tbuckley/cabot-search huggingface dataset:
Harold Shipman
Authors: T. Jackson
Journal: BMJ (2004)

A general practitioner and murdererFew doctors have had as great an impact on British medicine as Harold Shipman.When he and his colleagues qualified from Leeds Medical School in 1970, none of them would ever have imagined that his obituary in the BMJ would have opened with such a sentence.But his impact, and his legacy, is incalculable.Few lives can have raised so many questions about how we practise and regulate medicine.Britain's general practitioners are frequently the cornerstone of their community, offering care, compassion, and continuity.In return they are trusted-quite remarkably trusted.Shipman betrayed that trust in the most appalling and distressing way, killing at least 215, and possibly 260, of his patients.Harold Frederick Shipman was born in Nottingham in 1946, the son of a lorry driver.No one in his family had ever been to university.While he was taking his A levels, his mother died from cancer at the age of 42.He met his wife, Primrose Oxtoby, at a bus stop while he was at Leeds University, and they married in 1966.They had four children.Apart from the death of his mother, there was nothing unusual about his early years.At medical school, Fred-the name by which he was known throughout his later life-stood out only by being entirely unremarkable.So far, so normal.Shipman became a general practitioner in Todmorden, West Yorkshire, in 1974.But something had clearly happened to him.By 1976 he was self administering pethidine obtained by fiddled prescriptions.He was taken to court, fined £600 by magistrates, referred to a psychiatric unit near York, and was issued with a warning by the General Medical Council but was not struck off.By 1977 he had joined a group practice in Hyde but his violent mood swings made the partnership untenable and in 1992 he set up in singlehanded practice.No one knows when the killing first started, but from this point it escalated out of control.He killed people by injecting them with opiates, often at home, sometimes in the surgery.In 1998 another general practitioner in Hyde told the coroner of her suspicions, but after a police investigation it was felt that no further action was needed, and the killings continued.
Antiemetic prophylaxis (AP) in our clinical practice: are we doing it right?
Authors: E. Vasile, G. Musettini, A. Sbrana, A. Farnesi, I.M. Brunetti, L. Galli, E. Biasco, A. Falcone, S. Ricci, A. Antonuzzo
Journal: Annals of Oncology (2016)
Expanded Tuberculosis Surveillance and Tuberculosis Morbidity—United States, 1993
Journal: JAMA (1994)

Because of the resurgence of tuberculosis (TB) in the United States, in 1987 the Advisory Committee for the Elimination of Tuberculosis recommended the strengthening of TB surveillance to improve monitoring and to assist in targeting groups at risk for disease. In addition, because of outbreaks of nosocomial multidrug-resistant TB (MDR-TB) in New York and Florida during 1990-1992, in 1992, the National MDR TB Task Force recommended that drug-susceptibility testing be performed on all initial and final Mycobacterium tuberculosis isolates from each TB patient and that the results be reported to CDC. In January 1993, in conjunction with state and local health departments, CDC implemented an expanded surveillance system for TB. This report summarizes final TB surveillance data for 1993, compares findings with previous years, and provides information on expanded surveillance.
The Presence of MDS-like Phenotypic Abnormalities (MDS-PA) Identifies Newly Diagnosed Multiple Myeloma (MM) Patients with MDS/AML-Related Somatic Mutations and Inferior Survival
Authors: Bruno Paiva, Noemi Puig, Maria Teresa Cedena, Iria Vazquez, Carmen Chillon, Yanira Ruiz, Joaquin Martinez-Lopez, Ramon Garcia-Sanz, Marcos González, Xabier Agirre, Maria-Jose Calasanz, Leire Burgos, Diego Alignani, Felipe Prosper, Sergio Matarraz, Alberto Orfao, Albert Oriol, Ana Isabel Teruel, M Asuncion Echeveste, Raquel De Paz, Felipe De Arriba, Miguel-T Hernandez, Gemma Azaceta, Rafael Martinez, Maria-Victoria Mateos, Joan Bladé, Juan José Lahuerta, Jesus San Miguel
Journal: Blood (2016)
PHILADELPHIA LETTER.
Authors: None Philadelphia.
Journal: JAMA (1884)

Philadelphia, Oct. 31, 1884. <h3>Dear Doctor:</h3> —Our schools are fairly at work, and it would seem as though with the array of talent offered in our city that we ought to educate<i>medically</i>to a certain extent. What we do turn out, may seem good enough for the outside world, but it would seem as though for home use it were of no value. We are led to this view by the recent selections by two of our schools. The Jefferson has always preferred to import her professors, and perhaps she knew so well the calibre of her graduates that she had reason to look elsewhere. But now comes the University whose trustees are compelled to look to a foreign land for the occupant of a chair. As if to confirm the view as above, our almshouse has been compelled to import its head nurse from England. We have had
Perinatal Mortality and Prolonged Pregnancy
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Dictionary of Antibiosis
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nederlands Tijdschr Geneeskunde, Amsterdam
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A multivariate analysis of risk factors for preeclampsia
Authors: B. Eskenazi
Journal: JAMA (1991)

<h3>Objective.</h3> —To determine, in a multivariate analysis, risk factors for preeclampsia that could be observed early in pregnancy and to establish whether these risk factors are different for nulliparas and multiparas. <h3>Design.</h3> —A case-control study of preeclampsia. <h3>Setting.</h3> —Women who gave birth at Northern California Kaiser Permanente Medical Centers in 1984 and 1985. <h3>Participants.</h3> —Preeclamptic cases (n =139) were determined from discharge diagnosis of severe preeclampsia and by confirmation of blood pressures and proteinuria from medical records. Controls (n = 132) were randomly selected women who had no discharge diagnosis of any hypertensive disorder of pregnancy and who had no evidence of hypertension or proteinuria from medical record review. <h3>Main Variables Examined.</h3> —Medical records were abstracted for information regarding maternal age, race, previous pregnancy history, family medical history, socioeconomic status, employment during pregnancy, body mass, and smoking and alcohol consumption. <h3>Results.</h3> —Multiple logistic regression analyses confirmed that case patients were more likely than control patients to be nulliparous (adjusted odds ratio [OR], 5.4; 95% confidence interval [CI], 2.8 to 10.3) and that preeclampsia in a previous pregnancy greatly increased the risk in a subsequent one (adjusted OR, 10.8; 95% CI, 1.2 to 29.1). However, regardless of parity, preeclamptic women were also more likely to be of high body mass (adjusted OR, 2.7; 95% CI, 1.2 to 6.2), to work during pregnancy (adjusted OR, 2.1; 95% CI, 1.1 to 4.4), and to have a family history of hypertension (adjusted OR, 1.7; 95% CI, 0.92 to 3.2). Having a previous history of a spontaneous abortion was protective but only in multiparous women (adjusted OR for multiparas, 0.09; 95% CI, 0.02 to 0.48). In contrast, being black was a significant risk for preeclampsia but only in nulliparous women (adjusted OR for nulliparas, 12.3; 95% CI, 1.6 to 100.8). <h3>Conclusions.</h3> —There are a number of risk factors for preeclampsia that may be determined early in a woman's pregnancy. Multiparas and nulliparas share certain risk factors but not others. A cohort investigation is needed to determine the ability of these risk factors to predict who develops preeclampsia. (<i>JAMA</i>. 1991;266:237-241)
Reply:
Authors: David van der Poorten, Jacob George
Journal: Hepatology (2008)

We thank Drs. Dogru and Teoman for their interesting comments regarding our recent article on the importance of visceral fat to the pathogenesis of nonalcoholic steatohepatitis.1 Our study showed visceral fat to be a key mediator of steatohepatitis independent of insulin resistance and importantly, independent of a diagnosis of metabolic syndrome (MetS). We agree that all components of the MetS can variably be associated with both insulin levels and those of circulating adipokines. However, the MetS (as defined by various criteria) has been developed purely for operational reasons. This syndrome is the consequence, rather than the cause of metabolic dysregulation. For this reason, in our multivariate analysis, we controlled the effects of visceral fat for both circulating adipokines and insulin sensitivity as measured by the homeostasis model assessment of insulin resistance (HOMA-IR). The HOMA-IR has been shown to correlate well with the results of the euglycemic-hyperinsulinemic clamp in patients with and without type 2 diabetes, even in the presence of metformin or sulfonylureas.2, 3 Thus, any confounding effect of MetS components, or indeed the medications used to treat these components, will have been reflected and controlled for by HOMA-IR levels and those of the circulating adipokines. We are happy to provide some additional results that clarify the relationship between visceral fat and the other components of the MetS (Table 1). These demonstrate that the most marked changes in visceral fat occur with increasing dysregulation of glucose handling, while those associated with dyslipidemia and hypertension did not reach statistical significance. When the association between these individual metabolic variables and necroinflammation and fibrosis in nonalcoholic steatohepatitis was considered, only MetS glucose (P = 0.04) was significant, while elevated blood pressure (P = 0.35), elevated triglycerides (P = 0.9), and low high-density lipoprotein (P = 0. 13) were not associated. Given that we have already specifically controlled for the effects of insulin sensitivity, we did not further analyze the data. David van der Poorten*, Jacob George*, * Storr Liver Unit, Westmead Millennium Institute, University of Sydney, Westmead, NSW, Australia.
Volumetric Analysis. Volume II: Titration Methods: Acid-Base, Precipitation, and Complex-Formation Reactions
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A phase II study of weekly docetaxel and carboplatin in stage IIIB (with effusion) or stage IV non-small cell lung cancer patients age <65 and performance status 2
Authors: C. H. Weissman, J. F. Sandbach, R. J. Brooker, D. Ilegbodu, L. Asmar
Journal: Journal of Clinical Oncology (2004)

7276 Background: Primary goals of therapy for advanced non-small cell lung cancer (ANSCLC) are an increased survival time, palliation of symptoms, and prolonged time to progression (TTP). This study was designed to explore if ANSCLC patients (pts) with ECOG PS 2 and age ≤65 years could benefit from systemic chemotherapy with acceptable toxicities. Methods: Fifty-nine eligible pts with stage IIIB (effusion) or stage IV NSCLC were registered on study. Patients received docetaxel (Taxotere®) 35 mg/m2 and carboplatin AUC=2 on Days 1, 8, and 15 every 28-day cycle (maximum 8 cycles). Endpoints were 1-year survival, tumor response, TTP, and safety. Results: Among the 59 eligible pts, 1 never received study drug, 58 pts were evaluable for safety, and 49 for response; 9 pts were non-evaluable due to: palliative XRT (1), withdrawal of consent (2), toxicities (1 each; dyspnea, weakness, allergy to study drug) and other illness (3). Responses were: 1 CR (2%), 5 PR (10%), 22 SD (45%), and 21 PD (43%). The 1-year survival was 28%; median survival was 6.0 months (range, <1–24.3). The 1-year progression-free survival was 14% with a median TTP of 3.7 months (range, <1–22.8) and median duration of response for CR+PR was 5.4 months (range, 2.3–9.7). Patients received a median of 3 cycles (range, 1–9); 14 pts (24%) had dose reductions, mainly due to toxicities. The primary Grade 3 or 4 toxicities were neutropenia and fatigue (10.2% each), nausea (8.5%), dehydration (6.8%), and vomiting (5.1%). All 43 deaths were due to PD. Toxicities of this regimen are comparable to other chemotherapy regimens used in this population, thus it may be an alternative treatment choice for patients with ANSCLC who are ≤65 years and PS 2. Conclusions: These results confirm the relatively poor outcome of PS 2 pts with ANSCLC. The overall benefit of chemotherapy doublets, compared to monotherapy, in this patient population remains to be proven. Supported by Aventis Pharmaceuticals, Bridgewater, NJ No significant financial relationships to disclose.
Medicinal Research Reviews: Aims and Scope
Authors: Joe Tomaszewski
Journal: Medicinal Research Reviews (2015)

The journal publishes timely critical reviews of topics related to medicinal research, broadly defined, to which the authors have made significant contributions.Appropriate topics include, but are not limited to, the underlying pathophysiology of important diseases and disease vectors; therapeutic approaches to the treatment of various diseases; the properties of molecular targets for therapeutic agents; important new methodologies facilitating the search for therapies; genomics and proteomics; structure-activity correlations of drug series; the development of new imaging and diagnostic tools; drug metabolism; drug delivery; and chemical, pharmacological, pharmacokinetic, pharmacodynamic, and clinical characteristics of important drugs.Reviews are mainly solicited by the editors; however, voluntary contributions are also encouraged.In the latter case, potential authors are asked to contact the Editor-in-Chief with an outline before beginning to write in order to avoid duplication of effort and to ensure suitability of the topic and the level of coverage.
Acyclovir suppression of frequently recurring genital herpes. Efficacy and diminishing need during successive years of treatment
Authors: S. E. Straus
Journal: JAMA (1988)

Forty-seven patients with frequently recurring genital herpes participated in one or more of five sequential trials of oral suppressive therapy with 200 mg of acyclovir three times daily from four to 12 months' duration. The prolonged use of acyclovir was extremely well tolerated, and treatment efficacy was sustained through successive studies. Recurrences in eight patients with repeated treatment "failures" were more effectively suppressed with higher doses of acyclovir. All patients experienced recurrent infections after the treatments were completed; however, the mean time to recurrence following each treatment period became progressively longer, and resumption of suppressive therapy was no longer warranted for ten patients. These data indicate the efficacy and safety of chronic suppressive therapy with acyclovir and the value of interrupting prolonged treatment to assess its further need. (<i>JAMA</i>1988;260:2227-2230)
THE NECESSITY OF CLEAR THINKING IN MILK MODIFICATION
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Go
Authors: Kimberly D. Manning
Journal: Annals of Internal Medicine (2012)

On Being a Doctor3 July 2012GoKimberly D. Manning, MDKimberly D. Manning, MDFrom Emory University School of Medicine, Atlanta, GA 30303.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-157-1-201207030-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail “Did you get a chance to see him?” These were the words spoken by our mutual friend who had worked with us for the past several years. They were simply a placeholder, an offhand remark, some obligatory small-talk before the discussion of matters at hand. My answer, however, caught her by surprise.“I haven't been able to bring myself to see him like that. I keep wanting to go, but I just can't.” I slumped in shame. You were my friend after all. I should have been there by now.She walked behind my desk and placed a hand on ... Author, Article, and Disclosure InformationAffiliations: From Emory University School of Medicine, Atlanta, GA 30303.Note: The author dedicates this article in memory of Ildefonso Tellez, MD, MPH.Corresponding Author: Kimberly D. Manning, MD, Emory University School of Medicine, 49 Jesse Hill Jr. Drive SE, Atlanta, GA 30303; e-mail, [email protected]edu. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 3 July 2012Volume 157, Issue 1Page: 73-74KeywordsEmotionsHeartPostural controlRunningShouldersSmellThoraxTongueUrineWalking ePublished: 3 July 2012 Issue Published: 3 July 2012 Copyright & PermissionsCopyright © 2012 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
First Call for the AMA-RPS Annual Meeting
Authors: M. Therese Southgate
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal