tbuckley/cabot-search huggingface dataset:
How Is Your Heart? Intimate Talks on the Prevention of Heart Disease and on the Care of an Already Damaged Heart.
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Accredited Institutions or Organizations for Continuing Medical Education
Journal: JAMA (1980)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Editorial: Abdominal cysts.
Journal: BMJ (1973)

number, and displacement of the inferior thyroid artery.None of these are specific to the condition.Venous sampling from catheterization of the thyroid venous bed usually shows raised levels of calcitonin and parathyroid hormone on both sides of the neck, higher values -being obtained than in the peripheral circulation.Sampling in this way does not appear to have much value in diagnosis, which is more easily achieved by peripheral sling for calcitonin with or without calcium infusion.5The characteristic radiological features of the familial syn- drome can be of help in the diagnosis of this thyroid tumour and complement the more specific histological and hormonal abnormalities.
Caring for the chronically mentally ill
Authors: R. L. Martensen
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Gastrointestinal problems in the old. I.
Authors: D E Hyams
Journal: BMJ (1974)

Gastrointestinal symptoms and diseases increase with ageing, and the commonest lesions are carcinoma (of the stomach or large bowel), peptic ulceration, intestinal obstruction (herniae or diverticular disease of the colon), hiatus hernia, and gallstones.The first three of these caused most of the 20% of deaths directly due to lesions of the digestive system in Mc- Keown's series of 1,500 necropsies in patients aged 70 or over."This incidence was second only to diseases of the cardiovascular system as causes of death, and numerically only a little less.Carcinomas of the gastrointestinal system made up nearly half of the total of fatal malignant disease, and half of these were in the large bowel.Disease of the biliary tract has been said to be the commonest pathological finding requiring abdominal sur- gery in the aged.2In elderly patients with abdominal pain, Ponka et al. found that gallbladder disease was the cause in 27-5%.3Functional Changes in the Gut Changes have been described in the flow and composition of saliva, gastric juice, bile, and pancreatic juice; in the motility of the stomach and large bowel; in small intestinal absorption; and in large bowel flora.Associated structural changes have also been described.It is doubtful, however, whether these changes contribute significantly to gastrointestinal morbidity in old age.4
Refractory Anemia: A Disease or a Syndrome
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diseases of the Chest, Chicago
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Long-term correction of glycogen storage disease type II with a hybrid Ad-AAV vector
Authors: B Sun
Journal: Molecular Therapy (2003)

We administered an adenovirus-adeno-associated virus (Ad-AAV) vector encoding human acid α-glucosidase (hGAA) to acid α-glucosidase-knockout (GAA-KO) mice on day 3 of life by gastrocnemius injection. In contrast to previous results for muscle-targeted Ad vector in adult GAA-KO mice, the muscles of the hindlimb showed reduced glycogen content and persistent hGAA for as long as 6 months after neonatal Ad-AAV vector administration. Not only the injected gastrocnemius muscles, but also the hamstrings and quadriceps muscles produced therapeutic levels of hGAA as a result of widespread transduction with the Ad-AAV vector; moreover, hGAA activity was 50-fold elevated as compared to normal mice. Vector RNA was detected in the hindlimb muscles, the hearts, and the livers by northern blot analysis and/or by RT-PCR for as long as 6 months. The low levels of hGAA detected in the heart were attributable to transduction with the Ad-AAV vector, not to secretion of hGAA by the injected muscle and uptake by the heart. Finally, although an antibody response to hGAA was present, it did not prevent the correction of glycogen storage in the skeletal muscle of GAA-KO mice.
Membership Dues and Subscriptions.
Journal: JAMA (1884)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Arthritis: A Quarter Century of Research.
Journal: Annals of Internal Medicine (1978)

consecutive occasions by 5-day courses of intravenously not granted.administered cytosine arabinoside 100 mg/day.These data provide further evidence of the beneficial This patient was followed by us for a further period of effect of cytosine arabinoside in the symptomatic treat-22 months.During that time, while the haematological ment of patients with this condition.picture remained unchanged, he suffered from eleven episodes of excrutiating bone pain, always responsive to J. AsHEROV, Y. SHOENFELD, and J. PKHAS the same treatment.Repeated skeletal x-rays and bone Department of Medicine 'D', scans showed no osteolytic lesions.In December 1977 a
Specific mitochondrial DNA deletions in idiopathic dilated cardiomyopathy
Authors: J. Marin-Garcia, M. J. Goldenthal, R. Ananthakrishnan, M. E. M. Pierpont, F.J. Fricker, S. E. Lipshultz, A. Perez-Atayde
Journal: Cardiovascular Research (1996)

Objective: Structural changes in human mitochondrial DNA (mtDNA) have been implicated in a number of clinical conditions with dysfunctions in oxidative phosphorylation called OX-PHOS diseases, some of which have cardiac involvement. The objective of this study was to assess the frequency and extent of specific mitochondrial DNA deletions in idiopathic dilated cardiomyopathy. Methods: DNA extracted from tissue derived from the left ventricle of 41 patients with idiopathic dilated cardiomyopathy and 17 controls was amplified by polymerase chain reaction using specific primers to assess the incidence and proportion of 5-kb and 7.4-kb deletions in mitochondrial DNA. Results: In reactions using primers to detect the 5-kb deletion, an amplified product of 593 bp was found in low abundance relative to undeleted mitochondrial DNA but with high frequency in a number of controls and patients. A second deletion of 7.4 kb in size was also frequently present in controls and patients. In contrast to previous reports, these deletions were found to be present in both controls and in cardiomyopathic patients, 18 years and younger, including several infants. The 7.4-kb deletion was prominently increased in both frequency and in its proportion relative to undeleted mitochondrial DNA in patients 40 years and older with idiopathic dilated cardiomyopathy. Conclusions: At variance with current literature our study reports a significant presence of both 5 and 7.4-kb deletions in the young and a higher frequency and quantity of the 7.4-kb deletion in the older cardiomyopathic patients in comparison with controls. The increased accumulation of the 7.4-kb deletion as both a function of aging and cardiomyopathy is suggestive that this specific mitochondrial DNA deletion arises more likely as an effect of heart dysfunction rather than as a primary cause of cardiomyopathy.
Berlin Letter.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Response
Authors: Richard Wakeford
Journal: Environmental Health Perspectives (1996)

Sellafield or some other reported leukemia dusters, leaves little room for doubt by con- duding that "a causal interpretation of the association between childhood leukemia and paternal preconceptional irradiation reported by Gardner et al. cannot be sustained."Taken as a whole, while contributing to the ongoing discussion on intrauterine and preconceptional exposure risks for childhood cancers, Wakeford's paper in no way invalidates the major condusions from our review of the literature on health hazards from low- dose exposures.
Cost Analysis of the American Board of Internal Medicine's Maintenance-of-Certification Program
Authors: Christopher D. Adams
Journal: Annals of Internal Medicine (2016)

Letters19 April 2016Cost Analysis of the American Board of Internal Medicine's Maintenance-of-Certification ProgramChristopher D. Adams, MDChristopher D. Adams, MDFrom East Alabama Rheumatology Center, Opelika, Alabama.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L16-0006 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Sandhu and colleagues' cost analysis on the American Board of Internal Medicine's (ABIM) Maintenance-of-Certification (MOC) program (1) is the first step in what must become a serial evaluation of MOC value. We must determine whether the estimated time and expenses, which are substantial for an individual but gargantuan for the entire cadre of board-certified physicians, are really justified by the additional benefit or value provided to patients. According to my accountant, my personal direct and indirect costs to recertify for only the subspecialty of rheumatology in 2012 were much higher than the lowest estimate reported in the ...Reference1. Sandhu AT, Dudley RA, Kazi DS. A cost analysis of the American Board of Internal Medicine's Maintenance-of-Certification program. Ann Intern Med. 2015;163:401-8. [PMID: 26216046]. doi:10.7326/M15-1011 LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From East Alabama Rheumatology Center, Opelika, Alabama.Disclosures: Author has disclosed no conflicts of interest. Form can be viewed at www.acponline.org/authors/icmje/ConflictOfInterest Forms.do?msNum=L16-0006. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoA Cost Analysis of the American Board of Internal Medicine's Maintenance-of-Certification Program Alexander T. Sandhu , R. Adams Dudley , and Dhruv S. Kazi Cost Analysis of the American Board of Internal Medicine's Maintenance-of-Certification Program Alexander T. Sandhu , R. Adams Dudley , and Dhruv S. Kazi Cost Analysis of the American Board of Internal Medicine's Maintenance-of-Certification Program Lonnie Hanauer Metrics 19 April 2016Volume 164, Issue 8Page: 571KeywordsConflicts of interestDisclosureHealth careRheumatology ePublished: 19 April 2016 Issue Published: 19 April 2016 Copyright & PermissionsCopyright © 2016 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
The Southern Surgical and Gynecological Association Transactions.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SELECT-D: Anticoagulation therapy in selected cancer patients at risk of recurrence of venous thromboembolism.
Authors: Annie Young, Janet Dunn, Oliver Chapman, Joanne Grumett, Andrea Marshall, Jenny Phillips, Anand Lokare
Journal: Journal of Clinical Oncology (2014)

TPS9661 Background: Venous thromboembolism (VTE) in cancer patients is an important and increasingly frequent clinical problem. The impact of VTE on cancer patients can be considerable. Targeted selection by identifying patients with clinically relevant recurrent VTE may have wider health economic benefits whilst reducing patient risk through over-treatment. In the UK, dalteparin is the licensed anticoagulant for the extended treatment and prevention of recurrence of VTE in cancer patients and thus, the gold standard. Rivaroxaban is a highly selective direct Factor Xa inhibitor with oral bioavailability. Methods: Select-d is a prospective, randomised, open label, multicentre pilot trial comparing dalteparin (200 IU/kg daily subcutaneously for 1 month and 150 IU/kg months 2-6); and rivaroxaban (15 mg orally twice daily for 3 weeks and 20 mg once daily for 6 months in total) for cancer patients with VTE, with a second placebo-controlled randomisation (rivaroxaban vs placebo) comparing the duration of therapy (6 vs 12 months) in residual vein thrombosis (RVT) positive patients. 70% of patients are estimated to be RVT positive after initial treatment. 530 patients are being recruited toprovide reliable estimates of the primary outcome (VTE recurrence rates) to within the 95% confidence interval of 8% assuming VTE rates are 10% at six months. Secondary objectives include safety, acceptability, biomarker identification and health economics. The trial will recruit for two years with a minimum of one year follow up. Results will support optimal treatment for this key patient group. The independent TSC and DSMC fully support this important trial. At least 40 UK centres will participate in the trial. As of 1stFebruary 2014, 23 patients have been recruited from 24 open UK sites. Select-d is amongst the first randomised trials of the new oral anticoagulants in patients with cancer, following recent recommendations from the UK National Institute of Health and Care Excellence.(http://guidance.nice.org.uk/CG144, http://guidance.nice.org.uk/TA261, http://publications.nice.org.uk/quality-standard-for-diagnosis-and-management-of-venous-thromboembolic-diseases-qs29). Clinical trial information: 86712308.
THE SURGERY OF CAMP WIKOFF.
Authors: N. SENN
Journal: JAMA (1898)

The great national Camp Wikoff has been made the recipient of the returning army of Cuba. Three months ago the invasion of Cuba was ordered. Our troops left the different camps in excellent condition and good cheer to meet the Spanish army in the neighboring island, fully informed and impressed with the events that awaited them. The army of invasion considered it a privilege to be called to the front to represent the military prowess and power of this country. The outside world had no conception of what our army could accomplish at such short notice in a distant tropical country. The authorities, and particularly the medical department, were fully aware of the fact that the invasion of Cuba meant more a battle with climate and disease than the weakened, sickly, half starved Spanish forces. The invasion was planned on the spur of the moment, and the corps were rushed
Levarterenol irrigation. Control of massive gastrointestinal bleeding in poor-risk patients
Authors: H. O. Douglass
Journal: JAMA (1974)

Massive upper gastrointestinal hemorrhage occurred in 12 extremely poor-risk patients with advanced malignant disease. Previous experience in this institution indicated that most patients with similar conditions could be expected to die as a result of an equivalent bleeding episode. Intragastric or intraperitoneal administration of levarterenol bitartrate controlled the acute bleeding episode in 11 of the 12 patients. Rebleeding occurred in five, but was again controlled with levarterenol in three. Permanent control of bleeding was achieved in ten patients. Two of the four who left the hospital alive eventually had surgery. Only two of the 12 patients died as a result of hemorrhage. (<i>JAMA</i>230:1653-1657, 1974)