tbuckley/cabot-search huggingface dataset:
Customer Disservice?
Authors: James L. Glazer
Journal: Annals of Internal Medicine (2006)

On Being a Doctor3 January 2006Customer Disservice?James L. Glazer, MDJames L. Glazer, MDFrom the Maine Medical Center, Portland, Maine 04101.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-144-1-200601030-00012 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Humming a little tune as I rounded the corner and headed down the homestretch of my afternoon in the office, I plucked a chart from the wall outside of room 14. Carol Todd, a woman of 48, had come to see me about “cellulitis of the scalp.” My nurse had scrawled a question mark after her history, and then an exclamation point. I shot a quizzical look into the nurses' pod at her. She rolled her eyes at me and mouthed the words, “You'll see.” I knocked on the door and entered the examination room.Mrs. Todd, a short, stout ... Author, Article, and Disclosure InformationAffiliations: From the Maine Medical Center, Portland, Maine 04101.Corresponding Author: James L. Glazer, MD, Maine Medical Center, 272 Congress Street, Portland, ME 04101; e-mail, [email protected]org. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoCommentary: Customer Disservice? Troyen A. Brennan Metrics 3 January 2006Volume 144, Issue 1Page: 61-62KeywordsAntibioticsCellulitisChartsEmergency departmentEmotionsNursesPharyngitisResidencyTicksUpper respiratory tract infections ePublished: 3 January 2006 Issue Published: 3 January 2006 Copyright & PermissionsCopyright © 2006 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Clinical Ethics
Authors: Robert L. Fine
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Intercellular immune adhesion molecules in human liver transplants: Overview on expression patterns of leukocyte receptor and ligand molecules
Authors: G Steinhoff
Journal: Hepatology (1993)

Recently it has become clear that the inflammatory response of immune cells to target cells and extracellular matrix is regulated by several receptor-ligand molecules. Three main classes of molecules mediating intercellular adhesion and activation processes have been identified: the integrin, immunoglobulin and selectin families. This study surveys the expression of adhesion molecules on resident and infiltrating cells in human liver grafts. The patterns of cellular expression and inducibility in different pathological conditions of the graft are described. Our results show organ-specific regulation of the different adhesion molecules during alloreactive reactions and other types of inflammatory reactions. No rejection-specific patterns were detected on comparison with reperfusion damage or infectious transplant inflammation. Major differences were noted in the composition of the portal tract and sinusoid with regard to endothelial and parenchymal cell expression of cell-cell and cell-matrix adhesion molecules. Intravascular and interstitial differences in the expression patterns of leukocyte adhesion receptors support a concept of stepwise expression. The implications for the appearance of inflammatory reactions in human liver in immunosuppressive and therapeutic interventions are discussed. (HEPATOLOGY 1993;18:440–453).
Poliomyelitis Prevention: Enhanced-Potency Inactivated Poliomyelitis Vaccine—Supplementary Statement
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 1182: New bioluminescent strategies to measure kinetics of immune cell-mediated cytotoxicity
Authors: Maggie L. Bach, Natasha Karassina, Peter Hofsteen, Donna Leippe, James Cali, Jolanta Vidugiriene
Journal: Cancer Research (2019)

Abstract The number of immunotherapeutic strategies for treating cancer have expanded in recent years, increasing the need for assays that can be used to assess their effectiveness. To facilitate studies of these immunotherapies, we developed bioluminescent methods that could rapidly and sensitively measure target cell cytotoxicity. Two approaches were developed. The first method utilizes a bioluminescent enzymatic activity assay for a well-accepted cytotoxicity marker, lactate dehydrogenase (LDH), which is rapidly released from dead cells. With the improved sensitivity of the bioluminescent assay, lower levels of LDH can be measured, resulting in the detection of fewer dead cells (LOD&amp;lt; 10 cells). Cytotoxicity in both 2D and 3D cell cultures can be monitored over time by removing samples of medium at different time points. Here we present examples in which this assay was used to test the effectiveness of immunotherapeutic treatments including antibody-drug conjugates (ADC) and antibody-dependent cell-mediated cytotoxicity (ADCC). In ADCC models, cell killing was detectable at early time points (by 2 hours). Increases in the cytotoxicity of individual samples could be followed over time, from early time points to 24 hours. In the second approach we developed a novel bioluminescent assay based on the specific labeling of target cells. With this method, intracellular proteins in live target cells are covalently labeled. Upon target cell death, the labeled proteins are released from the cell and the label is quantitated using bioluminescence detection reagents. Using this assay, we were able to quantitate the killing of target cells in both ADCC and CAR-T applications. By adding the detection reagents directly to the medium at the start of the ADCC reaction, cell death was monitored in real-time for up to 6 hours. Neither assay requires genetic engineering and both involve no or minimal target cell preparation. They are applicable to multiple cell types and the non-lytic nature of these approaches provides kinetic capabilities and opportunities for multiplexing. The ability to rapidly quantitate cytotoxicity will facilitate the functional analysis of immunotherapies. Citation Format: Maggie L. Bach, Natasha Karassina, Peter Hofsteen, Donna Leippe, James Cali, Jolanta Vidugiriene. New bioluminescent strategies to measure kinetics of immune cell-mediated cytotoxicity [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1182.
Endoplasmic Reticulum Stress in Disease Pathogenesis
Authors: Jonathan H. Lin, Peter Walter, T.S. Benedict Yen
Journal: Annual Review of Pathology Mechanisms of Disease (2007)

The endoplasmic reticulum (ER) is the site of synthesis and folding of membrane and secretory proteins, which, collectively, represent a large fraction of the total protein output of a mammalian cell.Therefore, the protein flux through the ER must be carefully monitored for abnormalities, including the buildup of misfolded proteins.Mammalian cells have evolved an intricate set of signaling pathways from the ER to the cytosol and nucleus, to allow the cell to respond to the presence of misfolded proteins within the ER.These pathways, known collectively as the unfolded protein response, are important for normal cellular homeostasis and organismal development and may also play key roles in the pathogenesis of many diseases.This review provides background information on the unfolded protein response and discusses a selection of diseases whose pathogenesis involves ER stress.
Dr. Formad's Article.
Journal: JAMA (1884)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AUGUST VON WASSERMANN (1866-1925) WASSERMANN REACTION
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
NURSING
Authors: A. Gieseking, P. Williams, U. Piamjariyakul, K. Kelly, C. Dobos, R. Connor, A. Williams, K. Sheehan, B. Devorin, C. Hoeppner, M. Lucas, L. Barakat, W. Hobbie, J. Deatrick, K. Black, W. Beaudoin, C. McDonald, R. Tulloh, L. Montero, C. Frias, A. Canete, M. Pablo, C. Rebeca, H. Miguel, S. Patricia, C. Victoria, S. Avula, L. Abernethy, B. Pizer, B. Pettorini, D. Williams, C. Mallucci, D. Lafond, H. DeLuca, K. Steacy, P. Cullen, I. Moore, L. Yeh-Nayre, N. Le Floch, M. Levy, D. Donoghue, J. Crawford, C. Hoeppner, P. Paiva, A. Cappellano, C. Dias, N. Silva, E. Clark, M. Hemenway, J. Madden, N. Foreman, L. Dorneman, J. Rossiter, T. Arvanitis, K. Natarajan, M. Wilson, N. Davies, S. Gill, R. Grazier, J. Crouch, D. Auer, C. Clark, R. Grundy, D. Hargrave, F. Howe, T. Jaspan, M. Leach, L. MacPherson, G. Payne, D. Saunders, A. Peet, J. R. Madden, H. Bess, C. Chordas, D. LaFond, R. Packer, J. Hilden, A. Smith, S. Chi, K. Marcus, N. K. Foreman, A. K. Liu, H. Bess, D. Stillwell, G. Olavarria, D. Thomas, A. Smith
Journal: Neuro-Oncology (2012)
Development of residency training in preventive medicine
Authors: J. C. Hume
Journal: JAMA (1966)

The existing pattern for training physicians for specialty practice following medical school and internship is a relatively modern development. While many hospitals had resident medical officers during the 19th century, apparently the first residency system in its modern sense was established by Halsted at the Johns Hopkins Hospital in 1890.<sup>1</sup>The first listing of residencies inThe Journaldid not appear until 1927. At that time there were 1,776 positions offered. Table 1 shows the growth of such programs in relation to the numbers of medical schools, medical graduates, internships offered, and residencies offered for selected years. These figures emphasize the modernity of residency programs and demonstrate certain landmarks and trends in the education of physicians. The major points of interest are perhaps the following: The sharp decline in the number of medical schools and graduates between 1905 and 1920—reflecting the revolution in medical education resulting in the
Sudden, Unexpected Nocturnal Deaths in Washington
Authors: Ron Munger
Journal: JAMA (1985)

<h3>To the Editor.—</h3> Since July 1977, at least 80 sudden, unexplained nocturnal deaths (SUND) have been reported nationwide among young, previously healthy Southeast Asian male refugees in the United States. A series of the cases was recently described,<sup>1</sup>but the etiology of the problem remains unknown. We are writing to report an unusual presentation of this phenomenon, the sixth such case reported to date in the state of Washington. <h3>Report of a Case.—</h3> The victim was a previously healthy 30-year-old Laotian man who had emigrated to this country four years previously. Around 3 AM his wife noted that he was unresponsive and had tonic, clonic contractions in all four extremities. The contractions ceased after a few minutes, and the family was able to arouse him by shaking him and pouring water on his head. He woke up enough to carry on a conversation. When paramedics, who had been called
Hyaluronic acid uptake by the isolated, perfused rat liver: An index of hepatic sinusoidal endothelial cell function
Authors: I Deaciuc
Journal: Hepatology (1993)

Previous studies indicate that sinusoidal endothelial cells bind and internalize hyaluronic acid at much greater rates than do other liver cells. Thus hepatic hyaluronic acid removal rate may be indicative of sinusoidal endothelial cell function. In these studies the uptake of hyaluronic acid (molecular weight 1.3 × 106) was measured in isolated perfused rat liver under a variety of conditions. Uptake was dependent on hyaluronic acid concentration. At all concentrations tested, the rate of hyaluronic acid uptake stabilized at a steady-state level 2 to 3 min after development of a high rate of apparent uptake. At saturating hyaluronic acid concentration (150 ng · ml−1), the steady-state uptake rate was 10.4 ± 1.0 μg · gm−1 liver wet wt · hr−1 which is as high as or higher than the rates reported for isolated rat liver sinusoidal endothelial cells. The half-maximal rate of uptake was attained at a hyaluronic acid concentration of 80 ng · ml−1. Hyaluronic acid uptake was inhibited by heparin (80%), a competitive ligand for the hyaluronic acid receptor on sinusoidal endothelial cells; 4β-phorbol 12β-O-myristoyl 13α-acetate (25% to 50%), a tumor promoter and activator of protein kinase C; prostaglandin F2α (24% to 52%), an eicosanoid secreted in the liver by Kupffer cells; A23187 (33% to 66%), a Ca2+ ionophore; and Escherichia coli lipopolysaccharide (16% to 43%). Platelet activating factor did not affect hyaluronic acid uptake by the perfused liver. Hyaluronic acid uptake was increased by 50% after a 24-hr fast. Because previous studies indicate that the hepatic sinusoidal endothelial cells are almost exclusively responsible for the hepatic clearance of circulating hyaluronic acid, this study suggests that measurement of hyaluronic acid uptake by the perfused liver may allow assessment of sinusoidal endothelial cell function under the conditions in which the in vivo architecture of the liver remains intact. (HEPATOLOGY 1993;17:266–272.)
General Urology
Authors: Richard G. Middleton
Journal: JAMA (1970)

The sixth edition of<i>General Urology</i>contains two new chapters, embryology of the genitourinary system by Tanagho, and radioisotopic kidney studies by Powell and Weiss. Otherwise this edition is similar to the fifth edition, published in 1966. Dr. Smith, as in previous editions of the book, does not attempt to cover the various aspects of urology in detail or acknowledge differing approaches and points of view. Rather, he presents a brief, sound, well-organized system of urology based upon his own ideas, experience, and interpretation of the urologic literature. The author's personality is evident, and in places his opinions are mixed too freely with what most of us would regard as fact. Nearly every urologist would differ with the author on minor matters here and there, but few would have major exceptions. The book is intended primarily for the medical student and the physician who is not a specialist in urology.
The dynamics of FIB4 after sustained viral response predicts the risk of liver-related complication in HCV cirrhosis (ANRS CO12 Cirvir)
Authors: Jerome Boursier, Pierre Nahon, Maxime Guettier, Clémence Moreau, Jérémie Riou, Etienne Audureau, Marine Roux
Journal: Journal of Hepatology (2020)
Follow-up after abortion.
Authors: A. Gillis
Journal: BMJ (1969)

tunity class for handicapped children which attempts to remedy this shortage here in Stevenage.The class is founded upon three aims; to provide nursery facilities for handicapped children; to enable handicapped children to mix with normal children; and to enable mothers to meet at the same time, yet apart from their children.Children with any form or degree of handicap are welcome.
P1.01-96 Concurrent ALK/EGFR Alterations in Chinese Lung Cancers: Frequency, Clinical Features, and Differential Response to Therapy
Authors: D. Wu, J. Liu, Z. Mu, L. Liu, K. Li, R. Jiang, P. Chen, Q. Zhou, M. Jin, Y. Ma, Y. Xie, J. Xiang, T. Zhang, B. Li, B. Yu
Journal: Journal of Thoracic Oncology (2018)
Mechanical Efficiency of the Heart After Arrest with Deep Hypothermia
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The inositol phosphate-calcium signaling system in nonexcitable cells
Authors: J. W. Putney
Journal: Endocrine Reviews (1993)

IN 1983, Michael Berridge proposed (1), and subsequently with collaborators demonstrated (2), that d-myo-inositol 1,4,5-trisphosphate [(1,4,5)IP3], generated in the course of receptor-activated inositol lipid turnover, was a second messenger signaling the release of stored calcium from intracellular sites to the cytoplasm of activated cells. The significance of this discovery was enormous. The explosion of interest and research in this area in the last decade has demonstrated that the inositol phosphate-calcium signaling system plays a critical role in the mechanisms by which hormones regulate diverse processes such as muscle contraction, cell secretion, metabolism, and cell growth and differentiation. Despite the consensus regarding the central role of (1,4,5)IP3 in intracellular Ca2+ mobilization, the extremely complex nature of Ca2+ signaling and inositol phosphate metabolism has spawned controversies. What is the meaning of the enigmatically complex pathways of inositol phosphate metabolism? Clearly (1,4,5)IP3 is the signal for intracellular Ca2+ release, but how is calcium entry across the plasma membrane regulated? What are the mechanism(s) and physiological significance of calcium oscillations? This review will attempt first to summarize the less controversial aspects of the inositol phosphate-calcium signaling system and then to address some of the more difficult issues. We will not pretend to offer definitive solutions to these quandaries, but we will attempt to identify the major issues of controversy. In some cases, we will speculate on potential directions for their resolution. For the most part, as the title of this review implies, the examples and mechanisms discussed will be drawn from published studies on nonexcitable cells, because these cells appear to express the most fundamental and ubiquitous mechanisms of Ca2+ regulation through the inositol phosphate system. In terms of calcium signaling, we are using the term nonexcitable to indicate absence of voltagegated calcium channels. The reader is also directed to a number of recent publications that address, from a somewhat different perspective, some of the specific topics covered in this review (3–15).