tbuckley/cabot-search huggingface dataset:
Abstract P226: Exploring the Impact of Genetics for a General Cardiovascular Health Phenotype
Authors: Jitender Kumar, Anders Hamsten, Patrik K Magnusson, Nancy L Pedersen, Erik Ingelsson
Journal: Circulation (2012)

A large number of genetic factors have recently been robustly associated with various individual cardiovascular traits, but less is known about genetic determinants of overall cardiovascular health; a trait that may reflect pleiotropic effects, as well as pathways involved in longevity. In order to find genetic factors responsible for maintaining general cardiovascular health, we performed meta-analyses of genome-wide association (GWA) data from two population-based cohorts. The TWINGENE cohort includes twins from Sweden born before 1958 (mean age, 64.9 years; 55% women), and the ULSAM cohort includes men born between 1920 and 1924 in Uppsala County, Sweden (mean age at DNA draw, 71.0 years). The present study was performed in 10,844 participants (9,740 and 1,104 from TWINGENE and ULSAM, respectively) with complete data on genotypes (Illumina OmniExpress in TWINGENE and Illumina CardioMetabochip in ULSAM) and phenotypes. Individuals without previously known coronary heart disease (CHD), heart failure, stroke, diabetes and hypertension, who had normal BMI (18.5-24.9 kg/m2), were normotensive (systolic blood pressure ≤140 mmHg), and had a preferable lipid profile (ratio of total cholesterol/high density lipoprotein ≤4.0) and HbA1c levels &lt;6.5% were defined as cardiohealthy. We performed single marker association analyses with the cardiohealth phenotype as outcome using an additive genetic model adjusting for age, sex and smoking in PLINK (taking twinness into account for TWINGENE cohort). Summary statistics were subsequently meta-analyzed using inverse variance method in METAL. A total of 1,075 individuals (mean age, 61.5 years; 73% women) in TWINGENE and 54 individuals (mean age, 71.0 years) in the ULSAM cohort were identified as cardiohealthy. A non-synonymous variant (rs5880; Ala390Pro) in the CETP gene showed the strongest evidence for association (1.8*10-7). CETP encodes cholesteryl ester transfer protein, a key regulator of reverse cholesterol transport, and variants in this gene have been associated with several cardiovascular traits in recent GWA studies, such as CHD, metabolic syndrome and lipid fractions. Other genetic variants showing borderline significant association with the cardiohealthy phenotype included variants in or near ACCN1 that has been associated with factor VIII and von Willebrand factor, ATP6V04A that has been associated with F-cell level and SNX10 with smoking behavior. In the present meta-analysis comprising 10,844 individuals from the general population, we identified several genetic variants exhibiting suggestive association with cardiohealthy status. A few of these variants may exhibit pleiotropic effect modulating various risk factors involved simultaneously, thereby contributing towards cardiohealthy outcome. We are currently pursuing further replication and biological follow-up studies of these potential associations.
Diagnostic Reasoning
Authors: David M. Mitchell
Journal: Annals of Internal Medicine (2018)

Letters15 May 2018Diagnostic ReasoningDavid M. Mitchell, MD, PhDDavid M. Mitchell, MD, PhDMountain States Health Alliance, Russell County Medical Center, Lebanon, Virginia (D.M.M.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L18-0010 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:As a former hospital medicine inpatient teaching attending and a hospitalist with 15 years of experience in several states, groups, and hospital sizes, I agree with Simpkin and colleagues (1) that the practice of diagnostic reasoning is sadly fading quickly in inpatient medicine. However, I believe that education is not the sole problem or the final solution. Financial and time-related pressures are turning even well-trained “thinking” residents into inpatient triage robots unfortunately retrained to stop thinking and instead focus on generating more revenue, building higher case-mix indices, and producing higher patient satisfaction and quality scores rather than ...Reference1. Simpkin AL, Vyas JM, Armstrong KA. Diagnostic reasoning: an endangered competency in internal medicine training. Ann Intern Med. 2017;167:507-8. [PMID: 28892818]. doi:10.7326/M17-0163 LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Mountain States Health Alliance, Russell County Medical Center, Lebanon, Virginia (D.M.M.)Disclosures: The author has disclosed no conflicts of interest. The form can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L18-0010. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoDiagnostic Reasoning: An Endangered Competency in Internal Medicine Training Arabella L. Simpkin , Jatin M. Vyas , and Katrina A. Armstrong Diagnostic Reasoning Paul F. Griner Diagnostic Reasoning Arabella L. Simpkin , Jatin M. Vyas , and Katrina A. Armstrong Diagnostic Reasoning Liliana Grigorita , Andreea Stan , and Boban Thomas Metrics 15 May 2018Volume 168, Issue 10Page: 750KeywordsEmergency departmentEpileptic seizuresHospital medicineHospitalistsInpatientsReasoningSepsisTemperatureTriageTroponin ePublished: 15 May 2018 Issue Published: 15 May 2018 Copyright & PermissionsCopyright © 2018 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Troponin T and I to predict 6 month mortality and relative benefit of invasive vs. conservative strategy in patients with unstable angina: Primary results of the TACTICS-TIMI 18 troponin substudy Christopher P. Cannon, William S. Weintraub, Laura Demopoulos, Ralph Vicari, Martin J. Frey. Nasser Lakkis, DebbieRobertson, Paul deLucca, Nader Rifai, Eugene Braunwald, for the TACTICS-TIMI 18 Investigators. Bringam and Women's Hospital, Boston, MA
Journal: Journal of the American College of Cardiology (2001)
Migraine
Authors: Seymour Diamond
Journal: JAMA (1994)

During the last five years, there has been a plethora of books published on headaches. This profusion is probably due to the multitude of investigations into headache as well as the extensive availability of newer therapies for cephalalgic patients. However, this revised and expanded edition of Oliver Sacks'<i>Migraine</i>is a welcome addition. Dr Sacks' previous books,<i>Awakenings</i>and<i>The Man Who Mistook His Wife for a Hat</i>, have stimulated enormous lay interest in the neurological sciences. This revised edition of<i>Migraine</i>, although directed to a general readership, should be added to the library of any physician caring for headache patients. The author has produced a readable text that provides insight into, and knowledge of, a complex and poorly understood disorder. The first two of five parts, "The Experience of Migraine" and "The Occurrence of Migraine," similar to the previous edition, include simplified yet accurate descriptions of symptoms and intricacies.
A medical version of the Faust legend
Authors: M. C. Meehan
Journal: JAMA (1966)

Although the legend of Faust, the scholar who sold his soul to the devil, has been a popular subject for literary works since the 16th century, it was not until mid-20th century that a medical interpretation was given to the story. Previous writers had portrayed the devil as an actual personification of evil or as an imaginary symbolic character. They made no attempt to interpret Faust's behavior in psychiatric terms. Thomas Mann, the German novelist, in his<i>Doctor Faustus</i>, showed the devil as imaginary or hallucinatory, but the pact with him as real, in that the protagonist willingly accepted syphilis of the central nervous system as a means to greater artistic creative power. <h3>Early Versions</h3> Dr. Johannes Faustus was evidently a real individual who lived in the 15th and early 16th centuries, about whom many odd stories were told. Between 1570 and 1587, these were gathered in manuscript form, and
CEPHALIC INDEX AND HEIGHT, WEIGHT, STRENGTH AND MENTAL ABILITY.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Collateral Ventilation
Authors: Peter T. Macklem
Journal: New England Journal of Medicine (1978)

OF what importance is collateral ventilation in man? Perhaps the best way to begin to answer this question is to describe what happens when airways become occluded in the absence of collateral ventilation. Under these circumstances the alveolar gas tensions beyond the occlusion rapidly equilibrate with mixed venous gas tensions, no further gas exchange occurs, and an intrapulmonary right-to-left shunt develops. Eventually, the alveolar gas is absorbed, and atelectasis develops.1 In the dog occlusion of airways smaller than lobar bronchi has quite a different result. Gas sampled from alveoli beyond the occlusion has a partial pressure of carbon dioxide (PCO . . .
A single measure of urinary neutrophil gelatinase–associated lipocalin was accurate for diagnosing acute kidney injury
Authors: Anna Mathew
Journal: Annals of Internal Medicine (2008)

Source Citation Nickolas TL, O′Rourke MJ, Yang J, et al. Sensitivity and specificity of a single emergency department measurement of urinary neutrophil gelatinase-associated lipocalin for diagnosing acute kidney injury. Ann Intern Med. 2008;148:810-9. 18519927
Attitudes of internal medicine faculty and residents toward professional interaction with pharmaceutical sales representatives
Authors: W. P. McKinney
Journal: JAMA (1990)

We surveyed faculty and residents from seven hospitals affiliated with three academic internal medicine training programs about their perceptions of the informational and service benefits vs the risks of ethical compromise involved in interactions with pharmaceutical sales representatives. Questionnaires were returned by 467 (81%) of 575 physicians surveyed. Residents and faculty generally had somewhat negative attitudes toward the educational and informational value of detailing activities at their institutions but indicated that representatives supported important conferences and speakers. Residents were more likely than faculty to perceive contacts with sales representatives as potentially influencing physician decision making. Sixty-seven percent of faculty and 77% of residents indicated that physicians could be compromised by accepting gifts. More than half of the physicians who suggested that such compromise was possible indicated that acceptance of gifts worth more than $100 from drug companies would be likely to compromise a physician's independence and objectivity. A majority of both faculty and house staff favored eliminating presentations by pharmaceutical representatives at their hospitals. Only 10% thought they had had sufficient training during medical school and residency regarding professional interaction with sales representatives. (<i>JAMA</i>. 1990;264:1693-1697)
THE CINCINNATI EXPERIMENT WITH ORAL ATTENUATED POLIOVIRUS VACCINE
Journal: JAMA (1961)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diseases of Women: Symptoms and Treatment.
Journal: JAMA (1929)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Valvular-ventricular remodeling and mitral leaflet geometry in dilated cardiomyopathy David T. M. Lai, Paul Dagum, Tomasz A. Timek, Frederick A. Tibayan, David Liang, George T. Daughters, II, Neil B. Ingels, Jr., D. C. Miller. Stanford University School of Medicine, Stanford, CA, Research Institute of the Palo Alto Medical Foundation, Palo Alto, CA
Journal: Journal of the American College of Cardiology (2001)
Abstract O.63: Novel Use Of Fractal Analysis In Kawasaki Disease For Risk Prediction
Authors: Terence C W Lim, Carol Y Cheung, Swee Chye Quek, Peng Guan Ong, Inez B Wong, Robert G Grignani, Tien Y Wong
Journal: Circulation (2015)

Introduction: Fractal based analysis of vascular branching complexity is known to have a prognostic role in cardiovascular risk prediction and suboptimal Fractal Dimensions of retinal vessels has been shown to correlate with coronary mortality. We hypothesize that Kawasaki disease permanently alters the fractal pattern of the retinal vasculature reflecting suboptimal microcirculatory development and attendant coronary risk. Objectives: We calculated and compared the Zone Fractal Dimension(D f ) of children with a history of Kawasaki disease with a matched cohort Methods: All subjects underwent high resolution digital retinal photography and disc-as well as macular centered photographs were digitized and used for measurement of D f using a standardized validated program performed by a single trained grader. Retinal vascular dimensions were also measured Results: Fifty subjects and 100 controls were examined. Subjects had a D f f 1.506 while controls had a Df of 1.432(P&lt;0.001). Cases were controlled for age, gender and ethnicity. Conclusion: In adult studies, a D f exceeding 1.47 has been shown to be sub-optimally high with resultant associated coronary risk. This suggests that the long term cardiovascular risks of Kawasaki disease may not only be conferred through coronary flow factors but systemic microcirculatory mal-development.
Internal biliary drainage, unlike external drainage, does not suppress the regeneration of cholestatic rat liver after partial hepatectomy
Authors: H Suzuki
Journal: Hepatology (1994)

We previously showed that hepatic cells proliferate in obstructive jaundice alone without partial hepatectomy and found that external biliary drainage for obstructive jaundice markedly suppresses liver regeneration after partial hepatectomy. In this study, we produced a model system for internal biliary drainage in which bile was drained into the stomach of rat fed a liquid diet. The regeneration capacity of the liver was assessed on the basis of the induction of DNA polymerase-α activity, as well as the mitotic index of hepatic cells. A remarkable difference was observed in the regeneration capacities of cholestatic livers between two groups—one in which jaundice was released by the internal and one by external biliary drainage before hepatectomy. After 5 days of internal biliary drainage, the regeneration capacity remained at a level comparable to that of sham-operated control rats, in sharp contrast to the impaired regeneration after external biliary drainage. These results clearly indicate that internal biliary drainage is preferable for release of biliary obstruction before partial resection of cholestatic liver. (Hepatology 1994;20:1318–1322).
A phase I dose-escalation study of the Hsp90 inhibitor STA-9090 administered once weekly in patients with solid tumors.
Authors: J. W. Goldman, R. N. Raju, G. A. Gordon, V. M. Vukovic, R. Bradley, L. S. Rosen
Journal: Journal of Clinical Oncology (2010)

2529 Background: STA-9090 is a potent, next-generation Hsp90 inhibitor that is structurally unrelated to the first-generation ansamycin class of Hsp90 inhibitors, such as 17-AAG and IPI-504, and has shown superior activity and an improved safety profile relative to these agents in preclinical studies. Methods: In a standard 3 + 3 dose escalation trial, advanced cancer patients received STA-9090 as a 1-hr infusion once weekly for 3 weeks of a 28-day cycle. Blood samples for PK and biomarker analyses were collected in cycle 1. Safety assessments included the number and grade of AEs, changes from baseline in laboratory parameters, and ECG changes. Results: 35 patients (17 M, 18 F; median age 61 yrs, range 37-87; ECOG status range 0-2) received doses ranging from 7-259 mg/m2 once weekly. There have been 3 DLTs: 1 at 150 mg/m2 (grade 3 amylase elevation) and 2 at 259 mg/m2 (grade 4 fatigue and grade 3 diarrhea). The MTD is 216 mg/m2. AEs reported in ≥ 20% of patients were diarrhea, anemia, fatigue, abdominal pain, nausea, elevated alk phos, constipation and dyspnea; most of these AEs were mild to moderate in severity. STA-9090 shows linear PK and has a mean terminal half life of 5-13 hours with no accumulation. Preliminary signs of clinical activity have been observed including a durable PR in a patient with rectal carcinoma, as well as several cases of tumor shrinkage and prolonged SD in patients with tumors including NSCLC, renal cell carcinoma and GIST, who were treated for 16 to 48 weeks. Conclusions: STA-9090 has been well tolerated up to dose levels of 216 mg/m2 given once weekly, without significant liver toxicity. Preliminary safety and activity signals warrant continued evaluation of single-agent STA-9090 using once weekly dosing. Author Disclosure Employment or Leadership Position Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Synta Synta
Oral clindamycin for asymptomatic bacterial vaginosis in early pregnancy reduces premature births
Journal: BMJ (2003)

represents the first time that WHO has used its constitutional authority to develop a legal instrument for improving health.Drawing on scientific evidence, the convention includes measures relating to reducing the demand for tobacco (price and tax measures, restrictions on tobacco advertising) and the supply of tobacco (restriction of sales to minors, economically viable alternatives for growers).The authors state that these interventions could reduce the global burden of disease attributable to tobacco by up to 60%.
CONSULTANTS TO JAMA, 1965
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal