tbuckley/cabot-search huggingface dataset:
The<i>I</i>allele of the<i>ACE</i>gene is associated with improved exercise capacity in women with McArdle disease
Authors: F Gómez-Gallego, C Santiago, M Morán, M Pérez, J L Maté-Muñoz, M Fernández del Valle, J C Rubio, I Garcia-Consuegra, C Foster, I A L Andreu, M A Martín, J Arenas, A Lucia
Journal: British Journal of Sports Medicine (2007)

Background: McArdle disease is an uncommon metabolic disorder usually characterized by marked exercise intolerance although great individual variability exists in its phenotypic manifestation. Objective: The purpose of this study was to determine the association between angiotensin-converting enzyme ( ACE ) genotypes and indices of exercise capacity (peak oxygen uptake (V O 2 peak ), ventilatory threshold (VT) and gross mechanical efficiency (GE)) in patients with McArdle disease. Based on previous research, it was hypothesized that the I allele might favourably influence exercise capacity. Methods: Forty-four Spanish patients (23 males, 21 females) and 44 age-matched and gender-matched controls (23 males, 21 females) performed a graded cycle-ergometer test until exhaustion (for V O 2 peak and VT determination) and a 12 min constant-load test at the power output eliciting the VT (for GE determination). Results: No significant difference (p&gt;0.05) was found in indices of exercise capacity between ID + II genotypes and DD homozygotes in the group of male patients, male controls and female controls. However, in the group of female patients, the ID + II group (n = 11) had a higher V O 2 peak than DD homozygotes (n = 10) (15.8 (SEM 1.6) ml/kg/min versus 11.9 (SEM 0.9) ml/kg/min, respectively; p&lt;0.05). Conclusions: The I allele of the ACE gene is associated with a higher functional capacity in female patients, and might partly explain the individual variability in the phenotypic manifestation of McArdle disease.
CATCHY NAMES AND THEIR DANGERS.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE "BURST ABDOMEN"
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Case 21-2012: A 27-Year-Old Man with Fatigue, Weakness, Weight Loss, and Decreased Libido
Authors: Brian Elbel, Jonathan Cantor, M Mijanovich
Journal: New England Journal of Medicine (2012)

notices would calories from sugar-sweetened beverages purchased increase.When we considered only purchases of sugar-sweetened beverages subject to the policy, the mean calories from the beverages was 230±86 kcal per consumer.The difference in calories if 100% of these consumers switched to 16 oz would be -74 kcal (95% CI, -78 to -71) per consumer.We provide data on a number of possible consumer responses to the policy on sugar-sweetened beverages at fast-food restaurants.In most but not all of our simulations, the policy appears to be associated with a decrease in calories from sugar-sweetened beverages purchased at fast-food restaurants.
Disciplining midwives.
Authors: J. O. Drife
Journal: BMJ (1988)

<h3>Abstract</h3> <h3>Background</h3> The COVID-19 pandemic has resurfaced in India in the form of a hard-hitting second wave. This study aims to compare the clinical profile of the first wave (April-June 2020) and the second wave (March-May 2021) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in a single tertiary care center of India. This will help prioritize the target population group and management strategies in the upcoming third wave if any. <h3>Methods</h3> In this retrospective observational study, we examined the demographic profile, symptoms at presentation, the severity of illness, baseline investigations, treatments received, underlying comorbidities, and outcomes of the COVID-19 patients belonging to the first (W1) and the second wave (W2) of the pandemic in India. <h3>Findings</h3> Among 106 patients in W1 and 104 patients in W2, the age group affected most was 37·1 (SD=16·9) years compared with 50.5 (SD=17.7) years respectively. The baseline oxygen saturation is lower in W2, being 84·0 (13·4) % compared with 91·9 (7·4) % in W1. 70.2 % of the cases belonged to the severe category in W2 compared to 37.5% in W1. W2 patients demonstrated higher transaminase levels [SGOT, 108.3 (99.3) v/s 54.6 (69.3); SGPT, 97.6 (82.3) v/s 58.7 (69.7)] with respect to W1. Similarly, the CT severity score for W2 [29.5 (6.7)] was higher than W1 [23·2 (11·5)][All P&lt;0.05]. The proportion of patients requiring oxygen (81.8% v/s 11.2%), high flow nasal cannula (11.4% v/s 5.6%), non-invasive ventilation (41.2% v/s 1.5%), invasive ventilation (24.5% v/s 0.9%), as well as ICU/HDU admissions (56.4% v/s 12.0%) was higher for W2 as compared with W1. The measured case fatality rate varies from 29% for W2 to 9.6% for W1. <h3>Interpretation</h3> Higher age, oxygen requirement, ventilator requirement, ICU admission, and organ impairment are more prevalent in the admitted COVID-19 cases during the second wave that has hit India compared to the first wave and associated with more fatalities. Strategy for another wave should be planned accordingly. <h3>Key points</h3> <h3>Question</h3> What are the differences between the clinical profile of the first wave (W1) and the second wave (W2) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in a single tertiary care center of India? <h3>Findings</h3> In this observational study among 106 patients in W1 (April-June 2020) and 104 patients in W2 (March-May 2021), there were higher proportion of increased age, oxygen requirement, ventilator requirement, ICU admission, and organ impairment in the admitted COVID-19 cases during the second wave. <h3>Meaning</h3> The second wave hits India badly than the first wave and associated with more fatalities.
Successful treatment of systemic Chromobacterium violaceum infection
Authors: B. Victorica
Journal: JAMA (1974)

Sepsis followed a breast abscess in an otherwise healthy young adult. Cultures of the abscess yielded pure growth of<i>Chromobacterium violaceum</i>. Initiation of specific antibiotic therapy shortly after the onset of sepsis resulted in recovery. (<i>JAMA</i>230:578-580, 1974)
ABSORPTION AND EXCRETION OF SILICA
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Killing Heat
Authors: Arthur L. Kellermann, Knox H. Todd
Journal: New England Journal of Medicine (1996)

Heatstroke is common and often deadly. The pathophysiology of the syndrome is understood, and effective treatment has been well defined.13 Clinicians know that patients' chances of survival depend on prompt diagnosis and rapid cooling. Otherwise, a cascade of events will lead to irreversible injury or death.Heatstroke is preventable. We know the epidemiologic features of the disorder, and effective steps to prevent heatstroke have been clearly defined.410 To avoid heat-related deaths, a community must recognize the impending problem promptly. Once a heat-related emergency is identified, effective measures must be implemented at once. Otherwise, many deaths will follow.In . . .
229P A single arm, multicenter, phase II trial of oxaliplatin plus capecitabine in the perioperative treatment of locally advanced gastric adenocarcinoma in combination with D2 gastrectomy (NEO-CLASSIC)
Authors: L. Tianshu, Y. Sun, Y. Min, H. Cao, L. Yingbin, Y. Wang
Journal: Annals of Oncology (2016)
Let's Provide Primary Care to All Uninsured Americans—Now-Reply
Authors: Gordon T. Moore
Journal: JAMA (1991)

<h3>In Reply.</h3> —The foregoing letters cite a number of concerns about my proposal to provide primary care to uninsured Americans. The issues raised are typical of the intensely felt objections raised to any of the proposals for universal health care coverage—issues such as physician payment, malpractice, rationing, manpower incentives, and more. My proposal does not purport to solve these problems but rather to put a temporary "fix" in place—a simple, cost-effective safety net for uninsured Americans—while we continue the debate. Primary care, paid for in the fashion I described, could provide basic services where none now exist, and the plan would pay physicians something for services for which they now receive nothing. Surely this is preferable, as a temporary step, to continuing the current embarrassment of being the richest country in the world, yet failing to provide the most basic of health services to so many of our citizens.
Reply
Authors: N. Wilson, M. Silverman
Journal: Thorax (1986)

Gaso-oesophageal reflux and childhood astusa: the acid test SIR-We would like to comment on the paper by Dr N Wilson and colleagues (August 1985;40:592-7) concerning the relationship between gastro-oesophageal reflux and childhood asthma.The authors have demonstrated that some asthmatic children have increased bronchial responsiveness after swallowing acid solutions, detectable by a change in histamine PC20 (the concentration of histamine producing a 20% fall from baseline peak expiratory flow), but not by changes in peak expiratory flow measurements.The relationship between this phenomenon and oesophageal reflux, as measured by sleeping oesophageal pH monitoring, is less convincing.
Sports Medicine
Authors: Letha Y. Hunter
Journal: JAMA (1985)

This multiauthored text edited by Dr Strauss is a comprehensive presentation on nontraumatic medical problems in sports and exercise. It is primarily intended for physicians but could also be useful to physical therapists, trainers, and exercise physiologists. Although containing much technical material, the text is written in a style that would not overwhelm nonphysicians with an adequate background in human anatomy and physiology. The book is organized into five sections. The first two deal with general medical concerns of the athlete, with chapters organized according to organ systems. Emphasis is given to the cardiovascular system. Chapters in the third section represent medical concerns of special sports participants—women, children, persons with chronic medical problems, the physically disabled, and the elderly. The fourth section lists environmental concerns in sports—heat, cold, altitude, and depth. The last section deals with selected topics of nutrition, drugs, travel, and sports psychology. The knowledgeable chapter authors write
Radiation-Induced, Chromosome Aberrations in Man
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
LECTURES ON TUBERCULOSIS OF THE KIDNEY.
Authors: CHARLES GREENE CUMSTON
Journal: JAMA (1898)

<h3>LECTURE I.</h3> Tuberculosis of the kidney occurs in two forms, viz., miliary granulations and tuberculous infiltration of the kidney. The first form is a medical tuberculosis, while the second is more or less surgical. Durand-Fardel has described a special form of renal tuberculosis. He saw a case in which he found great quantities of bacilli but which had not produced any pathologic change in the kidney; the glomeruli contained Koch's bacillus in their capillary loops, but the organism had not had sufficient time to produce irritative lesions, for all the renal tissue was found normal, even the structure of the glomeruli was healthy. Some vessels which were packed with bacilli to such an extent that under a lower power their cavity appeared like a red speck, were also normal and no trace of cell proliferation could be detected around them. Daunic has reported a similar case. Death occurred with great
Internal sphincterotomy.
Authors: A. P. Clery, M. Feely
Journal: BMJ (1970)

MEBDITHALLike most of us, the young doctor is faced with the painful necessity of having to earn a living, particularly as he is likely to be married and often has a family to support.After, say, two years' work, he can enter general practice, an interesting and rewarding life with much variety, or decide on radiology as a career.In the former case he will have a fairly wide choice of district and start at £3,000-£4,000 p.a., achieving a high salary in the not too distant future.If he should choose radiology he will start as registrar for two years or more, obtain his D.M.R.D. and then become senior registrar for three years, altogether about five years' training.He can then take a further qualifica-
HAY FEVER.
Authors: W. H. WEAVER
Journal: JAMA (1898)

My chief purpose in reviewing the subject of hay fever is to define more clearly, if possible, the philosophy of its treatment by internal medication in addition to the recognized surgical measures which should be adopted. The majority of patients have received only local nasal treatments, which have given variable success, no effort being made at internal medication. My experience in the past three seasons has convinced me that one of the most important factors in the pathology of the disease is the uric acid diathesis, or rather a condition of temporary uricacidemia. Uric acid, with other toxic matters which are retained with it in the blood, is certainly a violent irritant to the tender and irritable tissues in hay fever as well as in other diseased states; and when its importance is fully recognized it will be much easier to relieve the sufferer. The nervous symptoms are reflex, from
Regarding Propagation.
Authors: A. C. McClanahan
Journal: JAMA (1901)

Chicago, Oct. 8, 1901. <h3>To the Editor:</h3> —In the discussion of Dr. George J. Englemann's interesting paper on the "Increasing Sterility of American Women," reported inThe Journalfor October 5, there are exhibited a depth of concern and a degree of alarm that do not seem to be warranted by those disclosures in the Doctor's paper which furnished the material for the greater part of the discussion. The chief facts shown in the paper are, that sterility has increased rapidly during the last century; that the present average percentage of childless marriages in this country is about twenty; that the average number of children per married couple is 1.8, and that the chief causes of this increasing sterility and diminishing fecundity are the intentional prevention of conception and interruption of gestation. These are intensely interesting facts, and the labor which their accumulation must have cost the author, entitles him
Hepatitis B Vaccination Coverage Among Adults—United States, 2004
Journal: JAMA (2006)

Hepatitis B virus (HBV) infection is a major cause of cirrhosis and liver cancer in the United States. The Advisory Committee on Immunization Practices (ACIP) has recommended a comprehensive strategy to eliminate HBV transmission, including prevention of perinatal HBV transmission; universal vaccination of infants; catch-up vaccination of unvaccinated children and adolescents; and vaccination of unvaccinated adults at increased risk for infection. The incidence of acute hepatitis B has declined 75%, from 8.5 per 100,000 population in 1990 to 2.1 per 100,000 population in 2004, with the greatest declines (94%) among children and adolescents. Incidence remains highest among adults, who accounted for approximately 95% of the estimated 60,000 new infections in 2004. To measure hepatitis B vaccination coverage among adults, data were analyzed from the 2004 National Health Interview Survey (NHIS). This report summarizes the results of that analysis, which indicated that, during 2004, 34.6% of adults aged 18-49 years reported receiving hepatitis B vaccine, including 45.4% of adults at high risk for HBV infection. To accelerate elimination of HBV transmission in the United States, public health programs and clinical care providers should implement strategies to ensure that adults at high risk are offered hepatitis B vaccine.
Keeping Dry
Authors: Jack Coulehan
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE EFFECT OF TOBACCO IN HEALTH AND DISEASE.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Failure of a tapering dose of oral methylprednisolone to treat reactions to poison ivy
Authors: T. J. Ives
Journal: JAMA (1991)

<h3>To the Editor.</h3> —During the poison ivy season, the use of an oral corticosteroidtapering regimen is prescribed routinely for cases unresponsive to topical preparations. One of the most commonly prescribed corticosteroid products, Medrol Dosepak (Upjohn Co, Kalamazoo, Mich), is a 6-day tapering course of oral methylprednisolone. Anecdotal reports abound about flare-ups of severe cases of<i>Rhus</i>dermatitis within several days after completion of this product, but no documentation of this reaction exists, either in the medical literature or from the manufacturer. We have found that a tapering dose of prednisone over 12 days has not been associated with another flare-up of symptoms in severe cases of<i>Rhus</i>dermatitis. We report the use of this regimen in a case that is representative of this patient population. <h3>Report of a Case.</h3> —A 32-year-old woman presented with a complaint of recurrent poison ivy for the past 5 days. While backpacking 2 weeks previously,