tbuckley/cabot-search huggingface dataset:
Explosion of the Apparatus in solidifying Carbonic Acid Gas
Journal: BMJ (1841)

smiled at last on the humble but assiduois cultivator of science.He became, successiively, physician at Sal- p6triere, member of the Roval Academy of Medicine, inspector-general of the univrersity, senior physician to Charenton, member of the institute, and of the board of health of Paris.Eig.ht days before his death, although seriously ill, he insisted on attending some important meet- ing of the board of health; he returned home in a state of high fever, with spitting of blood.M. Esquirol felt that his days were numbered, and prepared himself for death with chiristian fortitude.
Aspirin Use and Risk for Colorectal Adenoma
Authors: Andrew T. Chan, Charles S. Fuchs
Journal: Annals of Internal Medicine (2004)

Letters7 September 2004Aspirin Use and Risk for Colorectal AdenomaAndrew T. Chan, MD, MPH and Charles S. Fuchs, MD, MPHAndrew T. Chan, MD, MPHFrom Massachusetts General Hospital, Boston, MA 02114, and Dana-Farber Cancer Institute, Boston, MA 02115.Search for more papers by this author and Charles S. Fuchs, MD, MPHFrom Massachusetts General Hospital, Boston, MA 02114, and Dana-Farber Cancer Institute, Boston, MA 02115.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-141-5-200409070-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We appreciate Dr. Scovern's request for a clarification of our results. As we described in a footnote to our Table 4, we defined short-term use of aspirin as regular intake for no more than 5 consecutive years immediately preceding a participant's endoscopy. We did not directly examine nonconsecutive years of use or 5 years of aspirin use earlier in life. Thus, it remains unknown whether intermittent or remote aspirin use reduces risk for adenoma. However, on the basis of observed experience with nonsteroidal anti-inflammatory drugs in patients with familial polyposis (1), it appears that polyps will eventually recur ...Reference1. Giardiello FM, Hamilton SR, Krush AJ, Piantadosi S, Hylind LM, Celano P, et al . Treatment of colonic and rectal adenomas with sulindac in familial adenomatous polyposis. N Engl J Med. 1993;328:1313-6. [PMID: 8385741] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Andrew T. Chan, MD, MPH; Charles S. Fuchs, MD, MPHAffiliations: From Massachusetts General Hospital, Boston, MA 02114, and Dana-Farber Cancer Institute, Boston, MA 02115. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoA Prospective Study of Aspirin Use and the Risk for Colorectal Adenoma Andrew T. Chan , Edward L. Giovannucci , Eva S. Schernhammer , Graham A. Colditz , David J. Hunter , Walter C. Willett , and Charles S. Fuchs Aspirin Use and Risk for Colorectal Adenoma Henry Scovern Metrics 7 September 2004Volume 141, Issue 5Page: 406KeywordsAdenomasAspirinDrug therapyEndoscopy ePublished: 7 September 2004 Issue Published: 7 September 2004 Copyright & PermissionsCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
SUBJECT INDEX
Journal: Circulation Research (1967)

Acceleration, transverse, pericardia!pressure in dogs during, 65 Acetylcholine, role in renal vasoconstrictor response to sympathetic stimulation, 616 Acetylstropbanthidin, effects on cardiac sarcotubular vesicles, 599 Aconirine, tachysystole induced by, compared with electrically induced atrial flutter, 496 Action potentials change, and contractile enhancement in the myocardium, 311 interaction of quinidine and potassium on A-V conduction, 434 of Purkinje fibers, effects of calcium concentration, 32 Adenosine triphosphatase, myofibrillar, reversal of vesicular inhibition of by digitalis compounds, 599 Adenosine triphosphate enhancement of coronary vasodilator action by dipyridamole, 403 spurting, 599 Adrenal glands responses of arteriosclerotic rats to drug-induced myocardial necrosis, 78 sympatho-adrenal system in renal vasoconstrictor response to hemorrhage, 676 Adrenergic blockade, aortic and carotid chemoreceptor stimulation on ventricular performance, 214 Adrenergic nervous system, localization of nerves in cat
Erratum: HIV-1 blocks the signaling adaptor MAVS to evade antiviral host defense after sensing of abortive HIV-1 RNA by the host helicase DDX3
Authors: Sonja I Gringhuis, Nina Hertoghs, Tanja M Kaptein, Esther M Zijlstra-Willems, Ramin Sarrami-Fooroshani, Joris K Sprokholt, Nienke H van Teijlingen, Neeltje A Kootstra, Thijs Booiman, Karel A van Dort, Carla M S Ribeiro, Agata Drewniak, Teunis B H Geijtenbeek
Journal: Nature Immunology (2017)
Leiomyomas of the Skin
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Contents
Authors: R Moreau, R Bataller, T Berg, J Zucmann-Rossi, R Jalan, M Schwarzinger, S Baillot, Y Yazdanpanah, J Rehm, V Mallet, C Tho, T Senff, T Hydes, A Manser, F Heinemann, A Heinold, M Heilmann, A Kim, M Uhrberg, N Scherbaum, G Lauer, S Khakoo, J Timm, D Lenggenhager, J Gouttenoire, M Malehmir, M Bawohl, H Honcharova-Biletska, S Kreutzer, D Semela, J Neuweiler, S Hu ¨rlimann, P Aepli, M Fraga, R Sahli, L Terracciano, L Rubbia-Brandt, B Mu ¨llhaupt, C Sempoux, D Moradpour, A Weber, D Bankwitz, M Doepke, K Hueging, R Weller, J Bruening, P Behrendt, J.-Y Lee, F Vondran, M Manns, R Bartenschlager, T Pietschmann, A Tan-Garcia, L.-E Wai, D Zheng, E Ceccarello, J Jo, N Banu, A Khakpoor, A Chia, C Tham, A Tan, M Hong, C Keng, L Rivino, K Tan, K Lee, S Lim, E Newell, N Pavelka, J Chen, F Ginhoux, Q Chen, A Bertoletti, C.-A Dutertre, Q Wang, Y Lv, M Bai, Z Wang, H Liu, C He, J Niu, W Guo, B Luo, Z Yin, W Bai, H Chen, E Wang, D Xia, X Li, J Yuan, N Han, H Cai, T Li, H Xie, J Xia, J Wang, H Zhang, K Wu, D Fan, G Han, M Nadim, J Dinorcia, L Ji, S Groshen, J Levitsky, R Sung, W Kim, K Andreoni, D Mulligan, Y Genyk, S Lee, S Kim, D Sinn, C Park, J Mueller, H Raisi, V Rausch, T Peccerella, D Simons, C Ziener, H.-P Schlemmer, H Seitz, N Waldburger, T Longerich, B Straub, S Mueller, J Fioravanti, P Di, D Magini, F Moalli, C Boni, A Benechet, V Fumagalli, D Inverso, A Vecchi, A Fiocchi, S Wieland, R Purcell, C Ferrari, F Chisari, L Guidotti, M Iannacone, P Fickert, G Hirschfield, G Denk, H.-U Marschall, I Altorjay, M Fa ¨rkkila ¨, C Schramm, U Spengler, R Chapman, A Bergquist, E Schrumpf, F Nevens, P Trivedi, F Reiter, I Tornai, E Halilbasic, R Greinwald, M Pro, M Trauner, G Westwood, P Meredith, S Atkins, P Greengross, P Schmidt, R Aspinall, O Ayonrinde, W Oddy, L Adams, T Mori, L Beilin, N De Klerk, J Olynyk, -S Wong, S Petta, J.-B Hiriart, C Camma, -H Wong, F Marra, J Vergniol, -H Chan, A Tuttolomondo, W Merrouche, -Y Chan, B Le Bail, U Arena, A Craxı, V De Le ´dinghen
Journal: Journal of Hepatology (2017)
Reproductive toxicology. Primaclone.
Authors: Robert Chapin, Dushyant Gulati, Linda Grimes, Leta Barnes
Journal: Environmental Health Perspectives (1997)

Primaclone (P) is a drug used in the management of seizures in humans and dogs.Because of widespread human use, the in vivo conversion of primaclone to phenobarbital, and the lack of reproductive data in the open literature, primadone was tested for potential effects on reproduction and fertility in Swiss CD-1 mice using the RACB protocol.The dose-range-finding study (Task 1) for this study utilized a sin- gle mating trial and delivery, since the lit- erature indicated that excessive P reduced early neonatal survival.Pup survival was found to be reduced at 0.2% P.These pup data were used in conjunction with data on food and water consumptions, body weights, and clinical signs, to set exposure concentrations for the continuous cohabitation phase (Task 2) 0.015, 0.05, and 0.15% weight per volume in feed.Body weights of
Medical school admissions, specialty selection, and distribution of physicians
Authors: S. Cullison
Journal: JAMA (1976)

This review of the University of Missouri-Columbia medical graduates, with similar data from two other studies, supports the thesis that hometown size and specialty choice are interrelated predictors of the community in which physicians practice. Physicians with nonmetropolitan backgrounds were two to three times as likely to select nonmetropolitan practice as physicians with urban backgrounds. Physicians entering family medicine were almost three times as likely to select nonmetropolitan practice as physicians in other primary-care specialties. Presence of both predictors (nonmetropolitan background and selection of family medicine) resulted in two thirds selecting nonmetropolitan practice. However, selection of family medicine by graduates with urban backgrounds or selection of other specialties by graduates with nonmetropolitan backgrounds did not appreciably increase the likelihood of nonmetropolitan practice. These data have implications for medical school admissions policy and curriculum. (<i>JAMA</i>235:502-505, 1976)
Massachusetts Medical Society
Authors: John J. Hunter
Journal: New England Journal of Medicine (1964)

DEATHCattell — Richard B. Cattell, M.D., of Duxbury, died on September 16. He was in his sixty-fourth year.Dr. Cattell received his degree from Harvard Medical School in 1925. He was formerly director of the Lahey Clinic, surgeon-in-chief of the New England Baptist Hospital and a member of the staffs of the New England Deaconess, Robert Breck Brigham, Brooks and Hahnemann hospitals. He was a member of the American Medical Association. He was elected president of the American Goiter Society in 1954 and in 1958 received the "Meritorious Service Award" of the Society. He was a fellow of the . . .
A novel small molecule modulating the mitochondrial NEET (CISD) proteins activity improves inflammation and fibrosis in a diet-induced model of non-alcoholic steatohepatitis
Authors: Stéphanie Le Corre, Lines Laetitia, Sampson Diane, Karmi Ola, Margault Henri-Baptiste, Rossignol Rodrigue, Amoedo Nivea, Nechushtai Rachel, Raphaël Darteil, Jacky Vonderscher, De Chassey Benoit, Meldrum Eric
Journal: Journal of Hepatology (2020)
Abstract B2-01: Integrated omic analysis of lung cancer reveals metabolism proteome signatures with prognostic impact
Authors: Michael F. Moran, Thomas Kislinger, Lei Li, Vladimir Ignatchenko, Yuhong Wei, Christine To, Paul Taylor, Jiefei Tong, Nhu An Pham, Melania Pintilie, Lakshmi Muthuswamy, Frances A. Shepherd, Ming Sound Tsao
Journal: Cancer Research (2015)

Abstract Cancer results from processes prone to selective pressure and dysregulation acting along the sequence-to-phenotype continuum DNA→RNA→Protein→Disease. An Omics Array integrating DNA gene copy number, mRNA transcriptome, and quantified proteome was assembled into a genetic map representing non-small cell lung carcinoma (NSCLC). Data were collected from patient-matched normal lung, primary tumors, and patient tumor-derived xenograft (PDX) tumors. Dysregulated proteins not previously implicated as cancer drivers were found encoded throughout the genome including but not limited to regions of recurrent DNA amplification/deletion in NSCLC. Unsupervised clustering revealed signatures comprising metabolism proteins particularly highly recapitulated between matched primary and PDX tumors, and which distinguished between the major NSCLC histological subtypes adenocarcinoma (ADC) and squamous cell carcinoma (SCC). Interrogation of The Cancer Genome Atlas (TCGA) revealed sizeable cohorts of NSCLC patients with DNA alterations in genes encoding the metabolism proteome signatures, and accompanied by differences in survival. Similar to the proteome signatures from which they were extrapolated, the gene mutation signatures with prognostic impact discriminated between the lung ADC and SCC subtypes. Serine hydroxymethyltransferase 2 (SHMT2), a key enzyme in serine/glycine and folate-dependent one-carbon metabolism, is upregulated in the proteomes of NSCLC primary and PDX tumours, and is implicated as a driver of recurrent chromosome 12q14.1 amplification in NSCLC. SHMT2, along with other enzymes implicated as anti-folate targets, is also part of a metabolism signature associated with poor outcome in lung ADC. The interrogation of cancer genomes and proteomes for alterations that are related products of selective pressures driving the cancer phenotype may be a general approach to uncover and group together cryptic, polygenic cancer drivers, which might represent new anti-cancer therapeutic targets. Note: This abstract was not presented at the conference. Citation Format: Michael F. Moran, Thomas Kislinger, Lei Li, Vladimir Ignatchenko, Yuhong Wei, Christine To, Paul Taylor, Jiefei Tong, Nhu An Pham, Melania Pintilie, Lakshmi Muthuswamy, Frances A. Shepherd, Ming Sound Tsao. Integrated omic analysis of lung cancer reveals metabolism proteome signatures with prognostic impact. [abstract]. In: Proceedings of the AACR Special Conference on Computational and Systems Biology of Cancer; Feb 8-11 2015; San Francisco, CA. Philadelphia (PA): AACR; Cancer Res 2015;75(22 Suppl 2):Abstract nr B2-01.
<i>QuickStats</i>: Cancer Death Rates* for Children and Teens Aged 1–19 Years — United States, 1999, 2006, and 2014†
Journal: MMWR Morbidity and Mortality Weekly Report (2016)

Department of Health and Human Services/Centers for Disease Control and Prevention * Includes leukemia, brain cancer, and all other types of cancer (including "unspecified" types of cancer) determined using International Classification of Disease, Tenth Revision underlying cause of death codes: brain cancer (C71), leukemia (C91-C95), and all other sites (C00-C97).† Decline from 1999 to 2014 for leukemia and cancer of all other types was statistically significant (p<0.05).
PAUPER INSANE IN POOR-HOUSES.
Journal: JAMA (1890)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 039: A Comparison of Novel and Traditional Risk Factors for Cardiovascular Disease Across the Spectrum of Older Age: The Cardiovascular Health Study
Authors: Michelle C Odden, Michael Shlipak, Heather Whitson, Ronit Katz, Patricia Kearney, Christopher deFilippi, Shani Shastri, Mark Sarnak, David Siscovick, Mary Cushman, Bruce Psaty, Anne Newman
Journal: Circulation (2013)

Introduction: There is evidence that some traditional cardiovascular risk factors have weaker associations with outcomes in elderly adults; whereas, some novel risk factors appear important in old age. Whether the risk factors for cardiovascular disease differ in the oldest old compared with younger elders is uncertain. Hypothesis: The associations of traditional risk factors - systolic blood pressure, LDL-cholesterol, HDL-cholesterol, obesity, and diabetes - will be attenuated with age, whereas the associations of novel risk factors - kidney disease, inflammation, and cardiac stiffness - will be robust across older age. Methods: Participants in the Cardiovascular Health Study ≥65 years (n=4,853), were stratified into three age cohorts: 65-74, 75-84, 85+ years based on the age at the time of risk factor measure (baseline, 3, 7, or 16 years of follow-up). Proportional hazards models were used to assess the associations of the risk factors assessed at the most recent visit and a composite outcome of incident stroke, myocardial infarction, and cardiovascular death over 5 years. Results: There were 1,481 events. In adults 65-84 years, systolic blood pressure, HDL-cholesterol, diabetes, kidney disease, inflammation, and cardiac stiffness were associated with the composite outcome, after adjustment for demographic factors. In adults 85+ years, only the novel risk factors were associated with the outcome in demographic-adjusted analyses (Figure). In fully adjusted models, only inflammation was associated with the outcome across the age spectrum. HDL-cholesterol was independently associated with the outcome in adults &lt;75 years; systolic blood pressure, diabetes, cardiac stiffness, and kidney disease were associated with the outcome in adults &lt;85 years. Conclusions: The associations of traditional risk factors with cardiovascular outcomes appear attenuated in adults ≥85 years; this could impact optimal prevention strategies in the oldest old. Inflammation is a robust risk factor across the spectrum of old age.
Le traitement des varices par les injections locales sclérosantes.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Antioxidants, pro-oxidants, and their effects
Authors: V. Herbert
Journal: JAMA (1994)

<h3>To the Editor.</h3> —The May 11 issue of<i>JAMA</i><sup>1</sup>contains a two-page advertisement representing that the "antioxidant" vitamins are pure antioxidants and, therefore, helpful against coronary artery disease. In fact, they are redox agents, antioxidant in some circumstances, pro-oxidant in others. When present in physiological (recommended daily allowance [RDA]) amounts and when part of the balanced biochemistry of the more than 150 redox and nonredox chemicals in each fruit or vegetable, they tend to be antioxidant. When present in the pharmacologic (above-RDA) amounts found in supplements, they are unbalanced biochemistry, tend to be pro-oxidant, and also have many chemical actions unrelated to vitamin or redox activity. We reviewed these facts in 1994 in detail<sup>2</sup>and succinctly,<sup>3</sup>and we cited studies reporting harms from above-RDA amounts of "antioxidant" vitamins, including promotion of heart disease, cancer, and liver and kidney disease. The nonvitamin prohemorrhagic effect of pharmacologic (above-RDA) supplements
Rheumatology
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal