tbuckley/cabot-search huggingface dataset:
Pulmonary Medicine
Authors: Harry B. Greenberg
Journal: JAMA (1977)

Understanding the results of blood gas analyses and other tests of pulmonary function is becoming a necessity for almost every physician who has to treat his patients in a hospital. The first five chapters of<i>Pulmonary Medicine</i>can show him how to interpret these tests, if not on his first reading of the book, then on his second or third. The eight contributors to<i>Pulmonary Medicine</i>also tell him how to recognize and treat asthma, pneumonia, tuberculosis, and other diseases and how and when to use mechanical ventilators. Mechanical ventilatory support is a last resort in the management of status asthmaticus, according to Welch, who emphasizes the need for high inspiratory pressures and slow rates. His discussions of asthma include immunotherapy, methyl xanthine and sympathomimetic bronchodilator drugs, and aerosolized corticosteroids. He finds cromolyn sodium useful for the hard-to-manage patient and questions the value of mucolytic enzymes. Mucociliary clearance mechanisms cannot
Acute Hepatitis and Renal Failure Following Ingestion of Raw Carp Gallbladders-Maryland and Pennsylvania, 1991 and 1994
Journal: JAMA (1995)

In some cultures, eating gallbladders from certain species of snakes, birds, or fish is believed to improve health. A syndrome of acute hepatitis and renal failure following the ingestion of raw carp gallbladders has been described previously among persons living in Asia (1-4). This report summarizes two cases of this syndrome that occurred in residents of Pennsylvania who had eaten the raw bile and gallbladders of carp caught in Maryland.
Erratum
Journal: Allergy (2005)

AllergyVolume 60, Issue 4 p. 548-548 Free Access Erratum First published: 23 February 2005 https://doi.org/10.1111/j.1398-9995.2005.00838.xAboutSectionsPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat In (1), the following error was published on page 33. S. Bonini, V. Brusasco, K.-H. Carlsen, L. Delgado, S. D. Giacco, T. Haahtela, G. Rasi, P. B. Cauwenberge The author listing was wrong and should have read: S. Bonini, V. Brusasco, K.-H. Carlsen, L. Delgado, S. R. Del Giacco, T. Haahtela, G. Rasi, P. B. Cauwenberge We apologise for this error. Reference 1 Bonini S, Brusasco V, Carlsen K-H, Delgado L, Giacco SD, Haahtela T et al. Diagnosis of asthma and permitted use of inhaled β2-agonists in athletes. Allergy 2004; 59: 33– 36. Wiley Online LibraryCASPubMedWeb of Science®Google Scholar Volume60, Issue4April 2005Pages 548-548 ReferencesRelatedInformation
Deaths
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Harvesting
Authors: W. Blair Brooks
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Two Centuries Earlier
Journal: JAMA (1974)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Support Loan Deferment Now
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SODIUM VERSUS POTASSIUM
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Chest pain duration in myocardial infarction
Authors: J. R. Ledwich
Journal: JAMA (1980)

Routine clinical and laboratory data were collected from 70 patients with first myocardial infarcts. Compared with the 35 patients whose chest pain duration was less than eight hours, those with chest pain eight hours or longer had higher rises in creatine phosphokinase and SGOT levels, greater summed ST segments (taken from the 12-lead ECG), more transmural infarcts, greater cardiac volumes (measured from subsequent chest roentgenograms), higher temperature rises, and higher WBC counts. These results suggest that pain duration may be an indicator of infarct size. (<i>JAMA</i>244:2172-2174, 1980)
The Gravedigger
Authors: James S Goodwin
Journal: Annals of Internal Medicine (2011)

On Being a Doctor20 September 2011The GravediggerJames S. Goodwin, MDJames S. Goodwin, MDFrom The University of Texas Medical Branch, Galveston, TX 77555-0177.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-155-6-201109200-00012 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail I go to my patients' funerals whenever possible. It is a way of showing respect for the patient and the patient's family. Depending on the denomination, a funeral also provides me with 1-, 2-, or 3-hour periods to sit and think. My funeral thoughts relate to the big issues of life and death, and I come away with a feeling of peace and of being part of a community.Nothing in these funeral-going experiences prepared me for gravedigging, however. Digging a grave is like a funeral, raised to the tenth power.The call came at about 2:00 a.m. on a ... Author, Article, and Disclosure InformationAffiliations: From The University of Texas Medical Branch, Galveston, TX 77555-0177.Corresponding Author: James S. Goodwin, MD, Department of Internal Medicine, Sealy Center on Aging, The University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-0177; e-mail, [email protected]edu. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 20 September 2011Volume 155, Issue 6Page: 398-399KeywordsAgingAnxietyBrainEmotionsFoodMemorySuicideSweat ePublished: 20 September 2011 Issue Published: 20 September 2011 Copyright & PermissionsCopyright © 2011 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
O6.01 * TARGETING THE IMMUNE CHECKPOINT NETWORK WITH MIR-138 EXERTS THERAPEUTIC EFFICACY IN MURINE MODELS OF GLIOMA
Authors: A. Heimberger, J. Wei, E. Nduom, L. Kong, C. Ivan, G. N. Fuller, M. R. Gilbert, C. A. Conrad, G. A. Calin
Journal: Neuro-Oncology (2014)

Antibody therapeutic targeting of the immune checkpoints CTLA-4 and PD-1 has demonstrated marked tumor regression in clinical trials; however, this requires multimodality treatment and has known toxicity. Furthermore, the targeting of one checkpoint often results in the up-regulation of another. MicroRNAs (miRNAs) can modulate gene transcripts, including those of tumor-mediated immune suppressive pathways and networks. Additionally, miRNAs can be delivered to the systemic immune compartment, which can initiate anti-tumor immune response, including within the central nervous system, thereby overcoming the confounding issue of miRNA delivery to the tumor. To identify potential immune modulatory miRNA therapeutics, we exploited human glioblastoma miRNA expression assays followed by a screening process of predicted binding sites in the 3' UTR of immune suppressive pathways and immune checkpoints. MiR-138 emerged as a leading candidate with three predicted binding sites in the 3' UTR of CTLA-4 and one within PD-1, which was functionally confirmed with luciferase expression assays. The miR-138 targeting of CTLA-4 and PD-1 was further validated by expression analysis of transfected human CD4+ T cells. Using human glioma tumor microarrays and in situ hybridization, heterogeneous expression of miR-138 was found amongst all glioma grades and pathological subtypes. The PD-1 ligand, PD-L1, was frequently expressed in glioblastomas based on immunohistochemistry and ex vivo flow cytometry from fresh human glioblastoma. Analysis of TCGA database revealed that co-expression of PD-1 and PD-L1 impacts glioblastoma survival. Given the previously documented role of CTLA-4 as an operational mechanism of glioblastoma-mediated immune suppression, this cumulative data suggests that dual targeting of CTLA-4 and PD-1 with miR-138 in glioblastoma patients may have anti-tumor activity. In vivo treatment with miR-138 in immune-competent mice with GL261 gliomas demonstrated marked tumor regression, a 43% increase in median survival (P = 0.011), and an associated decrease in intratumoral FoxP3+ Tregs, CTLA-4, and PD-1 expression. Conversely, in an immune-incompetent animal background, miR-138 failed to exert any therapeutic effect, indicating that miR-138 mediates in vivo activity via the immune system. Cumulatively, our data indicate that miR-138 may be an active and novel immunotherapeutic agent for human glioblastoma patients.
Perforation of gloves.
Authors: P. S. Wong, J. E. Wright, P. A. White
Journal: BMJ (1992)

In common with many other cell types, synovial fibroblasts produce exosomes. In this study, we show that the exosomes produced by synovial fibroblasts obtained from individuals with rheumatoid arthritis (RASF), but not exosomes produced by synovial fibroblasts obtained from individuals with osteoarthritis, contain a membrane bound form of TNF-α as demonstrated by colloidal gold immunostaining of TNF-α and confirmed by both Western blot and mass spectrometry. The RASF-derived exosomes, but not exosomes derived from fibroblasts obtained from individuals with osteoarthritis, are cytotoxic for the L929 cell, a TNF-α-sensitive cell line, and stimulate activation of NF-κB and induction of collagenase-1 in RASF. These effects are blocked by addition of soluble TNFR1 (sTNFbp), suggesting that a TNF-α-signaling pathway mediates these biological activities. sTNFbp also reduced the production of exosomes by RASF, suggesting the interruption of a positive amplification loop. Exosomes can transmit signals between cells, and RASF exosomes, effectively taken up by anti-CD3-activated T cells, activated AKT and NF-κB and rendered these activated T cells resistant to apoptosis. Neutralization of exosomal membrane TNF-α by sTNFbp partially reversed this resistance, suggesting that not only TNF-α but also additional exosomal proteins may contribute to the development of apoptosis resistance.
A phase III trial comparing FULV to FULV + oxaliplatin in stage II or III carcinoma of the colon: Survival results of NSABP Protocol C-07
Authors: N. Wolmark, S. Wieand, P. J. Kuebler, L. Colangelo, M. J. O'Connell, G. Yothers
Journal: Journal of Clinical Oncology (2008)

LBA4005 Background: We previously reported that FULV + oxaliplatin (FLOX) significantly prolonged 3-year disease-free survival when compared to FULV (ASCO 2005; J Clin Oncol 2007) A secondary end point of this study was overall survival (S) at five years; the data are presented herein. Methods: Between February 2000 and November 2002, 2,409 eligible patients with follow-up (1209 FULV and 1200 FLOX) with stage II (28.9%) or III carcinoma of the colon were randomized to receive either FULV (5-FU, 500 mg/m2 iv bolus weekly×6; LV, 500 mg/m2 iv weekly×6, each 8 week cycle×3) or FLOX (same FULV regimen with oxaliplatin 85 mg/m2 iv administered on weeks 1, 3, and 5 of each 8 week cycle×3). A planned secondary end point of this study was overall survival 5 years after the completion of accrual. The hazard ratio estimate is from a Cox model stratified by positive nodes (0, 1–3, 4+). The p-value is from a log-rank test stratified by positive nodes. Results: The median follow-up for patients who were still alive was 67 months; 75% had at least 5-years of follow-up. Because the number of deaths (560) was fewer than anticipated (700), the power to detect the protocol specified effect size of a 0.214 reduction in the annual death rate was reduced from 0.89 to 0.81. The hazard ratio (FLOX vs. FULV) was 0.853 with 95% CI (0.723, 1.008), a 14.7% reduction in the risk of death in favor of FLOX. Conclusions: There is a trend toward improved survival with the addition of oxaliplatin to weekly FULV (p=0.061) in patients with Stage II and III colon cancer with 67 months median follow-up. Overall, there were fewer deaths than had been anticipated. 5 yr survival N Deaths % S P FULV 1209 301 78.3 0.061 FLOX 1200 259 80.3 Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Expert Testimony Other Remuneration sanofi-aventis
Book Review Clinical Pellagra . By Seale Harris, M.D., assisted by Seale Harris, Jr., M.D. With a foreword by E. V. McCollum, Ph.D., Sc.D., LL.D. 4°, cloth, 494 pp., with 66 illustrations, and 4 color plates. St. Louis: The C. V. Mosby Company, 1941. $7.00.
Journal: New England Journal of Medicine (1941)
A CLAIM OF PRIORITY. ATTEMPT TO COMMUNICATE ARTIFICIAL IMMUNITY.
Authors: ALBERT S. ASHMEAD
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Incorrect Terms
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Highly Sensitive and Wearable Liquid Metal‐Based Pressure Sensor for Health Monitoring Applications: Integration of a 3D‐Printed Microbump Array with the Microchannel
Authors: Kyuyoung Kim, Jungrak Choi, Yongrok Jeong, Incheol Cho, Minseong Kim, Seunghwan Kim, Yongsuk Oh, Inkyu Park
Journal: Advanced Healthcare Materials (2020)

Adv. Healthcare Mater. 2019, 8, 1900978 In the original version of this article, the author name Yongsuk Oh was incorrect. The correct author name is Yong Suk Oh. The editors apologize for any confusion caused.
ECTOPIA TESTICULI.
Authors: JNO. MADDEN
Journal: JAMA (1895)

The drawings herewith submitted are to illustrate a case of, and an operation for the excision of an ectopic testicle, made by the author on March 4 of the present year. The patient is a young man, 22 years old. Four or five years ago he first noticed a bulging at the left external abdominal ring which was accompanied by a dull pain extending to the loins and back. For one, two or three weeks the bulging would disappear, during which time he felt no discomfort. An examination of the part while the tumor was present, disclosed only the presence of a mass of soft tissue in the inguinal canal, in the midst of which could be felt a cord which was taken to be the spermatic cord. The conclusion was therefore reached that the testicle was within the abdomen, its descent prevented by the smallness of the internal abdominal
The Cover
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal