tbuckley/cabot-search huggingface dataset:
SAT0010 Thoracic high resolution computed tomography in patients with ankylosing spondylitis and without respiratory symptoms
Authors: A El Maghraoui, S Chaouir, F Tabache, A Bezza, D Ghafir, V Ohayon, MI Archane
Journal: Annals of the Rheumatic Diseases (2001)

<h3>Background</h3> <h3>Objectives</h3> To identify the spectrum of abnormalities seen on thoracic High Resolution Computed Tomography (HRCT) in patients with ankylosing spondylitis (AS), and to look for correlations with clinical findings, plain radiography and pulmonary function testing. <h3>Methods</h3> 28 patients with AS meeting the modified New York criteria and without history of respiratory symptoms were enrolled prospectively: 25 men (89.2%) and 3 women with mean age of 37.8 (9.1) years [17–66] and mean disease duration of 7.8 (4.6) years [0.4–19]. All patients underwent posteroanterior plain chest radiography, HRCT and pulmonary function tests. <h3>Results</h3> HRCT revealed abnormalities in 17 patients (60.7%): these included interstitial lung disease (n = 2), paraseptal emphysema (n = 2), apical fibrosis (n = 2), bronchiectasis (n = 1), and non-specific interstitial lung disease (n = 11). Plain radiography was abnormal in only 2 cases. Comparison between patients with and without defined thoracic HRCT abnormalities showed no differences in age, sex, disease duration, history of smoking, radiological scores (syndesmophytes score, BASRI) or ESR but showed significant statistical difference in symptomatic severity parameters (Schöber, BASMI, BASDAI). Pulmonary function tests showed a restrictive process in four patients in whom three had an abnormal chest HRCT and an obstructive process in two patients in whom one had emphysema and apical fibrosis on chest HRCT. <h3>Conclusion</h3> This study, which describes thoracic HRCT findings in patients with AS and without respiratory symptoms, confirms the high prevalence of a spectrum of abnormalities undetectable on standard plain radiography.
Adjunct hospital emergency toxicology service. A model for a metropolitan area
Authors: J. P. Horwitz
Journal: JAMA (1976)

A feasibility demonstration with a gas chromatograph/mass spectrometer/computer system (GC/MS) was initiated to provide a 24-hour (seven days/week) adjunct emergency toxicology service to the hospitals in the tricounty area comprising Metropolitan Detroit. During June 1, 1974, to April 1, 1975, more than 85 different drugs and other agents were identified in the body fluids of approximately 1,000 victims of accidental or deliberate poisonings. At least one toxic substance was identified in 57% of the cases, and the presence of two or more drugs was established in one of five (19%) of the victims. This study indicates that a centrally located GC/MS/computer system can provide an effective adjunct emergency toxicology service for an entire metropolitan community and thereby provide guidelines for a prompt and rational therapy. (<i>JAMA</i>235:1708-1712, 1976)
Chart reminders in the diagnosis of anemia
Authors: R. S. Wigton
Journal: JAMA (1981)

We hypothesized that chart reminders would decrease the number of cases in which a low admission hemoglobin level was missed or ignored. Additionally, we compared the cost of generating the chart reminders by hand with the estimated cost of modifying the university hospital information system for this function. For three months, two medical students reviewed all abnormal hemoglobin results and assigned those more than 1 g below normal limits to a control or study group. A questionnaire, placed in all study group charts, requested an explanation for the low hemoglobin level. Eleven of 141 study cases and 16 of 150 control cases failed the audit criteria (differences not significant). The cost was $308 compared with $3,000 for altering the hospital information system. We conclude that chart reminders did not improve the detection of anemia and that it cost less to test this intervention by manually simulating the computer function. (<i>JAMA</i>1981;245:1745-1747)
SITUS INVERSUS
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
<i>QuickStats:</i>Age-Adjusted Prevalence*<sup>,</sup>† of Adults Aged ≥18 Years with Hypertension§ Who Are Aware They Have Hypertension,¶ by Sex and Race/Ethnicity — National Health and Nutrition Examination Survey, United States, 2011–2014
Journal: MMWR Morbidity and Mortality Weekly Report (2016)

For the period 2011-2014, 83.3% of adults aged ≥18 years with hypertension were aware of their hypertension status. Overall, a smaller percentage of non-Hispanic Asian adults (74.0%) with hypertension were aware of their status compared with non-Hispanic white (83.9%), non-Hispanic black (85.9%), and Hispanic adults (80.5%) with hypertension. This pattern generally was found for both men and women, with the exception of non-Hispanic Asian men and Hispanic men, where the difference was not significant. A larger percentage of non-Hispanic black and Hispanic women were aware of their hypertension condition compared with non-Hispanic black and Hispanic men, respectively.
LAW AND MEDICINE
Authors: Richard P. Bergen
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Erratum
Authors: BERNARD LOWN
Journal: Circulation (1974)

Dr. L. S. Gettes has alerted me of the fact that three figures appearing in our review article devoted to the subject of ventricular tachycardia (Circulation 47: 1364, 1973) appear to be adaptations of figures which he had published earlier (Am J Cardiol 28: 526, 1971). These figures (in our article Nos. 1, 7 and 8) were diagramatic simplifications of certain electrophysiologic concepts. One might rationalize that these figures were based on what is now a commonly held viewpoint and furthermore, that they do not represent anyone's painfully acquired data. Of course, such attempts at justification are mere frivolous sophistry. It is best to hasten and apologize to Dr. Gettes for inexcusable oversights which were exclusively my fault. If there is any comfort to be gained from this transgression, perhaps it resides in the realization that next to promulgation of truth, there is some virtue in the public recantation of error.
Study design
Authors: P. Sedgwick
Journal: BMJ (2009)

Researchers used a randomised, crossover, single blind, controlled trial to investigate whether local warming of the lower arm and hand facilitated peripheral venous cannulation for patients with leukaemia who required chemotherapy.1 The hand and lower forearm of participants was covered with a carbon fibre heating mitt for 10 minutes. Local warming (mitt warmed to 52°C) was compared with passive insulation (mitt used but heater not switched on). A nurse anaesthetist then inserted a cannula and recorded whether insertion was a success, plus the time taken. Each patient attended two visits at least one week apart. Which of the following statements, if any, are true?
CELL PLACE AND POWER.
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Voices With a Message
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Health Systems
Authors: Renate Wilson
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
XELOX (capecitabine and oxaliplatin) as 1st line treatment for elderly patients (pts) with advanced/metastatic colorectal cancer (MCRC)
Authors: L. López-Gómez, P. Escudero, A. Yubero, J. Feliú, A. Salud, A. Galán, M. Bolaños, J. M. Vicent, F. Losa, M. González-Barón
Journal: Journal of Clinical Oncology (2004)

3688 Background: XELOX is a highly active combination in 1st line MCRC, comparable to FOLFOX with little neutropenia and a convenient 3-weekly cycle length. As a well-tolerated, more home-based therapy, XELOX merits investigation in a more elderly pt population. Methods: Objectives of this phase II study were response rate (RR), safety profile, time to progression, overall survival and clinical benefit after XELOX chemotherapy as 1st line treatment in pts aged ≥ 70 years with histologically proven MCRC. Selection criteria included no prior chemotherapy (except adjuvant therapy), measurable disease according to RECIST, ECOG PS ≤ 2 and adequate bone marrow, renal and hepatic function. Patients received oxaliplatin 130mg/m2 i.v. D1 followed by oral capecitabine 1000 mg/m2 twice daily for 14 days (750 mg/m2 if Cr Cl=30–50 ml/min) every 3 weeks. Toxicity was evaluated every cycle using WHO toxicity criteria. Results: 32 pts are evaluated for safety to date: M/F, 23/7, median age 75 years (70–82), ECOG PS 0/1: 47%/53%. 96% pts had no comorbidity, 92% had mild dependence on help (Barthel Index) and most (M/F 77%/43%) were autonomous (Lawton Index). Tumor sites were colon (n=21) and rectum (n=10). Median number of metastatic sites was 1 (1 site 86%, ≥ 2 sites 14%), in liver (79%), lung (25%) and nodes (11%). Previous treatment included surgery (87%), chemotherapy (32%) and radiotherapy (10%). Currently a total of 95 cycles have been administered: median 3 (1–8). Median relative dose intensity is 95% for oxaliplatin and 97% / 91% (Cr Cl ≤50 / Cr Cl >50 ml/min, respectively) for capecitabine. There was 1 treatment-related death: G4 diarrhea. Efficacy data will be presented. Conclusions: XELOX appears well tolerated in 1st line treatment of elderly pts with MCRC. No significant financial relationships to disclose.
Issue Highlights
Journal: Circulation (2007)

In this study, 845 individuals (age 62Ϯ11 years), including 106 patients without coronary artery disease (CAD) and 739 patients with chronic stable CAD, underwent a total of 1053 quantitative, coronary pressurederived collateral measurements between March 1996 and April 2006.All of the patients were prospectively included in a collateral flow index (CFI) database that contained information on recruitable collateral flow parameters obtained during a 1-minute coronary balloon occlusion, and they were divided into 2 groups: those with CFI Ͻ0.25 and those with CFI Ն0.25.Cumulative 10-year survival rates in relation to all-cause deaths and cardiac deaths were 71% and 88% in patients with low CFI, respectively, and 89% and 97% in the group with high CFI (Pϭ0.0395 and Pϭ0.0109).These results indicate a correlation between a CFI Ͼ0.25 and a reduced rate of cardiac deaths and acute myocardial infarction in patients with chronic stable CAD.See p 975.
American Resorts; with Notes upon their Climate.
Journal: JAMA (1889)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Software
Authors: Yan Chow
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Climate Variation and Incidence of Ross River Virus in Cairns, Australia: A Time-Series Analysis
Authors: Shilu Tong, Wenbiao Hu
Journal: Environmental Health Perspectives (2001)

In this study we assessed the impact of climate variability on the Ross River virus (RRv) transmission and validated an epidemic-forecasting model in Cairns, Australia. Data on the RRv cases recorded between 1985 and 1996 were obtained from the Queensland Department of Health. Climate and population data were supplied by the Australian Bureau of Meteorology and the Australian Bureau of Statistics, respectively. The cross-correlation function (CCF) showed that maximum temperature in the current month and rainfall and relative humidity at a lag of 2 months were positively and significantly associated with the monthly incidence of RRv, whereas relative humidity at a lag of 5 months was inversely associated with the RRv transmission. We developed autoregressive integrated moving average (ARIMA) models on the data collected between 1985 to 1994, and then validated the models using the data collected between 1995 and 1996. The results show that the relative humidity at a lag of 5 months (p < 0.001) and the rainfall at a lag of 2 months (p < 0.05) appeared to play significant roles in the transmission of RRv disease in Cairns. Furthermore, the regressive forecast curves were consistent with the pattern of actual values.
Autoantibodies to BCOADC-E2 in patients with primary biliary cirrhosis recognize a conformational epitope
Authors: Patrick S. C. Leung, David T. Chuang, Max R. Wynn, Sanghoon Cha, Dean J. Danner, Aftab Ansari, Ross L. Coppel, Eric M. Gershwin
Journal: Hepatology (1995)

Primary biliary cirrhosis (PBC) is an autoimmune disease of liver associated with a unique serologic response to mitochondrial autoantigens. Many of the autoantigens recognized by autoantibodies in PBC are members of the 2-oxo-acid dehydrogenase complex. The two major autoantigens are the E2 component of the pyruvate dehydrogenase complex (PDC-E2) and the E2 component of the branched chain 2-oxo-acid dehydrogenase complex (BCOADC-E2). The autoantibody response to PDC-E2 has been mapped to one immunodominant epitope, which consists of both linear and conformational components. The presence of a single immunodominant epitope in PDC-E2 is unusual when contrasted to the immune response to autoantigens in other human autoimmune diseases. We have mapped the epitope recognized by antimitochondrial autoantibodies (AMA) specific to BCOADC-E2 in patients with PBC by taking advantage of the full-length bovine BCOADC-E2 complementary DNA (cDNA) and a series of expression clones spanning the entire molecule. Reactivity to the various expression clones was studied by immunoblotting, enzyme-linked immunosorbent assay (ELISA), as well as selective absorption of patient sera by expressed protein fragments. Autoantibodies to BCOADC-E2 map within peptides spanning amino acid residues 1 to 227 of the mature protein; our data demonstrate that the epitope is dependent on conformation and includes the lipoic acid binding region. However, only the full-length clone (amino acid residue 1 to 421) is sufficient to remove all detectable BCOADC-E2 reactivity. Moreover, the absence of lipoic acid on the recombinant polypeptides used in this study indicates that antibody binding to BCOADC-E2 is not dependent on the presence of lipoic acid. (Hepatology 1995; 22:505-513.)
Detection and Characterization of DNA Adducts at the Femtomole Level by Desorption Ionization Mass Spectrometry
Authors: Jackson O. Lay, M. Paul Chiarelli, Matthew S. Bryant, Randall W. Nelson
Journal: Environmental Health Perspectives (1993)

Current methodologies for the detection and isolation of carcinogen-DNA adducts have advanced beyond the capabilities of the methods used to elucidate their structures. This difficulty seriously limits the potential use of DNA-carcinogen adducts in human dosimetry. We have investigated two general strategies for the analysis of model arylamine-nucleoside adducts using desorption ionization mass spectrometry (MS). Using fast atom bombardment MS-MS with constant neutral loss scans, we can identify the protonated molecule of derivatized adducts in samples as small as 1 pmole, and then apply daughter ion MS-MS scans to obtain structure-specific fragmentation. Using this strategy we have differentiated adducts having the same carcinogen and different bases [e.g., N-(deoxyadenosin-8-yl)-4-aminobiphenyl and N-(deoxyguanosin-8-yl)-4- aminobiphenyl] or the same base and different carcinogens [e.g., N-(deoxyguanosin-8-yl)-4- aminobiphenyl and N-(deoxyguanosin-8-yl)-2-aminofluorene]. In the second approach we used laser desorption time-of-flight MS to obtain spectra from adduct samples as small as 20 fmole. These data indicate that MS can be used for the analysis of very low (picomole-femtomole) levels of nucleoside adducts, including isomers, and that desorption ionization MS and MS-MS have significant potential for applications in human dosimetry.