tbuckley/cabot-search huggingface dataset:
CORRECTION
Journal: JAMA (1965)

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Acute Coronary Syndromes
Authors: Janet M. Torpy
Journal: JAMA (2008)

Acute Coronary SyndromesA cute coronary syndromes (ACS) is a term used to describe a group of conditions resulting from acute myocardial ischemia (insufficient blood flow to heart muscle) and ranging from unstable angina (increasing, unpredictable chest pain) to myocardial infarction (heart attack).The conditions are related to varying degrees of narrowing or blockage of single or multiple coronary arteries that provide blood, oxygen, and nutrients to the heart.This life-threatening disorder is a major cause of emergency medical care and hospitalization.Coronary artery disease (CAD) remains the leading cause of death in the United States.The July 2, 2008, issue of JAMA includes an article about treatment of acute coronary syndromes in men and women.This Patient Page is based on one previously published in the August 15, 2007, issue of JAMA.
Favorable outcome with hyper-CVAD in lymphoblastic lymphoma (LL)
Authors: D. A. Thomas, J. Cortes, S. M. O'Brien, F. Giles, S. Faderl, S. Verstovsek, A. Ferrajoli, M. Beran, F. Cabanillas, H. Kantarjian
Journal: Journal of Clinical Oncology (2004)

6597 Background: Outcome with LL has improved with use of more intensive chemotherapy regimens designed for acute lymphoblastic leukemia (ALL). Methods: From April 1992 to November 2001, 33 patients (pts) with newly diagnosed LL were treated with standard (n=22) [Kantarjian et al, J Clin Oncol 15:547, 2000] or modified (n=11) [Thomas et al, Blood 102:880a, 2003] hyper-CVAD regimens. Courses of hyper-fractionated cyclophosphamide, vincristine, doxorubicin and dexamethasone were alternated with methotrexate (MTX) and ara-C. The modified regimen inserted liposomal daunorubicin and ara-C for course 2. Mediastinal irradiation (XRT) was planned for bulky mediastinal disease. Intrathecal CNS prophylaxis alternated MTX and ara-C on days 2 and 7 of the first 3–4 courses. POMP (6-MP, vincristine, MTX, prednisone) maintenance was given for at least 2 years, interrupted by intensifications (MTX/asparaginase with or without hyper-CVAD depending on regimen). Results: Median age was 28 yrs (range, 17–59) and 82% were males. 70% had mediastinal disease and 30% had pericardial and/or pleural effusions. Two pts had superior vena cava syndrome and 3 had CNS disease. T-cell immunophenotype was present in 80%. Five (15%) pts had bone marrow involvement. XRT was given to 74% with mediastinal disease. Overall complete remission (CR) rate was 91% (rest with mediastinal disease not qualifying for CR). With median follow-up of 48 months (range, 8 to 110+ months), 23 (70%) pts remained alive without disease. Ten pts progressed within a median of 13 months (6 with standard, 4 with modified hyper-CVAD). Shorter progression-free survival (PFS) was seen in pts with CNS disease at presentation. Three-year PFS was 77% for standard hyper-CVAD and 62% for the modified regimen. Three pts were successfully salvaged with allogeneic SCT. Conclusions: Hyper-CVAD is a highly active regimen which improves outcome in LL compared with conventional ALL regimens. Anthracycline intensification does not appear to improve outcome compared with standard hyper-CVAD. Incorporation of newer agents such as Campath and nelarabine could be considered for slow responders or those with residual mediastinal disease. No significant financial relationships to disclose.
Antifungal Prophylaxis in AML Patients Receiving Intensive Induction Chemotherapy. Prospective Observational Study from the Acute Leukemia French Association (ALFA) Group
Authors: Mauricette Michallet, Mohamad Sobh, Alexandre Deloire, Emmanuel Raffoux, Stephane de Botton, Denis Caillot, Oumedaly Reman, Stephane Girault, Celine Berthon, Francoise Huguet, Stephane Lepretre, Thibaut Leguay, Sylvie Castaigne, Bruno Royer, Cecile Pautas, Jean-Valere Malfuson, Jose Fernandes, Thomas Prebet, Thorsten Braun, Lauris Gastaud, Felipe Suarez, Aline Schmidt, Remy Gressin, Jacques Delaunay, Caroline Bonmati, Karine Celli-Lebras, Mohamed El-Hamri, Herve Dombret, Xavier Thomas, Anne Bergeron
Journal: Blood (2016)
Interpreting Ultrasonograms
Authors: D. Gordon
Journal: BMJ (1972)

<h3>Abstract</h3> <h3>Background</h3> Elderly SARS-CoV-2 patients are associated with higher hospitalization and mortality. Co-infection is critical in the severity of respiratory diseases. It is largely understudied for SARS-CoV-2. <h3>Methods</h3> Between March 24<sup>th</sup> and April 27<sup>th</sup>, 2020, nasopharyngeal and oropharyngeal swabs from 3,348 patients from nursing homes and assisted living facilities in 22 states in the US were tested by Capstone Healthcare for SARS-CoV-2, 24 other respiratory viruses, and 8 respiratory bacteria. Total nucleic acid was extracted with MagMAX™ Viral/Pathogen Ultra nucleic acid isolation kit. SARS-Co-V-2 was detected with the CDC 2019-novel coronavirus (2019-nCoV) diagnostic panel. Total nucleic acid was pre-amplified before analysis for other respiratory pathogens with Taqman OpenArray™ Respiratory Tract Microbiota Plate. <h3>Results</h3> Patients’ mean age was 76.9 years. SARS-CoV-2 was detected in 1,413 patients (42.2%). Among them, 1,082 (76.6%) and 737 (43.7%) patients were detected with at least one bacterium or another virus, respectively. SARS-CoV-2-positive patients were more likely to have bacterial co-occurrences (76.6%) than SARS-CoV-2-negative patients (70.0%) (p&lt;0.0001). The most common co-occurring bacteria were <i>Staphylococcus aureus</i> and <i>Klebsiella pneumonia</i>, detected in 55.8% and 40.1% SARS-CoV-2-positive patients, respectively. <i>Staphylococcus aureus</i> was associated with SARS-CoV-2, with higher detection rates in SARS-CoV-2-positive patients (55.8%) than SARS-CoV-2-negative patients (46.2%) (p&lt;0.0001). Human herpes virus 6 (HHV6) also was common and associated with SARS-CoV-2, with higher detection rates in SARS-CoV-2-positive patients (26.6%) than SARS-CoV-2-negative patients (19.1%) (p&lt;0.0001). <h3>Conclusions</h3> SARS-CoV-2-positive patients are more likely to be positive for certain respiratory bacteria and viruses. This observation may help explain high hospitalization and mortality rates in older patients.
TYPHOID FEVER IN INFANTS.
Authors: I.N. LOVE
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sexology
Authors: Domeena C. Renshaw
Journal: JAMA (1984)

Courageous contemporary researchers have brought 20th-century medicine out of its total illiteracy regarding human sexuality. With various techniques—motion pictures, video recordings, electroencephalography, electrocardiography, electromyography, plethysmography, and measurements of pulse rates and pupil dilation—individuals (awake and asleep) and sexually interacting individuals and couples have been studied. In laboratory settings in the United States, England, France, Yugoslavia, and Scandinavia, sexual mysteries have yielded to study, providing knowledge about the sexual behavior and biology of men and women from womb to tomb. Some clinical problems are now successfully treated; the long-range goal is prevention of sexual difficulties, dysfunctions, and deviations.<sup>1,2</sup>Skepticism as well as criticism exist about medical sexual research and treatment of sexual problems, yet sexual medicine today inevitably spans every specialty from embryology to pharmacology.<sup>3</sup>Incest, long underemphasized in medical training, is beginning to receive serious study.<sup>4</sup> Before either prevention or treatment of sexual problems can be discussed,
Adverse Drug Reactions. Their Prediction, Detection and Assessment.
Journal: Annals of Internal Medicine (1973)

This little book, finely edited and presented, is a collection of well-illustrated essays, not comprehensive, but most comprehensible, an introduction and a stimulus.Unlike many symposia, it gives a thorough account of its subject, though inevitably there are weaknesses.The account of monitoring adverse reactions by industry before marketing seems to skirt round all the actual problems, at least those visible from without the industry, so that they seem from this account to be really very few.It was also good fun to learn in Chapter 5 that the Committee on Safety of Medicines is slow to report news of adverse 1 reactions to the industry.There may be another side to that story.There are many good ideas, ably discussed.The therapeutic audit (O.L.Wade), the adverse reactions information centre, an adverse reactions column or index in major journals, and a ward-wall card system (from D. M. Davies) are all important practical ideas.So is the 'adverse reaction profile' method discussed by W. Inman.There is a splendid defence of retrospective analyses by Sir Richard Doll, alongside an account of the limitations of prospective
Ventilation-perfusion mismatching in acute severe asthma: effects of salbutamol and 100% oxygen
Journal: Thorax (1989)

some useful shorter chapters on the general approach to diagnosis in given areas.Many of the sections and chapters are small monographs in their own right: 150 pages are devoted to respiratory physiology (and a further 70 to pulmonary function testing) and 50 page chapters to viral infections and mycobacterial disease, all backed by extensive bibliographies.The layout and illustrations are in general admirably clear, though some radiographs fail to make their point in reproduction.This impressive textbook sets out the enormous information base now available in respiratory medicine, which the patient hopes underpins our approach to practical diagnosis and management.If this increase in basic information is followed by a similar scale of advance in treatment, subspecialisation cannot be far over the horizon- NBP
Determining Handedness
Authors: Wulfred Berman
Journal: JAMA (1977)

<h3>To the Editor.—</h3> The letter by Drs Pittsley and Shearn (236:819, 1976) correctly emphasizes the low sensitivity of thumbnail size in predicting handedness. A more accurate test to determine handedness was recently described by Syed.<sup>1</sup>He found that if a person pairs the second and third fingers and also the fourth and fifth fingers of both hands and then stretches these paired fingers away from each other as far as possible, the interdigital space between these two pairswill be larger in the left hand than in the right hand in a right-handed person and vice versa. The reliability of this method was investigated and compared to the thumbnail size test in 85 persons ranging in age from 7 to 57 years. Persons who had sustained trauma to their hands or were neurologically impaired were excluded, as were children under 7 years of age, because they had great difficulty
Commentaire de travail de J. H. Kim et al., pp. 190
Journal: Endoscopy (2011)

See also: Is minimal change esophagitis really part of the spectrum of endoscopic findings of gastroesophageal reflux disease? A prospective, multicenter studyEndoscopy 2011; 43(03): 190-195DOI: 10.1055/s-0030-1256101
Novobiocin Jaundice
Authors: Rody P. Cox, E. L. Foltz, Samuel Raymond, Richard Drewyer
Journal: New England Journal of Medicine (1959)

THE clinical use of novobiocin is increasing because of its effectiveness in the treatment of staphylococcal infections. Toxic reactions1 , 2 include mild diarrhea (37 per cent), skin rashes (8.9 per cent), fever (2 per cent), eosinophilia (1.47 per cent), gastrointestinal irritation with nausea (1.3 per cent) and leukopenia (0.6 per cent).During novobiocin treatment yellowish discoloration of the skin and sclerae occasionally appears (0.6 per cent).2 The pigment is believed to be a degradation product of the drug and not related to hepatic dysfunction.1 2 3 However, chronic toxicity studies on dogs and rats demonstrated that hepatic degeneration may occur.4 The only clinical . . .
Correction to: Durable Clinical Effectiveness With Paclitaxel-Eluting Stents in the Femoropopliteal Artery 5-Year Results of the Zilver PTX Randomized Trial
Journal: Circulation (2019)

When high-resolution files were requested during production, an incorrect version of Figure 1 was mistakenly provided.Subsequently, the published version of the flow chart in Figure 1 contained incorrect numbers.The authors now provide the corrected version of Figure 1.Additionally, the following sentence from the 'Safety' section is incorrect: "The 5-year all-cause mortality rate was 13.6% (10.2% for the primary DES group and 16.9% for the PTA group, P=0.03), and no deaths were adjudicated as procedure or device related."The authors regret that the numbers for the two groups were inadvertently reversed.The sentence should read:"The 5-year all-cause mortality rate was 13.6% (16.9% for the primary DES group and 10.2% for the PTA group, P=0.03), and no deaths were adjudicated as procedure or device related.
Incidence rates
Authors: P. Sedgwick
Journal: BMJ (2012)

<h3>Abstract</h3> <h3>Objectives</h3> Norway and Sweden have similar populations and health care systems, but different reactions to the COVID-19 pandemic. Norway closed educational institutions, and banned sports and cultural activities; Sweden kept most institutions and training facilities open. We aimed to compare peoples’ attitudes towards authorities and control measures, and effects on life in Norway and Sweden. <h3>Design</h3> Anonymous web-based surveys for individuals age 15 or older distributed through Facebook using the snowball method. <h3>Setting</h3> Norway and Sweden, mid-March to mid-April, 2020. <h3>Participants</h3> 3,508 individuals participated in the survey (Norway 3000; Sweden 508). 79% were women, the majority were 30-49 years (Norway 60%; Sweden 47%), and about 45% of the participants in both countries had more than four years of higher education. <h3>Outcome measures</h3> Perceived threat of the pandemic, views on infection control measures, and impact on daily life. We performed descriptive analyses of the responses and compared the two countries. <h3>Results</h3> Participants had high trust in the health services, but differed in the degree of trust in their government (High trust in Norway 17%; Sweden 37%). More Norwegians than Swedes agreed that school closure was a good measure (Norway 66%; Sweden 18%), that countries with open schools were irresponsible (Norway 65%; Sweden 23%), and that the threat from repercussions of the mitigation measures were large or very large (Norway 71%; Sweden 56%). Both countries had a high compliance with infection preventive measures (&gt; 98%). Many lived a more sedentary life (Norway 69%; Sweden 50%) and ate more (Norway 44%; Sweden 33%) during the pandemic. <h3>Conclusion</h3> Sweden had more trust in the authorities, while Norwegians reported a more negative lifestyle during the pandemic. The level of trust in the health care system and self-reported compliance with preventive measures was high in both countries despite the differences in infection control measures. <h3>Strengths and limitations of this study</h3> This study compares people’s attitudes to the handling of the COVID-19 pandemic in Norway and Sweden, two very similar countries with different strategies The study provides a situation assessment of the attitudes and self-reported compliance to infection preventive measures taken by Norwegian and Swedish authorities The study participants were recruited to answer the survey through Facebook and their views may not be generalizable to the whole population in Norway and Sweden The surveys were distributed three weeks apart in time in the two countries. The situation was stable during that time-period in both countries.
Medical Schools in Canada
Journal: JAMA (1984)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Chemistry, Biological Activity, and Uses of Formamidine Pesticides
Authors: R. M. Hollingworth
Journal: Environmental Health Perspectives (1976)

The formamidines, a relatively new group of acaricide-insecticides, are novel both in their range of biological activities and in their mode of action, which is presently unknown. This paper is a review of the historical development, properties, structures, uses, and chemistry of this group of pesticides, with particular emphasis on chlordimeform (Galecron or Fundal), N'-4-chloro-o-tolyl-N,N-dimethylformamidine, and amitraz, 1,3=di-(2,4-dimethylphenylimino)-2-methyl-2-azapropane. Their biological activity and uses are defined by their toxicity to spider mites, ticks, and certain insects, and they are particularly effective against juvenile and resistant forms of these organisms. A significant, but poorly understood feature of their field effectiveness is their breadth of toxic action which includes direct lethality, excitant-repellant behavioral effects, and chemosterilization. They are generally of low hazard for nontarget species with the significant exception of predaceous mites. Several aspects of the chemistry of these compounds are considered, including structure--activity relations, synthetic pathways, isomerism and configuration, and their chemical and environmental stability. A significant feature of the metabolism and toxicity of these agents is the possible activation of chlordimeform by N-demethylation in vivo. Strong evidence for this has been presented with the cattle tick, but recent results discussed here suggest that in other species, i.e., mice, German cockroaches or black cutworm eggs, N-demethylation is neither a strong activation nor a detoxication reaction.
PARIS
Journal: JAMA (1952)

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Human Dendritic Cells Stimulated with a Novel Peanut Protein Express High Levels of RALDH2 and Induce RA-Sensitive Genes in Naïve T Cells
Authors: Bert Ruiter, Galina Grishina, Stans den Hartog Jager, Edward F. Knol, Peggy Ozias-Akins, Hugh A. Sampson, Wayne G. Shreffler
Journal: Journal of Allergy and Clinical Immunology (2013)
EMIL KRAEPELIN (1856-1926) PSYCHIATRIC NOSOGRAPHER
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal