tbuckley/cabot-search huggingface dataset:
Cancer Medicine
Authors: Jacob D. Bitran
Journal: JAMA (1997)

Textbooks in any field are by definition authoritative and represent a standard in a subject area. In addition, medical textbooks have to serve a diverse readership—from students to practicing, experienced physicians. Editors of clinical oncology texts have the additional burden of attempting to provide a standard in an area that changes and evolves almost yearly, lest these texts become outdated at the time of publication. The editors of the fourth edition of<i>Cancer Medicine</i>offer a textbook that, like clinical oncology itself, has evolved since the first edition.<i>Cancer Medicine</i>is an excellent text, authoritative and well organized, with 324 contributors. The first of three sections provides chapters on cancer biology, tumor immunology, and etiology, including practice of clinical trials, prevention, and screening and early detection, and a new chapter on carcinogenesis from low-frequency electromagnetic fields. The second section covers the principles of cancer therapy and includes two new
Omenn Syndrome is Associated with Mutations in DNA Ligase IV
Authors: V.H.D. Kim, E. Grunebaum, A. Bates, C.M. Roifman
Journal: Journal of Allergy and Clinical Immunology (2009)

RATIONALE: Omenn syndrome (OS) is a variant of severe combined immunodeficiency (SCID) that is fatal unless treated with allogeneic bone marrow transplant (BMT). We report the first case of a patient with mutations in DNA Ligase IV gene who presented with typical clinical and laboratory features of OS, which was corrected after allogeneic BMT. METHODS: A review of a case of OS and analysis of DNA Ligase IV gene. RESULTS: A 3 week old female born to non-consanguineous parents presented with protracted erythroderma, hepatosplenomegaly, generalized lymphadenopathy and diarrhea. Evaluation of the immune system revealed markedly elevated eosinophils, low CD3 + T cells, markedly reduced T cell response to mitogen stimulation and markedly reduced T cell receptor excision circles (TREC). Analysis of T cell receptor (TCR) V beta families showed excessive expansion of 3 TCR families and underrepresentation of most other families. B cells were nearly absent and serum IgA and IgM levels were reduced. Sequencing of DNA Ligase IV gene revealed 3 heterozygous mutations, including a novel deletion. At 6 months of age, the patient received an HLA-matched unrelated donor BMT following myeloablative conditioning with busulphan and cyclophosphamide. At 3.5 years after transplant, the patient continues to demonstrate complete donor chimerism, and T and B cell numbers, T cell responses to mitogens, TREC, immunoglobulin production and TCR repertoire were all normal. CONCLUSIONS: Patients with mutations in DNA Ligase IV can present with features of OS. BMT with full myeloablative conditioning can be effectively and safely used to correct the SCID.
Abstract 3703: Development of oncopig urothelial carcinoma cell lines
Authors: Aisha Qazi, Faith M. Thomas, Sulalita Chaki, Noah Robertson, Shovik Patel, Kyle M. Schachtschneider, Lawrence B. Schook
Journal: Cancer Research (2019)

Abstract Urothelial carcinoma (UC), more commonly known as bladder cancer, affects approximately 81,000 people a year in the United States and is the fourth most common type of cancer among men. Age also plays a tremendous factor, as 90% of people affected by bladder cancer are older than 55, and if the cancer has metastasized the 5-year survival rate is 35%. This requires the advancement of early detection and treatment methods for bladder cancer. The development of clinically relevant systems to serve as a bridge between preclinical murine studies and human clinical practice is of vital importance. The Oncopig Cancer Model (OCM) is a novel transgenic swine platform that recapitulates human cancer through development of site/cell specific tumors after Cre recombinase induced expression of heterozygous KRASG12D and TP53R167H transgene. In this study, we standardized a protocol for the development and growth of Oncopig UC cell lines that faithfully recapitulates in vitro and in vivo features of human bladder cancer. The focus of this preliminary research was to successfully create OCM UC cell lines that mimic features of human UC. OCM urothelial cell lines (n=7) were isolated from whole bladders collected from male Oncopigs at euthanasia. OCM urothelial cell lines were exposed to Cre recombinase 48 hours post isolation to induce expression of KRASG12D and TP53R167H transgenes, resulting in development of OCM UC cell lines. Differences in migration rates were observed between OCM urothelial and UC cell lines, confirming cellular invasiveness. RT-PCR was performed after several passages to confirm KRASG12D and TP53R167H gene expression, which was observed in OCM UC but not urothelial cell lines. Uroplakin II and pan-Cytokeratin (PCK-26) are markers for UC and urothelial cells, respectively, and are used to diagnose UC clinically. OCM UC cells stained positively for Uroplakin II and PCK-26, confirming their identity as malignant UC cells. Future work is needed to confirm OCM and human UC display similar histological and molecular features, and to develop strategies for in vivo OCM UC tumor development. Citation Format: Aisha Qazi, Faith M. Thomas, Sulalita Chaki, Noah Robertson, Shovik Patel, Kyle M. Schachtschneider, Lawrence B. Schook. Development of oncopig urothelial carcinoma cell lines [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3703.
Illustrations of Exceptional Symptoms and Examples of Rare Forms of Disease
Authors: J. Hutchinson
Journal: BMJ (1886)

OF SKULL.IN'the case of a little boy, whom I saw at the Poplar Hospital, and who was a patient of Mr. Corner's, the symptom of brachioplegia was of much interest.He was an intelligent little fellow, 7 years old.Riding behind a carriage, his head had become engaged in the spokes of the wheel, and much battered.When taken into the hospital, he was quite sensible.There were bleeding from his right ear, and considerable bruising of the scalp, especially on the right side, where there seemed to be some irregularity of bone.He complained that he could not use his arms well, especially the right.During the next few days, large ecehymoses appeared on the conjunctiva of each eyeball, and the weakness of the arms increased.The accident occurred on October 16th.A fortnight after it, Mr. Archibald An- drews, the house-surgeon in charge, in writing to ask me to come and see the patient, stated that both arms were quite helpless, lying in a semiflexed condition.The action of the biceps, he added, was perfect.It was more than three weeks after -the accident, and a week afte'r Mr Andrew's note, when I saw the boy.He had been carefully kept in
Determination of Total Arsenic in Environmental Samples from Kumasi and Obuasi, Ghana
Authors: Eugene H. Amonoo-Neizer, Emmanuel M. K. Amekor
Journal: Environmental Health Perspectives (1993)

The total arsenic content of some Ghana food and cash crops from Kumasi and Obuasi farms and markets was determined. Quantitative analysis of arsenic was also conducted on vegetation, cooked food obtained from some homes, local fish, and meat, as well as some soil and water samples. In all, 266 samples were examined. Values for Kumasi samples ranged from 0.07 to 7.20 mg/kg arsenic, whereas those for Obuasi ranged from 0.12 to 70.50 mg/kg, confirming that arsenic levels for Obuasi are much higher than those for Kumasi.
Annals of Allergy, Boston
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE SOLDIERS' FEET AND FOOTGEAR
Authors: C. Webb-Johnson
Journal: BMJ (1914)

Al. Delorimie, tlle Frenchy army surgeon, lhas-reported this class of injury to have occurred wheni only strolng ten(linotus soft parts lhad been -traversed by the bullet, but in tlle experimenits, anid as actuially ex- perieniced in Soutlh Africa, the implication of com-pact bone in the bullet track is necessary for their production in tllcir really typical clharacter.Injuries of this class were caused by tlle Snider and Martini-Henry bullets of as grcat severity as those resulting from small-bore bullets, but not so frequenitly, because the former did not retain a sufficienitly higlh velocity over as long ranges as the latter.The older buillets prodtuced them-n up to 100 or 150 yards' -ange, wlhereas the Lee-Enfield, Lebel, and Mauser bullets produced thenl up to about 400 yards.The cause of the great destructive effect seen on the exit side is the violent (lisplacement,of the fragments representing the comminu- tion wllich occurs in thle compact bone tissue, due to the
Puerperal Scarlatina
Authors: V. Stone
Journal: BMJ (1878)

THA BR-ITIShRMIL OtN 55 below upwards: that is, from the part first affected to that last).There was left in the cornea an universal thick projecting opacity.The conjunctivre were still injected and insensible.The masticatory muscles seemed to be regaining their power.The inferior maxilla could now be moved to a slight extent towards the right side.showing some return of power in the pterygoids.The abrasions on the buccal mucous membrane were healing, as also the sponginess of the gums.Zearing was i;mraz'ed.The patient took her discharge on May gth, contrary to the advice of the 'medical officer, and much to my annoyance.I think it by no means improbable, had she remained in hospital, that, under the con- tinued use of iodide of potassium, proper hygienic means, and good unstimulating diet, she would have improved still more, if not have been cured altogether; but I fear that, returning to her old habits- and those, I am inclined to think, neither very temperate nor moralher symptoms will retrograde, and possibly at some future date she may be admitted to some hospital in a worse condition than at first.REMARKS.-The case I have just related is one of very great in- terest, and by no means of common occurrence.We could not have a more complete and accurate exposition of the functions and dis- tribution of the trigeminal nerve, as proved by the results of experimental physiology and clinical observation.It shows, in a remarkably clear manner, the influence this nerve exerts, directly or indirectly, over several of the special senses, viz., of vision, hearing, taste, and smell, all these being more or less implicated.
Declining Blood Lead Levels and Cognitive Change in Children
Authors: Robert D. Cunningham
Journal: JAMA (1993)

<h3>To the Editor.</h3> —In study by Ruff et al<sup>1</sup>of the effect of declining lead levels on the cognitive abilities of children, some children in the study sample were found to be developmentally delayed during testing performed at the time of entrance into the study. And an even larger number of children were found to be in the range where they might be described as being at "high risk" for developmental delay. Perhaps the majority of children in this study were of the age range, socioeconomic status, and cognitive performance level where they were likely to be eligible for early childhood education programs, and I would suspect that some study children were enrolled in such programs between the time they were enrolled in the lead study and their 6-month follow-up. For those who are enrolled in such childhood enrichment programs, these children are being removed to a more relatively
Abstract 828: Adiponectin Enhanced ApoA-1- and HDL- mediated Cellular Cholesterol Efflux from Human Monocyte-Derived Macrophages
Authors: Masahiro Koseki, Kazumi Tsubakio-Yamamoto, Fumihiko Matsuura, Hiroyuki Oku, Jose C Sandoval, Miyako Yuasa-Kawase, Daisaku Masuda, Makoto Nishida, Masato Ishigami, Ken-ichi Hirano, Shinji Kihara, Masatsugu Hori, Iichiro Shimomura, Shizuya Yamashita
Journal: Circulation (2007)

(Background) Plasma HDL-cholesterol levels are inversely correlated to the risk of CAD. HDL plays a crucial role as a shuttle carrying cholesterol derived from peripheral tissues and transporting it back to the liver. Recently, ATP-binding cassette transporters (ABCA1, ABCG1) have been identified as important membrane receptors to generate HDL by removing cholesterol and phospholipids from macrophage foam cells in the arterial wall. On the other hand, adiponectin (APN) abundantly secreted from adipocytes is one of the important molecules to inhibit the development of atherosclerosis. Epidemiological studies have revealed a positive correlation between plasma HDL-cholesterol and APN concentrations in humans, and APN levels are decreased in patients with CAD. In the current study, we investigated the role of APN on cellular cholesterol efflux from human macrophages. (Methods) Recombinant human APN was prepared. Human monocyte-derived macrophages were isolated from whole blood of healthy volunteers and incubated with RPMI-1640 medium containing 10% type AB serum. After 7 days incubation, the indicated concentrations of recombinant APN were added to the medium containing 0.1% BSA and incubated for 24 hours. The expression of ABCA1 and ABCG1 was measured by real-time quantitative PCR and western blot analyses. Cholesterol efflux from macrophages, previously incubated with [ 3 H]-labeled acetylated LDL, was measured with or without APN and expressed by a percentage of radioactivity of the medium to total radioactivity (cells plus medium). APN was added into the medium containing 0.1% BSA and apoA-1 (10 μg/ml) or HDL (50 μg/ml HDL protein) and incubated for 24 hours. (Results) APN significantly up-regulated the mRNA and protein levels of ABCA1 in human macrophages by 3.6- and 2-fold, respectively. ApoA-1-mediated cholesterol efflux from macrophages was 8.1-fold-increased by APN treatment. Furthermore, the expression of ABCG1 was also significantly increased by APN. HDL-mediated cholesterol efflux was slightly increasd by APN. (Conclusions) In conclusion, APN might act as a protective factor against atherosclerosis by increasing cholesterol efflux from human macrophages in both ABCA1- and ABCG1-dependent pathways.
DISCRIMINATION IN PHYSICAL CULTURE METHODS.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE SIGNIFICANCE OF PATHOLOGIC PROCESSES IN EVOLUTION.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Book in Brief
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 332: A Data Mining Strategy Identifies microRNA-15b-5p as a Potencial Bio-Marker in Non-Ischemic Heart Failure
Authors: Georthan Mancilla, Ingrid Oyarzun, Rocio Artigas, Clara Quiroga, Ignacio Wichmann, Hugo Verdejo, Pablo Castro
Journal: Circulation Research (2017)

Advances in bioinformatics has provided us with large databases that characterize the complex genetic and epigenetic changes associated with human diseases. The use of data mining strategies on public access databases to identify previously unknown disease markers is an innovative approach to identify potential biomarkers or even new therapeutic targets in complex diseases such as heart failure (HF). We assessed the hypothesis that a bioinformatic strategy of meta-analysis using existing public databases may predict novel differentially expressed microRNA (miR) in non-ischemic HF patients.We systematically reviewed the literature for miR profiling and HF (2006-2014). Four studies fulfilled quality criteria for analysis. Raw data from the largest study (discovery dataset, n=35) was normalized and analyzed by unsupervised hierarchical clustering. Significance analysis selected miRs with a fold change of 2 and a false discovery rate of less that 1%. The miRs reported as significant in the other three papers were incorporated in a meta-analysis using a robust rank aggregator approach and then contrasted with the results of the unsupervised analysis of raw data. To validate the in-silico analysis, we evaluated the miRs with higher predicted fold change in plasma samples from 23 patients with HF and five healthy controls using RT-qPCR. Internal controls included miR-39 for standardization of the extraction procedures and miR23a, miR451 as hemolysis markers. Results: The in-silico strategy identified 54 miR that fulfilled our criteria. The meta-analysis confirmed nine differentially expressed miRs, six of them previously reported (let-7b, miR-100, miR-103, miR-199a, miR-23a) and three with no known relation with HF (miR-125b, miR-140, miR-15b). RT-qPCR of HF plasma samples revealed that miR-15b-5p was significantly reduced in HF subjects (p=0.004). Conversely, the previously described miR-23a (p = 0.0021) and let-7b (p = 0.0195) were largely increased in HF subjects. In conclusion, bioinformatics analysis allows the identification of previously unreported miR associated with HF. This novel approach using publicly available data for the identification of new potential biomarkers may accelerated the pre-analytic phase of biomarker research.
AMA annual convention 1978
Authors: W. R. Barclay
Journal: JAMA (1978)

Sufficient time has now passed that we can view the annual meeting of the American Medical Association held in St Louis June 18 through 22 in a detached and objective manner. Two notable features will give this meeting historical importance and make it a point of reference for years to come; it was the last of a traditional format in which a scientific session was held conjointly with the meeting of the House of Delegates, and the House gave its major attention to the problem of controlling the rising costs of medical care. The matter of divorcing the scientific session from the meeting of the House is of no small importance and should be subject to periodic review. Science has always been very much the business of the AMA, and physicians like to think of themselves as scientists first and as all other descriptors, including politicians, second. Although most of
Possibility of potential VWD misdiagnosis or misclassification using LIA technology and due to presence of rheumatoid factor
Authors: Emmanuel J. Favaloro, Margaret Aboud, Chris Arthur
Journal: American Journal of Hematology (2001)

von Willebrand's disease (VWD) is now recognised to be the most common inherited bleeding disorder and is due to defects and/or deficiencies in von Willebrand factor (VWF). The latex immuno-assay (LIA) procedure has become a popular VWF:Ag detection methodology because of the ability to automate testing. In this report, we present findings which urge caution when normal LIA results are obtained co-incident to striking clinical findings strongly suggestive of VWD, or previous laboratory findings consistent with VWD. As illustrated by a relevant case study, normal LIA results may lead to an “incorrect diagnosis” of “not VWD” or to a potential subtype misdiagnosis, should they be accepted without cross-confirmation using alternative VWF methodologies. Am. J. Hematol. 66:53–56, 2001. © 2001 Wiley-Liss, Inc.