tbuckley/cabot-search huggingface dataset:
Skilled Anesthetizers.
Authors: D. H. Galloway
Journal: JAMA (1902)

Chicago, Ill., Feb. 5, 1902. <h3>To the Editor:</h3> InThe Journalof January 25, Dr. Holmes reports a death from chloroform. This report should not be allowed to pass without some comment and perhaps a word of criticism. Scarcely a week passes that does not bring me rumors of deaths or narrow escapes from death from anesthetics, but the reports on such occurrences are altogether too infrequent. We get reports from everything else that happens in surgery, but there seems to be a "conspiracy of silence" which will not allow occurrences in this field to be published. There is no disposition to criticise the person who gave this anesthetic; for all I know he may have been a skilful anesthetizer and every one who administers anesthetics is liable to this experience. Using some of the statements of Dr. Holmes as a text I would like to point out some of
Anicteric carbenicillin hepatitis. Eight episodes in four patients
Authors: F. M. Wilson
Journal: JAMA (1975)

Carbenicillin disodium was temporally associated with eight episodes of a mild reversible anicteric hepatitis characterized by nausea, vomiting, and a tender, somewhat enlarged liver. Serum glutamic and oxaloacetic transaminase as well as alkaline phosphatase levels rose, but serum bilirubin values remained normal. There usually were no signs of concomitant allergy to penicillin, and other penicillins could be given subsequently without ill effects. Biopsy specimens of the liver showed spotty liver cell necrosis with no cholestasis. (<i>JAMA</i>232:818-821, 1975)
The definition of myocardial ischaemia
Authors: R. J Bing
Journal: Cardiovascular Research (1995)

Journal Article The definition of myocardial ischaemia Get access Richard J Bing Richard J Bing Professor of Medicine, Director, Experimental Cardiology Huntingdon Medical Research Institutes, Pasadena, CA, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 29, Issue 1, January 1995, Page 142, https://doi.org/10.1016/S0008-6363(95)90117-5 Published: 01 January 1995
Glucose Toxicity*
Authors: HANNELE YKI-JÄRVINEN
Journal: Endocrine Reviews (1992)

ALARGE number of retrospective and prospective studies have documented that chronic hyperglycemia is closely linked to diabetic microvascular complications, especially retinopathy and neuropathy (1). The incidence and prevalence of diabetic nephropathy also are higher if glycemic control is poor (1), although the development of nephropathy may be limited to patients with a genetic predisposition to hypertension (2). An increased susceptibility to infections is another wellknown consequence of chronic hyperglycemia (3, 4). Although the occurrence of all these complications as well as macrovascular disease have been associated with chronic hyperglycemia, the proposed biochemical mechanisms underlying the structural and functional changes vary widely (Table 1 and Refs. 1–10). Recently, it has become clear that chronic hyperglycemia is not only a marker of poor metabolic control but is itself a regulator of both insulin secretion and action. In contrast to acute hyperglycemia, which stimulates insulin secretion and glucose utilization, chronic hyperglycemia inhibits both and thereby self-perpetuates the diabetic state. These harmful metabolic effects of chronic hyperglycemia have been referred to as “glucose toxicity” (11–13). The ensuing discussion is focused on reviewing our present understanding of the occurrence, pathophysiology, and clinical significance of this phenomenon which already has widened our view of the causes and reversibility of defects in insulin secretion and action in insulin-dependent diabetes mellitus (IDDM) and non-insulin-dependent diabetes mellitus (NIDDM).
BOOK REVIEWS
Authors: H. I. SCHER
Journal: JNCI Journal of the National Cancer Institute (1992)

BOOK REVIEWS Get access Prostate Cancer: Cell and Molecular Mechanisms in Diagnosis and Treatment John T. Isaacs , ed. Plainview, N.Y. : Cold Spring Harbor Lab. Press , 1991 . 287 pp., illus. $60. ISBN 0-87969-368-1 HOWARD I. SCHER, M.D. HOWARD I. SCHER, M.D. Division of Medical Oncology Memorial Sloan-Kettering Cancer Center 1275 York AveNew York, NY 10021 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 84, Issue 22, 18 November 1992, Pages 1751–1752, https://doi.org/10.1093/jnci/84.22.1751-a Published: 18 November 1992
The AMA: a case for membership
Authors: R. D. Moreton
Journal: JAMA (1973)

In thinking of AMA membership, I am reminded of a story. It was during the hunting season, and one day two fellows who had shot a deer started pulling it by the tail toward their car. Then another hunter came along and said, "I think it would be easier if you would pull it by the antlers." The hunters accepted the suggestion and very shortly one said to the other, "This is a lot easier." Then the other man said, "Yup. But do you notice we are getting farther and farther away from the car?" The fictional huntsmen involved in this bit of nonsense may or may not have been physicians. Offered a guess, I would say they were, for this is precisely the response many of us are making toward membership in our county and state medical societies and the AMA. Here we are, confronted with major proposals for
Cardiac Auscultation
Authors: THOMAS KILLIP
Journal: Annals of Internal Medicine (1983)

Letters and Corrections1 December 1983Cardiac AuscultationTHOMAS KILLIP, M.D.THOMAS KILLIP, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-99-6-881 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Rothman and Goldberger (1) recently reviewed the usefulness of aids for cardiac auscultation and noted that their diagnostic efficacy has not been fully evaluated. I would like to supplement the review with several points.Interpretation of murmurs can often be enhanced by careful palpation before auscultation. This is an art neglected by many physicians, especially young house officers. Palpation of a thrill implies that a murmur will be found at that site. In the patient with several murmurs, this observation offers the physician a fixed point from which to analyze other findings. For example, clinically significant valvular...References1. ROTHMAN A and GOLDBERGER A. Aids to cardiac auscultation. Ann Intern Med. 1983;99:346-53. LinkGoogle Scholar2. KILLIP T and LUKAS D. Tricuspid stenosis: physiologic criteria for diagnosis and hemodynamic abnormalities. Circulation. 1957;16:3-13. CrossrefMedlineGoogle Scholar3. KILLIP T and LUKAS D. Tricuspid stenosis: clinical features in 12 cases. Am J Med. 1958;24:836-52. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: THOMAS KILLIP, M.D.Affiliations: Department of Internal Medicine Henry Ford Hospital Detroit, MI 48202 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1983Volume 99, Issue 6 Page: 881-881 Keywords Auscultation ePublished: 1 December 2008 Issue Published: 1 December 1983 PDF downloadLoading ...
Correction: EGF Receptor-Targeted Synthetic Double-Stranded RNA Eliminates Glioblastoma, Breast Cancer, and Adenocarcinoma Tumors in Mice
Authors: Alexei Shir, Manfred Ogris, Ernst Wagner, Alexander Levitzki
Journal: PLoS Medicine (2007)

After this article was published, we were alerted by a reader to a potential problem with Figure 6B.Subsequent investigation determined that this fi gure is indeed incorrect.The two lower panels come from the same tumor rather than different tumors as indicated in the legend.The authors have provided the correct fi gure, substituting images of samples taken from different tumors from the same experiment.
Instructions for Authors
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Paroxysmal Nocturnal Hemoglobinuria And Decay-Accelerating Factor
Authors: W. Rosse
Journal: Annual Review of Medicine (1990)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease 2019 (COVID-19), emerged in China in December 2019 and quickly spread around the globe, killing more than 4 million people and causing a severe economic crisis. ...Read More
Animal Models of Physiologic Markers of Male Reproduction: Genetically Defined Infertile Mice
Authors: Curtis Chubb
Journal: Environmental Health Perspectives (1987)

The present report focuses on novel animal models of male infertility: genetically defined mice bearing single-gene mutations that induce infertility. The primary goal of our investigations was to identify the reproductive defects in these mutant mice. The phenotypic effects of the gene mutations were deciphered by comparing the mutant mice to their normal siblings. Initially testicular steroidogenesis and spermatogenesis were investigated. The physiologic markers for testicular steroidogenesis were steroid secretion by testes perifused in vitro, seminal vesicle weight, and Leydig cell histology. Spermatogenesis was evaluated by the enumeration of homogenization-resistant sperm/spermatids in testes and by morphometric analyses of germ cells in the seminiferous epithelium. If testicular function appeared normal, we investigated the sexual behavior of the mice. The parameters of male sexual behavior that were quantified included mount patency, mount frequency, intromission latency, thrusts per intromission, ejaculation latency, and ejaculation duration. Females of pairs breeding under normal circumstances were monitored for the presence of vaginal plugs and pregnancies. The patency of the ejaculatory process was determined by quantifying sperm in the female reproductive tract after sexual behavior tests. Sperm function was studied by quantitatively determining sperm motility during videomicroscopic observation. Also, the ability of epididymal sperm to function within the uterine environment was analyzed by determining sperm capacity to initiate pregnancy after artificial insemination. Together, the experimental results permitted the grouping of the gene mutations into three general categories. We propose that the same biological markers used in the reported studies can be implemented in the assessment of the impact that environmental toxins may have on male reproduction.
Treatment of chronic renal failure with periodic peritoneal lavage
Authors: V. Vertes
Journal: JAMA (1967)

The cases of 26 patients with terminal renal failure, who no longer responded to conservative management, were evaluated for a program of intermittent peritoneal lavage. Thirteen of these patients were selected for treatment with peritoneal lavage performed once every three weeks with the use of a multiple-puncture technique. It was possible to maintain these patients symptom-free and ambulatory for an average period of six months. No serious complications were encountered with the treatment. The data presented demonstrate that patients with terminal renal failure, who no longer respond to usual treatment, can be supported by intermittent peritoneal lavage provided some residual renal function is present. The presence of 24-hour urine volume of at least 500 cc and a time interval of at least two weeks between the first and need for second peritoneal lavage are the best criteria for assessing the needed residual renal function.
Better estrogen receptor assay in the offing
Authors: E. R. Gonzalez
Journal: JAMA (1981)

Identification of estrogen-dependent breast cancers soon should be faster and easier, thanks to a new assay now being developed by University of Chicago investigators Elwood V. Jensen, PhD, and Geoffrey L. Greene, PhD. Jensen, who is Charles B. Huggins Professor and director of the Ben May Laboratory, as well as professor of biophysics and theoretical biology and of pharmacologic and physiological sciences, recently was awarded the $100,000 1980 Kettering Prize for demonstrating the correlation between estrogen dependency of breast cancers and response of the patient to endocrine therapy. Jensen also developed the first estrogen receptor assay. That assay and its offspring, while extremely useful, remain complicated and expensive. Because they necessitate the use of an ultracentrifuge, they can be performed only at large centers. Breast tissue excised at mastectomy is now routinely shipped to such centers, where radioactively labeled estrogen is used as a marker for the estrogen receptors the
Proctosigmoidoscopy in private practice
Authors: J. H. Powers
Journal: JAMA (1975)

PROCTOSIGMOIDOSCOPY by physicians in private practice performed for the diagnosis and management of benign and malignant lesions of the colon and rectum offers rewarding information that cannot be obtained by any other examination. Visualization of the tumor, excisional biopsy of small lesions, segmental biopsy of larger neoplasms, electrosurgical destruction or removal of benign growths through the sigmoidoscope— all may be accomplished easily and safely in the doctor's office. Hospitalization and more radical therapy are imperative for larger tumors and malignant lesions. The examination requires no special skill; it can be performed safely by any physician with adequate equipment who possesses gentle hands, knowledge of the anatomy of the sigmoid and rectum and a compassionate personality that prompts him to discontinue the procedure when the patient complains of pain— not of discomfort, but "that hurts." During the past five years, as Director of the New York State Proctosigmoidoscopic Teaching Program, I
"No" in Wrong Notation Line
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Survival Effect of Maximal Cytoreductive Surgery for Advanced Ovarian Carcinoma During the Platinum Era: A Meta-Analysis
Authors: R. E. Bristow
Journal: Journal of Clinical Oncology (2002)

PURPOSE: To evaluate the relative effect of percent maximal cytoreductive surgery and other prognostic variables on survival among cohorts of patients with advanced-stage ovarian carcinoma treated with platinum-based chemotherapy. MATERIALS AND METHODS: Eighty-one cohorts of patients with stage III or IV ovarian carcinoma (6,885 patients) were identified from articles in MEDLINE (1989 through 1998). Linear regression models, with weighted correlation calculations, were used to assess the effects on log median survival time of the proportion of each cohort undergoing maximal cytoreduction, dose-intensity of the platinum compound administered, proportion of patients with stage IV disease, median age, and year of publication. RESULTS: There was a statistically significant positive correlation between percent maximal cytoreduction and log median survival time, and this correlation remained significant after controlling for all other variables (P < .001). Each 10% increase in maximal cytoreduction was associated with a 5.5% increase in median survival time. When actuarial survival was estimated, cohorts with ≤ 25% maximal cytoreduction had a mean weighted median survival time of 22.7 months, whereas cohorts with more than 75% maximal cytoreduction had a mean weighted median survival time of 33.9 months—an increase of 50%. The relationship between platinum dose-intensity and log median survival time was not statistically significant. CONCLUSION: During the platinum era, maximal cytoreduction was one of the most powerful determinants of cohort survival among patients with stage III or IV ovarian carcinoma. Consistent referral of patients with apparent advanced ovarian cancer to expert centers for primary surgery may be the best means currently available for improving overall survival.
Gene scene
Authors: T. Randall
Journal: JAMA (1990)

BIOCHEMISTS have identified a novel protein that prevents genetic material from replicating in bacteria, a discovery grounded in basic science that could eventually contribute to far-reaching advances in medicine. The protein, isolated from the common bacteria<i>Escherichia coli</i>, is thought to have counterparts in all living systems. Further understanding of its role in the mechanism that controls cell growth could help unravel the complex processes of embryonic development and tumorigenesis, and lead to more rational designs of antibiotics and therapies for cancer and the acquired immunodeficiency syndrome (AIDS). The discovery was reported recently in the journal<i>Cell</i>by Deog Su Hwang, PhD, postdoctoral fellow, and Arthur Kornberg, PhD, professor of biochemistry at the Stanford (Calif) University School of Medicine (<i>Cell</i>. 1990;63:325-331). Kornberg's earlier research in DNA replication brought him the 1959 Nobel Prize in medicine. He is also noted for his pioneering work in recombinant DNA techniques in the 1970s.
Role of Inhalation Studies with Animals in Defining Human Health Risks for Vehicle and Power Plant Emissions
Authors: Roger O. McClellan
Journal: Environmental Health Perspectives (1983)

Automotive vehicles and power plants using fossil fuels emit a complex array of gases and particulate material. The physical and chemical characteristics of these emissions vary markedly between sources and comprise only a portion of the contributors to air pollution exposure of people. Further, it is well recognized that a single form of self-inflicted air pollution, cigarette smoking, is the dominant cause of air pollution-induced disease. These factors minimize our potential for developing an adequate understanding of the health effects of vehicle and power plant emissions by studying only people. The alternative is to use the human data to the extent feasible and complement it with information gained in studies with macromolecules, organelles, cells, tissues and whole animals. Within this context, this paper reviews the use of inhalation studies with animals for defining human health risks of airborne materials, especially particulate materials. The major areas covered are: the fate of inhaled materials, the pathogenesis of disease induced by inhaled materials and long-term animal studies to identify late-occurring effects. Emphasis is placed on the utility of studies in whole animals as integrative models in which the multiple processes such as xenobiotic metabolism, cell injury, repair, transformation and promotion under the influence of many host factors interact in a manner that may not be directly observed in isolated cells or tissues.
Association of American Physicians.
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AMA Insights
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal