Extended-Duration Venous Thromboembolism Prophylaxis for Medical Patients
Authors: Francesco Dentali, Monica Gianni, Alessandro Squizzato
Journal: Annals of Internal Medicine (2010)

Letters16 November 2010Extended-Duration Venous Thromboembolism Prophylaxis for Medical PatientsFrancesco Dentali, MD, Monica Gianni, MD, and Alessandro Squizzato, MDFrancesco Dentali, MDFrom University of Insubria, 21100 Varese, Italy.Search for more papers by this author, Monica Gianni, MDFrom University of Insubria, 21100 Varese, Italy.Search for more papers by this author, and Alessandro Squizzato, MDFrom University of Insubria, 21100 Varese, Italy.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-153-10-201011160-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In the large randomized, controlled trial (RCT) by Hull and colleagues (1), extended-duration prophylaxis with subcutaneous enoxaparin compared with short-duration prophylaxis reduced the incidence of the primary efficacy end point (the composite of symptomatic or asymptomatic deep venous thrombosis, symptomatic pulmonary embolism, or fatal pulmonary embolism) in patients requiring total bed rest or who were sedentary without bathroom privileges, patients older than 75 years, and women. In contrast, the primary safety end point (major hemorrhagic complications during and up to 48 hours after the double-blind treatment) was significantly greater in the extended-duration enoxaparin group than in the ...References1. Hull RD, Schellong SM, Tapson VF, Monreal M, Samama MM, Nicol P, et al. EXCLAIM (Extended Prophylaxis for Venous ThromboEmbolism in Acutely Ill Medical Patients With Prolonged Immobilization) study. Extended-duration venous thromboembolism prophylaxis in acutely ill medical patients with recently reduced mobility: a randomized trial. Ann Intern Med. 2010;153:8-18. [PMID: 20621900] LinkGoogle Scholar2. Rasmussen MS, Jorgensen LN, Wille-Jørgensen P, Nielsen JD, Horn A, Mohn AC, et al; FAME Investigators. Prolonged prophylaxis with dalteparin to prevent late thromboembolic complications in patients undergoing major abdominal surgery: a multicenter randomized open-label study. J Thromb Haemost. 2006;4:2384-90. [PMID: 16881934] CrossrefMedlineGoogle Scholar3. Eikelboom JW, Quinlan DJ, Douketis JD. Extended-duration prophylaxis against venous thromboembolism after total hip or knee replacement: a meta-analysis of the randomised trials. Lancet. 2001;358:9-15. [PMID: 11454370] CrossrefMedlineGoogle Scholar4. Geerts WH, Bergqvist D, Pineo GF, Heit JA, Samama CM, Lassen MR, et al; American College of Chest Physicians. Prevention of venous thromboembolism: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest. 2008;133:381S-453S. [PMID: 18574271] CrossrefMedlineGoogle Scholar5. Dentali F, Douketis JD, Gianni M, Lim W, Crowther MA. Meta-analysis: anticoagulant prophylaxis to prevent symptomatic venous thromboembolism in hospitalized medical patients. Ann Intern Med. 2007;146:278-88. [PMID: 17310052] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From University of Insubria, 21100 Varese, Italy.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoMeta-analysis: Anticoagulant Prophylaxis to Prevent Symptomatic Venous Thromboembolism in Hospitalized Medical Patients Francesco Dentali , James D. Douketis , Monica Gianni , Wendy Lim , and Mark A. Crowther Extended-Duration Venous Thromboembolism Prophylaxis in Acutely Ill Medical Patients With Recently Reduced Mobility Russell D. Hull , Sebastian M. Schellong , Victor F. Tapson , Manuel Monreal , Meyer-Michel Samama , Philippe Nicol , Eric Vicaut , Alexander G.G. Turpie , Roger D. Yusen , and Extended-Duration Venous Thromboembolism Prophylaxis for Medical Patients Jose A. Nieto , Reina Valle , and Juan B. Lopez-Saez Extended-Duration Venous Thromboembolism Prophylaxis for Medical Patients Michael P. Carson and Yen-Hong Kuo Extended-Duration Venous Thromboembolism Prophylaxis for Medical Patients Russell D. Hull and Metrics 16 November 2010Volume 153, Issue 10Page: 688KeywordsDeep vein thrombosisFearHemorrhageMedical risk factorsOrthopedicsProphylaxisPulmonary embolismSafetyVenous thromboembolism ePublished: 16 November 2010 Issue Published: 16 November 2010 Copyright & PermissionsCopyright © 2010 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...