tbuckley/cabot-search huggingface dataset:
CARAMEL study: ClinicAl prognostic biomarkers for Ipilimumab-Related outcome in metastatic MELanoma patients
Authors: L. ORGIANO, F. Bruder, C. Madeddu, R. Marconcini, E. Gambale, E. Galizia, S. Stucci, F. Spagnolo, L. Di Guardo, C. Loi, F. Pani, D. Massa, E. Massa, G. Astara, M. Del Vecchio, F. Silvestris, M. De Tursi, A. Falcone, P. Queirolo, M. Scartozzi
Journal: Annals of Oncology (2016)
BUDAPEST
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Williams Textbook of Endocrinology
Authors: Sheldon S. Stoffer
Journal: JAMA (1987)

The great Dr Robert Hardin Williams died in 1979. This edition of his classic textbook is the first edited by Wilson and Foster. In the tradition of previous editions contributors have been selected who are at the forefront of endocrinology, and each chapter is followed by an extensive bibliography. I would feel remiss as an endocrinologist if I did not buy the latest edition of this text as soon as it became available. However, as in previous editions, this book occasionally suffers from some disorganization and at times lacks a proper clinical focus. Important clinical topics are not always given the space and emphasis they deserve. The introduction of the outpatient thyroid biopsy has been one of the most important events in thyroidology in the last 25 years. Unbelievably, there is only one half page devoted to thyroid biopsy. The topic of hirsutism was imbedded in chapter 9, "Disorders of
153P Ramucirumab safety in East Asian (EA) compared to non-EA patients: A meta-analysis of adverse events (AEs) in 6 global, randomized, double-blind, phase 3 clinical trials
Authors: H.C. Chung, Y. Chao, K-W. Lee, M. Kudo, C-J. Yen, T.W. Kim, K. Yamazaki, J-Y. Shih, S-W. Kim, J-H. Sohn, R. Cheng, Y. Zhang, P. Binder, G. Mi, M. Orlando, K. Muro
Journal: Annals of Oncology (2016)
Book Review A Text-Book of Gynecology . By Arthur Hale Curtis, M.D., Professor and Head of the Department of Obstetrics &amp; Gynecology, Northwestern University Medical School; Chief of the Gynecological Service, Passavant Memorial Hospital, Chicago. 380 pages with 222 original illustrations. Philadelphia and London; W. B. Saunders Co., 1930. Cloth $5.00.
Journal: New England Journal of Medicine (1930)
Current Issues in Pediatric Oncology Nursing
Journal: JNCI Journal of the National Cancer Institute (1979)

Journal Article Current Issues in Pediatric Oncology Nursing Get access JNCI: Journal of the National Cancer Institute, Volume 63, Issue 2, August 1979, Page 533, https://doi.org/10.1093/jnci/63.2.533-a Published: 01 August 1979
Error in Funding Statement
Authors: Yuri Nikiforov
Journal: JAMA Oncology (2016)

evaluate for tumor invasion and prevent possible progression of NIFTP to invasive EFVPTC.The Letter by Pradeep contributes to this discussion, stressing that patients with suspected NIFTP need to undergo lobectomy or hemithyroidectomy to rule out invasion.Regarding the author's questions, histologic criteria for NIFTP, including the exclusion criteria such as less than 1% papillae and greater than 30% solid growth, were introduced after careful review of 268 cases in order to prevent diagnosing true cancers as NIFTP.The reported study was conducted by a multidisciplinary group of physicians and scientists using histopathological and follow-up data collected on a series of 109 NIFTP cases, but we agree that further studies are required to fully define clinical management of these patients.
脱发的在线同伴支持经验
Authors: L.L. Iliffe, A.R. Thompson
Journal: British Journal of Dermatology (2019)

患者及其家人会发现,与其他患者分享他们的故事会很有帮助。在线群组对于那些对自己的模样害羞或不自然的人特别有用。Alopecia UK 是一个为脱发患者提供支持的群组。他们的网站链接到仅限成员进入的受监控的 Facebook 群组。 关于皮肤病在线支持的获益的研究还很少,因此,这些来自英国谢菲尔德的心理学家采访了 12 位受 Alopecia UK Facebook 群组帮助的患者。 这类研究的常用方法是“内容分析”,即对患者访谈进行分析以识别主题。 这些研究人员使用了“解释性现象学分析”。首先,他们要求参与者提供他们认为特别有用的帖子的屏幕截图。然后,他们询问有关患者对网站和屏幕截图的体验的一系列问题。最终,他们分析了访谈内容以寻找个人和群组表达的主题。 参与者(均为女性)描述了在线论坛如何使其摆脱痛苦感和缺乏吸引力的感受,分享如何处理外表的实用技巧,减少孤独感和增加正常感受,并使其更能接受自己的外表和对社交更有信心。一些人报告了无帮助的评论和不准确的建议。 该研究表明,在线同伴支持可以通过将患者与一个安全私密的社区联系起来,从而鼓励他们适应慢性(长期)疾病。这样的平台可以与其他疗法结合使用。
Phase II Trial of Doxorubicin and Docetaxel Plus Granulocyte Colony-Stimulating Factor in Metastatic Breast Cancer: Eastern Cooperative Oncology Group Study E1196
Authors: Joseph A. Sparano, Anne O’Neill, Paul L. Schaefer, Carla I. Falkson, William C. Wood
Journal: Journal of Clinical Oncology (2000)

PURPOSE: The purpose of this multi-institutional phase II trial was to evaluate the efficacy and toxicity of doxorubicin and docetaxel plus granulocyte colony-stimulating factor (G-CSF) in patients with metastatic breast cancer. The primary objective was to determine whether the combination produced a response rate of at least 50%. PATIENTS AND METHODS: Fifty-four patients with metastatic breast cancer received doxorubicin (60 mg/m 2 by intravenous [IV] injection) followed 1 hour later by docetaxel (60 mg/m 2 by IV infusion over 1 hour) every 3 weeks for up to eight cycles. All patients also received G-CSF. RESULTS: Objective response occurred in 29 (57%) of 51 eligible patients (95% confidence interval [CI], 42% to 70%), including three patients who had a complete response (6%; 95% CI, 1% to 16%). The median response duration was 7 months (95% CI, 6.0 to 15.0 months), median time to treatment failure was 7.6 months (95% CI, 6.2 to 9.9 months), and the median survival was 27.5 months (95% CI, 21.5 months to upper limit not reached). The median cumulative doxorubicin dose was 395 mg/m 2 (range, 60 to 480 mg/m 2 ). Fifteen patients (28%) were documented to have a decrease in the left ventricular ejection fraction below normal, and three patients (6%; 95% CI, 1% to 15%) developed congestive heart failure. CONCLUSION: Using criteria that we had defined a priori, the doxorubicin-docetaxel regimen as used in this study was sufficiently active and tolerable to justify a phase III comparison with doxorubicin-cyclophosphamide in early-stage breast cancer.
THE CHOLERA.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Salt Restriction
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Acknowledgment.
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Human Hemoglobins in Health and Disease
Authors: Amoz I. Chernoff
Journal: New England Journal of Medicine (1955)

Mixed Heterozygous Hemoglobin DiseasesTwo and possibly three hemolytic diseases are now recognized that fall into the group of mixed heterozygous hemoglobin diseases. The genetic mechanism involved in the heredity of this group is schematically portrayed in Figure 12. Each patient transmits the gene for a different hemoglobin. Some of the children of such a mating will therefore be heterozygous for each of the two abnormal hemoglobins.The most important disease in this group is sickle cell-Hgb G disease, in which the patient is heterozygous for Hgb S and Hgb C.8,11,56,76,78,79,92,94,105,106,110,180,206,213, 217 This disease waS first suspected in patients with atypical sickle-cell anemia . . .
Medical examination for health of all athletes replacing the need for gender verification in international sports. The International Amateur Athletic Federation Plan
Authors: A. Ljungqvist
Journal: JAMA (1992)

FOR DECADES, success in competitive international sports has been fostered to promote national prestige and even to support superiority of certain political systems. (The former German Democratic Republic is but one prominent example of a nation in which high-level competitive sports were explicitly chosen as a vehicle to enhance a newly formed nation's identity. Other countries naturally sought to meet the competition; thus, a quasi "arms race" in sports developed.) Given the great national prestige engendered and the considerable expenditures involved in international competitive sports, it is not surprising that individual athletes or even nations were unable to resist the temptation of using illicit methods to "win at all costs." One prominent example of cheating is doping, usually with drugs. Another type of cheating, namely, the possibility that men may masquerade as women in women's events, was widely discussed in the early 1960s. For editorial comment see p 853. To
The air cholangiogram as an unusual sequela to thoracocentesis
Authors: E. Perlin
Journal: JAMA (1969)

During an attempted thoracocentesis in a patient with empyema, air was inadventently introduced beneath the diaphragm apparently penetrating the liver capsule. Air filled the biliary tree and 24 hours later, an "air cholangiogram" was seen roentgenographically. Transient liver function abnormalities followed the incident.
NEOMYCIN-RESISTANT STAPHYLOCOCCI IN OUTPATIENTS
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Increase in the Systolic Pressure of Rats Chronically Fed Cadmium
Authors: H. Mitchell Perry, Margaret Erlanger, Elizabeth F. Perry
Journal: Environmental Health Perspectives (1979)

In our laboratory, chronically feeding cadmium to groups of rats has been reproducibly associated with average increases of 15 to 20 mm Hg in systolic pressure. A total of 497 female Long-Evans rats were continuously provided with drinking water fortified with five essential elements and containing from 0.01 to 50 ppm cadmium, as the acetate, from weaning for as long as 30 months. These rats, plus 311 matched control animals which received fortified water without added cadmium, were fed a special low-cadmium diet. All 808 rats were weighed at least monthly as a screen for cadmium toxicity, and their systolic pressures were measured every 3 or 6 months. The two lowest concentrations of cadmium tested (0.01 and 0.03 ppm) were not pressor; the three highest concentrations (10, 25, and 50 ppm) ultimately proved to be toxic. All indirect systolic pressures (each measured in triplicate) of all rats which received 0.1 to 5 ppm cadmium (i.e., nontoxic pressor doses) averaged 15.0 mm Hg more than simultaneously measured pressures of control rats. This average increase over the control pressure is extremely significant statistically, even though it seems relatively small in absolute terms. Occasionally, however, some rats had much larger than average increases in pressure; thus, 10 of 60 rats receiving from 0.1 to 0.5 ppm cadmium for 18 months had systolic pressures that were more than 50 mm Hg above the average pressure of the control rats. Cadmium-induced hypertension is not limited to females or to a particular strain. Although we have usually used one strain of female Long-Evans rat from a single source, males of the same strain and female Sprague-Dawley rats have also developed comparable hypertension. All subgroup II elements can apparently induce similar increases in systolic pressure averaging 15 to 20 mm Hg, but cadmium is pressor in much smaller amounts than mercury or zinc. Thus, to induce a demonstrable increase in pressure requires more than ten times as much divalent mercuric ion as cadmium and more than 1000 times as much zinc as cadmium. Exposure to another metal along with cadmium can markedly alter the ability of cadmium to induce hypertension. Selenium protects against the hypertension induced by twice as much cadmium. Large excesses of both zinc and copper have also inhibited the induction of hypertension by cadmium. In contrast, lead, which like cadmium, can also induce hypertension, augments rather than inhibits cadmium-induced hypertension; thus, lead and cadmium together can induce an average increase in systolic pressure in excess of 40 mm Hg, at least twice as large as is usually induced by either metal alone.
Efficacy of grass pollen sublingual immunotherapy for three consecutive seasons and after cessation of treatment: the ECRIT study
Authors: H. Ott, J. Sieber, R. Brehler, R. Fölster‐Holst, A. Kapp, L. Klimek, O. Pfaar, H. Merk
Journal: Allergy (2009)

Background: Data supporting a carry‐over effect with sublingual immunotherapy (SLIT) are scarce. This randomized, double‐blind, placebo‐controlled study evaluated the efficacy, carry‐over effect and safety of grass pollen SLIT using co‐seasonal treatment. Methods: Patients (7.9–64.7 years) with grass pollen allergy received ultra‐rush titration with increasing doses (30, 90, 150 and 300 IR) of a 5‐grass pollen mixture every 20 min at the start of the pollen seasons, followed by 300 IR daily until the end of the pollen seasons. A baseline season (no SLIT) was followed by three consecutive treatment seasons and one follow‐up season. Symptoms, medication and adverse events were documented and specific immunoglobulin (Ig)E and IgG 4 measured. Results: Data were analysed for 183 of the 213 randomized patients. Mean treatment duration varied between seasons (81.8−92.7 days). Combined scores (symptoms and medication) improved progressively across treatment seasons (up to 44.7% improvement for SLIT compared with baseline) and fluctuated between −11.3% and −14.8% for placebo ( P &lt; 0.05). Similar changes were observed for symptom scores, with a successive decrease of 39.7% (SLIT) and fluctuations between +13.6% and −1.51% for placebo ( P &lt; 0.05). Combined score ( P = 0.0508) and symptom score improvements ( P = 0.0144) with SLIT continued during follow up. Increases in specific IgG 4 observed in the first season were sustained for SLIT vs placebo throughout treatment ( P = 0.0001). Titration and daily SLIT were well tolerated. No serious systemic or anaphylactic reactions were reported. Conclusions: Seasonal SLIT with ultra‐rush titration is well tolerated and effective from the first treatment season onwards. These data indicate a carry‐over effect of seasonal SLIT.
Manual of Serum Diagnosis.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Social Medicine
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Episodes of High Coarse Particle Concentrations Are Not Associated with Increased Mortality
Authors: Joel Schwartz, Gary Norris, Tim Larson, Lianne Sheppard, Candis Claiborne, Jane Koenig
Journal: Environmental Health Perspectives (1999)

Fine particle concentration (i.e., particles <2.5 microm in aerodynamic diameter; PM2.5), but not coarse particle concentration, was associated with increased mortality in six U.S. cities. Others criticized this result, arguing that it could result from differences in measurement error between the two size ranges. Fine particles are primarily from combustion of fossil fuel, whereras coarse particles (i.e., particles between 2.5 and 10 microm in aerodynamic diameter) are all crustal material, i.e., dust. One way to determine if coarse particles are a risk for mortality is to identify episodes of high concentrations of coarse, but not fine, particles. Spokane, Washington, is located in an arid area and is subject to occasional dust storms after crops have been harvested. Between 1989 and 1995, we identified 17 dust storms in Spokane. The 24-hr mean PM10 concentration during those storms was 263 microg/m3. Using control dates that were the same day of the year in other years (but with no dust storm on that day) and that had a mean PM10 concentration of 42 microg/m3, we compared the rate of nonaccidental deaths on the episode versus nonepisode days. There was little evidence of any risk [relative risk (RR) = 1.00; 95% confidence interval (CI), 0.81-1.22] on the episode days. Defining episode deaths as those occurring on the same or following day as the dust storm produced similar results (RR = 1.01; CI, 0.87-1.17). Sensitivity analyses, which tested more extensive seasonal control, produced smaller estimates. We conclude that coarse particles from windblown dust are not associated with mortality risk.