tbuckley/cabot-search huggingface dataset:
PTU-025 A new paradigm in the non-invasive assessment of portal hypertension: a single ultrasound procedure incorporating acoustic radiation force impulse (ARFI) elastography predicts over 90% of oesophago-gastric varices and portal gastropathy
Authors: D I Sherman, K Kandiah, M Jagtiani, A Sharif, P Bassett, P Shorvon
Journal: Gut (2012)

<h3>Introduction</h3> Accurate non-invasive techniques for imaging portal hypertension (PHT) have long been the goal of hepatologists. However the sensitivity of standard ultrasound (US) alone is too low to achieve this. The combined use of elastography with US to detect PHT has not been investigated. ARFI (Virtual Touch<sup>©</sup>) elastography is a novel validated technique for measuring liver stiffness (LS), with practical advantages over transient elastography including real-time scanning. We report our experience of this technique in assessing PHT in a consecutive secondary care cohort. <h3>Aims</h3> To establish whether the addition of LS estimation by ARFI to conventional US Doppler assessment of the spleno-portal venous system can reliably predict the presence of significant endoscopic PHT. <h3>Methods</h3> Conventional US and elastography were performed simultaneously at one session by a single radiologist, using a Siemens Acuson S2000<sup>TM</sup> and 4C1 probe 4 MHz transducer and a standard, validated 10 observation right lobe ARFI technique. Within the study period, 82/108 chronic liver disease (CLD) patients (60 hospitalised and 48 outpatients) underwent both elastography and upper GI endoscopy. Standard US data collected included spleen size, portal vein Doppler flow velocity, direction and waveform, presence of collaterals, and platelet count. <h3>Results</h3> Significant endoscopic PHT, defined as oesophageal/gastric varices and/or moderate to severe portal hypertensive gastropathy, was seen in 34/82 patients (41%). Median LS measured by shear velocity was significantly higher in the PHT group (2.9 vs 2.2 m/s, p&lt;0.001). A 10 point “SPVD” (spleen-platelets/portal vein Doppler) scoring system, devised to include all US parameters and platelet count, showed significantly higher median scores in PHT (3 vs 1, p&lt;0.001). Multiple logistic regression analysis demonstrated that both ARFI and SPVD score were independent predictors of PHT (OR, 95% CI 2.73, 1.22 to 6.13, p=0.02; and 3.08, 1.89 to 5.02, p&lt;0.001, respectively). AUROC analysis showed that a best fit combination of ARFI+SPVD score showed the highest overall predictive value at 0.91, compared with ARFI or SPVD alone (0.72 and 0.87, respectively). <h3>Conclusion</h3> In this retrospective “real world” study the addition of ARFI to standard US parameters using a combined scoring system achieved high (&gt;90%) predictive value for the non-invasive detection of endoscopic PHT. A further prospective study, with refinement of US Doppler technique, is now in progress to confirm these promising results. Single session ARFI+US may accurately guide PHT diagnosis and selection for endoscopic surveillance in CLD. <h3>Competing interests</h3> None declared.
Cristina
Authors: Peggy Hansen
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Multiple sclerosis
Authors: David A. Hafler
Journal: Journal of Clinical Investigation (2004)

Multiple sclerosis is a complex genetic disease associated with inflammation in the CNS white matter thought to be mediated by autoreactive T cells. Clonal expansion of B cells, their antibody products, and T cells, hallmarks of inflammation in the CNS, are found in MS. This review discusses new methods to define the molecular pathology of human disease with high-throughput examination of germline DNA haplotypes, RNA expression, and protein structures that will allow the generation of a new series of hypotheses that can be tested to develop better understanding of and therapies for this disease.
Knowledge About Causes of Peptic Ulcer Disease—United States, March-April 1997
Journal: JAMA (1997)

An estimated 25 million persons in the United States have had peptic ulcer disease (PUD) during their lifetimes. A high proportion (at least 90%) of PUD cases are caused by infection with Helicobacter pylori-an association first reported in 1983. However, in 1995, most (72%) of the general public was unaware of this association. To increase awareness among the general public and health-care providers about the relation between H. pylori infection and PUD, CDC, in collaboration with other federal agencies, academic institutions, and partners from private industry, has developed an awareness and education campaign. The campaign is being initiated during October 19-25, 1997, in conjunction with National Infection Control Week. In preparation for the education campaign, during early 1997 a population-based survey was conducted to provide more current estimates of knowledge about the causes of PUD. This report summarizes the survey findings and describes the campaign; the findings indicate that only 27% of the general public is aware of the association between H. pylori infection and PUD.
Abstract 1506: Lymph node metastasis in clinical breast cancer is significantly promoted by myeloid-derived lymphatic endothelial cell progenitors
Authors: Lisa D. Volk-Draper, Radhika Patel, Nihit Bhattarai, Jie Yang, Sophia Ran
Journal: Cancer Research (2019)

Abstract Introduction: Lymph node (LN) metastasis, a key prognostic factor for poor survival of breast cancer (BC) patients, directly depends on tumor lymphangiogenesis. We previously showed in orthotopic BC models that lymphangiogenesis is strongly promoted by tumor-mobilized myeloid-derived lymphatic endothelial cell (LEC) progenitors (M-LECP) and that M-LECP density correlates with lymphatic metastasis. The goals of this study were to determine the blood levels of M-LECP, their tumor density and correlation with metastasis in clinical human BC. Methods: Circulating CD14+ cells from BC patients (N=25) and healthy donors (N=24) were analyzed for expression of lymphatic-specific markers. Specimens from BC patients (N=104) along with normal mammary tissues (N=6) were co-stained with antibodies against myeloid and lymphatic markers including CD68, CD14, CD18 as well as LYVE1, podoplanin, and VEGFR-3. Sections were also double-stained to identify LYVE1+ cells expressing lymphoid, M2-type macrophage, and stem cell markers. Densities of tumor CD68+ macrophages, LYVE1+ vessels, and CD68+/LYVE1+ double-stained M-LECP were quantified and correlated with node status and other parameters. Pro-metastatic potential of experimentally produced mouse M-LECP was determined by injecting in vitro differentiated myeloid-lymphatic cells into mice bearing syngeneic EMT6 breast tumors. Results: 92% of BC patients had monocytes expressing at least one lymphatic marker compared 2% of healthy donors. More than 70% of breast tumors contained M-LECP with density ranging from 2 to 50 cells per high-power field. Tumor-recruited M-LECP express specific markers of myeloid but not lymphoid lineages as well as M2-type, and stem cell markers. Tumors with high density (&amp;gt;20 cells/field) of M-LECP were significantly more likely to belong to aggressive sub-groups (HER2+ and TNBC) and present with lymph node metastasis (P-value &amp;lt;0.02). Conclusion: These data show for the first time that human breast tumors recruit significant amount of immature myeloid cells with lymphatic phenotype and vessel-promoting properties. Such cells are largely absent from normal breast tissues. Statistical analyses show that M-LECP can significantly contribute to formation of new lymphatic vessels leading to increased nodal metastasis. Citation Format: Lisa D. Volk-Draper, Radhika Patel, Nihit Bhattarai, Jie Yang, Sophia Ran. Lymph node metastasis in clinical breast cancer is significantly promoted by myeloid-derived lymphatic endothelial cell progenitors [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1506.
Evaluating Industry Payments Among Dermatology Clinical Practice Guideline Authors—Reply
Authors: Jake Xavier Checketts, Matt Vassar
Journal: JAMA Dermatology (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Abstract 5178: Genomic and transcriptomic alterations of chromatin factors in head and neck cancer
Authors: Hui Cheng, Riyue Bao, Carter Van Waes, Vassiliki Saloura
Journal: Cancer Research (2019)

Abstract Chromatin factors play central roles in the transcriptional regulation and maintenance of genomic stability and have been implicated in cancer initiation and progression in multiple cancer types. No study has systematically investigated the genomic and expression alterations of chromatin factors in head and neck squamous cell carcinoma (HNSCC). To this purpose, we utilized the molecular profiles from over 510 HNSCCs in the Cancer Genome Atlas (TCGA), and thoroughly characterized the mutational, copy number and transcriptional alterations of 457 chromatin factors and histones. Over 75% of all HNSCC samples have genomic alterations in protein methyltransferases and protein demethylases. Protein lysine methyltransferases MLL2 and NSD1 are the most frequently mutated chromatin factors in this disease. Actin Like 6A (ACTL6A), a component of the SWI/SNF chromatin remodeling complex, SUMO specific peptidase 5 (SENP5) and Nuclear receptor binding SET domain protein 3 (NSD3) are the most frequently copy-number amplified and overexpressed chromatin factors. Interestingly, hierarchical clustering of gene expression of a set of chromatin factors identified a molecular subtype with significantly better overall survival (OS), regardless of HPV-status, stage and NSD1 mutation status, a factor recently reported to render better OS in HNSCC. Systematic characterization of the deregulation of chromatin factors may elucidate novel epigenetic mechanisms and provide novel targets for cancer therapy in HNSCC. Supported by NIDCD intramural projects ZIA-DC-000016, 73 and 74. Note: This abstract was not presented at the meeting. Citation Format: Hui Cheng, Riyue Bao, Carter Van Waes, Vassiliki Saloura. Genomic and transcriptomic alterations of chromatin factors in head and neck cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 5178.
The Propaganda for Reform
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
On the horns
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Implantable venous access devices.
Authors: Alison Metcalfe, J Baum
Journal: BMJ (1991)

suffer from greater underascertainment than we estimated the incidence of childhood diabetes would be correspondingly increased throughout the British Isles, indicating an even greater dif- ference between the incidence in 1988 compared with that reported by Bloom et al for 1973-4.2The cause for public concern remains: urgency is added to the case for further national studies such as ours and multinational studies such as EURODIAB.
The spleen: Neglected but essential
Authors: Pierre Buffet
Journal: HemaSphere (2018)

Paris Descartes University, Paris, France This is an open access Abstract Book distributed under the Attribution-NonCommercial-NoDerivs (CCBY-NC-ND), which allows third parties to download the abstracts and share them with others as long as they credit the author and the abstract book, but they cannot change the content in any way or use them commercially. http://creativecommons.org/licenses/by-nc-nd/4.0
THE IMMIGRANT SHIPS AND OTHER POINTS OF MARINE HYGIENE.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction
Journal: BMJ (1962)

when possible.The local reaction might or might not recur after a full dose of antitoxin.and if it did the chance that it might be more severe, considering the balance of risks, than an attack of tetanus must be taken into account.It is recommended' that if there is no general reaction to a test-dose of antitoxin the full dose may be given, say, within half an hour.This may involve the risk of a variable amount of serum sickness, which is uncomfortable but not serious, and this must be weighed against the possibility of tetanus.
Three-Dimensional Visualization of Physiologically Based Kinetic Model Outputs
Authors: John Nichols, Penny Rheingans, Douglas Lothenbach, Robert McGeachie, Loren Skow, James McKim
Journal: Environmental Health Perspectives (1994)

Outputs from a physiologically based toxicokinetic (PB-TK) model for fish were visualized by mapping time-series data for specific tissues onto a three-dimensional representation of a rainbow trout. The trout representation was generated in stepwise fashion: 1) cross-section images were obtained from an anesthetized fish using a magnetic resonance imaging system, 2) images were processed to classify tissue types and eliminate unnecessary detail. 3) processed images were imported to a visualization software package (Application Visualization System) to create a three-dimensional representation of the fish, encapsulating five volumes corresponding to the liver, kidney, muscle, gastrointestinal tract, and fat, Kinetic data for the disposition of pentachloroethane in trout were generated using a PB-TK model. Model outputs were mapped onto corresponding tissues volumes, representing chemical concentration as color intensity. The workstation software was then used to animate the images, illustration the accumulation of pentachloroethane in each tissue during a continuous branchial (gill) exposure.
PROCEEDINGS OF THE THIRD ANNUAL MEETING OF THE CENTRAL SOCIETY FOR CLINICAL RESEARCH HELD IN CHICAGO, NOVEMBER 21, 1930
Journal: Journal of Clinical Investigation (1931)

Eddington in a report of focal necrosis of the liver as a result of ligation of the common duct and infection with B. aertrycke, noted that one of the controls with ligation of the common bile duct, happened to be well advanced in pregnancy.It died four days after the operation and although its liver showed well marked focal necrosis, careful cultural investigations were negative.We have produced focal necrosis of the liver by feeding meat to dogs and injecting tissue fibrinogen in the peripheral circulation.Lesions produced in this way showed a peripheral hemorrhage and necrosis, the lesion characteristic of eclampsia.Eddington's experiments have been repeated, using chiefly pregnant guinea pigs near term.Marked liver lesions have been produced, some showing hemor- rhage, but the majority pure necrosis.The lesions have been mostly central and mid zonal.Untoward Effects of Intravenous Sodium Chloride Solution in Severe Renal Insuffi- ciency.ByE.G. WAKEFIELD, M.D., andN.M. KEiTI, M.D., Rochester, Minn.Two cases of chronic glomerulonephritis with severe renal insufficiency showed an intolerance to the intravenous administration of sodium chloride.Both had a blood creatinin of 12 mgm.per cent on admission.In both, the prolonged intra- venous injection of ten per cent glucose solution containing one per cent sodium chloride resulted in anuria or oliguria.Subsequent administration of glucose solu- tion alone resulted in a satisfactory urinary excretion.These findings have both theoretical and practical significance.Experimental Edema.
Galen's Written Works
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Unit general managers in Scotland
Journal: BMJ (1986)

A police surgeon who is called out by the police in connection with an unexpected death in suspicious circumstances will receive £36 instead of £33-80.The fee for a statement to the police will go up from £13-50 to £14-40.The minimum fee paid to Home Office pathologists for night time calls has been increased from £46-20 to £50-50.Full details are available from regional offices.
THE RIDDLE OF MIGRAINE
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal