Mary Ferkaluk, Karen Bucher, Andy Rekito, Nick Reback, Lohitha Kethu, David Song, Deputy Livingston, Thomas Cole, Marla Hall, Deanna Willis, Yolanda Davis, Joseph Thornton, Deanna Bellandi, Jim Periodical, Thomas Easley, Brian Shields, Karen Adams-Taylor, Paul Gee, Monica Smith, Jeff Ery, J Bonistalli, Kathy Russell, Mirna Monal, Stacey Mchugh, Tim Melroy, Marketing Thornbury, Tricia Castellano, Anna Manager, Thalia Moss, Sade Deramus-Townsend, Tony Ralenkotter, Marsha Fogler, Rachel Sisholtz, Saskia Bolore, Gretchen Linder, Brian Mccartney, Christine Hearne, Natasha Staff, Henry Aguillon, David Baum, Ron Thomas, Rick Bell, Elizabeth Solaro, Sara Zimmerman, Geoff Rey, Lindsay Dawson, Ellen Gibson, Sam Ismail, Craig Mccaff Rey, Michael Mcgraw, Daniel Pickhardt, Romando Rossini, Sarah Subramanian, Stacy Business, Analyst Sirisha, Alluri Staff, Millette Jackson-Bates, Tom Miller, Morgan Osgood, James Madara, Howard Bauchner, Robert Bonow, Patrick O'gara, Marc Sabatine, Clyde Boston, Michael Pencina, Carolina North, Adrian Hernandez, Mhs Durham, North Carolina, Mark Huff Man, Ajay Kirtane, New York, Roxana Mehran, Ann Navar, Carolina Christopher, J O'donnell, Massachusetts Boston, J Sanjiv, Mintu Shah, Gregg Fonarow, Los Angeles, Elizabeth Mcnally, Laine Thomas, Akhil Narang, Julia Getts, Eugene Braunwald, Robert Califf, Judith Hochman, Donald Lloyd-Jones, Scm Chicago, Michael Parmacek, Daniel Simon, Sidney Smith, Chapel Hill, Carolina Douglas, E Vaughan, Myron Weisfeldt, Maryland Douglas, P Zipes, Paul Armstrong, Shinya Goto, Peter Liu, Renato Lopes, Carolina Maseri, Dorairaj Prabhakaran, Hugh Watkins, Harvey White, Habib Yacoub
Journal: JAMA Cardiology (2020)
Occurrence of Carcinoma in "Hot" Thyroid Nodules. Report of Two Cases
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mortality of a Cohort of Workers in the Styrene-Butadiene Polymer Manufacturing Industry (1943-1982)
Authors: Genevieve M. Matanoski, Carlos Santos-Burgoa, Linda Schwartz
Journal: Environmental Health Perspectives (1990)

A cohort of 12,110 male workers employed 1 or more years in eight styrene-butadiene polymer (SBR) manufacturing plants in the United States and Canada has been followed for mortality over a 40-year period, 1943 to 1982. The all-cause mortality of these workers was low [standardized mortality ratio (SMR) = 0.81] compared to that of the general population. However, some specific sites of cancers had SMRs that exceeded 1.00. These sites were then examined by major work divisions. The sites of interest included leukemia and non-Hodgkin's lymphoma in whites. The SMRs for cancers of the digestive tract were higher than expected, especially esophageal cancer in whites and stomach cancer in blacks. The SMR for arteriosclerotic heart disease in black workers was significantly higher than would be expected based on general population rates. Employees were assigned to a work area based on job longest held. The SMRs for specific diseases differed by work area. Production workers showed increased SMRs for hematologic neoplasms and maintenance workers, for digestive cancers. A significant excess SMR for arteriosclerotic heart disease occurred only in black maintenance workers, although excess mortality from this disease occurred in blacks regardless of where they worked the longest. A significant excess SMR for rheumatic heart disease was associated with work in the combined, all-other work areas. For many causes of death, there were significant deficits in the SMRs.
Assessment of Increase in Perinatal Exposure to HIV Among Hispanics—20 Counties, Georgia, 1994-2002
Journal: JAMA (2004)

CDC recently received reports from clinicians in a specialized pediatric human immunodeficiency virus (HIV) care clinic (clinic A) suggesting that the number of perinatally HIV-exposed Hispanic infants in the Atlanta metropolitan area had increased disproportionately to the growth of Hispanics in the area's population. To assess this increase and characterize trends in perinatal HIV exposure in this population, CDC collaborated with health-care providers at clinic A, which serves residents in 20 Georgia counties, including the Atlanta metropolitan area. This report summarizes the results of that assessment, which suggest that the increase in the number of perinatally HIV-exposed Hispanic infants was associated with multiple factors, including the growth of the Hispanic population, increasing HIV prevalence and fertility among Hispanics, and lower preconception awareness of HIV serostatus among those with HIV. The findings suggest a need for improved access to voluntary HIV counseling and testing and increased opportunities for reducing the risk for unintended pregnancy among Hispanics in these counties.
E. Brissaud, Lecons sur les Nerveuses (Saltpetriere 1893-1894) recuellies et publices.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction: Article on Vandetanib Inhibition of Growth of Adenoid Cystic Carcinoma in an Orthotopic Nude Mouse Model
Journal: Clinical Cancer Research (2008)

Article on Vandetanib Inhibition of Growth of Adenoid Cystic Carcinoma in an Orthotopic Nude Mouse ModelThe relevance of the findings reported in the article on vandetanib inhibition of growth of adenoid cystic carcinoma in an orthotopic nude mouse model in the August 15, 2008, issue of Clinical Cancer Research is now in question.The research reported was conducted on three cell lines that the authors believed to be adenoid cystic salivary carcinoma cell lines.Because of reports of cell line contamination after publication, they have since genotyped the three cell lines used in the article-ACC-2, ACC-3, and ACC-M-by short tandem repeat (STR) analysis, and this analysis revealed that all three lines had identical genotypes.On comparison to the genotypes of the ATCC cancer cell line collection, they found that their genotype was identical to that of HeLa cells.
BENIGN PARALOGICAL THINKING
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sensitivity of Health Endpoints: Effect on Conclusions of Studies
Authors: Edward P. Radford
Journal: Environmental Health Perspectives (1981)

The types of biological response to an environmental agent can depend on dose, thus in this case a family of widely different dose-response relationships would be expected. For those situations where the magnitude of the effect may be determined on probabilistic grounds as a function of dose ("stochastic" model), no particular dose-response relationship-may necessarily be inferred; the appropriate model still depends on the biological processes under consideration. Some examples of different conclusions concerning dose-response are given for studies of effects of lead and carbon monoxide at low doses. With increasingly sensitive measures of physiologic responses, these can be detected at exposures close to background, but for many cases the question remains whether an observed response really represents a true toxic effect. The application of epidemiologic data for regulatory purposes may depend on identification of the response to an agent appropriate for preventive measures. The conclusions one reaches about studies of health effects of environmental agents can be markedly influenced by the types of health endpoints under consideration.
Obesity Tax
Authors: Yasuo Ishida
Journal: JAMA (1973)

<h3>To the Editor.—</h3> Obesity is a major medical concern in the United States today. Despite all the clamor in and out of medical circles, there has been no definite step taken to solve this problem. It is obvious that there must be a strong incentive in order to lose weight. I hereby propose the establishment of an obesity tax (on a sliding scale, probably). After all, obese people take up more space! The money thus collected may be channeled into obesity research.
Teratological Research Using In Vitro Systems. IV. Cells in Culture
Authors: John J. Welsh
Journal: Environmental Health Perspectives (1987)

Several in vitro cellular systems designed to screen agents for teratogenic potential are described in this report. These assays were selected from a review of literature published through the spring of 1986 that generated over 100 references on teratological research using cell-based systems. Some of the assays have a broader application than others, but most require confirmation by one or more additional complementary tests because of the specificity of the teratogenic mechanism the assays are investigating. Included are systems that use analysis of tumor cell attachment; intercellular communication; growth of human embryonic palatal mesenchyme cells; progesterone production in porcine granulosa cells; differentiation of embryonic neural crest, limb bud, midbrain, and Drosophila cells; and differentiation of tumor cells. Because of the dynamic nature of cell culture work, the group of assays listed here should not be viewed as encompassing all cell systems of value with regard to teratogenicity testing; instead, the list represents several of the more prominent systems now being evaluated by the scientific community.
Manuscripts Approved for JNCI, June 1 to July 1, 1970
Journal: JNCI Journal of the National Cancer Institute (1970)

Journal Article Manuscripts Approved for JNCI, June 1 to July 1, 1970 Get access JNCI: Journal of the National Cancer Institute, Volume 45, Issue 2, August 1970, Pages 409–410, https://doi.org/10.1093/jnci/45.2.409-a Published: 01 August 1970