tbuckley/cabot-search huggingface dataset:
The foreskin saga
Authors: J. R. Harnes
Journal: JAMA (1971)

A recent article, "Whither The Foreskin"<sup>1</sup>again questions the value of circumcision, a problem bandied by physicians for years. It also calls to attention that this subject lends itself to some fanciful titles for medical articles, eg, "Penile Plunder,"<sup>2</sup>"The Fate of The Foreskin,"<sup>3</sup>and "The Rape of the Phallus,"<sup>4</sup>a group I feel justified in joining. In June 1965, Morgan<sup>4</sup>attacked circumcision as barbarous (Iagree), of no health value (I am shocked), and resulting in decreased sexual pleasure in the male (I am depressed). I am certain that I was not alone among the circumcised readers of that article in becoming quite concerned. My father was a young physician at the time of my circumcision and presumably had it done with best intentions. Nonetheless, although I am not a psychiatrist, a number of questions came to my mind. Did this represent an unconscious attack
Turning the Tables on Probe Pressures—Go With the Flow, Abandon the Scan?
Authors: Matthew M. Fluke
Journal: JAMA (1992)

<h3>To the Editor.</h3> —I wish to call to your attention an error in the article entitled "Diagnosis of Ischemic Stroke" by Dr Caplan published in<i>JAMA</i>.<sup>1</sup> The caption to Fig 2 (p 2417) states "Transcranial Doppler ultrasound images. Pressure, amplitude, and pulsation are damped in the left intracranial vertebral artery compared with the right vertebral artery. Basilar artery<i>pressures</i>are normal [emphasis added]." The transcranial Doppler ultrasound images displayed are graphs of blood flow velocities vs time (as described in the text on p 2416). Pressure data are not displayed. An arterial stenosis severe enough to reduce blood flow velocities would also be expected to reduce arterial blood pressures distal to the lesion. However, one should be aware that, with arterial Doppler studies, one is imaging flow velocity directly, and the status of the pressure can only be inferred.
Pimper Pimped
Authors: Claus A. Pierach
Journal: JAMA (1989)

<h3>To the Editor.—</h3> I hope that Dr Brancati's commentary<sup>1</sup>will not render attending rounds dull by discouraging<i>all</i>"pimping." He gives advice on how not to pimp. Medicine, like good pimping, should stick to the truth. What a bluff: In 1916 Osler was in Oxford and since it was World War I he was not once in the United States that year. Koch could not have asked a single<i>Pümpfrage</i>(much less a series) since there is no such word in German. And Harvey could not have expected his students to know much about circulation in 1628 in London, since<i>De motu cordis</i>was published only that very year (abroad, in Frankfurt am Main).
GENE-07. LIQUID BIOPSY DETECTION OF GENOMIC ALTERATIONS IN PEDIATRIC BRAIN TUMORS FROM CELL-FREE DNA IN PERIPHERAL BLOOD, CSF, AND URINE
Authors: Mélanie Pagès, Denisse Rotem, Gregory Gydush, Sarah Reed, Justin Rhoades, Gavin Ha, Chris Lo, Adam Tracy, Robert Jones, Sarah Becker, Michaela Haller, Susan Chi, Mark Kieran, Liliana Goumnerova, Christopher Love, Keith Ligon, Karen Wright, Viktor Adalsteinsson, Rameen Beroukhim, Pratiti Bandopadhayay
Journal: Neuro-Oncology (2019)

Brain tumors require invasive neurosurgical procedures for diagnosis and tissue acquisition to guide precision medicine. Detection of tumor-derived cell-free DNA (ctDNA) would facilitate tumor profiling without risk of surgery-related morbidity. We aimed to validate a sample collection procedure and develop methodologies to detect ctDNA in CSF, plasma and urine from children with brain tumors. We prospectively collected blood, urine and CSF samples from 268 patients across all histological subtypes. We optimized a method to process ctDNA and performed ultra-low pass whole-genome sequencing (ULP-WGS) on 435 samples from 240 patients, confirming we could reliably construct sequencing libraries. ULP-WGS was used to assess copy number variations (CNVs) and tumor fraction, showing that the majority of samples exhibited no CNV, consistent with either absence in the tumor or low ctDNA level. We developed a pediatric brain tumor hybrid-capture sequencing panel, allowing identification of specific mutations/fusions with 80% sensitivity and 100% specificity at 10,000X depth-sequencing. Comparing sequencing results from ctDNA samples to matched tumors and germline samples confirmed levels of ctDNA that were often too low for informative tumor profiling. The results from this large series provide insights regarding the limits of ctDNA assays to guide clinical care in pediatric brain tumors, across different tumor subtypes.
The Environmental Genome Project: Ethical, Legal, and Social Implications
Authors: Richard R. Sharp, J. Carl Barrett
Journal: Environmental Health Perspectives (2000)

The National Institute of Environmental Health Sciences is supporting a multiyear research initiative examining genetic influences on environmental response. Proponents of this new initiative, known as the Environmental Genome Project, hope that the information learned will improve our understanding of environmentally associated diseases and allow clinicians and public health officials to target disease-prevention strategies to those who are at increased risk. Despite these potential benefits, the project presents several ethical and social challenges. Of immediate concern is the protection of individual research participants. Other ethical issues relate to the application of research results and how study findings could affect social priorities. Clarifying these emerging areas of concern, many of which have not received adequate attention in the existing bioethics literature, is an important step toward minimizing potential research-related risks and defining research needs.
Annual Report of the Supervising Surgeon-General of the Marine-Hospital Service of the United States for the, Fiscal Year 1889.
Journal: JAMA (1890)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Meetings in the United States
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cloud Nine
Authors: None Anonymous
Journal: JAMA (1983)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Antibiotic resistance correlates with use of antibiotics by local practices
Journal: BMJ (1999)

Insulin four times daily is better than twice daily for diabetes in pregnancyDiabetes mellitus complicates about 5% of all pregnan› cies.Good glycaemic control reduces maternal and perinatal morbidity, but there are no data on whether intensifying insulin treatment beyond the conventional twice daily regimen is of benefit.In a randomised con› trolled open label study in nearly 400 diabetic pregnant patients Nachum et al found that a four times daily regimen improved both perinatal outcome and maternal glycaemic control compared with the conventional twice daily regimen (p 1223).The rate of severe maternal hypoglycaemia was, however, similar in both groups.
Confused Chronology
Journal: JAMA (1979)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Acetaminophen (paracetamol) hepatotoxicity with regular intake of alcohol: Analysis of instances of therapeutic misadventure
Authors: H ZIMMERMAN
Journal: Hepatology (1995)

Hepatic injury in alcoholics due to intake of acetaminophen (APAP or acetylparaaminophenol) with therapeutic intent has been reported, but the extent of the phenomenon is not clear, pertinent details of the association remain insufficiently clarified, and the importance of the phenomenon is not widely appreciated. The present report describes 67 patients who developed hepatic injury after ingestion of APAP with therapeutic intent. All were regular users of alcohol. Sixty-four percent of the patients were considered to be “alcoholic” or reported intakes greater than 80 g/d, 35% took 60 g/d or less, and the remainder were vague in their reporting. Doses of APAP were in the “nontoxic” range (<6 g/d) in 60% of the group, within the recommended range (<4 g/d) in 40%, and at 4.1 to 6 g/d in 20%. Characteristic feature was the towering level reached by aspartate transaminase (AST) with figures ranging from 3,000 to 48,000 IU in more than 90% of cases. Almost 20% of the patients died. The data on these patients were similar to 94 cases of injury from APAP taken with therapeutic intent reported in the literature. This study provides further evidence of hepatic injury in regular users of alcohol, especially chronic alcoholics, who take APAP with therapeutic intent. Susceptibility is presumably caused by induction of cytochrome P-4502EI by ethanol and by depletion of glutathione (GSH) because of the effects of alcohol, the malnutrition often associated with alcoholism, and the depletion associated with chronic use of APAP and impaired glucuronidation caused by fasting perhaps as well. The syndrome of liver injury is distinctive, marked by uniquely elevated levels of AST, and poses a significant threat. A greater awareness of the phenomenon by the medical and lay community is essential. (Hepatology 1995;22:767–773.)
American Journal of Medical Sciences, Philadelphia
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CHRONIC ARTHRITIS
Authors: LEONARD W. ELY
Journal: JAMA (1913)

In announcing a series of articles on diseases of bones and joints the editor of one of our medical journals said recently that they would set forth "certain surgical methods quite different from those generally accepted." Therein he was in error, as no "generally accepted" surgical methods exist. The treatment seems largely a matter of temperament and environment. Especially is this true of chronic joint disease, and it will remain true so long as we depend for our inspiration on clinical experience. Clinical experience always has failed us in advancing our knowledge, and it will fail us here. We have still much to learn, but we are picking our way slowly through the tangle. At present chronic arthritis falls to a great extent in the domain of the orthopedic surgeon, but the deeper I go into the subject, the more I am convinced that chronic arthritis must finally be handled
Foreign Letters: London
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Skiing injuries
Authors: A. E. Ellison
Journal: JAMA (1973)

Precisely one decade ago my associates and I wrote in<i>Public Health Reports</i>, "Skiing is one of the most rapidly growing participant sports in the world, and the rising numbers of injured skiers has become a concern both to the medical profession and to the skiing industry itself."<sup>1</sup>Unfortunately, little has changed. Growth has slowed a bit, but even the present rate added far more skiers to the ranks in 1971-1972 than in 1961-1962. Similarly, we can theorize an injury rate of 0.45% this season, and although this is an improvement over the 0.59% of 1961-1962, there is little to rejoice about. The population at risk has roughly doubled—from 2.5 million to 5 million skiers—and the number injured has increased —from approximately 150,000 to 225,000 a year. The only significant change may be in the degree of current "concern" evidenced by the profession, and particularly the industry, toward the
Maintenance Olaparib New Standard in Pancreatic Cancer?
Journal: Cancer Discovery (2019)

In a phase III trial, olaparib maintenance therapy significantly extended progression-free survival and duration of response in patients with BRCA-mutated metastatic pancreatic cancer who responded to platinum-based chemotherapy, compared with a placebo. Based on the findings, which were presented at the 2019 American Society of Clinical Oncology Annual Meeting in Chicago, IL, maintenance olaparib is likely to become a new treatment option for these patients.
Dolutegravir (Tivicay) for HIV
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 13357: Cystatin C Based Estimated Glomerular Filtration Rate (eGFR) Predicts Adverse Clinical Outcomes More Effectively Than Creatinine Based eGFR in Patients With Peripheral Artery Disease
Authors: Otaki Yoichiro, Tetsu Watanabe, Hiroki Takahashi, Gensai Yamaura, Takanori Arimoto, Tetsuro Shishido, Takuya Miyamoto, Isao Kubota
Journal: Circulation (2015)

Introduction: Kidney dysfunction is reported to be associated with adverse outcome in patients with peripheral artery disease (PAD). Estimated glomerular filtration rate (eGFR), which is recently-popularized index for assessing kidney function, is calculated using serum creatinine or cystatin C level. Cystatin C based eGFR (eGFRcys) is less affected by age, gender, and muscle mass compared to creatinine based eGFR (eGFRcr). Hypothesis: We hypothesized that eGFRcys is a feasible prognostic parameter despite muscle sarcopenia in patients with PAD. Methods: We calculated both eGFRcr and eGFRcys according to kidney disease improving global outcomes (KDIGO) guideline in 235 PAD patients who underwent endovascular therapy. Patients were prospectively followed during a median follow up period of 618 days, with the end points of major adverse cardiovascular and cerebrovascular events (MACCE). Results: A multivariate Cox proportional hazard analysis revealed that eGFRcys, but not eGFRcr, was an independent predictor of MACCE. The C index was larger for eGFRcys than eGFRcr (0.70 versus 0.61; P=0.0071). Kaplan-Meier analysis demonstrated that incidence of MACCE was increased with advancing chronic kidney disease stage based on eGFRcys, but not eGFRcr, in patients with PAD. Net reclassification index was improved by addition of eGFRcys to basic predictors. Conclusions: eGFRcys could be a reliable marker for MACCE and risk stratify patients at high risk more effectively than eGFRcr in patients with PAD.
Malaria a Waterborne Disease—An Old Idea.
Authors: J. F. Jenkins
Journal: JAMA (1895)

Tecumseh, Mich., Feb. 9, 1895. <h3>To the Editor:</h3> —Some discussion has lately taken place in theJournaland the<i>Medical Record</i>in reference to malaria being a waterborne disease. That malarial poison is disseminated through the medium of water as well as through the atmosphere is generally mentioned by almost every writer who has given the subject attention. Permit me to quote from a few modern authors: In Reynold's "System of Medicine," Dr. W. C. Maclean states: " That it is a common belief in India that water is capable of absorbing malaria, and that periodic fevers, dysentery, and even cholera are produced by drinking water so charged." Dr. Bristowe states in his work on "Theory and Practice of Medicine:" "That it is dangerous (according to some) to drink the water, however pure it may seem to be, which is furnished by the soil of such localities." Referring to malarious localities,