tbuckley/cabot-search huggingface dataset:
Abstract 5058: The association between smoking status at diagnosis and breast cancer specific mortality in Ireland: A population based study
Authors: Maeve Kiely, Joesph McDevitt, Linda Sharp
Journal: Cancer Research (2019)

Abstract Background: Breast cancer is the most commonly diagnosed cancer worldwide and is a leading cause of breast cancer mortality in females. In recent years, 5 year survival rates have greatly improved for breast cancer however a clear disparity exists between survival in countries of high income compared to low and middle income. Disparity in survival also exists within individual countries. The identification of modifiable lifestyle factors can be an impactful and cost effective way to improve breast cancer outcomes worldwide, particularly in low income counties. An association between active smoking at diagnosis and breast cancer specific mortality has been reported by a number of studies to date. However, there is a paucity of studies undertaken in European populations. This large study was conducted to investigate whether smoking status at diagnosis is an independent prognostic factor for breast cancer specific mortality in the Irish female population. Methods: All data was derived from the National Cancer Registry Ireland database which records all incident cancers in the Republic of Ireland. Completeness of case ascertainment at 5 years after diagnosis is estimated to be at 98%. Multivariable Cox proportional Hazards models were used to compare breast cancer specific mortality in current smokers, ex-smokers and never smokers. Subgroup analyses by breast cancer molecular subtype was also conducted. Results: Data for women with known smoking status at time of diagnosis included 37,711 invasive breast cancer cases that accrued 263,626 women-years. Current smokers had a significantly increased risk of breast cancer specific mortality compared to never smokers (multi-variable HR, 1.3; 95% CI, 1.19, 1.41). Ex-smokers did not have a significantly different hazard ratio compared to never smokers (HR, 1.02; 95% CI, 0.92, 1.12). In subgroup analyses, risk of dying from breast cancer was increased most for current smokers with HER2+ disease compared to never smokers in the 5 years post diagnosis (HR, 1.53; 95% CI, 1.11, 2.12). This was followed by luminal A disease (HR, 1.39: 95% CI, 1.17, 1.65). Conclusion. Breast cancer patients who are current smokers at diagnosis have a statistically significant increased risk of breast cancer specific mortality. This risk differs depending on molecular subtype of disease. Citation Format: Maeve Kiely, Joesph McDevitt, Linda Sharp. The association between smoking status at diagnosis and breast cancer specific mortality in Ireland: A population based study [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 5058.
Angel Dust
Authors: Sidney Cohen
Journal: JAMA (1977)

PHENCYCLIDINE hydrochloride (Sernylan) was investigated during the 1950s as an anesthetic agent. Although it was found to be effective for analgesia and anesthesia, certain side effects, especially postoperative agitation and delirium that lasts for hours, precluded its final acceptance. Later, phencyclidine was discovered to be a satisfactory anesthetic agent for certain animals, and is currently marketed for that purpose. A chemically related compound, ketamine hydrochloride (Ketalar) is employed as a human anesthetic. On the street, phencyclidine is known by some 20 names, including "Angel Dust," "PCP," and "Hog." Angel dust appears in many forms: as a crystalline powder, and as tablets and capsules in a variety of colors, shapes, and sizes. Angel dust is manufactured by kitchen chemists from readily available precursors. The procedure is not complicated and supplies are plentiful. This explains why phencyclidine is a common substitute for less available psychedelic drugs such as mescaline. An occasional batch
A photonumeric scale for the assessment of atrophic facial photodamage
Authors: J. Ayer, A. Ahmed, E. Duncan-Parry, P. Beck, T.W. Griffiths, R.E.B. Watson, C.E.M. Griffiths
Journal: British Journal of Dermatology (2018)

Skin ageing occurs naturally over time. This process can be sped up by factors such as sunlight, otherwise known as photodamage. In fair‐skinned individuals, something called hypertrophic facial photodamage (HP) has been reported, with thick, coarse wrinkling, which looks leathery and feels rough, often with irregular colouring. However, another subgroup of facial photodamage has now been described in which individuals have thin, shiny, glossy, skin with broken blood vessels, minimal wrinkling and an increased chance of developing certain skin cancers. This is termed atrophic photodamage (AP). The purpose of this study, conducted in Manchester in the UK, was to develop a scale to assess and measure severity of AP. This had already been done for HP but there was no such scale for measuring AP. This was done by creating a bank of 393 photographs of people with AP and selecting five representative images of different severities to make up the scale. Each image was assigned a number 0 through 8, where 0 was no photodamage and 8 was severe AP, making a nine‐point scale. The photonumeric scale was tested against a scale where the features of atrophic photodamage were described, rather than shown on pictures (descriptive scale). The study clearly demonstrated that the photonumeric scale was significantly better than the descriptive one in terms of repeatability (i.e. producing the same result with different testers) and reproducibility (producing the same result with the same tester a week later). This scale will be a valuable tool to assess and grade AP for clinical studies, particularly as this group seem to have a higher chance of developing certain types of skin cancer.
Risk of Major Adverse Cardiovascular Events With Inhaled Anticholinergics in Patients With Chronic Obstructive Pulmonary Disease
Authors: Steven Kesten
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A piece of my mind. The rest of him
Authors: L. Morgenstern
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
“No Language but a Cry”
Authors: Joseph Garland
Journal: New England Journal of Medicine (1972)

Alfred, Lord Tennyson, composing "In Memoriam", included a few lines pertinent to the present subject:But what am I? An infant crying in the night: An infant crying for the light: And with no language but a cry.Most physicians engaged to any extent in pediatric practice are aware not only that crying is one of the inalienable privileges of infancy, as the poet implied, but that different cries may have different meanings; crying is a language in itself, based on its genesis, its volume, its pitch, its energy requirements and other characteristics. Even the most experienced pediatrician, however, could . . .
Induction of Contact Dermatitis in Guinea Pigs by Quaternary Ammonium Compounds: The Mechanism of Antigen Formation
Authors: Karin U. Schallreuter, Karl Heinz Schulz, John M. Wood
Journal: Environmental Health Perspectives (1986)

Eight quaternary ammonium compounds were tested for their ability to induce contact dermatitis in guinea pigs by using a modified Freund's complete adjuvant test together with the guinea pig maximization test. Only two quaternary ammonium salts of the eight tested could be designated as strong allergens. These two active substances were shown to be capable of stable association with membrane lipids in forming immunogenic complexes. This surface complexation phenomenon was confirmed by using a spin-labeled quaternary ammonium salt which competed for binding sites at the surface of epidermal cells in vivo. Electron spin resonance was used to demonstrate that stable "ion-pairs" are formed between binding sites and the two allergenic preservatives. Furthermore, information was obtained on the kinetics of immunogenic complex formation as well as on the position and orientation of the quaternary ammonium ion at the cell surface.
THE PASSING OF THE CORONER.
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Highlights
Journal: JAMA Oncology (2015)

The collection of adverse events on clinical trials, in the past, has been based on verbal reports from the patient to the study team.Dueck et al evaluated the validity and reliability of a patient-reported outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE) using a sample of 975 adults undergoing treatment for cancer.The data showed favorable evidence for the use of the tool in evaluating adverse events.These data lay the foundation for the integration of patient-reported adverse events into standard adverse event reporting systems.Movsas provides an Invited Commentary.
THE PHARMACOPEIAL CONVENTION
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Jogging
Authors: Henry D. McIntosh
Journal: JAMA (1979)

CORONARY artery disease has reached epidemic proportions in this country and other affluent industrialized societies because of the prevalence of three definite and two strongly suspected risk factors. The three definite risk factors are cigarette smoking, consumption of a rich, fat-burdened, cholesterol-containing diet, and hypertension. Low-tar, low-nicotine cigarettes do not greatly reduce the risk of coronary artery disease, although they may reduce the risk of lung cancer. Coronary atherosclerosis is thought to be accelerated by the carbon monoxide in cigarettes, and this is not reduced in the filtered and low-tar, low-nicotine products. The two strongly suspected risk factors are obesity and sedentary living. Many cardiologists believe that the uncertainties as to the importance of exercise, or lack thereof, and obesity are due to the difficulty of measuring, in a scientifically acceptable study, the importance of these factors' contributing to coronary artery disease without including concomitant changes in the blood pressure
Undergraduate medical education
Authors: H. S. Jonas
Journal: JAMA (1989)

<h3>INTRODUCTION</h3> The decade of the 1980s continues to be marked by significant societal changes that have an impact on American medical education. Foremost among the trends has been the declining number of applicants to US medical schools. Undergraduate medical education faces enormous challenges as the pressures for accountability by the profession mount. Not only must medical educators respond to the rapidly expanding knowledge base in the biomedical sciences, but they must balance that with the charge of training physicians who will spend more time with their patients and demonstrate compassion and caring. New methods of health care delivery, shorter hospital stays, and the ascendancy of the ambulatory care setting have all created a need for reexamination of the methodology and the settings that can best be employed for teaching medical students. Challenges such as the acquired immunodeficiency syndrome epidemic, the continued pressures of professional liability, and demands for better supervision
The role of vascular dynamics in the development of atherosclerosis
Authors: M. Texon
Journal: JAMA (1965)

This report identifies the inception and progressive pathology of atherosclerosis resulting from the effects of hydraulic forces inherent in the circulatory system.<sup>1</sup>Vascular dynamics relates the effect of hydraulic forces to the biological response of blood vessels. The forces and principles involved are directly comparable to those which prevail in all hydraulic systems with due regard to local conditions of flow and hydraulic characteristics.<sup>2</sup>The laws of fluid mechanics are fully applicable to the hydrobiological conditions found in the human circulatory system, and the composite effects of their operation are both prerequisite and conducive to atherosclerosis. Previous reports<sup>3,4</sup>have correlated atherosclerotic lesions found at autopsy with their localization in the circulatory system as determined by hydraulic forces. Rigid and flexible model hydraulic systems built to simulate the specifications of human blood vessels with respect to pulsatile flow, volumetric flow, velocity of flow, and anatomical geometry confirm the
Corrigendum
Journal: BMJ (1942)

SUPPLE vwNT To THE able.One should deal with the legal aspect from the medical point of view, and the other with the.business side.The matter of the expense of these experts should not be considered, as the status and pockets of the medical profession are in jeopardy.The attitude of the permanent officials of the Ministry may not be over-sympathetic towards the profession in view of the troubles they have had with the "doctors" in the past.In this connexion it may be recalled that the "doctors " were defeated.I am aware that this suggestion has been made before, but I wish to emphasize its vital importance and urgent necessity.-Iam, etc.,
Social Medicine and Medical Economics
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
EIGHTY-FIRST ANNUAL MEETING OF THE British Medical Association
Journal: BMJ (1913)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following EIGHTY-FIRST ANNUAL MEETING OF THE British Medical Association Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Early-Childhood Membranous Nephropathy Due to Cationic Bovine Serum Albumin
Authors: Hanna Debiec, Florence Lefeu, Markus J. Kemper, Patrick Niaudet, Georges Deschênes, Giuseppe Remuzzi, Tim Ulinski, Pierre Ronco
Journal: New England Journal of Medicine (2011)

The M-type phospholipase A(2) receptor (PLA(2)R) was recently identified as a candidate antigen in 70% of cases of idiopathic membranous nephropathy, a common form of the nephrotic syndrome. The nature of antigens involved in other idiopathic and secondary membranous nephropathies remains unclear.We searched for antibodies against bovine serum albumin and circulating bovine serum albumin by means of enzyme-linked immunosorbent assay and Western blotting in serum specimens obtained from 50 patients with membranous nephropathy and 172 controls. The properties of immunopurified circulating bovine serum albumin obtained from serum specimens were analyzed with the use of two-dimensional sodium dodecyl sulfate-polyacrylamide-gel electrophoresis. We detected bovine serum albumin in glomerular deposits and analyzed the reactivity of eluted IgG.Eleven patients, including four children, had high levels of circulating anti-bovine serum albumin antibodies, of both the IgG1 and IgG4 subclasses. These patients also had elevated levels of circulating bovine serum albumin, without an increase in circulating immune complex levels. Bovine serum albumin immunopurified from the serum specimens of these four children migrated in the basic range of pH, whereas the bovine serum albumin from adult patients migrated in neutral regions as native bovine serum albumin. Bovine serum albumin was detected in subepithelial immune deposits only in the children with both high levels of cationic circulating bovine serum albumin and bovine serum albumin-specific antibodies, and it colocalized with IgG in the absence of PLA(2)R. IgG eluted from such deposits was specific for bovine serum albumin.Some patients with childhood membranous nephropathy have both circulating cationic bovine serum albumin and anti-bovine serum albumin antibodies. Bovine serum albumin is present in immune deposits, suggesting that cationic bovine serum albumin is pathogenic through binding to the anionic glomerular capillary wall and in situ formation of immune complexes, as shown in experimental models.
Book Review L'Examen du Malade . By P. Delmas, G. Giraud, E. Jeanbrau, E. Leenhardt, J. Margarot, P. Pages, V. Riche, L. Rimbaud, J. Terracol and H. Villard, professors of the Faculty of Medicine of Montpellier. 12°, paper, 365 pp. Paris: Masson et Cie, 1939. 45 Fr. fr.
Journal: New England Journal of Medicine (1940)
Manpower needs by specialty
Authors: H. R. Mason
Journal: JAMA (1972)

When the project reported herein was initiated early in 1971, an increasing number of writers on the subject of medical manpower were calling attention to the problem of physician distribution, both geographic and by specialty. Previously the most-often-repeated problem of the medical service bottleneck had been "an immediate need for 50,000 doctors." However, recent writers have begun to cast doubt on such a shortage, and have suggested that the problem is one of distribution rather than sheer shortage. A few have said that if 50,000 physicians were added to the pool today, the shortages would still appear in the same places, the inner city neighborhoods and the rural towns. My own observations lend credence to these statements, and there is increasing evidence that physicians will continue to shun practice in these locales, placing high value on the geographic attributes of a practice setting. A national study of 16 statesponsored forgiveness