tbuckley/cabot-search huggingface dataset:
Presence, Introduction and Removal of Mutagenic Activity during the Preparation of Drinking Water in the Netherlands
Authors: H. J. Kool, C. F. van Kreijl, E. de Greef, H. J. van Kranen
Journal: Environmental Health Perspectives (1982)

A survey of the presence of mutagenic activity in drinking water of 18 cities in the Netherlands revealed that in drinking water of 13 cities mutagenic activity could be demonstrated. The activity was detected in the Ames test after concentrating the organic mutagens with a XAD-4/8 procedure. Dose-related responses were observed with concentrates corresponding to 0.5 to 3.0 liters of drinking water. A study of the changes in mutagenic activity during the preparation of drinking water in a few waterworks showed that breakpoint chlorination, transport chlorination and post chlorination increased the mutagenic activity, while ozonation only reduced the activity with metabolic activation. When adsorption on activated carbon powder was used, a certain reduction of mutagenic activity was observed. The use of activated carbon filters, however, removed the activity completely. The majority of organic mutagens present in drinking water concentrates were shown to be nonvolatile and relatively stable and probably consist of compounds with a molecular weight in the order of 200. These mutagens are not identical to the organics identified up till now in drinking water by standard gas chromatography/mass spectrometry analysis. Finally, a group of organic mutagens, which adsorbs only at pH 2-3 on XAD-4/8 (acid fraction), could be demonstrated in Ames-positive drinking waters.
Sudden catatonic stupor with disastrous outcome
Authors: Q. R. Regestein
Journal: JAMA (1977)

Catatonic stupor occurred in two psychiatric inpatients, predisposing them to staphylococcal pneumonia, venous thrombosis, and pulmonary embolism. Disastrous outcomes ensued. Catatonic stupor can lead to fatal complications, and aggressive medical and psychiatric therapy is indicated. (<i>JAMA</i>238:618-620, 1977)
Book Review Practical Radiation Therapy . By Ira I. Kaplan, B.S., M.D., Director, Division of Cancer, Department of Hospitals, New York City; Attending Radiation Therapist, Bellevue Hospital: with a special chapter on Applied X-Ray Physics by Carl B. Braestrup, B.Sc., P.E., Radiation Physicist, Division of Cancer, Department of Hospitals, Physicist to Mt. Sinai Hospital, New York City. 354 pages with 227 illustrations. Philadelphia and London: W. B. Saunders Company, 1931. Cloth, $6.00.
Journal: New England Journal of Medicine (1931)
Deaths
Journal: JAMA (1910)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TRUTH AND POETRY CONCERNING URIC ACID.
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The evaluation of liver resection for colorectal cancer liver metastases
Authors: M. Ogawa, K. Haruki, A. Horiuchi, H. Shiba, Y. Mitsuyama, M. Kusumoto, S. Eto, M. Ishiyama, T. Hasegawa, K. Yoshida, K. Yanaga
Journal: Annals of Oncology (2018)

Introduction: In colorectal cancer chemotherapy, FOLFOX from 2004.4.1, molecular targeted agents from 2009.9.1, has been covered by insurance reimbursement in Japan. In addition, our department expanded the surgical indications from 2004, and actively enforced liver resection. We retrospectively examined the treatment outcome of liver resection for colorectal cancer liver metastases (CRLM) to verify the efficacy of the method and strategy of the new treatment. Methods: In our department,132 cases of first liver resection were performed for CRLM from April 2004 to December 2015, and 123 cases traceable for data analysis. The group that underwent liver resection (first resect able cases) defined as group A, chemotherapy performed at the time of define diagnosis of metastasis and underwent conversion therapy of liver resection, as group B and compared the survival outcomes between the two groups. Unilateral metastasis group (group C) and bilateral metastasis group (group D) were compared in the same manner, also in comparison due to the presence or absence of post-operative chemotherapy. Results: ①5-year recurrence-free survival rate (5YRFSR) of liver resection of all 123 cases is 28.7%, the 5-year survival rate (5YSR) was 52.7%. In the multivariate analysis, in 5RFSR, extra hepatic lesions, metastatic cite, was an independent factor. In regard to 5YSR, N factor, post-operative chemotherapy was an independent factor. ② There was no significant difference in 5YRFSR (31.4%) of group A (n = 91) and in group B (n = 32) (p = 0.477), and no significant difference in 5YSR (57.3%) of group A (n = 86) and in group B (n = 37) (p = 0.063). ③ There was no significant difference in 5YSR of group C (n = 88) and in group D (n = 35) (p = 0.135). ④ 5YSR for the first time resect able cases (n = 70) in group C, was 65.2%, but no significant difference compared with the conversion cases (n = 18) was not observed (p = 0.057). ⑤ 5-year survival rate for the first resect able cases (n = 21) of the D group 34.0% and compared with the conversion cases (n = 14) was not significant difference (p = 0.64). ⑥ In comparison due to the post-operative chemotherapy in group C and group D, significant difference in 5YSR was not observed (p = 0.145, p = 0.140). Conclusion: 5YSR of 52.7% by liver resection was obtained and had a favorable outcome, and the conversion cases had an equal prognosis compared to the cases of first resection. Post-operative chemotherapy was a prognostic factor of colorectal cancer liver metastases.
Myxedema Coma
Authors: Stephen R. Newmark
Journal: JAMA (1974)

MYXEDEMA coma is the extreme clinical expression of hypothyroidism. It is characterized by coma, hypothermia, cardiovascular collapse, hypoventilation, and severe metabolic derangements, including low serum sodium, hypoglycemia, and lactic acidosis. Mild to moderate hypometabolism, lethargy, and sleepiness secondary to untreated hypothyroidism is<i>not</i>myxedema coma and should not be treated as such. Generally, myxedema coma requires several years of untreated hypothyroidism to develop, and usually, it occurs in elderly people who have been without medical care. Before treatment for myxedema coma is initiated, other medical conditions causing similar signs and symptoms should be ruled out. Prognosis is guarded (greater than 50% mortality), and success depends upon prompt institution of appropriate therapy.<sup>1-3</sup> <h3>Treatment</h3><h3>Administration of Thyroid Hormone.—</h3> The rational course of therapy is to deliver<i>thyroid</i>hormone to the patient. However, myxedematous patients are frequently extremely sensitive to the metabolic effects of thyroid hormones and may sustain cardiac damage. Nevertheless, it
Analysis of Repair and Mutagenesis of Chromium-Induced DNA Damage in Yeast, Mammalian Cells, and Transgenic Mice
Authors: Lei Cheng, Shaojun Liu, Kathleen Dixon
Journal: Environmental Health Perspectives (1998)

Chromium (Cr) is a widespread environmental contaminant and a known human carcinogen.We have used shuttle vector systems in yeast, mammalian cells, and transgenic mice to characterize the mutational specificity and premutational DNA damage induced by Cr(VI) and its reduction intermediates in order to elucidate the mechanism by which Cr induces mutations.In the yeast system, treatment of vector-containing cells with Cr(VI) results in a dose-dependent increase in mutations in the SUP4-o target gene of the vector; mutagenesis is enhanced in an apn-1 yeast mutant, deficient in the capacity to repair oxidative-type DNA damage.In vector-containing mammalian cells, treatment with Cr(V1) also results in a dose-dependent increase in mutations in the vector target gene supF The Cr-induced mutations in supF occurred mostly at G:C base pairs and were widely distributed across the gene, a pattern similar to those observed with ionizing radiation or hydrogen peroxide.These results support the hypothesis that Cr(IVI-induced oxidative- type DNA damage is responsible for Cr mutagenesis in the cell.Recently these studies were extended into the Big Blue transgenic mouse system in which Cr-induced mutagenesis was observed in the lung, the target organ for Cr carcinogenesis in humans.Analysis of the spectrum of these mutations will test whether Cr mutagenesis occurs by similar mechanisms in the intact animal as in cell culture systems and yeast.
Pseudotumor Cerebri
Authors: ALISON C. REID
Journal: Annals of Internal Medicine (1982)

Letters and Corrections1 December 1982Pseudotumor CerebriALISON C. REID, M.D., B.S.ALISON C. REID, M.D., B.S.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-97-6-931_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I write with regard to the review, "Pseudotumor Cerebri," by Ahlskog and O'Neill in the August issue (1). This is a cumbersome article, unselective in its content, which serves only to add to existing confusion about the syndrome. The authors have unfortunately omitted reference to a number of recent papers that have thrown light on the subject.A large number of causes of pseudotumor cerebri are cited and possible mechanisms discussed, with the authors concluding that decreased absorption of cerebrospinal fluid is the most likely explanation. The authors infer that pseudotumor cerebri is one condition with one...References1. AHLSKOGO'NEILL JB. Pseudotumor cerebri. Ann Intern Med. 1982;97:249-56. LinkGoogle Scholar2. REIDMATHESONTEASDALE AMG. Volume of the ventricles in benign intracranial hypertension. Lancet. 1980;2:7-8. CrossrefMedlineGoogle Scholar3. REIDTEASDALEMATHESONTEASDALE AGME. Serial ventricular volume measurements: further insights into the aetiology and pathogenesis of benign intracranial hypertension. J Neurol Neurosurg Psychiatry. 1981;44:636-40. CrossrefMedlineGoogle Scholar4. REIDTEASDALEMCCULLOCH AGJ. Steroid hormones and water permeability across the blood-brain barrier. J Cerebral Blood Flow Metab. 1981;1 (suppl):375-6. Google Scholar5. PRICEONABANJO DS. A dynamic pressure profile in the management of patients with glioma. In: BEKS JWF, BOSCH DA, BROCK M, eds. Intracranial Pressure. Berlin: Springer Verlag; 1976: 314-9. CrossrefGoogle Scholar6. REIDDRAPER AI. The pathogenesis of papilloedema and raised intracranial pressure in the Guillain-Barré syndrome. Br Med J. 1980;281:1393-4. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ALISON C. REID, M.D., B.S. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byResolution of Pseudotumor Cerebri following surgery for morbid obesity 1 December 1982Volume 97, Issue 6Page: 931-931KeywordsCerebrospinal fluid ePublished: 1 December 2008 Issue Published: 1 December 1982 PDF downloadLoading ...
Cardiac Apex Impulse: Clinical and Angiographic Correlations.
Authors: James S. Cole
Journal: Annals of Internal Medicine (1969)

s1 May 1969Cardiac Apex Impulse: Clinical and Angiographic Correlations.James S. Cole, M.D., Robert D. Conn, M.D., F.A.C.P.James S. Cole, M.D.Search for more papers by this author, Robert D. Conn, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-70-5-1075_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptStandard criteria have not been developed to describe the clinical characteristics of the cardiac apex impulse, and useful correlations between "abnormal" apex impulses and alterations in left ventricular mass and volume have not been established. In this study the apex impulse was evaluated at the bedside in 44 patients with valvular or congenital heart disease and compared with the left ventricular mass, and volume was determined by quantitative angiography. The wave form of the impulse was evaluated using a fiber-optic transducer and recorded on a Sanborn 500 electrocardiogram machine. The palpable characteristics of the impulse were described in terms of... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Seattle, Washington PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1969Volume 70, Issue 5Page: 1075-1075KeywordsAngiographyCongenital heart diseaseElectrocardiographyLongitudinal studies Issue Published: 1 May 1969 PDF DownloadLoading ...
Association of Posttraumatic Stress Disorder With Somatic Symptoms, Health Care Visits, and Absenteeism Among Iraq War Veterans
Authors: Charles Hoge
Journal: American Journal of Psychiatry (2007)

Objective: Studies of soldiers from prior wars conducted many years after combat have shown associations between combat-related posttraumatic stress disorder (PTSD) and physical health problems. The current Iraq war has posed a considerable PTSD risk, but the association with physical health has not been well studied. Method: The authors studied 2,863 soldiers using standardized self-administered screening instruments 1 year after their return from combat duty in Iraq. Results: Among all participants, 16.6% met screening criteria for PTSD. PTSD was significantly associated with lower ratings of general health, more sick call visits, more missed workdays, more physical symptoms, and high somatic symptom severity. These results remained significant after control for being wounded or injured. Conclusions: The high prevalence of PTSD and its strong association with physical health problems among Iraq war veterans have important implications for delivery of medical services. The medical burden of PTSD includes physical health problems; combat veterans with serious somatic concerns should be evaluated for PTSD.
Medical Microscopy. A Guide to the use of the Microscope in Medical Practice.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Participants In Continuing Education Programs
Authors: Thomas Pettit, William Spencer, David Worthen, Joseph Yarbrough, Diego San, Richard Cavanagh, Joel Einaugler, Stephen Waltman, Louis Section, Ronald Burde, Eleanor Louis, Louis St, L David, George Weinstein, Tex Antonio, Intraocular Inflammation, Ocular Tumors, Ronald Smith, Alan Angeles, Conrad Friedman, Joe Southfield, Denis O'day, Donald Hall, Howard Leibowitz, Richard Smith, Fred Albany, Deborah Langston, Charles Phelps, Otto Elser, H Dunbar Hoskins, Francisco San, L Robert, Francisco Stamper, Mansour Armaly, Arthur Grove, J Blaydes, Frederick Jakobiec, Charles Leone, Fla Older, Bartley Consultant, Richard Kielar, James Clower, J Rowsey, Robert Waller, Joseph Walsh, Richard Einaugler
Journal: Ophthalmology (1979)
Diseases of the Eye.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Catheter-associated bacteriuria. Failure to reduce attack rates using periodic instillations of a disinfectant into urinary drainage systems
Authors: R. L. Thompson
Journal: JAMA (1984)

We assessed the efficacy of periodic instillations of hydrogen peroxide into urinary drainage systems in the prevention of catheter-associated bacteriuria in a prospective and randomized clinical study of 668 patients with indwelling urethral catheters. Bacteriuria was documented in 68 (10%) of the 668 patients after a mean duration of four days of catheterization. There was no difference between the hydrogen peroxide group and the control group in the mean duration of catheterization before the onset of bacteriuria, in the attack rate for bacteriuria, or in the spectrum of etiologic agents recovered. Bag contamination with the same organism responsible for bacteriuria preceded infection in only five (7%) of the 68 patients, three patients using hydrogen peroxide and two in the control group. We conclude that infections arising intraluminally from contamination of the drainage bag are uncommon among catheterized patients and that the periodic instillation of disinfectants into closed sterile drainage systems is not effective in reducing the incidence of catheter-associated bacteriuria. (<i>JAMA</i>1984;251:747-751)
A Course of Lectures on Urine, Urinary Deposits, and Calculi
Authors: L. Beale
Journal: BMJ (1860)

Uric Acid resembling Albumen; Cases.Apparent Absence of Albumen in Urine which contains a large Quantity; Cases.Cause of the Precipitation of Albumen by Heat being prevented by a Trace of Nitric Acid.Other Tests for Albumen.On Estimating the Quantity of Albumen.Peculiar Substance in Urine allied to Albumen.Of the Importance of Albumen in Urine in a Clinical point of view.Dropsy in Disease of the Kidney.BILE.Tests.Nitric Acid.Heller's Test.Pettenkofer's Test.Yellow Colour of the Cells, etc., in the Urinary Deposit.SUGAR.General Characters of the Urine in Diabetes.Diabetic Sugar.Tests for Diabetic Sugar; Moore's Test; Tronnmer's Test; Barreswill's and other Solutions.On Testing for Sugar when only Traces are present.Circum- stances interfering with the Action of Trommer's Test.Of the Yeast Test.Maumenh's or the Perchloride of Tin Test.Bismuth Test.Of Estimating the Quantity of Sugar; volumetrically; by Fermentation; by Dr. Garrod's Method; by the Polarising Saccharimeter.Circumstances under which Sugar is excreted in the Urine.Analyses of Urine in Diabetes.OTHER SOLUBLE SUBSTANCES WHICH ARE NOT PRESENT IN HEALTH.LEUCINE.TYROSINE.INOSITE.ACETONE.CYSTINE.[Continued from page 876.]Of Estimating the Quantity of Sugar.The quantity of sugar is easily determined, though not with absolute accuracy, by fermentation.The quantity of carbonic acid formed may be measured, weighed directly, or its weight may be determined by ascertaining the loss of weight the urine has sustained from
JAMA Reference Directories
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal