tbuckley/cabot-search huggingface dataset:
Absence of the canalicular isoform of theMRP gene-encoded conjugate export pump from the hepatocytes in Dubin-Johnson syndrome
Authors: J Kartenbeck, U Leuschner, R Mayer, D Keppler
Journal: Hepatology (1996)

The Dubin-Johnson syndrome is characterized by an inherited defect in the secretion of amphiphilic anionic conjugates from hepatocytes into the bile. We have recently identified the membrane protein mediating the adenosine triphosphate (ATP)-dependent transport of glutathione and glucuronate conjugates as a multidrug-resistance protein ( MRP ) and localized it to the canalicular as well as to the lateral hepatocyte plasma membrane. In the present study we show the selective absence of the canalicular isoform of MRP (c MRP ) from the hepatocytes in a patient with Dubin-Johnson syndrome by double-label immunofluorescence and confocal laser scanning microscopy using antibodies directed against MRP and dipeptidyl-peptidase IV (DPPIV). Another isoform of MRP was detected, however, in the lateral hepatocyte membrane of the patient. Moreover, MRP was present on immunoblots of erythrocyte membranes from Dubin-Johnson syndrome and normal humans. These findings are analogous to our recent observations on the localization of the rat homolog of MRP and its canalicular isoform, c MRP , in normal and transport- deficient GY/TR- Wistar rat liver. The elucidation of the selective absence of an isoform of MRP and from the canalicular membrane domain in conjunction with the defined substrate specificity of the MRP and c MRP gene-encoded conjugate export pumps contributes to the molecular definition of the transport defect in Dubin-Johnson syndrome.
Correction to: Prognostic impact of immune gene expression signature and tumor infiltrating immune cells in localized clear cell renal cell carcinoma
Authors: Pooja Ghatalia, Jennifer Gordetsky, Fengshen Kuo, Essel Dulaimi, Kathy Q. Cai, Karthik Devarajan, Sejong Bae, Gurudatta Naik, Timothy A. Chan, Robert Uzzo, A. Ari Hakimi, Guru Sonpavde, Elizabeth Plimack
Journal: Journal for ImmunoTherapy of Cancer (2019)

Following publication of the original article [1], the author reported that the current funding section "Kidney Cancer Association Young Investigator Grant provided funding for this project" should be replaced with "Kidney Cancer Association Young Investigator Grant and Bucks County Board provided funding for this project."
Gastroduodenal free papers 026-032
Authors: S Parry, J Barton, M Welfare, I Mohammed, L Cherkas, S Riley, T Spector, N Trudgill, S Lal, J Mclaughlin, G Giampaolo, G Dockray, A Varro, D Thompson, J Jones, D Kendall, P Millns, C Hawkey, S Dunlop, D Jenkins, R Spiller, L Gregory, L Yaguez, S Coen, E Amaro, S Smale, A Hobson, S Williams, Q Aziz, V Chudleigh, E Brennan, S Tarry, S Myers, S Lewis, G Smith, K Palmer, Z Khan, E Simpson, A Cole, I Macdonald, D Pye, A Austin, J Freeman
Journal: Gut (2002)

Introduction: Previous studies, many uncontrolled, suggest 4 to 32% of people develop irritable bowel syndrome (IBS) after ID.Little information is available on the development of other FGIDs after ID.Aim: To determine if patients with stool culture confirmed bacterial diarrhoea were more likely to develop gut symptoms consistent with a diagnosis of IBS, functional dyspepsia or functional diarrhoea at 3 and 6 month follow up compared with community controls.Methods: A prospective community-based case-control study over one year.Subjects with stool positive bacterial infectious diarrhoea and control subjects from the same primary care practice were invited to participate.The presence or not of IBS, functional dyspepsia or functional diarrhoea was diagnosed at the start and at follow up using self-complete Rome II modular questionnaires.The diagnosis of a baseline FGID excluded subjects from continuing.There were 128 cases and 219 community controls eligible and who consented to participate.Results: At follow up there was a higher incidence of FGIDs in the cases compared with controls, mainly due to a higher incidence of IBS (see table ).There was no difference in the incidence of functional dyspepsia between cases and controls.Conclusions: IBS and functional diarrhoea is diagnosed more frequently in people at three and six-month follow up after an episode of stool positive bacterial diarrhoea compared with community controls despite careful exclusion of people with pre-existing FGIDS and adds further support for the concept of post-infectious IBS.
EFFECTIVE GARBAGE DISPOSAL
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Our Climate. Useful Information Regarding the Climate Between the Rocky Mountains and the Atlantic Coast, with Special Reference to Maryland and Delaware
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Virtual Colonoscopy
Authors: Joseph Ferrucci, Matthew Barish, Richard Choi, Abraham Dachman, Helen Fenlon, Seth Glick, Andrea Laghi, Michael Macari, Martina Morrin, Erik Paulson, Perry J Pickhardt, Jorge Soto, Judy Yee, Michael Zalis
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE PRESIDENT'S ADDRESS.
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Thirteenth International Conference on Brain Tumor Research and Therapy&lt;subtitle&gt;October 4–6, 1999 Sapporo, Japan&lt;/subtitle&gt;
Journal: Neuro-Oncology (1999)

Numerous growth factors, cytokines and external stimuli use MAP kinase modules to transduce signals through the cytoplasm.It has been frequently shown that the ERK family of MAP kinases is involved in promoting cell growth while the c-Jun N-terminal kinase (JNK) family is involved in promoting apoptosis.We analyzed a series of glioblastomas (GBM) and anaplastic astrocytomas (AA) using antibodies that recognize the activated forms of these proteins.Surprisingly, Western blot analysis showed that 12/12 GBM and 10/10 AA tumors revealed JNK activation whereas only 2/12 GBM and 2/10 AA tumors had ERK activation.Immunohistochemistry showed that cells with active JNK were not undergoing apoptosis.Analysis of glioma cell lines showed that 4 lines had elevated basal JNK activity but none contained elevated basal ERK activity.10/13 lines showed strong EGF-induced activation of JNK, but normal human astrocyte cell lines did not.This effect was largely specific for EGF as insulin, IGF-1, PDGF, LPA, thrombin and TNF-a produced no or modest JNK activation.EGF has been shown to activate ERK in virtually all cell lines, but 2 GBM lines did not show activation.We hypothesized that JNK may actually contribute to the pathogenesis of these tumors.The U87 and 17280 cell lines were transfected with W.t. JNK, a dominant negative mutant of JNK (dnJNK) and plasmid controls.JNK did not appear to contribute to cell growth; however, dnJNK did strongly suppress soft agar colony formation for both cell lines.Moreover, dnJNK enhanced cisplatin induced apoptosis in the U87 cell line and both cisplatin and serum deprivation induced apoptosis in the 17280 cell line.We conclude that elevated JNK activity contributes to the pathogenesis of gliomas, perhaps through stimulation by EGF, and that inhibition of JNK may be a viable anti-tumor strategy.
Incorrect Data in Table Footnote and Text
Authors: Greta Massetti, William Dietz, Lisa Richardson
Journal: JAMA (2018)

David Meier, MD; Tinh-Hai Collet, MD; Isabella Locatelli, PhD; Jacques Cornuz, MD, MPH; Bengt Kayser, MD, PhD; David L. Simel, MD, MHS; Claudio Sartori, MD
"BAKING POWDER."
Authors: T. F. Leech
Journal: JAMA (1884)

Crawfordsville, Ind., Jan. 15, 1884. Editor Journal of the American Medical Association: In my letter, so kindly published in your issue of January 5, an unimportant error crept in, where you say " his coat" instead of "<i>the cord</i>," in the sentence " The doctor pulled his coat off." In reading<i>The Western Journal of Medicine and Surgery</i>, of March 1, 1847, edited by Drs. Daniel Drake, L. P. Yandell, and T. W. Colescott, I was interested to see what was expected of our Association as set forth in the following extracts: "Provided its members shall consult together with a fixed determination not to part till they have laid the foundation of an American profession. It is quite time that this was at least attempted. At present there is as little intercourse and sympathy between the physicians of the different States of the<i>Union</i>, so-called, as between those of the different kingdoms
Health-Related Quality of Life—Puerto Rico, 1996-2000
Journal: JAMA (2002)

Although a number of studies have been made to determine the health-related quality of life (HRQOL) of persons living in the United States, no overall assessment of HRQOL has been conducted previously for residents of Puerto Rico. To determine the HRQOL of adults living in Puerto Rico, during 1996-2000, as part of the Behavioral Risk Factor Surveillance System (BRFSS), interviews were conducted in Spanish with a representative sample of Puerto Rican adults. Older women, persons with less education or lower income, persons unable to work, and those who were overweight or who had diabetes or high blood pressure reported more days for which they were physically or mentally unhealthy during the 30 days preceding the survey. Interventions designed to reach these vulnerable, demographic, socioeconomic, and behavioral risk groups might help adults in Puerto Rico increase their quality and years of healthy life and eliminate health disparities.
PTH-075 Predictors of Post-Operative Recurrence of Ileal Crohn’s Disease
Authors: MN Quraishi, M Widlak, N Bhala, N Sharma, TH Iqbal
Journal: Gut (2016)

<h3>Introduction</h3> Long term follow up of patients resected for ileal Crohn’s (IC) disease have reported recurrence rates to range from 10–30% during the first post-operative year. Recent randomised controlled trials have shown that the “treat to target” approach based early colonoscopy to detect and treat early recurrence is crucial in maintaining remission. This study aims to identify clinical factors that predict risk of recurrence to help stratify patients that warrant early colonoscopy. <h3>Methods</h3> In a retrospective study conducted in a University Hospital with a catchment area of 1 million patients, clinical records of patients with Crohn’s disease under regular follow-up from January 2011 to November 2013 were reviewed to identify patients who underwent ileal resection. The outcome after surgery was assessed on the basis of electronic patient records that were prospectively followed up till November 2015. <h3>Results</h3> 50 patients were included in this study (median age: 34 years, male: 21 (42%)). The median duration of postoperative follow-up was 22 months. 26 (52%) patients had endoscopic or radiological evidence of recurrent disease. Probabilities of recurrence according to the Kaplan-Meier method were 22% and 41% at 1 and 2 years respectively. Univariate analysis (log-rank) showed that pre-operative dual immunosuppression with immunomodulatory and biological agents (p = 0.01), lack of response pre-operatively to at least two biological agents (p = 0.01) and previous surgery (p = 0.02) were associated with increased risk of recurrence of IC disease. Multivariate Cox hazard model demonstrated that fibrostenotic or fistulating/penetrating disease (HR = 3.55; 95% CI 1.24 to 10.19; p = 0.02), perianal disease (HR = 2.41; 95% CI 1.02 to 5.66; p = 0.04) and smoking (HR = 2.92; 95% CI 1.18 to 7.22; p = 0.02) significantly increased risk of recurrence post ileal resection and were independent predictors of relapse. Older age at diagnosis non-significantly reduced the risk of post-operative recurrence of IC disease (HR = 0.53; 95% CI 0.25 to 1.09; p = 0.086). <h3>Conclusion</h3> In addition to known risk factors we have shown that patients on dual immunosuppression and failure of two biologics pre-operatively are significant factors in predicting early recurrence. In the era of “treat to target” approach to achieve mucosal healing and sustained remission, risk stratification based on strong clinical predictors of early post-operative recurrence of Crohn’s disease will help guide timing of colonoscopy following surgery. <h3>Disclosure of Interest</h3> None Declared
18-Hydroxy-Deoxycorticosterone in Human Hypertension
Authors: JAMES C. MELBY, SIDNEY L. DALE, THOMAS E. WILSON
Journal: Circulation Research (1971)

18-Hydroxy-ll-deoxycorticosterone (18-OH-DOC) was isolated from human adrenal vein blood in concentrations of the same magnitude as is aldosterone, and its structure was proved by a variety of methods including mass spectral analysis. Angiotensin infusions failed to evoke a rise in 18-OH-DOC secretion, whereas ACTH increased 18-OH-DOC secretion up to 20-fold. The secretion rate of 18-OH-DOC determined by isotope dilution in healthy subjects was similar to the range of aldosterone secretion. Excretion of the ring A reduced glucuronide metabolite, 18-hydroxy-tetrahydro-deoxycorticosterone (18-OH-TH DOC), in urine proved to be a valid index of secretion of 18-OH-DOC. 18-OH-DOC secretion was estimated in a variety of hypertensive disorders and found to be significantly elevated in a few (3 of 12) patients with essential hypertension, suppressed plasma renin activity, low or normal aldosterone secretion, and who had significant reduction in blood pressure with spironolactone. A single patient became normotensive on prolonged dexamethasone suppression of ACTH and 18-OH-DOC secretion. The possibility that 18-OH-DOC is a precursor of some more oxygenated and, perhaps, more active mineralocorticoid is suggested.
Annual Reprint of the Reports of the Council on Pharmacy and Chemistry of the American Medical Association for 1929.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reply
Authors: A. PAGANINI-HILL, R. K. ROSS, B. E. HENDERSON
Journal: JNCI Journal of the National Cancer Institute (1988)

Journal Article Reply Get access ANNLIA PAGANINI-HILL, ANNLIA PAGANINI-HILL Department of Preventive Medicine, University of Southern California School of Medicine1441 Eastlake Avenue #802, Los Angeles, CA 90033 Search for other works by this author on: Oxford Academic PubMed Google Scholar RONALD K. ROSS, RONALD K. ROSS Department of Preventive Medicine, University of Southern California School of Medicine1441 Eastlake Avenue #802, Los Angeles, CA 90033 Search for other works by this author on: Oxford Academic PubMed Google Scholar BRIAN E. HENDERSON BRIAN E. HENDERSON Department of Preventive Medicine, University of Southern California School of Medicine1441 Eastlake Avenue #802, Los Angeles, CA 90033 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 80, Issue 2, 16 March 1988, Page 76, https://doi.org/10.1093/jnci/80.2.76-a Published: 16 March 1988
THE TREATMENT OF ACUTE ANÆMIA.
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
LETTER FROM NEW YORK.
Authors: None P. B. P.
Journal: JAMA (1889)

Dr. Jacobi reads some Notes on the Baking of Bacilli, at the Academy of Medicine—Dr. John C. Peters reports for the Committee on Croton Water Nuisances—Mr. R. H. Robertson exhibits and describes the plans of the New Academy Building—Commencement Exercises at the College of Physicians and Surgeons—The Presidency of the Board of Health—The Election of Dr. E. M. Moore, of Rochester, N. Y., as President of the American Medical Association, received with enthusiasm. It was not expected that there would be any scientific exercises at the last meeting of the Academy of Medicine before the summer vacation, but on account of special circumstances and the importance of the subject, Dr. Jacobi was given the privilege of reading some "Notes on the Baking of Bacilli." It will perhaps be remembered, in this connection, that a few months ago Dr. Louis Weigert's hot air inhalation apparatus was exhibited at a meeting
Recurrent Urinary Tract Infections
Authors: Kenneth L. Vosti
Journal: JAMA (1975)

Fourteen patients with chronic or multiple recurrences of infection of the urinary tract have self-administered a single oral dose of one of five antibiotics after sexual intercourse for periods of 19 to 111 months for a total of 761 months. Infections did not occur among 15 of 22 treatment periods. A total of 19 infections occurred while the patients were taking prophylactic medication, significantly less than the total of 90 infections recorded during the 705 months when these patients did not take prophylactic doses of antibiotics. Patients taking nitrofurantoin, a cephalosporin, or nalidixic acid had a significant reduction in the proportion of specimens of urine containing any Gram-negative bacteria. Serious toxic effects were not encountered. (<i>JAMA</i>231:934-940, 1975)