tbuckley/cabot-search huggingface dataset:
History Lessons
Authors: Jason H. Maley
Journal: Annals of Internal Medicine (2013)

On Being a Doctor19 November 2013History LessonsJason H. Maley, MDJason H. Maley, MDFrom University of Pennsylvania, Philadelphia, Pennsylvania.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-159-10-201311190-00012 Audio Reading - “History Lessons” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "History Lessons," by J.H. Maley. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail It was my first year of medical school, and we were asked to volunteer in the community as part of our curriculum. I chose to volunteer in a primary care clinic serving a residential men's substance abuse treatment center. Late one fall afternoon—my first day—as I turned a corner near the building, I caught a glimpse of the houses lining the street. My anxiety was finally hitting me, along with a fear that as a new medical student, I wouldn't be much help to these patients. A group of men in tattered jeans and t-shirts was gathered on the lawn ... Author, Article, and Disclosure InformationAffiliations: From University of Pennsylvania, Philadelphia, Pennsylvania.Corresponding Author: Jason H. Maley, MD, 1816 Spruce Street, 3F, Philadelphia, PA 19103; e-mail, jason.[email protected]upenn.edu. PreviousarticleNextarticle Advertisement Audio Reading - “History Lessons” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "History Lessons," by J.H. Maley. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics Cited byParenting behaviour and paranoia: a network analysis and results from the National Comorbidity Survey-Adolescents (NCS-A) 19 November 2013Volume 159, Issue 10Page: 715-716KeywordsAnxietyFearHypertensionInsomniaKneesOilsPosttraumatic stress disorderRiversSubstance abuseSurgery ePublished: 19 November 2013 Issue Published: 19 November 2013 Copyright & PermissionsCopyright © 2013 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Catheter-based prostacyclin synthase gene transfer prevents in-stent restenosis in atheromatous rabbits: A potential strategy for therapeutic angiogenesis via vascular endothelial growth factor Mitsunori Harada, Yasushi Numaguchi, Yukio Toki, Hiroyuki Osanai, Takahito Tomida, Michiharu Yamada, Hideo Matsui, Kenji Okumura. International Medicine 2, Nagoya University School of Medicine, Nagoya, Japan, Children's Hospital, Harvard University, Boston, MA
Journal: Journal of the American College of Cardiology (2001)
Psychiatry
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
GRADUATE WORK IN EUROPE FOR THE AVERAGE AMERICAN PHYSICIAN.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Common clinical criteria do not predict spontaneous recovery in non-acetaminophen induced acute liver failure . Mount Sinai Medical Center, New York, N.Y.
Journal: Hepatology (1995)

Background: Although non-A, non-B (NANB) viral hepatitis has been implicated as an etiology of fulminant hepatitis, hepatitis C virus (HCV) has not been shown to result in acute hepatic failure and hepatitis E virus (HEV) has predominantly been associated with fulminant hepatitis among pregnant women. Methods: Using polymerase chain reaction to detect HCV and HEV genomes, four-antigen radioimmunoblot assay (4-RIBA) to measure anti-HCV antibodies, and enzyme-linked immunosorbent assay (ELISA) to detect anti-HEV immunoglobulin M (IgM) antibodies, 17 patients with sporadic fulminant or subfulminant hepatitis of presumed NANB viral etiology were studied. Results: The diagnosis of acute NANB viral hepatitis was made based on clinical information, serological tests, biochemical profiles, and pathological features. All 17 patients were negative for anti-HEV IgM antibodies and HEV RNA in either serum and/or liver. HCV RNAs were detected in 2 patients although anti-HCV antibodies were negative in all of them. Conclusions: It is shown that HCV is infrequently associated with and HEV is not an identifiable cause of presumed NANB fulminant or subfulminant hepatitis in this patient population. Although further studies will be required for identification of the causative agent, it is possible that another agent is responsible for the occurrence of sporadic NANB fulminant or subfulminant hepatitis.
Massive Cardiac Hypertrophy: Report of 15 Hearts Weighing 1,000 Gm or More
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Urinary incontinence.
Authors: B. G. Wise, D. Abbott, C. J. Kelleher, J. Haken, G. Burton, L. D. Cardozo
Journal: BMJ (1992)

factors, we suggest that this has two profound implications: firstly, risk factors in the disease will be defined as those that alter expression of the precursor protein gene, and, secondly, effective treatments of Alzheimer's disease will be those targeted at modulating expression of the precursor protein gene.
Lymphomatoid granulomatosis
Authors: J. G. Rabinowitz
Journal: JAMA (1985)

LYMPHOMATOID granulomatosis (LYG) is a disease entity that shares clinical and histological features with several lesions that affect the lung. The basic histological characteristics of these lesions consist of a combination of granulomatosis and destructive angiitis.<sup>1,2</sup>Our experience with six patients with this entity afforded the opportunity to study the radiological changes and to compare them with those previously described in the literature, as well as with the other granulomatous lesions in this category. The diagnosis of LYG in our cases was confirmed by open-lung biopsy. <h3>Radiological Features</h3> Although the pulmonary manifestations of LYG have been described as fluctuating in presentation and appearance, a few findings in our patients appeared consistent and characteristic. In general, the most typical presentation of LYG consists of a bilateral distribution of multiple nodular densities that tend to favor the basilar pulmonary segments (Figs 1 and 2).<sup>3</sup>Five of our six patients as
Children of home dialysis patients
Authors: M. O. Tsaltas
Journal: JAMA (1976)

Fifteen children of six families in which one parent was undergoing home dialysis were examined by the Minnesota Multiphasic Personality Inventory, human figure drawings, and family interviews. All the children were found to be clinically depressed, and two thirds had a history of being referred by teachers to school counselors and psychiatrists for behavioral problems in school. Of these referred children, all showed disorders of psychomotor activity and reduced academic achievement. There was no clear-cut evidence that these children were depressed because of exposure to home dialysis per se. The most disturbed children seemed to be responding to depressed parents or to partial object loss. A controlled, prospective study is planned to clarify this question. (<i>JAMA</i>236:2764-2766, 1976)
Abstract 4713: Extraction, purification and evaluation of prmt5-inhibitory phytochemical compounds for the treatment of prostate adenocarcinoma
Authors: Oliver H. Richmond, Zhengxin Wang
Journal: Cancer Research (2019)

Abstract The development and advancement of prostate cancer is supported by a plethora of genetic and proteomic abnormalities, including events of post-translational modifications. The protein arginine methyltransferase 5 (PRMT5) enzyme regulates epigenetic events of histone modifications and of post-translational modifications within protein signaling pathways. Under abnormal conditions of overexpression and/or upregulation, PRMT5 functions by constitutively driving the growth and/or proliferation of dysregulated cells. Overexpression and/or upregulation of PRMT5 correlates with disease progression as observed among numerous cancer types, including breast, colorectal, leukemia, lung, melanoma and prostate cancers. We demonstrated previously that PRMT5 localized to the cytoplasm, functions to drive both growth and proliferation of prostatic tumors. Plants naturally produce chemical toxins as mechanisms of defense against microbial and other biological threats. Human exploitation, consumption and/or application of agents isolated from plants for therapeutic intervention dates back throughout the millennia. In this study, we extracted, purified and evaluated natural, small, chemical compounds from plant products that antagonize PRMT5 activity in prostate cancer cells. We found that crude and purified extracts of Dendrobium, Fennel Seed and Magnolia plants attenuated prostate tumor growth and proliferation by selective inhibition of PRMT5 methyltransferase activity. These findings establish the first set of natural PRMT5-specific inhibitors reported. Citation Format: Oliver H. Richmond, Zhengxin Wang. Extraction, purification and evaluation of prmt5-inhibitory phytochemical compounds for the treatment of prostate adenocarcinoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4713.
Premenstrual syndrome and progesterone suppositories
Authors: N. Mackenzie
Journal: JAMA (1991)

<h3>In Reply.—</h3> Dr Mackenzie and Ms Holton, regrettably, have not provided placebo-controlled data to support their statements about progesterone dosage. Our progesterone dose was equal to or higher than that in other controlled studies. We found that symptoms decreased for both progesterone and placebo when the number of suppositories was increased. We therefore would predict that higher dosages may lead to more significant findings in favor of placebo, the opposite of Mackenzie and Holton's prediction. Higher progesterone doses do not seem to be warranted on the basis of our placebo-controlled studies of plasma progesterone levels. To determine whether progesterone was absorbed, we measured plasma progesterone levels before and after administration of 400-mg suppositories. Our published results<sup>1</sup>showed that the serum progesterone levels achieved were consistent with those described in other reports.<sup>2-4</sup>Furthermore, there was a highly significant negative correlation between the duration of treatment and the increase in
NECROLOGY.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction
Journal: BMJ (1959)

Any Questions ?We publish below a selection of those questions and answers which seem of genera!interest.It is regretted that it is not possible to slupply aniswers to all qiuestions submitted.Post-operative Pain Q.-What are the methods at present available for ensuring the minimum of pain and discomfort after a major lower abdominal operation on a patient who is allergic to morphine ?The patient sugers major side-effects from methadone.A.-True allergy to morphine in the form of urticaria, skin rashes, and pruritus is not unknown but is relatively ,uncommon compared with the patient who is over-sensitive and is made distressed by the side-effects of the drug, such as nausea and vomiting.In view of the statement that the patient " suffers major side-effects from methadone " it is probable that she is in the latter category, and, if so, is likely to react in this manner to any effective analgesic.Pethidine (100 mg.) is a suitable pre-operative drug which has certain advantages over morphine, and it is also effective in relieving post-operative pain.Levorphanol (methorphinan) is another synthetic analogue of morphine which could be used in a dose of 2-6 mg.In an attempt to minimize the possible unpleasant side-effects of these drugs they could be given along with one of the tranquillizers, such as promazine (50-100 mg.) or reserpine (0.5-1 mg.).Alternatively the latter drugs might be tried alone, thus avoiding the morphine group of drugs altogether.Finally it might be suggested that this is the type of patient in whom medical hypnosis might be effective. Double BondageQ.-What is the significance of the A in the clhemical -descriptions of the prednisteroids ?Has it anything to do with the position of the carbon atoms in the benzene ring ?A.-The symbol A in the description of steroids refers to the presence of an unsaturated double bond in the molecule.
STARVATION AND OBESITY
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pressure ulcer risk factors among hospitalized patients with activity limitation
Authors: R. M. Allman
Journal: JAMA (1995)

<h3>Objective.</h3> —To identify specific demographic, medical, functional status, and nutritional characteristics that predict the development of stage 2 or greater pressure ulcers among patients whose activity is limited to bed or chair. <h3>Design.</h3> —Prospective inception cohort study. <h3>Setting.</h3> —Tertiary care, urban, university teaching hospital. <h3>Patients.</h3> —A total of 286 patients fulfilling the following criteria: admitted to the hospital within the previous 3 days, age 55 years or more, expected to be confined to bed or chair for at least 5 days or had a hip fracture, and without a stage 2 or greater pressure ulcer. <h3>Main Outcome Measure.</h3> —Time to in-hospital development of a stage 2 or greater pressure ulcer. <h3>Results.</h3> —Total cumulative incidence of pressure ulcers was 12.9% (n=37) after a median time of 9 days from admission to final skin examination. Age of 75 years or more, dry skin, nonblanchable erythema (a stage 1 pressure ulcer), previous pressure ulcer history, immobility, fecal incontinence, depleted triceps skinfold, lymphopenia (lymphocyte count &lt;1.50×10<sup>9</sup>/L), and decreased body weight (&lt;58 kg) were significantly associated with pressure ulcer development by univariate Kaplan-Meier survival analyses (<i>P</i>&lt;.05 by log-rank test). Risk ratios (and 95% confidence intervals) for predictors (<i>P</i>≤.05) of pressure ulcer development after multivariable Cox regression analysis included the following: nonblanchable erythema, 7.52 (1.00 to 59.12); lymphopenia, 4.86(1.70 to 13.89); immobility, 2.36 (1.14 to 4.85); dry skin, 2.31 (1.02 to 5.21); and decreased body weight, 2.18 (1.05 to 4.52). The 3-week cumulative incidence of pressure ulcers with none, one, two, or three or more of these characteristics was 0%, 11.4%, 39.6%, and 67.9%, respectively (<i>P</i>&lt;.001 by log-rank test). <h3>Conclusions.</h3> —These results suggest that nonblanchable erythema, lymphopenia, immobility, dry skin, and decreased body weight are independent and significant risk factors for pressure ulcers in hospitalized patients whose activity is limited to bed or chair. (<i>JAMA</i>. 1995;273:865-870)
IS SERUM HEPATITIS ONLY A SPECIAL TYPE OF INFECTIOUS HEPATITIS?
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Arbeiten über Tropenkrankheiten und deren Grenzgebiete: Bernhard Nocht zu seinem 70. Geburtstag von Freunden, und Schülern gewidmet.
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The extent of coronary artery calcification is associated with clinical predicted risk, but does not predict cardiac complications of elective vascular surgery Joseph Caravalho, Jr., Mary Van Petten, Sean D. O'Donnell, Irwin M. Feuerstein, Patrick G. O'Malley, David L. Gillespie, James M. Goff, Mike Brazaitis, Allen J. Taylor. Walter Reed Army Medical Center, Washington, DC
Journal: Journal of the American College of Cardiology (2001)