Cytological Diagnosis
Authors: MICHAEL J. BRENNAN
Journal: Annals of Internal Medicine (1965)

Editorials1 December 1965Cytological DiagnosisMICHAEL J. BRENNAN, M.D., F.A.C.P.MICHAEL J. BRENNAN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-6-1155 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDiagnosis of disease through the detailed morphological examination of cell suspensions spread on glass has been practiced by internists for 80 years. Recognition of the unique morphological character of the megaloblast of pernicious anemia by Ehrlich, Pappenheim, and Naegeli in the 1880's instituted the era of clinical diagnosis based upon specific cytostructural features of individual cells. Arinkin's demonstration of the feasibility of sternal marrow aspiration in 1927 led to further applications of cytostructural diagnosis in clinical medicine, particularly in the leukemias, the lymphomata, and multiple myeloma, as well as in Gaucher's and in Niemann-Pick's disease. Still later, lupus erythematosus disseminata...References1. REBUCKCROWLEY JWJH: A method of studying leukocytic functions in vivo. Ann. N. Y. Acad. Sci. 59: 757, 1955. CrossrefMedlineGoogle Scholar2. PRIESTREBUCKHAVEY RJJWGT: A new qualitative defect of leukocytic function in ulcerative colitis. Gastroenterology 38: 718, 1960. CrossrefGoogle Scholar3. CARLISLEGOOD JWRA: The inflammatory cycle, a method of study in Hurler's disease. Amer. J. Dis. Child. 99: 193, 1960. CrossrefGoogle Scholar4. SHIEIHAMBUCKBARNESS HGGWLA: A newly recognized forme fruste of Hurler's disease (gargoylism). Amer. J. Ophthal. 53: 753, 1962. MedlineGoogle Scholar5. KOSSDURFEE LGGR: Diagnostic Cytology. J. B. Lippincott Co., Philadelphia, 1961, 380 pages. Google Scholar6. FRANKSCOTT INWW: Cytodiagnosis of prostatic carcinoma: follow-up study. J. Urol. 79: 983, 1958. CrossrefMedlineGoogle Scholar7. WOOLNERMCDONALD LBJR: Diagnosis of carcinoma of lung: value of cytologic study of sputum and bronchial secretions. JAMA 139: 497, 1949. CrossrefMedlineGoogle Scholar8. MILLERHAARN EMEV: A comparison of the vaginal aspiration and cervical scraping techniques in the screening process for uterine cancer. Acta Cytol. 5: 214, 1961. MedlineGoogle Scholar9. ANDERSONGUNN WASA: The efficacy of a single cytology smear in the detection of cancer of the cervix. CA (New York) 13: 92, 1963. Google Scholar10. McCaughey RS Personal communication: , Medical Director, Cancer Detection Center, 4811 John R, Detroit, Michigan. Google Scholar11. FERGUSON JH: Positive cancer smears in teen-age girls. JAMA 178: 365, 1961. CrossrefMedlineGoogle Scholar12. REAGANHICKS JWDJ: Study of in situ and squamous cell cancer of uterine cervix. Cancer 6: 1200, 1953. CrossrefMedlineGoogle Scholar13. STERN E: Rate, stage, and patient age in cervical cancer: analysis of age-specific discovery rates for atypical hyperplasia, in situ cancer and invasive cancer in well population. Cancer 12: 933, 1959. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1965Volume 63, Issue 6Page: 1155-1159KeywordsBone marrowLeukemiaLupus erythematosusMultiple myelomaPernicious anemia ePublished: 1 December 2008 Issue Published: 1 December 1965 PDF downloadLoading ...