tbuckley/cabot-search huggingface dataset:
PROTAMINE INSULIN AND DIET IN DIABETES MELLITUS
Authors: H. M. T.
Journal: Annals of Internal Medicine (1938)

Editorial1 May 1938PROTAMINE INSULIN AND DIET IN DIABETES MELLITUSH. M. T. JR.H. M. T. JR.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-11-11-2048 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptBefore enumerating methods for achieving the best regulation of the diabetic regimen it is important to marshall the available facts that throw light on this phase of the disease. Only in this way can we clarify our objective and estimate the degree of success attained.Adequate regulation of a patient with diabetes mellitus has been thought for a long time to consist in balancing the diet and insulin in a way that maintains the urine free from sugar, avoids periods of hyperglycemia, and at the same time avoids insulin reactions. In many patients this degree of regulation has not been...1 MOSENTHAL HO: Hyperglycemia; evaluation in treatment of diabetes mellitus, Jr. Am. Med. Assoc., 1935, cv, 484-488. CrossrefGoogle Scholar2 THOMAS HM: The renal threshold for glucose, ANN. INT. MED. (In press.) Google Scholar3 DE WESSELOWGRIFFITHS OLWJ: Insulin resistance in diabetes mellitus and the effect of dietary carbohydrate, Quart. Jr. Med., N. S., 1938, vii, 17-28. Google Scholar4 BRIDGE EM: The action of insulin on glycogen reserve, Bull. Johns Hopkins Hosp., 1938, lxii, 408-421. Google Scholar5 BRIDGEWINTER EMEA: Diabetes, carbohydrate combustion and insulin action, Bull. Johns Hopkins Hosp. (In press.) Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1938Volume 11, Issue 11Page: 2048-2050KeywordsDiabetes mellitusDietHyperglycemiaInsulinProtaminesUrine ePublished: 1 December 2008 Issue Published: 1 May 1938 PDF downloadLoading ...
Authors' Reply
Authors: Andrew D. Rule, Kitty J. Jager, Jan A.J.G. van den Brand, Pierre Delanaye
Journal: Journal of the American Society of Nephrology (2019)

We agree with Trachtman1 regarding the potential benefits for both young and elderly with age-based eGFR thresholds. We disagree with the points raised by Coresh et al.2 First, despite the cited guidelines, there is not widespread consensus among practicing nephrologists that elderly patients with an eGFR of 45–59 ml/min per 1.73 m2 and no albuminuria have diseased kidneys.3 Further, primary care guidelines fail to see clinical benefit with this classification.4 Second, although absolute risks are often important, humans have a limited lifespan and it is not clear that an hazard ratio of 1.2 for risk translates into clinically meaningful life years lost.5 The statistical prognostic models relating eGFR to outcomes were on the basis of relative risk and the “heat maps” were on the basis of relative risk. The eGFR level associated with lowest risk (absolute or relative) declines with older age and this is not accounted for in the CKD definition. As with any epidemiologic study, a small hazard ratio of 1.2 could easily be due to bias (high-risk rather than just general population cohorts were used in the CKD prognosis consortium analyses) or residual confounding (such as systemic microvascular disease or lower nephron endowment linked to other complications of lower birthweight). Third, a causal pathway linking the age-related decline in eGFR to an increased risk of nonrenal outcomes is lacking. We concur that older patients with a low-normal GFR have less renal reserves putting them at increased risk for kidney failure, but this is too rare of an event to justify a disease label. High BP and glucose can be lowered with medications with a demonstrable clinical benefit, but there is no evidence that eGFR can be increased for a clinical benefit. A fairer comparison would be pulmonary function tests, which are reported with age-appropriate reference ranges due to the age-related decline in pulmonary function.6 We hope that the CKD prognosis consortium and Kidney Disease Improving Global Outcomes will reconsider the age-related decline in eGFR for the purposes of identifying persons with diseased kidneys. DISCLOSURES None.
The Medical Register of New York, New Jersey, and Connecticut. 1892-3.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
IN THIS ISSUE
Journal: JNCI Journal of the National Cancer Institute (1996)

DNA RepairGenes that repair damaged DNA are essential to preserve normal cellular function.Studies suggest that mutations in repair genes accelerate rates of other genetic mutations and eventually lead to tumorigenesis.In a special article, Rhyu (p.240) discusses repair mechanisms of the MutS and MutL bacterial genes, comparing them with the mechanisms of eukaryotic MutS and MutL homologues.Mutations of these homologues cause hereditary nonpolyposis colorectal carcinoma (HNPCC) and are implicated in some sporadic (nonhereditary) colorectal cancers.The author reviews and explores mismatch repair, homologous recombination, gene conversion, and other molecular events requiring MutS and MutL.Although the steps that lead from MutS and MutL mutations to HNPCC remain largely unknown, Rhyu speculates that the resulting increase in DNA damage could enhance the likelihood of mutations in tumor suppressor genes and/or oncogenes, or that certain crucial genes may be particularly prone to unrepaired replication errors.
Psychiatric nursing.
Journal: BMJ (1969)

Another part of this study was a comparison of the effects of combining sulphamethoxazole and trimethoprim in different proportions.The ratio between them used in the series of patients already referred to was 5: 1, the same as in the commercially obtainable preparation.In a separate series 10: 1 and 2: 1 were compared, and no clear indication was obtained that any one of these three is preferable to the others.
Cancer among nuclear test participants
Journal: JAMA (1984)

<h3>In Reply.—</h3> We accept Dr Grossman's criticism that the fate of the 145 participants could markedly affect the outcome of the study but do not accept his implication that, because they could not be traced, they have all died. Some of the untraced 145 participants almost certainly have died and some of these of cancer, but how many? Of the 145, we knew the Social Security Account Number (SSAN) for 63. Evidence of death was not found after these were submitted to the Internal Revenue Service, Veterans Administration, and Social Security Death Registry. Those without an SSAN were checked through the Veterans Administration, National Personnel Records Center, Social Security Administration, and Federal Bureau of Investigation for either an SSAN or evidence of death. No other sources of data were available unless we had each name reviewed by each state for each of 22 years. Even if this had been done,
Circulation Research, New York
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The hyperthyroid rat heart produces diminished HSP 70 m RNA by preconditioning investigation of mechanisms Dennis Cokkinos, Costas Pantos, V. Malliopoulou, S. Tzeis, DD Cokkinos, N. Steimberg, H. Carageorgiou, DV Varonos. Onassis Cardiac Surgery Center, Athens, Greece
Journal: Journal of the American College of Cardiology (2001)
Mountain Fever
Authors: A. Wise
Journal: BMJ (1880)

month", when in reality he had only been one night.The pupils -were slightly unequal, but both active.Examination of his chest showed his heart and lungs to be healthy.He complained of pain in his head.July 20th.He had a convulsive attack to-day, after which it was *found that his left side was paralysed, and the pupils were markedly unequal.He complained of pain in his head.August 24th.He had been rather helpless since the last note was made, and been confined to bed ; yet he remained in the very best of spirits.When asked how he was, he said he felt " Very well", repeating the words " very well".He sang occasionally, and talked a good deal of the fine boats he possessed, and addressed strangers by some familiar name, such as " Joe".He laboured under the delusion of mistaken identity, and held out his hand to shake hands with strangers, believing he had known them all his life.He tookl his food well and enjoyed it.November 20th.Verylittle change had occurred since the last note was taken, unless it was that his voice was not so strong, and was very tre- mulous when he spoke; he took his food well, but it had ceased to do him the same amount of good as at first, as he had lately lost flesh, -showing that nutrition was becoming impaired.January 8th, I88o.He was generally veryhappy and content, although he was cjuite helpless, and had to be lifted out and into bed.A bed-sore was forming over the sacrum.Pulse 86.The urine, being examined, was found to be healthy.February 3rd.He sank and died.
Mallory-Weiss Syndrome: A Commonly Overlooked Cause of Upper Gastrointestinal Bleeding
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction: Four-in-One Antibodies Have Superior Cancer Inhibitory Activity against EGFR, HER2, HER3, and VEGF through Disruption of HER/MET Crosstalk
Authors: Shi Hu, Wenyan Fu, Weihao Xu, Yang Yang, Melissa Cruz, Sandra D. Berezov, Daniel Jorissen, Hiroaki Takeda, Wangdong Zhu
Journal: Cancer Research (2019)
Infectious Diseases Associated With Renal Homotransplantation
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Undergraduate Medical Education
Authors: Anne E. Crowley
Journal: JAMA (1987)

<h3>MEDICAL SCHOOLS Accreditation</h3> The official accrediting body for educational programs leading to the MD degree is the Liaison Committee on Medical Education (LCME), which is listed for this purpose by the US Secretary of Education and recognized by the Council on Postsecondary Accreditation. (For membership of the LCME, see Appendix I.) The criteria by which the LCME accredits such programs in the United States, and in Canada in cooperation with the Committee for the Accreditation of Canadian Medical Schools, are published in<i>Functions and Structure of a Medical School: Standards for Accreditation of Medical Education Programs Leading to the MD Degree</i>. Copies of this document are available from the LCME Office, American Medical Association Division of Undergraduate Medical Education, 535 N Dearborn St, Chicago, IL 60610; or the LCME Office, Association of American Medical Colleges Office of Accreditation, One Dupont Circle NW, Washington, DC 20036. <h3>Accredited Programs in Medical Education</h3>
SUGGESTIONS FOR THE RECONSTRUCTION OF SYPHILITIC NOSES.*
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Memoranda on Army General Hospital Administration.
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
QUANTITATIVE TESTS FOR PROTEOLYSIS.
Authors: A. L. BENEDICT
Journal: JAMA (1901)

It is a remarkable fact that, after ten years' scientific —or, at least, experimental—study of the stomach, none of the methods of chemical examination of gastric contents in common use deals directly with the prime function of this organ. We draw inferences from the rapidity with which the stomach passes its contents into the intestine, often relying on fallacious tests, such as that with salol. We measure as carefully as possible the hydrochloric acid that is present in excess of that functionally active, and assure ourselves that more ferment has been secreted than has been utilized. We note how much or how little the gastric secretion has interfered with the digestion of starches by ptyalin We quantitate and qualitate abnormal accompaniments of digestion. In short, we tax our ingenuity to investigate all the circumstances and accessories of gastric digestion and ignore the direct question as to how well or how
Deposition and Clearance of Inhaled Particles
Authors: Bruce O. Stuart
Journal: Environmental Health Perspectives (1976)

Theoretical models of respiratory tract deposition of inhaled particles are compared to experimental studies of deposition patterns in humans and animals, as determined principally by particle size, density, respiratory rate and flow parameters. Various models of inhaled particle deposition make use of convenient approximations of the respiratory tract to predict tractional deposition according to fundamental physical processes of impaction, sedimentation, and diffusion. These theoretical models for both total deposition and regional (nasopharyngeal, tracheobronchial, and pulmonary) deposition are compared with experimental studies of inhaled dusts in humans or experimental animals that have been performed in many laboratories over several decades. Reasonable correlation has been obtained between theoretical and experimental studies, but the behavior of very fine (less than 0.01 mum) particles requires further refinement.Properties of particle shape, charge, and hygroscopicity as well as the degree of respiratory tract pathology also influence deposition patterns and further experimental work is urgently needed in these areas. The influence upon deposition patterns of dynamic alterations in inspiratory flow profiles caused by a variety of breathing patterns also requires further study, and the use of such techniques with selected inhaled particle size holds promise in possible diagnostic aid in diagnosis of normal versus disease conditions. Mechanisms of conducting airway and alveolar clearance processes involving mucociliary clearance, dissolution, transport to systemic circulation, and translocation via regional lymphatic clearance are discussed. The roles of the pulmonary macrophage in airway and alveolar clearance are described, and the applicability of recent solubility models for translocation or deposited materials to liver, skeleton, or other systemic organs is discussed.
Exposure to Hazardous Substances and Male Reproductive Health: A Research Framework
Authors: Jacqueline M. Moline, Anne L. Golden, Natan Bar-Chama, Ernest Smith, Molly E. Rauch, Robert E. Chapin, Sally D. Perreault, Steven M. Schrader, William A. Suk, Philip J. Landrigan
Journal: Environmental Health Perspectives (2000)

The discovery in the mid-1970s that occupational exposures to pesticides could diminish or destroy the fertility of workers sparked concern about the effects of hazardous substances on male reproductive health. More recently, there is evidence that sperm quantity and quality may have declined worldwide, that the incidence of testicular cancer has progressively increased in many countries, and that other disorders of the male reproductive tract such as hypospadias and cryptorchidism may have also increased. There is growing concern that occupational factors and environmental chemical exposures, including in utero and childhood exposures to compounds with estrogenic activity, may be correlated with these observed changes in male reproductive health and fertility. We review the evidence and methodologies that have contributed to our current understanding of environmental effects on male reproductive health and fertility and discuss the methodologic issues which confront investigators in this area. One of the greatest challenges confronting researchers in this area is assessing and comparing results from existing studies. We elaborate recommendations for future research. Researchers in the field of male reproductive health should continue working to prioritize hazardous substances; elucidate the magnitude of male reproductive health effects, particularly in the areas of testicular cancer, hypospadias, and cryptorchidism; develop biomarkers of exposure to reproductive toxins and of reproductive health effects for research and clinical use; foster collaborative interdisciplinary research; and recognize the importance of standardized laboratory methods and sample archiving.
The survivors of cardiac arrest. A psychiatric study
Authors: R. G. Druss
Journal: JAMA (1967)

Ten survivors of a cardiac arrest who had been treated in a cardiac monitor unit were studied by psychiatric interviews six weeks or more after arrest. Not a single patient could face the full implications of the arrest and called forth various defense mechanisms to control the anxiety evoked by this experience. Frightening and violent dreams belied their often tranquil appearance. The patients developed various theories and explanations to enable them to integrate the experience of "having been dead and reborn." The arrest survivors as well as ten comparative patients without arrest who had been treated in the same monitor unit showed long-standing emotional problems including insomnia, irritability, and a restriction of their activities often beyond what was medically appropriate.