tbuckley/cabot-search huggingface dataset:
Respiratory epithelial ion transport in patients with disseminated bronchiectasis
Authors: I. Danner, P. Boisseau, E. Chailleux, D. Escande
Journal: European Respiratory Journal (1999)

This study investigated the clinical characteristics and the possible involvement of the cystic fibrosis transmembrane conductance regulator (CFTR) gene in patients with symptomatic diffuse bronchiectasis (DB) associated with rheumatoid arthritis (RA). Twenty-six patients with both RA and DB (group RA+DB) and control groups of 29 consecutive patients with RA but no bronchiectasis (group RA) and 29 patients with symptomatic DB of unknown origin (group DB) were prospectively studied. Among the patients of the RA+DB group, four (15.4%) were heterozygous for the CFTR gene deltaF508 mutation, whereas no deltaF508 mutation was found in patients of the RA and the DB groups (both, p&lt;0.05). This frequency of deltaF508 mutation was also higher than the expected frequency (2.8%) in the general European population (p&lt;0.04). Sweat chloride values and nasal potential differences were normal in three out of four patients carrying the deltaF508 mutation. In the RA+DB group, those with deltaF508 mutation had more frequent chronic sinusitis (p&lt;0.05), a trend toward a more severe pulmonary involvement, and a lower value of nasal potential differences (p&lt;0.01) whereas their rheumatic features had no particularity. In the RA+DB group, patients with adult-onset bronchiectasis (including two with deltaF508 mutation) had a greater reduction in total lung capacity (p&lt;0.05) and lower nasal potential differences (p&lt;0.005) than those with childhood-onset bronchiectasis. This study suggests a possible deleterious effect of the cystic fibrosis transmembrane conductance regulator mutated protein in the airways which may predispose to the development and severity of bronchiectasis in patients suffering from rheumatoid arthritis.
References and Reviews
Journal: JAMA (1972)

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Highlights
Journal: JAMA Psychiatry (2015)

Resting Heart Rate and Violent Criminality 971Low resting heart rate is a well-established correlate of antisocial behavior in children and adolescents.Latvala and coauthors studied resting heart data and records of criminal convictions, assaults, and unintentional injuries in Swedish men.Men with low resting heart rate in late adolescence were at increased risk for violent and nonviolent criminality, being exposed to assault, and unintentional injury in adulthood.In an editorial, Raine discusses the importance of low resting heart rate in violence and antisocial behavior.
PAMPHLETS RECEIVED.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abnormal chest roentgenogram in a patient with hemoptysis
Authors: S. G. Jenkinson
Journal: JAMA (1979)

<h3>History</h3> A previously healthy 49-year-old woman had hemoptysis of one month's duration. She had no chest pain, shortness of breath, or weight loss. She had a history of cigarette smoking for more than 20 years and denied any exposure to tuberculosis or other infectious pulmonary diseases. The patient was afebrile, and examination of the chest disclosed decreased breath sounds in the right upper chest anteriorly. There was no cyanosis or clubbing, and the rest of her physical examination was within normal limits. Routine laboratory data were unremarkable. Figures 1 and 2 are posteroanterior and lateral roentgenograms taken on admission. <h3>Diagnosis</h3> Bronchogenic carcinoma with collapse of the right upper lobe exhibiting the S sign of Golden. <h3>Comment</h3> The posteroanterior chest film (Fig 1) shows the reverse S-shaped curve often seen with collapse of the right upper lobe<sup>1,2</sup>(Fig 3, retouched). The lateral view (Fig 2) confirms the upper lobe collapse.
Accurate and fast estimation of taxonomic profiles from metagenomic shotgun sequences
Authors: Bo Liu, Theodore Gibbons, Mohammad Ghodsi, Todd Treangen, Mihai Pop
Journal: Genome biology (2011)

Deep exome resequencing is a powerful approach for delineating patterns of protein-coding variation among genes, pathways, individuals and populations.We analyzed exome data from 2,440 individuals of European and African ancestry as part of the National Heart, Lung, and Blood Institute's Exome Project, the aim of which is to discover novel genes and mechanisms that contribute to heart, lung and blood disorders.Each exome was sequenced to a mean coverage of 116×, allowing detailed inferences about the population genomic patterns of both common variation and rare coding variation.We identifi ed more than 500,000 single nucleotide variations, the majority of which were novel and rare (76% of variants had a minor allele frequency of less than 0.1%), refl ecting the recent dramatic increase in the size of the human population.The unprecedented magnitude of this dataset allowed us to rigorously characterize the large variation in nucleotide diversity among genes (ranging from 0 to 1.32%), as well as the role of positive and purifying selection in shaping patterns of proteincoding variation and the diff erential signatures of population structure from rare and common variation.This dataset provides a framework for personal genomics and is an important resource that will allow inferences of broad importance to human evolution and health.
Minerva
Authors: S Amerasekera, B Wee, G Jones
Journal: BMJ (2007)

Minerva is always on the lookout for good pictures that are educational and which tell an interesting story accompanied by 100 words.We are more likely to accept a great picture of a relatively common than a very rare or traumatic condition, and we are not interested in pictures of foreign bodies or those that simply show "textbook" presentations.For more information go to http://resources.
CTNI-32. PHASE I/II STUDY OF TEMOZOLOMIDE PLUS NIMUSTINE CHEMOTHERAPY FOR RECURRENT MALIGNANT GLIOMAS: KYOTO NEURO-ONCOLOGY GROUP
Authors: Tomokazu Aoki, Yoshiki Arakawa, Tetsuya Ueba, Masashi Oda, Namiko Nishida, Yukinori Akiyama, Tomokazu Aoki, Koichi Iwasaki, Nobuhiro Mikuni, Susumu Miyamoto
Journal: Neuro-Oncology (2020)

Abstract The objective of this phase I/II study was to examine the efficacy and toxicity profile of temozolomide (TMZ) plus nimustine (ACNU). Patients who had received a standard radiotherapy with one or two previous chemo-regimens were enrolled. In phase I, the maximum-tolerated dose (MTD) by TMZ (150 mg/m2/day) (Day 1–5) plus various doses of ACNU (30, 35, 40, 45 mg/m2/day) (Day 15) per 4 weeks was defined on a standard 3 + 3 design. In phase II, these therapeutic activity and safety of this regimen were evaluated. Forty-nine eligible patients were enrolled. The median age was 50 years-old. Eighty percent had a KPS of 70–100. Histologies were glioblastoma (73%), anaplastic astrocytoma (22%), anaplastic oligodendroglioma (4%). In phase I, 15 patients were treated at four cohorts by TMZ plus ACNU. MTD was TMZ (150 mg/m2) plus ACNU (40 mg/m2). In phase II, 40 patients were treated at the dose of cohort 3 (MTD). Thirty-five percent of patients experienced grade 3 or 4 toxicities, mainly hematologic. The overall response rate was 11% (4/37). Sixty-eight percent (25/37) had stable disease. Twenty-two percent (8/37) showed progression. Progression-free survival (PFS) rates at 6 and 12 months were 24% (95% CI, 12–35%) and 8% (95% CI, 4–15%). Median PFS was 13 months (95% CI, 9.2–17.2 months). Overall survival (OS) at 6 and 12 were 78% (95% CI, 67–89%) and 49% (95% CI, 33–57%). Median OS was 11.8 months (95% CI, 8.2–14.5 months). This phase I/II study showed a moderate toxicity in hematology and may has a promising efficacy in OS, without inferiority in PFS.
A LAW AGAINST “NASTY ADVERTISEMENTS” IN MICHIGAN.
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Developmental Toxicity in the Rat after Ingestion or Gavage of Organophosphate Pesticides (Dipterex, Imidan) during Pregnancy
Authors: R. E. Staples, R. G. Kellam, J. K. Haseman
Journal: Environmental Health Perspectives (1976)

The structural development of fetuses was altered when Dipterex was administered by diet to pregnant rats from days 6 through 15 of gestation. Major external and skeletal alterations occurred after consumption of 432 or 519 mg/kg body weight per day, only minor skeletal changes occurred in the 375 mg/kg dose group and the incidence of alterations in the 145 mg/kg dose group was not significantly different from that in the pair-fed controls. The malformations seen at the two highest doses did not result directly from the associated decrease in food consumed. Dipterex was not shown to have teratogenic potential when given for the same time span, once daily by gavage, even at levels that produced maternal lethality. Imidan was not teratogenic when similarly given, either by diet at concentrations that resulted in a 45% reduction in food consumption, or by gavage at dose levels that resulted in some maternal lethality. Data collected from pair-fed control females revealed that limitation of food consumption to 13--15 g/rat per day from days 6 through 15 of gestation did not result in increased fetal mortality or stunting. However, fetal weight was reduced slightly, and the incidence of minor skeletal changes was approximately three to four times that among fetuses of control dams that were not pair-fed.
Monoclonal and Polyclonal Serum Free Light Chains and Clinical Outcome In Chronic Lymphocytic Leukemia
Authors: Matthew J Maurer, James Cerhan, Jerry A Katzmann, Brian Link, Cristine Allmer, Clive S. Zent, Timothy Call, Kari Rabe, Curtis A. Hanson, Neil E. Kay, Susan Slager, Thomas E. Witzig, Tait Shanafelt
Journal: Blood (2010)
Milk Effect on Mucus Production During Upper Respiratory Tract Infection
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Formula for Calculating the Dosages of Drugs in Emergencies-Reply
Authors: Wesley G. Byerly
Journal: JAMA (1987)

<h3>In Reply.—</h3> We are pleased to note the interest and concerns that have been raised regarding the development of drug administration guidelines for pediatric resuscitation. Our original letter identified two potential problems with the formula published in the American Heart Association (AHA) "Standards and Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiac Care" for the preparation of isoproterenol, epinephrine, and norepinephrine infusions used in pediatric resuscitation.<sup>1</sup>These original concerns regarding the volume of drug needed to prepare the infusions and the number of ampules of drug needed also can be raised with the formula proposed by Dr Chen. As the volume of drug to be added to an intravenous (IV) solution increases, the empty space in the IV container may not be sufficient to hold the additional volume, thereby necessitating the time-consuming process of withdrawing enough fluid from the IV container to allow for the addition of the drug. The
Myocardial perforation by ventriculoatrial-shunt tubing
Authors: A. J. Dzenitis
Journal: JAMA (1965)

CERTAIN well-recognized complications not infrequently follow ventriculoatrial shunts, which are now regarded as the treatment of choice in infantile hydrocephalus.<sup>1-3</sup>Common causes necessitating removal or revision of the shunt are sepsis,<sup>4,5</sup>body growth, and mechanical separation or malfunction of the component parts.<sup>4,6,7</sup>The atrial tubing has been implicated in thromboemboli affecting the pulmonary circulation,<sup>5,6,8</sup>in cardiac arrhythmias,<sup>4</sup>in focal pericarditis, and in endocardial necrosis.<sup>6</sup> This is a report of a unique, well-documented complication of a ventriculoatrial shunt in which the distal silicone-rubber tubing perforated the wall of the right atrium, causing cerebrospinal fluid (CSF) accumulation in the pericardial sac. A similar case was cited by Anderson,<sup>1</sup>who successfully treated the patient with a single pericardial tap, but the etiology was never disclosed. Friedman and co-authors<sup>4</sup>refer to comparable experiences, but clinical information, treatment, eventual outcome, as well as possible mechanisms, are
Massive Myocardial Necrosis with Calcification: Report of Two Cases of Possible Hypokalemic Etiology
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lancet, London
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Evaluation of purine nucleoside phosphorylase release as a measure of hepatic endothelial cell injury*1, *2
Authors: C BRASS
Journal: Hepatology (1995)

With emerging data that endothelial cell (EC) injury is the limiting factor in liver preservation and hepatic function, a simple and reliable biochemical technique for monitoring EC injury is needed. Measurement of purine nucleoside phosphorylase (PNP) release into the circulation from perfused liver has been proposed as such a method. However, our experiments with perfused rat liver did not display a clear or direct relationship between PNP release and endothelial cell injury. Therefore, we re-examined the suitability of using PNP as a measure of nonparenchymal injury by measuring its distribution in purified populations of hepatocytes, ECs, and Kupffer cells (KCs) and correlating cell injury and enzyme release in short-term cultures at 37°C of each cell type. Purified cells were incubated (4 × 106 cells/mL) in oxygen or nitrogen saturated Wisconsin solution or Krebs buffer for 6 hours, with cell viability and PNP release assayed every 2 hours. ECs had the lowest specific activity (27 ± 9 U/ mg protein; mean ± standard error of the mean [Sem]) compared with both hepatocytes (115 ± 15) and KCs (66 ± 18). Despite a decrement in EC and KC viability over time in each incubation solution, there was poor correlation between time of incubation and PNP release (r = .01 to .22), and between cell viability and PNP release (r = .01 to .16). In contrast, PNP release from incubated hepatocytes correlated with the length of incubation (r = .57 to .78) as well as cell injury (r = .63 to .77) in all four test solutions. This data suggest that PNP release is unlikely to specifically reflect EC injury in the intact liver.
The problem of chest "pain". Emphasis on the workup of myocardial ischemia
Authors: J. W. Hurst
Journal: JAMA (1976)

THE ALGORITHM presented here emphasizes the workup of a patient who has chest "pain" whose clinical features might be associated with myocardial ischemia caused by coronary atherosclerosis. Note that the arrows in the algorithm are numbered and correspond to related numbered paragraphs in the discussion. The discussion highlights some of the variables one needs to consider in order to move from one place in the algorithm to another. The physician whose goal is to give comprehensive care should define in advance the items in the history, physical examination, and laboratory workup (which includes a chest roentgenogram and ECG) that should be done on every patient. Items done occasionally are not included in the initial data-gathering process. With this approach, the physician should be able to identify the cause of the chest discomfort in the majority of instances without resorting to additional diagnostic studies. More often than not, the chest pain
Deaths from asthma.
Journal: BMJ (1968)

it should be realized that even if they survive in that situation for only a short time the probability of the transmission of their resistances to human Enterobacteria is still high.To contribute to the transferable resistance factors carried by man, therefore, drug-resistant non-pathogenic E. coli of animal origin need not establish themselves in the human intestine in the same way as salmonellae, which are pathogens, must do in order to cause disease.The example cited in your leading article to support the contention that transferable drug resistance in human bacteria is probably of human origin is misleading.The resistant organisms concerned in the genitourinary tract infections described by Smith and Armour,1 E. coli,