tbuckley/cabot-search huggingface dataset:
Adipose-derived resistin and gut-derived resistin-like molecule–β selectively impair insulin action on glucose production
Authors: Michael W. Rajala, Silvana Obici, Philipp E. Scherer, Luciano Rossetti
Journal: Journal of Clinical Investigation (2003)

The adipose-derived hormone resistin is postulated to link obesity to insulin resistance and diabetes. Here, the infusion of either resistin or the resistin-like molecule–β (RELMβ) rapidly induced severe hepatic but not peripheral insulin resistance. In the presence of physiologic hyperinsulinemia, the infusion of purified recombinant resistin, increasing circulating resistin levels by approximately twofold to 15-fold, inhibited glucose metabolism such that lower rates of glucose infusion were required to maintain the plasma glucose concentration at basal levels. The effects of resistin and RELMβ on in vivo insulin action were completely accounted for by a marked increase in the rate of glucose production. These results support the notion that a novel family of fat- and gut-derived circulating proteins modulates hepatic insulin action.
Avoidance of surgical hyperglycemia in diabetic patients
Authors: R. E. Woodruff
Journal: JAMA (1980)

Strict intraoperative glucose level control was accomplished with constant low-dose glucose infusion of 100 mg/kg/hr and variable infusion rates of insulin to control serum glucose levels as follows: 20 units/hr for serum glucose levels greater than 200 mg/dL, 1 unit/hr for levels between 80 and 200 mg/dL, and no insulin for levels less than 80 mg/dL. Using this technique, eight diabetic patients with serum glucose levels greater than 250 mg/dL before surgery had their serum glucose levels brought rapidly under control (ie, glucose level less than 200 mg/dL), which continued postoperatively. (<i>JAMA</i>244:166-168, 1980)
Hepatic ICG removal in the pig depends on plasma protein and hematocrit: Evidence of sinusoidal binding disequilibrium and unstirred water layer effects
Authors: P Ott, L Bass, S Keiding
Journal: Hepatology (1997)

The influence of binding protein concentration and hematocrit on hepatic uptake of indocyanine green (ICG) was studied in anesthetized pigs during constant infusion of ICG. By exchange transfusions, we either substituted plasma protein with dextran 70 (n = 8) or changed hematocrit (n = 8). Intrinsic hepatic clearance of ICG, K, was calculated from plasma flow rate and concentrations in peripheral artery and liver vein after correction for extrahepatic distribution. By analyzing the relative change of K versus either the protein dilution factor or the change in plasma volume fraction (1-hct), we evaluated four current models for hepatic uptake of protein-bound substances even though a number of model parameters were unknown (parameter-free testing). Protein dilution factors (unitless) of 0.506 ± 0.027, 0.673 ± 0.011, and 0.749 ± 0.028 were associated with inverse K ratios of 0.621 ± 0.025, 0.758 ± 0.021, and 0.817 ± 0.013. These data rejected the traditional hypothesis that ICG uptake is proportional to the unbound concentration. They were compatible with development of binding disequilibrium along the sinusoidal lumen, an unstirred water layer close to the hepatocyte surface, or facilitated uptake from the bound pool. A plasma volume ratio [(1-hct 2 )/(1-hct 1 )] of 1.14 ± 0.02 was associated with a K ratio of 1.07 ± 0.02 ( P = .01). Only sinusoidal binding disequilibrium predicted this finding, whereas an additional unstirred water layer effect could not be excluded. The observations could be simulated by a model that included both of these effects. Thus, neither the relative changes of K nor the absolute K values required the assumption of facilitated uptake from the bound pool. The parameter-free design presented may be useful with other ligands in intact animals.
THE EXTERNAL TREATMENT OF PSORIASIS A CONTROLLED INVESTIGATION OF THE EFFECTS OF DITHRANOL
Authors: E. YOUNG
Journal: British Journal of Dermatology (1970)

Journal Article THE EXTERNAL TREATMENT OF PSORIASIS A CONTROLLED INVESTIGATION OF THE EFFECTS OF DITHRANOL Get access E. YOUNG E. YOUNG Dermatological Department, The State University, Utrecht, Netherlands Director: Prof. Dr L. H. Jansen Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 82, Issue 5, 1 May 1970, Pages 516–520, https://doi.org/10.1111/j.1365-2133.1970.tb02215.x Published: 01 May 1970 Article history Accepted: 10 November 1969 Published: 01 May 1970
Mental Testing of Children Under Three Years
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Popular, yes, but jury still out on apnea surgery
Authors: C. A. Raymond
Journal: JAMA (1986)

SINCE 1981, when Japanese surgeon Shiro Fujita, MD, and colleagues described their version of the procedure, uvulopalatopharyngoplasty (UPPP) has become an increasingly popular—but far from universally accepted—option for treating patients who suffer from snoring and/or severe obstructive sleep apnea (<i>JAMA</i>[MEDICAL NEWS] 1985;254:1275-1284). The National Center for Health Statistics in Hyattsville, Md, estimates that 5000 people underwent this type of surgery during 1983 and 1984. The charge for the surgery itself varies from $1000 to $2000 across the country, according to one surgeon familiar with the procedure; this does not include the cost of hospitalization for up to three days or other charges. Surgeons using this procedure report widely different success rates, ranging from 23% to 75%. At the Triological Society Spring Meeting in Palm Beach, Fla, surgeons from across the country tried to assess the meaning of such disparate results. One conclusion, noted by Roger L. Crumley, MD, a
苏金单抗治疗对清除指甲银屑病非常有效: TRANSFIGURE 临床试验的长期结果
Journal: British Journal of Dermatology (2021)

TRANSFIGURE 是一项纳入 198 例患者的 III 期临床试验。III 期试验旨在提供是否可批准某疗法用于一般公众的最终证 据。它在全球多个国家/地区进行
Abstract 3607: Inhibition of mutant IDH enzymes reduces production of 2-HG but does not restore wild type IDH activity <i>in vitro</i> or <i>in vivo</i>
Authors: Katie Sellers, Taryn Sleger, Sebastien Ronseaux, Rohini Narayanaswamy, Christine Hudson, Thomas Roddy, Brandon Nicolay
Journal: Cancer Research (2019)

Abstract Mutations in isocitrate dehydrogenase (IDH) 1 and 2 occur in variety of malignancies, and notably &amp;gt;70% of low grade gliomas. These mutations lead to neomorphic enzymatic activity that results in the production of the oncometabolite (D)-2-hydroxyglutarate (2-HG) through the consumption of NADPH. IDH mutant cells and tumors have been shown to have heightened sensitivity to reactive oxygen species (ROS) and radiation, though it is unclear if this sensitivity is due to a loss of IDH wild type enzymatic NADPH production, the neoenzymatic activity of the mutant enzyme, or a combination of these activities. In support of the hypothesis that sensitivity to ROS and radiation is due to a reduced IDH wild type activity in IDH mutant cells, we previously demonstrated that combined treatment of mutant IDH mouse xenografts with AG-881, a potent orally available mutant IDH inhibitor, and radiation resulted in superior tumor growth inhibition than either modality alone. To extend this investigation, we have now developed a novel assay to read out the wild type activity of IDH1/2 enzymes in both cell-based assays and mouse xenograft models. Using an isotopic labeling approach that allows us to fully differentiate the activity of wild type IDH1/2 from the mutant enzymatic activity in the same cell or tumor, we observed that mutant IDH cells and tumors have a significantly reduced level of wild type IDH1/2 activity compared to normal tissue or IDH wild type tumors. Importantly, pharmacologic inhibition of mutant IDH1/2 that resulted in &amp;gt;90% reduction in 2-HG production in mutant cells and tumors did not restore the IDH1/2 wild type activity. These data support our previous observations and suggest that therapeutic strategies targeting the reduced activity of wild type IDH enzymes, such as modalities that induce ROS or treatment with radiation, would be effective when combined with mutant IDH inhibitors. Citation Format: Katie Sellers, Taryn Sleger, Sebastien Ronseaux, Rohini Narayanaswamy, Christine Hudson, Thomas Roddy, Brandon Nicolay. Inhibition of mutant IDH enzymes reduces production of 2-HG but does not restore wild type IDH activity in vitro or in vivo [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3607.
HEROISM AND SCIENTIFIC PROGRESS
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Seventy-Eighth Annual Meeting of the American Association for Cancer Research
Journal: JNCI Journal of the National Cancer Institute (1986)

Seventy-Eighth Annual Meeting of the American Association for Cancer Research Get access JNCI: Journal of the National Cancer Institute, Volume 77, Issue 6, December 1986, Page 1315, https://doi.org/10.1093/jnci/77.6.1315-e Published: 01 December 1986
An uncommon cold clinic is faring quite well
Journal: JAMA (1981)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Male infertility, impaired spermatogenesis, and azoospermia in mice deficient for the pseudophosphatase Sbf1
Authors: Ron Firestein, Peter L. Nagy, Megan Daly, Phil Huie, Marco Conti, Michael L. Cleary
Journal: Journal of Clinical Investigation (2002)

Pseudophosphatases display extensive sequence similarities to phosphatases but harbor amino acid alterations in their active-site consensus motifs that render them catalytically inactive. A potential role in substrate trapping or docking has been proposed, but the specific requirements for pseudophosphatases during development and differentiation are unknown. We demonstrate here that Sbf1, a pseudophosphatase of the myotubularin family, is expressed at high levels in seminiferous tubules of the testis, specifically in Sertoli's cells, spermatogonia, and pachytene spermatocytes, but not in postmeiotic round spermatids. Mice that are nullizygous for Sbf1 exhibit male infertility characterized by azoospermia. The onset of the spermatogenic defect occurs in the first wave of spermatogenesis at 17 days after birth during the synchronized progression of pachytene spermatocytes to haploid spermatids. Vacuolation of the Sertoli's cells is the earliest observed phenotype and is followed by reduced formation of spermatids and eventual depletion of the germ cell compartment in older mice. The nullizygous phenotype in conjunction with high-level expression of Sbf1 in premeiotic germ cells and Sertoli's cells is consistent with a crucial role for Sbf1 in transition from diploid to haploid spermatocytes. These studies demonstrate an essential role for a pseudophosphatase and implicate signaling pathways regulated by myotubularin family proteins in spermatogenesis and germ cell differentiation.
Auscultation
Authors: Jerald Winakur
Journal: Annals of Internal Medicine (2005)

Ad Libitum7 June 2005AuscultationJerald Winakur, MDJerald Winakur, MDFrom The Center for Medical Humanities and Ethics, University of Texas Health Science Center, San Antonio, TX 78284.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-142-11-200506070-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Beyond the stacksof textbooks studiedamong the piles of journalsread and notpulsing in thoseglove-numbed handsinside the stiff white coatstarched to armornoosed in the caduceusdrumming deep withinthe black coilsbetween the endless roundsthe endless dyingsstill beatsa poet's heartand it pounds againand pounds againnow that you havefinally clutchedthis instrumentto your own chest. Author, Article, and Disclosure InformationAffiliations: From The Center for Medical Humanities and Ethics, University of Texas Health Science Center, San Antonio, TX 78284.Current Author Address: Jerald Winakur, MD, PO Box 128, Comfort, TX 78013. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 7 June 2005Volume 142, Issue 11Page: 951KeywordsAuscultationHeartThorax ePublished: 7 June 2005 Issue Published: 7 June 2005 Copyright & PermissionsCopyright © 2005 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Annals of Internal Medicine, Philadelphia
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
1998 Neurotumor Club March 30, 1998, New Orleans, La.
Authors: Candece L. Gladson, Abhijit Guha, Albert J. Wong
Journal: Neuro-Oncology (1999)

Tumor cell invasion requires tumor cell attachment to the extracellular matrix, secretion of proteases that digest the extracellular matrix, and tumor cell motility.These events are amplified or modified by a complex series of signaling events.Some of these signaling events are initiated by growth factor or extracellular matrix protein interaction with tumor cell surface receptors (e.g., growth factor receptors and integrin receptors), whereas others are initiated inside the cell by the altered mechanism of action of tumor suppressor genes and signaling molecules.In the summary of 10 presentations below, there are examples of the expression of up-regulated or mutated molecules that trigger signaling events in malignant gliomas, Schwannomas, and meningiomas.These signaling events typically result in tumor cell proliferation or motility.Expression of several normal and constitutively activated mutant growth factor receptors are growth promoting in malignant astrocytomas.The work of Matt Feldkamp and A.
STATE MEDICINE.
Authors: Thad. M. Stevens
Journal: JAMA (1885)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tracking senile cataracts
Journal: JAMA (1980)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CAROTINEMIA IN AN ADULT
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bleeding gastritis induced by long-term release aspirin
Authors: J. R. Hoon
Journal: JAMA (1974)

ASPIRIN is a great drug, but.... Upper gastrointestinal bleeding with ingestion of aspirin is quite well known.<sup>1-3</sup>It is supposedly seen principally in susceptible individuals,<sup>4</sup>but Richard McCray<sup>5</sup>has averred that the aspirin bleedings can occur at times in anyone. Symptoms include epigastralgia, hematemesis, or merely melena, severe anemia, or chronic malaise. By gastrocamera, multiple bleeding points have been found in the stomachs of many subjects after ingestion of aspirin. Recently, with the gastrocamera, hemorrhagic gastritis has been 3demonstrated in several persons who had never experienced epigastralgia or bleeding with ordinary aspirin. These bleedings occurred after ingestion of a slow-release form of aspirin (Bayer Timed-Release Aspirin). This took place while I was attempting to define with the gastrocamera the period of retention of photographically evident slow-release aspirin in the stomach. <h3>Testing With Aspirin</h3> One of my subjects, a 19-year-old girl, had been examined at a one-half hour
Highlights
Journal: JAMA (2017)

Iron Repletion and Exercise Capacity in Patients With Heart Failure 1958 In patients with heart failure, iron defi ciency is associated with reduced functional capacity, poor quality of life, and increased mortality.The results of intravenous iron repletion trials have been favorable, but treating patients with intravenous iron products is expensive and poses logistical challenges for outpatients.To learn whether oral iron would be benefi cial for these patients, Lewis and colleagues randomized 225 patients with iron defi ciency and heart failure with reduced left ventricular ejection fraction and found that high-dose oral iron did not improve exercise capacity over 16 weeks.