tbuckley/cabot-search huggingface dataset:
P05.89 Comparison of local control of brain metastases with stereotactic radiosurgery versus surgical resection: A secondary analysis of EORTC 22952–26001
Authors: S Weiss, T Churilla, I Chowdhury, E Handorf, L Collette, S Collette, B Alexander, M Kocher, R Soffietti, E Claus
Journal: Neuro-Oncology (2018)

We sought to evaluate local control of brain metastases among patients treated with stereotactic radiosurgery (SRS) versus neurosurgical resection within EORTC 22952. We performed a post-hoc analysis of EORTC 22952 and included patients treated per-protocol who had 1–2 brain metastases <4 cm. The primary endpoint was local recurrence (previously treated site) defined from time of randomization. We compared modality-specific local control by calculating cumulative incidence of local recurrence and competing risk regression to adjust for prognostic factors/competing mortality. Of 268 patients analyzed, 57.5% underwent SRS and 42.5% underwent surgical resection. Median follow-up was 13.5months. Compared to SRS, patients undergoing surgery had larger tumors (median 20mm vs. 28mm,p<0.001), more single brain metastases (74% vs. 98%,p<0.001), and different locations (p<0.001). Overall, SRS was associated with improved local control (p=0.015) in unadjusted analyses, but absolute differences in local control decreased with time (p<0.001 (interaction)). Unadjusted cumulative incidence of local recurrence by modality (SRS vs. surgery, respectively) are listed: 3months (2.0% vs. 15.8%), 6months (9.8% vs. 29.1%), 9months (17.0% vs. 35.4%), 12months (22.9% vs. 37.2%), and 24months (28.5% vs. 40.2%). Local control was similar by modality in the WBRT group (p=0.398) while SRS exhibited improved local control than surgery in the non-WBRT group (p=0.012). In adjusted models, surgical patients had a much higher early (0-3months) risk of local recurrence compared to SRS patients HR[95%CI]=5.94[1.72–20.45], but their risk decreased with time: 3-6months=1.37[0.64–2.90], 6-9months=0.75[0.28–2.00]. At >= 9months, local control appeared superior for surgery: 0.36[0.14–0.93]. Increased risk of local recurrence was also associated with increasing tumor size (p=0.031) and absence of extracranial disease (p=0.044). In this exploratory analysis, SRS appeared associated with improved early local control of treated lesions compared to patients treated surgically, although the relative benefit decreased with time. Variation in baseline patient characteristics limit this analysis warranting further study.
TCT CONNECT-376 A Novel Machine Learning Algorithm Enhances Prediction of Target Lesion Failure: An Analysis of 4,983 Patients From the XIENCE V USA Database
Authors: Divine Ediebah, Ciaran Byrne, Jin Wang, Richard Rapoza, James B. Hermiller, Mitchell Krucoff, Krishna Sudhir, Nick West
Journal: Journal of the American College of Cardiology (2020)
Bone scanning in osseous metastatic disease
Authors: R. E. O'Mara
Journal: JAMA (1974)

THE detection of metastatic disease to bone is critical in the management of patients with cancer. Bone involvement by carcinoma is a fairly common postmortem finding, exceeded in frequency only by metastases to lymph nodes, lungs, and liver.<sup>1,2</sup>The incidence of osseous metastases has been reported to be as high as 70% in some series of autopsies. This variance in reported incidence appears to depend on the thoroughness of the examination.<sup>3</sup>In the tumors that commonly metastasize to bone (breast, prostate, thyroid, lung, and kidney), incidence of secondary bone involvement at the time of death may range from 50% to 85%.<sup>4,5</sup>Both isotope and roentgenographic skeletal surveys are currently being used as means of achieving this detection. <h3>Scan vs Roentgenogram: Physiological Bases of Visualization</h3> There is general agreement that roentgenographic evidence of secondary malignant deposits in bone frequently appears late in the clinical course. While replacement of
Skin Flaps
Authors: Bradford Cannon
Journal: JAMA (1976)

The editors have assembled an international panel of experts to prepare this comprehensive, up-to-date book on skin flaps. The major divisions in the text are (1) some recent research on skin flaps to explain their survival or failure, and (2) clinical experiences with the selection, preparation, and uses of skin flaps in reconstructive surgery. Much evidence is garnered from experimental studies of flaps in animals. The pig is often selected because his skin and subcutaneous tissues resemble man's. For example, the evidence suggests that both in the experimental animal and in man, bleeding at the end of a long flap may be misleading. Raising the flap interrupts the sympathetic innervation of the arteriovenous channels, causing them to open. These channels are thick-walled and nonnutritative in contrast to the thin-walled capillaries that are now deprived of the normal blood flow. Thus the tissues through which they pass are deprived of normal
Error in Dose of Levothyroxine
Authors: Sheldon S. Stoffer
Journal: JAMA (1978)

<h3>To the Editor.—</h3> We were surprised to read in the QUESTIONS AND ANSWERS section (239:1205-1208, 1978) that the patient who had surgery for an autonomous hot thyroid nodule subsequently was treated with levothyroxine sodium (Synthroid), 0.5 mg/day. Our experience is consistent with Stock et al<sup>1</sup>and Cotton et al<sup>2</sup>in suggesting that the vast majority of hypothyroid patients are adequately treated, both from the clinical standpoint and in terms of restoration of elevated concentrations of serum thyroid-stimulating hormone to normal, with 0.2 mg or less of levothyroxine sodium daily. We have never found it necessary to exceed 0.3 mg/day. Therefore, we have questioned in the past the propriety of tablets too potent to be useful and perhaps too potent for human consumption.<sup>3,4</sup>We have encountered four patients for whom pharmacists erroneously dispensed tablets containing 0.5 mg rather than 0.05 mg of levothyroxine. Two of these patients had
International Medical Congress at Copenhagen.
Journal: JAMA (1884)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Studies in Medicine: A Volume of Papers in Honor of Robert Wood Keeton
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Circulating cytokine levels in hypertensive patients with left ventricular diastolic dysfunction without failure Timothy J. Regan, Albert Y. Sun, Charles Laham, Anita Raghuwanshi, Malthi R. Masurekar, Garikiparthy N. Jyothirmayi, Jing Liu. UMDNJ-New Jersey Medical School, Newark, NJ
Journal: Journal of the American College of Cardiology (2001)
Eradication of polio in the Americas
Authors: F. C. Robbins
Journal: JAMA (1993)

THERE IS good reason to believe that we are on the threshold of eradicating poliomyelitis from the Americas. There has not been a case of paralysis due to wild poliovirus identified in the Western Hemisphere for well over a year, the last identified case being in Peru in September 1991. However, many countries have been free of poliovirus for much longer. Since 1979 the United States has had no cases, except for the rare ones due to the live vaccine and an occasional imported case. The southern cone countries (Argentina, Chile, Paraguay, and Uruguay) have had no cases for 4 years or more, and the Caribbean islands and Costa Rica have equally good records. For editorial comment see p 1859. This most gratifying situation is the result of the decision in 1985 of the Pan American Health Organization to mount a campaign to eradicate polio. The success of the campaign
DINITROPHENOL POISONING
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
National Breast Cancer Awareness Month—October 1996
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fibrinolytic Mechanisms.
Authors: S. Sherry
Journal: Annals of Internal Medicine (1962)

s1 April 1962Fibrinolytic Mechanisms.S. Sherry, M.D., F.A.C.P., A. P. Fletcher, M.D., N. Alkjaersig, M.S.S. Sherry, M.D., F.A.C.P.Search for more papers by this author, A. P. Fletcher, M.D.Search for more papers by this author, N. Alkjaersig, M.S.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-56-4-690_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAs a result of recent studies, it is now apparent that fibrinolysis in man is a dynamic fundamental biological phenomenon, and that aberrations or imbalances in its mechanisms contribute importantly to the pathogenesis of certain clinical disorders. Conceptually, it already has achieved a status comparable to the coagulation mechanism. This report reviews and integrates current information concerning the fibrinolytic process in man, its mechanism of operation under physiological circumstances, and how abnormalities or imbalances in fibrinolytic phenomena contribute to the pathogenesis of certain clinical disorders.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: St. Louis, Mo. (ML) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1962Volume 56, Issue 4Page: 690-690KeywordsFibrinolysisPathogenesis Issue Published: 1 April 1962 PDF DownloadLoading ...
MOLLUSCUM SEBACEUM
Authors: E. GRAHAM-LITTLE
Journal: British Journal of Dermatology (1937)

Journal Article MOLLUSCUM SEBACEUM Get access E. GRAHAM‐LITTLE E. GRAHAM‐LITTLE Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 49, Issue 2, 1 February 1937, Page 92, https://doi.org/10.1111/j.1365-2133.1937.tb11161.x Published: 01 February 1937
American Journal of Clinical Pathology, Indianapolis, Ind
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Academic Dismissals: Due Process
Authors: Henry R. Arkin
Journal: JAMA (1985)

THE first part of this article discussed the<i>Horowitz</i>case and the procedural due process a school must follow before it can dismiss a student for academic reasons. Different from "procedural" due process is "substantive" due process, which is generally defined as the right to a decision that is not arbitrary or capricious. While the plurality opinion in<i>Board of Curators of the University of Missouri v Horowitz</i>, 98 SCt 948 (1978), only briefly and ambiguously referred to substantive due process, 98 SCt at 956, lower courts before and after<i>Horowitz</i>have held that under the US Constitution public institutions may not dismiss students for reasons that are arbitrary or capricious.<i>See generally Ewing v Board of Regents of the University of Michigan</i>, 559 FSupp 791, 797-798 (1983). The reluctance of courts to become involved is especially strong here, however, as academic expertise and discretion will be involved. In practice,
577. Inducible Regulation of Runx2-Stimulated Osteogenesis
Authors: Charles A. Gersbach, Joseph M. Le Doux, Robert E. Guldberg, Andres J. Garcia
Journal: Molecular Therapy (2006)

Introduction Cell-based approaches to bone regeneration often use gene therapy to induce osteogenesis in non-osteoblastic cells. However, unregulated overexpression of osteogenic proteins risks aberrant effects of uncontrolled signaling, including tumorigenesis and abnormal bone formation. Additionally, the incorporation of regulation into these systems allows for studying unique patterns of gene expression, including varying duration and magnitude, cycling of expression over time, and the sequential presence of multiple exogenous genes. We utilized a retroviral tetracycline-inducible system to modulate Runx2 expression and demonstrate regulation of mineralization in vitro and in vivo. This work is significant to developing controlled and effective gene therapy methods for tissue engineering, as well as novel strategies for investigating the effects of temporal modulation and magnitude of expression levels on osteoblastic differentiation. Methods Primary myoblasts were transduced with Runx2 and tTA retroviral stocks. Regulation of osteogenesis was evaluated by Western blotting, qRT-PCR, alkaline phosphatase activity, and matrix mineralization. Cells seeded on collagen scaffolds and implanted intramuscularly into hind limbs of syngeneic mice were analyzed for DNA content and mineralization by micro-CT, histology, and FT-IR. Results Cells expressed anhydrotetracycline (aTc)-dependent levels of Runx2 protein, as well as osteocalcin, bone sialoprotein, and osterix mRNA. Additionally, aTc levels regulated mineralization by these cells, as shown by alkaline phosphatase activity, von Kossa staining, and calcium content (Fig. 1A). FT-IR spectroscopy confirmed this mineral to be biological hydroxyapatite. Osteocalcin expression and mineralization were upregulated in response to removal of aTc, and were repressed when aTc was replaced, demonstrating temporal regulation of osteogenesis (Fig. 1B). These cells also demonstrated aTc-dependent mineralization in vivo (Fig. 2).Fig. 2View Large Image Figure ViewerDownload Hi-res image Download (PPT) Conclusions We have stimulated osteogenesis in a Runx2- dependent manner. This conversion to a osteoblastic phenotype is inducible, repressible, and recoverable after suppression. Regulated mineralization was evident in both 2D and 3D settings in vitro, as well as ectopically in vivo. These results present a novel combination of Runx2 and tetracycline-regulated gene expression as a promising, controllable, and effective approach to bone tissue engineering and addressing limitations of constitutive gene therapy. Additionally, this system is useful for elucidating time- and dose-dependent biological mechanisms of Runx2-stimulated osteogenesis.
HEPATIC FUNCTION AT HIGH ALTITUDE
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE ETIOLOGY OF PERTUSSIS AND ITS SERUM TREATMENT.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Erratum: <i>Daclatasvir plus sofosbuvir, with or without ribavirin, achieved high sustained virological response rates in patients with HCV infection and advanced liver disease in a real-world cohort</i>
Journal: Gut (2016)

Erratum: Daclatasvir plus sofosbuvir, with or without ribavirin, achieved high sustained virological response rates in patients with HCV infection and advanced liver disease in a real-world cohort
Radium and Cancer: A Monograph
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal