tbuckley/cabot-search huggingface dataset:
Workmen's Compensation Acts In the United States. The Medical Aspect.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Trichloroethylene neuropathy.
Authors: E. L. Lloyd
Journal: BMJ (1969)

Utidjian are quite right (8 March, p. 641).Conization (also our routine apart from pregnancy) is a more complete method of investigating a posi- tive smear than our cervical inspection and four-quadrant small biopsies.Over the period from 1958 to 1967 we have asked our patients in the interest of the baby to accept our advice, with the tiny risk that ill fortune had dealt what A. T. Hertig calls the "joker in the pack"-,that is, not only carcinoma-in-situ but 'a tiny area of invasive, perhaps metastatic, carcinoma.Since 1966 we have added to our investigatory team J. A. Jordan, an expert in modern colposcopy, which uses subepithelial vascular patterns to locate abnormal epithelium.24Small biopsies may be taken from target areas, but for the most part the dilatable pregnant cervix reflects the positive smear-namely, carci- noma-in-situ or epithelial dysplasia: these areas 'are now left alone until after delivery and planned conization eight weeks later.May I pose two questions to colleagues who undertake routine conization in preg- nancy ?(1) How often is pregnancy disturbed by this technique ?Manifestly loss of a poten- tial child and at histology the presence of no more than epithelial dysplasia is a poor bargain.(2) How often do you excise the epithelial lesion completely-that is, how often is post- delivery conization again indicated by per- sistently positive smears ?-I am, etc.,
Emotional Hygiene: The Art of Understanding
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Vertex Occipitoposterior Position.
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Biological Effects of Short-Term, High-Concentration Exposure to Methyl Isocyanate. II. Blood Chemistry and Hematologic Evaluations
Authors: Catherine M. Troup, Darol E. Dodd, Edward H. Fowler, Fred R. Frank
Journal: Environmental Health Perspectives (1987)

Human, rat, and guinea pig packed erythrocytes exposed to 100, 500, or 1000 ppm of methyl isocyanate (MIC) vapor in vitro showed a concentration-related inhibition of cholinesterase (ChE) activity. Rat and guinea pig packed erythrocytes showed an almost complete inhibition of ChE activity at 2000 ppm. In vitro exposures of human and guinea pig blood to 1000 or 2000 ppm of MIC vapor resulted in qualitative alterations in the electrophoretic mobility of hemoglobin (Hb) as measured by citrated agar electrophoresis. In rats and guinea pigs, neither IV injection of liquid MIC nor in vivo exposure to 1000 ppm of MIC by inhalation resulted in any inhibition of erythrocyte ChE activity or alteration in Hb electrophoretic mobility. As a result of these observations, it was concluded that neither ChE inhibition nor structural alteration of Hb were major contributing factors to death resulting from MIC exposure. Rats and guinea pigs receiving IV injections of liquid MIC showed an increase in creatine kinase (CK) levels. This increase could not be attributed to a specific isoenzyme of CK by ion exchange chromatography. Rats exposed to 100, 600, or 1000 ppm of MIC and guinea pigs exposed to 25, 125, or 225 ppm of MIC and bled immediately following a 15-min exposure or at 1, 2, 4, or 16 hr postexposure had the following alterations in blood parameters: an increase in CK, increases in hemoglobin concentration and hematocrit, reticulocytosis (rats only), neutrophilia, a decrease in blood pH and PO2, and an increase in blood PCO2.(ABSTRACT TRUNCATED AT 250 WORDS)
A Vulnerable Side to MYC-Driven Cancers
Journal: Cancer Discovery (2015)

Although aberrant MYC activity confers protumorigenic effects on cancer cells, it also adds stress by increasing the amount of pre-mRNA substrates for the spliceosome to process. New research indicates that MYC-driven cancers depend on an intact, functional spliceosome for survival; targeting this multiprotein complex could therefore be an indirect therapeutic strategy against a highly drug-resistant oncogene.
Early evolutionary divergence between papillary and anaplastic thyroid cancers
Authors: J. Capdevila, R. Mayor, F.M. Mancuso, C. Iglesias, G. Caratú, I. Matos, C. Zafón, J. Hernando, A. Petit, P. Nuciforo, J.M. Cameselle-Teijeiro, C.V. Álvarez, J.A. Recio, J. Tabernero, X. Matias-Guiu, A. Vivancos, J. Seoane
Journal: Annals of Oncology (2019)

Ann Oncol 2018; 29(6): 1454–1460 (doi: 10.1093/annonc/mdy123) The author name “C. Álvarez” has been changed to read “C. V. Álvarez”. Early evolutionary divergence between papillary and anaplastic thyroid cancersAnnals of OncologyVol. 29Issue 6PreviewPapillary thyroid cancer (PTC) is the most common thyroid carcinoma and exhibits an almost uniformly good prognosis, while anaplastic thyroid cancer (ATC) is less frequent and is one of the most aggressive cancers usually resistant to conventional treatment. Current hypothesis posits that ATC derives from PTC through the progressive acquisition of a discrete number of genomic alterations and implies that the mutational landscape of ATC resembles that of PTC. However, the clinical behaviour of ATC and PTC is radically different. Full-Text PDF Open Archive
Abstract 532: Effect of 3-hydroxy-3-methylglutaryl-CoA Reductase Inhibitors on Renal Function
Authors: Rishi Sukhija, Zoran Bursac, Rajesh Sachdeva, Jawahar Mehta
Journal: Circulation (2007)

Background : 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors (statins) reduce serum cholesterol, and cardiovascular morbidity and mortality. The role of lipids in the progression of kidney disease and the potential beneficial effects of statins on renal function is unknown. Oxidative stress and inflammation may be the missing link between CAD and chronic kidney disease. Statins may protect the kidney through both lipid lowering properties and pleiotropic effects. Methods : We analyzed data in 197, 551 patients (mean age 64.8 ± 13.6 years, 95% males, 29.5% (58,332) statin users, and 70.5% (139, 219) non-statin users), who had baseline creatinine less than 3.5 mg/dl, from the cross-sectional data mined from the Veterans Affairs VISN 16 database. Deterioration of renal function was defined as doubling of the baseline or increase in creatinine of 0.5 mg/dl over at least 90 days. Results : Based on this definition, 3.4% of patients developed renal deterioration over 5 year of follow-up. After adjustment for demographics, diabetes mellitus, smoking, and other medications (especially use of angiotensin-converting enzyme inhibitors, calcium channel blockers and aspirin, all of which were confounders of the statin-renal deterioration relationship), use of statins reduced the odds of deterioration in renal function by 15% (OR 0.85, 95% CI = 0.80 – 0.89, p &lt; 0.0001). This effect was independent of cholesterol lowering effect of statins. Impact of other variables was as follows: age (OR = 1.04, CI = 1.03–1.04, p &lt; 0.0001), diabetes (OR = 1.76, CI = 1.67–1.85, p &lt; 0.0001), and smoking (OR = 1.76, CI = 1.05–1.23, p = 0.0014). Conclusion : Statin use may retard the progression of renal disease. Although the precise mechanism is not known, lowering of LDL-cholesterol and improvement in endothelial function by statins may relate to reno-protective effect.
Tales of discovery, obfuscation, error, and improvement
Journal: BMJ (2002)

reported in several countries and reports of gonorrhoea have increased in France, the Netherlands, Sweden, Switzerland, and the United Kingdom.These preliminary data, the authors say, imply that people may increasingly take sexual risks and that complacency over HIV transmission may have set in among individuals, populations, and some governments in western Europe.Efforts to prevent the transmission of HIV need to be strengthened, and consistent surveillance needs to be established at a European level.
Program of the Scientific Assembly
Journal: JAMA (1961)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 2234: Self-care And Quality Of Life In Patients With Heart Failure
Authors: Chantira Chiaranai, Jeanne Salyer
Journal: Circulation (2007)

Purpose: Although it is well-known that self-care (SC) reduces the frequency of hospital admissions and exacerbations, and enhances quality of life (QOL) in heart failure patients, little is known about SC in this population. The study purpose was to examine relationships among selected individual characteristics (demographics, severity of illness, co-morbidities, and social support), SC strategies, and QOL using Reigel’s Model of Self Care in Patients with Heart Failure as the guiding framework. Method: 114 subjects were recruited to participate in this descriptive correlational study. SC was measured using the Self-Care of Heart Failure Index , which measures self-care maintenance (SC-Mt), self-care management (SC-Mn), and self-care self-confidence (SC-Sc). QOL was measured using a disease-specific instrument, the Minnesota Living with Heart Failure Questionnaire , and a generic instrument, the Short-Form Health Survey characterizing physical and mental-emotional functioning. Multiple regression analysis was used to identify predictors of QOL. Findings: 98 subjects (age = 56.7 years; 53.8% male; 49.5% Caucasian) completed and returned mailed questionnaires. Multiple regression analyses demonstrated that better disease-specific QOL was predicted by being less likely to try SC-Mn strategies (β = .325; p = 0.003), better SC-Sc (β = −.251; p = 0.012), better NYHA functional class (β = .246; p = 0.008), and less co-morbidity (β = .236; p = 0.014) (R 2 = .334; F = 7.269, p = 0.000). Better generic QOL (physical functioning) was predicted by better NYHA functional class (β = −.309; p = 0.001), better SC-Mt (β = .205; p = 0.037), better SC-Sc (β = .296; p = 0.003), and being less likely to try SC-Mn strategies (β = −.165; p = 0.000) (R 2 = .361; F = 9.602, p = 0.000). Better generic QOL (mental-emotional functioning) was predicted by better NYHA functional class (β = −.229; p = 0.024), and being men (β = −.204; p = .047) (R 2 = .277; F = 4.548, p = 0.000). Discussion: Findings suggest that better QOL is influenced by gender (male), better NYHA functional class, less co-morbidity, and better use of SC strategies. Exploring patient decision-making can assist nurses in identifying how to improve decision-making performance and enhance QOL.
Council on Physical Therapy
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE ULTIMATE RESULTS OF THE BLOODLESS REPLACEMENTS OF CONGENITALLY DISLOCATED HIPS.
Authors: JOHN RIDLON
Journal: JAMA (1904)

In selecting the subject of this paper I have been actuated by divers motives, but chiefly by the hope that a straightforward presentation of the facts, insofar as I have been able to obtain them, may correct certain delusions and false impressions that have crept into the minds of medical men and others, mainly through uninformed writers of sensational newspaper articles. For the past five years no subject in orthopedic surgery has been of greater interest to me than this one—the bloodless replacement of congenitally dislocated hips. For the past three years no operation has been more generally discussed by the profession and the laity. No subject has been more persistently misrepresented by the lay press and, I regret to say, by the editorial writers of the medical press, and more thoroughly misunderstood than the results of this operation. Enough hips have now been operated on and enough time
Exertional Rhabdomyolysis
Authors: James P. Knochel
Journal: New England Journal of Medicine (1972)

Acute disintegration of muscle and myoglobinuria after intense, prolonged or repetitive physical exertion has become a widely recognized clinical entity. It appears that such rhabdomyolysis may occur in normal men provided they are under sufficient physical stress. Indeed, highly specialized laboratory technics suggest that detectable quantities of myoglobin appear consistently in serum and urine after extreme muscular activity or trauma such as that incurred during participation in contact sports.1 Moreover, in untrained but not in trained men, intense exercise is consistently followed by a rise of CPK, SGOT, and LDH activity in serum to abnormally high values, presumably reflecting skeletal . . .
Critique of the Coggeshall report "planning for medical progress through education"
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
DNA vaccination with CD25 protects rats from adjuvant arthritis and induces an antiergotypic response
Authors: Avishai Mimran, Felix Mor, Pnina Carmi, Francisco J. Quintana, Varda Rotter, Irun R. Cohen
Journal: Journal of Clinical Investigation (2004)

Ab's to the α-chain of the IL-2 receptor (anti-CD25) are used clinically to achieve immunosuppression. Here we investigated the effects of DNA vaccination with the whole CD25 gene on the induction of rat adjuvant arthritis. The DNA vaccine protected the rats and led to a shift in the cytokine profile of T cells responding to disease target antigens from Th1 to Th2. The mechanism of protection was found to involve the induction of an antiergotypic response, rather than the induction of anti-CD25 Ab's. Antiergotypic T cells respond to activation molecules, ergotopes, expressed on syngeneic activated, but not resting, T cells. CD25-derived peptides function as ergotopes that can be recognized by the antiergotypic T cells. Antiergotypic T cells taken from control sick rats did not proliferate against activated T cells and secreted mainly IFN-γ. In contrast, antiergotypic cells from CD25-DNA–protected rats proliferated against activated T cells and secreted mainly IL-10. Protective antiergotypic T cells were found in both the CD4+ and CD8+ populations and expressed α/β or γ/δ T cell receptors. Antiergotypic α/β T cells were MHC restricted, while γ/δ T cells were MHC independent. Thus, CD25 DNA vaccination may induce protection from autoimmunity by inducing a cytokine shift in both the antiergotypic response and the response to the antigens targeted in the disease.
GLUE-SNIFFING
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pathology in the Soviet Union
Authors: F. K. Mostofi
Journal: JAMA (1980)

. Five pathologists from the United States visited the Soviet Union for three weeks in April 1978 to learn of the training in and the practice of pathology in that country. The major observations of the Americans were that (1) pathology is a medical specialty in the Soviet Union, with practice limited to anatomic pathology; (2) exfoliative cytology and clinical pathology are not part of pathology; (3) interest, both clinical and experimental, in occupational, environmental, and geographic pathology is conspicuous; (4) an autopsy rate of 90% to 95% is customary; and (5) there is an organized and hierarchical framework for practice, with career patterns established early and change infrequent. (<i>JAMA</i>243:248-251, 1980)
Hepatology Highlights
Authors: Clara Tow, Robert S. Brown, Zaid Husni Tafesh, Robert E. Schwartz, Russell Rosenblatt, Shawn L. Shah, Nicole T. Shen, Aleksey Novikov, Shirley Cohen‐Mekelburg, Nicholas Russo, Vikas Gupta
Journal: Hepatology (2017)

Tow, Clara; Brown, Robert S. Jr.; Tafesh, Zaid Husni; Schwartz, Robert E.; Rosenblatt, Russell; Shah, Shawn L.; Shen, Nicole T.; Novikov, Aleksey; Cohen‐Mekelburg, Shirley; Russo, Nicholas; Gupta, Vikas Author Information
361O Patient-reported outcomes (PROs) in recurrent or metastatic (R/M) squamous cell carcinoma of the head and neck (SCCHN) treated with nivolumab (Nivo) or Investigator's Choice (IC): CheckMate 141
Authors: N. Kiyota, K. Harrington, R.L. Ferris, J.W. Shaw, F. Taylor, M. Derosa, D. Turner-Bowker, L. Morrissey, K. Cocks, M. Gillison, J. Guigay
Journal: Annals of Oncology (2016)