tbuckley/cabot-search huggingface dataset:
THE ORIGIN OF PARASITISM.
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Association News
Journal: JAMA (1930)

<h3>THE PHILADELPHIA SESSION</h3><h3>Dates for Annual Session</h3> The Eighty-Second Annual Session of the American Medical Association will be held in Philadelphia, June 8 to 12, 1931. It was first thought that the session could be held in May but, because of conditions affecting the buildings to be used for exhibits and section meeting places, it was necessary to select June 8 to 12. <h3>MEDICAL BROADCAST FOR THE WEEK</h3><h3>American Medical Association Health Talks</h3> The American Medical Association broadcasts at 10 a. m. on Monday, 10: 15 on Tuesday, and 10 a. m. on Saturday, over Station WBBM (770 kilocycles, or 389.4 meters). The program for the week is as follows: November 3. Protecting the Surface. November 4. Health on Display. November 8. Constipation and Colitis. Five Minute Health Talks may be heard over the Columbia Broadcasting System daily except Sundays and holidays, from 12 to 12:05 p. m. The program
Abstract P5-08-01: Investigating the role of BRCA1 in sensitivity to GRN163L, a telomerase template antagonist
Authors: EA Phipps, SM Gryaznov, B-S Herbert
Journal: Cancer Research (2012)

Abstract Background: BRCA1 is a tumor suppressor gene with a variety of functions related to safeguarding genomic integrity. The regulation of telomere length is also crucial in maintaining genomic stability, with critically short telomeres leading to telomere uncapping, end-to-end fusions, activation of the DNA damage response, and cell cycle arrest. The objective of this study was to determine whether GRN163L, a telomerase template antagonist currently in clinical trials, has enhanced activity in BRCA1 mutant breast or ovarian cancer cell lines compared to BRCA1 wild-type breast/ovarian cancer cell lines. Methods: We utilized a panel of breast and ovarian cancer cell lines harboring both N-terminal and C-terminal BRCA1 mutations. This cell line panel included two isogenic cell line pairs reconstituted with wild-type BRCA1 (BRCA1 mutant: HCC1937 and UWB1.289; BRCA1 wild-type reconstituted: HCC1937+BRCA1 and UWB1.289+BRCA1). We assessed the effects of GRN163L or a mismatch oligonucleotide (MM) on telomerase activity and telomere length using the TRAP (Telomere Repeat Amplification Protocol) and TeloTAGGG (Roche) assays, respectively. Clonogenic survival assays, proliferation assays, and immunofluorescence were used to assess cellular responses to GRN163L and their molecular mechanisms. Results: All cell lines tested exhibited a dose-dependent response to treatment with GRN163L, but not a mismatch control oligonucleotide. The majority of the cell lines tested showed gross morphological changes as early as 12 hours following inhibitor treatment. Progressive telomere shortening was evident after 3-week treatment with GRN163L, but not after treatment with MM. We observed differential sensitivity between BRCA1 mutant and wild-type isogenic cell line pairs to GRN163L in clonogenic survival assays. GRN163L pretreatment was synergistic with cisplatin in UWB1.289 and UWB1.289+BRCA1 cells. Simultaneous treatment with GRN163L and doxorubicin was synergistic in HCC1937 and HCC1937+BRCA1 cells. Long-term (12-week) treatment with GRN163L preferentially induced complete cell death in HCC1937 (BRCA1 mutant) breast cancer cells compared to HCC1937 cells reconstituted with wild-type BRCA1. One-week treatment with GRN163L was sufficient to induce γ-H2AX foci, with more γ-H2AX positive cells in the UWB1.289 BRCA1 mutant cell line. Conclusions: Telomerase inhibition may be a viable treatment in BRCA1 mutant breast or ovarian cancers. These data provide insights into further investigations on the role of BRCA1 in the DNA damage response to GRN163L or combination treatment. Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P5-08-01.
TUBERCULOSIS OF THE FEMALE GENERATIVE ORGANS.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
<i>Erratum</i>: Vol. 64, No. SS-10
Journal: MMWR Morbidity and Mortality Weekly Report (2020)

In the Surveillance Summary "Abortion Surveillance -United States, 2011," data on the number of known previous induced abortions for women having abortions in this reporting year were erroneously included for New York City.These data did not meet reporting standards and should have been excluded from this report.When corrected, among women with abortions in the reporting year, the proportion with no previous induced abortions increased, and the proportion with one or more previous induced abortions decreased.On page 8, the first paragraph should have read "Data from the 37 areas that reported the number of previous abortions for women who obtained abortions in 2011 indicate that the majority (56.9%) had no previous abortions, 36.1% had one to two previous abortions, and 7.1% had three or more previous abortions (Table 19).Among the 30 reporting areas ¶ ¶ ¶ ¶ that provided data for the relevant years of comparison (2002 versus 2006, 2007 versus 2011, and 2010 versus 2011), the percentage of women who had one to two previous abortions was stable, although there was a decrease among women who had zero previous abortions and an increase among women who had three or more previous abortions.Among the areas included in this comparison, 57.8%, 36.0%, and 6.2% of women had zero, one to two, or three or more previous abortions, respectively, in 2002; by contrast, 57.0%, 35.9%, and 7.2% of women had zero, one to two, or three or more previous abortions, respectively, in 2011."New York City should have been included in the ¶ ¶ ¶ ¶ footnote, which lists reporting areas that were not included in these estimates.In Table 19, the line for New York City should be deleted.For the total line, the numbers and percentages should have read 229,909 (56.9), 102,612 (25.4), 43,159 (10.7), 28,593 (7.1), 404,273 (97.8).
Corrections to “P–0271 Concurrent oral UFT and pelvic irradiation as neoadjuvant chemoradiation for operable rectal cancer: a phase II study”
Authors: S. Helmy, A.A. Abo-Zeid, N.M. Gado, M.I. Salman, M.M. Bassyoni, A. Abd Al Samee, D.A. Salem
Journal: Annals of Oncology (2014)
Duplicate Publication
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 4944: Differential expression of complex immune biology in MSI and MSS colorectal tumor microenvironments using high-plex spatial resolution
Authors: Kit Fuhrman, Sarah Church, Daniel Zolligner, Jason Reeves, Doug Hinerfeld, Christina Bailey, Sarah Warren
Journal: Cancer Research (2019)

Abstract Spatial characterization of the tumor microenvironment (TME) including cancer cells, stroma and immune cells is essential for understanding tumor progression and discovering prognostic and predictive biomarkers. However, it has proven difficult to perform such studies in a highly multiplexed manner using limited sample quantity. GeoMx™ Digital Spatial Profiling (DSP) has been developed as an integrated research use platform for hi-plex spatial profiling of mRNA and protein using an optical-barcode read-out without the need for on-tissue molecular biology. In this study, we combined both bulk gene expression analysis using the NanoString PanCancer IO360™ panel and the spatial analysis of 40 proteins and 78 RNAs to characterize microsatellite stable (MSS) or instable (MSI) colorectal tumors to evaluate active and suppressive immune mechanisms in both immune dense regions and tumor versus stroma. Comparing colorectal tumors characterized by MSS, spatial analysis of RNA and protein expression by DSP was able to differentiate immune hot and cold regions of the tumors despite MSS status. Furthermore, comparison of immune-enriched hot-spots, measured by CD45 dense regions of interest, showed that MSS immune hot tumors had decreased macrophage and tumor proliferation markers compared to MSI immune hot tumors, elucidating potential therapeutic targets. Since there is a subset of patients with MSS colorectal cancer that still responds to immunotherapy, this suggests DSP could ultimately be used to identify unique spatial biology and immune characteristics that might further expand beyond MSS and MSI status and tradition gene signatures to help predict patients' response to mono- or combination therapy. Citation Format: Kit Fuhrman, Sarah Church, Daniel Zolligner, Jason Reeves, Doug Hinerfeld, Christina Bailey, Sarah Warren. Differential expression of complex immune biology in MSI and MSS colorectal tumor microenvironments using high-plex spatial resolution [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4944.
IgA, IgG, and IgM-antibodies against acetaldehyde adducts in vivo in problem drinkers with and without liver disease EP Central Hospital Laboratory, Sein�joki, Finland and *Addition Research Foundation, Toronto, Canada
Journal: Hepatology (1995)

This study was implemented to evaluate whether perivenous cells experience functional alterations due to a deficit in oxygen tension resulting from ethanol oxidation in the periportal regions of the lobule. Periportal and perivenous hepatocytes were prepared from ethanol-fed and control animals (Lieber-DeCarli diet, 31 days). These cells were either incubated at various oxygen tensions by varying the composition of the gases utilized to equilibrate the incubation buffers (0, 5, 25, and 95% oxygen) or they were unincubated. They were analyzed for adenine nucleotide and inorganic phosphate concentrations and from these data phosphorylation potentials and energy charge values were determined. Under highly aerobic conditions no differences were observed in the energy states of the cells irrespective of their source (control vs ethanol-fed; periportal vs perivenous). The ATP concentrations, phosphorylation potentials, and energy charge values indicated that the energy states of cells from both ethanol-fed and control rats were maintained at relatively high levels in incubations with 5 and 25% oxygen. However, unincubated cells and those incubated at 0% oxygen demonstrated lowered energy states and the decreases were most striking in hepatocytes from ethanol-fed animals. Measurements of LDH loss and trypan blue exclusion indicate that cell leakage and viability loss occur when cells are incubated under anoxic and hypoxic conditions. At low oxygen tensions perivenous cells from ethanol-fed rats demonstrated much greater loss of structural stability than did the other cell preparations. These observations indicate that decreased energy state is one factor which contributes to cell damage in hepatocytes from ethanol-fed animals. Moreover, perivenous cells from ethanol-fed animals seem to be particularly vulnerable to damage under hypoxic conditions.
Notification of Tuberculosis: A Correction
Authors: Brighton Mess, Co Burgoyne, London Bnrton, G Baird, L Bryson, N Brewis, Bloemfontein Bidwell, Mr Beards, G Barron, M Bidwell, Londton Bright, Miss Bulien, Wye Cousins, Windlesham Creasy, Mr Custance, E Coleman, F Collie, ; London, London Collingwood, E Cooper, Lincoln Cant, Mr Oripps, ; Carwardine, Clifton Mr, T Clouston, L Davies, L Dillon, L Damon, A Daldy, T Dutton, ; Devereux, S Davies, Mr Ellis, Buda-Pesth Eckstein, Mr Eddowes, W Mca, W Farquharson, J Ferguson, R Fox, G Ballygar, M Farmer, G Fordham, Florence Grocoo, G Grant, C Gooding, L Guthrie, Mr London, ) Hases, V Harley, J Henry, Sunbury Haslett, J Highet
Journal: BMJ (1899)

Reference should also be made to articles in Clifford Allbutt's Systean of Medicine (London: Mac- millan and Co
Reprint Address
Journal: JAMA (1978)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Roller Bandage, with a Chapter on Surgical Dressing.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
American Bittern, Sweetwater Preserve, Gainesville, Florida
Journal: JAMA Internal Medicine (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
ata glance..: one-minute abstracts of the current literature on cancer...
Journal: CA A Cancer Journal for Clinicians (1953)

biopsy specimen, mainly because the lesion is so often not grossly apparent.Between 0.5 to 1.0 per cent of smears from â€oe¿ noncancerousâ€•-appearing cer vixes reveal unsuspected cervical car cinomas that are usually preinvasive.Cervical smears have become a valu able adjunct in the detection of early carcinoma.
Metformin Improves Endothelial Vascular Reactivity in First-Degree Relatives of Type 2 Diabetic Patients With Metabolic Syndrome and Normal Glucose Tolerance
Authors: Luiz Guilherme Kraemer de Aguiar, Luciana R. Bahia, Nivaldo Villela, Camila Laflor, Fernando Sicuro, Nicolas Wiernsperger, Daniel Bottino, Eliete Bouskela
Journal: Diabetes Care (2006)

OBJECTIVE—Endothelial dysfunction is an early marker of atherosclerosis seen in type 2 diabetic subjects. Metformin is commonly used in the treatment of type 2 diabetes and has known vasculoprotective effects beyond its hypoglycemic ones. We aimed to investigate the vascular effects of metformin in first-degree relatives with metabolic syndrome of type 2 diabetic patients. RESEARCH DESIGN AND METHODS—The study included 31 subjects (age 38.3 ± 7.6 years and BMI 36.3 ± 5.2 kg/m2), who were first-degree relatives of type 2 diabetic patients and who had metabolic syndrome and normal glucose tolerance. The subjects were randomly assigned 1:1 in a double-blind fashion to receive placebo (n = 15) or metformin (n = 16). Endothelial function was assessed by venous occlusion plethysmography, measuring forearm blood flow (FBF) and vascular resistance responses to three intra-arterial infusions of endothelium-dependent (acetylcholine 7.5, 15, and 30 μg/min) and independent (sodium nitroprusside 2, 4, and 8 μg/min) vasodilators. Weight, BMI, systolic and diastolic blood pressure, waist, and laboratory parameters (lipid profile and fasting plasma glucose [FPG]) were assessed at baseline and after treatment. RESULTS—The metformin and placebo groups did not differ in anthropometric, clinical, laboratory, and vascular measurements at baseline. The metformin group had decreased weight, BMI, systolic blood pressure, and FPG and improved lipid profile. Endothelium-dependent FBF responses were also improved, without any effect on endothelium-independent responses. There was no correlation between the improvement on FBF responses and the observed changes on anthropometric, clinical, and laboratory parameters. CONCLUSIONS—We concluded that metformin improved vascular endothelial reactivity in first-degree relatives with metabolic syndrome of type 2 diabetic patients, independently of its known antihyperglycemic effects.
Technique of compression in closed-chest cardiac massage
Authors: H. L. Falsetti
Journal: JAMA (1967)

THE SUCCESSFUL reversal of cardiac arrest by cardiopulmonary resuscitation has been well documented. The controversal question of whether external or internal cardiac massage is more effective has still not been solved. Recent evidence favors the use of open-chest cardiac massage if appropriaate facilities are available and the patient has not responded to 10 to 15 minutes of closed-chest massage.<sup>1</sup>Higher cardiac output with open-chest resuscitation has been shown in animals<sup>2</sup>as well as man.<sup>3</sup>The difference in part may be due to the lower mean arterial pressure obtained with external cardiac massage. With cardiac arrest and cessation of circulation, there is a sudden rise of venous pressure and a similar fall in arterial pressure so that the two equilibrate at 20 to 25 mm Hg.<sup>1</sup>If cardiac output is to follow traditional pressure flow relationships (flow = pressure/resistance) the mean arterial pressure must be higher than 25
Limitations on Dose Estimation
Authors: Nurtan A. Esmen
Journal: Environmental Health Perspectives (1981)

The process of estimation of dose at a target organ from the measurements of environmental concentration of potentially hazardous agents is theoretically examined. The analysis of the estimation process suggests that the design of any study which aims to find the health effects of an agent or to construct a dose-response relationship from environmental measurements must be fully scrutinized to see whether a representative dose is tractable from such measurements made on the agent or extrapolation from a set of known effects at high dose levels is feasible and desirable.