tbuckley/cabot-search huggingface dataset:
Clinical activity of the RET inhibitor pralsetinib (BLU-667) in patients with RET fusion+ solid tumors.
Authors: Vivek Subbiah, Mimi I-Nan Hu, Justin F. Gainor, Aaron Scott Mansfield, Guzman Alonso, Matthew H. Taylor, Viola Weijia Zhu, Pilar Garrido Lopez, Alessio Amatu, Robert C Doebele, Philippe Alexandre Cassier, Bhumsuk Keam, Martin H. Schuler, Hui Zhang, Corinne Clifford, Michael Palmer, Jennifer Green, Christopher D. Turner, Giuseppe Curigliano
Journal: Journal of Clinical Oncology (2020)

109 Background: RET gene fusions are targetable oncogenic drivers in multiple tumor types, including up to 20% of papillary thyroid cancers (PTC). Pralsetinib is an investigational, highly potent, selective inhibitor of oncogenic RET alterations. In the registration-enabling Phase 1/2 ARROW study (NCT03037385), pralsetinib demonstrated an overall response rate (ORR; response-evaluable patients [REP], central review) of 73% (19/26) in treatment-naïve patients and 61% (49/80; 2 pending confirmation) in platinum-exposed patients with RET fusion+ non-small cell lung cancer (NSCLC) and was well tolerated (data cut-off November 18, 2019). We provide an update on the clinical activity of pralsetinib in other RET fusion+ solid tumor types. Methods: ARROW consists of a phase 1 dose escalation (30–600 mg once [QD] or twice daily) followed by a phase 2 expansion (400 mg QD) in patients with advanced RET-altered solid tumors. Primary objectives were ORR and safety. Results: As of November 18, 2019, 29 patients with metastatic solid tumor types other than NSCLC (16 PTC, 1 undifferentiated thyroid, 3 pancreatic, 3 colon, 6 other) bearing a RET fusion have received pralsetinib. Efficacy data are presented for REP enrolled by July 11, 2019. In patients with thyroid cancer that is RET fusion+, ORR (investigator assessment) was 75% (9/12; all confirmed). Median (range) duration of response (DOR) was 14.5 (3.7+, 16.8) months (mo), with 67% of responding patients continuing treatment. Two patients with stable disease were continuing treatment at 11.5+ and 19.3+ mo. In other RET fusion+ cancers, ORR was 60% (3/5; all confirmed) with partial responses in 2/2 patients with pancreatic cancer (DOR 5.5, 7.4+ mo) and 1 patient with intrahepatic bile duct carcinoma (DOR 7.5 mo). Two patients with colon cancer had stable disease for 7.3 and 9.3 mo. Responses were observed across multiple fusion genotypes. In the entire safety population (all patients treated with 400 mg QD pralsetinib, regardless of diagnosis; n = 354), most treatment-related adverse events (TRAEs) were grade 1-2, and included increased aspartate aminotransferase (31%), anemia (22%), increased alanine aminotransferase (21%), constipation (21%) and hypertension (20%). Only 4% of patients in the safety population discontinued due to TRAEs. Conclusions: Pralsetinib demonstrated broad and durable antitumor activity across multiple advanced solid tumor types, regardless of RET fusion genotype, and was well tolerated. The study is ongoing and still enrolling patients in this cohort. Clinical trial information: NCT03037385.
Reversal of myocardial interstitial fibrosis in the cardiac troponin T-Q92 transgenic mouse model of human hypertrophic cardiomyopathy with angiotensin II receptor 1 blockade Do-Sun Lim, Rajnikant Patel, Silvia Lutucuta, Pavan Bachireddy, Keith Youker, A. Evans, Mark Entman, Robert Roberts, Ali J Marian. Baylor College of Medicine, Houston, TX
Journal: Journal of the American College of Cardiology (2001)
FACTORS IN THE PRODUCTION OF EDEMA
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PULSE
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Rehabilitation after myocardial infarction
Authors: N. K. Wenger
Journal: JAMA (1979)

The concept that many patients with symptomatic coronary atherosclerotic heart disease, including myocardial infarction, can and should return toward normal living is the basis of the rehabilitation effort. The primary care physician is increasingly employing this approach in the care of patients with myocardial infarction. Much of the capacity to effect rehabilitation should be available in the community hospital, in the office of the primary physician, or through community, governmental, public, and voluntary health care agencies and facilities. Although some patients with complex diagnostic problems and more severe impairment require consultative services or referral to specialized cardiac centers, all patients must eventually be returned to the care system and services of their local communities. (<i>JAMA</i>242:2879-2881, 1979)
Abstract 4636: Oncogenic Notch triggers neoplastic-tumorigenesis in a transition-zone like tissue microenvironment
Authors: Wu-Min Deng, Sheng-An Yang
Journal: Cancer Research (2019)

Abstract The “seed and soil” hypothesis proposed by Stephen Paget (1889) highlights the importance of tissue microenvironment for secondary tumor formation. The microenvironment that promotes primary tumor origination, however, remains largely unclear. Transition zones, where two types of epithelial tissue meet, have been characterized as high-risk sites for tumorigenesis. Here we show that the Drosophila salivary gland (SG) imaginal ring (ImR) can be used as a model to study tumorigenesis in transition zones. We found that constitutive activation of Notch signaling during the third larval instar drives overproliferation and tumor formation in the SG ImR. Interestingly, tumorigenesis always occurs at the posterior end of the ImR, which is a transitional area between the polyploid giant cells and diploid ImR cells. These Notch-induced tumors display disrupted epithelial organization, grow continuously and can metastasize once transplanted into the abdomen of adult flies, suggesting that they have the characteristics of malignant neoplasms. Further analyses revealed that the SG ImR transition zone possesses endogenously high levels of Janus kinase/signal transducers and activators of transcription (JAK-STAT) and c-Jun amino-terminal kinases (JNK), both of which are necessary for tumor growth. In this region, JNK signaling induces the expression of matrix metalloproteinase 1 (MMP1), which is also required for tumor formation in this model system. Furthermore, we found that ectopic MMP1 expression can transform the anterior end of the SG ImR, which is normally refractory to oncogenic Notch-induced tumorigenesis, into a tumor hotspot. Together, these studies reveal that local endogenous activation of JNK and JAK-STAT signaling creates a niche-like tissue microenvironment that is susceptible to oncogene-induced neoplastic tumor formation. Citation Format: Wu-Min Deng, Sheng-An Yang. Oncogenic Notch triggers neoplastic-tumorigenesis in a transition-zone like tissue microenvironment [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4636.
Highlights
Journal: JAMA (2018)

Physician burnout, characterized by emotional exhaustion, depersonalization, and a low sense of personal accomplishment, is associated with career dissatisfaction and early retirement.Dyrbye and colleagues surveyed 4696 second-year resident physicians and found that symptoms of burnout and career choice regret varied by clinical specialty.In an Editorial, Schwenk and Gold suggest that physicians reporting burnout are receiving recommendations for treatments before there is any real understanding of the "diagnosis."
Motor Vehicle Crash Injury Costs Topped $18 Billion in 2012
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Neuroblastoma. Newer chemical diagnostic tests
Authors: M. Bell
Journal: JAMA (1968)

Undoubtedly, one of the most striking advances in the diagnosis and treatment of tumors in children in the last ten years has been the association of the excretion of catecholamines and metabolites in urine with neuroblastoma. These investigations were initiated by the report of increased excretion of pressor amines by Mason and his co-workers<sup>12</sup>in 1957 followed by numerous reports in which a whole spectrum of metabolites was investigated (for summary, see Bell<sup>13</sup>). The materials of major interest in the diagnosis of neuroblastoma are illustrated in Fig 1, although in normal adrenal tissue, the pathway is extended beyond norepinephrine to epinephrine. In the majority of cases of neuroblastoma, the pathways noradrenaline to VMA and dopamine to HVA appear to be the most important, but in a minority, the transamination pathway from 4-hydroxy-3-methoxy-phenylalanine (HMPA) to 4-hydroxy-3-methoxyphenyl lactic acid (HMPLA) and HVA is of greater significance.<sup>14</sup> <h3>Problems of Differential</h3>
Reye's syndrome among patients with juvenile rheumatoid arthritis
Authors: K. M. Sullivan
Journal: JAMA (1988)

<h3>To the Editor.—</h3> I agree with Dr Schmidt's<sup>1</sup>comments on the technique for vasectomy in that ligation of the vas is far from being any guarantee of its permanent obliteration. I differ, however, in only fulgurating the urethral end of the vas. I then suture the sheath of the vas over the testicular end. Fulguration of the testicular end will lead to the likelihood of blowouts in the epididymis and this will decrease the success of later vasovasostomy. I consequently do not have a problem with there being a sperm granuloma near the site of the ligation, as long as the urethral end is satisfactorily fulgurated.
Clinical and hemodynamic stability in a patient with a large atrial septal defect; a 17-year follow-up
Authors: B. M. Beller
Journal: JAMA (1966)

THE EVALUATION for corrective surgery of patients with congenital heart disease is based to a large extent on the clinician's knowledge of what is considered to be the natural history of the disease. In the case of left-to-right shunts, a decision to repair a given defect is based upon the size of the lesion as estimated from the magnitude of the shunt flow and the level of the pulmonary artery pressure. In addition, factors other than hemodynamic ones, such as the frequency of occurrence of bacterial endocarditis and the technical difficulty of doing the surgery, must be considered. For atrial septal defect, the accumulated literature<sup>1-3</sup>provides ample evidence that the average life expectancy for a child with this lesion is reduced. It has been noted that the larger the shunt is, the more cardiac disability or an inoperable situation is likely to develop. However, medical centers which have a
Investigating hypertension.
Authors: P. W. Robertson
Journal: BMJ (1967)

underground workers.The helmet will only protect the head from injury if it is worn correctly and is designed to prevent those injuries which are foreseen.It must always be regarded as a second line of defence; accident prevention must be the primary aim.Mr. Jennett is in error when he states that V. S. Caviness's conclusions' were based solely on a study of first world war gunshot wounds.In the statement I quoted from reference was made to the work of W. F. Caveness,' who investigated 356 young adult males who sus- tained head injuries in the Korean war cam- paign.Of these, 159 had non-missile head injuries.The report deals with the occurrence
Epilepsy
Authors: Louis D. Boshes
Journal: JAMA (1969)

This monograph is a truly integrated study of the numerous aspects associated with the symptom of epilepsy. The authors, well-recognized as experts in convulsive disorders, intended this small but lucid account of their extensive clinical and laboratory studies as stimulus to the reader, be he student or specialist in neurology. And to the work and the experience of many others, they have added their own summaries and conclusions. Some 470 references indicate the important modern advances made in the understanding of epilepsy over the past 30 years. Presented are the data on the latest research in pharmacology, neurophysiology, and biochemistry, and even information on the newer concepts of surgery for the management of the intractable patient with seizures. The skillful integration and informative discussion of such data add to the value of the book. There are nine major areas to this book, including classification, causation, physiology, chemistry, diagnosis, therapy, and
Sex matters: secular and geographical trends in sex differences in coronary heart disease mortality
Journal: BMJ (2002)

Most doctors were against drinking any alcohol while on call (table), but 14% felt that social drinking was acceptable, and one fourth thought that in their specialty some alcohol use is safe.In response to asking how many drinks a doctor in their specialty could safely drink while on call, 94/129 (73%) answered 0, 12/129 (9%) answered 1, 5/129 (4%) answered 2, 6/129 (5%) answered 3, and 13/129 (10%) answered 4 or more.A quarter admitted to drinking alcohol while on call, and 64% and 27% reported having encountered colleagues whom they suspected had used or were impaired by alcohol while on call, respectively.Almost all doctors believed that patients care whether they use alcohol while on call, but doctors were divided about their obligation to inform patients before seeing them.Multivariable analysis showed that sex and specialty were not associated with doctors' responses.Older doctors, however, were more likely to report encountering doctors whom they suspected had used or were impaired by alcohol while on call.
SATIRE
Authors: R. B. Thompson
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction: Corrigendum: SMCHD1 mutations associated with a rare muscular dystrophy can also cause isolated arhinia and Bosma arhinia microphthalmia syndrome
Authors: Natalie D Shaw, Harrison Brand, Zachary A Kupchinsky, Hemant Bengani, Lacey Plummer, Takako I Jones, Serkan Erdin, Kathleen A Williamson, Joe Rainger, Alexei Stortchevoi, Kaitlin Samocha, Benjamin B Currall, Donncha S Dunican, Ryan L Collins, Jason R Willer, Angela Lek, Monkol Lek, Malik Nassan, Shahrin Pereira, Tammy Kammin, Diane Lucente, Alexandra Silva, Catarina M Seabra, Colby Chiang, Yu An, Morad Ansari, Jacqueline K Rainger, Shelagh Joss, Jill Clayton Smith, Margaret F Lippincott, Sylvia S Singh, Nirav Patel, Jenny W Jing, Jennifer R Law, Nalton Ferraro, Alain Verloes, Anita Rauch, Katharina Steindl, Markus Zweier, Ianina Scheer, Daisuke Sato, Nobuhiko Okamoto, Christina Jacobsen, Jeanie Tryggestad, Steven Chernausek, Lisa A Schimmenti, Benjamin Brasseur, Claudia Cesaretti, Jose E García-Ortiz, Tatiana Pineda Buitrago, Orlando Perez Silva, Jodi D Hoffman, Wolfgang Mühlbauer, Klaus W Ruprecht, Bart L Loeys, Masato Shino, Angela M Kaindl, Chie-Hee Cho, Cynthia C Morton, Richard R Meehan, Veronica van Heyningen, Eric C Liao, Ravikumar Balasubramanian, Janet E Hall, Stephanie B Seminara, Daniel Macarthur, Steven A Moore, Koh-ichiro Yoshiura, James F Gusella, Joseph A Marsh, John M Graham, Angela E Lin, Nicholas Katsanis, Peter L Jones, William F Crowley, Erica E Davis, David R FitzPatrick, Michael E Talkowski
Journal: Nature Genetics (2017)
The Hydrocephalus Association
Authors: J. Lorber
Journal: BMJ (1964)

BDICJOURNAL 755 in other cases due to the ulcerated nature of the surface of the tumour.We feel, therefore, that a biopsy is required for any cervix which has the clinical appearance of malig- nancy, despite an initial negative smear.As Professor McLaren has said, cervical smears from patients with irregular bleeding, in whom body cancer is suspect, are not in- frequently negative.We have found, however, that in such circumstances vaginal smears are frequently positive when a cervical scrape is negative, the exfoliated cells having been caught in the vaginal vault.When, therefore, body carcinoma is suspected, both cervical and vaginal smears should be examined before curettage.-Iam, etc.,
Detection and Comparison of DNA Adducts after in Vitro and in Vivo Diesel Emission Exposures
Authors: Jane Gallagher, Michael George, Michael Kohan, Claudia Thompson, Timothy Shank, Joellen Lewtas
Journal: Environmental Health Perspectives (1993)

Development of methods to evaluate certain classes of polycyclic aromatic compounds (PAC) detected in complex mixtures to which humans are exposed would greatly improve the diagnostic potential of 32P-postlabeling analysis. Identification of DNA adduct patterns or specific exposure-related marker adducts would strengthen associations between observed DNA adducts and exposures to different environmental pollutants (e.g., kerosene, cigarette smoke, coke oven, and diesel). We have compared diesel-modified DNA adduct patterns in various in vitro and in vivo rodent model systems and compared them to DNA reactive oxidative and reductive metabolites of 1-nitropyrene. The formation of nitrated polycyclic aromatic hydrocarbon (nitrated PAH) DNA adducts, derived from the metabolism of diesel extract constituents, was enhanced relative to other PAH-derived DNA adducts via xanthine oxidase-catalyzed nitroreduction. These adducts were detectable only by the butanol extraction version of the postlabeling analysis. Five major DNA adducts were detected in human lymphocytes treated in vitro with diesel extract. A major adduct detected in human lymphocytes treated in vitro with diesel extract comigrated with a major adduct detected in lymphocyte DNA treated with benzo[a]pyrene (BaP) alone. Other adducts that co-migrated with the major BaP-derived adducts were detected in skin and lung DNA isolated from rodents topically treated with (50 mg) diesel extract and the major adduct detected in calf thymus DNA treated with rat liver S9 and diesel particle extract. Postlabeling of lung DNA isolated from rodents exposed via lung inhalation for 24 months to diesel combustion emissions resulted in the formation of a major nuclease-P1-sensitive DNA adduct that did not co-migrate with the major BaP-diol epoxide adduct.(ABSTRACT TRUNCATED AT 250 WORDS)
Corrections to “Phase II trial of galiximab (anti-CD80 monoclonal antibody) plus rituximab (CALGB 50402): Follicular Lymphoma International Prognostic Index (FLIPI) score is predictive of upfront immunotherapy responsiveness”
Authors: M.S. Czuczman, J.P. Leonard, S. Jung, J.L. Johnson, E.D. Hsi, J.C. Byrd, B.D. Cheson
Journal: Annals of Oncology (2018)

Ann Oncol 2012; 23: 2356–2362 (doi:10.1093/annonc/mdr620) The following funding statement was missing from the original manuscript: ‘Supported by NIH grants U10CA180821 and U10CA180882 to the Alliance for Clinical Trials in Oncology.’ This has now been amended in the online version. Phase II trial of galiximab (anti-CD80 monoclonal antibody) plus rituximab (CALGB 50402): Follicular Lymphoma International Prognostic Index (FLIPI) score is predictive of upfront immunotherapy responsivenessAnnals of OncologyVol. 23Issue 9PreviewThis phase II CALGB trial evaluated the activity and safety of an extended induction schedule of galiximab (G) plus rituximab (R) in untreated follicular lymphoma (FL). Full-Text PDF Open Archive
International Conference on Inorganic and Nutritional Aspects of Cancer
Journal: JNCI Journal of the National Cancer Institute (1976)

Journal Article International Conference on Inorganic and Nutritional Aspects of Cancer Get access JNCI: Journal of the National Cancer Institute, Volume 57, Issue 2, August 1976, Page 459, https://doi.org/10.1093/jnci/57.2.459-b Published: 01 August 1976