tbuckley/cabot-search huggingface dataset:
KIDNEY'S WATERLOO
Journal: JAMA (1961)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diseases of the Eyes.
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 18323: Complication Rates of Ventricular Tachycardia Ablation: Comparison of Safety Outcomes From Real World to Contemporary Clinical Studies
Authors: Naga Venkata K Pothineni, Abhishek Deshmukh, Deepak Padmanabhan, Swathi Kovelamudi, Siva Mulpuru, Peter A Noseworthy, Hakan Paydak
Journal: Circulation (2015)

Introduction: The availability, national scope and perceived unbiased nature of administrative claims data makes it an attractive choice by health care policy makers for evaluating quality and outcomes. We calculated Ventricular tachycardia (VT) ablation complication rates from national administrative data and compared them with data from randomized trials and prospective studies. Methods: A PUBMED database search was done to identify existing studies of VT ablation. Studies were divided into clinical (randomized controlled trials (RCTs) and prospective studies). Pooled rates of vascular, cardiac, neurological complications and procedure related mortality were computed and compared to reported complication rates from administrative database studies Results: We identified two administrative database studies of VT ablation that included a total of 14,352 procedures and 18 clinical studies with a total of 1,705 procedure. Overall complication rate in administrative studies was higher than in clinical studies (9.39% vs. 7.97%). Rates of cardiac/pericardial (4.47% vs. 2.29%) and vascular access complications (6.9% vs. 3.0%) were higher in real world studies. Neurological complications (1.17% vs. 0.45%) and procedure related mortality (1.53% vs. 1.29%) were higher in clinical studies. Among clinical studies, RCTs had the lowest reported complication rate. Conclusion: Despite substantial improvement, “real-world” complication rates from administrative data remain higher than those reported in RCTs. The discrepancy may be attributable to differences in operator skills, selection bias and variation in data quality. Use of large databases provides an important analytical resource as we embark on improving national health care efficacy and safety in the current challenging environment.
A Course of Lectures on Surgery: Delivered in the Medical School of Cambridge
Authors: G. M. Humphry
Journal: BMJ (1849)

Characters of Pus; Essential and Non-Essential consti- tuents; Process of Suppuration, and Formation of Abscess; Nature of Puts Corpuscles, their Number and Regularity ofShape proportionate to the Activity of the Ilflammation and Vigor of the patient.-Abscesses.may remain stationary, may disappear; Changes in Pus preceding its Absorption; Cases in whichAbsorption most easily occurs; Mode of Advance of Abscesses to the Surface; Reasons for their genemlly Bursting
Leaving cancer diagnosis to the computers
Authors: None The Lancet Digital Health
Journal: The Lancet Digital Health (2020)

Recent reports of artificial intelligence (AI)-based diagnosis of brain cancer, breast cancer, lung cancer, skin cancer, and others profess greater accuracy and faster diagnosis in patients than human specialists, giving prominence to the potential of using deep learning AI tools to improve cancer diagnoses. According to Cancer Research UK, 27·5 million new cancer cases could be diagnosed globally each year by 2040, meaning that radiological imaging data will continue to grow at an inordinate rate when compared with the number of radiologists.
ON THE PATHOLOGY AND TREATMENT OF LARYNGO-TRACHEAL INFLAMMATION
Authors: R. Turner
Journal: BMJ (1854)

sbinoid record of cae consists, in part, of the de- s of o referred to in the preceding communication, A lustative of aious points disusecd therein.It in- des, also, the history of others, believed to possess interest in counexion wish the general subject of La7ngo-TrachealInflammation, especially as regards the question of surgical beatment in dse of this class.CASS L In October of 1844, a boy, a&ed 6, whilst leapt up to gain the latch of a door, drew into his windpip, by the sudden inspiration accompanying this museuar eort,a fragment of an old tobacco-pipe, which he held in
'Normal' CSF in bacterial meningitis
Authors: I. M. Onorato
Journal: JAMA (1980)

Cerebrospinal fluid with a normal cell count, glucose and protein values, and a negative Gram's stain smear is usually assumed to exclude the possibility of meningitis. We describe four patients and review from the literature 19 patients with pyogenic meningitis in whom the CSF initially appeared normal. Thus, finding minimal or no initial CSF abnormality is consistent with early or developing bacterial meningitis. Repeated lumbar puncture and CSF examination within 24 hours should be considered in all febrile patients in whom the clinical features remain compatible with meningitis. (<i>JAMA</i>244:1469-1471, 1980)
Journal of Laryngology and Otology, London
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 2286: Short- and Long-Term Survival of Mitral Valve Repair Versus Mitral Valve Replacement in Patients with Functional Mitral Regurgitation
Authors: Julien Magne, Mario Senechal, Patrick Mathieu, François Dagenais, Jean G Dumesnil, Philippe Pibarot
Journal: Circulation (2008)

Mitral valve repair (MVRp) is associated with better survival in patients with organic mitral regurgitation (MR) when compared to mitral valve replacement (MVR). However, there is an important controversy about the type of surgical treatment that should be used in patients with functional MR (FMR). The aim of this study was to compare MVRp (i.e. restrictive annuloplasty) and MVR in patients with FMR. Pre- and operative demographic and clinical data of 392 patients (64% of male, mean age: 65±10 years) with FMR who underwent mitral surgery between 1992 and 2007 were prospectively collected in a computerized database. MVRp was performed in 52% of patients (n=204) and MVR in 48% (n=188). Compared to patients undergoing MVRp, those with MVR were significantly more frequently symptomatic (77% vs. 59%, p=0.0002), had lower left ventricular ejection fraction (LVEF) (40±15%, vs. 46±15%, p=0.0003) and had higher prevalence of pulmonary hypertension (36% vs. 24%, p=0.01) preoperatively. However, there was no significant difference between the 2 groups with regards to age, gender, MR severity, diabetes, obesity, systemic hypertension and atrial fibrillation (p&gt;0.3). Although operative mortality was significantly lower after MVRp compared to MVR (9% vs. 17%, p=0.02), long-term survival was not statistically different between procedures (6 years: 74±4% vs. 72±4%; 12 years: 54±5% vs. 52±7%; p=0.58). After adjusting for other risk factors, the type of procedure (MVRp vs. MVR) did not come out as an independent predictor of either operative (Odds-ratio=1.7, 95% confidence interval [CI]: 0.8 –3.8, p=0.15) or long-term mortality (Hazard-ratio [HR]=1.1, 95%CI: 0.9 –1.4, p=0.29). The independent predictors of long-term mortality were age (HR= 1.04, 95%CI: 1.01–1.07, p=0.003), NYHA class ≥III (HR=1.4, 95%CI: 1.1–2, p=0.02) and LVEF (HR=1.02, 95%CI: 1.01–1.04, p=0.0009). As opposed to what has been reported in patients with organic MR, there is no evidence that MVRp provides any benefit in terms of survival compared to MVR in patients with FMR. These findings suggest that MVRp is not an optimal surgical treatment for FMR and provide an impetus toward the development of new surgical approaches for these patients.
Scoring Posters at Scientific Meetings: First Impressions Count
Authors: Philip E M Smith, Geraint Fuller, Frank Dunstan
Journal: Journal of the Royal Society of Medicine (2004)

Many specialist societies present "best poster" prizes, yet without generally agreed assessment methods. 31 posters at a neurology meeting were divided randomly into two sets; 14 neurologists, randomized into two groups, were each assigned one poster set. They "quick scored" the first half, viewing posters for 10-15 seconds, and "detailed scored" the others. 11 administrators and pharmaceutical representatives quick scored all posters. Neurologists' quick score ranking correlated highly (r=0.75) with other neurologists' detailed score ranking, and identified four of their six top-ranked posters. Correlations were strongest for presentation (r=0.65), message (r=0.65) and star-quality (r=0.64), but weak for facts (r=0.09), originality (r=0.15) or science (r=0.02). Non-neurologists could not identify the posters ranked highest by neurologists. We conclude that quick ranking by specialists can efficiently identify the best posters for more detailed assessment. On this basis we offer poster-scoring guidelines for use at scientific meetings.
Whole-Genome Epigenomic Analysis in Multiple Myeloma Reveals DNA Hypermethylation of B-Cell Specific Enhancers
Authors: Xabier Agirre, Giancarlo Castellano, Marien Pascual, Simon Health, Marta Kulis, Victor Segura, Anke Bergmann, Anna Esteve, Angelika Merkel, Emanuele Raineri, Lidia Agueda, Julie Blanc, David Richardson, Laura Clarke, Nuria Russiñol, Ana C. Queirós, Renée Beekman, Juan R. Rodriguez-Madoz, Edurne San José-Enériz, Fang Fang, Norma Carmen Gutierrez, José M García-Verdugo, Michael I. Robson, Eric C. Schirmer, Elisabeth Guruceaga, Joost H.A. Martens, Marta Gut, María José Calasanz, Paul Flicek, Reiner Siebert, Elias Campo, Jesus F. San Miguel, Ari M Melnick, Hendrik G. Stunnenberg, Ivo G. Gut, Felipe Prosper, Jose Ignacio Martín-Subero
Journal: Blood (2014)
Cotargeting Androgen Receptor Splice Variants and mTOR Signaling Pathway for the Treatment of Castration-Resistant Prostate Cancer
Authors: Minoru Kato, Carmen A. Banuelos, Yusuke Imamura, Jacky K. Leung, Daniel P. Caley, Jun Wang, Nasrin R. Mawji, Marianne D. Sadar
Journal: Clinical Cancer Research (2015)

Abstract Purpose: The PI3K/Akt/mTOR pathway is activated in most castration-resistant prostate cancers (CRPC). Transcriptionally active androgen receptor (AR) plays a role in the majority of CRPCs. Therefore, cotargeting full-length (FL) AR and PI3K/Akt/mTOR signaling has been proposed as a possible, more effective therapeutic approach for CRPC. However, truncated AR-splice variants (AR-V) that are constitutively active and dominant over FL-AR are associated with tumor progression and resistance mechanisms in CRPC. It is currently unknown how blocking the PI3K/Akt/mTOR pathway impacts prostate cancer driven by AR-Vs. Here, we evaluated the efficacy and mechanism of combination therapy to block mTOR activity together with EPI-002, an AR N-terminal domain (NTD) antagonist that blocks the transcriptional activities of FL-AR and AR-Vs in models of CRPC. Experimental Design: To determine the functional roles of FL-AR, AR-Vs, and PI3K/Akt/mTOR pathways, we employed EPI-002 or enzalutamide and BEZ235 (low dose) or everolimus in human prostate cancer cells that express FL-AR or FL-AR and AR-Vs (LNCaP95). Gene expression and efficacy were examined in vitro and in vivo. Results: EPI-002 had antitumor activity in enzalutamide-resistant LNCaP95 cells that was associated with decreased expression of AR-V target genes (e.g., UBE2C). Inhibition of mTOR provided additional blockade of UBE2C expression. A combination of EPI-002 and BEZ235 decreased the growth of LNCaP95 cells in vitro and in vivo. Conclusions: Cotargeting mTOR and AR-NTD to block transcriptional activities of FL-AR and AR-Vs provided maximum antitumor efficacy in PTEN-null, enzalutamide-resistant CRPC. Clin Cancer Res; 22(11); 2744–54. ©2015 AACR.
Isopropyl Alcohol Intoxication
Authors: Luis Juncos
Journal: JAMA (1968)

Transient acute renal failure, hemolysis, and myopathy occurred during an episode of isopropyl alcohol intoxication. Whether these three phenomena represent a direct toxic effect of isopropyl alcohol ingestion remains a matter of conjecture. Only further observations of other cases of isopropyl alcohol poisoning will establish the significance of the features described. Despite the similarities of intoxication with isopropyl alcohol to that with ethyl alcohol, there are certain clinical features which may be of value in differentiating the two.
THE PAN-AMERICAN MEDICAL CONGRESS.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Book Reviews
Authors: Ronald Grossarth-Maticek, Kjeld Fruensgaard, Henry Nielsen, Anders Hjortshøj, Joan Roberts Field, Harry Olsen, George Lyketsos, Denton C. Buchanan, Gloria J. Waterhouse, Sam C. West, G. Hougardy, D. Luminet, Astrid Nøklebye Heiberg
Journal: Psychotherapy and Psychosomatics (1980)
Family With Hepatitis-Associated Antigen
Authors: William H. Bancroft, Raphael L. Warkel, Anthony A. Talbert, Philip K. Russell
Journal: JAMA (1971)

Hepatitis-associated antigen (HAA) was detected in the serum of a 5 1/2-month-old male infant with giant cell hepatitis. Three of four other members of the family were asymptomatic carriers of HAA with normal or nearly normal results of liver function tests and no history of liver disease. Results of liver biopsies of the carriers were compatible with resolving acute hepatitis in two and chronic hepatitis in one. In these cases, the detection of HAA was a sensitive indicator of the presence of liver disease.
Cases in the Hospital Practice of T. M. Greenhow, Esq., Senior Surgeon to the Newcastle-On-Tyne Infirmary
Authors: C. J. Gibb
Journal: BMJ (1845)

mid-day was 130, almost imperceptible.A tutrpentine stupe was applied, and 4mmonia, with stimulants and brandy, constantly administered, but he never rallied, and gradually sank in the afternoon.'ro the last there was no hiccough nor vomiting.Poet-mortem examination twenty-three hours after death :-Tbe abdomixen very much distended, the whole intestines being filled with a moist fetid gas.The peritoneal zu#fca injected, and nearly universally adherent to those prts of the intestine in contact with it, lymph and pus being effused in several places, and chiey about the folds of the jejunum.The muicous membrane of-this was injected, particularly about its upper third,.increasingtowards the duodenunm, which washiled with a glairy, dark, thick matter, like inspis- sated mucus, and much injected.The stomach was emapty, more vascular than natural, but not inflamed.The liver, spleen, and kidneys were healthy.Head and thorax not examined.A coroner's inquest was held on the body, as this case had made considerable noise in the neighbour- hood, and a verdict of "Died from eating an inordi- nate quantity of mussels" was returned.It is to be remarked that his companion also suffered, but recovered after taking a slight aperient next day.No other cases of similar effects from eating of the same mussels could.Ae traced.Leicester, Nor.20th, 1845.[We cannot record the foregoing case without remarking upon the wretched tampering by unqualified persons with which the first three days of symptomDs, evidently the result of poisoning, were allowed to pass over.Whether., the life of the unfortunate man might have been-saved by judicious medical treatmnent in the.first instance or no, neither lessens-the moral responsibility, nor diminishes the moral guilt, of those who so tecklessly intermeddle with the management of case to which they are utterly incomnpetent; and the
Nephropathy associated with methoxyflurane anesthesia. A follow-up report
Authors: W. B. Crandell
Journal: JAMA (1968)

A toxic nephropathy associated with methoxyflurane anesthesia was observed in 17 patients. Marked diuresis was the predominant clinical characteristic. A test to distinguish between a primary renal disorder and an insufficiency of endogenous antidiuretic hormone was performed on six of the patients. Clear-cut impairment of renal function was demonstrated; gradual improvement, over a period of months, was noted on subsequent studies. Evidence of nephropathy associated with methoxyflurane anesthesia in 28 additional patients has been reported in the literature.
Urinary incontinence.
Authors: M. Briggs, E. S. Williams
Journal: BMJ (1992)

from the area.Moreover, data from Soviet studies met, even when services are available.The reasons The Berlin nosology attempted to establish strict based on much larger samples' or the total popula-for this are not clear, and the issue merits further criteria for diagnosing Marfan's syndrome.'As tion' seem to have been arbitrarily dismissed.One attention.Young comments, skeletal characteristics may be of the most perturbing aspects of the published MARTIN BRIGYGS striking.We have studied families with no such summary is the elimination of the estimates of E S WILLIAMS skeletal features but with aortic dilatation and increased incidences of cancer and leukaemia Department of Public Health Medicine,
AUTHOR'S REPLY
Authors: P. DAVIES
Journal: Thorax (1989)

<h3>Introduction</h3> Approximately 16,000 patients per year are left with a chronic change in bowel function and gastrointestinal symptoms following treatment for cancer. This can have a significant impact upon quality of life and even compromise on-going cancer therapy. Previous small studies focusing mainly on patients with gynaecological cancers suggest that bile acid malabsorption (BAM) may be an important cause of radiotherapy-induced diarrhoea. This retrospective study aims to elucidate the prevalence of BAM in patients referred to a specialist gastroenterology clinic which treats patients with consequences of cancer treatments. <h3>Methods</h3> Patients referred to our clinic are managed using a peer reviewed algorithm. If they report diarrhoea, defined as Bristol Stool Chart type 6–7, a routine referral for a SeHCAT (75-selenium homocholic acid taurine) scan is made to exclude BAM. BAM is diagnosed when the SeHCAT 7 day retention is &lt; 15% and is graded mild (10–15%), moderate (5–10%) and severe (&lt; 5%). <h3>Results</h3> Between 2009–2012, 262 patients were referred for a SeHCAT scan. 139 (53.1%) were male (median age 66, range 32–89) and 123 (46.9%) female (median age 61, range 20–86). 79 (37%) patients had been treated for gynaecological, 94 (44%) for urological, 41 (19%) for anorectal and 30 (11%) for upper gastrointestinal tract cancers. A further 18 (7%) were treated for other cancer types (breast, lung and haematological). BAM was diagnosed in 24 patients (25%) treated for urological cancers, with 17% (n = 4) having severe BAM. 46 patients (58%) treated for gynaecological cancers had BAM, severe in 57% (n = 26). BAM was diagnosed in 22 patients (54%) treated for anorectal cancers, with 55% having severe BAM (n = 12). In 15 patients (50%) treated for upper GI cancers, the majority (73%) had severe BAM (n = 11). For patients with other cancer types, BAM was diagnosed in 8 patients (44%) with severe BAM in 2 of these (25%). <h3>Conclusion</h3> The frequency of severe bile acid malabsorption and its impact on quality of life is poorly appreciated amongst those who treat cancer. BAM is a common problem in patients treated for a wide variety of cancers with a number of different treatment modalities. Given the effectiveness of dietary fat manipulation combined with a new generation of bile acid sequestrants, SeHCAT scanning should be a first line in investigating patients with diarrhoea after cancer therapies. <h3>Disclosure of Interest</h3> None Declared