tbuckley/cabot-search huggingface dataset:
Über das Verhalten von Stechmücken besonders von Anopheles maculipennis bei verschiedenen Temperaturen und Luftfeuchtigkeiten.
Journal: JAMA (1933)

Experiments with Culex pipiens, Theobaldia annulata, Aedes aegypti and Anopheles maculipennis were conducted to determine the effects of combinations of various temperatures and humidities on their length of life, their biting habits, their hibernation activities and the finding of places of shelter. The morphologic and bionomic differences between the varieties messeae and atroparvus of Anopheles maculipennis are recapitulated and discussed in connection with their malaria-carrying ability. It is shown that the distributions of these two varieties between houses and stables may be exactly opposite in different climates or may differ markedly in different regions, owing to differences in the prevalence of construction of dwellings and stables. The influences, favorable and unfavorable, of temperatures and humidities on the longevity or mortality of various species and races of mosquitoes are shown to be the chief determining factors in their different distributions. The authors attack the problem of anophelism without malaria in a
Portal Hypertension
Authors: Norman B. Roberg
Journal: JAMA (1968)

Monographs for students and practitioners should be concise, self-sufficient, authoritative and well-illustrated. In this monograph, the format, printing, and diagrams are excellent, but the clarity is marred by excessive, spotty, and badly written references to the literature, eg, "The existence of a hepatic blood flow intrinsic regulatory mechanism dependent on the arterial blood flow has been postulated.<sup>74</sup>" Excellent chapters, well-illustrated, take up anatomy, collateral circulation, the management of acute bleeding, and surgical techniques. The chapter on physiology is a static, uncritical compilation from the literature. Although the Fick principle is described in textbook detail, oxygen contents are given in percentage-saturations or volumes percent without explaining their relationship or giving normal values. The inadequate correlation of systemic and portal circulatory changes, and the compilations of average and mean values obtained by various investigators, confuse rather than clarify existing knowledge. This section would be improved by a simpler description and by
Effects of smoking intervention and the use of an inhaled anticholinergic bronchodilator on the rate of decline of FEV1. The Lung Health Study
Authors: N. R. Anthonisen
Journal: JAMA (1994)

<h3>Objective.</h3> —To determine whether a program incorporating smoking intervention and use of an inhaled bronchodilator can slow the rate of decline in forced expiratory volume in 1 second (FEV<sub>1</sub>) in smokers aged 35 to 60 years who have mild obstructive pulmonary disease. <h3>Design.</h3> —Randomized clinical trial. Participants randomized with equal probability to one of the following groups: (1) smoking intervention plus bronchodilator, (2) smoking intervention plus placebo, or (3) no intervention. <h3>Setting.</h3> —Ten clinical centers in the United States and Canada. <h3>Participants.</h3> —A total of 5887 male and female smokers, aged 35 to 60 years, with spirometric signs of early chronic obstructive pulmonary disease. <h3>Interventions.</h3> —Smoking intervention: intensive 12-session smoking cessation program combining behavior modification and use of nicotine gum, with continuing 5-year maintenance program to minimize relapse. Bronchodilator: ipratropium bromide prescribed three times daily (two puffs per time) from a metered-dose inhaler. <h3>Main Outcome Measures.</h3> —Rate of change and cumulative change in FEV<sub>1</sub>over a 5-year period. <h3>Results.</h3> —Participants in the two smoking intervention groups showed significantly smaller declines in FEV<sub>1</sub>than did those in the control group. Most of this difference occurred during the first year following entry into the study and was attributable to smoking cessation, with those who achieved sustained smoking cessation experiencing the largest benefit. The small noncumulative benefit associated with use of the active bronchodilator vanished after the bronchodilator was discontinued at the end of the study. <h3>Conclusions.</h3> —An aggressive smoking intervention program significantly reduces the age-related decline in FEV<sub>1</sub>in middle-aged smokers with mild airways obstruction. Use of an inhaled anticholinergic bronchodilator results in a relatively small improvement in FEV<sub>1</sub>that appears to be reversed after the drug is discontinued. Use of the bronchodilator did not influence the long-term decline of FEV<sub>1</sub>. (<i>JAMA</i>. 1994;272:1497-1505)
In Reply:
Authors: Harold J. Burstein
Journal: Journal of Clinical Oncology (2006)

was also described by Burstein et al. 3 In these situations, a potentially safer and simpler intervention after a high day 1 ANC (eg, Ͼ 25,000/mm 3 ) might be to simply switch from pegfilgrastim support to just a few doses of filgrastim, as five or fewer doses of filgrastim might be enough to support adjuvant chemotherapy. 10 Prospective studies are warranted.CSFs are clearly an advance for many patients, though the hyperleukocytosis event observed in Patient 1 raises concerns about the potential overutilization of pegfilgrastim in some patients.They are among the top-selling oncology drugs worldwide, 11 and the United States Food and Drug Administration recently expanded the pegfilgrastim label to include the primary prophylaxis of moderately myelosuppressive regimens (febrile neutropenia risk Ͻ 20%). 12,13 These case reports should serve as a reminder for the need for continuing long-term surveillance in view of the rapid expansion of the use of CSFs in otherwise healthy cancer patients receiving adjuvant chemotherapy.
Abstract 2565: Type I interferons enhance chemosensitivity of breast cancer by inhibiting DNA repair
Authors: Na-Lee Ka, Ga Young Lim, Mi-Ock Lee
Journal: Cancer Research (2019)

Abstract Type I interferons (IFNs) are known to have antineoplastic effects against several tumors by stimulating anticancer immune response. In this study, we identified a novel function of type I IFNs in DNA repair, which enhanced chemosensitivity in breast cancer cells. We investigated that IFNα and IFNβ inhibited both non-homologous recombination and homologous recombination double strand breaks repair. Moreover, IFNs accelerated the release of DNA into the cytoplasm in response to DNA damaging agent, doxorubicin. In agreement, IFNs synergistically activated DNA damage-induced STING pathway and increased the production of chemokines, CCL5 and CXCL11. In agreement, IFNβ greatly increased the sensitivity of cells to doxorubicin-induced suppression of cell survival. This sensitizing effect of IFNβ was also supported by in vivo xenograft experiments. Thus, combination therapy with chemotherapeutic agents and IFNs may be effective against breast cancer, particularly in patients with defective in DNA damage response pathways. The downstream effectors that modulate the effect of IFNs should be investigated as predictive biomarker in the treatment of breast cancer. Citation Format: Na-Lee Ka, Ga Young Lim, Mi-Ock Lee. Type I interferons enhance chemosensitivity of breast cancer by inhibiting DNA repair [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2565.
Ileostomy Associations: "For Those Who Need"
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Albert Lasker Medical Awards. The family of protein kinase C for signal transduction
Authors: Y. Nishizuka
Journal: JAMA (1989)

Protein kinase C, an enzyme that is activated by diacylglycerol resulting from the receptor-mediated hydrolysis of inositol phospholipids, relays information of a variety of extracellular signals across the cell membrane to regulate many intracellular processes. Since this enzyme also serves as a major receptor for phorbol esters, a class of tumor promoters, it has attracted great attention from biologists interested in the mechanism of signal transduction and carcinogenesis. Recent analysis has revealed that protein kinase C is a large family of proteins, with the multiple subspecies that possess subtle individual enzymological characteristics. Biochemical and immunohistochemical studies indicate that the protein kinase C subspecies may be differently distributed in particular cell types and with limited intracellular locations. Presumably, each member of the family plays discrete roles in the processing of various physiological and pathological responses to external signals, such as in the modulation of membrane functions and the activation of gene transcription.
Flow cytometric vs morphologic assessment of remission in childhood acute lymphoblastic leukemia: A report from the Children’s Oncology Group (COG)
Authors: S Gupta, M Devidas, M L Loh, E A Raetz, S Chen, C Wang, P Brown, A J Carroll, N A Heerema, J M Gastier-Foster, K P Dunsmore, E C Larsen, K W Maloney, L A Mattano, S S Winter, N J Winick, W L Carroll, S P Hunger, M Borowitz, B L Wood
Journal: Leukemia (2017)
Hoofbeats
Authors: Donna Beales
Journal: Annals of Internal Medicine (2008)

On Being a Patient15 January 2008HoofbeatsDonna Beales, MLISDonna Beales, MLISFrom Lowell General Hospital, Lowell, MA 01850.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-148-2-200801150-00013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail I grew up infatuated with horses. Like many little girls, especially small, wall-eyed, chubby ones such as myself, I was drawn to their majestic size, power, and beauty. For years I pretended to be a horse. I was never a zebra. Zebras were ungainly creatures with no romantic appeal, short and squat, like me.When I grew older, I took riding lessons. We rode English-style, “heads up, heels down, back straight!” I could never quite comply. I tired quickly, back aching with the effort of trying to sit up straight for long periods of time with scoliosis, legs trembling with ... Author, Article, and Disclosure InformationAffiliations: From Lowell General Hospital, Lowell, MA 01850.Corresponding Author: Donna Beales, MLIS, Lowell General Hospital, 295 Varnum Avenue, Medical Library, Lowell, MA 01850; e-mail, [email protected]org. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byLuftnot im DampfbadOn the clinical encounter with 'zebras' – the science and art of rare diseases 15 January 2008Volume 148, Issue 2Page: 164-165KeywordsCoughingLibrariesMemoryOtorhinolaryngologyTurner syndromeUltrasound imagingUterusVisionX chromosomes ePublished: 15 January 2008 Issue Published: 15 January 2008 Copyright & PermissionsCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
MicroRNA-182 drives metastasis of primary sarcomas by targeting multiple genes
Authors: Mohit Sachdeva, Jeffrey K. Mito, Chang-Lung Lee, Minsi Zhang, Zhizhong Li, Rebecca D. Dodd, David Cason, Lixia Luo, Yan Ma, David Van Mater, Rebecca Gladdy, Dina C. Lev, Diana M. Cardona, David G. Kirsch
Journal: Journal of Clinical Investigation (2016)

In the process of transferring the miR-182-flox and LSL-miR-182 mice to the Jackson Laboratory, the authors realized that the description of how the LSL-miR-182 mice were generated in the manuscript contained an error.Although the miR-182-flox mice were generated by crossing the mice to a flpO deleter strain to delete the Neo cassette, as was stated in the Methods section, the R26-LSL-miR-182 mice were not crossed to a deleter strain.Instead, the R26-LSL-miR-182 mice that were utilized in this work retained the Neo cassette.Two corrected sentences for the Methods section are below.Chimeric males were mated to WT C57BL/6 females to generate heterozygotes.These mice were subsequently crossed to a flpO deleter strain to excise the frt-Neo-frt cassette to generate miR-182-flox mice.
"THE FUTURE INDEPENDENCE AND PROGRESS OF AMERICAN MEDICINE IN THE AGE OF CHEMISTRY"
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
EAT AND STAY THIN
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
On a New Method of Performing Plastic Operations
Authors: J. R. Wolfe
Journal: BMJ (1881)

<h3>Abstract</h3> The current trend for implantable Brain Machine Interfaces (BMIs) is to increase the channel count, towards next generation devices that improve on information transfer rate. This however increases the raw data bandwidth for wired or wireless systems that ultimately impacts the power budget (and thermal dissipation). On-implant feature extraction and/or compression are therefore becoming essential to reduce the data rate, however the processing power is of concern. One common feature extraction technique for intracortical BMIs is spike detection. In this work, we have empirically compared the performance, resource utilization, and power consumption of three hardware efficient spike emphasizers, Non-linear Energy Operator (NEO), Amplitude Slope Operator (ASO) and Energy of Derivative (ED), and two common statistical thresholding mechanisms (using mean or median). We also propose a novel median approximation to address the issue of the median operator not being hardware-efficient to implement. These have all been implemented and evaluated on reconfigurable hardware (FPGA) to estimate their hardware efficiency in an ultimate ASIC design. Our results suggest that ED with average thresholding provides the most hardware efficient (low power/resource) choice, while using median has the advantage of improved detection accuracy and higher robustness on threshold multiplier settings. This work is significant because it is the first to implement and compare the hardware and algorithm trade-offs that have to be made before translating the algorithms into hardware instances to design wireless implantable BMIs.
The Art of Anaesthesia.
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Turtle-associated salmonellosis in the United States. Effect of Public Health Action, 1970 to 1976
Authors: M. L. Cohen
Journal: JAMA (1980)

We examined the effect of state and federal legislative actions on the incidence of human salmonellosis associated with pet turtles. Using the Salmonella Surveillance System of the Center for Disease Control, we identified<i>Salmonella</i>serotypes that were and were not specifically turtle associated. From 1970 to 1976, there was a 77% reduction in frequency of turtle-associated serotypes and no consistent trend among non-turtle-associated serotypes. Decrease in frequency of turtle-associated serotypes correlated best with decrease in total production of pet turtles. Reduction in turtle-associated serotypes temporally correlated with an 18% reduction in frequency of salmonellosis in children, aged 1 to 9 years. Frequency of turtle-associated serotypes rapidly fell in states importing turtles, in contrast to states producing them. Continued although infrequent occurrence of salmonellosis in children with pet turtles counsels against relaxing legislation concerned with its control. (<i>JAMA</i>243:1247-1249, 1980)
Correction
Journal: BMJ (1953)

Absence of Axillary Hair in a Man Q.-An athlletic young inati of 18 sulffers conisiderable embarrassment when changinig with other men, as he has no axillary hair and a feminine distribution of his pubic hair.He does not need to shave.His genitalia are normnally developed, and he has heterosexual interests.What are the likely causes of this condition, and whlat treatment is advised ?A.-The usual cause of failure of growth of sexual hair is deficient secretion of testosterone by the interstitial tissue of the testes.On the other hand, it may sometimes be due to resistance of the hair follicles to the normal stimulation of testosterone.This latter cause is probable in the present case, since the patient's genitalia are normally developed.If this is so, there is no effective treatment.However, I suggest that a trial be made with testosterone propionate injected intramuscularly in doses of 50 mg.twice a week.Several months' treatment will be necessary.If injections prove to be inconvenient, methyl testosterone may be given by mouth in doses of 25 mg.daily.Barrier Creams for Oily Materials Q.-Whlat barrier creams are utsefutl againist oily mnaterials in intdustry ?A.-Various creams have been advocated as protection against oily materials in industry, but objective laboratory
TCT-479 Impact of Left Ventricular Outflow Tract (LVOT) Morphology and LVOT-Annular Mismatch on Paravalvular Leak and New Conduction Abnormalities after Transcatheter Aortic Valve Replacement: Concept of the “Non-Tubular Index” and LVOT Sealing Zone
Authors: Syed Zaid, Gilbert Tang, Samuel R. Schnittman, Hasan Ahmad, Ryan Kaple, Tanya Dutta, Angelica Poniros, Joanne Bennett, Cheng Feng, Martin Cohen, Steven Lansman
Journal: Journal of the American College of Cardiology (2017)
Council on Pharmacy and Chemistry
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pituitary tumours
Authors: S J Hurel, P Kendall-Taylor, P H Baylis
Journal: BMJ (1994)

decides whether a complaint should be dealt with by a formal procedure.As a result, general practitioners have faced time consuming and stressful investigations and hearings, even when the complaint concemed a trivial matter.Officers dealing with complaints in general practice have not been held accountable for deciding whether to go to a formal hearing in any particular case.
Low hepatitis B surface antigen at baseline and increased ALT levels during treatment predicts significant HBsAg decline in peginterferon alfa added to long-term nucleus(t)ice analogue. Results from two randomized controlled trials in 165 patients
Authors: Mina Farag, Hannah S.J. Choi, Scott Fung, Heng Chi, Margo J.H. van Campenhout, Seng Liem, Qing Xie, Milan Sonneveld, David Wong, Jordan Feld, Karel J. van Erpecum, Robert De Man, Bettina Hansen, Harry Janssen
Journal: Journal of Hepatology (2020)