tbuckley/cabot-search huggingface dataset:
Has AFIP debugged the cat scratch mystery?
Authors: M. F. Goldsmith
Journal: JAMA (1983)

The discovery of a possible cause for cat scratch disease (CSD), a painful but benign disease that is often undiagnosed or misdiagnosed—partly because its etiology has baffled pathologists for 50 years—was announced recently by researchers at the Armed Forces Institute of Pathology (AFIP), Washington, DC, and the Uniformed Services University of the Health Sciences (USUHS), Bethesda, Md. "We were amazed when we saw them," Douglas J. Wear, MD, of the AFIP, told<i>JAMA</i>MEDICAL NEWS. "We thought if we found bacteria, the illness<i>couldn't</i>be cat scratch disease, because most pathologists leaned toward a virus as being the causative agent." Nonetheless, report Wear and colleagues, delicate pleomorphic gram-negative bacilli appear to be the etiologic agents (<i>Science</i>1983;221:1403-1404). The mysterious disease, which has been known as nonbacterial lymphadenitis, among other things, was first reported in 1950, although even then it had been recognized for at least 20 years. Diagnosis requires that
Sodium Gamma-Hydroxybutyric Acid: New Anesthetic Adjuvant
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MPTH-14. MOLECULAR CLASSIFICATION AND CLINICAL CHARACTERISTICS OF MEDULLOBLASTOMAS IN JAPAN
Authors: Yonehiro Kanemura, Tomoko Shofuda, Koichi Ichimura, Ema Yoshioka, Daisuke Kanematsu, Mami Yamasaki, Soichiro Shibui, Hajime Arai, Michael Taylor, Hiroaki Sakamoto, Ryo Nishikawa
Journal: Neuro-Oncology (2016)

Resent intensive genomic and molecular biological analyses of medulloblastomas have revealed that they are at least classified into four core subgroups: WNT, SHH, Group 3, and Group 4 based on difference in cytogenetics, mutational spectra, and gene expression signatures, as well as in clinical phenotypes and outcomes. This four-subgroup system of medulloblastomas will become not only a novel prognostic marker but also lead to improved diagnosis and risk stratification systems in combination with metastatic, cytogenetics, and or mutational statuses. To deal with this progress, we have founded the Japanese Pediatric Molecular Neuro-oncology Group (JPMNG) and initiated a clinical research project to establish a nationwide network of a molecular diagnosis system for pediatric brain tumors in Japan. Fresh-frozen and/or formalin-fixed paraffin-embedded archived tissue specimens are collected. Diagnostic methods have been optimized to reliably and reproducibly classify them into molecular subgroups according to the consensus criteria. These include gene expression analysis using the NanoString nCounter system, immunohistochemistry, and DNA sequencing. We have so far collected a total of 190 medulloblastomas from 37 hospitals. An analysis using 149 meduloblastomas indicated that proportions of four core subgroups were WNT (12.1%), SHH (28.9%), Group 3 (15.4%) and Group 4 (43.6%), respectively. The frequencies of Group3 are lower and Group 4 is higher than those of published results. CTNNB1 mutations were found in 88.9% of WNT, and TP53 mutations were identified in 17.6% of WNT and 24.3% of SHH, and 1.7% of Group 4. Mutation of TERT promoter was also found in 5 SHH tumors. Prognosis of WNT/SHH was very good, while Group 3 showed the poorest prognosis of all 4 subgroups median survival time being 22.9 months. The JPMNG project will thus improve the molecular diagnosis of pediatric brain tumors, leading to more appropriate treatment choice and better clinical outcomes in Japan.
Starch Gastrolith: Report of a Case of Obstruction
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Metabolism: Nutrients and glutathione
Journal: Hepatology (1995)

Reactive oxygen species generated during the metabolism of the antitumor quinone 3,6-diaziridinyl-1,4-benzoquinone (DZQ) in human colonic carcinoma HCT116 cells lead to the induction of p21 (WAF1, Cip1, or sdi1), an upstream regulator of the retinoblastoma gene product pRb involved G1 cell cycle control. We here demonstrate that the cell cycle was arrested in G2/M phase following supplementation with DZQ of human osteosarcoma Saos-2 cells (lacking both p53 and pRb) and HCT116 cells. DZQ also induced p21 and apoptosis in Saos-2 cells. The transfection of the Rb gene into Saos-2 cells did not alter the level of p21 induction, but changed cell cycle arrest into G1 phase and prevented apoptosis. These findings suggest that quinones may lead to a p53-independent and pRb-preventable G2/M arrest and apoptosis, which correlate with p21 induction.
Antilymphoid Sera In Clinical Renal Allotransplantation
Authors: Robert J. Spencer
Journal: JAMA (1967)

<h3>To the Editor:—</h3> From a clinical trial in renal transplantation of crude γ-globulin derived from horse antihuman lymphoid sera, Starzl and co-workers<sup>1</sup>have noted the unexplained occurrence of pain and tenderness at the site of intramuscular injection and the occurrence of fever. The reported methods of preparation of antilymphoid sera have varied considerably. For example, for experiments on mice Levey and Medawar<sup>2</sup>used thymic cells to immunize rabbits, each rabbit being given two injections of murine thymic cells. In contrast, to prepare sera for clinical use, Starzl and co-workers<sup>1</sup>employed an immunization schedule in which horses received at least four to six injections of human cadaveric lymphoid cells from lymph nodes, from thymus and spleen, or from splenic cells alone. After absorptions of the sera with human erythrocytes and kidney and liver tissues, Starzl and co-workers<sup>1</sup>precipitated the crude γ-globulin with ammonium sulfate, dialyzed it against tap
Plain-film diagnosis of heart disease. A physiologic approach
Authors: E. Gedgaudas
Journal: JAMA (1975)

A CLINICAL evaluation, electrocardiogram, and roentgenologic study of the chest with barium swallow form the classic triad on which the diagnosis of cardiac disease rests. The four views of the heart with barium in the esophagus give information about the state of the pulmonary vasculature, heart size and contour, differential enlargement of chambers, relationship and size of the great vessels, and the presence of calcifications within the cardiac shadow or in the vessels. Such information may add new dimensions or only confirm the clinical impression. It may also provide important practical information in planning a catheterization or surgical approach; eg, awareness of an aberrant right subclavian artery would rule out the use of the right brachial artery as an approach to the ascending aorta and left ventricle at cardiac catheterization; the presence of a right aortic arch would suggest to the surgeon the use of the left subclavian artery for
The 'grand conspiracy' against the cancer cure
Authors: W. Regelson
Journal: JAMA (1980)

IN BOTH randomized double-blind and nonrandomized studies, our group and others have tested hydrazine sulfate in advanced-stage cancer patients and found it to have little value.<sup>1-4</sup>If our clinical impressions are true, why does publicity engendered by<i>Penthouse</i>magazine, Gold,<sup>5</sup>and Russian reports<sup>6-8</sup>as to hydrazine's value contradict our experience? I first heard of hydrazine from Joseph Gold, MD, of the Syracuse Cancer Research Institute in the spring of 1973. To his credit, the use of hydrazine was based on his original concept that the glycolysis of cancer cells and the presence of cancer stimulated gluconeogenesis, which constituted a systemic metabolic circuit capable of drawing substantial amounts of energy from the cancer host.<sup>9-10</sup>Dr Gold postulated that this mechanism of energy loss was responsible for cancer cachexia, which he believed could be reversed by metabolically interrupting gluconeogenesis. Based on Gold's<sup>11,12</sup>concept that he could reverse
Typographical Error in Reports of a <i>P</i> Value
Authors: Carrie Colla, Valerie Lewis, Lee-Sien Kao, Ba James O'malley, Chiang-Hua Chang, Elliott Fisher, O Kao, O Lewis
Journal: JAMA Internal Medicine (2017)

Jane M. Liebschutz, MD, MPH; Ziming Xuan, ScD, SM; Christopher W. Shanahan, MD; Marc LaRochelle, MD, MPH; Julia Keosaian, MPH; Donna Beers, MSN, RN-BC, CARN; George Guara, RN, BSN; Kristen O’Connor, RN, BSN; Daniel P. Alford, MD, MPH; Victoria Parker, DBA, EdM; Roger D. Weiss, MD; Jeffrey H. Samet, MD, MA, MPH; Julie Crosson, MD; Phoebe A. Cushman, MD; Karen E. Lasser, MD, MPH
DEATHS AND ACCRETIONS IN THE MEDICAL PROFESSION.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nature, London
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Expression of MYC but Not pSTAT3 Is an Adverse Prognostic Factor for Diffuse Large B Cell Lymphoma (DLBCL) Treated with Epratuzumab/R-CHOP
Authors: Mamta Gupta, Matthew J Maurer, Linda Wellik, Mark E Law, Jing Jing Han, Ivana N. Micallef, Ahmet Dogan, Thomas E. Witzig
Journal: Blood (2012)
Pathogenic Factors in Cirrhosis With and Without Hepatocellular Carcinoma: A Multicenter Italian Study
Authors: Carlo De Bac, Tommaso Stroffolini, Giovanni B. Gaeta, Gloria Taliani, Giuseppe Giusti
Journal: Hepatology (1994)

We designed a multicenter cross–sectional study to evaluate the role of alcohol abuse, the hepatitis viruses and other pathogenic factors in cirrhosis and hepatocellular carcinoma. A total of 1,829 consecutive cirrhosis patients, with or without HCC, was enrolled over 6 mo in 21 centers throughout Italy. The etiological categories and diagnostic criteria were preestablished. The median age of the patients was 59 yr (range, 13 to 85 yr); 63.6% of the patients were graded as Child class A, 23.4% as Child class B and 13% as Child class C. Hepatitis C virus antibodies were found in 72.1% of cases (47.7% alone, 21.2% with alcohol abuse, 3.2% with hepatitis B virus); HBsAg was present in 13.8% (4.2% alone, 3.2% with hepatitis D virus, 3.2% with hepatitis C virus, 3% with alcohol abuse), alcohol abuse with no concomitant viral infection was recorded in 8.7%, primary biliary cirrhosis was found in 1.8%, other causes were found in 1.4% and cryptogenic cirrhosis was only present in 5.3%. Hepatocellular carcinoma was detected in 11.9% of patients (217 cases). The presence of hepatocellular carcinoma was more frequent in males than females (14.7% vs. 7.3%; p &lt; 0.001) and increased with worsening Child class (8.3% in Child class A, 16.9% in Child class B, 19.9% in Child class C, p &lt; 0.001). The highest prevalences of hepatocellular carcinoma were observed in hepatitis B virus infection, with or without alcohol abuse (20% and 16%, respectively) and in hepatitis C virus cirrhosis, with or without alcohol abuse (16% and 10.3%, p &lt; 0.005). Our data indicate chronic viral infection to be responsible for most cirrhosis and hepatocellular carcinoma in Italy. This finding may aid development of guidelines for prevention programs. (Hepatology 1994;20:1225-1230).
Incorrect Signature
Journal: JAMA (1980)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Health and mental health problems of homeless men and women in Baltimore
Authors: W. R. Breakey
Journal: JAMA (1989)

A study of homeless people in Baltimore, Md, focused on their health and other characteristics, with special emphasis on their needs for services. In the first stage, 298 men and 230 women were randomly selected from the missions, shelters, and jail in Baltimore to respond to a baseline interview that provided extensive sociodemographic and health-related data. In the second stage, a subsample of 203 subjects was randomly selected from the baseline survey respondents to have systematic psychiatric and physical examinations. Data are presented from both stages. Data from the first stage demonstrate, among other things, the high levels of disaffiliation of this population and their heavy involvement in substance abuse. Data from the clinical examinations demonstrate the high prevalence of mental illnesses and other psychiatric disorders and of a wide range of physical disorders and confirm the high prevalence of alcohol abuse disorders. The high rates of comorbidity of these conditions is demonstrated and data are provided on the subjects' needs for mental health and substance abuse services. (<i>JAMA</i>. 1989;262:1352-1357)
Evaluating health system reform. The case for a single-payer approach
Authors: J. McDermott
Journal: JAMA (1994)

THROUGHOUT history, the medical profession has struggled in its conflict between belief and science. In the late 18th century, this struggle was exemplified by a religious adherence to Dr Benjamin Rush's theory that bleeding patients would restore health. The result of this mistaken belief—as opposed to proven hypothesis—was that George Washington is historically thought to have been bled to death therapeutically. Two hundred years later, American medicine is still locked in its ambivalence between science and belief. But in 1993, the issue is health care system reform. In the debate emerging from the presentation of President Clinton's plan, the challenge for our profession will be whether it can move beyond time-honored mantras to examine objectively and scientifically the options with which it is presented. <h3>THE NEED FOR CHANGE</h3> Few would dispute the need for change. American physicians are the most dissatisfied and frustrated in the industrialized world.<sup>1</sup>Approximately 15%
Medical News
Journal: JAMA (1978)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correlation of pathologic findings after brief neoadjuvant sorafenib with results of dynamic-contrast enhanced (DCE) and diffusion-weighted magnetic resonance imaging (DW-MRI) in patients with locally advanced or metastatic clear cell renal cell carcinoma (RCC).
Authors: Gary R. MacVicar, Frank Miller, Rahul Rustogi, Zong-Ming Chen, Brenda K. Martone, Timothy Kuzel
Journal: Journal of Clinical Oncology (2013)

466 Background: Many pts receiving tyrosine kinase inhibitors for RCC manifest stable disease as their best response by RECIST criteria. We hypothesized that tumor necrosis by DCE and DW-MRI after brief treatment with neoS may correlate with pathologic findings. We investigated in a pilot study whether these MRI changes may serve as an imaging biomarker predictive of clinical outcome. Methods: Pts with locally advanced or metastatic clear cell RCC undergoing nephrectomy or metastastectomy were treated with neoS 400mg PO bid for 28 days prior to surgery. The feasibility and safety of neoS was determined. Tumor necrosis detected by DCE and DW MRI’s pre- and post-neoS were compared and correlated with survival and pathologic findings at surgery. RECIST/WHO criteria were also compared. Results: 9 pts were enrolled, and all underwent surgery after neoS, 4 weeks (n=7) or less for toxicity (n=2). Clear cell/sarcomatoid histology was noted in 8 pts, and papillary in 1. All pts had T3 or T4 disease. 7 had M1 disease. No surgical complications occurred. 7 pts (78%) experienced grade 3 toxicities, including hypertension (n=1), pancreatitis (n=1), hand-foot syndrome (n=1), hyponatremia (n=2), and rash (n=2). No grade 4 or 5 toxicities were observed. 4 of 8 clear cell/sarcomatoid pts (50%) have died, 3 because of progressive disease and 1 of unrelated causes. DCE and DW MRI’s with direct surgical pathological correlation were available in 7 of these pts. The mean ADC DW MRI changes in the renal lesion of 4 longer term survivors (median survival = 43 months) was +.22 vs. –0.07 in the 3 short term survivors (median survival = 13 months). RECIST/WHO criteria did not correlate with response. Evaluation of lack of enhancement on DCE MRI and increase in ADC on DW MRI were seen and correlated with necrosis on pathologic specimens. Conclusions: Four weeks of neoS is associated with significant necrosis that correlates with DCE-MRI and DW-MRI. There may be a trend in survival with greater necrosis, suggesting a role for these imaging biomarkers to assess early benefits of therapy. Clinical trial information: NCT00727532.
Bloodless Circumcision
Authors: John M. Birnie
Journal: New England Journal of Medicine (1945)

AN OPERATION for circumcision is often brushed aside as unworthy of the efforts of a qualified surgeon, and relegated to an intern or occasional operator without adequate instruction or supervision. The resulting hemorrhage, edema, swelling or even malformation reflects little credit on the medical profession.The operative steps presented in this paper are designed to obviate these annoying incidents, which sometimes occur even in the practice of the more experienced surgeon. The procedures advocated are based on anatomic facts, so that it will be well to review the essential points involved.The skin covering the pendulous portion of the penis . . .