tbuckley/cabot-search huggingface dataset:
Magical thinking and imipramine poisoning in two school-age children
Authors: V. C. Herson
Journal: JAMA (1979)

Two young school-aged boys took an overdose of imipramine hydrochloride to help their enuresis. One child died, and the other required resuscitation. An office survey found that one third of school-aged children did not realize the potentially hazardous consequences of taking extra amounts of prescription medications. Physicians might be able to prevent similar needless tragedies by warning both the child and the parents of the unusual lethality of imipramine and other dangerous prescription drugs. (<i>JAMA</i>241:1926-1927, 1979)
Evidence for tuberculosis in a prehistoric population
Authors: A. J. Perzigian
Journal: JAMA (1979)

COMMENCING several thousand years before Christ and continuing to the time of European contact, the prehistory of eastern North America portrays a series of cultural adaptations. In the earliest periods, hunting and gathering were the exclusive economic pursuits; in the latest periods, agriculture was the primary pursuit. In a review of the paleopathologic literature, Buikstra<sup>1</sup>demonstrated that cases of prehistoric skeletal lesions, thought to be tuberculous, were more frequently reported for the later agriculturally based groups when compared with the earlier hunting and gathering groups. We think that this association between paleopathology and culture history is more than coincidental; indeed, the paleopathologic and paleoepidemiologic record of eastern North America closely mirrors human culture history. We report on skeletal lesions in six late prehistoric American Indians recovered from a burial mound at the Turpin Farm near Cincinnati. The site, excavated by the Cincinnati Museum of Natural History, yielded the remains
RELATION OF ORTHOPEDIC SURGERY TO INDUSTRIAL SURGERY
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical Neurosurgery
Authors: Oscar Sugar
Journal: JAMA (1978)

This annual will appeal to all surgical neurologists but should also be read by vascular surgeons and all who are interested in cerebral vascular disease. Particular emphasis is placed on cerebral revascularization, the new technique of anastomosing branches of the external carotid system to branches of the intracranial arteries to improve the blood supply to the cerebrum and cerebellum. Clinical evaluation and epidemiology of stroke, stroke in children, cardiac factors in stroke, hypertensive brain hemorrhage, diagnosis with radionuclide angiography, and complications of endarterectomy and aneurysm surgery have relevance for internists and pediatricians. Other chapters deal with complications of neurosurgical procedures not only in local problems such as CSF leaks, infection, and bleeding, but also in the more general pulmonary, fluid, and electrolyte problems. An insurance executive and two lawyers contribute chapters on malpractice insurance and litigation, and there is the more personal experience with malpractice litigation described by the Honored
DRUGGIST ETHICS.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Transport
Authors: Dean Gianakos
Journal: Annals of Internal Medicine (2006)

On Being a Doctor7 February 2006TransportDean Gianakos, MDDean Gianakos, MDFrom Lynchburg Family Medicine Residency, Lynchburg, VA 24501.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-144-3-200602070-00012 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail I love to see the last patient of the day. I won't deny it: The last patient reminds me that the day is coming to an end and that I will soon be going home to dine with my family. However, there are other reasons. When I see the final patient, I'm in my most relaxed state. There are no time pressures to see other patients. I am not distracted by phone calls, knocks on the door, or overhead pages. The work of the day, except for a few dictations, is almost done. I can sit back and give the ... Author, Article, and Disclosure InformationAffiliations: From Lynchburg Family Medicine Residency, Lynchburg, VA 24501.Corresponding Author: Dean Gianakos, MD, Lynchburg Family Medicine Residency, 2097 Langhorne Road, Lynchburg, VA 24501; e-mail, [email protected]com. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 7 February 2006Volume 144, Issue 3Page: 216KeywordsAsthmaChildrenNursesResidencyShouldersSystematic reviews ePublished: 7 February 2006 Issue Published: 7 February 2006 Copyright & PermissionsCopyright © 2006 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Angiotensin II inhibition. Treatment of congestive cardiac failure in a high-renin hypertension
Authors: H. Gavras
Journal: JAMA (1977)

A patient with intractable congestive cardiac failure secondary to renovascular hypertension and severe coronary artery disease was infused with the competitive antagonist of angiotensin II, saralasin acetate. The infusion produced an impressive increase in cardiac output and left ventricular stroke work index in parallel with a striking decrease in the systemic and pulmonary vascular resistance, the coronary resistance, and the myocardial oxygen consumption. It is suggested that angiotensin inhibition may present advantages over other forms of treatment of congestive cardiac failure in selected cases. (<i>JAMA</i>238:880-882, 1977)
John Weaver
Authors: B. A. P. B. D. Hadden
Journal: BMJ (2013)

<h3>Background</h3> Allopurinol is the most commonly used urate-lowering therapy, with rare but potentially fatal adverse effects. However, its impact on overall mortality remains largely unknown. In this study, we evaluated the impact of allopurinol initiation on the risk of mortality among individuals with hyperuricaemia and among those with gout in the general population. <h3>Methods</h3> We conducted an incident user cohort study with propensity score matching using a UK general population database. The study population included individuals aged ≥40 years who had a record of hyperuricaemia (serum urate level &gt;357 μmol/L for women and &gt;416 μmol/L for men) between January 2000 and May 2010. To closely account for potential confounders of allopurinol use and risk of death, we constructed propensity score matched cohorts of allopurinol initiators and comparators (non-initiators) within 6-month cohort accrual blocks. <h3>Results</h3> Of 5927 allopurinol initiators and 5927 matched comparators, 654 and 718, respectively, died during the follow-up (mean=2.9 years). The baseline characteristics were well balanced in the two groups, including the prevalence of gout in each group (84%). Allopurinol initiation was associated with a lower risk of all-cause mortality (matched HR 0.89 (95% CI 0.80 to 0.99)). When we limited the analysis to those with gout, the corresponding HR was 0.81 (95% CI 0.70 to 0.92). <h3>Conclusions</h3> In this general population study, allopurinol initiation was associated with a modestly reduced risk of death in patients with hyperuricaemia and patients with gout. The overall benefit of allopurinol on survival may outweigh the impact of rare serious adverse effects.
Erratum: The Duffy antigen receptor for chemokines transports chemokines and supports their promigratory activity
Authors: Monika Pruenster, Liesbeth Mudde, Paula Bombosi, Svetla Dimitrova, Marion Zsak, Jim Middleton, Ann Richmond, Gerard J Graham, Stephan Segerer, Robert J B Nibbs, Antal Rot
Journal: Nature Immunology (2009)

Nat. Immunol. 10, 101–108 (2009); published online 7 December 2008; corrected after print 16 January 2009 In the version of this article initially published, the images in Figure 2c,e were truncated. Intact images have replaced those versions. The error has been corrected in the HTML and PDF versions of the article.
Book Listings
Journal: Annals of Internal Medicine (2001)

Book Listings18 September 2001Book ListingsSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-135-6-200109180-00001 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail CardiologyAcute Myocardial Infarction and Other Acute Ischemic Syndromes2nd edition. RM Califf, ed. 232 pages. Philadelphia: Current Medicine; 2001. $125.00. ISBN 1573401595. Order phone 215-574-2266.The Adult with Tetralogy of FallotMA Gatzoulis and DJ Murphy Jr, eds. 95 pages. Armonk, NY: Futura; 2001. $30.00. ISBN 0879934905. Order phone 800-877-8761.Atlas of Atherosclerosis: Risk Factors and Treatment2nd edition. PW Wilson, ed. 269 pages. Philadelphia: Current Medicine; 2000. $125.00. ISBN 1573401374. Order phone 215-574-2266.Basic Dysrhythmias: Interpretation and Management3rd edition. RJ Huszar. 544 pages. St. Louis: Mosby–Year Book; 2002. $37.00. ISBN 0323012442. Order phone 314-872-8370.Cardiology Secrets2nd edition. OV Adair, ed. 343 ... Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 18 September 2001Volume 135, Issue 6Page: B1KeywordsComputed axial tomographyInterleukinsPrevention, policy, and public health ePublished: 18 September 2001 Issue Published: 18 September 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Necropsy Reports on 36 Cases of Endometrial Carcinoma
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
221PD Efficacy and safety of nanoliposomal irinotecan (nal-IRI, MM-398, PEP02, BAX-2398) in patients with metastatic pancreatic cancer in Asia: A subgroup analysis of the phase 3 NAPOLI-1 Study
Authors: L.-T. Chen, C.-P. Li, C.-F. Chiu, Y.-S. Shan, J.O. Park, J.-S. Chen, J.S. Kim, K.-M. Rau, F. de Jong, M. Pipas, B. Belanger, E. Wang, K.-H. Lee, Y.-J. Bang
Journal: Annals of Oncology (2016)
Vitamin Methods. Volume II
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Neuropsychological sequelae of cardiac arrest
Authors: R. O. Roine
Journal: JAMA (1993)

<h3>Objectives.</h3> —Prospective and community-based studies on the cognitive outcome of out-of-hospital cardiac arrest have not been published. We studied prospectively the neuropsychological sequelae of cardiac arrest and evaluated the effects of nimodipine on them. <h3>Design.</h3> —Placebo-controlled, randomized, double-blind trial of nimodipine compared with placebo in out-of-hospital ventricular fibrillation. <h3>Setting.</h3> —Urban area of 500 000 inhabitants served by the physician-manned Advanced Life Support Unit of Helsinki. <h3>Patients.</h3> —A total of 155 successfully resuscitated consecutive patients out of 677 resuscitation attempts during 2½ years. Sixty-eight survivors were examined by a neuropsychologist and a neurologist. <h3>Main Outcome Measure.</h3> —Neuropsychological outcome 3 months and 1 year after cardiac arrest. <h3>Interventions.</h3> —Nimodipine or placebo at a dosage of 10 γ/kg as an intravenous injection immediately after restoration of spontaneous circulation, followed by an infusion of 0.5 γg/kg per minute for 24 hours. <h3>Results.</h3> —Three months after cardiac arrest, 41 (61%) of 68 patients were found to have moderate to severe cognitive deficits. At 12 months, 26 (48%) of 54 survivors still had moderate to severe deficits, and the Symptom Check List 90—Revised score indicated the presence of depression in 22 patients (45%) and severe depression in 12 patients (24%). <h3>Conclusions.</h3> —Moderate to severe neuropsychological sequelae of out-of-hospital cardiac arrest are still present in approximately one half of the survivors at 1 year and may be permanent. There seems to be no excess of increased disability in the subgroup of patients with delayed advanced life support. Nimodipine failed to show any effect on the cognitive functions tested. (<i>JAMA</i>. 1993;269:237-242)
Incidence and distribution of HER2-positive gastric and gastroesophageal junction (GEJ) adenocarinomas in British Columbia (BC).
Authors: H. J. Lim, F. Aubin, C. Zhou, C. K. Kollmannsberger, R. Woods, B. Carter, D. Huntsman, S. Gill
Journal: Journal of Clinical Oncology (2011)

e14559 Background: HER2-positive rates have been reported as 20% of GC and 34% in GEJ adenocarcinoma in a recent global phase III trial with trastuzumab and chemotherapy. This study examines the incidence and distribution HER2-positive GC and GEJ adenocarcinomas in the province of BC. Methods: Formalin fixed embedded tissue from patients (pts) with resected gastric or GEJ adenocarcinoma from 2004-2007 were identified retrospectively through the BC Cancer Agency registry and prospectively for pts with a new diagnosis of advanced disease. Biopsies and resection samples were analyzed via previously validated methods IHC (Ventana 4B5 antibody), FISH (Eurovision probes) and SISH (Ventana probes). IHC scores of 3 were considered positive, 2 were cequivocal and 0 or 1 were negative. A 10% cut-off was used to determine positive samples. Equivocal staining was considered positive via FISH or SISH. A ratio of > 2.2 was considered amplified for FISH and SISH. P-values were calculated using a logistic regression model with HER2 positive as the endpoint. Results: 87 of the 285 samples have been scored, 64 (74%) were gastric and 23 (26%) GEJ. Overall, HER2 was positive 20% (IHC), 18% (FISH) and 18% (SISH). 13% of cases tested IHC 3+ while 24% tested IHC 2+. In equivocal IHC 2+ cases, 7% were considered positive by FISH.. Positivity rates were higher for GEJ (26%, 22% and 17%) vs. gastric (8%, 11% and 9%) via IHC (p=0.02), but did not significantly differ by FISH (p=0.19), or SISH (p=0.30) respectively. The majority of positive cases were intestinal type vs. other (diffuse type or mixed) 25% vs. 0% IHC p=0.0002, 25% vs. 3% FISH p=0.001, 20% vs. 3% SISH p=0.006. The positivity rates were similar with biopsy vs resection specimens (12% vs. 16% IHC p=0.64, 12% vs. 21% FISH p=0.30, 12% vs. 10%, SISH p=0.88). Conclusions: The rates of HER2-positive disease in a Western population based study were similar to the ToGA study, HER2 positivity was associated with cancers arising in the GEJ and of intestinal type. The frequency of positivity was similar for testing by biopsy versus resection specimens. This study is ongoing and updated results will be presented.
Osteopenia and decreased bone formation in osteonectin-deficient mice
Authors: A.M. Delany, M. Amling, M. Priemel, C. Howe, R. Baron, E. Canalis
Journal: Journal of Clinical Investigation (2000)

Figure 5 Trabecular bone-formation rate in tibiae of control (+/+) and osteonectin-null (-/-) mice.In vivo dual calcein labeling allows an estimate of bone-formation rate, which considers the distance between 2 fluorescent labels.Representative data from 11-week-old control (a) and osteonectin-null (b) mice are shown.Bars show mean ± SEM (n ≥ 4).A P < 0.01 between control and mutant mice, as determined by 2-way ANOVA.Osteopenia and decreased bone formation in osteonectin-deficient mice
Ovarian Tumors of the Hen
Authors: T. N. Fredrickson
Journal: Environmental Health Perspectives (1987)

Present available information regarding ovarian tumors in hens is incomplete in most aspects, and this lack of knowledge hampers use of hens as models for study of ovarian cancer. A study of 466 hens ranging from 2 to 7 years of age and covering a period of more than 3 years has provided much needed information relative to reproductive tract neoplasia. On the basis of this study, it is apparent that hens have a high rate of ovarian tumors, but that such tumors are uncommon in hens less than 2 years of age. Adenocarcinomas with a high degree of morphologic variability are the most common ovarian tumors in hens. Hormonal imbalance does not appear to be a factor in the development of these adenocarcinomas. Steroidogenic and morphologically distinctive granulosa cell tumors originating from follicles in atrophic ovaries represent another common ovarian tumor type. Unique to the hen are oviductal adenocarcinomas. These tumors arise from the albumin-secreting glands of the oviduct, occur with relatively high frequency, and must be differentiated from ovarian adenocarcinomas.
Sexual orientation and physicians' fitness for military duty
Authors: S. E. Harris
Journal: JAMA (1984)

<h3>To the Editor.—</h3> The Department of Defense excludes homosexual and bisexual physicians from military service because homosexuality is assumed to impair their ability to perform military duties and to impair their unit's ability to function. This letter reports survey data about a group of homosexual and bisexual physicians who served in the military despite its exclusionary policy. The data challenge the assumption that sexual orientation is related to physicians' fitness for military duty. The American Medical Association recognizes the San Francisco Bay Area Physicians for Human Rights, a professional organization committed to improving health care for homosexual and bisexual persons, as a valuable resource for information about sexual orientation.<sup>1</sup>To obtain information about the military service experience of homosexual and bisexual physicians, I mailed an anonymous questionnaire to the nearly 400 members of the Bay Area Physicians for Human Rights. A summary of the data reported by respondents follows.
Remains
Authors: Susan J. Sample
Journal: JAMA (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal