tbuckley/cabot-search huggingface dataset:
Abstract P234: The Relationship Between Polyphenols and Body Composition within the Hispanic Community Health Study/Study of Latinos Nutrition and Activity Study
Authors: Nour Makarem, Yasmin Mossavar-Rahmani, Daniela Sotres-Alvarez, Simin Hua, William W Wong, Linda Van Horn, Martha L Daviglus, Adrian Franke, Jeannette M Beasley
Journal: Circulation (2017)

Background: Polyphenols have antioxidant properties that may protect against chronic disease.Epidemiological evidence regarding potential impact on body composition and obesity is limited, particularly among Hispanics/Latinos who are disproportionately prone to obesity. Hypothesis: Polyphenols are associated with lower percent body fat (%BF) and prevalence of obesity, with moderate intra-class correlations between repeated measures. Methods: Participants were 442 adults from SOLNAS aged 18-74y. Doubly labeled water, a recovery biomarker, estimated Total Energy Expenditure . Polyphenol excretion from 24-hour urine samples was assessed for enterolactone, enterodiol, resveratrol, daidzein, urolithin A, naringenin, hesperetin, and quercetin (nmol/liter). Measures were repeated in a subsample (N=90) to provide a reliability measure. Anthropometric measures were obtained by trained personnel, and %BF was measured by 18 O dilution. Diet was assessed using two 24-hour recalls. Linear regression models were used to evaluate the multivariable associations between body composition and polyphenols. Spearman correlations between BMI and %BF with polyphenols and intra-class correlation coefficients (ICCs) between repeated polyphenol measures were computed. Results: Resveratrol and %BF were weakly correlated (r=-0.11, p=0.02), but 69% of urinary resveratrol levels were below detectable limits. Hesperetin was associated with a 12% lower odds of obesity in models unadjusted for TEE (Table 1), while enterolactone was associated with 16% higher odds in fully-adjusted models. Repeated polyphenol measures were moderately correlated (ICCs:0.11-0.65). Urinary polyphenols and their main food sources were weakly correlated (r=0.10-0.17, p&lt;0.03). Conclusions: Hesperetin and quercetin were inversely while enterolactone was positively associated with obesity. Findings are indicative of an immigrant group in transition. Repeated measures of urinary polyphenols could help clarify impact on obesity.
Tuberculosis in Students: Report of Experiences
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Strategy of prevention: lessons from cardiovascular disease.
Journal: BMJ (1981)

1968 70 72 74 76 77 FIG 1-Age-adjusted death rates from coronary heart disease (ICD, 8th revision, 410-14) among men aged 35-74 in various countries.Australia and the United States at the start of the period they were high, but they have fallen by some 25%.In England and Wales they started a little short of the American and Australian rates and have shown little change.The Japanese owe their low rates not to their genes but to their way of life: when they move to America they rather quickly acquire American rates.The large recent declines in Australia and the United States must surely be due largely to a declining incidence of disease, since
Various Forms of Hysterical or Functional Paralysis.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Laser radiation for metastatic malignant melanoma
Authors: P. E. McGuff
Journal: JAMA (1966)

THIS REPORT is that of a 46-year-old white woman of Irish ancestry, whom I first saw in October 1964, whose left thigh revealed on its anterior and medial surfaces multiple malignant metastatic melanoma. These presented as approximately 200 verrucous, blackish-brown lesions, ranging in size from 2 mm to 2.2 cm. At the lower end of an inguinal scar, there was a firm, discrete, 4.0 × 3.3 × 3.1-cm subcutaneous mass. The clinical impression was multiple metastatic malignant melanoma, recurrent, with widespread involvement of the left thigh, inguinal area, and with a possible large inguinal melanotic mass. <h3>Report of a Case</h3> In April 1963, the patient had a wide excision elsewhere of a black mole from the left lateral aspect of the lower one third of the leg, with a pathological diagnosis of malignant melanoma. This was radically excised, and a skin graft was applied. A radical left-groin dissection was performed
Latent morbidity after abortion.
Journal: BMJ (1973)

A recent paper by M. Wynn and A. Wynn warns against long-term effects of abortion, designated "latent morbidity." Present practice of a short follow-up period is said to be inadequate. After several years the morbidity rate may be 30%. Increases in subsequent perinatal deaths, premature births, ectopic pregnancies, pelvic inflammation, menstrual disorders, and subsequent sterility are said to follow. A statistically significant increase in premature labors, more frequent postpartum hemorrhage, more spontaneous abortions, rhesus isoimmunization, and even congenital malformations are claimed to result. Since 1970, the number of illegitimate births in Britain are said to have only slightly decreased. Abortion is referred to as being used to replace a contraceptive method. The effect of human behavior is questioned. It may be argued that the case is overstated but the supporters of abortion need to reply.
The Cover
Authors: Marsha F. Goldsmith
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BACTERIOGENOUS URIC ACID
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Suicide risk is increased in stroke
Journal: BMJ (1998)

Early selegiline treatment in Parkinson's disease may not be advantageous A previous report from the UK Parkinson's Disease Research Group's randomised controlled trial noted that patients with early, mild Parkinson's disease treated with selegiline and levodopa (arm 2) had around 60% increased mortality compared with those given levodopa alone (arm 1).On p 1191 Ben-Shlomo et al examined whether this increased mortality was maintained and tested possible explanations such as orthostatic hypotension, more rapidly deteriorating disease, and adverse drug interactions with other drugs.The extended results show a persistent but smaller excess mortality with combined treatment.Patients who died in arm 2 were more likely to have had possible dementia before death.The results do not support the use of combined treatment in newly diagnosed disease.In more advanced disease its avoidance in patients with postural hypotension, frequent falls, confusion, and dementia may be advisable.
In-depth cDNA Library Sequencing Provides Quantitative Gene Expression Profiling in Cancer Biomarker Discovery
Authors: Wanling Yang, Dingge Ying, Yu-Lung Lau
Journal: Genomics Proteomics & Bioinformatics (2009)

Quantitative gene expression analysis plays an important role in identifying differentially expressed genes in various pathological states, gene expression regulation and co-regulation, shedding light on gene functions. Although microarray is widely used as a powerful tool in this regard, it is suboptimal quantitatively and unable to detect unknown gene variants. Here we demonstrated effective detection of differential expression and co-regulation of certain genes by expressed sequence tag analysis using a selected subset of cDNA libraries. We discussed the issues of sequencing depth and library preparation, and propose that increased sequencing depth and improved preparation procedures may allow detection of many expression features for less abundant gene variants. With the reduction of sequencing cost and the emerging of new generation sequencing technology, in-depth sequencing of cDNA pools or libraries may represent a better and powerful tool in gene expression profiling and cancer biomarker detection. We also propose using sequence-specific subtraction to remove hundreds of the most abundant housekeeping genes to increase sequencing depth without affecting relative expression ratio of other genes, as transcripts from as few as 300 most abundantly expressed genes constitute about 20% of the total transcriptome. In-depth sequencing also represents a unique advantage of detecting unknown forms of transcripts, such as alternative splicing variants, fusion genes, and regulatory RNAs, as well as detecting mutations and polymorphisms that may play important roles in disease pathogenesis.
The effect of a recent previous visit to a physician on outcome after childhood bacterial meningitis
Authors: M. J. Kallio
Journal: JAMA (1994)

<h3>Objective.</h3> —To assess the effect of a recent previous visit to a physician on the outcome of meningitis in children. <h3>Design.</h3> —Evaluation of data from children examined by a physician and sent home, either the previous day or 2 to 4 days before meningitis was diagnosed, and children whose meningitis was diagnosed at once. The patients were examined daily during hospitalization, neurologic examinations were repeated at 2 weeks and 3 and 6 months after discharge, and hearing was assessed 2 or more months after discharge. <h3>Setting.</h3> —Eighteen pediatric hospitals in Finland from 1984 through 1991. <h3>Population.</h3> —A total of 325 children aged 3 months to 15 years with bacterial meningitis. <h3>Main Outcome Measures.</h3> —Clinical and laboratory findings on admission, recovery during hospitalization, mortality, and neurologic abnormalities at 6 months of follow-up. <h3>Results.</h3> —In 74% of the patients, meningitis was diagnosed at once, 14% had visited a physician on the previous day, and 11% had seen a physician 2 to 4 days before diagnosis. The group seen 2 to 4 days earlier had a better level of consciousness, less frequent seizures, and more respiratory symptoms and otitis media than the other groups. The cerebrospinal fluid leukocyte count, white blood cell count, and erythrocyte sedimentation rate were highest and the cerebrospinal fluid glucose concentration was lowest in the children who had visited a physician 2 to 4 days earlier, although they also had lower cerebrospinal fluid protein and urine sodium and potassium levels. This group had the most rapid return to normal consciousness. There was no difference in the incidence of hearing impairment or neurologic sequelae. Even the mortality was virtually the same in the three groups: 4%, 4%, and 3% in the "same day," "previous day," and "2 to 4 days earlier" groups, respectively. <h3>Conclusions.</h3> —Children who had visited a physician the previous day or 2 to 4 days before meningitis was diagnosed did not exhibit an increased frequency of hearing impairment, other neurologic abnormalities, or overall adverse outcome compared with children whose meningitis was diagnosed at once. (<i>JAMA</i>. 1994;272:787-791)
Imvexxy <i>–</i> Another Estradiol Vaginal Insert for Dyspareunia
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medical Management of Primary Hypertension
Authors: Lot B. Page, James J. Sidd
Journal: New England Journal of Medicine (1972)

Evidence summarized in the first part of this review indicates that reducing elevated blood pressure by administration of pharmacologic agents is effective in reducing the morbidity and mortality of cardiovascular disease associated with hypertension. Although still incomplete, the evidence also suggests that the objective of treatment should be reduction of blood pressure to as low a value as can be achieved without producing symptomatic hypotension. It is probable that the earlier treatment is instituted, and the more consistently blood pressure is maintained at a reduced level, the greater will be the effect in reducing the risk of vascular disease. There . . .
Passports and privilege: access denied
Authors: None The Lancet Global Health
Journal: The Lancet Global Health (2019)

Last October, Liverpool, UK, hosted the Fifth Global Symposium on Health Systems Research. At least 10 overseas delegates planning to attend the biennial gathering of researchers, practitioners, and policy makers dedicated to strengthening health systems around the world were unable to do so because they were denied visas for entry to the UK, despite some having been awarded full scholarships to support the cost of the trip. The following month, 16 speakers and delegates from African countries and three from Asian countries could not be present at the second Women Leaders in Global Health conference at the London School of Hygiene & Tropical Medicine due to visa refusals, prompting the Director of the School to write to the UK Home Secretary in protest.
THE PRODUCTION OF ANTITOXIN BY AUTOLYSIS.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Gastrointestinal disease: Pathophysiology/diagnosis/management 5th Edition. Edited by M. H. Sleisenger and J. S. Fordtran and Associate Editors B. F. Scharschmidt and M. Feldman, 2445 pp. Philadelphia: W.B. Saunders, 1993, $185
Authors: R Koff
Journal: Hepatology (1994)
ABC trial (A011502): Randomized phase III double blinded placebo controlled trial of aspirin as adjuvant therapy for breast cancer.
Authors: Wendy Y. Chen, Eric P. Winer, William Thomas Barry, Ann H. Partridge, Lisa A. Carey, Margaret Carvan, Carol Matyka, Kala Visvanathan, Banu Symington, Michelle D. Holmes
Journal: Journal of Clinical Oncology (2018)

TPS597 Background: In-vitro and in-vivo evidence suggest that aspirin may have an anti-tumor effect. Epidemiologic studies have reported improved breast cancer survival among regular aspirin users compared to non-users. Pooled data from randomized trials of aspirin for cardiovascular disease have also reported a decreased risk of metastatic cancer with aspirin use. However, the exact benefits and risks for breast cancer survivors need to be confirmed in a randomized trial. Even if the clinical effect were modest, the global impact would be substantial since aspirin is inexpensive and widely available. Methods: Primary objective is to compare the effect of 300 mg daily aspirin vs placebo upon invasive disease-free survival (iDFS) in high risk HER2 negative breast cancer patients. Secondary objectives include effects on overall survival, cardiovascular disease, toxicity, and adherence. A biospecimen repository will be created for correlative analyses including tumor collection at baseline and blood and urine samples and questionnaires assessing lifestyle factors associated with inflammation (pain, sleep, stress, depression) at baseline and 2 years. Study design: Subjects will be randomized 1:1 to aspirin 300 mg vs placebo daily for 5 years in a double-blind fashion. Stratification factors include hormone receptor (HR) status (positive vs negative), body mass index ( < or ≥ 30 kg/m2), and stage. Subjects will be followed every 6 months while on study drug, then annually for 10 years. Accrual goal is 2936 patients to reach 381 iDFS events with 80% power to detect HR 0.75 assuming 5-year iDFS on placebo of 77%. Eligibility: Patients aged 18-70 diagnosed with a primary invasive HER2 negative breast cancer in the past year. If HR positive, tumors need to be node positive. If HR negative, tumor can be node positive or node negative with tumor size > 2 cm. Patients who currently use any anticoagulant or those with a prior history of GI bleeding, atrial fibrillation, or myocardial infarction will be excluded. Regular aspirin users need to stop 30 days prior to enrollment. Study is actively enrolling. Updated accrual numbers will be given at the time of presentation. Clinical trial information: NCT02927249.
Use of Folic Acid–Containing Supplements Among Women of Childbearing Age—United States, 1997
Journal: JAMA (1998)

Each year in the United States, approximately 4000 pregnancies result in spina bifida or anencephaly. Babies born with spina bifida usually survive, often with serious disability, but anencephaly is invariably fatal. The B vitamin folic acid can reduce the occurrence of spina bifida and anencephaly by at least 50% when taken daily before conception and during early pregnancy. In 1992, the Public Health Service (PHS) recommended that all women of childbearing age who are capable of becoming pregnant consume 400 microg of folic acid daily. This report summarizes findings from a survey conducted during January and February 1997 and indicates that only one third of women of childbearing age consume a supplement containing the recommended amount of folic acid daily.