PENICILLIN IN THE TREATMENT OF SYPHILIS
Authors: F. W. R.
Journal: Annals of Internal Medicine (1947)

Editorial1 January 1947PENICILLIN IN THE TREATMENT OF SYPHILISF. W. R.F. W. R.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-26-1-148 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptLike many another new form of therapy, the penicillin treatment of syphilis has progressed through the cycle of dubiety, enthusiasm and reaction. Mahoney's original report1that penicillin is effectual againstT. pallidumwas received with some caution, but as laboratory and clinical confirmation of this observation rapidly became available, reserve quickly gave way to enthusiasm. So promising did this new form of therapy appear that in September 1943, within three months of the first public announcement, a nationwide cooperative study was organized under the auspices of the Committee on Medical Research. In less than a year penicillin was adopted for...1 MAHONEYARNOLDHARRIS JFRCA: Penicillin treatment of early syphilis: preliminary report, Ven. Dis. Inform., 1943, xxiv, 355. Google Scholar2 News and Comments: Status of penicillin treatment of early syphilis, Bull. U. S. Army Med. Dept., 1946, v, 1. Google Scholar3 MCDERMOTTBENOITDUBOIS WMR: Time-dose relationships of penicillin therapy: regimens used in early syphilis, Am. Jr. Syph., Gonor. and Ven. Dis., 1945, xxix, 345. Google Scholar4 EAGLEMAGNUSONFLEISCHMAN HHJR: The effect of the method of administration on the therapeutic efficacy of sodium penicillin in experimental syphilis, Bull. Johns Hopkins Hosp., 1946, lxxix, 168. Google Scholar5 ROMANSKYRITTMAN MJGE: Method of prolonging action of penicillin, Science, 1944, c, 196. CrossrefGoogle Scholar6 KOCH RA: Ambulatory intensive treatment of syphilis with calcium penicillin in oil and wax, Urol. and Cut. Rev., 1946, 1, 461. Google Scholar7 ROMANSKYREIN MJCR: Treatment of early syphilis with calcium penicillin-oil-beeswax, Jr. Am. Med. Assoc., 1946, cxxxii, 847. CrossrefGoogle Scholar8 Committee on Medical Research and the United States Public Health Service: The treatment of early syphilis with penicillin, Jr. Am. Med. Assoc., 1946, cxxxi, 265. Google Scholar9 Editorial: The changing concept of reinfection with syphilis and its applicability as a criterion of cure, Am. Jr. Syph., Gonor. and Ven. Dis., 1945, xxix, 474. Google Scholar10 EAGLEMAGNUSONFLEISCHMAN HHJR: The synergistic action of penicillin and mapharsen (oxophenarsine hydrochloride) in the treatment of experimental syphilis, Jr. Ven. Dis. Inform., 1946, xxvii, 3. Google Scholar11 DATTNERTHOMASWEXLER BEWG: The management of neurosyphilis, 1944, Grune and Stratton, New York. CrossrefGoogle Scholar12 MOOREMOHR JECF: Penicillin in the treatment of neurosyphilis. I. Asymptomatic neurosyphilis, Am. Jr. Syph., Gonor. and Ven. Dis., 1946, xxx, 405. Google Scholar13 REYNOLDSMOHRMOORE FWCFJE: Penicillin in the treatment of neurosyphilis. III. Changes in cerebrospinal fluid abnormalities, Ann. Int. Med. (In press.) Google Scholar14 NELSONMOORE RAJE: Acute syphilitic meningitis treated with penicillin: a progress report, Am. Jr. Syph., Gonor. and Ven. Dis., 1946, xxx, 227. Google Scholar15 REYNOLDSMOHRMOORE FWCFJE: Penicillin in the treatment of neurosyphilis. II. Dementia paralytica, Jr. Am. Med. Assoc., 1946, cxxxi, 1255. CrossrefGoogle Scholar16 CHESNEYREYNOLDS LPFW: Penicillin in the treatment of neurosyphilis. IV. Tabes dorsalis. To be published. Google Scholar17 TUCKER HA: Penicillin treatment of Erb's syphilitic spinal spastic paraplegia, Bull. Johns Hopkins Hosp., 1946, lxxviii, 161. Google Scholar18 ROSETREVETTHINDLEPROUTSOLOMON ASLDJACHC: Penicillin treatment of neurosyphilis, Am. Jr. Syph., Gonor. and Ven. Dis., 1945, xxix, 487. Google Scholar19 DEXTERTUCKER DDHA: Penicillin treatment of benign late gummatous syphilis: a report of twenty-one cases, Am. Jr. Syph., Gonor. and Ven. Dis., 1946, xxx, 211. Google Scholar20 TUCKERDEXTER HADD: Treatment of gummatous hepatic syphilis with penicillin: Report of two cases, Arch. Int. Med., 1946, lxxviii, 313. CrossrefGoogle Scholar21 GOODWINMOORE MSJE: Penicillin in prevention of prenatal syphilis, Jr. Am. Med. Assoc., 1946, cxxx, 688. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 January 1947Volume 26, Issue 1Page: 148-153KeywordsClinical laboratoriesPenicillinResearch laboratoriesSyphilis ePublished: 1 December 2008 Issue Published: 1 January 1947 PDF downloadLoading ...