tbuckley/cabot-search huggingface dataset:
Abstract 26: Assessing and Refining Cardiovascular Disease Risk Estimation Among Patients with Human Immunodeficiency Virus: Center for Acquired Immunodeficiency Syndrome Research Network of Integrated Clinical Systems
Authors: Matthew J Feinstein, Daniel R Drozd, Hongyan Ning, Joseph A Delaney, Robin Nance, William C Mathews, Mari Kitahata, Michael Saag, Joseph Eron, Richard Moore, Chad J Achenbach, Heidi Crane, Donald M Lloyd-Jones
Journal: Circulation (2016)

Background: Persons living with human immunodeficiency virus (HIV) have greater risks for myocardial infarction (MI) than uninfected persons. These elevated MI risks, which are associated with both traditional and HIV-specific risk factors, may limit the applicability of cardiovascular risk prediction models for HIV-infected persons. Methods: We evaluated the ACC/AHA atherosclerotic cardiovascular disease (ASCVD) Risk Estimator’s Pooled Cohort Equations (PCEs) and a new model incorporating HIV-specific variables using the Centers for AIDS Research (CFAR) Network of Integrated Clinical Systems (CNICS) multi-center U.S.-based cohort of HIV-infected adults. CNICS has rigorous central adjudication of type I and II myocardial infarction (MI), which may be distributed differently in HIV-infected versus uninfected populations. Because adjudicated stroke data were not available, ASCVD risks predicted by the PCEs were scaled to determine predicted MI rates using race-sex-specific proportions. MI rates predicted by the PCEs and the new model were compared with observed MI rates in CNICS. Harrell’s C-statistic and Hosmer-Lemeshow chi-square were used to determine discrimination and calibration of these models. Results: Of 11,901 HIV-infected persons in CNICS with baseline data required for the PCEs, 180 experienced MIs over a mean follow-up of 4.3 years. The PCEs were poorly calibrated for white men and black women (Hosmer-Lemeshow chi-square = 25.3 and 42.9, respectively) and had inadequate discrimination for black men (Harrell’s C statistic = 0.65). A modified, data-derived model had excellent discrimination (Harrell’s C-statistic for men = 0.81; for women = 0.83) and was well calibrated (Figure). Conclusions: A data-derived ASCVD risk estimator that incorporates HIV-specific coefficients had excellent discrimination and calibration in a large multi-center U.S. HIV cohort. Future studies are needed to validate this model in other HIV cohorts and evaluate the contributions of type I versus II MI to ASCVD risk.
BOOK REVIEW
Authors: W. STETLER-STEVENSON
Journal: JNCI Journal of the National Cancer Institute (1993)

Journal Article BOOK REVIEW Get access Metastasis: Basic Research and Its Clinical Applications , H. Rabes , P. E. Peters , K. Munk , eds. New York : S. Karger , 1992 . 393 pp., illus. $63.25. ISBN 3-8055-5610-1 WILLIAM STETLER-STEVENSON, M.D., PH.D. WILLIAM STETLER-STEVENSON, M.D., PH.D. National Cancer Institute, National Institutes of HealthBldg. 10, Rm. 2A33, 9000 Rockville Pike, Bethesda, MD 20892 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 85, Issue 14, 21 July 1993, Page 1165, https://doi.org/10.1093/jnci/85.14.1165 Published: 21 July 1993
Nephritogenic Streptococci
Authors: J C Johnson, G H Stollerman
Journal: Annual Review of Medicine (1969)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease 2019 (COVID-19), emerged in China in December 2019 and quickly spread around the globe, killing more than 4 million people and causing a severe economic crisis. ...Read More
END-RESULTS OF PRENATAL CARE
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hypercoagulability in patients with Primary Biliary Cirrhosis (PBC) and Primary Sclerosing Cholangids (PSC) evaluated by thromboelastography Z Ben-Ari, M Panagou, D Patch, S Bates, E Osman, AK Burroughs. Hepatobiliary and Liver Transplantation Unit, and 'Department of Anaesthesia, Royal Free Hospital, Pond Street, LONDON UK.
Journal: Hepatology (1995)
Phase II study of daratumumab (DARA) monotherapy in patients with ≥ 3 lines of prior therapy or double refractory multiple myeloma (MM): 54767414MMY2002 (Sirius).
Authors: Sagar Lonial, Brendan M. Weiss, Saad Zafar Usmani, Seema Singhal, Ajai Chari, Nizar J. Bahlis, Andrew Belch, Amrita Y. Krishnan, Robert A. Vescio, María-Victoria Mateos, Amitabha Mazumder, Robert Z. Orlowski, Heather J Sutherland, Joan Blade, Emma Catherine Scott, Huaibao Feng, Imran Khan, Clarissa M. Uhlar, Tahamtan Ahmadi, Peter Michael Voorhees
Journal: Journal of Clinical Oncology (2015)

LBA8512 The full, final text of this abstract will be available at abstracts.asco.org at 7:30 AM (EDT) on Saturday, May 30, 2015, and in the Annual Meeting Proceedings online supplement to the June 20, 2015, issue of the Journal of Clinical Oncology. Onsite at the Meeting, this abstract will be printed in the Monday edition of ASCO Daily News.
Inadvertent Myocardial Biopsy: Potential Hazard During Left Ventricular Puncture
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Oral Rotavirus Vaccines Sometimes Mistaken for Injectables
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Study Probes Burkitt Lymphoma–Malaria Link
Journal: Cancer Discovery (2015)

Burkitt lymphoma is unusually common in parts of Africa where malaria is widespread, but the reason for the association has been unclear. A new study suggests that parasitic infection triggers dramatic B-cell proliferation and increased expression of the enzyme activation-induced cytidine deaminase, which generates more potent antibodies-and causes mutations that lead to cancer.
Viral hepatitis abroad. Incidence in Catholic missionaries
Authors: R. D. Woodson
Journal: JAMA (1972)

Hepatitis incidence was studied retrospectively in a group of 1,314 Catholic missionaries living in various developing countries. Overall incidence of icteric illnesses was 1.7 cases per 100 person-years exposure. There were large differences in hepatitis incidence in the various countries, with rates varying from a low of 0.2 cases per 100 person-years in Japan to a high of 4.0 cases per 100 person-years in some countries of Central and South America. Risk was sustained at fairly high levels for at least ten years. It is suggested that the high risk warrants prophylaxis with immune serum globulin.
Human Myiasis
Authors: Michael M. Schreiber, Natalie Schuckmell, John Sampsel
Journal: JAMA (1964)

HUMAN MYIASIS is common in the tropics, but rare in temperate zones. Thus the occurrence of three cases of myiasis (two cutaneous and one tonsillar) during a two-month period of Tucson, Ariz, made this report seem justified. <h3>Report of Cases</h3><h3>Case 1 (Fig 1 and 2).—</h3> A 1-year-old girl with a pyoderma of her scalp had three maggots in her right ear and 25 from tumid masses behind the ear removed with forceps. More maggots were removed from deep sinus tracts extending into the outer table of her skull at surgery. A complete blood count, cerebrospinal fluid, and x-rays of the skull were all normal. The maggots were identified as<i>Cochliomyia americana</i>(American screwworm) larvae. <h3>Case 2.—</h3> A 51-year-old man, following an episode of coughing up maggots, was found to have a 2- to 3-mm perforation of the hard palate, edema and thickening of both tonsillar fauces, and pillars which
Benign hemoglobinuria following transfusion of accidentally frozen blood
Authors: S. G. Sandler
Journal: JAMA (1976)

A patient was transfused with a unit of red blood cells that had been frozen accidentally prior to transfusion. Although he had received approximately 60 gm of free hemoglobin intravenously, the patient's only clinical reaction was massive hemoglobinuria. The benign clinical response, in the presence of massive hemoglobinuria, is attributed to the absence of immunologic incompatibility and, thus, failure to activate vasoactive mediators and disseminated intravascular coagulation. The case illustrates revised concepts of the pathophysiology of acute renal failure associated with hemolytic blood transfusion reactions. (<i>JAMA</i>235:2850-2851, 1976)
Experts Urge Bioterrorism Readiness
Authors: B. Vastag
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Journal of Virology, Baltimore
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medical News
Journal: JAMA (1970)

<h3>Trials of electroanesthesia are continuing, but...</h3> 'Since 1875, we have been trying to produce a clinically useful electroanesthesia and have met with little success' One of the largest recent clinical trials of electroanesthesia was reported in Las Vegas during the Third Annual Neuroelectric Conference. Data accumulated during 250 operations ranging from tonsillectomies to perineal procedures were presented by three anesthesiologists from the Indian Army. However, Brigadier K. R. Rama Rao, MB, BS, and his colleagues were unable to attend in person and their paper was read by Norman L. Wulfsohn, MD, chairman of the meeting's clinical sessions. According to the Indian physicians, 86.8% of the patients remained quiet, did not display any reflex responses or purposeful movement, could not remember intraoperative events, and otherwise seemed to represent successful uses of this technique. Another 10% of the operations were termed partial successes because the patients responded to pull, pressures, or sounds,
RICHARD WISEMAN—SEVENTEENTH CENTURY SURGEON
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pressure ulcers
Authors: Joseph E Grey, Keith G Harding, Stuart Enoch
Journal: BMJ (2006)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following Pressure ulcers Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Syphilis
Authors: G. Marshall Crawford
Journal: New England Journal of Medicine (1949)

Serologic Response A prolonged follow-up study of the pattern of serologic response after penicillin therapy for early syphilis is of utmost importance. A monthly quantitative test is desirable in all cases and should be performed for probably not less than a year. The quantitative determination of reagin titer at monthly intervals will enable the practicing physician correctly to assay the response to treatment and should warn him of an impending relapse before it becomes clinically manifest. In early syphilis adequate therapy with penicillin will usually reverse positive serologic tests to negative in about six months.74 Some patients, especially in the . . .
Hypotensive treatment.
Authors: E. Montuschi
Journal: BMJ (1969)

tested, but not justifiable that the best be condemned for the performance of the worst.It is true that some of the most publicized trials have been statistically flawed because of high rates of " loss to follow-up," but the reservations this should occasion in our assessment of their results are by no means so sweeping as Dr. Hawkins suggests.Most recent trials, conducted in developing coun- tries, have assessed results on the more correct basis of sample home follow-up studies, where the probabilities of important selection factors in untraced patients is very much lower than in consulting-room studies.These trials have yielded results in all ways comparable to those of Tietze's co-operative statistical programme.'While not necessarily the last word, the W.H.O.Scientific Group statement on infec- tion,2 " in general, pelvic infection is not a significant problem," represents an informed judgement of the information available in 1968.Incidences of pelvic inflammatory disease " up to 8% " are found only in studies where incidences of this order occur even in the absence of I.U.D.s or when extremely dubious definitions of inflammatory disease are used.The same consideration applies to menstrual disorder, where the incidence depends almost wholly on the criteria of definitiorr employed.Minor menstrual changes, especially increased flow, are un- deniably extremely common, especially in the first months of use.In assessing the safety and acceptability of I.U.D.s, our attention must be confined to the severe or persistent disturbances.
Editor's Choice
Journal: British Journal of Dermatology (2019)

Early detection of skin cancer by skin self-examination: a systematic reviewThis systematic review from the U.K. set out to analyse studies evaluating the early detection of skin cancer, using skin self-examination interventions.They found 18 relevant studies with 6836 participants.Meta-analysis demonstrated the impact of the intervention on the degree of skin self-examination activity from five studies, especially in the short term, but with small effect sizes.Risk-of-bias assessment indicated that 61% of the studies (n = 11) were of weak quality.This study found that some interventions can enhance skin self-examination activity and so are more likely to aid early detection of skin cancer.However, their actual clinical impact remains unclear.The authors concluded that there is a need to promote structured skin self-examination.Additionally, more theory-based interventions and rigorously designed studies are needed to evaluate the clinical impact of skin self-examination.
Herd mentality
Authors: Des Spence
Journal: BMJ (2011)

<h3>Background:</h3> The TIMI risk score is a well-validated scoring system used to predict mortality in patients following an ST-segment elevation myocardial infarction (STEMI). N-terminal pro-B-type natriuretic peptide (NTproBNP) has also been found to be useful in predicting mortality following STEMI. <h3>Objective:</h3> To investigate the utility of the TIMI score and NTproBNP levels at predicting risk of death in patients with acute myocardial infarction (AMI). <h3>Methods:</h3> 473 patients (352 men, mean (SD) age 63.7 (12.3) years) with AMI were studied. Blood was drawn within 24 hours after the onset of chest pain and the plasma concentration of NTproBNP was determined using an in-house non-competitive immunoassay. Patients’ TIMI risk score was measured and patients stratified into low- (0 to 2), intermediate- (3–7) and high-risk (&gt;8) groups. <h3>Results:</h3> Mortality was 8.9% and was related to higher TIMI risk scores (p = 0.029 for trend). Higher NTproBNP levels were also related to increased mortality (median (range) fmol/ml, survivors 700.2 (0.3–11485.3) vs dead 5781.3 (1.4–10835.9), p&lt;0.001). In a multivariate binary logistic regression model, independent predictors of mortality were NTproBNP levels in the first 24 hours (odds ratio (OR) = 4.21, 95% CI 1.96 to 9.07, p&lt;0.001) together with drug treatments. The receiver operating curve for NTproBNP in the first 24 hours yielded an area under the curve (AUC) of 0.79 (95% CI 0.70 to 0.88), p&lt;0.001, for TIMI risk score the AUC was 0.67 (95% CI 0.58 to 0.76), p = 0.001. <h3>Conclusion:</h3> In the first 24 hours following an AMI, NTproBNP is better than the TIMI risk score at predicting mortality. A simple NTproBNP blood test is more easily applicable and is more accurate than a clinical risk score.
The Diagnosis of Gastric Cancer by the Estimation of Enzyme Activity in Gastric Juice
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal