tbuckley/cabot-search huggingface dataset:
Die Krankheiten der endokrinen Drüsen.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An open community trial of live rubella vaccines. Study of vaccine virus transmissibility and antigenic efficacy of three HPV-77 derivatives
Authors: J. A. Veronelli
Journal: JAMA (1970)

Six hundred and thirty six families including 1,686 children participated in a trial of HPV-77-derived live attenuated rubella virus vaccines. Transmission of vaccine virus was not observed among 347 susceptible household contacts of vaccinated children. The observed absence of transmission of vaccine virus indicates that vaccination of children is unlikely to represent a hazard to their pregnant mother. Antibody levels induced by vaccination were lower than those induced by natural disease. Statistically significant differences in antigenic efficacy were observed among the three vaccines tested. The paucity of data so far available on long-term protection afforded by vaccination and on susceptibility to reinfection among vaccines and its significance make it advisable to continue the surveillance of children that participated in controlled trials.
Hypersensitivity Pneumonitis from Ordinary Residential Exposures
Authors: Michael J. Apostolakos, Harold Rossmoore, William S. Beckett
Journal: Environmental Health Perspectives (2001)

A previously healthy woman developed hypersensitivity pneumonitis of such severity that she required chronic systemic corticosteroid therapy for symptom control. Detailed investigation of her workplace and home environments revealed fungi in her typical suburban home, to which she had specific serum precipitating antibodies. Efforts to remove mold from the home were unsuccessful in relieving symptoms, and moving to another residence was the only intervention that allowed her to be withdrawn from corticosteroid therapy. Hypersensitivity pneumonitis is commonly associated with occupational or avocational exposures, such as moldy hay in farmers or bird antigen in bird breeders. We propose that hypersensitivity pneumonitis may occur in North America, as it does in Japan, from domestic exposures alone.
Increased tissue factor pathway inhibitor in patients with acute myocardial infarction
Authors: Yuko Kamikura, Hideo Wada, Atsushi Yamada, Minori Shimura, Katsuyo Hiyoyama, Hiroshi Shiku, Motoaki Tanigawa, Hideo Nishikawa, Norikazu Yamada, Naoki Isaka, Takeshi Nakano, Kousuke Kumeda, Hisao Kato
Journal: American Journal of Hematology (1997)

We examined hemostatic abnormalities in 23 patients with acute myocardial infarction (AMI), 10 with pulmonary embolism (PE), and 10 with deep vein thrombosis (DVT). At the onset of AMI, plasma levels of tissue-type plasminogen activator (t-PA), PA inhibitor-I (PAI-I), fibrin-D-dimer, thrombin-antithrombin complex (TAT), and plasmin-plasmin inhibitor complex (PPIC) were significantly increased. Both the plasma total TFPI and free-TFPI levels in the AMI patients were significantly higher than those in the healthy volunteers, PE patients, and DVT patients. There was no significant difference in total TFPI or free-TFPI among patients with PE, those with DVT, and healthy volunteers. One hour after percutaneous transluminal coronary angioplasty (PTCA) in the AMI group, the total TFPI level was further increased, and it was significantly reduced 24 hr after PTCA, to a level similar to that in healthy volunteers. Free-TFPI showed a pattern similar to that of total TFPI. The ratio of free-TFPI/total TFPI was highest 1 hr after PTCA. Increased TFPI in AMI patients might be released from ischemic tissues. Am. J. Hematol. 55:183–187, 1997. © 1997 Wiley-Liss, Inc.
Infant Mortality—United States, 1988
Journal: JAMA (1991)

In 1989, the infant mortality rate for the United States--9.8 infant deaths per 1000 live births--was the lowest final rate ever recorded; the previous low (10.0 per 1000 live births) was recorded in 1988. However, the infant mortality rate in the United States remains higher than that in many other developed countries. This report summarizes 1989 infant mortality data based on information from death certificates compiled through the Vital Statistics System of CDC's National Center for Health Statistics (NCHS) (1) and compares findings with those for 1988.
A case-control study of baldness in relation to myocardial infarction in men
Authors: S. M. Lesko
Journal: JAMA (1993)

<h3>Objective.</h3> —To examine the relationship between male pattern baldness and the risk of myocardial infarction in men under the age of 55 years. <h3>Design and Participants.</h3> —A hospital-based, case-control study was conducted in eastern Massachusetts and Rhode Island. Cases were men admitted to a hospital for a first nonfatal myocardial infarction (n=665); controls were men admitted to the same hospitals with noncardiac diagnoses (n=772). Extent of baldness was assessed using the 12-point modified Hamilton Baldness Scale; other information was obtained by personal interview. Among the controls, the prevalence of any baldness was 34%, while the prevalence of baldness involving the vertex scalp was 23%. <h3>Results.</h3> —After allowing for age, the relative risk estimate for frontal baldness compared with no hair loss was 0.9 (95% confidence interval, 0.6 to 1.3), for baldness involving the vertex scalp it was 1.4 (95% confidence interval, 1.2 to 1.9). Risk of myocardial infarction increased as the degree of vertex baldness increased (<i>P</i>&lt;.01); for severe vertex baldness the relative risk was 3.4 (95% confidence interval, 1.7 to 7.0). The relationship between vertex baldness and myocardial infarction was consistent within strata defined by age and other risk factors for coronary artery disease. <h3>Conclusion.</h3> —These data support the hypothesis that male pattern baldness involving the vertex scalp is associated with coronary artery disease in men under the age of 55 years. (<i>JAMA</i>. 1993;269:998-1003)
Lectures on the Experimental Investigation of the Action of Medicines
Authors: T. L. Brunton
Journal: BMJ (1871)

Comgparison of the Effects of Drugms on different Animals in different Doses.-AMode of determining the Exact Cause of Syito;noms.-Mode of raising Blood-pressure.-Modes of countintg the Beats of thle Heart.-Causes of Quickened Puilse.-DirectStimnulatmon of the Sympathletic.-Stimulation of Cardliac Ganzglia.-Paw alysis of the Vagus-roots and Fibres, and of its ends in thte Heart.-Causes of Slow Pulse.-Irritation of Vagus-roots.-Mode of supplying tze HIead and Body wit/i different kinds of Blood.-Indirect Irritation of V/agus-roots thzrought the Blood-pressutre: mode of lowering and rais- iZg it.-ReftexlIrritationt of Vagus-roots.-Indirect Irritationt through the Respiration.-Irritation of Vagus-fibres.-IncreasedConducting Power of Fibres.-Stimulationt of Vagus-ends.-Paralysis of thte Sym- tat hetic.-Paralysis of the Cardiac Ganglia.-Part ofthte Ganglionic Apparatus Aftected.-Nervous Systemt in the Heart.-MotorGanglia.-Stimulating Ganglia.-Inhibitory Ganglia.-ConnectingApparatus.-Action of Drtugs on the Inhibitory Apparatus-Nicotia, Muscaria.-Antagonism of Atropia and Physostigma: bearizgofthis on Thera- peutics.-Paralysis of Co-ordinating Apparatuis.-Paralysis of the Muscular Fibres of the Heart.-Blood-pressure:mode of determining whetizer chaszges in it are due to alterations in
The eVALuate study: two parallel randomised trials, one comparing laparoscopic with abdominal hysterectomy, the other comparing laparoscopic with vaginal hysterectomy
Journal: BMJ (2004)

Remedial action is necessary if this lack of professional capacity is common.If it is the problem could be addressed by brief training courses on arsenic and public health for all medical practitioners in Bangladesh.Millions of Bangladeshis may be at risk of life threatening complications of chronic arsenic ingestion.
AMA grams
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tapia Syndrome
Authors: Joseph G. Chusid
Journal: JAMA (1974)

<h3>To the Editor.—</h3> Some clarification of Tapia syndrome seems to be in order, judging by questions raised by my residents and associates in neurology after the recent letter of Mayer and Opran (227:326, 1974) who referred to my book<sup>1</sup>in their discussion. Tapia syndrome was described in 1906 by Antonio Garcia Tapia.<sup>2</sup>Synonyms used for it have included nucleus ambiguous-hypoglossal syndrome, vagohypoglossal syndrome, and palatopharyngolaryngeal paralysis.<sup>3</sup> This syndrome, characterized by ipsilateral paralysis of the larynx and tongue, has usually been ascribed to a lesion of the tegmentum of the lower medulla involving the vagus (X) and hypoglossal nerve (XII) nuclei. However, De Jong<sup>4</sup>among others has commented that this clinical syndrome could also result from an extramedullary lesion with involvement of the vagus (X) and hypoglossal (XII) nerves high in the neck. Chusid<sup>1</sup>stated that Tapia syndrome might be produced by a lesion affecting the
John Morgan (1735-1789) founder of American medical education
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medical education programs sponsored by government agencies
Journal: JAMA (1981)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Home based versus centre based cardiac rehabilitation: Cochrane systematic review and meta-analysis
Journal: BMJ (2010)

Objective To compare the effect of home based and supervised centre based cardiac rehabilitation on mortality and morbidity, health related quality of life, and modifiable cardiac risk factors in patients with coronary heart disease.Design Systematic review.Data sources Cochrane Central Register of Controlled Trials (CENTRAL) in the Cochrane Library, Medline, Embase, CINAHL, and PsycINFO, without language restriction, searched from 2001 to January 2008.Review methods Reference lists checked and advice sought from authors.Included randomised controlled trials that compared centre based cardiac rehabilitation with home based programmes in adults with acute myocardial infarction, angina, or heart failure or who had undergone coronary revascularisation.Two reviewers independently assessed the eligibility of the identified trials and extracted data independently.Authors were contacted when possible to obtain missing information.Results 12 studies (1938 participants) were included.Most studies recruited patients with a low risk of further events after myocardial infarction or revascularisation.No difference was seen between home based and centre based cardiac rehabilitation in terms of mortality (relative risk 1.31, 95% confidence interval 0.65 to 2.66), cardiac events, exercise capacity (standardised mean difference -0.11, -0.35 to 0.13), modifiable risk factors (weighted mean difference systolic blood pressure (0.58 mm Hg, -3.29 mm Hg to 4.44 mm Hg), total cholesterol (-0.13 mmol/l, -0.31 mmol/l to 0.05 mmol/l), low density lipoprotein cholesterol (-0.15 mmol/l, -0.31 mmol/l to 0.01 mmol/l), or relative risk for proportion of smokers at follow-up (0.98, 0.73 to 1.31)), or health related quality of life, with the exception of high density lipoprotein cholesterol (-0.06, -0.11 to -0.02) mmol/l).In the home based participants, there was evidence of superior adherence.No consistent difference was seen in the healthcare costs of the two forms of cardiac rehabilitation.Conclusions Home and centre based forms of cardiac rehabilitation seem to be equally effective in improving clinical and health related quality of life outcomes in patients with a low risk of further events after myocardial infarction or revascularisation.This finding, together with the absence of evidence of differences in patients' adherence and healthcare costs between the two approaches, supports the further provision of evidence based, home based cardiac rehabilitation programmes such as the "Heart Manual."The choice of participating in a more traditional supervised centre based or evidence based home based programme should reflect the preference of the individual patient.
Purified duck embryo rabies vaccine. An accelerated schedule for preexposure immunization against rabies
Authors: K. E. Nelson
Journal: JAMA (1977)

Seroconversion and adverse reaction rates were studied in 92 persons given four or five doses in a two-week period of duck embryo rabies vaccine (DEV) or duck embryo rabies vaccine purified by ultracentrifugation (P-DEV). Mouse-neutralizing antibodies developed in 78 of 92 (84.8%) persons in these accelerated schedules. There were no significant differences in the frequency of antibody conversion or in geometric mean titers of antibody between persons given either vaccine. However, local and systemic adverse reactions were substantially less common with P-DEV. These data suggest that four or five doses of DEV or P-DEV given in a two-week course can be used for preexposure prophylaxis in situations where the more drawn-out regimens would result in continuation of a high-risk of rabies exposure. The antibody response of persons given this more accelerated regimen must be determined. (<i>JAMA</i>238:218-220, 1977)
Reaction Products of Ozone: A Review
Authors: William H. Glaze
Journal: Environmental Health Perspectives (1986)

The reaction products of ozone that form during the oxidation of compounds found in aqueous media are reviewed. Reaction products of ozone are well documented only for a limited number of substrates, and mechanistic information is quite rare. Decomposition of ozone during its reactions, sometimes induced by matrix impurities or by the by-products of the reactions, will generate highly reactive hydroxyl radicals. Thus, even reactions occurring at pH less than 7 may have radical character. More complete destruction of organic substrates may be enhanced by using catalysts, such as ultraviolet radiation or hydrogen peroxide, to accelerate radical formation. However, complete mineralization is generally not practical economically, so partially oxidized by-products can be expected under typical treatment conditions. Ozone by-products tend to be oxygenated compounds that are usually, but not always, more biodegradable and less toxic than xenobiotic precursors. Of particular interest are hydroperoxide by-products, which may have escaped detection because of their lability, and unsaturated aldehydes. Inorganic by-products tend to be in high oxidation states, which in some cases (e.g., some metallic elements) may lead to enhanced removal by flocculation and sedimentation. In other cases oxidation may lead to formation of reactive species such as hypobromous acid from bromide ion or permanganate from manganous ion. In general, more research is required before a valid assessment of the risks of ozone by-products can be made.
A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model
Authors: Rolf Postina, Anja Schroeder, Ilse Dewachter, Juergen Bohl, Ulrich Schmitt, Elzbieta Kojro, Claudia Prinzen, Kristina Endres, Christoph Hiemke, Manfred Blessing, Pascaline Flamez, Antoine Dequenne, Emile Godaux, Fred van Leuven, Falk Fahrenholz
Journal: Journal of Clinical Investigation (2004)

Alzheimer disease (AD) is characterized by excessive deposition of amyloid β-peptides (Aβ peptides) in the brain. In the nonamyloidogenic pathway, the amyloid precursor protein (APP) is cleaved by the α-secretase within the Aβ peptide sequence. Proteinases of the ADAM family (adisintegrin and metalloproteinase) are the main candidates as physiologically relevant α-secretases, but early lethality of knockout animals prevented a detailed analysis in neuronal cells. To overcome this restriction, we have generated transgenic mice that overexpress either ADAM10 or a catalytically inactive ADAM10 mutant. In this report we show that a moderate neuronal overexpression of ADAM10 in mice transgenic for human APP[V717I] increased the secretion of the neurotrophic soluble α-secretase–released N-terminal APP domain (APPsα), reduced the formation of Aβ peptides, and prevented their deposition in plaques. Functionally, impaired long-term potentiation and cognitive deficits were alleviated. Expression of mutant catalytically inactive ADAM10 led to an enhancement of the number and size of amyloid plaques in the brains of double-transgenic mice. The results provide the first in vivo evidence for a proteinase of the ADAM family as an α-secretase of APP, reveal activation of ADAM10 as a promising therapeutic target, and support the hypothesis that a decrease in α-secretase activity contributes to the development of AD.
Biphasic endocardial defibrillation raises the pacing threshold in a steroid-eluting ICD lead
Authors: P.J. Welch, J.A. Joglar, J.D. Zagrodsky, C.J. Sheehan, L.L. Nelson, F.W. Parker, M.H. Hamdan, R.L. Page
Journal: Journal of the American College of Cardiology (1998)
Hematotoxicity and Carcinogenicity of Benzene
Authors: Muzaffer Aksoy
Journal: Environmental Health Perspectives (1989)

The hematotoxicity of benzene exposure has been well known for a century. Benzene causes leukocytopenia, thrombocytopenia, pancytopenia, etc. The clinical and hematologic picture of aplastic anemia resulting from benzene exposure is not different from classical aplastic anemia; in some cases, mild bilirubinemia, changes in osmotic fragility, increase in lactic dehydrogenase and fecal urobilinogen, and occasionally some neurological abnormalities are found. Electromicroscopic findings in some cases of aplastic anemia with benzene exposure were similar to those observed by light microscopy. Benzene hepatitis-aplastic anemia syndrome was observed in a technician with benzene exposure. Ten months after occurrence of hepatitis B, a severe aplastic anemia developed. The first epidemiologic study proving the leukemogenicity of benzene was performed between 1967 and 1973 to 1974 among shoe workers in Istanbul. The incidence of leukemia was 13.59 per 100,000, which is a significant increase over that of leukemia in the general population. Following the prohibition and discontinuation of the use of benzene in Istanbul, there was a striking decrease in the number of leukemic shoe workers in Istanbul. In 23.7% of our series, consisting of 59 leukemic patients with benzene exposure, there was a preceding pancytopenic period. Furthermore, a familial connection was found in 10.2% of them. The 89.8% of our series showed the findings of acute leukemia. The possible factors that may determine the types of leukemia in benzene toxicity are discussed. The possible role of benzene exposure is presented in the development of malignant lymphoma, multiple myeloma, and lung cancer.