tbuckley/cabot-search huggingface dataset:
Anti CXCR4 antibody combined with activated and expanded natural killer cells for sarcoma immunotherapy.
Authors: Maria Vela
Journal: Journal of Clinical Oncology (2018)

11541 Background: Metastasis occurs in 20-55% of sarcoma patients and remains the main cause of death. We propose a novel immunotherapeutic approach based in anti CXCR4 antibody MDX1338 (Bristol Myers Squibb) in combination with Activated and Expanded Natural Killer (NKAE) cells therapy. CXCR4 is upregulated in 33.3-73.3% sarcomas. Its signaling blockade by MDX1338 may reduce tumor growth and metastatic burden. NKAE cells have shown cytotoxicity against osteosarcoma and Ewing sarcoma. Methods: Expression of CXCR4 by different sarcoma cell lines was analyzed by flow cytometry. Its migration and invasion capacity towards CXCL12 was tested using Transwell plates and Matrigel. NKAE cells were obtained coculturing healthy donors' peripheral blood mononuclear cells with K562-mb15-41BBL cells and IL-2. Rhabdomyosarcoma cells were inoculated intravenously in immunodeficient NSG mice to generate an in vivo model of metastatic sarcoma. Four treatment arms were established: MDX1338; NKAE; MDX1338+NKAE; vehicle. Luminiscent tumors were monitored and subsequently micrometastasis were identified and quantified: by qRT-PCR; by immunohistochemistry; and by fluorescence in situ hybridization. Results: Alveolar rhabdomyosarcoma RH30 cell line showed the highest CXCR4 expression, concomitant with highest migration and invasion index. Both MDX1338 and NKAE efficiently reduced in vitro RH30 cells migration and invasion, but only the combination of both agents completely abrogated it. In in vivo assays, NKAE treatment was enough to completely prevent RH30 tumor implant. Nontheless, qRT-PCR analysis found RH30 lung micrometastasis in NKAE-treated mice group. Again, the combination of both MDX1338 and NKAE was necessary to completely eliminate it. Immunohistochemical and in situ hybridization analysis further confirmed these results. Conclusions: Our in vitro and in vivo studies show a complementary role of anti CXCR4 antibody MDX1338 and NKAE cell therapy to prevent rhabdomyosarcoma cells migration, invasion, tumor implant and lung metastasis formation. These preclinical results constitute a first evidence of the efficacy of this combined immunotherapy to prevent sarcoma disease dissemination.
Confidence Intervals for Effect Parameters Common in Cancer Epidemiology
Authors: Tosiya Sato
Journal: Environmental Health Perspectives (1990)

This paper reviews approximate confidence intervals for some effect parameters common in cancer epidemiology. These methods have computational feasibility and give nearly nominal coverage rates. In the analysis of crude data, the simplest type of epidemiologic analysis, parameters of interest are the odds ratio in case-control studies and the rate ratio and difference in cohort studies. These parameters can estimate the instantaneous-incidence-rate ratio and difference that are the most meaningful effect measures in cancer epidemiology. Approximate confidence intervals for these parameters including the classical Cornfield's method are mainly based on efficient scores. When some confounding factors exist, stratified analysis and summary measures for effect parameters are needed. Since the Mantel-Haenszel estimators have been widely used by epidemiologists as summary measures, confidence intervals based on the Mantel-Haenszel estimators are described. The paper also discusses recent developments in these methods.
Incorrect Affiliation
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 1941: Level and Value of Circulating Endothelial Progenitor Cells in Patients after Acute Ischemic Stroke
Authors: Yip Hon-Kan
Journal: Circulation (2007)

Background and Purpose Endothelial progenitor cells (EPCs) migrate from bone marrow to systemic circulation in response to tissue ischemia where they differentiate into mature endothelial cells for in situ angiogenesis. This study tested the hypothesis that the level of circulating EPCs is substantially increased and predictive of prognostic outcomes after acute ischemic stroke. Methods The level of circulating EPCs [staining markers: CD31/CD34 (E 1 ), CD62E/CD34 (E 2 ) and KDR/CD34 (E 3 )] was examined using flow cytometry at 48 h after acute ischemic stroke in 138 consecutive patients. The EPC level was also evaluated once in twenty healthy volunteers and in forty at-risk controls. Results Level of circulating EPCs (E 1–3 ) was significantly higher in ischemic stroke patients than in at-risk control subjects ( p &lt;0.05). Additionally, EPC (E 1–3 ) level was significantly lower in patients with severe neurological impairment [defined as a score ≥12 on the National Institute of Health Stroke Scale (NIHSS)] than in patients with less severe impairment (NIHSS &lt; score 12) at 48 h after ischemic stroke ( p &lt;0.0001). Moreover, the EPC (E 3 ) level was strongly correlated with improved NIHSS ≥ 4 on day 21 after ischemic stroke ( p =0.0004). Furthermore, low circulating EPC level was independently predictive of severe neurological impairment (NIHSS ≥ 12) at 48 h (E 1–3 ) and combined major adverse clinical outcomes (defined as recurrent ischemic stroke, any cause of death, or NIHSS of ≥ 12) on day 90 (E 1 ) following ischemic stroke ( p &lt;0.001). Conclusions Level of circulating EPCs is independently predictive of prognosis after ischemic stroke.
THE COUNTY SOCIETY AND THE ORGANIZATION MOVEMENT.
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Veterans Have Higher Arthritis Rates Than Civilians
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Specific targeting of human hepatocellular carcinoma cells by immunoliposomes in vitro*1, *2
Authors: D MORADPOUR
Journal: Hepatology (1995)

The monoclonal antibody AF-20 was raised against the human hepatocellular carcinoma (HCC) cell line FOCUS and binds with high affinity to a rapidly internalized 180-kd homodimeric glycoprotein that is abundantly expressed on the surface of human HCC and other human cancer cell lines. Immunoliposomes were produced by covalently coupling AF-20 to liposomes containing carboxyfluorescein. Interaction of immunoliposomes with various HCC cell lines in vitro was quantitatively assessed by flow cytometry and qualitatively analyzed by fluorescence microscopy. Liposomes bearing an isotypematched nonrelevant monoclonal antibody (MAb) and cell lines not expressing AF-20 antigen served as controls. AF-20-immunoliposomes specifically bound to HCC and other human cancer cell lines expressing the AF-20 antigen and were rapidly internalized at 37°C. Interaction of AF-20-conjugated liposomes with these cell lines was between 5 and 200 times greater than that of unconjugated liposomes, whereas no difference was observed between control liposomes bearing a nonrelevant antibody and unconjugated liposomes. Specificity of liposome-target cell interaction was confirmed by competitive inhibition assays. Kinetic analysis showed rapid association of AF-20 immunoliposomes with target cells, with saturation conditions being reached after 60 minutes. We conclude that the MAb AF-20 directs highly efficient, specific, and rapid targeting of immunoliposomes to human HCC and other human cancer cell lines in vitro. This targeted liposomal delivery system represents a promising approach for the development of immunotargeted diagnosis and therapy strategies against HCC.
LAW AND MEDICINE
Authors: Edwin J. Holman
Journal: JAMA (1969)

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Medical Organization
Authors: Walter B. Martin
Journal: New England Journal of Medicine (1954)

MEDICINE is not static. Neither can the practitioner of medicine remain static. However well prepared he may be on entering the profession, he will either advance or retreat from that point. If he is to grow he must constantly strive to improve his knowledge of the science of medicine, broaden and consolidate his experience and perfect his technic in the art of its practice. Medicine is also a social force and is played upon by other social forces, which will, to a high degree, determine the environment in which medicine is practiced and will stimulate or retard its progress. Social . . .
Retinal Cinematography Using Modified Zeiss Camera
Journal: JAMA (1963)

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366. Combining Delivery of GLP-1 Gene Expressing Plasmid and DPP-4 Gene Silencing siRNA Using Chitosan-Based Nanoparticles for Type-2 Diabetes Treatment
Journal: Molecular Therapy (2014)

Iand survival.Systolic blood pressure (p<0.05),heart rate (p<0.05) and body temperature control (p<0.05) were also normalized.Hyperactivity, which was observed in the AAV9 treated mice, was not observed.In conclusion, we demonstrated that a systemic gene therapy could treat a neurotransmitter defi ciency disease.
Detection and surveillance of colorectal cancer
Authors: D. E. Fleischer
Journal: JAMA (1989)

Colorectal cancer is the second most common cause of cancer in the United States. The overall mortality rate approaches 60%. However, the detection of early lesions results in a mortality rate of 20% or less. Therefore, if improvement in survival is to occur, increased efforts need to be focused not only on primary prevention but also on early detection of malignant lesions and the eradication of potentially malignant lesions. There is no universal consensus as to how this can be accomplished. The purpose of this article is to serve as a guideline, providing a practical basis for improving early detection and management of colorectal cancer and its precursors. (<i>JAMA</i>1989;261:580-585)
The Traditional Toxicologic Paradigm Is Correct: Dose Influences Mechanism
Authors: Jay I. Goodman
Journal: Environmental Health Perspectives (1998)

Dose influences mechanism; and over a wide range of doses, one can envision that mechanism will change with changing dose.This basic concept in toxicology is juxtaposed with the biologic importance of maintaining normal DNA methylation status to provide the focus of this paper.The idea that altered DNA methylation plays a variety of roles in carcinogenesis is compatible with three key features of this multistage process: clonal selection of abnormal cells in a progressive fashion, the reversibility of tumor promotion, and the multiplicity of tumor phenotypes.A relatively low capacity to maintain normal methylation status appears to explain, in part, the high propensity of the B6C3F1 mouse to develop liver tumors.This observation supports the view that a mouse liver tumor response is not an appropriate end point for human risk assessment.Additionally, it is suggested that altered DNA methylation can be viewed as a secondary mechanism underlying carcinogenesis.The knowledge that a chemical is acting by a mode of action involving a secondary mechanism can be used to support a safety factor or multiplicity of exposure approach to risk assessment.
&lt;TITLE&gt;Ending tobacco dependence&lt;/TITLE&gt;
Journal: JAMA (1999)

and the AMA.The information and recommendations appearing on this page are appropriate in most instances; but they are not a substitute for medical diagnosis.For specific information concerning your personal medical condition, JAMA and the AMA suggest that you consult your physician.This page may be reproduced noncommercially by physicians and other health care professionals to share with patients.Any other reproduction is subject to AMA approval.
PROPOSED MIDWIFE ACT IN NEW ZEALAND.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Contributions of β-Cell Dysfunction and Insulin Resistance to the Pathogenesis of Impaired Glucose Tolerance and Impaired Fasting Glucose
Authors: Muhammad A. Abdul-Ghani, Devjit Tripathy, Ralph A. DeFronzo
Journal: Diabetes Care (2006)

Impaired glucose tolerance (IGT) and impaired fasting glucose (IFG) are intermediate states in glucose metabolism that exist between normal glucose tolerance and overt diabetes. Epidemiological studies demonstrate that the two categories describe distinct populations with only partial overlap, suggesting that different metabolic abnormalities characterize IGT and IFG. Insulin resistance and impaired β-cell function, the primary defects observed in type 2 diabetes, both can be detected in subjects with IGT and IFG. However, clinical studies suggest that the site of insulin resistance varies between the two disorders. While subjects with IGT have marked muscle insulin resistance with only mild hepatic insulin resistance, subjects with IFG have severe hepatic insulin resistance with normal or near-normal muscle insulin sensitivity. Both IFG and IGT are characterized by a reduction in early-phase insulin secretion, while subjects with IGT also have impaired late-phase insulin secretion. The distinct metabolic features present in subjects with IFG and IGT may require different therapeutic interventions to prevent their progression to type 2 diabetes.
Immunology III
Authors: Janine M. Jason
Journal: JAMA (1985)

The preface to this book states that it is directed to "students at many levels: the undergraduate, the graduate, and the post-graduate." In addition to addressing a wide audience, this book presents a breadth of topics concerning the principles of immunology, the mechanisms of immunologic responsiveness, and the clinical applications of immunology, based on the contributions of more than 20 authors. This represents an ambitious undertaking, at which the various authors succeed to varying degrees. The pivotal chapter concerning immunogenetics is at times disorganized but has an excellent, short section concerning the T-cell receptor. The chapter on immunophysiology is in general extremely good but somewhat outdated concerning research on T-cell receptors and sometimes does not clearly distinguish data from murine and human systems. The chapter on antigen antibody interactions is clear and practical, while the chapter concerning antibodies and immunoglobulins would be improved by an expansion of the discussion on
Reports and Analyses in Medicine, Surgery, Dietetics, and the Allied Sciences
Journal: BMJ (1871)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following Reports and Analyses in Medicine, Surgery, Dietetics, and the Allied Sciences Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Old human centrifuge: forebear of new scanner
Journal: JAMA (1980)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Exclusive breast feeding is protective against asthma and atopy in children
Journal: BMJ (1999)

Evidence for cerebral dysfunction in people after the Camelford water incident Just over 11 years ago 20 tonnes of aluminium sulphate were accidentally added to the drinking water reservoir serving 20 000 people in the Camelford area of Cornwall.There was delay in reporting the incident to the public, and those exposed started reporting various acute symptoms.Later, they started complaining of loss of concentration and short term memory, but in two sittings of a commission of inquiry their symptoms were attributed to anxiety.On p 807 Altmann et al report the results of studies done on 55 affected people who showed objective evidence of cerebral dysfunction.Anxiety levels had no effect, and unexposed siblings performed normally.Although no measures were available from before the incident, their accounts and the discrepancy with their premorbid IQ suggest that these individuals were affected by the incident, and it is likely that aluminium, as the major neurotoxic agent involved, led to the changes observed.