tbuckley/cabot-search huggingface dataset:
Blinded, Randomized, Multicenter Study to Evaluate Single Administration Pegfilgrastim Once per Cycle Versus Daily Filgrastim as an Adjunct to Chemotherapy in Patients With High-Risk Stage II or Stage III/IV Breast Cancer
Authors: F.A. Holmes
Journal: Journal of Clinical Oncology (2002)

PURPOSE: This multicenter, randomized, double-blind, active-control study was designed to determine whether a single subcutaneous injection of pegfilgrastim (SD/01, sustained-duration filgrastim; 100 μg/kg) is as safe and effective as daily filgrastim (5 μg/kg/d) for reducing neutropenia in patients who received four cycles of myelosuppressive chemotherapy. PATIENTS AND METHODS: Sixty-two centers enrolled 310 patients who received chemotherapy with docetaxel 75 mg/m2 and doxorubicin 60 mg/m2 on day 1 of each cycle for a maximum of four cycles. Patients were randomized to receive on day 2 either a single subcutaneous injection of pegfilgrastim 100 μg/kg per chemotherapy cycle (154 patients) or daily subcutaneous injections of filgrastim 5 μg/kg/d (156 patients). Absolute neutrophil count (ANC), duration of grade 4 neutropenia, and safety parameters were monitored. RESULTS: One dose of pegfilgrastim per chemotherapy cycle was comparable to daily subcutaneous injections of filgrastim with regard to all efficacy end points, including the duration of severe neutropenia and the depth of ANC nadir in all cycles. Febrile neutropenia across all cycles occurred less often in patients who received pegfilgrastim. The difference in the mean duration of severe neutropenia between the pegfilgrastim and filgrastim treatment groups was less than 1 day. Pegfilgrastim was safe and well tolerated, and it was similar to filgrastim. Adverse event profiles in the pegfilgrastim and filgrastim groups were similar. CONCLUSION: A single injection of pegfilgrastim 100 μg/kg per cycle was as safe and effective as daily injections of filgrastim 5 μg/kg/d in reducing neutropenia and its complications in patients who received four cycles of doxorubicin 60 mg/m2 and docetaxel 75 mg/m2.
Why clinicians are natural bayesians
Journal: BMJ (2005)

This is an observational study and may be subject to residual confounding.However, we think that enough concerns exist to warrant a reconsideration of the cardiovascular safety of all NSAIDs.We thank the EMIS practices contributing to QRESEARCH database and David Stables (EMIS Computing) and Mike Pringle for their help and expertise in establishing QRESEARCH.
XIII. PERTUSSIS VACCINE
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
LAWS REGULATING THE PRACTICE OF MEDICINE IN THE VARIOUS STATES AND TERRITORIES OF THE UNITED STATES.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Anatomy of the Human Eye and Orbit.
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Disorders of Voluntary Muscle
Authors: Kenneth R. Magee
Journal: JAMA (1970)

In the six years since the first edition of this text appeared, research and clinical interest in neuromuscular disease have burgeoned. Taking due note of the trend, Dr. Walton has extensively altered and modified the text for this edition, which is some 300 pages longer than the first. More attention is given to disorders of the anterior horn cell and peripheral nerve, and to studies involving tissue culture, ultrastructure, and experimental myopathy. Each of the 29 chapters provides a complete essay, and although this means that there is some duplication of certain aspects, good over-all balance is achieved between clinical studies and important basic work. The four major divisions of the book cover anatomy and physiology, pathology, clinical problems, and electrodiagnosis. Every section is informative and comprehensive, and each chapter carries a detailed bibliography of sources in the pertinent field. Inevitably this book will be compared with the other major
Hypertrophy of the Pyloric Muscle in Adults. An Analysis of 27 Cases
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Elevated creatine phosphokinase levels. Association with large muscle mass. Another pitfall in evaluating clinical significance of total serum CPK activity
Authors: W. Garcia
Journal: JAMA (1974)

A man with an exceptionally large muscle mass and a tentative diagnosis of acute myocardial infarction was found to have an elevated creatine phosphokinase (CPK) level. Subsequent diagnostic and clinical course was consistent with the conclusion that elevation of CPK level was due to his large muscle mass. Additional evidence for this conclusion was obtained by studying ten additional subjects with a similar body habitus. (<i>JAMA</i>228:1395-1396, 1974)
New Techniques Resculpt the Cornea
Authors: Rebecca Voelker
Journal: JAMA (1995)

INNOVATIONS in refractive surgery for myopes, hyperopes, and presbyopes bent on improving their vision are generating debate about the advantages of new laser techniques, as well as the potential for billions in revenue. Final Food and Drug Administration (FDA) approval last month of an excimer laser to treat nearsightedness by reshaping the cornea is expected to unleash a flood of consumer demand for photorefractive keratotomy (PRK). Patients who are farsighted, have other refractive errors, or just prefer an alternative to zapping away their myopia might choose insertable devices and lenses that also reshape the cornea or create a bifocal effect without the use of eyeglasses. "We're just entering the era where refractive surgery is becoming well accepted," said Richard Lindstrom, MD, medical director at Phillips Eye Institute Center for Teaching and Research in Minneapolis, Minn, during a Research to Prevent Blindness (RPB) science writers seminar in Orlando, Fla. Lindstrom, also
TYPHOID IMMUNIZATION
Authors: Louis Tuft
Journal: JAMA (1953)

<h3>To the Editor:</h3> —During the months of May and June many patients will ask their physicians about the advisability of typhoid revaccination for themselves or for their children. Need for this immunization has increased in recent years because, in instances in which children go to summer camps and adults spend their summers in foreign travel, exposure is much greater than usual. In both instances, typhoid vaccination is advised by health authorities. It seems to me, from personal experience and observation, that there is considerable confusion and misunderstanding in the minds of many physicians about the proper vaccination procedure. This is particularly true in respect to revaccination of previously immunized persons. I have found, for example, that some children and adults have been given three injections of the typhoid vaccine subcutaneously as soon as one or two years after the initial immunization. This is not only unnecessary but subjects these patients,
Children lose a devoted medical champion
Authors: P. Gunby
Journal: JAMA (1984)

A festschrift can be a tribute during life or it can be a memorial. The MarchAmerican Journal of Diseases of Childrenfestschrift to C. Henry Kempe, MD, has turned out to be both. Scarcely had the leader in pediatric medicine whom it honored received his copy—and expressed his pleasure and appreciation—when his life was claimed by the heart condition (complicated by respiratory problems) that had altered the pattern of the later years of his career. He died March 8 in Honolulu, where he and his wife, Ruth Svibergson Kempe, MD, had moved after Denver's mile-high altitude was found to be aggravating his condition. He would have been 62 this month. Kempe had gone to Denver in 1956 at the age of 34 from the University of California, San Francisco, School of Medicine—his alma mater—to be professor and chairman, Department of Pediatrics, at the University of Colorado School of Medicine.
Nephrotic State as the Chief Manifestation of Systemic Lupus Erythematosus
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Errors in Author Affiliations and Missing Degree
Authors: Steven Frucht, Michael Aminoff
Journal: JAMA Neurology (2018)

Daniel Martinez-Ramirez, MD; Joohi Jimenez-Shahed, MD; James Frederick Leckman, MD; Mauro Porta, MD; Domenico Servello, MD; Fan-Gang Meng, MD, PhD; Jens Kuhn, MD; Daniel Huys, MD; Juan Carlos Baldermann, MD; Thomas Foltynie, PhD, MRCP; Marwan I. Hariz, MD, PhD; Eileen M. Joyce, MD, PhD; Ludvic Zrinzo, MD; Zinovia Kefalopoulou, MD, PhD; Peter Silburn, MD; Terry Coyne, MD; Alon Y. Mogilner, MD, PhD; Michael H. Pourfar, MD; Suketu M. Khandhar, MD; Man Auyeung, MD, FHKCP, FHKAM; Jill Louise Ostrem, MD; Veerle Visser-Vandewalle, MD; Marie-Laure Welter, MD; Luc Mallet, MD, PhD; Carine Karachi, MD, PhD; Jean Luc Houeto, MD; Bryan Timothy Klassen, MD; Linda Ackermans, MD, PhD; Takanobu Kaido, MD, PhD; Yasin Temel, MD; Robert E. Gross, MD, PhD; Harrison C. Walker, MD; Andres M. Lozano, MD, PhD; Benjamin L. Walter, MD; Zoltan Mari, MD; William S. Anderson, MD; Barbara Kelly Changizi, MD; Elena Moro, MD, PhD; Sarah Elizabeth Zauber, MD; Lauren E. Schrock, MD; Jian-Guo Zhang, MD; Wei Hu, MD; Kyle Rizer, BS; Erin H. Monari, PhD; Kelly D. Foote, MD; Irene A. Malaty, MD; Wissam Deeb, MD; Aysegul Gunduz, PhD; Michael S. Okun, MD
Abstract 4599: PD-1/PD-L1 axis in cancer cells contributes to cellular EMT in lung adenocarcinoma
Authors: Wen-Pin Su, Li-Chan Chang, Jing-Jou Yan, Wu-Chou Su
Journal: Cancer Research (2019)

Abstract Background: Since intrinsic PD-1 receptor functions promote tumor growth was reported, we will investigate the role of PD-L1 in lung adenocarcinoma cells, and their impact on clinical outcome. Materials and methods: Lung adenocarcinoma CL1-5 cells, derived from CL1-0 cells have more invasive ability. We prepared PDL1-overexpression human lung adenocarcinoma cell line, derived from CL1-0 cells (CL1-0-PD1) and from PC14PE6 cells (PC14PE6-PD-L1). We observed the cellular morphology, and invasiveness; epithelial-mesenchymal transition (EMT) markers and regulators were also evaluated. To explore interaction between PD-1 and PD-L1, we treated the CL1-0, CL1-5, CL1-0-PDL1 cells, PC14PE6 cells, and PC14PE6-PD-L1 cells with anti-PD-1 antibody, and then evaluated cellular invasion. We also suppressed PD-1 to test whether PD-1/PDL-1 interaction contributed to the EMT change. Further, we evaluated cellular proliferation and chemosensitivity by MTT assay and colony formation assay. Finally, we correlated PD-L1 expression with clinical outcome in patients’ tumor specimen. Results: CL1-5 cells possessed higher PD-L1 expression than parental CL1-0 cells. CL1-0 cells with PD-L1 overexpression had more expression of EMT regulators and mesenchymal markers. Overexpression of PD-L1 in another lung adenocarcinoma PC14PE cells (PC14PE6-PD-L1 cells) become more aggressive. On the contrary, down-regulation of PD-L1 in CL1-5 cells and PC14-PE6-PD-L1 cells became indolent. Besides through the observation from confocal microscopy, PD-L1 expression was more co-localized with vimentin and slug, individually in CL1-5, CL1-0-PD-L1 and PC14PE6-PD-L1 cells. Therefore, PD-L1 promoted EMT in human lung adenocarcinoma cells. After adding anti-PD-1 antibody in CL1-5, CL1-0, and CL1-0-PDL1 cells, migration and invasion ability were decreased. Similar phenomenon was found when PD-1 antibody treatment in PC14PE6 cells, and PC14PE6-PD-L1 cells. Silencing PD-1 by siRNA also disrupt the cellular aggressivenss in CL1-0-PD-L1 and PC14PE6-PD-L1 cells. These results indicated PD-1/PD-L1 axis regulated cancer cells migration and invasiveness. PD-L1 expression also decreased cellular proliferation and had little influence on chemsensitivity. Finally, we found that higher PD-L1 expression was correlated with lymph node metastasis in clinical specimen. Conclusion: Lung adenocarcinoma cells with higher PD-L1 expression promote EMT via PD-1 receptor. PD-L1 expression lowers proliferation rate, but has little impact on chemosensitivity. Lung cancer patients with high PD-L1 expression in tumor have higher lymph node metastasis. Citation Format: Wen-Pin Su, Li-Chan Chang, Jing-Jou Yan, Wu-Chou Su. PD-1/PD-L1 axis in cancer cells contributes to cellular EMT in lung adenocarcinoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4599.
ENURESIS IN CHILDHOOD.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Double-blind study of metaxalone; use as skeletal-muscle relaxant
Authors: S. Diamond
Journal: JAMA (1966)

Patients with an acute skeletal-muscle spasm frequently pose a considerable problem to the practitioner who must deal with these spastic conditions. Conservative treatment in the form of rest, heat, analgesics, and guarded activity often reduce the reflex muscle spasm. However, most patients prefer to remain active for one reason or another and hence they seek medical attention for the purpose of shortening the acute phase of the disease. Skeletal-muscle spasm or muscular splinting may be considered to be a persistent, painful, and reversible contracture of striated muscle, usually localized to an area of trauma, inflammatory disease, or other pathological process not amenable to voluntary control. Psychogenic factors such as anxiety, tension, and emotional stress can accentuate as well as be the precipitating cause of acute skeletal-muscle spasm. The "tension" headache in which muscle contraction plays a prominent role is a prime example.<sup>1</sup> Since the introduction of mephenesin, an interneuronal
The Great Physician: A Short Life of Sir William Osier
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ORIGINAL INVESTIGATIONS ON THE NATURAL HISTORY, (SYMPTOMS AND PATHOLOGY) OF YELLOW FEVER. 1854-1894.
Authors: JOSEPH JONES
Journal: JAMA (1895)

<h3>Chapter VII.</h3> Lungs: The lungs in the dependent portions were greatly congested with blood, and presented a mottled purplish and red appearance. The lower portions of the lungs, when cut, resembled the congested lungs of pneumonia, and in circumscribed portions effusions of blood had taken place. The muscular structures of the thorax, when cut and exposed to the atmosphere, presented a brilliant scarlet hue, like those of patients poisoned with cyanid of potassium. Abdominal cavity: Alimentary canal, exterior surface of stomach somewhat congested. Internal mucous membrane of a deep purplish and brownishpurple and red color, with variations in the depth of the color, presenting a mottled appearance. Under low magnifying powers, suitable for the examination of the mucous membrane of the stomach by direct light, an intense congestion of the capillaries and small blood vessels was observed. In some places the epithelium of the mucous membrane of the stomach had