tbuckley/cabot-search huggingface dataset:
Roles Of Alpha-Beta And Gamma-Delta T-Cell Subsets In Viral Immunity
Authors: P. Doherty
Journal: Annual Review of Immunology (1992)

The current status of T-cell subset involvement in viral immunity is summarized for experimental studies in mice. The immunobiology of the normal host response is discussed, with particular reference to lymphocytic choriomeningitis (LCM) and influenza. The general impression is that CD8+ cytotoxic T lymphocytes, CD4+ TH1 cells, γ interferon, and IL-2 are of major importance, with these different components of the immune system interacting to promote an optimal response. However, experiments with a variety of virus systems indicate that there is considerable plasticity, at least in young, adult mice. Other mechanisms often compensate if a key lymphocyte subset is absent throughout the development of the immune response. Influenza-infected mice depleted of either CD4+ or CD8+ T cells clear virus and recover, though the latter may not be true for the elimination of LCM Virus. Emerging information on the involvement of γδ T cells in viral pneumonia is summarized, but there is as yet no understanding of the biological significance (if any) of these lymphocytes in viral immunity. The point is made that αβ T-cell memory to viruses is long-lived, and the need for antigen persistence to maintain such memory is questioned.
<i>Insanity and Law, A Treatise on Forensic Psychiatry.</i>By H. Douglas Singer, M. D., M. R. C. P. (London), Professor of Psychiatry, University of Illinois, College of Medicine; formerly State Alienist and Director of the State Psychopathic Institute of Illinois, and William O. Krohn, A. M., M. D., Ph. D., Author of Practical Lessons in Psychology; Head of Department of Psychology at Western Reserve University, and at the University of Illinois. (<i>Philadelphia: P. Blakiston's Son &amp; Co…
Authors: Karl A. Menninger
Journal: American Journal of Psychiatry (1929)
England and Wales in First Quarter, 1965
Journal: BMJ (1965)

England andl Wales in First QuarterThe birth rate during the first quarter of 1965 was 19.1 per 1,000, being 0.5 higher than in the preceding first quarter.The infant mortality rate at 20.9 per 1,000 live births was the lowest ever recorded in any first quarter.The death rate, 13.4 per 1,000 population, was 0.2 above the rate for the first quarter of 1964.
Incorrect Reference
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Acquisition: Blood Banking's Bugbear
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TREATMENT OF CHRONIC CATARRHAL DISEASE OF THE MIDDLE EAR BY MEANS OF INTRATUBAL INJECTIONS OF PILOCARPIN.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Leads from the MMWR. Leading major congenital malformations among minority groups in the United States, 1981-1986
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Medical Directive. A new comprehensive advance care document
Authors: L. L. Emanuel
Journal: JAMA (1989)

Living wills have been strongly endorsed in principle. Unfortunately, existing living wills are rarely used in clinical practice because they are vague and difficult to apply. To remedy this, we propose a new advance care document: the Medical Directive. The Medical Directive delineates four paradigmatic scenarios, defined by prognosis and disability of incompetent patients. In each scenario, patients are to indicate their preferences regarding specific life-sustaining interventions. The Medical Directive also provides for the designation of a proxy to make decisions in circumstances where the patient's preferences are uncertain. Finally, there is a section for a statement of wishes regarding organ donation. The Medical Directive provides an opportunity for significant improvement in the documentation of patients' preferences regarding life-sustaining care in states of incompetence. As an expression of a patient's wishes, the Medical Directive should be honored by courts and should facilitate physicianpatient discussions of critical and terminal care options. (<i>JAMA</i>. 1989;261:3288-3293)
Estimating health expenditure growth under managed competition. Science, simulations, and scenarios
Authors: R. H. Miller
Journal: JAMA (1995)

The estimated impact of health system reform proposals on health expenditures influences the health system reform debate. Health expenditure growth rate (HEGR) estimates are particularly critical because small differences in rates over time create large differences in health expenditures. There currently is no hard scientific basis for estimating the impact of managed care/managed competition legislation and market developments on the HEGR. For the 1994 health system reform debate, the two leading nonpartisan modelers developed qualitative scenarios about future health system developments in which managed care/managed competition would have little or no impact on the HEGR. We conclude that there are alternative plausible scenarios, based on current health system changes interacting with potential legislation, in which managed care/ managed competition will substantially lower the HEGR. We recommend that simulation models should provide a range of estimates that better reflect both market trends and the profound uncertainty about the effects of health system reform. (<i>JAMA</i>. 1995;273:656-662)
Crystalline Silica: Risks and Policy
Authors: Timothy S. Hardy, Hans Weill
Journal: Environmental Health Perspectives (1995)

Since the International Agency for Research on Cancer labeled crystalline silica a probable carcinogen in 1988, government regulations have required sand and other products to contain warning labels and researchers have attempted to quantitatively assess low-exposure risks. The uncertainties are unlikely to diminish any time soon, and little value exists in calculating such risks, as low exposures to this ubiquitous mineral are commonplace in both urban and rural areas due to many uncontrollable activities. What is certain is that regulatory resources targeted at continuing high-level occupational exposures would be much more likely to have beneficial public health consequences than continued attempts to assess low-exposure risks quantitatively.
Abstract 283: Redox-mediated Regulation of Histone deacetylase4, a Class II HDAC, by Thioredoxin1 through Interaction with DnaJb5, a Heat Shock Protein 40
Authors: Tetsuro Ago, Tong Liu, Hong Li, Jeffery Molkentin, Junichi Sadoshima
Journal: Circulation (2007)

Thioredoxin1 (Trx1) reduces redox-sensitive proteins and regulates cell growth and death. We previously reported that cardiac hypertrophy induced by pressure-overload is suppressed in mice with cardiac specific overexpression of Trx1 (Tg-Trx1). To elucidate the mechanisms by which Trx1 suppresses cardiac hypertrophy, we performed DNA microarray analysis using Tg-Trx1 mouse hearts. We identified DnaJb5, a heat shock protein 40, as a gene significantly upregulated by Trx1. Immunostaining and immunoblot analyses indicated that Trx1 and DnaJb5 are co-localized in the nucleus of myocytes. Pull-down and immunoprecipitation assays showed that DnaJb5 interacts with TBP-2, a Trx1-binding protein. DnaJb5 did not disturb the interaction between Trx1 and TBP-2, and enhanced the Trx1 reducing activity. Both Trx1 and DnaJb5 attenuated phenylephrine (PE)-induced activation of NFAT and myocyte hypertrophy in vitro . Using transgenic mice harboring an NFAT luciferase reporter, we confirmed that Trx1 suppresses both NFAT activation and cardiac hypertrophy induced by PE in vivo . We also found that DnaJb5 binds directly to histone deacetylase 4 (HDAC4), a class II HDAC. An HDAC4 mutant lacking the minimal region responsible for the interaction with DnaJb5 (residues 628 – 881) was localized in the cytosol, in contrast to the nuclear localization of the wild-type HDAC4, suggesting the importance of the interaction for the nuclear localization of HDAC4. Overexpression of Trx1 suppressed PE-induced nuclear export of HDAC4 in myocytes. Using mass spectroscopy, we found that HDAC4 forms a disulfide bond between Cys-667 and -669, which was reduced by Trx1. The HDAC4 Cys667/669Ser mutant was localized in the cytosol, and its nuclear export was suppressed by leptomycin B, an inhibitor of exportin, suggesting that the redox modification induces nuclear export regardless of phosphorylation. Consistently, the Cys667/669Ser substitution abolished the suppressive effect of HDAC4 on NFAT activity and cardiac hypertrophy. Collectively, these results show that Trx1 upregulates DnaJb5, which recruits HDAC4 into the complex formed by Trx1-TBP-2-DnaJb5, thereby reducing HDAC4, retaining its nuclear localization, and suppressing NFAT activity and cardiac hypertrophy.
Gender testing in the Olympics
Authors: J. L. Simpson
Journal: JAMA (1986)

Since 1968 the International Olympics Committee (IOC) has required that individuals taking part in women's sporting events present evidence of "their femininity or female gender." Competitors must report to the "Gender Verification Office," where "determination of X and Y chromatin will be conducted on a smear of buccal mucosa membrane." "If the test is inconclusive, the competitor must undergo further tests as determined by the IOC Medical Commission." Because results are not made public, the efficacy of this policy is unknown. "Gender" testing superficially strikes one as intuitively logical. That men might masquerade as women is not unthinkable in a luminous event like the Olympics. Moreover, genetic males raised as females may indeed have unfair athletic advantages as a result of increased muscle mass. An example is 5a-reductase deficiency, an autosomal recessive disorder in which 46,XY individuals are often raised as females only to virilize at puberty. As de la
Oral temperature recording in coronary care units: a risk factor
Authors: J. Olivero
Journal: JAMA (1976)

<h3>To the Editor.—</h3> I read with interest the article by Li and Ross who, as most investigators do, grouped together colon and rectal cancers for the analysis of their data and expression of their results. In addition to their use of historical controls, they expressed survival for the entire group only in terms of the stage of the disease, but not according to the site of origin of cancer within the bowel. Consideration of the site of origin within the large bowel could be of importance in treatment and prognosis. It has been suggested that for comparable stages of disease, carcinomas of the colon roughly tend to have a better prognosis than rectal lesions.<sup>1,2</sup>Some studies have suggested that radiation therapy may offer a distinct advantage of survivorship when combined with surgery for the treatment of Dukes C-stage rectal cancer,<sup>2</sup>a phenomenon presumed to be secondary to the
Fats, oil, health
Authors: Maurizio Trevisan, Jo Freudenheim, Vittorio Krogh
Journal: JAMA (1990)

<h3>In Reply. —</h3> Drs Ullmann and Connor conclude that the approximate nature of the measurements used in our study greatly weakens the conclusions. As we discuss in the article, we are fully aware of the limitations of our measurement of intake; however, this would increase the probability of type II error (ie, falsenegative results) and bias the observed association toward the null. Inaccurate measurement would not, of course, increase the observed strength of the findings.<sup>1</sup>We believe that the main reason such a "crude" measurement instrument is effective is that there is a very large variability among dietary patterns in Italy.<sup>2</sup>Ullmann and Connor dismiss as trivial the observed difference in serum cholesterol level (0.15 mmol/L) between the low- and high-consumption categories of olive oil. This group difference expressed in milligrams per deciliter is 5.8 (216.6 mg/dL for low consumers and 210.8 mg/dL for high consumers in men);
International Meeting on Hormonal Therapy of Prostatic Diseases: Basic and Clinical Aspects, Milan, Italy, May 21–24, 1986
Journal: JNCI Journal of the National Cancer Institute (1985)

International Meeting on Hormonal Therapy of Prostatic Diseases: Basic and Clinical Aspects, Milan, Italy, May 21–24, 1986 Get access JNCI: Journal of the National Cancer Institute, Volume 75, Issue 1, July 1985, Page 184, https://doi.org/10.1093/jnci/75.1.184-b Published: 01 July 1985
JAMA 75 YEARS AGO
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medical Schools in Canada
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SS. Cosmas and Damian
Authors: Zenonas Danilevicius
Journal: JAMA (1967)

The ideologic and philosophical approach to disease and cure underwent a tremendous change in the early centuries after the birth of Christ. The mythological figures were replaced by new ones; the priests and priestesses of the Aesculaepial cult were forgotten, and in their place came priests of the new religion. With the spread of Christianity, the practice of healing coincided with the ministry of the church. Deacons and priests were held in esteem, and the combined professions attracted some of the best intellects of that time. However, scientific medicine was centuries away, and experimental inquiry into the causes of disease seemed a useless and culpable undertaking. In curing diseases, one relied primarily on God's help. The influence of monotheism in medicine became evident in the teachings of Galen, who was not influenced by Christianity but by the then popular Judaic monotheism. He combined Judaism with Aristotle's philosophy and applied teleologic
Is "Bigness" the Answer?
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CRIME AND ANTI-CRIME
Journal: JAMA (1961)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Massachusetts Department of Public Health
Authors: James W. McComb
Journal: New England Journal of Medicine (1952)

LICENSING OF BLOOD BANKS REQUIRED BY NEW BLOOD-TRANSFUSION REGULATIONSThe Massachusetts Public Health Council, at its session held March 11, approved a revised set of "Rules and Regulations Relative to the Use of Blood or Other Tissues for Purposes of Transfusion." A public hearing on the draft of these rules and regulations was held on February 19, after advertisement in newspapers as required by the provisions of General Laws, Chapter 30, Section 37A, as inserted by Chapter 576 of the Acts of 1951. In further compliance with the above Act the subject rules and regulations were filed with the Secretary . . .
miR-486-3p mediates sorafenib resistance through targeting FGFR4 and EGFR in hepatocellular carcinoma
Authors: Lin Ji, Zhongjie Lin, Zhe Wan, Shunjie Xia, Shi Jiang, Dong Cen, Liuxin Cai, Junjie Xu, Xiujun Cai
Journal: Journal of Hepatology (2020)