tbuckley/cabot-search huggingface dataset:
A phase I study of oral administration of MGCD265 in patients with advanced malignancies (study 265-102).
Authors: E. I. Heath, P. LoRusso, R. Kurzrock, G. S. Falchook, C. R. Maroun, M. A. Drouin, M. Juretic, R. E. Martell, J. M. Besterman, J. J. Wheler
Journal: Journal of Clinical Oncology (2010)

3108 Background: MGCD265 targets the Met, VEGFR-1, 2, 3, Ron and Tie-2 tyrosine kinases, which play key roles in tumor development. Methods: This is an open-label, dose escalation study of oral MGCD265 administered once daily on a 1 week on/1 week off schedule of each 28-day cycle. The starting dose was 24 mg/m2 with doubling of dose between cohorts if no grade 2 drug-related toxicity or dose-limiting toxicities (DLT) are observed. Results: The first 20 patients recruited received the capsule formulation of MGCD265 (4 patients at 24 mg/m2, 4 patients at 48 mg/m2, 3 patients at 96 mg/m2, 3 patients at 192 mg/m2, 3 patients at 255 mg/m2, and 3 patients at 340 mg/m2). A tablet formulation was recently introduced and 8 additional patients have been recruited using this formulation: 4 patients at 192 mg/m2and 4 patients at 255 mg/m2. No DLTs have been observed to date but grade 2 adverse events considered at least possibly related to the treatment included diarrhea, nausea, neutropenia, and intermittent dizziness. To date, 7 patients have experienced stable disease per RECIST. One patient (at 96 mg/m2) with sarcomatoid bladder cancer was stable for 10 cycles with significant pharmacodynamic changes in Met and phospho-Met proteins, as well as a decrease in intact vascular structures, in a post-treatment biopsy sample. The preliminary pharmacokinetic (PK) analysis demonstrates a linear exposure up to 192 mg/m2. At this dose, the PK profile from tablets and capsules appears similar. The PK determination above 192 mg/m2 is in progress. At 192 mg/m2, the steady state plasma concentration is in the range of the exposure at an efficacious dose in xenograft models of Met sensitive tumors. Conclusions: To date, intermittent administration of MGCD265 was found to be well tolerated. Early signs of clinical activity and PD changes have been demonstrated and at 192 mg/m2, the human exposure is in the range of an efficacious dose in preclinical Met sensitive models. In the absence of significant toxicity, this dose could be considered a phase II dose. Author Disclosure Employment or Leadership Position Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration MethylGene MethylGene MethylGene MethylGene
Quarterly Report to the Domestic Policy Council on the Prevalence and Rate of Spread of HIV and AIDS in the United States
Journal: JAMA (1988)

This report includes trends in reported cases of AIDS; trends in prevalence and incidence of Human Immunodeficiency Virus Type 1 (HIV-1) infection; status of HIV-1 antibody surveys; data on HIV-2; and a comparison of AIDS mortality and years of potential life lost (YPLL) with other major diseases. By March 14, 1988, a total of 56,212 cases of AIDS had been reported in the US; nearly 10,000 of these cases have been reported since the last report, on November 30, 1987. More than 31,400 cases have resulted in death. The 416 cases of AIDS reported during the past 12 months among children under 13 years of age represent an 85% increase over the total for the previous year; 75% of these children acquired their infection perinatally, probably before birth, from their infected mothers. Accurate estimates of the prevalence and rate of spread of HIV-1 infection in the entire US population are not possible at this time. More precise estimates are available only for certain subgroups of the general population such as blood donors and applicants for military service. Among active-duty US Army personnel who have been tested more than once, 7.7/10,000/year have become infected since their 1st test. The 1st reported case of AIDS caused by HIV-2 in the US was diagnosed in December 1987. The patient was a recent visitor from West Africa, where HIV-2 was originally described, and denied sexual intercourse, use of nonsterile needles, or donation of blood while in the US.
Cardiac Pacemakers
Authors: Bruce J. Walz
Journal: JAMA (1975)

Representative demand cardiac pacemakers were tested with several common radiation therapy devices and ancillary equipment. The experimental set-up essentially duplicated the dosimetric and electroconductive environment of the radiation therapy patient bearing a pacemaker. Observations of pulse width and interval confirmed that pacemaker output was generally not appreciably affected by the simulated treatments. Occasionally, changes were caused by ancillary equipment and start-up of treatment. We conclude that although interference hazards are sometimes seen, radiation therapy is not contraindicated in patients wearing pacemakers. (<i>JAMA</i>234:72-73, 1975)
The Impact of NOD2/CARD15 and KIR Polymorphisms on the Incidence of Infectious Complications in allo-HSCT Recipients.
Authors: Aleksandra Holowiecka-Goral, Sebastian Giebel, Izabela Nowak, Tomasz Czerw, Jerzy Wojnar, Malgorzata Krawczyk-Kulis, Elzbieta Pietruszka, Miroslaw Markiewicz, Piotr Kusnierczyk, Iwona Wylezol, Jerzy Holowiecki Prof
Journal: Blood (2007)
Abel Ayerza (1861-1918)
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Contents
Authors: J Zhou, L Lu, M.-F Yuen, T.-W Lam, C.-P Chung, C.-L Lam, B Zhang, S Wang, Y Chen, S Wu, V Poon, F Ng, C Chan, S Jiang, K.-Y Yuen, B.-J Zheng, A Iacobellis, M Siciliano, F Perri, B Annicchiarico, G Leandro, N Caruso, L Accadia, G Bombardieri, A Andriulli
Journal: Journal of Hepatology (2006)
Transactions of the Colorado State Medical Society, at its Thirteenth Annual Convention held in Denver, June, 1883.
Journal: JAMA (1883)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Understanding tendinopathies
Authors: A Scott, V Duronio
Journal: British Journal of Sports Medicine (2003)

When two musical notes with simple frequency ratios are played simultaneously, the resulting musical chord is pleasing and evokes a sense of resolution or “consonance”. Complex frequency ratios, on the other hand, evoke feelings of tension or “dissonance”. Consonance and dissonance form the basis of harmony, a central component of Western music. In earlier work, we provided evidence that consonance perception is based on neural temporal coding in the brainstem (Bones et al., 2014). Here, we show that for listeners with clinically normal hearing, aging is associated with a decline in both the perceptual distinction and the distinctiveness of the neural representations of different categories of two-note chords. Compared with younger listeners, older listeners rated consonant chords as less pleasant and dissonant chords as more pleasant. Older listeners also had less distinct neural representations of consonant and dissonant chords as measured using a Neural Consonance Index derived from the electrophysiological “frequency-following response.” The results withstood a control for the effect of age on general affect, suggesting that different mechanisms are responsible for the perceived pleasantness of musical chords and affective voices and that, for listeners with clinically normal hearing, age-related differences in consonance perception are likely to be related to differences in neural temporal coding.
Obituary Listing
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Incorrect order of authors' names
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The British Pharmacopoeia 1932.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Shoe
Authors: Jack Coulehan
Journal: Annals of Internal Medicine (1998)

Ad Libitum15 April 1998The ShoeJack Coulehan, MDJack Coulehan, MDSetauket, NY 11733Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-8-199804150-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail important work to do. ... Author, Article, and Disclosure InformationAffiliations: Setauket, NY 11733 Previousarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 April 1998Volume 128, Issue 8Page: 690KeywordsPrevention, policy, and public healthRiversShoulders ePublished: 15 August 2000 Issue Published: 15 April 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
MEDICAL LEGISLATION.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 3758: Targeting ovarian cancer induced peritoneal carcinomatosis by inhibition of signaling axis between Interleukin-6 (IL-6) and serine protease inhibitor Kazal type 1 (SPINK1)
Authors: Christine Mehner, Erin Miller, Mathew A. Coban, Alexandra Hockla, Derek C. Radisky, Evette S. Radisky
Journal: Cancer Research (2019)

Abstract Ovarian cancer remains a challenging disease, with an average 5 year survival rate of 46%. At time of diagnosis, over 70% of patients have advanced metastatic disease, for which there are no effective treatment options. Of patients with metastatic disease, more than 70% of patients develop peritoneal carcinomatosis, making the peritoneum one of the main areas of dissemination. We have previously found that expression of the serine protease inhibitor Kazal type 1 (SPINK1) by ovarian cancer cells drives anoikis resistance, allowing the tumor cells to circumvent apoptosis protocols and facilitating tumor cell metastasis. For this new study we focused on ovarian clear cell carcinoma (OCCC), a histotype of ovarian cancer that has particularly poor prognosis if diagnosed in late stage. Using OCCC cell lines, we found that knockdown of SPINK1 reduces cell survival and stimulates apoptotic pathways in OCCC cells, when cultured under attachment-free conditions to mimic metastatic disease. We then identified Interleukin-6 (IL-6) as an upstream regulator of SPINK1 expression and a potential therapeutic target for metastatic OCCC: we showed that IL-6 silencing reduced SPINK1 mRNA expression and cell survival, while treatment with recombinant IL-6 increased SPINK1 expression and attachment-free survival. We developed a new OCCC mouse model and showed that knockdown of SPINK1 results in significant reduction of metastatic lesions, highlighting the impact of SPINK1 on OCCC metastasis. In ongoing studies we are testing intraperitoneal injections of FDA approved IL-6 inhibitors in a preclinical model to assess impact on abdominal dissemination of tumor cells. By targeting the IL-6 – SPINK1 signaling axis, we aim to develop therapeutic approaches to reduce the metastatic burden and peritoneal carcinomatosis of late stage disease, resulting in better prognosis and survival of patients with ovarian clear cell carcinoma. Citation Format: Christine Mehner, Erin Miller, Mathew A. Coban, Alexandra Hockla, Derek C. Radisky, Evette S. Radisky. Targeting ovarian cancer induced peritoneal carcinomatosis by inhibition of signaling axis between Interleukin-6 (IL-6) and serine protease inhibitor Kazal type 1 (SPINK1) [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3758.
Contagious Pneumonia
Authors: W. Bruce
Journal: BMJ (1886)

A'.I," .\~'.~?" 55 7 ~" L " l?'.aid small beasts of thirty-four different varieties, according to a care- fal report of Dr. Alfred Hill, published some few years ago.The only point remaining, and worthy of further allusion, is that all the conclusions formulated by Sir Spencer Wells in 1878, based on his own experience, have, without exception, been reversed by the statistics freed from his heavy mortality.One of.hisconclusions was a very serious one, for it hampered progress very much, especially in operations for removal of the uterine appendages.It was to the effect that remnovai of two ovaries was a far more fatal operation than removal of one.This conclusion ought to have been, that two pedicles in a clamp were far more risky titan one; now it is evident that it is in no way more risky to remove two ovaries for cystoma, or anything else, than to remove one.In connection with this point, it may be as well to say that, in the period embracing this series of 139 successful cases, there has not been in my practice a single incomplete operation.Now that we have cleared away all our superstitions, and view the facts in a more reasonable light, we see this operation of ovariotomy not only the most successful achievement in surgery, but we have to regard it as a portal, which, opened within the last eight years, has led to innumerable other blessings to suffering humanity.
ROBERT HOOKE (1635-1703)— MASTER INVENTOR
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Michael Servetus
Authors: William A. R. Chapin
Journal: New England Journal of Medicine (1959)

ON a hillside to the south of the town of Geneva, commanding a fair view of the valley of the Rhone and the ancient city, there is a spot the old citizens remember as the "hangman's lot," the precise place now covered by a house. Between the house and the road is a small, brown, ancient, weather-beaten marker to a man christened Michael Servetus, a practicing physician of his time. I visited this spot and saw this marker a year ago and would sketch briefly the events and portents of this marked man's life.Servetus was a rebel in every . . .
Intra-arterial and Intracavity Chemotherapy Conference
Journal: JNCI Journal of the National Cancer Institute (1983)

Intra-arterial and Intracavity Chemotherapy Conference Get access JNCI: Journal of the National Cancer Institute, Volume 71, Issue 4, October 1983, Page 877, https://doi.org/10.1093/jnci/71.4.877-a Published: 01 October 1983
Basic Science Education Called Problem for Medical Schools
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal