tbuckley/cabot-search huggingface dataset:
Experimental irritant contact dermatitis due to cumulative epicutaneous exposure to sodium lauryl sulphate and toluene: single and concurrent application
Authors: W. Wigger-Alberti, A. Krebs, P. Elsner
Journal: British Journal of Dermatology (2000)

In clinical practice, cutaneous exposure to a variety of irritants such as surfactants and solvents is frequent. Although the induction of irritant dermatitis by single irritants has been extensively studied in recent years, our knowledge of the effects of simultaneous application of different irritants is limited. Using non‐invasive techniques for measurements of transepidermal water loss (TEWL) and skin colour reflectance, we quantified the irritant effects of single and concurrent application of 0·5% sodium lauryl sulphate (SLS) and undiluted toluene (TOL) in vivo. The irritants were applied twice daily for 30 min to the volar forearms of 20 volunteers. Repeated application of SLS and TOL induced an irritant reaction, as indicated by an increase in TEWL and skin redness. In contrast to SLS alone, the application of TOL alone induced only a moderate increase in TEWL, confirming previous results. Concurrent application of SLS/TOL and TOL/SLS induced significantly stronger reactions than those caused by twice daily application of each irritant on its own. Our results demonstrate that a mixed application of an anionic detergent and an organic solvent has an additive effect on skin irritation. It is suggested that pretreatment with SLS causes an increased susceptibility to TOL irritation and vice versa. Thus, the necessity for special precautions against skin absorption of TOL when handling detergents such as SLS is emphasized.
URTICARIA FACTITIA*
Authors: P. B. MUMFORD
Journal: British Journal of Dermatology (1926)

Journal Article URTICARIA FACTITIA Get access P. B. MUMFORD, M.D., M.R.C.P. P. B. MUMFORD, M.D., M.R.C.P. Assistant Medical Officer, Manchester and Salford Skin Hospital; Assistant to the Dermatologist, Manchester Royal Infirmary Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 38, Issue 11, 1 November 1926, Pages 444–447, https://doi.org/10.1111/j.1365-2133.1926.tb09243.x Published: 01 November 1926
Index Catalogue of the Library of the Surgeon-General's Office, United States Army. Authors and Subjects. Vol. IV.
Journal: JAMA (1883)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Misspelled Investigator Name in: Extracranial-Intracranial Bypass Surgery for Stroke Prevention in Hemodynamic Cerebral Ischemia: the Carotid Occlusion Surgery Study Randomized Trial
Authors: Alejandro Jadad, Matthew To, Mohamed Emara, Jennifer Jones
Journal: JAMA (2011)

William J. Powers, MD; William R. Clarke, PhD; Robert L. Grubb, MD; Tom O. Videen, PhD; Harold P. Adams, MD; Colin P. Derdeyn, MD; for the COSS Investigators
Lectures on the Pathology, Diagnosis, and Treatment of Bright's Disease
Authors: G. Johnson
Journal: BMJ (1873)

urine into the submucous tissues.Bear in mind that the changes LECTURES within the substance of the kidney are due to the retention and accumulation of the newly secreted acid urine within the tubes, and not to ON THE the regaurgitation of foetid ammoniacal urine, as has recently been sug- PATHOLOGY, DIAGNOSIS, AND-TREAT- gested.Without doubt, the urine in the bladder in cases of old stric- BRIGHT'S DISEASE.~~~ture, vesical calculus, and cystitis, is often foeLid from decomposition ; MENT OF BRG TS D EA .but the regurgitation of such urine into the uriniferous tubes is a phy-By GEORGE JOIINSN, M.D., F.R.S.,sical impossibility.If you have ever attempted to inject the tubes
Interatrial Communication and Left Atrial Hypertension: Cause of Continuous Murmur
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
IODOPHILIA.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Familial Hyperparathyroidism
Authors: Alan L. Graber
Journal: JAMA (1968)

Hyperparathyroidism occurred in four members of a family, involving two generations. The tendency for involvement of multiple parathyroid glands and for recurrence was prominent, illustrating the necessity for a thorough surgical exploration and a long follow-up. Awareness of the familial syndrome resulted in early treatment of three of the four affected members, possibly avoiding the damaging renal effects of prolonged hypercalcemia.
Be Careful With Statistics—They're Fragile
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Errata
Authors: J Baek, H Kang, S Na, J Lee, J Roh, J Lee, H Kim, S Park
Journal: British Journal of Dermatology (2012)

British Journal of DermatologyVolume 167, Issue 2 p. 461-461 Free Access Errata This article corrects the following: Intensified photodynamic therapy of actinic keratoses with fractional CO2 laser: a randomized clinical trial K. Togsverd-Bo, C.S. Haak, D. Thaysen-Petersen, H.C. Wulf, R.R. Anderson, M. Hædesdal, Volume 166Issue 6British Journal of Dermatology pages: 1262-1269 First Published online: May 25, 2012 First published: 26 July 2012 https://doi.org/10.1111/j.1365-2133.2012.11136.xCitations: 1AboutSectionsPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat In the article by Togsverd-Bo et al.1 an author’s name was listed incorrectly. The author listed as M. Hædesdal should have been listed as M. Hædersdal. We apologise for this error. Reference 1 Togsverd-Bo K, Haak CS, Thaysen-Petersen D et al. Intensified photodynamic therapy of actinic keratoses with fractional CO2 laser: a randomized clinical trial. Br J Dermatol 2012; 166: 1262– 9. Wiley Online LibraryCASPubMedWeb of Science®Google Scholar Citing Literature Volume167, Issue2August 2012Pages 461-461 ReferencesRelatedInformation
Biological Effects of Short-Term, High-Concentration Exposure to Methyl Isocyanate. I. Study Objectives and Inhalation Exposure Design
Authors: Darol E. Dodd, Fred R. Frank, Edward H. Fowler, Catherine M. Troup, Robert M. Milton
Journal: Environmental Health Perspectives (1987)

Early reports from India indicated that humans were dying within minutes to a few hours from exposure to methyl isocyanate (MIC). Attempts to explain the cause(s) of these rapid mortalities is where Union Carbide Corporation concentrated its post-Bhopal toxicologic investigations. The MIC studies involving rats and guinea pigs focused primarily on the consequences of acute pulmonary damage. All MIC inhalation exposures were acute, of short duration (mainly 15 min), and high in concentration (ranging from 25-3506 ppm). MIC vapors were statically generated in a double chamber exposure design. Precautionary measures taken during exposures are discussed. Guinea pigs were more susceptible than rats to MIC exposure-related early mortality. A greater than one order of magnitude difference was observed between an MIC concentration that caused no early mortality in rats (3506 ppm) and an MIC concentration that caused partial (6%) early mortality in guinea pigs (225 ppm) for exposures of 10 to 15 min duration. For both species, the most noteworthy clinical signs during exposure were lacrimation, blepharospasm, and mouth breathing. Fifteen minute LC50 tests with 14-day postexposure follow-up were conducted, and the LC50 (95% confidence limit) values were 171 (114-256) ppm for rats and 112 (61-204) ppm for guinea pigs. Target exposure concentrations for the toxicologic investigations of MIC-induced early mortality were established. A short summary of pertinent results of Union Carbide Corporation's post-Bhopal toxicologic investigations is presented.
WASHINGTON NEWS
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An operation for the correction of truncus arteriosus
Authors: D. C. McGoon
Journal: JAMA (1968)

An operation achieved success in correcting the truncus arteriosus anomaly. The pulmonary arteries were disconnected from the truncus, and, by the manner in which the ventricular septal defect was closed, it became the true aorta. A new outflow from the right ventricle to the pulmonary arteries was established by the use of a homograft of ascending aorta including the aortic valve. This use of a homograft may be the factor that allowed success in the operation as opposed to previous attempts at similar operations with synthetic materials. The corrective operation will probably prove to be the method of choice for the treatment of patients with truncus arteriosus.
Dividends from Universal Application of Simple Cancer Case-Finding Procedures to Well Persons
Journal: CA A Cancer Journal for Clinicians (1953)

roentgeno grams of the chest for all men more than 50 years of age will reveal more lung cancers at a time when resection can be performed and cure ex pected. Routine use of vaginal smear in all women, plusSITE more frequent use of bi opsy, will disclose more early uterine cancer PRESENT CURES CASE FINDING METHOD CURES POSSIBLE
JAMA Psychiatry
Authors: Phil Fontanarosa, Annette Flanagin, Brenda Gregoline, Tracy Frey, Iris Lo, Kevin Brown, Amanda Ehrhardt, M Newman, Suzanne Walker, Connie Manno Senior, Sara Billings, Timothy Gray, Juliet Orellana, Paul Ruich, Kirby Snell, Catherine Alden, Stephanie Beckmeyer, Jane Calayag, Jan Clavey, Mary Coerver-Connolly, Paula Glitman, Laura King, Regina Lilly, Charon Pierson, Rebecca Ritke, Thressa Smith, Divya Sreekumar, Donna Thordsen, Christine Tilles, Carolina Woods, Editorial Assistant, Wanda Hill, Larry Bryant, Jacob Kendall-Taylor, Monica Mungle, Fanny Brown, Anna Bukowski, Lee Calibeo, Lenette Gardner-Gullens, Tosca Hall, Erin Kato, Rachell Lozano, Caroline Sietmann, Angelia Scientifi, Michael Berkwits, Eric Butkus, Jesse Mcquarters, Elena Guobyte, Emily Ling, Daniel Morrow, Hasaballa Ally, Reuben Rios, Mary Ferkaluk, Karen Bucher, Andy Rekito, Nick Reback, Lohitha Kethu, David Song, Deputy Livingston, Thomas Cole, Marla Hall, Deanna Willis, Yolanda Davis, Joseph Thornton, Deanna Bellandi, Jim Periodical, Thomas Easley, Brian Shields, Karen Adams-Taylor, Paul Gee, Monica Smith, Jeff Ery, J Bonistalli, Kathy Russell, Mirna Monal, Stacey Mchugh, Marketing Thornbury, Tricia Castellano, Anna Manager, Thalia Moss, Sade Deramus-Townsend, Tony Ralenkotter, Marsha Fogler, Rachel Sisholtz, Saskia Bolore, Gretchen Linder, Brian Mccartney, Christine Hearne, Natasha Staff, Henry Aguillon, David Baum, Ron Thomas, Rick Bell, Elizabeth Solaro, Sara Zimmerman, Geoff Rey, Lindsay Dawson, Ellen Gibson, Craig Mccaff Rey, Michael Mcgraw, Daniel Pickhardt, Romando Rossini, Sarah Subramanian, Stacy Tucker, Walsh Business, Analyst Sirisha, Alluri Staff, Millette Jackson-Bates, Tom Miller, Morgan Osgood, Karl Elvin, Nancy Essex, Jaye Mize, Sean O'donnell, Sue Managers, David Antos, Anthony Bautista, Chris Borden, Debbie Camp, Jennifer Carney, Lydia Cruz, Scott Curl, Diane Darnell, Nanette Diaz, Jordynn Farrar, Allison Hughes, Colleen Kelly, John Lash, Chris Meyer, Annemarie Neff, J Neff, Sean Ohlson, Phil O'leary, Bill Pedone, Susan Price, Jaynam Shah, Erin Spencer, Denise Steinhauser, Joe Advertising, Production Services, Ahmed Avendano, Kim Boler, Rhonda Brown, Fin Carter, Michael Deegan, Daniel Degroot, Euwanaha Joiner-Smith, Joshua Lane, Cindy Rendlen, Ellen Yoshihara, Circulation Services, Julie Burton, Ronna Hewitt, Mary Sieck, Geneine Someren, Jamaal Vargas, Content Systems, Mike Bujewski, Nathan Mitre, Digital Production, Regina Brownlee, Amanda Camino, Brenda Chandler- Grayer, Emily Dunn, Amy Evers, Maleeka Holden, Teri Hutchison, Dan Knowles, Joshua Lampinen, Natalie Marsh, Patricia Panek, Marla Seidell, La Son, Diggs Sledge, Julian Graphics, Joe Amft, James Collver, Maria Duda, Fred Furtner, Carolyn Hall, Maria Kowalkowski, Proofreading Carol, Joy Farrell, Maria Giannini, Sasha Grossman, Judith Literskis, Teresa Omiotek, Michael Ryder, Sara Dibari, Martin Paulus, Helen Simpson, New York, John Torous, Helena Chmura Kraemer, Palo Alto, California David, Rosenfi Eld, Guido Schwarzer, Linda Valeri, Tyler Vanderweele, Jama Network, Howard Bauchner
Journal: JAMA Psychiatry (2019)
The Psychology of Modernism in Literature
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
"Fragile" X chromosome: major link to mental retardation
Authors: G. McBride
Journal: JAMA (1981)

Evidence continues to mount that from one third to one half of all X-chromosome-linked mental retardation in kindreds is associated with the so-called fragile X chromosome (<i>JAMA</i>[MEDICAL NEWS] 1979; 242:1829-1830). This makes the defect "the second most common clearly defined cause of mental retardation after Down's syndrome," says Park S. Gerald, MD, professor of pediatrics at Harvard Medical School, Boston, and chief of the division of clinical genetics at Boston's Children's Hospital Medical Center. Gerald also believes that because of the implications for genetic counseling, there should be no failure to do the cytogenetic search for the defect in suspicious cases. However, there are isolated reports that the fragile X chromosome has been found in a few males who are not mentally retarded. In several ways, the story raises almost more questions than it answers. A fragile X chromosome is essentially normal in appearance except that one or both
SCHOOL FOR HEALTH OFFICERS.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 4301: Chimeric Mice Lacking Microsomal Prostaglandin E <sub>2</sub> Synthase-1 (mPGES) In Bone Marrow Develop Adverse Left Ventricular Remodelling After Myocardial Infarction
Authors: Barry Rubin, Philip Konecny, Armand Keating, Shafie Fazel, Xing-Hua Wang, Denis Angoulvant, Eva Stefanski, Ren-Ke Li, Thomas Lindsay, Per-Johan Jakobsson, Norbert Degousee
Journal: Circulation (2008)

Introduction. mPGES functions downstream from COX-2 in the inducible PGE 2 biosynthetic pathway, and can be expressed by cardiac myocytes and inflammatory cells. mPGES gene targeted mice (mPGES −/− ) develop LV dilation and impaired contractile function after MI. The purpose of this study was to determine if mPGES in bone marrow (BM) derived inflammatory cells regulates LV remodelling after MI. Methods. Six week old female mPGES +/+ mice were irradiated with 9.5 Gy and transplanted with BM from male mPGES +/+ or mPGES −/− mice (BM +/+ or BM −/− chimeras, respectively). After 10 weeks, the left coronary artery was ligated. Echocardiography was used to assess LV dimensions and function in vivo . After fixation in situ , LV dimensions and infarct volume was assessed by planimetry. The efficiency of BM transplantation, determined by the ratio of syr to gapdh DNA, measured by real time PCR, was 98%. Results. There was no difference in LV dimensions or function between BM +/+ and BM −/− mice before MI (not shown). Between 7 and 28 days post MI, ejection fraction did not change in BM +/+ mice, but decreased significantly in BM −/− mice (Table ). BM −/− mice also had a higher LV diameter (2.7 ± 0.1 vs. 3.1 ± 0.1 mm, p = 0.0001) and LV volume (14 ± 0.8 vs. 18 ± 1.0 mm 3 , p = 0.025) than BM +/+ mice 28 days after MI. In contrast, there was no difference in the percentage of infarcted LV, heart rate or cardiac output between BM +/+ and BM −/− mice after MI. Survival of BM +/+ vs. BM −/− 28 days after MI was similar (75% vs. 72%, log rank, p = 0.86). Conclusion. mPGES1 in bone marrow cells that localize to the heart after MI is necessary to maintain post infarction LV contractile function, and to prevent adverse LV remodelling. Use of mPGES inhibitors as substitutes for COX-2 inhibitors may be detrimental in patients with coronary artery disease.