tbuckley/cabot-search huggingface dataset:
SECRETARIES OP THE AMERICAN MEDICAL ASSOCIATION.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Law and Medicine
Authors: Lawrence O. Gostin
Journal: JAMA (1995)

The conventional view that physician-assisted death represents a legal and moral wrong is being reexamined in state referenda and the judiciary. Ballot Measure 16 in Oregon passed, making the state the first to specifically authorize physicians to prescribe drugs to end the life of a terminally ill patient who makes a voluntary, informed choice. The initiative allows an adult with 6 months to live to request a prescription for a lethal dose of drugs; two physicians must certify that the patient is terminally ill, and the patient must request the prescription three times, the last time in writing. The physician must wait 15 days before writing the prescription.<sup>1</sup>On December 7, 1994, a federal district court judge issued a temporary restraining order blocking implementation of the law. The order was based on constitutional grounds that the law provides inadequate safeguards for persons with depression and draws an impermissible distinction
The Life of Nathan Smith Davis, A.M., M.D., LL.D., 1817-1904.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Glaucoma in Monkeys (Cercopithecus Aethiops)
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Error in Figure
Authors: Karen Milcent, Vincent Gajdos
Journal: JAMA Pediatrics (2016)

Karen Milcent, MD, MSc; Sabine Faesch, MD; Christèle Gras-Le Guen, MD, PhD; François Dubos, MD, PhD; Claire Poulalhon, MD; Isabelle Badier, MD; Elisabeth Marc, MD; Christine Laguille, MD; Loïc de Pontual, MD, PhD; Alexis Mosca, MD; Gisèle Nissack, MD; Sandra Biscardi, MD; Hélène Le Hors, MD, PhD; Ferielle Louillet, MD; Andreea Madalina Dumitrescu, MD; Philippe Babe, MD; Christelle Vauloup-Fellous, PharmD, PhD; Jean Bouyer, PhD; Vincent Gajdos, MD, PhD
Euthyroid Hyperthyroxinemia
Authors: GEORGE C. BORST
Journal: Annals of Internal Medicine (1983)

An increasing number of disorders that may cause hyperthyroxinemia without thyrotoxicosis have been recognized in recent years. These include acquired and inherited abnormalities of serum thyroid-hormone-binding proteins, peripheral resistance to thyroid hormones, acute nonthyroidal illness, acute psychiatric illness, and some drug-induced conditions associated with nonthyrotoxic elevations of serum thyroxine. In addition to the laboratory finding of elevated serum thyroxine levels, many of these syndromes are also accompanied by abnormalities in triiodothyronine and free thyroid hormone levels, as well as unresponsiveness of thyroid-stimulating hormone to thyrotropin-releasing hormone, all of which further erroneously indicate a diagnosis of thyrotoxicosis. An awareness of these syndromes and alterations in the results of thyroid function tests that accompany them is important to prevent a misdiagnosis of hyperthyroidism and inappropriate therapy.
The endotoxin antagonist B-464 and antibiotics block the swift increase in alcohol metabolism Laboratory of Hepatobiology and Toxiciology, Dept. of Pharmacology, U. of N. Carolina, Chapel Hill, N.E. and *Eisai Research Institute, Andover, MA
Journal: Hepatology (1995)

With the goal of obtaining a suitable animal model for voluntary oral consumption of ethanol, the investigators selectively bred lines of alcohol-preferring and alcohol-nonpreferring rats, with preference considered as a function of the concentration of ethanol ingested. Studies with these animals showed that drinking is voluntary and not contingent on caloric restriction; that they will work to obtain ethanol even when food and water are freely available, and in so doing, show psychological or behavioral tolerance; that the amount of ethanol voluntarily consumed approaches their apparent maximum capacity for ethanol elimination. This amount of ethanol was capable of altering brain neurotransmitter content, thus exerting a CNS pharmocologic effect. In addition, the rats will bar-press for intravenous administration of ethanol, and with prolonged, free-choice consumption, ethanol intake increases to as much as 12 g per kg body weight per day without producing behavioral deficits, suggesting the development of tolerance.
A multicenter prospective study of image-guided radiofrequency ablation for small breast carcinomas.
Authors: Takayuki Kinoshita, Naohito Yamamoto, Tomomi Fujisawa, Masato Takahashi, Hiroyoshi Doihara, Kenjiro Aogi, Noriaki Wada
Journal: Journal of Clinical Oncology (2014)

1099 Background: As the management of breast carcinoma evolves toward less invasive treatments, the next step is the possibility of removing the primary tumor without surgery. The most promising noninvasive ablation technique is radiofrequency ablation (RFA), which can effectively kill tumor cells with a low complication rate. Methods: To determine if RFA is oncologically and cosmetically appropriate for the local treatment of primary breast carcinoma, this multicenter prospective study used RFA as the sole local treatment of breast tumors ≤ 1.5cm in size on ultrasound and MRI. After confirmation that the standard baseline core biopsy for diagnosis and measurement of tumors markers (ER, PgR, HER-2/neu expression and the presence of the Ki-67 proliferative marker) have been obtained, consent will be obtained and the patient scheduled RFA. All patients received adjuvant radiation therapy. The first primary endpoints of this study is successful tumor ablation, as evidenced by negative findings on vacuum-assisted or core biopsies and imaging studies after RFA. The second primary endpoints is the incidence of procedure related adverse events. The response to ablation was evaluated with both vacuum-assisted or core biopsies and imaging studies every 3 months during the first year. The long-term outcomes were assessed using quality of life measurement scales and imaging studies every 6 months thereafter through year 5. Results: Of the 58 patients who participated in this study, 55 completed the protocol. In 50 of the 55 (91%) treated patients, successful tumor ablation, as determined by negative findings on vacuum-assisted or core biopsies and imaging studies, was confirmed. In these 50 patients, there were no local or distant recurrences after 1 year. The remaining 5 patients with biopsies positive for residual tumor underwent surgical resection. In 46 of the 50 patients with successful ablation, cosmetic outcomes were excellent after 1 year and only 2 patients experienced minor skin burns during the tumor ablation. Conclusions: RFA in patients with early breast carcinoma can achieve local control rates similar to those with wide local excision, but with improved cosmetic results. Clinical trial information: 000008675.
"Orphans" and "foster parents" in research priorities
Authors: S. Vaisrub
Journal: JAMA (1979)

In a recent editorial, Wynder<sup>1</sup>deplores the tendency among public health researchers to focus on questions relating to uncommon rather than common diseases. A conference on the issue of vinyl chloride carcinogenesis, for instance, is likely to get more participation than one on tobacco carcinogenesis. Rather than concentrate on the rare and exotic, Wynder suggests that investigators ask questions that are answerable and immediately relevant to preventive or therapeutic practice. Why is it, we should ask, that cardiovascular disease, most cancers, and most chronic diseases occur with such varying incidence in different populations, and why does the incidence tend to change as individuals move from a low- to a high-risk area?... What better techniques are at hand to dissuade children from beginning to smoke?... How can we induce people to alter their life-styles in the direction of risk factor reduction?<sup>1(p265)</sup> Contrasting views are voiced by Cerami.<sup>2</sup>He
Talc and ovarian cancer
Authors: P. Hartge
Journal: JAMA (1983)

<h3>To the Editor.—</h3> Cramer and co-workers<sup>1</sup>recently reported observing an association between talc use and risk of ovarian cancer. We therefore examined data on talc use that two of us (L.M. and L.P.L.) had collected as part of a case-control interview studyof epithelial ovarian cancer conducted from 1974 to 1977 in the Washington, DC, area.<sup>2</sup>The cases were 197 women with pathologically confirmed primary epithelial ovarian cancers treated in participating hospitals. The controls were 197 women treated at the same hospitals for conditions other than gynecologic, psychiatric, or malignant diseases or pregnancy. The controls were frequency matched to the cases on age, race, and hospital. The interviewers asked questions about reproductive and sexual history, medical history, drug use, and other exposures. Questions about talc use were added to the questionnaire after the study began, so 135 cases and 171 controls were asked about talc exposure. The reported
Five High-Priority Studies
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Christmas depression
Authors: J. R. Hillard
Journal: JAMA (1982)

IS CHRISTMAS hazardous to your mental health? A widespread popular belief says that it is. In fact, a notable proportion of what the general public reads about depressive illness concerns depression at Christmas. The<i>Reader's Guide to Periodical Literature</i>, a standard index of 170 widely circulated popular publications, lists 147 articles on "depression, mental" during the last ten years and 21 deal with the "Christmas depression syndrome." The articles have titles like "Christmas Depression and How to Deal With It," "Beat Those Holiday Blues," and "Holidays Got You Down?" They usually include some "case reports," some comments by a psychiatrist, and some helpful hints on how to avoid depression. Newspapers, radio, and television repeat the same general pattern. But what does the medical literature tell us about this much publicized syndrome? <h3>Professional Literature</h3> The relevant professional literature, almost all of it from the United States, contains articles of two types:
Randomised controlled trial of effects of <i>Helicobacter pylori</i> infection and its eradication on heartburn and gastro-oesophageal reflux: Bristol helicobacter project
Authors: Richard F Harvey, J Athene Lane, Liam J Murray, Ian M Harvey, Jenny L Donovan, Prakash Nair
Journal: BMJ (2004)

<h3>Abstract</h3> <b>Objectives</b> To investigate the effects of <i>Helicobacter pylori</i> infection and its eradication on heartburn and gastro-oesophageal reflux. <b>Design</b> Cross sectional study, followed by a randomised placebo controlled trial. <b>Setting</b> Seven general practices in Bristol, England. <b>Participants</b> 10 537 people, aged 20-59 years, with and without <i>H pylori</i> infection (determined by the <sup>13</sup>C-urea breath test). <b>Main outcome measures</b> Prevalence of heartburn and gastro-oesophageal acid reflux at baseline and two years after treatment to eradicate <i>H pylori</i> infection. <b>Results</b> At baseline, <i>H pylori</i> infection was associated with increased prevalence of heartburn (odds ratio 1.14, 95% confidence interval 1.05 to 1.23) but not reflux (1.05, 0.97 to 1.14). In participants with <i>H pylori</i> infection, active treatment had no effect on the overall prevalence of heartburn (0.99, 0.88 to 1.12) or reflux (1.04, 0.91 to 1.19) and did not improve pre-existing symptoms of heartburn or reflux. <b>Conclusions</b><i>H pylori</i> infection is associated with a slightly increased prevalence of heartburn but not reflux. Treatment to eradicate <i>H pylori</i> has no net benefit in patients with heartburn or gastro-oesophageal reflux.
Use of Molecular Probes to Assess Geographic Distribution of Pfiesteria Species
Authors: Parke A. Rublee, Jason W. Kempton, Eric F. Schaefer, Coy Allen, Janera Harris, David W. Oldach, Holly Bowers, Torstein Tengs, JoAnn M. Burkholder, H. B. Glasgow
Journal: Environmental Health Perspectives (2001)
Questions and Answers
Journal: JAMA (1974)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ERRATUM
Journal: Journal of Clinical Oncology (2004)

A sentence in the final paragraph of the paper on page 1901 contains a dosage error for cyclophosphamide.The sentence mistakenly reads, "At 36 months of age, both vincristine and cyclophosphamide are dosed on the basis of BSA (1.5 mg/m 2 and 2.2 mg/m 2 , respectively)."The correct sentence should read, "At 36 months of age, both vincristine and cyclophosphamide are dosed on the basis of BSA (1.5 mg/m 2 and 2.2 grams per m 2 , respectively)."
Irradiation of glioblastoma cells can promote enhanced motility and invasiveness, both in vitro and in vivo through activation of MRCK
Authors: Joanna Birch, Lesley Gilmour, Karen Strathdee, Antoine Vallatos, Heather Mckinnon, Martin Drysdale, Mike Olson, Anthony Chalmers
Journal: Neuro-Oncology (2018)

Glioblastoma (GBM) is one of the most common and aggressive forms of brain cancer. It is associated with poor survival rates, in part due to the infiltrative nature of GBM tumour cells. This allows GBM cells to disseminate through the brain via existing white matter tracts and perivascular spaces making complete surgical resection unachievable and contributing to high recurrence rates. For the majority of patients treatment of GBM includes radiotherapy. However, radiation resistance results in populations of surviving tumour cells with the potential for modified behaviour through radiation-induced alterations in signalling and gene expression profiles Myotonic dystrophy kinase-related CDC42- binding kinase (MRCK) is involved in regulating actin-myosin dynamics during cell migration through phosphorylation of its targets MLC2 and MYPT. Upon radiation of GBM cell lines in vivo we observed an increase in MRCK activity which was concomitant with a significant increase in GBM cell motility and invasion in in vitro and ex vivo assays. In support of these data we have observed increased MRCK activity at the invasive edges of both clinical GBM samples and an orthotopic GBM xenograft model that recapitulates key histological features of human GBM. Furthermore, therapeutic doses of irradiation were found to promote GBM invasion in vivo in this xenograft model, along with increased pMYPT. These observations suggest that MRCK activity may be required to promote invasion following irradiation and therefore may present a promising novel target for GBM treatment.In support of this, we found we were able to reverse the radiation dependent promotion of GBM cell motility via MRCK RNAi or by using a novel MRCK selective inhibitor, BDP-9066. These data suggest that MRCK activity is indeed required for GBM invasion and may offer a potential new target for GBM management.
Transplantation biology and medicine. Remarks about the Seventh International Congress of the Transplantation Society, Rome, Sept 3-8, 1978
Authors: F. T. Rapaport
Journal: JAMA (1979)

THE RAPID growth of transplantation since its relatively modest beginnings at the biennial conferences of the New York Academy of Sciences almost a quarter of a century ago has extended the duration of the international congresses to a full five days. The number of new ideas and facts presented at these gatherings continues to attest to the vitality of the transplantation community. More than ever this discipline has continued to benefit from the intimate interaction (and not infrequently cross-irritation) of biologists and clinicians for whom the Transplantation Society serves as a unique, common forum. These considerations were never more in evidence than at the recently concluded Seventh International Congress of the Transplantation Society—a broadly interdisciplinary gathering of more than 1,400 contributors representing 38 different nations throughout the world. There is no question that a preponderance of the 455 reviews, special reports, and invited talks presented at this gathering will have
Fatal compulsive water drinking
Authors: M. Rendell
Journal: JAMA (1978)

In two cases of psychogenic polydipsia, water intoxication developed and contributed to the patient's death. The treatment of the patient with psychogenic polydipsia has been based on the presumed reversibility of the condition. Treatment of such patients must be reconsidered in light of these deaths. (<i>JAMA</i>240:2557-2559, 1978)
Analysis of costs and outcomes of renal transplantation at one center. Its implications
Authors: O. Salvatierra
Journal: JAMA (1979)

A cost increase of more than 900% for medical services to dialysis patients and transplant recipients has been projected during the decade 1974 to 1984. To evaluate the role of renal transplantation in the End-Stage Renal Disease Program, we analyzed direct costs and patient outcomes in 466 consecutive transplants at our center. A successful transplant from either a living related or cadaver donor cost less than $7,000 per year for two years of graft function. The cost of transplants rejected during the second year also proved cost-effective when compared with the yearly costs of maintenance-facility hemodialysis. Patient survival was 100% at two years for recipients of a transplant from a living related donor and 84% at two years for recipients of a transplant from a cadaver. Renal transplantation can reduce the rising costs for end-stage renal disease patient care, without reducing life expectancy. (<i>JAMA</i>241:1469-1473, 1979)
Outbreak of Campylobacter Enteritis Associated With Cross-Contamination of Food--Oklahoma, 1996
Journal: JAMA (1998)

On August 29, 1996, the Jackson County Health Department (JCHD) in southwestern Oklahoma notified the Oklahoma State Department of Health (OSDH) of a cluster of Campylobacter jejuni infections that occurred during August 16-20 among persons who had eaten lunch at a local restaurant on August 15. This report summarizes the investigation of these cases and indicates that C. jejuni infection was most likely acquired from eating lettuce cross-contaminated with raw chicken. This report also emphasizes the need to keep certain foods and cooking utensils separate during food handling.