Rejuvenation in Older Adults Receiving Oral Ghrelin
Authors: Hernando Rafael
Journal: Annals of Internal Medicine (2009)

Letters5 May 2009Rejuvenation in Older Adults Receiving Oral GhrelinHernando Rafael, MDHernando Rafael, MDFrom Universidad Nacional Autónoma de México, 03300 Mexico City, Mexico.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-150-9-200905050-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I read with interest the article by Nass and colleagues (1), which presents clinical evidence of rejuvenation in 65 healthy older adults (men and women) 60 to 81 years of age after daily administration of oral ghrelin (a secretagogue product) for 1 year. Oral administration of MK-677 increased pulsatile growth hormone secretion and serum insulin-like growth factor (IGF)–I (also known as somatomedin C) levels (2). In part, I agree with Nass and colleagues' findings, because through blood flow, the growth hormone secretagogues (comprising amino acids, some peptides, vitamins, and minerals) may reach the producing hypothalamic nuclei of ...References1. Nass R, Pezzoli SS, Oliveri MC, Patrie JT, Harrell FE, Clasey JL, et al. Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial. Ann Intern Med. 2008;149:601-11. [PMID: 18981485] LinkGoogle Scholar2. Chapman IM, Bach MA, Van Cauter E, Farmer M, Krupa D, Taylor AM, et al. Stimulation of the growth hormone (GH)-insulin-like growth factor I axis by daily oral administration of a GH secretogogue (MK-677) in healthy elderly subjects. J Clin Endocrinol Metab. 1996;81:4249-57. [PMID: 8954023] MedlineGoogle Scholar3. Rafael H. Rejuvenation after omental transplantation on the optic chiasma and carotid bifurcation. Case Rep Clin Pract Rev. 2006;7:48-51. Google Scholar4. Rafael H. Hypothalamic ischemia and premature aging [Letter]. Med Sci Monit. 2007;13:LE9-10. [PMID: 17599033] MedlineGoogle Scholar5. García-Gómez I, Goldsmith HS, Angulo J, Prados A, López-Hervás P, Cuevas B, et al. Angiogenic capacity of human omental stem cells. Neurol Res. 2005;27:807-11. [PMID: 16354540] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Hernando Rafael, MDAffiliations: From Universidad Nacional Autónoma de México, 03300 Mexico City, Mexico.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoEffects of an Oral Ghrelin Mimetic on Body Composition and Clinical Outcomes in Healthy Older Adults Ralf Nass , Suzan S. Pezzoli , Mary Clancy Oliveri , James T. Patrie , Frank E. Harrell Jr. , Jody L. Clasey , Steven B. Heymsfield , Mark A. Bach , Mary Lee Vance , and Michael O. Thorner Rejuvenation in Older Adults Receiving Oral Ghrelin Markus Gaugg Rejuvenation in Older Adults Receiving Oral Ghrelin Jim Webster Rejuvenation in Older Adults Receiving Oral Ghrelin Ralf M. Nass , Mary Lee Vance , and Michael O. Thorner Metrics 5 May 2009Volume 150, Issue 9Page: 653-654KeywordsBlood flowElderlyGhrelinGrowth hormoneInsulin-like growth factorsOxygenPeptide hormonesRevascularizationStem cellsVitamins ePublished: 5 May 2009 Issue Published: 5 May 2009 Copyright & PermissionsCopyright © 2009 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...