tbuckley/cabot-search huggingface dataset:
Preliminary Results From a Phase I/II Study of Fludarabine, Rituximab, and Lenalidomide In Untreated Patients with Chronic Lymphocytic Leukemia (CLL)
Authors: Ian W. Flinn, Jesus G. Berdeja, Jamie K. Waselenko, R. Seth Cooper, Jia Bi, Kent Shih, Habib H. Doss, Natalie Dickson, Dana S. Thompson, Howard A. Burris, John D. Hainsworth
Journal: Blood (2010)
P10.04 K27M mutation in Histone H3.3 defines a different disease in pediatric and young adult High Grade Gliomas with unique clinical features: the florentine experience with literature review
Authors: M. Lucchesi, S. Scoccianti, M. Guidi, L. Facchini, S. Farina, C. Fonte, C. Favre, L. Genitori, I. Sardi
Journal: Neuro-Oncology (2016)

7 years.Curative surgery was performed in 31 (75,6%) cases.Of these, a macroscopic residual was present in 21 (67,7%) cases.Children aged more than 3 years underwent to radiotherapy in 30 cases (88,2%).About chemotherapy, schemes containing high dose chemotherapy with autologous bone marrow transplant (HDCT) were administered in 11 patients (32,3%).Schemes with exclusive standard dose chemotherapy (SDCT) were administered in 23 patients (67,7%); in particular temozolomide-based schemes (TMZ) were used in 17 cases (73,9%), and platinumbased schemes (CP) in the others 6 (26,1%).In infants (aged less than 3 years), radiotherapy was excluded from primary treatment.These 7 (17%) patients underwent to postoperative chemotherapy with a unique scheme with HDCT.Global progression-free survival (PFS) of primary multimodal treatment was 24,7 months.Global overall survival was 77 months.In univariate analysis infant patients had better OS (not reached versus 38,56 months, p: 0.03).In older than 3 years, there were no significant differences in PFS and in OS for HDCT versus SDCT (p: 0.06) and for CP versus TMZ (p: 0.08).Multivariate analysis confirms the absence of significant differences for any groups (p: 0.51).CONCLUSIONS: historically, HDCT are associated with major toxicities, morbidities, and treatment-related mortality compared to SDCT.Moreover, TMZ are more manageable than CP (no needs of central catheter or prolonged infusions), and this feature is very important in children.If there data will be confirmed in prospective trials, a less aggressive but effective induction treatment would be useful for a better quality of life of these pediatric patients.P10.
The Structural and Functional Basis of Cytokine Receptor Activation: Lessons From the Common β Subunit of the Granulocyte-Macrophage Colony-Stimulating Factor, Interleukin-3 (IL-3), and IL-5 Receptors
Authors: Christopher J. Bagley, Joanna M. Woodcock, Frank C. Stomski, Angel F. Lopez
Journal: Blood (1997)
Physician Manpower and Distribution
Journal: JAMA (1976)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue Access Provided by KOSIN UNIVERSITY MEDICAL LIBRARY JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Contents
Authors: Archibald Garrod, Anna Piro, Antonio Tagarelli, Giuseppe Tagarelli, Paolo Lagonia, Aldo Quattrone, Stephen Winters, Ramana Chennubhatla, Chenxi Wang, James Miller, Laleh Nematollahi, Abbas Kitabchi, Frankie Stentz, Jim Wan, Bagher Larijani, Mohammad Tehrani, Mohammad Gozashti, Kobra Omidfar, Eghbal Taheri, Peter Hager, Johan Permert, Ann-Charlotte Wikström, Margery Herrington, Claes-Göran Östenson, Lisa Strömmer, Masaru Sakurai, Toshinari Takamura, Katsuyuki Miura, Shuichi Kaneko, Hideaki Nakagawa, Parvin Mirmiran, Nazanin Noori, Maryam Zavareh, Fereidoun Azizi, Absalon Gutierrez, Daniela Gonzalez De Serna, Irina Robinson, David Schade
Journal: Metabolism (2009)
The Ukraina Psychoneurological Institute for Five Years (1921-1926).
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Family Practice
Authors: William E. Scheckler
Journal: Annals of Internal Medicine (1978)

III. Comments1 November 1978Family PracticeWilliam E. Scheckler, M.D.William E. Scheckler, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-89-5-863_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptI am probably the only speaker in the Symposium who has a major appointment on a department of family medicine and practice. Infectious diseases are indeed very important in all primary care areas, and that includes family medicine.It is interesting that the federal government has given a large amount of support to development of primary care residency programs and certainly has given a large amount of support to family practice programs. Most of these residencies are university-affiliated, but are located in community hospitals, as are the ones with which I work in Wisconsin (five different residency programs). All of... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Wisconsin Medical School PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1978Volume 89, Issue 5_Part_2Page: 863-864KeywordsInfectious diseasesResidency Issue Published: 1 November 1978 PDF DownloadLoading ...
BELGIUM
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 704: RALB GTPase: A critical regulator of DR5 cell surface expression and TRAIL sensitivity in <i>RAS</i> mutant colorectal cancer
Authors: Hajrah Khawaja, Jamie Z. Roberts, Arman Javadi, Paul O'Reilly, Darragh McArt, Wendy L. Allen, Markus Morrison, Richard Kennedy, Nicolas Vitale, Patrick G. Johnston, Tim Harrison, Daniel B. Longley, Emma Evergren, Sandra Van Schaeybroeck
Journal: Cancer Research (2019)

Abstract RAS mutant (MT) metastatic colorectal cancer (mCRC) remains a difficult-to-treat group. RALA and RALB GTPases function downstream of RAS and have been found to be key regulators of several cell functions and implicated in KRAS-driven tumourigenesis. However, their role as regulators of the apoptotic machinery remains to be elucidated. Here, we found that inhibition of RALB expression, but not RALA, resulted in caspase 8-dependent cell death in KRASMT cells, that was not further increased following MEK1/2 inhibition. Proteomics analysis and mechanistic studies revealed that RALB inhibition induces marked upregulation of the pro-apoptotic cell-surface TRAIL Death Receptor 5 (DR5) receptor in KRASMT CRC. Moreover, DR5 knockout also attenuated siRALB-induced apoptosis, confirming the role of the extrinsic apoptotic pathway as regulator of siRALB-induced cell death. Importantly, TRAIL treatment resulted in acute association of RALB with the death-inducing signalling complex (DISC) and targeting RALB using pharmacologic inhibition or RNAi approaches, resulted in a potent increase in TRAIL-induced cell death in RASMT CRC. Significantly, high RALB mRNA levels were found in the poor prognostic CRIS-B CRC subgroup. Collectively, this study provides the first evidence for a role of RALB in apoptotic priming and that RALB inhibition may be a promising strategy to improve response to TRAIL treatment in poor prognostic RASMT CRC. Citation Format: Hajrah Khawaja, Jamie Z. Roberts, Arman Javadi, Paul O'Reilly, Darragh McArt, Wendy L. Allen, Markus Morrison, Richard Kennedy, Nicolas Vitale, Patrick G. Johnston, Tim Harrison, Daniel B. Longley, Emma Evergren, Sandra Van Schaeybroeck. RALB GTPase: A critical regulator of DR5 cell surface expression and TRAIL sensitivity in RAS mutant colorectal cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 704.
Commentaire de travail de K. de Jong et al., pp. 585
Journal: Endoscopy (2011)

See also: Endoscopic ultrasound-guided fine-needle aspiration of pancreatic cystic lesions provides inadequate material for cytology and laboratory analysis: initial results from a prospective studyEndoscopy 2011; 43(07): 585-590DOI: 10.1055/s-0030-1256440
Utility of Specific Locus Systems in Higher Plants to Monitor for Mutagens
Authors: Milton J. Constantin
Journal: Environmental Health Perspectives (1978)

Plants possess biological and operational attributes that have encouraged geneticists to use them extensively in the development of fundamental genetic concepts. Attributes such as regenerative plasticity, high fecundity, cultural adaptability, range of ploidy, economics of culture and maintenance of specific populations, and versatility make plant genetic systems prime candidates with which to monitor the environment for mutagens. A specific locus (equivalent to a classical Mendelian gene) controls the development of a phenotypic characteristic. It can also mutate to a new allelic form with a consequentially altered phenotypic characteristic and can be separated by crossing over from adjacent loci that govern other specific phenotypic characteristics. Since various plant species have numerous specific loci, one has a rich array of potential systems from which to select. Specific locus systems in higher plants could be used to assess the mutagenicity of single chemical compounds or combinations of chemical compounds. Depending on the circumstances, seeds and/or seedlings could be used; plants could be grown in situ in either containers or plots to assess the immediate environment for one or more mutagens over an extended period. Since plants are eucaryotes, data from such experiments could serve as one more source of information along with that obtained from a battery of other tests used in the tier system.
Fetal and infant mortality in Norway and the United States
Authors: J. D. Erickson
Journal: JAMA (1982)

Relative to the countries of northern Europe, the United States has a high crude infant mortality rate. We compared the United States' fetal and infant mortality rates with those of Norway, a nation that is internationally recognized for having a low infant mortality. Norwegian birth-weight-specific rates were applied to the US birth populations, yielding adjusted rates. The adjusted rates, which are the crude rates that would have resulted in the United States if the Norwegian birth-weight-specific rates had been in force, were generally higher than the US rates that were actually observed. Thus, the major reason for the United States' poor international rank is probably its unfavorable birth-weight distributions, and any major improvement in the United States' international standing will likely await a reduction in the proportion of high-risk, low-weight births. (<i>JAMA</i>1982;247:987-991)
Folic acid paradoxes: 1 to 2 mg folic acid plus B6 and B12 worsens psoriasis and 5 to 7 mg daily folic acid plus B6 and B12 alone may improve psoriasis, but adding 5 mg folic acid plus B6 and B12 to adalimumab cannot in general be recommended
Journal: Journal of the American Academy of Dermatology (2014)
Calcified Liver Metastases: A Specific Roentgen Diagnostic Sign
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reply
Authors: Meghan I. Dubina, Jennifer C. Sri, Stephen K. Tyring, Anthony A. Gaspari
Journal: Journal of the American Academy of Dermatology (2012)

of the Journal of the American Academy of Dermatology; generalized verrucosis (GV) is indeed an interesting, yet underreported topic, even in major textbooks.I was surprised by the fact systemic retinoids were briefly stated to be effective but not treated in depth, in spite of the fact etretinate has been used in this setting since the 1980s. 2,3 In the period 1991 through 2009, I observed and treated 5 patients (1 male, 4 female; aged from 16-39 years) with GV using retinoids (3 with etretinate, 2 with acitretin; at standard dosages).In all patients warts had been present and growing for years, and diagnosis had been confirmed on histologic examination.No evident immunologic abnormality could be detected with standard investigations (leukocyte count, serum immunoglobulin concentrations, lymphocyte subpopulations) in 4 of them.Indeed, patients with GV do not necessarily have overt immune dysfunction, 4 either common or exotic onesea point overlooked in the review. 1 Only 1 case was HIV-related, and this woman requested additional palmar photodynamic therapy.Her disseminated warts were unresponsive to highly active antiretroviral therapy.Conversely, oral retinoids yielded good results, with rapid (\1 month) disappearance of warty lesions, which typically recurred within 6 months after the aromatic retinoid was suspended.An exception was the male patient, who enjoyed an inexplicable sustained remission up to 3 years before being lost to follow-up.The drawbacks of this therapeutic choice are self-evident (women in childbearing age; side effects of prolonged retinoid administration), but not different from those ensuing from chronic retinoid administration for more usual conditions.In my opinion, intralesional interferon, topical imiquimod, cidofovir, or bleomycin, albeit different and highly sophisticated in their mechanisms of action, 1 are comparable to plain surgical destructive techniques as to their effectiveness.Two patients had tried oral cimetidine, which proved ineffective.Sri et al 1 speak of few randomized controlled trials exploring the optimal treatment for both GV and localized warts. 1 I am not aware of the existence of such studies.The condition is too rare to hope randomized controlled trials will ever be available.GV was recognized as a distinct entity in 1956. 5 Since then, fewer than 30 cases have been reported.I point out that the paradigm of clinical case reporting in evidence-based medicine 6 fully applies to such rare patients.Accordingly, I would like to share this ''n-of-5'' observational series of GV satisfactorily treated with systemic retinoids with the dermatologic community.
Legislation
Authors: Clement Martin
Journal: JAMA (1963)

<h3>To the Editor:</h3> —In the Dec 15 issue ofThe Journal(<b>182</b>:1094-1098) there appeared an article which contained certain suggestions in an area about which the medical profession does not seem to know what its respective hands are doing. The article, "Experimental Study on Effect of Cigarette Smoke Condensate on Bronchial Mucosa," included the sentence on p 1097: "We believe that the evidence is sufficient to warrant preventive measures. These preventive measures should include an intensive educational program and legislation against advertising..." I have heard recently, also, physicians make comments about public consumption, in which area they desire legislation for the use of safety belts. I know that many of these same physicians, and certainly the majority of us, do not wish legislation for medical practice. How do we justify our attempts to force legislation on others when we wish to remain free of legislation? If we want to
Journals, clinicians, and medical trends
Authors: A. Soffer
Journal: JAMA (1977)

Medical journals have recently been criticized for publishing misleading and impractical data. One clinician decries the publication of studies that are refuted by later reports.<sup>1</sup>He labels these practices "controversial" and concludes that a medical journal should publish only material that has been "completely researched, documented and approved." Another clinician insists that periodicals that publish clinical investigations are not appropriate for "working doctors," and he asserts that a clinician's journal should consist exclusively of articles containing practical information that has been "tested and approved."<sup>2</sup> Implicit in the frustration of these physicians is the belief that clinical trials must provide clearly defined conclusions that offer irrefutable clinical guidelines. Unfortunately, the foolproof clinical trial does not exist. Formulation of medical concepts is an ongoing process, and publication of even the most carefully structured clinical experiment is but one step in the historic development of new principles. We must leave to
Abstract 11478: Excellent Clinical Courses of Autologous Skeletal Myoblast Sheet Transplantation Compared to a Propensity Score-Matched Cardiac Resynchronization Therapy <i>(Best of Basic Science Abstract)</i>
Authors: Teruhiko Imamura, Koichiro Kinugawa, Yasushi Sakata, Shigeru Miyagawa, Yoshiki Sawa, Kenji Yamazaki, Minoru Ono
Journal: Circulation (2015)

Introduction: We recently reported a multi-center, single-arm, phase II study that evaluated the efficacy and safety of autologous skeletal myoblast sheet (TCD-51073) transplantation. The advantage of this procedure over a control group has not yet been analyzed. Hypothesis: TCD-51073 has better clinical outcome compared with background-matched control group. Methods: Seven patients with advanced heart failure due to ischemic etiology (TCD-51073 group, New York Heart Association [NYHA] class III; left ventricular ejection fraction (LVEF) &lt;35%) refractory to optimal medical and coronary revascularization therapy, received TCD-51073 at 3 study centers between 2012 and 2013 with a 2-year follow-up period. As previously reported, 112 patients received cardiac resynchronization therapy (CRT) with follow-up at the University of Tokyo Hospital between 2007 and 2014. Results: Of them, 21 patients were selected for the control group by propensity score matching. No significant difference in baseline variables between the groups was observed. LVEF and NYHA class improved significantly in the TCD-51073 group during the 6-month study period (p&lt;0.05). During the 2-year follow-up, 7 patients (33%) in the CRT group and no patient in the TCD-51073 group died due to cardiac disease or received VAD implantation (p=0.128 by the log-rank test). Conclusions: Transplantation of TCD-51073 is clinically advantageous in facilitating LV reverse remodeling, improving HF symptoms, and preventing cardiac death in patients with ischemic etiology when compared to background-matched patients receiving CRT.
Measurement of Some Potentially Hazardous Materials in the Atmosphere of Rubber Factories
Authors: Arnold Nutt
Journal: Environmental Health Perspectives (1976)

Two separate topics of work are outlined: methods for the measurement of chlorinated monomers in PVC and polychloroprene, and also methods for the measurement of these materials in factory air. Typical results which have been obtained in supplies of raw materials, in finished products, and in the working atmosphere at manufacturing operations are given. The second topic concerns the measurement of benzo[a]pyrene in the atmosphere of a tire manufacturing plant. This material is present in trace quantities in the mineral oils and carbon blacks used by the industry. The atmospheric concentrations present at various processes in this plant were measured on a daily basis over a period of two years, and the results obtained compared with results taken concurrently from an outside air station. It is shown that no significant quantities of benzo[a]pyrene are produced by tire manufacturing operations.