tbuckley/cabot-search huggingface dataset:
Maintenance of venous polyethylene catheters to reduce risk of infection
Authors: J. A. Corso
Journal: JAMA (1969)

To evaluate factors of potential importance in reducing the risk of infection secondary to use of venous polyethylene catheters, a prospective study was done to determine local and systemic infection rate associated with their use. During the study period, cultures were taken of all catheters removed and the patients were followed up for phlebitis or infection. Cultures were positive on 26 (5.2%) of 505 of the catheters removed. Staphylococcus albus was found on 16 of the 26 catheters and Staph aureus was found on 8 of the remaining 10. Two cases (0.4%) of catheter-induced bacteremia occurred, both with Staph aureus. The infection rate, defined by catheter cultures, was much lower than that reported in the only similar study known to be available. Adherence to a strict set of regulations for catheter maintenance was the most probable explanation for our comparatively low infection rate.
Gastroenterological Society of Australia
Journal: Gut (1967)

Lopresti fiberoptic oesophagoscope was described.The advantages of the instrument were its relative comfort to the patient, the ease of passage, the excellent magnified image of the oesophagus, and the avoidance of a general anaesthetic.Early experience and diagnosis had proved successful in the demonstration of oesophagitis, carcinoma, stricture, and oesophageal reflux.The instru- ment had also been of use in examination of the stomach as far as the antral region and the cardio-oesophageal junction could also be well seen.A colour cine film was shown to demonstrate views obtained of the oesophagus.
Pulmonary edema in a 52-year-old woman ingesting large amounts of aspirin
Authors: R. M. Liebman
Journal: JAMA (1981)

<h3>History</h3> A 52-year-old woman was brought to the emergency room of Michael Reese Hospital and Medical Center, Chicago, by her husband. She was unable to provide a coherent medical history because of a confused mental state and garbled speech. On the day before admission, the patient underwent a sudden change in personality and mental status, associated with slurred speech and upper extremity tremors. Her medical history indicated chronic headaches, which had been treated with large amounts of aspirin. It was later learned that the week before her illness, she had ingested large quantities of aspirin for a persistent, severe headache. However, on the day before admission, she admitted to taking only one or two tablets. Further inquiry indicated a history of alcohol abuse and psychiatric illness. No history of renal or cardiac disease was obtained. The patient appeared slightly agitated and confused. Her blood pressure was 130/80 mm Hg; her
Attempted Suicide Among High School Students—United States, 1990
Journal: JAMA (1991)

Suicide rates for adolescents 15-19 years of age have quadrupled from 2.7 per 100,000 in 1950 to 11.3 in 1988 (1,2). Data from earlier decades are not available to assess similar trends in rates of attempted suicide in this population. Attempted suicide is a potentially lethal health event, a risk factor for future completed suicide, and a potential indicator of other health problems such as substance abuse, depression, or adjustment and stress reactions (3). This report examines self-reported data to estimate the annual prevalence of suicidal thoughts and behaviors among U.S. high school students.
JAPAN
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The lasting value of clinical skills
Authors: D. C. Kern
Journal: JAMA (1985)

To assess the lasting value of clinical skills learned by residents in a subspecialty-oriented training program in internal medicine, we surveyed recent graduates. Graduates received a questionnaire contrasting separate ratings of the amount of training (preparation) they received during residency with the importance of this training in subsequent career activities. Topics included 12 traditional medical disciplines, 15 areas related to the practice of medicine, 15 allied medical disciplines, ten basic skill and knowledge areas, and 28 technical procedures. Response rate was 91.8% (56/61). Ninety-five percent of respondents had certification from the American Board of Internal Medicine, 80% had subspecialty training, and 89% rendered direct patient care. Fifty-six topics showed disparity between preparation and importance scores (45 with<i>P</i>&lt;.0001). For 14 categories, mainly technical procedures, disparate ratings suggested excessive programmatic emphasis, while for 42 categories, including history taking and physical examination, there may have been inadequate emphasis. These data suggest that basic clinical skills may require greater emphasis, even in traditional programs. The opinion of program graduates is an important resource in designing training programs in internal medicine. (<i>JAMA</i>1985;254:70-76)
Poison Ivy.
Authors: E. S. McKee
Journal: JAMA (1906)

Cincinnati, Ohio, March 16, 1906. <h3>To the Editor:</h3> —In the current issue ofThe JournalA. W. Balch, Washington, passed assistant surgeon, United States Navy, takes exception to my article on "Dermatitis Venenata," abstracted inThe Journal. He says that while I have had<i>Rhus toxicodendron</i>poisoning twice he has had it eighty times. He queries: "Is it possible that the work of Pfaff is not yet known to the profession?" Had he read the original of my article, not the abstract, he would have seen full reference to Pfaff and his work. I should be pleased to read Dr. Balch's experiences with his eighty cases of poisoning from<i>Rhus toxi</i><i>codendron</i>more fully written up.
THE SIGNIFICANCE OF FORMIC ACID EXCRETION
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TYROSINURIA
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
False-negative results of Haemoccult test in colorectal cancer
Authors: C. Griffith, J. H Saunders
Journal: BMJ (1981)

quantitation of blood in the stool provide measure- ments of the false-negativity rate observed in several field trials in recent years.Thus not only is the collection and interpretation of data by Mr Griffith and his colleagues inadequate for the problem addressed but also the test used has distinct limitations of sensitivity.Although the guaiac-impregnated paper kits are more reliable than other tests, which fell into disrepute 20- 30 years ago, the fundamental need for experimental control remains.
Erythropoietic Protoporphyria
Authors: William B. Reed
Journal: JAMA (1970)

A genetic and clinical study was conducted on nine families. There were 16 clinically affected individuals and 43 carriers. A predominance of males in our study and from the literature was noted. Two families showed transmission of the trait from a carrier to an affected individual to a carrier through several generations. Carriers were detected by increased fluorescing erythrocytes because fecal and erythrocyte protoporphyrin levels are often normal. Erythrocytic protoporphyrins are probably not important for photosensitivity, though protoporphyrins from the liver may well be. The disorder should be called erythrohepatic protoporphyria in order to emphasize the complete metabolic defect. The disorder is transmitted as an autosomal dominant with many carriers and few clinically involved individuals.
Sudden Cardiac Death in US Young Adults, 1989-1996
Authors: Zhi-Jie Zheng, Janet B. Croft, Wayne H. Giles, George A. Mensah
Journal: Circulation (2001)

0007 Anecdotal evidence and case reports indicate that sudden cardiac death (SCD) occurs in adolescents and young adults. To investigate the epidemiologic pattern and secular trend of SCD among ages 15-34 years, we analyzed US Multiple Causes of Death data from 1989 to 1996. SCD is defined as death due to cardiac disease (ICD-9 codes: 390-398, 402 and 404-429)that occurred out of hospital or in emergency room. This definition has been used in prior studies with reasonable accuracy. Mortality rates were calculated using mid-year population estimates as the denominators, and standardized to 1970. In 1996, 3,000 sudden cardiac deaths occurred for this specific age group, which reflects a 10% increase from 1989 (n=2,719). The leading underlying causes of SCD were ischemic heart disease (ICD codes 410-414, and 429.2), and arrhythmias or cardiomyopathies (ICD codes 425-427), each accounting for 35% of all SCDs. SCD mortality rates were twice as high in men as in women, and increased with age. From 1989 to 1996, age-standardized SCD mortality rates increased in both men (+10%) and women (+31%) ( Figure). Although SCD is relatively rare in US adolescents and young adults, the increased trend of SCD mortality warrants further investigation. This is the first national surveillance report on SCD in young adults. Figure 1.
B.C.G. Vaccination
Authors: Sol Roy Rosenthal
Journal: JAMA (1969)

This volume, subtitled<i>A Practical Manual for B.C.G. Vaccination</i>, includes not only the personal experiences of the author and his associates during 17 years at the Pilot Station of the International Children's Center in Paris, but also the critical evaluation of the more recent world literature on BCG vaccination. Mande, in an astute and scholarly manner, presents the problems and their possible answers involving the various clinical application of BCG. In various chapters, he takes up such topics as the selection of subjects to be vaccinated; vaccination; postvaccination follow-up; complications; the protection afforded by vaccination; the basic principles of BCG vaccination. In his conclusion, he discusses the place of BCG vaccination in tuberculosis control. After reviewing well-controlled and statistically acceptable studies around the world, he concludes that we can expect a decrease in morbidity of 65% to 85% in the vaccinated. Furthermore, BCG protects against all forms of tuberculosis,
Detection of metastases in breast cancer: Is whole body PET/MR better than PET/CT?
Authors: Komal L. Jhaveri, Eleonora Teplinsky, Francisco J. Esteva, Akshat Pujara, Linda Moy, Amy Melsaether
Journal: Journal of Clinical Oncology (2014)

11002 Background: Whole body (WB)PET/CT is commonly utilized in breast cancer (BC) patients (pts). Limitations include assessment of treatment response in bone metastases (mets), high physiologic uptake in brain and liver, and cumulative radiation exposure. The site of mets can have prognostic and therapeutic implications. PET/MR, an exciting new hybrid technology, delivers less radiation than PET/CT. Our aim was to compare the differences in metastatic lesion detection using PET/CT and PET/MR in all BC subtypes. Methods: Pts who had WB PET/CT for staging and assessment of treatment response also had WB PET/MR after a single 18-FDG injection. PET/MR and PET/CT images were each read by a radiologist blinded to prior exams or reports. The number of mets per organ was recorded. 2 experienced radiologists unblinded to imaging and pathology reports served as the gold standard. Clinical data were obtained. Trial accrual is ongoing. Results: 48 pts underwent PET/CT and PET/MR (28 MBC, 5 neoadjuvant & 15 adjuvant setting). Median age was 48; range 31-79 with 31 ER+/HER2-, 9 ER+/HER2+, 2 ER-/HER+, 5 ER-/HER2-, 1 unknown. 11 pts had no evidence of mets. In remaining 37 pts, PET/MR and/or PET/CT detected bone, liver, or brain mets in 23, 9 and 5 pts, respectively; some patients had ≥1 metastatic site. PET/MR accurately detected 1 bone (ER+/HER2), 3 liver (ER+/HER2-) and 5 brain lesions (2 ER+/HER2-, 2ER-/HER2+, 1ER+/HER2+) in 8 unique pts that were not identified on PET/CT. 2 liver and 2 brain mets identified on PET/MR were previously unknown. PET/MR accurately reported treated bone lesions in 10 pts. Per organ system, there were more false neg and false pos with PET/CT (Table). Conclusions: Our preliminary data suggest that PET/MR may be more sensitive and specific than PET/CT in detecting mets in breast cancer. Prospective studies of PET/MR are warranted to determine whether early detection of mets, including occult brain mets in HER2+ pts, impacts survival. Organ (N)a # Pts with concordant PET/CT & PET/MR findings # Pts with false (+) on PET/CT # Pts with false (-) on PET/CT Bone (23) b 10 9 2 Lung (5) 2 2 1 Pleura (5) 4 1 0 Nodes (axilla + other) (19) 9 6 4 Liver (9) 5 1 3 Brain (5) 0 0 5 aSome pts had ≥1 metastatic site b In 2 pts, neither modality accurately detected the # lesions.
Abstract P111: A Genome-Wide Gene Expression Study of Blood Pressure in Twins
Authors: Yisong Huang, Miina Ollikainen, Jaakko Kaprio, Guang Hao, Shaoyong Su, Xiaoling Wang
Journal: Circulation (2017)

Background: Recently, a genome wide gene expression study identified 34 genes that were differentially expressed in relation to blood pressure (BP). However, to what extend these BP related gene expression signatures are driven by genetic factors or environmental factors have not been investigated. Methods: In this study of 383 twins (84 DZ pairs, 105 MZ pairs and 5 singletons; age 32-69; 40% male) recruited from the Finland Twin Cohort Study, genome-wide gene expression data in peripheral leukocytes were obtained using illumine HT12 V4 array. Systolic and diastolic BP related gene expression changes were identified using linear mixed model. Structural equation modeling was used to estimate the genetic and environmental sources of variance of BP related gene expression signatures. Results: Our genome wide gene expression analysis identified 1 gene ( ECT2 , FDR=0.019) with its expression level associated with SBP and 1 gene ( LMNA , FDR=0.004) with its expression level associated with DBP at the cutoff of FDR&lt;0.05. Out of the previously identified SBP (N=21) and DBP related genes (N=20), 5 genes ( CD97, TAGLN2, MYADM, SL31A2 and TIPARP ) for SBP and 5 genes ( CD97, S100A10, MYADM, TIPARP and SLC31A) for DBPcan be replicated in the twin cohort with same directions and p&lt;0.05. Four genes showed association with both SBP and DBP. Structural equation modeling was conducted on the expression levels of the newly identified BP related genes as well as the ones that were previously identified but can been replicated in this study. Out of the 8 genes, genetic factors contributed significantly to the expression of 2 genes ( LMNA and S100A10 ) and shared environmental factors contributed significantly to the expression of 1 gene ( MYADM ), while for 5 genes, both genetic and shared environmental factors have significant contributions to their gene expression levels. Conclusion: In this study of twins, we identified novel genes with its expression level associated with BP and replicated several previously identified signals. Our study further provides new insights into the genetic and environmental sources of BP related gene expression signatures.
Prognostic value of free testosterone (FT) levels during salvage chemotherapy with carboplatin plus weekly docetaxel in metastatic castration- and docetaxel-resistant prostate cancer (mDRPC)
Authors: C.W.M. Reuter, S. Brunotte, P. Ivanyi, M.A. Morgan, V. Grünwald
Journal: Annals of Oncology (2018)
Letters from the Watering Places of Germany: Marienbad. By an eminent Physician. Letter I
Journal: BMJ (1840)

LEERS "PROM TnIRVA fIUtLAUX3 OPS OH &. 13a i,k tmd cmtrtnue in -dis condition into th* bronehW es end their vamifleatie.The lunswteme highly con- Geuain.riftaryAppaatu.-Th#intrior of the tight kidney pre*ented no ttaces of organitattn, but dontained adar-k grumn3u fluid; the left kidney was healthy.The bMadder was firmly eontracted, and did not contain a drop of urine.Both testicles were distended with emetl, and their excretory ducts Were beautiftlly convoluted, and dis- tended with seminal fluid.Brtin and Medulla Spinad.-Thepia-mater of both was very vascular; the other membranes were natural.The Ventricles of the brai-.contained a table-spoonful of serutn.Eyes.-There was extravasation of blood beneath the right conjunctivc.The left conjunctiva was one sheet of red ftom vascularity, without Any extravasation.
Vitiligo
Authors: L. Juhlin, M.J Olsson
Journal: British Journal of Dermatology (1996)

Journal Article Vitiligo Get access L. Juhlin, L. Juhlin Departments of Dermatology University Hospital. Uppsala, Sweden Search for other works by this author on: Oxford Academic Google Scholar M.J Olsson M.J Olsson Departments of Dermatology University Hospital. Uppsala, Sweden Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 135, Issue 5, 1 November 1996, Page 852, https://doi.org/10.1111/j.1365-2133.1996.tb03901.x Published: 01 November 1996
Reply
Authors: J M Dixon, C P Armstrong, O Eremin
Journal: Gut (1983)

Varicocoele caused by a pancreatic pseudocyst Sir, We were interested to read the case report by Drs Dixon, Armstrong, and Fremin of a varicocoele caused by a pancreatic pseudocyst (Gut 1983; 24: 438-40), but we believe the pancreatogram reproduced in Fig. 1 may have been misinterpreted.While accepting the difficulty of interpreting reproduced radiographs, we believe the appearances shown, and the description in the text of a blind ending to the main pancreatic duct are more suggestive of main pancreatic duct obstruction, a radiological feature which may be seen in the presence of a pseudocyst, rather than the fine terminal arborisation of the duct system more typical of an unfused ventral pancreas.2Although this in no way detracts from the interest of the report we would hesitate to ascribe this patient's recurrent acute pancreatitis to congenital duct malfusion, particularly in the presence of gall stones.
Letter from Spitak, Armenia. A phoenix of peace rises from the ashes
Authors: M. B. Heisler
Journal: JAMA (1989)

At 11:41 AM on December 7, 1988, an earthquake of massive proportions, measuring 6.9 on the Richter scale, struck northern Armenia. The shifting of tectonic plates created a cataclysmic force that erupted near the city of Spitak. The destructive energy was focused on a quiet, wind-swept valley that sits against the shoulder of the Caucasus Mountains. A deafening rumble rose from deep in the earth and the valley floor began to sway violently. The shock continued for 30 seconds. When it stopped, the cities of Spitak, Leninakan, Kirovakan, and Stepanavan and more than 150 villages lay demolished. Eight million square meters of dwelling space had been destroyed, including 35 000 homes. Schools serving 63 000 pupils, hospitals containing 5000 beds, and polyclinics providing services for 8900 patients per day were all destroyed (George Reid, Director, Red Cross Relief Operations, Yerevan, Soviet Armenia, oral communication, December 19, 1988). We were three of
LEPRAPHOBIA.
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal