tbuckley/cabot-search huggingface dataset:
Family
Authors: Arifeen S. Rahman
Journal: Annals of Internal Medicine (2019)

On Being a Doctor2 July 2019FamilyArifeen S. Rahman, ABArifeen S. Rahman, ABStanford University School of Medicine, Stanford, California (A.S.R.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M19-0395 Audio Reading - “Family” Audio. Michael A. Lacombe, MD, Annals Associate Editor, reads “Family” by Arifeen S. Rahman, AB Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail We sat in a row like ducks, dressed in white coats, facing the patient and his family. The no man's land between us was the physical and metaphorical space that separated patient from provider.At center stage sat the protagonist and patient, a man in his 70s with progressive COPD, clutching his tank of oxygen like a safety blanket. The wife looked frail, stationed at his side and wearing a matching fuchsia cardigan and shoes. The teenage granddaughter gazed at the clock, disinterested, thumbs rapidly tapping on her iPhone X. The adult daughter rifled through color-coded accordion folders of meticulously ... Author, Article, and Disclosure InformationAffiliations: Stanford University School of Medicine, Stanford, California (A.S.R.)Corresponding Author: Arifeen S. Rahman, AB, Stanford University School of Medicine, 291 Campus Drive, Stanford, CA 94305; e-mail, [email protected]edu. PreviousarticleNextarticle Advertisement Audio Reading - “Family” Audio. Michael A. Lacombe, MD, Annals Associate Editor, reads “Family” by Arifeen S. Rahman, AB Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics Cited byReducing Health Care–Associated Infection: Getting Hospitals and Health Systems to ZeroJay Bhatt, DO, MPH and Sue Collier, MSN, RNQualitative Assessment of a State Partner–Facilitated Health Care–Associated Infection Prevention National CollaborativeKaren E. Fowler, MPH, Jane Forman, ScD, Jessica M. Ameling, MPH, Andrew J. Rolle, MPH, Deborah Bohr, MPH, Brittany Schwartz, MPH, Sue Collier, MSN, RN, Vineet Chopra, MD, MSc, and Jennifer Meddings, MD, MSc 2 July 2019Volume 171, Issue 1Page: 66-67KeywordsEmotionsFearGastrectomyGastric cancerIntensive care unitsMemoryMotivationNutritionOxygenSafety ePublished: 2 July 2019 Issue Published: 2 July 2019 Copyright & PermissionsCopyright © 2019 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Neurological Disease in Boxers
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
European Perspectives
Journal: Circulation (2011)

Ever since then, he has been interested in manipulating the cardiac workload of the failing heart.He has been at the forefront of implementing new therapies for heart failure in Italy, including β-blocker therapy, transplantation, left ventricular assist devices, and resynchronisation therapy.He is now working on a new implantable device to modulate sympathetic activity in heart failure patients by stimulating the carotid glomus, and he is setting up a resynchronisation therapy and β-blocker titration project to assess the outcome of heart failure based on a patient's tolerance of βblocker therapy. "After Careful Reassessment of the Drug Uptitration Approach, We Achieved Significant Results Using β-Blockers in Selected Patients"Born in Milan, Italy, in 1951, Dr Gronda was influenced from an early age by a relative, who was a psychiatrist with On other pages... a unique skill in interacting with suffering people, and by 1960s' space exploration.He says, "The fact that the early cosmonauts had their heartbeat permanently monitored made me curious and excited about new technology and human health."He hoped a career in medicine would allow him to combine science, interaction with people, and medical problem solving.Dr Gronda was soon researching stress radionuclide venticulography in relation to left ventricular performance under effort in patients with severe aortic regurgitation to assess early eligibility for cardiac surgery during a cardiology fellowship at Niguarda General Hospital, Milan, a pioneering centre for cardiovascular disorders and transplantation.He then worked in the intensive coronary care unit.Struggling with patients with acute myocardial infarction before the reperfusion therapy era allowed him to apply the principles of unloading therapy extensively. 1 Although this was an improvement to the status quo, the outlook remained "hopeless," and many sceptics doubted the possibility of developing an effective treatment for heart failure.Dr Gronda was optimistic however, and his optimism was boosted by results from research at the Karolinska Institute, Stockholm, Sweden, and universities in Stanford, CA, and Pittsburgh, PA.The studies revealed, respectively, the benefits of β-blocker drugs in patients with dilated cardiomyopathy and the comparative superiority of heart transplantation in prolonging survival in end-stage cardiomyopathy.
THERESE NEUMANN OF KONNERSREUTH
Journal: JAMA (1962)

The death of the religious stigmatic, Therese Neumann, in Bavarian Germany on Sept. 18 was quietly recorded in both the daily press and the Catholic press. The drab, factual obituaries recalled little of the spirited debates which have arisen periodically over the past 36 years whenever the case of Therese Neumann has been mentioned. During her lifetime, she had been labeled a fraud, an hysteric, or a mystic, depending largely on the personal feeling of the commentator. In this country, her case became widely discussed after World War II, as the result of the many American servicemen who visited her. Therese Neumann was born in Konnersreuth, Germany, in 1898, the oldest of her parent's ten children. Few incidents in her early life distinguished her from other Bavarian peasant girls. At age three she was boarded with an aunt, at six started school, and at 14 went to work for an
Glucose metabolism in patients with psoriasis
Authors: N.U. Friis, N. Hoffmann, M. Gyldenløve, L. Skov, T. Vilsbøll, F.K. Knop, H. Storgaard
Journal: British Journal of Dermatology (2019)

Large epidemiological (population‐based) studies conclude that psoriasis increases the risk of type 2 diabetes (T2D). Our primary objective was to find out whether data from clinical studies support the notion of shared disease mechanisms in psoriasis and T2D. For this purpose, we reviewed clinical studies investigating glucose metabolism in patients with psoriasis. We also present existing theories of how psoriasis might lead to type 2 diabetes. Twenty‐six clinical studies reporting on insulin resistance, glucose tolerance or insulin secretion were eligible for review. Less than half of the studies showed results that suggest a defective glucose metabolism in patients with psoriasis. Overall, the studies lacked information on how known risk‐factors for type 2 diabetes had been taken into account in the study. Furthermore, research methods varied and in all but one study, they might not have been appropriate to detect early and subtle defects in glucose metabolism. The results of clinical studies investigating glucose metabolism in patients with psoriasis are conflicting and presently it seems presumptuous to firmly conclude that patients with psoriasis share disease mechanisms with people with type 2 diabetes. However, seen in conjunction with the epidemiological literature and the proposed theories of shared disease mechanisms, there is ample basis for further research in this area. New studies using sound methods and elaborate research techniques are needed to learn more about glucose metabolism in patients with psoriasis.
Exercise Therapy in Hypertensive Men
Authors: John L. Boyer
Journal: JAMA (1970)

Twenty-three essential hypertensive and 22 normotensive middle-aged men participated in a controlled exercise program for six months; the effect the program had on blood pressures (taken while the men were resting) was determined. There was no other change in therapeutic management during the exercise training period. The exercise medium used was the interval training of the walkjog type, with training intensity based on the actual heart rate expressed as percent of working capacity. A drop in mean diastolic pressure of 11.8 mm Hg and in mean systolic pressure of 13.5 mm Hg occurred in the hypertensive group. There was a mean decrease of 6 mm Hg in the diastolic pressure of the normotensive group, but no significant change in the mean systolic pressure.
Middle Fork
Authors: Elissa Spinner
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AUTHORITY OF PHYSICIANS FOR RAILROADS.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Biological Diversity, Ecology, and Global Climate Change
Authors: Peter R. Jutro
Journal: Environmental Health Perspectives (1991)

Worldwide climate change and loss of biodiversity are issues of global scope and importance that have recently become subjects of considerable public concern. Unlike classical public health issues and many environmental issues, their perceived threat lies in their potential to disrupt ecological functioning and stability rather than from any direct threat that may pose to human health. Over the last 5 years, the international scientific community and the general public have become aware of the implications that atmospheric warming might have for world climate patterns and the resulting changes in the persistence, location, and composition of ecosystems worldwide. At the same time, awareness of the magnitude of current and impending losses of the world's biological diversity has increased. Human activities are currently responsible for a species loss rate that is the most extreme in millions of years, and an alarmingly increasing rate of transformation and fragmentation of natural landscapes. We are just beginning to grasp the meaning of this loss in terms of opportunity costs to human society and the less quantifiable losses associated with simplification of natural ecosystems. In the case of both global warming and reduction of biological diversity, man is affecting nature in an unprecedented fashion, on a global scale, and with unpredictable and frequently irreversible results.
SmgGDS splice variants: Potential novel targets for breast cancer therapeutics.
Authors: C. Bergom, A. Hauser, E. L. Lorimer, R. Li, A. C. Mackinnon, C. L. Williams
Journal: Journal of Clinical Oncology (2011)

10567 Background: Breast cancer malignancy is promoted by the small GTPases K-Ras, Rap1, RhoA, and Rac1. We recently reported that the activity of these GTPases is regulated by two splice variants of SmgGDS, named SmgGDS-558 and SmgGDS-607. SmgGDS is overexpressed in lung and prostate cancer, but its role in breast cancer is unknown. Here we examine whether SmgGDS splice variants are expressed in breast cancer and promote breast cancer malignancy. Methods: Immunohistochemical staining for SmgGDS was performed on archival human breast tumors (N=183) and normal breast tissue (N=22). Immunoblotting was used to detect SmgGDS splice variants in human breast cancer cell lines. siRNAs that silence different SmgGDS splice variants were used to examine the effects of SmgGDS knockdown on breast cancer cell spreading, cell proliferation via [3H]thymidine uptake, anchorage-independent cell growth using soft agar colony assays, and NF-kB activation using luciferase reporter assays. Results: SmgGDS expression was detected in >65% of DCIS and invasive lobular and ductal carcinoma, and in 100% of metastatic tumors, but was detected in only 18% of normal breast tissue specimens (p<0.01). All tested cell lines expressed both SmgGDS splice variants. Silencing SmgGDS-558 or SmgGDS-607 with siRNA significantly diminished cell proliferation (100±2.0 vs. 11.3±1.0 vs. 50.5±2.2, p<0.05) in MCF-7 cells, with similar results in MDA-MB-231 and T47D cells. MCF-7 soft agar colony formation was significantly decreased 71% and 49% when SmgGDS-558 or SmgGDS-607 was silenced. MCF-7 cell spreading was promoted by silencing SmgGDS-558, but not SmgGDS-607. NF-kB activation was also decreased by 30% in resting and TNF-α-treated MCF-7 and MDA-MB-231 cells by silencing either splice variant. Conclusions: SmgGDS is disproportionally expressed in human breast cancers. Reduction of SmgGDS-558 and SmgGDS-607 levels dramatically reduced breast cancer cell proliferation, soft agar colony formation, and NF-kB activation. Our results indicate that SmgGDS splice variants regulate breast cancer malignancy, most likely through their regulation of small GTPases. This study identifies SmgGDS splice variants as novel therapeutic targets in breast cancer.
Race and Crime
Journal: BMJ (1944)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following Race and Crime Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
MENOXENIA.
Authors: None Sphex
Journal: JAMA (1884)

<h3>Editor Journal:</h3> The case of menoxenial anarrhœa recently mentioned in theJournalcalls to mind a somewhat similar instance in Pennsylvania, now of some eight years' standing, where the horæal profluvium was effected by exspuition instead of by the usual mode. If the source of the catamenial issue was bronchial, it seemed to be very low, and at, or near the pulmonary confluence; evidently the flow was not from the epigastrium. Permanent acyesis ensued, but general health of subject remained good. Respecting appliances described for better treatment of hepatic ecpyesis, it would seem that by the invagination of the drainage-tube within an auliscus already internally smeared with pus, some of the latter must adhere to the external surface of the drainage-tube, and be subject of (possible) injury by absorption. The comments of theJournalrelative to proposed congressional aid for the permanent abatement of yellow fever are clearly well taken
Couvelaire Uterus
Authors: Pradip Dashraath, Yee-Chee Wong
Journal: New England Journal of Medicine (2020)

A 29-year-old primigravid woman presented at 33 weeks of gestation with contractions and abdominal tenderness. An emergency cesarean section was performed, and the uterus appeared bruised, a condition known as a Couvelaire uterus.
Sporotrichal arthritis.
Authors: G Chowdhary, A Weinstein, R Klein, B R Mascarenhas
Journal: Annals of the Rheumatic Diseases (1991)

Sporotrichal arthritis is a rare disease entity. Diagnosis is often difficult and delayed. Presentation may be either monoarticular or polyarticular. A case of polyarticular sporotrichal arthritis which exemplifies these problems is reported.
Preclinical and correlative studies of cabozantinib (XL184) in urothelial cancer (UC).
Authors: Andrea Borghese Apolo, Young H. Lee, Fabiola Cecchi, Piyush K. Agarwal, Howard L. Parnes, Kattie Khadar, Amelia Summerell, James L. Gulley, Kathryn Compton, William Douglas Figg, William L. Dahut, Donald P. Bottaro
Journal: Journal of Clinical Oncology (2013)

314 Background: Mounting evidence supports Met as a target in urothelial cancer (UC). Activated Met can promote angiogenesis and tumor growth by upregulating VEGF and may play a role in UC pathogenesis. Cabozantinib inhibits both VEGFR2 and Met pathways. In this study, we assessed shed Met (sMet) levels in the urine and serum of UC patients (pts) and cabozantinib’s effects on HGF-driven UC cell growth and invasion. Methods: sMet levels in serum and urine samples from 31 pts with UC (23 metastatic, 8 muscle-invasive) were correlated with stage, presence of visceral metastases and urinary source. The effects of cabozantinib on 4 human UC-derived cell lines were studied in vitro. Intact RT4, TCC-SUP, T24M2 and T24M3 cells at 80% confluence were serum deprived 16 h, then left untreated or treated with hepatocyte growth factor (HGF) and/or cabozantinib prior to analysis of Met, phospho- (p)Met, pAkt, Akt, pMAPK and MAPK by immunoassay or immunoblotting. Cabozantinib effects on basal and HGF-induced UC cell invasion, proliferation and soft agar growth were measured. Results: Median serum Met levels were modestly higher in pts with metastatic versus muscle-invasive disease. Urinary Met levels were clearly higher in pts with visceral metastasis (p=0.0111) and in urine from ileal conduits and neobladders compared to normally voided urine, regardless of stage (p=0.0489). Met content in UC cell lines was low in RT4 and higher in T24M2, T24M3 and TCC-SUP. Basal pMet content was universally low, increased significantly by HGF and this was reversed by cabozantinib. HGF-driven increases in pAkt/Akt and pMAPK/MAPK in all 4 cell lines were reversed by cabozantinib, as were HGF-enhanced UC cell invasion, proliferation and anchorage independent growth. Conclusions: Median urinary sMet is significantly higher in pts with visceral metastasis and in specimens from ileal conduits and neobladders relative to normally voided urine. UC cell Met content in culture increased with disease grade; HGF stimulated activation of Met and known effectors, and enhanced invasion, growth rate and anchorage-independent growth; cabozantinib effectively reversed these HGF-driven effects. These data support evaluation of cabozantinib in pts with metastatic UC.
Oral iron can improve motor and language development in preschool children
Journal: BMJ (2001)

Oral iron can improve motor and language development in preschool children Oral iron supplementation improves motor and language development in iron deficient preschool children.Iron deficiency anaemia is associated with defects in child development.Stoltzfus et al (p 1389) looked at the effects of iron supplementation, anthelmintic treatment, or both in preschool children in Zanzibar, where anaemia and geohelminth infections were prevalent.Iron supplementation in children with serious iron deficiency conferred important benefits to their motor and language development, even in communities where malaria is endemic and is a major cause of anaemia.