tbuckley/cabot-search huggingface dataset:
Infectious Mononucleosis
Authors: S. Varadi
Journal: BMJ (1958)

<b>Objectives:</b> To establish injury rates among a population of elite athletes, to provide normative data for psychological variables hypothesised to be predictive of sport injuries, and to establish relations between measures of mood, perceived life stress, and injury characteristics as a precursor to introducing a psychological intervention to ameliorate the injury problem. <b>Methods:</b> As part of annual screening procedures, athletes at the Queensland Academy of Sport report medical and psychological status. Data from 845 screenings (433 female and 412 male athletes) were reviewed. Population specific tables of normative data were established for the Brunel mood scale and the perceived stress scale. <b>Results:</b> About 67% of athletes were injured each year, and about 18% were injured at the time of screening. Fifty percent of variance in stress scores could be predicted from mood scores, especially for vigour, depression, and tension. Mood and stress scores collectively had significant utility in predicting injury characteristics. Injury status (current, healed, no injury) was correctly classified with 39% accuracy, and back pain with 48% accuracy. Among a subset of 233 uninjured athletes (116 female and 117 male), five mood dimensions (anger, confusion, fatigue, tension, depression) were significantly related to orthopaedic incidents over the preceding 12 months, with each mood dimension explaining 6–7% of the variance. No sex differences in these relations were found. <b>Conclusions:</b> The findings support suggestions that psychological measures have utility in predicting athletic injury, although the relatively modest explained variance highlights the need to also include underlying physiological indicators of allostatic load, such as stress hormones, in predictive models.
Modern Advances in Diseases of the Throat
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Symposium on the Behaviour of Tritium in the Environment
Journal: JNCI Journal of the National Cancer Institute (1978)

Symposium on the Behaviour of Tritium in the Environment Get access JNCI: Journal of the National Cancer Institute, Volume 60, Issue 4, April 1978, Page 935, https://doi.org/10.1093/jnci/60.4.935-c Published: 01 April 1978
Measuring the improving quality of outpatient care in medical oncology practices in the United States.
Authors: Michael N. Neuss, Jennifer Malin, Stephanie Chan, Pamela Kadlubek, John L. Adams, Jacobson Joseph, Douglas Blayney, Joseph V. Simone
Journal: Journal of Clinical Oncology (2012)

66 Background: The American Society of Clinical Oncology (ASCO) Quality Oncology Practice Initiative (QOPI) has provided a method for measurement of process based practice quality since 2006. We sought to determine whether QOPI participants show improvement in measured quality over time, and if change is demonstrated, those factors in either the measures or participants which are associated with change. Methods: 156 participant medical practice groups, which did not submit trainee data, participated in at least two collection rounds from 2006 through 2010, and reported on ≥30 patients per round from were included in analysis from a larger group of 306 participants from this time period. A database of these reports was used to evaluate trends in scoring among participants. A linear regression model, which controlled for varied initial performance, was used to estimate the effect of participation over time and evaluate participant and measure characteristics. Measures were aggregated into categories to evaluate which factors correlated with change. Results: Participants completed a mean of 5.71 (S.D. 1.84) rounds of data collection. Adjusted mean quality scores improved from 0.71 (95% C.I. 0.42 – 0.91) to 0.85 (95% C.I. 0.60 – 0.95). Overall odds ratio of improvement over time was 1.09 (p &lt; 0.0001). The greatest improvement was seen in measures assessing newly introduced clinical information, where the mean scores improved from 0.05 (95% C.I. 0.01 – 0.17) to 0.69 (95% C.I. 0.33 – 0.91), (p ≤ 0.0001). Many measures showed no change over time. Conclusions: QOPI has gained widespread adoption and approximately 15% of U.S. medical oncologists participate. Participation over time is highly correlated with improvement in measured performance. Much of this improvement is the result of the adoption of newly introduced clinical information. Some measures show no change despite significant opportunity for improvement.
Chromium deficiency during total parenteral nutrition
Authors: H. Freund
Journal: JAMA (1979)

Chromium is required for maintenance of normal glucose tolerance. After complete bowel resection and five months of total parenteral nutrition, severe glucose intolerance, weight loss, and a metabolic encephalopathylike confusional state developed in a patient. Serum chromium levels were at the lowest normal level. Supplementation of 150 μg of chromium per day reversed the glucose intolerance, reduced insulin requirements, and resulted in weight gain and the disappearance of encephalopathy. The low levels of chromium and response to chromium supplementation suggest that chromium deficiency can arise in long-term total parenteral nutrition. (<i>JAMA</i>241:496-498, 1979)
Schistosomiasis
Authors: Adel A. Mahmoud
Journal: New England Journal of Medicine (1977)

Schistosomiasis, one of the more important worm infestations of mankind, is widely distributed over three continents, affecting more than 200 million people, and is often associated with considerable morbidity. Unlike almost all other parasitic infestations, schistosomiasis is increasing in prevalence as man attempts to use water and land resources more efficiently. The development of many countries in Africa and South America depends on the construction of new dams and the initiation of irrigation projects, which provide ideal breeding places for the snail host of the parasite. Schistosomiasis is therefore a challenge not only for physicians and scientists but also for . . .
In Brief
Journal: JNCI Journal of the National Cancer Institute (2006)

Low-Fat Diet Not Associated With Reduced Risk of Breast, Colorectal CancerA low-fat diet is not associated with a reduced risk of colorectal cancer or breast cancer, according to a randomized controlled trial of nearly 50,000 women.International comparison studies have suggested that countries with a lower dietary fat intake have reduced risks of colorectal cancer and breast cancer.The Women's Health Initiative (WHI) Dietary Modifi cation Trial was designed to test whether a low-fat diet reduces the rate of colorectal cancer, breast cancer, and heart disease in 48,835 postmenopausal women aged 50 -79 years.About 20,000 of the women were randomly assigned to intensive dietary instruction to increase their fruit, vegetable, and grain consumption.They used self-monitoring techniques and other strategies to reduce fat intake to about 20% of total daily calorie intake.These women were not specifi cally instructed to lose weight.The control group of women were told to maintain their usual diet.Researchers diagnosed colorectal cancer at a rate of 0.13% a year in the group of women on a low-fat diet and a rate of 0.12% per year in the control group.They diagnosed breast cancer at a rate of 0.42% a year in the group of women on a low-fat diet and a rate of 0.45% a year in the control group.These differences were not statistically signifi cant.The low-fat diet also had no effect on the incidence of cardiovascular disease, coronary heart disease, or stroke.The researchers note that few women were actually able to reduce fat intake to 20% of total calories: Only 31% met that goal after 1 year and 14% did after 6 years.Nevertheless, the women in the dietary intervention group did consume a lower-fat diet and ate on average one more serving of fruits and vegetables per day than the control group.
Ethical Considerations in Resuscitation
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Assessment and determinants of aesthetic discomfort in hand osteoarthritis
Authors: Bridget Hodkinson, Emmanuel Maheu, Mathilde Michon, Fabrice Carrat, Francis Berenbaum
Journal: Annals of the Rheumatic Diseases (2011)

Background Dissatisfaction with hand appearance is frequently the presenting complaint of patients with hand osteoarthritis (HOA), yet no tool exists for its measurement and few studies have examined aesthetic discomfort. Objectives The aims of this study were to measure the extent and to explore the associations of aesthetic concerns in HOA. Methods 172 patients with HOA were assessed with tender joint and node count, global and pain scores, Functional Index for Hand Osteoarthritis, Short Form-12, Hospital Anxiety and Depression Scale and posterior–anterior hand radiographs. Patients scored the aesthetic impact of the disease on a Visual Analogue Scale of 0–100 mm and were classified into low, intermediate and high aesthetic concern (HAC) based on this score. Results Of 172 patients (155 women), the majority (92%) had nodes and 46% had erosive disease. The mean aesthetic score was 44.8 mm (SD 35.9), and 59 (34.3%) patients scored their aesthetic discomfort ≥66 mm. Factors associated with HAC were female gender, a high number of tender joints and nodes, high global and pain scores, high radiological damage scores, the presence of erosions and high depression and anxiety levels. The multivariate analysis identified two independent factors associated with HAC: patient's global assessment (p=0.0005) and radiographic erosions (p=0.03). Conclusions Aesthetic discomfort is a major concern for a significant number of patients with HOA, particularly women, those with a high burden of HOA disease and those with erosive osteoarthritis, and is also associated with depression, anxiety and poor health-related quality of life.
Peptic Ulceration
Authors: I. E. D. McLean
Journal: BMJ (1947)

applicability or otherwise of your editorial comments to our work in this part of the world.It may also be of interest to your readers to know how the condemned policy actually works in the Pacific.Compulsory isolation of lepers in Fiji started in 1911 with the estab- lishment of a small " asylum " on the recently purchased island of Makogai.Up to the end of 1946, 738 patients, or over 25% of the 2,845 admissions, had been discharged as "arrested" (having shown no sign of leprotic activity for at least 2 years) in addition to 436 " improved " patients, many of whom would have undoubtedly gone on to " arrest " under continued treatment but who were repatriated to India at their own request.In a comparative study utilized in my handbook on Makogai, published in 1944, and reviewed in your columns, I pointed out
Abstract B41: Mutant U2AF1 alters hematopoiesis and pre-mRNA splicing in transgenic mice.
Authors: Cara Lunn Shirai, James N. Ley, Brian White, Justin Tibbitts, Jin Shao, Matthew Ndonwi, Sanghyun Kim, Theresa Okeyo-Owuor, Timothy A. Graubert, Matthew J. Walter
Journal: Clinical Cancer Research (2015)

Abstract This abstract is being presented as a short talk. A full abstract is printed in the Proffered Abstracts section (PR06) of the Conference Proceedings. Citation Format: Cara Lunn Shirai, James N. Ley, Brian White, Justin Tibbitts, Jin Shao, Matthew Ndonwi, Sanghyun Kim, Theresa Okeyo-Owuor, Timothy A. Graubert, Matthew J. Walter. Mutant U2AF1 alters hematopoiesis and pre-mRNA splicing in transgenic mice. [abstract]. In: Proceedings of the AACR Special Conference on Hematologic Malignancies: Translating Discoveries to Novel Therapies; Sep 20-23, 2014; Philadelphia, PA. Philadelphia (PA): AACR; Clin Cancer Res 2015;21(17 Suppl):Abstract nr B41.
Notes on Micro-organisms Pathogenic to Men.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Analysis of Mitotic Nondisjunction with Aspergillus nidulans
Authors: G. Morpurgo, D. Bellincampi, G. Gualandi, L. Baldinelli, O. Serlupi Crescenzi
Journal: Environmental Health Perspectives (1979)

Two methods to detect the induction of nondisjunction with a diploid stable strain of A. nidulans are described. The first method gives only qualitative results, while the second method is quantitative and dose-effect curves can be done. Some physiological parameters affecting the induction of nondisjunction can also be studied, because either quiescent or germinating conidia can be treated with the drug under test. Some agents inducing nondisjunction were also tested for the induction of point mutation and somatic crossing-over with these comparative analysis. Two classes of agents inducing nondisjunction may be detected: the first causes all possible types of genetic damage either on quiescent or germinating conidia (a representative of this class is MMS) and acts presumably on the DNA level; the second acts only on germinating conidia and does not produce point mutation or crossing over. A representative of this class is Benomyl which interferes with spindle microtubules. A list of compounds tests is included.
Genetic Polymorphisms and Breast Cancer Risk
Authors: Vahe A. Kazandjian
Journal: JAMA (1997)

<h3>To the Editor.</h3> —Western medicine is at a crossroads regarding the understanding of health and disease. Indeed, the discovery of genetic predisposition to diseases previously believed to be primarily "caused" by exposure is changing our appreciation of multifactorialism. Increasingly, biomedical scientists are compelled to learn more about the patient to understand the disease and to appreciate the patient's culture in order to prescribe the acceptable path toward healing the ailment. In short, the discovery of oncogenes may have transformed Western medicine from a disease management doctrine to a social science, perhaps revisiting the nature vs nurture conundrum. And in that transformation medicine may have rediscovered a concept common to many cultures— the concept of destiny. That a person's<i>N</i>-acetyltransferase 2 (NAT2) profile increases susceptibility to breast cancer is a proposition similar to those derived from other potential correlations discovered in the past few years between genetics and incidence of
Projections of AIDS morbidity and mortality in San Francisco
Authors: G. F. Lemp
Journal: JAMA (1990)

To develop a model for predicting acquired immunodeficiency syndrome (AIDS) morbidity in San Francisco, Calif, through June 1993, we combined annual human immunodeficiency virus seroconversion rates for homosexual and bisexual men and for heterosexual intravenous drug users with estimates of the cumulative proportion of the population with AIDS by duration of human immunodeficiency virus infection and with estimates of the size of the at-risk populations. We projected AIDS mortality by applying Kaplan-Meier estimates of survival time following diagnosis to the projected number of cases. The median incubation period for AIDS among homosexual and bisexual men infected with the human immunodeficiency virus was estimated to be 11.0 years (mean, 11.8 years; 95% confidence interval, 10.6 to 13.0 years). The model projects 12 349 to 17 022 cumulative cases of AIDS in San Francisco through June 1993, with 9966 to 12 767 cumulative deaths. (<i>JAMA</i>. 1990;263:1497-1501)
Prevalence of Self-Reported Postpartum Depressive Symptoms—17 States, 2004-2005
Journal: JAMA (2008)

Postpartum depression (PPD) affects 10%-15% of mothers within the first year after giving birth. Younger mothers and those experiencing partner-related stress or physical abuse might be more likely to develop PPD. CDC analyzed data from the Pregnancy Risk Assessment Monitoring System (PRAMS) for 2004-2005 (the most recent data available) to 1) assess the prevalence of self-reported postpartum depressive symptoms (PDS) among mothers by selected demographic characteristics and other possible risk factors for PDS and 2) determine factors that identify mothers most likely to develop PPD. This report summarizes the results of that analysis, which indicated that, during 2004-2005, the prevalence of self-reported PDS in 17 U.S. states ranged from 11.7% (Maine) to 20.4% (New Mexico). Younger women, those with lower educational attainment, and women who received Medicaid benefits for their delivery were more likely to report PDS. State and local health departments should evaluate the effectiveness of targeting mental health services to these mothers and incorporating messages about PPD into existing programs (e.g., domestic violence services) for women at higher risk.
Reply
Authors: Bart J. Veldt, Harry L. A. Janssen
Journal: Hepatology (2008)

We thank Drs. Zhong and Yang for their reaction to our article. They comment that the Ishak score may not adequately represent the degree of hepatic damage. As we discussed in our article, there may indeed be a range for true severity of cirrhosis within Ishak stage 6. Therefore, we corrected our multivariate model for other markers of advanced liver disease, such as bilirubin, albumin, and platelet count. Khan et al. previously showed that fibrosis score, sporadic transmission, and level of serum albumin and bilirubin—and not alanine aminotransferase or alpha-fetoprotein—were the most important predictors of hepatocellular carcinoma and liver-related death among chronic hepatitis C patients.1 Drs. Zhong and Yang also raise the question whether the carcinogenic effect of hepatitis C virus (HCV) might be partly explained by metabolic abnormalities induced by HCV. Indeed, we think that it is possible that part of the carcinogenic effect of HCV is mediated by metabolic abnormalities induced by the virus.2, 3 If this hypothesis is true, improving insulin sensitivity by exercise, weight loss, or insulin-sensitizing agents might help to protect against the development of hepatocellular carcinoma. These potential effects should be investigated in prospective studies. Because sustained virologic response has been shown to be associated with a decreased risk of developing diabetes mellitus, achieving sustained virologic response may be the best way for patients infected with HCV to prevent insulin resistance.4 Bart J. Veldt*, Harry L. A. Janssen*, * Erasmus MC, Department of Gastroenterology and Hepatology, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Unclassified Mycobacteria Isolated from Human Suspect Tuberculosis Cases in Newfoundland: Preliminary Studies on 15 Strains
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Report of the Librarian
Authors: Henry R. Viets
Journal: New England Journal of Medicine (1947)

IT IS again the privilege of the Librarian to present to the Corporation of the Boston Medical Library his annual report — in this instance, his ninth accounting of the state of the Library. You, as fellows of the Library and owners of the building and its contents, will wish to know whether adequate service has been rendered to our readers, how well the collection has been maintained and what plans are contemplated to carry forward the fundamental aims of the Library in the next few years. The goal in general is the ever-elusive one of complete usefulness to its . . .