tbuckley/cabot-search huggingface dataset:
Chromatographic and Spectrophotometric Characterization of Adducts Formed during the Reaction of trans, trans-Muconaldehyde with 14 C-Deoxyguanosine 5 prime -Phosphate
Authors: Louise Latriano, Gisela Witz, Bernard D. Goldstein, Alan M. Jeffrey
Journal: Environmental Health Perspectives (1989)

Mice liver microsomes oxidatively open the benzene ring to form trans,trans-muconaldehyde, a hemato- toxic unsaturated aldehyde.In the present studies, 4.5 imole trans,trans-muconaldehyde was reacted with "4C-2'deoxyguanosine 5'-phosphate in phosphate buffer.Products were separated by high performance liquid chromatography (HPLC).Absorbance was monitored using a diode array detector, and aliquots of the HPLC eluant were collected for UV spectrophotometric analysis and scintillation counting.Under these conditions, deoxyguanosine 5'-phosphate eluted at 12.5 min and muconaldehyde at 22.0 min.The HPLC and radioac- tivity profiles of the muconaldehyde/deoxyguanosine reaction mixture indicated the presence of multiple ad- ducts.Three adducts were detected eluting at 36, 39, and 42 min, which represented approximately 2.5, 2.5, and 1% of the radioactivity, respectively.These adducts had similar UV spectra with absorption maxima be- tween 334 and 347 nm.Another product of the reaction mixture, eluting at 19.0 min and accounting for 10% of the radioactivity, was also observed.This compound had absorption maxima at 348 and 372 nm.These results suggest that trans,trans-muconaldehyde can react with deoxyguanosine monophosphate in vitro under physiological conditions to form stable adducts.Studies are being conducted to determine the structure of these adducts and whether these adducts are formed by the reaction of DNA with muconaldehyde or metabolically activated benzene.
Rapid Achievement of MR4.5 after Switching from Imatinib (IM) to Nilotinib (NIL) in Patients (Pts) with Chronic Myeloid Leukemia in Chronic Phase (CML-CP): Preliminary Results from ENESTgoal
Authors: Ellen K. Ritchie, Rosalind Catchatourian, Rebecca B. Klisovic, Michael W Deininger, Harry P. Erba, Jerald P. Radich, Michael R. Savona, Ghulam Warsi, Carole S. Paley, Ilva Dautaj, Felice P. Lin, Michael J. Mauro
Journal: Blood (2015)
Correction
Journal: BMJ (1955)

Rapid Weight Loss in the Elderly Q.-Apart from malignant disease and obvious acute ill- ness, whlat are the most likely causes of rapid loss of weight in elderly people.?A.-The question is difficult to answer without some in- formation to restrict the field of inquiry.If loss of weight was due to subacute bacterial endocarditis or tuberculosis, one would expect fever and an increased sedimentation reaction.If due to toxic goitre, which is easily missed in
Minutes of the Sixteenth Annual Session of the Nebraska State Medical Society, held at Omaha, Nebraska, May 13 and 14, 1884.
Journal: JAMA (1884)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Recent Decrease in US Rates of Invasive Cancer
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Honing Clinical Skills
Authors: Arthur S. Harrow
Journal: Annals of Internal Medicine (1993)

Letters15 May 1993Honing Clinical SkillsArthur S. Harrow, MDArthur S. Harrow, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-118-10-199305150-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Your editorial [1] regarding the relative value of the physical examination stirred memories: During my internship, my students and I spent one night examining a newly admitted patient who had a systolic murmur. Textbook review led us to dynamic cardiac examination techniques, including squatting and the Valsalva maneuver. By rounds the next morning, we presented a diagnosis of idiopathic hypertrophic subaortic stenosis and were prepared to back this up with rather elegant physical findings. The attending physician, a recently trained cardiologist, then spent 5 seconds listening to the heart and recommended an echocardiogram, noting that this will ...REFERENCE1. Fletcher RH, Fletcher SW. Has medicine outgrown physical diagnosis? Ann Intern Med. 1992; 117:786-7. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 May 1993Volume 118, Issue 10Page: 828KeywordsEndoscopyGastroenterology and hepatologyHeartMagnetic resonance imagingMemoryStenosisSystolic ejection murmur Issue Published: 15 May 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
High Resolution CT of the Chest - Comprehensive Atlas
Journal: Thorax (1996)

Book reviews stinal lymphadenopathy is not surprising.Paediatric series have emphasised the usefulness of bronchoscopy for the diagnosis of endobronchial disease associated with medi- astinal lymph node tuberculosis.2In adults Auregan et al reported that only three from a series of 140 patients with tuberculous medi- astinal lymphadenopathy had a normal fibr- eoptic bronchoscopic examination and that 135 patients had one or more bronchial fistu- lae.3We therefore agree with Baran and col- leagues that bronchoscopy is of significant diagnostic value in patients with isolated tuberculous mediastinal lymphadenopathy and may avoid more invasive procedures such as mediastinoscopy.However, rigid bron- choscopy with large sampling and/or trans- bronchial biopsy is probably not necessary in most patients.We believe that fibreoptic bronchoscopy with bronchial biopsy speci- mens should be considered as a first line examination in patients with apparently isolated tuberculous mediastinal lymphadenopathy.
Activation of Aromatic Amines to Mutagens by Bovine Bladder and Liver Cells
Authors: Linda Oglesby, Cathy Hix-Baker, Pat MacNair, Marianne Sieg, Linda Snow, Robert Langenbach
Journal: Environmental Health Perspectives (1983)

A bovine bladder cell-mediated mutagenesis system using Chinese hamster V79 cells and Salmonella typhimurium as target organisms was developed to investigate the capacity of the bladder urothelium to activate chemical carcinogens. Bovine bladder epithelial cells can activate the aromatic amines AF and 4-ABP to intermediates which mutate V79 cells and S. typhimurium TA 98 and TA 100. DMBA was mutagenic to V79 cells but not detectably mutagenic to either Salmonella strain with bladder cell activation. The chemicals tested were not mutagenic to either target organism in the absence of bladder cells. In contrast to the response with DMBA, S. typhimurium was a more sensitive target for the arylamines than V79 cells. These data suggest the value of using multiple end points for assessing metabolic capability. The activation capability of intact bladder cells was compared to disrupted cells, and S-9 prepared from bladder cells used with and without cofactors. When intact cells or S-9 plus cofactors were used as the activation system a dose-dependent increase in revertants was observed for 4-ABP. A bovine liver cell-mediated bacterial mutagenesis system was also developed and the liver and bladder systems compared. For AF, bladder cells appear to be at least ten times more active per viable cell than hepatocytes in producing mutagenic intermediates, while 4-ABP is essentially not mutagenic in the hepatocyte-mediated system. A quantitative comparison of the relative importance of the liver and bladder to activate the chemicals is difficult to make but the data indicate the ability of the bladder epithelium to activate bladder carcinogens.
Phase I/II study of PTK787/ZK 222584 (PTK/ZK), a novel, oral angiogenesis inhibitor in combination with FOLFIRI as first-line treatment for patients with metastatic colorectal cancer
Authors: N. Schleucher, T. Trarbach, U. Junker, M. Tewes, E. Masson, D. Lebwohl, S. Seeber, D. Laurent, U. Vanhoefer
Journal: Journal of Clinical Oncology (2004)

3558 Background: Increased angiogenesis is correlated with poor prognosis in patients with advanced metastatic colorectal cancer (CRC). PTK/ZK is a novel, oral angiogenesis inhibitor that potently inhibits all known VEGF receptor tyrosine kinases, important mediators in the formation of new blood vessels that contribute to tumor growth and metastasis. Methods: This trial determined the MTD and DLTs of once-daily oral PTK/ZK in combination with infusional 5-fluorouracil (5-FU)/leucovorin (LV) plus irinotecan (FOLFIRI) as first-line treatment in patients with metastatic CRC. PTK/ZK was administered orally once daily in escalating doses of 500, 1,000, and 1,250 mg/day to cohorts of 3–7 patients. FOLFIRI was administered q 2 weeks as irinotecan (180 mg/m2, day 1) plus LV (200 mg/m2, 2-hour infusion) and 5-FU (400 mg/m2 bolus followed by 600 mg/m2 as a 22-hour infusion) on days 1 and 2. Results: To date, 16 patients have been enrolled at 500 (n = 6), 1,000 (n = 7), and 1,250 (n = 3) mg/day. PTK/ZK was well tolerated; commonly reported grade 1/2 adverse events were nausea, fatigue, vomiting, epistaxis, diarrhea, and dizziness. There was 1 DLT at 500 mg/day (grade 3 fatigue) and 1 at 1,000 mg/day of PTK/ZK (grade 3 hypertension); both resolved uneventfully within 2 weeks of PTK/ZK discontinuation, and no other PTK/ZK-related severe toxicities have been observed. The pharmacokinetics of PTK/ZK was unaffected by FOLFIRI. Coadministration of 1,250 mg/day PTK/ZK with FOLFIRI had minimal effect on irinotecan exposure but lowered the AUC of SN38 in serum by ∼40%; the clinical relevance is under investigation. Preliminary efficacy results (by SWOG criteria) for 12 evaluable patients included 4 partial responses (33%) and 5 (42%) patients had stable disease. Median time to progression for 11 evaluable patients was 6.7 months (95% CI = 6.1, 7.1 months). At a median follow-up of 9.0 months, all 16 patients are alive. Conclusions: These preliminary results suggest that the combination of PTK/ZK with FOLFIRI is safe, well tolerated, and has activity in patients with metastatic CRC. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Novartis Pharmaceuticals Corp.; Schering AG Novartis Pharmaceuticals Corp.
Myocardial, metabolic and endothelial effects of trimetazidine in diabetic patients with ischemic dilated cardiomyopathy Gabriele Fragasso, Piermarco Piatti, Lucilla Monti, Gianpietro Valsecchi, Riccardo Camisasca, Emanuela Setola, Sergio Chierchia. Istituto Scientifico/Universit� San Raffaele, Milano, Italy
Journal: Journal of the American College of Cardiology (2001)
Antiepileptic Drugs
Authors: Joseph Fermaglich
Journal: JAMA (1990)

Forget about Danielle Steele, Stephen King, and Tom Wolfe for your vacation's reading. Pack this volume on the next trip, spend time with it, and savor the richness of its contents. For anyone interested in epilepsy, this book is a must. In the preface to this third edition, the editors affirm that its purpose is the same as that of the previous two— to "present in a single source all of the recent advances in knowledge concerning the antiepileptic drugs as well as an in-depth review of basic pharmacologic data from both animals and man." And it delivers—that and more. Indeed, it blends the colors of neurophysiology, neurochemistry, neuropharmacology, neuroepidemiology, neurotoxicology, neuroendocrinology, and clinical neurology into a striking tapestry that portrays the entire scene of neurological research and practice. In the first of the book's 14 sections, general principles of antiepileptic drugs are described. Subsequent sections deal with specific antiepileptic
Das Kystoskop.
Journal: JAMA (1910)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Malignant Lymphomas in Patients With or at Risk for AIDS in Italy: Italian Cooperative Group for AIDS- Related Tumor,*
Journal: JNCI Journal of the National Cancer Institute (1988)

For the first time the presence of a consistent number of malignant lymphomas (95 patients with non-Hodgkin's lymphoma and 35 with Hodgkin's disease) among persons with human immunodeficiency virus infection has been documented in Europe. In contrast to American patients with malignant lymphomas, who were reported to be predominantly homosexuals, the Italian patients were mostly iv drug abusers. Patients with non-Hodgkin's lymphomas had an increased incidence of high-grade subtypes and presented an advanced stage with frequent CNS (25 patients) but not anorectal or oral involvement. Patients with Hodgkin's disease had an increased incidence of mixed cellularity and lymphocytic depletion subtypes and stage III and IV disease. The occurrence of malignant lymphomas was correlated with a poor prognosis: median survival in patients with non-Hodgkin's lymphomas was only 4 months, while in patients with Hodgkin's disease it was 15 months.
Connect
Journal: Nature Genetics (1998)

Connect"Genetics.No-one knows about that.Or at least I don't", remarked a Swiss banker, resident for the last nine months in Manhattan, on contemplating the relationship between geneticists and 'the public' .His comment appears to be consistent with results from the recent survey 1 by the National Science Foundation (NSF), which assesses the degree to which the American public is scientifically 'literate' , amongst other parameters.One conclusion is that while American scientific literacyassessed by the ability of individuals to answer nine questions-is greater than that of other countries (although virtually equivalent to some European ones), it remains weak.This finding may come as a disappointing surprise to some, given a renaissance in the enthusiasm for 'scientific literacy' , and substantive initiatives, in the U.K. and U.S. especially, to promote the public understanding of science.Perhaps, however, the NSF results should not come as a surprise.The discipline of understanding how and why 'the public' learn-or are inspired to learnabout science is in its infancy; fifteen years ago, it did not exist.A shift in the relationship between cause and effect can take decades (as in: "don't mention the war").Additionally, the perception of a field will be informed, in part, by how those working in that field are perceived.One would hope that the traditional models of the Scientist are now considered passé: the scientist (usually male) as a deity of knowledge, who bestows from on high the seal of "scientifically proven" on consumables, or, almost conversely, a 'techno-freak' who willfully 'plays God' , eyes bulging and sweaty-palmed, behind closed doors.Judging from a random cull of recent media fare, it appears not.These perceptions establish an 'us-them' relationship and discourage the kind of empathy that is necessary for constructive dialogue.Of course, many journalists do a stellar job in communicating not only science itself, but the societal implications of and concerns about procedures and results.They also do a good job at 'demystifying' the Scientist.See, for example, the Pullitzer-prize-winning Chicago Tribune articles on the human genome and human genome diversity projects 2,3 .The opportunity to contribute to public debate, or to present one's work in the public domain would seem to be a good thing, if done with care and accuracy.As noted by Robert Finn in his introduction to a series of on-line articles that advise scientists on how to interact with journalists (http://biomednet.com/hmsbeagle/1997/08/people/pressbox.htm),scientists who take on a more 'public' role are often volume 19 no. 4 august 1998 " "Scientists say that men use 10% of their brains.And that's the good news.-American Broadcasting Corporation (12 July, 1998)" "… They may not be the best scientists.They may not have the fanciest machines, the sharpest tools.But they seem to share something else.
Dobutamine Overdose
Authors: Paul M. Paulman
Journal: JAMA (1990)

<h3>To the Editor.—</h3> An inadvertent overadministration of intravenous dobutamine recently occurred at our hospital. A 47-year-old woman, admitted for urosepsis, mistakenly received another patient's dobutamine instead of the intravenous antibiotics ordered. Although the dobutamine was labeled appropriately, this medication was hung and administered to the patient at more than 130 μg/kg per minute for 30 minutes. This rate is three times the recommended maximum intravenous dosage (40 μg/kg per minute) and approximately 150% of the previously reported maximum dose of 80 μg/kg per minute.<sup>1</sup> The error was discovered by the nursing staff within minutes of completion of the dobutamine infusion, and the house officer on call was notified. On initial evaluation, the patient complained of being very anxious and "jittery." Her blood pressure was 170/80 mm Hg with a baseline of 108/60 mm Hg. She was also tachycardic (120 beats per minute) and tachypneic (respirations, 30/min). The patient complained
Poor Fergus!
Authors: G. G. Liddle
Journal: JAMA (1970)

<h3>To the Editor.—</h3> A recent visit to the editorial rooms of a medical journal proved to be an unnerving experience. I hope that events of this nature do not disturb the offices ofThe Journal. Standing beside an editor's desk, I saw a fly crawling among a profusion of scattered papers. As I raised my hand to strike, the editor seized my arm and exclaimed, "Don't! That's Fergus, a friend of R's." The next morning I visited R in his office to ask about Fergus. "Oh, yes," said R, "there's Fergus perched on the 'out box' where he can watch me write." "What do you feed him?" R scorned me with a look. "I don't feed him anything. I don't even give him any of the editorial coffee. Afternoons he forages in the editor's office next door, where there's plenty of rubber cement." During the week I met Fergus on
Pancreas transplantation
Authors: Patrick G Dean, Aleksandra Kukla, Mark D Stegall, Yogish C Kudva
Journal: BMJ (2017)

The treatment of patients with diabetes mellitus (DM) presents many challenges to care providers and represents a major proportion of healthcare expenditure worldwide. Successful pancreas transplantation provides durable glycemic control and improves survival for patients with diabetes. Progress in the field has mainly been based on large single center studies and the cumulative analyses of registry data from the United Network for Organ Sharing (UNOS) and the International Pancreas Transplant Registry. This review focuses on the outcomes of pancreas transplantation for patients with and without end stage renal disease. It describes the current state of pancreas transplantation, gaps in knowledge, and future studies needed to enable more patients to benefit from this treatment. A common theme that emerges is the need for multicenter randomized trials in pancreas transplantation to define clearly the efficacy, risks, and long term benefits.
Atypical mycobacteriosis of the urinary tract. A case report of extensive disease caused by the Battey bacillus
Authors: M. Pergament
Journal: JAMA (1974)

CHRONIC pulmonary disease caused by atypical mycobacteria is a well-recognized entity characterized by granulomatous lesions resembling those of tuberculosis. Involvement of the urinary tract by these organisms is not so well known, with only two case reports in the literature.<sup>1,2</sup>The case reported here is the first instance wherein a Runyon type 3 organism has been shown capable of producing the same extensive clinical and roentgenographic patterns seen in tuberculosis. <h3>Report of a Case</h3> A 62-year-old woman gave a six-month history of frequency, urgency, nocturia, and suprapubic and right lower quadrant pain that had been associated with gross hematuria for the previous two months. Born in southern Minnesota, she has lived there since. As a young adult, she had transient episodes of left midabdominal and left flank pain. There has not been any known contact to tuberculosis. No further symptoms had developed until 1970, when she was treated for