tbuckley/cabot-search huggingface dataset:
Abstract 102: Midkine, A New Functional Cytokine, Increased After IVIG May Protects From Vascular Injury In Acute Kawasaki Disease
Authors: Ben T Saji, Shinichi Takatsuki, Yasushi Kenmotsu, Kazuyuki Naoi, Satoshi Ikehara, Tomotaka Nakayama, Hiroyuki Matsuura, Natsuko Kusunoki, Shinichi Kawai
Journal: Circulation (2015)

Introduction: Midkine(MDK), found in 1988, a heparin-binding low-molecular protein, is a member of growth factors or cytokines, activated in the process of inflammatory disorders like RA, cancer development, angiogenesis and wound healing etc. It also acts as protecting cell apoptosis, stimulating fibrinolysis on endothelial cells, inhibiting or suppressing the development of regulatory T cells, improving myocardial dysfunction, and promoting the survival of ischemic myocardium. But, little is known in vasculitis syndrome. Methods: Serum samples, clinical data and laboratory values from17 patients with acute KD patients in before, 1-2 days, and 7-10 days after IVIG. Serum samples were analysed for MDK concentrations by EIA with anti-human MDK antibody. Results: MDK values were significantly elevated in serum from 1-2d after IVIG; 1-2d after IVIG; mean=1291.6 ± 1119.0, compared with Pre-IVIG; mean=530.9±468.6(p&lt;0.01), and rapidly decreased 7-10d after IVIG; mean=599.4±447.3 pg/ml(p&lt;0.05)(healthy human cut off level; &lt; 300pg/ml). CRP is significantly correlated with MDK (r=0.45, p&lt;0.05). MDK of 2 patient with CAA was higher than that of no CAA. Discussions and Conclusions: Knockout mice deficient in the MDK gene poorly develop neointima when the artery is damaged by ischemic shock. Clinically, MDK increases in human carcinoma and play a central role in inflammatory pathway. It promotes the migration of inflammatory leucocytes, namely macrophages and neutrophils. Recently, it is becoming a molecular target for the treatment or prevention of inflammatory diseases. Finally, this preliminary study suggests that MDK is a possible novel effector and may be relevant in the pathogenesis of arteritis in acute KD. IVIG may increase MDK levels and protect from inflammatory vascular damage.
Lead poisoning among low-income children in Orange County, California. A need for regionally differentiated policy
Authors: G. A. Gellert
Journal: JAMA (1993)

<h3>Objective.</h3> —To estimate the prevalence of elevated lead levels among children in Orange County, California, and to evaluate the appropriateness of a universal pediatric blood lead screening policy in this community. <h3>Design.</h3> —Venous blood lead testing was conducted and results were analyzed according to seven blood lead strata ranging from less than 0.50 μmol/L (10 μg/ dL) to 3.35 μmol/L (70 μg/dL) or higher. A cost analysis of the lead-testing program in Orange County was conducted. <h3>Setting.</h3> —Children meeting poverty eligibility criteria and attending the Child Health and Disability Prevention Program, the state's implementation of the federal Early and Periodic Screening, Diagnosis and Treatment (EPSDT) services program. <h3>Participants.</h3> —A total of 5115 Orange County children between 12 and 72 months of age using EPSDT services from March through December 1992. <h3>Main Outcome Measures.</h3> —Blood lead levels and associated costs of the testing program stratified by level of blood lead elevation. <h3>Results.</h3> —Blood lead levels of 0.50 μmol/L (10 μg/dL or higher were found in 371 children (7.25%; 95% confidence interval, 6.66% to 7.85%), but only six children (0.12%; 95% confidence interval, 0.04% to 0.20%) had elevations greater than 1.20 μmol/L (25 μg/dL). Five children (83.3%) had histories of lead consumption unrelated to ingestion of lead-containing paint but related to the use of lead-containing folk remedies and cooking utensils. Costs for detection of children with blood levels elevated to 0.50 μmol/L (10 μg/dL) or higher was $310 per child and for levels of 1.20 μmol/L (25 μg/dL) or higher was $19139 per child. <h3>Conclusions.</h3> —These data suggest that lead poisoning is not a major public health problem among Orange County children and detection of infrequent cases would involve a high cost per child. In jurisdictions with newer housing, initial screening for a history of possible lead exposure alone may offer reasonable efficacy that is cost-effective. The scope of lead-testing programs should be determined according to local needs and conditions. (<i>JAMA</i>. 1993;270:69-71)
Eosinophilic granuloma of the gastrointestinal tract
Authors: C. S. Pitchumoni
Journal: JAMA (1970)

Eosinophilic granuloma of the gastrointestinal tract is a rare disease which may involve the gastrointestinal tract diffusely or as localized polyps. The diffuse form of the disease may be diagnosed by peroral small-bowel biospy. The clinical features mimic many conditions which require surgery, and the diagnosis can only be made histologically. When laparotomy is not urgently required, surgical exploration may be avoided by the use of peroral biopsy to make the diagnosis.
AUTHOR'S REPLY
Authors: C. Skinner
Journal: Thorax (1995)

<h3>Abstract</h3> Dendritic geometry is largely determined during postnatal development and has a substantial impact on neural function. In sensory processing, postnatal development of the dendritic tree is affected by two dominant circuit motifs, ascending sensory feedforward inputs and descending and local recurrent connections. In the three-layered anterior piriform cortex, neurons in the sublayers 2a and 2b display vertical segregation of these two circuit motifs. Here, we combined electrophysiology, detailed morphometry and Ca<sup>2+</sup> imaging in acute mouse brain slices and modeling to study circuit specific aspects of dendritic development. We observed that determination of branching complexity, dendritic length increases and pruning occurred in distinct developmental phases. Layer 2a and layer 2b neurons displayed developmental phase specific differences between their apical and basal dendritic trees related to differences in circuit incorporation. We further identified functional candidate mechanisms for circuit-specific differences in postnatal dendritic growth in sublayers 2a and 2b at the meso- and microscale level. Already in the first postnatal week, functional connectivity of layer 2a and layer 2b neurons during early spontaneous network activity scales with differences in basal dendritic growth. During the early critical period of sensory plasticity in the piriform cortex, our data is consistent with a model that proposes a role for dendritic NMDA-spikes in selecting branches for survival during developmental pruning in apical dendrites. The different stages of the morphological and functional developmental pattern differences between layer 2a and layer 2b neurons demonstrate the complex interplay between dendritic development and circuit specificity. <h3>Significance Statement</h3> Sensory cortices are composed of ascending sensory circuits that relay sensory information from the periphery and recurrent intracortical circuits. Dendritic trees of neurons are shaped during development and determine which circuits contribute to the neuronal input space. To date, circuit-specific aspects of dendritic development and the underlying mechanisms are poorly understood. Here, we investigate dendritic development in layer 2 of the piriform cortex, a three-layered palaeocortex that displays a clear vertical segregation of sensory and recurrent circuits. Our results suggest that dendritic development occurs in distinct developmental phases with different circuit-specific properties. We further identify candidate mechanisms for neuronal activity patterns that could determine differences in circuit-specific dendritic development.
The triplet vinorelbine (NVB), ifosfamide (IFO) and cisplatin (CDDP) (NIP) used as post-operative treatment versus surgery alone in patients having received primary chemotherapy (CT) for locally advanced (LA) non small cell lung cancer (NSCLC)
Authors: D. Grunenwald, G. Ziolo, H. Olechnowicz, J. Dahabreh, F. Carpagnano, S. Leong, A. Fittipaldo, C. De Almeida, D. Aubert, M. Gottfried
Journal: Journal of Clinical Oncology (2004)

7172
PDTM-48. PEROXIREDOXIN1 IS A THERAPEUTIC TARGET IN GROUP-3 MEDULLOBLASTOMA
Authors: Sajesh Babu, Refaat Omar, Holly Fediuk, Lin Li, Ludivine Coudiere-Morrision, W Wang, J Pu, H D Sun, Tamra Werbowetski-Ogilvie, Matthias Wölfl, Marc Remke, Michael Taylor, Charles Eberhart, Marc Symons, Rosamaria Ruggieri, Magimairajan Issai Vanan
Journal: Neuro-Oncology (2017)

Group-3 medulloblastoma (MBL), one of the most common malignant pediatric brain tumors, is highly resistant to radiation and chemotherapy and have the worst prognosis. Hence, there is an urgent need to elucidate targets that can sensitize these tumors to conventional chemotherapy and radiation. We identified PRDX1 as therapeutic candidate in Group-3 MBL. Inhibition of PRDX1 using Adenanthin or RNAi led to radiation sensitization in D425-med cells when compared to controls. Over expression of PRDX1 in SHH- group (Daoy cells) resulted in radiation resistance. Targeting PRDX1 resulted in extensive oxidative DNA damage and induction of apoptosis. Nude mice with Group-3 MBL flank tumors when treated with Adenanthin had significant decrease in tumor volume and survived longer. Mice bearing orthotopic tumors from patient derived xenografts / Group-3 MBL cells with diminished PRDX1 expression or PRDX1 inhibition by Adenanthin survived longer when compared to controls. We also correlated PRDX1 expression to patient outcomes in a validated Medulloblastoma tumor microarray (TMA). We performed next generation whole genome sequencing to identify pathways that are affected with PRDX1 inhibition or silencing. The results from these experiments will be presented. Our results suggest that PRDX1 is a therapeutic target in all sub-groups of medulloblastoma and Adenanthin could be used as a radio-sensitizer in the treatment of Group-3 MBLs.
Particulate Air Pollution and Respiratory Disease in Anchorage, Alaska
Authors: Mary Ellen Gordian, Haluk Ozkaynak, Jianping Xue, Stephen S. Morris, John D. Spengler
Journal: Environmental Health Perspectives (1996)

This paper examines the associations between average daily particulate matter less than 10 microns in diameter (PM10) and temperature with daily outpatient visits for respiratory disease including asthma, bronchitis, and upper respiratory illness in Anchorage, Alaska, where there are few industrial sources of air pollution. In Anchorage, PM10 is composed primarily of earth crustal material and volcanic ash. Carbon monoxide is measured only during the winter months. The number of outpatients visits for respiratory diagnoses during the period 1 May 1992 to 1 March 1994 were derived from medical insurance claims for state and municipal employees and their dependents covered by Aetna insurance. The data were filtered to reduce seasonal trends and serial autocorrelation and adjusted for day of the week. The results show that an increase of 10 micrograms/m3 in PM10 resulted in a 3-6% increase in visits for asthma and a 1-3% increase in visits for upper respiratory diseases. Winter CO concentrations were significantly associated with bronchitis and upper respiratory illness, but not with asthma. Winter CO was highly correlated with automobile exhaust emissions. These findings are consistent with the results of previous studies of particulate pollution in other urban areas and provide evidence that the coarse fraction of PM10 may affect the health of working people.
Updated estimate for prevalence of chronic hepatitis B among foreign-born persons living in the United States by country of origin
Authors: Robert Wong, Carol Brosgart, Sue Welch, Tim Block, Mark Chen, Chari Cohen, W. Ray Kim, Kris Kowdley, Anna Lok, Naoky Tsai, John Ward, Steven Wong, Robert G. Gish
Journal: Journal of Hepatology (2020)
AIDS-associated non-Hodgkin's lymphoma in San Francisco
Authors: L. D. Kaplan
Journal: JAMA (1989)

The characteristics of acquired immunodeficiency syndrome—associated non-Hodgkin's lymphoma in 84 patients diagnosed and treated at San Francisco General Hospital are presented herein. While the majority were high-grade B-cell lymphomas, one cutaneous T-cell and one peripheral T-cell lymphoma were observed. In addition, three other tumors were suspicious for T-cell lymphoma. Sixty-seven percent of patients had stage IV disease, often at unusual sites. Epstein-Barr virus DNA sequences were identified in only five of 15 tumors by dot-blot analysis. Patients were treated with a variety of standard chemotherapeutic regimens, with radiation therapy alone, or with a novel chemotherapy protocol (COMET-A). No significant differences in complete response rates were observed. The most important predictor of survival was the total number of CD4-positive lymphocytes. Other predictors of survival included history of a diagnosis of acquired immunodeficiency syndrome, Karnofsky performance score, and the presence of extranodal disease. Survival was shorter among patients who received higher doses of cyclophosphamide (&gt;1 g/m<sup>2</sup>), including those treated with the COMET-A regimen. Implications for therapeutic decision making are discussed. (<i>JAMA</i>1989;261:719-724)
The difference
Authors: Fred Charatan
Journal: BMJ (2005)

left ventricular ejection fractions alone, 8%; and with the two factors combined, 17%, indicating an apparently additive risk. Comparison of BNP with NT-proBNPBNP was directly compared with NT-proBNP in only one model.Both log BNP and log NT-proBNP reached significance in univariate analysis, but only log BNP remained significant in the multivariable analysis.
Association News.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Thymic plasma cells
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Colon Vaccines for High Blood Pressure.
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Endocrine colpocytology and cytodiagnosis of ruptured fetal membranes
Authors: H. E. Averette
Journal: JAMA (1967)

During the past ten years at the University of Miami, we have studied the diagnostic value of a rapid staining technique in evaluating vaginal and cervical smears taken from obstetric and gynecologic patients. For obstetric patients, we examined smears for the presence of vernix caseosa or fetal squamous cells. The absence of these cells is a precise indicator of the integrity of fetal membranes in questionable instances of premature rupture of the amnion. For gynecologic patients, our objective was to obtain colpocytologic evidence of estrogen and progesterone production. This is a report of our experiences with vaginal cytology in the daily management of patients. <h3>Staining Technique and Results</h3><h3>Cytodiagnosis of Ruptured Membranes.—</h3> To test for ruptured membranes, cellular samples are obtained by inserting the sterile, gloved index finger in the external cervical os and the middle finger in the posterior fornix. Spreads are made on two clean glass slides and
Rice Burning and Asthma Hospitalizations, Butte County, California, 1983-1992
Authors: Jeffrey Jacobs, Richard Kreutzer, Daniel Smith
Journal: Environmental Health Perspectives (1997)

We investigated the association between rice burning and daily asthma hospitalizations in Butte County, California, from 1983 to 1992. Eighty-two percent of planted rice was burned, with a mean of 555 acres burned on days when burning was permitted. For 60% of the days during this period, no rice burning occurred. Peak burning occurred in fall and spring but was not correlated with criteria pollutants. Asthma admissions averaged 0.65/day and peaked in March. In the basic Poisson model with daily asthma hospitalizations as the outcome of interest, burn acreage showed a small but statistically significant elevation of risk for hospitalization per acre of rice burned [relative risk (RR) = 1.0001; 95% confidence interval (CI), 1. 00004-1.0002], after adjusting for maximum daily temperature, seasonal factors, and yearly population. In this model, burn acreage showed a dose-response effect as acreage burned increased. Days with the greatest acreage burned (>499 acres) had the largest risk of hospitalization (RR = 1.23; CI, 1.09-1.39), and days with moderate burning (between 100 and 499 acres) had a slightly lower risk of admission (RR = 1.2; CI, 1.05-1.37). Elevations of air pollutants were not associated with days of increased rice burning; however, rice burn acreage was shown to have a small but statistically significant effect on asthma morbidity in Butte County. This evidence suggests that further limitations on the daily amount of rice straw permitted to be burned should be considered to reduce pulmonary morbidity related to asthma.
Carcinoma in situ and evaluation of epithelial changes in laryngopharyngeal biopsies
Authors: W. C. Bauer
Journal: JAMA (1972)

In a classic paper published in 1952, Altmann et al<sup>4</sup>first drew attention to a series of patients with carcinoma of the larynx in whom the malignant changes were largely limited to the mucosa. Carcinoma in situ or intraepithelial carcinoma of the larynx and pharynx is now widely recognized, and with few minor variations there is general agreement as to the histologic requirements for the diagnosis.<sup>5-9</sup>These requirements have been spelled out best for lesions of the uterine cervix<sup>10</sup>; we employ them for laryngopharyngeal lesions essentially without change. The characteristics include replacement of the full thickness of the epithelium by cells with the cytologic characteristics of malignancy, a lack of maturation or differentiation, and an absence of invasion. These essential features are depicted in Fig 3. It is generally recognized that the superficial cell layer may show some flattening and minimal piling up of cells, and also
Wolff-Parkinson-White syndrome. Long-term monitoring for arrhythmias
Authors: D. M. Isaeff
Journal: JAMA (1972)

Evaluation of the patient with Wolff-Parkinson-White (WPW) syndrome with tachyarrhythmia is often difficult, since episodes of tachyarrhythmia most often subside spontaneously before medical observation is obtained. Twenty patients with WPW syndrome documented by standard electrocardiogram, who had histories suggesting tachyarrhythmia, were selected for study with the Holter ten-hour ECG monitoring system. This system allowed flexibility of activity during the monitoring period. Episodes of tachyarrhythmia were documented by these techniques in five of the 20 patients studied. Paroxysmal atrial tachycardia was documented in all five, and one patient had both atrial tachycardia and an unrecognized episode of atrial fibrillation. Two patients have been monitored while receiving propranolol hydrochloride therapy, confirming the clinical impression of improvement. Long-term monitoring has been found to be a valuable technique for the evaluation of the patient with WPW syndrome and possible tachyarrhythmias.
Doctors at table
Authors: A. H. Robb-Smith
Journal: JAMA (1973)

Doctors have approached food and drink from many different angles. Earliest, perhaps, are the treatises on health, of which the most famous is the<i>Regimen Sanitatis Salernitanum</i>. In the delightful English translation by Sir John Harington, Queen Elizabeth's godson and reputed inventor of the water closet, the poem opens, The<i>Salerne Schoole</i>doth by these lines impart All health to<i>Englands King</i>, and doth advise From care his head to keepe, from wrath his heart, Drinke not much wine, sup light and soone arise, When meate is gone, long sitting breedeth smart... Use three Physicions still; first Doctor<i>Quiet</i>, Next Dr.<i>Merry-man</i>, and Doctor<i>Dyet</i>. The influence of the Regimen's tenets has been immense. Books on dietetics customarily recount the merits or demerits of various foodstuffs and beverages and advocate special diets. In 1515 Dr. Giovanni Savonarola, grandfather of the Florentine demagogue, discussed in his<i>Libreto</i>, all kinds of foodstuffs.