tbuckley/cabot-search huggingface dataset:
Vorolanib (CM082), everolimus, and the combination in patients with pretreated metastatic renal cell carcinoma (CONCEPT study): A randomized, phase 2/3, double-blind, multi-center trial.
Authors: Jun Guo, Xinan Sheng, Dingwei Ye, Zhisong He, Ai-Ping Zhou, Xin Yao, Zengjun Wang, Benkang Shi, Xinhua Tu, Yanqiao Zhang, Chaohong He, Cheng Fu, Zhigang Ji, Bo Yang, Bin Wu, Shukui Qin, Zhiquan Hu, Fang-Jian Zhou, Jianming Guo, Fenlai Tan
Journal: Journal of Clinical Oncology (2018)

TPS4605 Background: VEGF and mTOR pathways play key role in the development of renal cell carcinoma (RCC), the combination of agents targeting both VEGF- and mTOR-mediated pathways have been investigated with distinct results. Vorolanib (CM082) is a potent and selective inhibitor of VEGFR and PDGFR. Previous phase 1 study (NCT02577458) found that the combination of vorolanib 200 mg plus everolimus 5mg was associated with manageable toxicity consistent with individual agents and no new safety signals, antitumor activities was also seen in 35.7% patients with RCC patients who progressed on at least one VEGFR TKI therapy. Based on these findings, we conducted the CONCEPT study, a randomized, phase 2/3, double-bind, multicenter trial to assess vorolanib, everolimus, or their combination as second-line treatment in Chinese patients with metastatic RCC. Methods: Patients with cytologically or histologically confirmed RCC who had disease progression after one prior VEGFR TKI were eligible for participation in the study. They will be randomized by 1:1:1 ratio to receive matching placebo plus vorolanib or everolimus, or the combination. Randomization was stratified according to the MSKCC risk scores. The sample size was specified assuming a hazard ratio (HR) of 0.60, equating to an expected 6.5 months for everolimus and 10.5 months for vorolanib with or without everolimus. To provide 80% power at a two-sided 5% significance level, and an estimated 20% dropout rate, a total of 390 patients are required. This study is registered as NCT03095040. Progression: This study in conducted in 35 centers in China, so far 32 centers have been activated. Recruitment was started since March 10, 2017, and a total of 101 patients were randomized currently. Clinical trial information: NCT03095040.
Gastroenterology, Baltimore
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The 1988 JAMA Peer Reviewers List
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 650: Effect of antigen retrieval on immuno-based microdissection methods
Authors: Michael Tangrea, Meeiyueh Liu, Adam Roberge, Kristen Noyes, Kennedy Sanders, Michael Emmert-Buck, Donald J. Johann
Journal: Cancer Research (2018)

Abstract Introduction - Immunohistochemical staining (IHC) of histological sections is a well-established and useful technique for a large number of research studies and clinical applications, and is increasingly used as a targeting strategy for procurement of labeled cells via tissue microdissection, including immuno-LCM, immuno/computer-LCM, expression microdissection, and other techniques. The antigen retrieval (AR) process employed at the beginning of most IHC protocols increases epitope availability and improves staining characteristics; however, the procedure can damage DNA to an unknown extent. Experimental Procedures - To better understand the effects of AR on DNA quality and quantity, model system samples (lung cancer PDX tissue) and clinical specimens (KRAS gene mutation positive cases) were subjected to commonly employed AR methods [heat induced epitope retrieval (HIER), protease digestion] and the effects on DNA were assessed by Qubit, Fragment Analyzer, agarose gels, kappa qPCR, digital droplet PCR, NGS library preparation, and targeted sequencing. Data Summary - The results showed that HIER resulted in optimal staining characteristics, but induced significant damage to DNA, producing extensive fragmentation and decreased yields. Variation in the HIER protocol mitigated but did not eliminate the negative effects. In contrast, the consequences of protease treatment on DNA were relatively minor and immunostaining quality was acceptable, although diminished in intensity compared to HIER treated sections. Apart from the AR procedure, the IHC process itself also resulted in a decreased yield of DNA. However, in spite of the observed deleterious effects on DNA, none of the AR methods combined with IHC negatively affected PCR amplification of small amplicons, and KRAS gene mutations were successfully identified in the clinical cases under all conditions. Conclusions - The data indicate that DNA recovered from histology slides after standard AR and IHC processing can be successfully employed for the majority genomic applications, but studies that require larger DNA fragments such as long-read sequencing should avoid the use of HIER. Citation Format: Michael Tangrea, Meeiyueh Liu, Adam Roberge, Kristen Noyes, Kennedy Sanders, Michael Emmert-Buck, Donald J. Johann. Effect of antigen retrieval on immuno-based microdissection methods [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 650.
COURAGEOUS DEVOTION OF SCIENTIFIC INVESTIGATORS
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mechanisms underlying transcription factor deregulation in acute lymphoblastic leukemia
Authors: Jan Cools
Journal: HemaSphere (2018)

1VIB Center for Cancer Biology, Leuven 2KU Leuven Center for Human Genetics, Leuven, Belgium This is an open access Abstract Book distributed under the Attribution-NonCommercial-NoDerivs (CCBY-NC-ND), which allows third parties to download the abstracts and share them with others as long as they credit the author and the abstract book, but they cannot change the content in any way or use them commercially. http://creativecommons.org/licenses/by-nc-nd/4.0
Vibrio vulnificus sepsis associated with coincidental diagnosis of acute myeloid leukemia
Authors: Avichai Shimoni, Jakob Borchardt, Zvi Landau, Hannah Rosenbaum, Alain Berrebi
Journal: American Journal of Hematology (1998)

The letter published in the November 1997 issue, regarding simultaneous occurrence of lupus anticoagulant (LA) and factor VIII inhibitors [1,2], is very interesting.We agree with Dr. D.A. Triplett that it is of critical importance to differentiate an LA from a factor VIII inhibitor.Strict observance of the criteria recommended by the SSC Subcommittee on Lupus Anticoagulant/Phospholipid-Dependent Antibodies [3] is essential for this purpose.More than one test, with different assay principles, is necessary to screen for an LA, mainly in patients with other simultaneous coagulation defects, such as a neutralizing inhibitor or a factor deficiency.In a recently published study of 170 consecutive hemophilia A patients, we found 36 hemophiliacs who fulfilled the criteria for the diagnosis of LA, 18 of them with a time-dependent effect.It is possible that subjects with a strong time-dependent effect may have both a factor VIII inhibitor and an LA (n ‫ס‬ 12) [4].LAs were diagnosed based mainly on diluted Russell viper venom time (dRVVT).The activated partial thromboplastin time (APTT) is affected by factor VIII inhibitors; however, the platelet neutralization procedure of the APTT showed similar results to those obtained for dRVVT, except in three patients with positive dRVVT, for whom the shortening of the PNP was not sufficient to be considered positive.In our study, the StaclotLA results agreed with those from dRVVT; 8/8 were positive on LAs and 3/3 were negative on factor VIII inhibitors.We believe that factor VIII inhibitors could be masked by LA and the misdiagnosis could delay the prescription of the appropriate therapy [5].The above evidence stresses the need to develop a specific test to identify factor VIII inhibitors without interference of LA, and vice versa.
A matter of faith, not science’: analysis of media coverag of prostate cancer screening in Australian news media 2003-2006
Authors: Ross Mackenzie, Simon Chapman, Simon Holding, Kevin McGeechan
Journal: Journal of the Royal Society of Medicine (2007)

Objective Despite a near universal absence of evidence-based policies supporting population screening for prostate cancer, the prostate-specific antigen (PSA) test is aggressively promoted in the media as a life-saving form of screening. The objective of this study was to examine media coverage of prostate-cancer screening in Australia. Design Frame analysis of all direct or attributed quotes about prostate cancer. Setting Australian capital city newspapers (February 2003-December 2006) and Sydney television news (January 2003-December 2006). Main outcome measures Quotes regarding prostate cancer screening: n=436 in newspapers and television news. Results Seven rhetorical frames were identified. 86% of all quotes framed prostate screening and its outcomes as desirable, associating PSA testing as being consonant with other early-detection cancer-control messages. Adverse surgical sequelae to screening were often minimized, scientific progress highlighted and gender equity appeals appropriated. Those questioning screening were vilified, with epidemiology being framed as an inferior form of knowledge than clinical experience. Conclusions Australian men are exposed to unbalanced and often non-evidence-based appeals to seek PSA testing. There is a disturbing lack of effort to redress this imbalance.
Antonio Maria Valsalva (1666-1723), Valsalva maneuver
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical Neurophysiology
Authors: Roberto P. Segura
Journal: JAMA (1982)

This book, the first of a series dealing with a variety of neurological disorders, is a multiauthored approach to clinical neurophysiology. Chapters are by clinician investigators who have demonstrated interest and expertise in the areas covered. It is the goal of the editors to review comprehensibly several major areas of "Clinical Neurophysiology," a term the editors explain adequately in their initial chapter. It is a difficult task to condense the different and very extensive subjects into single chapters. This necessarily requires exclusion of some material. The chapters on EEG monitoring, sleep, and evoked responses are good basic reviews. Although they appear extremely succinct, a good list of up-to-date references is provided at the end of each chapter for further reading. The chapters on motor unit differentiation and fatigue are excellent. Quantitative electromyography (EMG) is better covered here than in most specialized EMG manuals. New research techniques and the complicated approach
Hypokalaemia induced by a combination of a beta-blocker and a thiazide.
Journal: BMJ (1982)

standard deviations below the mean, and the authors would need to measure the plasma potassium in more than 2000 patients taking a thiazide before they could expect to turn up a similar case.2An event of such rarity is hardly a sound reason for changing ordinary practice.Rather it is an indication for detailed in- vestigation of the individual patient, and the authors should perhaps have excluded syn- dromes of mineralocorticoid excess other than hyperaldosteronism (for example, liquorice abuse) and other factors contributing to hypokalaemia (for example, laxative abuse).Incidentally, "closely monitored" is a phrase with little meaning to the practising doctor- does it mean measurement daily, weekly, monthly, or what?Dr Skehan and his colleagues state that an increased incidence of ventricular arrhythmias after myocardial infarction is a "complication" of hypokalaemia, quoting a recent paper3 in support.The study cited did not establish a causal relationship between hypokalaemia (or diuretic use) and arrhythmias, and one of the authors of the article concerned has in fact conceded this.4At present there is no sound evidence that the mild or moderate hypokalaemia which generally accompanies thiazide treatment is harmful, nor do we know that it is harmless.The question is clearly very important, and there is considerable commercial interest in promoting the supposed risks of hypokalaemia.Reports which give undue weight to rare events, and which accept uncritically the supposed risks of hypokalaemia, are unlikely to lead to more rational management of diuretic-induced hypokalaemia.
A Primer on the Status Of Biochemical Research
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TORUS PALATINUS
Authors: John E. Lane
Journal: JAMA (1927)

In 1909, Godlee<sup>1</sup>began an article on torus palatinus as follows: In May of last year Dr. Morriston Davis brought to me a lady, aged 58, . . . on account of a small projection obviously of bone, terminating posteriorly a median ridge in the hard palate. . . . Up to that time I had never heard of the torus palatinus and, surgeon-like, I suggested the removal of the supposed exostosis. But my ardor was damped by the deaf husband mistaking my suggestion that it was congenital, for one that it was hereditary, and stating in confirmation that her daughters had the same peculiarity. . . . Naturally, I made inquiries among the dentists, and it at once became clear that to some of them the swelling was familiar. It is quite likely that physicians who are familiar with this not uncommon anomaly have had an experience similar to Godlee's. Several patients have been referred
SURVIVAL FOLLOWING IMPLANTABLE CARDIOVERTER-DEFIBRILLATOR IMPLANTATION IN PATIENTS WITH CARDIAC AMYLOIDOSIS
Authors: Angela Higgins, Amarnath Annapureddy, Yongfei Wang, Karl Minges, Rachel Lampert, Lynda Rosenfeld, Daniel Jacoby, Jeptha Curtis, Edward Miller, James Freeman
Journal: Journal of the American College of Cardiology (2019)
Health groups pin antitobacco hopes on turn-of-century high school class
Authors: A. T. Berggren
Journal: JAMA (1991)

APPROXIMATELY 20% of US high school seniors still smoke, according to the American Cancer Society. In hopes of substantially reducing that percentage by the close of this decade, the cancer society, American Heart Association, and American Lung Association continue to be involved in a 12-year tobacco education and awareness program for the elementary, junior high, and high school years. It was set into motion in 1988, when the high school class of (the year) 2000 entered first grade (<i>JAMA</i>. 1988;260:13-14; and<i>JAMA</i>. 1988;260:1836). These children now are in the fourth grade. The three sponsoring organizations are hoping that, whether a given class member goes on to earn his or her high school diploma or not, the individual will be part of the first smoke-free generation. This "Smoke-Free Class of 2000" project involved sending kits to more than 60 000 first-grade teachers around the country in its first year. Follow-up mailings
Bone Marker Directed Dosing of Zoledronic Acid for the Prevention of Skeletal Complications in Patients with Multiple Myeloma: Primary Analysis Results of the Z-MARK Study
Authors: Noopur Raje, Robert Vescio, Charles W. Montgomery, Ramakrishnan Parameswaran, Diep Tran, Ghulam Warsi, Eliza Argonza-Aviles, Solveig G. Ericson, Kenneth C. Anderson
Journal: Blood (2011)
LONDON LETTER.
Authors: None S.
Journal: JAMA (1884)

The Patent Medicine Stamp Act—the English Board of Inland Revenue Decision against Nostrums, Specifics, and Legitimate Foreign Drugs. London, July 14, 1884. The recent decision of the Board of Inland Revenue against legitimate foreign drugs, as well as all patent medicine, has caused great dissatisfaction among both the medical and pharmaceutical professions throughout the Kingdom. It appears that the action of the Board was made specially upon the medicinal preparations of Park, Davis &amp; Co., many of which are now being largely used inGreatBritain. The Stamp Act of 1812, which has thus been unjustly interpreted by the board against the profession of this country, was in vogue when both pharmacy and medicine were in their infancy. English pharmacists and physicians no longer depend upon their own home products for fine preparations and good therapeutic results, but upon the valued remedies obtained from all parts of the world. In
Nephrology
Authors: Richard J. Glassock
Journal: JAMA (1987)

The translation of new insights derived from fundamental research to the field of clinical nephrology is occurring at an increasing pace. Two recent developments directly stem from the revolution in biomedical science brought about by the remarkable tools of molecular biology. The first was cloning, in 1984, the gene responsible for the production of human erythropoietin,<sup>1,2</sup>followed by its insertion into a mammalian cell-line vector, allowing large-scale synthesis of the pure harmone.<sup>3</sup> Erythropoietin is a 166—amino acid polypeptide with molecular weight of 34 000 daltons, which is secreted as a glycosolated product.<sup>4</sup>The anemia that accompanies chronic renal failure is primarily due to the kidneys' diminished synthesis and production of erythropoietin, which results in reduced bone-marrow red blood cell production. Shortened red blood cell survival, blood loss, intoxications such as lead or aluminum, and associated nutritional deficiencies may aggravate the anemia.<sup>5</sup> Two clinical trials using recombinant human