tbuckley/cabot-search huggingface dataset:
A Kinase-Independent Function of CDK6 Links the Cell Cycle to Tumor Angiogenesis
Authors: Karoline Kollmann, Gerwin Heller, Christine Schneckenleithner, Wolfgang Warsch, Ruth Scheicher, Rene G. Ott, Markus Schäfer, Sabine Fajmann, Michaela Schlederer, Ana-Iris Schiefer, Ursula Reichart, Matthias Mayerhofer, Christoph Hoeller, Sabine Zöchbauer-Müller, Dontscho Kerjaschki, Christoph Bock, Lukas Kenner, Gerald Hoefler, Michael Freissmuth, Anthony R. Green, Richard Moriggl, Meinrad Busslinger, Marcos Malumbres, Veronika Sexl
Journal: Cancer Cell (2016)

(Cancer Cell 24, 167–181; August 12, 2013) In the original Figure 3C, the files from patient B were accidentally uploaded twice for patient B and patient C. The corrected files for patient C have been corrected in the figure below. The authors apologize for any confusion this may have caused the readers. A Kinase-Independent Function of CDK6 Links the Cell Cycle to Tumor AngiogenesisKollmann et al.Cancer CellAugust 12, 2013In BriefIn contrast to its close homolog CDK4, the cell cycle kinase CDK6 is expressed at high levels in lymphoid malignancies. In a model for p185BCR-ABL+ B-acute lymphoid leukemia, we show that CDK6 is part of a transcription complex that induces the expression of the tumor suppressor p16INK4a and the pro-angiogenic factor VEGF-A. This function is independent of CDK6’s kinase activity. High CDK6 expression thus suppresses proliferation by upregulating p16INK4a, providing an internal safeguard. However, in the absence of p16INK4a, CDK6 can exert its full tumor-promoting function by enhancing proliferation and stimulating angiogenesis. Full-Text PDF Open Access
LETTER FROM PARIS.
Authors: None A. B.
Journal: JAMA (1890)

(FROM OUR REGULAR CORRESPONDENT.) <i>Experiments demonstrating that Physical Fatigue is a powerful factor in the Production of Infectious Diseases—The Etiology of Asthenopia— Treatment of Endometritis by the Curettage of the Uterus—On Spontaneous Fracture in Tabetic Subjects—A Formula for an Antiseptic Paper</i>. In a note by Drs. Charrin and Roger published in the<i>Revue Sciéntifique</i>, the authors endeavored to afford experimental confirmation of the generally received view that physical fatigue is a powerful factor in the production of infectious disease. They subjected a number of white rats to severe exercise (running in a rotating cage) for four consecutive days, at seven hours each day. Eight of these tired out animals were then inoculated with attenuated anthrax virus, four animals in a normal condition of health being inoculated with the same virus at the same time, in order to serve as a standard of comparison. The result was, that seven of the
W[ill]rden und Wirken eines deutschen Frauenarztes. Lebenserinnerungen.
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Stenting elderly patients in the new milleniium: Results in the year 2000 Yoshio Kobayashi, George Dangas, Roxana Mehran, Issam Moussa, Gishel New, Octavia Balan, Gary S. Roubin, Sriram Iyer, Nadim Al-Mubarak, Nancy Cohen, Gregg W. Stone, Martin B. Leon. Lenox Hill Heart and Vascular Institute, New York, NY, Cardiovascular Research Foundation, New York, NY
Journal: Journal of the American College of Cardiology (2001)
NOSTRUM ADVERTISEMENTS ON DRUGGISTS' WRAPPING PAPER.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
DNA Adducts as a Dosimeter for Risk Estimation
Authors: Steven A. Belinsky, Catherine M. White, Theodora R. Devereux, Marshall W. Anderson
Journal: Environmental Health Perspectives (1987)

The dose response for O6-methylguanine (O6MG) formation and cytotoxicity was determined in lung and nasal mucosa from Fischer 344 rats during multiple dose administration of the tobacco-specific nitrosamine-4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK). O6MG accumulated in the lung following treatment for 12 days with doses of NNK from 0.3 to 100 mg/kg/day. The dose response for NNK was nonlinear; the O6MG-to-dose ratio, an index of alkylation efficiency, increased dramatically as the dose of carcinogen decreased. These data suggest that low- and high-Km pathways may exist for activation of NNK to a methylating agent. Marked differences in O6MG concentration were observed in specific lung cell populations. The Clara cell, one of the suggested progenitor cells for nitrosamine-induced neoplasia, was found to possess the greatest concentration of O6MG. Moreover, as the dose of NNK was decreased from 100 to 0.3 mg/kg, the alkylation efficiency in this cell population increased 38-fold. The presence of a high-affinity pathway in the Clara cell for activation of NNK may contribute to the potent carcinogenicity observed following low-dose exposure to this tobacco-specific carcinogen. The dose response for O6MG formation differed considerably between the respiratory and olfactory mucosa from the nasal passages of the rat. The dose response was nonlinear in respiratory mucosa but linear in olfactory mucosa. The alkylation efficiency increased dramatically only in the respiratory mucosa as the dose of NNK was decreased. These studies suggest that a low Km pathway for NNK activation is also present in the nose and that this pathway is localized predominantly in the respiratory region.(ABSTRACT TRUNCATED AT 250 WORDS)
Lactic Dehydrogenase in Rheumatoid Arthritis
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Early-drug development in the era of immuno-oncology: are we ready to face the challenges?
Authors: M.O. Ochoa de Olza, M. Oliva, C. Hierro, I. Matos, J. Martin-Liberal, E. Garralda
Journal: Annals of Oncology (2019)

Ann Oncol 2018; 29: 1727–1740 (doi: 10.1093/annonc/mdy225) The funding statement has been corrected to read “This research has been funded by the Comprehensive Program of Cancer Immunotherapy & Immunology (CAIMI) supported by the Banco Bilbao Vizcaya Argentaria Foundation (FBBVA) (grant 89/2017).” Early-drug development in the era of immuno-oncology: are we ready to face the challenges?Annals of OncologyVol. 29Issue 8PreviewThe classical development of drugs has progressively faded away, and we are currently in an era of seamless drug-development, where first-in-human trials include unusually big expansion cohorts in the search for early signs of activity and rapid regulatory approval. The fierce competition between different pharmaceutical companies and the hype for immune combinations obliges us to question the current way in which we are evaluating these drugs. In this review, we discuss critical issues and caveats in immunotherapy development. Full-Text PDF Open Archive
Mandatory National Health Service
Authors: Walter F. Tauber
Journal: JAMA (1993)

<h3>To the Editor.</h3> —It is easy for the vice president of medicine at Johns Hopkins University to call for mandatory national health service.<sup>1</sup>It would be equally easy for those of us who are no longer at risk of being called to concur. I do not know whether such involuntary servitude would be against the letter of the servitude clause of the Constitution. It surely denies its spirit.
Battles continue over DES use in fattening cattle
Authors: P. Gunby
Journal: JAMA (1980)

Federal investigators are uncovering widespread disregard of the Food and Drug Administration's ban on use of diethylstilbestrol (DES) to help slaughter animals gain weight (<i>JAMA</i>[MEDICAL NEWS] 242:1010, 1979). In the meantime, alternative compounds for this purpose are under study. The FDA officials say the illegal use of DES so far involves more than 420,000 cattle, some 30,000 of which already have been slaughtered. Some violators may be prosecuted, and the US Department of Agriculture (USDA) is increasing surveillance to prevent further violations. The FDA and the USDA contend that "DES is a known carcinogen in both animals and humans" and that "DES residues have been found in animals intended for human food." All this results from an FDA decision of about a year ago in which the agency declared the following: Effective July 13, 1979, DES was not to be manufactured or shipped. (Some manufacturers since have filed suit,
Antiseptics To Prevent Infection from Intravascular Catheters
Journal: Annals of Internal Medicine (2002)

Summaries for Patients4 June 2002Antiseptics To Prevent Infection from Intravascular CathetersSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-136-11-200206040-00002 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Catheters are small, flexible plastic tubes. They are commonly inserted into veins or arteries (intravascularly) to deliver fluid or drugs directly into the bloodstream or to help perform special tests. Intravascular catheters are normally inserted through the skin. The skin's surface has bacteria that can cause infection. Antiseptic preparations are used to clean the skin around the area where catheters are inserted. These preparations contain chemicals that kill or prevent growth of bacteria. The main aims of antiseptic use are to “disinfect skin” and to stop bacteria from ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Chlorhexidine Compared with Povidone-Iodine Solution for Vascular Catheter-Site Care: A Meta-Analysis.” It appears in the 4 June 2002 issue of Annals of Internal Medicine (volume 136, pages 792-801). The authors are N Chaiyakunapruk, DL Veenstra, BA Lipsky, and S Saint.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoChlorhexidine Compared with Povidone-Iodine Solution for Vascular Catheter–Site Care Nathorn Chaiyakunapruk , David L. Veenstra , Benjamin A. Lipsky , and Sanjay Saint Metrics 4 June 2002Volume 136, Issue 11Page: I-26KeywordsArteriesBacteremiaBacteriaCathetersDrugsIntensive care unitsPatientsRandomized trialsSkin infectionsVeins ePublished: 4 June 2002 Issue Published: 4 June 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Genes V
Authors: James R. Lupski
Journal: JAMA (1995)

The fifth edition of this well-established classic textbook in molecular genetics is a "must read" for individuals, including medical students, residents, fellows, and attending physicians, interested in medical and human genetics. It will also be useful for practicing physicians with little knowledge of molecular genetics who wish to gain a better understanding of the excitement conveyed in the lay press regarding disease gene identification and the Human Genome Project, but who don't know where to start to obtain the necessary background. It certainly has become apparent over the past several years that the tools of genetics and molecular biology are playing an ever-increasing role in understanding the mechanisms of disease processes. This is true not only for single-gene disorders that segregate in a Mendelian fashion, but also in diseases for which there are inherited susceptibilities, such as cancer and heart disease. In addition, molecular genetic methodologies are having direct impact
MIGRAINE THERAPY
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Membrane potential of hepatic mitochondria after acute cocaine administration in rats?The role of mitochondrial reduced glutathione
Authors: A Masini, D Gallesi, F Giovannini, T Trenti, D Ceccarelli
Journal: Hepatology (1997)

ABSTRACT Cocaine hepatotoxicity may be mediated by oxidative damage, possibly involving mitochondrial injury. The effect of an acute dose of cocaine in rats on the mitochondrial level of reduced glutathione, nicotinamide adenine dinucleotide (NADH) and nicotinamide adenine dinucleotide phosphate (NADPH), important determinants in cellular defense against oxidative stress, was investigated. Under these conditions, the extent of lipid peroxidation was assessed as thiobarbituric acid reactive substances formation and the energy transducing capability of the inner mitochondrial membrane was evaluated by membrane potential measurements. Female Wistar albino rats were given an acute 50 mg/kg intraperitoneal dose of cocaine and, 6 hours later, hepatic and mitochondrial biochemical analyses were made. Rats administered intraperitoneally, 7.5 hours before the sacrifice, a specific inhibitor of glutathione synthesis, l–buthionine–(S,R)–sulphoximine, either alone or in combination with cocaine, underwent in parallel the same determinations. Cocaine intoxication did not impair mitochondrial functions, although a significant increase of lipid peroxidation occurred. By contrast the combination of l–buthionine–(S,R)–sulphoximine with cocaine induced a severe derangement of mitochondrial functional efficiency, a large depletion of reduced glutathione, and a further enhancement of lipid peroxidation. The mitochondrial functional anomalies were largely restored by the use of cyclosporin A, ethyleneglycotetraacetic acid (EGTA) and glutathione methylmonoester. A nonspecific calcium dependent inner membrane permeabilty transition (pore opening) accounted for the partial loss of mitochondrial coupled functions at a period of cocaine intoxication when no cell damage occurred. The level of mitochondrial glutathione played a critical role in protecting inner membrane functional integrity against cocaine–induced oxidative stress.
Retrograde cannulation of cephalic vein for hemodialysis
Authors: V. P. Rao
Journal: JAMA (1970)

An arteriovenous shunt has now been functioning three years with the use of one radial artery and multiple revisions along the cephalic vein. Retrograde cannulation of the cephalic vein has materially added to the survival of this shunt. We describe the technique here in hope that it will be useful to others presented with the same problem.
Movies
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Function Of Synaptic Transmitters In The Retina
Authors: N. Daw
Journal: Annual Review of Neuroscience (1989)

The brain's default mode network consists of discrete, bilateral and symmetrical cortical areas, in the medial and lateral parietal, medial prefrontal, and medial and lateral temporal cortices of the human, nonhuman primate, cat, and rodent brains. Its ...Read More
OBJECTIONABLE PHOTOGRAPHS.
Authors: N.S. Davis
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Guidelines for admission of alcohol-dependent patients to general hospitals
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effect of a Low-Fat Diet on Hormone Levels in Women With Cystic Breast Disease
Journal: JNCI Journal of the National Cancer Institute (1987)

Journal Article Effect of a Low-Fat Diet on Hormone Levels in Women With Cystic Breast Disease Get access Carr J. Smith, Ph.D. Carr J. Smith, Ph.D. R.J. Reynolds Tobacco CompanyWinston-Salem, North Carolina 27102 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 79, Issue 3, September 1987, Page 607, https://doi.org/10.1093/jnci/79.3.607 Published: 01 September 1987