tbuckley/cabot-search huggingface dataset:
Abstract 1360: MMP-degraded vimentin is elevated in serum from patients with non-small cell lung cancer - development and biological validation of a new serum biomarker
Authors: Neel I. Nissen, Morten Karsdal, Nicholas Willumsen
Journal: Cancer Research (2019)

Abstract Background: Non-small cell lung cancer (NSCLS) accounts for 85% of lung cancers. The five-year survival rate decreases from 47% in stage I to 1% in stage IV, emphasizing the need for early detection. In lung cancer, the intermediate filament protein vimentin has been shown to be applicable for clinical pathology and associate with epithelial-to-mesenchymal transition. Vimentin has been found extracellularly and may be a target for proteolytic cleavage by matrix metalloproteases (MMPs). In fact, a MMP-degraded and citrullinated vimentin fragment (VICM) has shown biomarker potential in serum from patients with NSCLC. The aim of this study was to determine whether (un-citrullinated) MMP-degraded vimentin (VIM) can serve as a biomarker in patients with NSCLC. Methods: A monoclonal antibody was raised against a MMP-generated vimentin fragment identified by mass spectrometry. A competitive enzyme-linked immunosorbent assay (ELISA) was developed and technically validated. Levels of VIM were measured in serum from patients with NSCLC (n=40) and healthy controls (n=20) and compared to the equivalent citrullinated vimentin fragment (VICM). Results: The VIM ELISA assay was highly specific to MMP-degraded vimentin and with no cross-reactivity to VICM and the full-length vimentin. VIM was significantly elevated in serum from patients with NSCLC (p=0.0003) compared to controls whereas VICM was not (p=0.0741). In support, the diagnostic accuracy (AUROC) for VIM was 87.1% (p=&amp;lt;0.0001) vs 64% (p=0.0685) for VICM. Conclusion: The newly developed VIM assay detected significantly elevated levels of MMP-degraded vimentin in serum from patients with NSCLC compared to controls. Furthermore, this non-citrullinated vimentin fragment (VIM) shows stronger accuracy in separating NSCLC patients from healthy controls than the citrullinated equivalent (VICM), suggesting its biomarker potential and biological relevance in NSCLC. Future studies are needed to validate and expand on these findings. Citation Format: Neel I. Nissen, Morten Karsdal, Nicholas Willumsen. MMP-degraded vimentin is elevated in serum from patients with non-small cell lung cancer - development and biological validation of a new serum biomarker [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1360.
Social and Economic Factors in Patients With Coronary Disease
Authors: Philip L. P. Morris
Journal: JAMA (1992)

<h3>To the Editor.</h3> —The JOURNALrecently published two articles and an Editorial on the influence of social and economic factors on mortality following coronary artery disease.<sup>1-3</sup>Psychosocial effects on mortality following vascular disease affecting another end organ, the brain, have been studied by our group in recent years. Our findings are of relevance to the observations published inTHE JOURNAL. In an initial study of 88 Australian stroke patients followed up for 15 months, we found that depressed patients had a sevenfold higher risk of death than nondepressed patients (odds ratio, 7.9; 95% confidence interval, 1.2 to 53.2).<sup>4</sup>In a second series of 91 patients in Baltimore, Md, followed up for 10 years, we found that initially depressed patients had nearly three-and-a-half times the risk of death than nondepressed patients (odds ratio, 3.4; 95% confidence interval, 1.4 to 8.2). This finding held true even when other risk
Special Article
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tuberculous Meningitis
Authors: Peter R. Donald, Johan F. Schoeman
Journal: New England Journal of Medicine (2004)

As is vividly illustrated by the report by Thwaites et al. in this issue of the Journal (pages 1741–1751), tuberculous meningitis continues to exact a devastating toll in developed and developing countries, despite the availability of effective chemotherapy. In sub-Saharan Africa, because of the effects of human immunodeficiency virus and AIDS, tuberculosis is now the most common form of bacterial meningitis. In countries with a high incidence of tuberculosis, tuberculous meningitis is typically a disease of young children that develops three to six months after primary infection. In countries with a low incidence of tuberculosis, tuberculous meningitis more commonly affects . . .
Tc-99m MDP Bone Scintigraphy in a Patient with Multicentric Osteosarcoma
Authors: FIKRET T. ÇERMIK, AHMET SALAN, FATIH M. FIRAT, AKIÿR S BERKARDA
Journal: Clinical Nuclear Medicine (2003)

A case of multicentric osteosarcoma (MOS) is presented. A 14-year-old boy had a 2-month history of pain and swelling in his right leg. After radiologic evaluation of the right knee, bone scintigraphy showed increased uptake in the primary tumor and 11 metastatic sites. Histopathologic analysis revealed osteosarcoma of the primary lesion.
Stress Hematopoiesis Reveals Abnormal Control of Self-Renewal, Lineage-Bias and Myeloid Differentiation in Mll Partial Tandem Duplication (Mll-PTD) Hematopoietic Stem/Progenitor Cells
Authors: Yue Zhang, Xiaomei Yan, Goro Sashida, Xinghui Zhao, Yalan Rao, Susumu Goyama, Susan Whitman, Nicholas Zorko, Kelsie M. Bernot, Rajeana M. Conway, David Witte, Qianfei Wang, Daniel G Tenen, Zhijian Xiao, Guido Marcucci, James C. Mulloy, H. Leighton Grimes, Michael A. Caligiuri, Gang Huang
Journal: Blood (2012)
Possible vasopressin role in premenstrual syndrome?
Authors: P. Gunby
Journal: JAMA (1984)

Premenstrual syndrome has been called an ancient woe that may be the newest women's health issue in the United States (<i>JAMA</i>[MEDICAL NEWS] 1981;245:1393-1396). Now, in the latest study of at least one possible aspect of the problem, University of Chicago Medical Center investigators are pondering a possible role for the antidiuretic pituitary hormone vasopressin. Usually applied to severe cases, the term premenstrual syndrome can include headache, edema, appetite alterations including craving for sweet or salty foods, spontaneous crying, anxiety, depression, skin eruptions resembling acne, fatigue, abdominal distention, constipation, and breast swelling with mastalgia (<i>JAMA</i>[MEDICAL NEWS] 1983;249:2864-2866 and 250:1371-1375). The hypothesis being pursued by Gary Shangold, MD, assistant professor in the University of Chicago's Department of Obstetrics and Gynecology, is that—because regulation of the hormone's secretion throughout the menstrual cycle is not completely understood—"it makes sense that vasopressin would have a role in symptoms relating to water balance like
PORTUGAL
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Rheumatoid Arthritis and Amyloid Disease
Authors: B. Lush, E. Fletcher, J. F. Buchan
Journal: Annals of the Rheumatic Diseases (1949)

reports a follow-up study of the case therein described.Progress of the Patient-since the Report in December 1948 Just over three hundred days after the onset of the patient's illness and while she was still in the Royal Free Hospital she suddenly developed a rigor just after getting into bed.There were no premonitory symptoms or us.Her temperature rapidly rose to 104 60 F. and tde pulse to 130 per minute.Her only complaints were ofpain over the sacrum and in the region of the left knee.Apart from the fever, tachycardia, and collapsed con- dition, no new physical signs were elicited.The blood pressure was 100/50 mm.Hg.The blood picture'was unusual (white cells 9,000 per c.mm. of blood; poly- morphs 93 per cent., lymphocytes 7 per cent.), but no explanation for it could be found, and at the next exami- nation it was more normal (white cells 7,700 per c:mm.; polymorphs 38 per cent., lymphocytes 41 per cent., monocytes 13 per cent., eosinophils 5 per cent., basophils 3 per cent.).The urine contained a trace of protein and a few pus cells, but was sterile on culture.No satisfactory explanation of the cause of this febrile attack was forthcoming.Infection was considered to be a possibility, and in view of her desperate condition it was considered justifiable to give the patient a course of penicillin, although this might obscure the diagnosis'; 250,000 units were given twice daily without demonstrable effect.For four days she remained shocked and ran a hectic fever; then her condition slowly and spon- taneously subsided.Two weeks after the onset of the
CSIG-32. DUAL PI3K/Akt INHIBITION TO OVERCOME THE P-gp/BCRP DRUG EFFLUX SYSTEM FOR IMPROVED DRUG DELIVERY IN GLIOBLASTOMA THERAPY
Authors: Anika Hartz, Julia Schulz, Brent Sokola, Bjoern Bauer
Journal: Neuro-Oncology (2018)

The blood-brain barrier is a primary obstacle for effective anticancer drug therapy of patients with glioblastoma multiforme (GBM). On a molecular level, failure of anticancer drug treatment is largely due to the blood-brain barrier efflux transporters P-glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP). P-gp and BCRP (P-gp/BCRP) work together to restrict anticancer drugs from crossing the barrier and from entering the brain to reach tumor targets. We found that PI3K/Akt regulates P-gp/BCRP in brain capillaries of the rodent and human blood-brain barrier. Our in vivo data show that combination treatment with LY294002 (PI3K inhibitor) and triciribine (Akt inhibitor) downregulates P-gp and BCRP protein expression and transport activity in brain capillaries. We also have evidence from brain capillaries isolated from GBM mice and GBM patients showing that GBM induces P-gp/BCRP overexpression in capillaries in the brain hemisphere that is contralateral to the primary tumor. These findings indicate that P-gp/BCRP overexpression in brain capillaries protects invasive tumor cells that are scattered throughout the brain from being targeted by anticancer drugs. To overcome this obstacle, we are currently developing a novel therapeutic strategy by targeting PI3K/Akt to transiently decrease P-gp/BCRP expression and activity, thus, creating a “window-in-time” during which anticancer drugs can enter the brain.
Vitamin C may enhance healing of caustic corneal burns
Authors: P. Gunby
Journal: JAMA (1980)

Patients A. atients are being recruited for a three-year, 12-center, National Eye Institute-supported clinical trial of vitamin C in treating severe, caustic eye burns. Volunteers will be randomized into groups treated either with ascorbic acid or with a placebo, according to Roswell R. Pfister, MD, University of Alabama School of Medicine, Birmingham. Pfister, professor and chairman of the Department of Ophthalmology, told a Research to Prevent Blindness seminar in Los Angeles, however, that "it must be understood that the severity of this kind of burn precludes any chance of the cornea's becoming clear, no matter what the treatment." Such burns result most often from industrial and farming mishaps, accidents in the home, hobby activities or, unfortunately, "as a means of social—often family—retribution," said Pfister. "The majority are mild or moderate, healing slowly but without complications. Only a small proportion are severe, but management of these is incredibly difficult; ulceration and
Influenza B Virus Outbreak on a Cruise Ship--Northern Europe, 2000
Journal: JAMA (2001)

During June 23-July 5, 2000, an outbreak of respiratory illnesses occurred on the MS Rotterdam (Holland America Line & Windstar Cruises) during a 12-day Baltic cruise from the United Kingdom to Germany via Russia. The ship carried 1311 passengers, primarily from the United States, and 506 crew members from many countries. Although results of rapid viral testing for influenza A and B viruses were negative, immunofluorescence staining and viral culture results implicated influenza B virus infection as the cause of the outbreak. This report summarizes the findings of the outbreak investigation conducted by the ship's medical department and describes the measures taken to control the outbreak. Travelers at high risk for complications of influenza who were not vaccinated with influenza vaccine during the preceding fall or winter should consider receiving influenza vaccine before travel with large tourist groups at any time of year or to certain regions of the world.
Delayed trial of HIV immune globulin to protect infants of infected mothers is likely to resume
Authors: P. Cotton
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Depression of poison ivy skin tests by measles vaccine
Authors: R. Blumhardt
Journal: JAMA (1968)

The degree of sensitivity to varying dilutions of a poison ivy antigen was established by patch tests in seven individuals. Administration of the live, attenuated measles virus vaccine (Schwarz) to this small group of subjects resulted in a temporary reduction of sensitivity, most marked (33% of control values) between the third and sixth weeks postimmunization. At nine weeks, the sensitivity was returning to preimmunization levels. Five control subjects showed no change in their degree of sensitivity.
Book Review The Medical Department of the United States Army In The World War. Volume XII. Pathology Of The Acute Respiratory Diseases, and of Gas Gangrene Following War Wounds . Prepared under The Direction of Maj. Gen. M. W. Ireland, The Surgeon General. By Maj. George R. Callender, M.C., and Maj. James F. Coupal. Washington: U. S. Government Printing Office: 1929.
Journal: New England Journal of Medicine (1929)
Addendum
Journal: American Journal of Hematology (1985)

relapse.The mechanism by which the ATG induced the remissions is not known.The rapid development of reticulocytosis after initiation of the ATG therapy is not typical of that seen in RCA patients responding to glucocorticoids or alkylator drug treatment [ 1-51 and suggests that the ATG-induced remissions might be mediated by alterations of cell-mediated (as opposed to antibody-mediated) processes.ATG should be considered for the treatment of patients with RCA who fail to respond to glucocorticoid/ alkylator drug treatment.
Correction
Journal: BMJ (1952)

ANY QUESTIONS ?EDITISJRNAL 'and treatment; it is only if dancing is performed excessively and injudiciously that structural changes in the feet are to 'be feared.This is unlikely to happen in properly con- ducted classes such as are included in the school curriculum.Tap dancing similarly is beneficial, possibly more so than -ballet dancing, because no abnormal stress is placed upon the anterior part of the foot.The rapid rhythmical move- ments of a tap dance encourage the proper development and ,co-ordination of the intrinsic and extrinsic muscles.Serum Acid Phosphatase Levels Q.-(a) Why is the serum acid phosphatase level raised .incarcinoma of the prostate ? (b) Must there be bone secondaries before it is elevated ?A.-(a) There is no satisfactory explanation for the raised 'serum acid phosphatase level in carcinoma of the prostate.
Update: Influenza Activity — Worldwide
Journal: JAMA (1989)

From October 1994 through August 1995, influenza activity occurred at low to moderate levels in most parts of the world. Influenza activity usually was associated with the cocirculation of influenza types A and B viruses. Overall, influenza A(H3N2) was the predominant influenza A subtype, but isolation of influenza A(H1N1) viruses increased during this period and was the most frequently isolated influenza virus in Australia from March through August. This report summarizes influenza activity worldwide from March through August 1995.
Tenth Annual Congress of the European Society for Medical Oncology
Journal: JNCI Journal of the National Cancer Institute (1984)

Tenth Annual Congress of the European Society for Medical Oncology Get access JNCI: Journal of the National Cancer Institute, Volume 72, Issue 5, May 1984, Page 1210, https://doi.org/10.1093/jnci/72.5.1210-b Published: 01 May 1984
Hormonal Requirements of Endometriosis Yield Clues to Treatment
Journal: JAMA (1981)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bagatelle
Authors: Clayton J. Baker
Journal: Annals of Internal Medicine (2006)

Ad Libitum20 June 2006BagatelleClayton J. Baker, MDClayton J. Baker, MDFrom Pittsford, NY 14534.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-144-12-200606200-00007 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail No poet deserves praisefor remaining a poet.Trifles stay trifleshowever beautiful.Floor sweepers, florists, fluoroscopistswin little acclaimgod knows, though god knowsa good versewhen (s)he hears one—recalls her sun's gold reflectionin sparkling hardwood,two dozen bloody bursting longstems orthe interlaced branching radiance ofthis biliary tree silhouetted infull intraoperativebloom.Clayton J. Baker, MDPittsford, NY 14534 Author, Article, and Disclosure InformationAffiliations: From Pittsford, NY 14534.Current Author Address: Clayton J. Baker, MD, 1919 Calkins Road, Pittsford, NY 14534. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 20 June 2006Volume 144, Issue 12Page: 903KeywordsBiliary system ePublished: 20 June 2006 Issue Published: 20 June 2006 Copyright & PermissionsCopyright © 2006 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Cellular location of proteins related to iron absorption and transport
Authors: Marcia J. Simovich, Marcel E. Conrad, Jay N. Umbreit, Elizabeth G. Moore, Lucille N. Hainsworth, Hilary K. Smith
Journal: American Journal of Hematology (2002)

K562 erythroleukemia cells and IEC6 rat cells were examined using confocal microscopy and antibodies raised against DMT-1 (Nramp-2, DCT-1), transferrin receptor (CD71), β3 integrin (CD61), mobilferrin (calreticulin), and Hephaestin. The cellular location of each of these proteins was identified by immunofluorescence in both saponin-permeabilized and non-permeabilized cells. Fluorescent reactivity was observed on or near the cell surface of each of these proteins, suggesting that they might participate in surface membrane transport of iron. Fluorescence was observed in the region of the cytoplasm with each antibody to include β3 integrin and transferrin receptor. It was pronounced in cells incubated with mobilferrin, Hephaestin, and DMT-1 antibodies. Speckled nuclear fluorescence was observed in cells incubated with anti-DMT-1. While these observations are descriptive, they demonstrate that there are significant concentrations of DMT-1, mobilferrin, and Hephaestin in the cytoplasmic region of cells. This suggests that there may be intracellular roles for these proteins in addition to their serving to transit iron across the cell surface membrane. Am. J. Hematol. 69:164–170, 2002. © 2002 Wiley-Liss, Inc.
Effects of statin on nitric oxide bioactivity and matrix metalloproteinases-9 in hypercholesterolemic patients with coronary artery disease who remained hypercholesterolemic on step II diet Kwang K. Koh, Ji W. Son, Dong K. Jin, Jeong Y. Ahn, Gi S. Park, In S. Choi, Min S. Sohn, Tae H. Ahn, Eak K. Shin. Cardiology, Inchon, South Korea, Clinical Pathology, Inchon, South Korea
Journal: Journal of the American College of Cardiology (2001)