tbuckley/cabot-search huggingface dataset:
Sammlung psychiatrischer und neurologischer Einzeldarstellungen.
Journal: JAMA (1933)

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Ultrastructure of Adenocarcinoma of the Colon
Journal: JAMA (1963)

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Phase I Study of Anti-Pd-1 Antibody Ono-4538 and Chemotherapy in Patients with Advanced Non-Small-Cell Lung Cancer
Authors: S. Kanda, K. Goto, H. Shiraishi, E. Kubo, A. Tanaka, H. Utsumi, K.S. Sunami, S. Kitazono, H. Mizugaki, H. Horinouchi, Y. Fujiwara, H. Nokihara, N. Yamamoto, T. Tamura
Journal: Annals of Oncology (2014)
The end of excellence.
Journal: BMJ (1976)

number of clinical cases is small, and the illnesses appear relatively mild.Even so, the risk can be reduced.The first aim should be to eliminate the hazard arising from outbreaks, and in Britain control and prevention of the disease have been achieved in haemodialysis units, where the numbers of patient carriers of hepatitis B antigen (HBsAg) have been kept to a minimum'1 and a code of practice has been established.12The background risk to laboratory workers still exists, however, both from patients with hepatitis and (probably more important) from HBsAg carriers with no evidence of hepatitis- at least 0 1 °h ofthe British population.'3Reduction ofinfection from these sources depends on laboratory workers themselves: detailed advice on appropriate precautions is available,'4-16 and the laboratory director should issue clear and compre- hensive instructions that are not too difficult for staff to put into routine practice.Two points are worth emphasising.All specimens-not only those labelled "high risk"-should be considered potentially infective; and staff must report all accidents to allow the potential danger to be assessed and the indications for prophylaxis to be considered.Human normal immunoglobulin protects against hepatitis A.'7 Trials in the USA of immunoglobulin with high titre antibody to HBsAg have shown good, though incomplete, protection.1819Supplies of both materials are held by the Public Health Laboratory Service.
Intrafamilial transmission of hepatitis-C virus among the population of an endemic area of Japan
Authors: K. Nakashima
Journal: JAMA (1995)

<h3>Objectives.</h3> —To assess the role of intrafamilial transmission of hepatitis C virus (HCV) among general populations. <h3>Design and Setting.</h3> —Cross-sectional study in an HCV-endemic area of Japan. <h3>Participants.</h3> —A total of 1122 residents (mean age, 41.7 years; range, 0 to 80 years), including 359 mother-child pairs and 234 pairs of spouses. <h3>Main Outcome Measures.</h3> —Antibody to HCV (anti-HCV) was examined using second-generation anti-HCV testing by passive hemagglutination assay. Hepatitis C virus RNA was detected by polymerase chain reaction with primers deduced from the 5′-noncoding region and HCV genotypes by reaction with type-specific primers deduced from the<i>HCV</i>core gene. <h3>Results.</h3> —Prevalence of anti-HCV was 14.1% (158/1122), and HCV RNA was detected in 82.9% of those who tested positive for anti-HCV. Prevalence of anti-HCV increased with advancing age, but no anti-HCV was found among 312 persons younger than 20 years. Of the 53 children with anti-HCV—positive mothers, three were positive for anti-HCV, all were older than 20 years, and all had a history of surgical treatment. Hepatitis C virus RNA was found in one mother-child pair but with different HCV genotypes. Both spouses were positive for anti-HCV in 17 of 234 pairs. Of the 11 pairs of spouses in whom the HCV genotypes of both were determined, five had different HCV genotypes. <h3>Conclusions.</h3> —While HCV is highly endemic in this area, neither vertical nor horizontal transmission between spouses seems to play an important role in its spread. The incidence of intrafamilial transmission of HCV seems to be low. (<i>JAMA</i>. 1995;274:1459-1461)
Listeria sepsis and meningitis: A complication of renal transplantation
Authors: O. A. Isiadinso
Journal: JAMA (1975)

<i>Listeria</i>infection is an important cause of sepsis and meningitis in renal transplant patients. Prompt recognition and aggressive therapy are required to control this life-threatening infection. In 1972, one case of listeriosis occurred in a renal transplant recipient in our center; in 1974, six more cases were detected within a period of nine months. All seven patients had<i>Listeria</i>sepsis, and three of the seven patients had both sepsis and meningitis. Antibiotic treatment resulted in remarkable improvement in the clinical state of all the patients in this study. Two patients later died of other unrelated causes. (<i>JAMA</i>234:842-843, 1975)
Medical News
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ONE ILLUSTRATION OF FRATERNITY AND CO-OPERATION.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Free Papers
Authors: Luo Ping Sheng, Zi Wen Liu, Bao Hen Liang, Jia Hong Zhong, B. Oldörp, A. M. Schilling, J. Lippmann, R. Öhring, J. Heidenreich, E. Kiem, K. Hennig, C. Michel, T. Neumann, C. Brodel, P. Heidt, W. Schaffartzik, C. Spies, E. Lannoo, C. De Deyne, F. Colardyn, S. Adam, M. Ragaller, J. Hampl, S. A. May, G. Schackert, D. M. Albrecht, J. M. Nava, M. Alyarez, S. Quintana, J. Martinez Pérez, F. Jara, I. Cherta, M. Garcia-Bach, J. L. Maestro de Leon, F. Vila, C. Vivenza, L. Cristofori, R. Gambin, A. Bricolo, G. Salvi, G. Rigoli, R. Avesani
Journal: Intensive Care Medicine (1996)
BOLIVIAN MEDICINE
Journal: JAMA (1960)

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Hepatic function in acute myocardial infarction
Authors: G. Das
Journal: JAMA (1974)

Hepatic function was evaluated in 17 patients with acute myocardial infarction by measuring sulfobromophthalein retention, serum glutamic pyruvic transaminase level, lactic dehydrogenase (LDH ) hepatic isoenzyme, serum bilirubin value, and urinary urobilinogen excretion. Statistically significant alterations in the hepatic function were observed during the acute stage of the infarct as compared to the period following recovery. Hemodynamic changes in patients with acute myocardial infarction may play an important role in the genesis of altered hepatic function. (<i>JAMA</i>230:1558-1560, 1974)
Cardiovascular Research, London
Journal: JAMA (1967)

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THE INSANITARY FLAT.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Metabolism of Cadmium, Zinc and Copper in the Rat Kidney: The Role of Metallothionein and Other Binding Sites
Authors: David H. Petering, Jay Loftsgaarden, Jeffrey Schneider, Bruce Fowler
Journal: Environmental Health Perspectives (1984)

Studies were undertaken to determine the effect of host zinc deficiency upon the distribution of Cd, Zn and Cu between and within male rat kidney cytosol and unfractionated cell pellet. In the first experiment male rates were fed stock diets supplemented with 100 micrograms Cd/mL in the drinking water for 30 days. Then Cd-treated rats and controls were segregated into groups, which received semipurified diets adequate or deficient in zinc for 14 days. After this regimen there were comparable concentrations of total Cd and metallothionein bound Cd in cytosol and the supernatant of sonicated, unfractionated pellet on a microgram Cd/g protein basis. Although less than 5% of cytosolic Cd is not bound to metallothionein (MT), 3-5 times as much non-MT Cd is present in the particulate fraction. The zinc-deficient (Zn-) dietary regime increases the non-MT Cd in the pellet. Quantitations were done of the Cu and Zn distribution in high molecular weight, superoxide dismutase, and metallothionein regions of the profiles of metals from Sephadex G-75 chromatography. In animals exposed to Cd and fed a zinc-normal (Zn+) diet, supernatant and pellet metal contents only change in the MT fraction. Similarly, zinc deficiency affects primarily the complement of metals bound to metallothionein: zinc is markedly decreased and Cu is lowered to a smaller extent. Cadmium is unchanged. Control kidney, unexposed to Cd, normally contains a substantial amount of Zn,CuMT. Two-week zinc deficiency greatly reduces MT-Zn and -Cu content without altering the metal content of other cellular pools.(ABSTRACT TRUNCATED AT 250 WORDS)
BUENOS AIRES
Journal: JAMA (1941)

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Effective humanitarian aid. Our only hope for intervention in civil war
Authors: J. C. Cobey
Journal: JAMA (1993)

Despite the dissolution of the Soviet Union and other totalitarian regimes, the world has yet to see a "peace dividend." Instead of two superpowers competing for sole possession of the best economic and political system, we now see numerous ethnic groups trying to found nations, define separate identities, and vent long-standing resentments. These seemingly sudden and unprecedented conflicts have centuries-old historical roots.<sup>1</sup> Today, of approximately 130 armed conflicts in the world, 32 have each produced more than 1000 battlefield deaths, the majority occurring within the boundaries of individual countries. Since World War II, the number of civilian deaths has surpassed military fatalities in most wars and conflicts.<sup>2</sup>In Cambodia, for example, half the land mine casualties in 1991 were civilian.<sup>3</sup>The International Human Rights Law Institute of DePaul University, Chicago, Ill, estimates that there have been 140 000 to 150 000 war fatalities in the former Yugoslavia
BUENOS AIRES
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 4680: KRAS activation in gastric adenocarcinoma stimulates epithelial-to-mesenchymal transition to cancer stem-like cells and promotes metastasis
Authors: Changhwan Yoon, Jacob Till, Soo-Jeong Cho, Kevin Chang, Jian-Xian Lin, Sandra Ryeom, Sam Yoon
Journal: Cancer Research (2019)

Abstract BACKGROUND: Our previous work showed that in a mouse model of gastric adenocarcinoma (GA) with loss of p53 and Cdh1 that adding oncogenic Kras (a.k.a triple conditional or Tcon mice) accelerates tumorigenesis and metastasis. The Receptor Tyrosine Kinase (RTK)-RAS signaling pathway is altered in 60% of GAs, and KRAS is amplified or mutated in 17% of GAs. There is some evidence that RTK-RAS signaling and oncogenic KRAS are important in the epithelial-to-mesenchymal transition (EMT) and maintenance of cancer stem-like cells (CSCs). We hypothesized that RTK-RAS activation in GA CSCs increases the metastatic potential of these cells. METHODS: The RTK-RAS pathway and KRAS were examined in nontransformed HFE-145 gastric epithelial cells, tumor-derived organoids derived from Tcon mice, human GA cell lines (AGS and KATOIII), AGS xenografts, and a tissue microarray of human GAs from 115 patients undergoing surgical resection. KRAS was inhibited using shRNA, and the RTK-RAS pathway was blocked using a MEK inhibitor PD0325901. RESULTS: Kras activity was much higher in GA cell lines grown as spheroids compared to GA cell lines grown monolayers. Metastasis following KRAS activation in GA cells results from stimulation of epithelial-to-mesenchymal transition (EMT) to cancer stem-like cells (CSCs). In organoids derived from our mouse model, Kras knockdown decreased spheroid formation, expression of EMT-related proteins, migration, and invasion; similar effects, as well as reversal of chemoresistance, were observed following KRAS knockdown in patient tumor-derived GA cell lines. KRAS inhibition in GA spheroid cells led to reduced flank xenograft growth, loss of the infiltrative tumor border, fewer lung metastases, and increased survival. Supporting clinical relevance, high tumor levels of CD44 (a marker of CSCs) and KRAS activation were independent predictors of worse overall survival in 115 GA patients. CONCLUSION: In this study, we show that the addition of oncogenic KRAS into gastric epithelial cells leads to EMT and acquisition of CSC phenotypes. Inhibition of KRAS in GA cell lines and in tumor derived organoids reverses EMT and inhibit CSC phenotypes. We conclude that metastasis following KRAS activation in GA cells likely results from stimulation of EMT and transition to CSCs. Citation Format: Changhwan Yoon, Jacob Till, Soo-Jeong Cho, Kevin Chang, Jian-Xian Lin, Sandra Ryeom, Sam Yoon. KRAS activation in gastric adenocarcinoma stimulates epithelial-to-mesenchymal transition to cancer stem-like cells and promotes metastasis [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4680.