tbuckley/cabot-search huggingface dataset:
TRAUMATIC ANEURYSM OF THE RIGHT PULMONARY ARTERY
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Renal biopsy
Authors: R. M. Kark
Journal: JAMA (1968)

Percutaneous and surgical renal biopsies are used all over the world for the investigation of patients with renal disorders.<sup>1,2</sup>Although the indications and contraindications for doing the procedure have not changed much over the past few years, technical advances in doing the biopsy and in preparing the tissue for review and conceptual advances in interpreting what is seen<sup>3</sup>have made the procedure easier to do, safer to embark on, and more useful for patient and doctor. While biopsy of the liver is done in most hospitals, renal biopsy is done in relatively few centers. There are two reasons for this. First, the preparation and interpretation of the sections require the skilled attention of pathologists specially trained to deal with renal biopsies and second, and less important, is the fact that it is much more difficult to do a renal biopsy. Considerable training and experience are necessary before the
Severe hypophosphatemia due to hypokalemia
Authors: N. J. Vianna
Journal: JAMA (1971)

Severe hypokalemia, induced by the chronic ingestion of licorice and hydrochlorothiazide, appears to have caused a marked increase in phosphate clearance, a decrease in tubular reabsorption of phosphate, and hypophosphatemia. A decrease in phosphate clearance and a return of the plasma phosphate concentration to normal levels occurred after correction of the potassium deficit.
DNA Adducts of Propylene Oxide and Acrylonitrile Epoxide: Hydrolytic Deamination of 3-Alkyl-dCyd to 3-Alkyl-dUrd
Authors: Jerome J. Solomon, Alvin Segal
Journal: Environmental Health Perspectives (1989)

Propylene oxide (PO) and acrylonitrile epoxide (ANO) are 3-carbon epoxides that are direct-acting mutagens. PO is a rodent carcinogen, and ANO has been postulated to be the ultimate carcinogenic form of acrylonitrile (AN). We have studied the reactions of these agents with 2'-deoxynucleosides and in vitro with calf thymus DNA at pH 7.0 to 7.5 and 37 degrees C. PO was reacted with DNA for 10 hr and resulted in the formation of the following 2-hydroxypropyl (HP) adducts: N6-HP-dAdo (1 nmole/mg DNA), 3-HP-Ade (14 nmole/mg DNA), 7-HP-Gua (133 nmole/mg DNA) and 3-HP-dUrd (13 nmole/mg DNA). 3-HP-dUrd was formed after initial alkylation at N-3 of dCyd followed by conversion of the adjacent exocyclic imino group at C-4 to an oxygen (hydrolytic deamination) with the formation of a dUrd adduct. ANO was reacted for 3 hr with calf thymus DNA and yielded N6-(2-hydroxy-2-carboxyethyl-dAdo (N6-HOCE-dAdo) (2 nmole/mg DNA); 1, N6-etheno-dAdo (11 nmole/mg DNA); 7-(2-oxoethyl)-Gua (7-OXE-Gua) (110 nmole/mg DNA); 3-OXE-dThd (1 nmole/mg DNA); and 3-HOCE-dUrd (80 nmole/mg DNA). As with 3-HP-dUrd, 3-HOCE-dUrd resulted from hydrolytic deamination of an initially formed dCyd adduct. A mechanism is proposed for the conversion of 3-alkyl-dCyd to 3-alkyl-dUrd involving intramolecular catalysis by the OH group on the 3-carbon side chain of the adduct.(ABSTRACT TRUNCATED AT 250 WORDS)
Ankylosing Spondylitis, Hyperuricemia, and Anomalies of the Lumbosacral Junction: A Family Study.
Authors: George R. Thompson
Journal: Annals of Internal Medicine (1964)

s1 February 1964Ankylosing Spondylitis, Hyperuricemia, and Anomalies of the Lumbosacral Junction: A Family Study.George R. Thompson, M.D., Milovan T. Rakic, M.D., William Martel, M.D., John T. Hayes, M.D.George R. Thompson, M.D.Search for more papers by this author, Milovan T. Rakic, M.D.Search for more papers by this author, William Martel, M.D.Search for more papers by this author, John T. Hayes, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-2-315_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt is generally accepted that genetic factors are important in ankylosing spondylitis, hyperuricemia, and gout. While it is probably not a unique association, to our knowledge, there are no reports of these illnesses occurring in the same patient. It therefore seems pertinent to call attention to a family in which hyperuricemia and gout, ankylosing spondylitis, and various developmental anomalies of the lower spine occurred in several members of three generations.The propositus, a 44-year-old man, had tophaceous gout, ankylosing spondylitis, and a transitional lumbosacral vertebra with spine bifida. Of his eight children, two had ankylosing spondylitis, one of whom also... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: George R. Thompson, M.D.; Milovan T. Rakic, M.D.; William Martel, M.D.; John T. Hayes, M.D.Affiliations: Ann Arbor, Michigan PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDie medikamentöse Anregung der Ovulation im doppelten Blindversuch 1 February 1964Volume 60, Issue 2_Part_1Page: 315-315KeywordsAnkylosing spondylitisChildrenGeneticsGoutSpine ePublished: 1 December 2008 Issue Published: 1 February 1964 PDF downloadLoading ...
New Patents
Journal: JAMA (1910)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An Acknowledgement.
Authors: A. Ernest Gallant
Journal: JAMA (1898)

New York, Dec. 25, 1897. <h3>To the Editor:</h3> —Will you allow me to correct an omission and acknowledge my indebtedness to my friend Dr. F. S. Mandlebaum, for the photographs illustrating my article on "Van Arsdale's Triangular Splint for Fracture of the Shaft of the Femur," etc., in your issue of Dec. 18, 1897. Yours fraternally,
Symposium on Calories and Energy Expenditure in Carcinogenesis
Journal: JNCI Journal of the National Cancer Institute (1985)

Symposium on Calories and Energy Expenditure in Carcinogenesis Get access JNCI: Journal of the National Cancer Institute, Volume 75, Issue 6, December 1985, Page 1147, https://doi.org/10.1093/jnci/75.6.1147-c Published: 01 December 1985
Pagetic Pain—A Phonetic Discomfort
Authors: Samuel Vaisrub
Journal: JAMA (1978)

If Sir James Paget were alive today, would he be shocked to see his name transmuted into an eponymic adjective? Would he be appalled to find a reference (<i>Lancet</i>2:213, 1978) to "pagetic pain"? We have no way of knowing, although rumor has it that the sound of a body turning in its grave can on occasion be heard near the cemetery where the renowned English surgeon lies buried. Why, one might ask, should there be shock, even surprise, at the sight of an eponymic adjective? So many of the world's famous and infamous have bequeathed their names for such adjectival use. We engage in socratic dialogue, profess platonic love, entertain napoleonic ambitions, connive in machiavellian intrigues, strike byronic poses, undertake herculean labors, and watch out for freudian slips. As physicians we encounter our own eponymic adjectives—parkinsonian tremor, pavlovian reflexes, pickwickian syndrome—in great profusion. Our exposure to adjectivized eponyms should
What is medical sociology?
Authors: F. A. Ruderman
Journal: JAMA (1981)

AS WE have seen, medical sociology has found some place in medical schools. But clearly, its status there is not high. In medicine's core department, internal medicine, it receives quite a low rating: most responding chairmen consider it unimportant, and many are strongly negative. True, in departments of pediatrics, and still more, in family medicine, its rating is better. Also, one might question the degree to which department chairmen are representative even of their own fields: perhaps age or other variables introduce a bias. But despite whatever questions might legitimately be raised about the results of the study, I believe the picture Petersdorf and Feinstein give us is essentially accurate. It would be a mistake to dismiss the evidence that many, if not most, medical educators—who, after all, have more contact with medical sociology than physicians generally do—have a view of the field that is not particularly flattering. I should
Books received
Authors: Michael Gerber, Irwin Arias, Ted Bader, Sanda Clejan, Robert Heath, Richard Hernandez, R Thomas, Holzbach Yang, Fred Huh, Frank Hunter, Peter Iber, Oscar Kohler, Jonathan Lebwohl, J Leighton, Douglas Lopez, Anastacios Mcgill, Hiroaki Mihas, Fredric Okuda, Donald Regenstein, Vinod Ritt, Fenton Schaffner, Swan Thung, Peter Ward, Jerome Waye, Thomas Whigham, Rowen Zetterman, Raymond Koff
Journal: Hepatology (1990)
Pediatrics, Springfield, Ill
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Retrospect of the Medical Sciences
Journal: BMJ (1843)

A man of the name of Marcille, fifty-three years old, was admitted on the 11th of June, 1841, into the Hotel-Dieu, under M. Roux, for an enormous encepha- loid sarcocele of the right testicle.The disease was only of six months' duration, but it had made such rapid progress as to be as large as a full-sized fcetal head.It was smooth on the surface, not painful on pressure, not transparent, and inconvenient, chiefly on account of its size and weight, rather than from absolute pain.It could be traced as far as the abdo- minal ring by a voluminous pedicle, which was no other than the indurated spermatic chord.The ac- companying general symptoms were broken health, a blueish tint of the skin, loss of appetite, great weak- ness, &c.The tension of the abdomen prevented the discovery of cancerous disease in either the liver or mesentery; the affection of the chord seemed to ter- minate at the abdominal ring-at least it could not be traced further.Roux decided on operating, but anticipated a fatal result:-On making the section of the chord at the ring, he found that the disease extended far into the pelvis.He consequently divided the chord as high up as possible.The patient died four days afterwards of intense peritonitis.The tumor was contained within the tunica albugi- nea, which was of course greatly stretched; it con- sisted in part of cavities containing a blackissh red fluid, and partly of an encephaloid mass undergoing a more or less degree of softening; the chord was af- fected with scirrhus, but at the end nearest the pelvis it again showed the characters of the encephaloid disease.When the body was examined after death, it appeared that the poor wretch was completely the
SUPERFICIAL THROMBOPHLEBITIS
Authors: Irwin D. Stein
Journal: JAMA (1960)

<h3>To the Editor:—</h3> In the Correspondence section ofThe Journal, April 9, page 1679, Dr. Horwitz takes issue with Dr. Kimsey's article, "Treatment of Superficial Phlebitis with Phenylbutazone," published inThe Journal, Jan. 16, page 229. Since 1953 my co-workers and I have had experience in treating about 800 patients with superficial and 150 patients with deep vein phlebitis with phenylbutazone and its analogues (Stein:<i>Angiology</i><b>6</b>:403 [Oct.] 1955;<i>Am. J. Cardiology</i><b>4</b>:476 [Oct.] 1959;<i>Ann. New York Acad. Sci</i>.<b>86</b>:307 [March] 1960). Certain conclusions have been reached which may help reconcile the conflicting views. Every thrombophlebitic process, whether of the superficial or deep veins, is associated with an inflammatory reaction in the walls of the vein, in the perivenous structures, and in the clot itself. By limiting or suppressing the exuberance of this inflammation the physician can reduce greatly the clinical manifestations of discomfort and disability.
Schools of Podiatry Accredited
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Stereotactic radiosurgery for resected brain metastases: Does the surgical corridor need to be treated?
Authors: Siyu Shi, Joseph Abi Jaoude, Navjot Sandhu, Elyn Wang, Kirsten Schofield, Michael C. Jin, Carrie Zhang, Elisa Liu, Erqi L. Pollom, Scott G. Soltys
Journal: Journal of Clinical Oncology (2019)

2068 Background: Post-operative stereotactic radiosurgery (SRS) is the standard of care for resected brain metastases, but SRS techniques are not standardized. Although expert consensus guidelines recommend that the surgical corridor leading to the resection cavity be included in the SRS plan, this statement is not based on data. We analyzed the patterns of failure and toxicity with post-resection SRS, with the hypothesis that the corridor needs not be targeted with SRS. Methods: In this IRB-approved retrospective review, from 428 lesions treated from 2005-2018 with post-resection SRS, 58 lesions (57 patients) had evaluable data and a ‘deep’ tumor with a surgical corridor defined as ≥ 1.0 cm from the surface pre-operatively. SRS targeted the surgical corridor, defined as the surgical tract uninvolved by tumor on pre-operative imaging, in 33(57%). Brain failure was defined as local (LF) if within the surgical cavity involved with tumor pre-resection, corridor (CF) if within the surgical tract leading to the surgical cavity, distant (DF) if a new parenchymal tumor, or leptomeningeal (LMD) for new nodular/classical leptomeningeal enhancement. The cumulative incidences of failure and adverse radiation effect (ARE) were analyzed with death and whole brain radiation therapy as competing risks. Results: The median follow-up was 14 months. Not targeting surgical corridor was associated with prior SRS/resection for other brain metastases (23% vs. 0%, p=0.01), deeper tumors (median 2.1 cm vs. 1.4 cm, p&lt;0.01), and systemic treatment within 3 months (p =0.01), but not other factors (p&gt;0.10). The 12-month failure rates, if surgical corridor was not treated vs. treated, respectively, were: CF 8% (1-24%) vs. 0% (p=0.12), LF 4% (0-17%) vs. 13% (4-27%) (p=0.32), LMD 40% (19-61%) vs. 10% (2-23%) (p=0.03), DF 65% (43-81%) vs. 35% (19-52%) (p=0.02), and ARE 8% (1-22%) vs. 13% (4-28%) (p=0.35). After adjusting for systemic treatment, differences were not statistically significant (p&gt;0.05). Conclusions: Omitting the surgical corridor in post-operative SRS for resected brain metastases was not associated with statistically significant differences in recurrences or adverse radiation effect. Surgical corridor does not need to be included in all post-resection SRS.
Thymosin fraction V and intensive combination chemotherapy. Prolonging the survival of patients with small-cell lung cancer
Authors: M. H. Cohen
Journal: JAMA (1979)

Patients with small-cell bronchogenic carcinoma who received intensive remission-induction chemotherapy randomly received either thymosin fraction V, 60 mg /sq m or 20 mg /sq m twice weekly, or no thymosin treatment during the initial six weeks of chemotherapy. Chemotherapy was then continued for two years. Thymosin administration did not increase the complete response rate. Patients receiving thymosin, 60 mg/sq m, had significantly prolonged survival times relative to the other treatment groups. This benefit was due to prolonged relapse-free survival in complete responders to treatment. The mechanism by which thymosin increased survival duration is unclear but may relate to restoration of immune deficits due to disease or treatment. (<i>JAMA</i>241:1813-1815, 1979)
The continuing failure to understand and treat hypertension
Authors: I. H. Page
Journal: JAMA (1979)

TWO YEARS ago I wrote a philippic regarding the egregious errors involved in measuring blood pressure (BP) and in treating hypertension. Little or nothing has been accomplished by my scolding. Most students of the subject have not seen fit to collect the evidence; consequently, I have no epidemiologic study or comprehensive statistics to prove my point. One useful article written by John Askey, MD, of Los Angeles, elaborating on some of the errors, could not find a publisher; hence, a private printing. I attribute some of the indifference to government and private "educational programs" designed to dispense with any need for professional management or understanding of high BP. In brief, the thesis is that any amateur can measure BP and treat his own hypertension if he has it. Follow the printed directions on the drug package and the disease will soon be under good control. This utter nonsense shows how
A randomized phase II study of individualized stereotactic body radiation therapy (SBRT) versus transarterial chemoembolization (TACE) as a bridge to transplant in hepatocellular carcinoma (HCC).
Authors: Francis Warren Nugent, Krishna Gunturu, Keith E. Stuart, Sebastian Flacke, Chris Molgaard, Klaudia Hunter, Amir Qamar, Shams Iqbal, Frederick Gordon, Kari Galuski, Erin Hartnett
Journal: Journal of Clinical Oncology (2017)

e15677 Background: For HCC pts undergoing LT, local treatment as a "bridge" is standard to decrease likelihood of tumor progression. The most common treatment is TACE, but the safest and most effective bridging modality is unclear. Recently, SBRT has been shown to be both safe and effective when used in pts with locally advanced HCC. We prospectively compare SBRT to TACE as a bridge for HCC pts undergoing LT. Methods: 60 pts are planned for accrual. Pts with C-P &lt; 9 and HCC within Milan Criteria were randomized between two arms. TACE pts received 2 treatments one month apart using DEBDOX beads. TACE pts were hospitalized after each treatment. Pts randomized to SBRT, after fiducial placement, received a median total dose of 45 Gy delivered over 5 fractions. Mean liver dose, Veff, and NTCP were utilized to determine the prescription dose. Pts were assessed by imaging using mRECIST criteria at 2 months and every 3 months thereafter until LT or death. Toxicity and quality of life (QOL) were assessed before treatment, during treatment, 2 weeks post-treatment, and then every 3 months using the PIQ-6 Pain Impact Questionnaire and the SF-36v2 Health Survey. Primary endpoint was need for retreatment of the previously treated lesion(s). Secondary endpoints include toxicity, pathologic response, radiologic response, QOL, and cost. Results: From 9/2014-1/17, 33 pts within Milan Criteria with C-P Class A/B cirrhosis were randomized to TACE (n = 18) vs. SBRT (15). Data on evaluable pts is summarized in the table below. Conclusions: For HCC patients with C-P Class A/B liver cirrhosis, SBRT appears at least equally effective as TACE as a bridge to liver transplantation. SBRT may engender less toxicity, better maintain QOL, and eliminate the need for hospitalization. An update along with a full cost analysis will be presented in June. Clinical trial information: nct02182687. [Table: see text]
445PD ASCEND-6: single-arm, open label, multicenter phase 1/2 study of ceritinib in Chinese pts with advanced ALK-rearranged (ALK+) non-small cell lung cancer (NSCLC) previously treated with crizotinib
Authors: L. Zhang, Y. Shi, D.S.W. Tan, B. Hu, L. Xiaoqing, Y. Cheng, J. Zhou, T. An, Y. Lu, B. Zhu, C. Bai, A. Jappe, V.Q. Passos, Y.Y. Lau, Q. Wang, Y-L. Wu
Journal: Annals of Oncology (2016)