tbuckley/cabot-search huggingface dataset:
Protease inhibitors bring new social, clinical uncertainties to HIV care
Authors: R. Voelker
Journal: JAMA (1997)

LAZARUS NEVER had a Visa card charged to the hilt. Or a life insurance policy that was sold at maybe 60% of its face value. Or the prospect of going back to work while having to maintain a complex regimen of multiple antiretroviral drugs. For clinicians, politicians, and patients with the human immunodeficiency virus (HIV), the era of life-prolonging treatment with protease inhibitors has become as much a cause of uncertainty as it is of celebration. Even though optimism about powerful new drug combinations has been widespread, "we are on the threshold of a new set of problems with these treatment modes," said Willie Brown Jr, mayor of San Francisco, Calif, where a multidisciplinary group of people with HIV, clinicians, and social and legal services workers met last month for the 9th National AIDS Update Conference. <h3>Back to Work Issues</h3> For many patients who have had success with combination therapy
Hippocrates of Ostia
Authors: D. W. Richards
Journal: JAMA (1968)

My purpose is to give you a description and a picture of Hippocrates, as accurate and vivid a picture as I can, to include what he looked like, and also what he was. How is it possible to reach back into the shadows, 2,400 years ago, find the man, distinguish and identify him out of the myths, legends, and errors that obscure him? There have been biographies, those now extant having been written many centuries after his death; there are a few contemporary references; there are the man's own writings and those of his school; and there are coins, statuary, and mosaics representing his likeness with greater or lesser authenticity—these almost wholly of the Roman era or later. Hippocrates was born on the island of Cos, near the Asian mainland, about 460 BC, and died and was buried near Larissa in Thessaly, around 370 or 360 BC. His life spanned
Lipid Absorption and Metabolism
Authors: A. Kuksis, N. A. Shaikh, A. G. D. Hoffman
Journal: Environmental Health Perspectives (1979)

Metabolic processes occurring within the mucosal cell are critical in determining results of interactions between environmental agents and the alimentary tract. The absorption, metabolism, and transport of lipids affects most those agents which are lipid soluble. The understanding of the process involved in lipid absorption and transport is therefore important for both appreciation of the mechanism of uptake of these toxins and for an effective interference with it. Most of the detailed mechanisms of lipid absorption and transport have been proposed from in vitro studies with soluble cell-free systems. The present review integrates these results with recent in vivo and in vitro findings with intact animal tissues and isolated mucosal cells. While there is much general agreement occasional startling differences are also observed, which may have a bearing on the mechanism of normal fat absorption and on the understanding of the transport of the fat-soluble toxins across the mucosal villus cell.
End-of-Life Compassion
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pituitary ablation and disseminated prostatic carcinoma
Authors: C. R. West
Journal: JAMA (1973)

Twenty-seven patients with disseminated carcinoma of the prostate underwent adenohypophysectomy by either open craniotomy (8 patients) or stereotaxic cryohypophysectomy (19 patients). All patients had growth hormone assay following insulin-induced hypoglycemia during the preoperative (control) period and twice during the postoperative (experimental) period. In the postoperative tests, a 73% or greater suppression of growth hormone levels following hypoglycemia correlated with significant clinical remission and prolongation of survival. The minimal degree of growth hormone suppression consistent with clinical remission and extended survival was shown to be between 22% and 73% (as compared with preoperative control values). Subtotal hypophysectomy is adequate to achieve significant clinical remission and extended survival. Growth hormone assay is a useful index of the adequacy of hypophysectomy.
Clinical Science, London
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The medical curriculum and human values. Panel discussion
Authors: C. Truett
Journal: JAMA (1969)

The student presentation before the Congress on Medical Education on "Medical Curriculum and Human Values" represented a radical change in student input. Originally, the student panel was designed to respond only to the faculty presentations. However, following the student confrontation before the Association of American Medical Colleges deans' meeting, it was appropriately decided that what the students had to say was more important. To facilitate the presentation, the subject was divided into four major parts, with each student presenting one part. Casey Truett began with an analysis of human values in present curriculum. Art Douville then indicated how concern over loss of human values in medical school was being transformed into activism. Bruce Fagel followed with a survey of student activism and a review of the present status of student programs in curricular reform. Merle Cunningham then concluded with a look toward the future and an appeal for cooperation from
Regression of coronary atherosclerosis during treatment of familial hypercholesterolemia with combined drug regimens
Authors: J. P. Kane
Journal: JAMA (1990)

We conducted a randomized, controlled trial in 72 patients with heterozygous familial hypercholesterolemia to test whether reducing plasma low-density lipoprotein levels by diet and combined drug regimens can induce regression of coronary lesions. Four hundred fifty-seven lesions were measured before and after a 26-month interval by computer-based quantitative angiography. The primary outcome variable was within-patient mean change in percent area stenosis. Mean low-density lipoprotein cholesterol levels decreased from 7.32 ±1.5 to 4.45 ±1.6 mmol/L. The mean change in percent area stenosis among controls was + 0.80, indicating progression, while the mean change for the treatment group was -1.53, indicating regression (<i>P</i>=.039 by two-tailed t test for the difference between groups). Regression among women, analyzed separately, was also significant. The change in percent area stenosis was correlated with low-density lipoprotein levels on trial. We conclude that reduction of low-density lipoprotein cholesterol levels can induce regression of atherosclerotic lesions of the coronary arteries in patients with familial hypercholesterolemia. The anticipation of benefit from treatment applies to women and men alike. (<i>JAMA</i>. 1990;264:3007-3012)
ABC of Antenatal Care: Medical problems in pregnancy--I
Journal: BMJ (1991)

Site of cervi{ Succent ulo-. Main placentaVasa praevia.A succenturiate lobe is separated from the main body of the placenta.Should the vessels run over the cervix, when the cervix dilates they may be torn so that fetal blood is lost.The relative risks of increased perinatal mortality from antepartum haemorrhage compared with those in pregnancies with no such haemorrhage.
Fetotoxic Effects of Mono-2-Ethylhexyl Phthalate (MEHP) in Mice
Authors: Isao Tomita, Yoshiyuki Nakamura, Yasuoki Yagi, Kiyosi Tutikawa
Journal: Environmental Health Perspectives (1986)

Mono(2-ethylhexyl) phthalate (MEHP), one of the main metabolites of di(2-ethylhexyl) phthalate (DEHP), exerted embryo/fetotoxic effects similar to those of DEHP at lower doses.Oral administration of MEHP (1 mL/kg) to the mice of 8 days gestation resulted in less than 32% of live fetuses, all of which were deformed.When DEHP (10 mL/kg) was given to the pregnant mice of 8 days gestation, approximately 0.03% and 0.003% of the administered dose was found in fetuses as DEHP and MEHP, respectively, after 12 hr.The presence of the MEHP in fetuses is probably due to the transplacental crossing of the MEHP formed in the maternal body, since the fetuses of mice up to day 9 of pregnancy showed no hydrolytic activity of DEHP to MEHP.Crossing of MEHP through the placenta was proven by an experiment in which MEHP was administered in pregnant mice.A single injection of MEHP (25 or 50 mg/kg), but not DEHP (500 mg/kg) into pregnant mice, induced a significantly high incidence of somatic mutations in the coat hair of offspring of mice (KYG, 9 x PW, d; C57BL/6Crj, 9 x PW, 6).All these data suggest that MEHP could be responsible for the embryotoxic/ fetotoxic effects observed with DEHP.* Significantly different from untreated controls at 99% level (p <0.01).
How to approach universal access to basic medical care without our government doing it
Authors: G. D. Lundberg
Journal: JAMA (1995)

Everything has changed. Nothing has changed. None of the big problems with our health system—primarily insurance coverage—have been solved. The biggest problem continues to be our 40 million or so with no sickness insurance on any one day.<sup>1</sup>Since our federal government has been unable to assure universal coverage, it falls by default to the private sector to do so. See also p 243-257. As members of a learned profession, physicians have traditionally been expected to give away free care to those who need it and can't pay for it.<sup>2</sup>In this impending era of domination by for-profit health industry participants such as insurance companies, managed care organizations, hospitals, drug manufacturers and, yes, for-profit physicians, it falls to all of them to help to achieve universal access to basic care for our uninsured.THE JOURNALcalls on all players in the entire health industry—for-profit and not-for-profit—to give away
Cold facts concerning hypothermia
Authors: P. Gunby
Journal: JAMA (1980)

A woman is found in the snow with much of her clothing removed. Looking at the cold, still body, police conclude that she may have been raped and murdered during the night. They begin to cordon off the area and urge others at the scene, including a physician, to stay away from the body in order to preserve clues. As underwater oil exploration proceeds in the North Sea, an average of six divers a year die. For at least half of these deaths, there is no—or only a partial—explanation. In addition, many other divers do not die but suffer unexplained confusion or loss of consciousness. Virtually all participants in a recent Kingston, RI, conference would counsel the physician in the first case not to be put off by the police but to examine the woman. The main reason? She may not be dead. An oft repeated maxim in
Mutations in complement C3 predispose to development of atypical hemolytic uremic syndrome
Authors: Veronique Frémeaux-Bacchi, Elizabeth C. Miller, M. Kathryn Liszewski, Lisa Strain, Jacques Blouin, Alison L. Brown, Nadeem Moghal, Bernard S. Kaplan, Robert A. Weiss, Karl Lhotta, Gaurav Kapur, Tej Mattoo, Hubert Nivet, William Wong, Sophie Gie, Bruno Hurault de Ligny, Michel Fischbach, Ritu Gupta, Richard Hauhart, Vincent Meunier, Chantal Loirat, Marie-Agnès Dragon-Durey, Wolf H. Fridman, Bert J. C. Janssen, Timothy H. J. Goodship, John P. Atkinson
Journal: Blood (2008)
Dosage Error
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Film Reviews
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Public Service.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Errata
Journal: Journal of Clinical Oncology (2017)

The third sentence of the second paragraph of the Introduction section previously read: "Many men with androgen-sensitive disease who receive ADT will develop biochemical, radiographic, and/or symptomatic evidence of cancer progression despite castrate levels of testosterone (, 50 ng/mL or , 1.7 nmol/L). 3,4" This should have read: "Many men with androgensensitive disease who receive ADT will develop biochemical, radiographic, and/or symptomatic evidence of cancer progression despite castrate levels of testosterone (, 50 ng/dL or , 1.7 nmol/L). 3,4" This has been corrected as of November 13, 2017.The authors apologize for the error.
JAMA Psychiatry
Authors: Phil Fontanarosa, Annette Flanagin, Brenda Gregoline, Tracy Frey, Kevin Brown, Amanda Ehrhardt, Iris Lo, M Newman, Suzanne Walker, Connie Manno, Sara Billings, Timothy Gray, Paul Ruich, Sam Wilder, Catherine Alden, Stephanie Beckmeyer, Jane Calayag, Jan Clavey, Mary Coerver-Connolly, Paula Glitman, Laura King, Regina Lilly, Joseph Mills, Brandy Patton, Thressa Smith, Donna Thordsen, Aggie Zarkadas, Wanda Assistant, Larry Bryant, Monica Mungle, Elaine Williams, Fanny Brown, Anna Bukowski, Lenette Gardner-Gullens, Tosca Hall, Erin Kato, Peter Kim, Rachell Lozano, Caroline Sietmann, Angelia Waltower, Michael Berkwits, Eric Butkus, Michelle Kurzynski, Emily Ling, Jesse Mcquarters, Daniel Morrow, Daniella Peting, Reuben Rios, Carrie Butt, Mary Ferkaluk, Ronna Henry, Karen Bucher, Andy Rekito, Nick Reback, David Song, Deputy Livingston, Thomas Cole, Marla Hall, Deanna Willis, Yolanda Davis, Joseph Thornton, Deanna Bellandi, Jim Managers, Fergus Clare, Lindsay Dawson, Ellen Gibson, Mustafa Ishaq, Peter Litton, Craig Mccaff Rey, Michael Mcgraw, Regina Nisengolts, Jon Perkins, Daniel Pickhardt, Romando Rossini, Sarah Subramanian, Stacy Business, Analyst Sirisha, Alluri Staff, Millette Jackson-Bates, Tom Miller, Karl Elvin, Nancy Essex, Jaye Mize, Sean O'donnell, Sue Managers, David Antos, Anthony Bautista, Chris Borden, Debbie Camp, Jennifer Carney, Lydia Cruz, Scott Curl, Diane Darnell, Jordynn Farrar, Allison Hughes, Colleen Kelly, Chris Meyer, Annemarie Neff, J Neff, Sean Ohlson, Phil O'leary, Bill Pedone, Susan Price, Binita Shah, Erin Spencer, Denise Steinhauser, Joe Advertising, Production Services, Ahmed Avendano, Kim Boler, Rhonda Brown, Fin Carter, Michael Deegan, Daniel Degroot, Euwanaha Joiner-Smith, Joshua Lane, Cindy Rendlen, Ellen Yoshihara, Circulation Services, Julie Burton, Ronna Hewitt, Mary Sieck, Geneine Someren, Jamaal Vargas, New Media, Gail Barrett, Regina Brownlee, Amanda Camino, Brenda Chandler-Grayer, Emily Dunn, Amy Evers, Maleeka Holden, Teri Hutchison, Joshua Lampinen, Nathan Mitre, Patricia Panek, Marla Seidell, La Son, Diggs Sledge, Julian Graphics, Joe Amft, James Collver, Maria Duda, Fred Furtner, Carolyn Hall, Maria Kowalkowski, Carla Benton, Carol Farrell, Daniel James, Judith Literskis, Teresa Omiotek, Michael Ryder, James Madara, Bernard Hengesbaugh, Sara Dibari, Martin Paulus, John Touros, Helena Chmura Kraemer, Palo Alto, Howard Bauchner
Journal: JAMA Psychiatry (2018)
The Common Cold
Authors: Robert S. Gohd
Journal: New England Journal of Medicine (1954)

Resistance and SusceptibilityThe factors that determine the resistance and susceptibility to infection with the cold virus are virtually unknown. The low percentage of "takes" in experimental studies on human volunteers has indicated that at any one time approximately half the normal population was resistant to the cold virus. Dochez et al.7 reported an attack rate of 44 per cent in their experiments. The cold virus employed by Feller and his associates12 was characterized by an attack rate of 60 per cent. Andrewes and his co-workers27 believe that the resistance of the population may vary from year to year. At . . .
Radio-frequency electrophrenic respiration. Long-term application to a patient with primary hypoventilation
Authors: J. P. Judson
Journal: JAMA (1968)

Radio-frequency electrophrenic respiration (EPR) has been used successfully on a long-term intermittent basis to manage a patient with primary hypoventilation. The ability to use it only when desired, to adjust the amplitude of stimulation, and to control the rate of stimulation externally, has been made possible by use of the technique of radio-frequency transmission. Electrophrenic respiration by stimulation of one phrenic nerve has been carried out each night for ten months. Moderate fatigue of the stimulated diaghragm could be demonstrated after ten hours of stimulation. Further observation is required to determine if such fatigue is progressive. The future uses of radio-frequency electrophrenic respiration may include any condition of hypoventilation associated with an intact phrenic nerve and diaphragm. Whether its use will be of long-term benefit in the early stages of some hypoventilatory situations secondary to parenchymal disease is under study.
Deaths
Journal: JAMA (1974)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal