tbuckley/cabot-search huggingface dataset:
<i>Erratum:</i> Vol. 67, No. 45
Journal: MMWR Morbidity and Mortality Weekly Report (2019)

In Table 2 of the report "Suicide Rates by Major Occupational Group -17 States, 2012 and 2015," on page 1255, some percentages were calculated using records with Standard Occupational Classification (SOC) codes as the denominator rather than all suicide decedents aged 16-64 years.The corrected Table 2 follows.The ranking of occupational groups by suicide rate is unaffected by this correction.On page 1254, the first sentence of the second complete paragraph should have read, "In both 2012 and 2015, the largest percentage of male suicides (15%-16% of decedents) occurred among those in the Construction and Extraction group (SOC 47) (Table 2); the largest percentage of female suicides in both years occurred among decedents with unpaid occupations (29%).The largest percentage of female suicides among classifiable occupations occurred in the Office and Administrative Support group (SOC 43) in both years (9% and 10%)."
Medical Classics
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lung cancer cell type and asbestos exposure
Authors: A. Churg
Journal: JAMA (1985)

It is often claimed that adenocarcinoma is the most frequent type of lung cancer seen in workers exposed to asbestos. Careful review of the published data, however, fails to support this claim. Rather, it seems that all types of lung cancers occur in asbestos workers, and the presence or absence of a specific cell type cannot be used to prove or disprove an association of carcinoma and asbestos exposure. (<i>JAMA</i>1985;253:2984-2985)
Echocardiography
Authors: Lewis Sasse
Journal: JAMA (1986)

This is the fourth edition of one of the most comprehensive books about echocardiography. With the exception of the chapter concerning congenital heart disease by W. F. Armstrong, MD, associate professor of medicine and colleague of Dr Feigenbaum at Indiana University School of Medicine, Indianapolis, this remains a single-authored work. The organization and chapter headings are identical to the previous edition, but the text has been expanded from 563 to 639 pages. Even the traditional cover of the previous three editions showing M-mode and then two-dimensional images of left and right atrial myxomas has been changed to a two-dimensional image of ischemic heart disease and Doppler and M mode of mitral insufficiency and elevated left ventricular enddiastolic pressure. The book is clinically and physiologically oriented and is written in a most readable style, which eliminates all but the most essential technical terms and formulas. Bibliographies at the end of each
A phase 2 trial of low-dose multiagent chemotherapy with gemcitabine, docetaxel, capecitabine, and cisplatin (GTX-C) in subjects with metastatic pancreatic cancer.
Authors: Dung T. Le, Daniel A. Laheru, Katrina Purtell, Jennifer N. Uram, Hao Wang, Susie Lawrence, Rose Parkinson, Ellen-Lilly Foreman, Dionne T Savage, Jacob Joseph-David, Ross C. Donehower, Zeshaan Rasheed, Lei Zheng, Nilofer Saba Azad, David Cosgrove, Ana De Jesus-Acosta, Ilene S. Browner, Luis A. Diaz
Journal: Journal of Clinical Oncology (2014)

4135 Background: Triplet chemotherapy has been shown to delay the emergence of resistance and extend survival in patients with metastatic pancreatic adenocarcinoma. Four drug regimens, even at low doses, may further improve survival by simultaneously targeting multiple oncogenic pathways. Methods: A phase 2 study of GTX-C (capecitabine 500 mg bid on days 1-14, and the combination of gemcitabine 500 mg/m2 [10 mg/m2/min], docetaxel 20 mg/m2 and cisplatin 20 mg/m2 on days 4 and 11) was initiated in newly diagnosed untreated metastatic pancreatic cancer patients. The primary endpoint was progression-free survival rate at 6 months and designed such that the regimen would be considered active if the 6-month PFS rate was >75% and inactive if < 50%. Results: Twenty-eight patients were enrolled. All patients were ECOG 0-1. Eighty-six percent of patients had evidence of liver metastases and 25% had biliary stents in place at time of study initiation. Median CA19-9 was 6,159 U/mL (37-154,323 U/mL). Median length of follow-up was 10.1 months. Grade 3/4 related adverse events included: nausea/vomiting (7%), transaminitis (10%), anemia (14%), thrombocytopenia (24%), and neutropenia (55%). However, febrile neutropenia occurred in only 3 patients (10%) and not until cycles 6, 14, and 15. PFS rate at 6 months was 74.2% (95% CI: 53.3% - 86.8%). The partial response (PR) rate was 50%, stable disease (SD) rate was 39% and the disease control rate (DCR) was 89%. CA19-9 declines of >80% occurred in 77% of patients with measurable levels. Estimated median PFS was 8.4 months (95% CI: 6.1-10.6 months) and OS was 12.9 months (95% CI: 10.0-NA months) as of 11/14/2013. Ten additional patients have been enrolled onto an expansion cohort in which the period off between cycles has been changed from 7 to 14 days. Conclusions: GTX-C is highly active and well-tolerated in patients with metastatic pancreatic cancer and should be tested in a larger, comparative study. Clinical trial information: NCT01459614.
The Cover
Authors: Kate Whetzle
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction to Author’s Name in Byline
Journal: JAMA Neurology (2020)

Roland Veltkamp, MD; Lesly A. Pearce, MS; Eleni Korompoki, MD; Mukul Sharma, MD; Scott E. Kasner, MD; Danilo Toni, MD, PhD; Sebastian F. Ameriso, MD; Hardi Mundl, MD; Turgut Tatlisumak, MD, PhD; Graeme J. Hankey, MD; Arne Lindgren, MD, PhD; Scott D. Berkowitz, MD; Antonio Arauz, MD, PhD; Serefnur Ozturk, MD; Keith W. Muir, MD; Ángel Chamorro, MD, PhD; Kanjana Perera, MBBS; Ashfaq Shuaib, MD; Salvatore Rudilosso, MD; Ashkan Shoamanesh, MD; Stuart J. Connolly, MD; Robert G. Hart, MD
NCCN NewsNCCN Announces New Chief Medical OfficerNCCN Begins Work on Guidelines to Improve Cancer Care in the CaribbeanNew Tool Helps People with Leukemia Better Understand Their Treatment OptionsNew Translations of NCCN Guidelines for Patients Advance Global Mission to Empower People with Cancer
Authors: Wui-Jin Koh, Robert Carlson, Benjamin Greer
Journal: Journal of the National Comprehensive Cancer Network (2018)

He specializes in the treatment of gynecologic and gastrointestinal malignancies.The new CMO role will include overseeing the NCCN Oncology Research Program (ORP), which strives to improve and prolong the lives of people with cancer by advancing collaborative research.Dr. Koh will also
Antibodies against glycoprotein 2 and anti-neutrophil cytoplasmic antibodies targeting the serine proteinase 3 are markers of severe primary sclerosing cholangitis (PSC) and progression to cholangiocarcinoma (CCA)
Authors: Ewa Wunsch, Dirk Roggenbuck, Gary L. Norman, Małgorzata Milkiewicz, Marcin Krawczyk, Mary Ann Aure, Chelsea Bentow, Michael Mahler, Steffi Lopens, Piotr Milkiewicz
Journal: Journal of Hepatology (2020)
International Clinics. A Quarterly of Illustrated Clinical Lectures and Especially Prepared Original Articles on Treatment, Medicine, Surgery, Neurology, Pediatrics, Obstetrics, Gynecology, Orthopedics, Pathology, Dermatology, Ophthalmology, Otology, Rhinology, Laryngology, Hygiene, and Other Topics of Interest to Students and Practitioners. By Leading Members of the Medical Profession Throughout the World.
Journal: JAMA (1904)

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Generation of Reactive Species and Fate of Thiols during Peroxidase-Catalyzed Metabolic Activation of Aromatic Amines and Phenols
Authors: David Ross, Peter Moldeus
Journal: Environmental Health Perspectives (1985)

The horseradish peroxidase (HRP)-catalyzed oxidation of p-phenetidine and acetaminophen was investigated. Studies using the spin probe 2-ethyl-1-hydroxy-2,5,5-trimethyl-3-oxazolidine (OXANOH) suggested these oxidations involve the generation of substrate-derived free radicals. This was confirmed by using glutathione (GSH) in these incubations in the presence of the spin trap 5,5-dimethyl-1-pyrroline-N-oxide (DMPO). DMPO-glutathionyl radical adducts were observed using EPR spectroscopy during HRP-catalyzed oxidation of both p-phenetidine and acetaminophen. Investigations of oxygen uptake and oxidized glutathione (GSSG) formation during HRP-catalyzed oxidations of p-phenetidine and acetaminophen suggested that further reactions of the glutathionyl radical involve glutathione peroxysulfenyl radical and glutathione sulfenyl hydroperoxide production. Quinonoid products of the peroxidatic oxidations of p-phenetidine and acetaminophen, and their interaction with GSH via both conjugation and redox mechanisms are described. The relevance of these reactions of GSH with reactive species as detoxification mechanisms is discussed.
Response to ‘Serological diagnostics in the detection of IgG autoantibodies against human collagen VII in epidermolysis bullosa acquisita: a multicentre analysis’
Authors: M.F. Jonkman, J.M. Meijer, G.F.H. Diercks, H.H. Pas
Journal: British Journal of Dermatology (2017)

We appreciate the chance we have been given to address the critical comments raised by Jonkman et al. 1 regarding the key messages of our multicentre study of epidermolysis bullosa acquisita (EBA).As stated in the 'Materials and methods' section in our article, 'all of the sera were from patients with EBA with positive DIF and were positive in at least one serological test (IIF/ ELISA/WB)'. 2 This is the current gold standard for establishing
Pinpointing Melanoma's Invasive Trigger
Journal: Cancer Discovery (2015)

Abstract New research shows that melanoma's transition to an invasive and subsequently metastatic disease is triggered by direct contact between melanoma cells and differentiated keratinocytes in the epidermis, which in turn sparks Notch signaling. Understanding the molecular events that occur early on in this disease may enable the development of therapeutic strategies to keep its aggression at bay.
Cat leukemia.
Authors: M Penrose
Journal: BMJ (1970)

matter, and perfume.'It has been found that both the quaternary ammonium compounds and the amido-amines give positive results with tests for proteinuria using tetrabromo- phenolphthalein and tetrabromophenol blue (Albustix).Since our health visitors have advised the mothers to place the filter- paper in nappies not treated with fabric softeners the incidence of false positive tests has markedly fallen.
From Other Pages
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Crocidolite Activates NF-kB and MIP-2 Gene Expression in Rat Alveolar Epithelial Cells. Role of Mitochrondrial-Derived Oxidants
Authors: Kevin E. Driscoll, Janet M. Carter, Brian W. Howard, Diana Hassenbein, Yvonne M. W. Janssen, Brooke T. Mossman
Journal: Environmental Health Perspectives (1998)

Nuclear factor kappa B (NF-KB) is a transcription factor that regulates expression of several genes coding for inflammatory and immunoregulatory proteins including the neutrophil chemotactic cytokine MIP-2.In previous studies we found that crocidolite asbestos activates the nuclear translocation of NF-cB as well as MIP-2 gene expression in rat alveolar type 11 cells.Here we report that both crocidolite-induced NF-KB activation of MIP-2 gene expression can be attenuated by the antioxidant tetramethylthiourea, suggesting the dependence of these responses on oxidative stress.Crocidolite exposure of RLE-TN cells also increased production of H202, a response that was inhibited by the mitochondrial respiratory chain inhibitor thenoyltrifluoroacetone (TTFA).TTFA treatment of RLE-6TN cells also inhibited crocidolite-induced nuclear translocation of NF-KB and MIP-2 gene expression.These results indicate crocidolite exposure of rat alveolar type 11 cells results in increased production of mitochrondrial-derived hydrogen peroxide and that mitochrondrial-derived oxidants contribute to crocidolite activation of NF-KB and increases in MIP-2 gene expression.
Public Health and Poor.Law Medical Services
Journal: BMJ (1880)

Let Miss Lonsdale see the Ist of October at Guy's: the "old boys"' visits to "sister".One understands then the beneficial influence a good loving liberal minded woman may exercise over young gentlemen, many of them, far from home ties; how her hearty sympathy and kindly advice may save them from many a misadventure.Their own mothers are scarcely prouder of their successes, or more grieved over th-eir failures.Such was the old type of Guy's sisters.Can any one dare assert the " new type" is an improvemient?My picture is not overdrawn.The one sister of whom I am specially thinking has, after fourteen years' faithful service, been dismissed, because hcrcollar was ntot -egutlationt size-a grave offence under the new re'gimne.But Guy's men, past and present, will not soon forget such a sister, beloved alike by her surgeons, her " boys", and her nurses.-Iam, sir, yours obediently, OLD TYPE.
Mutagenicity Studies of Vinyl Chloride
Authors: Jill D. Fabricant, Marvin S. Legator
Journal: Environmental Health Perspectives (1981)

Mutagenicity studies in both man and in test organisms clearly demonstrate positive mutagenic activity of vinyl chloride. In terms of the mutagenicity studies using a variety of in vitro procedures covering both eukaryotes and prokaryotes, positive effects were found. Cytogenetic in vivo studies in animals and in humans indicate not only somatic mutations, but also germinal effects with this chemical.
Marine animals in medical research
Authors: A. Smith
Journal: JAMA (1979)

PHAGOCYTOSIS, probably everyone would agree, is a key component in the defense armamentarium of man. Yet its importance was first realized in studies with a marine creature, the starfish larva.<sup>1</sup>This discovery was exceptional. In general, few researchers until recently were cognizant of the value of marine animals in studying fundamental processes of relevance to man. Within the last decade, however, there have been a number of articles describing the special attributes of these animals and forecasting noteworthy benefits from their increased use in medically oriented research.<sup>2-5</sup>At the national level, it was recognized that there is a need for more scientists trained in the combination area of marine biology and health science.<sup>6</sup> <h3>Cause for Underuse</h3> Yet today, despite this generally stimulating literature, it is rare to find marine animals being used in substantial numbers by the medical researcher, and the question is why. A probable basic
DENTAL CARIES
Authors: Leo F. Rettger
Journal: JAMA (1934)

<h3>To the Editor:—</h3> I have read with interest the editorial on dental caries published inThe Journal, February 17, and I would like to submit the following comment: There have appeared recently in several periodicals (including<i>Science</i><b>78</b>:419 [Nov.] 1933) articles by Bunting and his associates in the University of Michigan which claim emphatically, and with an air of finality, that the etiology of dental caries has been fully established by them, and that Lactobacillus acidophilus is the active causative agent. Such an assertion, if based on adequate scientific evidence, would in the last analysis imply three things: (1) that caries is caused by a specific organism; (2) that the organism is a lactobacillus, and (3) that the lactobacillus is unequivocally L. acidophilus. The bacterial etiologic concept still lacks general support. This is revealed by a general review of papers appearing in dental journals, and by unpublished statements
IDU and Cytosine Arabinoside in Experimental Herpetic Keratitis
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mutation Load Offers Biomarker in SCLC
Journal: Cancer Discovery (2017)

Abstract Tumor mutation burden offers a promising predictive biomarker for patients with small cell lung cancer. An exploratory analysis presented at the World Conference on Lung Cancer showed that the patients with large numbers of mutations in their cancer cells were more likely to respond—and for a longer time—to a single checkpoint inhibitor or a combination of them than those with a low mutation load.
MILK SUPPLY IN NEW YORK.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cardiac Resuscitation
Authors: M. Aminoff, M. Asghar, S. L. Beeston, K. D. Bhoola, J. A. Child, K. C. Cunningham, J. R. Garnham, J. G. R. Jones, A. F. Kasenally, P. A. Kitchener, D. W. Littlejohn, D. Lotfi, R. L. MacDonald, F. J. F. Madden, S. A. Moussalli, B. Myles, D. J. Newton, T. G. Pickering, T. Price, R. S. Rawal, N. R. Davies, M. D. Ryan, J. Schlicht, A. E. Tattersfield, A. Tomkins, A. Triscott
Journal: BMJ (1967)
Studies in myasthenia gravis. Short-term massive corticotropin therapy
Authors: K. E. Osserman
Journal: JAMA (1966)

Modern management of myasthenia gravis has markedly improved prognosis in instances of crisis and has made thymectomy a safe and essentially uneventful procedure. A small core of patients with refractory myasthenia unresponsive to drug adjustment, adjuvant medication, and thymectomy occupy, today, the bulk of hospital beds for this disease. In an attempt to solve this problem 25 short-term courses of corticotropin as a single or "paired" course were administered in massive dosage to 11 hospitalized patients, with gratifying results.