tbuckley/cabot-search huggingface dataset:
Effects of Chrysotile on a Lysosomal Enzyme Preparation and on the Hydrolytic Enzyme Activity of Cultured Alveolar Macrophages
Authors: R. Desai, R. J. Richards
Journal: Environmental Health Perspectives (1983)

The interaction between chrysotile and three lysosomal enzymes (acid phosphatase, acid RNase and acid protease) in isolated lysosomal enzyme-rich preparations (LEP), from sheep alveolar macrophages maintained in the presence and absence of serum components or pulmonary surfactant at pH 5.0 and pH 7.0 for up to 22 days, is investigated. It is concluded that chrysotile does not inhibit or enhance lysosomal enzyme activity at either pH but may preferentially absorb specific enzymes and that the binding reaction between any given enzyme and mineral can be dependent on the presence of other organic compounds. The release of three hydrolytic enzymes (beta-galactosidase, acid RNase and protease) from cultured rabbit alveolar macrophages, in the presence of different concentrations of bovine serum (5-20%) and in the presence and absence of chrysotile for 72 hr, was also studied. Chrysotile enhances early differential release of each hydrolytic enzyme, but after 72 hr both control and chrysotile-treated cultures (maintained in 10-20% serum) have very similar intra- and extracellular levels of hydrolytic activity. The apparent differential release of lysosomal enzymes by untreated macrophages, which is dependent on serum concentration and time in vitro, is discussed.
Dietary Supplements
Authors: Mike Mitka
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Staging procedures, clinical management, and survival outcome for ovarian carcinoma
Authors: R. Hand
Journal: JAMA (1993)

<h3>Objective.</h3> —To evaluate the relationship between survival and patterns of clinical management for ovarian carcinoma. <h3>Design.</h3> —Retrospective analysis of cancer registry data including follow-up, operative reports, and pathology reports. <h3>Setting.</h3> —Seventy-seven Illinois hospitals with active cancer registries. <h3>Patients.</h3> —A total of 2669 women with newly diagnosed ovarian carcinoma from 1983 through 1988. <h3>Main Outcome Measures.</h3> —Frequency of use of specific staging procedures and treatment options. Survival was estimated using the Kaplan-Meier product-limit method. <h3>Results.</h3> —Thirty percent of 632 stage I patients, 31% of 233 stage II patients, and 45% of 516 stage III patients underwent hysterectomy, bilateral salpingooophorectomy, omentectomy, sampled peritoneal washings, and node biopsy. Five-year survival for those receiving this extensive surgery (who were therefore pathologically staged) was as follows: stage I, 80%; stage II, 63%; and stage III, 28%. For those not receiving this extensive surgery (who were therefore clinically staged), the 5-year survival at these stages was 76%, 62%, and 21%, respectively. The overall survival curves were not significantly different between those who were pathologically staged and those who were clinically staged forstage I patients (<i>P</i>=.27) or stage II patients (<i>P</i>=.47), but were for stage III patients (<i>P</i>=.01). Platinum-based combination chemotherapy was given to 76% of 221 patients with pathological stage III disease. Their 5-year survival—50% for the group with no residual disease and 20% for the group with residual disease—was better than for those receiving regimens without platinum—37% and 5%, respectively, for the two groups—and the overall survival curves were significantly better for those receiving platinum (<i>P</i>&lt;.0005 for both groups). The groups receiving platinum had younger patients. <h3>Conclusions.</h3> —Extensive surgery for pathological staging was not usually done for management of ovarian cancer, while platinum-based chemotherapy was commonly used. Failure to undergo extensive surgery had little impact on survival for stage I and II patients. However, use of extensive surgery and platinum-based chemotherapy improved survival for stage III patients. The improved survival for this group receiving platinum-based chemotherapy may be explained in part by selection of younger patients for this treatment. (<i>JAMA</i>. 1993;269:1119-1122)
Trouble
Authors: BM Rodriguez
Journal: Annals of Internal Medicine (2000)

Ad Libitum1 August 2000TroubleBeatriz M. Rodriguez, MDBeatriz M. Rodriguez, MDRockford, IL 61114 (Rodriguez)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-133-3-200008010-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The trouble is they stop you, they ... Author, Article, and Disclosure InformationAuthors: Beatriz M. Rodriguez, MDAffiliations: Rockford, IL 61114 (Rodriguez)Corresponding Author: Beatriz M. Rodriguez, MD, Rockford Memorial Hospital, 2300 North Rockton, Rockford, IL 61114. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 2000Volume 133, Issue 3 Page: 217 Keywords Coffee Emotions Intensive care units Interleukins Memory Touch ePublished: 15 August 2000 Issue Published: 1 August 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
A Stitch in Time
Authors: Jennifer A Best
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lymphadenopathy associated with severe hypertriglyceridemia
Authors: D. A. Leaf
Journal: JAMA (1990)

The clinical recognition of diffuse lymphadenopathy generates a variety of important differential diagnostic considerations. We describe a woman with severe hypertriglyceridemia (type V hyperlipidemia) associated with diffuse lymphadenopathy. This association has not been described previously and should be included in the differential diagnosis of diffuse lymphadenopathy. (<i>JAMA</i>. 1990;264:727-728)
Tauro α-muricholate is as effective as tauro β-muricholate and tauroursodeoxycholate in preventing taurochenodeoxycholate-induced liver damage in the rat
Authors: K Kitani
Journal: Hepatology (1994)

Male Wistar rats were infused intravenously with taurochenodeoxycholate (0.4 μmol/min/100 gm) alone (group A) or with one of the three bile salts (tauroursodeoxycholate [group B], tauro β-muricholate [group C] or tauro α-muricholate [group D]) at a rate of 0.2 μmol/min/100/gm for 1 hr. One-hour bile flow and bile salt excretion rates were significantly lower in group A than in the other three coinfused (B, C, D) groups. Biliary 1-hr outputs of lactate dehydrogenase and albumin in the bile, on the other hand, were significantly higher in group A than in the other groups. Plasma concentrations of lactate dehydrogenase at the time of killing (1 hr) were two to three times higher in group A than in the other groups. Although tauro α-muricholate does not possess a 7β-hydroxy group, the 6β-hydroxy group that tauro α-muricholate possesses thus appears to be as effective as a 7β-hydroxy group in reducing the liver damage caused by toxic bile salts such as taurochenodeoxycholate. The so-called hepatoprotective effects of tauroursodeoxycholate and tauro β-muricholate found in previous studies may require explanation(s) other than the presence of a 7β-hydroxy group in their molecular structures. (HEPATOLOGY 1994;19:1007–1012.)
Behavior of Mercury in the Body.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Invasive lobular carcinoma (ILC) “classic type”: Distinct clinical features
Authors: A. M. Gonzalez-Angulo, S. W. Kau, K. Broglio, A. U. Buzdar, R. L. Theriault, V. Valero, N. Sneige, D. Frye, G. N. Hortobagyi, M. Cristofanilli
Journal: Journal of Clinical Oncology (2004)

663 Background: classic ILC represents 5–10% of all primary breast cancers (BC). Its histological growth pattern makes early diagnosis, staging and surgical approach difficult. Induction chemotherapy (IC) is used to downstage tumors and facilitate breast conservative surgery. It also provides in-vivo information of chemo-sensitivity. Pathologic complete response (pCR) is an important prognostic factor that predicts for recurrence free survival (RFS) and overall survival (OS). We retrospectively analyzed the impact of histology on response to IC and long-term outcome. Methods: 1034 patients (pts) with stage II and III BC participated in six clinical trials using IC at M.D. Anderson Cancer Center between 1985 and 2002. One hundred and twenty-two patients (12%) had ILC and 912 (88%) had IDC. All pts received anthracycline-based chemotherapy and 246 pts (23.8%) also received a taxane. pCR was defined as no evidence of invasive BC in the breast and axillary lymph nodes. A chi-square test was used assess the association of pCR and histology. The stratified log-rank test was used to assess differences between OS and RFS among the groups and after adjustments for hormone receptor (HR) status, stage, and pCR. Results: Median (med) age of pts was 48 years (yrs), (range 18–79). The lobular group tended to be older (med, 53 vs. 47 yrs), have more HR positive tumors, (92% vs. 62%) lower nuclear grade (16% vs. 56% grade 3), and higher stage at diagnosis (10% vs. 0% were IIIB and IIIC). Pts with ILC achieved pCR less frequently than IDC (3% vs. 15%) and had larger number of involved lymph nodes (LN) at surgery (41% vs. 26% had > 3 LN). At a med follow up of 70 months, pts with ILC tended to have longer RFS, (p=0.004) and longer OS, (p=0.001). These differences persisted after adjustment for HR status (p=0.02 and 0.03) and stage (both p=0.04). Conclusion: ILC is a distinct histological type of breast cancer characterized by better outcome when compared to IDC in spite of the low pCR rate after IC. Additional investigation should clarify the biological features of this disease. The role of primary hormonal therapy should be assessed in ILC. No significant financial relationships to disclose.
Parathyroid hormone alone is as effective as combination in treating osteoporosis
Journal: BMJ (2003)

We have reported that individual clinicians are not as influenced by the presentation of risk in population terms as they are by relative risk (Heller et al, submitted for publication), while others have found that the "number needed to treat" statistic (which also relies on measures of absolute risk) is poorly understood by doctors and lay people. 29 30 It remains for us to examine whether new measures of population impact like PIN-ER-t can be more easily understood and used in health policy related decision making than traditional methods of communicating risk.We are developing a research programme to explore this further.Contributors and sources: The authors work at the Evidence for Population Health Unit, aiming to develop a public health counterpart to evidence based medicine.The measure described here is one of a series of population impact measures developed to use evidence combined with routinely collected data to provide local context to measures of risk and benefit and support public health policy decision making.
Coronary Artery Calcification is Inversely Related to Bone Mineral Density in Young Women:
Authors: Pamela J Schreiner, Cora E Lewis, Robert C Detrano, Stephen B Hulley
Journal: Circulation (2001)

0003 Coronary artery calcification (CAC), a marker of subclinical atherosclerosis, is related to low bone mineral density (BMD) in postmenopausal women, potentially due to age or declining estrogen levels. Little is known about this association in premenopausal women. During the Year 10 CARDIA Study, BMD was measured by dual energy X-ray absorptiometry at the hip (pelvis, femoral neck, intertrochanteric (IT) region, Ward’s triangle) and the lumbar spine in a subgroup; CAC was measured in a different subgroup by electron beam tomography within the same year. A calcium score was calculated as the product of an area of potential calcification covered by 6 adjacent pixels and the peak CT number within that region; a calcium score &gt;0 indicates the presence of any CAC. Data for both measures were available for 75 women, ages 29-41 years (mean age 35 years). CAC was present in 14.7% of these young women. Mean weight was 75.2±19.1 kg, range 48.6 to 124.4 kg. Mean areal BMD was consistent with the age and reproductive status of these women: 1.18, 0.89, 1.15, and 0.83 g/cm 2 for the pelvis, femoral neck, IT region and Ward’s triangle, respectively; and 1.09 g/cm 2 for the lumbar spine. Cross-sectional logistic regression was performed to determine the crude association between BMD and CAC. BMD was not related to CAC at any site. Weight, however, was strongly associated with CAC, with a prevalence odds ratio (pOR) of 2.53 (95% CI 1.43, 4.49) for a 1-sd increment in weight. When weight was considered as a confounder to the association between BMD and CAC, BMD in the IT region was inversely related to CAC, with a 1-sd (0.17 g/cm 2 ) decrement in the IT region BMD associated with a 233% increase in the odds of CAC (pOR=3.33, 95% CI 1.08, 10.4). This association was not materially affected by adjustment for age, ethnicity, or height. Nearly identical results were seen for CARDIA men, with an inverse association between IT region BMD and CAC after adjustment for weight. These data suggest that in a population-based group of young women with low prevalence of either osteopenia or osteoporosis, lower BMD may be a marker of subclinical atherosclerosis, comparable to findings in postmenopausal women.
Medical ethics
Authors: R. M. Veatch
Journal: JAMA (1984)

Developments in medical ethics in the past year imply that an important shift is taking place. While once the critical controversies in medical ethics dealt with personal problems faced by patients or health professionals, the ethics of medicine must now be essentially social. The central and controversial issues involve complex social, political, and economic relationships and the increasing lay involvement in medical-ethical decision making. In March 1983, the President's Commission for the Study of Ethical Problems in Medicine and Biomedical and Behavioral Research issued its final reports.<sup>1</sup>The commission, an interdisciplinary body that included representation from the fields of medicine, nursing, sociology, law, and ethics and from the lay population, has now completed the first major systematic public assessment of the social and ethical policies affecting medical decision making in our society. That same month, it issued what was probably the most important of its reports—the comprehensive, authoritative assessment
Archives of Ophthalmology, Chicago
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Manual of Childbed Nursing, with Notes on Infant Feeding.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE DOCTOR IN POLITICS.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Testicular neoplasm in identical twins. A case report
Authors: M. Zevallos
Journal: JAMA (1983)

THE SIMULTANEOUS and/or subsequent occurrence of neoplasms of a given organ system in twins is an uncommon event. The most frequently reported sites are the hematopoietic tissues, soft-tissue sarcomas, Wilms' tumor, glial tumors, and melanomas. In addition there are other well-defined familial syndromes associated with neoplasia. We report the discovery and treatment of ipsilateral testicular neoplasms in 21-year-old identical twin men. The father had been exposed to atomic radiation in the South Pacific nine months before the conception of the twins. The measured badge radiation was within "tolerance limits." This is the seventh reported case of testicular neoplasms in twins and the fifth set of monozygotic twins.<sup>1</sup> <h3>Report of Cases</h3><h3>Case 1.—</h3> A 21-year-old mentally retarded (IQ, 74) male twin was admitted to Kaiser Foundation Hospital, Los Angeles, in October 1974 because of an enlarged left testicle found during routine physical