tbuckley/cabot-search huggingface dataset:
Delayed Drug Hypersensitivity Reactions
Authors: Werner J. Pichler
Journal: Annals of Internal Medicine (2004)

Letters4 May 2004Delayed Drug Hypersensitivity ReactionsWerner J. Pichler, MDWerner J. Pichler, MDFrom University of Bern, CH-3010 Bern, Switzerland.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-140-9-200405040-00028-w2 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Drug dosage is important in generating an immune response, but there are no data available that would suggest that a high dosage may cause, for example, bullous skin diseases while a small dose causes urticaria. It seems that an individual's predisposition and the type of drug are more important to the type of reaction than the drug dosage. In already sensitized persons, drug dose is also important for eliciting symptoms. However, small doses can often cause symptoms, which obscures the role of dosage.It is controversial, and probably depends on the drug, whether continued treatment and thus higher ...Reference1. Knowles SR, Shapiro LE, Shear NH. Anticonvulsant hypersensitivity syndrome: incidence, prevention and management. Drug Saf. 1999;21:489-501. [PMID: 10612272] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From University of Bern, CH-3010 Bern, Switzerland. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoDelayed Drug Hypersensitivity Reactions Werner J. Pichler Delayed Drug Hypersensitivity Reactions Mark H. Hyman Metrics 4 May 2004Volume 140, Issue 9Page: W-36KeywordsAllopurinolAnticonvulsantsDrugsEosinophiliaHypersensitivityImmune responseSkin diseasesUrticaria ePublished: 4 May 2004 Issue Published: 4 May 2004 Copyright & PermissionsCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Selected Abstracts
Journal: JAMA (1978)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE ABSORPTION OF LEAD THROUGH THE SKIN
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Keratinocyte Carcinoma
Authors: M. R. Albert, M. A. Weinstock
Journal: CA A Cancer Journal for Clinicians (2003)

Keratinocyte carcinoma is by far the most common cancer in the United States. Basal cell carcinomas and squamous cell carcinomas account for approximately 80% and 20% of cases of KC, respectively. The term nonmelanoma skin cancer is commonly used to refer to squamous cell carcinomas and basal cell carcinomas; however, other types of nonmelanoma skin cancer, such as adnexal tumors and sarcomas, are less common and differ in their cell type, behavior, and epidemiologic features from KC.1 Primary care clinicians are well positioned to diagnose KC and to educate patients about preventive measures such as sun protection and self-examination. Here we review epidemiologic data and strategies for prevention, diagnosis, and clinical management of KC.
IRS2 takes center stage in the development of type 2 diabetes
Authors: M. J. Brady
Journal: Journal of Clinical Investigation (2004)

The etiology of type 2 diabetes is characterized by obesity, insulin and leptin resistance, and compensatory β cell hyperplasia followed by islet degeneration, resulting in the eventual dysregulation of glucose and lipid homeostasis. The recent identification of insulin receptor substrate 2 (IRS2) as a central player in the pathophysiology of many of these processes suggests a potentially unifying molecular link underlying the initiation and progression of type 2 diabetes.
ACS-NIH organ transplant registry. Second scientific report
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Renaissance of Prostatectomy
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medico-Chirurgical Transactions.
Journal: JAMA (1884)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Computer-assisted medical decision-making: interest growing
Authors: T. Ziporyn
Journal: JAMA (1982)

"C omputers can never replace physicians. Only physicians have the ability to reason logically and to mix that reason with intuition, experience, and ethics—something no machine can ever learn to do." Or so many physicians have been telling people proposing computer-assisted medical decision making (CMD) since the early 1960s, and controversy has continued. But now it looks like the two sides are nearing agreement: Computers may never replace physicians, but they can and will assist their decisions. "Assist" is the key word in CMD. Early advocates tended to overestimate the powers of the computer and promised complete clinical evaluation at the push of a button. It was natural for physicians to feel somewhat threatened. It was also natural that, with experience, such promises had to be modified. Today there still are only several functioning knowledge-based decision systems—called "knowledge-based" because they make inferences using a data base of medical information stored
Protocole séquentiel de multistenting dans la sténose biliaire après transplantation hépatique: une analyse prospective
Journal: Endoscopy (2019)

Le taux de complications biliaires chez les receveurs de transplantation dans les séries publiées varie de 8 % à 35 %. Le traitement endoscopique standard de la sténose anastomotique consiste en une sphinctérotomie et une dilatation pneumatique progressive avec pose multiple de stent. Une étude récente a montré, pour la première fois dans une population de transplantation, les résultats dʼun protocole séquentiel de pose dʼendoprothèses multiples, dans lequel une endoprothèse supplémentaire était placée lors des CPRE successives sans retrait des stents préalablement posés, avec le même taux de résolution de sténose et le même taux dʼévénements indésirables, mais lʼapproche séquentielle était plus courte et plus rentable.
Error in Table 1
Authors: Pia Nørrisgaard, Klaus Bønnelykke, Hans Bisgaard
Journal: JAMA Pediatrics (2020)

Donna M. Vallone, PhD, MPH; Alison F. Cuccia, MSPH; Jodie Briggs, MPP, MA; Haijun Xiao, MS; Barbara A. Schillo, PhD; Elizabeth C. Hair, PhD
Reply to E. David Crawford and Bo-Eric Persson's Letter to the Editor re: Giorgio Gandaglia, Maxine Sun, Jim C. Hu, et al. Gonadotropin-releasing Hormone Agonists and Acute Kidney Injury in Patients with Prostate Cancer. Eur Urol. In press. http://dx.doi.org/10.1016/j.eururo.2014.01.026
Authors: Giorgio Gandaglia, Maxine Sun, Alberto Briganti, Pierre I. Karakiewicz
Journal: European Urology (2014)
Oxygenator May Reduce Blood Trauma
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Predicting the response to nonpharmacologic treatment in mild hypertension
Authors: T. G. Pickering
Journal: JAMA (1992)

The physician whose patient presents with blood pressure in the gray zone between normotension and hypertension faces two problems. Should treatment be prescribed, and what can be done to prevent the pressure from rising any higher? Drug treatment, while undoubtedly effective, is expensive, frequently accompanied by side effects, and minimally cost-effective for such patients. Nonpharmacologic treatment offers a potential approach, but here again there are problems. A bewildering array of treatment modalities have been proposed, ranging from dietary modification to behavioral changes, the efficacy of which is in many cases poorly substantiated. Furthermore, it is becoming increasingly clear that individual patients differ widely in the degree to which their blood pressure responds to any type of treatment, See also pp 1213 and 1221. whether pharmacologic or nonpharmacologic. Altering treatment is of no great consequence when it simply means writing a new prescription for a different medication, but many of the
Dermatitis Medicamentosa
Authors: C. F. H. Vickers
Journal: BMJ (1961)

PEAK EXPIRATORY FLOW BrrJ which did not persist for as much as three months in the year.Sitting height was not found to be significantly related with P.E.F. when allowance was made for age.The College of General Practitioners (1961) also found a similar rate of decline of mean P.E.F. with age in non-bronchitic subjects, and their values were uniformly lower than those found among " normal" men as defined in this study.The College of General Practitioners gave figures for non-bronchitic women indicating a rate of decline of P.E.F. with age about half that experienced by the men.Higgins (1960, personal communication) found that the decline of P.E.F. with age in symptom-free men in the population he studied was similar to that found in our sample, and parallel to the decline in P.E.F. in symptom-free women.His values for P.E.F. in symptom-free men were a little higher than those given here.The values for P.E.F. in symptom-free women were approximately 200 I./min.lower than values for symptom-free men in the same age-group.
Lung Scintiscanning
Authors: E. James Potchen
Journal: JAMA (1968)

The incidence at autopsy of undiagnosed pulmonary emboli amply demonstrates the inadequacy of current diagnostic measures. Physicians alert to this discrepancy have renewed interest in the clinical assessment of regional pulmonary perfusion. The addition of radionuclides to the diagnostic armamentarium affords a supplementary means for the external detection of regional pulmonary function. We now measure regional pulmonary blood flow by two radioisotopic methods. In one, an inert radioactive gas is injected intravenously, and the regional lung perfusion is evaluated with multiple probes or a gamma camera. The isotope rapidly leaves the pulmonary capillaries and diffuses into the alveolar air. Rectilinear scintiscanning is not used, since rapid simultaneous measurements are necessary to distinguish perfusion from alveolar gas exchange. West<sup>1</sup>has recently reviewed these pulmonary-function studies with radioactive gases, and though I acknowledge the significance of ventilatory lung scans as an adjunct to macrocolloid perfusion scanning, space will not permit an
Intractable facial pain relieved by percutaneous trigeminal tractotomy
Authors: J. L. Fox
Journal: JAMA (1971)

Percutaneous trigeminal tractotomy was carried out in 12 patients suffering from intractable facial pain of benign and malignant etiologies. The technique requires placement of an electrode under local anesthesia into the ipsilateral descending trigeminal tract by percutaneous insertion of the guide-needle through the foramen magnum. Following coagulation of this pathway in the brainstem, facial analgesia was effected in every patient. In seven patients with head and neck neoplasms, pain relief occurred. In some of the benign pain problems, such as postherpetic neuralgia, pain relief was only transient in spite of effective analgesia.
Socioeconomic Predictors of High Allergen Levels in Homes in the Greater Boston Area
Authors: Barrett T. Kitch, Ginger Chew, Harriet A. Burge, Michael L. Muilenberg, Scott T. Weiss, Thomas A. E. Platts-Mills, George O'Connor, Diane R. Gold
Journal: Environmental Health Perspectives (2000)

In the United States, childhood asthma morbidity and prevalence rates are the highest in less affluent urban minority communities. More than 80% of childhood asthmatics are allergic to one or more inhalant allergens. We evaluated whether socioeconomic status was associated with a differential in the levels and types of indoor home allergens. Dust samples for an ELISA allergen assay were collected from the homes of 499 families as part of a metropolitan Boston, Massachusetts, longitudinal birth cohort study of home allergens and asthma in children with a parental history of asthma or allergy. The proportion of homes with maximum home allergen levels in the highest category was 42% for dust mite allergen (> or = 10 microg/g Der p 1 or Der f 1), 13% for cockroach allergen (> or = 2 U/g Bla g 1 or Bla g 2), 26% for cat allergen (> or = 8 microg/g Fel d 1), and 20% for dog allergen (> or = 10 microg/g Can f 1). Homes in the high-poverty area (> 20% of the population below the poverty level) were more likely to have high cockroach allergen levels than homes in the low-poverty area [51 vs. 3%; OR, 33; 95% confidence interval (CI), 12-90], but less likely to have high levels of dust mite allergen (16 vs. 53%; OR, 0.2; CI, 0.1-0.4). Lower family income, less maternal education, and race/ethnicity (black or Hispanic vs. white) were also associated with a lower risk of high dust mite levels and a greater risk of high cockroach allergen levels. Within a single U.S. metropolitan area we found marked between-community differences in the types of allergens present in the home, but not necessarily in the overall burden of allergen exposure.
Anesthesiology
Authors: R. K. Stoelting
Journal: JAMA (1991)

Anesthesiology in 1990 benefited from the introduction of new drugs and the availability of new information to guide daily practice. Advances in pharmacology included the introduction or imminent development of drugs with therapeutic profiles likely to lead to the displacement of currently used drugs. For example, a nonopioid analgesic lacking ventilatory depressant effects is now available, and the long-sought goal to find a suitable replacement for nitrous oxide seems achievable. There is new information that adds to our understanding of drug-induced hepatotoxicity and the role, if any, of anesthetic drugs in the occurrence of intraoperative myocardial ischemia. Traditional concepts, such as prolonged fluid fasting before the induction of anesthesia for elective operations, are being reconsidered, while the practice of administering potent opioids before a painful surgical stimulus is supported by previously unappreciated aspects of neurophysiology. Ketorolac J.X.etorolac tromethamine, a nonopioid antiinflammatory drug with analgesic effects equivalent to morphine, was introduced
Estrogens and risk of breast cancer
Authors: H. M. Lemon
Journal: JAMA (1987)

<h3>In Reply.—</h3> I have received 27 letters of response from doctors and their spouses across the nation. Of those, 26 were written by kind, concerned people offering advice and sharing memories. The letter from Dr Weiss-Harrison is the single exception. I have to wonder at her suggestion that I "become friendly." Six months have passed since I wrote "Our New Home." I have made some good friends here during that time, and none of the people with whom I have become friendly share her attitude toward others who are reaching out for help. As for persistence in seeking employment, I'm sure my weekly appearance at Job Service, holding a preschooler by the hand and an infant strapped to my back, might have convinced even Dr Weiss-Harrison of my determination, as would the long hours spent at the typewriter, on the telephone, and poring over the want ads. Fortunately, these efforts
Measles Vaccination
Authors: Carl F. Needles
Journal: JAMA (1990)

<h3>To the Editor.—</h3> The study by Edmonson et al<sup>1</sup>describes in detail the advent of measles infection in vaccinees. However, their discussion omits two factors that may be contributory. Measles virus can be immunosuppressive, even in vaccine form. It is well known that prior immunity against the bacillus of tuberculosis can be temporarily lost; in addition, response to varicella virus vaccine is embarrassed if measles vaccine is given first.<sup>2,3</sup> Second, since the present cluster of outbreaks began around 1985, it is possible that the wild virus has mutated, thus causing a secondary vaccine failure. We seem to be more handicapped in trying to solve this dilemma because we have not developed vehicles for studying the response of cellular immunity to measles vaccination.
Owens Leads Effort To Promote Cancer Research
Authors: H. Mclntosh
Journal: JNCI Journal of the National Cancer Institute (1991)

Owens Leads Effort To Promote Cancer Research Get access Hugh Mclntosh Hugh Mclntosh Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 4, 20 February 1991, Pages 239–240, https://doi.org/10.1093/jnci/83.4.239 Published: 20 February 1991