tbuckley/cabot-search huggingface dataset:
Is Preventing Sudden Cardiac Death Realistic?
Authors: Robert J. Myerburg
Journal: Annals of Internal Medicine (1994)

Letters15 May 1994Is Preventing Sudden Cardiac Death Realistic?Robert J. Myerburg, MD, Kenneth M. Kessler, MD, and Agustin Castellanos, MDRobert J. Myerburg, MDUniversity of Miami School of Medicine; Miami, FL 33101Search for more papers by this author, Kenneth M. Kessler, MDUniversity of Miami School of Medicine; Miami, FL 33101Search for more papers by this author, and Agustin Castellanos, MDUniversity of Miami School of Medicine; Miami, FL 33101Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-120-10-199405150-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We appreciate Dr. Sanchez's comments and fully agree that for the general internist practicing in 1994, little can be done to identify risk among persons with no evidence of underlying disease, other than doing standard preventive techniques aimed at decreasing the development of coronary artery disease. After the disease has developed, specific markers are available for at least some of the risk factors associated with sudden death. Multiple strategies will probably be necessary, depending on the size and risk of the targeted population base. The hope for the future is the evolution of simple screening techniques, which could ...References1. Jackman WM, Friday KJ, Anderson JL, Aliot EM, Clark M, Lazzara R. The long Q-T syndrome: a critical review, new clinical observations, and a unifying hypothesis. Prog Cardiovasc Dis. 1988; 32:115-72. Google Scholar2. Nearing BD, Huang AH, Verrier RL. Dynamic tracking of cardiac vulnerability by complex demodulation of the T wave. Science. 1991; 242:437-40. Google Scholar3. Furukawa T, Bassett AL, Furukawa N, Kimura S, Myerburg RJ. The ionic mechanism of reperfusion-induced early afterdepolarizations in feline left ventricular hypertrophy. J Clin Invest. 1993; 91:1521-31. Google Scholar4. Agatston AS, Janowitz WR, Hildner FJ, Zusmer NR, Viamonte M Jr, Detrano R. Quantification of coronary artery calcium using ultrafast computed tomography. J Am Coll Cardiol. 1990; 15:827-32. Google Scholar5. Myerburg RJ, Kessler KM, Castellanos A. Sudden cardiac death: epidemiology, transient risk, and intervention assessment. Ann Intern Med. 1993; 119:1187-97. Google Scholar Author, Article, and Disclosure InformationAffiliations: University of Miami School of Medicine; Miami, FL 33101 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDysrhythmia 15 May 1994Volume 120, Issue 10Page: 891-892KeywordsArrhythmiaFactor analysisForecastingIon channelsIschemiaMagnesiumMedical risk factorsReperfusionStable coronary artery diseaseSudden cardiac death ePublished: 15 August 2000 Issue Published: 15 May 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
<i>The Care of the Insane and Hospital Management</i>. By Charles Whitney Page, M. D., Hartford Retreat, 1871-1888 ; Supt. Conn. Hospital for the Insane, 1898-1901; Supt. Danvers State Hospital, Mass., 1888-1898 and 1903-1910; Member of The American Medico-Psychological Association, The Boston Society of Psychiatry and Neurology, The New England Psychiatric Society and The Mass. Medical Society. (Boston: W. M. Leonard, 1912.)
Authors: H. M. H.
Journal: American Journal of Psychiatry (1912)
The case for reassessment of health care technology. Once is not enough
Authors: H. D. Banta
Journal: JAMA (1990)

Assessment of health care technologies should be an iterative process, not a single event. In the United States there are an increasing number of organized attempts at reassessment of technologies by the health industry, professional societies, and national government agencies, such as the Medical Necessity Project of Blue Cross/Blue Shield, the Clinical Efficacy Assessment Project of the American College of Physicians, and the work of the US Preventive Services Task Force. We examine four clinical practices—electronic fetal monitoring, episiotomy, electroencephalography, and hysterectomy—to illustrate the need to continuously reassess existing technologies and to challenge our current inertia in this critical arena of health practice. (<i>JAMA</i>. 1990;264:235-240)
NON-INVASIVE LUNG IMPEDANCE-GUIDED PREEMPTIVE TREATMENT IN CHRONIC HEART FAILURE PATIENTS: A RANDOMIZED CONTROLLED TRIAL (IMPEDANCE-HF TRIAL)
Authors: Michael Shochat, Avraham Shotan, Ilia Kleiner, Iris Dahan, Mark Kazatsker, Aya Asif, David Blondheim, Yoseph Rozenman, Jean Marc Weinstein, Simcha Meisel
Journal: Journal of the American College of Cardiology (2016)
Schedule dependency of 5-fluorouracil (5FU) chemotherapy in patients with advanced colorectal cancer: A systematic review
Authors: E. Barrajon, G. Esquerdo, A. Lopez, C. Llorca
Journal: Journal of Clinical Oncology (2004)

2139 Background: Clinical schedules of chemotherapy have been based on preclinical biological and animal models. The concept of ‘more is better’ have brought higher response rate with more toxicity in general terms, leading to the concept of ‘maximum tolerated dose’. The pharmacokinetic concept of ‘area under the concentration-time curve’ (AUC) have been tried to summarize the pharmacodynamic concept of ‘dose-response relationship’. Nevertheless, different schedules with the same AUC may produce different patterns of efficacy and toxicity, as is the case for phase-specific agents such as 5FU. The goal of the present study is to apply mathematical models to clinical data on 5FU to explain efficacy and toxicity data which allow the search of optimal schedules. Methods: Clinical trials of 5FU single agent in advanced colorectal cancer have been searched in PubMed extracting data about schedule, response rate and percent of hematological toxicity, mucositis, diarrhea and dermatitis. Data have been analyzed by multivariate regression, as well as pharmacokinetic and cytokinetic analysis. Results: Eighty trials have been identified and included for analysis. Regression analysis shows optimal schedules of 5FU with intermittent doses of 1000–2000 mg/m(2) infused in 12–72 hours. A compartmental pharmacokinetic model points to the ‘time above a threshold’ as the main factor implicated in toxicity. An optimal interval between doses is suggested according to cytokinetic parameters Conclusions: These results should be taken in to account in the design of chemotherapy with multiple drugs and suggest new approaches to the use of the new oral fluoropyrimidines in combination No significant financial relationships to disclose.
Necrotising enterocolitis.
Authors: Peter Bill Juul Ladegaard, Lars Rasmussen, Gitte Zachariassen
Journal: BMJ (1978)

Necrotising enterocolitis (NEC) is a serious complication of prematurity and strikes prematurely in all weight groups. The incidence has been almost unchanged during the latest decades suggesting a limited success with current diagnostic and preventative strategies. Researchers have been looking for novel diagnostic tools to lower the incidence of NEC. Researchers have suggested splitting up NEC in smaller entities to target the preventive strategies, yet no revolutionary tool has been presented. This review is a short overview of the latest knowledge concerning diagnostic strategies.
Incorrect Conversion Factor in Table and Text
Journal: JAMA Cardiology (2017)

Kunal N. Karmali, MD, MS; Donald M. Lloyd-Jones, MD, ScM; Mark A. Berendsen, MLIS; David C. Goff Jr, MD, PhD; Darshak M. Sanghavi, MD; Nina C. Brown, MPH, CHES; Liliya Korenovska, PhD; Mark D. Huffman, MD, MPH
Insulin-like Hypoglycemic Factor Found in the Thymus Reticular Cells
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tumor variation in families with breast cancer
Authors: H. T. Lynch
Journal: JAMA (1972)

This study documents types of malignant neoplasms found in members of 34 families who were selected for investigation because of their having two or more members affected with breast cancer. The data indicate that the members of some families with familial breast cancer have a relatively high predisposition for cancer of the colon, while the members of other families with familial breast cancer show relatively high predispositions, respectively, for gastric, ovarian, and endometrial carcinoma, and some for a complex of brain tumors, sarcoma, and leukemia. The observations are consistent with concepts of multiple causes involving the interactions of different genetic and environmental factors that structure different patterns of tumor association and predisposition.
GIRFT01: Money matters: assessing the value of the adalimumab biosimilar switch plan for dermatology patients
Journal: British Journal of Dermatology (2021)

Despite antibiotics, his condition deteriorated and he developed acute liver failure.He was transferred to the LITU at our centre.Examination revealed an urticated and purpuric papular exanthem with facial oedema and extensive lymphadenopathy.Skin biopsy revealed spongiosis, dermal oedema, perivascular infiltrate, red-cell extravasation and an inflammatory vascular reaction.A diagnosis of trimethoprim-induced DRESS was made.He was given IV methylprednisolone 250 mg on three consecutive days followed by a tapering course of oral prednisolone starting at 30 mg q24h.He was discharged from hospital 10 days after admission; his liver tests settled over the next 3 weeks.Unlike the other severe cutaneous adverse drug reactions, DRESS has a delayed onset following the initiation of the culprit drug, typically between 3 and 8 weeks.The disorder is often mistaken initially for an infective illness.Drug-induced liver injury is the most common systemic feature in DRESS; the mortality in DRESS (approximately 5%) is usually from acute liver failure.Trimethoprim alone is an unusual trigger for DRESS, whereas the sulfa moiety in sulfamethoxazole means that trimethoprim-sulfamethoxazole (Septrin) is a common cause of DRESS.Trimethoprim 300 mg q12h is used as a second-line antibiotic for acne.Based on our experience we would suggest that dermatologists should avoid this drug in the treatment of acne. CPC14Histological and direct immunofluorescence pattern in Schamberg disease: an analytical study
Aerobic Physical Exercise and Atherosclerosis in Men
Authors: Rainer Rauramaa, Timo A. Lakka, Pirjo Halonen
Journal: Annals of Internal Medicine (2004)

Letters7 December 2004Aerobic Physical Exercise and Atherosclerosis in MenRainer Rauramaa, MD, PhD, Timo A. Lakka, MD, PhD, and Pirjo Halonen, MScRainer Rauramaa, MD, PhDFrom Kuopio Research Institute of Exercise Medicine and University of Kuopio, Kuopio, Finland.Search for more papers by this author, Timo A. Lakka, MD, PhDFrom Kuopio Research Institute of Exercise Medicine and University of Kuopio, Kuopio, Finland.Search for more papers by this author, and Pirjo Halonen, MScFrom Kuopio Research Institute of Exercise Medicine and University of Kuopio, Kuopio, Finland.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-141-11-200412070-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Drs. Fennis and Vredeveld suspect that our ultrasound method was incapable of detecting a 0.08-mm difference between the exercise and reference groups. They rely on basic ultrasound physics to justify their concern. They would be correct, if we had dealt only with repeated measurements in a single patient. However, our study was based on several hundred repeated measurements over 6 years in the 2 groups. Statistical analyses were based on the intention-to-treat principle. We know of no evidence for Fennis and Vredeveld's strong statement that “it is commonly accepted that the standard measurement error is 2 to 3 ... Author, Article, and Disclosure InformationAuthors: Rainer Rauramaa, MD, PhD; Timo A. Lakka, MD, PhD; Pirjo Halonen, MScAffiliations: From Kuopio Research Institute of Exercise Medicine and University of Kuopio, Kuopio, Finland. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoEffects of Aerobic Physical Exercise on Inflammation and Atherosclerosis in Men: The DNASCO Study Rainer Rauramaa , Pirjo Halonen , Sari B. Väisänen , Timo A. Lakka , Arno Schmidt-Trucksäss , Aloys Berg , Ilkka M. Penttilä , Tuomo Rankinen , and Claude Bouchard Aerobic Physical Exercise and Atherosclerosis in Men Th. F.M. Fennis and J. W. Vredeveld Metrics 7 December 2004Volume 141, Issue 11Page: 890KeywordsAtherosclerosisDNAExerciseIntent to treat analysisQuality improvementUltrasound imaging ePublished: 7 December 2004 Issue Published: 7 December 2004 Copyright & PermissionsCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Bed Side Effects of The Pill
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Aviation Medicine Experts Concentrate Attention On Pilot Aging, Detection of Incipient Catastrophe
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A profile of 314 Americans graduating form foreign medical schools
Authors: H. R. Mason
Journal: JAMA (1969)

Some students rejected by US medical schools enter foreign medical institutions, but little is known about the quality of their training. Questionnaires were completed by 314 Americans who successfully finished their education in medical schools outside the United States and Canada and received a license to practice in America during 1963-1965. Ninety percent attended medical schools in Europe or Mexico. Forty-five percent earned their degrees after five years of study, while almost the same number took six or more years. Time taken for graduate studies, however, generally equalled that of their contemporaries from American medical schools. Sixty-four percent were board certified or qualified and one-half were engaged in private practice. Seventy-three percent of the group received a passing grade the first time they took the Educational Council for Foreign Medical Graduates (ECFMG) examination; almost all (91%) passed a state licensure test the first try.
专家组为医生提供治疗酒渣鼻的新建议
Authors: M. Schaller, L.M.C. Almeida, A. Bewley, B. Cribier, J. Del Rosso, N.C. Dlova, R.L. Gallo, R.D. Granstein, G. Kautz, M.J. Mannis, G. Micali, H.H. Oon, M. Rajagopalan, M. Steinhoff, E. Tanghetti, D. Thiboutot, P. Troielli, G. Webster, M. Zierhut, E.J. Zuuren, J. Tan
Journal: British Journal of Dermatology (2020)

酒渣鼻是一种主要影响面部皮肤和眼睛的皮肤病。它有许多不同的可见体征和症状,或“特征”。 医生目前正在从一种亚型方法(指定疾病特征分组)转换为一种表型方法,该方法将每个患者看为一个具有其自身特定特征的个体。 2019 ROSCO 小组(专家组)旨在提出建议和制定方法来帮助医生使用表型方法治疗酒渣鼻患者。 专家组由来自世界各地的 19 名皮肤科专家和 2 名眼科专家组成。他们通过流程来投票表达他们对酒渣鼻诊断和管理方面表述的同意程度。有 75% 同意的表述被记录为建议。 专家组建议医生应该在约诊期间与患者讨论疾病负担,并提出问题以帮助他们说明情况。主要治疗目标应该是洁净的皮肤,因为它可以改善患者生活的许多方面。 提供了酒渣鼻如何影响皮肤和眼睛的新描述,以帮助识别这种疾病。最近的研究已被用于更新治疗酒渣鼻的建议,包括联合治疗方法。专家组还开发了酒渣鼻追踪工具,医生可与患者一起使用以持续记录他们的酒渣鼻及其治疗,另外还开发了一个患者病例研究库,以帮助医生识别常见的酒渣鼻特征。 总之,这些建议应该会继续帮助改善酒渣鼻患者的护理。 本摘要涉及研究:酒渣鼻诊断、分类和管理建议:全球酒渣鼻共识 2019 小组(2019 ROSCO 小组)的更新。
Information processing enters medical classroom
Authors: J. W. Zylke
Journal: JAMA (1987)

A MORE unusual requirement soon may join traditional medical school subjects: electronic information use. Dartmouth Medical School, Hanover, NH, is one of a number of schools attempting to teach medical students "computer literacy." The Program in Medical Information Science, directed by J. Robert Beck, MD, attempts to provide students with tools that they can use in all aspects of medical practice, whether to facilitate billing or find the answer to a diagnostic dilemma. Students take a five-hour course in basic computer skills, from using a word processor to searching the literature to creating personal data files. Second-year medical students have been required since 1984 to take a 15-hour course ("Computers and Medical Decision Making") as part of their biostatistics class. Fourth-year students have a number of computer electives from which to choose, including decision analysis, artificial intelligence, and clinical information systems. Courses in basic literature searching and decision making are
Thermocautery causes a gauze pad fire
Authors: D. K. Wood
Journal: JAMA (1993)

<h3>To the Editor.</h3> —We write to alert surgeons of a possible danger from using disposable, battery-powered, hand-held thermocautery units near dry gauze sponges in the operative field. A patient presented to the ambulatory surgery operative suite for excision of a keloid on the right ear. Once the patient was prepared, draped, and given local anesthetic, and the keloid was excised, a hand-held, disposable, battery-operated thermocautery unit was used to provide hemostasis around the skin edge of the operative site. When the cautery was at full temperature, it inadvertently touched a thread of a dry, 4×4 surgical gauze pad that was used to hold back the skin edges. The gauze rapidly was engulfed in flame. It was grasped and thrown to the floor, where the fire was extinguished by stepping on the flame. No injury was sustained by the patient or surgeons. This incident highlights the convenience of and the caution
Error in Author Affiliation
Authors: George Hripcsak, Steven Shea, Martijn Schuemie
Journal: JAMA Internal Medicine (2020)

Messerli et al raised concerns about whether individuals were observed for long enough for differential benefit to emerge.We acknowledge that time at risk is a limitation.We note, however, that our sample size was large, with many patients having longer follow-up times; in the primary analysis, one quarter of patients had more than 1.2 years of follow-up, and in the sensitivity analysis one quarter had more than 1.9 years.Another study using similar methods in the same data sets comparing different classes of antihypertensive drugs 4 found differences in cardiovascular outcomes over the short term, suggesting that the negative finding for benefit for chlorthalidone vs hydrochlorothiazide is not solely due to the time of follow-up.
Prediction of major surgical complications by comprehensive geriatric assessment in elderly patients with gynecologic cancers: A prospective cohort study.
Authors: Jae Weon Kim, Dong-Hoon Suh, Mi-Kyung Kim, Hee-Seung Kim, Hyun Hoon Chung, Noh Hyun Park, Yong Sang Song
Journal: Journal of Clinical Oncology (2013)

e20530 Background: To evaluate the ability of a preoperative comprehensive geriatric assessment (CGA) to predict the risk of postoperative complications in elderly patients who underwent primary surgery for gynecologic cancers. Methods: Sixty consecutive patients (26 ovarian, 16 cervical, 7 endometrial, 5 uterine sarcoma, 4 vulvar, and 2 metastatic cancers) older than 70 years scheduled to take surgery electively for gynecologic cancer were preoperatively assessed by CGA. Every category of CGA was evaluated for in-hospital postoperative complications and mortality within 30 days of surgery. Major complication included any complication of 2 or higher grade according to Memorial Sloan-Kettering Surgical Complication Criteria 12/99. Results: Mean age was 73.6±3.5 years (range 70-85). Overall postoperative complication rate was 30.0% (18/60) including 9 (15.0%) major and 8 (13.3%) multiple complications. Mean hospital stay was 18.4±13.3 days (range 3-81), during which in-hospital mortality was 2 (3.3%). Univariate analysis revealed that dependent instrumental activity of daily living (IADL) was associated with any postoperative complication (p=0.023), especially for multiple complications (p=0.019). However, poor performance status (PS) was associated only with major and multiple complications (p=0.021 and p=0.014, respectively). Multiple regression analysis revealed that dependent IADL was the independent risk factor for any postoperative complication (relative risk [RR] 8.0, 95% confidence interval [CI] 1.1-59.8, p = 0.042). Notably, poor PS was significantly associated with postoperative mortality (p = 0.006), however, dependent IADL with a marginal significance (p = 0.059). Conclusions: IADL and PS were useful to predict postoperative complications and related mortality in elderly patients with gynecologic cancers. Postoperative complications and related mortality can be prevented by identifying the elderly patients with gynecologic cancers who showed dependent IADL and poor PS in CGA.