Propranolol
Authors: JERROLD KRAM
Journal: Annals of Internal Medicine (1974)

Comments and Corrections1 February 1974PropranololJERROLD KRAM, M.D., HENRY R. BOURNE, M.D., KENNETH L. MELMON, M.D., HOWARD MAIBACH, M.D.JERROLD KRAM, M.D.Search for more papers by this author, HENRY R. BOURNE, M.D.Search for more papers by this author, KENNETH L. MELMON, M.D.Search for more papers by this author, HOWARD MAIBACH, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-80-2-282 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We would like to call attention to a potentially dangerous, adverse reaction to epinephrine when combined with propranolol: marked bradycardia and atrioventricular block. These drugs were administered as part of an investigation of the effects of adrenergic agents on cutaneous immediate hypersensitivity. The subject, a 22-year-old man in good health, gave informed consent to a protocol approved by the Committee on Human Experimentation of the University of California School of Medicine, San Francisco.Epinephrine was first administered alone at a rate of 17 µg/min intravenously, and produced a rise in blood pressure (arm cuff) from 110/80 mm...References1. DIENSTLGMEINERRAAS FRE: Veränderungen des Mechanokardiogramms und des Blutderuckes durch Adrenalin vorundnach Blockade adrenergischer B-rezeptoren. Klin Wochenschr 44(1) :41-44, 1966 CrossrefMedlineGoogle Scholar2. PARRASCHULTZ AR: Metabolic response to simultaneous infusion of epinephrine and propranolol in obese adolescents. Metabolism 18:497-508, 1969 CrossrefMedlineGoogle Scholar3. MORRELLI H: Propranolol. Ann Intern Med 78:913-917, 1973 LinkGoogle Scholar4. NIESSHAND AD: Hypertensive response to propranolol in a patient treated with methyldopa—a proposed mechanism, Clin Pharmacol Ther 14:823-826, 1973 CrossrefMedlineGoogle Scholar1. PODOLSKYLATTAVINA SC: Hyperosmolar non-ketotic diabetic coma: a complication of propranolol therapy. Metabolism 22:685-695, 1973 CrossrefMedlineGoogle Scholar1. LEVINE R: Mechanisms of insulin secretion. N Engl J Med 283:522-526, 1970 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Division of Clinical Pharmacology Departments of Medicine, Pharmacology, and Dermatology University of California Medical Center San Francisco, California PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHypertensionAdverse effects of epinephrine when given to patients taking propranolol (Inderal)Contraindications to vasoconstrictors in dentistry: Part IIISevere epinephrine-propanolol interactionInitial Therapy for Mild HypertensionInteraction of orally administered metoprolol, practolol and propranolol with isoprenaline in asthmaticsInfluence of metoprolol* and propranolol on hemodynamic effects induced by adrenaline and physical workPropranolol in orthostatic tachycardia 1 February 1974Volume 80, Issue 2Page: 282-283KeywordsAdverse reactionsBlood pressureBradycardiaDrugsEpinephrineHypersensitivity Issue Published: 1 February 1974 PDF downloadLoading ...