tbuckley/cabot-search huggingface dataset:
Serological response to rubella revaccination
Authors: M. K. Serdula
Journal: JAMA (1984)

To document the serological response, 21 seronegative rubella vaccinees (hemagglutination inhibition [HI] titer &lt;10) were revaccinated with RA 27/3 rubella vaccine. All demonstrated an anamnestic response. Although RA 27/3 vaccine was an effective booster, antibody boost was not maintained in some persons. Of 15 persons tested, 24 to 27 months after revaccination, six had a significant HI antibody drop (fourfold or greater); only one had lost all detectable HI antibody. Although all 21 study participants were initially HI seronegative by rubella HI testing, 16 (76.2%) possessed neutralization and/or enzyme-linked immunosorbent assay antibodies before revaccination. As more persons with vaccine-induced immunity join the adult population pool, more sensitive test methods may be needed to assess serological status accurately. (<i>JAMA</i>1984;251:1974-1977)
Osteoclast-Mediated Bone Resorption Is Stimulated During Short-Term Administration of Granulocyte Colony-Stimulating Factor But Is Not Responsible for Hematopoietic Progenitor Cell Mobilization
Authors: Yasushi Takamatsu, Paul J. Simmons, Robert J. Moore, Howard A. Morris, Luen B. To, Jean-Pierre Lévesque
Journal: Blood (1998)
Highlights
Journal: JAMA (2019)

Continuing Olanzapine for Psychotic Depression in Remission 622Combined pharmacotherapy for major depressive disorder with psychotic features includes antidepressant and antipsychotic medications, but it is unclear whether patients in remission should discontinue antipsychotic treatment to avoid serious adverse drug-related events.Flint and colleagues for the STOP-PD II Study Group randomized 126 patients in remission for an episode of psychotic depression treated with sertraline plus olanzapine and found that continuing combined therapy vs treatment with sertraline alone reduced the risk of relapse over 36 weeks.In an Editorial, Coryell discusses the long-term clinical management of patients with psychotic depression.
Prognostic markers for the response to inferferon-alpha treatment in chronic hepatitis C . Virchow Hospital, Dept. of Internal Medicine, Humboldt University, Berlin, Germany
Journal: Hepatology (1995)

The separation and characterization of unconjugated and conjugated bile acid 3-glucuronides in biological fluids without prior deconjugation by high-performance liquid chromatography (HPLC) are described. A urine sample from a patient with obstructive jaundice was passed through a Sep-Pak C18 cartridge and was separated into groups by ionexchange chromatography on a lipophilic gel, piperidinohydroxypropyl Sephadex LH-20, providing the glucuronide fraction. Subsequent resolution into individual 3-glucuronides was attained by HPLC on μBondapak C18 and Shodex ODS Pak F-411 columns. The 3-glucuronides of cholate, deoxycholate, chenodeoxycholate, glycocholate, glycochenodeoxycholate and taurochenodeoxycholate were identified on the basis of their behaviour in HPLC using mobile phases of different pH. The enzymatic hydrolysis of these glucuronides and derivatization of deconjugated bile acids with 1-anthroyl nitrile followed by chromatographic separation on a Cosmosil 5C18 column with fluorescence detection were carried out for unequivocal characterization. The ratio of unconjugated, glyco- and tauro-conjugated bile acid 3-glucuronides excreted in urine was found to be ca. 2:3:1.
Separation of Mycotoxin-Containing Sources in Grain Dust and Determination of Their Mycotoxin Potential
Authors: Muriel S. Palmgren, Louise S. Lee
Journal: Environmental Health Perspectives (1986)

Two distinct reservoirs of mycotoxins exist in fungal-infected cereal grains--the fungal spores and the spore-free mycelium-substrate matrix. Many fungal spores are of respirable size and the mycelium-substrate matrix can be pulverized to form particles of respirable size during routine handling of grain. In order to determine the contribution of each source to the level of mycotoxin contamination of dust, we developed techniques to harvest and separate mycelium-substrate matrices from spores of fungi. Conventional quantitative chromatographic analyses of separated materials indicated that aflatoxin from Aspergillus parasiticus, norsolorinic acid from a mutant of A. parasiticus, and secalonic acid D from Penicillium oxalicum were concentrated in the mycelium-substrate matrices and not in the spores. In contrast, spores of Aspergillus niger and Aspergillus fumigatus contained significant concentrations of aurasperone C and fumigaclavine C, respectively; only negligible amounts of the toxins were detected in the mycelium-substrate matrices of these two fungi.
A phase III trial to compare efficacy and safety of lenvatinib in combination with everolimus or pembrolizumab vs sunitinib alone in first-line treatment of patients (Pts) with metastatic renal cell carcinoma (RCC).
Authors: Robert J. Motzer, Viktor Grünwald, Thomas E. Hutson, Camillo Porta, Thomas Powles, Masatoshi Eto, Corina E Dutcus, Mahadi Ali Baig, Lea Dutta, Di Li, Toni K. Choueiri
Journal: Journal of Clinical Oncology (2017)

TPS4595 Background: Lenvatinib (LEN) is a multikinase inhibitor of vascular endothelial growth factor (VEGF) receptor 1–3, fibroblast growth factor receptor 1–4, platelet-derived growth factor receptor alpha, and RET and KIT. Based on a phase 2 study (Motzer et al. Lancet Oncol 2015), LEN was approved in combination with everolimus (EVE) for treatment of metastatic RCC following 1 prior VEGF-targeted therapy. A phase 1b/2 study of LEN in combination with pembrolizumab (PEM) in pts with RCC LEN is also underway. We report the design of a multicenter, open-label, phase 3 trial of LEN plus EVE or PEM vs sunitinib (SUN; a standard therapy for RCC) as first-line treatment for advanced RCC. Methods: Pts aged ≥ 18 years with confirmed advanced RCC diagnosis, ≥ 1 measurable lesion per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1, Karnofsky Performance Status ≥ 70, controlled blood pressure, and adequate blood coagulation, renal, hepatic, and bone marrow function are eligible. Pts will be randomized 1:1:1 to receive LEN 18 mg/day + EVE 5 mg/day, LEN 20 mg/day + PEM 200 mg every 3 weeks, or SUN 50 mg/day (on a schedule of 4 weeks on treatment followed by 2 weeks off) until disease progression, unacceptable toxicity, withdrawal of consent, or study end. The primary endpoint is to show superiority of LEN+EVE or LEN+PEM over single-agent SUN as first-line treatment for advanced RCC in improving progression-free survival (PFS). Secondary endpoints include comparison of objective response rate, overall survival, PFS on next-line therapy, health-related quality of life, and safety and tolerability in pts receiving LEN+EVE or LEN+PEM vs SUN. Exploratory endpoints include PFS in the LEN+PEM arm using immune-related RECIST, comparison of duration of response, disease control rate, and clinical benefit rate in pts treated with LEN+EVE or LEN+PEM vs SUN, and analysis of the relationship between blood biomarkers and outcome. No interim analysis is planned for efficacy or futility. Enrollment of 735 pts is planned to achieve 90% power at 2-sided α = 0.05 to detect a difference in ≥ 1 of the primary comparisons. Clinical trial information: NCT02811861.
Archives of Neurology, Chicago
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue Access Provided by Korea University Medical Library JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account
Portable ECG recorder catches syncope in the act
Authors: B. Merz
Journal: JAMA (1983)

There are few things more troublesome to a physician than a patient who reports frequent episodes of syncope. Often such patients are elderly, live alone, and thus have no one who can describe their symptoms or signs leading to unconsciousness. And the possible causes can be numerous—cardiac arrhythmia, epileptic seizure, response to temperature change, or gastric dumping, to name a few. Differential diagnosis often includes equipping the patient with a Holter ECG monitor to record cardiac rhythms during a 24-hour period. Of course, this procedure may be wasted unless the patient experiences syncope on the day he is wearing the monitor. However, the recent introduction of a small cardiac recorder-transmitter has allowed physicians to follow the syncope-prone patient for an extended period. The unit, which weighs approximately 4 ounces (112 g), is designed to be carried in the pocket or purse. At the onset of symptoms, the patient places the
The carrying angle in sex chromosome anomalies
Authors: F. A. Baughman
Journal: JAMA (1974)

The carrying angle is said to be greater in the XO phenotype than in XX and greater in XX than in XY. To determine the effects of the sex chromosomes on the carrying angle, the angles of chromosomally normal and abnormal patients were compared. Among women, only XO phenotypes did not differ substantially from XX. Among men, all comparisons showed a considerable difference, with the difference between XY and XYY phenotypes being highly significant. In sex chromosome aneuploidy, there appears to be a spectrum of elbow abnormalities with maximal cubitus valgus in XO phenotypes at one extreme, decreasing degrees of valgus in XX and XY, and approaching cubitus rectus in cases with one supernumerary X or Y, with cubitus varus and radioulnar synostosis and radial head dislocation where there are multiple supernumerary sex chromosomes. (<i>JAMA</i>230:718-720, 1974)
Public Perceptions of a Radioactively Contaminated Site: Concerns, Remediation Preferences, and Desired Involvement
Authors: David L. Feldman, Ruth A. Hanahan
Journal: Environmental Health Perspectives (1996)

A public attitudes survey was conducted in neighborhoods adjacent to a radioactively contaminated site whose remediation is now under the auspices of the U.S. Department of Energy's Formerly Utilized Sites Remedial Action Program (FUSRAP). The survey's purpose was to ascertain levels of actual and desired public involvement in the remediation process; to identify health, environmental, economic, and future land-use concerns associated with the site; and to solicit remediation strategy preferences. Surface water and groundwater contamination, desire for public involvement, and potential health risks were found to be the most highly ranked site concerns. Preferred remediation strategies included treatment of contaminated soil and excavation with off-site disposal. Among on-site remediation strategies, only institutional controls that leave the site undisturbed and do not require additional excavation of materials were viewed favorably. Cost of remediation appeared to influence remediation strategy preference; however, no strategy was viewed as a panacea. Respondents were also concerned with protecting future generations, better assessment of risks to health and the environment, and avoiding generation of additional contaminated materials.
Particulate allergens potentiate allergic asthma in mice through sustained IgE-mediated mast cell activation
Authors: Cong Jin, Christopher P. Shelburne, Guojie Li, Erin N. Potts, Kristina J. Riebe, Gregory D. Sempowski, W. Michael Foster, Soman N. Abraham
Journal: Journal of Clinical Investigation (2017)

The Editors recently became aware that some of the flow cytometry plots in this article were duplicated and used to represent different samples.Specifically, in Figure 5C, the flow cytometry plots of IFN-γ-and IL-17-stained cells from IgG1-and CXCL10-Ig-treated animals are from the same sample.In addition, in Figure 7A, the spinal cord samples from the PBS-and IgG1-treated animals are the same; the spleen samples from the CXCL11-Ig-and IgG1-treated animals are the same; and the lymph node samples for the PBS-and IgG1-treated animals are the same.The authors were unable to provide the original data for these figures.
Therapeutic attitudes. Cooperators and competitors
Authors: E. J. Beattie
Journal: JAMA (1971)

The first attempts at cures of head and neck cancer by surgical excision began as surgery developed during the 19th century with the discovery of anesthesia and asepsis. These early attempts were mostly unsuccessful. At the beginning of the 20th century, with the discovery of radium and roentgen rays, radiation therapy was added to the treatment of head and neck cancer, but here, too, the results left much to be desired. It was not until the 1940s that surgical excision began to be successful as a competitior or cooperator with radiotherapy. Cancers in the head and neck area are especially significant to the patient because many of these tumors and their subsequent treatment are readily visible to the outside world. In contradistinction, a carcinoma of the abdominal cavity may be fatal without changing the appearance of the patient and his relationship to society. Therapy of patients with head and neck
Hold the sushi
Authors: D. R. Goldmann
Journal: JAMA (1985)

<h3>To the Editor.—</h3> The following case of<i>Diphyllobothrium</i>infestation is presented for its epidemiologic interest. <h3>Report of a Case.—</h3> A 37-year-old woman, previously healthy, complained of three weeks of mild diarrhea, mucus in the stool without blood, and weight loss of 5 lb (2.3 kg). She reported occasionally passing long, flat, segmented structures, which she thought might be worms. The patient worked as a tapestry designer, and her work often took her to New York City, where she frequented Japanese restaurants and sushi bars. The physical examination findings were entirely normal, with no evidence of pallor, glossitis, or neurologic dysfunction. A complete blood cell count and findings from a battery of chemistry studies were normal. A sample of stool showed typical operculated eggs and proglottids of the fish tapeworm<i>Diphyllobothrium</i>. The patient's symptoms resolved with a single dose of niclosamide, and follow-up stool analysis three months later revealed no ova
The Normal distribution
Authors: P. Sedgwick
Journal: BMJ (2010)

Researchers used a cohort study to investigate whether twins and singletons differed in academic performance during adolescence.1 A total of 7796 singletons (a 5% random sample) and 3411 twin individuals born in Denmark from 1986 to 1988 were followed from birth. Cohort members completed a general academic test in the ninth grade of school at the age of 15 or 16. The test covered major domains of academic achievement and was scored between zero and 13. The test scores were normally distributed, with almost identical means and standard deviations (SD) for singletons (n=6575) and twins (n=2866) (mean 8.02 (SD 1.06) v mean 8.02 (SD 1.05); fig 1⇓). Which of the following statements, if any, are true?
Contents
Authors: Adam Muzychuk, Marie-Claude Robert, Stanley Dao, Mona Harissi-Dagher, Ramon Lee, Ziad Khoueir, Edem Tsikata, James Chodosh, Claes Dohlman, Teresa Chen, Jesse Vislisel, Kenneth Goins, Michael Wagoner, Gregory Schmidt, Benjamin Aldrich, Jessica Skeie, Cynthia Reed, M Zimmerman, Mark Greiner, Laura Deinema, Algis Boptom, Yi Vingrys, David Jackson, Holly Chinnery, Laura Downie, Edward Holland, Jodi Luchs, Paul Karpecki, Kelly Nichols, Mitchell Jackson, Kenneth Sall, Joseph Tauber, Monica Roy, Aparna Raychaudhuri, Amir Shojaei, Jack Holladay, Don Calogero, Gene Hilmantel, Adrian Glasser, Scott Macrae, Samuel Masket, Walter Stark, Michelle Tarver, Tieuvi Nguyen, Malvina Eydelman, Parul Chawla Gupta, Jagat Ram, Hesam Hashemian, Mahmoud Jabbarvand, Mehdi Khodaparast, Ali Tabatabaei, Mahesh Shanmugam, Kaustubh Harshey, Rajesh Ramanjulu, Divyansh Mishra, Dnb Reply, John Wells, Adam Glassman, Allison Ayala, Lee Jampol
Journal: Ophthalmology (2016)
Radial neck fracture in a child
Authors: O. E. Aufranc
Journal: JAMA (1967)

Dr. Richard McCollum: The patient is an 8-year-8-month-old girl who fell off of her bed injuring her left arm. She was able to sleep through the night, but by morning considerable pain and swelling was noted and a physician was consulted. Roentgenological studies made at the local hospital revealed a fracture of the neck of the radius with marked displacement of the proximal radial epiphysis (Fig 1). Due to difficulties of transportation from her island community, the patient remained overnight in the local hospital and arrived at the Massachusetts General Hospital 36 hours following her injury. The admission physical examination was entirely normal except for the left elbow which was markedly swollen and tender. The arm was held in 45° of flexion at the elbow and 10° of pronation of the forearm. The patient resisted any attempt to move from this position either actively or passively. The patient also refused
Neonatal drug withdrawal from propoxyphene
Authors: 2N. Quillian
Journal: JAMA (1976)

PROPOXYPHENE hydrochloride (Darvon) is a commonly prescribed drug and is closely related to methadone chemically.<sup>1</sup>According to the manufacturer's literature, tolerance and psychological and physical dependence may occur in adults. To our knowledge, there has been one reported case of neonatal withdrawal symptoms associated with the maternal use of propoxyphene hydrochloride.<sup>2</sup>Our case describes an infant in whom withdrawal symptoms developed and propoxyphene hydrochloride was present in her blood and urine but subsequently cleared. Family physicians, obstetricians, and pediatricians should be alert to the potential danger of this drug to the neonate when it is used regularly during pregnancy. <h3>Report of a Case</h3> A 2,050-gm girl was born to a 29-year-old Rh-negative mother after 34 weeks of gestation. In the fourth month of pregnancy, the mother took 65 mg of propoxyphene hydrochloride four to six times daily because of intermittent right-sided abdominal pain. The dosage was reduced to
Dietary carbohydrates and their glycemic responses
Authors: D. J. Jenkins
Journal: JAMA (1984)

Different carbohydrate foods produce different glycemic responses, as has been recognized for many years.<sup>1-5</sup>However, in terms of dietary advice to diabetics, emphasis has remained on the relative virtue of "complex" carbohydrates (starch) over "simple sugars." The evidence has never been this clear-cut, as indicated by a report in the current issue ofThe Journal<sup>6</sup>on the modest postprandial blood glucose response to ice cream. <h3>Different Glycemic Responses to Different Foods</h3> Studies by Crapo and colleagues<sup>2,5</sup>demonstrated that the glycemic response to glucose was similar to certain starchy foods. Sucrose, with a lower blood glucose response than glucose,<sup>1,3,7-10</sup>produced a rise in blood glucose levels similar to those produced by many commonly eaten starchy foods.<sup>1,3,7-9,11,12</sup>In addition, the blood glucose and insulin responses seen in healthy volunteers were similar when a range of carbohydrates of differing complexity were compared; these included liquid starch, caloreen (a
Affective illness and compusive water drinking
Authors: I. C. Bernstein
Journal: JAMA (1979)

<h3>To the Editor.—</h3> I am concerned that the case of bronchogenic carcinoma described by Gerald J. Vosika, MD (241:594, 1979), may have been a malignant lymphoma—probably a diffuse histiocytic lymphoma in view of the potential confusion with a large cell bronchogenic carcinoma. In my opinion, it is bizarre for a metastatic primary lung carcinoma to have three anatomically unrelated areas of adenopathy and no demonstrable bone or liver involvement. An endobronchial lesion with diffuse histiocytic lymphoma, on the other hand, would not be particularly surprising; certainly, a chemotherapeutic cure would be substantially more likely.
Du Strabisme.
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Health USA
Authors: M. J. Jacobs
Journal: JAMA (1992)

<h3>To the Editor.</h3> —Dr Brown and colleagues<sup>1</sup>are to be commended for the comprehensive national health program developed for Sen Bob Kerrey (D, Neb). Its special value in moving forward the discussion of health care reform is its attention to the provision of how to finance such a change, which is sadly lacking in many previous proposals, including the Pepper Commission report. Not clear, however, in Brown's description, and leaving the reader wondering, is attention to the role of the National Health Care Commission. Our nation's previous experience with health delivery, "administered by the states under federal guidelines and with strong federal financial support" (Medicaid), has been a disaster to state budgets, resulted in drastic underpayment to all providers, and has been drastically unequal in benefits to recipients, depending on their state residency. The recent battle between the Health Care Financing Administration and the unusual coalition of Congress and