tbuckley/cabot-search huggingface dataset:
Polaris. The Story of an Eskimo Dog.
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE THERAPEUTIC USE OF NITROGEN MUSTARDS
Authors: P. W. C.
Journal: Annals of Internal Medicine (1947)

Editorial1 October 1947THE THERAPEUTIC USE OF NITROGEN MUSTARDSP. W. C.P. W. C.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-27-4-641 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe sulfur and nitrogen mustards, because of their use as warfare agents, have been subjected to intensive study, both as to their chemical nature and their action on the tissues. Although originally employed primarily because of their local irritant and vesicant action on the skin and mucous membranes, it was soon recognized that when absorbed they exert a toxic action on a variety of tissues.In animals subjected to toxic doses,1the tissues most severely involved are the mucosa of the gastrointestinal tract and the hemopoietic tissues. There is vacuolization and swelling of the nuclei of the gastrointestinal epithelium, followed...1 GILMANPHILLIPS AFS: The biological actions and therapeutic applications of the B-chloroethyl amines and sulfides, Science, 1946, ciii, 409-415. CrossrefGoogle Scholar2 GOODMAN LS: Nitrogen mustard therapy, Jr. Am. Med. Assoc., 1946, cxxxii, 126-132. CrossrefGoogle Scholar3 JACOBSON LO: Nitrogen mustard therapy, Jr. Am. Med. Assoc., 1946, cxxxii, 263-271. CrossrefGoogle Scholar4 APTHOMASCULLUMBINE MIH: Nitrogen mustards in Hodgkin's disease, Lancet, 1947, i, 899-901. CrossrefGoogle Scholar5 RHOADS CP: Nitrogen mustards in the treatment of neoplastic disease, Jr. Am. Med. Assoc., 1946, cxxxi, 656-658. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDermatology 1 October 1947Volume 27, Issue 4Page: 641-645KeywordsEpitheliumGastrointestinal tractInflammationMucous membranes Issue Published: 1 October 1947 PDF downloadLoading ...
Fluid Levels in Emphysematous Bullae
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medical Team Seeks to Identify Human Remains From Mass Graves of War in Former Yugoslavia
Authors: Phil Gunby
Journal: JAMA (1994)

DESPITE DISCOURAGING developments in the former Yugoslavia, physicians with ties to that troubled land continue to do what they can. One of those is Dragan Primorac, MD, a native of Split on the Adriatic Sea coast of Croatia, which declared its independence from the former Yugoslavian federal union 41 months ago and has suffered numerous casualties in subsequent fighting (<i>JAMA</i>. 1993;270:626-628). Primorac currently is part of the faculty of the Department of Pediatrics, University of Connecticut Health Center, Farmington, studying DNA, RNA, and proteins as part of a study of osteogenesis imperfecta. During the coming year, Primorac and his colleagues will be resuming their efforts to identify the remains of 26 of 61 persons found in six mass graves in a neighboring republic. The site is Kupres in Bosnia and Herzegovina, which— nearly 8 months after Croatia's July 25, 1991, declaration—in turn declared its independence March 6, 1992, and since
Cancer of the head and neck. Oropharynx
Authors: P. Rubin
Journal: JAMA (1971)

The malignant gradient increases as the origin of cancers moves posteriorly in the oral cavity and reaches the oropharynx (Fig 1, Fig 2, Table 1). Thus, cancers of the base of the tongue tend to be more extensive (60% to 70% are T3 and T4) and more aggressive than cancers in the oral portion of the tongue.<sup>2</sup>The same is true of cancers of the tonsillar region as compared to those of the buccal mucosa or alveolar ridge. The incidence of metastatic neck disease is higher (more than 50% on admission). Bilateral and contralateral presentation increases in oropharyngeal primaries because of the richer network of lymphatics. The histological features are more aggressive; cancer in the oropharynx is undifferentiated and anaplastic in contrast to the more differentiated cancers of the mouth. Cure rates are very poor when one considers the more common incidence of this disease in older age groups,
Abstract 18526: Electrogram Amplitude is Reduced at Rotor Sites Critical to Maintenance of Human Persistent Atrial Fibrillation
Authors: Junaid A Zaman, Gautam G Lalani, Tina Baykaner, Shirley Park, David E Krummen, Paul J Wang, Sanjiv M Narayan
Journal: Circulation (2015)

Introduction: Increasing studies find human AF is driven by rotors, but their detection remains challenging. Theoretically, rotor cores display low amplitude and multiphasic signals, but human AF rotors fail to display such signatures. This may reflect rotor precession (obscuring analysis site chosen), poor basket contact or bipoles (that do not register orthogonal wavefronts). We hypothesized that studying unipolar signals at rotor precession areas may reveal hitherto hidden electrogram signatures. Methods: We studied 22 persistent AF patients (60±11 years, CHADS2=1.9), in whom phase mapping of 64 pole basket signals revealed rotors/sources where ablation terminated AF (fig A). Unipolar electrograms over the rotor precession area were measured by 3 blinded observers for spectral dominant frequency (DF), peak-to-peak amplitude and duration. This was compared to a paired source in each patient where ablation did not terminate AF (‘controls’) (fig B). Results: Patients had 3.3±1.7 AF rotor/focal sources. At the index source, AF terminated to sinus rhythm (n=14) or atrial tachycardia by targeted ablation (mean 4.0 mins). Compared to control areas, AF sustaining rotors/sources had lower amplitude (fig C) (0.60±0.30mV vs. 0.87±0.70mV, p=0.02). Conversely, electrogram spectra (90±45Hz vs. 80±46Hz, p=ns), duration (125±45ms vs. 116±47ms, p=ns) and AF cycle length (174±8ms vs. 174±6ms, p=ns) did not differ. Conclusions: Rotors/sources that maintain human persistent AF have lower unipolar amplitude than non-termination sites. This is the first identified electrogram signature for functionally critical human AF rotors, and motivates definition of structure/function correlations at these sites.
IMPROVED RECIPROCAL RELATIONS OF PHYSICIANS AND PHARMACISTS.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Comparison between Ketotifen and DSCG in bronchial challenge Pauwels, R., Lamont, H., and VanDerStraeten, M.: Clin. Allergy 8:289, 1978
Authors: Murray Albert Brooklyn, Bernard Siegel Brooklyn, N Friedman, C/E\&& Ohio, David Stein, Spring Valley, N Monroe, Coleman Stamford, Walzer Eugene, N Sheldon Berger Freehold, Ossining Neil Goldman
Journal: Journal of Allergy and Clinical Immunology (1978)
Treatment of Hiccups by Pharyngeal Stimulation in Anesthetized and Conscious Subjects
Authors: M. Ramez Salem
Journal: JAMA (1967)

Stimulation of the pharynx with a catheter introduced through the nose appears to be a valuable method for managing hiccups in conscious and anesthetized man. Immediate inhibition of hiccups occurred in 84 of 85 patients treated in this manner, of whom 65 were anesthetized. Hiccups recurred in some patients, but were successfully managed with the same maneuver. The area responding to stimulation is the middle of the pharynx, opposite the body of the second cervical vertebra, which is innervated by the pharyngeal plexus. The suggested mechanism of action is impulses arising in response to pharyngeal stimulation which may block or inhibit afferent impulses being transmitted through the vagi thus interrupting the hiccup reflex. No undesirable effects have been encountered as a result of pharyngeal stimulation.
Styx
Authors: Ronald Pies
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Research Needs for Hepatic Injury Due to Environmental Agents
Authors: Philip S. Guzelian
Journal: Environmental Health Perspectives (1983)

This report presents an overview of the patterns of liver injury produced by presently recognized toxic substances in the environment. Current concepts of the metabolic disposition of these substances in the liver suggest that their toxic effects may be modulated by an interplay between enzymatic pathways for activation or inactivation of foreign compounds. A better understanding of the genetic control of the enzymes involved in these pathways, as well as the mechanisms of cell death or malignancy produced by the products of these pathways, is needed. Although a number of sensitive biochemical tests of liver function are currently available, development of specific, noninvasive screening tests for the earliest manifestations of liver injury are urgently needed.
Maternal Hepatitis B Screening Practices—California, Connecticut, Kansas, and United States, 1992-1993
Journal: JAMA (1994)

Each year in the United States, an estimated 22,000 infants are born to women with chronic hepatitis B virus (HBV) infection. These infants are at high risk for perinatal HBV infection and chronic liver disease as adults. The American College of Obstetrics and Gynecology, the American Academy of Pediatrics, the American Academy of Family Practice, and the Advisory Committee on Immunization Practices each have recommended that all pregnant women be routinely tested for hepatitis B surface antigen (HBsAg) during an early prenatal visit in each pregnancy to identify newborns who require immunoprophylaxis for the prevention of perinatal HBV infection (1-4). To evaluate progress in implementing this recommendation, surveys were conducted to assess the effectiveness of maternal HBsAg screening in three states--California, Connecticut, and Kansas--and a sample of hospitals in the United States.
Safeguarding the Special Senses.
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Infographic: AMSSM position statement on cardiovascular preparticipation screening in athletes: Current evidence, knowledge gaps, recommendations and future directions
Authors: Jonathan A Drezner, Francis G O'Connor, Kimberly G Harmon, Karl B Fields, Chad A Asplund, Irfan M Asif, David E Price, Robert J Dimeff, David T Bernhardt, William O Roberts
Journal: British Journal of Sports Medicine (2016)
Decision Making in Normal and Pathological Families
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Habituation and urinary retention
Authors: J. L. Jammes
Journal: JAMA (1975)

Four subjects with partial or episodic complete urinary retention and bladder hypotonicity with large urinary residuals underwent "habituation" treatment. Results indicated an exponential decrease in urinary residuals to 0 ml and disappearance of partial or complete urinary retention within 20 weeks. This study is presented as an example of how conditioning therapy may be applied to the treatment of certain neurological disorders. (<i>JAMA</i>232:1264-1266, 1975)
Intracardiac Surgery
Authors: T. H. Sellors
Journal: BMJ (1955)

The interior of the heart is one of the last recesses in the body to be explored by the surgeon, and it is only in very recent years that intracardiac operations have had any practical application in the treatment of cardio- vascular disease.The magnificent isolated endeavours of Souttar, Duval, Doyen, and Tuffier belong to the realm of surgical history, but little was achieved until the forces of war accelerated the development of this particular branch, which otherwise would.have pro- gressed much more slowly.The achievement of Dwight Harken, who successfully removed 14 missiles from the heart itself, can be regarded as an example of the type of impetus that heart surgery received, and at the same time there was the corresponding evolution of the sur- gery of great vessels, whose technique has much in com- mon with intracardiac work.The practical foundation for this branch lay as much as anything in the hands of thoracic surgeons and anaesthetists who were accus- tomed to perform thoracotomy and to manage its after- treatment, and, indeed, in Great Britain heart surgery is chiefly carried out by thoracic surgeons rather than by specialists in the cardiovascular system.Apart from actual technique, the success of intracardiac surgery depends on detailed hnd careful pre-operative assessment and the most careful post-operative manage- ment.In addition, special measures have to be employed in treating some forms of cardiac defects.I refer to hypothermia and to extracorporeal heart-lung methods.My own experience in these methods has been limited to cooling techniques, which have met the situation adequately.Either method or a combination of both enables the heart to be excluded from the normal circulation for a period of 10 to 15 minutes, thus allowing the surgeon to make a deliberate incision into the heart and to repair defects or abnormalities under direct vision.At the present time publicity is directed more towards the successes of such operations than towards the failures, and there still remain a number of problems to be solved before these procedures can have a widespread application.
PRACTICAL AIDS IN THE DIAGNOSIS OF PERICARDIAL EFFUSIONS, IN CONNECTION WITH THE QUESTION AS TO SURGICAL TREATMENT.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Asthma
Authors: Robert F. Lemanske
Journal: JAMA (1997)

For unknown reasons, the morbidity and mortality from asthma are increasing in many parts of the world, making it a global health concern. The heterogeneous nature of the clinical manifestations and therapeutic responses of asthma in both adult and pediatric patients indicate that it may be more of a syndrome rather than a specific disease entity. Numerous factors, including viral infections, allergen and irritant exposure, and exercise, among others, complicate both the short- and long-term management of asthma. Therapeutic intervention has focused on the appreciation that airway obstruction in asthma consists of bronchial smooth muscle spasm and variable degrees of airway inflammation characterized by edema, mucous secretion, and the influx of a variety of inflammatory cells. Choosing appropriate medications depends on the disease severity (intermittent, mild persistent, moderate persistent, severe persistent), patterns of disease activity (exacerbations related to viruses, allergens, exercise, etc), and the age at onset (infancy, childhood, adulthood).
THE BASAL METABOLISM IN FEVER
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal