tbuckley/cabot-search huggingface dataset:
IMPACT OF CHRONIC KIDNEY DISEASE ON CARDIOVASCULAR EVENTS IN PATIENTS UNDERGOING PERCUTANEOUS CORONARY INTERVENTION WITH EVEROLIMUS-ELUTING STENT: RISK STRATIFICATION WITH C-REACTIVE PROTEIN
Authors: Kazuhiro Dan, Makoto Nakahama, Toru Miyoshi, Hiroshi Ito
Journal: Journal of the American College of Cardiology (2018)
MEDICAL REFLECTIONS ON THE TYNDALL CENTENARY
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Software
Authors: David L. Horwitz
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Treatment patterns and outcomes of acneiform eruptions from anti-epidermal growth factor receptor (EGFR) therapies for metastatic colorectal cancer (MCRC).
Authors: Bogdan Dascalu, Hagen F. Kennecke, Howard John Lim, Winson Y. Cheung
Journal: Journal of Clinical Oncology (2012)

668 Background: Use of anti-EGFR therapies, such as cetuximab (cmab) and panitumumab (pmab), is associated with acneiform eruptions. Because prior research suggests a possible correlation between rash severity and outcomes in unselected patients, concerns remain that prophylactic treatment of rash may interfere with anti-tumor activities of these drugs. Our aims were to: 1) characterize the treatment patterns for rashes due to cmab and pmab; and 2) evaluate if a prophylactic vs. reactive approach to rash management modifies outcomes. Methods: All patients diagnosed with wild-type K-ras MCRC from July 2009 to June 2011 in British Columbia, Canada and prescribed either cmab or pmab were identified. We conducted a detailed retrospective review to describe prophylactic (before rash) and reactive (after rash) use of antibiotics and steroid creams. Using Cox regression, the relationship between rash management and overall survival was characterized. Results: In total, 78 eligible patients were analyzed: median age was 62 years, 65% were male, 27% received cmab and 73% pmab, and median number of anti-EGFR treatment was 9 cycles. Rash occurred in 88% of patients. Among them, reactive treatment was favored over prophylactic treatment (74% vs. 26%). There were no differences in rash management based on any patient or tumor characteristics (all p&gt;0.05). Median overall survival was 7.2 months. The number of treatment cycles and overall survival were similar in both prophylactic and reactive groups. In Cox regression, ECOG 2+ correlated with worse overall survival (HR for death 5.95, 95% CI 1.68- 21.13). However, outcomes were statistically similar between patients prescribed antibiotics prophylactically vs. reactively (HR=1.47, 95% CI 0.37-5.90) and between patients given steroid creams prophylactically vs. reactively (HR=0.75, 95% CI 0.11-4.88). Conclusions: Prophylactic treatment of anti-EGFR related rash is associated with similar outcomes as reactive rash treatment in wild-type K-ras MCRC patients. Because rash can lead to decreased quality of life, pre-emptive skin treatment represents a reasonable strategy for patients on anti-EGFR therapies.
SUPRARENAL FUNCTIONS
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Overview of a System for the Computer-Assisted Operation of a Small Animal Inhalation Facility
Authors: Ethard W. Van Stee, Michael P. Moorman
Journal: Environmental Health Perspectives (1984)

Automatic monitoring of the concentration of test gases and other environmental variables in small animal inhalation exposure chambers, coupled with computing capa- bility and feedback control of the concentration of test gas, allows almost fully automatic operation of the chambers with a minimal amount of human intervention.Time-varying exposure profiles may be generated repeatedly with great accuracy, thus allowing a more realistic simulation of real-life exposures than is approached by operating chambers manually at ostensibly constant concentrations of test gases.Carefully conducted, preexperimental calibration procedures are performed, and daily calibration checks allow statistical control of daily chamber operation and longer term quality control.At the conclusion of each experiment the investigator is supplied with records that document chamber conditions that have been monitored throughout the entire experiment, with estimates of the accuracy that was achieved in creating the specified exposure proffle.A purpose of this report is to help to bridge the gap between the practicing inhalation toxicologist and the engineer in order to encourage their cooperation and mutual under- standing of the technical problems involved in developing computer-assistance packages for inhalation facilities.
Peritoneal dialysis in quinine sulfate intoxication
Authors: T. N. Markham
Journal: JAMA (1967)

Early cinchonism developed in an 18-year-old girl after the ingestion of 3.84 gm of quinine sulfate, in an attempt to induce abortion. Initially, the exact dose was unknown and she was treated with peritoneal dialysis. Although dialysis was begun after the peak plasma levels had passed, 415 mg (10.8%) were recovered in the dialysate fluid over the next 16 hours.
A Manual of Bandaging, Strapping and Splinting
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
No public health without migrant health
Authors: None The Lancet Public Health
Journal: The Lancet Public Health (2018)

1 billion people in the world today are on the move. There are an estimated 244 million international migrants (3·3% of the world's population)—an increase from 155 million in 2000. Internal migration is most prevalent, with more than 740 million people who have migrated within their own country of birth. According to the International Organisation for Migration (IOM), the UN migration agency, we are facing the highest levels of forced displacement globally recorded since World War 2, with a dramatic increase in the number of refugees, asylum-seekers, and internally displaced people across various regions of the world.
Identification of Optimal Conditions for Lung Graft Storage With Euro-Collins Solution by Use of a Rat Orthotopic Lung Transplant Model
Authors: Koichi Kayano, Koichi Toda, Yoshifumi Naka, David J. Pinsky
Journal: Circulation (1999)

Background —Lung preservation disrupts normal vascular homeostasis, resulting in increased permeability, vasoconstriction, and endothelial cell adhesion for neutrophils. We hypothesized that a storage strategy that best preserves post–lung transplantation (LTX) vascular homeostasis might be organ and species specific. Because of the potential utility of a rat LTX model for developing improved lung preservation strategies, we have attempted to identify the optimal physical conditions for rat lung graft storage. Methods and Results —Conditions that were tested included harvest inflation pressure (0, 10, or 20 mm Hg), inflation gas composition (100% N 2 , room air, or 100% O 2 ), and storage temperature (4°, 10°, or 15°C). Modified Euro-Collins solution served as the base preservation solution for all experiments, with a preservation duration of 4 to 6 hours. Arterial oxygenation (Pa o 2 , mm Hg), pulmonary vascular resistance (mm Hg/mL per minute), recipient survival (%), and graft neutrophil infiltration (ΔAbs 460 nm /min) were measured 30 minutes after transplantation of the left lung and exclusion of the right lung from the circulation. All tested conditions significantly affect post-LTX vascular homeostasis. Inflation at 10 mm Hg pressure preserved lungs significantly better than did other pressures. There was a tendency for room air to improve all measured variables compared with 100% N 2 or 100% O 2 and a significant improvement in recipient survival with room air storage. Of the 3 storage temperatures investigated, 10°C storage provided the best preservation in terms of Pa o 2 , graft neutrophil infiltration, and survival. Conclusions —We conclude that storage at 10°C, 10 mm Hg inflation pressure, with room air establishes optimal lung storage conditions with Euro-Collins solution in this rat LTX model. These data suggest that these conditions should be used to evaluate new and potentially improved preservation strategies.
Abstract 712: Down-regulation and nuclear localization of survivin by sodium butyrate induces caspase-dependent apoptosis in human oral mucoepidermoid carcinoma
Authors: Chi Hyun Ahn, Sung-Dae Cho
Journal: Cancer Research (2019)

Abstract Sodium butyrate (NaBu) is a histone deacetylase inhibitor that possess an apoptotic ability. However, the molecular mechanism by which NaBu induces apoptosis in human oral mucoepidermoid carcinoma (MEC), a type of salivary gland tumor, remains unclear. The anticancer effects of NaBu and its related molecular mechanisms were determined by trypan blue exclusion assay, 4'-6-diamidino-2-phenylindole staining, live/dead assay, human apoptosis array, RT-PCR, western blotting, immunocytochemistry, preparation of nuclear fractions, and nude mice tumor xenograft. In this study, we found that NaBu inhibited growth and induced apoptosis in the human oral MEC cell lines MC3 and YD15 with the acetylation of histone proteins H2A and H3. NaBu apparently down-regulated survivin protein, as evidenced by the results of the human apoptosis antibody array, and modulated it at the post-translational process. Interestingly, NaBu caused nuclear translocation of survivin protein in both cell lines. NaBu also resulted in decreased expression levels of Bcl-xL mRNA and protein, leading to induction of caspase-dependent apoptosis in human oral MEC cell lines. In addition, NaBu administration inhibited tumor growth in vivo at a dosage of 500 mg/kg/day, but it did not cause any hepatic or renal toxicity. This study provides new insights into the molecular mechanism of apoptotic actions by NaBu in human oral MEC and the basis of its clinical application for the treatment of human oral MEC. Citation Format: Chi Hyun Ahn, Sung-Dae Cho. Down-regulation and nuclear localization of survivin by sodium butyrate induces caspase-dependent apoptosis in human oral mucoepidermoid carcinoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 712.
Guides to the evaluation OF PERMANENT IMPAIRMENT. The endocrine system
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Institute of Medicine panel suggests changes to revitalize National Institutes of Health
Authors: C. Marwick
Journal: JAMA (1989)

IF THE INTRAMURAL research program at the National Institutes of Health (NIH), Bethesda, Md, is to continue to attract high-quality scientists and retain leadership in biomedical research, changes need to be made. This is the message delivered by an Institute of Medicine (Washington, DC) committee that was asked to look into the program. The committee, chaired by Harold T. Shapiro, PhD, president of Princeton (NJ) University, urged both Congress and the administration to act. <h3>The Next Step</h3> Having pronounced the dire warnings, the next step is to get at least some of the recommendations implemented. "We're having a dialogue with the staff at the Office of Management and Budget," says the Institute of Medicine's president, Samuel Thier, MD. With a current budget of $700 million, only 11% of the total NIH budget, the intramural program is small by Washington standards. But its facilities include the clinical center where researchers and
The presence and accessibility of firearms in the homes of adolescent suicides. A case-control study
Authors: D. A. Brent
Journal: JAMA (1991)

<h3>Objective.</h3> —The presence of guns in the home, the type of gun, and the method of storage were all hypothesized to be associated with risk for adolescent suicide. <h3>Design.</h3> —Case-control study. <h3>Subjects.</h3> —The case group consisted of 47 adolescent suicide victims. The two psychiatric inpatient control groups were 47 suicide attempters and 47 never-suicidal psychiatric controls, frequency-matched to the suicide victims on age, gender, and county of origin. <h3>Setting.</h3> —The cases were a consecutive community sample, whereas the inpatients were drawn from a university psychiatric hospital. <h3>Main Outcome Measure.</h3> —Odds of the presence of guns in the home of suicide victims (cases) relative to controls. <h3>Results.</h3> —Guns were twice as likely to be found in the homes of suicide victims as in the homes of attempters (adjusted odds ratio, 2.1; 95% confidence interval, 1.2 to 3.7) or psychiatric controls (adjusted odds ratio, 2.2; 95% confidence interval, 1.4 to 3.5). Handguns were not associated with suicide to any statistically significantly greater extent than long guns. There was no difference in the methods of storage of firearms among the three groups, so that even guns stored locked, or separate from ammunition, were associated with suicide by firearms. <h3>Conclusions.</h3> —The availability of guns in the home, independent of firearms type or method of storage, appears to increase the risk for suicide among adolescents. Physicians should make a clear and firm recommendation that firearms be removed from the homes of adolescents judged to be at suicidal risk. (<i>JAMA</i>. 1991;266:2989-2995)
Therapeutic abortion law confusion
Authors: J. M. Kummer
Journal: JAMA (1966)

The problems relating to criminal abortion are of utmost complexity from social, medical, and legal viewpoints. Airing these problems is deemed prerequisite to any attempt at solution, and clarifying therapeutic abortion laws, to bring them into conformity with responsible medical attitudes and practices, is a significant primary step in clearing the atmosphere of the extreme confusion surrounding the matter of abortion in general and of therapeutic abortion in particular. While the laws of abortion in the United States and most of the western world profess primarily to safeguard the prospective mother, by their uncompromising severity they drive large numbers of desperate women into the hands of the unskilled abortionist, the very person from whom society seeks to shield them. <h3>Abortion in the United States</h3> In our country, it is apparent that abortion is a definite part of our social mores, with society steadfastly refusing to acknowledge this to be so.
Identifying Chemical Carcinogens and Assessing Potential Risk in Short-Term Bioassays Using Transgenic Mouse Models
Authors: Raymond W. Tennant, John E. French, Judson W. Spalding
Journal: Environmental Health Perspectives (1995)

Cancer is a worldwide public health concern. Identifying carcinogens and limiting their exposure is one approach to the problem of reducing risk. Currently, epidemiology and rodent bioassays are the means by which putative human carcinogens are identified. Both methods have intrinsic limitations: they are slow and expensive processes with many uncertainties. The development of methods to modify specific genes in the mammalian genome has provided promising new tools for identifying carcinogens and characterizing risk. Transgenic mice may provide advantages in shortening the time required for bioassays and improving the accuracy of carcinogen identification; transgenic mice might now be included in the testing armamentarium without abandoning the two-year bioassay, the current standard. We show that mutagenic carcinogens can be identified with increased sensitivity and specificity using hemizygous p53 mice in which one allele of the p53 gene has been inactivated. Furthermore, the TG.AC transgenic model, carrying a v-Ha-ras construct, has developed papillomas and malignant tumors in response to a number of mutagenic and nonmutagenic carcinogens and tumor promoters, but not to noncarcinogens. We present a decision-tree approach that permits, at modest extra cost, the testing of more chemicals with improved ability to extrapolate from rodents to humans.
Highlights
Journal: JAMA Psychiatry (2019)

Efficacy of Adjunctive Infliximab for Bipolar Depression 783Despite evidence for immuno-inflammatory activation in bipolar depression, no study has assessed the antidepressant efficacy of infliximab, a monoclonal antibody targeting tumor necrosis factor among patients with this activation.McIntyre and colleagues randomized 60 patients with bipolar depression to 3 adjunctive intravenous infusions of infliximab vs placebo in double-blind fashion and found that infliximab did not significantly reduce depressive symptoms at 12 weeks despite patients having biochemical and/or phenotypic evidence of inflammatory activation.In an Editorial, Berk et al discuss the state of research on biomarker-guided anti-inflammatory therapies in mood disorders.
JAMA Oncology
Journal: JAMA Oncology (2017)

JAMA Oncology is committed to publishing infl uential original research, opinions, and reviews that advance the science of oncology and improve the clinical care of patients with cancer.Mission Statement JAMA Oncology is the defi nitive journal for scientists, clinicians, and trainees in the fi eld of oncology worldwide.Our original, innovative, and timely scientifi c and educational content provides a deeper understanding of cancer pathogenesis and recent treatment advances for our readers.JAMA Oncology aims to eff ectively convey the fi ndings of important clinical research, major scientifi c breakthroughs, actionable discoveries, and state-of-the-art treatment pathways to the oncology community.Our goal is that successful communication of new knowledge will ultimately translate to clinical benefi t for people living with and surviving cancer.