tbuckley/cabot-search huggingface dataset:
Genes Involved in Initial Follicle Recruitment May Be Associated with Age at Menopause
Authors: Marlies Voorhuis, Frank J. Broekmans, Bart C. J. M. Fauser, N. Charlotte Onland-Moret, Yvonne T. van der Schouw
Journal: Endocrine Reviews (2010)

Timing of menopause is largely influenced by genetic factors. Because menopause occurs when the follicle pool in the ovaries has become exhausted, genes involved in primordial follicle recruitment can be considered as candidate genes for timing of menopause. The aim was to study the association of 23 tagging single nucleotide polymorphisms in five genes (AMH, AMHR2, BMP15, FOXL2, and GDF9) involved in recruitment of the primary follicle pool, including the AMHR2 gene, which has recently been associated with age at menopause. We conducted a cross-sectional association study. Setting and Participants: We studied a population-based sample of 3616 Dutch women with natural menopause. We measured age at natural menopause. Both studied AMHR2 tagging single nucleotide polymorphisms (rs2002555 and rs11170547) in the AMHR2 gene were associated with age at natural menopause in interaction with parity. Parous rs2002555 G/G carriers had menopause 1 yr later compared with A/A carriers (P = 0.01). For rs11170547, each minor allele (T) was associated with a 0.41-yr later onset of menopause in parous women (P = 0.01). Additionally, rs6521896 in BMP15 was associated with later menopause (β = 0.41; P = 0.007). Variants in the AMH, FOXL2, and GDF9 genes were not associated with timing of menopause. The present study confirms an earlier finding that variation in the AMHR2 gene modifies the relation between parity and age at natural menopause. In combination with the association of BMP15 with menopausal age, we find that there is evidence that genes involved in primary follicle recruitment influence timing of menopause.
Patologia de la Hipófisis.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The incidence and outcome of patients presented with edge restenosis after intracoronary radiation therapy Han-Soo Kim, Andrew E. Ajani, Ron Waksman, Lowell F. Satler, Gary S. Mintz, Augusto D. Pichard, Luis Gruberg, Rosanna C. Chan, Kenneth M. Kent. Washington Hospital Center, Washington, DC
Journal: Journal of the American College of Cardiology (2001)
The Sin of Treating Symptoms
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical Lecture Delivered at King's College Hospital, October 13th, 1860
Authors: L. Beale
Journal: BMJ (1860)

tributed somaething to the common stock of information, this meetitig will not have congregated in vain.The British Medi- cal Association may be the instrument of disseminating a valuable mode of curing disease, and thus give proof of its utility as an association, by adding a powerfiil remedy to our Materia Medica, and enlarging the nuimber of all those means and appliances the great object of which is the welfare of man- kind, in the alleviation of human suffering, and the extension of longevity.
Junior Members Forum: "In the rear and limping a little?" Relationship of ethics and law to medicine
Journal: BMJ (1986)

In the rear and limping a little?"Relationship of ethics and law to medicine Ethics and the law seem to surface with remorseless regularity in any medical discussion nowadays.The speakers at last weekend's Junior Members Forum proved this point, provoking much vigorous discussion in the process.Held in Ambleside and chaired by Dr Gordon Parker, a general practitioner in Morecambe, the forum had invited four speakers to talk about medicine, ethics, and the law.It was one of the later speakers, Sir Zelman Cowen, who declared that on subjects such as human tissue transplantation "the law marched with medicine but in the rear and limping a little."It proved an apt summary of the day's proceedings.Opening the conference, the Reverend Professor Gordon Dunstan described the government as distancing itself from medi- cine so far as ethics were concerned.There had, however, been-so far unsuccessful attempts in private members' Bills to control infertility treatment in this country, and in Victoria, Australia, a doctor could be imprisoned for four years for working with embryos.Emeritus professor of moral and social philosophy at King's College, London, Professor Dunstan believed that after the Warnock report parliamentary activity on in vitro fertilization and research was inevitable and probably desirable, but should it be enabling or restrictive?Another source of control was the courts.Although doctors were not much given to litigation, patients were increasingly taking doctors and health authorities to law.In cases of negligence the process was more advanced in the United States, but it was a real threat in this country and would lead to defensive medicine and an erosion of trust.
Contents
Authors: Karani Vimaleswaran, Venkatesan Radha, Munuguru Gopal Jayapriya, Saurabh Ghosh, Partha Majumder, M Rao, Viswanathan Mohan, Angelo Cefalù, Pier Calvo, Davide Noto, Maurizio Baldi, Vincenza Valenti, Pietro Lerro, Fabio Tramuto, Antonella Lezo, Isabella Morra, Giovanna Cenacchi, Cristiana Barbera, Maurizio Averna, Ya-Yu Wang, Shih-Yi Lin, Yu-Han Chuang, Chia-Hung Mao, Kwong-Chung Tung, Huey-Herng Sheu
Journal: Metabolism (2010)
Costly Cancer Care
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Subgaleal hematoma. A complication of instrumental delivery
Authors: W. C. Plauche
Journal: JAMA (1980)

Subgaleal hematomas (SGH) are rare but potentially fatal accumulations of blood beneath the galea aponeurotica of the scalp in the newborn. One hundred twenty-three SGH cases are summarized from the literature. Sixty-four percent occurred after instrumental delivery. The lesion is most often associated with mid-forceps operations (14 cases) and vacuum extraction (60 cases), but SGH also has been recorded after spontaneous vaginal delivery (35 cases) and after cesarean section (11 cases). Intrapartal hypoxia of the fetus and neonatal coagulopathies are prominent features of both spontaneous and instrumental delivery cases. Other risk factors include prematurity, macrosomia, prolonged labor, cephalopelvic disproportion, primiparity, male sex, and African lineage. Mortality for SGH is 22.8%. Early recognition, differentiation from benign cephalohematoma, and prompt treatment by adequate blood replacement and correction of coagulopathies are the major determinants of successful management. (<i>JAMA</i>244:1597-1598, 1980)
Sodium, potassium, and rate constants for sodium efflux in leucocytes from hypertensive Jamaicans
Authors: T. E Forrester
Journal: BMJ (1981)

Leucocyte sodium and potassium content and concen- trations were measured along with ouabain-sensitive and ouabain-insensitive rate constants for sodium efflux in 14 controls and 20 black patients with essential hypertension.Leucocyte sodium content was significantly increased in the patients (mean 101-1±7-8 mmol/kg dry solids v 745 + 76 mmol/kg dry solids; p <0 05), whereas the rate constants for sodium efflux were not significantly reduced.There was no difference between the two groups in cell potassium values.The increase in leucocyte sodium content in the presence of normal rate constants for sodium efflux suggests an increase in membrane permeability to sodium, which might be important in the pathogenesis of essential hypertension.
Abstract P230: Individual and Cumulative Effect of Type 2 Diabetes Associated Genetic Variants on the Risk Of Cardiovascular Disease
Authors: Anders Borglykke, Niels Grarup, Thomas H Sparsø, Allan Linneberg, Mogens Fenger, Jørgen Jeppesen, Torben Hansen, Oluf Pedersen, Torben Jørgensen
Journal: Circulation (2012)

Hypothesis Since type 2 diabetes is a major risk factor for cardiovascular disease (CVD) we hypothesised that diabetes associated single nucleotide polymorphisms (SNP) might be associated with increased risk of CVD. Aim To asses the individual and combined effect of 46 type 2 diabetes associated SNPs on the risk of incident CVD independently of diabetic status. Methods Data from the first Danish MONICA study was used (N=3753) and results were reproduced using the Inter99 study (N=6169). Using Cox proportional hazard regression adjusted for sex and with age as the underlying time-scale the individual effect of each SNP on incident CVD was analyzed. Risk was presented as hazard ratios (HR) per risk allele. Furthermore, the cumulative effect of the 46 SNPs was assessed by adding the number of diabetes risk increasing alleles to a genetic sum score. Both the single and cumulative effect was adjusted for diabetic status in order to see if any possible association with CVD persisted or if the effect was mediated through diabetes. Results During 74,386 person years 1411 incident cases of CVD (fatal and non-fatal) was registered in the MONICA study. In Inter99 729 events was registered during 51,976 person years. In the Danish MONICA study seven genetic variants were significantly associated with incident CVD independently of known diabetic status; SLC2A2 (HR 1.12, 95% CI 1.001-1.26), DGKB (1.11, 1.02-1.2), C2CD4A (1.11, 1.02-1.20), GCKR (1.10, 1.01-1.20), KLF14 (1.12, 1.03-1.21), NOTCH2 (1.16, 1.02-1.32) and JAZF1 (1.10, 1.02-1.20). The genetic score was significantly associated with increased risk of CVD (1.03, 1.02-1.05) per risk increasing allele. In Inter99 three genetic variants were found to be associated with risk of CVD independently of diabetes; SLC2A2 (1.24, 1.07-1.43), CDC123 (0.84, 0.73-0.97) and HNF1B (1.16, 1.03-1.29). The genetic score was not significantly associated with CVD. The results persisted after further adjusting for possible mediating factors like BMI, total cholesterol, HDL cholesterol and blood pressure. Conclusions We found in both studies several diabetes associated genetic variants significantly associated with an increased risk of incident CVD. The SLC2A2 (rs11920090) genetic variant was the only variant that was found to be significantly associated in both studies. This association persisted after adjusting for diabetic status suggesting an effect on CVD beyond the increased risk of diabetes. This potential pathway needs further exploration.
Physician support personnel in the 70's--economic implications
Authors: C. N. Theodore
Journal: JAMA (1970)

As accelerated demand continues to outstrip the supply of services in the 1970's, American medicine is confronted by two problems: (1) how to increase the availability of services, and (2) how to contain the rising prices. It has been suggested recently that the introduction of physician's assistants on a massive scale will help to solve the imbalance of supply and demand by first, increasing the number of personnel and second, expanding the efficiency of existing manpower. It is necessary to do both to meet the challenge of the 1970's. When physicians recognize that they may increase their productivity and their number of patients through the utilization of assistants, additional demand for support personnel will be created. To those who doubt this concept, we need merely point out that it is not new in American medicine. Its prototype existed in many individual practices long before the formal establishment of physician's assistant
Validation of diagnostic usefulness of the spot urine Na/K ratio for replacement of 24-hour urine NA excretion in cirrhotic patients with ascites
Authors: Jinwook Lee, Jae-Seok Hwang, Woo Jin Chung, Heonju Lee, Jung Gil Park, Changhyeong Lee, Byung Seok Kim, Jung Eun Song, Young Oh Kweon, Won Young Tak, Soo Young Park, Se Young Jang, Jeong Ill Suh, Byoung Kuk Jang
Journal: Journal of Hepatology (2020)
Age, sex, and functional impairment predicted risk for mortality in incident dementia at 14 years
Authors: David W. Molloy
Journal: Annals of Internal Medicine (2008)

ACP Journal Club15 July 2008Age, sex, and functional impairment predicted risk for mortality in incident dementia at 14 yearsDavid W. Molloy, MDDavid W. Molloy, MDSt. Peter's Centre for Studies on Aging, Hamilton, Ontario, Canada (D.W.M.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-149-2-200807150-02013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationXie J, Brayne C, Matthews FE. Survival times in people with dementia: analysis from population based cohort study with 14 year follow-up. BMJ. 2008;336:258-62. https://pubmed.ncbi.nlm.nih.gov/18187696Clinical Impact RatingsGIM/FP/GP: Hospitalists: Geriatrics: Neurology: Author, Article, and Disclosure InformationAffiliations: St. Peter's Centre for Studies on Aging, Hamilton, Ontario, Canada (D.W.M.)This article was published at Annals.org on 1 July 2008. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 July 2008Volume 149, Issue 2Page: JC1-13KeywordsCohort studiesDementiaGeriatricsHealth careMultivariate analysisQuality of lifeResearch fundingSurvival analysis ePublished: 15 July 2008 Issue Published: 15 July 2008 CopyrightCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Better surgical training.
Journal: BMJ (1969)

MWICALJURAstarted about a day after the illness began.Three of those given placebo recovered rapidly, while eight of the nine treated patients did so.The general impression of the speed of recovery was confirmed by a detailed analysis of the rate of return of temperature and certain symptoms and signs to normal.It remains to be seen whether these results can be confirmed elsewhere.If they can they are of considerable theoretical interest, for it used to be accepted dogma that antiviral drugs would be effective only if used prophylactically.However, in most respects aspirin would probably have improved these patients as much as the specific drug.The isoquinoline drugs have also been tested further.One report by S. E. Reed and colleagues4 showed that U.K.2371 had not affected volunteers given recent strains of influenza virus, presumably because they were less sensitive than the strains previously used.On the other hand, a preliminary report indicated that U.K.2054 might have some-effect if given by intranasal instillation,5 and this possibility deserves further study.But the intranasal administration of antiviral substances may not always be effective, for the Scientific Committee on Interferon6 has given purified and potent human interferon to monkeys and found that, while it prevents vaccinia virus infection if given in the skin and delays yellow-fever viraemia if given intravenously, it has little effect if given intranasally on infection by a very interferon-sensitive rhinovirus.As human interferon is difficult to prepare except in small quantities it is unlikely to be used in the treatment of influenza.Much interest has developed in the U.S.A. in the possible use of polyinosinic: polycytidylic acid (poly I: C) as an inducer of interferon.It has some toxic effects if given parenterally, but is in fact more effective in preventing influenza in mice if given intranasally than by injection.The results of preliminary studies in man may be expected soon.In Great Britain there is more interest in the possibility of inducing interferon with double-stranded R.N.A. obtained from Penicillium cultures.It has yet to be shown that this material is suitable for human use and effective against human influenza.
A VICIOUS MEDICAL PRACTICE BILL
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mitogen-Inducible Gene-6 Is a Multifunctional Adaptor Protein with Tumor Suppressor-Like Activity in Papillary Thyroid Cancer
Authors: Chi-Iou Lin, Jinyan Du, Wen Shen, Edward E. Whang, David B. Donner, Nick Griff, Frank He, Francis D. Moore, Orlo H. Clark, Daniel T. Ruan
Journal: Endocrine Reviews (2011)

Low tumoral expression of mitogen-inducible gene-6 (Mig-6) is associated with papillary thyroid cancer (PTC) recurrence after thyroidectomy. We hypothesize that Mig-6 behaves as a tumor suppressor in PTC. Mig-6 expression and promoter methylation status were compared in 31 PTC specimens with matched normal thyroid tissue from the same patient. The impact of Mig-6 loss and gain of function on nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) activation, global tyrosine kinase phosphorylation, and cellular invasion was determined in vitro. Mig-6 protein was abundant in all normal thyroid specimens, whereas 77% of PTC had low Mig-6 expression. Mig-6 promoter methylation was found in 79% of PTC with low Mig-6 expression. Low Mig-6 expression in PTC specimens was associated with low NF-κB activity but high levels of EGFR and ERK phosphorylation. Mig-6 expression inversely correlated with PTC size but had no association with other clinicopathological variables including age, extrathyroidal extension, lymphovascular invasion, or histological subtype. Mig-6 knockdown in thyroid cancer cell lines resulted in EGFR phosphorylation and diminished NF-κB activity, whereas Mig-6 overexpression had the opposite effects. Mig-6 knockdown activated ErbB2, Met, and Src phosphorylation. Furthermore, Mig-6 regulated ERK phosphorylation independent from its effects on EGFR. Mig-6 knockdown promoted cellular proliferation, as determined by clonogenic survival. Lastly, Mig-6 knockdown increased matrix metalloproteinase-2 and -9 activities and increased cellular invasion. Mig-6 has tumor suppressor-like activity in PTC. In vivo studies are required to confirm that Mig-6 is a putative tumor suppressor in PTC, and future studies should investigate the utility of Mig-6 as a diagnostic marker.
A VALUABLE CONTRIBUTION OF ANIMAL EXPERIMENTATION
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal