tbuckley/cabot-search huggingface dataset:
CEA for Monitoring Colon Cancer
Authors: Alfred M. Cohen
Journal: JAMA (1994)

<h3>To the Editor.</h3> —Moertel and colleagues<sup>1</sup>are unable to see the trees for the forest. The incremental overall survival benefit in patients with elevated CEA levels in their cohort of patients is slightly less than 1%. However, a larger group of patients actually benefited in that they underwent potentially curative reoperation, particularly hepatic resection. Probable outcomes in the operative treatment of hepatic metastases from colorectal cancer should be related to patient subsets. There are approximately 150 000 new colorectal cancer patients per year, patients with early cancers and synchronous metastases are excluded, and so there are about 100 000 patients to be followed up. One half of these cancers will recur (50 000); one third of these will have only liver disease (17 000)<sup>2</sup>; one third of these will have resectable hepatic metastases (5500)<sup>3</sup>; and one third of these will be cured (1850).<sup>4,5</sup>Hence, the incremental
Protecting Employees From Heat
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Formulary availability and regulatory barriers to accessibility of opioids for cancer pain in Africa: a report from the Global Opioid Policy Initiative (GOPI)
Authors: J. Cleary, R.A. Powell, G. Munene, F.N. Mwangi-Powell, E. Luyirika, F. Kiyange, A. Merriman, W. Scholten, L. Radbruch, J. Torode, N.I. Cherny
Journal: Annals of Oncology (2013)
Correction
Journal: BMJ (1964)

Drugs~~~~~~~~~~~~~~~R IEDICA JURA with hyperinfection with it.Diagnosis is made on seeing the living larvae in the stools." Telmid " (dithiazanine iodide; 25-or 100-mg.tablets) 100 mg.three times daily for one day, followed by 200 mg.simi- larly for four or more days, may eradicate the infection.The drug stains the stools green or blue ; it may cause nausea, vomit- ing, abdominal cramps, and diarrhoea.Its use is contraindicated in cases of renal disease.
Soil Ingestion: A Concern for Acute Toxicity in Children
Authors: Edward J. Calabrese, Edward J. Stanek, Robert C. James, Stephen M. Roberts
Journal: Environmental Health Perspectives (1997)

Several soil ingestion studies have indicated that some children ingest substantial amounts of soil on given days. Although the EPA has assumed that 95% of children ingest 200 mg soil/day or less for exposure assessment purposes, some children have been observed to ingest up to 25-60 g soil during a single day. In light of the potential for children to ingest such large amounts of soil, an assessment was made of the possibility for soil pica episodes to result in acute intoxication from contaminant concentrations the EPA regards as representing conservative screening values (i.e., EPA soil screening levels and EPA Region III risk-based concentrations for residential soils). For a set of 13 chemicals included in the analysis, contaminant doses resulting from a one-time soil pica episode (5-50 g of soil ingested) were compared with acute dosages shown to produce toxicity in humans in clinical studies or case reports. For four of these chemicals, a soil pica episode was found to result in a contaminant dose approximating or exceeding the acute human lethal dose. For five of the remaining chemicals, the contaminant dose from a soil pica episode was well within the reported dose range in humans for toxicity other than lethality. Because both the exposure episodes and the toxicological response information are derived from observations in humans, these findings are regarded as particularly relevant for human health risk assessment. They suggest that, for some chemicals, ostensibly conservative soil criteria based on chronic exposure using current EPA methodology may not be protective of children during acute soil pica episodes.
National morbidity data have their beginnings in offices of private practice physicians
Authors: T. Randall
Journal: JAMA (1990)

PHYSICIANS become the eyes and ears of the Public Health Service when they report infectious diseases to their state or local health departments. Accurate and timely reporting by physicians in private practice often can mean the difference between a local outbreak and an epidemic, public health officials say. Physicians' fidelity in reporting ranges from "abominable" to exemplary, depending on the disease, CDC epidemiologists say. Although most surveillance programs don't need complete reporting to be useful, underreporting does impair the CDC's ability to monitor short- and long-term trends, alert health care professionals to important changes in these trends, and estimate the magnitude of morbidity and mortality. Emphasizes Steven Teutsch, MD, director of the CDC's Division of Surveillance and Epidemiology: "We are absolutely dependent. Without reports, our hands are tied because we don't know what's going on out there." <h3>States Have Own Preferences</h3> Today, all states and territories participate in a morbidity
Books Received
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Letter: Skull traction for cervical spine injury: should it be abandoned?
Authors: R. B. Cloward
Journal: JAMA (1973)

<h3>To the Editor.—</h3> In the initial report of the National Spinal Cord Injury Registry, statistics related to the treatment instituted were revealed. Drucker and Perot<sup>1</sup>stated that "it may come as a surprise to many neurosurgeons and orthopedic surgeons to find that vertebral fusion is commonly carried out the day of the accident." There were 19 vertebral fusions, ten laminectomies, and 33 tong insertions performed on day 0. It is gratifying to see twice as many anterior operations as laminectomies. The large number treated by skull traction, however, is cause for concern. Treatment of fractures of the cervical spine by skull traction probably does more harm than good. Twenty-five years ago, it was sound surgical teaching and practice to place the part or organ of the body, damaged by injury or operation, at complete rest to obtain proper healing. Following major operations, patients were confined to bed for two
ACETANILID ADDICTION: REPORT OF A CASE
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nouveau traité de médecine.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE "MICROBES" OF RHEUMATISM.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Gene expression profiles of paraffin-embedded core biopsy tissue predict response to chemotherapy in patients with locally advanced breast cancer
Authors: L. Gianni, M. Zambetti, K. Clark, J. Baker, M. Cronin, G. Mariani, J. Rodriguez, M. L. Carcangiu, P. Valagussa, S. Shak
Journal: Journal of Clinical Oncology (2004)

501 Background: Previous studies validated a 21 gene RT-PCR Recurrence Score assay to quantify the likelihood of distant recurrence in node -, ER+, tamoxifen treated patients (pts). Tumor gene expression quantified using these 21 genes and/or other candidate genes may predict the likelihood of chemotherapy response. Methods: Pts with locally advanced breast cancer were treated with doxorubicin (60 mg/m2) and paclitaxel 200 (mg/m2) q 3wk x 3, followed by weekly paclitaxel (80 mg/m2) x 12 before surgery, and adjuvant intravenous CMF q 4wk x 4 thereafter. A high-throughput RT-PCR assay quantified fixed tumor tissue expression of 384 genes selected from literature and previous gene expression studies. Results: Of 93 pts with available biopsy enrolled between 1998 and 2002, 89 pts (97%) had sufficient RNA extracted for analysis. Mean age was 50 yr and median tumor size was 6 cm. Pathologic complete response (pCR) was observed in 11 pts (12.4%). Quantitative gene expression results were obtained for 383 genes. Using univariate analysis, a significant correlation between gene expression and pCR was observed for 87 genes (p<0.05), including 5 with p<0.001 and 30 with p<0.01. 30 of the 87 genes that correlated with pCR clustered by both expression and function into 3 groups—an ER group (e.g., ER, PR, SCUBE2), a proliferation group (e.g. MYBL2, E2F1, MCM6), and an immune group (e.g., CD3z, CD18, FASL). pCR was more likely with lower expression for the ER group and higher expression for the proliferation and immune groups. Multivariate analysis indicates that combinations of genes are more powerful predictors of response than single genes. Notably, pCR was more likely with high Recurrence Score as calculated from a previously defined 21-gene panel, and less likely with low Recurrence Score (p<0.01). Conclusions: RT-PCR analysis of an ER gene cluster predicts pCR to primary chemotherapy, and addition of other genes increases predictive power. These results will be used to define a multi-gene panel for validation in a larger independent study. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Genomic Health, Inc. Genomic Health, Inc. Genomic Health, Inc. Genomic Health, Inc.
IVF Registry notes more centers, more births, slightly improved odds
Authors: C. A. Raymond
Journal: JAMA (1988)

RECENTLY RELEASED data from 41 of the country's estimated 160 in vitro fertilization clinics indicate that the technique's success rate is improving somewhat. In 1986, 485 clinical pregnancies occurred in 3055 women (15.9%), up from 337 pregnancies in 2475 women (13.6%) in 1985 (<i>Fertil Steril</i>1988;49:212-215). Data included in the registry were reported voluntarily by the clinics, so the success rates or numbers of live births at clinics not participating in the registry are unknown. In releasing the data, the American Fertility Society cited overall success rates for 1985 and 1986 as 14.1% and 16.9%, respectively. Those figures are based on the number of clinical pregnancies per embryo transfer, figures which some fertility specialists think may be misinterpreted by patients (<i>JAMA</i>1988;259:464-469). The reason for this is because embryo transfer is the final step in a many-step procedure to achieve pregnancy. Using clinical pregnancies in the numerator and the number
The impact of the acquired immunodeficiency syndrome on patterns of premature death in New York City
Authors: A. R. Kristal
Journal: JAMA (1986)

This report examines the impact of acquired immunodeficiency syndrome (AIDS) on patterns of mortality among persons aged 15 to 64 years in New York City. The New York City AIDS surveillance registry was matched to the New York City vital statistics registry to identify deaths caused by AIDS. In 1984, the AIDS mortality rate per 100,000 persons aged 15 to 64 years was 42.2 for males and 5.3 for females. Analyzed by five-year age groups, AIDS was among the five leading causes of death for males aged 25 to 54 years, and the leading cause of death for males aged 30 to 39 years. For females, AIDS was the fourth leading cause of death for women aged 25 to 29 years, and the second leading cause for women aged 30 to 34 years. Almost 10% of the years of potential life lost to males aged 15 to 64 years was due to AIDS, and for females, 3.6%. For both men and women in the highest-risk age group, 20 to 44 years, blacks and Hispanics had higher mortality rates than Asians or whites. The higher mortality in blacks and Hispanics is believed to be related to a higher prevalence of drug abuse in these populations and not to ethnicity per se. These findings document the enormous increases in premature mortality attributable to AIDS. (<i>JAMA</i>1986;255:2306-2310)
Abstract 1764: Coapsys <sup>®</sup> Leads to Global Reversal of Left Ventricular Remodeling: Expanded TRACE Study Analysis
Authors: Sanjay Mittal, Yugal Mishra, Naresh Trehan
Journal: Circulation (2007)

Background: . We have previously reported as a part of the TRACE study that patients with LV dysfunction undergoing CABG and surgical implantation of Coapsys had significant reductions in LV size and MR at 1 year. Echo data of patients who recieved CABG with and without Coapsys, were retrospectively analyzed to determine the extent and pattern of LV reverse remodeling related to the LV shape change properties of Coapsys. Methods: Coapsys consists of anterior and posterior epicardial pads connected by a flexible chord, drawn together to affect change in valvular and ventricular geometry. Coapsys was implanted in patients whose MR remained ≥ grade 2 after CABG (Coapsys + CABG group, n=32). Patients whose MR grade reduced to 1 or less after CABG (CABG Alone group, n=35) received CABG only. Baseline age, ejection fraction, graft number, and MR grade in the Coapsys + CABG group and the CABG Alone group were 58, 35, 2.7, 3.0 and 59, 37 2.8, 2.7 respectively. Detailed echocardiographic measurements of diastolic left ventricular dimensions in 3 echo planes, 4 Chamber (4 Ch), 2 Chamber (2 Ch), and Long Axis (LAX), along with LV length and anterolateral papillary muscle (ALPM) depth were serially collected up to 12 months after surgery. Results: Comparison of baseline, 3 month and 12 month dimensions between Coapsys + CABG and CABG Alone groups are displayed in Figure 1 . Conclusions: In patients with MR and LV dysfunction undergoing implantation of Coapsys along with CABG, there is significant, global and progressive reversal of LV remodeling. This may to be related to the LV shape change properties of Coapsys and could benefit patients with heart failure.
Questions and Answers
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Relationship of Daily Mortality to Suspended Particulates in Santa Clara County, 1980-1986
Authors: David Fairley
Journal: Environmental Health Perspectives (1990)

This paper explores the relationship between daily mortality and suspended particulates in Santa Clara County, CA, for years 1980 to 1986. An association was found between high particulate concentrations and increased mortality. This association persists after adjustment for temperature, relative humidity, year, and seasonality. Contrary to expectation, the magnitude of the particulate effect appears the same or larger than that estimated for London, despite Santa Clara County's cleaner air. The persistence of an effect at these lower particulate concentrations suggests that the particulate variable may be acting as a surrogate for some constituent particles, such as acid aerosols.
Appendicitis.
Authors: W. F. Sterman
Journal: JAMA (1897)

Evansville, Ind., Dec. 3, 1897. <h3>To the Editor:</h3> —The alarming mortality rate following operative measures for the cure of appendicitis in this city has caused considerable comment of a questionable nature, recently and in the daily papers this morning the Board of Health has taken the matter into consideration. A recent case of operation during convalescence, and the patient's death in less than thirty-six hours, has opened the way to adverse criticism. In the case mentioned the operation seems to have been done through jealous rivalry, with a large fee as an incentive, which only too plainly demonstrates the fact that the surgeon above all others should be a man of unbiased mind. During my twenty-six months of hospital work in Louisville, Chicago and this city, I have carefully observed the medical and surgical diagnosis and treatment of this disease and noted the difficulty in differentiating between it and typhlitis,
Public Views on Healthcare Performance Indicators and Patient Choice
Authors: Helen Magee, Lucy-Jane Davis, Angela Coulter
Journal: Journal of the Royal Society of Medicine (2003)

Patients on certain waiting lists in the UK National Health Service (NHS) are now offered the choice of persevering with their home hospital or switching to another hospital where they will be treated on a guaranteed date. Such decisions require knowledge of performance. We used facilitated focus groups to investigate the views of patients and members of the public on publication of information about the performance of healthcare providers. Six groups with a total of 50 participants met in six different locations in England. Participants felt that independent monitoring of healthcare performance is necessary, but they were ambivalent about the value of performance indicators and hospital rankings. They tended to distrust government information and preferred the presentational style of ‘Dr Foster’, a commercial information provider, because it gave more detailed locally relevant information. Many participants felt the NHS did not offer much scope for choice of provider. If public access to performance information is to succeed in informing referral decisions and raising quality standards, the public and general practitioners will need education on how to interpret and use the data.