tbuckley/cabot-search huggingface dataset:
Correction: CD93 is expressed on chronic myeloid leukemia stem cells and identifies a quiescent population which persists after tyrosine kinase inhibitor therapy
Authors: Ross Kinstrie, Gillian A. Horne, Heather Morrison, David Irvine, Chinmay Munje, Eduardo Gómez Castañeda, Hothri A. Moka, Karen Dunn, Jennifer E. Cassels, Narissa Parry, Cassie J. Clarke, Mary T. Scott, Richard E. Clark, Tessa L. Holyoake, Helen Wheadon, Mhairi Copland
Journal: Leukemia (2020)

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Involvement of platelet-activating factor in cytokine production and neutrophil activation after hepatic ischemia-reperfusion
Authors: A Serizawa
Journal: Hepatology (1996)

Although platelet-activating factor (PAF) is implicated as an important mediator in the pathogenesis of hepatic ischemia-reperfusion (IR) injury, the precise mechanism of its action has not been studied. We examined the hypothesis that PAF may influence neutrophils by promoting the production of tumor necrosis factor α (TNF-α) and cytokine-induced neutrophil chemoattractant (CINC), a member of the interleukin-8 (IL-8) family, and may be associated with liver and lung injury during the early phase of reperfusion after total hepatic ischemia. Rats pretreated with a specific PAF receptor antagonist exhibited suppression of the increase in plasma TNF-α and CINC levels, as well as the priming of peripheral neutrophils for superoxide production after reperfusion when compared with animals pretreated with physiological saline. These effects resulted in a reduction of plasma liver enzymes and of hepatic and pulmonary neutrophil sequestration, as well as an increased survival rate. There was a strong correlation between the time course of CINC release and hepatic or pulmonary neutrophil sequestration. We concluded that PAF activates neutrophils, either directly or by promoting the production of TNF-α and CINC, and is involved in hepatic IR injury.
Epidemiologic Study on Yusho, a Poisoning Caused by Ingestion of Rice Oil Contaminated with a Commercial Brand of Polychlorinated Biphenyls
Authors: Masanori Kuratsune, Takesumi Yoshimura, Junichi Matsuzaka, Atsuko Yamaguchi
Journal: Environmental Health Perspectives (1972)

In October, 1968, an epidemic of a peculiar skin disease similar to chloracne was reported in Fukuoka-Ken (Fukuoka prefecture), Japan.The epidemic was later proved to have spread not only over Fukuoka-Ken but also over 20 other prefectures in the western part of Japan (Fig. 1).It produced 1,057 patients according to the latest tabulation (August, 1971) by the Ministry of Welfare.Soon after the epidemic was announced, a study group was organized by the staff of the faculties of medicine, pharmaceutical sciences, agriculture, and engineering of the Kyushu University and by the staff of the local health departments, to clarify the cause of the epidemic and to effectuate its control (1).We participated in the study group and conducted, as members of its epidemiologic study subgroup, an extensive epidemiologic investigation following the basic methodology of epidemiology (2).Fortunately, the cause of the epidemic was soon demonstrated to be the ingestion of a brand of rice oil contami- nated with a commercial brand of polychlorinated biphenyls, and the disease was called "Yusho", namely oil disease.Although our observations and experiences are confined to the Yusho patients seen in Fukuoka- Ken, we believe that reporting of them will help many people in the world who are deeply con-
Washerwoman
Authors: M. Therese Southgate
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Proceedings of the Royal Society of Medicine Medical Section 22 October 1907 Dr Gee, President of the Section, in the Chair
Journal: Journal of the Royal Society of Medicine (2007)

In 1907, the Royal Society of Medicine was formed, and a new journal was created—the Proceedings of the Royal Society of Medicine. At the first meeting of the Section of Medicine of the new Society, Dr Gee, President of the Section, gave a speech on the fragmentation of medicine into specialties. Here, the Journal of the Royal Society of Medicine is proud to reprint the Proceedings’ report on that speech.
The elderly: newest victims of familial abuse
Journal: JAMA (1980)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medical News
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ornament and symbolism in early medical books
Authors: F. H. Nesmith
Journal: JAMA (1970)

A century before the discovery of printing with movable type the illuminated manuscripts of Europe reached a peak of beauty. To some critics, the rich coloring, and design and craftsmanship throughout, have not been exceeded since. It was logical that the printers of 1450 would turn to these hand-written and hand-decorated books for their models, and attempt to reproduce their main features by new mechanical means. The first interchangeable letters were accordingly cut and cast in metal to resemble script. In general, the printed text began with a title high on the second leaf, each chapter began at the top of a new page, and the whole ended with a colophon or short paragraph which included the date and the printer's name. The spaces which remained at chapter ends were left empty. In manuscripts, the illuminator added a picture and ornament to a scribe's first page which were far more
Immunoglobulin heavy chain expression shapes the B cell receptor repertoire in human B cell development
Authors: Eric Meffre, Michèle Milili, Carla Blanco-Betancourt, Henedina Antunes, Michel C. Nussenzweig, Claudine Schiff
Journal: Journal of Clinical Investigation (2001)

Developing B cells must pass a series of checkpoints that are regulated by membrane-bound Igμ through the Igα-Igβ signal transducers. To determine how Igμ expression affects B cell development and Ab selection in humans we analyzed Ig gene rearrangements in pro-B cells from two patients who are unable to produce Igμ proteins. We find that Igμ expression does not affect VH, D, or JH segment usage and is not required for human Igκ and Igλ recombination or expression. However, the heavy and light chains found in pro-B cells differed from those in peripheral B cells in that they showed unusually long CDR3s. In addition, the Igκ repertoire in Igμ-deficient pro-B cells was skewed to downstream Jκs and upstream Vκs, consistent with persistent secondary V(D)J rearrangements. Thus, Igμ expression is not required for secondary V(D)J recombination in pro-B cells. However, B cell receptor expression shapes the Ab repertoire in humans and is essential for selection against Ab’s with long CDR3s.
Alcohol-related liver cirrhosis patients have higher-disease severity, one-year morbidity and mortality after index hospitalisation-followup of a cohort of 5,138 patients
Authors: Priyanka Jain, S Muralikrishna Shasthry, Ashok Choudhury, Guresh Kumar, Ankit Bhardwaj, Vinod Arora, Vijayraghavan Rajan, Ankur Jindal, Rakhi Maiwall, Manoj Kumar, Vikram Bhatia, Shiv Kumar Sarin
Journal: Journal of Hepatology (2020)
Climate-controlled disease?
Journal: Environmental Health Perspectives (1999)

Forumpeople may not modify their behavior to accommodate it.Also, homes in the Northeast, particularly in poorer areas that may lack air-conditioning, are red brick row houses with windows on only two sides and tar roofs, all of which trap heat.In contrast, in the South poorer people often live in frame houses with light col- ored roofs and windows on four sides, which helps mitigate the heat.The total number of "excess" deaths (above what would normally occur) in a given summer in Philadelphia was calculated by Kalkstein to be 129, versus 0 for Miami [EHP 105(1)84-93].Kalkstein says that each city has a particular heat threshold above which the number of deaths begin to rise.A key benefit of the UD system is that it is customized to reflect a given city's response to heat waves.
Probing to bone in infected pedal ulcers. A clinical sign of underlying osteomyelitis in diabetic patients
Authors: M. L. Grayson
Journal: JAMA (1995)

<h3>Objective.</h3> —To assess a bedside technique for diagnosing osteomyelitis. <h3>Design.</h3> —We prospectively assessed infected pedal ulcers for detectable bone by probing with a sterile, blunt, stainless steel probe. We then examined the relationship between detection of bone and the presence or absence of osteomyelitis that was defined histopathologically and/or clinically. <h3>Setting.</h3> —A tertiary care center. <h3>Patients.</h3> —Seventy-five hospitalized diabetic patients with a total of 76 infected foot ulcers were studied. <h3>Results.</h3> —Osteomyelitis was diagnosed in 50 instances (66%) and was excluded in 26 instances. Bone was detected by probing in 33 of 50 ulcers with contiguous osteomyelitis; in contrast, bone was probed in only four of 26 ulcers without contiguous osteomyelitis (<i>P</i>&lt;.001). Bone detected on probing was visible in only three instances. Palpating bone on probing the pedal ulcer had a sensitivity of 66% for osteomyelitis, a specificity of 85%, a positive predictive value of 89%, and a negative predictive value of 56%. <h3>Conclusions.</h3> —Palpation of bone in the depths of infected pedal ulcers in patients with diabetes is strongly correlated with the presence of underlying osteomyelitis. If bone is palpated on probing, specialized roentgenographic and radionuclide tests to diagnose osteomyelitis are unnecessary. Probing for bone should be included in the initial assessment of all diabetic patients with infected pedal ulcers. (<i>JAMA</i>. 1995;273:721-723)
A phase IB, open label, safety and pharmacokinetic (PK) study of escalating doses of PTK787/ZK 222584 in combination with paclitaxel and carboplatin in patients (PTs) with stage IIC to IV epithelial ovarian cancer
Authors: W. Schroder, E. Witteveen, S. Abadie, M. Campone, P. Viens, T. Jalava, E. Masson, A. Chlistalla, A. Du Bois
Journal: Journal of Clinical Oncology (2005)

5042 Background: PTK787/ZK 222584 (PTK/ZK) is a novel, oral, small molecule, anti-angiogenisis compound that blocks tyrosine kinase signaling from all known vascular endothelial growth factor VEGF receptors (VEGF-Rs). Based on its biologic activity, PTK/ZK is under investigation for the treatment of Pts with solid tumors known to overexpress VEGF-R such as ovarian cancer. Methods: An open label, multicenter, phase IB dose escalation study was initiated to evaluate PTK/ZK in combination with chemotherapy as first line therapy in Pts with stage IIC to IV epithelial ovarian cancer. Treatment consisted of paclitaxel administered as a 3-hour infusion on day 1 of each 21-day cycle at a dose of 175 mg/m2 following appropriate premedication. Carboplatin was given immediately after paclitaxel as a 30-min IV infusion to a target area under the plasma concentration time curve (AUC) of 5 mg min/mL. PTK/ZK was given once daily from day 3 to day 21 of each chemotherapy cycle. PTK/ZK was withheld on the day of chemotherapy and the day following chemotherapy. Cohorts of 3 to 6 Pts received doses of PTK/ZK at 250 mg, 500 mg, 750 mg, 1000 mg or 1250 mg/day. Goals of this study were to determine the maximal tolerated dose (MTD) of PTK/ZK, dose limiting toxicity (DLT) of PTK/ZK and to characterize the PK of PTK/ZK with carboplatin and paclitaxel. Results: 18 Pts were evaluated to date, with 16 evaluable for DLT, (n=3, 4, 3, 3, 3 from the 250 mg, 500 mg, 750 mg, 1000 mg and 1250 mg cohorts respectively). 14 patients were evaluable for PK (n=3, 3, 3, 2, 3 from the 250 mg, 500 mg, 750 mg, 1000 mg and 1250 mg cohorts respectively.) No DLTs or PTK related serious adverse events (AEs) were reported. None of the Pts discontinued the study due to AEs. Grade 1 and 2 hypertension was the most frequently reported AE. PTK/ZK plasma level was not affected by paclitaxel or carboplatin. PTK/ZK also has no impact on the systemic exposure of carboplatin. The effect of PTK/ZK at the 1250 mg dose on paclitaxel and its metabolites require further study. Conclusion: Combination of PTK/ZK with paclitaxel and carboplatin is feasible and shows acceptable safety profile. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Novartis, Schering AG
GOVERNMENT SERVICES
Journal: JAMA (1953)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
American Journal Veterinary Research, Chicago
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Localization and resection of insulinomas and gastrinomas
Authors: D. L. Fraker
Journal: JAMA (1988)

<h3>SELECTED CASES</h3><h3>Case 1</h3> A 45-YEAR-OLD woman with a threeyear history of epigastric pain was treated initially with cimetidine and then with ranitidine hydrochloride and antacids, with only mild relief. Her fasting serum gastrin level was elevated at 496 ng/L (496 pg/mL) (normal, &lt;100 ng/L [&lt;100 pg/mL]). Her basal acid output was 32 mEq/h (normal, &lt;15 mEq/h). The results of her secretin stimulation test were abnormal, with a rise in the serum gastrin level from 239 ng/L (239 pg/mL) at baseline to 825 ng/L (825 pg/mL) (abnormal increment, &gt;200 ng/L [&gt;200 pg/mL]). Ultrasound, computed tomographic (CT) scan, and selective angiogram all failed to demonstrate a gastrinoma. Selective venous sampling was performed and a marked step-up in gastrin levels was found in the superior pancreaticoduodenal vein (Fig 1). The patient underwent an exploratory laparotomy, and intraoperative ultrasound demonstrated a lesion in the posterior head of the pancreas (Fig 2). After enucleation,
Acetaminophen overdose in the third trimester of pregnancy
Authors: A. J. Byer
Journal: JAMA (1982)

Acetaminophen is frequently used in pregnancy but can be lethal when taken in sufficient quantities. How much of an overdose crosses the placenta and exactly how the in vivo fetus deals with this insult are unknown. However, it does appear that both the mother and fetus can have a good outcome in the third trimester, if treatment is begun early and response is rapid. (<i>JAMA</i>1982;247:3114-3115)
Abstract 3711: Increased Expression of Plasma Granzyme B in the Patients with Coronary Artery Disease Complicated with Chronic Kidney Disease
Authors: Tomokazu Ikemoto, Yukihiro Hojo, Hideyuki Kondo, Nozomu Takahashi, Masahiro Hirose, Ken-ichi Ohya, Takaaki Katsuki, Kazuyuki Shimada
Journal: Circulation (2008)

Background: Recent clinical studies have revealed that chronic kidney disease (CKD) is a significant independent risk factor for major cardiovascular events. However, the mechanisms in which CKD increases the incidence of cardiovascular diseases are still not fully understood. Hypothesis: Granzyme B is a member of serine protease family released from cytotoxic T lymphocytes and plays an important role in cellular apoptosis via an activation of caspases. We hypothesized that granzyme B is involved in formation of coronary artery lesions in patients with CKD. Objectives: To elucidate the role of granzyme B in coronary artery disease (CAD) in patients complicated with CKD. Subjects and methods: We employed 141 patients (116 men and 25 women, mean age: 64.2±9.6 years old ). Diagnosis of CAD was confirmed by selective coronary angiography. CKD was defined as sustained decrease in estimated glomerular filtration rate less than 60 mL/min/1.73m 2 over 3 months. We assigned patients into three groups; CAD without CKD (CAD group, n=46), CKD without CAD (CKD group, n=17) and CAD with CKD (CAD/CKD group, n=78). Patients with acute coronary syndrome, immunological disorder, malignancy and acute inflammatory diseases were excluded from the study. Results: Analysis of variance showed that plasma levels of high-sensitive CRP (hsCRP) and granzyme B in CAD/CKD group were significantly higher than those in the other groups (hsCRP: CAD; 2420±763, CKD; 1802±584, CAD/CKD: 7419±2171 ng/mL, p&lt;0.05, granzyme B: CAD: 9.1±2.3, CKD: 42.2±2.4, CAD/CKD: 159±51.8 pg/mL, p&lt;0.01). A significant positive correlation was observed between plasma hsCRP and granzyme B levels (r=+0.30, p&lt;0.05). A significant negative correlation was observed between eGFR and granzyme B levels (r=−0.32, p&lt;0.01). Multiple regression analysis revealed that granzyme B and hs CRP levels were independent predicting variables for the number of stenosis in major coronary arteries (F=5.35, p=0.002, beta coefficients: granzyme B=+0.24, p=0.006, hsCRP=+0.18, p=0.03). Conclusions: These results indicate that granzyme B might be a critical enzyme for formation of coronary atherosclerosis by inducing apoptosis of vascular tissues in patients with CKD.
Incorrect Figure
Authors: John Stone
Journal: JAMA (1999)

The only prospective study of this question that I am aware of-an examination of 14 consecutive French women with histologically confirmed AFLP4-did not find relevant mutations (in the gene for the a-subunit of LCHAD) among any of the patients. 4he small number of patients in this study (as well as the other studies) precludes firm conclusions about the putative role of LCHAD deficiency in complications of pregnancy.When the etiologies of HELLP and other severe complications of pregnancy are understood, disorders of lipoprotein metabolism may prove to contribute to a portion of cases.Similarly, screening of mothers with certain disorders (eg, AFLP) and their offspring may prove beneficial.However, the current understanding of this question leaves unclear which types of maternal complications should trigger screening for this defect.Until the true associations between LCHAD deficiency and pregnancy complications (and the magnitude of such associations) are defined more completely, calls for screening of all mothers with the HELLP syndrome may be premature.