The CKD-EPI Equation and MDRD Study Equation Find Similar Prevalence of Chronic Kidney Disease in Asian Populations
Authors: Andrew S. Levey
Journal: Annals of Internal Medicine (2009)

Letters15 December 2009The CKD-EPI Equation and MDRD Study Equation Find Similar Prevalence of Chronic Kidney Disease in Asian PopulationsAndrew S. Levey, MD, Lesley A. Stevens, MD, MS, and Josef Coresh, MD, PhDAndrew S. Levey, MDFrom Tufts Medical Center, Boston, MA 02111; and Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205.Search for more papers by this author, Lesley A. Stevens, MD, MSFrom Tufts Medical Center, Boston, MA 02111; and Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205.Search for more papers by this author, and Josef Coresh, MD, PhDFrom Tufts Medical Center, Boston, MA 02111; and Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-151-12-200912150-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Dr. Sabanayagam and colleagues report that mean estimated GFR when computed with the CKD-EPI equation is higher than with the MDRD Study equation in a young Asian sample (presumably with high GFR) of mixed ethnicity. This confirms our findings in a predominantly U.S. and European sample and is expected because of the form and coefficients for the variables for both equations. Studies with measured GFR must evaluate the accuracy of GFR estimates in Asian persons. The CKD-EPI equation has no “Asian coefficient,” so we suspect that it will not be as accurate in Asian persons as in our ...References1. Matsuo S, Imai E, Horio M, Yasuda Y, Tomita K, Nitta K, et al; Collaborators developing the Japanese equation for estimated GFR. Revised equations for estimated GFR from serum creatinine in Japan. Am J Kidney Dis. 2009;53:982-92. [PMID: 19339088] CrossrefMedlineGoogle Scholar2. Rule AD, Teo BW. GFR estimation in Japan and China: what accounts for the difference? [Editorial]. Am J Kidney Dis. 2009;53:932-5. [PMID: 19463761] CrossrefMedlineGoogle Scholar3. Stevens LA, Coresh J, Greene T, Levey AS. Assessing kidney function—measured and estimated glomerular filtration rate. N Engl J Med. 2006;354:2473-83. [PMID: 16760447] CrossrefMedlineGoogle Scholar4. Coresh J, Selvin E, Stevens LA, Manzi J, Kusek JW, Eggers P, et al. Prevalence of chronic kidney disease in the United States. JAMA. 2007;298:2038-47. [PMID: 17986697] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Tufts Medical Center, Boston, MA 02111; and Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoA New Equation to Estimate Glomerular Filtration Rate Andrew S. Levey , Lesley A. Stevens , Christopher H. Schmid , Yaping (Lucy) Zhang , Alejandro F. Castro III , Harold I. Feldman , John W. Kusek , Paul Eggers , Frederick Van Lente , Tom Greene , Josef Coresh , and The CKD-EPI Equation and MDRD Study Equation Find Similar Prevalence of Chronic Kidney Disease in Asian Populations Charumathi Sabanayagam , Tien Y. Wong , and E. Shyong Tai Metrics 15 December 2009Volume 151, Issue 12Page: 893KeywordsChronic kidney diseaseConflicts of interestCreatinineDietForecastingKidneysMicroalbuminuriaMusclesPopulation statistics ePublished: 15 December 2009 Issue Published: 15 December 2009 CopyrightCopyright © 2009 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...