tbuckley/cabot-search huggingface dataset:
Hippocrates (460-375 BC)
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The economic impact of the first 10,000 cases of acquired immunodeficiency syndrome in the United States
Authors: A. M. Hardy
Journal: JAMA (1986)

Acquired immunodeficiency syndrome (AIDS) is a serious, fatal disease affecting a relatively young population and has a great economic impact. Expenditures for hospitalization and economic losses from disability and premature death were estimated for the first 10,000 patients with AIDS reported in the United States. Extrapolation of data from surveys done in New York City, Philadelphia, and San Francisco suggests that these 10,000 patients with AIDS will require an estimated 1.6 million days in the hospital, resulting in over $1.4 billion in expenditures. Losses incurred for the 8,387 years of work that will be lost from disability and from the premature death of the 10,000 patients will be over $4.8 billion. The total economic burden of the AIDS epidemic will continue to rise as the number of diagnosed cases increases. These estimates reinforce the need for effective disease prevention strategies to reduce the number of cases. (<i>JAMA</i>1986;255:209-211)
Contents
Authors: P Sharma, J Brill, M Canto, D Demarco, B Fennerty, N Gupta, L Laine, D Lieberman, C Lightdale, E Montgomery, R Odze, J Tokar, M Kochman, A Thrift, J Jones, G Kaplan, L Peyrin-Biroulet, L Baidoo, S Devlin, G Melmed, D Tanyingoh, L Raffals, P Irving, P Kozuch, M Sparrow, F Velayos, B Bressler, A Cheifetz, J.-F Colombel, C Siegel
Journal: Clinical Gastroenterology and Hepatology (2015)
Arteriogenesis in a rabbit hindlimb model can be accelerated by increased numbers of circulating blood monocytes Matthias Heil, Imo Hoefer, Niels van Royen, Ivo Buschmann, Wolfgang Schaper. Max-Planck-Institute for Physiol. &amp; Clin. Research, Bad Nauheim, Germany
Journal: Journal of the American College of Cardiology (2001)
Society Proceedings
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Portal hypertension in lymphoproliferative and myeloproliferative disorders: Hemodynamic and histological correlations
Authors: A Dubois
Journal: Hepatology (1993)

The pathogenesis of portal hypertension in patients with lymphoproliferative and myeloproliferative disorders is not fully understood. We investigated 20 patients with myeloproliferative disease and 47 patients with lymphoproliferative disease. Transvenous liver biopsies and hepatic vein pressure gradient measurements were performed in all patients, and portal vein blood flow was measured by pulsed Doppler sonography in 31 of these patients and in 22 normal volunteers. The hepatic vein pressure gradient was significantly higher in patients with hepatic infiltrates, fibrosis or both than in patients without hepatic lesions (8.3 ± 5.0 mm Hg vs. 4.1 ± 2.3 mm Hg; p < 0.01). Portal vein blood flow was significantly higher in patients with hematological disease than in normal volunteers (31.2 ± 15.5 ml/min · kg vs. 14.2 ± 4.6 ml/min · kg; p < 0.01). In 81.8% of patients with hepatic infiltrates, fibrosis or both and increased portal vein blood flow, the hepatic vein pressure gradient was greater than 6 mm Hg. Although we saw a significant correlation between splenic vein blood flow and portal vein blood flow (n = 20; p < 0.01), we found no significant correlation between splenic vein blood flow and hepatic vein pressure gradient or spleen size. Hepatic infiltration and fibrosis appear to be major determinants of increased hepatic vein pressure gradient, probably because they increase intrahepatic vascular resistance. The role of increased splenic blood flow is probably not determinant. However, because portal pressure was not measured directly in this study, the incidence of portal hypertension may have been underestimated. (HEPATOLOGY 1993;17:246–250.)
Erratum: International uniform response criteria for multiple myeloma
Authors: B G M Durie, J-L Harousseau, J S Miguel, J Bladé, B Barlogie, K Anderson, M Gertz, M Dimopoulos, J Westin, P Sonneveld, H Ludwig, G Gahrton, M Beksac, J Crowley, A Belch, M Boccadaro, I Turesson, D Joshua, D Vesole, R Kyle, R Alexanian, G Tricot, M Attal, G Merlini, R Powles, P Richardson, K Shimizu, P Tosi, G Morgan, S V Rajkumar
Journal: Leukemia (2007)
Increase in ornithine decarboxylase activity caused by hepatocyte growth factor in primary cultured adult rat hepatocytes
Authors: I Higaki
Journal: Hepatology (1993)

The effect of hepatocyte growth factor on ornithine decarboxylase activity was studied in primary cultured adult rat hepatocytes. Ornithine decarboxylase activity was increased 3 hr after the addition of hepatocyte growth factor and remained at a high level until 12 hr; thereafter it decreased, and it returned to the control level by 24 hr. Enzyme activity began to increase with 1 ng/ml hepatocyte growth factor and reached its maximum with 5 ng/ml hepatocyte growth factor. When insulin or epidermal growth factor was added with hepatocyte growth factor, enzyme activity was further stimulated. The level of ornithine decarboxylase messenger RNA did not increase with addition of hepatocyte growth factor. The half-time of ornithine decarboxylase activity was prolonged about twofold by hepatocyte growth factor treatment. These results suggest that hepatocyte growth factor treatment of cells enhanced ornithine decarboxylase activity posttranslationally (HEPATOLOGY 1993;17:99–102.)
Effects of anti-TNF? treatment on Crohn’s disease induced hepatic steatosis
Authors: Paul Peter Manka, Svenja Sydor, Ulrike von Arnim, Alexander Link, Ramiro Vilchez-Vargas, Annika Helbeck, Malte Brandenburg, Sonja Kinner, Yan Li, Ali Canbay, Alisan Kahraman, Heiner Wedemeyer, Lars Bechmann
Journal: Journal of Hepatology (2020)
Assessment of valvular heart disease with Doppler echocardiography
Authors: R. T. Lee
Journal: JAMA (1989)

The addition of Doppler principles to two-dimensional echocardiography has revolutionized the noninvasive evaluation of valvular heart disease. Doppler techniques allow precise measurements of blood flow velocity at different locations in the heart and great vessels, so that many aspects of hemodynamics can now be measured noninvasively. These techniques are particularly useful for the quantitative assessment of valvular stenosis; both valve areas and transvalvular gradients may be determined. Doppler echocardiography (particularly with color flow mapping) is also useful for the qualitative assessment of valvular regurgitation. By understanding the uses and limitations of Doppler echocardiography, physicians may now confidently follow up patients with mild or moderate valvular disease with serial noninvasive studies, avoiding the risks of cardiac catheterization in many patients. (<i>JAMA</i>. 1989;262:2131-2135)
Point Process Models in Asthma Attacks for Assessing Environmental Risk Factors
Authors: Toshinari Kamakura, Takemi Yanagimoto
Journal: Environmental Health Perspectives (1985)

Point process models are reviewed and discussed for assessing the effects of environmental risk factors on asthma attacks. It is pointed out that the logit model and proportional intensity model are useful for analyzing the data based on the diaries recorded consecutively during several months or during a few years. Some covariates that seems to influence upon asthmatics are explored using these models. Further work on estimating the smoothed base-line intensity function is briefly discussed in terms of the Bayes model.
Congenital virilizing adrenal hyperplasia without acceleration of growth or bone maturation
Authors: T. Aceto
Journal: JAMA (1966)

The simple form of congenital virilizing adrenal hyperplasia was seen in three girls, aged 21 months to 42 months. These children appear unique because they exhibited very mild virilization of the external genitalia and did not manifest acceleration of bone maturation. Posterior fusion of the labia majora obscured the vaginal orifice, resulting in the appearance of a urogenital sinus formation ("pseudourogenital" sinus). It was found that, until at least 4 years of age, girls untreated for this disorder are usually normal in height. Unless the clinician is aware that normal stature and bone age, and mildly abnormal genitalia, are compatible with congenital virilizing adrenal hyperplasia, patients with this disorder may not be properly treated.
Long-Term Residence in Areas of High Ozone: Associations with Respiratory Health in a Nationwide Sample of Nonsmoking Young Adults
Authors: Audrey Galizia, Patrick L. Kinney
Journal: Environmental Health Perspectives (1999)

Few studies have examined the respiratory effects of multiyear ozone exposures in human populations. We examined associations between current respiratory health status and long-term ozone exposure histories in 520 Yale College (New Haven, CT) students who never smoked. Questionnaires addressed current respiratory symptoms, respiratory disease history, residential history, and other factors. The symptoms of cough, phlegm, wheeze apart from colds, and a composite respiratory symptom index (RSI) were selected as outcome measures. Forced vital capacity (FVC), forced expiratory volume in 1 sec (FEV(1)), forced expiratory flow rate between 25 and 75% of FVC (FEF(25-75)), and forced expiratory flow rate at 75% of FVC (FEF(75)) were obtained by forced expiration into spirometers. Ozone exposure was treated as a dichotomous variable, where subjects were assigned to the high-exposure group if they lived for 4 or more years in a U.S. county with 10-year average summer-season daily 1-hr maximum ozone levels [greater/equal to] 80 ppb. Lung function and respiratory symptoms were analyzed by multiple linear and logistic regression on ozone exposure, controlling for covariates. Lung function was lower in the group with high ozone exposures: differences were statistically significant for FEV(1) [-3.1%; 95% confidence interval (CI), -0.2 to -5.9%] and FEF(25-75) (-8.1%; CI, -2.3 to -13.9%), and nearly so for FEF(75) (-6.7%; CI, 1.4 to -14.8). Gender-specific analyses revealed stronger associations for males than for females. The symptoms of chronic phlegm, wheeze apart from colds, and RSI were increased in the ozone-exposed group, with odds ratios of 1.79 (CI, 0.83-3.82), 1.97 (CI, 1.06-3.66), and 2.00 (CI, 1.15-3.46), respectively. We conclude that living for 4 or more years in regions of the country with high levels of ozone and related copollutants is associated with diminished lung function and more frequent reports of respiratory symptoms.
Neuropeptides, appetite regulation, and human obesity
Authors: J. F. Wilber
Journal: JAMA (1991)

<h3>SELECTED CASE</h3> A 55-YEAR-OLD married white woman presented with a 30-year history of progressive morbid obesity. Her birth weight was normal, at 3.8 kg. Her weight gain continued progressively, except for two self-induced remissions by means of severe restriction of energy intake (840 to 1680 J/d [1 cal = 4.2 J]). Her usual diet consisted of 18 900 to 21 000 J/d. Associated medical problems included choledocholithiasis, resulting in a cholecystectomy at age 29 years, and severe osteoarthritis involving both knees and the lower vertebral column. Meningitis with encephalitis occurred at age 3 years. The patient had normal urinary free cortisol (70 μg/d) and thyroid function test results. The patient was treated with moderate restriction of energy intake (decrease of 4000 J/d) without anorexigenic medications. She walked 3.3 km/d five times per week. Results of physical examination were as follows: blood pressure, 220/120 mm Hg in the left arm with a
Correlation of myocardial and renal necrosis with tissue electrolyte changes
Authors: D. Lehr
Journal: JAMA (1966)

It is known that degeneration and necrosis of tissue is associated with substantial changes in the electrolyte content of affected areas. It is not certain, however, whether such alterations are solely one of the consequences of tissue injury, or whether certain electrolyte shifts contribute to the elicitation of organic damage. In favor of a causative influence of electrolyte shifts, one may cite the fact that severe myocardial injury can be produced by dietary deficiency of potassium or magnesium, the two most important intracellular cations, and that the severity of cardiac lesions induced by dietary and other means can be enhanced by sodium-loading or by mineralocorticoids, and inhibited by the administration of potassium and magnesium salts. <h3>Primary Goals</h3> The primary goals of the present investigation were the following: (1) to search for possible similarities in the derangement of the electrolyte pattern occurring in myocardial necrosis produced by different means, (2) to
Editorial: Consultant crisis.
Journal: BMJ (1973)

Consultant CrisisThose barometers of professional opinion the correspondence columns have been registering a rising pressure of discontent among consultants for some time.One cause of this, in- adequate pay, has been about ever since the N.H.S. started, but this is not the only cause.The population's increasing demands on the N.H.S., the Service's chronic inability to project much of its working environment into the 20th century, and, more recently, the serious shortages of nurses and ancillary workers have all contributed to the consultants' difficulties.In addition they have watched-and in general welcomed-the junior staffs battling for improved working conditions, but inevitably this has increased their own load.So, despite a continuing expansion in the number of con- -sultants-551 were appointed in the U.K. in 1971-2, bringing the total on 30 September 1972 to 10,919-today too many consultants find themselves overworked, and their professional satisfaction dwindling.
Update: Implementation of a multidisciplinary quality improvement initiative to improve molecular testing rates in advanced non-squamous non-small cell lung cancer.
Authors: Zachary Otaibi, Amir Kamran, Gene Grant Finley, Richard White, Athanasios Colonias, Benny Weksler, Rodney E Wegner
Journal: Journal of Clinical Oncology (2019)

e18085 Background: EGFR mutations and ALK rearrangements are key targets in nonsquamous nonsmall cell lung carcinoma (nsNSCLC). Treatment with targeted therapy has been shown to improve progression-free survival and overall survival in many lung cancer patients. Current guidelines recommend evaluating all advanced nsNSCLC patients for these targets; however, previous work within our institution revealed that we were not testing a large segment of eligible patients. In order to improve testing rates, we utilized multidisciplinary meetings aimed at direct physician education and process/work-flow enhancement in order to improve our testing rates. We found a significant improvement in testing rates following this intervention, however, whether or not this improved rates were durable/sustainable was unclear. To determine whether this improvements were sustained we analyzed an additional two years of data from our registry. Methods: Utilizing the Association of Community Cancer Centers (ACCC) molecular testing framework, we launched a lean six sigma initiative aimed at improving our molecular profiling rates in 2014. A series of multidisciplinary meetings were conducted addressing key action items as outlined by the ACCC. Since this intervention, a total of 419 advanced nsNSCLC patients were identified from our tumor registry (2014-2017). Testing rates for EGFR and ALK were determined by individual chart review and compared to our previously published testing rates (2011-2013). Results: We found 81.1% (340/419) and 69.0% (289/419) of patients were tested for EGFR mutations and ALK rearrangements, respectively. We utilized a chi-square test of homogeneity to determine whether there was an increased EGFR and ALK testing rate post-intervention. Our EGFR testing rate increased 87.7%, from 43.2% (2011-2013) to 81.1% (2014-2017), p &lt; 0.00001, and our ALK testing rate increased 189.9%, from 23.8% (2011-2013) to 69.0% (2014-2017), p &lt; 0.00001. Further, the rates testing were comparable or even improved year-over-year post intervention indicating a sustained improvement following the quality improvement initiative. Conclusions: Multidisciplinary educational and process enhancement meetings help to improve molecular testing rates in nsNSCLC. In addition, the updated analysis suggests these improvements were durable year-over-year.
Hepatitis B in an Extended Family—Alabama
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
In Reply:
Authors: Dominik T. Schneider, Gabriele Calaminus, Ulrich Göbel
Journal: Journal of Clinical Oncology (2004)

of the Journal of Clinical Oncology article would benefit in knowing the mitotic activity data on the tumors associated with stage Ic disease and whether it was used to determine which patients would receive up-front adjuvant chemotherapy.A testable hypothesis is that mitotic activity defines the prognosis of children and adolescents with stage Ic ovarian sex cord-stromal tumors, rather than timing of tumor rupture.Ovarian sex-cord stromal tumors in children are rare and the controversy of how to best treat such patients has been poorly resolved in part because of the rarity of these tumors and the lack of prospective trials designed to assess the value of postoperative adjuvant chemotherapy. 5,6The efforts by the German Society of Pediatric Oncology and Hematology are therefore to be commended.However, the small subsets of patients studied, the lack of information pertaining to the tumor mitotic status, and the lack of further explanations as to why certain patients were selected to receive postoperative chemotherapy while other patients with apparently similar presentations were not warrants caution in interpreting the role of timing of tumor rupture in guiding the management of patients with stage Ic ovarian sex-cord stromal tumors.We look forward to clarification from the authors on these important points.
Developments like major resection bone allografts foster progress in tissue-banking technology
Authors: T. F. Kirn
Journal: JAMA (1987)

SIXTEEN YEARS AGO, Henry Mankin, MD, removed the entire distal segment of the femur from a woman who had a giant cell tumor and replaced it with a section of cadaveric bone. Today, Mankin says, the patient has a functioning leg and is still doing well. Major resection bone allografting, which can involve replacing all or part of a joint and suturing the tendons and ligaments together, is one example of a medical development that is increasing the need for human tissue and fostering progress in tissue-banking technology. Mankin, a professor of orthopedic surgery at Harvard Medical School, Boston, says allografting of skeletal parts has had a long, but "slightly tarnished," history—stretching back almost 100 years. Ending years of frustrating failure was the discovery, in the 1950s, that freezing the bone prior to transplantation reduced the immune reaction presumably responsible for the large number of failures. Bone allografting in general
Hepatitis C therapy with grazoprevir/elbasvir and glecaprevir/ pibrentasvir in patients with advanced chronic kidney disease - data from the German hepatitis C-registry (DHC-R)
Authors: Kerstin Stein, Albrecht Stoehr, Hartwig Klinker, Gerlinde Teuber, Uwe Naumann, Christine John, Renate Heyne, Yvonne Serfert, Claus Niederau, Stefan Zeuzem, Thomas Berg, Johannes Wiegand, German Hepatitis C-Registry
Journal: Journal of Hepatology (2020)
Correction: Scandinavian and Dutch lessons in childhood road traffic accident prevention
Journal: BMJ (1982)

produces a stigma which, if it arises in childhood, must be dealt with by the family.The approach adopted and its course depend on the nature of the stigma.For example, social development might be delayed or even impaired by mental retardation, altering the possible ways for the family to react.Again, when the handicap is particularly severe, the individual might not be expected to achieve independence from his family, who therefore have greater difficulty reaching the courtesy stigma stage.Parental reactions might be expected to be quite different if the stigma becomes apparent initially some time after birth.No specific mention has been made of the management of