tbuckley/cabot-search huggingface dataset:
Psychodermatology
Authors: Herman Musaph
Journal: Psychotherapy and Psychosomatics (1974)

A description of the history of psychodermatology and of the three phases of research conceptualization – the anecdotal phase, the methodological phase, and the present integrative phase – are given. A typical example of a psychodermatological approach towards itching and scratching is given, an example which shows that a simple, specific, recurring causal relationship between precipitating factors and reaction patterns does not exist.
一项使用儿童特应性皮炎影响量表研究分数随时间变化的研究
Authors: M. Gabes, S.L. Chamlin, J.‐S. Lai, D. Cella, A.J. Mancini, C.J. Apfelbacher
Journal: British Journal of Dermatology (2020)

特应性皮炎是一种常见的皮肤病,会引起极度瘙痒(称为瘙痒症),主要影响儿童。在美国 (U.S.A.),大约 17% 的小学生被认为患有特应性皮炎,而在北欧,这一比例大约为 16%。 本研究的研究人员位于美国和德国。儿童特应性皮炎影响量表 (CADIS) 是一项问卷,用于衡量特应性皮炎年幼儿童患者及其父母的生活质量。本研究旨在探讨 CADIS 是否能够检测出随时间的流逝发生的变化,以及需要多大变化才能对患者有益。儿童患者的父母完成了 CADIS 并在初次入组时和四个星期后对其小孩的皮肤状况进行了单个问题的评分。 只有皮肤状况改善的儿童在四周后显示出显著改善的 CADIS 评分,即 CADIS 对改善的趋势变化很灵敏。但是,变化的分数必须可解读才具有临床意义。因此,作者计算了最小重要变化 (MIC),这是患者认为有益的最小分数变化。发现 CADIS 改善超过 12% 很有可能代表临床上的重要变化。由于 CADIS 能够测量一段时间内的变化,因此它是临床实践中的有用工具。 本摘要涉及研究:儿童特应性皮炎影响量表的反应性评估以及最小可检测变化和最小重要变化分数的估计
METABOLISM
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of bladder carcinoma
Authors: Ashish M. Kamat, Joaquim Bellmunt, Matthew D. Galsky, Badrinath R. Konety, Donald L. Lamm, David Langham, Cheryl T. Lee, Matthew I. Milowsky, Michael A. O’Donnell, Peter H. O’Donnell, Daniel P. Petrylak, Padmanee Sharma, Eila C. Skinner, Guru Sonpavde, John A. Taylor, Prasanth Abraham, Jonathan E. Rosenberg
Journal: Journal for ImmunoTherapy of Cancer (2017)

The standard of care for most patients with non-muscle-invasive bladder cancer (NMIBC) is immunotherapy with intravesical Bacillus Calmette-Guérin (BCG), which activates the immune system to recognize and destroy malignant cells and has demonstrated durable clinical benefit. Urologic best-practice guidelines and consensus reports have been developed and strengthened based on data on the timing, dose, and duration of therapy from randomized clinical trials, as well as by critical evaluation of criteria for progression. However, these reports have not penetrated the community, and many patients do not receive appropriate therapy. Additionally, several immune checkpoint inhibitors have recently been approved for treatment of metastatic disease. The approval of immune checkpoint blockade for patients with platinum-resistant or -ineligible metastatic bladder cancer has led to considerations of expanded use for both advanced and, potentially, localized disease. To address these issues and others surrounding the appropriate use of immunotherapy for the treatment of bladder cancer, the Society for Immunotherapy of Cancer (SITC) convened a Task Force of experts, including physicians, patient advocates, and nurses, to address issues related to patient selection, toxicity management, clinical endpoints, as well as the combination and sequencing of therapies. Following the standard approach established by the Society for other cancers, a systematic literature review and analysis of data, combined with consensus voting was used to generate guidelines. Here, we provide a consensus statement for the use of immunotherapy in patients with bladder cancer, with plans to update these recommendations as the field progresses.
Cranio-carpo-tarsal dysplasia. Report of a case in father and son
Authors: F. C. Fraser
Journal: JAMA (1970)

The features of whistling face syndrome as it appeared in a father were compared with those found in his infant son. The syndrome is inherited as an autosomal dominant trait. Sporadic cases presumably represent fresh mutations, and will transmit the mutant gene to about half of their children. Siblings of sporadic cases, on the other hand, will have a very low risk of being affected.
HTLV-III Antibodies in US Army Blood Donors in West Germany
Authors: Michael A. Morgenstern
Journal: JAMA (1985)

<h3>To the Editor.—</h3> The recent emphasis on the operating characteristics of the enzyme-linked immunosorbent assay (ELISA) human T-cell lymphotropic virus type III (HTLV-III) antibody test<sup>1-3</sup>and its role as a screening mechanism for the acquired immunodeficiency syndrome (AIDS) presents us with a crucial problem. We fail to see how the sensitivity and/or specificity of a screening test for an infectious disease can be precisely defined in the absence of either data on the true prevalence of infection within a population or a "gold-standard" confirmatory test to identify infection. To date, it seems that the operating characteristics of the HTLV-III ELISA antibody test have been defined (1) on the assumption that antibody seropositivity is a quantitative, predictive measure for viremia; (2) primarily among clinical populations; and (3) assuming, for the most part, the ELISA test itself as the most sensitive available. This is not to say that the HTLV-III antibody
Effects of Chromium on DNA Replication In Vitro
Authors: Elizabeth T. Snow
Journal: Environmental Health Perspectives (1994)

Chromium is an environmentally significant human carcinogen with complicated metabolism and an unknown mechanism of mutagenesis.Chromium(VI) is taken up by cells as the chromate anion and is reduced intracellularly via reactive intermediates to stable Cr(III) species.Chromium(lll) forms tight complexes with biological ligands, such as DNA and proteins, which are slow to exchange.In vitro, CrCI3.6H2Oprimarily interacts with DNA to form outer shell charge complexes with the DNA phosphates.However, at micromolar concentrations, the Cr(1II) binds to a low number of saturable tight binding sites on single-stranded M13 DNA.Additional chromium interacts in a nonspecific manner with the DNA and can form intermolecular DNA cross-links.Although high concentrations of Cr(1II) inhibit DNA replication, micromolar concentrations of Cr(Ill) can sub- stitute for Mg2+, weakly activate the Klenow fragment of E. coli DNA polymerase (Pol l-KF), and act as an enhancer of nucleotide incorporation.Alterations in enzyme kinetics induced by Cr(111) increase DNA polymerase processivity and the rate of polymerase bypass of DNA lesions.This results in an increased rate of spontaneous mutagenesis during DNA replication both in vitro and in vivo.Our results indicate that chromium(llI) may contribute to chromate-induced mutagenesis and may be a factor in the initiation of chromium carcinogenesis.-
THE BLOOD DURING EXERCISE
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The penalty of professionalism
Authors: G. D. Dorman
Journal: JAMA (1969)

As physicians, all of us are well aware and justifiably proud of the advantages of being members of our profession. The conscientious physician probably gets more downright satisfaction out of his work than members of any other field. He also receives more respect and admiration from his fellowman. The reason for both—his personal satisfaction and the honor in which he is held—is that no calling more deeply involves any man with his fellow human beings than medicine. He cares for the organic problems of his neighbors, which is basic to his purpose. In addition, he often is trusted with a view of his patient's heart and soul that is denied to all others. It is not unusual for a physician to know more than a man's wife about his ambition and his fear, his confidence in himself and his secret doubts. A wife will tell her physician things about her
High-dose chemotherapy followed by autologous transplantation may overcome the poor prognosis of diffuse large B-cell lymphoma patients with MYC/BCL2 co-expression
Authors: F Maura, A Guidetti, A Pellegrinelli, A Dodero, M Pennisi, C Caprioli, A Testi, L Farina, N Bolli, L F Devizzi, A Cabras, P Corradini
Journal: Blood Cancer Journal (2016)
Surgery
Authors: C. H. Organ
Journal: JAMA (1990)

Carcinoma of the breast afflicts in excess of 110 000 women in the United States annually. Dramatic improvements in cosmetic results from breast reconstruction have been demonstrated, particularly in the restoration of contour, symmetry, and the areola-nipple complex. A number of centers with extensive reconstructive experience and follow-up of their patients have recommended that immediate reconstruction be routinely offered to women with operable breast cancer because of the positive psychosocial benefits experienced by these patients.<sup>1</sup> The second alert from the National Cancer Institute was issued in 1989 that involved the efficacy and results of adjuvant levamisole and fluorouracil therapy for patients who had Duke's group C colon cancer. In this study, the 5-year recurrence rate in the nontreated group (n = 135) vs the treated group (n = 136) was 55% and 41%, respectively; the median survival to recurrence was 14 months in the nontreated group and 23 months in the
Gulstonian Lectures on Fever and Inflammation
Authors: W. Addison
Journal: BMJ (1859)

of cheesy matter, which was containedl in the ovarian sac, ap- peared on one of the intestines.No pus was found.The liver was adherent to the under surface of the diaphragm.The adhesions were evidently old, and not to be brokcn down.The kidneys were healthy.The heart was very small, and on the rig,ht side very thin-about the eighth of an inch thick.The lungs were perfectly healthy.The os uteri was situ- ated in its normal position, and admitted a sounid for about an inch.The neck of the uterus was situiated about an inlch fronm the body, and was connected with the latter by a sm-all impelvious band of membrane.The uterus itself thus floated in the pelvis, having no direct or continuous communication with the os itself, except through this membranous band.The maiamme were well developed.REMARKS.This case is one of the greatest interest.The disease was evidently congenital, as evidenced by the bony growth; and the rapidity of its development, during the last twelve months, too clearly showed that death would soon follow.At the same tiine, no tapping could have selieved her, and no palliative treatment could have been of the slightest benefit.Although but little hope existed of suiecessful result from ex- tirpation, still it was the only hope; and the patient aiid her frienids elected to run the risk-I think wisely so, because ex- perience proves that, if there be no other organic disease, life is often prolonged or saved by extirpation.In this case, the small and weakl heart evidently had a great deal to do with the deatlh.
Government Services
Journal: JAMA (1929)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
"Reversible" Sterilization
Authors: E. D. Y. Grasby
Journal: BMJ (1964)

Urinary Infections in Pregnancy SIR,-It is disappointing to see the myth of " physiological " urinary tract disturbances in pregnancy resurrected by Mr. Elliot E. Philipp (21 March, p. 749) in spite of his protestation that mild infection may progress to more chronic conditions.To pass over urinary-tract symptoms as being likely to be due to changes in the epithelium of the trigone is to put an unnecessary stumblingblock in the way of the correct diagnosis.E. H. Kass' demonstrated five years ago that quite apart from overt urinary infections asymptomatic bacteriuria occurs in 7% of all pregnant women, and will progress to clinical pyelonephritis in up to 40% of cases within the course of the pregnancy.It is well known that chronic pyelonephritis commonly escapes detection during life, and it may be that prospective studies will establish an association between asymptomatic bacteriuria and subsequent chronic renal disease.In the meantime the clinician should investigate any ,complaint of urinary-tract symptoms, how- ever minor, during pregnancy.Ideally those cases of proved bacteriuria should be followed up after parturition.In fact I would suggest that every pregnant woman is entitled to have at least one properly collected midstream specimen of urine cultured during the first trimester of her pregnancy.-Iam, etc., Edinburgh 3.
Commentaire du travail de Park SW et al., pp. 33
Journal: Endoscopy (2014)

Se Woo Park, Moon Jae Chung, Tak Geun Oh, Jeong Youp Park, Seungmin Bang, Seung Woo Park, Si Young Song. Intramuscular diclofenac for the prevention of post-ERCP pancreatitis: a randomized trial.
THU0098 Long-term effects of rituximab on B-cell counts and autoantibody production in rheumatoid arthritis: Use of high-sensitivity flow-cytometry for more sensitive assessment of B-cell depletion
Authors: A. Váncsa, L. Gergely, Z. Szabό, S. Szilvia, N. Bodnár, E. Végh, G. Szücs, S. Szántό, Z. Szekanecz
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Rituximab (RTX) is a B-cell depleting antibody widely used to treat rheumatoid arthritis (RA). Responses to RTX are in close correlation with the efficacy of B-cell depletion. Therefore the determination of residual B-cell counts is crucial for the efficacy of treatment. <h3>Objectives</h3> Here we wished to assess the efficacy and safety of long-term RTX therapy and study correlations between B-cell depletion, clinical response and autoantibody production. <h3>Methods</h3> Seventy-seven patients with active RA received RTX and were re-treated every six months regardless of clinical response. All patients received at least 5 cycles. We assessed DAS28, IgM rheumatoid factor (RF) and ACPA levels at baseline, after 15 days and then every 6 months for 24 months. Absolute CD19+ B-lymphocyte counts were also determined in 50 patients using high-sensitivity flow-cytometry (hsFACS). <h3>Results</h3> After 6, 12, 18 and 24 months, 51.6%, 51.9%, 73.3% and 83.8% of patients showed good EULAR responses, respectively. Significant and sustained decreases in IgM RF and anti-CCP levels were observed as early as after 6 months and 12 months, respectively. The baseline mean absolute B-cell number was 0.234 G/l. B-cell numbers significantly dropped after the very first infusion by day 15 (0.104 G/l; p=0.007), which further decreased until 24 months (0.0013 g/l; p&lt;0.001). One RTX infusion resulted in incomplete depletion in 76.7% of patients. B-cell numbers positively correlated with DAS28 (r=0.964; p&lt;0.001), IgM RF (r=0.955; p&lt;0.001) and anti-CCP (r=0.755; p&lt;0.01). No safety issues arose. <h3>Conclusions</h3> In RA, clinical response to RTX is associated with the extent of B-cell depletion and with autoantibody production. hsFACS may be a useful method to more accurately assess incomplete B-cell depletion and maybe, as in oncohematology, minimal residual disease. <h3>Disclosure of Interest</h3> None Declared
Manuscripts Approved for JNCI, January–February 1971
Journal: JNCI Journal of the National Cancer Institute (1971)

Manuscripts Approved for JNCI, January–February 1971 Get access JNCI: Journal of the National Cancer Institute, Volume 46, Issue 3, March 1971, Pages 691–692, https://doi.org/10.1093/jnci/46.3.691-a Published: 01 March 1971
Biological Monitoring of Iodine, a Water Disinfectant for Long-Term Space Missions
Authors: Grazyna Zareba, Elsa Cernichiari, Lowell A. Goldsmith, Thomas W. Clarkson
Journal: Environmental Health Perspectives (1995)

In order to establish guidelines for exposure of astronauts to iodine, used as a water disinfectant in space, we studied the usefulness of hair, saliva, and urine for biological monitoring in humans and in the human hair/nude mouse model. The monitoring of iodine in patients that received 150 mCi of Na131I (carrier-free) showed similar patterns of elimination for blood, saliva, and urine. The mean correlation coefficient (r) between iodine elimination for blood/saliva was 0.99, for blood/urine, 0.95, and for saliva/urine, 0.97. The absolute value of iodine concentrations in urine revealed marked variability, which was corrected by adjusting for creatinine levels. The autoradiographic studies of human hair demonstrated that iodine is rapidly incorporated into external layers of the hair root and can be removed easily during washing. These data were confirmed after iodine exposure using the human hair/nude mouse model. Hair does not provide satisfactory information about exposure due to unstable incorporation of iodine. The most useful medium for biological monitoring of astronauts exposed to high doses of iodine in drinking water is urine, when adjusted for creatinine, and saliva, if quantitative evaluation of flow rate is provided.
Hints on the Management of the Commoner Infections.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Manuscripts Approved for JNCI, June 15 to July 15, 1961
Journal: JNCI Journal of the National Cancer Institute (1961)

Manuscripts Approved for JNCI, June 15 to July 15, 1961 Get access JNCI: Journal of the National Cancer Institute, Volume 27, Issue 2, August 1961, Page 486, https://doi.org/10.1093/jnci/27.2.486-a Published: 01 August 1961
CYSTIC KIDNEY AND LIVER.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction
Journal: Circulation (1974)

Mirsky I et al.: Circulation 50: 128, 1974. On page 135, the first sentence should read, "For such patients the method must be modified by performing biplane studies and quantitating segmental pressure-volume curves." Also on page 135, in Appendix 1, the constants α 1 , β 1 , and α 2 are: [see equation in the PDF file]