tbuckley/cabot-search huggingface dataset:
Home blood pressure determination. Value in borderline ("labile") hypertension
Authors: S. Julius
Journal: JAMA (1974)

Self-determined home blood pressure readings taken by 112 patients with borderline hypertension were compared to values of 49 normotensive controls. Thirty percent of patients with borderline hypertensive readings in the clinic were hypertensive at home; only 28% of patients were clearly normotensive. Clinic blood pressure levels, family history, body weight, and heart rate failed as predictors of which patients were likely to be hypertensive at home. Self-determined home blood pressures are suggested for identification of individual patients with borderline hypertension who require continuous and close observation. (<i>JAMA</i>229:663-666, 1974)
Significance of Plasma Lead Levels in Normal and Lead-Intoxicated Children
Authors: John F. Rosen, Emma E. Trinidad
Journal: Environmental Health Perspectives (1974)

Plasma lead (Pb) levels have been measured in normal and lead-intoxicated children, newborns, and children with sickle cell disease.The results in all groups were contant over a wide range of red cell Pb concentration.These results support the thesis that the red cell represents a large repository for Pb, maintaining plasma Pb concentration within closely defined limits, and that methods other than measurements of plasma Pb will be necessary to uncover a presumably dynamic transport system between red cell and plasma.Indeed, we have demonstrated in vitro that ionized calcium (Ca2+) lowers red cell Pb content according to a linear dose-response curve.Ca'+ may thereby control Pb transport from red cell to plasma, and fluctuations in the concentration of Ca`in serum and extracellular fluid may influence the toxic activities of Pb.In bone organ culture, changes in the concentration of Ca2+ and phosphate in the medium alter the release of previously incorporated 2"0Pb from fetal rat bones in response to parathyroid hormone (PTH).Therefore, both PTH and the ionic milieu of the medium apparently regulate bone Pb metabolism.We would expect that understanding further the dynamics of Pb transport in plasma and bone may lead to a more exact definition of the real hazards of low level Pb toxicity in children. PlasmaIn previous reports, the concentration of
Blood pressure changes following extracorporeal shock wave lithotripsy and other forms of treatment for nephrolithiasis
Authors: J. E. Lingeman
Journal: JAMA (1990)

Hypertension has been reported as a possible sequela of extracorporeal shock wave lithotripsy (ESWL). To evaluate this issue as well as the risk of hypertension following other current non-ESWL treatment options for urolithiasis (percutaneous nephrostolithotomy [PCNL], combined PCNL and ESWL, ureteroscopy, and spontaneous stone passage), detailed blood pressure measurements were made in 961 patients at least 1 year after treatment. All follow-up blood pressures were measured with random-zero blood pressure devices. This study includes 731 patients who received ESWL only (with an unmodified lithotriptor), 171 patients treated with ureteroscopy or spontaneous stone passage (control subjects), 25 patients who received PCNL only, and 34 patients treated with both ESWL and PCNL. In patients who received ESWL only, the annualized incidence of hypertension (2.4%) did not differ significantly from that in control patients (4.0%). Among patients who received ESWL, no correlation was found between the incidence of hypertension and unilateral vs bilateral treatments, the number of shock waves administered, the kilovoltage applied, or the power (number of shock waves times kilovoltage). However, there was a significant rise in diastolic blood pressure after treatment with ESWL (0.78 mm Hg), but not in the control group (—0.88 mm Hg). The long-term significance of this change in diastolic blood pressure following ESWL is unknown and requires further study. (<i>JAMA</i>. 1990;263:1789-1794)
Pediatric cyanide intoxication and death from an acetonitrile-containing cosmetic
Authors: E. M. Caravati
Journal: JAMA (1988)

Two cases of pediatric accidental ingestion of an acetonitrile-containing cosmetic are reported. One of the children, a 16-month-old boy, was found dead in bed the morning after ingesting the product. No therapy had been undertaken, as the product was mistakenly assumed to be an acetone-containing nail polish remover. The second child, a 2-year-old boy, experienced signs of severe cyanide poisoning, but survived with vigorous supportive care. Both children had blood cyanide levels in the potentially lethal range. The observed delayed onset of severe toxic reactions supports the proposed mechanism of acetonitrile conversion to inorganic cyanide via hepatic microsomal enzymes. Physicians and poison centers should be alerted to the existence of this highly toxic product, sold for removal of sculptured nails and likely to be confused with the less toxic acetone-containing nail polish removers. We urge regulatory agencies to reconsider the wisdom of marketing a cosmetic that poses such an extreme health hazard. (<i>JAMA</i>1988;260:3470-3473)
Report on medical licensure. Council on Medical Education
Authors: William E. Jacott, E. James Potchen, John E. Albers, John A. Baker, J. Lee Dockery, Karolyn J. Kramer, George T. Lukemeyer, Sam A. Nixon, William J. Reals, Frank A. Riddick, F. Douglas Scutchfield, Charles D. Sherman, Richard L. Egan, Council on Medical Education
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Alcoholism treatment research: new directions for an old problem
Authors: E. Gordis
Journal: JAMA (1989)

Unlike areas in medicine where the rigorous scientific evaluation of treatments before patient exposure has become standard, validating the effectiveness of various treatments for alcoholism is a fairly new enterprise. The study of the efficacy of lithium carbonate as a treatment for alcoholism by Dorus et al,<sup>1</sup>in this issue ofThe Journal, is highly encouraging since it demonstrates again that modern standards of treatment evaluation can be applied to alcoholism treatment.<sup>2</sup> Although earlier research in animals and in smaller-scale studies on human subjects had led to the hypothesis that lithium carbonate might be useful in treating alcoholics,<sup>3-5</sup>Dorus and colleagues, in their large-scale, multisite evaluation, found that lithium carbonate did not affect the course of alcoholism in either depressed or nondepressed alcoholics. In conducting their study, the authors avoided weaknesses common to many alcoholism treatment studies. Principal among these weaknesses are having too few subjects to
The Direction of Epithelial Growth
Authors: T. J. Ryan
Journal: British Journal of Dermatology (1970)

Journal Article The Direction of Epithelial Growth Get access T. J. Ryan T. J. Ryan Institute of Dermatology Homerton Grove, London, E9 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 83, Issue 1, 1 July 1970, Pages 217–218, https://doi.org/10.1111/j.1365-2133.1970.tb12887.x Published: 01 July 1970
Hospital Ventilation and Tuberculosis in Canadian Health Care Workers
Journal: Annals of Internal Medicine (2000)

Summaries for Patients21 November 2000Hospital Ventilation and Tuberculosis in Canadian Health Care WorkersSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-133-10-200011210-00005 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Tuberculosis is an infection that usually affects the lungs, but it can also affect other body organs. Tuberculosis spreads when a person with this lung infection coughs and releases tuberculosis bacteria into the air. When persons with tuberculosis are hospitalized, it is very important to use special precautions (masks and isolation rooms) to keep the infection from spreading to other patients and hospital workers. In the early 1990s, several outbreaks of tuberculosis in hospitals drew attention to this issue. New recommendations suggested strict infection control precautions, including special ... Author, Article, and Disclosure InformationThe summary below is from the full report titled “Hospital Ventilation and Risk for Tuberculous Infection in Canadian Health Care Workers.” It is in the 21 November 2000 issue of Annals of Internal Medicine (volume 133, pages 779-789). The authors are D Menzies, A Fanning, L Yuan, JM FitzGerald, and the Canadian Collaborative Group in Nosocomial Transmission of TB.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoHospital Ventilation and Risk for Tuberculous Infection in Canadian Health Care Workers Dick Menzies , Anne Fanning , Lilian Yuan , and J. Mark FitzGerald , and the Canadian Collaborative Group in Nosocomial Transmission of TB* Metrics 21 November 2000Volume 133, Issue 10Page: I-52KeywordsAir flowBacteriaHealth care providersHospital medicineLungsNosocomial infectionsRisk managementSkin testsTuberculosis ePublished: 21 November 2000 Issue Published: 21 November 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
REPLY:
Authors: Xiuwen Tang, Xiu Jun Wang
Journal: Hepatology (2020)

Potential conflict of interest: Nothing to report. This work was supported by the National Natural Science Foundation of China (31971188). We thank Jaeschke and Ramachandran for their interest in our study. First, our findings of the phosphorylation of nuclear erythroid 2 p45‐related factor 2 (Nrf2) and diminished mRNAs of NAD(P)H:quinone oxidoreductase 1 (Nqo1), glutathione S‐transferase A3 (Gstα3), glutathione S‐transferase M1 (Gstm1), glutathione S‐transferase M5 (Gstm5), and aldo‐keto reductase 1C (AKR1C) by 6 hours after acetaminophen (APAP) treatment (300 mg/kg) (Supporting Fig. S2B),(1) indicate that the Nrf2/Antioxidant responsive element (ARE) cytoprotective system is impaired from a very early time point. No significant changes in the protein levels were detected at the 6‐hour time point. However, this is not unexpected given that these enzymes are known to have a long half‐life. Although our study only examined the expression of 5 ARE‐driven genes, >200 genes have so far been identified as Nrf2 target genes. As suggested in the editorial by Kaplowitz, Than, and Win,(2) further studies are required to define the roles of Nrf2‐regulated genes in APAP‐induced liver injury. In addition, we disagree with the suggestion that glutathione levels are a functional readout of ARE activation. Buthionine sulfoximine, an inhibitor of glutamate‐cysteine ligase, catalytic subunit, depletes hepatic glutathione to an extent similar to APAP in vivo but is unable to activate Nrf2.(3) Next, in our study, immunohistochemistry analysis showed slightly stronger staining of phosphorylated (P‐)Nrf2 in cells surrounding the necrotic areas in most liver sections from mice treated with APAP, although the contrast of the staining in some sections was not pronounced, possibly because of the low level of P‐Nrf2 protein expression. However, in the same liver sections, we observed substantial staining of Nqo1, Gstα3, Gstm1, Gstm5, and AKR1C in the hepatocytes surrounding necrotic areas, probably because of the strong hepatic expression level of these enzymes, suggesting that the malfunction of the Nrf2/ARE system is zone‐specific. These data will be submitted for publication in the near future. Last, we agree that regulation of mitochondrial oxidant stress by c‐Jun N‐terminal kinase is the critical downstream event in APAP‐induced liver injury.(4) Nrf2 has been recently recognized as a prominent player in mitochondria function. Interestingly, Barzegari et al. (2020) reported that the mitochondria‐targeted antioxidant mito‐TEMPO activates Nrf2.(5) However, the contribution of Nrf2 to the regulation of mitochondrial oxidant stress in APAP‐induced liver injury remains unclear and warrants further study.
MOLLUSCUM SEBACEUM
Authors: HENRY MACCORMAC, R.. W SCARFF
Journal: British Journal of Dermatology (1936)

Journal Article MOLLUSCUM SEBACEUM Get access HENRY MACCORMAC, C.B.E, M.D., HENRY MACCORMAC, C.B.E, M.D. Search for other works by this author on: Oxford Academic Google Scholar R.. W SCARFF, M.B., B.S R.. W SCARFF, M.B., B.S Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 48, Issue 11, 1 November 1936, Pages 624–626, https://doi.org/10.1111/j.1365-2133.1936.tb10377.x Published: 01 November 1936
Effect of Treatment in Patients with Chronic Myelogenous Leukemia: Biochemical Studies
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Erratum to: Incidence, Prevention and Management of Anti-Drug Antibodies Against Therapeutic Antibodies in Inflammatory Bowel Disease: A Practical Overview
Authors: Pieter Hindryckx, Gregor Novak, Niels Vande Casteele, Reena Khanna, Debby Laukens, Vipul Jairath, Brian G. Feagan
Journal: Drugs (2017)
Abstracts
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Annals of Surgery, Philadelphia
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Erratum to: Transcriptional profiling of MnSOD-mediated lifespan extension in Drosophila reveals a species-general network of aging and metabolic genes
Authors: Christina Curtis, Gary N Landis, Donna Folk, Nancy B Wehr, Nicholas Hoe, Morris Waskar, Diana Abdueva, Dmitriy Skvortsov, Daniel Ford, Allan Luu, Ananth Badrinath, Rodney L. Levine, Timothy J. Bradley, Simon Tavaré, John Tower
Journal: Genome biology (2016)
FDA pushes for prescription drug information
Authors: C. Marwick
Journal: JAMA (1995)

HEALTH CARE providers, including physicians, pharmacists, and private medical groups, have 5 more years to reach the goal of providing three fourths of their patients with adequate information about prescription drugs. If they don't, the Food and Drug Administration (FDA) will step in and make a patient education program mandatory. This warning was delivered by FDA Commissioner David A. Kessler, MD, at the 10th National Conference on Prescription Medicine Information and Education (NCPIE), held in Washington, DC, last month. "If during the next 5 years we reach this objective, we will know we are on the right track," Kessler said. The NCPIE was created 13 years ago for the express purpose of educating patients about the prescription medicines they are told to take. Kessler's challenge is the latest step in a 20-year effort to provide adequate information to patients about the drugs their physicians prescribe and the correct way to
Toxic shock syndrome: back to the future
Authors: B. B. Dan
Journal: JAMA (1987)

In words that would transmit the heart-sinking fear of the contagion across 24 centuries, Thucydides dutifully chronicled the clinical features of the plague of Athens. The horrifying epidemic would not only kill tens of thousands of soldiers and civilians, it would alter the course of the Peloponnesian War, and change history. Although the awful spectacle was depicted as "men dying like sheep,"<sup>1</sup>the pestilence was notable for far more than just its numerical devastation. It was a bewildering constellation of signs and symptoms that no physician or historian had ever recorded before. Its victims, previously in good health, were suddenly stricken with high fever, sneezing, coughing, and hoarseness. They rapidly developed nausea, vomiting, and diarrhea, with a puzzling combination of conjunctival and oropharyngeal hyperemia and erythroderma. So unbearable was their fever that many of the sick plunged themselves into cooling water to relieve their "agonies of unquenchable thirst." Despite
Inadvertent hypothermia with metabolic acidosis and circulatory depression
Authors: W. A. Warner
Journal: JAMA (1967)

A 41/2-year-old white girl with tetrology of Fallot was admitted to the hospital because of persistent constipation and an abdominal mass of fluctuating size. One year prior to admission she had undergone a Brock transventricular pulmonary valvotomy, with considerable benefit. Interval cyanosis and squatting were now limited to periods of exertion. The preoperative workup revealed an abdominal mass, suspected to be a tubular duplication of the colon, and absence of the left kidney. Laparotomy was scheduled following bowel preparation with succinylsulfathiazole (Sulfasuxidine). Premedication consisted of pentobarbital, 60 mg; morphine sulfate, 2 mg; and scopolamine, 0.2 mg. Induction was achieved uneventfully with cyclopropane and oxygen, followed by a combination of nitrous oxide, oxygen, and halothane. An endotracheal catheter was inserted easily and connected to a Norman T-piece with reservoir bag. Anesthesia was maintained with a combination of nitrous oxide and oxygen (3.5:3.5 liters/min) and halothane (0.5% to 1.5%) added as
<i>Mind and Its Disorders</i>. A Text-Book for Students and Practitioners. By W. H. B. Stoddard, M. D., F. R. C. P., Resident Physician and Medical Superintendent Bethlem Royal Hospital, etc. Second Edition, with illustrations. (<i>Philadelphui: P. Blakiston's Son &amp; Co., 1912</i>.)
Journal: American Journal of Psychiatry (1913)
<i>The Kingdom of Evils Psychiatric Social Work Presented in One Hundred Case Histories Together with a Classification of Social Divisions of Evil.</i>By E. E. Southard, M. D. Late Bullard Professor of Neuropathology, Harvard Medical School; Director Boston Psychopathic Hospital, etc., and Mary C. Jarrett, Associate Director Smith College Training School for Social Work; formerly Chief of Social Service, Boston Psychopathic Hospital. With an Introduction by Richard C. Cabot, M. D., and a Note …
Authors: Karl A. Menninger
Journal: American Journal of Psychiatry (1923)