tbuckley/cabot-search huggingface dataset:
Brain tumors in man and animals: report of a workshop
Journal: Environmental Health Perspectives (1986)

This report summarizes the results of a workshop on brain tumors in man and animals.Animals, especially rodents are often used as surrogates for man to detect chemicals that have the potential to induce brain tumors in man.Therefore, the workshop was focused mainly on brain tumors in the F344 rat and B6C3F1 mouse because of the frequent use of these strains in long-term carcinogenesis studies.Over 100 brain tumors in F344 rats and more than 50 brain tumors in B6C3F1 mice were reviewed and compared to tumors found in man and domestic or companion animals.In the F344 rat, spontaneous brain tumors are uncommon, most are of glial origin, and the highly undifferentiated glioblastoma multiforme, a frequent tumor of man was not found.In the B6C3F1 mouse, brain tumors are exceedingly rare.Lipomas of the choroid plexus and meningiomas together account for more than 50% of the tumors found.Both rodent strains examined have low background rates and very little variability between control groups.
THE BEST METHOD OF TYING THE UMBILICAL CORD
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pericardial Disease
Authors: David H. Spodick
Journal: JAMA (1997)

<h3>To the Editor.</h3> —I am grateful to Dr Hancock for the warm and perceptive review of my new book.<sup>1</sup>At the risk of seeming churlish, I feel compelled to address the very few errors because they are of clinical (ie, factual) and conceptual importance. First, low voltage in the electrocardiogram in pericardial diseases is pluricausal and not universal. It is clearly stated in the text that in cardiac tamponade the degree of change is not related to the severity of hemodynamic compromise.<sup>1(p57)</sup>Second, myocardial ischemia does not occur during pericardial effusion and tamponade. Indeed, it is clearly stated that with normal coronary arteries "coronary blood flow is decreased but remains adequate to support aerobic metabolism because there is proportional reduction in cardiac work.... Even coronary vasodilator reserve, capacitance, and resistance are not significantly impaired."<sup>1(pp186,187)</sup>In constrictive pericarditis, discrete coronary obstruction has been repeatedly reported. Third, true pulsus
CHALONES AND CANCER
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Editorial Board
Authors: Jeffrey Bernhard, Thomas Cropley, Karen Wiss, Melissa Derby, Andrew Blauvelt, Ponciano Cruz, Texas Medicine, Jane Grant-Kels, Alexandra Kimball, Marta Petersen, Stuart Salasche, Martin Weinstock, Rhode Island, Michael Bigby, Jean Bolognia, New Haven, Luis Diaz, Chapel Hill, Carolina Lebwohl, New York, Donald Miech, Wisconsin Ginat, W Mirowski, Scott Norton, Maryland Olsen, North Carolina, Amy Paller, Nathaniel Jellinek, J Smith
Journal: Journal of the American Academy of Dermatology (2005)
Auricular chondritis in NOD.DQ8.A o (Ag7-/-) transgenic mice resembles human relapsing polychondritis
Authors: V. Taneja
Journal: Journal of Clinical Investigation (2003)

Relapsing polychondritis is a multisystem autoimmune disease involving cartilage destruction but no known causative antigen. HLA-DQ8 has been associated with various autoimmune diseases in humans. To study the role of DQ8 in autoimmune diseases, we have generated transgenic mice expressing DQ8 (DQA1*0301, DQB1*0302) in a NOD background lacking endogenous class II molecules (Aβo). Upon immunization with type II collagen (CII), 85% of NOD.DQ8 mice develop severe experimental polychondritis, auricular chondritis, and polyarthritis, with clinical and histological similarities to relapsing polychondritis (RP) in humans. CII-immunized mice mount a T cell response and produce Ab’s to type IX collagen (CIX) and self-CII. Transgene-negative littermates do not develop any serological and clinical manifestations following immunization. B10.DQ8 transgenic mice develop polyarthritis and Ab’s to CII only. The susceptibility to auricular chondritis in NOD.DQ8 mice can be attributed to response to CIX. A higher number of activated cells, CD4+CD44hiCD62Llo, and lower regulatory cells CD4+CD152+CD25+ were observed in NOD.DQ8 mice compared with B10.DQ8 mice. The NOD.DQ8 mice provide a model of RP with a high disease incidence and multiple organ involvement to investigate putative autoantigen and regulatory cells involved in disease pathogenesis. An experimental model restricted by the human class II molecule will be valuable when studying the role of various collagens in immunologic and pathologic responses in human RP.
Incorrect Word.—
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Focusing on ophthalmology
Authors: None The Lancet
Journal: The Lancet (2012)

Globally, 285 million people are visually impaired, with cataract, glaucoma, age-related macular degeneration, diabetic retinopathy, refractive errors, and corneal diseases accounting for most of this burden. Tien Wong and colleagues, in The Lancet ophthalmology Series, provide in-depth reviews of two of these leading causes of visual impairment—myopia and age-related macular degeneration. In a third paper they assess progress in corneal transplantation surgery.
Cardioprotective effect of vasopeptidase inhibitors in the infarcted and remodeling rat heart Nathalie Lapointe, Charles Blais Jr, Albert Adam, Martin Sirois, Robert Clement, Hugues Gosselin, Jean L Rouleau. Toronto General Hospital, Toronto, ON, Canada, University of Montreal, Montreal, PQ, Canada
Journal: Journal of the American College of Cardiology (2001)
A case of congestive cardiomyopathy. Demonstration at the Royal College of Physicians of London.
Journal: BMJ (1980)

MacArthur (2) presented the case.DR MAcARTHUR: The patient was born in March 1931 and worked as a storekeeper.He was well until September 1974, when he complained of backache, breathlessness, and flu-like symptoms.On examination his blood pressure was 140/80 mm Hg, he was afebrile, and his chest and abdomen were normal.His illness was slow to settle and a viral pneumonia was suspected.A chest radiograph (fig 1) was reported to be normal but, in retrospect, showed a slightly enlarged heart.The patient returned to work but continued to feel unwell for some months.He did not see his GP again until January 1976, when he gave a history of wheezing and coughing at night.The GP found his chest normal and his blood pressure 120/80 mm Hg.He was FIG 1-Chest radiograph taken on 14 October 1974 showing slightly enlarged heart.
Incorrect Institutional Affiliation
Authors: Ravi Salgia
Journal: JAMA Oncology (2016)

Paige Maas, PhD; Myrto Barrdahl, PhD; Amit D. Joshi, PhD; Paul L. Auer, PhD; Mia M. Gaudet, PhD; Roger L. Milne, PhD; Fredrick R. Schumacher, PhD; William F. Anderson, MD, MPH; David Check, BS; Subham Chattopadhyay, BS; Laura Baglietto, PhD; Christine D. Berg, PhD; Stephen J. Chanock, MD; David G. Cox, PhD; Jonine D. Figueroa, PhD; Mitchell H. Gail, MD, PhD; Barry I. Graubard, PhD; Christopher A. Haiman, ScD; Susan E. Hankinson, ScD; Robert N. Hoover, MD, ScD; Claudine Isaacs, MD; Laurence N. Kolonel, PhD; Loic Le Marchand, MD, PhD; I-Min Lee, ScD; Sara Lindström, PhD; Kim Overvad, PhD; Isabelle Romieu, MD, MPH, ScD; Maria-Jose Sanchez, PhD; Melissa C. Southey, PhD; Daniel O. Stram, PhD; Rosario Tumino, PhD; Tyler J. VanderWeele, PhD; Walter C. Willett, MD, DrPh; Shumin Zhang, PhD; Julie E. Buring, ScD; Federico Canzian, PhD; Susan M. Gapstur, PhD; Brian E. Henderson, MD; David J. Hunter, MBBS, ScD; Graham G Giles, PhD; Ross L. Prentice, PhD; Regina G. Ziegler, PhD, MPH; Peter Kraft, PhD; Montse Garcia-Closas, MPH, DrPH; Nilanjan Chatterjee, PhD
US Medical School Finances
Authors: Leanne D. John
Journal: JAMA (1991)

This 31st review of medical school finances reports current revenue and expenditure patterns for US medical schools and identifies trends in the financing of medical education in the United States. The interval covered by this series of reports can be seen as two distinct periods: the 21 years between academic years 1958-1959 and 1978-1979 and the 10 years between academic years 1979-1980 and 1989-1990, the latest full year for which data are available. The first period was characterized by large absolute and relative increases in all aspects of medical education (Table 1). The number of schools grew by almost 50%; the number of candidates for professional and academic doctorates doubled and tripled, respectively; the number of postdoctoral students mushroomed; and the number of full-time faculty almost quintupled. While these measures of medical school activity were increasing so substantially, medical school expenditures increased even faster, growing by a factor of 17.5
FRAUD IN MEDICAL EXAMINATIONS.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The predictive value of serum haptoglobin in hemolytic disease
Authors: A. Marchand
Journal: JAMA (1980)

Using a rapid, highly sensitive immunoprecipitin nephelometric technique, a retrospective study was undertaken to evaluate the clinical usefulness of determining serum haptoglobin in the diagnosis of hemolysis. Haptoglobin assays were performed shortly after admission in 100 patients with a variety of hematologic and nonhematologic conditions and the results correlated with the clinical diagnosis. An ad hoc boolean computer program allowed for the separation of hemolytic from nonhemolytic disorders with a haptoglobin limit of 25 mg/dL or less. The sensitivity and specificity of the test are high (83% and 96%, respectively), providing 87% probability of predicting hemolytic disease when the serum haptoglobin level falls below this limit. These data support the routine use of serum haptoglobin determinations in the diagnosis of hemolytic disease. (<i>JAMA</i>243:1909-1911, 1980)
Proctology
Authors: E. Parker Hayden
Journal: New England Journal of Medicine (1959)

TN this report I shall discuss a few points in the diagnosis and treatment of common lesions of the anus and rectum, and refer briefly to some of the pathologic conditions reported only occasionally. The last review on proctology appeared in this journal in the October 25 and November 1, 1956, numbers, and included references from 1954 through June of that year. This report carries on through November, 1958.General ConsiderationsSymptoms relating to the anal region are so coi imon that nearly everyone, sooner or later, experiences in greater or less degree some alteration in sensation or function. Minor . . .
The Future of Psychiatry
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Another database?
Authors: Angelo Pichierri, Venkat Iyer
Journal: Neuro-Oncology (2018)

We present an original database especially designed for healthcare professionals involved in the treatment and management of neuro-oncology patients. It was created by Mr AP (Neuro-oncology clinical fellow) on an idea by Mr RVI (Consultant Neurosurgeon) to meet the specific needs and requests directly collected from the end users. It is a homemade, low-cost solution which sits in a common folder of the Trust’s Server. Microsoft Access has been chosen as a platform because of its ubiquity on the computers of the Trust: authorized people can access, consult and input patient information from everywhere in the hospital. Surgeons, Oncologists, Radiotherapists, Speech and Language / Occupational Therapists, Physiotherapists, Specialist Nurses, Research Nurses, and Secretaries all have their own tabs for input within the patient’s electronic record: the content of these tabs is highly specific for neuro-oncology cases and it has been suggested by the individual specialist figures (for example, in the surgical tab there are templates for operative notes). Each patient’s record is completed with a tab containing all the patient’s electronic documents (including paper/email correspondence, intra-operative videos / snapshots). Quick links connect the database to the most common software products used in the hospital, including the Somerset Cancer Register. A tracking system allow to highlight patients awaiting for treatments, imaging or follow-up and discussion. Teaching cases can be easily filtered and selected as well. The proposed database is a dedicated, efficient and low-cost product for keeping neuro-oncology patients’ records tidy and in a single virtual place. It is a powerful and practical solution while awaiting for a professional software which could do the same and possibly even tightly integrating with PACS, the online on-call referral system and other online database (such as Somerset).
Abstract 892: Alterations of vitamin B1 homeostasis following oxidative stress in breast cancer and impact of supplementation on cellular redox homeostasis
Authors: Hunter C. Jonus, Ashley E. Ray, Jason A. Zastre
Journal: Cancer Research (2019)

Abstract Vitamin B1, or thiamine, has been demonstrated to enhance the development and growth of breast tumors in vivo. In addition, alterations in the expression of critical thiamine homeostasis genes have been extensively described in pre-clinical models of breast cancer as well as in clinical breast tumor tissue. Despite the effort that has been placed on delineating alterations to thiamine homeostasis that occur during breast cancer, there remains little evidence demonstrating a molecular advantage for supplemental thiamine in breast cancer cells. Our previous work in colorectal cancer suggests that the proliferative benefits of thiamine may be related to the maintenance of oxidative stress. This appears to be facilitated through the adaptive regulation of the thiamine activating enzyme thiamine pyrophosphokinase-1 (TPK1) for thiamine pyrophosphate production. Here, using MCF7 cells as a model of breast cancer, we also identified a relationship between thiamine homeostasis and oxidative stress. Similar to previous findings in colorectal cancer, Western blot analysis revealed that TPK1 expression was up-regulated in response to enhanced levels of ROS induced by hypoxia and chemotherapeutic treatment. TPK1 knockdown mediated by shRNA reduced the proliferation of MCF7 cells, while the presence of supplemental thiamine promoted proliferation as determined by cell counting. The effect of supplemental thiamine on MCF7 proliferation corresponded with a direct impact to the antioxidant status of tumor cells measured by reduced nuclear accumulation of the transcription factor nuclear factor- erythroid 2-related factor 2 by Western blot analysis. Molecular probes detecting intracellular ROS revealed that supplemental thiamine did not reduce the basal level of ROS in MCF7 cells. However, enhanced thiamine reduced intracellular superoxide levels following stimulation with the electron transport chain inhibitor Antimycin A. These findings support that during supplemental thiamine conditions thiamine homeostasis may be exploited in breast cancer for a redox advantage contributing to tumor progression. Citation Format: Hunter C. Jonus, Ashley E. Ray, Jason A. Zastre. Alterations of vitamin B1 homeostasis following oxidative stress in breast cancer and impact of supplementation on cellular redox homeostasis [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 892.
Magnetic resonance imaging.
Authors: R J Curtis
Journal: Annals of the Rheumatic Diseases (1991)

<b>BACKGROUND AND PURPOSE:</b> Spinal arteriovenous shunts usually require digital subtraction angiography (DSA) for evaluation. We report a unique time-resolved spinal MR angiographic (TRSMRA) technique with a temporal resolution of 3–6 seconds and spatial resolution of approximately 1 mm<sup>3</sup> that has the potential to noninvasively detect, localize, and follow-up these cases. <b>MATERIALS AND METHODS:</b> Eleven patients with clinical presentation and/or MR findings suspicious for a spinal arteriovenous shunt were referred for TRSMRA. Patients subsequently underwent spinal DSA to confirm the presence or absence of a shunt or were followed clinically until an alternative diagnosis was found. TRSMRA was also used to predict the level of the shunt in the positive cases. In addition, 2 of these patients as well as a 12th patient referred to us posttreatment received a follow-up TRSMRA to assess treatment outcome. <b>RESULTS:</b> Early venous shunting was identified by using TRSMRA in 6 cases. All 6 were confirmed to have an AV shunt on subsequent spinal DSA. The shunt level predicted by TRSMRA consistently correlated with DSA to within 1 vertebral level. In the 5 patients with a negative screening TRSMRA, DSA or clinical outcome confirmed the absence of an arteriovenous shunt in all of the cases. Posttreatment TRSMRA in 3 patients accurately assessed the success or failure of treatment. <b>CONCLUSION:</b> Combining acceleration techniques to achieve high frame rate TRSMRA provides sufficient temporal and spatial resolution to identify, localize, and follow patients suspected of having a spinal arteriovenous shunt. Further study in a larger population is warranted to assess the accuracy of this technique.