tbuckley/cabot-search huggingface dataset:
Abstract 496: Block age effect on automated quantitative T cell count using multiplex immunfluorescence
Authors: Igor D. Vidal, Jessica Hicks, Christine Davis, Christopher Heaphy, Angelo Michael De Marzo
Journal: Cancer Research (2019)

Abstract Introduction: Formalin fixation and paraffin embedding is the universal mechanism of tissue preservation. While the data showing detrimental effect on slide storage at room temperature1,2, the evidence supports that paraffin blocks archived at room temperature for as little as two years or as long as 25 years exhibited stable staining for the most of antigens evaluated. 3 Description of experimental procedures: In order to evaluate the effect of block age in inflammatory markers with immunofluorescence, two sets of antibodies were assembled and distributed in two distinct panels of five colors each, using the opal technology based on thyramide signal amplification. The first panel comprised foxp3, p63, CD3, CD4, CK8 and the second, p63, CD3, CD8 and CK8. Both panels were applied to a TMA with samples between sixteen to eighteen years old and compared to one with samples with less than one year old, fixed in FFPE. For each TMA construction, carcinoma prostatic tissue and matched normal prostate not inflamed tissue from forty patients were punched multiple times (between four to six) within regions of interest of each case. The slides were scanned and the image analysis performed. Statistic evaluation was performed using STATA13. The immunofluorescent count was validated using chromogenic CD3 stain controls using separate test TMAs. Unpublished data: The analysis showed an increased number in CD3 positive T-cells in tumor areas, when compared to normal ones. For block age, there was no significant difference between old and new blocks. Conclusion: The number of positive T cells for CD3 comparing new and old blocks of FFPE tissue shows no significant difference. Citation Format: Igor D. Vidal, Jessica Hicks, Christine Davis, Christopher Heaphy, Angelo Michael De Marzo. Block age effect on automated quantitative T cell count using multiplex immunfluorescence [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 496.
The pain of venous cannulation
Authors: S. Dorrell
Journal: Journal of the Royal Society of Medicine (2005)

Erdheim-Chester diseaseDr Lee and his colleagues (April 2005 JRSM 1 ) describe a case of renal failure in which the radiographic appearance of bone pointed to Erdheim-Chester disease, a histiocytosis.Among the organs affected in this condition they mention pericardium.We think it important to emphasize the frequency with which heart, pericardium and great vessels are affected.Recording 6 new patients with cardiovascular involvement, Haroche et al. 2 have reviewed all 178 reported cases of Erdheim-Chester disease.56% had periaortic fibrosis, 44% pericardial infiltration and/or effusions and 31% myocardial infiltration.Interestingly, 6 patients had a right atrial myxoma.Of the 58 patients with follow-up data, 31% died from cardiovascular complications.
MA15.06 Stage I Lung Adenocarcinoma Gene Expression Associated with Aggressive Histologic Features for Guiding Precision Surgery and Therapy
Authors: J. Zhang, E. Burks, T. Sullivan, J. Sands, S. Regis, B. Mckee, A. Mckee, S. Zhang, H. Liu, G. Liu, S. Dubinett, A. Spira, J. Beane, K. Christ, M. Lenburg
Journal: Journal of Thoracic Oncology (2019)
STUDIES OF THE EPIDEMIOLOGY OF STAPHYLOCOCCAL INFECTION
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lorlatinib in NSCLC: Robust Efficacy Seen
Journal: Cancer Discovery (2017)

The investigational ALK inhibitor lorlatinib, whose early clinical activity was first reported last year, continues to look promising in advanced ALK-positive or ROS1-positive non-small cell lung cancer. In a phase II study, robust responses were seen in previously untreated patients, as well as those who had received as many as three prior ALK inhibitors.
Systems Analysis of Adverse Drug Events
Authors: Nancy W. Dickey
Journal: JAMA (1996)

<h3>To the Editor.</h3> —There is no question that the contributions made by Dr Bates and colleagues<sup>1</sup>and Dr Leape and colleagues<sup>2</sup>are important to our knowledge and understanding of adverse drug events. Their research could make a real difference in the health care community's ability to deliver better and safer medical care. However, it is unfortunate that the authors needlessly chose to dramatize their work by making sweeping, scientifically invalid estimates regarding annual rates of iatrogenic injuries and deaths numbering in the millions and hundreds of thousands, respectively. It is simply not scientifically possible to estimate current national iatrogenic injury and death rates based solely on the Harvard Medical Practice Study's (MPS's) decade-old sample of patient discharge records, which included only one state (New York) during just 1 year (1984).<sup>3</sup> We have no desire to minimize the extent or nature of medical injuries, but we are concerned
Commentaire de travail de M. Philipper et al., pp. 300
Journal: Endoscopy (2010)

See also: Prospective comparison of endoscopic ultrasound-guided fine-needle aspiration and surgical histology in upper gastrointestinal submucosal tumorsEndoscopy 2010; 42(04): 300-305DOI: 10.1055/s-0029-1244006
MADRID
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Crack
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Enzyme profiles in the evaluation of pulmonary infarction
Authors: E. L. Coodley
Journal: JAMA (1969)

The diagnosis of pulmonary infarction is dependent upon the use of multiple diagnostic criteria. These include clinical findings, electrocardiographic changes, pulmonary function changes, serial enzyme change, and radiographic techniques. Increased specificity in the diagnosis of pulmonary infarction was found with a profile of enzyme studies including determinations of creatine phosphokinase, serum lactic acid dehydrogenase, and hydroxy butyrate dehydrogenase. The values obtained from a study of this combination of enzymes eliminated patients whose symptomatology simulated pulmonary infarction but actually represented myocardial infarction. The use of isoenzymes was of minimal value in differential diagnosis of this condition.
Selective tyrosine kinase inhibition by imatinib mesylate for the treatment of autoimmune arthritis
Authors: R. T. Paniagua, O. Sharpe, P. P. Ho, S. M. Chan, A. Chang, J. P. Higgins, B. H. Tomooka, F. M. Thomas, J. J. Song, S. B. Goodman, D. M. Lee, M. C. Genovese, P. J. Utz, L. Steinman, W. H. Robinson
Journal: Journal of Clinical Investigation (2006)
Societal views on orphan drugs: cross sectional survey of Norwegians aged 40 to 67
Journal: BMJ (2010)

Objective To determine whether a general societal preference for prioritising treatment of rare diseases over common ones exists and could provide a justification for accepting higher cost effectiveness thresholds for orphan drugs.Design Cross sectional survey using a web based questionnaire.Setting Norway.Participants Random sample of 1547 Norwegians aged 40-67.Main outcome measure Choice between funding treatment for a rare disease versus a common disease and how funds should be allocated if it were not possible to treat all patients, for each of two scenarios: identical treatment costs per patient and higher costs for the rare disease.Respondents rated five statements concerning attitudes to equity on a five point Likert scale (5=completely agree).Results For the equal cost scenario, 11.2% (9.6% to 12.8%) of respondents favoured treating the rare disease, 24.9% (21.7% to 26.0%) the common disease, and 64.9% (62.6% to 67.3%) were indifferent.When the rare disease was four times more costly to treat, the results were, respectively, 7.4% (6.1% to 8.7%), 45.3% (42.8% to 47.8%), and 47.3% (44.8% to 49.8%).Rankings for attitude on a Likert scale indicated strong support for the statements "rare disease patients should have the right to treatment even if more expensive" (mean score 4.5, SD 0.86) and "resources should be used to provide the greatest possible health benefits" (3.9, 1.23).Conclusions Despite strong general support for statements expressing a desire for equal treatment rights for patients with rare diseases, there was little evidence that a societal preference for rarity exists if treatment of patients with rare diseases is at the expense of treatment of those with common diseases.
Melanosis of Esophagus
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Society Proceedings
Journal: JAMA (1929)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction: LSD1 inhibition by tranylcypromine derivatives interferes with GFI1-mediated repression of PU.1 target genes and induces differentiation in AML
Authors: Jessica Barth, Khalil Abou-El-Ardat, Denis Dalic, Nina Kurrle, Anna-Maria Maier, Sebastian Mohr, Judith Schütte, Lothar Vassen, Gabriele Greve, Johannes Schulz-Fincke, Martin Schmitt, Milica Tosic, Eric Metzger, Gesine Bug, Cyrus Khandanpour, Sebastian A. Wagner, Michael Lübbert, Manfred Jung, Hubert Serve, Roland Schüle, Tobias Berg
Journal: Leukemia (2019)
Electron Microscopical Investigation of Asbestos Fibers
Authors: Arthur M. Langer, Anne D. Mackler, Fred D. Pooley
Journal: Environmental Health Perspectives (1974)

Examination of asbestos fibers by electron microscopical techniques enables the observer to distinguish among the fiber types by morphological and structural characteristics.Chrysotile asbestos fibers are composed of bundles of fibrils.Fibers are often curvilinear with splayed ends.Individual fibrils consist of a central capillary defined by an electron dense crystalline wall.With increasing time of electron bombardment, the capillary wail decreases in thickness, deforms, and is encapsulated in an electron translucent material.The change in electron opacity is considered to be a product of structural disruption brought about by dehydroxylation due to electron radiation.A well recognized sequential deformation pattern may be used for identification purposes.Amphibole fibers tend to be straight, splintery, and electron-opaque, although curved fibers are occasionally observed.Diffraction contrast figures are visible as dark bands moving parallel and at right angles to the fiber axis.Crocidolite forms the shortest and thinnest fibers, followed in size by amosite and anthophyllite.Size distribution characteristics of the amphibole fiber types are different.The selected area electron diffraction pattern for chrysotile is unique.Reflections range in forms from streaked to arcuate.Reflection intensity and shape are related to the degree of openness of the fiber bundle and the extent of physical degradation of the fiber.The amphibole asbestos fibers possess diffraction patterns having similar characteristics prohibiting in- dividual identification.Microchemical analysis is required for identification in such cases.A discussion of the industrial hygiene threshold limit values for ampliphibole asbestos fibers is presented.The discussion is based on their differing size distribution characteristics.
Hepatic collagen synthesis and degradation during liver regeneration after partial hepatectomy
Authors: H YAMAMOTO
Journal: Hepatology (1995)

To elucidate hepatic collagen metabolism during liver regeneration after partial hepatectomy, we measured collagen content, collagen synthesis, and collagen-degrading enzyme activity in the remnant livers of rats 3, 5, 7, and 14 days after a partial hepatectomy of 68%. Hepatic collagen synthesis was significantly higher 3, 5, and 7 days after partial hepatectomy than it was in sham-operated control rats, but there was no such difference 14 days after surgery, the maximal hepatic collagen synthesis being observed 5 days after surgery. Although the collagen concentration in the remnant liver was similar to that in the control liver, the total collagen content of the remnant liver increased rapidly with liver increased rapidly with liver regeneration until 7 days after partial hepatectomy. Hepatic collagenase activity was similar to the control; however, hepatic cathepsin B and cathepsin L activity and the intracellular degradation of newly synthesized collagen were markedly decreased 3, 5, and 7 days after partial hepatectomy compared with the controls. Hepatic collagen synthesis was significantly and inversely correlated with cathepsin L activity and with the intracellular degradation of newly synthesized collagen. These findings suggest that a combination of increased collagen synthesis and decreased intracellular collagen degradation contributes to the rapid supply of collagen that is observed during the early phase of liver regeneration. (Hepatology 1995;21:155–161).
A BILL FOR THE REGULATION OF EXPERT TESTIMONY.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Use of Targeted Therapy in the Treatment of Advanced Cutaneous Cancers
Authors: M. Laurin Council
Journal: JAMA Dermatology (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Thymic B‐cell non‐Hodgkin's lymphoma in a child
Authors: Eiichi Azuma, Hidehiro Nishihara, Jiang Qi, Masataka Nagai, Shinya Hiratake, Xiao‐Li Zhang, Yoshihiro Komada, Minoru Hamazaki, Minoru Sakurai
Journal: American Journal of Hematology (1998)

A 13-year-old male developed thymic non-Hodgkin's lymphoma.Microscopically, the tumor was composed of large cells, resembling centroblasts.Immunohistochemically, the tumor demonstrated leukocyte common antigen + , L26 (B-cell) + , UCHL1 (T-cell) -, suggesting the B-cell phenotype.In contrast to the terminally differentiated phenotype (CD10 -, surface immunoglobulin -) observed in adult cases, flow cytometric analysis showed that they were relatively immature: CD10 + , CD19 + , HLA-DR -, IgM +/-, kappa + .He was successfully treated with intensive chemotherapy.Since childhood thymic lymphomas are exclusively small non-cleaved cell lymphoma with T-cell phenotype, this case represents a unique entity in children.Am.
Otolaryngology—Head and Neck Surgery
Authors: Byron J. Bailey
Journal: JAMA (1987)

The exciting new developments in the field of otolarynogology—head and neck surgery can be categorized under three headings: new technology, new applications for recent advances, and refinements in surgical techniques. As we continue to gain experience with innovative diagnostic procedures and operations, they are being employed more appropriately and effectively in the care of patients. Leading this year's parade of progress has been the wider use of the implantable cochlear prosthesis, or cochlear implant. It assists profoundly deaf individuals by providing enhanced sound awareness. While it is not capable of restoring normal hearing ability, it has been found to significantly benefit most individuals in their ability to speech-read (lip-read) in face-to-face conversation. A small group of patients, called "superior listeners," have been able to understand free speech without visual cues after the implant. A number of clinical trials are in progress comparing the models that have a single electrode with