tbuckley/cabot-search huggingface dataset:
Circulating tumor cell (CTC) enumeration in patients (pts) with metastatic genitourinary (mGU) tumors treated in a phase I study of cabozantinib and nivolumab (CaboNivo) +/- ipilimumab (CaboNivoIpi).
Authors: Zishuo Hu, Amir Mortazavi, Sumanta K. Pal, Primo Lara, Tina M. Mayer, Seth M Steinberg, Christian Mayfield, Katherine Graap, Marissa Mallek, Rene Costello, Carlos Diaz, Joseph Schonhoft, Yipeng Wang, Ryan Dittamore, Lincy Chu, Jane B Trepel, Donald P. Bottaro, Andrea B. Apolo
Journal: Journal of Clinical Oncology (2019)

379 Background: CTCs may serve as biomarkers for clinical outcomes in GU tumor pts. We examined the association between baseline CTC enumeration, change in CTC enumeration post treatment, progression-free-survival, overall survival and response to therapy with combination CaboNivo or CaboNivoIpi. Methods: 128 samples from 52 pts with mGU tumors treated with CaboNivo (38 pts) or CaboNivoIpi (14 pts) were drawn at baseline, cycle (C) 2 Day (D) 1, and C3D1 and processed with Epic Sciences platform. CTCs were defined as cytokeratin (CK)+, CD45-, distinct morphology, intact nucleus. PD-L1 expression was assessed. Results: From 07/20/2016-09/01/2018, 52 pts were treated for metastatic [urothelial carcinoma (UC) N = 33; UC plasmacytoid N = 1; clear cell renal cell carcinoma N = 4; bladder adenocarcinoma (BAC) N = 8; bladder squamous cell carcinoma N = 2; bladder small cell carcinoma N = 2; renal medullary carcinoma N = 2]. Median age was 61.5 years (range 20-82); 35 (67%) were male; N = 37(71%) had visceral involvement, N = 15(29%) had liver involvement, N = 11(21%) had bone involvement. CTCs were found in the peripheral blood of 39 (75%) pts, 1 pt (BAC) had PDL1+ CTCs at baseline. Median CTC/mL at C1D1, C2D1, C3D1, were 0.5 (0-357.1), 0.4 (0-71.8), and 0.75 (0-18), respectively. Median (lower and upper quartile) CTCs in pts with complete or partial responses (responders) vs stable or progressive disease (non-responders) were: 0.0 (0 to 5.40) vs 0.7 (0 to 2.5) at baseline; -0.35 (-3.65 to 0) vs 0 (-2 to 1.7) change from baseline to C2D1; and 0 (-5.4 to 0.5) vs 0 (-0.9 to 0.65) change from baseline to C3D1 (all p &gt; 0.15). CTC counts of &gt; 2 and &gt; 4 at C2D1 were potentially associated with shorter OS (p = 0.071 and p = 0.045 without adjustment for multiple cutoffs for evaluation). PFS results exhibited similar trends. Conclusions: CTC were detected in pts with mGU tumors treated with CaboNivo and CaboNivoIpi. CTC values were lower in responders than in non-responders. On treatment lower CTCs were associated with better clinical outcomes. Ongoing analyses with the CTCs include cell morphology and heterogeneity, single cell genomics, and T-cell populations.
Effervescent Suppositories
Authors: A. J. Martin, E. G. Beveridge
Journal: BMJ (1964)

automatically reported to the coroner for fur- ther investigation.In the unfortunate accident of choking, the subject dies because of his mental inability to react to the happening and also because of the inability of the witness to realize the cause of emergency.If the witness could think of choking fairly soon, a heavy blow with the fist, between the shoulderblades of the choking person leaned forward, may help dislodge the bolus impacting the larynx.A punch in time may save life.-Iam, etc..,
CONCERNING THE PRESENCE OF OXALIC ACID IN THE ORGANISM.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ORGANIZED MEDICAL DEFENSE.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Alzheimer's disease and corticotropin-releasing factor
Authors: L. W. Swanson
Journal: JAMA (1985)

Two subjects of broad interest to the basic and medical sciences have found a common ground in the accompanying article by Bissette and colleagues.<sup>1</sup>Alzheimer's disease is a common form of senile dementia with severe effects on cognition and affect. It has been studied intensely in recent years because a firm diagnosis can be made postmortem on the basis of neurofibrillary tangles and neuritic plaques, which are most common in the cerebral cortex, particularly in the hippocampal formation. Nothing is known with certainty about the etiology of Alzheimer's disease, although current interest has been sparked by the discovery that levels of the neurotransmitter acetylcholine are severely depleted in the hippocampus and other parts of the cerebral cortex in patients with the disorder.<sup>2</sup>This finding was of particular interest in view of evidence that the hippocampus plays a critical role in short-term memory, and the more permanent consolidation of
Sedation With Dexmedetomidine vs Lorazepam in Mechanically Ventilated Patients
Authors: Jeffrey F. Barletta
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
About Children.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Deficiencies in the English Medical Vocabulary
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Narcotics and Medical Practice
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
House Call
Authors: Audrey Young
Journal: Annals of Internal Medicine (2005)

On Being a Doctor1 February 2005House CallAudrey Young, MDAudrey Young, MDFrom Harborview Medical Center, Seattle, WA 98104.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-142-3-200502010-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail An 82-year-old retired nurse named Helen couldn't walk this morning. Her leg buckled when she stood and wouldn't snap back in like before. She shuffled from chair to exam table on the good leg and howled when I leaned on her shin. I could feel tibia scraping femur. I was a recent-mint city hospitalist filling in for a vacationing general internist in remote Montana, and to me Helen's story meant a knee brace, ibuprofen, and a next-day appointment with the local orthopedist. The twist was that Helen lived alone in a third-floor apartment. I pictured a dismal little room with ... Author, Article, and Disclosure InformationAffiliations: From Harborview Medical Center, Seattle, WA 98104.Current Author Address: Audrey Young, MD, Harborview Medical Center, 325 Ninth Avenue, Box 359780, Seattle, WA 98104; e-mail, [email protected]washington.edu. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byVNA HouseCalls of Greater Cleveland, Ohio: Development and Pilot Evaluation of a Program for High-Risk Older Adults Offering Primary Medical Care in the Home 1 February 2005Volume 142, Issue 3Page: 222-223KeywordsHospitalistsInpatientsKneesNursesSmellSurgeonsSurgeryTelemedicineTriageWheelchairs ePublished: 1 February 2005 Issue Published: 1 February 2005 Copyright & PermissionsCopyright © 2005 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Acidic Microenvironment Up-Regulates Exosomal miR-21 and miR-10b in Early-Stage Hepatocellular Carcinoma to Promote Cancer Cell Proliferation and Metastasis: Erratum
Authors: Xiao-Peng Tian, Chen-Yuan Wang, Xiao-Han Jin, Mei Li, Feng-Wei Wang, Wei-Juan Huang, Jing-Ping Yun, Rui-Hua Xu, Qing-Qing Cai, Dan Xie
Journal: Theranostics (2021)
Reply
Authors: F Parente, M Lazzaroni, G B. Porro
Journal: Gut (1993)

<h3>Abstract</h3> Lymphoblastoid Cell Lines (LCLs) are generated by transforming primary B cells with Epstein-Barr Virus (EBV) and are used extensively as model systems in viral oncology, immunology, and human genetics research. In this study, we characterized single-cell transcriptomic profiles of five LCLs and present a simple discrete-time simulation to explore the influence of stochasticity on LCL clonal evolution. Single-cell RNA sequencing revealed substantial phenotypic heterogeneity within and across LCLs with respect to immunoglobulin isotype; virus-modulated host pathways involved in survival, proliferation, and differentiation; viral replication state; and oxidative stress. This heterogeneity is likely attributable to intrinsic variance in primary B cells and host-pathogen dynamics. Stochastic simulations demonstrate that initial primary cell heterogeneity, random sampling, time in culture, and even mild differences in phenotype-specific fitness can contribute substantially to dynamic diversity in populations of nominally clonal cells.
Mental Health
Authors: A. V. Neale
Journal: BMJ (1960)

<h3>BACKGROUND AND PURPOSE:</h3> Increased CSF stroke volume through the cerebral aqueduct has been proposed as a possible indicator of positive surgical outcome in patients with idiopathic normal pressure hydrocephalus; however, consensus is lacking. In this prospective study, we aimed to compare CSF flow parameters in patients with idiopathic normal pressure hydrocephalus with those in healthy controls and change after shunt surgery and to investigate whether any parameter could predict surgical outcome. <h3>MATERIALS AND METHODS:</h3> Twenty-one patients with idiopathic normal pressure hydrocephalus and 21 age- and sex-matched healthy controls were prospectively included and examined clinically and with MR imaging of the brain. Eighteen patients were treated with shunt implantation and were re-examined clinically and with MR imaging the day before the operation and 3 months postoperatively. All MR imaging scans included a phase-contrast sequence. <h3>RESULTS:</h3> The median aqueductal CSF stroke volume was significantly larger in patients compared with healthy controls (103.5 μL; interquartile range, 69.8–142.8 μL) compared with 62.5 μL (interquartile range, 58.3–73.8 μL; <i>P</i> &lt; .01) and was significantly reduced 3 months after shunt surgery from 94.8 μL (interquartile range, 81–241 μL) to 88 μL (interquartile range, 51.8–173.3 μL; <i>P</i> &lt; .05). Net flow in the caudocranial direction (retrograde) was present in 11/21 patients and in 10/21 controls. Peak flow and net flow did not differ between patients and controls. There were no correlations between any CSF flow parameters and surgical outcomes. <h3>CONCLUSIONS:</h3> Aqueductal CSF stroke volume was increased in patients with idiopathic normal pressure hydrocephalus and decreased after shunt surgery, whereas retrograde aqueductal net flow did not seem to be specific for patients with idiopathic normal pressure hydrocephalus. On the basis of the results, the usefulness of CSF flow parameters to predict outcome after shunt surgery seem to be limited.
Crack Smiles
Authors: Stephen G. Rothstein
Journal: JAMA (1991)

<h3>To the Editor.—</h3> A new form of facial trauma is occurring among the drug addict population in New York City. The Department of Otolaryngology at the New York (NY) University Medical Center has treated six patients over the past 6 months with facial lacerations involving the facial nerve and, less frequently, the parotid duct. These injuries were deliberately inflicted by drug pushers or other addicts in order to create a scar to serve as a reminder to others of the punishment that would occur for a "bad deal." The lacerations are linear and clean, inflicted with a razor blade or knife. The injuries extend from the tragus to the oral commissure and are called "half-smile" (if unilateral) or "smile" scars (if bilateral). On the street, they are also known as "life marks." The facial nerve is identified proximal and distal to the injury and reanastomosis is performed with a fine
Tobacco hearings: penetrating the smoke screen
Authors: C. Marwick
Journal: JAMA (1994)

WOULD-BE DIEHARD smokers are facing a new challenge—federal regulation of tobacco products. Concern about the hazards to health of smoking has led in recent years to a ban against the practice in most public buildings and nearly all parts of government and many private office buildings, not to mention the sequestration of smokers in restaurants. Congress is considering a bill that would ban smoking in all public buildings. Smoking, in short, has become an antisocial habit. Now there are moves in Congress that may result in regulating tobacco to reduce its addictive potential. At the same time, no outright prohibition against smoking is contemplated, and Congress is unlikely to pass any new federal legislation regulating tobacco products in the current session. But the opening salvos have been fired. The issue of regulating tobacco has been put on the table and is not going to disappear in a cloud of smoke.
CANCER OF THE RECTUM
Authors: W. S. Handley
Journal: BMJ (1910)

Routh deplore the falling birth-rate tlhougll it is causing no fall in the population's rate of increase?Even in France the death-rate declines with the birth-rate; moreover, her recently published records for the first six months of 1913 show that there were 8,000 more births than during the same period of the previous year, but that there were 12,000 more deaths-in other words, that a rise of her birth-rate was accompanied by a still greater rise of the death-rate.Dr. Routh says that "every method of artificial prevention of conception is harmful in both its physical and its moral effect."Is there any scientific evidence to support such a sweeping statement ?
Abstract LB-158: Tribal sovereignty and approval for research in Native American communities
Authors: Carol Goldtooth, Nicolette Teufel-Shone, Francine C. Gachupin
Journal: Cancer Research (2019)

Abstract Background: Native Americans (NAs) experience worse outcomes and lower chances of cancer survival than other racial groups in the US. Despite improvements in cancer screening techniques and major developments in cancer treatment in past decades, NA communities do not benefit equally from these advances. Furthermore, relatively little of the advancements in cancer research addresses the specific vulnerabilities and strengths in these communities. Community-based research with NA populations including cancer research is influenced by the ways tribes approach and approve research. Tribe specific approval processes are assertions of sovereignty and of tribal right to govern and manage activities on tribal lands. Researchers often interpret required tribal approval for research, presentation and publication as punitive and a barrier to timely research and dissemination. Objective: An overview of the evolution and range of tribal research approval processes can address the cultural discordance faced by researchers and NA communities and supports researchers’ effort to gain approval to conduct much needed community-based cancer research. Methods: This presentation outlines the diversity of tribal research processes, including established Tribal Institutional Review Boards (IRBs), Tribal Advisory boards, Tribal Council approval, and Indian Health Service (IHS) IRB approval. Guidance will be provided to inform the development of research study designs that meet the needs of the community and have the potential to guide cancer treatment practice and cancer prevention education. In addition, this review will demonstrate that respecting the distinct characteristics of separate tribes relative to experience with research and leadership oversight of research activities is important to obviate homogenization of NA communities and enhance the relevance of research. Conclusion: Research design, implementation and interpretation are strengthened by tribal research approval processes by requiring researchers to justify their research methods, hypotheses and expected benefits to the community and NA populations. Concurrently, adhering to procedures, protocols and requirements established by tribal councils supports tribal sovereignty in action. Citation Format: Carol Goldtooth, Nicolette Teufel-Shone, Francine C. Gachupin. Tribal sovereignty and approval for research in Native American communities [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr LB-158.
Varicella-zoster infections in pregnancy
Authors: P. A. Brunell
Journal: JAMA (1967)

Ten pregnant women with varicella and one pregnant woman with herpes zoster were studied. Only one of these women had a complicated course characterized by nephritis and hepatitis and the birth of a stillborn infant. One other woman who had vaginal bleeding for a month prior to the onset of varicella aborted two weeks after recovery from varicella. Seven women who were observed to term delivered normal, full-term infants. Large doses of γ-globulin which were given to four infants whose mothers had varicella within a week prior to delivery failed to produce a detectable rise in serum varicella-zoster (V-Z) antibodies. Three of these infants who were born without V-Z serum antibody got neonatal varicella. All recovered uneventfully.