tbuckley/cabot-search huggingface dataset:
Update: Influenza Activity, 1992
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A CHINESE EDDYITE.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Whipple Disease
Authors: Joseph W. Griffin
Journal: JAMA (1976)

<h3>To the Editor. —</h3> The case report by DeLuca et al (233:59, 1975) of Whipple disease in a white patient older than the expected age, who also had a prolonged prodromal arthritis, prompts our reporting two cases of Whipple disease seen at the Eugene Talmadge Memorial Hospital in the past 12 years. Both cases illustrate unusual features of Whipple disease: a woman in whom the initial manifestation was fever of undetermined origin and a black man with prolonged arthritis. <h3>Report of Cases.—Case 1.—</h3> A 61-year-old white woman who had fever of undetermined origin for seven years was discovered at autopsy to have Whipple disease. Her work-up had included an exploratory laparotomy five years before death at an outside hospital and an evaluation at a major diagnostic center one year prior to death. Symptoms seven years prior to admission were postprandial abdominal bloating, constipation for two to three days followed
Phosphorus Poisoning in Humans
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Manuscripts Approved for JNCI, June 1 to July 1, 1969
Journal: JNCI Journal of the National Cancer Institute (1969)

Journal Article Manuscripts Approved for JNCI, June 1 to July 1, 1969 Get access JNCI: Journal of the National Cancer Institute, Volume 43, Issue 2, August 1969, Pages 517–519, https://doi.org/10.1093/jnci/43.2.517-a Published: 01 August 1969
Proteinuria
Authors: George Dunea
Journal: JAMA (1968)

The presence of protein in the urine was detected by Frederick Dekkers of Leyden in 1694, found in dropsical patients by Cotugno in 1764, and related to renal disease by Richard Bright in 1827. It remains to this day the most important and often the most sensitive sign of renal disease. Most healthy subjects excrete less than 100 mg of protein per 24 hours, but less rigid criteria are employed in clinical practice. In the present state of knowledge, quantities less than 250 mg/24 hr are best regarded as normal for employment and insurance purposes. Excretion of protein in excess of 300 mg/24 hr, unless associated with transient physiological or pathological states, is indicative of kidney disease.<sup>1</sup>The converse however does not always hold true; disorders such as renal artery stenosis, pyelonephritis, obstructive uropathy and, at times, glomerulonephritis may occur in the absence of proteinuria. Intermittent or orthostatic proteinuria
Abstract 74: Heterogeneity response to afatinib in gastric cancer patient with uncommon EGFR mutations
Authors: Qin Liu, Jia Wei, Yang Yang, Yue Wang, Baorui Liu, Yang Shao
Journal: Cancer Research (2019)

Abstract Introduction: Gastric cancer is the third leading cause of cancer mortality worldwide. Gatric cancer based on driver gene mutation detection may benefit patients by facilitating molecular targeted drugs development and improving survival in gastric cancer patients. On the other hand, the complex and heterogeneous molecular mechanisms of gastric cancer also plays an essential role in the drug resistance. Methods: Whole exome sequencing (WES) was performed, revealing uncommon EGFR ex21 L861Q and ex18 G719S mutation of formalin-fixed paraffin-embedded sections from primary tumor and different metastatic lesions in a gastric cancer patient. The periodic circulating tumor DNA (ctDNA) was also determined by next generation sequencing (NGS). Stable gastric cancer cell and NIH-3T3 cell lines harboring the mutations were established to investigate the effect and mechanisms. Results: Tumors with compond EGFR L861Q/G719S mutations and EGFR gene amplfication are sensitive to afatinib, which caused tumor progression in short time. However, the lung metastatic lesion, which lacked EGFR gene amplification demonstrated primary resistance to afatinib. A dramatic increase of MET gene copy number may collectively related to the patient’s rapid progression. Periodic mutation profiling of patient’s ctDNA by NGS correspondingly revealed compond EGFR L861Q/G719S mutations, and a consitent increase of MET gene amplification. In in vitro studies, afatinib treatment reduced proliferation and inhibited EGFR phosphorylation in L861Q/G719S and L861Q mutant cells. Conclusions: Afatinib may be a beneficial therapeutic option for a subset of gastric cancer patients with rare EGFR mutations in their tumors. Our results also illustrated the great potential of ctDNA profiling for treatment decision-making to patients with gastric cancer. Note: This abstract was not presented at the meeting. Citation Format: Qin Liu, Jia Wei, Yang Yang, Yue Wang, Baorui Liu, Yang Shao. Heterogeneity response to afatinib in gastric cancer patient with uncommon EGFR mutations [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 74.
Highlights
Journal: JAMA (2013)

Aliskiren and Coronary Artery Disease Progression 1135Renin inhibition has a protective effect against atherosclerosis in animal models.To assess the effect of renin inhibition on progression of coronary atherosclerosis in humans, Nicholls and colleagues randomly assigned 613 patients with coronary artery disease and systolic blood pressure in the prehypertensive range (between 125 and 139 mm Hg) to receive aliskiren-a renin inhibitor-or placebo for 2 years.Participants underwent coronary intravascular ultrasound at baseline and after treatment to assess change in atheroma volume, and the authors found that compared with placebo, use of aliskiren did not result in regression or slowing of progression of coronary atherosclerosis.In an Editorial, Tardif and Grégoire discuss renin-angiotensin system inhibition and secondary prevention of cardiovascular disease. Related Editorial 1130 Otamixaban for Non-ST-Segment Elevation ACS 1145The optimal anticoagulant for patients with non-ST-segment elevation acute coronary syndromes (NSTE-ACS) managed with an invasive strategy is not clear.In a randomized trial that enrolled 13 229 patients with NSTE-ACS who were undergoing planned early percutaneous coronary intervention (PCI), Steg and colleagues found that otamixaban-a novel intravenous direct factor Xa inhibitor-did not reduce the rate of ischemic events but did increase bleeding compared with unfractionated heparin plus eptifibatide.
Ligations of the Left Subclavian Artery in Its First Proportion.
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Adjuvant whole-brain radiotherapy versus observation after radiosurgery or surgical resection of 1–3 cerebral metastases: Results of the EORTC 22952–26001 study
Authors: R. P. Mueller, R. Soffietti, M. U. Abaciouglu, S. Villa, F. Fauchon, B. G. Baumert, L. Fariselli, T. Tzuk-Shina, L. Collette, M. Kocher
Journal: Journal of Clinical Oncology (2009)

2008 Background: The EORTC Radiotherapy and Brain Tumor Groups conducted a phase III trial to define the role of adjuvant whole brain irradiation (WBRT) after local treatment (surgery or radiosurgery) for brain metastases. It was hypothetized that WBRT would increase the duration of functional independence by reducing the number of intracranial relapses. Methods: Pts eligible for radiosurgery (RS) had 1–3 metastases of solid tumors (SCLC excluded) ≤ 3.0 cm in diameter (≤ 2.5 cm for 2–3 lesions). In case of surgery (S), a complete resection was mandatory. Only pts with no or stable systemic disease or with asymptomatic synchronous primary tumors, and with WHO PS 0–2 were allowed. Pts were randomized for adjuvant WBRT or observation (OBS). Primary endpoint was survival with functional independence measured by the time to WHO PS deterioration to &gt; 3. Analysis is by intent-to-treat (Logrank, two-sided α = 0.05). Results: From 1996–2007, 359 pts were recruited. 160 surgical pts had resection of one (96%) or two (4%) metastases, and 185 (of 199 scheduled pts) had RS (marginal dose 20Gy, target dose 25Gy) of one (67%), two (23%), or three (10%) lesions. Adjuvant whole brain irradiation (30Gy/10 fractions) was given to 166/180 pts. (92%) randomized for WBRT and to 4/179 pts (2%) in the OBS arm. Median time to WHO PS &gt; 3 was 9.8 months (95% CI 8.0 - 11.7) in the OBS arm and 9.8 months (95% CI 7.8 - 12.6) in the WBRT arm (p &gt; 0.5). It was only significantly influenced by initial WHO PS and initial systemic disease status (p &lt; 0.01). Overall survival was 10.9 months (95% CI 9.2 - 14.6) in both arms (p &gt; 0.5). Cumulative incidence of intracranial progression at 6 and 24 months was 39.7% (95% CI 32.5 - 46.8) and 54.0% (95% CI 46.7 - 61.3) of the OBS pts, but only 15.2% (95% CI 9.9 - 20.5) and 31.4% (95% CI 24.5 - 38.2) of the WBRT pts (p &lt; 0.0001). Intracranial progression was a cause of the death in 77/179 pts (43%) of the OBS group and in only 45/180 pts (25%) of the WBRT group. Conclusions: After radiosurgery or surgery of 1–3 brain metastases, adjuvant WBRT reduces the frequency of intracranial relapses and neurologic deaths but fails to prolong the time period of functional independence and overall survial time. Updated results will be presented at the Meeting. No significant financial relationships to disclose.
Dose-Response Between Exogenous Cortisone Acetate and Urinary Excretion of Trypsin Inhibitor in Man
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Practical Uranalysis and Urinary Diagnosis: A Manual for the Use of Physicians, Surgeons and Students.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Human Infertility
Authors: Fred A. Simmons
Journal: New England Journal of Medicine (1956)

INFORMATION from reliable sources indicates that for every 85 couples producing one or more living offspring, there are still 15 couples in this progressive country who do not conceive. Therefore, modern medicine must concern itself with the challenge of what can be done for more than 3,000,000 involuntarily childless married couples in the United States. Indeed, this is a world-wide problem. Since the founding of the American Society for the Study of Sterility, only thirteen years ago, groups of physicians, specialists, psychiatrists and veterinarians interested in promoting human reproduction have been formed all over the globe. At least three journals, . . .
Terminal ileal biopsy, small bowel imaging and upper-gi endoscopy are all required for the efficient diagnosis of paediatric-onset crohn's disease
Authors: R. J. Dart, R. K. Russell, K. Al-Hourani, J. Read, P. Rogers, P. M. Gillett, D. C. Wilson
Journal: Gut (2011)

<h3>Introduction</h3> In contrast to adult-onset Crohn9s disease (CD), presentation of paediatric-onset CD (PCD) is characterised by widespread intestinal involvement; hence guidelines for diagnosis of PCD recommend evaluation of the GI tract by upper-gastrointestinal endoscopy (UGIE), colonoscopy with terminal ileal (TI) biopsy and small-bowel imaging (SBI). We aimed to establish the contribution of each part of this evaluation to the diagnosis of PCD. <h3>Methods</h3> We performed a retrospective cohort study of all 159 PCD cases (diagnosis &lt;17 years of age) in our regional centre from 1 July 1997 to 1 September 2009 using case note and database review. 109 PCD patients had full endoscopic examination at first presentation including attempted TI biopsy, UGIE and SBI (barium follow-through or MRI). Location of PCD defining granulomatous or characteristic inflammation was recorded, in contrast to non-specific classical features of IBD (diagnostic for IBD not PCD). Statistical analysis was performed using Fisher9s Exact test. <h3>Results</h3> Data were available for 105/109 (96%) patients with PCD undergoing full GI tract evaluation at initial diagnosis. 58 (55%) patients had upper GI involvement. TI biopsy was achieved on 66 (63%) occasions. Histopathological defining features of PCD in the TI alone were present in 7 (11%) cases. PCD was diagnosed by SBI alone, where biopsies were non-diagnostic, in 10 (10%) cases, including 3 (5%) of 66 cases where TI biopsy was achieved. Defining features of PCD were seen in UGIE alone in 8 (8%); 7/8 cases included TI biopsy that was not diagnostic. Two patients had non-specific GI inflammation but granulomatous inflammation involving the skin. Sensitivity of colonoscopy alone (without TI biopsy) was 74% for PCD. Sensitivity of colonoscopy and TI biopsy alone (where TI intubation was achieved) was 83% (p=0.2). The addition of TI biopsy and/or SBI to colonoscopy improved sensitivity to 90% (p=0.003) and sensitivity again significantly improved to 98% (p=0.03) when UGIE was added. <h3>Conclusion</h3> Differentiation of PCD from ulcerative colitis and IBDU requires correlation of clinical, endoscopic, pathological and radiological findings. Our data support the recommendation by BSPGHAN1 that children suspected of IBD should have complete evaluation of the GI tract at diagnosis. Many children undergo endoscopic evaluation by adult gastroenterologists, more accustomed to the adult distribution of disease, and who may be tempted to forgo full ileocolonoscopy and UGIE. Our data demonstrate that these tests are vital to significantly improve diagnostic yield in PCD.
Coding Error in Meta-analysis
Authors: Eric Coon, Ricardo Quinonez, Alan Schroeder
Journal: JAMA Pediatrics (2018)

Zhen Wang, PhD; Stephen P. H. Whiteside, PhD, LP; Leslie Sim, PhD, LP; Wigdan Farah, MBBS; Allison S. Morrow, BA; Mouaz Alsawas, MD, MSc; Patricia Barrionuevo, MD; Mouaffaa Tello, MD; Noor Asi, MD; Bradley Beuschel, BSPH; Lubna Daraz, PhD; Jehad Almasri, MD; Feras Zaiem, MD; Laura Larrea-Mantilla, MD; Oscar J. Ponce, MD; Annie LeBlanc, PhD; Larry J. Prokop, MLS; Mohammad Hassan Murad, MD, MPH
Obituaries
Journal: JAMA (1980)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SEBORRHCEIC SYCOSIS*
Authors: JOHN T. INGRAM
Journal: British Journal of Dermatology (1938)

Journal Article SEBORRHCEIC SYCOSIS Get access JOHN T. INGRAM, M.D., F.R.C.P. JOHN T. INGRAM, M.D., F.R.C.P. Physician in Charge of the Skin‐Department, General Infirmary, Leeds Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 50, Issue 2, 1 February 1938, Pages 59–66, https://doi.org/10.1111/j.1365-2133.1938.tb10473.x Published: 01 February 1938
Tapping into 'procedural' memory helps patients with amnesia to acquire new occupational skills
Authors: T. F. Kirn
Journal: JAMA (1987)

WHEN A TORONTO company had to phase out the clerical job of a severely amnesic woman employee, it decided first to consult the University of Toronto's Unit for Memory Disorders. Company officials hoped that if the woman could be trained for a new job, she might be spared the financial and emotional hardship of being let go. To Daniel Schacter, PhD, and Elizabeth Glisky, PhD, of the Unit for Memory Disorders, that 32-year-old woman, whom they refer to as H.D., presented both a challenge and an opportunity. The woman—who became amnesic in June 1980 after contracting herpes simplex encephalitis—was familiar to them from having participated in experimental studies of memory at the center. The woman's IQ was 84, and she had performed extremely poorly on the Wechsler Memory Scale test. Thirty minutes after testing, she was unable to recall anything of the stories, line drawings, or tasks of the test.