tbuckley/cabot-search huggingface dataset:
Brignole
Authors: Anne P. Rogal
Journal: Annals of Internal Medicine (1998)

On Being a Doctor15 April 1998BrignoleAnne P. Rogal, MDAnne P. Rogal, MDBrookline, MA 02167Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-8-199804150-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail I dreamt of Brignole last night. Once again I saw his handsome dark face and his slender form. He was dressed in khaki pants and the winter jacket my mother had bought him a year before he died. In the dream, we held each other in a long embrace.His real name was Claude Louis, but as a resourceful young man trying to get out of Haiti, he had purchased a false passport and successfully completed his illegal immigration under the unusual name of Brignole Brisilien. Or was it Brisilien Brignole? Medical records never could figure it out, and I ... Author, Article, and Disclosure InformationAffiliations: Brookline, MA 02167Corresponding Author: Anne P. Rogal, MD, 200 South Street, Brookline, MA 02167. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 April 1998Volume 128, Issue 8Page: 691-692KeywordsAIDSFallsFeversOilsPregnancyResearch laboratoriesStrokeTouchVertebraeWeight gain Issue Published: 15 April 1998 CopyrightCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Family Psychiatry: From Research to Practice
Authors: Alison Heru
Journal: American Journal of Psychiatry (2006)

Objective: The purpose of this article is to review current research evidence for clinicians involving families in the assessment and treatment of their patients. Method: Research on effects of family support on illness outcome and outcomes of family-centered treatment in medicine, pediatrics, and psychiatry are reviewed. Results: Research in many medical fields shows that families have powerful influences on health that are equal to or surpass other risk factors and that brief family interventions increase health and decrease the risk of relapse in chronic illnesses. Research in psychiatry affirms that family interventions reduce the rate of relapse, improve recovery, and increase family well-being. Conclusions: Current evidence supports increased emphasis on family-oriented psychiatric practice.
Abstracts
Journal: Annals of the Rheumatic Diseases (1951)

difference lies in the constitution of the individual, and this may account for the observation that scarlet fever generally attacks large, healthy, robust children, whereas those with rheumatic fever tend to be below average size and of poor physique.Marianna Clark.The Q-T Interval in Rheumatic Disease in Children.TARAN, L. M., and SZILAGYI, N. (1951)
Editorial: Student counselling.
Journal: BMJ (1976)

A recent study' of the first-year students at an American State University who asked for help from the counselling and mental health services showed that many of them were academically inadequate.Only in a few cases, however, could this academic underachievement be linked with emotional problems of the kind which might be helped by counselling or therapy.Most of the students did not disclose their academic difficulties to the counsellors, and they did not seem to benefit academically from their contact.They would probably have benefited more from academic and educational advice, and the American report highlights the lack of cross-referral between agencies and failure on the part of the counsellors and psychotherapists to take adequate histories of academic performance.
A macroregenerative nodule containing multiple foci of hepatocellular carcinoma in a noncirrhotic liver
Authors: N Theise
Journal: Hepatology (1993)

We report an incidental small hepatocellular carcinoma in a patient with chronic hepatitis C infection without cirrhosis. The existence of portal triads and the Meyenburg complexes within the lesion and atypical subnodules suggests that the carcinoma has arisen in the context of a macroregenerative nodule rather than the whole nodule being an early, spreading carcinoma. A growing body of evidence supports macroregenerative nodules as being precursor lesions in the development of hepatocellular carcinoma. Although they are generally thought of as being large cirrhotic nodules, this case suggests that they may be lesions that develop in the context of chronic liver disease, parallel to, but independently of, cirrhosis. Moreover, the development of carcinoma within the nodule suggests that macroregenerative nodules may play a role in carcinogenesis in noncirrhotic livers. (HEPATOLOGY 1993;17:993–996.)
DNA Vaccines
Authors: W M McDonnell, F K Askari
Journal: New England Journal of Medicine (1996)

The feasibility of using DNA as a treatment has been demonstrated in animal models, but clinical applications of this form of technology remain elusive. When gene therapy does come into wide medical use, it may be as a vaccine. Difficulties in developing vaccines against chronic infections with viral agents such as the human immunodeficiency virus (HIV), herpes simplex virus, and hepatitis C virus are partly due to the poor immunogenicity of standard vaccines; these problems have spurred the development of new vaccine strategies that use DNA instead of protein.DNA vaccines contain the gene or genes for an antigenic portion . . .
SANITARY CONDITIONS OF STREET CARS.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Macrocytic anemia and thrombocytosis associated with thymoma: A case report
Authors: Elke Grumbeck, Paul Aiginger, Bettina Gisslinger, Klaus Geissler, Renate Thalhammer‐Scherrer, Heinz Gisslinger
Journal: American Journal of Hematology (2000)

Thymomas are often associated with autoimmune disorders. We report on a 45-year-old female patient with thymoma and hypogammaglobulinemia (Good's syndrome) who developed symptomatic macrocytic anemia (Hb 4.4 g/dl, MCV 112 fl) and thrombocytosis (Plt 442 G/l). Besides hypogammaglobulinemia (IgG 589 mg/dl), an inverted ratio of CD4+/CD8+ cells was seen. The bone marrow biopsy showed a slightly hypercellular bone marrow with normal granulopoiesis, normal megakaryopoiesis and a mild dyserythropoiesis without any ring-sideroblasts. The in-vitro stem cell culture from the bone marrow revealed an atypical growth of macroclusters, reduced BFU-E and CFU-GEMM colony growth, whereas the CFU-GM colony growth was within the normal range. The chromosomal analysis showed a normal karyotype. The plasma vitamin B12 and folate levels were within normal ranges, and we could not detect any autoantibodies. These findings excluded the differential diagnoses pure red cell aplasia (PRCA) and pernicious anemia. After resection of the thymoma of mixed cell type, the macrocytic anemia and thrombocytosis disappeared. The clinical course was complicated by a cerebral palsy and a life-threatening fungal septicemia after surgery. In the third year after thymectomy, hyporegenerative macrocytic anemia and thrombocytosis reappeared and an immunosuppressive treatment with prednisolone (1 mg/kg BW) was started. After initiation of the prednisolone therapy, reticulocyte counts increased and macrocytic anemia as well as thrombocytosis disappeared. The normalization of these laboratory parameters during glucocorticoid therapy suggests that in rare cases the constellation of macrocytic anemia, thrombocytosis and hypogammaglobulinemia may be due to an underlying immunologic mechanism. Am. J. Hematol. 63:38–41, 2000. © 2000 Wiley-Liss, Inc.
Tuberculosis Target
Authors: Tracy Hampton
Journal: JAMA (2011)

Research on tuberculosis (TB) led by scientists in New Delhi, India, reveals that the strategy that Mycobacterium tuberculosis uses to evade the immune system may involve recruiting stem cells to sites of infection (Raghuvanshi S et al. Proc Natl Acad Sci U S A. 2010;107[50]:21653-21658).
Book Review Compendium of Regional Diagnosis in Lesions of the Brain and Spinal Cord: A concise introduction to the principles of localization of diseases and injuries of the nervous system . By Robert Bing. Translated and edited by Webb Haymaker. 11th edition. 4°, cloth, 292 pp., with 125 illustrations and 7 plates. St. Louis: C. V. Mosby Company, 1940. $5.00.
Journal: New England Journal of Medicine (1940)
Cornerstone of Medical School Laid.
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hepatobiliary function in senescent male Sprague-Dawley rats
Authors: J Handler
Journal: Hepatology (1994)

The purpose of these studies was to investigate intrahepatic changes underlying age-related decreases in bile flow by evaluating the effects of aging on bile acid–dependent and –independent flow, canalicular versus ductular flow and hepatic tight junction permeability. The isolated perfused liver was used to assess age-related changes in intrinsic hepatobiliary function without the complications of extrahepatic factors such as circulating hormones or hemodynamics. Livers from young adults (3 to 6 mo old) or senescent (22 to 26 mo old) male Sprague-Dawley rats were isolated and perfused in a nonrecirculating, hemoglobin-free system to assess oxygen uptake, bile acid–dependent and -independent bile flow, bile acid uptake, carbon 14–labeled erythritol clearance as a measure of canalicular flow, tight junction permeability and transcellular transport into bile. Rates of oxygen uptake by livers from senescent rats were significantly lower than those of young adults (75 ± 8 μmol/gm/hr vs. 121 ± 5 μmol/gm/hr). Age-related decreases in total bile flow were observed and were associated with similar reductions in 14C-erythritol clearance suggestive of decreased canalicular bile flow. Bile aciddependent and –independent flow was decreased by 50% and 60%, respectively, in isolated perfused livers from senescent rats. Hepatocellular uptake of taurocholate and rates of bile acid excretion also were about 50% lower in senescent than in young adult rats. Tight junction permeability and transcellular transport were assessed by monitoring appearance of tritiated inulin and horseradish peroxidase in bile after bolus injections of these compounds through the portal vein. Tritiated inulin appearance in bile was decreased slightly in senescent compared with young rats. No age-related differences in tight junction permeability to horseradish peroxidase were observed. In addition, biliary excretion of horseradish peroxidase in livers from senescent rats was not affected by colchicine, suggesting that microtubule-related transport was minimal or absent in the senescent rats. Taken together, these data indicate that decreased rates of bile flow in senescent compared with young rats are caused by age-related effects on intrinsic hepatobiliary function, specifically decreases in canalicular bile flow associated with decreased bile acid–dependent and –independent bile flow. The decreased canalicular bile flow appears to be a result in part of impairment of energy-dependent transport processes and microtubule-dependent transcellular transport across cells. These findings suggest that changes in intrinsic hepatobiliary function occur in aged populations and are not caused exclusively by extrahepatic effects such as altered blood flow or changes in hormonal status. Further, age-related decreases in bile flow may be caused at least in part by decreased active transport of osmotically active solutes into bile. (HEPATOLOGY 1994;19:1496–1503.)
Science, Washington
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ocular Trauma
Authors: Yi-Hsun Huang, Fu-Chin Huang
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical evaluation of rapid point-of-care testing for detection of novel influenza A (H1N1) virus in a population-based study in Spain
Authors: Victoria Ortiz de la Tabla, Pedro Antequera, Mar MasiÃ¡, Pilar Ros, Coral Martin, Gregoria Gazquez, Fernando BuÃ±uel, Victoria SÃ¡nchez, Catalina Robledano, FÃ©lix GutiÃ©rrez
Journal: Clinical Microbiology and Infection (2009)
Bronchial Asthma
Authors: Joseph Rebhun
Journal: JAMA (1963)

<h3>To the Editor:</h3> —In "Letters to the Journal" of Feb 23, 1963, p 717, I read a concise short outline on how to treat bronchial asthma effectively. I would like, humbly, if I may, to add only one more avoidance to the six already recommended by the author of the article, "Bronchial Asthma." That is that younger colleagues, who look up to the authorities with 24 yr of experience, avoid such oversimplification in treatment of asthma so their patients might not have the awful luck of those who were treated by the author of the mentioned article.
AB0162 Rank Expression is Reduced in Circulating Monocytes from Ankylosing Spondylitis Patients
Authors: I.P. Perpétuo, J. Caetano-Lopes, E. Vieira-Sousa, R. Campanilho-Marques, C. Ponte, H. Canhão, M. Ainola, J.E. Fonseca
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Rheumatoid arthritis (RA) and ankylosing spondylitis (AS) are systemic, immune-mediated diseases. RA9s main targets are the peripheral joints while AS has the axial skeleton and enthesis as the principal affected areas. RA is characterized by bone erosions and impaired repair whilst AS is typified by bone overgrowth. The causes for these differences are not yet understood; however we hypothesize that AS patients9 monocytes receive reduced osteoclastogenic stimuli and/or have abnormal capacity to respond to them. <h3>Objectives</h3> The aim of this study was to characterize AS patients9 bone remodeling and pro osteoclastogenesis inflammatory environment and monocyte phenotypes as compared to RA patients and healthy controls. <h3>Methods</h3> Untreated AS or RA patients with active disease and age and gender-matched healthy donors were recruited for this study. Blood was collected for flow cytometry measurements of RANKL expression and monocyte subpopulation characterization. Serum was collected for cytokine and bone remodeling factors quantification. This study was approved by the hospital9s ethics committee. <h3>Results</h3> We found that RANKL T and B lymphocyte expression was significantly higher in AS and RA patients when compared to healthy donors (p=0.0445 and 0.0016, respectively). Frequency of both classical (CD14brightCD16negative) and non-classical (CD14dimCD16positive) was increased in AS and RA patients when compared to healthy donors (p&lt;0.0001 and p=0.0227, respectively). However, in the classical subpopulation RANK expression was lower in AS patients as compared to RA patients and healthy controls (p=0.0073). In accordance, CTX-I and P1NP serum level were also lower in AS patients than in healthy controls (p=0.0100 and p=0.0195, respectively). <h3>Conclusions</h3> Despite comparable osteoclastogenic stimuli in AS and RA patients, RANK expression is reduced in AS circulating monocytes which may contribute to the bone forming phenotype observed in AS patients. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.5730
Blocking IL-1 signaling in hepatocytes undergoing metabolic stress protects against metabolic inflammation and attenuates pro-coagulant factors
Authors: Nadine Gehrke, Beate Straub, Nadine Hoevelmeyer, Ari Waisman, Detlef Schuppan, Marcus-Alexander Woerns, Peter Galle, Jörn M. Schattenberg
Journal: Journal of Hepatology (2020)
THE IDEALS OF THE ASSOCIATION.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Applying the phenotype approach for rosacea to practice and research
Authors: J. Tan, M. Berg, R.L. Gallo, J.Q. Del Rosso
Journal: British Journal of Dermatology (2018)

This thoughtful article has been presented by a group of authors from departments in Canada, Sweden and the USA. The central point of this article is the case for a different approach to the classification of the skin disease, rosacea, although the argument is also relevant to other diseases. Currently rosacea is divided into a number of different subtypes based on presence or absence of flushing or transient redness of the face, swelling of the nose, small spots (without or without heads) and broken veins or telangiectases. The authors are arguing for a less restricted approach which uses a combination of different terms, some of which are regarded as major and others as minor, that together best describe the changes on the skin that each patient shows to account for the fact that patients may have several such changes at the same time or one may evolve into another. It also allows greater flexibility. Adopting this "phenotype" approach, and thereby taking into account all the features of the condition, would allow better assessment of the effects of treatment on each patient, in clinical trials, or in understanding the disease, or the impact of rosacea on a patient's life. How we describe things in medicine often limits our ability to understand disease and its treatment and impact. This paper argues for greater flexibility in using what we see to classify illness.
Regulation of the Differentiation of PC12 Pheochromocytoma Cells
Authors: Ko Fujita, Philip Lazarovici, Gordon Guroff
Journal: Environmental Health Perspectives (1989)

The PC12 clone, developed from a pheochromocytoma tumor of the rat adrenal medulla, has become a premiere model for the study of neuronal differentiation. When treated in culture with nanomolar concentrations of nerve growth factor, PC12 cells stop dividing, elaborate processes, become electrically excitable, and will make synapses with appropriate muscle cells in culture. The changes induced by nerve growth factor lead to cells that, by any number of criteria, resemble mature sympathetic neurons. These changes are accompanied by a series of biochemical alterations occurring in the membrane, the cytoplasm, and the nucleus of the cell. Some of these events are independent of changes in transcription, while others clearly involve changes in gene expression. A number of the alterations seen in the cells involve increases or decreases in the phosphorylation of key cellular proteins. The information available thus far allows the construction of a hypothesis regarding the biochemical basis of PC12 differentiation.