tbuckley/cabot-search huggingface dataset:
Getting good reception.
Journal: Environmental Health Perspectives (1999)

The human brain contains hundreds of billions of neurons and connections, all busily engaged in transmitting the specialized electrical messages that allow the mind and body to sense and respond to the myriad stimuli encountered each moment of every day. In the NIEHS Laboratory of Signal Transduction, scientists study the mechanisms by which environmental agents disrupt these neural pathways, thereby altering neurophysiological processes and, sometimes, causing or exacerbating environmentally related disease. Neuroscientist Jerrel L. Yakel, who heads the Ion Channel Physiology Group within the Laboratory of Signal Transduction, studies neurotransmitter receptors, proteins found on the surface of nerve cells that bind endogenous and exogenous chemical signaling agents.
Common Skin Diseases
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
802. Silencing of HIV-1 with RNA Interference: A Multiple shRNA Approach
Authors: Olivier ter Brake, Ben Berkhout
Journal: Molecular Therapy (2006)

Double-stranded RNA can induce gene silencing via a process known as RNA interference (RNAi). The double-stranded RNA can be expressed in the cell as a short hairpin RNA (shRNA) with a stem of 21–23 base pairs. Previously, we have shown that stable expression of a shRNA targeting the Nef gene of HIV-1 results in strong inhibition of HIV-1 replication. However, the application of this single shRNA was not sufficient to maintain inhibition. One of the hallmarks of RNAi, its sequence specificity, presented a way out for the virus, as single nucleotide substitutions in the target region abolished the inhibition. For the development of a durable gene therapy that prevents viral escape, we proposed to combine multiple shRNAs (ter Brake and Berkhout 2005). Therefore, we screened 86 different shRNAs targeting highly conserved regions. We identified multiple shRNAs that act as potent inhibitors of virus replication (Figure 1). We show, for the first time, that the expression of three different shRNAs from a single lentiviral vector results in similar levels of inhibition per shRNA as compared to single shRNA vectors. Thus, their combined expression results in an additive effect on inhibition of virus production. Moreover, when we expressed multiple shRNAs in a cell line that is susceptible for HIV-1 replication, viral escape was prevented. These results confirm that RNAi has great potential as antiviral gene therapy approach and supports our efforts to develop this strategy for the treatment of HIV-1 infected individuals. Brake, O. ter., and Berkhout, B. (Journal of RNAi and Gene Silencing 2005, 1(2): 56–65). Figure 1 86 shRNA expression plasmids were co-transfected with the HIV-1 molecularLAI and virus production measured. Figure 2Position of effective shRNA targets in the HIV-1 genome.
Dermatology
Authors: J. H. Epstein
Journal: JAMA (1978)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Chelating Agents in Biological Systems
Authors: Jack Schubert
Journal: Environmental Health Perspectives (1981)

Chelation enables metals to be transported to or from vulnerable target sites, and to hinder or facilitate their carcinogenic potential. In the reverse sense, metals are capable of ligand scavenging via complexation or mixed complex formation--the latter being the result of interaction with binary complexes. Consequently, metal complexes can be utilized for the transport of selected organic chemotherapeutic drugs to target organs, or for the decorporation of those toxic organic compounds which are able, before or after metabolic activation, of reacting with metals or 1:1 metal complexes. It is emphasized that the degree to which metal ions interact in vivo should employ the conditional constants which take into account competition from other ions, especially Ca2+, H+, and OH-. The genotoxic consequences of the various chemical factors involved in chelation, along with examples: kinetics, stabilization of oxoidation states, lipophilicity, and mixed ligand formation, are discussed.
Tissue Transplantation: New Approach to the "Typing" Problem
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Differential in vivo activity of docetaxel plus PS-341 combination therapy in non-small cell lung carcinoma (NSCLC) xenografts
Authors: P. H. Gumerlock, T. Kimura, W. S. Holland, C. D. D. Shih, P. N. Lara, D. R. Gandara
Journal: Journal of Clinical Oncology (2004)

7144 Background: Velcade (PS-341) is a selective proteasome inhibitor in early clinical trials in NSCLC patients. Docetaxel (Txt) is a microtubule-stabilizing taxane in wide clinical use for first- and second-line NSCLC therapy. We previously showed in NSCLC cell lines in vitro that the sequence of Txt prior to PS-341 showed the greatest levels of apoptosis by sub-G1 content and PARP cleavage, which was associated with accumulation of p27 and loss of Bcl2. Our hypothesis was that the combination of both agents will be more effective than either agent alone, and that the sequence of drugs will influence the response to treatment. Methods: We used the p53-null NSCLC Calu-1 xenograft model to evaluate responses to Txt or PS-341 and to combinations in the sequences of PS-341 before Txt, Txt before PS-341, and both simultaneously. Cells (5x106) were injected subcutaneously into each flank of male athymic nu/nu mice with 2 mice per group. The agents in the combination treatments were administered either together or 24hrs apart, with all regimens given weekly [IP doses: Txt: 10mg/kg; PS-341: 0.5mg/kg]. Tumor growth was measured up to six weeks after initial treatment. Results: PS-341 had a modest effect on tumor growth as a single agent (12% inhibition), while Txt had no effect. However, with each of the alternate sequences of drug administration (Txt→PS-341 and PS-341→Txt), tumor growth was inhibited approximately 40%. The simultaneous delivery of both drugs showed no inhibition of tumor growth compared to the control, demonstrating antagonism compared to PS-341 alone. Conclusions: Our studies demonstrate that different schedules of drug delivery affect the response to combinations of PS-341 with Txt. Furthermore, antagonism was suggested with simultaneous administration of both agents in vivo. Additional studies of alternate schedules are warranted, and these in vivo data set the stage for future clinical trials. Examination of apoptosis-associated proteins PARP, Caspase-3, p27, and Bcl2 is ongoing. (Aventis and Millennium provided docetaxel and PS-341, respectively.) Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Aventis Oncology
Carcinoembryonic Antigen
Authors: WILLIAM L. WOLFSON
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 May 1986Carcinoembryonic AntigenWILLIAM L. WOLFSON, M.D.WILLIAM L. WOLFSON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-104-5-724_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I am delighted that a series on diagnostic testing is underway, but a point in the first article (1), on carcinoembryonic antigen, needs clarification.Dr. Fletcher refers to a Dukes "D" lesion. There is no such animal. In the first Dukes classification (2), rectal carcinomas were classified as A, B, or C. This list was subsequently modified (3) to include C1 and C2 lesions, which differ in the location of positive node groups. Others have since added groups and changed Sir Cuthbert's original definitions, but it behooves us to use the Dukes classes correctly if we use...References1. FLETCHER R. Carcinoembryonic antigen. Ann Intern Med. 1986;104:66-73. LinkGoogle Scholar2. DUKES C. The classification of cancer of the rectum. J Pathol Bacteriol. 1932;35:323-32. CrossrefGoogle Scholar3. GABRIELDUKESBUSSEY WCH. Lymphatic spread in cancer of the rectum. Br J Surg. 1935;23:395-413. CrossrefGoogle Scholar4. KYRIAKOS M. The President's cancer, the Dukes classification, and confusion [Editorial]. Arch Pathol Lab Med. 1985;109:1063-6. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Hoag Memorial Hospital Presbyterian Newport Beach, CA 92663 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1986Volume 104, Issue 5Page: 724-724KeywordsCarcinoembryonic antigenLesions Issue Published: 1 May 1986 PDF downloadLoading ...
IFM2012-03
Authors: Xavier Leleu, Guillemette Fouquet, Lionel Karlin, Brigitte Kolb, Mourad Tiab, Carla Araujo, Nathalie Meuleman, Jv Malfuson, Pascal Bourquard, Pascal Lenain, Murielle Roussel, Arnaud Jaccard, Marie-Odile Petillon, Karim Belhadj-Merzoug, Gerard Lepeu, Marie-Lorraine Chretien, Jean Fontan, Philippe Rodon, Anna Schmitt, Fritz Offner, Laurent Voillat, Sophie Cereja, Frederique Kuhnowski, Sophie Rigaudeau, Olivier Decaux, Catherine Humbrecht-Kraut, Jamile Frayfer, Olivier Fitoussi, Damien Roos Weil, Jean Claude Eisenmann, Veronique Dorvaux, Eric G. Voog, Cyrille Hulin, Michel Attal, Philippe Moreau, Thierry Facon
Journal: Blood (2016)
Anticoagulant therapy and myocardial infarction
Authors: A. Selzer
Journal: JAMA (1980)

<h3>To the Editor.—</h3> The article by Szklo and associates (242:1261, 1979) and the accompanying editorial by Richard J. Jones, MD (242:1291, 1979), enter the controversial field of anticoagulant therapy in acute myocardial infarction and come strongly in favor of this therapy. Many followers of the 30-year-old controversy conclude that no valid study showing a favorable risk-benefit ratio of anticoagulant therapy has yet been designed. Presentation of a difference in mortality between treated and untreated patients is irrelevant to the subject, unless anticoagulant therapy or its lack is the only variable. The extremely broad range of clinical manifestations, complications, and risks of myocardial infarction makes it impossible to come up with well-matched groups without going into thousands of cases and preferably dealing with a prospective study. Many years ago McMichael,<sup>1</sup>commenting on the early studies dealing with anticoagulant therapy of myocardial infarction, came up with a curious observation: In all
Table of Contents
Authors: Christos Mantzoros, Faidon Magkos, Rajagopal Sekhar, Sanjeet Patel, Susana Amico, Jianjian Shi, Ashok Balasubramanyam, Khaleel Rehman, Farook Jahoor, Fehmida Visnegarwala, Masanori Moriguchi, Sinsuke Noso, Yumiko Kawabata, Takaaki Yamauchi, Takeshi Harada, Katsumori Komaki, Naru Babaya, Yoshihisa Hiromine, Hiroyuki Ito, Satomi Yamagata, Kaori Murata, Takahiro Higashimoto, Choongyong Park, Akinobu Yamamoto, Yasuhiro Ohno, Hiroshi Ikegami, Yong Zhang, Longchang Jiang, Wenjun Hu, Qichang Zheng, Wenpei Xiang, Takhar Kasumov, John Edmison, Srinivasan Dasarathy, Carole Bennett, Rocio Lopez, Satish Kalhan, Arjeta Gusinjac, Annemarie Gagnon, Alexander Sorisky, Tsuyoshi Uchiyama, Shoichi Tomono, Toshihiro Utsugi, Yoshio Ohyama, Tetsuya Nakamura, Hideaki Tomura, Shoji Kawazu, Fumikazu Okajima, Masahiko Kurabayashi, Chi-Yuan Chao, Jin-Shang Wu, Yi-Ching Yang, Chi-Chen Shih, Ru-Hsueh Wang, Feng-Hwa Lu, Chih-Jen Chang, Tokio Matsunami, Yukita Sato, Satomi Ariga, Takuya Sato, Toshiko Shimomura, Haruka Kashimura, Yuki Hasegawa, Masayoshi Yukawa, Makoto Daimon, Toshihide Oizumi, Shigeru Karasawa, Wataru Kaino, Kaoru Takase, Kyouko Tada, Yumi Jimbu, Kiriko Wada, Wataru Kameda, Shinji Susa, Masaaki Muramatsu, Isao Kubota, Sumio Kawata, Takeo Kato
Journal: Metabolism (2011)
Letters, Notes, and Answers to Correspondents
Authors: M Eng, Suffolk Hospital, Ipswich Jefferson, B Arthur, M Lond, Dispensary Jolly, S Aird, Goldsmiths Almshouses, Mr Francis, Rees Thomas, L Glasg, Llandovery Jones, W Black, Llangammarch Wells, Wales Kerr, H Colley March, Reappointed Medical, C Lamplough, Basford Union, M James, Glossop-Dale Rural, District Robinson, J Russell, W Colman, Assistant Sellers, L Lond, J Stewart, Lostwithiel Townsend, St Infirmary, George Edward, Aylesbury Female, Convict Prison, Richard Brayn, M Wood, L Edin, Seymour Taylor, Dodson.-On March, Arthur Dodson, Hughes.-On March, Gwernllwyn House, H Hughes, -On March, Cambrian Villa, James Menzies, S Street, G Pitt, Abraiams-Simmons.-On March, Revs Samuel, R Harris, Bertram Louis, Welbeck Street, L Abrahams, A Simmons, Preston.-On March, St Jude's Church, Rev May, Charles Goodhart May, Royal Navy, Rev May, Emily Daisy, Kong Hong
Journal: BMJ (1896)
Fifty Hours for the Poor
Authors: George D. Lundberg
Journal: JAMA (1988)

Doctors, lawyers, and the clergy belong to the classic learned professions, which are historically distinguished from trades and businesses. Although this distinction has blurred in modern times, one of the characteristics of a true profession remains its special relationship with the poor. Edmund Pellegrino, director of the Kennedy Institute of Ethics, states that a fundamental difference between a business and a profession is that "at some point in the professional relationship, when a difficult decision is to be made, you can depend on the one who is in a true profession to efface his own self-interest." The privilege to practice law or medicine has carried with it the obligation to serve the poor without pay. Doctors and lawyers today have tended to become overly concerned with their professional incomes and practice efficiencies, but they must not forget their higher duties. Many members of our professions have always cared for the
Gross and microscopic lesions in the female SENCAR mouse skin and lung in tumor initiation and promotion studies.
Authors: G L Knutsen, R M Kovatch, M Robinson
Journal: Environmental Health Perspectives (1986)

The skin and lung tissues from SENCAR mice used as part of the Environmental Protection Agency's (EPA's) Carcinogenesis Testing Matrix were examined. This study included SENCAR mice used in three different short-term bioassay protocols in which the skin papilloma assay was used to identify initiators, promoters, and complete carcinogens. Also included were the pathology findings from SENCAR mice used in the combined bioassay in which the skin assay and the lung adenoma assay were conducted simultaneously. The gross and microscopic features of treatment-associated and spontaneous lesions of the skin and lung of the SENCAR mouse used in these studies are defined and the lesions most commonly observed are described. Generally, gross observations and microscopic findings in both the skin and lung tissues were poorly correlated. Although there are several definite criteria on which gross interpretations of the various skin and lung lesions can be made, with the exception of pedunculated squamous cell papillomas and the classic squamous cell carcinomas, the various lesion types had a wide variety of clinical presentations that severely compromised the accuracy of gross diagnosis. Further, in the case of benign skin neoplasms, malignant transformation of these tumors most often occurred at the base of the lesion and was initially hidden from gross observation. As a result, approximately 50% of the neoplasms interpreted clinically as benign tumors (papillomas and keratoacanthomas) were actually malignant neoplasms. Moreover, many lesions determined grossly to be nontumorous were in fact found to be neoplastic when examined microscopically. The SENCAR mouse was found to be more responsive in the lung adenoma assay than other strains examined with exception of the Strain A. Although accurate interpretation of the lung lesions in the SENCAR was compromised by nonneoplastic treatment-associated and/or spontaneous lesions, the feasibility of using the SENCAR skin and lung as target tissues in two-stage combined carcinogenesis studies merits further consideration.
Untoward effect of a face peel: toxic shock syndrome
Authors: M. Korcok
Journal: JAMA (1982)

Toxic shock syndrome (TSS) continues to occur in strange situations. One of the most recent concerns a transsexual Canadian man who contacted the disease while undergoing a full chemical face peel to fight off the ravages of wrinkling, electrolysis scarring, and mild acne. The case was reported to the annual meeting of the American Academy of Facial Plastic and Reconstructive Surgery in Palm Beach, Fla, by John R. Dmytryshyn, MD, clinical instructor in the Department of Otolaryngology at the University of British Columbia Health Sciences Centre, Vancouver. Dmytryshyn said that the 42-year-old man underwent a full-thickness chemical peel under general anesthesia. The peel ingredients included 3 mL of 89% phenol, 2 mL of tap water, 7 drops of Septisol, and 3 drops of croton oil. Postoperative swelling was controlled for the first four days by continuous application of cool compresses and dexamethasone, 12 mg per day. On the fifth day,
2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults
Authors: Neil J. Stone, Jennifer G. Robinson, Alice H. Lichtenstein, C. Noel Bairey Merz, Conrad B. Blum, Robert H. Eckel, Anne C. Goldberg, David Gordon, Daniel Levy, Donald M. Lloyd-Jones, Patrick McBride, J. Sanford Schwartz, Susan T. Shero, Sidney C. Smith, Karol Watson, Peter W.F. Wilson
Journal: Journal of the American College of Cardiology (2013)
Nederlands Tijdschr Geneeskunde, Amsterdam
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal