tbuckley/cabot-search huggingface dataset:
The Pathology and Treatment of Suppurative Diseases of the Ear: Being an abstract of the Harveian Lectures delivered before the Harveian Society of London
Authors: G. P. Field
Journal: BMJ (1892)

<h3>Background</h3> Internationally, hospital survival is lower for patients admitted at weekends and at night. Data from the UK National Cardiac Arrest Audit (NCAA) indicate that crude hospital survival was worse after in-hospital cardiac arrest (IHCA) at night versus day, and at weekends versus weekdays, despite similar frequency of events. <h3>Objective</h3> To describe IHCA demographics during three day/time periods—weekday daytime (Monday to Friday, 08:00 to 19:59), weekend daytime (Saturday and Sunday, 08:00 to 19:59) and night-time (Monday to Sunday, 20:00 to 07:59)—and to compare the associated rates of return of spontaneous circulation (ROSC) for &gt;20 min (ROSC&gt;20 min) and survival to hospital discharge, adjusted for risk using previously developed NCAA risk models. To consider whether any observed difference could be attributed to differences in the case mix of patients resident in hospital and/or the administered care. <h3>Methods</h3> We performed a prospectively defined analysis of NCAA data from 27 700 patients aged ≥16 years receiving chest compressions and/or defibrillation and attended by a hospital-based resuscitation team in response to a resuscitation (2222) call in 146 UK acute hospitals. <h3>Results</h3> Risk-adjusted outcomes (OR (95% CI)) were worse (p&lt;0.001) for both weekend daytime (ROSC&gt;20 min 0.88 (0.81 to 0.95); hospital survival 0.72 (0.64 to 0.80)), and night-time (ROSC&gt;20 min 0.72 (0.68 to 0.76); hospital survival 0.58 (0.54 to 0.63)) compared with weekday daytime. The effects were stronger for non-shockable than shockable rhythms, but there was no significant interaction between day/time of arrest and age, or day/time of arrest and arrest location. While many daytime IHCAs involved procedures, restricting the analyses to IHCAs in medical admissions with an arrest location of ward produced results that are broadly in line with the primary analyses. <h3>Conclusions</h3> IHCAs attended by the hospital-based resuscitation team during nights and weekends have substantially worse outcomes than during weekday daytimes. Organisational or care differences at night and weekends, rather than patient case mix, appear to be responsible.
ARRHYTHMIAS AND THE "EFFICIENT HEART"
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Manuscripts Approved for JNCI, July 10 to August 10, 1963
Journal: JNCI Journal of the National Cancer Institute (1963)

Manuscripts Approved for JNCI, July 10 to August 10, 1963 Get access JNCI: Journal of the National Cancer Institute, Volume 31, Issue 3, September 1963, Pages 741–743, https://doi.org/10.1093/jnci/31.3.741-a Published: 01 September 1963
Prognostic impact of SOX9 in stage II colon cancer: Results from a large nationwide cohort.
Authors: Torben Hansen, Sanne Kjær-Frifeldt, Ann Christina Eriksen, Jan Lindebjerg, Lars Henrik Jensen, Anders Kristian Moeller Jakobsen, Flemming Brandt Sørensen
Journal: Journal of Clinical Oncology (2019)

e15165 Background: Up-regulation of the transcription factor SOX9 has been described in colon cancer, and it has been argued that differences in the expression levels dictates cell proliferation. The aim of the present study was to analyze the prognostic impact of SOX9 in stage II colon cancer. Methods: Individual patient data and formalin fixed paraffin embedded tumor tissue were collected from a large unbiased, population-based cohort, representing all patients operated for stage II colon cancer in Denmark in 2002 and 2003. The SOX9 expression was evaluated by immunohistochemistry on whole tumor sections. Patients were classified into three groups dependent on the SOX9 expression gradient in the tumor: luminal, peripheral, and uniform for comparison with the clinical data. The endpoint was disease free survival (DFS). Results: A total of 1,153 patients were included. We detected an expression-dependent relationship between SOX9 and prognoses. Patients with tumors exhibiting a luminal expression pattern (N = 267, increasing SOX9 expression towards the luminal compartment of the tumor) were characterized by a significantly better DFS compared to the uniform (N = 846) and peripheral (N = 40) patterns, p = 0.0070. The five-year DFS rates were 74%, 67%, and 56%, respectively. Multiple Cox regression analysis, adjusted for all standard high risk factors, confirmed an independent prognostic advantage of the luminal SOX9 expression pattern, as compared to the uniform pattern, hazard ratio (HR) 0.7211 (95% confidence interval (CI) 0.5561-0.9351), p = 0.0137, whereas the possible disadvantage of the periphery pattern could not be verified, HR 1.4393 (95% CI 0.8869-2.3660), p = 0.1405. Conclusions: The present results support a prognostic impact of SOX9 in stage II colon cancer. The consequence of an altered SOX9 expression seems to differ between intra-tumoral compartments, and we propose that a gradient-dependent evaluation should be applied to provide the most clinically relevant information about this transcription factor.
Adult Advanced Life Support: 2020 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations
Authors: Katherine M. Berg, Jasmeet Soar, Lars W. Andersen, Bernd W. Böttiger, Sofia Cacciola, Clifton W. Callaway, Keith Couper, Tobias Cronberg, Sonia D’Arrigo, Charles D. Deakin, Michael W. Donnino, Ian R. Drennan, Asger Granfeldt, Cornelia W.E. Hoedemaekers, Mathias J. Holmberg, Cindy H. Hsu, Marlijn Kamps, Szymon Musiol, Kevin J. Nation, Robert W. Neumar, Tonia Nicholson, Brian J. O’Neil, Quentin Otto, Edison Ferreira de Paiva, Michael J.A. Parr, Joshua C. Reynolds, Claudio Sandroni, Barnaby R. Scholefield, Markus B. Skrifvars, Tzong-Luen Wang, Wolfgang A. Wetsch, Joyce Yeung, Peter T. Morley, Laurie J. Morrison, Michelle Welsford, Mary Fran Hazinski, Jerry P. Nolan, Mahmoud Issa, Monica E. Kleinman, Giuseppe Ristagno, Julie Arafeh, Justin L. Benoit, Maureen Chase, Bryan L. Fischberg, Gustavo E. Flores, Mark S. Link, Joseph P. Ornato, Sarah M. Perman, Comilla Sasson, Carolyn M. Zelop
Journal: Circulation (2020)

This 2020 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations for advanced life support includes updates on multiple advanced life support topics addressed with 3 different types of reviews. Topics were prioritized on the basis of both recent interest within the resuscitation community and the amount of new evidence available since any previous review. Systematic reviews addressed higher-priority topics, and included double-sequential defibrillation, intravenous versus intraosseous route for drug administration during cardiac arrest, point-of-care echocardiography for intra-arrest prognostication, cardiac arrest caused by pulmonary embolism, postresuscitation oxygenation and ventilation, prophylactic antibiotics after resuscitation, postresuscitation seizure prophylaxis and treatment, and neuroprognostication. New or updated treatment recommendations on these topics are presented. Scoping reviews were conducted for anticipatory charging and monitoring of physiological parameters during cardiopulmonary resuscitation. Topics for which systematic reviews and new Consensuses on Science With Treatment Recommendations were completed since 2015 are also summarized here. All remaining topics reviewed were addressed with evidence updates to identify any new evidence and to help determine which topics should be the highest priority for systematic reviews in the next 1 to 2 years.
Long-term treatment of cirrhosis related to HCV with lymphoblastoid IFN. Effct on disease activity and incidence of HCC L. Bolondi, S. Sofia. * L. Buscarini, UG. Fornaciari. *F. Fornari. UE. Castagnetti, L. Barbara and The Multicentric Study Group on IFN Therapy in Liver Cirrhosis
Journal: Hepatology (1995)
THE PLACENTAL BARRIER AND DRUGS
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A UNITED PROFESSION IN NEW YORK.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Interleukin-2 (IL-2) with 13-cis retinoic acid (RA) to prolong disease free and overall survival in metastatic colorectal cancer
Authors: F. Recchia, S. De Filippis, G. Saggio, A. Cesta, G. Amiconi, A. Di Blasio, S. Rea
Journal: Journal of Clinical Oncology (2004)

3629 Background: In a phase 1B study we established that low-dose IL-2 and 13-cis retinoic acid was not toxic and could be administered safely as maintenance therapy for patients (PTS) exhibiting response or disease stabilization to chemotherapy, but at a high risk of relapse (Clin Cancer Res 7: 1251–1257, 2001). A phase II study (Int J Oncol 20: 1275–82, 2002) showed the efficacy of such regimen in improving immunological parameters and in prolonging response in the same category of PTS. The objective of this phase II study was to verify whether the combination of IL-2 and RA could improve the outcome of PTS operated for colorectal cancer recurrence. Methods: 20 PTS (median age 66 years, 55% males, performance status 0–65%, 1–35%) were treated from September1998 to September 2001. Eight PTS had synchronous metastases, while 12 had a median disease-free survival of 14 months and had received a 5-fluorouracil (5-FU) leucovorin (LV) based adjuvant chemotherapy. After curative resection of metastases, PTS were treated for 6 months with oxaliplatin/5-FU/LV. After chemotherapy PTS received IL-2, 1.8 x 106 I.U. plus RA 0.5 mg/Kg for 5 days/week for 2 consecutive cycles of 3 weeks, with a 1-week rest, for up to 3 years. PTS were monitored every 2 months by determination of vascular endothelial growth factor (VEGF), CD4/CD8 ratio, NK and tumor markers, with response assessed every 4 months. Results: The toxicity of IL-2 and RA was low. With a combination of surgery and chemotherapy, a 75% response rate was obtained (95% C.I., 51%–91%). After a median follow-up of 20 months, median time to progression and overall survival were not reached yet. The 5-year survival rate was 52%. There was an improvement of all immunological parameters controlled over time (CD4/CD8, NK, decrease of VEGF). Conclusions: Compared to historical controls, IL-2 and RA therapy improves the DFS and overall survival after curative resection of metastases from colorectal cancer. A phase III randomized trial has been started. No significant financial relationships to disclose.
Prevalence estimates for primary brain tumors in the United States by behaviour and major histology groups
Authors: Faith G. Davis, Varant Kupelian, Sally Freels, Bridget McCarthy, Tanya Surawicz
Journal: Neuro-Oncology (2001)

Prevalence rates are used to supplement descriptions of disease and are unavailable for all primary brain tumors in the United States.Data from two population-based tumor registries were obtained from the Central Brain Tumor Registry of the United States and used to compute age-speci c incidence rates (1985-1994) and survival curves for further use in a statistical model to estimate prevalence rates.Prevalence rates were then used to estimate the number of individuals living with a brain tumor diagnosis in the U.S. population for the year 2000.The overall incidence rate in these regions is 13.8 per 100,000 with 2-, 5-, and 10-year survival rates of 58%, 49%, and 38%, respectively.The prevalence rate for all primary brain tumors is 130.8 per 100,000 with approximately 350,000 individuals estimated to be living with this diagnosis in the United States in 2000.The prevalence rate for malignant tumors, 29.5 per 100,000, is similar to previous reports.The prevalence rate for benign tumors, 97.5 per 100,000, is new.Unlike incidence data, the proportion (and expected number) of existing benign tumors (75%, 267,000) is considerably greater than that for malignant tumors (23%, 81,000), re ecting the better prognosis of benign tumors diagnosed in individuals younger than 60 years old.These data underscore the impact of primary brain tumors in the U.S. health care system and emphasize the need for quality-of-life considerations, particularly for those long-term survivors of benign tumors.
Inflammatory Bowel Disease Is More Common Than Earlier Studies Showed
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Serum Enzymes During Recovery from Malnutrition
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Identification of a Potent Natural Triterpenoid Inhibitor of Proteosome Chymotrypsin-Like Activity and NF-κB with Specific Anti-Myeloma Activity in Vitro and in Vivo
Authors: Rodger E. Tiedemann, Jonathan J Keats, Jessica Schmidt, Chang-Xin Shi, Yuan X Zhu, Xinliang Mao, Aaron D. Schimmer, Keith Stewart
Journal: Blood (2008)
Deserted Island
Authors: John W. Burnside
Journal: JAMA (1991)

I have a fantasy about a deserted island. This island is temperate, is well provisioned with water, fruits, and vegetables, and perhaps has good fishing. A safe place but no communications, no people, maybe a dog or a goat, and no way off save by a visiting ship once a twelvemonth. In this fantasy I have control of the residency requirements and the passenger manifest of the visiting steamer. I can write the prescription, which reads: Rx: One deserted island One year Sig: As directed No refills While I'm at it, and since this is fantasy, let me have as many of these islands as needed, since I'd have trouble were I forced to choose among the many who might benefit. Such a prescription could be life-giving, even lifesaving. A kind of Statue of Liberty for the weak, tired, and dizzy, for the yearning souls eager to be cocooned lest
A crisis in medical education. Thoughts on listening to a conference on medical education for the 21st century
Authors: J. V. Warren
Journal: JAMA (1985)

ON MARCH 1 and 2, 1984, the faculty of The Ohio State University College of Medicine, Columbus, celebrated its sesquicentennial by holding a conference, with nine distinguished speakers, entitled Medical Education for the 21st Century.<sup>1</sup>It occurred to us, the major architects of this symposium, that it might be useful to record a consolidated and somewhat impressionistic view of what we learned. This article represents our reflections, as stimulated by both formal talks and informal discussions, during this excellent conference. <h3>THE WORLD OF MEDICINE AS IT MOVES THROUGH TIME</h3> Much discussion at the conference focused on the global concept of the "world of medicine": the world in which medical education takes place. No totally satisfactory term can be found for this large and complex "world of medicine." It includes such components as biomedical science; medical practice; the entire health care delivery system; medical economics; health professions education; the public's perceptions
Water Lilies
Authors: M. Therese Southgate
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
On saying good-bye before death
Authors: R. A. Meares
Journal: JAMA (1981)

IN RECENT years, increasing importance has been given to the role of the physician and his colleagues, not only in preserving life, but in easing the process of dying. Accumulated evidence suggests this is not solely for the comfort of the dying, but also for the health and well-being of the survivors. The social and psychological processes surrounding death are presumably universal, but more easily discerned in previous centuries and in cultures other than our own. The farewell is an element that is implied but not often described specifically in well-known works on this subject.<sup>1</sup>This aspect of dying is enshrined in the myth of the Old Man Nagacork, as told by the aborigines in the Roper River district of the Northern Territory of Australia. And the old man Nagacork went on a long walkabout to see all the blackfellows, the birds, animals, fish and reptiles. And as Nagacork