tbuckley/cabot-search huggingface dataset:
Incorrect Description of Drug Act
Journal: JAMA (2019)

In the Viewpoint entitled "The Orphan Drug Act Revisited," 1 published in the March 5, 2019, issue of JAMA, there was incorrect wording used to describe the Orphan Drug Act.In all instances, "patent protection" and "patent exclusivity" should have read "market exclusivity."The sentences should have read as follows: "To promote the development of orphan drug therapies, the ODA provided companies that engaged in research for drugs with populations of fewer that 200 000 patients with tax incentives, research substudies, and extended market exclusivity"; "These impressive revenues do not consider the substantial financial incentives companies receive in fee waivers and extended market exclusivity"; and "Another possibility would be to enact price regulations for orphan drugs after their extended market exclusivity expires, if no generic competition has arisen."This article was corrected online.
THE ROUTE AND RESULTS OF OUR FIRST INFECTION WITH TUBERCULOSIS
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Benevolent 'world war' declared on humanity's longtime disease foes
Authors: C. Marwick
Journal: JAMA (1984)

The techniques of modern molecular biology are opening promising avenues for the World Health Organization's long-sought goal for the ultimate control of six major tropical diseases—malaria, filariasis, trypanosomiasis, leprosy, schistosomiasis, and leishmaniasis. Among the recent advances in some of these diseases: A candidate vaccine against leprosy is currently undergoing clinical trials; A vaccine against malaria is in sight, and improved drugs, including a new agent from the People's Republic of China, are under active investigation; A new drug for the management and perhaps even prevention of onchocerciasis, or river blindness, is undergoing an extended field trial; Finally, a well-studied and highly promising candidate vaccine against the rotavirus responsible for diarrheal diseases of infants and children is at hand and may be ready for use in a year or two. In addition, novel strategies are being instituted for the better control of many of the
Diseases of the Chest, Chicago
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
“Consensus statement for inert gas washout measurement using multiple- and single-breath tests.” Paul D. Robinson, Philipp Latzin, Sylvia Verbanck, Graham L. Hall, Alexander Horsley, Monika Gappa, Cindy Thamrin, Hubertus G.M. Arets, Paul Aurora, Susanne I. Fuchs, Gregory G. King, Sooky Lum, Kenneth Macleod, Manuel Paiva, Jane J. Pillow, Sarath Ranganathan, Felix Ratjen, Florian Singer, Samatha Sonnappa, Janet Stocks, Padmaja Subbarao, Bruce R. Thompson and Per M. Gustafsson.<i>Eur Respir J</i>…
Authors: Paul Robinson, Philipp Latzin, Sylvia Verbanck, Graham Hall, Alexander Horsley, Monika Gappa, Cindy Thamrin, Hubertus Arets, Paul Aurora, Susanne Fuchs, Gregory King, Sooky Lum, Kenneth Macleod, Manuel Paiva, Jane Pillow, Sarath Ranganathan, Felix Ratjen, Florian Singer
Journal: European Respiratory Journal (2013)
Abstract 244: Cancer stem cells predict engraftment and poor prognosis of primary breast tumor.
Authors: Emmanuelle Charafe-Jauffret, Christophe Ginestier, Francois Bertucci, Olivier Cabaud, Jose Adelaide, Max Chaffanet, Luc Xerri, Patrice Viens, Daniel Birnbaum
Journal: Cancer Research (2013)

Abstract Despite the promise of the cancer stem cell (CSC) model, its clinical relevance remains to be proven in breast cancer (BC) and requires a sensitive xenograft assay to define CSC on key functional properties i.e tumorigenicity, self-renewal and differentiation potential. We report the establishment of primary breast tumor-derived xenografts (PDXs) that retain main primary tumors features (histo-phenotypic, molecular and genomic features, hierarchical organization of the tumoral cell population). We demonstrate that success in engraftment is correlated with the presence of CSC in primary tumor and predicts prognosis in patients (HR= 3.61; 95%CI [1.12-11.65], p=3.20E-02). The xenograft assay demonstrated the hierarchical organization of BC. Analysis of gene expression from functionally validated CSC yield to a breast CSC signature (BCSC-GES) is an independent predictor of patient survival. We then identified a core of genes commonly expressed by BCSC and embryonic, hematopoietic, neural stem cells, the CE-4SC. This shared transcriptional program comprised 19 genes encoding mismatch and nucleotide excision repair proteins, proteins implicated in transport through the endoplasmic reticulum, RNA processing, translation and transcriptional regulators, enzymes of detoxification and mitochondrial/oxidative stress, or enzymes of lipid metabolism. This “universal” stem cell program is also an independent predictor of patient survival. Using a screening of an RNA-interference library specially designed to block the expression of these 19 target genes, we validated the effect of single gene knock-down (KD) on the breast CSC population for 14 genes (KD of 5 genes decreased the CSC population and were called “self-renewers”genes, KD of 9 genes increased the CSC, and were designated as“differentiators”). Hence, this study validated the clinical relevance of CSC model in breast cancer for the first time, and the ability of PDXs to accelerate transfer for personalized CSC therapy into clinics. Citation Format: Emmanuelle Charafe-Jauffret, Christophe Ginestier, Francois Bertucci, Olivier Cabaud, Jose Adelaide, Max Chaffanet, Luc Xerri, Patrice Viens, Daniel Birnbaum. Cancer stem cells predict engraftment and poor prognosis of primary breast tumor. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 244. doi:10.1158/1538-7445.AM2013-244
Multicenter Phase I Trial of Intraventricular Immuno-Chemotherapy in Recurrent CNS Lymphoma
Authors: James L. Rubenstein, Lingjing Chen, Ranjana Advani, Jan Drappatz, Elizabeth Gerstner, Tracy Batchelor, Hendrikus Krouwer, Cigall Kadoch, Pamela Munster, Soonmee Cha, Marc A Shuman, Lloyd E. Damon
Journal: Blood (2011)
Obstetrics
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Home Exam
Authors: Phoebe Prioleau
Journal: Annals of Internal Medicine (2018)

Ad Libitum19 June 2018Home ExamPhoebe Prioleau, MD, MPHPhoebe Prioleau, MD, MPHUH Rainbow Babies and Children's Hospital, Cleveland, Ohio (P.P.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M18-0968 Audio Reading - “Home Exam” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Home Exam," by P. Prioleau. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail One: bananaTwo: sunriseThree: chair“Remember for later,” I say.Now you fill in numbers on a clock.You fix your glasses, focus on the task.First, six,almost down the center.Next, five, four, three:you work counterclockwiseback around.I take the sheet of paper.You forgot the hour hand andtwelve is missing.You can't recall our words.“No good in guessing,”you tell me.It's time to leave your kitchen table.As I gather my things,you split two bananaslike a wishboneand offer me the fruit. Author, Article, and Disclosure InformationAffiliations: UH Rainbow Babies and Children's Hospital, Cleveland, Ohio (P.P.)Current Author Address: Phoebe Prioleau, MD, MPH; e-mail, phoebe.[email protected]org. PreviousarticleNextarticle Advertisement Audio Reading - “Home Exam” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Home Exam," by P. Prioleau. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 19 June 2018Volume 168, Issue 12Page: 880 ePublished: 19 June 2018 Issue Published: 19 June 2018 Copyright & PermissionsCopyright © 2018 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
LETTER FROM LONDON.
Authors: None G. O. M.
Journal: JAMA (1890)

(FROM OUR OWN CORRESPONDENT.) <i>Prof. Koch and his reported cure for Consumption—The Tortoise Field Hospital Equipment— Medicinal Rings—Hydro-chlorate of Glutin-Peptone —Miscellaneous Gleanings</i>. Professor Koch's reported cure for consumption arouses intense interest and expectation in the Teutonic medical world. After long experiments Dr. Koch has so far perfected the discovery that he will give a full account of his method in a public lecture at the December meeting of the Berlin Medical Association. He does not expect to cure patients in an advanced state of the disease, because other parasites have then attacked the lungs while his remedy only kills the tuberculosis bacillus. But he is certain of success in the early stages, his process being curative, not preventive, like vaccination, although it resembles the latter process by lymph being injected under the skin. Eight persons are now undergoing the cure at a Berlin hospital. The Government will establish a Bacteriological
Laryngocele and Laryngopyocele. A Differential Diagnosis of Swellings in the Anterior Triangle of the Neck
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cardiopulmonary Resuscitation
Authors: Michael D. Yablonski
Journal: JAMA (1978)

<h3>To the Editor.—</h3> The article in the MEDICAL NEWS section (239:391-392, 1978) discussing physician scores in cardiopulmonary resuscitation (CPR) brings into focus an important deficit in house officer education. Julian<sup>1</sup>suggested in 1961 that all of the medical nursing and auxiliary staff should be trained in the techniques of closed chest cardiac massage and mouth-to-mouth breathing. The National Conference on Cardiopulmonary Resuscitation and Emergency Cardiac Care (ECC) recommended that CPR training be included in the secondary school curriculum in 1973.<sup>2</sup>A similar recommendation was made by the World Health Organization<sup>3</sup>in a 1975 report. The essential but often "missing link" in the ECC system is CPR, designed to treat sudden death both inside and outside the hospital. The American Heart Association has taken the lead in promoting CPR and advanced life support (ALS) training. However, some in the medical profession have remained slow to respond. Moreover, the attitude
Child Maltreatment
Authors: Dante Cicchetti, Sheree L. Toth
Journal: Annual Review of Clinical Psychology (2004)

Child maltreatment exemplifies a toxic relational environment that poses significant risks for maladaptation across biological and psychological domains of development. Research on child maltreatment can inform developmental theory, but more importantly, it can enhance the quality of clinical, legal, and policy-making decisions for maltreated children. This chapter addresses definitional, epidemiological, and etiological aspects of child maltreatment. A developmental psychopathology perspective is directed toward the discussion of the psychological and neurobiological sequelae of child maltreatment. Implications for prevention, intervention, and social policy are discussed, and recommendations for future research are proffered.
Questions and Answers
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Process-Dependent Risk of Delayed Health Effects for Welders
Authors: Richard M. Stern
Journal: Environmental Health Perspectives (1981)

In most industrialized countries large numbers of workers are exposed to welding fumes. Although the general pattern of welders' health may not significantly differ from that of workers in other dusty industrial occupations which demonstrate elevated incidence of respiratory tract diseases with long latency periods, the extremely wide range of substances at potentially high concentrations produced by various welding technologies may give rise to undetected process-specific high-risk working conditions: ("hot spots"). The origin, prevalence and range of magnitude of such hot spots, especially for cancer of the respiratory tract, is discussed, with emphasis placed on the assessment of risk resulting from exposure to Cr(VI) and Ni accompanying the use of various technologies for the welding of stainless and high alloy steels. The wide variation of health effects found within the industry, however, indicates the need for a standard protocol for future epidemiological studies, as well as for the development of suitable methodologies for experimental risk assessment.
Benzene-Induced Myelotoxicity: Application of Flow Cytofluorometry for the Evaluation of Early Proliferative Change in Bone Marrow
Authors: Richard D. Irons
Journal: Environmental Health Perspectives (1981)

A detailed description of flow cytofluorometric DNA cell cycle analysis is presented. A number of studies by the author and other investigators are reviewed in which a method is developed for the analysis of cell cycle phase in bone marrow of experimental animals. Bone marrow cell cycle analysis is a sensitive indicator of changes in bone marrow proliferative activity occurring early in chemically-induced myelotoxicity. Cell cycle analysis, used together with other hematologic methods, has revealed benzene-induced toxicity in proliferating bone marrow cells to be cycle specific, appearing to affect a population in late S phase which then accumulate in G2/M.
Two New Approaches to the Diagnosis of Thyroid Disorders
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE TRANSACTIONS OF THE FIRST PAN-AMERICAN MEDICAL CONGRESS.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SOME RECENT OBSERVATIONS CONCERNING BACILLARY DYSENTERY.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal