tbuckley/cabot-search huggingface dataset:
Human Diploid Cell Rabies Vaccine
Authors: Kenneth W. Bernard
Journal: JAMA (1982)

To determine antibody responses to small doses of human diploid cell rabies vaccine (HDCV), we determined rabies antibody titers in 124 volunteers who had been vaccinated with one of five primary preexposure regimens. In a sixth group of 47 persons previously vaccinated with duck embryo rabies vaccine (DEV), we evaluated the booster response after a 0.1-mL dose of intradermal (ID) HDCV. Persons in all five groups undergoing primary immunization received three doses of vaccine, one each on days 0, 7, and 28. The dose and route of vaccination for the five groups included 1 mL intramuscular (IM), 0.1 mL ID (two subgroups), 0.1 mL subcutaneous (SC), and 0.25 mL SC. Adequate titers developed in all persons, irrespective of the route or quantity of vaccine. The geometric mean titers (IU/mL) on day 49 in those receiving primary regimens were 12.87 (1.0 mL IM), 7.44 (0.1 mL ID by syringe), 3.05 (0.1 mL by jet injector), 3.17 (0.1 mL SC), and 6.47 (0.25 mL SC). Titers on day 90, while lower, were still acceptable. Adequate antibody titers developed in all persons previously vaccinated with DEV after a single 0.1-mL ID dose of HDCV; however, higher titers developed at day 7 in those who had shown an adequate response to DEV in the past. Results of this study suggest that HDCV may be used ID or SC for primary preexposure rabies prophylaxis and ID for booster immunization. (<i>JAMA</i>1982;247:1138-1142)
THE ELIMINATION OF IRON AND ITS DISTRIBUTION IN THE LIVER AND SPLEEN IN EXPERIMENTAL ANEMIA
Authors: Harry Dubin, Richard M. Pearce
Journal: The Journal of Experimental Medicine (1917)

Blood destruction due to a single injury, as by sodium oleate, or acting through a short period of time, as by toluylenediamine or hemolytic immune serum, is not characterized, in the absence of hemoglobinuria, by an increased elimination of iron in the urine. This holds, not only for the evanescent injury caused by sodium oleate, but also for the severe type caused by hemolytic immune serum, in which a progressive destruction of the blood may persist for 2 weeks or more with constant evidence of the disintegration of erythrocytes as shown by bile pigment in the urine. This finding is in accord with previous investigations of anemia in both man and animals. Likewise, no striking increase is evident, under such circumstances, in the percentage of iron excreted in the feces. The total amount of iron in the feces has been notably increased in two experiments with hemolytic serum, but as the percentage was not appreciably altered, the difference depends presumably on variations in the bulk of feces rather than upon increased elimination. This evidence of the power of the body to conserve the iron rephagocytosis is negligible, is to be fragmented one by one, while still circulating, to a fine, hemoglobin-containing dust. The cell fragments are rapidly removed from the blood, but their ultimate fate remains to be determined. The facts indicate that they are removed from the blood by the spleen, and under exceptional conditions, by the bone marrow.
Adrenoleukodystrophy
Authors: P. W. Ladenson
Journal: JAMA (1989)

<h3>CASE PRESENTATION</h3> —Howard Baum, MD A 35-YEAR-OLD white man with known primary adrenal insufficiency presented to the endocrinology clinic complaining of clumsiness in the legs. The patient was well until age 19 years, when he experienced three episodes of fever, nausea, vomiting, diarrhea, and extreme fatigue, each more severe than the previous. On the third occasion, the diagnosis of adrenal insufficiency was made based on low serum cortisol levels before and after corticotropin stimulation. Daily oral adrenal steroid replacement therapy was begun. The patient generally was well in subsequent years, increasing his dose of cortisone acetate when suffering an intercurrent illness. He remained tan throughout the year. Several months before this presentation the patient noted clumsiness in his lower extremities. His athletic ability, while never outstanding, declined. He noticed stiffness in the legs after prolonged sitting and commented that there was diminished sensation in the feet. There was no weakness
Massive retroperitoneal hemorrhage with unusual presentation
Authors: P. E. Palmer
Journal: JAMA (1974)

RETROPERITONEAL hemorrhage after blunt trauma, presenting uniquely as a strangulated inguinal hernia, has been reported.<sup>1</sup>A second case with similar presentation, but of nontraumatic origin, is described here. <h3>Report of a Case</h3> A 63-year-old man was admitted to the emergency room, complaining of acute pain in the left groin and of left-lower-quadrant "intestinal" pain. The pain, of sudden onset, was sharp, continuous, and without radiation. Also noted was an increasingly painful, tender mass in the left groin. The patient felt weak and dizzy, but he showed no other specific symptoms. He gave an eight-year history of treated hypertension (most recent blood pressure, 180/110 mm Hg), and of hospitalization for acute myocardial infarction six months before his present admission. His recovery was satisfactory, but angina pectoris had appeared during the previous three months. On arrival, his blood pressure was 104/76 mm Hg. Shortly thereafter, a syncopal episode occurred, lasting 15
Rewarding Cancer Research
Journal: Environmental Health Perspectives (1996)

Need Basic ResearchDissection of direct immune-endocrine interactions Understanding of cellular and molecular mechanisms Sensitive, inexpensive, and widely available analytical tools Understanding the biological significance of subtle low-dose effects Identify and characterize critical windows of susceptibility across species Characterize source of population heterogeneity in dose responsiveness (age, gender, nutrition, etc.) Exposure Determination Rapid and inexpensive Xposure moitorng ithods for use in wildlf populatns Increased moniong efots to id if stats ndtrends Of EDs Environmental causes of liver, brain, and lung cancers MixturesResearch to address the additivity principle for mixtures In vitro and in vivo studies of complex mixtures to evaluate validity of TEQsIdentification and testing of environmentally relevant mixtures Systematic evaluation of species, cellular, and age dependent response to mixtures of EDs
AN AUTOMATIC METHOD FOR SERIAL BLOOD PRESSURE OBSERVATION IN MAN
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Instrumentation in positron emission tomography. Council on Scientific Affairs. Report of the Positron Emission Tomography Panel
Authors: George M. Bohigian, E. Harvey Estes, Ira R. Friedlander, William R. Kennedy, John H. Moxley, Patricia J. Numann, Paul S. Salva, William C. Scott, Joseph H. Skom, Richard M. Steinhilber, Jack P. Strong, Henry N. Wagner, William R. Hendee, William T. McGivney, Joanna S. Fowler, Edward J. Hoffman, Steven M. Larson, Heinrich R. Schelbert, Markus Schwaiger, Alfred Wolf
Journal: JAMA (1988)

Positron emission tomography (PET) is a three-dimensional medical imaging technique that noninvasively measures the concentration of radiopharmaceuticals in the body that are labeled with positron emitters. With the proper compounds, PET can be used to measure metabolism, blood flow, or other physiological values in vivo. The technique is based on the physics of positron annihilation and detection and the mathematical formulations developed for x-ray computed tomography. Modern PET systems can provide three-dimensional images of the brain, the heart, and other internal organs with resolutions on the order of 4 to 6 mm. With the selectivity provided by a choice of injected compounds, PET has the power to provide unique diagnostic information that is not available with any other imaging modality. This is the first of five reports on the nature and uses of PET that have been prepared for the American Medical Association's Council on Scientific Affairs by an authoritative panel. (<i>JAMA</i>1988;259:1531-1536)
Abstract 1680: RhoGAP and PAP2 domain-containing fusions are recurrent and prognostic in gastric cancer
Authors: Hark K. Kim
Journal: Cancer Research (2019)

Abstract We conducted an RNA sequencing study to identify novel in-frame gene fusions in 80 discovery dataset tumors collected from young Korean patients with diffuse gastric cancer. Twenty-five in-frame fusions were associated with diffuse gastric cancer, three of which (CLDN18-ARHGAP26, CTNND1-ARHGAP26, and ANXA2-MYO9A) were recurrent in 384 diffuse gastric cancers based on RT-PCR. All three fusions contained a RhoGAP domain in their 3’ partner genes. Patients with one of these three RhoGAP domain fusions had a significantly worse prognosis than those without such fusions. The median survival was 29.1 [95% CI, 5.7–not reached] and 94.6 [95% CI, 62.0–not reached] months, respectively (P=0.011, log-rank; HR, 2.8 [95% CI, 1.5–5.3]). Ectopic expression of CLDN18-ARHGAP26 promoted the migration and invasion capacities of diffuse gastric cancer cells. Parallel targeted RNA sequencing analysis additionally identified PAP2 domain-containing fusions as recurrent and poor prognostic in-frame fusions. Overall, in-frame gene fusions containing either RhoGAP or PAP2 domain clearly defined the aggressive subset (7.5%) of diffuse gastric cancer, and their prognostic impact (HR, 3.4 [95% CI, 2.0–5.7]) was greater than, and independent of, chromosomal instability and CDH1mutations. Our study may provide novel genomic insights guiding future strategies for managing diffuse gastric cancer. Citation Format: Hark K. Kim. RhoGAP and PAP2 domain-containing fusions are recurrent and prognostic in gastric cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1680.
Clinical Radiology
Authors: Yolanda T. Adler
Journal: JAMA (1984)

Basically, radiology involves the understanding of the gross changes produced by a disease entity as identified radiologically. Shadows on film can only be interpreted through knowledge of those changes. Any book on "clinical radiology" must continuously use pathology and pathophysiology as references and it is easy to stray through classifications, pathological descriptions, and reviews of evolution of disease. This avalanche of information tends to create some clutter. The fault is in the subject, and the work cannot escape this problem. Despite this, the need for students to acquire some fundamentals justifies this book, written for "clinical students and for postgraduates engaged in hospital practice or preparing for higher qualifications in medicine or surgery." It is well organized and the layout convenient, with most roentgenograms close to the text they illustrate. The reproductions are of excellent quality and the films chosen tend to be typical, representative, and obvious. The emphasis is
Negative Results
Authors: Robert S. Schwab
Journal: JAMA (1962)

<h3>To the Editor:—</h3> The July 7 issue ofThe Journal(<b>181</b>:41) introduced the new department of Negative Results. I would like to congratulate you on the formulation and incorporation of this section. There is a tremendous need for these important communications involving negative results in drug administration and other forms of therapy, as well as in some clinical investigations of symptoms and signs. As you stated in the introductory editorial, a great many people are reluctant to go to the trouble of publishing negative results. They feel, as you indicated, thatThe Journalis not interested in such papers and that readers would hesitate to peruse the details in a long paper covering such material. Therefore, I think it is very wise that this important section is to appear in a brief form. After a few years, you may very well accumulate some most important data which will certainly
Direct Anastomosis Suggested For Traumatic Aneurysm of Aorta
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Serum Cholesterol
Authors: Alvan L. Barach
Journal: JAMA (1976)

<h3>To the Editor.—</h3> In the commentary "Correct Levels of Serum Cholesterol" (236:261, 1976), Irving Wright mentions cholesterol studies of the American Heart Association in which the "participants whose values were higher in the fourth and fifth quintiles have an increased risk of premature coronary heart disease." However, D. S. Frederickson has recently stated that people more than 55 years of age are<i>not</i>adversely affected by a diet which includes food with cholesterol, either in the incidence of coronary thrombosis or its complications.<sup>1</sup> Since Dr Frederickson is among the acknowledged experts in lipoid metabolism, his opinion should be publicized. The advice to limit ingestion of animal fat is more properly restricted to our youth and younger adults, who are apt to benefit from reducing their serum cholesterol to the 170 to 240 mg/100 ml range. Older people are more vulnerable to prohibitions. As Francis Bacon said: "They adventure too
Correction: Late onset asthma
Authors: Jonathan Thow
Journal: BMJ (1990)

cannot definitely be recommended despite the carrot of a more physiological action profile.Apart from the practical problems of assessing the depth of subcutaneous tissue in a large number of patients-and the provision of a range of needle lengths-longer term studies are needed on blood glucose control, the relative rate of hypoglycaemia, effects of exercise, and patient acceptability.Until such data are available it may perhaps be wise to recommend that soluble insulin is also injected at an angle into a skin fold or to provide shorter needles of 3-5 mm.
Structure-Activity Correlations for Interactions of Bicyclophosphorus Esters and Some Polychlorocycloalkane and Pyrethroid Insecticides with the Brain-Specific t-Butylbicyclophosphorothionate Receptor
Authors: John E. Casida, Lowell J. Lawrence
Journal: Environmental Health Perspectives (1985)

[35S]t-Butylbicyclophosphorothionate or [35S]TBPS is an improved radioligand for the picrotoxinin binding site in rat brain synaptic membranes. The toxic isomers of the hexachlorocyclohexanes, polychlorobornanes, and chlorinated cyclodienes displace [35S]TBPS with a stereospecificity and potency generally correlated with their mammalian toxicity. In a few cases this correlation is improved by correction for metabolic activation or detoxification on using a coupled brain receptor/liver microsomal oxidase system. The alpha-cyano-3-phenoxybenzyl pyrethroids, although less potent, inhibit [35S]TBPS binding in a stereospecific manner correlated with their toxicity. Scatchard analyses indicate that these three classes of polychlorocycloalkane insecticides act at the TBPS binding site within the gamma-aminobutyric acid (GABA) receptor-ionophore complex whereas the alpha-cyano pyrethroids interact with a closely associated site. These insecticides and TBPS analogs may serve as useful probes further to elucidate the topography of the TBPS binding site and its relationship to the chloride channel.
Endocrinology, Philadelphia
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An Improved Artificial Kidney
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Widened Septum Pellucidum in Hemispheric Gliomas
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Roman-Gomez J, Jiminez-Velasco A, Castillejo JA, Agirre X, Barrios M, Navarro G, Molina FJ, Calasanz MJ, Prosper F, Heiniger A, Torres A. Promoter hypermethylation of cancer-related genes: a strong independent prognostic factor in acute lymphoblastic leukemia. Blood. 2004;104:2492-2498.
Journal: Blood (2009)
Fresh-Water Biology.
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CONJUGATE DEVIATION OF THE EYES AND HEAD AND DISORDERS OF THE ASSOCIATED OCULAR MOVEMENTSIN TUMORS AND OTHER LESIONS OF THE CEREBRUM.
Authors: T. H. WEISENBURG
Journal: JAMA (1907)

<h3>AUTHOR'S CASES OF CONJUGATE DEVIATION OF THE EYE AND HEAD.</h3><h3>Case 1.</h3> —McL., a woman, aged 60, was admitted to the Philadelphia General Hospital, March 13, 1905, to the service of Dr. Spiller from the out-wards, with a history of a stroke of one day's duration, in the left side. <h3>Examination.</h3> —The tendon reflexes of the upper limbs seemed to be absent. In the lower limbs the patellar and Achilles jerks were increased, more on the left side, and the Babinski sign was present on this side. Sensation for touch and pin prick was normal. The patient was not wholly unconscious and could respond to questions and would obey commands. A sweetish, urinous odor which suggested a uremic condition was present. The pupils were equal and larger than normal, and the response to light was sluggish on both sides. She could not be tested for accommodation and convergence, and ocular
Reply from the Authors
Authors: Casper P. Bots, Henk S. Brand, Enno C.I. Veerman, Marianne Valentijn-Benz, Barbara M. Van Amerongen, Robert M. Valentijn, Joost A. Bijlsma, Pieter D. Bezemer, Piet M. Ter Wee, Arie V. Nieuw
Journal: Kidney International (2005)