tbuckley/cabot-search huggingface dataset:
Ear, nose, and throat symptoms in subacute Wegener's granulomatosis.
Journal: BMJ (1989)

The standard description of Wegener's granulomatosis emphasises renal failure and thus a distorted impression may be given.Subacute and even chronic cases occur, and in these patients the presentation is varied and often insidious, leading to delay in diagnosis.Twenty two such patients (13 women and nine men) with a mean age of 44 years were seen in our connective tissue disease clinic.The mean duration of symptoms before diagnosis was 3-6 years and the mean duration of disease 5.9 years (19 years in one patient).All patients had malaise and ear, nose, and throat symptoms, and most had joint pains.Impaired renal function was seen in seven patients only.Tissue biopsy was diagnostic in half of the patients, and appreciably high titres of antineutrophil cytoplasmic antibodies were detected in only nine of 18 patients in whom these were measured.The most useful investigations were neutrophil counts, chest radiographs, and computed tomography of the sinuses and orbits.The most effective treatment was with intravenous pulses of cyclophosphamide.No deaths occurred.At the time of writing two patients were in remission and no longer being treated and 18 patients were in partial remission on continued treatment.Patients with subacute forms of Wegener's granu- lomatosis present with a variety of clinical features and the insidious presentation often leads to delay in diagnosis.A history of ear, nose, and throat symptoms was universal in our patients.
Eat, drink, and lower your cholesterol.
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PERSONAL EXPLOITATION THROUGH HEALTH PUBLICITY
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Want Panama Canal Physician.
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mortality among “never smokers” living with smokers: two cohort studies, 1981-4 and 1996-9
Authors: Sarah Hill, Tony Blakely, Ichiro Kawachi, Alistair Woodward
Journal: BMJ (2004)

Few studies have examined the association between passive smoking and all cause mortality; most of these have had limited study power. [1]2][3][4] We present results from two population cohorts of adults who had never smoked ("never smokers"), followed for three year mortality according to household exposure to secondhand smoke.
Not Indigestion
Authors: Eric L. Dyer
Journal: Annals of Internal Medicine (1992)

Ad Libitum15 August 1992Not IndigestionEric L. Dyer, MDEric L. Dyer, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-117-4-342 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Excerpt[To be read at a fast, anxious chant]10,000 doctors are dying. Only one will live. Notjust a headache. They are dying. 10,000 doctorshave a headache. Not indigestion. 10,000 dyingdoctors not sleeping. Know they are dying.Diplomas. Will burn their diplomas. 10,000dying doctors will burn their diplomas. Not sleeping.Dying. Working one more hour every day. Everyday more indigestion. Working one more hour.Have a headache. They have a headache. Someoneis watching. A headache. Someone is burning10,000 diplomas. All work. All those years of workgone. All those diplomas are dying. Someonewatching... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Nashville, TN 37203 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 August 1992Volume 117, Issue 4Page: 342-342KeywordsBurnsHeadaches ePublished: 1 December 2008 Issue Published: 15 August 1992 Copyright & Permissions©1992 American College of PhysiciansPDF downloadLoading ...
Heparin (Continued)
Authors: J. George Sharnoff
Journal: JAMA (1974)

<h3>To the Editor.—</h3> I agree with Dr. Wilson that the assay of heparin has always posed a difficult problem because the mechanism by which the hypercoagulable state develops from the pulmonary megakaryocytes is not appreciated. And whether one neutralizes heparin with protamine sulfate or checks whole blood coagulation with the highly unreliable Lee-White method or, as has been done for many years in England, with the Dale and Laidlaw coagulometer, the assay can be misleading, chiefly because the amount of clottable substance to be neutralized can vary. It is most important that heparin prophylaxis with the use of commercial heparin preparations of both beef and pork varieties has reduced fatalities to almost zero. This heparin prophylaxis is successfully monitored with the modified Dale and Laidlaw tube, maintaining levels at normocoagulation only. I believe our clinical success is what must convince others and not the speculative statements, if lives are to
ATTITUDE OF CHRISTIAN SCIENTISTS IN THE PRESENT EPIDEMIC OF INFLUENZA
Authors: C. B. Burr
Journal: JAMA (1918)

<h3>To the Editor:</h3> —Your optimistic current comment (The Journal, Oct. 12, 1918, p. 1223) concerning the change in attitude of the public toward public health methods would be highly reassuring if it were true in the measure that the comment indicates. You say, "When health authorities place a ban on public gatherings, when they insist that the windows of public conveyances be kept open, when they insist on absolute quarantine in order to stop the spread of the disease, the public is ready to obey, and does obey to the<i>fullest</i>measure" (italics mine). Further, "Another feature is the confidence of the public in public health authorities, apparently the result of the intense education of the public in prophylaxis of disease which has been going on during the past decade." I beg to call your attention to a special telegram to the Philadelphia<i>Public Ledger</i>, dated Boston, October 7, which
Systemic lupus erythematosus complicated by coccidioidomycosis
Authors: C. Z. Berry
Journal: JAMA (1968)

In 1950 this patient was treated with cortisone acetate for acute systemic lupus erythematosus (SLE). A state of remission was obtained until June 1963 when the patient moved to Tucson, Ariz. At this time, there was a relapse of the SLE. By Sept 30, pulmonary coccidioidomycosis developed, and by February 1964 the patient manifested the disseminated form of this disease. By Dec 15, a total of 2,285 mg of amphotericin B had been administered. Both diseases have remained in remission with residuals of nephrotic syndrome, persistent anemia, and leukopenia.
Early Vascular Risk Factor Modification in Type 1 Diabetes
Authors: Victor Sidel, Barry Levy
Journal: New England Journal of Medicine (2005)

in the right-hand column, lines 5 through 8 of the second full paragraph should have read, "N.meningitidis was responsible for 37 percent of the episodes, with group B identified in 174 episodes, group C in 79, group Y in 3, and group W135 in 1," rather than, "with group B identified in 173 episodes, group C in 79, group Y in 3, group H in 1, and group W135 in 1," as printed.
The role of the pneumatic antishock garment in penetrating cardiac wounds
Authors: B. Honigman
Journal: JAMA (1991)

<h3>Objective.</h3> —To determine the impact of the pneumatic antishock garment on survival in patients with cardiac wounds. <h3>Design.</h3> —A retrospective review of a 6.5-year experience in a population of patients with gunshot or stab wounds to the heart (N = 70). <h3>Setting.</h3> —The city and county of Denver, Colo, where all patients were transported by paramedic ambulances to Denver General Hospital, an urban, level 1 trauma center. <h3>Patients.</h3> —All patients were analyzed, including those transported to the emergency department with no vital signs at the trauma scene. Only patients with definite penetrating cardiac injuries were included. <h3>Methods.</h3> —Paramedic trip sheets and emergency department, operating room, in-hospital, and autopsy records were reviewed. Demographic, clinical outcome, and treatment data were collected. A multiple logistic regression model was developed to determine which characteristics and treatment variables were independently predictive of patient outcome. The ability of each independent variable to predict outcome was determined by calculating adjusted odds ratios (ORs) and 95% confidence intervals (CIs). <h3>Results.</h3> —Seventy patients (31 gunshot and 39 stab wounds) had a revised trauma score of 2.8 ± 4.0 (mean ± SD; range, 0-12; median, 0). Thirty-two (46%) had cardiac tamponade. Overall, 21 (30%) of the patients survived. In the logistic model, the presence of cardiac tamponade (OR, 9.1; 95% CI, 1.5 to 56.1) and a higher revised trauma score were associated with higher survival. Inflation of the pneumatic antishock garment was associated with sevenfold lower survival (adjusted OR, 0.14; 95% CI, 0.02 to 0.86); the effect was negative across all trauma score groups. <h3>Conclusion.</h3> —Survival in patients with penetrating cardiac wounds is highly associated with anatomic and physiologic factors, while application of the pneumatic antishock garment appears to be detrimental. (<i>JAMA</i>. 1991;266:2398-2401)
Before the Fire Department of the City of New York, Board of Hazardous Trades. In the Matter of the Hearing Relative to Proposed Classification and Passage of Rules and Regulations in Connection with the Refrigerant Freon (Dichloro-Difluoro-Methane—Also Known as F-12 and K-12).
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Painless thyroiditis.
Authors: G A MacGregor
Journal: BMJ (1977)

One assumes that the women were told of possible metabolic side effects from continuous intake of synthetic hormones, including amenorrhoea after stopping the regimen-as also can occur with the 12-week contraceptive injection.In view of the increasing incidence of postpill amenorrhoea following the monthly pill- taking regimen would it not have been more ethical in this experiment to have excluded women of parity 0 ?ELIZABETH ELLIOTT Wisbech, Cambs
Abstract LB-133: Tumor-promoting activity of CCL8 in involution-associated breast cancer
Authors: Eleni Farmaki, Vimala Kaza, Ioulia Chatzistamou, Hippokratis Kiaris
Journal: Cancer Research (2019)

Abstract Postpartum breast cancers that develop within 5 years after child birth have a poor prognosis because of increased risk of metastasis and remain a principal cause of mortality for young women. Therefore understanding the molecular physiology of postpartum breast cancers is imperative as it may provide novel therapeutic options. The increased risk for breast cancer immediately after pregnancy is linked to the extensive remodeling of the mammary gland that is designated as mammary involution. Immune cells such as macrophages and neutrophils, activated by a chemokine and cytokine cascade during involution, are actively involved in mammary gland remodeling and contribute to the disease development. Among the various chemokines activated in involution, the role of CCL8 in the development of postpartum breast cancer has not been addressed despite recent evidence demonstrating its role in metastatic disease. Our results show that CCL8 mRNA and protein levels increase in mammary gland during involution. Tumor growth studies involving CCL8-deficient animals that had been implanted with cancer cells prior to pregnancy or during involution indicated that CCL8 is tumor-promoting specifically following lactation, during involution. CCL8 is responsible for recruiting F4/80-positive macrophages to the mammary gland during the second phase of involution. Thus we asked if CCL8 promotes tumor development by recruiting macrophages in the involuting mammary gland. Our studies showed that CCL8 attracts primarily M2 type macrophages and that depletion of macrophages by liposomal clodronate abolished the tumor-promoting effect of CCL8 in the wt animals but did not affect CCL8KO animals, at which the M2 macrophages were already absent. These results illustrate the role of CCL8 in the development of postpartum breast cancer by recruiting M2 macrophages and suggest the potential value of targeting CCL8 for disease management. Citation Format: Eleni Farmaki, Vimala Kaza, Ioulia Chatzistamou, Hippokratis Kiaris. Tumor-promoting activity of CCL8 in involution-associated breast cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr LB-133.
Reflections on the Doctor's Anguish
Authors: Steven M. Scharf
Journal: Annals of Internal Medicine (1993)

Letters1 January 1993Reflections on the Doctor's AnguishSteven M. Scharf, MD, PhD, Harry N. Steinberg, MD, and Harly Greenberg, MDSteven M. Scharf, MD, PhDLong Island Jewish Medical Center; New Hyde Park, NY 11042Search for more papers by this author, Harry N. Steinberg, MDLong Island Jewish Medical Center; New Hyde Park, NY 11042Search for more papers by this author, and Harly Greenberg, MDLong Island Jewish Medical Center; New Hyde Park, NY 11042Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-118-1-199301010-00030 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We are grateful to Drs. Edwards and Tolle, two caring, competent physicians who wrote of their anguish in disconnecting a fully competent, ventilator-dependent patient from the ventilator at the patient's request [1]. Their courageous and candid presentation has given us much cause for thought, reflection, and some consternation.What are the limits of patient autonomy? The patient did not appear to suffer from a terminal illness except for ventilatory insufficiency of neuromuscular cause. After a week of intense and time-consuming consideration, the physicians were satisfied that their patient wished to die rather than be ventilator-dependent. How was ...References1. Edwards MJ, Tolle SW. Disconnecting a ventilator at the request of a patient who knows he will then die: the doctor's anguish. Ann Intern Med. 1992; 117:254-7. Google Scholar2. Rogers FB. A Syllabus of Medical History. Baltimore, Maryland: Waverly Press, Inc.; 1960:2. Google Scholar Author, Article, and Disclosure InformationAffiliations: Long Island Jewish Medical Center; New Hyde Park, NY 11042 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 January 1993Volume 118, Issue 1Page: 78-80KeywordsAntibioticsAnxietyEmotionsHealth carePotassium chlorideSedationSuicideVentilators ePublished: 15 August 2000 Issue Published: 1 January 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Covered vs. uncovered self-expandable metal stents for malignant distal biliary strictures: a systematic review and meta-analysis
Authors: Alberto Tringali, Cesare Hassan, Matteo Rota, Marta Rossi, Massimiliano Mutignani, Lars Aabakken
Journal: Endoscopy (2018)

Abstract Background Self-expandable metal stents (SEMS) are used for palliation of distal malignant biliary strictures, but the role of covered SEMS is less clear. We performed an up-to-date meta-analysis to compare the performance of covered and uncovered SEMS in patients with unresectable distal malignant biliary strictures. Methods A computerized medical search was performed using MEDLINE, EMBASE, and the Cochrane Library between 2000 and December 2016 to identify all randomized trials that compared covered with uncovered SEMS in patients with distal malignant biliary strictures. Primary outcomes were stent failure and patient mortality; secondary outcomes were stent dysfunction and adverse events. Pooled estimates were computed using the random effects model. Results Overall, 11 RCTs involving 1272 patients were included. The primary outcomes of stent failure and patient mortality did not differ significantly between covered and uncovered SEMS (hazard ratio [HR] 0.68, 95 % confidence interval [CI] 0.40 – 1.17; HR 0.89, 95 %CI 0.76 – 1.05, respectively). However, stent migration and sludge formation were much more common with covered SEMS (odds ratio [OR] 5.11, 95 %CI 1.84 – 14.17; OR 2.46, 95 %CI 1.37 – 4.43). The use of covered SEMS was associated with a lower rate of tumor ingrowth (OR 0.21, 95 %CI 0.09 – 0.50) but a higher rate of tumor overgrowth (OR 2.00, 95 %CI 1.15 – 3.48) compared with uncovered stents. The rates of procedure-related adverse events were similar in both groups. Conclusion There was a risk reduction of about 32 % for both stent failure and patient mortality with covered SEMS but this difference was not significant. Migration and sludge rates were higher with covered SEMS, whereas tumor ingrowth was more likely with uncovered SEMS. The data show no added benefit of covered SEMS; further stent evolution is desirable.
Multilevel care. A Veterans Administration initiative in health care cost control
Authors: J. Mulhearn
Journal: JAMA (1979)

The Veterans Administration's (VA) Department of Medicine and Surgery, the largest of the civilian federal health care systems, is under continuous White House, congressional, and public pressure to provide greater accountability and increased cost-effectiveness for its $5 billion-plus annual budget. Responding to these pressures, the VA is evaluating in ten of its 172 medical centers a new system of resource allocation and financial management known as a multilevel care system. This is a major VA initiative with highly important implications for both the VA and the private health care sector. (<i>JAMA</i>242:1285-1287, 1979)
Has the prognosis of idiopathic dilated cardiomyopathy improved in the community? The heart muscle disease registry of trieste Andrea Di Lenarda, Gastone Sabbadini, Roberto Gortan, Elisa Carniel, Mauro Driussi, Cristiana Zanchi, Cinzia Di Chiara, Milla Davanzo, Giulio Scherl, Gianfranco Sinagra. Department of Cardiology, Trieste, Italy
Journal: Journal of the American College of Cardiology (2001)
Positron-Emission Tomographic Scanning of Primary and Metastatic Breast Carcinoma with the Radiolabeled Glucose Analogue 2-Deoxy-2-[<sup>18</sup>F]Fluoro-<scp>d</scp>-Glucose
Journal: New England Journal of Medicine (1991)

Correspondence from The New England Journal of Medicine — Positron-Emission Tomographic Scanning of Primary and Metastatic Breast Carcinoma with the Radiolabeled Glucose Analogue 2-Deoxy-2-[18F]Fluoro-d-Glucose