tbuckley/cabot-search huggingface dataset:
Breast cancer molecular profiles and tumor response of neoadjuvant doxorubicin and paclitaxel: The I-SPY TRIAL (CALGB 150007/150012, ACRIN 6657)
Authors: L. J. Esserman, C. Perou, M. Cheang, A. DeMichele, L. Carey, L. J. van 't Veer, J. Gray, E. Petricoin, K. Conway, N. Hylton, D. Berry
Journal: Journal of Clinical Oncology (2009)

LBA515 Background: I-SPY is a multi-center trial designed to identify predictive markers of pathological complete response (pCR) and survival of women with locally advanced breast cancers (3cm or greater). Women received neoadjuvant doxorubicin and cyclophosphamide then paclitaxel. Methods: 237 women enrolled, 216 completed serial imaging and core biopsies. Pre-treatment assays include: Agilent expression arrays, MIP aCGH, p53 gene chip and sequencing, IHC and reverse phase protein arrays (RPMA). Response to therapy was measured by serial MRI, pCR and residual cancer burden (RCB). Associations among molecular markers, pCR, RCB and survival were evaluated using chi-square test, Kaplan-Meier curves and log-rank test. Results: Median tumor size was 6cm, % pCR and RCB 0/1 was 27% and 36% for the entire study; % pCR rate for the 144 Agilent arrays was 25%. Distribution, rates of pCR and RCB 0/1 are shown in the Table for molecular and IHC markers. DFS and OS will be presented. Several molecular subtypes, including NKI 70 gene low, luminal A, 21 gene set low and IHC HR+, define 15–28% of patients with 3–10% pCR, yet excellent early survival. Wound healing, most discriminatory for prognosis, is not predictive of chemotherapy response. By RPMA, patients with pCR had increased phosphorylation of 4EBP1, eNOS, cAbl, STAT5, EGFR, AKT (p&lt;0.05). In ER+ patients with poor MR response, pIRS, pIGFR, p706S were activated (p&lt;0.05). RCB is a more refined way to measure pCR and was more predictive of DFS and OS (p=0.01) than pCR alone with a mean follow up of 3.9 years. MR volume is highly predictive of pCR and RCB. For specific subtypes, e.g. basal, RCB is predictive of DFS (p&lt;0.00001). Conclusions: LABC have aggressive biology. Response to therapy and outcome can be predicted by many biomarkers. The I-SPY data set provides a platform to compare, contrast and combine marker signatures to tailor therapy and demonstrates the power of the neoadjuvant setting. Support: ACRIN U01 CA079778 ; CALGB CA31964, CA33601; NCI SPORE CA58207. [Table: see text] [Table: see text]
Can mammographic parenchymal patterns foretell breast cancer?
Authors: W. Check
Journal: JAMA (1980)

Results of two recent studies challenge the value of breast parenchymal patterns as seen on mammography for predicting development of breast cancer in healthy women. But John Wolfe, MD, the radiologist who originally proposed that breast parenchymal patterns are related to risk of subsequent breast cancer, questions whether the investigators involved correctly classified the mammograms. It is important to determine the accuracy of the Wolfe classification scheme in predicting the development of breast cancer in healthy women, since it appears that a sizeable number of physicians already use this system to determine frequency of follow-up mammograms. At least one group in addition to Wolfe's even recommends prophylactic mastectomies on the basis of the patterns (see also pp 287-288). Accordingly, one group of radiologists has begun a long-term, prospective, multi-institutional study to test the predictive value of the system. Wolfe, who is chief of radiology at Hutzel Hospital, Detroit, and clinical
Alvin Novick
Journal: BMJ (2005)

In 1982, when the AIDS epidemic was in its infancy, it took an unusually prescient person to recognise that this was a disease like no other.One such person was Alvin Novick, professor of biology at Yale University and a former clinician.The term AIDS had only just been coined.President Reagan had not mentioned the word in public (that took him a further three years), though his press secretary had joked about AIDS in a press briefing.The virus had yet to be identified; the first AIDS drug, AZT (zidovudine), was not to reach the marketplace for another five years.Alvin Novick, then aged 58, ended his 30 year study of bat sonar systems to confront the crisis.He ceased doing laboratory science and devoted the rest of his life-a further 20 years-to tackling AIDS.Insightful, decisive, compassionate, and rigorous in everything he did, Novick was ahead of his time on almost every issue.From the beginning, he pressed for safeguards at blood banks.He researched the legal, ethical, public policy, and community development aspects of HIV/AIDS, and he was interested in every aspect of the disease, including AIDS education and prevention; risk reduction for people who injected drugs; the ethical issues surrounding ethnographic research; surveillance; confidentiality; testing; the conduct of clinical trials; tuberculosis and AIDS; the behavioural epidemiology of AIDS; and home and terminal care for patients-he founded Connecticut's AIDS hospice.Novick wanted drug users included in clinical trials, not least to enhance their access to health care.He also researched post-exposure prophylaxis, the use of law to regulate behaviour, the systematic oppression of people who were vulnerable to AIDS infection or were infected; drug adherence; and vertical transmission.
Human Rabies—New York, 1993
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
NOT A " NEW " RULING.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical Lectures on Certain Diseases of the Nervous System.
Authors: None N. S. D.
Journal: JAMA (1889)

These lectures are not very closely related in their subjects to one another and are not by any means exhaustive. They are interesting and instructive and worthy of a careful reading. The subjects of the several lectures are: Spiritism and Hysteria; Isolation in the Treatment of Hysteria; Choreiform Movements and Tremblings; Rhythmical Chorea; Muscular Atrophy consequent on Certain Articular Lesions; Contractions of Traumatic Origin; Painless Tic of the Face in an Hysterical Patient; Muscular Atrophy Consecutive to Articular Rheumatism; Six Cases of Hysteria in the Male Subject.
BOOK REVIEWS
Authors: H. S. SMITH
Journal: JNCI Journal of the National Cancer Institute (1989)

Journal Article BOOK REVIEWS Get access Breast Cancer: Cellular and Molecular Biology. Marc E. Lippman, Robert B. Dickson, eds. Dordrecht, The Netherlands: Kluwer Academic Publishers, 1988, 397 pp. $117.50. HELAN S. SMITH HELAN S. SMITH Peralta Cancer Research Institute3023 Summit St. Oakland, CA 94609 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 81, Issue 7, 5 April 1989, Page 540, https://doi.org/10.1093/jnci/81.7.540 Published: 05 April 1989
High-Risk Sexual Behavior by HIV-Positive Men Who Have Sex With Men—16 Sites, United States, 2000-2002
Journal: JAMA (2004)

The majority of persons living with human immunodeficiency virus (HIV) in the United States are men who have sex with men (MSM). High-risk sexual behavior by HIV-positive MSM exposes sex partners to HIV. The risk for transmitting HIV from an infected partner to an uninfected partner through unprotected insertive anal intercourse (UIAI) is greater than the risk for transmission through receptive anal intercourse or oral sex. Differences in sexual risk behavior might be associated with the perceived HIV serostatus of the partner (i.e., HIV positive, HIV negative, or unknown serostatus), as well as with the sex partner type (i.e., steady or nonsteady). During May 2000-December 2002, HIV-positive MSM were interviewed in a behavioral surveillance survey at surveillance sites in 16 states. This report describes insertive anal intercourse practices reported by these MSM; findings indicated that a large percentage of HIV-positive MSM were sexually abstinent, practiced safer sexual behavior by having protected insertive anal intercourse, or had UIAI with an HIV-positive partner. However, a small percentage of HIV-positive MSM reported UIAI with partners who were HIV negative or whose serostatus was unknown; for this group, more intensive and comprehensive HIV-prevention efforts are needed to eliminate this risk behavior.
Dr. Cook and Colleagues Reply
Authors: J. A. COOK, L. A. RAZZANO, J. K. BURKE-MILLER, S. A. PICKETT-SCHENK, D. D. GREY, A. F. LEHMAN, W. R. McFARLANE, P. B. GOLD, H. S. LEFF, C. BLYLER,, M. G. TOPRAC, L. BLANKERTZ, M. SHAFER
Journal: American Journal of Psychiatry (2006)
Max Rubner
Authors: E. Guensberg
Journal: JAMA (1966)

<h3>To the Editor:—</h3> I read with great interest your editorial about Max Rubner (<b>194</b>:86, 1965) because I was a pupil of his at the University of Berlin in 1927 and 1928. Although retired in 1924, he was asked to occupy the chair of physiology after Hoffman's death, until a new incumbent could be found. It was during this period that I had the good fortune to study under him. Your article recognized him as the leader in the field of metabolism of foodstuffs. He was also the father of a new branch in physiology, the Physiology of Nutrition, because it was he who established the caloric values for the three nutrients, as you quoted, and also degrees grees of their interchangeability in nthe body metabolism. The protein minimum and protein optimum, the conversion of carbohydrates into fat, the ideal combustion of fat in the presence of carbohydrates, these and
Rational diet construction for mild and grand obesity
Authors: I. F. Tullis
Journal: JAMA (1973)

Rational diet construction for obesity requires understanding of two facts: (1) energy expenditure must be considered along with diet and (2) psychological incentive must be maintained. Ironically, time may prove that diet construction in the present day sense will play a minor role in obesity correction. It has become progressively more apparent that psychological and behavioral characteristics of the individual represent the true etiological factors in obesity. Correction of these depends on successful behavior modification of the individual. The best current concept is that diet and exercise are fundamental for obesity control, but also that behavior modification is the underlying essential for long-term regulation. Physiologically and psychologically, mild and grand obesity are different. In mild obesity the problem is usually one of insidious, often slight shift of caloric balance to one beyond weight maintenance over a prolonged period. Dietary intake and energy expenditure are both usually involved in the change
Video Comment on Gian Eugenio Tontini et al., pages 437–443
Journal: Endoscopy (2015)

See also: Confocal laser endomicroscopy for the differential diagnosis of ulcerative colitis and Crohn’s disease: a pilot studyEndoscopy 2015; 47(05): 437-443DOI: 10.1055/s-0034-1391226
THE CONTINUED USE OF DIGITALIS IN PATIENTS WITH REGULAR RHYTHM
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Guido Majno, MD: raconteur of medical lore
Authors: C. Macek
Journal: JAMA (1982)

It all started with a leisurely one-week perusal of the literature on blood vessels. Next thing he knew, it was a 20-year project tracing the history of wound healing. It could only happen to someone who finds the history of medicine as fascinating as the practice of it. "I think there is a link between pathology and history—they're both about mechanisms," says Guido Majno, MD, chairman of pathology at the University of Massachusetts Medical School in Worcester and author of the former Book-of-the-Month Club offering,<i>The Healing Hand</i>, published in 1975 (Harvard University Press, Cambridge). "Many historians of medicine were pathologists, and if you're interested in mechanisms you become a pathologist." Majno's desire to understand why and how medicine evolved led him to original manuscripts from the ancient civilizations of Greece, Rome, Egypt, China, India, and Iran, among others. Because of this, reading<i>The Healing Hand</i>is like going through
THROW AWAY THE PINCH BAR!
Journal: JAMA (1961)

The USE of staples in the binding of 250 or more pages of each issue ofThe Journalinsured an intact copy upon delivery in former years. The book remained securely bound for as long thereafter as the reader permitted. The stapling machine left nothing to chance; it performed an expert technical job. If an Original Communication, a Special Contribution, or selected abstracts held a special attraction and seemed appropriate for removal and filing for ready retrieval, a major maneuver was necessary. The removal of staples was not possible with standard desk equipment. The most effective attack required a 14-inch screw driver with a wide head (a pinch bar was even better) and heavy-duty pliers. The second step required a surgeon's scalpel or a safety razor blade, the latter at the risk of laceration of a finger or a thumb. Not all physicians have scalpels available, and not many physicians
Sequential Trial of Nonthermal Effect of Atmospheric Humidity on Survival of Newborn Infants of Low Birth Weight
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MISSISSIPPI VALLEY MEDICAL ASSOCIATION.
Authors: Hanau W Loeb
Journal: JAMA (1884)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Analysis of Polychlorinated Dibenzofurans, Dioxins and Related Compounds in Environmental Samples
Authors: Hans-Rudolf Buser, Christoffer Rappe, Per-Anders Bergqvist
Journal: Environmental Health Perspectives (1985)

The analysis of polychlorinated dibenzofurans (PCDFs), dibenzo-p-dioxins (PCDDs) and to some extent biphenylenes (PCBPs) by high-resolution gas chromatography (HRGC) and mass spectrometry is described. Electron-impact (EI) and negative chemical ionization (NCI) mass spectrometry were used, and their application in environmental analyses documented. NCI shows increased sensitivity to all PCDFs and PCDDs except for 2,3,7,8- and other tetra-CDD isomers. The identification of the various PCDFs and PCDDs, specifically the identification of the toxic and hazardous 2,3,7,8-substituted isomers is emphasized; the unambiguous identification of all 2,3,7,8,-substituted PCDDs is documented. The application of HRGC and mass spectrometry to isomer-specific analyses of samples of aquatic species from the Baltic and the Great Lakes is shown. Results from this and previous studies indicate PCDF and PCDD residues in these organisms including significant levels of 2,3,7,8-substituted isomers. These aquatic species apparently show preferential retention or reduced metabolization rates for these toxic isomers. The results of samples from the Baltic indicate a contamination primarily due to PCDFs. The origin of this contamination seems complex and related to PCBs as well as chlorophenols. PCDF and PCDD isomer distribution patterns from analyses using HRGC and mass spectrometry aid in the identification of origin, sources and elucidation of routes of formation of these compounds. These methods are indispensable in taking measures to reduce future contaminations and to protect our environment.
Recognition and management of discord within house staff teams
Authors: M. S. Jellinek
Journal: JAMA (1986)

A WELL-FUNCTIONING house staff team is essential to inpatient care and teaching. The skills of working together and team management are not taught directly but are handed down through the house staff or learned by identification with members of the faculty. Although these indirect methods of teaching are often sufficient, they do not address important affective issues such as team morale or interpersonal tension. Under stressful circumstances the level of tension within a team can rise, causing individuals to feel angry and impairing the team's ability to function. The observations presented in this study are based on numerous consultations to intensive care and other teams in distress and weekly rounds that have included approximately 100 senior pediatric residents leading teams. House staff teams commonly try to avoid acknowledging when stress or interpersonal tensions become discord. Often, conflict can be a well-kept secret. Although nursing staff are aware of the hostility