tbuckley/cabot-search huggingface dataset:
Intrapleural tetracycline for the prevention of recurrent spontaneous pneumothorax. Results of a Department of Veterans Affairs cooperative study
Authors: R. W. Light
Journal: JAMA (1990)

This prospective, multicenter, randomized, "unblinded," controlled clinical trial was designed to determine if the intrapleural instillation of 1500 mg of tetracycline hydrochloride would be effective in diminishing the ipsilateral rate of recurrence for spontaneous pneumothorax. During the 4-year enrollment period, 113 patients were assigned to the tetracycline group; 116 patients were assigned to the control group. During the 5-year study period, the recurrence rate in the tetracycline group (25%) was significantly less than that in the control group (41%). Use of tetracycline seemed to reduce the recurrence rates for patients with either primary or secondary spontaneous pneumothorax and for patients with either an initial or a recurrent pneumothorax. We conclude that the intrapleural administration of tetracycline in patients with spontaneous pneumothorax significantly reduces the rate of ipsilateral recurrence but is associated with intense chest pain. Intrapleural tetracycline therapy is indicated for patients with a spontaneous pneumothorax who are hospitalized and are treated with tube thoracostomy. (<i>JAMA</i>. 1990;264:2224-2230)
QUALITY AND CONTROLS IN THE BACTERIOPHAGE TYPING OF STAPHYLOCOCCI
Journal: JAMA (1961)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 1559: Increased Length Of Hospitalization And Weight Gain In Diabetic Patients Are Associated With induction of HIF1α expression and Higher serum Levels Of Permeability-inducing Growth Factors: Vegf, And Hgf
Authors: Sirisha Emani, Basel Ramlawi, Neel Sodha, Cesario Bianchi, Frank Sellke
Journal: Circulation (2007)

Background- Inflammatory mediators such as vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) play a critical role in the regulation of vascular permeability, and angiogenesis. We studied the serum levels of several growth factors including VEGF, FGF, and HGF as well as gene expression profiles of genes involved in growth factor signaling in the peripheral blood of patients with diabetes mellitus (DM) and without diabetes mellitus (ND) following cardiopulmonary bypass (CPB) and cardioplegic arrest (C). Methods- Serum for evaluation of growth factors and total RNA for microarray analysis were obtained from the blood samples collected from DM patients (n=8) and matched ND patients (n=8) who underwent coronary artery bypass graft (CABG) or valve procedures; before (pre), 6 hours (6h), and 4 days (4d) after CPB/C. The cytokine panel consisting of growth factors such as VEGF, HGF, FGF, and EGF were quantified in DM and ND patients; pre, 6h, and 4d post-CPB/C using a multiplex cytokine quantification system. cDNA microarray analysis was performed using Affymetrix Genechip U133 plus 2.0 software to assess gene expression of 47,000 genes. Further validation of gene expression was performed by quantitative real-time PCR. Results- Length of hospitalization (9 vs. 6 days post-surgery; p=0.04) and weight gain (6 lbs vs. 2.4 lbs 4d post-surgery; p&lt;0.01) were significantly greater for DM patients when compared to ND patients. VEGF, and HGF were elevated in DM and ND patients; 6h post-CBP/C. The serum levels of these cytokines were elevated significantly in DM patients when compared to ND patients; pre vs. 6h post-CPB/C. In correlation with VEGF protein expression, microarray analysis showed significantly elevated levels of HIF1α mRNA expression (&gt; 4 fold), a critical regulator of hypoxia signaling, 4d after CPB/C exclusively in DM patients. Other transcription factors such as CREB and P300 that directly affect HIF1α expression were also significantly elevated only in DM patients (p&lt;0.01). Conclusion- The unique pattern of gene and protein expression profile of growth factors and their related genes in DM vs. ND patients could be associated with increased edema and weight gain in DM patients after CPB/C.
CIRRHOSIS OF THE LIVER IN EARLY LIFE.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Presentation of Dr. George Herbert Hitchings for the Passano Award
Authors: P. Talalay
Journal: JAMA (1969)

The contributions of George Herbert Hitchings, PhD, to the welfare of mankind during the last quarter of a century have encompassed not only the development of a series of unique and most valuable therapeutic agents, but also the formulation of a set of important strategic guidelines for their rational design. Of this work it may truly be said that the process by which these discoveries were made is equal in interest and importance to the discoveries themselves. Because of the imaginative and unusual nature of these concepts, I wish to give you some measure of the man himself, and the manner in which he set about his life's work. George Hitchings was born in the town of Hoquiam, Wash. Situated in Gray's Bay at the confluence of two rivers, some 12 miles from the Pacific Ocean and in the foothills of the Olympic Mountains, the community concerned itself with lumber,
BELGIUM
Journal: JAMA (1925)

<h3>The Sanitary Situation in the Belgian Congo</h3> In the Presse médicale Daniel and Martin have recently published a study on the ethnologic and sanitary situation in the Belgian colony on the Congo. <h3>MEDICAL ORGANIZATION</h3> The physicians in the service of the state are divided into two classes. In addition to the state medical officials, the large societies have likewise organized a public health service, administered by medical hygienists and resident or traveling physicians. The medical hygienists do not treat patients. The physicians termed "resident or traveling" are distributed throughout the country—supposedly one for each district—and they are entitled to develop a private patronage. The Union minière of Haut-Katanga, which employs from 700 to 800 white and from 10,000 to 12,000 black persons, has twelve physicians. This society has organized its medical service at great expense, and has established two hospitals for Europeans, one at Elizabethville, which is a modern institution
Nachman Ambache
Journal: BMJ (2004)

Epidemiologist who discovered the Lassa fever virus-and nearly died from it Jordi Casals-Ariet, an epidemiologist and virologist, was hailed by scientists around the world when he discovered the virus that causes Lassa fever.He was nearly killed by the disease in 1969 while working with the virus in his Yale laboratory.In a high-stakes gamble and with no known treatment, his doctors decided to transfuse him with blood from a nurse who had survived Lassa fever.The blood saved his life.But colleagues say that Dr Casals' contributions are far greater than his discovery of the Lassa fever virus."He did a yeoman's work in establishing useful methods of classifying viruses," said Dr Gregory Tignor, professor emeritus at Yale, who worked with Dr Casals.Little was known about many viruses when Dr Casals started his work at Yale. "Everybody has forgotten how bad it was back then," said Dr Tignor."People didn't know what was causing encephalitis.We had no way of telling the difference between rabies encephalitis, polio encephalitis, or other causes of encephalitis.But Jordi found ways, using antigens and antibodies, to figure it out.His work was so meticulous that to this day nobody has changed his classifications because they have all held up."
HEMODIALYSIS IN THE HOME
Authors: John P. Merrill
Journal: JAMA (1968)

Treatment of the patient with uremia by hemodialysis has evolved from the use of a clumsy, complicated piece of apparatus requiring the constant supervision of a physician to a point where the patient may safely utilize the procedure himself unattended and in his home. Elsewhere in this issue (p 92) Rae and his associates describe their experience with a home-dialysis program based in a community hospital. Their experience is characteristic of the way this procedure can and should be accomplished. The aim of chronic hemodialysis is to rehabilitate the patient. This being so, it follows that the procedure should be done on an ambulatory basis, associated as little as possible with the atmosphere of the acute hospital. This spares the patient the psychologic disadvantage of being treated in an area with severely ill patients, and it allows highly trained medical personnel to concentrate their efforts upon more acute problems. Furthermore,
KOCH'S NEW TYPHOID PROPHYLAXIS.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Atherosclerosis Regression, Plaque Disruption, and Cardiovascular Events: A Rationale for Lipid Lowering in Coronary Artery Disease
Authors: B. Brown
Journal: Annual Review of Medicine (1993)

Postpartum depression (PPD) is common, disabling, and treatable. The strongest risk factor is a history of mood or anxiety disorder, especially having active symptoms during pregnancy. As PPD is one of the most common complications of childbirth, it is ...Read More
A Comparative Trial of Trimeprazine and Amylobarbitone in Pruritus
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Recent Events of Special Interest to Medical Education
Authors: C. H. William Ruhe
Journal: JAMA (1980)

Since 1966, Section I of theEducation Numberhas been devoted to a review of "Recent Events of Special Interest to Medical Education." Information has been included about special studies, reports, legislation, and other events and activities that are related to medical education and may be expected to influence its future course and direction. The trends identified in last year's report continue to be prominent. Cost containment remains a major issue and appears to influence virtually all proposed federal legislation and regulation in the health field. In addition, much proposed state legislation appears to be motivated by the desire to restrain increasing costs in the health field. The combined impact of legislative proposals at the federal and state levels continues to move slowly in the direction of greater and greater restriction of the independence of individual health practitioners and increasing demand for public accountability. A major development was the withdrawal
Book Listings
Journal: Annals of Internal Medicine (2002)

Book Listings4 June 2002Book ListingsSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-136-11-200206040-00024 SectionsAboutFull Text ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail CardiologyAuscultation Skills: Breath and Heart Sounds2nd edition. Springhouse. 268 pages. Springhouse, PA: Springhouse Corporation; 2002. $50.00. ISBN 1582551588. Order phone 800-588-7738.Cardiac Arrhythmias 2001A Raviele, ed. 657 pages. New York: Springer-Verlag; 2002. $109.00. ISBN 8847001609. Order phone 800-777-4643.Cardiology: Current PerspectivesG Jackson, ed. 404 pages. Philadelphia: Taylor & Francis; 2002. $99.00. ISBN 185317629X. Order phone 800-821-8312.Catheter Ablation of Arrhythmias2nd edition. DP Zipes and M Haissaguerre, eds. 432 pages. Armonk, NY: Futura; 2002. $98.00. ISBN 0879934980. Order phone 800-877-8761.Congenital Heart Disease in the AdultWM Gersony and MS Rosenbaum. 304 pages. New York: McGraw-Hill; 2002. $99.00. ISBN 0070329095. Order ... Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 4 June 2002Volume 136, Issue 11Page: B1KeywordsComputed axial tomographyHealth careMilkPrevention, policy, and public healthRacial and ethnic issues ePublished: 4 June 2002 Issue Published: 4 June 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.Loading ...
Thermolabile methylenetetrahydrofolate reductase in coronary artery disease
Authors: F.F. Willems, L.E.J. Kluijtmans, J.P. Kastelein, J. Lindemans, G.H.J. Boers, A.V.G. Bruschke, F.M.F. Trijbels, G.J.M. Boerma, W.W.J. Jukema, F.W.A. Verheugt, H.J. Blom
Journal: Journal of the American College of Cardiology (1998)
Phase I-II trial of a novel mixed haptenized autologous melanoma vaccine
Authors: D. Berd, T. Sato, J. Kuchar, T. Riley, M. J. Mastrangelo
Journal: Journal of Clinical Oncology (2004)

2563 Background: We have reported positive immunological and clinical results in patients treated with an autologous tumor cell vaccine modified with the hapten, dinitrophenyl (DNP). Now we have developed a second generation technology consisting of irradiated, autologous tumor cells, half of which are modified with DNP and half with a second hapten, sulfanilic acid (SA). Methods: Freshly-dissociated, cryopreserved tumor cells (TC) are irradiated (2500 cGy); then half of the cells are modified with DNP and half with SA. After combining them, the “mixed haptenized” cells are fixed in a low concentration of ethanol, aliquotted, and frozen. Each vaccine batch is tested for sterility, endotoxin, and flow cytometric expression of melanoma-associated antigens. In an ongoing phase I–II trial, patients with stage IV melanoma are administered the vaccine at one of three dosage levels (0.05x106, 0.50 x106, or 5.0 x106 cells/dose) using a previously determined optimal schedule of administration. Before and after a 10-week course of vaccine, patients are tested for delayed-type hypersensitivity (DTH) (≥5 mm induration at 48 hours) to autologous melanoma cells, hapten-modified and unmodified, and to control materials. Results: 19 patients have been entered onto the trial. Of the 10 patients who have completed pre- and post-vaccine testing, the DTH results are as follows: Two patients developed inflammatory responses in superficial metastases; biopsy of one of these showed lymphocytic infiltration and necrosis. So far there have been three patients with documented tumor regression, all of whom are classified as mixed responses. One response was in pelvic lymph node and the other two were subcutaneous metastases. Conclusions: This autologous, mixed haptenized melanoma vaccine appears to elicit anti-tumor T cell responses that may be clinically meaningful. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration AVAX Technologies, Inc. AVAX Technologies, Inc. AVAX Technologies, Inc.
BERIBERI TODAY
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Of mugs and marketing
Authors: Michael J. Kelly
Journal: JAMA (1991)

<h3>To the Editor.</h3> —In Dr Rennie's recent response<sup>1</sup>to Dr Goldstein's commentary,<sup>2</sup>it appeared that the excessive cost of an association-sponsored journal over one with drug company advertising was said to justify the impropriety or the "appearance" of impropriety involved in accepting advertising. It was further suggested that editorial decisions are somehow separated from advertising decisions, making a peer-reviewed journal somehow immune from the undue influence of the pharmaceutical industry. These explanations seem to be ones of convenience, not ethical arguments. Although I pay dues to the AMA, as a family physician I cannot receive the<i>Archives of Internal Medicine</i>without paying an extra fee each year. An internist who is not a member of the AMA can receive the<i>Archives of Internal Medicine</i>free each month. The reason this happens relates to the type of circulation the AMA must provide in order to attract and hold certain
Patients' compliance with health regimens
Authors: I. M. Rosenstock
Journal: JAMA (1975)

EVERY practicing physician soon learns that the proper diagnosis and recommended treatment of disease constitutes only half his task. The other half, of equal importance, concerns the extent to which the patient complies with his recommendations. A variety of studies have shown noncompliance rates that vary between 30% and 70% over a wide range of conditions and recommended actions, but apparently average about 50%; ie, 50% of your patients will not follow prescribed regimens precisely as ordered or for the full period of time of the prescription. This may come as no surprise when one considers such areas as obesity, cigarette smoking, and exercise, but it may surprise some physicians that these figures hold even for the taking of relatively simple medications that do not involve marked changes in life-style. <h3>Reasons for Noncompliance</h3> Within the past few years, accumulating evidence has thrown considerable light on the reasons for noncompliance with
National Cancer Institue Monographs Nos. 29, 30, 31, and 32
Journal: JNCI Journal of the National Cancer Institute (1969)

Journal Article National Cancer Institue Monographs Nos. 29, 30, 31, and 32 Get access JNCI: Journal of the National Cancer Institute, Volume 43, Issue 6, December 1969, Pages 1383–1385, https://doi.org/10.1093/jnci/43.6.1383 Published: 01 December 1969
Computerizing the blood smear report
Authors: J. W. Linman
Journal: JAMA (1972)

The first of two studies on the use of computer-based techniques for reporting blood smear interpretations involved nine physicians, each reporting the analyses of 24 blood smears via a light pen-video console. Ten physicians participated in the second study with analyses of 40 blood smears reported via mark-sense cards. In each study, the controls were the same physicians making an equal number of reports via the present pencil and paper method. Objective comparisons and hematologists' subjective evaluations were favorable toward both computerized methods.