tbuckley/cabot-search huggingface dataset:
Abstract 4405: Acetylation of KLF5 controls the cell fate of basal progenitors during postnatal development and regeneration of mouse prostates
Authors: Baotong Zhang, Jin-Tang Dong
Journal: Cancer Research (2019)

Abstract Adult stem cells are responsible for lineage specification in epithelial homeostasis, and thus are essential for both postnatal development and tissue regeneration. Genetic changes in adult stem cells have been revealed to promote cancer development. Dissecting the underlying regulators is critical for understanding the intrinsic mechanisms that regulate adult stem cell function, yet whether PTM of a single molecule determines cell fate of adult stem cells during organ development has not been well established, particularly for glandular organs. Using the androgen-dependent mouse prostate as an experimental system, an ideal system for understanding epithelial hierarchy, we examined the Krüppel-like factor 5 (Klf5) transcription factor and its acetylation for their roles in postnatal development and regeneration. The absence of KLF5 eliminated basal progenitor activities in both human and mouse prostate epithelial cells, as indicated by a compromised sphere and organoid formatting capabilities, downregulation of basal cell markers, and decreased basal cells. Klf5 was also necessary for basal progenitor cells to maintain their luminal differentiation capacity, as loss of Klf5 also decreased basal progenitor-derived luminal cells and their proliferation in mouse prostates. Interestingly, the progenitor activity of Klf5 was restricted to deacetylated Klf5 (deAc-Klf5), as indicated by in vitro and in vivo assays. On the other hand, acetylated Klf5 (Ac-Klf5) was essential for proper formation and maintenance of luminal structures in mouse prostates, as deacetylation of Klf5 interrupted the formation of normal luminal structures, almost eliminated the castration resistance in basal progenitor-derived luminal cells, and attenuated the luminal regeneration after a castration-regeneration cycle, even though deAc-Klf5 promoted basal-to-luminal differentiation and the proliferation of luminal cells during postnatal development. Mechanistically, deacetylation of Klf5 increased Notch signaling activity. These findings indicate that Klf5 and its acetylation control the cell fate of prostatic basal progenitors, which have a distinct contribution to postnatal development and regeneration of the prostate. Considering that androgen deprivation therapy (ADT) is currently a major therapeutic strategy in the treatment of prostate cancer, our findings also provide a potential mechanism for prostate cancer progression, i.e., interruption of Klf5 acetylation could sensitize castration-resistant prostate cancer to ADT or slow the recurrence of prostate cancer after ADT. Citation Format: Baotong Zhang, Jin-Tang Dong. Acetylation of KLF5 controls the cell fate of basal progenitors during postnatal development and regeneration of mouse prostates [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4405.
Dialysis and transplantation in young children.
Journal: BMJ (1979)

Dialysis and transplantation in young childrenIn spite of all the publicity, fund raising, and political pressure many adults and children who develop chronic renal failure in Britain are still not offered treatment with dialysis or transplantation.'The latest report from the European Dialysis and Transplant Association Children's Register (for the year ending December 1977) shows that 39 children under the age of 15 years were accepted for treatment in Britain during the year2-a rate of 0 7 children per million total population compared with the estimated requirement of 1-3 per million -and there has been no improvement over the last four years.The 39 children accepted were treated in 18 different centres, though among them four paediatric units accounted for 23 of the 39.Three of these four units have the facilities for children recommended in a report on the provision of care for children prepared by the British Association of Paediatric Nephrology in 19743: the other children were treated in adult centres with varying skills in paediatric medicine.Children treated in adult centres tend to be older than those treated in paediatric centres,4 and, because of the inadequate resources available for children and the reliance on adult centres, few younger children are accepted for treatment.By the end of 1977 of a total of 288 children who had ever been treated in Britain only five had been aged under 5 at the start.In contrast, in France 32 children under 5 have been accepted for treatment since 1969,5 and these younger children now account for 10O0 of all children treated.In all, 87 children aged under 5 have been treated in Europe.6This -failure to treat children cannot be justified on clinical grounds.Patient and graft survival is better in children than in any adult age group,2 and there is some suggestion that rejection may be less common.2So far results have been better in centres with paediatric facilities than in those without.2The overall patient survival in Europe after three years' treatment with home dialysis was 88" , with a survival of 7700, for recipients of living donor and 7400 for recipients of cadaver grafts2: at three years living donor graft survival was 6200 and cadaver graft survival 470 .Half of all the children in Europe treated 10 or more years ago were alive in 1978.2Fine et a18 reported a five-year survival of 78% in 69 transplanted children, with a living donor graft survival of 7300 and first-cadaver-graft survival of 3500.The European data show a patient survival of 7700 at two years in
Neural networks as predictors of outcomes in alcoholic patients with severe liver disease
Authors: P Lapuerta
Journal: Hepatology (1997)

We developed and evaluated neural networks as predictors of outcomes in alcoholic patients with severe liver disease using commonly available clinical and laboratory values. Hospital charts of 144 patients were reviewed. Nine variables (five laboratory, four clinical) were recorded along with in-hospital death or survival. Data were organized into separate development and validation sets. Neural network predictions of survival were compared with those of the Maddrey discriminant function and logistic regression models developed on the same data. Model performance was evaluated by comparing areas under receiver-operating characteristic (ROC) curves and the distributions of model scores. Survivors had significantly different laboratory and clinical characteristics, the most important being a higher prothrombin time, lower bilirubin, and lower incidence of encephalopathy. Neural network performance was significantly better than that of the Maddrey score (ROC areas, 81.5% vs. 73.8%; P = .04). The ROC area for neural networks was similar to that of logistic regression (ROC area 78.2%; P = .3), but the neural networks were more successful in classifying patients into low- and high-risk groups (P < .001). A neural network score with laboratory data from hospital-day 7 improved prognostic accuracy further to 84.3%. After adjusting for baseline risk, the neural network change in illness severity was still a significant predictor of mortality (P = .001). Neural networks using clinical and laboratory data showed a high prognostic accuracy for predicting mortality in alcoholic patients with severe liver disease.
ILLINOIS STATE MEDICAL SOCIETY.
Journal: JAMA (1889)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Truth telling in medicine
Authors: M. Sheldon
Journal: JAMA (1982)

TRUTH TELLING is, of course, a very broad topic at issue extensively in the practice of medicine. It does not pertain only to communication between physician and patient, but also, for instance, to matters of confidentiality, to candid evaluation of one's peers, and to the use of placebos. There are also instances of physicians who become involved in acts of civil disobedience, even if the acts are not known to the civil authority. For example, there were physicians against the war in Vietnam who, as a matter of principle, falsified medical records to enable certain individuals to escape service in the war. There were also physicians who falsified the health records of particular children so these children could avoid being transported across town to achieve court-ordered racial integration. The focus of this article, however, will be limited to the issue of communication between physician and patient. This is not a
Medical Practice in Australia.
Authors: None P. M. K.
Journal: JAMA (1900)

reported on the monthly reports of troops serving in the Pacific islands, and 32 of these, or 33.3 per cent., were sent to the Government Hospital for the Insane.Seventeen cases, or 53.1 per cent., of those committed recovered in an average period of 3.6 months, 2 were improved, 2 died and 11 remained not improved.It is not deemed necessary to do more than present these official figures to silence the sensational newspaper paragraphs which have been published during the past year relative to the unusual number of cases of insanity which have been re¬ turned to the United States from our troops operating in the Philippine Islands.Respectfully,
"PROGRESSION OF SNORING AND OBSTRUCTIVE SLEEP APNOEA: THE ROLE OF INCREASING WEIGHT AND TIME". G. BERGER, R. BERGER AND A. OKSENBERG. EUR RESPIR J 2009; 33: 338-345.
Journal: European Respiratory Journal (2009)

Unfortunately, some of the information and numerical values in the abstract of this study were presented incorrectly.In the third paragraph of the abstract, the second sentence should have appeared as follows: ''The cumulative effect per uC increase was 0.79% below and 0.88% above a threshold (21.3uC) after a winter with low cardiovascular and respiratory mortality, but modified with -0.29% below and -0.04% above the threshold after a winter with high cardiovascular and respiratory mortality.''The authors apologise for this error.
Twentieth Century Practice. An International Encyclopedia of Modern Medical Science, by Leading Authorities of Europe and America.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
African Refugee Disasters Increase the Risk of Blindness
Authors: Naushad Hussein
Journal: JAMA (1995)

<h3>To the Editor.</h3> —Reports of the crisis in Rwanda make it plain that African refugee disasters are accompanied by excessive mortality.<sup>1</sup>We present evidence that risk of blindness is dramatically increased as well. In 1987, 2 years after the Ethiopian famine, we performed eye studies in the refugee camps of the eastern Sudan. In addition to random cluster surveys for blindness, we directed particular attention to corneal scars, as a proxy for the uncommon event of blindness. If a person had a corneal scar, it was reasonable to assume that the person had sustained a potentially blinding illness, such as serious eye infection, xerophthalmia, or trauma. We were interested to see if there was evidence that the catastrophic shearing of the social fabric caused by the refugee disaster could be related to the prevalence or incidence of corneal scar. We compared children orphaned by the refugee crisis with children
Two-Hour Methyl Isocyanate Inhalation Exposure and 91-Day Recovery: A Preliminary Description of Pathologic Changes in F344 Rats
Authors: J. R. Bucher, G. A. Boorman, B. N. Gupta, L. C. Uraih, L. B. Hall, S. A. Stefanski
Journal: Environmental Health Perspectives (1987)

The accidental release of methyl isocyanate (MIC) in Bhopal, India, was reportedly responsible for the deaths of more than 2,000 people. To study the pathology of acute inhalation exposure to MIC, the tissues of male and female Fischer 344 rats were evaluated immediately after a single 2-hr exposure to 0, 3, 10, or 30 ppm MIC, and through day 91. Early gross pathologic changes in the 30 ppm-exposed rats included a reddish white encrustation around the mouth and nose, a small thymus, and distension of the gastrointestinal tract with gas. Lungs (middle and median lobes) showed consolidation and hemorrhage and failed to deflate when the chest cavity was opened. Microscopic changes in the upper respiratory tract 3 hr after exposure included marked erosion and separation of olfactory and respiratory epithelia from the basement membrane with accumulation of serofibrinous fluid. On day 1, acute inflammation and fibrinopurulent exudate partially blocked the nasal passages. Epithelial cells had sloughed from the nasopharynx, trachea, bronchi, and major bronchioles, leaving the basement membrane covered with fibrin and exudate. Granulomatous inflammation and intraluminal fibrosis of the airways were observed by day 3, with increased intraluminal fibrosis by day 7. Lower airways became blocked by exfoliated cells, mucous plugs, and/or intraluminal fibrosis.(ABSTRACT TRUNCATED AT 250 WORDS)
Toward Manhood
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE SCIENTIFIC ASPECTS OF MEDICAL HYPNOTISM, OR TREATMENT BY SUGGESTION.Read before the Chicago Medico-Legal Society, October 4, 1890.
Authors: M. H. LACKERSTEEN
Journal: JAMA (1890)

(Concluded from page 708.) I wish now to say a few words from my own knowledge of the subject. My experience, has been very limited in regard to hypnotic therapeutics, and it is only as a therapeutic measure that I have any knowledge of hypnotism at all. Some thirty years ago, about the termination of the Sepoy mutiny in India, I visited the mesmeric hospital which had been established in Cal cutta, by Dr. Esdaile, many years before my time, and witnessed a capital operation on a na tive who had been put into the mesmeric trance. On the following week I repeated my visit with the surgeon in charge ofthe hospital, and by his kindness and courtesy, I had the opportunity of performing two operations, an amputation of the thigh, and the removal of a scrotal tumor, which was found to weigh a little above fifty pounds. Both these
Medical Gymnastics in Medicine and Surgery.
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fibromyalgia syndrome. An emerging but controversial condition
Authors: D. L. Goldenberg
Journal: JAMA (1987)

The clinical manifestations, laboratory findings, and treatment results of 118 patients with fibromyalgia followed up by one investigator were compared with those of other recent reports. The history of this syndrome and recent efforts to establish diagnostic criteria and to understand underlying pathophysiologic mechanisms were studied. A practical, noninvasive office-based evaluation and conservative treatment approach were developed, determined by an understanding of the natural history of this common but controversial disorder. (<i>JAMA</i>1987;257:2782-2787)
Highlights
Journal: JAMA Surgery (2019)

Information provided by the narrative operative report is subjective and often flawed.In this prospective observational cohort study of 113 surgical cases, the authors investigated the use of systematic video recording as a potential improvement in quality and safety with regard to documenting important information in colorectal cancer surgery.Compared with narrative reports alone, systematic video recording was shown to be superior. Invited Commentary 389Adhesive Small-Bowel Obstruction Surgery and Recurrence Risk 413Adhesive small-bowel obstruction is a potentially chronic, recurring illness that can require surgical care.In a population-based cohort study, Behman and colleagues compared the risk of recurrence in patients who received operative vs nonoperative management of this condition.Patients who were managed operatively had a lower risk of recurrence than those managed nonoperatively.The probability of additional recurrences increased with each nonoperatively managed episode until surgical intervention, at which point the risk of subsequent recurrence decreased by approximately 50%.
CONNECTICUT STATE MEDICAL SOCIETYOne Hundred and Eighteenth Annual Meeting, held at New Haven May 25-26, 1910
Journal: JAMA (1910)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Long-term follow-up of thoracoscopic talc pleurodesis for primary spontaneous pneumothorax
Authors: V. Steger, T. Walles, T. Walker, G. Friedel
Journal: European Respiratory Journal (2007)

Long-term follow-up of thoracoscopic talc pleurodesis for primary spontaneous pneumothoraxTo the Editors:I read with interest the study by GYO ¨RIK et al.[1] of talc pleurodesis for primary spontaneous pneumothorax.The results were not surprising as they confirm previous studies.What was surprising, however, was the lack of a control group, the lack of an intention-to-treat analysis and the failure of the paper's discussion to mention these absences as a weakness.The authors report a 95% long-term success rate for talc pleurodesis, which represents 53 out of 56 patients initially treated successfully with the technique.There were, however, 112 patients who underwent the procedure.The authors were only able to contact 63 of them; the remaining 49 apparently were not contactable because of ''geographical movement.''I am troubled that an intention-to-treat analysis is not reported.Given the 53 long-term successes and 112 original treatments, I arrive at a success rate of 47%, which is half of what the authors report.Together with the lack of a control group of patients who suffered spontaneous pneumothoraces but did not undergo talc pleurodesis, I find it unclear as to what can be reliably concluded from this study.