tbuckley/cabot-search huggingface dataset:
Medical education: the decade of massive change
Authors: L. S. King
Journal: JAMA (1984)

For 2,500 years medicine has had three mutually dependent aspects. First (and foremost) is practice. This, simply stated, means making sick people well and keeping well people from getting sick. It also included what the older physicians called hygiene and we call public health and preventive medicine. Second, we have science. I do not want to go into the meaning of this word but will refer only to the branches important for medicine—anatomy, physiology, pathology, chemistry, and the like. Third, we have education, the transmission of knowledge and skills to the young who will in turn become physicians. These three components act one on the other. Improvement in science brings about changes in practice, which in turn lead to needed readjustments in education. Better education can then result in better science and better practice. Better practice, along with its other advantages, opens more opportunities for improved science. The circular interactions
Nosocomial<i>Ralstonia pickettii</i>Colonization Associated With Intrinsically Contaminated Saline Solution—Los Angeles, California, 1998
Journal: JAMA (1998)

From February 24 through March 15, 1998, a total of 22 respiratory tract cultures from 13 patients at Childrens Hospital Los Angeles (CHLA), California, were culture-positive for Ralstonia pickettii. Because of this unusual cluster of colonization, on March 16 the Los Angeles County Department of Health Services initiated an investigation. This report summarizes the findings of the investigation, which resulted in a recall of sterile sodium chloride solution that was contaminated with R. pickettii.
Die Therapie der Placenta Praevia.
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sureté et efficacité du glycopyrrolate comme prémédication pour dissection sous muqueuse: une étude randomisée contre placebo en double aveugle
Journal: Endoscopy (2017)

Les sécrétions salivaires et bronchiques peuvent induire des hypoxémies transitoires et des épisodes de toux avec un risque de pneumopathie d’inhalation, notamment lors de procédures endoscopiques longues chez des patients non intubés.
First-trimester prenatal diagnostic method becoming available in U.S
Authors: V. Cowart
Journal: JAMA (1983)

A procedure for prenatal detection of genetic defects that is performed during the first trimester of pregnancy and yields preliminary results within 24 hours is now being offered to pregnant women known to be at risk for such fetal defects at Michael Reese Hospital and Medical Center in Chicago. The technique, called chorionic villi sampling, was developed in Europe and has been discussed at several conferences. Michael Reese is the first United States medical center to use it, although Yale University School of Medicine, New Haven, Conn, and Jefferson Medical College in Philadelphia are in the process of establishing programs. Six women with at-risk pregnancies have undergone the procedure at Michael Reese, according to Eugene Pergament, MD, PhD, director of medical genetics and associate director of the Dysfunctioning Child Center. One woman elected to have an abortion because trisomy 21 was detected. In one woman, the procedure was not successful.
Anticoagulant Control in Acute Myocardial Infarction
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
IMPROVEMENT IN COMPLEMENT FIXATION TEST FOR SYPHILIS
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Error in Results
Authors: Lindsay Nelson, Abpp-Cn Harvey, S Levin, Michael Mccrea, Sureyya Dikmen
Journal: JAMA Neurology (2019)

Donovan T. Maust, MD, MS; Erica Solway, PhD, MSW, MPH; Kenneth M. Langa, MD, PhD; Jeffrey T. Kullgren, MD, MS, MPH; Matthias Kirch, MS; Dianne C. Singer, MPH; Preeti Malani, MD, MSJ
Suppression of Insulin Production and Secretion by a Decretin Hormone
Authors: Ronald W. Alfa, Sangbin Park, Kathleen-Rose Skelly, Gregory Poffenberger, Nimit Jain, Xueying Gu, Lutz Kockel, Jing Wang, Yinghua Liu, Alvin C. Powers, Seung K. Kim
Journal: Cell Metabolism (2018)
Parallel 2: Bile Acids, Cholangiocyte Biology, and Experimental Cholestasis
Authors: Anuradha Rao, Astrid Kosters, Jamie Mells, Bradley Keller, Hong Yin, Sophia Banton, Shuzhao Li, Dean Jones, Hao Wu, Paul Dawson, Saul Karpen, Natalie Porat-Shliom, Lynn Vitale-Cross, Michal Jarnik, Christina Van Itallie, James Anderson, J Gutkind, Roberto Weigert, Irwin Arias
Journal: Hepatology (2015)

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the Western world.The mechanisms underlying NAFLD development and progression are not fully elucidated, and safe and effective NAFLD therapies are needed.Bile acids (BA) and their receptors have important roles in regulating whole body metabolism, including multiple hepatic targets coordinating lipid handling.We hypothesized that interruption of the enterohepatic BA circulation via a non-absorbable Apical Sodium-dependent BA Transporter (ASBT) inhibitor (ASBTi; SC435) would modify signaling in the gut-liver axis and diminish the development of NAFLD in High Fat Diet (HFD) fed mice.Methods: Male C57Bl/6 mice (n=12-16/group) were fed for 16 weeks with A) chow, B) HFD composed of 45% fat and 0.2% cholesterol, with 4% sucrose water (HFD), and C) HFD plus ASBTi (SC435; 60 ppm; HFD/ ASBTi).Body weight, food intake, glucose and insulin tolerance, liver histology, and liver lipids were measured.Molecular mechanisms were examined using RNASeq, metabolomics, and real-time PCR analyses.Results: In HFD versus HFD/ASBTi mice, administration of the ASBTi increased fecal BA excretion, and mRNA expression for colonic Ibabp (7.0±2.0 fold; p<0.05) as well as hepatic Cyp7a1 (2.4±1.0 fold; p<0.05) and Cyp8b1 (2.3±1.0 fold; p<0.05).Conversely, mRNA expression of the ileal FXR target gene Fgf15 was reduced 93±7% in HFD/ASBTi vs. HFD mice (p<0.05).Administration of the ASBTi did not affect body weight, but was associated with normalization of glucose and insulin tolerance, and significantly improved hepatic NAFLD Histologic Activity Score in HFD mice (4.8±1.0 to 2.8±0.9).Hepatic triglyceride (TG) and total cholesterol (CH) levels were significantly reduced in HFD/ ASBTi compared to HFD mice (mg/mg liver, TG: 93.4±61.8,versus 274.6±102.9;CH: 4.2±1.8,versus 8.7±2.6).Hepatic RNA levels of lipid synthesis genes Srebp1c, Pparα, Pparγ, Scd1, Fads1 and Fads2 all showed a 2-4 fold upregulation (p<0.05) by HFD, and were reduced to chow levels in HFD/ ASBTi mice.RNA levels of lipid droplet formation genes Cidea and Cidec were >50-fold induced by HFD (p<0.05) and significantly reduced by 70±30% and 86±10% with the ASBTi (p<0.05).Ontology and pathway analyses of RNAseq and metabolomics data confirmed changes in cholesterol and lipid metabolism pathways between HFD and HFD/ASBTi.Conclusion: In the HFD fed mouse model, inhibition of ASBT markedly improves hepatic steatosis and glucose handling, suggesting that a luminally-targeted therapy can improve both hepatic and whole body aspects of NAFLD.
Is the Vitamin D Receptor Found in Muscle?
Authors: Yongji Wang, Hector F. DeLuca
Journal: Endocrine Reviews (2011)

Abstract The active form of vitamin D, 1α,25-dihydroxyvitamin D3, is critical for the regulation of serum calcium and phosphorus levels that in turn support bone mineralization and neuromuscular activity. It is well known that vitamin D deficiency causes rachitic/osteomalacic myopathy and cardiac disorder and the provision of vitamin D can reverse the symptoms. However, the underlying mechanisms remain unclear. The question of whether the vitamin D receptor is found in muscle has been debated but not settled. We recently studied all available antibodies against the vitamin D receptor and found that most antibodies used detect proteins other than the vitamin D receptor, and therefore, the utility of these antibodies may generate the false-positive results. Using antibodies that do not detect proteins in tissues from vitamin D receptor null mice, we have developed a specific and sensitive immunohistochemical assay. The results from this investigation show that the vitamin D receptor is undetectable in skeletal, cardiac, and smooth muscle, suggesting that the function of vitamin D on muscle is either of an indirect nature or does not involve the known receptor.
Accidental profound hypothermia and barbiturate intoxication. A report of rapid "core" rewarming by peritoneal dialysis
Authors: R. F. Lash
Journal: JAMA (1967)

In a case of profound hypothermia, peritoneal dialysis was utilized with a dual purpose, removing barbiturate and rewarming the "core" in advance of the "shell." Recovery without any sequela occurred from a body temperature of 69.8 F (21 C).
Melanoma Information on the Internet: Often Incomplete—A Public Health Opportunity?
Authors: Christopher K. Bichakjian, Jennifer L. Schwartz, Timothy S. Wang, Janette M. Hall, Timothy M. Johnson, J. Sybil Biermann
Journal: Journal of Clinical Oncology (2002)

To assess the accuracy and completeness of information regarding melanoma on the Internet, retrieved by use of search engines.The first 30 uniform/universal resource locators (URLs) from each of eight search engines using the search term "melanoma" were retrieved for evaluation of accuracy and completeness using a 35-point checklist rating system instrument. Four reviewers independently rated each of 35 sites, and one reviewer rated all 74 assessable sites. Kappa statistics were used to evaluate interrater variability.A total of 74 assessable Web sites were evaluated. The remainder were inaccessible, link pages only, or duplicates. Thirty-five Web sites were each independently rated by four reviewers. The remaining 39 Web sites were each rated by one reviewer. The mean kappa statistic for all variables and all rater pairs for which a kappa could be calculated was 0.824, indicating excellent overall inter-rater reliability. The majority of Web sites failed to include complete information on general information, risk factors, diagnosis, treatment, prevention, and prognosis. Ten Web sites (14%) contained a total of 13 inaccuracies, most relatively minor.Medical information retrieved with the search term melanoma was likely to lack complete basic melanoma information and contained inaccuracies in 14% of sites. Health care providers can help patients by recommending comprehensive and accurate Web sites for patient review, by working to create accurate and thorough Web-based health information material, and by educating patients and the public about the variability in completeness and accuracy.
In This Issue
Journal: Circulation Research (2011)

␤-Myosin Heavy Chain in Smaller Myocytes (p 629)A classic hypertrophy-associated protein might in fact be antihypertrophic, say Lopez et al.The ␤-myosin heavy chain protein (␤-MyHC) is expressed in myocytes of the fetus, but after birth it is largely replaced by ␣-MyHC.During periods of cardiac hypertrophy, however, ␤-MyHC is once again activated.It was thought that this reactivation was part of the pathological process, but Lopez et al have now discovered that cardiac myocytes expressing ␤-MyHC do not undergo hypertrophy.The team analyzed between 10 000 and 20 000 cardiomyocytes from several hypertrophic mouse hearts and found that while in comparison with normal hearts, the number of cells expressing ␤-MyHC went up, these cells remained small.It was the cells that did not express ␤-MyHC that grew.All cells continued to express ␣-MyHC, so it appears to be the presence of ␤-MyHC rather than a switch from ␣-MyHC to ␤-MyHC that prevented cell growth.The team also found that ␤-MyHC expressing cells tended to be located in particular regions of the heart, including the papillary muscle, perivascular regions, and the base of the junction between left and right ventricles.Additional characterization of these ␤-MyHC expressing cells might help reveal how they avoid hypertrophy, and could offer clues for future antihypertrophic therapies.
MARRIAGE OF DEFECTIVES IN NEW YORK.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Dynamic Thyroid Study
Authors: Fuad S. Ashkar
Journal: JAMA (1971)

A method for a single-visit thyroid evaluation has been developed with use of sodium pertechnetate Tc 99m and the Anger camera to view the thyroid and cervical vessels. The technique records the first transit of this radioactive tracer through the thyroid and measures the carotid-thyroid transit time (CTTT). This index of function correlates well with other tests of thyroid function in over 200 patients studied. The CTTT is less than 2.5 seconds in patients with hyperthyroidism, more than 2.5 seconds in euthyroid patients, and prolonged and undertimed in those with hypothyroidism. The entire study including a scan is completed in less than five minutes after the patient has been injected with 10 millicuries of sodium pertechnetate Tc 99m. In an adult the radiation dose to the thyroid is reduced by a factor of 25 as compared to the radiation absorbed dose received from a thyroid scan with 50 microcuries of 131I.
Contents, Vol. 52, No. 1-3, 1989
Authors: Norman Sartorius, G. Reister, W. Tress, H. Schepank, R. Manz, B. Sollors-Mossler, T. Reitter, W. Tress, Tom Sensky, D.M. Rodrigues, J.F. Pontes, Marco Rigatelli, Massimo Marcon, Antonia Morritti, Isao Fukunishi, Isao Fukunishi, A.L. Rodrigues, Tom Sensky, M.C. Ventura, R. González, A. Alarcón, A. Morro, E. Llabres, Roger Zumbrunnen, Maria S. Kopp, Maximino Lozano, Carmen Carcedo, Rosario Artigao, David Huertas, Ana O'Neill of Tyrone, Carmelo Pelegrin, J.M. Maroto, Llnis Jordá, Sandra Conti, Gianni Savron, Giovanna Bartolucci, Silvana Grandi, Carlo Magelli, Franco Semprini, Francesco M. Saviotti, Giancarlo Trombini, Giovanni A. Fava, Bruno Magnani, Ayuso Mateos, Bayon Perez, Santo-Domingo Carrasco, D. Olivares, Tom Sensky, Richard Petty, Paul M. Copeland, G. Savron, S. Grandi, L. Michelacci, F.M. Saviotti, G. Bartolucci, S. Conti, G. Trombini, L. Bovicelli, C. Orlandi, G.A. Fava, Ayuso Mateos, Bayon Perez, Santo-Domingo Carrasco, J de Salas Jimenez de Azcarate, D. Olivares, Franco Baldoni, Bruno Baldaro, Mauro Ercolani, Emilio Emili, Giancarlo Trombini, G. Burloux, P. Forestier, J. Dalery, J. Guyotat, Francisco J. Vaz-Leal, Calvo Sagardoy, Fernandez Ashton, Ayuso Mateos, Bayon Perez, Santo-Domingo Carrasco, M. Takei, S. Nozoe, H. Tanaka, Y. Soejima, Y. Manabe, I. Takayama, T. Yamanaka, Morten Birket-Smith, Helle Charlotte Knudsen, Jørn Nissen, Niels Blegvad, Ole Køhler, Dorte Rasmussen, Søren Worm-Petersen, Kathleen Franco, Nancy Campbell, Marijo Tamburrino, Steve Jurs, Judith Pentz, Cynthia Evans, Hans Kordy, Michael von Rad, Wolfgang Senf, Per Fink, Jørgen Jensen
Journal: Psychotherapy and Psychosomatics (1989)
Efficacy of a novel cytotoxic polybisphosphonate for treatment of bone metastasis in castration-resistant prostate cancer (CRPC).
Authors: Sten Nilsson, Henriette Lindberg, Camilla Thellenberg-Karlsson, Claes Nyman, Marcela Marquez, Lena Lennartsson, René Blom, Enrique Castellanos, Anders R Holmberg
Journal: Journal of Clinical Oncology (2015)

e16065 Background: A cytostatic polybisphosphonate was developed for Tx of mCRPC. It has a) anti-resorptive effects, osteoclast inhib., b) tum. cell spec./tox, confirmed in in-vivo models. Tox. study shows high tolerability. Animal PK study has shown T½ < 3 hrs; principal accumulation in liver, spleen, kidneys. Methods: Clin phase I/IIa (clinicaltrials.gov NCT01595087): Prim obj: to define MTD of ODX given every 3rd week. Sec. obj: OS, bone metab. and resp. markers, PSA, QoL and PK. Explorative in vitrostudies (basis for rand. phase IIb trial in pts. with docetax-res. mCRPC). A docetax-resist. cell-line was developed from DU145 in escalating conc. of docetax, then continuous growth in docetax 500 ng/ml. Cells subj. to cytotox. exp. with ODX (iCELLigence system and fluorom microculture cytotox assay). Results: Clin Phase I/IIa first-in-man trial (clinicaltrials.gov NCT01595087): 17/28 patients rec. 4-7 doses every 3rd week. No DLTs; max dose adm.: 3.0 mg/kg: no drug-related SAEs. Tx was well tolerated. Efficacy and QoL data w. considerable variability as to be expected in this population of pts. w. mCRPC. Max blood conc. ODX: 110-160 fmol/mL; 85-90 % cleared within first 1 hr. Efficacy of ODX in docetax-res DU145TR: A dose-dependent cytotox effect seen when adding ODX in “sub-clin.” doses. All cells were apparently killed in the clin. relevant dose 6 uM. Conclusions: ODX is a novel drug cand. w. high cytotox. efficacy in vivo and in vitro, even in highly docetax-res. cells. Animal studies and Phase I trial show excellent tolerability. Studies now ongoing to elucidate whether short-term treatment is as efficacious as continuous treatment and whether some cells de facto may develop resistance also to this new treatment concept. A multicenter rand. double-blind pbo. controlled trial (EudraCT 2014-002054-39) starts Q1 2015 in mCRPC pts failing docetax and/or cabazitaxel AND abiraterone and/or enzalutamide. Clinical trial information: NCT01595087.
Surgery; A Practical Treatise with Special Reference to Treatment.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal