tbuckley/cabot-search huggingface dataset:
The TRH Gene Is Regulated by Thyroid Hormone at the Level of Transcription in Vivo
Authors: Michelle L. Sugrue, Kristen R. Vella, Crystal Morales, Marisol E. Lopez, Anthony N. Hollenberg
Journal: Endocrine Reviews (2010)

ABSTRACT The expression of the TRH gene in the paraventricular nucleus (PVH) of the hypothalamus is required for the normal production of thyroid hormone (TH) in rodents and humans. In addition, the regulation of TRH mRNA expression by TH, specifically in the PVH, ensures tight control of the set point of the hypothalamic-pituitary-thyroid axis. Although many studies have assumed that the regulation of TRH expression by TH is at the level of transcription, there is little data available to demonstrate this. We used two in vivo model systems to show this. In the first model system, we developed an in situ hybridization (ISH) assay directed against TRH heteronuclear RNA to measure TRH transcription directly in vivo. We show that in the euthyroid state, TRH transcription is present both in the PVH and anterior/lateral hypothalamus. In the hypothyroid state, transcription is activated in the PVH only and can be shut off within 5 h by TH. In the second model system, we employed transgenic mice that express the Cre recombinase under the control of the genomic region containing the TRH gene. Remarkably, TH regulates Cre expression in these mice in the PVH only. Taken together, these data affirm that TH regulates TRH at the level of transcription in the PVH only and that genomic elements surrounding the TRH gene mediate its regulation by T3. Thus, it should be possible to identify the elements within the TRH locus that mediate its regulation by T3 using in vivo approaches.
Digest of the Laws and Regulations in Force in the United States Relating to the Possession, Use, Sale and Manufacture of Poisons and Habit-Forming Drugs.
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Relapsed Acute Myeloid Leukemia in Children and Adolescents: Interim Report of the International Randomised Phase III Study Relapsed AML 2001/01.
Authors: Gertjan J. Kaspers, M. Zimmermann, G. Fleischhack, R. Tamminga, Brenda Gibson, H. Armendariz, M. Dworzak, S. Ha, L. Hovi, A. Maschan, N. Philippe, Bassem Razzouk, C. Rizzari, P. Smisek, Owen Smith, Batia Stark, A. Will, Ursula Creutzig
Journal: Blood (2006)
Corrections
Journal: Circulation Research (1969)

Line 12 should read Corp.); 2.5 ixc tracer alcohol H(CH i ),,_ 1 u COH Line 3 should read in which a u a., are the exponential amplitudes Line after equation 27 should read where w m = a 2 e-' m/T = is the curve fitted ordi-Vol.25, p. 196, column 1 Line 1 of fourth paragraph should read The total input rate I T , equation 24, is the Vol. 25, p. 196, column 2 Line 21 from bottom should read substance.This derivation, because of the Line 14 from bottom should read the same applies to equation 11 (28a).
The Endocrine Society 66th Annual Meeting Quebec City, Quebee, Canada July 1 and 2, 1984
Journal: Endocrine Reviews (1984)

Journal Article The Endocrine Society 66th Annual Meeting Quebec City, Quebec, Canada July 1 and 2, 1984 Get access Endocrine Reviews, Volume 5, Issue 2, 1 April 1984, Page 370, https://doi.org/10.1210/edrv-5-2-370 Published: 01 April 1984
Special Studies in Graduate Medical Education
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Vast High School TB Investigation Required Rapid Statewide Response
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Formaldehyde
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The not-so-sick sinus
Authors: S. Vaisrub
Journal: JAMA (1980)

"Sick sinus syndrome" is an anthropomorphic term. Sickness relates to a person, not an organ or tissue. A component part of the human body can become inflamed, degenerated, hypertrophic, or atrophic, but never sick. Still, despite its inappropriateness, the term has survived 13 years of use since Irene Ferrer<sup>1</sup>introduced it in 1967. Perhaps it is just as well. The disease complex itself is too loosely defined to permit a more accurate label. "Sick sinus" may be anatomically inaccurate as well. Kaplan and associates<sup>2</sup>demonstrated lesions in the extranodal atrial tissue and junctional tissue, as well as the sinus in patients with typical clinical manifestations of the syndrome. Moreover, clinical findings are not always characteristic. The classic tachyarrhythmia-bradyarrhythmia sequence may not be present. Severe bradycardia without any other sinus dysfunction has been also subsumed under this syndrome.<sup>3</sup> Drug therapy of the sick sinus may be perplexingly difficult.
Cell Physiology.
Authors: Frederic T. Jung
Journal: JAMA (1963)

The material in this book is divided into seven sections: functional organization of the cell, cell environment, exchange of materials across the cell membrane, conversions of energy and matter in the cell, irritability and contractility, growth and cell division, and history of cell physiology. Such a listing, however, can scarcely suggest the richness of this material, the clarity of presentation in the book, the wealth of new detail supplied by the electron microscope and other modern instruments, and the importance of the results as applied to everyday medicine. The facts and concepts of cell physiology are not only basic for an understanding of the functions of brain, kidney, and liver, they have immediate applications in problems of skin preparation for surgery, the development of detergents, irrigants, diluents, plasma expanders, and innumerable aspects of the nervous system and special senses. Since the author is careful to stay within his field of
THE COST OF MEDICAL CARE
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Use of a novel technique of cutaneous lavage for diagnosis of Lyme disease associated with erythema migrans
Authors: G. P. Wormser
Journal: JAMA (1992)

<h3>Objective.</h3> —Determining the microbial cause of cellulitis is often difficult. In this study, a novel two-needle lavage technique was used to culture<i>Borrelia burgdorferi</i>from the skin of suspected erythema migrans lesions. <h3>Design.</h3> —The yield of lavage cultures for B burgdorferi was compared with that of a 2-mm skin biopsy sample. <h3>Setting.</h3> —A Lyme disease diagnostic center located in an area in which Lyme disease is epidemic. <h3>Patients.</h3> —Forty-five patients with suspected erythema migrans who had not been treated with antimicrobial agents. <h3>Intervention.</h3> —Cutaneous lavage of the advancing edge of a suspected primary erythema migrans lesion was done for all 45 participants, 33 of whom also had a skin biopsy of the same lesion at an identical (14) or an adjacent (19) site. <h3>Main Outcome Measures.</h3> —Growth of<i>B burgdorferi</i>in in vitro culture. <h3>Results.</h3> —Lavage fluid cultures grew<i>B burgdorferi</i>in 13 (29%) of the 45 cases (95% confidence interval [Cl], 16% to 44%). Among the 33 cases in which both lavage and skin biopsy cultures were done, the yield of lavage culture was less than that of biopsy culture (<i>P</i>&lt;.09, 12/33 vs 20/33). If contaminated cultures are excluded, this difference is significant (<i>P</i>&lt;.05, 12/30 vs 20/27). <h3>Conclusion.</h3> —Cutaneous lavage is a new diagnostic technique for recovery of<i>B burgdorferi</i>from erythema migrans lesions that has potential applicability to other types of cutaneous infections. (<i>JAMA</i>. 1992;268:1311-1313)
Nonobese Diabetic/Severe Combined Immunodeficiency (NOD/SCID) Mouse as a Model System to Study the Engraftment and Mobilization of Human Peripheral Blood Stem Cells
Authors: Johannes C.M. van der Loo, Helmut Hanenberg, Ryan J. Cooper, F.-Y. Luo, Emmanuel N. Lazaridis, David A. Williams
Journal: Blood (1998)
Toxemia Major Problem In Adolescent Pregnancy
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Update in Hospital Medicine
Authors: Bradley E. Flansbaum, Jeanne M. Huddleston
Journal: Annals of Internal Medicine (2003)

Letters7 October 2003Update in Hospital MedicineBradley E. Flansbaum, DO, MPH and Jeanne M. Huddleston, MDBradley E. Flansbaum, DO, MPHFrom Columbia Presbyterian Medical Center; New York, NY 10032; and Mayo Clinic; Rochester, MN 55905.Search for more papers by this author and Jeanne M. Huddleston, MDFrom Columbia Presbyterian Medical Center; New York, NY 10032; and Mayo Clinic; Rochester, MN 55905.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-139-7-200310070-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Reducing problems related to central venous catheter placement is a high priority, and we agree with Dr. Painton that appropriate patient screening is prudent and may help avoid needless line-related complications. Typically, patients with significant comorbid conditions who are seen in the intensive care unit have longer hospital stays, in addition to continued needs for intravenous access. The patients in the study by Merrer and colleagues (1) reflect this and, as a result, required longer placement of both subclavian and femoral lines. The investigators stated that catheters were removed at the discretion of the ICU [intensive care unit] ...References1. Merrer J, De Jonghe B, Golliot F, Lefrant JY, Raffy B, Barre E, . Complications of femoral and subclavian venous catheterization in critically ill patients: a randomized, controlled trial. JAMA. 2001;286:700-7. [PMID: 11495620] CrossrefMedlineGoogle Scholar2. Randolph AG, Cook DJ, Gonzales CA, Pribble CG. Ultrasound guidance for placement of central venous catheters: a meta-analysis of the literature. Crit Care Med. 1996;24:2053-8. [PMID: 8968276] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Bradley E. Flansbaum, DO, MPH; Jeanne M. Huddleston, MDAffiliations: From Columbia Presbyterian Medical Center; New York, NY 10032; and Mayo Clinic; Rochester, MN 55905. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoUpdate in Hospital Medicine Bradley E. Flansbaum and Jeanne M. Huddleston Update in Hospital Medicine Todd Painton Metrics 7 October 2003Volume 139, Issue 7Page: 603KeywordsAdverse eventsCathetersHospital medicineIntensive care unitsResuscitationUltrasound imaging ePublished: 7 October 2003 Issue Published: 7 October 2003 Copyright & PermissionsCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Abstract 18018: Clinical Predictors of Acute Kidney Injury After Lower Extremity Surgical Bypass in the Society for Vascular Surgery Vascular Quality Initiative
Authors: Erica Flores, Ke Chen, Juan Pablo Lewinger, Leonardo Clavijo, David Shavelle, Vincent Rowe, Karen Woo, Parveen Garg
Journal: Circulation (2015)

Introduction: The incidence and factors associated with acute kidney injury (AKI) development after lower extremity bypass (LEB) are not well defined. The objective of this study is to determine the incidence and characteristics associated with the development of AKI in patients undergoing infrainguinal LEB. Methods: A retrospective review of all LEB surgeries in the Vascular Quality Initiative (VQI) registry from January 2003 to April 2015 was performed. AKI was defined as post-operative rise in creatinine (Cr) &gt; 0.5 mg/dl or new renal impairment requiring dialysis. Demographic, procedural and clinical variables were collected. Patients on dialysis and those missing pre and post-operative Cr values were excluded. Multivariate logistic regression analysis was performed to identify variables associated with the development of AKI following LEB. Results: 12,564 patients were included in the analysis; 509 (4%) developed AKI. Comparison of baseline characteristics between patients that developed AKI and those that did not are shown in the Table. In multivariate analysis, diabetes (OR 1.57, p&lt;0.01), history of heart failure (OR 1.60, p&lt;0.01), emergency surgery (OR 1.34, p&lt;0.01), need for blood transfusion (OR 2.41, p&lt;0.01) and chronic kidney disease (CKD) stages 2 (OR 1.39, p&lt;0.01), 3(OR 2.85, p&lt;0.01), and 4(OR 5.46, p&lt;0.01) were all significantly associated with AKI. Factors associated with a lower incidence of AKI included smoking (OR 0.72, p&lt;0.05), female gender (OR 0.69, p&lt;0.01) and higher hemoglobin levels (OR 0.92, p&lt;0.01). Conclusions: Overall, the development of AKI in a large contemporary database was 4%. Multiple clinical characteristics are associated with development of AKI, including history of heart failure, diabetes, CKD, emergency surgery and need for blood transfusion, and may help to identify at-risk patients. Further studies are needed to prospectively validate these findings and determine if postoperative AKI increases the mortality risk.
Joseph Pancoast (1805-1882), surgeon and anatomist
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Chicago Exhibition.
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
STRESS IN HELICOPTER PERSONNEL
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal