tbuckley/cabot-search huggingface dataset:
Continuing education courses for physicians. For the period Sept 1, 1981, through Aug 31, 1982
Journal: JAMA (1981)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Women Smokers and Sudden Death
Authors: David M. Spain
Journal: JAMA (1973)

A retrospective autopsy study was made of the smoking habits of women who died suddenly and unexpectedly of a first clinical episode of coronary heart disease (CHD). A close correlation between heavy cigarette smoking and sudden CHD deaths was found. In the sudden deaths from causes other than CHD, only 28% of the women were heavy smokers, whereas in the CHD sudden deaths there were 62%. The mean age at the time of sudden death was 19 years less for those who smoked cigarettes heavily than for the nonsmokers, while the mean age at death for lighter smokers was intermediate. During the period 1949 to 1959, there were 12 CHD sudden deaths in men for every similar death in women. In contrast, there were only four CHD sudden deaths in men for every similar death in 1967 through 1971 among women. This shift has been associated with an increase in heavy cigarette smoking among women.
Emphysematous Cholecystitis: Report of Seven Cases
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Chemoprevention by Inducers of Carcinogen Detoxication Enzymes
Authors: Thomas W. Kensler
Journal: Environmental Health Perspectives (1997)

One of the major mechanisms of chemical protection against carcinogenesis, mutagenesis, and other forms of toxicity mediated by electrophiles is the induction of enzymes involved in their metabolism, particularly phase 2 enzymes such as glutathione S-transferases (GSTs), uridine diphosphate-glucuronosyltransferases, and NAD(P)H:quinone reductase.Furthermore, induction of phase 2 enzymes appears to be a sufficient condition for obtaining chemoprevention and can be achieved in many target tissues by administering any of a diverse array of naturally occurring and synthetic chemical agents.One class of chemopreventive agents, 1,2-dithiole-3-thiones, was developed on the basis of their potent activity in rodent tissues as inducers of GSTs.A substituted dithiolethione, oltipraz 14-methyl-5-(2-pyrazinyl)-1,2-dithiole-3-thionel, is an effective inhibitor of aflatoxin Bl-mediated hepatocarcinogenesis in the rat.Oltipraz produces dramatic decreases in the levels of aflatoxin-DNA adducts in the liver as well as in the urinary levels of the depurination product aflatoxin-N7-guanine.Corresponding increases are seen in the biliary elimination of aflatoxin-glutathione conjugates.Administration of oltipraz results in 3-to 4-fold increases in hepatic cytosolic GST activities and mRNA levels for some x, p and X isoforms.Nuclear run-on assays have indicated that oltipraz treatment elevates rates of transcription of some GST subunits.In the rat, induction of phase 2 enzymes by oltipraz is mediated, at least in part, through the antioxidant response element in the 5' flanking region of these genes.Although oltipraz has a very short plasma half-life, elevations in the levels of some GST isoforms can persist up to 1 week after dosing with oltipraz.Concordantly, intermittent dosing schedules (i.e., once a week) are nearly as effective as daily interventions for inhibition of aflatoxin-mediated hepatic tumorigenesis.The protective efficacy of daily and weekly administration of oltipraz to people in Qidong, People's Republic of China, who are at high risk for aflatoxin exposure and subsequent development of hepatocellular carcinoma, is currently under evaluation.
The double helix—Watson &amp;amp; Crick's 'freak find' of how like begets like
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lessons from 43 infants with Netherton syndrome
Journal: British Journal of Dermatology (2021)

Netherton syndrome is a genetic condition affecting about five people per million.It appears at or soon after birth with skin rash, unusual hair, allergy and abnormal immunity.Affected babies may become very ill, but severity varies and most dermatologists see only a few cases.Doctors from a specialist referral centre in Paris reviewed cases seen over 38 years to try to put together some guidelines.Of 43 babies with Netherton syndrome, half suffered dehydration with high sodium levels in their blood.Two-thirds were underweight, a quarter had cow's milk allergy and a quarter had diarrhoea.Infections were common: two-thirds had skin infections, others had lung, catheter, kidney or heart infections and 42% developed septicaemia (blood infection).Some unusual hormone problems occurred.Four babies died in the first 9 months, usually with infection but three also had very high sodium levels.The typical rash and hair changes may not be apparent early on.A suspected diagnosis of Netherton syndrome may be confirmed by absence of a key component called LEKTI in a skin biopsy (where a small section of the skin is removed for testing) and by changes (mutations) in the SPINK5 gene in blood.Babies with one particular mutation were more severely affected.Because of the risk of serious infection, careful hygiene measures are advised especially during the first months of life.Excessive protein and fluid are lost through damaged skin and bowel so babies with Netherton syndrome need almost double quantities of fluid and increased amounts of protein and calories.The authors call for expert multidisciplinary care in specialist units.
Hundreds of Eye Infections Linked With Ophthalmology Clinics
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The role of the microbiome in psoriasis: moving from disease description to treatment prediction?
Authors: E.A. Langan, C.E.M. Griffiths, W. Solbach, J.K. Knobloch, D. Zillikens, D. Thaҫi
Journal: British Journal of Dermatology (2018)

Human skin is awash with microbes. It has been estimated that there are up to 2 million organisms, mainly bacteria, in each square centimetre of skin. Until now our understanding of the complexity of this cutaneous (skin) “microbiome” has been limited by traditional laboratory culture methods. Recent advances in molecular techniques have revealed that these older methods may have only detected about 10% of organisms living on the skin. The true state of affairs is vastly more complex. This collaborative paper between scientists in Germany and the UK reviews recent literature in this area of research. Much of the work has been done using a molecular technique called 16S ribosomal RNA sequencing. This permits the detection of the molecular signature of a bacterium, undetectable using traditional culture techniques. It is clear that the pattern of bacteria resident in the skin is influenced by many factors such as anatomical site, patient factors such as age and sex, the presence of skin disease and genetic factors. The role of the “microbiome” in psoriasis is now under scrutiny. Some organisms are prevalent in uninvolved (i.e. symptom‐free) skin but reduced in psoriasis lesions (patches that are affected by psoriasis), whereas Streptococci are more numerous in psoriasis plaques. The role of Streptococcal throat infections in exacerbating psoriasis has long been recognised. It is reasonable to speculate that the interaction between this organism and the host immune system is playing a role in affecting disease activity. It is also possible that studying a patient's “psoriatic microbiome” signature may help scientists to predict their response to treatment.
Family Patterning and Childhood Disorders
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SOME POINTS OF INTEREST TO THE MEDICAL PROFESSION IN THE REPORT OF THE COMMISSIONER OF EDUCATION FOR THE YEAR 1894-95.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Gastric Radiation
Authors: Harold C. Klein
Journal: JAMA (1961)

<h3>To the Editor:—</h3> Words of caution in regard to the hazards of radiation for both malignant and nonmalignant disease have often been spoken. Radiation for ulcer, as outlined in our report, must, of necessity, be administered by a radiotherapist, who should be well versed in the possible sequelae of his method. As for the documented experience in this form of treatment, we refer to the article of Drs. Kirsner and Palmer on treatment of peptic ulcer (<i>Amer J Med</i><b>29</b>:793-803 [Nov.] 1960) in which they report on a total of 1,755 patients treated by gastric radiation since 1937. In our bibliography, we referred to the article by Drs. Levin, Clayman, Palmer, and Kirsner, which is a similar report on a portion of the same group noted above. In my own experience (Dr. Berman) there has been a total of 310 cases of duodenal ulcer treated by radiation since January,
Catheter migration during home hyperalimentation
Authors: J. L. Mullen
Journal: JAMA (1977)

SILASTIC catheters for long-term central venous angio-access have contributed to the efficacy of home hyperalimentation. They have decided advantages over conventional polyethylene and polyvinyl catheters, including flexibility without kinking, minimal thrombogenicity, and few septic complications.<sup>1</sup> Our case report details the migration of a Silastic catheter after long-term permanent implantation, its clinical sequelae, and necessary therapeutic maneuvers. <h3>Report of a Case</h3> A 23-year-old man was admitted from another hospital after initial treatment for gangrenous midgut volvulus secondary to malrotation of the colon. After resolution of numerous complications, intestinal continuity was reestablished with a duodenocolostomy. Long-term home hyperalimentation was instituted after placement of a permanent Broviac Silastic subclavian catheter via the right cephalic vein. Catheter position in the right atrium was confirmed postoperatively by x-ray examination. After five months of asymptomatic, uneventful home parenteral nutrition, the patient noted the gradual onset of right-sided cervical and suprascapular pain, consistently accentuated by the
Toward fewer procedures and better outcomes
Authors: S. C. Schoenbaum
Journal: JAMA (1993)

In 1987 and 1988 the Health Program at RAND, Santa Monica, Calif, published a series of articles on the appropriateness of various medical procedures that had been performed between 1979 and 1982.<sup>1-3</sup>The RAND investigators had developed appropriateness criteria by a specific method in which panels of nine experts reviewed relevant medical literature and then rated a series of clinical scenarios (indications). When the criteria sets were applied to actual patient records, it appeared that a significant percentage of the procedures were unnecessary. The medical and general public pounced on these reports. At last there was evidence that substantial savings might be achieved in health care; and since the savings would derive from the elimination of unnecessary care, there should actually be a concomitant increase in the quality of care. See also pp 753, 761, and 766. In this issue ofThe Journalthere are three more articles<sup>4-6</sup>
Some skeptics become oxygen therapy 'converts'
Journal: JAMA (1981)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cardiovascular responses of hyperactive children to methylphenidate
Authors: J. E. Ballard
Journal: JAMA (1976)

Heart rate, blood pressure, and oxygen consumption were measured in 27 hyperactive children during rest, exercise, and recovery, once taking placebo and again taking methylphenidate hydrochloride. Half were measured first taking the drug and half first taking the placebo. Twenty-three matched controls were also measured twice to test for reproducibility of results. Drug and placebo ECGs were recorded on 12 of the subjects. Oxygen consumption did not change (<i>P</i>=.40), but heart rate (<i>P</i>=.001) and blood pressure (<i>P</i>=.003) increased significantly with methylphenidate therapy. There was a significant correlation between size of dose in milligrams per kilogram and increase in heart rate (.38,<i>P</i>&lt;.05) and blood pressure (.50,<i>P</i>&lt;.05 systolic) (.46,<i>P</i>&lt;.05 diastolic). No evidence of the development of tolerance to these drug effects was found in children who had been taking methylphenidate from two months to more than a year. No ECG changes other than tachycardia were seen. (<i>JAMA</i>236:2870-2874, 1976)
Femur fractures are associated with high morbimortality in patients with cirrhosis
Authors: Anna Brujats, Laura Gonzalez Gonzalez, Mireia Trias, Roger Rojas, Berta Cuyas, Edilmar Alvarado, Eva Roman, Julio De Caso, Carlos Guarner, German Soriano, Maria Poca
Journal: Journal of Hepatology (2020)
COPPER IN NUTRITION
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal