tbuckley/cabot-search huggingface dataset:
HUMAN THALLOTOXICOSIS
Authors: JAMES C. MUNCH
Journal: JAMA (1934)

In connection with an outbreak of thallium poisoning in California<sup>1</sup>the question arose regarding the frequency of human thallium poisoning. General reviews of the pharmacology of thallium,<sup>2</sup>as well as a number of scattered articles, have reported only single or a few cases. In the preparation of this compilation, efforts have been made to consult original articles publishedprior to January 1934. Reports in the literature are difficult to evaluate, since general statements regarding numbers of patients may include specific cases recorded by other writers. <h3>POISONING FROM INDUSTRIAL PRACTICE</h3> Following the original reports of Crookes in 1861 and of Lamy in 1863, thallium has been obtained from various ores, and from the flue dust of plants roasting pyrites or raw sulphur in manufacturing sulphuric acid.<sup>2b</sup>Prussian plants handling thallium answered questionnaires regarding industrial poisonings sent by Buschke<sup>3</sup>at the request of the minister of health.
Typhoid Fever
Authors: Jonathan M. Zenilman
Journal: JAMA (1997)

<h3>CASE PRESENTATION</h3> A 35-year-old Maryland woman came to her local hospital on December 4, 1994, complaining of fever and chills for 1 week. She was 25 weeks pregnant. Four weeks earlier, she and her husband and young daughter had visited relatives in a city about 320 km northwest of Bombay, India. She had not received pretravel vaccinations or malaria prophylaxis, and she did not take any specific food or water precautions while in India. She had felt well during the trip. She had returned to Maryland on November 24. On November 29, she developed fever and chills. Her private physician examined her that day and prescribed oral ampicillin to treat a sore throat. When her fever persisted, she was admitted to the local hospital on December 4. Evaluation included blood cultures and multiple Giemsa-stained thick smears for malaria. On December 5, a physician diagnosed malaria after identifying a<i>Plasmodium falciparum</i>parasite
Dermal In Vitro Penetration of Methiocarb, Paclobutrazol, and Pirimicarb: Effect of Nonylphenolethoxylate and Protective Gloves
Authors: Jesper Bo Nielsen, Helle Raun Andersen
Journal: Environmental Health Perspectives (2001)

Dermal exposure has become the major route of human occupational exposure to pesticides. Detergents are used as part of formulated pesticide products and are known to change the barrier properties of human skin in vitro. However, studies on the influence of detergents as well as protective glove materials on dermal penetration of pesticides are scarce. In an experiment using in vitro static diffusion cells mounted with human skin, we evaluated the effect of nonylphenol-ethoxylate on dermal penetration of three extensively used pesticides--methiocarb, paclobutrazol, and pirimicarb--and the protection against dermal penetration offered by protective gloves made of latex or nitrile. There was a general tendency, though not statistically significant for all pesticides, for nonylphenolethoxylate to decrease the percutaneous penetration of the three pesticides. The nitrile generally offered better protection against percutaneous penetration of pesticides than did latex, but the degree of protection decreased over time and depended on the pesticides used.
Chronic hepatitis C virus infection in haemophiliacs- a combined management protocol . Liver Unit and Haemophilia Unit, Queen Elizabeth Hospital, Birmingham, UK
Journal: Hepatology (1995)

Neuromyelitis optica (NMO) sometimes coexists with serological marker-positive, non-organ-specific autoimmune disorders. We evaluated the prevalence of thyroid dysfunction and anti-thyroid antibodies in patients with NMO spectrum disorder (NMOSD) and investigated the associations between thyroid dysfunction/autoimmunity and clinical features of NMOSD.Forty-nine NMOSD patients with anti-aquaporin-4 antibody and 392 age- and sex-matched healthy controls were included. We measured the levels of thyroid hormones and anti-thyroid antibodies.The prevalence of clinical hypothyroidism, subclinical hyperthyroidism, and low T3 syndrome were higher in patients with NMOSD (4.1%, 12.2%, and 20.4%, respectively) compared with healthy controls (0.3%, 2.8%, and 0.5%, respectively; p = 0.034, p = 0.001, and p < 0.001, respectively). However, anti-thyroperoxidase antibody (anti-TPO)-positivity did not significantly differ between NMOSD patients (20.4%) and controls (11.5%). Low T3 syndrome was more prevalent among patients during an attack (N = 10/19, 52.6%) than those in remission (N = 1/30, 3.3%). In addition, patients with low T 3 syndrome had significantly higher EDSS scores at the last visits as well as at sampling compared to those without low T3 syndrome. T3 levels were inversely correlated with EDSS score at the last visit after adjustment for age, sex, disease duration, clinical status (attack vs. remission), oral prednisolone use, iv methylprednisolone use, other immunosuppressive agents use, and the location of lesion (ρ = − 0.416, p = 0.010).Our study suggests that thyroid dysfunction is frequent in patients with NMOSD; particularly, serum T3 levels may be a useful indicator of disease activity and disability in NMOSD.
Immunologic Aspects of Endocrine Diseases
Authors: Gildon N. Beall
Journal: JAMA (1987)

ENDOCRINE organs seem predisposed to autoimmunity. This is particularly true for the thyroid gland, in which most of the common diseases are caused by immune mechanisms.<sup>1-3</sup>The evidence for participation of immune mechanisms in endocrine diseases is based on many observations. Organspecific antibodies or cell-mediated immune processes have often been found. The affected organ often contains lymphocytes that are suspected, and in some instances proved, to have the ability to synthesize autoantibody or damage tissue. A marked overlap of diseases and serological markers has been found both in individuals and in families. This evidence of genetic predisposition has been further underscored by the tendency for certain HLA haplotypes to be overrepresented in diseased individuals. Many of the diseases are more common in women than in men. Table 15-1 contains a list of endocrine diseases or syndromes that have been defined clearly enough for discussion in this chapter. <h3>THYROID DISEASES</h3>
Transactions of the Medical Association of the State of Alabama
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Acute budd-chiari syndrome: Spontaneously reversible exacerbation of hepatocellular necrosis but bad long-term prognosis H�pital Beaujon, 92110 Clichy, *H�pital L. Mourier, 92700 Colombes, and **Groupe Piti�-Salp�tri�re, Paris, France
Journal: Hepatology (1995)
Carbon Monoxide Poisoning From Hurricane-Associated Use of Portable Generators—Florida, 2004
Journal: JAMA (2005)

The four major hurricanes that struck Florida during August 13-September 25, 2004, produced electric power outages in several million homes. After the hurricanes, the Consumer Product Safety Commission (CPSC) investigated six deaths in Florida attributed to carbon monoxide (CO) poisoning (CPSC, unpublished data, 2004). The Florida Department of Health and CDC analyzed demographic and CO exposure data from these fatal poisoning cases and from nonfatal poisoning cases among 167 persons treated at 10 hospitals, including two with hyperbaric oxygen (HBO2) chambers. This report describes the results of that analysis, which determined that misplacement of portable, gasoline-powered generators (e.g., indoors, in garages, or outdoors near windows) was responsible for nearly all of these CO exposures. Public health practitioners should recognize that post-hurricane environments present challenges to the safe operation of portable generators and should educate the public on the hazards of CO poisoning in these settings.
Abstract 3346: Percutaneous Treatment Of Unprotected Left Main Coronary Stenoses With Paclitaxel-eluting Stents. Mid-term Results Of A French Prospective Multicenter Study (friend Register)
Authors: Didier Carrié, Hélène Eltchaninoff, Thierry Lefèvre, Marc Silvestri, Gérard Levy, Eric Maupas, P Brunel, B Glatt, Didier Blanchard
Journal: Circulation (2007)

Purpose : We assessed early and mid-term results of patients (pts) treated for ULMCA disease in the FRIEND registry. Methods: After ethical committee approval and informed consent, all consecutive pts with unprotected left main stenoses treated with Taxus stents were included in a multicenter prospective study from 23 centers. Major adverse cardiacl events (MACCE) : death, myocardial infarction, stroke, target lesion (TLR), target vessel revascularisation (TVR), acute, sub-acute and late thrombosis were adjudicated at 1and 6 months by an independent committee. Immediate and 9-month angiographic results were assessed by a central core lab. For the distal lesion of ULMCA, a strategy of main branch stenting with provisional T-stenting of the side branch followed by kissing balloon inflation was strongly recommanded. Results : From December 2005 to July 2006, 155 pts were included, mean age 68 ± 11 years, 83 % male, 31 % unstable angina, 25% diabetics, 46 % 3-vessel disease. The mean Euroscore was 4.2 ± 2.8 (estimated in-hospital mortality rate after surgery 4.1%). The LM reference diameter was 3.6 ± 0.5mm. LM lesion was ostial-proximal in 28 %,mid shaft 18 % and distal 66%. In this group, 72 % were located at the bifurcation including LAD, LCX or both ostia affected. All patients were successfully treated on the LM (stent length 15.7 ± 5.2 mm) and a final kissing balloon inflation was performed in 90%. Apart from the LM stenosis, a total of 1.2 ± 0.8 lesions were treated during the hospitalisation (total stent length 47 ± 16mm). In-hospital MACCE rate was 4.5 % : death in 2.6% (3 acute stent thrombosis at day 2, 3, 5 and 1 before PCI) ; 2 Pts had asymptomatic non-Q-wave MI,1 pt Q-wave MI and 1CABG. At 9-month follow-up (122 pts) there was one extra-cardiac death, no cardiac failure and 3 pts (2.5 %) had recurrence of symptoms. The global rate of event-free survival was 93.5 % with a very low angiographic restenosis rate of 3 %. Conclusion: LM PCI using the TAXUS stent is feasible and safe. Preliminary results showed favourable 9-month follow-up. Stenting deserves to be considered a safe and effective alternative to CABG in institutions performing large numbers of PCIs. Adjudicated clinical and angiographic long-term (9-month) data are warranted and will be available for presentation.
National policy development for the clinical application of genetic diagnostic technologies. Lessons from cystic fibrosis
Authors: B. S. Wilfond
Journal: JAMA (1993)

In recognition of the earlier experiences with genetic diagnostic services and in anticipation of a greater potential for genetic testing for presymptomatic disease and disease susceptibility, this article provides an analysis of policy development for cystic fibrosis carrier screening. The deficiencies of relying on an extemporaneous model for health policy development are described. Preferably, an evidentiary model, based on the evaluation of clinical research and incorporating professional and public attention to underlying normative issues, should define the standard of care. Appropriate procedural mechanisms should be established at both state and federal levels to prevent the unnecessary confusion, expense, and personal or social harms likely to result from a completely unrestrained application of developing genetic technologies or continuing ad hoc responses to rapid increases in genetic diagnostic capabilities. A broadly constituted national advisory commission on the ethical, legal, and social implications of the Human Genome Project would provide an important locus for national decision making and may offer an efficient mechanism for implementing the evidentiary model, promoting public involvement at a time when social policy decisions must be made to restructure the health care system to be more sensitive to issues of access, allocation, and costs. (<i>JAMA</i>. 1993;270:2948-2954)
Bradykinin-induced contraction of human peripheral airways mediated by both bradykinin B2 and thromboxane prostanoid receptors.
Authors: A Trifilieff, J P Gies
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

"Bradykinin-induced contraction of human peripheral airways mediated by both bradykinin B2 and thromboxane prostanoid receptors.." American journal of respiratory and critical care medicine, 151(5), pp. 1687–1688
Transtracheal Aspiration
Authors: STEPHEN G. PAUKER
Journal: Annals of Internal Medicine (1970)

Letters and Comments1 July 1970Transtracheal AspirationSTEPHEN G. PAUKER, M.D.STEPHEN G. PAUKER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-73-1-142_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The recent article by Hahn and Beaty (1) was a welcome substantiation of the validity of a technique that I have utilized with great success. It might be well to point out one potential danger of transtracheal aspiration and the usefulness of a closely related technique.If the intracatheter is introduced too deeply it may impinge on the posterior wall of the trachea, which may be lacerated if the patient moves or coughs. I am aware of one case where this resulted in an unrecognized hematoma in this position and lead to death by asphyxiation. This underscores...Reference1. HAHN H and BEATY H: Transtracheal aspiration in the evaluation of patients with pneumonia. Ann Intern Med 72:183-187, 1870 LinkGoogle Scholar1. MAY J and MAY D: Bacteriology of sputum in chronic bronchitis. Tubercle 44:162-173, 1963 CrossrefMedlineGoogle Scholar2. BRUMFITT W: An evaluation of sputum examination in chronic bronchitis. Lancet 2:1306-1309, 1957 CrossrefGoogle Scholar3. LEES A and MCNAUGHT W: Bacteriology of lower respiratory tract secretions in "normals" and chronic bronchitics. Lancet 2:1112-1115, 1959 CrossrefMedlineGoogle Scholar4. ALLIBONE E, ALLISON C, and ZINNEMANN K: Significance of H. influenzae in bronchiectasis of children. Brit Med J 1:1457-1460, 1956 CrossrefMedlineGoogle Scholar5. TURK D and MAY J: Haemophilus influenzae, Its Clinical Importance, London, The English Universities Press, Ltd., 1967, pp. 43-44 Google Scholar6. CHODOSH S: Examination of sputum cells. New Eng J Med 282:854-857, 1970 CrossrefMedlineGoogle Scholar7. Editorial: Transtracheal aspiration. New Eng J Med 269:203, 1963 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: STEPHEN G. PAUKER, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byINVASIVE PROCEDURES FOR DIAGNOSING PULMONARY INFECTIONUsefulness of transtracheal puncture and aspiration in the bacteriological diagnosis of pulmonary tuberculosisAnaerobic bacteriology of chronic bronchial disease 1 July 1970Volume 73, Issue 1Page: 142-143KeywordsTrachea ePublished: 1 December 2008 Issue Published: 1 July 1970 PDF downloadLoading ...
PTU-081 The impact of a nurse co-ordinated ibd multidisciplinary team meeting in enhancing safety and reducing cost
Authors: C Stansfield, A Robinson, S Lal
Journal: Gut (2015)

<h3>Introduction</h3> The management of biologic therapy in IBD poses many challenges to clinicians. The U. K. IBD Standards<sup>1</sup>have highlighted the need for a structured approach to the view of patients, but this can prove difficult as a result of limitations in outpatient capacity. The gastroenterology team aimed to evaluate the impact of a multidisciplinary team (MDT) meeting on clinical outcome and cost efficiencies. <h3>Method</h3> A one hour weekly MDT meeting was established to review all in-patients with IBD and those receiving biologic therapy. In addition, clinicians discussed cases that required additional opinions in management. This was attended by Consultant gastroenterologists, IBD Nurse Specialists, dieticians, junior medical staff and consultant surgeon. Outcomes from the meeting where recorded on a database and prospectively audited. <h3>Results</h3> Within a 6 month period the IBD team meet on 22 occasions. 257 patients where reviewed (120 male, 137 female median age 36 (16–77) with IBD (210 Crohn’s disease, 39 ulcerative colitis and 3 pouchitis and 5 IBDU). Biological therapy was reviewed in 182 cases, including 136 patients requiring a routine annual review of therapy. Of the latter group, biological therapy was continued in 112/182 (61%) cases, based on continued disease activity. 18/182 (9%) patients where referred for further investigation to evaluate response to treatment and 6 where referred for outpatient clinic review. Clinical management was reviewed in 46 patients, and subsequently 18/46 patients had treatment de-escalated or ceased as a result of clinical improvement or mucosal healing. 8 patients with adverse events were reviewed and a further 8 patients had their biologic changed. 2 where referred for discussion at the medical surgical MDT. Endoscopy referrals where requested in 20 cases, MR scan in 7 cases and an urgent clinic appointment in 23 cases. A further 75 patients raised for general discussion regarding clinical management. 10 were in-patients, and 3 were referred for surgical review, a further 7 had treatment progressed to anti-TNF therapy. 6 patients had endoscopic findings that required discussion. 30 patients where general discussion surrounding immunomodulating therapy. 7 patients had abnormal Liver function tests which required onward referral to hepatology. 22 patients had issues around general IBD management. Audit of compliance with NICE guidance improved from 80% to 100%. De-escalation of therapy and cessation of therapy accounted for a cost saving of £185,000 <h3>Conclusion</h3> The development of a nurse co-ordinated team meeting for IBD patients has facilitated a significant improvement in the overall quality of patient care, and has resulted in significant savings. <h3>Disclosure of interest</h3> None Declared. <h3>Reference</h3> <i>RCP standards for patients with inflammatory bowel disease</i>. London: Royal College of Physcians, 2013
Progress in Assessing the Long-term Outcome of Extremely Low-Birth-Weight Infants
Authors: Jon E. Tyson
Journal: JAMA (1996)

Despite the enormous effort of many investigators, a variety of problems have made it difficult to assess the long-term outcome of extremely low-birth-weight (ELBW [&lt;1000 g]) infants in a valid, meaningful, and useful manner. For example, partly because of limited support, most follow-up programs have included only the ELBW infants discharged from a specific center, including maternal and neonatal referrals, thus potentially introducing selection bias. Ideally, all ELBW infants born to residents of a defined geographic region should be evaluated. In addition, loss of 20% to 30% of infants to follow-up might substantially bias the observed rate of handicap because the lost infants may not be representative of the whole group. Such loss is difficult to avoid in following high-risk populations for more than a few years after birth. It is also important to assure that the assessment of preterm infants is not affected by examiner expectations or biases; therefore,
Secretory Cells of the Peripheral Pulmonary Epithelium as Targets for Toxic Agents
Authors: Gary E. R. Hook, Richard P. DiAugustine
Journal: Environmental Health Perspectives (1976)

The extracellular lining of the pulmonary peripheral airways is of vital importance to the lung. In this report, some aspects of the pulmonary extracellular lining and the epithelial cells believed to be responsible for its formation and secretion have been briefly reviewed. The influence of a number of toxic agents on the extracellular lining either directly or via those cells involved in its formation indicates that the extracellular lining may be important in understanding numerous toxic agent interactions with the lung.
Editorial: Jugular venous pressure.
Journal: BMJ (1974)

in rats and mice.The human tumour xenografts will no doubt remain of considerable interest for immunologists, and the tumour kinetics may become simplified when the immunologi- cal contribution to cell loss is severely impaired.The system may be a useful tool for the study of the metabolism of therapeutic agents by human tumours in vivo; however, it is unwise to suppose the drug pharmacokinetics will necessarily be the same in man.What is needed now is a critical assessment of present knowledge of the system and more intensive study of the biological problems that it presents.Those who support this line of research should not be overimpressed by the lack of immediate progress towards producing the answer to the clinicians' cri de coeur, for biological science rarely advances along a direct path.
Chlamydia Pneumoniae, Strain Twar Pneumonia
Authors: J. Grayston
Journal: Annual Review of Medicine (1992)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease 2019 (COVID-19), emerged in China in December 2019 and quickly spread around the globe, killing more than 4 million people and causing a severe economic crisis. ...Read More
Guest Authorship, Mortality Reporting, and Integrity in Rofecoxib Studies—Reply
Authors: Joseph S. Ross
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal