Intermittent Positive Pressure Breathing Therapy of Chronic Obstructive Pulmonary Disease
Journal: Annals of Internal Medicine (1983)

Article1 November 1983Intermittent Positive Pressure Breathing Therapy of Chronic Obstructive Pulmonary DiseaseA Clinical TrialAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-99-5-612 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail AbstractAbstractA multicenter trial compared intermittent positive pressure breathing (IPPB) therapy with compressor nebulizer therapy in 985 ambulatory patients with chronic obstructive pulmonary disease. A bronchodilator aerosol solution was administered with both treatments, the only difference being the positive pressure applied by IPPB. Patients were randomly assigned to treatment and closely followed by monthly home and quarterly clinic visits for an average of 33 months. Compliance with treatment, lung function, and quality of life were evaluated at regular intervals during follow-up, and records were kept of hospitalizations and vital status. Treatment compliance was disappointing; only half of the patients used their devices the prescribed amount of time. There was no statistically significant difference between the treatment groups in mortality, rate and duration of hospitalizations, or change in lung function or life quality with time, overall or for clinically relevant subgroups. We saw no advantage of IPPB over compressor nebulizer therapy in this large group of patients, and conclude that, if an advantage exists, it must be marginal.References1. . Protocol for Intermittent Positive Pressure Breathing Collaborative Program. Bethesda, Maryland: National Institutes of Health; 1978. Google Scholar2. MAYCOCK R. IPPB is a useful modality in the treatment of obstructive lung disease, in: INGLEFINGER FJ, EBERG RV, FINLAND M, RELMAN AS, eds. Controversies in Internal Medicine. Philadelphia: W. B. Saunders; 1974:249-62. Google Scholar3. MILLERHEPPER RN. 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BAKER, M.D. 1 November 1983Volume 99, Issue 5Page: 612-620KeywordsBloodBreathingChronic obstructive pulmonary diseaseHeartHeart diseasesHospitalizationsLungsNeuropsychologyQuality of lifeRespiratory system procedures ePublished: 1 December 2008 Issue Published: 1 November 1983 Copyright & Permissions©1983 American College of PhysiciansPDF downloadLoading ...