tbuckley/cabot-search huggingface dataset:
New Names
Journal: JAMA (1976)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THIAMINE OVERDOSAGE
Authors: Charles LeRoy Steinberg
Journal: JAMA (1941)

<h3>To the Editor:—</h3> In a communication on thiamine overdosage and toxicity inThe Journal, May 3, Dr. Clarence A. Mills, professor of experimental medicine of the University of Cincinnati College of Medicine, stressed the importance of the recognition of symptoms of overdosage of thiamine and the possible danger of the addition of thiamine hydrochloride to bread and other commonly used foods without control over the intake level. He wrote: "Just why no reports of thiamine toxicity have appeared in medical literature is difficult to understand, for the vitamin has been widely used at daily intake levels of 10 to 50 mg. in treatment of deficiency states." I called attention to the untoward effects resulting from the use of continuous and large doses of thiamine as early as December 1938 in the<i>American Journal of Digestive Diseases</i>. The importance of irritation of the peripheral nerves resulting in herpetiform lesions was described.
Fractures
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Errors in Cohort Derivation, Results, Figures, Tables, and Supplement
Authors: Ann O'hare
Journal: JAMA Internal Medicine (2021)

Ann M. O’Hare, MD; Manjula Kurella Tamura, MD; Danielle C. Lavallee, PhD; Elizabeth K. Vig, MD; Janelle S. Taylor, PhD; Yoshio N. Hall, MD; Ronit Katz, DPhil; J. Randall Curtis, MD; Ruth A. Engelberg, PhD
Gastrointestinal Emergencies
Authors: Eddy D. Palmer
Journal: JAMA (1976)

By their natures, medical emergencies must be managed where they occur, and often the advices originating from large medical centers offer a problem, namely, recommendations for techniques and equipment unavailable where 95% of the medicine in the United States is practiced. No such problem is found in this volume. This series of papers, presented at the 34th Hahnemann Symposium, offers a gratifying amount of good bedside and community hospital advice. Particularly useful are the following articles: Samitz's "Skin Clues to Diagnosis of Gastrointestinal Bleeding" (although the illustrations are terrible); a brief down-to-earth "Care of the Child With Gastrointestinal Bleeding" by Gibbons; "Plain Films and Barium Studies in Ischemic Bowel Disease" by Schwartz and Burrell (with excellent illustrations); Tumen's, "Clinical Aspects and Medical Treatment of Toxic Megacolon in Ulcerative Colitis" (he has a way of writing classics); and one of the best clinical discussions of acute pancreatitis of recent times by
Effect of Urogastrone from Adrenalectomized Dogs on Gastric Secretion
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE LATEST ALTITUDE RECORD
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Aerosolized surfactant in sepsis-induced adult respiratory distress syndrome
Authors: C. Doig
Journal: JAMA (1995)

<h3>To the Editor.</h3> —The article by Dr Weg and colleagues<sup>1</sup>is important to all physicians treating patients with adult respiratory distress syndrome (ARDS). Though their article is listed under the heading Preliminary Communication and the primary objective is to assess drug safety, the authors have also assessed potential drug efficacy. It would be useful for readers to have further information before reaching any conclusion about this article. The authors comment that 51 patients were admitted from 20 tertiary care medical centers throughout the United States. Sepsis-induced ARDS is a common condition in most tertiary care intensive care units (ICUs). The authors do not comment on the study interval for patient enrollment, the number of patients screened for entry into the study, the number eligible for enrollment, and the reason for exclusion or refusal of subjects. These data are important if we are to be sure that the study sample
Tick-Borne Tularemia
Authors: Lauri E. Markowitz
Journal: JAMA (1985)

Between June 1 and July 15, 1984, twenty persons with glandular tularemia were identified on the Lower Brule and Crow Creek Indian reservations in South Dakota. The median age of the patients was 6 years (range, 2 to 20 years). The clinical illness was mild, consisting of fever, headache, and lymphadenopathy. All lymphadenopathy was in the head and neck area.<i>Dermacentor variabilis</i>ticks were identified as the vector. Although the mild clinical illness suggested<i>Francisella tularensis</i>, type B, was the agent, both type A and type B strains of<i>F tularensis</i>were isolated from ticks collected from dogs in the area. Tularemia is generally thought to be a severe systemic illness in North America. This outbreak illustrates that it can be a mild disease and that both type A and type B strains can be tick-borne and coexist in the same ecosystem. (<i>JAMA</i>1985;254:2922-2925)
Retinal Detachment
Authors: Daniel F. Marcus
Journal: JAMA (1982)

RETINAL detachment occurs when fluid accumulates between the retina and the pigment epithelium (Fig 1). In primary retinal detachment, fluid passes through a tear or break in the retina, elevating the sensory retina away from the pigment epithelium. In secondary detachment, no break is present and the sensory retina separates from the pigment epithelium by traction (such as in diabetes) or by exudation of fluid into the subretinal space. Secondary retinal detachment may be associated with choroidal tumors, Harada's disease, and a variety of other systemic disorders. Since the retinal detachment has developed as a result of a systemic disease, treatment of the underlying systemic process may result in improvement in the detachment and retinal surgery is not indicated. Historically, retinal detachment has been recognized for several centuries, but it was not until this century that surgical advances improved the prognosis from an incurable condition to one with highly successful
Atlas of Clinical Medicine, by Byrom Bramwell, M.D., etc. Assistant Physician to the Edinburgh Royal Infirmary, etc.
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Systeme international units and familiar formulas: the case of lipids
Authors: P. Giral
Journal: JAMA (1990)

<h3>To the Editor.—</h3> In the Questions and Answers section of the November 24 issue, the respondent asks if physicians practicing at high altitude have seen cases of "return to low-altitude sickness."<sup>1</sup>After 13 years of practice in Los Alamos (altitude, 2230 m [7300 ft]), I have not cared for any patients who complained of this illness. Because of the nature of the employment in Los Alamos, individuals here travel to low-altitude areas frequently. I wonder whether the patient described develops headaches and nausea when she travels to other low-altitude areas and particularly if it develops when she is not visiting her family in New Jersey.
Multifactorial Brugada Phenocopy
Authors: Shiva Sreenivasan, Monica Monaghan, Adrian Baranchuk
Journal: JAMA Internal Medicine (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Stress' route through brain to heart
Authors: W. Check
Journal: JAMA (1978)

Neuroanatomic pathways that may mediate the effects of stress on the cardiovascular system are finally beginning to be defined. "People have talked about the contribution of stress to heart attacks for a long time," says David Cohen, PhD, professor of physiology and director of neuroscience at the University of Virginia School of Medicine. "The mapping of these pathways gives greater credibility to claims that stress is associated with cardiovascular dynamics." Mapping also provides a target for experiments into the mechanism of stress-related heart attacks and ventricular fibrillation (VF) and offers the potential of therapeutic intervention. One important future application of such studies: the problem of sudden death. Separate but related investigations were reported at the recent meeting of the Society for Neuroscience by Cohen and colleagues and by James Skinner, PhD, associate professor in the Department of Neurology and the Neuroscience Program at Baylor College of Medicine, and co-workers. The
Estrogen Receptor-β Prevents Cardiac Fibrosis
Authors: Ali Pedram, Mahnaz Razandi, Fiona O'Mahony, Dennis Lubahn, Ellis R. Levin
Journal: Endocrine Reviews (2010)

Development of cardiac fibrosis portends the transition and deterioration from hypertrophy to dilation and heart failure. Here we examined how estrogen blocks this important development. Angiotensin II (AngII) and endothelin-1 induce cardiac hypertrophy and fibrosis in humans. and we find that these agents directly stimulate the transition of the cardiac fibroblast to a myofibroblast. AngII and endothelin-1 stimulated TGFβ1 synthesis in the fibroblast, an inducer of fibrosis that signaled via c-jun kinase to Sma- and Mad-related protein 3 phosphorylation and nuclear translocation in myofibroblasts. As a result, mesenchymal proteins fibronectin and vimentin were produced, as were collagens I and III, the major forms found in fibrotic hearts. 17β-Estradiol (E2) or dipropylnitrile, an estrogen receptor (ER)β agonist, comparably blocked all these events, reversed by estrogen receptor (ER)β small interfering RNA. E2 and dipropylnitrile signaling through cAMP and protein kinase A prevented myofibroblast formation and blocked activation of c-jun kinase and important events of fibrosis. In the hearts of ovariectomized female mice, cardiac hypertrophy and fibrosis were induced by AngII infusion and prevented by E2 administration to wild type but not ERβ knockout rodents. Our results establish the cardiac fibroblast as an important target for hypertrophic/fibrosis-inducing peptides the actions of which were mitigated by E2/ERβ acting in these stromal cells.
Skills Transfer Program
Authors: Samuel Masket, Alan Crandall, M-3 North, Howard Fine, Stephen Brint, New Mo, L Orleans, A Singer, David Dillman, Robert Cionni, Thomas Neuhann, Marc Michelson, William Fishkind, A Tucson, Steven Shearing, Las Mo, Nv Vegas, E Donald, Santa Dickerson, A Monica, Robert Davison, West Mo, Syd Chester, San Williams, Richard Mateo, ; Lewis, H Reay, Atlanta Brown, Richard Wilson, Samuel Salamon, Peter Rapoza, M-L B North, Anthony Adamis, Kerry Assil, St Louis, Frederick Brightbill, Daniel Goodman, San Francisco, Erich Groos, Marshall Bowes Hamill, Peter Hersh, New York, Kenneth Kenyon, William Mathers, Iowa City, Peter Mcdonnell, Los Angeles, Carrie Parrish, David Schanzlin, Michael Vrabec, R Wittpenn, Frank Polack, M-L B North, Donald Willard, Ned Reinstein, Ok Emily, New Karp, Miguel York, Altamonte Lugo, Rodney Springs, Randy Eve, L Epstein, Kansas Hyde, Peter City, Robert Hartford, Robert Mo, Enrique Notz, W Graue, Edward Holland, ; Thomas, Stephen Slane, Woodford Van Meter, Gregory Smith, Marian Macsai, Richard Mills, Frederick Kapetansky, Donald Minckler, Theodore Krupin, George Baeneldt, Ronald Fellman, Marianne Feitl, G Ferguson, Marc Lieberman, Robert Ewing, Redwood City, Alfred Solish, Beverly Hills, Jeffrey Freedman, Dong Shin, M Ho-, M-4 North, Gordon Douglas, Dale Heuer, Robert Allen, Howard Barnebey, Carl Camras, Mary Mo, E Ann, Palo Lloyd, Mark Alto, Fl Sherwood
Journal: Ophthalmology (1993)
Spontaneous Lobectomy
Authors: D. R. Humphreys
Journal: BMJ (1945)

MEDICAL URNAL185attacks of diarrhoea for some weeks, and three reported alter- nating constipation and diarrhoea.In only one case was there a history of bacillary dysentery.Treatment All cases were given a five-day course of mepacrine 0.1 g. t.d.s.The stools were examined on three successive days after completion of treatment, and on all but two G. lambfla had disappeared.After a second course both were found to be clear.All cases were given a generous diet as soon as the diagnosis was established, and symptoms disappeared by the third day of treatment.The duration of stay in hospital was 14 days; limits, 9 to 41.The 41-day case was that of the officer mentioned previously.He had lost a great deal of weight and required building up.One other case, which had furunculosis as well as giardiasis, was in hospital for 31 days.Owing to the rapidly changing personnel of the station it was possible to follow up only two cases.One had recurrence of diarrhoea after nine months, but on this occasion the cause was bacillary dysentery, and no G. lamblia was found.The second had had recurrent diarrhoea for some months, but' has been free for three months since his treatment.Comment With the exception of two cases all were admitted to hospital when the fly season was at its height.In 1944 seven cases came from one camp and seven from another.A large number of flies from the traps were examined, but no G. lamblia cysts or flagellate forms were detected.It will also be noted that the description of the stools differs somewhat from that of Manson-Bahr (1943), except in two cases with long histories.It is possible that in the Army one gets the cases into hospital at an earlier stage than in civil practice, and this may explain the difference. SummaryTwenty-one cases of diarrhoea believed to be due to infestation with G. lamblia are described.The percentage in relation to other diarrhoeal diseases is stated.Symptoms, physical signs, and treat- ment are discussed.Two cases have been followed up for a short period.We wish to thank
Identification of driver mutations in tumor specimens from 1,000 patients with lung adenocarcinoma: The NCI’s Lung Cancer Mutation Consortium (LCMC).
Authors: M. G. Kris, B. E. Johnson, D. J. Kwiatkowski, A. J. Iafrate, I. I. Wistuba, S. L. Aronson, J. A. Engelman, Y. Shyr, F. R. Khuri, C. M. Rudin, E. B. Garon, W. Pao, J. H. Schiller, E. B. Haura, K. Shirai, G. Giaccone, L. D. Berry, K. Kugler, J. D. Minna, P. A. Bunn
Journal: Journal of Clinical Oncology (2011)

CRA7506 Background: The ability to detect driver mutations like EGFR and EML4-ALK in tumor specimens from patients with lung cancer and administer agents targeting those molecular lesions has revolutionized the management of adenocarcinoma of the lung. The availability of multiplexed assays to detect mutations permits the identification of multiple driver mutations from tumors at diagnosis. The number of molecular lesions and new agents to target them continues to grow. To exploit this, we created the LCMC to determine 10 driver mutations in tumors from 1,000 patients and to give the results to clinicians for care and entry onto targeted therapeutic trials based on these findings. Methods: The 14 member LCMC is prospectively enrolling patients to test tumors from patients with lung adenocarcinoma in CLIA laboratories for KRAS, EGFR, HER2, BRAF, PIK3CA, AKT1, MEK1, and NRAS using standard multiplexed assays and fluorescence in situ hybridization (FISH) for ALK rearrangements and MET amplifications. All are stage IIIB/IV, PS 0-2, have available tissue, and signed consent. Results: 830 patients have been registered with 50 enrolling monthly. We detected a driver mutation in 60% (252/422, 95% CI 55 to 65%) of tumors thus far. Mutations found: KRAS 107 (25%, 95% CI 21 to 30%), EGFR 98 (23%, 95% CI 19 to 27%), ALK rearrangements 14 (6%, 95% CI 4 to11%), BRAF 12 (3%, 95% CI 1 to 5%), PIK3CA 11 (3%, 95% CI 1 to 5%), MET amplifications 4 (2%, 95% CI 0.5 to 5%), HER2 3, (1%, 95% CI 0.1 to 2%), MEK1 2 (0.4%, 95% CI 0.1 to 2%), NRAS 1 (0.2%, 95% CI 0.01 to 1%), AKT1 0 (0%, 95% CI 0 to 1%). 95% of molecular lesions were mutually exclusive. Conclusions: We detected an actionable driver mutation in 60% of tumors from prospectively studied patients with lung adenocarcinoma. Results of EGFR mutation testing are given to treating physicians to select erlotinib as initial treatment per NCCN and ASCO guidelines. Patients with other driver mutations are offered participation in LCMC-linked trials of agents targeting the mutation identified, e.g. crizotinib with EML4-ALK. At half of LCMC sites, multiplexed testing for all mutations is now routine practice in their pathology departments. Supported by 1RC2CA148394-01.
Comparison of Cortical 5-HT2A Receptor Binding in Bulimia Nervosa Patients and Healthy Volunteers
Authors: I. Goethals
Journal: American Journal of Psychiatry (2004)

OBJECTIVE: Bulimia nervosa has been associated with alterations in central serotonergic (5-HT) function. This study investigated iodine-labeled 4-amino-N-[1-[3-(4-fluorophenoxy) propyl]-4-methyl-4-piperidinyl]-5-iodo-2-methoxybenzamide (123I-5-I-R91150) binding to the 5-HT2A receptor in the brain by using single photon emission computed tomography in acutely ill bulimia nervosa patients. METHOD: Cortical 123I-5-I-R91150 binding in 10 normal-weight patients with bulimia nervosa, purging type, was compared with that of 11 healthy volunteers. RESULTS: The 5-HT2A binding index of the bulimia nervosa patients, with and without correction for age, was not significantly different from that of the comparison group. CONCLUSIONS: As a group, acutely ill bulimia nervosa patients cannot be discriminated from healthy subjects on the basis of cortical 123I-5-I-R91150 binding to the 5-HT2A receptor.