tbuckley/cabot-search huggingface dataset:
Antihypertensive actions of diuretics. Comparative study of an aldosterone antagonist and a thiazide, alone and together
Authors: B. M. Winer
Journal: JAMA (1968)

Hydrochlorothiazide in a daily dose of 150 mg and spironolactone in a daily dose of 400 mg (100 mg of the currently available preparation) were found to have equivalent antihypertensive effects—reducing basal blood pressure, decreasing the pressor response to levarterenol bitartrate (norepinephrine) and angiotensin amide, and increasing the depressor response to a ganglion-blocking agent, trimethaphan camsylate—in a double-blind study of 11 hypertensive patients. The two diuretics, when given together, appear to act independently and additively in their antihypertensive effects. Serum potassium level, lowered by hydrochlorothiazide, was in the normal range during administration of spironolactone alone or in combination with hydrochlorothiazide. Spironolactone can thus be a useful substitute for a benzothiadiazine derivative in the treatment of hypertension. The administration of a combination of these diuretics, a thiazide and an aldosterone antagonist, can render hypertension more readily manageable.
Reply
Authors: Kristian Harms, Gunter Flemming
Journal: Hepatology (2019)

Potential conflict of interest: Nothing to report. Many thanks to Mauro Pantheghini and Ferruccio Ceriotti for raising important analytical issues regarding the standardization of laboratory tests. Measurements of serum enzymes are among the 20 most frequently ordered tests in clinical laboratories.1 Current participation reports for external quality assessment schemes (EQAS) show that the assays (Roche Diagnostics) used for our study2 are used widely in Germany and account for approximately 50% of EQAS participants for aspartate aminotransferase (AST), alanine aminotransferase (ALT), and gamma‐glutamyltransferase (GGT). For our study, these assays were implemented on only one platform (cobas analyzer; Roche Diagnostics, Risch‐Rotkreuz, Switzerland), and no other assays or manufacturers were used. AST and ALT assays included the addition of pyridoxal‐5‐phosphate, as required for standardization by the International Federation of Clinical Chemistry and Laboratory Medicine. Analytical performance of all assays was evaluated in accordance with the current "Guidelines of the German Medical Association on Quality Assurance in Medical Laboratory Examinations" (Rili‐BÄK), which define the minimum requirements for internal and external quality assessment of quantitative measurements.3 The maximum allowable EQAS deviation is provided by Rili‐BÄK, and EQAS target values for ALT, AST, and GGT are reference method values.3 EQAS limits according to Rili‐BÄK were never violated during the entire study period. The root mean square of measurement deviations (RMSMDs, indicating imprecision and bias) always fulfilled the Rili‐BÄK requirements for internal quality assessment. Exemplary data (high/low control) from the middle of the study period, representative for the entire study period, showed interassay coefficients of variation (indicating imprecision) of 1.9%/2.2% (ALT), 1.7%/3.0% (AST) and 1.1%/2.3% (GGT), and RMSMDs of 2.7%/2.4% (ALT), 3.2%/4.6% (AST) and 2.6%/3.1% (GGT), respectively. Hence, we agree that measurements of enzyme concentrations should not ignore the type of method used, but we insist that our study fulfills the necessary standardization and quality assessment requirements. Furthermore, the focus of our work was not methodology, but to clarify the effects of sex, age, body mass index, and puberty on ALT, AST, and GGT enzyme levels.2 We completely agree that legislation shortcomings, manufacturing limitations, and lack of a proactive role of laboratory professionals to abandon nonstandardized assays are the most significant issues.1 Additionally, if laboratory professionals manage to sensitize clinicians to the clinical relevance of laboratory test standardization, clinicians themselves might become keener to ask for standardized assays as an inevitable requirement for optimal patient care and clinical guidelines.
Ventricular Fibrillation
Authors: Paul F. Cranefield
Journal: New England Journal of Medicine (1973)

THE normal contraction of the ventricles is excited by the propagation throughout the myocardial cells of an action potential that arises in the sinoatrial node, travels through atrial fibers to the atrioventricular node, conducts slowly through the atrioventricular node, and reaches the ventricular myocardium via the bundle of His and the Purkinje fibers of the ventricular conducting system. This sequence leads to the co-ordinated contraction that is responsible for the ejection of blood from the ventricles into the pulmonary artery and aorta.If portions of the ventricle contract while other parts are relaxed, the relaxed parts stretch or distend so . . .
AXL-expressing homeostatic liver macrophages are reduced in patients with progression of cirrhosis
Authors: Oltin-Tiberiu Pop, Robert G. Brenig, Evangelos Triantafyllou, Anne Geng, Arjuna Singanayagam, Patrizia Kuenzler, Petr Hruz, Julia Wendon, Jan Hendrik Niess, Markus Heim, David Semela, Harry Antoniades, Lucia Possamai, Luigi Maria Terracciano, Christine Bernsmeier
Journal: Journal of Hepatology (2020)
LETTER FROM PARIS.
Authors: None A, B.
Journal: JAMA (1890)

<h3>(FROM OUR REGULAR CORRESPONDENT.)</h3> <i>One of the Causes of non-success observed after Laparotomy performed for Internal Strangulation — Treatment of the Congestive states of the Brain —Autographism—Cure of a Case of Traumatic Tetanus—Chloroform Vapor as an Antiseptic</i>. In a communication made by Dr. Duret to the Congress of French Surgery on the utility of washing out the stomach in the cases of laparotomy for internal strangulation, the author pointed out that as a principle, one of the causes of non-success observed after laparotomy performed for internal strangulation, was the defect of intestinal antisepsis. The septic liquids of the digestive tube transude into the peritoneum. In support of the preceding doctrine, the author communicated the following case: A man, æt. 57 years, presenting all the signs of internal strangulation, such as fæcaloid vomiting, meteorism and hypothermia. The strangulation had commenced four days previously, and futile attempts had been made to
Anesthesiology
Authors: R. A. Wiklund
Journal: JAMA (1994)

Health care system reform calls for providing patients with cost-effective care in settings as diverse as the ambulatory surgical unit or the intensive care unit. Senator John D. Rockefeller IV<sup>1</sup>applauds the efforts of Johnstone and Martinec<sup>2</sup>as groundbreaking work that allows us to understand the true costs of anesthesia services. By organizing and defining the components and determinants of anesthesia costs, these investigators from West Virginia University, Morgantown, draw attention to the fact that anesthesia providers control at least 3% to 5% of total annual health care costs in the United States—$9 billion for provider services and $11.7 billion for preoperative testing. The Committee on Professional Liability of the American Society of Anesthesiologists has undertaken an initiative to reduce health care costs related to professional liability.<sup>3</sup>Their comparison of pediatric and adult anesthesia closed malpractice cases shows substantial differences. Mishaps with inadequate ventilation occurred more frequently
THE NEWSPAPER AS A PATHOLOGICAL FACTOR.THE USE OF SUGAR.
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Emergency!
Authors: Malinda H. Bell
Journal: JAMA (1990)

<i>Emergency!</i>has all the sensationalism of a supermarket tabloid—sex, violence, blood—even an exclamatory title. It reflects the collaborative efforts of a former emergency department (ED) administrator at a New York City medical center, now head of her own public relations firm, with a soap opera actress. Most scenarios have an artificial "made for TV" quality. The characters are flat but oh-so-glib. A couple making love on a gurney are overheard to say, "Giddyap! Hi ho, Silver!" A transient smelling like "overripe Camembert cheese" is taken to a shower for delousing and breaks into a chorus of "Singin' in the Rain," and the nursing aide joins in. An actor presents with a scalp laceration, and Shohen quips, "There is certainly more than one way to let an actor know that you don't like the performance." Although perhaps they were intended as entertainment, my staff and I found such passages heavy-handed and
A STUDY OF MALNUTRITION OF SCHOOLCHILDREN
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The King
Authors: M. Therese Southgate
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
HCV pathogenesis
Journal: Hepatology (2013)

development.In this study, we sought to evaluate the association of expression patterns of SYK(L) and SYK(S) with prognosis in HCC, and to explore the biological effect of SYK isoforms on HCC.Methods: We used qPCR, immunoblotting and immunohistochemistry to study the expression levels of SYK(L) and SYK(S) in human HCC tissue and hepatoma cell lines.The expression levels of SYK(L) and SYK(S) in HCC specimens was compared with clinicopathologic variables and patient survival information.Matrigel assay and orthotopic animal models of athymic mice were used to evaluate the effect of SYK on metastasis in vitro and in vivo, respectively.Results: SYK(L) was downregulated in 38% (58/152), and SYK(S) was detectable in 40% (61/152) of the HCC samples but not in normal liver tissue samples without cirrhosis (0/30).SYK(S) was significantly correlated with pathological parameters characteristic of tumor metastasis, including multiple tumors (P=0.003),absent or incomplete tumor capsule (P=0.041) and vascular invasion (P=0.001).Expression of SYK(S) promoted tumor growth, and suppressed apoptosis of HCC cells, phenotypes that opposed those induced by SYK(L).Expression of SYK(L) significantly decreased the number of metastatic foci in lung (P=0.004) in athymic mice.In contrast, SYK(S) increased the number of lung metastases (P=0.017).In human clinical specimens (n=152), SYK(S) expression significantly correlated (P=0.002) with the reduction of E-cadherin, a hallmark of epithelial-mesenchymal transition (EMT) associated with HCC metastasis.In contrast, there was no significant association between SYK(L) and E-cadherin (P=0.869).The patients with SYK(L+/S-) tumors had a significantly longer overall survival (OS) and time to recurrence (TTR) than those with SYK(L-/S-) or SYK(L+/S+) tumors (P <0.001).Multivariate analyses showed that among all factors associated with TTR and OS, decreased SYK(L) and presence of SYK(S) expression were the two most powerful independent prognostic markers.Conclusions: Our results suggest that SYK(S) enhances HCC tumor invasion through induction of EMT.However, SYK(L) inhibits HCC metastasis.Down-regulated SYK(L) or added SYK(S) expression are strong predictors of poor survival in HCC patients, indicative of the possible need for aggressive therapeutic intervention.
Targeting NEK2 attenuates glioblastoma growth and radioresistance by destabilizing histone methyltransferase EZH2
Authors: Jia Wang, Peng Cheng, Marat S. Pavlyukov, Hai Yu, Zhuo Zhang, Sung-Hak Kim, Mutsuko Minata, Ahmed Mohyeldin, Wanfu Xie, Dongquan Chen, Violaine Goidts, Brendan Frett, Wenhao Hu, Hongyu Li, Yong Jae Shin, Yeri Lee, Do-Hyun Nam, Harley I. Kornblum, Maode Wang, Ichiro Nakano
Journal: Journal of Clinical Investigation (2020)
Description: Gram-Negative Pneumonia
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Highlights
Journal: JAMA Pediatrics (2016)

In this population-based study in Norway, Berg and coauthors follow up 2337 patients with cleft lip only, cleft palate only, and cleft lip and palate until they reached 18 years of age.No increased risk for morbidity or mortality was found for individuals with isolated cleft palate only, while patients with both cleft lip and palate were at increased risk for intellectual disability and cerebral palsy.Those with cleft palate only had the greatest risk for intellectual and motor disorders as well as a 3.4 increased risk for mortality.Heike and Evans discuss the implications for craniofacial disease research.
In This Issue of JAMA Neurology
Journal: JAMA Neurology (2013)

F-Box Only Protein 7 Gene in Parkinsonian-Pyramidal Disease D eng and colleagues (page 20) provide a sys- tematic review of the clinical, pathological, and genetic features of parkinsonianpyramidal disease and explore the pathogenic relationship between parkinsonian-pyramidal disease and the FBXO7 gene.
HIDRADENOID VESTIBULOACANTHOMA.
Authors: J. L. S. SMITH, J. G. COBURN
Journal: British Journal of Dermatology (1957)

Journal Article HIDRADENOID VESTIBULOACANTHOMA. Get access J. L. S. SMITH, M.D.(Cantab.), D.O.M.S., J. L. S. SMITH, M.D.(Cantab.), D.O.M.S. Lecturer in Ophthalmic Pathology, University of Manchester Search for other works by this author on: Oxford Academic Google Scholar J. G. COBURN, M.D.(Manch.) J. G. COBURN, M.D.(Manch.) Dermatologist, Manchester and Salford Hospital for Skin Diseases, Assistant Lecturer in Dermatological Histopathology, University of Manchester Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 69, Issue 12, 1 December 1957, Pages 428–442, https://doi.org/10.1111/j.1365-2133.1957.tb13217.x Published: 01 December 1957
Re: Johann S. de Bono, Matthew R. Smith, Fred Saad, et al. Subsequent Chemotherapy and Treatment Patterns After Abiraterone Acetate in Patients with Metastatic Castration-resistant Prostate Cancer: Post Hoc Analysis of COU-AA-302. Eur Urol. In press. http://dx.doi.org/10.1016/j.eururo.2016.06.033
Authors: Giandomenico Roviello, Daniele Generali, Roberto Petrioli
Journal: European Urology (2016)
Abstract 1126: Association of CXCR4 expression with lymph node metastasis in distal cholangiocarcinoma
Authors: Yohsuke Yagawa, Atsushi Aruga, Nobuhiro Takeshita, Ryota Higuchi, Takehisa Yazawa, Keishi Tanigawa, Masakazu Yamamoto
Journal: Cancer Research (2019)

Abstract BACKGROUND: The standard treatment of resectable distal bile duct cancer is pancreatoduodenectomy. However, prognosis is still poor because of a high rate of lymph node (LN) metastasis, underlining the need to further clarify the mechanism of LN metastasis. Recently accumulated evidence has shown that cancer cells can take advantage of the homeostatic mechanism of lymphocyte homing to metastasize to LNs. The CXCL12-CXCR4 axis modulates lymphocyte homing by inducing continuous migration of dendritic cells and T cells that are expressing chemokine receptor CXCR4 to LNs where chemokine CXCL12 is homeostatically secreted. OBJECTIVE: The aim of this study is to elucidate whether distal bile duct cancer cells express CXCR4 and investigate a possible association with LN metastasis. METHODS: This study enrolled 32 patients with resectable distal bile duct cancer including 19 patients with LN metastasis and 13 without. All patients underwent pancreatoduodenectomy at our department between 2002 and 2008 and have been followed up (Median observation period: 50.5 (4-184) months). Histopathologically, 27 cases were tubular adenocarcinoma, and 5 cases were other types of cancer. Immunostaining with resected specimens was undertaken to examine the expression of CXCR4 in cancer cells and determine whether its expression level is associated with lymph node metastasis. When 10% and more of tumor cells were stained, specimens were diagnosed as positive for CXCR4. The result of staining level was visually assessed. RESULTS: Cancer cells were stained heterogeneously by antibody for CXCR4. Normal cells of the bile duct were not stained, while damaged or desquamated cells were stained. With regard to the staining pattern, the cytoplasm and membrane were stained but the nucleus was not stained. 19 out of 32 cases were positive for CXCR4 expression (59.4%). 15 of 19 cases with LN metastasis were positive whereas 4 of 13 cases without LN metastasis were positive (p=0.0107). CXCR4 expression on cancer cells increased with advancing cancer cell undifferentiation in tubular adenocarcinoma; cancer cells were positive for CXCR4 in 0 of 5 (0%), 6 of 16 (37.5%), and 6 of 6 (100%) cases in tubular 1, tubular 2, and tubular 3 adenocarcinoma, respectively. CONCLUSIONS: Our results indicated that the expression of CXCR4 in cancer cells may be associated with LN metastasis in distal bile duct cancer. Citation Format: Yohsuke Yagawa, Atsushi Aruga, Nobuhiro Takeshita, Ryota Higuchi, Takehisa Yazawa, Keishi Tanigawa, Masakazu Yamamoto. Association of CXCR4 expression with lymph node metastasis in distal cholangiocarcinoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1126.
Experientia con le Empleo Temporari de un Electrodo Intravenose in le Tractamento de Blocco Cardiac
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
虹膜色素病变作为皮肤黑色素瘤风险的标志物:澳大利亚病例对照研究
Authors: A.M. Laino, E.G. Berry, K. Jagirdar, K.J. Lee, D.L. Duffy, H.P. Soyer, R.A. Sturm
Journal: British Journal of Dermatology (2018)

早期诊断皮肤黑色素瘤可提高治愈和存活几率。临床医生需要了解高风险患者(例如有多颗痣的患者),才能在早期检测出黑色素瘤。色素痣和斑点状病变在虹膜中很常见,也就是瞳孔周围的有色部分。色素虹膜病变与发育异常的皮肤痣相关,即看似异常、但无癌性的痣,但是与皮肤癌的关联尚未得到证实。作者们主要居住在澳大利亚布里斯班,旨在确定虹膜色素病变是否是黑色素瘤的风险因子。他们检查了1117名确诊黑色素瘤的皮肤病患者以及对照对象(无黑色素瘤),并采集了患者眼部的数码照片。他们发现,40岁以下有三个或三个以上虹膜色素病变的患者患黑色素瘤的几率高45%;该数据未计算黑色素瘤的其他风险因子。他们得出结论,多片区域的虹膜色素沉积对于欧洲人来说是黑色素瘤的风险因子。