tbuckley/cabot-search huggingface dataset:
Participation of epileptic patients in sports
Authors: S. Livingston
Journal: JAMA (1973)

The athletic privileges of young people with epilepsy are often restricted by parents because of fear that injury might "make the epilepsy worse," or that resulting fatigue may precipitate further seizures, or both. The public in general tends to share these views; fortunately, many physicians and educators today believe that once a patient's seizures are under reasonable control, he should lead a normal life and participate in sports and other physical activities. We have encountered many instances where parents of a child who had experienced only an occasional seizure considered him ill in the same respect as if he were afflicted with active tuberculosis or acute rheumatic fever. These children were encouraged and frequently compelled to rest and take daily afternoon naps. These attitudes should be discouraged, since they are medically unsound and often do the patient more harm than good. The parents should be instructed to allow their children
A Simple Approach to Relieve Teens’ Anxiety and Depression
Journal: JAMA (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medical education.
Authors: S. Brearley
Journal: BMJ (1992)

Details ofpatients on referral to ophthalmologist Time from start of Visual acuity on referral* Intraocular pressure Final visual acuity* nebulisers to onset of on referral Delay to referral Case No Age (years)ocular symptoms Right eve Left eye (mm Hg (kPa)) (hours) Right eye Left eye 1 68 24 h 6/24t Count fingerst 60 (8 0) 24 6/9 6/9 52 (6 9) 2 67 1 h Count fingerst 6/9 64 (8-5) 72 6/36 6/9 22 (2 9) 3 69 36 h 6/60t 6/6 45 (6-0) 72 6/36 6/6 29 (3-9) 4 70 24 h Hand Hand 55 (7 3) 24 Hand 6/24 movementt movementt 48 (6-4) movement 5 78 9 days 6/36t 6/36t 60 (8-0) None 6/12 6/9 48 (6-4) *Measured by Snellen's test.t Eve with acute angle closure glaucoma.cholinergic activity (for example, amitriptyline in case 3) may aggravate the problem.No cases of acute angle closure glaucoma have been reported with inhaled ipratropium or salbutamol.The higher doses achieved by nebulised administration and the fact that the drugs may escape around the mask and enter the eye probably account for their ability to cause acute angle closure glaucoma when administered with a nebuliser.A study on patients with chronic bronchitis showed that when ipratropium bromide and salbutamol were administered simultaneously with a nebuliser intraocular pressure increased in all patients with narrow drainage angles.3Transient angle closure occurred in half of these patients, although none required ophthalmic intervention.The use of goggles prevented the rise in intraocular pressure during nebulised administration of these drugs.
Radiology
Authors: R. G. Evens
Journal: JAMA (1991)

The expanding capabilities and uses of diagnostic imaging continue to be driven by advances in technology<i>and</i>an increasing understanding of the appropriate application of technology to patient care. Exciting diagnostic radiology developments in the past year were usually associated with technical, but not necessarily new, procedures. For example, mammography, a technique originating in the 1950s, is now the most rapidly growing diagnostic procedure. Previous investigations have demonstrated the effectiveness of mammography screening in early detection of breast cancer, and promotional efforts by many medical, governmental, and private organizations have influenced a growing number of women to obtain mammograms, resulting in a dramatic increase in the number of imaging procedures. A current focus is to improve the quality of mammography practices<sup>1</sup>by analysis of the technical image and the professional interpretation. One review<sup>2</sup>of 27 000 mammography screening procedures reported a sensitivity and specificity of more than 90%
Burdock root tea poisoning. Case report involving a commercial preparation
Authors: P. D. Bryson
Journal: JAMA (1978)

PLANTS are a well-known source for many of the atropine-like alkaloids. Mushrooms (<i>Amanita muscaria</i>), bittersweet (<i>Solanum dulcamara</i>), jimson weed (<i>Datura stramonium</i>), potato leaves, and the deadly nightshade (<i>Atropa belladonna</i>) are just a few of the plants that contain these alkaloids. Ingestions of various members of this group have led to signs of anticholinergic toxicity. Although other herbal preparations are known to cause psychoactive effects, to our knowledge there have been no previous reports of the common burdock plant containing any of these toxic alkaloids or causing any symptoms.<sup>1</sup>We present a case report of burdock root tea ingestion. <h3>Report of a Case</h3> A 26-year-old woman came to the emergency department complaining of blurred vision, inability to void, a dry mouth, and a history of bizarre behavior. She had previously purchased packaged burdock root tea from a local health food shop, an outlet of a national chain. She stated that
Lewis Test
Journal: CA A Cancer Journal for Clinicians (1970)

TestAfter careful study of the literature and other information available to it, the American Cancer Society does not have evidence that the Lewis Test is a proven method of diagnosing cancer in human beings.The following is a summary of infor mation on the Lewis Test in the American Cancer Society files: TestAccording to an undated brochure, dis tributed in 1969 by Lewis 3-D Test, Inc., and designated by Andrew J. Lewis, Pres ident, as giving factual information, the Lewis Test, also known as the 3-D Test and the Delayed Double Diffusion (3-D) Test, â€oe¿ utilizes a modified Ouchterlony technique with a reagent manufactured from horse plasma containing antibodies against human neoplasms.1Known posi tive and negative human sera are used as controls.The Test is an immuno-diffusion procedure which requires a specially pre pared agar with inoculating wells precut in a pattern prescribed by the developer,â€•
Systematic Analysis of G Protein-Coupled Receptor Gene Expression in Adrenocorticotropin-Independent Macronodular Adrenocortical Hyperplasia Identifies Novel Targets for Pharmacological Control of Adrenal Cushing’s Syndrome
Authors: Guillaume Assie, Estelle Louiset, Nathalie Sturm, Fernande Rénée-Corail, Lionel Groussin, Jerôme Bertherat, Michaël Thomas, Hervé Lefebvre, Jean-Jacques Feige, Eric Clauser, Olivier Chabre, Nadia Cherradi
Journal: Endocrine Reviews (2010)

Stimulation of cortisol secretion through abnormally expressed G protein-coupled receptors (GPCRs) is a frequent feature of ACTH-independent macronodular adrenal hyperplasia (AIMAH). This has opened a pharmacological strategy that targets GPCRs for the treatment of Cushing’s syndrome in AIMAH. However, only few drugs are available for the presently described GPCRs. The objective of the study was to identify new GPCR targets for the pharmacological treatment of adrenal Cushing’s syndrome. We designed a cDNA chip containing 865 nucleotidic sequences of GPCRs. mRNAs were extracted from three normal adrenals, 18 AIMAHs, four adrenals from Cushing’s disease patients, and 13 cortisol-secreting adenomas. A set of GPCR mRNAs that showed significantly higher or lower expression in AIMAH than in normal adrenal were studied by quantitative RT-PCR analysis. Analysis of protein expression and function were performed on selected GPCRs. The study was conducted at a tertiary care center and basic research laboratories. The ACTH MC2 receptor showed a low expression in 15 of 18 AIMAHs samples, whereas several previously undescribed GPCR genes were found highly expressed in a subset of AIMAH, such as the receptors for motilin (three of 18 AIMAHs), γ-aminobutyric acid (five of 18 AIMAHs), and the α2A adrenergic receptor (ADRA2A; 13 of 18 AIMAHs) on which we focused our attention. Western blot and immunochemistry analyses showed expression of ADRA2A protein in AIMAH but not in normal adrenal cortex. The ADRA2A agonist clonidine enhanced both basal and stimulated cortisol production. Clonidine-induced increase in basal cortisol levels was blocked by the ADRA2A antagonist yohimbine. ADRA2A is a potential target for pharmacological treatment of Cushing’s syndrome linked to AIMAH.
ECFMG Examinations
Authors: Aims C. McGuinness
Journal: JAMA (1970)

Henry R. Mason, in studies conducted in the fall of 1969, reported in a written communication (Feb 6, 1970) that an estimated 2,843 US citizens (including approximately 500 Puerto Ricans) were attending medical school in 16 medical schools visited by him in Belgium, Italy, Mexico, Spain, and Switzerland. While the largest numbers of American citizens attending medical schools abroad attend those visited by Mason, a lesser number of Americans attend medical schools in other European countries. Although precise figures are not presently available, the total number of Americans studying medicine abroad may be in the range of 3,500 to 4,000. Beginning in 1969, the Educational Council for Foreign Medical Graduates has published in the Annual State Board Number of the<i>Journal of the American Medical Association</i>(now known as the Medical Licensure Number)<sup>1,2</sup>a tabulation showing the number of candidates from each medical school who took the examinations of
Abstract 4799: Epigenetic antagonism between Polycomb and SWI/SNF complexes during oncogenic transformation
Authors: Boris G. Wilson, Xiaohua Shen, Elizabeth S. McKenna, Xi Wang, Yoon-Jae Cho, Edward C. Koellhoffer, Phuong T.L. Nguyen, Scott L. Pomeroy, Stuart H. Orkin, Charles W.M. Roberts
Journal: Cancer Research (2010)

Abstract Epigenetic alterations serve critical roles in cell fate decisions and have increasingly been implicated in cancer formation. The Polycomb Group (PcG) protein EZH2 mediates epigenetic gene silencing, displays pro-oncogenic properties in cell lines and is frequently overexpressed in cancer. Conversely, loss of function mutations in the tumor suppressor gene SNF5, a core subunit of the SWI/SNF chromatin remodeling complex, occur in several types of aggressive human cancers. Intriguingly, analysis of homeotic mutants in Drosophila suggests that PcG and SWI/SNF can serve antagonistic roles in the epigenetic control of gene expression. Here we have investigated functional relationships between these epigenetic regulators in oncogenic transformation by examining the role of EZH2 in tumors driven by SNF5 loss. Notably, SNF5-mutant tumors, despite being highly aggressive, are diploid and genomically stable, making them an ideal model with which to elucidate epigenetic drivers of oncogenesis. We show that targeted inactivation of Snf5 leads to increased expression of Ezh2 and that EZH2 is upregulated in SNF5- deficient cancers. A key mechanism by which SNF5 loss promotes oncogenesis is via downregulation of the p16INK4a tumor suppressor. We show that inactivation of Ezh2 restores normal levels of p16INK4a to Snf5-deficient fibroblasts. We further show that reducing the levels of EZH2 in a human SNF5-deficient tumor cell line leads to increased levels of p16INK4a accompanied by slowed proliferation and cellular senescence. Most importantly, using conditional mouse models, we show that inactivation of EZH2 completely blocks tumor formation driven by SNF5 loss. Our results demonstrate an essential role for Ezh2 in oncogenic transformation in vivo and show that perturbing the epigenetic balance of gene expression mediated by EZH2 silencing and SWI/SNF activation can have a profound effect on tumor formation. Further, we establish that targeted inhibition of EZH2 in vivo can have potent anti-cancer effects. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4799.
Immediate vs Delayed Catheterization and Angioplasty Following Thrombolytic Therapy for Acute Myocardial Infarction
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Leads from the MMWR. State legislation concerning use of safety belts--United States, 1985
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Use of ethacrynic acid in mannitol-resistant oliguric renal failure
Authors: R. G. Auger
Journal: JAMA (1968)

Two patients had oliguric acute renal failure in which there was no response to intravenously administered mannitol. In both cases, diuresis resulted after simultaneous administration of mannitol and ethacrynic acid intravenously. Dialysis treatment was unnecessary. The production of a greater volume of urine decreases the tendency toward excess total body water and sodium, and extracellular potassium, and simplifies management. A therapeutic trial with both these drugs may be indicated in the oliguric phase of acute renal failure.
"WHOMEVER"
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lumbalanästhesie in der Geburtshilfe und Gynäkologie mit besonderer Berücksichtigung der Biochemie des Liquors und der Blutliquorschranke
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Uncharted Seas
Authors: Lawrence G. Raisz
Journal: JAMA (1991)

How remarkable and characteristic it is of Fuller Albright that he bequeathed us a hidden treasure! This small, enchanting book was written to convey to laypersons as well as fellow clinical investigators some of the successes, as well as the disappointments, of clinical research, the discipline that we identify with Fuller Albright. His theme is the story of hyperparathyroidism, its cause, consequences, and cure. In telling this story, he also presents brief but insightful comments on the experimental method and the origins of endocrinology. For those of us who had the privilege of being students of Fuller Albright, this volume brings back some of the joy that we experienced long ago in his teaching. This book has many heroes. The pathologist Jacob Erdheim, with whom Albright studied, and other pioneer investigators who contributed to our understanding of the parathyroid glands are lovingly characterized. There is one unusual hero, the American
Estrogens and Menopause
Authors: Carol M. Proudfit
Journal: JAMA (1976)

RECENT reports suggest that the administration of estrogens to postmenopausal women is associated with an increased risk of acquiring endometrial cancer. The problem was identified in retrospective studies in which postmenopausal patients with endometrial cancer were compared to matched controls with respect to their history of estrogen therapy. Ziel and Finkle<sup>1</sup>compared 94 endometrial cancer patients with 188 controls from the same health plan who were matched on the basis of age, area of residence, and length of time in the health plan. The estimated risk of acquiring endometrial cancer was 7.6 times higher for women who were treated with estrogens, and the risk increased with the length of time on the medication. The estimated risk increased from 5.6 times for 1 to 4.9 years of use to 13.9 times for seven or more years of use. Smith et al<sup>2</sup>compared women with endometrial cancer to women with
A randomized, multicenter trial of epirubicin, oxaliplatin, and capecitabine (EOC) plus panitumumab in advanced esophagogastric cancer (REAL3).
Authors: Tom Samuel Waddell, Ian Chau, Yolanda Barbachano, David Gonzalez de Castro, Andrew Wotherspoon, Claire Saffery, Gary William Middleton, Jonathan Wadsley, David Raymond Ferry, Wasat Mansoor, Tom David Lewis Crosby, Fareeda Y Coxon, David Smith, Justin S. Waters, Timothy Iveson, Stephen Falk, Sarah Slater, Alicia Frances Clare Okines, David Cunningham
Journal: Journal of Clinical Oncology (2012)

LBA4000 The full, final text of this abstract will be available at abstract.asco.org at 12:01 AM (EDT) on Saturday, June 2, 2012, and in the Annual Meeting Proceedings online supplement to the June 20, 2012, issue of Journal of Clinical Oncology. Onsite at the Meeting, this abstract will be printed in the Saturday edition of ASCO Daily News.
Colonoscopy
Authors: S. P. Misra
Journal: Endoscopy (2004)

A large number of abstracts dealing with colonoscopy were presented at the Digestive Disease Week meeting held in New Orleans in 2004. Many were concerned with technological innovations in colonoscopy. Others topics dealt with included the efficacy, safety, and tolerability of various colon-cleansing agents; miss rates for colon cancer during routine and surveillance colonoscopy; virtual colonoscopy; methods of reducing colonic motility during colonoscopy; chromoscopy; and the usefulness of terminal ileal intubation during colonoscopy. A host of abstracts dealing with miscellaneous other topics were also presented; this review focuses only on what appeared to the author to be the most relevant presentations.
Peripheral Arterial Surgery
Authors: R. Clement Darling
Journal: New England Journal of Medicine (1969)

APPROXIMATELY 1200 articles pertaining to the surgery of peripheral vessels have been published since the last progress report six years ago.1 In addition, a number of textbooks have appeared during this time, and although none are completely satisfactory, two are worthwhile to the general reader2 , 3 and another clearly emphasizes the technical aspects of vascular surgery.4 This review is an analysis of progress rather than a comprehensive report of the literature. The bibliography is limited by editorial restraint and not by the lack of recognition of other significant contributions in this field. Because of my own interests, however, I have chosen . . .
Outbreak of Influenza A Infection Among Travelers— Alaska and the Yukon Territory, May-June 1999
Journal: JAMA (1999)

On June 18, 1999, CDC and Health Canada received reports from public health authorities in Alaska and the Yukon Territory about clusters of febrile respiratory illness and associated pneumonia among travelers and tourism workers. This report presents information about the outbreak. Laboratory evidence, including rapid influenza A antigen-detection tests and viral cultures from respiratory specimens, has implicated influenza A virus as the cause of illness.