tbuckley/cabot-search huggingface dataset:
Optical transfer diagnosis differentiating benign and malignant pigmented lesions in a simulated primary care practice
Authors: D.L. Swanson, R.V. Venneugues, S.Q. Vicencio, J. Garioch, M. Biryulina, G. Ryzhikov, B. Hamre, L. Zhao, F.S. Castellana, K. Stamnes, J.J. Stamnes
Journal: British Journal of Dermatology (2018)

The incidence of the type of skin cancer called melanoma is on the rise. The detection of melanoma can be difficult, particularly for clinicians who have limited training (compared to dermatologists who specialize in skin) in telling the difference between normal moles (nevi) and melanomas. The noninvasive optical transfer diagnosis (OTD) method is a technology designed to assist in the screening of lesions (e.g. moles) that might be melanomas. In this study, from the U.S.A., U.K. and Norway, the authors took images using OTD and then analysed 712 pigmented lesions (which could be moles or melanomas). Of them, 415 were harmless, or ‘benign’, and 297 were suspicious when examined by specialists using a magnifier called a dermatoscope. After image capture, all of the suspicious moles were biopsied and the tissue samples were examined under the miscroscope. Of the suspicious lesions, 80 proved to be cancer on biopsy (64 melanomas, and 16 other types of skin cancer). OTD misdiagnosed 1 of the 80 cancerous lesions as benign. If verified in further studies, particularly in actual primary care settings, it is likely that the use of OTD technology could help doctors reduce the number of referrals to dermatologists, excision (surgical removal of the lesion), or biopsy, and reduce costs. Further studies are planned for screening patients in the primary care (e.g. GP) setting, with comparisons of OTD results to the gold standards of pathology or dermoscopy.
Eating Disorders
Authors: ELKE D. ECKERT
Journal: Annals of Internal Medicine (1987)

Letters and Corrections1 March 1987Eating DisordersELKE D. ECKERT, M.D., JAMES E. MITCHELL, M.D., RICHARD L. PYLE, M.D.ELKE D. ECKERT, M.D.Search for more papers by this author, JAMES E. MITCHELL, M.D.Search for more papers by this author, RICHARD L. PYLE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-106-3-480_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: As specialists in the treatment of eating disorders, we were pleased but also alarmed by the position paper on eating disorders ( 1 ) that was recently published in Annals. We were pleased to see the focus on the need for practicing physicians to recognize the increasing prevalence of anorexia nervosa and bulimia, to learn to identify these disorders, and to be familiar with and screen for the medical complications that may occur.Although the position paper also correctly pointed out that medical management is very important in the treatment of eating disorders, we were surprised at...References1. . Eating disorders: anorexia nervosa and bulimia. Ann Intern Med. 1986;105:790-4. LinkGoogle Scholar2. HUGHESWELLSCUNNINGHAMILSTRUP PLCD. Treating bulimia with desipramine. Arch Gen Psychiatry. 1986;43:182-6. CrossrefMedlineGoogle Scholar3. MITCHELLGROAT JR. A placebo-controlled, double-blind trial of amitriptyline in bulimia. J Clin Psychopharmacol. 1984;4:186-93. CrossrefMedlineGoogle Scholar4. WALSHSTEWARTROOSEGLADISGLASSMAN BJSMA. Treatment of bulimia with phenelzine: a double-blind, placebo-controlled study. Arch Gen Psychiatry. 1984;41:1105-9. CrossrefMedlineGoogle Scholar5. CALLISPOPKIN AM. Antidepressant treatment of medical-surgical inpatients by non-psychiatrist physicians. Arch Gen Psychiatry. (In press). Google Scholar6. MAYOUSMITH RE. Hospital doctors management of psychological problems. Br J Psychiatry. 1986; 148:194-7. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Minnesota School of Medicine Minneapolis, MN 55455 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1987Volume 106, Issue 3Page: 480-481KeywordsAnorexia nervosaEating disorders Issue Published: 1 March 1987 PDF DownloadLoading ...
Renal Effect of Subcommissural Extracts
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Analysis of Breast Milk to Assess Exposure to Chlorinated Contaminants in Kazakstan: High Levels of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) in Agricultural Villages of Southern Kazakstan
Authors: Kim Hooper, Myrto X. Petreas, Tamara Chuvakova, Gulnara Kazbekova, Natalia Druz, Gulnara Seminova, Turgeldy Sharmanov, Douglas Hayward, Jianwen She, Pat Visita, Jennifer Winkler, Michael McKinney, Timothy J. Wade, Jean Grassman, Robert D. Stephens
Journal: Environmental Health Perspectives (1998)
Insurability, Prognosis and Selection. Life, Health, Accident. A Treatise on Various Factors That Permit a Forecast of Health and Longevity, Selection of Risk for Insurance and Appraisal of Claim for Indemnity.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
O07 * CHARACTERISING REGIONAL HETEROGENEITY OF GLIOBLASTOMA USING MULTIMODAL IMAGING: REGIONS OF AGGRESSIVE GROWTH
Authors: N. R. Boonzaier, T. Larkin, V. Lupson, O. Thomas, A. Young, S. J. Price
Journal: Neuro-Oncology (2014)

INTRODUCTION: Glioblastoma multiforme (GBM) is the most aggressive primary brain tumour. Intra-tumour heterogeneity of GBM is a contributing factor to treatment failure and non-invasive methods are needed for analysis. This study aimed to identify imaging signatures of aggressive tumour belonging to different regions of GBM using multimodal imaging methods, including diffusion-weighted imaging and MR spectroscopy. METHOD: 32 Patients (mean age 57.2 years) with confirmed GBM were imaged at 3T on a Siemens Trio. Maps of apparent diffusion coefficient (ADC) were coregistered to T2-weighted images. Regions of interest (ROI) were selected: FLAIR enhancement with T1-weighted post-contrast enhancement (CE); and FLAIR enhancement without CE (FLAIR). Within these regions, an ADC cut-off value was developed using MATLAB. Metabolic maps of Cho/tNAA ratios belonging to these ADC ROIs were calculated using LCModel. Ratios from CE and FLAIR were compared to each other and to ratios of ROIs above the ADC threshold within tumour (high ADC) and normal appearing white matter (NAWM). RESULTS: Ratio values of CE and FLAIR were significantly higher than those of NAWM (0.26 ± 0.09) (0.60 ± 0.21, p < 0.001; 0.45 ± 0.22; p < 0.001 for CE and FLAIR, respectively). ROIs of high ADC had a mean ratio value (0.39± 0.16) that was significantly lower than that of CE (p < 0.01). CONCLUSION: Findings suggest that regional heterogeneity of GBM can be detected and characterised using advanced imaging. Low ADC ROIs within CE regions appear to have metabolic profiles representing aggressive tumour with higher Cho/tNAA ratios. Combining imaging modalities could potentially differentiate regions that will respond/fail to respond to treatment.
Tuberculoma of the brain
Authors: J. A. Damergis
Journal: JAMA (1978)

Four patients with cerebral tuberculomas had presenting manifestations that included seizure disorder, exophthalmos, or extremity weakness. Although rare in this country, this diagnosis should not be overlooked in such patients, since combined surgical and medical therapy may be curative. (<i>JAMA</i>239:413-415, 1978)
Hemodynamic effects of direct-acting antivirals in patients with hepatitis-C virus-associated cirrhosis and portal hypertension non responsive to beta-blockers
Authors: Edilmar Alvarado, Sabela Lens, Alba Ardevol, Marta García Guix, Anna Baiges, Ana Brujats, Laura Gonzalez Gonzalez, Zoe Mariño, Xavier Torras, Adolfo Gallego Moya, Virginia Hernandez-Gea, Xavier Forns, Juan Carlos Garcia Pagan, Candid Villanueva
Journal: Journal of Hepatology (2020)
Urinary copper excretion after penicillamine challenge in children with prolonged hepatitis a infection
Authors: G Gregorio
Journal: Hepatology (1993)

Urinary Copper Excretion After Penicillamine Challenge in Children with ProlongedHepatitis A Infection To the Editor:We have previously reported that urinary copper excretion of more than 25 p.mo1124 hr after penicillamine challenge is the most accurate single diagnostic test for Wilson's disease (WD) in children with liver disease (1).In a study of 75 children, 15 of 17 with WD had urinary copper levels more than 25 p,mo1/24 hr, whereas this feature was observed in only 1 of 58 children with other liver disorders.Other parameters of copper metabolism (ceruloplasmin, serum and liver copper content and baseline 24-hr urinary copper excretion) were less sensitive in differentiating WD from other liver disorders.We would like to report our recent experience in three children (two girls; age 8, 10 and 15 yr) with acute persistent hepatitis A virus (HAV) infection, a group that was not included in the original study.All patients were positive for HAV IgM and had been jaundiced for at least 12 wk, with pruritus, fatigue, anorexia and weight loss before referral to our unit.Their histories and family histories were unremarkable.All were jaundiced, with firm hepatomegaly.The spleen was impalpable, and there were no signs of chronic liver disease.The persistence of symptoms prompted us to investigate for other, underlying pathological liver conditions.Serological markers for other hepatotrophic viruses (HBV, hepatitis C virus, cytomegalovirus, Epstein-Barr virus, adenovirus, herpes and rubella) were negative.All three patients were of the a,-antitrypsin phenotype MM on isoelectric focusing.Patient 3 had increased IgG levels (23 gm/L), with a smooth muscle antibody titer of 1/:80.We performed investigations for WD (Table 1).
Somalia operation just one of many demands on US military medicine
Authors: P. Gunby
Journal: JAMA (1993)

AN EVOLVING "new world order" is placing heavy demands on US military medicine. Air Force, Army, and Navy physicians were warned at a recent military medical school conference in Bethesda, Md (<i>JAMA</i>. 1992;268:577-578), that the world is in a state of "violent peace." Some 120 conflicts of various intensities have greeted this new year (<i>JAMA</i>. 1992;268:3480). One of the most dramatic, of course, is the conflict among clans in chaotic Somalia on the horn of Africa (<i>JAMA</i>. 1992;268:1985-1987 and 1991;265:1791-1797). About 28150 US troops have launched Operation Restore Hope there in recent days, with some 50 military physicians—working with other military medical personnel—to look after their health needs and sometimes those needs of part of the medically deprived populace. <h3>Somalia Just One of Many</h3> Elsewhere in Africa, the Air Force supported the United Nations—sponsored Operation Provide Transition, deploying a flight surgeon to Luanda, Angola, with 80 personnel and three C-130
Chlamydia trachomatis Genital Infections— United States, 1995
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 5181: Global alteration of CTCF binding in the cancer genome
Authors: Celestia Fang, Zhenjia Wang, Carlos A. Martinez, Panagiotis Ntziachristos, Chongzhi Zang
Journal: Cancer Research (2019)

Abstract The goal of this study is to understand the functions of altered CTCF binding in the cancer genome and its role in tumorigenesis. CTCF is a zinc finger protein that binds to DNA and functions as a transcriptional factor (TF) or a chromatin insulator. Disruption of individual CTCF bindings have been reported in several systems that associate with DNA methylation changes and result in aberrant chromatin interaction and differential expression of genes associated with the topological associated domains (TADs). We systematically analyzed over 500 CTCF ChIP-seq datasets across different human tissues and identified cancer-specific aberrant (gained) and disrupted (lost) CTCF binding sites in several cancer types. Through integrative analysis with other genomic data including RNA-seq, hi-C and DNA methylation profiles, we found that CTCF binding alterations correlate with differential chromatin interaction in the TADs, but most altered binding sites do not have DNA methylation changes. Instead, lost CTCF bindings at gene promoter regions associate with transcriptional repression, while gained bindings primarily occur in the distal enhancer regions bound by oncogenic transcription factors inducing gene expression. We validated these findings in T-cell acute lymphoblastic leukemia (T-ALL) using patient derived samples and identified NOTCH1 among oncogenic TFs bound at enhancers co-occupied with T-ALL-specific gained CTCF binding. These findings indicate that alteration of CTCF binding is an epigenomic signature of cancer cells, and our approach demonstrates a framework of integrating existing multi-omics data for mechanistic studies of cancer gene regulation. Citation Format: Celestia Fang, Zhenjia Wang, Carlos A. Martinez, Panagiotis Ntziachristos, Chongzhi Zang. Global alteration of CTCF binding in the cancer genome [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 5181.
FREQUENT CAUSES AND THE TREATMENT OF PERENNIAL HAY-FEVER
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Grundzüge der Elektrodiagnostik und Elektrotherapie für praktische Aerzte.
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Toxicologic Methods: Controlled Human Exposures
Authors: Mark J. Utell, Mark W. Frampton
Journal: Environmental Health Perspectives (2000)

The assessment of risk from exposure to environmental air pollutants is complex, and involves the disciplines of epidemiology, animal toxicology, and human inhalation studies.Controlled, quantitative studies of exposed humans help determine health-related effects that result from breathing the atmosphere.The major unique feature of the clinical study is the ability to select, control, and quantify pollutant exposures of subjects of known clinical status, and determine their effects under ideal experimental conditions.The choice of outcomes to be assessed in human clinical studies can be guided by both scientific and practical considerations, but the diversity of human responses and responsiveness must be considered.Subjects considered to be among the most susceptible include those with asthma, chronic obstructive lung disease, and cardiovascular disease.New experimental approaches include exposures to concentrated ambient air particles, diesel engine exhaust, combustion products from smoking machines, and experimental model particles.Future investigations of the health effects of air pollution will benefit from collaborative efforts among the disciplines of epidemiology, animal toxicology, and human clinical studies.
The Reliability of Medical Record Review for Estimating the Frequency of Medical Mistakes
Journal: Annals of Internal Medicine (2002)

Summaries for Patients4 June 2002The Reliability of Medical Record Review for Estimating the Frequency of Medical MistakesSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-136-11-200206040-00004 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?In 1999, the U.S. Institute of Medicine reported that mistakes in U.S. hospitals are alarmingly frequent. This report relied on studies that used doctors and nurses to review patients' medical records to identify mistakes. In these studies, the doctors and nurses looked at the medical records to first decide whether a patient had experienced a complication. Second, they had to decide whether the complication was related to medical care. Third, they needed to decide whether the complication was an expected side effect or was caused by someone's mistake. ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “The Reliability of Medical Record Review for Estimating Adverse Event Rates.” It is in the 4 June 2002 issue of Annals of Internal Medicine (volume 136, pages 812-816). The authors are EJ Thomas, SR Lipsitz, DM Studdert, and TA Brennan.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine. Previousarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe Reliability of Medical Record Review for Estimating Adverse Event Rates Eric J. Thomas , Stuart R. Lipsitz , David M. Studdert , and Troyen A. Brennan Metrics 4 June 2002Volume 136, Issue 11Page: I-40KeywordsAdverse eventsChartsHospital medicine ePublished: 4 June 2002 Issue Published: 4 June 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...