tbuckley/cabot-search huggingface dataset:
STATE MEDICINE.
Journal: JAMA (1884)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Short Takes
Authors: John W. Burnside
Journal: Annals of Internal Medicine (2001)

On Being a Doctor6 November 2001Short TakesJohn W. Burnside, MDJohn W. Burnside, MDUniversity of Texas Southwestern Medical School; Dallas, TX 75235Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-135-9-200111060-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Usual and CustomaryI have become a usual and customary physician. I didn't plan on it, and it happened without my paying much attention. Since I get paid the usual and customary fee, I must be a usual and customary doctor. Strange—I thought I was better than that. I thought that because of my experience and apparent success, at least as determined by the number of patients who want to see me but whom I must refuse, that I was better than average. I guess not. I thought, too, that when I referred my patients to surgeons that I was ... Author, Article, and Disclosure InformationAffiliations: University of Texas Southwestern Medical School; Dallas, TX 75235Corresponding Author: John W. Burnside, MD, 5323 Harry Hines Boulevard, Dallas, TX 75235; e-mail, [email protected]swmed.edu. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 6 November 2001Volume 135, Issue 9Page: 837-838KeywordsAIDSDrug discoveryDrugsHearingMorphineMouthOintmentsSmellSurgeonsSystems biology ePublished: 6 November 2001 Issue Published: 6 November 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Front &amp; Back Matter
Authors: Dina Popovic, Maria Reinares, Jan Scott, Alessandra Nivoli, Andrea Murru, Isabella Pacchiarotti, Eduard Vieta, Francesc Colom, Christian Gold, Karin Mössler, Denise Grocke, Tor Olav Heldal, Lars Tjemsland, Trond Aarre, Leif Edvard Aarø, Hans Rittmannsberger, Brynjulf Stige, Jörg Assmus, Randi Rolvsjord, Silvia Schneider, Tina In-Albon, Birgit Nuendel, Jürgen Margraf, Beate Muschalla, Johannes Glatz, Michael Linden, Kenji Hashimoto, Keiko Okawada, Junko Tone, Akira Machizawa, Aya Tano, Michiko Nakazato, Masaomi Iyo, Andreas Baranyi, Andreas Meinitzer, Alexandra Stepan, Csilla Putz-Bankuti, Robert J. Breitenecker, Rudolf Stauber, Hans-Peter Kapfhammer, Hans-Bernd Rothenhäusler, Hiske van Ravesteijn, Peter Lucassen, Hans Bor, Chris van Weel, Anne Speckens, Giovanni A. Fava, Chiara Rafanelli, Laura Sirri, Silvana Grandi, Tsuyoshi Sasaki, Emilie Olié, Philippe Courtet, Vanessa Poulain, Sébastien Guillaume, Karen Ritchie, Sylvaine Artero, Eric L. Garland, Matthew O. Howard, Nikos G. Christodoulou, George N. Christodoulou, Satz Mengensatzproduktion, Druck Reinhardt Druck Basel, Druck Reinhardt Druck Basel
Journal: Psychotherapy and Psychosomatics (2013)
Correction.
Authors: Edward Playter
Journal: JAMA (1894)

Ottawa, Can., June 6, 1894. <h3>To the Editor:</h3> It has but just come to my notice that there are several unpleasant typographical errors in my paper on Physiotherapy in theJournalof May 26, and which I corrected in revised proof. I presume you did not receive proof before going to press. Besides errors in the Greek lettering, in spelling two or three proper names and in punctuation, especially in breaking with a period and a capital the last sentence (a long one, to be sure) in the first paragraph, there are errors in the last paragraph which would lead a hasty reader to think it was I who had started the "water cure." Instead of, "I placed myself under the care of a Mr. Brown, who had during the time of Priessnitz a popularity which extended to the uttermost parts of the earth; and started a.. 'water cure,'" kindly
Dynamin2- and endothelial nitric oxide synthase–regulated invasion of bladder epithelial cells by uropathogenic<i>Escherichia coli</i>
Authors: Zhimin Wang, Ceba Humphrey, Nicole Frilot, Gaofeng Wang, Zhongzhen Nie, Nader H. Moniri, Yehia Daaka
Journal: The Journal of Experimental Medicine (2011)
The Cover
Authors: William H. Crosby
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Adjuvant chemotherapy in colorectal cancer: mournful, hopeful perpetual motion machine heads to dim light at end of tunnel
Authors: Lawrence H. Clouse
Journal: JAMA (1989)

<h3>To the Editor.—</h3> Buyse and colleagues<sup>1</sup>thoroughly reviewed the extensive literature on randomized, controlled trials of adjuvant chemotherapy for colorectal carcinoma. Coincidentally, this month the Southwest Oncology Group reported their fully mature adjuvant colorectal study,<sup>2</sup>seven years after the last patient accrual, and concluded that semustine and fluorouracil did not improve survival in treated patients compared with concurrent controls. It should be abundantly clear that adjuvant treatment for colorectal carcinoma with currently available drugs is a failure. It is not merely that we have yet to show a potential benefit; we have actually repeatedly and consistently<i>failed</i>to show a benefit sufficient to be meaningful to an individual patient. Indeed, few treatments in modern oncology have such a wealth of data documenting the futility of the approach. It is true that some trials have shown a tiny benefit for the adjuvant approach; however, even when a trial accrues
A fork in the road of cell differentiation in the kidney tubule
Authors: Q. Al-Awqati
Journal: Journal of Clinical Investigation (2004)

The collecting ducts of the kidney are composed of intercalated cells (responsible for acid/base transport), principal cells (mediating salt and water absorption), and inner medullary cells, which mediate all three types of transport. Forkhead box (Fox) genes are a large family of transcription factors that are important in cell-type specification during organogenesis. In this issue, Blomqvist et al. find that mice lacking Foxi1 have no intercalated cells in the kidney . The collecting ducts of the null mice contained primitive cells that expressed both intercalated cell and principal cell proteins, yet the acid/base transport function of the kidney was disrupted and the mice exhibited distal renal tubular acidosis. These findings suggest that Foxi1 plays a critical role in determining cell identity during collecting duct development.
Military Medicine
Authors: L. Harrison Hassell
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pulsed methylprednisolone.
Authors: A Oto, T Sozen, S Boyacioglu
Journal: Annals of the Rheumatic Diseases (1981)

Dapsone in rheumatoid arthritisSir, We read with interest the paper by Swinson et al.1 on a double-blind trial of dapsone against placebo in the treatment of rheumatoid arthritis.We recently undertook a similar double-blind study using dapsone in an identical dose regimen to that already described (50 mg daily for one week and thereafter 100 mg daily) in 14 white patients with seropositive rheumatoid arthritis and comparing it against placebo (vitamin C) in 14 matched controls.While we observed a similar trend towards improvement in both clinical and serological parameters in the dapsone-treated group, the incidence of anaemia secondary to haemolysis in our dapsone-treated patients was greater than that previously recorded.2Four of the 14 patients receiving dapsone had falls in haemoglobin of greater than 3 g/dl, and a further 3 patients had falls of between 1 and 3 g/dl.In all cases the fall in haemoglobin occurred within 6 weeks of commencing the therapy.Only one patient in the placebo group had a fall in haemoglobin of greater than 1 g/dl.It has been demonstrated that the haemolytic activity of dapsone is dependent upon its being metabolised to an acetylated form.3Therefore, in an attempt to elucidate further why some of our patients should develop severe haemolysis, we assessed the acetylator status (using isoniazid) in 13 of the patients receiving dapsone, 3 of whom had had falls in haemoglobin of greater than 3 g/dl and 3 of whom had had falls between 1 and 3 g/dl.The acetylator studies were performed in the University Department of Pharmacology, Newcastle upon Tyne.Eight of the patients were fast acetylators, but we failed to observe any association between the acetylator status and the severity of haemolysis.This pilot study, therefore, while supporting the view that dapsone is an effective therapy in rheumatoid arthritis, also reveals a higher incidence of significant haemolysis than has previously been described.It does not appear that the identification of the acetylator status of rheumatoid patients is of any benefit in identifying patients who may develop significant haemolysis.
Effect of sodium phenobarbital on bilirubin metabolism in an infant with congenital, nonhemolytic, unconjugated hyperbilirubinemia, and kernicterus
Journal: Journal of Clinical Investigation (1969)

Nicotinic acid minus controls group, for + 12.3 read + 2.3 p. 1803, left column, paragraph 1, line 9, for 10)-(0.25 x 0.40 x 0.3 x 0.3 x 60 x 4.5 ) %:read 10)-(0.25 x 0.40 x 0.3 x 3 x 60 x 4.5)#
Kawasaki Syndrome
Authors: Penelope G. Shackelford, Arnold W. Strauss
Journal: New England Journal of Medicine (1991)

Kawasaki syndrome, first identified by Tomisaku Kawasaki, is a multisystem disease of young children that is also known as the mucocutaneous lymph node syndrome.1 The most serious complication is vasculitis of the coronary arteries. Kawasaki syndrome occurs worldwide and is a reportable disease in the United States, where the annual incidence is 4.5 to 8.5 cases per 100,000 children less than five years of age. When outbreaks occur, the incidence may rise to more than 150 per 100,000 children in a particular community. No evidence for a point source or for person-to-person transmission has ever been documented, however.The cause . . .
THE PATHOLOGY AND ETIOLOGY OF THE DISEASES OF THE ACCESSORY CAVITIES OF THE NOSE.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Impact of Benzene Metabolites on Differentiation of Bone Marrow Progenitor Cells
Authors: Richard D. Irons, Wayne S. Stillman
Journal: Environmental Health Perspectives (1996)

Interleukin-3 (IL-3) and granulocyte/macrophage-colony-stimulating factor (GM-CSF) are responsible for maintaining survival and stimulating growth of early dormant hematopoietic progenitor cells (HPC).These cytokines exhibit extensive overlap, with GM-CSF supporting growth and differentiation of myeloid HPC.A characteristic shared by a diverse group of leukemogens is the ability to act synergistically with GM-CSF to increase clonogenic response.Previous studies have revealed that pretreatment of murine HPC with hydroquinone (HO) but not phenol, catechol, or trans-trans-muconaldehyde results in a selective enhancement of GM-CSF but not IL-3-mediated clonogenic response.Pretreatment of murine bone marrow cells with these agents or their metabolites in vitro results in increased numbers of HPC dividing and forming colonies in response to GM-CSF but not IL-3.The present studies explored the molecular mechanisms associated with altered cytokine response in early HPC in murine bone marrow and extended our initial observations in murine bone marrow to human bone marrow cells.HQ pretreatment of murine HPC did not induce either an up-or a down-regulation of GM-CSF receptors or any change in receptor affinity.CD34+ cells, which represent between 1 and 5% of human bone marrow, contain virtually all clonogenic stem and HPC.Pretreatment of CD34+ cells (-95% purity) with HO also results in enhanced clonogenic response with GM-CSF but not IL-3.These findings suggest that an early step in chemical leukemogenesis may involve transient alterations in the regulation of cytokine response to GM-CSF.
From the NIH: A hormonelike epidermal product stimulates immune reactions
Journal: JAMA (1983)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medical Organization
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An Address Delivered at the Opening of the Section of Medicine
Authors: W. H. Broadbent
Journal: BMJ (1886)

THE .BRrTISR MEDIOAL OURAL.311 we cannot be too eager to avail ourselves of.In fact, the general practitioner is the living embodiment of that principle I wish so strongly to establish-the necessary and close connection between medicine and surgery, a principle nobly illustrated by many of our great provincial surgeons.Our practice comprises both medicine and surgery; our medical experience out of doors is brought to bear upon our patients in the surgical wards of our hospital.Chloroform has taken away from the value of the rapid aid brilliant operation.'He is the most successful surgeon who is also the good physician.Surgery shonld get more dependent on medicine for its help.Operative sur- gery, fiom the nature of thing, must have a limit, and surely that limit must be nearly reacher.Let the medical aspect of surgery, then, command .more of your interest and attention.I wish I were a better exponent of its principles, a better example of its practice.
Endoscopy and biliary
Authors: P Anker, X Chen, J Lyautey, C Lederrey, M Stroun, A Ballinger, S Carneby, Ema Alstead, M Hull, J Brough
Journal: Gut (1996)

Malignant cells have previously been isolated from the faeces, urine, sputum and pancreatic juice of cancer pauients.DNA has also been isolated from blood plasma using laborious and time consuming procedures.This plasma DNA can then be charactersed using complex polymerase chain reaction (PCR) assays with subsequent product sequencing.We have developed a simple technique for extracting DNA from blood plasma and have optimised a sensitive PCR assay to detect codoon 12 K-ras mutations in plasma DNA.DNA was extracted from plasma using a two-stage technique.After initial centifugation of blood, plasma was subjected to high speed microcentrifugation using a commercial kit with in-house modifications.A sensitive PCR assay using sequence specific primers (PASA) was developed to detect K-ras mutations.PASA- PCR results were confirmed by restriction fiagment length polymorphism (RFLP) PCR with product sequencing.The technique developed to extract plasma DNA proved robust and reproducible.Usable quantities of DNA were extacted from 3 ml of plasma obtained from each of 14 pancreatic cancer patients.The optimised PASA-PCR assay was capable of detecting one mutant K- ras gene (TGT, GTT, GCT or GAT) in 10,000 wild-type (GOT) copies.Using the DNA extraction technique and PASA-PCR assay, K-ras mutations were detected in the plasma of pancreatic cancer patients.In cases where paired plasma and tumour samples were available, mutations were identical in both plasma and tumour DNA.We conclude that simple procedures may be used to extract DNA from the plasma of pancreatic cancer patients.In addition, the PASA- PCR assay may prove useful for detecting minute quantities of mutant K-ras genes within a large excess of wild-type copies.
LEAGUE OF NATIONS INVESTIGATION AND REPORT ON TREATMENT OF EARLY SYPHILIS
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal