tbuckley/cabot-search huggingface dataset:
NAFLD and NASH: important diseases before and after liver transplantation
Authors: A YU, E KEEFFE
Journal: Hepatology (2001)

Many subjects with cryptogenic cirrhosis have underlying nonalcoholic steatohepatitis (NASH). The natural history of NASH-related cryptogenic cirrhosis after orthotopic liver transplantation (OLT) is not well defined.A primarily retrospective study of patients with the clinical histological phenotype of NASH-related cirrhosis undergoing OLT was performed.Data were compared with 2 sets of age-and weight-matched controls with (1) primary biliary cirrhosis or primary sclerosing cholangitis or (2) alcoholic liver disease.After OLT, all patients were managed by a standard immunosuppressive protocol.Liver biopsies were performed at 6 and 12 months after OLT and at 1-to 2-year intervals thereafter, as well as when liver enzyme levels were elevated enough to warrant diagnostic biopsy.Twentyseven subjects with cryptogenic cirrhosis and a clinical histological phenotype of NASH and 3 patients with a longstanding diagnosis of NASH before OLT were included.The 30-day perioperative mortality was 1 in 30 patients.During a median follow-up of 3.5 ؎ 2.7 years, 2 additional patients died of sepsis.There was a time-dependent increase in the risk for allograft steatosis that approached 100% by 5 years compared with only an approximately 25% incidence of steatosis in the control groups (P < .009,log-rank test).On multivariate analysis, only the cumulative steroid dose correlated with time to development of allograft steatosis.Three patients developed histological progression from hepatic steatosis to steatohepatitis.Of these, 1 patient developed progressive fibrosis.Four patients experienced at least 1 episode of acute cellular rejection; however, no patient developed chronic rejection or graft failure.In conclusion, nonalcoholic fatty liver disease occurs frequently after OLT in patients with the phenotype of NASH-related cirrhosis.Despite the frequent histological recurrence of disease, clinical outcomes are similar to those of other groups of patients undergoing OLT. COMMENTS
Antitrust and hospital privileges. I. Federal jurisdictional requirements
Authors: W. J. Tabor
Journal: JAMA (1984)

TO INVOKE the jurisdiction of a federal court over the subject matter of a lawsuit under the Sherman Antitrust Act, a plaintiff physician must demonstrate a logical connection between a denial of privileges and interstate commerce. Ordinarily, a defendant's anticompetitive conduct is subject to Sherman Act scrutiny if it has occurred "within the flow of commerce" or if it has "substantially affected interstate commerce."<i>Hospital Building Co v Trustees of Rex Hospital</i>, 425 US 738, 743 (1976). Since denials of privileges usually relate only to local markets for medical services rather than to interstate transactions, the first test rarely applies in hospital privilege controversies. The federal courts have adopted various approaches with respect to the nature and extent of impact that suffices to establish jurisdiction under the "effect on commerce" test, although a consensus position recently has begun to emerge. Until recently, federal courts remained unconvinced that denials of privileges
Countdown Zero
Authors: Clark W. Heath
Journal: JAMA (1984)

The development of nuclear weapons in this country involved numerous atmospheric test explosions in the 1950s, both at the Nevada Test Site and in the Pacific. Military personnel were often present at tests as observers or as participants in war maneuvers designed to give the armed forces direct experience with nuclear combat conditions. These events, vividly portrayed in this book through the recollections of men who were there as young soldiers, provide gripping testimonials to the destructive force of nuclear war. The impact of these nuclear military experiences on the subsequent lives of the men involved is hard to know, and it deserves close medical attention. Risk of radiation-caused illness, including cancer, is an obvious concern, but it is one that is closely dependent on radiation dose. Existing information suggests that exposure levels for the most part were low. Uncertainty exists, however, especially in relation to internal radiation exposure from
THE PARATHYROID HORMONE—A WARNING
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Carcinogenicity of Airborne Fine Particulate Benzo(a)pyrene: An Appraisal of the Evidence and the Need for Control
Authors: F. Perera
Journal: Environmental Health Perspectives (1981)

Benzo(a)pyrene(BaP) originating from fossil fuel and other organic combustion processes is largely adsorbed on fine particulate and hence is a widespread atmospheric pollutant. Available emissions and air quality data are based on the total weight of particulate matter without reference to size and give little information on trends and concentrations of fine particulate BaP. Greater reliance on coal, synfuels and diesel fuel for energy production and transportation will significantly increase ambient levels of BaP. Because of the particulate size, BaP is substantially deposited in the lower lung and readily eluted into surrounding tissue. After elution in the lung, BaP is metabolically activated to its electrophilic, carcinogenic from by a complex enzyme system whose activity is increased by prior exposure to air pollutants, cigarette smoke and certain drugs. The resultant diol epoxide metabolite has been shown to bind covalently with the DNA of the lung. In experimental animals, BaP is a potent initiating carcinogen whose action is enhanced by sulfur dioxide, promoting agents and carrier fine particles. The effect of small, divided doses of BaP has been shown to be greater than that of a single high dose; no threshold has been established. Epidemiological studies show that mixtures containing BaP (such as urban air, industrial emissions and cigarette smoke) are carcinogenic and may interact synergistically. Occupational studies indicate that the action of BaP-containing mixtures is enhanced in the presence of SO2. However, quantitative risk assessment for BaP is precluded by problems in extrapolating to the general population from small-scale animal studies; uncertainties in findings of epidemiology; and imprecise exposure data. Existing stationary and mobile controls preferentially remove coarse particulate matter and are inefficient collectors of the particulate BaP. In the current absence of health and environmental standards for BaP, there is little incentive to control BaP emissions. BaP meets the criteria for regulation under the Clean Air Act; however, no such BaP standards have yet been proposed.
Distinctive Biochemical Pattern Associated with Resistance of Hepatocytes in Hepatocyte Nodules during Liver Carcinogenesis
Authors: L. Eriksson, M. Ahluwalia, J. Spiewak, G. Lee, D. S. R. Sarma, M. J. Roomi, E. Farber
Journal: Environmental Health Perspectives (1983)

Hepatocyte (“hyperplastic”) nodules induced in the liver by initiation with diethylnitrosamine and selected by dietary 2-acetylaminofluorene plus partial hepatectomy (“resistant hepatocyte model”) have a special pattern of biochemical behavior and metabolic activity different than that seen acutely with many xenobiotics including many promoting agents and carcinogens. The nodule cells show a very low uptake of 2-acetylaminofluorene, relative to surrounding and normal liver, low levels of activity in the cytochromes P-450 and aryl hydrocarbon hydroxylase, high levels of activity in γ-glutamyltransferase, microsomal epoxide hydrolase, soluble glutathione-S-transferase and soluble UDP-glucuronyltransferase (UDP-GT1) and elevated levels of glutathione. This metabolic pattern appears to maximize the resistance of the nodules to xenobiotics generally, such as 2-acetylaminofluorene, and thereby may account for the resistant behavior of nodule hepatocytes to the inhibition of cell proliferation and the cytotoxicity by 2-acetylaminofluorene and other carcinogens. The possible importance of this seemingly new metabolic program in carcinogenesis is discussed briefly.
DANGER FROM SLEEPING CARS.
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Enhanced survival of lung granulocytes in an animal model of asthma: evidence for a role of GM-CSF activated STAT5 signalling pathway
Authors: R K Turlej, L Fiévez, C F Sandersen, S Dogné, N Kirschvink, P Lekeux, F Bureau
Journal: Thorax (2001)

BACKGROUND As granulocyte/macrophage colony stimulating factor (GM-CSF) mediated delay of granulocyte apoptosis contributes to the accumulation of inflammatory cells at the site of inflammation in many diseases, we sought to determine whether asthma is also associated with a GM-CSF dependent increase in lung granulocyte survival. Moreover, because GM-CSF mediates its effects through activation of signal transducer and activator of transcription 5 (STAT5), we also investigated the potential role of STAT5 in allergic inflammation. METHODS Blood granulocytes were recovered from six healthy and six heaves affected horses, a model of asthma. Lung granulocytes were obtained by bronchoalveolar lavage (BAL) from the same horses. Granulocytes were cultured in the presence or absence of anti-GM-CSF receptor antibodies for different times and apoptosis was determined using the Annexin-V/propidium iodide detection method. Nuclear protein extracts from cultured granulocytes were analysed for STAT5 binding activity by electrophoretic mobility shift assay. RESULTS BAL fluid granulocytes from heaves affected horses demonstrated a significant delay in apoptosis compared with blood granulocytes from the same horses and blood and BAL fluid granulocytes from healthy horses. Conversely, the rate of apoptosis in blood granulocytes from healthy and heaves affected horses was comparable. The enhanced survival of BAL fluid granulocytes from affected horses was suppressed in the presence of antibodies directed against GM-CSF receptors. Increased levels of active STAT5 were found in BAL fluid granulocytes from heaves affected horses and were markedly reduced after treatment with anti-GM-CSF receptor antibodies. CONCLUSIONS These data indicate that granulocyte survival is enhanced in the lung of heaves affected horses and suggest a role for a GM-CSF activated STAT5 pathway in delaying apoptosis of lung granulocytes in this model of asthma.
February 18, 2003
Authors: James T. Willerson
Journal: Circulation (2003)

is the Section Editor for Circulation's newest section, Mini-Reviews: Expert Opinions.Expert opinions and advice will be solicited from internationally recognized thought-leaders for topics in cardiovascular medicine that are of interest to the cardiovascular clinician.In addition, health-care policy and patient care issues will be examined attempting to improve clinical care and resource utilization.Mini-
Early Results Promising for LDK378 in ALK-positive NSCLC
Journal: Cancer Discovery (2013)

Abstract The Novartis second-generation ALK inhibitor LDK378 showed an overall response rate of 60% in a phase I trial involving 130 patients with ALK-positive non–small cell lung cancer. Both patients who had never received a targeted therapy and those who had become resistant to crizotinib responded to the drug.
Government Services
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
JOURNAL OF THE NATIONAL CANCER INSTITUTE
Journal: JNCI Journal of the National Cancer Institute (1990)

Journal Article JOURNAL OF THE NATIONAL CANCER INSTITUTE Get access JNCI: Journal of the National Cancer Institute, Volume 82, Issue 2, 17 January 1990, Pages 161–163, https://doi.org/10.1093/jnci/82.2.161 Published: 17 January 1990
Film Reviews
Journal: JAMA (1961)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ulcerative and "Granulomatous" Colitis—Validity of Differential Criteria: A Study of 100 Patients Treated by Total Colectomy.
Authors: M. J. Goldstein
Journal: Annals of Internal Medicine (1969)

s1 May 1969Ulcerative and "Granulomatous" Colitis—Validity of Differential Criteria: A Study of 100 Patients Treated by Total Colectomy.M. J. Goldstein, M.D., F.A.C.P., H. Schachter, M.D., H. Rappaport, M.D., F.A.C.P., J. J. Fennessy, M.D., J. B. Kirsner, M.D., F.A.C.P.M. J. Goldstein, M.D., F.A.C.P.Search for more papers by this author, H. Schachter, M.D.Search for more papers by this author, H. Rappaport, M.D., F.A.C.P.Search for more papers by this author, J. J. Fennessy, M.D.Search for more papers by this author, J. B. Kirsner, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-70-5-1067_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOne hundred patients with inflammatory disease of the colon treated by total colectomy during 1936-67 were subjected to independent clinical, pathologic, and radiologic restudy. Twenty-one of the 100 patients were diagnosed clinically as having Crohn's disease ("granulomatous" colitis), with X-ray agreement in 18 cases. Only 6 of the 21 patients presented cumulative histologic features of granulomatous colitis, although even in these cases co-existent histologic features of ulcerative colitis were noted. Granulomas were found in 11 of the 21 patients, fissures or clefts in 3, and lymphangiectasis in none. Seventy-nine of the 100 patients were diagnosed clinically as having ulcerative colitis,... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: M. J. Goldstein, M.D., F.A.C.P.; H. Schachter, M.D.; H. Rappaport, M.D., F.A.C.P.; J. J. Fennessy, M.D.; J. B. Kirsner, M.D., F.A.C.P.Affiliations: Chicago, Illinois PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1969Volume 70, Issue 5Page: 1067-1068KeywordsColectomyColitisColonCrohn's diseaseGranulomasUlcerative colitis ePublished: 1 December 2008 Issue Published: 1 May 1969 PDF downloadLoading ...
Assessment of the patient with suspected endocarditis
Authors: A. M. Hutter
Journal: JAMA (1976)

IN CONSIDERING the patient with possible infective endocarditis, the medical history and physical examination are of paramount importance, for it is the clinical presentation that usually provides the initial clues to the diagnosis. The majority of cases of infective endocarditis still occur in the setting of underlying rheumatic or congenital heart disease, although the 40% to 60% of cases currently falling into this category are much less than the 80% to 90% of cases seen in earlier years.<sup>1,2</sup>A number of other lesions including calcific aortic stenosis and other forms of degenerative heart disease, idiopathic hypertrophic subaortic stenosis (asymmetrical septal hypertrophy), and mitral valve prolapse ("click-murmur" syndrome) may serve as the substrate for infective endocarditis. In recent years, increasing numbers of cases are found superimposed on prosthetic heart valves. Even normal heart valves can become infected, as in acute bacterial endocarditis due to<i>Staphylococcus aureus</i>. Fever is present in
Communication
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Coagulation, Hemorrhage and Thrombosis
Authors: Benjamin Alexander
Journal: New England Journal of Medicine (1955)

Genetic aspects of hemophilia. A great contribution to knowledge of human hemophilia has been made by Brinkhous and his colleagues,91 ,91a who have extensively studied a hemorrhagic disorder in dogs that completely simulates the classic disease. The abnormality, which arose de novo in a strain of Irish setters,‡ has been maintained by inbreeding and by prompt, frequent and prophylactic transfusion with normal blood to bring the animals through their hazardous puppyhood. Many observations in this species agree remarkably with those in man.59 In addition to basic information concerning the defect of hemophilia, studies in the dog have yielded valuable genetic . . .
I. ANTISTREPTOCOCCUS SERUM AND STREPTOCOCCUS VACCINES
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal