tbuckley/cabot-search huggingface dataset:
Is Gallbladder Function a Predictor of Outcome?
Authors: David F. Ransohoff
Journal: Annals of Internal Medicine (1994)

Letters15 March 1994Is Gallbladder Function a Predictor of Outcome?David F. Ransohoff, MD and Willam A. Gracie, MDDavid F. Ransohoff, MDThe University of North Carolina at Chapel Hill; Chapel Hill, NC 27599-7105Ann Arbor, MI 48104Search for more papers by this author and Willam A. Gracie, MDThe University of North Carolina at Chapel Hill; Chapel Hill, NC 27599-7105Ann Arbor, MI 48104Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-120-6-199403150-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Few data exist as to whether the functional status of the gallbladder, as measured by opacification during oral cholecystography or by ultrasonography with cholecystokinin, predicts biliary problems in persons with asymptomatic gallstones. In recent reports of 5- to 8-year follow-up of 116 persons with silent gallstones in Rome [1] and of 10-year follow-up of 110 persons in Sirmione, Italy [2], gallbladder nonvisualization was not a predictor of subsequent biliary symptoms. However, the number of study patients was small. Nevertheless, even if the prognosis in such persons were more serious than for others with asymptomatic gallstones, it would probably ...References1. Attili AF, Capri R, Repice AM, Maselli J, The GREPCO Group. The natural history of gallstones: the GREPCO experience. In: Capocaccia L, Ricci G, Angelico F, Angelico M, Attili AF, Lalloni F, eds. Recent Advances in the Epidemiology and Prevention of Gallstone Disease. Dordrecht: Kluwer; 1991:47-50. Google Scholar2. Sama C, Morselli-Labate AM, Venturoli N, Puci A, Banterle C, Barbara L. The natural history of asymptomatic and symptomatic gallstones: 10 year follow-up in the Sirmione study (Abstract). Hepatology. 1992; 16:87A. Google Scholar3. Ransohoff DF, Gracie WA. Treatment of gallstones. Ann Intern Med. 1993; 119:606-19. Google Scholar Author, Article, and Disclosure InformationAffiliations: The University of North Carolina at Chapel Hill; Chapel Hill, NC 27599-7105Ann Arbor, MI 48104 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 March 1994Volume 120, Issue 6Page: 523-524KeywordsGallbladderUltrasound imaging ePublished: 15 August 2000 Issue Published: 15 March 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Ariana
Authors: Mona T. Lydon-Rochelle
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Annual Clinical Conference: Diagnosis and Treatment Strategies for Gynecologic Cancer
Journal: JNCI Journal of the National Cancer Institute (1985)

Annual Clinical Conference: Diagnosis and Treatment Strategies for Gynecologic Cancer Get access JNCI: Journal of the National Cancer Institute, Volume 74, Issue 6, June 1985, Page 1366, https://doi.org/10.1093/jnci/74.6.1366 Published: 01 June 1985
Pernicious Anemia, 18q Deletion Syndrome, and IgA Deficiency-Reply
Authors: Raphael B. Stricker
Journal: JAMA (1983)

<h3>In Reply.—</h3> We wish to thank Dr Hasen for pointing out an omission in our article, "Pernicious Anemia, 18q Deletion Syndrome, and IgA Deficiency." The following information lends further support to our original conclusions. 1. Anti-parietal cell antibody was present in our patient's serum. Antimicrosomal antibody (AMA) was also present in a titer of 1:400 (normal, &lt;1:100). Antithyroglobulin antibody (ATA) was negative by radioimmunoassay; however, these results were not available when our- report was drafted. Furthermore, our- patient had normal thyroid function study findings at the ages of 9 months, 10 years, and 14 years. Thus, the sudden onset of hypothyroidism at the age of 21 years associated with a positive AMA titer strongly suggests an "acquired" autoimmune syndrome. 2. In the cases cited by Dr Hasen,1,2 although ATA titers were negative, AMA determinations were not mentioned. Since as many as 25% of patients with autoimmune thyroid disease may have
The Manner of Man that Kills. Spencer—Czolgosz — Richeson.
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fibronectin in human bile fluid for diagnosis of malignant biliary diseases
Authors: T KORNER
Journal: Hepatology (1996)

In a preliminary study, we demonstrated a strong association between the concentration of the glycoprotein fibronectin (FN) in human bile fluid and the presence of malignant biliary diseases. We now present the results of measurements of total FN (tFN) and cellular FN (cFN) within a larger group of 71 patients. Bile fluid was collected during routine endoscopic retrograde cholangiography or by transhepatic puncture, respectively, from patients admitted for examination/treatment of biliary obstruction. Determination of tFN in bile was performed using a previously described time-resolved fluorescence immunoassay (TRFIA). For cFN, a newly developed TRFIA, using a specific monoclonal antibody for the EDA epitope of cFN, was applied. Within the noncarcinoma group of patients (n=50), consistently low concentrations of tFN (median = 5 ng/mL) were found. In most of these cases, the corresponding concentrations of cFN were below the detection limit (2.6 ng/mL) of this assay. Highly significantly elevated concentrations were found for both tFN (median = 1,220 ng/mL) and cFN (median = 243 ng/mL) in the carcinoma group (n = 21) in comparison with the noncarcinoma group (P < or = .01). By adopting cutoff values of 60 ng/mL for tFN and >0 ng/mL for cFN, diagnostic sensitivities for carcinoma of the biliary tract of 0.89 and 0.92, and specificities of 0.96 and 0.98, respectively, were computed. FN in bile fluid is suggested as a sensitive, specific, and easily determined marker for differential diagnosis of malignant and benign diseases of the biliary tract. (Hepatology 1996 Mar;23(3):423-8)
Avoiding Diabetes Self-management
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Immunoglobulin G lymphocytotoxic antibodies in clinical liver transplantation: Studies toward further defining their significance*1
Authors: R MAINEZ
Journal: Hepatology (1995)

Twenty-two consecutive liver allograft recipients, who tested positive for immunoglobulin G (IgG) lymphocytotoxicity were subjected to pretransplantion and posttransplantation immunologic monitoring of antidonor IgG lymphocytotoxic antibody titers, total hemolytic complement activity (CH100), circulating immune complexes (CIC), and platelet counts in an effort to improve our understanding of the preformed antibody state in clinical hepatic transplantation. Ten contemporaneous liver transplant recipients whose crossmatch results were negative and who experienced severe hepatocellular damage early after transplantation were included as controls. Crossmatch test results were negative 1 day after transplantation and during the 1 month follow-up remained negative in 14 of 22 (64%) sensitized recipients, most of whom had relatively low (≤1:16) antidonor IgG antibody titers before transplantation. After transplantation, this group and the control group experienced no thrombocytopenia, no increase of CIC, and a gradual increase in CH100 activity that reached normal levels within 1 week. A strong negative correlation between prothrombin time (PT) and CH100 activity in these groups of patients suggested that changes in CH100 activity (P < .0005) were tightly linked to liver synthetic function. In contrast, the crossmatch test results remained positive after transplantation in 8 of 22 (36%) sensitized recipients, all of whom had relatively high (>1: 32 to 1024) pretransplantation titers of anti-donor IgG antibodies. After transplantation these patients developed a syndrome that was characterized by decreased CH100 activity and increased CIC compared with pretrans plantation levels and refractory thrombocytopenia that was associated with a 50% allograft failure rate because of biopsy-proven humoral and acute (cellular) rejection. Moreover, the lack of a strong negative correlation between PT and CH100 activity (P = .1) in this group of patients suggested that the hypocomplementemia was not tightly linked to liver synthetic function. Before transplantation, determination of anti-donor antibody class (IgG) and titer alone showed a strong negative predictive value (100%) but less than optimal positive predictive value (67%) for identifying patients who experienced the posttransplantation syndrome described above. Therefore, evaluation of platelet counts, CH100 activity, CIC, persistence of anti-donor antibodies and results of a liver biopsy performed after transplantation assisted in identifying sensitized liver allograft recipients who suffered the adverse consequences of the preformed antibody state.
LASIX RENOGRAMS TO ENALUATE UPJ OBSTRUCTION.
Authors: Margaret Hackley, Teri Cupples, Stacey Russell
Journal: Clinical Nuclear Medicine (1983)

LSU Medical Center in Shreveport, Louisiana. This exhibit will consist of multiple cases of renal scintigraphy. Response to IV Lasix will be documented. Cases will have clinical correlations and current IVP's.
Patient Safety
Authors: Sanford E. Feldman
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Renal effects of dietary supplementation with fish oil in cyclosporine-treated liver transplant recipients*1, *2, *3
Authors: S BADALAMENTI
Journal: Hepatology (1995)

Nephrotoxicity is the main untoward effect of cyclosporine (CsA) treatment. Experimental and clinical data suggest that dietary supplementation with fish oil may lessen cyclosporine nephrotoxicity, possibly by lowering renal thromboxane (Tx) production. We have studied the renal effects of a daily supplementation for 2 months of 12 g fish oil (18% C20:5 n-3 eicosapentaenoic acid [Epa]and 12% C22:6 n-3 docosahexanoic acid [Dha]) in a placebo-controlled (12 g corn oil), prospective, randomized, double-blind study of stable CsAtreated liver transplant recipients. Thirteen patients ingested corn oil capsules and 13 fish oil. Compliance with dietary regimen was confirmed by fatty acid chromatography that showed increased plasma concentrations of EPA (from 0.4 ± 0.02% to 4.6 ± 0.5%, P < .0001) and DHA (from 1.8 ± 0.2% to 3.9 ± 0.1%, P < .0001) in the fish oil group and increased plasma concentration of linoleic acid (C18:2 n-6) in the corn oil group (from 25 ± 2% to 28.4 ± 2%, P < .001). At the end of the 2 months of the study, in the fish oil group the effective renal plasma flow increased by 22% (P = .012), the glomerular filtration rate increased by 33% (P = .057), the renal blood flow increased by 17% (P = .024), and the calculated total renal vascular resistances decreased by 20% (P = .034). In contrast, none of these parameters changed in the corn oil group. The renal functional reserve determined during l-arginine infusion, plasma renin activity (PRA), and plasma aldosterone (PA) remained unchanged during the study in either group. The urine excretion of Tx B2 decreased from 707 ± 192 to 276 ± 76 pg/hr (P = .013) in fish oil group, whereas it increased from 428 ± 195 to 870 ± 310 pg/hr (P = .016) in corn oil group. In conclusion, 2 months of diet supplementation with fish oil in stable CsA-treated liver transplant recipients was associated with significant improvement of renal hemodynamics and with significant reduction of the renal production of TxB2.
Massage and Exercise Combined.
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Smokeless tobacco use, birth weight, and gestational age: population based, prospective cohort study of 1217 women in Mumbai, India
Journal: BMJ (2010)

Objective To study the effect of using smokeless tobacco during pregnancy on babies' birth weight and gestational age at birth.Design Population based, prospective cohort study using a house to house approach.Setting Eight primary health post areas in the city of Mumbai (Bombay), India.Participants 1217 women who were three to seven months pregnant and planning to deliver in the study area.1167 women (96%) were followed up.Main outcome measures Birth weight and gestational age in singleton births.Results Smokeless tobacco use was associated with an average reduction of 105 g in birth weight (95% confidence interval 30 g to 181 g) and a reduction in gestational age of 6.2 (3.0 to 9.4) days.The odds ratio for low birth weight was 1.6 (1.1 to 2.4), adjusted by logistic regression for maternal age, education, socioeconomic status, weight, anaemia, antenatal care, and gestational age.The adjusted odds ratio for preterm delivery ( < 37 weeks) was 1.4 (1.0 to 2.1); for delivery before 32 weeks it was 4.9 (2.1 to 11.8) and before 28 weeks it was 8.0 (2.6 to 27.2).Conclusions Consumption of smokeless tobacco during pregnancy decreases gestational age at birth and birth weight independent of gestational age.It should receive specific attention as a part of routine prenatal care.
Correlation of bone marrow micrometastases with nodal status in gastrointestinal tumors
Authors: S. Chivu, S. Saha, G. M. Patel, D. Wiese, N. Bassily, A. Henke, H. Sankaran, A. Misra, T. Singh, M. Arora
Journal: Journal of Clinical Oncology (2007)

14577 Background: Presence of bone marrow micrometastases (BMM) is an important prognostic factor for patients (pts) with solid tumors. Sentinel lymph node (SLN) mapping (M) has been found to upstage pts with gastrointestinal (GI) malignancies. However, a direct correlation between the presence BMM and nodal metastases (mets) is lacking. Hence, a retrospective study was undertaken to determine the relationship between BMM and nodal status in various GI malignancies. Methods: A total of 159 consecutive pts with GI malignancies were analyzed. Of these, 6 pts with non-epithelial tumors were excluded. All pts underwent bilateral posterior-superior-iliac spine bone marrow (BM) aspiration. BM samples were examined for micrometastases by Automated Cellular Imaging System using ChromaVision Cytokeratin Detection Kit to detect cells expressing CK8 as defined by CAM 5.2 monoclonal antibody. When feasible, SLNM was performed followed by standard oncologic resection (n=105). The SLN were examined by H&amp;E and immunohistochemical (IHC) staining. Results: A total of 153 pts were analyzed in the study. Of these 13.72% (21/153) were found to have BMM (CI 8.70–20.21, p=0.05). When analyzed by sites, the incidence of BMM was 33.3% (4/12) for stomach cancer, 9.1% (1/11) for pancreatic cancer, 12.36% (11/89) for colon cancer and 16.13% (5/31) for rectal cancer. No BMM were detected in pts with cancer of esophagus (n=7), small bowel (n=2) and liver (n=1). The BMM was positive bilaterally in 61.9% (13/21), and unilaterally in 38.1% (8/21). In pts who underwent SLNM (n=105), BMM were detected in 11.11% of SLN positive pts vs. 10.14% for SLN negative pts (p=0.87). For a subgroup of pts with colorectal cancer who underwent SLNM (n=97), BMM were detected in 9.67% of SLN positive pts vs. 9.09% for SLN negative pts (p=0.92) Conclusions: BMM did not correlate with nodal status for GI malignancies suggesting a possible different mechanism for metastases. Detection of BMM may have a significant clinical value in SLN negative pts who may benefit from adjuvant therapy. [Table: see text] No significant financial relationships to disclose.
Fluoroscopically guided percutaneous bone biopsy
Authors: G. F. Carrera
Journal: JAMA (1981)

FLUOROSCOPICALLY guided percutaneous needle biopsy is a safe and reliable method for obtaining cytological or histological specimens from bone lesions. Adequate needle biopsy obviates the need for general anesthesia or extensive open-biopsy procedures in debilitated patients and improves planning for further diagnosis and therapy. Percutaneous needle biopsy under fluoroscopic guidance has become an important technique in our institution for evaluating accessible skeletal lesions. <h3>Materials and Methods</h3> A comprehensive review of percutaneous needle bone biopsy was presented by de Santos et al<sup>1</sup>in 1978. The biopsy site is chosen after reviewing preliminary studies, such as roentgenograms, tomograms, radioisotope bone scans, and computed tomograms. The approach to the lesion is dictated by local anatomy, such as major blood vessels, nerves, or the pleural space. If multiple lesions are present, a specific lesion that allows both good fluoroscopic visualization and a safe approach is selected for biopsy. A lytic lesion, or a
A Course of Elementary Practical Bacteriology, including Bacteriologic Analysis and Chemistry.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal