tbuckley/cabot-search huggingface dataset:
MEMBERSHIP OF EDUCATIONAL COMMITTEES (AS OF JULY 1, 1984)
Journal: JAMA (1984)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Germinal Tumors Exhibiting the Endodermal Sinus Pattern of Teilum in Young Children
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
American Journal of Diseases of Children, Chicago
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
NUTRITION IN NATIONAL EMERGENCIES
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Localization of occult testicular tumor with scrotal thermography
Authors: Y. T. Lee
Journal: JAMA (1976)

TESTICULAR tumors commonly appear as a painless enlargement of the testis accompanied by a feeling of scrotal heaviness or pain. However, in 4% to 14% of patients with malignant testicular disease, the first manifestations are those resulting from metastatic deposits.<sup>1</sup>In most of these patients, physical examination of the testicles shows an obvious tumor, but in a small group, no primary tumor can be detected even by repeated examinations. Rudnick and Odell<sup>2</sup>reported the case of a young man with excessive serum gonadotropin levels, but an extensive search, including surgical exploration of both testes, failed to disclose a malignant neoplasm. The patient died one year later, and at autopsy, the primary tumor was found in the left testis. These authors proposed that in the absence of signs or symptoms suggesting a neoplasm elsewhere, the most likely site of a gonadotropin-producing neoplasm in a man is the testes, one
Lessons for Neurotoxicology from Selected Model Compounds: SGOMSEC Joint Report
Authors: Deborah C. Rice, Ana Maria Evangelista de Duffard, Ricardo Duffard, Anders Iregren, Hiroshi Satoh, Chiho Watanabe
Journal: Environmental Health Perspectives (1996)

The ability to identify potential neurotoxicants depends upon the characteristics of our test instruments.The neurotoxic properties of lead, methylmercury, polychlorinated biphenyls, and organic solvents would all have been detected at some dose level by tests in current use, provided that the doses were high enough and administered at an appropriate time such as during gestation.The adequacy of animal studies, particularly rodent studies, to predict intake levels at which human health can be protected is disappointing, however.It is unlikely that the use of advanced behavioral methodology would alleviate the apparent lack of sensitivity of the rodent model for many agents.Environ Health Perspect 1 04(Suppl 2):205-215 (1996) Key words: lead, methylmercury, neurotoxic
CHILE
Journal: JAMA (1953)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Results of a phase I/II study with monoclonal antibody CG250 in combination with IFN α-2A in metastatic renal cell carcinoma patients
Authors: P. Bevan, C. Mala, M. Kindler, M. Siebels, R. Oberneder, H.-J. Beck
Journal: Journal of Clinical Oncology (2004)

4606 Background: cG250 (WX-G250, Renecarex) is a chimeric monoclonal antibody of IgG1 subtype that binds to the cell surface antigen of carboxyanhydrase IX (MN antigen) that is found on 95% of clear cell RCC cells but not on normal kidney tissue. A multi-center, open-label, prospective, single-arm phase I/II trial study has been performed, evaluating the safety and efficacy of repeated doses of WX-G250 in combination with IFN α-2a in a total of 32 patients with metastatic RCC. Methods: Patients with stage IV renal cell carcinoma, nephrectomy for the primary tumor, in progression at study entry and with measurable bidimensionally disease between ≥1 cm and ≤5 cm in diameter were included in the study. WX-G250 was applied once weekly for 3 months at 20 mg by iv infusion (total dose). In addition, patients were treated with IFN α-2a, 3 MIU, 3 times per week subcutaneously. In week 16, in the event of stable disease or tumor response, continuation of treatment with the WX-G250 for 6 more weeks was offered. Results: Of 32 enrolled patients, 31 patients could be analyzed. The safety population patients (n = 31) experienced a total of 183 adverse events (AEs). The AEs which were definitely related to study medication (39/183, 25.8%) were of toxicity grade 1 and 2. They mainly comprised 'constitutional symptoms' (22 AEs, 25.8%) and 'pain' (13 AEs, 12.9 %), described as typical side effects of the treatment with cytokines. No immunological response (HACA) could be detected during the course of WX-G250 treatment. Tumor assessment was performed by the investigators by computertomography (CT)-evaluation. Preliminary primary efficacy results were determined by tumor assessment in week 16 with 83.3% of the patients (N=26). 11.5% (N=3) of these patients showed PR, 46.2% (N=12) SD and 42.3% (N=11) PD. All results are subject to further evaluation by an independent radiologist. Data collection on TTP and OS are still ongoing. Conclusions: Treatment with WX-G250 is generally safe and well tolerated. Objective tumor responses and disease stabilization can be considered as clinically meaningful and are of clinical benefit for this metastatic patient population. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Wilex AG Wilex AG
Role of Cardiovascular Risk Factors in Prevention and Treatment of Macrovascular Disease in Diabetes
Journal: Diabetes Care (1991)

iabetes mellitus is a major risk factor for morbidity and mortality due to coronary heart disease, cerebrovascular disease, and peripheral vascular disease in the United States.The prevalence of these macrovascular complications is increased about two-to fourfold in diabetic populations.In 1987, these macrovascular complications accounted for most of the hospitalizations for diabetes and contributed substantially to the $20.4 billion spent for diabetes care in the United States.Multiple risk factors for macrovascular disease are frequently found in individuals with diabetes.There is an increased prevalence of hypertension and lipid abnormalities in many populations with diabetes.Many individuals with diabetes have not stopped smoking despite evidence that this is a major cardiovascular risk factor.There are other factors that may be associated with macrovascular disease in diabetes, including obesity, impaired glucose tolerance (IGT), hyperglycemia, hyperinsulinemia, microalbuminuria, elevated fibrinogen levels, altered platelet function, and qualitative lipoprotein abnormalities.Primary and secondary intervention trials directed at cardiovascular risk factors in nondiabetic individuals have been performed, and data are now available.Advances have also been made in nutritional management, exercise programs, behavioral approaches, pharmacological therapy for diabetes and its major risk factors, and the understanding of atherogenesis.These developments led the American Diabetes Association (ADA) to convene a consensus development conference, 10-12 May 1989, on the role of cardiovascular risk factors in the prevention and treatment of macrovascular disease in diabetes.
Abstract 992: Comparative analyses of drug-loaded exosomal preparations from different cell types reveal distinctive loading capability, yield, and anti-tumor efficacies
Authors: RAJASHEKHAR KANCHANAPALLY, Sachin Kumar Deshmukh, Suhash Reddy Chavva, Nikhil Tyagi, Sanjeev Kumar Srivastava, Girijesh Kumar Patel, Ajay P. Singh, Seema Singh
Journal: Cancer Research (2019)

Abstract Cancer remains one of the leading causes of death worldwide regardless of technological advancements. Inefficiency of current drug-delivery regimes is one of the important factors that limits the therapeutic efficacy of existing chemotherapeutics thus contributing to cancer mortality. To address this limitation, synthetic nanotechnology-based delivery systems have been developed; however, they raise concern of inducing adverse immunogenic reactions. Exosomes are non-immunogenic nano-sized vesicles that have received significant attention as efficient drug delivery system. Here we evaluated the efficacy of different cell types viz. pancreatic cancer cells (PCCs), pancreatic stellate cells (PSCs) and macrophages (MØs) for drug packaging and release into exosomes. PCCs shed the most exosomes and were the most efficient in drug loading followed by MØs and PSCs as examined by HPLC quantification. However, when compared for anti-tumor efficacy, MØs-derived exosomes-loaded with DOX (MØ-Exo-DOX) showed highest activity followed by PSCs and PCCs in WST-1 and Annexin V staining assays. These varying anti-tumor activities likely resulted from non-drug contents of exosomes since we did not observe any significant differences in their uptake by the cancer cells. Altogether, our data suggest that donor cell-specific differences exist in exosomes, which could influence their utility as drug carrier for therapeutic purposes. Citation Format: RAJASHEKHAR KANCHANAPALLY, Sachin Kumar Deshmukh, Suhash Reddy Chavva, Nikhil Tyagi, Sanjeev Kumar Srivastava, Girijesh Kumar Patel, Ajay P. Singh, Seema Singh. Comparative analyses of drug-loaded exosomal preparations from different cell types reveal distinctive loading capability, yield, and anti-tumor efficacies [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 992.
Annual Report for the Year 1932 of the Egyptian Government, Central Narcotics Intelligence Bureau.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dose-Rate Dependence of Early Radiation Effects in Small Mammals
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Association News.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Genital human papillomavirus infection in female university students as determined by a PCR-based method
Authors: H. M. Bauer
Journal: JAMA (1991)

The presence of genital human papillomavirus (HPV) was determined at cervical and vulvar sites using two methods, the Food and Drug Administration—approved Vira Pap test and polymerase chain reaction (PCR) DNA amplification technology, in 467 women presenting to a university health service for a routine annual gynecologic examination. The PCR system afforded the sensitive detection of a broad spectrum of genital HPV types. Using PCR, we found that 46% of the study population was infected with HPV; the ViraPap test showed a prevalence of 11% infected. PCR analyses demonstrated that 69% of the HPV-positive women were infected at both genital sites. Subsequent HPV-type determination showed that 33% of the study population had HPV types 6, 11, 16, 18,31,33,35,39,45,51,52, or other previously isolated types, and 13% had yet unidentified types. Almost all (92%) of the women diagnosed by Papanicolaou smear with condylomatous atypia or dysplasia (n = 12) were HPV positive. The PCR method proved to be an informative and rapid way to detect HPV in large numbers of clinical samples. Our results demonstrate that genital HPV infection is common among sexually active young women. (<i>JAMA</i>. 1991;265:472-477)
Researcher fined for shredding records
Journal: BMJ (2005)

transformation seems to be higher in cardioembolic stroke.w38 w39 Whether asymptomatic haemorrhagic transformation significantly influences early or long term outcome is debatable.Conversion of asymptomatic haemorrhagic transformation into symptomatic intracerebral haemorrhage with early anticoagulation, however, would be a legitimate concern.Factors leading to haemorrhagic transformation (for example, duration of ischaemia, speed of recanalisation, baseline neurological status, and demographic and imaging characteristics) may help in the timing of anticoagulation in the future.w40 w41 There is some information but no randomised controlled trials about resuming anticoagulation in patients with intracerebral haemorrhage and prosthetic heart valves. 24w42-w44 There is no information on how soon anticoagulation could be started safely, if at all, in patients with atrial fibrillation after intracerebral haemorrhage. OutcomeAfter our patient's intracerebral haemorrhage, we identified control of blood pressure and diabetes as the areas needing most attention.Overall compliance rather than truly "difficult to control" hypertension seemed to be the problem.We started him on warfarin two weeks after the second (ischaemic) stroke while recognising that he was a very high risk both for future thromboembolism and for intracerebral haemorrhage and therefore would need very close monitoring.He did not make any substantial functional recovery and needed care in a nursing home.However, lately he has been showing some signs of improvement.His blood pressure, international normalised ratio, and diabetes are being regularly monitored.Supervision in the care home has improved compliance with medication.We acknowledge the lack of evidence for prescribing dipyridamole in preference to aspirin.We also recognise that the area is full of uncertainties, and owing to lack of clear evidence we have not been able to manage the dilemmas with full confidence.We hope that the debate generated by this case might focus researchers' attention on this very important area.We need large scale, well designed trials to help us advise our patients more appropriately in this particularly complex situation.
Reduced microvascular and myocardial damage in patients with acute myocardial infarction and ischemic preconditioning due to preinfarction angina Paolo Colonna, Christian Cadeddu, Abdel Hakeem Selem, Roberta Montisci, Lijun Chen, Massimo Ruscazio, Enrico Onnis, Luigi Meloni, Sabino Iliceto. Department of Cardiovascular and Neurological Sciences, University of Cagliari, Cagliari, Italy
Journal: Journal of the American College of Cardiology (2001)
Table of Contents
Authors: Jennifer Powers, Catherine Higham, Karen Broussard, Tania Phillips, Afsaneh Alavi, R Sibbald, O Miller, David Margolis, William Marston, Kevin Woo, Marco Romanelli, Robert Kirsner, Lana Kashlan, Alexander Egeberg, Peter Hansen, Hilmar Gislason, Jacob Pontoppidan Thyssen, Gregory Delost, Maria Delost, James Armile, Jenifer Lloyd, Kurt Ashack, Kyle Ba, Teresa Burton, Dustin Currie, R Dawn Comstock, Robert Dellavalle, Alejandra Tellez, Steven Rueda, Ruzica Conic, Kristin Powers, Izabela Galdyn, Natasha Mesinkovska, Brian Gastman, Abram Beshay, Michael Liu, Lindy Fox, Kanade Shinkai
Journal: Journal of the American Academy of Dermatology (2016)