tbuckley/cabot-search huggingface dataset:
Central Neurotransmitter Function and Its Behavioral Correlates in Man
Authors: Israel Hanin
Journal: Environmental Health Perspectives (1978)

The past decade has witnessed a tremendous increase in knowledge towards understanding the function of various brain neurotransmitter substances in behavior. Experimental observations in animals, utilizing specific pharmacological agents, have enabled the development of certain hypotheses regarding neurochemical substrates of behavior. These have led to cautious applications of complementary studies in humans. As a result, several neurotransmitter-related hypotheses have been developed for the explanation of normal behaviour, as well as of various abnormal behavior states in psychiatry and neurology. These hypotheses are currently undergoing extensive investigation. Highlights of the above sequence of events are presented, in order to provide as general, yet extensive, an overview of the subject as possible. Examples are provided from both basic laboratory investigations and from clinical findings. Principles of brain neurotransmitter function and interactions are reviewed. Various neurotransmitter-related hypothese of psychiatric and neurologic interest are introduced. Finally, the role that toxicants may have on behavior via alteration of brain neurotransmitter function is discussed, using the lead intoxicated animals as an illustrative example.
Overinvestigation.
Authors: E. Wilson
Journal: BMJ (1969)

JoxruOkidney is potentially dangerous, since the method of sterilization with 2% fornalin does not reach any reasonable bacterial standard.The tendency of life today is to move towards the use of dis- posable equipment, and the Kfil is really oldfashioned and clumsy.We have had over a year's experience now with the Lucas monitor/dialysate proportion- ing system and been very pleased with its operation, granting, of course, that the machine is well and properly understood.Recently we have also been very pleased with the performance of the Baxter "Ultraflo " coil used in the newest model of the Travenol R.S.P. machine, and it seemed obvious to marry the two together.Thus we have built a container capable of holding the " Ultraflo" coil, providing a continuous flow of dialysate through the coil at high rates of flow and under an adjustable negative pressure so as -to make use of the Lucas monitor system.This prototype canister, made of Perspex, is functioning well, producing perfectly normal dialyses with good end biochemical figures, and achieving these results within a period of between six and eight hours.
Encore
Authors: None Gemaennes
Journal: Annals of the Rheumatic Diseases (1989)

Kkebsiella pneumoniae, HLA-B27, and ankylosing spondylitis Many groups have looked long and hard at cross reactivity between various organisms, particularly klebsiella, and the HLA-B27 antigen.The results of various studies have given rise to debate: enthusiasm by some and scepticism by others.This study showed that all the HLA-B27 positive patients studied who had synovial inflammation showed cross reactivity between HLA-B27. 1 and klebsiella nitrogenase epitopes.They suggested that the putative cross reactive epitope forms part of the HLA-B27 molecule itself.
Manuscripts Approved for JNCI During November–December 1975
Journal: JNCI Journal of the National Cancer Institute (1976)

Journal Article Manuscripts Approved for JNCI During November–December 1975 Get access JNCI: Journal of the National Cancer Institute, Volume 56, Issue 1, January 1976, Pages 202–204, https://doi.org/10.1093/jnci/56.1.202-a Published: 01 January 1976
Erratum
Journal: BMJ (1926)

MuDzCL:II Agents' Fees.UMaL.." recently held a six months' assistantship.He has been assessed for those earnings, but the -inspector refuses to allow a deduction for the fee charged by the agenit through whom be took up.the pos.t.* * * If" McI." habitually takes up temporary assistantships- we consider that he has grounds on
JAMA Reference Directories
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tumour Treating Fields (TTFields) have anti-proliferative effects on paediatric brain tumour cell lines at clinically deliverable field settings
Authors: Joshua Branter, Maria de los Angeles Estevez-Cebrero, Richard Grundy, Surajit Basu, Stuart Smith
Journal: Neuro-Oncology (2018)

Approximately 400 children in the UK are diagnosed with a CNS tumour each, which represents a quarter of childhood cancer cases in the UK. The overall 5-year survival rate of peadiatric brain tumour patients is roughly 75%, however survival still remains poor for some brain tumours, particularly high grade gliomas. Pre-clinical studies have shown efficacy of TTFields on high grade glioma cell lines, while TTFields have only been approved for adult Glioblastoma multiforme (GBM) patients in combination with the Stupp treatment protocol. The lack of overlapping toxicities associated with OptuneTM has made TTFields an attractive treatment strategy for poor prognosis brain tumours. The InovitroTM system is the laboratory testing system used to develop the clinically approved Optune system. InovitroTM was used to deliver TTFields over 72 hours at a range of clinically relevant frequencies (100-400kHz) and intensities (1-3V/cm) to a panel of paediatric GBM, Medulloblastoma and Ependymoma cell lines. The effects of TTFields on cell viability and cell cycle was assessed using metabolic viability tests (Presto blue), cell proliferation assays and cell cycle analysis using flow cytometry. TTFields treatment reduces cell viability of all paediatric brain tumour cell lines tested within the frequency titration. The optimum frequencies were between 200 and 300kHz for all cell lines tested. TTFields treatment had significant effects on cell cycling relative to control cells. This preliminary study has confirmed the efficacy of electric fields on paediatric brain tumour cell lines. The optimum frequencies for the paediatric GBM cell lines did not uniformly fall into the 200kHz range as previously reported for glioma cell lines. This report warrants further study into the potential for TTFields therapy for paediatric patients.
Baseline Cea Serum Levels Predict the Efficacy of Bevacizumab-Based Treatment in Advanced Colorectal Cancer
Authors: J Godinho Bexiga, F Carneiro, D Marques, N Sousa, A Raimundo, M Machado, P Ferreira, C Faustino, M Fragoso, D Erdem, I Yücel, B Yilmaz, G Demirag, E Kut, F Cilingir, Y Kemal, F Teker
Journal: Annals of Oncology (2012)
Abstract 2218: Exosomal PD-L1 and T lymphocyte status predict the effect of anti-PD-1 therapy
Authors: Xiujuan Qu, Chaoxu Zhang, Yibo Fan, Xiaofang Che, Yunpeng Liu
Journal: Cancer Research (2019)

Abstract Background: Anti-PD-1 therapy is approved to be remarkable for cancer treatment. However, the response rate is dissatisfactory. PD-L1 expression in tumor tissue, which affected by chemotherapy, radiotherapy and activity of signal transduction pathways, is unreliable to predict treatment response. Recent studies suggest that exosomal PD-L1 not only exerts immunosuppressive effects besides tumors, but also plays a significant role in development of tumor microenvironment in the distance. A deeper research of exosomal PD-L1 assessment is needed to improve the predictive value and treatment efficacy. Method: We enrolled 28 patients with advanced tumor, including 8 lung adenocarcinoma, 7 lung squamous carcinoma, 4 esophageal carcinoma, 2 colorectal carcinoma, 2 cholangiocarcinoma, 1 small cell lung cancer, 1 gastric carcinoma, 1 duodenal adenocarcinoma, 1 nasopharyngeal carcinoma and 1 tongue squamous cell carcinoma, who were treated by anti-PD-1 therapy followed the standard regimens. Exosomes were collected and purified from plasma with exosome isolation kit. Exsomal PD-L1 was detected by ELISA. Peripheral blood mononuclear cells (PBMCs) were isolated using Ficoll gradient. Exhausted T lymphocyte were stained for cytometry. Result: Compared with responder, exosomal PD-L1 of non-responders is significantly higher than responder (P=0.036) before treatment. Moreover, the CD4+ and CD8+ T lymphocyte count is higher and the percentage of exhausted T lymphocyte rate is lower in responder than the non-responder cohort before treatment. Although there is no statistical difference, the level of exosomal PD-L1 decreased in responder cohortat on 6 to 8 weeks after treatment, on the contrary, increased in non-responder cohort after anti-PD-1 therapy. Concurrently, exosomal PD-L1 and tumor burden were decreased when the therapy was effective. Conclusion: Low levels of exosomal PD-L1 and exhausted T lymphocyte rate on baseline and decreasing expression of exosomal PD-L1 after treatment could screen out the potential benefit populations of anti-PD-1 therapy in a variety of solid tumors. These findings suggest that expression of exosomal PD-L1 and exhausted T lymphocyte cell rate could be attractive and predictive biomarkers for clinical responses to anti-PD-1 treatment. Note: This abstract was not presented at the meeting. Citation Format: Xiujuan Qu, Chaoxu Zhang, Yibo Fan, Xiaofang Che, Yunpeng Liu. Exosomal PD-L1 and T lymphocyte status predict the effect of anti-PD-1 therapy [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2218.
Impact of cataract surgery with lens implantation on vision and physical function in elderly patients
Authors: W. B. Applegate
Journal: JAMA (1987)

We conducted a prospective study of 293 elderly patients undergoing cataract surgery with intraocular lens implantation to determine the impact of the surgery on vision and on subjective and objective measures of patient function. Visual acuity in the surgical eye improved from a mean of 20/100 before surgery to 20/40 four months after surgery; improvement was maintained at one year. Positive changes occurred in some subjective measures of patient function, such as reported activities of daily living and patient report of vision-dependent activities, but these changes were modest. The most marked changes in patient function occurred in objective measures of function. Mental status had improved not quite significantly at four months but significantly at one year. Timed manual performance improved dramatically and significantly at four months and one year. Cataract surgery was associated with improved vision and improved objective function in most patients by four months after surgery, and these improvements were maintained at one year. (<i>JAMA</i>1987;257:1064-1066)
Clinical aspects of eosinophilia in atopic disease
Authors: F. C. Lowell
Journal: JAMA (1967)

There is a striking relationship between eosinophilia and allergenic exposure among atopic patients, and the existence of eosinophilia is an indication of such exposure. The term "eosinophilosis" is suggested as an appropriate descriptive designation embracing all patients with atopic manifestations whether or not specific allergic causes are recognizable. There are many advantages to the total eosinophil count (TEC) in diagnosis and in the assessment of response to treatment with steroids.
All you need to read in the other general journals
Journal: BMJ (2009)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following All you need to read in the other general journals Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
How Would You Decide?
Journal: JAMA (1974)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ON BICYCLING FOR WOMEN.
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Why Estimates of Physician Supply and Requirements Disagree
Authors: Elizabeth C. Feil
Journal: JAMA (1993)

<h3>Objective.</h3> —To review the major forecasts of physician supply and physician requirements. <h3>Data Sources.</h3> —English-language medical literature on physician manpower published between 1980 and 1990, identified from journal articles selected through searches of the MEDLINE and Health Planning and Administration databases using the search formulations<i>physician supply, health manpower— physicians, and physician manpower</i>. <h3>Study Selection.</h3> —Sources were selected if they were repeatedly cited and provided quantitative projections. <h3>Data Extraction.</h3> —Each study was reviewed for its quantitative projections and to identify its methodological assumptions. <h3>Data Synthesis.</h3> —All forecasts point to a steadily increasing physician supply and, with one exception, suggest that supply will exceed requirements in the year 2000. The estimates of physician supply across studies varied primarily because of differing assumptions about entrance rates into the profession and the size and clinical work load of specific categories of physicians: researchers, teachers, administrators, residents, and women. The estimates of physician requirements were more volatile because of differences in the basic approach and assumptions about future growth and market structure. <h3>Conclusions.</h3> —Even though the measurement of entrance and exit rates from the profession is a generally accepted approach to forecasting supply, apparently minor disagreements on assumptions create large discrepancies between forecasts over time. There is no accepted approach to forecasting physician requirements. (<i>JAMA</i>. 1993;269:2659-2663)
Intermittent claudication with pedal pulses
Authors: H. B. Barner
Journal: JAMA (1968)

Intermittent claudication occurred in 16 patients (22 legs) despite the presence of a pedal pulse at rest. Exercise, by walking or toe-stands, sufficient to induce claudication resulted in disappearance of the pedal pulse until the claudication subsided (one to three minutes) when the pulse was again palpable. Blood pressure at the ankle normally declines with exercise due to dilatation of the muscular vascular bed. Proximal occlusive disease results in a profound fall in distal blood pressure with concomitant loss of the pedal pulse. There was atherosclerotic occlusive disease at the aorto-iliac level in nine legs and at the femoro-popliteal level in nine legs. Traumatic or congenital arterial disease occurred in four legs. There were persistent pedal pulses after arterial reconstruction in 19 legs, and three have not been treated. Claudication in the presence of resting pedal pulses is usually associated with major artery disease that is amenable to reconstruction.
Randomized multicenter phase III trial comparing two neoadjuvant chemoradiotherapy (CT-RT) regimens (RT45-Cap versus RT50-Capox) in patients (pts) with locally advanced rectal cancer (LARC): Results of the ACCORD 12/0405 PRODIGE 2
Authors: J. Gerard, D. Azria, S. Gourgou-Bourgade, I. Martel-Laffay, C. Hennequin, P. Etienne, V. Vendrely, T. Conroy, E. Francois, C. Montoto-Grillot
Journal: Journal of Clinical Oncology (2009)

LBA4007 Background: Following the results of randomized trials FFCD 9203 and EORTC 2291, neoadjuvant CT-RT is considered standard treatment for LARC. The ACCORD 12/0405 PRODIGE 2 trial was initiated to optimize this regimen. Methods: Pts with T3 or resectable T4 N0–1-2 M0, rectal adenocarcinoma were randomized to arm A: concurrent RT 45Gy/25f/5 weeks (w) + capecitabine (800mg/m2/bid) or arm B: concurrent RT 50Gy/25f/5w + capecitabine (800mg/m2/bid/5/7days) + oxaliplatine 50mg/m2/w. Resection with Total Mesorectum Excision was scheduled 6 weeks after the end of CT-RT. Adjuvant chemotherapy was optional. 590 patients were needed to show an increase in the pathological complete response (Dworak) rate from 11% (arm A) to 20% (arm B). Circumferential positive rectal margin (CRM R1) was defined as the presence of residual cancer cells within 0 to 1 mm from the perirectal surface. Results: This trial closed in 07/2008 after randomization of 598 pts since 11/2005. Patients characteristics of 586 eligible pts were well balanced: male 66%, median age 61 years, 66% low rectum, 87% T3 stage. Data base was locked in March 2009. Results are reported in Table. Conclusions: The RT 50 capox regimen is compatible with surgery in 98% of cases with no increase in postoperative complication. In the RT 50 arm, there is a trend in favour of a higher rate of pathological complete sterilization and lower rate of positive CRM. These data could contribute to design a new standard preoperative regimen for LARC. 50 Gy/25 F/5 weeks combined with concurrent chemotherapy could be proposed as an efficient schedule. Eligible patients Arm A RT 45-Cap (295) Arm B RT 50-Capox (291) Preop Grade 3/4 all toxicity 32 (11%) 73 (25%) p: < 0.001 Surgery performed 289 (98%) 287 (98.6%) Sphincter saving surgery 218 (75%) 223 (78%) Postop death (60 days) 1 (0.3%) 1 (0.3%) yp M1 (abdomen) 12 (4%) 8 (2.8%) CRM R1 18 (11%) 9 (6%) p: 0.12 yp CR (Dworak) 40 (13.8%) 54 (18.8%) p: 0.11 No significant financial relationships to disclose.
AMAGRAMS
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Subacute constrictive uremic pericarditis. Survival after pericardiectomy
Authors: V. K. Pillay
Journal: JAMA (1976)

Uremic pericarditis progressed to subacute constriction despite intensive medical treatment in two patients with concomitant metabolic stress of surgery and infection. Total pericardiectomy was successful and should be done as soon as medical measures fail to resolve the pericarditis. (<i>JAMA</i>235:1351-1352, 1976)
Veterinary Oncology
Authors: T. Smith
Journal: JNCI Journal of the National Cancer Institute (1990)

Journal Article Veterinary Oncology Get access Tom Smith Tom Smith John N. Dalton Oncology Clinic Medical College of Virginia Virginia Commonwealth UniversityBox 37-MCV Station Richmond, VA 23298–0037 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 82, Issue 4, 21 February 1990, Page 327, https://doi.org/10.1093/jnci/82.4.327 Published: 21 February 1990