tbuckley/cabot-search huggingface dataset:
Managing cancer and living meaningfully (CALM): A randomized controlled trial of a psychological intervention for patients with advanced cancer.
Authors: Gary Rodin, Christopher Lo, Anne Rydall, Rinat Nissim, Carmine Malfitano, Joanna Shnall, Camilla Zimmermann, Sarah Hales
Journal: Journal of Clinical Oncology (2017)

LBA10001 The full, final text of this abstract will be available at abstracts.asco.org at 2:00 PM (EDT) on Friday, June 2, 2017, and in the Annual Meeting Proceedings online supplement to the June 20, 2017, issue of the Journal of Clinical Oncology. Onsite at the Meeting, this abstract will be printed in the Saturday edition of ASCO Daily News.
Alloalbuminemia
Authors: Baruch S. Blumberg
Journal: JAMA (1968)

Alloalbuminemia is a condition in which the individual has an albumin variant different from common albumin (albumin A). Clinical examinations were performed on Naskapi and Montagnais Indians homozygous and heterozygous for an inherited albumin variant, albumin Naskapi, common in several North American Indian tribes but absent in other populations. None of the individuals with albumin Naskapi appears to have clinical or laboratory findings which could be ascribed to alloalbuminemia. Many physiological materials, dyes, and drugs bind to serum albumin, and some of these bind differentially to the albumin variants. This could be of clinical importance in American Indians.
Abstract 21100: Long-Term Clinical Outcomes of Patients With Chronic Kidney Disease and Critical Limb Ischemia Underwent Percutaneous Transluminal Angioplasty
Authors: Seung-Woon Rha, Byoung Geol Choi, Ae-Young Her, Yong Hoon Kim, Se Yeon Choi, Jae Kyeong Byun, Yoonjee Park, Ahmed Mashaly, Won Young Jang, WooHyeun Kim, Jah Yeon Choi, Eun Jin Park, Jin Oh Na, Cheol Ung Choi, Hong Euy Lim, Eung Ju Kim, Chang Gyu Park, Hong Seog Seo, Dong Joo Oh
Journal: Circulation (2017)

Background: Critical limb ischemia (CLI) and chronic kidney disease (CKD) are associated with poor outcomes. We assessed the 5-year clinical outcomes of CKD versus non-CKD patients (pts) with CLI who underwent peripheral transluminal angioplasty (PTA). Methods: A total 765 consecutive CLI pts underwent PTA were analyzed. CKD is defined as either kidney damage or estimating glomerular filtration rate (GFR) &lt; 90 mL/min/m 2 . Kidney damage is defined as pathologic abnormalities or markers of damage, including abnormalities in blood or urine tests or imaging studies. Patients (pts) were divided into two groups according to the presence of CKD (CKD group: 465 pts, non-CKD group: 300 pts). To adjust for any potential confounders that could cause bias, propensity score matching (PSM) analysis was performed. Five-year clinical outcomes were assessed by Kaplan-Meier curved analysis and log rank test. Results: The CKD stage of study populations showed that 42% had mild, 21% moderate, 3% severe, and 32% kidney failure or dialysis. After PSM analysis, two matched groups (226 pairs, n= 452 pts) were generated and their baseline characteristics were balanced. During the 5-year clinical follow-up, there were no differences in the incidence of myocardial infarction, strokes and coronary or peripheral revascularization between the two groups. However, the incidence of total death and the above the ankle amputation were higher in the CKD group than the non-CKD group [Table]. Conclusion: CKD pts with CLI had higher incidence of mortality and amputation rate at 5 years following standard PTA compared with non-CKD pts. Improved therapies and special care are needed for this high-risk group of patients.
Désinfection de dispositifs de ligature de varices œsophagiennes à usage unique: une étude pilote
Journal: Endoscopy (2017)

La ligature élastique, traitement de référence des varices œsophagiennes, est réalisée avec un dispositif à usage unique dont le coût est prohibitif pour les pays de voie de développement. Le but de cette étude était donc d’évaluer l’efficacité d’une désinfection de dispositifs déjà utilisés par culture microbiologique. L’utilité d’une recherche d’adénosine triphosphate en temps réel en remplacement de la mise en culture était évaluée en objectif secondaire.
Implantation: Timing Is Everything
Journal: Environmental Health Perspectives (1999)

More Evidence of Mercury Effects in ChildrenIn research published last summer, scien- tists revealed that prenatal exposure to methylmercury, an organic form of mer- cury that accumulates in animal tissues, may affect the blood pressure and ability to respond to sensory stimuli in exposed children later in life.The team is now also confirming findings of mercury-related neurodevelopmental effects among the Faroese subjects by studying a cohort of Madeiran children.The reports are the latest work of l'hilippe Grandjean, an adjunct professor of public health at Boston University in Massachusetts, and Pal Weihe, medical director of the Faroese Hospital System in T6rshavn, who, with their colleagues, have performed extensive analysis of a longitudi- nal study on the effects of prenatal methylmercury exposure among the inhabitants of the Faroe Islands.The Faroe Islands study was funded by the NIEHS along with European grant-making bodies including the European Commission Environment Research Programme and the Danish Medical Research Council.The Faroese were chosen as study subjects because their diet is rich in pilot whale meat, a prime source of methylmercury.In the study of 917 Faroese children, prenatal exposure to methylmercury was assessed by analyzing mercury concentrations in cord blood and maternal hair.At age 7, the children under- went extensive neurobehavioral testing as well as a general health examination.
The emergent importance of lymphokines
Authors: S. Panem
Journal: JAMA (1983)

Lymphokines? On the cover of<i>TIME</i>? Not yet, but that was the prediction of one participant at the recent Third International Workshop on Lymphokines held at Haverford College outside of Philadelphia. A statement nearly as provocative was made at the conclusion of the multisponsored workshop by one of the organizers, Stanley Cohen, PhD, of the University of Connecticut, Farmington, who predicted that within two years, lymphokines would be used to cure the common cold, cancer, and herpes type 2 infections. What are these substances called lymphokines and why are biotechnology firms planning to invest aggressively and rapidly in their study? The international group of 200 invited participants, about 25% from the commercial sector, had long discussions about the answers. Lymphokines are "regulatory" proteins secreted by lymphocytes. Perhaps the most well-known of these proteins is interferon-γ. Their main function seems to be regulation of the immune response and the growth and
Reply to Vincenza Conteduca, Giorgia Gurioli, and Ugo De Giorgi's Letter to the Editor re: Niven Mehra, David Dolling, Semini Sumanasuriya, et al. Plasma Cell-free DNA Concentration and Outcomes from Taxane Therapy in Metastatic Castration-resistant Prostate Cancer from Two Phase III Trials (FIRSTANA and PROSELICA). Eur Urol. In press. https://doi.org/10.1016/j.eururo.2018.02.013
Authors: Niven Mehra, David Dolling, Johann de Bono
Journal: European Urology (2018)
Dr. A. Signy
Journal: British Journal of Sports Medicine (1972)

came in under the cliff.What luck a fresh frozen lead along the edge!There was an easy ramp off the shelf ice now it was fast flat sea.I dug in the ski sticks and away shot the skis.How effortless.We could easily do twenty miles on this.On the sea I worried about bears.We had no gun.They could be lurking behind floes but fortunately none appeared.Not even a footprint.Ahead was Cape Aldrich.The sun was lost behind the hills.It was after midnight.I began to feel cold, tired and hungry.We traversed on some sloping snow -the skis wanted to run down.It was difficult holding on.
Xylocaine
Authors: C. Grimshaw
Journal: BMJ (1952)

<h3>Background:</h3> Hirschsprung disease (HSCR) is a developmental disorder caused by a defect in the neural crest neuroblast migration process. It is considered to be a paradigm of complex disorders, with many loci contributing to manifestation of the disease. Although HSCR commonly appears as a sporadic trait, ∼20% of HSCR cases are familial, with complex patterns of inheritance. <h3>Method:</h3> A multiplex HSCR family with an additive model of inheritance, in which the contribution of three genes (<i>RET, NTRK3, EDN3</i>) leads to the HSCR phenotype is reported. <h3>Results and discussion:</h3> The findings suggest that both <i>RET</i> and <i>NTRK3</i> mutations acting together are necessary and sufficient for the appearance of the disease, and that the <i>EDN3</i> mutation is acting as a phenotype-modifier factor in the context of this family, as two different HSCR phenotypes are seen among the affected members: a short segment form, and a total colonic aganglionosis. The results therefore support the complex additive model of inheritance previously proposed for Hirschsprung disease.
Problems on Campus
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Role of Interleukin 12 and Costimulators in T Cell Anergy In Vivo
Authors: Luk Van Parijs, Victor L. Perez, Andre Biuckians, Robert G. Maki, Cheryl A. London, Abul K. Abbas
Journal: The Journal of Experimental Medicine (1997)

The induction of T cell anergy in vivo is thought to result from antigen recognition in the absence of co-stimulation and inflammation, and is associated with a block in T cell proliferation and Th1 differentiation. Here we have examined the role of interleukin (IL)-12, a potent inducer of Th1 responses, in regulating this process. T cell tolerance was induced by the administration of protein antigen without adjuvant in normal mice, and in recipients of adoptively transferred T cells from T cell receptor transgenic mice. The administration of IL-12 at the time of tolerance induction stimulates Th1 differentiation, but does not promote antigen-specific T cell proliferation. Conversely, inhibiting CTLA-4 engagement during anergy induction reverses the block in T cell proliferation, but does not promote full Th1 differentiation. T cells exposed to tolerogenic antigen in the presence of both IL-12 and anti–CTLA-4 antibody are not anergized, and behave identically to T cells which have encountered immunogenic antigen. These results suggest that two processes contribute to the induction of anergy in vivo; CTLA-4 engagement, which leads to a block in the ability of T cells to proliferate to antigen, and the absence of a prototypic inflammatory cytokine, IL-12, which prevents the differentiation of T cells into Th1 effector cells. The combination of IL-12 and anti–CTLA-4 antibody is sufficient to convert a normally tolerogenic stimulus to an immunogenic one.
PAINLESS CAPITAL PUNISHMENT.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PHYSICIANS NOT LIABLE WHEN THEY ACT IN GOOD FAITH.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Anesthesia and Analgesia: Current Researches, Cleveland
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Survival rates with coronary artery disease for black women compared with black men
Authors: Y. Liao
Journal: JAMA (1992)

<h3>Objective.</h3> —To evaluate the influence of gender on the prognosis of coronary heart disease among black patients. <h3>Design.</h3> —Cohort study based on a consecutive sample from a hospital registry, with a mean follow-up of 4 years. <h3>Setting.</h3> —An inner-city public hospital in Chicago, III. <h3>Patients.</h3> —The study included 1719 consecutive black patients (780 men and 939 women) who had any one of the following events: cardiac catheterization for presumed coronary heart disease, hospitalization for acute myocardial infarction, or coronary artery bypass grafting. <h3>Results.</h3> —Hospital and operative mortality rates following acute myocardial infarction and coronary artery bypass grafting were similar between the two sexes. The relative risks for cardiac death in women vs men were 0.88 (95% confidence interval [Cl], 0.60 to 1.28), 0.79 (95% Cl, 0.53 to 1.17), and 0.79 (95% Cl, 0.34 to 1.85) for coronary artery disease, acute myocardial infarction, and coronary artery bypass grafting, respectively, after adjusting for age, history of diabetes, hypertension, angina pectoris and myocardial infarction, number of diseased vessels, and ejection fraction. Compared with patients of the same sex with normal angiograms, relative risk estimates were 5.0, 10.1, and 6.3 for women and were 1.8, 4.0, and 2.0 for men in the same three groups of patients, respectively. <h3>Conclusions.</h3> —Survival with coronary artery disease in black women is similar to that observed in black men, but relative to members of the same sex without the disease, the prognosis for women is considerably worse than for men. (<i>JAMA</i>. 1992;268:1867-1871)
Book Review The Therapeutics of Internal Diseases . Supervising editor: George Blumer, M.D. Associate editor: Albert J. Sullivan, M.D. Three volumes. 8°, cloth. Vol. I: 872 pp., 136 illustrations, with 26 tables and 1 chart. Vol. II: 1042 pp., with 2 charts and 14 tables. Vol. III: 738 pp., 39 illustrations, with 1 chart and 2 tables. New York: D. Appleton-Century Company, 1941. Sold only as a set, $40.00.
Journal: New England Journal of Medicine (1942)
The AMA and the Physicians Committee for Responsible Medicine
Authors: N. D. Barnard
Journal: JAMA (1992)

<h3>To the Editor.</h3> —Let me correct a statement in the December 25,1991, issue ofTHE Journal<sup>1</sup>in which Dr Loeb stated that the Physicians Committee for Responsible Medicine (PCRM) had been "officially censured." Censure is used by the American Medical Association (AMA) for specific purposes, and PCRM has never been the subject of any such proceeding. The AMA and PCRM have had strong differences. In 1989, the AMA released its Animal Research Action Plan and has devoted substantial expenditures to pushing animal experimentation. Because PCRM has successfully promoted inquiry into and alternatives to animal experimentation, the AMA is increasingly sniping at PCRM. In 1990, the AMA House of Delegates considered a resolution brought by the California delegation that objected to PCRM for "implying that physicians who support the use of animals in biomedical research are irresponsible, for misrepresenting the critical role animals play in research and teaching, and for
Salicylate Intoxication
Authors: George E. McLaughlin
Journal: JAMA (1965)

<h3>To the Editor:—</h3> The subtle nature of salicylate intoxication was well described by Greer et al (<b>193</b>:555, 1965). The implication, however, that at least two of the five cases (1 and 3) manifested metabolic acidosis does not appear warranted. The authors seem to base this conclusion on the finding of hyperventilation in a patient with low plasma carbon dioxide combining power and an elevated serum salicylate level. In case 5, "surprisingly, acidosis was not present." The above-mentioned triad has trapped many clinicians (including this writer) into a mistaken diagnosis of metabolic acidosis, when in reality it is respiratory alkalosis. The time-honored concept of salicylate pathophysiology discussed by the authors, in which (initial) respiratory alkalosis progresses to metabolic acidosis, does not appear as rational as the "mixed disturbance" pathogenetic view of Winters.<sup>1</sup>In his opinion, a tripartite action of salicylate simultaneously produces ketosis, stimulation of respiration, and an increase in
Ursodeoxycholic acid (UDCA) therapy in pediatric patients with progressive familial intrahepatic cholestasis (PFIC) Pediatric Hepatology Unit and INSERM U 347, H�pital de Bic�tre, Paris, France
Journal: Hepatology (1995)

Human steroid 5β-reductase (aldo-keto reductase 1D1) catalyzes the stereospecific NADPH-dependent reduction of the C4–C5 double bond of Δ4-ketosteroids to yield an A/B cis-ring junction. This cis-configuration is crucial for bile acid biosynthesis and plays important roles in steroid metabolism. The biochemical properties of the enzyme have not been thoroughly studied and conflicting data have been reported, partially due to the lack of highly homogeneous protein. In the present study, we systematically determined the substrate specificity of homogeneous human recombinant AKR1D1 using C18, C19, C21, and C27 Δ4-ketosteroids and assessed the pH-rate dependence of the enzyme. Our results show that AKR1D1 proficiently reduced all the steroids tested at physiological pH, indicating AKR1D1 is the only enzyme necessary for all the 5β-steroid metabolites present in humans. Substrate inhibition was observed with C18 to C21 steroids provided that the C11 position was unsubstituted. This structure activity relationship can be explained by the existence of a small alternative substrate binding pocket revealed by the AKR1D1 crystal structure. Non-steroidal anti-inflammatory drugs which are potent inhibitors of the related AKR1C enzymes do not inhibit AKR1D1. By contrast chenodeoxycholate and ursodeoxycholate were found to be potent non-competitive inhibitors suggesting that bile-acids may regulate their own synthesis at the level of AKR1D1 inhibition.
Relations between Offending, Injury and Illness
Authors: Jonathan Shepherd, David Farrington, John Potts
Journal: Journal of the Royal Society of Medicine (2002)

The objectives of this study were to determine relations between offending and health, and how illness and injury relate to concurrent offending—whether offending predicts health or vice versa, and whether relations persist after adjustment for childhood predictors of offending. Data collected in the Cambridge Study in Delinquent Development were analysed. This is a prospective longitudinal survey of 411 South London males first recruited at age 8. Information about injuries and illnesses between ages 16 and 18 was set against information on offending and other types of antisocial behaviour. Males who were injured (especially in assaults) tended to be convicted, to be violent, to have unskilled manual jobs and to be generally antisocial. Respiratory tract illnesses were negatively related to convictions and antisocial behaviour in general. Drug users were significantly likely to be ill. Adult convictions were predicted by childhood troublesome behaviour, daring/hyperactivity, low IQ/attainment, a convicted parent, family disruption/poor supervision and poverty. Assault injuries and respiratory tract illnesses did not predict adult convictions independently of these childhood factors. It was concluded that injury is one symptom of an antisocial personality that arises in childhood and persists into adulthood. Therefore, measures that lead to a reduction in offending should also lead to a reduction in concurrent injuries. Negative relations between a range of antisocial behaviours and respiratory tract illness deserve further study.