tbuckley/cabot-search huggingface dataset:
Book Review Thomson and Miles' Manual of Surgery . By Alexander Miles, M.D., LL.D., F.R.C.S. Ed. and D. P. D. Wilkie, M.D., F.R.C.S. Ed. and Eng. Volume first; General Surgery. Eighth Edition. 556 pages plus index, with 176 Illustrations. Humphrey Milford. Oxford University Press, London and Edinburgh. Price $3.80.
Journal: New England Journal of Medicine (1931)
Epidural spinal cord compression: A single institution's retrospective experience
Authors: Marc C. Chamberlain, Patty A. Kormanik
Journal: Neuro-Oncology (1999)

Epidural spinal cord compression (ESCC) is a common metastatic complication occurring in5% of patients with cancer.We sought to determine retrospectively the frequency of multiple sites of ESCC at presentation and the risk of recurrence of ESCC.Of the cancer patients seen by the University of California San Diego's Neuro-Oncology Service between August 1986 and January 1997, 108 developed ESCC that was documented both clinically and by MRI of the spine.In 77 patients (71%), a single site of ESCC was seen; 31 patients (29%) had multiple sites of ESCC.All sites of ESCC were irradiated.In 7% of patients with single-site ESCC and in 9% of patients with multiple-site ESCC, the disease recurred.Length of survival was similar for patients with single-or multiple-site ESCC (median, 4.5 months) versus patients with recurrent ESCC (median, 7 months).An MRI of the entire spine in patients with suspected ESCC demonstrated multiple sites of ESCC in nearly one-third of patients.In 8% of patients with ESCC, symptomatic
Fleeting Wisdom
Authors: Robert Auerbach
Journal: JAMA (1987)

<h3>To the Editor.—</h3> I offer a comment regarding the article entitled "Fleeting Wisdom."1 The implication of the article was that no treatment should have been instituted for a basal cell carcinoma in a 106-year-old man who died of medical complications following surgical removal. As a practicing dermatologist, I think a better approach to this patient would have been outpatient biopsy followed by radiation therapy. Outpatient surgery with healing by secondary intention, while giving good results, would have been a distant second choice. The error was not in treating, but in bringing him into the hospital for over-elaborate treatment.
Evolution of the diagnosis of acute myocardial infarction JoAnne M. Foody, Deron H. Galusha, Jennifer M. Lewis, Dale R. Burwen, Martha J. Radford, Harlan M. Krumholz. Qualidigm, Middletown, CT, Health Care Financing Administration, Baltimore, MD
Journal: Journal of the American College of Cardiology (2001)
A phase III study of induction therapy with gemcitabine + carboplatin (GC) followed by either delayed vs. immediate second-line therapy with docetaxel (D) in advanced non-small cell lung cancer (NSCLC)
Authors: J. H. Schiller, P. Fidias, S. R. Dakhil, A. P. Lyss, J. A. Figueroa, J. K. Choksi, D. M. Loesch, L. P. Bloss, Z. Ye, C. K. Obasaju
Journal: Journal of Clinical Oncology (2005)

7142 Background: GC is one of several active platinum-based regimens in NSCLC. Enhancing this effect with follow-on therapy, however, is less clear. The efficacy of D in the second-line setting at the time of progression is well established. Nevertheless, its role as sequential chemotherapy following a response to a platinum regimen is unclear. Treatment benefit, quality of life, and overall survival all factor into this decision. The purpose of this trial was to test the value of immediate sequential D compared with standard therapy of second-line D at the time of progression following initial therapy with GC. This abstract reports the results of the initial GC; data on immediate vs delayed D strategies will be determined by overall survival and is ongoing. Methods: Pts with Stage IIIB or IV NSCLC were enrolled (including pts with recurrent disease after primary treatment). G 1000mg/m2 was administered on day 1,8 followed by C at AUC 5.0 on day 1. After 4 cycles, non-progressers were then randomized to immediate D (75mg/m2 administered on day 1 every 3 wks) or delayed D (pts were observed until first evidence of PD). Results: 356 pts (M 61%; F 39%) have received GC of a planned 550. Median age: 65.2 yrs; Performance status 0:1:2 = 43%: 44%:13%. Clinical Stage IIIB: IV = 14%: 83%. To date, 145 have been randomized between immediate or delayed D. Primary Grade 3/4 events during GC out of 1076 cycles were neutropenia (8.1%), thrombocytopenia (7.8%), febrile neutropenia (0.5%) and anemia (3.3%); Primary nonhem Grade 3/4 events included nausea & vomiting (2%), dyspnea (1.7%) Pneumonia, rash, and alopecia occurred ≤ 0.1%. The clinical benefit rate to induction GC in 179 evaluable pts is 86% (CR 2.2%; PR 35.8%, SD= 48.6%), with a response rate of 38% (CR+PR) (95% CI: 30.9%–45.5%), PD=13.4%. Conclusions: Currently 423 pts (75% of targeted accrual) have been enrolled, this preliminary data supports the efficacy and tolerability of first-line GC in advanced NSCLC, once accrual and event endpoints have been attained, further information will be available. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Eli Lilly Eli Lilly, Genentech AstraZeneca, Taiho Millenium EMD Eli Lilly Eli Lilly, GlaxoSmithKline, Lilly Oncology Taiho, Member of the Speakers Bureau of Eli Lilly and Company Eli Lilly, Lilly Underwriters Trial 02099 for me in breast cancer, Participation in Clincial Trial with Eli-Lilly and Company
Small-bowel endoscopy
Authors: K. Mönkemüller, C. Olano, L. Fry, P. Malfertheiner
Journal: Endoscopy (2008)

Double-balloon enteroscopy (DBE) has been a major breakthrough in small-bowel imaging and therapy [2] [3] [4] [5] [6]. Until recently the major types of balloon enteroscopes available for investigation of the small bowel were the diagnostic and therapeutic Fujinon® enteroscopes [2] [3] [4] [5] [6]. Tsujikawa from Japan developed and presented the first large feasibility study using the single-balloon enteroscope (Olympus®, Japan) [6]. A total of 78 procedures were performed in 41 patients, with standard indications such as obscure gastrointestinal bleeding, diarrhea, and Crohn’s disease. The mean procedure time was 62.8 ± 20.2 minutes and 70.4 ± 19.3 minutes for the oral and anal routes, respectively. Among 24 patients in whom total enteroscopy was attempted, the entire small intestine was explored in six (25 %) [1]. The authors concluded that single-balloon enteroscopy (SBE) is not only easy to perform, due to the single balloon, but it can also safely lead to examination of the entire small intestine. Therefore, SBE is a useful diagnostic and therapeutic tool in addition to DBE for investigating suspected small-bowel disease.
Abstract P261: HIV-positive Individuals With Undetectable Viral Loads Have suPAR Levels Comparable to HIV-negative Individuals
Authors: Matthew L Topel, Salim H Hayek, Shikha Wadhwani, Caitlin Moran, Dustin A Staloch, Changli Wei, Jochen Reiser, Ighovwerha Ofotokun, Arshed A Quyyumi
Journal: Circulation (2017)

Introduction: Individuals with poorly-controlled HIV have high levels of plasma soluble urokinase plasminogen activator receptor (suPAR), a marker of immune activation associated with all-cause mortality, incident myocardial infarction and HIV-associated nephropathy in HIV-positive individuals. Data is conflicting regarding the effect of viral suppression on suPAR levels in HIV-positive individuals, or how these levels compare to individuals without HIV. Hypothesis: HIV-positive individuals with undetectable viral loads (VLs) will have similar levels of suPAR compared to individuals without HIV. Methods: Plasma suPAR was measured by ELISA in 273HIV-positive (70% Black [n=167], age 42 ± 8 years, 86% female [n=240], 56% detectable viral load [n=150]) and 276 HIV-negative (63% Black [n=169], age 40 ± 9 years, 96% female [n=265]) outpatients. Demographics, medical history and laboratory samples were collected. Results: Compared to HIV-negative individuals, HIV-positive subjects were older (p=0.01), less likely to be female (p&lt;0.001), had lower body mass index (28 ± 7 vs. 30 ± 8 kg/m 2 , p&lt;0.001) and worse renal function (eGFR 92 ± 19 vs. 97 ± 20 mL/min/1.73 m 2 , p=0.004). Median suPAR level was similar for HIV-negative and HIV-positive subjects with undetectable VLs (2436 [1908, 3380] vs. 2667 [1966, 4034] pg/mL, p=0.256), and both were significantly lower compared to HIV-positive subjects with detectable VLs (4252 [3099, 5369] pg/mL, p&lt;0.001). Within HIV-positive subjects, a detectable viral load was an independent predictor for high suPAR (OR 2.37 [95% CI 1.07-5.25], p=0.03) after controlling for age, race, sex, body mass, smoking history, hypertension, diabetes, eGFR and CD4+ count. Conclusions: In conclusion,HIV-positive individuals with undetectable VLs have similar levels of suPAR compared to those without HIV. Lower suPAR levels may account for the lower incidence of cardiovascular events and HIV nephropathy in patients with well-controlled HIV.
Authors’ Names Reversed
Authors: Willemijn Jansen, Rik Ossenkoppele, Pieter Visser
Journal: JAMA (2015)

positivity between participants with SCI and those who were cognitively normal.Second, they indicate that the absence of correction for education in the analysis presented in Figure 2 could have biased our findings because of differences in educational level between participants with normal cognition and SCI.We have repeated the analysis for the data shown in Figure 2 with correction for education and found no statistically significant difference in amyloid positivity between participants with normal cognition and patients with SCI (mean difference, -4% [95% CI, -13% to 5%]; P = .35).Third, it is suggested that our definition of SCI was limited and that the normal cognition group may have included participants with SCI.The studies included in our metaanalysis adopted different inclusion criteria for SCI.We defined SCI as referral to a memory clinic in the absence of objective impairment because this could be implemented reliably across studies.This definition also seems compatible with a definition of SCI that is supposed to be more specific for AD. 2 However, we cannot exclude the possibility that the normal cognition group included participants with SCI according to other definitions.Yet in additional analyses, we selected 6 studies from our meta-analysis that explicitly excluded participants with cognitive complaints from the normal cognition group and still found no statistically significant difference in amyloid positivity between the participants with normal cognition (n = 214) and patients with SCI (n = 413; mean difference, 1% [95% CI, -5% to 7%]; P = .77).We agree with Wagner and Jessen that more research is needed on the standardization of the SCI construct.Future studies combining biomarkers and long-term neuropsychological and clinical follow-up need to establish whether there is a specific definition of SCI that is associated with amyloid positivity and that is predictive for AD.
Charles Oliver Probst: A Pioneer Public Health Administrator in Ohio
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Note of Appreciation
Authors: Marloes M. Gerrits, Patricia van Oppen, Harm W. van Marwijk, Henriëtte van der Horst, Brenda W. Penninx, John S. Ogrodniczuk, Anthony S. Joyce, William E. Piper, Louisa G. Sylvia, Amy T. Peters, Thilo Deckersbach, Andrew A. Nierenberg, Giovanni A. Fava, Sarah E. Romans, David Kreindler, Eriola Asllani, Gillian Einstein, Sheila Laredo, Anthony Levitt, Kathryn Morgan, Michele Petrovic, Brenda Toner, Donna E. Stewart, Søren Dinesen Østergaard, Georgios Petrides, Peter Thisted Dinesen, Søren Skadhede, Per Bech, Povl Munk-Jørgensen, Jimmi Nielsen, Fiammetta Cosci, Giovanni A. Fava, Jenny Rosendahl, Katharina Tigges-Limmer, Jan Gummert, Ralf Dziewas, Johannes Maximilian Albes, Bernhard Strauss, Satz Mengensatzproduktion, Druck Reinhardt Druck Basel, Druck Reinhardt Druck Basel
Journal: Psychotherapy and Psychosomatics (2012)
RELATION OF GOUT AND URIC ACID.
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
National Cancer Institute Monograph 29, December 1968 “Cell Cultures for Virus Vaccine Production”
Journal: JNCI Journal of the National Cancer Institute (1968)

National Cancer Institute Monograph 29, December 1968 “Cell Cultures for Virus Vaccine Production” Get access JNCI: Journal of the National Cancer Institute, Volume 41, Issue 6, December 1968, Page 1495, https://doi.org/10.1093/jnci/41.6.1495 Published: 01 December 1968
Breast-feeding
Authors: Phyllis Dahl
Journal: JAMA (1983)

<h3>To the Editor.—</h3> I would like to respond to some of the comments in Dr Katherine Christoffel's review of<i>The Womanly Art of Breastfeeding</i>(1982;248:993). In her review, Dr Christoffel criticized the book's tone, which she states may limit its usefulness to many mothers. While it may be true that La Leche League International (LLLI) has "evolved what is almost a subcultural life-style in which family organization and relations center around breast-feeding and the no longer typical nuclear family structure of breadwinner father and homemaker mother," this does not detract from the applicability and the usefulness of the breastfeeding information contained within. During the 25 years of LLLI's existence, many rapid changes have occurred within our society. Nevertheless, LLLI remains an advocate for meeting the needs of the human baby for nurturance and a stable identity figure. La Leche League International is oriented for those mothers who choose to breast-feed
Obesity
Authors: Anthony N. Fabricatore, Thomas A. Wadden
Journal: Annual Review of Clinical Psychology (2006)

The prevalence of obesity is growing at an alarming rate. Thus, investigation into the etiology, comorbidities, and treatment of obesity has burgeoned in recent years. While novel therapies--both behavioral and pharmacological--have been developed and tested, the mean weight losses achieved with nonsurgical approaches have remained virtually unchanged over the past 20 years. Fortunately, the modest weight losses achieved with these methods are associated with significant reductions in obesity-related health problems. With the most intensive available treatment (i.e., bariatric surgery), many patients achieve remission of comorbid conditions. This article defines obesity and provides an overview of the disease conditions associated with excess weight. Treatment options and outcomes are reviewed and future steps-including efforts to prevent obesity--are identified. Finally, the literature on the relationship between obesity and depression is examined.
Response to Comment on Young-Hyman et al. Psychosocial Care for People With Diabetes: A Position Statement of the American Diabetes Association. Diabetes Care 2016;39:2126–2140
Authors: Deborah Young-Hyman, Mary de Groot, Felicia Hill-Briggs, Jeffrey S. Gonzalez, Korey Hood, Mark Peyrot
Journal: Diabetes Care (2018)
Cardiomyopathy associated with the smoking of crystal methamphetamine
Authors: R. Hong
Journal: JAMA (1991)

The smoking of crystal methamphetamine, or "ice," is a growing drug abuse problem in the United States. The toxic effects of methamphetamine smoking have not been well described. We describe two patients with cardiovascular toxic effects associated with the smoking of crystal methamphetamine. In our first patient, the use of smokable methamphetamine was associated with the subsequent development of pulmonary edema and a dilated cardiomyopathy. In our second patient, the smoking of crystal methamphetamine likely produced diffuse vasospasm that resulted in acute myocardial infarction, cardiogenic shock, and death. The recognition of potentially lethal cardiac complications associated with the smoking of crystal methamphetamine is of extreme significance and should be emphasized to potential abusers of this drug. (<i>JAMA</i>. 1991;265:1152-1154)
Phase I Study of Rituximab, Lenalidomide, and Ibrutinib in Previously Untreated Follicular Lymphoma (Alliance 051103)
Authors: Chaitra S. Ujjani, Sin-Ho Jung, Brandelyn Pitcher, Peter Martin, Steven I. Park, Kristie A. Blum, Sonali M. Smith, Myron S. Czuczman, Matthew S. Davids, John P. Leonard, Bruce D. Cheson
Journal: Blood (2015)
Health of the homeless
Authors: None The Lancet
Journal: The Lancet (2014)

Having a home is a basic human need. However, in any one night in Europe and the USA alone, around 1 million people are classified as homeless. This week The Lancet publishes a new two-paper Series on homelessness and health, led by John Geddes, Seena Fazel, and colleagues. People become homeless through a complex interaction between individual and structural factors (eg, poverty, health, substance misuse, violence, and unemployment). Homelessness can be a long-term state or a temporary transitional period related to circumstances such as domestic violence.
Failure of corticosteroid to potentiate sympathomimetic pressor response during shock
Authors: H. Shubin
Journal: JAMA (1966)

Corticosteroids administered in an emergency neither increase arterial pressure nor enhance the pressor response to levarterenol (norepinephrine) in normotensive human subjects with normal adrenal function.<sup>1,2</sup>In rats, dogs, and humans<sup>3</sup>who have adrenocortical insufficiency, however, corticosteroid hormones clearly increase the pressor response to sympathomimetic amines. These facts have led to the presumption of adrenocortical insufficiency in cases of circulatory shock in which responsiveness to vasopressor amines is diminished. Yet there is neither experimental nor clinical confirmation of adrenocortical insufficiency in shock following hemorrhage or shock complicating infection; to the contrary, the output of adrenocortical hormone is tripled. Nevertheless, the clinical impression persists that during shock corticosteroids enhance the pressor response to catecholamines. <h3>Clinical Material.—</h3> Nine patients, four men and five women, ranging from 41 to 76 years of age, hospitalized in the Los Angeles County General Hospital, were the subjects of investigation. Clinical features of shock were documented
Information 'leaking' about CLIA-implementing regulations to be published early in 1992
Authors: C. Marwick
Journal: JAMA (1991)

PROPOSED REGULATIONS to implement the Clinical Laboratory Improvement Amendments (CLIA) of 1988 are nearing completion. Publication is expected early in 1992, although even then there may be some provision for comments. The 1988 amendments require that all clinical laboratories meet quality standards and be certified by the federal government. Even before they are published, however, the impact of the amendments soon will be brought home to physicians and others who operate clinical laboratories. This initial impact will be in the form of a detailed questionnaire from the Health Care Financing Administration (HCFA), the object of which is to give HCFA officials a better idea of the regulatory task that lies ahead of them. <h3>Complex Questionnaire</h3> The questionnaire is being sent to some 640 000 addresses, including physicians' office laboratories. The mailing even includes those who provide sidewalk cholesterol screening tests. Some who have seen the questionnaire estimate that it will
Obituaries
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dermabrasion and Isotretinoin
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal