tbuckley/cabot-search huggingface dataset:
Changes in working status of patients following coronary bypass surgery
Authors: G. K. Barnes
Journal: JAMA (1977)

Coronary artery bypass surgery has gained a major role in the management of ischemic heart disease. Relief of symptoms is often the primary goal for these surgical procedures while other effects relating to rehabilitation of such patients have been neglected. To determine change in work status as a result of operation, job status and hours worked before and after surgery were analyzed in 350 patients who had coronary artery bypass grafting procedures. Overall, there was no improvement in return to work or hours worked after surgery. Hours worked before surgery, relief of symptoms, severity of disease, number of bypass grafts placed, and level of education all related substantially to a change in work capacity. It appears that if the potential for enhanced productivity is to be realized, rehabilitative measures must be intensified following coronary artery surgery. (<i>JAMA</i>238:1259-1262, 1977)
THE FOURTH OF JULY CELEBRATION.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
P1.01-33 Randomized Phase 2 Study Comparing CBDCA+PTX+BEV and CDDP+PEM+BEV in Treatment-Naïve Advanced Non-Sq NSCLC (CLEAR study)
Authors: T. Harada, H. Udagawa, E. Sugiyama, S. Atagi, R. Koyama, S. Watanabe, Y. Nakamura, D. Harada, O. Hataji, F. Tanaka, A. Niimi, H. Kida, M. Satouchi, A. Inoue, Y. Urata, Y. Yamane, K. Yoh, H. Yoshioka, T. Yamanaka, K. Goto
Journal: Journal of Thoracic Oncology (2018)
INSANE ARTISTS.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Colposcopy and Colpomicroscopy Meeting
Journal: JNCI Journal of the National Cancer Institute (1968)

Colposcopy and Colpomicroscopy Meeting Get access JNCI: Journal of the National Cancer Institute, Volume 41, Issue 4, October 1968, Page 1037, https://doi.org/10.1093/jnci/41.4.1037 Published: 01 October 1968
Association between Drinking Water Disinfection and Somatic Parameters at Birth
Authors: Stefano Kanitz, Yaurana Franco, Vittoriana Patrone, Marta Caltabellotta, Enrico Raffo, Cristina Riggi, Daniela Timitilli, Giambattista Ravera
Journal: Environmental Health Perspectives (1996)

We conducted an epidemiological study in Liguria, Italy, on the association between somatic parameters at birth and drinking water disinfection with chlorine dioxide and/or sodium hypochlorite. Over 2 years (1988-1989), 676 births at two public hospitals, one in Genoa (548 cases) and another in Chiavari (128 cases) were examined and data regarding both mother and child were obtained from hospital records. Results indicate a higher frequency of small body length (< or = 49.5 cm) and small cranial circumference (< or = 35 cm) in infants born to mothers who drank water treated with chlorine compounds. In particular, the statistical analysis (by simultaneous variance analysis and Scheffé test) indicated that there may be an association between infants with smaller body length and mothers who drank water treated with chlorine dioxide [adjusted odds radio (OR) = 2.0; 95% CI = 1.2-3.3] or sodium hypoclorite (adjusted OR = 2.3; 95% CI = 1.3-4.2) and between infants with smaller cranial circumference and mothers who drank water treated with chlorine dioxide (adjusted OR = 2.2; 95% CI = 1.4-3.9) or sodium hypochlorite (adjusted OR = 3.5; 95% CI = 2.1-8.5). The presence of neonatal jaundice is almost twice as likely (adjusted OR = 1.7; 95% CI = 1.1-3.1) in infants whose mothers drank water treated with chlorine dioxide.
Steroid Anaesthesia
Authors: A. H. Galley
Journal: BMJ (1956)

<h3>Abstract</h3> Glioblastoma (GBM) is the most prevalent and aggressive adult primary cancer in the central nervous system (CNS). Therapeutic approaches for glioblastoma are under intense investigation, such as the emerging immunotherapy, but so far only marginal progress has been made due to the heterogeneity and highly invasive nature of glioblastoma. Here, we propose an alternative approach to tackle GBM through reprogramming proliferative GBM cells into non-proliferative neurons. We report efficient neuronal conversion from human GBM cells by overexpressing single neural transcription factor Neurogenic differentiation 1 (NeuroD1), Neurogenin-2 (Neurog2) or Achaete-scute homolog 1 (Ascl1). Subtype characterization reveals that the majority of Neurog2- and NeuroD1-converted neurons are glutamatergic, while Ascl1 favors GABAergic neuron generation. The GBM cell-converted neurons not only express pan-neuronal markers, such as NeuN and MAP2, but also exhibit neuron-specific electrophysiological activities. We further conducted transcriptome analyses to investigate the underlying cell conversion mechanism. Our RNA-seq analyses discover that neuronal genes are activated among glioma cells after overexpression of neural transcription factors, and different signaling pathways are activated by different neural transcription factors. Importantly, the neuronal conversion of GBM cells is accompanied by significant inhibition of GBM cell proliferation in both <i>in vitro</i> and <i>in vivo</i> models. Therefore, these results suggest that GBM cells can be reprogrammed into different subtypes of neurons, leading to a potential alternative approach to treat brain tumor. <h3>Significance</h3> Converting dividing glioblastoma cells into non-dividing neurons may provide an innovative therapeutic approach to treat glioblastoma. <h3>Highlights</h3> Efficient neuronal conversion of human glioblastoma cells achieved by overexpression of neural transcription factors Neurog2- and NeuroD1-converted neurons are mostly glutamatergic, while Ascl1-converted neurons are mainly GABAergic Transcriptome analyses reveal the activation of neuronal genes after overexpression of neural transcription factors in glioblastoma cells Inhibition of cell proliferation during glioblastoma cell conversion both <i>in vitro</i> and <i>in vivo</i>
The Principles and Practice of Hydrotherapy, a Guide to the Application of Water in Disease, for Students and Practitioners of Medicine.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Neomycin-resistant staphylococci in outpatients
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reducing rates of diagnostic imaging
Authors: J. O. Greenberg
Journal: JAMA (1997)

<h3>To the Editor.</h3> —I read the article by Dr Bree and colleagues<sup>1</sup>with great interest. The authors of this randomized controlled trial concluded that an inpatient radiology consultation service did not reduce resource use. Physicians in the control group ordered about the same number and types of tests as those in the intervention group, despite radiological guidance for the intervention group. This suggests that the physicians on these medical services are knowledgeable about this subject. The authors of this article suggested that it might be more appropriate to study the outpatient setting. In their last paragraph, the authors state that "it has already been shown that physicians may overutilize imaging tests when engaged in in-office self-referral," and cite an article by Hillman et al.<sup>2</sup>In November 1992, the United Mine Workers of America refused to reimburse nonradiologists for interpretation of imaging studies based on another study by Hillman
Clinical Observations on the Treatment of Fractures by the Immovable Apparatus
Authors: J. S. Gamgee
Journal: BMJ (1857)

pregnancy.She was tapped as for ovarian dropsy; unhappily it was an hepatic cyst, not united to the abdominal parietes, some of the fluid escaped into peritoneum, succeeded by death in eighteeen houirs.Insufficient stress hadl been laid upon the sufferer's statemeut that the swelling-commiienced at epigas- trium.It is probable.that if the nature of the tumour had appeared doubtful, anid the openingi into cyst had been cautiously effected throughl the intervention of potassa fusa, the patient's life wouild have been spare(l.This unfortunate instance may be serviceable as a warning and as a hlint in Dr. Markhams interesting case.
American Surgeon, Baltimore
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Changing trends in peptic ulcer disease: the rise of NSAID-induced and fall of H pylori-induced ulcers
Authors: C. O. Musumba, D. Van Eker, A. Jorgensen, M. Pritchard, M. Pirmohamed
Journal: Gut (2011)

<h3>Introduction</h3> Non-steroidal anti-inflammatory drugs (NSAIDs) and <i>Helicobacter pylori</i> are the main causes of peptic ulcer disease (PUD). Data from the UK from 1997 to 2005 indicated that the aetiology is slowly changing as the prevalence of <i>H pylori</i> and use of non-aspirin NSAIDs (NANSAIDs) has been decreasing while the use of low-dose aspirin (LDA; ≤325 mg/day) has been increasing. <h3>Methods</h3> In order to investigate these changing trends, subjects who presented with endoscopically confirmed PUD at Royal Liverpool Hospital between July 2005 and June 2010 were identified from the endoscopy database and recruited either prospectively or retrospectively. Recruits were interviewed using a structured questionnaire and GPs were contacted to capture data missing from case-notes. Patients were categorised as either NSAID users (those on NSAIDs within 2 weeks) or non-users (those not on NSAIDs within 3 months of endoscopy). Upper GI bleeding (UGIB) was defined as haematemesis, melaena or anaemia (haemoglobin drop ≤2g/dl) and/or endoscopic stigmata of recent bleeding. <i>H pylori</i> status was determined by the rapid urease test and/or histology, or serology (IgG, ELISA) where these were negative or not done. <h3>Results</h3> Of the 389 patients enrolled, 220 (57%) were using NSAIDs and 169 (43%) were non-users. 29% of the whole cohort were taking LDA alone. 57% of the patients were 65 years or above, comprising 66% of NSAID users and 41% of non-users, with mean ages of 67 and 60 (SD 13.5 vs16) years, respectively. The mean age of those using LDA alone was 70 (SD 10.6) years. <i>H pylori</i> was positive in 41% of ulcers (46% DU, 33% GU). Amongst NSAID users, 51% were on LDA, 30% on NANSAIDS, 15% on both LDA and NANSAIDs and 4% on high dose aspirin. NSAID users had more GU (59% vs. 45%, p=0.006), fewer DU (31% vs 48%, p=0.001) and were less likely to be <i>H pylori</i> positive (34% vs. 49%, p=0.005); there was no difference in gender (% males 50 vs. 56, p=0.318) or prevalence of UGIB (22% vs 20%, p=0.697) between the two groups. Compared to NANSAID users, LDA users were more likely to be <i>H pylori</i> positive (43% vs. 23%, p=0.003) with a similar prevalence of UGIB (21% vs. 20%, p=0.987). 22% of patients with PUD were neither using NSAIDs nor <i>H pylori</i> positive. <h3>Conclusion</h3> NSAIDs, particularly LDA, were the commonest cause of PUD in this cohort, especially in those over 65 years. Our findings are compatible with the steady decline in the prevalence of <i>H pylori</i>-positive PUD and increase in non-NSAID non-<i>H pylori</i> PUD over recent years. LDA users were older and more likely to be <i>H pylori</i> positive compared to those using NANSAIDs; the significance of this in terms of ulcer pathogenesis needs further study.
The effects of pioglitazone treatment on pancreatic cancer-related insulin resistance.
Authors: Jennifer Stern, Yull Edwin Arriaga, Arjun Gupta, Udit N. Verma, Sirisha Karri, Samira K. Syed, Leticia Khosama, John C. Mansour, Philipp Scherer, Muhammad Shaalan Beg
Journal: Journal of Clinical Oncology (2017)

e15752 Background: Insulin resistance (IR) in pancreatic cancer (PC) patients is associated with cachexia and poor outcome. Pioglitazone (PIO) improves insulin sensitivity via activation of peroxisome proliferator-activated receptor (PPAR gamma). Effects of PIO on insulin sensitivity, glucose homeostasis, and circulating adipokine levels in PC have not been examined. Methods: Patients with metastatic PC were administered PIO 45mg/day orally for 8 weeks concurrent with chemotherapy. Patients with known DM at enrollment were identified Fasting plasma was collected at baseline, weeks 2, 4, 6, 8 of pioglitazone treatment and at 2 weeks-post treatment. The primary objective was to describe changes in indicators of IR, including glucoregulatory hormone levels, glucose tolerance, and inflammatory cytokines. Results: Fourteen patients (age 64y), with a mean BMI of 28 were enrolled. Mean adiponectin increased from baseline to week 8 of treatment (14.2± 3.3 and 46.9±11.4µg/ml, respectively, P ≤ 0.01), and returned to baseline levels at 2 weeks post-treatment (15.1±1.9 µg/ml). Markers of IR (serum glucose, insulin, glucagon, and response to an oral glucose bolus) did not correlate with tumor size, inflammatory cytokine levels, GM-CSF, or CA19-9. A dichotomous response to PIO treatment was observed between non-diabetic and T2DM patients. Fasting insulin increased 70.6±31.3% from baseline to treatment week 8 in patients with T2DM. In contrast, treatment of non-diabetic patients decreased fasting insulin by 40.2±6.3%, demonstrating a significant, P ≤ 0.01, difference in treatment response between PC patients with or without T2DM. Conclusions: We have demonstrated that PC patients respond to 8 weeks of PIO treatment with a significant rise in the insulin sensitizing adipokine, Adiponectin, with a complete wash-out after 2 weeks of cessation. PIO results in opposing fasting insulin responses in non-diabetic and DM patients suggests that diabetes status plays a significant role in the glucoregulatory effects of PIO treatment in PC patients. Clinical trial information Clinical trial information: NCT01838317.
A Physician’s Personal Hobbies and Prescriptions
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A phase I pharmacokinetic (PK) and pharmacodynamic (PD) study of OGX-011, a 2'methoxyethyl phosphorothioate antisense to <i>clusterin</i>, in patients with prostate cancer prior to radical prostatectomy
Authors: K. N. Chi, E. Eisenhauer, L. Fazli, E. C. Jones, J. Powers, D. Ayers, S. L. Goldenberg, M. E. Gleave
Journal: Journal of Clinical Oncology (2004)

3033
A C----T substitution at nt--101 in a conserved DNA sequence of the promotor region of the beta-globin gene is associated with “silent” beta-thalassemia
Authors: JM Gonzalez-Redondo, TA Stoming, A Kutlar, F Kutlar, KD Lanclos, EF Howard, YJ Fei, M Aksoy, C Altay, A Gurgey
Journal: Blood (1989)
Abstract 9: The Japan Environment and Children’s Study and Kawasaki disease
Authors: Shuichi Ito, Kiwako Yamamoto, Kimie Ishizuka, Hisako Komuro, Hidetoshi Mezawa, Hiroshi Masuda, Jun Abe, Masashi Ono, Yukihiro Ohya
Journal: Circulation (2015)

Background: The Japan Environment and Children’s Study (JECS) is a nation-wide birth cohort study involving 100,000 parent-child pairs that was conducted by the Japanese Ministry of the Environment. This study was started in 2011 to evaluate the effect of various environmental factors on children’s health and development. Health outcomes and exposure measurements will continue until the participating children become 13 years old. Method: Exposure to environmental factors was assessed by chemical analyses of bio-specimens (blood, cord blood, urine, breast milk, and hair), household environmental measurements, and computational simulations using monitoring data, as well as questionnaires. The JECS’s priority outcomes include reproduction/pregnancy complications, congenital anomalies, neuropsychiatric disorders, immune system disorders, including Kawasaki disease (KD), and metabolic/endocrine system disorders. Genetic factors, socioeconomic status, history of infection, and lifestyle factors were also examined as covariates and potential confounders. Results: Some of the questionnaires for children under 2 years old have already been collected. The numbers of patients with KD according to age were as follows: 14/71,133 (0.02%) between 0-6 months old, 102/51,351 (0.2%) between 6-12 months old, 71/34,595 (0.21%) between 12-18 months old, and 20/20,995 (0.1%) between 18-24 months old. According to these results, the estimated incidence of KD in children younger than 2 years old could reach more than 0.5%, but this number may increase after further collection of questionnaires. We also conducted a secondary survey regarding KD patients, including family history, clinical symptoms, laboratory data, treatment, and outcome. Conclusion: Recently, similar birth cohorts to JECS were already initiated in many countries, but this is the first large-scale birth cohort focusing KD. The results of this cohort may shed new light on the environmental pathogenesis of KD.