tbuckley/cabot-search huggingface dataset:
The Beat-Transfer: A Verbal Correction
Journal: BMJ (1894)

JOURNALISTS AND QUACKS.AFTER the Review of Reviews, the Daily News, after Mattei, Gatchkowsky.If the irresponsible, unblushing, and most mischievous patronage of the wildest and most senseless form of quackery were not nowadays so frequent in British journalism, the insertion of such an editorial paragraph as the subjoined in a journal of weight and standing, and enjoying a well-deserved political and literary reputation, would be incredible and impossible.But no excess of fatuous absurdity and no extremity of self-evident ignorance are beyond the credulity of the political journalist of to-day.Nevertheless, it was not without regret that we read in the Daily News of this week the subjoined editorial paragraph, which embodies, perhaps, as much impudent and mis- leading and extravagant pretension as any in the annals even of mediaeval darkness.The italics are ours." ' Vitaline,' a Cure for Consumption.-Abouteight years ago M. Gatch- kowsky, a Polish amateur chemist, struck, in the course of his medical studies, with the remarkable cures effected by the Chinese doctors, deter- mined to turn his energies in that direction, and, after a long series of experiments, succeeded in obtaining, as a result of an admixture of borax and glycerine (!), a compound for which the most extraordinary virtues are claimed.After elaborate analysis on the part of numerous celebrated (?) French doctors, 'Vitaline'-such being the name given by M. Gatch-
Efficacy and Safety of Regimens Used for the Treatment of POEMS Syndrome- a Systematic Review
Authors: Unaiza Faizan, Muhammad Saad Farooqi, Hassaan Imtiaz, Muhammad Yasir Anwar, Muhammad Khawar Sana, Arafat Ali Farooqui, Zahoor Ahmed, Abdul Jabbar Dar, Hamza Hashmi, Faiz Anwer
Journal: Blood (2020)
Anaphylaxis to cephaloridine in a nurse who prepared solutions of the drug
Authors: K. Kaplan
Journal: JAMA (1967)

Cephalothinand cephaloridine, semisynthetic derivatives of 7-amino-cephalosporanic acid, have been used extensively for the successful management of infections produced by staphylococci sensitive and resistant to penicillin G, other gram-positive organisms, and some species of gram-negative bacteria.<sup>1-5</sup>These agents have frequently been employed when penicillin allergy has been present. Although a lack of cross-reaction between these classes of antibiotics has been noted by some investigators, others have described instances in which cross-allergenicity appeared to be present.<sup>3,6</sup>Since the cephalosporin derivatives may themselves induce hypersensitivity, it may be difficult or impossible to prove that a reaction developing during their administration to penicillin-sensitized individuals is indicative of cross-reactivity. This is especially so if the untoward effect does not appear until the third or fourth day of therapy or later. A reaction developing after the first dose of either type of agent in a person known to be sensitive to one is
PATHOLOGIC LESIONS IN INSANITY.
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bureau of Investigation
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Kanfer Neuromuscular or Handwriting Test
Journal: CA A Cancer Journal for Clinicians (1971)

Tile follou'ing ste tern en WaS recently (listributed to the 58 Divisions of tile A ni erican Cancei-Societij fm their intiiinat loifl.Kanfer Neuromuscularor Handwriting Test After careful study of the literature and other information available to it, the American Cancer Society does not have evidence that the Kanfer Neuro muscular or Handwriting Test is a proven means of diagnosing cancer.The following is a summary of in formation on the Kanfer Neuromus cular or Handwriting Test in the American Cancer Society files: Test Alfred Kanfer's interest in hand writing characteristics as a means of detecting cancer began while he was a young handwriting consultant to the Austrian Department of Justice.In 1934, he obtained permission from the Health Commissioner of Vienna to do research at the city hospital there.In
BERI-BERI IN THE GRAND BANKS FISHING FLEET.
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SAT0012 C-reactive protein: not only a marker, but also a cause of inflammation through metabolic reprogramming of human macrophages
Authors: M. Newling, L. Sritharan, B. Everts, L. de Boer, S. Zaat, D. Baeten, J. den Dunnen
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> C-reactive protein (CRP) is an acute-phase protein produced in high quantities by the liver in response to infection and during chronic inflammatory disorders such as rheumatoid arthritis (RA). As a consequence, CRP is in widespread clinical use as a general marker of inflammation. Although CRP is known to facilitate clearance of cell debris by phagocytic cells by binding to its ligand phosphocholine on dead cells, additional functions of CRP are still not completely understood. <h3>Objectives</h3> Here, we set out to investigate whether CRP, which is present in high concentrations in synovial fluid of active RA patients, also plays a role in the orchestration of inflammation in the inflamed joint. <h3>Methods</h3> Human macrophages were differentiated from blood monocytes of healthy volunteers. Cells were stimulated with complexed CRP (c-CRP) and/or ligands for Toll-like receptors (TLRs), mimicking the stimuli in the inflamed joint. Responsible signalling pathways were identified using small molecule inhibitors and RNA interference. Metabolic pathways were identified using specific inhibitors and the Seahorse metabolic analyzer. <h3>Results</h3> Strikingly, we here provide evidence that CRP is not only a marker, but also a cause of inflammation by strongly amplifying the production of RA-associated pro-inflammatory cytokines. We show that complex formation of CRP as a result of binding to its ligand phosphocholine selectively enhanced TNFα, IL-1β, and IL-23 production by human macrophages. While c-CRP did not induce cytokine production individually, c-CRP synergized with TLRs to amplify cytokine gene translation. We identified Fc gamma receptor I and IIa (FcγRI and FcγRIIa) as the main receptors responsible. Moreover, we unravelled the responsible molecular mechanism of c-CRP-induced inflammation, which crucially depends on signalling through kinases Syk and PI3K, resulting in enhanced gene translation of pro-inflammatory cytokines through metabolic reprogramming, particularly through amplified glycolysis and fatty acid synthesis. <h3>Conclusions</h3> These data indicate that CRP is not only a marker, but might also be a cause of inflammation in RA patients by selectively promoting RA-associated pro-inflammatory cytokine production by human macrophages, thereby exacerbating pathology. From a therapeutic point of view, inhibition of c-CRP-induced immune activation, e.g. by targeting the identified molecular mechanisms, may be a valuable tool to suppress inflammation. <h3>Disclosure of Interest</h3> M. Newling: None declared, L. Sritharan: None declared, B. Everts: None declared, L. de Boer: None declared, S. Zaat: None declared, D. Baeten Employee of: Union Chimique Belge, J. den Dunnen: None declared
Experimental Pyelonephritis in the Alloxan-Diabetic Animal
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Geriatrics
Authors: Knight Steel
Journal: JAMA (1985)

Geriatric medicine, although nebulous by tradition, is gaining form and structure as its importance is recognized by academic, professional, and governmental organizations. During the very recent past, the scientific base of geriatrics has expanded to include investigation of such conditions as hypertension, which affect both the elderly and individuals of middle age. In addition, researchers have begun to address the early control of risk factors for diseases that become manifest in later years. Geriatric medicine is increasingly being recognized as integral to the entire spectrum of adult medicine; educational material is being integrated into the medical school curriculum and the continuing medical education efforts of some specialities.<sup>1</sup>Guidelines for the teaching of geriatric medicine have been adopted by the American Academy of Family Physicians,<sup>2</sup>and the means for recognizing special competence in geriatric medicine are under consideration by the American Board of Internal Medicine and the American Board
Trio Wins Nobel for Hypoxia Discoveries
Journal: Cancer Discovery (2019)

Abstract William G. Kaelin Jr., MD; Sir Peter J. Ratcliffe, MD; and Gregg L. Semenza, MD, PhD, won this year's Nobel Prize in Physiology or Medicine for their research elucidating how cells sense and adapt to oxygen levels–work that not only is fundamental to biology, but also has clinical applications for a range of diseases, including cancer.
Contents
Authors: David Wallace, Reena Fotedar, Paul Mitchell, George Burlutsky, Jin Wang, Kathryn Rose, Ian Morgan, Jenny Ip, Annette Kifley, Son Huynh, Wayne Smith, Mingguang He, Wenyong Huang, Yingfeng Zheng, Helge Alsbirk, Paul Med, Barry Schechter, Aaleya Koreishi, Carol Karp, William Feuer, Amber Sturges, Amir Butt, James Lai, James Chodosh, Sonia Yoo, George Kymionis, Takeshi Ide, David Goldman, Terrence O'brien, William Culbertson, Eduardo Alfonso, Thomas Kohnen, Ekkehard Fabian, Ralf Gerl, Wilfried Hunold, Werner Hu ¨tz, ¨rgen Strobel, Heike Hoyer, Ulrich Mester, Joshua Stein, Padmaja Ayyagari, Frank Sloan, David Friedman, Steven Hahn, Laurie Gelb, Jason Tan, Sonali Shah, Elizabeth Kim, Thom Zimmerman, Yu-Wen Lan, I-Jong Wang, Jui-Ling Liu, Ching-Yu Cheng, Wen-Ming Hsu, Felipe Medeiros, Gianmarco Vizzeri, Linda Zangwill, Luciana Alencar, Pamela Sample, Robert Weinreb, Carol Yim, Lui Cheung, Christopher Kai, Shun Leung, Dusheung Lin, Chi-Pui Pang, Dennis Dphil, Chiu Shun
Journal: Ophthalmology (2008)
Miscellany
Journal: JAMA (1933)

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OFFICIALS OF THE ASSOCIATION
Journal: JAMA (1969)

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Diabolites
Authors: Samuel Vaisrub
Journal: JAMA (1976)

We are taught that metabolism comprises anabolism and catabolism. What the texts neglect to mention is diabolism, a set of processes that are doubtless manifestations of diabolic intent. Some of these processes fit into the category of "inborn errors" of metabolism, with their display of gargoyles and monsters. Others, less obvious, create mischief so as to frustrate the clinician and the investigator when they least expect it. The mediators of diabolism are diabolites, who dwell in the body's "Satanic mills." Unlike metabolites, they do not lend themselves readily to chemical analysis. For instance, years of intensive investigation have failed to identify the diabolite responsible for weight gain after a prolonged starvation diet. Alternately labeled "obesolase" and "adiposozyme," the mischievous diabolite continues to elude identification, although there are some indications that it may be a polypeptide with a mysterious side-chain that converts inhaled pollutants to fat. Known to some as "dysbalance-ase,"
Yersinia hepatic abscesses subsequent to long-term iron therapy
Authors: P. M. Leighton
Journal: JAMA (1987)

A 71-year-old woman who had been receiving iron injections for at least ten years was admitted to the Dr Everett Chalmers Hospital, Fredericton, New Brunswick. The initial diagnosis was metastatic tumors in the liver, but after further evaluation, the initial diagnosis was corrected to multiple hepatic abscesses due to<i>Yersinia enterocolitica</i>. The liver biopsy showed abundant iron deposition. With the appropriate antibiotic treatment, the patient recovered. (<i>JAMA</i>1987;257:964-965)
Errors in Abstract, Text, and Figure 1 and Addition of Open Access
Authors: João Ferreira, Nicolas Girerd, Faiez Zannad
Journal: JAMA Cardiology (2018)

Seamus C. Harrison, PhD, FRCS; Michael V. Holmes, MD, PhD; Stephen Burgess, PhD; Folkert W. Asselbergs, MD, PhD; Gregory T. Jones, PhD; Annette F. Baas, MD, PhD; F. N. van ’t Hof, MD; Paul I. W. de Bakker, PhD; Jan D. Blankensteijn, MD, PhD; Janet T. Powell, PhD, FRCPath; Athanasios Saratzis, PhD, MRCS; Gert J. de Borst, MD, PhD; Daniel I. Swerdlow, PhD; Yolanda van der Graaf, MD, PhD; Andre M. van Rij, MD, PhD; David J. Carey, PhD; James R. Elmore, MD; Gerard Tromp, PhD; Helena Kuivaniemi, MD, PhD; Robert D. Sayers, MD, FRCS; Nilesh J. Samani, FRCP; Matthew J. Bown, MD, FRCS; Steve E. Humphries, PhD
Congenital Zika Virus Infection
Authors: Adriana Suely de Oliveira Melo, Leila Chimelli, Amilcar Tanuri
Journal: JAMA Neurology (2017)

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SOCIETY PROCEEDINGS.
Authors: W. H. H. Githens
Journal: JAMA (1884)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TINCTURE OF DIGITALIS AND THE INFUSION IN THERAPEUTICS
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal