tbuckley/cabot-search huggingface dataset:
Cephalothin-induced tachycardia following aortic valve replacement
Authors: G. M. Lemole
Journal: JAMA (1972)

Prophylactic antibiotics, though routinely used by most surgeons for patients undergoing open-heart surgery, are of questionable value and may cause serious side effects. Cephalothin-sodium-induced tachycardia accompanied by hemolysis and hyperpyrexia presents problems of diagnosis. The reported patient's survival is attributed to discontinuation of the drug.
Hypermagnesemia following irrigation of renal pelvis. Cause of respiratory depression
Authors: D. B. Jenny
Journal: JAMA (1978)

HYPERMAGNESEMIA is most commonly associated with renal insufficiency or an exogenous source of magnesium.<sup>1</sup>Although magnesium-containing antacids and cathartics constitute the most common source of exogenous magnesium,<sup>2</sup>urologic irrigation solutions, used for the dissolution of urinary calculi, may also contain magnesium.<sup>3</sup>While modest elevations in serum magnesium have been described with the use of such irrigation solutions,<sup>4</sup>elevations of this ion sufficient to cause respiratory paralysis have, to our knowledge, not been previously reported. We treated such a patient. <h3>Report of a Case</h3> A 35-year-old man, paraplegic as a result of a thoracolumbar menigomyelocele, was admitted to St Joseph Hospital on Aug 3, 1977, for evaluation of fever and foul-smelling urine of 24 hours' duration. The patient had a chronic suprapubic catheter and in the past had had numerous episodes of urinary tract infections associated with right renal calculi and mild chronic renal insufficiency. There was no
Take two aspirin and see me in the macrocosm
Journal: JAMA (1980)

WHILE looking over the shoulder of my seatmate on a crowded bus this morning, I noticed an article in the<i>Chicago Sun-Times</i>. Elliot M. Estes, president of General Motors Corp, was quoted as saying that the current economic problems we are experiencing in this country are just a "hiccup" in the long-term health of the economy. It should be mentioned, I suppose, that this speech was made in Sao Paulo, Brazil. Presumably, Mr Estes chooses to be out of the country while it is hiccuping. I was delighted to hear our country's problems described in these terms, since, as a physician, this is a form in which I can address them. It is well known that a hiccup, or more formally singultus, is "A diaphragmatic spasm causing a sudden inhalation which is interrupted by the spasmodic closure of the glottis, producing a noise." That there is an analogy between our
Corrigendum
Journal: British Journal of Dermatology (2011)

The authors would like to make a correction to the letter 'Melanotan associated melanoma' 1 recently published in the Journal.The terms melanotan, melanotropic peptides, afamelanotide, and alpha -MSH analogues are commonly intermingled in scientific publications and used without distinction.On this account we have inadvertently and involuntarily used the term afamelanotide in the description of the other case reports on melanoma.It has to be stressed out that all of these cases were linked to injections of substances of uncontrolled and non-approved sources and that none of these cases was associated with afamelanotide (Sce-nesse°, controlled-release formulation, 16 mg; Clinuvel Pharmaceuticals Ltd, Melbourne, Vic., Australia), regulated by EMA and FDA, and currently under investigation for the prevention of actinic damage, photodermatoses, erythropoietic protoporphyria and solar urticaria.
Envoi
Authors: Ted McMahon
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical advances in pediatric hepatology
Authors: Julie Venter, Laura Hargrove, Sharon Demorrow, Kelly Mcdaniel, Micheleine Guerrier, Marco Marzioni, Gabriel Frampton, Holly Standeford, Eugenio Gaudio, Paolo Onori, Debolina Ray, Shannon Glaser, Fanyin Meng, Heather Francis, Gianfranco Alpini
Journal: Hepatology (2013)

Cholangiocytes, which line the intrahepatic and extrahepatic bile ducts, secrete bile and proliferate in response to gastrointestinal hormones such as secretin and somatostatin.While secretin stimulates bile secretion by interacting with secretin receptor (SR) by activating the cAMP⇒PKA⇒CFTR⇒Cl -/HCO 3 -AE2 pathway, somatostatin inhibits secretin-stimulated choleresis by acting on SSTR 2 receptors.Numerous in vitro models are available for studying the function of rodent and human intrahepatic cholangiocytes and gallbladder epithelial cells.However, limited in vitro tools exist for evaluating the pathophysiology of extrahepatic common bile ducts (ECBDs).Aim: To develop a culture system from ECBDs from normal rats.Methods: ECBDs were dissected from normal male Fischer 344 rats, cut in half length-wise and cultured on collagen-I coated plates containing DMEM/F12 media with 5% of FBS and 24 ng/ml of EGF.TransEpithelial Electrical Resistance (TEER, an index of cell confluence across the epithelial monolayer) was determined with an EVOM2 epithelial volt-ohm meter.At ~85% confluency, cells were trypsinized before measuring: (i) cell size and distribution by a Cellometer, and expression for CK-19, secretin, SR, SSTR 2 , CFTR, Cl -/HCO 3 -AE2, albumin, VEGF-A/C and NGF (key trophic factors in cholangiocytes) by real-time PCR and/or immunoblots, and immunofluorescence in cell smears; and (ii) the effect of secretin, somatostatin and secretin + somatostatin (all at 100 nM) on cAMP levels by EIA and proliferation (by MTS assays, 100 nM, 1-7 days).Results: ECBDs composed entirely of CK-19-positive cholangiocytes, cultured for 6 passages formed a monolayer of epithelial cells.Passaged cultured ECBDs formed spherical cysts, an indication of water secretion.Cholangiocytes proliferated to confluency over a 2-wk period, as indicated by the TEER value of 195.8±3.54 ohms/cm 2 .The size of ECBDs ranged from 8 to 26 μm, mean diameter ~16 μm.ECBDs were positive for secretin, SR, SSTR 2 , CFTR, Cl -/HCO 3 -AE2, VEGF-A/C and NGF but negative for albumin, a marker of mature hepatocytes.Secretin increased cAMP levels and cell mitosis, increases that were prevented by pre-incubation with somatostatin.Summary/Conclusion.We have developed a culture system of polarized ECBDs displaying morphological, phenotypical and functional features of normal cholangiocytes.This culture system may be key for a better understanding of diseases targeting extrahepatic bile ducts such as primary sclerosing cholangitis and biliary atresia.
2B: H. pylori infection in childhood
Authors: M Ashorn, T Ruuska, M Maid, T Vorobjova, H Grunberg, M Oona, H.-I Maaroos ', T Wadstrom2, R Uibo, Nimish Vakil, F Bazzoli, L Cecchini, L Corvaglia, M Dall'antonia, M Dalla Libera, C De Giacomo4, S Fossi, P Garisio, L Gobbio Casali, S Gullini, R Lazzari, G Leggeri, P Lerro, F Lizzoli, G Mandrioli, M Marani, P Martelli, A Miano, C Mwangemi, G Oderda, A Pasetti, P Pazzi, P Pozzato, L Ricciardiello, E Roda, P Simoni, S Sottili, G Torre, L Urso, R Zagari, Icesena Bologna
Journal: Gut (1996)

The purpose was to study the long-term course of H. pylori infection in children and their parents.Methods: Sera drawn from 14 children born in 1984 with positive IgG-antibody titres to H. pylori in their cord blood samples were sequentially tested at the ages of 28 days and at 7, 12 and 24 mos.In 1995, at the age of 11 yrs, children were re-tested by serology and 13C-urea breath test (UBT).H. pylori antibodies were also determined in the mothers to all children and in the fathers of 11 children.Nine originally seronegative children born in the same year served as controls.The parents of control children were also serologically tested (8 mothers, 4 fathers).An in-house enzyme immunoassay using H. pylori strain ATCC 43504 was applied for antibody determination.For UBT duplicate breath samples were collected before and 30 minutes after administration of '3C-urea for the analysis of 13C02.Results: All 14 originally seropositive children became seronegative till the age of 7 mos.The control visit at the age of 11 yrs revealed recurrent abdominal pain in 14% of these children.Serology was negative as well as the UBT. 12/14 mothers had highly positive IgG antibody titres to H. pylori.5/11 fathers tested were seropositive.Positive history of gi-symptoms was found in 33% of the mothers.In the control group one child was seropositive and also had a positive UBT result.His parents were both seronegative, his grand-mother having, however, H. pylori infection.Conclusions: 1. Maternal seropositivity does not increase the risk of H. pylori infection during childhood. 2. Till the age of 7 mos seropositivity is basicly a reflection of maternal antibody status. 3. Seroreversion from positive to negative is rare, but it seems to occur.
NCCN News
Journal: Journal of the National Comprehensive Cancer Network (2013)

➤ Adding a new iron status: "Absolute iron deficiency (ferritin <30 ng/mL AND TSAT <20%)."➤ Adding to the functional iron deficiency, "in patients receiving ESAs" and revising the parameters from "ferritin ≤800 ng/mL AND TSAT <50%" to "ferritin 30-800 ng/mL AND TSAT 20%-50%."➤ Revising the no iron deficiency status parameters from "ferritin >800 ng/ mL OR TSAT ≥20%" to "ferritin >800 ng/mL OR TSAT ≥50%."Cont. on page xxx.
A pilot study of galunisertib (LY2157299 monohydrate) plus stereotactic body radiotherapy (SBRT) in advanced hepatocellular carcinoma (HCC).
Authors: Kim Anna Reiss, Edgar Ben-Josef, Nevena Damjanov, Maarouf Hoteit, Thomas Benjamin Karasic, Erica Carpenter, Lisa DiCicco, Luis Anna Garcia-Marcano, Rosemarie Mick, Robert H Vonderheide
Journal: Journal of Clinical Oncology (2019)

270 Background: TGF-β, the strongest known immunosuppressive cytokine, modulates the hepatic immune response to various antigens and to ionizing radiation. When activated, TGF-β blocks the effector T-cell response to cellular destruction and the release of tumor-specific antigens. Preclinical data demonstrate that neutralizing TGF-β during radiation effectively generates a CD8+ T-cell response to multiple endogenous tumor antigens, thereby generating an in-situ vaccine against a tumor. We hypothesized that the combination of TGF-β receptor inhibition plus SBRT would produce a potent and clinically effective antitumor immune response against HCC. Methods: Patients received galunisertib (LY2157299 monohydrate) on days 1-14 of each 28 day cycle. SBRT was delivered in a single fraction of 18 Gy between days 15-28 of C1. Pre-treatment and on-treatment biopsies were obtained, as well as serial blood collections for CTCs, ctDNA and PBMCs. Results: 15 patients with advanced HCC and Child’s Pugh A cirrhosis were treated. 9/15 (60%) had a prior history of infectious hepatitis, three of whom had active viremia at time of enrollment. 6/15 (40%) had received prior systemic therapy for HCC and 12/15 (80%) had received prior liver directed therapy. The most common treatment-related toxicities were: fatigue (53%), nausea (47%), increased alkaline phosphatase (33%), abdominal pain (33%), vomiting (20%), decreased white blood cell count (20%). All drug-related toxicities were grade 1 or 2, with the exception of one patient who had grade 3 achalasia, thought possibly to be related to study drug. Median PFS was 3.68mo. There were two confirmed partial responses (PRs) and six additional patients had stable disease (SD) for at least four months, resulting in a disease control rate (DCR) of 53%. Both PRs included shrinkage of lesions that had not been radiated. Translational studies are currently underway. Conclusions: The combination of galunisertib with SBRT in patients with advanced HCC is a well-tolerated regimen. In this small pilot study, we observe a DCR of 53% including two PRs. These results warrant further study of this therapeutic combination in advanced HCC. Clinical trial information: NCT02906397.
ANOTHER "CANCER CURE" LOSING GROUND
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Editorial
Authors: M. J. Janse, R. Coronel, J. M.T. de Bakker, J. W.T. Fiolet, M. M. Levi, T. Opthof, M. Pfaffendorf, A. A.M. Wilde
Journal: Cardiovascular Research (1995)

Journal Article Editorial Get access Michiel J. Janse, Michiel J. Janse Editor-in-Chief Search for other works by this author on: Oxford Academic PubMed Google Scholar Ruben Coronel, Ruben Coronel Associate Editor Search for other works by this author on: Oxford Academic PubMed Google Scholar Jacques M.T. de Bakker, Jacques M.T. de Bakker Associate Editor Search for other works by this author on: Oxford Academic PubMed Google Scholar Jan W.T. Fiolet, Jan W.T. Fiolet Associate Editor Search for other works by this author on: Oxford Academic PubMed Google Scholar Marcel M. Levi, Marcel M. Levi Associate Editor Search for other works by this author on: Oxford Academic PubMed Google Scholar Tobias Opthof, Tobias Opthof Associate Editor Search for other works by this author on: Oxford Academic PubMed Google Scholar Martin Pfaffendorf, Martin Pfaffendorf Associate Editor Search for other works by this author on: Oxford Academic PubMed Google Scholar Arthur A.M. Wilde Arthur A.M. Wilde Associate Editor Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 30, Issue 3, September 1995, Page 315, https://doi.org/10.1016/S0008-6363(95)90135-3 Published: 01 September 1995
Recurrent hyperinfestation with Stronglyloides stercoralis in a renal allograft recipient.
Journal: BMJ (1983)

follow up show only a marginal difference in survival, while those from an incomplete (five year) follow up show a greater difference.It would be interesting to know if the four year difference is statistically significant.We will all wait with interest to see the results of longer, complete, follow up, but in the meantime we must reserve judgment about the impact of chemotherapy on survival in this study.Finally, the point of systemic chemotherapy is to prolong survival by delaying or preventing systemic relapse, which is likely to be fatal.Of course, many patients with local relapse will quickly develop systemic recurrence.The success of chemotherapy will, however, be judged by survival, and it is at least arguable that patients who relapse locally should not be counted as failures unless and until they relapse systemically.The study of Dr Rossi and others has led some groups to believe that they should abandon untreated controls in studies of adjuvant chemotherapy.The data presented do not in our opinion support this point of view, and the incorrect randomisation raises serious questions whether the final results can be accepted unless there is a very large differ- ence in the two groups.
The chronically swollen painful extremity. A detailed study for possible etiological factors
Authors: J. M. Stallworth
Journal: JAMA (1974)

Forty patients with atypical, chronically swollen, painful lower extremities were observed from two to ten years. Most patients had had previous diagnoses of lymphostasis or venostasis. Clinical reevaluation indicated lipedema (painful fat syndrome) as described by Allen and Hines in 1940 and not reported on since. Fourteen patients were selected at random for detailed pathologic and chemical (tissue and serum) examinations as well as flow studies in the lymphatic, venous, and arterial systems. All study results were essentially normal except for chemical examinations. Significant amounts of lipids containing an altered fatty acid pattern were found in plasma and tissue examined by biopsy. (<i>JAMA</i>228:1656-1659, 1974)
Lectures ON THE ANATOMICAL AND PHYSIOLOGICAL PRINCIPLES UNDERLYING THE TREATMENT OF INJURIES TO MUSCLES, BONES, AND JOINTS: Given at the Royal College of Surgeons of England, November-December, 1917
Authors: A. Keith
Journal: BMJ (1917)

IN tlle spring of 1862 John Hilton completed in the tlheatre of this College a series of lectures wlichl, whlen published in a book under the title of Re8t and Paiv, won an endluring place in the minds andIhearts of medical mnen.I have College portrait of hiim to show what-kind of mas gave those lectureslhere fifty-five years ago."Rest and pain" is a title with more than a touch of ronmance in it; it pre- pares you to expect the finely chiselled face of a poet; but; the man who wove those vivid and incisive lectures from materials freshly gathered at-the bedside hadiotlhing the poet about him.His is a flat, rotund, plainly moulded, robust, and honest face.His contemporaries tell us that he had the outward appearanceof a dapper, prosperous city man.There is nothing at of the stuidents cast countenance abouttllis man whose skilful practice we to follow.There is no trace in hiim of the soiety man; he cold-slhouldered alltlle world save the few he selected associates and friends.He could be, a-nd often was, over- bearing, rude, and mordantly sarcastic.But we shall thatlhe faced adversity with a brave heart, asking favour and lhaving no fear of any man, knowing well that lhe lhad tllat to sell wllich the world must buy, not its, but at his price.Having thlus introduced John Hilton wlien he had established for himself a sure place in Britishl surgery, propose now to turn tohIis earlier years, and watcl hiis growth in knowledge.Hun-ter served the apprenticeship to his life's career in the dissecting room; so did John Hilton.Hunter's dissecting room was in Covent-arden;Hilton's lay in the.Borough, beyond, the south London Bridge.In the year 1824, when Hilton, a 17, came.from Chielmsford Grammar School to medical studies, the twin hoppittals of St. Thomas's and Guy's were cheek by jowl in the Boroughi.They a common dissecting room when-Hilton attached himself to Guy's.He was born at Castle Hediugham, in thee tpper reachies of the Colne, in North Essex, as Saxon settlement as is. to be found anywhere in England.He was a Saxon in build of body and in frame of.His people were 'apparently not well off, for 1il ton not afford to pay the surgeon-pupil's fee which would have secured for himu thle privilegess of climbing tp the highest position in his hiospital.Hunter had been dead more
Many brands of cessation plans lure smokers
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
<i>Florence Nightingale and the Doctors</i>
Journal: New England Journal of Medicine (1959)

These collected papers-whose publication was made possible by his admirers and those near and dear to Dandy-bear witness to the truth of an editorial on his death in the Baltimore Sun: 'He had the imaginative genius to conceive new and startling techniques, courage to try them, and skill-the superb skill-to make them successful.' Dandy's work inspired many during his lifetime and afterwards.This work, pu,blished a decade after his death, will inspire and re-inspire many more.It will also ensure that his stature in the field of medicine, great though it is, will grow greater in the perspective of time, and for posterity it will remain a beautiful and lasting memorial to a surgical genius.
Failure of activated prothrombin complex concentrates in a hemophiliac with an anti-factor VIII antibody
Authors: P. M. Blatt
Journal: JAMA (1984)

IN APPROXIMATELY 15% of patients with severe hemophilia A who receive multiple transfusions, anti— factor VIII antibodies develop (C. W. McMillan, MD, S. S. Shapiro, MD, J. Lazerson, MD, unpublished data, 1983). Control of hemorrhagic episodes in these patients is often difficult and unsatisfactory. Various methods of treatment have been developed for such patients.<sup>1,2</sup>Most recently, activated prothrombin complex concentrates (PCCs) have been described as efficacious in controlling hemorrhage in patients with an inhibitor. Two preparations of activated PCC have been developed: Autoplex (anti-inhibitor coagulant complex) and FEIBA (factor eight inhibitor bypassing activity). In published trials, response to treatment with Autoplex for major and minor bleeds ranged from excellent to fair with no treatment failures,<sup>2</sup>while FEIBA was judged to be effective in control of joint and muscle bleeding in 64% of treatment episodes.<sup>3</sup>The purpose of this report is to describe the failure of Autoplex to