tbuckley/cabot-search huggingface dataset:
Autologous Endothelialized Vein Allograft
Authors: Peter Lamm, Gerd Juchem, Stefan Milz, Matthias Schuffenhauer, Bruno Reichart
Journal: Circulation (2001)

Background Early graft failure after the use of less satisfactory autologous grafts (30% of all vein grafts) is caused primarily by the following problems: (1) suitable autologous transplants are limited; (2) biotechnology has not yet been able to produce reliable graft substitutes that are legally and ethically approved; and (3) current prosthetic materials are prothrombotic. To overcome these problems, we developed an easily accessible, quality-controlled graft. Methods and Results Human autologous venous endothelial cells (HAVECs) were isolated from short segments of peripheral veins unsuitable for bypass grafting. After mechanical deendothelialization of cryopreserved allograft veins (CAVs) and precoating with recipient autologous serum, these homologous cells were seeded by use of a rotating device. Growth of a confluent HAVEC layer within 1 week in a special incubator was observed. After histological and mechanical tests, 12 patients received 15 grafts in total. Bypass operation was followed by clinical and angiographic follow-up. Production period was 22±8 days. HAVEC-coated CAVs showed normal connective tissue wall structure and a tight endothelial monolayer (burst pressure &gt;2000 mm Hg). To date, 12 CABG patients lacking suitable autologous graft material have been treated. One patient died of a cause unrelated to the grafts, which were found morphologically normal and patent during autopsy. Of 15 grafts, 2 were occluded at the first angiographic follow-up. The oldest graft has now been in place for ≈3 years. Immune suppression was not administered. Conclusions At present, autologous endothelialized CAVs present good alternative small-caliber grafts for patients lacking suitable autologous vessels.
Dexamethasone alters messenger RNA levels but not synthesis of collagens, fibronectin, or laminin by cultured rat fat-storing cells
Authors: T Niki
Journal: Hepatology (1996)

Glucocorticoids have been shown to suppress collagen synthesis and gene expression by fibroblasts. However, little is known about their effects on fat-storing cells, the major matrix-producing cells in liver fibrosis. In this study we investigated the effect of dexamethasone on the extracellular matrix expression by cultured rat fat-storing cells. Fat-storing cells were isolated from male Wistar rats by collagenase/pronase digestion and purified by density gradient centrifugation. Fat-storing cells in early primary culture (3-day-old, representing a relatively quiescent phenotype) and in subculture (one passage, about 2-week-old, representing an activated phenotype) were treated with 10-6 mol/L dexamethasone for messenger RNA (mRNA) study or with 10-8 to 10-6 mol/L dexamethasone for protein study. Expression of collagen type I, III, IV, fibronectin, and laminin was analyzed at the mRNA level by Northern hybridization, and at the protein level by metabolic labeling and immunoprecipitation. Dexamethasone had a variable effect on the expression of collagen α1(I) mRNA level. While a tendency for modest suppression was observed (5%-50%) in primary cells, the difference was not statistically significant. Variable response was observed in subcultured cells. Collagen α1(III) mRNA level showed a tendency for stimulation. Dexamethasone stimulated the expression of collagen α1 (IV), fibronectin, and laminin B1 mRNA levels by 1.4-, 2.4-, and 1.6-fold respectively, in primary fat-storing cells. Subcultured cells showed a similar response, but the magnitude of stimulation was more variable than that of primary cells. Unexpectedly, at the protein level dexamethasone had no effect on the expression of these proteins. Our results indicate that glucocorticoids do not possess a net suppressive effect on extracellular matrix synthesis by fat-storing cells. Beneficial effects of glucocorticoids may be attributable to other mechanisms of action, such as their anti-inflammatory effect.
BIOLOGIC SPECIFICITY OF MITOCHONDRIA
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Handwashing and Glove Use in a Long—term-Care Facility—Maryland, 1992
Journal: JAMA (1993)

Residents of long-term-care facilities (LTCFs) are at risk for acquiring facility-associated infections and consequent mortality (1,2). Despite this risk, no national guidelines exist for infection-control practices in LTCFs, and information regarding the nature of infection-control practices in LTCFs is limited. To evaluate glove use and handwashing practices in an LTCF, and to determine factors associated with compliance with infection-control policies and the frequency of microbial transmission, Maryland Department of Health and Mental Hygiene (DHMH) and CDC staff observed glove use and handwashing practices on a chronic-care ward of an LTCF in Maryland for a 1-month period during 1992. This report summarizes the findings of this study.
Recent Advances in Medicine, Clinical, Laboratory, Therapeutic.
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A definition for community-based surveillance and a way forward: results of the WHO global technical meeting, France, 26 to 28 June 2018
Journal: Eurosurveillance (2019)

Preview this article: A definition for community-based surveillance and a way forward: results of the WHO global technical meeting, France, 26 to 28 June 2018, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/24/2/eurosurv-24-2-5-1.gif
'A modern view of the surgical treatment of peripheral arterial disease'. A critical response
Authors: C. Mankowitz
Journal: JAMA (1979)

MILLER and Griepp<sup>1</sup>presented a lucid description of the current state of the art in the surgery of peripheral vascular disease. Because of the authoritative nature of such an article, we believe that it is important to present a different point of view. The authors have fallen prey to two fallacies—one fairly subtle, the other a more usual type. In the first instance, they convey the impression that the peripheral arteries are all equivalent. Methods of diagnosis and treatment that work for one should work for all. This ignores the exceedingly important differences between the structures and organs those arteries supply. The brain, which is supplied by the carotid and vertebrobasilar arteries, is totally different in its function and importance from either the foot or any of the viscera. In our opinion, transposing surgical methods that may be effective in preventing gangrene of the foot to the extracerebral vasculature
Differential diagnosis of RSR' and dominant R wave patterns in right chest leads
Authors: M. M. Menendez
Journal: JAMA (1966)

Dominant R waves or RSR' patterns in right precordial leads frequently present problems in differential diagnosis. Either may be a normal variant or an indication of heart disease. <h3>RSR' Variants</h3> Variants of the RSR' pattern are common in normal children and not uncommon in young adults. The normal R' wave is attributed to late activation of the crista supraventricularis. It is often difficult to distinguish normal from abnormal and one of the knottiest problems is the RSR' complex in lead V<sub>1</sub>or V<sub>2</sub>that casts suspicion on the otherwise normal patient and her tracing (Figure,<i>d</i>). Some general rules are helpful:<sup>1</sup> An R' wave is probably normal in V2 if it is not found in V1; it is probably normal in V1 if not present in V3R or a low V1. An R' wave is probably abnormal if it is associated with a primary R
BELGIUM
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Comparison of oral treatment with zinc sulphate and placebo in acne vulgaris
Authors: LARS HILLSTROM, LARS PETTERSSON, LENNART HELLBE, ALVA KJELLIN, CARL-GUSTAF LECZINSKY, CHRISTER NORDWALL
Journal: British Journal of Dermatology (1977)

Journal Article Comparison of oral treatment with zinc sulphate and placebo in acne vulgaris Get access LARS HILLSTROM, LARS HILLSTROM Department of Dermatology, District General Hospital Gavle, Sweden Dr Lars Hillstrom, Department of Dermatology, District General Hospital, S‐800 07 GAVLE Sweden. Search for other works by this author on: Oxford Academic Google Scholar LARS PETTERSSON, LARS PETTERSSON Department of Dermatology, District General Hospital Gavle, Sweden Search for other works by this author on: Oxford Academic Google Scholar LENNART HELLBE, LENNART HELLBE Department of Dermatology, Central County Hospital, Orebro, Sweden Search for other works by this author on: Oxford Academic Google Scholar ALVA KJELLIN, ALVA KJELLIN Department of Dermatology, District General Hospital Boden, Sweden Search for other works by this author on: Oxford Academic Google Scholar CARL‐GUSTAF LECZINSKY, CARL‐GUSTAF LECZINSKY Department of Dermatology, District General Hospital Boras, Sweden Search for other works by this author on: Oxford Academic Google Scholar CHRISTER NORDWALL CHRISTER NORDWALL Department of Dermatology, District General Hospital Karlstad, Sweden Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 97, Issue 6, 1 December 1977, Pages 679–684, https://doi.org/10.1111/j.1365-2133.1977.tb14276.x Published: 01 December 1977
Substance use and abuse
Authors: Jérôme Pugin, Peter M. Suter
Journal: JAMA (1991)

<h3>In Reply.</h3> —Poole et al correctly point out the fact that in our study as well as in other reports on selective decontamination of the aerodigestive tract (SDA), no reduction of hospital mortality was observed in the treatment patients compared with controls, despite significant reduction of ventilator-associated pneumonia by SDA. This is effectively a crucial point, but may have other explanations than those proposed by Poole et al. First, when a difference is statistically not significant, like in-hospital mortality in our two groups, this can be due to the lack of efficacy of the SDA regimen or an insufficient number of subjects randomized into the two groups. Increased mortality due to the development of ventilator-associated pneumonia can be estimated at 10% to 15%. As stated in the discussion of our article, more than 700 patients would be necessary to be included in a randomized study to have a sufficient power
IgA triggers tumor necrosis factor α secretion by monocytes: A study in normal subjects and patients with alcoholic cirrhosis
Authors: J Devière
Journal: Hepatology (1991)

Under endotoxin-free conditions, peripheral blood mononuclear cells and purified monocytes isolated from healthy control subjects and patients with alcoholic cirrhosis disclose elevated tumor necrosis factor α messenger RNA level and produce tumor necrosis factor α in response to stimulation by either soluble polymeric IgA or monomeric IgA bound to the surface of culture dishes but not by soluble monomeric IgA. Polymeric IgA induces tumor necrosis factor α secretion in a dose-dependent fashion. These results suggest that cross-linking of Fcα receptors on human monocytes induces the messenger RNA accumulation and the secretion of the cytotoxic and immunoregulatory cytokine tumor necrosis factor α. Furthermore, it is shown that lipopolysaccharide-induced tumor necrosis factor α secretion by peripheral blood mononuclear cells is synergistically enhanced in the presence of solid phase monomeric IgA but not in the presence of either soluble monomeric or polymeric IgA. Although increased lipopolysaccharide-induced tumor necrosis factor α secretion is observed at baseline in alcoholic cirrhotic patients, this synergism is also expressed in this group of patients. These observations could be of pathophysiological relevance in alcoholic cirrhosis because monomeric IgA deposits along the liver sinusoids and increased serum levels of polymeric IgA are common even in the early stages of this disease. (HEPATOLOGY 1991;13:670–675.)
CACTUS GRANDIFLORUS.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Canine Zoonoses
Authors: George L. Fite
Journal: JAMA (1975)

Man's major pet, the dog, has been bred as such for several thousand years. However variable the sizes and appearances, the many breeds, including the now wild varieties such as the Australian dingo, all belong to a single species. Perhaps a major factor in the dog's survival in association with man has been his relative immunity to human bacterial, parasitic, and viral diseases. But the dog is troubled with susceptibility to several diseases of his own, including a severely destructive hepatitis, the virus of which, fortunately, does not infect man. The dog's distemper won't bother his keeper. Yet he does have diseases that he may give to his owner, directly or indirectly. Undoubtedly, most damage is done by his biting a known 600,000 people a year, with minor bites perhaps tripling that figure. Undoubtedly, too, the dog's feral habit of being willing to bite almost any animal (and be bitten
Factors affecting bone mass
Authors: H. Rico
Journal: JAMA (1994)

<h3>In Reply.</h3> —As Drs Rico and Revilla note, the sample of women who were breast-feeding lost in excess of 5% at the lumbar spine and femoral neck. They propose that seasonal variation and weight loss following parturition are viable explanations for the loss rather than breast-feeding. Seasonal variation in sunlight exposure has been observed with seasonal variation in serum vitamin D levels for some time.<sup>1,2</sup>This seasonal variation might be associated with bone mass loss under conditions of pregnancy and lactation in absence of a source of vitamin D from sunlight or diet. Several factors argue against seasonal variation in vitamin D as a source of explanation of the observed bone loss in the group with extended lactation. First, the lactating women were compared with controls who had also experienced a pregnancy. Those controls did not experience the transient bone loss of the lactating women. Second, the lactating women
The Murderers
Authors: Dale G. Friend
Journal: JAMA (1962)

This book, essentially a story of the law enforcement of the Harrison Narcotic Act, makes most interesting reading. The material, selected from the files of the Federal Narcotic Bureau, covers the entire span of the Bureau's activities. Unquestionably, the authors have shown the importance of a powerful regulatory and police system as far as the narcotic drug trade is concerned. In reading the book, one is impressed by the heroism, faithfulness to duty, and high risks exhibited by enforcement officers. It is apparent to the reviewer that there exists a continuing need for strong legal regulations and strict law enforcement of violations of the Harrison Narcotic Act. If these laws were weakened, it would undoubtedly lead to an increase in the illegal narcotic racket. The problem that disturbs serious thinking medical people is the fact that individual patients caught in the web of narcotic addiction are indeed pathetic. They have
THE HOUSE OF DELEGATES.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Preexisting conditions 'hold Americans hostage' to employers and insurance
Authors: P. Cotton
Journal: JAMA (1991)

"MILLIONS OF hardworking, honest Americans are being held hostage by insurance companies. I am one of them." So begins a letter to President George Bush from Mary Evans, a Columbus, Ohio, woman with an increasingly common tale to tell: Savings wiped out after payment denials for treatment of preexisting conditions (in Evans' case, surgery to remove breast cancer that her insurer says she "should have" found before she had to switch policies because of her husband's job change); Fear that recurrence would require a bone marrow transplant she could not afford if her insurance would not pay; Disgust with what Evans calls the "mountain of paperwork" and "snippy, haughty, surly" treatment from insurance companies; No apparent way out. If she dared to change insurers, a new policy would almost surely exclude cancer coverage. "If you have the misfortune of getting a catastrophic illness, you are literally held hostage by the
Dealing with residual bile duct stones.
Authors: R W Motson
Journal: BMJ (1979)

capsid antigen.The IgM titre was screened routinely at 1/8 but no further dilutions were assayed.The discrepancy in the titres re- ported from Manchester and Colindale on roughly contemporaneous samples can only be attributed to methodological differences.Antibodies to cytomegalovirus were de- tected in the laboratory of Professor Harold Stern, St George's Hospital Medical School, using complement fixation as stated in our article.Numerous attempts were made to isolate this virus from the patient's urine but without success.Because of limitations of space, we could only summarise the serological data in our article and we could not fully discuss the diagnostic possibilities.We agree that one cannot be dogmatic about the nature of this patient's illness.It is our belief that the most likely explanation is that she had a primary infection with EB virus to which she was unable to make an adequate immunological response.Indeed, the antibody titres to cyto- megalovirus may be attributable to cross- reaction of antibody between this virus and EB virus.'However, we agree that we cannot exclude the possibility that this patient had a double infection with both viruses and that the impaired response to EB virus reflects the immunosuppression induced by cytomegalovirus.