tbuckley/cabot-search huggingface dataset:
Dermatomyositis with the features of inclusion body myositis associated with carcinoma of the bladder: a true association?
Authors: J.M. Grau, M. Perea
Journal: British Journal of Dermatology (2000)

Sir, After carefully reading the article from Talanin et al.1 a major question comes to us. The case presented seems to be simply an association of classical adult dermatomyositis (DM) with carcinoma (of the bladder in this case). Neither the clinical picture nor histopathology of muscle suggests the presence of an associated inclusion body myositis (IBM). IBM represents a well‐differentiated entity among inflammatory myopathies, with proposed diagnostic criteria.2 Talanin et al. suggest the diagnosis of possible IBM on the basis of ‘rimmed vacuoles’ in frozen muscle tissue. Actually, Fig. 4(b) from their paper shows numerous non‐rimmed central or subsarcolemmal vacuoles that are, in our opinion, strongly suggestive of an artefact as a consequence of improper handling of the muscle tissue. All laboratories with experience in frozen muscle tissue3,4 are unpleasantly familiar with this and other artefacts, to the extent that some classical textbooks of muscle pathology include a chapter on artefacts.5–7 In the present case, and in view of the provocative suggestion of an association between paraneoplastic DM and IBM, effort should be taken to demonstrate unequivocally the typical features of IBM such as beta‐amyloid deposition or filamentous inclusions in semithin or ultrathin sections.
The Birthday Party
Authors: Steven A Bondi
Journal: JAMA Pediatrics (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Improving care for patients with stage III/IV NSCLC: Learnings for multidisciplinary teams from the ACCC national quality survey.
Authors: Ravi Salgia, Leigh Boehmer, Catherine Celestin, Judy Yu, David R. Spigel
Journal: Journal of Clinical Oncology (2020)

e19195 Background: Refinement of the multidisciplinary team (MDT) approach continues to offer significant potential for improving the quality of non-small cell lung cancer (NSCLC) care and adherence to guideline-recommended protocols. This opportunity arises, in part, from insufficient characterization of MDT practice patterns and barriers to optimal care provision within U.S. cancer programs. The Association of Community Cancer Centers (ACCC), therefore, conducted a national survey to improve understanding on how patients with stage III/IV NSCLC were diagnosed and managed across different practice settings, with the aim of informing the design and execution of process-improvement plans to address identified barriers. Methods: ACCC convened an expert steering committee of multidisciplinary specialists, including oncologists, thoracic surgeons, pathologists, pulmonologists, and representation from patient advocacy, for a comprehensive, double-blind, web-based survey (January–April 2019), to obtain insights on cancer patient care in a diverse set of U.S. community cancer programs. Results: Of 1211 questionnaires, 639 responses affiliated to 160 unique cancer programs across 44 U.S. states were suitable for analysis. In total, 41% (n = 261) of respondents indicated that their cancer program did not have a thoracic multidisciplinary clinic. The average time to first therapeutic intervention in newly diagnosed patients was 4 weeks (range = 1–10 weeks; n = 298). A significant negative correlation between frequency of tumor board meetings and time to complete disease staging (r = −0.13, P = 0.03) was observed. Nurse navigators ( P = 0.03) and radiation oncologists (P = 0.04) were significantly more likely to engage in shared decision-making practices than other disciplines. The most challenging barriers to delivering high-quality NSCLC care are listed (Table). Conclusions: Multiple opportunities exist to improve the delivery and quality of care for patients with stage III/IV NSCLC, including lowering barriers to effective screening, diagnosis, and care coordination and adhering to evolving standards of care. [Table: see text]
Incomplete Author Name Indexed
Authors: Josiane Bourque, Mohammad Afzali, Patricia Conrod
Journal: JAMA Psychiatry (2018)

David C. Henderson, MD; Enrico Cagliero, MD; Paul M. Copeland, MD; Christina P. Borba, BS, MPH; Anne Eden Evins, MD; Doug Hayden, MA; Mary T. Weber, PhD, APRN, BC, PMHNP; Ellen J. Anderson, MS, RD, LDN; David B. Allison, PhD; Tara B. Daley, BS, MPH; David Schoenfeld, PhD; Donald C. Goff, MD
Risk Assessment of Thyroid Follicular Cell Tumors
Authors: Richard N. Hill, Thomas M. Crisp, Pamela M. Hurley, Sheila L. Rosenthal, Dharm V. Singh
Journal: Environmental Health Perspectives (1998)

Thyroid follicular cell tumors arise in rodents from mutations, perturbations of thyroid and pituitary hormone status with increased stimulation of thyroid cell growth by thyroid-stimulating hormone (TSH), or a combination of the two. The only known human thyroid carcinogen is ionizing radiation. It is not known for certain whether chemicals that affect thyroid cell growth lead to human thyroid cancer. The U.S. Environmental Protection Agency applies the following science policy positions: 1) chemically induced rodent thyroid tumors are presumed to be relevant to humans; 2) when interspecies information is lacking, the default is to assume comparable carcinogenic sensitivity in rodents and humans; 3) adverse rodent noncancer thyroid effects due to chemically induced thyroid-pituitary disruption are presumed to be relevant to humans; 4) linear dose-response considerations are applied to thyroid cancer induced by chemical substances that either do not disrupt thyroid functioning or lack mode of action information; 5) nonlinear thyroid cancer dose-response considerations are applied to chemicals that reduce thyroid hormone levels, increase TSH and thyroid cell division, and are judged to lack mutagenic activity; and 6) nonlinear considerations may be applied in thyroid cancer dose-response assessments on a case-by-case basis for chemicals that disrupt thyroid-pituitary functioning and demonstrate some mutagenic activity. Required data for risk assessment purposes is mode of action information on mutagenicity, increases in follicular cell growth (cell size and number) and thyroid gland weight, thyroid-pituitary hormones, site of action, correlations between doses producing thyroid effects and cancer, and reversibility of effects when dosing ceases.
Left ventricular inflow propogation determined by real-time 3D color doppler echocardiography Fabrice Bauer, Takahiro Shiota, Marta Sitges, Jian Xin Qin, Yong Jin Kim, Hiroyuki Tsujino, James D. Thomas. The Cleveland Clinic Foundation, Cleveland, OH
Journal: Journal of the American College of Cardiology (2001)
A 21-Year-Old Woman With Menstrual Irregularity
Authors: Ann Davis
Journal: JAMA (1997)

<h3>Dr Daley:</h3> Ms K is a 21-year-old single college student who has had difficulty with her menses for a year. She moved to this country in late 1995 to attend college. She studies education and lives with a friend in Boston. She has commercial indemnity insurance. Ms K experienced menarche at the age of 12 years and had regular periods every month lasting about 4 days. Mild cramps accompanied her menses, and she had bloating and breast tenderness prior to them. She has never been on birth control pills and has never been pregnant. Before coming to Boston, she was sexually active, used condoms, and received 2 shots (she does not remember the medication) for birth control at 3-month intervals, with the most recent injection in April or May 1995. She menstruated normally in July through October, but then began bleeding continuously in November 1995. Bleeding varied from heavy to
Antiretroviral Treatment of Adult HIV Infection
Authors: Huldrych F. Günthard, Judith A. Aberg, Joseph J. Eron, Jennifer F. Hoy, Amalio Telenti, Constance A. Benson, David M. Burger, Pedro Cahn, Joel E. Gallant, Marshall J. Glesby, Peter Reiss, Michael S. Saag, David L. Thomas, Donna M. Jacobsen, Paul A. Volberding
Journal: JAMA (2014)

New data and antiretroviral regimens expand treatment choices in resource-rich settings and warrant an update of recommendations to treat adults infected with human immunodeficiency virus (HIV).To provide updated treatment recommendations for adults with HIV, emphasizing when to start treatment; what treatment to start; the use of laboratory monitoring tools; and managing treatment failure, switches, and simplification.An International Antiviral Society-USA panel of experts in HIV research and patient care considered previous data and reviewed new data since the 2012 update with literature searches in PubMed and EMBASE through June 2014. Recommendations and ratings were based on the quality of evidence and consensus.Antiretroviral therapy is recommended for all adults with HIV infection. Evidence for benefits of treatment and quality of available data increase at lower CD4 cell counts. Recommended initial regimens include 2 nucleoside reverse transcriptase inhibitors (NRTIs; abacavir/lamivudine or tenofovir disoproxil fumarate/emtricitabine) and a third single or boosted drug, which should be an integrase strand transfer inhibitor (dolutegravir, elvitegravir, or raltegravir), a nonnucleoside reverse transcriptase inhibitor (efavirenz or rilpivirine) or a boosted protease inhibitor (darunavir or atazanavir). Alternative regimens are available. Boosted protease inhibitor monotherapy is generally not recommended, but NRTI-sparing approaches may be considered. New guidance for optimal timing of monitoring of laboratory parameters is provided. Suspected treatment failure warrants rapid confirmation, performance of resistance testing while the patient is receiving the failing regimen, and evaluation of reasons for failure before consideration of switching therapy. Regimen switches for adverse effects, convenience, or to reduce costs should not jeopardize antiretroviral potency.After confirmed diagnosis of HIV infection, antiretroviral therapy should be initiated in all individuals who are willing and ready to start treatment. Regimens should be selected or changed based on resistance test results with consideration of dosing frequency, pill burden, adverse toxic effect profiles, comorbidities, and drug interactions.
THE MANAGEMENT OF EMPYEMA.
Journal: JAMA (1887)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hepatic Necrosis Associated with Fluothane Anesthesia-J. Lindenbaum and E. Leifer
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Unlearning
Authors: Chris Johnson
Journal: BMJ (2005)

<h3>AIMS</h3> Corneal perfusion chambers are important tools in the development and assessment of ophthalmic drugs. The aim of this study was to design and test a modified perfusion chamber suitable for topical application of drugs to isolated corneoscleral preparations, and which allowed continuous monitoring of endothelial cell function. <h3>METHODS</h3> A polycarbonate and stainless steel perfusion chamber was designed to clamp corneas in a horizontal plane suitable for topical drug delivery. Endothelial cell function was assessed by ultrasonic pachymetry and specular microscopy during perfusion. Epithelial barrier function was assessed by penetration of fluorescein. Leakage was examined by measuring penetration of a large protein, IgG. Tissue architecture after perfusion was examined by conventional histology. <h3>RESULTS</h3> Corneas maintained a functionally and morphologically intact endothelial monolayer during perfusion periods of up to 14 hours. The epithelial barrier function was well preserved. The tissue clamp sealed the preparation effectively against leakage of macromolecules. <h3>CONCLUSION</h3> The new chamber device forms a reliable tool for in vitro drug penetration and toxicity studies in isolated perfused corneoscleral tissue.
Exercise Tests
Authors: C. P. Riley
Journal: JAMA (1972)

<h3>To the Editor.—</h3> Cohn et al (220:501, 1972), in examining the diagnostic accuracy of the two-step test have really combined two different types of e'xercise tests: (1) the standard double Master's two-step test, and (2) submaximal exercise testing graded by heart rate. They employ the principle of heart rate response in the form of a criterion to identify and eliminate 20% of the test procedures which were unsatisfactory due to low heart rate response to the exercise specified by the two-step trip tables. If the trip tables systematically lead to uninterpretable results in one patient out of five, and retrospective employment of the principle of heart rate response correctly identifies this uninterpretable group, one might take this as evidence favoring prospective use of heart rate response in governing the amount of exercise employed, rather than trip tables. Their data suggest that the sensitivity of the test increases (from 66% to
Evaluation of neuroleptic drug use by nursing home elderly under proposed Medicare and Medicaid regulations
Authors: J. Garrard
Journal: JAMA (1991)

Federal regulations for use of neuroleptic drugs in Medicare- and Medicaidcertified nursing homes throughout the United States were implemented October 1,1990. These regulations constitute the first time that prescription drugs are required, by law, to be justified by indications documented in the medical chart. This study used extant data to estimate ineligible neuroleptic use at the individual and nursing home levels had these regulations been in effect in 1976 through 1985. Subjects, randomly sampled admissions (N = 5752) and residents (N = 3191), were followed up for up to 24 months in 60 nursing homes. One half of neuroleptic use in each cohort could be considered ineligible under the regulations; all but one of the nursing homes had one or more individuals who were treated with the ineligible use of neuroleptics. Improvements in documentation and/or prescription of neuroleptic drugs for nursing home elderly will be needed to ensure compliance with these new regulations. (<i>JAMA</i>. 1991;265:463-467)
TREADMILLS
Authors: Eugene P. Simon
Journal: JAMA (1953)

<h3>To the Editor:—</h3> In reply to the letter by Dr. William S. Collens, we are very glad to extend to Dr. Collens, and to all others who have contributed to the use of the treadmill principle in the measurement of physiological response, due credit for any advances that may have led to the development of the equipment described in our article inThe Journal, Sept. 12, 1953. Dr. Collens did permit Dr. Simon to see his equipment. In order to conserve space, however, we did not review the history of the treadmill as it is presently applied. Actually, the equipment described in our paper differed in some details from that of Dr. Collens. It was largely an outgrowth of the type of treadmill used for many years in the laboratory of Dr. Eugene DuBois of the Cornell University Medical College. Our purpose in describing the equipment in some detail was
CONGENITAL VACCIN IMMUNITY.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction
Journal: BMJ (1965)

Deafness-Whetnall BRI&RUTISH 365 some hearing were present.The mother must be reassured that first tests will indicate less hearing than is really present and that the hearing will appear to improve with training.She must realize that once speech is learnt it is heard more easily and the deafness is thus less of a handicap.Some mothers can make easy conversation but others must be shown how to seize and take every opportunity to use speech themselves in order to encourage the child's use of speech.Mothers should attend with their children once a week or once a fortnight at a hearing and speech centre or clinic for deaf children so that they can be taught by a clinical teacher of the deaf, or by a speech therapist, how to carry on helping their children.A hostel for mothers who live too far away for such visits is available at the Royal National Throat, Nose, and Ear Hospital.
Continuing Education Opportunities for Physicians
Journal: JAMA (1984)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
General Practice
Authors: Mac F. Cahal
Journal: JAMA (1963)

<h3>To the Editor:</h3> —Twice in a news item in the Jan 5 issue ofThe Journal(<b>183</b>:23-24) Dr. Robert M. Bucher is quoted as stating that a recent study in two Philadelphia medical schools revealed that only 3% of the students studied had changed their career choices between their freshman year and graduation. This is surprising. In 1960 a questionnaire was mailed to 6,086 graduates of US medical schools by the American Academy of General Practice. There were 1,911 questionnaires completed and returned for evaluation. Study of these revealed that upon beginning their medical studies 28% of the students planned to become specialists. Upon graduation 60% stated they planned to enter specialty practice. This is a difference of 32%, a marked contrast to Dr. Bucher's 3%. The same study showed that upon entering medical school 41% of the subjects planned to become general practitioners, but by the end of