tbuckley/cabot-search huggingface dataset:
Abstract 3660: Cardioprotective Effect of Eicosapentaenoic Acid, an Important Fish Oil, through Suppression of Endothelin-1-induced Cardiomyocyte Hypertrophy via PPAR-α
Authors: Nobutake Shimojo, Subrina Jesmin, Masaaki Soma, Seiji Maeda, Takashi Miyauchi, Kazutaka Aonuma
Journal: Circulation (2007)

A growing body of evidences report the cardiovascular benefit of fish oil including eicosapentaenoic acid (EPA) in humans and experimental animals. While many studies link EPA to cardiac protection, the effect of EPA on endothelin (ET)-1-induced cardiomyocyte hypertrophy is unknown. On the other hand, the previous study demonstrated peroxisomal proliferator-activated receptor (PPAR) -α ligand (fenofibrate) prevents ET-1-induced cardiomyocyte hypertrophy. Though EPA is one of the lignads of PPAR-α, there was no study linking relationship between EPA and PPAR-α on hypertrophied cadiomyocyte. The present study investigated whether ET-1-induced cardiomyocyte hypertrophy could be prevented by the pre-treatment of EPA. Cardiomyocytes were accumulated from neonatal rat heart, cultured and at day 4 of culture, the cardiomyocytes were divided into three groups: control, ET-1 (0.1nM) treated and EPA-pre-treated (10μM) ET-1 groups. A 90% increase in cardiomyocyte surface area, a 75% increase in protein synthesis rate and an elevated actinin expression in cardiomyocyte were observed after ET-1 administration and these changes were greatly prevented by EPA pre-treatment. ET-1-induced hypertrophied cardiomyocytes showed a 2.3-fold and 2.1-fold increase in ANP and BNP mRNA expression, respectively, which were also suppressed by EPA pre-treatment. Pre-treatment of EPA could also attenuate phosphorylated JNK (an important component of MAPK cascade), c-Jun and PPAR-α in ET-1-induced hypertrophied cardiomyocytes. In conclusion, the present study showed that ET-1 can induce significant hypertrophic changes in cardiomyocytes with upregulation of important hypertrophic markers, and that this remodeling was effectively prevented by the pre-administration of EPA through suppressing PPAR-α, phosporylated JNK, and c-Jun.
ACTING ASSISTANT SURGEON U. S. A.
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Traumatic Hemobilia
Authors: Paul T. Souliotis, Ann H. Pettigrew, John W. Chamberlain
Journal: New England Journal of Medicine (1963)

THE clinical entity of traumatic hemobilia was first recognized by Sandblom1 in 1948. He coined the term to denote bleeding into the biliary system secondary to liver trauma, and likened this condition to traumatic hematuria resulting from kidney injury. Such an injury to the liver must produce communication between blood vessels and bile ducts in a closed space so that egress of bile, blood and liver fragments occurs through the outflow biliary tree. Hemorrhage through the biliary tract has been reported in a number of liver diseases,2 3 4 but traumatic hemobilia is relatively rare. We have found only 27 documented cases . . .
Euthyroid Hyperthyroxinemia
Authors: GERHARD BAUMANN
Journal: Annals of Internal Medicine (1983)

Letters and Corrections1 July 1983Euthyroid HyperthyroxinemiaGERHARD BAUMANN, M.D.GERHARD BAUMANN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-99-1-126_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The article by Borst and coworkers (1) on euthyroid states accompanied by elevated serum thyroxine (T4) levels lists several conditions where the elevated total T4 is due to abnormal binding of T4 to serum proteins. In these conditions, free T4 is normal. The classic example for this type of discrepancy is an altered thyroxine-binding globulin (TBG) concentration. Increased T4 binding to albumin or thyroxine-binding prealbumin (TBPA) as a cause for elevated total T4 has only recently been identified.The free T4 index, based on total T4 and resin triiodothyronine (T3) uptake, is a widely used laboratory test...References1. BORSTEILBURMAN GCK. Euthyroid hyperthyroxinemia. Ann Intern Med. 1983;98:366-78. LinkGoogle Scholar2. CLARKHORN FD. Assessment of thyroid function by the combined use of the serum protein-bound iodine and resin uptake of 131I-triiodothyronine. J Clin Endocrinol Metab. 1965;25:39-45. CrossrefMedlineGoogle Scholar3. ROBINHAGENCOLLACOREFETOFFSELENKOW NSFSH. Serum tests for measurement of thyroid function. Hormones. 1971;2:266-79. MedlineGoogle Scholar4. REFETOFFHAGENSELENKOW SSH. Estimation of the T4 binding capacity of serum TBG and TBPA by a single T4 load ion exchange resin method. J Nucl Med. 1972;13:2-12. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Northwestern University Medical School Chicago, Ill 60611 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1983Volume 99, Issue 1Page: 126-127KeywordsAlbuminsAttentionGlobulinsHyperthyroxinemiaLaboratory testsSerum proteinsThyroxineTriiodothyronine Issue Published: 1 July 1983 PDF DownloadLoading ...
Career mobility in allied health education
Authors: J. W. Perry
Journal: JAMA (1969)

So much has been said about the concept of career mobility and so little has been done to implement this concept that we are immediately faced with the simple questions: Is the idea of "career mobility" fiction or fact? Is it a philosophical fable or can it be translated into reality? In the brief time that I have, I would like to examine some of the needs for career mobility; some of the factors which might make it work: a few of the attempts already in operation; and finally, where do we go from here? This may sound more like the outline for a book than for a 20-minute speech, but it gives you an idea of the breadth of this much-discussed subject. The idea of "career ladder" has come into prominence at a time when health education and health professionals are attempting to answer the dilemma of the century:
THE STATE REGISTRATION OF NURSES
Authors: J. A. Coutts
Journal: BMJ (1909)

<h3>Summary and Conclusions</h3> Toluidine blue (TB) and methylene blue MB exert against <i>R. orientalis, in vitro</i>, only a slight rickettsiacidal effect, which is independent of light or oxygen. Treatment with TB or MB of mice infected with <i>R. orientalis</i> impedes the localization and multiplication of rickettsiae in the brain, causes a diminution in the infectivity of the blood, and results in an inconstant inhibition of rickettsial multiplication in the liver. However, maximal tolerated doses of dye do not prevent small infecting doses of rickettsiae from initiating an immunizing infection; greater, eventually lethal, amounts of dye do not exert a completely suppressive effect; and, finally, great prolongation of treatment (a total of 65 days) does not sterilize the tissues. As a corollary observation, a strain of rickettsiae recovered after the prolonged treatment shows no evidence of having become fast to MB. As shown by limited histopathologic observations, MB largely prevents the development of the anatomic lesions of scrub typhus but, presumably secondary to its destructive effect upon red cells, does exert a marked stimulus to hemopoietic activity. As noted by other workers, treatment with MB is effective against experimental murine typhus. In mice receiving such treatment, however, no inhibition of rickettsial multiplication in the liver is demonstrable. In addition to TB and MB, six structurally related compounds, azure C, azure A, brilliant cresyl blue, azure B, thionin blue, and selenium methylene blue, also are effective in combatting rickettsial infections. In contrast, an additional and greater number of related compounds appear to possess no such activity. The foregoing evidence does not permit definite conclusions to be drawn regarding the mode of action of TB and MB in combatting rickettsial infections. It is suggested that the mechanism is independent of the <i>in vitro</i> rickettsiacidal activity of the dyes and is only partly dependent upon the irregular rickettsiostatic effect observed <i>in vivo</i>. An additional possibility is that the dyes also operate to spare the cells from the usual harmful effects produced by the rickettsiae by virtue of their ability to mediate intracellular oxidation. A survey of related compounds further indicates that antirickettsial activity requires some degree of structural specificity.
“Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort.” Dominick E. Shaw, Ana R. Sousa, Stephen J. Fowler, Louise J. Fleming, Graham Roberts, Julie Corfield, Ioannis Pandis, Aruna T. Bansal, Elisabeth H. Bel, Charles Auffray, Chris H. Compton, Hans Bisgaard, Enrica Bucchioni, Massimo Caruso, Pascal Chanez, Barbro Dahlén, Sven-Erik Dahlen, Kerry Dyson, Urs Frey, Thomas Geiser, Maria Gerhardsson de Verdier, David Gibeon, Yi-ke Guo, Simone Hashimoto, …
Journal: European Respiratory Journal (2017)
Cluster of HIV-Positive Young Women—New York, 1997-1998
Journal: JAMA (1999)

As of July 1997, six human immunodeficiency virus (HIV) infections in young women who reported sexual contact with the same HIV-infected man (putative index case-patient) were detected at health-service clinics in a rural county in upstate New York. During the next several months, other sexual contacts of the man were discovered by public health officials through routine voluntary partner notification interviews, interviews with exposed women, and after a public announcement resulted in counseling and testing of approximately 1400 persons in the county. This report presents epidemiologic and laboratory findings of the young women investigated as part of this cluster and suggests a common source of HIV infection for these women.
Commentary: Hormone-Associated Cancer: Mechanistic Similarities between Human Breast Cancer and Estrogen-Induced Kidney Carcinogenesis in Hamsters
Authors: Joachim G. Liehr
Journal: Environmental Health Perspectives (1997)

Estrogens are risk factors for human breast cancer and induce kidney tumors in Syrian hamsters.Mechanistic features of the estrogen-induced hamster kidney tumor model have been compared with corresponding aspects of human breast cancer to gain insight into the mechanism of human mammary oncogenesis.Shared characteristics point to a mechanism of metabolic activation of steroidal estrogens to 4-hydroxylated catechol metabolites that may undergo metabolic redox cycling, a mechanism of generation of reactive free radicals.Tumors may arise in cells genetically altered by various types of estrogen-induced DNA damage.At the same time, these altered cells may respond to estrogen receptor-mediated stimuli in support of cell transformation and growth.Environ Health Perspect 1 05(Suppl 3):565-569 (1997) Key words: estradiol, breast cancer, estrogen
The treatment of gonococcal proctitis. An evaluation of 173 patients treated with 4 g of spectinomycin
Authors: N. J. Fiumara
Journal: JAMA (1978)

A group of 1,533 homosexual males were examined in 1976 for gonorrhea at the Skin Clinic of the Boston Dispensary. This examination included a rectal culture. There were 213 males with positive rectal cultures: an infection rate of 13.7%. Of these, 173 were treated with 4 g of spectinomycin hydrochloride, intramuscularly, and 127 (73.4%) returned in one week for a posttreatment examination and culture. All who returned had a negative culture. Four grams of intramuscular spectinomycin hydrochloride appears to be effective in the treatment of gonococcal proctitis. (<i>JAMA</i>739:735-737, 1978)
British Academy of Psychopharmacology
Authors: D. Wheatley
Journal: BMJ (1974)

prednisolone twice daily.At no time did he receive any sulphonamide preparation.While on this dosage of prednisolone he re- ceived, in October 1973, an injection of 1 ml of Admune subcutaneously, which he had had in the previous year.Within 10 days he began to suffer from myalgia, which affected all muscle groups, and arthralgia.His weight began to fall and this was asso- ciated with general malaise and anorexia.Clinical examination was unhelpful apart from a maintained pyrexia of 38-39°C and generalized muscle wasting.Investigations showed a haemoglobin of 11-0 g/100 ml; E.S.R. 33 mm in 1 hr; serum electrolytes and urea normal; W.B.C. 22,000/mm3 with 6,300 eosinophils/mm'; serum creatinine phosphokinase 17 mU/ml; antinuclear factor negative; L.E. cells
Overdistension of the gastric balloon. Complication with the Sengstaken-Blakemore tube
Authors: M. D. Nickell
Journal: JAMA (1978)

HEMORRHAGE from gastric or esophageal varices often necessitates the use of a Sengstaken-Blakemore tube for variceal tamponade. Although complications may occur with its use, safety and effectiveness following proper placement and monitoring have been demonstrated in 91% of patients.<sup>1,2</sup>We report a case of overinflation of the Sengstaken-Blakemore gastric balloon while following optimal recommended inflation and pressure monitoring techniques. <h3>Report of a Case</h3> A 51-year-old woman was admitted to Fitzsimons Army Medical Center with upper gastrointestinal hemorrhage from esophageal varices confirmed by emergency esophagogastroduodenoscopy. A new Sengstaken-Blakemore tube with Boyce<sup>1</sup>modification was inflated and inspected under water to ensure competency of both esophageal and gastric balloons and was then inserted through the mouth without difficulty. The gastric balloon was filled with 100 ml of air, and firm traction was applied on the tube at the mouth to position the gastric balloon against the diaphragm at the gastric cardia. An
Improved effectiveness of partner notification for patients with sexually transmitted infections: systematic review
Journal: BMJ (2007)

Objective To examine the effectiveness of methods to improve partner notification by patient referral (index patient has responsibility for informing sex partners of their exposure to a sexually transmitted infection).Design Systematic review of randomised trials of any intervention to supplement simple patient referral.Data sources Seven electronic databases searched (January 1990 to December 2005) without language restriction, and reference lists of retrieved articles.Review methods Selection of trials, data extraction, and quality assessment were done by two independent reviewers.The primary outcome was a reduction of incidence or prevalence of sexually transmitted infections in index patients.If this was not reported data were extracted according to a hierarchy of secondary outcomes: number of partners treated; number of partners tested or testing positive; and number of partners notified, located, or elicited.Random effects meta-analysis was carried out when appropriate.Results 14 trials were included with 12 389 women and men diagnosed as having gonorrhoea, chlamydia, nongonococcal urethritis, trichomoniasis, or a sexually transmitted infection syndrome.All studies had methodological weaknesses that could have biased their results.Three strategies were used.Six trials examined patient delivered partner therapy.Metaanalysis of five of these showed a reduced risk of persistent or recurrent infection in patients with chlamydia or gonorrhoea (summary risk ratio 0.73, 95% confidence interval 0.57 to 0.93).Supplementing patient referral with information for partners was as effective as patient delivered partner therapy.Neither strategy was effective in women with trichomoniasis.Two trials found that providing index patients with chlamydia with sampling kits for their partners increased the number of partners who got treated.Conclusions Involving index patients in shared responsibility for the management of sexual partners improves outcomes.Health professionals should consider the following strategies for the management of individual patients: patient delivered partner therapy, home sampling for partners, and providing additional information for partners.
THERAPEUTIC USE OF THE OXYGEN CHAMBER
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Three Scenes
Authors: Laura Kunberger
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Heparin (Continued)
Authors: Daniel Banes
Journal: JAMA (1974)

<h3>To the Editor.—</h3> The official<i>United States Pharmacopeia</i>monograph on heparin sodium provides an assay for standardizing the potency of the drug by comparing its capacity to prolong the clotting time of blood with that of USP sodium heparin reference standard. Protamines are not involved in this assay. The<i>USP</i>monograph further provides purity tests to preclude contaminating proteins, extraneous nitrogen content, pyrogens, and excessive acidity or alkalinity, volatile substances, and residue on ignition. Moreover,<i>USP</i>requires that the manufacturer label the product to indicate the organ and species from which it is derived. If improved standards, assay methods, purity tests, or labeling safeguards are available to enhance the clinical utility and efficiency of heparin sodium,<i>USP</i>should be pleased to receive explicit recommendations buttressed by verified scientific data.
The Approach to Cardiology
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Equivalence of thyroid preparations
Journal: JAMA (1980)

<h3>To the Editor.—</h3> In the report on nonequality of brand name T<sub>4</sub>products by Jacobson et al, the rather dramatic differences in bioavailability as measured by the mean T<sub>4</sub>concentration and free T<sub>4</sub>index between Levothroid and Synthroid have not been shown in various studies we have done using both patients and healthy volunteers. In 1965 to 1966, we did a series of comparison studies using Levothroid and Synthroid. Seventy-five hypothyroid patients were treated with either preparation and maintained at a clinically euthyroid state for at least one month. At that time, determinations of protein-bound iodine (PBI) and serum triiodothyronine (T<sub>3</sub>) uptake were done. Each patient then had therapy with the alternative brand at the same dosage given for at least one month, at which time the two laboratory determinations were again due. The results showed a mean PBI value in patients treated with Levothroid to