tbuckley/cabot-search huggingface dataset:
TMOD-32. MUTATIONAL ANALYSIS OF THE C11orf95 DOMAIN AND SINGLE CELL RNASEQ PROFILE OF A MOUSE MODEL OF SUPRATENTORIAL EPENDYMOMA
Authors: Kevin Troung, James He, Ericka Randazzo, Jesse Dunnack, Joseph LoTurco
Journal: Neuro-Oncology (2020)

Abstract We used a recently developed mouse model to better understand the cellular and molecular determinants of tumors driven by the oncogenic fusion protein C11orf95-RELA. Our approach makes use of in utero electroporation and a binary transposase system to introduce human C11orf95-RELA sequence, wild type and mutant forms, into neural progenitors. We used single cell RNA-seq to profile the cellular constituents within the resulting tumors in mice. We find that approximately 70% of the cells in the tumors do not express the oncogene C11orf95-RELA and these non-oncogene expressing cells are a combination of different non-tumor cell cell-types, including significant numbers of T-cells, and macrophages. The C11orf95-RELA expressing tumor cells have a unique transcriptomic profile that includes both astrocytic and neural progenitor marker genes, and is distinct from glioblastoma transcriptomic profiles. Since C11orf95-RELA is believed to function through a combination of both activation of NF-κB response genes by constitutive activation of RELA, and genes not activated by NF-κB, we assessed the expression of NF-κB response genes across the populations of cells in the tumor. Interestingly, the genes that best defined the oncogene expressing tumor cell population were not enriched for NF-κB response genes relative. We hypothesized that the C110rf95 domain may function to bring RELA transcriptional activation to inappropriate non-NF-κB targets, and we therefore performed a point mutation analysis of the C110rf95 domain. We found that mutations in either of the cysteines or histidines that make up a possible zinc finger domain in C11orf95 eliminate the ability of the fusion to induce tumors. In cell lines, these loss-of-function point mutants still trafficked to nuclei, and activated NF-κB pathways. We are currently using RNAseq and CRISPR loss-of function to identify genes downstream of C11orf95-RELA that are required for tumorigenesis.
PHYSICIANS AND DENTISTS.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ABO blood group and the risk of lung cancer: Multicenter, case-control, observational study.
Authors: Gungor Utkan, Yuksel Urun, Ayten Kayi Cangir, Omur Berna Oksuzoglu, Nuriye Özdemir, Derya Gokmen Oztuna, Gokhan Kocaman, Ahmet Demirkazik, Ilker Okten, Fikri Icli
Journal: Journal of Clinical Oncology (2012)

1596 Background: The role of genetic factors in the development of cancer is widely accepted. Previous studies have observed an association between ABO blood group and risk of certain malignancies, including pancreatic and gastric cancer. The data on the role of ABO blood group and Rh factor in lung cancer is limited. Methods: All patients who had Lung cancer (LC) and treated between 2000-2011 at the involved centers with defined ABO/Rh were included in our retrospective reviews of tumor registry records. A group of volunteer healthy blood donors of Turkish Red Crescent between 2004 and 2011 were identified as a control group. The relationship of ABO/Rh with clinical features such as age at diagnosis, histological subtype and sex were evaluated. We compared the distributions of ABO/Rh among 1954 patients and 3,022,883 controls. Among LC patients, differences between each of aforementioned ABO/Rh groups with respect to various clinical features were explored, respectively. Results: Of these patients the median age was 62 (range: 17-90). The 84% of patients were male. Overall distributions of ABO blood groups as well as Rh factor were statistically different between patients (43.6% A, 8.3% AB, 17.3% B, 30.8% O, and 86.3% Rh+) and controls (42.2% A, 7.6% AB, 16.3% B, 33.9% O, and 87.7% Rh+) (p=0,03). In addition, there were statistically significant differences between patients and controls with respect to O vs. nonO (p=0.004) and marginal significance for A vs. nonA (p=0,065), B vs. nonB (p=0,076), and Rh+ vs. Rh- (p=0,057). Among patients, there weren’t statistically significant differences between blood group with respect to sex and age. However there was statistically significant difference between blood group with respect to histology (p=0,001). Although the distribution of A and O were similar according to histology, patients with squamous histology had antigen B more frequently than other histological sub types (p=0,009). Conclusions: In the study populations, ABO blood type was statistically significantly associated with the LC and having blood type other than O increases the risk of LC. Further studies are necessary to define the mechanisms by which ABO blood type may influence breast cancer risk.
DICEPHALOUS MONSTER.
Authors: W. K. WEST
Journal: JAMA (1905)

I wish to record the following case of dicephalus, and the facts bearing on its birth: The mother was American, aged 28, and a primipara. Her family history was negative. She had several sisters—all married. There have been no other multiple nor abnormal births in the family. <h3>History.</h3> —The patient is a pale, slight woman, 5 feet tall, weight 125 pounds. She has always enjoyed fairly good health until this pregnancy, no history of syphilis. She first felt fetal movements in December, 1904. January 2, following, she was taken with a severe attack of the grippe of the gastroenteric form. Vomiting and diarrhea persisted for several weeks, and she was able to take but little nourishment. This was further complicated in the second week by a thrombosis of the left femoral vein. She suffered much pain in the leg, which became very much enlarged from the groin to the foot.
339. Sustained, High-Level Expression of Human Acid Alpha-Glucosidase and Correction of Glycogen Storage Disease Type II (GSD II) with an Adeno-Associated Virus 8 (AAV2/8) Vector Containing a Liver-Specific Promoter
Authors: Luis M. Franco, Baodong Sun, Andrew Bird, Haoyue Zhang, Andrea Amalfitano, Y.-T. Chen, Dwight D. Koeberl
Journal: Molecular Therapy (2004)
Farmworker Pesticide Exposure and Community-Based Participatory Research: Rationale and Practical Applications
Authors: Thomas A. Arcury, Sara A. Quandt, Allen Dearry
Journal: Environmental Health Perspectives (2001)

The consequences of agricultural pesticide exposure continue to be major environmental health problems in rural communities.Community-based participatory research (CBPR) is an important approach to redressing health disparities resulting from environmental causes.In this article we introduce a collection of articles that describe projects using CBPR to address the health disparities resulting from pesticide exposure in agricultural communities, particularly the communities of migrant and seasonal farmworkers.The articles in this collection are based on a workshop convened at the 1999 American Public Health Association meeting.The goals in presenting this collection are to provide those endeavoring to initiate CBPR projects needed information, guidelines, and procedures to improve the quality of the CBPR experience; to increase the scientific validity of CBPR projects; and to reduce the potential difficulties and stress of these collaborations.In this introduction we discuss the context in which these projects operate, summarizing background information about farmworkers in the United States, what is known about farmworker pesticide exposure, and the concept of community-based participatory research.Finally, the articles in this collection are summarized, and major themes common to successful CBPR projects are identified.These common features are taking the time to interact with the community, using multiple approaches to engage the different parts of the community, understanding different participants often have different goals, appreciating each group's strengths, valuing community knowledge, and being flexible and creative in conducting research.The final article in this collection describes the translational research program at the National Institute of Environmental Health Sciences (NIEHS) highlighting activities pertinent to the health of rural communities, giving an overview of NIEHS-supported projects addressing health concerns of Native Americans and rural African-American communities in addition to farmworkers, and discussing future plans for CBPR at NIEHS.
Acute Promyelocytic Leukemia Associated with Hypofibrinogenemia
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE ECONOMIC VALUE OF PROTECTING THE WATER-SUPPLIES
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PROPHYLAXIS OF BALDNESS.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Update: Influenza Activity—Worldwide, April-September 1998
Journal: JAMA (1998)

In collaboration with the World Health Organization (WHO), the WHO international network of approximately 110 collaborating laboratories in 83 countries, and U.S. state and local health departments, CDC conducts surveillance to monitor influenza activity and to detect antigenic changes in the circulating strains of influenza viruses. During October 1997-April 1998. influenza activity was moderate to severe in the Northern Hemisphere. Influenza A(H3N2) viruses were predominant, but influenza A(H1N1) viruses were associated with outbreaks, and influenza B viruses were identified sporadically in all regions. Since April 1998, increased influenza outbreak and epidemic level activity, primarily associated with influenza A(H3N2), has been reported in the Southern Hemisphere. This report summarizes worldwide influenza activity during April-September 1998 and the antigenic characteristics of influenza isolates collected during April-September.
An example of atavistic physiology?
Authors: W. D. Snively
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cortical blindness in puerperium
Authors: B. M. Singh
Journal: JAMA (1980)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Computerized tomography of the adrenal gland
Authors: A. J. Epstein
Journal: JAMA (1979)

BEFORE computerized tomography (CT), the detection of adrenal masses and the determination of their size and extent were difficult and often unsuccessful. While invasive techniques such as arteriography and phlebography are highly accurate, they necessitate patient hospitalization, involve high radiation doses, and require considerable operator expertise if complications are to be avoided. Computerized tomography provides an accurate and noninvasive method of evaluating suspected adrenal disease (ie, in patients with clinical and biochemical evidence of Cushing's syndrome, pheochromocytoma, or aldosteronoma). In addition to being technically easy to perform, the examination can be done on an outpatient basis, thus diminishing the overall time and cost of hospitalization. The purpose of this communication is to emphasize the sensitivity, accuracy, and convenience of CT as a screening procedure in patients with suspected adrenal disease. <h3>Technique</h3> In the last three years, our department has performed approximately 4,500 body scans. The earliest scans were performed on
Progesterone and the premenstrual syndrome: a double blind crossover trial
Authors: G. Gotts, L. Dennerstein
Journal: BMJ (1985)

A double blind, randomised, crossover trial of oral micronised progesterone (two months) and placebo (two months) was conducted to determine whether progesterone alleviated premenstrual complaints.Twenty three women were interviewed premenstrually before treatment and in each month of treatment.
Abstracts of a symposium organised by the British Society for Cardiovascular Research
Journal: Cardiovascular Research (1988)

Journal Article Abstracts of a symposium organised by the British Society for Cardiovascular Research Get access Cardiovascular Research, Volume 22, Issue 8, August 1988, Page 584, https://doi.org/10.1093/cvr/22.8.584 Published: 01 August 1988
Infectious diseases
Authors: M. Y. Stoeckle
Journal: JAMA (1993)

The resurgence of tuberculosis (TB) in the United States and the spread of multidrug-resistant strains of TB (MDR-TB) are serious public health threats. As recently as 1989 it seemed possible to plan for the elimination of TB from the United States.<sup>1</sup>Decades of successful control efforts had resulted in a steady decline in the incidence of TB, from more than 84000 cases in 1953 to 22000 in 1984. However, this favorable trend ended in 1985: from 1985 to 1991, there were 39000 more cases than expected, and the annual case rate is increasing. In response to the current epidemic, major efforts in TB infection control and patient care have been initiated. The human immunodeficiency virus (HIV) epidemic seems to be a significant factor in the recent increase in TB cases. The risk of active TB among persons with HIV is exceedingly high. For those with latent tuberculous infection, 7%
Colorado tick fever or ehrlichiosis
Authors: R. T. Ellison
Journal: JAMA (1987)

<h3>To the Editor.—</h3> I read with interest the recent article by Fishbein et al<sup>1</sup>entitled "Unexplained Febrile Illnesses After Exposure to Ticks: Infection With an<i>Ehrlichia?</i>" Although the serological data are very supportive of disease due to<i>Ehrlichia</i>, I would also note that virological and serological studies were apparently not performed for Colorado tick fever (CTF). This latter infection caused by an orbivirus has many similar clinical features to the illness described by Fishbein et al, with fever, chills, headache, myalgias, and abdominal complaints occurring commonly.<sup>2</sup>A biphasic course is characteristic, but occurs in only half the cases. In addition the major laboratory abnormality of CTF is leukopenia, and lymphopenia is also frequently present.<sup>3</sup>Both thrombocytopenia and liver function abnormalities have been described.<sup>4</sup> Despite its name, CTF is endemic throughout the mountainous regions of the western United States and Canada in the distribution of<i>Dermacentor andersoni</i>
Eighth National Conference on Chronic Disease
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Manual of Jurisprudence and Toxicology.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal