tbuckley/cabot-search huggingface dataset:
Questions and Answers
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prophylaxis in rubella.
Journal: BMJ (1967)

PointersIntrauterine Transfusion: Workers in Newcastle concluded from their studies that in spite of the hazard this procedure has an important role in the management of some cases of Rh-haemo- lytic disease (p.189).Transepidermal Water Loss: Is greatly in- creased in patients with erythroderma, psoriasis, and ichthyosis compared with normal subjects.This may explain the hypothermia and increased B.M.R. found in some of these patients (p.195).Emergency Intracardiac Pacemaking: Discussion of bedside method of placement using intracavitary electrocardiogram picked up by pacemaker electrode as a guide in patients with Adams-Stokes attacks (p.199).Oxygen Therapy: In paediatric use knowledge of exact concentration of oxygen is important.Studies show that incubators generally fulfil manufacturers' specifications, and that the Oxygenaire Humidaire Tent was the most effi- cient of the tents tested (p.201).Colitis in India: Ulcerative variety is not rare, but diagnosed less often than in the West because of the frequency of infectious conditions of the bowel, lack of facilities for precise diag- nosis, and lack of long-term follow-up (p.204).Congenital Cyanotic Heart Disease: Retinal vascular changes initially present revert to normal after surgical correction of cardiac lesion, but E.E.G. defects do not change because they are not due to simple cerebrovascular disturb- ance (p.207).Electrophoretic Studies and Cancer: Study of .survival of radioiodine-labelled serum yG- globulin showed that the different fractions broke down at different rates, and were different in a patient with cancer from a normal subject (p.210).Case Reports: Enzyme variant in congenital methaemoglobinaemia (p.212); Anaphylactic reaction after soap enema (p.215) ; Fatality after phenformin overdose (p.216) ; New wave in E.C.G. complex (p.217).Conferences: Chemotherapy of tuberculosis in developing countries (p.230).European Asso- ciation for Study of the Liver (p.232).Dyspepsia: Symptoms, diagnosis, and manage- ment of gastro-oesophageal reflux due to hiatus hernia (p.218).Clinicopathological Conference: Crohn's dis- ease in patient with treated adult coeliac disease (p.222).
Quadriceps Strength and Osteoarthritis Progression in Malaligned and Lax Knees
Authors: David Riley
Journal: Annals of Internal Medicine (2004)

Letters20 January 2004Quadriceps Strength and Osteoarthritis Progression in Malaligned and Lax KneesDavid Riley, MDDavid Riley, MDFrom University of New Mexico, Santa Fe, NM 87502.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-140-2-200401200-00028 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:It should come as no surprise that, as Sharma and colleagues report (1), isolated strengthening of the quadriceps is unlikely to help persons with osteoarthritis. An open joint space is contingent on alignment as determined not only by the quadriceps muscle above and in the front but by the hamstrings behind, the abductors and adductors, and the muscles of the lower leg below. In addition, the balance between strength and flexibility is probably more important than strength alone, and integrating alignment with flexibility and strength is essential in patients with osteoarthritis.References1. Sharma L, Dunlop DD, Cahue S, Song J, Hayes KW. Quadriceps strength and osteoarthritis progression in malaligned and lax knees. Ann Intern Med. 2003;138:613-9. [PMID: 12693882] LinkGoogle Scholar Author, Article, and Disclosure InformationAuthors: David Riley, MDAffiliations: From University of New Mexico, Santa Fe, NM 87502. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoQuadriceps Strength and Osteoarthritis Progression in Malaligned and Lax Knees Leena Sharma , Dorothy D. Dunlop , September Cahue , Jing Song , and Karen W. Hayes Quadriceps Strength and Osteoarthritis Progression in Malaligned and Lax Knees Leena Sharma , Dorothy D. Dunlop , and Karen W. Hayes Is a Strong Quadriceps Muscle Bad for a Patient with Knee Osteoarthritis? Leena Sharma , Dorothy D. Dunlop , and Karen W. Hayes Quadriceps Strength and Osteoarthritis Progression in Malaligned and Lax Knees James Judge Quadriceps Strength and Osteoarthritis Progression in Malaligned and Lax Knees Mary E. Moore Metrics Cited byThe effect of exercise therapy on knee adduction moment in individuals with knee osteoarthritis: A systematic review 20 January 2004Volume 140, Issue 2Page: 149KeywordsKneesMusclesOsteoarthritis ePublished: 20 January 2004 Issue Published: 20 January 2004 Copyright & PermissionsCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Incorrect Prevalence
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Board of Trustees
Journal: JAMA (1979)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Amended 95% Confidence Intervals in Tables in the Article by Jani et al (Arthritis Rheumatol, August 2015)
Journal: Arthritis & Rheumatology (2015)

Dr. Scarpa makes an important point with regard to my editorial.As mentioned in the editorial, the new definition of peripheral SpA is not particularly helpful for diagnosis or classification of patients with psoriatic arthritis.Dr. Scarpa suggests that perhaps psoriatic arthritis should be considered a separate entity, "psoriatic disease," because of its clinical picture, its evolving pathogenesis, and its treatment.He may very well be correct.Even within the Assessment of SpondyloArthritis international Society, psoriatic arthritis is considered a separate disease, and indeed, in the study discussed in my editorial, the investigators actually excluded patients with psoriatic arthritis (Mease P, Sieper J, van den Bosch F, Rahman P, Karunaratne PM, Pangan AL.Randomized controlled trial of adalimumab in patients with
Ruptured Klebsiella pneumoniae liver abscess after high‐dose cyclophosphamide for severe aplastic anemia
Authors: Je‐Jung Lee, Hyeoung‐Joon Kim, Ik‐Joo Chung, Hoon Kook, Moo‐Rim Park, Chan‐Jong Kim, Dong‐Hyeon Shin, Tai‐Ju Hwang
Journal: American Journal of Hematology (2000)

A 19-year-old woman with severe aplastic anemia who had previously failed antithymocyte globulin/cyclosporine A received high-dose cyclophosphamide without bone marrow rescue. On day +14, she complained of right upper quadrant abdominal pain and fever. A CT scan of the abdomen showed multiple liver abscesses with rupture and Klebsiella pneumoniae was isolated from blood. In spite of aggressive antibiotic therapy, she rapidly deteriorated and died of overwhelming sepsis. To our knowledge, our patient is the first case of fatal ruptured liver abscess after high-dose cyclophosphamide in a patient with severe aplastic anemia. Am. J. Hematol. 64:218–220, 2000. © 2000 Wiley-Liss, Inc.
Spreading US Macrolide Resistance
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Chronic Hepatic Encephalopathy
Authors: Herbert Freund
Journal: JAMA (1979)

Therapy of chronic hepatic encephalopathy is often frustrating, limited as it is by the ability to adequately nourish such patients. Protein is needed for repair, but such patients are intolerant of protein. Previous work from this and other laboratories has suggested that the distorted plasma amino acid pattern may be causally related to hepatic encephalopathy. A single, well-studied, long-term patient received therapy with a branched-chain amino-acid—enriched elemental diet that not only enabled adequate nutrition with protein but resulted in improvement in hepatic function as well as reversal of some aspects of hepatic encephalopathy that heretofore have been deemed irreversible. The results confirm that branched-chain—enriched amino acid diets previously successful in the intravenous mode may be successfully used in chronic long-term support of patients with protein intolerance, with improvement in hepatic function secondary to improvement in nutrition. (<i>JAMA</i>242:347-349, 1979)
Abstract 1201: Lack of Dehydroepiandrosterone-sulfate (DHEAS) contributes to CD4 T Cell-Induced Endothelial Apoptosis in Perimenopausal Women
Authors: Yuki Suzuki, Kayoko Sato, Keiko Gomita, Toshiaki Nuki, Nobuhisa Hagiwara, Hiroshi Kasanuki
Journal: Circulation (2007)

Background: Postmenopausal women develop atherosclerosis faster and have higher incidence of acute coronary syndromes. Endogenous dehydroepiandrosterone-sulfate (DHEAS) is a major source of estrogen for women after menopause. Low levels of DHEAS is also a known risk factor for coronary atherosclerotic disease in men. However, the causal relationship between DHEAS levels in women and acute coronary syndromes (ACS) is not fully understood. In this study, we examined whether CD4 T cells from perimenopausal women (PMW) with low levels of DHEAS induce endothelial apoptosis that is prone to develop plaque erosion. Methods and Results: Fresh CD4 T cells were isolated from 45 PMW within 5 years after menopause (mean age 53.9 ± 6.0 years) and from 40 women with regular menstruation cycles (NC, mean age 34.0 ± 7.4 years). DHEAS levels in plasma by ELISA correlated negatively with age (R = 0.500, P &lt; 0.02). DHEAS was lower in PMW than in NC (P &lt; 0.0001). Estrogen receptor α (ESR1) and estrogen receptor β (ESR2) mRNA of CD4 T cells in PMW were lower compared to NC by real time PCR (P &lt; 0.05). DHEAS levels correlated significantly with ESR2 transcripts (R = 0.789, P &lt; 0.0001), but not with ESR1. Measurement of fragmentation of DAPI-binding nuclear proteins showed that CD4 T cells from PMW induce significant human umbilical vein endothelial cells (HUVEC) apoptosis compared to those from NC (P&lt;0.0001). DHEAS levels correlated negatively with CD4 T cell-induced HUVEC apoptosis (R = 0.499, P &lt; 0.02). Treatment with 17β-estradiol showed reduction of CD4 T cell-induced apoptosis in PMW. Pure estrogen receptor antagonist ICI 172,780 abolished estrogen protection. Conclusions: Our results showed that the aging marker of DHEAS was lower in perimenopausal women, and that the low levels DHEAS, a endogenous major source of estrogen after menopause, induced CD4 T cell-induced endothelial apoptosis may be associated with ESR2. We concluded that low levels of DHEAS in perimenopausal women can be one factor that contributes to the acceleration of plaque erosion in atherosclerotic plaque and acute coronary syndromes.
Seizure after infusion of aminocaproic acid
Authors: S. E. Feffer
Journal: JAMA (1978)

AMINOCAPROIC acid is a useful agent in the management of hemophilia, particularly following extensive dental manipulations. The drug is widely used, in large measure because toxic reactions, including gastrointenstinal disturbances, dizziness, tinnitus, malaise, headache, rash, and conjunctival and nasal suffusion, are mild and rarely encountered. We report the case of a patient who experienced several of these side effects after aminocaproic acid infusion, then promptly progressed to a grand mal seizure, a toxic reaction not previously described. <h3>Report of a Case</h3> A 32-year-old man with mild hemophilia (factor VIII levels ranging from 10% to 15%) was admitted for dental scaling and prophylaxis. The patient's hemophilia had been identified two years prior to this admission, when he had bled excessively after dental extraction. At that time, von Willebrand's disease had been excluded by a normal bleeding time and ristocetin aggregation study. He had a long history of dental problems and had
Benefits from aortocoronary bypass graft
Authors: H. D. McIntosh
Journal: JAMA (1978)

The first aortocoronary bypass graft (ACBG) for coronary heart disease (CHD) was performed in 1964. From 1967 to the summer of 1977, between 250,000 and 300,000 such procedures were performed in this country. With such extensive experience, the patient might expect that most questions regarding the effectiveness of the procedure in the treatment of CHD would have been answered. Unfortunately, this is not the case. After a decade of experience, all that is truly known about the procedure is that for most patients, it does improve the quality of life and, if present practices continue, will add greatly to the cost of medical care in this country. It appears that there is still a need for more randomized, controlled studies. (<i>JAMA</i>239:1197-1199, 1978)
Correction.
Authors: Chas. J. Douglas
Journal: JAMA (1900)

Boston, Mass., Dec. 3, 1900. <h3>To the Editor:</h3> —In the abstract department in your issue of December 1, on page 1432, you say that in delirium tremens I recommend "the gradual withdrawal of alcohol and nourishment." As I have earnestly insisted upon the great value of nutrition in this disease, the statement that I advise the "gradual withdrawal of nourishment"—presumably to the point of total abstinence—is startling, to say the least. Whether the error is typographical or a slip of the pen is not clear, but, doubtless, what you meant to say was that I prescribe nourishment, accompanied by the gradual withdrawal of alcohol. [The unfortunate omission of a comma after the word "alcohol" is the cause of the ambiguous reading to which our correspondent objects.—Ed.]
A Report on the Physiological Action of Chloroform, with a Criticism of the Second Hyderabad Chloroform Commission
Authors: W. H. Gaskell, L. E. Shore
Journal: BMJ (1893)

FEBd 4, 189. no precautions should be thrown aside in carrying out these processes.1 this ts well done the observer need not seek far for stains if he wishes simply to see the parasite.A perfect diffetential stain to pick out the bodies alone is still to be found.The nuclear stains, such as methyl green htematoxylin, are not very suitable for that purpose; like the cocciAia in the rabbit's liver, the parasite seems to prefer general proto- plasmio stains, and, acting on this principle, the best results of which I am aware have been obtained by Mr. Plimmer, who has used aniline blue as the special stain for the organism.
Our Hospitals
Authors: E. M. Arbuthnot
Journal: BMJ (1960)

<h3>Abstract</h3> <h3>Background</h3> HAS (Human Serum Albumin) is a highly water-soluble globular plasma protein, with a relative molecular weight (g/mol) of 67 KDa, consisting of 585 amino acid residues. In this study, we have investigated the interaction of the Crystal structures complexed in human serum albumin at resolutions of 2.8 to 2.0: Camptothecin, 9-amino-camptothecin, Etoposide, Teniposide, Bicalutamide and Idarubicin, using a bioinformatic approach, estimated by Pyrx Virtual Screen Tool and AMDock (AMDock, Assisted Molecular Docking). We have analyzed a validated protocol, studying several parameters, as Binding Affinity, RMSD value, Ligand Efficiency, and Inhibition constant (Ki value). <h3>Methods</h3> Human Serum Albumin protein preparation was characterized with several programs, as Chimera, MGLTools 1.5.6, Swiss PDB Viewer Software to perform docking analysis by Autodock Vina estimated with Pyrx Software. <h3>Results</h3> In this work, we have found crystalized camptothecin, crystalized 9-amino-camptothecin and crystalized teniposide, gave excellent results for Binding Affinity, (kcal/mol), RMSD value (A°), inhibition constant Ki value (nM): -Binding Affinity of 9-amino-camptothecin (ca.−10 kcal/mol), camptothecin (−9 kcal/mol) and teniposide (−11 kcal/mol, -RMSD Value of 9 -amino-camptothecin (ca.1.8 Å), camptothecin (ca.2.2 Å) and teniposide (ca. 3.6 Å), - Ki Value: 9 -amino-camptothecin (ca 59 nM), camptothecin (ca 183 nM) and teniposide (ca 9 nM), -Ligand efficiency: of 9 -amino-camptothecin(ca −0.35 kcal/mol), camptothecin (ca −0.34 kcal/mol) and teniposide (ca −0.24 kcal/mol <h3>Conclusions</h3> We explored the best three crystallized ligand in Human Serum Albumin. Moreover, we observe a complete overlap, during the re-docking analysis phase, estimated by chimera Software. Therefore we have concluded that ID PDB Crystal 4L8U human serum albumin-Crystallised 9 -amino Camptothecin; ID PDB Crystal 4L9K human serum albumin-Crystallised Camptothecin and ID PDB Crystal 4L9Q human serum albumin-crystallized teniposide be used as a possible as a reference template protein to be compared with the target protein, by Docking molecular analysis.
Journal Club
Journal: Arthritis & Rheumatology (2021)

exposures and RA-related factors while stratifying the data by SE status and adjusting for age, sex, race, and tobacco use.The researchers received responses from 797 of 1,566 participants; compared with nonrespondents, the study population was older, more often White or male, less frequently smokers, and had lower disease activity.Among participants who were positive for SE alleles, burn pit exposure and military waste exposure were more strongly associated with anti-CCP positivity than nonexposure.The authors conclude that the fi ndings are consistent with emerging evidence that various inhalant exposures infl uence autoantibody expression and RA risk.
Allergy to foods in patients monosensitized to <i>Artemisia</i> pollen
Authors: J. C. García Ortiz, P. Cosmes Martin, A. Lopez‐Asunsolo
Journal: Allergy (1996)

It is known that patients with pollinosis may display clinical characteristics caused by allergy to certain fruits and vegetables, but subjects allergic to Artemisias seem to show particularly peculiar characteristics. The clinical features of 84 patients with rhinitis, asthma, urticaria, and/or anaphylaxis whose inhalant allergy was exclusively to Artemisia vulgaris were studied and compared with a control group of 50 patients monosensitized to grass pollen. The mean age for the beginning of symptoms was 30.2 years, and this was higher than in the control group ( P &lt; 0.05). We found the main incidence to be in women (70.2%). Some 42.3% had family history of atopia, lower than in the control group ( P &lt; 0.05), while the prevalence of asthma and urticaria was significantly higher ( P &lt; 0.05). Food hypersensitivity was reported by 23 patients (27.3%) allergic to Artemisia . The foods responsible (with respective numbers of cases) were honey (14), sunflower seeds (11), camomile (four), pistachio (three), hazelnut (two), lettuce (two), pollen (two), beer (two), almond (one), peanut (one), other nuts (one), carrot (one), and apple (one). None of the patients monosensitized to grass had food allergy. CAP inhibition experiments were carried out on a single patient. Results showed the existence of common antigenic epitopes in pistachio and Artemisia pollen for this patient. We concluded that mugwort hay fever can be associated with the Compositae family of foods, but that it is not normally associated with other foods.
Plain language summaries
Journal: British Journal of Dermatology (2016)

Linked Article: Lima et al. Br J Dermatol 2016; 174: 514–521. Linked Article: Wedgeworth et al. Br J Dermatol 2016; 174: 594–601. Linked Article: Zhong et al. Br J Dermatol 2016; 174: 542–552. Linked Article: Guida et al. Br J Dermatol 2016; 174: 610–616. Linked Article: Taylor-Robinson et al. Br J Dermatol 2016; 174: 569–578. Linked Article: de Vries et al. Br J Dermatol 2016; 174: 588–593. Linked Article: Geale et al. Br J Dermatol 2016; 174: 579–587.