tbuckley/cabot-search huggingface dataset:
Environmental Influences on Uptake of Serotonin and Other Amines
Authors: Aron B. Fisher, Edward R. Block, Giuseppe Pietra
Journal: Environmental Health Perspectives (1980)

Lungs accumulate 5-hydroxytryptamine (serotonin, 5-HT) from the perfusate by a sodium-dependent, energy-requiring, saturable process. The rate-limiting step for uptake is the transport of 5-HT and not its subsequent metabolism to 5-hydroxyindoleacetic acid. Autoradiographic studies indicate that the pulmonary endothelium is the cellular site of uptake. The effect of hyperoxia on lung clearance of 5-HT was studied with isolated perfused and ventilated lungs from rats that were previously exposed to hyperoxia. Lungs were perfused with recirculating electrolyte solution and initial [5-HT] of 0.24 microM. The calculated fractional 5-HT clearance (fracion of 5-HT removed in a single pass) ws 0.77 +/- 0.02 (mean +/- SE: n = 44) for control rats. Mean fractional clearance decreased by 20% in rats exposed to 1 atm O2 for 18 hr and 30% after 4 atmospheres absolute (ata) O2 for 1 hr (p < 0.05). The effects of O2 at 4 ata were in part reversed by exposure to air for 3.5 hr and in part prevented by injection of superoxide dismutase (60 nmole/kg body weight). This degree of O2 exposure at either 1 or 4 ata had no effect on lung content of adenine nucleotides or the distribution of 3H-5HT on autoradiography. Rats maintained for 6 weeks on a vitamin E-deficient diet showed an increased effect of hyperoxia on 5-HT clearance and did not show reversal of changes after 24 hr of air breathing. The results indicate that exposure to elevatd po2 results in reversible depression of pulmonary 5-HT clearance that is potentiated by vitamin E deficiency. This suggests alteration of pulmonary endothelial membrane transport properties due to O2 toxicity.
Spectrum of β thalassemia mutations and their linkage to β‐globin gene haplotypes in the Indo‐Mauritians
Authors: Navaratnam Kotea, Rajendranath Ramasawmy, Chang Yong Lu, Nathalie Sem Fa, Nathalie Gerard, Sanjay Beesoon, Rolande Ducrocq, Soondal Koomar Surrun, Ronald L. Nagel, Rajagopal Krishnamoorthy
Journal: American Journal of Hematology (2000)

The β thalassemia alleles in 53 thalassemic Indo-Mauritian patients and their families consisting of 23 homozygous β-thalassemia, 9 HbE/β-thalassemia, 18 HbS/β-thalassemia, 1 HbD/β-thalassemia, 1 δβ/β-thalassemia and 1 HbH/β-thalassemia from the island of Mauritius were studied. Characterization by polymerase chain reaction-based reverse dot blot hybridization technique revealed that the IVS1-5 (G→C) mutation accounted for 74% of the β thalassemic alleles, while six other mutations occurred at much lower frequencies: HbE codon 26 (G→A); 10.4%, codon 8/9 (+G); 3.5%, codon 30 (AGG→ACG) also called IVSI (-1).G→C; 3.5%, codon 15 (G→A); 3.5%, codon 41/42 (−CTTT); 2.4% and -28 (A→G); 2.4%. Association of these mutations to specific β globin gene sequence framework and haplotype allowed to trace their ancestral link. These data are useful in future molecular screening of the population in view of implementing a thalassemia prevention and control program in Mauritius. Am. J. Hematol. 63:11–15, 2000. © 2000 Wiley-Liss, Inc.
A CENTURY'S ADVANCE IN PEDIATRY.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Analogy of Electronic Pacemaker and Ventricular Parasystole with Observations on Refractory Period, Super-normal Phase, and Synchronization
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THU0334 Severity of Diabetes Mellitus and Risk of Total Hip or Knee Replacement: A Population Based Case-Control Study
Authors: J.T.H. Nielen, B. van den Bemt, A. Lalmohamed, A. de Boer, A. Boonen, P.C. Dagnelie, P. Emans, F. de Vries
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> It is generally thought that people with diabetes mellitus (DM) are more likely to suffer from OA due to an increased Body Mass Index (BMI), resulting in the mechanical destruction of cartilage. However, previous studies have shown that DM could also be an independent risk factor for OA, suggesting other causative factors are involved (Nieves-Plaza M, 2013; Schett G, 2013). <h3>Objectives</h3> To evaluate the risk of hip or knee replacement, as a proxy for severe osteoarthritis (OA), in patients with diabetes mellitus (DM) compared to non-diabetic patients. We additionally evaluated the risk of total joint replacement (TJR) with various proxies for increased DM severity. <h3>Methods</h3> We performed a population based case-control study using the Clinical Practice Research Datalink (CPRD). Cases (n=94,609) were defined as patients &gt;18 years who had undergone TJR between 2000 and 2012. Controls were matched by age, gender and general practice. Conditional logistic regression was used to estimate the risk of total knee (TKR) and total hip replacement (THR) surgery associated with use of antidiabetic drugs (ADs). We additionally stratified current AD users by proxies for DM severity. <h3>Results</h3> Current AD use was significantly associated with a lower risk of TKR (OR=0.86 (95% CI=0.78-0.94)) and THR (OR=0.90 (95% CI=0.82-0.99)) compared to patients not using ADs. Moreover, risk of TKR and THR was decreased with increasing HbA1c. <h3>Conclusions</h3> In contrast to previous research, this study does not support the hypothesis that diabetic patients are more likely to suffer from severe OA as compared to non-diabetic patients. This is possibly due to methodological and medical dissimilarities between studies. <h3>References</h3> Nieves-Plaza M. Journal of Clinical Rheumatology, 2013; Schett G. Diabetes Care, 2013 <h3>Disclosure of Interest</h3> J. Nielen: None declared, B. van den Bemt Grant/research support from: Pfizer, Roche, Speakers bureau: Pfizer, Roche, Abbvie and MSD, A. Lalmohamed Grant/research support from: Netherlands Organisation for Scientific Research (NWO), A. de Boer: None declared, A. Boonen Grant/research support from: Amgen Abbvie, Pfizer and Merck, Speakers bureau: Pfizer, UCB and Sandoz, P. Dagnelie: None declared, P. Emans Grant/research support from: Stryker, Active implants, Carbylan Biosurgery, DSM Biomedical, Regentis, Speakers bureau: Biomet and Push braces, F. de Vries: None declared
Computer support helps GPs interpret family histories of cancer
Journal: BMJ (2000)

Cardioprotective value of aspirin in primary prevention is greater the lower the blood pressure In primary prevention, middle aged men at increased risk of coronary heart disease seem to benefit more from aspirin when systolic blood pressure is lower.The use of aspirin, often self prescribed, in those who have so far not experienced heart attacks requires careful consideration as only a few episodes will be prevented and even low doses of aspirin may carry an appreciable risk of potentially serious bleeding.The US physicians trial suggested that older men and those with low cholesterol concentrations would benefit most, but the UK thrombosis prevention trial (p 13) does not confirm these suggestions.The UK trial in 5499 men treated over nearly seven years showed that the risk of heart attacks was reduced by about half in those with lower blood pressures whereas there was little if any effect in those with higher pressures.These findings need to be confirmed or refuted, however, before they are taken as firm evidence in clinical practice.No link exists between blood transfusion and sporadic CJD
Lesions Induced in Rodent Pancreas by Azaserine and Other Pancreatic Carcinogens
Authors: Daniel S. Longnecker
Journal: Environmental Health Perspectives (1984)

Focal proliferative changes in the acinar cells of the pancreas of rats have been induced by several systemically administered carcinogens including azaserine, N-nitrosobis(2-oxopropyl)amine, N-nitroso-(2-hydroxypropyl) (2-oxopropyl)amine, and N delta-(N-methyl-N-nitrosocarbamoyl)-L-ornithine (MNCO). Foci, nodules, and adenomas induced by these carcinogens are usually made up of atypical-appearing acinar cells that maintain a high degree of differentiation, but a minority of these lesions exhibit anaplastic cellular changes that suggest the development of malignant potential. Such anaplasia may occupy the whole of smaller lesions or may occur as a secondary focal change within larger nodules or adenomas. Many foci and nodules per pancreas have been induced by single or multiple exposures to these known genotoxic carcinogens, but relatively few of them develop into carcinomas. Azaserine and MNCO have induced acinar cell carcinomas in rats. Those induced by azaserine have exhibited a broad spectrum of histologic variants, including ductlike cystic, and undifferentiated patterns. Higher doses of MNCO have induced a second pattern of change in the pancreatic lobules of rats, which includes cystic and tubular ductlike structures that have been called cystic and tubular ductal complexes. MNCO has also induced focal acinar cell lesions, cystic and tubular ductal complexes, and adenocarcinomas in the pancreas of Syrain golden hamsters. In this species, ductal complexes are much more numerous than are proliferative lesions of acinar cells, and the histologic appearance of the carcinomas is ductlike. Hyperplasia and atypical changes were also seen in the epithelium of the intralobular ducts of hamsters.(ABSTRACT TRUNCATED AT 250 WORDS)
Book Listings
Journal: Annals of Internal Medicine (2001)

Book Listings5 June 2001Book ListingsSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-134-11-200106050-00001 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Alternative MedicineAcupuncture: Efficacy, Safety and PracticeBritish Medical Association. 131 pages. Newark, NJ: Gordon and Breach/Harwood Academic; 2000. $24.00. ISBN 905823164X. Order phone 800-545-8398.Fundamentals of Complementary and Alternative Medicine2nd edition. MS Micozzi, ed. 464 pages. Philadelphia: WB Saunders; 2001. $49.00. ISBN 0443065764. Order phone 215-238-7800.Handbook of Religion and HealthHG Koenig, ME McCullough, and DB Larson. 712 pages. New York: Oxford Univ Pr; 2001. $65.00. ISBN 0195118669. Order phone 800-451-7556.Integrative Health Care: Complementary and Alternative Therapies for the Whole PersonVS Sierpina, ed. 396 pages. Philadelphia: FA Davis; 2001. $30.00. ISBN 0803607040. Order phone 800-323-3555.CardiologyAtherosclerosis: Gene Expression, ... Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 5 June 2001Volume 134, Issue 11Page: B1KeywordsBurnsComputed axial tomography ePublished: 5 June 2001 Issue Published: 5 June 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Treatment Alert Issued for Node-Negative Breast Cancer
Journal: JNCI Journal of the National Cancer Institute (1988)

Journal Article Treatment Alert Issued for Node-Negative Breast Cancer Get access JNCI: Journal of the National Cancer Institute, Volume 80, Issue 8, 15 June 1988, Pages 550–551, https://doi.org/10.1093/jnci/80.8.550 Published: 15 June 1988
Patient-doctor agreement about problems needing follow-up visit
Authors: B. Starfield
Journal: JAMA (1979)

In this study in an urban prepaid group practice, patients and practitioners agreed less than half the time as to what problems required follow-up at a subsequent visit. Problems that were mentioned by both practitioner and patient were much more likely to be followed up subsequently by the practitioner than problems initially mentioned only by the practitioner or only by the patient. Patients reported much more improvement of problems at follow-up when both practitioner and patient mentioned the problem as requiring follow-up than when they had been mentioned only by the patient. The involvement of patients in the process of care may be augmented by a variety of mechanisms. We believe greater patient participation in the processes of care should result in better follow-up of problems and better results, at least as perceived by patients. (<i>JAMA</i>242:344-346, 1979)
A Randomized Clinical Study of a Calcium-Entry Blocker (Lidoflazine) in the Treatment of Comatose Survivors of Cardiac Arrest
Authors: Brain Resuscitation Clinical Trial II Study Group
Journal: New England Journal of Medicine (1991)

Abnormalities of cellular calcium homeostasis have been implicated in the pathophysiology of postischemic encephalopathy. Calcium-entry—blocking drugs inhibit the influx of calcium into cells and have been shown to mitigate postischemic encephalopathy in animal models.
METHOD OF MAKING LANTERN SLIDES FROM ROENTGEN-RAY NEGATIVES
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medicolegal
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An Approach to the Determination of the Relative Potencies of Chemical Agents during the Stages of Initiation and Promotion in Multistage Hepatocarcinogenesis in the Rat
Authors: Henry C. Pitot, Harold A. Campbell
Journal: Environmental Health Perspectives (1987)

The potency of carcinogenic agents in eliciting neoplastic lesions has long been a concern of investigators in the field of oncology. This paper describes a method, based on quantitative stereologic calculations, to estimate the relative potency of chemicals as initiating and/or promoting agents. The parameters defined in this paper are: (a) Initiation index = no. foci induced X liver-1 X [mmole/kg body weight]-1; and (b) Promotion index = Vf/Vc X mmol-1 X wk-1. These parameters have been calculated for a number of chemical agents, based both on data from this laboratory and others published in the literature. Neither parameter varied significantly with the dose of two different initiating agents used in this study. The range of promotion indices extended over more than eight orders of magnitude, whereas that of the initiation indices was much less variable. Such parameters may be useful as quantitative estimates of the potency of hepatocarcinogenic agents not only in rodents, but potentially in quantitative risk estimations in the human.
Monoclonal antibodies: key to a revolution in clinical medicine
Authors: C. Macek
Journal: JAMA (1982)

Monoclonal antibodies, believed by many scientists to be the realization of Paul Ehrlich's decades-old "magic bullet" theory, are fast becoming the ammunition against a wide variety of diseases. The secretory products of cells called "hybridomas" (hybrid-myelomas), monoclonal antibodies are the final outcome of a laboratory manipulation whereby antibody-producing B lymphocytes (B cells) are fused with myeloma cells. The resulting hybrid cell line expresses the desirable characteristics of both parents: It produces antibodies of the same single specificity as the B cell and it is "immortalized" because of its cancerous parentage. The fusion technique would be unnecessary if nonmalignant B cells could be cloned and maintained in cell culture, but this has not been possible. Myelomas, on the other hand, synthesize antibody indefinitely, as evidenced by the quantity of Bence Jones protein in the urine of myeloma patients and in the supernates of myeloma cell cultures. The hybridoma technique was first
Studies From the Department of Pathology of the College of Physicians and Surgeons, Columbia University, New York.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Racers Contract<i>Campylobacter</i>Infection on Nevada Obstacle Course
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
<i>In Vivo</i> Characterization of Ftx-6058, a Novel Small Molecular Fetal Hemoglobin Inducer for Sickle Cell Disease
Authors: Keqiang Xie, Mark Roth, Ivan Efremov, Serena Silver, Lucienne Ronco, Lorin Thompson, Kim Stickland, Christopher Moxham, Owen Wallace
Journal: Blood (2020)
Ultrasonic Dosage
Authors: D. Gordon
Journal: BMJ (1965)

question his reference to " ' Bedlam Melancholia '-depressed patients so bad as to be willing to go and sit about for weeks in Bethlem," etc.There can be few general practitioners, whether depressed or not, who would not welcome the chance to sit about in Bethlem at present, with its individual bedrooms, squash court, heated swinmming-bath, lecture theatre-cum-cinema, the canteen in which to entertain one's friends, and the whole set in magnificent grounds, abounding in rhododendrons, woods, lawns, and fields.If in spite of these attractions one did wish just to sit about, pleasant quiet indoor facilities exist for this purpose too in the reading-room well supplied by the library, although the large, light, warm, and well-ventilated occupational unit could well provide a counter-attraction.I suggest that just as the depressed melan- cholic of twenty years ago is hardly to be seen now that E.C.T. is used, even more is the term " Bedlam melancholia " an anachro- nism to be deplored and hastily to be dropped from medical terminology.-Iam, etc.,