tbuckley/cabot-search huggingface dataset:
Quality medical care. A definition
Authors: G. E. Steffen
Journal: JAMA (1988)

This article offers a definition of<i>quality</i>medical care. Quality itself is defined not as consisting of the properties of an object but rather as the capacity of these properties to achieve goals. Accordingly, quality medical care is the capacity of the elements of that care to achieve legitimate medical and nonmedical goals. This definition is compared with other current definitions. I offer answers to the questions of how to choose goals, who chooses goals, and what are legitimate goals. Implications of this definition are discussed, particularly with reference to chart review. Because patient values shape goals and because these values are not always assessed and recorded, it is recommended that a formal assessment of patient values become part of the patient's record. (<i>JAMA</i>1988;260:56-61)
Large brachial artery diameter is associated with angiographic CAD in women: A report from the NHLBI Women's ischemia syndrome evaluation (WISE) Richard Holubkov, Richard H. Karas, Carl J. Pepine, Cheryl R. Rickens, Nathaniel Reichek, William J. Rogers, Barry L. Sharaf, George Sopko, C. Noel Bairey Merz, Sheryl F. Kelsey, Susan P. McGorray, Steven E. Reis. Cardiovascular Institute, University of Pittsburgh, Pittsburgh, PA
Journal: Journal of the American College of Cardiology (2001)
Clinical Hypertension
Authors: Robert H. Moser
Journal: JAMA (1974)

Upward of 23 million Americans, we are told, have blood pressures greater than 160/95 mm Hg and half of these are unaware of their condition. Of those who claim to be aware, only about half are receiving any form of therapy; and half of this half still have blood pressures high enough to be classified as hypertensive. This situation has provoked an unprecedented surge of interest in the epidemiology and management of this epidemic disease. Thus, it was a delight to encounter Norman Kaplan's new book, which tells the working practitioner all he needs to know about hypertension. The text is studded with eye-catching nuggets of information in boxes, clear graphs and charts, and lucid, well-placed illustrations. Most impressive are the relaxed syntax, wellconceived organization, and remarkable comprehensiveness. The contemporary wisdom of pathophysiology, diagnosis, and management (with stress on essential hypertension) occupy almost half the book. With current emphasis on
Erratum: Local increase in thymic stomal lymphopoietin induces systemic alterations in B cell development
Authors: Alexander Astrakhan, Miyuki Omori, Thuc Nguyen, Shirly Becker-Herman, Masanori Iseki, Theingi Aye, Kelly Hudkins, James Dooley, Andrew Farr, Charles E Alpers, Steven F Ziegler, David J Rawlings
Journal: Nature Immunology (2007)
Abstract 93: A Gain-of-Function Mutation in Cardiac Myosin Binding Protein-C Increases Viscoelastic Load and Slows Shortening Velocity in Myocytes from Transgenic Mice
Authors: Kristina L Bezold, Jaskiran K Khosa, Samantha P Harris
Journal: Circulation Research (2014)

Cardiac myosin binding protein C (cMyBP-C) is a sarcomeric protein involved in the regulation of cardiac muscle contraction. Effects of cMyBP-C on contraction are thought to be mediated in part by limiting the interactions of actin and myosin to slow myocyte shortening velocity and power output. Although interactions with myosin S2 on the thick filament have been proposed as a way in which cMyBP-C could limit shortening velocity (e.g., by creating a drag force on myosin heads), interactions of cMyBP-C with actin could also account for slowed shortening velocity. For instance, cMyBP-C could create a drag that opposes filament sliding by transiently linking thick and thin filaments together. To explore this possibility we created transgenic mice that express a mutant cMyBP-C with a point mutation, L348P (human L352P), located in a conserved sequence within the regulatory M-domain that increases cMyBP-C binding to actin in vitro. We reasoned that if the mutation also enhanced binding to actin in sarcomeres then shortening velocity would be slowed in myocytes from L348P mice. Results show that transgenic mice expressing the L348P mutation are viable and that L348P cMyBP-C is expressed in sarcomeres. Permeabilized myocytes from transgenic mice showed altered force production including reduced maximal force and enhanced calcium sensitivity of tension. Shortening velocity and power output were significantly reduced whereas passive stiffness and myocyte visco-elasticity were significantly increased. Together these data are consistent with the idea that cMyBP-C creates an internal load in the sarcomere by binding to actin.
BOOK REVIEWS
Journal: British Journal of Dermatology (1980)

Abstract Book reviewed in this article: Histologic Diagnosis of Inflammatory Skin Diseases. A. Bernard Ackerman Immunological Aspects of Contact Sensitivity. Monographs in Ailergy, 15. L. Polak A Colour Atlas of Pathogenic Fungi. D. Frey, R.J.Oldfield AND R.C. Bridger The Mast Cell: Its Role in Health and Disease. Edited by J.Pepys AND A.M.Edwards The Mast Cell: Its Role in Health and Disease. Edited by J. Pepys and A. M. Edwards
AMERICAN PUBLIC HEALTH ASSOCIATION—A CORRECTION.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
<i>Erratum</i>: Vol. 63, No. SS-11
Journal: MMWR Morbidity and Mortality Weekly Report (2020)

In the Surveillance Summary "Abortion Surveillance -United States, 2011," data on the number of known previous induced abortions for women having abortions in this reporting year were erroneously included for New York City.These data did not meet reporting standards and should have been excluded from this report.When corrected, among women with abortions in the reporting year, the proportion with no previous induced abortions increased, and the proportion with one or more previous induced abortions decreased.On page 8, the first paragraph should have read "Data from the 37 areas that reported the number of previous abortions for women who obtained abortions in 2011 indicate that the majority (56.9%) had no previous abortions, 36.1% had one to two previous abortions, and 7.1% had three or more previous abortions (Table 19).Among the 30 reporting areas ¶ ¶ ¶ ¶ that provided data for the relevant years of comparison (2002 versus 2006, 2007 versus 2011, and 2010 versus 2011), the percentage of women who had one to two previous abortions was stable, although there was a decrease among women who had zero previous abortions and an increase among women who had three or more previous abortions.Among the areas included in this comparison, 57.8%, 36.0%, and 6.2% of women had zero, one to two, or three or more previous abortions, respectively, in 2002; by contrast, 57.0%, 35.9%, and 7.2% of women had zero, one to two, or three or more previous abortions, respectively, in 2011."New York City should have been included in the ¶ ¶ ¶ ¶ footnote, which lists reporting areas that were not included in these estimates.In Table 19, the line for New York City should be deleted.For the total line, the numbers and percentages should have read 229,909 (56.9), 102,612 (25.4), 43,159 (10.7), 28,593 (7.1), 404,273 (97.8).
<i>Hallucinations in the insane</i>. By Edward B. Lane, M. D., Assistant Physician to the Boston Lunatic Hospital. Reprinted from the<i>Boston Medical and Surgical Journal,</i>September 10, 1891
Authors: J. M. M.
Journal: American Journal of Psychiatry (1892)

in the amount of seclusion and restraint."It is predicted that in the future "greater attention will be paid to the medical and scientific aspect of insanity,"and that the ideal of the service will be attained in the spirit of the motto, "to cure the curable, and to brighten the lives of those that can not be cured."
TCT-406 Percutaneous Coronary Intervention in Left Main Coronary Artery Disease Concomitant With Acute Coronary Syndrome: Clinical Outcomes at Long-Term Follow-Up
Authors: Ricardo Concepcion-Suárez, Ignacio Sanchez-Perez, Alfonso Freites Esteves, Ariana Gonzálvez-García, Manuel Muñoz Garcia, Alfonso Morón Alguacil, Jorge Martinez del Río, Martin Negreira, Cristina Mateo-Gomez, Fernando Lozano
Journal: Journal of the American College of Cardiology (2021)
Homonymous Hemianopia
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Primary reninism with renal hamartomatous alteration
Authors: M. Hirose
Journal: JAMA (1974)

This is the eighth case of primary reninism so far reported, but it is unusual in that the patient was very young (10 years of age) and the tumor was very small (0.2×0.15 cm), without delineation, yet cure was effected quickly (in five months). The boy, first admitted with malignant hypertension, was thought to have a juxtaglomerular (JG) cell tumor because of typical findings for it: hypertension, hypokalemia, hyperaldosteronism, and unilaterally (right) elevated renal vein plasma renin activity (PRA), with no disparity or abnormality on nephrogram or renal angiogram. Right nephrectomy resulted in a prompt cure and return of PRA to normal levels, but no delineated tumor was found in the excised right kidney. Reexamination showed an extremely small (0.2×0.15 cm) circumscribed nodular lesion in the cortex, which consisted of a group of peculiar cells whose characteristics coincided with neither hemangiopericytoma nor Wilms tumor. Several explanations are possible for the histological findings. (<i>JAMA</i>230:1288-1292, 1974)
Highlights
Journal: JAMA (2017)

Neoplasm Risk in 5-Year Survivors of Childhood Cancer 814Childhood cancer treatment has been modifi ed over time with the hope of reducing the incidence of subsequent neoplasms.To learn whether the risk of new neoplasms has changed in recent decades, Turcotte and colleagues conducted a retrospective, multicenter cohort study of 23 603 survivors of childhood cancer in the United States and Canada.The investigators found that the risk of subsequent malignancies at 15 years after initial cancer diagnosis decreased for patients diagnosed in the 1990s in comparison with those diagnosed in the 1970s; the lower risk was associated with reductions in the dose of therapeutic radiation. CME jamanetworkcme.com Complications of Type 1 vs Type 2 Diabetes 825Prior studies have suggested that adolescents and young adults with type 2 diabetes may be more likely than those with type 1 diabetes to have adverse health outcomes.In this article describing an observational study of 2018 participants diagnosed with diabetes before age 20 years, Dabelea and colleagues report that the prevalence of diabetic kidney disease, retinopathy, and other complications and comorbidities was greater in patients with type 2 diabetes than in patients with type 1 diabetes, but frequent in both groups.Their fi ndings support early monitoring of these patients for development of complications.CME jamanetworkcme.com
Urinary 5-Hydroxyindoleacetic Acid Excretion in Scleroderma
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Value of Nitroglycerin in Angina Pectoris
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
JAMA Neurology
Journal: JAMA Neurology (2017)

The mission of JAMA Neurology is to publish scientifi c information primarily important for those physicians caring for people with neurologic disorders but also for those interested in the structure and function of the normal and diseased nervous system.These specifi c aims are (1) to make timely publication of original research of the nervous system, (2) to record observations of single patients or groups of patients that will provide new information and insights,(3) to report more basic research that is pertinent to the understanding of disease, (4) to introduce topics of practice, ethics, teaching, and history that are useful, and (5) to provide a forum for discussion on topics that may be controversial in this fi eld.This information will be published only after extensive peer review so that originality, clarity, and precision are ensured.
Hysteria
Authors: S. W Brown
Journal: Journal of the Royal Society of Medicine (2006)

JRSM 1 ) rightly draw attention to the undue influence on a general medical readership of Eliot Slater's 1965 paper on hysteria.However, it is perhaps misleading to describe it as 'a blessing for psychiatrists'.In fact, a sensible psychiatric response which was highly influential on subsequent psychiatric practice was Aubrey Lewis's classic paper 'The survival of hysteria', 2 which pips Stone et al. to the post by 30 years; and which surely must be read alongside Slater.Besides writing a general homily on the subject, Lewis reported a series of 98 patients who had received diagnosis of hysteria at the Maudsley Hospital, with follow-up from 7-12 years, but with somewhat different findings to Slater ('. . . in very few did this raise the question of an altered diagnosis').Of course, Lewis's series came from a psychiatric hospital and Slater's from a neurological one, causing him to state of his results, 'That they are not similar to the findings on patients diagnosed at a neurological hospital is not surprising'.Indeed it is not.The implication that did not escape those of us for whom both Slater and Lewis were required reading in our psychiatric training, was that psychiatric diagnoses made in psychiatric settings may be more robust than psychiatric diagnoses made in neurological settings.The paper ends with one of Lewis's celebrated aphorisms ' . . .a tough old word like hysteria dies very hard.It tends to outlive its obituarists'.Unfortunately, it seems the same cannot be said for Lewis's huge contribution.
Medical News
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Comparative Neurobehavioral Study of a Polybrominated Biphenyl-Exposed Population in Michigan and a Nonexposed Group in Wisconsin
Authors: Jose A. Valciukas, Ruth Lilis, Mary S. Wolff, Henry A. Anderson
Journal: Environmental Health Perspectives (1978)

An analysis of findings regarding the prevalence and time course of symptoms and the results of neurobehavioral testing among Michigan and Wisconsin dairy farmers, is reported. Reviewed are: (1) differences in the prevalence of neurological symptoms at the time of examination; (2) differences in the incidence and time course of symptoms for the period 1972--1976; (3) differences among populations and subgroups (sex and age) regarding performance test scores; (4) correlations between performance test scores and neurological symptoms; and (5) correlations between serum PBB levels as indicators of exposure and performance tests and neurological symptoms.
Medical uses of the orthopantomogram
Authors: J. S. Panella
Journal: JAMA (1979)

ORTHOPANTOMOGRAPHY is a roentgenographic technique allowing examination of the entire dentoalveolar region on a single film. It is used primarily as a rapid screening examination to show the general anatomic relationships of the maxilla, mandible, and adjacent structures. Although dental films provide much finer detail, the orthopantomogram is a simple, rapid, and comfortable examination that can provide useful information on a wide variety of pathological processes with less cost and radiation exposure than the conventional full-mouth periapical series.<sup>1</sup>The orthopantomogram is obtained with the patient standing or sitting with the alveolar ridge parallel to the floor. Only a single exposure is required, during which the x-ray tube makes a sweep about the patient's head. Although a wide variety of lesions can be well demonstrated by this examination, appreciation of its uses has been largely limited to those in dentistry and oral surgery. Medical uses of the orthopantomogram are numerous
RENAL CALCULI AND CALCIUM METABOLISM
Authors: H. J. Johnston-Lavis
Journal: BMJ (1911)

TLRs are a group of pattern-recognition receptors that play a crucial role in danger recognition and induction of the innate immune response against bacterial and viral infections. The TLR adaptor molecule, Toll/IL-1R domain-containing adaptor inducing IFN (TRIF), facilitates TLR3 and TLR4 signaling and concomitant activation of the transcription factors, NF-κB and IFN regulatory factor 3, leading to proinflammatory cytokine production. Whereas numerous studies have been undertaken toward understanding the role of TRIF in TLR signaling, little is known about the signaling components that regulate TRIF-dependent TLR signaling. To this end, TRIF-interacting partners were identified by immunoprecipitation of the TRIF signaling complex, followed by protein identification using liquid chromatography mass spectrometry. Following stimulation of cells with a TLR3 or TLR4 ligand, we identified a disintegrin and metalloprotease (ADAM)15 as a novel TRIF-interacting partner. Toward the functional characterization of the TRIF:ADAM15 interaction, we show that ADAM15 acts as a negative regulator of TRIF-mediated NF-κB and IFN-β reporter gene activity. Also, suppression of ADAM15 expression enhanced polyriboinosinic polyribocytidylic acid and LPS-mediated proinflammatory cytokine production via TRIF. In addition, suppression of ADAM15 expression enhanced rhinovirus 16 and vesicular stomatitis virus–mediated proinflammatory cytokine production. Interestingly, ADAM15 mediated the proteolytic cleavage of TRIF. Thus, ADAM15 serves to curtail TRIF-dependent TLR3 and TLR4 signaling and, in doing so, protects the host from excessive production of proinflammatory cytokines and matrix metalloproteinases. In conclusion, to our knowledge, our study clearly shows for the first time that ADAM15 plays an unexpected role in TLR signaling, acting as an anti-inflammatory molecule through impairment of TRIF-mediated TLR signaling.