tbuckley/cabot-search huggingface dataset:
British Journal of Haematology, Oxford
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BOOK REVIEW
Authors: G. J. LESSER
Journal: JNCI Journal of the National Cancer Institute (1993)

Journal Article BOOK REVIEW Get access Cancer Pain Richard B. Patt , ed. Philadelphia : J. B. Lippincott , 1993 . 650 pp., illus. $79.50. ISBN 0-397-51138-8 GLENN J. LESSER, M.D. GLENN J. LESSER, M.D. The Johns Hopkins Oncology Center600 N. Wolfe St. Baltimore, MD 21287 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 85, Issue 11, 2 June 1993, Pages 917–918, https://doi.org/10.1093/jnci/85.11.917 Published: 02 June 1993
Highlights
Journal: JAMA Pediatrics (2017)

Given the high prevalence of obesity in the United States, the search for feasible and effective treatments that can be used in the community is critical.Wilfley et al conducted a randomized clinical trial of a family-based intervention for children who were overweight or obese aged 7 to 11 years and their parents.Intensive behavioral intervention programs with enhanced social facilitation maintenance, especially at higher doses, improved weight outcomes.There is a need to translate these types of effective family-based weight management interventions into routine clinical care.
XI. Medicine seeks to be 'scientific'
Authors: L. S. King
Journal: JAMA (1983)

In the previous essay, I suggested 1886 as a convenient vantage point from which we can readily examine the progress of medical science. That date serves as a meeting point of two diverse currents. One of them, which waxed greatly, I identify as "science"—in quotation marks because the meaning of the term is by no means agreed upon, at present. The other current, which waned in the last two decades of the century, has no simple or widely accepted name. I would identify it by the cumbersome title, the "old-fashioned medical practice" and for convenience refer to it as the "art of medicine," a term that is even less clear than "science." Today the meanings of "art" and "science" may be fuzzy, but a century ago they seemed quite obvious. And a century ago the distinction between them had considerable significance, as well as clarity. A textbook of 1883,<i>A</i>
Abstract 1804: Role of microRNAs in colorectal adenoma progression
Authors: LaShanale M. Wallace, Aneese F. Chaudhry, Karen I. Aikhionbare, Xuebiao Yao, Felix O. Aikhionbare
Journal: Cancer Research (2019)

Abstract Colorectal cancer (CRC) survival rates are stage related and majority of patients (75%) with CRC have sporadic of the disease which is in form of adenoma. Most of colorectal adenocarcinomas precursors are adenomatous polyps. Moreover, CRC appears to be an age related disease and studies have shown that mutations in mtDNA appear to accumulate with age because of inadequate repair. Also, oxidative stress has been shown to affect mitochondrial proteins resulting in a decrease of mitochondrial function associated with the precursor lesions of cancer. Recent findings suggest that the mitochondrion has sequences that code for certain miRNA which can regulate different pathways frequently dysregulated in cancer including colorectal cancer (CRC). Isolation of mitochondria RNA from colorectal precancerous polyps, cancer, and normal adjacent tissue samples was performed and assessed for gene expression differences using quantitative reverse transcription PCR. We demonstrate that mitochondria genome expression of miRNAs miR-24, miR 181, miR 210, and miR 21 in colorectal tissue samples varies during disease progression. Expression of microRNAs 24, 181, and 210 progressively increased from the earliest precancerous polyp to cancer. In addition, miR-210 and miR-181 expression increased 3 folds in villous adenomas when compared to tubular adenoma. Meanwhile, miR 21 increased progressively in adenoma tissues but decreased almost 4 folds in cancer tissues when compared to villous adenoma tissue. These results suggest miRNAs within the mitochondria genome may regulate important mitochondrial functional pathways leading to a more favorable environment for transformation or progression of adenomas to cancerous tumors. Citation Format: LaShanale M. Wallace, Aneese F. Chaudhry, Karen I. Aikhionbare, Xuebiao Yao, Felix O. Aikhionbare. Role of microRNAs in colorectal adenoma progression [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1804.
Microbe Hunters.
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TUBERCULOSIS IN PRISONS.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pediatrics Clinical Research
Authors: B. Wrede, O. Peters, U. Kordes, T. Kutluk, M. Hasselblatt, M. Rytting, S. Rutkowski, A. Mahajan, T. Pietsch, P. Thall, J. E. Wolff, J. E. Wolff, P. Thall, S. Pfister, M. Rytting, R. Bingham, T. Vats, C. Rokes, A. Mahajan, R. Brown, K. M. Creach, J. B. Rubin, J. R. Leonard, D. D. Limbrick, M. D. Smyth, R. G. Dacey, K. M. Rich, J. L. Dowling, G. P. Linette, A. A. King, J. M. Michalski, J. R. Simpson, T. S. Park, A. Perry, D. B. Mansur, S. Gururangan, A. P. Panandikar, A. Broniscer, A. Huang, S. Kellie, D. Ellison, A. Gajjar, D. Aguilera, S. Goldman, T. Tomita, J. Fangusaro, S. Gururangan, J. Fangusaro, T. Y. Poussaint, A. Onar, R. Gilbertson, R. Packer, R. McClendon, H. Friedman, J. Boyett, A. Broniscer, J. N. Baker, M. Tagen, A. Onar-Thomas, R. J. Gilbertson, A. M. Davidoff, A. Pai-Panandiker, W. Leung, T. K. Chin, C. F. Stewart, M. Kocak, C. Rowland, T. E. Merchant, S. Kaste, A. Gajjar, J. Allen, B. Donahue, J. Mathew, C. Kretschmar, I. Pollack, R. Jakacki, M. Massimino, V. Biassoni, L. Gandola, P. Ferroli, I. Bongarzone, F. Spreafico, E. Pecori, E. Schiavello, P. Modena, F. Bach, P. Potepan, I. Slavc, A. Peyrl, T. Czech, C. Haberler, K. Dieckmann, R. J. Brown, G. Dhall, A. Marachelian, A. Gozali, A. Butturini, F. Gilles, S. J. Thompson, S. Gardner, J. L. Finlay, R. J. Brown, G. Dhall, S. Goldman, D. D. Eisenstat, F. Gilles, A. Evans, J. L. Finlay
Journal: Neuro-Oncology (2010)
Prognostic significance of prolonged repolarization at discharge in a large population of post-myocardial infarction patients
Authors: F. Hernández-Bernal, R. Latini, A. Villella, S. Barlera, A. Volpi, E. Grossi, R. Turato, A.P. Maggioni, G. Zuanetti
Journal: Journal of the American College of Cardiology (1998)
Silicone horseshoe ties off reflux
Journal: JAMA (1979)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Booknote
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
People's preferences.
Journal: BMJ (1971)

gastric mucosa is an important predisposing factor.But in Jones and his colleagues' cases the emphasis was on duodenal ulceration, and a purely ischaemic aetiology seems unlikely.A common factor may enter into the causation of both lesions.The severity of atheroma is related to cigarette smoking,6 and the evidence points to a relationship between peptic ulceration and smoking.7 Unfortunately there are no data on the smoking habits of Jones and his colleagues' patients.Be this as it may, it is important to know of the association lest haematemesis in a patient with an abdominal aneurysm is automatically attributed to its incipient rupture.
Cardiac Diagnosis
Authors: David H. Spodick
Journal: JAMA (1969)

Aimed at general practitioners and internists,<i>Cardiac Diagnosis</i>is comprehensive without being overwhelming, and can provide the non- specialist with adequate depth of understanding. Uneven balance in the early chapters is partly due to contributions by eight co-authors. Yet, these are individually excellent —notably Chou's synopsis of vector-cardiography, with appropriate caveats about its usefulness; the superb coverage, by Adolph, of cardiac catheterization and angiography; and the chapter on curable forms of hypertension by Gaffney, Hanenson, and Loggie. The most distinctive feature of the book is Noble Fowler's presentation, with his customary simplicity, clarity, and force, of the many aspects of cardiology for which he can refer to his own experience to provide statistical data and practical advice. These include outstanding sections on valvular heart disease and cyanotic congenital heart disease, a good chapter on continuous murmurs, and one on innocent murmurs which epitomizes the author's common sense approach, and a
Book Review A Treatise on the Surgical Technique of Otorhinolaryngology . Georges Portmann. Collaborators: H. Retrouvey, J. Despons, P. Leduc and G. Martinaud. Translation by Pierre Viole, M.D. 4°, cloth, 675 pp., with 474 illustrations and 2 colored plates. Baltimore: William Wood &amp; Co., 1939. $12.50.
Journal: New England Journal of Medicine (1940)
Delayed diagnosis of disease
Authors: H. M. Spiro
Journal: JAMA (1985)

MANY methods to limit the costs of medical care are being scrutinized. Corporations are asking their employees to pay a larger portion of their "health care" bills; diagnosis-related groups have been introduced to limit the number of diagnostic studies and other related costs for each hospital illness. These and other external measures aim at financially restricting, "capping" is the word, what the physician can do. Why do physicians order so many tests; why do their patients so enthusiastically agree to them—when they do not demand them? Is it greed on the physician's part or fear or ignorance on the patient's? I do not think so. The new diagnostic and therapeutic techniques available in ever-increasing varieties to physicians since about 1970 make superb contributions to medical care and make the work of the clinician easier and much more precise. The problem lies not with the answers that the new technology provides,
Error in Text
Authors: Joshua Denson, Leora Horwitz, Scott Sherman
Journal: JAMA (2017)

Drs Arora and Farnan, when a care transition is approaching, clinicians often attempt to discharge as many patients as possible to minimize the effect of the service change on a new team of physicians. 2 Therefore, the transition in care might itself generate a patient cohort that is more complex, more ill, and at greater risk.Also, the transition may have produced longer lengths of stay after transition because of disruptions to clinical care and discharge planning.Disentangling the etiology of the observed adverse outcomes is difficult.However, a large single-center study on the association between end-of-rotation transition and mortality similarly demonstrated a greater adjusted hospital mortality risk for end-of-rotation handoff patients, 3 and the design of that investigation excluded immortal time bias as a potential contributor.Other studies evaluating end-of-rotation transition also suggest these patients are at risk for longer lengths of stay and higher costs. 4,5Causality is difficult to prove and we do not attempt to claim such from the results, but it seems apparent that an association exists.We believe that association was further supported by our conservative decision to adjust for both length of stay and a validated comorbidity score.Although we agree that our alternative analysis removed any immortal time bias, it has a number of important limitations of its own.Less than two-thirds of the intervention cohort in this analysis actually underwent end-of-rotation transition, potentially diluting any observable effect.Moreover, this analysis omitted 38% to 47% of patients who truly underwent end-of-rotation transition, potentially omitting those at highest risk of adverse outcomes.In addition, this analysis had only 15% the sample size of the main analysis and may have been underpowered.Therefore, we cannot be confident that these results are more accurate than the main analysis.Sadhu proposes an alternative analysis whereby the control group is constructed around an arbitrary date 2 weeks apart from the transition date.This is an interesting idea but would likely also be subject to limitations of crossover and sample size.In conclusion, we believe Sadhu's comments are an important consideration when evaluating cohort studies, but we disagree with his conclusions.Further studies should avoid immortal time and use designs that can demonstrate causality or investigate effectiveness of a targeted intervention.
The foreign medical graduate issue and US hospitals. In regard to Public Law 94--484
Authors: B. M. Weinstein
Journal: JAMA (1979)

THE HEALTH Professions Educational Assistance Act of 1976 (Public Law 94-484) was intended to decrease the role of the foreign medical graduate (FMG) in American medicine and to increase the production and availability of American physicians. However, certain hospitals and the communities they serve have developed a dependence on FMGs. That US medical graduates, group practitioners, or middle-level health professionals can replace these FMGs does not appear real, at least in the near future. To avoid any substantial disruption of health services during the transition period, Congress included a waiver for those purposes in Public Law 94-484. This was originally administered as a blanket waiver and now apparently will be extended on a case-by-case basis until 1980 in accordance with Public Law 95-83. Plans beyond 1980 are unclear. According to a recent study by the American Medical Association, 23% of house staff positions surveyed were filled, as of July 1977,
Abstract MP069: A Genetic Association Study of D-dimer Levels with 50K SNPs from a Candidate Gene Chip in Four Ethnic Groups: the Candidate Gene Association Resource (CARe) consortium
Authors: Lu-Chen Weng, Weihong Tang, Stephen S Rich, Nicholas L Smith, Susan Redline, Christopher J O’Donnell, Saonli Basu, Alexander P Reiner, Joseph A Delaney, Russell P Tracy, Cameron Palmer, Taylor Young, Qiong Yang, Aaron R Folsom, Mary Cushman
Journal: Circulation (2012)

Introduction: D-dimer, a marker of blood coagulation and fibrinolysis, is a widely-used biomarker of venous thromboembolism. While the coagulation factors V, III, II and fibrinogen alpha chain genes contain known genetic determinants of D-dimer, other determinants are not well characterized, especially in populations other than European Americans (EAs); no data have been reported for Asian American populations. Hypothesis: Large-scale candidate gene association analysis will identify D-dimer related gene variants in EA, African-American (AA), Chinese, and Hispanic populations. Methods: Four cohorts, comprised of 6,848 EA, 2,192 AAs, 670 Chinese, and 1,286 Hispanics from Cleveland Family Study, Cardiovascular Health Study, Framingham Heart Study, and Multi-Ethnic Study of Atherosclerosis in the Candidate Gene Association Resource (CARe) consortium, were included. The inverse normal transformed residual of D-dimer was used in genetic analysis. About 50,000 SNPs located in 2,100 inflammation and atherosclerosis-related genes were genotyped using the custom ITMAT-Broad-CARe (IBC) chip and analyzed by linear regression adjusted for age, sex, study site, and principal components to account for potential population stratification in each cohort and race group. Significance was set at p&lt;2x10-6 after accounting for multiple testing. Results: Twelve SNPs in the coagulation factor V gene and 3 SNPs in the fibrinogen alpha chain genes exceeded the significant p-value threshold in EA. The top SNPs in these two regions were rs6025 (p-value=7.41x10-16) and rs13109457 (p-value=7.52x10-7), respectively. The signals for the remaining significant SNPs in these two regions were no longer statistically significant after adjusting for the known functional SNPs in each region (rs6025 and rs6050, respectively). The top signal at the coagulation factor V gene was replicated in Hispanics but not other race groups. Neither AA nor the other race groups replicated the signals for fibrinogen alpha chain gene. No additional variants in AA, Chinese, or Hispanics showed significant associations with D-dimer, but several SNPs in neuregulin 1 and Bruton agammaglobulinemia tyrosine kinase for AA and vanin 1 for Chinese were suggestively associated with D-dimer levels (p-value&lt;5x10-5). Conclusion: Our study replicated previously reported associations of D-dimer with coagulation factor V and fibrinogen alpha chain variants in EAs and identified coagulation factor V variation in Hispanics. Additional studies are required to confirm the suggestive findings in AAs, Chinese, and Hispanic populations.
Diagnostic imaging procedures in acute pancreatitis. Comparison of ultrasound, intravenous cholangiography, and oral cholecystography
Authors: M. I. Burrell
Journal: JAMA (1979)

To evaluate the role of intravenous cholangiography (IVC), ultrasound and oral cholecystography in the diagnosis of gallstone pancreatitis, 20 patients with acute pancreatitis were studied during the first three days of an attack. The IVC successfully demonstrated the common bile duct and gallbladder in 17 (85%) of 20 patients. The ultrasound studies showed the gallbladder in all 18 patients in whom the gallbladder was present. The common duct was not seen by ultrasound in any patient and the pancreas was abnormal in all patients. In the three patients with gallbladder stones these were identified on both IVC and ultrasound. Common duct stones in three patients were seen only by IVC (two of these patients had concurrent gallbladder stones and one after cholecystectomy). Oral cholecystography was of limited usefulness, although the 50% visualization rate was higher than the literature suggests. (<i>JAMA</i>242:342-343, 1979)