tbuckley/cabot-search huggingface dataset:
A pilot study of tremelimumab – a monoclonal antibody against CTLA-4 – in combination with either trans catheter arterial chemoembolization (TACE) or radiofrequency ablation (RFA) in patients with hepatocellular carcinoma (HCC).
Authors: Austin G. Duffy, Oxana V. Makarova-Rusher, Sid P Kerkar, David E Kleiner, Suzanne Fioravanti, Melissa Walker, Stephanie Carey, William Douglas Figg, Seth M. Steinberg, Victoria Anderson, Nadine Abi-Jaoudeh, Elliot Levi, Bradford J. Wood, Tim F. Greten
Journal: Journal of Clinical Oncology (2015)

4081 Background: Tremelimumab is a fully human monoclonal antibody that binds to CTLA-4 expressed on the surface of activated T lymphocytes and results in inhibition of B7-CTLA-4-mediated downregulation of T-cell activation. Both transcatheter arterial chemoembolization (TACE) and radiofrequency ablation (RFA) have been shown to induce a peripheral immune response which may enhance the effect of anti-CTLA4 treatment in patients with advanced HCC. Methods: Patients with HCC [Childs Pugh A/B7; Barcelona Clinic Liver Cancer Stage B/C; ECOG 0/1; sorafenib refractory/intolerant (BCLC stage C only)] were enrolled in a pilot study of Tremelimumab at 2 dose levels (DL1 and DL2) until PD (irRECIST). Subtotal TACE or RFA was performed during study week 6 with DLT evaluation period encompassing first 8 weeks of study. Tumor biopsy at baseline and at time of RF/TACE. Results: 20 pts were enrolled with N = 18 evaluable for primary endpoint. Baseline characteristics: M:F 15:3; Median age = 54(range 42-76); Cirrhosis present in 13pts; BCLC Stage B/C: 4/14; Hepatitis B/C/neg: 4/10/4. 8 pts received TACE, 10 underwent RFA during week 6 of tremelimumab therapy. No DLT encountered. Most common toxicity was pruritus. One patient developed pulmonitis and was taken off study but remains disease-free at 16months. Of N = 10 pts evaluable for response outside of TACE/RFA-treated lesion 4 (40%) achieved confirmed partial responses. 5 of 7 pts with quantifiable HCV experienced a marked reduction in viral load. 6-week tumor biopsies showed immune cell infiltration on all evaluable patients. Median PFS for the study population (N = 17) was 7.4months. Conclusions: Tremelimumab in combination with subtotal TACE or RFA in patients with advanced HCC is safe and feasible. Obtaining tumor biopsies at baseline and at the time of RFA/TACE is safe. Evidence of immune cell infiltration was seen on evaluable patients. Encouraging clinical activity has been seen with objective confirmed responses, TTP 7.4m and possibly surrogate reductions in HCV viral load. Clinical trial information: NCT01853618.
Overexpression of Interleukin-1 Receptor Antagonist Provides Cardioprotection Against Ischemia-Reperfusion Injury Associated With Reduction in Apoptosis
Authors: Ken Suzuki, Bari Murtuza, Ryszard T. Smolenski, Ivan A. Sammut, Noriko Suzuki, Yasufumi Kaneda, Magdi H. Yacoub
Journal: Circulation (2001)

Background Interleukin-1 (IL-1) plays a role in mediating acute inflammation during ischemia-reperfusion (I/R) injury in the heart, which leads to both necrosis and apoptosis of cardiomyocytes. IL-1 receptor antagonist (IL-1ra) is known to inhibit the effects of IL-1α and IL-1β, resulting in attenuated inflammatory injury, and to protect cells from IL-1β–induced apoptosis in vitro. We hypothesized that IL-1ra overexpression would provide cardioprotection by reducing inflammation-mediated myocardial damage including apoptosis after I/R injury in vivo. Methods and Results Rat hearts were transfected with human secreted–type IL-1ra gene by intracoronary infusion of Hemagglutinating Virus of Japan liposome and were heterotopically transplanted. IL-1ra overexpression in these hearts was confirmed by enzyme immunoassay and immunohistochemistry. Myocardial tolerance of the transplanted heart was evaluated with the use of a novel system in which the heart, existing within the recipient’s abdomen, was given 30 minutes of ischemia by left coronary artery occlusion and 24 hours of reperfusion. Consequently, infarct size was decreased in IL-1ra–transfected hearts compared with control-transfected ones (26.9±3.2% versus 46.2±3.0%, P =0.001), corresponding to lower myocardial myeloperoxidase activity (2.20±0.69 versus 6.82±1.19 U/g wet wt, P &lt;0.001) and decreased neutrophil infiltration in histological study. Terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling and DNA-laddering studies demonstrated that cardiomyocyte apoptosis was attenuated in IL-1ra–transfected hearts (21.4±3.3 versus 41.4±3.4%, P =0.002), correlating with reduced post I/R upregulation of Bax, Bak, and caspase-3. Conclusions IL-1ra introduced by gene transfection protected myocardium from I/R injury by attenuating the inflammatory response, which was associated with decreased apoptosis. This suggests a potentially important role of IL-1/IL-1ra in myocardial I/R injury and the value of IL-1ra-gene therapy for myocardial preservation.
Psychiatry
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Book Review Artificial Sunlight and Its Therapeutic Uses . By Francis Howard Humphris, M.D., (Burx), F.R.C.P. (Edin.), M.R.C.S. (Eng.), L.R.C.P. (Lond.), L.M. (Rot., Dublin), D.M.R. and E. (Cantab.) Fifth Edition. Price $3.25.
Journal: New England Journal of Medicine (1929)
Seasonal trends in US asthma hospitalizations and mortality
Authors: K. B. Weiss
Journal: JAMA (1990)

Asthma morbidity is known to exhibit seasonal periodicity. Yet the relationship between trends in morbidity vs mortality is not known. This report describes and compares the seasonal variation in asthma hospitalizations and mortality in the US population. During 1982 through 1986, both mortality and hospitalizations demonstrated periodic seasonal trends that were age specific and did not differ by sex, race, or region. For persons aged 5 through 34 years, hospitalizations peaked in September through November, whereas mortality trends peaked in June through August. A disproportionate number of the summer deaths in this age group occurred out of the hospital. For individuals 65 years old or older, both asthma hospitalizations and mortality demonstrated increases during December through February. The results of this study demonstrate age-specific seasonal variations in the clinical expression of asthma. Perhaps the treatment and prevention of asthma hospitalizations and mortality might be improved through further understanding of these trends. (<i>JAMA</i>. 1990;263:2323-2328)
Hypothermia
Authors: H. H. ROTMAN
Journal: Annals of Internal Medicine (1979)

Letters1 February 1979HypothermiaH. H. ROTMAN, M.D.H. H. ROTMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-2-273 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In the excellent review of hypothermia in the October issue (Ann Intern Med89:519-527, 1978), Dr. Reuler states that "arterial blood gases must be corrected for body temperature" and that "because these values are standardly measured at 37 °C, direct communication to the laboratory is necessary in order to obtain results that can be rationally interpreted and applied to management." Does Dr. Reuler intend that the laboratory measure the sample at the patient's core temperature, or simply to supply an arbitrary correction retrievable from the literature? The first possibility presents an enormous logistical problem in a busy...References1. MACLEANEMSLIE-SMITH DD: Accidental Hypothermia. Oxford, Blackwell Scientific Publications, 1977, pp. 116-122 Google Scholar2. PATTERSONSONDHEIMER RH: Assessing acid-base metabolism with samples of arterial blood obtained from hypothermic subjects. J Surg Res 6:19-23, 1966 CrossrefMedlineGoogle Scholar1. ARNOLDEICHENBERGER JC: The hydraulic sarong: emergency treatment device for accidental hypothermia. J Am Coll Emergency Physicians 4:438-439, 1975 CrossrefGoogle Scholar1. BUTLER R: Energy and aging. The impact of rising energy costs on older Americans, in Testimony Before the U.S. Senate Special Committee on Aging, 5 April 1977. Washington, D.C., U.S. Department of Health, Education, and Welfare, 1977 Google Scholar2. WOLLNERSPALDING LJ: Temperature regulation, in Textbook of Geriatric Medicine and Gerontology, edited by BROCKLEHURST JC New York, Churchill Livingstone, 1973, pp. 235-244 Google Scholar3. MACMILLANCORBETTJOHNSONCRAMPTON SMITHSPALDINGWOLLNER AJRAJL: Temperature regulation in survivors of accidental hypothermia of the elderly. Lancet 2:165-169, 1967 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHypothermia Treatment Needs Controlled StudiesFRANCIS P. CHINARD, M.D.Correction: Temperature Correction for Oxygen TensionJAMES B. REULER, M.D. 1 February 1979Volume 90, Issue 2Page: 273-274KeywordsBloodHypothermiaResearch laboratoriesTemperature Issue Published: 1 February 1979 PDF downloadLoading ...
Facilitated Psychiatric Advance Directives: A Randomized Trial of an Intervention to Foster Advance Treatment Planning Among Persons with Severe Mental Illness
Authors: Jeffrey W. Swanson, Marvin S. Swartz, Eric B. Elbogen, Richard A. Van Dorn, Joelle Ferron, H. Ryan Wagner, Barbara J. McCauley, Mimi Kim
Journal: American Journal of Psychiatry (2006)

Objective: Studies show a high potential demand for psychiatric advance directives but low completion rates. The authors conducted a randomized study of a structured, manualized intervention to facilitate completion of psychiatric advance directives. Method: A total of 469 patients with severe mental illness were randomly assigned to a facilitated psychiatric advance directive session or a control group that received written information about psychiatric advance directives and referral to resources in the public mental health system. Completion of an advance directive, its structure and content, and its short-term effects on working alliance and treatment satisfaction were recorded. Results: Sixty-one percent of participants in the facilitated session completed an advance directive or authorized a proxy decision maker, compared with only 3% of control group participants. Psychiatrists rated the advance directives as highly consistent with standards of community practice. Most participants used the advance directive to refuse some medications and to express preferences for admission to specific hospitals and not others, although none used an advance directive to refuse all treatment. At 1-month follow-up, participants in the facilitated session had a greater working alliance with their clinicians and were more likely than those in the control group to report receiving the mental health services they believed they needed. Conclusions: The facilitation session is an effective method of helping patients complete psychiatric advance directives and ensuring that the documents contain useful information about patients’ treatment preferences. Achieving the promise of psychiatric advance directives may require system-level policies to embed facilitation of these instruments in usual-care care settings.
Section 6.— Connective Tissue Diseases
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
<i>Erratum</i>: Vol. 66, No. SS-19
Journal: MMWR Morbidity and Mortality Weekly Report (2017)

In the report "Rapid Laboratory Identification of Neisseria meningitidis Serogroup C as the Cause of an Outbreak -Liberia, 2017," on page 1145, the figure title was not included in the printed version of this report.The figure title should have read "FIGURE.Date of onset of outbreak cases (N = 31), by laboratory and outcome status -Liberia, 2017.*"
INTESTINAL EXTRACTION OF ADSORBED ALKALOIDS
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
US Infertility Rate Drops, But Problems Getting Pregnant Persist
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ON THE NATURE OF RABIES AND ANTIRABIC TREATMENT
Authors: D. Semple
Journal: BMJ (1919)

PERSONS bitten by rabid anim-lals should apply for treat- ment as soon as possible; not a day, not even one hour, should be unnecessarily wasted.This applies more especi- ally to cases in which the bites (or other methods ofiilfec- tion) are situated ontlle head,fa.ce,or neck, and to severe bites on the wrists or hands, or on the exposed shin where nerves are plentiful.The object aimed at is to immunize the patient against rabies before the virus implanted in the wound by the animal which inflicted tlle bite reaches tlle nerve centres.Should the virus succeed in reaching thenerve centres before immunity has been conferred, no treatment yet devised will save the patient.These few remarks, taken incoonjunction with the explanations in Section IV as to how infection takes place, are the reasons why early treatment is advocated.Antirabic Vaccines.The material used for antirabic treatment is prepared either from the spinal cords, or from tlle brain, medulla, and spinal cords of rabbits wlich have died from rabies after inoculation with "ifixed " rabies virus.The virus, being of a fixed virulence, may be termed a vaccine " when prepared for use; but the metlhod of preparation varies in different Pasteur Institutes.Dried Cord MVethod.Pasteur's original system was to dry the spinal cordshung in glass jars over caustic potash or caustic soda, under fixed conditions as to time, temperature, humidity of the atmio- sphere and the exclusion of light, and for varying periods up to fourteen days from the time the fresh cords were removed from the rabbits.When a cord was treated under these
Rootless wanderers.
Journal: BMJ (1973)

Of all the issues which have split the ranks of psychiatrists in the past 10 years or so none has produced a wider schism than the pronouncement contained in the Hospital Plan, 1962, in which it was predicted that by 1975 half our mental hospitals would be closed and their functions divided be- tween community agencies, or "community care," and psy- chiatric units in general hospitals.The government of the day and indeed succeeding governments chose to ignore the protestations of those psychiatrists who opposed the plan and actively encouraged the rundown of the mental hospi-
Incorrect Spending Figure in an Editorial
Authors: Willemijn Jansen, Rik Ossenkoppele, Pieter Visser
Journal: JAMA (2015)

positivity between participants with SCI and those who were cognitively normal.Second, they indicate that the absence of correction for education in the analysis presented in Figure 2 could have biased our findings because of differences in educational level between participants with normal cognition and SCI.We have repeated the analysis for the data shown in Figure 2 with correction for education and found no statistically significant difference in amyloid positivity between participants with normal cognition and patients with SCI (mean difference, -4% [95% CI, -13% to 5%]; P = .35).Third, it is suggested that our definition of SCI was limited and that the normal cognition group may have included participants with SCI.The studies included in our metaanalysis adopted different inclusion criteria for SCI.We defined SCI as referral to a memory clinic in the absence of objective impairment because this could be implemented reliably across studies.This definition also seems compatible with a definition of SCI that is supposed to be more specific for AD. 2 However, we cannot exclude the possibility that the normal cognition group included participants with SCI according to other definitions.Yet in additional analyses, we selected 6 studies from our meta-analysis that explicitly excluded participants with cognitive complaints from the normal cognition group and still found no statistically significant difference in amyloid positivity between the participants with normal cognition (n = 214) and patients with SCI (n = 413; mean difference, 1% [95% CI, -5% to 7%]; P = .77).We agree with Wagner and Jessen that more research is needed on the standardization of the SCI construct.Future studies combining biomarkers and long-term neuropsychological and clinical follow-up need to establish whether there is a specific definition of SCI that is associated with amyloid positivity and that is predictive for AD.
SPECIAL NOTICES.
Journal: JAMA (1884)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Intracoronary stents
Authors: N. G Uren, N. A. Chronos
Journal: BMJ (1996)

responsible for the increase in incidence of gastroschisis.Fur- ther structured prospective studies of pregnancies complicated by gastroschisis are required to define precise risk factors so that preventive measures may be taken.While this can be done on a relatively small scale in individual units, there is no doubt that countrywide epidemiological data would also be very helpful.It would seem that the statutory reporting system in England and Wales is currently inadequate for this purpose, and the development of more local (or perhaps national) congenital malformation registers such as exist in North West Thames region and some other regions should be encouraged.