tbuckley/cabot-search huggingface dataset:
Report of Three-Year Study of Red Cell Mobility and the Slowing Factor in Serum of Persons with Lymphoma
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ON THE MANAGEMENT OF FEVERS IN CHILDREN...
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 1495: Existence of Hyperfiltration in an Early Diabetic Rat was Visualised by Multiphoton Microscopy
Authors: Hiroshi Nakamoto, Yasuo Ogasawara, Fumihiko Kajiya
Journal: Circulation (2008)

To visualise glomerular filtration under physiological conditions in an early diabetic rat and to evaluate filtration molecularly and quantitatively. We used 4 week STZ (50 mg/kg) model as early diabetic rats. We measured diameters of afferent (aff) and efferent (eff) arterioles, glomerular red blood cell velocities and left renal blood flow with our intravital videomicro-scope. Glomerular filtration was visualised by multiphoton microscopy. Various sizes of dextran (3k, 10k, 40k and 70k dalton (Dal)) conjugated with Texas Red in 0.5 ml were administered intravenously by bolus shot and for the next 60 seconds glomerular filtration was observed. FITC conjugated 500k Dal dextran was administered to dye intravascular area. The time course of Texas Red intensity in Bowman’s space was measured from the recorded images. Intensity peak values were normalized by the peak value of 3k Dal as sieving coefficients since the intensity reached its peak within 10 seconds after administration of Texas Red conjugated dextrans. Afferent arteriolar diameters were larger than efferent arteriolar diameters in both control (n=6) and diabetic (n=7) rats. Increases of both afferent and efferent diameters were remarkable in diabetic rats (p&lt;0.05) (aff/eff diameter, DM rats: 14.0 ± 1.9, 9.4 ± 0.7, Control rats: 11.9 ± 0.8, 8.8 ± 0.7 μm). Glomerular red blood cell velocity in diabetic rats was larger than that in control rats (p&lt;0.05) (DM/Control rats: 0.236 ± 0.030, 0.196 ± 0.076 mm/s). Left renal blood flow in diabetic rats was larger than that in control rats (p&lt;0.05) (DM/Control rats: 1.84 ± 0.16, 1.60 ± 0.17 ml/100 gBW). All of these findings suggest the existence of hyperfiltration in early diabetic rats. In fact, filtration of the larger dextrans (40k and 70k Dal) were clearly visualized by multiphoton microscopy in early diabetic rats indicating greater leakage even from the early stage of diabetes with a significant difference by about 20% for the 40k and 70k Dal sieving coefficients comparing with the control group (p&lt;0.05). Both afferent and efferent arteriolar diameters were increased in early diabetic rats suggesting the existence of hyperfiltration and the hyperfiltration was clearly visualised by multiphoton microscopy.
A pilot study of preoperative (Pre-op), single-dose ipilimumab (Ipi) and/or cryoablation (Cryo) in women (pts) with early-stage/resectable breast cancer (ESBC).
Authors: Adi Diab, Stephen Barnett Solomon, Christopher Comstock, Majid Maybody, Virgilio Sacchini, Jeremy C. Durack, Brian Blum, Jianda Yuan, Sujata Patil, Deirdre A. Neville, Janice S. Sung, Alan Kotin, Elizabeth Ann Morris, Edi Brogi, Monica Morrow, Jedd D. Wolchok, James Allison, Clifford Hudis, Larry Norton, Heather L. McArthur
Journal: Journal of Clinical Oncology (2013)

67 Background: Intratumoral cryo combined with immune modulation generates a potent systemic anti-tumor immune response that might improve recurrence free survival in ESBC. In this study, we evaluate the safety of pre-op cryo and/or ipi (10mg/kg) in pts with ESBC. Radiographic correlates and intratumoral/serologic immune responses are also explored. Methods: Eligible pts are ≥18y of age with operable ≥1.5 cm invasive ESBC, no history of autoimmune disease and planned mastectomy. Pts are sequentially assigned to receive pre-op: cryo alone (Group-A), ipi alone (B), or ipi with cryo (C). Cryo is administered 7-10d prior to surgery. Ipi is administered 8-15d prior to surgery (1-5d prior to cryo). If at least 5/6 pts in each group proceed with surgery without delay, the regimen will be considered safe/tolerable. Toxicity evaluation continues for 12 wks after ipi administration for Groups B and C. Results: As of May 1, 2013, 7/7 pts were enrolled to Group-A (expanded after a possible technical failure in 1 pt) and 6/6 pts were enrolled to Group-B. The median age was 45y (range 39-69y). All 13 pts in Groups A and B underwent mastectomy without delay. Group C is now accruing with 1/6 patients enrolled and awaiting surgery. 6/7 pts in Group-A and none in Group-B had ischemic tumor necrosis/infarction in the mastectomy tissue. Overall, pre-op cryo or ipi alone have been well tolerated with no study related grade 3/4 adverse events (AE) reported (Table). Conclusions: To date, pre-op cryo or ipi is safe and tolerable in pts with ESBC. A Phase II study of pre-op ipi and cryo in ESBC is planned. Clinical trial information: NCT01502592. [Table: see text]
Figure Key Error
Authors: Gregory Nadolski, Christina Jacovides, Jose Pascual, Carlo Rosati, Thomas Peters
Journal: JAMA Surgery (2016)

Cecilia G. Ethun, MD; Lauren M. Postlewait, MD; Nina Le, BS; Timothy M. Pawlik, MD, MPH, PhD; Stefan Buettner, MD; George Poultsides, MD; Thuy Tran, MD; Kamran Idrees, MD; Chelsea A. Isom, MD; Ryan C. Fields, MD; Linda X. Jin, MD; Sharon M. Weber, MD; Ahmed Salem, MD; Robert C. G. Martin, MD, PhD; Charles Scoggins, MD; Perry Shen, MD; Harveshp D. Mogal, MD; Carl Schmidt, MD; Eliza Beal, MD; Ioannis Hatzaras, MD; Rivfka Shenoy, MD; David A. Kooby, MD; Shishir K. Maithel, MD
Robert Bárány
Authors: Nicholas Torok
Journal: JAMA (1980)

<h3>To the Editor.—</h3> Referring to the remarks in the philatelic column (243:1914, 1980), the relatively short life of Robert Bárány was abound with inventions, discoveries, and groundwork that eventually became known as neurotology. At the same time there were intrigues and controversies that often have been the fate of innovators. It is not possible to condense a colorful life story in a few sentences available in the column assigned to medical stamps, but several errors in the short description by Shampo and Kyle require some correction. The principal teacher of Bárány was Adam Politzer, indeed, who was the head of the Otology Clinic in Vienna and not of Ophthalmology. When Bárány received the Nobel Prize he was a prisoner of war in Siberia and was freed by the intervention of the king of Sweden. He was offered subsequently the headship of the newly established Ear, Nose, and Throat Clinic at
Interferon Inhibitors
Authors: J. L. Ambrus, K. C. Chadha, J. L. Ambrus
Journal: Annals of Internal Medicine (1991)

Letters1 April 1991Interferon InhibitorsJ. L. Ambrus, MD, PhD, K. C. Chadha, PhD, J. L. Ambrus Jr., MDJ. L. Ambrus, MD, PhDSearch for more papers by this author, K. C. Chadha, PhDSearch for more papers by this author, J. L. Ambrus Jr., MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-114-7-606_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: In previous reports, we described nonantibody-type interferon inhibitors in patients with systemic lupus erythematosus (1). We are in the process of isolating and identifying these inhibitors and of studying their mechanisms of action. Similar inhibitors were found in the circulation in patients with some neoplastic and viral diseases including the acquired immunodeficiency syndrome (AIDS) (2-4). These inhibitors were not found in normal persons.We have recently studied a patient with advanced, biopsy-proved Wegner granulomatosis and vasculitis. Using previously reported methods to assay interferon inhibitory activity (3, 4), we found that this patient had 35 Roswell Park Memorial...References1. AmbrusAmbrusChadha JJK. Interferon inhibitors in lupus erythematosus. N Engl J Med. 1988;319:582-3. CrossrefMedlineGoogle Scholar2. AmbrusChadhaHalpernKhalilPiverHreshchyshyn JKJMMM. The interferon system in gynecologic cancer: effect of radiation and chemotherapy. Cancer. 1991 [In press]. MedlineGoogle Scholar3. AmbrusPoieszLillieStadlerDi BerardinoChadha JBMSLK. Interferon and interferon inhibitor level in patients infected with varicella-zoster virus, AIDS, ARC, Kaposi's sarcoma and in normal individuals. Am J Med. 1989;87:405-7. CrossrefMedlineGoogle Scholar4. ChadhaAmbrusIkossi KJM. Interferons and interferon inactivators in AIDS, ARC and in cancer patients. In: The Biology of the Interferon System 1986. Cantell K, Schellekens H, eds. Martinus Nizhoff; 1987:783. Google Scholar5. ChadhaAmbrusStadlerAmbrus KJIJ. Interferon inhibitor in the blood of patients with systemic lupus erythematosus. J Biol Regul Homeost Agents. 1991;4:22-30. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Washington University St. Louis, MO 63110 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByInterferons and Interferon Inhibitory Activity in Disease and TherapyFree interferon-?/? receptors in the circulation of patients with adenocarcinomaDifferential effects of human immunodeficiency virus type 1 envelope protein gp120 on interferon production by mononuclear cells from adults and neonates 1 April 1991Volume 114, Issue 7Page: 606-607KeywordsAIDSInterferonsLupus erythematosusVasculitisViral diseases Issue Published: 1 April 1991 PDF DownloadLoading ...
Helmets for motor cyclists: lower fatal head injury rate but more crashes mean more study
Authors: C. Desoer
Journal: JAMA (1992)

<h3>To the Editor.</h3> —I read with interest the data presented by Sosin and Sacks<sup>1</sup>regarding motorcycle helmet-use laws. I found the data particularly interesting in that the lower rate of death due to head injury was countered by a higher crash rate, resulting in comparable overall death rates. The authors suggest, but in no way demonstrate, that the higher crash rate "may reflect riskier conditions, riskier behaviors, or differences in crash reporting." There do not appear to be adequate data to exclude the increased helmet use itself as a possible cause of the increased crash rate. Notwithstanding the studies cited by Sosin and Sacks, decreased sensory input or other mechanisms not yet studied might be implicated in the increased crash rate. I feel that further study into this question is needed. Until such time as the increased crash rate and the lack of improvement in overall mortality can be
Physician supply: primary catalyst of change
Authors: J. A. McMahon
Journal: JAMA (1986)

The Medicare prospective pricing system's dramatic entry into the health care scene 31/2 years ago has led many people to view it as the watershed event in health care delivery of this decade. Granted, the new system has wrought major changes and the attention it is getting is not altogether undeserved. However, the diagnosis related groups (DRG) system is only number 3 on my list of change agents. As prospective pricing went into effect, there were other more important changes already occurring in the health care environment. The increase in the number of physicians in the United States, in my opinion, has had the most far-reaching impact on the health care world. Over the course of the past 15 years, the number of practicing physicians increased by 60%. For the first time, physicians began competing for patients, working as salaried employees, and going into some of the new alternative delivery
Intestinal obstruction in survivors of childhood cancer: A report from the Childhood Cancer Survivor Study (CCSS).
Authors: Arin L Madenci, Stacey Fisher, Lisa Diller, Robert E. Goldsby, Wendy M. Leisenring, Kevin C. Oeffinger, Leslie L. Robison, Charles A. Sklar, Marilyn Stovall, Rita Weathers, Gregory T. Armstrong, Yutaka Yasui, Christopher Bertero Weldon
Journal: Journal of Clinical Oncology (2015)

10071 Background: For adult survivors of childhood cancer, knowledge about the long-term risk of intestinal obstruction from surgery, chemotherapy, and radiotherapy is limited. Methods: Intestinal obstruction requiring surgery (IOS) occurring 5 or more years after cancer diagnosis was evaluated in 12,316 five-year survivors from the CCSS cohort (2,002 with and 10,314 without abdominopelvic tumors) and 4,023 sibling participants. Cumulative incidence of IOS was calculated with second malignant neoplasm, late recurrence, and death as competing risks. Piecewise-exponential models assessed the associations of clinical and demographic factors with rate of IOS. Results: IOS was reported by 165 survivors (median age at IOS=19 years, range=5-50 years; median time from diagnosis to IOS=13 years) and 14 siblings. Cumulative incidence of IOS at 35 years was 5.8% (95% confidence interval [CI]=4.4-7.3%) among survivors with primary abdominopelvic tumors, 1.0% (95% CI=0.7-1.4%) among those without abdominopelvic tumors, and 0.1% (95% CI=0.1-0.5%) among siblings. Survivors of abdominopelvic lymphoma had the highest 35 year cumulative incidence of IOS, 7.2% (95% CI=2.8-12.5%). Among all survivors, abdominopelvic tumor (adjusted rate ratio [ARR]=3.6, 95% CI=1.9-6.8, P<0.001) and abdominal/pelvic radiotherapy within 5 years of diagnosis (ARR=2.4, 95% CI=1.6-3.7, P<0.001) increased the rate of IOS, adjusting for year of diagnosis; sex; race/ethnicity; age at diagnosis; age during follow-up (as natural cubic spline); primary cancer type; and chemotherapy, radiotherapy, and surgery occurring within 5 years of diagnosis. Developing IOS increased the subsequent mortality among survivors (ARR=1.8, 95% CI=1.1-2.9, P=0.016), adjusting for the same clinical and demographic factors. Conclusions: In the decades following diagnosis and treatment, survivors of childhood cancer are at increased risk of developing late-onset IOS, with subsequent increased risk of mortality. These findings underscore the need to promote long-term awareness of these risks among patients and providers, especially for survivors with abdominal or pelvic tumors who have undergone treatment with surgery or radiotherapy.
PP71. CLINICAL OUTCOMES FOR GLIOBLASTOMA PATIENTS WITH SOLITARY, MULTIFOCAL AND MULTICENTRIC DISEASE
Authors: Dr Tareq Abdullah, Dr R N Joseph, Ms Mairi Mackinnon, Ms Aoife Williamson, Dr Stefan Nowicki, Dr Brian Clark, Prof Anthony Chalmers, Dr Allan James
Journal: Neuro-Oncology (2017)

INTRODUCTION: Based on imaging features, glioblastoma (GBM) can be classified as solitary, multifocal or multicentric. The incidence of multifocal/multicentric GBM has been reported to range from 0.5 to 35% and some studies have reported poorer survival in patients with multiple lesions. Two potential reasons have been proposed: (1) intrinsic differences in tumour biology; (2) failure to encompass the entire tumour within the radiotherapy planning tumour volume. To address this question we investigated clinical, imaging and genetic features in a cohort of GBM patients. METHODS: Imaging, clinical, treatment, MGMT methylation and outcome data were collected retrospectively from consecutive GBM patients treated in a single cancer centre between January 2011 and June 2012. Tumours were categorised as solitary, multifocal or multicentric by a consultant neuroradiologist. RESULTS: 122 patents with GBM were identified. Median age was 60 and male:female ratio was 2.1:1. MGMT promoter status was unmethylated in 48% of tumours, methylated in 37% and unknown in 15%. Preoperative imaging modality was CT in 70% and MRI in 30% of patients. Overall, the proportion of patients with solitary, multifocal and multicentric tumours was 78%, 15.5% and 6.5 % respectively, but in patients undergoing MR imaging these proportions were 60%, 26.5% and 13.5%. Gross total resection was performed in 65% of solitary compared with 42% of multifocal and 25% of multicentric cases, and radical chemoradiation was delivered to 50% of solitary, 58% of multifocal and 12% of multicentric cases. Overall, median survival was increased in solitary compared with multifocal/multicentric patients (9.9 vs. 6.7 months, p = 0.046). In patients receiving radical chemoradiation, however, there was no difference in overall survival between solitary and multifocal/multicentric patients (18.5 vs. 16.8 months, p=0.57). MGMT promoter methylation was associated with increased survival in patients with solitary tumours (14.6 vs. 8.5 months, p= 0.014) but not multifocal/multicentric tumours (3.8 vs. 6.9 months, p= 0.3). CONCLUSION: In this retrospective study the incidence of multifocal/multicentric GBM was in line with previous studies. Pre-operative CT imaging may underestimate the incidence of multifocal/multicentric disease. Our main finding was that multifocality or multicentricity did not affect survival in patients to whom radical chemo-radiotherapy could be delivered.
Administration of family practitioner services in reorganised NHS.
Journal: BMJ (1981)

Paragraph 18 of the reorganisation circular HC(80)8' said, "The present arrangements for the administration of family practitioner services will be retained....A further circular will be issued later about the funding and membership of FPCs with a view to strengthening the relationship between them and the DHAs in the planning of services."The DHSS has now issued a consultative document, Arrangements for the administration offamily practitioner services (HN(8 1) 10).This outlines the responsibilities of the new district health authorities (DHAs) and family practi- tioner committees (FPCs) and invites com- ments on options for the future relationship between them and ways in which effective collaboration can be secured.Comments should be submitted by the end of May 1981.The circular, with the exception of the annex setting out the present functions of FPCs, is reproduced here.
Pancreatic Ducts and Postoperative Pancreatitis
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Allied health education and accreditation
Authors: J. J. Fauser
Journal: JAMA (1989)

<h3>SHARED RESPONSIBILITY AND MUTUAL SUPPORT: THE AMA AND ALLIED HEALTH EDUCATION AND ACCREDITATION</h3> For more than 50 years, the American Medical Association (AMA) and its members have recognized the value of actively participating in and promoting quality education for allied health personnel to maintain an adequate supply of qualified professionals whose functions include complementing, facilitating, or assisting in the work of physicians and other health care specialists. <h3>Physician Contributions to the Accreditation Review Process</h3> Physicians promote quality education for allied health professionals by participating in the accreditation review process coordinated by the AMA Committee on Allied Health Education and Accreditation (CAHEA). By serving as teachers and medical directors/advisers in allied health educational programs, as members of review committees, and as site visitors, they make significant contributions to professional standards, to educational programs, to identifying and addressing critical issues, and to the decision-making and consensus-forming process. Through the CAHEA structure, the
Pediatric Surgery
Authors: John G. Raffensperger
Journal: JAMA (1970)

Eighty specialists in various branches of children's surgery have devoted tremendous amounts of time and energy to make the second edition of<i>Pediatric Surgery</i>truly encyclopedic. The authors have rewritten nearly every chapter and have added 31 new sections to reflect the amazing advances in pediatric surgery since the first edition was published. Thoracic, abdominal, and genitourinary surgery, the traditional areas of the pediatric surgeon, are exceptionally comprehensive. The common surgical afflictions, from meatal stenosis to esophageal atresia, are discussed clearly and concisely from the authors' wide experience. Unusual anomalies which a surgeon may encounter only once in a lifetime are equally well described. In addition, the surgical literature is reviewed in depth to provide us with the most extensive existing bibliography of pediatric surgery. The chapters on pulmonary disease, intussusception, and diaphragmatic hernia are outstanding and the history of surgery for appendicitis is a little gem. The basic sciences