tbuckley/cabot-search huggingface dataset:
Phoenix House. Criminal activity of dropouts
Authors: G. De Leon
Journal: JAMA (1972)

Percentage of arrests was determined for a sample of 254 addicts who did not complete the Phoenix House Program (dropouts) and 104 who were in the last stages of the program. Results showed that the longer the residence the larger the postprogram reduction, eg, dropouts after 12 months' residence showed a 70% change in arrests in one year of followup. It was concluded that addicts with any residential experience in Phoenix, even those who failed to complete the program, showed sharp reductions in criminal activity during and after leaving the program. These changes relate to rehabilitative aspects of the program.
SOUTHERN FEVERS.
Authors: WILLIAM KRAUSS
Journal: JAMA (1903)

In assigning this subject to me, our secretary said he wanted to show that some missionary work on the subject of fevers in the Mississippi Valley was being done, despite the controversies one sees about slow, continued, typho-malarial, and other fevers. With this idea of the scope of the paper, fevers of sepsis, tuberculosis, rheumatism, syphilis, etc., have not been given a place. The cases presented are to be looked on as types of a number of cases seen by the author, and are believed to serve the purpose better than an elaborate discussion for which we have no time. None of the histories are complete, but enough is offered to make the point intended. <h3>1, ACUTE ESTIVAL FEVERS; 2, CASES WITH AUTOPSIES.</h3> Case1.—W. B., male, white, aged 54, was brought to Joseph's Hospital in July, 1900, in an unconscious condition. From others it was learned that he was
ITALY
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A multinational phase II study of PEP02 (liposome irinotecan) for patients with gemcitabine-refractory metastatic pancreatic cancer.
Authors: A. H. Ko, M. A. Tempero, Y. Shan, W. Su, Y. Lin, E. Dito, A. Ong, Y. Wang, G. Yeh, L. Chen
Journal: Journal of Clinical Oncology (2011)

4069 Background: PEP02 is a novel nanoparticle liposome formulation of irinotecan (CPT-11) that has improved pharmacokinetics and tumor biodistribution of both CPT-11 and its active metabolite-SN38 compared to the free form drug. PEP02 has showed encouraging safety and efficacy in various tumor types, including significant antitumor activity in a human pancreatic cancer L3.6pl orthotopic nude mouse xenograft model. In previous phase I studies, PEP02 either alone or in combination with 5-FU/LV demonstrated prolonged disease control in 5 of 7 (71%) patients (pts) with gemcitabine (GEM)-refractory advanced pancreatic cancer (PC). This phase II study aims to evaluate PEP02 monotherapy as second-line treatment in pts with metastatic, GEM-refractory PC. Methods: Pts were eligible if they had metastatic pancreatic adenocarcinoma, KPS ≥ 70, and progressed following one line of GEM-based therapy. Treatment consisted of PEP02 120 mg/m2 administered as a 90-minute infusion every 3 weeks. A Simon’s 2-stage design was used with 16 pts in the first stage and 39 pts in total; primary objective was 3-month survival rate (OS3-month). Results: Between March 2009 and September 2010, 41 pts were enrolled at 3 centers in the U.S. and Taiwan. Characteristics for the 40 ITT pts: 19 M/21 F; age 39-82 yrs; 25 Asian/15 Caucasian, KPS 100/90/80/70: 7/16/7/10. Mean number of treatment cycles is 5.25 (range, 1-26). Objective response rate is 5% and disease control rate (minor response + stable disease > 2 cycles) is 50%. 10 (30.3%) of 33 pts with elevated baseline CA19-9 have had > 50% biomarker decline. The OS3-month is 75%, with median progression free survival (PFS) and OS of 9 and 21.6 weeks, respectively. There was no correlation between duration of prior GEM-based therapy and survival after PEP02 treatment. The most common G3/4 adverse events are: leucopenia/neutropenia, anemia, diarrhea, and fatigue. Conclusions: This study has already met its primary endpoint (predicted OS3-month ≥ 65%). PEP02 appears to have both activity and tolerable side effects for pts with metastatic, GEM-refractory PC, and represents a promising option for this pt population with few options.
Methemoglobinemia associated with well water
Authors: L. W. Miller
Journal: JAMA (1971)

A case of infant methemoglobinemia associated with milk formula prepared from well water containing excess nitrates occurred in Texas. The existence of numerous rural wells with high nitrate concentrations has been documented in various areas through the United States in the past and again in Texas in 1969. These private wells and certain rural municipal water supplies represent a possible source for cases of methemoglobinemia.
Present Status of Hepatic Function Tests in Detection of Carriers of Viral Hepatitis
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
If youngsters overdose with anabolic steroids, what's the cost anatomically and otherwise?
Authors: V. S. Cowart
Journal: JAMA (1989)

A COMMON THEME expressed by several panelists at the recent National Institute on Drug Abuse meeting on anabolic steroids, in Rockville, Md, is that youngsters who use steroids almost invariably take a larger dose than they need to obtain the desired physical effects. <h3>An Effect on Height?</h3> Because steroids can cause premature closure of the epiphysis, there is concern that some young users will end up shorter than they would have been, investigators say. Whether they are more vulnerable to long-term damage caused by taking sex hormones is another area for research. Allen Rogol, MD, a pediatric endocrinologist at the University of Virginia, Charlottesville, says it appears that testosterone works—at least in part— through growth hormone in adolescent boys and that it promotes an increase in the secretion of growth hormone. He studied a group of boys with constitutional delay of growth who received testosterone and noted that the amount
Research and Medical Progress and Other Addresses.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fibrinolysin and Related Esterases in Patients with Cirrhosis
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Incorrect Quotation.
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Studies of Pulmonary Function
Authors: B. G. Ferris
Journal: New England Journal of Medicine (1960)

Ventilatory TestsA variety of tests have been devised to measure the volume of gas that can be moved into or out of the lungs. The maximum breathing capacity (MBC), also called the maximum voluntary ventilation (MVV), is one of these. This test, however, is becoming less popular because the motivation or co-operation of the patient and his capacity to do the muscular work are extremely important factors.37 To replace the MBC, single-breath tests have been devised. In these a maximal inspiration followed by a rapidly expelled or forced vital capacity is required.‡In Great Britain three technics are used. . . .
Echocardiogram
Authors: Judith Skillman
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BOOK REVIEW
Authors: M. POSNER
Journal: JNCI Journal of the National Cancer Institute (1995)

BOOK REVIEW Get access Atlas of Surgical Oncology John H. Donohue Jon A. van Heerden John R. T. Monson eds. Cambridge, Mass. : Blackwell Scientific Publications, Inc. , 1995 , 324 pp., illus. $125. ISBN 0-86542-422-5 MITCHELL POSNER, M.D. MITCHELL POSNER, M.D. 2471 5th Ave. Suite 300 Pittsburgh, PA 15213 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 87, Issue 13, 5 July 1995, Pages 1018–1019, https://doi.org/10.1093/jnci/87.13.1018 Published: 05 July 1995
02.41 New autoantigen (jktbp) part of stress granules closes the sensitivity gap in rheumatoid arthritis
Authors: Bianka Marklein, Madeleine Jenning, Karen Münzner, Zoltan Konthur, Thomas Häupl, Andrew Cope, Mark Shlomchik, Hans-J Anders, Günter Steiner, Gerd R Burmester, Karl Skriner
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Rheumatoid arthritis triggers the formation of prion-like stress granules. To investigate which members of the heterogeneous nuclear ribonucleoprotein (hnRNP)-family, components of functionally important subcellular particles are targeted by autoantibodies from RA and other systemic rheumatic diseases. <h3>Methods</h3> Using a protein macroarray we identified JKTBP in humans and animal models of inflammatory rheumatic diseases. Bacterially expressed recombinant JKDBP proteins were used to confirm the obtained data. Epitope, TLR7/9 and MyD88 dependency was determined by ELISA. JKTBP expression in cultivated cells and synovial tissue was analysed by indirect immunofluorescence, immunoblot and immunohistochemistry. <h3>Results</h3> Anti-JKTBP autoantibodies were detected in 46% of the patients with systemic lupus erythematosus (n=103), in 20%–30% of the patients with rheumatoid arthritis (n=286), in 10% of the patients with mixed connective tissue disease (n=20) or spondyloathropathy (n=20), and in &lt;10% of patients with other autoimmune disorders (n=382). Sera positive to JKTBP as well as hnRNP-B1, revealed nearly two thirds of the RF IgM/CCP2-seronegative patients as early RA patients. Combining sensitivities to all autoantigens tested (JKTBP, AUF1, hnRNP-B1), it was possible to identify 92% of the early RA patients (n=91). In the MRL/lpr mouse model of SLE, mice deficient of MyD88 or TLR7/9 lacked anti-JKTBP autoantibodies, whereas mice deficient of SIGIRR/TIR8 showed enhanced anti-JKTBP autoantibody production. These results show that autoantibody generation against JKTBP, AUF1, hnRNP-B1 is dependent on TLR7 and TLR9 like rheumatoid factor different to TLR7 dependent generation of snRNPs. For all tested autoantigens either their titter or generation are dependent on the activation of innate immunity genes MyD88 and SIGIRR/TIR8 gene. In localization, experiments anti-JKTBP autoantibodies specifically stained stress granules (SG) in the cytoplasm. Immunohistochemical studies revealed JKTBP to be highly expressed in SG in the cytoplasm of RA synovial tissue different from OA and normal control tissue. <h3>Conclusion</h3> These data identify SG as targeted particle in RA and JKTBP as a novel autoantigen in RA, SLE patients and mouse models of inflammatory rheumatic diseases. In combination with the hnRNPs AUF1 and hnRNP-B1, JKTBP autoantibodies close the sensitivity gap in RA left by rheumatoid factor and anti-CCP2 antibodies.
The Complete Medical Pocket-Formulary and Physician's Vade-Mecum: Containing Upwards of 2,500 Prescriptions, Collected from the Practice of Physicians and Surgeons of Experience, American and Foreign. Arranged for Ready Reference Under an Alphabetical List of Diseases. Also a Special list of New Drugs, with Their Dosage, Solubilities and Therapeutic Applications; Together with a Table of Formulæ for Suppositories; a Table of Formulæ for Hypodermic Medication; a List of Drugs for Inhalation; a …
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Table of Contents
Authors: Stavroula Paschou, Nikolaos Spyrou, Christos Mantzoros, Mahtab Sharifi, Małgorzata Walus-Miarka, Barbara Idzior-Waluś, Maciej Malecki, Marek Sanak, Ros Whittall, Ka Li, Marta Futema, Steve Humphries, Hye Yoo, Hwan Yong, Soon Hwang, Jae Eo, Ho Hong, Ji Seo, Sin Kim, Nan Kim, Seop Dong, Hyun Choi, Kyung Baik, Charlotte Vaurs, Jean-Frederic Brun, Monelle Bertrand, Rémy Burcelin, Mael Chalret, Du Rieu, Yves Anduze, Hélène Hanaire, Patrick Ritz, Michael Bancks, Suzette Bielinski, Paul Decker, Naomi Hanson, Nicholas Larson, Hugues Sicotte, Christina Wassel, James Pankow
Journal: Metabolism (2016)
Infection after splenectomy
Authors: R. Platt
Journal: JAMA (1982)

Postsplenectomy infection has engaged the attention of physicians at least since 1919.<sup>1</sup>Publications on the role of the spleen or the sequelae of its absence continue to appear almost weekly. After decades of interest, what do we know about the risk of infection after splenectomy? We seem to know that young children experience a high attack rate, particularly of fulminant infections caused by encapsulated organisms. We have suspected the same thing about adults, although the evidence for this conclusion has been much less secure. There has been general but not universal agreement that adults have a higher-than-normal risk of infection after splenectomy, and also that the magnitude of this risk varies with the reason for splenectomy. However, the measured or inferred risk estimates cover a very wide range.<sup>2-4</sup>Schwartz and colleagues have provided several useful observations in their article, which appears in this issue (p 2279). The risk
Evidence-Based Medicine: A New Paradigm for the Patient
Authors: LaVera Crawley
Journal: JAMA (1993)

<h3>To the Editor.</h3> —I am responding to the Evidence-Based Medicine Working Group's imprecise use of the term<i>paradigm shift</i>in what otherwise was an informative article.<sup>1</sup>The authors stated that the old paradigm is represented by assumptions guiding clinical practice based on either empirical observations, rationalistic confirmation, Oslerian acumen, and common sense, or a combination thereof. In the purported new paradigm, these assumptions are grounded in the critical appraisal and correct interpretation of medical literature that can then provide the basis of underlying evidence to support and guide clinical decisions. How does the reconciliation of the age-old empiricist-rationalist debate through a systematic analysis of clinical literature represent a paradigm shift in the true Kuhnian sense? Rather than constituting a revolution, it would seem that evidence-based medicine is an example of further developing and professionalizing the prevailing paradigm through a "refinement of concepts that increasingly lessens their resemblance to their
Fulminant Plasmodium falciparum infection treated with exchange blood transfusion
Authors: S. L. Kramer
Journal: JAMA (1983)

A 48-year-old physician, who was not undergoing malaria chemoprophylaxis, contracted<i>Plasmodium falciparum</i>while working in eastern Thailand. In the hospital, he had a peak parasitemia of 72% RBCs infected, associated with CNS dysfunction. As an adjunct to chemotherapy, a double-volume whole-blood exchange transfusion was performed on the first hospital day, dropping the parasitemia to less than 1% within 32 hours. The patient's clinical condition improved, with a prompt reversal of CNS, hepatic, and renal complications. These results, combined with those in previously reported cases, suggest that exchange transfusion should be considered more generally as a life-saving procedure in<i>P falciparum</i>infections. (<i>JAMA</i>1983;249:244-245)